PMID- 42958216 OWN - NLM STAT- MEDLINE DCOM- 20261030 LR - 20261030 IS - 1472-6874 (Electronic) IS - 1472-6874 (Linking) VI - 26 IP - 1 DP - 2026 Jul 28 TI - Physical activity and health-related quality of life in women with polycystic ovary syndrome attending fertility clinics in Sri Lanka: a cross-sectional study. LID - 567 [pii] LID - 10.1186/s12905-026-04742-2 [doi] AB - BACKGROUND: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder that substantially impairs health-related quality of life (HRQoL). Regular physical activity is a recommended first-line intervention, but the relationship between activity and HRQoL is understudied in South Asian women, particularly in those attending fertility clinics who carry the additional psychological burden of infertility. This study aimed to examine the association between physical activity levels and PCOS-specific HRQoL in women with PCOS attending fertility clinics in Colombo, Sri Lanka. METHODS: An analytical cross-sectional study was conducted at the fertility clinics of two tertiary care hospitals in Colombo, Sri Lanka: De Soysa Hospital for Women and Children and Castle Street Hospital for Women between 13 October and 7 November 2025. Eighty-five women aged 18-45 years with a clinician-confirmed diagnosis of PCOS were recruited by convenience sampling. Physical activity was assessed using the International Physical Activity Questionnaire - Short Form (IPAQ-SF), validated to the Sri Lankan setting, and expressed as MET-minutes per week. HRQoL was measured using the Polycystic Ovary Syndrome Questionnaire (PCOSQ), validated in the Sri Lankan setting, which yields a total score and five domain scores (emotions, body hair, weight, infertility, menstrual problems) on a 1-7 scale, with higher scores indicating better HRQoL. PCOS phenotype was classified according to the Rotterdam criteria. Continuous variables were summarized using medians and interquartile ranges, and Spearman's rank correlation (r(s)) was used to examine the association between physical activity and HRQoL. RESULTS: The mean (SD) age was 28.0 (4.9) years, and the median (IQR) age was 28 (24-30) years; the median body mass index was 30.2 (28.0-32.4) kg/m(2). The majority of participants (60.0%, n = 51) were classified as having low physical activity, with a median total activity score of 1017.0 (569.5-2459.3) MET-minutes/week. The median overall PCOSQ score was 3.07 (2.37-3.64), indicating moderate HRQoL impairment; the lowest-scoring domain was body hair and appearance (median 2.20), and the highest was infertility-related worries (median 3.50). Physical activity showed a statistically significant moderate positive correlation with overall HRQoL (r(s) = 0.465, p < 0.001). Domain-specific analyses revealed significant moderate positive correlations with emotional well-being (r(s) = 0.493, p < 0.001), weight (r(s) = 0.470, p < 0.001) and infertility (r(s) = 0.464, p < 0.001) domains, while body hair (r(s) = 0.210, p = 0.054) and menstrual symptoms (r(s) = - 0.027, p = 0.805) were not significantly associated. Phenotype-stratified analyses showed significant associations in Phenotype A (r(s) = 0.384, p = 0.004) and Phenotype B (r(s) = 0.490, p = 0.015); Phenotypes C (n = 2) and D (n = 4) were underpowered. CONCLUSIONS: In this cross-sectional sample, higher physical activity levels were associated with better overall PCOS-specific quality of life among women attending fertility clinics in Colombo, with the strongest domain-specific associations observed for emotional well-being, weight, and infertility-related concerns. Because the design was cross-sectional, causality cannot be inferred. Nonetheless, given that sixty per cent of participants did not meet recommended activity levels, these findings support routinely assessing physical activity in fertility clinic care and suggest that physical activity may be a useful target for future longitudinal and interventional studies of HRQoL in women with PCOS in Sri Lanka. CI - (c) 2026. The Author(s). FAU - Lakshan, G A R AU - Lakshan GAR AD - Department of Allied Health Sciences, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. FAU - Rishard, Mohamed AU - Rishard M AD - Department of Obstetrics and Gynecology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. mrishard@obg.cmb.ac.lk. LA - eng PT - Journal Article DEP - 20260728 PL - England TA - BMC Womens Health JT - BMC women's health JID - 101088690 SB - IM MH - Humans MH - Female MH - *Polycystic Ovary Syndrome/psychology MH - *Quality of Life/psychology MH - Sri Lanka MH - Cross-Sectional Studies MH - Adult MH - *Exercise/psychology MH - Adolescent MH - Young Adult MH - Surveys and Questionnaires MH - Middle Aged MH - Infertility, Female/psychology OAB - Polycystic ovary syndrome (PCOS) is a common hormonal condition in women of reproductive age that can cause irregular periods, difficulty becoming pregnant, weight gain, and unwanted hair growth, and it often affects women's day-to-day well-being. We asked eighty-five women with PCOS who were attending fertility clinics at two hospitals in Colombo, Sri Lanka, how physically active they were and how the condition was affecting their quality of life. 60% of the women were not doing enough physical activity to meet international recommendations, and most reported moderately reduced quality of life, with concerns about body hair and appearance and weight affecting them the most. Women who were more physically active reported better overall quality of life, better emotional well-being, fewer weight-related concerns, and less infertility-related distress. These findings suggest that asking women with PCOS about physical activity and helping them to be more active could be a simple and low-cost way for fertility clinics in Sri Lanka to improve patients' wellbeing alongside the medical treatment they are already receiving. OABL- eng OTO - NOTNLM OT - Fertility clinic OT - IPAQ-SF OT - PCOSQ OT - Physical activity OT - Polycystic ovary syndrome OT - Polyendocrine metabolic ovarian syndrome OT - Quality of life OT - South Asia OT - Sri Lanka COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Ethics Review Committee of the Faculty of Medicine, University of Colombo (ERC/2025/UCFM/P/2021/575). Institutional permission was obtained from the Directors of De Soysa Hospital for Women and Children and Castle Street Hospital for Women, Colombo. Written informed consent was obtained from all participants prior to enrolment. All methods were carried out in accordance with relevant guidelines and regulations, including the principles of the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/30 05:30 MHDA- 2026/10/30 05:31 CRDT- 2026/10/30 00:54 PHST- 2026/10/30 05:31 [medline] PHST- 2026/10/30 05:30 [pubmed] PHST- 2026/04/21 00:00 [received] PHST- 2026/07/24 00:00 [accepted] PHST- 2026/10/30 00:54 [entrez] AID - 10.1186/s12905-026-04742-2 [pii] AID - 10.1186/s12905-026-04742-2 [doi] PST - epublish SO - BMC Womens Health. 2026 Jul 28;26(1):567. doi: 10.1186/s12905-026-04742-2. PMID- 42956672 OWN - NLM STAT- Publisher LR - 20261029 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 229 DP - 2026 Oct 29 TI - Australian infants' food avoidance trajectory groups across the first year of life and associations with food fussiness and vegetable intake at 12 months. PG - 108804 LID - S0195-6663(26)00366-1 [pii] LID - 10.1016/j.appet.2026.108804 [doi] AB - Food avoidant eating behaviours in children are negatively associated with vegetable intake and diet quality. However, little is known about trajectories of food avoidance during infancy. This study examined food avoidant trajectory groups in the first year of life and their associations with fussiness and vegetable intake. Australian parents of infants aged 2 years), bottle-feeding, and inadequate oral hygiene practices (infrequent or unsupervised brushing and use of non-fluoridated toothpaste) were identified as key behavioral indicators significantly associated with increased S-ECC (P < 0.05). Furthermore, lower nutritional status and higher defs indices were strongly associated with poorer OHRQoL scores (P < 0.001). CONCLUSIONS: S-ECC and poor nutrition were prevalent among 4-5-year-olds, strongly associated with dietary habits, oral hygiene practices, and maternal education, while both conditions correlated with lower oral health-related quality of life. Importantly, higher ECC and poor nutrition were interrelated, highlighting the potential utility of integrated oral health and nutritional interventions in clinical pediatric settings. CI - (c) 2026. The Author(s). FAU - Nadeeshani, Harshani AU - Nadeeshani H AD - Nutritional Biochemistry Research Program, National Institute of Fundamental Studies, Kandy, Sri Lanka. AD - Department of Community Dental Health, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka. FAU - Narada, Malinda AU - Narada M AD - Department of Community Dental Health, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka. FAU - Gunawardena, Sadhisha AU - Gunawardena S AD - Nutritional Biochemistry Research Program, National Institute of Fundamental Studies, Kandy, Sri Lanka. FAU - De Alwis, Sudam AU - De Alwis S AD - Nutritional Biochemistry Research Program, National Institute of Fundamental Studies, Kandy, Sri Lanka. FAU - Dias, Chathumini AU - Dias C AD - Nutritional Biochemistry Research Program, National Institute of Fundamental Studies, Kandy, Sri Lanka. FAU - Kudagammana, Sanath Thushara AU - Kudagammana ST AD - Department of Paediatrics, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka. FAU - Herath, Chandra AU - Herath C AD - Department of Community Dental Health, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka. FAU - Jayasinghe, Ruwan AU - Jayasinghe R AD - Department of Oral Medicine and Periodontology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka. FAU - Liyanage, Ruvini AU - Liyanage R AD - Nutritional Biochemistry Research Program, National Institute of Fundamental Studies, Kandy, Sri Lanka. ruvini.li@nifs.ac.lk. LA - eng PT - Journal Article DEP - 20260723 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 SB - IM MH - Humans MH - Child, Preschool MH - Cross-Sectional Studies MH - *Quality of Life MH - Female MH - Male MH - *Dental Caries/epidemiology MH - *Oral Health/statistics & numerical data MH - *Nutritional Status MH - Sri Lanka/epidemiology MH - Oral Hygiene MH - Diet PMC - PMC13715219 OTO - NOTNLM OT - BMI OT - Defs OT - Deft OT - Early childhood caries OT - Oral health-related quality of life COIS- Declarations. Ethics approval and consent to participate: The ethical clearance certificate (ERC/FDS/UOP/I/2021/45) was obtained from the Ethical Review Committee, Faculty of Dental Sciences, University of Peradeniya, on 12th October 2021. According to that, Information regarding the research was conveyed to parents or guardians by a typed information sheet in a manner and a language suitable to the individual's level of understanding. The participants were given adequate opportunity to ask questions, and they were answered honestly and completely. Parents or guardians were made aware that they were free to withdraw their consent at any time without trepidation of consequences. Finally, the consent was obtained as a signature on a consent form that explicitly stated what was being consented to. Participants were not subjected to coercion, inducement, undue influence, or deception at any cost. Consent for publication: Parents or guardians were informed that these data would be published in journal articles, and consent was obtained as a signature on a consent form. Competing interests: The authors declare no competing interests. EDAT- 2026/10/28 05:28 MHDA- 2026/10/28 05:29 PMCR- 2026/07/23 CRDT- 2026/10/28 00:48 PHST- 2026/03/05 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/10/28 05:29 [medline] PHST- 2026/10/28 05:28 [pubmed] PHST- 2026/10/28 00:48 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - 10.1186/s41043-026-01407-6 [pii] AID - 1407 [pii] AID - 10.1186/s41043-026-01407-6 [doi] PST - epublish SO - J Health Popul Nutr. 2026 Jul 23;45(1):238. doi: 10.1186/s41043-026-01407-6. PMID- 42947253 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261028 LR - 20261029 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 14 IP - 1 DP - 2026 Oct 27 TI - Cross-group and longitudinal measurement invariance of the Child Eating Behavior Questionnaire-24G in middle childhood. LID - 10.1186/s40337-026-01806-4 [doi] LID - 252 AB - BACKGROUND: Childhood eating behaviors are most commonly assessed using parent-report questionnaires. To validly compare means across different groups or over time, equivalent item functioning is an important prerequisite. This study investigates the measurement invariance of a short German version of the Child Eating Behavior Questionnaire, the CEBQ-24G, across child sex, age, weight status, family socio-economic status, and parental weight status, as well as across three measurement occasions spanning three years in middle childhood. METHODS: Analyses were conducted using a large community sample (N = 1,657) recruited from primary schools in Brandenburg, Germany. Measurement invariance was tested and latent group means were compared using Multigroup Confirmatory Factor Analysis (CFA). RESULTS: The CEBQ-24G is measurement invariant on the residual level across all groups and measurement occasions, i.e., assessed differences in eating behaviors between these groups and measurement occasions are derived from actual differences in latent constructs and not a result of measurement bias-thus allowing valid comparisons of latent means across child sex, age, weight status, parental weight status, and family socio-economic status. We found significant differences in all group comparisons (except between age groups), although the eating behavior scales in which the differences in mean scores occurred varied depending on which groups were compared. CONCLUSIONS: Our findings suggest that the CEBQ-24G has good psychometric properties in all groups and is suitable for research into eating behaviors in middle childhood in diverse populations. CI - (c) 2026. The Author(s). FAU - Ruden, Joyce C AU - Ruden JC AUID- ORCID: 0009-0009-2462-8031 AD - Department of Psychology, Counseling Psychology, University of Potsdam, Potsdam, Germany. FAU - Warschburger, Petra AU - Warschburger P AUID- ORCID: 0000-0001-7979-7451 AD - Department of Psychology, Counseling Psychology, University of Potsdam, Potsdam, Germany. petra.warschburger@uni-potsdam.de. LA - eng PT - Journal Article DEP - 20261027 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC13711984 OAB - The 24-item German adaptation of the Child Eating Behavior Questionnaire (CEBQ-24G) is a tool to assess a child's eating behaviors via parent report. This study examined whether the questionnaire is understood in the same way across different groups and multiple measurements. Such measurement equivalence is required in order to make valid comparisons between eating behaviors across groups and over time. Using a sample of 1,657 children from primary schools in Brandenburg, Germany, we confirmed the questionnaire's measurement equivalence across child sex, age, weight status, family socio-economic status, and parental weight status, as well as across time in middle childhood. This enabled us to compare eating behaviors across these groups. We found differences in eating behaviors based on children's sex, weight status group, their parent's weight status group, and their family's socio-economic status, but not age. Overall, this study demonstrates that the CEBQ-24 validly assesses children's eating behavior in diverse samples and over time. OABL- eng OTO - NOTNLM OT - Child Eating Behavior Questionnaire OT - Childhood OT - Eating behavior OT - Group differences OT - Measurement invariance OT - Multigroup CFA OT - Parent report COIS- Declarations. Ethics approval and consent to participate: Approval was obtained from the ethics committee of the University of Potsdam, Germany (reference numbers 28-33/2011, 3-10/2012, 21/2012, 32/2014, 18/2020, 10/2022, and 37/2022). The procedures used in this study adhere to the tenets of the Declaration of Helsinki. Informed consent was obtained from each participant. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/28 05:28 MHDA- 2026/10/28 05:29 PMCR- 2026/10/27 CRDT- 2026/10/28 00:47 PHST- 2026/06/11 00:00 [received] PHST- 2026/10/18 00:00 [accepted] PHST- 2026/10/28 05:29 [medline] PHST- 2026/10/28 05:28 [pubmed] PHST- 2026/10/28 00:47 [entrez] PHST- 2026/10/27 00:00 [pmc-release] AID - 10.1186/s40337-026-01806-4 [pii] AID - 1806 [pii] AID - 10.1186/s40337-026-01806-4 [doi] PST - epublish SO - J Eat Disord. 2026 Oct 27;14(1):252. doi: 10.1186/s40337-026-01806-4. PMID- 42947061 OWN - NLM STAT- MEDLINE DCOM- 20261028 LR - 20261029 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 31 TI - Effects of school-based nutrition education on self-efficacy, attitudes, food behaviors, and health in children. LID - 10.1186/s12887-026-07412-2 [doi] LID - 1075 AB - BACKGROUND AND AIM: School-based nutrition education programs are commonly used to promote healthy eating behaviors among children; however, their effectiveness may vary according to developmental stage. The present study aimed to evaluate the effects of a school-based nutrition education program on children's dietary self-efficacy (CDSS), dietary attitudes (DAS), food behaviors (FBS), and children self-rated health scale (CSHC). MATERIALS AND METHODS: This study employed a pre-post nutrition intervention design and including 1418 primary and secondary school students from different grade levels. CDSS, DAS, FBS, and CSHC were assessed before and after the nutrition education using validated self-report scales. Changes following the intervention were statistically examined and differences according to grade level and gender were analyzed. RESULTS: Following the nutrition education program, a significant improvement was observed in child nutrition self-efficacy. In contrast, no significant overall changes were found in dietary attitudes, food behaviors, or self-rated health perception. Dietary attitudes and food behaviors differed significantly by grade level both before and after the intervention, with older children's dietary self-efficacy and food behaviors were more evident in certain lower grade levels. No significant differences were observed between girls and boys with respect to dietary attitudes or food behaviors. CONCLUSIONS: The findings suggest that while school-based nutrition education can enhance dietary self-efficacy, short-term educational interventions alone may be insufficient to produce measurable changes in children's eating behaviors. Developmentally tailored, multi-component interventions that incorporate family involvement and environmental factors may be necessary to support sustained improvements in dietary behaviors, particularly among older school-age children. CI - (c) 2026. The Author(s). FAU - Terzi, Merve AU - Terzi M AUID- ORCID: 0000-0003-3397-9692 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Istanbul Yeni Yuzyil University, Istanbul, Turkey. merve.terzi@yeniyuzyil.edu.tr. FAU - Ergan, Kubra AU - Ergan K AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Istanbul Yeni Yuzyil University, Istanbul, Turkey. AD - Department of Nutrition and Dietetics, Istinye University, Graduate School, Istanbul, Turkiye. FAU - Demirkesen-Bicak, Hilal AU - Demirkesen-Bicak H AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Istanbul Yeni Yuzyil University, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20260731 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Male MH - Female MH - *Self Efficacy MH - Child MH - *Feeding Behavior/psychology MH - *Health Education/methods MH - *School Health Services MH - *Health Knowledge, Attitudes, Practice PMC - PMC13715218 OTO - NOTNLM OT - Dietary attitudes OT - Dietary self-efficacy OT - Eating behaviors in children OT - Health-related quality of life OT - School-based nutrition intervention COIS- Declarations. Ethics approval and consent to participate: Ethical approval for this study was obtained from the Istanbul Yeni Yuzyil University Ethics Committee (Approval Number: 2025/03-1511). All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee and with the Declaration of Helsinki and its later amendments. Written informed consent was obtained from the parents/legal guardians of all participants prior to participation in the study. Competing interests: The authors declare no competing interests. EDAT- 2026/10/28 05:28 MHDA- 2026/10/28 05:29 PMCR- 2026/07/31 CRDT- 2026/10/28 00:37 PHST- 2026/05/04 00:00 [received] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/10/28 05:29 [medline] PHST- 2026/10/28 05:28 [pubmed] PHST- 2026/10/28 00:37 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - 10.1186/s12887-026-07412-2 [pii] AID - 7412 [pii] AID - 10.1186/s12887-026-07412-2 [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 31;26(1):1075. doi: 10.1186/s12887-026-07412-2. PMID- 42946529 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261027 IS - 1557-8224 (Electronic) IS - 1089-3261 (Linking) VI - 30 IP - 4 DP - 2026 Nov TI - Metabolic Dysfunction-Associated Steatotic Liver Disease in Children. PG - 987-1007 LID - S1089-3261(26)00071-1 [pii] LID - 10.1016/j.cld.2026.07.009 [doi] AB - Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease among children and adolescents worldwide. Pediatric MASLD is associated with significant morbidity during childhood, including progressive liver fibrosis and incident diabetes, and significantly increases risk of premature mortality in early adulthood. In comparison to MASLD in adults, youth-onset MASLD exhibits distinct histologic patterns, lacks well-validated noninvasive tests for risk stratification and approved pharmacotherapy, and may carry higher risk of long-term liver-related mortality. Critical areas of unmet need include improving rates of recommended screening, development of pediatric-specific risk stratification tools and developing more effective prevention and treatment strategies. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Yodoshi, Toshifumi AU - Yodoshi T AD - Division of Gastroenterology, Hepatology, Pancreatology, and Nutrition, Department of Pediatrics, Stead Family Children's Hospital, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. FAU - Xanthakos, Stavra AU - Xanthakos S AD - Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: stavra.xanthakos@cchmc.org. LA - eng PT - Journal Article PT - Review DEP - 20260904 PL - United States TA - Clin Liver Dis JT - Clinics in liver disease JID - 9710002 SB - IM MH - Humans MH - Child MH - *Fatty Liver/diagnosis/therapy/epidemiology/etiology MH - Risk Factors MH - Adolescent MH - Liver Cirrhosis/etiology/epidemiology MH - *Non-alcoholic Fatty Liver Disease/diagnosis/therapy/epidemiology MH - Obesity/epidemiology/complications MH - Diabetes Mellitus, Type 2/epidemiology/complications OTO - NOTNLM OT - Fibrosis OT - MASH OT - MASLD OT - Mortality OT - Obesity OT - Type 2 diabetes COIS- Disclosure Dr S. Xanthakos has served as a scientific advisor to Novo Nordisk and Madrigal. Dr T. Yodoshi has nothing to disclose. EDAT- 2026/10/27 23:28 MHDA- 2026/10/27 23:29 CRDT- 2026/10/27 21:54 PHST- 2026/10/27 23:29 [medline] PHST- 2026/10/27 23:28 [pubmed] PHST- 2026/10/27 21:54 [entrez] AID - S1089-3261(26)00071-1 [pii] AID - 10.1016/j.cld.2026.07.009 [doi] PST - ppublish SO - Clin Liver Dis. 2026 Nov;30(4):987-1007. doi: 10.1016/j.cld.2026.07.009. Epub 2026 Sep 4. PMID- 42945754 OWN - NLM STAT- Publisher LR - 20261027 IS - 1873-5487 (Electronic) IS - 0188-4409 (Linking) VI - 58 IP - 1 DP - 2026 Oct 27 TI - Validation of the Healthy Complementary Feeding Practices Index: A Novel Approach for Assessing Infant Feeding in Mexico. PG - 103535 LID - S0188-4409(26)00157-8 [pii] LID - 10.1016/j.arcmed.2026.103535 [doi] AB - OBJECTIVE: To develop and validate the Healthy Complementary Feeding Practices Index (HCFPI), a novel tool designed to assess adherence to Mexico's national dietary guidelines and inform the design of interventions to prevent malnutrition in infants aged 6-24 months. METHODS: The HCFPI was constructed using a literature-based selection of components, indicators, and scoring criteria. Content validity was evaluated using the Delphi method with experts. Internal consistency (Cronbach's alpha) and concurrent validity with dietary intake were examined in a cross-sectional sample from a Mexican birth cohort at 6, 12, and 24 months. RESULTS: The HCFPI comprises 13 components and 15 items that reflect key CF dimensions, and it achieved "acceptable" expert consensus during content validation. The index demonstrated "acceptable" internal consistency (alpha = 0.70) and meaningful correlations with optimal Complementary Feeding (CF) practices, such as breastfeeding, the timely introduction of solids, and the avoidance of both unhealthy salty foods and follow-up formulas. Furthermore, higher HCFPI scores were associated with better dietary quality, including higher fiber intake, greater protein and vitamin B12 adequacy, and lower added sugar intake. CONCLUSION: The HCFPI is a valid, reliable, and practical tool for evaluating adherence to CF recommendations and dietary quality in young children. Its framework offers a model that could be adapted to create similar indices in other countries using evidence-based national dietary guidelines. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Tercero-Gomez, Francia AU - Tercero-Gomez F AD - National Institute of Public Health, Center for Nutrition and Health Research. FAU - Ramirez-Silva, Ivonne AU - Ramirez-Silva I AD - National Institute of Public Health, Center for Nutrition and Health Research. Electronic address: ciarmir@insp.mx. FAU - Rivera, Juan A AU - Rivera JA AD - National Institute of Public Health, Center for population Health Research. FAU - Fuentes-Garcia, Ruth AU - Fuentes-Garcia R AD - Department of Mathematics, Faculty of Science, National Autonomus of Mexico, Mexico City, Mexico. FAU - Perez-Escamilla, Rafael AU - Perez-Escamilla R AD - Yale School of Public Health. Yale University, New Haven, CT. USA. FAU - Olvera-Mayorga, Gabriela AU - Olvera-Mayorga G AD - National Institute of Public Health, Center for Nutrition and Health Research; Nutrition Academic Area, Institute of Health Sciences, Autonomous University of the State of Hidalgo, Mexico. FAU - Barragan-Vazquez, Sofia AU - Barragan-Vazquez S AD - National Institute of Public Health, Center for Nutrition and Health Research; Nutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds, Woodhouse, Leeds, UK. LA - eng PT - Journal Article DEP - 20261027 PL - United States TA - Arch Med Res JT - Archives of medical research JID - 9312706 SB - IM OTO - NOTNLM OT - Complementary feeding OT - Diet quality OT - Index OT - Infant feeding practices OT - Validation EDAT- 2026/10/27 23:28 MHDA- 2026/10/27 23:28 CRDT- 2026/10/27 19:07 PHST- 2025/10/02 00:00 [received] PHST- 2026/08/10 00:00 [revised] PHST- 2026/09/23 00:00 [accepted] PHST- 2026/10/27 23:28 [medline] PHST- 2026/10/27 23:28 [pubmed] PHST- 2026/10/27 19:07 [entrez] AID - S0188-4409(26)00157-8 [pii] AID - 10.1016/j.arcmed.2026.103535 [doi] PST - aheadofprint SO - Arch Med Res. 2026 Oct 27;58(1):103535. doi: 10.1016/j.arcmed.2026.103535. PMID- 42942963 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261029 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 20 DP - 2026 Oct 16 TI - The Preterm Brain Is Also What It Eats: A Systematic Review of Nutrition and Neuroimaging Outcomes in Preterm Infants. LID - 10.3390/nu18203392 [doi] LID - 3392 AB - Background: Nutrition is one of the most modifiable determinants of brain development in preterm infants. Although increasing evidence supports associations between early nutritional exposures and neurodevelopment, studies remain heterogeneous regarding nutritional interventions, imaging biomarkers, and long-term outcomes. This systematic review aimed to summarize contemporary evidence on the relationship between nutrition and brain development in preterm infants using neuroimaging as the primary assessment tool while proposing an integrated translational framework to guide future research. Methods: Following a PECO framework, a systematic literature search was conducted in PubMed, Scopus, and CINAHL: population, infants born before 37 completed weeks of gestation; exposure, any enteral or parenteral nutritional exposure, supplementation strategy, fortification approach, or individualized nutritional intervention; comparator, an alternative nutritional strategy, lower or absent exposure, standard care or, when relevant, a term-born reference group; outcomes, MRI- or CUS-based measures of brain growth, maturation, connectivity, or injury. Studies reporting volumetric, morphometric, diffusion, connectivity, spectroscopy, or quantitative ultrasound outcomes were eligible. The methodology was adapted from the PROSPERO-registered review by Ottolini et al. Original studies published between 2020 and 2026 (1 January 2020-4 September 2026) evaluating nutritional exposures or interventions in preterm infants with magnetic resonance imaging (MRI) and/or cranial ultrasound (CUS) outcomes were included. Risk of bias was assessed using the Newcastle-Ottawa Scale (NOS), ROBINS-I and RoB 2 according to study design. Quantitative imaging studies were screened for eligibility for ATLAS assessment. Given the substantial heterogeneity in nutritional exposures, imaging protocols, timing of assessments, and neurodevelopmental outcomes, meta-analysis was not performed. Certainty of evidence was assessed at the level of each causal question and neuroimaging outcome domain using the GRADE framework. Randomized intervention evidence and observational exposure evidence were evaluated according to the design and target contrast contributing to each body of evidence. Judgments considered risk of bias, inconsistency, indirectness, imprecision, publication bias, and, where applicable, factors that could increase certainty. Statistical significance was not used to determine certainty, and studies arising from shared or partially overlapping parent populations were not counted as independent replication. Results: We found 33 reports that met the inclusion criteria: 4 evaluated randomized treatment contrasts, 5 non-randomized intervention comparisons, and 24 observational nutritional exposure analyses. Greater exposure to human milk and selected strategies involving early protein and lipid provision, docosahexaenoic acid, omega-3 fatty acids, and individualized nutritional support were associated in several studies with favorable MRI measurements, including larger total or regional brain volumes, more advanced white-matter maturation, and differences in structural or functional connectivity. Some studies also reported associations with later neurodevelopment. However, findings were not uniform, and GRADE certainty across outcome-specific nutrition-neuroimaging questions ranged from very low to low, principally because of risk of bias, imprecision, heterogeneous exposure and imaging definitions, and limited independent replication. Although causal inference cannot be directly drawn, neuroimaging may provide quantitative measures of brain development that can be investigated alongside long-term neurodevelopmental outcomes. We propose the Roadmap for Imaging-Guided Enhancement of Neurodevelopment (RIGEL), an integrative research framework combining imaging, molecular biomarkers, standardized neurodevelopmental assessment, and epidemiological evidence across developmental stages. RIGEL should be regarded as a hypothesis-generating research framework that requires prospective validation before any clinical implementation. FAU - Canepa, Maria Ester AU - Canepa ME AUID- ORCID: 0009-0004-7400-1724 AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Mother-Child Health, University of Genoa, 16132 Genoa, Italy. FAU - Prefumo, Federico AU - Prefumo F AUID- ORCID: 0000-0001-7793-714X AD - Obstetrics and Gynecology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy. FAU - Biagioli, Valentina AU - Biagioli V AUID- ORCID: 0009-0004-3021-6627 AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Mother-Child Health, University of Genoa, 16132 Genoa, Italy. FAU - Striano, Pasquale AU - Striano P AUID- ORCID: 0000-0002-6065-1476 AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Mother-Child Health, University of Genoa, 16132 Genoa, Italy. AD - Pediatric Neurology and Muscular Diseases Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy. FAU - Calandrino, Andrea AU - Calandrino A AUID- ORCID: 0000-0002-2710-1798 AD - Neonatal Intensive Care Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy. FAU - Ramenghi, Luca Antonio AU - Ramenghi LA AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Mother-Child Health, University of Genoa, 16132 Genoa, Italy. AD - Neonatal Intensive Care Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy. LA - eng PT - Journal Article PT - Review PT - Systematic Review DEP - 20261016 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Female MH - Humans MH - Infant, Newborn MH - *Brain/growth & development/diagnostic imaging MH - *Infant Nutritional Physiological Phenomena MH - *Infant, Premature/growth & development MH - Magnetic Resonance Imaging MH - *Neurodevelopment MH - *Neuroimaging MH - *Nutritional Status PMC - PMC13708710 OTO - NOTNLM OT - MRI OT - brain OT - development OT - growth OT - imaging OT - neonate OT - nutrition COIS- The authors declare no conflicts of interest. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 22:05 PMCR- 2026/10/16 CRDT- 2026/10/27 10:43 PHST- 2026/08/06 00:00 [received] PHST- 2026/09/12 00:00 [revised] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/27 22:05 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:43 [entrez] PHST- 2026/10/16 00:00 [pmc-release] AID - nu18203392 [pii] AID - nutrients-18-03392 [pii] AID - 10.3390/nu18203392 [doi] PST - epublish SO - Nutrients. 2026 Oct 16;18(20):3392. doi: 10.3390/nu18203392. PMID- 42942926 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261028 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 20 DP - 2026 Oct 13 TI - School-Based Rescued Produce Distribution, and Changes in Parental Fruit Intake and Household Dietary Behaviors: A Non-Randomized Controlled Cluster Trial. LID - 10.3390/nu18203355 [doi] LID - 3355 AB - Background/Objectives: Fruit and vegetable intake remains below recommended levels, particularly among families facing socioeconomic constraints. School-based food access interventions may improve household dietary behaviors. This study evaluated the association between participation in the "Leket Health" school-based rescued produce distribution program and changes in parental fruit and vegetable intake, nutrition-related parenting practices, and household food security. Children's fruit and vegetables intake was assessed as a secondary exploratory outcome. Methods: A non-randomized controlled cluster trial was conducted among parents (n = 281) of 4th-5th-grade students at three elementary schools in a peripheral town in Israel, with one school per study arm (three clusters in total). Schools were assigned to full intervention (biweekly fruit and vegetable boxes and nutrition education), partial intervention (boxes only), or control. Parent data were collected at baseline and after 7 months using both self-reported fruit and vegetable portions and a validated food frequency questionnaire (FFQ), food security questionnaire, and parental behavior questionnaire. Child intake was assessed using a study-specific FFQ. Primary analyses used a complete-case approach, supplemented by an allocation-based multiple-imputation sensitivity analysis among 269 identifiable participants. The trial was not registered in a public registry. Results: A total of 70% of enrolled participants completed the study. The two parental intake measures yielded discordant findings: categorical changes in parent-reported daily fruit servings differed across study groups in the complete-case analysis (p = 0.028), whereas FFQ-derived fruit and vegetable intake (g/day) showed no statistically significant between-group differences. The overall parenting-practices score showed no statistically significant change (p = 0.770) or between-group difference (p = 0.297). Household food insecurity increased from 8.7% to 14.3% and worsened across all study arms, with no significant between-group difference in deterioration (p = 0.810). No primary dietary endpoint was prespecified. In the allocation-based multiple-imputation analysis, adjusted follow-up fruit intake was higher than control by 0.38 portions/day (95% CI 0.04-0.71) in the full-intervention arm and 0.25 portions/day (95% CI -0.10 to 0.61) in the partial-intervention arm; estimates were attenuated under more adverse assumptions regarding missing outcomes. In an exploratory post-allocation adherence analysis, each additional produce box collected was associated with 6.7% higher odds of a parent-reported increase in fruit intake (OR = 1.067, 95% CI 1.003-1.135; p = 0.040). Among intervention participants, parent-reported improvements in nutrition-related parenting practices were associated with parent-reported increases in household vegetable variety (OR = 2.219, 95% CI 1.057-4.656; p = 0.035). These exploratory associations do not establish intervention effects. The overall parenting-practices score showed no statistically significant change (p = 0.770) or between-group difference (p = 0.297). Household food insecurity increased from 8.7% to 14.3% and worsened across all study arms, with no significant between-group difference in deterioration (p = 0.810). Among children, no significant changes were observed in FFQ-derived intake. Conclusions: Program participation was associated with higher parent-reported fruit servings, although the magnitude of between-arm differences varied across missing-data assumptions. No significant changes were observed in parental vegetable servings or FFQ-derived fruit and vegetable intake among parents or children. Given the single-school-per-arm design, these findings should be interpreted as exploratory and require confirmation in studies with multiple schools per arm. FAU - Hod-Ovadia, Smadar AU - Hod-Ovadia S AD - Department of Nutrition Sciences, Faculty of Health Sciences, Ariel University, Ariel 40700, Israel. AD - Leket Israel, Ra'anana 43650, Israel. FAU - Kilzi, Moran AU - Kilzi M AD - Department of Nutrition Sciences, Faculty of Health Sciences, Ariel University, Ariel 40700, Israel. AD - Leket Israel, Ra'anana 43650, Israel. FAU - Factor, Hagai AU - Factor H AD - Department of Psychology, Faculty of Humanities and Social Sciences, Ariel University, Ariel 40700, Israel. FAU - Boaz, Mona AU - Boaz M AUID- ORCID: 0000-0002-3920-7549 AD - Department of Nutrition Sciences, Faculty of Health Sciences, Ariel University, Ariel 40700, Israel. FAU - Kaufman-Shriqui, Vered AU - Kaufman-Shriqui V AUID- ORCID: 0000-0003-3190-4187 AD - Department of Nutrition Sciences, Faculty of Health Sciences, Ariel University, Ariel 40700, Israel. AD - The Center for Urban Health Solutions (C-UHS), St. Michael's Hospital, Toronto, ON M5B 1T8, Canada. LA - eng GR - Leket Israel/ GR - Ariel University/ PT - Journal Article DEP - 20261013 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Fruit MH - *Vegetables MH - Male MH - Female MH - Child MH - *Parents MH - *Feeding Behavior MH - Schools MH - Israel MH - Parenting MH - *Diet MH - Family Characteristics MH - *School Health Services MH - Food Supply MH - Food Security PMC - PMC13708734 OTO - NOTNLM OT - food rescue OT - food security OT - fruit and vegetable intake OT - nutrition education OT - nutrition equity OT - parental dietary behavior OT - produce distribution OT - school-based intervention COIS- Leket Israel funded the study and implemented the Leket Health intervention program. S.H.-O. and M.K. are employed by Leket Israel, the organization that operates the Leket Health program. This employment is disclosed as a competing interest. To support research independence, data were collected using structured questionnaires, and statistical analyses were conducted by an external statistician using de-identified data. The authors declare no other conflicts of interest. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 22:05 PMCR- 2026/10/13 CRDT- 2026/10/27 10:43 PHST- 2026/09/02 00:00 [received] PHST- 2026/10/07 00:00 [revised] PHST- 2026/10/09 00:00 [accepted] PHST- 2026/10/27 22:05 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:43 [entrez] PHST- 2026/10/13 00:00 [pmc-release] AID - nu18203355 [pii] AID - nutrients-18-03355 [pii] AID - 10.3390/nu18203355 [doi] PST - epublish SO - Nutrients. 2026 Oct 13;18(20):3355. doi: 10.3390/nu18203355. PMID- 42940723 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 10 DP - 2026 Oct 14 TI - Children's Perception of Parental Body Size and Its Association with Their Desire to Be Like the Parent. LID - 10.3390/children13101404 [doi] LID - 1404 AB - BACKGROUND: Childhood obesity is a major and growing public health challenge worldwide. Although parental misperception of children's weight is well documented, how children perceive their parents' body size and whether parental body size is associated with children's expressed desire to be like the parent have received little attention. We examined children's perception of parental body size and whether parental BMI was associated with their expressed desire to be like the parent in a primary care sample. METHODS: This single-center, cross-sectional study included 229 parent-child pairs consecutively recruited from a family medicine outpatient clinic in Turkiye between January and March 2026. Children aged 4-8 years rated the accompanying parent's body size and reported whether they wanted to be like that parent, while parents independently rated their own body size. The BMI-based Body Size Guide was used for all figure selections, and the classification derived from objectively measured parental BMI served as the primary reference. Agreement was evaluated using Cohen's kappa coefficients, associations were examined using multivariable logistic regression, and the children's spontaneous explanations were examined using qualitative content analysis. RESULTS: Parents showed moderate weighted agreement with the BMI-derived classification (weighted kappa = 0.536, 95% CI: 0.456-0.612; exact agreement: 59.4%), whereas children showed fair weighted agreement (weighted kappa = 0.315, 95% CI: 0.231-0.392; exact agreement: 42.8%). After adjustment for child age, child sex, child weight status, parent sex, and parent age, parental overweight (aOR = 0.353, 95% CI: 0.170-0.733) and parental obesity (aOR = 0.133, 95% CI: 0.057-0.307) were associated with lower odds of the child reporting a desire to be like the parent. After adjustment for child age, child sex, parent sex, and parent age, parental overweight (aOR = 2.818, 95% CI: 1.101-7.211) and parental obesity (aOR = 4.774, 95% CI: 1.816-12.546) were associated with higher odds of child overweight/obesity. Among the 53 children who provided an explanation, responses referred to body size, weight, health, appearance, affection, and identification with the parent, illustrating the broad interpretation of the question. CONCLUSIONS: Children aged 4-8 years were able to rate parental body size, although their agreement with the BMI-derived classification was limited. Children's expressed desire to be like the parent varied according to parental BMI; however, this broad question may reflect emotional, relational, behavioural, and appearance-related considerations rather than bodily resemblance alone. The open-ended responses provide context by showing that only some children spontaneously referred to body size or weight. These findings support further research using developmentally validated and stigma-sensitive measures to clarify how young children perceive parental body size and interpret questions about identification with a parent. FAU - Kurt, Abdullah Kaan AU - Kurt AK AUID- ORCID: 0000-0002-6302-6035 AD - Department of Family Medicine, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkiye. FAU - Karakullukcu, Serdar AU - Karakullukcu S AUID- ORCID: 0000-0001-7673-7699 AD - Department of Public Health, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkiye. LA - eng PT - Journal Article DEP - 20261014 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13703376 OTO - NOTNLM OT - body image OT - body size OT - child OT - parent-child relations OT - pediatric obesity COIS- The authors declare that they have no competing interests. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 11:33 PMCR- 2026/10/14 CRDT- 2026/10/27 10:37 PHST- 2026/09/07 00:00 [received] PHST- 2026/10/01 00:00 [revised] PHST- 2026/10/13 00:00 [accepted] PHST- 2026/10/27 11:33 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:37 [entrez] PHST- 2026/10/14 00:00 [pmc-release] AID - children13101404 [pii] AID - children-13-01404 [pii] AID - 10.3390/children13101404 [doi] PST - epublish SO - Children (Basel). 2026 Oct 14;13(10):1404. doi: 10.3390/children13101404. PMID- 42940677 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 10 DP - 2026 Oct 7 TI - Overlap of Subcutaneous Adiposity Across World Health Organization Body Mass Index-for-Age Categories and Anthropometric Correlates of Handgrip Strength in Children Aged 6-12 Years Participating in Organised Club Sport in Buenos Aires, Argentina. LID - 10.3390/children13101358 [doi] LID - 1358 AB - Background/Objectives: Body mass index (BMI) is the most widely used screening tool in paediatric nutritional assessment, but it does not measure body fat directly and conveys no information on muscular development. We aimed to (i) compare the sum of six skinfolds (Sigma6ST) across World Health Organization (WHO) BMI-for-age categories, accounting for age; (ii) quantify the distributional overlap of Sigma6ST between categories; (iii) examine how closely each individual skinfold tracks the remaining subcutaneous adiposity; and (iv) examine the associations of upper-limb girths with handgrip strength before and after adjustment for body size. Methods: This was a cross-sectional study of a convenience sample of 196 children (129 boys, 67 girls) aged 6-12 years engaged in organised club sport in Moron, Buenos Aires, Argentina. International Society for the Advancement of Kinanthropometry (ISAK)-certified anthropometrists measured six skinfolds and relaxed arm, corrected arm and forearm girths; handgrip strength was assessed with a digital dynamometer. Analyses used Kruskal-Wallis and Brunner-Munzel tests, age-adjusted log-linear models with robust standard errors, kernel-density overlap coefficients (OVLs) with bootstrap confidence intervals, and zero-order and partial Spearman correlations. Results: In this sample, 47.3% of boys and 43.3% of girls were classified as having overweight or obesity. Age distributions were similar across BMI categories, and Sigma6ST differed across categories after age adjustment (p < 0.001 in both sexes). Adjacent WHO categories nevertheless overlapped substantially (OVL = 0.44-0.57), and the two halves of the normal-weight range overlapped by up to 0.757. Single skinfolds correlated strongly with the sum of the remaining five (rho = 0.777-0.945) but estimated Sigma6ST with a median absolute error of 8.5-14.1%. Handgrip strength correlated most strongly with body size (stature in boys, rho = 0.723; body mass in girls, rho = 0.759). After adjustment for age, body mass and stature, it remained associated with corrected arm girth (partial rho = 0.346 and 0.336) but not with relaxed arm girth. Conclusions: BMI-for-age categories separate groups on average but carry limited information about an individual child's subcutaneous adiposity. Skinfolds and corrected arm girth are low-cost complements to BMI whose individual-level value requires validation against criterion methods. FAU - Gimenez, Mariano Jose AU - Gimenez MJ AUID- ORCID: 0009-0008-6135-3519 AD - Catedra de Nutricion y Deporte, Escuela de Nutricion, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121A6B, Argentina. AD - Red Iberoamericana de Investigadores en Antropometria Aplicada, 04120 Almeria, Spain. FAU - Herrera-Amante, Carlos Abraham AU - Herrera-Amante CA AUID- ORCID: 0000-0002-3645-3621 AD - Red Iberoamericana de Investigadores en Antropometria Aplicada, 04120 Almeria, Spain. AD - Laboratorio de Evaluacion y Cuidado del Estado Nutricio, Centro Universitario de Tonala, Division de Ciencias de la Salud, Universidad de Guadalajara, Tonala 45425, Jalisco, Mexico. FAU - Yanez-Sepulveda, Rodrigo AU - Yanez-Sepulveda R AUID- ORCID: 0000-0002-9311-6576 AD - Faculty of Education and Humanities, School of Sport Sciences, Universidad Andres Bello, Vina del Mar 2520000, Chile. AD - Department of Sport Sciences, Faculty of Sport and Health Sciences, Fit Generation Research Institute, AD500 Andorra la Vella, Andorra. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AUID- ORCID: 0000-0002-7412-7624 AD - School of Medicine, Universidad Espiritu Santo, Samborondon 092301, Ecuador. AD - Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno 5290000, Chile. LA - eng PT - Journal Article DEP - 20261007 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13702943 OTO - NOTNLM OT - anthropometry OT - body composition OT - body mass index OT - child OT - hand strength OT - paediatric obesity OT - skinfold thickness OT - youth sport COIS- M.J.G., C.A.H.-A., and R.Y.-S. are certified Level Three Anthropometrists (Instructors) by the International Society for the Advancement of Kinanthropometry (ISAK), who have received honoraria for teaching anthropometry courses and participating in international conferences. These professional interests relate to the field of anthropometry, which is the subject of the present manuscript, and are disclosed for full transparency; they did not influence the design, analysis or reporting of the study, and no author received any payment related to this manuscript. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 11:33 PMCR- 2026/10/07 CRDT- 2026/10/27 10:37 PHST- 2026/09/02 00:00 [received] PHST- 2026/09/22 00:00 [revised] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/27 11:33 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:37 [entrez] PHST- 2026/10/07 00:00 [pmc-release] AID - children13101358 [pii] AID - children-13-01358 [pii] AID - 10.3390/children13101358 [doi] PST - epublish SO - Children (Basel). 2026 Oct 7;13(10):1358. doi: 10.3390/children13101358. PMID- 42940674 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 10 DP - 2026 Oct 5 TI - Orthorexia Symptoms in Adolescents: Associations with Sociocultural Attitudes Toward Appearance and Body Composition. LID - 10.3390/children13101355 [doi] LID - 1355 AB - BACKGROUND/OBJECTIVES: Orthorexic symptoms in adolescence may be associated with sociocultural appearance influences, but their relationship with objective body composition remains unclear. This study examined associations between orthorexic symptoms, sociocultural attitudes toward appearance, and body composition in adolescents. METHODS: This cross-sectional study included 287 Polish secondary-school students aged 14-18 years. Orthorexic symptoms were assessed using the Dusseldorf Orthorexia Scale (DOS), sociocultural attitudes using the Sociocultural Attitudes Towards Appearance Questionnaire-3 (SATAQ-3), and body composition by bioelectrical impedance analysis. Correlation and multiple linear regression analyses were performed. RESULTS: DOS scores correlated positively with SATAQ-3 pressure/internalization (r = 0.407, p < 0.001), athletic internalization (r = 0.330, p < 0.001), and Information (r = 0.385, p < 0.001). These associations remained robust in Spearman sensitivity analyses. The regression model including four SATAQ-3 subscales, percentage body fat (PBF), sex, and age explained 19.2% of DOS-score variance (adjusted R(2) = 0.172; F(7.279) = 9.49, p < 0.001). Pressure/internalization (beta = 0.190, p = 0.053) and Information (beta = 0.162, p = 0.060) did not reach conventional statistical significance. The remaining predictors were not independently associated with DOS scores. CONCLUSIONS: Orthorexic symptom severity was associated with appearance-related sociocultural variables at the bivariate level, but individual predictors were not independently significant in the adjusted model. These findings identify sociocultural factors as relevant correlates without establishing causality or excluding a role for body composition. Longitudinal studies using adolescent-validated measures and direct assessments of digital exposure are needed. FAU - Kiciak, Agata AU - Kiciak A AUID- ORCID: 0000-0002-4531-2038 AD - Department of Food Technology and Quality Assessment, Department of Dietetics, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland. FAU - Staskiewicz, Wiktoria AU - Staskiewicz W AUID- ORCID: 0000-0003-2420-5935 AD - Department of Food Technology and Quality Assessment, Department of Dietetics, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland. FAU - Kuczka-Marek, Natalia AU - Kuczka-Marek N AUID- ORCID: 0009-0007-2144-6318 AD - Doctoral School, Medical University of Silesia in Katowice, 40-055 Katowice, Poland. FAU - Bialek-Dratwa, Agnieszka AU - Bialek-Dratwa A AUID- ORCID: 0000-0002-7798-6424 AD - Department of Human Nutrition, Department of Dietetics, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland. FAU - Sapala, Anna-Maria AU - Sapala AM AUID- ORCID: 0009-0009-2558-5600 AD - Department of Dietetics and Food Science, Faculty of Science, Natural and Technical Sciences, Jan Dlugosz University in Czestochowa, Aleja Armii Krajowej 13/15, 42-200 Czestochowa, Poland. FAU - Jaruga-Sekowska, Sylwia AU - Jaruga-Sekowska S AUID- ORCID: 0000-0003-0142-2013 AD - Department of Health Promotion, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, ul. Piekarska 18, 41-902 Bytom, Poland. FAU - Kardas, Marek AU - Kardas M AUID- ORCID: 0000-0002-4810-1025 AD - Department of Food Technology and Quality Assessment, Department of Dietetics, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland. AD - Food Industry School, Franciszkanska 13, 41-819 Zabrze, Poland. FAU - Barczynska, Renata AU - Barczynska R AUID- ORCID: 0000-0002-4161-6480 AD - Department of Dietetics and Food Science, Faculty of Science, Natural and Technical Sciences, Jan Dlugosz University in Czestochowa, Aleja Armii Krajowej 13/15, 42-200 Czestochowa, Poland. LA - eng PT - Journal Article DEP - 20261005 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13703725 OTO - NOTNLM OT - adolescent mental health OT - body image OT - orthorexia nervosa OT - sociocultural pressure COIS- The authors declare no conflicts of interest. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 11:33 PMCR- 2026/10/05 CRDT- 2026/10/27 10:37 PHST- 2026/08/17 00:00 [received] PHST- 2026/09/16 00:00 [revised] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/27 11:33 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:37 [entrez] PHST- 2026/10/05 00:00 [pmc-release] AID - children13101355 [pii] AID - children-13-01355 [pii] AID - 10.3390/children13101355 [doi] PST - epublish SO - Children (Basel). 2026 Oct 5;13(10):1355. doi: 10.3390/children13101355. PMID- 42940616 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 10 DP - 2026 Sep 24 TI - Health-Related Behaviors and BMI Across Three School Years: Annual Bayesian Network Patterns During the PETICA Childhood Obesity Prevention Program. LID - 10.3390/children13101298 [doi] LID - 1298 AB - Background/Objectives: This study examined annual probabilistic network structures among dietary habits, health-related attitudes, lifestyle behaviors, and body mass index (BMI) during implementation of the PETICA school-based program. Methods: This was a three-year prospective, uncontrolled school-based intervention with repeated measurements of the same cohort in Grades 2-4. The BMI analytic samples comprised 915 pupils in Grade 2 (461 boys, 454 girls; mean age 7.9 +/- 0.4), 840 in Grade 3 (429 boys, 411 girls; mean age 8.9 +/- 0.5), and 684 in Grade 4 (341 boys, 343 girls; mean age 9.9 +/- 0.4). BMI was recalculated from measured body mass and height and used as the continuous network outcome. BMI-for-age percentiles were retained for age- and sex-specific descriptive classification and sensitivity analysis. Separate score-based Bayesian networks were estimated for each grade. Network stability was assessed using 200 nonparametric bootstrap samples, with stable adjacency defined as a bootstrap frequency of at least 50%. Results: Fruit and vegetable intake formed a stable adjacency in all three grades, with bootstrap frequencies of 100.0% in Grade 2, 98.0% in Grade 3, and 99.0% in Grade 4. The sex of the pupil and computer/video-game use were stably connected in Grades 3 and 4 (100.0% in both grades). Stable connections among health-related attitudes were more prominent in later grades. In Grade 4, at-home breakfast consumption was connected with water intake (57.5%) and vegetable intake (52.0%). No behavioral adjacency with continuous BMI reached the prespecified 50% stability threshold in any grade. The largest subthreshold behavior-BMI signal was observed for at-home breakfast consumption in Grade 4 (39.0%). Conclusions: Selected relationships among reported health-related behaviors were reproducible across annual assessments, whereas direct behavior-BMI connections were year-specific and did not reach the stability threshold. The greater integration of attitudes and healthy habits in later grades is compatible with cumulative, age-adapted health education, but the absence of an untreated comparison group prevents attribution of these patterns to PETICA. The findings do not establish causal effects or program effectiveness, but may contribute to hypotheses generation for future evaluations of multi-component school-based obesityprevention programs. FAU - Cobal Pravdic, Sara AU - Cobal Pravdic S AUID- ORCID: 0000-0001-6956-6887 AD - Croatian Medical Association, Subiceva 9, 10000 Zagreb, Croatia. FAU - Vranesic Bender, Darija AU - Vranesic Bender D AD - Unit of Clinical Nutrition, Department of Internal Medicine, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia. FAU - Gajdos Kljusuric, Jasenka AU - Gajdos Kljusuric J AUID- ORCID: 0000-0001-6657-7337 AD - Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10000 Zagreb, Croatia. FAU - Kazazic, Ema AU - Kazazic E AD - School of Medicine, University of Zagreb, Salata 2, 10000 Zagreb, Croatia. FAU - Krznaric, Zeljko AU - Krznaric Z AD - Croatian Medical Association, Subiceva 9, 10000 Zagreb, Croatia. AD - Unit of Clinical Nutrition, Department of Internal Medicine, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia. AD - School of Medicine, University of Zagreb, Salata 2, 10000 Zagreb, Croatia. FAU - Kurtanjek, Zelimir AU - Kurtanjek Z AD - Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10000 Zagreb, Croatia. LA - eng GR - Croatian Medical Association/ PT - Journal Article DEP - 20260924 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13703612 OTO - NOTNLM OT - BMI OT - BMI-for-age percentiles OT - Bayesian networks OT - dietary habits OT - lifestyle behaviors OT - prospective study OT - public-health program "PETICA" COIS- The authors declare no conflicts of interest. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 11:33 PMCR- 2026/09/24 CRDT- 2026/10/27 10:36 PHST- 2026/08/03 00:00 [received] PHST- 2026/09/11 00:00 [revised] PHST- 2026/09/22 00:00 [accepted] PHST- 2026/10/27 11:33 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:36 [entrez] PHST- 2026/09/24 00:00 [pmc-release] AID - children13101298 [pii] AID - children-13-01298 [pii] AID - 10.3390/children13101298 [doi] PST - epublish SO - Children (Basel). 2026 Sep 24;13(10):1298. doi: 10.3390/children13101298. PMID- 42939470 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2079-7737 (Print) IS - 2079-7737 (Electronic) IS - 2079-7737 (Linking) VI - 15 IP - 20 DP - 2026 Oct 16 TI - Maternal Pharmaceutical Intake, Tobacco Smoking, and Environmental Pesticide Exposures: High-Resolution Serum Pesticide Screening, Longitudinal Fetal Ultrasound Biometry, and Postnatal Anogenital Distance in a Brazilian Cohort. LID - 10.3390/biology15201869 [doi] LID - 1869 AB - Maternal lifestyle exposures and pharmaceutical consumption during gestation represent key modulators of intrauterine growth and reproductive tract programming. This prospective cohort study evaluated the associations of maternal clinical history, medication use, and tobacco smoking with serial fetal ultrasound biometry, AGD, and postnatal infant anthropometry. A cohort of 51 pregnant women was prospectively enrolled during the first trimester (/=4.00, coefficient of variation /=80% ratings of 4 or 5. RESULTS: Thirty-three candidates met the retention rule; SPC9 did not. The retained indicators received uniformly high importance endorsement, but concordance in relative rankings was limited (Kendall's W: importance 0.115, feasibility 0.160, clarity 0.163). Individual-level Stage 3 confirmation distributions were not available in the submitted analytic record, and quantitative convergence across stages was not assessed. The exploratory, sample-relative importance-feasibility matrix assigned 10, 5, 10, and 8 indicators to its four quadrants; 11 of 33 indicators changed quadrant in at least one leave-one-expert-out analysis. CONCLUSION: The resulting curricular, extracurricular, peer, cultural, and institutional indicators specify school conditions that experts considered potentially relevant to habit support. The findings do not establish strong inter-expert consensus, a validated measurement instrument, actual habit formation, or causal effects. Complete-case selection, limited stakeholder representation, and incomplete process records restrict interpretation. More complete source documentation, stakeholder co-design, and prospective measurement and implementation studies are needed. CI - Copyright (c) 2026 Hu, Su, Han, Li, Wang, Liu, Xiong and Li. FAU - Hu, Shaojuan AU - Hu S AD - College of Physical Education and Sports Science, Hengyang Normal University, Hengyang, China. FAU - Su, Yi AU - Su Y AD - College of Physical Education and Sports Science, Hengyang Normal University, Hengyang, China. FAU - Han, Dong AU - Han D AD - Shenzhen No. 3 Senior High School, Shenzhen, China. FAU - Li, Liting AU - Li L AD - College of Physical Education and Sports Science, Hengyang Normal University, Hengyang, China. FAU - Wang, Ran AU - Wang R AD - College of Physical Education and Sports Science, Hengyang Normal University, Hengyang, China. FAU - Liu, Yihang AU - Liu Y AD - College of Physical Education and Sports Science, Hengyang Normal University, Hengyang, China. FAU - Xiong, Jie AU - Xiong J AD - College of Physical Education and Sports Science, Hengyang Normal University, Hengyang, China. FAU - Li, Xinyuan AU - Li X AD - College of Physical Education and Sports Science, Hengyang Normal University, Hengyang, China. LA - eng PT - Journal Article DEP - 20261009 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Adolescent MH - *Schools MH - Child MH - China MH - *Exercise/psychology MH - Delphi Technique MH - *Habits MH - Female MH - Male MH - *Adolescent Behavior/psychology PMC - PMC13690933 OTO - NOTNLM OT - China OT - adolescent OT - expert consultation OT - habit support OT - modified Delphi approach OT - physical activity OT - school health promotion COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/24 05:35 MHDA- 2026/10/25 03:36 PMCR- 2026/10/09 CRDT- 2026/10/24 04:55 PHST- 2026/08/08 00:00 [received] PHST- 2026/09/13 00:00 [revised] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/10/25 03:36 [medline] PHST- 2026/10/24 05:35 [pubmed] PHST- 2026/10/24 04:55 [entrez] PHST- 2026/10/09 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1962254 [doi] PST - epublish SO - Front Public Health. 2026 Oct 9;14:1962254. doi: 10.3389/fpubh.2026.1962254. eCollection 2026. PMID- 42920505 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261024 LR - 20261025 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 13 DP - 2026 TI - Development and temporal validation of a calibrated machine learning model for in-hospital blood culture positivity using routine clinical data. PG - 1956921 LID - 10.3389/fmed.2026.1956921 [doi] LID - 1956921 AB - BACKGROUND: Among hospitalized patients who have already undergone blood culture collection, routinely available clinical information may support early risk stratification while microbiological results are pending. We developed and temporally validated a calibrated machine learning model for in-hospital blood culture positivity. METHODS: This single-center retrospective study included 44,389 blood culture-related hospitalization records from January 2022 to September 2024. Records from 2022 to 2023 were used for model development and records from 2024 for temporal validation. The primary outcome was at least one laboratory-recorded positive blood culture between index collection and hospital discharge. A Platt-calibrated XGBoost model using demographic characteristics, routine laboratory variables, and missingness indicators was compared with procalcitonin-only and regression-based models. Performance was assessed using discrimination, calibration, threshold-specific metrics, decision curve analysis, and SHAP. RESULTS: The cohort included 3,555 outcome-positive records (8.01%). In temporal validation, the final XGBoost model achieved a ROC-AUC of 0.798 (95% CI, 0.784-0.813), a PR-AUC of 0.266, a Brier score of 0.0619, and a calibration slope of 1.061. At the 5% threshold, sensitivity was 0.877, specificity 0.570, and negative predictive value 0.983. XGBoost showed a modest improvement over logistic regression with missingness indicators, while an exploratory post hoc Age + PCT + BMI logistic comparator achieved a ROC-AUC of 0.757. Performance was stable in the new-patient validation subset but decreased within adult and pediatric subgroups (ROC-AUC 0.679 and 0.663, respectively). Age, procalcitonin, and body mass index were the dominant contributors. CONCLUSION: The calibrated model provided moderate discrimination and favorable calibration for hospitalization-level blood culture positivity risk stratification in the pooled temporal validation cohort. Performance varied across age groups, and much of the predictive information was concentrated in age, PCT, and BMI. The model does not predict the index culture result alone or diagnose clinically adjudicated bloodstream infection. Multicenter external and prospective validation using fixed prediction horizons and adjudicated outcomes is required before clinical implementation. CI - (c) 2026 Huang, Tan, Jiang, Yang, Wang and Huang. FAU - Huang, Tao AU - Huang T AD - Department of Pharmacy, The Affiliated Hospital, Southwest Medical University, Luzhou, China. AD - School of Pharmacy, Southwest Medical University, Luzhou, China. FAU - Tan, Zhenzhen AU - Tan Z AD - School of Pharmacy, Southwest Medical University, Luzhou, China. AD - Department of Pharmacy, The Hejiang People's Hospital, Luzhou, China. FAU - Jiang, Longyang AU - Jiang L AD - Department of Pharmacy, The Affiliated Hospital, Southwest Medical University, Luzhou, China. AD - School of Pharmacy, Southwest Medical University, Luzhou, China. FAU - Yang, Xuping AU - Yang X AD - Department of Pharmacy, The Affiliated Hospital, Southwest Medical University, Luzhou, China. AD - School of Pharmacy, Southwest Medical University, Luzhou, China. FAU - Wang, Shurong AU - Wang S AD - Department of Pharmacy, The Affiliated Hospital, Southwest Medical University, Luzhou, China. AD - School of Pharmacy, Southwest Medical University, Luzhou, China. FAU - Huang, Yilan AU - Huang Y AD - Department of Pharmacy, The Affiliated Hospital, Southwest Medical University, Luzhou, China. AD - School of Pharmacy, Southwest Medical University, Luzhou, China. LA - eng PT - Journal Article DEP - 20261009 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC13690682 OTO - NOTNLM OT - XGBoost OT - blood culture positivity OT - clinical risk stratification OT - electronic health records OT - machine learning OT - probability calibration OT - temporal validation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/24 05:35 MHDA- 2026/10/24 05:36 PMCR- 2026/10/09 CRDT- 2026/10/24 04:44 PHST- 2026/08/03 00:00 [received] PHST- 2026/09/22 00:00 [revised] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/24 05:36 [medline] PHST- 2026/10/24 05:35 [pubmed] PHST- 2026/10/24 04:44 [entrez] PHST- 2026/10/09 00:00 [pmc-release] AID - 10.3389/fmed.2026.1956921 [doi] PST - epublish SO - Front Med (Lausanne). 2026 Oct 9;13:1956921. doi: 10.3389/fmed.2026.1956921. eCollection 2026. PMID- 42919594 OWN - NLM STAT- In-Process LR - 20261029 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 10 DP - 2026 Oct 23 TI - Lifestyle intervention to improve outcomes in dichorionic twin pregnancies: study protocol for a multicentre randomised controlled trial with an integrated pilot study - the LIFETWIN trial. PG - e122541 LID - 10.1136/bmjopen-2026-122541 [doi] LID - e122541 AB - INTRODUCTION: Preterm birth and small-for-gestational-age (SGA) infants remain major contributors to neonatal morbidity, mortality and healthcare costs. Twin pregnancies account for a disproportionate share of these adverse outcomes, representing 18%-24% of all preterm births in Europe. Despite this high-risk profile, effective preventive strategies for twin pregnancies remain limited and mainly target cervical length. Emerging evidence suggests that maternal lifestyle factors, including diet, physical activity and stress management, may prolong gestational age and improve fetal growth. METHODS AND ANALYSIS: The LIFEstyle intervention to improve TWIN pregnancy (LIFETWIN) - study is a multicentre, open-label, randomised controlled trial. A total of 274 women with dichorionic twin pregnancies will be recruited across 15 sites in Belgium. The full trial will be preceded by an integrated pilot study conducted at four sites to assess feasibility using the RE-AIM framework. Participants will be randomised to standard care or a lifestyle intervention in addition to standard care. The intervention consists of eight midwife-led sessions between gestational weeks 16 and 36, focusing on a Mediterranean-type diet, physical activity, mindfulness and prenatal multivitamin supplementation. Data are collected at baseline, in late pregnancy, at delivery and at 6 weeks postpartum, using clinical records, physical examinations and validated questionnaires. The primary outcome is gestational age at delivery. Secondary outcomes include neonatal birth weight, SGA status, neonatal morbidity and mortality, neonatal intensive care unit admission and length of stay, maternal gestational weight gain, postpartum weight and quality of life. The primary outcome, gestational age at delivery, will be analysed using a linear mixed-effects model, accounting for study-site effects and potential clustering by intervention midwife within the intervention arm. Secondary outcomes will be analysed using models appropriate to the outcome type, including linear mixed models, generalised mixed models and frailty models. ETHICS AND DISSEMINATION: The trial has been approved by the central ethics committee of Leuven (identification number S68251) and by the local ethics committees of each participating site. The trial will be conducted in accordance with the Declaration of Helsinki. All results, whether positive, negative or inconclusive, will be disseminated at national or international scientific meetings and published in peer-reviewed scientific journals. TRIAL REGISTRATION NUMBER: NCT07270640. FAU - Lodewyckx, Katleen AU - Lodewyckx K AUID- ORCID: 0009-0000-6181-1649 AD - REALIFE Research Group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. FAU - Shafran, Yael Winter AU - Shafran YW AD - REALIFE Research Group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. FAU - Coucke, Birgit AU - Coucke B AUID- ORCID: 0000-0003-0285-6665 AD - REALIFE Research Group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - Academic Centre for Nursing and Midwifery (AccentVV), Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium. FAU - Put, Martien AU - Put M AUID- ORCID: 0009-0000-5891-636X AD - Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium. FAU - Lewi, Liesbeth AU - Lewi L AD - Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium. FAU - Bogaerts, Annick AU - Bogaerts A AUID- ORCID: 0000-0003-2718-4682 AD - REALIFE Research Group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - L-C&Y, KU Leuven Child & Youth Institute, KU Leuven, Leuven, Belgium. AD - University of Plymouth, Faculty of Health, Plymouth, UK. FAU - Smits, Tim AU - Smits T AD - Institute for Media Studies, Katholieke Universiteit Leuven Faculteit Sociale Wetenschappen, Leuven, Belgium. FAU - Noel, Laure AU - Noel L AD - Obstetrics and Gynecology Department, Centre Hospitalier Regional de la Citadelle, Liege, Belgium. FAU - Mesens, Tinne AU - Mesens T AD - Department of Obstetrics and Gynecology, Hospital East-Limburg, Genk, Belgium. FAU - Jani, Jacques AU - Jani J AUID- ORCID: 0000-0003-2252-342X AD - Department of Obstetrics and Gynecology, Brugmann University Hospital, Brussels, Belgium. FAU - Devlieger, Roland AU - Devlieger R AD - REALIFE Research Group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, Leuven, Belgium roland.devlieger@uzleuven.be. AD - Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium. LA - eng PT - Journal Article DEP - 20261023 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM PMC - PMC13711562 OTO - NOTNLM OT - Exercise OT - Life Style OT - Mindfulness OT - NUTRITION & DIETETICS OT - Pregnancy OT - Premature Birth OT - Twin COIS- Competing interests: None declared. EDAT- 2026/10/23 23:32 MHDA- 2026/10/23 23:32 PMCR- 2026/10/23 CRDT- 2026/10/23 21:03 PHST- 2026/10/23 23:32 [medline] PHST- 2026/10/23 23:32 [pubmed] PHST- 2026/10/23 21:03 [entrez] PHST- 2026/10/23 00:00 [pmc-release] AID - bmjopen-2026-122541 [pii] AID - 10.1136/bmjopen-2026-122541 [doi] PST - epublish SO - BMJ Open. 2026 Oct 23;16(10):e122541. doi: 10.1136/bmjopen-2026-122541. PMID- 42919389 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261025 IS - 1479-5868 (Electronic) IS - 1479-5868 (Linking) VI - 23 IP - 1 DP - 2026 Jul 25 TI - Identifying eating behaviour phenotype cut-off scores for childhood obesity: an individual participant data meta-analysis using the Child Eating Behaviour Questionnaire (CEBQ). LID - 10.1186/s12966-026-01951-8 [doi] LID - 98 AB - BACKGROUND: Weight management interventions targeting appetitive traits show promise in treating childhood obesity, yet a tool to identify appetitive phenotypes for personalised treatment is missing. The Child Eating Behaviour Questionnaire (CEBQ) is a widely used measure of eight parent-reported appetitive traits associated with childhood obesity. We aimed to explore the utility of the CEBQ for phenotyping childhood obesity and derive cut-off scores to support clinical decision-making. METHODS: This individual participant data meta-analysis combined cross-sectional data from 17 international studies (N = 15,273) on CEBQ scores and Body Mass Index Standard Deviation Scores from children (2-18 years). The potential of CEBQ subscales (Food Responsiveness, Enjoyment of Food, Emotional Over-eating, Desire to Drink, Satiety Responsiveness, Slowness in Eating, Emotional Under-eating, Food Fussiness) to discriminate weight status was explored in random-effect meta-analyses of Area Under the Curve (AUC) metrics. We explored heterogeneity across studies and age- and sex- specific subgroups. Cut-off scores were derived within subgroups using (a) the Youden's Index and (b) the point maximising specificity after a minimum sensitivity of 60%. We meta-analysed study-specific performance with the selected cut-offs to describe heterogeneity across studies. RESULTS: AUCs for CEBQ subscales ranged from 0.60 to 0.71. The magnitude and shape of associations between CEBQ scores and obesity varied by age and sex. Cut-off performance was generally better in middle- than early childhood. The best performing cut-off score of 2.6 was observed for females aged 7-12 years for Food Responsiveness (Sensitivity: 0.81 [95%CI 0.77, 0.85]; Specificity: 0.85 [95%CI 0.82, 0.88]). High heterogeneity in cut-off performance across studies and wide prediction intervals suggest the need to further investigate external validity. CONCLUSIONS: We provide the first empirically derived CEBQ subscale cut-offs to phenotype children with obesity based on weight-related eating behaviours. Cut-offs could support personalised treatment in clinical and research contexts. FUNDING: MC_UU_00006/6 and MC_UU_00006/5. CI - (c) 2026. The Author(s). FAU - Kudlek, Laura AU - Kudlek L AUID- ORCID: 0000-0003-0947-3640 AD - Institute of Metabolic Science Epidemiology, University of Cambridge, Cambridge, UK. laura.kudlek@ims.cam.ac.uk. AD - Centre for Preventive Medicine and Digital Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany. laura.kudlek@ims.cam.ac.uk. FAU - Smith, Andrea D AU - Smith AD AD - Institute of Metabolic Science Epidemiology, University of Cambridge, Cambridge, UK. FAU - Ruggiero, Cara F AU - Ruggiero CF AD - Institute of Metabolic Science Epidemiology, University of Cambridge, Cambridge, UK. FAU - Pennells, Lisa AU - Pennells L AD - Department of Health and Primary Care, University of Cambridge, Cambridge, UK. FAU - Kininmonth, Alice R AU - Kininmonth AR AD - School of Food Science and Nutrition, University of Leeds, Leeds, UK. AD - Leeds Institute for Data Analytics, University of Leeds, Leeds, UK. FAU - Steinsbekk, Silje AU - Steinsbekk S AD - Department of Psychology, Norwegian University of Science and Technology, Hogskoleringen, Norway. FAU - Jansen, Pauline W AU - Jansen PW AD - Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, Netherlands. FAU - Ahern, Amy L AU - Ahern AL AD - Institute of Metabolic Science Epidemiology, University of Cambridge, Cambridge, UK. FAU - McCarthy, Elaine K AU - McCarthy EK AD - School of Food and Nutritional Sciences, University College Cork, Cork, Ireland. FAU - Gross, Amy AU - Gross A AD - Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA. FAU - Viana, Victor AU - Viana V AD - Faculty of Food Sciences and Nutrition, University of Porto, Porto, Portugal. FAU - van Deutekom, Arend W AU - van Deutekom AW AD - Department of Paediatrics, Division of Paediatric Cardiology Erasmus MC-Sophia Children's Hospital Rotterdam, Rotterdam,, Netherlands. FAU - Spence, John C AU - Spence JC AD - Faculty of Kinesiology, Sport, & Recreation, University of Alberta, Edmonton, AB, Canada. FAU - Fisher, Jennifer Orlet AU - Fisher JO AD - Department of Social and Behavioral Sciences, College of Public Health, Temple University, Philadelphia, PA, USA. FAU - Hayes, Jacqueline AU - Hayes J AD - Alpert Medical School of Brown University and The Miriam Hospital, Providence, RI, USA. FAU - Haycraft, Emma AU - Haycraft E AD - School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK. FAU - Hardman, Charlotte A AU - Hardman CA AD - Department of Psychology, University of Liverpool, Liverpool, UK. FAU - Silveira, Patricia P AU - Silveira PP AD - Department of Psychiatry, McGill University, Montreal, Quebec, Canada. FAU - Emond, Jennifer A AU - Emond JA AD - Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth College, Lebanon, NH, USA. FAU - Eloranta, Aino-Maija AU - Eloranta AM AD - Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, Kuopio, Finland. FAU - Dos Passos Gomes, Darlise R AU - Dos Passos Gomes DR AD - Department of Nutrition, Federal University of Pelotas, Pelotas, RS, Brazil. FAU - Lumeng, Julie C AU - Lumeng JC AD - Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA. FAU - Cross, Matthew B AU - Cross MB AD - USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Bates, Houston, TX, 1100, USA. FAU - Carnell, Susan AU - Carnell S AD - Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA. FAU - Fildes, Alison AU - Fildes A AD - School of Psychology, University of Leeds, Leeds, UK. FAU - Llewellyn, Clare AU - Llewellyn C AD - Department of Behavioural Science and Health, University College London, London, UK. LA - eng GR - MC_UU_00006/6/MRC_/Medical Research Council/United Kingdom GR - MC_UU_00006/5/MRC_/Medical Research Council/United Kingdom GR - NIHR203312/National Institute for Health and Care Research/ GR - NIHR203312/National Institute for Health and Care Research/ GR - RG/F/23/110103/BHF_/British Heart Foundation/United Kingdom GR - PR:1948633/Economic and Social Research Council/ PT - Journal Article PT - Meta-Analysis DEP - 20260725 PL - England TA - Int J Behav Nutr Phys Act JT - The international journal of behavioral nutrition and physical activity JID - 101217089 SB - IM MH - Humans MH - Child MH - *Feeding Behavior/psychology MH - Phenotype MH - Surveys and Questionnaires MH - Female MH - Child, Preschool MH - Body Mass Index MH - *Pediatric Obesity/psychology/diagnosis MH - Male MH - Cross-Sectional Studies MH - Adolescent MH - *Child Behavior PMC - PMC13693115 OTO - NOTNLM OT - Behavioural obesity phenotypes OT - Child eating behaviour questionnaire (CEBQ) OT - Childhood obesity OT - Cut-off scores COIS- Declarations. Ethics approval and consent to participate: Ethical approval and consent to participate were obtained by original investigators for each included study. No additional ethical approval was obtained for this secondary analysis of original study data. Consent for publication: Not applicable. Competing interests: ALA is a member of the scientific advisory board for Weight Watchers and has undertaken consultancy for Menwell Health and Juniper (all payments to her institution). CAH reports research funding for work unrelated to the submitted manuscript from the American Beverage Association; membership of Global Nutrition Advisory Council for Mars; primary supervisor of PhD studentship funded by Coca-Cola; membership of UK Government's Food Standards Agency's Advisory Committee on Social Sciences; honoraria from International Sweeteners Association and International Food Information Council for invited talks. CL held funding from the UKRI Medical Research Council Grant to support an intervention based on child eating behaviour, involving eating behaviour phenotyping. All other authors have no competing interests to declare. EDAT- 2026/10/23 23:32 MHDA- 2026/10/24 05:35 PMCR- 2026/07/25 CRDT- 2026/10/23 20:52 PHST- 2026/01/09 00:00 [received] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/10/24 05:35 [medline] PHST- 2026/10/23 23:32 [pubmed] PHST- 2026/10/23 20:52 [entrez] PHST- 2026/07/25 00:00 [pmc-release] AID - 10.1186/s12966-026-01951-8 [pii] AID - 1951 [pii] AID - 10.1186/s12966-026-01951-8 [doi] PST - epublish SO - Int J Behav Nutr Phys Act. 2026 Jul 25;23(1):98. doi: 10.1186/s12966-026-01951-8. PMID- 42913715 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261025 IS - 2190-6009 (Electronic) IS - 2190-5991 (Print) IS - 2190-5991 (Linking) VI - 17 IP - 5 DP - 2026 Oct TI - Machine Learning Integrating Quantitative MRI and Clinical Features Predicts Loss of Ambulation in Duchenne Muscular Dystrophy. LID - e70413 [pii] LID - 10.1002/jcsm.70413 [doi] AB - BACKGROUND: Loss of ambulation (LOA) is a key milestone in Duchenne muscular dystrophy (DMD) with highly variable timing, complicating clinical counselling and trial design. Quantitative MRI non-invasively assesses muscle fat infiltration, yet few models have integrated MRI with clinical variables for individualized LOA prediction. We aimed to develop and validate a machine-learning model integrating quantitative MRI and clinical features to predict time to LOA and to derive interpretable, individualized risk estimates and candidate thresholds. METHODS: This prospective study enrolled 188 boys with DMD (median age 9.10 years). Quantitative MRI parameters (T1, T2, fat fraction [FF]) of 19 hip/thigh muscles and clinical variables were measured. Patients were randomly split into training (80%) and test (20%) sets. Feature selection used LASSO, Boruta and recursive feature elimination based on random survival forest (RSF). Three survival models were compared: RSF and a ridge-penalised Cox model (both integrating clinical and MRI-derived features) and a multivariable Cox model restricted to clinical variables. Performance was assessed by concordance index (C-index), time-dependent area under the curve (AUC), integrated Brier score (IBS) and decision curve analysis at 12, 24, 36 and 48 months. RESULTS: Over median 43.5 months follow-up, 66 patients (35.1%) experienced LOA. Six predictors were retained: NSAA score, MRC%, age and three FF parameters (rectus femoris, vastus lateralis, obturator internus). In the test set (n = 40, 15 events), RSF achieved a C-index of 0.870 (95% CI, 0.764-0.957), outperforming the clinical Cox (0.804) and ridge Cox (0.853) model. Time-dependent AUCs of the RSF model were 0.984, 0.971, 0.913 and 0.850 at 12, 24, 36 and 48 months. RSF showed the best calibration, with the lowest IBS (0.076, 95% CI: 0.052-0.111), followed closely by the ridge Cox model (0.078) and the clinical Cox model (0.109). RSF stratified patients into low-risk, intermediate-risk and high-risk groups; no LOA events occurred in the low-risk group, with annual event rates were 7.2% and 34.6% in the intermediate- and high-risk groups (log-rank p = 0.0025). SHAP analysis identified exploratory thresholds (NSAA < 14.55, MRC% < 68.36%, rectus femoris FF > 32.30%, vastus lateralis FF > 58.00%, obturator internus FF > 7.43%). An interactive web application enables individualized risk prediction (https://westcndmd-timer-loa-risk-prediction-tool-8cygtrrbykvd9snmfcnhrp.streamlit.app/). CONCLUSIONS: A machine-learning-based RSF model integrating quantitative MRI FF metrics and clinical variables exhibited favourable predictive performance for time to LOA in DMD across short- and long-term horizons. It provided interpretable, individualized risk estimates and was deployed as an online tool to support clinical decision-making and trial enrichment. CI - (c) 2026 The Author(s). Journal of Cachexia, Sarcopenia and Muscle published by Wiley Periodicals LLC. FAU - Liu, Chuan AU - Liu C AUID- ORCID: 0000-0002-8126-7684 AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Song, Yu AU - Song Y AUID- ORCID: 0000-0002-1198-0732 AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Wan, Jiayu AU - Wan J AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Xu, Ting AU - Xu T AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Zhang, Xinyuan AU - Zhang X AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Yan, Yiqiao AU - Yan Y AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Fu, Hang AU - Fu H AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Cai, Xiaotang AU - Cai X AUID- ORCID: 0000-0001-8940-8253 AD - Department of Rehabilitation and Department of Pediatric Neurology, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Guo, Yingkun AU - Guo Y AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Wang, Yun AU - Wang Y AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Xu, Huayan AU - Xu H AUID- ORCID: 0000-0003-0801-0695 AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. LA - eng GR - HF-CSC2019B01/Clinical Research Funding of Chinese Society of Cardiovascular Disease (CSC)/ GR - 2022-GH03-00011-HZ/Project of Chengdu Science and Technology/ GR - 82572196/National Natural Science Foundation of China/ GR - 82471970/National Natural Science Foundation of China/ GR - 824B2052/National Natural Science Foundation of China/ GR - 82402250/National Natural Science Foundation of China/ GR - 825B2052/National Natural Science Foundation of China/ GR - 2026NSFSCZY0011/Key Project of Natural Science Foundation of Sichuan Province/ GR - 2026NSFSC0584/Natural Science Foundation of Sichuan Province/ GR - 2026-YF08-00166-GX/Chengdu Science and Technology Program/ GR - 2026-XT00-00013-GX/Chengdu Science and Technology Program/ PT - Journal Article PL - Germany TA - J Cachexia Sarcopenia Muscle JT - Journal of cachexia, sarcopenia and muscle JID - 101552883 SB - IM MH - Humans MH - *Muscular Dystrophy, Duchenne/diagnostic imaging/physiopathology/diagnosis MH - *Magnetic Resonance Imaging/methods MH - *Machine Learning MH - Male MH - Child MH - Prospective Studies MH - *Walking MH - Random Forest MH - Predictive Learning Models MH - Prognosis PMC - PMC13690469 OTO - NOTNLM OT - Duchenne muscular dystrophy OT - fat fraction OT - loss of ambulation OT - machine learning OT - quantitative MRI OT - random survival forest COIS- The authors declare no conflicts of interest. EDAT- 2026/10/23 23:31 MHDA- 2026/10/23 23:32 PMCR- 2026/10/22 CRDT- 2026/10/23 17:59 PHST- 2026/09/07 00:00 [revised] PHST- 2026/06/25 00:00 [received] PHST- 2026/10/13 00:00 [accepted] PHST- 2026/10/23 23:32 [medline] PHST- 2026/10/23 23:31 [pubmed] PHST- 2026/10/23 17:59 [entrez] PHST- 2026/10/22 00:00 [pmc-release] AID - e70413 [pii] AID - JCSM70413 [pii] AID - 10.1002/jcsm.70413 [doi] PST - ppublish SO - J Cachexia Sarcopenia Muscle. 2026 Oct;17(5):e70413. doi: 10.1002/jcsm.70413. PMID- 42912754 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261025 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 10 DP - 2026 TI - Determine and compare limb specific predictors based on the foot pressure index of right and left foot among young adults in Saudi Arabia using machine learning models. PG - e0360520 LID - 10.1371/journal.pone.0360520 [doi] LID - e0360520 AB - Foot posture is a key determinant of limb-biomechanics, gait balance as well as functional mobility. Usage of foot pressure index (FPI) is widespread to but the determinants of FPI without accounting to the left right foot differences. Therefore, identifying limb-specific determinants would enhance screening accuracy and help in more targeted interventions. The objective of the study was to determine and compare limb specific predictors based on the foot pressure index of right and left foot among young adults using machine learning models. A total of 581 (290 females and 291 males) 18-25-year-old young adults were assessed on anthropometric measures, joint hyper mobility and functional mobility. Using SAS-Viya, separate entropy-based decision trees, along with logistic regression models were developed and model performance was evaluated using validation-test accuracy and area under the curve (AUC). Decision tree models outperformed logistic regression for both FPI-Left (FPI-L) and FPI-Right (FPIR). FPIR was primarily predicted by joint hyper mobility, followed by stair ascent time, stability as well as BMI with stronger influence of both structural and load related factors. FPIL was predicted by closed-eye balance along BMI, open eye balance, stair ascent, Beighton score, underscoring the role of sensory motor control. The findings of the study reflect that young adults foot posture is complex, limb specific interactions among anthropometric, functional and sensory factors. CI - Copyright: (c) 2026 Samuel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Samuel, Paul Silvian AU - Samuel PS AUID- ORCID: 0000-0002-4920-6347 AD - Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. FAU - Thomas, Resmi Ann AU - Thomas RA AD - College of Business, Centennial College, Toronto, Canada. FAU - Kakaraparthi, Venkata Nagaraj AU - Kakaraparthi VN AD - Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. FAU - Reddy, Ravi Shankar AU - Reddy RS AD - Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. FAU - Alshahrani, Mastour Saeed AU - Alshahrani MS AD - Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. FAU - Alnakhli, Hani H AU - Alnakhli HH AD - Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. FAU - Alkhamis, Batool Abdulelah AU - Alkhamis BA AD - Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. FAU - Gular, Kumar AU - Gular K AD - Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. LA - eng PT - Comparative Study PT - Journal Article DEP - 20261023 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - *Machine Learning MH - *Foot/physiology MH - Pressure MH - Young Adult MH - Saudi Arabia MH - Male MH - Adolescent MH - Adult MH - Gait/physiology MH - Biomechanical Phenomena MH - Predictive Learning Models PMC - PMC13693902 COIS- The authors have declared that no competing interests exist. EDAT- 2026/10/23 18:31 MHDA- 2026/10/23 18:32 PMCR- 2026/10/23 CRDT- 2026/10/23 13:45 PHST- 2026/04/17 00:00 [received] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/23 18:32 [medline] PHST- 2026/10/23 18:31 [pubmed] PHST- 2026/10/23 13:45 [entrez] PHST- 2026/10/23 00:00 [pmc-release] AID - PONE-D-26-17999 [pii] AID - 10.1371/journal.pone.0360520 [doi] PST - epublish SO - PLoS One. 2026 Oct 23;21(10):e0360520. doi: 10.1371/journal.pone.0360520. eCollection 2026. PMID- 42910905 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261023 IS - 1536-7290 (Electronic) IS - 1536-7290 (Linking) VI - 26 IP - 11 DP - 2026 Nov TI - Age-Related Patterns of Relative Energy Deficiency in Sport (REDs) Symptoms and Key Performance Factors in Adolescent Biathletes. LID - e70273 [pii] LID - 10.1002/ejsc.70273 [doi] AB - Relative Energy Deficiency in Sport (REDs) impairs health and performance, but age-related patterns in its emergence remain unclear. This study examines RED symptoms in adolescent biathletes at season-start and their link to end-of-season performance. A national cross-sectional study including prospective performance registration recruited biathletes to complete validated questionnaires, followed by clinical interviews if eating disorders (EDs) were indicated. Athletes >/= 18 years were invited for physical laboratory assessments. End-of-season results were retrieved from open records. Analyses were performed by elastic net regression to identify the most stable predictors of performance, which were finally included in a linear regression model. Seventy-two athletes (55% females) with mean (SD) age 17.8 (1.4) years, 13.3 (3.3) training hours/week, and representing median (min, max) tier 3.0 (2, 5) were included. Prevalence in symptoms of low energy availability (LEA) was 18%, REDs 32%, EDs 11% (20% among females), and of depression 15%. Among 28 athletes (43% female) completing laboratory assessments, 11% had low BMD and /= 18 years who completed laboratory testing, 11% had low bone mineral density, and up to 25% showed clinical metabolic abnormalities. Symptoms of REDs and mental health concerns were more common in females and were more prevalent in the older age groups, peaking around 18 years. Better end-of-season performance was linked to higher training volume, fewer absences due to illness or injury, and lower RED severity. Higher body fat percentage and cholesterol levels were associated with poorer results. The findings highlight the importance of regular health screening, education and coaching to safeguard young athletes. OABL- eng OTO - NOTNLM OT - adolescent athletes OT - eating disorders OT - low energy availability OT - mental health OT - performance determinants EDAT- 2026/10/23 18:31 MHDA- 2026/10/23 18:32 CRDT- 2026/10/23 12:30 PHST- 2026/09/29 00:00 [revised] PHST- 2026/02/19 00:00 [received] PHST- 2026/10/03 00:00 [accepted] PHST- 2026/10/23 18:32 [medline] PHST- 2026/10/23 18:31 [pubmed] PHST- 2026/10/23 12:30 [entrez] AID - e70273 [pii] AID - 10.1002/ejsc.70273 [doi] PST - ppublish SO - Eur J Sport Sci. 2026 Nov;26(11):e70273. doi: 10.1002/ejsc.70273. PMID- 42909075 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261023 LR - 20261024 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Cultural adaptation and validation of the SESMEB scale for assessing the influence of social media on the eating habits of adolescents in the city of Doboj, Bosnia and Herzegovina. PG - 1935743 LID - 10.3389/fnut.2026.1935743 [doi] LID - 1935743 AB - INTRODUCTION: Marketing of foods high in fat, sugar and salt shapes the food preferences and intake of children and adolescents. The primary aim of this study was to culturally adapt and validate the Scale of Effects of Social Media on Eating Behavior (SESMEB) for assessing the influence of social media on the eating habits of adolescents in the Republic of Srpska, Bosnia and Herzegovina, and to examine whether this influence differs by sex, place of residence, nutritional status and school attended. METHODS: A cross-sectional study was conducted in six secondary schools in the city of Doboj in May 2023 and included 362 adolescents attending the third and fourth grades. The SESMEB scale was cross-culturally adapted into Serbian through forward and back-translation, expert panel review and pre-testing. Internal consistency was assessed by Cronbach's alpha and corrected item-total correlations, the factor structure by exploratory factor analysis, and test-retest reproducibility in a subsample of 14 respondents by the intraclass correlation coefficient (ICC). Group differences were tested by t-test and ANOVA. RESULTS: The adapted scale showed good internal consistency (Cronbach's alpha = 0.865), with corrected item-total correlations from 0.346 to 0.638; the data were suitable for factor analysis (KMO = 0.857; Bartlett's test chi (2) (153) = 2312.380; p < 0.001). Exploratory factor analysis identified three subscales accounting for 51.5% of the variance, which could not be clearly separated. Test-retest analysis showed no significant difference between administrations (t = 0.552; p = 0.591; ICC > 0.7). Mean scores for all 18 items denoted no perceived influence, with 55.0-76.8% of respondents reporting no effect on their food-related attitudes and practices. Girls scored higher than boys for following nutrition-related content (p < 0.05) and for the increase in the desire to eat (p = 0.048); differences also emerged by place of residence (p = 0.041) and school attended (p = 0.008; p = 0.004). CONCLUSION: Adopted version of the SESMEB scale is a reliable instrument for assessing the perceived effects of social media on adolescent eating behavior. Most respondents reported no such influence, even though this population is intensively exposed to digital marketing of energy-dense products, suggesting that self-report may underestimate the actual effect of that exposure. CI - Copyright (c) 2026 Stojisavljevic, Jotic Ivanovic, Mijovic, Nikolic, Niskanovic and Joksimovic. FAU - Stojisavljevic, Dragana AU - Stojisavljevic D AD - Department of Nutrition, The Public Health Institute of Republic of Srpska, Banja Luka, Bosnia and Herzegovina. AD - Department of Public Health, Faculty of Medicine, University of Banja Luka, Banja Luka, Bosnia and Herzegovina. FAU - Jotic Ivanovic, Marina AU - Jotic Ivanovic M AD - Department of Family Medicine, Primary Health Care Centre, Doboj, Bosnia and Herzegovina. FAU - Mijovic, Biljana AU - Mijovic B AD - Department of Primary Health Care and Public Health, Faculty of Medicine, University of East Sarajevo, Foca, Bosnia and Herzegovina. FAU - Nikolic, Maja AU - Nikolic M AD - Department of Social Medicine, Faculty of Medicine, University of Nis, Nis, Serbia. FAU - Niskanovic, Jelena AU - Niskanovic J AD - Department of Psychology, Faculty of Philosophy, University of Banja Luka, Banja Luka, Bosnia and Herzegovina. FAU - Joksimovic, Bojan AU - Joksimovic B AD - Department of Preclinical Subjects (Pathological Physiology), Faculty of Medicine, University of East Sarajevo, Foca, Bosnia and Herzegovina. LA - eng PT - Journal Article DEP - 20261007 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13683706 OTO - NOTNLM OT - SESMEB questionnaire OT - adolescents OT - eating behavior OT - food marketing OT - social networks COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/23 11:32 MHDA- 2026/10/23 11:33 PMCR- 2026/10/07 CRDT- 2026/10/23 07:21 PHST- 2026/07/12 00:00 [received] PHST- 2026/09/07 00:00 [revised] PHST- 2026/09/17 00:00 [accepted] PHST- 2026/10/23 11:33 [medline] PHST- 2026/10/23 11:32 [pubmed] PHST- 2026/10/23 07:21 [entrez] PHST- 2026/10/07 00:00 [pmc-release] AID - 10.3389/fnut.2026.1935743 [doi] PST - epublish SO - Front Nutr. 2026 Oct 7;13:1935743. doi: 10.3389/fnut.2026.1935743. eCollection 2026. PMID- 42908670 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261023 LR - 20261025 IS - 2773-0654 (Electronic) IS - 2773-0654 (Linking) VI - 5 IP - 6 DP - 2026 Dec TI - Beyond Accuracy: Machine Learning Models for Predicting the Presence of Permanent Molar Caries in U.S. Children and Adolescents With Fairness Consideration. PG - 100506 LID - 10.1016/j.focus.2026.100506 [doi] LID - 100506 AB - INTRODUCTION: Although predictors of dental caries have been previously explored, a comprehensive understanding of factors influencing permanent-molar decay in U.S. children and adolescents, especially with respect to racial and ethnic biases, remains limited. This study aims to develop and evaluate machine learning models incorporating algorithmic fairness to predict caries in permanent molars. METHODS: Data from the National Health and Nutrition Examination Survey were analyzed using the 2011-2014 cycles for training and validation and the 2015-2016 cycle for testing. The primary outcome was decayed, missing, and filled teeth in at least 1 permanent molar, dichotomized to represent the presence or absence of caries. Candidate predictors included demographic characteristics, dietary factors, laboratory and examination measures, behaviors, and lifestyle indicators. Three machine learning models (logistic regression, random forest, and XGBoost) were implemented and compared using the area under the receiver operating characteristic curve, accuracy, sensitivity, and specificity. Fairness was quantified by comparing group-specific true-positive rates and false-positive rates across race/ethnicity over 10 cross-validation folds, using Shapiro-Wilk tests and paired tests to assess subgroup gaps and pre/postmitigation changes. To mitigate disparities, an in-processing equalized-odds constraint was applied through an exponentiated-gradient reduction framework. Sensitivity analyses using National Health and Nutrition Examination Survey weights were also conducted. RESULTS: Among 5,710 participants aged 6-19 years, 37.30% had caries in at least 1 permanent molar. Logistic regression achieved the highest premitigation area under the receiver operating characteristic curve (78.50%). SHAP (SHapley Additive exPlanations) analyses identified age, family income, BMI, and household education as key contributors. Fairness evaluation indicated minimal equal-opportunity gaps but showed evidence of equalized-odds violations across race/ethnicity. After mitigation, race/ethnicity-related disparities decreased across models, with varying performance trade-offs. XGBoost and random forest maintained stable area under the receiver operating characteristic curve values in both unweighted ( approximately 77%-78%) and survey-weighted ( approximately 75%-77%) evaluations. In contrast, logistic regression showed a substantial decline in unweighted area under the receiver operating characteristic curve (78.50%-65.53%) and a marked reduction in recall and F1 score, whereas changes under weighted evaluation were more modest (77.91%-76.54%). CONCLUSIONS: Machine learning models effectively predicted dental caries in children and adolescents using National Health and Nutrition Examination Survey data. Applying equalized-odds constraints reduces disparities across models, although with varying fairness-performance trade-offs. These findings highlight the importance of tailoring bias mitigation strategies to clinical priorities, balancing equitable outcomes and predictive utility, and they can be used to inform policy and better design-targeted interventions to improve oral health. CI - (c) 2026 The Author(s). FAU - Deb, Pritam AU - Deb P AD - Department of Industrial and Systems Engineering, Kennesaw State University, Marietta, Georgia. FAU - Li, Lin AU - Li L AD - Department of Industrial and Systems Engineering, Kennesaw State University, Marietta, Georgia. FAU - Scherrer, Christina R AU - Scherrer CR AD - Department of Industrial and Systems Engineering, Kennesaw State University, Marietta, Georgia. LA - eng GR - R15 DE031428/DE/NIDCR NIH HHS/United States GR - R21 DE032149/DE/NIDCR NIH HHS/United States PT - Journal Article DEP - 20260509 PL - United States TA - AJPM Focus JT - AJPM focus JID - 9918487585606676 PMC - PMC13683022 OTO - NOTNLM OT - Dental caries OT - children and adolescents OT - fairness OT - machine learning OT - prediction EDAT- 2026/10/23 05:32 MHDA- 2026/10/23 05:33 PMCR- 2026/05/09 CRDT- 2026/10/23 02:36 PHST- 2026/10/23 05:33 [medline] PHST- 2026/10/23 05:32 [pubmed] PHST- 2026/10/23 02:36 [entrez] PHST- 2026/05/09 00:00 [pmc-release] AID - S2773-0654(26)00032-5 [pii] AID - 100506 [pii] AID - 10.1016/j.focus.2026.100506 [doi] PST - epublish SO - AJPM Focus. 2026 May 9;5(6):100506. doi: 10.1016/j.focus.2026.100506. eCollection 2026 Dec. PMID- 42908574 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261023 LR - 20261024 IS - 2399-3529 (Electronic) IS - 2399-3529 (Linking) VI - 2026 IP - 4 DP - 2026 TI - In vitro incubation of human sperm does not change DNA methylation. PG - hoag079 LID - 10.1093/hropen/hoag079 [doi] LID - hoag079 AB - STUDY QUESTION: Is DNA methylation in mature spermatozoa affected by different culture media? SUMMARY ANSWER: Incubation of mature spermatozoa in hydrogen peroxide (H(2)O(2)) or palmitate for 24 h did not alter the DNA methylome. WHAT IS KNOWN ALREADY: Children conceived through ART face a higher risk of disorders linked to abnormal DNA methylation. As culture media can modulate DNA methylation in somatic cells, abnormal DNA methylation after ART may be caused by factors present in culture media during sperm incubation. STUDY DESIGN SIZE DURATION: Sperm from four donors underwent targeted shotgun proteomics analysis, focusing on protein size ranges that include epigenetic modifying enzymes. Additionally, sperm samples from 15 men were incubated for 24 h in either standard media, media with H(2)O(2), or media containing palmitate, two media known to induce acute DNA methylation changes in somatic cells. DNA methylation profiles of these incubated sperm samples were then compared to those of pre-incubation sperm using Reduced Representation Bisulfite Sequencing (RRBS). PARTICIPANTS/MATERIALS SETTING METHODS: Sperm samples were obtained from 15 healthy Caucasian men aged 20-40 years. Participants using prescription medications daily or with a history of testicular disease were excluded. Motile sperm were isolated through the swim-up technique. Protein analysis was conducted via in-gel digestion followed by mass spectrometry. DNA methylation was evaluated using RRBS and validated for select genomic regions with targeted bisulfite pyrosequencing. MAIN RESULTS AND THE ROLE OF CHANCE: Proteomic analysis returned 1930 proteins, including 144 newly identified proteins. Consistent with previous studies, we confirmed the presence of DNA methyltransferase 1 (DNMT1), while de novo methyltransferases DNMT3A and DNMT3B were not detected. Incubation in control, H(2)O(2), and palmitate media all led to decreased sperm motility, with the decline occurring the fastest under the H(2)O(2) condition. Sperm DNA methylation remained unchanged across all three culture conditions. LARGE SCALE DATA: N/A. LIMITATIONS REASONS FOR CAUTION: RRBS analysis covers only a portion of the genome, so DNA methylation changes in unexamined regions cannot be excluded, particularly at repeated regions of the genome. Moreover, since this study tested only three culture media conditions, it remains possible that other media formulations could impact DNA methylation. WIDER IMPLICATIONS OF THE FINDINGS: This study indicates that the DNA methylome of mature human spermatozoa is stable despite the presence of DNA methylation machinery components. These results imply that DNA methylation changes in response to environmental stress are more likely to happen during earlier stages of spermatogenesis. While the various culture media used in ART are unlikely to alter the DNA methylation patterns of individual sperm cells, the possibility that certain sperm with specific methylation signatures are selectively favored cannot be ruled out. FUNDING: This work was supported by a Challenge Programme Grant from the Novo Nordisk Foundation (NNF18OC0033754) to the Gametic Epigenetics Consortium against Obesity (GECKO). The Novo Nordisk Foundation Center for Basic Metabolic Research is an independent research center at the University of Copenhagen, partially funded by an unrestricted donation from the Novo Nordisk Foundation (NNF18CC0034900). This work was supported by the French Government (National Research Agency, ANR) through the 'Investments for the Future' programs LABEX SIGNALIFE ANR-11-LABX-0028-01 and IDEX UCAJedi ANR-15-IDEX-01. DISCLOSURES: R.B. is a recipient of research funding granted by the Novo Nordisk Foundation. E.A. is a shareholder of ExSeed Health Ltd. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. FAU - Kjoller, Emma Tykesson AU - Kjoller ET AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Dumargne, Marie-Charlotte AU - Dumargne MC AD - Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, Inserm and Universite Cote d'Azur, Valbonne, France. FAU - Ingerslev, Lars Roed AU - Ingerslev LR AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Manitta, Eleonora AU - Manitta E AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Dehestani, Yasmin AU - Dehestani Y AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Saupstad, Marte AU - Saupstad M AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Gonzalez-Franquesa, Alba AU - Gonzalez-Franquesa A AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Deshmukh, Atul Shahaji AU - Deshmukh AS AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Andersen, Emil AU - Andersen E AUID- ORCID: 0000-0001-6009-2099 AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. AD - ExSeed Health ApS, Copenhagen, Denmark. FAU - Barres, Romain AU - Barres R AUID- ORCID: 0000-0002-0158-519X AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. AD - Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, Inserm and Universite Cote d'Azur, Valbonne, France. LA - eng PT - Journal Article DEP - 20260911 PL - England TA - Hum Reprod Open JT - Human reproduction open JID - 101722764 PMC - PMC13682945 OTO - NOTNLM OT - ART OT - DNA methylation OT - bisulfite sequencing OT - epigenetics OT - spermatozoa EDAT- 2026/10/23 05:32 MHDA- 2026/10/23 05:33 PMCR- 2026/09/11 CRDT- 2026/10/23 01:13 PHST- 2025/11/17 00:00 [received] PHST- 2026/08/11 00:00 [revised] PHST- 2026/09/04 00:00 [accepted] PHST- 2026/10/23 05:33 [medline] PHST- 2026/10/23 05:32 [pubmed] PHST- 2026/10/23 01:13 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - hoag079 [pii] AID - 10.1093/hropen/hoag079 [doi] PST - epublish SO - Hum Reprod Open. 2026 Sep 11;2026(4):hoag079. doi: 10.1093/hropen/hoag079. eCollection 2026. PMID- 42908560 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261023 LR - 20261024 IS - 2633-4402 (Electronic) IS - 2633-4402 (Linking) VI - 6 DP - 2026 TI - Designing a context-specific intervention in practice: learning from a school-based physical activity intervention. PG - 78 LID - 10.3310/nihropenres.14336.2 [doi] LID - 78 AB - BACKGROUND: Public health interventions need to be designed for the intervention setting. Traditionally, to maximise internal validity, school-based pupil physical activity interventions deliver an identical programme across all settings. However, an interventions' success will depend on the context in which it is implemented, i.e. a schools' social, cultural, economic, environmental and other characteristics. In this paper we use the development of the PASSPORT (Physical Activity via a School-Specific PORTfolio) intervention as a case study for the development of context-specific public health interventions. We outline how we developed the intervention and draw out key learning from this for public health interventions generally. METHODS: The PASSPORT intervention takes a portfolio approach that allows schools to select and deliver tailored intervention content that is most suitable to their setting. The intervention was developed across multiple research steps that were designed to progressively build knowledge on school context and physical activity and integrate these into intervention design. We outline these in the paper. Formative studies include: a scoping review of intervention components; school staff interviews; a rapid ethnography; and a school survey. These findings informed the co-design of the intervention tool with primary school staff and the development of the portfolio content. Finally, we conducted a pilot study in two schools to learn from both the delivery of the intervention and associated evaluation data collection. KEY LEARNING: Key learning for context-specific intervention design has been gathered around four areas: Ground intervention design in a range of data and insight, Centre contextual experience, Design for intervention flexibility and user autonomy, and, Build in processes to test and iterate. CONCLUSIONS: Each of the formative studies and the intervention design steps provided parts of the complex picture of intervention context and design needs. Combined, the results of the studies supported the development of a context-specific intervention. CI - Copyright: (c) 2026 House D et al. FAU - House, Danielle AU - House D AUID- ORCID: 0000-0001-6171-9922 AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. FAU - Howard, Abi AU - Howard A AUID- ORCID: 0009-0005-0613-3028 AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. FAU - Kent-Saisch, Simona AU - Kent-Saisch S AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. FAU - Porter, Alice AU - Porter A AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. AD - NIHR Bristol Biomedical Research Centre, Bristol, England, UK. FAU - Reid, Tom AU - Reid T AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. FAU - Morbey, Roger AU - Morbey R AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. FAU - Emm-Collison, Lydia AU - Emm-Collison L AD - Centre for Exercise, Nutrition & Health Sciences, University of Bristol, Bristol, England, UK. FAU - de Vocht, Frank AU - de Vocht F AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. FAU - Salway, Ruth AU - Salway R AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. FAU - Jago, Russell AU - Jago R AUID- ORCID: 0000-0002-3394-0176 AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. AD - NIHR Bristol Biomedical Research Centre, Bristol, England, UK. LA - eng PT - Journal Article DEP - 20261008 PL - England TA - NIHR Open Res JT - NIHR open research JID - 9918333281906676 PMC - PMC13680835 OAB - WHAT THIS PAPER IS ABOUT: Programmes designed to support people's health need to be appropriate for the specific community they serve. For example, schools are a great place to support lots of children to be more active, but a programme needs to fit into the day-to-day life of a school for it to work well. Usually, health programmes are the same in each setting. But each setting is different, with different resources, people, equipment, and cultures. In this paper we describe how we designed a flexible programme that would be different in each school setting. We outline the steps we took to develop the programme and draw out key learning from this, to help other researchers who want to develop similar programmes. WHAT WE DID: We did several smaller projects to build up the information we needed to develop the flexible programme. These are described in the paper and include looking at current academic literature, doing interviews with school staff, spending lots of time in three schools, and doing a survey with many schools. We then took our learning from these projects to design the programme in workshops with school staff, and we used school knowledge and staff to develop the activities that make up the overall programme. We then tried out the intervention in two schools to learn from this. WHAT WE LEARNT: We learnt several key lessons that would be useful for other researchers who want to design a similar programme. 1) It was useful to have such a range of information to bring into the programme. 2) It was important to have the users, the people who would deliver the programme, at the centre of the programme development. 3) Designing the programme to be flexible was helpful, so that it could be different in each setting, and it was good for schools to be the decision-makers in this. 4) It was necessary to try out and improve the programme lots of times. OABL- eng OTO - NOTNLM OT - complex interventions OT - context OT - interventions OT - physical activity OT - public health OT - schools OT - settings COIS- No competing interests were disclosed. EDAT- 2026/10/23 05:32 MHDA- 2026/10/23 05:33 PMCR- 2026/10/08 CRDT- 2026/10/23 00:51 PHST- 2026/09/30 00:00 [accepted] PHST- 2026/10/23 05:33 [medline] PHST- 2026/10/23 05:32 [pubmed] PHST- 2026/10/23 00:51 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - 10.3310/nihropenres.14336.2 [doi] PST - epublish SO - NIHR Open Res. 2026 Oct 8;6:78. doi: 10.3310/nihropenres.14336.2. eCollection 2026. PMID- 42908542 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261024 IS - 1664-2295 (Electronic) IS - 1664-2295 (Linking) VI - 17 DP - 2026 TI - Psychiatric comorbidities in pediatric epilepsy: a single-center retrospective study highlighting the burden of depressive symptoms. PG - 1951989 LID - 10.3389/fneur.2026.1951989 [doi] LID - 1951989 AB - INTRODUCTION: Epilepsy in the pediatric population is frequently associated with psychiatric comorbidities. Depression is of particular clinical significance given its elevated incidence and substantial impact on quality of life, treatment adherence, and psychosocial functioning. The prevalence of depression in children with epilepsy ranges from 7% to 14%, considerably higher than the 1-5% reported in the general pediatric population. The relationship between epilepsy and depression appears bidirectional: epilepsy predisposes to depressive disorders, and depression may increase seizure risk, suggesting shared neurobiological pathways. This study aimed to assess the prevalence of psychiatric symptoms in pediatric patients with epilepsy, with particular focus on depressive symptomatology, and to examine associations with etiological and clinical variables. METHODS: This retrospective study included 240 pediatric patients (aged 2-18 years) diagnosed with epilepsy between 2013 and 2024. Psychiatric symptoms were ascertained retrospectively from clinical records. Patients were categorized into two groups: those with an identified genetic and/or structural abnormality (G1, n = 60) and those without (G2, n = 180). Statistical analysis employed the chi-squared test and Student's t-test (p < 0.05). RESULTS: Psychiatric symptoms were identified in 30% of patients (72/240, 95% CI 24.2-35.8%). The most prevalent disorder was attention-deficit/hyperactivity disorder (ADHD; n = 30), followed by sleep disturbance/asthenia (n = 19), aggression/temper tantrums (n = 13), depressive/mood symptoms (n = 11), anxiety symptoms (n = 10), autism spectrum disorder (n = 6), eating behavior alterations (n = 4), self-harm (n = 4), adjustment/self-esteem features (n = 3), obsessive-compulsive disorder (OCD; n = 3), panic attacks (n = 2), and suicide attempts (n = 2). Psychiatric symptoms were significantly more prevalent in G1 (42%, 95% CI 29.2-54.1%) than in G2 (26%, 95% CI 19.7-32.5%; p = 0.03), corresponding to an odds ratio of 2.02 (95% CI 1.10-3.72). No significant associations were found between psychiatric symptoms and age, sex, family history, or treatment regimen. DISCUSSION: Psychiatric comorbidities, including depressive symptomatology, are common in pediatric epilepsy and likely associated with underlying neurobiological factors. These findings support integrating neuropsychiatric screening, using validated instruments such as the Children's Depression Inventory-2 (CDI-2) and the Neurological Disorders Depression Inventory for Epilepsy-Youth version (NDDI-E-Y), into routine epilepsy care. CI - Copyright (c) 2026 De Leonardis, Spalice, Verrotti, De Rosa and Aloisio. FAU - De Leonardis, Arianna AU - De Leonardis A AD - Pediatric Neurology Unit, Department of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy. AD - Department of Pediatrics, University of Perugia, Perugia, Italy. FAU - Spalice, Alberto AU - Spalice A AD - Pediatric Neurology Unit, Department of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy. FAU - Verrotti, Alberto AU - Verrotti A AD - Department of Pediatrics, University of Perugia, Perugia, Italy. FAU - De Rosa, Isabella AU - De Rosa I AD - Pediatric Neurology Unit, Department of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy. FAU - Aloisio, Simone AU - Aloisio S AD - Pediatric Neurology Unit, Department of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy. LA - eng PT - Journal Article DEP - 20261007 PL - Switzerland TA - Front Neurol JT - Frontiers in neurology JID - 101546899 SB - IM MH - Humans MH - Child MH - Retrospective Studies MH - Female MH - *Epilepsy/epidemiology/psychology/complications MH - Male MH - Adolescent MH - Comorbidity MH - Child, Preschool MH - *Depression/epidemiology MH - Prevalence MH - Attention Deficit Disorder with Hyperactivity/epidemiology PMC - PMC13683009 OTO - NOTNLM OT - ADHD OT - depression OT - epilepsy OT - pediatrics OT - psychiatric comorbidity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors AS, AV declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/10/23 05:32 MHDA- 2026/10/23 05:33 PMCR- 2026/10/07 CRDT- 2026/10/23 00:36 PHST- 2026/07/29 00:00 [received] PHST- 2026/09/14 00:00 [revised] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/10/23 05:33 [medline] PHST- 2026/10/23 05:32 [pubmed] PHST- 2026/10/23 00:36 [entrez] PHST- 2026/10/07 00:00 [pmc-release] AID - 10.3389/fneur.2026.1951989 [doi] PST - epublish SO - Front Neurol. 2026 Oct 7;17:1951989. doi: 10.3389/fneur.2026.1951989. eCollection 2026. PMID- 42907746 OWN - NLM STAT- MEDLINE DCOM- 20261022 LR - 20261024 IS - 1471-2334 (Electronic) IS - 1471-2334 (Linking) VI - 26 IP - 1 DP - 2026 Jul 24 TI - Perceived fatalism regarding possible COVID-19 infection and its association with self-reported comorbidities in 12 Latin American countries. LID - 10.1186/s12879-026-14042-7 [doi] LID - 1852 AB - INTRODUCTION: The COVID-19 pandemic has had substantial mental health consequences worldwide. However, evidence on perceived fatalism regarding possible COVID-19 infection, particularly in relation to self-reported comorbidities, remains limited in Latin America. OBJECTIVE: To assess perceived fatalism regarding possible COVID-19 infection and its association with self-reported comorbidities among participants recruited in 12 Latin American countries. METHODS: This multicenter analytical cross-sectional study used a non-probability online snowball sampling strategy from June to August 2020. The study included 6,530 participants from Peru, Chile, Paraguay, Mexico, Colombia, Bolivia, Panama, Ecuador, Costa Rica, El Salvador, Honduras, and Guatemala. Perceived fatalism was assessed using five items from a previously developed COVID-19 fatalism scale. The five-item overall score was the primary measure, whereas domain-specific analyses were considered exploratory because of their lower reliability. Self-reported respiratory disease, cardiac disease, diabetes mellitus, obesity, and other illnesses were analyzed as exposure variables. Adjusted prevalence ratios (aPRs) and 95% confidence intervals (CIs) were estimated using generalized linear models from the Poisson family with log link and robust variance. RESULTS: The median age was 22 years (IQR: 19-28), 58.8% of participants were female, 25.3% reported at least one comorbidity, and 55.0% of the sample was recruited in Peru. The five-item fatalism scale showed acceptable internal consistency (Cronbach's alpha = 0.707; McDonald's omega/Raykov's rho = 0.721). In adjusted models, high overall fatalism was more prevalent among participants reporting respiratory disease (aPR 1.17, 95% CI 1.05-1.30), cardiac disease (aPR 1.25, 95% CI 1.08-1.44), diabetes mellitus (aPR 1.32, 95% CI 1.09-1.61), obesity (aPR 1.23, 95% CI 1.10-1.37), and other illnesses (aPR 1.26, 95% CI 1.15-1.39). Men had a lower prevalence of high overall fatalism (aPR 0.88, 95% CI 0.83-0.94). Sensitivity analyses yielded materially similar estimates. CONCLUSIONS: In this non-probabilistic sample from 12 Latin American countries, self-reported comorbidities were associated with a modestly higher prevalence of perceived fatalism regarding possible COVID-19 infection. These findings should be interpreted as exploratory and hypothesis-generating, given the cross-sectional design, self-reported exposures, potential residual confounding, and the young, Peru-predominant, non-probability sample. They should not be interpreted as nationally representative estimates or as evidence of causal relationships. CI - (c) 2026. The Author(s). FAU - Mejia, Christian R AU - Mejia CR AUID- ORCID: 0000-0002-5940-7281 AD - Universidad de Huanuco, Huanuco, Peru. FAU - Vega-Useche, Camilo AU - Vega-Useche C AUID- ORCID: 0000-0002-7064-1765 AD - Fundacion Santa Fe de Bogota, Bogota, Colombia. acamilovega@gmail.com. AD - Universidad Pedagogica y Tecnologica de Colombia, Tunja, Colombia. acamilovega@gmail.com. FAU - Serna-Alarcon, Victor AU - Serna-Alarcon V AUID- ORCID: 0000-0002-9803-6217 AD - Universidad Privada Antenor Orrego, Piura, Peru. AD - Hospital de la Amistad Peru Corea Santa Rosa II-2, Piura, Peru. FAU - Cedillo-Balcazar, Jamil AU - Cedillo-Balcazar J AUID- ORCID: 0000-0003-1468-0628 AD - Direccion Provincial de Salud de Loja, Ministerio de Salud Publica, Loja, Ecuador. FAU - Chamorro-Espinoza, Scherlli E AU - Chamorro-Espinoza SE AUID- ORCID: 0000-0003-1412-3872 AD - Asociacion Medica de Investigacion y Servicios en Salud, Lima, Peru. FAU - Yanez, Jaime A AU - Yanez JA AUID- ORCID: 0000-0002-9713-1829 AD - Escuela de Posgrado, Universidad Internacional Iberoamericana, Campeche, Mexico. FAU - Davies, Neal M AU - Davies NM AUID- ORCID: 0000-0002-7050-1471 AD - University of Alberta, Edmonton, Canada. FAU - Useche-Villamizar, Dalia AU - Useche-Villamizar D AUID- ORCID: 0000-0003-0594-023X AD - Universidad Pedagogica y Tecnologica de Colombia, Tunja, Colombia. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260724 PL - England TA - BMC Infect Dis JT - BMC infectious diseases JID - 100968551 SB - IM MH - Humans MH - Female MH - *COVID-19/psychology/epidemiology/mortality MH - Male MH - Latin America/epidemiology MH - Cross-Sectional Studies MH - Adult MH - Self Report MH - Comorbidity MH - Middle Aged MH - Young Adult MH - SARS-CoV-2 MH - Adolescent MH - Aged PMC - PMC13688888 OTO - NOTNLM OT - COVID-19 OT - Comorbidity OT - Cross-sectional study OT - Fatalism OT - Latin America OT - Mental health COIS- Declarations. Ethics approval: This study was approved by the Research Bioethics Committee of Universidad Privada Antenor Orrego (Resolution No. 0237-2020-UPAO) and was conducted in accordance with the principles of the Declaration of Helsinki. Informed consent: Informed consent was obtained electronically from all individual participants included in the study. Competing interests: The authors declare no competing interests. EDAT- 2026/10/22 23:29 MHDA- 2026/10/22 23:30 PMCR- 2026/07/24 CRDT- 2026/10/22 21:38 PHST- 2026/03/23 00:00 [received] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/10/22 23:30 [medline] PHST- 2026/10/22 23:29 [pubmed] PHST- 2026/10/22 21:38 [entrez] PHST- 2026/07/24 00:00 [pmc-release] AID - 10.1186/s12879-026-14042-7 [pii] AID - 14042 [pii] AID - 10.1186/s12879-026-14042-7 [doi] PST - epublish SO - BMC Infect Dis. 2026 Jul 24;26(1):1852. doi: 10.1186/s12879-026-14042-7. PMID- 42906500 OWN - NLM STAT- Publisher LR - 20261022 IS - 1873-6297 (Electronic) IS - 0001-6918 (Linking) VI - 270 DP - 2026 Oct 21 TI - Move or sit: Preschoolers' in-kindergarten physical activity and its association with fundamental motor skills using AI-assisted movement assessment. PG - 107976 LID - S0001-6918(26)01777-4 [pii] LID - 10.1016/j.actpsy.2026.107976 [doi] AB - This observational study examined physical activity (PA) across three kindergarten contexts and its association with fundamental motor skills (FMS), with a proprietary AI-assisted video/action-analysis tool used as a supplementary assessment aid. Fifty-seven children (61.11 +/- 12.73 months; range 45-81 months) from one kindergarten in Chengdu, China, were observed during morning exercise, organized physical education (PE), and free play using the Observational System for Recording Physical Activity in Children-Preschool Version (OSRAC-P); FMS were assessed with the standardized Fundamental Movement Skills Development Test for Children Aged 3-10 Years. The AI component was the proprietary "Xiaoneng Classmate" action-analysis platform developed by Chengdu Tixiaoneng Education Technology Co., Ltd.; manufacturer materials document AI-assisted action/video analysis and digital testing/data functions but do not disclose a public model architecture or study-specific validation metrics. Mean activity level was highest during morning exercise (3.29 +/- 0.09), followed by free play (2.94 +/- 0.40), and lowest during organized PE (2.46 +/- 0.26). Organized PE had the highest sedentary frequency (46.58% +/- 12.69%), whereas free play had the highest MVPA frequency (33.92% +/- 13.03%). To address multicollinearity in the original high-dimensional regression, parsimonious individual-level models adjusted for age, sex, and BMI and included MVPA during organized PE and free play. Organized-PE MVPA was positively associated with locomotor skill score (B = 0.471 per percentage point, HC3 SE = 0.141, beta = 0.407, 95% CI [0.187, 0.754], p = .002) and showed a weaker association with total FMS (B = 0.484, HC3 SE = 0.235, beta = 0.234, 95% CI [0.011, 0.957], p = .045); no PA predictor was significant for object-control or stability scores. Morning-exercise MVPA was not entered in the individual-level regression because it had no within-class variability. These findings are context-specific associations and do not establish causal direction. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Xu, Dongmiao AU - Xu D AD - School of Physical Education, Sichuan University, Chengdu, 610065, China. Electronic address: 2024227025001@stu.scu.edu.cn. FAU - Yang, Shunxiang AU - Yang S AD - Primary School Affillated to the Experimental High School of UESTC, Chengdu, 611730, China. Electronic address: shunxiangyang@163.com. FAU - Liu, Liu AU - Liu L AD - School of Physical Education, Sichuan University, Chengdu, 610065, China; School of Modern Service in Mianyang City College, Mianyang, 621000, China. Electronic address: liu_liu@scu.edu.cn. FAU - Gou, Jingpu AU - Gou J AD - College of Sports Training in Chengdu Sport University, Chengdu, 610041, China. Electronic address: guojingpu@sina.com. FAU - Zeng, Hongguang AU - Zeng H AD - School of Physical Education, Sichuan University, Chengdu, 610065, China. Electronic address: 570959086@qq.com. FAU - Liu, Liling AU - Liu L AD - School of Physical Education, Sichuan University, Chengdu, 610065, China. Electronic address: lilingliu0209@163.com. FAU - Zhu, Liangyu AU - Zhu L AD - School of Physical Education, Sichuan University, Chengdu, 610065, China. Electronic address: zly0621@scu.edu.cn. LA - eng PT - Journal Article DEP - 20261021 PL - Netherlands TA - Acta Psychol (Amst) JT - Acta psychologica JID - 0370366 SB - IM OTO - NOTNLM OT - AI-assisted movement assessment OT - Fundamental motor skills OT - OSRAC-P OT - Physical activity OT - Preschool children COIS- Declaration of competing interest The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/10/22 23:29 MHDA- 2026/10/22 23:29 CRDT- 2026/10/22 19:40 PHST- 2026/07/09 00:00 [received] PHST- 2026/09/16 00:00 [revised] PHST- 2026/10/07 00:00 [accepted] PHST- 2026/10/22 23:29 [medline] PHST- 2026/10/22 23:29 [pubmed] PHST- 2026/10/22 19:40 [entrez] AID - S0001-6918(26)01777-4 [pii] AID - 10.1016/j.actpsy.2026.107976 [doi] PST - aheadofprint SO - Acta Psychol (Amst). 2026 Oct 21;270:107976. doi: 10.1016/j.actpsy.2026.107976. PMID- 42902300 OWN - NLM STAT- MEDLINE DCOM- 20261021 LR - 20261023 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 23 TI - Retrospective cross-sectional study of clinical and laboratory profiles of paediatric tuberculosis at Ayder Comprehensive Specialized Hospital, Ethiopia (2018-2021). LID - 10.1186/s12887-026-07391-4 [doi] LID - 1029 AB - BACKGROUND: Pediatric Tuberculosis (TB) remains a diagnostic challenge owing to its paucibacillary nature and diverse clinical presentation. We aimed to characterise the clinical pattern, diagnostic yields, and predictors of disease forms among children managed at Ayder Comprehensive Specialized Hospital (ACSH), Mekelle, Ethiopia. OBJECTIVE: To describe the disease form distribution, clinical features, and laboratory profiles of pediatric tuberculosis at a tertiary Ethiopian hospital, and to identify independent predictors of extrapulmonary and disseminated disease using multivariable logistic regression. METHODS: We conducted an institution-based, retrospective analytical cross-sectional study of 123 children (< 18) diagnosed with TB at ACSH between May 2018 and April 2021. From 180 screened charts, we excluded 57 cases (prior treatment n = 27, incomplete records n = 20, insufficient evidence n = 10). Using validated data extraction checklist, we analysed sociodemographics, clinical presentation, nutritional status, comorbidities, laboratory results (GeneXpert, ESR, haemoglobin), and TB disease forms via SPSS version 23, applying bivariable and multivariable logistic regression. RESULTS: The mean age was 8.8 +/- 5.3 years; adolescents (11-17 years) comprised 42.3% (n = 52). Females were slightly predominant (52%). Common presenting symptoms included fever (78%), weight loss (71.5%), and cough (55.5%). Severe acute malnutrition (SAM) affected 37.7% (n = 40/106), with the highest burden in children aged < 5 years (45.7%). Anaemia was prevalent in 62.7% (n = 74/118); ESR was elevated in 84% (n = 89/106). Extrapulmonary TB (EPTB) was the most common form (43.9%; 95% CI 35.2-52.9). GeneXpert positivity was 31.3%. Younger age was significantly associated with EPTB (p < 0.001); children aged 0-4 years had over 3.5 times higher odds of EPTB compared with adolescents (AOR 3.57; 95% CI 1.28-10.00; p = 0.015). CONCLUSION: Paediatric TB in this referral setting is characterised by high rates of extrapulmonary and disseminated disease, severe malnutrition, and low bacteriological confirmation. Younger age was independently associated with disease dissemination, a finding consistent with the immunological characteristics of early childhood. Early, age-stratified screening and adoption of more sensitive diagnostic tools are urgently needed in similar high-burden settings. CI - (c) 2026. The Author(s). FAU - Girmay, Tekae Gebru AU - Girmay TG AD - Department of Pediatrics and Child health, School of Medicine, College of Medicine and health science, Mekelle University, Mekelle, Ethiopia. FAU - Gossaye, Tariku Yigremachew AU - Gossaye TY AUID- ORCID: 0009-0001-8137-1908 AD - Department of Pediatrics and Child health, College of Medicine and Health Science, Mizan Tepi University, Mizan Aman, Ethiopia. Tarikuyigremachew@gmail.com. FAU - Gebrihiet, Haftu Hailu AU - Gebrihiet HH AD - Department of Pediatrics and Child health, College of Medicine and Health science, Mekelle University, Mekelle, Ethiopia. FAU - Tsegay, Niguse AU - Tsegay N AD - Department of Pediatrics and Child health, College of Medicine and Health science, Mekelle University, Mekelle, Ethiopia. LA - eng PT - Journal Article DEP - 20260723 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Female MH - Ethiopia/epidemiology MH - Cross-Sectional Studies MH - Child MH - Male MH - Retrospective Studies MH - Adolescent MH - Tuberculosis, Extrapulmonary MH - *Tuberculosis/diagnosis/epidemiology MH - Child, Preschool MH - Infant PMC - PMC13685323 OTO - NOTNLM OT - Clinical profile OT - Diagnostic challenges OT - Ethiopia OT - Extrapulmonary TB OT - Paediatric tuberculosis COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance the declaration of Helsinki. Ethical approval was obtained from Institutional Review Board (IRB) of the College of Health Sciences of Mekelle University (Reference No: MU-IRB/1864/21). Permission from Ayder Comprehensive Specialized Hospital clinical director offices, support letter from chief clinical director obtained before the commencement of the study. Because this was retrospective chart review involving minimal risk to the participants, the requirement for informed consent from the parents or legal guardian of minors was formally waived by Mekelle University IRB. All patients' data were handled with strict confidentiality and were anonymized prior to Analysis. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/21 05:32 MHDA- 2026/10/21 05:33 PMCR- 2026/07/23 CRDT- 2026/10/21 00:43 PHST- 2026/03/16 00:00 [received] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/10/21 05:33 [medline] PHST- 2026/10/21 05:32 [pubmed] PHST- 2026/10/21 00:43 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - 10.1186/s12887-026-07391-4 [pii] AID - 7391 [pii] AID - 10.1186/s12887-026-07391-4 [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 23;26(1):1029. doi: 10.1186/s12887-026-07391-4. PMID- 42898497 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261020 LR - 20261022 IS - 2667-3681 (Electronic) IS - 2667-3681 (Linking) VI - 20 DP - 2026 Dec TI - Content validation of the Eating Behavior and Appetite Questionnaire (EBAQ) in adolescents with obesity or overweight. PG - 100342 LID - 10.1016/j.obpill.2026.100342 [doi] LID - 100342 AB - BACKGROUND: Obesity in children and adolescents is a growing global concern. Changes in appetite and eating behaviors are clinically relevant outcomes for long-term management of obesity. The Eating Behavior and Appetite Questionnaire (EBAQ) was developed as existing patient-reported outcome measures do not comprehensively capture concepts important to individuals with obesity. Its content and psychometric validity have been demonstrated in adults; this study evaluated the content validity of the 17-item EBAQ in adolescents with obesity or overweight. METHODS: This cross-sectional qualitative study included US-based adolescents (12-17 years) with obesity or with overweight and >/=1 obesity-related complication. Cognitive interviews were conducted via telephone/teleconference using a semi-structured interview guide. Participants completed the EBAQ and provided feedback on its relevance, clarity, and comprehensiveness. Transcripts were coded using a coding framework. RESULTS: Fifteen adolescents (mean age, 14.7 years; mean body-mass index, 33.6 kg/m(2)) participated. Most (12/15, 80%) had not received obesity management medications (OMMs). All (15/15, 100%) understood the instructions and recall period, and 14/15 (93%) understood the response options. Each item was understood by >/= 80% of the participants (>/=12/15), except for Item 5 ('Appetite was controlled'). Item 5 was understood by all participants who had received OMMs (n = 3) but only a few of the treatment-naive participants (n = 4), suggesting more relevance for those on treatment. Each item was deemed relevant by >/= 54% of the participants (>/=7/15), except Item 17 ('Eating because stressed') which was considered relevant by 46% (6/13) of the participants. Overall, most participants (11/15, 73%) found the EBAQ well-structured, easy to understand and complete, and relevant. CONCLUSION: Findings support the conceptual relevance, clarity, and appropriateness of the 17-item EBAQ for adolescents with obesity or overweight. The EBAQ may be used to assess appetite and eating behavior outcomes in adolescents with obesity or overweight in clinical trials and observational studies. CI - (c) 2026 The Authors. FAU - Kanu, Chisom AU - Kanu C AD - Eli Lilly and Company, Indianapolis, IN, USA. FAU - Clucas, Claudine AU - Clucas C AD - Patient-Centered Research, Evidera, PPD Clinical Research Business of Thermo Fisher Scientific, London, UK. FAU - Gibble, Theresa Hunter AU - Gibble TH AD - Eli Lilly and Company, Indianapolis, IN, USA. FAU - Samuelson, Ashley AU - Samuelson A AD - Patient-Centered Research, Evidera, PPD Clinical Research Business of Thermo Fisher Scientific, Wilmington, NC, USA. FAU - Karn, Hayley AU - Karn H AD - Patient-Centered Research, Evidera, PPD Clinical Research Business of Thermo Fisher Scientific, London, UK. LA - eng PT - Journal Article DEP - 20261007 PL - United States TA - Obes Pillars JT - Obesity pillars JID - 9918697364706676 PMC - PMC13678099 OTO - NOTNLM OT - Adolescents OT - Appetite OT - Content validation OT - Eating behavior OT - Obesity OT - Patient-reported outcomes COIS- CK and THG are employees and shareholders of Eli Lilly and Company, which funded this study. CC, AS, and HK are current employees of Evidera, which was paid by Eli Lilly and Company to conduct this study. The Eating Behavior and Appetite Questionnaire (EBAQ) is copyrighted by Eli Lilly and Company and is free for use once permission is obtained. For permission to reproduce or use the EBAQ, contact copyright@lilly.com. EDAT- 2026/10/20 11:33 MHDA- 2026/10/20 11:34 PMCR- 2026/10/07 CRDT- 2026/10/20 08:46 PHST- 2026/07/23 00:00 [received] PHST- 2026/10/06 00:00 [revised] PHST- 2026/10/06 00:00 [accepted] PHST- 2026/10/20 11:34 [medline] PHST- 2026/10/20 11:33 [pubmed] PHST- 2026/10/20 08:46 [entrez] PHST- 2026/10/07 00:00 [pmc-release] AID - S2667-3681(26)00098-7 [pii] AID - 100342 [pii] AID - 10.1016/j.obpill.2026.100342 [doi] PST - epublish SO - Obes Pillars. 2026 Oct 7;20:100342. doi: 10.1016/j.obpill.2026.100342. eCollection 2026 Dec. PMID- 42896171 OWN - NLM STAT- MEDLINE DCOM- 20261019 LR - 20261019 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 Oct 19 TI - Tuberculosis Among Artisanal Miners in the Mulongo Health Zone, Democratic Republic of Congo: Unmatched Case-Control Study. PG - e93635 LID - 10.2196/93635 [doi] AB - BACKGROUND: Tuberculosis (TB) remains a major global health challenge, with 10.6 million new cases and 1.3 million deaths reported in 2022. Artisanal miners in sub‑Saharan Africa are particularly vulnerable due to poverty, overcrowded living conditions, and high HIV prevalence. In the Democratic Republic of Congo (DRC), TB prevalence among miners is high, yet determinants remain insufficiently studied. OBJECTIVE: This study aimed to identify sociodemographic, behavioral, and clinical factors associated with TB among artisanal miners in the Mulongo health zone, Haut‑Lomami Province, DRC. METHODS: We conducted an unmatched case-control study among miners aged >/=15 years. Data were collected using a validated questionnaire covering socioeconomic, behavioral, and biomedical variables. Interviewers were blinded to TB status to minimize bias. Determinants were assessed using bivariate and multivariable logistic regression. RESULTS: Poverty was strongly associated with TB (adjusted odds ratio [aOR] 3.16, 95% CI 1.95-5.11; P<.001). Primary education was associated with increased TB risk (aOR 2.78, 95% CI 1.04-7.44; P=.04), while secondary education showed a borderline association (aOR 2.53, 95% CI 0.93-6.89; P=.07). Higher education was protective (aOR 0.62, 95% CI 0.40-0.95; P=.03). Poor knowledge of TB transmission (aOR 2.11, 95% CI 1.16-3.83; P=.02), cause (aOR 1.79, 95% CI 1.00-3.20; P=.049), and diagnosis (aOR 2.49, 95% CI 1.48-4.17; P=.001) were consistently linked to higher vulnerability. HIV infection was significantly associated with TB (aOR 4.65, 95% CI 1.00-21.74; P=.049). Overcrowding was more frequent among TB cases, but in adjusted models, the association was borderline (aOR 1.65, 95% CI 0.95-2.85; P=.07). Tobacco use (aOR 1.47, 95% CI 0.83-2.61; P=.18), alcohol consumption (aOR 1.18, 95% CI 0.70-1.98; P=.54), and nutritional status (aOR 1.36, 95% CI 0.78-2.37; P=.28) were not significantly associated with TB. CONCLUSIONS: TB among artisanal miners appears to be driven primarily by poverty, limited education, poor knowledge, and HIV infection. Overcrowding showed a suggestive but nonsignificant association. Integrated interventions should prioritize poverty alleviation, improved housing, tailored health education, and strengthened TB and HIV services, while further studies are needed to clarify the role of overcrowding and other contextual factors. CI - (c)Josue Mutangala Muloye, Fiston Ilunga Mbayo, Jacques Muteba Kakoma, Francois Kitobo Mashika, Jean Claude Banze Kabwe Ilunga, Pacifique Kanku Wa Ilunga, Gloire Kasongo Lupitshi, Didy Lwamba Kabiya, Paulin Beya Wa Bitadi Mutombo. Originally published in JMIR Formative Research (https://formative.jmir.org), 19.10.2026. FAU - Mutangala Muloye, Josue AU - Mutangala Muloye J AUID- ORCID: 0009-0006-4941-1558 AD - Health Zone of Lwamba, Lwamba, Haut Lomami, The Democratic Republic of The Congo. FAU - Ilunga Mbayo, Fiston AU - Ilunga Mbayo F AUID- ORCID: 0009-0004-0354-721X AD - School of Public Health, University of Malemba Nkulu, Malemba Nkulu, Haut Lomami, The Democratic Republic of The Congo. AD - General Reference Hospital of Malemba Nkulu, Malemba Nkulu, Haut Lomami, The Democratic Republic of The Congo. FAU - Muteba Kakoma, Jacques AU - Muteba Kakoma J AUID- ORCID: 0009-0001-4910-2185 AD - University of Kamina, Kamina, Haut-Lomami, The Democratic Republic of The Congo. FAU - Kitobo Mashika, Francois AU - Kitobo Mashika F AUID- ORCID: 0009-0002-4622-0052 AD - Provincial Health Division of Haut-Lomami, Kamina, Haut Lomami, The Democratic Republic of The Congo. FAU - Banze Kabwe Ilunga, Jean Claude AU - Banze Kabwe Ilunga JC AUID- ORCID: 0009-0005-9882-4933 AD - University of Kamina, Kamina, Haut-Lomami, The Democratic Republic of The Congo. FAU - Kanku Wa Ilunga, Pacifique AU - Kanku Wa Ilunga P AUID- ORCID: 0009-0005-4738-2549 AD - University of Kamina, Kamina, Haut-Lomami, The Democratic Republic of The Congo. FAU - Kasongo Lupitshi, Gloire AU - Kasongo Lupitshi G AUID- ORCID: 0009-0005-4731-9750 AD - School of Public Health, University of Malemba Nkulu, Malemba Nkulu, Haut Lomami, The Democratic Republic of The Congo. FAU - Lwamba Kabiya, Didy AU - Lwamba Kabiya D AUID- ORCID: 0009-0002-5529-3456 AD - Higher Institute of Medical Techniques of Kamina, Kamina, Haut Lomami, The Democratic Republic of The Congo. FAU - Mutombo, Paulin Beya Wa Bitadi AU - Mutombo PBWB AUID- ORCID: 0000-0003-4663-9419 AD - School of Public Health, Medicine, University of Kinshasa, Kinshasa, Kinshasa, The Democratic Republic of The Congo. LA - eng PT - Journal Article DEP - 20261019 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - Democratic Republic of the Congo/epidemiology MH - Male MH - Case-Control Studies MH - Adult MH - *Tuberculosis/epidemiology MH - *Miners/statistics & numerical data MH - Middle Aged MH - Female MH - Prevalence MH - Surveys and Questionnaires MH - Risk Factors MH - Adolescent MH - Young Adult MH - Poverty MH - HIV Infections/epidemiology OTO - NOTNLM OT - Democratic Republic of Congo OT - HIV OT - artisanal miners OT - case-control study OT - overcrowding OT - poverty OT - tuberculosis EDAT- 2026/10/19 17:31 MHDA- 2026/10/19 23:30 CRDT- 2026/10/19 16:53 PHST- 2026/02/16 00:00 [received] PHST- 2026/07/15 00:00 [accepted] PHST- 2026/07/14 00:00 [revised] PHST- 2026/10/19 23:30 [medline] PHST- 2026/10/19 17:31 [pubmed] PHST- 2026/10/19 16:53 [entrez] AID - v10i1e93635 [pii] AID - 10.2196/93635 [doi] PST - epublish SO - JMIR Form Res. 2026 Oct 19;10:e93635. doi: 10.2196/93635. PMID- 42896087 OWN - NLM STAT- MEDLINE DCOM- 20261019 LR - 20261022 IS - 1460-2083 (Electronic) IS - 0964-6906 (Print) IS - 0964-6906 (Linking) VI - 35 IP - 21 DP - 2026 Oct 13 TI - The monogenic forms of obesity in Saudi families. LID - 10.1093/hmg/ddag054 [doi] LID - ddag054 AB - BACKGROUND: Obesity is a multifactorial disorder with a substantial yet incompletely defined genetic component. Rare monogenic variants, particularly in consanguineous populations, may account for part of the 'missing heritability.' OBJECTIVES: To delineate the genetic contribution to severe obesity in individuals from Saudi Arabia by pinpointing known and novel monogenic variants in families presenting with extreme phenotypes. METHODS: Eight multiplex Saudi families (each comprising 9 members; range: lean body weight to severe obesity) were enrolled. Adults had a BMI of >/=30 kg/m2; children exceeded the 90th percentile (overweight) or the 97th percentile (obese). Whole-exome sequencing (WES) was performed on samples collected from two children in each family, including one child with obesity and one control child without obesity. Variant calling files were filtered for quality, frequency < 1%, and predicted functional impact. Candidate loci were prioritized using Moon (Diploid) software and manual curation, then validated by Sanger sequencing. RESULTS: Initial filtering revealed 40 rare, potentially pathogenic variants in 35 genes shared among affected relatives. Prioritization highlighted 28 variants in 19 candidate genes, encompassing established obesity-related genes (e.g. LEPR, MC4R, BDNF) and putative novel loci linked to appetite regulation, lipid metabolism, and energy balance. Segregation analysis identified both heterozygous and homozygous variants across affected individuals, reflecting variability in inheritance patterns. Seven previously reported candidate genes did not show pathogenic variants in this cohort. Carriers of prioritized variants exhibited significantly higher BMI z-scores than non-carriers (P < 0.01), underscoring a clear genotype-phenotype correlation. CONCLUSION: This study broadens the catalog of genes associated with obesity in the Saudi population and demonstrates the value of studying extreme phenotypes in consanguineous families. Both previously recognized and novel variants were identified in association with severe, early-onset obesity, reflecting genetic heterogeneity across families rather than a single underlying mechanism. These findings provide a foundation for improved genetic characterization, tailored counseling, and future functional studies. CI - (c) The Author(s) 2026. Published by Oxford University Press. FAU - Almolafikh, Sultanah Turki AU - Almolafikh ST AD - Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University,, P.O. Box 2460, Riyadh 11451, Saudi Arabia. FAU - Alshatwi, Ali A AU - Alshatwi AA AD - Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University,, P.O. Box 2460, Riyadh 11451, Saudi Arabia. FAU - Orfali, Razan AU - Orfali R AUID- ORCID: 0000-0002-0584-4013 AD - Department of Pharmacology, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317, Saudi Arabia. FAU - AlSaud, Haya AU - AlSaud H AD - King Faisal Specialist Hospital Research Centre, Riyadh, 13458, Saudi Arabia. AD - King Abdulaziz City for Science and Technology, Riyadh 12354, Saudi Arabia. AD - Hevolution Foundation, King Saud University, Riyadh 13519, Saudi Arabia. LA - eng GR - Research Center in King Faisal Specialist Hospital in Riyadh/ PT - Journal Article PL - England TA - Hum Mol Genet JT - Human molecular genetics JID - 9208958 RN - 0 (Receptors, Leptin) RN - 0 (Receptor, Melanocortin, Type 4) RN - 0 (LEPR protein, human) RN - 0 (MC4R protein, human) SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Pedigree MH - Female MH - *Obesity/genetics/pathology/epidemiology MH - Male MH - Child MH - *Genetic Predisposition to Disease MH - Adult MH - Receptors, Leptin/genetics MH - Exome Sequencing MH - Phenotype MH - Consanguinity MH - Receptor, Melanocortin, Type 4/genetics MH - Body Mass Index MH - Adolescent PMC - PMC13679745 OTO - NOTNLM OT - consanguineous families OT - heterozygosity OT - homozygosity OT - monogenic OT - obesity OT - rare disease OT - syndromic of obesity COIS- The authors declare no conflict of interest. EDAT- 2026/10/19 17:31 MHDA- 2026/10/19 17:32 PMCR- 2026/10/19 CRDT- 2026/10/19 15:24 PHST- 2025/10/17 00:00 [received] PHST- 2026/05/08 00:00 [revised] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/10/19 17:32 [medline] PHST- 2026/10/19 17:31 [pubmed] PHST- 2026/10/19 15:24 [entrez] PHST- 2026/10/19 00:00 [pmc-release] AID - 8943647 [pii] AID - ddag054 [pii] AID - 10.1093/hmg/ddag054 [doi] PST - ppublish SO - Hum Mol Genet. 2026 Oct 13;35(21):ddag054. doi: 10.1093/hmg/ddag054. PMID- 42895271 OWN - NLM STAT- MEDLINE DCOM- 20261019 LR - 20261022 IS - 2047-2986 (Electronic) IS - 2047-2978 (Print) IS - 2047-2978 (Linking) VI - 16 DP - 2026 Oct 19 TI - External validation and application of machine learning models for obesity in Chinese children and adolescents per Chinese and WHO growth standards. PG - 04299 LID - 10.7189/jogh.16.04299 [doi] LID - 04299 AB - BACKGROUND: Childhood and adolescent obesity is a growing global public health challenge, underscoring the need for reliable tools to identify individuals at high risk. We aimed to develop, validate, and deploy machine learning (ML) models for predicting obesity in children and adolescents aged 3-18 years using multi-domain risk factors per Chinese and World Health Organization (WHO) growth standards, with an online tool for clinical and public health translation. METHODS: We conducted a population-based cross-sectional study. We used data from 22,555 participants in Beijing (2022, 2024) for training/internal validation, and data from 5,343 participants in Tangshan (2020) for external validation. We defined obesity using both Chinese and WHO growth standards. We analysed 38 features across 5 domains; we selected key predictors using least absolute shrinkage and selection operator regression. We evaluated 4 ML models using 28 performance metrics, with SHapley Additive exPlanations enhancing interpretability. RESULTS: We retained 5 features per the Chinese growth standards and 12 per the WHO growth standards. Age, maternal body mass index (BMI), paternal BMI, screen time, and birthweight were consistent predictors. The neural network achieved optimal performance per Chinese growth standards (area under the receiver operating characteristic curve (AUROC) = 0.735), and eXtreme gradient boosting performed best per WHO growth standards (AUROC = 0.736), with the corresponding external validation AUROCs of 0.699 and 0.707. We subsequently deployed user-friendly online prediction tools for translation. CONCLUSIONS: We identified two interpretable ML models for obesity in children and adolescents per both Chinese and WHO growth standards, each demonstrating modest but reliable predictive performance. CI - (c) 2026 The Authors. FAU - Zheng, Fangjieyi AU - Zheng F AD - Center for Evidence-based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Wang, Xiaoqian AU - Wang X AD - Center for Evidence-based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. AD - Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Xue, Mei AU - Xue M AD - Graduate School, Beijing University of Chinese Medicine, Beijing, China. AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China. FAU - Wang, Qiong AU - Wang Q AD - Graduate School, Beijing University of Chinese Medicine, Beijing, China. AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China. FAU - Zhang, Wenqian AU - Zhang W AD - Center for Evidence-based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Zhang, Zhixin AU - Zhang Z AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China. AD - Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China. FAU - Niu, Wenquan AU - Niu W AD - Center for Evidence-based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20261019 PL - Scotland TA - J Glob Health JT - Journal of global health JID - 101578780 RN - Chinese people SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Male MH - Body Mass Index MH - China/epidemiology MH - Cross-Sectional Studies MH - *Machine Learning MH - *Pediatric Obesity/epidemiology MH - Predictive Learning Models MH - Risk Factors MH - World Health Organization MH - East Asian People PMC - PMC13679347 OTO - NOTNLM OT - Chinese and WHO growth standards OT - children and adolescents OT - external validation OT - machine learning OT - obesity COIS- Disclosure of interest: The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests. EDAT- 2026/10/19 11:36 MHDA- 2026/10/19 11:37 PMCR- 2026/10/19 CRDT- 2026/10/19 08:35 PHST- 2026/10/19 11:37 [medline] PHST- 2026/10/19 11:36 [pubmed] PHST- 2026/10/19 08:35 [entrez] PHST- 2026/10/19 00:00 [pmc-release] AID - jogh-16-04299 [pii] AID - 10.7189/jogh.16.04299 [doi] PST - epublish SO - J Glob Health. 2026 Oct 19;16:04299. doi: 10.7189/jogh.16.04299. PMID- 42895101 OWN - NLM STAT- Publisher LR - 20261019 IS - 1619-3997 (Electronic) IS - 0300-5577 (Linking) DP - 2026 Oct 20 TI - Biochemical and anthropometric assessment of nutritional status at discharge in very-low-birth-weight infants: a retrospective cohort study. LID - 10.1515/jpm-2026-0439 [doi] AB - OBJECTIVES: To evaluate nutritional status at discharge in VLBW infants using biochemical and composite nutritional indices, and to examine their relationship with extrauterine growth restriction (EUGR; also termed "growth faltering" in more recent literature). METHODS: This retrospective cohort study included 124 very low birth weight infants (1). RESULTS: EUGR occurred in 43.5 % (cross-sectional) and 38.7 % (longitudinal) of infants. Hypouremia (18.0 %) and hypocreatininemia (12.0 %) were the most frequent abnormalities. Composite outcomes were associated with lower gestational age and small-for-gestational-age status. Cross-sectional EUGR was nominally associated with CNDO (aOR 3.72, p=0.023) and CMPDO (aOR 3.96, p=0.031) but not CPDO; given testing across four correlated composite outcomes without formal correction for multiple comparisons, these associations should be regarded as nominal. AUCs for the four composites ranged narrowly from 0.761 to 0.794 and were not formally compared. Anthropometric differences were not significant. CONCLUSIONS: Subclinical biochemical deficiency was common at discharge despite non-significant anthropometric differences. Composite biochemical indices showed similar, moderate discriminative performance across definitions; findings are hypothesis-generating and require external, prospective validation before any composite can be considered superior or used clinically. CI - (c) 2026 the author(s), published by De Gruyter, Berlin/Boston. FAU - Yaprak, Deniz AU - Yaprak D AUID- ORCID: 0000-0002-8130-7877 AD - Department of Pediatrics, Division of Neonatology, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkiye. FAU - Saygili Karagol, Belma AU - Saygili Karagol B AUID- ORCID: 0000-0003-3728-9613 AD - Department of Pediatrics, Division of Neonatology, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20261020 PL - Germany TA - J Perinat Med JT - Journal of perinatal medicine JID - 0361031 SB - IM OTO - NOTNLM OT - biochemical markers OT - composite outcomes OT - extrauterine growth restriction OT - malnutrition OT - neonatal nutrition OT - very low birth weight EDAT- 2026/10/19 11:36 MHDA- 2026/10/19 11:36 CRDT- 2026/10/19 06:04 PHST- 2026/07/25 00:00 [received] PHST- 2026/10/02 00:00 [accepted] PHST- 2026/10/19 11:36 [medline] PHST- 2026/10/19 11:36 [pubmed] PHST- 2026/10/19 06:04 [entrez] AID - jpm-2026-0439 [pii] AID - 10.1515/jpm-2026-0439 [doi] PST - aheadofprint SO - J Perinat Med. 2026 Oct 20. doi: 10.1515/jpm-2026-0439. PMID- 42893551 OWN - NLM STAT- Publisher LR - 20261018 IS - 1475-357X (Print) IS - 1475-357X (Linking) DP - 2026 Oct 18 TI - Longitudinal associations between dietary intake and common mental disorders among adolescents in Australia. LID - 10.1111/camh.70129 [doi] AB - BACKGROUND: There is a need for more longitudinal research exploring temporal associations between diet quality and common mental disorders (CMDs) during adolescence. This study examined prospective associations between indicators of adolescents' diet quality (fruit, vegetable, sugar-sweetened beverage [SSB] intakes) and risk of depression and anxiety onset over 3 years. We hypothesised that higher fruit and vegetable intake, and lower SSB intake, would be associated with lower risk of CMDs. METHODS: 6537 Australian adolescents (mean age 12.65 years at baseline) completed surveys at baseline, 1-, 2- and 3-year follow-ups. We fitted Generalised Estimating Equations Poisson regression models to assess longitudinal associations between daily servings of fruit, vegetables and SSBs, and risk of depression and anxiety onset (binary cut-points on validated scales) over 3 years. Models were re-run for males and females. Analyses excluded participants who met thresholds for depression or anxiety at baseline to increase confidence that diet predicted CMD onset. RESULTS: Higher fruit intake was associated with lower risk of depression (adjusted RR: 0.87, 95% CI: 0.82-0.93) and anxiety (adjusted RR: 0.93, 95% CI: 0.87-0.99) over 3 years, with limited evidence of sex differences. Higher SSB intake (log-transformed) was associated with higher CMD risk for both sexes, but more strongly for males (depression: adjusted RR: 3.25, 95% CI: 2.02-5.23; anxiety: adjusted RR: 5.50, 95% CI: 3.39-8.90) than females (depression: adjusted RR: 3.10, 95% CI: 2.06-4.68; anxiety: adjusted RR: 2.04, 95% CI: 1.23-3.37). Results inform the Global burden of disease Lifestyle And mental Disorders project (DERR2-https://doi.org/10.2196/65576). CONCLUSIONS: Longitudinal research exposing temporal associations between diet and CMDs may inform prevention/intervention efforts targeting modifiable risk factors for CMDs. CI - (c) 2026 The Author(s). Child and Adolescent Mental Health published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health. FAU - Davidson, Lily AU - Davidson L AUID- ORCID: 0000-0002-2811-0856 AD - The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia. FAU - Ashtree, Deborah N AU - Ashtree DN AUID- ORCID: 0000-0003-3680-3860 AD - Deakin University, IMPACT - The Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, Geelong, Vic., Australia. FAU - Osman, Bridie AU - Osman B AD - The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia. FAU - Smout, Scarlett AU - Smout S AD - The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia. FAU - Newton, Nicola C AU - Newton NC AD - The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia. FAU - Gardner, Lauren A AU - Gardner LA AD - The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia. FAU - O'Neil, Adrienne AU - O'Neil A AD - Deakin University, IMPACT - The Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, Geelong, Vic., Australia. FAU - Jacka, Felice AU - Jacka F AD - Deakin University, IMPACT - The Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, Geelong, Vic., Australia. AD - Centre for Adolescent Health, Murdoch Children's Research Institute, Melbourne, Vic., Australia. AD - College of Public Health, Medical & Veterinary Sciences, James Cook University, Townsville, Qld, Australia. FAU - Orr, Rebecca AU - Orr R AUID- ORCID: 0000-0002-2422-5533 AD - Deakin University, IMPACT - The Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, Geelong, Vic., Australia. FAU - Lane, Melissa AU - Lane M AD - Deakin University, IMPACT - The Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, Geelong, Vic., Australia. FAU - Teesson, Maree AU - Teesson M AD - The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia. FAU - Champion, Katrina E AU - Champion KE AD - The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia. AD - School of Public Health, The University of Sydney, Sydney, NSW, Australia. LA - eng GR - APP11349009/Centre of Research Excellence in Prevention and Early Intervention of Mental Illness and Substance Use/ GR - APP1078407/Australian National Health and Medical Research Council/ GR - APP1120641/Australian National Health and Medical Research Council/ GR - APP1166377/Australian National Health and Medical Research Council/ GR - Paul Ramsay Foundation/ PT - Journal Article DEP - 20261018 PL - England TA - Child Adolesc Ment Health JT - Child and adolescent mental health JID - 101142157 SB - IM OTO - NOTNLM OT - Adolescent OT - anxiety OT - depression OT - diet OT - mental disorder OT - prospective studies EDAT- 2026/10/18 17:32 MHDA- 2026/10/18 17:32 CRDT- 2026/10/18 15:03 PHST- 2026/09/03 00:00 [accepted] PHST- 2026/10/18 17:32 [medline] PHST- 2026/10/18 17:32 [pubmed] PHST- 2026/10/18 15:03 [entrez] AID - 10.1111/camh.70129 [doi] PST - aheadofprint SO - Child Adolesc Ment Health. 2026 Oct 18. doi: 10.1111/camh.70129. PMID- 42892472 OWN - NLM STAT- Publisher LR - 20261023 IS - 1874-1754 (Electronic) IS - 0167-5273 (Linking) VI - 466 DP - 2026 Oct 17 TI - QTc reference ranges in eastern European children aged 6 to 18 years: a large-scale population study and comparison with international normative datasets. PG - 134990 LID - S0167-5273(26)00840-5 [pii] LID - 10.1016/j.ijcard.2026.134990 [doi] AB - BACKGROUND: QT interval corrected for heart rate (QTc) is important. Appropriate reference ranges support ECG interpretation, but data for Eastern European children remain limited. We aimed to derive age- and sex-stratified QTc reference ranges, estimate proportions exceeding cut-offs, and compare results with normative datasets. METHODS: 12‑lead ECGs from 22,335 children aged 6-18 years were obtained through the CARDIOPED screening programme in northwestern Transylvania, Romania. QTc was calculated using Bazett's formula. Age- and sex-stratified percentile curves (P2.5-P97.5) were derived using spline regression. Correlations with anthropometric variables and proportions exceeding QTc cut-offs of 440, 460, and 480 ms were assessed. Results were compared with the Davignon, Rijnbeek, Saarel, Bratincsak, and Mason datasets. RESULTS: Overall median QTc was 408.2 ms in males and 409.9 ms in females. Upper reference limits (P97.5) were 451.4 ms and 457.0 ms, respectively. The sex difference increased from 2.6 ms in the 6-12-year group to 5.7 ms in the 12-18-year group. Obesity and anthropometric variables showed weak, non-significant correlations with QTc. Values were closely aligned with Rijnbeek et al. QTc exceeded 440 ms in 6.0% of males and 460 ms in 1.2% of females; 14 children (0.06%) had a single screening QTc measurement >/=480 ms. CONCLUSIONS: QTc reference ranges in this Eastern European cohort were consistent with European paediatric normative data. Upper reference limits were approximately 450 ms in males and 460 ms in females. Proportions exceeding cut-offs describe cohort distributions, not diagnostic false-positive rates. Percentiles are statistical reference limits rather than validated clinical decision or diagnostic thresholds. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Cismaru, Gabriel AU - Cismaru G AD - 4th Department of Internal Medicine, Cardiology Rehabilitation, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. Electronic address: gabi_cismaru@yahoo.com. FAU - Lazea, Cecilia AU - Lazea C AD - Department of Pediatrics I, Emergency Clinic Hospital for Children, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. FAU - Muresan, Lucian AU - Muresan L AD - Cardiology Department, "Emile Muller" Hospital, Mulhouse, 68100, France. FAU - Gusetu, Gabriel AU - Gusetu G AD - 4th Department of Internal Medicine, Cardiology Rehabilitation, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. FAU - Rosu, Radu AU - Rosu R AD - 4th Department of Internal Medicine, Cardiology Rehabilitation, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. FAU - Pop, Dana AU - Pop D AD - 4th Department of Internal Medicine, Cardiology Rehabilitation, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. FAU - Negru, Alina AU - Negru A AD - Department of Cardiology II, University of Medicine and Pharmacy "Victor Babes", Timisoara, 300041, Romania. FAU - Cainap, Simona Sorana AU - Cainap SS AD - Department of Pediatrics II, Emergency Clinic Hospital for Children, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. LA - eng PT - Journal Article DEP - 20261017 PL - Netherlands TA - Int J Cardiol JT - International journal of cardiology JID - 8200291 SB - IM OTO - NOTNLM OT - Bazett OT - Children OT - Electrocardiography OT - LQTS OT - QTc OT - Screening COIS- Declaration of competing interest The authors declare no conflicts of interest. EDAT- 2026/10/18 05:37 MHDA- 2026/10/18 05:37 CRDT- 2026/10/18 01:48 PHST- 2026/06/29 00:00 [received] PHST- 2026/10/09 00:00 [revised] PHST- 2026/10/11 00:00 [accepted] PHST- 2026/10/18 05:37 [pubmed] PHST- 2026/10/18 05:37 [medline] PHST- 2026/10/18 01:48 [entrez] AID - S0167-5273(26)00840-5 [pii] AID - 10.1016/j.ijcard.2026.134990 [doi] PST - aheadofprint SO - Int J Cardiol. 2026 Oct 17;466:134990. doi: 10.1016/j.ijcard.2026.134990. PMID- 42891355 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261017 LR - 20261019 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Physical education and psychosocial vulnerability in adolescent suicide-related risk: a transnational cross-sectional explainable machine-learning analysis of student health survey data. PG - 1898064 LID - 10.3389/fpsyt.2026.1898064 [doi] LID - 1898064 AB - BACKGROUND: Adolescent suicide attempt is a major public health concern linked to psychosocial distress, school environment, health-risk behaviors, and physical activity patterns. This study aimed to develop an explainable XGBoost model for adolescent suicide-attempt status and to determine whether physical inactivity and low physical education (PE) participation could serve as informative school-based indicators. METHODS: Data were obtained from the Global School-based Student Health Survey conducted in Argentina in 2018, Anguilla in 2016, and Jamaica in 2017. The Argentina dataset was used for model training, while Anguilla and Jamaica were combined as an independent validation cohort. The outcome was self-reported suicide attempt during the past 12 months. Candidate predictors included demographic, anthropometric, dietary, psychosocial, violence- and injury-related, tobacco-related, sexual behavior, physical activity, and PE-related variables. An XGBoost model was developed using nested cross-validation, staged hyperparameter tuning, and Bayesian fine-tuning. Model performance was evaluated by the area under the receiver operating characteristic curve (AUC). SHAP and partial dependence plots were used for interpretation. RESULTS: A total of 27,710 adolescents were included; 5,165 (18.6%) reported at least one suicide attempt. The final model achieved an independent validation AUC of 0.7928 (95% CI: 0.7790-0.8066). The top 18 SHAP-ranked predictors retained a cumulative 10-fold cross-validated AUC of 0.7865. Loneliness was the most influential predictor, followed by sex, insomnia, early cigarette use, PE days, physical attack, school peer kindness, and physical activity. Physical inactivity and low PE participation showed nonlinear associations with predicted suicide-attempt risk. CONCLUSIONS: Loneliness and insomnia represented the psychosocial vulnerability profile, while physical inactivity and limited PE participation emerged as potentially informative school-based indicators requiring further longitudinal investigation. These findings support risk-stratified prevention strategies integrating early psychological identification with inclusive, socially supportive physical activity and PE programs. CI - Copyright (c) 2026 Liu, Guo, Ma, Shi, Ma and Li. FAU - Liu, Heyi AU - Liu H AD - Tianjin College, University of Science and Technology Beijing, Tianjin, China. FAU - Guo, Jianbin AU - Guo J AD - Quality Control Office, Kailuan Mental Health Center, Tangshan, China. FAU - Ma, Xinwei AU - Ma X AD - Department of Radiology, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China. FAU - Shi, Cheng AU - Shi C AD - Department of Cardiology, Suzhou BenQ Medical Center, Suzhou, China. FAU - Ma, Xiaoming AU - Ma X AD - Department of Cardiology, Suzhou BenQ Medical Center, Suzhou, China. AD - Department of Neurology, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China. AD - Department of Neurology, Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing, China. AD - Suzhou Key Laboratory of Integrated Stroke Prevention, Treatment and Rehabilitation, Suzhou, China. FAU - Li, Jingwei AU - Li J AD - Department of Neurology, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China. AD - Department of Neurology, Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing, China. AD - Suzhou Key Laboratory of Integrated Stroke Prevention, Treatment and Rehabilitation, Suzhou, China. AD - Suzhou Research Centre of Medical School, Nanjing University, Suzhou, China. AD - Institute of Brain Sciences, Nanjing University, Nanjing, China. AD - Nanjing Neurology Clinic Medical Center, Nanjing, China. LA - eng PT - Journal Article DEP - 20261002 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13674449 OTO - NOTNLM OT - adolescent OT - machine learning OT - mental health OT - physical education and training OT - suicide COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/17 23:38 MHDA- 2026/10/17 23:39 PMCR- 2026/10/02 CRDT- 2026/10/17 21:49 PHST- 2026/06/04 00:00 [received] PHST- 2026/09/05 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/17 23:39 [medline] PHST- 2026/10/17 23:38 [pubmed] PHST- 2026/10/17 21:49 [entrez] PHST- 2026/10/02 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1898064 [doi] PST - epublish SO - Front Psychiatry. 2026 Oct 2;17:1898064. doi: 10.3389/fpsyt.2026.1898064. eCollection 2026. PMID- 42889450 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261017 LR - 20261019 IS - 1976-1457 (Print) IS - 2005-6168 (Electronic) IS - 1976-1457 (Linking) VI - 20 IP - 5 DP - 2026 Oct TI - Comparability of food frequency questionnaires between Korean Children's Environmental Health Study (Ko-CHENS) and Korean Genome and Epidemiology Study (KoGES) in pregnant women. PG - 866-878 LID - 10.4162/nrp.2026.20.5.866 [doi] AB - BACKGROUND/OBJECTIVES: The Korean Children's Environmental Health Study (Ko-CHENS) developed a food frequency questionnaire (FFQ) to assess maternal dietary intake during pregnancy. This FFQ shares high structural similarity with the validated FFQ of the Korean Genome and Epidemiology Study (KoGES), a representative dietary assessment tool for the Korean adult population, which includes 97 of the 112 items in the Ko-CHENS FFQ. The comparability of the Ko-CHENS and KoGES FFQs among pregnant women was evaluated. SUBJECTS/METHODS: Ninety-four women recruited from Kangwon National University Hospital between December 2024 and February 2025 were included. The participants consecutively completed the Ko-CHENS and KoGES FFQs. The nutrient intakes were adjusted for the total energy intake using the residual method. Log-transformed intakes of energy, nutrients, and food groups were compared using the correlation coefficients, cross-classification percent agreement, weighted kappa statistics, and Bland-Altman plots. RESULTS: The Ko-CHENS FFQ yielded higher absolute intake estimates for energy and the majority of nutrients and food groups than the KoGES FFQ. The Pearson or Spearman correlation coefficients ranged from 0.34 (vitamin E) to 0.68 (beta-carotene) for energy and nutrients and from 0.15 (sugars and jams) to 0.77 (salted vegetables) for food groups, with median values of 0.55 and 0.61, respectively. The median proportions of the participants classified into the same or adjacent quartiles were 96.39% for energy and nutrients and 96.52% for food groups. The weighted kappa statistics ranged from 0.23 to 0.52 for energy and nutrients and from 0.06 to 0.59 for food groups, with median values of 0.38 and 0.45, respectively. The Bland-Altman plots for energy and macronutrients showed that the data points were primarily within the limits of agreement. CONCLUSION: The Ko-CHENS and KoGES FFQs showed fair-to-moderate comparability, suggesting that the Ko-CHENS FFQ can be used for ranking Korean pregnant women based on their dietary intake levels. CI - (c)2026 The Korean Nutrition Society and the Korean Society of Community Nutrition. FAU - Cho, Minsu AU - Cho M AUID- ORCID: 0009-0007-8243-1750 AD - Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 08826, Korea. FAU - Kim, Bom AU - Kim B AUID- ORCID: 0000-0001-9405-2407 AD - Department of Medical Informatics, Kangwon National University School of Medicine, Chuncheon 24341, Korea. FAU - Kim, Hyesook AU - Kim H AUID- ORCID: 0000-0002-4840-3082 AD - Department of Food and Nutrition, Wonkwang University, Iksan 54538, Korea. FAU - Na, Sunghun AU - Na S AUID- ORCID: 0000-0002-2803-8356 AD - Department of Obstetrics and Gynecology, Kangwon National University School of Medicine, Chuncheon 24341, Korea. FAU - Lee, Se Jin AU - Lee SJ AUID- ORCID: 0000-0002-8626-6250 AD - Department of Obstetrics and Gynecology, Kangwon National University School of Medicine, Chuncheon 24341, Korea. FAU - Ahn, Tae Gyu AU - Ahn TG AUID- ORCID: 0000-0002-5519-0572 AD - Department of Obstetrics and Gynecology, Kangwon National University School of Medicine, Chuncheon 24341, Korea. FAU - Son, Kyung Ho AU - Son KH AUID- ORCID: 0000-0002-2466-8334 AD - Department of AI Convergence, Kangwon National University, Chuncheon 24341, Korea. FAU - Kim, Woo Jin AU - Kim WJ AUID- ORCID: 0000-0003-2927-370X AD - Department of Medical Informatics, Kangwon National University School of Medicine, Chuncheon 24341, Korea. AD - Department of Internal Medicine and Environmental Health Center, Kangwon National University School of Medicine, Chuncheon 24341, Korea. FAU - Lee, Jung Eun AU - Lee JE AUID- ORCID: 0000-0003-1141-878X AD - Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 08826, Korea. AD - Research Institute of Human Ecology, Seoul National University, Seoul 08826, Korea. CN - Ko-CHENS Study Group LA - eng PT - Journal Article DEP - 20260918 PL - Korea (South) TA - Nutr Res Pract JT - Nutrition research and practice JID - 101311052 PMC - PMC13669475 OTO - NOTNLM OT - Diet surveys OT - comparative study OT - nutrition assessment OT - pregnancy COIS- Conflict of Interest: The authors declare no potential conflicts of interests. EDAT- 2026/10/17 23:12 MHDA- 2026/10/17 23:13 PMCR- 2026/10/01 CRDT- 2026/10/17 11:09 PHST- 2026/04/18 00:00 [received] PHST- 2026/08/07 00:00 [revised] PHST- 2026/08/27 00:00 [accepted] PHST- 2026/10/17 23:13 [medline] PHST- 2026/10/17 23:12 [pubmed] PHST- 2026/10/17 11:09 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 10.4162/nrp.2026.20.5.866 [doi] PST - ppublish SO - Nutr Res Pract. 2026 Oct;20(5):866-878. doi: 10.4162/nrp.2026.20.5.866. Epub 2026 Sep 18. PMID- 42889402 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261017 LR - 20261019 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Association between discretionary screen time and depressive symptoms in Chinese adolescents: a cross-sectional study. PG - 1957282 LID - 10.3389/fped.2026.1957282 [doi] LID - 1957282 AB - BACKGROUND: Adolescents globally exhibit growing engagement with discretionary screen time, but its association with depressive symptoms remains unclear in developing economies. OBJECTIVE: To examine the relationship between discretionary screen time and depressive symptoms among Chinese adolescents. METHODS: A cross-sectional study of 4,706 adolescents in Maoming City, Guangdong Province, China. Participants were stratified into four discretionary screen time categories: <1 h (n = 1,372), 1-2 h (n = 1,277), 2-4 h (n = 1,032), and >/=4 h (n = 1,025). Depressive symptoms were assessed using the validated CESD-9, with a cutoff score of >/=10. The primary analysis was a multilevel logistic regression model with random intercepts for school and class, adjusted for all measured covariates except BMI, anxiety and insomnia; a model additionally adjusted for BMI, anxiety and insomnia served as a sensitivity analysis. Subgroup analyses evaluated potential effect modification. RESULTS: The prevalence of depressive symptoms was 29.7% (1,398/4,706). In the primary multilevel model (random intercepts for school and class; adjusted for sociodemographic, socioeconomic and lifestyle factors, without BMI, anxiety and insomnia), compared with the <1 h reference group, the odds ratios were 1.21 (95% CI: 0.98-1.49; p = 0.082) for 1-2 h, 1.88 (95% CI: 1.52-2.33; p < 0.001) for 2-4 h, and 2.54 (95% CI: 2.04-3.16; p < 0.001) for >/=4 h; each screen-time category increment was associated with 39% higher odds of depressive symptoms (OR = 1.39, 95% CI: 1.29-1.49; p < 0.001). When additionally adjusted for BMI, anxiety and insomnia (sensitivity analysis, Model 4), the associations were attenuated but remained statistically significant for the higher categories (>/=4 h: OR = 1.69, 95% CI: 1.28-2.22; per-category OR = 1.19, 95% CI: 1.09-1.29). Subgroup analyses revealed no statistically significant evidence of effect modification (all p-interaction >0.05). CONCLUSION: Prolonged discretionary screen time is significantly associated with higher odds of depressive symptoms among Chinese adolescents, indicating a graded association that strengthens with increasing screen time. These findings are relevant to public-health monitoring of discretionary screen use in adolescents. CI - (c) 2026 Xu, Yang, Wang and Wang. FAU - Xu, Zhi AU - Xu Z AD - Department of Neurosis and Psychosomatic Diseases, The Third Hospital of Quzhou, Quzhou, Zhejiang, China. FAU - Yang, Shuye AU - Yang S AD - Department of Neurology, Binzhou People's Hospital, Binzhou, Shandong, China. FAU - Wang, Shibin AU - Wang S AD - Guangdong Mental Health Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China. FAU - Wang, Xing AU - Wang X AD - Department of Neurosis and Psychosomatic Diseases, Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou Normal University, Huzhou, Zhejiang, China. LA - eng PT - Journal Article DEP - 20261001 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13669189 OTO - NOTNLM OT - Chinese adolescents OT - adolescents OT - cross-sectional study OT - depressive symptoms OT - discretionary screen time COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/17 23:12 MHDA- 2026/10/17 23:13 PMCR- 2026/10/01 CRDT- 2026/10/17 10:56 PHST- 2026/08/03 00:00 [received] PHST- 2026/09/17 00:00 [revised] PHST- 2026/09/22 00:00 [accepted] PHST- 2026/10/17 23:13 [medline] PHST- 2026/10/17 23:12 [pubmed] PHST- 2026/10/17 10:56 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 10.3389/fped.2026.1957282 [doi] PST - epublish SO - Front Pediatr. 2026 Oct 1;14:1957282. doi: 10.3389/fped.2026.1957282. eCollection 2026. PMID- 42889239 OWN - NLM STAT- MEDLINE DCOM- 20261017 LR - 20261019 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Regional differences in obesity risk, sedentary behavior, and dietary patterns among university students in Saudi Arabia: a multi-region cross-sectional study. PG - 1980253 LID - 10.3389/fpubh.2026.1980253 [doi] LID - 1980253 AB - BACKGROUND: Overweight and obesity are rising among Saudi university students. Guided by Popkin's nutrition transition theory, this study examined regional variation in overweight/obesity, sedentary behavior, and nutrition-transition dietary patterns. METHODS: This cross-sectional study (March-May 2023) recruited 564 students from four Saudi administrative regions using a multistage sampling approach. Three colleges per university were selected across three academic domains; within each college, one male and one female class per academic level were invited; all eligible students completed the questionnaire. Students with prior type 2 diabetes were excluded. BMI was calculated from self-reported weight and height (overweight/obesity: >/= 25.0 kg/m(2)). Dietary patterns were identified using principal-component analysis of 17 food groups from a validated 66-item food frequency questionnaire. Physical activity was assessed via IPAQ-SF (sufficient: >/= 150 min/week); composite sedentary behavior exposure was classified as low (< 8 h/day), moderate (8-12 h/day), or high (> 12 h/day). Logistic regression adjusted for sex, age, income, college type, region, and smoking. RESULTS: Overweight/obesity prevalence was 17.9% (n = 100/558); as BMI relied on self-reported anthropometrics, this is a conservative lower bound. A marked regional gradient was observed: 27.8% of Riyadh students were overweight/obese versus 8.8% in Makkah (chi (2) = 25.48, p < 0.001). Region showed the strongest association with overweight/obesity after adjustment: Riyadh (aOR = 4.62, 95% CI 2.23-9.59, p < 0.001) and male sex (aOR = 1.96, 95% CI 1.04-3.71, p = 0.037) were the only significant predictors. Composite sedentary behavior exposure was high: 82.3% were moderately or highly sedentary (>/= 8 h/day), dominated by mobile phone use (3.75 h/day) and academic study (3.35 h/day). Sedentary behavior was higher in overweight/obese students (15.5 vs. 13.9 h/day; p = 0.043). Nutrition-transition dietary patterns were not associated with overweight/obesity (aOR = 0.93, p = 0.543). CONCLUSION: Region showed the strongest association with overweight/obesity, with Riyadh students at four-fold higher risk than Makkah students, suggesting that regional structural and environmental factors may contribute to obesity risk in this population. Prolonged mobile phone use and screen-based sedentarism were prevalent and associated with overweight/obesity. Campus interventions targeting sedentary screen behavior and regional food environments, particularly in Riyadh, are warranted; future studies should employ direct anthropometry to obtain unbiased prevalence estimates. CI - Copyright (c) 2026 Alkhraiji and Alaqil. FAU - Alkhraiji, Mohummed H AU - Alkhraiji MH AD - Department of Exercise Physiology, College of Sport Sciences and Physical Activity, King Saud University, Riyadh, Saudi Arabia. FAU - Alaqil, Abdulrahman I AU - Alaqil AI AD - College of Education, Department of Physical Education, King Faisal University, Al-Ahsa, Saudi Arabia. LA - eng PT - Journal Article DEP - 20261001 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Male MH - Cross-Sectional Studies MH - Female MH - *Sedentary Behavior MH - *Obesity/epidemiology MH - *Students/statistics & numerical data MH - Universities MH - Young Adult MH - *Diet/statistics & numerical data MH - Prevalence MH - Risk Factors MH - Adult MH - *Feeding Behavior MH - Surveys and Questionnaires MH - Overweight/epidemiology MH - Body Mass Index MH - Exercise MH - Adolescent PMC - PMC13668806 OTO - NOTNLM OT - Saudi Arabia OT - dietary patterns OT - nutrition transition OT - obesity OT - overweight OT - regional variation OT - sedentary behavior OT - self-reported BMI COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/17 23:13 MHDA- 2026/10/17 23:14 PMCR- 2026/10/01 CRDT- 2026/10/17 09:27 PHST- 2026/08/27 00:00 [received] PHST- 2026/09/18 00:00 [revised] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/17 23:14 [medline] PHST- 2026/10/17 23:13 [pubmed] PHST- 2026/10/17 09:27 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1980253 [doi] PST - epublish SO - Front Public Health. 2026 Oct 1;14:1980253. doi: 10.3389/fpubh.2026.1980253. eCollection 2026. PMID- 42889191 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261017 LR - 20261019 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Does learning burnout link physical exercise and problematic short-video use? Evidence from a three-wave random-intercept cross-lagged panel model and supplementary machine-learning analysis among Chinese high school students. PG - 1929181 LID - 10.3389/fpsyg.2026.1929181 [doi] LID - 1929181 AB - BACKGROUND: Problematic short-video use has become a growing behavioral health concern among adolescents, yet its longitudinal links with physical exercise and learning burnout remain insufficiently understood. This study examined the within-person bidirectional associations among physical exercise, learning burnout, and problematic short-video use, tested whether learning burnout served as a longitudinal pathway linking physical exercise to later problematic short-video use, and explored the predictive value of these variables for subsequent problematic short-video use. METHODS: A three-wave longitudinal survey with 6-month intervals was conducted among 1,327 students aged 16-18 years from five high schools in Yunnan Province, China. Physical exercise, learning burnout, and problematic short-video use were assessed using the Physical Activity Rating Scale-3 (PARS-3), the Adolescent Student Burnout Inventory, and the Short-Video Addiction Scale. Random-intercept cross-lagged panel modeling was used to separate stable between-person differences from within-person fluctuations while controlling for demographic and educational covariates. The longitudinal indirect association was estimated using 5,000 bias-corrected bootstrap samples. Supplementary ridge regression and extreme gradient boosting models, using nested cross-validation and a holdout test set, examined the incremental predictive value of physical exercise and learning burnout for later problematic short-video use. RESULTS: At the between-person level, higher long-term physical exercise was associated with lower learning burnout and problematic short-video use, whereas higher learning burnout was associated with higher problematic short-video use. At the within-person level, higher-than-usual physical exercise predicted lower subsequent learning burnout and problematic short-video use. Learning burnout and problematic short-video use showed positive reciprocal associations over time, and both predicted lower subsequent physical exercise. The longitudinal indirect association from physical exercise to later problematic short-video use through learning burnout was statistically significant but small. In supplementary machine-learning analyses, the best holdout R (2) was 0.311, but adding physical exercise and learning burnout did not improve prediction beyond prior problematic short-video use. SHAP results from the extended XGBoost model were therefore interpreted as exploratory feature attributions. CONCLUSION: Physical exercise, learning burnout, and problematic short-video use showed interconnected longitudinal associations among Chinese high school students. Learning burnout may represent one small longitudinal indirect pathway linking physical exercise to later problematic short-video use, while recent problematic short-video use provides the most informative signal for future risk. These findings may inform the development and evaluation of school-based health-promotion strategies that support physical exercise, address learning burnout, and respond to recent problematic-use symptoms. CI - Copyright (c) 2026 Yin, Peng, Chen, Wang, Liu, Xie and Gao. FAU - Yin, Tian AU - Yin T AD - Xiangtan University, Xiangtan, Hunan, China. AD - School of Physical Education, Yunnan Minzu University, Kunming, Yunnan, China. FAU - Peng, Yanfeng AU - Peng Y AD - School of Physical Education, Yunnan Minzu University, Kunming, Yunnan, China. FAU - Chen, Longjiang AU - Chen L AD - School of Physical Education, Yunnan Normal University, Kunming, Yunnan, China. FAU - Wang, Zetian AU - Wang Z AD - School of Physical Education, Yunnan Minzu University, Kunming, Yunnan, China. FAU - Liu, Xu AU - Liu X AD - School of Physical Education, Yunnan Minzu University, Kunming, Yunnan, China. FAU - Xie, Changcheng AU - Xie C AD - Hezhou University, Hezhou, Guangxi, China. FAU - Gao, Zeng AU - Gao Z AD - Xiangtan University, Xiangtan, Hunan, China. LA - eng PT - Journal Article DEP - 20261001 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13668801 OTO - NOTNLM OT - high school students OT - learning burnout OT - machine learning OT - physical exercise OT - problematic short-video use OT - random-intercept cross-lagged panel model COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/17 23:13 MHDA- 2026/10/17 23:14 PMCR- 2026/10/01 CRDT- 2026/10/17 08:49 PHST- 2026/07/05 00:00 [received] PHST- 2026/08/30 00:00 [revised] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/10/17 23:14 [medline] PHST- 2026/10/17 23:13 [pubmed] PHST- 2026/10/17 08:49 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1929181 [doi] PST - epublish SO - Front Psychol. 2026 Oct 1;17:1929181. doi: 10.3389/fpsyg.2026.1929181. eCollection 2026. PMID- 42889007 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261017 LR - 20261019 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Policy themes and instruments in WHO and UNICEF child food-environment guidance, 2015-2025: a computational content analysis. PG - 1935052 LID - 10.3389/fnut.2026.1935052 [doi] LID - 1935052 AB - In children's food environments, global guidance can shape policy discourse and instrument choice, but its content does not establish implementation or outcomes. In 2015-2025, the World Health Organization (WHO) and the United Nations Children's Fund (UNICEF) published English-language guidance at the global level. A documented search, 2-author screening, and author-decision-masked expert review produced a corpus of 22 expert-refrozen documents (1,099 pages; 1,259 primary chunks). The BERTopic with document-capped discovery yielded six provisional clusters: food-marketing restrictions and children's rights; obesity burden; nutrition-sensitive social protection and service delivery; school, physical activity, and healthy food environments; infant and young child food promotion controls; and business engagement and food-industry governance. Among 978 chunks, marketing restrictions and children's rights accounted for 332 assigned chunks (33.9%). The expert accepted all descriptors and changed three of seven boundary decisions; applying those decisions and rerunning the full pipeline retained six identity-mapped clusters. Fixed-corpus seed and zoning diagnostics were favorable, but context expansion produced seven clusters and dominant-source removal substantially reorganized two source-concentrated clusters. To assess coding reliability, an 84-chunk exercise was archived under the earlier 19-document freeze; issuer and period profiles were descriptive. The study therefore provides a bound, auditable map rather than a stable taxonomy. Nutritional health literacy is a downstream interpretive application: no actual implementation process or literacy, behavioral, dietary-quality, or health outcome was measured. CI - Copyright (c) 2026 Xing and Wu. FAU - Xing, Lu AU - Xing L AD - School of Preschool Education, Changsha Normal University, Changsha, China. AD - School of Education, Faculty of Social Sciences and Leisure Management, Taylor's University, Subang Jaya, Malaysia. FAU - Wu, Xueqi AU - Wu X AD - Taylor's Culinary Institute, Faculty of Social Sciences and Leisure Management, Taylor's University, Subang Jaya, Malaysia. LA - eng PT - Journal Article DEP - 20261001 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13668553 OTO - NOTNLM OT - BERTopic OT - child nutrition OT - computational content analysis OT - food environments OT - food governance OT - nutritional health literacy OT - policy discourse OT - policy implementation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/17 23:13 MHDA- 2026/10/17 23:14 PMCR- 2026/10/01 CRDT- 2026/10/17 06:11 PHST- 2026/07/11 00:00 [received] PHST- 2026/09/16 00:00 [revised] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/10/17 23:14 [medline] PHST- 2026/10/17 23:13 [pubmed] PHST- 2026/10/17 06:11 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 10.3389/fnut.2026.1935052 [doi] PST - epublish SO - Front Nutr. 2026 Oct 1;13:1935052. doi: 10.3389/fnut.2026.1935052. eCollection 2026. PMID- 42886664 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 10 DP - 2026 TI - Validation of HemoCue method and development of a revised hemoglobin cut-off to detect anemia in children aged 6-24-months. PG - e0346506 LID - 10.1371/journal.pone.0346506 [doi] LID - e0346506 AB - BACKGROUND: Accurate hemoglobin (Hb) measurement is essential for determining anemia prevalence at the population level. The HemoCue method, commonly used in resource poor settings, has been shown to overestimate Hb levels compared to the direct cyanmethemoglobin (DCM) method, leading to an underestimation of anemia. We aimed to validate the HemoCue method against the DCM method and establish an optimal cut-off value for diagnosing anemia in children under two. METHODS: Data were collected from children under two years of age as part of the Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development study in Bangladesh, conducted in Mirpur, Dhaka, from February 2010 to February 2017. Using HemoCue 201 instrument and DCM method, Hb levels were measured in 846 venous blood samples collected from 589 children. Quadratic regression was explored to derive a correction factor; however, substantial dispersion in HemoCue measurements prevented establishment of a reliable correction model. Youden's Index was used to identify the optimal cut‑off. While it provided a strong threshold, we prioritized achieving at least 70% sensitivity and specificity to confirm balanced diagnostic performance. RESULTS: The median (IQR) Hb concentrations estimated by HemoCue and DCM were 11.6 (10.5, 12.5) g/dL and 10.8 (10.1, 11.5) g/dL, respectively. Using a cut-off of <10.5 g/dL for anemia, the prevalence was significantly higher with the DCM method (35.2% vs. 23.2%, p < 0.001). Considering DCM as the gold standard, the sensitivity and specificity of the HemoCue method were 93% and 53%, respectively. In the test/train analysis, the newly identified cut-off of 11.00 g/dL, indicated an anemia prevalence of 34.2% in the testing dataset, with a sensitivity of 84% and specificity of 69%. CONCLUSION: This study highlights substantial variability between HemoCue and DCM hemoglobin measurements, which prevented development of a reliable correction factor. The proposed HemoCue cut-off of 11.0 g/dL may improve anemia detection in children under two years of age when compared with the currently recommended threshold. CI - Copyright: (c) 2026 Mahfuz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Mahfuz, Mustafa AU - Mahfuz M AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. FAU - Khan, Ar-Rafi AU - Khan AR AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. FAU - Hasan, S M Tafsir AU - Hasan SMT AUID- ORCID: 0000-0002-6062-4072 AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. FAU - Hossain, Md Shabab AU - Hossain MS AUID- ORCID: 0000-0002-2862-8639 AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. FAU - Rezwan, A H M AU - Rezwan AHM AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. FAU - Mahfuz, Mehjabin Tishan AU - Mahfuz MT AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. FAU - Alam, Md Ashraful AU - Alam MA AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. FAU - Ahmed, Tahmeed AU - Ahmed T AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. AD - Office of Executive Director, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. LA - eng PT - Journal Article PT - Validation Study DEP - 20261016 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Hemoglobins) SB - IM MH - Humans MH - *Hemoglobins/analysis MH - *Anemia/diagnosis/blood/epidemiology MH - Infant MH - Male MH - Child, Preschool MH - Female MH - Sensitivity and Specificity MH - Bangladesh/epidemiology MH - Prevalence PMC - PMC13674700 COIS- The authors have declared that no competing interests exist. EDAT- 2026/10/16 19:05 MHDA- 2026/10/16 19:06 PMCR- 2026/10/16 CRDT- 2026/10/16 13:35 PHST- 2026/03/20 00:00 [received] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/10/16 19:06 [medline] PHST- 2026/10/16 19:05 [pubmed] PHST- 2026/10/16 13:35 [entrez] PHST- 2026/10/16 00:00 [pmc-release] AID - PONE-D-26-09930 [pii] AID - 10.1371/journal.pone.0346506 [doi] PST - epublish SO - PLoS One. 2026 Oct 16;21(10):e0346506. doi: 10.1371/journal.pone.0346506. eCollection 2026. PMID- 42885213 OWN - NLM STAT- Publisher LR - 20261028 IS - 1536-4801 (Electronic) IS - 0277-2116 (Linking) DP - 2026 Oct 15 TI - Multimodal prediction of infliximab initiation within 6 months after initiation of conventional therapy in pediatric Crohn's disease: A multicenter algorithm development and validation study. LID - 10.1002/jpn3.70602 [doi] AB - OBJECTIVES: Early prediction of treatment course in pediatric Crohn's disease (CD) remains limited despite the importance of timely biologic therapy. We developed and externally validated a multimodal model integrating colonoscopy images and clinical data to predict infliximab initiation within 6 months after conventional therapy. METHODS: We collected data from children newly diagnosed with CD at three hospitals: Seoul National University Bundang Hospital for internal validation, Kyung Hee University Medical Center, and Soonchunhyang University Bucheon Hospital for external validation. Each patient contributed 7 endoscopic images and 20 clinical variables. An attention-based multiple-instance learning framework aggregated endoscopic images into a patient-level representation and integrated them with clinical features. The imaging encoder used a ResNet-50 backbone pretrained with momentum contrastive learning on GastroNet-5M, and clinical features were encoded using a multilayer perceptron. Performance was assessed using the area under the receiver operating characteristic curve (AUROC), balanced accuracy, precision, recall, and F1 score. Explainable AI was evaluated using attention maps (image data) and SHAP values (tabular data). RESULTS: Seventy-seven children were included for model development and internal validation, with external validation performed in two independent cohorts (n = 10 and n = 20). The multimodal model achieved an AUROC of 0.839 and balanced accuracy of 0.732 in the discovery cohort. External-validation AUROCs were 0.857 and 0.688. SHapley Additive exPlanation analysis identified immunoglobulin G, body mass index, prealbumin, hematocrit, and age as key predictors. Attention maps highlighted inflamed mucosa and ulcerative lesions. CONCLUSION: A multimodal model integrating colonoscopy images with clinical data showed promising performance for predicting infliximab initiation within 6 months after conventional therapy in pediatric CD. Multimodal information may support early risk stratification and identify patients who could benefit from earlier biologic intervention. CI - (c) 2026 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Kim, Seon Young AU - Kim SY AUID- ORCID: 0000-0001-6433-0242 AD - Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, South Korea. FAU - Hwang, Seung Ha AU - Hwang SH AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Electronics and Information Convergence Engineering, Kyung Hee University, Yongin, South Korea. FAU - Yeo, Dongjin AU - Yeo D AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. FAU - Kim, Juyeong AU - Kim J AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Regulatory Science, Kyung Hee University, Seoul, South Korea. FAU - Hwangbo, Gyeom AU - Hwangbo G AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Precision Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. FAU - Kim, Do Hyun AU - Kim DH AUID- ORCID: 0000-0003-0064-1732 AD - Department of Pediatrics, Soonchunhyang University Seoul Hospital, Seoul, Korea. FAU - Lee, Yoo Min AU - Lee YM AD - Department of Pediatrics, Soonchunhyang University Bucheon Hospital, Bucheon, Korea. FAU - Woo, Selin AU - Woo S AUID- ORCID: 0000-0001-7961-2074 AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. FAU - Hahn, Jong Woo AU - Hahn JW AUID- ORCID: 0000-0001-6331-1314 AD - Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea. AD - Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, South Korea. FAU - Yon, Dong Keon AU - Yon DK AUID- ORCID: 0000-0003-1628-9948 AD - Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, South Korea. AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Electronics and Information Convergence Engineering, Kyung Hee University, Yongin, South Korea. AD - Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Regulatory Science, Kyung Hee University, Seoul, South Korea. AD - Department of Precision Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. LA - eng GR - RS-2024-00509257/Ministry of Science and ICT, South Korea/ GR - IITP-2026-RS-2024-00438239/Ministry of Science and ICT, South Korea/ GR - RS-2025-02220492/Ministry of Health and Welfare/ PT - Journal Article DEP - 20261015 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM OTO - NOTNLM OT - SHAP OT - biologic therapy OT - endoscopic imaging OT - inflammatory bowel disease EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:33 CRDT- 2026/10/16 02:23 PHST- 2026/09/09 00:00 [revised] PHST- 2026/06/08 00:00 [received] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 05:33 [medline] PHST- 2026/10/16 02:23 [entrez] AID - 10.1002/jpn3.70602 [doi] PST - aheadofprint SO - J Pediatr Gastroenterol Nutr. 2026 Oct 15. doi: 10.1002/jpn3.70602. PMID- 42884725 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Oct 5 TI - Turkish Adaptation of the Clean Food Consumerism Scale: A Validity and Reliability Study. LID - 10.3390/nu18193274 [doi] LID - 3274 AB - Background: Clean food consumerism reflects consumers' preferences for foods perceived as natural, authentic, transparent, and health-promoting. This study aimed to culturally adapt the Clean Food Consumerism Scale (CFCS) into Turkish and evaluate its psychometric properties. Methods: The CFCS was translated, back-translated, reviewed by experts, pilot-tested, and psychometrically evaluated. For the pilot study and factor analyses, the Turkish version was administered to 1637 adults, who were allocated to three mutually exclusive subsamples: n = 180 for the pilot study, n = 500 for EFA, and n = 957 for CFA. An additional, separate sample of 124 participants completed the CFCS twice at a three-week interval for the test-retest analysis. Internal consistency, construct validity, convergent validity, discriminant validity, criterion validity, and test-retest reliability were assessed using Cronbach's alpha, item-total correlations, EFA, CFA, composite reliability (CR), average variance extracted (AVE), the Fornell-Larcker criterion, heterotrait-monotrait (HTMT) ratios, correlations with the Sustainable and Healthy Eating Behaviors Scale (SHEBS), and test-retest correlations. Results: The 18-item CFCS demonstrated excellent internal consistency (Cronbach's alpha = 0.948). Sampling adequacy was supported by the KMO value (0.927) and significant Bartlett's test (chi(2) = 7525.229, p < 0.001). EFA supported a five-factor structure comprising Perceived Health Benefits, Production Process Transparency, Authenticity, Perceived Ease of Use, and Familiarity, explaining 80.92% of the total variance. CFA supported the five-factor model. After adding one content-justified residual covariance between two closely related Perceived Health Benefits items, the final model showed acceptable fit (chi(2) = 641.39, df = 124, p < 0.001; CFI = 0.965, TLI = 0.956, NFI = 0.957, RMSEA = 0.066 [90% CI 0.061-0.071], SRMR = 0.047, GFI = 0.926, AGFI = 0.899). Standardized factor loadings ranged from 0.748 to 0.938, composite reliability from 0.873 to 0.940, and average variance extracted from 0.697 to 0.771. HTMT ratios for all factor pairs remained below 0.685 and the Fornell-Larcker criterion was satisfied for every factor, supporting discriminant validity. Test-retest reliability over three weeks was excellent (r = 0.889, p < 0.001), and CFCS scores were positively correlated with SHEBS scores (r = 0.441, p < 0.001). Conclusions: The Turkish version of the CFCS demonstrated strong validity, reliability, and temporal stability while preserving the original five-factor structure. It provides a psychometrically sound instrument for assessing clean food consumerism among Turkish-speaking adults and may support future research in nutrition, public health, sustainability, and consumer behavior. FAU - Sipahi Uygur, Simge AU - Sipahi Uygur S AUID- ORCID: 0000-0002-3070-0601 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. FAU - Cakir Bicer, Nihan AU - Cakir Bicer N AUID- ORCID: 0000-0002-7581-9083 AD - Department of Molecular Gastroenterology and Hepatology, Institute of Gastroenterology and Hepatology, Kocaeli University, Kocaeli 41001, Turkiye. FAU - Ones, Ece AU - Ones E AUID- ORCID: 0000-0002-9936-8475 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. AD - Department of Nutrition and Dietetics, Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. FAU - Roberts, Sena AU - Roberts S AUID- ORCID: 0000-0002-6052-109X AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. FAU - Koksal, Selen AU - Koksal S AUID- ORCID: 0000-0002-1181-3619 AD - Department of Culinary, Vocational School, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. FAU - Turker, Perim Fatma AU - Turker PF AUID- ORCID: 0000-0002-4254-3711 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. AD - Department of Nutrition and Dietetics, Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. FAU - Bas, Murat AU - Bas M AUID- ORCID: 0000-0002-0494-301X AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. AD - Department of Nutrition and Dietetics, Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. LA - eng PT - Journal Article PT - Validation Study DEP - 20261005 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Turkey MH - Female MH - Reproducibility of Results MH - Male MH - Adult MH - Psychometrics MH - *Consumer Behavior MH - Middle Aged MH - Pilot Projects MH - Young Adult MH - Surveys and Questionnaires MH - *Diet, Healthy MH - *Food Preferences/psychology MH - Adolescent PMC - PMC13666638 OTO - NOTNLM OT - Turkish adaptation OT - clean food consumerism OT - psychometric evaluation OT - reliability OT - scale adaptation OT - sustainable nutrition OT - validity COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/10/05 CRDT- 2026/10/16 01:10 PHST- 2026/07/01 00:00 [received] PHST- 2026/09/21 00:00 [revised] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/10/05 00:00 [pmc-release] AID - nu18193274 [pii] AID - nutrients-18-03274 [pii] AID - 10.3390/nu18193274 [doi] PST - epublish SO - Nutrients. 2026 Oct 5;18(19):3274. doi: 10.3390/nu18193274. PMID- 42884723 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Oct 5 TI - Association Between Eating Attitudes and Dental Caries Experience in Young Adults Attending a Private Dental Practice: A Cross-Sectional Study. LID - 10.3390/nu18193273 [doi] LID - 3273 AB - BACKGROUND/OBJECTIVES: Eating attitudes may be linked to oral health through behavioral and lifestyle mechanisms, but data on young adults remain limited. The primary objective was to assess the association between dietary attitudes and caries experience in young adults recruited from a private dental practice. Secondary analyses examined the psychometric properties of the EAT-40 and the relationships of its scores with BMI, oral health behaviors, and lifestyle factors. METHODS: A cross-sectional study included 366 adults aged 18-25 years recruited by convenience sampling from a private dental practice in Iasi. Eating attitudes were assessed using the EAT-40, oral health behaviors using the HU-DBI, and caries experience using the DMFT and DMFS indices. BMI was calculated based on self-reported weight and height. Exploratory factor analysis, Spearman correlations, negative binomial regression, and multiple linear regression were used. RESULTS: The EAT-40 showed good internal consistency (alpha = 0.887), and the three-factor solution explained 36.6% of the variance. The total EAT-40 score showed weak positive correlations with DMFT and DMFS (rho = 0.146; p = 0.005 for both), but was not significantly associated with DMFS in the fully adjusted model (IRR = 1.003; 95% CI: 0.997-1.010; p = 0.293) or in the sensitivity analysis (IRR = 1.005; 95% CI: 0.999-1.012; p = 0.122). None of the three EAT-40 dimensions was significantly associated with DMFS after adjustment. The total EAT-40 score was not significantly associated with BMI. Daily smoking was associated with higher DMFS values, whereas occasional smoking was not. CONCLUSIONS: In the study sample, EAT-40 scores were weakly associated with caries experience, but not independently with BMI. The results regarding EAT-40 dimensions remain exploratory, and the cross-sectional design does not allow for causal conclusions. FAU - Armencia, Adina Oana AU - Armencia AO AUID- ORCID: 0000-0003-0921-4382 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Nicolau, Andrei AU - Nicolau A AUID- ORCID: 0000-0002-1423-3820 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Vasluianu, Roxana Ionela AU - Vasluianu RI AUID- ORCID: 0000-0003-0867-1135 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Bolos, Alexandra AU - Bolos A AUID- ORCID: 0009-0007-1247-0383 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Balcos, Carina Ana-Maria AU - Balcos CA AUID- ORCID: 0000-0001-7712-1319 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Ioanid, Nicoleta AU - Ioanid N AUID- ORCID: 0009-0003-7558-3730 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Condurache, Gabriel AU - Condurache G AD - Private Dental Practice, 700106 Iasi, Romania. FAU - Vitalariu, Anca Mihaela AU - Vitalariu AM AUID- ORCID: 0000-0002-8341-8810 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Gradinaru, Irina AU - Gradinaru I AUID- ORCID: 0000-0002-1676-4668 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Macovei, Georgiana AU - Macovei G AUID- ORCID: 0000-0003-1152-4216 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. LA - eng PT - Journal Article DEP - 20261005 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - *Dental Caries/epidemiology/psychology MH - Young Adult MH - Male MH - Adult MH - Adolescent MH - *Feeding Behavior/psychology MH - Oral Health MH - Body Mass Index MH - DMF Index MH - Health Behavior MH - Life Style MH - Psychometrics PMC - PMC13666866 OTO - NOTNLM OT - body mass index OT - dental caries OT - feeding behavior OT - health behavior OT - young adult COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/10/05 CRDT- 2026/10/16 01:10 PHST- 2026/09/09 00:00 [received] PHST- 2026/09/30 00:00 [revised] PHST- 2026/10/02 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/10/05 00:00 [pmc-release] AID - nu18193273 [pii] AID - nutrients-18-03273 [pii] AID - 10.3390/nu18193273 [doi] PST - epublish SO - Nutrients. 2026 Oct 5;18(19):3273. doi: 10.3390/nu18193273. PMID- 42884717 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Oct 3 TI - Association of Nutritional Status at Diagnosis with Disease Course in Pediatric Inflammatory Bowel Disease. LID - 10.3390/nu18193266 [doi] LID - 3266 AB - BACKGROUND: Growth impairment is a major component of pediatric inflammatory bowel disease (IBD), yet the prognostic role of baseline nutritional status remains debated. We assessed the impact of nutritional status at diagnosis on subsequent medical and surgical disease course. METHODS: We retrospectively studied 183 children with IBD (84 Crohn's disease, 99 ulcerative colitis) followed for at least 18 months. Patients were classified at diagnosis using BMI Z-scores as underweight (n = 35), normal weight (n = 123), or overweight/obese (n = 25). Multivariable regression models-adjusted for diagnosis, biological sex, age at diagnosis, and extraintestinal manifestations/comorbidities-evaluated relapse burden, surgical resection, and longitudinal anthropometric recovery at last follow-up. RESULTS: Baseline underweight status was not independently associated with a higher relapse burden or time to first relapse. A sensitivity analysis excluding surgically resected patients showed higher estimated relapse rates for underweight patients, though these did not reach statistical significance. In exploratory analyses, baseline underweight showed a borderline, non-significant association with subsequent surgical resection (adjusted OR 2.68, 95% CI 0.97-7.27; p = 0.056), warranting validation in larger prospective cohorts. Exploratory VEO-IBD analyses were limited by small subgroup size; within UC, a higher crude resection frequency was observed in VEO-UC than in older-onset UC (15.0% vs. 1.3%), but this finding should be interpreted cautiously. At follow-up, 85.7% of initially underweight patients reached normal weight. Higher baseline BMI Z-score was independently associated with higher follow-up BMI Z-score, whereas therapeutic escalation and total relapse burden were not independently associated with follow-up BMI Z-score. Persistent stunting was very rare (1.9%), precluding multivariable analysis. CONCLUSIONS: Baseline underweight showed a suggestive but non-significant association with subsequent surgical resection, warranting confirmation in larger prospective cohorts, while it was not independently associated with medical disease instability. Substantial weight recovery occurred during pediatric IBD follow-up. Baseline BMI Z-score was associated with BMI Z-score at follow-up, although substantial between-patient variability remained unexplained. FAU - Morelli, Annalisa AU - Morelli A AUID- ORCID: 0000-0002-9052-0266 AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. AD - Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", Pediatrics Section, University of Salerno, 84081 Baronissi, Italy. FAU - Caprarelli, Michela AU - Caprarelli M AUID- ORCID: 0000-0001-7166-6545 AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. AD - Department of Pediatrics, Universita Cattolica del Sacro Cuore, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00168 Rome, Italy. FAU - Ruiz, Roberta Giusy AU - Ruiz RG AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - Mazzoli, Bianca AU - Mazzoli B AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. AD - Department of Pediatrics, Universita Cattolica del Sacro Cuore, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00168 Rome, Italy. FAU - Salatto, Alessia AU - Salatto A AUID- ORCID: 0000-0002-3613-4823 AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. AD - Department of Pediatrics, University Federico II of Naples, Via Sergio Pansini 5, 80131 Naples, Italy. FAU - Knafelz, Daniela AU - Knafelz D AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - Bracci, Fiammetta AU - Bracci F AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - Cardile, Sabrina AU - Cardile S AUID- ORCID: 0000-0003-2912-3154 AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - Bolasco, Giulia AU - Bolasco G AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - Trovato, Chiara Maria AU - Trovato CM AUID- ORCID: 0000-0003-3869-1815 AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - De Angelis, Paola AU - De Angelis P AD - Gastroenterology, Digestive Endoscopy and Nutrition Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - Romeo, Erminia Francesca AU - Romeo EF AD - Gastroenterology, Digestive Endoscopy and Nutrition Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - Diamanti, Antonella AU - Diamanti A AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. LA - eng PT - Journal Article DEP - 20261003 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - Pediatric Crohn's disease SB - IM MH - Humans MH - *Nutritional Status MH - Female MH - Male MH - Retrospective Studies MH - Child MH - Thinness/complications MH - Recurrence MH - Adolescent MH - *Colitis, Ulcerative/diagnosis/complications/physiopathology MH - Body Mass Index MH - Disease Progression MH - *Crohn Disease/diagnosis/complications/physiopathology MH - Prognosis MH - *Inflammatory Bowel Diseases/diagnosis/complications MH - Child, Preschool PMC - PMC13667242 OTO - NOTNLM OT - IBD OT - disease course OT - nutritional status COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/10/03 CRDT- 2026/10/16 01:10 PHST- 2026/08/23 00:00 [received] PHST- 2026/09/19 00:00 [revised] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/10/03 00:00 [pmc-release] AID - nu18193266 [pii] AID - nutrients-18-03266 [pii] AID - 10.3390/nu18193266 [doi] PST - epublish SO - Nutrients. 2026 Oct 3;18(19):3266. doi: 10.3390/nu18193266. PMID- 42884698 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Oct 1 TI - Fit-Ideal Internalisation and Disordered Eating in Adolescent Girls: Psychometric Evaluation and Incremental Validity of the Fit Internalization Test. LID - 10.3390/nu18193248 [doi] LID - 3248 AB - OBJECTIVES: The present study aimed to validate the Lithuanian translation of the Fit Ideal Internalization Test (FIIT) in adolescent girls. METHODS: A total of 1067 girls (mean age = 17.27, SD = 0.61; age range = 15-19 years) participated in the study. FIIT, muscular ideal internalization, body dissatisfaction (BD), disordered eating (DE), body appreciation (BA), and exercise motivation were assessed. RESULTS: Exploratory factor analysis (n = 534) replicated the original three-factor structure, explaining 74.43% of the total variance. Confirmatory factor analysis (n = 533) supported the three-factor model, with strong factor loadings. Composite reliability was excellent (McDonald's omega = 0.919-0.969). Measurement invariance was established across sport participation groups, and sport-involved girls reported higher Fit Drive, Fit Overvaluation, and FIIT total scores than non-sport-involved girls. All FIIT subscales were positively associated with muscular internalization, BD, and DE and negatively associated with BA, while Fit Idealisation and Fit Overvaluation showed weak negative associations with autonomous exercise motivation, consistent with the hypothesised pattern of associations. The FIIT explained significant additional variance in DE beyond body mass index, BD, and muscular ideal internalization, with Fit Idealisation showing the strongest unique association (beta = 0.401, p < 0.001). CONCLUSIONS: The Lithuanian FIIT appears to be a psychometrically sound instrument for assessing fit ideal internalization among Lithuanian adolescent girls. FAU - Baceviciene, Migle AU - Baceviciene M AUID- ORCID: 0000-0002-9819-2316 AD - Department of Physical and Social Education, Lithuanian Sports University, Sporto 6, 44221 Kaunas, Lithuania. FAU - Balciuniene, Vaiva AU - Balciuniene V AUID- ORCID: 0000-0002-9986-9771 AD - Department of Physical and Social Education, Lithuanian Sports University, Sporto 6, 44221 Kaunas, Lithuania. FAU - Jankauskiene, Rasa AU - Jankauskiene R AUID- ORCID: 0000-0001-5950-0884 AD - Institute of Sport Science and Innovations, Lithuanian Sports University, Sporto 6, 44221 Kaunas, Lithuania. LA - eng PT - Journal Article PT - Validation Study DEP - 20261001 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Adolescent MH - *Feeding and Eating Disorders/psychology/diagnosis MH - *Psychometrics MH - *Body Image/psychology MH - Reproducibility of Results MH - Young Adult MH - Body Satisfaction MH - Motivation MH - Exercise/psychology MH - Factor Analysis, Statistical MH - Lithuania MH - Body Dissatisfaction/psychology MH - Surveys and Questionnaires MH - Sports/psychology PMC - PMC13666705 OTO - NOTNLM OT - adolescent girls OT - body image OT - disordered eating OT - fit ideal internalization OT - measurement invariance OT - psychometric validation OT - sports COIS- The authors report no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/10/01 CRDT- 2026/10/16 01:10 PHST- 2026/09/01 00:00 [received] PHST- 2026/09/24 00:00 [revised] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - nu18193248 [pii] AID - nutrients-18-03248 [pii] AID - 10.3390/nu18193248 [doi] PST - epublish SO - Nutrients. 2026 Oct 1;18(19):3248. doi: 10.3390/nu18193248. PMID- 42884672 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 29 TI - Beyond Self-Reported Adherence and Serology: Stool Gluten Immunogenic Peptides Detection to Assess Gluten Exposure in Children with Celiac Disease on a Gluten-Free Diet. LID - 10.3390/nu18193221 [doi] LID - 3221 AB - Background/Objectives: A lifelong gluten-free diet (GFD) is the only treatment for celiac disease (CD). However, current methods for monitoring GFD adherence do not accurately assess gluten exposure. Stool detection of gluten immunogenic peptides (GIP) may provide an objective tool for detecting recent gluten exposure. The aim of this study was to evaluate stool GIP detection, compared with serology and the validated Biagi dietary questionnaire, for monitoring GFD adherence in children with CD. Methods: In this prospective multicenter study, pediatric patients with CD on a GFD for at least 1 year were enrolled. Serum and stool samples were collected on the same day to assess serum anti-transglutaminase (TTG) and anti-endomysium (EMA) antibodies and stool GIP. Patients also completed the Biagi dietary questionnaire. Results: Forty-one pediatric patients with CD on a GFD for a median of 6.5 years were enrolled. Serum TTG and/or EMA were positive in 8/41 patients (19.5%), Biagi questionnaire identified 8/41 patients (19.5%) as non-adherent, whereas stool GIP was positive in 17/41 (41.5%). Combining serology with the dietary questionnaire increased the proportion of non-adherent patients to 34%. Adding stool GIP detection increased this proportion to 51% and 46% when combined with serology or the dietary questionnaire, respectively. Overall, 23/41 patients (56%) showed evidence of gluten exposure when positivity in at least one of the three methods was considered. Conclusions: A high rate of recent gluten exposure was detected in children with CD on a long-term GFD. Stool GIP detection may provide complementary information to conventional methods for monitoring GFD adherence and may help identify patients requiring further dietary assessment or intervention. FAU - Ziberna, Fabiana AU - Ziberna F AUID- ORCID: 0000-0002-9748-902X AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. FAU - Fontana, Giorgia AU - Fontana G AUID- ORCID: 0000-0001-7268-4104 AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. FAU - Zanchi, Chiara AU - Zanchi C AUID- ORCID: 0000-0001-8513-1963 AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. FAU - Bobbo, Marco AU - Bobbo M AD - Department of Pediatrics, University of Trieste, 34127 Trieste, Italy. FAU - Spinelli, Elena AU - Spinelli E AUID- ORCID: 0009-0008-6102-2250 AD - Department of Medical and Surgical Sciences, University of Trieste, 34127 Trieste, Italy. FAU - Grimaldi, Maria Cristina AU - Grimaldi MC AUID- ORCID: 0000-0002-4646-0032 AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. FAU - Tizi, Fatima AU - Tizi F AUID- ORCID: 0009-0009-8001-3314 AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. FAU - Di Leo, Grazia AU - Di Leo G AUID- ORCID: 0000-0002-6313-4482 AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. FAU - Martelossi, Stefano AU - Martelossi S AD - Ca' Foncello Hospital, 31100 Treviso, Italy. FAU - Not, Tarcisio AU - Not T AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. FAU - De Leo, Luigina AU - De Leo L AUID- ORCID: 0000-0003-4013-1630 AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. LA - eng GR - RC11/19/Ministry of Health/ PT - Journal Article PT - Multicenter Study DEP - 20260929 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 8002-80-0 (Glutens) RN - 0 (Peptides) RN - 0 (Autoantibodies) SB - IM MH - Humans MH - *Celiac Disease/diet therapy/immunology/blood MH - *Diet, Gluten-Free MH - Child MH - Female MH - *Glutens/immunology/analysis MH - *Feces/chemistry MH - Male MH - Prospective Studies MH - *Patient Compliance MH - Adolescent MH - Child, Preschool MH - *Peptides/analysis/immunology MH - Self Report MH - Surveys and Questionnaires MH - Autoantibodies/blood PMC - PMC13667095 OTO - NOTNLM OT - Biagi questionnaire OT - celiac disease OT - gluten immunogenic peptides OT - gluten-free diet COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/29 CRDT- 2026/10/16 01:10 PHST- 2026/09/08 00:00 [received] PHST- 2026/09/28 00:00 [revised] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - nu18193221 [pii] AID - nutrients-18-03221 [pii] AID - 10.3390/nu18193221 [doi] PST - epublish SO - Nutrients. 2026 Sep 29;18(19):3221. doi: 10.3390/nu18193221. PMID- 42884617 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 25 TI - Evaluation of a Wearable Hydration Monitor for Estimating Sweat Loss and Hydration Status in Collegiate Athletes: A Pilot Study. LID - 10.3390/nu18193166 [doi] LID - 3166 AB - BACKGROUND/OBJECTIVE: Instantaneous, accurate assessment of hydration and sweat loss has potential to optimize athlete performance and reduce risks associated with excessive exercise-related fluid loss. Reusable wearable hydration monitors, such as hDrop monitors, are an emerging non-invasive, quick, and easy to use alternative to existing methods. PURPOSE: To assess the accuracy of the hDrop wearable sweat monitors for estimating sweat loss and hydration status compared to established field-based measures, including body mass change and urine indices. METHODS: Division I male collegiate soccer athletes contributed repeated training-session observations (38 total observations; 18 complete observations for sweat-loss analyses and 36 for hydration-score-USG analyses). They completed training sessions during which pre- and post-exercise body mass, fluid intake, urine output, and urine samples were collected. Sweat loss was calculated using changes in body mass adjusted for fluid balance. hDrop-derived estimates of sweat loss and hydration status were compared to criterion measures using mean bias, percent of criterion, mean absolute percent error (MAPE), repeated-measures Bland-Altman analysis, and generalized estimating equations accounting for observations clustered within athletes. Associations between hydration scores and urine-based markers were assessed using generalized estimating equations accounting for observations clustered within athletes. RESULTS: The hDrop generated a sweat-loss estimate for 18 of 38 training-session observations (47.4%). Repeated-measures mean bias for sweat loss was -0.423 L (95% CI -1.106 to 0.259 L). The hDrop estimates averaged 106.2 +/- 64.8% of criterion while MAPE was 50.3%, reflecting large individual error. In the repeated-measures analysis, criterion-measured sweat loss was positively associated with hDrop-estimated sweat loss (B = 0.204, 95% CI 0.018 to 0.391, p = 0.032). Significant proportional bias was present (slope = -0.790, 95% CI -1.438 to -0.143, p = 0.020), indicating greater underestimation at higher sweat-loss values. In repeated-measures GEE analyses, USG was not significantly associated with the hDrop hydration score either before practice (B = -407.9, 95% CI -1008.7 to 192.8, p = 0.183) or after practice (B = -135.0, 95% CI -803.8 to 533.7, p = 0.692). CONCLUSIONS: The hDrop generated sweat-loss estimates in fewer than half of training-session observations and demonstrated substantial individual-level error and significant proportional bias when estimates were available. Although the instantaneous hydration score decreased following exercise, its lack of association with USG leaves its physiological meaning and criterion validity uncertain. These findings do not support use of the hDrop as an interchangeable substitute for established methods of individualized sweat-loss or hydration assessment. FAU - Snyder, Jill McCann AU - Snyder JM AUID- ORCID: 0009-0000-4031-3763 AD - Department of Nutrition and Dietetics, Brooks College of Health, University of North Florida, Jacksonville, FL 32224, USA. FAU - Toth, Lindsay AU - Toth L AUID- ORCID: 0000-0001-5856-2012 AD - Department of Clinical and Applied Movement Sciences, Brooks College of Health, University of North Florida, Jacksonville, FL 32224, USA. FAU - Aguero, Elysse AU - Aguero E AD - Department of Nutrition and Dietetics, Brooks College of Health, University of North Florida, Jacksonville, FL 32224, USA. FAU - Brennan, Colleen AU - Brennan C AD - Department of Nutrition and Dietetics, Brooks College of Health, University of North Florida, Jacksonville, FL 32224, USA. FAU - Duarte, Kassandra AU - Duarte K AD - Department of Nutrition and Dietetics, Brooks College of Health, University of North Florida, Jacksonville, FL 32224, USA. LA - eng GR - Brooks College of Health Pilot Research Grant/ PT - Journal Article DEP - 20260925 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Pilot Projects MH - *Wearable Electronic Devices MH - *Athletes MH - *Sweating/physiology MH - Young Adult MH - *Organism Hydration Status MH - *Dehydration/diagnosis MH - Water-Electrolyte Balance MH - Sweat MH - Monitoring, Physiologic/instrumentation MH - Adolescent MH - Drinking MH - Reproducibility of Results MH - Soccer MH - Exercise/physiology PMC - PMC13666982 OTO - NOTNLM OT - hydration assessment OT - sweat loss OT - validity COIS- hDrop Technologies Inc. donated the wearable monitors used in this study. The company had no role in the study design; collection, analysis, or interpretation of the data; preparation of the manuscript; or decision to submit the manuscript for publication. hDrop Technologies Inc. did not have access to the raw study data before manuscript preparation or submission. The authors declare no other conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/25 CRDT- 2026/10/16 01:10 PHST- 2026/08/04 00:00 [received] PHST- 2026/09/19 00:00 [revised] PHST- 2026/09/23 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - nu18193166 [pii] AID - nutrients-18-03166 [pii] AID - 10.3390/nu18193166 [doi] PST - epublish SO - Nutrients. 2026 Sep 25;18(19):3166. doi: 10.3390/nu18193166. PMID- 42884589 OWN - NLM STAT- MEDLINE DCOM- 20261019 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 23 TI - The Gut-Skin Axis in Pediatric Atopic Dermatitis: Nutritional Modulation, Microbiome Interactions, and Emerging Precision Approaches. LID - 10.3390/nu18193138 [doi] LID - 3138 AB - BACKGROUND/OBJECTIVES: Pediatric atopic dermatitis (AD) is a barrier-driven inflammatory skin disease with systemic immune and microbial correlates. The gut-skin axis offers a biologically plausible framework through which early-life nutrition, gut microbial metabolism, intestinal barrier function, and immune maturation may influence disease risk and expression, but much of the supporting evidence remains associative. This narrative review asks which nutritional strategies are supported by clinical evidence in children with AD, which remain investigational, and how far the field is from precision nutrition. METHODS: PubMed/MEDLINE, Scopus, and Web of Science were searched up to 31 July 2026; guidelines, systematic reviews, randomized trials, birth cohorts, and mechanistic studies with pediatric relevance were prioritized and appraised narratively. RESULTS: Breastfeeding when possible, dietary diversity during complementary feeding, avoidance of unnecessary elimination diets, correction of documented nutritional deficiencies, and management of confirmed food allergy are supported by current guidance. Probiotics and synbiotics lower SCORAD in meta-analyses, but the pooled effect is small, heterogeneous, and below the minimal clinically important difference, so they are best described as an optional adjunct rather than a recommended treatment; Mediterranean-style or high-fiber dietary patterns are backed mainly by observational data. Microbiome profiling, metabolomics, multi-omics endotyping, and artificial intelligence remain research tools without validated predictive value for dietary responses. CONCLUSIONS: Nutrition is an adjunct to, not a substitute for, established topical and systemic therapy in pediatric AD. Precision nutrition is a promising research direction rather than an established component of routine care, and its clinical value will depend on standardized biomarkers and well-designed longitudinal and interventional studies. FAU - Miulescu, Raluca-Gabriela AU - Miulescu RG AD - Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania. AD - Saint Constantin Hospital, 500388 Brasov, Romania. FAU - Costescu, Mihnea AU - Costescu M AUID- ORCID: 0000-0002-3678-7584 AD - Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania. FAU - Marin, Ruxandra-Cristina AU - Marin RC AUID- ORCID: 0000-0002-3182-1683 AD - Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania. FAU - Musetescu, Alina AU - Musetescu A AD - Department of Dermatology, "Dr. Victor Babes" Clinical Hospital of Infectious and Tropical Diseases, 030303 Bucharest, Romania. AD - Department of Dermatology, "Titu Maiorescu" University, 031593 Bucharest, Romania. FAU - Muntean, Calin AU - Muntean C AUID- ORCID: 0000-0002-0497-0405 AD - Department III Functional Science, Discipline of Medical Informatics and Biostatistics, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania. FAU - Rosca, Ioana AU - Rosca I AUID- ORCID: 0009-0002-4629-5820 AD - Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania. AD - Pediatrics Department, National Institute for Mother and Child Health "Alessandrescu-Rusescu", 20382 Bucharest, Romania. FAU - Adam, Iris-Iuliana AU - Adam II AD - Saint Constantin Hospital, 500388 Brasov, Romania. FAU - Ilici, Alina AU - Ilici A AD - Adeomed Clinic, 061344 Bucharest, Romania. FAU - Coman, Oana Andreia AU - Coman OA AD - Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania. LA - eng PT - Journal Article PT - Review DEP - 20260923 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - *Gastrointestinal Microbiome/physiology MH - *Skin/microbiology MH - *Dermatitis, Atopic/complications/microbiology/therapy MH - Intestinal Barrier Function MH - *Child Nutritional Physiological Phenomena/physiology MH - *Precision Medicine/methods MH - Probiotics/administration & dosage MH - Diet MH - Dysbiosis/complications/microbiology/therapy MH - Humans MH - Child PMC - PMC13667208 OTO - NOTNLM OT - biomarkers OT - gut microbiome OT - gut-skin axis OT - microbial metabolites OT - nutrition OT - pediatric atopic dermatitis OT - precision nutrition OT - probiotics COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/23 CRDT- 2026/10/16 01:10 PHST- 2026/08/23 00:00 [received] PHST- 2026/09/17 00:00 [revised] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - nu18193138 [pii] AID - nutrients-18-03138 [pii] AID - 10.3390/nu18193138 [doi] PST - epublish SO - Nutrients. 2026 Sep 23;18(19):3138. doi: 10.3390/nu18193138. PMID- 42884588 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 23 TI - Host-Microbiota Interactions in Adolescents with Severe Anorexia Nervosa: Linking Gut Dysbiosis, Intestinal Barrier Function and Microbial Metabolism. LID - 10.3390/nu18193136 [doi] LID - 3136 AB - BACKGROUND: Anorexia nervosa (AN) is increasingly recognized as a multisystem disorder involving complex host-microbiota interactions, yet prospective pediatric studies with a comprehensive, longitudinal characterization of host-microbiota interactions remain scarce. METHODS: In this prospective longitudinal study, 26 adolescents with severe AN were evaluated at hospital admission (T0), after one month (T1), and after three months of inpatient nutritional rehabilitation (T2). Gut microbiota composition was assessed by 16S rRNA sequencing and compared with healthy controls (HC) at the baseline; predicted functional profiling was performed using PICRUSt2. Serum and urinary biomarkers of intestinal barrier integrity and microbial metabolism, routine clinical and biochemical parameters, and psychometric scores (CDI-2, MASC-2) were evaluated longitudinally using linear mixed-effects models. RESULTS: At the baseline, adolescents with AN showed reduced bacterial richness compared with healthy controls, with significantly lower Chao1 diversity (p = 0.00013), whereas the Shannon and Simpson indices did not differ significantly (p = 0.54 and p = 0.27, respectively). Microbial community composition differed significantly between groups based on Bray-Curtis (R(2) = 0.0724, FDR-adjusted p = 0.001) and unweighted UniFrac (R(2) = 0.0540, FDR-adjusted p = 0.001) distances. LEfSe identified 19 differentially abundant taxa; among the strongest discriminators, Blautia_A_141781, Romboutsia_B, and Clostridium_T were enriched in AN, whereas Akkermansia, Phocaeicola_A_858004, and Bacteroides_H were enriched in the healthy controls. Nutritional rehabilitation was associated with partial microbiota remodeling, alongside significant improvements in BMI and heart rate. Several host-derived biomarkers, including urinary indican, serotonin, nitric oxide, and serum occludin, changed significantly over time, whereas bile acids, short-chain fatty acids, IgA, lipopolysaccharide, and haptoglobin remained stable. CONCLUSIONS: Gut microbiota and host-derived biomarkers evolve dynamically during nutritional rehabilitation in adolescents with severe AN, supporting their potential role as complementary tools for monitoring biological recovery. FAU - Gargiullo, Livia AU - Gargiullo L AUID- ORCID: 0000-0003-0316-6359 AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Del Chierico, Federica AU - Del Chierico F AUID- ORCID: 0000-0002-4204-4736 AD - Unit of Microbiome, Bambino Gesu Children's Hospital, IRCCS, 00146 Rome, Italy. FAU - Marchili, Maria Rosaria AU - Marchili MR AUID- ORCID: 0000-0002-6787-8198 AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Irrera, Mariangela AU - Irrera M AUID- ORCID: 0009-0002-3274-9756 AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Pretelli, Italo AU - Pretelli I AD - Anorexia and Eating Disorders Unit, Child and Adolescent Psychiatry, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Scanu, Matteo AU - Scanu M AUID- ORCID: 0000-0001-6266-2884 AD - Unit of Microbiome, Bambino Gesu Children's Hospital, IRCCS, 00146 Rome, Italy. FAU - Toto, Francesca AU - Toto F AD - Unit of Microbiome, Bambino Gesu Children's Hospital, IRCCS, 00146 Rome, Italy. FAU - Grandin, Annalisa AU - Grandin A AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Marotta, Rosaria AU - Marotta R AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Mascolo, Cristina AU - Mascolo C AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Cirillo, Flavia AU - Cirillo F AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Colistra, Valentina AU - Colistra V AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Ricci, Ludovica AU - Ricci L AD - Pediatrics Residency Program, Department of Pediatrics, University of Rome Tor Vergata, 00133 Rome, Italy. FAU - Zanna, Valeria AU - Zanna V AD - Anorexia and Eating Disorders Unit, Child and Adolescent Psychiatry, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Putignani, Lorenza AU - Putignani L AUID- ORCID: 0000-0003-0134-2830 AD - Department of Life Sciences, Health and Health Professions, Link Campus University, 00165 Rome, Italy. AD - Unit of Microbiomics and Unit of Microbiome, Bambino Gesu Children's Hospital, IRCCS, 00146 Rome, Italy. FAU - Villani, Alberto AU - Villani A AUID- ORCID: 0000-0002-9120-0424 AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. AD - Systems Medicine Departments, University of Rome Tor Vergata, 00133 Rome, Italy. LA - eng GR - RC2025_IMMUNO_GARGIULLO, RC2025_INNOV_DELCHIERICO/Ministry of Health/ PT - Journal Article DEP - 20260923 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) RN - 0 (RNA, Ribosomal, 16S) SB - IM MH - Humans MH - *Anorexia Nervosa/microbiology MH - Adolescent MH - Female MH - Intestinal Barrier Function MH - *Dysbiosis/microbiology MH - Prospective Studies MH - *Gastrointestinal Microbiome/physiology MH - Longitudinal Studies MH - Biomarkers/blood/urine MH - RNA, Ribosomal, 16S MH - Bacteria/classification/metabolism MH - Male PMC - PMC13666687 OTO - NOTNLM OT - anorexia nervosa OT - biomarkers OT - gut microbiota OT - gut-brain axis OT - intestinal permeability OT - nutritional rehabilitation COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/23 CRDT- 2026/10/16 01:10 PHST- 2026/08/13 00:00 [received] PHST- 2026/09/17 00:00 [revised] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - nu18193136 [pii] AID - nutrients-18-03136 [pii] AID - 10.3390/nu18193136 [doi] PST - epublish SO - Nutrients. 2026 Sep 23;18(19):3136. doi: 10.3390/nu18193136. PMID- 42884577 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 23 TI - Dietary and Fluid-Intake Habits in Patients with Various Types of Urinary Incontinence: A Preliminary Study. LID - 10.3390/nu18193127 [doi] LID - 3127 AB - Background/Objectives: Urinary incontinence (UI) is common in women, particularly during and after the menopausal transition, and may both influence and be influenced by dietary and fluid-intake behaviours. This exploratory study described self-reported dietary and fluid-intake habits in women with different UI subtypes and explored their associations with pelvic floor symptom burden and self-reported fluid restriction. Energy and nutrient intake was not quantified. Methods: This exploratory, cross-sectional, single-centre study included 87 women aged 18-84 years with stress (SUI; n = 23), urgency (UUI; n = 21), or mixed (MUI; n = 43) UI, who reported UI at least weekly. Participants completed a custom dietary and fluid-intake questionnaire, the Incontinence Quality of Life Questionnaire (I-QOL), and the Pelvic Floor Distress Inventory-20 (PFDI-20). Associations were assessed using rank correlations and proportional-odds ordinal logistic regression, with Benjamini-Hochberg correction used to address multiplicity in exploratory item-level analyses. Results: No individual diet-PFDI association remained statistically significant after Benjamini-Hochberg correction across the complete 100-test matrix. In the adjusted model, an urgency component was associated with greater self-reported fluid restriction (adjusted cumulative OR = 2.92; 95% CI, 1.18-7.20), whereas each 10-year increase in age was associated with lower odds of greater restriction (adjusted cumulative OR = 0.68; 95% CI, 0.51-0.92). Conclusions: Greater self-reported fluid restriction was independently associated with an urgency component and with younger age, whereas no individual dietary or fluid-intake item remained statistically significant after correction for multiple comparisons. Given the potential risk of the practice, these findings support asking women with urgency symptoms about fluid restriction during clinical consultations. Prospective studies using a validated quantitative dietary instrument are needed to determine whether dietary and fluid-intake habits affect pelvic floor symptom burden. FAU - Piatek, Aleksandra AU - Piatek A AUID- ORCID: 0000-0002-5887-817X AD - Department of Gynecology, Independent Public Health Care Center of the Ministry of the Interior and Administration in Wroclaw, 50-233 Wroclaw, Poland. FAU - Kolodynska, Gabriela AU - Kolodynska G AUID- ORCID: 0000-0001-7921-7058 AD - Faculty of Physiotherapy, Wroclaw University of Health and Sport Sciences, 51-612 Wroclaw, Poland. FAU - Nowak, Krzysztof AU - Nowak K AUID- ORCID: 0000-0002-2230-9012 AD - Department of Gynecology, Independent Public Health Care Center of the Ministry of the Interior and Administration in Wroclaw, 50-233 Wroclaw, Poland. FAU - Drapala, Jaroslaw AU - Drapala J AUID- ORCID: 0000-0002-7251-9595 AD - Faculty of Information and Communication Technology, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland. FAU - Fink-Lwow, Felicja AU - Fink-Lwow F AUID- ORCID: 0000-0002-4323-7134 AD - Faculty of Physiotherapy, Wroclaw University of Health and Sport Sciences, 51-612 Wroclaw, Poland. FAU - Andrzejewski, Waldemar AU - Andrzejewski W AUID- ORCID: 0000-0002-0010-3021 AD - Faculty of Physiotherapy, Wroclaw University of Health and Sport Sciences, 51-612 Wroclaw, Poland. FAU - Zalewski, Maciej AU - Zalewski M AUID- ORCID: 0000-0002-0924-6870 AD - Department of Gynecology, Independent Public Health Care Center of the Ministry of the Interior and Administration in Wroclaw, 50-233 Wroclaw, Poland. LA - eng PT - Journal Article DEP - 20260923 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Middle Aged MH - Aged MH - Adult MH - Cross-Sectional Studies MH - Aged, 80 and over MH - Adolescent MH - Young Adult MH - Quality of Life MH - *Diet MH - *Urinary Incontinence/physiopathology MH - Surveys and Questionnaires MH - *Feeding Behavior MH - *Drinking MH - *Drinking Behavior MH - Urinary Incontinence, Stress PMC - PMC13666888 OTO - NOTNLM OT - PFDI-20 OT - dietary habits OT - fluid intake OT - nutrition OT - overactive bladder OT - urinary incontinence COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/23 CRDT- 2026/10/16 01:10 PHST- 2026/07/20 00:00 [received] PHST- 2026/09/16 00:00 [revised] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - nu18193127 [pii] AID - nutrients-18-03127 [pii] AID - 10.3390/nu18193127 [doi] PST - epublish SO - Nutrients. 2026 Sep 23;18(19):3127. doi: 10.3390/nu18193127. PMID- 42883820 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 27 IP - 19 DP - 2026 Sep 25 TI - Maternal Gestational Hypertension Is Associated with Reduced TSG-6 in Human Milk: Potential Implications for Neonatal Immunological Support. LID - 10.3390/ijms27198573 [doi] LID - 8573 AB - Tumor necrosis factor alpha-stimulated protein 6 (TSG-6) is a potent anti-inflammatory mediator secreted by mesenchymal stem cells (MSCs). In human milk (HM), these cells (human milk mesenchymal stem cells, HM-MSCs) contribute to postnatal programming of the neonatal gastrointestinal immune axis. This study assessed how maternal gestational hypertension and maternal age affect the cytoprotective TSG-6 pool and its associated immunomodulatory microRNA signature in early milk. Early colostrum, 2-4 days postpartum, from healthy mothers and hypertensive patients was analyzed. TSG-6 gene expression in the heterogeneous milk cellular fraction containing HM-MSCs and TSG-6 protein concentration in whole milk were determined using quantitative polymerase chain reaction (qPCR) and Enzyme-Linked Immunosorbent Assay (ELISA), respectively. Comprehensive multivariable General Linear Models (GLMs) were used to adjust for potential confounding variables, including pre-pregnancy Body Mass Index (BMI), gestational age (GA), and gestational diabetes. Additionally, TSG-6 levels were correlated with fetal cord blood gas parameters and previously profiled microRNAs in the cellular fraction. GLM analysis revealed that gestational hypertension remained significantly associated with reduced TSG-6 gene expression in the cellular fraction and total TSG-6 protein concentration in whole milk, regardless of pre-pregnancy BMI or metabolic comorbidities. In healthy pregnancies, exploratory analyses suggested that TSG-6 levels correlated positively with optimal fetal metabolic status (cord blood pH). Importantly, TSG-6 expression showed a strong positive correlation with a signature of immunomodulatory microRNAs (miR) (miR-155-5p, miR-21-3p, miR-126-3p). These microRNAs were concurrently downregulated in the hypertensive group; however, because all hypertensive participants received methyldopa, the independent contributions of hypertension and antihypertensive treatment to these changes cannot be distinguished. Gestational hypertension independently reduces the anti-inflammatory TSG-6 in early breast milk. The concomitant reduction in TSG-6 and its correlated microRNA co-expression pattern indicates an altered immunomodulatory profile within the mammary gland during lactation. We hypothesize that these changes might alter the local immunomodulatory properties of milk in the neonatal gastrointestinal tract. However, because no functional in vitro or in vivo assays were performed, this remains a purely theoretical implication that requires future experimental validation. FAU - Przywara, Dominika AU - Przywara D AUID- ORCID: 0000-0002-6143-9653 AD - Department of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland. AD - Doctoral School, Medical University of Lublin, 20-093 Lublin, Poland. FAU - Kondracka, Adrianna AU - Kondracka A AD - Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 11 Staszica Str., 20-081 Lublin, Poland. FAU - Petniak, Alicja AU - Petniak A AUID- ORCID: 0000-0001-9926-0870 AD - Department of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland. FAU - Slyk-Gulewska, Patrycja AU - Slyk-Gulewska P AUID- ORCID: 0009-0008-6201-6514 AD - Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 11 Staszica Str., 20-081 Lublin, Poland. FAU - Drag, Magdalena AU - Drag M AUID- ORCID: 0000-0002-9351-8997 AD - Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 11 Staszica Str., 20-081 Lublin, Poland. FAU - Szymanowska, Urszula AU - Szymanowska U AUID- ORCID: 0000-0001-9692-2111 AD - Department of Biochemistry and Food Chemistry, University of Life Sciences, 8 Skromna Str., 20-704 Lublin, Poland. FAU - Czuba, Monika AU - Czuba M AD - Department of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland. FAU - Jaremek, Milena AU - Jaremek M AUID- ORCID: 0000-0002-9504-2216 AD - Department of Invertebrate Ecophysiology and Experimental Biology, Faculty of Environmental Biology, University of Life Sciences in Lublin, 54 Doswiadczalna Street, 20-280 Lublin, Poland. FAU - Strachecka, Aneta AU - Strachecka A AD - Department of Invertebrate Ecophysiology and Experimental Biology, Faculty of Environmental Biology, University of Life Sciences in Lublin, 54 Doswiadczalna Street, 20-280 Lublin, Poland. FAU - Kocki, Janusz AU - Kocki J AUID- ORCID: 0000-0002-9541-6353 AD - Department of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland. FAU - Gil-Kulik, Paulina AU - Gil-Kulik P AUID- ORCID: 0000-0003-3119-981X AD - Department of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland. LA - eng GR - Grant nr: INT/006/2025/IV-N)./Union of Lublin Universities/ PT - Journal Article DEP - 20260925 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - 0 (TNFAIP6 protein, human) RN - 0 (Cell Adhesion Molecules) RN - 0 (MicroRNAs) SB - IM MH - Humans MH - Female MH - *Cell Adhesion Molecules/metabolism/genetics MH - Pregnancy MH - *Hypertension, Pregnancy-Induced/metabolism/immunology/genetics MH - *Milk, Human/metabolism/immunology MH - MicroRNAs/genetics/metabolism MH - Adult MH - Infant, Newborn MH - Mesenchymal Stem Cells/metabolism PMC - PMC13665462 OTO - NOTNLM OT - HM-MSCs OT - TSG-6 OT - fetal metabolic status OT - gestational hypertension OT - human milk mesenchymal stem cells OT - microRNA COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/25 CRDT- 2026/10/16 01:07 PHST- 2026/08/27 00:00 [received] PHST- 2026/09/20 00:00 [revised] PHST- 2026/09/24 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:07 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - ijms27198573 [pii] AID - ijms-27-08573 [pii] AID - 10.3390/ijms27198573 [doi] PST - epublish SO - Int J Mol Sci. 2026 Sep 25;27(19):8573. doi: 10.3390/ijms27198573. PMID- 42882043 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261016 LR - 20261020 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 19 DP - 2026 Sep 29 TI - Continuous Glucose Monitoring for Women with Gestational Diabetes, CORDELIA: A Multicentric Randomized Controlled Trial, Methodology and Design. LID - 10.3390/jcm15197581 [doi] LID - 7581 AB - Background/Objectives: Gestational diabetes mellitus (GDM) is associated with increased short- and long-term risks for both mother and child. Screening and treatment between 24 and 30 weeks' gestation reduces adverse pregnancy outcomes, while emerging evidence suggests that earlier diagnosis and treatment (<20 weeks') in high-risk populations may further improve neonatal outcomes. Currently, self-monitoring of blood glucose (SMBG) remains the standard of care for management but provides only intermittent glycemic data and limited insight into overall glucose patterns. Real-time continuous glucose monitoring (rt-CGM) has transformed management in pregnancies complicated by type 1 diabetes but has shown conflicting results in GDM; it is thus unclear whether similar benefits may extend to women with GDM, including women with early GDM. Methods: The Continuous Glucose Monitoring for Women With Gestational Diabetes (CORDELIA) study is an ongoing, large, open-label, multicenter randomized controlled trial conducted across 14 centers in Belgium and two centers in Australia. Women diagnosed with GDM are randomized in a 1:1 ratio to either rt-CGM (intervention group) or standard care with SMBG (control group). Both women with early GDM diagnosed before 20 weeks' gestation and those diagnosed between 24.0 and 29.6 weeks' gestation are included. Participants attend the following visits: baseline visit at GDM diagnosis, an additional visit at 20.0-23.9 weeks' (if early GDM), 31.0-33.6 weeks' and 36.0-38.6 weeks', and a postpartum oral glucose tolerance test (OGTT) assessment (6.0-23.6 weeks after delivery). At each visit, clinical assessment, HbA1c, and (blinded) CGM are evaluated, alongside validated patient-reported outcome questionnaires. The primary objective is to compare the incidence of a composite of adverse pregnancy outcomes between the rt-CGM and SMBG groups. The primary outcome is a composite of adverse pregnancy outcomes including preterm delivery <37 weeks, LGA [customized percentiles according to Gestation Related Optimal Weight chart (GROW)], neonatal hypoglycemia requiring intravenous dextrose, neonatal intensive care unit (NICU) admission > 24 h, neonatal respiratory distress, stillbirth or neonatal death, phototherapy, birth trauma, and shoulder dystocia. Secondary outcomes include maternal glycemia, insulin use, pregnancy and neonatal outcomes, glycemic variability, patient-reported outcomes, and prespecified secondary analyses according to timing of GDM diagnosis and maternal BMI. Trial Registration: ClinicalTrials.gov: NCT06310356. First posted: 15 March 2024. FAU - Geerts, Ina AU - Geerts I AUID- ORCID: 0009-0004-2803-7013 AD - Department of Chronic Diseases and Metabolism, Clinical and Experimental Endocrinology, KU Leuven, 3000 Leuven, Belgium. FAU - Yu, Catherine AU - Yu C AUID- ORCID: 0009-0005-7013-8640 AD - Department of Chronic Diseases and Metabolism, Clinical and Experimental Endocrinology, KU Leuven, 3000 Leuven, Belgium. FAU - Bochanen, Niels AU - Bochanen N AUID- ORCID: 0000-0002-1265-9086 AD - Department of Endocrinology-Diabetology-Metabolism, Antwerp University Hospital, 2650 Edegem, Belgium. FAU - Heyns, Ellen AU - Heyns E AD - Department of Endocrinology, General Hospital Groeninge Kortrijk, 8500 Kortrijk, Belgium. FAU - Pottelbergh, Inge Van AU - Pottelbergh IV AD - Department of Endocrinology, AZORG Aalst, 9300 Aalst, Belgium. FAU - Morrens, Astrid AU - Morrens A AD - Department of Endocrinology, ZAS Palfijn, 2170 Merksem, Belgium. FAU - Coremans, Peter AU - Coremans P AD - Department of Endocrinology-Diabetology, Vitaz, 9100 Sint-Niklaas, Belgium. FAU - Philips, Jean-Christophe AU - Philips JC AD - Department of Diabetology, Nutrition and Metabolic Diseases, CHU de Liege, 4000 Liege, Belgium. FAU - Carton, Tiphaine AU - Carton T AD - Department of Endocrinology, Erasme Hospital, 1070 Brussels, Belgium. FAU - Vandewalle, Sara AU - Vandewalle S AUID- ORCID: 0000-0001-8422-4973 AD - Department of Endocrinology-Diabetology, AZ Sint-Jan Brugge, 8000 Brugge, Belgium. FAU - Marlier, Joke AU - Marlier J AUID- ORCID: 0000-0002-9500-608X AD - Department of Endocrinology, UZ Gent, 9000 Gent, Belgium. FAU - Van Boxelaer, Inge AU - Van Boxelaer I AUID- ORCID: 0009-0000-0009-9598 AD - Department of Endocrinology, AZ Sint Lucas Gent, 9000 Gent, Belgium. FAU - Winne, Linsey AU - Winne L AD - Department of Endocrinology, AZ Oostende, 8400 Oostende, Belgium. FAU - Bollaerts, Kathleen AU - Bollaerts K AD - Department of Endocrinology, AZ Sint Maarten Mechelen, 2800 Mechelen, Belgium. FAU - Lee, Dahae AU - Lee D AD - Department of Endocrinology, Imelda Bonheiden, 2820 Bonheiden, Belgium. FAU - Simmons, David AU - Simmons D AUID- ORCID: 0000-0003-0560-0761 AD - School of Medicine, Western Sydney University, Sydney, NSW 2560, Australia. FAU - Sweeting, Arianne AU - Sweeting A AUID- ORCID: 0000-0001-6843-6247 AD - Department of Endocrinology, Royal Prince Alfred Hospital and Charles Perkins Centre, University of Sydney, Sydney, NSW 2050, Australia. FAU - Laenen, Annouschka AU - Laenen A AUID- ORCID: 0000-0002-1371-442X AD - Leuven Biostatistics and Statistical Bioinformatics Centre, KU Leuven, 3000 Leuven, Belgium. FAU - Mathieu, Chantal AU - Mathieu C AD - Department of Chronic Diseases and Metabolism, Clinical and Experimental Endocrinology, KU Leuven, 3000 Leuven, Belgium. AD - Department of Endocrinology, University Hospitals Leuven, 3000 Leuven, Belgium. FAU - Benhalima, Katrien AU - Benhalima K AUID- ORCID: 0000-0002-3325-0263 AD - Department of Chronic Diseases and Metabolism, Clinical and Experimental Endocrinology, KU Leuven, 3000 Leuven, Belgium. AD - Department of Endocrinology, University Hospitals Leuven, 3000 Leuven, Belgium. LA - eng SI - ClinicalTrials.gov/NCT06310356 GR - Abbott Diabetes Care/ GR - LifeScan/ GR - Research Foundation - Flanders/ PT - Journal Article DEP - 20260929 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13665732 OTO - NOTNLM OT - continuous glucose monitoring OT - early gestational diabetes OT - gestational diabetes mellitus OT - pregnancy outcomes COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/29 CRDT- 2026/10/16 01:01 PHST- 2026/07/10 00:00 [received] PHST- 2026/09/06 00:00 [revised] PHST- 2026/09/25 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:01 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - jcm15197581 [pii] AID - jcm-15-07581 [pii] AID - 10.3390/jcm15197581 [doi] PST - epublish SO - J Clin Med. 2026 Sep 29;15(19):7581. doi: 10.3390/jcm15197581. PMID- 42881772 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261016 LR - 20261020 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 19 DP - 2026 Oct 6 TI - Association of Halliwick-Based Aquatic Physical Activity with Health-Related Quality of Life in Children and Adolescents with Autism Spectrum Disorder: A Cross-Sectional Comparative Study. LID - 10.3390/healthcare14193323 [doi] LID - 3323 AB - BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by persistent deficits in social communication and interaction, accompanied by restricted and repetitive patterns of behavior, interests, or activities. Given the considerable heterogeneity in symptom severity and functional abilities, children with ASD require individualized educational and therapeutic interventions. Among the non-pharmacological approaches used to support this population, aquatic physical activity has emerged as a promising intervention. MATERIAL AND METHODS: The study included 45 children with ASD (ICD-11 code 6A02), comprising 19 girls and 26 boys, aged 8-17 years. Two groups were compared: Group G1, consisting of children and adolescents who had participated in Halliwick-based aquatic physical activity for at least 3 months, and Group G2, without aquatic activities. Health-related quality of life was assessed using the validated Polish version of the KIDSCREEN-52 questionnaire. RESULTS: Children with ASD who participated in Halliwick-based aquatic physical activity (G1) had higher mean scores in all KIDSCREEN-52 domains. However, statistically significant differences were only found in the following domains: Psychological Well-Being, Moods and Emotions, Self-Perception, Autonomy, Financial Resources, and School Environment. Overall health-related quality of life, measured by the KIDSCREEN-10, compared with children who did not participate in aquatic activities. CONCLUSIONS: Halliwick-based aquatic physical activity was associated with better quality of life in children and adolescents with ASD, with higher scores observed according to sex, but further research is needed to confirm these findings. FAU - Stefanska, Malgorzata AU - Stefanska M AUID- ORCID: 0000-0003-2070-8535 AD - Faculty of Physiotherapy, Wroclaw University of Health and Sport Science, al. Paderewskiego 35, 51-612 Wroclaw, Poland. FAU - Smetek, Wiktoria AU - Smetek W AD - Reh-Medica Marek Smiech, ul. Odrzanska 7, 47-224 Kedzierzyn-Kozle, Poland. FAU - Kowalska, Joanna AU - Kowalska J AUID- ORCID: 0000-0002-5232-1688 AD - Faculty of Physiotherapy, Wroclaw University of Health and Sport Science, al. Paderewskiego 35, 51-612 Wroclaw, Poland. FAU - Ptak, Agnieszka AU - Ptak A AUID- ORCID: 0000-0002-8396-5267 AD - Faculty of Physiotherapy, Wroclaw University of Health and Sport Science, al. Paderewskiego 35, 51-612 Wroclaw, Poland. LA - eng PT - Journal Article DEP - 20261006 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13665036 OTO - NOTNLM OT - Halliwick method OT - KIDSSCREEN OT - aquatic physical activity OT - autism spectrum disorders OT - physical activity OT - quality of life COIS- Author Wiktoria Smetek was employed by Reh-Medica Marek Smiech. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/16 05:32 MHDA- 2026/10/16 05:33 PMCR- 2026/10/06 CRDT- 2026/10/16 01:01 PHST- 2026/07/23 00:00 [received] PHST- 2026/09/12 00:00 [revised] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/16 05:33 [medline] PHST- 2026/10/16 05:32 [pubmed] PHST- 2026/10/16 01:01 [entrez] PHST- 2026/10/06 00:00 [pmc-release] AID - healthcare14193323 [pii] AID - healthcare-14-03323 [pii] AID - 10.3390/healthcare14193323 [doi] PST - epublish SO - Healthcare (Basel). 2026 Oct 6;14(19):3323. doi: 10.3390/healthcare14193323. PMID- 42881744 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261016 LR - 20261020 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 19 DP - 2026 Oct 3 TI - The Psychosocial Pathways of Expectancy-Value Beliefs, Physical Fitness, and Executive Function Among Adolescents. LID - 10.3390/healthcare14193305 [doi] LID - 3305 AB - Background/Objectives: Adequate physical fitness has been associated with cognitive health among adolescents, and psychosocial processes may help explain this relationship. However, evidence regarding the mechanisms linking physical fitness and cognitive health remains limited. Guided by expectancy-value theory, this study examined the direct and indirect effects of expectancy-value beliefs on executive function through physical fitness among adolescents. Methods: A prospective research design was used. Participants were 424 adolescents (58% female; Mage = 12.72 years, SD = 0.93) recruited from the southwestern United States. Physical fitness components, including cardiovascular fitness, muscular fitness, flexibility, and body mass index (BMI), were assessed using the FITNESSGRAM((R)) test battery. Expectancy-value beliefs and executive function were measured using validated self-report instruments. Structural equation modeling was conducted to examine the proposed relationships. Results: Expectancy-value beliefs were significantly associated with all physical fitness components (rs ranged from -0.86 to 0.46, ps < 0.01) except flexibility. Cardiovascular fitness and muscular fitness were negatively associated with executive function scores (rs ranged from -0.29 to -0.21, ps < 0.01), whereas BMI was positively associated with executive function scores. The proposed model demonstrated an acceptable fit (chi(2)/df = 284.16/113, p < 0.001; CFI = 0.90; RMSEA = 0.06, 90% CI [0.05, 0.07]). There was a significant indirect effect of expectancy-value beliefs on executive function through physical fitness (beta = -0.11). The model explained 12% of the variance in physical fitness and 9% of the variance in executive function. Conclusions: The findings provide evidence for the proposed psychosocial mediation model linking expectancy-value beliefs, physical fitness, and executive function among adolescents. It suggests strategies that strengthen perceived competence and task values may improve physical fitness and, in turn, enhance executive function. FAU - Shen, Dijun AU - Shen D AD - Department of Physical Education, Shanghai Lixin University Accounting and Finance, Shanghai 201620, China. FAU - Bao, Sarina AU - Bao S AD - Department of Earth and Planetary Science, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan. FAU - Zhang, Xiaoxia AU - Zhang X AUID- ORCID: 0000-0001-5076-9035 AD - School of Sport Sciences, West Virginia University, Morgantown, WV 26506-6116, USA. LA - eng PT - Journal Article DEP - 20261003 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13664947 OTO - NOTNLM OT - adolescents OT - cognitive health OT - executive function OT - expectancy-value beliefs OT - physical fitness OT - psychosocial mechanisms OT - structural equation modeling COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:32 MHDA- 2026/10/16 05:33 PMCR- 2026/10/03 CRDT- 2026/10/16 01:01 PHST- 2026/07/30 00:00 [received] PHST- 2026/09/22 00:00 [revised] PHST- 2026/09/30 00:00 [accepted] PHST- 2026/10/16 05:33 [medline] PHST- 2026/10/16 05:32 [pubmed] PHST- 2026/10/16 01:01 [entrez] PHST- 2026/10/03 00:00 [pmc-release] AID - healthcare14193305 [pii] AID - healthcare-14-03305 [pii] AID - 10.3390/healthcare14193305 [doi] PST - epublish SO - Healthcare (Basel). 2026 Oct 3;14(19):3305. doi: 10.3390/healthcare14193305. PMID- 42881645 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261016 LR - 20261020 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 19 DP - 2026 Sep 28 TI - Beyond Screen Time: A Scoping Review of Screen Exposure and Early Childhood Development. LID - 10.3390/healthcare14193206 [doi] LID - 3206 AB - BACKGROUND: Screen exposure in early childhood has evolved beyond traditional duration-focused "screen time" to encompass a multidimensional construct including content quality, context of use, co-viewing, caregiver mediation, and developmental trajectories. Understanding these dimensions is essential for comprehensive assessment, particularly in rapidly digitizing cultural contexts such as Saudi Arabia and the broader Middle East. OBJECTIVES: This scoping review aimed to systematically map and synthesize peer-reviewed evidence on multidimensional screen exposure and developmental outcomes in children aged 0-5 years, with specific focus on language, cognitive, and socio-emotional outcomes. METHODS: This scoping review followed PRISMA-ScR guidelines. Systematic searches were performed in PubMed, Scopus, Web of Science, and Google Scholar (2016-2026). Inclusion criteria were primary empirical studies (randomized trials and observational designs), children aged 0-5 years (up to 72 months, provided primary exposure was assessed within the 0-5-year window), quantitative screen exposure measurement, and validated developmental outcome assessment. Data were extracted and synthesized narratively across the developmental domains. RESULTS: Twenty-seven studies demonstrated that content quality, context of use, and caregiver behavior (including co-viewing and active guidance of screen use) consistently modified the strength of associations between screen exposure and early developmental outcomes. Language development was the most extensively studied domain; co-viewing emerged as a key protective factor, and longitudinal trajectory analyses identified heterogeneous exposure patterns with differing developmental implications across cognitive, socio-emotional, and physical domains. CONCLUSIONS: Screen exposure in early childhood is a multidimensional phenomenon requiring assessment tools that capture content, context, co-use, and caregiver mediation alongside duration. Findings highlight the need for culturally adapted measurement instruments in the Saudi Arabian context to support evidence-based early childhood practice and align with Vision 2030 objectives. FAU - Alghadier, Mshari AU - Alghadier M AUID- ORCID: 0000-0003-3686-8074 AD - Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Alkharj 11942, Saudi Arabia. FAU - Elnaggar, Ragab K AU - Elnaggar RK AUID- ORCID: 0000-0001-5080-702X AD - Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Alkharj 11942, Saudi Arabia. FAU - Ghandurah, Abdulaziz AU - Ghandurah A AUID- ORCID: 0009-0007-6732-7621 AD - Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Alkharj 11942, Saudi Arabia. AD - Rehabilitation Department, Ministry of the National Guard-Health Affairs, Riyadh 11426, Saudi Arabia. FAU - Alhisony, Nouf AU - Alhisony N AD - Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Alkharj 11942, Saudi Arabia. LA - eng GR - PSAU/2026/03/44759/Prince Sattam Bin Abdulaziz University/ PT - Journal Article PT - Review DEP - 20260928 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13664933 OTO - NOTNLM OT - Saudi Arabia OT - caregiver mediation OT - early childhood development OT - executive function OT - language development OT - scoping review OT - screen exposure OT - screen time COIS- The authors declare no conflict of interest. EDAT- 2026/10/16 05:32 MHDA- 2026/10/16 05:33 PMCR- 2026/09/28 CRDT- 2026/10/16 01:00 PHST- 2026/08/25 00:00 [received] PHST- 2026/09/20 00:00 [revised] PHST- 2026/09/25 00:00 [accepted] PHST- 2026/10/16 05:33 [medline] PHST- 2026/10/16 05:32 [pubmed] PHST- 2026/10/16 01:00 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - healthcare14193206 [pii] AID - healthcare-14-03206 [pii] AID - 10.3390/healthcare14193206 [doi] PST - epublish SO - Healthcare (Basel). 2026 Sep 28;14(19):3206. doi: 10.3390/healthcare14193206. PMID- 42881639 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261016 LR - 20261020 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 19 DP - 2026 Sep 28 TI - Risk Profile for Eating Behaviours and Body Perception in a Convenience Sample of Adults: Implications for Health Policy and Person-Centred Care in Primary Healthcare. LID - 10.3390/healthcare14193203 [doi] LID - 3203 AB - Background/Objectives: Person-centred care necessitates addressing the growing biopsychosocial vulnerability within public health. This study analysed eating behaviours and sociocultural pressures regarding physical appearance in a convenience sample of adults to help inform potential evidence-based policies and programmes in primary care tailored to these exploratory symptom correlates. Methods: A quantitative, observational, cross-sectional study was conducted with 1287 participants. Data were collected via an online platform using the Eating Attitudes Test (EAT-26) and the Sociocultural Attitudes Towards Appearance Questionnaire (SATAQ-4). Descriptive statistics, bivariate tests, multiple linear regression models, and complementary binary logistic regression models were utilised to identify variables independently associated with scores and clinical risk thresholds (EAT-26 >/= 20). Results: Multiple linear regression analysis determined that the scores indicating potential risk of altered eating behaviours (EAT-26) was primarily associated with female sex (beta = 0.134, p < 0.001), followed by never eating in company (beta = 0.149, p < 0.001), an active lifestyle (beta = 0.094, p = 0.001), excessive social media usage (beta = 0.088, p = 0.002), and smoking (beta = 0.091, p = 0.001). Likewise, susceptibility to sociocultural pressures (SATAQ-4) showed a major association with excessive digital connectivity (beta = 0.159, p < 0.001), female sex (beta = 0.094, p = 0.001), smoking (beta = 0.078, p = 0.004), both sometimes and never eating in company (beta = 0.078, p = 0.008 and beta = 0.082, p = 0.005 respectively), and younger age (beta = -0.202, p < 0.001). Furthermore, the binary logistic sensitivity analysis confirmed that a high clinical risk score (>/=20) was independently associated with female sex (Exp(B) = 2.660), smoking (Exp(B) = 2.381), never eating alone (Exp(B) = 2.253), excessive social media use (Exp(B) = 1.665), being active (Exp(B) = 1.500), a greater number of children (Exp(B) = 1.402), and younger age (Exp(B) = 0.969). Conclusions: Due to the non-probabilistic convenience nature of the sample, these findings cannot be directly generalized to the general population; however, they delineate the vulnerable demographic profile-young, active, female smokers who are frequent social media users and habitually eat alone-which may help generate hypotheses for future primary care prevention strategies. Furthermore, these results underscore the potential value of integrating specific screening considerations and digital literacy into person-centred healthcare, pending longitudinal validation. FAU - Hernandez Garre, Jose Manuel AU - Hernandez Garre JM AUID- ORCID: 0000-0002-2507-3121 AD - Department of Health Sciences, Social Anthropology Area, Catholic University of Murcia (UCAM), 30107 Murcia, Spain. FAU - Martinez, Irene Martinez AU - Martinez IM AD - Department of Nursing, University of Murcia, 30120 Murcia, Spain. FAU - Cardaba Garcia, Rosa Maria AU - Cardaba Garcia RM AD - Department of Nursing, University of Valladolid, 47003 Valladolid, Spain. FAU - Velasco Gonzalez, Veronica AU - Velasco Gonzalez V AUID- ORCID: 0000-0003-4739-9760 AD - Department of Nursing, University of Valladolid, 47003 Valladolid, Spain. FAU - Perez Soto, Maria Inmaculada AU - Perez Soto MI AD - Department of Nursing, University of Valladolid, 47003 Valladolid, Spain. FAU - Perez Perez, Lucia AU - Perez Perez L AUID- ORCID: 0000-0002-6031-6619 AD - Department of Nursing, University of Valladolid, 47003 Valladolid, Spain. FAU - Ferreira Diaz, Maria Jose AU - Ferreira Diaz MJ AUID- ORCID: 0009-0001-9046-9560 AD - University School of Nursing, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain. FAU - Morales Moreno, Isabel AU - Morales Moreno I AUID- ORCID: 0000-0003-1528-984X AD - Department of Health Sciences, Social Anthropology Area, Catholic University of Murcia (UCAM), 30107 Murcia, Spain. FAU - Peran, Maria Angeles Navarro AU - Peran MAN AD - Department of Nursing, University of Murcia, 30120 Murcia, Spain. FAU - de Maya Sanchez, Baldomero AU - de Maya Sanchez B AD - Department of Nursing, University of Valladolid, 47003 Valladolid, Spain. LA - eng PT - Journal Article DEP - 20260928 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13665222 OTO - NOTNLM OT - body image perception OT - digital health OT - eating disorders OT - health policy OT - person-centred care OT - primary care OT - risk profile COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:32 MHDA- 2026/10/16 05:33 PMCR- 2026/09/28 CRDT- 2026/10/16 01:00 PHST- 2026/08/18 00:00 [received] PHST- 2026/09/14 00:00 [revised] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/16 05:33 [medline] PHST- 2026/10/16 05:32 [pubmed] PHST- 2026/10/16 01:00 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - healthcare14193203 [pii] AID - healthcare-14-03203 [pii] AID - 10.3390/healthcare14193203 [doi] PST - epublish SO - Healthcare (Basel). 2026 Sep 28;14(19):3203. doi: 10.3390/healthcare14193203. PMID- 42881332 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261022 IS - 1447-0756 (Electronic) IS - 1341-8076 (Linking) VI - 52 IP - 10 DP - 2026 Oct TI - Clinical Predictors of Surgical Intervention and Ovarian Torsion in Adolescents With Ovarian Cystic Lesions. PG - e70504 LID - e70504 [pii] LID - 10.1111/jog.70504 [doi] AB - AIM: To identify clinical and ultrasonographic (US) factors associated with surgical intervention and ovarian torsion in adolescents with ovarian cystic lesions and to evaluate an exploratory clinical risk stratification framework. METHODS: This retrospective cohort study included 112 adolescents with ovarian cystic lesions > 30 mm managed at a tertiary pediatric surgery center between January 2023 and January 2026. Clinical presentation, US characteristics, management, and outcomes were evaluated. Height and weight measurements were retrospectively retrieved when available, and body mass index (BMI) was calculated and analyzed as a continuous variable. Multivariable logistic regression was used to identify factors independently associated with surgical intervention and ovarian torsion. Receiver operating characteristic (ROC) analysis was used to determine the optimal lesion diameter threshold for surgical intervention. A exploratory three-level clinical risk stratification framework was subsequently developed using the ROC-derived 60-mm lesion diameter threshold and the presence of abdominal/pelvic pain. RESULTS: Among 112 patients, 26 (23.2%) underwent surgical intervention, whereas 86 (76.8%) were managed conservatively. Surgical indications included ovarian torsion, complex adnexal masses, and persistent or enlarging cysts. Maximum lesion diameter was the strongest independent predictor of both surgical intervention and ovarian torsion. BMI was available for 95 patients (84.8%) and was not independently associated with surgical intervention or significantly different according to ovarian torsion status. The 60-mm threshold provided the best discrimination for surgical intervention. Surgical intervention occurred in 5/75 (6.7%), 2/8 (25.0%), and 19/29 (65.5%) patients in the low-, intermediate-, and high-risk groups, respectively (Fisher-Freeman-Halton exact test, p < 0.001). Ovarian torsion occurred in 2/75 (2.7%), 0/8 (0%), and 11/29 (37.9%) patients, respectively (Fisher-Freeman-Halton exact test, p < 0.001). CONCLUSIONS: Maximum lesion diameter was the strongest independent predictor of surgical intervention and ovarian torsion. BMI was not significantly associated with either outcome in the available anthropometric data. The new exploratory risk stratification framework showed distinct clinical patterns across risk categories but requires prospective external validation before clinical use. CI - (c) 2026 Japan Society of Obstetrics and Gynecology. FAU - Oztas, Tulin AU - Oztas T AUID- ORCID: 0000-0002-1010-3324 AD - Department of Pediatric Surgery, Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkiye. FAU - Asir, Aysegul AU - Asir A AD - Department of Pediatrics, Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkiye. LA - eng PT - Journal Article PL - Australia TA - J Obstet Gynaecol Res JT - The journal of obstetrics and gynaecology research JID - 9612761 SB - IM MH - Humans MH - Female MH - *Ovarian Torsion/surgery/diagnostic imaging/epidemiology MH - Adolescent MH - Retrospective Studies MH - *Ovarian Cysts/surgery/diagnostic imaging/complications/pathology MH - Ultrasonography OTO - NOTNLM OT - adolescent OT - ovarian cysts OT - ovarian torsion OT - risk factors OT - surgical procedures EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 CRDT- 2026/10/15 23:58 PHST- 2026/09/07 00:00 [revised] PHST- 2026/07/26 00:00 [received] PHST- 2026/09/12 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/15 23:58 [entrez] AID - e70504 [pii] AID - 10.1111/jog.70504 [doi] PST - ppublish SO - J Obstet Gynaecol Res. 2026 Oct;52(10):e70504. doi: 10.1111/jog.70504. PMID- 42880628 OWN - NLM STAT- Publisher LR - 20261015 IS - 1534-4436 (Electronic) IS - 1081-1206 (Linking) DP - 2026 Oct 15 TI - Pediatric Alpha-Gal Syndrome: From Missed Diagnosis to the Burden of Avoidance. LID - S1081-1206(26)01272-X [pii] LID - 10.1016/j.anai.2026.10.012 [doi] AB - BACKGROUND: Pediatric alpha-gal syndrome remains underrecognized because delayed reactions disconnect symptoms from mammalian exposure and gastrointestinal-only presentations may bypass allergy evaluation. Overly broad avoidance may subsequently impose nutritional and psychosocial burden during growth. OBJECTIVE: To synthesize pediatric evidence and provide a directed management framework emphasizing diagnostic delay, least-restrictive avoidance, nutritional burden, natural history, and reassessment. DATA SOURCES: A literature search was conducted using PubMed/MEDLINE for articles published through August 2026. STUDY SELECTIONS: Pediatric and age-stratified primary studies were prioritized. Adult and mixed-age studies informed areas with limited pediatric evidence, with consideration of their applicability to children. METHODS: Evidence was qualitatively synthesized by source; no risk-of-bias assessment was performed. RESULTS: Pediatric cohorts document prolonged diagnostic delay and frequent gastrointestinal-predominant presentations. Tick exposure is a key etiologic and diagnostic clue, but lack of a recalled bite does not exclude alpha-gal syndrome. Diagnosis requires a compatible delayed phenotype plus detectable alpha-gal-specific IgE; sensitization alone does not establish alpha-gal syndrome. Mammalian meat and internal organ meat are the core exclusions, whereas tolerated dairy should be preserved and additional restrictions individualized. Potential mammalian origin of a medication or vaccine warrants product-specific assessment rather than blanket avoidance. No prospective pediatric study has quantified dietary intake, nutrient status, growth, bone health, or quality of life. A 2026 meta-analysis of 1,162 predominantly adult or mixed-age patients found symptomatic improvement in 86.5% but complete resolution in 42.7%; no pediatric remission rate or validated challenge/reintroduction protocol exists. CONCLUSION: Care should combine cross-specialty evaluation, phenotype-directed testing, least-restrictive avoidance, nutritional surveillance, tick-bite prevention, emergency preparedness, and planned reassessment toward the broadest safely tolerated diet. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Miliordos, Konstantinos AU - Miliordos K AD - Pediatric Allergy Unit, Department of Pediatrics, General University Hospital of Patras, Patras, Greece. Electronic address: mhlcon95@gmail.com. FAU - Triga, Maria AU - Triga M AD - Pediatric Allergy Unit, Department of Pediatrics, General University Hospital of Patras, Patras, Greece. LA - eng PT - Journal Article PT - Review DEP - 20261015 PL - United States TA - Ann Allergy Asthma Immunol JT - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JID - 9503580 SB - IM OTO - NOTNLM OT - alpha-gal syndrome OT - children OT - delayed diagnosis OT - elimination diet OT - natural history OT - nutritional burden OT - oral food challenge OT - reintroduction EDAT- 2026/10/15 23:30 MHDA- 2026/10/15 23:30 CRDT- 2026/10/15 20:31 PHST- 2026/09/04 00:00 [received] PHST- 2026/10/08 00:00 [revised] PHST- 2026/10/09 00:00 [accepted] PHST- 2026/10/15 23:30 [medline] PHST- 2026/10/15 23:30 [pubmed] PHST- 2026/10/15 20:31 [entrez] AID - S1081-1206(26)01272-X [pii] AID - 10.1016/j.anai.2026.10.012 [doi] PST - aheadofprint SO - Ann Allergy Asthma Immunol. 2026 Oct 15:S1081-1206(26)01272-X. doi: 10.1016/j.anai.2026.10.012. PMID- 42879185 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261015 IS - 1365-277X (Electronic) IS - 0952-3871 (Linking) VI - 39 IP - 5 DP - 2026 Oct TI - Feasibility and Accuracy of Caregiver-Led Child Growth Measurements for Remote Healthcare. PG - e70364 LID - 10.1111/jhn.70364 [doi] AB - BACKGROUND AND AIMS: Remote healthcare is expanding, with accurate growth data essential for nutritional care. Guidance for routine caregiver-led measurements is limited and largely untested. This study evaluated the feasibility and accuracy of caregiver-led child growth measurements at home, compared to 'gold-standard' measurements in the hospital. METHODS: Caregivers of children attending outpatient appointments completed a survey on their access to weighing scales and tape measures at home. Those with suitable equipment were consented to participate in a home measurement study. Using provided instructions, caregivers measured their child twice within 48 h of a hospital appointment, where two healthcare professionals (HCPs) repeated measurements. Caregiver experiences were explored through short interviews. Agreement between methods was assessed using Bland-Altman analysis. RESULTS: Of 677 survey respondents (49% response), 61% owned both scales and tape measure, with ownership more likely in relatively affluent postcodes. One hundred and forty participants consented to the home measurement study but due to low recruitment in the 0-2-age group (n = 18), analysis was restricted to 122 2-15-year-olds with median age 8.5 [IQR 5,12]. Participants were predominantly white British (88%) from relatively affluent areas (78% IMD 5-10). LOA between caregivers and HCP were -3.46% to 3.79% (height) and -4.91% to 4.36% (weight), demonstrating reasonable caregiver accuracy. LOA between the two caregiver measurements were -0.97% to 0.99% (weight) and -1.04% to 0.80% (height), demonstrating consistency, and LOA between two HCPs were -0.48% to 0.53% (weight) and -0.61% to 0.55% (height), demonstrating good inter-observer agreement. The majority found the process straightforward, with greater confidence in weighing than in measuring, despite achieving lower accuracy. Most were willing to routinely provide measurements before remote appointments. CONCLUSIONS: Caregiver-led measurements appear feasible and reasonably accurate for children aged 2-15 years, although they may be more suitable to monitor trends, rather than in situations needing precision. Equipment access may be limited in less affluent areas, but generally, caregivers are willing to monitor weight and height at home. CI - (c) 2026 British Dietetic Association. FAU - Trace, Sarah L AU - Trace SL AUID- ORCID: 0000-0003-4408-1255 AD - Department of Nutrition and Dietetics, Bristol Hospitals NHS Foundation Trust, Bristol, UK. FAU - Leary, Sam D AU - Leary SD AUID- ORCID: 0000-0002-1706-0689 AD - Bristol Dental School, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK. FAU - Richards, Kara Y AU - Richards KY AUID- ORCID: 0009-0000-5917-6578 AD - Department of Nutrition and Dietetics, Bristol Hospitals NHS Foundation Trust, Bristol, UK. FAU - Shield, Julian P H AU - Shield JPH AUID- ORCID: 0000-0003-2601-7575 AD - NIHR Bristol Biomedical Research Centre, Diet and Physical Activity Theme, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK. LA - eng GR - British Dietetic Association/ PT - Journal Article PL - England TA - J Hum Nutr Diet JT - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JID - 8904840 SB - IM MH - Humans MH - *Caregivers MH - Child MH - Child, Preschool MH - Adolescent MH - Female MH - Feasibility Studies MH - Male MH - Infant MH - *Child Development MH - Reproducibility of Results MH - Adult MH - Infant, Newborn OTO - NOTNLM OT - anthropometry OT - caregiver OT - child OT - growth OT - measurements OT - parent OT - remote EDAT- 2026/10/15 23:30 MHDA- 2026/10/15 23:31 CRDT- 2026/10/15 18:43 PHST- 2026/09/23 00:00 [revised] PHST- 2026/06/08 00:00 [received] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/15 23:31 [medline] PHST- 2026/10/15 23:30 [pubmed] PHST- 2026/10/15 18:43 [entrez] AID - 10.1111/jhn.70364 [doi] PST - ppublish SO - J Hum Nutr Diet. 2026 Oct;39(5):e70364. doi: 10.1111/jhn.70364. PMID- 42876325 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261019 IS - 1654-9880 (Electronic) IS - 1654-9716 (Print) IS - 1654-9880 (Linking) VI - 19 IP - 1 DP - 2026 Dec TI - Predicting neurodevelopmental delay among two-year-old infants in Northern Uganda. PG - 2748101 LID - 10.1080/16549716.2026.2748101 [doi] LID - 2748101 AB - BACKGROUND: Data on neurodevelopmental disabilities in sub-Saharan Africa are scarce. Identifying children at the highest risk of neurodevelopmental delay could enable health workers to target these groups more effectively, improve resource allocation and programmatic focus. OBJECTIVE: To develop and assess a model for predicting neurodevelopmental delay among two-year-old infants in Northern Uganda using easily obtainable predictors. METHODS: We studied children born to women enrolled in a cluster randomized controlled trial (January 2018-March 2019) evaluating the effect of peer counseling on health facility births. At the trial's final visit (day 50), 1,804 children were enrolled. In November 2020, we followed up 1,421 children (78.8%) and assessed their neurodevelopment at 2 years using the Malawi Developmental Assessment Tool. We used least absolute shrinkage and selection operator penalized regression with 10-fold cross-validation to select the best subset of predictors and assessed model performance using the area under the curve (AUC). RESULTS: Of the 1,421 children, 70 (4.9%; 95% CI: 3.6-6.7%) had neurodevelopmental delays. Of the 19 candidate predictors, six were retained in the final model (lambda = 0.0076): moderate wasting, prolonged neonatal hospitalization (up to 28 days), maternal education, place of birth, preterm birth, and absence of skin-to-skin contact at birth. The model showed strong discriminative power (AUC 0.75) and reasonable calibration (calibration slope 1.37; calibration belt 0.536-0.727). CONCLUSION: We developed a promising tool for identifying infants at increased risk of neurodevelopmental delay in low-resource settings, which could help prioritize children for follow-up and specialized interventions. FAU - Mukunya, David AU - Mukunya D AUID- ORCID: 0000-0002-3892-9777 AD - Department of Community and Public Health, Busitema University, Mbale, Uganda. AD - Department of Research, Nikao Medical Center, Kampala, Uganda. FAU - Ndeezi, Grace AU - Ndeezi G AD - Department of Paediatrics and Child Health, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda. FAU - Namazzi, Gertrude AU - Namazzi G AD - Department of Paediatrics and Child Health, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda. AD - Department of Health Policy, Planning and Management, School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda. FAU - Tylleskar, Thorkild AU - Tylleskar T AUID- ORCID: 0000-0003-4801-4324 AD - Center for Internation Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. FAU - Nambozo, Brendah AU - Nambozo B AUID- ORCID: 0009-0002-8600-8654 AD - Department of Community and Public Health, Busitema University, Mbale, Uganda. AD - Center for Internation Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. FAU - Musaba, Milton W AU - Musaba MW AD - Department of Obstetrics and Gynaecology, Busitema University Faculty of Health Sciences, Mbale, Uganda. FAU - Odongkara, Beatrice AU - Odongkara B AD - Department of Paediatrics and Child Health, Gulu University, Gulu, Uganda. FAU - Achora, Vincentina AU - Achora V AD - Department of Obstetrics and Gynaecology, Gulu University, Gulu, Uganda. FAU - Tongun, Justin Bruno AU - Tongun JB AD - Department of Paediatrics and Child Health, University of Juba, Juba, South Sudan. FAU - Tumuhamye, Josephine AU - Tumuhamye J AUID- ORCID: 0000-0001-5451-6406 AD - Department of Research, Makerere University Hospital, Kampala, Uganda. FAU - Napyo, Agnes AU - Napyo A AUID- ORCID: 0000-0003-4333-3588 AD - Department of Nursing, School of Medicine, Kabale University, Kabale, Uganda. FAU - Ssentumbwe, Vicent AU - Ssentumbwe V AD - Division of Computational and Data Science, Washington University in St. Louis, St. Louis, MO, USA. FAU - Nankabirwa, Victoria AU - Nankabirwa V AD - Centre for Intervention Science and Maternal Child Health (CISMAC), Centre for International Health, University of Bergen, Bergen, Norway. AD - Department of Epidemiology and Biostatistics, School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda. FAU - Tumwine, James K AU - Tumwine JK AD - Department of Paediatrics and Child Health, Kabale University, Kabale, Uganda. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20261015 PL - United States TA - Glob Health Action JT - Global health action JID - 101496665 SB - IM MH - Humans MH - Uganda/epidemiology MH - Female MH - Male MH - Child, Preschool MH - *Developmental Disabilities/epidemiology/diagnosis MH - *Neurodevelopmental Disorders/epidemiology MH - Risk Factors MH - Infant PMC - PMC13674651 OAB - Main findings: we developed and evaluated a risk prediction model that identified six readily available factors associated with neurodevelopmental delay among infants in Northern Uganda and demonstrated a good ability to distinguish children at increased risk.Added knowledge: this study provides evidence that routinely collected maternal, birth, and early infant characteristics can be used to support early identification of children who may benefit from targeted neurodevelopmental follow-up.Global health impact for policy and action: the findings provide a practical approach for low-resource settings to improve early detection, prioritize limited resources, and guide interventions to reduce the burden of neurodevelopmental disabilities. OABL- eng OTO - NOTNLM OT - Early child development; thriving OT - human capacity development OT - human capital OT - low-income countries OT - neurodevelopmental delay OT - risk stratification COIS- No potential conflict of interest was reported by the author(s). EDAT- 2026/10/15 07:18 MHDA- 2026/10/15 07:19 PMCR- 2026/10/15 CRDT- 2026/10/15 03:53 PHST- 2026/10/15 07:19 [medline] PHST- 2026/10/15 07:18 [pubmed] PHST- 2026/10/15 03:53 [entrez] PHST- 2026/10/15 00:00 [pmc-release] AID - 2748101 [pii] AID - 10.1080/16549716.2026.2748101 [doi] PST - ppublish SO - Glob Health Action. 2026 Dec;19(1):2748101. doi: 10.1080/16549716.2026.2748101. Epub 2026 Oct 15. PMID- 42876010 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261023 IS - 1643-3750 (Electronic) IS - 1234-1010 (Print) IS - 1234-1010 (Linking) VI - 32 DP - 2026 Oct 15 TI - Validation of the Children and Adolescents Physical Activity and Sedentary Questionnaire (CAPAS-Q) in Polish Children and Adolescents. PG - e953567 LID - 10.12659/MSM.953567 [doi] LID - e953567 AB - BACKGROUND Global public health faces challenges related to low physical activity (PA) and excessive sedentary behavior (SB) among youth. This study aimed to validate the Polish version of the Children and Adolescents Physical Activity and Sedentary Questionnaire (CAPAS-Q). MATERIAL AND METHODS The study involved 206 participants (114 girls, 92 boys) aged 8 to 17 years. Participants completed the CAPAS-Q twice (7-day interval) to assess test-retest reliability. Objective PA and SB data were collected concurrently using ActiGraph wGT3X-BT accelerometers. Psychometric evaluation included internal consistency (Cronbach's alpha), test-retest reliability (intraclass correlation coefficient [ICC]), and criterion validity (Spearman's rank correlation [rs]). RESULTS Internal consistency was acceptable (Cronbach's alpha 0.674 for PA and 0.754 for SB). Test-retest reliability was good to excellent, with subscale ICCs of 0.7429 to 0.9375. For criterion validity, the SB dimension showed moderate correlations with accelerometer-derived total PA (rs=-0.41) and sedentary time (rs=0.41). PA subscale correlations were generally smaller, with the highest association found between sports/leisure PA and moderate to vigorous PA (rs=0.27). Psychometric properties varied by group, with lower PA validity in younger children and adolescent girls. CONCLUSIONS The Polish CAPAS-Q demonstrates good to excellent test-retest reliability, although its internal consistency varies across subgroups, being lower in younger children. While the tool shows moderate criterion validity for SBs, its validity for quantifying PA volume is weak. Nevertheless, the CAPAS-Q provides valuable contextual and qualitative data. It is recommended as a cost-effective instrument for contextual screening in epidemiological studies, but caution is advised when interpreting PA levels in younger children and adolescent girls. FAU - Baran, Rafal AU - Baran R AUID- ORCID: 0000-0001-9638-9505 AD - Faculty of Health Sciences and Psychology, Institute of Physiotherapy, University of Rzeszow, Rzeszow, Poland. FAU - Baran, Joanna AU - Baran J AUID- ORCID: 0000-0001-8354-1651 AD - Faculty of Health Sciences and Psychology, Institute of Physiotherapy, University of Rzeszow, Rzeszow, Poland. FAU - Leszczak, Justyna AU - Leszczak J AUID- ORCID: 0000-0001-8769-0048 AD - Faculty of Health Sciences and Psychology, Institute of Physiotherapy, University of Rzeszow, Rzeszow, Poland. FAU - Fillon, Alicia AU - Fillon A AUID- ORCID: 0000-0002-0614-8909 AD - Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), EA 3533, Clermont Auvergne University, CRNH Auvergne, Clermont-Ferrand, France. AD - National Observatory for Physical Activity and Sedentary Behaviors (ONAPS), UFR Medicine, University Clermont Auvergne, Clermont-Ferrand, France. FAU - Thivel, David AU - Thivel D AUID- ORCID: 0000-0003-4687-3555 AD - Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), EA 3533, Clermont Auvergne University, CRNH Auvergne, Clermont-Ferrand, France. AD - National Observatory for Physical Activity and Sedentary Behaviors (ONAPS), UFR Medicine, University Clermont Auvergne, Clermont-Ferrand, France. FAU - Wyszynska, Justyna AU - Wyszynska J AUID- ORCID: 0000-0002-5786-6214 AD - Faculty of Health Sciences and Psychology, Institute of Physiotherapy, University of Rzeszow, Rzeszow, Poland. LA - eng PT - Journal Article PT - Validation Study DEP - 20261015 PL - United States TA - Med Sci Monit JT - Medical science monitor : international medical journal of experimental and clinical research JID - 9609063 SB - IM MH - Humans MH - Child MH - Female MH - Adolescent MH - *Sedentary Behavior MH - Poland MH - Surveys and Questionnaires MH - *Exercise/physiology/psychology MH - Male MH - Reproducibility of Results MH - Psychometrics/methods MH - Accelerometry/methods PMC - PMC13685572 COIS- Conflict of interest: None declared EDAT- 2026/10/15 07:18 MHDA- 2026/10/15 07:19 PMCR- 2026/10/15 CRDT- 2026/10/15 01:22 PHST- 2026/10/15 07:19 [medline] PHST- 2026/10/15 07:18 [pubmed] PHST- 2026/10/15 01:22 [entrez] PHST- 2026/10/15 00:00 [pmc-release] AID - 953567 [pii] AID - 10.12659/MSM.953567 [doi] PST - epublish SO - Med Sci Monit. 2026 Oct 15;32:e953567. doi: 10.12659/MSM.953567. PMID- 42874221 OWN - NLM STAT- Publisher LR - 20261014 IS - 1872-7727 (Electronic) IS - 0720-048X (Linking) VI - 206 DP - 2026 Oct 9 TI - Quantitative ultrasound-derived estimated fat fraction for detection and grading of metabolic dysfunction-associated steatotic liver disease in a pediatric population. PG - 113294 LID - S0720-048X(26)00642-X [pii] LID - 10.1016/j.ejrad.2026.113294 [doi] AB - BACKGROUND: Pediatric metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is approximately 10%, but ultrasound fat quantification lacks validation. This study evaluated the diagnostic performance of quantitative ultrasound-derived estimated fat fraction (USFF) against magnetic resonance imaging proton density fat fraction (MRI-PDFF) in children with suspected MASLD. METHODS: This prospective single-center study enrolled 65 children aged 6-18 years with suspected MASLD. USFF, tissue attenuation imaging (TAI), tissue scatter distribution imaging (TSI), hepato-renal index (EzHRI), and shear wave elastography (SWE) were measured on a Samsung R10 Prestige platform; 3.0 T MRI-PDFF served as reference. Steatosis was graded using pediatric PDFF thresholds. Diagnostic performance was assessed by ROC analysis with DeLong comparisons and internally validated by bootstrap resampling; agreement by Bland-Altman analysis; inter-operator reproducibility assessed in a randomly selected 30-child subset. RESULTS: Among 65 children (48 boys; median age 11.2 years), 20 were classified as S0, 29 as S1, and 16 as S2-3. USFF AUCs were 0.941 (>/=S1) and 0.960 (>/=S2), higher than EzHRI and SWE, and similar to TAI (0.903, 0.957) and TSI (0.900, 0.880). USFF strongly correlated with MRI-PDFF (rho = 0.906) but systematically underestimated PDFF (mean bias - 3.13%; non-parametric limits of agreement - 14.51% to + 4.24%). In an exploratory analysis, younger children (<12 years) showed larger bias (-4.00% vs - 1.82%, p = 0.029) with similar AUC point estimates. CONCLUSIONS: USFF shows high diagnostic performance (AUC > 0.94) for pediatric MASLD, but its 3.13% underestimation and wide non-parametric limits of agreement warrant caution. USFF may serve as a practical tool for categorical steatosis grading in children with suspected MASLD, and the proposed thresholds require external validation before clinical use. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Wang, Yujue AU - Wang Y AD - Department of Ultrasound, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. FAU - Du, Lanxin AU - Du L AD - Department of Ultrasound, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. FAU - Yang, Caiwei AU - Yang C AD - Department of Radiology, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Wang, Qian AU - Wang Q AD - Department of Ultrasound, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. FAU - Pang, Houqing AU - Pang H AD - Department of Ultrasound, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. Electronic address: panghouqing75@163.com. FAU - Li, Ping AU - Li P AD - Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, NHC Key Laboratory of Chronobiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. Electronic address: pingli_0415@scu.edu.cn. LA - eng PT - Journal Article DEP - 20261009 PL - Ireland TA - Eur J Radiol JT - European journal of radiology JID - 8106411 SB - IM OTO - NOTNLM OT - Adiposity OT - MASLD OT - Magnetic resonance imaging OT - Pediatric OT - Quantitative ultrasound OT - Ultrasonography COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/14 23:32 MHDA- 2026/10/14 23:32 CRDT- 2026/10/14 18:05 PHST- 2026/08/05 00:00 [received] PHST- 2026/09/17 00:00 [revised] PHST- 2026/10/08 00:00 [accepted] PHST- 2026/10/14 23:32 [medline] PHST- 2026/10/14 23:32 [pubmed] PHST- 2026/10/14 18:05 [entrez] AID - S0720-048X(26)00642-X [pii] AID - 10.1016/j.ejrad.2026.113294 [doi] PST - aheadofprint SO - Eur J Radiol. 2026 Oct 9;206:113294. doi: 10.1016/j.ejrad.2026.113294. PMID- 42871714 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261014 LR - 20261015 IS - 2980-2156 (Electronic) IS - 2980-2156 (Linking) VI - 48 IP - 5 DP - 2026 Sep TI - Limited Public Health Utility of LCT Genotyping for Lactose Intolerance Screening in Adolescents: A Cross-Sectional Study from Turkiye. PG - 505-511 LID - 10.14744/cpr.2026.33422 [doi] AB - OBJECTIVE: Lactose intolerance (LI) is a common cause of gastrointestinal complaints in adolescents and young adults, often leading to unnecessary dietary restrictions and reduced calcium intake. Although lactase non-persistence (LNP) is genetically determined, its clinical expression varies considerably. Genetic variants associated with lactase persistence/non-persistence (LCT/MCM6 locus), particularly rs4988235 and rs3754686, are frequently used in genetic testing; however, their clinical utility remains uncertain, especially in populations with a high prevalence of LNP, such as Turkiye. MATERIALS AND METHODS: In this cross-sectional study, 209 individuals aged 12-25 years were evaluated. Lactose-related symptoms were assessed using a validated questionnaire (a score >/=7 defined symptomatic individuals). Consumption of raw milk and fermented dairy products was recorded using a standardized frequency scale. Genotyping of rs4988235 and rs3754686 was performed using TaqMan real-time PCR. Associations between genotype, symptom status, age at symptom onset, and dietary patterns were statistically analyzed. RESULTS: Among the participants, 116 (55.5%) were symptomatic and 93 (44.5%) were asymptomatic. Symptomatic individuals were significantly older (p<0.001). The genotype distributions of rs4988235 and rs3754686 did not differ between symptomatic and asymptomatic individuals and were not associated with age at symptom onset. Dairy consumption patterns were not associated with symptom severity, although fermented dairy consumption was slightly higher among symptomatic individuals (p=0.046). CONCLUSION: Common LCT/MCM6 variants did not predict clinical LI in this adolescent and young adult population. Therefore, routine genetic testing appears unlikely to provide limited additional value in supporting the diagnosis of lactose intolerance, particularly in populations with a high prevalence of LNP. Symptom-based assessment and functional testing should remain central to diagnosis and management, and, supporting appropriate nutritional guidance and avoiding unnecessary dietary restriction. CI - Copyright (c) Author(s). FAU - Mutlu, Hatice AU - Mutlu H AD - Department of Pediatric Genetics, Ankara University Faculty of Medicine, Ankara, Turkiye. AD - Rare Disease Application and Research Center (NADIR), Ankara University, Ankara, Turkiye. FAU - Eker, Ece AU - Eker E AD - Department of Pediatric Genetics, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Cetinkaya, Fulya AU - Cetinkaya F AD - Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Egin, Yonca AU - Egin Y AD - Department of Pediatric Genetics, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Aydin, Sengul AU - Aydin S AD - Department of Pediatric Genetics, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Vatansever, Goksel AU - Vatansever G AD - Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Guven, Ayse Gul AU - Guven AG AD - Department of Adolescent Health, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Aycan, Zehra AU - Aycan Z AD - Department of Adolescent Health, Ankara University Faculty of Medicine, Ankara, Turkiye. AD - Department of Pediatric Endocrinology, Ankara University Faculty of Medicine, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260929 PL - Turkey TA - J Clin Pract Res JT - Journal of clinical practice and research JID - 9919014495706676 PMC - PMC13659205 OTO - NOTNLM OT - Adolescents OT - LCT OT - MCM6 OT - dairy consumption OT - lactose intolerance COIS- The authors have no conflicts of interest to declare. EDAT- 2026/10/14 18:14 MHDA- 2026/10/14 18:15 PMCR- 2026/09/29 CRDT- 2026/10/14 11:20 PHST- 2026/02/25 00:00 [received] PHST- 2026/08/19 00:00 [revised] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/10/14 18:15 [medline] PHST- 2026/10/14 18:14 [pubmed] PHST- 2026/10/14 11:20 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - JCPR-48-505 [pii] AID - 10.14744/cpr.2026.33422 [doi] PST - epublish SO - J Clin Pract Res. 2026 Sep 29;48(5):505-511. doi: 10.14744/cpr.2026.33422. eCollection 2026 Sep. PMID- 42871394 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261015 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Cross-cultural adaptation and initial psychometric evaluation of the fruit and vegetable self-efficacy scales among secondary school adolescents in Selangor, Malaysia. PG - 1920784 LID - 10.3389/fpubh.2026.1920784 [doi] LID - 1920784 AB - Fruit and vegetable self-efficacy may influence adolescent dietary behavior, yet culturally adapted measures for Malaysian adolescents remain limited. This study aimed to cross-culturally adapt the 17-item Fruit Self-Efficacy (FSE) and Vegetable Self-Efficacy (VSE) scales into Malay and obtain initial evidence on their measurement properties. The study comprised two sequential phases. Phase 1 involved forward and backward translation, cognitive debriefing with five adolescents, linguistic equivalence assessment by six experts, content validity assessment by nine experts, qualitative and quantitative face validity assessment involving 15 unique adolescents, and pretesting with 37 adolescents. Phase 2 comprised an initial psychometric evaluation among 128 adolescents from four classes in one purposively selected public secondary school in Selangor. The adaptation process included age-appropriate refinements to the linguistic and contextual aspects of fruit and vegetable preparation, snacks, social occasions, serving terminology, and meal contexts. In particular, "pieces of fruit" was adapted to "servings of fruit" and supported by a pictorial serving guide, while "hot meal" was contextualized as "main meal." All source items met the prespecified content-validity criteria. Scale-level content-validity indices were 0.99 for FSE and 0.95 for VSE, while scale-level face-validity indices ranged from 0.95 to 0.97. One FSE item with an initial clarity index below the criterion was revised using concrete preparation examples and reassessed. In the separate psychometric sample, the prespecified one-factor FSE model showed acceptable fit (CFI = 0.974, TLI = 0.970, RMSEA = 0.069, SRMR = 0.061), although pronounced item-level ceiling effects were observed. The prespecified VSE model showed substantial misfit (RMSEA = 0.136, SRMR = 0.099), and its structural validity was not established. A same-sample post hoc specification with six correlated residuals remained hypothesis-generating because its RMSEA was 0.094. The multistage process produced linguistically and culturally adapted FSE and VSE scales that met the prespecified content and face-validity criteria among the expert and adolescent samples assessed. However, evidence supporting the one-factor structure was stronger for FSE than VSE. Further cognitive investigation and adequately powered, independent multisite evaluation across diverse ethnic and age groups are required before broader use. CI - Copyright (c) 2026 Zaini, Jabir, Mat Ludin, Abd Talib and Ishak. FAU - Zaini, Zanariah AU - Zaini Z AD - Centre for Toxicology and Health Risk, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. AD - Institute for Health Behavioural Research, National Institutes of Health, Ministry of Health, Shah Alam, Malaysia. FAU - Jabir, Nursyazwani AU - Jabir N AD - Institute for Health Behavioural Research, National Institutes of Health, Ministry of Health, Shah Alam, Malaysia. FAU - Mat Ludin, Arimi Fitri AU - Mat Ludin AF AD - Centre for Healthy Ageing and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. FAU - Abd Talib, Ruzita AU - Abd Talib R AD - Centre for Community Health Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. FAU - Ishak, Ismarulyusda AU - Ishak I AD - Centre for Toxicology and Health Risk, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. LA - eng PT - Journal Article DEP - 20260929 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Malaysia MH - Psychometrics MH - *Fruit MH - *Self Efficacy MH - *Vegetables MH - Adolescent MH - Female MH - *Cross-Cultural Comparison MH - Male MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - Schools PMC - PMC13658580 OTO - NOTNLM OT - adolescents OT - cross-cultural adaptation OT - fruit and vegetable intake OT - questionnaire adaptation OT - self-efficacy COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/14 11:34 MHDA- 2026/10/14 11:35 PMCR- 2026/09/29 CRDT- 2026/10/14 09:51 PHST- 2026/06/26 00:00 [received] PHST- 2026/09/09 00:00 [revised] PHST- 2026/09/14 00:00 [accepted] PHST- 2026/10/14 11:35 [medline] PHST- 2026/10/14 11:34 [pubmed] PHST- 2026/10/14 09:51 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1920784 [doi] PST - epublish SO - Front Public Health. 2026 Sep 29;14:1920784. doi: 10.3389/fpubh.2026.1920784. eCollection 2026. PMID- 42871234 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261014 LR - 20261015 IS - 1179-1411 (Print) IS - 1179-1411 (Electronic) IS - 1179-1411 (Linking) VI - 18 DP - 2026 TI - Advanced Maternal Age and Risk of Large-for-Gestational-Age Infants: Mediating Roles of Prenatal Body Mass Index and Specific Lipid Profiles. PG - 642291 LID - 10.2147/IJWH.S642291 [doi] LID - 642291 AB - BACKGROUND: Advanced maternal age (AMA) is associated with adverse pregnancy outcomes, but the mechanisms linking AMA to fetal overgrowth remain poorly quantified. This retrospective cohort study aimed to estimate the potential statistical mediating roles of prenatal BMI and blood lipids in the association between AMA and large-for-gestational-age (LGA) infants. METHODS: In this retrospective cohort study, 11,504 singleton pregnancies (28-41 weeks) in Changzhou, China, were analyzed. Women were classified as AMA (>/=35 years, n=1,330) or non‑AMA (n=10,174). Multivariable regression and mediation analyses assessed associations between AMA, lipid profiles, BMI, and LGA risk. RESULTS: AMA pregnancies showed significantly higher LGA rates than non-AMA pregnancies (24.44% vs 14.37%, P<0.001). After adjustment, AMA independently increased LGA risk (adjusted OR: 1.37, 95% CI: 1.18-1.60, P<0.001). AMA was associated with higher prenatal BMI (beta=0.37 kg/m(2)), elevated triglycerides (beta=0.27 mmol/L), and lower low density lipoprotein-cholesterol (LDL-C) (beta=-0.07 mmol/L) (all P<0.001). These metabolic factors independently predicted LGA risk: BMI (adjusted OR: 1.20 per 1 kg/m(2) increase), triglycerides (adjusted OR: 1.13 per 1 mmol/L increase), and LDL-C (adjusted OR: 1.32 per 1 mmol/L decrease) (all P<0.001). Exploratory mediation analysis estimated that prenatal BMI statistically accounted for 19.8% of the total AMA‑LGA effect, while triglycerides and LDL‑C accounted for 5.1% and 2.8%, respectively. CONCLUSION: AMA is independently associated with increased LGA risk, and this association is statistically partially mediated by higher BMI, elevated triglycerides, and lower LDL‑C. Given the retrospective observational design and the single‑timepoint measurement of lipids at delivery, these findings should be interpreted as statistical decompositions of associations rather than as causal. Nevertheless, they suggest that BMI and lipid profiles may be useful for risk stratification in older pregnant women, though prospective validation is warranted. CI - (c) 2026 Zhang et al. FAU - Zhang, Bin AU - Zhang B AD - Department of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, People's Republic of China. FAU - Yan, Qi AU - Yan Q AD - Department of Obstetrics and Gynecology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China. FAU - Zhan, Zhaolong AU - Zhan Z AUID- ORCID: 0009-0005-6012-0658 AD - Department of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, People's Republic of China. FAU - Chen, Xusheng AU - Chen X AUID- ORCID: 0009-0003-5032-8709 AD - Department of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, People's Republic of China. FAU - Yuan, Xiaosong AU - Yuan X AD - Department of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, People's Republic of China. LA - eng PT - Journal Article DEP - 20261008 PL - New Zealand TA - Int J Womens Health JT - International journal of women's health JID - 101531698 PMC - PMC13658422 OTO - NOTNLM OT - advanced maternal age OT - body mass index OT - large for gestational age OT - lipid profiles OT - mediation analysis COIS- The authors declare that they have no conflicts of interest. EDAT- 2026/10/14 11:34 MHDA- 2026/10/14 11:35 PMCR- 2026/10/08 CRDT- 2026/10/14 08:43 PHST- 2026/07/29 00:00 [received] PHST- 2026/09/30 00:00 [accepted] PHST- 2026/10/14 11:35 [medline] PHST- 2026/10/14 11:34 [pubmed] PHST- 2026/10/14 08:43 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - 642291 [pii] AID - 10.2147/IJWH.S642291 [doi] PST - epublish SO - Int J Womens Health. 2026 Oct 8;18:642291. doi: 10.2147/IJWH.S642291. eCollection 2026. PMID- 42871191 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261015 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Initial screening positivity for suspected scoliosis and machine learning-assisted risk prioritization: a school-based cross-sectional study in Wuhai, Inner Mongolia, China. PG - 1923480 LID - 10.3389/fpubh.2026.1923480 [doi] LID - 1923480 AB - BACKGROUND: Questionnaire-based prescreening is inexpensive, but its ability to identify students with abnormal scoliosis screening findings is uncertain. We assessed whether questionnaire variables improved prediction beyond a demographic and anthropometric baseline and whether simple on-site physical signs could further improve risk prioritization. The outcome was initial screening positivity, defined by a positive Adams forward-bend test together with an angle of trunk rotation (ATR) of >/=5 degrees . METHODS: This school-based cross-sectional study included 3,559 students aged 10-18 years from four schools in Wuhai, Inner Mongolia, China. Participants underwent anthropometry, postural examination, the Adams test, electronic ATR measurement after a visually positive Adams test, and a structured questionnaire. Questionnaire models were assessed first. As questionnaire variables did not improve the demographic and anthropometric baseline, the final models used age, sex, grade, BMI, shoulder asymmetry, and foot arch morphology. Logistic regression, random forest, and XGBoost were evaluated with five-fold stratified cross-validation repeated three times. RESULTS: Of 3,559 students, 392 (11.01%) met the initial screening-positive definition. Among models without physical signs, the demographic and anthropometric baseline model performed best (ROC-AUC, 0.633; PR-AUC, 0.163), while adding all or selected questionnaire variables did not improve performance. Among physical-sign models, random forest had the highest ROC-AUC (0.787) and PR-AUC (0.400), and the lowest Brier score (0.082), although its ROC-AUC gain over logistic regression was modest (0.014; 95% CI, -0.001 to 0.029). Prioritizing the top 30% by risk identified 258 of 392 positive results (65.8%); approximately 60.4% of students required prioritization to achieve 90% sensitivity. CONCLUSION: Questionnaire information did not support individual prescreening. Simple physical signs improved internal risk ranking for initial screening positivity, but the model cannot replace the combined screening procedure or diagnosis. External validation against clinical and radiographic reference standards is needed. CI - Copyright (c) 2026 Wang, Liu, Wang, Duan, Zhang, Li, Yan and Hai. FAU - Wang, Hongyan AU - Wang H AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. FAU - Liu, Xiafei AU - Liu X AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. FAU - Wang, Biao AU - Wang B AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. FAU - Duan, Lijuan AU - Duan L AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. FAU - Zhang, Xia AU - Zhang X AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. FAU - Li, Ying AU - Li Y AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. FAU - Yan, Cuitao AU - Yan C AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. FAU - Hai, Donghu AU - Hai D AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. LA - eng PT - Journal Article DEP - 20260929 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Cross-Sectional Studies MH - China/epidemiology MH - *Scoliosis/diagnosis/epidemiology MH - Child MH - Female MH - *Machine Learning MH - Male MH - Adolescent MH - Surveys and Questionnaires MH - *Mass Screening/methods MH - Risk Assessment MH - Schools PMC - PMC13658430 OTO - NOTNLM OT - adolescents OT - children OT - machine learning OT - risk prioritization OT - school health OT - scoliosis screening COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/14 11:34 MHDA- 2026/10/14 11:35 PMCR- 2026/09/29 CRDT- 2026/10/14 08:27 PHST- 2026/06/30 00:00 [received] PHST- 2026/08/28 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/14 11:35 [medline] PHST- 2026/10/14 11:34 [pubmed] PHST- 2026/10/14 08:27 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1923480 [doi] PST - epublish SO - Front Public Health. 2026 Sep 29;14:1923480. doi: 10.3389/fpubh.2026.1923480. eCollection 2026. PMID- 42870901 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261014 LR - 20261015 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Negative school gossip, self-esteem, and exercise intention among Chinese adolescents: a mediation model. PG - 1923752 LID - 10.3389/fpsyg.2026.1923752 [doi] LID - 1923752 AB - PURPOSE: This study examined the associations among negative school gossip, self-esteem, and general exercise intention among Chinese adolescents, with particular attention to the mediating role of self-esteem and the relevance of these associations to physical education (PE) and school-based movement contexts. METHODS: A cross-sectional online questionnaire survey was conducted among 1,713 junior middle school students in China. Negative school gossip, self-esteem, and exercise intention were assessed using established self-report scales. Data were analyzed using latent-variable structural equation modeling in Mplus 8.3. Common method bias, reliability, convergent validity, discriminant validity, and model fit were examined before testing the mediation model. Bias-corrected bootstrap analysis with 2,000 bootstrap samples was used to test the indirect association. A sensitivity analysis was conducted by controlling for gender, grade, region, parental education, only-child status, and family economic status. RESULTS: The three-factor measurement model showed better fit than alternative measurement models, and the measures demonstrated acceptable reliability and validity. In the main structural model, negative school gossip was negatively associated with self-esteem (beta = -0.157, p < 0.001) and exercise intention (beta = -0.063, p = 0.031), while self-esteem was positively associated with exercise intention (beta = 0.240, p < 0.001). The standardized indirect association from negative school gossip to exercise intention through self-esteem was significant [beta = -0.038, 95% bootstrap CI (-0.055, -0.024)], accounting for 37.62% of the total association. The pattern remained stable after controlling for demographic covariates. CONCLUSION: Negative school gossip was associated with weaker general exercise intention among Chinese adolescents, and self-esteem partly accounted for this association. Although exercise intention was not measured specifically for PE lessons, the findings are relevant to PE because school movement contexts are highly visible and peer-evaluative settings in which reputation-based exclusion and stigma may reduce psychological safety. The results therefore suggest that supportive peer climates and protection from gossip-related exclusion may be important for inclusive PE and equitable participation in school-based physical activity. CI - Copyright (c) 2026 Ma and Chen. FAU - Ma, Jiaxin AU - Ma J AD - School of Humanities and Arts, Deyang College of Urban Rail Transit, Deyang, Sichuan, China. FAU - Chen, Xingtong AU - Chen X AD - School of Sports Training, Chengdu Sport University, Chengdu, Sichuan, China. LA - eng PT - Journal Article DEP - 20260929 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13657928 OTO - NOTNLM OT - Chinese adolescents OT - exercise intention OT - mediation OT - negative school gossip OT - self-esteem OT - structural equation modeling COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/14 11:34 MHDA- 2026/10/14 11:35 PMCR- 2026/09/29 CRDT- 2026/10/14 05:35 PHST- 2026/06/30 00:00 [received] PHST- 2026/09/14 00:00 [revised] PHST- 2026/09/16 00:00 [accepted] PHST- 2026/10/14 11:35 [medline] PHST- 2026/10/14 11:34 [pubmed] PHST- 2026/10/14 05:35 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1923752 [doi] PST - epublish SO - Front Psychol. 2026 Sep 29;17:1923752. doi: 10.3389/fpsyg.2026.1923752. eCollection 2026. PMID- 42870691 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261016 IS - 1467-7687 (Electronic) IS - 1363-755X (Print) IS - 1363-755X (Linking) VI - 29 IP - 6 DP - 2026 Nov TI - Exploring a Range of Potential Factors Promoting and Constraining EF in South African Preschoolers. PG - e70289 LID - 10.1111/desc.70289 [doi] LID - e70289 AB - BACKGROUND: Socioeconomic disadvantage is widely associated with poorer cognitive and educational outcomes. However, emerging evidence suggests that children in low-income contexts may demonstrate resilience in executive function (EF) development. This study examined the predictors of EF in South African preschoolers from disadvantaged communities to identify modifiable, context-specific influences. METHODS: 125 Children (aged 3-5 years) and their caregivers were recruited from 15 early childhood centers in Cape Town. Children completed three tablet-based EF tasks from the Early Years Toolbox measuring working memory, inhibition, shifting, while caregivers reported on demographic variables, household assets, child sleep, child screen time, child exposure to violence, and parenting practices. Multiple linear regressions examined predictors of child EF, with exploratory analyses on a subset (n = 22) for hair cortisol analysis. RESULTS: Older child age (beta = 0.37, p < 0.001), caregiver secondary education (beta = 0.22, p = 0.003), and fewer sleep difficulties (beta = -0.45, p = 0.042) significantly predicted higher child EF scores, together explaining 25% of variance. Household assets, screen time, violence exposure, and parenting scores were non-significant. In the subsample, hair cortisol concentration correlated positively with EF (rho = 0.55, p = 0.009), suggesting potential adaptive calibration under adversity. CONCLUSIONS: Findings highlight that modifiable proximal factors (e.g., caregiver education and child sleep) shape EF development more strongly than socioeconomic indicators. Results challenge the presumed universality of SES-EF gradients and underscore the importance of culturally grounded, contextually validated measures for understanding resilience and early cognitive development in Majority World settings. CI - (c) 2026 The Author(s). Developmental Science published by John Wiley & Sons Ltd. FAU - Beukes, Johanna AU - Beukes J AUID- ORCID: 0000-0003-2644-7081 AD - SAMRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. FAU - Cook, Caylee AU - Cook C AD - SAMRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. FAU - Howard, Steven J AU - Howard SJ AUID- ORCID: 0000-0002-1258-3210 AD - Early Start and School of Education, University of Wollongong, Wollongong, NSW, Australia. FAU - Scerif, Gaia AU - Scerif G AUID- ORCID: 0000-0002-6371-8875 AD - Department of Experimental Psychology, University of Oxford, Oxford, UK. FAU - Sharpley, Christopher F AU - Sharpley CF AUID- ORCID: 0000-0001-7922-4848 AD - Department of Neuroscience, University of New England, Armidale, NSW, Australia. FAU - Hart, Robert AU - Hart R AD - Department of Biomedical Sciences, University of New England, Armidale, NSW, Australia. FAU - Draper, Catherine AU - Draper C AUID- ORCID: 0000-0002-2885-437X AD - SAMRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. LA - eng GR - University of Wollongong/ GR - DSI-NRF Centre of Excellence in Human Development, University of the Witwatersrand, Johannesburg/ GR - University of Wollogong/ PT - Journal Article PL - England TA - Dev Sci JT - Developmental science JID - 9814574 RN - WI4X0X7BPJ (Hydrocortisone) SB - IM MH - Humans MH - Child, Preschool MH - Female MH - South Africa MH - Male MH - *Executive Function/physiology MH - Hydrocortisone/metabolism/analysis MH - *Child Development/physiology MH - Parenting MH - Memory, Short-Term/physiology MH - Hair/chemistry MH - Cognition/physiology MH - Socioeconomic Factors MH - Poverty MH - Sleep/physiology PMC - PMC13662612 OTO - NOTNLM OT - South Africa OT - executive function OT - preschool OT - socioeconomic status COIS- There is no conflict of interest in this project. EDAT- 2026/10/14 05:34 MHDA- 2026/10/14 05:35 PMCR- 2026/10/14 CRDT- 2026/10/14 04:04 PHST- 2026/08/26 00:00 [revised] PHST- 2025/10/30 00:00 [received] PHST- 2026/09/12 00:00 [accepted] PHST- 2026/10/14 05:35 [medline] PHST- 2026/10/14 05:34 [pubmed] PHST- 2026/10/14 04:04 [entrez] PHST- 2026/10/14 00:00 [pmc-release] AID - DESC70289 [pii] AID - 10.1111/desc.70289 [doi] PST - ppublish SO - Dev Sci. 2026 Nov;29(6):e70289. doi: 10.1111/desc.70289. PMID- 42865672 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261013 LR - 20261014 IS - 2296-4185 (Print) IS - 2296-4185 (Electronic) IS - 2296-4185 (Linking) VI - 14 DP - 2026 TI - Tibiotarsal mechanical behaviour is mainly a function of bone structure and not mineral density in female adolescent chickens. PG - 1812701 LID - 10.3389/fbioe.2026.1812701 [doi] LID - 1812701 AB - INTRODUCTION: Bone fragility and disuse osteoporosis in commercial egg-laying chickens is a major welfare concern. Efforts to address this have focused on eliciting increases in bone mass during growth by raising chickens in more spacious and complex housing systems that motivate increased physical activity. However, it remains unclear how these bone adaptations influence in vivo bone mechanical behaviour in chickens, namely, whole-bone stiffness and strength. METHODS: To investigate this, we sampled female chickens of two genetic strains (Lohmann Brown: brown-feathered, Lohmann LSL Lite: white-feathered) with different loading histories (sedentary: housed in cages with no opportunity for dynamic load bearing activity; active: raised in one of two styles of aviary housing systems requiring locomotion including jumping and other aerial transitions) just prior to the onset of sexual maturity at 16 weeks of age. We imaged their whole right tibiotarsi (ex vivo) using microCT and for the first time developed finite element models of the chicken tibiotarsi under controlled in vivo axial compressive loading on a limited sample size (n = 1, N = 6), which we validated with in vivo strain gauge measurements. Each bone was modelled with both homogeneous and heterogeneous material properties to assess the effects of tissue mineral density and bone structure on the mechanical behaviour. We also quantified a variety of structural measures along the bone length and determined their correlation to simulated mechanical behaviour. RESULTS: We found that consideration of volumetric tissue mineralization heterogeneity in our FE models had negligible influence on the modelled mechanical behaviour, and thus further analyses used only homogeneous FEMs. We identified bone area, total area, bone area ratio, bone thickness, eccentricity, normalized outer perimeter, and inner-to-outer perimeter ratio to be significantly correlated to decreased modelled stress. Increased activity levels was associated with lower modelled stresses in brown-, but not white-feathered chickens, and this pattern could be explained by differences in bone area, total area, and inner-to-outer perimeter ratio. CONCLUSION: These results suggest that, similar to what has been shown in humans, bone structure and not just mineral density is a critical determinant of mechanical behaviour and therefore fracture risk. We identify structural outcomes that can be candidates for genetic selection, targeting improved bone strength, a subset of which may adapt to loading in brown-feathered chickens. We also present a novel (in the poultry science field) approach to assess the relationship between bone structure and mechanical behaviour, which can be further used to inform genetic selection and breeding for improved bone strength and fracture resistance. CI - Copyright (c) 2026 Vitienes, Julien, Rentsch, Main, Widowski, Checa and Willie. FAU - Vitienes, Isabela AU - Vitienes I AD - Department of Biological and Biomedical Engineering, McGill University, Montreal, QC, Canada. AD - Research Centre, Shriners Hospital for Children-Canada, Montreal, QC, Canada. AD - Department of Operative, Preventive and Pediatric Dentistry, Charite - Universitatsmedizin, Berlin, Germany. FAU - Julien, Catherine AU - Julien C AD - Research Centre, Shriners Hospital for Children-Canada, Montreal, QC, Canada. AD - Faculty of Dental Medicine and Oral Health Science, McGill University, Montreal, QC, Canada. FAU - Rentsch, Ana K AU - Rentsch AK AD - Department of Animal Bioscience, University of Guelph, Guelph, ON, Canada. FAU - Main, Russell P AU - Main RP AD - Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States. AD - Department of Basic Medical Sciences, Purdue University, Purdue, IN, United States. FAU - Widowski, Tina M AU - Widowski TM AD - Department of Animal Bioscience, University of Guelph, Guelph, ON, Canada. FAU - Checa, Sara AU - Checa S AD - Julius Wolff Institute, Charite-Universitatsmedizin Berlin, Berlin, Germany. AD - Institute of Biomechanics, Hamburg University of Technology (TUHH), Hamburg, Germany. FAU - Willie, Bettina M AU - Willie BM AD - Research Centre, Shriners Hospital for Children-Canada, Montreal, QC, Canada. AD - Faculty of Dental Medicine and Oral Health Science, McGill University, Montreal, QC, Canada. AD - College of Veterinary Medicine, Utah State University, Logan, UT, United States. LA - eng PT - Journal Article DEP - 20260928 PL - Switzerland TA - Front Bioeng Biotechnol JT - Frontiers in bioengineering and biotechnology JID - 101632513 PMC - PMC13655523 OTO - NOTNLM OT - bone adaptation OT - bone fragility OT - bone mechanical behaviour OT - bone structure OT - egg-laying hens COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/13 11:41 MHDA- 2026/10/13 11:42 PMCR- 2026/09/28 CRDT- 2026/10/13 09:30 PHST- 2026/02/17 00:00 [received] PHST- 2026/07/15 00:00 [revised] PHST- 2026/07/30 00:00 [accepted] PHST- 2026/10/13 11:42 [medline] PHST- 2026/10/13 11:41 [pubmed] PHST- 2026/10/13 09:30 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - 1812701 [pii] AID - 10.3389/fbioe.2026.1812701 [doi] PST - epublish SO - Front Bioeng Biotechnol. 2026 Sep 28;14:1812701. doi: 10.3389/fbioe.2026.1812701. eCollection 2026. PMID- 42865446 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261014 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - A data-driven stratification framework for physical fitness in junior high school students: a composite approach based on BMI and multidimensional data. PG - 1959431 LID - 10.3389/fpubh.2026.1959431 [doi] LID - 1959431 AB - OBJECTIVE: To overcome the practical challenges of implementing differentiated instruction in large physical education (PE) classes, this study develops a composite stratification framework. This exploratory framework provides a baseline for precise, individualized physical fitness interventions in adolescents. METHODS: A quantitative cross-sectional design was employed. First, a questionnaire survey was administered to 125 primary and secondary school PE teachers in Beijing to evaluate their attitudes and preferences for evaluation indicators regarding differentiated instruction. Second, multidimensional physical fitness monitoring data were collected from 532 junior high school students. Following the standardization of continuous physical fitness test scores and categorization by Body Mass Index (BMI), one-way analysis of variance (ANOVA) and K-means clustering algorithms were comprehensively applied to explore the underlying latent cluster formations of students' multidimensional physical fitness characteristics. RESULTS: The survey revealed a high theoretical acceptance of differentiated instruction among frontline teachers, yet a "knowing-doing gap" remains in large-class settings, with 65.85% of respondents prioritizing BMI as the primary stratification criterion. ANOVA confirmed significant differences in physical fitness scores across BMI groups, validating its preliminary screening value. However, it also demonstrated that relying on a single morphological indicator easily obscures the micro-heterogeneity of unbalanced physical performance. The introduction of multidimensional data clustering successfully grouped male students into 2 clusters and female students into 3 clusters, effectively controlling pedagogical stratification tiers and intra-group variance. CONCLUSION: The composite stratification framework-integrating initial BMI screening with multidimensional physical fitness data clustering-serves as an exploratory framework for identifying heterogeneous fitness profiles. Because this study identifies statistical subgroups cross-sectionally without prospective interventions or safety monitoring, it does not constitute a validated educational strategy. Its practical pedagogical effectiveness, longitudinal stability, and safety require rigorous external validation studies. CI - Copyright (c) 2026 Fang, Hou and Wen. FAU - Fang, Yi AU - Fang Y AD - Capital University of Physical Education and Sports, Beijing, China. FAU - Hou, Juhao AU - Hou J AD - Capital University of Physical Education and Sports, Beijing, China. FAU - Wen, Shilin AU - Wen S AD - Capital University of Physical Education and Sports, Beijing, China. LA - eng PT - Journal Article DEP - 20260928 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - *Physical Fitness/physiology MH - Humans MH - *Body Mass Index MH - Cross-Sectional Studies MH - *Physical Education and Training MH - Female MH - Male MH - Adolescent MH - Clustering Algorithms MH - Surveys and Questionnaires MH - *Students/statistics & numerical data MH - Cluster Analysis MH - Beijing PMC - PMC13654965 OTO - NOTNLM OT - adolescent health OT - body mass index (BMI) OT - cluster analysis OT - differentiated instruction OT - physical fitness COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/13 11:41 MHDA- 2026/10/13 11:42 PMCR- 2026/09/28 CRDT- 2026/10/13 06:43 PHST- 2026/08/05 00:00 [received] PHST- 2026/09/04 00:00 [revised] PHST- 2026/09/10 00:00 [accepted] PHST- 2026/10/13 11:42 [medline] PHST- 2026/10/13 11:41 [pubmed] PHST- 2026/10/13 06:43 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1959431 [doi] PST - epublish SO - Front Public Health. 2026 Sep 28;14:1959431. doi: 10.3389/fpubh.2026.1959431. eCollection 2026. PMID- 42865444 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261015 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Physical activity, entertainment screen time, and dietary fat profiles and concurrent weight status among school-attending Chinese children and adolescents: CHNS 2004-2011. PG - 1945546 LID - 10.3389/fpubh.2026.1945546 [doi] LID - 1945546 AB - BACKGROUND: Physical activity, screen-based leisure, and diet co-occur, but profiles estimated from a small set of indicators may be sensitive to historical period and model assumptions. We identified profiles defined by total physical activity, reported entertainment screen time, and dietary fat contribution to energy intake in the 2004-2011 China Health and Nutrition Survey (CHNS), and examined their concurrent associations with weight status. METHODS: This pooled cross-sectional analysis included 4,112 person-wave observations from school-attending participants aged 6-17 years. A prespecified Gaussian mixture analysis compared one through six profiles. Associations with measured overweight/obesity were estimated in 4,068 observations from 2,757 participants using posterior-probability pseudo-class draws and participant-clustered robust standard errors. Wave-, age-, model-specification-, missing-data-, and alternative-outcome analyses assessed robustness. RESULTS: The prespecified model retained five profiles: very low activity (6.9%), low-to-moderate activity/lower fat (37.8%), no reported entertainment screen time (5.4%), higher fat (27.8%), and highly active (22.2%). The exact BIC-preferred number of profiles varied across survey waves, age groups, and model specifications, and 48.4% of observations had a maximum posterior probability below 0.70. The estimated prevalence of overweight/obesity, accounting for profile-membership uncertainty, was highest in the very-low-activity profile (24.4%) and was 16.4% in the reference profile. This descriptive difference attenuated after adjustment (odds ratio, 1.18; 95% confidence interval, 0.81-1.69), and the fully adjusted global profile test was non-significant (p = 0.806). Multinomial models separating overweight and obesity, continuous BMI and approximate WHO BMI-for-age z-score models, multiple imputation, and inverse-probability weighting produced the same overall conclusion. CONCLUSION: In the 2004-2011 CHNS analytic sample, the measured behaviors formed heterogeneous combinations, but the selected profiles did not independently distinguish concurrent weight status after adjustment. The findings are historical and sample-specific; they should not be interpreted as current national profile distributions or as validation of profile-based interventions. CI - Copyright (c) 2026 Qin, Wang, Zhang, Sheng, Jiang, Cheng and Wang. FAU - Qin, Boao AU - Qin B AD - School of Physical Education, Yanshan University, Qinhuangdao, China. FAU - Wang, Changyang AU - Wang C AD - School of Physical Education, Yanshan University, Qinhuangdao, China. FAU - Zhang, Yuchen AU - Zhang Y AD - School of Physical Education, Yanshan University, Qinhuangdao, China. FAU - Sheng, Linwei AU - Sheng L AD - School of Physical Education, Yanshan University, Qinhuangdao, China. FAU - Jiang, Xiaobo AU - Jiang X AD - School of Physical Education, Yanshan University, Qinhuangdao, China. FAU - Cheng, Chen AU - Cheng C AD - School of Physical Education, Yanshan University, Qinhuangdao, China. FAU - Wang, Yukuo AU - Wang Y AD - School of Physical Education, Yanshan University, Qinhuangdao, China. LA - eng GR - R01 HD030880/HD/NICHD NIH HHS/United States GR - R01 DK104371/DK/NIDDK NIH HHS/United States GR - R01 AG065357/AG/NIA NIH HHS/United States GR - R01 HL108427/HL/NHLBI NIH HHS/United States GR - D43 TW009077/TW/FIC NIH HHS/United States PT - Journal Article DEP - 20260928 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - 0 (Dietary Fats) RN - Chinese people SB - IM MH - Humans MH - Child MH - *Screen Time MH - China/epidemiology MH - Adolescent MH - Female MH - Cross-Sectional Studies MH - Male MH - Nutrition Surveys MH - *Exercise MH - *Dietary Fats/administration & dosage MH - Overweight/epidemiology MH - *Body Weight MH - East Asian People PMC - PMC13654989 OTO - NOTNLM OT - China Health and Nutrition Survey OT - behavioral profiles OT - children and adolescents OT - dietary fat OT - entertainment screen time OT - latent profile analysis OT - physical activity OT - weight status COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/13 11:41 MHDA- 2026/10/13 11:42 PMCR- 2026/09/28 CRDT- 2026/10/13 06:39 PHST- 2026/07/22 00:00 [received] PHST- 2026/08/12 00:00 [revised] PHST- 2026/08/18 00:00 [accepted] PHST- 2026/10/13 11:42 [medline] PHST- 2026/10/13 11:41 [pubmed] PHST- 2026/10/13 06:39 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1945546 [doi] PST - epublish SO - Front Public Health. 2026 Sep 28;14:1945546. doi: 10.3389/fpubh.2026.1945546. eCollection 2026. PMID- 42865130 OWN - NLM STAT- Publisher LR - 20261022 IS - 1536-4801 (Electronic) IS - 0277-2116 (Linking) DP - 2026 Oct 12 TI - Early lactation breast milk protein and lactose as independent predictors of infant regurgitation: A prospective cohort study. LID - 10.1002/jpn3.70600 [doi] AB - OBJECTIVES: To examine whether breast milk (BM) macronutrient composition in the first 2 weeks postpartum is associated with subsequent infant regurgitation (IR) risk, independent of maternal dietary intake. METHODS: In this prospective cohort study (Beijing, China), 78 mother-infant dyads were followed for 5 months. BM samples were collected at 1-2 weeks, 1, 2, and 5 months postpartum. IR was diagnosed using Rome IV criteria. Macronutrient composition (protein, fat, lactose) was analyzed using standardized methods. Maternal diet was assessed via a validated food frequency questionnaire. Multivariable logistic regression adjusted for maternal (body mass index, gestational age) and infant (birth weight, gender) characteristics. RESULTS: IR incidence peaked at 1 month (61.5%) and declined thereafter. Compared with controls, infants who developed IR at 1-2 months were exposed to lower protein and higher lactose concentrations in BM collected at 1-2 weeks (p < 0.05 for both). Maternal dietary intake was not associated with BM macronutrient composition. In adjusted models, lower early BM protein (odds ratio [OR] 0.090; 95% confidence interval [CI] 0.012-0.670) and higher lactose (OR 2.571; 95% CI 1.039-6.363) were associated with increased IR risk at 1 month. CONCLUSIONS: Early BM composition may be associated with subsequent IR risk, independent of maternal diet. Protein and lactose levels in early lactation may serve as potential markers for identifying infants at risk. These findings suggest early lactation as a sensitive period linking maternal physiology to infant gastrointestinal outcomes. CI - (c) 2026 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Li, Pei AU - Li P AD - School of Public Health, Capital Medical University, Beijing, China. AD - Beijing Luhe Hospital, Capital Medical University, Beijing, China. FAU - Wu, Dan AU - Wu D AD - Beijing Luhe Hospital, Capital Medical University, Beijing, China. FAU - Jiang, Yilun AU - Jiang Y AUID- ORCID: 0009-0008-1232-0171 AD - School of Public Health, Capital Medical University, Beijing, China. AD - Beijing Key Laboratory of Environment and Aging, Beijing, China. FAU - Lu, Shuangmei AU - Lu S AD - Beijing Luhe Hospital, Capital Medical University, Beijing, China. FAU - Peng, Jing AU - Peng J AD - Beijing Luhe Hospital, Capital Medical University, Beijing, China. FAU - Yang, Chun AU - Yang C AD - School of Public Health, Capital Medical University, Beijing, China. AD - Beijing Key Laboratory of Environment and Aging, Beijing, China. FAU - Li, Peng-Gao AU - Li PG AUID- ORCID: 0000-0001-9134-5116 AD - School of Public Health, Capital Medical University, Beijing, China. AD - Beijing Key Laboratory of Environment and Aging, Beijing, China. LA - eng GR - CNS-Feihe2021-42/Chinese Nutrition Society/ PT - Journal Article DEP - 20261012 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM OTO - NOTNLM OT - early life nutrition OT - gastrointestinal symptoms OT - infant feeding OT - maternal diet OT - risk factors EDAT- 2026/10/13 05:31 MHDA- 2026/10/13 05:31 CRDT- 2026/10/13 03:03 PHST- 2026/07/29 00:00 [revised] PHST- 2026/04/20 00:00 [received] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/10/13 05:31 [pubmed] PHST- 2026/10/13 05:31 [medline] PHST- 2026/10/13 03:03 [entrez] AID - 10.1002/jpn3.70600 [doi] PST - aheadofprint SO - J Pediatr Gastroenterol Nutr. 2026 Oct 12. doi: 10.1002/jpn3.70600. PMID- 42864684 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261015 IS - 2049-9957 (Electronic) IS - 2095-5162 (Print) IS - 2049-9957 (Linking) VI - 15 IP - 1 DP - 2026 Oct 12 TI - Pragmatic weight estimation for dosing of a new paediatric treatment for schistosomiasis prevention and control in preschool-aged children: a feasibility study in Uganda and Cote d'Ivoire. LID - 10.1186/s40249-026-01507-9 [doi] LID - 108 AB - BACKGROUND: Schistosomiasis remains a major public health concern in endemic settings. The Pediatric Praziquantel Consortium has developed a new paediatric treatment, arpraziquantel, for preschool-aged children. Because the treatment is dosed according to body weight, dose determination by scales poses operational challenges in community-based mass treatment campaigns. This study assessed the performance of the Pediatric Advanced Weight Prediction in the Emergency Room Extra-Long Mid-Arm Circumference (PAWPER XL-MAC) tape for weight estimation during mass drug administration in Uganda and Cote d'Ivoire. METHODS: A mixed-methods study evaluated feasibility in terms of accuracy, reliability and acceptability of the PAWPER XL-MAC tape across delivery platforms and users between March 2025 and March 2026. Accuracy metrics comprised (1) the mean relative difference and mean absolute relative difference between predicted (tape) and observed (scale) weight and (2) the proportion of estimates within 10% (PW10) and 20% (PW20) of observed weight. Reliability was evaluated by calculating the intraclass-correlation coefficient (ICC). User experiences were collected through observations, questionnaires, focus group discussions and in-depth interviews. RESULTS: In Uganda (n = 3369), mean absolute differences were 11.0-11.1%; PW10 60.2-61.0%. In Cote d'Ivoire (n = 1249), accuracy was higher (6.8-7.7%; PW10 72.4-78.2%). Reliability was high between users and countries (ICCs >/= 0.84). Sufficient time for practical training was essential to achieve solid performance. With continued use, an increase in confidence, efficiency, and accuracy was observed. Qualitative results indicated strong acceptability and practical advantages amongst users. CONCLUSIONS: This is the first study to demonstrate that the PAWPER XL-MAC tape offers reliable, accurate, and acceptable weight estimation for community-based interventions, supporting its use in routine child healthcare and public health programmes. Trial registration ClinicalTrials.gov ID NCT06698510, date of registration: 21.11.2024. CI - (c) 2026. The Author(s). FAU - Monnier, Nora AU - Monnier N AUID- ORCID: 0000-0001-5140-8549 AD - Swiss Tropical and Public Health Institute, Allschwil, Switzerland. nora.monnier@swisstph.ch. AD - University of Basel, Basel, Switzerland. nora.monnier@swisstph.ch. AD - Swiss Tropical and Public Health Institute, Kreuzstrasse 2, CH-4123, Allschwil, Switzerland. nora.monnier@swisstph.ch. FAU - Beinamaryo, Prudence AU - Beinamaryo P AD - Vector Control Division, Ministry of Health Uganda, Kampala, Uganda. FAU - Wells, Mike AU - Wells M AD - Division of Emergency Medicine, University of the Witwatersrand, Johannesburg, South Africa. AD - Jackson Memorial Hospital, Miami, FL, USA. FAU - Akoa, Agathe AU - Akoa A AD - Programme National de Nutrition, Ministere de la Sante, de l'Hygiene et de la Couverture Maladie Universelle, Abidjan, Cote d'Ivoire. FAU - Aritnaitwe, Moses AU - Aritnaitwe M AD - Vector Control Division, Ministry of Health Uganda, Kampala, Uganda. FAU - Barth-Jaeggi, Tanja AU - Barth-Jaeggi T AD - Swiss Tropical and Public Health Institute, Allschwil, Switzerland. AD - University of Basel, Basel, Switzerland. FAU - Bassa, Fidele K AU - Bassa FK AD - UFR Biosciences, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. AD - Centre Suisse de Recherches Scientifiques en Cote d'Ivoire, Abidjan, Cote d'Ivoire. FAU - Burrill, Jenny AU - Burrill J AD - Unlimit Health, London, UK. FAU - Coulibaly, Gaoussou AU - Coulibaly G AD - UFR Biosciences, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. AD - Centre Suisse de Recherches Scientifiques en Cote d'Ivoire, Abidjan, Cote d'Ivoire. FAU - Diakite, Nana R AU - Diakite NR AD - UFR Biosciences, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. AD - Centre Suisse de Recherches Scientifiques en Cote d'Ivoire, Abidjan, Cote d'Ivoire. FAU - Dje, Norbert N AU - Dje NN AD - Programme National de Lutte Contre les Maladies Tropicales Negligees a Chimiotherapie Preventive, Ministere de la Sante, de l'Hygiene Publique et de la Couverture Maladie Universelle, Abidjan, Cote d'Ivoire. FAU - Gnahore, Alexise D AU - Gnahore AD AD - Departement de Sociologie, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. FAU - Hattendorf, Jan AU - Hattendorf J AD - Swiss Tropical and Public Health Institute, Allschwil, Switzerland. AD - University of Basel, Basel, Switzerland. FAU - Hurlimann, Eveline AU - Hurlimann E AD - Swiss Tropical and Public Health Institute, Allschwil, Switzerland. AD - University of Basel, Basel, Switzerland. FAU - Kouame, Rene O AU - Kouame RO AD - Programme National de Nutrition, Ministere de la Sante, de l'Hygiene et de la Couverture Maladie Universelle, Abidjan, Cote d'Ivoire. FAU - Kouamin, Alain C AU - Kouamin AC AD - Programme National de Lutte Contre les Maladies Tropicales Negligees a Chimiotherapie Preventive, Ministere de la Sante, de l'Hygiene Publique et de la Couverture Maladie Universelle, Abidjan, Cote d'Ivoire. FAU - Kyarisiima, Hilda AU - Kyarisiima H AD - Vector Control Division, Ministry of Health Uganda, Kampala, Uganda. FAU - Lange, Isabelle L AU - Lange IL AD - Department of Neurology, TUM University Hospital and Center for Global Health, School of Medicine and Health, Technical University of Munich, Munich, Germany. AD - Department of Infectious Disease Epidemiology and International Health, London School of Hygiene & Tropical Medicine, London, UK. FAU - Lavry, Suzanne Lobohon AU - Lavry SL AD - Departement de Sociologie, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. FAU - Nabatte, Betty AU - Nabatte B AD - Vector Control Division, Ministry of Health Uganda, Kampala, Uganda. FAU - Neema, Stella AU - Neema S AD - Department of Sociology and Anthropology, Makerere University, Kampala, Uganda. FAU - N'Goran, Eliezer K AU - N'Goran EK AD - UFR Biosciences, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. AD - Centre Suisse de Recherches Scientifiques en Cote d'Ivoire, Abidjan, Cote d'Ivoire. FAU - N'Goran, Hahyat R AU - N'Goran HR AD - Programme National de Lutte Contre les Maladies Tropicales Negligees a Chimiotherapie Preventive, Ministere de la Sante, de l'Hygiene Publique et de la Couverture Maladie Universelle, Abidjan, Cote d'Ivoire. FAU - Ohouo, Ulrich AU - Ohouo U AD - Programme National de Nutrition, Ministere de la Sante, de l'Hygiene et de la Couverture Maladie Universelle, Abidjan, Cote d'Ivoire. FAU - Preston, Ashley AU - Preston A AD - UFR Biosciences, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. FAU - Roth, Laura F AU - Roth LF AD - Department of Neurology, TUM University Hospital and Center for Global Health, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Sehi Bi, Tra J AU - Sehi Bi TJ AD - Departement de Sociologie, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. FAU - Verhoeven, Dianne AU - Verhoeven D AD - Department of Neurology, TUM University Hospital and Center for Global Health, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Winkler, Andrea S AU - Winkler AS AD - Department of Neurology, TUM University Hospital and Center for Global Health, School of Medicine and Health, Technical University of Munich, Munich, Germany. AD - Department of Community Medicine and Global Health, Institute of Health and Society, University of Oslo, Oslo, Norway. FAU - Toh, Alain AU - Toh A AD - Departement de Sociologie, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. FAU - Steinmann, Peter AU - Steinmann P AD - Swiss Tropical and Public Health Institute, Allschwil, Switzerland. AD - University of Basel, Basel, Switzerland. FAU - Ouattara, Mamadou AU - Ouattara M AD - UFR Biosciences, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. AD - Centre Suisse de Recherches Scientifiques en Cote d'Ivoire, Abidjan, Cote d'Ivoire. CN - Pediatric Praziquantel Consortium LA - eng SI - ClinicalTrials.gov/NCT06698510 GR - G2020-102/Global Health Innovation Technology Fund/ GR - RIA2019IR-2895./EDCTP/ PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20261012 PL - England TA - Infect Dis Poverty JT - Infectious diseases of poverty JID - 101606645 RN - 0 (Anthelmintics) RN - 6490C9U457 (Praziquantel) SB - IM MH - Child, Preschool MH - Female MH - Humans MH - Male MH - *Anthelmintics/administration & dosage MH - *Body Weight MH - Cote d'Ivoire/epidemiology MH - Feasibility Studies MH - *Mass Drug Administration MH - *Praziquantel/administration & dosage/therapeutic use MH - Reproducibility of Results MH - *Schistosomiasis/prevention & control/drug therapy MH - Uganda/epidemiology PMC - PMC13660070 OTO - NOTNLM OT - Arpraziquantel OT - Child health OT - Implementation research OT - Neglected tropical diseases OT - Pediatric drug dosing OT - Preschool-aged children OT - Schistosomiasis OT - Weight estimation COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the ethical principles of the Declaration of Helsinki and scientific standards for research involving human participants. The study in Uganda was approved by the Ugandan National Council for Science and Technology (UNCST, Ref: HS5146ES), the Vector Control Division Research Ethics Committee (VCDR-2024-60) and the Ethics Committee Northwest and Central Switzerland (EKNZ, AO_2024-10-00103). Authorization to conduct research in Bugiri and Hoima Districts was given by the local governments in each district. The study in Cote d'Ivoire was approved by the National Ethics Committee of Cote d'Ivoire (Comite National d'Ethique des Sciences de la Vie et de la Sante CNESVS, N/Ref: 00215-25/MSHPCMU/CNESVS-km) and EKNZ (AO_2025-00121). The social science study for pilot implementation in Uganda was approved by the Ethics Committee of the Technical University of Munich (TUM), University Hospital (TUM, 2024-394-S-CB), Germany, the Makerere University School of Social Science Research Ethics Committee (MAKSSREC 07.2024.766) and the UNCST (SS3420ES). The social science study in the large-scale study distribution in Cote d'Ivoire was approved by the Ethics Committee of TUM (2025-623-S-CT) and by the CNESVS (N/Ref: 00188-25/MSHPCMU/CNESVS-km) of Cote d'Ivoire. All participants, or the parents/legal guardians of minors, provided informed consent prior to enrolment. No biological samples were collected. Consent for publication: Not applicable. Patient and public involvement: Patients or the public were not involved in the design, or conduct, or reporting, or dissemination plans of our research. Competing interests: The authors declare no competing interests. EDAT- 2026/10/13 05:31 MHDA- 2026/10/13 05:32 PMCR- 2026/10/12 CRDT- 2026/10/13 00:47 PHST- 2026/06/02 00:00 [received] PHST- 2026/09/17 00:00 [accepted] PHST- 2026/10/13 05:32 [medline] PHST- 2026/10/13 05:31 [pubmed] PHST- 2026/10/13 00:47 [entrez] PHST- 2026/10/12 00:00 [pmc-release] AID - 10.1186/s40249-026-01507-9 [pii] AID - 1507 [pii] AID - 10.1186/s40249-026-01507-9 [doi] PST - epublish SO - Infect Dis Poverty. 2026 Oct 12;15(1):108. doi: 10.1186/s40249-026-01507-9. PMID- 42864118 OWN - NLM STAT- In-Process LR - 20261016 IS - 2755-9734 (Electronic) IS - 2755-9734 (Linking) VI - 29 IP - 1 DP - 2026 Oct 12 TI - Psychological and anthropometric outcomes in preschool children exposed to antenatal maternal obesity: modelling of early life risk factors. LID - 10.1136/bmjment-2026-302738 [doi] LID - e302738 AB - BACKGROUND: Maternal obesity is associated with increased risk of adverse neurodevelopmental outcomes and obesity in offspring, yet their comorbidity among preschoolers and underlying mechanisms remain unclear. OBJECTIVE: To examine associations between maternal obesity in pregnancy and offspring preschool psychopathology, focusing on clinical and biological pathways. METHODS: In a cohort of 462 women with obesity in pregnancy (body mass index (BMI) >/=30 kg/m(2)) from the UK Pregnancies Better Eating and Activity Trial, followed up with their children at 3-4 years postpartum (49% boys), structural equation models assessed effects of antenatal exposures (measured at three visits) on child risk of psychopathology: maternal inflammation (by interleukin-6), glycaemia (by random glucose or gestational diabetes diagnosis), placental function (by placental growth factor) and depressive symptoms. Child outcomes were derived from the Strengths and Difficulties Questionnaire scores and psychological phenotypes from latent class analysis (LCA). Child adiposity and eating behaviours were compared across phenotypes. FINDINGS: High-risk of psychopathology was identified in 11.3% of children (boys 14.7%, girls 8%). Higher antenatal maternal depression and lower placental function predicted increased risk of psychopathology, while inflammation and glycaemia were not associated (R(2)=44.5%). LCA identified externalising (8%) and internalising (4.1%) phenotypes. An externalising phenotype was associated with higher BMI, weight-for-age z-scores and waist circumference; both phenotypes showed greater food fussiness than well-adjusted children. CONCLUSIONS: One in 10 children of women with obesity showed early risk of psychopathology, which was linked to adiposity. Antenatal maternal depression emerged as the primary risk factor, with a novel role for placental dysfunction. CLINICAL IMPLICATION: Screening for maternal depression and placental function in pregnancies affected by obesity may help reduce adverse neurodevelopmental and metabolic outcomes in offspring. FAU - Sigurdardottir, Julie AU - Sigurdardottir J AUID- ORCID: 0000-0002-7328-648X AD - Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK julie.nihouarn@kcl.ac.uk. FAU - Dalrymple, Kathryn AU - Dalrymple K AD - Department of Nutritional Sciences, School of Life Course and Population Health Sciences, King's College London, London, UK. FAU - Rutherford, Mary AU - Rutherford M AD - Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK. FAU - Poston, Lucilla AU - Poston L AD - Department of Women and Children's Health, School of Life Course and Population Health Sciences, King's College London, London, UK. CN - UPBEAT Consortium LA - eng PT - Journal Article DEP - 20261012 PL - England TA - BMJ Ment Health JT - BMJ mental health JID - 9918521385306676 SB - IM PMC - PMC13662093 OTO - NOTNLM OT - Attention Deficit and Disruptive Behavior Disorders OT - Child Behavior Disorders OT - Feeding and Eating Disorders of Childhood OT - Psychometrics OT - Psychopathology COIS- Competing interests: None declared. FIR - Poston, Lucilla IR - Poston L FIR - Shennan, Andrew IR - Shennan A FIR - Briley, Annette IR - Briley A FIR - Singh, Claire IR - Singh C FIR - Seed, Paul IR - Seed P FIR - Sandall, Jane IR - Sandall J FIR - Sanders, Thomas IR - Sanders T FIR - Patel, Nashita IR - Patel N FIR - Flynn, Angela IR - Flynn A FIR - Badger, Shirlene IR - Badger S FIR - Barr, Suzanne IR - Barr S FIR - Holmes, Bridget IR - Holmes B FIR - Goff, Louise IR - Goff L FIR - Hunt, Clare IR - Hunt C FIR - Filmer, Judy IR - Filmer J FIR - Fetherstone, Jeni IR - Fetherstone J FIR - Scholtz, Laura IR - Scholtz L FIR - Tarft, Hayley IR - Tarft H FIR - Lucas, Anna IR - Lucas A FIR - Tekletdadik, Tsigerada IR - Tekletdadik T FIR - Ricketts, Deborah IR - Ricketts D FIR - Gill, Carolyn IR - Gill C FIR - Ignatian, Alex Seroge IR - Ignatian AS FIR - Boylen, Catherine IR - Boylen C FIR - Adegoke, Funso IR - Adegoke F FIR - Lawley, Elodie IR - Lawley E FIR - Butler, James IR - Butler J FIR - Maitland, Rahat IR - Maitland R FIR - Vieira, Matias IR - Vieira M FIR - Pasupathy, Dharmintra IR - Pasupathy D FIR - Goff, Louise IR - Goff L FIR - Oteng-Ntim, Eugene IR - Oteng-Ntim E FIR - Khazaezadeh, Nina IR - Khazaezadeh N FIR - Demilew, Jill IR - Demilew J FIR - O'Connor, Sile IR - O'Connor S FIR - Evans, Yvonne IR - Evans Y FIR - O'Donnell, Susan IR - O'Donnell S FIR - Llera, Ari Dela IR - Llera AD FIR - Gutzwiller, Georgina IR - Gutzwiller G FIR - Hagg, Linda IR - Hagg L FIR - Robson, Stephen IR - Robson S FIR - Bell, Ruth IR - Bell R FIR - Hayes, Louise IR - Hayes L FIR - Kinnunen, Tarja IR - Kinnunen T FIR - McParlin, Catherine IR - McParlin C FIR - Miller, Nicola IR - Miller N FIR - Kimber, Alison IR - Kimber A FIR - Riches, Jill IR - Riches J FIR - Allen, Carly IR - Allen C FIR - Boag, Claire IR - Boag C FIR - Campbell, Fiona IR - Campbell F FIR - Fenn, Andrea IR - Fenn A FIR - Ritson, Sarah IR - Ritson S FIR - Rennie, Alison IR - Rennie A FIR - Durkin, Robin IR - Durkin R FIR - Gills, Gayle IR - Gills G FIR - Carr, Roger IR - Carr R FIR - Nelson, Scott IR - Nelson S FIR - Sattar, Naveed IR - Sattar N FIR - McSorley, Therese IR - McSorley T FIR - Alba, Hilary IR - Alba H FIR - Paterson, Kirsteen IR - Paterson K FIR - Johnston, Janet IR - Johnston J FIR - Clements, Suzanne IR - Clements S FIR - Fernon, Maxine IR - Fernon M FIR - Bett, Savannah IR - Bett S FIR - Rooney, Laura IR - Rooney L FIR - Miller, Sinead IR - Miller S FIR - Welsh, Paul IR - Welsh P FIR - Cherry, Lynn IR - Cherry L FIR - Whitworth, Melissa IR - Whitworth M FIR - Patterson, Natalie IR - Patterson N FIR - Lee, Sarah IR - Lee S FIR - Grimshaw, Rachel IR - Grimshaw R FIR - Hughes, Christine IR - Hughes C FIR - Brown, Jay IR - Brown J FIR - Hinshaw, Kim IR - Hinshaw K FIR - Campbell, Gillian IR - Campbell G FIR - Knight, Joanne IR - Knight J FIR - Farrar, Diane IR - Farrar D FIR - Jones, Vicky IR - Jones V FIR - Butterfield, Gillian IR - Butterfield G FIR - Syson, Jennifer IR - Syson J FIR - Eadle, Jennifer IR - Eadle J FIR - Wood, Dawn IR - Wood D FIR - Todd, Merane IR - Todd M FIR - Khalil, Asma IR - Khalil A FIR - Brown, Deborah IR - Brown D FIR - Fernandez, Paola IR - Fernandez P FIR - Cousins, Emma IR - Cousins E FIR - Smith, Melody IR - Smith M FIR - Wardle, Jane IR - Wardle J FIR - Croker, Helen IR - Croker H FIR - Broomfield, Laura IR - Broomfield L FIR - Concern, Weight IR - Concern W FIR - Godfrey, Keith IR - Godfrey K FIR - Robinson, Sian IR - Robinson S FIR - Canadine, Sarah IR - Canadine S FIR - Greenwood, Lynne IR - Greenwood L EDAT- 2026/10/13 00:16 MHDA- 2026/10/13 00:16 PMCR- 2026/10/12 CRDT- 2026/10/12 21:42 PHST- 2026/03/31 00:00 [received] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/13 00:16 [medline] PHST- 2026/10/13 00:16 [pubmed] PHST- 2026/10/12 21:42 [entrez] PHST- 2026/10/12 00:00 [pmc-release] AID - bmjment-2026-302738 [pii] AID - 10.1136/bmjment-2026-302738 [doi] PST - epublish SO - BMJ Ment Health. 2026 Oct 12;29(1):e302738. doi: 10.1136/bmjment-2026-302738. PMID- 42863993 OWN - NLM STAT- Publisher LR - 20261012 IS - 1349-9092 (Electronic) IS - 0917-5040 (Linking) DP - 2026 Oct 9 TI - Relative Validity of Nutrient and Food Group Intakes Estimated From the Brief-type Self-administered Dietary History Questionnaire for Japanese Preschool Children Aged 3-6 Years (BDHQ3y). LID - 10.2188/jea.JE20250707 [doi] AB - BACKGROUND: To evaluate the relative validity of nutrient and food group intakes estimated using the brief-type self-administered Diet History Questionnaire for Japanese preschool children aged 3-6 years (BDHQ3y). METHODS: This study included 500 children (253 boys and 247 girls) aged 3-6 years recruited from 32 prefectures in Japan. Guardians completed the BDHQ3y to report their child's dietary intake over the previous month and then 8-day weighed dietary records (DRs) over a year (2 days per season). From the BDHQ3y and DRs, energy-adjusted intakes of 44 nutrients and 26 food groups were estimated based on the density method. RESULTS: Percentage differences in median intakes were within 10% for 26 nutrients (most energy-providing nutrients and several vitamins and minerals) and three food groups (cereals, fish/shellfish and milk/dairy products). The median Spearman's rank correlation coefficients were 0.31 (interquartile range [IQR], 0.23-0.40) for nutrients and 0.32 (IQR, 0.23-0.41) for food groups. Correlations exceeded 0.40 for 11 nutrients (eg, added sugar, dietary fiber and calcium) and nine food groups (eg, vegetables, fruits and milk/dairy products). Bland-Altman plots showed wide limits of agreement, with overestimation of intakes of protein, fats, carbohydrates, fruits, and milk/dairy products, as well as underestimation of intake of vegetables at higher intake levels. Similar findings were made when boys and girls were analyzed separately. CONCLUSION: The BDHQ3y has the potential to monitor population-level intakes of a range of nutrients. However, its utility for ranking individuals and assessing individual-level intake remains limited, requiring cautious interpretation and application. FAU - Tajima, Ryoko AU - Tajima R AUID- ORCID: 0000-0002-7799-3958 AD - Department of Nutritional Epidemiology and Behavioral Nutrition, Graduate School of Medicine, the University of Tokyo. FAU - Okubo, Hitomi AU - Okubo H AD - Department of Nutritional Epidemiology and Behavioral Nutrition, Graduate School of Medicine, the University of Tokyo. FAU - Shinozaki, Nana AU - Shinozaki N AD - Department of Social and Preventive Epidemiology, School of Public Health, the University of Tokyo. FAU - Masayasu, Shizuko AU - Masayasu S AD - Ikurien-naka. FAU - Sasaki, Satoshi AU - Sasaki S AD - Department of Social and Preventive Epidemiology, School of Public Health, the University of Tokyo. FAU - Murakami, Kentaro AU - Murakami K AD - Department of Social and Preventive Epidemiology, School of Public Health, the University of Tokyo. LA - eng PT - Journal Article DEP - 20261009 PL - Japan TA - J Epidemiol JT - Journal of epidemiology JID - 9607688 SB - IM OTO - NOTNLM OT - Japanese OT - diet history questionnaire OT - food and nutrient intake OT - preschool children OT - relative validity EDAT- 2026/10/13 00:16 MHDA- 2026/10/13 00:16 CRDT- 2026/10/12 21:23 PHST- 2026/10/13 00:16 [medline] PHST- 2026/10/13 00:16 [pubmed] PHST- 2026/10/12 21:23 [entrez] AID - 10.2188/jea.JE20250707 [doi] PST - aheadofprint SO - J Epidemiol. 2026 Oct 9. doi: 10.2188/jea.JE20250707. PMID- 42861691 OWN - NLM STAT- Publisher LR - 20261022 IS - 1536-4801 (Electronic) IS - 0277-2116 (Linking) DP - 2026 Oct 12 TI - Evaluating social validity in practice: Parents' experiences of an eating intervention for children with avoidant restrictive food intake disorder. LID - 10.1002/jpn3.70603 [doi] AB - OBJECTIVES: This study aimed to explore parents' experiences following an eating intervention for children with avoidant/restrictive food intake disorder (ARFID), focusing on the perceived significance of goals, the acceptability of intervention procedures, and the relevance of outcomes within a social validity framework. METHODS: Forty children, meeting criteria for ARFID and referred to a regional multiprofessional eating team were included, along with 67 caregivers. A retrospective mixed-methods design was employed. Quantitative data consisted of parent-reported goal-attainment ratings collected from pre- and post-intervention. Qualitative data were derived from retrospective reviews of medical charts and analyzed using content analysis. The analysis examined the intervention process, documented outcomes, and their alignment with core domains of the social validity framework. RESULTS: Intervention goals were perceived as meaningful and relevant to everyday eating and feeding challenges, and documented experiences reflected varying levels of acceptability and perceived benefit. Analyses showed that parents' visual analogue scale scores were significantly lower following the intervention. Paired-samples t-tests revealed changes in parents' reports of weight concern, mealtime functioning, and concerns about the child's eating from pre- to post-intervention. CONCLUSIONS: The findings underscore the importance of having a holistic and individualized approach to eating interventions. Tailoring interventions to individual family circumstances and priorities may enhance relevance, acceptability, and overall impact. CI - (c) 2026 The Author(s). Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Carlsson, Emilia AU - Carlsson E AUID- ORCID: 0000-0003-2211-823X AD - Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. AD - Institute of Neuroscience and Physiology, Speech and Language Pathology Unit, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Hermansson, Jonas AU - Hermansson J AUID- ORCID: 0000-0002-1091-5576 AD - Department Research and Education, SV Hospital Group, Gothenburg, Sweden. FAU - Linnsand, Petra AU - Linnsand P AUID- ORCID: 0000-0001-8240-6546 AD - Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. AD - Department Research and Education, SV Hospital Group, Gothenburg, Sweden. AD - Child and Adolescent Specialist Centre, Angered Hospital, SV Hospital Group, Gothenburg, Sweden. LA - eng GR - None/ PT - Journal Article DEP - 20261012 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM OTO - NOTNLM OT - eating difficulties OT - parental evaluations OT - pre-school children EDAT- 2026/10/12 11:41 MHDA- 2026/10/12 11:41 CRDT- 2026/10/12 06:42 PHST- 2026/06/25 00:00 [revised] PHST- 2026/03/27 00:00 [received] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/10/12 11:41 [pubmed] PHST- 2026/10/12 11:41 [medline] PHST- 2026/10/12 06:42 [entrez] AID - 10.1002/jpn3.70603 [doi] PST - aheadofprint SO - J Pediatr Gastroenterol Nutr. 2026 Oct 12. doi: 10.1002/jpn3.70603. PMID- 42858697 OWN - NLM STAT- MEDLINE DCOM- 20261028 LR - 20261028 IS - 1532-1983 (Electronic) IS - 0261-5614 (Linking) VI - 66 DP - 2026 Nov TI - Dietary patterns and adverse pregnancy outcomes: Complementary insights from a priori and a posteriori approaches in a prospective cohort. PG - 106812 LID - S0261-5614(26)00239-6 [pii] LID - 10.1016/j.clnu.2026.106812 [doi] AB - BACKGROUND & AIMS: Maternal diet during pregnancy may influence fetal growth, but evidence based on dietary-pattern approaches remains scarce. We characterized prenatal dietary patterns in a pregnancy cohort using two a priori diet-quality indices and an unsupervised a posteriori data-driven approach, and evaluated their associations with gestational and neonatal outcomes, and assessed the overlap between both methodological approaches. METHODS: We analyzed 595 mother-infant dyads from the Nutrition in Early Life and Asthma (NELA) birth cohort. Maternal diet at 19-22 weeks' gestation was assessed using a validated 123-item food frequency questionnaire. Adherence to the Mediterranean diet and to the Planetary Health diet was quantified using the relative Mediterranean Diet score (rMED) and the Planetary Health Diet Index (PHDI). In addition, we used principal components analysis (PCA) on energy-adjusted food groups, and then hierarchical clustering on the retained scores to identify real-world dietary patterns. Multivariable linear regression analysis was used to explore the association between dietary patterns and gestational weight gain (GWG), neonatal birth weight, and head circumference. A multinomial logistic regression model assessed the capacity of a priori indices to predict cluster membership, evaluated through McFadden's pseudo-R(2), overall accuracy, and Cohen's kappa. RESULTS: Five dietary clusters were identified, with the following proportion of the population in each cluster: Cluster I (9.7%), Cluster II (31.1%), Cluster III (46.7%), Cluster IV (11.4%), and Cluster V (1.0%). Cluster II showed the highest adherence to both indices (mean rMED 9.4; mean PHDI 85.6). Cluster IV (second highest adherence) was consistently associated with lower GWG and higher birth weight compared with Cluster II in adjusted models (-1.28 kg; 95% CI -2.55 to -0.02 and 134.4 g; 95% CI 30.42 to 238.4, respectively) but not head circumference. No associations were found for the rest of clusters or rMED and PHDI indexes. The comparison between approaches revealed poor classification accuracy (55.5%), and slight-to-fair agreement (Cohen's kappa = 0.24). CONCLUSION: An empirically derived dietary profile characterized by vegetables, tubers, legumes, and dairy intake, was associated with lower GWG and higher birth weight. The limited agreement between approaches highlights that a priori indices and data-driven methods capture complementary dimensions of diet, supporting their combined use. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Notario Barandiaran, Leyre AU - Notario Barandiaran L AD - Department of Epidemiology, Geisel School of Medicine, Dartmouth College, NH, USA. Electronic address: Leyre.Notario.Barandiaran@dartmouth.edu. FAU - Diaz Coto, Susana AU - Diaz Coto S AD - Department of Orthopaedics, Dartmouth Health. Geisel School of Medicine at Dartmouth, NH, USA. FAU - Martinez Camblor, Pablo AU - Martinez Camblor P AD - Department of Anesthesiology, Dartmouth Health. Geisel School of Medicine at Dartmouth, NH, USA; Faculty of Health Sciences, Universidad Autonoma de Chile, Chile. FAU - Martinez-Gracia, Carmen AU - Martinez-Gracia C AD - Department of Food Science and Technology, Faculty of Veterinary, University of Murcia, Murcia, Spain; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain. FAU - Suarez-Martinez, Clara AU - Suarez-Martinez C AD - Department of Food Science and Technology, Faculty of Veterinary, University of Murcia, Murcia, Spain; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain. FAU - Santaella-Pascual, Marina AU - Santaella-Pascual M AD - Department of Food Science and Technology, Faculty of Veterinary, University of Murcia, Murcia, Spain; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain. FAU - Prieto-Sanchez, M Teresa AU - Prieto-Sanchez MT AD - Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain; Obstetrics and Gynecology Service, Virgen de la Arrixaca University Clinical Hospital, University of Murcia, Murcia, Spain. FAU - Sanchez-Ferrer, Maria Luisa AU - Sanchez-Ferrer ML AD - Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain; Obstetrics and Gynecology Service, Virgen de la Arrixaca University Clinical Hospital, University of Murcia, Murcia, Spain. FAU - Morales, Eva AU - Morales E AD - Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain; Division of Preventive Medicine and Public Health, Department of Public Health Sciences, Faculty of Medicine, University of Murcia, Murcia, Spain; CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. FAU - Karagas, Margaret R AU - Karagas MR AD - Department of Epidemiology, Geisel School of Medicine, Dartmouth College, NH, USA. FAU - Signes-Pastor, Antonio J AU - Signes-Pastor AJ AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Unidad de Epidemiologia de la Nutricion. Universidad Miguel Hernandez, Alicante, Spain; Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Spain. Electronic address: asignes@umh.es. CN - of the NELA Study Group LA - eng PT - Journal Article DEP - 20261005 PL - England TA - Clin Nutr JT - Clinical nutrition (Edinburgh, Scotland) JID - 8309603 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Prospective Studies MH - *Pregnancy Outcome/epidemiology MH - Adult MH - Diet, Mediterranean/statistics & numerical data MH - Infant, Newborn MH - *Maternal Nutritional Physiological Phenomena MH - *Diet/statistics & numerical data/methods/adverse effects MH - Birth Weight MH - Gestational Weight Gain OTO - NOTNLM OT - Birth outcomes OT - Dietary assessment methods OT - Dietary patterns OT - Gestational weight gain OT - Mediterranean diet OT - Planetary health diet COIS- Conflict of interest The authors declare no conflict of interest. EDAT- 2026/10/11 04:08 MHDA- 2026/10/28 23:26 CRDT- 2026/10/10 19:25 PHST- 2026/03/25 00:00 [received] PHST- 2026/09/21 00:00 [revised] PHST- 2026/09/27 00:00 [accepted] PHST- 2026/10/28 23:26 [medline] PHST- 2026/10/11 04:08 [pubmed] PHST- 2026/10/10 19:25 [entrez] AID - S0261-5614(26)00239-6 [pii] AID - 10.1016/j.clnu.2026.106812 [doi] PST - ppublish SO - Clin Nutr. 2026 Nov;66:106812. doi: 10.1016/j.clnu.2026.106812. Epub 2026 Oct 5. PMID- 42858478 OWN - NLM STAT- Publisher LR - 20261010 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 153 DP - 2026 Sep 17 TI - Lean soft tissue and appendicular lean soft tissue in adolescent soccer players: new predictive equations using raw multifrequency impedance analysis data. PG - 113435 LID - S0899-9007(26)00342-4 [pii] LID - 10.1016/j.nut.2026.113435 [doi] AB - BACKGROUND: As determinants of soccer player performance, lean soft tissue (LST) and appendicular lean soft tissue (ALST) require accurate, segment-specific assessment. OBJECTIVE: This study aimed to develop LST and ALST predictive equations from multi-frequency bioelectrical impedance analysis data at 50 and 500 kHz using raw data from an octapolar device and evaluate their predictive performance using dual-energy X-ray absorptiometry as a reference method via split-sample validation. METHODS: Multiple linear regression models were developed using body mass, impedance index, and maturity offset as predictors. Model performance was evaluated using adjusted R(2), standard error of estimate (SEE), root mean square error, mean absolute error, Lin's concordance correlation coefficient (CCC), and Bland-Altman agreement analysis. Participants were randomly allocated into a development (n = 100) and an independent validation subset (n = 49). RESULTS: Predictive performance was comparable between frequencies, with high explanatory power (R(2) for LST = 0.953-0.955; ALST = 0.931-0.932) and low prediction error (SEE  .90). Structural equation modeling with bootstrapped mediation analysis was used to examine the direct and indirect associations between the cognitive dimension and children's physical activity. RESULTS: Declarative knowledge showed a small but significant direct association with the number of active days (beta = .10), with a complementary mediation via motor abilities (beta = .12). Procedural knowledge followed an 'indirect-only pattern' on number of sports and exercises performed via the affective dimension (beta = .09). CONCLUSION: Knowledge showed limited direct associations with physical activity but indirect pathways via physical and affective dimensions, highlighting the potential of embedding cognitive content in active learning experiences. Promoting physical literacy in physical activity settings should address all its dimensions and embed knowledge acquisition within physical activity. CI - (c) 2026 The Society of Chinese Scholars on Exercise Physiology and Fitness. Published by Elsevier B.V. FAU - Schuck, Tizian AU - Schuck T AD - Bayreuth Center of Sport Science, Chair of Social and Health Sciences, University of Bayreuth, Universitatsstrasse 30, Bayreuth, 95447, Germany. AD - Department of Sport Science and Sport, Chair of Education in Sport, Friedrich-Alexander-University of Erlangen-Nurnberg, Gebbertstrasse 123b, Erlangen, 91058, Germany. FAU - Carl, Johannes AU - Carl J AD - Department of Sport and Human Movement Sciences , University of Vienna, Auf der Schmelz 6a, Wien, 1150, Austria. FAU - Tittlbach, Susanne AU - Tittlbach S AD - Bayreuth Center of Sport Science, Chair of Social and Health Sciences, University of Bayreuth, Universitatsstrasse 30, Bayreuth, 95447, Germany. LA - eng PT - Journal Article DEP - 20260923 PL - Singapore TA - J Exerc Sci Fit JT - Journal of exercise science and fitness JID - 101198241 PMC - PMC13651661 OTO - NOTNLM OT - Cognitive dimension OT - Daily behavior OT - Health-related knowledge OT - Mediation analysis COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/11 05:07 MHDA- 2026/10/11 05:08 PMCR- 2026/09/23 CRDT- 2026/10/10 14:30 PHST- 2026/06/07 00:00 [received] PHST- 2026/07/31 00:00 [revised] PHST- 2026/09/14 00:00 [accepted] PHST- 2026/10/11 05:08 [medline] PHST- 2026/10/11 05:07 [pubmed] PHST- 2026/10/10 14:30 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - S1728-869X(26)00085-7 [pii] AID - 200524 [pii] AID - 10.1016/j.jesf.2026.200524 [doi] PST - ppublish SO - J Exerc Sci Fit. 2026 Oct;24(4):200524. doi: 10.1016/j.jesf.2026.200524. Epub 2026 Sep 23. PMID- 42855966 OWN - NLM STAT- MEDLINE DCOM- 20261010 LR - 20261014 IS - 1365-2060 (Electronic) IS - 0785-3890 (Print) IS - 0785-3890 (Linking) VI - 58 IP - 1 DP - 2026 Dec TI - How much of the incremental protocol does a lactate threshold need? Agreement between three-stage and five-stage testing across seven lactate-derived indices in swimmers. PG - 2737006 LID - 10.1080/07853890.2026.2737006 [doi] LID - 2737006 AB - BACKGROUND: Incremental lactate testing is widely used to characterize the lactate-velocity relationship in swimmers, but the highest-intensity stages increase testing burden and may be difficult to execute consistently. OBJECTIVE: To determine whether a five-stage protocol can be reduced to three stages without materially changing seven lactate-derived velocity indices, and whether model complexity affects reconstruction. METHODS: Ninety highly trained swimmers completed a 5 x 200 m freestyle incremental test at 80-100% of 200 m personal-best performance. Stage-4 and stage-5 lactate values were reconstructed from the first three stages using participant-specific linear extrapolation and a long short-term memory (LSTM) model. Seven lactate-derived indices were recalculated and compared with full-protocol values using limits of agreement, typical error, ICC(A,1) and equivalence testing. RESULTS: Lactate reconstruction was inaccurate for both models, yet v@Exp-Dmax showed close agreement with the full protocol (bias -0.008 m.s(-1); limits of agreement -0.023 to +0.007 m.s(-1); ICC 0.988) and met the pre-specified equivalence criterion. The other six indices did not meet equivalence. LSTM provided no advantage over linear extrapolation, and reconstructed v@Exp-Dmax preserved the performance-association pattern observed with the full protocol. CONCLUSIONS: A three-stage protocol may support lower-burden longitudinal monitoring of v@Exp-Dmax, but protocol simplification is index-specific and does not establish physiological threshold validity. FAU - Shen, Yupeng AU - Shen Y AUID- ORCID: 0000-0002-2960-2510 AD - School of physical education and sports science, South China Normal University, Guangzhou, China. FAU - Zou, Xinnuo AU - Zou X AD - School of physical education and sports science, South China Normal University, Guangzhou, China. FAU - Chen, Xiaotong AU - Chen X AUID- ORCID: 0000-0002-9260-9395 AD - School of physical education and sports science, South China Normal University, Guangzhou, China. AD - Sports Academy, Guangzhou College of Commerce, Guangzhou, China. FAU - Wu, Xiaobin AU - Wu X AD - School of Physical Education, Chengdu Sport University, Chengdu, China. LA - eng PT - Journal Article DEP - 20261009 PL - England TA - Ann Med JT - Annals of medicine JID - 8906388 RN - 33X04XA5AT (Lactic Acid) SB - IM MH - Humans MH - *Swimming/physiology MH - *Lactic Acid/blood MH - Male MH - *Exercise Test/methods MH - Female MH - Adolescent MH - *Anaerobic Threshold/physiology MH - *Athletic Performance/physiology MH - Reproducibility of Results PMC - PMC13656679 OTO - NOTNLM OT - Exp-Dmax OT - Lactate threshold OT - incremental testing OT - swimming COIS- No potential conflict of interest was reported by the author(s). EDAT- 2026/10/10 05:32 MHDA- 2026/10/10 05:33 PMCR- 2026/10/09 CRDT- 2026/10/10 02:52 PHST- 2026/10/10 05:33 [medline] PHST- 2026/10/10 05:32 [pubmed] PHST- 2026/10/10 02:52 [entrez] PHST- 2026/10/09 00:00 [pmc-release] AID - 2737006 [pii] AID - 10.1080/07853890.2026.2737006 [doi] PST - ppublish SO - Ann Med. 2026 Dec;58(1):2737006. doi: 10.1080/07853890.2026.2737006. Epub 2026 Oct 9. PMID- 42855587 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261013 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 11 DP - 2026 Oct 9 TI - Obstructive sleep apnoea severity and insulin resistance in children with Prader-Willi Syndrome: the SPISE index as a candidate metabolic marker. LID - 826 [pii] LID - 10.1007/s00431-026-07506-0 [doi] AB - We compared two surrogate markers of insulin sensitivity - the single-point insulin sensitivity estimator (SPISE) and HOMA-IR - and evaluated their associations with OSA severity in children with genetically confirmed PWS and a symptomatic non-syndromic referral group (NSR) with available polysomnography (PSG) and fasting biochemical data. In this single-centre retrospective cross-sectional study, OSA severity was indexed by the obstructive apnoea-hypopnoea index (oAHI), central AHI (cAHI) and oxygen desaturation index (ODI), and caregiver-reported symptoms by the PSQ-SRBD scale. Multivariable models were fitted within the PWS group. Of 458 PSG studies screened, 31 children with PWS and 47 NSR met the inclusion criteria. cAHI was higher in PWS (p < 0.001), and PSQ-SRBD scores were slightly lower, despite a similar oAHI distribution. Within the PWS group, oAHI correlated inversely with SPISE (rho = - 0.378, p = 0.036). In multivariable models adjusted for age, sex, BMI-SDS, and growth hormone therapy, higher oAHI was associated with lower SPISE (B = - 0.154, p = 0.015), whereas the association with ln(HOMA-IR) was borderline (B = 0.081, p = 0.0497). ODI correlated with SPISE (rho = - 0.427, p = 0.017) but not with HOMA-IR (rho = 0.319, p = 0.081). Phase-stratified analyses showed oAHI-SPISE correlations in phases 2 and 3 and an oAHI-HOMA-IR correlation in phase 3. CONCLUSION: In children with PWS, OSA severity was associated with markers of impaired insulin sensitivity. The associations of SPISE with oAHI and ODI support its further investigation as a candidate metabolic correlate of OSA severity. These findings are hypothesis-generating and require validation in larger independent cohorts. WHAT IS KNOWN: * OSA is highly prevalent in PWS. OSA severity is associated with insulin resistance in adults and in non-syndromic children with obesity, but this relationship and the insulin-independent SPISE index have not been evaluated in PWS. WHAT IS NEW: * OSA severity was associated with impaired insulin sensitivity markers in children with PWS. * SPISE, derived from lipids and BMI without fasting insulin, was associated with oAHI and ODI in PWS; it merits further investigation as a candidate metabolic correlate of OSA severity. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Guney, Abdurrahman Zarif AU - Guney AZ AUID- ORCID: 0000-0002-6956-8820 AD - Division of Paediatric Pulmonology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Akpinar, Osman Talha AU - Akpinar OT AUID- ORCID: 0009-0001-6671-7237 AD - Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Gokden, Meltem AU - Gokden M AUID- ORCID: 0000-0002-8284-0788 AD - Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Yilmaz, Furkan AU - Yilmaz F AUID- ORCID: 0000-0001-6459-9647 AD - Division of Paediatric Pulmonology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Korkmaz, Cigdem AU - Korkmaz C AUID- ORCID: 0000-0002-2096-2253 AD - Division of Paediatric Pulmonology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Oztosun, Berrak Nevin AU - Oztosun BN AUID- ORCID: 0000-0001-5649-8045 AD - Division of Paediatric Pulmonology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Collak, Abdulhamit AU - Collak A AUID- ORCID: 0000-0002-0562-0343 AD - Division of Paediatric Pulmonology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Turan, Hande AU - Turan H AUID- ORCID: 0000-0003-0121-3756 AD - Division of Paediatric Endocrinology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Bayramoglu, Elvan AU - Bayramoglu E AUID- ORCID: 0000-0002-6732-8823 AD - Division of Paediatric Endocrinology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Evliyaoglu, Olcay AU - Evliyaoglu O AUID- ORCID: 0000-0003-4851-8637 AD - Division of Paediatric Endocrinology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Kilinc Sakalli, Ayse Ayzit AU - Kilinc Sakalli AA AUID- ORCID: 0000-0002-2879-8910 AD - Division of Paediatric Pulmonology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. kilincayse203@gmail.com. LA - eng PT - Journal Article DEP - 20261009 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Insulin Resistance MH - *Prader-Willi Syndrome/complications/metabolism MH - *Sleep Apnea, Obstructive/diagnosis/etiology MH - Female MH - Cross-Sectional Studies MH - Male MH - Retrospective Studies MH - Polysomnography MH - Severity of Illness Index MH - Biomarkers/blood MH - Child MH - Child, Preschool MH - Adolescent OTO - NOTNLM OT - HOMA-IR OT - Insulin resistance OT - Obstructive sleep apnoea OT - Paediatrics OT - Prader-Willi syndrome OT - SPISE COIS- Declarations. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. This retrospective study was approved by the Istanbul University-Cerrahpasa Clinical Research Ethics Committee (approval date: 24 December 2025; approval no. E-24687260-604.01-1513367). Consent to participate: This was a retrospective study based on de-identified data extracted from existing medical records collected as part of routine clinical care. Formal informed consent was therefore not sought for the retrospective analysis. Consent to publish: Not applicable. The manuscript contains no individual person's identifying data, images, or videos. Competing interests: The authors declare no competing interests. EDAT- 2026/10/10 05:32 MHDA- 2026/10/10 05:33 CRDT- 2026/10/09 23:37 PHST- 2026/06/13 00:00 [received] PHST- 2026/10/05 00:00 [accepted] PHST- 2026/09/26 00:00 [revised] PHST- 2026/10/10 05:33 [medline] PHST- 2026/10/10 05:32 [pubmed] PHST- 2026/10/09 23:37 [entrez] AID - 10.1007/s00431-026-07506-0 [pii] AID - 10.1007/s00431-026-07506-0 [doi] PST - epublish SO - Eur J Pediatr. 2026 Oct 9;185(11):826. doi: 10.1007/s00431-026-07506-0. PMID- 42853568 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261019 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 9 IP - 10 DP - 2026 Oct 1 TI - A Community-Based Behavioral Intervention and Body Mass Index in School-Aged Children: A Cluster Randomized Clinical Trial. PG - e2638188 LID - 10.1001/jamanetworkopen.2026.38188 [doi] LID - e2638188 AB - IMPORTANCE: Childhood obesity remains a major concern in the US, with increases in body mass index (BMI) observed during and after the COVID-19 pandemic. Scalable behavioral interventions are needed to support obesity prevention in community settings. OBJECTIVE: To evaluate the efficacy of a community-based behavioral intervention (H2GO!) on BMI z scores (zBMIs) among school-aged children. DESIGN, SETTING, AND PARTICIPANTS: This cluster randomized clinical trial was conducted from September 2020 to June 2025 across 11 Boys & Girls Club sites in Massachusetts. Sites were pair-matched and randomized to intervention or usual care condition. Participants included children aged 8 to 13 years and their parents or caregivers. INTERVENTION: Twelve group-based sessions delivered in person over 6 weeks by trained Boys & Girls Club staff using behavioral strategies to reduce sugar-sweetened beverage intake and increase water consumption through health sessions, youth-created narratives, and parent-child activities. Comparison sites received usual programming. MAIN OUTCOMES AND MEASURES: Outcomes were assessed at baseline and at 2, 6, and 12 months using intention-to-treat analyses. The primary outcome was 12-month change from baseline in child zBMI, derived from staff-measured height and weight using standardized protocols. Secondary outcomes included child sugar-sweetened beverage and water intake measured using a validated questionnaire. RESULTS: Among 437 child participants (mean [SD] age, 10.1 [1.2] years; 219 girls [50.1%]), 0.2% were American Indian or Alaska Native, 1.8% were Asian, 15.8% were Black or African American, 42.6% were Hispanic or Latino, and 29.5% were White; 297 (68%) were eligible for free or reduced-price lunch. At baseline, 74 children (16.9%) had overweight, and 161 (36.8%) had obesity. From baseline to 12 months, the mean zBMI did not statistically significantly decrease (-0.11 [95% CI, -0.25 to 0.02]) in the intervention group and did not statistically significantly increase (0.08 [95% CI, -0.04 to 0.20]) in the comparison group; however, the estimated between-group difference in the adjusted mean zBMI change from baseline was statistically significant: -0.19 (95% CI, -0.38 to -0.01; P = .04). Between-group differences in sugar-sweetened beverage and water intake were not significant. CONCLUSIONS AND RELEVANCE: In this cluster randomized clinical trial, a community-based behavioral intervention was associated with a statistically significant between-group difference in zBMI change among school-aged children. Findings support the potential of community-based behavioral interventions in obesity prevention. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04265794. FAU - Wang, Monica L AU - Wang ML AD - Department of Community Health Sciences, Boston University School of Public Health, Boston, Massachusetts. AD - Department of Health Policy and Management, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. FAU - Alatorre, Selenne AU - Alatorre S AD - Department of Community Health Sciences, Boston University School of Public Health, Boston, Massachusetts. FAU - Schwarz, Aviva G AU - Schwarz AG AD - Department of Community Health Sciences, Boston University School of Public Health, Boston, Massachusetts. AD - Department of Psychiatry, Boston Medical Center, Boston, Massachusetts. FAU - Weinberg, Janice AU - Weinberg J AD - Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts. FAU - Sprague Martinez, Linda AU - Sprague Martinez L AD - Department of Medicine, University of Connecticut School of Social Work, Hartford. FAU - Aldworth, Jennifer AU - Aldworth J AD - Massachusetts Alliance of Boys & Girls Clubs, Ludlow. FAU - Kadel, Rabindra AU - Kadel R AD - Center for Health Data Science, Boston University School of Public Health, Boston, Massachusetts. FAU - Rosal, Milagros C AU - Rosal MC AD - Department of Population and Quantitative Health Sciences, University of Massachusetts T.H. Chan School of Medicine, Worcester. FAU - Lemon, Stephenie C AU - Lemon SC AD - Department of Population and Quantitative Health Sciences, University of Massachusetts T.H. Chan School of Medicine, Worcester. LA - eng SI - ClinicalTrials.gov/NCT04265794 PT - Journal Article PT - Randomized Controlled Trial DEP - 20261001 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Behavior Therapy/methods MH - *Body Mass Index MH - Massachusetts/epidemiology MH - *Pediatric Obesity/prevention & control MH - Sugar-Sweetened Beverages PMC - PMC13653277 COIS- Conflict of Interest Disclosures: Dr Weinberg reported receiving personal fees for being a data monitoring biostatistician from Janssen and Sanofi outside the submitted work. Ms Aldworth reported receiving a National Institutes of Health (NIH)-funded subaward from Boston University, paid to her institution, during the conduct of the study. Dr Rosal reported receiving grants from the NIH during the conduct of the study. No other disclosures were reported. EDAT- 2026/10/09 17:34 MHDA- 2026/10/09 17:35 PMCR- 2026/10/09 CRDT- 2026/10/09 11:34 PHST- 2026/10/09 17:35 [medline] PHST- 2026/10/09 17:34 [pubmed] PHST- 2026/10/09 11:34 [entrez] PHST- 2026/10/09 00:00 [pmc-release] AID - 2855120 [pii] AID - zoi261028 [pii] AID - 10.1001/jamanetworkopen.2026.38188 [doi] PST - epublish SO - JAMA Netw Open. 2026 Oct 1;9(10):e2638188. doi: 10.1001/jamanetworkopen.2026.38188. PMID- 42853195 OWN - NLM STAT- Publisher LR - 20261009 IS - 1532-5040 (Electronic) IS - 0959-3985 (Linking) DP - 2026 Oct 9 TI - From information to action; co-designing pain neuroscience education for adolescents with low back pain: Focus group insights. PG - 1-20 LID - 10.1080/09593985.2026.2743833 [doi] AB - INTRODUCTION: Low back pain (LBP) is a common health problem among adolescents. Adolescents with pain report higher stress, more school absenteeism, poorer academic performance, and frequent healthcare use. LBP during adolescence may increase the risk of pain in adulthood, underscoring the importance of supporting young people in developing strategies to understand and manage pain. OBJECTIVE: To develop educational material based on pain neuroscience education (PNE) through co-design with adolescents experiencing LBP. METHODS: Adolescents 15-19 years old were recruited to review an initial prototype developed by the authors. Four focus group discussions involving 15 participants were conducted and analyzed using Krueger's analysis framework. The findings guided the development of a refined prototype, which was then further improved through an additional focus group with six participants to validate interpretations and adjust content. RESULTS: Four themes captured adolescents' needs in relation to pain education. Need for recognition: "This is about me" emphasized relatable, back-specific information. Need for practical tools and support: "What can I do myself?" reflected adolescents' desire for actionable strategies. A format that sparks interest: "Otherwise I will stop reading" highlighted the importance of engaging, concise content adapted to young people. The pathway from information to useful support: "It must be easy to find" underlined the value of structure and simple navigation. Participants confirmed the relevance of the prototype and suggested adjustments, which guided further refinement. Based on these insights, the final Back To Move prototype was developed as a complement to healthcare services. CONCLUSION: Adolescents with LBP value PNE that is back-specific, practical, trustworthy, and presented in a format adapted to their preferences. When evidence-based knowledge is combined with language and design tailored to the target group, educational material becomes more engaging and supportive. These findings highlight the importance of involving young people as active co-designers of health information. FAU - Ahlqwist, Anna AU - Ahlqwist A AD - Department of Health and Rehabilitation/Physiotherapy, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Danielsson, Louise AU - Danielsson L AD - Department of Health and Rehabilitation/Physiotherapy, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Lundberg, Mari AU - Lundberg M AD - Back in Motion Research Group, Department of Health Promoting Science, Sophiahemmet University, Stockholm, Sweden. AD - Sahlgrenska Academy, University of Gothenburg Centre for Person-Centred Care (GPCC), Gothenburg, Sweden. AD - Pain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium. FAU - Varkey, Emma AU - Varkey E AD - Department of Health and Rehabilitation/Physiotherapy, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. AD - Department of Occupational Therapy and Physical Therapy, Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden. LA - eng PT - Journal Article DEP - 20261009 PL - England TA - Physiother Theory Pract JT - Physiotherapy theory and practice JID - 9015520 SB - IM OTO - NOTNLM OT - Low back pain OT - adolescents OT - physical activity OT - physical therapy EDAT- 2026/10/09 11:40 MHDA- 2026/10/09 11:40 CRDT- 2026/10/09 10:34 PHST- 2026/10/09 11:40 [medline] PHST- 2026/10/09 11:40 [pubmed] PHST- 2026/10/09 10:34 [entrez] AID - 10.1080/09593985.2026.2743833 [doi] PST - aheadofprint SO - Physiother Theory Pract. 2026 Oct 9:1-20. doi: 10.1080/09593985.2026.2743833. PMID- 42852721 OWN - NLM STAT- Publisher LR - 20261009 IS - 1473-0804 (Electronic) IS - 1369-7137 (Linking) DP - 2026 Oct 9 TI - Non-linear association between body roundness index and menopausal symptoms in perimenopausal and postmenopausal women. PG - 1-9 LID - 10.1080/13697137.2026.2728616 [doi] AB - OBJECTIVE: This study aimed to examine the association between body roundness index (BRI) and menopausal symptoms in Chinese perimenopausal and postmenopausal women. METHOD: The cross-sectional study enrolled 1795 perimenopausal and postmenopausal women aged 40-69 years who attended the Menopause Clinic at Guangdong Women and Children Hospital. Menopausal symptom severity was assessed using the validated Chinese-modified Kupperman Menopause Index (KMI). Multivariable logistic regression and restricted cubic splines were used to estimate odds ratios (ORs) and identify potential thresholds. RESULTS: Overall, 78.8% of participants reported menopausal symptoms, most of which were mild to moderate. Higher BRI was independently associated with higher odds of menopausal symptoms after adjustment for covariates in a multivariable logistic regression model (OR: 1.20, 95% confidence interval [CI]: 1.05-1.38, p = 0.009). Restricted cubic spline analysis revealed a non-linear relationship between BRI and menopausal symptoms (p-value for non-linearity = 0.014), with a data-derived inflection point at 2.571. Among women with BRI exceeding 2.571, the odds of menopausal symptoms increased progressively with rising BRI (OR: 1.34, 95% CI: 1.11-1.62, p = 0.002). Subgroup analyses showed consistent associations across strata (all p-values for interaction > 0.05). CONCLUSION: The BRI may serve as a useful anthropometric marker for identifying midlife women with greater symptom burden, although causal inference requires prospective validation. FAU - Lyu, Xiao AU - Lyu X AUID- ORCID: 0000-0002-4484-629X AD - Department of Women's Health Care, Guangdong Women and Children Hospital, Guangzhou, China. FAU - Chen, Guozhen AU - Chen G AD - Department of Women's Health Care, Guangdong Women and Children Hospital, Guangzhou, China. FAU - Xia, Jianhong AU - Xia J AUID- ORCID: 0000-0001-8150-2667 AD - Department of Women's Health Care, Guangdong Women and Children Hospital, Guangzhou, China. LA - eng PT - Journal Article DEP - 20261009 PL - England TA - Climacteric JT - Climacteric : the journal of the International Menopause Society JID - 9810959 SB - IM OAB - This study explored whether the body roundness index (BRI), a simple measure of body shape based on waist size and height, is associated with menopausal symptoms. Among women attending a menopause clinic in China, higher BRI was linked to an increased likelihood of reporting menopausal symptoms, especially above a certain BRI threshold. Because the study was cross-sectional, it cannot establish that higher BRI causes symptoms, but the results suggest that central body fat may be important when evaluating women during the menopausal transition. OABL- eng OTO - NOTNLM OT - Body roundness index OT - body fat distribution OT - cross-sectional study OT - menopausal symptoms OT - obesity OT - visceral adiposity EDAT- 2026/10/09 11:40 MHDA- 2026/10/09 11:40 CRDT- 2026/10/09 07:55 PHST- 2026/10/09 11:40 [medline] PHST- 2026/10/09 11:40 [pubmed] PHST- 2026/10/09 07:55 [entrez] AID - 10.1080/13697137.2026.2728616 [doi] PST - aheadofprint SO - Climacteric. 2026 Oct 9:1-9. doi: 10.1080/13697137.2026.2728616. PMID- 42849054 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261011 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 Oct 8 TI - Clustering-Based Accelerometer Measures of Physical Activity Patterns in Children With Overweight or Obesity: Baseline Cross-Sectional Methodological Analysis. PG - e87532 LID - 10.2196/87532 [doi] LID - e87532 AB - BACKGROUND: Accelerometers produce high-resolution physical activity data, but commonly used summary measures often reduce these data to total volume, intensity, or variability and may not retain interpretable temporal structure across the day. Cluster-based summaries may provide a way to characterize daily physical activity profiles while preserving information about when activity occurs. OBJECTIVE: This study evaluated whether cluster-derived accelerometer summary measures could represent daily physical activity patterns and explain variation in pediatric cardiometabolic outcomes comparably to traditional accelerometer summary metrics. METHODS: This baseline cross-sectional methodological analysis used data from 268 Latino children with overweight or obesity from low-income families participating in the Stanford GOALS trial. Participants were aged 7 to 11 years old and wore accelerometers for a minimum of 1 week according to study protocol. Valid daily activity profiles were summarized within a 7:00 AM-11:00 PM analytic window using consecutive, nonoverlapping 10-minute intervals. Daily profiles were clustered using unsupervised learning, and participant-level cluster-derived measures were created from the distribution of valid days assigned to each cluster. We compared these measures with traditional accelerometer summaries, including time spent in activity intensity states, Time Active Mean, Time Active Variability, Activity Intensity Mean, and Activity Intensity Variability. Linear regression models were used to evaluate associations with waist circumference, fasting insulin, and fasting triglycerides, adjusting for age and sex. Model performance was compared using R(2) and the Akaike information criterion. RESULTS: Cluster-derived measures explained a comparable proportion of variation in the 3 cardiometabolic outcomes to traditional accelerometer summary metrics. For example, the highest R(2) values among the cluster-derived measures were 25%, 11%, and 6% for waist circumference, fasting insulin, and fasting triglycerides, respectively, compared with 25%, 10%, and 6% for Time Active Mean. No single summary-measure approach consistently yielded the highest R(2) across all 3 outcomes. CONCLUSIONS: Cluster-derived accelerometer measures provide a regression-ready approach for summarizing daily physical activity patterns while preserving interpretable clock-time structure. In this baseline analysis, these measures performed comparably to traditional accelerometer summaries while capturing temporal features not represented by conventional volume- or intensity-based metrics. Future work should evaluate external validation across diverse populations and settings and assess the use of these measures in longitudinal and intervention analyses. CI - (c) Hyatt Moore IV, Thomas N Robinson, Alexandria Jensen, Fatma Gunturkun, K Farish Haydel, Kristopher I Kapphahn, Manisha Desai. Originally published in JMIR Formative Research (https://formative.jmir.org). FAU - Moore Iv, Hyatt AU - Moore Iv H AUID- ORCID: 0000-0001-7866-2280 AD - Naval Postgraduate School, 1 University Circle, Monterey, CA, 93943, United States. AD - Quantitative Science Unit, Stanford University, Stanford, CA, United States. FAU - Robinson, Thomas N AU - Robinson TN AUID- ORCID: 0000-0002-2367-0774 AD - Department of Pediatrics, Stanford Solutions Science Lab and Division of General Pediatrics, Stanford University, Palo Alto, CA, United States. AD - Department of Medicine, Stanford Prevention Research Center, Stanford University, Palo Alto, CA, United States. FAU - Jensen, Alexandria AU - Jensen A AUID- ORCID: 0000-0001-6337-9079 AD - Quantitative Science Unit, Stanford University, Stanford, CA, United States. FAU - Gunturkun, Fatma AU - Gunturkun F AUID- ORCID: 0000-0002-0948-0413 AD - Quantitative Science Unit, Stanford University, Stanford, CA, United States. FAU - Haydel, K Farish AU - Haydel KF AUID- ORCID: 0009-0006-8272-2059 AD - Department of Pediatrics, Stanford Solutions Science Lab and Division of General Pediatrics, Stanford University, Palo Alto, CA, United States. FAU - Kapphahn, Kristopher I AU - Kapphahn KI AUID- ORCID: 0000-0002-5017-8697 AD - Quantitative Science Unit, Stanford University, Stanford, CA, United States. FAU - Desai, Manisha AU - Desai M AUID- ORCID: 0000-0002-6949-2651 AD - Quantitative Science Unit, Stanford University, Stanford, CA, United States. LA - eng GR - U01 HL103629/HL/NHLBI NIH HHS/United States GR - P30 DK116074/DK/NIDDK NIH HHS/United States GR - R01 LM013355/LM/NLM NIH HHS/United States GR - P30 CA124435/CA/NCI NIH HHS/United States GR - UL1 TR003142/TR/NCATS NIH HHS/United States PT - Journal Article DEP - 20261008 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - Child MH - *Accelerometry/methods/statistics & numerical data/instrumentation MH - Cross-Sectional Studies MH - Female MH - Male MH - *Exercise/physiology MH - Cluster Analysis MH - Clustering Algorithms MH - *Overweight MH - *Pediatric Obesity PMC - PMC13649174 OTO - NOTNLM OT - accelerometry OT - cluster analysis OT - obesity OT - pediatric health OT - physical activity OT - unsupervised machine learning OT - waist circumference OT - wearable sensors COIS- Conflicts of Interest: None declared. EDAT- 2026/10/08 23:31 MHDA- 2026/10/08 23:32 PMCR- 2026/10/08 CRDT- 2026/10/08 17:22 PHST- 2025/11/10 00:00 [received] PHST- 2026/08/28 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/08 23:32 [medline] PHST- 2026/10/08 23:31 [pubmed] PHST- 2026/10/08 17:22 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - v10i1e87532 [pii] AID - 87532 [pii] AID - 10.2196/87532 [doi] PST - epublish SO - JMIR Form Res. 2026 Oct 8;10:e87532. doi: 10.2196/87532. PMID- 42848828 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261010 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 10 DP - 2026 TI - Broader factors associated with current adolescent overweight/obesity status in YRBSS 2023: Survey-aware analysis and calibrated AI-assisted classification. PG - e0360155 LID - 10.1371/journal.pone.0360155 [doi] LID - e0360155 AB - Adolescent overweight and obesity are shaped by demographic, behavioral and psychosocial factors, but it remains unclear whether broader predictor information improves cross-sectional classification of current overweight/obesity status more consistently than changing the machine-learning algorithm. This cross-sectional secondary analysis used 2023 Youth Risk Behavior Surveillance System data from 17,814 United States adolescents aged 12-18 years. Survey-aware multivariable logistic regression was used to identify independent correlates, while Random Forest and XGBoost were evaluated under base and extended predictor frameworks. Models were assessed on a held-out test set for discrimination, threshold-dependent performance, calibration and interpretability. The prevalence of overweight/obesity was 31.8%. Male sex and Black or African American and Hispanic/Latino race/ethnicity were associated with higher odds of overweight/obesity, whereas higher moderate-to-vigorous physical activity and more frequent breakfast intake were associated with lower odds. Extended models outperformed their corresponding base models: ROC-AUC increased from 0.6241 to 0.6894 for Random Forest and from 0.6217 to 0.6724 for XGBoost. RF-Extended was selected for calibration and interpretation. Isotonic recalibration preserved discrimination while improving probability reliability, reducing the Brier score from 0.2126 to 0.1960 and expected calibration error from 0.1160 to 0.0213. Exploratory SHAP analysis identified sex, race/ethnicity, physical activity, sleep duration, age and breakfast frequency among the features contributing most strongly to RF-Extended output. Because predictors and BMI status were measured during the same survey cycle, the models classify current status and should not be interpreted as predicting future obesity. Any screening or prevention application, including potential use in Vietnamese adolescent populations, would require prospective and external validation. CI - Copyright: (c) 2026 Thanh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Thanh, Thu Hoang AU - Thanh TH AD - University of Economics, Ho Chi Minh City, Vietnam. FAU - Thi, Nhan Nguyen AU - Thi NN AD - Department of Midwifery, Faculty of Nursing and Medical Technology, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam. FAU - Nguyen Khac, Toan AU - Nguyen Khac T AUID- ORCID: 0009-0009-7855-2044 AD - Institute of Intelligent and Interactive Technologies, University of Economics, Ho Chi Minh City, Vietnam. LA - eng PT - Journal Article DEP - 20261008 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Male MH - Adolescent MH - Female MH - Boosting Machine Learning Algorithms MH - Random Forest MH - Cross-Sectional Studies MH - United States/epidemiology MH - *Pediatric Obesity/epidemiology MH - Child MH - Classification Algorithms MH - Machine Learning MH - *Overweight/epidemiology MH - Logistic Models PMC - PMC13649136 COIS- The authors have declared that no competing interests exist. EDAT- 2026/10/08 17:35 MHDA- 2026/10/08 17:36 PMCR- 2026/10/08 CRDT- 2026/10/08 16:36 PHST- 2026/05/02 00:00 [received] PHST- 2026/09/23 00:00 [accepted] PHST- 2026/10/08 17:36 [medline] PHST- 2026/10/08 17:35 [pubmed] PHST- 2026/10/08 16:36 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - PONE-D-26-21418 [pii] AID - 10.1371/journal.pone.0360155 [doi] PST - epublish SO - PLoS One. 2026 Oct 8;21(10):e0360155. doi: 10.1371/journal.pone.0360155. eCollection 2026. PMID- 42847480 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261010 IS - 1471-2865 (Electronic) IS - 1358-2267 (Print) IS - 1358-2267 (Linking) VI - 31 IP - 4 DP - 2026 Oct TI - Greek Translation and Preliminary Test-Retest Reliability of the AQUA CHILD Questionnaire in Children With Developmental Disabilities. PG - e70357 LID - 10.1002/pri.70357 [doi] LID - e70357 AB - BACKGROUND AND PURPOSE: AQUA CHILD is a parent-proxy questionnaire for pre-aquatic assessment. This study describes its Greek translation and examines preliminary test-retest agreement, with explicit verification of response coding and the limits of score interpretation. METHODS: In a methodological repeated-measures study, 47 parents completed the questionnaire 7 days apart. The retained electronic paired files contained 99 of the 102 numbered items on the supplied forms. Swimming responses were analysed categorically; 20 non-swimming domain summaries were analysed as exploratory raw-code sums, excluding non-applicable responses and using complete domain pairs (n = 43-47). Intraclass correlation coefficients for absolute agreement, ICC(A, 1), and 95% confidence intervals (CIs), systematic differences, measurement-error estimates, and participant-level Bland-Altman analyses were calculated. No overall score was retained. RESULTS: Swimming-item exact agreement was 91.5%-97.9% (unweighted kappa, 0.899-0.974). Non-swimming ICCs ranged from 0.878 to 0.968, with lower 95% CI limits of 0.786-0.942. Only undertaking a single task retained a mean retest increase after Holm adjustment: 0.22 raw-code points (95% CI, 0.09-0.34; adjusted p = 0.019). Baseline domain alpha coefficients ranged from -0.375 to 0.329. At T2, 41 non-swimming responses from 24 of 47 participants were 'not relevant', all 'not capable' at T1; none were 'not relevant' at T1. Two domain analyses used incomplete item sets. Normal-theory limits of agreement were sensitive to the discrete, zero-heavy differences. DISCUSSION: These estimates describe the retained electronic records. The original paper questionnaires are no longer available, so the accuracy and origin of the 41 transitions could not be independently verified; this unresolved data-quality issue may bias reliability estimates. Unconfirmed clinical stability, incomplete adaptation records, and missing items further limit inference. The findings do not establish validated domain scales, diagnosis-specific reliability, or an overall score. Prospective validation with independent source-data verification remains necessary before individual treatment decisions. CI - (c) 2026 The Author(s). Physiotherapy Research International published by John Wiley & Sons Ltd. FAU - Triantafyllidou, Stavroula AU - Triantafyllidou S AD - Department of Physiotherapy, School of Health Sciences, University of Thessaly, Lamia, Greece. FAU - Tsangala, Michaela Christina AU - Tsangala MC AD - Department of Physiotherapy, School of Health Sciences, University of Thessaly, Lamia, Greece. FAU - Tsounia, Eleni Argyroula AU - Tsounia EA AD - Department of Physiotherapy, School of Health Sciences, University of Thessaly, Lamia, Greece. FAU - Moscholouri, Chrysoula AU - Moscholouri C AUID- ORCID: 0000-0002-9706-3328 AD - Department of Physiotherapy, School of Health Sciences, University of Thessaly, Lamia, Greece. FAU - Besios, Thomas AU - Besios T AUID- ORCID: 0000-0002-0373-8188 AD - Department of Physiotherapy, School of Health Sciences, University of Thessaly, Lamia, Greece. FAU - Paras, George AU - Paras G AUID- ORCID: 0000-0003-4106-0803 AD - Department of Physiotherapy, School of Health Sciences, University of Thessaly, Lamia, Greece. FAU - Morales, Alfonso Trinidad AU - Morales AT AUID- ORCID: 0000-0002-3767-3642 AD - Department of Education and Educational Innovation, Faculty of Law, Education and Humanities, Universidad Europea de Madrid, Villaviciosa de Odon, Madrid, Spain. AD - Aqualab Research Group, Universidad Europea de Madrid, Villaviciosa de Odon, Madrid, Spain. FAU - Chandolias, Konstantinos AU - Chandolias K AUID- ORCID: 0000-0001-6050-4559 AD - Department of Physiotherapy, School of Health Sciences, University of Thessaly, Lamia, Greece. AD - Department of Physiotherapy, Health Assessment and Quality of Life Research Laboratory, School of Health Sciences, University of Thessaly, Lamia, Greece. LA - eng PT - Journal Article PL - United States TA - Physiother Res Int JT - Physiotherapy research international : the journal for researchers and clinicians in physical therapy JID - 9612022 SB - IM MH - Humans MH - Reproducibility of Results MH - Surveys and Questionnaires MH - Male MH - Female MH - *Developmental Disabilities/diagnosis/rehabilitation MH - Child MH - Greece MH - Child, Preschool MH - *Swimming/physiology MH - *Disability Evaluation MH - Translations PMC - PMC13648008 OTO - NOTNLM OT - child OT - cross-cultural adaptation OT - disability OT - psychometrics OT - questionnaires COIS- The authors declare no conflicts of interest. EDAT- 2026/10/08 17:35 MHDA- 2026/10/08 17:36 PMCR- 2026/10/08 CRDT- 2026/10/08 15:17 PHST- 2026/09/08 00:00 [revised] PHST- 2026/07/24 00:00 [received] PHST- 2026/09/25 00:00 [accepted] PHST- 2026/10/08 17:36 [medline] PHST- 2026/10/08 17:35 [pubmed] PHST- 2026/10/08 15:17 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - PRI70357 [pii] AID - 10.1002/pri.70357 [doi] PST - ppublish SO - Physiother Res Int. 2026 Oct;31(4):e70357. doi: 10.1002/pri.70357. PMID- 42846299 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261008 LR - 20261010 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - An interpretable machine-learning model identifies obesity-related metabolic complications in children attending a tertiary obesity clinic. PG - 1969179 LID - 10.3389/fped.2026.1969179 [doi] LID - 1969179 AB - Childhood obesity-related metabolic complications are common in Northwest China, yet region-specific evidence and risk-stratification tools are lacking. In a single-visit cross-sectional study of 131 children (3-18 years) with overweight or obesity attending a Gansu maternal and child-care hospital, obesity-related metabolic complications (ORMC) were present in 31.3% (dyslipidaemia 16.0%, hyperuricaemia 9.2%, elevated blood pressure 7.6%). An interpretable model combining LASSO-selected adiposity measures (body mass index, neck circumference, body fat percentage) with penalised logistic regression achieved moderate, internally cross-validated discrimination (AUC 0.72, 95% CI 0.62-0.82) that awaits external validation, comparable to a random forest (0.73). Screen time was the strongest modifiable behavioural correlate. Routine metabolic screening and simple body-composition measures should be embedded in paediatric obesity clinics, with screen-time reduction as a counselling priority. CI - (c) 2026 Li, Nan, Wei, Zhu, Li, Zhang, Wang, Da, Chai, Wang and Xie. FAU - Li, Tingting AU - Li T AD - Department of Child Health Care, Gansu Province Maternity and Child Health Hospital, Lanzhou, Gansu, China. FAU - Nan, Nan AU - Nan N AD - Department of Child Health Care, Gansu Province Maternity and Child Health Hospital, Lanzhou, Gansu, China. FAU - Wei, Wenjie AU - Wei W AD - Department of Child Health Care, Gansu Province Maternity and Child Health Hospital, Lanzhou, Gansu, China. FAU - Zhu, Ying AU - Zhu Y AD - Department of Child Health Care, Gansu Province Maternity and Child Health Hospital, Lanzhou, Gansu, China. FAU - Li, Jiayue AU - Li J AD - Department of Child Health Care, Gansu Province Maternity and Child Health Hospital, Lanzhou, Gansu, China. FAU - Zhang, Lingzhi AU - Zhang L AD - Department of Child Health Care, Gansu Province Maternity and Child Health Hospital, Lanzhou, Gansu, China. FAU - Wang, Bingwu AU - Wang B AD - Department of Child Health Care, Gansu Province Maternity and Child Health Hospital, Lanzhou, Gansu, China. FAU - Da, Zhenqiang AU - Da Z AD - Department of Child Health Care, Gansu Province Maternity and Child Health Hospital, Lanzhou, Gansu, China. FAU - Chai, Jiaxin AU - Chai J AD - School of Cyberspace Security, Gansu University of Political Science and Law, Lanzhou, Gansu, China. FAU - Wang, Cheng AU - Wang C AD - Department of Child Health Care, Gansu Province Maternity and Child Health Hospital, Lanzhou, Gansu, China. FAU - Xie, Xingwen AU - Xie X AD - Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, Gansu, China. LA - eng PT - Journal Article DEP - 20260923 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13642582 OTO - NOTNLM OT - LASSO OT - body composition OT - childhood obesity OT - machine learning OT - metabolic complications OT - risk prediction COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/08 17:35 MHDA- 2026/10/08 17:36 PMCR- 2026/09/23 CRDT- 2026/10/08 11:46 PHST- 2026/08/16 00:00 [received] PHST- 2026/09/02 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/08 17:36 [medline] PHST- 2026/10/08 17:35 [pubmed] PHST- 2026/10/08 11:46 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - 10.3389/fped.2026.1969179 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 23;14:1969179. doi: 10.3389/fped.2026.1969179. eCollection 2026. PMID- 42845756 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261009 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Digital health literacy moderates the school sports environment and physical activity pathway among Chinese adolescents: a health equity perspective. PG - 1967478 LID - 10.3389/fpubh.2026.1967478 [doi] LID - 1967478 AB - BACKGROUND: Physical inactivity among Chinese adolescents remains a pressing public health concern, with pronounced urban-rural disparities. School sports environments serve as a critical determinant of adolescent physical activity (PA), yet the conditions under which this relationship strengthens or weakens remain insufficiently understood. Digital health literacy (DHL) has emerged as a potential moderator that may amplify or buffer environmental influences on PA behavior. METHODS: A cross-sectional survey was conducted among 2,531 adolescents (M(age) = 15.2 +/- 1.8 years; 51.3% male) recruited through stratified cluster sampling from 18 secondary schools in Hubei Province, China (9 urban, 9 rural). Participants completed validated Chinese versions of the Questionnaire Assessing School Physical Activity Environment (Q-SPACE-Chi), the eHealth Literacy Scale (eHEALS), and the International Physical Activity Questionnaire-Short Form (IPAQ-SF). Structural equation modeling with a latent interaction term tested the moderating role of DHL, and multigroup analysis examined urban-rural differences. Reporting followed the STROBE guideline. RESULTS: School sports environment was positively associated with PA levels (beta = 0.34, p < 0.001). DHL significantly moderated this pathway (interaction beta = 0.12, p = 0.003), such that the environment-PA association was stronger among adolescents with higher DHL. Multigroup analysis revealed a significantly stronger environmental effect in urban (beta = 0.38) than in rural schools (beta = 0.29; z = 2.87, p = 0.004); the DHL moderation was significant in urban (beta = 0.14, p = 0.008) but not rural schools (beta = 0.07, p = 0.14), and the between-group difference in the moderation effect was not significant (z = 0.99, p = 0.32). The model demonstrated acceptable fit (chi (2)/df = 3.12, CFI = 0.94, TLI = 0.93, RMSEA = 0.045, SRMR = 0.041). CONCLUSION: DHL amplifies the translation of favorable school sports environments into actual PA engagement, and the environment-PA association was stronger in urban schools. These findings suggest a potential pathway through which digital inequities may contribute to PA disparities, a possibility that requires longitudinal confirmation, and underscore the need for integrated school-based and digital literacy interventions to advance health equity. CI - Copyright (c) 2026 Zhang. FAU - Zhang, Bing AU - Zhang B AD - School of Physical Education, Huanggang Normal University, Huanggang, Hubei, China. LA - eng PT - Journal Article DEP - 20260923 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Adolescent MH - Male MH - China MH - Cross-Sectional Studies MH - *Health Literacy/statistics & numerical data MH - Female MH - *Schools MH - *Exercise MH - *Sports MH - Digital Health MH - Surveys and Questionnaires MH - *Health Equity MH - Rural Population/statistics & numerical data MH - Urban Population/statistics & numerical data PMC - PMC13642271 OTO - NOTNLM OT - adolescents OT - digital health literacy OT - health equity OT - physical activity OT - school sports environment OT - social ecological model OT - urban-rural disparity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/08 11:39 MHDA- 2026/10/08 11:40 PMCR- 2026/09/23 CRDT- 2026/10/08 08:26 PHST- 2026/08/14 00:00 [received] PHST- 2026/09/05 00:00 [revised] PHST- 2026/09/08 00:00 [accepted] PHST- 2026/10/08 11:40 [medline] PHST- 2026/10/08 11:39 [pubmed] PHST- 2026/10/08 08:26 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1967478 [doi] PST - epublish SO - Front Public Health. 2026 Sep 23;14:1967478. doi: 10.3389/fpubh.2026.1967478. eCollection 2026. PMID- 42845016 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261008 IS - 1532-2998 (Electronic) IS - 1532-3005 (Linking) VI - 42 IP - 5 DP - 2026 Oct TI - Decoding the Anxiety Burden in Asia and Developing an XGBoost-Based Online Screening Tool Using Korean Data. PG - e70231 LID - 10.1002/smi.70231 [doi] AB - Anxiety disorders impose a substantial burden across Asia, yet comprehensive regional surveillance remains limited. In addition, the utility of the Health-Related Quality of Life Instrument with 8 Items (HINT-8) for anxiety screening in the Korean population has not been fully clarified. This study integrated data from Global Burden of Disease (GBD) 2021 and Korea National Health and Nutrition Examination Survey (KNHANES) to comprehensively assess the prevalence, incidence, and disability-adjusted life year (DALY) rates of Anxiety disorders across 48 Asian countries and territories from 1990 to 2021. Joinpoint regression, age-period-cohort modelling, decomposition analysis, and health inequality indices were employed to analyse trends and driving factors. In the Korean dataset, eight machine learning algorithms were compared. SHAP analysis was used to interpret the results, and the best-performing model was ultimately developed into an online prediction model. In 2021, Asia accounted for over half of global anxiety cases, and age-standardized rates increased by 14.6%-17.1% since 1990. After 2019, incidence (APC = 9.532%) and DALY rates (APC = 9.157%) rose sharply. Burden patterns varied by sex and age, and population growth was a major driver. In the Korean dataset, XGBoost showed the best performance (AUC = 0.894). An 8-feature parsimonious model performed comparably to the 17-feature model while improving interpretability and practical feasibility. Asia's growing anxiety burden demands prioritised care for women, adolescents, and middle-aged populations and better crisis mental health services. A Korean machine-learning tool shows potential but requires broader Asian validation. CI - (c) 2026 John Wiley & Sons Ltd. All rights reserved, including rights for text and data mining and training of artificial intelligence technologies or similar technologies. FAU - Cao, Runmin AU - Cao R AUID- ORCID: 0000-0002-8173-2961 AD - Clinical Medical College, Jinzhou Medical University, Jinzhou, Liaoning Province, China. FAU - Zhang, Yurun AU - Zhang Y AUID- ORCID: 0009-0008-7335-9272 AD - Rehabilitation Therapy, Shandong XIANDAI University, Jinan City, Shandong Province, China. FAU - Cao, Ling AU - Cao L AD - Jieshou City Center for Disease Control and Prevention, Fuyang City, Anhui Province, China. FAU - Jiang, Honghe AU - Jiang H AUID- ORCID: 0009-0007-3799-7202 AD - Department of Clinical Medicine, Anhui University of Science and Technology, Huainan City, Anhui Province, China. LA - eng PT - Journal Article PL - England TA - Stress Health JT - Stress and health : journal of the International Society for the Investigation of Stress JID - 101089166 SB - IM MH - Humans MH - Female MH - Republic of Korea/epidemiology MH - *Anxiety Disorders/epidemiology/diagnosis MH - Middle Aged MH - Adult MH - Male MH - Boosting Machine Learning Algorithms MH - Incidence MH - Prevalence MH - Asia/epidemiology MH - Nutrition Surveys MH - *Mass Screening/methods MH - Aged MH - Disability-Adjusted Life Years MH - Quality of Life OTO - NOTNLM OT - Asian burden of disease OT - Korean cohort OT - anxiety disorders OT - machine learning EDAT- 2026/10/08 05:31 MHDA- 2026/10/08 05:32 CRDT- 2026/10/08 03:14 PHST- 2026/07/13 00:00 [revised] PHST- 2026/01/30 00:00 [received] PHST- 2026/10/01 00:00 [accepted] PHST- 2026/10/08 05:32 [medline] PHST- 2026/10/08 05:31 [pubmed] PHST- 2026/10/08 03:14 [entrez] AID - 10.1002/smi.70231 [doi] PST - ppublish SO - Stress Health. 2026 Oct;42(5):e70231. doi: 10.1002/smi.70231. PMID- 42844973 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261016 IS - 1399-3038 (Electronic) IS - 0905-6157 (Print) IS - 0905-6157 (Linking) VI - 37 IP - 10 DP - 2026 Oct TI - Feeding characteristics in young children with IgE-mediated food allergies: A cross-sectional observational study. PG - e70508 LID - 10.1111/pai.70508 [doi] LID - e70508 AB - BACKGROUND: Research is limited regarding the intersection between Immunoglobulin-E (IgE)-mediated food allergies and paediatric feeding Disorder (PFD). The impact on caregivers managing a child with both conditions also remains poorly understood. OBJECTIVE: This study aimed to explore feeding characteristics in young children with IgE-mediated food allergies to identify the proportion of children who may be at risk of PFD, and to examine associations between risk of PFD and caregiver-reported stress and feeding-related quality of life. METHODS: A cross-sectional cohort (N = 107) of caregivers of children aged 0;6-4;11 years, with at least one diagnosed IgE-mediated food allergy, was recruited from three paediatric allergy clinics. Validated caregiver-reported questionnaires were used to assess feeding behaviours, caregiver stress and feeding-related quality of life. RESULTS: Seventeen (16%) children were identified as being at risk of PFD based on the Behavioural Pediatric Feeding Assessment Scale-Total Frequency Score (BPFAS-TFS). Across the cohort, caregiver stress fell within the expected range. However, caregivers of children at risk of PFD reported significantly higher levels of stress on the Parental Stress Scale (PSS) (p < .001) and poorer feeding-related quality of life on the Feeding Swallowing-Impact Scale (FS-IS) (p < .001). CONCLUSION: Sixteen percent of children with IgE-mediated food allergies screened as being at risk of PFD, suggesting that screening and assessment of PFD are valuable in this population. More frequent difficult mealtime behaviours were associated with increased caregiver stress and lower feeding-related quality of life. Health services must recognise the compounded stressors of managing both food allergies and feeding behaviours/PFD to deliver holistic, family-centred care. CI - (c) 2026 The Author(s). Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. FAU - Kefford, Jennifer AU - Kefford J AUID- ORCID: 0000-0002-0465-6029 AD - School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Queensland, Australia. AD - Northern Sydney Local Health District, New South Wales Health, Sydney, New South Wales, Australia. FAU - Ward, Elizabeth C AU - Ward EC AUID- ORCID: 0000-0002-2680-8978 AD - School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Queensland, Australia. AD - Centre for Functioning and Health Research (CFAHR), Metro South Hospital and Health Service, Brisbane, Queensland, Australia. FAU - Packer, Rebecca L AU - Packer RL AUID- ORCID: 0000-0002-5744-7757 AD - School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Queensland, Australia. FAU - Netting, Merryn AU - Netting M AUID- ORCID: 0000-0002-0642-9145 AD - National Allergy Council, Sydney, New South Wales, Australia. AD - Department of Paediatrics, University of Adelaide, Adelaide, South Australia, Australia. FAU - Swamy, Shruti AU - Swamy S AUID- ORCID: 0009-0008-2396-3260 AD - The University of Sydney, Sydney, New South Wales, Australia. AD - Royal Prince Alfred Hospital, Sydney, New South Wales, Australia. AD - Royal North Shore Hospital, Sydney, New South Wales, Australia. AD - Sydney Children's Hospital Randwick, Sydney, New South Wales, Australia. FAU - Ford, Lara S AU - Ford LS AD - The University of Sydney, Sydney, New South Wales, Australia. AD - The Children's Hospital at Westmead, Sydney, New South Wales, Australia. FAU - Marshall, Jeanne AU - Marshall J AUID- ORCID: 0000-0003-0652-9258 AD - School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Queensland, Australia. AD - Queensland Children's Hospital, Children's Health Queensland Hospital and Health Service, Brisbane, Queensland, Australia. LA - eng GR - Speech Pathology Australia/ PT - Journal Article PT - Observational Study PL - England TA - Pediatr Allergy Immunol JT - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JID - 9106718 RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Food Hypersensitivity/epidemiology/immunology MH - Female MH - Male MH - Child, Preschool MH - Infant MH - *Feeding Behavior MH - Immunoglobulin E/immunology/blood MH - Quality of Life MH - Caregivers/psychology MH - Stress, Psychological/epidemiology MH - Surveys and Questionnaires MH - Child MH - *Feeding and Eating Disorders of Childhood/epidemiology PMC - PMC13646849 OTO - NOTNLM OT - caregiver burden OT - feeding and eating disorders OT - feeding behaviours OT - food allergy OT - food hypersensitivity COIS- None. EDAT- 2026/10/08 05:31 MHDA- 2026/10/08 05:32 PMCR- 2026/10/08 CRDT- 2026/10/08 02:54 PHST- 2026/09/15 00:00 [revised] PHST- 2026/03/07 00:00 [received] PHST- 2026/09/23 00:00 [accepted] PHST- 2026/10/08 05:32 [medline] PHST- 2026/10/08 05:31 [pubmed] PHST- 2026/10/08 02:54 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - PAI70508 [pii] AID - 10.1111/pai.70508 [doi] PST - ppublish SO - Pediatr Allergy Immunol. 2026 Oct;37(10):e70508. doi: 10.1111/pai.70508. PMID- 42843149 OWN - NLM STAT- Publisher LR - 20261022 IS - 1878-9307 (Electronic) IS - 1878-9293 (Print) IS - 1878-9293 (Linking) VI - 82 DP - 2026 Sep 21 TI - A systematic review of digital and wearable sensor data in the ABCD study: Insights, methods, and emerging opportunities. PG - 101826 LID - S1878-9293(26)00168-4 [pii] LID - 10.1016/j.dcn.2026.101826 [doi] LID - 101826 AB - Research into key adolescent health domains, like problematic screen-based media use, sleep health, and physical activity, are frequently limited by error-prone self-report-based measures. To improve the measurement of such behaviors, the Adolescent Brain Cognitive Development Study (ABCD), a diverse longitudinal cohort study of nearly 12,000 U.S. youth (ages 9-10 at Baseline), includes remote sensing protocols during data collection. Consenting participants provided up to three weeks of Fitbit actigraphy data, beginning at the year-two follow up, and smartphone usage data, beginning at the year-four follow up, collected via the Effortless Assessment of Research Systems (EARS) smartphone application. This systematic review aimed to identify and synthesize all published empirical studies which have utilized the ABCD Study's passive sensor data, identifying 45 articles investigating measurement validity, and associations with adolescent health, development, and neurocognitive functioning. Fitbit devices broadly reproduced estimates of sleep and physical activity obtained from research-grade sensors. Smartphone sensor data were internally consistent, reproduced expected daily usage patterns, and were moderately correlated with self-report. Most substantive studies utilized Fitbit data and reported cross-sectional associations between sensor-derived single-item summary statistics and survey-based measures of mental and behavioral health, neurocognitive functioning, or environmental risk factors. A smaller number of studies utilized longitudinal designs, within-person analyses, machine learning approaches, and/or genetic or neuroimaging methods to reduce confounding and enhance biological and etiological insight into these observed relationships. While published findings were largely incremental in nature, ABCD's passive sensing resources nonetheless represent a powerful, widely available resource for incorporating sensor-based measures into adolescent health research. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Alexander, Jordan D AU - Alexander JD AD - Psychology Department, University of Maine, Orono, ME, United States. Electronic address: jordan.d.alexander@maine.edu. FAU - Mills, Sawyer AU - Mills S AD - Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA, United States. FAU - Sumpter, Kelsey AU - Sumpter K AD - School of Medicine, University of Maryland at Baltimore, Baltimore, MD, United States. FAU - Smith, Calen J AU - Smith CJ AD - J. Craig Venter Institute, La Jolla, CA, United States. FAU - Das, Biplabendu AU - Das B AD - J. Craig Venter Institute, La Jolla, CA, United States. FAU - Fan, Ruby AU - Fan R AD - Center for Health Sciences, SRI International, Menlo Park, CA, United States. FAU - Hunt, Ethan T AU - Hunt ET AD - University of Texas Health Science Center at Houston (UTHealth) School of Public Health - Austin Campus, Austin, TX, United States. FAU - Brown, Sandra A AU - Brown SA AD - Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States. FAU - Curtis, Brenda L AU - Curtis BL AD - National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, United States. FAU - Cummins, Kevin M AU - Cummins KM AD - Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States. FAU - Mason, Michael AU - Mason M AD - Center for Behavioral Health Research, University of Tennessee Knoxville, Knoxville, TN, United States. FAU - Neale, Michael C AU - Neale MC AD - Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, United States. FAU - Tapert, Susan F AU - Tapert SF AD - Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States. FAU - Baker, Fiona C AU - Baker FC AD - Center for Health Sciences, SRI International, Menlo Park, CA, United States. FAU - Fuemmeler, Bernard F AU - Fuemmeler BF AD - Department of Family Medicine and Population Health, Virginia Commonwealth University, Richmond, VA, United States. FAU - Wade, Natasha E AU - Wade NE AD - Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States. LA - eng GR - U24 DA041147/DA/NIDA NIH HHS/United States GR - U01 DA051039/DA/NIDA NIH HHS/United States GR - U01 DA041120/DA/NIDA NIH HHS/United States GR - K08 DA050779/DA/NIDA NIH HHS/United States GR - U01 DA051018/DA/NIDA NIH HHS/United States GR - U01 DA041093/DA/NIDA NIH HHS/United States GR - U24 DA041123/DA/NIDA NIH HHS/United States GR - U01 DA051038/DA/NIDA NIH HHS/United States GR - U01 DA051037/DA/NIDA NIH HHS/United States GR - U01 DA051016/DA/NIDA NIH HHS/United States GR - U01 DA041106/DA/NIDA NIH HHS/United States GR - U01 DA041117/DA/NIDA NIH HHS/United States GR - T32 DA050560/DA/NIDA NIH HHS/United States GR - U01 DA041174/DA/NIDA NIH HHS/United States GR - U01 DA041134/DA/NIDA NIH HHS/United States GR - U01 DA041022/DA/NIDA NIH HHS/United States GR - U01 DA041156/DA/NIDA NIH HHS/United States GR - U01 DA050987/DA/NIDA NIH HHS/United States GR - U01 DA041025/DA/NIDA NIH HHS/United States GR - U01 DA050989/DA/NIDA NIH HHS/United States GR - U01 DA041089/DA/NIDA NIH HHS/United States GR - U01 DA050988/DA/NIDA NIH HHS/United States GR - U01 DA041028/DA/NIDA NIH HHS/United States GR - U01 DA041048/DA/NIDA NIH HHS/United States GR - ZIA DA000628/ImNIH/Intramural NIH HHS/United States GR - U01 DA041148/DA/NIDA NIH HHS/United States PT - Journal Article DEP - 20260921 PL - Netherlands TA - Dev Cogn Neurosci JT - Developmental cognitive neuroscience JID - 101541838 SB - IM PMC - PMC13676921 OTO - NOTNLM OT - Adolescent development OT - Fitbit OT - Passive Sensing OT - Physical Activity OT - Sensor based data OT - Sleep OT - Smartphone Use COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/07 23:30 MHDA- 2026/10/07 23:30 PMCR- 2026/09/21 CRDT- 2026/10/07 18:09 PHST- 2025/12/01 00:00 [received] PHST- 2026/09/16 00:00 [revised] PHST- 2026/09/17 00:00 [accepted] PHST- 2026/10/07 23:30 [medline] PHST- 2026/10/07 23:30 [pubmed] PHST- 2026/10/07 18:09 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - S1878-9293(26)00168-4 [pii] AID - 101826 [pii] AID - 10.1016/j.dcn.2026.101826 [doi] PST - aheadofprint SO - Dev Cogn Neurosci. 2026 Sep 21;82:101826. doi: 10.1016/j.dcn.2026.101826. PMID- 42840151 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261007 LR - 20261008 IS - 2251-6581 (Print) IS - 2251-6581 (Electronic) IS - 2251-6581 (Linking) VI - 25 IP - 2 DP - 2026 Dec TI - Empirical dietary and lifestyle indices for hyperinsulinemia and insulin resistance in relation to metabolic health in overweight and obese children and adolescents. PG - 282 LID - 10.1007/s40200-026-02096-y [doi] LID - 282 AB - PURPOSE: Empirical dietary and lifestyle indices reflecting hyperinsulinemia and insulin resistance have been associated with adverse metabolic outcomes in adults, but pediatric evidence is limited. We examined associations with metabolic health phenotypes in youth with excess weight. METHODS: In this cross-sectional study, 427 Iranian participants aged 6-18 years with overweight or obesity were classified as metabolically healthy obese (MHO) or metabolically unhealthy obese (MUO) using established cardiometabolic criteria. Dietary intake was assessed with a validated food frequency questionnaire. Modified versions of the empirical dietary and lifestyle indices for hyperinsulinemia (EDIH and ELIH) and insulin resistance (EDIR and ELIR) were calculated using the components available in the Iranian FFQ. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), with subgroup analyses by age and sex. RESULTS: Higher adherence to ELIH and ELIR was significantly associated with increased odds of MUO (OR for Q4 vs. Q1: 3.19 and 2.41, respectively; P-trend < 0.05), while no significant associations were observed for EDIH or EDIR. Exploratory subgroup analyses showed ELIH-MUO associations in participants aged < 10 years and boys, EDIR-MUO associations in girls, and ELIR-MUO associations in girls and, for the Q4-versus-Q1 comparison only, participants aged >/= 10 years (P-trend = 0.09). CONCLUSIONS: Higher lifestyle-based insulinemic scores, particularly ELIH and ELIR, were associated with an unfavorable metabolic phenotype in youth with excess weight. Because these modified indices are empirical biomarker-prediction tools, their component weights should not be interpreted as causal effects of individual foods. Prospective and population-specific validation studies are warranted. TRIAL REGISTRATION: Not applicable. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at https://doi.org/10.1007/s40200-026-02096-y. CI - (c) The Author(s), under exclusive licence to Tehran University of Medical Sciences 2026. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. FAU - Nikparast, Ali AU - Nikparast A AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/034m2b326. GRID: grid.411600.2 FAU - Nourian, Nazanin Zahra AU - Nourian NZ AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/034m2b326. GRID: grid.411600.2 FAU - Tabatabaeyan, Ali AU - Tabatabaeyan A AD - Department of Clinical Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Students' Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran. ROR: https://ror.org/04waqzz56. GRID: grid.411036.1. ISNI: 0000 0001 1498 685X FAU - Razavi, Maryam AU - Razavi M AD - Growth and Development Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/01c4pz451. GRID: grid.411705.6. ISNI: 0000 0001 0166 0922 FAU - Khoshnezhad Afkham, Ehsan AU - Khoshnezhad Afkham E AD - Department of Pediatrics, School of Medicine, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/01c4pz451. GRID: grid.411705.6. ISNI: 0000 0001 0166 0922 FAU - Etesami, Elahe AU - Etesami E AD - Department of Nutrition, SR.C., Islamic Azad University, Tehran, Iran. ROR: https://ror.org/01kzn7k21. GRID: grid.411463.5. ISNI: 0000 0001 0706 2472 FAU - Asghari, Golaleh AU - Asghari G AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/034m2b326. GRID: grid.411600.2 LA - eng PT - Journal Article DEP - 20261005 PL - Switzerland TA - J Diabetes Metab Disord JT - Journal of diabetes and metabolic disorders JID - 101590741 PMC - PMC13638921 OTO - NOTNLM OT - Empirical dietary index OT - Hyperinsulinemia OT - Insulin resistance OT - Metabolic health OT - Pediatric obesity COIS- Competing interestsThe authors declare no competing interests. EDAT- 2026/10/07 11:32 MHDA- 2026/10/07 11:33 PMCR- 2027/10/05 CRDT- 2026/10/07 07:05 PHST- 2025/10/18 00:00 [received] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/07 11:33 [medline] PHST- 2026/10/07 11:32 [pubmed] PHST- 2026/10/07 07:05 [entrez] PHST- 2027/10/05 00:00 [pmc-release] AID - 2096 [pii] AID - 10.1007/s40200-026-02096-y [doi] PST - epublish SO - J Diabetes Metab Disord. 2026 Oct 5;25(2):282. doi: 10.1007/s40200-026-02096-y. eCollection 2026 Dec. PMID- 42837523 OWN - NLM STAT- MEDLINE DCOM- 20261006 LR - 20261008 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Oct 6 TI - Remote Longitudinal Tracking of Sleep, Depression, and Cognition Across Early Adolescence: Protocol for a Longitudinal Observational Study. PG - e86345 LID - 10.2196/86345 [doi] LID - e86345 AB - BACKGROUND: Depression in adolescents is a growing public health concern, with 3.5 million youth in the United States experiencing a depressive episode each year. When symptoms emerge in early adolescence, they can have lasting psychological, physical, and cognitive consequences, highlighting the urgent need for proactive intervention. Insufficient sleep-characterized by short duration, irregular timing, and poor quality-is bidirectionally linked to depression and associated with impaired cognitive performance. OBJECTIVE: This protocol provides the map for a study tracking sleep patterns and neurophysiology, as well as a range of depressive symptoms, and their dynamic interaction in shaping longitudinal cognitive trajectories. METHODS: Fifty-six youth aged 9 to 13 (mean 11.01, SD 1.39) years were enrolled in a longitudinal measurement burst design comprising 4 assessment waves at baseline, 4, 8, and 12 months. We recruited a sample of youth with a range of depressive symptom severity. Each wave included 7 consecutive days of monitoring during which participants used a personalized mobile health (mHealth) platform, HowRU app, developed by the study team, to report daily sleep patterns, thrice-daily ecological momentary assessments (EMAs), and completed a series of cognitive tasks. Youth and parents also completed validated psychosocial questionnaires to assess mood, behavioral concerns, mental health, and sleep. Sleep and physical activity were monitored remotely using a Garmin VivoSmart 5 watch and Interaxon Muse S headbands. Sleep-dependent cognitive performance was assessed with 2 declarative memory tasks (Word-Pair Associates task [WPA] and Minecraft Memory and Navigation [MMN] task), a procedural memory task (Motor Sequence task), and 2 executive functioning tasks (Operation Span [OSpan] task and Rule Switch task [RST]). For the memory tasks, participants completed training and immediate testing in the evening, followed by a retention test the following morning. The OSpan task and Rule Switch were administered twice daily (morning and evening). For all tasks, stimuli were randomized and counterbalanced across participants and testing sessions. RESULTS: Funding was obtained from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (grant K08 HD107161), with a budget period of August 1, 2022, to July 31, 2027. Participant enrollment occurred May 2023 through October 2024. Data collection began in July 2023 and was completed in October 2025. Study participant retention and adherence rates for sleep diaries, cognitive tasks, and questionnaires were high. Primary outcomes of the study are anticipated to be published in fall 2026. CONCLUSIONS: This protocol provides a robust and reproducible framework to longitudinally track youth with a range of depressive symptoms in the real world using mHealth platforms and wearable technology. Potential findings can support the identification of key developmental periods of vulnerability and resilience in youth, inform future sleep-based interventions to promote mental health, and optimize cognitive outcomes across early adolescence. CI - (c) Katharine C Simon, Lia Galut, Spencer Polk, Shun Iwata, Weining Shen, Mahyar Abbasian, Amir Rahmani, Uma Rao, Jessica L Borelli, Sara C Mednick. Originally published in JMIR Research Protocols (https://www.researchprotocols.org). FAU - Simon, Katharine C AU - Simon KC AUID- ORCID: 0000-0001-8149-4636 AD - Department of Pediatrics, University of California, Irvine, School of Medicine, 5141 California Ave, Irvine, CA, 92697, United States, 1 8054534462. AD - Pulmonology Department, Rady Children's Health, Children's Hospital of Orange County, Orange, CA, United States. FAU - Galut, Lia AU - Galut L AUID- ORCID: 0009-0003-0936-4441 AD - Department of Pediatrics, University of California, Irvine, School of Medicine, 5141 California Ave, Irvine, CA, 92697, United States, 1 8054534462. AD - Pulmonology Department, Rady Children's Health, Children's Hospital of Orange County, Orange, CA, United States. FAU - Polk, Spencer AU - Polk S AUID- ORCID: 0009-0008-1878-2078 AD - Pulmonology Department, Rady Children's Health, Children's Hospital of Orange County, Orange, CA, United States. FAU - Iwata, Shun AU - Iwata S AUID- ORCID: 0009-0002-2578-8247 AD - Department of Pediatrics, University of California, Irvine, School of Medicine, 5141 California Ave, Irvine, CA, 92697, United States, 1 8054534462. FAU - Shen, Weining AU - Shen W AUID- ORCID: 0000-0003-3137-1085 AD - Department of Statistics, University of California, Irvine, Irvine, CA, United States. FAU - Abbasian, Mahyar AU - Abbasian M AUID- ORCID: 0009-0000-8448-3158 AD - Department of Computer Science, University of California, Irvine, Irvine, CA, United States. FAU - Rahmani, Amir AU - Rahmani A AUID- ORCID: 0000-0003-0725-1155 AD - School of Nursing, University of California, Irvine, Irvine, CA, United States. FAU - Rao, Uma AU - Rao U AUID- ORCID: 0000-0003-2191-279X AD - Department of Pediatrics, University of California, Irvine, School of Medicine, 5141 California Ave, Irvine, CA, 92697, United States, 1 8054534462. AD - Pulmonology Department, Rady Children's Health, Children's Hospital of Orange County, Orange, CA, United States. AD - Deparment of Psychiatry and Human Behavior, University of California, Irvine, School of Medicine, Irvine, CA, United States. AD - Department of Psychology, University of California, Irvine, Irvine, CA, United States. FAU - Borelli, Jessica L AU - Borelli JL AUID- ORCID: 0000-0001-8471-6732 AD - Department of Psychology, University of California, Irvine, Irvine, CA, United States. FAU - Mednick, Sara C AU - Mednick SC AUID- ORCID: 0000-0002-0906-3097 AD - Department of Cognitive Science, University of California, Irvine, Irvine, CA, United States. LA - eng GR - K08 HD107161/HD/NICHD NIH HHS/United States PT - Clinical Trial Protocol PT - Journal Article DEP - 20261006 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Cognition/physiology MH - *Depression/psychology/epidemiology MH - Ecological Momentary Assessment MH - Longitudinal Studies MH - *Sleep/physiology MH - Observational Studies as Topic PMC - PMC13641314 OTO - NOTNLM OT - cognition OT - depression OT - development OT - mobile health OT - remote research OT - sleep OT - wearable technology COIS- Conflicts of Interest: None declared. EDAT- 2026/10/06 17:31 MHDA- 2026/10/06 17:32 PMCR- 2026/10/06 CRDT- 2026/10/06 15:04 PHST- 2025/10/22 00:00 [received] PHST- 2026/08/04 00:00 [revised] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/10/06 17:32 [medline] PHST- 2026/10/06 17:31 [pubmed] PHST- 2026/10/06 15:04 [entrez] PHST- 2026/10/06 00:00 [pmc-release] AID - v15i1e86345 [pii] AID - 86345 [pii] AID - 10.2196/86345 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Oct 6;15:e86345. doi: 10.2196/86345. PMID- 42837391 OWN - NLM STAT- MEDLINE DCOM- 20261006 LR - 20261008 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 10 DP - 2026 TI - Gameful experience, exercise identity, and exercise adherence among Chinese university students: A moderated chain mediation model. PG - e0353100 LID - 10.1371/journal.pone.0353100 [doi] LID - e0353100 AB - BACKGROUND: Gamified fitness applications have grown in popularity, yet it remains unclear how gameful experience, defined as users' subjective perception of game-like engagement during app-supported exercise, is associated with exercise adherence. METHODS: A cross-sectional survey was conducted among N = 300 Chinese university students who were active users of gamified fitness applications. Data were collected via an online questionnaire platform (Questionnaire Star) from March 5 to April 5, 2026. Participants completed validated measures of gameful experience (GAMEX), exercise identity (EI), exercise habit formation (EHF), intolerance of uncertainty (IU), and exercise adherence (EA). A moderated chain mediation model was tested using hierarchical regression analysis and bias-corrected bootstrap resampling (5,000 iterations). An indirect effect was considered statistically different from zero when its 95% confidence interval excluded zero. RESULTS: Gameful experience was positively associated with exercise adherence ([Formula: see text] = .264, p < .001). The observed associations were consistent with three indirect pathways: GAMEX [Formula: see text] EI [Formula: see text] EA (effect = .065, 95% CI [.020, .114]); GAMEX [Formula: see text] EHF [Formula: see text] EA (effect = .043, 95% CI [.002, .087]); and GAMEX [Formula: see text] EI [Formula: see text] EHF [Formula: see text] EA (effect = .085, 95% CI [.054, .123]). IU moderated the GAMEX-EI association ([Formula: see text] = .237, p < .001, [Formula: see text] = .036); the estimated chain indirect effect ranged from .034 (95% CI [.001, .072]) at low IU to .136 (95% CI [.080, .201]) at high IU. These estimates describe conditional associations and do not establish causal or temporal ordering. CONCLUSIONS: The findings are consistent with the hypothesized ordering of gameful experience, exercise identity, exercise habit formation, and adherence, while alternative causal orderings remain possible. The moderation result suggests that IU may be a useful boundary condition to examine in longitudinal and experimental studies of identity-supportive app features. CI - Copyright: (c) 2026 Song et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Song, Jingjing AU - Song J AUID- ORCID: 0009-0007-3088-8900 AD - College of Physical Education and Health Management, Chongqing University of Education, Chongqing, China. FAU - Li, Jiaying AU - Li J AD - School of Physical Education, Chongqing University of Posts and Telecommunications, Chongqing, China. FAU - Li, Dan AU - Li D AD - School of Physical Education, Wuhan University of Science and Technology, Wuhan, Hubei, China. LA - eng PT - Journal Article DEP - 20261006 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - *Exercise/psychology MH - *Students/psychology MH - Male MH - Universities MH - Young Adult MH - Cross-Sectional Studies MH - China MH - Surveys and Questionnaires MH - *Video Games/psychology MH - Adult MH - Adolescent PMC - PMC13641342 COIS- The authors have declared that no competing interests exist. EDAT- 2026/10/06 17:31 MHDA- 2026/10/06 17:32 PMCR- 2026/10/06 CRDT- 2026/10/06 13:45 PHST- 2026/06/18 00:00 [received] PHST- 2026/09/14 00:00 [accepted] PHST- 2026/10/06 17:32 [medline] PHST- 2026/10/06 17:31 [pubmed] PHST- 2026/10/06 13:45 [entrez] PHST- 2026/10/06 00:00 [pmc-release] AID - PONE-D-26-28180 [pii] AID - 10.1371/journal.pone.0353100 [doi] PST - epublish SO - PLoS One. 2026 Oct 6;21(10):e0353100. doi: 10.1371/journal.pone.0353100. eCollection 2026. PMID- 42837008 OWN - NLM STAT- MEDLINE DCOM- 20261006 LR - 20261010 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 11 DP - 2026 Oct 6 TI - Evaluation of subclinical organ involvement with ultrasound elastography in childhood familial Mediterranean fever: relationships with disease activity, inflammatory markers, colchicine response, and genotype. LID - 806 [pii] LID - 10.1007/s00431-026-07408-1 [doi] AB - This study evaluates multiorgan shear-wave elastography (SWE) in children with familial Mediterranean fever (FMF) during attack-free periods and examines associations with clinical and inflammatory parameters. In this single-center, retrospective cross-sectional case-control study, SWE measurements of the liver, spleen, bilateral kidneys, pancreas, four mesenteric fat regions, and bilateral thyroid lobes were evaluated in 75 children with FMF and 52 matched healthy controls. Adjusted linear regression, generalized estimating equation (GEE), and Benjamini-Hochberg correction were applied. The cohort included 127 children; age, sex, weight, height, and BMI were comparable between groups. After adjustment for age, sex, and BMI, FMF patients showed higher SWE values at all 11 sites: liver (beta = 3.25 kPa; 95% CI, 2.55-3.95), right kidney (beta = 0.94 kPa; 95% CI, 0.31-1.57), left kidney (beta = 1.15 kPa; 95% CI, 0.57-1.74), spleen (beta = 1.24 kPa; 95% CI, 0.55-1.93), pancreas (beta = 0.88 kPa; 95% CI, 0.21-1.55), mesenteric fat regions (beta range, 1.43-2.06 kPa), right thyroid lobe (beta = 1.62 kPa; 95% CI, 0.73-2.51), and left thyroid lobe (beta = 2.94 kPa; 95% CI, 2.05-3.83). Repeated-measures GEE showed an overall adjusted FMF-control difference of 1.71 kPa and a significant group x organ-site interaction. Exploratory analyses showed no FDR-significant associations with disease duration, diagnostic delay, ISSF score, attack-free CRP/ESR, colchicine responsiveness, or M694V/M694V genotype. CONCLUSION: Children with FMF had higher multiorgan and mesenteric fat SWE-derived stiffness during attack-free periods. Multiorgan SWE may help evaluate subclinical tissue-level changes in pediatric FMF, but the cross-sectional design, lack of histopathologic validation, and exploratory subgroup analyses preclude causal or therapeutic conclusions. WHAT IS KNOWN: * Familial Mediterranean fever may be associated with persistent subclinical inflammation during attack-free periods. * Shear-wave elastography can noninvasively quantify tissue stiffness. WHAT IS NEW: * Children with FMF showed higher liver, spleen, kidney, pancreas, thyroid, and mesenteric fat stiffness than controls. * These differences persisted after adjustment for age, sex, and BMI. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Uslu, Hande AU - Uslu H AD - Department of Radiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. hande.uslu@kocaeli.edu.tr. FAU - Tosun, Mesude AU - Tosun M AD - Department of Radiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. FAU - Sahin, Nihal AU - Sahin N AD - Department of Pediatric Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. FAU - Ozaslan, Nebahat Zeynep AU - Ozaslan NZ AD - Department of Pediatric Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. FAU - Oksel, Betul AU - Oksel B AD - Department of Pediatric Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. FAU - Aydin, Duygu AU - Aydin D AD - Department of Pediatric Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. FAU - Apaydin, Hulusi Ferhat AU - Apaydin HF AD - Department of Radiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. FAU - Altin, Ece Devrim AU - Altin ED AD - Department of Radiology, Sakarya Yenikent State Hospital, Sakarya, Turkey. FAU - Sonmez, Hafize Emine AU - Sonmez HE AD - Department of Pediatric Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. LA - eng PT - Journal Article DEP - 20261006 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - SML2Y3J35T (Colchicine) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Familial Mediterranean Fever/drug therapy/diagnostic imaging/genetics MH - Female MH - Male MH - Child MH - *Elasticity Imaging Techniques/methods MH - Cross-Sectional Studies MH - Retrospective Studies MH - Case-Control Studies MH - *Colchicine/therapeutic use MH - Adolescent MH - Genotype MH - Pancreas/diagnostic imaging MH - Child, Preschool MH - Biomarkers/blood MH - Liver/diagnostic imaging MH - Spleen/diagnostic imaging MH - Kidney/diagnostic imaging MH - Thyroid Gland/diagnostic imaging OTO - NOTNLM OT - Colchicine resistance OT - Familial Mediterranean fever OT - Multiorgan ultrasonography OT - Pediatric OT - Shear-wave elastography COIS- Declarations. Ethics approval: The study protocol was approved by the Local Research Ethics Committee (Approval No. 2026/137) and was conducted in accordance with the principles of the Declaration of Helsinki. Informed consent: The requirement for written informed consent was waived by the Local Research Ethics Committee. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/06 17:31 MHDA- 2026/10/06 17:32 CRDT- 2026/10/06 11:16 PHST- 2026/06/23 00:00 [received] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/08/27 00:00 [revised] PHST- 2026/10/06 17:32 [medline] PHST- 2026/10/06 17:31 [pubmed] PHST- 2026/10/06 11:16 [entrez] AID - 10.1007/s00431-026-07408-1 [pii] AID - 10.1007/s00431-026-07408-1 [doi] PST - epublish SO - Eur J Pediatr. 2026 Oct 6;185(11):806. doi: 10.1007/s00431-026-07408-1. PMID- 42836153 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261006 LR - 20261007 IS - 1680-5348 (Electronic) IS - 1020-4989 (Print) IS - 1020-4989 (Linking) VI - 50 DP - 2026 TI - Body weight perception and body self-esteem in adolescents with overweight or obesity in Costa Rica: challenges for public health policy. PG - e80 LID - 10.26633/RPSP.2026.80 [doi] LID - e80 AB - OBJECTIVE: This study estimates the prevalence of weight misperception among Costa Rican adolescents in general and examines its association with body esteem and weight-control behaviors to inform public health policy. METHODS: The authors analyzed cross-sectional data collected in 2017 from a probabilistic sample of 818 adolescents aged 13-18 years enrolled in public and private secondary schools in urban and rural areas of the province of San Jose, Costa Rica. Weight and height were measured by trained nutritionists and classified using World Health Organization body mass index (BMI)-for-age standards. Perceived weight status was assessed using culturally appropriate response categories adapted from the Youth Risk Behavior Survey and refined through a pilot study. Body esteem and weight-control behaviors were measured using validated survey instruments. RESULTS: Among adolescents with overweight or obesity, 59% underestimated their weight, most commonly perceiving themselves as having an "adequate weight." Weight underestimation was associated with higher body esteem and lower engagement in weight-control behaviors after adjustment for key sociodemographic characteristics. CONCLUSION: By contributing evidence from a Latin American context-where research on adolescent weight perception remains scarce-this study enhances understanding of how excess weight is perceived during adolescence in settings where overweight is highly prevalent and supports public policy approaches that prioritize healthy eating and active living from adolescence. FAU - Monge-Rojas, Rafael AU - Monge-Rojas R AD - Nutrition and Health Unit Costa Rican Institute for Research and Education on Nutrition and Health (INCIENSA) Ministry of Health Tres Rios 4-2250 Costa Rica Nutrition and Health Unit, Costa Rican Institute for Research and Education on Nutrition and Health (INCIENSA), Ministry of Health, Tres Rios 4-2250, Costa Rica. FAU - Smith-Castro, Vanessa AU - Smith-Castro V AD - Psychological Research Institute University of Costa Rica City of Research Montes de Oca 11501-2060 Costa Rica Psychological Research Institute, University of Costa Rica, City of Research, Montes de Oca 11501-2060, Costa Rica. FAU - Vargas-Quesada, Rulaman AU - Vargas-Quesada R AD - Nutrition and Health Unit Costa Rican Institute for Research and Education on Nutrition and Health (INCIENSA) Ministry of Health Tres Rios 4-2250 Costa Rica Nutrition and Health Unit, Costa Rican Institute for Research and Education on Nutrition and Health (INCIENSA), Ministry of Health, Tres Rios 4-2250, Costa Rica. LA - eng PT - Journal Article DEP - 20261005 PL - United States TA - Rev Panam Salud Publica JT - Revista panamericana de salud publica = Pan American journal of public health JID - 9705400 PMC - PMC13637699 OTO - NOTNLM OT - Adolescent OT - Latin America OT - body weight OT - obesity OT - overweight OT - weight perception COIS- Conflicts of interests. None declared. EDAT- 2026/10/06 11:31 MHDA- 2026/10/06 11:32 PMCR- 2026/10/05 CRDT- 2026/10/06 07:24 PHST- 2026/02/10 00:00 [received] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/10/06 11:32 [medline] PHST- 2026/10/06 11:31 [pubmed] PHST- 2026/10/06 07:24 [entrez] PHST- 2026/10/05 00:00 [pmc-release] AID - RPSP.2026.80 [pii] AID - 10.26633/RPSP.2026.80 [doi] PST - epublish SO - Rev Panam Salud Publica. 2026 Oct 5;50:e80. doi: 10.26633/RPSP.2026.80. eCollection 2026. PMID- 42835958 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261006 LR - 20261007 IS - 2772-4875 (Electronic) IS - 2772-4875 (Linking) VI - 31 DP - 2026 Dec TI - Early-onset atherosclerotic cardiovascular disease in young adults: Lifestyle, environmental, and psychosocial risk factors. PG - 200714 LID - 10.1016/j.ijcrp.2026.200714 [doi] LID - 200714 AB - Early-onset atherosclerotic cardiovascular disease (ASCVD) must be distinguished from cardiovascular risk factors and subclinical vascular abnormalities that may arise at younger ages. This narrative review critically examines lifestyle, environmental, metabolic, psychosocial, and inherited determinants among adolescents (10-19 years), young adults (20-39 years), and selected adults aged 40-54 years who remain within commonly used thresholds for premature events. The 40-54-year band is included selectively to bridge younger-adult prevention with guideline-based adult risk assessment and is not intended to redefine the upper age limit of premature ASCVD. Epidemiological evidence demonstrates a substantial burden of cardiovascular disease (CVD) among people aged 15-39 years; however, evidence of increasing clinically manifest ASCVD is less consistent than evidence of rising obesity, hypertension, dyslipidemia, diabetes, nicotine exposure, and subclinical vascular injury. Established causal drivers, including cumulative exposure to apolipoprotein B-containing lipoproteins and cigarette smoking, are distinguished from predominantly associative evidence concerning sleep disruption, psychosocial stress, e-cigarette use, and air pollution. Prevention should combine population-level health promotion with age-appropriate clinical risk assessment, including lipid screening and measurement of lipoprotein(a) at least once in adulthood, with additional targeted evaluation for familial hypercholesterolemia, a family history of premature ASCVD, obesity, hypertension, diabetes, chronic kidney disease, and smoking or vaping. Coronary artery calcium scoring and carotid imaging are not recommended as universal screening tests for asymptomatic young people, although they may refine clinical decisions in carefully selected adults. Digital tools may support engagement but should complement, rather than replace, validated clinical care and public-health measures. CI - (c) 2026 The Authors. FAU - Khasanovna, Tukhtaeva Nigora AU - Khasanovna TN AD - "Propaedeutics of Internal Diseases No. 2", Tashkent State Medical University, Tashkent, Uzbekistan. FAU - Egamberdi Son, Babajanov Xudoybergan AU - Egamberdi Son BX AD - Tashkent State Medical University, Tashkent, Uzbekistan. LA - eng PT - Journal Article PT - Review DEP - 20260924 PL - Netherlands TA - Int J Cardiol Cardiovasc Risk Prev JT - International journal of cardiology. Cardiovascular risk and prevention JID - 9918282077306676 PMC - PMC13636304 OTO - NOTNLM OT - Atherosclerotic cardiovascular disease OT - Familial hypercholesterolemia OT - Premature cardiovascular disease OT - Prevention OT - Risk assessment OT - Young adults OT - lipoprotein(a) EDAT- 2026/10/06 11:31 MHDA- 2026/10/06 11:32 PMCR- 2026/09/24 CRDT- 2026/10/06 07:06 PHST- 2026/05/13 00:00 [received] PHST- 2026/09/18 00:00 [revised] PHST- 2026/09/23 00:00 [accepted] PHST- 2026/10/06 11:32 [medline] PHST- 2026/10/06 11:31 [pubmed] PHST- 2026/10/06 07:06 [entrez] PHST- 2026/09/24 00:00 [pmc-release] AID - S2772-4875(26)00144-3 [pii] AID - 200714 [pii] AID - 10.1016/j.ijcrp.2026.200714 [doi] PST - epublish SO - Int J Cardiol Cardiovasc Risk Prev. 2026 Sep 24;31:200714. doi: 10.1016/j.ijcrp.2026.200714. eCollection 2026 Dec. PMID- 42835802 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261006 LR - 20261007 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Mediterranean diet, eating behaviours, and nutritional intervention in childhood obesity: what works, where, and for whom-a narrative review. PG - 1892494 LID - 10.3389/fnut.2026.1892494 [doi] LID - 1892494 AB - Childhood obesity is a leading public health challenge with rising global prevalence and significant impacts on cardiometabolic health extending into adulthood. Lifestyle intervention, with nutrition as its central component, is the main point of paediatric obesity management, yet the evidence base remains fragmented across regions, instruments, and clinical models. This narrative review synthesises European evidence on Mediterranean diet (MD) adherence assessment, multidisciplinary intervention outcomes, and global comparative patterns in paediatric obesity management. Among dietary patterns, the Mediterranean diet (MD) remains the most evidence-supported framework for cardiometabolic prevention in children and adolescents. KIDMED, a 16-item validated instrument, has been adapted for multiple European paediatric populations and consistently identifies low legume, whole grain, and extra-virgin olive oil intake as the principal adherence gaps associated with a higher body mass index (BMI) Z-score, as well as a higher age- and sex-specific BMI percentile. The Children's Eating Behaviour Questionnaire (CEBQ) provides a complementary behavioural marker with food-approach subscales positively associated with BMI Z-score and food-avoidance subscales inversely associated, a pattern replicated across European, Latin American, and Middle Eastern cohorts. Structured multidisciplinary interventions consistently produce modest reductions in BMI Z-score, typically between 0.10 and 0.25 units over 3 to 12 months. The strongest predictors of response are younger age, lower baseline obesity severity, breakfast adherence, and the absence of obese parents. Low KIDMED score additionally functions as a screening signal for paediatric Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD). Continental comparisons suggest that dietary-quality predictors of paediatric obesity are broadly consistent across regions. However, the feasibility of Mediterranean-style approaches varies substantially with local food availability, culinary traditions and economic access, so cross-cultural application of KIDMED-based screening requires careful local adaptation. The review concludes that routine integration of KIDMED and CEBQ within structured multidisciplinary pathways represents an evidence-informed, implementation-ready step for pediatric obesity care, particularly in under-studied Central and Eastern Europe. CI - Copyright (c) 2026 Bober and Gaszynska. FAU - Bober, Julia AU - Bober J AD - International Doctoral School, Medical University of Lodz, Lodz, Poland. AD - Department of Nutrition and Epidemiology, Medical University of Lodz, Lodz, Poland. FAU - Gaszynska, Ewelina AU - Gaszynska E AD - Department of Nutrition and Epidemiology, Medical University of Lodz, Lodz, Poland. LA - eng PT - Journal Article PT - Review DEP - 20260921 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13635886 OTO - NOTNLM OT - CEBQ OT - KIDMED OT - Mediterranean diet OT - childhood obesity OT - lifestyle intervention COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/06 11:31 MHDA- 2026/10/06 11:32 PMCR- 2026/09/21 CRDT- 2026/10/06 06:52 PHST- 2026/05/27 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/06 11:32 [medline] PHST- 2026/10/06 11:31 [pubmed] PHST- 2026/10/06 06:52 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - 10.3389/fnut.2026.1892494 [doi] PST - epublish SO - Front Nutr. 2026 Sep 21;13:1892494. doi: 10.3389/fnut.2026.1892494. eCollection 2026. PMID- 42835418 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261006 LR - 20261007 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Feasibility of FnNO measurement in preschoolers and development of predictive models. PG - 1891740 LID - 10.3389/fped.2026.1891740 [doi] LID - 1891740 AB - BACKGROUND: Fractional nasal exhaled nitric oxide (FnNO) is a valuable biomarker of upper airway mucosal inflammation, but its clinical application in preschoolers is limited by uncertain compliance and a lack of reference data. This study aimed to evaluate the feasibility of standardized FnNO measurement in children aged 3-6 years, identify independent predictors of test cooperation and first-attempt success to build exploratory predictive models, and provide preliminary distribution estimates of FnNO in healthy preschoolers. METHODS: A total of 148 preschoolers aged 3-6 years were enrolled. Test completion and first-attempt success rates were recorded. Multivariable logistic regression was used to identify independent predictors of compliance. Exploratory predictive models were developed and evaluated using receiver operating characteristic (ROC) analysis with internal bootstrap validation. FnNO distribution characteristics were analyzed in both the general cohort and a healthy subgroup. RESULTS: The overall test completion rate was 82.4% (122/148), and the first-attempt success rate was 76.2% (77/101). Multivariable analysis demonstrated that female sex (OR = 4.853, P = 0.004) and greater height (OR = 1.216, P = 0.000) were independent predictors of test completion. Age was the sole independent predictor of first-attempt success (OR = 2.299, P = 0.001). The predictive model for test completion (sex and height) achieved an area under the curve (AUC) of 0.870, while the first-attempt success model (age and BMI) yielded an AUC of 0.749. The median FnNO level was 315.50 ppb (IQR: 168.00-410.00 ppb) across the overall cohort and 324.00 ppb (IQR: 221.00-378.50 ppb) in the healthy subgroup (n = 81). CONCLUSIONS: Standardized FnNO measurement is feasible in preschool children. Height, sex, and age are key factors influencing test cooperation. The proposed predictive models offer exploratory statistical tools for population stratification in research contexts, though prospective clinical validation remains necessary. This study establishes preliminary reference estimates for FnNO in Chinese preschoolers. CI - (c) 2026 Wang, Lin, Wang and Li. FAU - Wang, Yue AU - Wang Y AD - Department of Pediatric Respiratory Medicine, Children's Medical Center, The First Hospital of Jilin University, Changchun, Jilin, China. FAU - Lin, Qianqian AU - Lin Q AD - Department of Pediatric Respiratory Medicine, Children's Medical Center, The First Hospital of Jilin University, Changchun, Jilin, China. FAU - Wang, Haoyu AU - Wang H AD - Department of Pediatric Respiratory Medicine, Children's Medical Center, The First Hospital of Jilin University, Changchun, Jilin, China. FAU - Li, Yanchun AU - Li Y AD - Department of Pediatric Respiratory Medicine, Children's Medical Center, The First Hospital of Jilin University, Changchun, Jilin, China. LA - eng PT - Journal Article DEP - 20260921 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13635358 OTO - NOTNLM OT - FnNO OT - children OT - compliance OT - feasibility OT - predictive model COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/06 11:31 MHDA- 2026/10/06 11:32 PMCR- 2026/09/21 CRDT- 2026/10/06 06:14 PHST- 2026/05/26 00:00 [received] PHST- 2026/09/07 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/06 11:32 [medline] PHST- 2026/10/06 11:31 [pubmed] PHST- 2026/10/06 06:14 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - 10.3389/fped.2026.1891740 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 21;14:1891740. doi: 10.3389/fped.2026.1891740. eCollection 2026. PMID- 42835024 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261006 LR - 20261007 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Diet quality in pediatric migraine and the educational quality of related short-form videos: a cross-sectional study and content analysis. PG - 1934926 LID - 10.3389/fnut.2026.1934926 [doi] LID - 1934926 AB - BACKGROUND: Diet quality has been associated with headache burden and psychosocial outcomes in children with migraine, while caregivers increasingly use short-form videos for dietary and lifestyle advice. However, evidence on overall diet quality and related video quality remains limited. METHODS: This study included 180 children aged 7-18 years with migraine. Diet quality was assessed using the Chinese Children Dietary Index (CCDI). Participants were divided at the median CCDI score of 117.7 into low- and high-CCDI groups (n = 90 each). Between-group comparisons included Pediatric Migraine Disability Assessment (PedMIDAS) scores, headache characteristics, analgesic use, caregiver burden, and anxiety and depressive symptoms. Multivariable regression was used to examine adjusted associations between CCDI scores and clinical outcomes. Caregiver use of short-form videos was also surveyed. In addition, 150 videos on dietary and lifestyle management of pediatric migraine from Douyin, Kuaishou, and Xiaohongshu were analyzed for educational quality, reliability, and actionability. RESULTS: The high-CCDI group had lower PedMIDAS scores than the low-CCDI group (29.54 +/- 17.20 vs. 41.96 +/- 14.72), fewer headache days over 28 days [6.00 (4.00, 8.00) vs. 9.00 (8.00, 11.00)], lower pain intensity, and fewer days of analgesic use (all p < 0.001). Caregiver burden and anxiety and depression scores were also lower (all p < 0.05). After adjustment, higher CCDI scores remained associated with lower PedMIDAS scores, fewer headache days, lower pain intensity, fewer days of analgesic use, and lower caregiver burden. Diet and lifestyle management was the most frequently searched topic (30.6%), yet only 34.4% of caregivers fully verified video recommendations with a physician. Although 90.0% of videos provided recommendations concordant with clinical guidelines or evidence-based recommendations, reliability, actionability, and nutrition follow-up remained limited; nutrition follow-up was addressed in only 23.33% of videos. CONCLUSION: Higher overall diet quality was associated with lower migraine burden and caregiver burden in children with migraine. These findings support the relevance of overall dietary assessment, while prospective studies are needed to clarify temporal and causal relationships. Short-form videos are an important source of dietary and lifestyle information for caregivers, but their reliability, actionability, and follow-up content require improvement. CI - Copyright (c) 2026 Li, Liu, Jiang, Xu, Zhou and Xu. FAU - Li, Haisu AU - Li H AD - Department of Anesthesiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing, China. FAU - Liu, Lan AU - Liu L AD - Department of Anesthesiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing, China. FAU - Jiang, Jiayi AU - Jiang J AD - Department of Anesthesiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing, China. FAU - Xu, Yumei AU - Xu Y AD - Department of Anesthesiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing, China. FAU - Zhou, Dan AU - Zhou D AD - Department of Anesthesiology, The Affiliated Dazu's Hospital of Chongqing Medical University, Chongqing, China. FAU - Xu, Ying AU - Xu Y AD - Department of Anesthesiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing, China. LA - eng PT - Journal Article DEP - 20260921 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13634853 OTO - NOTNLM OT - Chinese Children Dietary Index OT - diet quality OT - dietary management OT - pediatric migraine OT - short-form videos COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/06 11:31 MHDA- 2026/10/06 11:32 PMCR- 2026/09/21 CRDT- 2026/10/06 05:17 PHST- 2026/07/11 00:00 [received] PHST- 2026/08/14 00:00 [revised] PHST- 2026/09/01 00:00 [accepted] PHST- 2026/10/06 11:32 [medline] PHST- 2026/10/06 11:31 [pubmed] PHST- 2026/10/06 05:17 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - 10.3389/fnut.2026.1934926 [doi] PST - epublish SO - Front Nutr. 2026 Sep 21;13:1934926. doi: 10.3389/fnut.2026.1934926. eCollection 2026. PMID- 42833415 OWN - NLM STAT- Publisher LR - 20261010 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 76 DP - 2026 Oct 5 TI - Anthropometric profile, severity, and concordance of MUAC and BMI-for-age classification among clinically screened pediatric patients at a tertiary care hospital in south Rajasthan: A hospital-based cross-sectional study. PG - 105167 LID - S2405-4577(26)02264-3 [pii] LID - 10.1016/j.clnesp.2026.105167 [doi] AB - INTRODUCTION: Undernutrition remains a leading contributor to childhood morbidity and mortality in India, and southern Rajasthan - with a large rural and tribal catchment - carries a disproportionate burden. Data describing the anthropometric profile of malnourished children who actually reach tertiary care in this region are limited. AIM: To characterise the anthropometric profile and severity of malnutrition among children undergoing clinical screening at a tertiary care hospital in South Rajasthan, to classify nutritional status using age- and sex-specific WHO z-scores, to assess agreement between mid-upper arm circumference (MUAC) and BMI-for-age classification, and to examine associations between anthropometric, dietary, demographic and behavioural variables. MATERIALS AND METHODS: A hospital-based cross-sectional study was conducted in the Department of Pediatrics of a tertiary care teaching hospital in Udaipur, Rajasthan, over four months of data collection. One hundred and twenty-five children aged 6 months to 18 years, identified as malnourished on clinical screening, were enrolled by consecutive sampling. Weight, height, body mass index (BMI) and mid-upper arm circumference (MUAC) were measured by standard technique; habitual pre-illness dietary energy and protein intake were obtained by recall and compared with age-appropriate recommended allowances. Non-parametric tests, Chi-square, Spearman correlation and Cohen's kappa were used, with P < 0.05 considered significant. RESULTS: Of 125 children undergoing clinical screening (mean age 3.37 +/- 3.02 years; 59.2% male; 76.0% rural), age- and sex-specific WHO BMI-for-age z-scores (WHO Child Growth Standards for 6-60 months; WHO Growth Reference 2007 for 61-228 months) classified 31 (24.8%) as wasted and 78 (62.4%) as severely wasted, together 87.2%; 16 (12.8%) were normal. Mean BMI was 12.05 +/- 1.45 kg/m(2) and mean MUAC 12.77 +/- 2.23 cm. In the subgroup aged 6-59 months for whom WHO MUAC cut-offs are validated (n = 102), MUAC classified 31 (30.4%) as severe and 24 (23.5%) as moderate acute malnutrition; among the 91 children in this subgroup classified as wasted or severely wasted by BMI-for-age z-score, 42 (46.2%) had a MUAC value in the normal range. Agreement between MUAC and z-score-based BMI classification in this subgroup was negligible (linear-weighted kappa = 0.02; unweighted kappa = 0.03). Percentage calorie deficit correlated inversely with MUAC (rho = -0.608, P < 0.001), an association that persisted after adjusting for age (partial rho = -0.583, P < 0.001), but not with BMI. No demographic factor reached significance; age group approached it (P = 0.051). CONCLUSION: Among children undergoing clinical screening at this tertiary care centre in South Rajasthan, malnutrition was severe and predominantly acute on z-score-based BMI-for-age classification. Fixed MUAC cut-offs performed poorly outside the 6-59 month band for which they are validated, and a substantial proportion of children with acute malnutrition on BMI-for-age were not flagged by MUAC. These findings support the consideration of complementary anthropometric assessment - using MUAC alongside BMI/weight-for-height and age- and sex-specific WHO z-scores rather than raw cut-offs - particularly in primary and referral care settings serving a wide paediatric age range. CI - Copyright (c) 2026 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. FAU - Kumar, Dinesh AU - Kumar D AD - Department of Pharmacology, Pacific College of Pharmacy, Pacific Academy of Higher Education and Research University, Udaipur, Rajasthan, 313001, India. Electronic address: 2016dineshkr@gmail.com. FAU - Singh, Anukrman AU - Singh A AD - Department of Pharmacology, Pacific College of Pharmacy, Pacific Academy of Higher Education and Research University, Udaipur, Rajasthan, 313001, India. FAU - More, S S AU - More SS AD - Department of Pediatrics, Pacific Medical College and Hospital, Udaipur, Rajasthan, 313001, India. LA - eng PT - Journal Article DEP - 20261005 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM OTO - NOTNLM OT - Anthropometry OT - Child nutrition disorders OT - Cross-sectional studies OT - Mid-upper arm circumference OT - Rajasthan OT - Wasting syndrome COIS- Conflicts of interest There are no conflicts of interest. EDAT- 2026/10/05 23:30 MHDA- 2026/10/05 23:30 CRDT- 2026/10/05 19:32 PHST- 2026/08/07 00:00 [received] PHST- 2026/09/24 00:00 [revised] PHST- 2026/09/30 00:00 [accepted] PHST- 2026/10/05 23:30 [pubmed] PHST- 2026/10/05 23:30 [medline] PHST- 2026/10/05 19:32 [entrez] AID - S2405-4577(26)02264-3 [pii] AID - 10.1016/j.clnesp.2026.105167 [doi] PST - aheadofprint SO - Clin Nutr ESPEN. 2026 Oct 5;76:105167. doi: 10.1016/j.clnesp.2026.105167. PMID- 42830479 OWN - NLM STAT- MEDLINE DCOM- 20261005 LR - 20261005 IS - 1523-5378 (Electronic) IS - 1083-4389 (Linking) VI - 31 IP - 5 DP - 2026 Sep-Oct TI - Epidemiology of Helicobacter pylori and Gastric Atrophy in Rural Southwestern Uganda: The ENIGMA Uganda Study. PG - e70163 LID - 10.1111/hel.70163 [doi] AB - BACKGROUND: Characterizing the epidemiology of Helicobacter pylori (H. pylori) infection and gastric atrophy (GA) is essential for informing preventive strategies in anticipation of the rising gastric cancer burden. The International Agency for Research on Cancer has initiated global studies to characterize these epidemiological patterns using a standardized framework, including in Uganda. MATERIALS AND METHODS: This population-based study included 700 individuals aged 1-69 years, randomly selected from the General Population Cohort in rural Uganda, stratified by sex and age. Participants completed a structured questionnaire to assess risk factors related to H. pylori infection and GA, underwent anthropometric measurements, and provided blood samples. Anti-H. pylori IgG antibodies were measured using enzyme-linked immunosorbent assays (ELISA). In individuals aged >/= 40 years, plasma pepsinogen I (PG I) and pepsinogen II (PG II) concentrations were measured by ELISA to define gastric atrophy. RESULTS: The age-standardized H. pylori seroprevalence was 76%. The crude seroprevalence was 63% in children aged 1-9 years, rose to over 80% in individuals aged 10-39 years, and then declined modestly in older age groups (73% in individuals aged >/= 40). Men aged >/= 40 years had a lower H. pylori seroprevalence compared to women aged >/= 40 years (68% vs. 78%, p < 0.05). Serologically defined GA was uncommon, with an overall prevalence of 6% (17/301; 95% CI: 3%-9%) among individuals aged >/= 40 years. Obesity (aOR 6.0, 95% CI 1.6-20.9) and less than daily chili consumption (aOR 4.3, 95% CI 1.4-14.9) were associated with higher odds of GA among participants aged >/= 40 years, after adjustment for age and sex. CONCLUSIONS: In this population-based study in rural southwestern Uganda, H. pylori infection was acquired early in life and was highly prevalent, whereas serologically defined gastric atrophy remained relatively uncommon. This distinct epidemiological pattern warrants further validation and investigation. CI - (c) 2026 John Wiley & Sons Ltd. The WHO International Agency for Research on Cancer retains copyright and all other rights in the manuscript of this article as submitted for publication. FAU - Huang, Yue AU - Huang Y AUID- ORCID: 0000-0002-0864-8990 AD - Early Detection, Prevention and Infections Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France. FAU - Knaze, Viktoria AU - Knaze V AUID- ORCID: 0000-0002-9646-2052 AD - Early Detection, Prevention and Infections Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France. FAU - Mugisha, Joseph AU - Mugisha J AD - Uganda Research Unit, MRC/UVRI and LSHTM, Entebbe, Uganda. FAU - Navionis, Anne-Sophie AU - Navionis AS AUID- ORCID: 0009-0002-9854-1114 AD - Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France. FAU - Rinaldi, Sabina AU - Rinaldi S AUID- ORCID: 0000-0002-6846-1204 AD - Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France. FAU - Clifford, Gary M AU - Clifford GM AUID- ORCID: 0000-0001-7534-333X AD - Early Detection, Prevention and Infections Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France. FAU - Park, Jin Young AU - Park JY AUID- ORCID: 0000-0003-2491-5099 AD - Early Detection, Prevention and Infections Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France. FAU - Newton, Robert AU - Newton R AD - Uganda Research Unit, MRC/UVRI and LSHTM, Entebbe, Uganda. AD - University of York, York, UK. LA - eng GR - Centre International de Recherche sur le Cancer/ PT - Journal Article PL - England TA - Helicobacter JT - Helicobacter JID - 9605411 RN - 0 (Antibodies, Bacterial) RN - 9001-10-9 (Pepsinogen A) SB - IM MH - Humans MH - Uganda/epidemiology MH - *Helicobacter Infections/epidemiology/complications MH - Female MH - Male MH - Adult MH - Middle Aged MH - Adolescent MH - Child MH - Child, Preschool MH - *Helicobacter pylori/isolation & purification/immunology MH - Aged MH - Young Adult MH - Infant MH - Rural Population MH - Seroepidemiologic Studies MH - Antibodies, Bacterial/blood MH - *Gastritis, Atrophic/epidemiology MH - Pepsinogen A/blood MH - Risk Factors MH - Prevalence MH - Enzyme-Linked Immunosorbent Assay OTO - NOTNLM OT - Helicobacter pylori OT - gastric atrophy OT - pepsinogen OT - prevalence EDAT- 2026/10/05 05:31 MHDA- 2026/10/05 05:32 CRDT- 2026/10/05 00:33 PHST- 2026/08/12 00:00 [revised] PHST- 2026/06/16 00:00 [received] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/05 05:32 [medline] PHST- 2026/10/05 05:31 [pubmed] PHST- 2026/10/05 00:33 [entrez] AID - 10.1111/hel.70163 [doi] PST - ppublish SO - Helicobacter. 2026 Sep-Oct;31(5):e70163. doi: 10.1111/hel.70163. PMID- 42829788 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261004 LR - 20261005 IS - 2277-9531 (Print) IS - 2319-6440 (Electronic) IS - 2277-9531 (Linking) VI - 15 DP - 2026 TI - Design and implementation of a pediatric failure to thrive registry system in Iran. PG - 366 LID - 10.4103/jehp.jehp_852_25 [doi] LID - 366 AB - BACKGROUND: Failure to thrive (FTT) refers to inadequate growth caused by an inability to acquire or use enough calories for growth. It refers to a failure to develop over time, which can lead to more serious problems in adulthood if left untreated. FTT is a significant global health concern, particularly in developing countries like Iran. Effective FTT management necessitates timely, inclusive, and precise data on children's FTT status. A pediatric FTT registry system is a useful tool for gathering and managing data on children with FTT. This study proposes a pediatric FTT registry system for Iran. MATERIALS AND METHODS: A developmental-applied study was conducted in three phases during 2024. The first phase involved defining the features of a pediatric FTT registry system through interviews with experts. The second phase entailed expert validation using the Delphi method. In the third phase, the software was designed based on a conceptual model using the Hypertext Preprocessor programming language and the Laravel framework. PostgreSQL was employed as the database management system. Moreover, Nielsen's Ten Usability Heuristics was used to evaluate the software's usability from the users' perspectives. RESULTS: Experts validated the features of the pediatric FTT registry system, resulting in a framework that included eight headings, 24 sub-headings, and 117 data elements. The usability assessment of the software revealed that the highest number of issues concerned the "error prevention" indicator, whereas the "aesthetic and minimalist design" indicator presented the fewest problems and was assumed flawless. CONCLUSION: A pediatric FFT registry system contributes significantly to service planning, management, disease surveillance, and research. Accordingly, future research is recommended to investigate the feasibility of implementing the pediatric FFT registry system in Iran. CI - Copyright: (c) 2026 Journal of Education and Health Promotion. FAU - Khademi, Sahar AU - Khademi S AD - Department of Health Information Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran. FAU - Langarizadeh, Mostafa AU - Langarizadeh M AD - Department of Health Information Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran. FAU - Sheikhtaheri, Abbas AU - Sheikhtaheri A AD - Health Management and Economics Research Center, Health Management Research Institute, Iran University of Medical Sciences, Tehran, Iran. LA - eng PT - Journal Article DEP - 20260831 PL - India TA - J Educ Health Promot JT - Journal of education and health promotion JID - 101593794 PMC - PMC13633805 OTO - NOTNLM OT - Failure to thrive OT - failure to thrive registry OT - low weight OT - registry OT - registry system OT - stunting COIS- There are no conflicts of interest. EDAT- 2026/10/04 05:36 MHDA- 2026/10/04 05:37 PMCR- 2026/08/31 CRDT- 2026/10/04 04:15 PHST- 2025/05/08 00:00 [received] PHST- 2025/07/29 00:00 [accepted] PHST- 2026/10/04 05:37 [medline] PHST- 2026/10/04 05:36 [pubmed] PHST- 2026/10/04 04:15 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - JEHP-15-366 [pii] AID - 10.4103/jehp.jehp_852_25 [doi] PST - epublish SO - J Educ Health Promot. 2026 Aug 31;15:366. doi: 10.4103/jehp.jehp_852_25. eCollection 2026. PMID- 42829327 OWN - NLM STAT- Publisher LR - 20261003 IS - 1751-8431 (Electronic) IS - 1751-8423 (Linking) DP - 2026 Oct 3 TI - Clinical Relevance of the Eating and Drinking Ability Classification System in Young Children with Cerebral Palsy: Associations with Child and Family Outcomes Relevant to Rehabilitation. PG - 1-9 LID - 10.1080/17518423.2026.2738684 [doi] AB - BACKGROUND: The Eating and Drinking Ability Classification System (EDACS) is a validated functional classification system for assessing feeding ability in individuals with cerebral palsy (CP). Its clinical relevance in relation to broader child and family outcomes has received limited attention, particularly in young children. This study evaluated associations between EDACS and motor function, communication ability, nutritional status, behavioral profile and caregiver quality of life in young children with CP. METHODS: This cross-sectional study included 100 children aged 18-60 months with CP attending a tertiary Child Development Center in North India. Of these, 49 (49%) were aged 18-35 months and 51 (51%) were aged 36-60 months; 49 (49%) were classified as GMFCS Levels IV-V. Feeding ability was classified using age-appropriate EDACS descriptors. Gross motor function and communication were assessed using GMFCS and CFCS, respectively. Nutritional status was assessed using weight-for-length/height Z scores, mid-upper arm circumference and clinical pallor. Behavioral problems and caregiver quality of life were evaluated using the Child Behavior Checklist and WHOQOL-BREF, respectively. Associations were assessed using Kruskal-Wallis and Fisher's exact tests, Spearman's rank correlation, cumulative ordinal logistic regression and linear regression. RESULTS: Increasing EDACS level was associated with poorer nutritional status, including lower weight-for-length/height Z scores, reduced mid-upper arm circumference and higher prevalence of clinical pallor (all p classroom academic emotions --> classroom attention) was not significant. This study provides evidence that 15-min recess freestyle rope skipping is associated with improvements in middle school students' classroom attention and improve their emotional states, with the intervention effects moderated by grade level and activity format. This study provides empirical evidence for the fields of physical activity, emotion, and attention, and offers practical guidance for optimizing recess physical activities and promoting healthy school development in secondary schools. CI - Copyright (c) 2026 Li, Chen, Cen and Liu. FAU - Li, Jianmin AU - Li J AD - College of Physical Education, Hefei University of Technology, Hefei, China. FAU - Chen, Xiaoting AU - Chen X AD - College of Physical Education, Yangzhou University, Yangzhou, China. FAU - Cen, Wei AU - Cen W AD - College of Physical Education, Yangzhou University, Yangzhou, China. FAU - Liu, Chao AU - Liu C AD - College of Physical Education, Yangzhou University, Yangzhou, China. LA - eng PT - Journal Article DEP - 20260918 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13630699 OTO - NOTNLM OT - 15-min recess OT - classroom academic emotions OT - classroom attention OT - freestyle rope skipping OT - healthy school development COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/04 00:33 MHDA- 2026/10/04 00:34 PMCR- 2026/09/18 CRDT- 2026/10/03 05:49 PHST- 2026/06/11 00:00 [received] PHST- 2026/08/16 00:00 [revised] PHST- 2026/08/30 00:00 [accepted] PHST- 2026/10/04 00:34 [medline] PHST- 2026/10/04 00:33 [pubmed] PHST- 2026/10/03 05:49 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1906224 [doi] PST - epublish SO - Front Psychol. 2026 Sep 18;17:1906224. doi: 10.3389/fpsyg.2026.1906224. eCollection 2026. PMID- 42827730 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261003 LR - 20261005 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Predicting multiple mental health outcomes in adolescents using explainable machine learning models. PG - 1923390 LID - 10.3389/fpsyt.2026.1923390 [doi] LID - 1923390 AB - INTRODUCTION: Adolescent mental health problems, including depression, anxiety, and stress, are an increasing public health concern, yet the factors associated with different mental health outcomes may vary across domains. This study investigated shared and outcome-specific predictive features of depression, anxiety, perceived stress, and psychological well-being using explainable machine learning models. METHODS: A cross-sectional study was conducted among 1,088 adolescents aged 13-18 years recruited from secondary schools in Wuhan, China, using multistage cluster sampling. Participants completed validated measures of emotional dysregulation, loneliness, social media addiction, self-esteem, sleep quality, academic stress, family support, physical activity, and mental health outcomes. Four algorithms-linear regression, support vector regression, Random Forest, and XGBoost-were trained using an 80/20 train-test split with five-fold cross-validation, and model performance was evaluated using test-set R(2), RMSE, and MAE. SHapley Additive exPlanations (SHAP) were used to examine feature contributions. To minimize target leakage, outcome-specific feature sets were used, with PSQI and RSES excluded from the depression model because of direct or substantial conceptual overlap with PHQ-9 content, and PSQI excluded from the well-being model because of overlap with WHO-5 content. RESULTS: XGBoost showed the strongest out-of-sample predictive performance across all four outcomes, explaining 49% of the variance in depression (R(2) = 0.49, 95% CI: 0.44-0.53; RMSE = 3.52; MAE = 2.81), 55% in anxiety (R(2) = 0.55, 95% CI: 0.50-0.59; RMSE = 3.04; MAE = 2.47), 60% in perceived stress (R(2) = 0.60, 95% CI: 0.56-0.64; RMSE = 3.71; MAE = 2.87), and 50% in psychological well-being (R(2) = 0.50, 95% CI: 0.45-0.54; RMSE = 3.38; MAE = 2.68). DISCUSSION: Emotional dysregulation and loneliness were consistently among the most influential features, while academic stress, family support, social media addiction, self-esteem, and sleep quality showed outcome-specific contributions. SHAP rankings for the depression model were stable across five-fold cross-validation, with emotional dysregulation and loneliness consistently occupying the highest ranks. CI - Copyright (c) 2026 Dong, Meng, Wang, Yan and Liu. FAU - Dong, Xiaojie AU - Dong X AD - Department of Psychiatry, Ward 1, Wuhan Mental Health Center, Wuhan, Hubei, China. FAU - Meng, Jing AU - Meng J AD - Department of Psychiatry, Ward 1, Wuhan Mental Health Center, Wuhan, Hubei, China. FAU - Wang, Peng AU - Wang P AD - Department of Psychiatry, Ward 1, Wuhan Mental Health Center, Wuhan, Hubei, China. FAU - Yan, Chuandong AU - Yan C AD - Department of Psychiatry, Ward 1, Wuhan Mental Health Center, Wuhan, Hubei, China. FAU - Liu, Xiaobo AU - Liu X AD - Department of Medical Administration, Wuhan Mental Health Center, Wuhan, Hubei, China. LA - eng PT - Journal Article DEP - 20260918 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13631644 OTO - NOTNLM OT - adolescent OT - emotional dysregulation OT - loneliness OT - machine learning OT - mental health OT - predictive modeling COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/04 00:33 MHDA- 2026/10/04 00:34 PMCR- 2026/09/18 CRDT- 2026/10/03 05:43 PHST- 2026/06/29 00:00 [received] PHST- 2026/08/22 00:00 [revised] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/10/04 00:34 [medline] PHST- 2026/10/04 00:33 [pubmed] PHST- 2026/10/03 05:43 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1923390 [doi] PST - epublish SO - Front Psychiatry. 2026 Sep 18;17:1923390. doi: 10.3389/fpsyt.2026.1923390. eCollection 2026. PMID- 42827615 OWN - NLM STAT- MEDLINE DCOM- 20261003 LR - 20261006 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - A novel method based on ultrasound radiomics for predicting attainment of near-adult height in adolescents. PG - 1925196 LID - 10.3389/fendo.2026.1925196 [doi] LID - 1925196 AB - OBJECTIVE: This study aimed to develop and validate a novel ultrasound radiomics model for predicting the attainment of near-adult height (NAH) in adolescents. METHODS: This dual-center prospective cohort study enrolled 192 adolescents aged 11.0-18.0 years. Standardized ultrasound examinations of the ulnar growth plate region were performed, and 475 radiomic features were extracted. Feature selection was conducted using Least Absolute Shrinkage and Selection Operator (LASSO) algorithm with 5-fold cross-validation. Seven machine learning algorithms were compared to develop predictive models. Three models were constructed: clinical (sex and bone age), radiomics (Rad-score), and combined (sex, bone age, and Rad-score). Model performance was evaluated using area under the receiver operating characteristic curve, accuracy, sensitivity, specificity, calibration curves, and decision curve analysis. RESULTS: Three stable radiomic features were selected with selection frequency >/=80%: wavelet-LH_glcm_Imc2, wavelet-LL_ngtdm_Busyness, and wavelet-HL_firstorder_Energy. The combined model demonstrated superior performance, achieving AUCs of 0.981 (95% CI: 0.948-1.000) in the validation set, with sensitivity of 90% and specificity of 100%. Multivariate analysis identified independent positive predictors including Rad-score (OR = 3.28, P = 0.013) and bone age (OR = 2.65, P < 0.001). And male sex was a significant negative predictor (OR = 0.15, P = 0.005). CONCLUSION: The combined ultrasound radiomics machine learning model achieved excellent predictive performance for NAH attainment in adolescents. The non-ionizing ultrasound approach enables repeated dynamic monitoring, and the derived nomogram facilitates individualized risk stratification in routine pediatric practice. CI - Copyright (c) 2026 Zhang, Zhao, Sun, Zhang, Yang, Pan, Chen, Li and Yang. FAU - Zhang, Yixuan AU - Zhang Y AD - Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Zhao, Zeqing AU - Zhao Z AD - Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Sun, Yuxin AU - Sun Y AD - Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Zhang, Li AU - Zhang L AD - Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Yang, Yamei AU - Yang Y AD - Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Pan, Hui AU - Pan H AD - Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Chen, Shi AU - Chen S AD - Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Li, Jianchu AU - Li J AD - Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Yang, Xiao AU - Yang X AD - Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. AD - Zhangzhou Municipal Hospital Affiliated to Fujian Medical University, Zhangzhou, Fujian, China. LA - eng PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20260918 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Body Height/physiology MH - *Growth Plate/diagnostic imaging MH - Machine Learning MH - Prospective Studies MH - *Radiomics MH - Ultrasonography/methods PMC - PMC13630604 OTO - NOTNLM OT - adolescent growth assessment OT - machine learning OT - near-adult height OT - predictive model OT - ultrasound radiomics COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/04 00:33 MHDA- 2026/10/04 00:34 PMCR- 2026/09/18 CRDT- 2026/10/03 05:29 PHST- 2026/07/01 00:00 [received] PHST- 2026/08/31 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/04 00:34 [medline] PHST- 2026/10/04 00:33 [pubmed] PHST- 2026/10/03 05:29 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - 10.3389/fendo.2026.1925196 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Sep 18;17:1925196. doi: 10.3389/fendo.2026.1925196. eCollection 2026. PMID- 42827605 OWN - NLM STAT- MEDLINE DCOM- 20261003 LR - 20261005 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Near-final adult height after GnRHa plus growth hormone in central precocious puberty: a single-center cohort study and predicted adult height validation audit. PG - 1885575 LID - 10.3389/fendo.2026.1885575 [doi] LID - 1885575 AB - BACKGROUND: Whether adjunctive recombinant human growth hormone (rhGH) improves near-final adult height (NFAH) during gonadotropin-releasing hormone analog (GnRHa) therapy for central precocious puberty (CPP) remains uncertain, and predicted adult height (PAH) may reflect treatment selection and prognosis. METHODS: We analyzed a single-center retrospective cohort of 235 children with CPP who initiated GnRHa between January 2018 and December 2020. The primary endpoint was chart-recorded NFAH in the female-only maturity-ascertained cohort (n = 91); the criterion-confirmed all-sex set included 94 patients. The primary adjusted model (M2) included treatment, baseline age, body mass index (BMI), IGF-1, BA-CA, and baseline height; baseline bone age was not entered separately because bone age = chronological age + BA-CA. Missing baseline covariates were handled using 20 imputations by chained equations. Height gain and change in height standard deviation score (SDS) from baseline to 24 months were secondary outcomes. Results: Mean NFAH was 160.17 cm with GnRHa alone and 161.87 cm with GnRHa + rhGH. The adjusted M2 association was +2.26 cm (95% CI 0.12 to 4.40); the chart-PAH-conditioned M3 estimate was +0.58 cm (-1.60 to 2.75) and was treated as diagnostic. At 24 months, M2 estimates were +3.23 cm (2.00 to 4.46) for height gain, +3.24 cm (2.03 to 4.46) in analysis of covariance (ANCOVA) of attained height, and +0.46 SDS (0.27 to 0.66). In the criterion-confirmed female bone-age cohort, M2 estimates were +0.00 years (-0.27 to 0.27) for bone age at 24 months and -0.14 years (-0.30 to 0.03) for bone-age progression. CONCLUSIONS: Adjunctive rhGH was associated with greater growth over 24 months and a positive, imprecisely estimated NFAH difference. Because this was an observational study, ascertainment criteria were heterogeneous, and the NFAH estimate was sensitive to PAH adjustment and criterion restriction, the adult-height finding should be interpreted cautiously. CI - Copyright (c) 2026 Jin, Wang, Qian, Zhang, Liu and Yang. FAU - Jin, Peili AU - Jin P AD - Jiaxing Maternity and Child Health Care Hospital, Jiaxing, Zhejiang, China. FAU - Wang, Duomei AU - Wang D AD - Jiaxing Maternity and Child Health Care Hospital, Jiaxing, Zhejiang, China. FAU - Qian, Minyan AU - Qian M AD - Jiaxing Maternity and Child Health Care Hospital, Jiaxing, Zhejiang, China. FAU - Zhang, Huimin AU - Zhang H AD - Jiaxing Maternity and Child Health Care Hospital, Jiaxing, Zhejiang, China. FAU - Liu, Chang AU - Liu C AD - Medical Affairs Department, GeneScience Pharmaceuticals, Changchun, Jilin, China. FAU - Yang, Rongwei AU - Yang R AD - Jiaxing Maternity and Child Health Care Hospital, Jiaxing, Zhejiang, China. LA - eng PT - Journal Article DEP - 20260918 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 33515-09-2 (Gonadotropin-Releasing Hormone) RN - 12629-01-5 (Human Growth Hormone) RN - 0 (Puberty Inhibitors) SB - IM MH - Humans MH - *Puberty, Precocious/drug therapy MH - Female MH - *Body Height/drug effects MH - *Gonadotropin-Releasing Hormone/analogs & derivatives/therapeutic use/administration & dosage MH - Retrospective Studies MH - *Human Growth Hormone/administration & dosage/therapeutic use MH - Puberty Inhibitors MH - Child MH - Puberty Suppression MH - Male MH - Cohort Studies MH - Prognosis MH - Adult PMC - PMC13630612 OTO - NOTNLM OT - central precocious puberty OT - confounding by indication OT - gonadotropin-releasing hormone analog OT - growth hormone OT - near-final adult height OT - observational methods OT - predicted adult height OT - validation audit COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/04 00:33 MHDA- 2026/10/04 00:34 PMCR- 2026/09/18 CRDT- 2026/10/03 05:28 PHST- 2026/05/19 00:00 [received] PHST- 2026/08/03 00:00 [revised] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/10/04 00:34 [medline] PHST- 2026/10/04 00:33 [pubmed] PHST- 2026/10/03 05:28 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - 10.3389/fendo.2026.1885575 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Sep 18;17:1885575. doi: 10.3389/fendo.2026.1885575. eCollection 2026. PMID- 42825020 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261003 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - Liver transplantation-related osteoporosis and fragility fractures: pathogenic pathways, risk stratification and novel targeted therapy advances. PG - 1965784 LID - 10.3389/fimmu.2026.1965784 [doi] LID - 1965784 AB - Liver transplantation (LT) serves as the definitive treatment for end-stage liver disease. Yet, osteoporosis (OP) and fragility fractures remain frequently overlooked skeletal complications that may impair the long-term prognosis of recipients. This review systematically summarizes recent evidence regarding epidemiological characteristics, multifactorial pathogenic pathways, risk stratification approaches, and advances in targeted interventions for LT-related bone disorders. Skeletal damage distributes across pre-transplant waiting, early post-transplant acute and long-term chronic phases; rapid bone loss and elevated fracture risk potentially peak within the first year after LT. Pre-transplant hepatic dysfunction-induced malnutrition, endocrine disturbance, and chronic inflammation lay baseline skeletal impairment. In contrast, perioperative high-dose glucocorticoids, calcineurin inhibitor toxicity, surgical denervation, and ischemia-reperfusion injury may jointly drive substantial elevation of bone turnover in the early post-transplant stage. Long-term cortical bone repair deficiency could be attributed to persistent secondary hyperparathyroidism, post-transplant diabetes, and genetic susceptibility. Dual-energy X-ray absorptiometry remains the standard bone mineral density diagnostic tool, while vertebral computed tomography attenuation value and simplified clinical scoring systems support auxiliary risk stratification for skeletal health. Generalized nutritional and lifestyle interventions combined with anti-resorptive agents form mainstream management schemes; DKK-1/Wnt/beta-catenin pathway-targeted therapy shows potential as a novel intervention direction. Pediatric LT recipients feature unique bone maturation characteristics that require age-specific evaluation criteria, though unified standardized protocols remain insufficient. Current clinical practice suffers from inadequate bone health screening and pharmacotherapy coverage. Further prospective trials are warranted to validate optimized stratified screening algorithms and individualized targeted regimens for high-risk LT populations. CI - Copyright (c) 2026 Wang and Wang. FAU - Wang, Meiqi AU - Wang M AD - Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, China. FAU - Wang, Qi AU - Wang Q AD - Department of Donation Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. LA - eng PT - Journal Article PT - Review DEP - 20260917 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 SB - IM MH - Humans MH - *Liver Transplantation/adverse effects MH - *Osteoporosis/etiology/therapy/epidemiology/diagnosis MH - *Osteoporotic Fractures/etiology/therapy MH - Risk Assessment MH - Risk Factors MH - Animals MH - Bone Density PMC - PMC13628645 OTO - NOTNLM OT - Wnt/beta-Catenin pathway OT - bone mineral density OT - fragility fracture OT - hepatic osteodystrophy OT - liver transplantation OT - osteoporosis OT - risk stratification COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/02 13:37 MHDA- 2026/10/02 13:38 PMCR- 2026/09/17 CRDT- 2026/10/02 07:06 PHST- 2026/08/12 00:00 [received] PHST- 2026/09/01 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/02 13:38 [medline] PHST- 2026/10/02 13:37 [pubmed] PHST- 2026/10/02 07:06 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1965784 [doi] PST - epublish SO - Front Immunol. 2026 Sep 17;17:1965784. doi: 10.3389/fimmu.2026.1965784. eCollection 2026. PMID- 42824923 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261003 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Predictors of treatment response to semaglutide for weight management. PG - 1893511 LID - 10.3389/fendo.2026.1893511 [doi] LID - 1893511 AB - The emergence of weekly, injectable glucagon-like peptide-1 (GLP-1) receptor agonists has revolutionized the obesity management landscape. Numerous studies have shown high efficacy as well as great variability in weight loss, highlighting the need for this mini review, summarizing current evidence about predictors of semaglutide-related weight loss. The first well-known determinant of semaglutide-induced weight loss is the presence of type 2 DM which is associated with significantly lower body weight reduction. The second predictor is sex, with females exhibiting a greater weight loss than males by a mean 6%. In addition, higher maintenance dose of 7.2 mg is superior to standard 2.4 mg dose in weight reduction by a mean 3%. There is no clear association of age and baseline body mass index with the magnitude of semaglutide-driven weight loss, except for the possibility of adolescence enhancing and overweight reducing this treatment effect. The potential impact of genetic polymorphisms of individual treatment response to semaglutide remains incompletely understood, limited so far to a modest effect of specific variants in GLP1 receptor gene. Another potential predictor of response could be obesity phenotype, with preliminary data supporting greater effectiveness of semaglutide in individuals with ''hungry gut'' phenotype. Type of lifestyle modification does not seem to have a significant effect on the variability of semaglutide-driven weight loss. Further studies are needed to expand knowledge about predictors of response to semaglutide, paving the way for validated predictive models in order to guide clinical decision-making and provision of personalized obesity care. CI - Copyright (c) 2026 Tzoulis. FAU - Tzoulis, Ploutarchos AU - Tzoulis P AD - Research Department of Experimental and Translational Medicine, University College London, London, United Kingdom. LA - eng PT - Journal Article PT - Review DEP - 20260917 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 53AXN4NNHX (Semaglutide) RN - 62340-29-8 (Glucagon-Like Peptides) RN - 0 (Anti-Obesity Agents) RN - 0 (Glucagon-Like Peptide-1 Receptor Agonists) RN - 0 (Glucagon-Like Peptide-1 Receptor) SB - IM MH - Semaglutide MH - Humans MH - *Glucagon-Like Peptides/therapeutic use MH - *Obesity/drug therapy MH - *Weight Loss/drug effects MH - *Anti-Obesity Agents/therapeutic use MH - Diabetes Mellitus, Type 2/drug therapy MH - Glucagon-Like Peptide-1 Receptor Agonists MH - Treatment Outcome MH - Glucagon-Like Peptide-1 Receptor/genetics PMC - PMC13628350 OTO - NOTNLM OT - GLP-1 agonist OT - antiobesity agent OT - obesity OT - semaglutide OT - weight loss COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/02 13:36 MHDA- 2026/10/02 13:37 PMCR- 2026/09/17 CRDT- 2026/10/02 06:56 PHST- 2026/05/28 00:00 [received] PHST- 2026/07/14 00:00 [revised] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/10/02 13:37 [medline] PHST- 2026/10/02 13:36 [pubmed] PHST- 2026/10/02 06:56 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - 10.3389/fendo.2026.1893511 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Sep 17;17:1893511. doi: 10.3389/fendo.2026.1893511. eCollection 2026. PMID- 42824878 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261002 LR - 20261003 IS - 1662-5161 (Print) IS - 1662-5161 (Electronic) IS - 1662-5161 (Linking) VI - 20 DP - 2026 TI - Development, validation and effectiveness of a parents led neuromotor training module with AI-based movement analysis for improving motor proficiency and sports participation in children with developmental coordination disorder: a protocol for an assessor-blinded randomized superiority controlled trial. PG - 1931622 LID - 10.3389/fnhum.2026.1931622 [doi] LID - 1931622 AB - INTRODUCTION: Developmental Coordination Disorder (DCD) is a common neurodevelopmental condition characterized by impaired motor coordination, poor balance, reduced participation in physical activities, and limitations in functional performance. Conventional rehabilitation often requires prolonged therapist supervision and may not be consistently accessible, particularly in resource-limited settings. Parent-led rehabilitation and artificial intelligence (AI)-based movement analysis have emerged as promising approaches to enhance motor outcomes; however, evidence integrating these strategies remains limited. This manuscript presents the protocol for a randomized controlled trial evaluating a structured Parent-Led Neuromotor Training Programme integrated with AI-based movement analysis in children with DCD. METHODS AND ANALYSIS: This protocol describes an assessor-blinded, two-arm, parallel-group randomized superiority controlled trial involving 62 children aged 7-14 years diagnosed with DCD according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria and scoring below the age-expected range on the Movement Assessment Battery for Children-Second Edition (MABC-2). Participants will be randomly allocated (1:1) to either an intervention group receiving a Parent-Led Neuromotor Training Programme integrated with AI-based movement analysis in addition to conventional physiotherapy or a control group receiving conventional physiotherapy alone. Parents will deliver supervised home-based training for 30-45 min per session, 5 days per week, for 12 weeks. Movement analysis will be performed using Google MediaPipe Pose, a validated markerless pose-estimation framework, to quantify joint kinematics, movement symmetry, coordination, movement smoothness, movement accuracy, movement speed, and task-completion time from standardized video recordings. The primary outcome will be motor proficiency, assessed using the Bruininks-Oseretsky Test of Motor Proficiency, Second Edition (BOT-2). Secondary outcomes will include AI-based movement metrics such as symmetry index, movement variability, and coordination score, as well as parental adherence, engagement, satisfaction, balance, and agility outcomes, parental adherence and satisfaction, and AI-derived movement metrics. The sample size was calculated to detect a clinically meaningful between-group difference with 80% power at a 5% significance level. Statistical analyses will follow the intention-to-treat principle, with linear mixed-effects models used to compare repeated measurements between groups. Missing data will be handled using appropriate imputation methods where necessary. CLINICAL TRIAL REGISTRATION: https://ctri.nic.in/Clinicaltrials/regtrial.php?trialid=164461&EncHid=98252.11023&modid=1&compid=19 Identifier [CTRI/2026/06/112632]. CI - Copyright (c) 2026 Hullumani and Qureshi. FAU - Hullumani, Sharath AU - Hullumani S AD - Department of Pediatrics Physiotherapy, Ravi Nair Physiotherapy College, Datta Meghe Institute Higher Education and Research (DU), Wardha, India. FAU - Qureshi, Irshad AU - Qureshi I AD - Department of Neuro Physiotherapy, Ravi Nair Physiotherapy College, Datta Meghe Institute Higher Education and Research (DU), Wardha, India. LA - eng PT - Journal Article DEP - 20260911 PL - Switzerland TA - Front Hum Neurosci JT - Frontiers in human neuroscience JID - 101477954 PMC - PMC13628172 OTO - NOTNLM OT - DCD OT - artificial intelligence OT - developmental coordiantion disorder OT - media pipe OT - neuromotor training OT - parent led OT - physical therapy OT - therapist supervision COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/02 13:37 MHDA- 2026/10/02 13:38 PMCR- 2026/09/11 CRDT- 2026/10/02 06:52 PHST- 2026/07/08 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/10/02 13:38 [medline] PHST- 2026/10/02 13:37 [pubmed] PHST- 2026/10/02 06:52 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - 10.3389/fnhum.2026.1931622 [doi] PST - epublish SO - Front Hum Neurosci. 2026 Sep 11;20:1931622. doi: 10.3389/fnhum.2026.1931622. eCollection 2026. PMID- 42824331 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261003 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Predicting metabolic syndrome in adolescents from device-measured 24-h movement behaviors: a machine learning approach. PG - 1928562 LID - 10.3389/fpubh.2026.1928562 [doi] LID - 1928562 AB - OBJECTIVE: To develop and internally evaluate a non-invasive machine-learning model for identifying metabolic syndrome (MS) in adolescents using 24-h movement behaviors and non-invasively measured physical characteristics. METHODS: This cross-sectional study included 822 adolescents aged 12-15 years recruited in Tianjin, China, from September 2023 to September 2025. Movement behaviors were assessed using ActiGraph GT3X+ accelerometers, body composition was measured using dual-energy X-ray absorptiometry, and MS was diagnosed according to the 2007 International Diabetes Federation criteria. LASSO regression was used for feature selection, and 13 machine-learning algorithms were compared. SMOTETomek was used during model development to address class imbalance. Performance was evaluated using stratified five-fold cross-validation and a held-out internal test set. SHapley Additive exPlanations (SHAP) were used to interpret model predictions. RESULTS: LASSO retained eight predictors: waist circumference, body fat percentage (FAT%), weight, age, moderate physical activity (MPA), vigorous physical activity, sleep duration, and sex. Extra Trees achieved the best cross-validation performance, with a mean AUC of 0.749 (SD, 0.043) and an F1 score of 0.798 (SD, 0.028). Its relative advantage may reflect the ability of randomized tree ensembles to capture nonlinear relationships and feature interactions while reducing variance through aggregation. In the held-out internal test set, the model achieved an AUC of 0.864, accuracy of 92.02%, specificity of 93.33%, and sensitivity of 76.92%. The lower sensitivity relative to accuracy and specificity indicates that some adolescents with MS may remain undetected. SHAP ranked FAT% as the most influential predictor (mean absolute SHAP value, 0.08) and MPA as the leading movement-behavior predictor (0.04), thereby improving the transparency of model predictions. CONCLUSIONS: The Extra Trees model showed moderate cross-validation discrimination and stronger performance in the internal test set, although this difference warrants cautious interpretation. SHAP improved model transparency by identifying FAT% and MPA as influential predictors. Multicenter external validation and feasibility assessment are required before large-scale screening. CI - Copyright (c) 2026 Cao, Feng, Wang and Wang. FAU - Cao, Liquan AU - Cao L AD - Tianjin University of Sport, Tianjin, China. AD - Tianjin Key Laboratory of Sports and Health Integration and Health Promotion, Tianjin, China. FAU - Feng, Zhanpeng AU - Feng Z AD - Tianjin University of Sport, Tianjin, China. AD - Tianjin Key Laboratory of Sports and Health Integration and Health Promotion, Tianjin, China. FAU - Wang, Jing AU - Wang J AD - Tianjin University of Sport, Tianjin, China. FAU - Wang, Yun AU - Wang Y AD - Tianjin University of Sport, Tianjin, China. LA - eng PT - Journal Article DEP - 20260917 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Metabolic Syndrome/diagnosis MH - Adolescent MH - *Machine Learning MH - Cross-Sectional Studies MH - Female MH - Male MH - China MH - Predictive Learning Models MH - Child MH - *Exercise/physiology MH - Accelerometry MH - Absorptiometry, Photon MH - Prediction Algorithms PMC - PMC13627327 OTO - NOTNLM OT - 24-hour movement behaviors OT - SHAP OT - adolescent OT - machine learning OT - metabolic syndrome COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/02 13:37 MHDA- 2026/10/02 13:38 PMCR- 2026/09/17 CRDT- 2026/10/02 05:59 PHST- 2026/07/05 00:00 [received] PHST- 2026/08/23 00:00 [revised] PHST- 2026/08/30 00:00 [accepted] PHST- 2026/10/02 13:38 [medline] PHST- 2026/10/02 13:37 [pubmed] PHST- 2026/10/02 05:59 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1928562 [doi] PST - epublish SO - Front Public Health. 2026 Sep 17;14:1928562. doi: 10.3389/fpubh.2026.1928562. eCollection 2026. PMID- 42824137 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261003 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Mediating role of peripheral thyroid hormone conversion efficiency in the association between BMI and IGF-1 in children with growth retardation: a cross-sectional study. PG - 1941425 LID - 10.3389/fendo.2026.1941425 [doi] LID - 1941425 AB - OBJECTIVE: To examine the association between body mass index (BMI) standard deviation score (SDS) and insulin-like growth factor-1 (IGF-1) SDS and whether thyroid hormones mediate it, focusing on the peripheral conversion marker free triiodothyronine/free thyroxine (FT3/FT4) ratio, in prepubertal children (2.0-9.0 years) with height SDS < -1.0. METHODS: This retrospective cross-sectional study included 1,242 such children. Restricted cubic splines assessed the BMI-IGF-1 relationship, and Bootstrap mediation (5,000 resamples) tested indirect effects of FT3/FT4, FT3, FT4, and thyroid-stimulating hormone (TSH), adjusted for sex, age and height SDS. Reverse mediation, subgroup, interaction, Monte Carlo power, and E-value sensitivity analyses were also performed. RESULTS: A significant linear positive association was found (P-overall < 0.001; P-nonlinear = 0.0719). FT3/FT4 and FT3 showed significant partial mediation, accounting for 9.12% (P < 0.001) and 11.60% (P = 0.0108) of the total effect, respectively; TSH and FT4 did not. Sensitivity analyses confirmed robustness after stricter prepubertal cutoffs and exclusion of overweight/obese children. Notably, only FT3/FT4 remained significant after excluding suspected Growth Hormone Deficiency (GHD) (IGF-1 SDS < -2.0). The FT3/FT4 ratio remained a significant mediator across all subgroup analyses. Reverse mediation analysis yielded a substantially smaller indirect effect in the reverse direction. E-values for FT3/FT4 and FT3 were 1.0764 and 1.0609, respectively. CONCLUSION: In this growth-retarded prepubertal cohort, BMI and IGF-1 are linearly associated. The FT3/FT4 ratio is statistically supported as a partial mediator with moderate effect size but strong statistical robustness, while the central TSH pathway is uninvolved, supporting a peripheral "thrifty" regulatory strategy and offering a potential target for nutritional intervention. These mediation findings reflect statistical associations and require prospective validation. CI - Copyright (c) 2026 Zhang and Liu. FAU - Zhang, Mengying AU - Zhang M AD - Department of Child Health Care; Clinical Research Center of Child Health Care and Developmental & Behavioral Disorders, Institute of Maternal and Child Health, Wuhan Children's Hospital (Wuhan Maternal and Child Health Care Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China. FAU - Liu, Hua AU - Liu H AD - Department of Child Health Care; Clinical Research Center of Child Health Care and Developmental & Behavioral Disorders, Institute of Maternal and Child Health, Wuhan Children's Hospital (Wuhan Maternal and Child Health Care Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China. LA - eng PT - Journal Article DEP - 20260917 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 67763-96-6 (Insulin-Like Growth Factor I) RN - 0 (Thyroid Hormones) RN - 0 (IGF1 protein, human) RN - Q51BO43MG4 (Thyroxine) RN - 06LU7C9H1V (Triiodothyronine) SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Insulin-Like Growth Factor I/metabolism/analysis MH - Female MH - *Body Mass Index MH - Child MH - Retrospective Studies MH - Child, Preschool MH - Male MH - *Growth Disorders/blood/metabolism MH - *Thyroid Hormones/blood/metabolism MH - Thyroxine/blood MH - *Triiodothyronine/blood PMC - PMC13627020 OTO - NOTNLM OT - FT3/FT4 ratio OT - body mass index OT - growth retardation OT - insulin-like growth factor-1 OT - mediation analysis OT - prepubertal children COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/02 13:37 MHDA- 2026/10/02 13:38 PMCR- 2026/09/17 CRDT- 2026/10/02 05:30 PHST- 2026/07/18 00:00 [received] PHST- 2026/08/31 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/02 13:38 [medline] PHST- 2026/10/02 13:37 [pubmed] PHST- 2026/10/02 05:30 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - 10.3389/fendo.2026.1941425 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Sep 17;17:1941425. doi: 10.3389/fendo.2026.1941425. eCollection 2026. PMID- 42823676 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261003 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Aug 13 TI - Artificial intelligence attitudes in relation to Mediterranean diet adherence and environmental footprints: a cross-sectional study. LID - 10.1186/s12889-026-28997-4 [doi] LID - 2730 AB - OBJECTIVE: This study aimed to evaluate the relationship between attitudes towards artificial intelligence and adherence to the Mediterranean Diet (MD), carbon footprint awareness and environmental footprint awareness among adults. METHODS: This cross-sectional study was conducted in Ankara, Turkey, using snowball sampling and an online questionnaire. The study included 1350 adults aged 18-65 years. Data were collected through a questionnaire containing demographic information, self-report anthropometric measurements, and validated scales. Artificial Intelligence Attitude Scale, Ecological Footprint Awareness Scale, Carbon Footprint Awareness Scale, and Mediterranean Diet Adherence Scale (MEDAS) were used in the study. RESULTS: Of the participants, 76.7% were female and 23.3% were male. Participants with adequate MD adherence (MEDAS >/= 7) were older, had higher BMI, and demonstrated higher ecological and carbon footprint awareness than those with lower adherence. AIAS-4 scores were similar between the MD adherence groups despite a weak negative correlation between AI attitudes and MEDAS scores (rho = -0.057, p = 0.037). AI attitudes were positively correlated with ecological (rho = 0.091, p < 0.001) and carbon footprint awareness (rho= 0.058, p = 0.032). In the multivariable linear regression model, ecological footprint awareness was independently associated with age (B = 0.229, p < 0.001), AIAS-4 (B = 1.151, p < 0.001), carbon footprint awareness (B = 1.331, p < 0.001), and male gender (B = - 4.186, p = 0.002), whereas MD adherence, education level, and AI use frequency were not significant predictors. The model explained 31.0% of the variance in ecological footprint awareness (R(2) = 0.310, p < 0.001). CONCLUSIONS: Positive attitudes toward artificial intelligence were associated with greater ecological and carbon footprint awareness but with slightly lower adherence to the Mediterranean diet. In contrast, greater adherence to the Mediterranean diet was positively associated with environmental footprint awareness. Carbon footprint awareness emerged as the strongest independent predictor of ecological footprint awareness. These findings provide preliminary evidence that attitudes toward artificial intelligence, dietary behavior, and environmental sustainability awareness are interrelated, although the observed associations were generally small and should be interpreted cautiously. CI - (c) 2026. The Author(s). FAU - Arslan, Neslihan AU - Arslan N AUID- ORCID: 0000-0002-1232-8009 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Faculty, University of Health Sciences, Ankara, Turkey. akdeniz.neslihan91@gmail.com. FAU - Celik, Ozge Mengi AU - Celik OM AUID- ORCID: 0000-0002-0298-9591 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Faculty, University of Health Sciences, Ankara, Turkey. FAU - Guler, Ummugulsum AU - Guler U AUID- ORCID: 0009-0001-3352-6047 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkey. FAU - Ekici, Emine Merve AU - Ekici EM AUID- ORCID: 0000-0001-5409-6309 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Faculty, University of Health Sciences, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20260813 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Male MH - Cross-Sectional Studies MH - Middle Aged MH - Female MH - *Diet, Mediterranean/statistics & numerical data/psychology MH - Adult MH - *Artificial Intelligence MH - Turkey MH - Adolescent MH - Aged MH - Young Adult MH - *Carbon Footprint/statistics & numerical data MH - Surveys and Questionnaires MH - *Patient Compliance/statistics & numerical data/psychology PMC - PMC13628745 OTO - NOTNLM OT - Artificial intelligence OT - Carbon footprint OT - Ecological footprint OT - Mediterranean diet COIS- Declarations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was conducted with the approval of the University of Health Sciences Gulhane Scientific Research Ethics Committee, numbered 2025/357. Informed consent was obtained from all participants included in the study EDAT- 2026/10/02 05:31 MHDA- 2026/10/02 05:32 PMCR- 2026/08/13 CRDT- 2026/10/02 00:38 PHST- 2026/04/13 00:00 [received] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/10/02 05:32 [medline] PHST- 2026/10/02 05:31 [pubmed] PHST- 2026/10/02 00:38 [entrez] PHST- 2026/08/13 00:00 [pmc-release] AID - 10.1186/s12889-026-28997-4 [pii] AID - 28997 [pii] AID - 10.1186/s12889-026-28997-4 [doi] PST - epublish SO - BMC Public Health. 2026 Aug 13;26(1):2730. doi: 10.1186/s12889-026-28997-4. PMID- 42819986 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261001 LR - 20261001 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - The "pro-inflammatory imprint" of ultra-processed food exposure: a review of mechanisms affecting child and adolescent health and development via the gut microbiome-inflammation axis. PG - 1843587 LID - 10.3389/fnut.2026.1843587 [doi] LID - 1843587 AB - The prevalence of ultra-processed food (UPF) consumption in pediatric diets has raised significant concerns regarding long-term health. This review examines evidence for a proposed 'pro-inflammatory imprint' involving the gut microbiome-inflammation axis. Using a structured narrative synthesis of pediatric observational evidence, adult intervention studies, preclinical research, multi-omics data, and public health evaluations, we examine associations between UPF exposure and metabolic, inflammatory, cognitive, and neurodevelopmental outcomes while distinguishing direct from indirect evidence. We propose the Pediatric-Specific Integrated Dietary Inflammatory Index (cP-IDII) as an unvalidated, hypothesis-generating research framework for integrating reproducible nutrient- and processing-related dietary exposures; downstream microbial, intestinal-barrier, inflammatory, metabolic, and immune measures are reserved for external validation. Furthermore, we discuss the role of commercial determinants and environmental factors in shaping child health. The synthesis identifies measurement gaps and complementary policy entry points across product composition, food environments, affordability, and marketing. Empirical development and external validation are required before the cP-IDII can be used for clinical, epidemiological, or public health decision-making. CI - Copyright (c) 2026 Liu, Luo, Yan, Yang, Long, Yang, He and Tao. FAU - Liu, Qinghua AU - Liu Q AD - College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China. FAU - Luo, Lijiao AU - Luo L AD - College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China. FAU - Yan, Zhiwen AU - Yan Z AD - Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Yang, Pan AU - Yang P AD - Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Long, Teng AU - Long T AD - Department of Clinical Nutrition, People's Hospital of Chongqing, Hechuan, Chongqing, China. FAU - Yang, Yuntao AU - Yang Y AD - Department of Clinical Nutrition, People's Hospital of Chongqing, Hechuan, Chongqing, China. FAU - He, Min AU - He M AD - Department of Clinical Nutrition, People's Hospital of Chongqing, Hechuan, Chongqing, China. FAU - Tao, Li AU - Tao L AD - Department of Clinical Nutrition, People's Hospital of Chongqing, Hechuan, Chongqing, China. LA - eng PT - Journal Article PT - Review DEP - 20260916 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13625691 OTO - NOTNLM OT - Dietary Inflammatory Index (DII) OT - childhood obesity OT - food environment OT - gut-brain axis OT - metabolic programming OT - neurodevelopment OT - ultra-processed foods COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/02 03:09 MHDA- 2026/10/02 03:10 PMCR- 2026/09/16 CRDT- 2026/10/01 17:31 PHST- 2026/03/31 00:00 [received] PHST- 2026/07/29 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/02 03:10 [medline] PHST- 2026/10/02 03:09 [pubmed] PHST- 2026/10/01 17:31 [entrez] PHST- 2026/09/16 00:00 [pmc-release] AID - 10.3389/fnut.2026.1843587 [doi] PST - epublish SO - Front Nutr. 2026 Sep 16;13:1843587. doi: 10.3389/fnut.2026.1843587. eCollection 2026. PMID- 42818738 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261001 LR - 20261002 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Body roundness index and adolescent metabolic syndrome: dose-response analysis and serum biomarker mediation. PG - 1930822 LID - 10.3389/fnut.2026.1930822 [doi] LID - 1930822 AB - BACKGROUND: The Body Roundness Index (BRI) combines waist circumference and height into a single geometric measure that is intended to reflect visceral adiposity. Its ability to predict metabolic syndrome (MetS) in adolescents and the biological processes that mediate this association have not been well defined. We tested the BRI-MetS relationship in Chinese adolescents, compared BRI with body mass index (BMI), and examined whether circulating biomarkers mediated this association. METHODS: This cross-sectional study recruited 914 Chinese adolescents (53.2% boys) aged 11-16 years. MetS was defined according to Chinese pediatric guidelines (CN2025) and the International Diabetes Federation (IDF) criteria. Associations and predictive performance were assessed using logistic regression, restricted cubic splines (RCS), and receiver operating characteristic (ROC) curves. Subgroup analyses were stratified by sex and BMI category. Potential mechanistic pathways involving 22 serum biomarkers were investigated by correlation networks, hierarchical clustering, and two-stage mediation models. RESULTS: BRI was positively associated with MetS (CN2025: OR = 3.63 per unit, 95%CI 2.91-4.53; IDF: OR = 2.64, 95%CI 2.14-3.26). RCS demonstrated non-linear dose-response relationship, with an acceleration in risk beyond BRI of approximately 4.0. BRI outperformed BMI in discriminating MetS (AUC 0.873 vs. 0.835, p = 0.005), especially among normal-weight participants (OR = 3.48, p < 0.001). Sex stratification showed that BRI was associated with hypertriglyceridemia and hypertension in male adolescents (p < 0.001) but not in female adolescents. We identified three biomarker co-expression modules: the upward module (ALT, FINS, and UA) mediated 52.9% of the association between BRI and hypertriglyceridemia and 54.1-59.5% of the association between BRI and hypertension; SFRP5 and irisin mediated the associations of BRI with fasting plasma glucose (FPG) and HDL-cholesterol, respectively. CONCLUSION: BRI may be a better predictor of MetS in Chinese adolescents, particularly when MetS is defined using domestic criteria. Its predictive power was greatest among normal-weight adolescents and varied by sex. Exploratory mediation analyses identified the metabolic-inflammatory axis and protective adipokines as key mediators, suggesting hypothesis-generating targets for interventions to improve adolescent metabolic health that require longitudinal validation. CI - Copyright (c) 2026 Yao, Wang, Zhou, Wang, Wang and Du. FAU - Yao, Hui AU - Yao H AD - Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Wang, Yiwen AU - Wang Y AD - Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Zhou, Fang AU - Zhou F AD - Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Wang, Fei AU - Wang F AD - Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Wang, Xiaochen AU - Wang X AD - Department of Endocrinology, Liaoning Provincial People's Hospital, Shenyang, China. FAU - Du, Runyu AU - Du R AD - Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China. LA - eng PT - Journal Article DEP - 20260916 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13623853 OTO - NOTNLM OT - adipokine OT - adolescent OT - body roundness index OT - dose-response analysis OT - mediation analysis OT - metabolic syndrome OT - restricted cubic spline COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/01 11:37 MHDA- 2026/10/01 11:38 PMCR- 2026/09/16 CRDT- 2026/10/01 10:15 PHST- 2026/07/07 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/08/30 00:00 [accepted] PHST- 2026/10/01 11:38 [medline] PHST- 2026/10/01 11:37 [pubmed] PHST- 2026/10/01 10:15 [entrez] PHST- 2026/09/16 00:00 [pmc-release] AID - 10.3389/fnut.2026.1930822 [doi] PST - epublish SO - Front Nutr. 2026 Sep 16;13:1930822. doi: 10.3389/fnut.2026.1930822. eCollection 2026. PMID- 42815717 OWN - NLM STAT- Publisher LR - 20261027 IS - 2352-3840 (Electronic) IS - 1499-2671 (Linking) DP - 2026 Sep 30 TI - Comparing Physical Activity and Sedentary Time in Children and Adolescents With Type 1 Diabetes Using Different Accelerometer Data Processing Protocols. LID - S1499-2671(26)00368-0 [pii] LID - 10.1016/j.jcjd.2026.09.005 [doi] AB - OBJECTIVE: Regular physical activity (PA) is crucial for managing type 1 diabetes (T1D), yet many children fail to achieve the recommended 60 min of daily moderate-to-vigorous PA (MVPA). Device-based (accelerometry) measurement of PA and sedentary time (SED) may be influenced by analytical decisions (e.g. cut points), but less is known about these methodological effects in children with T1D. This study aims to 1) compare the effects of different accelerometer data processing protocols on PA and SED estimates and 2) evaluate how these variations influence the proportion of children with T1D meeting PA guidelines. METHODS: Participants aged 7 to 17 years with T1D (n=43; 49% female; 13.7+/-2.3 years) wore an ActiGraph accelerometer on their right hip for 7 days. ActiLife software processed data according to 8 published protocols to classify SED, light PA (LPA), and MVPA. Linear mixed-effects models compared activity time estimates across protocols, and Cochran's Q test assessed differences in the proportion meeting PA guidelines. RESULTS: SED, LPA, and MVPA estimates differed significantly across protocols (p<0.001), with mean daily SED ranging from 438 to 700 min, LPA from 82 to 329 min, and MVPA from 16 to 193 min. Protocol choice also influenced the proportion of participants meeting the MVPA guidelines (Q(7)=172.0, n=31, p<0.001), with some methods consistently classifying more participants as meeting recommendations than others. CONCLUSIONS: This study addresses gaps in accelerometer-based research by identifying protocol-specific variability in activity measurement in children with T1D. Without criterion reference measures, it remains unclear which protocols provide the most accurate estimates. Future research should incorporate validation methods to strengthen methodological decision-making. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Sedarous, Eden AU - Sedarous E AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. FAU - Letts, Elyse AU - Letts E AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. FAU - Byra, Madelyn M AU - Byra MM AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. FAU - Ball, Elizabeth AU - Ball E AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. FAU - McAssey, Karen AU - McAssey K AD - Department of Pediatrics, McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada. FAU - Timmons, Brian W AU - Timmons BW AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada. FAU - Obeid, Joyce AU - Obeid J AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada. Electronic address: obeidj@mcmaster.ca. LA - eng PT - Journal Article DEP - 20260930 PL - Canada TA - Can J Diabetes JT - Canadian journal of diabetes JID - 101148810 SB - IM OTO - NOTNLM OT - cut point OT - device-based measurement OT - moderate-to-vigorous physical activity OT - pediatric chronic disease OT - wear-time validation EDAT- 2026/09/30 23:30 MHDA- 2026/09/30 23:30 CRDT- 2026/09/30 19:32 PHST- 2026/05/20 00:00 [received] PHST- 2026/08/14 00:00 [revised] PHST- 2026/09/14 00:00 [accepted] PHST- 2026/09/30 23:30 [pubmed] PHST- 2026/09/30 23:30 [medline] PHST- 2026/09/30 19:32 [entrez] AID - S1499-2671(26)00368-0 [pii] AID - 10.1016/j.jcjd.2026.09.005 [doi] PST - aheadofprint SO - Can J Diabetes. 2026 Sep 30:S1499-2671(26)00368-0. doi: 10.1016/j.jcjd.2026.09.005. PMID- 42814674 OWN - NLM STAT- In-Process LR - 20260930 IS - 1423-0143 (Electronic) IS - 1420-4096 (Linking) VI - 51 IP - 1 DP - 2026 TI - Erratum. PG - 915-922 LID - 10.1159/kbr/adjag008 [doi] AB - In the article "Lipids and Lipid Metabolites in the Diagnosis, Risk Prediction, and Treatment of Chronic Kidney Disease and Acute Kidney Injury: A Narrative Review" [Kidney Blood Press Res. 2026;51:567-588. https://doi.org/10.1159/000552568] by Erfurt et al. Table 1 was incorrectly transferred during the production process. A corrected version of Table 1 is available below.Table 1.Summaries of all studies discussed, including design and outcomesReferenceDesignMethodologyMain findingsConclusionDiagnostic and prognostic role of fatty acids and their metabolites in CKDShearer et al. [36] (2012)Comparison of plasma fatty acid (FA) profiles in patients with stage 3-4 CKD (n = 10), stage 5 CKD near dialysis initiation (n = 20; one excluded for poor FA recovery), and 10 non-CKD controls from Karolinska prospective cohorts (mean follow-up for stage 5 = 2.7+/-1.7 years)FAs measured by gas chromatography; eGFR (MDRD) and FA relationships assessed using Deming orthogonal regression and Cox models (age-adjusted)Stage 5 CKD patients had lower relative abundances of polyunsaturated Fas - especially arachidonate synthesis intermediates - and lower stearic acid; EPA was lower in stage 5 vs. stage 3-4 and controls. Monounsaturated FAs showed opposing trends with declining eGFR (palmitate decreased, oleic acid increased). Nervonic acid abundance was a strong age-adjusted predictor of mortality in dialysis patientsMetabolic intermediates of arachidonic acid synthesis are reduced in CKDNervonic acid significantly predicts all-cause mortalityAfshinnia et al. [39] (2016)Nested case-control study used fasting serum from a subcohort of the CRIC cohort to identify lipidomic predictors of progression to end-stage kidney disease (ESKD)LC-MS shotgun lipidomics510 lipids detected (382 after filtering); 49 showed nominal differences between progressors and nonprogressors. Statistical selection combined t tests with FDR correction, PLS-DA, and Random Forest, and candidates were tested in logistic regression models adjusted for eGFR, UPCR, demographics, diabetes, hypertension, and heart failure. Two diacylglycerols (DAG 36:0 and DAG 32:0) were lower in progressors and each 1-SD higher level was associated with substantially reduced progression risk; monoacylglycerol MAG 16:0 was higher in progressors and associated with increased risk. Class-level findings showed enrichment and differential regulation of cholesterol esters, DAGs, and phosphatidylethanolamines, with chain length and unsaturation patterns differing between groupsMultimarker lipid panels significantly improve discrimination vs. a base model (eGFR + UPCR)Gollasch et al. [37] (2020)Comparison of fatty acid profiles in 15 healthy volunteers and 15 end-stage kidney disease (ESKD) patients on maintenance hemodialysis (HD)Venous blood collected from controls and pre-/post-HD from patients; RBC and plasma fatty acids measured by HPLC-MSESRD patients showed altered RBC and plasma fatty acid patterns: reduced EPA (C20:5 n-3) and certain n-6 species and increased very-long-chain monounsaturated fatty acids (e.g., C24:1 n-9); most free fatty acids were higher in plasma and RBCs of patients. A single HD session produced only minor changes in several total plasma saturated and n-6 fatty acids and did not meaningfully change RBC fatty acid composition or the RBC omega-3 indexTotal fatty acid levels differed significantly in RBCs from healthy controls and CKD patients, hemodialysis has no effect on plasma or RBC fatty acid levelsSikorska-Wisniewska et al. [38] (2020)Cohort (n = 134) of 3 groups: patients after renal transplantation (RTx group, n = 24), patients with CKD in stages 2-5, not on dialysis (CKD-ND group, n = 67), and controls without CKD (n = 43)Fatty acids (FA) assessed by gas chromatography-mass spectrometry; same FA analysed in samples of adipose tissue taken during the kidney transplantation procedure and compared with FA of controlsSerum omega-3 and omega-6 PUFA levels were highest in controls and lowest in RTx patients. No associations were found between GFR and FA levels. Fish intake correlated with EPA/DHA levels in some groups, but ALA intake did not correlate with serum ALA; EPA, DHA, LA, and AA generally correlated inversely with triglycerides (some correlations reached significance), while no meaningful links were found with CRP, albumin, BMI, or adipose tissue PUFA compositionRTx patients present significantly lower serum content of all the examined PUFAs, in comparison to the CKD-ND group and controlsLanzon et al. [47] (2021)Comparison of 11 severely obese patients with chronic kidney disease (OD) and 14 obese controls without CKD (O)Serum lipidomics (LC-MS) and polar metabolomics (GC-HRAM-MS)Lipidomics: 71 serum lipids differed (most increased in OD), notably rises in TGs (many unsaturated, short-/medium-chain), diglycerides (DGs), phosphatidylcholines (PCs), lysophosphatidylcholines (LysoPCs) and plasmalogens, while sphingomyelins (SMs) and phosphatidylinositols (PIs) decreased. Short-chain TGs correlated negatively with eGFR in OD; many lipids correlated with glucose in O but not in OD. Metabolomics: several essential and conditionally essential amino acids (e.g., isoleucine, lysine, proline) were higher in OD. After bariatric surgery OD patients showed lipidomic shifts toward profiles closer to O; DGs and medium-chain TGs correlated with uric acid post-surgery. Serum levels of several essential amino acids (isoleucine, lysine, threonine, valine) and some conditional amino acids fell after surgery; urine valine and glutamine decreased while hippuric acid increasedResults justify the use of lipidomics to validate possible early markers of risk of CKD in patients with severe obesityMika et al. [40] (2021)Study of 198 kidney transplant (Tx) patients (age 18-70) and 48 matched controlsAnalysis of fasting plasma fatty acid (FA) profiles by GC-MS after Folch extractionTx patients - treated with standard triple immunosuppression and excluding FA supplement users - showed distinct FA alterations vs. controls: lower long- and very-long-chain saturated and polyunsaturated FAs (many n-3/n-6 PUFA and branched-chain FAs), but higher palmitic (16:0) and certain monounsaturated FAs (16:1, 18:1). Disturbances were greatest within the first month post-transplant (Tx1M) and partially normalized by >12 months, though differences from controls persisted. PCA and hierarchical clustering clearly separated Tx and control groups. Comorbidities and clinical factors affected profilesFA profiles are significantly different between patients and controls, tendency for normalization in long-term kidney recipients, n-3 PUFA strong inverse associated with inflammationPinto et al. [41] (2021)Investigation of relationships between dialysis, sleep and 24 h heart rate variability (HRV) and LC n-3 PUFA status in hemodialysis patients (CKD stage 5) (n = 45)Pre-dialysis blood samples, measurement of erythrocyte and plasma fatty acid compositionCompared with controls, patients had higher heart rates, lower HRV, more inflammation, and lower LC n-3 PUFA levels; erythrocyte omega-3 index was low overall. While no consistent associations were found for erythrocyte O3I, EPA, or DHA with HRV, plasma DHA correlated positively with HRV during dialysis, plasma EPA with 24-h HRV, and EPA:DHA ratio, DPA(n-3), and EPA showed mixed inverse or negative associations with short-term HRV, indicating a complex relationshipImpaired EPA metabolism might contribute to sudden cardiac death (SCD) risk increase in dialysis patientsSledzinski et al. [42] (2022)Study of 35 CKD patients (19 men, 16 women; age 22-70) comparison of serum fatty acid (FA) profiles before and 3 months after deceased-donor kidney transplantationCollection of fasting serum, lipids extracted and converted to FAMEs, subsequently analyzed by GC-EI-MSTotal even-chain saturated FAs, odd- and branched-chain FAs, and total SFAs did not change, but specific FAs shifted: decreases in some 12-, 18-, and 26-carbon FAs, a rise in palmitic acid (16:0), and a significant reduction in ultra-long-chain FAs (>/=26C), especially 26:0. Total MUFAs were unchanged though 20:1 increased and the 18:1/18:0 desaturation index rose. Among PUFAs, total n-6 was stable despite decreases in DGLA (20:3n-6), ARA, and AdA (22:4n-6) while 18:2n-6 increased; total n-3 PUFAs declinedSignificant reduction in n-3 PUFAs in renal transplant recipients 3 months after transplantation, which may contribute to increased cardiovascular riskSledzinski et al. [45] (2024)Prospective study of 25 CKD patients (23 deceased-donor, 2 living-donor)Quantification of serum fatty acid (FA) profiles before kidney transplantation (KTx), 3 months after, and 6-12 months after. Samples analyzed by GC-MSTotal saturated FAs were largely unchanged except for an increase in odd-chain SFAs; very-long-chain FAs (>20C) rose by 6-12 months, whereas ultra-long-chain FAs (>/=26C) fell progressively. Total MUFAs were stable overall, but C20:1, C22:1, C24:1 increased and C18:1 trended down. Total n-3 PUFAs (including DHA) and some n-6 PUFAs (ARA, DGLA) decreased at 3 months then increased by 6-12 months; linoleic acid rose at 3 monthsFA dynamics following KTx are complex and may indicate a need for supplementationMantovani et al. [46] (2023)Follow-up of 85 post-menopausal women with non-insulin-treated T2DM and preserved kidney function at baselineSerum NEFA concentrations measured using enzymatic colorimetric method, eGFR was estimatedHigher baseline NEFA levels strongly predicted kidney function decline. Patients in the highest NEFA tertile had significantly greater risk by Kaplan-Meier analysisHigher circulating levels of NEFA strongly associated with faster kidney function declineOng et al. [43] (2023)Pooled analysis by the Fatty Acids and Outcomes Research Consortium, combination of de novo data from 19 prospective cohorts (25,570 participants without baseline CKD; median follow-up 11.3 years) to examine circulating/adipose n-3 PUFA biomarkers and risk of incident chronic kidney disease (CKD)Biomarkers (ALA, EPA, DPA, DHA) were measured by gas chromatography in various lipid compartments, and incident CKD was defined as follow-up eGFR <60 mL/min/1.73 m2 among those with baseline eGFR >/=60See "Conclusion"Meta-analyses (adjusted Cox/Poisson and linear models) showed higher seafood-derived n-3 PUFAs (EPA/DPA/DHA) were associated with lower risk of incident CKD (8% lower per interquintile range; highest vs. lowest quintile RR 0.87) and with slower annual eGFR decline; results were consistent across compartments and sensitivity analyses. ALA showed no association with incident CKD or eGFR decline. Associations were not modified by age, race, hypertension, diabetes, coronary disease, or baseline eGFRKoh et al., 2024 [44]Prospective observational cohort study, 73.419 participants without CKD and 6. 735 with CKDAnalysis of systemic PUFA levelsHigher PUFA levels - especially omega-3s like DHA - were linked to lower risk of developing CKD and reduced all-cause mortality; higher PUFA levels also correlated with younger age, female sex, nonwhite race, nonsmoking, and healthier clinical profilesAmong participants without CKD, higher plasma levels of total PUFAs are associated with a lower risk of developing CKDFatty acids, their metabolites and modulators of fatty acid metabolism in CKD managementBarden et al. [55] (2015)Double-blinded, placebo-controlled intervention, CKD patients randomized to n-3 fatty acids, CoQ, both or control, daily for 8 weeksExamination of n-3 fatty acid effects on plasma and urinary 20-HETE, plasma and urinary F2-isoprostanes, changes in blood pressureTreatment raised platelet n-3 and plasma CoQ (confirming compliance) and significantly lowered plasma 20-HETE and F2-isoprostanes (urinary levels unchanged) and reduced systolic and diastolic BP during both awake and asleep periods. Post-intervention 20-HETE was positively associated with 24-h SBP and DBP (driven by daytime BP)Identification of a plausible mechanism underlying the reduction in blood pressure observed in patients with chronic kidney disease after omega-3 fatty acid supplementationHu et al. [56] (2017)Review and meta-analysis: 9 RCT with CKD patients includedEvaluation of the benefits and risks of omega-3 fatty acid supplementationSee "Conclusion"Omega-3 supplementation significantly reduces proteinuria and lowers risk of ESKD but does not significantly affect creatinine clearance rate or eGFR. Subgroup analysis shows location, age, and study quality influences the proteinuria benefitDe Boer et al. [57] (2019)RCT: 1,312 adults with type 2 diabetesRandomization to receive vitamin D3 and omega-3 fatty acids and placebo for 5 years, primary outcome: GFR changeNo significant differences in eGFR, urine ACR, or a composite of kidney failure/death between supplement and placebo groups. Adverse events similar across groupsResults do not support use of vitamin D or omega-3 fatty acid supplementationValle Flores et al. [58] (2020)Prospective, randomized, double-blind study in CKD patients undergoing hemodialysisTwo groups: group A (46 patients) received omega-3 fatty acids during 12-week, control group (group B, 47 patients) received paraffin oil, general characteristics, analysis of nutritional indicators, renal disease markers and CRP, IL-6, IL-10, and TNF-alpha evaluatedOmega-3 supplementation produced significant reductions in inflammatory markers and significantly raised the IL-10/IL-6 ratio, while IL-10 increased nonsignificantly; no meaningful changes in the control groupOral omega-3 fatty acid supplementation significantly reduces inflammatory marker concentrations in patients with chronic kidney disease undergoing hemodialysisBunout et al. [59] (2021)RCT: 100 CKD patients supplemented for 3 months with docosahexaenoic and eicosapentaenoic acids or a corn oil supplementEvaluation at baseline, 6 weeks, 12 weeks; variables: blood and morning spot urine samples, blood pressure, carotid intima media thickness, and pulse wave velocity, main outcome: reduction of >/=20% in urine albuminThe n-3 PUFA group showed significant rises in EPA/DHA and omega-3 index and a drop in triglycerides, while both groups had reductions in urine albumin excretion (no significant between-group difference). Pulse wave velocity remained stable with n-3 PUFA but increased in controls; HbA1c rose in both groups and inflammatory markers were unchanged. Secondary analysis revealed systolic blood pressure fall in n-3 PUFA usersOmega-3 fatty acid supplement does not modify urine albumin excretion in patients with CKD but improves pulse wave velocity and serum triglyceride levelsLin et al. [60] (2022)Investigation of oral supplementation with omega-3 PUFA on circulating IL-6, cardiometabolic parameters, skin moisturization, and symptoms of pruritus in hemodialysis patientsTwenty-seven subjects consumed fish oil daily for 3 months and were measured at baseline, first, second, and third month post-supplementationFish oil did not change BMI, serum calcium, phosphorus, or iPTH but significantly reduced pruritus and improved skin hydration. Inflammatory markers (CRP, IL-6), plasma creatinine, and several lipid measures (total cholesterol down, HDL up, TG improved; LDL fell then rose slightly by month three) also improvedOmega-3 PUFA beneficial in hemodialysisAo et al. [61] (2024)24,497 patients with diabetes includedCox proportional hazards regression models used to estimate hazard ratios for CKD risk and impact of fish oilAdjusted analyses found lower CKD risk in diabetic patients who used fish oil and an approximate 2.79-year delay in CKD onset, with stronger effects in men, older adults, non-smokers, and those with healthier diets. Fish oil use also associated with lower HbA1c and CRP and higher HDLFish oil might reduce CKD risk in diabeticsFei et al. [62] (2024)Review and meta-analysis: 9 studies, total of 347 proteinuric participants included in the analysisAnalysis of the impact of omega-3 fatty acid supplementation on proteinuriaSee "Conclusion"Pooled results using fixed- and random-effects models showed non-significant standardized mean differences, with substantial heterogeneity. Study quality was moderate (JADAD 2-4); funnel plot showed no clear publication bias but power was limited by few studies. Overall, omega-3s did not demonstrate a significant anti-proteinuric benefit, though heterogeneity limits confidenceLok et al. [63] (2026)Double-blinded randomized trial of 1,228 adults on maintenance hemodialysisDaily fish-oil supplementation (4 g n-3 fatty acids: 1.6 g EPA + 0.8 g DHA) in comparison with corn-oil placebo over 3.5 yearsFish-oil significantly reduced the rate of serious cardiovascular events (primary end point) vs. placebo and lowered risks of cardiac death, myocardial infarction, stroke, and amputations, with similar adherence and adverse events between groupsFish-oil reduces cardiovascular and mortality risk in hemodialysis patientsDiagnostic and prognostic role of fatty acids and their metabolites in AKIWang et al. [50] (2020)Prospective pilot study: pediatric intensive care, 101 sepsis patients, 30 healthy controlsSerum ApoA5 levels were determined by ELISAApoA5 was lower in septic children than healthy controls and significantly lower in nonsurvivors vs. survivors, correlating with MODS and AKI; low ApoA5 was an independent risk factor for PICU mortality. ROC analysis showed ApoA5 had diagnostic and prognostic value, and it correlated positively with serum calciumLower serum ApoA5 level predicts sepsis-associated complications, e.g., AKI, or MODS in childrenSun et al. [51] (2021)Pilot study: 17 patients with new diagnosed AKI and 17 healthy controlsSerum metabolomic profilingFrom thousands of ion features, 51 reliable metabolites were examined; 1-arachidonoyl-lysoPC was prominent on day 1, while creatine, citrulline, and others distinguished survivors from non-survivors at day 8, with higher levels in those who died. Multimetabolite ROC models predicted outcomes: a 4-metabolite (m4) day-1 model performed best for mortality, an 11-metabolite (m11) day-8 model showed high specificity, and a 3-metabolite (m3) model predicted KRT independence with a favorable AUCDistinct metabolite panels enable assessment of mortality risk in acute kidney injury (AKI)Zhang et al. [53] (2022)Retrospective, observational cohort study: 1,028 patients with primary nephrotic syndrome, AKI (n = 81), non-AKI (n = 947)Examination of serum free fatty acids by enzyme endpoint methodsPrematch, AKI patients were older, more often male, and had more infections, higher SBP, BMI, proteinuria, and serum free fatty acids (FFA), plus lower albumin and HDL. After propensity matching (77 pairs), multivariate analysis found infection, higher SBP, greater proteinuria, and higher FFA associated with AKI No FFA differences by stage or pathological type; FSGS had the highest AKI incidenceSerum FFA showed only weak diagnostic value for AKIin primary nephrotic syndromeZhou et al. [54] (2023)Prospective cohort study: 67 patients with sepsis associated AKI and 20 healthy controlsOxidative lipid analysis in plasma samples, liquid chromatography, tandem mass spectrometric detectionPlasma oxidative lipidomics reveals 21 significantly oxidized lipids. Machine learning (Random Forest, LASSO) highlighted five key biomarkers - particularly 9,10-DiHOME and 5,6-DiHETrE. Pathway analysis showed altered lipid metabolism, including downregulation of vascular smooth muscle contraction and involvement of serotonergic synapse pathwaysIdentification of 9,10-DiHOME and 5,6-DiHETrE as potential biomarkers for detecting sepsis associated AKI, 5-isoPGF2VI: a potential biomarker to distinguish AKI stage III from AKI stages I-II.Zhou et al. [48] (2025)Prospective cohort study in 17 patients with cardiac surgery-associated acute kidney injury (CSA-AKI) and 17 controlsLipidomic analysis through liquid chromatography-mass spectrometry (LC-MS)Broad lipidomic profiling found most differentially expressed lipids were upregulated in CSA-AKI, including acylcarnitines, cholesteryl esters, certain ceramides, lysophosphatidic acids, lysosphingomyelins, PG, and PIP species. Multivariate and network analyses implicated altered glycerophospholipid metabolism and flagged PE(14:0/22:2) and PE(39:1) as early-increased candidates, while PI(18:0/18:1) showed broad negative correlationsIdentification of PE(14:0/22:2) and PE(39:1) as early-increased candidates in CSA-AKIFatty acids, their metabolites and modulators of fatty acid metabolism in AKI managementHoogeveen et al. [64] (2014)2,344 patients with myocardial infarctionRandomization to 4 groups, substitution of eicosapentaenoic acid and docosahexaenoic acid, alpha-linolenic acid, eicosapentaenoic acid-docosahexaenoic acid and alpha-linolenic acid, or placebo for 40 months, eGFR measuredDaily EPA-DHA slows eGFR decline compared with placebo, with a larger benefit in those with baseline CKD. ALA showed no significant effect. EPA-DHA does not significantly reduce the incidence of CKD or rapid kidney-function decline, so effects were modest and variableLong-term supplementation with eicosapentaenoic acid-docosahexaenoic acid associated with small beneficial effects on kidney functionAlrowaie et al. [65] (2021)RCT: 130 patients undergoing coronary angiographyTwo groups: 67 received N-acetylcysteine (NAC), 63 received omega-3 fatty acid before interventionNAC group older with higher prevalence of hyperlipidemia, omega-3 group uses more ACEi/ARBs. Rates of contrast-induced nephropathy, kidney replacement therapy, in-hospital death, MI/stroke, and length of stay significantly not different between treatmentsOmega-3 fatty acids no beneficial effects on contrast-induced nephropathy. CI - (c) The Author(s) 2026. Published by S. Karger AG. LA - eng PT - Published Erratum DEP - 20260930 PL - Switzerland TA - Kidney Blood Press Res JT - Kidney & blood pressure research JID - 9610505 SB - IM EFR - Kidney Blood Press Res. 2026;51(1):567-588. doi: 10.1159/000552568. PMID: 42176287 EDAT- 2026/09/30 17:32 MHDA- 2026/09/30 17:32 CRDT- 2026/09/30 13:28 PHST- 2026/09/30 17:32 [medline] PHST- 2026/09/30 17:32 [pubmed] PHST- 2026/09/30 13:28 [entrez] AID - 000554466 [pii] AID - 10.1159/kbr/adjag008 [doi] PST - ppublish SO - Kidney Blood Press Res. 2026;51(1):915-922. doi: 10.1159/kbr/adjag008. Epub 2026 Sep 30. PMID- 42813554 OWN - NLM STAT- Publisher LR - 20260930 IS - 1467-1107 (Electronic) IS - 1047-9511 (Linking) DP - 2026 Sep 30 TI - Beyond the obvious in childhood obesity: exploring cardiac electrophysiological balance index and subclinical risk. PG - 1-6 LID - 10.1017/S1047951126124275 [doi] AB - BACKGROUND: Childhood obesity is associated with adverse cardiovascular outcomes, including increased risk of arrhythmias and subclinical myocardial dysfunction. However, its impact on cardiac electrophysiological balance remains underexplored. The index of cardiac electrophysiological balance, calculated as QT/QRS ratio and corrected form of index of cardiac electrophysiological balance, emerged as novel electrocardiographic markers of ventricular arrhythmia risk. Although these parameters have been investigated in adult populations, data in obese children are lacking. This study aimed to evaluate the effects of obesity on index of cardiac electrophysiological balance and corrected form of index of cardiac electrophysiological balance in children and explore their associations with metabolic and anthropometric measures. METHODS: This retrospective cross-sectional study included 50 obese, 23 healthy children aged 10-18 years. Demographic, metabolic, electrocardiographic, and echocardiographic data were retrieved from hospital records. Index of cardiac electrophysiological balance, corrected form of index of cardiac electrophysiological balance, and repolarisation indices (QTc dispersion, Tp-e dispersion, and P-wave dispersion) were manually measured from 12-lead electrocardiograms. Associations with metabolic and anthropometric parameters were analysed using linear regression. RESULTS: Index of cardiac electrophysiological balance and corrected form of index of cardiac electrophysiological balance values were significantly lower in obese children than in controls (p < 0.001). QTc, Tp-e, and P-wave dispersions were also increased, indicating greater electrical heterogeneity. Index of cardiac electrophysiological balance showed negative correlations with LDL and total cholesterol levels. Tp-e duration and Tp-e/QTc ratio were inversely associated with hip circumference z-scores, possibly reflecting protective effects of gluteofemoral fat distribution. CONCLUSION: Childhood obesity may disrupt cardiac electrophysiological balance and repolarisation, even in the absence of overt cardiovascular disease. Index of cardiac electrophysiological balance and corrected form of index of cardiac electrophysiological balance could serve as early markers of arrhythmia risk. Prospective studies are needed to validate their prognostic significance. FAU - Caglayan Bozlak, Ozlem Hilal AU - Caglayan Bozlak OH AUID- ORCID: 0000-0002-1002-8432 AD - Pediatrics, Marmara Universitesi Egitim ve Arastirma Hastanesi, Turkiye. ROR: https://ror.org/02kswqa67 FAU - Arici, Sule AU - Arici S AD - Pediatric Cardiology, Kartal Kosuyolu High Specialization Training and Research Hospital, Istanbul, Turkiye. FAU - Karagozlu, Selen AU - Karagozlu S AUID- ORCID: 0000-0002-9542-1937 AD - Pediatric Cardiology, Marmara University Department of Pediatric Cardiology, Turkiye. FAU - Akalin, Figen AU - Akalin F AD - Pediatric Cardiology, Marmara University Department of Pediatric Cardiology, Turkiye. LA - eng PT - Journal Article DEP - 20260930 PL - England TA - Cardiol Young JT - Cardiology in the young JID - 9200019 SB - IM OTO - NOTNLM OT - Cardiovascular risk in children OT - cardiac electrophysiological balance index OT - childhood obesity OT - electrocardiography OT - paediatric cardiology OT - subclinical arrhythmia EDAT- 2026/09/30 11:35 MHDA- 2026/09/30 11:35 CRDT- 2026/09/30 07:15 PHST- 2026/09/30 11:35 [medline] PHST- 2026/09/30 11:35 [pubmed] PHST- 2026/09/30 07:15 [entrez] AID - S1047951126124275 [pii] AID - 10.1017/S1047951126124275 [doi] PST - aheadofprint SO - Cardiol Young. 2026 Sep 30:1-6. doi: 10.1017/S1047951126124275. PMID- 42812512 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260930 LR - 20261001 IS - 1179-1411 (Print) IS - 1179-1411 (Electronic) IS - 1179-1411 (Linking) VI - 18 DP - 2026 TI - Assessing Vaginal Wall Elasticity via Shear-Wave Elastography Using a Transrectal Linear Array High-Frequency Probe in Premenopausal versus Postmenopausal Women: A Cross-Sectional Feasibility Study. PG - 640465 LID - 10.2147/IJWH.S640465 [doi] LID - 640465 AB - OBJECTIVES: This study aims to evaluate the feasibility of transrectal high-frequency linear array shear wave elastography (SWE) for assessing vaginal wall elasticity in women and to investigate potential differences in segmental elasticity values between premenopausal and postmenopausal populations. METHODS: This cross-sectional study included 228 women (164 premenopausal and 64 postmenopausal) who underwent gynecological ultrasound examinations at Hubei Maternal and Child Health Hospital from December 2024 to January 2025. Transrectal linear array high-frequency ultrasound examinations were performed by two ultrasound technicians. Tissue stiffness was assessed using Young's modulus measurements obtained from six standardized vaginal wall segments: upper, middle, and lower regions of both anterior and posterior walls. Inter-rater reliability was assessed by calculating the intraclass correlation coefficient (ICC). RESULTS: Linear mixed-effects modeling adjusting for age and BMI demonstrated that postmenopausal women exhibited significantly higher Young's modulus values (kPa) in the middle anterior wall (14.59 +/- 3.93 vs 12.88 +/- 3.87 kPa; adjusted P = 0.003, FDR q = 0.009) and middle posterior wall (14.87 +/- 4.09 vs 13.28 +/- 4.25 kPa; adjusted P = 0.013, FDR q = 0.026) compared with premenopausal women. Intra-group analysis revealed a significant proximal-to-distal stiffness gradient along the anterior wall in both premenopausal (P < 0.001) and postmenopausal (P = 0.001) groups, whereas the posterior wall displayed spatial homogeneity (P > 0.10). Inter-observer reliability was excellent, with ICCs ranging from 0.83 (0.68-0.94) to 0.95 (0.88-0.98) (P < 0.001). CONCLUSION: Transrectal SWE is a reliable, non-invasive method for evaluating segment-specific vaginal elasticity. Our study showed that postmenopausal tissue stiffening is localized to the middle vaginal canal rather than pan-vaginal, with an anterior proximal-to-distal elasticity gradient. While these findings advance understanding of regional biomechanical specialization, future large-scale, age-matched, and multicenter studies are required to validate these results and establish clinical diagnostic thresholds. CI - (c) 2026 Wu et al. FAU - Wu, Chunxiao AU - Wu C AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Zhou, Si AU - Zhou S AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Xu, Qianqian AU - Xu Q AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Zhao, Sheng AU - Zhao S AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Yang, Juan AU - Yang J AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Gao, Yanduo AU - Gao Y AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Huang, Cheng AU - Huang C AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Qian, Qingqing AU - Qian Q AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Zhu, Xia AU - Zhu X AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. LA - eng PT - Journal Article DEP - 20260924 PL - New Zealand TA - Int J Womens Health JT - International journal of women's health JID - 101531698 PMC - PMC13620308 OTO - NOTNLM OT - postmenopausal OT - premenopausal OT - transrectal high-frequency linear array OT - vaginal elasticity COIS- The authors report no conflicts of interest in this work. EDAT- 2026/09/30 11:35 MHDA- 2026/09/30 11:36 PMCR- 2026/09/24 CRDT- 2026/09/30 05:40 PHST- 2026/07/14 00:00 [received] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/09/30 11:36 [medline] PHST- 2026/09/30 11:35 [pubmed] PHST- 2026/09/30 05:40 [entrez] PHST- 2026/09/24 00:00 [pmc-release] AID - 640465 [pii] AID - 10.2147/IJWH.S640465 [doi] PST - epublish SO - Int J Womens Health. 2026 Sep 24;18:640465. doi: 10.2147/IJWH.S640465. eCollection 2026. PMID- 42812133 OWN - NLM STAT- MEDLINE DCOM- 20261006 LR - 20261007 IS - 1839-2628 (Electronic) IS - 1832-4274 (Linking) VI - 29 IP - 4 DP - 2026 Aug TI - Neonatal Health and Long-Term Outcomes: Twin-Based Evidence From Linked Scandinavian Registers. PG - 323-333 LID - 10.1017/thg.2026.10095 [doi] AB - This study examines the long-term consequences of neonatal health using three birth anthropometric measures - weight, length, and head circumference - and analyzes their differential associations with outcomes across the life course. Using linked Swedish and Norwegian population registers with follow-up into adulthood, we compare birth measures of singletons and twins and further estimate within-twin-pair fixed-effects models that control for shared genetic and family environmental factors. Our samples comprise up to approximately 679,000 singletons and 10,400 twins in Sweden, and 347,841 singletons and 6,762 twins in Norway, followed into adulthood. We find that different birth measures capture distinct aspects of fetal development with varying predictive validity across outcome domains. Birth length emerges as the strongest predictor of health outcomes (infant mortality, adult height), consistent with its role as a cumulative indicator of skeletal growth throughout gestation. Birth weight retains stronger associations with cognitive and educational outcomes (grade point average [GPA], years of schooling) in conditional models. Head circumference shows weak and inconsistent associations across specifications. Using within-pair head circumference differences to classify twins as symmetrically versus asymmetrically growth restricted, we find that symmetric intrauterine growth restriction is associated with substantially worse long-term outcomes than asymmetric restriction. In Norwegian twin pairs, growth restriction is associated with lower general cognitive ability (measured at military enlistment) relative to the unaffected co-twin; this within-pair deficit is more than twice as large for symmetric as for asymmetric restriction. We also document significant intergenerational transmission of birth anthropometrics, suggesting both environmental and genetic contributions. Finally, our register-based design with near-complete population coverage minimizes selection bias and attrition while providing statistical power for within-pair analyses across multiple outcomes. Exclusive reliance on birth weight may obscure important information about early-gestation developmental insults. FAU - Conti, Gabriella AU - Conti G AUID- ORCID: 0000-0003-4699-2490 AD - NHH, Norway. FAU - Buetikofer, Aline AU - Buetikofer A AD - Department of Economics and Social Research Institute, University College London, UK. FAU - Bjorkegren, Evelina AU - Bjorkegren E AD - Stockholm University, Sweden. FAU - Palme, Marten AU - Palme M AD - Stockholm University, Sweden. FAU - Salvanes, Kjell G AU - Salvanes KG AD - Department of Economics and Social Research Institute, University College London, UK. LA - eng PT - Journal Article PT - Twin Study PL - England TA - Twin Res Hum Genet JT - Twin research and human genetics : the official journal of the International Society for Twin Studies JID - 101244624 SB - IM MH - Humans MH - Female MH - *Registries MH - *Birth Weight MH - Infant, Newborn MH - Norway/epidemiology MH - Male MH - Adult MH - Sweden/epidemiology MH - *Infant Mortality MH - *Fetal Development MH - *Twins/genetics MH - Infant MH - Body Height MH - *Twins, Dizygotic/genetics OTO - NOTNLM OT - Birth length OT - Birth weight OT - Fetal origins OT - Head circumference OT - Intrauterine growth restriction OT - Linkage to administrative data OT - Twin studies EDAT- 2026/09/30 05:30 MHDA- 2026/10/06 11:31 CRDT- 2026/09/30 04:24 PHST- 2026/10/06 11:31 [medline] PHST- 2026/09/30 05:30 [pubmed] PHST- 2026/09/30 04:24 [entrez] AID - S1832427426100954 [pii] AID - 10.1017/thg.2026.10095 [doi] PST - ppublish SO - Twin Res Hum Genet. 2026 Aug;29(4):323-333. doi: 10.1017/thg.2026.10095. PMID- 42811307 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20261006 IS - 1471-2334 (Electronic) IS - 1471-2334 (Linking) VI - 26 IP - 1 DP - 2026 Aug 10 TI - Diagnostic performance of a centrifugation-free stool processing kit in conjunction with Xpert((R))MTB/RIF Ultra for paediatric tuberculosis: a multicentre prospective study in five low and middle-income countries. LID - 10.1186/s12879-026-13902-6 [doi] LID - 1736 AB - INTRODUCTION: Diagnosing paediatric tuberculosis (TB) remains challenging. Currently available diagnostic tests have limited accuracy, and most sampling methods are invasive. In 2021, the World Health Organization (WHO) endorsed the use of molecular WHO-recommended rapid diagnostic tests (mWRDs) with stool as an initial diagnostic tool for paediatric TB. In this study, we evaluated the diagnostic test accuracy (DTA) of stool samples processed with the Stool Processing Kit (SPK), one of three centrifugation-free methods available at the time. METHODS: We conducted a multi-centre prospective diagnostic validation study in South Africa, Tanzania, Malawi, Mozambique, and India. Children (< 15 years) under investigation for TB provided at least two (induced) sputum samples at enrolment, one stool sample, and one nasopharyngeal aspirate (NPA) if aged < 5 years and a chest x-ray. TB testing included Xpert((R)) MTB/RIF Ultra (Ultra) and culture. Diagnostic classification followed NIH consensus statements. Stool samples were processed using the SPK and tested with Ultra. We calculated DTA in the overall cohort and predefined subgroups of interest. RESULTS: Out of 5313 children screened, 975 were enrolled, and data from 817 children recruited between January 2019 and June 2021 were analysed. The overall microbiological confirmation rate was 203/817 (24.9%), and an additional 358/817 (43.8%) were classified as unconfirmed TB and 256/817 (31.3%) were classified as unlikely TB. The median age was 5.3 years (IQR: 2.0-9.2), and 390/817 (47.7%) of participants were under the age of five. 134/817 (16.4%) of children were living with HIV, and 88/817 (10.8%) had severe acute malnutrition (SAM). The overall sensitivity and specificity of SPK/Ultra against a Strict Reference Standard (SRS) were 33.8% (95% CI: 27.6-40.6) and 86.8% (95% CI: 80.5-91.3), respectively. Among children under one year of age and those with SAM, sensitivity was 43.3% (95% CI: 27.4-60.8) and 41.4% (95% CI: 25.5-59.3), respectively, with specificity reaching 100% in young children and 85% (95% CI: 64.0-94.8) in children with SAM. Classic TB symptoms and chest X-ray abnormalities at baseline were associated with increased likelihood of SPK/Ultra positivity. CONCLUSIONS: This is one of the largest studies to evaluate stool as an alternative specimen for diagnosing paediatric TB. Although the WHO's target product profile was not fully met, stool testing with SPK/Ultra represents a viable alternative to invasive sampling methods, especially in subgroups of interest. TRIAL REGISTRATION: ClinicalTrials.gov, NCT03734172, June 22, 2018. CI - (c) 2026. The Author(s). FAU - Banze, Denise AU - Banze D AD - Instituto Nacional de Saude (INS), Marracuene, Mozambique. denise.banze@ins.gov.mz. AD - CIH LMU Center for International Health, University Hospital, LMU Munich, Munich, Germany. denise.banze@ins.gov.mz. FAU - Olbrich, Laura AU - Olbrich L AD - Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany. AD - German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. AD - Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, Munich, Germany. FAU - Razid, Alia AU - Razid A AD - Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany. AD - German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. AD - Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Pettenkofer School of Public Health, Munich, Germany. FAU - Franckling-Smith, Zoe AU - Franckling-Smith Z AD - Department of Paediatrics & Child Health, SA-MRC Unit on Child & Adolescent Health, University of Cape Town, Cape Town, South Africa. FAU - Mfinanga, Alfred AU - Mfinanga A AD - CIH LMU Center for International Health, University Hospital, LMU Munich, Munich, Germany. AD - National Institute for Medical Research - Mbeya Medical Research Centre, Mbeya, Tanzania. FAU - Ntinginya, Nyanda Elias AU - Ntinginya NE AD - National Institute for Medical Research - Mbeya Medical Research Centre, Mbeya, Tanzania. FAU - Sabi, Issa AU - Sabi I AD - National Institute for Medical Research - Mbeya Medical Research Centre, Mbeya, Tanzania. AD - Department of Paediatric and Child Health, School of Medicine and Dentistry, University of Dodoma, Dodoma, Tanzania. FAU - Nliwasa, Marriot AU - Nliwasa M AD - TB/HIV Research Group, College of Medicine, Blantyre, Malawi. FAU - Semphere, Robina AU - Semphere R AD - TB/HIV Research Group, College of Medicine, Blantyre, Malawi. FAU - Corbett, Elizabeth L AU - Corbett EL AD - TB/HIV Research Group, College of Medicine, Blantyre, Malawi. AD - TB Center, London School of Hygiene and Tropical Medicine, London, UK. FAU - Michael, Joy Sarojini AU - Michael JS AD - Clinical Microbiology, Christian Medical College, Vellore, India. FAU - Verghese, Valsan Philip AU - Verghese VP AD - Pediatric Infectious Diseases, Christian Medical College, Vellore, India. FAU - Graham, Stephen M AU - Graham SM AD - Department of Paediatrics and Department of Respiratory Medicine, Royal Children's Hospital, University of Melbourne, Melbourne, Australia. FAU - Nabeta, Pamela AU - Nabeta P AD - Foundation for Innovative New Diagnostics (FIND), Geneva, Switzerland. FAU - Trollip, Andre AU - Trollip A AD - Foundation for Innovative New Diagnostics (FIND), Geneva, Switzerland. FAU - Song, Rinn AU - Song R AD - Oxford Vaccine Group, Department of Paediatrics, and the NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK. FAU - Larsson, Leyla AU - Larsson L AD - Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK. FAU - Geldmacher, Christof AU - Geldmacher C AD - Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany. AD - German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. FAU - Hoelscher, Michael AU - Hoelscher M AD - Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany. AD - German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. FAU - Zar, Heather J AU - Zar HJ AD - Department of Paediatrics & Child Health, SA-MRC Unit on Child & Adolescent Health, University of Cape Town, Cape Town, South Africa. FAU - Viegas, Sofia AU - Viegas S AD - Instituto Nacional de Saude (INS), Marracuene, Mozambique. FAU - Heinrich, Norbert AU - Heinrich N AD - Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany. AD - German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. AD - Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, Munich, Germany. FAU - Khosa, Celso AU - Khosa C AD - Instituto Nacional de Saude (INS), Marracuene, Mozambique. AD - Department of International Public Health and Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK. AD - Universidade Eduardo Mondlane, Maputo, Mozambique. LA - eng SI - ClinicalTrials.gov/NCT03734172 GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ PT - Clinical Trial PT - Journal Article PT - Multicenter Study DEP - 20260810 PL - England TA - BMC Infect Dis JT - BMC infectious diseases JID - 100968551 SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - *Feces/microbiology MH - India MH - Malawi MH - *Molecular Diagnostic Techniques/methods MH - Mozambique MH - Mycobacterium tuberculosis/isolation & purification/genetics MH - Prospective Studies MH - Rapid Diagnostic Tests MH - Sensitivity and Specificity MH - South Africa MH - *Specimen Handling/methods MH - Sputum/microbiology MH - Tanzania MH - *Tuberculosis/diagnosis/microbiology MH - *Developing Countries PMC - PMC13621693 OTO - NOTNLM OT - Child* OT - Diagnostics OT - Stool OT - Tuberculosis OT - mWRDs COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Ethics Committee of the Faculty of Medicine at Ludwig-Maximilians-University Munich, Germany; the University of Cape Town, Faculty of Health Sciences, Human Research Ethics Committee, South Africa; the Mbeya Medical Research and Ethics Committee, Tanzania; the Ministerio da Saude, Comite Nacional de Bioetica para a Saude, Mozambique; the College of Medicine Research and Ethics Committee (COMREC), Malawi; and the Office of Research Institutional Review Board, Christian Medical College, Vellore, India. The study was conducted in accordance with the Declaration of Helsinki. Written informed consent was obtained from caregivers or legal guardians of all participants, and assent was obtained from children in accordance with local ethical guidelines. Consent for publication: Consent for publication: Not applicable. This manuscript does not include any individual person's data in an identifiable form (including images). All data are presented in aggregate and/or de-identified. Competing interests: All authors have received funding from the European & Developing Countries Clinical Trials Partnership (EDCTP) to their respective institutions. Cepheid provided testing kits at no cost. EDAT- 2026/09/30 05:30 MHDA- 2026/09/30 05:31 PMCR- 2026/08/10 CRDT- 2026/09/29 23:53 PHST- 2025/12/26 00:00 [received] PHST- 2026/06/26 00:00 [accepted] PHST- 2026/09/30 05:31 [medline] PHST- 2026/09/30 05:30 [pubmed] PHST- 2026/09/29 23:53 [entrez] PHST- 2026/08/10 00:00 [pmc-release] AID - 10.1186/s12879-026-13902-6 [pii] AID - 13902 [pii] AID - 10.1186/s12879-026-13902-6 [doi] PST - epublish SO - BMC Infect Dis. 2026 Aug 10;26(1):1736. doi: 10.1186/s12879-026-13902-6. PMID- 42809071 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261029 IS - 1708-0428 (Electronic) IS - 0960-8923 (Linking) VI - 36 IP - 11 DP - 2026 Nov TI - Development and Validation of a Machine Learning Model for Predicting One-year Anemia After Bariatric Surgery: A Multicenter Study. PG - 5595-5606 LID - 10.1007/s11695-026-08965-y [doi] AB - INTRODUCTION: Anemia is a common nutritional complication after bariatric surgery, but preoperative tools for individualized risk assessment remain limited. This study aims to develop and externally validate a machine learning model for predicting anemia status one year after bariatric surgery. METHODS: This multicenter study included patients aged 16-65 years undergoing sleeve gastrectomy or Roux-en-Y gastric bypass. Patients from one hospital formed the derivation cohort, and patients from two independent hospitals formed the external validation cohort. Forty-five preoperative variables were evaluated using logistic regression, random forest, support vector machine, and extreme gradient boosting. Model discrimination, calibration, and clinical utility were assessed and compared with blinded predictions from 10 clinicians with different levels of experience. RESULTS: The derivation cohort included 511 patients (409 training, 102 internal testing), and the external cohort included 300 patients. One-year anemia occurred in 39.6%, 39.2%, and 19.0% of patients in the training, testing, and external validation cohorts, respectively. Random forest showed the most favorable overall performance profile and was simplified to seven predictors. The final model achieved an area under the curve of 0.827 (95% CI, 0.746-0.896) in the testing set and 0.823 (95% CI, 0.771-0.873) in the external validation cohort, with satisfactory calibration and decision-curve net benefit. In external validation, the model outperformed junior, middle-level, and senior clinicians and remained superior in clinician-defined challenging cases. CONCLUSIONS: A seven-variable preoperative model showed good discrimination for one-year anemia status after bariatric surgery and may support individualized postoperative monitoring and nutritional care. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Nie, Yuntao AU - Nie Y AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Wang, Tianshi AU - Wang T AD - Department of General Surgery, Second Hospital of Shandong University, Jinan, China. FAU - Tang, Haibo AU - Tang H AD - Department of General Surgery, Third Xiangya Hospital, Changsha, China. FAU - Huang, Yishan AU - Huang Y AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Wang, Zhe AU - Wang Z AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Wang, Pengpeng AU - Wang P AUID- ORCID: 0000-0002-0161-1933 AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Wang, Siqi AU - Wang S AUID- ORCID: 0000-0001-9401-0880 AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Liu, Genzheng AU - Liu G AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Lin, Ximing AU - Lin X AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Ran, Shuman AU - Ran S AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Liu, Yan AU - Liu Y AD - Department of Gastrointestinal Metabolic Surgery, Zhengzhou Central Hospital, Zhengzhou, China. FAU - Zhu, Ming AU - Zhu M AD - Department of Gastrointestinal Surgery, Jining First People's Hospital, Jining, China. FAU - Hu, Jingwei AU - Hu J AD - Department of Gastrointestinal Surgery, Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China. FAU - Li, Chunhui AU - Li C AD - Department of Endocrinology, Second Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Zhang, Nianrong AU - Zhang N AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Liu, Baoyin AU - Liu B AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Zhu, Liyong AU - Zhu L AUID- ORCID: 0000-0002-4666-8458 AD - Department of General Surgery, Third Xiangya Hospital, Changsha, China. zly8128@csu.edu.cn. FAU - Ding, Yinlu AU - Ding Y AD - Department of General Surgery, Second Hospital of Shandong University, Jinan, China. dingyinlu@126.com. FAU - Meng, Hua AU - Meng H AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. menghua@zryhyy.com.cn. LA - eng PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20260929 PL - United States TA - Obes Surg JT - Obesity surgery JID - 9106714 SB - IM MH - Humans MH - *Anemia/etiology/epidemiology/diagnosis MH - Female MH - Middle Aged MH - Adult MH - Predictive Learning Models MH - *Machine Learning MH - Male MH - Adolescent MH - *Postoperative Complications/etiology/epidemiology MH - *Bariatric Surgery/adverse effects MH - Random Forest MH - *Obesity, Morbid/surgery MH - Aged MH - Young Adult MH - Risk Assessment MH - Classification Algorithms MH - Prediction Algorithms MH - Boosting Machine Learning Algorithms MH - *Gastric Bypass/adverse effects MH - Gastrectomy/adverse effects OTO - NOTNLM OT - Bariatric surgery OT - Machine learning OT - Postoperative anemia OT - Prediction model COIS- Declarations. Ethical Approval: This study was conducted in accordance with the Helsinki Declaration and approved by the IRB of Hospital 1 (approval number blinded for peer review). Informed Consent: The requirement for informed consent was waived. Competing interests: The authors declare no competing interests. EDAT- 2026/09/29 19:04 MHDA- 2026/10/27 17:29 CRDT- 2026/09/29 11:12 PHST- 2026/06/25 00:00 [received] PHST- 2026/09/26 00:00 [accepted] PHST- 2026/09/15 00:00 [revised] PHST- 2026/10/27 17:29 [medline] PHST- 2026/09/29 19:04 [pubmed] PHST- 2026/09/29 11:12 [entrez] AID - 10.1007/s11695-026-08965-y [pii] AID - 10.1007/s11695-026-08965-y [doi] PST - ppublish SO - Obes Surg. 2026 Nov;36(11):5595-5606. doi: 10.1007/s11695-026-08965-y. Epub 2026 Sep 29. PMID- 42808984 OWN - NLM STAT- Publisher LR - 20260929 IS - 1935-5548 (Electronic) IS - 0149-5992 (Linking) DP - 2026 Sep 29 TI - Insulin Dose-Adjusted Hemoglobin A1c Has Suboptimal Performance for Identifying C-Peptide-Defined Partial Remission: The SEARCH for Diabetes in Youth Study. LID - dc261313 [pii] LID - 10.2337/dc26-1313 [doi] AB - OBJECTIVE: Insulin dose-adjusted hemoglobin A1c (IDAA1c = HbA1c [%] + [4 x total daily dose in units/kg/day]) /=85th percentile [overweight or obese]) using Wilcoxon rank sum and Fisher exact tests. Sensitivity, specificity, and receiver operating characteristic (ROC) AUC of IDAA1c /=0.91 ng/mL with an ROC AUC of 0.77. Among participants with overweight or obesity, sensitivity was 45% and specificity 81%. A Youden index-derived cutoff of IDAA1c 0.05). Higher PDI scores were associated with modestly lower odds of WHR-defined central obesity (adjusted OR = 0.972; 95% CI: 0.947-0.997; p = 0.031), whereas associations with WC- and WHtR-defined central obesity were not significant. CONCLUSION: PDI scores were not consistently associated with measures of general or central adiposity. Although higher scores were associated with modestly lower odds of WHR-defined central obesity, this isolated finding was not supported by the continuous adiposity outcomes and should be considered exploratory. Prospective studies are needed to determine whether this association is reproducible. CI - Copyright (c) 2026 Eman M. Alissa et al. BioMed Research International published by John Wiley & Sons Ltd. FAU - Alissa, Eman M AU - Alissa EM AUID- ORCID: 0000-0001-8905-4870 AD - Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia, kau.edu.sa. FAU - Algarni, Samiah A AU - Algarni SA AUID- ORCID: 0009-0005-1204-8639 AD - Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia, kau.edu.sa. FAU - Khaffji, Azza J AU - Khaffji AJ AD - Obstetrics and Gynecology, King Abdulaziz Hospital and Oncology Center, Jeddah, Saudi Arabia. FAU - Al Mansouri, Nisma M AU - Al Mansouri NM AUID- ORCID: 0000-0002-4346-1291 AD - Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia, kau.edu.sa. LA - eng GR - 30-37/King Abdulaziz City for Science and Technology/ PT - Journal Article PL - United States TA - Biomed Res Int JT - BioMed research international JID - 101600173 SB - IM MH - Humans MH - Female MH - Saudi Arabia/epidemiology MH - Adult MH - *Obesity/epidemiology/physiopathology MH - Body Mass Index MH - Waist-Hip Ratio MH - Adolescent MH - *Diet, Vegetarian MH - Cross-Sectional Studies MH - Waist Circumference/physiology MH - Young Adult MH - *Feeding Behavior MH - Adiposity PMC - PMC13621456 OTO - NOTNLM OT - BMI OT - FFQ OT - diet pattern OT - vegetarian OT - waist circumference OT - waist-to-hip ratio COIS- The authors declare no conflicts of interest. EDAT- 2026/09/29 12:28 MHDA- 2026/09/29 12:29 PMCR- 2026/09/29 CRDT- 2026/09/29 08:02 PHST- 2026/09/16 00:00 [revised] PHST- 2026/06/02 00:00 [received] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/09/29 12:29 [medline] PHST- 2026/09/29 12:28 [pubmed] PHST- 2026/09/29 08:02 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - BMRI4023284 [pii] AID - 10.1155/bmri/4023284 [doi] PST - ppublish SO - Biomed Res Int. 2026;2026(1):e4023284. doi: 10.1155/bmri/4023284. PMID- 42804465 OWN - NLM STAT- Publisher LR - 20260930 IS - 1469-445X (Electronic) IS - 0958-0670 (Print) IS - 0958-0670 (Linking) DP - 2026 Sep 28 TI - Association between dietary fatty acids and all-cause mortality in patients with cirrhosis: A cohort study. LID - 10.1113/EP093526 [doi] AB - Liver cirrhosis imposes a substantial global burden, with complications driving high mortality. Diet is pivotal in managing liver disease progression and cirrhosis-related death. This study investigated associations between total fat intake, specific dietary fatty acid subclasses and all-cause mortality in cirrhotic patients. In this prospective cohort study, 121 ambulatory patients with recently diagnosed cirrhosis (/=4 days/week) were significant associated with a lower probability of VD insufficiency. The global predictive scorecard achieved an optimism-corrected area under the receiver operating characteristic curve (optimism-corrected AUC) of 0.714. Crucially, the subgroup model restricted to overweight individuals (BMI >/= 25 kg/m(2)) demonstrated acceptable exploratory discrimination (optimism-corrected AUC = 0.768, sensitivity 69.2%, specificity 89.7%), serving as a preliminary proof-of-concept assessment for risk stratification. CONCLUSION: By integrating body composition dynamics and cultural habits, this cost-effective model provides a preliminary, exploratory non-invasive screening structure for Paraguayan youth that warrants further multi-center prospective validation before clinical implementation. CI - Copyright (c) 2026 Gonzalez, Mino, Espinoza, Cano, Recalde, Miguel and Ishikawa. FAU - Gonzalez, Anabel AU - Gonzalez A AD - Department of Biochemistry, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. FAU - Mino, Camila AU - Mino C AD - Department of Biochemistry, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. AD - Department of Medicine, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. FAU - Espinoza, Elena AU - Espinoza E AD - Department of Biochemistry, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. FAU - Cano, Marlene AU - Cano M AD - Department of Medicine, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. FAU - Recalde, Milciades AU - Recalde M AD - Department of Biochemistry, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. FAU - Miguel, Carlos AU - Miguel C AD - Department of Biochemistry, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. AD - Department of Medicine, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. FAU - Ishikawa, Dai AU - Ishikawa D AD - Department of Biochemistry, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. AD - Department of Medicine, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. AD - Japan International Cooperation Agency (JICA), Asuncion, Paraguay. LA - eng PT - Journal Article DEP - 20260911 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13612359 OTO - NOTNLM OT - body composition OT - logistic regression OT - mate consumption OT - predictive model OT - traditional habit OT - vitamin D insufficiency COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/27 02:27 MHDA- 2026/09/27 02:28 PMCR- 2026/09/11 CRDT- 2026/09/26 05:12 PHST- 2026/07/30 00:00 [received] PHST- 2026/08/16 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/09/27 02:28 [medline] PHST- 2026/09/27 02:27 [pubmed] PHST- 2026/09/26 05:12 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - 10.3389/fnut.2026.1953400 [doi] PST - epublish SO - Front Nutr. 2026 Sep 11;13:1953400. doi: 10.3389/fnut.2026.1953400. eCollection 2026. PMID- 42798427 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260927 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Physical literacy and adolescent mental well-being: A chain mediation of basic psychological needs satisfaction and emotion regulation. PG - 1950111 LID - 10.3389/fpsyg.2026.1950111 [doi] LID - 1950111 AB - BACKGROUND: Adolescent mental wellbeing is a pressing global concern. Physical literacy (PL) - the motivation, confidence, physical competence, knowledge, and understanding to value physical activity for life - has emerged as a potentially protective factor for mental wellbeing. However, the mechanisms linking PL to mental wellbeing remain poorly understood. Drawing on Self-Determination Theory and emotion regulation theory, this study examined whether basic psychological needs satisfaction (BPNS) and emotion regulation serve as sequential mediators in the PL-mental wellbeing relationship among adolescents. METHODS: A cross-sectional survey was conducted in November 2024 with 687 Chinese middle school students from Hubei Province (48.3% female; aged 12-16 years), recruited using stratified cluster sampling from three public schools. Participants completed validated Chinese measures of physical literacy (PPLI), basic psychological needs (BPNSFS), emotion regulation (ERQ), and mental wellbeing (WEMWBS). Covariance-based structural equation modeling (robust maximum likelihood) with bias-corrected bootstrapping (5,000 resamples) tested the chain mediation model. RESULTS: The final analytical sample comprised 687 adolescents (48.3% female), who reported moderate levels of PL (M = 3.42, SD = 0.68), BPNS (M = 3.56, SD = 0.62), cognitive reappraisal (M = 4.52, SD = 1.08), and mental wellbeing (M = 3.51, SD = 0.71). PL was positively associated with mental wellbeing (beta = 0.38, p < 0.001), the standardized total effect estimated in the structural equation model. The direct effect remained significant (beta = 0.14, p = 0.006). The chain mediation pathway - PL --> BPNS --> emotion regulation --> mental wellbeing - was significant (indirect effect = 0.12, 95% CI [0.08, 0.17]), accounting for 31.6% of the total effect. Individual mediation paths through BPNS (indirect effect = 0.05, 95% CI [0.01, 0.09]) and emotion regulation (indirect effect = 0.07, 95% CI [0.04, 0.11]) were also significant. The model explained 42% of the variance in mental wellbeing. CONCLUSION: These findings suggest that PL is associated with adolescent mental wellbeing through a sequential pathway involving BPNS and emotion regulation. The results highlight the potential value of PL development and need-supportive environments in educational settings. Future longitudinal research is needed to examine temporal dynamics. CI - Copyright (c) 2026 Zhang. FAU - Zhang, Bing AU - Zhang B AD - Institute of Physical Education, Huanggang Normal University, Huanggang, Hubei, China. LA - eng PT - Journal Article DEP - 20260911 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13612352 OTO - NOTNLM OT - Self-Determination Theory OT - adolescents OT - basic psychological needs satisfaction OT - chain mediation OT - emotion regulation OT - mental wellbeing OT - physical literacy COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/11 CRDT- 2026/09/26 04:58 PHST- 2026/07/27 00:00 [received] PHST- 2026/08/31 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 04:58 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1950111 [doi] PST - epublish SO - Front Psychol. 2026 Sep 11;17:1950111. doi: 10.3389/fpsyg.2026.1950111. eCollection 2026. PMID- 42797089 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 21 TI - Domain-Dependent Performance of Human Experts and AI Systems in Pediatric Menu Evaluation. LID - 10.3390/nu18183106 [doi] LID - 3106 AB - BACKGROUND/OBJECTIVES: Artificial intelligence (AI) tools are increasingly used for dietary assessment, but their reliability in pediatric nutrition remains uncertain. This study compared AI systems and human evaluators in pediatric menu assessment against expert-defined reference ratings. METHODS: This observational cross-sectional study used anonymized dietary and clinical information from three healthy pediatric cases. A multidisciplinary panel of pediatric nutrition specialists established standard evaluations. Assessments were completed by 84 AI evaluations, 116 nutrition specialists, 56 pediatric-focused physicians, and 88 physicians from other specialties. Outcomes included absolute error in total energy estimation, deviations in portion and qualitative ratings, standardized scores, and binary adequacy accuracy. Groups were compared using ANOVA or Kruskal-Wallis tests with post hoc analyses. RESULTS: A total of 344 assessments were included. Energy-estimation error differed between groups (Kruskal-Wallis = 12.85, p = 0.0016), but this analysis was based on a limited and highly unbalanced subset of 77 assessments. AI had the largest mean absolute error (260.3 +/- 194.3 kcal), followed by nutrition specialists (148.4 +/- 81.5 kcal); physicians with other specialties had the lowest error (60.4 +/- 53.3 kcal); these subgroup comparisons should be interpreted cautiously because of the small and unequal numbers of available energy estimates. AI showed greater portion-rating deviation (0.488; 95% CI: 0.38-0.60) than nutrition specialists (0.310; 95% CI: 0.20-0.42; p = 0.0019, q = 0.0059) and pediatric-focused physicians (0.286; 95% CI: 0.16-0.41; p = 0.0181, q = 0.019). Conversely, AI showed the lowest deviations for variety (0.37 +/- 0.49) and processing (0.33 +/- 0.47), compared with 1.15-1.36 and 1.22-1.57, respectively, among human groups (both p = 0.0001). CONCLUSIONS: AI may support structured pediatric menu screening for descriptive qualitative features; however, lower precision for energy and portion assessment supports, under these specific conditions, its use as an adjunct, for qualified nutrition professionals. FAU - Martin-Hadmas, Roxana Maria AU - Martin-Hadmas RM AUID- ORCID: 0000-0003-1499-5398 AD - Department of Community Nutrition and Food Safety, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, Gheorghe Marinescu 38, 540139 Targu Mures, Romania. FAU - Sovea, Rebeca AU - Sovea R AD - Department of Community Nutrition and Food Safety, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, Gheorghe Marinescu 38, 540139 Targu Mures, Romania. FAU - Pol, Diana AU - Pol D AD - Department of Community Nutrition and Food Safety, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, Gheorghe Marinescu 38, 540139 Targu Mures, Romania. FAU - Gavra, George Mihaita AU - Gavra GM AUID- ORCID: 0009-0007-9594-1231 AD - Center for Advanced Medical and Pharmaceutical Research, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania. FAU - Tarcea, Monica AU - Tarcea M AUID- ORCID: 0000-0001-7299-118X AD - Department of Community Nutrition and Food Safety, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, Gheorghe Marinescu 38, 540139 Targu Mures, Romania. FAU - Neghirla, Adriana AU - Neghirla A AD - Mures School Medicine Association, 540233 Targu Mures, Romania. FAU - Martin, Stefan Adrian AU - Martin SA AD - Center for Advanced Medical and Pharmaceutical Research, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania. LA - eng PT - Journal Article PT - Observational Study DEP - 20260921 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Artificial Intelligence MH - *Nutrition Assessment MH - Child MH - Female MH - Reproducibility of Results MH - Energy Intake MH - Male MH - *Menu Planning MH - Pediatrics MH - Nutritionists PMC - PMC13610824 OTO - NOTNLM OT - artificial intelligence OT - clinical decision support OT - dietary assessment OT - energy estimation OT - large language models OT - menu evaluation OT - nutrition professionals OT - pediatric nutrition COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/21 CRDT- 2026/09/26 01:15 PHST- 2026/08/17 00:00 [received] PHST- 2026/09/14 00:00 [revised] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:15 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - nu18183106 [pii] AID - nutrients-18-03106 [pii] AID - 10.3390/nu18183106 [doi] PST - epublish SO - Nutrients. 2026 Sep 21;18(18):3106. doi: 10.3390/nu18183106. PMID- 42797068 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 20 TI - Iodine Nutrition, Non-Genetic Factors, and Two Candidate Polymorphisms Associated with Thyroid Function Abnormalities Among Children Aged 8-10 Years in Iodine-Adequate Areas of Tianjin, China. LID - 10.3390/nu18183085 [doi] LID - 3085 AB - Background/Objectives: As dietary and environmental exposures change, interacting with genetic susceptibility, the prevalence of thyroid function abnormality and subclinical thyroid dysfunction in children is rising, yet systematic research in this population remains scarce. Methods: From 13 districts of Tianjin, China, all characterized by adequate iodine levels, 997 children between the ages of 8-10 years were recruited using a school-based sampling approach. Peripheral venous blood samples were drawn for genotyping analysis of two single nucleotide polymorphisms (SNPs): thyroid stimulating hormone receptor (TSHR) rs2268458 and NK2 homeobox 1 (NKX2-1) rs2076735 using the Sequenom MassARRAY platform. In addition, data on 31 non-genetic factors, including urinary iodine concentration (UIC), were collected. Restricted cubic spline (RCS) models were used to examine the non-linear associations between UIC and thyroid abnormalities. Multivariable Poisson regression was applied to identify factors associated with thyroid outcomes. Results: The overall prevalence of thyroid function abnormality in the study population was 17.35%, with detection rates of 3.51% for subclinical hyperthyroidism and 2.21% for subclinical hypothyroidism. After adjusting for age, sex, body mass index z-score (BMI-z-score), district of residence, and recruitment year, RCS models revealed significant U-shaped non-linear associations between UIC and both free triiodothyronine (FT(3)) abnormality (P(overall) = 0.003, P(nonlinear) < 0.001) and overall thyroid function abnormality (P(overall) = 0.042, P(nonlinear) = 0.029). In multivariable analysis, after Bonferroni correction within prespecified hypothesis families, family history of thyroid disease in first-degree relatives remained significantly associated with subclinical hyperthyroidism (adjusted p = 0.015), and UIC < 100 mug/L remained significantly associated with overall thyroid function abnormality (adjusted p = 0.036). In addition, district of residence was associated with subclinical hypothyroidism after correction (adjusted p = 0.009). Stratified analyses revealed potential subgroup-specific effects. Children with the NKX2-1 rs2076735 TT + TC genotype and UIC < 100 mug/L had a higher prevalence of thyroid function abnormality compared with the reference group (UIC 100-299 mug/L) (p = 0.031, PR = 3.093, 95% CI: 1.108, 8.636). Frequent consumption of kelp or laver soup was associated with a higher prevalence of subclinical hyperthyroidism among children with the NKX2-1 rs2076735 CC genotype or the TSHR rs2268458 TT genotype (p = 0.049, PR = 3.636, 95% CI: 1.006, 13.140; p = 0.023, PR = 4.814, 95% CI: 1.245, 18.610, respectively). Among children with the NKX2-1 rs2076735 CC genotype, those with a family history of thyroid disease had a higher prevalence of subclinical hyperthyroidism (p = 0.029, PR = 4.114, 95% CI: 1.152, 14.688). After Benjamini-Hochberg false discovery rate correction, none of the subgroup-specific associations remained statistically significant (adjusted p-values: 0.058-0.065). Conclusions: The prevalence of thyroid function abnormality and subclinical thyroid dysfunction was relatively high among school-aged children in this study population from Tianjin, China. After adjustment for covariates and correction for multiple comparisons, family history of thyroid disease, UIC < 100 mug/L, and district of residence remained significantly associated with subclinical hyperthyroidism, overall thyroid function abnormality, and subclinical hypothyroidism, respectively. A U-shaped association was observed between UIC and thyroid health, highlighting the importance of maintaining adequate iodine nutrition. However, stratified analyses suggested potential subgroup-specific associations that require validation in larger, independent cohorts. FAU - Duan, Yani AU - Duan Y AD - Institute of Environment and Public Health, Tianjin Centers for Disease Control and Prevention, 6 Huayue Road, Hedong District, Tianjin 300011, China. FAU - Wang, Yang AU - Wang Y AD - Institute of Environment and Public Health, Tianjin Centers for Disease Control and Prevention, 6 Huayue Road, Hedong District, Tianjin 300011, China. FAU - Li, Fang AU - Li F AD - Institute of Environment and Public Health, Tianjin Centers for Disease Control and Prevention, 6 Huayue Road, Hedong District, Tianjin 300011, China. FAU - Li, Wenfeng AU - Li W AD - Institute of Environment and Public Health, Tianjin Centers for Disease Control and Prevention, 6 Huayue Road, Hedong District, Tianjin 300011, China. FAU - Zhang, Dandan AU - Zhang D AD - Institute of Environment and Public Health, Tianjin Centers for Disease Control and Prevention, 6 Huayue Road, Hedong District, Tianjin 300011, China. FAU - Cui, Yushan AU - Cui Y AD - Institute of Environment and Public Health, Tianjin Centers for Disease Control and Prevention, 6 Huayue Road, Hedong District, Tianjin 300011, China. LA - eng GR - TJWJ2024QN091/Tianjin Health Research Project/ GR - 82173641/National Natural Science Foundation of China/ GR - TJYXZDXK-3-020B/Tianjin Key Medical Discipline Construction/ PT - Journal Article DEP - 20260920 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 9679TC07X4 (Iodine) RN - 0 (Receptors, Thyrotropin) RN - 0 (Thyroid Nuclear Factor 1) RN - 0 (TSHR protein, human) SB - IM MH - Humans MH - *Iodine/urine/administration & dosage/deficiency MH - China/epidemiology MH - Child MH - Female MH - Male MH - *Polymorphism, Single Nucleotide MH - Hyperthyroidism/genetics/epidemiology MH - *Thyroid Gland/physiopathology MH - *Receptors, Thyrotropin/genetics MH - Prevalence MH - Genetic Predisposition to Disease MH - *Hypothyroidism/genetics/epidemiology MH - *Nutritional Status MH - *Thyroid Nuclear Factor 1/genetics MH - *Thyroid Diseases/genetics/epidemiology MH - Thyroid Function Tests PMC - PMC13610479 OTO - NOTNLM OT - Iodine status OT - NKX2-1 OT - TSHR OT - children OT - subclinical thyroid dysfunction OT - thyroid function abnormality COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/20 CRDT- 2026/09/26 01:15 PHST- 2026/08/12 00:00 [received] PHST- 2026/09/11 00:00 [revised] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:15 [entrez] PHST- 2026/09/20 00:00 [pmc-release] AID - nu18183085 [pii] AID - nutrients-18-03085 [pii] AID - 10.3390/nu18183085 [doi] PST - epublish SO - Nutrients. 2026 Sep 20;18(18):3085. doi: 10.3390/nu18183085. PMID- 42797056 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 20 TI - Pro-Inflammatory Dietary Profiles Are Associated with Psychosocial Functioning in Spanish Adolescents: Findings from the EHDLA Study. LID - 10.3390/nu18183073 [doi] LID - 3073 AB - Background: Dietary factors may influence psychosocial outcomes through inflammatory pathways, but evidence in adolescents remains limited. The aim was to examine whether dietary inflammatory potential is associated with psychosocial functioning among Spanish adolescents. Methods: This cross-sectional study is based on a subsample from the Eating Healthy and Daily Life Activities (EHDLA) project, conducted in the Region of Murcia (Spain). Dietary inflammatory potential was assessed using a dietary inflammatory index (DII)-informed Food Frequency Questionnaire (FFQ)-derived inflammatory score based on a validated 45-item food frequency questionnaire. Behavioral functioning was evaluated using the Strengths and Difficulties Questionnaire (SDQ). Associations between DII-informed FFQ-derived inflammatory scores and SDQ outcomes were examined using robust linear regression models adjusted for sociodemographic, lifestyle, and anthropometric factors. Results: The analysis included 674 adolescents (57.1% girls; age: 14.0 [13.0-15.0] years). Higher DII-informed FFQ-derived inflammatory score (more pro-inflammatory diet) was associated with greater total behavioral difficulties (unstandardized beta coefficient [B] = 0.058; 95% confidence interval [CI]: 0.005-0.111; standardized beta = 0.099), conduct problems (B = 0.025; 95% CI: 0.011-0.039; beta = 0.148), hyperactivity/inattention (B = 0.032; 95% CI: 0.013-0.052; beta = 0.154), and externalizing problems (B = 0.056; 95% CI: 0.028-0.084; beta = 0.181), and with lower prosocial behavior (B = -0.029; 95% CI: -0.045 to -0.014; beta = -0.149). Multiple imputation sensitivity analyses yielded estimates in a similar direction, although the associations did not reach statistical significance. No significant associations were observed for emotional symptoms, peer relationship problems, or internalizing difficulties. Conclusions: Higher dietary inflammatory potential was associated with a less favorable psychosocial functioning profile among adolescents, particularly in externalizing domains. Longitudinal studies and anti-inflammatory dietary interventions are needed to determine whether the observed associations translate into meaningful changes in psychosocial functioning. FAU - Marrero-Fernandez, Paula AU - Marrero-Fernandez P AUID- ORCID: 0009-0009-0031-0408 AD - Department of Chemical Engineering and Pharmaceutical Technology, University of La Laguna, Avda. Astrofisico Francisco Sanchez s/n, 38001 Santa Cruz de Tenerife, Spain. FAU - Munoz-Pardeza, Jacinto AU - Munoz-Pardeza J AUID- ORCID: 0000-0002-0210-2866 AD - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain. FAU - Mino, Camila AU - Mino C AUID- ORCID: 0000-0002-9444-8564 AD - European Institute of Higher Studies (IEES), 4820-509 Fafe, Portugal. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AUID- ORCID: 0000-0002-7412-7624 AD - School of Medicine, Universidad Espiritu Santo, Samborondon 092301, Ecuador. AD - Faculty of Health Sciences, Universidad Autonoma de Chile, Temuco 4810101, Chile. FAU - Lopez-Moreno, Miguel AU - Lopez-Moreno M AUID- ORCID: 0000-0003-0553-6210 AD - Diet, Planetary Health and Performance, Faculty of Health Sciences, Universidad Francisco de Vitoria, 28223 Madrid, Spain. AD - Institute of Health and Sport Sciences, Faculty of Health Science, Universidad Francisco de Vitoria, 28223 Madrid, Spain. LA - eng PT - Journal Article DEP - 20260920 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - Female MH - Spain/epidemiology MH - Cross-Sectional Studies MH - Male MH - *Inflammation/psychology/etiology MH - *Diet/adverse effects MH - *Psychosocial Functioning MH - *Adolescent Behavior/psychology MH - Surveys and Questionnaires MH - Feeding Behavior PMC - PMC13610942 OTO - NOTNLM OT - adolescents OT - behavioral problems OT - diet-related inflammation OT - dietary inflammatory index OT - psychosocial functioning OT - strengths and difficulties questionnaire COIS- ML-M reports having previously received remuneration from Danone and Foods For Tomorrow for advisory board participation and consulting activities. These activities were unrelated to the submitted work and are not ongoing. At present, he has no active financial relationships with these entities. All other authors reported no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/20 CRDT- 2026/09/26 01:15 PHST- 2026/08/06 00:00 [received] PHST- 2026/09/08 00:00 [revised] PHST- 2026/09/10 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:15 [entrez] PHST- 2026/09/20 00:00 [pmc-release] AID - nu18183073 [pii] AID - nutrients-18-03073 [pii] AID - 10.3390/nu18183073 [doi] PST - epublish SO - Nutrients. 2026 Sep 20;18(18):3073. doi: 10.3390/nu18183073. PMID- 42797034 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260930 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 18 TI - Dietary Behaviours Mediate Intervention Effects on Body Composition Outcomes in Children: Evidence from a Cluster-Randomised Controlled Trial. LID - 10.3390/nu18183051 [doi] LID - 3051 AB - BACKGROUND/OBJECTIVES: Few paediatric obesity trials have examined behavioural mediators of intervention effects on detailed body composition outcomes beyond body mass index (BMI). Given the complexity of multiple correlated body composition indicators, this study aimed to employ principal component analysis (PCA) to derive a composite adiposity factor and to apply mediation analysis to identify whether changes in dietary behaviours and physical activity mediated the effects of the DECIDE-Children intervention on body composition. METHODS: This study included 1180 children from a 9-month cluster-randomised controlled trial that delivered a multifaceted, digitally assisted intervention targeting children (health education, physical activity reinforcement, and app-based BMI monitoring/feedback) and their environments (school food policies and family engagement). Outcomes were changes in body composition (whole-body and trunk fat mass, fat-free mass, and muscle mass indices measured by bioelectrical impedance analysis). Potential mediators included changes in dietary behaviour, screen time, and moderate-to-vigorous physical activity (MVPA), assessed via validated questionnaires. PCA was used to reduce the dimensionality of body composition variables and to derive a composite adiposity factor (PCA_1), with higher values indicating greater adiposity and lower muscle mass. Mediation was tested using linear mixed-effects models adjusted for age, sex, and region. RESULTS: The intervention significantly reduced adiposity indicators (e.g., whole-body and trunk fat mass percentage decreased by 1.003%, and PCA_1 decreased by 0.942 SD) and concurrently increased fat-free mass percentage and muscle mass percentage at both whole-body and trunk levels. Dietary behaviour significantly mediated the intervention effects on all body composition outcomes (e.g., mediating 16.1% of the effect on PCA_1), whereas physical activity (both screen time and MVPA) showed no mediation. Sensitivity analyses supported the primary findings. CONCLUSIONS: The DECIDE-Children intervention improved body composition by reducing adiposity and increasing fat-free and muscle mass percentage, effects primarily mediated by dietary behaviour. These findings highlight dietary behaviour as a key component in paediatric obesity intervention. FAU - Zhang, Li AU - Zhang L AUID- ORCID: 0000-0002-0367-0419 AD - Clinical Research Center for Children's Health and Diseases, Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan 250014, China. FAU - Wang, Lu AU - Wang L AD - National Health Commission Key Laboratory of Reproductive Health, Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China. FAU - Yin, Chun-Jie AU - Yin CJ AD - National Health Commission Key Laboratory of Reproductive Health, Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China. FAU - Duan, Yu-Qi AU - Duan YQ AD - National Health Commission Key Laboratory of Reproductive Health, Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China. FAU - Ma, Jiaolong AU - Ma J AD - School of Public Health, Shihezi University, Shihezi 832000, China. FAU - Yan, Shi-Yu AU - Yan SY AUID- ORCID: 0009-0003-4067-9652 AD - National Health Commission Key Laboratory of Reproductive Health, Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China. FAU - Chin, Yit Siew AU - Chin YS AUID- ORCID: 0000-0002-7609-1944 AD - Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia. FAU - Li, Yan AU - Li Y AUID- ORCID: 0000-0003-2233-7061 AD - Clinical Research Center for Children's Health and Diseases, Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan 250014, China. FAU - Wang, Hai-Jun AU - Wang HJ AUID- ORCID: 0000-0003-0849-2903 AD - School of Public Health, Shihezi University, Shihezi 832000, China. AD - National Health Commission Key Laboratory of Reproductive Health, Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China. LA - eng GR - Z20243204/Shandong Province Traditional Chinese Medicine Science and Technology Project/ GR - SFYZXET-202501/Shandong Maternal and Child Health Association Child Growth and Development Medical Research Project/ GR - 2016YFC1300204/National Key R&D Program of China/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20260918 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Female MH - Child MH - *Body Composition MH - Exercise MH - *Feeding Behavior MH - Adiposity MH - Body Mass Index MH - *Pediatric Obesity/prevention & control/therapy MH - Principal Component Analysis MH - *Diet MH - *Health Behavior MH - Cluster Analysis PMC - PMC13610272 OTO - NOTNLM OT - body composition OT - children OT - dietary behaviour OT - mediation analysis OT - obesity OT - principal component analysis OT - randomised controlled trial COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/18 CRDT- 2026/09/26 01:15 PHST- 2026/07/24 00:00 [received] PHST- 2026/09/09 00:00 [revised] PHST- 2026/09/12 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:15 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - nu18183051 [pii] AID - nutrients-18-03051 [pii] AID - 10.3390/nu18183051 [doi] PST - epublish SO - Nutrients. 2026 Sep 18;18(18):3051. doi: 10.3390/nu18183051. PMID- 42796999 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 15 TI - Tibetan Butter Tea Consumption and Cognitive Performance Among Tibetan Adolescents at High Altitude. LID - 10.3390/nu18183017 [doi] LID - 3017 AB - Background: Tibetan butter tea sits at a tension between the health concerns raised by its high salt and fat content and the potential cognitive benefits of its tea-derived constituents, yet whether this traditional beverage is associated with cognition in high-altitude Tibetan adolescents has not been directly examined. Methods: We conducted a school-based cross-sectional study of Tibetan students in grades 7-12 in Lhasa, Xizang, China, between June 2024 and June 2025. The analytic sample included 7967 students, with ages ranging from 10.18 to 24.82 years (mean +/- SD: 16.06 +/- 1.80). Butter tea consumption frequency was self-reported. Cognitive performance was assessed with Raven's Standard Progressive Matrices; low cognitive performance was defined as a score below the grade-specific 25th percentile. Logistic regression with cluster-robust standard errors estimated odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for demographic, family, socioeconomic, sleep, physical activity, and lifestyle factors, both overall and in sex-specific models. Results: Among 7967 Tibetan students, 3534 were male, and 4433 were female. Low cognitive performance was most prevalent among students reporting daily (29.56%) or never (26.34%) consumption and less prevalent among those reporting occasional (22.18%) or frequent (20.39%) consumption. Compared with never consumption, occasional consumption (aOR = 0.79; 95% CI, 0.70-0.88; p < 0.001) and frequent consumption (aOR = 0.71; 95% CI, 0.55-0.90; p = 0.004) were associated with lower odds of low cognitive performance. Daily consumption was not statistically significant. In sex-stratified analyses, frequent consumption was associated with lower odds among males (aOR = 0.68; 95% CI, 0.49-0.93; p = 0.018). Among females, both occasional (aOR = 0.76; 95% CI, 0.64-0.90; p = 0.001) and frequent (aOR = 0.74; 95% CI, 0.58-0.93; p = 0.011) consumption were associated with lower odds. Conclusions: Occasional and frequent consumption of Tibetan butter tea was associated with reduced odds of low cognitive performance among Tibetan adolescents at high altitude, with modest sex differences. These findings suggest that Tibetan butter tea should be evaluated as a culturally embedded whole-dietary exposure and may inform culturally sensitive school-based nutrition education and public health guidance in high-altitude Tibetan settings; however, causal inference cannot be established from this cross-sectional study, and longitudinal validation is needed. FAU - Deng, Liping AU - Deng L AD - Lhasa Center for Disease Control and Prevention, Lhasa 850005, China. FAU - Fang, Yuhang AU - Fang Y AD - Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai 200237, China. FAU - Pingcuo, Pingcuo AU - Pingcuo P AD - Lhasa Center for Disease Control and Prevention, Lhasa 850005, China. FAU - Cirenyangzong, Cirenyangzong AU - Cirenyangzong C AD - Lhasa Center for Disease Control and Prevention, Lhasa 850005, China. FAU - Zhao, Wenhu AU - Zhao W AD - Lhasa Center for Disease Control and Prevention, Lhasa 850005, China. FAU - Zhao, Junmei AU - Zhao J AD - Lhasa Center for Disease Control and Prevention, Lhasa 850005, China. FAU - Wang, Yanhui AU - Wang Y AD - Lhasa Center for Disease Control and Prevention, Lhasa 850005, China. FAU - Xu, Simin AU - Xu S AUID- ORCID: 0000-0003-4853-7598 AD - Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai 200237, China. FAU - Lian, Qiguo AU - Lian Q AUID- ORCID: 0000-0001-8307-0116 AD - Lhasa Center for Disease Control and Prevention, Lhasa 850005, China. AD - Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai 200237, China. LA - eng GR - XZ202301ZY0045G/Science and Technology Projects of Xizang Autonomous Region, China/ GR - XZ2023ZR-ZY25(Z)/Xizang Natural Science Foundation/ PT - Journal Article DEP - 20260915 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Tea) SB - IM MH - Humans MH - Female MH - Male MH - Adolescent MH - Tibet MH - *Altitude MH - *Cognition MH - Cross-Sectional Studies MH - *Tea MH - Child MH - Young Adult MH - Students PMC - PMC13610373 OTO - NOTNLM OT - Tibetan butter tea OT - Xizang OT - cognitive performance OT - high altitude OT - students COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/27 02:27 PMCR- 2026/09/15 CRDT- 2026/09/26 01:15 PHST- 2026/07/16 00:00 [received] PHST- 2026/09/11 00:00 [revised] PHST- 2026/09/12 00:00 [accepted] PHST- 2026/09/27 02:27 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:15 [entrez] PHST- 2026/09/15 00:00 [pmc-release] AID - nu18183017 [pii] AID - nutrients-18-03017 [pii] AID - 10.3390/nu18183017 [doi] PST - epublish SO - Nutrients. 2026 Sep 15;18(18):3017. doi: 10.3390/nu18183017. PMID- 42796957 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261002 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 11 TI - High Ultra-Processed Food Consumption but No Association with Quality of Life in Saudi Children and Adolescents with ADHD. LID - 10.3390/nu18182977 [doi] LID - 2977 AB - BACKGROUND/OBJECTIVES: Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity. Dietary interventions can potentially control ADHD symptoms, providing a non-pharmacological approach that may improve the quality of life (QoL). This cross-sectional study aimed to assess the association between ultra-processed food intake (UPF) and QoL in children and adolescents with ADHD in Saudi Arabia. METHODS: A total of 128 participants (66% males and 33% females) diagnosed with ADHD, aged 8-18 years, were assessed. A validated Saudi food frequency questionnaire was used to assess dietary intake; the degree of food processing was assessed using a novel classification system. The health-related QoL was measured using the Pediatric Quality of Life Inventory. RESULTS: Both the child (57.83 +/- 18.12) and parent perspectives (57.97 +/- 16.09) of QOL scores were lower than those of healthy norms across all domains. (p-value < 0.0001). The UPF represented the largest proportion of total energy intake (48.76 +/- 13.40%), followed by unprocessed or minimally processed foods (39.80 +/- 13.35%). Parent- and child-reported QoL scores were strongly correlated (p < 0.0001); both were significantly lower than the healthy normative values across all domains (p < 0.0001). Higher parental educational attainment was associated with better QoL scores from both the child's and parents' perspectives (p = 0.049 and p = 0.023, respectively). CONCLUSIONS: Children and adolescents with ADHD demonstrated high consumption of UPF and significantly lower QoL scores than healthy norms. No significant association was observed between UPF intake and QoL scores. Further studies are needed to better understand the factors influencing dietary quality and QoL among children and adolescents with ADHD. FAU - Alwaili, Lina M AU - Alwaili LM AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. FAU - Alsuhaibani, Norah S AU - Alsuhaibani NS AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. FAU - Alotaibi, Heton K AU - Alotaibi HK AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. FAU - Alkhudairy, Loujain A AU - Alkhudairy LA AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. FAU - Alanezi, Hana A AU - Alanezi HA AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. FAU - Aljahdali, Abeer A AU - Aljahdali AA AUID- ORCID: 0000-0003-3104-1019 AD - Department of Clinical Nutrition, Faculty of Applied Medical Sciences, King Abdulaziz University, P.O. Box 80215, Jeddah 21589, Saudi Arabia. AD - Department of Nutritional Sciences, University of Michigan, Ann Arbor, MI 48109, USA. FAU - Alshamri, Dalal F AU - Alshamri DF AUID- ORCID: 0000-0003-1516-4705 AD - Department of Clinical Nutrition, King Abdullah bin Abdulaziz University Hospital, P.O. Box 84428, Riyadh 11564, Saudi Arabia. FAU - Alzaben, Abeer S AU - Alzaben AS AUID- ORCID: 0000-0001-9813-1524 AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. LA - eng GR - PNURSP2026R207/Princess Nourah bint Abdulrahman University/ PT - Journal Article DEP - 20260911 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - *Attention Deficit Disorder with Hyperactivity/psychology MH - *Quality of Life MH - Saudi Arabia MH - Humans MH - Male MH - Female MH - Child MH - Adolescent MH - Cross-Sectional Studies MH - *Eating/psychology MH - Diet Surveys MH - *Diet/adverse effects/statistics & numerical data MH - *Fast Foods/adverse effects/classification/statistics & numerical data PMC - PMC13610857 OTO - NOTNLM OT - NOVA OT - adolescents OT - attention-deficit hyperactivity disorder OT - quality of life OT - ultra-processed food COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/27 02:27 PMCR- 2026/09/11 CRDT- 2026/09/26 01:14 PHST- 2026/08/17 00:00 [received] PHST- 2026/09/05 00:00 [revised] PHST- 2026/09/08 00:00 [accepted] PHST- 2026/09/27 02:27 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:14 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - nu18182977 [pii] AID - nutrients-18-02977 [pii] AID - 10.3390/nu18182977 [doi] PST - epublish SO - Nutrients. 2026 Sep 11;18(18):2977. doi: 10.3390/nu18182977. PMID- 42795970 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260929 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 18 DP - 2026 Sep 16 TI - Developmental Postural Modeling: A Historical and Conceptual Narrative Review of Posture Assessment. LID - 10.3390/jcm15187197 [doi] LID - 7197 AB - Background: Posture assessment has progressed from visual observation and descriptive classification to quantitative measurement, three-dimensional imaging, and artificial intelligence (AI)-assisted analyses. Despite these advances, uncertainty persists regarding normative interpretation, developmental significance, and prognosis, particularly during growth and maturation phases. Methods: This historical and conceptual narrative review synthesizes literature from PubMed/MEDLINE, Scopus, Web of Science, Google Scholar, and Semantic Scholar, with additional citation tracking and targeted searches of historical monographs and foundational sources. The final literature search was completed on 30 May 2026. The review was narrative rather than systematic, and no formal risk-of-bias or evidence-quality appraisal was performed. Reporting and methodological transparency were strengthened by referencing the SANRA principles for narrative reviews. Results: The literature supports several overlapping methodological traditions: observation and classification, quantitative measurement, three-dimensional reconstruction, and automated image- and data-based analysis. These approaches have accumulated rather than replaced one another. Across these traditions, a persistent measurement-interpretation gap remains: postural configuration can be characterized by increasing precision, whereas developmental reference trajectories and prognostic interpretations remain limited. Conclusions: Developmental Postural Modeling (DPM) is proposed as a hypothesis-generating conceptual framework for future research, initially emphasizing posture during childhood and adolescence, when growth and maturation are most explicit. The DPM is not a validated clinical tool and does not currently provide individual predictions or treatment recommendations. Its proposed role is to organize future longitudinal research integrating morphology, function, development, environment, time, advanced imaging, and computational analysis. FAU - Glinkowski, Wojciech Michal AU - Glinkowski WM AUID- ORCID: 0000-0003-2602-1128 AD - Center of Excellence "TeleOrto" for Telediagnostics and Treatment of Disorders and Injuries of the Locomotor System, Department of Medical Informatics and Telemedicine, Medical University of Warsaw, 02-091 Warsaw, Poland. AD - Polish Telemedicine and eHealth Society, 03-728 Warsaw, Poland. FAU - Sitnik, Robert AU - Sitnik R AUID- ORCID: 0000-0002-8156-5462 AD - Faculty of Mechatronics, Warsaw University of Technology, ul. sw. Andrzeja Boboli 8, 02-525 Warsaw, Poland. LA - eng PT - Journal Article PT - Review DEP - 20260916 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13607638 OTO - NOTNLM OT - anthropometry OT - artificial intelligence OT - auxology OT - body posture OT - developmental trajectories OT - postural development OT - posture classification OT - rasterstereography OT - spinal sagittal alignment OT - surface topography OT - three-dimensional reconstruction COIS- The authors declare no conflict of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/16 CRDT- 2026/09/26 01:12 PHST- 2026/06/21 00:00 [received] PHST- 2026/08/17 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:12 [entrez] PHST- 2026/09/16 00:00 [pmc-release] AID - jcm15187197 [pii] AID - jcm-15-07197 [pii] AID - 10.3390/jcm15187197 [doi] PST - epublish SO - J Clin Med. 2026 Sep 16;15(18):7197. doi: 10.3390/jcm15187197. PMID- 42795335 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260929 IS - 2075-1729 (Print) IS - 2075-1729 (Electronic) IS - 2075-1729 (Linking) VI - 16 IP - 9 DP - 2026 Sep 2 TI - Inter-Rater Reliability of the Progressive Pain Check Method for Standardized Pain Assessment in Lipedema. LID - 10.3390/life16091471 [doi] LID - 1471 AB - BACKGROUND: Lipedema is a chronic progressive condition affecting approximately 10% of women, characterized by disproportionate subcutaneous adipose tissue accumulation and pain in the lower extremities. Standardized assessment methods for pain evaluation in lipedema remain limited. The Progressive Pain Check (PPC) method represents a potentially valuable tool for standardized pain assessment in lipedema patients. OBJECTIVE: To evaluate the inter-rater reliability of the PPC method for clinical assessment of evoked pain in lipedema patients. METHODS: Two independent assessors performed PPC evaluations. Inter-rater reliability was assessed using the Intraclass Correlation Coefficient [ICC(2,1), two-way random-effects, absolute agreement, single-measurement] with 95% confidence intervals (CI). RESULTS: This study included 429 women diagnosed with lipedema (mean age 41.2 +/- 11.5 years, mean disease duration 27.2 +/- 12.6 years). Patient characteristics revealed mean BMI of 29.5 +/- 6.9 kg/m(2), predominantly Type III lipedema presentation, and disease onset during adolescence (mean age 14 +/- 9.3 years). The PPC method demonstrated excellent inter-rater reliability between two independent assessors across all examined anatomical districts. CONCLUSIONS: The PPC method shows promise as a simple, repeatable, and standardized clinical tool for evoked pain assessment in lipedema patients. The demonstrated inter-rater reliability supports its potential utility in clinical practice. Further research is warranted to evaluate its intra-rater reliability, concurrent validity, and responsiveness in monitoring treatment effects. FAU - Patton, Laura AU - Patton L AUID- ORCID: 0009-0008-2024-4607 AD - Endocrinology and Lymphology Clinic, 38096 Vallelaghi, Italy. FAU - Ricolfi, Lorenzo AU - Ricolfi L AUID- ORCID: 0009-0000-7216-9612 AD - Endocrinology and Lymphology Clinic, 38096 Vallelaghi, Italy. FAU - Elhadidy, Heba Safwat Mhmoued Abdo AU - Elhadidy HSMA AUID- ORCID: 0000-0002-8425-8580 AD - Department of Public Health Sciences and Paediatrics, University of Turin, 10126 Torino, Italy. FAU - Reverdito, Valeria AU - Reverdito V AD - Human Project Studio, 10138 Torino, Italy. FAU - Russotto, Antonino AU - Russotto A AUID- ORCID: 0000-0002-5925-2240 AD - Department of Public Health Sciences and Paediatrics, University of Turin, 10126 Torino, Italy. FAU - Politano, Gianfranco AU - Politano G AUID- ORCID: 0000-0001-5268-9899 AD - Department of Control and Computer Engineering, Politecnico di Torino, 10129 Torino, Italy. FAU - Gianino, Maria Michela AU - Gianino MM AD - Department of Public Health Sciences and Paediatrics, University of Turin, 10126 Torino, Italy. LA - eng PT - Journal Article DEP - 20260902 PL - Switzerland TA - Life (Basel) JT - Life (Basel, Switzerland) JID - 101580444 PMC - PMC13608010 OTO - NOTNLM OT - allodynia OT - clinical OT - examination OT - inter-rater reliability OT - lipedema OT - pain assessment COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/02 CRDT- 2026/09/26 01:10 PHST- 2026/07/21 00:00 [received] PHST- 2026/08/29 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:10 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - life16091471 [pii] AID - life-16-01471 [pii] AID - 10.3390/life16091471 [doi] PST - epublish SO - Life (Basel). 2026 Sep 2;16(9):1471. doi: 10.3390/life16091471. PMID- 42794587 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 27 IP - 18 DP - 2026 Sep 13 TI - Obesity, Oxidative Stress, and Inflammation in Precocious Puberty: Do All Roads Lead to the Hypothalamus? LID - 10.3390/ijms27188159 [doi] LID - 8159 AB - Childhood obesity is consistently associated with earlier pubertal timing, particularly in girls, whereas its relationship with true central precocious puberty (CPP), defined by premature activation of the hypothalamic-pituitary-gonadal (HPG) axis, is less clearly established. An increased frequency of CPP diagnoses and referrals was reported during the COVID-19 pandemic, alongside changes in body weight, lifestyle, sleep, and psychosocial exposures. Human studies link excess adiposity to hyperleptinemia, insulin resistance, reduced adiponectin, altered sex-steroid bioavailability, and systemic low-grade inflammation, and associate these features with earlier pubertal development-consistently in girls, less so in boys. However, such associations do not establish that obesity directly induces premature hypothalamic activation. Mechanistic understanding of how these peripheral signals may influence pubertal timing derives predominantly from experimental models. The arcuate nucleus kisspeptin/neurokinin B/dynorphin (KNDy) network, a key component of the gonadotropin-releasing hormone (GnRH) pulse generator, interacts with hypothalamic metabolic circuits. In animal models of obesity and overnutrition, altered leptin and insulin signaling, mitochondrial reactive oxygen species generation, and activation of microglia and astrocytes remodel the mediobasal hypothalamus through inflammatory and stress-responsive pathways, including IKKbeta/NF-kappaB and JNK signaling and altered Nrf2-mediated antioxidant defenses. At the molecular level, metabolic status interacts with the epigenetic machinery governing Kiss1 expression: in rodent models of overnutrition, accelerated loss of SIRT1-mediated repression at the Kiss1 promoter facilitates pubertal activation. Human genetic evidence establishes MKRN3 and DLK1 as causes of familial CPP, but evidence that obesity modifies these pathways to induce sporadic CPP is insufficient. Similarly, gut microbial metabolites have been linked experimentally to pubertal timing, and antioxidant micronutrients such as selenium, zinc, and vitamins C and E may be altered in pediatric obesity, yet a specific role in CPP remains unproven. Collectively, current evidence supports a working model in which metabolic, inflammatory, redox, glial, and epigenetic pathways may converge on hypothalamic reproductive circuits to influence pubertal timing in susceptible children. Direct evidence in children with CPP-of hypothalamic oxidative stress, glial activation, Nrf2 dysfunction, SIRT1 remodeling, or microbiome-mediated activation-remains limited or absent. Lifestyle optimization is appropriate for improving metabolic health in children with obesity, whereas antioxidant, micronutrient, and microbiome-targeted interventions should be considered investigational with respect to CPP. Longitudinal pediatric studies that distinguish earlier pubertal timing from true CPP, and that integrate metabolic phenotyping with validated measures of HPG-axis activation, are needed to test this framework. FAU - Bizerea-Moga, Teofana-Otilia AU - Bizerea-Moga TO AUID- ORCID: 0000-0002-1599-5579 AD - Department XI of Pediatrics, First Pediatric University Clinic, Center for Research on Growth and Developmental Disorders in Children, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. AD - 1st Pediatric Clinic, 'Louis Turcanu' Children's Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timisoara, Romania. FAU - Chisavu, Flavia AU - Chisavu F AD - Nephrology University Clinic, Centre for Molecular Research in Nephrology and Vascular Disease, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. AD - 4th Pediatric Clinic, 'Louis Turcanu' Children's Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timisoara, Romania. FAU - Chisavu, Lazar AU - Chisavu L AUID- ORCID: 0000-0003-3664-1945 AD - Nephrology University Clinic, Centre for Molecular Research in Nephrology and Vascular Disease, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. AD - Nephrology Clinic, 'Pius Brinzeu' County Emergency Clinical Hospital, Liviu Rebreanu 156, 300723 Timisoara, Romania. FAU - Pitulice, Laura AU - Pitulice L AUID- ORCID: 0000-0002-5991-6203 AD - Department of Chemistry, West University of Timisoara, Pestallozi 16, 300115 Timisoara, Romania. AD - Institute of Advanced Environmental Research, Oituz 4c, 300086 Timisoara, Romania. FAU - Moga, Tudor Voicu AU - Moga TV AUID- ORCID: 0000-0002-8978-1856 AD - Department VII of Internal Medicine, Gastroenterology University Clinic, Advanced Regional Research Center in Gastroenterology and Hepatology, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. AD - Gastroenterology and Hepatology Clinic, 'Pius Brinzeu' County Emergency Clinical Hospital, Liviu Rebreanu 156, 300723 Timisoara, Romania. FAU - Bugi, Meda-Ada AU - Bugi MA AD - 1st Pediatric Clinic, 'Louis Turcanu' Children's Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timisoara, Romania. AD - Department of Pharmacy, University of Medicine and Pharmacy 'Vasile Goldis', 310025 Arad, Romania. FAU - Foghis, Cornel Flavius AU - Foghis CF AUID- ORCID: 0009-0009-4621-274X AD - Department XI of Pediatrics, First Pediatric University Clinic, Center for Research on Growth and Developmental Disorders in Children, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. AD - 1st Pediatric Clinic, 'Louis Turcanu' Children's Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timisoara, Romania. AD - Ph.D. School Department, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. FAU - Isac, Raluca AU - Isac R AUID- ORCID: 0000-0003-1478-9797 AD - 4th Pediatric Clinic, 'Louis Turcanu' Children's Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timisoara, Romania. AD - Department XI of Pediatrics, Third Pediatric University Clinic, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. FAU - Marginean, Otilia AU - Marginean O AUID- ORCID: 0000-0003-2313-7643 AD - Department XI of Pediatrics, First Pediatric University Clinic, Center for Research on Growth and Developmental Disorders in Children, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. AD - 1st Pediatric Clinic, 'Louis Turcanu' Children's Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timisoara, Romania. FAU - Balica, Nicolae Constantin AU - Balica NC AUID- ORCID: 0000-0001-7755-4608 AD - Department IX, Otolaryngology University Clinic, OftalmoSensory-Tumor Research Center-ORL (EYE-ENT), 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania. AD - Otorhinolaryngology Clinic, Emergency City Hospital, 300054 Timisoara, Romania. LA - eng PT - Journal Article PT - Review DEP - 20260913 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 SB - IM MH - Humans MH - *Puberty, Precocious/metabolism/pathology/etiology MH - *Oxidative Stress MH - Animals MH - *Inflammation/metabolism/complications MH - *Hypothalamus/metabolism/pathology MH - *Obesity/metabolism/complications MH - Hypothalamic-Pituitary-Gonadal Axis MH - Female PMC - PMC13607323 OTO - NOTNLM OT - KNDy neurons OT - hypothalamus OT - neuroinflammation OT - obesity OT - oxidative stress OT - precocious puberty COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/13 CRDT- 2026/09/26 01:08 PHST- 2026/07/22 00:00 [received] PHST- 2026/09/08 00:00 [revised] PHST- 2026/09/10 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:08 [entrez] PHST- 2026/09/13 00:00 [pmc-release] AID - ijms27188159 [pii] AID - ijms-27-08159 [pii] AID - 10.3390/ijms27188159 [doi] PST - epublish SO - Int J Mol Sci. 2026 Sep 13;27(18):8159. doi: 10.3390/ijms27188159. PMID- 42794468 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 27 IP - 18 DP - 2026 Sep 9 TI - Targeted 3.34-Million CpG Site Sequencing Reveals Preliminary Cord Blood Epigenetic Alterations of Autism Spectrum Disorder: A Pilot Study Highlighting the PCDHA1-PCDHA8 Cluster. LID - 10.3390/ijms27188038 [doi] LID - 8038 AB - Rising reported Autism Spectrum Disorder (ASD) prevalence underscores the need to explore early perinatal biological markers. To conduct an exploratory pilot investigation of cord blood DNA methylation patterns as potential early epigenetic candidate loci associated with ASD in infants born to mothers with obesity and gestational diabetes. This prospective pilot study analyzed 14 mother-infant pairs comprising infants born to mothers with obesity and gestational diabetes later diagnosed with ASD (n = 2); healthy infants born to mothers with obesity and diabetes (IODM, n = 6); and healthy controls (IHM, n = 6). Targeted methyl-capture sequencing (covering 3.34 million CpG sites) identified differentially methylated region (DMR)-associated genes. Neurodevelopment was evaluated at 24-26 months using Bayley-III scales. ASD infants showed lower Bayley-III scores across all domains. In this small cohort (n = 2 ASD cases), we identified 249 DMR-associated genes common to both ASD vs. IHM and ASD vs. IODM comparisons, representing preliminary candidate loci. Enrichment analysis identified homophilic cell-cell adhesion as the most significant pathway (fold enrichment = 8.28; FDR = 6.31 x 10(-6)), driven by the PCDH1-PCDHA8 cluster, alongside morphogenesis in neuron differentiation (fold enrichment = 3.45; FDR = 2.08 x 10(-2)). Although prospective validation in larger independent cohorts is required, these pilot results suggest that cord blood PCDHA1-PCDHA8 cluster methylation alterations represent preliminary candidate loci for hypothesis generation and future biomarker evaluation, regardless of maternal metabolic status. FAU - Armas-Gonzalez, Marina AU - Armas-Gonzalez M AD - Obstetrics and Gynecology Department, Seccion de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain. AD - Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Maranon, 28007 Madrid, Spain. FAU - Gonzalez-Gonzalez, Nieves Luisa AU - Gonzalez-Gonzalez NL AUID- ORCID: 0000-0003-1401-5580 AD - Obstetrics and Gynecology Department, Seccion de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain. FAU - Gonzalez-Davila, Enrique AU - Gonzalez-Davila E AUID- ORCID: 0000-0002-0781-9161 AD - Mathematics, Statistics and Operations Research Department (IMAULL), University of La Laguna (ULL), 38320 La Laguna, Spain. FAU - Orribo-Morales, Olivia AU - Orribo-Morales O AD - Obstetrics and Gynecology Department, Seccion de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain. AD - Department of Obstetrics and Gynecology, Canary Islands University Hospital, 38320 La Laguna, Spain. FAU - Castro-Conde, Jose Ramon AU - Castro-Conde JR AUID- ORCID: 0000-0003-0867-2920 AD - Obstetrics and Gynecology Department, Seccion de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain. AD - Pediatrics Department, Canary Islands University Hospital, 38320 La Laguna, Spain. FAU - Gonzalez-Campos, Candelaria AU - Gonzalez-Campos C AD - Obstetrics and Gynecology Department, Seccion de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain. AD - Pediatrics Department, Canary Islands University Hospital, 38320 La Laguna, Spain. FAU - Flores, Carlos AU - Flores C AUID- ORCID: 0000-0001-5352-069X AD - Research Unit, Hospital Universitario Ntra. Sra. de Candelaria, Instituto de Investigacion Sanitaria de Canarias (IISC), 38010 Santa Cruz de Tenerife, Spain. AD - CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, Spain. AD - Genomics Division, Instituto Tecnologico y de Energias Renovables (ITER), 38600 Santa Cruz de Tenerife, Spain. FAU - Lorenzo-Salazar, Jose Miguel AU - Lorenzo-Salazar JM AUID- ORCID: 0000-0002-5135-2861 AD - Genomics Division, Instituto Tecnologico y de Energias Renovables (ITER), 38600 Santa Cruz de Tenerife, Spain. FAU - Gonzalez-Montelongo, Rafaela AU - Gonzalez-Montelongo R AUID- ORCID: 0000-0001-9022-8663 AD - Genomics Division, Instituto Tecnologico y de Energias Renovables (ITER), 38600 Santa Cruz de Tenerife, Spain. FAU - Munoz-Barrera, Adrian AU - Munoz-Barrera A AUID- ORCID: 0000-0002-1561-5898 AD - Genomics Division, Instituto Tecnologico y de Energias Renovables (ITER), 38600 Santa Cruz de Tenerife, Spain. FAU - Padron-Perez, Erika AU - Padron-Perez E AUID- ORCID: 0000-0001-5243-3244 AD - Obstetrics and Gynecology Department, Seccion de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain. AD - Department of Obstetrics and Gynecology, Canary Islands University Hospital, 38320 La Laguna, Spain. FAU - Tascon-Padron, Laura AU - Tascon-Padron L AUID- ORCID: 0000-0001-9941-9001 AD - Department of Obstetrics and Prenatal Medicine, University Hospital Bonn, 53127 Bonn, Germany. FAU - Nunez Catalan, Maria AU - Nunez Catalan M AD - Obstetrics and Gynecology Department, Seccion de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain. LA - eng GR - PI18/01700/Instituto de Salud Carlos III/ PT - Journal Article DEP - 20260909 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - 0 (Cadherins) SB - IM MH - Humans MH - *Fetal Blood/metabolism MH - Female MH - Pilot Projects MH - *DNA Methylation MH - *Epigenesis, Genetic MH - *CpG Islands/genetics MH - *Autism Spectrum Disorder/genetics MH - Pregnancy MH - *Cadherins/genetics MH - Male MH - Diabetes, Gestational/genetics MH - Prospective Studies MH - Adult MH - Case-Control Studies MH - Infant PMC - PMC13607789 OTO - NOTNLM OT - DNA OT - autism OT - cord blood OT - diabetes OT - enrichment analysis OT - epigenetic OT - maternal obesity OT - neurodevelopment OT - pregnancy OT - protocadherins COIS- The authors declare no conflict of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/09 CRDT- 2026/09/26 01:07 PHST- 2026/07/30 00:00 [received] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:07 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - ijms27188038 [pii] AID - ijms-27-08038 [pii] AID - 10.3390/ijms27188038 [doi] PST - epublish SO - Int J Mol Sci. 2026 Sep 9;27(18):8038. doi: 10.3390/ijms27188038. PMID- 42794221 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260929 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 9 DP - 2026 Sep 5 TI - Discriminatory Capacity of Anthropometric Indicators and Physical Fitness Tests for Identifying Waist-to-Height Ratio-Defined Cardiometabolic Risk in Adolescents According to Sex and Biological Maturity. LID - 10.3390/children13091201 [doi] LID - 1201 AB - BACKGROUND/OBJECTIVES: Field-based health screening in adolescents requires accurate, non-invasive, and feasible diagnostic tools. This study evaluated the discriminatory capacity of anthropometric parameters and physical fitness tests for identifying waist-to-height ratio (WHtR)-defined surrogate cardiometabolic risk across sex and biological maturity status, determining exploratory cut-off thresholds. METHODS: A cross-sectional study was conducted with 2944 Spanish adolescents (1459 males, 1485 females; age: 13.35 +/- 1.20 years). Anthropometric variables (BMI, skinfolds, fat/muscle mass) and physical fitness tests (20-m shuttle run, handgrip, CMJ, SBJ, 20-m sprint, curl-up; evaluated in raw and body-mass-normalized formats) were assessed. Biological maturation was estimated via Age at Peak Height Velocity (APHV) using Mirwald equations and categorized into early, on-time, and late maturers relative to the sample mean. Surrogate risk was operationalized strictly as WHtR >/= 0.50, without direct assessment of biochemical or hemodynamic parameters. Receiver operating characteristic (ROC) curves, optimal Youden-derived cut-offs, and internal bootstrap validation (1000 resamples) were performed. RESULTS: Anthropometric parameters demonstrated high discriminatory performance for detecting WHtR-defined surrogate risk across all sex and maturation cohorts (AUC = 0.88-0.98). Unadjusted physical fitness tests showed poor overall classification performance. However, normalizing fitness metrics for body mass (particularly relative CMJ and cardiorespiratory fitness) substantially improved discriminatory capacity. Optimal cut-off values for anthropometric indicators displayed an observed descending pattern across progressively later-maturing cohorts. CONCLUSIONS: Anthropometric parameters represent highly accurate field proxies for WHtR-defined surrogate risk screening in adolescents. While unadjusted fitness metrics have limited utility for this anthropometric outcome, body-mass-normalized fitness parameters substantially recover classification capacity. Biological maturation timing should be carefully considered when future research derives and externally validates adolescent screening thresholds, as current cut-offs remain exploratory and sample-derived. FAU - Lopez-Lombo, Victoria AU - Lopez-Lombo V AD - Research Group Movement Sciences and Sport (MS&SPORT), Department of Physical Activity and Sport Sciences, Faculty of Sport Sciences, University of Murcia, 30720 San Javier, Murcia, Spain. FAU - Mateo-Orcajada, Adrian AU - Mateo-Orcajada A AUID- ORCID: 0000-0001-8111-8358 AD - Research Group Movement Sciences and Sport (MS&SPORT), Department of Physical Activity and Sport Sciences, Faculty of Sport Sciences, University of Murcia, 30720 San Javier, Murcia, Spain. FAU - Abenza-Cano, Lucia AU - Abenza-Cano L AUID- ORCID: 0000-0001-9583-737X AD - Facultad de Deporte, UCAM Universidad Catolica San Antonio de Murcia, 30107 Guadalupe, Murcia, Spain. FAU - Abraldes, J Arturo AU - Abraldes JA AUID- ORCID: 0000-0003-4527-3865 AD - Research Group Movement Sciences and Sport (MS&SPORT), Department of Physical Activity and Sport Sciences, Faculty of Sport Sciences, University of Murcia, 30720 San Javier, Murcia, Spain. FAU - Albaladejo-Saura, Mario AU - Albaladejo-Saura M AUID- ORCID: 0000-0003-0234-7756 AD - Facultad de Deporte, UCAM Universidad Catolica San Antonio de Murcia, 30107 Guadalupe, Murcia, Spain. FAU - Vaquero-Cristobal, Raquel AU - Vaquero-Cristobal R AUID- ORCID: 0000-0003-2708-4817 AD - Research Group Movement Sciences and Sport (MS&SPORT), Department of Physical Activity and Sport Sciences, Faculty of Sport Sciences, University of Murcia, 30720 San Javier, Murcia, Spain. LA - eng GR - PID2022-140245OA-I00/Ministerio de Ciencia e Innovacion/ PT - Journal Article DEP - 20260905 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13605130 OTO - NOTNLM OT - ROC curves OT - WHtR-defined cardiometabolic risk OT - Youden index OT - adolescents OT - body composition OT - maturity status OT - physical fitness OT - sex COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/05 CRDT- 2026/09/26 01:07 PHST- 2026/08/09 00:00 [received] PHST- 2026/09/01 00:00 [revised] PHST- 2026/09/03 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:07 [entrez] PHST- 2026/09/05 00:00 [pmc-release] AID - children13091201 [pii] AID - children-13-01201 [pii] AID - 10.3390/children13091201 [doi] PST - epublish SO - Children (Basel). 2026 Sep 5;13(9):1201. doi: 10.3390/children13091201. PMID- 42794149 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260929 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 9 DP - 2026 Aug 24 TI - Associations Between 24-Hour Movement Behaviors and Anthropometric and Body Composition Indicators in Ecuadorian Preschool Children: SUNRISE Pilot Study. LID - 10.3390/children13091129 [doi] LID - 1129 AB - OBJECTIVE: To analyze associations between 24-hour movement behaviors (and guideline adherence) and anthropometric and body composition indicators in Ecuadorian preschoolers using data from the International Study of Movement Behaviors in the Early Years (SUNRISE) pilot study. METHODS: This secondary analysis utilized data from the primary study conducted in 108 children aged 3-4 years (57.4% girls; 50.9% urban). Anthropometry (weight, height, and body mass index [BMI]) was assessed using standardized protocols during the pilot study, whereas body composition indicators (fat-free mass [FFM], fat mass [FM], and body fat percentage) were estimated using a validated anthropometric prediction equation. Movement behaviors were assessed via triaxial accelerometry (ActiGraph GT3X+ or GT3X-BT, Pensacola, FL, USA) over seven days, complemented by parent-reported questionnaires. Exploratory unadjusted correlation analyses were performed using Spearman's rho (rho) for continuous/ordinal variables, and Pearson's correlations (r), mathematically equivalent to point-biserial correlations (r(pb)), for dichotomous-continuous associations. RESULTS: In exploratory unadjusted analyses, device-measured longer sleep duration showed small-to-moderate inverse associations with weight (rho = -0.33, p = 0.001), BMI (rho = -0.28, p = 0.006), and FFM (rho = -0.37, p < 0.001). Higher moderate-to-vigorous physical activity showed moderate positive associations with height (rho = 0.32, p = 0.002), weight (rho = 0.40, p < 0.001), and FFM (rho = 0.44, p < 0.001). In complementary multivariable models, the associations between device-measured sleep or moderate-to-vigorous physical activity (MVPA) and the pre-specified anthropometric and body composition outcomes were attenuated after adjustment for age, sex, area of residence, and, where applicable, height, and were generally not statistically significant. CONCLUSIONS: In this exploratory secondary analysis of the SUNRISE Pilot Study Ecuador, unadjusted analyses identified associations between specific 24-hour movement behaviors, particularly sleep duration and MVPA, and anthropometric and body composition indicators. However, these associations were attenuated after covariate adjustment. The findings should therefore be interpreted as hypothesis-generating and require confirmation in larger longitudinal studies. FAU - Cisneros-Vasquez, Emily AU - Cisneros-Vasquez E AD - School of Medicine, Universidad Espiritu Santo, Samborondon 0901952, Ecuador. AD - Department of Health Research, Icen Cognis, 38370 La Matanza de Acentejo, Spain. FAU - Jimenez-Lopez, Estela AU - Jimenez-Lopez E AUID- ORCID: 0000-0001-8553-7701 AD - Health and Social Research Center, Universidad de Castilla-La Mancha, 13071 Cuenca, Spain. AD - Department of Nursing, University of Castilla-La Mancha, 13071 Cuenca, Spain. FAU - Yanez-Sepulveda, Rodrigo AU - Yanez-Sepulveda R AUID- ORCID: 0000-0002-9311-6576 AD - Faculty of Education and Social Sciences, Universidad Andres Bello, Vina del Mar 8370035, Chile. FAU - Gutierrez-Espinoza, Hector AU - Gutierrez-Espinoza H AUID- ORCID: 0000-0002-4650-3426 AD - Faculty of Education, Universidad Autonoma de Chile, Santiago 7500912, Chile. FAU - Olivares-Arancibia, Jorge AU - Olivares-Arancibia J AD - AFySE Group, Research in Physical Activity and School Health, School of Physical Education, Faculty of Education, Universidad de las Americas, Santiago 7500975, Chile. FAU - Sanchez-Miguel, Pedro Antonio AU - Sanchez-Miguel PA AUID- ORCID: 0000-0002-1660-535X AD - Departamento de Didactica de la Expresion Musical, Plastica y Corporal, Grupo de Investigacion Analisis Didactico y Comportamental del Deporte (ADICODE), Facultad de Formacion del Profesorado, Universidad de Extremadura, 10003 Caceres, Spain. FAU - Rahmati, Masoud AU - Rahmati M AD - CEReSS-Health Service Research and Quality of Life Center, Aix-Marseille University, 13284 Marseille, France. AD - Clinical Research Unit, Delegation a la Recherche Clinique et a l'Innovation du GHT, Center Hospitalier Intercommunal de Toulon La Seyne-sur-Mer, 83100 Toulon, France. FAU - Yon, Dong Keon AU - Yon DK AUID- ORCID: 0000-0003-1628-9948 AD - Center for Digital Health, Medical Science Research Institute, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea. AD - Department of Precision Medicine, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea. AD - Department of Pediatrics, Kyung Hee University Medical Center, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea. FAU - Smith, Lee AU - Smith L AUID- ORCID: 0000-0002-5340-9833 AD - Centre for Health Performance and Wellbeing, Anglia Ruskin University, Cambridge CB1 1PT, UK. AD - Department of Public Health, Faculty of Medicine, Biruni University, Istanbul 34015, Turkey. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AUID- ORCID: 0000-0002-7412-7624 AD - School of Medicine, Universidad Espiritu Santo, Samborondon 0901952, Ecuador. AD - Faculty of Health Sciences, Universidad Tecnologica Atlantico Mediterraneo-UTAMED, 29590 Malaga, Spain. LA - eng GR - 2025-MED-009/Universidad Espiritu Santo/ PT - Journal Article DEP - 20260824 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13605536 OTO - NOTNLM OT - Ecuador OT - childhood OT - daily movement behaviors OT - obesity OT - physical activity OT - screen time OT - sleep COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/08/24 CRDT- 2026/09/26 01:06 PHST- 2026/07/14 00:00 [received] PHST- 2026/08/14 00:00 [revised] PHST- 2026/08/14 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:06 [entrez] PHST- 2026/08/24 00:00 [pmc-release] AID - children13091129 [pii] AID - children-13-01129 [pii] AID - 10.3390/children13091129 [doi] PST - epublish SO - Children (Basel). 2026 Aug 24;13(9):1129. doi: 10.3390/children13091129. PMID- 42793457 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260929 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 18 DP - 2026 Sep 9 TI - Anthropometric Status, Menstrual Health, and Psychosocial Correlates Among 4251 Adolescent Girls in Kazakhstan: A School-Based Cross-Sectional Study. LID - 10.3390/healthcare14182918 [doi] LID - 2918 AB - BACKGROUND/OBJECTIVES: Menstrual health in adolescence is influenced by nutritional, developmental, and psychosocial factors, yet integrated school-based evidence from Central Asia is limited. We assessed recorded anthropometric, menstrual/reproductive, and psychosocial indicators among adolescent girls in southern Kazakhstan and evaluated factors associated with a prespecified composite menstrual/reproductive outcome. METHODS: We conducted a cross-sectional secondary analysis of a non-public school health screening database containing 5197 participant records from 2025. After removal of 946 exact duplicate copies, 4251 unique records of girls aged 12-18 years remained. We present prevalence estimates with Wilson 95% confidence intervals (CIs). We estimated adjusted prevalence ratios (aPRs) using modified Poisson regression with robust standard errors clustered by recorded school field. RESULTS: Mean age was 15.03 +/- 1.23 years and mean BMI was 20.36 +/- 3.36 kg/m(2). The source form used fixed adult BMI categories; these are reported descriptively and are not interpreted as pediatric nutritional diagnoses. At least one non-reference menstrual or reproductive indicator was recorded in 24.1% of participants; severe menstrual pain and stress were each recorded in 6.9%. Stress was associated with any menstrual/reproductive abnormality (aPR 2.05, 95% CI 1.65-2.54) and with severe menstrual pain (aPR 3.27, 95% CI 2.39-4.46). Unsatisfactory nutrition was also associated with the composite outcome (aPR 1.64, 95% CI 1.35-2.00). CONCLUSIONS: Recorded menstrual/reproductive concerns were frequent in this screened sample, and stress showed consistent associations with menstrual outcomes. Because anthropometric categories were based on adult cut points and several screening items were not validated instruments, interpret the findings as descriptive and hypothesis-generating rather than as population prevalence or causal estimates. FAU - Ayazbekov, Ardak AU - Ayazbekov A AD - Scientific Center of Obstetrics, Gynecology and Perinatology, 125 Dostyk Ave., 050010 Almaty, Kazakhstan. FAU - Terlikbayeva, Aigul AU - Terlikbayeva A AD - Scientific Center of Obstetrics, Gynecology and Perinatology, 125 Dostyk Ave., 050010 Almaty, Kazakhstan. FAU - Khaidarov, Saken AU - Khaidarov S AUID- ORCID: 0000-0001-7770-8427 AD - Scientific Center of Obstetrics, Gynecology and Perinatology, 125 Dostyk Ave., 050010 Almaty, Kazakhstan. AD - Department of Molecular Biology and Medical Genetics, Asfendiyarov Kazakh National Medical University, 37A Zheltoksan Street, 050004 Almaty, Kazakhstan. FAU - Baigazieva, Gulzhan AU - Baigazieva G AUID- ORCID: 0000-0003-1724-8419 AD - Scientific Center of Obstetrics, Gynecology and Perinatology, 125 Dostyk Ave., 050010 Almaty, Kazakhstan. FAU - Imanbaeva, Zhaysan AU - Imanbaeva Z AUID- ORCID: 0000-0003-4764-8149 AD - Scientific Center of Obstetrics, Gynecology and Perinatology, 125 Dostyk Ave., 050010 Almaty, Kazakhstan. FAU - Aimbetova, Aliya AU - Aimbetova A AD - Scientific Center of Obstetrics, Gynecology and Perinatology, 125 Dostyk Ave., 050010 Almaty, Kazakhstan. FAU - Kurmanova, Almagul AU - Kurmanova A AUID- ORCID: 0000-0002-1859-3903 AD - Faculty of Medicine and Healthcare, Al-Farabi Kazakh National University, 71 Al-Farabi Ave., 050040 Almaty, Kazakhstan. FAU - Salimbayeva, Damilya AU - Salimbayeva D AUID- ORCID: 0000-0002-7933-3654 AD - Scientific Center of Obstetrics, Gynecology and Perinatology, 125 Dostyk Ave., 050010 Almaty, Kazakhstan. LA - eng GR - BR27308739/Ministry of Health/ PT - Journal Article DEP - 20260909 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13606384 OTO - NOTNLM OT - Kazakhstan OT - adolescent health OT - body mass index OT - cross-sectional studies OT - dysmenorrhea OT - menstrual health OT - nutrition OT - psychosocial stress OT - school health services OT - underweight COIS- The authors declare no conflicts of interest. The funders had no role in the study design; data collection, analysis, or interpretation; manuscript preparation; or the decision to publish the results. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/09 CRDT- 2026/09/26 01:04 PHST- 2026/08/01 00:00 [received] PHST- 2026/08/27 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:04 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - healthcare14182918 [pii] AID - healthcare-14-02918 [pii] AID - 10.3390/healthcare14182918 [doi] PST - epublish SO - Healthcare (Basel). 2026 Sep 9;14(18):2918. doi: 10.3390/healthcare14182918. PMID- 42792471 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260929 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 9 DP - 2026 Sep 17 TI - Psychometric Properties of the French Version of the Physical Literacy Self-Description (PLSD) Questionnaire Among Children. LID - 10.3390/bs16091672 [doi] LID - 1672 AB - This study sought to document the psychometric properties of scores on the French Version of the Physical Literacy Self-Description questionnaire. A sample of 191 French-speaking Canadian and French children, aged 5-12 years, participated in this study. Results from an exploratory factor analytic solution supported a two-factor solution encompassing (a) perceived confidence and value; and (b) perceived skills competence. Subsequent analyses supported the weak, strong and strict invariance of this solution as a function of sex, and its weak, strong, and partial strict invariance (one item was less reliable in France) across countries. The results also revealed meaningful differences in terms of latent variances (showing more inter-individual variability in Canada and among boys) and covariances (showing stronger correlations in France and among boys) across grouping variables. Results further revealed a lack of differential item functioning as a function of age and time spent in moderate to vigorous physical activities, but minimal evidence of differential item functioning as a function of body mass index (on two items). Moreover, Canadian children scored higher on perceived confidence and value and lower on perceived skills competence, while younger children scored higher on perceived skills competence. Likewise, children spending more time in moderate physical activity scored higher in the perceived confidence and value factor, while those spending more time in vigorous physical activity scored higher on the perceived skills competence factor. Finally, results supported the convergent validity of scores obtained on the French Physical Literacy Self-Description questionnaire in relation to parental ratings of children's overall, cognitive, and motor physical literacy. FAU - Maiano, Christophe AU - Maiano C AUID- ORCID: 0000-0002-4764-2209 AD - Department of Psychoeducation and Psychology, Universite du Quebec en Outaouais, Saint-Jerome, QC J7Z 0B7, Canada. AD - Cyberpsychology Laboratory, Department of Psychoeducation and Psychology, Universite du Quebec en Outaouais, Gatineau, QC J8X 3X7, Canada. AD - Substantive-Methodological Synergy Research Laboratory, Department of Psychology, Concordia University, Montreal, QC H4B 1R6, Canada. FAU - Morin, Alexandre J S AU - Morin AJS AUID- ORCID: 0000-0001-6898-4788 AD - Substantive-Methodological Synergy Research Laboratory, Department of Psychology, Concordia University, Montreal, QC H4B 1R6, Canada. AD - Optentia Research Unit, North-West University, P.O. Box 1174, Vanderbijlpark 1900, South Africa. FAU - April, Johanne AU - April J AD - Department of Educational Sciences, Universite du Quebec en Outaouais, Saint-Jerome, QC J7Z 0B7, Canada. FAU - Hue, Olivier AU - Hue O AUID- ORCID: 0000-0001-9270-5291 AD - Department of Physical Activity Sciences, Universite du Quebec a Trois-Rivieres, Trois-Rivieres, QC G9A 5H7, Canada. FAU - Rey, Olivier AU - Rey O AD - ISM, CNRS, Aix Marseille University, 13288 Marseille Cedex 09, France. LA - eng GR - 633-2022-00060/Social Sciences and Humanities Research Council/ PT - Journal Article DEP - 20260917 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13603781 OTO - NOTNLM OT - French OT - cross-sectional validation study OT - differential item functioning OT - exploratory factor analyses OT - measurement invariance OT - physical activity OT - physical literacy COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/17 CRDT- 2026/09/26 01:01 PHST- 2026/06/29 00:00 [received] PHST- 2026/09/07 00:00 [revised] PHST- 2026/09/10 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:01 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - bs16091672 [pii] AID - behavsci-16-01672 [pii] AID - 10.3390/bs16091672 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Sep 17;16(9):1672. doi: 10.3390/bs16091672. PMID- 42791031 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260929 IS - 1746-1561 (Electronic) IS - 0022-4391 (Linking) VI - 96 IP - 10 DP - 2026 Oct TI - Estimating VO(2)max With the Timed Mile Run: An Updated Equation for Today's Youth. PG - e70246 LID - 10.1111/josh.70246 [doi] AB - BACKGROUND: School-based physical fitness testing (SB-PFT) is an important tool to address youth physical inactivity. However, the widely used Fitnessgram equation that converts timed mile run performance into estimates of cardiorespiratory fitness (VO(2)max) may not be valid for today's diverse US adolescent population. This study evaluated its validity, developed updated prediction equations, and examined the effect of omitting sex and/or BMI. METHODS: A diverse sample of middle school students (n = 177) provided demographic information and timed mile run data and completed lab-based VO(2)max testing. Prediction accuracy for the Fitnessgram equation and newly-developed equations was assessed using root mean square error (RMSE), Pearson's correlation, and sensitivity and specificity. RESULTS: In this diverse sample, all four new VO(2)max prediction equations outperformed the Fitnessgram equation, including equations excluding sex and/or BMI. IMPLICATIONS FOR SCHOOL HEALTH POLICY, PRACTICE, AND EQUITY: When evaluated on a diverse sample of adolescents, the Fitnessgram misclassifies many adolescents as being in the healthy fitness zone despite having cardiorespiratory fitness levels associated with elevated health risk. CONCLUSIONS: The Fitnessgram VO(2)max prediction equation should be updated to reflect contemporary US demographics and schools' concerns about collecting BMI data. CI - (c) 2026 American School Health Association. FAU - Gao, Lynn AU - Gao L AUID- ORCID: 0000-0002-3527-5130 AD - Department of Statistics, University of California, Irvine, California, USA. FAU - Berrocal, Veronica AU - Berrocal V AUID- ORCID: 0000-0003-0304-7202 AD - Department of Statistics, University of California, Irvine, California, USA. FAU - Woodworth, Amanda AU - Woodworth A AUID- ORCID: 0000-0003-4055-4625 AD - Institute for Clinical and Translational Science, University of California, Irvine, California, USA. FAU - Thompson, Hannah R AU - Thompson HR AUID- ORCID: 0000-0003-0214-5003 AD - Nutrition Policy Institute, University of California Agriculture and Natural Resources, Berkeley, California, USA. AD - Department of Community Health Sciences, University of California, Berkeley, California, USA. FAU - Schneider, Margaret AU - Schneider M AD - Institute for Clinical and Translational Science, University of California, Irvine, California, USA. AD - Department of Population Health and Disease Prevention, University of California, Irvine, California, USA. LA - eng PT - Journal Article PL - United States TA - J Sch Health JT - The Journal of school health JID - 0376370 SB - IM MH - Humans MH - Adolescent MH - Female MH - *Oxygen Consumption/physiology MH - *Exercise Test/methods MH - *Cardiorespiratory Fitness/physiology MH - Body Mass Index MH - Male MH - *Running/physiology MH - *Physical Fitness/physiology MH - Child OTO - NOTNLM OT - BMI OT - VO2max prediction equation OT - representative sample OT - school-based physical fitness testing EDAT- 2026/09/25 23:47 MHDA- 2026/09/25 23:48 CRDT- 2026/09/25 21:22 PHST- 2026/08/12 00:00 [revised] PHST- 2026/03/05 00:00 [received] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/09/25 23:48 [medline] PHST- 2026/09/25 23:47 [pubmed] PHST- 2026/09/25 21:22 [entrez] AID - 10.1111/josh.70246 [doi] PST - ppublish SO - J Sch Health. 2026 Oct;96(10):e70246. doi: 10.1111/josh.70246. PMID- 42790906 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20261003 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 9 DP - 2026 Sep 25 TI - Adaptation and evaluation of a food preference assessment tool for older adults in geriatric care: the DYSPHAGING Preferences study protocol. PG - e120395 LID - 10.1136/bmjopen-2026-120395 [doi] LID - e120395 AB - INTRODUCTION: Undernutrition is a major concern in older adults due to its multifactorial origins and its impact on morbidity and mortality. Oropharyngeal dysphagia is common in frail geriatric patients and contributes to undernutrition by prompting individuals to progressively withdraw foods from their diet, leading to dietary imbalance and potential complications. Although texture adaptation and nutritional strategies are widely implemented in clinical practice, little is known about the actual food preferences of hospitalised older adults with dysphagia. Existing tools to assess food preferences are scarce and poorly adapted to the heterogeneity and sensory impairments of this population. The DYSPHAGING Preferences study aims to develop a food-preference assessment tool specifically tailored to hospitalised older adults, assess its test-retest reliability and describe food preferences measured using this adapted instrument. METHODS AND ANALYSIS: The DYSPHAGING Preferences study is designed as a prospective, multicentre, non-comparative protocol consisting of three steps. Step 1 will adapt a forced-choice questionnaire-initially developed for paediatric populations-to adults aged>/=70 years hospitalised in geriatric wards, by assessing visual and lexical recognition of pre-selected food items. Step 2 will evaluate the test-retest reliability and practical feasibility of administering the preference questionnaire in a new cohort of older adults. Step 3 will be a cross-sectional study describing food preferences and comparing Preference Indexes between participants screening positive and screening negative for dysphagia using the Eating Assessment Tool-10. The questionnaire will include six categories of food (acidic, textured, sweet, in sauce, dairy and cooked). A total of 209 participants will be included across acute geriatric, rehabilitation and long-term care units (35 participants in step 1, 35 participants in step 2 and 174 participants in step 3, with the 35 participants from step 2 included in the step 3 population). Descriptive and comparative analyses will be performed according to a predefined statistical analysis plan. ETHICS AND DISSEMINATION: The study protocol was approved by the Comite de Protection des Personnes (CPP) Ile-de-France III on 11 September 2025 (approval number: 25.02467.000911-2025-A00795-44), in accordance with French legislation. All participants will provide informed non-opposition in accordance with national regulations. The results of the primary and secondary objectives will be disseminated through peer-reviewed publications, conference presentations and communication with clinical stakeholders. TRIAL REGISTRATION NUMBER: NCT05734586. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Masse-Deragon, Nicolas AU - Masse-Deragon N AD - Institut du Vieillissement, Hospices Civils de Lyon, Lyon, France nicolas.masse-deragon@chu-lyon.fr. FAU - Tripoz-Dit-Masson, Stephanie AU - Tripoz-Dit-Masson S AD - CRC Vieillissement Cerveau Fragilite, Hospices Civils de Lyon, Lyon, France. FAU - Grehalle, Coline AU - Grehalle C AD - Speech therapist team - Centre Hospitalier de Pierre Garraud, Hospices Civils de Lyon, Lyon, France. FAU - Subtil, Fabien AU - Subtil F AD - Service de Biostatistique, Hospices Civils de Lyon, Lyon, Auvergne-Rhone-Alpes, France. AD - CNRS, UMR5558, Laboratoire de Biometrie et Biologie Evolutive, Universite Claude Bernard Lyon 1, Villeurbanne, France. FAU - Rouze, Heloise AU - Rouze H AD - Pole de Sante Publique, Hospices Civils de Lyon, Lyon, France. AD - Laboratoire Reshape, Universite Claude Bernard Lyon 1, Lyon, France. FAU - Grilot, Cecile AU - Grilot C AD - Dietitian team - Centre Hospitalier Pierre Garraud, Hospices Civils de Lyon, Lyon, France. FAU - Merazga, Salima AU - Merazga S AD - Direction a la Recherche en Sante, Hospices Civils de Lyon, Lyon, France. FAU - Goldet, Karine AU - Goldet K AD - Centre de Recherche Clinique Vieillissement Cerveau Fragilite - Hopital des Charpennes, Hospices Civils de Lyon, Villeurbanne, France. FAU - Durlach, Olivier AU - Durlach O AD - Institut du Vieillissement, Hospices Civils de Lyon, Lyon, France. FAU - Schir, Sophie AU - Schir S AD - Institut du Vieillissement, Hospices Civils de Lyon, Lyon, France. AD - Geriatric department - Centre Hospitalier Pierre Garraud, Hospices Civils de Lyon, Lyon, France. FAU - Haution-Bitker, Marine AU - Haution-Bitker M AD - Institut du Vieillissement, Hospices Civils de Lyon, Lyon, France. AD - Geriatric department - Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France. FAU - Merdinian, Marion AU - Merdinian M AD - Institut du Vieillissement, Hospices Civils de Lyon, Lyon, France. AD - Geriatric department - Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France. FAU - Falandry, Claire AU - Falandry C AUID- ORCID: 0000-0001-7267-4723 AD - CarMeN Laboratory, Inserm U1060, INRA U1397, Universite Claude Bernard Lyon 1, INSA Lyon, Charles Merieux Medical School, University of Lyon, Oullins, France. AD - Geriatric department - Centre Hospitalier de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France. LA - eng SI - ClinicalTrials.gov/NCT05734586 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260925 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Aged MH - Aged, 80 and over MH - Female MH - Humans MH - Male MH - Cross-Sectional Studies MH - *Deglutition Disorders/diagnosis/psychology MH - *Food Preferences MH - Frail Elderly MH - *Geriatric Assessment/methods MH - Prospective Studies MH - Reproducibility of Results MH - Research Design MH - Surveys and Questionnaires MH - Multicenter Studies as Topic PMC - PMC13630011 OTO - NOTNLM OT - Frail Elderly OT - GERIATRIC MEDICINE OT - NUTRITION & DIETETICS OT - Organisation of health services OT - Protocols & guidelines COIS- Competing interests: NM-D reports financial support was provided by La Societe Francophone de Nutrition Clinique et Metabolisme. CF reports a relationship with Geriamed that includes: speaking and lecture fees. EDAT- 2026/09/25 23:47 MHDA- 2026/09/25 23:48 PMCR- 2026/09/25 CRDT- 2026/09/25 20:43 PHST- 2026/09/25 23:48 [medline] PHST- 2026/09/25 23:47 [pubmed] PHST- 2026/09/25 20:43 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - bmjopen-2026-120395 [pii] AID - 10.1136/bmjopen-2026-120395 [doi] PST - epublish SO - BMJ Open. 2026 Sep 25;16(9):e120395. doi: 10.1136/bmjopen-2026-120395. PMID- 42789770 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20261009 IS - 2368-7959 (Electronic) IS - 2368-7959 (Linking) VI - 13 DP - 2026 Sep 25 TI - Perinatal Mental Health Detection and Prediction Using Mobile Sensing Data: Systematic Review. PG - e101677 LID - 10.2196/101677 [doi] LID - e101677 AB - BACKGROUND: Perinatal mental health disorders affect approximately 20% of pregnant and postpartum individuals, and are associated with substantial maternal and infant morbidity. Traditional assessment relies on infrequent, subjective self-reports. Mobile devices, including smartphones and wearables, offer opportunities for continuous and objective measurement, but evidence on their assessment utility in perinatal populations remains fragmented. OBJECTIVE: This review aimed to examine the application of wearable devices and smartphones for detecting and predicting perinatal mental health outcomes, with emphasis on predictive performance, informative features, and methodological rigor. METHODS: We conducted a systematic review following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines (PROSPERO CRD420251249218). Six databases (PubMed, Web of Science, Scopus, PsycINFO, IEEE Xplore, and ACM Digital Library) were searched initially in January 2026 and supplemented by an amended search in June 2026, with no publication date restrictions. Evidence was synthesized narratively, and the risk of bias was assessed using PROBAST+AI (Prediction Model Risk of Bias Assessment Tool With AI extension). RESULTS: The initial and supplementary searches yielded 1952 unique records after deduplication, of which 10 studies met the inclusion criteria. The included studies covered postpartum depression, prenatal stress, discrete emotions during pregnancy (eg, happiness, anxiety, and sadness), and maternal loneliness. High discrimination metrics were reported for postpartum depression in individual studies, including a multiclass area under the curve of 0.85, a binary area under the curve of 0.871, and an F(1)-score of 0.9872. Heart rate variability, GPS-derived mobility, physical activity, and sleep features were most frequently reported as useful, and their interpretation requires perinatal-specific contextualization. Methodological quality was limited, with 80% (12/15) of PROBAST+AI assessment units rated as having high overall quality concern or risk of bias, mainly due to small samples, limited validation, inadequate handling of missing data, and potential overfitting in the analysis domain. CONCLUSIONS: Mobile sensing shows preliminary potential for perinatal mental health assessment, but current evidence does not yet support clinical screening or decision-making, and independent external validation in perinatal populations is currently lacking. Progress toward clinical utility requires broader mental health outcome coverage, larger longitudinal cohorts, standardized analytical and reporting practices, adoption of modeling approaches better suited to perinatal trajectories, independent external validation, and human-centered monitoring designs. CI - (c) Yifan Sun, Kemeng Che, Tella Lantta, Anna Axelin, Iman Azimi, Pasi Liljeberg. Originally published in JMIR Mental Health (https://mental.jmir.org). FAU - Sun, Yifan AU - Sun Y AUID- ORCID: 0009-0009-1897-0308 AD - Department of Computing, University of Turku, Yliopistonmaki, Turku, Southwest Finland, FI-20014, Finland, 358 0449508020. FAU - Che, Kemeng AU - Che K AUID- ORCID: 0009-0002-3086-6166 AD - Department of Nursing Science, University of Turku, Turku, Southwest Finland, Finland. FAU - Lantta, Tella AU - Lantta T AUID- ORCID: 0000-0001-7715-7573 AD - Department of Nursing Science, University of Turku, Turku, Southwest Finland, Finland. FAU - Axelin, Anna AU - Axelin A AUID- ORCID: 0000-0003-2743-3589 AD - Department of Nursing Science, University of Turku, Turku, Southwest Finland, Finland. FAU - Azimi, Iman AU - Azimi I AUID- ORCID: 0000-0001-5003-299X AD - Department of Computing, University of Turku, Yliopistonmaki, Turku, Southwest Finland, FI-20014, Finland, 358 0449508020. FAU - Liljeberg, Pasi AU - Liljeberg P AUID- ORCID: 0000-0002-9392-3589 AD - Department of Computing, University of Turku, Yliopistonmaki, Turku, Southwest Finland, FI-20014, Finland, 358 0449508020. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260925 PL - Canada TA - JMIR Ment Health JT - JMIR mental health JID - 101658926 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Mental Disorders/diagnosis MH - *Pregnancy Complications/diagnosis MH - *Wearable Electronic Devices MH - Digital Health MH - *Smartphone PMC - PMC13614507 OTO - NOTNLM OT - digital phenotyping OT - machine learning OT - perinatal mental health OT - postpartum depression OT - smartphone sensing OT - systematic review OT - wearable devices COIS- Conflicts of Interest: None declared. EDAT- 2026/09/25 17:33 MHDA- 2026/09/25 17:34 PMCR- 2026/09/25 CRDT- 2026/09/25 14:53 PHST- 2026/05/18 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/09/25 17:34 [medline] PHST- 2026/09/25 17:33 [pubmed] PHST- 2026/09/25 14:53 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - v13i1e101677 [pii] AID - 101677 [pii] AID - 10.2196/101677 [doi] PST - epublish SO - JMIR Ment Health. 2026 Sep 25;13:e101677. doi: 10.2196/101677. PMID- 42789372 OWN - NLM STAT- Publisher LR - 20260925 IS - 1746-1553 (Electronic) IS - 0309-3646 (Linking) DP - 2026 Aug 10 TI - Machine learning-based prediction model for initial correction effect of Cheneau brace in adolescent idiopathic scoliosis. LID - 10.1097/PXR.0000000000000582 [doi] AB - BACKGROUND: Predicting the initial correction rate (ICR) of Cheneau brace treatment for adolescent idiopathic scoliosis (AIS) is critical for personalized therapeutic planning but remains underexplored. This study aims to develop a clinical prediction model for ICR evaluation. METHODS: A retrospective analysis included 391 spinal curves from 310 patients with AIS (since some patients have double curves) from 4 orthotic centers. Key variables encompassed demographics, axial trunk rotation (ATR), Risser sign, curve type (C-shaped/S-shaped), apical location (thoracic/lumbar), and prebrace Cobb angle. ICR was calculated as [(prebrace Cobb - postbrace Cobb)/prebrace Cobb] x 100%, with satisfactory correction defined as ICR >/=50%. Logistic regression and random forest models were trained (70% data) and validated (30%). Feature importance was assessed through mean decrease accuracy (MDA) and Gini (MDG). A nomogram integrated significant predictors. RESULTS: Multivariate analysis identified Risser sign (OR = 0.033, P < 0.001), ATR (OR = 0.853, P < 0.001), curve type (OR = 0.485, P = 0.036), apical location (OR = 5.827, P < 0.001), and BMI (OR = 0.897, P = 0.041) as independent predictors. Random forest confirmed Risser sign as the most influential variable (MDA = 28.07%, MDG = 24.35%), followed by ATR (MDA = 21.99%, MDG = 19.50%). Both models demonstrated high predictive accuracy: logistic regression (AUC = 0.951, accuracy = 0.879) and random forest (AUC = 0.959, accuracy = 0.897). Lumbar curves and C-shaped curves exhibited superior correctability. CONCLUSION: Machine learning models effectively predict Cheneau brace ICR, with Risser sign and ATR angle as primary determinants. The developed nomogram provides a practical tool for pretreatment outcome anticipation, enhancing clinical decision-making in AIS management. CI - Copyright (c) 2026 The Authors. Published by Wolters Kluwer incorporated on behalf of The International Society for Prosthetics and Orthotics. FAU - Li, Kai-Hua AU - Li KH AUID- ORCID: 0000-0001-7543-2324 AD - Institute of Orthopedics, Fengfeng General Hospital of North China Medical & Health Group, Handan, Hebei, China. AD - North China University of Science and Technology, Tangshan, Hebei, China. FAU - Zhang, Li-Ning AU - Zhang LN AD - Department of Medical Radiology, Fengfeng General Hospital of North China Medical & Health Group, Handan, Hebei, China. FAU - Xiong, Hui-Ling AU - Xiong HL AD - Department of Medical Radiology, Fengfeng General Hospital of North China Medical & Health Group, Handan, Hebei, China. FAU - Chen, Bao-Sheng AU - Chen BS AD - Institute of Orthopedics, Fengfeng General Hospital of North China Medical & Health Group, Handan, Hebei, China. FAU - Yi, Li-Sha AU - Yi LS AD - Institute of Nursing, Fengfeng General Hospital of North China Medical & Health Group, Handan, Hebei, China. LA - eng GR - 23422083389/Handan Science and Technology Research and Development Program Project/ PT - Journal Article DEP - 20260810 PL - France TA - Prosthet Orthot Int JT - Prosthetics and orthotics international JID - 7707720 SB - IM OTO - NOTNLM OT - Cheneau brace OT - adolescent idiopathic scoliosis OT - initial correction rate OT - machine learning OT - predictive modeling OT - risser sign EDAT- 2026/09/25 17:33 MHDA- 2026/09/25 17:33 CRDT- 2026/09/25 12:33 PHST- 2025/11/23 00:00 [received] PHST- 2026/05/04 00:00 [accepted] PHST- 2026/09/25 17:33 [medline] PHST- 2026/09/25 17:33 [pubmed] PHST- 2026/09/25 12:33 [entrez] AID - 00006479-990000000-00460 [pii] AID - 10.1097/PXR.0000000000000582 [doi] PST - aheadofprint SO - Prosthet Orthot Int. 2026 Aug 10. doi: 10.1097/PXR.0000000000000582. PMID- 42788574 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260929 IS - 1984-0462 (Electronic) IS - 0103-0582 (Print) IS - 0103-0582 (Linking) VI - 44 DP - 2026 TI - Factors associated with musculoskeletal pain in the spinal column of children and adolescents: a cross-sectional study with network analysis. PG - e2026040 LID - S0103-05822026000101028 [pii] LID - 10.1590/1984-0462/2026/44/2026040 [doi] LID - e2026040 AB - OBJECTIVE: The aim of this study was to analyze the relationship between musculoskeletal spinal pain and individual, behavioral, and contextual factors in children and adolescents. METHODS: A cross-sectional study was conducted with 189 children and adolescents (10-16 years), of both genders, enrolled in public and private schools in Belem, Para, Brazil. Musculoskeletal pain and postural habits were assessed using the Back Pain and Posture Evaluation Instrument for Children and Adolescents, a validated questionnaire for this population. Network analysis using the EBICglasso estimator explored associations between individual (age, gender), behavioral (physical activity in school and leisure contexts), and contextual factors (school type and postural habits related to daily activities and electronic device use) and the presence of neck and low back pain. RESULTS: The prevalence of low back pain was 62.6% and neck pain 65.4%. Low back pain was negatively associated with family history of pain (r=-0.14) and positively associated with female gender (r=0.19) and neck pain (r=0.12). Sitting posture during electronic device use was negatively associated with neck pain (r=-0.19). Gender and age showed higher centrality, indicating greater influence within the network, while physical activity showed a negative influence on pain outcomes. CONCLUSIONS: Musculoskeletal spinal pain was highly prevalent and associated with multiple interrelated factors. Network analysis highlights its multifactorial nature and provides relevant insights into key variables that may guide integrated health promotion and early prevention strategies in pediatric populations. FAU - Gomes, Marcella Veronnica Pereira AU - Gomes MVP AUID- ORCID: 0000-0002-2137-9246 AD - Universidade Federal do Para, Belem, PA, Brazil. FAU - Belem, Ruth Stefany Monteiro AU - Belem RSM AUID- ORCID: 0009-0004-6056-7364 AD - Universidade Federal do Para, Belem, PA, Brazil. FAU - Pantoja, Amanda Vitoria Gomes AU - Pantoja AVG AUID- ORCID: 0009-0009-4507-7670 AD - Universidade Federal do Para, Belem, PA, Brazil. FAU - Costa, Beatriz Dos Santos AU - Costa BDS AUID- ORCID: 0000-0002-5110-4884 AD - Universidade Federal do Para, Belem, PA, Brazil. FAU - Jardim, Naina Yuki Vieira AU - Jardim NYV AUID- ORCID: 0000-0003-3760-3684 AD - Universidade Estadual do Para, Tucurui, PA, Brazil. FAU - Crisp, Alex Harley AU - Crisp AH AUID- ORCID: 0000-0003-4683-9576 AD - Universidade Federal do Para, Belem, PA, Brazil. FAU - Magalhaes, Mauricio Oliveira AU - Magalhaes MO AUID- ORCID: 0000-0002-7857-021X AD - Universidade Federal do Para, Belem, PA, Brazil. LA - eng PT - Journal Article DEP - 20260918 PL - Brazil TA - Rev Paul Pediatr JT - Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo JID - 9109353 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Child MH - Male MH - Adolescent MH - *Musculoskeletal Pain/epidemiology/etiology MH - Prevalence MH - Brazil/epidemiology MH - *Neck Pain/epidemiology/etiology MH - Risk Factors MH - Posture MH - *Low Back Pain/epidemiology/etiology PMC - PMC13588557 EDAT- 2026/09/25 11:45 MHDA- 2026/09/25 11:46 PMCR- 2026/09/18 CRDT- 2026/09/25 10:34 PHST- 2026/02/24 00:00 [received] PHST- 2026/05/13 00:00 [accepted] PHST- 2026/09/25 11:46 [medline] PHST- 2026/09/25 11:45 [pubmed] PHST- 2026/09/25 10:34 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - S0103-05822026000101028 [pii] AID - 10.1590/1984-0462/2026/44/2026040 [doi] PST - epublish SO - Rev Paul Pediatr. 2026 Sep 18;44:e2026040. doi: 10.1590/1984-0462/2026/44/2026040. eCollection 2026. PMID- 42787151 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260926 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Flow in screen-based gamified virtual reality sports: development and validation of a behaviorally anchored proxy rating scale for adolescents with autism spectrum disorder. PG - 1947117 LID - 10.3389/fpubh.2026.1947117 [doi] LID - 1947117 AB - BACKGROUND: Adolescents with autism spectrum disorder (ASD) face substantial barriers to physical activity participation because of motor coordination difficulties, sensory hypersensitivity, and motivational challenges. Screen-based gamified virtual reality (VR) sports have emerged as a promising alternative, with flow identified as a key psychological mechanism underlying their effects. However, alexithymia and atypical interoceptive processing in adolescents with ASD render conventional self-report flow scales inappropriate for this population. This study aimed to develop and validate a behaviorally anchored rating scale (BARS)-format proxy assessment tool, VR-Flow-BARS, that lets observers evaluate the flow-related behaviors of adolescents with ASD during VR sports participation. METHODS: Eighteen preliminary items were developed from flow theory and the theoretical framework underlying the Flow State Scale-2. An eight-member expert panel of specialists in adapted physical education, ASD education, and VR sports evaluated the items against three criteria: content validity, observability, and appropriateness for ASD. The items were refined through cognitive interviews (n = 8) and pilot testing (n = 30). Exploratory factor analysis (EFA) using principal axis factoring with direct oblimin rotation was conducted on Sample 1 (n = 100), followed by confirmatory factor analysis (CFA) on Sample 2 (n = 200). Reliability was assessed using Cronbach's alpha, composite reliability (CR), and the intraclass correlation coefficient (ICC) (2,1). Validity was examined using the average variance extracted (AVE), the Fornell-Larcker criterion, and the heterotrait-monotrait (HTMT) ratio. RESULTS: The expert review yielded an item-level content validity index of 1.00 and a scale-level content validity index of 1.00 across all three criteria for the 15 retained items; the factor "sensorimotor flow expression" (with three items) was deleted for conceptual overlap and limited observability. EFA identified a five-factor structure accounting for 68.394% of the total variance. CFA demonstrated acceptable model fit (chi (2)/df = 2.000, comparative fit index = 0.969, Tucker-Lewis index = 0.959, root mean square error of approximation = 0.071), with standardized factor loadings ranging from 0.763 to 0.940. Internal consistency was high (Cronbach's alpha = 0.864-0.946; CR = 0.868-0.946). Inter-rater reliability (ICC) ranged from 0.729 to 0.910 (indicating moderate to excellent reliability). AVE values ranged from 0.687 to 0.854, satisfying the convergent validity criterion of 0.50, and HTMT values for all factor pairs were below 0.90 at the point-estimate level; however, the 95% bootstrap confidence interval for the FR-CEP pair [0.851, 0.939] extended beyond 0.90, indicating borderline discriminant validity for this factor pair. CONCLUSION: To our knowledge, VR-Flow-BARS tool is the first BARS-format proxy assessment instrument developed to evaluate flow-related behaviors in adolescents with ASD during screen-based gamified VR sports. It demonstrates an acceptable factor structure, high internal consistency, adequate inter-rater reliability, and internal structural validity. This scale may serve as a practical tool for the real-time monitoring of immersive behaviors and individualized intervention design in VR-based physical activity programs for adolescents with ASD who have mild-to-moderate educational support needs and are able to engage in VR tasks with routine prompting. Future research should address external criterion-based validation, test-retest reliability, and applicability across a broader range of ASD severity levels. CI - Copyright (c) 2026 Oh and Kwon. FAU - Oh, Ahra AU - Oh A AD - Institute of Sport Science, Korea National Sport University, Seoul, Songpa-gu, Republic of Korea. FAU - Kwon, Daekeun AU - Kwon D AD - Institute of Sports Health Science, Sunmoon University, Chungnam, Asan, Republic of Korea. LA - eng PT - Journal Article PT - Validation Study DEP - 20260910 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Autism Spectrum Disorder/psychology MH - Adolescent MH - *Virtual Reality MH - Male MH - Female MH - *Sports/psychology MH - Reproducibility of Results MH - *Video Games/psychology PMC - PMC13600849 OTO - NOTNLM OT - adapted physical activity OT - adolescents with autism spectrum disorder OT - behaviorally anchored rating scale flow OT - gamification OT - proxy assessment OT - scale development OT - screen-based virtual reality sports COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/25 11:45 MHDA- 2026/09/25 11:46 PMCR- 2026/09/10 CRDT- 2026/09/25 06:01 PHST- 2026/07/24 00:00 [received] PHST- 2026/08/23 00:00 [revised] PHST- 2026/08/30 00:00 [accepted] PHST- 2026/09/25 11:46 [medline] PHST- 2026/09/25 11:45 [pubmed] PHST- 2026/09/25 06:01 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1947117 [doi] PST - epublish SO - Front Public Health. 2026 Sep 10;14:1947117. doi: 10.3389/fpubh.2026.1947117. eCollection 2026. PMID- 42787127 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260926 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Structured environmental cues and youth sports consumption: an AI-powered behavioral modeling approach. PG - 1916559 LID - 10.3389/fpubh.2026.1916559 [doi] LID - 1916559 AB - INTRODUCTION: Physical inactivity among children and adolescents represents a critical global public health challenge, imposing an annual economic burden exceeding $27 billion on healthcare systems worldwide. Despite this pressing concern, the complex, cross-level relationships between structured environmental cues-spanning household, school, and community domains-and youth sports consumption remain inadequately understood, particularly across the heterogeneous urbanrural continuum characteristic of rapidly developing economies. METHODS: This study employed a longitudinal survey (China Health and Nutrition Survey, CHNS) comprising 4,240 child-wave observations nested within 940 households and 182 communities. We benchmarked conventional multilevel regression against three machine learning approaches-gradient boosting, random forest, and LSTM sequence models-using temporal and spatial holdout validation. Feature-level and interaction-level interpretability was recovered via SHAP decomposition to quantify the magnitude and breakdown of urbanrural interplay in multi-layered environmental factors shaping youth sport consumption. RESULTS: The gradient boosting model significantly outperformed the multilevel baseline, achieving a holdout R (2) of 0.49 versus 0.31 (RMSE = 1.08 vs. 1.42, p < 0.001), representing a 0.18 R (2) unit improvement. Community recreational infrastructure emerged as the most influential predictor (mean |SHAP| = 0.42). SHAP dependence analysis revealed a compensatory pattern wherein the marginal predicted contribution of community infrastructure was three times greater for low-income households (0.181) compared to high-income households (0.046). School-based physical education provision demonstrated stronger effects among younger adolescents (mean |SHAP| = 0.39 vs. 0.22), with a thresholdpeak urbanization effect identified at index level 40 for rural communities. DISCUSSION: This study provides novel evidence that public space recreation infrastructure yields substantially greater behavioral returns in resource-limited communities, challenging assumptions that uniform investment strategies are optimal across socioeconomic strata. The findings offer a new methodological and intervention paradigm for promoting youth physical activity in socioeconomically diverse, rapidly urbanizing regions, emphasizing targeted infrastructure investment in disadvantaged communities as a high-return public health strategy. CI - Copyright (c) 2026 Cheng and Zhao. FAU - Cheng, Xingyu AU - Cheng X AD - Capital University of Physical Education and Sports, Beijing, China. FAU - Zhao, Jin AU - Zhao J AD - School of Physical Education, Jiangsu Normal University, Jiangsu, China. LA - eng PT - Journal Article DEP - 20260910 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Adolescent MH - Longitudinal Studies MH - Child MH - *Youth Sports/statistics & numerical data MH - Female MH - Male MH - *Cues MH - *Artificial Intelligence MH - Boosting Machine Learning Algorithms MH - Environment MH - Nutrition Surveys PMC - PMC13600879 OTO - NOTNLM OT - China health and nutrition survey OT - built environment OT - gradient boosting OT - machine learning interpretability OT - multilevel modeling OT - structured environmental cues OT - youth sports consumption COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/25 11:45 MHDA- 2026/09/25 11:46 PMCR- 2026/09/10 CRDT- 2026/09/25 05:51 PHST- 2026/06/22 00:00 [received] PHST- 2026/08/15 00:00 [revised] PHST- 2026/08/21 00:00 [accepted] PHST- 2026/09/25 11:46 [medline] PHST- 2026/09/25 11:45 [pubmed] PHST- 2026/09/25 05:51 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1916559 [doi] PST - epublish SO - Front Public Health. 2026 Sep 10;14:1916559. doi: 10.3389/fpubh.2026.1916559. eCollection 2026. PMID- 42786849 OWN - NLM STAT- Publisher LR - 20260925 IS - 1875-6190 (Electronic) IS - 1570-159X (Linking) DP - 2026 Sep 21 TI - Clinical Predictors of Lithium Response in Patients with Bipolar Disorder: Potential Predictive Role of Chronotype, Rumination and Traumatic Events. LID - 10.2174/011570159X482667260909062619 [doi] AB - INTRODUCTION: Bipolar Disorders (BD) are severe, recurrent, and well-characterized psychiatric conditions with lithium as the first-line approved treatment for BD. This study aims to evaluate lithium response using the ALDA scale and to identify reliable predictors in a cohort of patients with BD. METHODS: In this cross-sectional observational study, one hundred and fourteen consecutively recruited patients with a primary diagnosis of BD type I or II were included between June 2022 and June 2025. Sociodemographic and clinical characteristics were collected through a semi-structured interview. Lithium response was retrospectively assessed using the ALDA scale. Psychometric instruments (CTQ, MEQ, MWQ, DDFS, RRS, BIS-11) were administered. Logistic regression analyses were performed to identify independent predictors of lithium response. RESULTS: Forty-one (36%) individuals were classified as lithium responders according to the ALDA Scale. Lithium responders were younger, engaged in physical activity more frequently, were more frequently diagnosed with BD type II, had a shorter illness duration, a Manic-Depressive-Interval (MDI) course, and showed fewer residual symptoms. Non-responders were associated with rapid cycling, psychotic symptoms, more hospitalizations, and illicit substance use. Childhood trauma, impulsivity, and rumination were more common among non-responders, while morning chronotype was more prevalent among responders. In the regression analysis, the MDI pattern, higher total scores for attentional impulsivity and rumination, and morning chronotype were all significantly associated with lithium responsiveness. On the other hand, the presence of psychotic symptoms, a history of >/= 5 hospitalizations, comorbid substance use, and higher scores of emotional abuse were associated with a lower likelihood of response to lithium. DISCUSSION: Integrating the evaluation of trauma history, impulsive profiles, ruminative tendencies, and circadian features into clinical assessment may enhance the prediction of lithium response. CONCLUSION: Our findings support the development of personalized treatment strategies for BD. CI - Copyright(c) Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. FAU - Aguglia, Andrea AU - Aguglia A AUID- ORCID: 0000-0002-2003-2101 AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. AD - IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy. FAU - Breda, Giulia Silvia AU - Breda GS AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. FAU - Aprile, Valentina AU - Aprile V AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. FAU - Gagliardi, Michela AU - Gagliardi M AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. FAU - Stefanini, Francesco AU - Stefanini F AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. FAU - Conio, Benedetta AU - Conio B AUID- ORCID: 0000-0002-8201-7193 AD - IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy. FAU - Costanza, Alessandra AU - Costanza A AUID- ORCID: 0000-0001-6387-6462 AD - Department of Psychiatry, Faculty of Medicine, Geneva University (UNIGE), 1205 Geneva, Switzerland. AD - Department of Psychiatry, Faculty of Biomedical Sciences, University of Italian Switzerland (USI), 6900 Lugano, Switzerland. FAU - Amore, Mario AU - Amore M AUID- ORCID: 0000-0003-2927-2192 AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. FAU - Amerio, Andrea AU - Amerio A AUID- ORCID: 0000-0002-3439-340X AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. AD - IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy. FAU - Serafini, Gianluca AU - Serafini G AUID- ORCID: 0000-0002-6631-856X AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. AD - IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy. LA - eng PT - Journal Article DEP - 20260921 PL - United Arab Emirates TA - Curr Neuropharmacol JT - Current neuropharmacology JID - 101157239 SB - IM OTO - NOTNLM OT - Bipolar disorder OT - bipolar cycle OT - chronotype OT - lithium OT - rumination OT - trauma EDAT- 2026/09/25 05:31 MHDA- 2026/09/25 05:31 CRDT- 2026/09/25 02:56 PHST- 2026/02/27 00:00 [received] PHST- 2026/06/19 00:00 [revised] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/09/25 05:31 [medline] PHST- 2026/09/25 05:31 [pubmed] PHST- 2026/09/25 02:56 [entrez] AID - CN-EPUB-158554 [pii] AID - 10.2174/011570159X482667260909062619 [doi] PST - aheadofprint SO - Curr Neuropharmacol. 2026 Sep 21. doi: 10.2174/011570159X482667260909062619. PMID- 42786460 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260926 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Sep 3 TI - Combined use of the pediatric Yorkhill malnutrition score and mid-upper arm circumference for identifying nutritional risk and predicting length of hospital stay in hospitalized children: a pilot study. LID - 10.1186/s12887-026-07609-5 [doi] LID - 905 AB - BACKGROUND: Childhood malnutrition remains a critical public health challenge among hospitalized pediatric populations, contributing to increased morbidity and prolonged length of hospital stay (LOS). In countries undergoing nutritional transition, such as Turkiye, the "double burden of malnutrition"-characterized by the coexistence of undernutrition and obesity-is exacerbated by socio-economic inequities. This study aimed to assess the prevalence and risk factors of malnutrition in hospitalized children and to evaluate the predictive validity of two rapid screening tools: the Pediatric Yorkhill Malnutrition Score (PYMS) and mid-upper arm circumference (MUAC), with attention to their utility in identifying socio-economic vulnerability. METHODS: This pilot study was conducted between January and July 2024 in a tertiary university hospital in Turkiye. A total of 100 children (50 girls, 50 boys), aged 1 month to 18 years, were evaluated. Nutritional status was assessed using World Health Organization (WHO) anthropometric Z-scores. Malnutrition risk was screened via PYMS and age-adjusted MUAC Z-scores. A novel socio-economic malnutrition risk classification was developed based on household income, family size, and maternal employment status. This pilot study tested the combined use of routine anthropometric measurements and practical screening tools such as PYMS and MUAC for a later large-scale, school-based screening. RESULTS: The double burden of malnutrition was evident: 13.0% had acute malnutrition and 11.0% chronic malnutrition (stunting); among children aged 5-18 years, 34.5% were overweight and 21.8% obese. The LOS was significantly longer in the PYMS high-risk group compared to the low-risk group (p = 0.001), and in the MUAC moderate malnutrition group (p < 0.05). PYMS demonstrated high specificity (95.89%) for acute malnutrition but limited sensitivity for stunting. Among children aged > 5 years, MUAC Z-scores correlated significantly with body mass index (BMI) Z-scores (p < 0.05). Children classified as high-risk by the socio-economic model had significantly lower height-for-age Z-scores (p < 0.05). CONCLUSIONS: This study highlights the impact of socio-economic inequities-such as low income and household overcrowding-on chronic malnutrition and confirms the clinical relevance of the double burden of malnutrition. PYMS and MUAC effectively predict prolonged hospitalization and adverse clinical outcomes. The integration of socio-economic risk assessment with routine malnutrition screening may guide equitable resource allocation and improve care for vulnerable pediatric populations. CI - (c) 2026. The Author(s). FAU - Celik, Emre AU - Celik E AD - Department of Pediatrics, Bursa City Training and Research Hospital, Bursa, Turkiye. abdullahemrecelik@gmail.com. FAU - Korkmaz, Muhammet Furkan AU - Korkmaz MF AD - Department of Pediatrics, Bursa City Training and Research Hospital, Bursa, Turkiye. FAU - Ozkaya, Yunus AU - Ozkaya Y AD - Department of Public Health, Sirnak Provincial Health Directorate, Sirnak, Turkiye. FAU - Yuce, Servet AU - Yuce S AD - Department of Public Health, Istanbul Provincial Health Directorate, Istanbul, Turkiye. FAU - Soyubelli, Tugce Dilara AU - Soyubelli TD AD - Department of Pediatrics, Bursa City Training and Research Hospital, Bursa, Turkiye. FAU - Tutanc, Murat AU - Tutanc M AD - Department of Pediatrics, Bursa City Training and Research Hospital, Bursa, Turkiye. LA - eng PT - Journal Article DEP - 20260903 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Female MH - Pilot Projects MH - Child, Preschool MH - Infant MH - Male MH - Child MH - *Length of Stay/statistics & numerical data MH - *Arm/anatomy & histology MH - Adolescent MH - Risk Factors MH - *Child Nutrition Disorders/diagnosis/epidemiology MH - Anthropometry MH - Risk Assessment/methods MH - *Nutrition Assessment MH - Child, Hospitalized MH - Prevalence MH - *Malnutrition/diagnosis/epidemiology MH - Nutritional Status MH - Predictive Value of Tests PMC - PMC13602631 OTO - NOTNLM OT - Health inequities OT - Hospitalized children OT - MUAC OT - Mid-upper arm circumference OT - Nutritional screening OT - PYMS OT - Pediatric malnutrition OT - Socio-economic determinants COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Clinical Research Ethics Committee of Bursa City Hospital (Approval No: 2023-20/3). Our study was conducted according to the Declaration of Helsinki, and Informed written and verbal consent was obtained from all participants or their legal guardians. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/25 05:32 MHDA- 2026/09/25 05:33 PMCR- 2026/09/03 CRDT- 2026/09/24 23:57 PHST- 2026/01/19 00:00 [received] PHST- 2026/08/27 00:00 [accepted] PHST- 2026/09/25 05:33 [medline] PHST- 2026/09/25 05:32 [pubmed] PHST- 2026/09/24 23:57 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - 10.1186/s12887-026-07609-5 [pii] AID - 7609 [pii] AID - 10.1186/s12887-026-07609-5 [doi] PST - epublish SO - BMC Pediatr. 2026 Sep 3;26(1):905. doi: 10.1186/s12887-026-07609-5. PMID- 42785732 OWN - NLM STAT- Publisher LR - 20260924 IS - 1461-7021 (Electronic) IS - 1359-1045 (Linking) DP - 2026 Sep 24 TI - Adolescents in the Digital Age: Phubbing, Parental Phubbing, Emotional Eating, and Emotion Regulation Difficulties. PG - 13591045261491778 LID - 10.1177/13591045261491778 [doi] AB - BackgroundParental smartphone use during parent-child interactions, known as parental phubbing, may negatively affect adolescents' emotional well-being and contribute to psychological maltreatment. However, the mechanisms linking parental phubbing to adolescents' own digital behaviors remain unclear.ObjectiveThis study examined the associations among parental phubbing, adolescent phubbing, emotion regulation difficulties, perceived psychological maltreatment, and emotional eating, and investigated the mediating roles of emotion regulation difficulties and psychological maltreatment.MethodsThe sample included 128 adolescents aged 12-17 years (51.6% female) and their parents. Participants completed validated self-report measures assessing phubbing behaviors, emotion regulation difficulties, psychological maltreatment, and emotional eating. Correlation, multiple regression, and mediation analyses were conducted.ResultsAdolescent phubbing was positively associated with maternal and paternal phubbing, emotion regulation difficulties, paternal psychological maltreatment, and emotional eating (all p < .05). Regression analyses showed that paternal phubbing, emotion regulation difficulties, paternal psychological maltreatment, and gender significantly predicted adolescent phubbing, explaining 40% of the variance. Mediation analyses indicated that emotion regulation difficulties mediated the associations between both maternal and paternal phubbing and adolescent phubbing. Paternal psychological maltreatment also partially mediated the relationship between paternal phubbing and adolescent phubbing.ConclusionsParental phubbing, particularly paternal phubbing, may influence adolescents' digital behaviors through emotion regulation difficulties and perceived psychological maltreatment, highlighting the importance of parental digital habits for adolescent well-being. FAU - Avunduk, Serdar AU - Avunduk S AUID- ORCID: 0000-0003-3337-1927 AD - Department of Child and Adolescent Psychiatry Canakkale Mehmet Akif Ersoy State Hospital, Canakkale, Turkey. FAU - Aksoy Avunduk, Sena AU - Aksoy Avunduk S AUID- ORCID: 0000-0002-3909-5188 AD - Faculty of Medicine, Department of Child and Adolescent Psychiatry, Canakkale Onsekiz Mart University, Canakkale, Turkey. RINGGOLD: 52950 FAU - Gavcar, Erdal Gorkem AU - Gavcar EG AD - Faculty of Medicine, Department of Child and Adolescent Psychiatry, Pamukkale University, Denizli, Turkey. RINGGOLD: 52990 LA - eng PT - Journal Article DEP - 20260924 PL - England TA - Clin Child Psychol Psychiatry JT - Clinical child psychology and psychiatry JID - 9604507 SB - IM OAB - What is this study about? In today's digital era, parents often use their smartphones during moments spent with their children-a behavior known as "parental phubbing." This study explored how parents' phone use affects teenagers' own smartphone habits, their ability to manage negative emotions, their perceptions of emotional neglect within the family, and their tendency to engage in emotional eating. What did the researchers do? The researchers surveyed 128 adolescents aged 12 to 17 and their parents at an outpatient clinic. Participants completed questionnaires assessing parental and adolescent smartphone habits, emotion regulation difficulties, feelings of psychological maltreatment, and emotional eating behaviors. What were the key findings? Parental Influence: Teenagers were more likely to phub others if their mothers and fathers frequently used smartphones around them. The Role of Fathers: Father phubbing emerged as a particularly strong factor. Fathers' device distraction directly predicted higher adolescent phubbing and indirect risks linked to emotional dysregulation and perceived paternal emotional neglect. Emotional Dysregulation: Adolescents who struggled to process negative feelings were significantly more likely to use smartphones as an escape and turn to food to cope with distress. Why do these findings matter? This research highlights that parental digital distraction is not just a mild annoyance; it can function as a form of relational distance that undermines an adolescent's emotional well-being. Interventions should encourage device-free family times and help parents-especially fathers-understand the crucial role emotional availability plays in fostering healthy digital and lifestyle habits in youth. OABL- eng OTO - NOTNLM OT - adolescents OT - emotion regulation OT - emotional eating OT - parental phubbing OT - phubbing OT - psychological maltreatment EDAT- 2026/09/24 23:52 MHDA- 2026/09/24 23:52 CRDT- 2026/09/24 19:53 PHST- 2026/09/24 23:52 [medline] PHST- 2026/09/24 23:52 [pubmed] PHST- 2026/09/24 19:53 [entrez] AID - 10.1177/13591045261491778 [doi] PST - aheadofprint SO - Clin Child Psychol Psychiatry. 2026 Sep 24:13591045261491778. doi: 10.1177/13591045261491778. PMID- 42781358 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260924 LR - 20260926 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Advancing early identification of at-risk children: a consensus-based refinement and validation roadmap for the pediatric malnutrition screening algorithm. PG - 1857903 LID - 10.3389/fnut.2026.1857903 [doi] LID - 1857903 AB - INTRODUCTION: Mild malnutrition risk remains an underrecognized yet clinically important contributor to impaired growth and development in children aged 1-10 years across the Middle East. Regional estimates indicate that 15-25% of children in the Gulf Cooperation Council (GCC) fall within the mild malnutrition risk category (Weight-for-Height Z-score [WHZ] between -1 and -2 SD), a subgroup vulnerable to progressive growth faltering yet excluded from conventional malnutrition diagnostic thresholds (WHZ < -2 SD). The Pediatric Malnutrition Screening Algorithm (PMSA-2025) was refined through a structured regional expert consensus process to enable early, standardized detection of these at-risk children in outpatient and community healthcare settings. METHODS: A 14-member multidisciplinary expert panel from different countries (KSA, UAE, Egypt, Kuwait, Oman, Russia, United States, and Turkiye) refined the PMSA-2025 using a three-round, hybrid modified Delphi approach conducted in September 2025. Expert selection criteria included a minimum of 10 years of clinical or academic experience in pediatric nutrition or gastroenterology, active involvement in malnutrition-related clinical practice or research, and representation of diverse regional healthcare contexts. Content validity was assessed using the Item-level Content Validity Index (I-CVI), with a threshold of >/=0.80 for domain retention. Six clinical domains were retained from an initial pool of eight candidate domains after Delphi-based consensus: perinatal history, growth trajectory, prior nutritional diagnosis, hospitalization frequency, infection recurrence, and feeding behavior. Each domain was operationalized with measurable, age-appropriate criteria and incorporated into a binary (Yes/No) scoring system (total score: 0-6). The tool is designed for use by pediatricians, family physicians, nurses, and trained community health workers in children aged 1-10 years with WHZ between -1 and -2 SD. Exclusion criteria include children with primary chronic systemic disease driving growth impairment and those already receiving formal nutritional support. RESULTS: All six retained domains achieved an Item-level CVI (I-CVI) >/= 0.85 in the final consensus round. Two initial candidate domains (dietary diversity score, caregiver nutritional literacy) were excluded due to insufficient agreement (I-CVI < 0.70). Three domains required definitional refinement during Round 2, achieving >/=90% final agreement in Round 3. The PMSA-2025 stratifies mild malnutrition risk across three tiers: low (0-1), moderate (2-3), and high (4-6). It requires no specialized equipment beyond a standard scale and can be completed within routine consultations. CONCLUSION: The PMSA-2025 represents a consensus-based, multidimensional screening tool with established content validity designed to address the unmet need for early mild malnutrition risk identification in outpatient and community pediatric settings across the Middle East. CI - Copyright (c) 2026 Murray, Shaaban, Shamsah, Al Hammadi, Amin, Almehaidib, Elkhashab, Pyrieva, Al Hammadi, Cetin, Al-Said, AlSaadi, Kamal and ElBaroudy. FAU - Murray, Robert D AU - Murray RD AD - Emeritus Professor of Pediatrics, Pediatric GI and Nutrition, The Ohio State University School of Medicine, Columbus, OH, United States. FAU - Shaaban, Sanaa Y AU - Shaaban SY AD - Professor of Pediatrics, Department of Pediatrics, Consultant of Pediatric Clinical Nutrition, Ain Shams University, Cairo, Egypt. FAU - Shamsah, Abdullah AU - Shamsah A AD - President of Kuwait Pediatric Association, Kuwait, Kuwait. AD - Pediatric & Pediatric Emergency Consultant, Ministry of Health, Kuwait, Kuwait. FAU - Al Hammadi, Ahmed AU - Al Hammadi A AD - Dubai Health Authority, Dubai Medical College, Dubai, United Arab Emirates. FAU - Amin, Ahmed AU - Amin A AD - Abbott Laboratories, Dubai, United Arab Emirates. FAU - Almehaidib, Ali AU - Almehaidib A AD - King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. FAU - Elkhashab, Ehab Khairy AU - Elkhashab EK AD - Pediatric Clinical Nutrition Unit, Ain Shams University, Cairo, Egypt. FAU - Pyrieva, Ekaterina A AU - Pyrieva EA AD - Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russia. FAU - Al Hammadi, Entesar AU - Al Hammadi E AD - Dubai Health Authority, Dubai Medical College, Dubai, United Arab Emirates. FAU - Cetin, Funda AU - Cetin F AD - Ege University Faculty of Medicine, Department of Pediatrics, Izmir, Turkiye. FAU - Al-Said, Khoula AU - Al-Said K AD - Department of Paediatric Gastroenterology, Royal Hospital, Muscat, Oman. FAU - AlSaadi, Muslim AU - AlSaadi M AD - Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. FAU - Kamal, Naglaa M AU - Kamal NM AD - Department of Pediatrics and Pediatric Hepatology, Kasr Al-Ainy Faculty of Medicine, Cairo, Egypt. FAU - ElBaroudy, Eslam Tawfik AU - ElBaroudy ET AD - Department of Pediatrics, Faculty of Medicine, University of Suez, Suez, Egypt. AD - Department of Health, Kids Heart Medical Center affiliated Columbia University, Abu Dhabi, United Arab Emirates. LA - eng PT - Journal Article PT - Review DEP - 20260909 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13598915 OTO - NOTNLM OT - Middle East OT - Z-score OT - content validity OT - early detection OT - growth monitoring OT - malnutrition OT - pediatric nutrition OT - screening COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author NK declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/09/24 17:31 MHDA- 2026/09/24 17:32 PMCR- 2026/09/09 CRDT- 2026/09/24 16:19 PHST- 2026/04/16 00:00 [received] PHST- 2026/07/09 00:00 [revised] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/09/24 17:32 [medline] PHST- 2026/09/24 17:31 [pubmed] PHST- 2026/09/24 16:19 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - 10.3389/fnut.2026.1857903 [doi] PST - epublish SO - Front Nutr. 2026 Sep 9;13:1857903. doi: 10.3389/fnut.2026.1857903. eCollection 2026. PMID- 42780328 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260924 LR - 20260925 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Body mass index is positively associated with flatfoot and inversely associated with hindfoot valgus in school-aged children: a cross-sectional analysis of 3,292 screening records. PG - 1930830 LID - 10.3389/fped.2026.1930830 [doi] LID - 1930830 AB - BACKGROUND: A higher body mass index (BMI) has been associated with pediatric flatfoot, but it is unclear whether BMI relates similarly to arch morphology, hallux alignment, and hindfoot alignment when these measures are collected within the same school-screening workflow. Herein, we examined phenotype-specific associations between BMI and three scanner-derived foot measures. METHODS: This secondary cross-sectional analysis linked project-based school foot-screening records to on-site anthropometric measurements. After linkage and quality-control exclusions, 3,292 records from six primary schools were analyzed. Record-level outcomes were moderate-to-severe flatfoot (arch index >/= 0.28), mild hallux valgus (15 degrees to <30 degrees ), and moderate-to-severe hindfoot valgus (>/=4 degrees ), with positivity defined by either foot. BMI was analyzed in sample-specific quartiles and per 1 internal SD. Multivariable binary logistic regression adjusted for age, sex, and school; threshold and duplicate-identifier sensitivity analyses were performed. RESULTS: The 3,292 records represented 3,266 unique school-student identifiers; median age was 10 years (IQR: 9-12), and There were 1,616 female records (49.1%). Screening prevalence was 64.3% for flatfoot, 11.5% for mild hallux valgus, and 52.8% for hindfoot valgus. Each 1-SD higher BMI (4.73 kg/m(2)) was associated with higher odds of flatfoot [odds ratio (OR): 1.37, 95% CI: 1.26-1.49; P < 0.001] and lower odds of hindfoot valgus (OR: 0.82, 95% CI: 0.76-0.88; P < 0.001), while mild hallux valgus showed no statistically significant association (OR: 0.93, 95% CI: 0.82-1.05; P = 0.244). More stringent threshold analyses and analyses retaining one record per identifier produced materially similar BMI associations. CONCLUSIONS: BMI was positively associated with flatfoot and inversely associated with hindfoot valgus, while no significant association was observed for mild hallux valgus. These cross-sectional associations describe operational scanner-derived screening phenotypes and should not be interpreted as causal effects or clinical diagnoses. Prospective studies with documented anthropometric quality control and validated clinical or radiographic measures are needed. CI - (c) 2026 Li, Li, Huo, Xu, Wang, Zhou, Dong, Song, Yang and Wang. FAU - Li, Shanyuan AU - Li S AD - Department of Rehabilitation, Tangshan Second Hospital, Tangshan, Hebei, China. AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Li, Dongmei AU - Li D AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Huo, Yongxin AU - Huo Y AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Xu, Ying AU - Xu Y AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Wang, Yuhang AU - Wang Y AD - Tianjin Delijie Medical Devices Co., Ltd., Tianjin, China. FAU - Zhou, Hongyan AU - Zhou H AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Dong, Xinyang AU - Dong X AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Song, Ying AU - Song Y AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Yang, Weixin AU - Yang W AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Wang, Bin AU - Wang B AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. LA - eng PT - Journal Article DEP - 20260909 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13597771 OTO - NOTNLM OT - body mass index OT - flatfoot OT - hallux valgus OT - hindfoot valgus OT - pediatric orthopedics OT - school screening COIS- YW was employed by Tianjin Delijie Medical Devices Co., Ltd., the manufacturer of the foot analysis instrument used in this study. The remaining author(s) declared that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/24 12:49 MHDA- 2026/09/24 12:50 PMCR- 2026/09/09 CRDT- 2026/09/24 10:58 PHST- 2026/07/07 00:00 [received] PHST- 2026/08/11 00:00 [revised] PHST- 2026/08/13 00:00 [accepted] PHST- 2026/09/24 12:50 [medline] PHST- 2026/09/24 12:49 [pubmed] PHST- 2026/09/24 10:58 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - 10.3389/fped.2026.1930830 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 9;14:1930830. doi: 10.3389/fped.2026.1930830. eCollection 2026. PMID- 42780322 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260924 LR - 20260925 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Temporal changes in gait parameters and muscle activation during sustained walking in children with spastic cerebral palsy. PG - 1865485 LID - 10.3389/fped.2026.1865485 [doi] LID - 1865485 AB - OBJECTIVE: Temporal changes in spatiotemporal gait parameters and muscle activation may reflect progressive gait deterioration during prolonged walking in children with spastic cerebral palsy. METHODS: A portable gait analysis system and surface electromyography were used to evaluate gait characteristics during a 3-minute walking protocol in 15 children with SCP and 15 age-matched healthy controls. Participants walked at a self-selected speed on a level surface. Spatiotemporal gait parameters, energy expenditure, and bilateral gastrocnemius and tibialis anterior muscle activation were assessed at predefined time points. Linear mixed-effects models were applied to examine group-by-time interactions while accounting for repeated measurements within participants. RESULTS: Linear mixed-effects model analysis revealed significant Group x Time interactions for stance phase, swing phase, step length, lower-limb forward acceleration, foot clearance angle, and walking velocity (all P < 0.05), indicating divergent temporal trajectories between children with SCP and healthy controls. No significant Group x Time interactions were observed for single-step time, gait cycle duration, or cadence (all P > 0.05). For energy expenditure, a significant Group x Time interaction (P = 0.047) indicated that the SCP group maintained elevated metabolic cost into the third minute while controls exhibited a declining trajectory. Similarly, significant Group x Time interactions were observed for bilateral gastrocnemius (P = 0.002) and tibialis anterior (P = 0.006) normalized root mean square amplitudes, reflecting a greater temporal decline in muscle activation in the SCP group from the second minute onward. CONCLUSION: Children with SCP may exhibit gradual changes in spatial-temporal gait parameters and muscle activation patterns during the later stages of a long walking task. These findings suggest that selected gait and EMG parameters in children with SCP begin to change after approximately 2 min of continuous walking, indicating a potential time window for closer monitoring or structured rest breaks during rehabilitation. Further studies incorporating direct fall-risk assessment and validated fatigue measures are warranted before definitive clinical recommendations can be made. CI - (c) 2026 Zhang, Yu, Guo, Ma, Liu, Kalpen and Li. FAU - Zhang, Lina AU - Zhang L AD - Department of Rehabilitation Medicine, Shandong Medical and Pharmaceutical University Hospital, Binzhou Shandong Province, China. FAU - Yu, Li AU - Yu L AD - Department of Rehabilitation Medicine, Shandong Medical and Pharmaceutical University Hospital, Binzhou Shandong Province, China. FAU - Guo, Haibo AU - Guo H AD - Department of Rehabilitation Medicine, Shandong Medical and Pharmaceutical University Hospital, Binzhou Shandong Province, China. FAU - Ma, Pei AU - Ma P AD - Department of Rehabilitation Medicine, Shandong Medical and Pharmaceutical University Hospital, Binzhou Shandong Province, China. FAU - Liu, Fang AU - Liu F AD - Department of Child Health and Developmental Behavior, Shandong Medical and Pharmaceutical University Hospital, Binzhou Shandong Province, China. FAU - Kalpen, Axel AU - Kalpen A AD - Novel GmbH, Munich, Germany. FAU - Li, Wei AU - Li W AD - Department of Rehabilitation Medicine, Shandong Medical and Pharmaceutical University Hospital, Binzhou Shandong Province, China. LA - eng PT - Journal Article DEP - 20260909 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13597853 OTO - NOTNLM OT - cerebral palsy OT - gait analysis OT - gait variability OT - motor fatigue OT - surface electromyography COIS- AK was employed by Novel GmbH. The remaining author(s) declared that that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/24 12:49 MHDA- 2026/09/24 12:50 PMCR- 2026/09/09 CRDT- 2026/09/24 10:55 PHST- 2026/04/28 00:00 [received] PHST- 2026/08/10 00:00 [revised] PHST- 2026/08/27 00:00 [accepted] PHST- 2026/09/24 12:50 [medline] PHST- 2026/09/24 12:49 [pubmed] PHST- 2026/09/24 10:55 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - 10.3389/fped.2026.1865485 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 9;14:1865485. doi: 10.3389/fped.2026.1865485. eCollection 2026. PMID- 42780256 OWN - NLM STAT- MEDLINE DCOM- 20260924 LR - 20260925 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Interpretable skeleton-based movement profiles for formative feedback in school physical activity education. PG - 1925220 LID - 10.3389/fpubh.2026.1925220 [doi] LID - 1925220 AB - BACKGROUND: Schools are an important setting for developing movement competence and supporting physical activity PA). Teachers provide feedback on how learners move, but individualized observation is difficult to sustain and document in large classes. Existing artificial intelligence (AI) systems typically classify an action or predict one competitive-sport score. These outputs do not identify the specific movement feature that a learner might adjust during practice. METHODS: Using three public human action datasets (NTU RGB+D, Penn Action, and a FineGym subset), we benchmarked five representative skeleton-sequence models-recurrent (LSTM, GRU), graph-based (ST-GCN, CTR-GCN), and a Transformer-under a unified setting, and constructed four interpretable movement-profile indicators from joint coordinates and trajectories: movement amplitude, postural stability, left-right coordination, and temporal consistency. Each indicator was normalized against the same-class reference distribution, providing a relative, interpretable description rather than an expert-certified score. RESULTS: Over five random seeds per dataset, independent-test macro-F1 ranged from 0.76 to 0.97; CTR-GCN obtained the highest mean on every dataset (NTU RGB+D 0.970 +/- 0.003). Paired tests supported its advantage over all four comparators on NTU RGB+D and FineGym, whereas on Penn Action only the comparison with LSTM remained significant after correction. In the feature ablation, the full kinematic input increased macro-F1 from 0.925 to 0.936 on 3D skeletons (Holm-adjusted p = 0.022); the corresponding 2D change from 0.893 to 0.905 was not significant after correction (p = 0.079). Per-action profiles and a same-action case analysis showed that the indicators capture interpretable kinematic structure. The resulting percentiles describe relative tendencies within these datasets; a low percentile does not by itself identify an incorrect movement or constitute an age-appropriate standard for children. CONCLUSION: Skeleton-only movement profiles offer a privacy-reducing, teacher-in-the-loop approach to formative feedback that could support digital PA education and health promotion in schools. As a computational proof-of-concept evaluated on public datasets, the study does not include health or learning outcomes, age-specific K-12 reference distributions, or authentic-classroom validation. Calibration on curriculum-relevant data from children and validation against teacher or movement-expert ratings are required before the profiles can be interpreted as movement-quality feedback or used to support public-health claims. CI - Copyright (c) 2026 Ma, Lei, Li, Yang, Du, Zhu, Zhao and Jia. FAU - Ma, Qixuan AU - Ma Q AD - University of Macau, Taipa, Macau SAR, China. FAU - Lei, Xiao AU - Lei X AD - University of Macau, Taipa, Macau SAR, China. FAU - Li, Feng AU - Li F AD - Institute of Orthopaedics, Nankai University, Tianjin, China. AD - Eugene WuKangYuan (Hangzhou) Health Technology Co., Ltd, Hangzhou, China. FAU - Yang, Chengmao AU - Yang C AD - Institute of Orthopaedics, Nankai University, Tianjin, China. AD - State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China. FAU - Du, Jinsui AU - Du J AD - Xiguan Guangya Experimental School, Liwan District, Guangzhou, China. FAU - Zhu, Jiaxing AU - Zhu J AD - Institute of Orthopaedics, Nankai University, Tianjin, China. AD - Eugene WuKangYuan (Hangzhou) Health Technology Co., Ltd, Hangzhou, China. FAU - Zhao, Dongxin AU - Zhao D AD - Shaanxi University of Technology, Hanzhong, China. FAU - Jia, Zhenghu AU - Jia Z AD - Institute of Orthopaedics, Nankai University, Tianjin, China. AD - Eugene WuKangYuan (Hangzhou) Health Technology Co., Ltd, Hangzhou, China. AD - State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China. LA - eng PT - Journal Article DEP - 20260909 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Schools MH - *Physical Education and Training/methods MH - *Exercise/physiology MH - *Formative Feedback MH - Movement/physiology MH - Artificial Intelligence MH - Child PMC - PMC13597747 OTO - NOTNLM OT - digital health education OT - formative feedback OT - knowledge of performance OT - movement competence OT - physical activity promotion OT - school physical activity education OT - skeleton-based action recognition COIS- FL, JZ, and ZJ were employed by Eugene WuKangYuan (Hangzhou) Health Technology Co., Ltd. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/24 12:49 MHDA- 2026/09/24 12:50 PMCR- 2026/09/09 CRDT- 2026/09/24 10:27 PHST- 2026/07/01 00:00 [received] PHST- 2026/08/07 00:00 [revised] PHST- 2026/08/12 00:00 [accepted] PHST- 2026/09/24 12:50 [medline] PHST- 2026/09/24 12:49 [pubmed] PHST- 2026/09/24 10:27 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1925220 [doi] PST - epublish SO - Front Public Health. 2026 Sep 9;14:1925220. doi: 10.3389/fpubh.2026.1925220. eCollection 2026. PMID- 42777335 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261014 IS - 2352-3964 (Electronic) IS - 2352-3964 (Linking) VI - 132 DP - 2026 Oct TI - Metabolomic profiling of ultra-processed food consumption and cardiovascular risk in Spanish preschool children: a cross-sectional study. PG - 106488 LID - S2352-3964(26)00372-5 [pii] LID - 10.1016/j.ebiom.2026.106488 [doi] LID - 106488 AB - BACKGROUND: Ultra-processed food (UPF) consumption has increased substantially among children worldwide and has been associated with early cardiovascular alterations. We aimed to identify plasma metabolomic profiles associated with UPF consumption in children aged 3-6 years and to assess their association with cardiovascular risk factors. METHODS: This cross-sectional analysis used baseline data from the Childhood Obesity Risk Assessment Longitudinal Study (CORALS), with children recruited between March 2019 and June 2022 through primary schools and health-care centres in seven Spanish cities. 1148 children were included (mean age 5.0 years [SD 1.1]; 50.6% girls) after exclusions due to medical conditions and incomplete or implausible dietary or metabolomic data. Energy-adjusted UPF intake (g/d) was assessed using a validated food frequency questionnaire and categorised with NOVA classification. 249 metabolites were quantified by NMR-based metabolomics, and lipid-related and amino acid-related profiles/scores were derived. A composite cardiovascular risk score (CVRs) was constructed by summing sex-specific, age-adjusted z-scores for fat-mass index, HDL-and LDL-cholesterol, triglycerides, mean arterial pressure, and Homoeostatic Model Assessment for Insulin Resistance. FINDINGS: 19 metabolites were associated with UPF consumption after false discovery rate correction (FDR). A lipid-related score was positively associated with CVRs (beta = 0.511; 95% CI: 0.413-0.610; FDR <0.001) and the amino acid-related score was associated with a lower CVRs (beta = -0.494; 95% CI: -0.667 to -0.321; FDR <0.001). Discrimination of cardiovascular risk beyond covariates alone was higher after inclusion of metabolomic scores, particularly when both scores were considered jointly (DeltaAUC 0.092, 95% CI: 0.013-0.172; p = 0.020). INTERPRETATION: In Spanish pre-schoolers UPF-related metabolomic profiles were associated with different cardiovascular risk factors. These diet-related metabolomic scores capture biological correlates relevant to early cardiovascular health and align with early-life metabolic pattering, supporting future longitudinal studies and prevention strategies. FUNDING: CIBEROBN; Instituto de Salud Carlos III (ISCIII-FIS; EU ERDF/ESF); ISCIII PFIS. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Perez-Acosta, Josue A AU - Perez-Acosta JA AD - Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), Reus, Spain; Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. FAU - Garcia-Gavilan, Jesus F AU - Garcia-Gavilan JF AD - Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), Reus, Spain; Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. FAU - Margara-Escudero, Hernando J AU - Margara-Escudero HJ AD - Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), Reus, Spain; Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. FAU - Aguilera, Concepcion M AU - Aguilera CM AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology (INYTA) and Center of Biomedical Research (CIBM), University of Granada, Granada, 18071, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain. FAU - Leis, Rosaura AU - Leis R AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Unit of Pediatric Gastroenterology, Hepatology and Nutrition, Pediatric Service, Hospital Clinico Universitario de Santiago, 15706, Santiago de Compostela, Spain; Pediatric Nutrition Research Group, Health Research Institute of Santiago de Compostela (IDIS). Unit of Investigation in Nutrition, Growth and Human Development of Galicia-USC, 15706, Santiago de Compostela, Spain. FAU - Gheorghita, Irina AU - Gheorghita I AD - Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Universitat Rovira i Virgili, Pediatric Nutrition and Human Development Research Unit (PediNuR), Reus, Spain. FAU - Miguel-Berges, Maria L AU - Miguel-Berges ML AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Growth, Exercise, Nutrition and Development (GENUD-B34_23R) Research Group, Facultad de Ciencias de la Salud e Instituto Agroalimentario de Aragon (IA2) University of Zaragoza, Zaragoza, Spain. FAU - Navas-Carretero, Santiago AU - Navas-Carretero S AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; University of Navarra, Center for Nutrition Research, 31008, Pamplona, Spain; Universidad de Navarra, Instituto de Nutricion y Salud, 31080, Pamplona, Spain; IdisNA, Navarra Institute for Health Research, Pamplona, Spain. FAU - Sorli, Jose V AU - Sorli JV AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Preventive Medicine and Public Health, University of Valencia, Valencia, Spain. FAU - Lazaro, Iolanda AU - Lazaro I AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Hospital del Mar Research Institute, Barcelona, Spain. FAU - Pastor-Villaescusa, Belen AU - Pastor-Villaescusa B AD - Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS), RD21/0012/0008, Spanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS-SAMID, RD24/0013/0007), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain; Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), University of Cordoba; Cordoba, 14071, Spain. FAU - Vazquez-Cobela, Rocio AU - Vazquez-Cobela R AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Unit of Pediatric Gastroenterology, Hepatology and Nutrition, Pediatric Service, Hospital Clinico Universitario de Santiago, 15706, Santiago de Compostela, Spain; Pediatric Nutrition Research Group, Health Research Institute of Santiago de Compostela (IDIS). Unit of Investigation in Nutrition, Growth and Human Development of Galicia-USC, 15706, Santiago de Compostela, Spain. FAU - Iglesias-Vazquez, Lucia AU - Iglesias-Vazquez L AD - Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), Reus, Spain; Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. FAU - De Miguel-Etayo, Pilar AU - De Miguel-Etayo P AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Growth, Exercise, Nutrition and Development (GENUD-B34_23R) Research Group, Facultad de Ciencias de la Salud e Instituto Agroalimentario de Aragon (IA2) University of Zaragoza, Zaragoza, Spain; Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. FAU - Vazquez-Bolea, Natalia AU - Vazquez-Bolea N AD - University of Navarra, Center for Nutrition Research, 31008, Pamplona, Spain; Universidad de Navarra, Instituto de Nutricion y Salud, 31080, Pamplona, Spain. FAU - Jurado-Castro, Jose Manuel AU - Jurado-Castro JM AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), University of Cordoba; Cordoba, 14071, Spain. FAU - Picans-Leis, Rosaura AU - Picans-Leis R AD - Neonatology Service, RICORS-SAMID-CIBERER, University Clinical Hospital of Santiago de Compostela, Health Research Institute of Santiago de Compostela, Santiago de Compostela, Spain. FAU - Escribano, Joaquin AU - Escribano J AD - Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Universitat Rovira i Virgili, Pediatric Nutrition and Human Development Research Unit (PediNuR), Reus, Spain; Hospital Universitari Sant Joan de Reus, Servicio de Pediatria, Reus, Spain. FAU - Moreno, Luis A AU - Moreno LA AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Growth, Exercise, Nutrition and Development (GENUD-B34_23R) Research Group, Facultad de Ciencias de la Salud e Instituto Agroalimentario de Aragon (IA2) University of Zaragoza, Zaragoza, Spain; Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. FAU - Torre-Aguilar, MJose de la AU - Torre-Aguilar M AD - Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), University of Cordoba; Cordoba, 14071, Spain. FAU - Gil-Campos, Mercedes AU - Gil-Campos M AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), University of Cordoba; Cordoba, 14071, Spain. FAU - Salas-Salvado, Jordi AU - Salas-Salvado J AD - Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), Reus, Spain; Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: jordi.salas@urv.cat. FAU - Babio, Nancy AU - Babio N AD - Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), Reus, Spain; Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: nancy.babio@urv.cat. LA - eng PT - Journal Article DEP - 20260923 PL - Netherlands TA - EBioMedicine JT - EBioMedicine JID - 101647039 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - *Cardiovascular Diseases/epidemiology/etiology/metabolism MH - *Metabolomics/methods MH - Spain/epidemiology MH - Cross-Sectional Studies MH - Child, Preschool MH - Male MH - Child MH - *Metabolome MH - *Fast Foods/adverse effects MH - Biomarkers MH - Heart Disease Risk Factors MH - Risk Factors PMC - PMC13634276 OTO - NOTNLM OT - Cardiometabolic risk OT - Children OT - Metabolomics OT - Ultra-processed foods COIS- Declaration of interests JS-S reports non-financial support in the form of food products (virgin olive oil, almonds, and pistachios) provided by Patrimonio Comunal Olivarero, the Almond Board of California, and American Pistachio Growers, respectively, for pilot study participants. JS-S serves on the scientific advisory boards of the Danone Institute International and the International Nut and Dried Fruit Foundation on an unpaid basis. JS-S has received travel and accommodation support from the International Nut and Dried Fruit Foundation to attend scientific meetings and has participated as a member of the international advisory board of a research project on cashew nut supplementation in type 2 diabetes. Outside the submitted work, JS-S has received honoraria for lectures from the Danone Institute Spain and institutional grants or in-kind support from the International Nut and Dried Fruit Foundation. NVB reports an FPU grant from the Spanish Ministry of Science, Innovation and Universities (MCIU; FPU23/01950). All other authors declare no competing interests. EDAT- 2026/09/23 23:56 MHDA- 2026/10/14 23:31 PMCR- 2026/09/23 CRDT- 2026/09/23 18:02 PHST- 2026/02/23 00:00 [received] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/08 00:00 [accepted] PHST- 2026/10/14 23:31 [medline] PHST- 2026/09/23 23:56 [pubmed] PHST- 2026/09/23 18:02 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - S2352-3964(26)00372-5 [pii] AID - 106488 [pii] AID - 10.1016/j.ebiom.2026.106488 [doi] PST - ppublish SO - EBioMedicine. 2026 Oct;132:106488. doi: 10.1016/j.ebiom.2026.106488. Epub 2026 Sep 23. PMID- 42777198 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260923 IS - 2791-6421 (Electronic) IS - 0041-4301 (Linking) VI - 68 IP - 4 DP - 2026 Sep 11 TI - Esophageal atresia and nutritional outcomes: the influence of anastomotic stricture and gastroesophageal reflux. PG - 662-671 LID - 10.24953/turkjpediatr.2026.6347 [doi] AB - BACKGROUND: Esophageal atresia (EA) is a congenital malformation often associated with long-term gastrointestinal complications and impaired growth. This study aimed to evaluate anthropometric outcomes in children with EA, with particular attention to the impact of associated conditions such as anastomotic stricture and gastroesophageal reflux (GER). METHODS: We conducted a retrospective analysis of patients with type C EA who underwent primary anastomosis between 2005 and 2021. Anthropometric data were collected at four age intervals (<1 year, 1-4 years, 5-11 years, >11 years) and standardized using validated growth charts. Associations between anthropometric parameters and the presence of stricture or GER were analyzed. RESULTS: Fifty-seven patients met the inclusion criteria. Stricture and GER were identified in 32% and 30% of patients, respectively. Infants (<1 year) with stricture had significantly lower BMI Z-scores -2.5 +/- 0.7 than those without stricture (-1.1 +/- 1.1; p=0.0093), while those with GER had significantly lower weight Z-scores (-2.1 +/- 1.0) than those without GER (-1.2 +/- 1.1; p=0.0443). Although most patients showed improvement in anthropometric parameters with age, early growth impairment was consistently observed in association with these complications. CONCLUSIONS: Children with EA are at risk of impaired growth during early childhood, particularly when stricture or GER is present. Regular anthropometric monitoring and early nutritional intervention are crucial, especially within the first year of life. Long-term multidisciplinary follow-up is recommended to optimize developmental outcomes. FAU - Salcedo Arroyo, Paula AU - Salcedo Arroyo P AUID- ORCID: 0000-0003-2579-2094 AD - Department of Pediatrics, Hospital Consorci Sanitari de Terrassa, Terrassa, Spain. AD - Department of Pediatrics, Hospital Universitari Mutua de Terrassa, Terrassa, Spain. FAU - Bragagnini Rodriguez, Paolo AU - Bragagnini Rodriguez P AUID- ORCID: 0000-0002-3053-3436 AD - Pediatric Surgery Department, Pediatric Surgery Research Group GIISA 018, Hospital Universitario Miguel Servet, Zaragoza, Spain. FAU - Fernandez Atuan, Rafael AU - Fernandez Atuan R AUID- ORCID: 0000-0002-3204-0483 AD - Pediatric Surgery Department, Pediatric Surgery Research Group GIISA 018, Hospital Universitario Miguel Servet, Zaragoza, Spain. AD - University of Zaragoza, Zaragoza, Spain. FAU - Garcia Romero, Ruth AU - Garcia Romero R AUID- ORCID: 0000-0002-3017-1340 AD - Department of Pediatric Gastroenterology, Hospital Universitario Miguel Servet, Zaragoza, Spain. FAU - Vargova, Paulina AU - Vargova P AUID- ORCID: 0000-0002-0705-5309 AD - Pediatric Surgery Department, Pediatric Surgery Research Group GIISA 018, Hospital Universitario Miguel Servet, Zaragoza, Spain. FAU - Ros Arnal, Ignacio AU - Ros Arnal I AUID- ORCID: 0000-0003-4163-8003 AD - Department of Pediatric Gastroenterology, Hospital Universitario Miguel Servet, Zaragoza, Spain. FAU - Corona Bellostas, Carolina AU - Corona Bellostas C AUID- ORCID: 0000-0002-7368-1033 AD - Pediatric Surgery Department, Pediatric Surgery Research Group GIISA 018, Hospital Universitario Miguel Servet, Zaragoza, Spain. AD - University of Zaragoza, Zaragoza, Spain. LA - eng PT - Journal Article DEP - 20260911 PL - Turkey TA - Turk J Pediatr JT - The Turkish journal of pediatrics JID - 0417505 SB - IM MH - Humans MH - *Esophageal Atresia/surgery/complications MH - *Gastroesophageal Reflux/complications/etiology MH - Retrospective Studies MH - Female MH - Male MH - Infant MH - Child MH - Child, Preschool MH - *Esophageal Stenosis/etiology MH - Anastomosis, Surgical/adverse effects MH - *Postoperative Complications MH - *Nutritional Status OTO - NOTNLM OT - esophageal atresia OT - esophageal stricture OT - gastroesophageal reflux OT - growth OT - nutritional status EDAT- 2026/09/23 17:37 MHDA- 2026/09/23 23:56 CRDT- 2026/09/23 16:06 PHST- 2025/05/23 00:00 [received] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/09/23 23:56 [medline] PHST- 2026/09/23 17:37 [pubmed] PHST- 2026/09/23 16:06 [entrez] AID - 6347 [pii] AID - 10.24953/turkjpediatr.2026.6347 [doi] PST - epublish SO - Turk J Pediatr. 2026 Sep 11;68(4):662-671. doi: 10.24953/turkjpediatr.2026.6347. PMID- 42776278 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20261001 IS - 1432-1335 (Electronic) IS - 0171-5216 (Print) IS - 0171-5216 (Linking) VI - 152 IP - 9 DP - 2026 Sep 22 TI - Sleep quality and disturbances in adolescents and young adults with cancer compared to a healthy comparison group: results of the AYA-LE study. LID - 10.1007/s00432-026-06627-1 [doi] LID - 185 AB - PURPOSE: Adolescents and young adults (AYAs) with cancer often exhibit riskier health behaviors, including poorer sleep patterns, compared to older individuals. Research on the relationship between cancer and sleep quality in AYA patients has yielded inconsistent results. This study investigates sleep quality in AYA patients compared to a healthy comparison group and examines associated sociodemographic, clinical, and psychosocial variables as well as physical activity. METHODS: The prospective observational study included 407 AYA patients aged 18-39 years at diagnosis and 372 healthy participants aged 18-45 years, with data collected from May-September 2019. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Validated questionnaires measured self-efficacy, social support, anxiety, depression, quality of life, lack of energy, and physical activity. Multiple regression analyses were employed to explore the variables associated with sleep quality. RESULTS: The mean age of the AYA patients was 34.8 years (75.2% women) and 32.3 years of the healthy participants (61.8% women). AYA patients demonstrated significantly poorer subjective sleep quality (d=0.31), lower sleep efficiency (d=0.15), more frequent sleep disturbances (d=0.23), greater use of sleep medication (d=0.25), and higher daytime dysfunction (d=0.29). Anxiety, depression (HADS), quality of life (EORTC), and unmet needs for support through lack of energy (SCNS) were significantly associated with PSQI (adjusted R(2)=0.35). CONCLUSION: These findings underscore the relevance of sleep disturbances in AYA patients and support greater attention to sleep disturbances in survivorship care. Routine assessment of sleep quality may help identify AYA patients who could benefit from further evaluation and appropriate support. CI - (c) 2026. The Author(s). FAU - Wieland, Carolin AU - Wieland C AUID- ORCID: 0009-0007-2507-5294 AD - Department of Medical Psychology and Medical Sociology, Comprehensive Cancer Center Central Germany (CCCG), University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany. FAU - Friedrich, Michael AU - Friedrich M AUID- ORCID: 0000-0002-0528-1564 AD - Department of Medical Psychology and Medical Sociology, Comprehensive Cancer Center Central Germany (CCCG), University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany. FAU - Sender, Annekathrin AU - Sender A AUID- ORCID: 0000-0002-5457-4021 AD - Department of Medical Psychology and Medical Sociology, Comprehensive Cancer Center Central Germany (CCCG), University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany. FAU - Leuteritz, Katja AU - Leuteritz K AUID- ORCID: 0000-0002-5942-0988 AD - Department of Medical Psychology and Medical Sociology, Comprehensive Cancer Center Central Germany (CCCG), University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany. FAU - Brock, Hannah AU - Brock H AUID- ORCID: 0000-0002-9905-9488 AD - Department of Medical Psychology and Medical Sociology, Comprehensive Cancer Center Central Germany (CCCG), University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany. FAU - Geue, Kristina AU - Geue K AUID- ORCID: 0000-0001-6590-5650 AD - University Clinic for Psychosomatic Medicine and Psychotherapy, University Medical Center Magdeburg, Otto-von-Guericke Universitat Magdeburg, Magdeburg, Germany. FAU - Mehnert-Theuerkauf, Anja AU - Mehnert-Theuerkauf A AUID- ORCID: 0000-0002-6872-9805 AD - Department of Medical Psychology and Medical Sociology, Comprehensive Cancer Center Central Germany (CCCG), University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany. FAU - Richter, Diana AU - Richter D AUID- ORCID: 0000-0003-3977-2801 AD - Department of Medical Psychology and Medical Sociology, Comprehensive Cancer Center Central Germany (CCCG), University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany. diana.richter@medizin.uni-leipzig.de. LA - eng PT - Comparative Study PT - Journal Article PT - Observational Study DEP - 20260922 PL - Germany TA - J Cancer Res Clin Oncol JT - Journal of cancer research and clinical oncology JID - 7902060 SB - IM MH - Humans MH - Female MH - Adult MH - Young Adult MH - Adolescent MH - *Neoplasms/complications/psychology/physiopathology MH - *Sleep Quality MH - Male MH - *Sleep Wake Disorders/etiology/epidemiology MH - Prospective Studies MH - Quality of Life MH - Surveys and Questionnaires MH - Middle Aged MH - Case-Control Studies MH - Depression PMC - PMC13601403 OTO - NOTNLM OT - AYA OT - Cancer OT - PSQI OT - Psycho-oncology OT - Sleep OT - Survivorship COIS- Declarations. Conflict of interest: The authors declare no conflict of interest. EDAT- 2026/09/23 17:36 MHDA- 2026/09/23 17:37 PMCR- 2026/09/22 CRDT- 2026/09/23 11:14 PHST- 2026/08/11 00:00 [received] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/09/23 17:37 [medline] PHST- 2026/09/23 17:36 [pubmed] PHST- 2026/09/23 11:14 [entrez] PHST- 2026/09/22 00:00 [pmc-release] AID - 10.1007/s00432-026-06627-1 [pii] AID - 6627 [pii] AID - 10.1007/s00432-026-06627-1 [doi] PST - epublish SO - J Cancer Res Clin Oncol. 2026 Sep 22;152(9):185. doi: 10.1007/s00432-026-06627-1. PMID- 42776174 OWN - NLM STAT- Publisher LR - 20260923 IS - 1558-9110 (Electronic) IS - 1058-0360 (Linking) DP - 2026 Sep 23 TI - The Management of Swallowing Disorders in Children With Spinal Muscular Atrophy Type 1: A Scoping Review. PG - 1-22 LID - 10.1044/2026_AJSLP-25-00460 [doi] AB - PURPOSE: Spinal muscular atrophy Type 1 (SMA1) is a rare autosomal recessive neuromuscular disorder with progressive muscle weakness and atrophy. Dysphagia is common among children with SMA1, and its complications are frequently documented. This scoping review aimed to describe the management of swallowing disorders in this population. METHOD: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, four electronic databases were searched (PubMed, Embase, CINAHL, and Cochrane Library) for studies on children with SMA1. We investigated the management of swallowing disorders in children with SMA1, including methods and protocols used to assess swallowing and feeding, and treatment option. The quality of included studies was assessed using the Joanna Briggs Institute checklists; two independent researchers conducted study selection and data extraction. RESULTS: Thirty-eight studies with a total of 1,784 SMA1 patients were included. Swallowing was evaluated using instrumental methods (flexible endoscopic evaluation of swallowing and videofluoroscopic swallowing study) and clinical assessments, with one validated protocol identified for pediatric SMA (Oral and Swallowing Abilities Tool). Delayed initiation of swallowing, oral impairment, pharyngeal residues, and aspiration were frequently reported. Percutaneous endoscopic gastrostomy was used in cases of severe dysphagia, malnutrition, and failure to thrive. Few studies reported information on compensatory strategies and rehabilitative treatments. CONCLUSION: Further research is needed to standardize swallowing assessment approaches and to evaluate the effectiveness of rehabilitative and compensatory interventions in children with SMA1. SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.33746656. FAU - Rocca, Sara AU - Rocca S AUID- ORCID: 0000-0002-4144-7269 AD - Department of Biomedical and Clinical Sciences, Universita degli Studi di Milano, Italy. FAU - Pizzi, Laura AU - Pizzi L AD - Department of Biomedical and Clinical Sciences, Universita degli Studi di Milano, Italy. FAU - Pizzorni, Nicole AU - Pizzorni N AD - Department of Biomedical and Clinical Sciences, Universita degli Studi di Milano, Italy. FAU - Gandolfi, Sofia AU - Gandolfi S AD - Developmental Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy. FAU - Masson, Riccardo AU - Masson R AD - Developmental Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy. FAU - Schindler, Antonio AU - Schindler A AD - Department of Biomedical and Clinical Sciences, Universita degli Studi di Milano, Italy. AD - Phoniatric and Speech and Language Pathology Unit, V. Buzzi Children Hospital, ASST Fatebenefratelli Sacco, Milan, Italy. LA - eng PT - Journal Article DEP - 20260923 PL - United States TA - Am J Speech Lang Pathol JT - American journal of speech-language pathology JID - 9114726 SB - IM EDAT- 2026/09/23 17:36 MHDA- 2026/09/23 17:36 CRDT- 2026/09/23 11:07 PHST- 2026/09/23 17:36 [medline] PHST- 2026/09/23 17:36 [pubmed] PHST- 2026/09/23 11:07 [entrez] AID - 10.1044/2026_AJSLP-25-00460 [doi] PST - aheadofprint SO - Am J Speech Lang Pathol. 2026 Sep 23:1-22. doi: 10.1044/2026_AJSLP-25-00460. PMID- 42774383 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260924 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Nutritional determinants, childhood morbidity patterns, and healthcare utilization among Chinese children: a population-based study. PG - 1909080 LID - 10.3389/fpubh.2026.1909080 [doi] LID - 1909080 AB - BACKGROUND: Childhood nutrition has a substantial impact on growth, disease susceptibility, and use of health care services. Malnutrition is a double burden in China, characterized by chronic undernutrition and childhood obesity. OBJECTIVE: The objective of this study was to explore the relationships between nutrition determinants, childhood morbidity patterns and health care utilization in the Chinese population. METHODOLOGY: This retrospective, institution-based study analyzed routinely collected health records from 720 children aged 3-14 years who received care at a tertiary healthcare center in Nanchong, Sichuan, China, between 2021 and 2025. Nutritional status and dietary quality were determined by using the routine health records. Morbidity burden and service use were assessed using medical records for children. Independent predictors were identified by using multivariable logistic regression. RESULTS: 15.1% of participants were undernourished, and 20.3% were overweight or obese. The childhood morbidity burden was observed in 25.7% of children and was significantly higher in children who were undernourished and obese (p < 0.001). Known-groups validity testing showed that all 9 individual components of the dietary-quality score varied significantly and monotonically across derived tiers (Cochran-Armitage p < 0.001 for all), supporting the internal coherence of the measure. Poor dietary quality, as measured by this study-specific composite index, was an independent risk factor for a high burden of morbidity (Adjusted odds ratio (AOR) = 2.76, 95% CI: 1.89-4.05). High healthcare utilization was observed in 25.8% of participants. It was independently associated with high morbidity burden (AOR = 3.87, 95% CI: 2.71-5.54), undernutrition (AOR = 2.09, 95% CI: 1.37-3.20), obesity (AOR = 2.34, 95% CI: 1.40-3.89), poor dietary quality (AOR = 1.96, 95% CI: 1.32-2.92), low household income (AOR = 1.58, 95% CI: 1.07-2.34), and grandparent caregiving (AOR = 1.45, 95% CI: 1.01-2.11). CONCLUSION: Undernutrition and overweight/obesity, in addition to poor diet quality, are associated with higher morbidity rates and utilization of health services in children in China. The findings suggest that nutritional status and dietary quality are significantly associated with childhood morbidity burden and healthcare utilization. CI - Copyright (c) 2026 Wang, Liao, Zhang, Zhao, Zhang and Huang. FAU - Wang, Pengli AU - Wang P AD - Department of Pediatric Surgery, Beijing Anzhen Nanchong Hospital, Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical School of North Sichuan Medical University, Nanchong, Sichuan, China. FAU - Liao, Wenhua AU - Liao W AD - Department of Pediatric Surgery, Beijing Anzhen Nanchong Hospital, Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical School of North Sichuan Medical University, Nanchong, Sichuan, China. FAU - Zhang, Li AU - Zhang L AD - Department of Pediatric Surgery, Beijing Anzhen Nanchong Hospital, Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical School of North Sichuan Medical University, Nanchong, Sichuan, China. FAU - Zhao, Mingjia AU - Zhao M AD - Department of Pediatric Surgery, Beijing Anzhen Nanchong Hospital, Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical School of North Sichuan Medical University, Nanchong, Sichuan, China. FAU - Zhang, Dong AU - Zhang D AD - Department of Pediatric Surgery, Beijing Anzhen Nanchong Hospital, Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical School of North Sichuan Medical University, Nanchong, Sichuan, China. FAU - Huang, Nanxiang AU - Huang N AD - Department of Pediatric Surgery, Beijing Anzhen Nanchong Hospital, Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical School of North Sichuan Medical University, Nanchong, Sichuan, China. LA - eng PT - Journal Article DEP - 20260908 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - Chinese people SB - IM MH - Humans MH - Female MH - China/epidemiology MH - Child, Preschool MH - Child MH - Retrospective Studies MH - Male MH - *Patient Acceptance of Health Care/statistics & numerical data MH - Adolescent MH - *Nutritional Status MH - Morbidity MH - Malnutrition/epidemiology MH - *Pediatric Obesity/epidemiology MH - East Asian People PMC - PMC13593838 OTO - NOTNLM OT - Chinese children OT - childhood nutrition OT - dietary quality OT - healthcare utilization OT - malnutrition OT - morbidity burden COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/23 11:50 MHDA- 2026/09/23 11:51 PMCR- 2026/09/08 CRDT- 2026/09/23 06:13 PHST- 2026/06/14 00:00 [received] PHST- 2026/08/06 00:00 [revised] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/23 11:51 [medline] PHST- 2026/09/23 11:50 [pubmed] PHST- 2026/09/23 06:13 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1909080 [doi] PST - epublish SO - Front Public Health. 2026 Sep 8;14:1909080. doi: 10.3389/fpubh.2026.1909080. eCollection 2026. PMID- 42773043 OWN - NLM STAT- Publisher LR - 20260922 IS - 1578-1879 (Electronic) IS - 0214-9168 (Linking) DP - 2026 Sep 22 TI - Early-life atherogenesis: Mechanistic pathways, risk architecture, and clinical implications in pediatric populations. PG - 500964 LID - S0214-9168(26)00073-2 [pii] LID - 10.1016/j.arteri.2026.500964 [doi] AB - Atherosclerosis is now recognized as a long-term biological process whose origins may be established early in life, well before the clinical expression of cardiovascular disease. The increasing prevalence of pediatric obesity, insulin resistance, sedentary behavior, and unhealthy dietary patterns has intensified interest in understanding how vascular risk is shaped from childhood onward. This narrative review examines early-life atherogenesis in pediatric populations from mechanistic, clinical, and preventive perspectives, with emphasis on cardiometabolic risk factors, endothelial dysfunction, vascular inflammation, and potential biomarkers of subclinical vascular injury. A narrative synthesis of current evidence was conducted to integrate mechanistic, clinical, and preventive aspects of pediatric atherogenesis, focusing on biological pathways, developmental determinants, lifestyle-related exposures, and emerging tools for early risk stratification. Sustained exposure to adverse cardiometabolic factors during childhood and adolescence may promote subclinical vascular alterations and establish risk trajectories that persist into adulthood. This process involves the interaction of atherogenic dyslipidemia, oxidative stress, chronic low-grade inflammation, immune activation, endothelial dysfunction, and vascular remodeling. Circulating biomarkers of endothelial activation and vascular inflammation may serve as early indicators of subclinical injury and provide complementary information for identifying children with increased cardiometabolic vulnerability. Genetic susceptibility, pubertal development, sex-related differences, socioeconomic conditions, and lifestyle-related factors further modulate the expression and severity of risk. Early identification of children with unfavorable cardiometabolic profiles requires the integration of conventional clinical assessment with biomarkers, derived lipid parameters, and complementary stratification tools that still require further pediatric validation. Understanding pediatric atherogenesis as an integrated process shaped by biology, development, and environment may help guide more timely strategies for prevention, follow-up, and intervention aimed at reducing future cardiovascular burden. CI - Copyright (c) 2026 Sociedad Espanola de Arteriosclerosis. Publicado por Elsevier Espana, S.L.U. All rights reserved. FAU - de la Torre-Sosa, Citlaly Natali AU - de la Torre-Sosa CN AD - Departamento de Salud, El Colegio de la Frontera Sur (ECOSUR), Unidad Villahermosa, Carretera a Reforma Km. 15.5 s/n, Rancheria Guineo 2da Seccion, CP 86280, Villahermosa, Tabasco, Mexico. FAU - Lopez-Marure, Rebeca AU - Lopez-Marure R AD - Departamento de Fisiologia (Biologia Celular), Instituto Nacional de Cardiologia "Ignacio Chavez", Tlalpan, CP 14080, Ciudad de Mexico, Mexico. FAU - Ochoa-Diaz-Lopez, Hector AU - Ochoa-Diaz-Lopez H AD - Departamento de Salud, El Colegio de la Frontera Sur (ECOSUR), Unidad San Cristobal, San Cristobal de las Casas, Chiapas, Mexico. FAU - Irecta-Najera, Cesar Antonio AU - Irecta-Najera CA AD - Departamento de Salud, El Colegio de la Frontera Sur (ECOSUR), Unidad Villahermosa, Carretera a Reforma Km. 15.5 s/n, Rancheria Guineo 2da Seccion, CP 86280, Villahermosa, Tabasco, Mexico. Electronic address: cirecta@ecosur.mx. LA - eng LA - spa PT - Journal Article PT - Review DEP - 20260922 PL - Spain TA - Clin Investig Arterioscler JT - Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis JID - 9208512 SB - IM OTO - NOTNLM OT - Aterogenesis OT - Atherogenesis OT - Cardiovascular risk factors OT - Epidemiology OT - Epidemiologia OT - Factores de riesgo cardiovascular OT - Pediatric population OT - Poblacion pediatrica EDAT- 2026/09/22 23:33 MHDA- 2026/09/22 23:33 CRDT- 2026/09/22 21:57 PHST- 2026/06/11 00:00 [received] PHST- 2026/08/05 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/09/22 23:33 [medline] PHST- 2026/09/22 23:33 [pubmed] PHST- 2026/09/22 21:57 [entrez] AID - S0214-9168(26)00073-2 [pii] AID - 10.1016/j.arteri.2026.500964 [doi] PST - aheadofprint SO - Clin Investig Arterioscler. 2026 Sep 22:500964. doi: 10.1016/j.arteri.2026.500964. PMID- 42772898 OWN - NLM STAT- Publisher LR - 20260922 IS - 1468-3296 (Electronic) IS - 0040-6376 (Linking) DP - 2026 Sep 22 TI - Systematic misclassification of lung function in Indian adolescents using GLI-2012 reference equations: evidence from the multicity APEAL cohort. LID - thorax-2026-225309 [pii] LID - 10.1136/thorax-2026-225309 [doi] AB - BACKGROUND: Accurate spirometric interpretation depends on appropriate reference equations. The Global Lung Function Initiative (GLI-2012) equations are widely used internationally, but South Asian populations were sparsely represented in their derivation and their applicability in Indian adolescents remains uncertain. METHODS: We performed a cross-sectional analysis of baseline data from the multicity Air Pollution Exposure on Adolescents' Lungs cohort. Healthy, non-smoking school-going adolescents aged 11-14 years from Delhi, Mumbai, Bengaluru and Mysuru underwent spirometry using standardised American Thoracic Society/European Respiratory Society procedures. GLI-2012 z-scores for forced expiratory volume in 1 s (FEV(1)), forced vital capacity (FVC) and FEV(1)/FVC were calculated using the Asian reference category. Fit was assessed using mean z-scores and the proportion below the lower limit of normal (LLN; z<-1.645). RESULTS: Among 4175 adolescents (2148 males), mean z-scores were -2.44 (SD 1.27) for FEV(1), -1.34 (0.93) for FVC and -0.78 (1.11) for FEV(1)/FVC, all well outside the accepted +/-0.5 range for adequate fit. Overall, 74.6% were below the LLN for FEV(1), 36.8% for FVC and 19.3% for FEV(1)/FVC, compared with the expected 5% in a well-calibrated healthy population. The leftward shift in z-score distributions was consistent across sex, city, age, height and body mass index strata. CONCLUSION: GLI-2012 equations, as currently applied in the absence of South Asian-specific references, demonstrated substantial calibration mismatch relative to this cohort of Indian adolescents and risk major overclassification of low lung function. Population-specific validation and recalibration are needed before routine clinical or epidemiological use in this population. CI - (c) Author(s) (or their employer(s)) 2026. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Samdarshi, Priya AU - Samdarshi P AUID- ORCID: 0009-0007-6396-0876 AD - Environmental Science and Engineering Department, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India. FAU - Mahesh, Padukudru Anand AU - Mahesh PA AUID- ORCID: 0000-0003-1632-5945 AD - Respiratory Medicine, JSS Medical College and Hospital, Mysore, Karnataka, India. FAU - Patil, Swapnali AU - Patil S AD - Environmental Science and Engineering Department, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India. FAU - Mohan, Anant AU - Mohan A AD - Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences New Delhi, New Delhi, Delhi, India. FAU - D'Souza, George AU - D'Souza G AD - Department of Pulmonary Medicine, St John's Medical College, Bengaluru, Karnataka, India. FAU - Thimmulappa, Rajesh AU - Thimmulappa R AD - Department of Biochemistry, JSS Medical College, Mysuru, Karnataka, India. FAU - Agrawal, Twinkle AU - Agrawal T AD - Department of Community Health, St John's National Academy of Health Sciences, Bengaluru, Karnataka, India. FAU - Biligere Siddaiah, Jayaraj AU - Biligere Siddaiah J AD - Department of Respiratory Medicine, JSS Medical College, Mysuru, Karnataka, India. FAU - Phuleria, Harish Chandra AU - Phuleria HC AD - Environmental Science and Engineering Department, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India phuleria@iitb.ac.in. AD - Centre for Climate Studies, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India. LA - eng PT - Journal Article DEP - 20260922 PL - England TA - Thorax JT - Thorax JID - 0417353 SB - IM OTO - NOTNLM OT - Forced Expiratory Volume OT - Respiratory Function Tests OT - Respiratory Infection OT - Respiratory Measurement COIS- Competing interests: None declared. EDAT- 2026/09/22 23:33 MHDA- 2026/09/22 23:33 CRDT- 2026/09/22 21:23 PHST- 2026/04/25 00:00 [received] PHST- 2026/09/03 00:00 [accepted] PHST- 2026/09/22 23:33 [medline] PHST- 2026/09/22 23:33 [pubmed] PHST- 2026/09/22 21:23 [entrez] AID - thorax-2026-225309 [pii] AID - 10.1136/thorax-2026-225309 [doi] PST - aheadofprint SO - Thorax. 2026 Sep 22:thorax-2026-225309. doi: 10.1136/thorax-2026-225309. PMID- 42772725 OWN - NLM STAT- Publisher LR - 20260922 IS - 1543-2920 (Electronic) IS - 0899-8493 (Linking) DP - 2026 Sep 22 TI - Test-Retest Reliability of In Vivo Structure and Mechanical Properties of the Achilles Tendon in Youth With Obesity. PG - 1-9 LID - 10.1123/pes.2025-0127 [doi] AB - PURPOSE: To assess the test-retest reliability of in vivo Achilles tendon (AT) structure and mechanical properties in youth with obesity. METHODS: Participants (11 males; 12 females; age: 12.00 [2.07] y; body mass index z score: 2.93 [0.59]) were assessed for AT (1) length, (2) cross-sectional area, (3) moment arm, (4) force, (5) deformation, (6) stress, (7) strain, (8) stiffness, (9) Young's modulus, (10) plantar flexor maximal isometric voluntary contraction, and (11) tibialis anterior co-activation. Reliability was assessed using the intraclass correlation coefficient, coefficient of variation, Bland-Altman, standard error of the measurement, and minimum detectable change. The intraclass correlation coefficient values were classified as excellent (>/=.90), good (>/=.75 to <.90), moderate (>.49 to <.75), and poor ( control beliefs [95% CI (0.1135, 0.2500)]. Perceived susceptibility and barriers were indirectly related to lower control beliefs, and this relationship did not operate through attitude. Subjective norm was associated with intention, fully mediated by control beliefs (Effect = 0.3505). Control beliefs showed the largest predictive effect size on intention in the present model (beta = 0.824, p < 0.001). CONCLUSION: Continuous post-injury exercise intention was associated with a stepwise path of attitude --> control beliefs --> intention. Perceived health benefits were associated with intention through this chain, while the pattern for perceived severity was consistent with fear-avoidance theory. Control beliefs connected internal values and social norms. The findings suggest that interventions may benefit from shifting from risk intimidation to benefit empowerment, and from reconstructing rehabilitation control through social support networks-though these candidate directions await experimental validation. CI - Copyright (c) 2026 Hu and Chen. FAU - Hu, Xuanming AU - Hu X AD - School of Sports Science and Physical Education, Nanjing Normal University, Nanjing, Jiangsu, China. FAU - Chen, Peiyou AU - Chen P AD - School of Sports Science and Physical Education, Nanjing Normal University, Nanjing, Jiangsu, China. LA - eng PT - Journal Article DEP - 20260907 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Intention MH - Theory of Planned Behavior MH - *Athletic Injuries/rehabilitation/psychology MH - Female MH - Cross-Sectional Studies MH - Male MH - Young Adult MH - Universities MH - *Exercise/psychology MH - *Health Belief Model MH - Self Efficacy MH - *Students/psychology/statistics & numerical data MH - Surveys and Questionnaires MH - Adult MH - Adolescent PMC - PMC13590716 OTO - NOTNLM OT - Health Belief Model OT - Theory of Planned Behavior OT - chained mediation model OT - control beliefs regarding exercise rehabilitation OT - university students COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/22 12:42 MHDA- 2026/09/22 12:43 PMCR- 2026/09/07 CRDT- 2026/09/22 05:43 PHST- 2026/05/29 00:00 [received] PHST- 2026/08/12 00:00 [revised] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/22 12:43 [medline] PHST- 2026/09/22 12:42 [pubmed] PHST- 2026/09/22 05:43 [entrez] PHST- 2026/09/07 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1894556 [doi] PST - epublish SO - Front Public Health. 2026 Sep 7;14:1894556. doi: 10.3389/fpubh.2026.1894556. eCollection 2026. PMID- 42768389 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260922 LR - 20260923 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 14 IP - 1 DP - 2026 Aug 11 TI - Validation of the Turkish parent-reported Diabetes Eating Problem Survey-Revised (DEPS-R) for screening disordered eating behaviors in adolescents with Type 1 diabetes. LID - 10.1186/s40337-026-01735-2 [doi] LID - 222 AB - BACKGROUND: Adolescents with Type 1 diabetes are at increased risk of eating disorders, which have been associated with suboptimal metabolic control and an increased risk of complications. Reliable and culturally adapted screening tools are essential for early identification. However, the parent-reported version of the Diabetes Eating Problem Survey-Revised (DEPS-R) has not yet been validated in Turkish; therefore, this study aimed to evaluate its validity and reliability in adolescents aged 10-17 years years with type 1 diabetes. METHODS: This methodological validation study included 96 adolescents (45 boys, 51 girls) aged 10-17 years with Type 1 diabetes and their parents. Linguistic and cultural adaptation procedures were conducted in accordance with standard cross-cultural validation guidelines. Parents completed the parent-reported DEPS-R and the Problem Areas in Diabetes-Parents of Teens (P-PAID-T). Adolescents completed the self-reported DEPS-R. Construct validity was assessed using correlation analyses. Exploratory and confirmatory factor analyses were performed to evaluate structural validity. Internal consistency was assessed using Cronbach's alpha, and test-retest reliability was examined using intraclass correlation coefficients (ICC). RESULTS: The parent-reported DEPS-R demonstrated good internal consistency (Cronbach's alpha = 0.852; McDonald's omega = 0.851) and good test-retest reliability (ICC = 0.83), with a strong correlation between the two administrations (r = 0.89). Exploratory and confirmatory factor analyses supported a single-factor structure and demonstrated with acceptable model fit (chi(2)/df = 1.629; RMSEA = 0.080; CFI = 0.874; TLI = 0.848). Parent-reported DEPS-R scores were correlated with self-reported DEPS-R scores (r = 0.506, p < 0.001) and P-PAID-T scores (r = 0.458, p < 0.001), supporting construct validity. A positive correlation was also observed between duration of diabetes and DEPS-R scores (r = 0.223, p = 0.029). No significant associations were observed between DEPS-R scores and metabolic indicators, including HbA1c, ketoacidosis episodes, or diabetes-related hospital visits. CONCLUSION: The Turkish parent-reported DEPS-R is a valid and reliable instrument for screening disordered eating behaviors in adolescents with Type 1 diabetes. Its use in both clinical and research settings may facilitate early detection and improve understanding of the relationship between eating behaviors and metabolic outcomes in this high-risk population. CI - (c) 2026. The Author(s). FAU - Arslan, Neslihan AU - Arslan N AUID- ORCID: 0000-0002-1232-8009 AD - Department of Nutrition and Dietetics, Gulhane Faculty of Health Sciences, Saglik Bilimleri University, Ankara, Turkiye. akdeniz.neslihan91@gmail.com. FAU - Ayyildiz, Feride AU - Ayyildiz F AUID- ORCID: 0000-0003-2828-3850 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara, Turkiye. FAU - Yassibas, Emine AU - Yassibas E AUID- ORCID: 0000-0002-8784-3371 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara, Turkiye. FAU - Esin, Kubra AU - Esin K AUID- ORCID: 0000-0002-2687-1811 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Tokat Gaziosmanpasa University, Tokat, Turkiye. FAU - Bayramoglu, Elvan AU - Bayramoglu E AUID- ORCID: 0000-0002-6732-8823 AD - Department of Pediatric Endocrinology, Cerrahpasa Faculty of Medicine, Istanbul University Cerrahpasa, Istanbul, Turkiye. FAU - Turan, Hande AU - Turan H AUID- ORCID: 0000-0003-0121-3756 AD - Department of Pediatric Endocrinology, Cerrahpasa Faculty of Medicine, Istanbul University Cerrahpasa, Istanbul, Turkiye. FAU - Evliyaoglu, Olcay AU - Evliyaoglu O AUID- ORCID: 0000-0003-4851-8637 AD - Department of Pediatric Endocrinology, Cerrahpasa Faculty of Medicine, Istanbul University Cerrahpasa, Istanbul, Turkiye. FAU - Gunes Kaya, Didem AU - Gunes Kaya D AUID- ORCID: 0000-0003-0791-916X AD - Department of Pediatrics, Cerrahpasa Faculty of Medicine, Istanbul University Cerrahpasa, Istanbul, Turkiye. LA - eng PT - Journal Article DEP - 20260811 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC13591920 OAB - Disordered eating has been reported to be more common among adolescents with type 1 diabetes than among their healthy peers. In this group, disordered eating may lead to poorer metabolic control and make diabetes management more difficult. However, questionnaires completed by adolescents may not always fully reflect actual behaviors, as young people may underreport certain behaviors or may not always be fully aware of them. For this reason, parent-reported assessments such as the parent reported Diabetes Eating Problem Survey-Revised (DEPS-R) may provide an additional and useful perspective for identifying eating-related problems in adolescents with type 1 diabetes. In this study, we evaluated a parent-reported version of the DEPS-R in Turkish families of adolescents with type 1 diabetes. Our findings suggest that this parent-reported version is a reliable tool for identifying possible eating-related problems. Using parent-reported assessments of disordered eating may help healthcare professionals recognize problems earlier and provide timely support for adolescents with type 1 diabetes and their families. OABL- eng OTO - NOTNLM OT - Adolescents OT - Diabetes Eating Problem Survey-Revised (DEPS-R) OT - Disordered eating OT - Parent report OT - Type 1 diabetes OT - Validation COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the principles of the Declaration of Helsinki. Ethical approval for the study was obtained from the Tokat Gaziosmanpasa University Health and Sports Sciences Research Ethics Committee (Decision No: 01.09); date: 07.11.2025). Written informed consent was obtained from the parents of all participants, and adolescents provided assent before participating in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/22 05:37 MHDA- 2026/09/22 05:38 PMCR- 2026/08/11 CRDT- 2026/09/22 00:40 PHST- 2026/03/16 00:00 [received] PHST- 2026/08/02 00:00 [accepted] PHST- 2026/09/22 05:38 [medline] PHST- 2026/09/22 05:37 [pubmed] PHST- 2026/09/22 00:40 [entrez] PHST- 2026/08/11 00:00 [pmc-release] AID - 10.1186/s40337-026-01735-2 [pii] AID - 1735 [pii] AID - 10.1186/s40337-026-01735-2 [doi] PST - epublish SO - J Eat Disord. 2026 Aug 11;14(1):222. doi: 10.1186/s40337-026-01735-2. PMID- 42766722 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260921 LR - 20260923 IS - 2561-6722 (Electronic) IS - 2561-6722 (Linking) VI - 9 DP - 2026 Sep 21 TI - Generative AI Engagement and Perceived Nutrition-Oriented Feeding Practices Among Urban Indonesian Mothers: Mixed Methods Study. PG - e100061 LID - 10.2196/100061 [doi] LID - e100061 AB - BACKGROUND: The Asia-Pacific region faces an escalating double burden of malnutrition, with childhood obesity now affecting more than 113 million children aged 0-19 years. A demographic of highly educated, digitally literate urban mothers-referred to in this study using the descriptive label "Alpha Mother"-increasingly draws on generative AI as a source of toddler nutrition information. Yet, whether this shift empowers or undermines quality feeding practices remains empirically untested. OBJECTIVE: This study examined how generative artificial intelligence (AI) engagement is associated with perceived nutrition-oriented feeding practices among urban Alpha Mothers in Indonesia, with cognitive empowerment and parental self-compassion as intervening variables, and eHealth self-efficacy as a moderator. The study contextually refined 5 AI engagement dimensions, organized through an AI parenting nutrition alignment approach. METHODS: An exploratory sequential mixed methods design was used. Phase 1 comprised semistructured interviews with 10 Alpha Mothers and used hybrid deductive-inductive thematic analysis to contextually refine 5 literature-informed AI engagement constructs: AI algorithmic trust, AI health information quality, AI personalization fit perception, AI information-seeking intensity, and AI social proof sensitivity. These informed a survey instrument developed through the qualitative phase and refined against previously validated scales in phase 2, recruiting 442 respondents across 4 Indonesian urban centers. A 14-hypothesis structural model was tested using PLS-SEM (partial least squares-structural equation modeling). RESULTS: Twelve of 14 hypotheses were supported. The model demonstrated substantial explanatory power for cognitive empowerment (R(2)=0.661) and parental self-compassion (R(2)=0.719), while perceived nutrition-oriented feeding practices yielded a more modest value (R(2)=0.280). This result reflects the multifactorial nature of self-reported nutrition-oriented feeding practices, which is shaped by numerous personal, cultural, and situational factors beyond AI engagement. AI algorithmic trust showed the strongest association with parental self-compassion (beta=.479; P<.001), while AI personalization fit perception most strongly predicted cognitive empowerment (beta=.275; P<.001). Both intervening variables were significantly associated with nutrition-oriented feeding practices, with cognitive empowerment (beta=.232; P=.003) outperforming parental self-compassion (beta=.165; P=.009). eHealth self-efficacy moderated the cognitive empowerment pathway (beta=.124; P=.02) but not the self-compassion pathway. CONCLUSIONS: The findings suggest that generative AI engagement is associated with perceived nutrition-oriented feeding practices via 2 distinct indirect associations examined in this study: cognitive empowerment and parental self-compassion. These associations were strongest when mothers trusted the AI system and perceived its recommendations as fitting their child and household realities, indicating that the perceived value of AI in toddler feeding may lie less in algorithmic sophistication than in its capacity to build trust, fit context, and support maternal judgment. Because the outcome reflects maternal perception rather than observed feeding behavior or child nutrition outcomes, these findings should be interpreted as associational. They may nonetheless inform future research on AI-assisted feeding support that complements, rather than replaces, professional nutrition counseling. CI - (c) Lia Nur Amalina, Ferdi Antonio, Surya Adiwena, Dewi Wuisan, Roy Glenn Massie. Originally published in JMIR Pediatrics and Parenting (https://pediatrics.jmir.org). FAU - Amalina, Lia Nur AU - Amalina LN AUID- ORCID: 0009-0002-8791-4632 AD - Department of Hospital Administration, Graduate School of Management, Pelita Harapan University, Jl. Garnisun Dalam No. 8, RT 5, RW 4, Karet Semanggi, Jakarta, Jakarta Special Capital Region, 12930, Indonesia, 62 812-1010-676. FAU - Antonio, Ferdi AU - Antonio F AUID- ORCID: 0000-0002-1319-3732 AD - Department of Hospital Administration, Graduate School of Management, Pelita Harapan University, Jl. Garnisun Dalam No. 8, RT 5, RW 4, Karet Semanggi, Jakarta, Jakarta Special Capital Region, 12930, Indonesia, 62 812-1010-676. FAU - Adiwena, Surya AU - Adiwena S AUID- ORCID: 0009-0005-0198-4341 AD - Department of Hospital Administration, Graduate School of Management, Pelita Harapan University, Jl. Garnisun Dalam No. 8, RT 5, RW 4, Karet Semanggi, Jakarta, Jakarta Special Capital Region, 12930, Indonesia, 62 812-1010-676. FAU - Wuisan, Dewi AU - Wuisan D AUID- ORCID: 0000-0001-8550-3659 AD - Department of Hospital Administration, Graduate School of Management, Pelita Harapan University, Jl. Garnisun Dalam No. 8, RT 5, RW 4, Karet Semanggi, Jakarta, Jakarta Special Capital Region, 12930, Indonesia, 62 812-1010-676. FAU - Massie, Roy Glenn AU - Massie RG AUID- ORCID: 0009-0007-9980-8841 AD - Health Policy, National Research and Innovation Agency (BRIN), Jakarta, Indonesia. LA - eng PT - Journal Article DEP - 20260921 PL - Canada TA - JMIR Pediatr Parent JT - JMIR pediatrics and parenting JID - 101727244 PMC - PMC13592562 OTO - NOTNLM OT - Indonesia OT - cognitive empowerment OT - feeding behavior OT - generative artificial intelligence OT - health literacy OT - mothers OT - parental self-compassion OT - parenting OT - self-efficacy COIS- Conflicts of Interest: None declared. EDAT- 2026/09/21 17:47 MHDA- 2026/09/21 17:48 PMCR- 2026/09/21 CRDT- 2026/09/21 14:43 PHST- 2026/05/02 00:00 [received] PHST- 2026/08/04 00:00 [revised] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/09/21 17:48 [medline] PHST- 2026/09/21 17:47 [pubmed] PHST- 2026/09/21 14:43 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - v9i1e100061 [pii] AID - 100061 [pii] AID - 10.2196/100061 [doi] PST - epublish SO - JMIR Pediatr Parent. 2026 Sep 21;9:e100061. doi: 10.2196/100061. PMID- 42766014 OWN - NLM STAT- Publisher LR - 20260921 IS - 1433-8491 (Electronic) IS - 0940-1334 (Linking) DP - 2026 Sep 21 TI - Results of the validated German Perceived Stress Questionnaire (PSQ) from a large German cohort of healthy adults and different disease groups compared to historical reference values. LID - 10.1007/s00406-026-02379-8 [doi] AB - BACKGROUND: Reference values of the validated German Perceived Stress Questionnaire (PSQ) were published in 2005 for healthy adults and individuals with different clinical conditions. We compared historical values with PSQ from the large German cohort participating in "Risk Factors for COVID-19 Vaccine Failure study (RisCoin). METHODS: In late 2021, we enrolled 4115 adults: hospital employees or patients with inflammatory bowel disease (IBD) or psychiatric disorders with >/= 2 COVID-19 vaccinations. Participants completed extensive questionnaires including PSQ. Healthcare workers (HCW) were categorized as HCW-healthy or HCW-plus (any chronic medical condition). PSQ total and domain scores (worries, tension, joy, demands) were compared to reference values. Multivariable logistic regression identified factors associated with cohort-specific high scores (mean + 1SD). RESULTS: HCW-healthy (N = 1998, mean age +/- SD: 38 +/- 12 years) reached higher mean total PSQ scores than historical healthy individuals (36 +/- 18 vs. 33 +/- 17, respectively, p<0.001), but lower scores (40 +/- 19, p < 0.001) than HCW-plus (N = 1717, 43 +/- 13 years). Female HCW-healthy perceived higher stress than males, especially at younger age. Participants with IBD (N = 161, 45 +/- 15 years) exhibited lower scores than historical IBD patients (38 +/- 19 vs. 43 +/- 17, p < 0.001); psychiatric patients (N = 100, 41 +/- 15 years) showed the highest scores (60 +/- 19). Among HCW, female gender, frequent consumption of ready-to-eat meals/foods, and living with children were associated with higher, whereas regular physical activity and healthy dietary habits with lower PSQ scores. CONCLUSION: Assuming representativeness of our cohort, these PSQ data could serve as updated benchmark for future research. CI - (c) 2026. The Author(s). FAU - Adorjan, Kristina AU - Adorjan K AD - Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Center for International Health (CIH), LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - University Hospital of Psychiatry and Psychotherapy (UPZ), University of Bern, Bern, Switzerland. FAU - Raffel, Jannis AU - Raffel J AD - Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Zhelyazkova, Ana AU - Zhelyazkova A AUID- ORCID: 0000-0002-8085-5003 AD - Institut fur Notfallmedizin und Medizinmanagement (INM), LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Csollarova, Katarina AU - Csollarova K AD - Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Jebrini, Tarek AU - Jebrini T AD - Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Wratil, Paul R AU - Wratil PR AUID- ORCID: 0000-0003-0942-0637 AD - Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. FAU - Keppler, Oliver T AU - Keppler OT AD - Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. FAU - Tuschen, Marina AU - Tuschen M AD - Department of Anaesthesiology, Laboratory of Translational Research Stress and Immunity,LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Koletzko, Leandra AU - Koletzko L AD - Department of Medicine II, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Torok, Helga P AU - Torok HP AD - Department of Medicine II, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Chouker, Alexander AU - Chouker A AD - Department of Anaesthesiology, Laboratory of Translational Research Stress and Immunity,LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Koletzko, Sibylle AU - Koletzko S AD - Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. Sibylle.Koletzko@med.uni-muenchen.de. AD - Department of Pediatrics, Gastroenterology and Nutrition, School of Medicine Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland. Sibylle.Koletzko@med.uni-muenchen.de. FAU - Le Thi, Thu Giang AU - Le Thi TG AUID- ORCID: 0000-0002-2504-9551 AD - Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. thu_giang.le_thi@med.uni-muenchen.de. AD - Stiftung Kindergesundheit, c/o Dr. von Hauner Children's Hospital, LMU University Hospital, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. thu_giang.le_thi@med.uni-muenchen.de. CN - Members of RisCoin Study Group LA - eng PT - Journal Article DEP - 20260921 PL - Germany TA - Eur Arch Psychiatry Clin Neurosci JT - European archives of psychiatry and clinical neuroscience JID - 9103030 SB - IM OTO - NOTNLM OT - Chronic conditions OT - Collaborative care OT - Prospective study OT - Risk factors OT - Stress COIS- Declarations. Conflict of interest: The authors declare no competing interests. Informed consent statement: All the participants provided written informed consent prior to participation. Institutional review board statement: This study protocol was approved by the Ethics Committee of LMU Munich on September 21, 2021 (Project Number: 21-0839), with acceptance of amendments on February 22, 2022, and May 4, 2022. The data protection concept was approved by the LMU data protection officer on September 15, 2021, and the amendment for the second follow-up was approved on September 8, 2022. Clinical trial registration: "Risk factors for COVID-19 vaccine failure, "RisCoin", MainID: DRKS00026804, http://drks.de/search/en/trial/DRKS00026804 (Accessed on 18.07.2025). FIR - Osterman, A IR - Osterman A FIR - Badell Garcia, I IR - Badell Garcia I FIR - Huber, M IR - Huber M FIR - Wratil, P R IR - Wratil PR FIR - Adorjan, K IR - Adorjan K FIR - Gryaznova, A IR - Gryaznova A FIR - Jebrini, T IR - Jebrini T FIR - Kohl, P IR - Kohl P FIR - Jonge, S IR - Jonge S FIR - Neumeier, K IR - Neumeier K FIR - Koletzko, S IR - Koletzko S FIR - Koletzko, B IR - Koletzko B FIR - Kim-Helmuth, S IR - Kim-Helmuth S FIR - Hao, Y IR - Hao Y FIR - Horak, J IR - Horak J FIR - Le Thi, T G IR - Le Thi TG FIR - Puzek, B IR - Puzek B FIR - Schwerd, T IR - Schwerd T FIR - Torok, H P IR - Torok HP FIR - Koletzko, L IR - Koletzko L FIR - Breiteneicher, S IR - Breiteneicher S FIR - Csollarova, K IR - Csollarova K FIR - Chouker, A IR - Chouker A FIR - Tuschen, M IR - Tuschen M FIR - Biere, K IR - Biere K FIR - Wohrle, T IR - Wohrle T FIR - Matzel, S IR - Matzel S FIR - Horl, M IR - Horl M FIR - Moser, D IR - Moser D FIR - Hornung, V IR - Hornung V FIR - Rech, J IR - Rech J FIR - Ludwig, C IR - Ludwig C FIR - Hansbauer, L IR - Hansbauer L FIR - Zhelyazkova, A IR - Zhelyazkova A FIR - Klein, M IR - Klein M FIR - Volk, S IR - Volk S EDAT- 2026/09/21 17:47 MHDA- 2026/09/21 17:47 CRDT- 2026/09/21 11:04 PHST- 2026/03/26 00:00 [received] PHST- 2026/09/06 00:00 [accepted] PHST- 2026/09/21 17:47 [medline] PHST- 2026/09/21 17:47 [pubmed] PHST- 2026/09/21 11:04 [entrez] AID - 10.1007/s00406-026-02379-8 [pii] AID - 10.1007/s00406-026-02379-8 [doi] PST - aheadofprint SO - Eur Arch Psychiatry Clin Neurosci. 2026 Sep 21. doi: 10.1007/s00406-026-02379-8. PMID- 42764707 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20260923 IS - 1520-6300 (Electronic) IS - 1042-0533 (Print) IS - 1042-0533 (Linking) VI - 38 IP - 9 DP - 2026 Sep TI - Sleep Duration and Sun Exposure in Portuguese Children: Associations With Obesity Indicators. PG - e70333 LID - 10.1002/ajhb.70333 [doi] LID - e70333 AB - INTRODUCTION: Sleep duration, sun exposure, and obesity are important and potentially interconnected factors in child health. In this study, we aimed to analyze the associations between sleep duration, sun exposure, and obesity indicators in Portuguese children. METHODS: This cross-sectional study included 4755 children aged 3-10 years from public and private schools across Portugal. Parents reported children's sleep duration, sun exposure, screen time, active play, and physical activity using validated questionnaires. Trained professionals measured weight and height to calculate Body Mass Index (BMI) and assessed skinfold thickness to estimate body fat percentage (%BF). Multiple linear regression analyses, stratified by sex and adjusted for demographic, behavioral, and anthropometric factors, analyzed associations between sun exposure and sleep duration. RESULTS: In partially adjusted models (Model 1), negative associations persisted among boys, and positive associations emerged in girls for average sleep duration (beta = 2.11; 95% CI: 0.25 to 3.96; p = 0.026) and weekdays (beta = 2.40; 95% CI: 0.47 to 4.33; p = 0.015). In fully adjusted models (Model 2), the negative association remained only for boys on Sundays (beta = -4.57; 95% CI: -8.22 to -0.91; p = 0.014), with no significant associations in girls. CONCLUSIONS: Sun exposure exhibits modest, sex-specific associations with sleep duration in children. These findings emphasize the importance of considering behavioral and environmental factors when designing interventions to promote healthy sleep, support growth, and prevent childhood obesity. CI - (c) 2026 The Author(s). American Journal of Human Biology published by Wiley Periodicals LLC. FAU - Dos Santos, Elizabete A AU - Dos Santos EA AUID- ORCID: 0000-0001-9201-4095 AD - Research Centre for Anthropology and Health, Department of Life Sciences, University of Coimbra, Coimbra, Portugal. AD - Department of Nutrition, Paulista School of Medicine (EPM) of the Federal University of Sao Paulo (Unifesp), Sao Paulo, Brazil. FAU - Machado-Rodrigues, Aristides AU - Machado-Rodrigues A AUID- ORCID: 0000-0002-7169-8034 AD - Research Centre for Anthropology and Health, Department of Life Sciences, University of Coimbra, Coimbra, Portugal. AD - Faculty of Sport Sciences and Physical Education, University of Coimbra, Coimbra, Portugal. FAU - Rodrigues, Daniela AU - Rodrigues D AUID- ORCID: 0000-0002-4559-4303 AD - Research Centre for Anthropology and Health, Department of Life Sciences, University of Coimbra, Coimbra, Portugal. FAU - Silva, Maria-Raquel G AU - Silva MG AUID- ORCID: 0000-0001-8170-3119 AD - Research Centre for Anthropology and Health, Department of Life Sciences, University of Coimbra, Coimbra, Portugal. AD - FP-I3ID, FP-BHS, CEBIMED and Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal. AD - Comprehensive Health Research Centre, Nova Medical School, Nova University of Lisbon, Lisbon, Portugal. FAU - Nogueira, Helena AU - Nogueira H AUID- ORCID: 0000-0001-5724-3538 AD - Research Centre for Anthropology and Health, Department of Life Sciences, University of Coimbra, Coimbra, Portugal. AD - Department of Geography and Tourism, University of Coimbra, Coimbra, Portugal. FAU - Padez, Cristina AU - Padez C AUID- ORCID: 0000-0002-1967-3497 AD - Research Centre for Anthropology and Health, Department of Life Sciences, University of Coimbra, Coimbra, Portugal. LA - eng GR - PTDC/DTP-SAP/1520/2014/Fundacao para a Ciencia e a Tecnologia/ GR - COMPETE 2020, Portugal 2020, FEDER, and FCT/ PT - Journal Article PL - United States TA - Am J Hum Biol JT - American journal of human biology : the official journal of the Human Biology Council JID - 8915029 SB - IM MH - Humans MH - Portugal/epidemiology MH - *Sleep Duration MH - Male MH - Child MH - Female MH - Cross-Sectional Studies MH - Child, Preschool MH - *Sunlight MH - *Pediatric Obesity/epidemiology/etiology MH - *Sleep PMC - PMC13591200 OTO - NOTNLM OT - childhood obesity OT - children OT - pediatric public health OT - sleep duration OT - sun exposure COIS- The authors used ChatGPT (OpenAI) solely to assist with English-language editing and grammatical review. The tool was not used for data collection, data analysis, statistical procedures, interpretation of the findings, or generation of scientific conclusions. All AI-assisted revisions were critically reviewed and verified by the authors to ensure their accuracy, integrity, and consistency with the original scientific content. The authors take full responsibility for the final content of the manuscript. The authors declare no conflicts of interest. EDAT- 2026/09/21 05:34 MHDA- 2026/09/21 05:35 PMCR- 2026/09/21 CRDT- 2026/09/21 03:03 PHST- 2026/08/31 00:00 [revised] PHST- 2026/07/23 00:00 [received] PHST- 2026/09/09 00:00 [accepted] PHST- 2026/09/21 05:35 [medline] PHST- 2026/09/21 05:34 [pubmed] PHST- 2026/09/21 03:03 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - AJHB70333 [pii] AID - 10.1002/ajhb.70333 [doi] PST - ppublish SO - Am J Hum Biol. 2026 Sep;38(9):e70333. doi: 10.1002/ajhb.70333. PMID- 42763700 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260920 LR - 20260921 IS - 1726-9148 (Electronic) IS - 1726-913X (Print) IS - 1726-913X (Linking) VI - 24 IP - 2 DP - 2026 Apr 30 TI - Subclinical Diastolic Indices in Children with Type 1 Diabetes: A Cross-Sectional Comparative Study from Northern Iran. PG - e164686 LID - 10.5812/ijem-164686 [doi] LID - e164686 AB - BACKGROUND: Type 1 diabetes mellitus (T(1)DM) is common and can cause cardiac complications. Subclinical myocardial involvement, particularly impaired diastolic function, is a concern in pediatric patients with T(1)DM. OBJECTIVES: This study aimed to assess cardiac function, with a particular focus on diastolic indices, in children with T(1)DM. METHODS: In this cross-sectional comparative study, children aged 6 - 12 years were divided into two groups: a case group with T(1)DM and a control group of healthy children. Participants were recruited in 2023 from the Endocrinology Clinic at Amirkola Children's Hospital, Babol, Iran. All children underwent clinical evaluation, pubertal status assessment using the Marshall-Tanner criteria, electrocardiography, and echocardiography. RESULTS: A total of 150 children were included, comprising 50 children with T(1)DM and 100 controls. Overall, 52% of the participants were boys, and the mean age was 9.28 +/- 1.85 years. Late diastolic tissue velocity (A') was significantly higher in the T(1)DM group (P = 0.02), suggesting subclinical diastolic impairment. However, most other cardiac parameters, including all systolic indices, ejection fraction, fractional shortening, and electrocardiographic findings, were comparable between the groups (all P > 0.4). The T(1)DM group also had higher mean weight, height, body mass index, and body mass index percentiles (all P < 0.05). CONCLUSIONS: Children with T(1)DM exhibited subtle diastolic dysfunction, reflected by elevated A', whereas systolic function and other cardiac parameters were comparable with those in controls. Given the cross-sectional design, limited sample size, and potential confounding by body mass index and selection bias, these findings should be interpreted cautiously. The standardized single-center methodology supports internal validity; however, multicenter longitudinal studies with larger, z-score-adjusted samples are needed to confirm these results and clarify their clinical implications. CI - Copyright (c) 2026, Rezvani et al. FAU - Rezvani, Atoosa AU - Rezvani A AUID- ORCID: 0009-0006-8083-2203 AD - Student Research Committee, Babol University of Medical Sciences, Babol, Iran. FAU - Mirzaei Ilali, Hamidreza AU - Mirzaei Ilali H AUID- ORCID: 0000-0001-5238-2811 AD - Clinical Research Development Unit of Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, Iran. FAU - Ebrahimzade, Hadis AU - Ebrahimzade H AUID- ORCID: 0000-0003-0649-7268 AD - Clinical Research Development Unit of Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, Iran. FAU - Gholinia Ahangar, Hemmat AU - Gholinia Ahangar H AUID- ORCID: 0000-0003-0517-2429 AD - Health Research Institute, Babol University of Medical Sciences, Babol, Iran. FAU - Aghajanpour, Faeze AU - Aghajanpour F AUID- ORCID: 0000-0002-1698-6906 AD - Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. FAU - Alijanpour, Morteza AU - Alijanpour M AUID- ORCID: 0000-0002-0031-4718 AD - Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. LA - eng PT - Journal Article DEP - 20260424 PL - Netherlands TA - Int J Endocrinol Metab JT - International journal of endocrinology and metabolism JID - 101235597 PMC - PMC13589466 OTO - NOTNLM OT - Cardiovascular Disease OT - Child OT - Echocardiography OT - Iran OT - Type 1 Diabetes Mellitus COIS- There was no conflict of interest EDAT- 2026/09/20 05:43 MHDA- 2026/09/20 05:44 PMCR- 2026/04/24 CRDT- 2026/09/20 03:59 PHST- 2025/07/21 00:00 [received] PHST- 2026/02/17 00:00 [revised] PHST- 2026/02/24 00:00 [accepted] PHST- 2026/09/20 05:44 [medline] PHST- 2026/09/20 05:43 [pubmed] PHST- 2026/09/20 03:59 [entrez] PHST- 2026/04/24 00:00 [pmc-release] AID - 10.5812/ijem-164686 [doi] PST - epublish SO - Int J Endocrinol Metab. 2026 Apr 24;24(2):e164686. doi: 10.5812/ijem-164686. eCollection 2026 Apr 30. PMID- 42763449 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260920 LR - 20260921 IS - 2732-5121 (Electronic) IS - 2732-5121 (Linking) VI - 5 DP - 2025 TI - Moderate and vigorous physical activity show intensity specific familial and interpersonal association patterns in 9-12-year-olds: A cross-sectional DE-PASS study. PG - 331 LID - 10.12688/openreseurope.21538.4 [doi] LID - 331 AB - BACKGROUND: Research on children's physical activity often examines interpersonal associations but commonly aggregates MPA and VPA into a single MVPA outcome. This approach may obscure intensity-specific association patterns, particularly in intergenerational analyses. METHODS: This cross-sectional study used harmonized data from the European DE-PASS project, including children aged 9-12 years and one of their parents. Waist-worn accelerometry was used to assess MPA and VPA. Perceived parental, peer, and teacher support were measured using validated questionnaires. Intensity-specific associations between parent and child physical activity and between interpersonal support variables and children's activity were examined, including sex-stratified and socioeconomic sensitivity analyses. RESULTS: Parent-child associations differed by activity intensity. Parent-child resemblance was numerically larger for MPA than for VPA, although the difference between intensities was not statistically significant when formally compared; associations involving VPA were weaker and less consistent. Parental co-participation support showed a weak positive association (which did not survive correction for multiple testing) with children's MPA, whereas peer and teacher support showed limited or no associations with children's activity at either intensity. Sex-stratified analyses indicated similar MPA associations across boys and girls, while associations for VPA were not observed among girls. Aggregating MPA and VPA into MVPA may obscure these intensity-specific patterns. CONCLUSIONS: These findings indicate that interpersonal associations with children's physical activity differ by intensity and support examining MPA and VPA as intensity-specific outcomes in intergenerational analyses. Family-based approaches focusing on MPA may represent a pausible direction for future longitudinal and intervention research, while different strategies may be needed to address VPA. CI - Copyright: (c) 2026 Ferreira F et al. FAU - Ferreira, Flavio AU - Ferreira F AUID- ORCID: 0009-0001-0336-5561 AD - Lusofona University of Humanities and Technologies Faculty of Physical Education and Sport, Lisbon, Lisbon, Portugal. FAU - Dowd, Kieran AU - Dowd K AD - Department of Sport and Health Sciences, Technological University of the Shannon Midlands Midwest Faculty of Science and Health, Athlone, County Westmeath, Ireland. FAU - Coffey, Alan AU - Coffey A AD - Department of Sport and Health Sciences, Technological University of the Shannon Midlands Midwest Faculty of Science and Health, Athlone, County Westmeath, Ireland. FAU - Cardon, Greet AU - Cardon G AUID- ORCID: 0000-0003-4983-6557 AD - Department of Movement and Sports Sciences, Ghent University Faculty of Medicine and Health Sciences, Ghent, Flanders, Belgium. FAU - Iliano, Evelien AU - Iliano E AUID- ORCID: 0000-0002-8858-8333 AD - Department of Movement and Sports Sciences, Ghent University Faculty of Medicine and Health Sciences, Ghent, Flanders, Belgium. FAU - Dygryn, Jan AU - Dygryn J AD - Palacky University Olomouc Faculty of Physical Culture, Olomouc, Olomouc Region, Czech Republic. FAU - Pelclova, Jana AU - Pelclova J AD - Palacky University Olomouc Faculty of Physical Culture, Olomouc, Olomouc Region, Czech Republic. FAU - Labisa Palmeira, Antonio AU - Labisa Palmeira A AUID- ORCID: 0000-0001-6508-0599 AD - Lusofona University of Humanities and Technologies Faculty of Physical Education and Sport, Lisbon, Lisbon, Portugal. AD - Lusofona University of Humanities and Technologies Research Center on Sports Physical Education Exercise and Health, Lisbon, Lisbon, Portugal. AD - University of Porto Research Centre for Training Innovation and Intervention in Sport, Porto, Porto District, Portugal. FAU - de Geus, Eco J C AU - de Geus EJC AD - Department of Biological Psychology, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. LA - eng PT - Journal Article DEP - 20260902 PL - Belgium TA - Open Res Eur JT - Open research Europe JID - 9918230081006676 PMC - PMC13586601 OAB - This study looked at how parents, friends, and teachers might influence how active children aged 9 to 12 are in their daily lives. Physical activity is very important for children's growth and health. Doctors and health organizations recommend at least an hour of activity each day, yet most children around the world are not reaching this level. Being active helps children control their weight, strengthen their bones and muscles, and reduce the risk of health problems later in life. Researchers in Belgium, Czechia, and Ireland asked 181 families to take part. Both children and their parents wore activity trackers for eight days to measure how much moderate activity (like walking or playing outside) and vigorous activity (like running or sports) they did. Children also filled in questionnaires about how much support children felt from parents, friends, and teachers. The results showed that children were more active when their parents were active, especially for moderate activities. For example, if parents often walked or cycled, children were more likely to do the same. Vigorous activity, such as sports, showed weaker links to parents' behaviour and was only slightly connected to friends' encouragement. Teacher support was not found to make a difference in this study. These findings suggest that the best way to help children be more active is through family involvement, especially when parents take part in activities with their children. Friends' influence may become more important as children get older, but for this age group, parents are the strongest role models. This knowledge can help shape programs that aim to get children moving more often and more effectively. OABL- eng OTO - NOTNLM OT - Accelerometry; Physical activity intensity; Interpersonal Support; Parental modelling COIS- No competing interests were disclosed. EDAT- 2026/09/20 05:43 MHDA- 2026/09/20 05:44 PMCR- 2026/09/02 CRDT- 2026/09/20 03:45 PHST- 2026/07/31 00:00 [accepted] PHST- 2026/09/20 05:44 [medline] PHST- 2026/09/20 05:43 [pubmed] PHST- 2026/09/20 03:45 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - 10.12688/openreseurope.21538.4 [doi] PST - epublish SO - Open Res Eur. 2026 Sep 2;5:331. doi: 10.12688/openreseurope.21538.4. eCollection 2025. PMID- 42763108 OWN - NLM STAT- MEDLINE DCOM- 20260919 LR - 20260925 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 10 IP - 1 DP - 2026 Sep 19 TI - Happiness Toolkit in a paediatric outpatient setting for children with social, emotional, behavioural and/or mental health difficulties: a prospective cohort study. LID - 10.1136/bmjpo-2026-005011 [doi] LID - e005011 AB - OBJECTIVE: To evaluate the feasibility, acceptability and clinical outcomes of the Happiness Toolkit (HTK), a structured, low-intensity, family-delivered intervention for children aged 0-16 years screening positive for social, emotional, behavioural and/or mental health difficulties (SEMHD) in a paediatric outpatient setting. DESIGN: Single-site prospective cohort study; validated age-specific baseline screening, parent-reported outcomes at 6 weeks and 6 months. SETTING: General paediatric outpatient department, secondary hospital, Ireland. PARTICIPANTS: Consecutive paediatric outpatient attendees screening positive for SEMHD on the Ages and Stages Questionnaires: Social-Emotional, Second Edition (under 6 years) or Screen for Child Anxiety Related Emotional Disorders questionnaire (6-16 years) were enrolled for intervention. INTERVENTIONS: The HTK comprises six evidence-based components practised for 5 minutes morning and evening, introduced during routine outpatient consultation. MAIN OUTCOME MEASURES: Primary: consent rate, positive screen rate and 6-week response rate (feasibility); parental willingness to recommend (acceptability). Secondary: parent-reported functional changes at 6 weeks and 6 months, component uptake and adverse events. RESULTS: 240 of 277 families approached across 16 outpatient clinics consented (86.6%); 94 children screened positive for SEMHD (39.2%) and received the HTK. At 6-week follow-up (n=46; 48.9% response rate), 95.2% of parents reported a positive or very positive experience, 73.9% noted improved mood in their child, 43.5% reduced screen time and 37.0% improved sleep patterns. 97.8% would recommend, with no adverse events. At 6-month follow-up (n=13; 13.8% response rate), 61.5% reported sustained child mood improvement and 92.3% would still recommend. CONCLUSIONS: This study demonstrates strong feasibility and high parental acceptability for the HTK when embedded in routine paediatric outpatient care. Parent-reported improvements at 6 weeks and no adverse events at both time points support progression to a controlled evaluation. In Ireland, 4462 children await Child and Adolescent Mental Health Services and over 28 000 await primary care psychology; the HTK represents a promising, pragmatic early and bridging support for emerging SEMHD. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Eustace, Kate AU - Eustace K AUID- ORCID: 0000-0002-1537-9805 AD - Paediatrics, Midland Regional Hospital Mullingar, Mullingar, Ireland kateeustace1@gmail.com. FAU - McCrory, Sarah Alexandra AU - McCrory SA AUID- ORCID: 0009-0004-8525-4567 AD - Paediatrics, Midland Regional Hospital Mullingar, Mullingar, Ireland. FAU - Sharif, Farhana AU - Sharif F AUID- ORCID: 0009-0002-0051-8953 AD - Paediatrics, Midland Regional Hospital Mullingar, Mullingar, Ireland. AD - Paediatrics, RCSI, Dublin, Ireland. LA - eng PT - Journal Article DEP - 20260919 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - Prospective Studies MH - Child, Preschool MH - Adolescent MH - Feasibility Studies MH - *Mental Disorders/therapy/diagnosis MH - Infant MH - Surveys and Questionnaires MH - Parents/psychology MH - Ireland MH - *Child Behavior Disorders/therapy/diagnosis MH - *Happiness MH - Infant, Newborn PMC - PMC13599945 OTO - NOTNLM OT - Adolescent Health OT - Child Health OT - Child Psychiatry OT - Psychology OT - Qualitative research EDAT- 2026/09/19 23:52 MHDA- 2026/09/19 23:53 PMCR- 2026/09/19 CRDT- 2026/09/19 20:42 PHST- 2026/05/27 00:00 [received] PHST- 2026/08/28 00:00 [accepted] PHST- 2026/09/19 23:53 [medline] PHST- 2026/09/19 23:52 [pubmed] PHST- 2026/09/19 20:42 [entrez] PHST- 2026/09/19 00:00 [pmc-release] AID - 10.1136/bmjpo-2026-005011 [pii] AID - bmjpo-2026-005011 [pii] AID - 10.1136/bmjpo-2026-005011 [doi] PST - epublish SO - BMJ Paediatr Open. 2026 Sep 19;10(1):e005011. doi: 10.1136/bmjpo-2026-005011. PMID- 42761920 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260919 LR - 20260923 IS - 1178-7074 (Print) IS - 1178-7074 (Electronic) IS - 1178-7074 (Linking) VI - 19 DP - 2026 TI - Trajectories of Gestational Weight Gain During Early and Mid-Pregnancy and Their Association with Hypertensive Disorders of Pregnancy. PG - 634468 LID - 10.2147/IJGM.S634468 [doi] LID - 634468 AB - OBJECTIVE: To examine the association between trajectories of gestational weight gain (GWG) during early and mid-pregnancy and hypertensive disorders of pregnancy (HDP). A trajectory approach was used because total GWG or a single measurement cannot represent the timing and pattern of weight change. METHODS: This retrospective cohort included 11,278 women who attended the nutrition clinic and delivered at Fujian Provincial Maternity and Child Health Hospital, Fuzhou, China, between March 2014 and May 2018. Interval-specific GWG through 28 weeks was characterized using latent class growth modeling. Logistic regression estimated associations with HDP; the fully adjusted model included maternal age, pre-pregnancy body mass index, parity, platelet count, lactate dehydrogenase, and alanine aminotransferase. RESULTS: The current analysis used four reported GWG patterns: stable-low (Group 1; n=9,314, 82.6%), early-slow/mid-fast (Group 2; n=70, 0.6%), early-fast/mid-slow (Group 3; n=301, 2.7%), and moderate-growth (Group 4; n=1,593, 14.1%). Compared with Group 1, the fully adjusted odds of HDP were higher in Group 3 (odds ratio [OR]=2.285, 95% confidence interval [CI] 1.370-3.613; P=0.001) and Group 4 (OR=1.356, 95% CI 1.037-1.752; P=0.023), but not Group 2 (OR=1.084, 95% CI 0.176-3.528; P=0.911). CONCLUSION: In this hospital-based cohort, early- and mid-pregnancy GWG patterns were associated with HDP. The estimates for the smallest groups were imprecise, and the observational design does not establish causality or predictive utility. Studies with prospectively recorded HDP diagnosis timing and external validation are required before clinical use. CI - (c) 2026 Li et al. FAU - Li, Wenwen AU - Li W AD - Department of Gynecology II, Fujian Provincial Maternity and Children's Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China. FAU - Kang, Youhong AU - Kang Y AUID- ORCID: 0009-0001-7528-7152 AD - Obstetrics Department, Quanzhou Maternal and Child Health Hospital (Quanzhou Children's Hospital), Quanzhou, Fujian, People's Republic of China. FAU - Zhang, Huale AU - Zhang H AD - Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China. FAU - Tan, Wenxin AU - Tan W AD - Department of Obstetrics, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China. FAU - Li, Feng AU - Li F AD - Department of Gynecology II, Fujian Provincial Maternity and Children's Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China. FAU - Wu, Kunhai AU - Wu K AD - Blood Transfusion Department, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China. AD - Blood Transfusion Department, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China. FAU - Fang, Zhuanji AU - Fang Z AD - Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China. LA - eng PT - Journal Article DEP - 20260914 PL - New Zealand TA - Int J Gen Med JT - International journal of general medicine JID - 101515487 PMC - PMC13588108 OTO - NOTNLM OT - gestational weight gain OT - hypertensive disorders of pregnancy OT - latent class growth model OT - longitudinal trajectory OT - pregnancy COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/19 23:52 MHDA- 2026/09/19 23:53 PMCR- 2026/09/14 CRDT- 2026/09/19 06:25 PHST- 2026/07/08 00:00 [received] PHST- 2026/09/09 00:00 [accepted] PHST- 2026/09/19 23:53 [medline] PHST- 2026/09/19 23:52 [pubmed] PHST- 2026/09/19 06:25 [entrez] PHST- 2026/09/14 00:00 [pmc-release] AID - 634468 [pii] AID - 10.2147/IJGM.S634468 [doi] PST - epublish SO - Int J Gen Med. 2026 Sep 14;19:634468. doi: 10.2147/IJGM.S634468. eCollection 2026. PMID- 42761388 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260919 LR - 20260921 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 9 DP - 2026 Sep TI - Lifestyle Behaviors and Their Socio-Demographic Correlates Among University-Going Adolescents in Rawalpindi, Pakistan: A Cross-Sectional Study. PG - e73240 LID - 10.1002/hsr2.73240 [doi] LID - e73240 AB - OBJECTIVE: Adolescence is a critical period where lifestyle habits, including diet, physical exercise, sleep, and substance abuse, may have a significant influence on future health. The objective of this study was to determine adolescents' lifestyle behaviors and how they relate to socio-demographic characteristics. METHODS: The study included university-going older adolescents in Rawalpindi, Pakistan and employed a cross-sectional study design. Participants completed a validated questionnaire assessing lifestyle behaviors and their socio-demographic correlates, along with anthropometric measurements for BMI categorization. Chi-square test and multivariate logistic regression were used for analysis. RESULTS: The present study included 215 university-going older adolescents (mean age: 18.69 SD = 0.46 years); the majority (75.8%) were female participants, and 70.2% were urban inhabitants. The majority had a healthy BMI (68.8%) and ate three meals each day (90.7%), but less than 12% were physically active. Over a quarter reported not getting enough sleep. 28.4% of participants reported depressed symptoms; just 10.2% addressed their problems with a specialist. 9.8% used drugs (smoking), 20.9% vaped, and 25.6% began using before the age of 12. There were significant (p < 0.05) associations between lifestyle behaviors and socio-demographic characteristics such as age, BMI, and family type. Regression analysis showed BMI, residence, and parental education as key predictors of adolescent lifestyle. CONCLUSION: The findings revealed significant gaps in healthy lifestyle behaviors university-going older adolescents in Rawalpindi. CI - (c) 2026 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Rao, Meesha AU - Rao M AD - Department of Research and Development Armed Forces Institute of Cardiology/National Institute of Heart Diseases Rawalpindi Pakistan. FAU - Mahmood, Humaira AU - Mahmood H AUID- ORCID: 0000-0003-2341-6431 AD - School of Public Health Health Services Academy Islamabad Pakistan. FAU - Ahmad, Abdul Momin Rizwan AU - Ahmad AMR AUID- ORCID: 0000-0003-3499-902X AD - Department of Human Nutrition and Dietetics, NUST School of Health Sciences National University of Sciences and Technology (NUST) Islamabad Pakistan. AD - Department of Health Sciences University of York York UK. FAU - Zafar, Saira AU - Zafar S AUID- ORCID: 0009-0007-1850-5081 AD - School of Public Health Health Services Academy Islamabad Pakistan. FAU - Khalid, Hasnain AU - Khalid H AD - School of Management Xuzhou Medical University Xuzhou China. FAU - Siddiqui, Manaar Adil AU - Siddiqui MA AD - Department of Public Health, Armed Forces Postgraduate Medical Institute (AFPGMI) National University of Medical Sciences (NUMS) Rawalpindi Pakistan. FAU - Azad, Naseem AU - Azad N AD - Department of Public Health, Armed Forces Postgraduate Medical Institute (AFPGMI) National University of Medical Sciences (NUMS) Rawalpindi Pakistan. FAU - Abbasi, Attiya Najeeb AU - Abbasi AN AD - Department of Public Health, Armed Forces Postgraduate Medical Institute (AFPGMI) National University of Medical Sciences (NUMS) Rawalpindi Pakistan. FAU - Mohammadi, Nilab AU - Mohammadi N AUID- ORCID: 0009-0003-6376-0007 AD - Department of Curative Medicine Ghalib University Herat Afghanistan. LA - eng PT - Journal Article DEP - 20260917 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC13586443 OTO - NOTNLM OT - adolescents OT - lifestyle behaviors OT - physical activity OT - socio-demographic correlates OT - university students COIS- The authors declare that they do not have any conflict of interest. EDAT- 2026/09/19 23:52 MHDA- 2026/09/19 23:53 PMCR- 2026/09/17 CRDT- 2026/09/19 05:36 PHST- 2026/07/25 00:00 [received] PHST- 2026/08/27 00:00 [revised] PHST- 2026/09/05 00:00 [accepted] PHST- 2026/09/19 23:53 [medline] PHST- 2026/09/19 23:52 [pubmed] PHST- 2026/09/19 05:36 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - HSR273240 [pii] AID - 10.1002/hsr2.73240 [doi] PST - epublish SO - Health Sci Rep. 2026 Sep 17;9(9):e73240. doi: 10.1002/hsr2.73240. eCollection 2026 Sep. PMID- 42759561 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261013 IS - 1361-6579 (Electronic) IS - 0967-3334 (Linking) VI - 47 IP - 10 DP - 2026 Oct 13 TI - Improving sleep monitoring in athletes: a comparative evaluation of four automated sleep scoring algorithms on 204 polysomnography recordings. LID - 10.1088/1361-6579/aea9ea [doi] AB - Objective.Automated sleep scoring offers the potential for fast, precise, and cost-effective analysis. This study evaluated the accuracy, robustness, and clinical agreement of four algorithms against manual polysomnography (PSG) in athletes, and assessed how signal degradation and individual physiological traits affect automated scoring in ambulatory settings.Approach.Data from 75 healthy athletes (91.1% male, mean age 26.3 +/- 5.4 years, range [18-41], 204 PSG recordings) were retrospectively collected from studies conducted in our laboratory. Manual scoring was compared to four automated sleep staging algorithms: Luna, U-Sleep, Yet Another Spindle Algorithm (YASA), and Greifswald Sleep Stage Classifier (GSSC). Performance was evaluated on accuracy (per stage, macro and weightedF1), sensitivity (confusion matrices), robustness (signal quality:R(2); individual differences: beta coefficients) and clinical relevance (prediction of total sleep time (TST), sleep onset latency (SOL), wake after sleep onset (WASO) and sleep efficiency (SE)).Main results.All algorithms demonstrated strong agreement with manual scoring, with macroF1 scores of 0.76 (GSSC), 0.71 (U-Sleep), 0.70 (YASA), and 0.69 (Luna). GSSC was the most accurate and robust across sport, physiological, behavioral, and anthropometric variables. It showed minimal bias and narrow limits of agreement for TST, WASO and SE. GSSC was also the most resilient to signal degradation (marginalR(2)= 0.05), compared to YASA and Luna (0.06) and U-Sleep (0.24).Significance.Automated sleep staging algorithms demonstrated accuracy comparable to typical inter-rater agreement, supporting broader use in athletes. These algorithms could make PSG more accessible for both monitoring and research, providing deeper insights into sleep and its influence on athletic performance. CI - Creative Commons Attribution license. FAU - Crosbie, Flynn AU - Crosbie F AUID- ORCID: 0009-0006-1635-194X AD - Universite Paris Cite, VIFASOM (Vigilance fatigue Sommeil et Sante Publique), Paris, France. AD - INSEP (Institut National du Sport, de l'Expertise et de la Performance), Paris, France. FAU - Hanif, Umaer AU - Hanif U AUID- ORCID: 0000-0001-8288-5532 AD - Universite Paris Cite, VIFASOM (Vigilance fatigue Sommeil et Sante Publique), Paris, France. FAU - Aloulou, Anis AU - Aloulou A AUID- ORCID: 0000-0002-4124-3864 AD - Universite Paris Cite, VIFASOM (Vigilance fatigue Sommeil et Sante Publique), Paris, France. AD - APHP, Hotel-Dieu, Centre du Sommeil et de la Vigilance, Paris, France. FAU - Chauvineau, Maxime AU - Chauvineau M AUID- ORCID: 0000-0002-0690-8074 AD - Universite Paris Cite, VIFASOM (Vigilance fatigue Sommeil et Sante Publique), Paris, France. AD - APHP, Hotel-Dieu, Centre du Sommeil et de la Vigilance, Paris, France. FAU - Chennaoui, Mounir AU - Chennaoui M AUID- ORCID: 0000-0002-4409-813X AD - Universite Paris Cite, VIFASOM (Vigilance fatigue Sommeil et Sante Publique), Paris, France. AD - IRBA (Institut de Recherche biomedicale des armees), Bretigny, France. FAU - Nedelec, Mathieu AU - Nedelec M AUID- ORCID: 0000-0001-8095-9163 AD - INSEP (Institut National du Sport, de l'Expertise et de la Performance), Paris, France. FAU - Leger, Damien AU - Leger D AUID- ORCID: 0000-0003-1168-480X AD - Universite Paris Cite, VIFASOM (Vigilance fatigue Sommeil et Sante Publique), Paris, France. AD - APHP, Hotel-Dieu, Centre du Sommeil et de la Vigilance, Paris, France. LA - eng PT - Comparative Study PT - Evaluation Study PT - Journal Article DEP - 20261013 PL - England TA - Physiol Meas JT - Physiological measurement JID - 9306921 SB - IM MH - Humans MH - *Polysomnography/methods MH - *Algorithms MH - Male MH - Adult MH - Female MH - Automation MH - Adolescent MH - *Athletes MH - *Sleep/physiology MH - Young Adult MH - Sleep Stages MH - Sleep Duration MH - Signal Processing, Computer-Assisted OTO - NOTNLM OT - EEG OT - artificial intelligence OT - athletes OT - automated scoring OT - polysomnography OT - sleep staging EDAT- 2026/09/18 23:36 MHDA- 2026/10/13 17:37 CRDT- 2026/09/18 19:08 PHST- 2026/05/09 00:00 [received] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/10/13 17:37 [medline] PHST- 2026/09/18 23:36 [pubmed] PHST- 2026/09/18 19:08 [entrez] AID - 10.1088/1361-6579/aea9ea [doi] PST - epublish SO - Physiol Meas. 2026 Oct 13;47(10). doi: 10.1088/1361-6579/aea9ea. PMID- 42756052 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260918 LR - 20260919 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Physical activity and health-related quality of life among Chinese adolescents: a cross-sectional statistical path model involving sleep disturbance and depressive symptoms. PG - 1954434 LID - 10.3389/fped.2026.1954434 [doi] LID - 1954434 AB - OBJECTIVE: Physical activity (PA) is positively associated with health-related quality of life (HRQoL) in adolescents, while sleep disturbance and depressive symptoms are also closely related to both PA and HRQoL. However, relatively few studies have examined these factors simultaneously, particularly among Chinese adolescents. This study examined the association between PA and HRQoL and assessed the separate and serial indirect associations involving sleep disturbance and depressive symptoms. METHODS: A cross-sectional survey was conducted among 2,202 secondary-school students from 12 schools in China. Participants completed validated self-report measures of PA, sleep disturbance, depressive symptoms, and HRQoL. Pearson correlations were used to examine bivariate associations, and a serial multiple-mediator model (PROCESS Model 6) was applied to estimate direct and indirect associations. Statistical uncertainty was evaluated using 5,000 bootstrap resamples and bias-corrected 95% confidence intervals (CIs). RESULTS: Higher PA was associated with lower sleep disturbance and depressive symptoms and with better HRQoL. Sleep disturbance was positively associated with depressive symptoms, whereas both sleep disturbance and depressive symptoms were inversely associated with HRQoL. The standardized total association between PA and HRQoL was 0.324 [95% CI (0.288, 0.358)], of which 0.095 was statistically accounted for by the combined indirect associations. Significant specific indirect associations were observed through sleep disturbance alone [beta = 0.032, 95% CI (0.019, 0.046)], depressive symptoms alone [beta = 0.046, 95% CI (0.034, 0.058)], and the sequential pathway involving sleep disturbance followed by depressive symptoms [beta = 0.017, 95% CI (0.013, 0.022)]. The direct PA-HRQoL association remained significant after both statistical mediators were included [beta = 0.229, 95% CI (0.191, 0.265)]. CONCLUSIONS: PA, sleep disturbance, depressive symptoms, and HRQoL were closely interconnected among Chinese adolescents. Sleep- and mood-related factors statistically accounted for part of the positive association between PA and HRQoL, with depressive symptoms showing the largest specific indirect association. These findings support considering PA, sleep health, and emotional well-being within an integrated adolescent health framework. Because all variables were measured concurrently, the observed indirect associations should not be interpreted as evidence of temporal or causal mediation. CI - (c) 2026 Liu. FAU - Liu, Mengxuan AU - Liu M AD - School of Physical Education, Jiangxi Institute of Technology, Nanchang, China. LA - eng PT - Journal Article DEP - 20260903 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13582418 OTO - NOTNLM OT - China OT - adolescents OT - depressive symptoms OT - health-related quality of life OT - physical activity OT - sleep disturbance OT - statistical association COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/18 12:25 MHDA- 2026/09/18 12:26 PMCR- 2026/09/03 CRDT- 2026/09/18 06:37 PHST- 2026/07/31 00:00 [received] PHST- 2026/08/19 00:00 [revised] PHST- 2026/08/20 00:00 [accepted] PHST- 2026/09/18 12:26 [medline] PHST- 2026/09/18 12:25 [pubmed] PHST- 2026/09/18 06:37 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - 10.3389/fped.2026.1954434 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 3;14:1954434. doi: 10.3389/fped.2026.1954434. eCollection 2026. PMID- 42754327 OWN - NLM STAT- MEDLINE DCOM- 20260917 LR - 20261016 IS - 1875-7855 (Electronic) IS - 0079-6123 (Linking) VI - 301 DP - 2026 TI - Neuroscience and biomarkers of sleep in preterm and term infants: From state organization to clinical translation. PG - 93-206 LID - S0079-6123(26)00027-0 [pii] LID - 10.1016/bs.pbr.2026.08.001 [doi] AB - Infant sleep, viewed across the preterm-to-term continuum, is best understood not as a behavioral backdrop but as a developing neurobiological control system whose state organization offers a clinically accessible window onto central nervous system maturation. In this chapter we synthesize evidence on sleep across three contexts - the NICU, the post-discharge period, and community samples - and across three nested levels of organization: macro-architectural cycling between active, quiet, and indeterminate sleep; microstructural EEG features such as spindles, slow oscillations, and graphoelements; and the gradual emergence of circadian timing. We argue that infant sleep functions simultaneously as a mediator of brain development, a moderator of early vulnerability, and a marker of neurodevelopmental risk - a triple role that justifies treating sleep assessment as a core component of neonatal care rather than a supplementary concern. Yet the path from biomarker to bedside is far from frictionless. We examine the strengths and inferential limits of polysomnography, conventional and amplitude-integrated EEG, behavioral state coding, actigraphy, and autonomic-cardiorespiratory metrics, and we develop a reliability-validity-specificity framework for evaluating candidate biomarkers against the moving baselines of maturation, medication, illness, and environment. Throughout, we flag where current evidence supports causal mechanism, where it is merely correlational, and where the direction of effect may be bidirectional. The chapter closes with a three-step clinician-researcher bridge - assess, contextualize, decide - designed to translate multimodal sleep data into age-corrected, context-aware clinical decisions. Sleep, properly read, is not a research curiosity. It is a routine instrument of neurodevelopmental care. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Abouseif, Nada AU - Abouseif N AD - Canadian University Dubai, Dubai, United Arab Emirates. FAU - Papatzikis, Efthymios AU - Papatzikis E AD - Canadian University Dubai, Dubai, United Arab Emirates; "Panagiotis and Aglaia Kyriakou" Children's Hospital, Athens, Greece. Electronic address: e.papatzikis@cud.ac.ae. LA - eng PT - Journal Article PT - Review DEP - 20260902 PL - Netherlands TA - Prog Brain Res JT - Progress in brain research JID - 0376441 RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Sleep/physiology MH - *Infant, Premature/physiology MH - Biomarkers MH - Infant, Newborn MH - Electroencephalography MH - Infant MH - Neurodevelopment MH - *Brain/physiology/growth & development MH - Polysomnography OTO - NOTNLM OT - EEG maturation OT - Infant sleep OT - Neonatal neurodevelopment OT - Preterm infants OT - Sleep biomarkers OT - Sleep state organization EDAT- 2026/09/17 23:34 MHDA- 2026/09/17 23:35 CRDT- 2026/09/17 20:56 PHST- 2026/09/17 23:35 [medline] PHST- 2026/09/17 23:34 [pubmed] PHST- 2026/09/17 20:56 [entrez] AID - S0079-6123(26)00027-0 [pii] AID - 10.1016/bs.pbr.2026.08.001 [doi] PST - ppublish SO - Prog Brain Res. 2026;301:93-206. doi: 10.1016/bs.pbr.2026.08.001. Epub 2026 Sep 2. PMID- 42752631 OWN - NLM STAT- MEDLINE DCOM- 20260917 LR - 20260922 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 9 DP - 2026 TI - Machine learning and deep learning-based prediction of hypertension and analysis of its major risk factors in Bangladesh. PG - e0358471 LID - 10.1371/journal.pone.0358471 [doi] LID - e0358471 AB - BACKGROUND: Hypertension is a leading cause of cardiovascular morbidity and mortality in Bangladesh. This study examined its prevalence, risk factors, and predictive modeling using machine learning (ML) and deep learning (DL) approaches. METHOD: We analyzed cross-sectional data from the 2022 Bangladesh Demographic and Health Survey, which included 14,283 adults (>/=18 years). Prevalence was estimated, chi-square tests assessed associations, and four ML models (weighted logistic regression, random forest, extreme gradient boosting, light gradient boosting machine) and two DL models (TabNet, and multi-layer perceptron) were applied to predict hypertension risk. Model performance was evaluated using accuracy, precision, recall, specificity, F1 score, and area under the receiver operating characteristics curve and precision-recall curve. RESULTS: Overall prevalence was 18.04% (95% CI: 17.2%-18.9%), higher among women (18.87%) than men (16.97%). The chi-square test suggests that hypertension was significantly associated with age, BMI, diabetes, wealth index, education, household size, and region (p < 0.05). Among the machine learning and deep learning models, weighted logistic regression (WLR) achieved the highest accuracy (0.817), precision (0.444), specificity (0.981), AUC-ROC (0.751), and AUC-PR (0.357). However, WLR exhibited low recall (0.070). In contrast, the random forest (RF) model achieved the highest recall (0.687) and F1-score (0.460) on the test data, indicating greater sensitivity in identifying individuals with hypertension. Additionally, age, BMI, sex, family size, and educational level were identified as the most important predictors among the variables included in the study. CONCLUSION: Hypertension is common in Bangladesh, with higher prevalence in women and significant association with socio-demographic determinants. Although WLR demonstrated the highest accuracy, precision, specificity, and AUC-PR, its low recall limits its utility for identifying individuals with hypertension. RF may be more suitable for public health applications because of its higher recall and F1-score; however, further external validation and assessment of its clinical utility are required before implementation. CI - Copyright: (c) 2026 Chandra et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Chandra, Shawrab AU - Chandra S AD - Department of Statistics and Data Science, University of Barishal, Barishal, Bangladesh. FAU - Molla, Md Maeen AU - Molla MM AUID- ORCID: 0009-0000-9315-7338 AD - Department of Statistics, Pirojpur Science and Technology University, Pirojpur, Bangladesh. FAU - Islam, Samiul AU - Islam S AD - Department of Statistics and Data Science, University of Rajshahi, Rajshahi, Bangladesh. FAU - Rahaman, Md Matiur AU - Rahaman MM AUID- ORCID: 0000-0001-9799-9364 AD - Department of Statistics, Faculty of Science, Gopalganj Science and Technology University, Gopalganj, Bangladesh. FAU - Ali, Mohammad AU - Ali M AUID- ORCID: 0000-0002-0279-1972 AD - Statistics Discipline, Khulna University, Khulna, Bangladesh. FAU - Ali, Md Ayub AU - Ali MA AUID- ORCID: 0000-0002-5113-0054 AD - Department of Statistics and Data Science, University of Barishal, Barishal, Bangladesh. LA - eng PT - Journal Article DEP - 20260917 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - *Hypertension/epidemiology/diagnosis MH - Humans MH - Female MH - *Deep Learning MH - Bangladesh/epidemiology MH - Risk Factors MH - Male MH - Adult MH - Predictive Learning Models MH - Middle Aged MH - Random Forest MH - Cross-Sectional Studies MH - Prevalence MH - Boosting Machine Learning Algorithms MH - *Machine Learning MH - Prediction Algorithms MH - Young Adult MH - Adolescent MH - Classification Algorithms MH - Logistic Models MH - ROC Curve PMC - PMC13585235 COIS- The authors have declared that no competing interests exist. EDAT- 2026/09/17 18:32 MHDA- 2026/09/17 18:33 PMCR- 2026/09/17 CRDT- 2026/09/17 15:52 PHST- 2025/10/16 00:00 [received] PHST- 2026/09/01 00:00 [accepted] PHST- 2026/09/17 18:33 [medline] PHST- 2026/09/17 18:32 [pubmed] PHST- 2026/09/17 15:52 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - PONE-D-25-55897 [pii] AID - 10.1371/journal.pone.0358471 [doi] PST - epublish SO - PLoS One. 2026 Sep 17;21(9):e0358471. doi: 10.1371/journal.pone.0358471. eCollection 2026. PMID- 42752205 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261024 IS - 2165-0497 (Electronic) IS - 2165-0497 (Linking) VI - 14 IP - 10 DP - 2026 Oct 6 TI - Multi-omics insights into growth impairment mechanisms in children with persistent diarrhea. PG - e0390525 LID - 10.1128/spectrum.03905-25 [doi] LID - e03905-25 AB - This study aimed to elucidate the key mechanisms underlying short stature with pediatric persistent diarrhea in children (PDC) and to propose an integrated model linking the butyrate-producing gut microbial niche, short-chain fatty acids (SCFAs), Th17/Treg balance, the growth hormone-insulin-like growth factor 1 (GH-IGF-1) axis, and growth regulation. Samples from healthy controls (HCs), PDC patients without short stature (PDC-NS), and PDC patients with short stature (PDC-S) were analyzed using multi-omics profiling and machine learning-based predictive modeling. The results showed that PDC-S patients exhibited disruption of core butyrate-producing bacterial communities and related metabolic pathways, markedly reduced fecal butyrate levels, systemic Th17/Treg imbalance characterized by a pro-inflammatory state, and dual suppression of receptor- and ligand-level components of the GH-IGF-1 axis. Multi-omics machine learning identified a five-factor risk prediction panel composed of metabolic, immune, and endocrine markers, while causal inference further established butyrate as a central regulator of growth. Mouse experiments further validated that combined intervention with butyrate, Faecalibacterium prausnitzii, and recombinant human growth hormone (rhGH) ameliorated growth retardation. Overall, this study proposes a precision therapeutic strategy based on butyrate and GH co-intervention, providing new mechanistic insights and translational tools for PDC-associated short stature. IMPORTANCE: The research conducted in this study holds significant implications for improving the understanding and treatment of stunted growth with persistent diarrhea in children (PDC). By unraveling the intricate pathways linking gut microbiota, immune responses, and growth hormone regulation, the study sheds light on the underlying mechanisms contributing to stunting in these vulnerable populations. The identification of key factors, such as butyrate-producing bacteria and the Th17/Treg balance, not only enhances our comprehension of PDC-related growth impairment but also offers a promising avenue for targeted interventions. The proposed integrated mechanistic model and intervention strategy pave the way for precision therapies tailored to address the specific biological mechanisms at play, potentially leading to more effective and personalized treatments for children suffering from PDC-associated stunting. FAU - Shen, Jian AU - Shen J AUID- ORCID: 0000-0001-9332-5389 AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Yan, Junle AU - Yan J AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Yuan, Ying AU - Yuan Y AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Le, Lilin AU - Le L AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Xu, Juan AU - Xu J AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Chen, Bailu AU - Chen B AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Liu, Xiaoying AU - Liu X AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Chen, Huijie AU - Chen H AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Chen, Lijun AU - Chen L AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Yi, Meixiang AU - Yi M AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Lyu, Jiajia AU - Lyu J AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Diao, Jun AU - Diao J AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Zhang, Xinlin AU - Zhang X AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Zhao, Yinqiu AU - Zhao Y AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Chen, Jingru AU - Chen J AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 LA - eng GR - E4-H200210199/Shanghai University of Traditional Chinese Medicine General Program/ GR - ZY(2021-2023)-0206-03/Shanghai Municipal Health Commission Three-Year Action Plan for TCM Development/ PT - Journal Article DEP - 20260917 PL - United States TA - Microbiol Spectr JT - Microbiology spectrum JID - 101634614 RN - 0 (Fatty Acids, Volatile) RN - 0 (Butyrates) RN - 67763-96-6 (Insulin-Like Growth Factor I) RN - 12629-01-5 (Human Growth Hormone) RN - 9002-72-6 (Growth Hormone) SB - IM MH - Humans MH - *Diarrhea/microbiology/complications/metabolism MH - Animals MH - Multiomics MH - Child MH - Fatty Acids, Volatile/metabolism MH - Butyrates/metabolism MH - *Growth Disorders/microbiology/metabolism MH - Insulin-Like Growth Factor I/metabolism MH - Male MH - Mice MH - Female MH - Feces/microbiology/chemistry MH - Gastrointestinal Microbiome MH - Child, Preschool MH - T-Lymphocytes, Regulatory/immunology MH - Human Growth Hormone/metabolism MH - Th17 Cells/immunology MH - Faecalibacterium prausnitzii/physiology MH - Machine Learning MH - Growth Hormone MH - Bacteria/classification/genetics/isolation & purification/metabolism PMC - PMC13689471 OTO - NOTNLM OT - T helper 17 cells/regulatory T-cell balance OT - butyrate OT - growth hormone-insulin-like growth factor 1 axis OT - machine learning OT - multi-omics OT - persistent diarrhea in children OT - short-chain fatty acids OT - stunting COIS- The authors declare no conflict of interest. EDAT- 2026/09/17 18:33 MHDA- 2026/10/07 05:31 PMCR- 2026/09/17 CRDT- 2026/09/17 15:30 PHST- 2026/10/07 05:31 [medline] PHST- 2026/09/17 18:33 [pubmed] PHST- 2026/09/17 15:30 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - spectrum03905-25 [pii] AID - spectrum.03905-25 [pii] AID - 10.1128/spectrum.03905-25 [doi] PST - ppublish SO - Microbiol Spectr. 2026 Oct 6;14(10):e0390525. doi: 10.1128/spectrum.03905-25. Epub 2026 Sep 17. PMID- 42751864 OWN - NLM STAT- MEDLINE DCOM- 20260917 LR - 20260923 IS - 1365-2060 (Electronic) IS - 0785-3890 (Print) IS - 0785-3890 (Linking) VI - 58 IP - 1 DP - 2026 Dec TI - Association of body mass index with postoperative pulmonary complications and potential explanatory pathways in paediatric scoliosis correction surgery: a multicentre cohort study. PG - 2731716 LID - 10.1080/07853890.2026.2731716 [doi] LID - 2731716 AB - BACKGROUND: Postoperative pulmonary complications (PPCs) contribute substantially to morbidity after paediatric scoliosis correction surgery, but the relationship between preoperative body mass index (BMI) and PPCs remains uncertain. We evaluated this association and explored potential explanatory pathways and the incremental predictive value of BMI. METHODS: This retrospective cohort study included 1,165 patients from three Chinese tertiary hospitals. Associations between BMI and the composite PPC outcome were evaluated using multivariable regression. An orthogonalized causal forest estimated the average partial effect of continuous BMI on PPC probability, and variation in model-derived partial-effect predictions across sex and preoperative Cobb-angle strata was examined descriptively. Exploratory pathway analyses considered the Prognostic Nutritional Index (PNI), intraoperative blood loss, and fusion levels. At the completion of surgery, the incremental predictive value of BMI was assessed using an elastic-net model developed in centres 1 and 3 and externally validated in centre 2. RESULTS: PPCs occurred in 321 patients (27.55%). In the primary preoperative-adjusted model, each 1-kg/m(2) higher BMI was associated with lower odds of PPCs (aOR, 0.87; 95% CI, 0.83-0.91; p < 0.001). A secondary exploratory perioperative-adjusted model yielded a similar estimate (aOR, 0.85; 95% CI, 0.81-0.89; p < 0.001). Compared with normal weight, thinness was associated with higher odds of PPCs (aOR, 4.26; 95% CI, 2.74-6.67; p < 0.001), whereas overweight was associated with lower odds (aOR, 0.57; 95% CI, 0.34-0.91; p = 0.022). The causal forest yielded an inverse average partial-effect estimate for BMI (-0.031; 95% CI, -0.037 to -0.025; p < 0.001). Exploratory pathway analyses suggested small indirect components through PNI, blood loss, and fusion levels. Adding BMI increased the external-validation AUC from 0.658 to 0.703 (p < 0.001), representing a modest improvement in discrimination. CONCLUSIONS: Higher preoperative BMI was associated with lower odds of PPCs, with a concordant inverse causal-forest estimate under its identification assumptions. Low BMI or thinness may serve as a preoperative risk marker, while the examined pathways accounted for only small proportions of the association. At the end-of-surgery prediction time point, adding BMI provided modest incremental predictive value, although the model's external performance was modest and further prospective validation is required. FAU - Shi, Weihai AU - Shi W AD - Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. AD - Medical School of Nanjing University, Nanjing, China. FAU - Zhu, Shouqiang AU - Zhu S AD - Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. AD - Medical School of Nanjing University, Nanjing, China. FAU - Wang, Yan AU - Wang Y AD - Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. AD - Drum Tower Clinical Medical School, Nanjing Medical University, Nanjing, China. FAU - Sun, Yanhua AU - Sun Y AD - Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. FAU - Zheng, Zhiying AU - Zheng Z AD - Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. AD - Medical School of Nanjing University, Nanjing, China. FAU - Liu, Peiyu AU - Liu P AD - Department of Operating Room, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. FAU - Zhang, Ruocui AU - Zhang R AD - Post-Anesthesia Care Unit, Department of Anesthesiology and Surgery, Nanjing Drum Tower Hospital, Nanjing, China. FAU - Xia, Tianjiao AU - Xia T AD - Medical School of Nanjing University, Nanjing, China. FAU - Ma, Lulu AU - Ma L AD - Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, China. FAU - Li, Min AU - Li M AUID- ORCID: 0000-0003-4853-4258 AD - Department of Anesthesiology, Peking University Third Hospital, Beijing, China. FAU - Bo, Jinhua AU - Bo J AD - Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. FAU - Gu, Xiaoping AU - Gu X AD - Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. AD - Medical School of Nanjing University, Nanjing, China. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260917 PL - England TA - Ann Med JT - Annals of medicine JID - 8906388 SB - IM MH - Humans MH - *Scoliosis/surgery MH - Female MH - *Body Mass Index MH - Retrospective Studies MH - *Postoperative Complications/epidemiology/etiology MH - Male MH - Child MH - *Lung Diseases/etiology/epidemiology MH - Adolescent MH - China/epidemiology MH - Spinal Fusion/adverse effects MH - Risk Factors MH - Blood Loss, Surgical/statistics & numerical data PMC - PMC13587573 OTO - NOTNLM OT - Body mass index OT - paediatric scoliosis OT - postoperative pulmonary complications OT - scoliosis surgery COIS- No potential conflict of interest was reported by the authors. EDAT- 2026/09/17 15:37 MHDA- 2026/09/17 15:38 PMCR- 2026/09/17 CRDT- 2026/09/17 07:27 PHST- 2026/09/17 15:38 [medline] PHST- 2026/09/17 15:37 [pubmed] PHST- 2026/09/17 07:27 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - 2731716 [pii] AID - 10.1080/07853890.2026.2731716 [doi] PST - ppublish SO - Ann Med. 2026 Dec;58(1):2731716. doi: 10.1080/07853890.2026.2731716. Epub 2026 Sep 17. PMID- 42744207 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261023 IS - 1532-3064 (Electronic) IS - 0954-6111 (Linking) VI - 263 DP - 2026 Nov TI - Identification of modifiable risk factors to prevent atopic wheeze in infants born to mothers with asthma: a cohort study. PG - 109154 LID - S0954-6111(26)00523-8 [pii] LID - 10.1016/j.rmed.2026.109154 [doi] AB - OBJECTIVE: Maternal asthma is the leading risk factor for children developing wheeze and allergic disease in early life. We aimed to describe atopic phenotypes in infants of mothers with asthma and assess which early-life factors were associated with these phenotypes. METHODS: Participants were part of the Breathing for Life Trial Birth Cohort, which recruited pregnant women with asthma prior to 23 weeks gestation (n = 549). Parents completed a validated questionnaire about their child's wheeze requiring healthcare utilization (hospitalization, emergency department visits, consultant referral and primary care visits for wheeze, asthma medication use), respiratory infections, eczema and rhinitis at 12 months of age. Latent class analysis was used to identify the atopic phenotypes among infants. Logistic regression assessed early-life risk factors including maternal characteristics, perinatal factors and environmental exposures. RESULTS: Three phenotypes were identified: low-atopy/low-wheeze (35.2%), atopic mild-wheeze (38.6%) and atopic high-wheeze (26.2%). Maternal obesity (aOR 3.22 95% CI 1.90, 5.44), smoking in pregnancy (aOR 2.60 95%CI 1.36, 4.97), asthma exacerbations in pregnancy (aOR 1.98 95%CI 1.30, 3.02), preterm birth (aOR 2.50 1.34, 4.66), and NICU admission (aOR 2.71 95%CI 1.14, 6.46) were associated with atopic high-wheeze compared to low-atopy/low-wheeze. Maternal obesity (aOR 2.02 95%CI 1.26, 3.24) and smoking in pregnancy (aOR 2.55 95%CI 1.37, 4.72) were associated with atopic mild-wheeze compared to low-atopy/low-wheeze. CONCLUSION: Multiple modifiable factors (maternal obesity, smoking and maternal asthma exacerbations) and adverse birth outcomes are associated with the severity of wheeze in infants of mothers with asthma, providing an opportunity for intervention to prevent later childhood asthma. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Liu, Jihong AU - Liu J AD - Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. FAU - Brew, Bronwyn K AU - Brew BK AD - School of Medicine and Public Health, University of Newcastle, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, Newcastle, NSW, Australia. Electronic address: bronwyn.brew@newcastle.edu.au. FAU - Zhao, Xingpei AU - Zhao X AD - Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. FAU - Collison, Adam AU - Collison A AD - School of Medicine and Public Health, University of Newcastle, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, Newcastle, NSW, Australia. FAU - Jensen, Megan E AU - Jensen ME AD - School of Medicine and Public Health, University of Newcastle, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, Newcastle, NSW, Australia. FAU - Mattes, Joerg AU - Mattes J AD - School of Medicine and Public Health, University of Newcastle, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, Newcastle, NSW, Australia; Department of Respiratory Medicine, John Hunter Children's Hospital, Newcastle, NSW, Australia. FAU - Robinson, Paul D AU - Robinson PD AD - Children's Health and Environment Program, Child Health Research Centre, University of Queensland, QLD, Australia; Department of Respiratory Medicine, Queensland Children's Hospital, QLD, Australia. FAU - Sly, Peter D AU - Sly PD AD - Children's Health and Environment Program, Child Health Research Centre, University of Queensland, QLD, Australia. FAU - Gibson, Peter G AU - Gibson PG AD - School of Medicine and Public Health, University of Newcastle, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, Newcastle, NSW, Australia; Department of Respiratory & Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia. FAU - Murphy, Vanessa E AU - Murphy VE AD - School of Medicine and Public Health, University of Newcastle, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, Newcastle, NSW, Australia. LA - eng PT - Journal Article DEP - 20260915 PL - England TA - Respir Med JT - Respiratory medicine JID - 8908438 SB - IM MH - Humans MH - Female MH - *Asthma/complications/epidemiology MH - *Respiratory Sounds/etiology MH - Pregnancy MH - Risk Factors MH - Infant MH - Adult MH - *Prenatal Exposure Delayed Effects/prevention & control MH - Cohort Studies MH - Smoking/adverse effects MH - Infant, Newborn MH - Phenotype MH - *Pregnancy Complications/epidemiology MH - Male MH - Developmental Origins of Health and Disease MH - Mothers OTO - NOTNLM OT - Asthma OT - Infant OT - Maternal OT - Obesity OT - Phenotypes OT - Smoking OT - Wheeze COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Bronwyn Brew reports financial support was provided by National Health and Medical Research Council. Vanessa Murphy reports financial support was provided by Australian Government Medical Research Future Fund. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/15 23:35 MHDA- 2026/10/23 23:31 CRDT- 2026/09/15 19:21 PHST- 2026/03/19 00:00 [received] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/09 00:00 [accepted] PHST- 2026/10/23 23:31 [medline] PHST- 2026/09/15 23:35 [pubmed] PHST- 2026/09/15 19:21 [entrez] AID - S0954-6111(26)00523-8 [pii] AID - 10.1016/j.rmed.2026.109154 [doi] PST - ppublish SO - Respir Med. 2026 Nov;263:109154. doi: 10.1016/j.rmed.2026.109154. Epub 2026 Sep 15. PMID- 42740390 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260917 IS - 2314-6753 (Electronic) IS - 2314-6745 (Print) VI - 2026 IP - 1 DP - 2026 TI - Olfactory Performance of Children and Adolescents With Type 1 Diabetes: Relationship to Diabetes Duration and Glycemic Control. PG - e8415282 LID - 10.1155/jdr/8415282 [doi] LID - 8415282 AB - BACKGROUND/OBJECTIVES: Olfactory dysfunction is increasingly recognized as a complication of diabetes that negatively impacts eating behavior and quality of life. This study investigates olfactory function in adolescents with Type 1 diabetes and evaluates the impact of disease duration and long-term glycemic control (mean HbA1c) on olfactory performance. METHODS: Olfactory function was assessed using the validated "Sniffin' Sticks" test, which evaluates odor threshold, discrimination, and identification to generate a composite TDI score for diagnosing hyposmia (TDI < 30.75). RESULTS: Hyposmia was identified in 30% of adolescents with Type 1 diabetes, whereas none exhibited anosmia. Overall olfactory performance (TDI scores) did not differ significantly by diabetes duration, age, sex, BMI, lipid profiles, or insulin therapy method. However, a strong negative correlation was observed between long-term mean HbA1c and total TDI scores (r = -0.65, p < 0.001). Logistic regression confirmed that elevated mean HbA1c (> 7.0%) was a significant independent predictor of olfactory impairment, increasing the risk of hyposmia 3.7-fold (OR = 3.726, p = 0.018). CONCLUSIONS: Poor long-term glycemic control significantly impairs olfactory function in adolescents with Type 1 diabetes. This is demonstrated by the marked reduction in olfactory scores among adolescents with high mean HbA1c. Consequently, future research may validate olfactory testing as an effective, early biomarker for diabetic complications. CI - Copyright (c) 2026 Grzegorz Sobek et al. Journal of Diabetes Research published by John Wiley & Sons Ltd. FAU - Sobek, Grzegorz AU - Sobek G AUID- ORCID: 0000-0003-2504-0562 AD - Faculty of Health Sciences and Psychology, Collegium Medicum, University of Rzeszow, Rzeszow, Poland, ur.edu.pl. AD - University Center for Research and Development in Health Sciences, Rzeszow, Poland. FAU - Jagielski, Pawel AU - Jagielski P AUID- ORCID: 0000-0001-7583-8965 AD - Department of Nutrition and Drug Research, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland, cm-uj.krakow.pl. FAU - Mazur, Artur AU - Mazur A AUID- ORCID: 0000-0001-5393-3515 AD - Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland. LA - eng PT - Journal Article PL - United States TA - J Diabetes Res JT - Journal of diabetes research JID - 101605237 RN - 0 (Glycated Hemoglobin) RN - 0 (Blood Glucose) RN - 0 (hemoglobin A1c protein, human) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/blood/complications/physiopathology/drug therapy MH - Adolescent MH - Male MH - Female MH - *Glycemic Control MH - Glycated Hemoglobin/metabolism/analysis MH - Child MH - *Olfaction Disorders/etiology/physiopathology/diagnosis MH - *Blood Glucose/metabolism MH - *Smell/physiology MH - *Anosmia/etiology/physiopathology/diagnosis MH - Time Factors MH - Quality of Life PMC - PMC13575325 OTO - NOTNLM OT - Type 1 diabetes OT - adolescents OT - glycated hemoglobin OT - olfactory function COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 11:37 PMCR- 2026/09/14 CRDT- 2026/09/15 03:31 PHST- 2026/08/24 00:00 [revised] PHST- 2026/05/29 00:00 [received] PHST- 2026/08/29 00:00 [accepted] PHST- 2026/09/15 11:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:31 [entrez] PHST- 2026/09/14 00:00 [pmc-release] AID - JDR8415282 [pii] AID - 10.1155/jdr/8415282 [doi] PST - ppublish SO - J Diabetes Res. 2026;2026(1):e8415282. doi: 10.1155/jdr/8415282. PMID- 42739090 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Sep 6 TI - Maternal Consumption of Fruits, Vegetables and Fruit Juices in Relation to Offspring Weight at 4 Years. LID - 10.3390/nu18172918 [doi] LID - 2918 AB - Background/Objectives: Maternal diet plays a crucial role in fetal development and may influence offspring weight development. Although fruits and vegetables provide nutritional and metabolic benefits during pregnancy, evidence regarding their specific role on childhood overweight/obesity remains limited. This study aimed to examine the association between maternal intake of fruits, vegetables, and fruit juices during pregnancy and the risk of overweight/obesity in children at 4 years of age. Methods: We analyzed 252 mother-child pairs from the Mediterranean ECLIPSES cohort in a prospective observational study. Maternal dietary intake was assessed at 12, 24 and 36 weeks of gestation using a semiquantitative food frequency questionnaire previously validated in a Spanish population. Childhood overweight/obesity was defined as a BMI z-score above the 85th percentile for age and sex at age 4. Multivariable-adjusted logistic regression models estimated ORs and 95% CIs. Results: Higher maternal consumption of fruits and vegetables was inversely associated with overweight/obesity in children (OR: 0.31 [0.13-0.74]). No associations were observed for total or natural fruit juice, whereas higher consumption of commercial fruit juice was associated with increased odds of overweight/obesity (OR: 2.48 [1.06-5.78]). Conclusions: Higher maternal combined consumption of fruits and vegetables during pregnancy was associated with lower odds of overweight or obesity in offspring at 4 years of age, whereas the opposite association was observed for commercial, but not natural, fruit juice. These associations may involve both prenatal biological and postnatal behavioral and family dietary pathways; however, the commercial fruit juice finding should be considered exploratory and requires confirmation in larger prospective studies. FAU - Riggioni-Saborio, Lucia AU - Riggioni-Saborio L AUID- ORCID: 0009-0004-9880-7159 AD - Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Departament de Ciencies Mediques Basiques, Universitat Rovira i Virgili, 43201 Reus, Spain. FAU - Jardi, Cristina AU - Jardi C AUID- ORCID: 0000-0002-7946-1488 AD - Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Departament de Ciencies Mediques Basiques, Universitat Rovira i Virgili, 43201 Reus, Spain. AD - Institut de Recerca Biomedica Catalunya Sud (IRB CatSud), 43005 Tarragona, Spain. FAU - Becerra-Tomas, Nerea AU - Becerra-Tomas N AD - Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Departament de Ciencies Mediques Basiques, Universitat Rovira i Virgili, 43201 Reus, Spain. AD - Institut de Recerca Biomedica Catalunya Sud (IRB CatSud), 43005 Tarragona, Spain. FAU - Cruz-Rodriguez, Josue AU - Cruz-Rodriguez J AUID- ORCID: 0000-0001-7145-5836 AD - Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Departament de Ciencies Mediques Basiques, Universitat Rovira i Virgili, 43201 Reus, Spain. AD - Institut de Recerca Biomedica Catalunya Sud (IRB CatSud), 43005 Tarragona, Spain. FAU - Arija, Victoria AU - Arija V AUID- ORCID: 0000-0002-1758-0975 AD - Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Departament de Ciencies Mediques Basiques, Universitat Rovira i Virgili, 43201 Reus, Spain. AD - Institut de Recerca Biomedica Catalunya Sud (IRB CatSud), 43005 Tarragona, Spain. AD - Collaborative Group on Lifestyles, Nutrition, and Tobacco (CENIT), Institut D'Investigacio en Atencio Primaria IDIAP Jordi Gol, 08007 Barcelona, Spain. LA - eng GR - PI12/02777/Institute of Health Carlos III/ GR - PI17/01754/Instituto de Salud Carlos III/ GR - European Union/ PT - Journal Article PT - Observational Study DEP - 20260906 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Fruit MH - *Vegetables MH - Female MH - *Fruit and Vegetable Juices MH - Pregnancy MH - Child, Preschool MH - Prospective Studies MH - *Maternal Nutritional Physiological Phenomena MH - Spain/epidemiology MH - *Pediatric Obesity/epidemiology/prevention & control/etiology MH - Male MH - Adult MH - Developmental Origins of Health and Disease MH - *Diet PMC - PMC13567673 OTO - NOTNLM OT - childhood obesity OT - fruit consumption OT - fruit juice consumption OT - maternal nutrition OT - pregnancy OT - vegetable consumption COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 11:37 PMCR- 2026/09/06 CRDT- 2026/09/15 03:24 PHST- 2026/07/20 00:00 [received] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/04 00:00 [accepted] PHST- 2026/09/15 11:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:24 [entrez] PHST- 2026/09/06 00:00 [pmc-release] AID - nu18172918 [pii] AID - nutrients-18-02918 [pii] AID - 10.3390/nu18172918 [doi] PST - epublish SO - Nutrients. 2026 Sep 6;18(17):2918. doi: 10.3390/nu18172918. PMID- 42739088 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Sep 5 TI - Associations of Diabetes-Related Distress, Disordered-Eating Risk, and Self-Perceived Health with Glycemic Outcomes in Adolescents with Type 1 Diabetes: An Exploratory Cross-Sectional Study. LID - 10.3390/nu18172916 [doi] LID - 2916 AB - Background/Objectives: Adolescents with type 1 diabetes mellitus (T1DM) are particularly vulnerable to psychological distress, disordered-eating (DE) risk and negative self-perceived health status (SPHS), which may compromise metabolic control and self-care. Although these factors have been studied individually, the usefulness of brief and clinically feasible screening tools to detect these dimensions remains underexplored. This study aimed to: (1) examine associations between distress, DE risk and SPHS; (2) explore their relationships with glycemic control, clinical profile and self-care; and (3) assess the influence of age and diabetes duration on these outcomes. Methods: A cross-sectional study was conducted in 37 adolescents with T1DM in Spain. Sociodemographic, anthropometric and clinical variables were obtained from medical records. Distress, DE risk and self-care were assessed using validated questionnaires, while SPHS was measured using single-item question. Pearson and Spearman correlations were performed. Results: Distress was present in 48.6% of participants and DE risk in 29.7%, while 67.6% reported positive SPHS. Distress correlated with higher HbA1c and lower TIR. DE risk correlated with BMI. Lower SPHS was associated with higher HbA1c. Age and diabetes duration were associated with greater glycemic variability, and diabetes duration also correlated with higher glucose and TyG-based insulin resistance indexes. No significant associations were found for self-care behaviors. Conclusions: Distress, DE risk and SPHS, assessed through feasible screening tools, showed meaningful associations with metabolic outcomes in adolescents with T1DM. Integrating brief psychological screening tools into routine care may facilitate early identification of psychological vulnerability profiles in this population during routine practice. FAU - Garcia-Poblet, Marta AU - Garcia-Poblet M AUID- ORCID: 0000-0001-7110-6222 AD - Nursing Department, Faculty of Health Science, University of Alicante, 03692 Alicante, Spain. AD - Research Group on Applied Dietetics, Nutrition and Body Composition (DANuC), University of Alicante, 03692 Alicante, Spain. FAU - Sospedra, Isabel AU - Sospedra I AUID- ORCID: 0000-0002-8513-8986 AD - Nursing Department, Faculty of Health Science, University of Alicante, 03692 Alicante, Spain. AD - Research Group on Applied Dietetics, Nutrition and Body Composition (DANuC), University of Alicante, 03692 Alicante, Spain. FAU - Formilan, Brisa Florencia AU - Formilan BF AD - Nursing Department, Faculty of Health Science, University of Alicante, 03692 Alicante, Spain. FAU - Soler-Climent, Esther AU - Soler-Climent E AUID- ORCID: 0000-0002-8543-4865 AD - Research and Innovation Area, Health Department of General Hospital of Elche, 03203 Elche, Alicante, Spain. AD - Traumatology and Neurosurgery Service, General Hospital of Elche, 03203 Elche, Alicante, Spain. FAU - Alberola-Chazarra, Manuel Antonio AU - Alberola-Chazarra MA AD - Pediatrics Unit, General Hospital of Elche, 03203 Elche, Alicante, Spain. FAU - Martinez-Sanz, Jose Miguel AU - Martinez-Sanz JM AUID- ORCID: 0000-0001-9054-3858 AD - Nursing Department, Faculty of Health Science, University of Alicante, 03692 Alicante, Spain. AD - Research Group on Applied Dietetics, Nutrition and Body Composition (DANuC), University of Alicante, 03692 Alicante, Spain. LA - eng PT - Journal Article DEP - 20260905 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Blood Glucose) RN - 0 (Glycated Hemoglobin) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/psychology/blood/complications MH - Adolescent MH - Cross-Sectional Studies MH - Female MH - Male MH - *Feeding and Eating Disorders/psychology/epidemiology MH - *Psychological Distress MH - *Self Concept MH - Self Care MH - Blood Glucose/metabolism MH - *Stress, Psychological MH - Risk Factors MH - Glycated Hemoglobin MH - Glycemic Control/psychology MH - Health Status MH - Spain MH - Surveys and Questionnaires PMC - PMC13567549 OTO - NOTNLM OT - adolescents OT - eating disorders OT - metabolic control OT - psychological distress OT - self-perceived health OT - type 1 diabetes mellitus COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 11:37 PMCR- 2026/09/05 CRDT- 2026/09/15 03:24 PHST- 2026/07/04 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/08/28 00:00 [accepted] PHST- 2026/09/15 11:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:24 [entrez] PHST- 2026/09/05 00:00 [pmc-release] AID - nu18172916 [pii] AID - nutrients-18-02916 [pii] AID - 10.3390/nu18172916 [doi] PST - epublish SO - Nutrients. 2026 Sep 5;18(17):2916. doi: 10.3390/nu18172916. PMID- 42739059 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Sep 3 TI - Assessment of Nutritional Risk Representations in Publicly Available Data in Saudi Arabia: A Triangulated Scoping Study. LID - 10.3390/nu18172888 [doi] LID - 2888 AB - Background: Saudi Arabia maintains official statistics on its food security, in addition to conducting surveys on health parameters and performing national health assessments. Also, several academic papers on dietary patterns are published every year. Many published documents analyze data on food availability, self-reported eating habits, and biomarker-based health risks. However, individually, they represent distinct aspects of nutrition. Hence, this study was undertaken to examine publicly accessible nutrition-related evidence in Saudi Arabia and assess whether existing public food and nutrition datasets consistently align with the biological indicators of nutritional risk. Methods: Searches were conducted using defined criteria in publicly available Saudi and international sources published or updated between 2005 and 2025. These were identified through official reports, global food databases, WHO-aligned surveys, and peer-reviewed articles, with searches conducted and updated during June-July 2026. Sources were classified by representativeness, recency, measurement validity, accessibility, and analytical role. The primary outcome was the completeness and interpretability of public evidence streams rather than a pooled prevalence estimate. Results: SHIS 2013 remains the top public national dietary intake dataset, which shows that only 5.2% and 7.5% of people met their fruit and vegetable intake recommendations, respectively. GASTAT Health Determinants Statistics 2024 indicated that only 10.2% of people aged 15 years and above ate five or more portions of fruits and vegetables daily, yet GASTAT Food Security Statistics 2024 indicated significant per capita availability of rice, milk, poultry, eggs, red meat, onions, tomatoes, and dates. High levels of biological risk were evident in WHS 2019 biomarkers; for example, 42.6% of people had hypercholesterolemia and 50% had low hemoglobin according to the WHS 2019 indicator definition. Recent studies provided additional data on beverages, sugars, dietary habits of adolescents, and diet quality but lacked national food-wide intake data. Conclusions: Public Saudi nutrition data provide complementary but non-equivalent information; indicators show low dietary adequacy and high biomarker-defined risk, supporting the need for integrated individual-level nutrition surveillance. In the future, Saudi national nutrition surveillance must focus on individual-level intake data and biomarker-based measurements. FAU - Alagal, Reham I AU - Alagal RI AUID- ORCID: 0000-0002-8515-1574 AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260903 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) SB - IM MH - Saudi Arabia/epidemiology MH - Humans MH - *Diet/statistics & numerical data MH - *Nutritional Status MH - Vegetables MH - Fruit MH - Feeding Behavior MH - Risk Assessment MH - Adolescent MH - Biomarkers MH - Female PMC - PMC13567205 OTO - NOTNLM OT - Saudi Arabia OT - biomarkers OT - dietary consumption OT - food availability OT - food balance sheets OT - fruit and vegetable consumption OT - hypercholesterolaemia OT - low haemoglobin OT - nutrition surveillance COIS- The author declares no conflict of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/09/03 CRDT- 2026/09/15 03:24 PHST- 2026/07/05 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:24 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - nu18172888 [pii] AID - nutrients-18-02888 [pii] AID - 10.3390/nu18172888 [doi] PST - epublish SO - Nutrients. 2026 Sep 3;18(17):2888. doi: 10.3390/nu18172888. PMID- 42739031 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Sep 1 TI - A Comprehensive Study of Dietary and Lifestyle Correlates of Erythrocyte Membrane Fatty Acids and Oxidative Stress and Their Association with Maternal and Neonatal Outcomes. LID - 10.3390/nu18172859 [doi] LID - 2859 AB - Background: Erythrocyte fatty acid (FA) and oxidative stress levels are influenced by a range of factors. The aim of this study was to evaluate erythrocyte FA profiles and oxidative stress markers and their relationships with each other, nutrition, lifestyle, gestational age, and pregnancy outcomes in pregnant Latvian women. Methods: A total of 74 pregnant and postpartum women were cross-sectionally examined. Dietary intake was assessed using a validated food frequency questionnaire; erythrocyte FA composition was analyzed using gas chromatography with a flame ionization detector; and oxidative status was assessed based on Ferric Reducing Antioxidant Power (FRAP) assays, glutathione peroxidase (GPx) activity, and selenoprotein P (SEPP1) and malondialdehyde (MDA) levels. Results: Dietary fats constituted 42.0% of the total caloric intake. Saturated fatty acids (SFAs) predominated in erythrocytes (55.7%), with the highest concentration observed for 16:0. Although multiple significant correlations between dietary factors and laboratory parameters were identified, none remained significant after correction for multiple comparisons. Erythrocyte 18:3, n-3 was significantly associated with FRAP (p < 0.05). Gestational complications and age did not affect biochemical parameters (p > 0.05), though gestational age correlated with MDA (r = 0.377, p < 0.05) and pre-pregnancy body mass index (BMI) with MUFAs (r = 0.373, p < 0.01). The FA composition differed depending on smoking status and alcohol consumption. Conclusions: Given the exploratory nature of this study, findings should be interpreted with appropriate caution. Several associations retained statistical significance following correction for multiple comparisons, namely between erythrocyte 18:3, n-3 and FRAP, alcohol consumption and smoking with erythrocyte fatty acid profiles, maternal age and plasma MDA concentrations, and pre-gestational BMI and MUFA levels. The remaining associations did not withstand correction and should therefore be regarded as hypothesis-generating, warranting confirmation in larger, adequately powered, confirmatory studies. FAU - Nikolajeva, Ksenija AU - Nikolajeva K AD - Riga East Clinical University Hospital, 2 Hipokrata Street, LV-1038 Riga, Latvia. AD - Doctoral Department, Faculty of Medicine, Riga Stradins University, 16 Dzirciema Street, LV-1007 Riga, Latvia. AD - Department of Rehabilitation, Riga Stradins University, 26a Anninmuizas Boulevard, LV-1067 Riga, Latvia. FAU - Lece, Anna AU - Lece A AUID- ORCID: 0000-0002-0970-2127 AD - Institute of Occupational Safety and Environmental Health, Riga Stradins University, LV-1067 Riga, Latvia. FAU - Skesters, Andrejs AU - Skesters A AUID- ORCID: 0000-0003-3726-8724 AD - Institute of Occupational Safety and Environmental Health, Riga Stradins University, LV-1067 Riga, Latvia. FAU - Cauce, Vinita AU - Cauce V AD - Statistics Unit, Riga Stradins University, 14 Balozu Street, LV-1048 Riga, Latvia. FAU - Zacs, Dzintars AU - Zacs D AD - Scientific Institute of Food Safety, Animal Health, and Environment, Lejupes Street 3, LV-1076 Riga, Latvia. FAU - Meija, Laila AU - Meija L AUID- ORCID: 0000-0002-8205-0639 AD - Riga East Clinical University Hospital, 2 Hipokrata Street, LV-1038 Riga, Latvia. AD - Department of Rehabilitation, Riga Stradins University, 26a Anninmuizas Boulevard, LV-1067 Riga, Latvia. LA - eng GR - Izp-2019/1-0335/Latvian Council of Science/ GR - 6-DN-20/4/2026/Riga Stradins University/ PT - Journal Article DEP - 20260901 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Fatty Acids) RN - 0 (Biomarkers) RN - 0 (Dietary Fats) SB - IM MH - Humans MH - Female MH - *Oxidative Stress MH - Pregnancy MH - *Fatty Acids/blood MH - Adult MH - *Life Style MH - *Erythrocyte Membrane/metabolism/chemistry MH - Cross-Sectional Studies MH - *Pregnancy Outcome MH - *Diet MH - Biomarkers/blood MH - Gestational Age MH - Infant, Newborn MH - Latvia MH - Nutritional Status MH - Dietary Fats PMC - PMC13567114 OTO - NOTNLM OT - fatty acids OT - nutrition OT - oxidative stress OT - pregnancy COIS- The authors declare no conflict of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 11:38 PMCR- 2026/09/01 CRDT- 2026/09/15 03:23 PHST- 2026/05/25 00:00 [received] PHST- 2026/08/04 00:00 [revised] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/09/15 11:38 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - nu18172859 [pii] AID - nutrients-18-02859 [pii] AID - 10.3390/nu18172859 [doi] PST - epublish SO - Nutrients. 2026 Sep 1;18(17):2859. doi: 10.3390/nu18172859. PMID- 42738991 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 28 TI - Dairy Product Consumption Patterns and Associated Sociodemographic and Lifestyle Factors Among Adults from Selected Peruvian Cities. LID - 10.3390/nu18172819 [doi] LID - 2819 AB - Background: Dairy products provide protein, calcium, and other essential nutrients, but intake may vary across sociodemographic and lifestyle groups. Objective: To characterize dairy consumption patterns and identify factors associated with consuming >/=3 dairy servings/day among adults recruited from selected Peruvian cities. Methods: A cross-sectional study was conducted from April to June 2026. Of the 1619 eligible participants, 203 (12.5%) reported no dairy consumption and were analyzed separately for reasons for non-consumption; the final analytical sample included 1265 dairy consumers. Dairy intake was assessed using a culturally adapted questionnaire with content validity evaluated by expert judgment. Descriptive analyses, bivariate tests, and multivariable logistic regression were performed. Results: Mean age was 33.0 +/- 13.0 years, and 61.2% were women. The most commonly consumed products were cheese (90.9%), yogurt (85.4%), whole milk (71.2%), and quesillo or fresh cheese (60.8%). Overall, 16.3% consumed >/=3 dairy servings/day. Participants recruited from cities in the Highlands (aOR = 0.54; 95% CI: 0.37-0.79) and Amazon (aOR = 0.59; 95% CI: 0.40-0.87) had lower odds of reaching this threshold than those from the Coast. Middle socioeconomic status was associated with lower odds (aOR = 0.48; 95% CI: 0.34-0.67), whereas physical activity >/=3 times/week was associated with higher odds (aOR = 1.53; 95% CI: 1.09-2.14). Perceived lactose intolerance was the most frequently reported reason for non-consumption (46.8%). Conclusions: Consumption of >/=3 dairy servings/day was uncommon. Socioeconomic differences were the most consistent correlate, while geographic and physical activity associations warrant cautious interpretation. FAU - Paz-Olivas, Youmi AU - Paz-Olivas Y AD - Area de Investigacion, Instituto de Nutricion y Seguridad Alimentaria, Lima 15026, Peru. AD - Escuela de Nutricion y Dietetica, Universidad Femenina Sagrado Corazon (UNIFE), La Molina, Lima 15023, Peru. FAU - Duran-Aguero, Samuel AU - Duran-Aguero S AUID- ORCID: 0000-0002-0548-3676 AD - Facultad de Ciencias de la Rehabilitacion y Calidad de Vida, Universidad San Sebastian, Providencia 7500000, Chile. FAU - Saintila, Jacksaint AU - Saintila J AUID- ORCID: 0000-0002-7340-7974 AD - Research Group on Nutritional Psychology and Public Health, Universidad Peruana Union, Lima 15464, Peru. LA - eng PT - Journal Article DEP - 20260828 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Adult MH - Peru MH - *Dairy Products/statistics & numerical data MH - Cross-Sectional Studies MH - Male MH - *Life Style MH - Middle Aged MH - *Sociodemographic Factors MH - Young Adult MH - Socioeconomic Factors MH - Cities MH - *Diet/statistics & numerical data MH - *Feeding Behavior MH - Adolescent PMC - PMC13567231 OTO - NOTNLM OT - Peru OT - adults OT - dairy products OT - dietary intake OT - food consumption OT - lactose intolerance OT - socioeconomic status COIS- Y.P.-O. is employed as Nutrition Manager at Grupo Gloria, a company operating in the dairy sector. Grupo Gloria had no role in the funding of the study; study design; data collection, analysis, or interpretation; preparation or writing of the manuscript; or the decision to submit the manuscript for publication. S.D.-A. and J.S. declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/28 CRDT- 2026/09/15 03:23 PHST- 2026/08/03 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/28 00:00 [pmc-release] AID - nu18172819 [pii] AID - nutrients-18-02819 [pii] AID - 10.3390/nu18172819 [doi] PST - epublish SO - Nutrients. 2026 Aug 28;18(17):2819. doi: 10.3390/nu18172819. PMID- 42738982 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 27 TI - Mediterranean Diet Adherence, Nutrition Knowledge and Lifestyle Factors in Physically Active Adults and Athletes: The NUTRI_ACTIVE Study. LID - 10.3390/nu18172810 [doi] LID - 2810 AB - Background/Objectives: Unhealthy diets and poor lifestyle choices can increase athlete's risk of low energy availability (LEA) and its negative consequences. Conversely, optimal nutrition, such as the Mediterranean Diet (MedDiet), promotes health, recovery, and performance. This study evaluates MedDiet adherence among athletes and physically active individuals, exploring its relationship with nutrition knowledge (NK), dietary intake, eating behaviors, and sleep quality. Methods: This single-center observational study evaluated Italian healthy active adults/athletes (18-65 years) categorized into four performance Tiers. Validated questionnaires analyzed MedDiet adherence (MEDI-LITE), NK (GeSNK), eating behaviour (EAT-26 and TOS), sleep quality (PSQI), and physical activity (IPAQ). Dietary intake was estimated via a 7-day food diary. Body composition (skinfolds/BIVA), and resting energy expenditure (indirect calorimetry) were assessed. Results: Analysis included 169 participants (32.3 +/- 11.9 years; 52.7% females; 56.8% Tier 1), practicing 2.0 +/- 0.9 sports with 7.1 +/- 3.7 h/week of training. Mean MEDI-LITE score was 10.6 +/- 2.2 (moderate adherence) across all Tiers and was significantly, positively associated with NK (p = 0.002). Mean EA was 31.3 +/- 8.6 kcal/kg FFM/day; sex-specific cut-offs revealed a substantial proportion of high-tier participants with low/suboptimal EA. Eating disorder risk and orthorexic tendencies were low, sleep quality was generally good; none significantly correlated with MEDI-LITE score. Conclusions: Higher NK was positively associated with MedDiet adherence. However, high-tier athletes showed low or suboptimal EA. Targeted nutrition education must integrate MedDiet principles with sport-specific fueling strategies, optimizing diet quality and energy adequacy. FAU - Fiorini, Simona AU - Fiorini S AUID- ORCID: 0009-0005-2790-0601 AD - Laboratory of Food Education and Sport Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Guglielmetti, Monica AU - Guglielmetti M AUID- ORCID: 0000-0001-6327-9959 AD - Laboratory of Food Education and Sport Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Lopes Neri, Lenycia de Cassya AU - Lopes Neri LC AUID- ORCID: 0000-0002-4162-3664 AD - Laboratory of Food Education and Sport Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Ferraro, Ottavia Eleonora AU - Ferraro OE AUID- ORCID: 0000-0002-4398-4885 AD - Unit of Biostatistics and Clinical Epidemiology, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Rondanelli, Mariangela AU - Rondanelli M AUID- ORCID: 0000-0001-8336-4851 AD - Human Nutrition and Eating Disorder Research Center, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Tagliabue, Anna AU - Tagliabue A AUID- ORCID: 0000-0002-7647-6975 AD - Human Nutrition and Eating Disorder Research Center, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Ferraris, Cinzia AU - Ferraris C AUID- ORCID: 0000-0002-4148-2136 AD - Laboratory of Food Education and Sport Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. LA - eng GR - Project code PE0000003/Ministry of Universities and Research/ PT - Journal Article PT - Observational Study DEP - 20260827 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Diet, Mediterranean MH - Female MH - Male MH - Adult MH - *Athletes/psychology/statistics & numerical data MH - Young Adult MH - Middle Aged MH - *Life Style MH - *Health Knowledge, Attitudes, Practice MH - Adolescent MH - Feeding Behavior MH - *Exercise MH - Aged MH - Italy MH - Surveys and Questionnaires MH - *Patient Compliance MH - Energy Metabolism MH - Energy Intake MH - Body Composition MH - Sleep Quality MH - Nutritional Status PMC - PMC13567227 OTO - NOTNLM OT - athletes OT - energy availability OT - lifestyle OT - mediterranean diet OT - nutrition knowledge OT - sport nutrition COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/27 CRDT- 2026/09/15 03:23 PHST- 2026/07/21 00:00 [received] PHST- 2026/08/22 00:00 [revised] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - nu18172810 [pii] AID - nutrients-18-02810 [pii] AID - 10.3390/nu18172810 [doi] PST - epublish SO - Nutrients. 2026 Aug 27;18(17):2810. doi: 10.3390/nu18172810. PMID- 42738966 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 26 TI - Associations and Multidimensional Characterization of the Nutritional-Inflammatory Profile in Children with Previous SARS-CoV-2 Infection: A Retrospective Cohort Study. LID - 10.3390/nu18172793 [doi] LID - 2793 AB - Background/Objectives: Nutritional, inflammatory, and lifestyle-related characteristics may contribute to substantial biological heterogeneity among children with documented previous SARS-CoV-2 infection. This study aimed to characterize an integrated nutritional-inflammatory profile and explore its relationships with biological and clinical features in a hospitalized pediatric cohort. Methods: This retrospective cohort study included 260 children with documented previous SARS-CoV-2 infection. Clinical, anthropometric, and laboratory data were complemented by questionnaire-derived dietary and lifestyle information (n = 213). Analyses combined conventional statistics with correlation and multivariate techniques, including PCA and K-means clustering (n = 231) and exploratory Ridge regression (n = 188). Results: Suboptimal serum 25(OH)D concentrations (<30 ng/mL) were present in 55.8% of participants (95% CI [49.7%, 61.7%]), while 43.5% were overweight or obese (95% CI [37.6%, 49.5%]). BMI correlated with hemoglobin (rho = 0.23) and CRP (rho = 0.12), while 25(OH)D correlated with potassium (rho = 0.22). Increasing daily device use was associated with progressively lower 25(OH)D concentrations (H = 24, p < 0.001, epsilon(2) = 0.11), with median values decreasing from 33 ng/mL at <1 h/day to 24 ng/mL at >4 h/day. PCA identified three complementary biological dimensions explaining 55.0% of the total variance, while K-means clustering identified three reproducible exploratory nutritional-inflammatory phenotypes differentiated by age, BMI, hematological and inflammatory characteristics, and selected lifestyle factors. Conclusions: The findings show multidimensional nutritional-inflammatory heterogeneity in children with documented previous SARS-CoV-2 infection. The identified patterns and exploratory phenotypes provide an integrated framework for biological characterization and warrant validation in prospective multicenter cohorts. FAU - Petrea Cliveti, Carmen Loredana AU - Petrea Cliveti CL AUID- ORCID: 0009-0001-8838-8817 AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. AD - "Sf. Ioan" Emergency Clinical Hospital for Children, 800487 Galati, Romania. FAU - Ciortea, Diana-Andreea AU - Ciortea DA AUID- ORCID: 0000-0001-7420-256X AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. AD - "Maria Sklodowska Curie" Emergency Clinical Hospital for Children, 041451 Bucharest, Romania. FAU - Gurau, Gabriela AU - Gurau G AUID- ORCID: 0000-0001-8327-1364 AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. AD - "Sf. Ioan" Emergency Clinical Hospital for Children, 800487 Galati, Romania. FAU - Matei, Madalina Nicoleta AU - Matei MN AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. AD - "Sf. Ioan" Emergency Clinical Hospital for Children, 800487 Galati, Romania. FAU - Barbu, Codrina AU - Barbu C AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. AD - "Sf. Ioan" Emergency Clinical Hospital for Children, 800487 Galati, Romania. FAU - Verga Rauta, Gabriela Isabela AU - Verga Rauta GI AUID- ORCID: 0009-0009-5438-666X AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. AD - "Sf. Ioan" Emergency Clinical Hospital for Children, 800487 Galati, Romania. FAU - Lungu, Irinel AU - Lungu I AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. AD - "Sf. Ioan" Emergency Clinical Hospital for Children, 800487 Galati, Romania. FAU - Valcan, Mariana Mirela AU - Valcan MM AUID- ORCID: 0000-0001-5347-4267 AD - Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania. FAU - Berbece, Sorin Ion AU - Berbece SI AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. LA - eng PT - Journal Article DEP - 20260826 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) SB - IM MH - Humans MH - *COVID-19 MH - Retrospective Studies MH - Female MH - SARS-CoV-2 MH - Child MH - Male MH - *Nutritional Status MH - Vitamin D/blood/analogs & derivatives MH - *Inflammation/blood MH - Adolescent MH - Life Style MH - Body Mass Index MH - Child, Preschool PMC - PMC13567281 OTO - NOTNLM OT - 25-hydroxyvitamin D OT - children OT - exploratory phenotypes OT - inflammatory biomarkers OT - lifestyle OT - nutritional-inflammatory profile OT - previous SARS-CoV-2 infection OT - principal component analysis COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 11:37 PMCR- 2026/08/26 CRDT- 2026/09/15 03:23 PHST- 2026/07/13 00:00 [received] PHST- 2026/08/20 00:00 [revised] PHST- 2026/08/22 00:00 [accepted] PHST- 2026/09/15 11:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/26 00:00 [pmc-release] AID - nu18172793 [pii] AID - nutrients-18-02793 [pii] AID - 10.3390/nu18172793 [doi] PST - epublish SO - Nutrients. 2026 Aug 26;18(17):2793. doi: 10.3390/nu18172793. PMID- 42738956 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 26 TI - Beverage Consumption Patterns, Beverage-Derived Energy Intake, and Adherence to Fluid Intake Recommendations Among Polish Adolescents: A Cross-Sectional Study Using the BEVQ-PL Questionnaire. LID - 10.3390/nu18172784 [doi] LID - 2784 AB - Background/Objectives: Different organizations have established fluid intake recommendations for adolescents; however, studies assessing adherence typically rely on a single reference system, limiting comparisons across populations. This study assessed beverage consumption patterns and beverage-derived energy intake among Polish adolescents and examined how adherence estimates differed when recommendations issued by the European Food Safety Authority (EFSA), the Institute of Medicine (IOM), and the Polish National Institute of Public Health-National Institute of Hygiene (NIH) were applied. Methods: A cross-sectional study was conducted among 1644 secondary school students aged 14-18 years. Beverage consumption (mL/day) and beverage-derived energy intake (kcal/day) were assessed using the validated Polish Beverage Intake Questionnaire (BEVQ-PL). Adherence was defined as achieving at least 80% of the age- and sex-specific Adequate Intake (AI) from beverages, assuming that beverages provide approximately 80% of total daily water intake. Results: Water had the highest median daily intake (960 mL/day). Males consumed significantly more water than females (1080 vs. 720 mL/day; p = 0.037), whereas females consumed significantly more reduced-fat milk (2%), skim milk, plant-based and flavored milk beverages, 100% vegetable juice, and coffee with milk and sugar. Adherence differed according to the recommendation system, reaching 65.2% (EFSA), 50.6% (IOM), and 65.8% (NIH). Female sex was independently associated with higher adherence across all three reference systems, whereas older age was associated with lower adherence only according to the NIH criteria and overweight/obesity only according to the IOM criteria. Conclusions: Estimated adherence to fluid intake recommendations varied substantially according to the reference system applied. These findings highlight the importance of explicitly reporting the selected reference criteria when assessing and comparing the adequacy of beverage-derived fluid intake among adolescents. FAU - Zborowski, Marek AU - Zborowski M AUID- ORCID: 0000-0003-2695-2491 AD - The Faculty of Medicine and Health Sciences, University of Applied Sciences in Nowy Sacz, Kosciuszki 2G, 33-300 Nowy Sacz, Poland. FAU - Skotnicka, Magdalena AU - Skotnicka M AUID- ORCID: 0000-0002-0853-0685 AD - Department of Commodity Science, Faculty of Health Sciences, Medical University of Gdansk, 7 Debinki Street, 80-210 Gdansk, Poland. LA - eng PT - Journal Article DEP - 20260826 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - Cross-Sectional Studies MH - Female MH - Male MH - *Beverages MH - Poland MH - *Energy Intake MH - *Drinking MH - Surveys and Questionnaires MH - Recommended Dietary Allowances MH - Animals MH - Guideline Adherence MH - *Patient Compliance PMC - PMC13567327 OTO - NOTNLM OT - BEVQ-PL OT - adequate intake OT - adolescents OT - beverage consumption OT - hydration recommendations COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/26 CRDT- 2026/09/15 03:23 PHST- 2026/08/01 00:00 [received] PHST- 2026/08/22 00:00 [revised] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/26 00:00 [pmc-release] AID - nu18172784 [pii] AID - nutrients-18-02784 [pii] AID - 10.3390/nu18172784 [doi] PST - epublish SO - Nutrients. 2026 Aug 26;18(17):2784. doi: 10.3390/nu18172784. PMID- 42738947 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260922 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 25 TI - Association of Sleep Duration and Physical Activity with Healthy Eating Habits Among Peruvian Secondary School Students. LID - 10.3390/nu18172775 [doi] LID - 2775 AB - Background/Objectives: Sleep duration and physical activity are key behavioral components in the development of healthy lifestyles during adolescence. In Peru, a considerable proportion of school students do not meet recommended levels of physical activity and may also experience insufficient sleep, which could negatively affect their eating habits. This study aimed to analyze the association between sleep duration, physical activity level, and healthy eating habits among Peruvian secondary school students. Methods: An observational, analytical, cross-sectional study was conducted among 275 secondary school students aged 12 to 17 years. Sleep duration, physical activity, and eating habits were assessed using validated questionnaires. Associations were analyzed using Pearson's chi-square test and multivariable binary logistic regression. Results: Students who slept 7 h had higher odds of having healthy eating habits compared with those who slept 6 h or less (aOR = 2.525; 95% CI: 1.181-5.536; p = 0.018). In addition, students with low levels of physical activity showed lower odds of having healthy eating habits compared with those with high levels of physical activity (aOR = 0.097; 95% CI: 0.005-0.564; p = 0.032). Conclusions: Sleep duration and physical activity were associated with healthy eating habits among Peruvian secondary school students. These findings support the importance of promoting integrated school-based strategies that jointly address sleep, physical activity, and nutrition during adolescence. FAU - Remon-Lopez, Jennyfer A AU - Remon-Lopez JA AD - Escuela de Nutricion Humana, Facultad de Ciencias de la Salud, Universidad Peruana Union, Lima 15102, Peru. FAU - Chilon-Llico, Raquel AU - Chilon-Llico R AD - Escuela de Nutricion Humana, Facultad de Ciencias de la Salud, Universidad Peruana Union, Lima 15102, Peru. FAU - Peralta-Eugenio, Gutember AU - Peralta-Eugenio G AUID- ORCID: 0000-0002-1177-6088 AD - Facultad de Ciencias de la Salud, Escuela de Psicologia, Universidad Cesar Vallejo, Chimbote 02801, Peru. FAU - Morales-Garcia, Wilter C AU - Morales-Garcia WC AUID- ORCID: 0000-0003-1208-9121 AD - Facultad de Teologia, Universidad Peruana Union, Lima 15102, Peru. FAU - Sairitupa-Sanchez, Liset Z AU - Sairitupa-Sanchez LZ AUID- ORCID: 0000-0003-0555-091X AD - Escuela de Psicologia, Universidad Senor de Sipan, Chiclayo 14001, Peru. FAU - Morales-Garcia, Sandra B AU - Morales-Garcia SB AUID- ORCID: 0000-0002-5102-303X AD - Escuela de Medicina Humana, Universidad Senor de Sipan, Chiclayo 14001, Peru. FAU - Rivera-Lozada, Oriana AU - Rivera-Lozada O AD - Escuela de Medicina Humana, Universidad Senor de Sipan, Chiclayo 14001, Peru. FAU - Morales-Garcia, Mardel AU - Morales-Garcia M AUID- ORCID: 0000-0002-6413-1072 AD - Direccion de Investigacion, Escuela de Posgrado, Universidad Peruana Union, Lima 15102, Peru. LA - eng PT - Journal Article PT - Observational Study DEP - 20260825 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - *Sleep Duration MH - Peru MH - Female MH - Male MH - Cross-Sectional Studies MH - Child MH - *Exercise MH - *Feeding Behavior MH - *Students/statistics & numerical data MH - *Diet, Healthy MH - Schools MH - Surveys and Questionnaires MH - Logistic Models MH - *Sleep MH - Adolescent Behavior PMC - PMC13567383 OTO - NOTNLM OT - Peru OT - adolescents OT - healthy eating habits OT - physical activity OT - sleep duration COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/25 CRDT- 2026/09/15 03:23 PHST- 2026/04/14 00:00 [received] PHST- 2026/05/01 00:00 [revised] PHST- 2026/05/06 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - nu18172775 [pii] AID - nutrients-18-02775 [pii] AID - 10.3390/nu18172775 [doi] PST - epublish SO - Nutrients. 2026 Aug 25;18(17):2775. doi: 10.3390/nu18172775. PMID- 42737710 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 27 IP - 17 DP - 2026 Aug 31 TI - Enzyme-Specific Redox Stability and Plasticity in Trained Youth Athletes: Longitudinal Analysis of SOD and GPX. LID - 10.3390/ijms27177813 [doi] LID - 7813 AB - Resting antioxidant enzyme activity in youth athletes may reflect stable individual redox characteristics and developmentally modulated plasticity. This 12-month longitudinal analysis from the MuCAYA(plus) study examined the tracking of superoxide dismutase (SOD) and glutathione peroxidase (GPX) in 69 trained athletes aged 10-17 years. Participants underwent repeated assessments of antioxidant enzyme activity, training exposure, body composition, and hematological parameters. Longitudinal tracking was evaluated using Pearson correlation and intraclass correlation coefficients, while change-score regression models tested whether changes in training exposure, growth-related variables, sex interactions, and hematological parameters predicted changes in SOD or GPX. In exploratory analyses, cluster-based redox phenotype stability was assessed using agreement statistics. Over 12 months, SOD decreased whereas GPX increased. GPX showed substantial tracking (r = 0.714, p < 0.001; ICC = 0.683), while SOD showed no meaningful tracking (r = 0.057, p = 0.644; ICC = 0.053). No statistically supported associations were detected between changes in training-exposure or growth-related measures and enzyme changes. Exploratory erythrocyte-related associations were observed for SOD, whereas leukocyte and platelet changes were unrelated. Cluster-based SOD/GPX phenotype analyses were not robust. These findings are compatible with a comparatively stronger trait-like component for GPX and greater state-like variability for SOD. FAU - Haferanke, Jonas AU - Haferanke J AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Dettenhofer, Maximilian AU - Dettenhofer M AUID- ORCID: 0009-0003-1733-6360 AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Huber, Stefanie AU - Huber S AUID- ORCID: 0009-0002-0757-7681 AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Muhlbauer, Frauke AU - Muhlbauer F AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Baumgartner, Lisa AU - Baumgartner L AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Engl, Tobias AU - Engl T AUID- ORCID: 0000-0002-6251-9532 AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Schulz, Thorsten AU - Schulz T AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Oberhoffer, Renate AU - Oberhoffer R AUID- ORCID: 0000-0002-3166-0488 AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Freilinger, Sebastian AU - Freilinger S AUID- ORCID: 0009-0000-3755-6481 AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. LA - eng GR - 516547656/Deutsche Forschungsgemeinschaft/ PT - Journal Article DEP - 20260831 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - EC 1.15.1.1 (Superoxide Dismutase) RN - EC 1.11.1.9 (Glutathione Peroxidase) RN - 0 (Antioxidants) SB - IM MH - Humans MH - *Superoxide Dismutase/metabolism MH - *Glutathione Peroxidase/metabolism MH - *Athletes MH - Oxidation-Reduction MH - Adolescent MH - Male MH - Longitudinal Studies MH - Female MH - Child MH - Antioxidants/metabolism MH - Body Composition PMC - PMC13566580 OTO - NOTNLM OT - antioxidative capacity OT - glutathione peroxidase OT - oxidative stress OT - pediatric exercise science OT - physical activity OT - redox plasticity OT - superoxide dismutase OT - training adaptation OT - young athletes COIS- The authors declare no conflict of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/31 CRDT- 2026/09/15 03:21 PHST- 2026/07/27 00:00 [received] PHST- 2026/08/28 00:00 [revised] PHST- 2026/08/28 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:21 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - ijms27177813 [pii] AID - ijms-27-07813 [pii] AID - 10.3390/ijms27177813 [doi] PST - epublish SO - Int J Mol Sci. 2026 Aug 31;27(17):7813. doi: 10.3390/ijms27177813. PMID- 42736733 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20261010 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 37 DP - 2026 Sep 11 TI - A machine learning model integrating radiomics and clinical factors to predict recurrence risk after rehabilitation in lumbar disc herniation. PG - e50454 LID - 10.1097/MD.0000000000050454 [doi] LID - e50454 AB - This study aimed to construct and internally validate a machine learning model integrating radiomics features and clinical factors to predict post-rehabilitation recurrence risk in patients with lumbar disc herniation (LDH). In this single-center retrospective cohort study, 260 adults aged 18 to 70 years with LDH who completed standardized rehabilitation were analyzed (78 with recurrence and 182 without recurrence). Radiomics features were extracted separately from sagittal T1-weighted, sagittal T2-weighted, and axial T2-weighted magnetic resonance imaging, standardized, concatenated across sequences, and reduced using least absolute shrinkage and selection operator regression. Three logistic regression models were developed: radiomics-only, clinical plus rehabilitation, and combined models. A stratified 70/30 split provided internal validation; receiver operating characteristic curves, calibration analysis, decision curve analysis, and risk stratification were used to evaluate performance. A separate multivariable logistic regression analysis was used to identify clinically interpretable predictors. Age, body mass index, disc height index, improvement in the Oswestry Disability Index, diabetes, Modic changes, and poor rehabilitation adherence differed significantly between the recurrence and non-recurrence groups (all P < .05). The combined model demonstrated the best predictive performance, with an area under the curve (AUC) of 0.85 (95% confidence interval: 0.78-0.91), outperforming the radiomics model (AUC = 0.78) and the clinical model (AUC = 0.76). The calibration curve showed strong agreement between predicted and observed recurrence, and decision curve analysis indicated superior net clinical benefit across a wide range of thresholds. Based on predicted probabilities, patients were stratified into low- (<20%), intermediate- (20%-40%), and high-risk (>40%) groups, with recurrence rates of 15.0%, 30.0%, and 66.0%, respectively (P < .001). Multivariable logistic regression identified disc height index (odds ratio [OR] = 1.80), Oswestry Disability Index improvement (OR = 0.65), poor rehabilitation adherence (OR = 2.50), diabetes (OR = 2.10), and Modic changes (OR = 1.90) as independent predictors of recurrence. Integrating multisequence weighted magnetic resonance imaging radiomics with clinical and rehabilitation variables improved internal prediction of post-rehabilitation recurrence in LDH. The combined model may support risk-adapted rehabilitation intensity and follow-up, but it requires prospective, multicenter external validation before routine clinical use. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Qi, Yanhong AU - Qi Y AD - Medical Department, Beidaihe Rest and Recuperation Center of the Joint Logistics Support Force, PLA, Beidaihe City, Hebei Province, China. FAU - Feng, Yifei AU - Feng Y AD - Department of Medical Imaging, Beidaihe Rest and Recuperation Center of the Joint Logistics Support Force, PLA, Beidaihe City, Hebei Province, China. FAU - Xing, Xiaoyue AU - Xing X AD - Department of Medical Imaging, Beidaihe Rest and Recuperation Center of the Joint Logistics Support Force, PLA, Beidaihe City, Hebei Province, China. FAU - Wang, Zhe AU - Wang Z AD - Special Care Department, Beidaihe Rehabilitation and Recuperation Center, Joint Logistics Support Force, PLA, Beidaihe City, Hebei Province, China. FAU - Yang, Yuwei AU - Yang Y AD - Medical Department, Beidaihe Rest and Recuperation Center of the Joint Logistics Support Force, PLA, Beidaihe City, Hebei Province, China. FAU - Zhang, Lin AU - Zhang L AD - Medical Department, Beidaihe Rest and Recuperation Center of the Joint Logistics Support Force, PLA, Beidaihe City, Hebei Province, China. FAU - Yu, Weiguo AU - Yu W AUID- ORCID: 0009-0000-1821-7919 AD - Department of Medical Imaging, Beidaihe Rest and Recuperation Center of the Joint Logistics Support Force, PLA, Beidaihe City, Hebei Province, China. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Radiomics MH - *Intervertebral Disc Displacement/rehabilitation/diagnostic imaging MH - *Machine Learning MH - Middle Aged MH - Adult MH - Retrospective Studies MH - Recurrence MH - *Lumbar Vertebrae/diagnostic imaging MH - Female MH - Magnetic Resonance Imaging/methods MH - Male MH - Predictive Learning Models MH - Aged MH - Logistic Models MH - ROC Curve MH - Young Adult MH - Adolescent MH - Risk Factors PMC - PMC13574428 OTO - NOTNLM OT - lumbar disc herniation OT - machine learning OT - predictive model OT - radiomics OT - recurrence OT - rehabilitation COIS- The authors have no funding and conflicts of interest to declare. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/09/11 CRDT- 2026/09/15 03:20 PHST- 2025/12/02 00:00 [received] PHST- 2026/08/13 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:20 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - 00005792-202609110-00017 [pii] AID - MD-D-25-17232 [pii] AID - 10.1097/MD.0000000000050454 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Sep 11;105(37):e50454. doi: 10.1097/MD.0000000000050454. PMID- 42736577 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260915 LR - 20260916 IS - 2052-1847 (Print) IS - 2052-1847 (Electronic) IS - 2052-1847 (Linking) VI - 18 IP - 1 DP - 2026 Aug 18 TI - Effectiveness of virtual reality-based balance training in primary school children: a randomized controlled trial. LID - 10.1186/s13102-026-02006-y [doi] LID - 415 AB - Balance and coordination are fundamental for children's motor development and injury prevention, yet sedentary lifestyles have contributed to their decline. Conventional balance training can be effective, but maintaining children's engagement remains challenging. Virtual reality (VR)-based programs provide immersive and gamified practice and may offer an alternative way to deliver balance- and coordination-related training in schools. This six-week randomized controlled trial compared immersive VR-based training with conventional training in 129 primary school students (VR: n = 64; control: n = 65). Participants trained three times per week for 30 min per session. Balance and coordination were assessed pre- and post-intervention using the Y-Balance Test (YBT composite score) as the primary dynamic-balance outcome, alongside single-leg stance with eyes closed (SLST-EC) and a 1-minute rope-skipping test. Both groups showed significant pre-post improvements across all outcomes (all p < 0.001), but within-group rope-skipping changes were not reliably interpretable as training effects because of likely test-retest familiarization, and SLST-EC changes were constrained by ceiling effects. Between-group comparisons of change scores showed no statistically significant differences for DeltaYBT, DeltaSLST-EC, or Deltarope skipping (all p > 0.05). An ANCOVA adjusting for baseline YBT also showed no group effect on post-intervention YBT (p = 0.442). Overall, immersive VR did not show a statistically significant advantage over conventional training matched for scheduled frequency and session duration in this six-week school-based trial. Trial registration: ISRCTN Registry, ISRCTN37850916, registered on 30 June 2026. Retrospectively registered. CI - (c) 2026. The Author(s). FAU - Zhang, Hongfei AU - Zhang H AUID- ORCID: 0009-0003-7134-7757 AD - Gdansk University of Physical Education and Sport, Gdansk, 80-336, Poland. FAU - Hu, Wenjun AU - Hu W AD - Gdansk University of Physical Education and Sport, Gdansk, 80-336, Poland. FAU - Kortas, Jakub AU - Kortas J AD - Gdansk University of Physical Education and Sport, Gdansk, 80-336, Poland. jakub.kortas@awf.gda.pl. LA - eng PT - Journal Article DEP - 20260818 PL - England TA - BMC Sports Sci Med Rehabil JT - BMC sports science, medicine & rehabilitation JID - 101605016 PMC - PMC13573351 OTO - NOTNLM OT - Balance training OT - Child health promotion OT - Exercise intervention OT - Motor coordination OT - Virtual reality COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of Shanxi Engineering Vocational College (Ethics approval No. SEVC-2025-063). Written informed consent was obtained from the parents or legal guardians of all participating children before participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/18 CRDT- 2026/09/15 03:10 PHST- 2025/12/12 00:00 [received] PHST- 2026/08/14 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:10 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - 10.1186/s13102-026-02006-y [pii] AID - 2006 [pii] AID - 10.1186/s13102-026-02006-y [doi] PST - epublish SO - BMC Sports Sci Med Rehabil. 2026 Aug 18;18(1):415. doi: 10.1186/s13102-026-02006-y. PMID- 42736520 OWN - NLM STAT- Publisher LR - 20260915 IS - 1933-7205 (Electronic) IS - 1933-7191 (Linking) DP - 2026 Sep 14 TI - Circulating Fatty Acid-Binding Protein 4 (FABP4) in Adolescents with Polycystic Ovary Syndrome: Metabolic Correlates and Diagnostic Performance. LID - 10.1007/s43032-026-02189-2 [doi] AB - To compare circulating fatty acid-binding protein 4 (FABP4) concentrations in adolescents with polycystic ovary syndrome (PCOS) and controls, examine its metabolic correlates, and evaluate its diagnostic performance. This prospective observational study included 88 adolescents (44 PCOS, 44 controls) aged 10-19 years. PCOS was diagnosed using 2023 ESHRE/ASRM criteria. Clinical, anthropometric, and biochemical parameters were assessed. Serum FABP4 was measured via ELISA. Statistical analyses included multivariable linear regression, Firth's penalized logistic regression, and receiver operating characteristic (ROC) curves. Median FABP4 levels were significantly higher in adolescents with PCOS compared to controls (5.74 vs. 3.59 ng/mL, p < 0.001). Multivariable linear regression demonstrated that PCOS status, body mass index (BMI), and insulin resistance (HOMA-IR) associated with higher FABP4 concentrations. Multivariable logistic regression identified free androgen index (FAI) and FABP4 as variables independently associated with PCOS. ROC analysis showed FABP4 (> 4.08 ng/mL) yielded an area under the curve (AUC) of 0.849 (81.8% sensitivity, 75.0% specificity). The combination of FABP4 and FAI improved model discrimination compared with FAI alone (DeltaAUC = 0.133, p = 0.001), and this improvement remained significant after BMI adjustment. Circulating FABP4 is elevated in adolescents with PCOS and is associated with PCOS status, BMI, and insulin resistance. In this cohort, FABP4 provided complementary metabolic information when interpreted alongside FAI; however, BMI-matched, body composition-characterized, and externally validated studies are needed before FABP4 can be considered a clinically generalizable adjunctive biomarker in adolescent PCOS. CI - (c) 2026. The Author(s), under exclusive licence to Society for Reproductive Investigation. FAU - Codal, Bahadir AU - Codal B AUID- ORCID: 0000-0003-0044-9820 AD - Department of Obstetrics and Gynecology Bursa, Nev Anadolu Hospital, Nev Anadolu Hospital, 16110, Bursa, Turkiye. bahadrcodal@gmail.com. FAU - Kurt, Ahmet AU - Kurt A AUID- ORCID: 0000-0001-8402-5675 AD - Department of Obstetrics and Gynecology, Gemlik State Hospital, Bursa, Turkiye. FAU - Kaplan, Hacer AU - Kaplan H AUID- ORCID: 0009-0005-9240-4065 AD - Department of Obstetrics and Gynecology, Etlik City Hospital, Ankara, Turkiye. FAU - Cakir, Ayberk AU - Cakir A AUID- ORCID: 0000-0001-5749-4556 AD - Department of Obstetrics and Gynecology, Acibadem University Atakent Hospital, Istanbul, Turkiye. FAU - Hizli, Burak AU - Hizli B AUID- ORCID: 0009-0004-6060-1761 AD - School of Medicine, Department of Obstetrics and Gynecology, Usak University, Usak, Turkiye. FAU - Ozler, Mustafa Rasit AU - Ozler MR AUID- ORCID: 0000-0001-5911-6786 AD - Department of Perinatology, Bursa City Hospital, Bursa, Turkiye. LA - eng PT - Journal Article DEP - 20260914 PL - United States TA - Reprod Sci JT - Reproductive sciences (Thousand Oaks, Calif.) JID - 101291249 SB - IM OTO - NOTNLM OT - Adipokines OT - Adolescent OT - Biomarkers OT - Fatty acid-binding protein 4 OT - Hyperandrogenism OT - Insulin resistance OT - Polycystic ovary syndrome COIS- Declarations. Ethics Approval and Consent to Participate: The study protocol was approved by the Acibadem Mehmet Ali Aydinlar University Medical Research Evaluation Commission (ATADEK) (Approval No: ATADEK-2026-01/07). The study was conducted in accordance with the Declaration of Helsinki. Written informed consent was obtained from all participants and their legal guardians prior to enrollment. Consent for Publication: The authors declare that they agree to publication. Conflict of interest: The authors declare that there is no conflict of interest regarding the publication of this article. No financial or personal relationships exist that could inappropriately influence or bias the content of the work. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:36 CRDT- 2026/09/15 02:51 PHST- 2026/03/17 00:00 [received] PHST- 2026/08/15 00:00 [accepted] PHST- 2026/09/15 05:36 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 02:51 [entrez] AID - 10.1007/s43032-026-02189-2 [pii] AID - 10.1007/s43032-026-02189-2 [doi] PST - aheadofprint SO - Reprod Sci. 2026 Sep 14. doi: 10.1007/s43032-026-02189-2. PMID- 42734924 OWN - NLM STAT- MEDLINE DCOM- 20260914 LR - 20260914 IS - 1873-5843 (Electronic) IS - 0887-6177 (Linking) VI - 41 IP - 7 DP - 2026 Sep 9 TI - Characterizing neuropsychological performance and its nutritional, visual, and physiological correlates in children. LID - acag071 [pii] LID - 10.1093/arclin/acag071 [doi] AB - OBJECTIVE: To characterize neuropsychological performance in Ghanaian preadolescent children and examine its associations with demographic, health, nutritional, and visual factors. METHODS: A cross-sectional study was conducted among 290 preadolescent school children (median age: 11.0 years [IQR: 2.0]; range: 8-11 years; 54.8% female) from urban and rural public and private schools in the Ashanti Region of Ghana. Neuropsychological function was assessed using the Cambridge Neuropsychological Test Automated Battery, covering memory, executive function, attention, and psychomotor domains (minimum analytical sample: n = 150). Spearman's rank correlations assessed convergent validity and domain-specific independence. Associations between participant characteristics and cognitive performance were examined using multivariable linear regression, with Benjamini-Hochberg false discovery rate (FDR) correction applied across all regression tests. Statistical significance was defined as an FDR-adjusted q < 0.05, whereas both unadjusted p-values and adjusted q-values were reported for transparency. RESULTS: Cognitive performance exhibited a predominantly modular structure, characterized by strong within-task coherence and limited cross-domain integration. Males performed better than females on visual learning and psychomotor speed tasks, particularly Paired Associates Learning and movement reaction time measures (p < .05), whereas simple reaction time did not differ between sexes (p > .05). Following Benjamini-Hochberg FDR correction, no associations between cognitive performance and demographic, health, nutritional, or visual factors remained statistically significant. CONCLUSION: Neuropsychological functioning in Ghanaian preadolescent children appears to be predominantly modular, with limited evidence that demographic, health, nutritional, or visual factors are independently associated with cognitive performance after correction for multiple comparisons. CI - (c) The Author(s) 2026. Published by Oxford University Press. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Osei Duah Junior, Isaiah AU - Osei Duah Junior I AUID- ORCID: 0000-0003-4501-8602 AD - Department of Optometry and Visual Science, College of Science, PMB, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. AD - Department of Psychology, John R. and Kathy R. Hairston College of Health and Human Sciences, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, United States of America. FAU - Ashon, Nana Aba Senuwah AU - Ashon NAS AUID- ORCID: 0009-0009-4618-8321 AD - Department of Optometry and Visual Science, College of Science, PMB, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. FAU - Ofori-Asare, Wendy AU - Ofori-Asare W AUID- ORCID: 0009-0001-2401-9561 AD - Department of Optometry and Visual Science, College of Science, PMB, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. FAU - Johnson, Elizabeth J AU - Johnson EJ AUID- ORCID: 0000-0002-8508-0032 AD - Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, United States of America. FAU - Amoako, Mary AU - Amoako M AUID- ORCID: 0000-0001-9387-2286 AD - Department of Biochemistry and Biotechnology, College of Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. FAU - Adu-Owusu, Dorcas AU - Adu-Owusu D AUID- ORCID: 0009-0000-7594-3626 AD - Department of Biochemistry and Biotechnology, College of Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. FAU - Boateng, Josephine Ampomah AU - Boateng JA AUID- ORCID: 0009-0004-3522-5012 AD - Department of Optometry and Visual Science, College of Science, PMB, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. FAU - Boateng, Charllote AU - Boateng C AUID- ORCID: 0009-0009-3778-1318 AD - Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, The University of Memphis, Memphis, TN 38152, United States of America. FAU - Akuffo, Kwadwo Owusu AU - Akuffo KO AD - Department of Optometry and Visual Science, College of Science, PMB, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. LA - eng GR - N.A.S.A./ PT - Journal Article PL - United States TA - Arch Clin Neuropsychol JT - Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists JID - 9004255 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - *Neuropsychological Tests MH - Cross-Sectional Studies MH - *Psychomotor Performance/physiology MH - *Executive Function/physiology MH - *Attention/physiology MH - Ghana MH - Processing Speed MH - *Cognition/physiology MH - Memory/physiology MH - *Nutritional Status/physiology MH - *Visual Perception/physiology MH - Reaction Time/physiology OTO - NOTNLM OT - attention OT - cognitive enhancements OT - executive functions OT - gender effects OT - learning and memory OT - perception/spatial processing EDAT- 2026/09/14 17:40 MHDA- 2026/09/14 17:41 CRDT- 2026/09/14 11:33 PHST- 2026/03/30 00:00 [received] PHST- 2026/08/08 00:00 [revised] PHST- 2026/08/14 00:00 [accepted] PHST- 2026/09/14 17:41 [medline] PHST- 2026/09/14 17:40 [pubmed] PHST- 2026/09/14 11:33 [entrez] AID - 8793661 [pii] AID - 10.1093/arclin/acag071 [doi] PST - ppublish SO - Arch Clin Neuropsychol. 2026 Sep 9;41(7):acag071. doi: 10.1093/arclin/acag071. PMID- 42734311 OWN - NLM STAT- MEDLINE DCOM- 20260914 LR - 20260914 IS - 1970-7096 (Electronic) IS - 1827-1987 (Linking) VI - 21 IP - 2 DP - 2026 Jul 23 TI - Household-level spatial modelling of child height-for-age in Northern Province, Rwanda: comparison of geographically weighted and neural network weighted regression models. LID - 10.4081/gh.2026.1491 [doi] AB - Childhood stunting remains a major public health concern in low- and middle-income countries, with persistent sub-national disparities. This study examined spatially varying associations between Height-for-Age z-scores (HAZ) and selected child, maternal, and household factors, and compared Geographically Weighted Regression (GWR), Multi-scale GWR (MGWR) and Geographically Neural Network Weighted Regression (GNNWR) in their ability to capture spatial heterogeneity and non-linearity. We analysed data from a cross-sectional survey conducted in December 2021 in the Northern Province of Rwanda. The survey covered 615 households, with analyses performed for 601 children aged 1-36 months. After imputation, multicollinearity screening, and feature selection, HAZ was modelled using Ordinary Least Squares (OLS), GWR, MGWR and GNNWR. Model performance was assessed using coefficient of determination (R2), Root Mean Square Error (RMSE), Akaike Information Criterion/AIC Corrected (AIC/AICc), and Moran's I of residuals. Overall stunting prevalence was 27.1%. Spatially varying associations were observed for child age, sex, birthweight, underweight status, selected childcare practices, maternal support, and household living conditions. GNNWR achieved the best training performance (R2 = 0.66; RMSE=0.74) followed by MGWR (R2 =0.51; RMSE=0.88) and GWR (R2 =0.43; RMSE=0.95). Validation performance declined for all models, although GNNWR retained a higher validation (R2=0.28) with negligible residual spatial autocorrelation (Moran's I = -0.005). GNNWR provided the strongest overall fit among the compared models and highlighted local spatial variation in associations with HAZ. However, the modest validation performance indicates that the findings should be interpreted cautiously. The workflow offers a portable framework for analysing DHS-like geocoded household datasets, but broader applicability should be assessed using spatial cross-validation, and sensitivity analyses. FAU - Kagoyire, Clarisse AU - Kagoyire C AD - Department of Earth and Environmental Sciences, Lund University, Lund, Sweden; Centre for GIS and Remote Sensing, College of Science and Technology, University of Rwanda, Kigali. FAU - Nduwayezu, Gilbert AU - Nduwayezu G AD - Department of Earth and Environmental Sciences, Lund University, Lund, Sweden; Department of Civil, Environmental and Geomatics Engineering, College of Science and Technology, University of Rwanda, Kigali. FAU - Oucheikh, Rachid AU - Oucheikh R AD - Department of Earth and Environmental Sciences, Lund University, Lund. FAU - Bizimana, Jean Pierre AU - Bizimana JP AD - Department of Spatial Planning, School of Architecture and Built Environment, College of Science and Technology, University of Rwanda, Kigali. FAU - Pilesjo, Petter AU - Pilesjo P AD - Lund University, Lund, Sweden. FAU - Mansourian, Ali AU - Mansourian A AD - Department of Earth and Environmental Sciences, Lund University, Lund. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260914 PL - Italy TA - Geospat Health JT - Geospatial health JID - 101302943 SB - IM MH - Humans MH - Rwanda/epidemiology MH - Cross-Sectional Studies MH - Female MH - Infant MH - Male MH - *Body Height MH - Child, Preschool MH - *Growth Disorders/epidemiology MH - *Family Characteristics MH - *Neural Networks, Computer MH - *Spatial Analysis MH - *Spatial Regression OTO - NOTNLM OT - Child height-for-age OT - Rwanda OT - childhood stunting OT - geographically weighted regression OT - spatial heterogeneity EDAT- 2026/09/14 11:40 MHDA- 2026/09/14 11:41 CRDT- 2026/09/14 08:42 PHST- 2026/01/28 00:00 [received] PHST- 2026/03/29 00:00 [accepted] PHST- 2026/09/14 11:41 [medline] PHST- 2026/09/14 11:40 [pubmed] PHST- 2026/09/14 08:42 [entrez] AID - 10.4081/gh.2026.1491 [doi] PST - ppublish SO - Geospat Health. 2026 Jul 23;21(2). doi: 10.4081/gh.2026.1491. Epub 2026 Sep 14. PMID- 42731058 OWN - NLM STAT- Publisher LR - 20260912 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) DP - 2026 Sep 12 TI - Does the British Columbia Farmers' Market Nutrition Coupon Program improve the diet quality and food security of parents and children with lower incomes? Protocol for a dose-response, pragmatic randomized controlled trial. PG - 2601060261473062 LID - 10.1177/02601060261473062 [doi] AB - BackgroundThe British Columbia Farmers' Market Nutrition Coupon Program (FMNCP) provides lower-income households with coupons to purchase healthy foods at farmers' markets.AimThis pragmatic randomized controlled trial (RCT) will examine the effectiveness and cost-effectiveness of two higher subsidies for healthy food, compared to the usual FMNCP healthy food subsidy, on the diet quality (primary outcome), food insecurity, and other health-related outcomes of 276 parent-child dyads with lower incomes.MethodsIn this single-blind, three-arm, parallel-group pragmatic RCT, 276 parent-child dyads in lower-income households will be randomized to receive the usual FMNCP healthy food subsidy ($27/week) or a subsidy that is two ($54/week) or three times ($81/week) higher. Participants will receive 16 weeks of coupons that can be redeemed for up to 20 weeks. Outcomes will be assessed in one parent (18-64 years) and child (6-17 years) from each household pre-, mid-, and post-intervention. Dietary intake will be collected via two 24-h dietary recalls at each time point to calculate diet quality using the Healthy Eating Food Index-2019. Food insecurity and other health-related outcomes will be assessed using validated self-reported instruments. Mixed effects regression will assess the effects of the interventions, relative to the usual subsidy, on outcomes in parents and children. A full incremental analysis will quantify the cost-effectiveness ratios of the healthy food subsidies.SummaryThis dose-response RCT will show how the diet quality, food insecurity, and other health-related outcomes of parents and children vary according to subsidy amount.Trial registrationThe trial is registered at www.clinicaltrials.gov (NCT06992947). FAU - Olstad, Dana Lee AU - Olstad DL AUID- ORCID: 0000-0001-9787-9952 AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 FAU - Campbell, David Jt AU - Campbell DJ AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 AD - Department of Medicine, Cumming School of Medicine, University of Calgary Foothills Medical Centre-North Tower, Calgary, AB, Canada. AD - Department of Cardiac Sciences, Cumming School of Medicine, Calgary, AB, Canada. FAU - Sajobi, Tolulope T AU - Sajobi TT AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 FAU - O'Hara, Heather AU - O'Hara H AD - British Columbia Association of Farmers' Markets, Vancouver, BC, Canada. RINGGOLD: 576770 FAU - Leblanc, Peter AU - Leblanc P AD - British Columbia Association of Farmers' Markets, Vancouver, BC, Canada. RINGGOLD: 576770 FAU - McCormack, Gavin R AU - McCormack GR AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 FAU - Radin-Pereira, Leticia AU - Radin-Pereira L AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 FAU - Lee, Yun Yun AU - Lee YY AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 FAU - Aktary, Michelle L AU - Aktary ML AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 FAU - Minaker, Leia M AU - Minaker LM AD - Future Cities Institute, School of Planning, University of Waterloo, Waterloo, ON, Canada. RINGGOLD: 8430 FAU - Spackman, Eldon AU - Spackman E AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 LA - eng SI - ClinicalTrials.gov/NCT06992947 PT - Journal Article DEP - 20260912 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 SB - IM OTO - NOTNLM OT - Randomized controlled trial OT - adults OT - children OT - diet quality OT - dose-response OT - farmers' market OT - food insecurity OT - healthy food subsidy OT - lower-income OT - parental shielding EDAT- 2026/09/13 00:50 MHDA- 2026/09/13 00:50 CRDT- 2026/09/12 13:03 PHST- 2026/09/13 00:50 [medline] PHST- 2026/09/13 00:50 [pubmed] PHST- 2026/09/12 13:03 [entrez] AID - 10.1177/02601060261473062 [doi] PST - aheadofprint SO - Nutr Health. 2026 Sep 12:2601060261473062. doi: 10.1177/02601060261473062. PMID- 42730602 OWN - NLM STAT- Publisher LR - 20260921 IS - 1365-2516 (Electronic) IS - 1351-8216 (Linking) DP - 2026 Sep 12 TI - Living With Factor VII Deficiency-A Mixed Methods Study. LID - 10.1111/hae.70404 [doi] AB - BACKGROUND: Factor VII deficiency (FVIID) is a rare autosomal recessive disorder, resulting in potentially unpredictable and life-threatening bleeding. The prevalence of symptomatic patients is 1 in 300,000. Treatment is mostly given following bleeding, but those with the lowest levels may be offered prophylaxis. OBJECTIVES: We aimed to explore the real-life impact of FVIID on individuals and their families, focusing on psychosocial wellbeing and quality of life (QoL). METHODS: The study used a quantitative survey, including validated QoL tools, and qualitative one-to-one interviews to enable deeper exploration of the quantitative findings. RESULTS: One hundred people with FVIID (74 adults; 26 caregivers of children) completed the survey; 24 (18 adults; 6 caregivers) were interviewed. A significant gender-based disparity was observed: males were diagnosed at a median age of 4 years, versus 17 years in females (p < 0.001). 56% of respondents reported a mean of 1.25 bleeds per week; significantly higher in women than men (mean 1.65 vs. 0.53/week, respectively; p < 0.01). QoL scores decreased with increased bleeding measured by the self-BAT (p < 0.001). Bleeding was associated with significant social impact: missed physical activity (64%), avoidance of social engagements (53%) and lost education (50%). Interviews yielded six core themes associated with unmet need. CONCLUSION: FVIID causes significant challenges, disproportionately borne by women and compounded by gaps in management, especially treatment. Current treatments are burdensome and fail to prevent breakthrough bleeds. People with FVIID have unmet needs that require therapeutic innovation, improved diagnosis and management strategies, and data collection to improve their QoL and outcomes. CI - (c) 2026 The Author(s). Haemophilia published by John Wiley & Sons Ltd. FAU - Fletcher, Simon AU - Fletcher S AD - Haemnet Ltd, London, UK. FAU - Boyton, Matthew AU - Boyton M AD - Haemnet Ltd, London, UK. FAU - Bristow, Sam AU - Bristow S AD - Haemnet Ltd, London, UK. FAU - Khair, Kate AU - Khair K AD - Haemnet Ltd, London, UK. LA - eng GR - Hemab Therapeutics/ PT - Journal Article DEP - 20260912 PL - England TA - Haemophilia JT - Haemophilia : the official journal of the World Federation of Hemophilia JID - 9442916 SB - IM OTO - NOTNLM OT - factor VII deficiency OT - mixed methods OT - natural history OT - quality of life OT - unmet need EDAT- 2026/09/13 00:50 MHDA- 2026/09/13 00:50 CRDT- 2026/09/12 08:23 PHST- 2026/08/31 00:00 [revised] PHST- 2026/05/27 00:00 [received] PHST- 2026/09/04 00:00 [accepted] PHST- 2026/09/13 00:50 [pubmed] PHST- 2026/09/13 00:50 [medline] PHST- 2026/09/12 08:23 [entrez] AID - 10.1111/hae.70404 [doi] PST - aheadofprint SO - Haemophilia. 2026 Sep 12. doi: 10.1111/hae.70404. PMID- 42730388 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260912 LR - 20260914 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 8 DP - 2026 Aug TI - Academic- and Family-Related Correlates of Anxiety Among College-Going Adolescents in Central India: A Cross-Sectional Study. PG - e114386 LID - 10.7759/cureus.114386 [doi] LID - e114386 AB - BACKGROUND: Anxiety is the most common mental health disorder among adolescents worldwide. In India, intense academic competition and evolving family dynamics add to this burden, yet systematic data from smaller central Indian districts are scarce. OBJECTIVE: This study aims to determine the prevalence and severity of anxiety among college-going adolescents aged 17-19 years in Ratlam district, Madhya Pradesh, and to examine its association with academic- and family-related factors. METHODS: In this cross-sectional observational study, 550 first-year students were enrolled from 10 colleges (five professional, five nonprofessional) through multistage random sampling between June 2023 and November 2024. Depression, anxiety, and stress were measured with the validated Depression Anxiety Stress Scale-21 (DASS-21). Family-related factors included family type, parental marital status, sibling count, and paternal education, while academic-related factors included college type. Associations were assessed with the chi-square test and Cramer's V, and factors independently associated with clinically significant anxiety were assessed using binary logistic regression, yielding adjusted odds ratios (AORs) with 95% confidence intervals (CIs), using R (version 4.3); p < 0.05 was considered significant. RESULTS: Clinically significant anxiety was recorded in 178 participants (32.36%) (mild: 110 (20.00%); moderate: 57 (10.36%); severe: 11 (2.00%)), making anxiety the most prevalent DASS-21 domain ahead of stress (116; 21.09%) and depression (62; 11.28%). On multivariable analysis, female sex (AOR: 2.26; 95% CI: 1.45-3.52; p < 0.001), professional-college enrolment (AOR: 1.45; 95% CI: 1.05-2.01; p = 0.024), and hostel residence (AOR: 1.68; 95% CI: 1.15-2.45; p = 0.007) were independently associated with higher odds of clinically significant anxiety, whereas joint-family structure was associated with lower odds (AOR: 0.62; 95% CI: 0.42-0.91; p = 0.015). Nuclear-family students showed the highest anxiety prevalence (113 of 301; 37.54%) compared with joint-family students (59 of 230; 25.70%). Music (226; 41.09%) and social connection (95; 17.27%) were the most frequently used coping strategies, whereas physical exercise was rarely used (8; 1.45%). CONCLUSIONS: Academic- and family-related factors were associated with anxiety among college-going adolescents. These findings support the need for campus-based mental-health screening, accessible counselling services, and promotion of healthy coping strategies, including physical activity. CI - Copyright (c) 2026, Chawla et al. FAU - Chawla, Heena AU - Chawla H AD - Community Medicine, Dr. Laxminarayan Pandey Government Medical College, Ratlam, IND. FAU - Sinha, Umesh AU - Sinha U AD - Community Medicine, Dr. Laxminarayan Pandey Government Medical College, Ratlam, IND. FAU - Agriya, Rajkumar AU - Agriya R AD - Community Medicine, Dr. Laxminarayan Pandey Government Medical College, Ratlam, IND. FAU - Ranasaria, Hitesh AU - Ranasaria H AD - Orthopedics, Virendra Kumar Sakhlecha Government Medical College, Neemuch, IND. LA - eng PT - Journal Article DEP - 20260811 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13566112 OTO - NOTNLM OT - academic factors OT - adolescent anxiety OT - college students OT - cross-sectional study OT - dass-21 OT - family factors OT - mental health COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Government Autonomous Medical College, Ratlam issued approval GMC/RATLAM/2023/IEC/Approval/09. The institutional ethics committee meeting held on 27.05.2023 and 28.05.2023 approved the research project entitled "Assessment of Mental Well-being and its correlates in college-going adolescents (17-19 years) of Ratlam District. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/09/13 00:50 MHDA- 2026/09/13 00:51 PMCR- 2026/08/11 CRDT- 2026/09/12 08:04 PHST- 2026/08/11 00:00 [accepted] PHST- 2026/09/13 00:51 [medline] PHST- 2026/09/13 00:50 [pubmed] PHST- 2026/09/12 08:04 [entrez] PHST- 2026/08/11 00:00 [pmc-release] AID - 10.7759/cureus.114386 [doi] PST - epublish SO - Cureus. 2026 Aug 11;18(8):e114386. doi: 10.7759/cureus.114386. eCollection 2026 Aug. PMID- 42729466 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260912 LR - 20260914 IS - 2451-8654 (Electronic) IS - 2451-8654 (Linking) VI - 53 DP - 2026 Oct TI - From Kitchen to Clinic: Study protocol for a family-centered, food-as-medicine approach using medically tailored meals and caregiver coaching in pediatric oncology care. PG - 101681 LID - 10.1016/j.conctc.2026.101681 [doi] LID - 101681 AB - BACKGROUND: Children undergoing cancer treatment are at high risk for malnutrition, poor diet quality, and early cardiometabolic risk due to treatment-related side effects, disrupted appetite, and household-level barriers to healthy eating. Caregivers play a central role in nutritional support during treatment but often experience substantial burden, time constraints, and nutrition insecurity. Food-as-medicine strategies, including medically tailored meals (MTMs), have shown promise in adult populations but remain underexplored in pediatric oncology, particularly during active treatment and within family-centered models. OBJECTIVE: The primary objective of this study is to evaluate the feasibility, acceptability, and adherence of From Kitchen to Clinic, a 12-week, family-centered food-as-medicine intervention that integrates MTM delivery with caregiver coaching for caregivers of children undergoing cancer treatment. Secondary objectives include collecting exploratory data on patient dietary intake, weight and lean body mass trajectories, treatment tolerance, household food and nutrition security, and caregiver burden and distress to inform a future definitive trial. METHODS: This prospective, single-arm feasibility study will enroll 60 caregiver-child dyads (N = 120) recruited from three outpatient pediatric oncology clinics at a large children's hospital. The 12-week intervention includes an intensive phase (weeks 1-8) with weekly MTM delivery and caregiver coaching, followed by a tapered phase (weeks 9-12) with reduced meal frequency and bi-weekly coaching. Feasibility outcomes include recruitment, retention, assessment completion, intervention adherence, and acceptability, evaluated against predefined progression criteria. Exploratory outcomes will be assessed at baseline and at 3, 6, and 12 months post-intervention using validated dietary, anthropometric, clinical, and caregiver-reported measures. TRIAL REGISTRATION: NCT07454902. CI - (c) 2026 The Authors. Published by Elsevier Inc. FAU - Milliron, Brandy-Joe AU - Milliron BJ AD - Department of Health Sciences, College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA. FAU - Schlechter, Haley AU - Schlechter H AD - Children's Hospital of Philadelphia, King of Prussia, PA, USA. FAU - Muir, Cass AU - Muir C AD - The Center for Childhood Cancer Research, Supportive Care in Oncology Research (SCORe) Program, Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Moss, Cynthia AU - Moss C AD - The Center for Childhood Cancer Research, Supportive Care in Oncology Research (SCORe) Program, Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Henstenburg, Jule Anne AU - Henstenburg JA AD - MANNA Institute, Metropolitan Area Neighborhood Nutrition Alliance, Philadelphia, PA, USA. FAU - Rappaport, Kylee AU - Rappaport K AD - Department of Health Sciences, College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA. FAU - Boakye, Faustina AU - Boakye F AD - Department of Health Sciences, College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA. FAU - Deutsch, Jonathan M AU - Deutsch JM AD - Department of Health Sciences, College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA. FAU - Jubelirer, Tracey AU - Jubelirer T AD - Department of Pediatrics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA. AD - Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA. LA - eng SI - ClinicalTrials.gov/NCT07454902 PT - Journal Article DEP - 20260829 PL - Netherlands TA - Contemp Clin Trials Commun JT - Contemporary clinical trials communications JID - 101671157 PMC - PMC13562409 OTO - NOTNLM OT - Caregiving OT - Feasibility OT - Food as medicine OT - Medically tailored meals OT - Nutrition OT - Pediatric oncology OT - Survivorship COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/13 00:50 MHDA- 2026/09/13 00:51 PMCR- 2026/08/29 CRDT- 2026/09/12 06:51 PHST- 2026/03/18 00:00 [received] PHST- 2026/08/19 00:00 [revised] PHST- 2026/08/29 00:00 [accepted] PHST- 2026/09/13 00:51 [medline] PHST- 2026/09/13 00:50 [pubmed] PHST- 2026/09/12 06:51 [entrez] PHST- 2026/08/29 00:00 [pmc-release] AID - S2451-8654(26)00088-8 [pii] AID - 101681 [pii] AID - 10.1016/j.conctc.2026.101681 [doi] PST - epublish SO - Contemp Clin Trials Commun. 2026 Aug 29;53:101681. doi: 10.1016/j.conctc.2026.101681. eCollection 2026 Oct. PMID- 42724426 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260911 LR - 20260912 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 8 DP - 2026 Aug 31 TI - Is there an association between dietary fiber intake, screen time, and physical activity among students aged 14 to 17 years?-a cross-sectional study. PG - 299 LID - 10.21037/tp-2026-0432 [doi] LID - 299 AB - BACKGROUND: Concerns about the impact of screen time, unbalanced diet, and declining physical activity (PA) on health are increasing. Therefore, the aim of the present study was to examine the association between screen time, PA and dietary behavior, with a special consideration of fiber intake in adolescents. METHODS: The study is based on cross-sectional data including 410 Austrian adolescents (54.6% girls) with an average age of 15.7+/-1.0 years. Daily fiber intake was determined using a validated screening instrument (18-item Fiber-Screen). In addition, participants reported average hours per week of leisure-time PA including club sport activities and daily screen time [mobile phone, computer and television (TV)] via a questionnaire. RESULTS: The average fiber intake per day was 14.49 g/day, less than the international recommendations of at least 25 g of fiber per day. Girls got more of their fiber from vegetables and legumes, while boys consumed more bread and potatoes. Regression analyses showed that both PA (beta =0.257) and screen time, particularly computer (beta =-0.144) and TV time (beta =-0.138) are independently associated with fiber intake (P<0.001). Furthermore, sports club members had a significantly higher daily fiber intake than non-sports club members (16.1+/-6.7 vs. 12.8+/-4.6 g/d; P<0.001). Sports club participation was also associated with higher PA levels (40.0% vs. 15.0% reported >3 h/week) less time on the computer (51.0% vs. 33.0% reported <1 h/d) compared to non-sports club members (P<0.001) but there was no significant difference in mobile phone use and TV time. CONCLUSIONS: The present results show that low fiber intake is widespread among adolescents and that longer screen time and low PA are associated with a low fiber intake, which indicates a clustering of health behaviors. Accordingly, intervention strategies may target several behaviors to promote health in youth. CI - (c) AME Publishing Company. FAU - Greier, Carla AU - Greier C AD - Department of Sports Science, University of Innsbruck, Innsbruck, Austria. FAU - Drenowatz, Clemens AU - Drenowatz C AUID- ORCID: 0000-0002-3861-5364 AD - Division of Sport, Physical Activity and Health, University of Education Upper Austria, Linz, Austria. FAU - Dudas, Jozsef AU - Dudas J AD - Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Innsbruck, Innsbruck, Austria. FAU - Ruedl, Gerhard AU - Ruedl G AD - Department of Sports Science, University of Innsbruck, Innsbruck, Austria. FAU - Posch, Markus AU - Posch M AD - Division of Physical Education, Private University of Education (KPH-ES), Stams, Austria. FAU - Greier, Klaus AU - Greier K AD - Department of Sports Science, University of Innsbruck, Innsbruck, Austria. LA - eng PT - Journal Article DEP - 20260827 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13559115 OTO - NOTNLM OT - Diet OT - computer time OT - media use OT - sports OT - television time (TV time) COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0432/coif). C.D. serves as an unpaid editorial board member of Translational Pediatrics from May 2026 to December 2027. The other authors have no conflicts of interest to declare. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2026/08/31 CRDT- 2026/09/11 09:35 PHST- 2026/05/04 00:00 [received] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 09:35 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - tp-15-08-299 [pii] AID - 10.21037/tp-2026-0432 [doi] PST - ppublish SO - Transl Pediatr. 2026 Aug 31;15(8):299. doi: 10.21037/tp-2026-0432. Epub 2026 Aug 27. PMID- 42724397 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260911 LR - 20260912 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 8 DP - 2026 Aug 31 TI - Clinical factors associated with extrapulmonary complications in children with macrolide-resistant Mycoplasma pneumoniae pneumonia: a single-center retrospective matched case-control study. PG - 309 LID - 10.21037/tp-2026-0451 [doi] LID - 309 AB - BACKGROUND: Extrapulmonary complications contribute substantially to the clinical burden of macrolide-resistant Mycoplasma pneumoniae pneumonia (R-MPP), but factors associated with these events and their combined discriminatory value remain insufficiently characterized. This study examined clinical, laboratory, radiographic, and treatment-related factors associated with extrapulmonary complications and developed a simplified classification model. METHODS: This single-center retrospective matched case-control study included children aged 3-14 years hospitalized between January 2021 and June 2024. Among 684 potentially eligible children identified from electronic medical record and microbiology databases, 448 met the criteria for genotypically confirmed R-MPP. All 52 children who developed extrapulmonary complications during the index hospitalization were included as cases. From 396 children without complications, 156 controls were individually matched at a 1:3 ratio by sex, age within 6 months, and admission date within 30 days. Candidate variables included peak inflammatory biomarkers, nadir platelet count, respiratory and computed tomography (CT) severity, and intervals from symptom onset to medical consultation and macrolide initiation. Complete-case conditional logistic regression stratified by matched set was the primary analysis; least absolute shrinkage and selection operator (LASSO) was used for variable selection, and multiple imputation was performed as a sensitivity analysis. RESULTS: Cases and controls were comparable in age, sex, admission period, nutritional status, residence, vaccination status, household tobacco exposure, and wheezing history. C-reactive protein (CRP) >100 mg/L [matched odds ratio (OR) =3.28; 95% confidence interval (CI): 1.70-6.34], lactate dehydrogenase (LDH) >400 U/L (OR =2.97; 95% CI: 1.56-5.65), macrolide initiation delay >7 days (OR =4.18; 95% CI: 2.16-8.08), and severe CT changes (OR =2.15; 95% CI: 1.08-4.29) were independently associated with complications. A three-variable model incorporating CRP, LDH, and macrolide delay achieved an optimism-corrected area under the receiver operating characteristic (ROC) curve (AUC) of 0.917, with 86.5% sensitivity and 88.5% specificity. A preliminary internal temporal assessment in 44 patients yielded an AUC of 0.892. CONCLUSIONS: Elevated CRP, elevated LDH, delayed macrolide initiation, and severe CT changes were associated with extrapulmonary complications in hospitalized children with R-MPP. The simplified model may support clinical classification, but the retrospective design, concurrent biomarker measurement, and limited temporal sample preclude causal interpretation or immediate implementation. Larger multicenter studies are required for formal validation. CI - (c) AME Publishing Company. FAU - Xu, Tianfu AU - Xu T AD - Department of Pediatrics, The Affiliated Hospital (Group) of Putian University, Putian, China. FAU - Yan, Seyan AU - Yan S AD - Department of Pediatrics, The Affiliated Hospital (Group) of Putian University, Putian, China. FAU - Huang, Saiping AU - Huang S AD - Department of Pediatrics, The Affiliated Hospital (Group) of Putian University, Putian, China. LA - eng PT - Journal Article DEP - 20260730 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13559145 OTO - NOTNLM OT - Macrolide-resistant Mycoplasma pneumoniae pneumonia (R-MPP) OT - classification model OT - extrapulmonary complications OT - pediatric pneumonia OT - treatment delay COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0451/coif). The authors have no conflicts of interest to declare. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2026/08/31 CRDT- 2026/09/11 09:32 PHST- 2026/05/09 00:00 [received] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 09:32 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - tp-15-08-309 [pii] AID - 10.21037/tp-2026-0451 [doi] PST - ppublish SO - Transl Pediatr. 2026 Aug 31;15(8):309. doi: 10.21037/tp-2026-0451. Epub 2026 Jul 30. PMID- 42724349 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260911 LR - 20260912 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 8 DP - 2026 Aug 31 TI - Whole-exome sequencing-centered genetic evaluation for early-onset obesity in Chinese children: a retrospective single-center cohort. PG - 330 LID - 10.21037/tp-2026-0407 [doi] LID - 330 AB - BACKGROUND: Genetic causes of early-onset obesity remain undercharacterized in East Asian children. This study evaluated a whole-exome sequencing (WES)-centered diagnostic workflow in Chinese children with obesity onset before 5 years. METHODS: Consecutive children with body mass index above the 95th percentile and obesity onset before 5 years who completed structured inpatient assessment at a single center between February 2022 and December 2023 were retrospectively analyzed. Phenotyping included clinical, biochemical, oral glucose tolerance, cortisol rhythm, and liver assessments. Genetic testing combined WES, mitochondrial DNA analysis, multiplex ligation-dependent probe amplification (MLPA) for obesity-related imprinting loci, WES-based copy-number variant and runs-of-homozygosity analyses, and Sanger validation. Variants were interpreted according to the American College of Medical Genetics and Genomics/Association for Molecular Pathology (ACMG/AMP) criteria. RESULTS: Among 23 children, clinically relevant genetic findings were identified in 6 (26.1%): melanocortin-4 receptor (MC4R) c.831T>A (p.C277*), maternal uniparental disomy of 15q11-13, and four phenotype-correlated variants of uncertain significance in UCP3, BBS1, NCOA1, and SH2B1. The definitive/likely diagnostic yield, restricted to pathogenic or confirmed imprinting findings, was 8.7% (2/23). Findings involved leptin-MC4R signaling, BBSome function, fatty-acid oxidation, and chromosomal imprinting. Genetically positive children showed numerically higher alanine aminotransferase (ALT) and aspartate aminotransferase (AST), but differences were not statistically significant. BBS1 p.T374S was relatively enriched in East Asian reference data. CONCLUSIONS: A WES-centered integrated workflow detected heterogeneous genetic mechanisms in Chinese children with early-onset obesity, but variant of uncertain significance (VUS)-associated findings should be distinguished from confirmed diagnoses. Orthogonal methylation/MLPA and runs of homozygosity (ROH) analyses were necessary for imprinting diagnosis. Larger multicenter studies and functional validation are needed. CI - (c) AME Publishing Company. FAU - Chen, Si AU - Chen S AD - Department of Endocrinology, Genetics and Metabolism, Chengdu Women's and Children's Center Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Zhang, Jing AU - Zhang J AD - Department of Endocrinology, Genetics and Metabolism, Chengdu Women's and Children's Center Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Ge, Liyuan AU - Ge L AD - Department of Endocrinology, Genetics and Metabolism, Chengdu Women's and Children's Center Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Li, Zhonghui AU - Li Z AD - Department of Endocrinology, Genetics and Metabolism, Chengdu Women's and Children's Center Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Wang, Liuxu AU - Wang L AD - Department of Endocrinology, Genetics and Metabolism, Chengdu Women's and Children's Center Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Cheng, Xinran AU - Cheng X AUID- ORCID: 0000-0001-9001-4016 AD - Department of Endocrinology, Genetics and Metabolism, Chengdu Women's and Children's Center Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. LA - eng PT - Journal Article DEP - 20260722 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13559094 OTO - NOTNLM OT - Chinese children OT - Early-onset obesity OT - genetic diagnosis OT - monogenic obesity OT - whole-exome sequencing (WES) COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0407/coif). The authors have no conflicts of interest to declare. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2026/08/31 CRDT- 2026/09/11 09:28 PHST- 2026/04/23 00:00 [received] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 09:28 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - tp-15-08-330 [pii] AID - 10.21037/tp-2026-0407 [doi] PST - ppublish SO - Transl Pediatr. 2026 Aug 31;15(8):330. doi: 10.21037/tp-2026-0407. Epub 2026 Jul 22. PMID- 42724052 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260911 LR - 20260912 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Insulin resistance evaluated by estimated glucose disposal rate and its association with cardiometabolic risk factors among adolescents in Northeast China. PG - 1853266 LID - 10.3389/fnut.2026.1853266 [doi] LID - 1853266 AB - BACKGROUND: Insulin resistance (IR) is a key factor in cardiometabolic diseases, but there are few practical ways to measure it in adolescents. The insulin sensitivity's surrogate measure, the eGDR, has not been well validated in young populations. METHODS: eGDR was determined by the use of waist circumference (WC), HbA1c levels, and hypertension status in this cross-sectional study of Chinese adolescents. Restricted cubic spline models and multivariate logistic regression were utilized to estimate associations between eGDR and cardiometabolic risk factors (CMRFs), such as dyslipidemia, hyperuricemia, and high fasting plasma glucose (FPG). The eGDR's discriminative performance was compared with traditional IR indices, such as HOMA-IR, TyG, AIP, TyG-BMI, and QUIKI. RESULTS: After confounders' adjustment, each SD raise in eGDR was linked with reduced odds of dyslipidemia (OR = 0.781, 95% CI: 0.703-0.866, p < 0.001) and hyperuricemia (OR = 0.884, 95% CI: 0.800-0.977, p = 0.016). eGDR showed negative correlations with atherogenic lipid subfractions, such as LDL-C, non-HDL-C, and triglycerides (TG), but not with total cholesterol (TC) or FPG. Subgroup analyses showed that the protective effect against dyslipidemia was stronger in participants with BMI in the >/= 85th percentile, and sex-specific differences in the associations with TG and FPG. eGDR was found to be better than traditional IR indices in discriminating clustered CMRFs. Sex-specific cut-offs for IR were determined: eGDR <8.06 mg/kg/min and <8.46 mg/kg/min for males and females, respectively. CONCLUSION: eGDR is a strong, non-invasive cardiometabolic risk indicator in adolescents, especially dyslipidemia and hyperuricemia. It can offer a feasible instrument of early risk stratification in this group. CI - Copyright (c) 2026 Wang, Yao, Li and Du. FAU - Wang, Yiwen AU - Wang Y AD - Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Yao, Hui AU - Yao H AD - Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Li, Ling AU - Li L AD - Department of Endocrinology, Jinghua Hospital, Shenyang, China. FAU - Du, Runyu AU - Du R AD - Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China. LA - eng PT - Journal Article DEP - 20260827 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13558436 OTO - NOTNLM OT - adolescents OT - cardiometabolic risk OT - estimated glucose disposal rate OT - insulin resistance OT - predictive performance COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2026/08/27 CRDT- 2026/09/11 08:18 PHST- 2026/04/11 00:00 [received] PHST- 2026/07/25 00:00 [revised] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 08:18 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - 10.3389/fnut.2026.1853266 [doi] PST - epublish SO - Front Nutr. 2026 Aug 27;13:1853266. doi: 10.3389/fnut.2026.1853266. eCollection 2026. PMID- 42723824 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260912 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Distinct metabolic phenotypes in adolescents with obesity identified by unsupervised learning: associations with insulin resistance and resting energy expenditure. PG - 1875870 LID - 10.3389/fendo.2026.1875870 [doi] LID - 1875870 AB - BACKGROUND: Pediatric obesity is characterized by substantial metabolic heterogeneity, including adiposity, insulin resistance, inflammation, and energy metabolism. Traditional categorical classifications may inadequately capture this complexity. Objective: To identify clinically meaningful metabolic phenotypes using unsupervised clustering and to compare the statistical performance and clinical interpretability of two- and three-cluster solutions. METHODS: In this cross-sectional study, 758 children and adolescents with obesity underwent anthropometric, biochemical, and indirect calorimetry assessments. Fat-free mass was estimated using validated bioimpedance-based equations, and fat-free mass index (FFMI) was standardized before clustering. K-means clustering (k = 2 and k = 3) was performed using FFMI z-score, BMI-SDS, HOMA-IR, triglycerides, and HDL-cholesterol. Cluster validity was assessed using the Silhouette, Elbow, Davies-Bouldin index, Calinski-Harabasz index, and Gap statistic methods. Validation employed variables not included in clustering, such as glucose-insulin dynamics, inflammatory and hepatic markers, blood pressure, respiratory quotient, and resting energy expenditure (REE). Group comparisons were performed using Kruskal-Wallis and Dunn's post-hoc tests with false discovery rate correction. RESULTS: Both clustering solutions demonstrated significant separation across metabolic domains. The two-cluster model identified metabolically favourable and unfavourable phenotypes differing in adiposity, insulin resistance, inflammatory burden, hepatic markers, blood pressure, and REE. The three-cluster solution revealed a more granular metabolic stratification with an intermediate phenotype characterized by partial metabolic impairment. Validation confirmed robust differences across physiological variables (all FDR-adjusted p < 0.05). Although the two-cluster solution showed slightly superior internal validity, the three-cluster model provided greater clinical granularity and phenotypic resolution. CONCLUSIONS: Unsupervised clustering identified biologically coherent metabolic phenotypes in pediatric obesity. While the two-cluster solution provided statistically robust stratification, the three-cluster configuration captured a broader spectrum of metabolic heterogeneity and risk profiles, supporting the application of higher-resolution phenotyping approaches in pediatric endocrinology and metabolic risk assessment. CI - Copyright (c) 2026 Sonza, Tamini, Bondesan, Caroli, Abbruzzese and Sartorio. FAU - Sonza, Anelise AU - Sonza A AD - Centro de Ciencias da Saude e do Esporte (CEFID), Department of Physical Therapy, Programa de Pos-Graduacao em Ciencias do Movimento Humano (PPGCMH), Universidade do Estado de Santa Catarina (UDESC), Florianopolis, Brazil. AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Piancavallo-Verbania, Italy. FAU - Tamini, Sofia AU - Tamini S AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Piancavallo-Verbania, Italy. FAU - Bondesan, Adele AU - Bondesan A AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Piancavallo-Verbania, Italy. FAU - Caroli, Diana AU - Caroli D AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Piancavallo-Verbania, Italy. FAU - Abbruzzese, Laura AU - Abbruzzese L AD - Division of Auxology, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Piancavallo-Verbania, Italy. FAU - Sartorio, Alessandro AU - Sartorio A AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Piancavallo-Verbania, Italy. AD - Division of Auxology, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Piancavallo-Verbania, Italy. LA - eng PT - Journal Article DEP - 20260827 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - *Insulin Resistance/physiology MH - Female MH - Cross-Sectional Studies MH - Adolescent MH - Phenotype MH - *Energy Metabolism/physiology MH - Male MH - *Pediatric Obesity/metabolism MH - Child MH - *Unsupervised Machine Learning MH - Clustering Algorithms MH - Cluster Analysis MH - Body Mass Index PMC - PMC13557994 OTO - NOTNLM OT - clustering analysis OT - energy metabolism OT - insulin resistance OT - metabolic phenotyping OT - obesity OT - pediatric endocrinology COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2026/08/27 CRDT- 2026/09/11 06:04 PHST- 2026/05/08 00:00 [received] PHST- 2026/08/04 00:00 [revised] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 06:04 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - 10.3389/fendo.2026.1875870 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Aug 27;17:1875870. doi: 10.3389/fendo.2026.1875870. eCollection 2026. PMID- 42723572 OWN - NLM STAT- Publisher LR - 20260911 IS - 2769-707X (Electronic) IS - 2769-7061 (Linking) DP - 2026 Sep 11 TI - Dietary Patterns and Acne Severity in Middle Eastern Youth: The Negative Correlation Role of Fermented Dairy Products. PG - 1-11 LID - 10.1080/27697061.2026.2725655 [doi] AB - OBJECTIVE: Acne vulgaris is one of the most prevalent skin disorders worldwide, affecting 85-90% of teenagers. Acne can be caused by a variety of factors, but lifestyle decisions like stress levels, sleep patterns, and diet can play a significant part. This research aims to examine how lifestyle factors impact the severity of acne vulgaris. METHODS: Patients with acne who visited dermatology clinics at a primary referral hospital in northern Jordan were included. They also used the validated Global Acne Severity Scale to assess acne severity. Structured interviews gathered information on dietary habits, physical activity, sleep quality, smoking behaviors, and psychological stress. The study identified risk factors associated with moderate-to-severe acne through multivariate logistic regression analysis. RESULTS: The study included 423 participants with a mean age of 20.2 years. Frequent consumption of fast food (adjusted odds ratio [aOR] = 1.56, 95% confidence interval [CI]: 1.21-1.81) and sweets (aOR = 1.51, 95% CI: 1.15-1.98); lack of sleep (aOR = 1.19, 95% CI:1.02-1.36); and high psychological stress (aOR = 1.63, 95% CI: 1.28-1.93) were all significant correlates of moderate-to-severe acne. Regular consumption of fruits and vegetables (aOR = 0.66, 95% CI:0.41-0.84) and regular exercise (aOR = 0.76, 95% CI: 0.44-0.89) were inversely associated with acne severity. In the exploratory post hoc dairy-subtype analysis, yogurt (aOR = 0.65, 95% CI: 0.53-0.83) and labneh (aOR = 0.63, 95% CI: 0.51-0.79) were inversely associated with moderate-to-severe acne, whereas non-fermented milk was positively associated (aOR = 1.37, 95% CI: 1.12-1.68). CONCLUSION: This clinic-based cross-sectional study identified several demographic and lifestyle factors associated with acne severity among Jordanian youth. The exploratory post hoc analysis also identified inverse associations between yogurt and labneh consumption and moderate-to-severe acne, while non-fermented milk showed a positive association. These findings are hypothesis-generating and require confirmation in prospective and interventional studies before specific dietary or lifestyle recommendations can be established. FAU - Seetan, Khaled AU - Seetan K AD - Faculty of Medicine, Yarmouk University, Irbid, Jordan. FAU - Khamees, Almu'atasim AU - Khamees A AUID- ORCID: 0000-0002-6282-8351 AD - Faculty of Medicine, Yarmouk University, Irbid, Jordan. AD - Princess Basma Teaching Hospital, Ministry of Health, Irbid, Jordan. FAU - Yassin, Raghad Yousef AU - Yassin RY AUID- ORCID: 0000-0003-0435-4124 AD - Faculty of Pharmacy, Yarmouk University, Irbid, Jordan. FAU - Mahmoud Hamad, Amro Mousa AU - Mahmoud Hamad AM AUID- ORCID: 0009-0002-4967-6223 AD - King Hussein Cancer Center, Amman, Jordan. FAU - Kiwan, Bashar Moh'd AU - Kiwan BM AD - Faculty of Medicine, Yarmouk University, Irbid, Jordan. FAU - Kasasbeh, Dana Mohammad AU - Kasasbeh DM AD - Faculty of Medicine, Yarmouk University, Irbid, Jordan. FAU - Ayesh, Monther Ahmad AU - Ayesh MA AD - Faculty of Medicine, Yarmouk University, Irbid, Jordan. FAU - Abedalaziz, Irjuwan Muhye Aldeen AU - Abedalaziz IMA AD - Faculty of Medicine, Yarmouk University, Irbid, Jordan. FAU - Almajali, Hamza Samah AU - Almajali HS AD - Faculty of Medicine, Yarmouk University, Irbid, Jordan. FAU - Al Sarhan, Bashar Salem AU - Al Sarhan BS AD - Faculty of Medicine, Yarmouk University, Irbid, Jordan. LA - eng PT - Journal Article DEP - 20260911 PL - United States TA - J Am Nutr Assoc JT - Journal of the American Nutrition Association JID - 9918300687506676 SB - IM OAB - Several dietary and lifestyle factors were associated with acne severity in this Jordanian clinic-based population. Frequent consumption of sweets, fast food, and non-fermented milk was associated with greater acne severity, whereas yogurt and labneh were inversely associated with moderate-to-severe acne in an exploratory post hoc analysis. These observational findings are hypothesis-generating and require confirmation in prospective and interventional studies before specific dietary or lifestyle recommendations can be made. OABL- eng OTO - NOTNLM OT - Acne vulgaris OT - acne severity OT - diet OT - lifestyle OT - stress EDAT- 2026/09/11 05:36 MHDA- 2026/09/11 05:36 CRDT- 2026/09/11 04:33 PHST- 2026/09/11 05:36 [medline] PHST- 2026/09/11 05:36 [pubmed] PHST- 2026/09/11 04:33 [entrez] AID - 10.1080/27697061.2026.2725655 [doi] PST - aheadofprint SO - J Am Nutr Assoc. 2026 Sep 11:1-11. doi: 10.1080/27697061.2026.2725655. PMID- 42723365 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260913 IS - 2162-3279 (Electronic) VI - 16 IP - 9 DP - 2026 Sep TI - Association Between Dietary Regimens and Eating Disorder Susceptibility Among Adults in Riyadh, Saudi Arabia. PG - e71688 LID - 10.1002/brb3.71688 [doi] LID - e71688 AB - OBJECTIVE: To systematically examine the association between dietary practices and eating disorder susceptibility among adults in Riyadh, Saudi Arabia, and to determine whether specific dieting characteristics are associated with elevated eating disorder symptoms. METHOD: A cross-sectional study was conducted among Saudi adults aged 18-45 years residing in Riyadh between December 2024 and August 2025. Participants were recruited through online platforms using convenience sampling. Eating disorder susceptibility was assessed using the validated Eating Attitudes Test (EAT-26), with a score >/= 20 indicating elevated susceptibility. Dietary behaviors during the previous 6 months were self-reported and categorized into index-based, macronutrient-focused, pattern/lifestyle, and special or plant-based diets. Multivariable logistic regression models and general linear models were used to examine associations between dietary variables and eating disorder susceptibility and symptom severity. RESULTS: Among the 188 participants included in the primary analysis, 90 (47.9%) participants were susceptible to eating disorders. Participants who had followed any dietary regimen in the previous 6 months were significantly more likely to exhibit eating disorder susceptibility compared with non-dieters (p < 0.001). DISCUSSION: These findings suggest that recent engagement in dieting, rather than specific dietary characteristics, is associated with increased eating disorder susceptibility among adults in Riyadh. Public health efforts should emphasize balanced, evidence-based dietary guidance and increased awareness of the potential psychological risks of unsupervised dieting. Longitudinal research is needed to clarify temporal relationships and causal pathways. CI - (c) 2026 The Author(s). Brain and Behavior published by Wiley Periodicals LLC. FAU - Aldahash, Rehab A AU - Aldahash RA AUID- ORCID: 0000-0003-2703-3585 AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Alturki, Haifa Y AU - Alturki HY AUID- ORCID: 0009-0000-6048-8528 AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Alonazi, Shahad G AU - Alonazi SG AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Dabbour, Joury AU - Dabbour J AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Aldossari, Shahad M AU - Aldossari SM AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Aldhfayan, Sara AU - Aldhfayan S AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. LA - eng GR - PNURSP2026R533/Princess Nourah bint Abdulrahman University Researchers Supporting Project/ GR - PNURSP2026R533/Princess Nourah Bint Abdulrahman University/ PT - Journal Article PL - United States TA - Brain Behav JT - Brain and behavior JID - 101570837 SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Adult MH - *Feeding and Eating Disorders/epidemiology MH - Female MH - Cross-Sectional Studies MH - Male MH - Young Adult MH - Adolescent MH - *Diet MH - Middle Aged MH - *Feeding Behavior/physiology MH - Disease Susceptibility PMC - PMC13563051 OTO - NOTNLM OT - Eating Attitudes Test (EAT-26) OT - Saudi Arabia OT - dietary patterns OT - dieting behavior OT - eating disorder susceptibility COIS- The authors declare no conflicts of interest. EDAT- 2026/09/11 05:36 MHDA- 2026/09/11 05:37 PMCR- 2026/09/10 CRDT- 2026/09/11 02:43 PHST- 2026/07/27 00:00 [revised] PHST- 2026/01/21 00:00 [received] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/09/11 05:37 [medline] PHST- 2026/09/11 05:36 [pubmed] PHST- 2026/09/11 02:43 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - BRB371688 [pii] AID - 10.1002/brb3.71688 [doi] PST - ppublish SO - Brain Behav. 2026 Sep;16(9):e71688. doi: 10.1002/brb3.71688. PMID- 42722725 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260917 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Sep 8 TI - Probability of predicting dietary pattern adherence among primary schoolchildren based on socio-demographic data, anthropometric parameters, physical activity levels, and nutritional knowledge. LID - 10.1038/s41598-026-70753-6 [doi] LID - 28356 AB - Adolescence is a critical period of rapid physical and psychosocial development during which eating behaviours are influenced by a variety of internal and external factors. Understanding these relationships is crucial for preventing unhealthy dietary habits and for effective nutrition education. This cross-sectional study included 7,763 schoolchildren aged 10-12 (49.2% boys, 50.8% girls) from Polish schools. The validated questionnaire was used to assess children's nutritional knowledge, dietary habits, and physical activity. Standard anthropometric measurements (body weight, height, waist circumference) were taken, and BMI, WHtR, RFMp, and TMI were calculated. Descriptive statistics were used for sample characteristics. Principal component analysis (PCA) with varimax rotation (MSA = 0.796) was used to identify dietary patterns. Logistic regression modeled predictors of belonging to the highest tertile. Three dietary patterns were identified: Salty-Sweet, Plant-Dairy, and Protein. Children classified as overweight according to the RFMp index and children who were very physically active showed less adherence to the Salty-Sweet Pattern. Schoolchildren who were underweight according to the BMI index and those with low nutritional knowledge were more likely to follow the Salty-Sweet Pattern. Girls, children with an elevated waist-to-hip ratio (WHtR), and very physically active children were more likely to be in the third tertile of the Plant-Dairy Pattern. Schoolchildren with low nutritional knowledge showed less adherence to this pattern. Girls showed less adherence to the protein pattern, whereas underweight children and those who were very physically active showed greater adherence. The dietary patterns of schoolchildren are interrelated, and knowledge of nutrition and physical activity is the main modifiable determinant. These factors can be utilised when developing strategies for regularly assessing nutritional status and providing specialist advice to schoolchildrens, their families, and teachers. CI - (c) 2026. The Author(s). FAU - Drywien, Malgorzata Ewa AU - Drywien ME AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences SGGW, Warsaw, Poland. FAU - Czarniecka-Skubina, Ewa AU - Czarniecka-Skubina E AD - Department of Food Gastronomy and Food Hygiene, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences SGGW, Nowoursynowska st. 159c, Warsaw, 02-787, Poland. ewa_czarniecka-skubina@sggw.edu.pl. FAU - Hamulka, Jadwiga AU - Hamulka J AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences SGGW, Warsaw, Poland. FAU - Gebski, Jerzy AU - Gebski J AD - Department of Food Market and Consumer Research, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences SGGW, Warsaw, Poland. FAU - Januszko, Olga AU - Januszko O AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences SGGW, Warsaw, Poland. FAU - Sadowska, Joanna AU - Sadowska J AD - Department of Applied Microbiology and Human Nutrition Physiology, West Pomeranian University of Technology in Szczecin, Szczecin, Poland. FAU - Gutkowska, Krystyna AU - Gutkowska K AD - Department of Food Market and Consumer Research, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences SGGW, Warsaw, Poland. LA - eng GR - MEiN/2022/DPI/96 of 7 March 2022/Polish Ministry of Education and Science/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260908 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Child MH - *Exercise MH - Male MH - *Feeding Behavior MH - Anthropometry MH - Cross-Sectional Studies MH - *Health Knowledge, Attitudes, Practice MH - Body Mass Index MH - Poland MH - *Diet MH - Surveys and Questionnaires PMC - PMC13562532 OTO - NOTNLM OT - Anthropometric data OT - Dietary patterns OT - Nutritional knowledge OT - Physical activity OT - Schoolchildren OT - Socio-demographic factors COIS- Declarations. Competing interests: Ewa Czarniecka-Skubina - Editor Board Member. Implications and contribution: This study has implications for educational and public health policies targeting young people. Adolescents follow distinct dietary patterns shaped by modifiable factors. These findings may inform strategies to prevent nutritional deficiencies through regular dietary assessment and targeted guidance for schoolchildrenadolescents, families, and educators. EDAT- 2026/09/11 05:36 MHDA- 2026/09/11 05:37 PMCR- 2026/09/08 CRDT- 2026/09/10 23:46 PHST- 2026/07/03 00:00 [received] PHST- 2026/09/04 00:00 [accepted] PHST- 2026/09/11 05:37 [medline] PHST- 2026/09/11 05:36 [pubmed] PHST- 2026/09/10 23:46 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - 10.1038/s41598-026-70753-6 [pii] AID - 70753 [pii] AID - 10.1038/s41598-026-70753-6 [doi] PST - epublish SO - Sci Rep. 2026 Sep 8;16(1):28356. doi: 10.1038/s41598-026-70753-6. PMID- 42721609 OWN - NLM STAT- Publisher LR - 20260910 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 153 DP - 2026 Aug 18 TI - Not only bowel: opportunistic assessment of sarcopenia in pediatric ulcerative colitis patients undergoing magnetic resonance enterography. PG - 113402 LID - S0899-9007(26)00309-6 [pii] LID - 10.1016/j.nut.2026.113402 [doi] AB - PURPOSE: Malnutrition and sarcopenia are under-recognized complications in pediatric inflammatory bowel disease, with an understudied interrelationship. This exploratory study aimed to estimate the prevalence of sarcopenia in children with newly diagnosed Ulcerative Colitis (UC) and to investigate associations between opportunistically MRE-derived muscle metrics and clinical, laboratory, and endoscopic disease activity. MATERIALS AND METHODS: Retrospective enrollment of 20 children aged 6-18 years who were ultimately diagnosed with UC and had undergone MRE as part of the systematic initial diagnostic work-up for suspected pediatric IBD. Total psoas muscle area (tPMA) was measured on axial T2-weighted images at the L3 vertebral level and used as a sarcopenia biomarker: "at risk of sarcopenia" with tPMA <10th percentile, and with "severe sarcopenia" /=0.70, 0.80, and 0.90). Sensitivity analyses using the combined durations of sessions and glances produced similar conservative monitoring-day recommendations. RESULTS: Single-day ICCs were 0.69 (95% CI 0.63-0.76) for Android Chronicle and 0.71 (95% CI 0.65-0.77) for iOS Screenshot data. Point-estimate projections indicated that 2 monitoring days were sufficient to achieve an ICC>/=0.80 for both data sources. Using the more conservative criterion that the lower bound of the projected 95% CI exceeded 0.80, 3 monitoring days were required for both Android and iOS data. Screen time was significantly lower on weekends than on weekdays, suggesting that monitoring periods should include at least 1 weekend day. CONCLUSIONS: Among caregivers of preschool-aged children, relatively short objective monitoring periods may provide reliable estimates of average daily smartphone screen time within a 7-day monitoring period. Two monitoring days were sufficient under point-estimate projections, whereas 3 days were required using a conservative lower-bound criterion. These findings support the feasibility of brief smartphone monitoring protocols for estimating the 7-day average duration, while emphasizing the importance of including weekend representation and avoiding the extension of these estimates to longer-term habitual smartphone behavior or screen time metrics beyond duration without further evidence. CI - (c) Joshua Culverhouse, Taylor Adair, Meghan Restino, Heidi M Weeks, Jenny S Radesky, R Glenn Weaver, Sarah Burkart, Hannah Parker, Olivia L Finnegan, Anthony J Holmes, Keagan Kiely, Rahul Ghosal, Srihari Nelakuditi, Michael W Beets, Bridget Armstrong. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org). FAU - Culverhouse, Joshua AU - Culverhouse J AUID- ORCID: 0000-0001-5345-5760 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Adair, Taylor AU - Adair T AUID- ORCID: 0009-0008-8045-9984 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Restino, Meghan AU - Restino M AUID- ORCID: 0009-0004-1557-2471 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Weeks, Heidi M AU - Weeks HM AUID- ORCID: 0000-0003-3467-7987 AD - University of Michigan School of Public Health, Ann Arbor, MI, United States. FAU - Radesky, Jenny S AU - Radesky JS AUID- ORCID: 0000-0002-7721-7350 AD - University of Michigan Medical School, Ann Arbor, MI, United States. FAU - Weaver, R Glenn AU - Weaver RG AUID- ORCID: 0000-0001-5889-974X AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Burkart, Sarah AU - Burkart S AUID- ORCID: 0000-0002-0840-1680 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Parker, Hannah AU - Parker H AUID- ORCID: 0000-0003-4197-7224 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Finnegan, Olivia L AU - Finnegan OL AUID- ORCID: 0000-0003-0625-1479 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Holmes, Anthony J AU - Holmes AJ AUID- ORCID: 0000-0003-4711-629X AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Kiely, Keagan AU - Kiely K AUID- ORCID: 0009-0008-0015-3484 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Ghosal, Rahul AU - Ghosal R AUID- ORCID: 0000-0003-0939-4731 AD - Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, United States. FAU - Nelakuditi, Srihari AU - Nelakuditi S AUID- ORCID: 0000-0001-5990-394X AD - Department of Computer Science and Engineering, University of South Carolina, Columbia, SC, United States. FAU - Beets, Michael W AU - Beets MW AUID- ORCID: 0000-0001-6728-6742 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Armstrong, Bridget AU - Armstrong B AUID- ORCID: 0000-0002-1909-8170 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. LA - eng GR - P20 GM130420/GM/NIGMS NIH HHS/United States GR - R01 HD112311/HD/NICHD NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260910 PL - Canada TA - JMIR Mhealth Uhealth JT - JMIR mHealth and uHealth JID - 101624439 SB - IM MH - Humans MH - *Smartphone/statistics & numerical data/instrumentation/standards MH - Reproducibility of Results MH - *Caregivers/statistics & numerical data/psychology MH - Child, Preschool MH - *Screen Time MH - Female MH - Male MH - Time Factors PMC - PMC13561401 OTO - NOTNLM OT - passive sensing OT - reliability OT - sampling duration OT - screen time OT - smartphone COIS- Conflicts of Interest: The authors declare no conflicts of interest. EDAT- 2026/09/10 17:42 MHDA- 2026/09/10 17:43 PMCR- 2026/09/10 CRDT- 2026/09/10 15:53 PHST- 2025/08/22 00:00 [received] PHST- 2026/07/17 00:00 [revised] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/09/10 17:43 [medline] PHST- 2026/09/10 17:42 [pubmed] PHST- 2026/09/10 15:53 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - v14i1e82846 [pii] AID - 82846 [pii] AID - 10.2196/82846 [doi] PST - epublish SO - JMIR Mhealth Uhealth. 2026 Sep 10;14:e82846. doi: 10.2196/82846. PMID- 42721394 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260910 LR - 20260910 IS - 2757-6256 (Print) IS - 2757-6256 (Linking) VI - 61 IP - 9 DP - 2026 Jul 6 TI - Does Body Fat Mass Influence the Timing of Puberty in Boys with Constitutional Delay of Growth and Puberty? PG - 815-821 LID - 10.65717/TurkArchPediatr.2026.25450 [doi] AB - OBJECTIVE: In girls, a strong relationship exists between body fat percentage (BFP) and pubertal development, with a critical fat threshold considered essential for the initiation of puberty. In contrast, research addressing the impact of body composition on the timing of puberty in boys remains limited, and the available findings are inconsistent. To evaluate the association between body composition and delayed pubertal development in boys with constitutional delay of growth and puberty (CDGP) compared with healthy peers. METHODS: Thirty-one boys with CDGP and 31 age-matched healthy males (Tanner stage 2-4) were included. Body composition was assessed using bioelectrical impedance analysis. Body fat percentage (BFP), fat mass (FM), fat-free mass (FFM), fat mass index (FMI), and fat-free mass index (FFMI) were evaluated. A BFP value of 17% was used as a descriptive reference rather than a validated biological cut-off. RESULTS: The mean chronological age was 14.1 +/- 0.5 years in the CDGP group and 13.9 +/- 1.1 years in the control group (P = .4). Compared with controls, boys with CDGP had significantly lower body mass index (BMI) standard deviation (SD) scores (P = .01). FM and FM SD scores were also significantly lower (both P = .002), and BFP was reduced (P = .03). No significant difference in BFP SD score was observed between groups (P > .05). The FFM/FM ratio was higher in the CDGP group (P = .04). FMI, FMI SD score, FFMI, and FFMI SD score were all significantly lower in boys with CDGP (P = .02, P = .02, P = .009, and P = .009, respectively). A BFP below 17% was observed in 58.1% of CDGP patients compared with 9.7% of controls (P < .001). CONCLUSION: Lower BMI, FM, and FFMI were associated with delayed pubertal onset in boys with CDGP, suggesting a potential relationship between reduced adiposity, lean mass, and the timing of pubertal development. CI - Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. Copyright (c) Author(s) - Available online at https://turkarchpediatr.org/EN. Published by the Turkish Pediatrics Association. FAU - Kagizmanli, Gozde Akin AU - Kagizmanli GA AUID- ORCID: 0000-0002-6158-9002 AD - Department of Pediatric Endocrinology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkiye. FAU - Demir, Korcan AU - Demir K AUID- ORCID: 0000-0002-8334-2422 AD - Department of Pediatric Endocrinology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkiye. FAU - Bober, Ece AU - Bober E AUID- ORCID: 0000-0001-8828-0892 AD - Department of Pediatric Endocrinology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkiye. FAU - Abaci, Ayhan AU - Abaci A AUID- ORCID: 0000-0002-1812-0321 AD - Department of Pediatric Endocrinology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkiye. LA - eng PT - Journal Article DEP - 20260706 PL - Turkey TA - Turk Arch Pediatr JT - Turkish archives of pediatrics JID - 101776822 OTO - NOTNLM OT - Adiposity OT - body composition OT - delayed puberty OT - fat mass OT - male OT - pubertal onset COIS- The authors have no conflicts of interest to declare. EDAT- 2026/09/10 17:42 MHDA- 2026/09/10 17:43 CRDT- 2026/09/10 15:53 PHST- 2026/09/10 17:43 [medline] PHST- 2026/09/10 17:42 [pubmed] PHST- 2026/09/10 15:53 [entrez] AID - 10.65717/TurkArchPediatr.2026.25450 [doi] PST - epublish SO - Turk Arch Pediatr. 2026 Jul 6;61(9):815-821. doi: 10.65717/TurkArchPediatr.2026.25450. PMID- 42717323 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20260916 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Aug 14 TI - Psychometric properties of the Turkish version of the Preschool Eating, Lifestyle, and Sleeping Attitudes (PRELSA) scale. LID - 10.1186/s12887-026-07532-9 [doi] LID - 847 AB - BACKGROUND: Childhood obesity in preschool years is strongly influenced by modifiable parental attitudes and behaviors. This study examined the validity and reliability of the Turkish version of the Preschool Eating, Lifestyle, and Sleeping Attitudes (PRELSA) Scale, which assesses parental attitudes related to childhood obesity during the preschool period. METHODS: This methodological study was conducted with 460 parents of children aged 2-6 years from seven preschools in Central Anatolia, Turkiye. Data were collected using a family and child information form and the PRELSA Scale. The adaptation process included forward-backward translation, expert review, face validity assessment, and psychometric evaluation. Data were analyzed using exploratory and confirmatory factor analyses, Cronbach's alpha, test-retest reliability, and intraclass correlation coefficients (ICC). RESULTS: The Turkish version comprised 39 items across 13 subscales. The overall Cronbach's alpha coefficient was 0.887. Exploratory factor analysis explained 58.5% of the total variance, with factor loadings ranging from 0.353 to 0.890. Confirmatory factor analysis indicated acceptable model fit (chi(2)/df = 1.434, RMSEA = 0.031, SRMR = 0.046, CFI = 0.904, IFI = 0.907, GFI = 0.911, TLI = 0.888). Test-retest reliability was high (r = 0.911), and the ICC was 0.865 (95% CI: 0.738-0.933), indicating good temporal stability. CONCLUSION: The Turkish PRELSA Scale is a valid and reliable instrument for assessing parental attitudes toward eating behaviors, physical activity, screen use, and sleep routines in early childhood. CI - (c) 2026. The Author(s). FAU - Bolacali, Edanur Tar AU - Bolacali ET AUID- ORCID: 0000-0001-8821-8554 AD - Faculty of Health Sciences, Department of Children Health and Disease Nursing, Kirsehir Ahi Evran University, Kirsehir, Turkiye. edanur.tar@ahievran.edu.tr. FAU - Bolacali, Memis AU - Bolacali M AUID- ORCID: 0000-0002-4196-2359 AD - Faculty of Medicine, Department of Biostatistics and Medical Informatics, Kirsehir Ahi Evran University, Kirsehir, Turkiye. LA - eng PT - Journal Article PT - Validation Study DEP - 20260814 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Child, Preschool MH - Turkey MH - Male MH - Psychometrics MH - Female MH - Reproducibility of Results MH - Child MH - *Parents/psychology MH - *Life Style MH - *Sleep MH - Surveys and Questionnaires MH - *Pediatric Obesity/psychology/prevention & control MH - Factor Analysis, Statistical MH - *Feeding Behavior/psychology MH - *Attitude to Health PMC - PMC13560222 OTO - NOTNLM OT - Childhood obesity OT - Parents OT - Preschool child OT - Psychometrics OT - Validation study COIS- Declarations. Ethics approval and consent to participate: Written permission for the Turkish adaptation and use of the PRELSA Scale was obtained via email from corresponding author Carretero-Bravo on September 12, 2024. Before starting the study, ethical committee approval was obtained from the Scientific Research and Publication Ethics Committee of Kirsehir Ahi Evran University Faculty of Social and Human Sciences on February 26, 2025, with the number 2025/04/18. In addition, institutional permission for data collection was obtained from the Kirsehir Provincial Directorate of National Education on February 26, 2025, with the number MEB.TT.2025.019400. Prior to data collection, eligible parents were provided with detailed information about the study, and written informed consent was obtained from those who agreed to participate. They were also advised that participation was voluntary and that they could withdraw from the study at any time without consequence. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/10 05:36 MHDA- 2026/09/10 05:37 PMCR- 2026/08/14 CRDT- 2026/09/10 04:40 PHST- 2026/03/09 00:00 [received] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/09/10 05:37 [medline] PHST- 2026/09/10 05:36 [pubmed] PHST- 2026/09/10 04:40 [entrez] PHST- 2026/08/14 00:00 [pmc-release] AID - 10.1186/s12887-026-07532-9 [pii] AID - 7532 [pii] AID - 10.1186/s12887-026-07532-9 [doi] PST - epublish SO - BMC Pediatr. 2026 Aug 14;26(1):847. doi: 10.1186/s12887-026-07532-9. PMID- 42714719 OWN - NLM STAT- MEDLINE DCOM- 20261022 LR - 20261026 IS - 1179-1896 (Electronic) IS - 1175-5652 (Print) IS - 1175-5652 (Linking) VI - 24 IP - 6 DP - 2026 Nov TI - A Scoping Review of the Literature on Child and/or Adolescent Health Microsimulation Models. PG - 1039-1052 LID - 10.1007/s40258-026-01066-y [doi] AB - BACKGROUND: Microsimulation models can be used for diverse purposes such as forecasting and undertaking economic evaluations. A review of the literature of existing child and/or adolescent microsimulation models has yet to be undertaken. The aim of this scoping review was to retrieve, synthesise and critically appraise the literature of child and/or adolescent health microsimulation models. METHODS: A scoping review was conducted using PubMed, Embase, CINAHL, PsyclNFO, EconLit and Scopus. Additional searches (snowballing, Google searches, searches of specific journals and websites) were also undertaken to complement database searches. Relevant data on microsimulation models were extracted, and the quality of models was assessed using the Quality Assessment Reporting for Microsimulation Models checklist. Evidence was synthesised by scope of model, type of model and health outcome examined. RESULTS: Forty-eight relevant microsimulation models were found. Most (n = 33) were developed specifically for children and/or adolescents, but there were a few (n = 15) broader models that examined these populations. Many microsimulation models were developed for the USA (n = 14); several were focused on select health conditions, such as obesity/overweight, cancer and human immunodeficiency virus (HIV). Just over half (n = 27) of the models found were classified as medium quality models, while the remaining ones were deemed high quality (n = 21). Nonetheless, several models lacked validation and, to a lesser extent, uncertainty analyses and generalisability. CONCLUSIONS: There are a substantial number of child and/or adolescent health microsimulation models. However, future research should focus on developing models on other prevalent child/adolescent health conditions (e.g. allergies, ADHD) and for low- and middle-income settings. CI - (c) 2026. The Author(s). FAU - de Oliveira, Claire AU - de Oliveira C AUID- ORCID: 0000-0003-3961-6008 AD - Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada. claire.deoliveira@camh.ca. AD - Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, ON, Canada. claire.deoliveira@camh.ca. AD - Institute for Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. claire.deoliveira@camh.ca. AD - ICES, Toronto, ON, Canada. claire.deoliveira@camh.ca. AD - Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. claire.deoliveira@camh.ca. FAU - Wen, Yingkun Justin AU - Wen YJ AD - Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. FAU - Mengesha, Michael Endale AU - Mengesha ME AUID- ORCID: 0009-0007-7704-9602 AD - Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. FAU - Sampaio, Filipa AU - Sampaio F AUID- ORCID: 0000-0002-5540-9853 AD - Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. AD - Department of Learning, Informatics, Management and Ethics, Karolinska Institute, Stockholm, Sweden. LA - eng PT - Journal Article PT - Review PT - Scoping Review DEP - 20260909 PL - New Zealand TA - Appl Health Econ Health Policy JT - Applied health economics and health policy JID - 101150314 SB - IM MH - Humans MH - Adolescent MH - Child MH - *Adolescent Health MH - *Child Health PMC - PMC13687262 COIS- Declarations. Conflict of interest: The authors do not report any competing interest in accordance with the International Committee of Medical Journal Editors' requirements. Ethics Approval: Not applicable. Consent to Participate: Not applicable. Consent for Publication (from patients/participants): Not applicable. Availability of Data and Material: Not applicable. Code Availability: Not applicable. Authors' Contributions: Claire de Oliveira and Filipa Sampaio conceived and designed the study. Yingkun Justin Wen and Rebecca Wiechers screened the articles in Rayan; Yingkun Justin Wen and Michael Mengesha extracted the data and undertook quality assessment. Claire de Oliveira drafted the original draft of the manuscript. All authors provided comments and critical revisions on drafts of the manuscript. EDAT- 2026/09/09 17:47 MHDA- 2026/10/23 03:22 PMCR- 2026/09/09 CRDT- 2026/09/09 11:26 PHST- 2026/03/23 00:00 [received] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/10/23 03:22 [medline] PHST- 2026/09/09 17:47 [pubmed] PHST- 2026/09/09 11:26 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - 10.1007/s40258-026-01066-y [pii] AID - 1066 [pii] AID - 10.1007/s40258-026-01066-y [doi] PST - ppublish SO - Appl Health Econ Health Policy. 2026 Nov;24(6):1039-1052. doi: 10.1007/s40258-026-01066-y. Epub 2026 Sep 9. PMID- 42713915 OWN - NLM STAT- Publisher LR - 20260909 IS - 2044-835X (Electronic) IS - 0261-510X (Linking) DP - 2026 Sep 9 TI - Framework for Rating and Assessing Media for Early childhood (FRAME): A multidimensional coding system for analysing children's media content. LID - 10.1111/bjdp.70066 [doi] AB - Young children spend an increasing amount of time engaging with screens, including television viewing. Although most research has focused on the quantity of children's viewing, growing evidence suggests that the developmental effects of screen media depend on the quality and characteristics of the content. However, there is currently no comprehensive, developmentally informed framework for systematically assessing the features of child-directed media. We developed the Framework for Rating and Assessing Media for Early childhood (FRAME), a multidimensional content analysis framework grounded in developmental literature that measures prosocial, antisocial and aggressive, educational, emotional, cultural, mental state talk and pacing content in children's television shows. The FRAME was applied to older (N = 22) and contemporary (N = 10) television shows watched by preschool-aged (2-5 years) children in Aotearoa New Zealand to characterize their content. Inter-rater reliability across dimensions and coding categories was acceptable to excellent. Convergent validity was demonstrated through correlations with Common Sense Media ratings, while also highlighting the value of a comprehensive and differentiated coding framework beyond existing measures. These findings demonstrate the reliability and validity of the FRAME and its potential to advance research examining how specific features of child-directed media relate to developmental outcomes. CI - (c) 2026 The Author(s). British Journal of Developmental Psychology published by John Wiley & Sons Ltd on behalf of British Psychological Society. FAU - Gath, Megan AU - Gath M AUID- ORCID: 0000-0002-8647-1262 AD - Child Well-being Research Institute, University of Canterbury, Christchurch, New Zealand. FAU - Swit, Cara AU - Swit C AUID- ORCID: 0000-0002-7198-5869 AD - School of Health Sciences, University of Canterbury, Christchurch, New Zealand. FAU - McLean, Mia AU - McLean M AUID- ORCID: 0000-0003-1186-3699 AD - Psychology & Neuroscience, Auckland University of Technology, Auckland, New Zealand. FAU - Wang, Ying AU - Wang Y AUID- ORCID: 0000-0003-0023-2023 AD - School of Social Sciences and Humanities, Auckland University of Technology, Auckland, New Zealand. FAU - Smith, Jen AU - Smith J AUID- ORCID: 0000-0003-4874-6808 AD - School of Leadership and Professional Practice, University of Canterbury, Christchurch, New Zealand. FAU - Turner, Damian AU - Turner D AUID- ORCID: 0009-0001-0323-9856 AD - Psychology & Neuroscience, Auckland University of Technology, Auckland, New Zealand. FAU - Gawn, Jenna AU - Gawn J AUID- ORCID: 0009-0006-4723-3794 AD - Child Well-being Research Institute, University of Canterbury, Christchurch, New Zealand. LA - eng PT - Journal Article DEP - 20260909 PL - England TA - Br J Dev Psychol JT - The British journal of developmental psychology JID - 8308022 SB - IM OTO - NOTNLM OT - coding system OT - content analysis OT - media OT - preschooler OT - screen time OT - television OT - young children EDAT- 2026/09/09 11:38 MHDA- 2026/09/09 11:38 CRDT- 2026/09/09 08:19 PHST- 2025/10/09 00:00 [received] PHST- 2026/07/31 00:00 [accepted] PHST- 2026/09/09 11:38 [medline] PHST- 2026/09/09 11:38 [pubmed] PHST- 2026/09/09 08:19 [entrez] AID - 10.1111/bjdp.70066 [doi] PST - aheadofprint SO - Br J Dev Psychol. 2026 Sep 9. doi: 10.1111/bjdp.70066. PMID- 42713310 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260921 IS - 1303-2968 (Electronic) IS - 1303-2968 (Linking) VI - 25 IP - 3 DP - 2026 Sep TI - Comparative Effects of Training Modalities on Countermovement Jump Performance in Soccer Players: A Systematic Review and Network Meta-Analysis. PG - 701-713 LID - 10.52082/jssm.2026.701 [doi] AB - The aim of this study was to provide a comprehensive comparison of training modalities for countermovement jump (CMJ) performance in soccer players using a network meta-analysis (NMA). PubMed, Web of Science, Embase, EBSCO, and the Cochrane Library were searched up to November 2025. Randomized controlled trials (RCTs) involving healthy soccer players, evaluating structured training interventions against comparator training or control conditions, and reporting CMJ height outcomes were included. A random-effects NMA was performed to estimate mean differences (MDs) with 95% confidence intervals (CIs), and interventions were ranked using P-scores, integrating both direct and indirect evidence. Subgroup analyses were conducted according to age, sex, and competitive level. Twenty-nine RCTs (n = 450) were included. The network showed moderate heterogeneity and no evidence of significant inconsistency. Combined training (CBT) was ranked highest in effect estimates in CMJ performance compared with traditional soccer training (TST) (MD = 4.92, 95% CI: 3.02-6.83, P-score = 0.98), followed by flywheel resistance training (FT) and plyometric training (PT), whereas other interventions did not demonstrate significant improvements. Subgroup analyses indicated that CBT ranked highest in males, youth, and Tier 2 players; PT ranked highest in females and adults; and FT ranked highest in highly trained players. Given the limited sample sizes, limited statistical power, and the fragmented nature of some subgroup comparisons, these findings should be interpreted cautiously. The network showed moderate heterogeneity (I(2) = 32.4%) and no evidence of significant inconsistency. The certainty of evidence was generally low to moderate according to the CINeMA assessment. Directness of evidence was generally high across comparisons, although several key contrasts (e.g., CBT vs FT and FT vs PT) relied partly on indirect evidence within the network. Although the highest-ranked interventions (CBT, FT, and PT) were supported primarily by direct comparisons with TST, several active-active contrasts relied partly on indirect estimates. The reliability of the intervention rankings depends on similarity in participant characteristics, intervention dose, outcome measurement, and control conditions. CI - (c) Journal of Sports Science and Medicine. FAU - Dong, Xusong AU - Dong X AD - School of Strength and Conditioning Training, Beijing Sport University, Beijing, China. FAU - Li, Tao AU - Li T AD - School of Chinese Basketball, Beijing Sport University, Beijing, China. FAU - Xing, Weihuan AU - Xing W AD - School of Strength and Conditioning Training, Beijing Sport University, Beijing, China. FAU - Chen, Zezhao AU - Chen Z AD - School of Strength and Conditioning Training, Beijing Sport University, Beijing, China. LA - eng PT - Comparative Study PT - Journal Article PT - Network Meta-Analysis PT - Systematic Review DEP - 20260901 PL - Turkey TA - J Sports Sci Med JT - Journal of sports science & medicine JID - 101174629 SB - IM MH - Humans MH - *Soccer/physiology MH - *Athletic Performance/physiology MH - *Plyometric Exercise MH - Resistance Training/methods MH - Randomized Controlled Trials as Topic MH - *Physical Conditioning, Human/methods PMC - PMC13552851 OTO - NOTNLM OT - Soccer OT - countermovement jump OT - explosive performance OT - network meta-analysis OT - training modalities EDAT- 2026/09/09 11:38 MHDA- 2026/09/09 11:39 PMCR- 2026/09/01 CRDT- 2026/09/09 07:32 PHST- 2026/04/24 00:00 [received] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/09/09 11:39 [medline] PHST- 2026/09/09 11:38 [pubmed] PHST- 2026/09/09 07:32 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - 10.52082/jssm.2026.701 [doi] PST - epublish SO - J Sports Sci Med. 2026 Sep 1;25(3):701-713. doi: 10.52082/jssm.2026.701. eCollection 2026 Sep. PMID- 42712511 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260909 LR - 20260910 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Developing a prediction model of neonatal pneumonia in patients with gestational diabetes mellitus in primary medical institutions. PG - 1840176 LID - 10.3389/fped.2026.1840176 [doi] LID - 1840176 AB - BACKGROUND: The incidence of gestational diabetes mellitus (GDM) continues to rise in China, and the risk of neonatal pneumonia is significantly increased, but the primary medical institutions lack simple and effective early risk assessment methods. OBJECTIVE: To construct a prediction model for neonatal pneumonia suitable for primary medical institutions, based on readily available clinical characteristics of pregnant women with GDM, we aimed to identify key risk factors and provide a basis for developing clinical intervention strategies. METHODS: Data on pregnant women and their newborns at Anyue Maternal and Child Health Hospital from 2023 to 2025 were retrospectively collected. Eight machine learning methods were used to construct the prediction model by bootstrap method and SHapley Additive exPlanations (SHAP) was used to enhance the model's interpretability. RESULTS: A total of 328 pairs of mothers and newborns were included, and the incidence of neonatal pneumonia was 8.8%. Among the eight prediction models, Random Forest model performed the best and Decision tree model was the worst; SHAP results indicated education level, BMI, hyperemesis gravidarum, primipara, hyperlipidemia during pregnancy, premature birth and job were most influencing factors. Binary logistic regression analysis showed that premature birth (OR = 4.763, 95% CI = 1.522-14.901, P = 0.007), Hyperemesis Gravidarum (OR = 3.706, 95% CI = 1.587-8.653, P = 0.002), and cesarean section (OR = 2.456, 95% CI = 1.050-5.745, P = 0.038) were risk factor of neonatal pneumonia, with a protective factor of higher education level (OR = 0.370, 95% CI = 0.158-0.865, P = 0.022). CONCLUSION: Despite the limited number of neonatal pneumonia events, our findings provide preliminary evidence that it may be feasible to develop a simplified risk-stratification tool for neonatal pneumonia in pregnancies complicated by GDM using routinely available clinical variables. Further multicentre prospective studies are required to determine the optimal predictor set and externally validate the model before clinical application. CI - (c) 2026 Wu, Cao, Wu, Liao, Li and Yang. FAU - Wu, Lian AU - Wu L AD - Department of Pediatrics and Obstetrics, Anyue Maternal and Child Health Hospital, Ziyang, Sichuan, China. FAU - Cao, Qun AU - Cao Q AD - Department of Pediatrics and Obstetrics, Anyue Maternal and Child Health Hospital, Ziyang, Sichuan, China. FAU - Wu, Jing AU - Wu J AD - Department of Pediatrics and Obstetrics, Anyue Maternal and Child Health Hospital, Ziyang, Sichuan, China. FAU - Liao, Ting AU - Liao T AD - Department of Pediatrics and Obstetrics, Anyue Maternal and Child Health Hospital, Ziyang, Sichuan, China. FAU - Li, Li AU - Li L AD - Department of Pediatrics and Obstetrics, Anyue Maternal and Child Health Hospital, Ziyang, Sichuan, China. FAU - Yang, Chengying AU - Yang C AD - Department of Pediatrics and Obstetrics, Anyue Maternal and Child Health Hospital, Ziyang, Sichuan, China. LA - eng PT - Journal Article DEP - 20260825 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13550188 OTO - NOTNLM OT - gestational diabetes mellitus OT - hyperemesis during pregnancy OT - neonatal pneumonia OT - prediction model OT - preterm COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/09 11:38 MHDA- 2026/09/09 11:39 PMCR- 2026/08/25 CRDT- 2026/09/09 06:08 PHST- 2026/03/27 00:00 [received] PHST- 2026/08/12 00:00 [revised] PHST- 2026/08/12 00:00 [accepted] PHST- 2026/09/09 11:39 [medline] PHST- 2026/09/09 11:38 [pubmed] PHST- 2026/09/09 06:08 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - 10.3389/fped.2026.1840176 [doi] PST - epublish SO - Front Pediatr. 2026 Aug 25;14:1840176. doi: 10.3389/fped.2026.1840176. eCollection 2026. PMID- 42712217 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260914 IS - 1471-2865 (Electronic) IS - 1358-2267 (Print) IS - 1358-2267 (Linking) VI - 31 IP - 4 DP - 2026 Oct TI - Criterion Validity of the 30-Second Chair Stand Test for Lower-Limb Muscle Strength in Adults With Severe Mental Disorders: The PsychiActive Project. PG - e70344 LID - 10.1002/pri.70344 [doi] LID - e70344 AB - BACKGROUND AND PURPOSE: Individuals with Severe Mental Disorders (SMDs) face a high risk of premature mortality and disability due to accelerated neuromuscular decline. Despite the critical need to monitor physical function, the lack of validated, time-efficient tools limits their clinical utility and hinders the integration of objective assessments into routine care. This gap limits the early identification of physical function impairments and the implementation of timely evidence-based interventions. This is the first study to evaluate the criterion validity of the 30-s Chair Stand Test (30s-CST) as a pragmatic indicator of lower-limb muscle strength in adults with SMDs, providing a feasible functional indicator to support routine clinical assessment. METHODS: Using a cross-sectional validation design (STROBE), this study was conducted with 91 adults (18-65 years) diagnosed with SMDs. Participants performed the 30s-CST and reference isometric Knee Extension Strength (KES) testing. Statistical analyses included Pearson's correlation (r), Intraclass Correlation Coefficients (ICC), and Bland-Altman plots to determine agreement and heteroscedasticity, with sub-analyses by sex, age, and body mass index. RESULTS: Analysis revealed significant moderate correlation and agreement (r = 0.56 [95% CI 0.40-0.69]; ICC = 0.54 [0.38-0.67]; both p < 0.001) for the total sample, with stronger results in the female subgroup. The 30s-CST demonstrated precision, with a prediction error lower than the within-subject variability of the reference method. Bland-Altman plots showed acceptable agreement, with narrow limits of agreement (-1.79-1.80), and analysis indicated homoscedasticity. DISCUSSION: The 30s-CST appears to be a pragmatic and time-efficient screening tool for identifying individuals with reduced lower-limb muscle strength in SMDs. Although limited by the lack of biomechanical specificity between dynamic and isometric methods, the test offers a balance between clinical feasibility and its ability to provide a functional estimate related to lower-limb muscle strength. Integrating this pragmatic screening tool into routine practice may support the assessment of functional performance in resource-constrained settings where more complex strength assessments are not readily available. CI - (c) 2026 The Author(s). Physiotherapy Research International published by John Wiley & Sons Ltd. FAU - Lopez-Moral, Alvaro AU - Lopez-Moral A AUID- ORCID: 0000-0003-0862-8655 AD - Physical Performance & Sports Research Center (CIRFD), Department of Sports and Computer Science, Section of Physical Education and Sports, Faculty of Sports Sciences, Universidad Pablo de Olavide, Seville, Spain. AD - Department of Physical Education and Sport, Universidad de Sevilla, Seville, Spain. FAU - Munguia-Izquierdo, Diego AU - Munguia-Izquierdo D AUID- ORCID: 0000-0001-7817-747X AD - Physical Performance & Sports Research Center (CIRFD), Department of Sports and Computer Science, Section of Physical Education and Sports, Faculty of Sports Sciences, Universidad Pablo de Olavide, Seville, Spain. AD - Research Group in Development Movimiento Humano, Universidad de Zaragoza, Zaragoza, Spain. FAU - Bueno-Antequera, Javier AU - Bueno-Antequera J AUID- ORCID: 0000-0001-8063-3980 AD - Physical Performance & Sports Research Center (CIRFD), Department of Sports and Computer Science, Section of Physical Education and Sports, Faculty of Sports Sciences, Universidad Pablo de Olavide, Seville, Spain. AD - Research Group in Development Movimiento Humano, Universidad de Zaragoza, Zaragoza, Spain. LA - eng GR - PID2020-118262RB-I00/Ministerio de Ciencia e Innovacion/ GR - POSTDOC_21_00059/Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades/ GR - PPI1803/Universidad Pablo de Olavide/ PT - Journal Article PT - Validation Study PL - United States TA - Physiother Res Int JT - Physiotherapy research international : the journal for researchers and clinicians in physical therapy JID - 9612022 SB - IM MH - Humans MH - Female MH - *Muscle Strength/physiology MH - Adult MH - Middle Aged MH - Cross-Sectional Studies MH - Male MH - Reproducibility of Results MH - *Lower Extremity/physiopathology MH - *Mental Disorders/physiopathology MH - Aged MH - Young Adult MH - Adolescent PMC - PMC13555177 OTO - NOTNLM OT - chair stand test OT - functional assessment OT - muscle strength OT - physical function OT - physical performance OT - rehabilitation OT - severe mental disorders COIS- The authors declare no conflicts of interest. EDAT- 2026/09/09 11:38 MHDA- 2026/09/09 11:39 PMCR- 2026/09/09 CRDT- 2026/09/09 05:32 PHST- 2026/08/05 00:00 [revised] PHST- 2026/03/04 00:00 [received] PHST- 2026/08/11 00:00 [accepted] PHST- 2026/09/09 11:39 [medline] PHST- 2026/09/09 11:38 [pubmed] PHST- 2026/09/09 05:32 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - PRI70344 [pii] AID - 10.1002/pri.70344 [doi] PST - ppublish SO - Physiother Res Int. 2026 Oct;31(4):e70344. doi: 10.1002/pri.70344. PMID- 42711707 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260921 IS - 1741-7015 (Electronic) IS - 1741-7015 (Linking) VI - 24 IP - 1 DP - 2026 Aug 27 TI - Conflicting evidence for continuous glucose monitoring in gestational diabetes: current challenges and the imperative for individual participant data meta-analysis. LID - 10.1186/s12916-026-05191-2 [doi] LID - 476 AB - BACKGROUND: The incidence of gestational diabetes mellitus (GDM) is rising along with rates of obesity and type 2 diabetes. GDM is associated with an increased risk of various short- and long-term complications for both mother and child, including type 2 diabetes. Managing GDM requires a multidisciplinary approach that includes dietary guidance, promoting regular physical activity, and performing self-monitoring of blood glucose (SMBG). Continuous glucose monitoring (CGM) has transformed pregnancy care in women with type 1 diabetes and is increasingly being proposed as a strategy to improve glycaemic management in GDM. By capturing postprandial glucose excursions, glycaemic variability, and time in range, CGM provides a more detailed picture of glycaemia and has raised expectations of improved metabolic control and pregnancy outcomes. MAIN BODY: Despite these theoretical advantages, evidence for CGM in GDM remains conflicting. More recently, several large randomized controlled trials (RCT's) show conflicting data: some studies show modest improvements in glycaemic measures, whereas others report no clear benefit for key maternal or neonatal outcomes, leaving the clinical value and cost-effectiveness of CGM unclear. A major limitation is the absence of validated CGM-based glycaemic targets specific to GDM, and current guidelines offer little direction beyond conventional SMBG guidelines. Future research should prioritize adequately powered large RCT's representing a broad population, and, importantly, individual participant data meta-analyses to reconcile inconsistent findings, identify subgroups most likely to benefit, establish pregnancy-specific CGM thresholds, and evaluate the impact on both obstetric outcomes and long-term postpartum metabolic risk. CONCLUSIONS: This ongoing debate underscores the need to critically appraise the role of CGM in GDM, summarize results from completed RCT's and meta-analyses, recognize key methodological and clinical evidence gaps, and outline the steps required for CGM to become fully integrated into standard GDM care. CI - (c) 2026. The Author(s). FAU - Geerts, Ina AU - Geerts I AD - Clinical and Experimental Endocrinology, KU Leuven, 3000, Leuven, Belgium. FAU - Yu, Catherine AU - Yu C AD - Clinical and Experimental Endocrinology, KU Leuven, 3000, Leuven, Belgium. FAU - Embo, Nina AU - Embo N AD - Clinical and Experimental Endocrinology, KU Leuven, 3000, Leuven, Belgium. FAU - Benhalima, Katrien AU - Benhalima K AUID- ORCID: 0000-0002-3325-0263 AD - Clinical and Experimental Endocrinology, KU Leuven, 3000, Leuven, Belgium. katrien.benhalima@uzleuven.be. AD - Department of Endocrinology, University Hospitals Leuven, 3000, Leuven, Belgium. katrien.benhalima@uzleuven.be. LA - eng PT - Journal Article PT - Review DEP - 20260827 PL - England TA - BMC Med JT - BMC medicine JID - 101190723 RN - 0 (Blood Glucose) SB - IM MH - Female MH - Humans MH - Pregnancy MH - *Blood Glucose/analysis MH - *Blood Glucose Self-Monitoring/methods MH - *Continuous Glucose Monitoring MH - *Diabetes, Gestational/blood/diagnosis/therapy MH - Meta-Analysis as Topic PMC - PMC13556021 OTO - NOTNLM OT - Continuous glucose monitoring OT - Gestational diabetes mellitus OT - Individual participant data meta-analysis OT - Pregnancy OT - Technology COIS- Declarations. Ethics approval and consent to participate: not applicable. Consent for publication: not applicable. AI statement: Microsoft Copilot was used solely for language editing to improve the clarity and readability of the manuscript. The authors reviewed and edited all AI-assisted text and take full responsibility for the content of the manuscript. Competing interests: I.G. is the recipient of a PhD fellowship, strategic basic research (FWO-SB) from the Flemish Research Council (FWO) 1S82826N. KB received a senior clinical fellowship from FWO Flanders (1800220 N). KB received an unrestricted grant and study devices from Medtronic for the investigator-initiated CRISTAL study. KB received study devices from Dexcom for the investigator-initiated GLORIA study. KB received study medication from Novo Nordisk A/S for the investigator-initiated SERENA study. KB received study devices from Abbott and LifeScan, and a grant from Abbott for the investigator-initiated CORDELIA study. KB received a speaker's fee from Novo Nordisk, AstraZeneca, and Medtronic. KB was a Guest Editor for the Diagnosis and Management of Gestational Diabetes collection (special issue on gestational diabetes). All other authors declared no competing interests. EDAT- 2026/09/09 07:07 MHDA- 2026/09/09 11:38 PMCR- 2026/08/27 CRDT- 2026/09/09 04:50 PHST- 2026/05/26 00:00 [received] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/09/09 11:38 [medline] PHST- 2026/09/09 07:07 [pubmed] PHST- 2026/09/09 04:50 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - 10.1186/s12916-026-05191-2 [pii] AID - 5191 [pii] AID - 10.1186/s12916-026-05191-2 [doi] PST - epublish SO - BMC Med. 2026 Aug 27;24(1):476. doi: 10.1186/s12916-026-05191-2. PMID- 42711563 OWN - NLM STAT- Publisher LR - 20260909 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Sep 8 TI - Comparing two diagnostic frameworks for obesity in Mexican children attending a pediatric obesity clinic. LID - 10.1038/s41390-026-05479-2 [doi] AB - BACKGROUND: Body mass index (BMI) is widely used to assess pediatric obesity but does not fully capture adiposity-related organ dysfunction. The Clinical Framework of Obesity 2025 (CFO-2025), proposed by The Lancet Diabetes & Endocrinology Commission, offers a complementary clinical approach. OBJECTIVE: To evaluate pediatric obesity classification using Centers for Disease Control and Prevention BMI (CDC-BMI) criteria and the CFO-2025, and to describe organ-system involvement in clinical obesity. METHODS: This cross-sectional study analyzed 220 patients aged 4-16 years from a pediatric obesity clinic in northeastern Mexico. Obesity was classified using CDC-BMI criteria and the CFO-2025 with pediatric adaptations. Under the CFO-2025, patients were categorized as having preclinical or clinical obesity based on organ-system involvement. Concordance was assessed using Cohen's kappa. RESULTS: Obesity prevalence was 80% by CDC-BMI criteria and 95% by the CFO-2025, with fair concordance (kappa = 0.321; p < 0.001). Clinical obesity was identified in 83.2% of patients, including those classified as having normal weight or overweight by CDC-BMI; metabolic (73.2%) and cardiovascular (59%) systems were most frequently affected. CONCLUSIONS: Applied alongside BMI, the CFO-2025 identified additional multisystem involvement. Although not yet validated in children, it may support a more comprehensive clinical assessment of pediatric obesity. IMPACT: In the Pediatric Obesity Clinic at a referral hospital in northeastern Mexico, the Clinical Framework of Obesity 2025 (CFO-2025) classified a higher proportion of children as having obesity compared with the CDC-BMI criteria, with only fair concordance between systems. We provide preliminary pediatric evidence that the CFO-2025 identifies multisystem involvement, including metabolic and cardiovascular abnormalities, even among children categorized as normal weight or overweight by BMI. Although the CFO-2025 has not yet been validated in pediatric populations, integrating BMI with the CFO-2025 may support a more structured and comprehensive assessment of obesity-related organ involvement in children. CI - (c) 2026. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - Guzman-Garcia, Judith E AU - Guzman-Garcia JE AD - Pediatric Obesity Clinic, Hospital Regional Materno Infantil, Guadalupe, Mexico. drajudithguzman@gmail.com. AD - Tecnologico de Monterrey, School of Medicine and Health Sciences, Monterrey, Mexico. drajudithguzman@gmail.com. FAU - Gomez-Orozco, Patricio AU - Gomez-Orozco P AD - Pediatric Obesity Clinic, Hospital Regional Materno Infantil, Guadalupe, Mexico. AD - Universidad Autonoma de Nuevo Leon, School of Medicine, Monterrey, Mexico. FAU - Velasco-Rodriguez, Victor Manuel AU - Velasco-Rodriguez VM AD - Universidad Autonoma de Coahuila, Faculty of Nursing, Laguna Unit, Torreon, Mexico. FAU - Martinez-Tapia, Maria Elena AU - Martinez-Tapia ME AD - Tecnologico de Monterrey, School of Medicine and Health Sciences, Monterrey, Mexico. FAU - Rodriguez-Gutierrez, Nora A AU - Rodriguez-Gutierrez NA AUID- ORCID: 0009-0003-0302-7145 AD - Pediatric Obesity Clinic, Hospital Regional Materno Infantil, Guadalupe, Mexico. AD - Tecnologico de Monterrey, School of Medicine and Health Sciences, Monterrey, Mexico. LA - eng PT - Journal Article DEP - 20260908 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Consent statement: The requirement for individual informed consent was waived by the Ethics Committee of the Hospital Regional Materno Infantil and the Department of Education, Health Research, and Quality of the Ministry of Health of Nuevo Leon due to the retrospective design of the study and the use of de-identified data. EDAT- 2026/09/09 07:07 MHDA- 2026/09/09 07:07 CRDT- 2026/09/09 04:27 PHST- 2026/02/24 00:00 [received] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/06/26 00:00 [revised] PHST- 2026/09/09 07:07 [medline] PHST- 2026/09/09 07:07 [pubmed] PHST- 2026/09/09 04:27 [entrez] AID - 10.1038/s41390-026-05479-2 [pii] AID - 10.1038/s41390-026-05479-2 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Sep 8. doi: 10.1038/s41390-026-05479-2. PMID- 42711187 OWN - NLM STAT- Publisher LR - 20260913 IS - 2352-7226 (Electronic) IS - 2352-7218 (Print) IS - 2352-7218 (Linking) DP - 2026 Sep 8 TI - Data-driven derivation of a multidimensional sleep health framework in adolescents. LID - S2352-7218(26)00192-0 [pii] LID - 10.1016/j.sleh.2026.08.011 [doi] AB - OBJECTIVES: Multidimensional sleep health captures the 24-hour experience of sleep as regularity, satisfaction, alertness, timing, efficiency, and duration. However, most evidence comes from adults. Adolescents have unique sleep needs that may not be fully represented. This study aimed to empirically identify and validate dimensions of adolescent sleep health and evaluate methods relevant to their assessment. METHODS: We analyzed subjective and objective sleep measures from 347 adolescents in the Penn State Child Cohort (16.3+/-2.2 years; 45.8% female; 22.2% race and ethnic minority). Exploratory factor analysis was conducted in a random 40% subsample to identify latent dimensions of self-reported, actigraphy, and polysomnography measures, followed by confirmatory factor analysis in the remaining 60% to test model validity. RESULTS: Exploratory factor analysis identified 6 dimensions: Breathing, Efficiency, Duration, Regularity/variability, Satisfaction, and Timing, collectively referred to as the BEDReST framework, explaining 63% of the variance. Confirmatory factor analysis of individual factors within the 6-factor structure demonstrated good to excellent fit (Comparative Fit Index = 0.95-1.00; Tucker-Lewis Index = 0.86-1.00; Root Mean Square Error of Approximation = 0.06-0.15; Standardized Root Mean Square Residual < 0.08). All dimensions, except Satisfaction, included objective measures. CONCLUSIONS: We empirically derived and validated 6 dimensions of adolescent sleep health, the BEDReST framework, using a multimethod approach. This approach highlighted the importance of including objective sleep data to comprehensively capture adolescent sleep health. The BEDReST framework extends existing models by incorporating sleep-disordered breathing and provides a foundation for refining the conceptualization and measurement of sleep health during adolescence. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Nyhuis, Casandra C AU - Nyhuis CC AD - Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA; Sleep Research & Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA. FAU - Ballester-Navarro, Pura AU - Ballester-Navarro P AD - Department of Pharmacy, Universidad Catolica San Antonio de Murcia, Murcia, Spain. FAU - Calhoun, Susan L AU - Calhoun SL AD - Sleep Research & Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA. FAU - Liao, Jason AU - Liao J AD - Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA. FAU - Vgontzas, Alexandros N AU - Vgontzas AN AD - Sleep Research & Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA. FAU - Bixler, Edward O AU - Bixler EO AD - Sleep Research & Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA. FAU - Liao, Duanping AU - Liao D AD - Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA. FAU - Wallace, Meredith L AU - Wallace ML AD - Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Fernandez-Mendoza, Julio AU - Fernandez-Mendoza J AD - Sleep Research & Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA. Electronic address: jfmendoza@psu.edu. LA - eng GR - R01 HL136587/HL/NHLBI NIH HHS/United States GR - TL1 TR002016/TR/NCATS NIH HHS/United States GR - R01 HL063772/HL/NHLBI NIH HHS/United States GR - R01 HL097165/HL/NHLBI NIH HHS/United States GR - UL1 TR002014/TR/NCATS NIH HHS/United States PT - Journal Article DEP - 20260908 PL - United States TA - Sleep Health JT - Sleep health JID - 101656808 SB - IM PMC - PMC13555523 MID - NIHMS2206448 OTO - NOTNLM OT - Actigraphy OT - Adolescence OT - Factor analysis OT - Multidimensional sleep health OT - Polysomnography OT - Subjective COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this manuscript. Given their role as Sleep Health Associate Editor, Julio Fernandez-Mendoza, and Statistical Senior Associate Editor, Meredith Wallace, these authors were not involved in the peer review of this article and have no access to information regarding its peer-review. Full responsibility for the editorial process for this article was delegated to another journal editor. Additionally, the authors wish to disclose that Drs. Calhoun, Liao, Vgontzas, Bixler, Liao, and Fernandez-Mendoza report NIH grants during the conduct of this study. EDAT- 2026/09/08 23:35 MHDA- 2026/09/08 23:35 PMCR- 2026/09/09 CRDT- 2026/09/08 21:53 PHST- 2025/10/11 00:00 [received] PHST- 2026/08/05 00:00 [revised] PHST- 2026/08/15 00:00 [accepted] PHST- 2026/09/08 23:35 [medline] PHST- 2026/09/08 23:35 [pubmed] PHST- 2026/09/08 21:53 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - S2352-7218(26)00192-0 [pii] AID - 10.1016/j.sleh.2026.08.011 [doi] PST - aheadofprint SO - Sleep Health. 2026 Sep 8:S2352-7218(26)00192-0. doi: 10.1016/j.sleh.2026.08.011. PMID- 42710441 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261013 IS - 1879-1379 (Electronic) IS - 0022-3956 (Linking) VI - 203 DP - 2026 Dec TI - The interplay between interoceptive sensibility and mindfulness in eating behaviors and psychological distress: A person-centered study in a French community sample. PG - 51-59 LID - S0022-3956(26)00427-9 [pii] LID - 10.1016/j.jpsychires.2026.09.001 [doi] AB - This study examined interoception and mindfulness as related processes in eating behaviors in a non-clinical population. The aim was to identify interoceptive sensibility and mindfulness clusters using a person-centered approach and to examine their associations with eating behaviors, eating disorder risk, body mass index, and psychological distress. An online survey was conducted in a French community sample of 381 adults. Participants completed validated self-report measures assessing interoceptive sensibility, mindfulness, eating behaviors, and psychological distress. Cluster analysis identified four distinct groups reflecting different combinations of interoceptive sensibility and mindfulness. Profiles characterized by higher mindfulness consistently showed more adaptive eating patterns, including lower emotional and external eating and greater reliance on internal cues, regardless of interoceptive levels. In contrast, clusters with lower mindfulness showed higher levels of emotional eating and psychological distress. Within these low mindfulness profiles, high interoception was associated with lower depressive symptoms, lower eating disorder risk, and normal-weight status. These findings suggest that mindfulness was consistently associated with adaptive eating and psychological outcomes across profiles, whereas interoceptive sensibility further differentiated outcomes among profiles characterized by lower mindfulness. Overall, the results highlight the importance of considering both interoceptive sensibility and mindfulness jointly to better understand variability in eating behaviors and psychological distress. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Marinelli, L AU - Marinelli L AD - Univ. Bordeaux LabPsy, UR 4139, Bordeaux, F-33000, France; University Hospital Center of Bordeaux, Haut Leveque Hospital, Eating Disorders Unit, Pessac, 33600, France. Electronic address: lea.marinelli@u-bordeaux.fr. FAU - Berthoz, S AU - Berthoz S AD - Univ. Bordeaux, INCIA CNRS 5287, Bordeaux, 33000, France; Department of Psychiatry for Adolescents & Young Adults, Institut Medico-chirurgical (IMM), Paris, 75014, France. Electronic address: sylvie.berthoz-landron@inserm.fr. FAU - Decamps, G AU - Decamps G AD - Univ. Bordeaux LabPsy, UR 4139, Bordeaux, F-33000, France. Electronic address: greg.decamps@u-bordeaux.fr. FAU - Bourdier, L AU - Bourdier L AD - University Hospital Center of Bordeaux, Haut Leveque Hospital, Eating Disorders Unit, Pessac, 33600, France. Electronic address: lena.bourdier@chu-bordeaux.fr. FAU - Fatseas, M AU - Fatseas M AD - University Hospital Center of Bordeaux, Haut Leveque Hospital, Eating Disorders Unit, Pessac, 33600, France; Univ. Bordeaux, INCIA CNRS 5287, Bordeaux, 33000, France; CH Charles Perrens, Bordeaux, 33000, France. Electronic address: melina.fatseas@u-bordeaux.fr. FAU - Dantzer, C AU - Dantzer C AD - Univ. Bordeaux LabPsy, UR 4139, Bordeaux, F-33000, France. Electronic address: cecile.dantzer@u-bordeaux.fr. LA - eng PT - Journal Article DEP - 20260903 PL - England TA - J Psychiatr Res JT - Journal of psychiatric research JID - 0376331 SB - IM MH - Humans MH - Female MH - *Mindfulness MH - Male MH - Adult MH - *Feeding Behavior/psychology/physiology MH - *Interoception/physiology MH - France MH - Young Adult MH - *Psychological Distress MH - Middle Aged MH - Feeding and Eating Disorders/psychology MH - Cluster Analysis MH - Adolescent MH - *Stress, Psychological/psychology/physiopathology MH - Body Mass Index MH - Emotional Eating OTO - NOTNLM OT - Cluster analysis OT - Eating behavior OT - Interoceptive sensibility OT - Intuitive eating OT - Mindfulness COIS- Declaration of competing interest None. EDAT- 2026/09/08 23:35 MHDA- 2026/10/13 23:35 CRDT- 2026/09/08 18:16 PHST- 2025/02/03 00:00 [received] PHST- 2026/06/08 00:00 [revised] PHST- 2026/09/02 00:00 [accepted] PHST- 2026/10/13 23:35 [medline] PHST- 2026/09/08 23:35 [pubmed] PHST- 2026/09/08 18:16 [entrez] AID - S0022-3956(26)00427-9 [pii] AID - 10.1016/j.jpsychires.2026.09.001 [doi] PST - ppublish SO - J Psychiatr Res. 2026 Dec;203:51-59. doi: 10.1016/j.jpsychires.2026.09.001. Epub 2026 Sep 3. PMID- 42710439 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261013 IS - 1879-1379 (Electronic) IS - 0022-3956 (Linking) VI - 203 DP - 2026 Dec TI - Treating sleep problems in children with Prader-Willi syndrome. PG - 33-40 LID - S0022-3956(26)00422-X [pii] LID - 10.1016/j.jpsychires.2026.08.025 [doi] AB - The purpose of the present study was to investigate the effects of a sleep treatment package on the frequency of night awakenings, bedtime resistance, and caregiver stress with the caregivers of three child participants diagnosed with Prader-Willi syndrome (PWS) using a multiple baseline across subjects design. During baseline, child participants were not exposed to any procedure. During intervention, caregivers implemented a treatment package including graduated extinction, bedtime routines, and bedtime fading without response cost. All interventions were previously successful with children diagnosed with autism spectrum disorder but had not been attempted with this population. Correct responding was defined as zero instances of night awakenings, zero instances of bedtime resistance (different for each child participant) and decreases in caregiver-reported stress. In addition, social validity was assessed using a Likert-style questionnaire. The results show that the treatment package had varying success across all participants, with the most success being for reducing behaviors at bedtime. These results will provide further understanding of the effect behavior-analytic approaches can have on children diagnosed with Prader-Willi syndrome, increasing the number of applications of applied behavior analysis and the supports available for caregivers of children diagnosed with PWS. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Weavers, Aliana AU - Weavers A AD - Brock University, 1812 Sir Isaac Brock Way, St. Catharines, Canada. Electronic address: aweavers@brocku.ca. FAU - Kruse, Laura AU - Kruse L AD - The Chicago School, United States of America. LA - eng PT - Journal Article DEP - 20260904 PL - England TA - J Psychiatr Res JT - Journal of psychiatric research JID - 0376331 SB - IM MH - Humans MH - *Prader-Willi Syndrome/complications MH - *Sleep Wake Disorders/etiology/therapy MH - Child MH - Male MH - Female MH - Caregivers/psychology MH - *Behavior Therapy/methods MH - Surveys and Questionnaires MH - Treatment Outcome OTO - NOTNLM OT - Applied behaviour analysis OT - Children OT - Prader-willi syndrome OT - Sleep COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/08 23:35 MHDA- 2026/10/13 23:35 CRDT- 2026/09/08 18:16 PHST- 2026/02/06 00:00 [received] PHST- 2026/08/07 00:00 [revised] PHST- 2026/08/27 00:00 [accepted] PHST- 2026/10/13 23:35 [medline] PHST- 2026/09/08 23:35 [pubmed] PHST- 2026/09/08 18:16 [entrez] AID - S0022-3956(26)00422-X [pii] AID - 10.1016/j.jpsychires.2026.08.025 [doi] PST - ppublish SO - J Psychiatr Res. 2026 Dec;203:33-40. doi: 10.1016/j.jpsychires.2026.08.025. Epub 2026 Sep 4. PMID- 42709217 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20261025 IS - 1436-6215 (Electronic) IS - 1436-6207 (Print) IS - 1436-6207 (Linking) VI - 65 IP - 7 DP - 2026 Sep 8 TI - Association of the maternal fish and PUFA intake with the risk of hypertensive disorders of pregnancy: a nationwide birth cohort-The Japan Environment and Children's Study (JECS). LID - 10.1007/s00394-026-04103-7 [doi] LID - 249 AB - PURPOSE: Hypertensive disorders of pregnancy (HDP) are a leading cause of maternal and perinatal morbidity. Although n-3 polyunsaturated fatty acids (PUFAs) in fish may prevent HDP, evidence from Japanese populations, particularly regarding the preconception period, remains limited. To examine associations between fish and PUFA intake before and during pregnancy and the risk of HDP using data from a nationwide Japanese birth cohort. METHODS: This analysis included 86,009 women from the Japan Environment and Children's Study. Dietary fish and n-3/n-6 PUFAs intake was assessed using a validated food-frequency questionnaire administered in early pregnancy (median gestational age, 15.0 weeks [interquartile range (IQR) 12.0-19.0]) to capture intake before pregnancy, and in mid to late pregnancy (median gestational age, 27.0 weeks [IQR 25.0-30.0]). Participants were categorized into quintiles of intake. Logistic regression models were used to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for HDP, early-onset HDP (Eo-HDP < 32 weeks), and late-onset HDP (Lo-HDP >/= 32 weeks). Missing data were addressed with multiple imputation. RESULTS: In the overall population, higher fish intake before pregnancy was associated with reduced risks of Eo-HDP in the Q5 groups, whereas higher fish intake during pregnancy was associated with reduced risks of overall HDP in Q4. In analyses restricted to nulliparous women, higher pre-pregnancy fish intake was associated with a lower risk of Eo-HDP (Q4: aOR 0.57; 95% CI 0.34-0.97; p for trend = 0.02), and higher fish intake during pregnancy was associated with a lower risk of Lo-HDP (Q4: aOR 0.79; 95% CI 0.64-0.96). Total n-3 PUFA intake showed significant associations with HDP only in some analyses. Sensitivity analyses using a 34-week cutoff yielded consistent results. CONCLUSION: Fish intake before pregnancy was associated with lower risk of Eo-HDP, whereas intake during pregnancy was linked to reduced risk of Lo-HDP. Sustained fish consumption from preconception through pregnancy may help prevent HDP and inform global nutritional guidance, including preconception care. TRIAL REGISTRATION: The Japan Environment and Children's Study, https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000035091 (Registration no. UMIN000030786). CI - (c) 2026. The Author(s). FAU - Inouye, Takuya AU - Inouye T AUID- ORCID: 0009-0008-9827-6887 AD - Department of Obstetrics and Gynecology, Gunma University Graduate School of Medicine, Gunma, Japan. AD - Toyama Regional Center for JECS, University of Toyama, Toyama, Japan. FAU - Higeta, Daisuke AU - Higeta D AUID- ORCID: 0000-0002-6981-9722 AD - Department of Obstetrics and Gynecology, Gunma University Graduate School of Medicine, Gunma, Japan. FAU - Hamazaki, Kei AU - Hamazaki K AUID- ORCID: 0000-0003-0456-6805 AD - Department of Public Health Faculty of Medicine, Gunma University Graduate School of Medicine, Showa 3 Maebashi, Gunma, Japan. kei.hamazaki@gunma-u.ac.jp. AD - Department of Public Health, Faculty of Medicine, University of Toyama, Toyama, Japan. kei.hamazaki@gunma-u.ac.jp. AD - Toyama Regional Center for JECS, University of Toyama, Toyama, Japan. kei.hamazaki@gunma-u.ac.jp. FAU - Iwase, Akira AU - Iwase A AUID- ORCID: 0000-0002-0031-884X AD - Department of Obstetrics and Gynecology, Gunma University Graduate School of Medicine, Gunma, Japan. FAU - Tsuchida, Akiko AU - Tsuchida A AUID- ORCID: 0000-0003-1209-3104 AD - Department of Public Health, Faculty of Medicine, University of Toyama, Toyama, Japan. AD - Toyama Regional Center for JECS, University of Toyama, Toyama, Japan. FAU - Inadera, Hidekuni AU - Inadera H AUID- ORCID: 0000-0002-3548-221X AD - Department of Public Health, Faculty of Medicine, University of Toyama, Toyama, Japan. AD - Toyama Regional Center for JECS, University of Toyama, Toyama, Japan. FAU - Yoshioka, Eiji AU - Yoshioka E AUID- ORCID: 0000-0003-3316-1057 AD - Department of Public Health, Faculty of Medicine, University of Toyama, Toyama, Japan. AD - Toyama Regional Center for JECS, University of Toyama, Toyama, Japan. CN - Japan Environment and Children's Study Group LA - eng PT - Journal Article DEP - 20260908 PL - Germany TA - Eur J Nutr JT - European journal of nutrition JID - 100888704 RN - 0 (Fatty Acids, Omega-3) RN - 0 (Fatty Acids, Omega-6) SB - IM MH - Female MH - Humans MH - Pregnancy MH - Japan/epidemiology MH - Animals MH - *Hypertension, Pregnancy-Induced/epidemiology/prevention & control MH - Adult MH - *Seafood MH - *Fishes MH - *Fatty Acids, Omega-3/administration & dosage MH - *Diet/methods MH - Birth Cohort MH - *Fatty Acids, Omega-6/administration & dosage MH - *Maternal Nutritional Physiological Phenomena MH - Risk Factors MH - Odds Ratio MH - Cohort Studies MH - Logistic Models MH - Surveys and Questionnaires MH - Gestational Age PMC - PMC13553602 OTO - NOTNLM OT - Birth cohort OT - Fish OT - Hypertensive disorder of pregnancy OT - Polyunsaturated fatty acids OT - Preconception care COIS- Declarations. Competing interests: KH has received lecture honoraria from Sumitomo Pharma Co., Ltd., Suntory Wellness Ltd., JCR Pharmaceuticals Co., Ltd., Otsuka Pharmaceutical Co., Ltd., Pfizer Japan Inc., and Kensho Pharmaceutical Co., Ltd., for presentations related to n-3 PUFAs. All other authors report no conflicts of interest. Declaration of Generative AI and AI-assisted technologies in the writing process: During the preparation of this manuscript, the authors did not use any generative artificial intelligence or AI-assisted technologies for writing, editing, or content generation. The authors take full responsibility for the integrity and originality of the content.ss EDAT- 2026/09/08 17:36 MHDA- 2026/09/08 17:37 PMCR- 2026/09/08 CRDT- 2026/09/08 11:19 PHST- 2026/05/06 00:00 [received] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/08 17:37 [medline] PHST- 2026/09/08 17:36 [pubmed] PHST- 2026/09/08 11:19 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - 10.1007/s00394-026-04103-7 [pii] AID - 4103 [pii] AID - 10.1007/s00394-026-04103-7 [doi] PST - epublish SO - Eur J Nutr. 2026 Sep 8;65(7):249. doi: 10.1007/s00394-026-04103-7. PMID- 42707981 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260908 LR - 20260909 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Enhancing healthy eating and active environments in early learning settings: findings from the eHealth study. PG - 1873291 LID - 10.3389/fnut.2026.1873291 [doi] LID - 1873291 AB - INTRODUCTION: Early childhood educators are important influencers of children's eating and activity behaviors, making them key targets for interventions aimed at improving nutrition and physical activity practices and fostering healthier childcare environments. OBJECTIVE: To evaluate the impact of the eHealth professional development program in improving early childhood education and care (ECEC) nutrition and physical activity environments, educators' nutrition knowledge, attitudes, and behaviors, and educators' perceptions of program acceptability. METHOD: This study was conducted in licensed ECEC centers in one Canadian province. The study used a two-armed quasi-experimental pre-test/post-test design with intervention and control groups and repeated measures to evaluate a 10-month eHealth program informed by Social Cognitive Theory and the Interconnected Model of Professional Growth Theory. The program aimed to enhance educators' capacity to implement evidence-based nutrition and physical activity practices. Delivered in annual cohorts from 2019 to 2021, it comprised two phases: (1) a 12-week series of online educational modules with accompanying virtual Communities of Practice meetings, and (2) a five-month follow-up period involving monthly implementation-coaching virtual Communities of Practice meetings. Validated questionnaires assessed center-level and educator-level outcomes at baseline, five (midpoint), and 10 months (end-of-program). Semi-structured interviews explored perceptions of program acceptability. RESULTS: Compared with controls, significant improvements in center-level nutrition and physical activity environments (mean change 0.362, p = 0.002, Cohen's d = 0.72), and educator nutrition knowledge, attitudes, and behaviors (mean change 5.467, p = 0.023, Cohen's d = 0.69) were observed at midpoint and maintained at the end-of-program. Qualitative findings indicated high acceptability, with educators describing the program as relevant, feasible, and supportive of integrating practices into daily routines. CONCLUSION: The eHealth professional development program was acceptable and associated with improvements in educators' knowledge and adherence to nutrition and physical activity practice guidelines, with sustained effect over time. Scalable, digitally delivered professional development may offer a promising strategy to support healthier ECEC environments. CI - Copyright (c) 2026 Lafave, Hayek, McConnell and Winkens. FAU - Lafave, Lynne M Z AU - Lafave LMZ AD - CHEERS Lab, Department Health and Physical Education, Mount Royal University, Calgary, AB, Canada. FAU - Hayek, Joyce AU - Hayek J AD - CHEERS Lab, Department Health and Physical Education, Mount Royal University, Calgary, AB, Canada. FAU - McConnell, Ceilidh AU - McConnell C AD - CHEERS Lab, Department Health and Physical Education, Mount Royal University, Calgary, AB, Canada. FAU - Winkens, Bjorn AU - Winkens B AD - Faculty of Health, Medicine and Life Sciences, Care and Public Health Research Institute (CAPHRI), Department of Methodology and Statistics, Maastricht University, Maastricht, Netherlands. LA - eng PT - Journal Article DEP - 20260824 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13548801 OTO - NOTNLM OT - eHealth intervention OT - early childhood education and care OT - interconnected model of professional growth OT - linear mixed models OT - nutrition OT - physical activity OT - professional development OT - social cognitive theory COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/08 12:33 MHDA- 2026/09/08 12:34 PMCR- 2026/08/24 CRDT- 2026/09/08 06:41 PHST- 2026/05/05 00:00 [received] PHST- 2026/07/22 00:00 [revised] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/09/08 12:34 [medline] PHST- 2026/09/08 12:33 [pubmed] PHST- 2026/09/08 06:41 [entrez] PHST- 2026/08/24 00:00 [pmc-release] AID - 10.3389/fnut.2026.1873291 [doi] PST - epublish SO - Front Nutr. 2026 Aug 24;13:1873291. doi: 10.3389/fnut.2026.1873291. eCollection 2026. PMID- 42707971 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260908 LR - 20260909 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Artificial intelligence in child nutrition and eating behavior: from prediction to gastronomic mediation. PG - 1952364 LID - 10.3389/fnut.2026.1952364 [doi] LID - 1952364 AB - Artificial intelligence (AI) is entering child nutrition through dietary assessment, malnutrition forecasting, clinical decision support, meal recommendation, conversational interventions, and food-environment monitoring. The consequences of these applications converge in everyday eating. This Mini Review synthesizes evidence on how AI measures nutritional states and mediates food choice, communication, sensory acceptance, family practice, and digital exposure. The evidence supports two connected functions. As nutritional intelligence, AI converts clinical, dietary, and environmental data into assessments or predictions. As gastronomic mediation, it participates in decisions about what foods are noticed, recommended, prepared, discussed, and accepted. Direct pediatric validation is strongest for bounded assessment and forecasting tasks. Child meal-planning studies and generative-AI evaluations based on standardized adolescent profiles reveal a gap between nutrient optimization, culinary coherence, and nutritional safety. A large adolescent chatbot trial combined scalable delivery with null intention-to-treat effects on diet quality and BMI trajectory. Co-design and behavioral studies further identify familiarity, texture, participation, and caregiver involvement as central design variables. We propose five iterative translational gates: technical validity, nutritional validity, behavioral acceptability, contextual legitimacy, and real-world effectiveness and implementation. Future research should combine age-specific nutritional constraints with sensory and cultural knowledge, evaluate performance across food cultures, preserve professional and caregiver oversight, and test outcomes in homes, schools, clinics, and digital food environments. AI can advance child-focused gastronomy by translating computational outputs into safe, culturally meaningful, and developmentally appropriate eating practices. CI - Copyright (c) 2026 Xing and Wu. FAU - Xing, Lu AU - Xing L AD - School of Preschool Education, Changsha Normal University, Changsha, China. AD - School of Education, Faculty of Social Sciences and Leisure Management, Taylor's University, Subang Jaya, Malaysia. FAU - Wu, Xueqi AU - Wu X AD - Taylor's Culinary Institute, Faculty of Social Sciences and Leisure Management, Taylor's University, Subang Jaya, Malaysia. LA - eng PT - Journal Article PT - Review DEP - 20260824 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13548810 OTO - NOTNLM OT - artificial intelligence OT - child nutrition OT - child-centered design OT - digital food environment OT - eating behavior OT - food culture OT - gastronomy OT - personalized nutrition COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/08 12:33 MHDA- 2026/09/08 12:34 PMCR- 2026/08/24 CRDT- 2026/09/08 06:38 PHST- 2026/07/29 00:00 [received] PHST- 2026/08/10 00:00 [revised] PHST- 2026/08/12 00:00 [accepted] PHST- 2026/09/08 12:34 [medline] PHST- 2026/09/08 12:33 [pubmed] PHST- 2026/09/08 06:38 [entrez] PHST- 2026/08/24 00:00 [pmc-release] AID - 10.3389/fnut.2026.1952364 [doi] PST - epublish SO - Front Nutr. 2026 Aug 24;13:1952364. doi: 10.3389/fnut.2026.1952364. eCollection 2026. PMID- 42707362 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260908 LR - 20260909 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Nutrition education and behavioral interventions in youth team-sport and related development settings: a systematic review of nutrition knowledge, dietary behaviors, hydration, body composition, and performance. PG - 1939289 LID - 10.3389/fnut.2026.1939289 [doi] LID - 1939289 AB - INTRODUCTION: Nutrition knowledge and the ability to translate it into appropriate food and hydration choices are important for health, development, recovery, and performance in young athletes. However, evidence on nutrition interventions in youth team-sport settings remains dispersed across sports, educational formats, and outcome domains. This systematic review aimed to synthesize evidence on nutrition education, hydration education, dietary counseling, digital tools, controlled dietary modification, and multicomponent interventions in child, adolescent, and late-adolescent development settings. METHODS: The review followed PRISMA 2020 guidelines and was registered in PROSPERO (CRD420261441507). PubMed/MEDLINE, Scopus, Web of Science Core Collection, SPORTDiscus/EBSCO, and Cochrane CENTRAL were searched from inception to 3 July 2026. Two reviewers independently screened reports, extracted data, and assessed risk of bias using RoB 2 or ROBINS-I. Because of substantial heterogeneity in interventions and outcomes, findings were synthesized narratively. RESULTS: Database searches identified 419 records. After duplicate removal and screening, 46 full-text reports were assessed, 19 were excluded, and 27 unique studies were included. Soccer/football predominated, with additional evidence from volleyball, basketball, handball, baseball, hockey, American football, and mixed-sport settings. Nutrition and sports nutrition knowledge showed the most consistent favorable changes. Findings for dietary intake, diet quality, body composition, biochemical markers, and performance were mixed. Hydration interventions showed clearer short-term improvements when education was combined with practical cues, improved fluid access, feedback, or individualized prescriptions. DISCUSSION: Nutrition interventions in youth team-sport and related development settings may support knowledge acquisition and selected hydration behaviors, but their effects on dietary behavior and physiological outcomes remain uncertain. Confidence in the evidence is limited by small samples, short follow-up periods, heterogeneous measures, reliance on self-report, incomplete fidelity reporting, and risk-of-bias concerns. Future trials should use validated age-appropriate measures, objective outcomes, longer follow-up, prespecified analyses, and implementation strategies involving athletes, families, coaches, schools, and clubs. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261441507, CRD420261441507. CI - Copyright (c) 2026 Victoria-Montesinos, Garcia-Munoz, Mercader-Ros, Jaraba-Salinero and Figueroa-Morales. FAU - Victoria-Montesinos, Desiree AU - Victoria-Montesinos D AD - Faculty of Pharmacy and Nutrition, UCAM Universidad Catolica de Murcia, Murcia, Spain. FAU - Garcia-Munoz, Ana Maria AU - Garcia-Munoz AM AD - Faculty of Pharmacy and Nutrition, UCAM Universidad Catolica de Murcia, Murcia, Spain. FAU - Mercader-Ros, Maria Teresa AU - Mercader-Ros MT AD - Faculty of Pharmacy and Nutrition, UCAM Universidad Catolica de Murcia, Murcia, Spain. FAU - Jaraba-Salinero, Yasmina AU - Jaraba-Salinero Y AD - Faculty of Pharmacy and Nutrition, UCAM Universidad Catolica de Murcia, Murcia, Spain. FAU - Figueroa-Morales, Fernando AU - Figueroa-Morales F AD - Faculty of Pharmacy and Nutrition, UCAM Universidad Catolica de Murcia, Murcia, Spain. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260824 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13547255 OTO - NOTNLM OT - adolescents OT - body composition OT - children OT - dietary behavior OT - nutrition education OT - nutrition knowledge OT - sport performance OT - sports nutrition COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author DV-M declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/09/08 12:33 MHDA- 2026/09/08 12:34 PMCR- 2026/08/24 CRDT- 2026/09/08 05:37 PHST- 2026/07/16 00:00 [received] PHST- 2026/08/06 00:00 [revised] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/09/08 12:34 [medline] PHST- 2026/09/08 12:33 [pubmed] PHST- 2026/09/08 05:37 [entrez] PHST- 2026/08/24 00:00 [pmc-release] AID - 10.3389/fnut.2026.1939289 [doi] PST - epublish SO - Front Nutr. 2026 Aug 24;13:1939289. doi: 10.3389/fnut.2026.1939289. eCollection 2026. PMID- 42706523 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20260910 IS - 1471-2466 (Electronic) IS - 1471-2466 (Linking) VI - 26 IP - 1 DP - 2026 Sep 7 TI - Moving beyond treatment: pulmonary function, autonomous motivation, and physical activity enjoyment in adults with cystic fibrosis. LID - 10.1186/s12890-026-04661-w [doi] LID - 400 AB - BACKGROUND: Physical activity (PA) and structured exercise are established cornerstones of cystic fibrosis (CF) management. While CFTR modulators have transformed treatment, the psychological factors affecting sustained PA adherence, particularly motivational regulation and PA enjoyment, require further investigation. This study aimed to determine whether percent predicted forced expiratory volume in one second (ppFEV(1)) is independently associated with autonomous motivation and PA enjoyment in adults with CF, after adjusting for CFTR modulator therapy status and sex. METHODS: A cross-sectional study was conducted at a specialised CF centre (N = 200). Participants completed validated questionnaires assessing motivational regulation (Behavioural Regulation Questionnaire-2, BREQ-2) and PA enjoyment (Physical Activity Enjoyment Scale, PACES). Clinical data, including the ppFEV(1), were obtained from medical records. Multivariate general linear models (GLM), partial correlations, and hierarchical regression analyses were utilised. RESULTS: Cross-sectional analyses showed that ppFEV(1) was independently associated with intrinsic motivation (beta = .233, p < .001), the relative autonomy index (RAI) (beta = .203, p = .004) and the PACES total score (beta = .201, p = .004). After CFTR modulator therapy status and sex were accounted for, the additional variance explained by the ppFEV(1) was statistically significant but modest (DeltaR(2) = .054, .041, and .040, respectively). Neither the CFTR modulator therapy status nor sex was significantly associated with the assessed motivational or enjoyment outcomes. CONCLUSIONS: Although ppFEV(1) showed small, independent associations with autonomous motivational regulation and PA enjoyment in adults with CF, lung function should not be used as a proxy for motivational support needs. To provide person-centred, SDT-informed support that encourages sustained participation in PA, the motivational regulation and enjoyment of PA should be assessed directly in adults with CF. CI - (c) 2026. The Author(s). FAU - Gruber, Wolfgang AU - Gruber W AUID- ORCID: 0000-0003-2186-9269 AD - Paediatric Pulmonology and Sleep Medicine, Cystic Fibrosis Centre, Children S Hospital, University of Duisburg-Essen, 45147, Essen, Germany. wolfgang.gruber@uk-essen.de. AD - Fachklinik Satteldune der DRV Nord, Nebel/Amrum, Germany. wolfgang.gruber@uk-essen.de. FAU - Welsner, Matthias AU - Welsner M AD - Department of Pulmonary Medicine, Adult Cystic Fibrosis Center, University Hospital Essen - Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany. FAU - Stehling, Florian AU - Stehling F AD - Paediatric Pulmonology and Sleep Medicine, Cystic Fibrosis Centre, Children S Hospital, University of Duisburg-Essen, 45147, Essen, Germany. FAU - Schermaul, Jin-Sun AU - Schermaul JS AD - Department of Pulmonary Medicine, Adult Cystic Fibrosis Center, University Hospital Essen - Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany. FAU - Ortiz, Jose G AU - Ortiz JG AD - Department of Pulmonary Medicine, Adult Cystic Fibrosis Center, University Hospital Essen - Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany. FAU - Lechtenberg, Liron AU - Lechtenberg L AD - Department of Pulmonary Medicine, Adult Cystic Fibrosis Center, University Hospital Essen - Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany. FAU - Taube, Christian AU - Taube C AD - Department of Pulmonary Medicine, Adult Cystic Fibrosis Center, University Hospital Essen - Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany. FAU - Olivier, Margarete AU - Olivier M AD - Paediatric Pulmonology and Sleep Medicine, Cystic Fibrosis Centre, Children S Hospital, University of Duisburg-Essen, 45147, Essen, Germany. LA - eng PT - Journal Article DEP - 20260907 PL - England TA - BMC Pulm Med JT - BMC pulmonary medicine JID - 100968563 SB - IM MH - Humans MH - *Motivation MH - Male MH - Female MH - Cross-Sectional Studies MH - *Cystic Fibrosis/psychology/physiopathology/therapy MH - Adult MH - Forced Expiratory Volume MH - Surveys and Questionnaires MH - *Exercise/psychology MH - Young Adult MH - Linear Models MH - Adolescent PMC - PMC13548599 OTO - NOTNLM OT - Autonomous motivation OT - CFTR modulator therapy OT - Cystic fibrosis OT - Physical activity enjoyment OT - Pulmonary function OT - Self-determination theory OT - Sex COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki and was approved by the Medical Ethics Committee of the University of Duisburg-Essen (24-11951-BO). Written informed consent was obtained from all participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/08 05:36 MHDA- 2026/09/08 05:37 PMCR- 2026/09/07 CRDT- 2026/09/08 00:06 PHST- 2026/04/13 00:00 [received] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/08 05:37 [medline] PHST- 2026/09/08 05:36 [pubmed] PHST- 2026/09/08 00:06 [entrez] PHST- 2026/09/07 00:00 [pmc-release] AID - 10.1186/s12890-026-04661-w [pii] AID - 4661 [pii] AID - 10.1186/s12890-026-04661-w [doi] PST - epublish SO - BMC Pulm Med. 2026 Sep 7;26(1):400. doi: 10.1186/s12890-026-04661-w. PMID- 42703382 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260908 IS - 1177-8881 (Electronic) IS - 1177-8881 (Linking) VI - 20 DP - 2026 TI - A Physiologically-Based Pharmacokinetic Model to Predict Posaconazole Suspension Exposure and Optimize Dosing Strategy in Pediatric Hematology Patients: Incorporating the Impact of Food Intake. PG - 632843 LID - 10.2147/DDDT.S632843 [doi] LID - 632843 AB - OBJECTIVE: This study aimed to develop and validate a physiologically based pharmacokinetic (PBPK) model for posaconazole oral suspension in pediatric hematology patients to predict systemic exposure and optimize dose regimens that incorporate food intake. METHODS: A PBPK model was established and validated in adults. The model was then extrapolated to pediatric patients by integrating age-specific physiological parameters. The pediatric model was validated using published data and local therapeutic drug monitoring results. The validated model was employed to simulate posaconazole exposure across different age groups, dosing regimens, and meal conditions. RESULTS: The adult PBPK model showed good predictability, with fold errors within 0.5-2.0 and a geometric mean fold error < 2.0. Sensitivity analysis identified the bile salt solubilization ratio, gastric pH, and hepatic UGT1A4 as critical determinants. The pediatric model accurately predicted plasma concentrations, with a mean absolute prediction error of 12.3%. Simulations revealed that achieving prophylactic trough concentration (C(min)) is challenging under fasted conditions, while fed administration significantly increases C(min)s. C(min)s increased with age and meal fat/calorie content, but no significant further increase was observed across all age groups beyond 6 mg/kg dose levels under fed conditions, with this plateau pattern consistent for both three- and four-times daily regimens. The oral suspension was unreliable in children aged < 2 years. In contrast, a high-fat, high-calorie meal was necessary for children aged 2-6 years, and a moderate-fat, moderate-calorie meal for those aged 7-12 years, whereas a low-fat, low-calorie meal was sufficient for those aged >/= 13 years. CONCLUSION: This study successfully developed and validated a PBPK model for posaconazole suspension in pediatric hematology patients, which could serve as a supportive in silico tool for model-informed dose optimization in this population. Further prospective clinical validation is still required to support its real-world dosing decision application. CI - (c) 2026 Wu et al. FAU - Wu, Juan AU - Wu J AUID- ORCID: 0000-0002-0792-5300 AD - Department of Pharmacy Administration, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. FAU - Qin, Xia AU - Qin X AD - Blood and Marrow Transplantation Center, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. FAU - Huang, Xiaohang AU - Huang X AUID- ORCID: 0009-0000-3530-3835 AD - Blood and Marrow Transplantation Center, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. FAU - Wang, Dengyu AU - Wang D AD - Department of Pharmacy Administration, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. FAU - Jin, Cheng AU - Jin C AD - Department of Pharmacy Administration, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. FAU - Huang, Shiying AU - Huang S AD - Department of Pharmacy Administration, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. FAU - Li, Zhuo AU - Li Z AD - Department of Pharmacy Administration, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. FAU - Liu, Manman AU - Liu M AD - Department of Pharmacy Administration, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. LA - eng PT - Journal Article DEP - 20260902 PL - New Zealand TA - Drug Des Devel Ther JT - Drug design, development and therapy JID - 101475745 RN - 0 (Triazoles) RN - 6TK1G07BHZ (posaconazole) RN - 0 (Suspensions) RN - 0 (Antifungal Agents) SB - IM MH - Humans MH - *Triazoles/pharmacokinetics/administration & dosage/blood MH - Child MH - *Models, Biological MH - Suspensions MH - Child, Preschool MH - Administration, Oral MH - Dose-Response Relationship, Drug MH - *Antifungal Agents/pharmacokinetics/administration & dosage MH - Adolescent MH - *Eating MH - Infant MH - Male MH - Female PMC - PMC13546638 OTO - NOTNLM OT - dose optimization OT - food intake OT - pediatrics OT - physiologically based pharmacokinetic model OT - posaconazole oral suspension COIS- The authors have no conflicts of interest to declare regarding the content of this article. EDAT- 2026/09/07 05:35 MHDA- 2026/09/07 05:36 PMCR- 2026/09/02 CRDT- 2026/09/07 04:02 PHST- 2026/06/14 00:00 [received] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/09/07 05:36 [medline] PHST- 2026/09/07 05:35 [pubmed] PHST- 2026/09/07 04:02 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - 632843 [pii] AID - 10.2147/DDDT.S632843 [doi] PST - epublish SO - Drug Des Devel Ther. 2026 Sep 2;20:632843. doi: 10.2147/DDDT.S632843. eCollection 2026. PMID- 42701327 OWN - NLM STAT- Publisher LR - 20260906 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) DP - 2026 Sep 6 TI - Bringing the child's and parents' voices together: French validation of the SMU and STU quality of life questionnaires in pediatric obesity. PG - 2601060261484279 LID - 10.1177/02601060261484279 [doi] AB - BackgroundChildhood obesity is associated with significant impairments in health-related quality of life (HRQoL), yet culturally adapted, weight-specific tools are lacking in French-speaking settings.AimThis study aimed to validate French versions of the Sizing Me Up (SMU) and Sizing Them Up (STU) questionnaires to assess obesity-related quality of life in children and adolescents from self- and parent-report perspectives.MethodsShortened French versions of the SMU and STU were developed, retaining three subscales common to both instruments (Emotional, Physical, and Teasing/Marginalization) based on theoretical and psychometric criteria. A clinical sample included 120 children and adolescents with obesity (aged 5-18 years) and their parents. Psychometric analyses included internal consistency, confirmatory factor analysis, convergent validity with the Pediatric Quality of Life Inventory (PedsQL), sensitivity to body mass index (BMI) z-scores, measurement invariance across age and sex, and parent-child agreement.ResultsBoth instruments demonstrated good internal consistency and a stable three-factor structure. Associations were observed between the BMI z-score and the Physical domain, with modest effect sizes comparable to those of the generic PedsQL. Convergent validity was supported by correlations with corresponding PedsQL subscales. Measurement invariance held across age groups and for the SMU across sex, but the STU across sex did not achieve configural invariance. Procrustean analysis indicated moderate structural similarities between child and parent profiles, with moderate to good individual-level agreement, higher for physical than emotional domains.SummaryThe shortened French SMU and STU are reliable and valid tools for assessing HRQoL in pediatric obesity, supporting their use in clinical and research settings. FAU - Brodard, Fabrice AU - Brodard F AUID- ORCID: 0000-0002-3000-0891 AD - Family and Development Research Center, University of Lausanne, Lausanne, Switzerland. RINGGOLD: 27213 AD - Institute of Psychology, University of Lausanne, Lausanne, Switzerland. RINGGOLD: 27213 FAU - Antonietti, Jean-Philippe AU - Antonietti JP AUID- ORCID: 0000-0003-0117-4769 AD - Family and Development Research Center, University of Lausanne, Lausanne, Switzerland. RINGGOLD: 27213 FAU - Amouroux, Remy AU - Amouroux R AUID- ORCID: 0000-0003-3402-0942 AD - Family and Development Research Center, University of Lausanne, Lausanne, Switzerland. RINGGOLD: 27213 FAU - Bouthors, Therese AU - Bouthors T AD - Unit of Pediatric Endocrinology and Diabetology Unit, Service of Pediatrics, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland. RINGGOLD: 527885 FAU - Hauschild, Michael AU - Hauschild M AD - Unit of Pediatric Endocrinology and Diabetology Unit, Service of Pediatrics, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland. RINGGOLD: 527885 FAU - Ruiz Arana, Inge Lore AU - Ruiz Arana IL AD - Unit of Pediatric Endocrinology and Diabetology Unit, Service of Pediatrics, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland. RINGGOLD: 527885 FAU - Antoniou, Maria-Christina AU - Antoniou MC AUID- ORCID: 0000-0002-8089-7908 AD - Unit of Pediatric Endocrinology and Diabetology Unit, Service of Pediatrics, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland. RINGGOLD: 527885 LA - eng PT - Journal Article DEP - 20260906 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 SB - IM OTO - NOTNLM OT - French translation OT - Pediatric obesity OT - SMU OT - STU OT - quality of life OT - questionnaire validation EDAT- 2026/09/06 05:40 MHDA- 2026/09/06 05:40 CRDT- 2026/09/06 03:23 PHST- 2026/09/06 05:40 [medline] PHST- 2026/09/06 05:40 [pubmed] PHST- 2026/09/06 03:23 [entrez] AID - 10.1177/02601060261484279 [doi] PST - aheadofprint SO - Nutr Health. 2026 Sep 6:2601060261484279. doi: 10.1177/02601060261484279. PMID- 42700485 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261008 IS - 1872-7123 (Electronic) IS - 0165-1781 (Linking) VI - 366 DP - 2026 Dec TI - Agreement between smartphone-based mobile sensing and actigraphy sleep metrics in young people with bipolar disorder. PG - 117434 LID - S0165-1781(26)00494-4 [pii] LID - 10.1016/j.psychres.2026.117434 [doi] AB - BACKGROUND: Sleep disturbance is a core feature of bipolar disorder (BD) and often precedes mood recurrence, particularly in youth. Smartphone-based mobile sensing offers a scalable alternative to objective sleep measurement via actigraphy, but its validity in youths with BD is unclear. METHODS: Analyses included adolescents and young adults (ages 14-25) with BD-I/II from the PROMPT-BD study with at least four days of concurrent actigraphy and mobile sensing. Actigraphy-derived sleep metrics were compared with smartphone-derived proxies. Agreement was evaluated using root mean squared error (RMSE) and mixed-effects models. Zero-inflated negative binomial models examined associations between actigraphy-derived and mobile-sensing derived wake after sleep onset (WASO). Sensitivity analyses tested robustness to missing data, smartphone use patterns, sleep window definitions, operating system, presence of mood symptoms and anxiety, and weekend effects. RESULTS: Mobile sensing showed strong convergence with actigraphy for sleep timing and duration. RMSEs were <21 minutes for onset, offset, midsleep, and TST, with strongest agreement for midsleep (RMSE = 14.8 minutes). Mobile sensing slightly overestimated sleep duration and estimated earlier timing, and underestimated WASO. Greater WASO significantly increased the odds of detecting any via mobile sensing; mobile sensing proxies were sensitive to the presence of nocturnal wakefulness but did not provide an accurate estimate of the extent of sleep fragmentation. Findings were robust across sensitivity analyses. CONCLUSIONS: Passive smartphone-derived sleep metrics approximated actigraphy-based estimates of sleep timing and duration in youth with BD. Given the widespread availability of smartphones in this population, this supports their potential as scalable tools for monitoring circadian disruption and informing early intervention. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Lopaczynski, Adrianna AU - Lopaczynski A AD - University of Pittsburgh Medical Center, Pittsburgh, USA. Electronic address: lopaczynskia2@upmc.edu. FAU - Merranko, John AU - Merranko J AD - University of Pittsburgh Medical Center, Pittsburgh, USA. FAU - Mak, Jessica AU - Mak J AD - University of Pittsburgh Medical Center, Pittsburgh, USA. FAU - Gill, Mary Kay AU - Gill MK AD - University of Pittsburgh Medical Center, Pittsburgh, USA. FAU - Goldstein, Tina R AU - Goldstein TR AD - University of Pittsburgh Medical Center, Pittsburgh, USA; University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, USA. FAU - Fedor, Jennifer AU - Fedor J AD - University of Pittsburgh School of Medicine, Department of Medicine, Pittsburgh, USA. FAU - Low, Carissa AU - Low C AD - University of Pittsburgh School of Medicine, Department of Medicine, Pittsburgh, USA. FAU - Levenson, Jessica C AU - Levenson JC AD - University of Pittsburgh Medical Center, Pittsburgh, USA; University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, USA. FAU - Birmaher, Boris AU - Birmaher B AD - University of Pittsburgh Medical Center, Pittsburgh, USA; University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, USA. FAU - Hafeman, Danella M AU - Hafeman DM AD - University of Pittsburgh Medical Center, Pittsburgh, USA; University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, USA. LA - eng PT - Journal Article DEP - 20260901 PL - Ireland TA - Psychiatry Res JT - Psychiatry research JID - 7911385 SB - IM UOF - medRxiv. 2026 Mar 02:2026.02.20.26346722. doi: 10.64898/2026.02.20.26346722. PMID: 41867203 MH - Humans MH - *Actigraphy/standards/methods MH - *Smartphone MH - *Bipolar Disorder/complications/physiopathology MH - Adolescent MH - Female MH - *Sleep Wake Disorders/diagnosis/etiology/physiopathology MH - Male MH - Young Adult MH - Adult MH - Sleep Duration MH - Sleep/physiology OTO - NOTNLM OT - Actigraphy OT - Adolescence OT - Bipolar disorder OT - Digital phenotyping OT - Mobile sensing OT - Mood recurrence OT - Sleep COIS- Declaration of competing interest The authors declare that they have no conflicts of interest related to this study. EDAT- 2026/09/06 01:18 MHDA- 2026/10/08 23:31 CRDT- 2026/09/05 18:00 PHST- 2026/03/19 00:00 [received] PHST- 2026/08/25 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/08 23:31 [medline] PHST- 2026/09/06 01:18 [pubmed] PHST- 2026/09/05 18:00 [entrez] AID - S0165-1781(26)00494-4 [pii] AID - 10.1016/j.psychres.2026.117434 [doi] PST - ppublish SO - Psychiatry Res. 2026 Dec;366:117434. doi: 10.1016/j.psychres.2026.117434. Epub 2026 Sep 1. PMID- 42699031 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260905 LR - 20260907 IS - 2645-4904 (Electronic) IS - 2645-4904 (Linking) VI - 14 IP - 1 DP - 2026 TI - Shock-Stratified Prognostic Performance of Lactate and Procalcitonin in Pediatric Sepsis In-Hospital Mortality; A Retrospective Cohort Study. PG - e34 LID - 10.22037/aaem.v14i1.3029 [doi] LID - e34 AB - INTRODUCTION: Admission lactate and procalcitonin (PCT) are routinely measured in pediatric sepsis; however, their prognostic performance may vary by clinical phenotype. This study aimed to evaluate the shock-stratified prognostic performance of admission lactate and PCT for predicting in-hospital mortality in children with sepsis. METHODS: In this retrospective cohort study (July 2022 - July 2025), children aged 2 months to 15 years evaluated for suspected sepsis were screened; 193 met eligibility criteria and were included in analyses. Septic shock was recorded at admission, and organ dysfunction was recorded at admission or within the first 24 hours. The Phoenix Sepsis Score was calculated in 143 patients with complete lactate and other required data, whereas the Pediatric Sequential Organ Failure Assessment (pSOFA) score was calculated for all 193 patients using data recorded within the first 24 hours. Admission lactate and PCT were summarized by survival status within shock and non-shock phenotypes. Multivariable logistic regression models adjusted for age and malnutrition assessed biomarker-mortality associations and biomarker x shock interactions. Discrimination was evaluated using shock-stratified receiver operating characteristic (ROC) curves and area under the curve (AUC), with DeLong tests comparing AUCs between phenotypes. RESULTS: Among 193 children, 93 (48.2%) had septic shock, 145 (75.1%) had organ dysfunction, and 79 (40.9%) died in hospital. The median Phoenix Sepsis Score was 2.0 (range, 0--12) among 143 patients, while the median pSOFA score was 4.0 (range: 0--21) among all 193 patients. Mortality was higher in shock than non-shock sepsis (66.7% vs 17.0%; odds ratio (OR): 9.77 (95% confidence interval (CI): 4.96-19.24)) and in those with organ dysfunction (53.1% vs 4.2%; OR = 26.03 (95% CI: 6.09-111.34)). Admission lactate was higher in non-survivors than survivors in both non-shock and shock groups (p<0.05). In adjusted interaction models, each 1 mmol/L increase in lactate (OR = 1.50, 95% CI: 1.11--2.01; p = 0.0075) and each one-unit increase in natural-log--transformed PCT (ln(PCT)) (OR = 1.34, 95% CI: 1.01-1.79; p=0.0458) were associated with mortality in non-shock sepsis. The lactate x shock interaction (OR = 0.76, 95% CI: 0.55--1.05; p = 0.092) and ln(PCT) x shock interaction (OR = 0.74, 95% CI: 0.52--1.07; p = 0.114) were not statistically significant. Shock-stratified ROC curve analysis showed better discrimination in non-shock than shock for lactate (AUC: 0.76 (95% CI: 0.67-0.85) vs 0.62 (95% CI: 0.40-0.83); DeLong p=0.233) and modest discrimination for natural-log-transformed PCT [ln(PCT)] in both phenotypes (AUC: 0.65 (95% CI: 0.55-0.75) vs 0.61 (95% CI: 0.41-0.80); DeLong p=0.695). CONCLUSION: Admission lactate showed moderate discrimination for in-hospital mortality in non-shock sepsis, whereas discrimination was lower in septic shock. PCT showed modest discrimination across phenotypes. Although AUCs were numerically higher in non-shock sepsis, between-phenotype differences were not statistically significant, supporting phenotype-based interpretation and the need for external validation. FAU - Vo, Thi Van AU - Vo TV AD - Department of Pediatrics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam. FAU - Lu, Dien Tri AU - Lu DT AD - Department of General Nursing, Internal Medicine Program, Faculty of Nursing and Medical Technology, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam. FAU - Thai, Dien Minh AU - Thai DM AD - Faculty of Medicine, Nam Can Tho University, Can Tho, Vietnam. LA - eng PT - Journal Article DEP - 20260803 PL - Iran TA - Arch Acad Emerg Med JT - Archives of academic emergency medicine JID - 101740147 PMC - PMC13542529 OTO - NOTNLM OT - Biomarkers OT - Lactic acid OT - Pediatrics OT - Procalcitonin OT - Sepsis OT - Shock, septic COIS- The authors declare no conflict of interest. EDAT- 2026/09/06 01:18 MHDA- 2026/09/06 01:19 PMCR- 2026/08/03 CRDT- 2026/09/05 09:05 PHST- 2026/09/06 01:19 [medline] PHST- 2026/09/06 01:18 [pubmed] PHST- 2026/09/05 09:05 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - 10.22037/aaem.v14i1.3029 [doi] PST - epublish SO - Arch Acad Emerg Med. 2026 Aug 3;14(1):e34. doi: 10.22037/aaem.v14i1.3029. eCollection 2026. PMID- 42697107 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261024 IS - 2211-0356 (Electronic) IS - 2211-0348 (Linking) VI - 115 DP - 2026 Nov TI - Longitudinal stability of dietary intake patterns in pediatric-onset multiple sclerosis: A multicenter prospective cohort study. PG - 107677 LID - S2211-0348(26)00712-1 [pii] LID - 10.1016/j.msard.2026.107677 [doi] AB - BACKGROUND: Diet may influence MS activity, but most studies use a single dietary measure. The stability of diet over time in pediatric-onset MS (POMS) is unclear. OBJECTIVES: To evaluate the reproducibility and short-term temporal stability of dietary intake in youth with POMS using repeated food frequency questionnaires (FFQ). METHODS: This longitudinal study included participants with a baseline FFQ (the Block Kids Food Screener, 2014). Intraclass correlation coefficients (ICCs) were estimated using random-intercept mixed-effects models to quantify the relative contributions of between-person and within-person variability. Temporal trends in intake were assessed by modeling time since baseline as a fixed effect, using log-transformed dietary variables to estimate percent change over time. RESULTS: Of 419 FFQs from 195 participants, 140 (71.8%) completed >/=2 FFQs over a median of 6.5 months (range 2.8-18). ICCs ranged from 0.41 to 0.78 across dietary measures, with the highest reproducibility observed for vegetables and fiber (ICCs 0.78 and 0.72). Log-transformed models showed small declines in several nutrients over time, corresponding to <10% change over a six-month period. CONCLUSIONS: Dietary intake demonstrated moderate to good reproducibility over the 6 to 18 month follow-up period. Vegetable and fiber intake had the strongest reliability. These findings suggest that reported dietary intake assessed by a single or infrequent FFQ may remain reasonably stable over a 6- to 18-month period in longitudinal POMS studies. However, the moderate-to-good reproducibility observed indicates that within-person variability persists and may attenuate diet-disease associations when only a single dietary assessment is available. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Virupakshaiah, Akash AU - Virupakshaiah A AD - UCSF School of Medicine, San Francisco, CA, USA. Electronic address: Akash.Virupakshaiah@ucsf.edu. FAU - Schoeps, Vinicius A AU - Schoeps VA AD - UCSF School of Medicine, San Francisco, CA, USA. FAU - Chang, Gina AU - Chang G AD - UCSF School of Medicine, San Francisco, CA, USA. FAU - Waltz, Michael AU - Waltz M AD - University of Utah, Salt Lake City, UT, USA. FAU - Race, Jonathan AU - Race J AD - University of Utah, Salt Lake City, UT, USA. FAU - Mar, Soe AU - Mar S AD - Washington University in St Louis School of Medicine, Department of Neurology, St. Louis, MO, USA. FAU - Francisco, Carla AU - Francisco C AD - UCSF School of Medicine, San Francisco, CA, USA. FAU - Casper, T Charles AU - Casper TC AD - University of Utah, Salt Lake City, UT, USA. FAU - Rose, John AU - Rose J AD - University of Utah, Salt Lake City, UT, USA. FAU - Rodriguez, Moses AU - Rodriguez M AD - Mayo Clinic, Rochester, MN, USA. FAU - Tillema, Jan-Mendelt AU - Tillema JM AD - Mayo Clinic, Rochester, MN, USA. FAU - Chitnis, Tanuja AU - Chitnis T AD - Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Gorman, Mark P AU - Gorman MP AD - Boston Children's Hospital, Boston, MA, USA. FAU - Benson, Leslie A AU - Benson LA AD - Boston Children's Hospital, Boston, MA, USA. FAU - Graves, Jennifer S AU - Graves JS AD - Department of Neurosciences, University of California, San Diego, CA, USA. FAU - Rensel, Mary AU - Rensel M AD - Cleveland Clinic, Cleveland, OH, USA. FAU - Abrams, Aaron AU - Abrams A AD - Cleveland Clinic, Cleveland, OH, USA. FAU - Krupp, Lauren B AU - Krupp LB AD - NYU Langone Health, NY, NY, USA. FAU - O'Neill, Kimberly A AU - O'Neill KA AD - NYU Langone Health, NY, NY, USA. FAU - Lotze, Timothy E AU - Lotze TE AD - Texas Children's Hospital, Houston, TX, USA. FAU - Aaen, Gregory AU - Aaen G AD - Loma Linda University Children's Hospital, Loma Linda, CA, USA. FAU - Wheeler, Yolanda AU - Wheeler Y AD - University of Alabama at Birmingham, Birmingham, AL, USA. FAU - Schreiner, Teri AU - Schreiner T AD - Children's Hospital Colorado, Denver, CO, USA. FAU - Waldman, Amy T AU - Waldman AT AD - Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Chong, Janet AU - Chong J AD - UCSF School of Medicine, San Francisco, CA, USA. FAU - Titcomb, Tyler J AU - Titcomb TJ AD - Department of Dietetics and Nutrition, University of Kansas Medical Center, United States. FAU - Tremlett, Helen AU - Tremlett H AD - Division of Neurology, Department of Medicine, The University of British Columbia, Canada. FAU - Waubant, Emmanuelle AU - Waubant E AD - UCSF School of Medicine, San Francisco, CA, USA. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260823 PL - Netherlands TA - Mult Scler Relat Disord JT - Multiple sclerosis and related disorders JID - 101580247 SB - IM MH - Humans MH - Female MH - Longitudinal Studies MH - Adolescent MH - Male MH - Child MH - Reproducibility of Results MH - *Multiple Sclerosis/epidemiology MH - *Diet MH - Prospective Studies MH - Diet Surveys MH - *Feeding Behavior MH - Age of Onset OTO - NOTNLM OT - Diet OT - Dietary assessment OT - Food frequency questionnaire OT - Pediatric-onset multiple sclerosis COIS- Declaration of competing interest None reported. EDAT- 2026/09/04 23:36 MHDA- 2026/10/24 05:34 CRDT- 2026/09/04 18:10 PHST- 2026/03/14 00:00 [received] PHST- 2026/07/13 00:00 [revised] PHST- 2026/08/21 00:00 [accepted] PHST- 2026/10/24 05:34 [medline] PHST- 2026/09/04 23:36 [pubmed] PHST- 2026/09/04 18:10 [entrez] AID - S2211-0348(26)00712-1 [pii] AID - 10.1016/j.msard.2026.107677 [doi] PST - ppublish SO - Mult Scler Relat Disord. 2026 Nov;115:107677. doi: 10.1016/j.msard.2026.107677. Epub 2026 Aug 23. PMID- 42693933 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20261002 IS - 1367-4811 (Electronic) IS - 1367-4803 (Print) IS - 1367-4803 (Linking) VI - 42 IP - 9 DP - 2026 Aug 31 TI - Revealing subject-specific temporal patterns from longitudinal data. LID - 10.1093/bioinformatics/btag658 [doi] LID - btag658 AB - MOTIVATION: Temporal multivariate data are ubiquitous in many domains, for instance, being collected over time at planned visits (every few months/years) in longitudinal cohorts, or every few minutes/hours in challenge tests. The analysis of such data often focuses on revealing the underlying temporal patterns common across subjects. However, there are subject-specific differences in temporal patterns, which hold the promise to enhance our understanding of underlying mechanisms and facilitate personalized approaches. Nevertheless, extracting subject-specific temporal patterns from longitudinal multivariate data reliably is an open challenge. RESULTS: We introduce coupled matrix factorizations (CMFs) as effective tools to capture subject-specific temporal patterns focusing on two novel applications: analysis of longitudinal metabolomics data and sensitization data. Our analysis shows that CMF models reliably capture subject-specific (shape) differences in temporal patterns with the promise to reveal further insights compared to the state of the art. In metabolomics, CMF models reveal differences in metabolic responses of individuals (in a postprandial meal challenge) according to anthropometric and insulin sensitivity measures. In sensitization data analysis, CMF-based methods capture differences in temporal trajectories of children according to delivery/birth mode and atopic disease diagnosis. We demonstrate the reliability of extracted patterns using reproducibility and replicability. AVAILABILITY AND IMPLEMENTATION: The code is available on github.com/cchatzis/Revealing-Subject-specific-Temporal-Patterns-from-Longitudinal-Data and doi.org/10.5281/zenodo.22084338. Clinical data are not publicly available due to privacy reasons. Data can be made available under a joint research collaboration by contacting COPSAC (administration@dbac.dk). CI - (c) The Author(s) 2026. Published by Oxford University Press. FAU - Chatzis, Christos AU - Chatzis C AD - Department of Data Science and Knowledge Discovery, Simula Metropolitan Center for Digital Engineering, Oslo, 0170, Norway. AD - Faculty of Technology, Art and Design, Oslo Metropolitan University, Oslo, 0166, Norway. FAU - Horner, David AU - Horner D AUID- ORCID: 0000-0002-0200-4561 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, 2820, Denmark. FAU - Bro, Rasmus AU - Bro R AD - Department of Food Science, University of Copenhagen, Copenhagen, 1958, Denmark. FAU - Schoos, Ann-Marie Malby AU - Schoos AM AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, 2820, Denmark. AD - Department of Pediatrics, Copenhagen University Hospital-Naestved, Slagelse and Ringsted, Slagelse, 4200, Denmark. AD - Department of Pediatrics, Copenhagen University Hospital-Amager and Hvidovre, Hvidovre, 2650, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, 2200, Denmark. FAU - Rasmussen, Morten A AU - Rasmussen MA AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, 2820, Denmark. AD - Department of Food Science, University of Copenhagen, Copenhagen, 1958, Denmark. FAU - Acar, Evrim AU - Acar E AUID- ORCID: 0000-0002-3737-292X AD - Department of Data Science and Knowledge Discovery, Simula Metropolitan Center for Digital Engineering, Oslo, 0170, Norway. LA - eng GR - NNF23SA0087869/Novo Nordisk Foundation/ PT - Journal Article PL - England TA - Bioinformatics JT - Bioinformatics (Oxford, England) JID - 9808944 SB - IM MH - Humans MH - *Metabolomics/methods MH - Longitudinal Studies MH - Algorithms MH - *Computational Biology/methods PMC - PMC13623513 COIS- Ann-Marie Malby Schoos has received payment as a speaker from Thermo Fisher Scientific. EDAT- 2026/09/04 05:35 MHDA- 2026/09/30 05:30 PMCR- 2026/09/04 CRDT- 2026/09/04 04:13 PHST- 2026/01/30 00:00 [received] PHST- 2026/07/27 00:00 [revised] PHST- 2026/08/18 00:00 [accepted] PHST- 2026/09/30 05:30 [medline] PHST- 2026/09/04 05:35 [pubmed] PHST- 2026/09/04 04:13 [entrez] PHST- 2026/09/04 00:00 [pmc-release] AID - 8785290 [pii] AID - btag658 [pii] AID - 10.1093/bioinformatics/btag658 [doi] PST - ppublish SO - Bioinformatics. 2026 Aug 31;42(9):btag658. doi: 10.1093/bioinformatics/btag658. PMID- 42693541 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260914 IS - 1478-5153 (Electronic) IS - 1362-1017 (Print) IS - 1362-1017 (Linking) VI - 31 IP - 5 DP - 2026 Sep TI - Wearable Sleep and Circadian Monitoring in Intensive Care Nursing: A Scoping Review. PG - e70671 LID - 10.1111/nicc.70671 [doi] LID - e70671 AB - BACKGROUND: Sleep and circadian disruption are common in critical illness, yet bedside assessment remains difficult. Wearables are unobtrusive and extend observation across 24 h, but their measurement performance in critical illness requires appraisal. AIMS: To map wearable sleep and circadian monitoring during intensive care, its measurement performance, clinical applications and nursing implications. STUDY DESIGN: A scoping review followed JBI and PRISMA-ScR guidance. PubMed, Europe PMC and OpenAlex were searched from inception to 22 July 2026, with citation searching. Eligible primary reports used a body-worn sensor during intensive care to estimate sleep or circadian/rest-activity outcomes at any age. Conventional polysomnography/electroencephalography without an eligible wearable, non-contact systems, staff studies and post-ICU-only monitoring were excluded. No risk-of-bias appraisal was undertaken. RESULTS: Sixty-one reports (43 adult; 18 paediatric/neonatal; 1996-2026) were included. Actigraphy dominated; commercial trackers, smartwatches and one respiratory-belt/heart-rate-variability system were less common. Monitoring was feasible, but performance varied by device, patient state and age group: wake specificity was often poor in ventilated, sedated or immobile patients and agreement with patient or nurse reports was weak to modest. Records showed fragmented and daytime sleep, weak day-night consolidation and attenuated circadian rhythmicity. Nursing bundles, massage, positioning, light and chronotype-informed care changed selected outcomes, but effects were heterogeneous. CONCLUSIONS: Wearables usefully describe rest-activity patterns and support nursing assessment, but agreement with physiological sleep varied by device, patient state and age; movement-derived estimates need clinical context and are not a stand-alone sleep measure. RELEVANCE TO CLINICAL PRACTICE: Nurses should combine wearable trends with patient report, sedation and mobility, delirium screening and care-interaction records; escalation thresholds require prospective validation. CI - (c) 2026 British Association of Critical Care Nurses. FAU - Badawy, Walaa AU - Badawy W AUID- ORCID: 0000-0002-8154-0038 AD - College of Education, King Khalid University, Abha, Saudi Arabia. FAU - Shaban, Mostafa AU - Shaban M AUID- ORCID: 0000-0001-7822-1653 AD - Community Health Nursing Department, College of Nursing, Jouf University, Sakaka, Saudi Arabia. LA - eng GR - RGP2/129/47/Deanship of Research and Graduate Studies at King Khalid University/ PT - Journal Article PT - Scoping Review PL - England TA - Nurs Crit Care JT - Nursing in critical care JID - 9808649 SB - IM MH - Humans MH - *Critical Care Nursing MH - *Wearable Electronic Devices MH - *Sleep/physiology MH - *Circadian Rhythm/physiology MH - Monitoring, Physiologic/instrumentation MH - Actigraphy MH - Polysomnography MH - Intensive Care Units MH - Critical Illness PMC - PMC13542315 OTO - NOTNLM OT - actigraphy OT - circadian rhythm OT - critical care nursing OT - intensive care units OT - sleep monitoring COIS- The authors declare no conflicts of interest. EDAT- 2026/09/04 05:36 MHDA- 2026/09/04 05:37 PMCR- 2026/09/04 CRDT- 2026/09/04 01:50 PHST- 2026/08/15 00:00 [revised] PHST- 2026/07/23 00:00 [received] PHST- 2026/08/21 00:00 [accepted] PHST- 2026/09/04 05:37 [medline] PHST- 2026/09/04 05:36 [pubmed] PHST- 2026/09/04 01:50 [entrez] PHST- 2026/09/04 00:00 [pmc-release] AID - NICC70671 [pii] AID - 10.1111/nicc.70671 [doi] PST - ppublish SO - Nurs Crit Care. 2026 Sep;31(5):e70671. doi: 10.1111/nicc.70671. PMID- 42692871 OWN - NLM STAT- Publisher LR - 20260903 IS - 1878-4046 (Electronic) IS - 1076-6332 (Linking) DP - 2026 Sep 3 TI - Value of the Newly Designed Major and Minor Checklists in Diagnosis of Congenital Cardiovascular Disease and Associated Malformation: New Era of Fetal Cardiac MRI. LID - S1076-6332(26)00583-0 [pii] LID - 10.1016/j.acra.2026.07.071 [doi] AB - RATIONALE AND OBJECTIVES: Fetal echocardiography is the standard, rapid, affordable, and noninvasive modality for prenatal assessment of suspected congenital heart disease. Fetal cardiac magnetic resonance imaging (FCMRI) has emerged as a valuable adjunct, particularly when ultrasound is limited by maternal obesity, uterine fibroids, oligohydramnios, fetal malposition, or late-gestational acoustic shadowing. Consequently, this study aimed to evaluate the diagnostic utility of a newly proposed structured major/minor checklist system for FCMRI interpretation. By correlating structured FCMRI interpretations with postnatal echocardiographic outcomes, we assess the framework's reliability in characterizing structural cardiovascular anomalies, particularly when initial ultrasound evaluation is suboptimal. MATERIALS AND METHODS: Between May 2024 and November 2025, an initial cohort of 60 pregnant women was screened, yielding 52 singleton pregnancies with suspected fetal cardiac anomalies. These cases were prospectively evaluated with fetal echocardiography and FCMRI. Image interpretation was performed by two radiologists experienced in prenatal imaging and one pediatric cardiologist. Postnatal confirmation was available for 40 live-born infants; 12 intrauterine fetal death cases were excluded from postnatal diagnostic-performance analysis. RESULTS: Based on postnatal echocardiography, both modalities demonstrated high diagnostic performance. Fetal echocardiography yielded slightly higher sensitivity than FCMRI (96.5% vs. 93.1%), whereas FCMRI exhibited higher specificity (100% vs. 81.8%) and overall diagnostic accuracy (95.0% vs. 92.5%). Notably, FCMRI demonstrated a significantly higher overall concordance with postnatal echocardiography compared to fetal echocardiography for ductus-dependent critical lesions (90.0% vs. 77.5% total agreement). This superior concordance for FCMRI was particularly pronounced in identifying emergency ductus-dependent lesions (72.7% vs. 36.4% agreement in positive cases), alongside higher exact concordance in normal, conotruncal, and hypoplastic heart-spectrum categories, whereas fetal echocardiography showed higher concordance in tetralogy of Fallot and Ebstein anomaly. Both modalities showed similar concordance for atrioventricular septal defects. CONCLUSION: FCMRI is a useful complementary adjunct to fetal echocardiography, improving diagnostic confidence in complex cases and supporting prenatal counseling, delivery planning, and postnatal management. CI - Copyright (c) 2026 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved. FAU - Hassan, Hend Galal Eldeen Mohamed Ali AU - Hassan HGEMA AD - Department of Diagnostic, Interventional Radiology and Molecular Imaging, Faculty of Medicine, Ain Shams University, Cairo, Egypt. FAU - Ragheb, Samar Ramzy AU - Ragheb SR AD - Department of Diagnostic, Interventional Radiology and Molecular Imaging, Faculty of Medicine, Ain Shams University, Cairo, Egypt. FAU - Elyasaki, Ahmed M AU - Elyasaki AM AD - Technology of Prosthetic & Orthotic Devices Program, Faculty of Applied Health Sciences, Galala University, Suez, Egypt; Rheumatology, Rehabilitation and Physical Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. FAU - M M Habeeb, Nevin AU - M M Habeeb N AD - Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. FAU - G Khattap, Mohamed AU - G Khattap M AD - Technology of Radiology and Medical Imaging Program, Faculty of Applied Health Sciences Technology, Galala University, Suez 435611, Egypt. Electronic address: mohamed.khattap.2016@gmail.com. LA - eng PT - Journal Article DEP - 20260903 PL - United States TA - Acad Radiol JT - Academic radiology JID - 9440159 SB - IM OTO - NOTNLM OT - Congenital heart disease OT - Disease-spectrum classification OT - Fetal cardiac MRI OT - Fetal echocardiography OT - Major and minor checklists COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/03 23:36 MHDA- 2026/09/03 23:36 CRDT- 2026/09/03 21:52 PHST- 2026/05/27 00:00 [received] PHST- 2026/07/19 00:00 [revised] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/09/03 23:36 [medline] PHST- 2026/09/03 23:36 [pubmed] PHST- 2026/09/03 21:52 [entrez] AID - S1076-6332(26)00583-0 [pii] AID - 10.1016/j.acra.2026.07.071 [doi] PST - aheadofprint SO - Acad Radiol. 2026 Sep 3:S1076-6332(26)00583-0. doi: 10.1016/j.acra.2026.07.071. PMID- 42692055 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260911 IS - 1873-4030 (Electronic) IS - 1350-4533 (Linking) VI - 147 IP - 9 DP - 2026 Sep 11 TI - Anthropometry-aware chest-worn inertial sensing for pediatric activity assessment using a school-badge device. LID - 10.1088/1873-4030/aea226 [doi] AB - Objective assessment of physical activity in children and adolescents supports school health surveillance and the evaluation of behavioral interventions, but wearable recognition models are typically developed on adults, public benchmarks, or sample-level data splits that do not test performance on new users. Baseline models also encode the inertial stream alone and carry no description of the individual, leaving developmental differences in body size and movement execution uncorrected. This study developed the Anthropometry-Aware Temporal Attention DeepConvLSTM (AATA-DeepConvLSTM) model for single-label 22-class activity recognition from a chest-worn school-badge inertial measurement unit. It combines convolutional-recurrent encoding of eight inertial channels (triaxial acceleration and angular velocity at 100 Hz plus their magnitudes), temporal attention pooling, and representation-level fusion of age, sex, height, body weight, and body mass index as subject-level context. After quality control, 4,666 activity records from 128 participants aged 5-18 years were analyzed under subject-independent five-fold cross-validation, with record-level macro-averaged1 (Macro-1) as the primary metric. AATA-DeepConvLSTM reached a record-level accuracy of 0.9377 and a Macro-1 of 0.9291, against 0.9092 and 0.8992 for the strongest baseline, DeepConvLSTM. In ablation, temporal attention alone raised Macro-1 from 0.8992 to 0.9112 and real anthropometric context raised it to 0.9291, whereas shuffling the anthropometric values across participants returned it to 0.9117; height alone recovered 0.9264. Static postures remained the weakest classes. These results support anthropometry-aware wearable-signal modeling as a feasible engineering approach for pediatric activity assessment, while naturalistic validation and stable calibration protocols remain necessary before routine school-based deployment. CI - (c) 2026 Institute of Physics and Engineering in Medicine. All rights, including for text and data mining, AI training, and similar technologies, are reserved. FAU - Yang, Zhiyuan AU - Yang Z AUID- ORCID: 0009-0008-1495-4784 AD - Tianjin University of Sport, Tianjin, People's Republic of China. FAU - Li, Liang AU - Li L AD - China Institute of Sport Science, Beijing, People's Republic of China. FAU - Cai, Yujun AU - Cai Y AUID- ORCID: 0009-0003-6827-6708 AD - Shanghai University of Sport, Shanghai, People's Republic of China. FAU - Sun, Zhiyuan AU - Sun Z AD - Shandong Sport University, Jinan, People's Republic of China. FAU - Tao, Liangze AU - Tao L AD - School of Automation, Southeast University, Nanjing, People's Republic of China. FAU - Bao, Chunyu AU - Bao C AD - Tianjin University of Sport, Tianjin, People's Republic of China. FAU - Meng, Qinghua AU - Meng Q AD - Tianjin University of Sport, Tianjin, People's Republic of China. FAU - Li, Xuesong AU - Li X AD - Qufu Normal University, Qufu, People's Republic of China. FAU - Xue, Yijia AU - Xue Y AD - Tianjin University of Sport, Tianjin, People's Republic of China. FAU - Xiong, Kai AU - Xiong K AD - Zhongyuan University of Technology, Zhengzhou, People's Republic of China. FAU - Yan, Longxin AU - Yan L AD - Zhongyuan University of Technology, Zhengzhou, People's Republic of China. FAU - Bu, Can AU - Bu C AD - School of Automation, Southeast University, Nanjing, People's Republic of China. LA - eng PT - Journal Article DEP - 20260911 PL - England TA - Med Eng Phys JT - Medical engineering & physics JID - 9422753 SB - IM MH - Humans MH - Child MH - Adolescent MH - *Wearable Electronic Devices MH - Male MH - Female MH - *Anthropometry/instrumentation MH - Child, Preschool MH - *Schools MH - *Accelerometry/instrumentation OTO - NOTNLM OT - anthropometric information OT - biomedical engineering OT - few-shot personalization OT - human activity recognition OT - pediatric activity assessment OT - subject-independent validation OT - wearable inertial sensing EDAT- 2026/09/03 23:36 MHDA- 2026/09/11 17:36 CRDT- 2026/09/03 18:53 PHST- 2026/06/24 00:00 [received] PHST- 2026/09/03 00:00 [accepted] PHST- 2026/09/11 17:36 [medline] PHST- 2026/09/03 23:36 [pubmed] PHST- 2026/09/03 18:53 [entrez] AID - 10.1088/1873-4030/aea226 [doi] PST - epublish SO - Med Eng Phys. 2026 Sep 11;147(9). doi: 10.1088/1873-4030/aea226. PMID- 42689455 OWN - NLM STAT- Publisher LR - 20260903 IS - 1539-2570 (Electronic) IS - 0271-6798 (Linking) DP - 2026 Sep 3 TI - A Simplified Method for Talocalcaneal Coalition Excision. LID - 10.1097/BPO.0000000000003456 [doi] AB - BACKGROUND: Talocalcaneal (TC) coalitions are a common cause of hindfoot pain in adolescents. Resection is effective when the posterior facet is preserved but can be technically demanding, with risk of incomplete resection and prolonged operative time. This study describes a simplified technique for TC coalition excision and compares its outcomes with traditional methods. METHODS: A retrospective review was performed of patients undergoing isolated TC coalition excision with autogenous fat graft interposition at a single pediatric institution (2001 to 2025). Patients with prior surgery, neuromuscular or syndromic conditions, or concomitant procedures were excluded. Forty-eight patients (54 feet) met the inclusion criteria: 39 feet underwent traditional excision, and 15 feet underwent a simplified technique using converging Kirschner wires to guide resection. Outcomes included tourniquet time, anesthesia time, procedural cost, and perioperative complications. Costs were estimated using institutional per-minute operating room rates. Statistical significance was set at P<0.05. RESULTS: There were no differences between groups in age, sex, body mass index, or prevalence of flatfoot deformity. The traditional group had a higher proportion of osseous coalitions (51.3% vs. 13.3%, P=0.04). Tourniquet time (93.4+/- 20.5 vs. 47.5+/- 9.9 min, P<0.0001), total anesthesia time (118.6+/-30.9 vs. 58.9+/-14.2, P<0.0001), direct cost ($1987 vs. $986, P<0.0001), and total cost ($5819 vs. $2887, P<0.0001) were all significantly lower in the simplified method group. No perioperative complications occurred in either group. At a mean follow-up of 2.1 years (range: 0.10 to 8.2 y), there were no differences in complications or secondary procedures. CONCLUSION: The simplified technique for TC coalition excision using converging Kirschner wires is associated with reduced operative time and cost without increased complications. This method provides a reproducible and efficient alternative to traditional resection techniques. LEVEL OF EVIDENCE: Level III-therapeutic. CI - Copyright (c) 2026 Wolters Kluwer Health, LLC. All rights reserved. FAU - Lam, Aaron AU - Lam A AD - Baylor Scott and White Orthopedic Associates of Dallas. FAU - Hartman, Rusty AU - Hartman R AD - Scottish Rite for Children, Dallas, TX. FAU - Coe, Kelsie M AU - Coe KM AD - Penn State Health, Hershey, PA. FAU - O'Sullivan, Michael AU - O'Sullivan M AD - Children's Health Ireland at Temple Street Hospital, Dublin, Ireland. FAU - Zide, Jacob AU - Zide J AD - Baylor Scott and White Orthopedic Associates of Dallas. AD - Scottish Rite for Children, Dallas, TX. FAU - Riccio, Anthony I AU - Riccio AI AUID- ORCID: 0000-0002-8386-9312 AD - Scottish Rite for Children, Dallas, TX. LA - eng PT - Journal Article DEP - 20260903 PL - United States TA - J Pediatr Orthop JT - Journal of pediatric orthopedics JID - 8109053 SB - IM OTO - NOTNLM OT - coalition OT - coalition excision OT - coalition excision technique OT - kirschner wires OT - talocalcaneal coalition COIS- The authors declare no conflicts of interest. EDAT- 2026/09/03 17:36 MHDA- 2026/09/03 17:36 CRDT- 2026/09/03 11:19 PHST- 2026/09/03 17:36 [medline] PHST- 2026/09/03 17:36 [pubmed] PHST- 2026/09/03 11:19 [entrez] AID - 01241398-990000000-01295 [pii] AID - 10.1097/BPO.0000000000003456 [doi] PST - aheadofprint SO - J Pediatr Orthop. 2026 Sep 3. doi: 10.1097/BPO.0000000000003456. PMID- 42689310 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 0970-0218 (Print) IS - 1998-3581 (Electronic) IS - 0970-0218 (Linking) VI - 51 IP - 4 DP - 2026 Jul-Aug TI - In-Service Training of Stakeholders Working for Particularly Vulnerable Tribal Groups (PVTGs) in an Eastern State of India: A Pre and Post- Training Assessment. PG - 686-693 LID - 10.4103/ijcm.ijcm_693_25 [doi] AB - BACKGROUND: Particularly vulnerable tribal groups (PVTGs) are among the most marginalized tribal communities in India. The uptake of government-led health and nutrition programmes by them is low owing to the geographical remoteness of their habitats, communication gaps between service providers and PVTG communities, and distinct cultural beliefs. Under the "Jiban Sampark" ("Connection with Life") project-a collaboration between the Government of Odisha, United Nations Children's Fund (UNICEF), and AIIMS Bhubaneswar-a structured training of trainers (ToT) programme was implemented to build the capacity of stakeholders serving these communities. The objective of this study was to implement and assess the effectiveness of the training programme on the knowledge of stakeholders working for PVTGs in tribal districts of Odisha, an eastern state of India. METHODS: A single-group pre-post (before-after) interventional study was conducted in 12 tribal districts from April 2019 to January 2020. Six modules were developed and vetted by subject experts for the training of different stakeholders including health officials, officials from Women and Child Development (WCD) departments, Non-Governmental Organization (NGO) personnel, and functionaries of the Odisha Livelihood Mission (OLM) and the Odisha PVTG Empowerment and Livelihood Programme (OPELIP). Three-day residential trainings covered six modules; knowledge was assessed across five domains-childhood malnutrition, adolescent health, antenatal and postnatal care, newborn care and immunization, and communication in service delivery-using a pretested, content-validated 20-item questionnaire administered immediately before and after training to 231 of the 242 participants trained. RESULTS: The mean total knowledge score improved significantly after training compared with before training (13.80 +/- 3.78 vs 11.55 +/- 5.19; paired t-test, P < 0.001). All five domains improved significantly by McNemar's test (all P < 0.0001). The pre-test overall knowledge was lowest among OPELIP staff and health functionaries (8.41 +/- 3.03 and 9.16 +/- 2.49, respectively). The post-test scores of health functionaries were highest across all domains, and their overall improvement was statistically significant (9.16 +/- 2.49 vs 15.48 +/- 4.19; P < 0.001). WCD functionaries, who had the highest baseline score, showed a significant decline in total score (14.85 +/- 6.37 vs 12.82 +/- 3.96; P = 0.023). CONCLUSION: The assessment of pre- and post-test results revealed a significant improvement in the knowledge of stakeholders across most domains and cadres. Hence, an administrative mechanism within the government system is needed to impart training to all stakeholders at regular intervals and to monitor the cascade training of frontline workers (FLWs). CI - Copyright: (c) 2026 Indian Journal of Community Medicine. FAU - Bhatia, Vikas AU - Bhatia V AD - Department of Community Medicine and Family Medicine, AIIMS Bhubaneswar, Odisha, India. FAU - Giri, Prajna Paramita AU - Giri PP AD - Department of Community Medicine and Family Medicine, AIIMS Bhubaneswar, Odisha, India. FAU - Taywade, Manish AU - Taywade M AD - Department of Community Medicine and Family Medicine, AIIMS Bhubaneswar, Odisha, India. FAU - Parida, Swayam Pragyan AU - Parida SP AD - Department of Community Medicine and Family Medicine, AIIMS Bhubaneswar, Odisha, India. FAU - Behera, Binod Kumar AU - Behera BK AD - Department of Community Medicine and Family Medicine, AIIMS Bhubaneswar, Odisha, India. FAU - Das, Sandeep AU - Das S AD - Department of Community Medicine and Family Medicine, AIIMS Bhubaneswar, Odisha, India. LA - eng PT - Journal Article DEP - 20260813 PL - India TA - Indian J Community Med JT - Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine JID - 9315574 PMC - PMC13537773 OTO - NOTNLM OT - Knowledge assessment OT - PVTG OT - scheduled tribe OT - training OT - tribal COIS- There are no conflicts of interest. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/07/01 CRDT- 2026/09/03 11:08 PHST- 2025/09/11 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 11:08 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - IJCM-51-686 [pii] AID - 10.4103/ijcm.ijcm_693_25 [doi] PST - ppublish SO - Indian J Community Med. 2026 Jul-Aug;51(4):686-693. doi: 10.4103/ijcm.ijcm_693_25. Epub 2026 Aug 13. PMID- 42688803 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - The moderated mediation effect of physical activity on non-suicidal self-injury: the mediating role of perceived stress and the moderating role of parental support. PG - 1824693 LID - 10.3389/fpsyt.2026.1824693 [doi] LID - 1824693 AB - OBJECTIVES: Non-suicidal self-injury (NSSI) has emerged as a significant public health challenge among adolescents globally. Although physical activity (PA) is widely recognized as a potential protective factor for mental health, the internal mechanisms through which it is associated with specific high-risk behaviors like NSSI remain insufficiently explored. This study aims to construct and validate a moderated mediation model to examine the association between PA and adolescent NSSI, the mediating role of perceived stress, and the boundary conditions set by parental support. METHODS: Utilizing a cross-sectional observational design and a stratified cluster sampling method, 402 adolescents (198 males and 204 females; mean age = 15.23 +/- 1.57 years) were recruited from five middle and high schools (three urban, two rural) in Sichuan Province, China. Participants completed a battery of psychometric instruments, including the Physical Activity Rating Scale-3 (PARS-3), the Perceived Stress Scale-10 (PSS-10), the Inventory of Parent and Peer Attachment (IPPA), and the Deliberate Self-Harm Inventory (DSHI). Data analysis was conducted using SPSS 26.0 and the PROCESS macro (Model 58). RESULTS: PA was significantly and negatively associated with adolescent NSSI (beta = -0.58, p < 0.001). Perceived stress partially mediated this relationship, with the indirect association accounting for 36.21% of the total effect. The substantial direct association (63.79%) suggests that PA may also relate to NSSI through other unmeasured pathways, such as speculative neurobiological adaptations or behavioral replacement. Furthermore, parental support significantly moderated the mediated process. Specifically, parental support moderated both the PA -> perceived stress pathway (beta = 0.15, p = 0.003) and the perceived stress -> NSSI pathway (beta = -0.14, p = 0.005), suggesting that the negative association between PA and stress is stronger under low parental support. CONCLUSIONS: PA serves as a potential protective factor negatively associated with NSSI through both direct and indirect statistical pathways. Parental support functions as a critical environmental buffer; for adolescents lacking parental support, PA serves as a crucial compensatory resource for stress management. These findings offer empirical evidence for the development of integrated family-school intervention strategies for adolescent mental health. CI - Copyright (c) 2026 Wang, Jia and Xu. FAU - Wang, Pengyu AU - Wang P AD - School of Public Administration, Henan University of Economics and Law, Zhengzhou, China. FAU - Jia, Hui AU - Jia H AD - Department of Marine-Sports, Pukyong National University, Busan, Republic of Korea. FAU - Xu, Jie AU - Xu J AD - Sichuan Technology and Business University, Meishan, China. LA - eng PT - Journal Article DEP - 20260819 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13535768 OTO - NOTNLM OT - moderated mediation OT - non-suicidal self-injury (NSSI) OT - parental support OT - perceived stress OT - physical activity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/08/19 CRDT- 2026/09/03 09:56 PHST- 2026/03/06 00:00 [received] PHST- 2026/06/30 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 09:56 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1824693 [doi] PST - epublish SO - Front Psychiatry. 2026 Aug 19;17:1824693. doi: 10.3389/fpsyt.2026.1824693. eCollection 2026. PMID- 42688474 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - Cultural adaptation, validation, and first application of the Canadian assessment of physical literacy (CAPL-2) in Lithuanian primary school children. PG - 1922697 LID - 10.3389/fspor.2026.1922697 [doi] LID - 1922697 AB - INTRODUCTION: Physical literacy is increasingly recognized as a multidimensional construct that supports lifelong engagement in physical activity. Although the Canadian Assessment of Physical Literacy, second edition (CAPL-2), is one of the most widely used instruments for assessing physical literacy in children, no culturally adapted and validated Lithuanian version has previously been available. This study aimed to translate and culturally adapt CAPL-2 for Lithuanian primary school children, evaluate its psychometric properties, and report the findings from its first application in a national sample. METHODS: CAPL-2 was translated and culturally adapted following established international guidelines, including forward-backward translation, expert review, and pilot testing. The adapted instrument was administered to 846 children aged 8-11 years from 10 Lithuanian schools. Descriptive statistics, Pearson correlations, confirmatory factor analysis, age- and sex-group comparisons, and internal consistency analyses were performed. RESULTS: The Lithuanian CAPL-2 demonstrated good psychometric properties and retained the original four-domain structure (CFI = .963, TLI = .946, RMSEA = .047, SRMR = .040). The Motivation and Confidence domain showed good internal consistency (Cronbach's alpha = .867; McDonald's omega = .87). The mean total CAPL-2 score was 70.25/100. Motivation and Confidence showed the highest domain scores, whereas Knowledge and Understanding demonstrated the weakest associations with the remaining domains and no significant correlation with Daily Behavior. Significant age-related differences were observed for Physical Competence and Knowledge and Understanding. CONCLUSION: The Lithuanian version of CAPL-2 is a valid and culturally appropriate instrument for assessing physical literacy in primary school children. The findings support its use in research, education, and public health and provide a foundation for future national and international studies. CI - (c) 2026 Vizbariene, Mieziene, Rutkauskaite and Emeljanovas. FAU - Vizbariene, Audrone AU - Vizbariene A AD - Department of Physical and Social Education, Lithuanian Sports University, Kaunas, Lithuania. FAU - Mieziene, Brigita AU - Mieziene B AD - Department of Physical and Social Education, Lithuanian Sports University, Kaunas, Lithuania. FAU - Rutkauskaite, Renata AU - Rutkauskaite R AD - Department of Physical and Social Education, Lithuanian Sports University, Kaunas, Lithuania. FAU - Emeljanovas, Arunas AU - Emeljanovas A AD - Department of Physical and Social Education, Lithuanian Sports University, Kaunas, Lithuania. LA - eng PT - Journal Article DEP - 20260819 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13534132 OTO - NOTNLM OT - CAPL-2 OT - cross-cultural adaptation and validation OT - physical education OT - physical literacy OT - primary school children COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor BO declared a past co-authorship/collaboration ("Compatibility of physical education curricula with physical literacy across 40 European countries") with the authors BM and AE. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/08/19 CRDT- 2026/09/03 08:59 PHST- 2026/06/29 00:00 [received] PHST- 2026/07/25 00:00 [revised] PHST- 2026/07/31 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 08:59 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - 10.3389/fspor.2026.1922697 [doi] PST - epublish SO - Front Sports Act Living. 2026 Aug 19;8:1922697. doi: 10.3389/fspor.2026.1922697. eCollection 2026. PMID- 42687936 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 2813-2890 (Electronic) IS - 2813-2890 (Linking) VI - 5 DP - 2026 TI - Exploring nightly variability in sleep apnea and changes in severity classification with multi night sleep testing in a population based cohort of young children. PG - 1903809 LID - 10.3389/frsle.2026.1903809 [doi] LID - 1903809 AB - BACKGROUND: Obstructive sleep apnea (OSA) is typically evaluated with single-night sleep studies. In adults, night-to-night variability (NtNV) is well documented, but less so in children. The current study evaluated NtNV in apnea events for misclassification in disease severity in young children to investigate if multi-night sleep-recordings may be clinically relevant to improve diagnostic accuracy and affect treatment decisions. METHODS: Parents/guardians of healthy 4-9-year-old children participating in a study to evaluate prevalence of OSA were asked to record the child's sleep for up to 5-nights. This analysis is from children who completed three consecutive night sleep recordings. RESULTS: Average age of participants was 6.1 years (n = 200, 58.0%-girls/42.0%-boys), prevalence of overweight/obesity was 25% and moderate-severe-OSA (AHI(3%) >/= 5) based on single-night testing protocol was 29.0%. Using the highest AHI(3%) value from the three recordings, the first-night correctly identified 57.0% of participants and adding a second night identified 86.0% of participants, with 14% of participants not identified until the third night of sleep testing.Bland-Altman plots (BA(plots)) demonstrated non-statistically significant mean-differences and 95% upper and lower-limits (LOA(95%)) close in absolute terms night-one/night-two; -0.024 events/hour-of-sleep LOA(95%) [-5.062, 5.013], 8.0% of observations outside the LOA(95%) (p = 0.894) and night-two/night-three; -0.009 events/hour of sleep, LOA(95%) [-5.227, 5.209] and 6.0% of observations outside LOA(95%), (p = 0.9620).The intra-class correlation coefficient (ICC) for AHI(3%) for all 3 nights was 0.45 [0.37, 0.54], p < 0.001, for night-one/night-two (0.44; p < 0.001), and night-two/night-three (0.44; p < 0.001). Cohens Kappa (0.304-0.462) and Brennan-Prediger Kappa (0.403-0.490), respectively indicated low-to-moderate interrater agreement, with quadratic-weighted Cohen's Kappa for the four ordinal severity categories of 0.37 and 0.48 for the two night-pairs, demonstrating NtNV, which is consistent with the variability demonstrated by the BA(plots). CONCLUSION: Observed NtNV in apnea events affected severity categorization, suggesting that multi-night sleep testing may have clinical value and improve accuracy of sleep apnea evaluation in young children. CLINICAL TRIAL REGISTRATION: URL: clinicaltrials.gov/study/NCT05479201, identifier NCT0547920 . CI - Copyright (c) 2026 Magnusdottir, Ingolfsdottir, Hilmisson, Hrolfsdottir, Birkisson, Hallgrimsdottir, Johannesdottir and Petersen. FAU - Magnusdottir, Solveig AU - Magnusdottir S AD - MyCardio LLC, Denver, CO, United States. FAU - Ingolfsdottir, Ingibjorg AU - Ingolfsdottir I AD - Akureyri Hospital, Pediatrics, Akureyri, Iceland. AD - University of Iceland, Reykjavik, Iceland. FAU - Hilmisson, Hugi AU - Hilmisson H AD - MyCardio LLC, Denver, CO, United States. FAU - Hrolfsdottir, Laufey AU - Hrolfsdottir L AD - Institution of Health Science Research, University of Akureyri and Akureyri Hospital, Akureyri, Iceland. FAU - Birkisson, Magnus AU - Birkisson M AD - Akureyri Hospital, Ear Nose Throat, Akureyri, Iceland. FAU - Hallgrimsdottir, Erla AU - Hallgrimsdottir E AD - Aarhus University, Aarhus, Denmark. FAU - Johannesdottir, Groa AU - Johannesdottir G AD - Akureyri Hospital, Pediatrics, Akureyri, Iceland. FAU - Petersen, Hannes AU - Petersen H AD - University of Iceland, Reykjavik, Iceland. AD - Akureyri Hospital, Ear Nose Throat, Akureyri, Iceland. LA - eng SI - ClinicalTrials.gov/NCT05479201 PT - Journal Article DEP - 20260819 PL - Switzerland TA - Front Sleep JT - Frontiers in sleep JID - 9918451286706676 PMC - PMC13533644 OTO - NOTNLM OT - apnea hypopnea index OT - children OT - diagnostic accuracy OT - night-to-night variability OT - sleep apnea COIS- SM was employed by MyCardio LLC. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author HP declared being an editorial board member of Vestibular Disorders, Frontiers in Audiology and Otology, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/08/19 CRDT- 2026/09/03 05:18 PHST- 2026/06/08 00:00 [received] PHST- 2026/07/03 00:00 [revised] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 05:18 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - 10.3389/frsle.2026.1903809 [doi] PST - epublish SO - Front Sleep. 2026 Aug 19;5:1903809. doi: 10.3389/frsle.2026.1903809. eCollection 2026. PMID- 42683142 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260902 LR - 20260903 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 8 DP - 2026 Aug TI - Quality Assessment of Complementary Feeding (CF) Practices Using CF Index and Determining Its Association With Sociodemographic Factors Among Children Aged 6-23 Months in District Etawah, Uttar Pradesh, India: A Community-Based Cross-Sectional Study. PG - e113808 LID - 10.7759/cureus.113808 [doi] LID - e113808 AB - BACKGROUND: Achieving nutritionally sufficient and well-timed supplementary feeding is central to sustaining physical growth, brain maturation, and immunological competence in infants and toddlers from 6 through 23 months. The Complementary Feeding Index (CFI) functions as an integrated multi-component instrument designed to quantify the overall adequacy of young child nutrition at the household level. OBJECTIVE: This investigation sought to appraise complementary feeding adequacy via the CFI and explore its associations with sociodemographic characteristics among children between 6 and 23 months of age in Etawah district, Uttar Pradesh, India. METHODS: This community-based cross-sectional analytical study recruited 416 children aged 6-23 months across rural and urban localities of Etawah district between January 2024 and February 2026. Household data were obtained through a validated, pre-piloted structured interview tool. CFI sub-indicators were evaluated: breastfeeding continuation, bottle use, age-appropriateness of complementary food introduction, dietary variety, food group coverage, and meal frequency. Anthropometric indices were measured with calibrated instruments, and all data were processed in Statistical Product and Service Solutions (SPSS, version 26.0; IBM SPSS Statistics for Windows, Armonk, NY). RESULTS: Breastfeeding was ongoing in 70.9% of children; 35.6% were bottle-fed. Supplementary foods at the recommended six-month milestone were given in 52.2% of cases. Minimum dietary diversity (MDD) was met by 22.1%, minimum meal frequency (MMF) by 59.4%, and minimum acceptable diet (MAD) by only 13.9%. Overall, CFI classification placed 43% of children in the appropriate and 57% in the inappropriate feeding category. CONCLUSION: Supplementary feeding quality in Etawah district is far below recommended thresholds, with 57% the children unable to achieve adequate dietary diversity or a MAD. Sustained investment in nutrition counselling, frontline workforce skill-building, and locally tailored community programmes is essential to reverse these deficits and improve child nutrition. CI - Copyright (c) 2026, Prajapati et al. FAU - Prajapati, Balram AU - Prajapati B AD - Community Medicine, Uttar Pradesh University of Medical Sciences (UPUMS), Saifai, IND. FAU - Maurya, Adarsh AU - Maurya A AD - Community Medicine, Uma Nath Singh Autonomous State Medical College, Jaunpur, IND. FAU - Prajapati, Neelam AU - Prajapati N AD - Physical Medicine and Rehabilitation, King George's Medical University (KGMU), Lucknow, IND. FAU - Rani, Vidya AU - Rani V AD - Community Medicine, Uttar Pradesh University of Medical Sciences (UPUMS), Saifai, IND. FAU - Singh, Naresh P AU - Singh NP AD - Community Medicine, Uttar Pradesh University of Medical Sciences (UPUMS), Saifai, IND. FAU - Jain, Pankaj AU - Jain P AD - Community Medicine, Uttar Pradesh University of Medical Sciences (UPUMS), Saifai, IND. FAU - Kaur, Gagan AU - Kaur G AD - Community Medicine, Uttar Pradesh University of Medical Sciences (UPUMS), Saifai, IND. FAU - Shukla, Sushil AU - Shukla S AD - Community Medicine, Uttar Pradesh University of Medical Sciences (UPUMS), Saifai, IND. LA - eng PT - Journal Article DEP - 20260802 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13532554 OTO - NOTNLM OT - complementary feeding OT - complementary feeding index OT - dietary diversity OT - infant and young child feeding OT - malnutrition COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Ethics Committee, Uttar Pradesh University of Medical Sciences, Saifai, Etawah (U.P.) issued approval 45/Cert./ICE/UPUMS/2024-2025. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/09/02 11:39 MHDA- 2026/09/02 11:40 PMCR- 2026/08/02 CRDT- 2026/09/02 09:01 PHST- 2026/07/31 00:00 [accepted] PHST- 2026/09/02 11:40 [medline] PHST- 2026/09/02 11:39 [pubmed] PHST- 2026/09/02 09:01 [entrez] PHST- 2026/08/02 00:00 [pmc-release] AID - 10.7759/cureus.113808 [doi] PST - epublish SO - Cureus. 2026 Aug 2;18(8):e113808. doi: 10.7759/cureus.113808. eCollection 2026 Aug. PMID- 42682444 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260902 LR - 20260903 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Physical activity relates to adolescent social anxiety: evidence from a structural equation model involving resilience and self-efficacy. PG - 1862222 LID - 10.3389/fpsyg.2026.1862222 [doi] LID - 1862222 AB - BACKGROUND: Physical activity is consistently associated with reduced anxiety in adolescents, yet the psychological mechanisms underlying this association remain unclear. This study examined whether resilience and self-efficacy independently and sequentially mediated the association between physical activity and social anxiety. METHODS: A cross-sectional design was used with 986 Chinese adolescents. Physical activity, resilience, self-efficacy, and social anxiety were assessed using validated scales (PARS-3, CD-RISC, GSES, and SASC). Structural equation modeling was conducted in R, and indirect effects were tested using bias-corrected bootstrap procedures with 5,000 resamples. RESULTS: Physical activity was significantly associated with lower social anxiety both directly (beta = -0.420, p < 0.001) and indirectly. The indirect association through resilience was significant [beta = -0.049, 95% CI [-0.064, -0.035]], whereas the indirect effect through self-efficacy and the serial mediation pathway were not significant. Absolute fit indices were acceptable (RMSEA = 0.064, SRMR = 0.073), but the incremental fit indices fell below conventional thresholds (CFI = 0.805, TLI = 0.796); the structural estimates should therefore be interpreted with corresponding caution. CONCLUSIONS: These findings are consistent with a model in which resilience functions as a proximal correlate linking physical activity to lower social anxiety, whereas general self-efficacy did not emerge as a significant mediator in this cross-sectional sample. Given the study design and the modest incremental fit of the model, these pathways should be read as theoretically plausible associations rather than causal effects. The results nonetheless underscore the potential value of fostering resilience within physical activity interventions, and they identify longitudinal designs and domain-specific efficacy measures as priorities for future research. CI - Copyright (c) 2026 Wang, Chen, Li, Yang, Chen, Shi, Lv and Lipowski. FAU - Wang, Ning AU - Wang N AD - Department of Physical Education, Lanzhou Institute of Technology, Lanzhou, Gansu, China. FAU - Chen, Ye AU - Chen Y AD - School of Business, China West Normal University, Nanchong, China. FAU - Li, Mengmeng AU - Li M AD - Chongqing Metropolitan College of Science and Technology, Chongqing, China. FAU - Yang, Jifan AU - Yang J AD - Jinding First Primary School, Zhuhai High tech Zone, Zhuhai, China. FAU - Chen, Fangting AU - Chen F AD - Jingyang Primary School, Zhuhai High tech Zone, Zhuhai, China. FAU - Shi, Yijie AU - Shi Y AD - Gdansk University of Physical Education and Sport, Gdansk, Poland. FAU - Lv, Rujun AU - Lv R AD - Zhongshan University Affiliated Houhuan Primary School in the High-tech Zone of Zhuhai City, Zhuhai, China. FAU - Lipowski, Mariusz AU - Lipowski M AD - WSB Merito University in Gdansk, Gdansk, Poland. LA - eng PT - Journal Article DEP - 20260818 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13529522 OTO - NOTNLM OT - adolescents OT - physical activity OT - resilience OT - self-efficacy OT - social anxiety COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/02 11:39 MHDA- 2026/09/02 11:40 PMCR- 2026/08/18 CRDT- 2026/09/02 05:23 PHST- 2026/04/22 00:00 [received] PHST- 2026/07/17 00:00 [revised] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/09/02 11:40 [medline] PHST- 2026/09/02 11:39 [pubmed] PHST- 2026/09/02 05:23 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1862222 [doi] PST - epublish SO - Front Psychol. 2026 Aug 18;17:1862222. doi: 10.3389/fpsyg.2026.1862222. eCollection 2026. PMID- 42680256 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260901 IS - 1938-3207 (Electronic) IS - 0002-9165 (Linking) VI - 124 IP - 3 DP - 2026 Sep TI - Low-burden metrics for monitoring healthy diets among nonpregnant females aged 15 to 49 years: a multicountry validation analysis using quantitative 24-hour dietary intake data. PG - 101387 LID - S0002-9165(26)00196-6 [pii] LID - 10.1016/j.ajcnut.2026.101387 [doi] AB - BACKGROUND: Limited nationally representative quantitative dietary intake data and a lack of consensus on lower-burden tools and metrics hinder high-frequency monitoring of healthy diets globally. OBJECTIVES: This study aimed to evaluate the comparative construct validity and potential complementarity of low-burden metrics of a healthy diet among nonpregnant females aged 15 to 49 y. METHODS: Quantitative 24-h dietary intake data collected from 77,118 adolescent and adult females across 27 countries were used to construct low-burden metrics and reference metrics of dietary intake. Associations between mean-standardized low-burden measures or indicators and reference metrics were assessed using linear and logistic mixed-effect models, with Spearman's rho used for survey-level rank correlations. Test characteristics identified low-burden indicators best differentiated adherence to reference indicators. RESULTS: An indicator reflecting nonconsumption of sweet foods and/or sweet beverages was most robustly associated with greater adherence to <10% energy from free sugars in upper-middle-income countries odds ratio [OR] [95% confidence interval (CI)]: 5.35 [5.05, 5.66]. Food group diversity score (FGDS) was most strongly associated with and differentiated higher mean adequacy ratio of micronutrients [beta of 1-standard deviation (SD) change: approximately 11 percentage points (9, 12); rho: 0.79], whereas noncommunicable disease-Protect score best reflected consumption of >/=400 g/d of fruits and vegetables [range OR of 1-SD changes (95% CI): 2.56-3.01 (2.40, 3.13) in lower-middle and high-income countries, respectively; rho: 0.56]. FGDS and Global Diet Quality Score Positive were most consistently associated with achieving >/=25 g/d of fiber and >/=3510 mg/d of potassium across contexts. CONCLUSIONS: Low-burden data collection tools yield valid metrics, enabling high-frequency monitoring of healthy diets across contexts. Specifically, avoiding sweet foods and/or sweet beverages is an indicator for adherence to WHO free sugar guidelines among nonpregnant females in upper-middle-income countries, whereas metrics reflecting nutritious food group diversity strongly reflect better micronutrient adequacy and adherence to WHO guidelines for fruits and vegetables, fiber, and potassium intakes within and across contexts. CI - Copyright (c) 2026 Food and Agriculture Organization of the United Nations,. Published by Elsevier Inc. All rights reserved. FAU - Hanley-Cook, Giles T AU - Hanley-Cook GT AD - Food and Nutrition Division, Food and Agriculture Organization of the United Nations, Rome, Italy. Electronic address: giles.hanleycook@fao.org. FAU - Frongillo, Edward A AU - Frongillo EA AD - Department of Health Promotion, Education, and Behaviour, Arnold School of Public Health, University of South Carolina, Columbia, SC, United States. FAU - Sattamini, Isabela Fleury AU - Sattamini IF AD - Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland. FAU - Ingenbleek, Luc AU - Ingenbleek L AD - Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland. FAU - Coates, Jennifer C AU - Coates JC AD - The Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, United States. FAU - Holmes, Bridget A AU - Holmes BA AD - Food and Nutrition Division, Food and Agriculture Organization of the United Nations, Rome, Italy. CN - Healthy Diets Monitoring Initiative (HDMI) LA - eng PT - Journal Article PT - Validation Study DEP - 20260813 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Humans MH - Female MH - *Diet, Healthy MH - Adolescent MH - Adult MH - Young Adult MH - Middle Aged MH - Energy Intake MH - Diet Surveys OTO - NOTNLM OT - GDQS OT - MDD-W OT - UPF OT - construct validity OT - dietary diversity OT - healthy diets OT - macronutrient balance OT - moderation OT - monitoring OT - nutrient adequacy COIS- Conflict of interest EF is a member of the Statistical Review Board of the American Society for Nutrition. The authors report no conflicts of interest. FIR - Aguayo, Victor IR - Aguayo V IRAD- Data and Analytics Section, Division of Data, Analytics, Planning and Monitoring, United Nations Children's Fund, New York, NY, United States. FIR - Branca, Francesco IR - Branca F IRAD- Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland. FIR - Borghi, Elaine IR - Borghi E IRAD- Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland. FIR - Coates, Jennifer C IR - Coates JC IRAD- The Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, United States. FIR - Frongillo, Edward A IR - Frongillo EA IRAD- Department of Health Promotion, Education, and Behaviour, Arnold School of Public Health, University of South Carolina, Columbia, SC, United States. FIR - Hanley-Cook, Giles T IR - Hanley-Cook GT IRAD- Food and Nutrition Division, Food and Agriculture Organization of the United Nations, Rome, Italy. FIR - Hassfurter, Karoline IR - Hassfurter K IRAD- Data and Analytics Section, Division of Data, Analytics, Planning and Monitoring, United Nations Children's Fund, New York, NY, United States. FIR - Hayashi, Chika IR - Hayashi C IRAD- Data and Analytics Section, Division of Data, Analytics, Planning and Monitoring, United Nations Children's Fund, New York, NY, United States. FIR - Holmes, Bridget A IR - Holmes BA IRAD- Food and Nutrition Division, Food and Agriculture Organization of the United Nations, Rome, Italy. FIR - Ingenbleek, Luc IR - Ingenbleek L IRAD- Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland. FIR - Mehra, Vrinda IR - Mehra V IRAD- Data and Analytics Section, Division of Data, Analytics, Planning and Monitoring, United Nations Children's Fund, New York, NY, United States. FIR - Neufeld, Lynnette M IR - Neufeld LM IRAD- Food and Nutrition Division, Food and Agriculture Organization of the United Nations, Rome, Italy. FIR - Saha, Kuntal IR - Saha K IRAD- Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland. FIR - Sattamini, Isabella Fleury IR - Sattamini IF IRAD- Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland. EDAT- 2026/09/01 23:34 MHDA- 2026/09/01 23:35 CRDT- 2026/09/01 20:54 PHST- 2025/09/08 00:00 [received] PHST- 2026/04/14 00:00 [revised] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/09/01 23:35 [medline] PHST- 2026/09/01 23:34 [pubmed] PHST- 2026/09/01 20:54 [entrez] AID - S0002-9165(26)00196-6 [pii] AID - 10.1016/j.ajcnut.2026.101387 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Sep;124(3):101387. doi: 10.1016/j.ajcnut.2026.101387. Epub 2026 Aug 13. PMID- 42680155 OWN - NLM STAT- Publisher LR - 20260901 IS - 1753-4887 (Electronic) IS - 0029-6643 (Linking) DP - 2026 Sep 1 TI - Validity of Nutrition Screening Tools for Risk of Malnutrition Among Pediatric Oncology Populations: A Systematic Review and Meta-Analysis. LID - nuag120 [pii] LID - 10.1093/nutrit/nuag120 [doi] AB - CONTEXT: The lack of standardized procedures for malnutrition risk screening in the pediatric oncology population. OBJECTIVE: This systematic review and meta-analysis aimed to evaluate the validity of nutritional screening tools for identifying the risk of malnutrition in pediatric oncology patients. DATA SOURCES: A systematic review of studies identified in 4 databases (Web of Science, Scopus, OVID and CINAHL) were searched from inception to April 2025. DATA EXTRACTION: Two reviewers independently screened studies, extracted data, and assessed methodological quality using the Quality Assessment of Diagnostic Accuracy Studies 2 tool. DATA ANALYSIS: Diagnostic accuracy outcomes were analyzed using a Bayesian bivariate random-effects model via MetaBayesDTA. Summary estimates were pooled where applicable, and summary receiver operating characteristic curves were generated to illustrate diagnostic performance. RESULTS: Of 1377 articles retrieved, 7 met inclusion criteria for the systematic review, and 6 were included in the pooled meta-analysis. These studies evaluated 4 different nutrition screening tools, including the Screening Tool for Childhood Cancer (SCAN), Screening Tool for Risk on Nutritional Status and Growth (STRONGkids), Pediatric Yorkhill Malnutrition Score (PYMS), and Screening Tool for the Assessment of Malnutrition in Pediatrics (STAMP). The meta-analysis evaluated the diagnostic performance of 3 nutritional risk screening tools-SCAN, STRONGkids, and PYMS-against anthropometric measurements and/or pediatric Subjective Global Nutritional Assessment (SGNA) as reference standards. SCAN demonstrated good to excellent sensitivity against body mass index (BMI; 89.0%; 95% CrI, 68.8-95.9) and SGNA (95.0%; 95% CrI, 72.9-98.9), though with poor to insufficient specificity. PYMS showed excellent sensitivity (91.0%; 95% CrI, 59.1-97.8), but poor specificity (43.3%; 95% CrI, 26.1-66.6) compared to BMI. CONCLUSION: SCAN and PYMS demonstrated high sensitivity but low specificity in identifying pediatric cancer patients at risk of malnutrition. Future research should focus on validation studies, aimed at standardizing the nutritional risk screening process in the pediatric oncology population. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration No. [CRD420251022898]. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the International Life Sciences Institute. FAU - Kangalgil, Melda AU - Kangalgil M AUID- ORCID: 0000-0003-2868-8903 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Sivas Cumhuriyet University, Sivas, 58140, Turkiye. FAU - Meral, Buket AU - Meral B AUID- ORCID: 0000-0003-1664-9333 AD - Department of Child Health and Diseases Nursing, Faculty of Health Sciences, Karadeniz Technical University, Trabzon, 61080, Turkiye. FAU - Kucuk Erdol, Ebru AU - Kucuk Erdol E AUID- ORCID: 0000-0003-1182-7807 AD - Department of Obstetrics and Gynecology Nursing, Faculty of Health Sciences, Karadeniz Technical University, Trabzon, 61080, Turkiye. LA - eng PT - Journal Article DEP - 20260901 PL - United States TA - Nutr Rev JT - Nutrition reviews JID - 0376405 SB - IM OTO - NOTNLM OT - cancer OT - child OT - malnutrition OT - malnutrition screening tools OT - meta-analysis OT - nutritional screening EDAT- 2026/09/01 23:34 MHDA- 2026/09/01 23:34 CRDT- 2026/09/01 19:53 PHST- 2026/09/01 23:34 [medline] PHST- 2026/09/01 23:34 [pubmed] PHST- 2026/09/01 19:53 [entrez] AID - 8778819 [pii] AID - 10.1093/nutrit/nuag120 [doi] PST - aheadofprint SO - Nutr Rev. 2026 Sep 1:nuag120. doi: 10.1093/nutrit/nuag120. PMID- 42676515 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260902 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - Early and sex-specific dynamic changes of the modified Glasgow Prognostic Score correlate with survival and immunotoxicities in patients undergoing allogeneic hematopoietic stem cell transplantation. PG - 1894926 LID - 10.3389/fimmu.2026.1894926 [doi] LID - 1894926 AB - Risk assessment before allogeneic hematopoietic stem cell transplantation (alloHSCT) is essential to estimate treatment-related morbidity and mortality; the hematopoietic cell transplantation-comorbidity index (HCT-CI) is widely used. The modified Glasgow Prognostic Score (mGPS), reflecting systemic inflammation and nutritional status, is a validated prognostic marker in solid tumors, but ill-defined in alloHSCT. We evaluated the prognostic impact of mGPS before and early after alloHSCT on overall survival (OS), non-relapse mortality (NRM), and acute graft-versus-host disease (aGvHD). We analyzed 442 consecutive alloHSCT patients (2012-2017, University Hospital Cologne). Outcomes were assessed by mGPS pre-transplant (preTx), at day+30, and by dynamic changes (Delta(30)mGPS). Subgroup analyses included transplant characteristics and sex. Patients with mGPS 2 preTx had inferior OS (HR 2.32, p<0.0001) and NRM (HR 2.31, p=0.002). Moreover, Delta(30)mGPS changes indicated poorer OS and NRM rates more strongly (Delta(30)mGPS(1-->2vs0-->1): OS: HR 2.85, p=0.02; NRM: HR 3.99, p=0.05). Findings regarding aGvHD were conflicting. Multivariable analysis confirmed mGPS as an independent prognostic factor for survival. Sex-specific analyses revealed distinct risk patterns. These findings highlight the prognostic relevance of the immunonutritional status before and early after alloHSCT, warranting prospective studies to further validate the mGPS for refined risk stratification. CI - Copyright (c) 2026 Thurisch, Althoff, Leuchte, Shahbaz, Funk, Kirmaier, Hadzic, Oganesian, Carboniero, Vona, Geier, Muschik, Cordas dos Santos, von Bergwelt-Baildon, Holtick, Scheid and Theurich. FAU - Thurisch, Hannah AU - Thurisch H AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. AD - German Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany. AD - Bavarian Cancer Research Center (BZKF), LMU University Hospital, Munich, Germany. FAU - Althoff, Kathrin C AU - Althoff KC AD - Department I of Internal Medicine, Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany. AD - Department of Otorhinolaryngology, University of Lubeck, Lubeck, Germany. FAU - Leuchte, Katharina AU - Leuchte K AD - Department I of Internal Medicine, Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany. AD - National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark. FAU - Shahbaz, Wajma AU - Shahbaz W AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - Funk, Maximilian A AU - Funk MA AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. AD - German Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany. AD - Bavarian Cancer Research Center (BZKF), LMU University Hospital, Munich, Germany. FAU - Kirmaier, Martin E AU - Kirmaier ME AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - Hadzic, Amar AU - Hadzic A AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - Oganesian, Sabine AU - Oganesian S AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - Carboniero, Adriano AU - Carboniero A AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. AD - German Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany. FAU - Vona, Ludovica AU - Vona L AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - Geier, Caroline AU - Geier C AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - Muschik, Lena AU - Muschik L AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - Cordas Dos Santos, David M AU - Cordas Dos Santos DM AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - von Bergwelt-Baildon, Michael AU - von Bergwelt-Baildon M AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. AD - German Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany. AD - Bavarian Cancer Research Center (BZKF), LMU University Hospital, Munich, Germany. FAU - Holtick, Udo AU - Holtick U AD - Department I of Internal Medicine, Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany. FAU - Scheid, Christof AU - Scheid C AD - Department I of Internal Medicine, Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany. FAU - Theurich, Sebastian AU - Theurich S AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. AD - German Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany. AD - Bavarian Cancer Research Center (BZKF), LMU University Hospital, Munich, Germany. LA - eng PT - Journal Article DEP - 20260817 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 SB - IM MH - Humans MH - *Hematopoietic Stem Cell Transplantation/adverse effects/mortality MH - Male MH - Female MH - *Graft vs Host Disease/etiology/mortality MH - Middle Aged MH - Adult MH - Prognosis MH - Transplantation, Homologous MH - Sex Factors MH - Young Adult MH - Adolescent MH - Risk Assessment MH - Aged MH - Retrospective Studies PMC - PMC13526978 OTO - NOTNLM OT - allogeneic hematopoietic stem cell transplantation OT - graft-versus-host disease OT - immunonutritional status OT - inflammation OT - metabolism OT - risk assessment COIS- The authors declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author ST declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/09/01 11:39 MHDA- 2026/09/01 11:40 PMCR- 2026/08/17 CRDT- 2026/09/01 05:22 PHST- 2026/05/29 00:00 [received] PHST- 2026/07/25 00:00 [revised] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/09/01 11:40 [medline] PHST- 2026/09/01 11:39 [pubmed] PHST- 2026/09/01 05:22 [entrez] PHST- 2026/08/17 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1894926 [doi] PST - epublish SO - Front Immunol. 2026 Aug 17;17:1894926. doi: 10.3389/fimmu.2026.1894926. eCollection 2026. PMID- 42675825 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260907 IS - 1643-3750 (Electronic) IS - 1234-1010 (Print) IS - 1234-1010 (Linking) VI - 32 DP - 2026 Sep 1 TI - Development and Clinical Feasibility of a Computer-Assisted Shape Design and Bending System for Spinal Fixation Rods. PG - e952722 LID - 10.12659/MSM.952722 [doi] LID - e952722 AB - BACKGROUND Spinal pedicle screw-rod fixation is widely used, but manual rod bending is time-consuming and prone to contour inconsistencies. Although computer-assisted technologies have been explored, existing systems remain limited by cost, complexity, and insufficient precision. This study evaluated a novel computer-assisted rod design and bending system, with the goal of testing whether computer-assisted rod bending reduces bending plus installation time vs manual bending in unilateral paired cases and to evaluate safety, feasibility, and rod-screw fitting accuracy. MATERIAL AND METHODS A prospective trial enrolled 26 patients (18-75 years) undergoing spinal pedicle screw-rod fixation (>/=4 segments) for fractures or degenerative diseases. Twenty patients received unilateral computer-assisted bending (contralateral manual for comparison) and 6 received bilateral assisted bending. The primary outcome was bending plus installation time; secondary outcomes included complications and fitting accuracy. Wilcoxon signed-rank test was used (P<0.05). RESULTS No instrument-related complications were observed (n=26; median age 60.5 years). For 20 unilateral cases, computer-assisted bending (183.3+/-70.8 seconds) was significantly shorter than manual bending (236.1+/-119.1 s; mean reduction 52.75 seconds, P=0.017). Subgroup analyses indicated signals of greater time savings in more than 4 segments (93.9 seconds, P=0.039) and BMI of 25 kg/m2 or higher (95.3 seconds, P=0.005), although these were exploratory and not adjusted for multiplicity. CONCLUSIONS The computer-assisted system reduced bending plus installation time vs manual bending, with no instrument-related complications. Subgroup findings were exploratory and require further validation. FAU - Li, Xingye AU - Li X AD - Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China. FAU - Zhang, Weijun AU - Zhang W AUID- ORCID: 0009-0000-0688-4036 AD - School of Medical Science and Engineering, Beijing Institute of Technology, Beijing, China. AD - TINAVI Medical Technologies Co., Ltd., Beijing, China. FAU - Xu, Zhongning AU - Xu Z AD - Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China. FAU - Zhao, Yongqiang AU - Zhao Y AD - TINAVI Medical Technologies Co., Ltd., Beijing, China. FAU - An, Yan AU - An Y AD - Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China. FAU - Li, Qingyun AU - Li Q AD - Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China. FAU - He, Da AU - He D AD - Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China. LA - eng PT - Journal Article DEP - 20260901 PL - United States TA - Med Sci Monit JT - Medical science monitor : international medical journal of experimental and clinical research JID - 9609063 SB - IM MH - Humans MH - Middle Aged MH - Female MH - Adult MH - Prospective Studies MH - Aged MH - Male MH - Adolescent MH - Pedicle Screws MH - Feasibility Studies MH - *Computer-Aided Design MH - *Fracture Fixation, Internal/methods/instrumentation MH - Young Adult MH - *Spinal Fusion/methods/instrumentation MH - *Surgery, Computer-Assisted/methods PMC - PMC13545973 COIS- Conflict of interest: None declared EDAT- 2026/09/01 05:41 MHDA- 2026/09/01 05:42 PMCR- 2026/09/01 CRDT- 2026/09/01 01:23 PHST- 2026/09/01 05:42 [medline] PHST- 2026/09/01 05:41 [pubmed] PHST- 2026/09/01 01:23 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - 952722 [pii] AID - 10.12659/MSM.952722 [doi] PST - epublish SO - Med Sci Monit. 2026 Sep 1;32:e952722. doi: 10.12659/MSM.952722. PMID- 42675564 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260903 IS - 1932-846X (Electronic) IS - 1932-8451 (Print) IS - 1932-8451 (Linking) VI - 86 IP - 4 DP - 2026 Oct TI - Does the Gut Microbiota Play a Role in Attention-Deficit/Hyperactivity Disorder in Childhood? A Pilot Study From Turkey. PG - e70057 LID - 10.1002/dneu.70057 [doi] LID - e70057 AB - The pathophysiology of attention-deficit/hyperactivity disorder (ADHD) is not fully understood, but increasing evidence suggests that gut microbiota may play a role. This study compared the gut microbiota of children with ADHD with that of a control group of healthy children, and examined their dietary and sleep habits. Ten medication-naive children aged 612 years who had recently been diagnosed with ADHD and ten healthy controls were included. ADHD diagnoses were confirmed using the Schedule for Affective Disorders and Schizophrenia for School-Age ChildrenPresent and Lifetime Version (K-SADS-PL). Sleep and eating habits were assessed using the 2nd Level Sleep Disorder Short Form, the Children's Eating Behaviour Inventory, and a form to collect sociodemographic and clinical information. The gut microbiota were analysed using 16S NGS metagenome analysis. A significant decrease in the Shannon and Simpson diversity index values was observed in the ADHD group compared to the control group. Despite the presence of a percentage difference, no statistically significant differences were observed between the groups with respect to species, genus, family, order, class or phylum. Following evaluation of the sleep and eating habit scale scores, no statistically significant difference between the groups was determined.These findings suggests that children with ADHD may alter gut microbiota diversity.However, the absence of significant taxonomic differences and the small sample size mean that these results should be interpreted with caution. Further, larger, adequately powered studies are needed to validate these findings and clarify the potential role of gut microbiota in the pathophysiology of ADHD. CI - (c) 2026 Wiley Periodicals LLC. FAU - Akyol, Cansin Kardelen AU - Akyol CK AUID- ORCID: 0000-0002-8772-3476 AD - Department of Child and Adolescent Psychiatry, Akhisar State Hospital, Manisa, Turkey. FAU - Bilac, Oznur AU - Bilac O AUID- ORCID: 0000-0001-8369-6215 AD - Department of Child and Adolescent Psychiatry, Manisa Celal Bayar University, Manisa, Turkey. FAU - Cam, Fethi Sirri AU - Cam FS AUID- ORCID: 0000-0002-0972-8896 AD - Department of Medical Genetics, Manisa Celal Bayar University, Manisa, Turkey. LA - eng GR - 2022-146/Manisa Celal Bayar University Scientific Research Projects Coordination Unit/ PT - Journal Article PL - United States TA - Dev Neurobiol JT - Developmental neurobiology JID - 101300215 SB - IM MH - Humans MH - *Attention Deficit Disorder with Hyperactivity/microbiology/physiopathology MH - Male MH - Pilot Projects MH - *Gastrointestinal Microbiome/physiology MH - Turkey MH - Female MH - Child MH - Feeding Behavior/physiology MH - Sleep/physiology PMC - PMC13530312 OTO - NOTNLM OT - Attention-deficit/hyperactivity disorder (ADHD) OT - gut microbiota OT - hyperactivity OT - impulsivity OT - inattention OT - neurodevelopmental disorder COIS- The authors declare no conflicts of interest. EDAT- 2026/09/01 05:41 MHDA- 2026/09/01 05:42 PMCR- 2026/09/01 CRDT- 2026/09/01 00:13 PHST- 2026/07/10 00:00 [revised] PHST- 2026/02/20 00:00 [received] PHST- 2026/07/28 00:00 [accepted] PHST- 2026/09/01 05:42 [medline] PHST- 2026/09/01 05:41 [pubmed] PHST- 2026/09/01 00:13 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - DNEU70057 [pii] AID - 10.1002/dneu.70057 [doi] PST - ppublish SO - Dev Neurobiol. 2026 Oct;86(4):e70057. doi: 10.1002/dneu.70057. PMID- 42674753 OWN - NLM STAT- MEDLINE DCOM- 20260831 LR - 20260930 IS - 1532-656X (Electronic) IS - 0891-5245 (Linking) VI - 40 IP - 5 DP - 2026 Sep-Oct TI - Beyond "Picky Eating": Identification, Screening, and Referral for Pediatric Feeding Disorders in Primary Care. PG - 770-781 LID - S0891-5245(26)00129-X [pii] LID - 10.1016/j.pedhc.2026.05.011 [doi] AB - Pediatric feeding disorders (PFDs) affect 1 in 37 children under age 5 in the United States, representing a common yet frequently underrecognized condition in primary care. In 2019, a multidisciplinary expert panel established the first consensus definition of PFD, creating a standardized four-domain framework (medical, nutritional, feeding skill, and psychosocial) that has transformed clinical assessment and management. A recent 2025 consensus further clarified the relationship between PFD and avoidant/restrictive food intake disorder (ARFID), providing guidance on diagnostic overlap and differentiation. This continuing education article provides pediatric healthcare providers with current, evidence-based knowledge to screen, identify, and make appropriate referrals for children with PFDs. The article reviews the consensus definitions, epidemiology, validated screening tools, differential diagnosis, risk factors, assessment strategies, and referral guidelines. A case-based example illustrates the application of the four-domain framework in clinical practice. With appropriate early identification and intervention, most children with feeding difficulties can achieve improved nutritional status, oral-motor development, and positive mealtime experiences. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Taha, Asma A AU - Taha AA AD - School of Nursing, California State University, Fullerton, CA; Child Development and Rehabilitation Center (CDRC), School of Medicine, Oregon Health & Science University, Portland, OR. Electronic address: ataha@fullerton.edu. FAU - Sahl, Sarah F AU - Sahl SF AD - Child Development and Rehabilitation Center (CDRC), School of Medicine, Oregon Health & Science University, Portland, OR. FAU - Farrell, Julia R AU - Farrell JR AD - Child Development and Rehabilitation Center (CDRC), School of Medicine, Oregon Health & Science University, Portland, OR. FAU - Wright, Amber AU - Wright A AD - Child Development and Rehabilitation Center (CDRC), School of Medicine, Oregon Health & Science University, Portland, OR. FAU - Frazier, Kelsey AU - Frazier K AD - Child Development and Rehabilitation Center (CDRC), School of Medicine, Oregon Health & Science University, Portland, OR. FAU - Doan, Sylvia AU - Doan S AD - Child Development and Rehabilitation Center (CDRC), School of Medicine, Oregon Health & Science University, Portland, OR; Division of Gastroenterology, Department of Pediatrics, School of Medicine, Oregon Health & Science University, Portland, OR. LA - eng PT - Journal Article PT - Review PL - United States TA - J Pediatr Health Care JT - Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners JID - 8709735 SB - IM MH - Child, Preschool MH - Humans MH - Infant MH - Avoidant Restrictive Food Intake Disorder MH - Diagnosis, Differential MH - *Feeding and Eating Disorders/diagnosis MH - *Feeding and Eating Disorders of Childhood/diagnosis/therapy/epidemiology MH - *Mass Screening/methods MH - Practice Guidelines as Topic MH - *Primary Health Care MH - *Referral and Consultation MH - Risk Factors MH - United States/epidemiology OTO - NOTNLM OT - Avoidant/restrictive food intake disorder (ARFID) OT - Multidisciplinary assessment OT - Pediatric feeding disorder (PFD) OT - Pediatric primary care OT - Screening and early identification COIS- CONFLICTS OF INTEREST None to report. EDAT- 2026/08/31 23:43 MHDA- 2026/08/31 23:44 CRDT- 2026/08/31 20:54 PHST- 2026/02/13 00:00 [received] PHST- 2026/03/27 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/08/31 23:44 [medline] PHST- 2026/08/31 23:43 [pubmed] PHST- 2026/08/31 20:54 [entrez] AID - S0891-5245(26)00129-X [pii] AID - 10.1016/j.pedhc.2026.05.011 [doi] PST - ppublish SO - J Pediatr Health Care. 2026 Sep-Oct;40(5):770-781. doi: 10.1016/j.pedhc.2026.05.011. PMID- 42674301 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20261028 IS - 1573-2517 (Electronic) IS - 0165-0327 (Linking) VI - 415 DP - 2026 Dec 15 TI - Emotion regulation and state body image during daily body-exposure situations: A pilot ecological momentary assessment study. PG - 122447 LID - S0165-0327(26)01300-5 [pii] LID - 10.1016/j.jad.2026.122447 [doi] AB - BACKGROUND: Emotion regulation has been consistently associated with eating disorder psychopathology, yet most evidence comes from retrospective and cross-sectional studies. Ecological momentary assessment (EMA) allows these processes to be examined as they unfold during daily body-exposure situations. This pilot study investigated associations among emotion regulation strategies, affect, and state body image during naturally occurring body-exposure situations and explored whether average regulatory patterns across a two-week EMA period were associated with short-term change in drive for thinness. METHOD: Thirty-four young adults completed a 14-day EMA protocol combining event-based and end-of-day assessments. Event-level measures included state body image, positive and negative affect, cognitive reappraisal, expressive suppression, and rumination. Drive for thinness was assessed at baseline and post-monitoring. Pearson correlations examined associations among participant-level averages, a linear mixed-effects model tested event-level associations, and multiple regression examined whether average emotion regulation variables were associated with post-monitoring drive for thinness after controlling for baseline scores. RESULTS: Participants completed 305 EMA entries, corresponding to 64.08% adherence. More positive average body image was associated with higher positive affect and lower negative affect, expressive suppression, and rumination. At the event level, greater expressive suppression and rumination were associated with poorer state body image, whereas cognitive reappraisal was not. Baseline drive for thinness was significantly associated with post-monitoring scores. None of the EMA-derived emotion regulation variables was significantly associated with post-monitoring drive for thinness after controlling for baseline levels. DISCUSSION: These preliminary findings suggest that expressive suppression and rumination may co-occur with poorer state body image during everyday body-salient situations. Larger EMA studies using parallel and validated measures of emotion regulation are needed to clarify these associations and their temporal relevance. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Rojas-Rincon, Juliana AU - Rojas-Rincon J AD - BrainXR Lab, Department of Psychology, Universitat Internacional de Catalunya, 08195, Sant Cugat del Valles, Spain. FAU - Gamiz-Sanfeliu, Maria AU - Gamiz-Sanfeliu M AD - BrainXR Lab, Department of Psychology, Universitat Internacional de Catalunya, 08195, Sant Cugat del Valles, Spain. FAU - Ampatzoglou, Aikaterini AU - Ampatzoglou A AD - BrainXR Lab, Department of Psychology, Universitat Internacional de Catalunya, 08195, Sant Cugat del Valles, Spain. FAU - Carballo-Marquez, Anna AU - Carballo-Marquez A AD - BrainXR Lab, Department of Psychology, Universitat Internacional de Catalunya, 08195, Sant Cugat del Valles, Spain. FAU - Garolera, Maite AU - Garolera M AD - BrainXR Lab, Department of Psychology, Universitat Internacional de Catalunya, 08195, Sant Cugat del Valles, Spain; Brain, Cognition, and Behavior Research Group, Consorci Sanitari de Terrassa-Hospital Universitari, 08227, Terrassa, Spain. FAU - Fernandez-Capo, Maria AU - Fernandez-Capo M AD - BrainXR Lab, Department of Psychology, Universitat Internacional de Catalunya, 08195, Sant Cugat del Valles, Spain. FAU - Porras-Garcia, Bruno AU - Porras-Garcia B AD - BrainXR Lab, Department of Psychology, Universitat Internacional de Catalunya, 08195, Sant Cugat del Valles, Spain; Brain, Cognition, and Behavior Research Group, Consorci Sanitari de Terrassa-Hospital Universitari, 08227, Terrassa, Spain. Electronic address: bporras@uic.es. LA - eng PT - Journal Article DEP - 20260901 PL - Netherlands TA - J Affect Disord JT - Journal of affective disorders JID - 7906073 SB - IM EIN - J Affect Disord. 2026 Oct 28:122659. doi: 10.1016/j.jad.2026.122659. PMID: 42951731 MH - Humans MH - *Emotional Regulation MH - *Ecological Momentary Assessment MH - Pilot Projects MH - *Body Image/psychology MH - Female MH - Male MH - Young Adult MH - Rumination, Cognitive MH - Affect MH - Adult MH - Thinness/psychology MH - Adolescent OTO - NOTNLM OT - Affect OT - Body image OT - Eating disorders OT - Ecological momentary assessment OT - Emotion regulation OT - Prevention OT - Rumination OT - Suppression COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/31 23:43 MHDA- 2026/09/25 23:47 CRDT- 2026/08/31 19:14 PHST- 2026/05/13 00:00 [received] PHST- 2026/07/30 00:00 [revised] PHST- 2026/08/29 00:00 [accepted] PHST- 2026/09/25 23:47 [medline] PHST- 2026/08/31 23:43 [pubmed] PHST- 2026/08/31 19:14 [entrez] AID - S0165-0327(26)01300-5 [pii] AID - 10.1016/j.jad.2026.122447 [doi] PST - ppublish SO - J Affect Disord. 2026 Dec 15;415:122447. doi: 10.1016/j.jad.2026.122447. Epub 2026 Sep 1. PMID- 42673582 OWN - NLM STAT- MEDLINE DCOM- 20260831 LR - 20260917 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Aug 31 TI - Remote Assessment of Physical Function and Physical Activity in Adults With Autism Spectrum Disorder: Protocol for Feasibility, Validity, and Reliability Study. PG - e86020 LID - 10.2196/86020 [doi] LID - e86020 AB - BACKGROUND: Adults with autism spectrum disorder (ASD) are at increased risk for chronic health conditions and reduced quality of life (QoL), often linked to lower physical activity (PA), motor impairments, and barriers to health care access. Although communication and social differences in ASD are well documented, motor impairments such as deficits in coordination, balance, and gait remain understudied in adulthood despite their relevance to fall risk and PA participation. Telehealth and wearable technologies may improve access to physical therapy assessment and remote monitoring of physical function in this underserved population. OBJECTIVE: This pilot study aims to evaluate the feasibility, construct validity, and rating reliability of remotely administered physical function and balance assessments in adults with ASD and to examine racial and ethnic disparities and associations among physical function, PA, fall risk, and QoL. METHODS: This pilot study uses a 2-phase, cross-sectional, noninterventional design with remote data collection in legally independent adults aged 18-59 years with ASD who were recruited through the Simons Powering Autism Research and Knowledge (SPARK) registry. Participants complete self-report questionnaires; 2 weeks of wearable step monitoring using a Fitbit Inspire 3 (Google LLC) device; and, for a randomized subset of 25 participants, 1 remote, telehealth-based physical function assessment session. Remote performance-based measures include the Five Times Sit-to-Stand, 30-second Sit-to-Stand, standing balance under eyes open and eyes closed conditions, and single-leg stance under eyes open and eyes closed conditions. Construct validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) physical function measures will be examined using hypothesis testing with related indicators of health and functioning, including steps per day, lower-extremity functional outcome surveys, fall risk screening surveys, and comorbidity burden. Interrater and intrarater reliability of remote performance scoring will be evaluated from video-recorded sessions scored by 6 raters using intraclass correlation coefficients. Secondary analyses will examine racial and ethnic disparities in physical function, PA, and QoL, as well as associations among these variables and moderation by race and ethnicity. RESULTS: Study funding was available from August 2024 to May 2025. Recruitment occurred from December 2024 to March 2025, and final data collection was completed in May 2025. By May 2025, 155 adults with ASD had been recruited, of whom 65.2% were female and 77% identified as Black or Hispanic. Data analysis is projected to be completed in July 2026, and submission of the primary results manuscript is anticipated in August 2026. CONCLUSIONS: This protocol describes a pilot study designed to evaluate the feasibility, construct validity, and equity relevance of remotely administered physical function assessments in adults with ASD. If supported, the findings may provide preliminary evidence for more accessible telehealth-based assessment approaches and inform larger studies on physical functioning, PA, and QoL in this population. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/86020. CI - (c)Annabel Nunez-Gaunaurd, Melissa M Tovin, Melissa Hale, Tan Li, Anjana Bhat. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 31.08.2026. FAU - Nunez-Gaunaurd, Annabel AU - Nunez-Gaunaurd A AUID- ORCID: 0000-0002-2977-7994 AD - Department of Physical Therapy, Nicole Wertheim College of Nursing & Health Sciences, Florida International University, Miami, FL, United States. FAU - Tovin, Melissa M AU - Tovin MM AUID- ORCID: 0000-0003-1355-3117 AD - Department of Physical Therapy, Miller School of Medicine, University of Miami, Miami, FL, United States. FAU - Hale, Melissa AU - Hale M AUID- ORCID: 0000-0001-5963-4794 AD - Division Director, Child and Family Services, College of Arts and Sciences, University of Miami, Miami, FL, United States. FAU - Li, Tan AU - Li T AUID- ORCID: 0000-0001-6871-7719 AD - Department of Biostatistics, Stempel College of Public Health, Florida International University, Miami, FL, United States. FAU - Bhat, Anjana AU - Bhat A AUID- ORCID: 0000-0002-0771-0967 AD - Department of Physical Therapy, College of Health Sciences, University of Delaware, Newark, DE, United States. LA - eng GR - U54 MD012393/MD/NIMHD NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260831 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - Adult MH - Pilot Projects MH - Female MH - Feasibility Studies MH - Male MH - Reproducibility of Results MH - Middle Aged MH - *Exercise/physiology MH - Cross-Sectional Studies MH - Adolescent MH - *Autism Spectrum Disorder/physiopathology/psychology MH - Young Adult MH - Quality of Life MH - Surveys and Questionnaires MH - Telemedicine PMC - PMC13575549 OTO - NOTNLM OT - adult autism OT - autism in adulthood OT - autism spectrum disorder OT - co-participation OT - cross-sectional design OT - digital health OT - family support OT - health disparities OT - minority health OT - motor impairments OT - patient-reported outcomes OT - physical activity OT - physical function OT - protocol study OT - rehabilitation OT - remote assessment OT - telehealth OT - wearable devices COIS- Conflicts of Interest: None declared. EDAT- 2026/08/31 19:42 MHDA- 2026/08/31 23:43 PMCR- 2026/08/31 CRDT- 2026/08/31 16:53 PHST- 2025/10/16 00:00 [received] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/08/31 23:43 [medline] PHST- 2026/08/31 19:42 [pubmed] PHST- 2026/08/31 16:53 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - v15i1e86020 [pii] AID - 10.2196/86020 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Aug 31;15:e86020. doi: 10.2196/86020. PMID- 42670969 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260918 LR - 20260920 IS - 2149-2042 (Print) IS - 2149-4606 (Electronic) IS - 2149-4606 (Linking) VI - 41 IP - 3 DP - 2026 Sep 18 TI - Evaluation of Early Diagnostic Methods for Subclinical Cardiovascular Changes in Childhood Obesity. PG - 296-308 LID - 10.4274/MMJ.galenos.2026.59783 [doi] AB - Childhood obesity is associated with early cardiometabolic abnormalities and subclinical vascular and cardiac changes. This narrative review summarizes the mechanisms underlying these changes and evaluates non-invasive methods used for early detection. PubMed/MEDLINE and Scopus were searched for pediatric studies, systematic reviews, and guidelines, and the principal evidence sources were appraised using design-appropriate tools. Blood pressure measurement, anthropometry, and age-and risk-based laboratory testing remain the basis of routine assessment. Carotid intima-media thickness, pulse wave velocity, endothelial function tests, heart rate variability, advanced echocardiographic measures, and epicardial adipose tissue assessment are promising; however, methodological heterogeneity and limited pediatric reference values restrict most of them to selected clinical or research settings. Standardized longitudinal studies are required to validate thresholds and determine whether test-guided strategies improve outcomes. CI - Copyright(c) 2026 The Author(s). Published by Galenos Publishing House on behalf of Istanbul Medeniyet University Faculty of Medicine. FAU - Badem, Meryem AU - Badem M AUID- ORCID: 0000-0002-6930-2424 AD - Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Clinic of Pediatric Endocrinology, Istanbul, Turkiye. FAU - Hepokur, Merve Nur AU - Hepokur MN AUID- ORCID: 0000-0002-5470-1254 AD - Marmara University Pendik Training and Research Hospital, Department of Pediatric Cardiology, Istanbul, Turkiye. FAU - Karagozlu, Selen AU - Karagozlu S AUID- ORCID: 0000-0002-9542-1937 AD - Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Clinic of Pediatric Endocrinology, Istanbul, Turkiye. FAU - Emeksiz, Hamdi Cihan AU - Emeksiz HC AUID- ORCID: 0000-0002-4815-1591 AD - Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Clinic of Pediatric Endocrinology, Istanbul, Turkiye. LA - eng PT - Journal Article DEP - 20260831 PL - Turkey TA - Medeni Med J JT - Medeniyet medical journal JID - 101676811 PMC - PMC13586907 OTO - NOTNLM OT - Pediatric obesity OT - atherosclerosis OT - cardiovascular diagnostic techniques OT - cardiovascular diseases COIS- The authors declare that they have no conflict of interest related to this study. EDAT- 2026/08/31 19:42 MHDA- 2026/08/31 19:43 PMCR- 2026/09/18 CRDT- 2026/08/31 07:12 PHST- 2026/08/31 19:43 [medline] PHST- 2026/08/31 19:42 [pubmed] PHST- 2026/08/31 07:12 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - 10.4274/MMJ.galenos.2026.59783 [doi] PST - ppublish SO - Medeni Med J. 2026 Sep 18;41(3):296-308. doi: 10.4274/MMJ.galenos.2026.59783. Epub 2026 Aug 31. PMID- 42670657 OWN - NLM STAT- MEDLINE DCOM- 20260831 LR - 20260903 IS - 1745-5065 (Electronic) IS - 1745-5057 (Print) IS - 1745-5057 (Linking) VI - 22 DP - 2026 Jan-Dec TI - To what extent does the adapted Women's empowerment in nutrition index demonstrate psychometric validity and determine the nutritional empowerment among pregnant women in southern Ethiopia? PG - 17455057261484831 LID - 10.1177/17455057261484831 [doi] LID - 17455057261484831 AB - BackgroundWomen's empowerment plays a crucial role in the wellbeing of families by affecting nutrition and health. Women's Empowerment in Nutrition Index (WENI) was recently developed in rural South Asia, but requires validation in new contexts.ObjectiveThe study aimed to evaluate the psychometric validation of the WENI, the level of nutritional empowerment and factors associated with nutritional empowerment among pregnant women in Southern Ethiopia.DesignA facility-based cross-sectional study design was employed.MethodsThe study was conducted among 392 pregnant women from March 10 to May 30, 2025. The structural validity of the WENI was assessed using Exploratory and Confirmatory Factor Analysis (EFA/CFA) to identify latent constructs of empowerment. Kaiser-Meyer-Olkin (>/= 0.60) and significant results in Bartlett's Test (p < 0.05) were used for confirming sampling adequacy. Independent factors were identified using a hierarchical negative binomial multiple regression with adjusted incidence rate ratios (aIRRs) calculated, considering statistical significance at p < 0.05.ResultsFactor analysis revealed a six-factor structure with an internal consistency (Cronbach's alpha = 0.86), and convergent and discriminant validities (AVE=0.50, CR=0.70). The model demonstrated strong fit indices (CFI= 0.94; RMSEA<0.06). A significant relationship was found between WENI scores and maternal and child nutrition outcomes (p<0.001), with 51.5% of women being nutritionally empowered. Empowerment was higher in women free from intimate partner violence (aIRR = 1.12), those receiving nutritional counseling (aIRR = 1.33). Conversely, empowerment rates were lower in women with no formal education (aIRR = 0.76) and those in the lowest wealth quintile (aIRR = 0.82).ConclusionThis study confirmed that nutritional empowerment, measured via a 21-item tool, improves maternal health and food security. However, social norms and a "knowledge-agency gap" persist. Interventions must shift from basic education to actively promoting women's control over resources, gender equality, and stronger community-based support systems to be truly effective. FAU - Fikrie, Anteneh AU - Fikrie A AUID- ORCID: 0000-0002-9809-3326 AD - School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. RINGGOLD: 435723 FAU - Wodessa, Gelgelo AU - Wodessa G AD - School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. RINGGOLD: 435723 FAU - Gelchu, Miesa AU - Gelchu M AD - School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. RINGGOLD: 435723 FAU - Jofa, Bekam Yambo AU - Jofa BY AD - School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. RINGGOLD: 435723 FAU - Hailu, Dejene AU - Hailu D AD - School of Public Health, Hawassa University College of Medicine and Health Sciences, Awassa, Ethiopia. RINGGOLD: 293657 FAU - Abera, Mubarek AU - Abera M AD - Department of Psychiatry, Faculty of Medical Science, Jimma University, Jimma, Oromia, Ethiopia. RINGGOLD: 107839 FAU - Spigt, Mark AU - Spigt M AD - Department of Family Medicine, Universiteit Maastricht Care and Public Health Research Institute, Maastricht, Netherlands. LA - eng PT - Journal Article DEP - 20260831 PL - United States TA - Womens Health (Lond) JT - Women's health (London, England) JID - 101271249 SB - IM MH - Humans MH - Female MH - Ethiopia MH - *Psychometrics MH - Cross-Sectional Studies MH - *Empowerment MH - Adult MH - Pregnancy MH - *Pregnant People/psychology MH - Reproducibility of Results MH - *Nutritional Status MH - Surveys and Questionnaires/standards MH - Young Adult MH - *Power, Psychological MH - Rural Population PMC - PMC13530473 OAB - This study assessed how to measure nutritional empowerment, woman ability to make decisions that impact the health and nutrition of herself and her family's among 392 pregnant women in Southern Ethiopia. By using a 21-item tool called the Women's Empowerment in Nutrition Index (WENI), researchers confirmed that the survey is an accurate and reliable way to measure these capabilities in the region. The findings showed that about 51.5% of the women surveyed were nutritionally empowered, a status that was directly linked to better overall health outcomes for both mothers and children. The study identified clear factors that influence whether a woman can exercise this control. Women were significantly more likely to be empowered if they received nutritional counselling or lived in households free from intimate partner violence. Conversely, empowerment was lower among women who had no formal education or lived in the lowest income households. Ultimately, the researchers concluded that while nutritional knowledge is important, it is not enough on its own. To bridge the gap between knowing about health and having the agency to act on it, future interventions must shift focus toward promoting gender equality, securing women control over household resources, and strengthening community-based support systems. OABL- eng OTO - NOTNLM OT - factor analysis OT - pregnant women OT - psychometric validation OT - women's empowerment COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/08/31 19:42 MHDA- 2026/08/31 19:43 PMCR- 2026/08/31 CRDT- 2026/08/31 04:33 PHST- 2026/08/31 19:43 [medline] PHST- 2026/08/31 19:42 [pubmed] PHST- 2026/08/31 04:33 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - 10.1177_17455057261484831 [pii] AID - 10.1177/17455057261484831 [doi] PST - ppublish SO - Womens Health (Lond). 2026 Jan-Dec;22:17455057261484831. doi: 10.1177/17455057261484831. Epub 2026 Aug 31. PMID- 42669329 OWN - NLM STAT- Publisher LR - 20261001 IS - 2589-5559 (Electronic) IS - 2589-5559 (Linking) DP - 2026 Aug 30 TI - Clinical and Metabolomic Panel for Noninvasive Screening of Biopsy-Confirmed MASH in Children and Adolescents. PG - 102016 LID - S2589-5559(26)00287-9 [pii] LID - 10.1016/j.jhepr.2026.102016 [doi] AB - BACKGROUND & AIMS: Noninvasive tests to identify pediatric metabolic dysfunction-associated steatohepatitis (MASH) remain a critical need. We aimed to develop and validate a screening panel that identifies biopsy-confirmed MASH in children and adolescents using clinical and metabolomics data. METHODS: Fasting serum from youth in NASH CRN studies and healthy participants underwent untargeted metabolomics by liquid chromatography-mass spectrometry (LC-MS). Clinical data included anthropometrics, lipids, liver enzymes, and markers of insulin resistance. MASH was determined by biopsy in NASH CRN participants and hepatic steatosis by MRI-PDFF in healthy participants. Clinical features were selected by Kolmogorov-Smirnov testing (p < 0.05), and metabolomics data were reduced to 52 features with non-zero LASSO coefficients. Feature importance was ranked using CatBoost. The final model included eight clinical features and the top 10 annotated metabolites. Data were split into training and test sets, with longitudinal validation in a sub-cohort with 96-week follow-up biopsies. RESULTS: The cohort included 586 children (ages 5-18, 70% male, mean BMI z-score of 2.35 +/- 0.84, 72% Hispanic). Of these, 390 had MASH (21% Zone 3, 41% Zone 1, 38% definite MASH), and 196 were non-MASH. The model incorporated ALT, AST, GGT, platelets, HOMA-IR, BMI z-score, TG:HDL ratio, and alkaline phosphatase. Key metabolic features included amino acid derivatives (e.g., glutamic acid, argininosuccinic acid), indole, diacetylspermine, and lipid metabolites. The model achieved an AUROC of 0.88 (92% sensitivity, 71% specificity) in the test set and 0.81 (69% sensitivity, 86% specificity) in the longitudinal cohort. CONCLUSIONS: This 18-variable panel of eight clinical measures and 10 metabolites showed strong performance for noninvasive screening of biopsy-confirmed MASH in children and potential utility for longitudinal monitoring. IMPACT AND IMPLICATIONS: Currently, there are no clinically approved non-invasive biomarkers for diagnosing or monitoring pediatric MASH, despite its growing prevalence and long-term health risks. This study developed and validated a machine-learning-based panel that combines clinical and high-resolution metabolomics data, demonstrating strong performance for classifying MASH and monitoring disease status in a longitudinal cohort. These findings are particularly relevant for improving the care of children with MASH and could inform both clinical practice and research. With further validation, this approach could reduce reliance on liver biopsy, enable earlier detection, and support clinical decision-making for physicians and researchers. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Huneault, Helaina E AU - Huneault HE AD - Department of Pediatrics and Human Development, Michigan State University, College of Human Medicine, Grand Rapids, MI, USA; Department of Pediatrics, Division of Gastroenterology, Hepatology, & Nutrition, Emory University, Atlanta, GA, USA. Electronic address: hhuneau@emory.edu. FAU - Sudhakar, Shrramana Ganesh AU - Sudhakar SG AD - School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA; Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA; Department of Biomedical Engineering, Duke University, Durham, NC, USA. FAU - Gent, Alasdair E AU - Gent AE AD - Department of Surgery, Duke University School of Medicine, Durham, NC, USA; Department of Anesthesiology, Duke University, Durham, NC, USA. FAU - Jarrell, Zachery R AU - Jarrell ZR AD - Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University, Atlanta, GA, USA. FAU - Smith, Matthew Ryan AU - Smith MR AD - Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University, Atlanta, GA, USA; VA Healthcare System of Atlanta, Decatur, GA, USA. FAU - Sanchez-Torres, Cristian AU - Sanchez-Torres C AD - Department of Pediatrics, Division of Gastroenterology, Hepatology, & Nutrition, Emory University, Atlanta, GA, USA. FAU - Jain, Ajay K AU - Jain AK AD - Department of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO, USA. FAU - Yates, Katherine P AU - Yates KP AD - Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Neuschwander-Tetri, Brent A AU - Neuschwander-Tetri BA AD - Department of Internal Medicine, Saint Louis University, St. Louis, Missouri, USA. FAU - Schwimmer, Jeffrey B AU - Schwimmer JB AD - Department of Gastroenterology, Rady Children's Hospital San Diego, San Diego, CA, USA; Department of Pediatrics, School of Medicine, University of California, San Diego, CA, USA. FAU - Xanthakos, Stavra A AU - Xanthakos SA AD - Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. FAU - Molleston, Jean P AU - Molleston JP AD - Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Riley Children's Health, Indianapolis, IN, USA. FAU - Behling, Cynthia A AU - Behling CA AD - Sharp Memorial Hospital, San Diego, California, USA. FAU - Fishbein, Mark H AU - Fishbein MH AD - Department of Pediatrics, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, USA. FAU - Kamaleswaran, Rishikesan AU - Kamaleswaran R AD - Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA; Department of Biomedical Engineering, Duke University, Durham, NC, USA; Department of Surgery, Duke University School of Medicine, Durham, NC, USA; Department of Anesthesiology, Duke University, Durham, NC, USA; Department of Electrical and Computer Engineering, Duke University, Durham, NC, USA. FAU - Vos, Miriam B AU - Vos MB AD - Department of Pediatrics and Human Development, Michigan State University, College of Human Medicine, Grand Rapids, MI, USA; Department of Pediatrics, Division of Gastroenterology, Hepatology, & Nutrition, Emory University, Atlanta, GA, USA; Children's Healthcare of Atlanta, Atlanta, GA, USA; Helen DeVos Children's Hospital, Corewell Health, Grand Rapids, MI, USA. LA - eng PT - Journal Article DEP - 20260830 PL - Netherlands TA - JHEP Rep JT - JHEP reports : innovation in hepatology JID - 101761237 SB - IM OTO - NOTNLM OT - MASLD OT - biomarker discovery OT - gradient boosting OT - histology COIS- Conflicts of interest MBV serves as a consultant to Boehringer Ingelheim, Novo Nordisk, Eli Lilly, Intercept, Takeda, and Alberio. She has stock or stock options in Thiogenesis and Tern Pharmaceuticals. Her institution has received research grants (or in-kind research services) from Target Real World Evidence, Quest, Labcorp, and Sonic Incytes Medical Corp. JPM has research grant funding from Gilead, Abbvie, Albireo, and Mirum. BANT: Advisor or consultant: Abbvie, Akero, Aldeyra, Aligos, Arrowhead, Corcept, Galectin, GSK, Hepion, HistoIndex, Madrigal, Merck, Mirum, Pfizer, Sagimet, Senseion; Stock options: HepGene, HeptaBio; Institutional research grants: Madrigal. SAX: Institutional research grants: Target Real World Evidence. EDAT- 2026/08/30 23:36 MHDA- 2026/08/30 23:36 CRDT- 2026/08/30 19:10 PHST- 2026/03/04 00:00 [received] PHST- 2026/08/08 00:00 [revised] PHST- 2026/08/21 00:00 [accepted] PHST- 2026/08/30 23:36 [pubmed] PHST- 2026/08/30 23:36 [medline] PHST- 2026/08/30 19:10 [entrez] AID - S2589-5559(26)00287-9 [pii] AID - 10.1016/j.jhepr.2026.102016 [doi] PST - aheadofprint SO - JHEP Rep. 2026 Aug 30:102016. doi: 10.1016/j.jhepr.2026.102016. PMID- 42666156 OWN - NLM STAT- MEDLINE DCOM- 20260829 LR - 20260908 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Scale-up of the Diactive-1 mHealth program integrating tailored resistance training as an educational strategy for self-management in children and adolescents with type 1 diabetes: protocol for an 11-hospital multicenter randomized controlled trial. PG - 1913568 LID - 10.3389/fendo.2026.1913568 [doi] LID - 1913568 AB - INTRODUCTION: Physical activity is strongly recommended for youth with type 1 diabetes, yet many children and adolescents do not meet current exercise guidelines, partly because of fear of hypoglycemia. Resistance training may offer metabolic and musculoskeletal benefits, but its implementation in routine pediatric diabetes care remains limited. Diactive-1 is an mHealth program designed to deliver tailored resistance-training sessions combined with glucose-management educational support. This multicenter trial aims to evaluate the effectiveness of Diactive-1 (v2.0) in improving hangrip strength in children and adolescents with type 1 diabetes. METHODS: This study is a 12-week, parallel-group, multicenter randomized controlled trial conducted across 11 Spanish pediatric endocrinology units. The target sample size is 158 children and adolescents aged 10-18 years with type 1 diabetes, with 79 participants allocated to each group. Participants will be randomized to either the Diactive-1 intervention or usual clinical care. The intervention group will use the Diactive-1 (v2.0) app, which provides individualized resistance-training programs, glucose-related educational prompts, safety thresholds for exercise, and engagement strategies such as gamification. The primary outcome will be the change in age- and sex-standardized handgrip strength z-score from baseline to 12 weeks. Secondary outcomes will include glycemic stability, insulin requirements, cardiometabolic markers, physical literacy, quality of life, psychological well-being, app usability, and intervention engagement. Analyses will follow the intention-to-treat principle using mixed-effects models. EXPECTED OUTCOMES AND DISCUSSION: This trial will assess whether a scalable mHealth-supported resistance-training program can improve muscular strength and support diabetes self-management in routine pediatric care. By testing Diactive-1 across multiple hospitals and real-world settings, the study will provide evidence on the external validity, feasibility, and potential clinical integration of digitally supported exercise education for youth with type 1 diabetes. ETHICS AND DISSEMINATION: Ethical approval was granted by the Research Ethics Committee for Medicinal Products of the Government of Navarra. Written informed consent will be obtained from parents or legal guardians, with age-appropriate assent from minors. Findings will be disseminated through scientific conferences, peer-reviewed publications, and summaries shared with participating families. CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov/study/NCT07290868, identifier NCT07290868. CI - Copyright (c) 2026 Sanchez-Arlegui, Munoz-Pardeza, Hormazabal-Aguayo, Abio-Abero, Bertholt-Zuber, Alonso-Rubio, Burillo-Sanchez, Chueca-Guindulain, Cifuentes-Zamalloa, Congost-Marin, Diez-Lopez, Ferrer-Lozano, Garcia-Navas, Gonzalez-Garcia, Huidobro-Fernandez, Lalaguna-Mallada, Llorente-Cereza, Maeso-Mendez, Riano-Galan, Ruiz-del Campo, Salcedo Fresneda, Vara-Callau, Vela-Desojo, Ezzatvar and Garcia-Hermoso. FAU - Sanchez-Arlegui, Amaia AU - Sanchez-Arlegui A AD - Public Healthcare Service of Navarra-Osasunbidea (SNS-O), Universidad Publica de Navarra (UPNA), Pamplona, Spain. FAU - Munoz-Pardeza, Jacinto AU - Munoz-Pardeza J AD - Navarrabiomed, Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain. FAU - Hormazabal-Aguayo, Ignacio AU - Hormazabal-Aguayo I AD - Navarrabiomed, Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain. AD - Office of the Vice-Rector for Research and Graduate Studies, Universidad de La Serena, La Serena, Chile. FAU - Abio-Abero, Sonia AU - Abio-Abero S AD - Pediatrics Service, Hospital San Jorge, Huesca, Spain. FAU - Bertholt-Zuber, Maria Laura AU - Bertholt-Zuber ML AD - Pediatric Endocrinology Unit, Hospital Universitario Marques de Valdecilla, Santander, Spain. FAU - Alonso-Rubio, Pablo AU - Alonso-Rubio P AD - Pediatric Endocrinology Unit, Hospital Universitario Marques de Valdecilla, Santander, Spain. FAU - Burillo-Sanchez, Elisabet AU - Burillo-Sanchez E AD - Pediatric Endocrinology Unit, Hospital Universitario de Navarra, Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain. FAU - Chueca-Guindulain, Maria J AU - Chueca-Guindulain MJ AD - Pediatric Endocrinology Unit, Hospital Universitario de Navarra, Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain. FAU - Cifuentes-Zamalloa, Claudia AU - Cifuentes-Zamalloa C AD - Pediatric Endocrinology Unit, Hospital Universitario Cruces, Barakaldo, Spain. FAU - Congost-Marin, Sofia AU - Congost-Marin S AD - Pediatric Endocrinology Unit, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain. FAU - Diez-Lopez, Ignacio AU - Diez-Lopez I AD - Pediatrics Service, Hospital de Araba, Vitoria, Spain. FAU - Ferrer-Lozano, Marta AU - Ferrer-Lozano M AD - Pediatric Endocrinology Unit, Hospital Infantil Miguel Servet, Zaragoza, Spain. FAU - Garcia-Navas, Patricia AU - Garcia-Navas P AD - Pediatrics Service, Hospital San Pedro, Logrono, Spain. FAU - Gonzalez-Garcia, Lara Gloria AU - Gonzalez-Garcia LG AD - Pediatrics Service, Hospital de Cabuenes, Gijon, Spain. FAU - Huidobro-Fernandez, Belen AU - Huidobro-Fernandez B AD - Pediatrics Service, Hospital de Cabuenes, Gijon, Spain. FAU - Lalaguna-Mallada, Paula AU - Lalaguna-Mallada P AD - Pediatrics Service, Hospital de Barbastro, Huesca, Spain. FAU - Llorente-Cereza, Maria Teresa AU - Llorente-Cereza MT AD - Pediatric Endocrinology Unit, Hospital Universitario de Navarra, Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain. FAU - Maeso-Mendez, Sandra AU - Maeso-Mendez S AD - Pediatrics Service, Hospital de Araba, Vitoria, Spain. FAU - Riano-Galan, Isolina AU - Riano-Galan I AD - Pediatric Endocrinology Unit, Hospital Universitario Central de Asturias, Oviedo, Spain. FAU - Ruiz-Del Campo, Maria AU - Ruiz-Del Campo M AD - Pediatrics Service, Hospital San Pedro, Logrono, Spain. FAU - Salcedo Fresneda, Oihane AU - Salcedo Fresneda O AD - Pediatric Endocrinology Unit, Hospital Universitario Central de Asturias, Oviedo, Spain. FAU - Vara-Callau, Marta AU - Vara-Callau M AD - Pediatric Endocrinology Unit, Hospital Infantil Miguel Servet, Zaragoza, Spain. FAU - Vela-Desojo, Amaia AU - Vela-Desojo A AD - Pediatric Endocrinology Unit, Hospital Universitario Cruces, Barakaldo, Spain. FAU - Ezzatvar, Yasmin AU - Ezzatvar Y AD - Lifestyle factors with impact on Ageing and overall Health (LAH) Research Group, Departamento de Enfermeria, Universidad de Valencia, Valencia, Spain. AD - Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno, Chile. FAU - Garcia-Hermoso, Antonio AU - Garcia-Hermoso A AD - Navarrabiomed, Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain. LA - eng SI - ClinicalTrials.gov/NCT07290868 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260814 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/therapy MH - Child MH - Adolescent MH - *Resistance Training/methods MH - Multicenter Studies as Topic MH - Female MH - *Self-Management/education/methods MH - Male MH - Randomized Controlled Trials as Topic MH - *Patient Education as Topic/methods MH - Telemedicine MH - Quality of Life PMC - PMC13521802 OTO - NOTNLM OT - digital health OT - education OT - mHealth OT - strength training OT - type 1 diabetes COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/29 05:35 MHDA- 2026/08/29 05:36 PMCR- 2026/08/14 CRDT- 2026/08/29 04:31 PHST- 2026/06/19 00:00 [received] PHST- 2026/07/22 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/08/29 05:36 [medline] PHST- 2026/08/29 05:35 [pubmed] PHST- 2026/08/29 04:31 [entrez] PHST- 2026/08/14 00:00 [pmc-release] AID - 10.3389/fendo.2026.1913568 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Aug 14;17:1913568. doi: 10.3389/fendo.2026.1913568. eCollection 2026. PMID- 42665051 OWN - NLM STAT- MEDLINE DCOM- 20261005 LR - 20261005 IS - 1938-3207 (Electronic) IS - 0002-9165 (Linking) VI - 124 IP - 4 DP - 2026 Oct TI - Major dietary protein sources during pregnancy and obesity risk in mothers and offspring: A prospective cohort study. PG - 101508 LID - S0002-9165(26)00317-5 [pii] LID - 10.1016/j.ajcnut.2026.101508 [doi] AB - BACKGROUND: Maternal protein intake during pregnancy may influence long-term obesity risk in mothers and offspring, but the role of specific dietary protein sources remains unclear. OBJECTIVES: This study aimed to examine the associations of major dietary protein sources during pregnancy with maternal postpartum weight retention (PPWR) and offspring overweight/obesity, and to evaluate isocaloric substitution between sources. METHODS: In 59,791 mothers from the Danish National Birth Cohort (1996-2002), diet at 25 wk of gestation was assessed by a validated food-frequency questionnaire. Log-binomial regression and isocaloric substitution models estimated adjusted relative risks (RRs) for maternal PPWR >5 kg at 6-18 mo postpartum and offspring overweight/obesity at ages 7-11 y. RESULTS: Overall, 10,678 (22.1%) mothers had PPWR >5 kg, and 8287 (19.0%) offspring developed overweight/obesity. Comparing highest with lowest quintile of intake (% energy), higher total plant [RR: 0.86; 95% confidence interval (CI): 0.81, 0.91], grain (RR: 0.87; 95% CI: 0.82, 0.91), legume and nut (RR: 0.93; 95% CI: 0.88, 0.98), poultry (RR: 0.90; 95% CI: 0.85, 0.95), and fish protein (RR: 0.90; 95% CI: 0.86, 0.95) were associated with lower maternal PPWR risk, whereas higher red meat protein intake with higher risk (RR: 1.11; 95% CI: 1.05, 1.17). For offspring overweight/obesity, higher total animal (RR: 1.12; 95% CI: 1.05, 1.19), red meat (RR: 1.06; 95% CI: 1.00, 1.13), and dairy protein (RR: 1.11; 95% CI: 1.04, 1.17) were associated with higher risk, whereas poultry (RR: 0.95; 95% CI: 0.89, 0.99) and fish protein (RR: 0.93; 95% CI: 0.88, 0.99) with modestly lower risk. Replacing 1% of energy from total animal protein with plant protein, or from red meat or dairy protein with poultry, fish, or grain protein, was associated with 4%-6% lower maternal PPWR risk; corresponding substitutions with poultry or fish protein were associated with 3%-4% lower offspring risk. CONCLUSIONS: During pregnancy, substituting poultry or fish protein for red meat or dairy protein was associated with lower risks of both maternal PPWR and offspring overweight/obesity, supporting consideration of protein source in food-based dietary guidance. CI - Copyright (c) 2026 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Zhang, Hanyue AU - Zhang H AD - Research Unit for Diet and Health, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark; Global Centre for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Electronic address: hanyue.zhang@nus.edu.sg. FAU - Zheng, Miaobing AU - Zheng M AD - School of Health Sciences, Faculty of Health & Medicine, University of New South Wales, Sydney, Australia. FAU - Halldorsson, Thornorhallur I AU - Halldorsson ThornI AD - Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark; Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland. FAU - Olsen, Sjurdur F AU - Olsen SF AD - Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark; Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, United States. FAU - Simpson, Stephen J AU - Simpson SJ AD - Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia; School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia. FAU - Raubenheimer, David AU - Raubenheimer D AD - Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia; School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia. FAU - Heitmann, Berit L AU - Heitmann BL AD - Research Unit for Diet and Health, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark; Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia; Section for General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark; Faculty of Health, Deakin University, Melbourne, Victoria, Australia. Electronic address: Berit.Lilienthal.Heitmann@regionh.dk. LA - eng PT - Journal Article DEP - 20260911 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 RN - 0 (Dietary Proteins) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Dietary Proteins/administration & dosage MH - *Obesity/etiology/epidemiology MH - Prospective Studies MH - Denmark/epidemiology MH - Adult MH - Child MH - *Maternal Nutritional Physiological Phenomena MH - Diet MH - Risk Factors MH - Overweight/etiology/epidemiology MH - Postpartum Period MH - Cohort Studies OTO - NOTNLM OT - Danish National Birth Cohort OT - childhood obesity OT - dietary protein OT - postpartum weight retention OT - pregnancy OT - protein source OT - substitution analysis COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/08/28 23:34 MHDA- 2026/10/05 23:29 CRDT- 2026/08/28 19:11 PHST- 2026/05/09 00:00 [received] PHST- 2026/08/21 00:00 [revised] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/10/05 23:29 [medline] PHST- 2026/08/28 23:34 [pubmed] PHST- 2026/08/28 19:11 [entrez] AID - S0002-9165(26)00317-5 [pii] AID - 10.1016/j.ajcnut.2026.101508 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Oct;124(4):101508. doi: 10.1016/j.ajcnut.2026.101508. Epub 2026 Sep 11. PMID- 42663907 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20261008 IS - 1867-0687 (Electronic) VI - 22 IP - 7 DP - 2026 Jul TI - Waist-to-height ratio as a practical indicator for screening pediatric metabolic dysfunction-associated steatotic liver disease in diverse populations and genetic backgrounds. PG - 805-818 LID - 10.1007/s12519-026-01084-9 [doi] AB - BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading chronic liver disease in children and adolescents; this parallels the global obesity epidemic. The contribution of genetic susceptibility to pediatric MASLD, and its interaction with anthropometric and biochemical indices used for non-invasive screening remains poorly understood. We aimed to evaluate waist-to-height ratio (WHtR) as a simple, equitable, and scalable tool for early identification of pediatric MASLD and relate this to genetic risk. METHODS: We combined school-based data from 1010 Chinese children with analyses of the Global Burden of Disease, the 1000 Genomes Project, and the US National Health and Nutrition Examination Survey (NHANES). Thirteen MASLD-related single-nucleotide polymorphisms (SNPs) were genotyped to construct a genetic risk score (GRS). We examined global epidemiological patterns, quantified inter-population allele divergence, and assessed how GRS modifies cutoffs and performance of nine anthropometric and biochemical indices. RESULTS: Genetic analysis revealed minimal frequency divergence across most ancestries (mean Fixation index < 0.05), except for the African ancestry where there was moderate divergence. Higher GRS were associated with lower cutoffs across indices. When GRS Z-score increased from -3 to 3, visceral adiposity index showed the sharpest changes (Z-score decreased from 1.5 to -1.8), while BFP (1.2 to 0.1) and WHtR (1.5 to 0.1) showed gradual change. Furthermore, incorporating GRS into the base anthropometric models yielded only marginal improvements in overall screening performance [area under the receiver operating characteristic curve (AUC) and Youden Index]. Validation in NHANES showed WHtR >/= 0.48 retained high discrimination (AUC > 0.87) across most genetic variants. CONCLUSIONS: This study suggests that WHtR is a consistent and practical tool for screening pediatric patients with MASLD across diverse populations. While genetic variation may influence optimal thresholds, WHtR >/= 0.48 appears broadly applicable, supporting its potential use as a frontline screening metric in diverse settings. CI - (c) 2026. Children's Hospital, Zhejiang University School of Medicine. FAU - Liu, Yun-Fei AU - Liu YF AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Wang, You-Xin AU - Wang YX AD - Department of Maternal and Child Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Li, Li AU - Li L AD - Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, China. FAU - Shi, Di AU - Shi D AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Wolters, Maike AU - Wolters M AD - Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. FAU - Zhang, Ping-Ping AU - Zhang PP AD - Ningbo Center for Healthy Lifestyle Research, The First Affiliated Hospital of Ningbo University, Ningbo, China. FAU - Dang, Jia-Jia AU - Dang JJ AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Cai, Shan AU - Cai S AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Huang, Tian-Yu AU - Huang TY AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Wang, Ya-Qi AU - Wang YQ AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Liu, Jie-Yu AU - Liu JY AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Wang, Ming-Yue AU - Wang MY AD - Department of Maternal and Child Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Wu, Yu-Ying AU - Wu YY AD - Department of Maternal and Child Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Nur, Enkar AU - Nur E AD - Department of Maternal and Child Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Lian, Wen-Jia AU - Lian WJ AD - Department of Maternal and Child Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Guo, Li-Po AU - Guo LP AD - Changping Health Education Center for Primary and Secondary Schools, Beijing, China. FAU - Li, Yuan-Yuan AU - Li YY AD - Changping Health Education Center for Primary and Secondary Schools, Beijing, China. FAU - Song, Jie-Yun AU - Song JY AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Li, Jing AU - Li J AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Dong, Yan-Hui AU - Dong YH AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Cui, Yan-Chun AU - Cui YC AD - Beijing Children's Hospital, Capital Medical University, Beijing, China. FAU - Hebestreit, Antje AU - Hebestreit A AD - Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. FAU - Yeo, Yee Hui AU - Yeo YH AD - Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, USA. FAU - Sawyer, Susan M AU - Sawyer SM AD - Department of Paediatrics, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia. AD - Murdoch Children's Research Institute, Parkville, VIC, Australia. AD - Centre for Adolescent Health, Royal Children's Hospital, Parkville, VIC, Australia. FAU - Wang, Hui AU - Wang H AD - Department of Maternal and Child Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. huiwang@bjmu.edu.cn. FAU - Song, Yi AU - Song Y AUID- ORCID: 0000-0001-6990-6781 AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. songyi@bjmu.edu.cn. LA - eng GR - 2022-1G-4251/Capital's Funds for Health Improvement and Research/ GR - 82273654/National Natural Science Foundation of China/ GR - LTGY24H260007/Zhejiang Provincial Natural Science Foundation of China/ GR - 2025KY1315/Medical Health Science and Technology Project of Zhejiang Province/ GR - 2022-B126/Cyrus Tang Foundation for Young Scholar 2022/ GR - 202406010179/China Scholarship Council/ GR - 202406010169/China Scholarship Council/ PT - Journal Article DEP - 20260828 PL - Switzerland TA - World J Pediatr JT - World journal of pediatrics : WJP JID - 101278599 SB - IM MH - Humans MH - Child MH - Female MH - *Waist-Height Ratio MH - Male MH - Genetic Predisposition to Disease MH - Adolescent MH - *Fatty Liver/diagnosis/genetics/epidemiology MH - Polymorphism, Single Nucleotide MH - China MH - Mass Screening/methods MH - Genetic Risk Score MH - Nutrition Surveys OTO - NOTNLM OT - Genetic variants OT - Metabolic dysfunction-associated steatotic liver disease OT - Pediatric OT - Screening OT - Waist-to-height ratio COIS- Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: The Beijing study and Ningbo study received approval from the Ethics Committee of Review Board of Peking University Health Science Center (Approval No. 00001052-22018) and the Ethics Committee of Ningbo First Hospital (Approval No. 2021-R168), respectively. Written informed consent was obtained from the children and their parents prior to enrollment. Analyses based on the GBD, 1000G Project, and NHANES datasets used publicly available de-identified data and therefore did not require additional ethical approval. The authors confirm that they are accountable for all aspects of the work including full data access, data integrity, and accuracy of data analysis. EDAT- 2026/08/28 18:06 MHDA- 2026/09/15 18:07 CRDT- 2026/08/28 11:27 PHST- 2025/12/23 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/03/11 00:00 [revised] PHST- 2026/09/15 18:07 [medline] PHST- 2026/08/28 18:06 [pubmed] PHST- 2026/08/28 11:27 [entrez] AID - 10.1007/s12519-026-01084-9 [pii] AID - 10.1007/s12519-026-01084-9 [doi] PST - ppublish SO - World J Pediatr. 2026 Jul;22(7):805-818. doi: 10.1007/s12519-026-01084-9. Epub 2026 Aug 28. PMID- 42663493 OWN - NLM STAT- Publisher LR - 20260828 IS - 1941-2452 (Electronic) IS - 0884-5336 (Linking) DP - 2026 Aug 28 TI - Seeing is believing: The evolving role of muscle ultrasound in comprehensive nutritional care of pediatric oncology patients-A case series. LID - 10.1002/ncp.70177 [doi] AB - Traditional nutritional assessments in pediatric oncology, such as weight and body mass index, often fail to accurately capture changes in body composition, frequently masking significant muscle depletion, or secondary sarcopenia. This retrospective case series evaluates the novel clinical application of muscle ultrasound (mUS) by a pediatric oncology dietitian to help objectively guide and monitor nutrition interventions. We report our observations regarding three pediatric patients with cancer (one school-aged child and two adolescents/young adults). Serial mUS measurements of the quadriceps femoris and rectus femoris were obtained alongside standard anthropometric data. Nutritional interventions, including appetite stimulants and enteral nutrition, were tailored based on these combined assessments. In all three cases, mUS findings were discordant with total body weight trends. One patient exhibited weight gain on appetite stimulants, but mUS revealed concurrent muscle loss, prompting a transition to enteral nutrition. Conversely, another patient experienced persistent weight loss, but mUS confirmed muscle preservation and growth and led to reduced healthcare utilization. These observations suggest mUS is a feasible, non-invasive tool with potential to complement conventional anthropometric measures by detecting subclinical muscle changes that may otherwise be missed. Given the small, heterogeneous sample and retrospective design, these findings should be considered as hypothesis-generating rather than conclusive and warrant further validation in larger, prospective studies before mUS can be recommended as a standard component of nutritional assessment in pediatric oncology. CI - (c) 2026 American Society for Parenteral and Enteral Nutrition. FAU - Hawes, Corey AU - Hawes C AUID- ORCID: 0000-0002-3444-0923 AD - Department of Pediatrics, University of Kentucky, Lexington, Kentucky, USA. FAU - Radulescu, Vlad Calin AU - Radulescu VC AD - Department of Pediatrics, University of Kentucky, Lexington, Kentucky, USA. FAU - Munnikhuysen, Senna AU - Munnikhuysen S AD - Department of Pediatrics, University of Kentucky, Lexington, Kentucky, USA. LA - eng PT - Journal Article DEP - 20260828 PL - United States TA - Nutr Clin Pract JT - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JID - 8606733 SB - IM OTO - NOTNLM OT - body composition OT - muscle ultrasound OT - pediatric oncology OT - secondary sarcopenia EDAT- 2026/08/28 11:49 MHDA- 2026/08/28 11:49 CRDT- 2026/08/28 09:23 PHST- 2026/08/03 00:00 [revised] PHST- 2026/02/12 00:00 [received] PHST- 2026/08/07 00:00 [accepted] PHST- 2026/08/28 11:49 [medline] PHST- 2026/08/28 11:49 [pubmed] PHST- 2026/08/28 09:23 [entrez] AID - 10.1002/ncp.70177 [doi] PST - aheadofprint SO - Nutr Clin Pract. 2026 Aug 28. doi: 10.1002/ncp.70177. PMID- 42661870 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20260903 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Measurement tools for sedentary behavior in the Arabic-speaking countries in MENA region: a systematic review of validated instruments from the BRIDGE project. PG - 1815050 LID - 10.3389/fpubh.2026.1815050 [doi] LID - 1815050 AB - BACKGROUND: Sedentary behavior is an independent risk factor for adverse health outcomes. Screen time represents a specific domain of sedentary behavior and is often used as a proxy. Accurate measurement of these behaviors is essential for surveillance, research, and intervention. However, the availability, characteristics, and psychometric quality of validated instruments used to assess these behaviors in Arabic-speaking countries in the Middle East and North Africa (MENA) region have not been well documented. This systematic review aimed to identify, describe, and critically appraise the instruments used to assess sedentary behavior and/or screen time in this region. METHODS: This systematic review was conducted according to the PRISMA guidelines. Major electronic databases were searched to identify studies that reported the development, cross-cultural adaptation, or validation of instruments measuring sedentary behavior or screen time in Arabic-speaking MENA countries. Studies assessing at least one measurement property were eligible. Data on study characteristics, instruments, and psychometric properties were extracted. The methodological quality and measurement properties were evaluated using the COSMIN framework. RESULTS: Ten studies conducted in five MENA countries (Jordan, United Arab Emirates, Saudi Arabia, Morocco, and Syria) were included. Most studies relied on self-reported questionnaires originally designed to assess physical activity, with sedentary behavior measured as a secondary dimension. The most frequently evaluated instruments were the International Physical Activity Questionnaire (IPAQ), Global Physical Activity Questionnaire (GPAQ), and Global School-based Student Health Survey (GSHS). Only one instrument, the Sedentary Behavior Questionnaire (SBQ), was specifically designed to measure sedentary behavior and was validated in two countries among adults and university students. Overall, the psychometric properties were often insufficient or inconsistent, particularly for criterion validity. Evidence among children and adolescents is limited and mainly focuses on screen time, showing weak agreement with objective measures. CONCLUSION: The measurement of sedentary behavior in Arabic-speaking MENA countries relies largely on non-specific instruments with limited psychometric evidence. There is a clear need for the development and rigorous validation of culturally adapted, sedentary behavior-specific tools across age groups to support research, surveillance, and public health policies in the region. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261283730, Identifier: CRD420261283730. CI - Copyright (c) 2026 Bartal, Bahra, Hussien, Aly, Abdelkarim and El Rhazi. FAU - Bartal, Fatima Zahrae AU - Bartal FZ AD - Laboratory of Epidemiology, Clinical Research, and Community Health, Faculty of Medicine, Pharmacy, and Dentistry, Sidi Mohamed Ben Abdallah University, Fez, Morocco. FAU - Bahra, Nassiba AU - Bahra N AD - Laboratory of Epidemiology, Clinical Research, and Community Health, Faculty of Medicine, Pharmacy, and Dentistry, Sidi Mohamed Ben Abdallah University, Fez, Morocco. FAU - Hussien, Fatma AU - Hussien F AD - Faculty of Sport Sciences, Capital University, Giza, Egypt. FAU - Aly, Mohamed AU - Aly M AD - Faculty of Sport Sciences, Assiut University, Assiut, Egypt. AD - Department of Sports Management, School of Business, ESLSCA University, Cairo, Egypt. FAU - Abdelkarim, Osama AU - Abdelkarim O AD - Faculty of Sport Sciences, Assiut University, Assiut, Egypt. AD - Department of Sports Management, School of Business, ESLSCA University, Cairo, Egypt. AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - El Rhazi, Karima AU - El Rhazi K AD - Laboratory of Epidemiology, Clinical Research, and Community Health, Faculty of Medicine, Pharmacy, and Dentistry, Sidi Mohamed Ben Abdallah University, Fez, Morocco. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260813 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Africa, Northern MH - Middle East MH - Middle Eastern People MH - Psychometrics MH - Reproducibility of Results MH - *Screen Time MH - *Sedentary Behavior MH - Surveys and Questionnaires/standards MH - North African People PMC - PMC13518537 OTO - NOTNLM OT - Arabic-speaking countries OT - COSMIN OT - MENA region OT - measurement instruments OT - psychometric properties OT - sedentary behavior COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/28 11:49 MHDA- 2026/08/28 11:50 PMCR- 2026/08/13 CRDT- 2026/08/28 05:23 PHST- 2026/02/21 00:00 [received] PHST- 2026/06/25 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/08/28 11:50 [medline] PHST- 2026/08/28 11:49 [pubmed] PHST- 2026/08/28 05:23 [entrez] PHST- 2026/08/13 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1815050 [doi] PST - epublish SO - Front Public Health. 2026 Aug 13;14:1815050. doi: 10.3389/fpubh.2026.1815050. eCollection 2026. PMID- 42661386 OWN - NLM STAT- Publisher LR - 20260828 IS - 1467-789X (Electronic) IS - 1467-7881 (Linking) DP - 2026 Aug 27 TI - Harnessing Systems Science to Strengthen Community-Based Childhood Obesity Prevention: An Overview of the Literature. PG - e70218 LID - 10.1111/obr.70218 [doi] AB - INTRODUCTION: Addressing the obesity epidemic requires understanding the complex and multilevel dynamics that shape it. Systems science can help researchers and practitioners move beyond linear causal logic. This overview identifies empirical studies using explicit systems science methods or broader systems-informed approaches to design, implement, or evaluate community-based childhood obesity prevention efforts. We report how systems methods have been applied, their contributions to tackling obesity, challenges, and opportunities. METHODS: We searched Web of Science for English-language publications reporting empirical applications of systems thinking, systems science methods, or systems-informed ecological and participatory approaches in community-level childhood obesity prevention. Three reviewers screened 273 records, assessed full texts, and extracted data. RESULTS: Ninety-eight articles met inclusion criteria. Systems approaches were used most often during intervention design (n = 50; 51.0%), followed by implementation (n = 23; 23.5%) and evaluation (n = 14; 14.3%), with some spanning multiple stages (n = 11; 11.2%). Participatory methods such as group model building deepened understanding of structural and relational drivers, and supported context-specific adaptation and cross-sector coordination. The use of systems approaches for evaluation was limited, though emerging methods (e.g., ripple-effect mapping, longitudinal network analysis, and agent-based modeling) signal growing opportunity. Barriers included limited infrastructure for cross-sector collaboration, funding misalignment, and a lack of shared or validated metrics. CONCLUSION: Systems science has strengthened the field's ability to visualize complexity and align stakeholders in interventions' design and implementation. Its application in evaluation and scale-up remains limited. Sustained investment in participatory capacity, longitudinal infrastructure, and systems-informed implementation is needed to strengthen community-based childhood obesity prevention. CI - (c) 2026 The Author(s). Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation. FAU - Moore, Travis R AU - Moore TR AUID- ORCID: 0000-0002-7874-0813 AD - Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA. AD - Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Chang Chusan, Yuilyn A AU - Chang Chusan YA AD - Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA. FAU - Calancie, Larissa AU - Calancie L AUID- ORCID: 0000-0002-8943-5590 AD - Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA. FAU - Tamvakologos, Panos I AU - Tamvakologos PI AUID- ORCID: 0009-0000-3450-7713 AD - School of Medicine, St. Georges University, University Centre, St. George's, Grenada. AD - Department of Pediatrics, Maimonides Children's Hospital, Brooklyn, New York, USA. FAU - Economos, Christina D AU - Economos CD AD - Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA. LA - eng PT - Journal Article PT - Review DEP - 20260827 PL - England TA - Obes Rev JT - Obesity reviews : an official journal of the International Association for the Study of Obesity JID - 100897395 SB - IM OTO - NOTNLM OT - childhood OT - community OT - obesity OT - primary care OT - systems science EDAT- 2026/08/28 11:46 MHDA- 2026/08/28 11:46 CRDT- 2026/08/28 01:43 PHST- 2026/07/20 00:00 [revised] PHST- 2026/02/10 00:00 [received] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/08/28 11:46 [medline] PHST- 2026/08/28 11:46 [pubmed] PHST- 2026/08/28 01:43 [entrez] AID - 10.1111/obr.70218 [doi] PST - aheadofprint SO - Obes Rev. 2026 Aug 27:e70218. doi: 10.1111/obr.70218. PMID- 42660934 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260830 IS - 2396-8370 (Electronic) IS - 2396-8370 (Linking) VI - 10 IP - 1 DP - 2026 Aug 7 TI - A machine learning-derived dietary pattern for aging. LID - 10.1038/s41538-026-01048-3 [doi] LID - 264 AB - Diet is a modifiable determinant of aging. We develop and validate the Machine-learning YouTHful (MYTH) Diet, a dietary pattern associated with reduced aging-related mortality. Using data from 191,689 participants in the UK Biobank, we conducted a food-wide association analysis and identified 18 food groups significantly associated with aging-related mortality. A Light Gradient Boosting Machine (LightGBM) model was used to rank food importance, leading to the construction of a 10-component MYTH Diet score (range: 0-10). Higher MYTH scores were consistently associated with reduced aging-related mortality in both internal (Quartile 4 vs. 1: hazard ratio [HR] = 0.79; 95% CI: 0.75-0.84) and external (Q4 vs. Q1: HR = 0.68; 95% CI: 0.58-0.80) validation cohorts. Multi-omics analyses revealed that the diet's protective effects were partly mediated through proteomic, metabolic, and inflammatory pathways, with mediators including TNFRSF4, the proportion of polyunsaturated fatty acids (PUFA%), and lipid-related metabolites such as medium very-low-density lipoprotein phospholipids (M-VLDL-PL). Higher MYTH scores were also linked to slower biological aging in the lungs, liver, pancreas, as well as lower risks for 15 aging-related diseases. These findings suggest that the MYTH Diet may offer a biologically informed, scalable framework for developing personalized nutrition strategies aimed at supporting healthy aging and longevity. CI - (c) 2026. The Author(s). FAU - Miao, Yating AU - Miao Y AD - Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention, Ministry of Education, China Medical University; Department of Biostatistics and Epidemiology, School of Public Health, China Medical University, Shenyang, China. FAU - Li, Zhirong AU - Li Z AD - Department of Social Medicine and Health Management, School of Public Health, Jilin University, Changchun, China. FAU - Zhang, Xinyao AU - Zhang X AD - Department of Social Medicine and Health Management, School of Public Health, Jilin University, Changchun, China. food@jlu.edu.cn. FAU - Liu, Zuyun AU - Liu Z AD - Department of Big Data in Health Science School of Public Health, Center for Clinical Big Data and Analytics Second Affiliated Hospital, Zhejiang Key Laboratory of Intelligent Preventive Medicine, Zhejiang University School of Medicine, Hangzhou, China. Zuyun.liu@outlook.com. FAU - Ma, Yanan AU - Ma Y AD - Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention, Ministry of Education, China Medical University; Department of Biostatistics and Epidemiology, School of Public Health, China Medical University, Shenyang, China. ynma@cmu.edu.cn. AD - Health Sciences Institute, China Medical University; Liaoning Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang, China. ynma@cmu.edu.cn. LA - eng GR - 72074221/National Natural Science Foundational of China/ GR - 2026-MS-190/Natural Science Foundation of Liaoning Province/ PT - Journal Article DEP - 20260807 PL - England TA - NPJ Sci Food JT - NPJ science of food JID - 101739627 PMC - PMC13522610 COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/08/28 11:46 MHDA- 2026/08/28 11:47 PMCR- 2026/08/07 CRDT- 2026/08/27 23:21 PHST- 2026/04/13 00:00 [received] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/08/28 11:47 [medline] PHST- 2026/08/28 11:46 [pubmed] PHST- 2026/08/27 23:21 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - 10.1038/s41538-026-01048-3 [pii] AID - 1048 [pii] AID - 10.1038/s41538-026-01048-3 [doi] PST - epublish SO - NPJ Sci Food. 2026 Aug 7;10(1):264. doi: 10.1038/s41538-026-01048-3. PMID- 42656734 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260828 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 7 DP - 2026 Jul TI - Internet Gaming Addiction in Children and Adolescents: A Narrative Review in the Context of Screen Time. PG - e113441 LID - 10.7759/cureus.113441 [doi] LID - e113441 AB - Internet gaming addiction in children and adolescents is an emerging clinical and public health concern within the broader context of increasing recreational screen exposure. Despite growing recognition of gaming disorder, uncertainty remains regarding its distinction from high recreational gaming, its relationship with screen time, and the most appropriate prevention and management strategies for pediatric populations. This narrative review aimed to synthesise evidence published between 2013 and 2026 on diagnostic concepts, epidemiological patterns, screen-time context, mental and physical health associations, and intervention approaches for problematic gaming in children and adolescents. Relevant literature was reviewed and organised into diagnostic, clinical, public health, and therapeutic domains. The conclusions were derived from qualitative narrative synthesis rather than pooled quantitative analysis. Current evidence indicates that gaming disorder should not be defined by screen-time duration alone, but by impaired control, persistence despite harm, prioritisation of gaming over essential activities, and functional impairment across academic, social, developmental, and family domains. Prevalence estimates vary because of differences in diagnostic criteria, assessment tools, cultural gaming practices, and study populations. Excessive gaming commonly overlaps with emotional symptoms, sleep disturbance, sedentary behaviour, reduced physical activity, academic difficulties, social withdrawal, and family conflict. Available evidence suggests potential benefit from multidimensional management involving validated assessment, cognitive behavioural strategies, relapse prevention, parental involvement, school-based digital literacy, structured offline activities, and coordinated pediatric mental health care. Screen-time reduction is important, but restriction alone is insufficient. Given the absence of formal evidence grading and risk-of-bias assessment, conclusions regarding intervention effectiveness should be interpreted cautiously. Pediatric gaming disorder requires impairment-based assessment and developmentally appropriate, family-supported intervention rather than simple screen-time control. CI - Copyright (c) 2026, Sharma et al. FAU - Sharma, Neena AU - Sharma N AD - Department of Physiology, All India Institute of Medical Sciences (AIIMS), Jammu, Jammu, IND. LA - eng PT - Journal Article PT - Review DEP - 20260727 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13508007 OTO - NOTNLM OT - adolescents OT - gaming disorder OT - internet gaming addiction OT - pediatric mental health OT - screen time COIS- Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/08/27 12:36 MHDA- 2026/08/27 12:37 PMCR- 2026/07/27 CRDT- 2026/08/27 06:08 PHST- 2026/07/24 00:00 [accepted] PHST- 2026/08/27 12:37 [medline] PHST- 2026/08/27 12:36 [pubmed] PHST- 2026/08/27 06:08 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - 10.7759/cureus.113441 [doi] PST - epublish SO - Cureus. 2026 Jul 27;18(7):e113441. doi: 10.7759/cureus.113441. eCollection 2026 Jul. PMID- 42656511 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260828 IS - 2347-5625 (Print) IS - 2349-6673 (Electronic) IS - 2347-5625 (Linking) VI - 13 DP - 2026 Dec TI - Development and preliminary validation of the Exercise Fit Tool for adolescents undergoing cancer treatment in Hong Kong. PG - 101005 LID - 10.1016/j.apjon.2026.101005 [doi] LID - 101005 AB - OBJECTIVE: This study aimed to develop and preliminarily validate the Exercise Fit Tool (EFT), a patient-reported self-assessment tool for adolescents undergoing cancer treatment in Hong Kong. METHODS: A convenience sample of 158 adolescents aged 13-18 years who were undergoing cancer treatment and could communicate in Cantonese and read Chinese was recruited in Hong Kong. Instrument development followed the procedures recommended in AMEE Guide No. 87. Candidate items were generated from a literature review and focus groups with adolescents and healthcare professionals, refined by an expert panel, assessed for content validity, and revised through cognitive interviews. Pilot testing was conducted in 158 adolescents. Convergent validity was examined using pain scores and forced expiratory volume in 1 second (FEV1, % predicted), and criterion-related validity was evaluated by comparing EFT scores with physiotherapists' ratings. Test-retest reliability was assessed in 50 participants, and principal component analysis with Varimax rotation was performed. RESULTS: The final 10-item EFT demonstrated satisfactory content validity, with I-CVIs ranging from 0.86 to 1.00, and good internal consistency (Cronbach's alpha = 0.92). The 2-week test-retest ICC was 0.82 (P < 0.001). EFT scores were negatively correlated with pain scores and positively correlated with FEV1 (% predicted), supporting convergent validity. The Kaiser-Meyer-Olkin measure was 0.87, and Bartlett's test of sphericity was significant (P < 0.001). Principal component analysis identified a two-component solution: cancer- and treatment-related influences on physical activity (7 items; Cronbach's alpha = 0.96; 55.7% of the rotated variance) and perceived physical activity exertion (3 items; Cronbach's alpha = 0.74; 20.6% of the rotated variance). Primary component loadings ranged from 0.74 to 0.93, and communalities ranged from 0.55 to 0.91. The two components explained 76.3% of the total variance. CONCLUSIONS: The EFT demonstrated preliminary evidence of validity and reliability for adolescents undergoing cancer treatment in Hong Kong. Further evaluation of its latent structure and implementation in independent samples is required before wider clinical use. CI - (c) 2026 The Author(s). FAU - Lam, Katherine Ka Wai AU - Lam KKW AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. FAU - Wu, Stanley AU - Wu S AD - Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China. FAU - Liu, Qi AU - Liu Q AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. FAU - Mao, Ting AU - Mao T AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. FAU - Pan, Jingda AU - Pan J AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. FAU - Jiang, Lulu AU - Jiang L AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. FAU - Li, Yanjia AU - Li Y AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. FAU - Gao, Yuwen AU - Gao Y AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. FAU - Cheng, Frankie Wai Tsoi AU - Cheng FWT AD - Hong Kong Children's Hospital, Hong Kong SAR, China. FAU - Chan, Godfrey Chi Fung AU - Chan GCF AD - Department of Paediatrics and Adolescent Medicine, School of Clinical Medicine, LKS Faculty of Medicine The University of Hong Kong, Hong Kong SAR, China. FAU - Ho, Ka Yan AU - Ho KY AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. LA - eng PT - Journal Article DEP - 20260711 PL - United States TA - Asia Pac J Oncol Nurs JT - Asia-Pacific journal of oncology nursing JID - 101673157 PMC - PMC13506534 OTO - NOTNLM OT - Adolescents OT - Cancer OT - Patient-reported outcome OT - Physical activity OT - Reliability OT - Validation COIS- The authors declare no conflict of interest. EDAT- 2026/08/27 12:36 MHDA- 2026/08/27 12:37 PMCR- 2026/07/11 CRDT- 2026/08/27 05:40 PHST- 2025/11/11 00:00 [received] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/08/27 12:37 [medline] PHST- 2026/08/27 12:36 [pubmed] PHST- 2026/08/27 05:40 [entrez] PHST- 2026/07/11 00:00 [pmc-release] AID - S2347-5625(26)00155-1 [pii] AID - 101005 [pii] AID - 10.1016/j.apjon.2026.101005 [doi] PST - epublish SO - Asia Pac J Oncol Nurs. 2026 Jul 11;13:101005. doi: 10.1016/j.apjon.2026.101005. eCollection 2026 Dec. PMID- 42654495 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260829 IS - 1648-9144 (Electronic) IS - 1010-660X (Print) IS - 1010-660X (Linking) VI - 62 IP - 8 DP - 2026 Aug 20 TI - Maternal Vulnerability Indicators Derived from Free-Text Clinical Documentation in Adolescent Pregnancy. LID - 10.3390/medicina62081598 [doi] LID - 1598 AB - Background and Objectives: Adolescent pregnancy is associated with biological, behavioral, and healthcare-related vulnerabilities that are incompletely captured by structured datasets. This study aimed to characterize selected maternal vulnerability indicators derived from narrative clinical documentation and to examine their exploratory associations with documented prenatal care deficiency and neonatal outcomes. Materials and Methods: We conducted a retrospective cohort study including 759 singleton adolescent pregnancies managed at a Romanian secondary obstetric center between 2020 and 2024. Narrative clinical observations were reviewed to extract maternal vulnerability indicators, including smoking, anemia, infection, hypertensive disorders, obesity, Rh incompatibility, and documented prenatal care deficiency. Associations between extracted variables, documented prenatal care deficiency, and neonatal outcomes were evaluated using contingency analyses, Kendall's tau-b correlations, and multivariable logistic regression models. Results: Among pregnancies with available narrative observations, documented prenatal care deficiency was identified in 612/692 (88.4%), maternal anemia in 207/692 (29.9%), and smoking during pregnancy in 186/692 (26.9%). Validation performance differed across categories, with a sensitivity of 57.1% (95% CI 18.4-90.1%) for hypertensive disorders and wide confidence intervals for rare categories. Correlations between extracted variables were weak, indicating limited clustering of maternal risk factors. Hypertensive disorders (aOR 0.31, 95% CI 0.10-0.95, p = 0.038) and maternal obesity (aOR 0.39, 95% CI 0.16-0.98, p = 0.044) were associated with lower odds of documented prenatal care deficiency. Significant neonatal associations were observed primarily for low birth weight. Hypertensive disorders were independently associated with increased odds of low birth weight (aOR 3.56, 95% CI 1.33-9.54, p = 0.011), whereas documented maternal anemia was associated with lower observed odds of LBW (aOR 0.45, 95% CI 0.24-0.82, p = 0.009). No significant associations were identified for preterm birth or Apgar score < 7 at 5 min. Conclusions: Narrative clinical documentation allowed the identification of heterogeneous maternal vulnerability indicators that showed weak interrelationships and selective associations with prenatal surveillance patterns and low birth weight. These exploratory findings should be interpreted in the context of healthcare engagement and documentation practices. FAU - Sandor, Florin Mihai AU - Sandor FM AUID- ORCID: 0009-0008-4137-7388 AD - Multidisciplinary Doctoral School, "Vasile Goldis" Western University of Arad, 310414 Arad, Romania. AD - Department of Life Sciences, "Vasile Goldis" Western University of Arad, 310414 Arad, Romania. FAU - Precup, Cris Virgiliu AU - Precup CV AUID- ORCID: 0009-0009-4299-5652 AD - Department of Life Sciences, "Vasile Goldis" Western University of Arad, 310414 Arad, Romania. FAU - Furau, Cristian George AU - Furau CG AUID- ORCID: 0000-0001-7158-2579 AD - Multidisciplinary Doctoral School, "Vasile Goldis" Western University of Arad, 310414 Arad, Romania. AD - Department of Life Sciences, "Vasile Goldis" Western University of Arad, 310414 Arad, Romania. FAU - Edu, Antoine AU - Edu A AD - Department 13-Obstetrics and Gynecology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania. AD - Nicolae Malaxa Clinical Hospital, 022441 Bucharest, Romania. FAU - Edu, Mihnea-Dan AU - Edu MD AD - Department 13-Obstetrics and Gynecology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania. AD - Nicolae Malaxa Clinical Hospital, 022441 Bucharest, Romania. FAU - Coroleuca, Ciprian AU - Coroleuca C AUID- ORCID: 0000-0002-2043-9307 AD - Department 13-Obstetrics and Gynecology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania. AD - Panait Sarbu Clinical Hospital of Obstetrics and Gynecology, 060251 Bucharest, Romania. FAU - Furau, Roxana AU - Furau R AD - Department of General Medicine, Faculty of Medicine, "Vasile Goldis" Western University of Arad, 310414 Arad, Romania. FAU - Rosca, Ioana AU - Rosca I AUID- ORCID: 0009-0002-4629-5820 AD - Panait Sarbu Clinical Hospital of Obstetrics and Gynecology, 060251 Bucharest, Romania. AD - Faculty of Midwifery and Nursery, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania. FAU - Mateescu, Radu Nicolae AU - Mateescu RN AD - Department 13-Obstetrics and Gynecology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania. AD - Nicolae Malaxa Clinical Hospital, 022441 Bucharest, Romania. LA - eng PT - Journal Article DEP - 20260820 PL - Switzerland TA - Medicina (Kaunas) JT - Medicina (Kaunas, Lithuania) JID - 9425208 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Adolescent MH - Retrospective Studies MH - *Pregnancy in Adolescence/statistics & numerical data MH - Romania/epidemiology MH - *Prenatal Care/statistics & numerical data/standards MH - Cohort Studies MH - *Documentation/methods/statistics & numerical data/standards MH - Pregnancy Complications/epidemiology MH - Risk Factors MH - Logistic Models MH - Pregnancy Outcome/epidemiology MH - Infant, Newborn PMC - PMC13515706 OTO - NOTNLM OT - adolescent pregnancy OT - low birth weight OT - maternal vulnerability OT - narrative clinical documentation OT - perinatal epidemiology OT - prenatal care deficiency OT - routinely collected health data COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/20 CRDT- 2026/08/27 01:10 PHST- 2026/07/16 00:00 [received] PHST- 2026/08/05 00:00 [revised] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:10 [entrez] PHST- 2026/08/20 00:00 [pmc-release] AID - medicina62081598 [pii] AID - medicina-62-01598 [pii] AID - 10.3390/medicina62081598 [doi] PST - epublish SO - Medicina (Kaunas). 2026 Aug 20;62(8):1598. doi: 10.3390/medicina62081598. PMID- 42654307 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260829 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 16 DP - 2026 Aug 20 TI - Social Media and out of Home Food Selection and Health Promoting Choices: A Generational Perspective in Poland. LID - 10.3390/nu18162727 [doi] LID - 2727 AB - OBJECTIVE: This study investigates the relationship between social media use and consumer purchase intentions or out-of-home food choices in the Polish gastronomic market, focusing specifically on variations across generations. METHODOLOGY: Data were collected between May and July 2024 through a diagnostic survey using the Computer-Assisted Web Interviewing (CAWI) technique (N = 1099). Respondents were recruited via a non-probability quota sampling approach based on strict demographic inclusion criteria. To test the research hypotheses regarding generational variations in market behaviour, a multivariate discriminant function analysis was performed using Statistica 13.1 PL. A preliminary pilot study (N = 30) confirmed the initial questionnaire readability and overall consistency (Cronbach's alpha = 0.87), while subscales were treated independently during the main analysis. RESULTS: Multivariate models were found to be highly significant, revealing clear differences between age groups. The youngest cohort (aged 18-35) relies heavily on Instagram and TikTok, showing distinct patterns regarding visual triggers such as "instagrammable" aesthetics, digital validation, and menu uniqueness alongside weight loss claims. Conversely, seniors (aged 61 and older) lean unexpectedly towards X. This older segment displays pragmatic, utility-driven motives, searching for detailed textual data about ingredients and the health-promoting properties of food. General product quality and calorie control were identified as universal factors that do not vary by generation. Conclusions and Managerial Implications: The digital transformation of the Polish restaurant industry does not follow a single path. Social media is closely linked to modern customer journeys, with physical dining spots frequently serving as spaces for socialisation. Consequently, restaurant operators should move away from mass communication and adopt a selective omnichannel strategy, where message formats shift from visual appeal to factual, nutrition-oriented text that is tailored to the digital literacy and dietary needs of each generation. FAU - Soroka, Andrzej AU - Soroka A AD - Faculty of Medical and Health Sciences, University of Siedlce, Boleslawa. Prusa 14, 08-110 Siedlce, Poland. FAU - Godlewska, Agnieszka AU - Godlewska A AD - Faculty of Medical and Health Sciences, University of Siedlce, Boleslawa. Prusa 14, 08-110 Siedlce, Poland. FAU - Mazurek-Kusiak, Anna Katarzyna AU - Mazurek-Kusiak AK AUID- ORCID: 0000-0002-3786-8861 AD - Department of Tourism and Recreation, University of Life Sciences in Lublin, Akademicka 15, 20-950 Lublin, Poland. LA - eng GR - 233/26/B/Ministry of Science and Higher Education/ PT - Journal Article DEP - 20260820 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Poland MH - *Food Preferences/psychology MH - *Social Media/statistics & numerical data MH - Female MH - Middle Aged MH - Adult MH - *Consumer Behavior/statistics & numerical data MH - *Choice Behavior MH - Male MH - Adolescent MH - *Health Promotion MH - Young Adult MH - Surveys and Questionnaires MH - Aged MH - Digital Media PMC - PMC13516072 OTO - NOTNLM OT - consumer behaviour OT - discriminant function analysis OT - food choices OT - gastronomic market OT - intergenerational differences OT - social media COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/20 CRDT- 2026/08/27 01:10 PHST- 2026/07/15 00:00 [received] PHST- 2026/08/16 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:10 [entrez] PHST- 2026/08/20 00:00 [pmc-release] AID - nu18162727 [pii] AID - nutrients-18-02727 [pii] AID - 10.3390/nu18162727 [doi] PST - epublish SO - Nutrients. 2026 Aug 20;18(16):2727. doi: 10.3390/nu18162727. PMID- 42654292 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260829 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 16 DP - 2026 Aug 19 TI - Reproducibility of a 69-Item School Children's Food Frequency Questionnaire (69-Item SCh-FFQ) and Diet Quality Scores Among Polish Children Aged 7-9 Years. LID - 10.3390/nu18162712 [doi] LID - 2712 AB - Background/Objectives: Reliable dietary assessment tools are essential for evaluating dietary habits and diet quality in children. The aim of this study was to assess the reproducibility of a 69-item School Children's Food Frequency Questionnaire (69-item SCh-FFQ) and the diet quality scores among Polish children aged 7-9 years. Methods: The reproducibility study was conducted among 77 children. The 69-item SCh-FFQ was administered twice (test and retest). Data on food consumption frequency were used to evaluate two diet quality scores: the pro-Healthy Diet Index (pHDI) and the non-Healthy Diet Index (nHDI). The reproducibility of the 69-item SCh-FFQ and the diet quality scores was evaluated using comparisons of mean values, cross-classification analysis, Cohen's kappa statistic, Spearman's rank correlation coefficient, intraclass correlation coefficient (ICC), and Bland-Altman analysis. Results: No significant differences were observed between test and retest of the FFQ for mean values of the pHDI (2.9 +/- 1.8 vs. 2.8 +/- 1.9 points; p = 0.124) or the nHDI (4.3 +/- 1.5 vs. 4.2 +/- 1.5 points; p = 0.611). Total agreement for the classification of children into categories of the diet quality scores reached 81.8% for pHDI and 75.3% for nHDI, with low gross misclassification rates (1.3% and 0.0%, respectively). Cohen's kappa statistic indicated moderate to good agreement (kappa = 0.68 for pHDI and kappa = 0.51 for nHDI). For all food items, total agreement ranged from 66.2% to 94.8%, while the kappa statistic ranged from 0.56 to 0.81. Strong correlations and good agreement were observed between repeated measurements for both pHDI (r = 0.748, ICC = 0.778; p < 0.001) and nHDI (r = 0.783, ICC = 0.752; p < 0.001). Bland-Altman analysis demonstrated good agreement and no evidence of proportional bias. Conclusions: The 69-item SCh-FFQ demonstrated satisfactory reproducibility for assessing food consumption frequency and diet quality scores in children aged 7-9 years. Therefore, this questionnaire is a promising tool for future epidemiological studies among early school-aged children, although its utility should be confirmed in further validation studies using an appropriate reference method. FAU - Sobas, Kamila AU - Sobas K AUID- ORCID: 0000-0003-4246-6944 AD - Institute of Health Sciences, Medical College, Jan Kochanowski University, 5 Zeromskiego Street, 25-369 Kielce, Poland. FAU - Kowalkowska, Joanna AU - Kowalkowska J AUID- ORCID: 0000-0003-1981-7320 AD - Department of Human Nutrition, Faculty of Food Science, University of Warmia and Mazury in Olsztyn, 45F Sloneczna Street, 10-718 Olsztyn, Poland. FAU - Suliga, Edyta AU - Suliga E AUID- ORCID: 0000-0003-3063-0380 AD - Institute of Health Sciences, Medical College, Jan Kochanowski University, 5 Zeromskiego Street, 25-369 Kielce, Poland. AD - Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 36A Postepu Street, 05-552 Magdalenka, Poland. FAU - Wadolowska, Lidia AU - Wadolowska L AUID- ORCID: 0000-0001-8571-9935 AD - Department of Human Nutrition, Faculty of Food Science, University of Warmia and Mazury in Olsztyn, 45F Sloneczna Street, 10-718 Olsztyn, Poland. LA - eng PT - Journal Article DEP - 20260819 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - Reproducibility of Results MH - Poland MH - Female MH - Male MH - *Feeding Behavior MH - *Diet Surveys MH - *Nutrition Assessment MH - Surveys and Questionnaires MH - *Diet MH - *Diet, Healthy PMC - PMC13516586 OTO - NOTNLM OT - diet quality OT - dietary assessment OT - food consumption frequency OT - reliability OT - school-aged children COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/19 CRDT- 2026/08/27 01:10 PHST- 2026/07/02 00:00 [received] PHST- 2026/08/17 00:00 [revised] PHST- 2026/08/18 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:10 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - nu18162712 [pii] AID - nutrients-18-02712 [pii] AID - 10.3390/nu18162712 [doi] PST - epublish SO - Nutrients. 2026 Aug 19;18(16):2712. doi: 10.3390/nu18162712. PMID- 42654273 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260829 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 16 DP - 2026 Aug 18 TI - Maternal Dietary B-Complex Vitamin Pattern and Risk of Complex Congenital Heart Defects in a Mexican Population. LID - 10.3390/nu18162693 [doi] LID - 2693 AB - BACKGROUND/OBJECTIVES: Congenital heart defects (CHDs) are among the most common congenital anomalies worldwide, and maternal nutrition during early pregnancy may influence their development. Although previous studies have mainly evaluated individual B-complex vitamins, the contribution of their combined dietary intake to CHD risk remains poorly understood. This study investigated the association between maternal dietary B-complex vitamin intake and the risk of complex CHDs in a Mexican case-control study. METHODS: Maternal dietary intake during pregnancy was assessed using a validated food frequency questionnaire, and nutrient intakes were energy-adjusted. Principal component analysis was used to construct a B-Complex Index based on the combined intake of vitamins B1, B2, B3, B6, and B12. Associations were evaluated using multivariable logistic regression adjusted for maternal age, total energy intake, multivitamin supplementation during pregnancy, and periconceptional folic acid supplementation. RESULTS: Mothers of children with complex CHDs had significantly lower dietary intakes of B-complex vitamins than control mothers. The B-Complex Index was independently associated with lower odds of complex CHDs (adjusted OR = 0.707, 95% CI: 0.586-0.843; p = 0.0001). CONCLUSIONS: These findings suggest that evaluating the overall maternal dietary pattern of selected B-complex vitamins may provide complementary information regarding the nutritional environment relevant to early cardiac development. Prospective studies integrating dietary assessment, biomarkers, and genetic susceptibility are warranted to confirm these findings and further elucidate the underlying biological mechanisms. FAU - Vilchis-Gil, Jenny AU - Vilchis-Gil J AUID- ORCID: 0000-0002-5473-6772 AD - Unidad de Investigacion Epidemiologica en Endocrinologia y Nutricion, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. AD - Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico City 04510, Mexico. FAU - Gomez-Jimenez, Aaron M AU - Gomez-Jimenez AM AUID- ORCID: 0009-0003-1099-0431 AD - Departamento de Matematicas, Facultad de Ciencias, Universidad Nacional Autonoma de Mexico, Mexico City 04510, Mexico. FAU - Santillan-Orgas, Maria E AU - Santillan-Orgas ME AD - Departamento de Neonatologia, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. FAU - Segura-Stanford, Begona AU - Segura-Stanford B AD - Departamento de Cardiologia, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. FAU - Navarro-Castellanos, Inaki AU - Navarro-Castellanos I AUID- ORCID: 0000-0002-7680-0835 AD - Departamento de Cardiologia, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. FAU - Gomez-Lopez, Jacqueline AU - Gomez-Lopez J AD - Hospital Militar de Especialidades de la Mujer y Neonatologia, Secretaria de la Defensa Nacional, Mexico City 11200, Mexico. FAU - Moran-Espinosa, Mari C AU - Moran-Espinosa MC AD - Laboratorio de Investigacion en Patogenesis Molecular, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. FAU - Granados-Riveron, Javier T AU - Granados-Riveron JT AD - Laboratorio de Investigacion en Patogenesis Molecular, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. FAU - Sanchez-Urbina, Rocio AU - Sanchez-Urbina R AUID- ORCID: 0000-0001-8018-7749 AD - Laboratorio de Investigacion en Cardiogenetica, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. AD - Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico City 11340, Mexico. LA - eng GR - HIM/2019/049/Hospital Infantil de Mexico Federico Gomez/ PT - Journal Article DEP - 20260818 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 12001-76-2 (Vitamin B Complex) SB - IM MH - Humans MH - Female MH - *Heart Defects, Congenital/epidemiology/etiology/prevention & control MH - Mexico/epidemiology MH - Pregnancy MH - *Maternal Nutritional Physiological Phenomena MH - Case-Control Studies MH - Adult MH - *Vitamin B Complex/administration & dosage MH - Risk Factors MH - *Diet MH - Dietary Supplements MH - Young Adult PMC - PMC13516518 OTO - NOTNLM OT - B-complex vitamins OT - congenital heart defects OT - maternal nutrition OT - one-carbon metabolism OT - pregnancy OT - principal component analysis COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/18 CRDT- 2026/08/27 01:10 PHST- 2026/06/29 00:00 [received] PHST- 2026/08/03 00:00 [revised] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:10 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - nu18162693 [pii] AID - nutrients-18-02693 [pii] AID - 10.3390/nu18162693 [doi] PST - epublish SO - Nutrients. 2026 Aug 18;18(16):2693. doi: 10.3390/nu18162693. PMID- 42654217 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260829 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 16 DP - 2026 Aug 12 TI - Development and Validation of the Food Consumption Rate Questionnaire (FCRQ): A Behaviorally Informed Measure of Eating-Rate Regulation. LID - 10.3390/nu18162637 [doi] LID - 2637 AB - Background: Eating-rate regulation is a multidimensional behavioral process shaped by oral-processing dynamics, interoceptive cues, sensory engagement, and contextual influences. Despite its relevance, no validated self-report instrument currently assesses these mechanisms. Methods: The Food Consumption Rate Questionnaire (FCRQ) was developed as a behaviorally informed tool for measuring eating-rate regulation. Item generation followed a theory-driven process supported by expert review, forward-backward translation, and pilot testing. Structural validity was examined through Exploratory Factor Analysis (Principal Axis Factoring, Promax rotation) and a theory-driven Confirmatory Factor Analysis evaluating the proposed four-domain model. Reliability was assessed using Cronbach's alpha and corrected item-total correlations. Behavioral heterogeneity was explored using hierarchical and k-means cluster analysis. Results: A clear four-factor structure emerged-Slowness, Awareness of Eating Rate, External Factors, and Awareness & Enjoyment-explaining 42.77% of the variance. CFA indicated acceptable model fit (CFI = 0.93, TLI = 0.91, RMSEA = 0.052), supporting the adequacy of the theoretical structure. Reliability indices were consistent with the multidimensional nature of the construct. All four domains were positively correlated. Cluster analysis identified distinct behavioral profiles, illustrating the instrument's discriminative capacity. Conclusions: The FCRQ provides the first behaviorally informed, psychometrically evaluated framework for assessing eating-rate regulation. The instrument demonstrates a coherent theoretical structure, satisfactory early-stage validity, and the ability to differentiate meaningful behavioral patterns. Continued refinement and validation across diverse populations will further establish the FCRQ as a robust measure for behavioral-nutrition research and practice. FAU - Koliou, Maria P AU - Koliou MP AUID- ORCID: 0009-0009-1751-5629 AD - Laboratory of Food Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece. FAU - Karaiskou, Chrysoula AU - Karaiskou C AD - Sidroco Holdings Ltd., Nicosia 1082, Cyprus. FAU - Eleftheriadis, Charalampos AU - Eleftheriadis C AUID- ORCID: 0000-0002-0726-4127 AD - Sidroco Holdings Ltd., Nicosia 1082, Cyprus. FAU - Skalkos, Dimitris AU - Skalkos D AUID- ORCID: 0000-0002-7771-2845 AD - Laboratory of Food Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece. LA - eng PT - Journal Article PT - Validation Study DEP - 20260812 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Reproducibility of Results MH - *Feeding Behavior/psychology MH - Surveys and Questionnaires/standards MH - Psychometrics MH - Female MH - Factor Analysis, Statistical MH - Male MH - Adult MH - *Eating/psychology MH - Young Adult MH - Adolescent PMC - PMC13516422 OTO - NOTNLM OT - Food Consumption Rate Questionnaire (FCRQ) OT - behavioral nutrition OT - confirmatory factor analysis OT - eating-rate regulation OT - factor analysis OT - interoceptive awareness OT - psychometric evaluation OT - questionnaire development OT - questionnaire validation OT - sensory engagement COIS- C.K. and C.E. were employed by Sidroco Holdings Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/12 CRDT- 2026/08/27 01:09 PHST- 2026/07/25 00:00 [received] PHST- 2026/08/09 00:00 [revised] PHST- 2026/08/11 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:09 [entrez] PHST- 2026/08/12 00:00 [pmc-release] AID - nu18162637 [pii] AID - nutrients-18-02637 [pii] AID - 10.3390/nu18162637 [doi] PST - epublish SO - Nutrients. 2026 Aug 12;18(16):2637. doi: 10.3390/nu18162637. PMID- 42652618 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 16 DP - 2026 Aug 11 TI - Artificial Intelligence for Personalized Prediction of Post-TIPS Outcomes: Integrating Clinical, Biochemical, and Radiomics Data-A Narrative Review. LID - 10.3390/jcm15166211 [doi] LID - 6211 AB - Transjugular intrahepatic portosystemic shunt (TIPS) is an established treatment for complications of portal hypertension, but hepatic encephalopathy (HE), liver dysfunction, rebleeding, and mortality remain difficult to predict in otherwise eligible candidates. However, predicting post-TIPS outcomes remains challenging using conventional risk scores such as MELD 3.0 and Child-Turcotte-Pugh. This narrative review critically evaluates how clinical, biochemical, procedural, conventional imaging, handcrafted radiomics, and deep-learning features can be integrated for personalized post-TIPS risk prediction, supplemented by backward and forward reference checking. Thirty-two original post-TIPS studies met the core inclusion criteria: 18 focused primarily on clinical, biochemical, hemodynamic, microbiome, or procedural predictors and 14 on imaging, body composition, radiomics, or multimodal models. AI, ML, and radiomics models, by the aim of logistic regression, tree-based ensembles, support vector machines, artificial neural networks, and hybrid deep-learning models, able to capture non-linear interactions, have consistently demonstrated improved predictive performance compared with conventional scores, particularly for HE, with reported incidences of approximately 20-47%, mortality, and liver dysfunction. Their advantage lies in the ability to model complex, non-linear relationships and integrate heterogeneous data sources, including laboratory parameters, ammonia levels, hemodynamic variables, and imaging-derived features. Radiomics and deep learning approaches further enhance predictive accuracy. CT is currently the principal imaging substrate, while direct post-TIPS radiomics evidence for MRI and ultrasound remains sparse. Studies of liver and spleen morphology, portal-vein geometry, muscle and adipose tissue, and radiomic texture suggest incremental information beyond conventional scores, particularly when clinical and imaging features are combined; however, negative volumetric findings show that additional image features do not automatically improve prediction. However, most studies are retrospective, single-center, and lack external validation and no validated transformer-based or other sequence model has yet been established for post-TIPS outcomes. Standardization issues in radiomics and limited model interpretability remain significant barriers. Future directions should lead to prospective multicenter cohort validation, increasing sample sizes, harmonized imaging and endpoint definitions, locked external validation with recalibration, and the development of clinically interpretable tools to make it easier to identify those patients suitable for TIPS and their post-procedural management. FAU - Barrancotto, Alessio AU - Barrancotto A AD - Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy. FAU - Di Cola, Simone AU - Di Cola S AUID- ORCID: 0000-0002-6414-4404 AD - Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy. FAU - Melandro, Fabio AU - Melandro F AUID- ORCID: 0000-0003-4056-9245 AD - Department of General Surgery and Surgical Specialties Paride Stefanini, Sapienza University of Rome, 00185 Rome, Italy. FAU - Lapenna, Lucia AU - Lapenna L AUID- ORCID: 0000-0002-6761-4969 AD - Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy. FAU - Vignone, Anthony AU - Vignone A AUID- ORCID: 0000-0001-6009-2398 AD - Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy. FAU - Bencivenga, Antonio AU - Bencivenga A AD - Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy. FAU - Brancati, Arianna AU - Brancati A AD - Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy. FAU - Lucatelli, Pierleone AU - Lucatelli P AUID- ORCID: 0000-0002-7448-1404 AD - Department of Radiological Sciences, Oncology and Pathology, Sapienza University of Rome, 00185 Rome, Italy. FAU - Corona, Mario AU - Corona M AD - Department of Radiological Sciences, Oncology and Pathology, Sapienza University of Rome, 00185 Rome, Italy. FAU - Gioia, Stefania AU - Gioia S AUID- ORCID: 0000-0002-3940-4390 AD - Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy. FAU - Nardelli, Silvia AU - Nardelli S AUID- ORCID: 0000-0002-7038-9539 AD - Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy. LA - eng PT - Journal Article PT - Review DEP - 20260811 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13513915 OTO - NOTNLM OT - TIPS OT - artificial intelligence OT - body composition OT - explainable AI OT - hepatic encephalopathy OT - machine learning OT - multimodal prediction OT - radiomics OT - risk prediction COIS- The authors declare no conflict of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/11 CRDT- 2026/08/27 01:06 PHST- 2026/07/03 00:00 [received] PHST- 2026/08/05 00:00 [revised] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:06 [entrez] PHST- 2026/08/11 00:00 [pmc-release] AID - jcm15166211 [pii] AID - jcm-15-06211 [pii] AID - 10.3390/jcm15166211 [doi] PST - epublish SO - J Clin Med. 2026 Aug 11;15(16):6211. doi: 10.3390/jcm15166211. PMID- 42652543 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 16 DP - 2026 Aug 7 TI - Psychiatric and Psychosocial Outcomes of Bariatric Surgery in Adolescents and Adult Women: A Prospective Cohort Study. LID - 10.3390/jcm15166139 [doi] LID - 6139 AB - Background/Objectives: The rising prevalence of severe adolescent obesity has increased the number of young patients referred for bariatric surgery. The psychiatric and psychosocial profiles of adolescents and of adult women undergoing this treatment remain insufficiently characterized. This study compared preoperative and postoperative psychiatric, psychosocial, and metabolic profiles of adolescents and adult women undergoing bariatric surgery. Methods: This prospective cohort study recruited 77 consecutive female patients (32 adolescents aged <18 years; 45 adult women aged 18-25 years) at a single bariatric center in Poland between December 2022 and December 2023. All participants underwent comprehensive preoperative and one-year postoperative assessments including laboratory testing, standardized psychiatric interviews, and psychometric screening with the Beck Depression Inventory (BDI) and the Patient Health Questionnaire-9 (PHQ-9). Results: Preoperatively, adolescents were more severely affected for their age (median BMI-for-age z-score 3.53) and waited longer between the first obesity clinic visit and surgery. Adolescents more frequently reported self-harm behaviors and moderate-to-severe depression on the BDI, whereas adult women more often reported psychoactive substance use. Both groups achieved comparable improvements in laboratory and comorbidity outcomes at one year, although relative weight loss was greater in adult women (median total weight loss 37.6% vs. 28.4%, p < 0.0001). Postoperatively, a greater proportion of adolescents than adult women improved with respect to social anxiety (50.0% vs. 13.3%, p = 0.0007) and BDI depression severity (53.1% vs. 24.4%, p = 0.02), whereas a greater proportion of adult women improved with respect to psychoactive substance use (46.7% vs. 12.5%, p = 0.003). Generalized anxiety and suicidal ideation declined within both groups, but the extent of improvement did not differ significantly between them. These differences persisted, and for several outcomes became larger, after adjustment for the reduction in BMI, which was smaller in adolescents. Conclusions: In this observational cohort, bariatric surgery was associated with distinct psychiatric and psychosocial outcome profiles in adolescents compared with adult women. Because the study was uncontrolled and included no non-surgical comparison group, these findings are hypothesis-generating and cannot establish a causal effect of surgery or of its timing; confirmation in larger, multicenter studies with appropriate comparison groups is required. Comprehensive multidisciplinary perioperative care and tailored postoperative psychological support appear important for both age groups. FAU - Herstowska, Marta AU - Herstowska M AUID- ORCID: 0000-0002-0905-6233 AD - Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, 80-210 Gdansk, Poland. FAU - Przygocka-Pieniazek, Ada AU - Przygocka-Pieniazek A AUID- ORCID: 0000-0001-7831-0242 AD - Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, 80-210 Gdansk, Poland. FAU - Lejk, Agnieszka AU - Lejk A AD - Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, 80-210 Gdansk, Poland. FAU - Burzynski, Jacek AU - Burzynski J AD - Department of Biostatistics and Translational Medicine, Medical University of Lodz, 92-215 Lodz, Poland. FAU - Mysliwiec, Malgorzata AU - Mysliwiec M AD - Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, 80-210 Gdansk, Poland. FAU - Kaska, Lukasz AU - Kaska L AD - Hospital of the Ministry of the Interior and Administration, 80-104 Gdansk, Poland. LA - eng PT - Journal Article DEP - 20260807 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13513403 OTO - NOTNLM OT - adolescent obesity OT - bariatric surgery OT - depression OT - mental health OT - psychosocial outcomes COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/07 CRDT- 2026/08/27 01:06 PHST- 2026/06/25 00:00 [received] PHST- 2026/08/02 00:00 [revised] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:06 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - jcm15166139 [pii] AID - jcm-15-06139 [pii] AID - 10.3390/jcm15166139 [doi] PST - epublish SO - J Clin Med. 2026 Aug 7;15(16):6139. doi: 10.3390/jcm15166139. PMID- 42651535 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 8 DP - 2026 Aug 7 TI - The Association Between Physical Activity and Physical Literacy Among Adolescents: A Cross-Sectional Study. LID - 10.3390/bs16081358 [doi] LID - 1358 AB - This study examined the association between physical activity (PA) patterns and physical literacy (PL) among adolescents in Shanghai, China. The researchers conducted a cross-sectional survey between December 2021 and February 2022. They recruited 1624 adolescents aged 11 to 18 from schools in various districts of Shanghai using stratified sampling. Out of these, 1500 provided complete and valid questionnaires for analysis. The researchers assessed PL using a validated adolescent Physical Literacy Questionnaire and measured PA with an updated PA questionnaire that included school-based, household, transportation, and leisure activities. The demographic factors considered included gender, school stage, academic performance, and family socioeconomic status (SES). Two-way multivariate analysis of variance (MANOVA) and multiple linear regression analyses were used to explore group differences and the connections between PA and PL. The MANOVA results showed significant differences in PA based on gender (F(1,1498) = 7.94, p < 0.001) and school stage (F(1,1498) = 9.79, p < 0.001). However, no significant differences were found concerning academic performance (F(1,1498) = 2.12, p = 0.081) or SES (F(1,1498) = 1.90, p = 0.072). On the other hand, PL varied significantly by school stage (F(1,1498) = 9.55, p < 0.001), academic performance (F(1,1498) = 8.84, p < 0.05), and SES (F(1,1498) = 7.94, p < 0.05), but not by gender (F(1,1498) = 1.90, p = 0.121). Furthermore, multiple regression analyses revealed that involvement in school-based, transportation, and leisure-time PA was positively associated with adolescents' PL, whereas household PA was not. These findings suggest that adolescents' participation in PA and their PL vary among different demographic groups. Additionally, different PA contexts are associated with varying degrees of PL development. Because of the cross-sectional nature of the study, these findings should be seen as associative rather than indicating a causal relationship. Programs that encourage participation in school-based, transportation, and leisure activities may help improve adolescents' physical literacy. FAU - Qian, Song AU - Qian S AD - School of Marxism, Shanghai University of Sport, No. 399, Changhai Road, Yangpu District, Shanghai 200438, China. FAU - Wang, Xuebin AU - Wang X AD - Department of Physical Education, Shanghai Jiao Tong University, Shanghai 200240, China. AD - Post-Doctoral Station of Sport Science, Fujian Normal University, Cangshan Campus, No. 8 Shangsan Road, Cangshan District, Fuzhou 350007, China. FAU - Dan, He AU - Dan H AD - School of Journalism and Communication, Shanghai University of Sport, No. 399, Changhai Road, Yangpu District, Shanghai 200438, China. FAU - Qin, Yuke AU - Qin Y AD - School of Education, City University of Macau, Avenida Padre Tomas Pereira, Taipa, Macau 999078, China. LA - eng GR - 22CTY011/National Social Science Fund Youth Projects/ GR - 2020ETY004/Shanghai Social Science Planning Youth Project/ GR - C2-2020012/Shanghai Education Science Research Projects/ PT - Journal Article DEP - 20260807 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13509980 OTO - NOTNLM OT - adolescents OT - household PA OT - moderate-to-vigorous PA OT - physical activity OT - physical literacy OT - school-based PA COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/07 CRDT- 2026/08/27 01:04 PHST- 2026/04/20 00:00 [received] PHST- 2026/07/07 00:00 [revised] PHST- 2026/07/25 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:04 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - bs16081358 [pii] AID - behavsci-16-01358 [pii] AID - 10.3390/bs16081358 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Aug 7;16(8):1358. doi: 10.3390/bs16081358. PMID- 42651518 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 8 DP - 2026 Aug 4 TI - Beyond Screen Time: Parent-Adolescent Relationship as a Mediating Pathway Between Problematic Internet Use and Psychological Well-Being Among Malaysian Adolescents. LID - 10.3390/bs16081341 [doi] LID - 1341 AB - The construct of adolescent psychological well-being has long been a focus of both public discourse and scholarly inquiry. With the widespread adoption of the Internet, there have been growing concerns about adolescents' exposure to escalating online risks. Parental mediation has been hypothesised to facilitate the guidance and regulation of adolescents' Internet use. However, the specific mediating role of the parent-adolescent relationship in the association between problematic Internet use and psychological well-being has remained underexamined, a gap explored in the current study. Based on the theoretical underpinnings provided by Phase Three of Bronfenbrenner's Bioecological Model of Human Development, a cross-sectional survey using validated psychometric instruments was conducted, involving 1598 students (mean age 16.0 years; 51% female) from secondary schools in Selangor, Malaysia. For data analysis, inferential statistics and partial least squares-structural equation modelling (PLS-SEM) were used to examine the complex structural relationships among the variables. Mean scores for problematic Internet use and psychological well-being indicated moderate severity levels. SEM results indicated the negative influence of problematic Internet use on psychological well-being (beta = -0.104 *, p = 0.040) and parent-adolescent relationship (beta = -0.241 **, p < 0.001) and a significant positive influence of parent-adolescent relationship on psychological well-being (beta = 0.328 **, p < 0.001). Subsequent mediation analysis confirmed the partial mediating effect of parent-adolescent relationship (indirect association: beta = -0.079) on the relationship between problematic Internet use and psychological well-being among Malaysian adolescents. This was consistent with Bronfenbrenner's Bioecological Model of Human Development. Strengthening the parent-adolescent relationship could mitigate the adverse psychological effects of excessive Internet use. From a policy perspective, these findings supported the use of family-focused intervention as a strategy to address the adverse psychological effects of problematic Internet use among adolescents. FAU - Okafor-Emeagha, Ijeoma Miriam AU - Okafor-Emeagha IM AUID- ORCID: 0000-0003-2561-6680 AD - Faculty of Nursing Science, Universiti Malaya, Kuala Lumpur 50603, Malaysia. FAU - Ramoo, Vimala AU - Ramoo V AUID- ORCID: 0000-0001-8506-7826 AD - School of Nursing, Faculty of Health Sciences, Nursing and Education, Mahsa University, Bandar Saujana Putra, Jenjarom 42610, Selangor, Malaysia. FAU - Marret, Mary Joseph AU - Marret MJ AUID- ORCID: 0000-0002-1739-8751 AD - Department of Pediatrics, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia. FAU - Ling, Lee Wan AU - Ling LW AUID- ORCID: 0000-0002-5584-2905 AD - Faculty of Nursing Science, Universiti Malaya, Kuala Lumpur 50603, Malaysia. LA - eng PT - Journal Article DEP - 20260804 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13510131 OTO - NOTNLM OT - adolescence OT - parental mediation OT - problematic internet use OT - psychological well-being COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/04 CRDT- 2026/08/27 01:04 PHST- 2026/05/04 00:00 [received] PHST- 2026/07/19 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:04 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - bs16081341 [pii] AID - behavsci-16-01341 [pii] AID - 10.3390/bs16081341 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Aug 4;16(8):1341. doi: 10.3390/bs16081341. PMID- 42650934 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2075-4418 (Print) IS - 2075-4418 (Electronic) IS - 2075-4418 (Linking) VI - 16 IP - 16 DP - 2026 Aug 11 TI - Applying Artificial Intelligence to Childhood Obesity: T2DM and MASLD Risk Predictive Models. LID - 10.3390/diagnostics16162533 [doi] LID - 2533 AB - Pediatric obesity is a complex, multifactorial pandemic with serious early-onset comorbidities, including prediabetes, type 2 diabetes, metabolic dysfunction-associated steatotic liver disease (MASLD), and cardiovascular disorders. While lifestyle modifications and the Mediterranean diet remain primary interventions, artificial intelligence (AI) is emerging as a critical tool for early diagnosis and personalized management. This review evaluates the current role of AI in predicting and treating childhood obesity and its complications. A literature search was conducted on PubMed and Google Scholar for English-language articles published from 2015 onward. Search terms included combinations of keywords related to "obesity", "pediatric", "comorbidities" (e.g., MASLD, diabetes), and "artificial intelligence" (e.g., machine learning, deep learning, multi-omics). Eligible study types ranged from original articles to systematic reviews and clinical guidelines. By integrating multi-omic data (genome, epigenome, transcriptome, metabolome, microbiota) with socio-psychological metrics, AI can predict obesity risk and early complications. Machine learning (ML) and deep learning have successfully identified specific metabolites, gut flora alterations, neurological pathways, and metabolic SNPs linked to obesity susceptibility. Furthermore, ML-driven prognostic models enable risk assessment for MASLD or diabetes progression, while specialized software supports remote lifestyle monitoring and tailored dietary interventions. AI has the potential to revolutionize pediatric obesity management through precision medicine. However, challenges regarding data privacy, digital literacy, and equitable access persist. Because current evidence relies heavily on limited and heterogeneous pediatric datasets, large-scale, well-characterized, and externally validated cohorts are essential to establish the clinical applicability of AI models before routine implementation. FAU - Amitrano, Marianna AU - Amitrano M AD - Unit of Pediatrics and Neonatology, Hospital "San Giovanni di Dio", 80027 Frattamaggiore, Italy. FAU - Mondillo, Gianluca AU - Mondillo G AUID- ORCID: 0009-0000-7756-8145 AD - Department of Woman, Child and of General and Specialized Surgery, Universita Degli Studi Della Campania "Luigi Vanvitelli", 80138 Naples, Italy. FAU - Emiliano, Mario AU - Emiliano M AD - Unit of Pediatrics and Neonatology, Hospital "San Giovanni di Dio", 80027 Frattamaggiore, Italy. FAU - Santoro, Umberto Paolo AU - Santoro UP AD - Department of Public Health, University of Naples "Federico II", 80131 Naples, Italy. LA - eng PT - Journal Article PT - Review DEP - 20260811 PL - Switzerland TA - Diagnostics (Basel) JT - Diagnostics (Basel, Switzerland) JID - 101658402 PMC - PMC13511550 OTO - NOTNLM OT - MASLD OT - artificial intelligence OT - childhood obesity OT - type 2 diabetes COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/11 CRDT- 2026/08/27 01:03 PHST- 2026/05/19 00:00 [received] PHST- 2026/07/25 00:00 [revised] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:03 [entrez] PHST- 2026/08/11 00:00 [pmc-release] AID - diagnostics16162533 [pii] AID - diagnostics-16-02533 [pii] AID - 10.3390/diagnostics16162533 [doi] PST - epublish SO - Diagnostics (Basel). 2026 Aug 11;16(16):2533. doi: 10.3390/diagnostics16162533. PMID- 42650380 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 8 DP - 2026 Aug 5 TI - Machine Learning-Based Prediction of Six-Minute Walk Distance in Children with Obesity. LID - 10.3390/children13081043 [doi] LID - 1043 AB - Background: The six-minute walk test (6MWT) assesses functional exercise capacity, but existing reference equations for children with obesity rely on traditional linear regression, potentially overlooking complex, non-linear relationships between anthropometric characteristics and functional exercise capacity. Objective: This study aimed to develop and internally validate machine-learning (ML) prediction models and preliminary prediction equations derived from explainable ML models for six-minute walk distance (6MWD) in Tunisian school-aged children with obesity and to compare their predictive performance with a conventional regression-based approach. Methods: We analyzed data from 236 school-aged children with obesity (104 females, 132 males; 6-12 years). Anthropometric measurements included body mass (BM), height, body mass index (BMI), waist circumference (WC), and hip circumference (HC). Five models were evaluated: linear regression, Ridge, Lasso, Elastic Net, and XGBoost. Performance was assessed using five-fold cross-validation and evaluated by the mean absolute error (MAE) and root mean square error (RMSE). Predictor importance was assessed using SHapley Additive exPlanation (SHAP) and Gini importance. Results: XGBoost achieved the best predictive performance, with the lowest MAE (17.4 +/- 2.5 m in females and 19.5 +/- 1.9 m in males) and RMSE (25.3 +/- 3.1 m in females and 26.4 +/- 2.2 m in males). Age was the strongest predictor across all models (SHAP: 54.2-62.0%; Gini importance: 0.52-0.69), followed by height and BMI. Sex-specific analyses indicated that, in females, age and BMI contributed ~80% to the cumulative SHAP analysis; whereas, in males, age, height, and WC were the primary factors. Conclusions: ML, particularly XGBoost, significantly improves 6MWD prediction in school-aged children with obesity compared with traditional linear regression. Explainable ML increases model interpretability by evaluating the relative importance of anthropometric predictors. These obesity-specific prediction models may better capture complex non-linear associations between anthropometrics and functional exercise capacity. These initial population-specific models should be validated in larger independent samples before routine use clinical or field settings. FAU - Makni, Emna AU - Makni E AUID- ORCID: 0009-0001-2941-1095 AD - Research Laboratory of Exercise Physiology and Pathophysiology (LR19ES09), Faculty of Medicine Ibn Al-Jazzar, University of Sousse, Sousse 4002, Tunisia. FAU - Elloumi, Mohamed AU - Elloumi M AUID- ORCID: 0000-0003-3751-2125 AD - Sport Sciences and Diagnostics Research Group, College of Sciences and Humanities, Prince Sultan University, Riyadh 11586, Saudi Arabia. FAU - Ammar, Achraf AU - Ammar A AUID- ORCID: 0000-0003-0347-8053 AD - Department of Training and Movement Science, Institute of Sport Science, Johannes Gutenberg-University Mainz, 55122 Mainz, Germany. AD - Research Laboratory, Molecular Bases of Human Pathology (LR19ES13), Faculty of Medicine of Sfax, University of Sfax, Sfax 3000, Tunisia. AD - Department of Nutrition and Food Technology, School of Agriculture, The University of Jordan, Amman 11942, Jordan. FAU - Brahim, Mehdi Ben AU - Brahim MB AUID- ORCID: 0000-0001-8439-0429 AD - Sport Sciences and Diagnostics Research Group, College of Sciences and Humanities, Prince Sultan University, Riyadh 11586, Saudi Arabia. FAU - Hachana, Younes AU - Hachana Y AD - Research Laboratory (LR23JS01) "Sport Performance, Health & Society", Higher Institute of Sport and Physical Education of Ksar Said, University of "La Manouba", Manouba 2037, Tunisia. LA - eng PT - Journal Article DEP - 20260805 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13511065 OTO - NOTNLM OT - anthropometry OT - explainable artificial intelligence OT - functional exercise capacity OT - pediatric obesity OT - predictive modelling COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/05 CRDT- 2026/08/27 01:02 PHST- 2026/07/03 00:00 [received] PHST- 2026/07/24 00:00 [revised] PHST- 2026/07/30 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:02 [entrez] PHST- 2026/08/05 00:00 [pmc-release] AID - children13081043 [pii] AID - children-13-01043 [pii] AID - 10.3390/children13081043 [doi] PST - epublish SO - Children (Basel). 2026 Aug 5;13(8):1043. doi: 10.3390/children13081043. PMID- 42648697 OWN - NLM STAT- Publisher LR - 20261027 IS - 1534-4436 (Electronic) IS - 1081-1206 (Linking) DP - 2026 Aug 26 TI - Pediatric Asthma Impairment and Risk Questionnaire identifies children most at risk for exacerbation. LID - S1081-1206(26)00413-8 [pii] LID - 10.1016/j.anai.2026.08.017 [doi] AB - BACKGROUND: Uncontrolled asthma symptoms and prior-year exacerbations increase the risk of future exacerbations in school-aged children. The Pediatric Asthma Impairment and Risk Questionnaire (Peds-AIRQ) is an 8-item, equally weighted, yes/no asthma control tool validated for children aged 5 to 11 years that assesses current symptoms and exacerbation history. OBJECTIVE: To determine the relationship between asthma control, as assessed by the Peds-AIRQ, and subsequent 3-month exacerbation occurrence. METHODS: At enrollment, children with asthma (aged 5 to 11 years) and their parents/caregivers completed a baseline Peds-AIRQ. Parent/caregiver-reported exacerbations were captured monthly for 3 months after enrollment via an electronic survey. Logistic regression models used the baseline Peds-AIRQ score, asthma control category (well-controlled [WC], not WC [NWC], or very poorly controlled [VPC]), age, sex, race, ethnicity, and body mass index as covariates and 1 or more subsequent 3-month exacerbations as the dependent variable. RESULTS: Of the 399 children enrolled in the Peds-AIRQ validation study, 313 completed 1 or more follow-up surveys over 3 months: mean (SD) age was 7.9 (1.9) years, 63.3% were boys, 71.6% were White, and 25.9% were Hispanic or Latino. At baseline, Peds-AIRQ categorized 39.3% of children as having WC asthma, 43.1% as having NWC asthma, and 17.6% as having VPC asthma. During the 3-month follow-up, 69 (22%) children experienced 114 exacerbations. Each 1-point increase in baseline Peds-AIRQ score was associated with 32% increased odds of 1 or more subsequent 3-month exacerbations (odds ratio [OR], 1.32; 95% CI, 1.16-1.51; P < .001). Children with VPC asthma had greater odds of exacerbation than those with WC asthma (OR, 3.85; 95% CI, 1.79-8.24; P < .001) or NWC asthma (OR, 2.56; 95% CI, 1.26-5.21; P < .01). CONCLUSION: At the point of care, Peds-AIRQ can help identify children at risk for exacerbation over 3 months. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Bacharier, Leonard B AU - Bacharier LB AD - Division of Allergy, Immunology, and Pulmonary Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee. Electronic address: leonard.bacharier@vumc.org. FAU - Chipps, Bradley E AU - Chipps BE AD - Capital Allergy & Respiratory Disease Center, Sacramento, California. FAU - Coyne, Karin S AU - Coyne KS AD - PPD Evidera Patient-Centered Research, Thermo Fisher Scientific, Waltham, Massachusetts. FAU - Eudicone, James M AU - Eudicone JM AD - AstraZeneca, Wilmington, Delaware. FAU - George, Maureen AU - George M AD - Department of Nursing, Columbia University School of Nursing, New York, New York. FAU - Gilbert, Ileen AU - Gilbert I AD - AstraZeneca, Wilmington, Delaware. FAU - Guilbert, Theresa W AU - Guilbert TW AD - Department of Pediatrics, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. FAU - Harding, Gale AU - Harding G AD - PPD Evidera Patient-Centered Research, Thermo Fisher Scientific, Waltham, Massachusetts. FAU - Lanz, Miguel J AU - Lanz MJ AD - Pediatric Allergy and Immunology, Nicklaus Children's Hospital, Miami, Florida. FAU - LeNoir, Monique AU - LeNoir M AD - African American Wellness Project, Washington, District of Columbia. FAU - Mohammad, Acklema AU - Mohammad A AD - Urban Health Plan, The Bronx, New York. FAU - Murphy, Kevin R AU - Murphy KR AD - Division of Allergy, Asthma, and Immunology, Department of Pediatric Pulmonology, Boys Town National Research Hospital, Boys Town, Nebraska. FAU - Winders, Tonya AU - Winders T AD - Global Allergy & Airways Patient Platform, Vienna, Austria. FAU - Zeiger, Robert S AU - Zeiger RS AD - Department of Clinical Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, California. LA - eng PT - Journal Article DEP - 20260826 PL - United States TA - Ann Allergy Asthma Immunol JT - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JID - 9503580 SB - IM COIS- Disclosures Dr Bacharier has served as a consultant for AstraZeneca, Avillion Life Sciences, GlaxoSmithKline (GSK), Recludix Pharma, Regeneron Pharmaceuticals, and Sanofi; has received speaker fees from Regeneron Pharmaceuticals and Sanofi; is a member of the data and safety monitoring board for Aravax, AstraZeneca, Cystic Fibrosis Foundation Therapeutics/Vertex Pharmaceuticals, and DBV Technologies; and has received research support from the National Institutes of Health and Sanofi. Dr Chipps has served as an advisor, consultant, and speaker for AstraZeneca, Boehringer Ingelheim, Circassia, Genentech, Novartis, Regeneron Pharmaceuticals, and Sanofi. Dr Coyne and Ms Harding are employees of PPD Evidera Patient-Centered Research, Thermo Fisher Scientific, which was contracted by AstraZeneca for study design and to collect and analyze data for this study. Mr Eudicone and Dr Gilbert are employees of AstraZeneca and may hold stock or stock options. Dr George has served as a consultant for AstraZeneca, Genentech/Roche, Verona Pharma, and VisionHealth; and has served as a speaker for AstraZeneca and Regeneron Pharmaceuticals. Dr Guilbert has received grants and personal fees from AstraZeneca, OM Pharma, and Sanofi/Regeneron/Amgen; has received grants from GSK; has received personal fees from Advent.com, AiCME, Genentech, PlatformQ Health, and Teva Pharmaceuticals; and has received royalties from UpToDate. Dr Lanz has served as a consultant or speaker for Amgen, Apogee, AstraZeneca, Chiesi, Genentech, Novartis, and Sanofi/Regeneron Pharmaceuticals; and has received grant funding from AstraZeneca, Genentech/Roche, and Regeneron Pharmaceuticals/Sanofi. Ms LeNoir has served on an advisory board for AstraZeneca and is a board member for the African American Wellness Project and the Digital Health for Equitable Health Alliance. Dr Mohammad has served on an advisory board for AstraZeneca. Dr Murphy has served as a consultant and speaker for AstraZeneca, Boehringer Ingelheim, Genentech, Merck, Mylan, Novartis, Optinose, Regeneron Pharmaceuticals, Sanofi, Stallergenes Greer, and Teva Pharmaceuticals. Ms Winders has served as a consultant and speaker for ALK-Abello A/S, AstraZeneca, Chiesi, Eli Lilly, Genentech, GSK, Novartis, Regeneron Pharmaceuticals, Roche, Sanofi, and Teva Pharmaceuticals. Dr Zeiger has received grant support from ALK-Abello A/S, AstraZeneca, Blueprint Medicines, Merck & Co, the National Heart, Lung, and Blood Institute, and Sanofi/Regeneron Pharmaceuticals; has received consulting fees from AstraZeneca; and has received royalties from UpToDate during the conduct of the present study. EDAT- 2026/08/26 23:35 MHDA- 2026/08/26 23:35 CRDT- 2026/08/26 19:17 PHST- 2026/03/12 00:00 [received] PHST- 2026/07/31 00:00 [revised] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/08/26 23:35 [pubmed] PHST- 2026/08/26 23:35 [medline] PHST- 2026/08/26 19:17 [entrez] AID - S1081-1206(26)00413-8 [pii] AID - 10.1016/j.anai.2026.08.017 [doi] PST - aheadofprint SO - Ann Allergy Asthma Immunol. 2026 Aug 26:S1081-1206(26)00413-8. doi: 10.1016/j.anai.2026.08.017. PMID- 42648644 OWN - NLM STAT- MEDLINE DCOM- 20261005 LR - 20261028 IS - 1938-3207 (Electronic) IS - 0002-9165 (Linking) VI - 124 IP - 4 DP - 2026 Oct TI - Construct validity of the Planetary Health Diet Index relative to global food group-based measures of a healthy diet: a multicountry analysis of 24-hour dietary intake data on the FAO/WHO Global Individual Food Consumption Data Tool. PG - 101495 LID - S0002-9165(26)00304-7 [pii] LID - 10.1016/j.ajcnut.2026.101495 [doi] AB - BACKGROUND: The Planetary Health Diet Index (PHDI) was developed as a measure of adherence to the Planetary Health Diet proposed by the EAT-Lancet Commissions; however, its construct validity for accurately reflecting a healthy diet as compared with other global dietary measures remain to be evaluated. OBJECTIVES: The construct validity of PHDI was assessed by comparing the strength of its associations with reference metrics of nutrient adequacy and moderation of foods associated with greater risks of diet-related noncommunicable diseases against food group diversity score (FGDS) and Global Diet Quality Score (GDQS), and its positive (GDQS+) and negative (GDQS-) submetrics. METHODS: Cross-sectional quantitative 24-h recall and food record data from 152,004 nonpregnant females and males (>/=15 y) from 45 surveys in 26 countries accessed from the FAO/WHO Global Individual Food Consumption Data Tool were analyzed. Multilevel linear and modified Poisson regression models quantified associations between PHDI, FGDS, GDQS+, and GDQS- with reference measures [e.g., mean adequacy ratio (MAR), % energy from ultraprocessed food (UPF)] or indicators of a healthy diet [e.g., >/=400 g/d of fruits and vegetables (F&V)], respectively. RESULTS: Adherence to PHDI was highest in low income (LIC) and lower-middle income countries (LMIC), and lowest in upper-middle income (UMIC) and high income countries (HIC). One-SD increments in PHDI were associated with higher MAR beta: 5.49 percentage points [pp]; [95% confidence interval (CI): 3.65 pp, 7.33 pp] in LIC to beta: 1.41 pp [95% CI: 1.23 pp, 1.58 pp] in UMIC, appropriate F&V intakes [relative risk (RR): 2.41 (95% CI: 1.85, 2.49) in UMIC to RR: 1.19 (95% CI: 1.05, 1.34) in LMIC], lower unprocessed red meat [beta: -10.0 g/d (95% CI: -11.4 g/d, -8.73 g/d) in LIC to beta: -6.86 g/d (95% CI: -7.54 g/d, -6.17 g/d) in UMIC], and lower proportions of energy from UPF [beta: -2.47 pp (95% CI: -3.77 pp, -1.18 pp) in LMIC to beta: -1.21 pp (95% CI: -2.32 pp, 0.105 pp) in LIC]; however, 1-SD increases in FGDS and GDQS+ outperformed PHDI in predicting measures of nutrient adequacy, particularly MAR [beta for FGDS: 11.2 pp (95% CI: 9.13 pp, 13.3 pp) in LIC to beta for FGDS: 8.57 pp (95% CI: 8.42 pp, 8.72 pp) in UMIC; beta for GDQS+: 9.82 pp (95% CI: 7.26 pp, 12.4 pp) in LMIC to beta for GDQS+: 7.18 pp (95% CI: 6.00 pp, 8.36 pp) in HIC] and appropriate F&V intakes [RR for FGDS: 2.78 (95% CI: 2.26, 3.41) in LMIC to RR for FGDS: 1.63 (95% CI: 1.22, 2.19) in HIC; RR for GDQS+: 2.39 (95% CI: 1.89, 2.89) in LMIC to RR for GDQS+: 1.55 (95% CI: 1.16, 1.96) in LIC]. CONCLUSIONS: PHDI may serve as a robust, dual-purpose measure for monitoring adherence to diets that are both sustainable and healthy in contexts with regular quantitative dietary intake assessments and low burdens of diet-related undernutrition. However, simpler food group-based measures, such as the FGDS, often show stronger associations with healthy diet subconstructs, such as nutrient adequacy, and are more feasible for large-scale, routine monitoring of diets. CI - Copyright (c) 2026 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Hanley-Cook, Giles T AU - Hanley-Cook GT AD - Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium. Electronic address: giles.hanleycook@ugent.be. FAU - van der Meulen, Emma AU - van der Meulen E AD - Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium. FAU - Beal, Ty AU - Beal T AD - Global Alliance for Improved Nutrition, Washington, DC, United States. FAU - Cacau, Leandro Teixeira AU - Cacau LT AD - Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil; Center for Epidemiological Research in Nutrition and Health, University of Sao Paulo, Sao Paulo, Brazil. LA - eng PT - Journal Article PT - Validation Study DEP - 20260826 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Humans MH - Female MH - *Diet, Healthy MH - Male MH - Cross-Sectional Studies MH - World Health Organization MH - Adult MH - Adolescent MH - Diet Records MH - Young Adult MH - Global Health MH - *Diet Surveys MH - Middle Aged MH - Diet MH - Energy Intake MH - Feeding Behavior OTO - NOTNLM OT - GDQS OT - MDD-W OT - Planetary Health Diet OT - dietary diversity OT - fruit and vegetable intake OT - moderation OT - nutrient adequacy OT - ultraprocessed foods OT - unprocessed red meat COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/08/26 23:35 MHDA- 2026/10/05 23:29 CRDT- 2026/08/26 19:15 PHST- 2025/11/08 00:00 [received] PHST- 2026/08/07 00:00 [revised] PHST- 2026/08/21 00:00 [accepted] PHST- 2026/10/05 23:29 [medline] PHST- 2026/08/26 23:35 [pubmed] PHST- 2026/08/26 19:15 [entrez] AID - S0002-9165(26)00304-7 [pii] AID - 10.1016/j.ajcnut.2026.101495 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Oct;124(4):101495. doi: 10.1016/j.ajcnut.2026.101495. Epub 2026 Aug 26. PMID- 42647367 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260826 LR - 20260828 IS - 2411-5142 (Electronic) IS - 2411-5142 (Linking) VI - 11 IP - 3 DP - 2026 Aug 22 TI - Comparison of Anthropometric Equations to Estimate Body Composition in Chilean Male Adolescent Soccer Players. LID - 10.3390/jfmk11030326 [doi] LID - 326 AB - Background: Anthropometric body-composition assessment in youth soccer commonly relies on equations developed in different source populations and based on distinct body-composition models, potentially altering nutritional and sport-related interpretation. This study compared body-fat estimates from equations intended to report the same outcome, body fat percentage, but based on different operational models, and quantified muscle-mass outputs from anthropometric approaches targeting total-body skeletal, whole-body, and tissue-level muscle compartments in a cohort of Chilean male U-15 and U-16 players. Methods: This secondary cross-sectional method-comparison study analyzed anonymized anthropometric records collected in 2018 from 50 male players. Slaughter, Faulkner, Carter, Deurenberg, and Sloan-Siri estimates of body fat were compared, together with Poortmans, Lee, Doupe, and Kerr muscle-mass approaches. Absolute agreement among adiposity equations was evaluated using a two-way random-effects, absolute-agreement, single-measure ICC [ICC(A,1)] and Bland-Altman analyses. Muscle-mass approaches were compared with repeated-measures analysis; pairwise difference-versus-mean summaries across different muscle constructs were interpreted descriptively rather than as formal agreement tests. Sensitivity analyses excluded Deurenberg and examined a maturation-related Slaughter scenario. Results: Deurenberg yielded the highest body-fat estimate (18.97 +/- 3.07%), followed by Slaughter (13.32 +/- 3.35%), Faulkner (10.84 +/- 1.40%), Sloan-Siri (8.01 +/- 2.80%), and Carter (7.91 +/- 1.49%). Global differences were large (chi(2)(4) = 182.96; p < 0.001; Kendall's W = 0.915), and individual absolute agreement was low [ICC(A,1) = 0.157; bootstrap 95% CI 0.102-0.212]. Excluding Deurenberg did not remove the between-method differences (chi(2)(3) = 124.44; p < 0.001; W = 0.830). For muscle mass, mean estimates ranged from 25.11 +/- 3.07 kg with Poortmans to 31.26 +/- 4.94 kg with Doupe, with a significant method effect after Greenhouse-Geisser correction (p < 0.001). Conclusions: The adiposity equations yielded substantially different numerical estimates of the same reported outcome, body fat percentage, and showed low individual-level absolute agreement. Muscle-mass approaches also produced large numerical differences, partly expected because they target different compartments. Outputs from different equations or constructs should not be treated as numerically interchangeable. Because no criterion reference method was included, this study quantifies method dependence rather than validity and cannot identify the most accurate equation. FAU - Farfan-Diaz, Alvaro AU - Farfan-Diaz A AUID- ORCID: 0009-0000-2435-0185 AD - Carrera de Nutricion y Dietetica, Facultad de Ciencias de la Salud, Universidad de Tarapaca, Arica 1000000, Chile. FAU - Alarcon-Rivera, Miguel AU - Alarcon-Rivera M AUID- ORCID: 0000-0001-8341-5567 AD - Escuela de Ciencias del Deporte y Actividad Fisica, Facultad de Salud, Universidad Santo Tomas, Talca 3460000, Chile. FAU - Andrade Oyarzun, Marcelo AU - Andrade Oyarzun M AUID- ORCID: 0009-0008-9430-2646 AD - Departamento de Nutricion y Dietetica, Universidad de Magallanes, Punta Arenas 6210427, Chile. AD - Centro Asistencial de Docencia e Investigacion, Universidad de Magallanes (CADI-UMAG), Punta Arenas 6210427, Chile. FAU - Tapia-Villanueva, Daniel AU - Tapia-Villanueva D AUID- ORCID: 0009-0005-8414-7791 AD - Independent Researcher, Santiago 8320000, Chile. FAU - Garcia-Carrillo, Exal AU - Garcia-Carrillo E AUID- ORCID: 0000-0001-6190-938X AD - Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca 3480112, Chile. AD - Department of Physical Activity Sciences, Universidad de Los Lagos, Osorno 5290000, Chile. FAU - Molina-Marquez, Ivan AU - Molina-Marquez I AUID- ORCID: 0000-0001-6003-5107 AD - Pedagogia en Educacion Fisica, Facultad de Educacion, Universidad Adventista de Chile, Chillan 3780000, Chile. AD - Programa Doctorado en Ciencias de la Actividad Fisica, Universidad Catolica del Maule, Talca 3460000, Chile. FAU - Yanez-Sepulveda, Rodrigo AU - Yanez-Sepulveda R AUID- ORCID: 0000-0002-9311-6576 AD - Escuela de Ciencias del Deporte, Facultad de Educacion y Humanidades, Universidad Andres Bello, Vina del Mar 2200055, Chile. AD - School of Medicine, Universidad Espiritu Santo, Samborondon 092301, Ecuador. FAU - Barrera-Gonzalez, Dario AU - Barrera-Gonzalez D AUID- ORCID: 0000-0003-4799-341X AD - Carrera de Kinesiologia, Facultad de Ciencias de la Salud, Universidad Autonoma de Chile, Talca 3460000, Chile. FAU - Montalva-Valenzuela, Felipe AU - Montalva-Valenzuela F AUID- ORCID: 0000-0003-0004-3089 AD - Escuela de Entrenador en Actividad Fisica y Deporte, Facultad de Ciencias Humanas, Universidad Bernardo O'Higgins, Santiago 8370993, Chile. LA - eng PT - Journal Article DEP - 20260822 PL - Switzerland TA - J Funct Morphol Kinesiol JT - Journal of functional morphology and kinesiology JID - 101712257 PMC - PMC13511747 OTO - NOTNLM OT - adiposity OT - body composition OT - kinanthropometry OT - method comparison OT - skeletal muscle OT - youth soccer COIS- The authors declare no conflicts of interest. EDAT- 2026/08/26 17:37 MHDA- 2026/08/26 17:38 PMCR- 2026/08/22 CRDT- 2026/08/26 12:54 PHST- 2026/07/17 00:00 [received] PHST- 2026/08/14 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/08/26 17:38 [medline] PHST- 2026/08/26 17:37 [pubmed] PHST- 2026/08/26 12:54 [entrez] PHST- 2026/08/22 00:00 [pmc-release] AID - jfmk11030326 [pii] AID - jfmk-11-00326 [pii] AID - 10.3390/jfmk11030326 [doi] PST - epublish SO - J Funct Morphol Kinesiol. 2026 Aug 22;11(3):326. doi: 10.3390/jfmk11030326. PMID- 42646535 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260826 LR - 20260828 IS - 2039-4403 (Electronic) IS - 2039-439X (Print) IS - 2039-439X (Linking) VI - 16 IP - 8 DP - 2026 Aug 4 TI - Development of Thai-Specific Gestational Weight Gain Targets Using Asian BMI Cut-Points: Implications for Nursing and Midwifery Practice in Preventing Gestational Diabetes Mellitus. LID - 10.3390/nursrep16080274 [doi] LID - 274 AB - Background: Thai obstetric nurses follow WHO gestational weight gain (GWG) guidelines to prevent gestational diabetes mellitus (GDM). However, these Western-derived guidelines misclassify approximately 16% of Thai pregnant women, who carry excess metabolic risk at lower BMI values than Western populations. Objectives: To derive and validate Thai-specific GWG targets using Thai BMI cut-points across five BMI subgroups and assess implications for nursing practice in GDM prevention. Methods: Retrospective cohort study of 1396 Thai singleton pregnancies at a maternal and child hospital (2023-2025). GWG targets were derived as interquartile ranges (P25-P75) from a healthy-outcomes subgroup (n = 706), with validity confirmed by multivariable logistic regression and a 70:30 derivation/validation split. Results: GDM prevalence was 15.8%, with a rising crude trend that was attenuated after accounting for a mid-study change in screening protocol. Provisional Thai-specific GWG targets were underweight/normal weight 11.5-18.0 kg, overweight 9.7-18.0 kg, obesity class I 9.1-16.0 kg, and obesity class II+ 5.8-12.1 kg. Inadequate GWG in obesity class I was associated with a 3.92-fold GDM risk increase (aOR 3.92, 95% CI 2.12-7.24, p < 0.001). Adherence improved from 34.7% (IOM 2009) to 50.2% with Thai-specific targets. Conclusions: These Thai-specific GWG targets are provisional, single-centre pilot estimates. They appear clinically safe and are substantially more achievable than IOM 2009 criteria and are offered to inform BMI-appropriate antenatal counselling and to justify a multi-centre validation study, rather than as ranges that are ready for immediate national adoption. FAU - Xuto, Piyanut AU - Xuto P AUID- ORCID: 0000-0003-1338-0789 AD - Faculty of Nursing, Chiang Mai University, 110/406 Intawaroros rd., Suthep, Muang, Chiang Mai 50200, Thailand. FAU - Bressington, Daniel AU - Bressington D AUID- ORCID: 0000-0003-0951-2208 AD - Faculty of Nursing, Chiang Mai University, 110/406 Intawaroros rd., Suthep, Muang, Chiang Mai 50200, Thailand. FAU - Khiaokham, Lawitra AU - Khiaokham L AUID- ORCID: 0000-0002-4008-5446 AD - Faculty of Nursing, Chiang Mai University, 110/406 Intawaroros rd., Suthep, Muang, Chiang Mai 50200, Thailand. FAU - Khaw-On, Patompong AU - Khaw-On P AUID- ORCID: 0000-0002-9965-5319 AD - Faculty of Nursing, Chiang Mai University, 110/406 Intawaroros rd., Suthep, Muang, Chiang Mai 50200, Thailand. FAU - Matayaboon, Nantarat AU - Matayaboon N AUID- ORCID: 0009-0002-9365-0733 AD - Faculty of Nursing, Chiang Mai University, 110/406 Intawaroros rd., Suthep, Muang, Chiang Mai 50200, Thailand. FAU - Sangsawang, Suraphan AU - Sangsawang S AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. FAU - Janta, Nantawan AU - Janta N AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. FAU - Sungplipan, Pradab AU - Sungplipan P AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. FAU - Wiangsuwan, Suratsawadee AU - Wiangsuwan S AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. FAU - Chaiwatthanakorn, Sujitra AU - Chaiwatthanakorn S AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. FAU - Phiwon, Ampaporn AU - Phiwon A AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. FAU - Khetwang, Kamonchanok AU - Khetwang K AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. FAU - Charuloedphong, Ratchaneewan AU - Charuloedphong R AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. LA - eng GR - The Chiang Mai University International Visiting Professor Fellowship scheme./Chiang Mai University/ PT - Journal Article DEP - 20260804 PL - Switzerland TA - Nurs Rep JT - Nursing reports (Pavia, Italy) JID - 101592662 PMC - PMC13516527 OTO - NOTNLM OT - Asian populations OT - antenatal care OT - body mass index OT - gestational diabetes mellitus OT - gestational weight gain OT - midwifery OT - nursing COIS- The authors declare no conflicts of interest. EDAT- 2026/08/26 17:37 MHDA- 2026/08/26 17:38 PMCR- 2026/08/04 CRDT- 2026/08/26 11:31 PHST- 2026/06/22 00:00 [received] PHST- 2026/07/26 00:00 [revised] PHST- 2026/07/31 00:00 [accepted] PHST- 2026/08/26 17:38 [medline] PHST- 2026/08/26 17:37 [pubmed] PHST- 2026/08/26 11:31 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - nursrep16080274 [pii] AID - nursrep-16-00274 [pii] AID - 10.3390/nursrep16080274 [doi] PST - epublish SO - Nurs Rep. 2026 Aug 4;16(8):274. doi: 10.3390/nursrep16080274. PMID- 42644700 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260826 IS - 1938-2359 (Electronic) IS - 0090-4481 (Linking) VI - 55 IP - 8 DP - 2026 Aug TI - Structured Approach to Pediatric Acute Gastroenteritis: Discussion of Diagnostics and Treatment of Acute Gastroenteritis in Children. PG - e323-e327 LID - 10.3928/19382359-20260609-05 [doi] AB - Pediatric acute gastroenteritis remains a leading global cause of mortality and malnutrition, accounting for 1.7 billion annual cases. Despite its prevalence, management remains variable. This article advocates for a transition from unstructured clinical "gestalt" to evidence-based frameworks in order to improve outcomes. Diagnostic evaluation should prioritize validated tools, like the Clinical Dehydration Scale and the Gorelick Scale, as physician intuition often lacks precision. Laboratory diagnostics and polymerase chain reaction testing should be reserved for severe cases or patients with high risk to avoid over testing. Management emphasizes oral rehydration therapy as the gold standard for mild-to-moderate dehydration, supported by single-dose ondansetron to reduce intravenous (IV) fluid reliance and hospitalization. Antimicrobials are indicated only for specific pathogens (eg, Shigella, Vibrio cholerae) or immunocompromised hosts. Finally, there is discussion on systemic health disparities-noting that children who are Black and not Hispanic and children who are Hispanic are statistically less likely to receive IV fluids or admission-underscoring the role of standardized guidelines in ensuring equitable, high-value care. FAU - Traisman, Benjamin AU - Traisman B AD - Department of Pediatric Hospital Medicine, Ann and Robert H. Lurie Children's Hospital. FAU - Kilaru, Raga AU - Kilaru R AD - Department of Pediatric Hospital Medicine, Ann and Robert H. Lurie Children's Hospital. FAU - Parikh, Sonia AU - Parikh S AD - Department of Pediatric Hospital Medicine, Ann and Robert H. Lurie Children's Hospital. FAU - Listernick, Zoe AU - Listernick Z AD - Department of Pediatric Hospital Medicine, Ann and Robert H. Lurie Children's Hospital. AD - Northwestern University Feinberg School of Medicine, Chicago, Illinois. LA - eng PT - Journal Article PT - Review DEP - 20260801 PL - United States TA - Pediatr Ann JT - Pediatric annals JID - 0356657 SB - IM MH - Humans MH - *Gastroenteritis/diagnosis/therapy/complications MH - Acute Disease MH - Fluid Therapy/methods MH - Dehydration/therapy/etiology/diagnosis MH - Child COIS- Disclosure: The authors have disclosed no potential conflicts of interest, financial or otherwise. EDAT- 2026/08/26 11:50 MHDA- 2026/08/26 11:51 CRDT- 2026/08/26 09:46 PHST- 2026/08/26 11:51 [medline] PHST- 2026/08/26 11:50 [pubmed] PHST- 2026/08/26 09:46 [entrez] AID - 10.3928/19382359-20260609-05 [doi] PST - ppublish SO - Pediatr Ann. 2026 Aug;55(8):e323-e327. doi: 10.3928/19382359-20260609-05. Epub 2026 Aug 1. PMID- 42643824 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260826 LR - 20260827 IS - 2383-1219 (Electronic) IS - 2345-5152 (Print) IS - 2345-5152 (Linking) VI - 13 IP - 3 DP - 2026 Jul TI - The Correlations between Spatial Equality and School Environment with Children's Physical Activity Levels: The Mediating Role of Motivation toward Physical Education. PG - 196-204 LID - 10.30476/intjsh.2026.109473.1592 [doi] AB - BACKGROUND: Children's engagement in physical activity (PA) is influenced by a combination of environmental and psychological factors. The present study aimed to investigate the correlation of spatial equality and the school environment with children's PA levels, given the mediating role of motivation toward physical education (PE). METHODS: A cross-sectional survey was conducted in 2024 in Gorgan, Iran, involving 384 middle-school students (mean age=13.1+/-0.9 years; 194 (50.5%) female and 190 (49.5%) male students). The study participants completed validated questionnaires assessing spatial equality (NEWS-Y), the school environment (SPAEQ), motivation for PE (PEMS), and PA levels (PAQ-C). Structural equation modeling (SEM) was used to investigate both direct and indirect correlations between the variables of the study. RESULTS: Boys exhibited significantly higher levels of PA (M=3.38+/-0.70) compared with girls (M=3.18+/-0.73; P=0.012). Both spatial equality and the school environment were positively correlated with motivation for PE (r=0.62, P<0.001; r=0.59, P<0.001, respectively) and with PA (r=0.48, P<0.001; r=0.51, P<0.001, respectively). SEM results revealed significant correlations of spatial equality (beta=0.14, P=0.005) and the school environment (beta=0.18, P<0.001) with PA, with motivation toward PE acting as a partial mediator (indirect beta=0.15-0.22, P<0.001). CONCLUSIONS: The study results underscored the importance of comprehensive school interventions that integrate equitable infrastructure aimed at enhancing student motivation, thereby encouraging the development of lifelong habits of PA. CI - Copyright: (c) International Journal of School Health. FAU - Monadi, Aref AU - Monadi A AD - Department of Urban Engineering, Faculty of Architecture and Urban Design, Sooreh International University, Tehran, Iran. FAU - Dana, Amir AU - Dana A AD - Department of Physical Education, Ta.C, Islamic Azad University, Tabriz, Iran. FAU - Ghorbani, Saeed AU - Ghorbani S AD - Department of Physical Education, Isl.C., Islamic Azad University, Islamshahr, Iran. LA - eng PT - Journal Article DEP - 20260701 PL - Iran TA - Int J Sch Health JT - International journal of school health JID - 101702483 PMC - PMC13504179 OTO - NOTNLM OT - Environment OT - Exercise OT - Motivation OT - Schools OT - Spatial Equality COIS- None declared. EDAT- 2026/08/26 11:50 MHDA- 2026/08/26 11:51 PMCR- 2026/07/01 CRDT- 2026/08/26 06:18 PHST- 2025/11/02 00:00 [received] PHST- 2025/12/17 00:00 [revised] PHST- 2026/01/04 00:00 [accepted] PHST- 2026/08/26 11:51 [medline] PHST- 2026/08/26 11:50 [pubmed] PHST- 2026/08/26 06:18 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - intjsh-13-3 [pii] AID - 10.30476/intjsh.2026.109473.1592 [doi] PST - epublish SO - Int J Sch Health. 2026 Jul 1;13(3):196-204. doi: 10.30476/intjsh.2026.109473.1592. eCollection 2026 Jul. PMID- 42642883 OWN - NLM STAT- Publisher LR - 20260907 IS - 2151-4658 (Electronic) IS - 2151-464X (Linking) DP - 2026 Aug 25 TI - Validation of Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Measures for Children With Chronic Nonbacterial Osteomyelitis. LID - 10.1002/acr.80146 [doi] AB - OBJECTIVE: To assess the validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric measures in patients with chronic nonbacterial osteomyelitis (CNO). METHODS: Within the longitudinal patient registry of CNO, English-speaking patients aged 8 years and older self-reported PROMIS Pediatric measures of fatigue, pain interference (PI), pain behavior (PB), mobility, upper extremity (UE), physical activity (PA), and strength impact (SI), and external validation measures. Log-transformed linear mixed-effects models with random patient intercepts were used to assess PROMIS T-score changes. Wilcoxon signed-rank test was performed to determine the PROMIS T-score changes among the improved, worsened, and unchanged groups. Spearman rank correlation test determined the relationship of PROMIS T-scores with disease status reported by patients/families. RESULTS: More than 1,000 clinical visits from 184 patients included PROMIS Pediatric measures entries. All PROMIS T-scores correlated significantly (P < 0.01) with patient-reported variables and physician global assessment (PHGA). The correlation between function and mobility, PB, and PI was good (r = 0.4-0.6). The correlation of patient-reported disease status was strong with PHGA (r = 0.75); moderate with mobility, PB, and PI; and weak with fatigue, SI, UE, and PA. The changes of PROMIS T-scores over time for mobility, PB, PA, and PI compared with the self-reported status change were significant (P < 0.05). After effective treatment, when clinical disease activity score improved by at least three points (n = 18), the change of PROMIS T-scores for mobility, PB, PI, and UE were significant (P < 0.05). CONCLUSION: This study provided evidence supporting the use of PROMIS Pediatric mobility, PB, and PI measures for CNO clinical disease monitoring. CI - (c) 2026 The Author(s). Arthritis Care & Research published by Wiley Periodicals LLC on behalf of American College of Rheumatology. FAU - Eckert, Mary M AU - Eckert MM AUID- ORCID: 0009-0000-2105-5025 AD - Western University of Health Sciences, Lebanon, Oregon. AD - Seattle Children's Hospital, Seattle, Washington. FAU - Wu, Eveline Y AU - Wu EY AUID- ORCID: 0000-0002-6394-6843 AD - The University of North Carolina at Chapel Hill. FAU - Oliver, Melissa AU - Oliver M AUID- ORCID: 0000-0002-7689-2573 AD - Indiana University School of Medicine, Indianapolis. FAU - Scheck, Joshua AU - Scheck J AD - Seattle Children's Hospital, Seattle, Washington. FAU - Lapidus, Sivia AU - Lapidus S AUID- ORCID: 0000-0001-8452-9937 AD - Joseph M. Sanzari Children's Hospital, Hackensack, New Jersey. AD - Hackensack University Medical Center, Hackensack, New Jersey. AD - Hackensack Meridian School of Medicine, Hackensack, New Jersey. FAU - Akca, Ummusen Kaya AU - Akca UK AUID- ORCID: 0000-0002-0426-9432 AD - Hacettepe University, Pediatric Rheumatology, Ankara, Turkey. FAU - Yasin, Shima AU - Yasin S AD - University of Iowa Carver College of Medicine, Iowa City. FAU - Lenert, Aleksander AU - Lenert A AUID- ORCID: 0000-0003-2129-3263 AD - University of Iowa Carver College of Medicine, Iowa City. FAU - Stern, Sara AU - Stern S AD - University of Utah, Salt Lake City. FAU - Insalaco, Antonella AU - Insalaco A AD - IRCCS Ospedale Pediatrico Bambino Gesu, Rheumatology, Rome, Italy. AD - ERN RITA Center, Rheumatology, Rome, Italy. FAU - Pardeo, Manuela AU - Pardeo M AUID- ORCID: 0000-0003-0850-7351 AD - IRCCS Ospedale Pediatrico Bambino Gesu, Rheumatology, Rome, Italy. AD - ERN RITA Center, Rheumatology, Rome, Italy. FAU - Simonini, Gabriele AU - Simonini G AD - AOU Meyer Children's Hospital, Rheumatology, Florence, Italy. AD - ERN ReCONNET Center, Rheumatology, Florence, Italy. FAU - Marrani, Edoardo AU - Marrani E AD - AOU Meyer Children's Hospital, Rheumatology, Florence, Italy. FAU - Wang, Xing AU - Wang X AD - Seattle Children's Research Institute, Seattle, Washington. FAU - Huang, Bin AU - Huang B AUID- ORCID: 0000-0001-9724-675X AD - Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. AD - University of Cincinnati College of Medicine, Cincinnati, Ohio. FAU - Kovalick, Leonard K AU - Kovalick LK AD - The University of North Carolina at Chapel Hill. FAU - Rosenwasser, Natalie AU - Rosenwasser N AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Balay-Destrude, Erin AU - Balay-Destrude E AUID- ORCID: 0000-0001-6235-1947 AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Casselman, Gabriel AU - Casselman G AUID- ORCID: 0000-0001-6950-7502 AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Liau, Adriel AU - Liau A AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Klein, Ava AU - Klein A AD - Seattle Children's Hospital, Seattle, Washington. FAU - Shao, Yurong AU - Shao Y AD - Seattle Children's Hospital, Seattle, Washington. FAU - Yang, Claire AU - Yang C AUID- ORCID: 0000-0001-6822-0518 AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Briggs, Molly AU - Briggs M AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Mueller, Ethan AU - Mueller E AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Deng, Emily AU - Deng E AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Trunnell, Paige Rhiannon AU - Trunnell PR AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Hamilton, Iris AU - Hamilton I AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Machrone, Elise AU - Machrone E AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Mosa, Doaa Mosad AU - Mosa DM AD - Mansoura University Hospitals, Rheumatology, Rehabilitation, Mansoura, Egypt. AD - Mansoura University, Rheumatology, Rehabilitation, Mansoura, Egypt. FAU - Tucker, Lori AU - Tucker L AUID- ORCID: 0000-0002-4314-6750 AD - BC Children's Hospital, Rheumatology, Vancouver, British Columbia, Canada. AD - University of British Columbia, Rheumatology, Vancouver, British Columbia, Canada. FAU - Girschick, Hermann AU - Girschick H AUID- ORCID: 0000-0002-2755-3129 AD - Vivantes Clinic Friedrichshain, Pediatrics, Berlin, Germany. FAU - Laxer, Ronald M AU - Laxer RM AD - The Hospital for Sick Children, Toronto, Ontario, Canada. AD - University of Toronto, Toronto, Ontario, Canada. AD - St Michael's Hospital, Toronto, Ontario, Canada. FAU - Tiller, Georgina AU - Tiller G AD - Royal Children's Hospital, Pediatrics, Melbourne, Victoria, Australia. FAU - Akikusa, Jonathan AU - Akikusa J AD - Royal Children's Hospital, Pediatrics, Melbourne, Victoria, Australia. FAU - Hedrich, Christian M AU - Hedrich CM AUID- ORCID: 0000-0002-1295-6179 AD - Alder Hey Children's NHS Foundation Trust, Department of Pediatric Rheumatology, Liverpool, United Kingdom. AD - Department of Women's and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom. FAU - Onel, Karen AU - Onel K AUID- ORCID: 0000-0002-1238-5361 AD - Hospital for Special Surgery, New York, New York. FAU - Dedeoglu, Fatma AU - Dedeoglu F AUID- ORCID: 0000-0002-7516-0848 AD - Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. FAU - Twilt, Marinka AU - Twilt M AUID- ORCID: 0000-0003-1954-2822 AD - Department of Pediatrics, Section of Rheumatology, Alberta Children's Hospital, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. FAU - Ozen, Seza AU - Ozen S AUID- ORCID: 0000-0003-2883-7868 AD - Hacettepe University, Pediatric Rheumatology, Ankara, Turkey. FAU - Ferguson, Polly J AU - Ferguson PJ AD - University of Iowa Carver College of Medicine, Iowa City. FAU - Schanberg, Laura AU - Schanberg L AUID- ORCID: 0000-0002-1913-6472 AD - Duke Clinical Research Institute, Durham, North Carolina. AD - Duke University School of Medicine, Durham, North Carolina. FAU - Reeve, Bryce B AU - Reeve BB AUID- ORCID: 0000-0002-6709-8714 AD - Duke Clinical Research Institute, Durham, North Carolina. AD - Duke University School of Medicine, Durham, North Carolina. FAU - Zhao, Yongdong AU - Zhao Y AUID- ORCID: 0000-0003-3618-1379 AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. LA - eng GR - Kaila Komfort/ PT - Journal Article DEP - 20260825 PL - United States TA - Arthritis Care Res (Hoboken) JT - Arthritis care & research JID - 101518086 SB - IM EDAT- 2026/08/26 05:36 MHDA- 2026/08/26 05:36 CRDT- 2026/08/26 01:02 PHST- 2026/07/27 00:00 [revised] PHST- 2025/11/20 00:00 [received] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/08/26 05:36 [pubmed] PHST- 2026/08/26 05:36 [medline] PHST- 2026/08/26 01:02 [entrez] AID - 10.1002/acr.80146 [doi] PST - aheadofprint SO - Arthritis Care Res (Hoboken). 2026 Aug 25. doi: 10.1002/acr.80146. PMID- 42642511 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260828 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Aug 25 TI - The relationship between problematic media use and their fear, anxiety and behavior during dental treatment in children. LID - 10.1038/s41598-026-63546-4 [doi] LID - 26663 AB - This study aimed to investigate individual, familial, and media-related factors associated with dental fear and anxiety (DFA) and dental behavior management problems (DBMP) in school-age children, with particular emphasis on problematic media use (PMU). In this cross-sectional study, 145 children aged 6-12 years undergoing restorative dental treatment were evaluated. Sociodemographic characteristics, maternal dental anxiety, children's media use characteristics, and PMU were assessed using parental questionnaires and the Problematic Media Use Measure-Short Form (PMUM-SF). Children's dental fear and anxiety were assessed using validated child questionnaires, namely the Children's Fear Survey Schedule-Dental Subscale (CFSS-DS) and the Modified Child Dental Anxiety Scale (MCDASf), while behavior during dental treatment was assessed using the standardized Frankl Rating Scale (FRS). Group comparisons, correlation analyses, and multivariable logistic regression analyses were performed. Dental anxiety and uncooperative behavior during dental treatment were more common among early school-age children than pre-teens (p = 0.011 and p = 0.002, respectively). Maternal dental anxiety was independently associated with uncooperative behavior during dental treatment (AOR = 2.93, 95% CI:1.36-6.30) and dental fear (AOR = 2.86, 95% CI:1.38-5.94). PMUM-SF scores did not differ significantly between children with and without dental anxiety in unadjusted analyses. However, after adjustment for potential confounders, higher PMUM-SF scores were independently associated with dental fear (AOR = 1.07, 95% CI:1.01-1.13). The observed correlations between PMUM-SF scores and dental anxiety-related measures were statistically significant but weak. Younger age and maternal dental anxiety were among the factors most consistently associated with children's dental fear and behavior. Although PMU showed only weak associations with dental anxiety-related outcomes, higher PMUM-SF scores were independently associated with dental fear after adjustment for potential confounders. These findings should be interpreted cautiously and considered exploratory given the cross-sectional design and modest effect sizes. CI - (c) 2026. The Author(s). FAU - Mustuloglu, Seyma AU - Mustuloglu S AUID- ORCID: 0000-0001-9796-4348 AD - Department of Paediatric Dentistry, Faculty of Dentistry, Mersin University, Mersin, Turkey. dtseymaozturk@gmail.com. FAU - Tezol, Ozlem AU - Tezol O AUID- ORCID: 0000-0001-9994-7832 AD - Department of Pediatrics, Faculty of Medicine, Mersin University, Mersin, Turkey. FAU - Yalcin, Siddika Songul AU - Yalcin SS AUID- ORCID: 0000-0001-9061-4281 AD - Department of Social Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260825 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Child MH - Female MH - *Dental Anxiety/psychology/epidemiology MH - Male MH - Cross-Sectional Studies MH - *Child Behavior/psychology MH - Surveys and Questionnaires MH - Media Exposure PMC - PMC13507237 OTO - NOTNLM OT - Behavior Management Problems OT - Children OT - Dental Fear and Anxiety OT - Problematic Media Use OT - Screen Time COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: Mersin University Non-Interventional Clinical Research Ethics Committee's (2022/740) approval was obtained. EDAT- 2026/08/26 05:36 MHDA- 2026/08/26 05:37 PMCR- 2026/08/25 CRDT- 2026/08/25 23:56 PHST- 2026/04/02 00:00 [received] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/08/26 05:37 [medline] PHST- 2026/08/26 05:36 [pubmed] PHST- 2026/08/25 23:56 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - 10.1038/s41598-026-63546-4 [pii] AID - 63546 [pii] AID - 10.1038/s41598-026-63546-4 [doi] PST - epublish SO - Sci Rep. 2026 Aug 25;16(1):26663. doi: 10.1038/s41598-026-63546-4. PMID- 42641818 OWN - NLM STAT- MEDLINE DCOM- 20260906 LR - 20260906 IS - 1874-1754 (Electronic) IS - 0167-5273 (Linking) VI - 463 DP - 2026 Nov 15 TI - Tracking arterial stiffness from childhood to adolescence: the role of adiposity and cardiometabolic factors. PG - 134754 LID - S0167-5273(26)00604-2 [pii] LID - 10.1016/j.ijcard.2026.134754 [doi] AB - BACKGROUND: Carotid-femoral pulse wave velocity (PWV) is the gold standard measure of central arterial stiffness and a predictor of cardiovascular events in adults, with growing relevance in pediatric populations. Although PWV increases naturally with age, cardiometabolic risk factors may accelerate this process. This study compared carotid-femoral PWV between non-overweight and overweight/obese adolescents, evaluated its progression from prepubertal age to early adolescence, and identified independent determinants of arterial stiffness. METHODS: This longitudinal study included 118 participants from the Generation XXI cohort (Porto, Portugal) assessed at ages 8-9 and 13-14 years. Carotid-femoral PWV was measured at both time points using a validated portable device. Anthropometric data, office blood pressure, and fasting blood samples for lipid profile, glucose, and insulin were collected. Body mass index (BMI) classification followed World Health Organization references. RESULTS: PWV increased significantly from childhood to adolescence (5.01 +/- 0.47 to 6.30 +/- 1.05 m/s; p < 0.001). At 13-14 years, overweight/obese adolescents had significantly higher PWV than non-overweight peers. PWV at 13-14 years correlated positively with BMI, BMI z-score, systolic and diastolic blood pressure, and fasting glucose. In adjusted models, PWV at 8-9 years (beta = 0.39; p = 0.039) and BMI z-score at 13-14 years (beta = 0.33; p < 0.001) remained independent predictors of PWV at 13-14 years. CONCLUSIONS: Arterial stiffness in early adolescence reflects both vascular tracking from childhood and concurrent adiposity. These findings support early vascular screening and weight management interventions during key developmental periods to optimize long-term cardiovascular health. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Ventura, Daniela AU - Ventura D AD - Instituto de Ciencias Biomedicas de Abel Salazar, University of Porto, Portugal. FAU - Mosca, Sara AU - Mosca S AD - Instituto de Ciencias Biomedicas de Abel Salazar, University of Porto, Portugal; EPIUnit ITR, Instituto de Saude Publica da Universidade do Porto, University of Porto, Portugal; Pediatric Nephrology Department, Centro Materno-Infantil do Norte, ULS Santo Antonio, Portugal. FAU - Teixeira, Ana AU - Teixeira A AD - EPIUnit ITR, Instituto de Saude Publica da Universidade do Porto, University of Porto, Portugal; Pediatric Nephrology Department, Centro Materno-Infantil do Norte, ULS Santo Antonio, Portugal. FAU - Mota, Claudia AU - Mota C AD - Pediatric Cardiology Department, ULS Sao Joao, Portugal. FAU - Costa, Ana Luisa AU - Costa AL AD - Pediatric Cardiology Department, ULS Sao Joao, Portugal. FAU - Caldas Afonso, Alberto AU - Caldas Afonso A AD - Instituto de Ciencias Biomedicas de Abel Salazar, University of Porto, Portugal; EPIUnit ITR, Instituto de Saude Publica da Universidade do Porto, University of Porto, Portugal; Pediatric Nephrology Department, Centro Materno-Infantil do Norte, ULS Santo Antonio, Portugal. FAU - Correia-Costa, Liane AU - Correia-Costa L AD - Instituto de Ciencias Biomedicas de Abel Salazar, University of Porto, Portugal; EPIUnit ITR, Instituto de Saude Publica da Universidade do Porto, University of Porto, Portugal; Pediatric Nephrology Department, Centro Materno-Infantil do Norte, ULS Santo Antonio, Portugal. Electronic address: lianecosta@icbas.up.pt. LA - eng PT - Journal Article DEP - 20260825 PL - Netherlands TA - Int J Cardiol JT - International journal of cardiology JID - 8200291 SB - IM MH - Humans MH - *Vascular Stiffness/physiology MH - Child MH - Adolescent MH - Female MH - Male MH - Longitudinal Studies MH - *Adiposity/physiology MH - *Cardiometabolic Risk Factors MH - Pulse Wave Analysis/methods MH - Cohort Studies MH - *Cardiovascular Diseases/physiopathology/epidemiology MH - Carotid-Femoral Pulse Wave Velocity/methods MH - Portugal/epidemiology MH - Body Mass Index OTO - NOTNLM OT - Adolescence OT - Arterial stiffness OT - Cardiovascular risk OT - Childhood obesity OT - Pulse wave velocity COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/25 23:33 MHDA- 2026/09/06 23:34 CRDT- 2026/08/25 19:12 PHST- 2026/06/20 00:00 [received] PHST- 2026/08/22 00:00 [revised] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/09/06 23:34 [medline] PHST- 2026/08/25 23:33 [pubmed] PHST- 2026/08/25 19:12 [entrez] AID - S0167-5273(26)00604-2 [pii] AID - 10.1016/j.ijcard.2026.134754 [doi] PST - ppublish SO - Int J Cardiol. 2026 Nov 15;463:134754. doi: 10.1016/j.ijcard.2026.134754. Epub 2026 Aug 25. PMID- 42641368 OWN - NLM STAT- MEDLINE DCOM- 20260831 LR - 20260918 IS - 1532-3099 (Electronic) IS - 0266-6138 (Linking) VI - 162 DP - 2026 Nov TI - Exploring the dose-response relationship between prenatal exercise and postpartum depression: A systematic review and meta-analysis of randomized controlled trials. PG - 104960 LID - S0266-6138(26)00264-0 [pii] LID - 10.1016/j.midw.2026.104960 [doi] AB - IMPORTANCE: Postpartum depression (PPD) is a hidden and widespread global public health crisis affecting millions of mothers and infants annually. Prenatal exercise is a potentially accessible nonpharmacological strategy for PPD prevention, but its optimal dose remains uncertain. OBJECTIVE: To explore the dose-response relationship between prenatal exercise and the incidence of PPD through meta-analysis of randomized controlled trials (RCTs). DATA SOURCES: Systematic searches were conducted in PubMed, Embase, Web of Science, and Cochrane Library using MeSH terms and keywords related to "pregnant women," "prenatal exercise," and "postpartum depression," up to June 23, 2025. STUDY SELECTION: RCTs included examined prenatal exercise interventions in pregnant women without a history of depression, with PPD incidence reported using validated depression scales (such as EPDS, CES-D). Non-RCT studies, duplicate publications, and studies with insufficient data were excluded. DATA EXTRACTION AND SYNTHESIS: Two researchers independently extracted data according to the PRISMA guidelines. A random-effects model was used to pool odds ratios (OR) and their 95% confidence intervals (CI). Linear and nonlinear dose-response models were employed to analyze and evaluate the relationship between exercise dose (measured in METs-min/week) and the incidence of PPD. MAIN OUTCOME(S) AND MEASURE(S): The primary outcome is the incidence of PPD, analyzing its relationship with prenatal exercise dose. RESULTS: Eight RCTs involving 2231 pregnant women were included. The pooled analysis showed that prenatal exercise was associated with a potential reduction in PPD incidence, although the overall effect did not reach statistical significance (OR=0.58, 95% CI [0.33, 1.02]). In dose-stratified analysis, exercise doses >/=500 METs-min/week were associated with significantly lower PPD incidence (OR=0.44, 95% CI [0.24, 0.78]). Subgroup analyses suggested trends toward greater benefits among women aged >/=30 years and those initiating exercise between 14 and 28 weeks of gestation; however, subgroup differences did not reach statistical significance. The linear dose-response trend did not reach statistical significance (p = 0.0533), and neither the overall spline association (p = 0.1704) nor the test for nonlinearity (p = 0.6361) was statistically significant. CONCLUSIONS AND RELEVANCE: Prenatal exercise may be associated with a lower risk of PPD, but the overall pooled effect did not reach statistical significance. Findings concerning >/=500 METs-min/week and the apparent flattening of the dose-response curve should be considered exploratory and require confirmation in larger trials. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Lei, Zhuoling AU - Lei Z AD - School of Physical Education, Southwest University, Chongqing 400715, China; Institute of Motor Quotient, Southwest University, Chongqing 400715, China. FAU - Ma, Pengwei AU - Ma P AD - School of Physical Education, Southwest University, Chongqing 400715, China; Institute of Motor Quotient, Southwest University, Chongqing 400715, China. FAU - Xue, Zhuolin AU - Xue Z AD - School of Physical Education, Southwest University, Chongqing 400715, China; Institute of Motor Quotient, Southwest University, Chongqing 400715, China. FAU - Teo, Eng Wah AU - Teo EW AD - Faculty of Sports and Exercise Science, University of Malaya, Kuala Lumpur 59100, Malaysia. FAU - Li, Junfeng AU - Li J AD - Ministry of Sports, Shandong Technology and Business University, Yantai, 264005, China. Electronic address: 201513386@sdtbu.edu.cn. FAU - Chang, Jindong AU - Chang J AD - School of Physical Education, Southwest University, Chongqing 400715, China; Institute of Motor Quotient, Southwest University, Chongqing 400715, China; Faculty of Sports and Exercise Science, University of Malaya, Kuala Lumpur 59100, Malaysia. Electronic address: changlai@163.com. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260820 PL - Scotland TA - Midwifery JT - Midwifery JID - 8510930 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Randomized Controlled Trials as Topic MH - *Depression, Postpartum/prevention & control/psychology MH - *Exercise/psychology MH - *Prenatal Care/methods/standards OTO - NOTNLM OT - Depression OT - METs OT - Meta-analysis OT - Postpartum depression OT - Prenatal exercise COIS- Declaration of competing interest All authors declare no conflict of interest. EDAT- 2026/08/25 23:33 MHDA- 2026/08/31 23:43 CRDT- 2026/08/25 18:06 PHST- 2025/09/04 00:00 [received] PHST- 2026/08/13 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/08/31 23:43 [medline] PHST- 2026/08/25 23:33 [pubmed] PHST- 2026/08/25 18:06 [entrez] AID - S0266-6138(26)00264-0 [pii] AID - 10.1016/j.midw.2026.104960 [doi] PST - ppublish SO - Midwifery. 2026 Nov;162:104960. doi: 10.1016/j.midw.2026.104960. Epub 2026 Aug 20. PMID- 42640915 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260827 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 8 DP - 2026 TI - Circulating CTRP-1 levels are elevated in women with polycystic ovary syndrome: A case-control study. PG - e0356461 LID - 10.1371/journal.pone.0356461 [doi] LID - e0356461 AB - OBJECTIVE: To investigate circulating C1q/TNF-related protein-1 (CTRP-1) levels in women with polycystic ovary syndrome (PCOS) and evaluate its potential association with metabolic and reproductive features of the syndrome. METHODS: A prospective cross-sectional case-control study was conducted between October 2021 and March 2022 including 96 women (48 with PCOS and 48 controls) aged 15-40 years. PCOS was diagnosed according to the 2003 Rotterdam criteria. Anthropometric measurements and fasting venous blood samples were obtained during the early follicular phase. Serum CTRP-1 levels were measured using enzyme-linked immunosorbent assay (ELISA). Metabolic and hormonal parameters, including HOMA-IR, AMH, and androgen levels, were analyzed. Receiver operating characteristic (ROC) analysis and analysis of covariance (ANCOVA) adjusted for age and body mass index (BMI) were performed. RESULTS: Serum CTRP-1 levels were significantly higher in women with PCOS compared with controls (54.9 +/- 5.2 vs. 26.6 +/- 4.8 ng/mL, p < 0.001). CTRP-1 concentrations were associated with several metabolic and hormonal parameters, including BMI, fasting insulin, triglyceride levels, HDL cholesterol, and AMH. ROC curve analysis demonstrated excellent discriminatory ability within this cohort, although these findings should be interpreted cautiously given the relatively small sample size and case-control design. In multivariable analysis adjusting for age and BMI, CTRP-1 remained independently associated with PCOS (beta = 28.97, p < 0.001). CONCLUSION: Circulating CTRP-1 levels are elevated in women with PCOS and appear to be associated with both metabolic and reproductive characteristics of the syndrome. CTRP-1 may represent a potential biomarker related to metabolic dysregulation in PCOS; however, larger prospective and multicenter studies are required to validate its clinical and diagnostic utility. CI - Copyright: (c) 2026 Ali et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Ali, Cavide AU - Ali C AUID- ORCID: 0000-0001-6188-1516 AD - Department of Obstetrics and Gynecology, Ankara Bilkent City Hospital, Ankara, Turkiye. AD - Obstetrics and Gynecology Clinic, Kadikoy Acibadem Hospital, Istanbul, Turkey. FAU - Sayir, Alper AU - Sayir A AD - Department of Obstetrics and Gynecology, Ankara Bilkent City Hospital, Ankara, Turkiye. FAU - Ocba, Feride AU - Ocba F AD - Department of Obstetrics and Gynecology, Ankara Bilkent City Hospital, Ankara, Turkiye. FAU - Ozturk Atan, Deniz AU - Ozturk Atan D AD - Department of Obstetrics and Gynecology, Ankara Bilkent City Hospital, Ankara, Turkiye. FAU - Harmanci, Melike Sevde AU - Harmanci MS AUID- ORCID: 0000-0002-5629-2036 AD - Department of Obstetrics and Gynecology, Ankara Bilkent City Hospital, Ankara, Turkiye. FAU - Surecek, Mustafa Cem AU - Surecek MC AD - Department of Obstetrics and Gynecology, Canakkale Onsekiz Mart University, Canakkale, Turkiye. FAU - Gulerman, Hacer Cavidan AU - Gulerman HC AD - Department of Obstetrics and Gynecology, Ankara Bilkent City Hospital, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260825 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (C1QTNF1 protein, human) RN - 0 (Biomarkers) RN - 0 (Proteins) SB - IM MH - Humans MH - Female MH - *Polycystic Ovary Syndrome/blood MH - Case-Control Studies MH - Adult MH - Young Adult MH - Adolescent MH - Cross-Sectional Studies MH - Prospective Studies MH - Body Mass Index MH - ROC Curve MH - Biomarkers/blood MH - Proteins PMC - PMC13505912 COIS- The authors have declared that no competing interests exist. EDAT- 2026/08/25 17:35 MHDA- 2026/08/25 17:36 PMCR- 2026/08/25 CRDT- 2026/08/25 13:34 PHST- 2026/04/07 00:00 [received] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/08/25 17:36 [medline] PHST- 2026/08/25 17:35 [pubmed] PHST- 2026/08/25 13:34 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - PONE-D-26-16139 [pii] AID - 10.1371/journal.pone.0356461 [doi] PST - epublish SO - PLoS One. 2026 Aug 25;21(8):e0356461. doi: 10.1371/journal.pone.0356461. eCollection 2026. PMID- 42640905 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260827 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 8 DP - 2026 TI - Identification and risk-factor analysis for individuals at high risk for keratoconus via machine learning and logistic regression. PG - e0354924 LID - 10.1371/journal.pone.0354924 [doi] LID - e0354924 AB - PURPOSE: To evaluate keratoconus (KC) risk factors and to develop a machine-learning (ML) model for KC and myopia classification. METHODS: In this retrospective single-center cross-sectional study, demographic and lifestyle data from patients with KC and individuals from a preoperative refractive surgery clinic were collected from January 20, 2024, to December 1, 2024. Univariable and multivariable regression analyses were used to identify key risk factors. Additionally, random forest (RF)-recursive feature elimination (RFE), extreme gradient boosting (XGBoost)-RFE, and univariable logistic regression were applied to select factors for ML models. Seven ML models were developed for a lifestyle-based classification system, with the performance being validated through discrimination and calibration, and interpretability being improved using SHapley Additive exPlanations (SHAP). RESULTS: Analysis of 711 patients (mean [standard deviation] age, 26.6 [7.1] years; 439 males [61.7%]) revealed 275 with KC. Multivariable regression analysis identified seven risk factors for KC, including male sex, higher body-mass index (BMI), lower education level, more distant childhood residence, allergic conjunctivitis, and increased eye-rubbing intensity and frequency. After feature selection of 24 variables, the neural-network model demonstrated the highest performance (area under the receiver operating characteristic curve [AUROC] = 0.79), followed by RF (AUROC = 0.77) and XGBoost (AUROC = 0.76). SHAP analysis consistently highlighted eye-rubbing intensity, sex, BMI, and childhood residence among the top 10 factors across the top three models, which were also confirmed by univariable logistic regression. CONCLUSION: ML models can distinguish high-risk KC groups based on clinical risk factors, facilitating risk stratification and early lifestyle interventions. CI - Copyright: (c) 2026 Du et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Du, Kaiyue AU - Du K AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. FAU - Peng, Rongmei AU - Peng R AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. FAU - Chen, Yueguo AU - Chen Y AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. FAU - Yuan, Bowei AU - Yuan B AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. FAU - Chen, Wei AU - Chen W AD - Institute of Automation, Chinese Academy of Sciences, Beijing, China. FAU - Han, Liang AU - Han L AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. FAU - Xiao, Gege AU - Xiao G AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. FAU - Qu, Yi AU - Qu Y AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. FAU - Hong, Jing AU - Hong J AUID- ORCID: 0000-0002-8079-2073 AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. LA - eng PT - Journal Article DEP - 20260825 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Keratoconus/epidemiology/etiology/diagnosis MH - Female MH - Risk Factors MH - Male MH - *Machine Learning MH - Logistic Models MH - Retrospective Studies MH - Adult MH - Cross-Sectional Studies MH - Random Forest MH - Boosting Machine Learning Algorithms MH - Predictive Learning Models MH - Classification Algorithms MH - Young Adult PMC - PMC13505905 COIS- The authors have declared that no competing interests exist. EDAT- 2026/08/25 17:35 MHDA- 2026/08/25 17:36 PMCR- 2026/08/25 CRDT- 2026/08/25 13:34 PHST- 2025/06/03 00:00 [received] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/08/25 17:36 [medline] PHST- 2026/08/25 17:35 [pubmed] PHST- 2026/08/25 13:34 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - PONE-D-25-28249 [pii] AID - 10.1371/journal.pone.0354924 [doi] PST - epublish SO - PLoS One. 2026 Aug 25;21(8):e0354924. doi: 10.1371/journal.pone.0354924. eCollection 2026. PMID- 42637091 OWN - NLM STAT- Publisher LR - 20260910 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 228 DP - 2026 Sep 10 TI - Tactile exposure as a strategy for shaping food texture preferences in preschool children - a mixed-methods pilot study. PG - 108765 LID - S0195-6663(26)00327-2 [pii] LID - 10.1016/j.appet.2026.108765 [doi] AB - Food texture, such as the presence of lumps or pieces, is a common reason for food rejection among children. Yet, few strategies exist to support children with narrow texture preferences. This pilot study explored whether tactile exposure to food stimuli could improve children's preferences for food containing particles. Twenty-four children aged 3-6 years with an initial low preference for particulate textures, screened using a validated forced-choice questionnaire, participated in three tactile activities over one week. These included (1) searching for hidden objects in muesli and yoghurt, (2) preparing a yoghurt-fruit mix by cutting and smashing fresh fruits, and (3) matching foods to texture vocabulary in a semantic task. Texture preferences were assessed immediately before and after the activity week using paired preference tests comparing smooth yoghurts with yoghurts containing fruit pieces, and at a one-week follow-up by repeating the questionnaire. Parents were also interviewed regarding their perceptions of the activities. Paired preference tests showed no significant change in children's preference for yoghurt with fruit pieces. However, children's self-reported preferences for foods containing particles increased significantly at follow-up (p = 0.032). Parents responded positively to the activities, and about half reported positive changes in their child's eating behaviours, such as being more explorative, increased acceptance of foods with particles and willingness to try new foods. Overall, these findings support the feasibility of texture-focused activities within this pilot sample and provide examples that could inform future interventions in home or childcare settings. Larger controlled studies are needed to determine their effectiveness. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Chow, Ching Yue AU - Chow CY AD - Section for Design and Consumer Behaviour, Department of Food Science, University of Copenhagen, Denmark; Arla Innovation Centre, Arla Foods AMBA, Denmark. Electronic address: chingyuechow@food.ku.dk. FAU - Bech, Anne C AU - Bech AC AD - Arla Innovation Centre, Arla Foods AMBA, Denmark. FAU - Zeinstra, Gertrude G AU - Zeinstra GG AD - Wageningen Social & Economic Research: Consumer Research Group, Wageningen University & Research, the Netherlands. FAU - Olsen, Annemarie AU - Olsen A AD - Section for Design and Consumer Behaviour, Department of Food Science, University of Copenhagen, Denmark; Department of Psychology, University of Copenhagen, Denmark. FAU - Bredie, Wender L P AU - Bredie WLP AD - Section for Design and Consumer Behaviour, Department of Food Science, University of Copenhagen, Denmark. LA - eng PT - Journal Article DEP - 20260910 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM OTO - NOTNLM OT - Children OT - Food neophobia OT - Food texture OT - Preference OT - Tactile exposure COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Ching Yue Chow reports financial support was provided by Arla Foods amba. Anne C. Bech reports a relationship with Arla Foods amba that includes: employment. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/24 23:34 MHDA- 2026/08/24 23:34 CRDT- 2026/08/24 19:14 PHST- 2026/05/14 00:00 [received] PHST- 2026/08/05 00:00 [revised] PHST- 2026/08/21 00:00 [accepted] PHST- 2026/08/24 23:34 [pubmed] PHST- 2026/08/24 23:34 [medline] PHST- 2026/08/24 19:14 [entrez] AID - S0195-6663(26)00327-2 [pii] AID - 10.1016/j.appet.2026.108765 [doi] PST - aheadofprint SO - Appetite. 2026 Sep 10;228:108765. doi: 10.1016/j.appet.2026.108765. PMID- 42635458 OWN - NLM STAT- Publisher LR - 20260824 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) DP - 2026 Aug 21 TI - Computed Tomography-Based Evaluation of Positional Cranial Deformities in Emergency Department Patients Aged 15 to 39 Years in Japan. LID - 10.1097/SCS.0000000000013294 [doi] AB - Positional cranial deformity due to sustained external pressure during infancy frequently improves in early childhood; however, its prevalence in adulthood, particularly in East Asian populations, remains unclear. The authors performed a retrospective cross-sectional analysis of thin-slice cranial computed tomography (CT) images from 242 Japanese individuals aged 15 to 39 years who underwent cranial CT at a single tertiary hospital from 2014 to 2023 and had no intracranial abnormalities. Using the cranial vault asymmetry index (CVAI) and cephalic index (CI), cranial morphology was measured on standardized reconstructed images. The median CVAI was 3.94 (interquartile range, 1.99-6.28); of the participants, 129 (53.3%) met criteria for plagiocephaly, and 46 (19.0%) had moderate-to-severe deformity. Brachycephaly prevalence was 1.6% using Japanese reference-based criteria but 72.3% using international anthropometric-based criteria. Males exhibited a higher CVAI than females; however, no difference in the CVAI and CI was noted by birth year before versus after introducing Japan's Back-to-Sleep campaign. Both indices demonstrated excellent interrater reliability. The observed prevalence of plagiocephaly in this Japanese emergency department CT cohort indicates that plagiocephaly remains common among Japanese young adults, with a significant proportion exhibiting moderate-to-severe deformity, and that infant sleep positioning practices alone do not fully account for its prevalence. The marked discrepancy between Japanese and international criteria suggests that population-specific reference values may be more appropriate for assessing brachycephaly in Japanese adults. This finding is crucial for counseling caregivers and informing treatment decisions for infants with positional cranial deformities. CI - Copyright (c) 2026 by Mutaz B. Habal, MD. FAU - Inomata, Satomi AU - Inomata S AUID- ORCID: 0000-0001-6571-4264 AD - Division of Neonatology, Maternal and Perinatal Center, Toyama University Hospital. FAU - Kawahara, Yasuhiro AU - Kawahara Y AD - Department of Radiology, Toyama University Hospital. FAU - Tsuritani, Shuhei AU - Tsuritani S AD - Department of Radiology, University of Toyama, Toyama, Japan. FAU - Doai, Mariko AU - Doai M AD - Department of Radiology, University of Toyama, Toyama, Japan. FAU - Kido, Aki AU - Kido A AD - Department of Radiology, University of Toyama, Toyama, Japan. FAU - Kato, Riko AU - Kato R AD - Division of Neonatology, Maternal and Perinatal Center, Toyama University Hospital. FAU - Noguchi, Kyo AU - Noguchi K AD - Department of Radiology, University of Toyama, Toyama, Japan. FAU - Yoshida, Taketoshi AU - Yoshida T AUID- ORCID: 0000-0002-9937-1703 AD - Division of Neonatology, Maternal and Perinatal Center, Toyama University Hospital. LA - eng GR - JPMC_JR_2504/the collaborative research funding from Japan Medical Company Inc., the Charitable Trust Pediatrics Research Promotion Fund/ PT - Journal Article DEP - 20260821 PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 SB - IM OTO - NOTNLM OT - Brachycephaly OT - computed tomography OT - cranial index OT - cranial vault asymmetry index OT - plagiocephaly COIS- S.I., R.K., and T.Y. are clinicians involved in the diagnosis and management of positional cranial deformities, including helmet therapy. The remaining authors report no conflicts of interest. EDAT- 2026/08/24 11:37 MHDA- 2026/08/24 11:37 CRDT- 2026/08/24 09:13 PHST- 2025/12/30 00:00 [received] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/08/24 11:37 [medline] PHST- 2026/08/24 11:37 [pubmed] PHST- 2026/08/24 09:13 [entrez] AID - 00001665-990000000-04524 [pii] AID - 10.1097/SCS.0000000000013294 [doi] PST - aheadofprint SO - J Craniofac Surg. 2026 Aug 21. doi: 10.1097/SCS.0000000000013294. PMID- 42635107 OWN - NLM STAT- Publisher LR - 20260824 IS - 1476-6256 (Electronic) IS - 0002-9262 (Linking) DP - 2026 Aug 24 TI - Improving Dietary Data Quality in Nutrition Studies: Development and Validation of an Explainable, Reproducible, Open Machine Learning-Assisted Framework for Outlier Detection in 24-Hour Recalls. LID - kwag204 [pii] LID - 10.1093/aje/kwag204 [doi] AB - Twenty-four-hour dietary recalls (24HRs) are widely used in nutritional epidemiology, but repeated administration is required to capture within-person variability, introducing temporal dependence and challenges for data cleaning. Existing outlier detection approaches are largely static, manual, and based on adult-centric thresholds, limiting reproducibility and scalability. We developed and validated an explainable, reproducible machine learning (ML)-assisted framework to detect and evaluate implausible intake values in cross-sectional and longitudinal 24HRs and to generate AI-ready dietary datasets. The open pipeline integrates automated statistical detection using digitized National Cancer Institute 5th-95th percentile intake ranges, longitudinal interquartile range-based flagging, and ML-based rule explainability for outlier detection. Validation was conducted using the Microbiota, Growth, and Diet (MiGrowD) study in Ontario, Canada (126 children aged 8-12 years), and data from the 2015 Canadian Community Health Survey-Nutrition, a nationally representative sample of Canadian children and adults with repeated 24HRs (n = 15 216). Across energy intake and seven nutrients, 75 recalls containing at least one potentially implausible value were identified. In longitudinal data, the framework achieved > 77% sensitivity, 97% specificity, and 88% precision, outperforming the static method. This explainable data-driven framework improves data quality, transparency, and reproducibility, supporting scalable epidemiologic analyses using AI-ready dietary data. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. FAU - Massara, Paraskevi AU - Massara P AUID- ORCID: 0000-0003-0906-0985 AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada. FAU - Saab, Stephanie AU - Saab S AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. FAU - Asrar, Arooj AU - Asrar A AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. FAU - Omand, Jessica AU - Omand J AUID- ORCID: 0000-0003-2095-3629 AD - School of Nutrition, Toronto Metropolitan University, Toronto, ON, Canada. FAU - Anderson, Laura N AU - Anderson LN AUID- ORCID: 0000-0002-6106-5073 AD - Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada. FAU - Keown-Stoneman, Charles AU - Keown-Stoneman C AUID- ORCID: 0000-0001-8790-1589 AD - Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada. AD - Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. FAU - Maguire, Jonathon L AU - Maguire JL AUID- ORCID: 0000-0002-4083-8612 AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. AD - Department of Pediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Department of Pediatrics, St. Michael's Hospital, Toronto, ON, Canada. AD - Joannah and Brian Lawson Center for Child Nutrition, University of Toronto, Toronto, ON, Canada. FAU - Bandsma, Robert H J AU - Bandsma RHJ AUID- ORCID: 0000-0001-6358-4750 AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Translational Medicine Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada. FAU - Birken, Catherine S AU - Birken CS AUID- ORCID: 0000-0003-0308-8645 AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada. AD - Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. AD - Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. AD - Department of Pediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Department of Pediatrics, St. Michael's Hospital, Toronto, ON, Canada. AD - Joannah and Brian Lawson Center for Child Nutrition, University of Toronto, Toronto, ON, Canada. FAU - Comelli, Elena M AU - Comelli EM AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Joannah and Brian Lawson Center for Child Nutrition, University of Toronto, Toronto, ON, Canada. LA - eng PT - Journal Article DEP - 20260824 PL - United States TA - Am J Epidemiol JT - American journal of epidemiology JID - 7910653 SB - IM OTO - NOTNLM OT - 24-hour dietary recall OT - AI-ready diet data OT - child and adult nutrition OT - data-driven outlier detection OT - longitudinal diet data EDAT- 2026/08/24 11:37 MHDA- 2026/08/24 11:37 CRDT- 2026/08/24 06:33 PHST- 2026/04/29 00:00 [received] PHST- 2026/08/10 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/08/24 11:37 [medline] PHST- 2026/08/24 11:37 [pubmed] PHST- 2026/08/24 06:33 [entrez] AID - 8769274 [pii] AID - 10.1093/aje/kwag204 [doi] PST - aheadofprint SO - Am J Epidemiol. 2026 Aug 24:kwag204. doi: 10.1093/aje/kwag204. PMID- 42632822 OWN - NLM STAT- Publisher LR - 20260822 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Aug 22 TI - Association between triglyceride-glucose index and elevated blood pressure among U.S. adolescents aged 12-17. LID - 10.1038/s41390-026-05407-4 [doi] AB - BACKGROUND: The triglyceride-glucose (TyG) index is a known cardiovascular risk factor in adults, but its association with elevated blood pressure (EBP) in adolescents remains unclear. We hypothesized that the TyG index is associated with EBP among U.S. adolescents aged 12-17 years. METHODS: This cross-sectional analysis included 4409 adolescents from the National Health and Nutrition Examination Survey (NHANES) 1999-2018. We used weighted multivariate logistic regression, weighted subgroup analysis, threshold effect and smoothing curve fitting to examine the association between the TyG index and EBP. RESULTS: Among the participants, 661 (14.9%) had EBP. After full adjustment, each unit rise in TyG index significantly boosted EBP odds (OR = 4.45, 95% CI 1.34-14.78, P = 0.02). A nonlinear relationship was observed, with an exploratory inflection point of the TyG index at 7.98. In BMI-stratified analyses, the association remained significant only among adolescents with BMI < 25 kg/m(2) (OR 3.09; 95%CI: 1.55-6.18; P < 0.01). Subgroup analyses revealed no significant interactions (all P for interaction >0.05). CONCLUSIONS: TyG index was cross-sectionally associated with EBP in U.S. 12-17-year-olds, with an exploratory inflection point. This suggests a potential low-cost indicator for risk stratification of adolescents with higher odds of EBP, pending verification in longitudinal studies. IMPACT: The triglyceride-glucose (TyG) index is cross-sectionally associated with elevated blood pressure (EBP) in U.S. 12-17-year-old adolescents, with an exploratory inflection point of 7.98. This study explores a TyG index exploratory inflection point for adolescent EBP risk in a nationally representative sample. TyG index, a routine and low-cost biomarker, presents potential utility for early risk stratification of adolescent EBP, although further prospective validation is required. The non-linear TyG index-EBP association highlights the potential need for age-specific metabolic risk stratification in adolescents. CI - (c) 2026. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - Tang, Jiazhong AU - Tang J AD - Department of Pediatric Cardiac Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Shi, Yuexin AU - Shi Y AD - Department of Jinglang International Medical Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Jiao, Xianting AU - Jiao X AD - Department of Pediatric Infectious, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Yang, Ling AU - Yang L AD - Department of Pediatric Cardiac Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Huang, Jihong AU - Huang J AD - Department of Pediatric Cardiac Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Wang, Huiying AU - Wang H AD - Department of Pediatric Cardiac Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 18221403205@163.com. LA - eng PT - Journal Article DEP - 20260822 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Consent statement: NHANES was conducted with approval by the National Center for Health Statistics Ethics Review Board and obtained informed written consent from all the individuals involved in the study. EDAT- 2026/08/23 05:41 MHDA- 2026/08/23 05:41 CRDT- 2026/08/22 23:18 PHST- 2026/02/19 00:00 [received] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/07/07 00:00 [revised] PHST- 2026/08/23 05:41 [medline] PHST- 2026/08/23 05:41 [pubmed] PHST- 2026/08/22 23:18 [entrez] AID - 10.1038/s41390-026-05407-4 [pii] AID - 10.1038/s41390-026-05407-4 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Aug 22. doi: 10.1038/s41390-026-05407-4. PMID- 42628000 OWN - NLM STAT- MEDLINE DCOM- 20260821 LR - 20260914 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Aug 21 TI - Mental Health, Gender Dysphoria, and Quality of Life in Trans Individuals Following Top Surgery: Protocol for a Prospective Cohort Study. PG - e83928 LID - 10.2196/83928 [doi] LID - e83928 AB - BACKGROUND: Top surgery refers to various gender-affirming surgical procedures involving breast or chest tissue. Existing research suggests top surgery improves physical, psychological, and social well-being in transgender and gender-diverse individuals (herein "trans") who desire it. However, most studies have been retrospective, have not used validated outcome measures, and have excluded nonbinary individuals, limiting the robustness of the existing research. OBJECTIVE: This study aims to examine changes in mental health, gender dysphoria, risky behaviors, and quality of life of trans people (including nonbinary individuals) following top surgery. METHODS: Trans individuals aged 16 years and older undergoing top surgery will be recruited from a single surgeon's office in Perth, Western Australia, as part of a longitudinal, prospective cohort study. Questionnaires will be administered to participants at 3 time points: within 8 weeks prior to surgery, 6-8 weeks post surgery, and 1 year post surgery. These questionnaires will collect data on patient demographics, planning and expectations for surgery, support received during surgery access, satisfaction with care received from their surgeon, use of gender-affirming hormones, mental health (ie, anxiety, depression, self-harm and suicide, and mental health diagnoses), gender euphoria and dysphoria, exercise and diet, disordered eating, quality of life, substance use, social acceptance and discrimination, and reflections on the experience and outcomes of their surgery. Patient-reported outcomes will be measured using validated instruments and bespoke items developed through community consultation. Validated instruments include the GENDER-Q (health professional subscale); the Generalized Anxiety Disorder 7-item; the Patient Health Questionnaire-9; the Gender Euphoria Scale; an adapted version of the Olson-Kennedy Chest Dysphoria Scale; the International Physical Activity Questionnaire - Short Form; the Eating Disorder Examination Questionnaire - Short; the Assessment of Quality of Life 8 Dimensions; and the Alcohol, Smoking, and Substance Involvement Screening Test - Short Form. Surgical satisfaction will be assessed using both patient- and surgeon-reported measures, enabling between-group comparisons. Quantitative data will be analyzed using linear regression models and repeated-measures ANOVA to compare outcomes across the 3 time points; qualitative data will undergo a general inductive approach to analysis to produce categories that contextualize and supplement the quantitative findings, as well as identify any novel or unexpected experiences. RESULTS: This study received funding in February 2024. Data collection commenced in May 2025 and is expected to be completed by December 2027. As of February 2026, 26 people have consented to participate. CONCLUSIONS: This study will extend research on the mental health, gender dysphoria, and quality-of-life outcomes of top surgery for trans individuals in Australia. By addressing limitations of existing research, this study aims to improve our understanding of trans people's experience accessing and receiving top surgery. The findings may guide improvements in perioperative and postoperative care and support for patients and inform policy related to gender-affirming surgeries in Australia. CI - (c) Julia Bak, Kah Aik Tan, Jack Ball, Sam Bonney, Julia K Moore, Kirsty Hird, Blake S Cavve, Larissa Marion, Tim Hewitt, Sav Zwickl, Simone Mahfouda, Ashleigh Lin, Penelope Strauss. Originally published in JMIR Research Protocols (https://www.researchprotocols.org). FAU - Bak, Julia AU - Bak J AUID- ORCID: 0009-0005-6822-534X AD - Youth Mental Health, The Kids Research Institute Australia, 15 Hospital Ave, Nedlands WA 6009, Perth, Australia, 61 63191000. FAU - Tan, Kah Aik AU - Tan KA AUID- ORCID: 0000-0002-3053-7154 AD - South Metropolitan Health Service - Mental Health, Fiona Stanley Hospitals Group, Perth, Australia. AD - East Metropolitan Health Service - Mental Health, Royal Perth Bentley Hospitals Group, Perth, Australia. FAU - Ball, Jack AU - Ball J AUID- ORCID: 0009-0006-4726-3723 AD - Youth Mental Health, The Kids Research Institute Australia, 15 Hospital Ave, Nedlands WA 6009, Perth, Australia, 61 63191000. FAU - Bonney, Sam AU - Bonney S AD - Youth Mental Health, The Kids Research Institute Australia, 15 Hospital Ave, Nedlands WA 6009, Perth, Australia, 61 63191000. FAU - Moore, Julia K AU - Moore JK AUID- ORCID: 0000-0002-2313-7048 AD - The Gender Diversity Service, Child and Adolescent Health Service - Mental Health, Perth Children's Hospital, Perth, Australia. FAU - Hird, Kirsty AU - Hird K AUID- ORCID: 0000-0001-7677-2128 AD - The Kids Research Institute Australia, 15 Hospital Ave, Nedlands WA 6009, Perth, Australia. FAU - Cavve, Blake S AU - Cavve BS AUID- ORCID: 0000-0002-3548-6181 AD - Youth Mental Health, The Kids Research Institute Australia, 15 Hospital Ave, Nedlands WA 6009, Perth, Australia, 61 63191000. FAU - Marion, Larissa AU - Marion L AUID- ORCID: 0000-0002-8244-6588 AD - School of Psychological Science, The University of Western Australia, Perth, Australia. FAU - Hewitt, Tim AU - Hewitt T AUID- ORCID: 0009-0003-0989-9470 AD - Fellow of the Royal Australasian College of Surgeons, Perth, Australia. AD - Child and Adolescent Health Service, Perth Children's Hospital, Perth, Australia. FAU - Zwickl, Sav AU - Zwickl S AUID- ORCID: 0000-0003-2959-5928 AD - Youth Mental Health, The Kids Research Institute Australia, 15 Hospital Ave, Nedlands WA 6009, Perth, Australia, 61 63191000. AD - Department of Medicine (Austin Health), Trans Health Research Group, The University of Melbourne, Perth, Australia. FAU - Mahfouda, Simone AU - Mahfouda S AUID- ORCID: 0000-0002-1501-3926 AD - Department of Clinical Psychology, Acute Adult Inpatient Services, Graylands Hospital, Perth, Australia. FAU - Lin, Ashleigh AU - Lin A AUID- ORCID: 0000-0002-4054-0242 AD - School of Population and Global Health, The University of Western Australia, Perth, Australia. AD - Australian Research Centre in Sex, Health and Society, La Trobe University, Melbourne, Australia. FAU - Strauss, Penelope AU - Strauss P AUID- ORCID: 0000-0002-4828-0983 AD - Youth Mental Health, The Kids Research Institute Australia, 15 Hospital Ave, Nedlands WA 6009, Perth, Australia, 61 63191000. AD - School of Population and Global Health, The University of Western Australia, Perth, Australia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260821 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - Male MH - *Quality of Life/psychology MH - Female MH - *Gender Dysphoria/psychology MH - Prospective Studies MH - *Transgender Persons/psychology MH - *Mental Health MH - Surveys and Questionnaires MH - Adult MH - *Gender-Affirming Surgery/psychology MH - Adolescent MH - Western Australia MH - Longitudinal Studies MH - Gender-Nonconforming Persons PMC - PMC13496940 OTO - NOTNLM OT - chest reconstruction OT - gender affirmation OT - gender dysphoria OT - top surgery OT - transgender COIS- Conflicts of Interest: TH is a surgeon who performs top surgery in Western Australia and is a recruitment site for this study. TH contributed to the study design primarily through co-developing the surgical pro formas and informing on the ideal timing of questionnaire delivery for participants. TH will be aware of the identity of participants as he will complete the surgical pro formas for participants. However, TH will not have access to the raw data collected through the participant questionnaires, to preserve participant privacy and ensure that participants feel free to answer the questionnaires freely. EDAT- 2026/08/21 17:37 MHDA- 2026/08/21 17:38 PMCR- 2026/08/21 CRDT- 2026/08/21 15:53 PHST- 2025/09/10 00:00 [received] PHST- 2026/04/20 00:00 [revised] PHST- 2026/04/22 00:00 [accepted] PHST- 2026/08/21 17:38 [medline] PHST- 2026/08/21 17:37 [pubmed] PHST- 2026/08/21 15:53 [entrez] PHST- 2026/08/21 00:00 [pmc-release] AID - v15i1e83928 [pii] AID - 83928 [pii] AID - 10.2196/83928 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Aug 21;15:e83928. doi: 10.2196/83928. PMID- 42627606 OWN - NLM STAT- Publisher LR - 20260821 IS - 1720-8386 (Electronic) IS - 0391-4097 (Linking) DP - 2026 Aug 21 TI - Interpreting the GnRH stimulation test in girls with central precocious puberty: the role of age and body mass index. LID - 10.1007/s40618-026-03027-7 [doi] AB - PURPOSE: The gonadotropin-releasing hormone (GnRH) stimulation test is the reference standard for diagnosing central precocious puberty (CPP), yet its reliability may vary with age and body mass index (BMI). This study evaluated the diagnostic performance of GnRH test parameters in girls with suspected CPP and examined the influence of age and BMI on their clinical interpretation. METHODS: This retrospective study included 98 girls who underwent GnRH stimulation testing between January 2023 and December 2025 at a tertiary pediatric endocrinology center. Auxological data, basal luteinizing hormone (LH), stimulated LH at 40 min (LH(4)(0)), stimulated LH/FSH ratio (sLH/FSH), bone age advancement (BAA), and pelvic ultrasonographic measurements were recorded. Final CPP diagnosis based on longitudinal follow-up served as the reference outcome. ROC analyses, age- and BMI-stratified evaluations, and multivariable logistic regression were performed. RESULTS: Thirty-six girls (36.7%) were diagnosed with CPP, and all initiated GnRHanalogue treatment. LH(4)(0) showed the highest diagnostic performance (AUC = 0.738); a cut-off of 4.65 IU/L yielded 91.2% sensitivity and 61.7% specificity. Basal LH had limited accuracy (AUC = 0.668), and ultrasonographic parameters showed poor discrimination. LH(4)(0) and BAA were independently associated with CPP. Diagnostic performance varied by age, with excellent discrimination in girls < 6 years (AUC = 1.000) and moderate accuracy at 6-8 years (AUC = 0.738). Increasing BMI was associated with reduced discriminatory capacity of LH(4)(0), while uterine length showed relatively higher performance in girls with obesity. CONCLUSION: The diagnostic performance of the GnRH stimulation test varied with age and BMI and was lower in older girls and those with obesity. LH(4)(0) was the most informative hormonal parameter, but should not be interpreted in isolation. Test results should be integrated with clinical progression, auxological findings, skeletal maturation, biochemical data, and imaging when clinically indicated. CI - (c) 2026. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE). FAU - Hurmuzlu Kozler, Selen AU - Hurmuzlu Kozler S AUID- ORCID: 0000-0001-6533-2944 AD - Department of Pediatric Endocrinology, Kocaeli City Hospital, Kocaeli, Turkey. selenhurmuzlu@gmail.com. FAU - Kilci, Fatih AU - Kilci F AD - Department of Pediatric Endocrinology, Kocaeli City Hospital, Kocaeli, Turkey. FAU - Sarikaya, Emre AU - Sarikaya E AD - Department of Pediatric Endocrinology, Kocaeli City Hospital, Kocaeli, Turkey. FAU - Ozcan Murat, Nurhan AU - Ozcan Murat N AD - Department of Pediatric Endocrinology, Kocaeli City Hospital, Kocaeli, Turkey. LA - eng PT - Journal Article DEP - 20260821 PL - Italy TA - J Endocrinol Invest JT - Journal of endocrinological investigation JID - 7806594 SB - IM OTO - NOTNLM OT - Body mass index OT - Central precocious puberty OT - Diagnostic performance OT - GnRH stimulation test OT - Luteinizing hormone OT - Pelvic ultrasonography COIS- Declarations. Conflict of interest: The authors have no relevant financial or non-financial interests to disclose. Ethical approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Kocaeli City Hospital (No:2026/27). Informed consent: was waived due to the use of anonymized retrospective data. EDAT- 2026/08/21 17:37 MHDA- 2026/08/21 17:37 CRDT- 2026/08/21 11:18 PHST- 2026/06/13 00:00 [received] PHST- 2026/08/09 00:00 [accepted] PHST- 2026/08/21 17:37 [medline] PHST- 2026/08/21 17:37 [pubmed] PHST- 2026/08/21 11:18 [entrez] AID - 10.1007/s40618-026-03027-7 [pii] AID - 10.1007/s40618-026-03027-7 [doi] PST - aheadofprint SO - J Endocrinol Invest. 2026 Aug 21. doi: 10.1007/s40618-026-03027-7. PMID- 42626294 OWN - NLM STAT- MEDLINE DCOM- 20260821 LR - 20260926 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Hunger, satiety, and eating behavior after craniopharyngioma - narrative review on current management and future therapeutic perspectives. PG - 1895026 LID - 10.3389/fendo.2026.1895026 [doi] LID - 1895026 AB - Craniopharyngiomas are low-grade, intracranial tumors frequently associated with dysfunction of the hypothalamic-pituitary axes and the development of obesity. This narrative review aimed to evaluate the potential contribution of eating behaviors, while also identifying perspectives for future therapeutic intervention. Searches were performed across five bibliographic databases. All peer-reviewed published studies involving childhood-onset or adult-onset craniopharyngioma populations were considered eligible when they examined eating behavior in relation to pharmacological or surgical interventions, neuroimaging, endocrine responses, energy expenditure, sleep, and/or neuropsychological outcomes. The available evidence regarding eating behavior in individuals with craniopharyngioma was limited, with only 10 of the 82 included studies employing validated measures of eating behavior. Eating behavior was assessed as a primary outcome in seven studies, as a secondary outcome in twelve studies, and discussed without formal measurement in thirty-one studies. Only one randomized controlled trial with the melanocortin-4 receptor (MC4R) agonist setmelanotide was identified that successfully targeted eating behavior (hyperphagia) modification and achieved significant weight loss as an intervention for craniopharyngioma-related obesity. Greater insight into eating behavior in this population, supported by long-term studies using validated assessment tools, is required to clarify the mechanisms underlying craniopharyngioma-associated obesity and confirm effectiveness and tolerability of medical treatment with MC4R-agonists. CI - Copyright (c) 2026 Muller. FAU - Muller, Hermann L AU - Muller HL AD - Department of Pediatrics and Pediatric Hematology/Oncology, University Children's Hospital, Carl von Ossietzky Universitat, Klinikum Oldenburg AoR, Oldenburg, Germany. LA - eng PT - Journal Article PT - Review DEP - 20260806 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - *Craniopharyngioma/therapy/complications/physiopathology MH - *Pituitary Neoplasms/therapy/complications/physiopathology MH - *Feeding Behavior/physiology MH - *Hunger/physiology MH - *Satiation/physiology MH - Obesity/etiology PMC - PMC13491036 OTO - NOTNLM OT - craniopharyngioma OT - eating behavior OT - hunger OT - hypothalamus OT - obesity OT - quality of life OT - satiety OT - setmelanotide COIS- HM has received reimbursement of participation fees for scientific meetings and continuing medical education events, and reimbursement of travel expenses and lecture honoraria from Rhythm Pharmaceuticals. HM is specialty chief editor for the journal Frontiers in Endocrinology - Pituitary Endocrinology, guest associate editor for Frontiers Obesity and Frontiers Pediatric Endocrinology, and editorial board member of biomedicines mdpi. The author HM declared that he was an editorial board member of Frontiers at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/08/21 11:39 MHDA- 2026/08/21 11:40 PMCR- 2026/08/06 CRDT- 2026/08/21 06:02 PHST- 2026/05/29 00:00 [received] PHST- 2026/07/13 00:00 [revised] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/08/21 11:40 [medline] PHST- 2026/08/21 11:39 [pubmed] PHST- 2026/08/21 06:02 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 10.3389/fendo.2026.1895026 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Aug 6;17:1895026. doi: 10.3389/fendo.2026.1895026. eCollection 2026. PMID- 42625773 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260821 LR - 20260822 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 13 DP - 2026 TI - A descriptive cross-sectional study on the dry eye disease in children in Xiamen, China. PG - 1897928 LID - 10.3389/fmed.2026.1897928 [doi] LID - 1897928 AB - OBJECTIVE: To evaluate the clinical characteristics, risk factors, and applicability of three commonly used dry eye disease (DED) questionnaires (OSDI, CDEQ, and COCI) in children and adolescents in Xiamen, China, aiming to provide preliminary descriptive data in DED pediatric population. METHODS: This single-center cross-sectional study included 105 pediatric patients with DED. Demographic data, clinical findings, risk factors, and questionnaire scores were collected. Univariate analysis was used to identify associated factors. Internal consistency was assessed using Cronbach's alpha, inter-questionnaire correlations using Spearman analysis, and discriminative validity using Kruskal-Wallis and Mann-Whitney U tests. RESULTS: Among 105 participants (mean age 7.86 +/- 3.13 years; 64.76% male), the majority were elementary school-aged (54.29%). All patients exhibited meibomian gland dysfunction, and 92.38% had mixed-type DED. Age (p = 0.012), BMI (p = 0.067), outdoor activity (p = 0.029), and sleep duration (p = 0.055) were associated with DED subtype or severity. The response rates of the CDEQ and COCI were 100%. All questionnaires showed acceptable internal consistency (Cronbach's alpha = 0.642-0.919) and moderate correlations. However, none demonstrated significant discriminative ability for DED severity (p > 0.05). CONCLUSION: Given the cross-sectional design, no causal inference can be drawn from these findings. Within this descriptive framework, mixed-type DED with predominant MGD emerged as the main subtype in children in Xiamen. Obesity, limited outdoor activity, and short sleep duration were identified as potential correlates. The CDEQ and COCI showed acceptable feasibility and reliability, while the OSDI demonstrated limited applicability. None of the three questionnaires effectively distinguished severity, underscoring the need for pediatric-specific tools. CI - Copyright (c) 2026 Fang, Sun, Xiong, Yin, Yang and Bu. FAU - Fang, Weifang AU - Fang W AD - Department of Ophthalmology, Xiamen Children's Hospital (Children's Hospital of Fudan University at Xiamen), Xiamen Key Laboratory of Pediatric General Surgery Diseases, Xiamen, China. FAU - Sun, Le AU - Sun L AD - Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, China. FAU - Xiong, Weiwei AU - Xiong W AD - Department of Ophthalmology, Xiamen Children's Hospital (Children's Hospital of Fudan University at Xiamen), Xiamen Key Laboratory of Pediatric General Surgery Diseases, Xiamen, China. FAU - Yin, Xue AU - Yin X AD - Department of Ophthalmology, Xiamen Children's Hospital (Children's Hospital of Fudan University at Xiamen), Xiamen Key Laboratory of Pediatric General Surgery Diseases, Xiamen, China. FAU - Yang, Hui AU - Yang H AD - Department of Ophthalmology, Xiamen Children's Hospital (Children's Hospital of Fudan University at Xiamen), Xiamen Key Laboratory of Pediatric General Surgery Diseases, Xiamen, China. FAU - Bu, Jinghua AU - Bu J AD - Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, China. LA - eng PT - Journal Article DEP - 20260806 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC13490148 OTO - NOTNLM OT - CDEQ OT - COCI OT - OSDI OT - dry eye disease OT - pediatric dry eye disease OT - questionnaire COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/21 11:39 MHDA- 2026/08/21 11:40 PMCR- 2026/08/06 CRDT- 2026/08/21 05:21 PHST- 2026/06/02 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/08/21 11:40 [medline] PHST- 2026/08/21 11:39 [pubmed] PHST- 2026/08/21 05:21 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 10.3389/fmed.2026.1897928 [doi] PST - epublish SO - Front Med (Lausanne). 2026 Aug 6;13:1897928. doi: 10.3389/fmed.2026.1897928. eCollection 2026. PMID- 42625712 OWN - NLM STAT- MEDLINE DCOM- 20260821 LR - 20260822 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - External genital features and normative values for anogenital distances and penile length at birth in a healthy Italian population: data from the LIFE-MILCH project. PG - 1838976 LID - 10.3389/fendo.2026.1838976 [doi] LID - 1838976 AB - INTRODUCTION: Anogenital distance (AGD) and penile length (PL) are considered as surrogate biomarkers of fetal androgen action and are used to study the impact of prenatal exposure to endocrine disrupting chemicals. Data for newborn sex-specific references of both AGD and PL are currently scarce for the Italian population. This study aimed to provide normative data in a large group of Italian newborns and to assess any associations with anthropometric parameters. METHODS: Data were collected at birth in mother-infant dyads from April 2021 to September 2022. Four hundred and sixty-two/675 neonates at term of uncomplicated pregnancies were enrolled from three different Italian Hospitals. Newborns were divided in 5 subgroups according to weeks of gestational age(GA):1(37-37 + 6d w),2(38-38 + 6d w),3(39-39 + 6d w),4(40- 40 + 6d w),5(> 41w) and in 4 sub-groups according to birth weight (BW): A(2501-3000 g), B(3001-3500 g), C(3501-4000 g), D (>4001 g). Trained staff measured AGD and PL in newborns with an analogical caliper using the TIDES method. Anogenital distances (AGDs) considered were: ano-scrotal (AGD(AS)) and ano-penile (AGD(AP)) in males, ano-fourchette (AGD(AF)) and ano-clitoral (AGD(AC))in females. Correlations among AGDs and anthropometric measures were evaluated by Pearson correlation analysis. P<0.05 was significant. Data were expressed as mean+/- standard deviation. RESULTS: Overall, in males AGDs were longer than in females. Considering the 5 subgroups for GA, AGD(AP) was significantly longer than AGD(AC) in neonates born at and after 40 weeks(p<0.05) whereas AGD(AS) was significantly longer than AGD(AF) in neonates born at and after 39 weeks(p<0.05). AGD(AS) increased with increasing GA. Considering AGDs according to BW, AGD(AP) was significantly longer than AGD(AC) in newborns with a BW between 3001 and 4000 g(p<0.05), whereas AGD(AS) was significantly longer than AGD(AF) in newborns with a BW between 2501 g and 4000 g(p<0.05). Mean PL of male newborns (N = 208) was 24.4 +/- 6.83 mm and increased with GA. In the correlation analysis a positive significant correlation was found between AGD(AS) and PL (r=0.576, p<0.001). CONCLUSION: This study provided measurements and reference values for AGD and PL, based also on GA and BW, in a large group of newborns, supplying a valid well-reproducible instrument for clinical practice and the basis for further studies. CI - Copyright (c) 2026 Righi, Pelosi, Alberghi, Fontana, Davolio, Rotteglia, Sartori, Brambilla, Petrolini, Perrone, Shulhai, Dessi, Petza, Pintus, De Fanti, Gargano, Papini, Fanos, Palanza and Street. FAU - Righi, Beatrice AU - Righi B AD - Unit of Paediatrics, Department of Mother and Child, Azienda Unita Sanitaria Locale (USL)-IRCCS di Reggio Emilia, Reggio Emilia, Italy. FAU - Pelosi, Annalisa AU - Pelosi A AD - Department of Medicine and Surgery, University of Parma, Parma, Italy. FAU - Alberghi, Francesca AU - Alberghi F AD - Unit of Paediatrics, Department of Mother and Child, Azienda Unita Sanitaria Locale (USL)-IRCCS di Reggio Emilia, Reggio Emilia, Italy. FAU - Fontana, Marta AU - Fontana M AD - Unit of Paediatrics, Department of Mother and Child, Azienda Unita Sanitaria Locale (USL)-IRCCS di Reggio Emilia, Reggio Emilia, Italy. FAU - Davolio, Emanuela AU - Davolio E AD - Unit of Obstetrics and Gynecology, Azienda Unita Sanitaria Locale (USL)-IRCCS of Reggio Emilia, Reggio Emilia, Italy. FAU - Rotteglia, Cecilia AU - Rotteglia C AD - Unit of Obstetrics and Gynecology, Azienda Unita Sanitaria Locale (USL)-IRCCS of Reggio Emilia, Reggio Emilia, Italy. FAU - Sartori, Chiara AU - Sartori C AD - Unit of Paediatrics, Department of Mother and Child, Azienda Unita Sanitaria Locale (USL)-IRCCS di Reggio Emilia, Reggio Emilia, Italy. FAU - Brambilla, M Maddalena AU - Brambilla MM AD - Department of Medicine and Surgery, University of Parma, Parma, Italy. AD - Neonatology Unit, Department of Medicine and Surgery, University of Parma, Pietro Barilla Children's Hospital, Parma, Italy. FAU - Petrolini, Chiara AU - Petrolini C AD - Neonatology Unit, Department of Medicine and Surgery, University of Parma, Pietro Barilla Children's Hospital, Parma, Italy. FAU - Perrone, Serafina AU - Perrone S AD - Department of Medicine and Surgery, University of Parma, Parma, Italy. AD - Neonatology Unit, Department of Medicine and Surgery, University of Parma, Pietro Barilla Children's Hospital, Parma, Italy. FAU - Shulhai, Anna-Mariia AU - Shulhai AM AD - Department of Medicine and Surgery, University of Parma, Parma, Italy. FAU - Dessi, Angelica AU - Dessi A AD - Neonatal Intensive Care Unit, Department of Surgical Sciences, University of Cagliari, Azienda Ospedaliero Universitaria (AOU) Cagliari, Cagliari, Italy. FAU - Petza, Silvia AU - Petza S AD - Neonatal Intensive Care Unit, Department of Surgical Sciences, University of Cagliari, Azienda Ospedaliero Universitaria (AOU) Cagliari, Cagliari, Italy. FAU - Pintus, Roberta AU - Pintus R AD - Neonatal Intensive Care Unit, Department of Surgical Sciences, University of Cagliari, Azienda Ospedaliero Universitaria (AOU) Cagliari, Cagliari, Italy. FAU - De Fanti, Alessandro AU - De Fanti A AD - Unit of Paediatrics, Department of Mother and Child, Azienda Unita Sanitaria Locale (USL)-IRCCS di Reggio Emilia, Reggio Emilia, Italy. FAU - Gargano, Giancarlo AU - Gargano G AD - Department of Mother and Child, Neonatal Intensive Care Unit, Azienda Unita Sanitaria Locale (USL)-IRCCS di Reggio Emilia, Reggio Emilia, Italy. FAU - Papini, Anna Maria AU - Papini AM AD - Department of Chemistry "Ugo Schiff", University of Florence, Sesto Fiorentino, Italy. FAU - Fanos, Vassilios AU - Fanos V AD - Neonatal Intensive Care Unit, Department of Surgical Sciences, University of Cagliari, Azienda Ospedaliero Universitaria (AOU) Cagliari, Cagliari, Italy. AD - Department of Medicine and Surgery, University of Cagliari, Cagliari, Italy. FAU - Palanza, Paola AU - Palanza P AD - Department of Medicine and Surgery, University of Parma, Parma, Italy. FAU - Street, Maria Elisabeth AU - Street ME AD - Unit of Paediatrics, Department of Mother and Child, Azienda Unita Sanitaria Locale (USL)-IRCCS di Reggio Emilia, Reggio Emilia, Italy. AD - Department of Medicine and Surgery, University of Parma, Parma, Italy. AD - Unit of Paediatrics, University Hospital of Parma, Parma, Italy. LA - eng PT - Journal Article DEP - 20260806 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - Male MH - Infant, Newborn MH - Female MH - *Penis/anatomy & histology MH - Italy/epidemiology MH - *Anal Canal/anatomy & histology MH - Reference Values MH - Birth Weight MH - Gestational Age MH - Pregnancy MH - Adult PMC - PMC13489917 OTO - NOTNLM OT - anogenital distance OT - newborn OT - normative values OT - penile length OT - references COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors PP, AMP, MES declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/08/21 11:39 MHDA- 2026/08/21 11:40 PMCR- 2026/08/06 CRDT- 2026/08/21 05:12 PHST- 2026/03/25 00:00 [received] PHST- 2026/06/12 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/08/21 11:40 [medline] PHST- 2026/08/21 11:39 [pubmed] PHST- 2026/08/21 05:12 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 10.3389/fendo.2026.1838976 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Aug 6;17:1838976. doi: 10.3389/fendo.2026.1838976. eCollection 2026. PMID- 42624607 OWN - NLM STAT- MEDLINE DCOM- 20260820 LR - 20260827 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 8 DP - 2026 Aug 19 TI - Reassessing mid-upper arm circumference thresholds for predicting nutritional status and pregnancy outcomes among pregnant adolescents in Bundibugyo District, Uganda: protocol for a health facility-based prospective cohort study. PG - e121400 LID - 10.1136/bmjopen-2026-121400 [doi] LID - e121400 AB - INTRODUCTION: In 2023, Sub-Saharan Africa recorded the world's highest teenage pregnancy rate of 4.4 per 1000 women compared with the global average of 1.5 per 1000, highlighting the need for accurate nutritional assessment during pregnancy. Current mid-upper arm circumference (MUAC) thresholds differ between non-pregnant adolescents (18.5 cm) and pregnant adolescents (23 cm) as per the Uganda Integrated Management of Acute Malnutrition guidelines. This classification can lead to inadequate treatment and mislabelling of adolescents as non-responders, despite nutritional improvements. This study will reassess MUAC thresholds for predicting nutritional status and pregnancy outcomes among pregnant adolescents in Bundibugyo District, Uganda. METHODS AND ANALYSIS: This health facility-based prospective cohort study will target 241 pregnant women comprising 121 pregnant adolescents (10-19 years) and 120 adults (20-49 years) in their first trimester (/= 5.6 mmol/L were randomly selected from 210 participants, alongside 60 matched healthy controls (FPG < 5.6 mmol/L). Semiquantitative lipidomics was performed, and lipid ratios were calculated from identified characteristic lipids. Univariate and multiple regression analyses were conducted. RESULTS: After adjusting for age, sex, body mass index (BMI), early-life risk factors, and metabolic disorder factors, six lipid species remained independently associated with FPG variations (Bonferroni-adjusted p < 0.05). Lipid ratios derived from these six lipids differed significantly between groups; the decreased levels of phosphatidylethanolamine/diacyl-phosphatidylcholine was significantly correlated with elevated FPG, whereas elevated levels of ether-phosphoatidylcholine/diacyl-phosphoatidylcholine ratios was significantly associated with elevated FPG. Three phosphatidylcholine species showed good diagnostic performance (AUC = 0.811, 95% CI: 0.733-0.881). Their composite signature outperformed both the baseline model (age, sex; AUC: 0.882 vs. 0.584, DeLong's p < 0.001), and the extended risk factor model (age, sex, BMI, and early-life riskr factors, AUC: 0.882 vs. 0.635, DeLong's p < 0.001). The robustness of the three PCs was further supported by sensitivity analyses, which demonstrated consistent performance using Firth penalized regression (AUC = 0.883) and an alternative FPG cutoff at the 75th percentile (AUC = 0.834). CONCLUSIONS: In this cross-sectional targeted lipidomics study, a three PC lipid panel was independently associated with subclinical hyperglycemia in preschool-aged children and showed robust diagnostic performance. Two lipid ratios were also associated with FPG. These findings identify a potential lipid panel for early risk detection in this understudied population, pending validation in larger cohorts. CI - Copyright (c) 2026 Zhang, Wang, Lv, Huang, Guo, Jiang, Zhang, Liu and Chen. FAU - Zhang, Haifeng AU - Zhang H AD - Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Wang, Jing AU - Wang J AD - Tianjin Women and Children's Health Center, Tianjin, China. FAU - Lv, Yueguang AU - Lv Y AD - Key Laboratory of Consumer Product Quality Safety Inspection and Risk Assessment, State Administration for Market Regulation, Beijing, China. FAU - Huang, Yiying AU - Huang Y AD - Department of Epidemiology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Guo, Yuanyuan AU - Guo Y AD - Tianjin Women and Children's Health Center, Tianjin, China. FAU - Jiang, Chang AU - Jiang C AD - Tianjin Women and Children's Health Center, Tianjin, China. FAU - Zhang, Ting AU - Zhang T AD - Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Liu, Gongshu AU - Liu G AD - Tianjin Women and Children's Health Center, Tianjin, China. FAU - Chen, Fangfang AU - Chen F AD - Department of Epidemiology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. LA - eng PT - Journal Article DEP - 20260805 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Phosphatidylcholines) RN - 0 (Blood Glucose) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - *Hyperglycemia/diagnosis/blood MH - Male MH - Pilot Projects MH - Cross-Sectional Studies MH - Child, Preschool MH - *Phosphatidylcholines/blood MH - Blood Glucose/analysis/metabolism MH - *Biomarkers/blood MH - Lipidomics PMC - PMC13485523 OTO - NOTNLM OT - diagnostic signature OT - glycerophopholipids OT - lipid ratio OT - lipidomics OT - pediatric hyperglycemia COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/20 11:41 MHDA- 2026/08/20 11:42 PMCR- 2026/08/05 CRDT- 2026/08/20 07:32 PHST- 2026/05/11 00:00 [received] PHST- 2026/07/13 00:00 [revised] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/08/20 11:42 [medline] PHST- 2026/08/20 11:41 [pubmed] PHST- 2026/08/20 07:32 [entrez] PHST- 2026/08/05 00:00 [pmc-release] AID - 10.3389/fendo.2026.1878086 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Aug 5;17:1878086. doi: 10.3389/fendo.2026.1878086. eCollection 2026. PMID- 42617192 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20260822 IS - 1598-6357 (Electronic) IS - 1011-8934 (Print) IS - 1011-8934 (Linking) VI - 41 IP - 32 DP - 2026 Aug 17 TI - Twin Birth Weight Chart Comparisons in Korea. PG - e215 LID - 10.3346/jkms.2026.41.e215 [doi] LID - e215 AB - BACKGROUND: Birth weight deviations from gestational age-specific standards affect neonatal outcomes. While singleton references are established, their applicability to twins is debated. With the increasing incidence of twin and preterm births, twin-specific growth standards remain limited in Korea. This study systematically analyzed twin growth trajectories, considering sex, mode of conception, and chorionicity, to establish accurate references. METHODS: This study analyzed data from the Korean Neonatal Network (2013-2020; 60 years). T-scores for RF parameters were derived from a young reference subgroup aged 18-45 years (n = 1001). Associations with sex, age, body mass index and physical activity were analysed. RESULTS: All NU parameters differed significantly by sex (all p < 0.001). Median RF-CSA was 4.60 cm(2) (IQR 3.83-5.58) in women and 6.77 cm(2) (5.55-7.91) in men; median RF-Y axis at rest was 1.56 cm (1.33-1.80) and 1.91 cm (1.65-2.17), and during contraction 1.97 cm (1.71-2.24) and 2.47 cm (2.15-2.78), respectively. Median total abdominal subcutaneous adipose tissue (T-SAT) was 1.77 cm (1.16-2.39) in women and 1.65 cm (1.13-2.22) in men. RF measurements correlated moderately-strongly with BIA-derived muscle mass (r = 0.45-0.65) and HGS (r = 0.49-0.58). T-SAT correlated with BIA fat mass and waist circumference (r = 0.45-0.65), whereas visceral adipose tissue showed weaker associations (r approximately 0.33). RF-CSA and RF-Y axis increased across physical-activity categories (p < 0.05). Absolute RF values did not differ by BMI; however, when indexed to body weight, participants with BMI > 25 kg/m(2) had lower RF-CSA and RF-Y values (all p < 0.001). RF parameters followed a normal distribution, whereas adipose tissue measures did not. In the young reference group (18-45 years), mean +/- SD RF-Y axis was 1.68 +/- 0.33 cm in women and 2.05 +/- 0.37 cm in men. When applying T-score criteria, the -2 standard deviation cut-off identified 1.4%-11.7% of adults aged >/=45 years as having low muscle mass. CONCLUSIONS: This study provides the first age- and sex-specific population-based reference values for nutritional ultrasound measurements in an apparently healthy adult Spanish population. These findings support the validity, clinical applicability, and standardisation of nutritional ultrasound for the assessment of muscle mass, with potential utility in the diagnosis of sarcopenia and malnutrition. CI - (c) 2026 The Author(s). Journal of Cachexia, Sarcopenia and Muscle published by Wiley Periodicals LLC. FAU - Moreno-Torres-Taboada, Carolina AU - Moreno-Torres-Taboada C AUID- ORCID: 0009-0002-2768-8151 AD - Department of Endocrinology and Nutrition, Regional University Hospital of Malaga, Malaga, Spain. AD - Department of Medicine and Dermatology, Faculty of Medicine, University of Malaga, Malaga, Spain. FAU - Romero-Marquez, Jose M AU - Romero-Marquez JM AD - Department of Endocrinology and Nutrition, Virgen de las Nieves University Hospital, Granada, Spain. AD - Foundation for Biosanitary Research of Eastern Andalusia - Alejandro Otero (FIBAO), Granada, Spain. AD - Faculty of Health Sciences. Department of Nutrition and Sports Sciences, International University of La Rioja, Logrono, Spain. FAU - Garcia-Olivares, Maria AU - Garcia-Olivares M AD - Department of Endocrinology and Nutrition, Regional University Hospital of Malaga, Malaga, Spain. AD - Department of Medicine and Dermatology, Faculty of Medicine, University of Malaga, Malaga, Spain. AD - IBIMA BIONAND Platform, Biomedical Research Institute of Malaga, Malaga, Spain. AD - Department of Endocrinology and Nutrition, QuironSalud Malaga Hospital, Malaga, Spain. FAU - Novo-Rodriguez, Maria AU - Novo-Rodriguez M AD - Department of Endocrinology and Nutrition, Virgen de las Nieves University Hospital, Granada, Spain. AD - Foundation for Biosanitary Research of Eastern Andalusia - Alejandro Otero (FIBAO), Granada, Spain. FAU - Fernandez-Jimenez, Rocio AU - Fernandez-Jimenez R AD - Department of Medicine and Dermatology, Faculty of Medicine, University of Malaga, Malaga, Spain. AD - IBIMA BIONAND Platform, Biomedical Research Institute of Malaga, Malaga, Spain. AD - Department of Endocrinology and Nutrition, QuironSalud Malaga Hospital, Malaga, Spain. AD - Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Malaga, Spain. FAU - Vegas-Aguilar, Isabel AU - Vegas-Aguilar I AD - IBIMA BIONAND Platform, Biomedical Research Institute of Malaga, Malaga, Spain. AD - Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Malaga, Spain. FAU - Garcia-Luna, Pedro Pablo AU - Garcia-Luna PP AD - Nutrition Unit, Endocrinology and Nutrition Department, Virgen del Rocio University Hospital, Sevilla, Spain. FAU - Garcia-Rey, Silvia AU - Garcia-Rey S AD - Nutrition Unit, Endocrinology and Nutrition Department, Virgen del Rocio University Hospital, Sevilla, Spain. FAU - Garcia-Almeida, Jose Manuel AU - Garcia-Almeida JM AD - Department of Medicine and Dermatology, Faculty of Medicine, University of Malaga, Malaga, Spain. AD - IBIMA BIONAND Platform, Biomedical Research Institute of Malaga, Malaga, Spain. AD - Department of Endocrinology and Nutrition, QuironSalud Malaga Hospital, Malaga, Spain. AD - Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Malaga, Spain. AD - Network Biomedical Research Center Physiopathology of Obesity and Nutrition (CiberOBN), Carlos III Health Institute, Madrid, Spain. FAU - Olveira, Gabriel AU - Olveira G AD - Department of Endocrinology and Nutrition, Regional University Hospital of Malaga, Malaga, Spain. AD - Department of Medicine and Dermatology, Faculty of Medicine, University of Malaga, Malaga, Spain. AD - IBIMA BIONAND Platform, Biomedical Research Institute of Malaga, Malaga, Spain. AD - Biomedical Research Networking Center in Diabetes and Associated Metabolic Disorders (CIBERDEM), Instituto de Salud Carlos III, Malaga, Spain. CN - VALORES Group LA - eng GR - C24051/Fresenius Kabi/ PT - Journal Article PT - Multicenter Study PL - Germany TA - J Cachexia Sarcopenia Muscle JT - Journal of cachexia, sarcopenia and muscle JID - 101552883 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Middle Aged MH - Reference Values MH - Aged MH - Ultrasonography/methods MH - Adolescent MH - Aged, 80 and over MH - Young Adult MH - Cross-Sectional Studies MH - Body Composition MH - *Muscle, Skeletal/diagnostic imaging/physiology MH - Adipose Tissue/diagnostic imaging PMC - PMC13487697 OTO - NOTNLM OT - body composition OT - malnutrition OT - muscle ultrasound OT - nutritional ultrasound OT - reference values OT - sarcopenia COIS- The authors declare no conflicts of interest. FIR - The Valores Group, For IR - The Valores Group F FIR - Lopez-de-la-Torre-Casares, Martin IR - Lopez-de-la-Torre-Casares M IRAD- Department of Endocrinology and Nutrition, Virgen de las Nieves University Hospital, Granada, Spain. FIR - Munoz-Garach, Araceli IR - Munoz-Garach A IRAD- Department of Endocrinology and Nutrition, Virgen de las Nieves University Hospital, Granada, Spain. FIR - Novo-Rodriguez, Cristina IR - Novo-Rodriguez C IRAD- Department of Endocrinology and Nutrition, Virgen de las Nieves University Hospital, Granada, Spain. FIR - Guardia-Baena, Juan Manuel IR - Guardia-Baena JM IRAD- Department of Endocrinology and Nutrition, Virgen de las Nieves University Hospital, Granada, Spain. FIR - Padial-Barranco, Marina IR - Padial-Barranco M IRAD- Department of Endocrinology and Nutrition, Regional University Hospital of Malaga, Malaga, Spain. FIR - Porras-Perez, Nuria IR - Porras-Perez N IRAD- Department of Endocrinology and Nutrition, Regional University Hospital of Malaga, Malaga, Spain. FIR - Rojo-Martinez, Gemma IR - Rojo-Martinez G IRAD- Department of Endocrinology and Nutrition, Regional University Hospital of Malaga, Malaga, Spain. FIR - Del Carmen Roque-Cuellar, Maria IR - Del Carmen Roque-Cuellar M IRAD- Nutrition Unit, Endocrinology and Nutrition Department, Virgen del Rocio University Hospital, Sevilla, Spain. FIR - Jimenez-Sanchez, Andres IR - Jimenez-Sanchez A IRAD- Nutrition Unit, Endocrinology and Nutrition Department, Virgen del Rocio University Hospital, Sevilla, Spain. FIR - Martinez-Ortega, Antonio Jesus IR - Martinez-Ortega AJ IRAD- Nutrition Unit, Endocrinology and Nutrition Department, Virgen del Rocio University Hospital, Sevilla, Spain. EDAT- 2026/08/19 14:49 MHDA- 2026/08/19 14:50 PMCR- 2026/08/19 CRDT- 2026/08/19 06:13 PHST- 2026/06/18 00:00 [revised] PHST- 2026/02/18 00:00 [received] PHST- 2026/06/25 00:00 [accepted] PHST- 2026/08/19 14:50 [medline] PHST- 2026/08/19 14:49 [pubmed] PHST- 2026/08/19 06:13 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - JCSM70344 [pii] AID - 10.1002/jcsm.70344 [doi] PST - ppublish SO - J Cachexia Sarcopenia Muscle. 2026 Aug;17(4):e70344. doi: 10.1002/jcsm.70344. PMID- 42614353 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260819 LR - 20260820 IS - 2673-3153 (Electronic) IS - 2673-3153 (Print) IS - 2673-3153 (Linking) VI - 8 DP - 2026 TI - The value of anti-Mullerian hormone for diagnosing polycystic ovary syndrome in adolescents: a case-control study based on an epidemiological survey. PG - 1907699 LID - 10.3389/frph.2026.1907699 [doi] LID - 1907699 AB - BACKGROUND: Updated 2023 international evidence-based guidelines do not recommend anti-Mullerian hormone (AMH) for diagnosing adolescent polycystic ovary syndrome (PCOS, also newly termed polyendocrine metabolic ovarian syndrome [PMOS]) due to limited specificity. Physiological multifollicular ovaries are prevalent in teenagers, and existing studies show massive heterogeneity in participant age, BMI, AMH detection platforms and cut-off thresholds without unified adolescent-specific standards. This study aimed to analyze serum AMH correlations with core adolescent PCOS phenotypes and evaluate the auxiliary diagnostic performance of AMH for adolescent PCOS. METHODS: Based on a cross-sectional school-based epidemiological survey among adolescent girls aged 14-18 years, we enrolled 211 healthy girls, 158 girls with oligo-/amenorrhea, 38 girls with isolated clinical hirsutism, 51 girls with isolated biochemical hyperandrogenemia, and 39 adolescent PCOS patients for case-control analysis. Pearson's correlation coefficients were calculated to determine the correlations between AMH and various parameters. Receiver Operating Characteristic (ROC) curve analysis was performed to examine the diagnostic performance of AMH. RESULTS: Serum AMH concentrations were significantly higher in girls with oligo-/amenorrhea and isolated biochemical hyperandrogenemia relative to healthy controls (P < 0.05), while isolated hirsutism presented comparable AMH levels with controls (P > 0.05). Adolescent PCOS patients had the highest AMH levels among all subgroups (P < 0.05). AMH was positively correlated with all circulating androgen markers (T, FAI, A2, fT, DHEAS) but showed no correlation with age, menarcheal age, gynecological age, BMI, WHR or SHBG. Within the PCOS cohort, only serum testosterone maintained an independent positive correlation with AMH (r = 0.450, P = 0.004). ROC analysis showed an AUC of AMH for adolescent PCOS of 0.717 (95%CI: 0.625-0.809, P < 0.001). Bootstrap-validated optimal AMH cut-off value was 4.0 ng/mL, with sensitivity 51.3% (95CI: 35.4%-67.2%) and specificity 86.1% (95CI: 81.2%-90.0%). post-hoc power analysis demonstrated moderate statistical power of 0.74 for this ROC model due to limited PCOS sample size (n = 39). CONCLUSIONS: Serum AMH is closely correlated with two core diagnostic manifestations of adolescent PCOS: ovulatory dysfunction and biochemical hyperandrogenemia. Nevertheless, the low sensitivity of the 4.0 ng/mL threshold leads to nearly half missed PCOS cases if used alone for screening. Combined with inherent incorporation bias, absence of ovarian ultrasound data and consistent 2023 guideline recommendations, AMH can only serve as an adjunctive auxiliary biomarker rather than an independent diagnostic or screening tool for adolescent PCOS. Multicenter studies with standardized ovarian ultrasonography and external validation cohorts are required to establish generalizable age-specific AMH cut-offs for adolescents. CI - (c) 2026 Hong, Li, Yang, Zhou and Dong. FAU - Hong, Yu AU - Hong Y AD - Department of Obstetrics and Gynecology, Memorial Hospital of Sun Yat-Sen University, Guangzhou, China. AD - Department of Obstetrics and Gynecology, Kiangwu Hospital, Macao SAR, China. FAU - Li, Enping AU - Li E AD - Department of Obstetrics and Gynecology, Kiangwu Hospital, Macao SAR, China. FAU - Yang, Dongzi AU - Yang D AD - Department of Obstetrics and Gynecology, Memorial Hospital of Sun Yat-Sen University, Guangzhou, China. FAU - Zhou, Zehong AU - Zhou Z AD - Department of Obstetrics and Gynecology, Memorial Hospital of Sun Yat-Sen University, Guangzhou, China. FAU - Dong, Zhe AU - Dong Z AD - Department of Obstetrics and Gynecology, Memorial Hospital of Sun Yat-Sen University, Guangzhou, China. LA - eng PT - Journal Article DEP - 20260804 PL - Switzerland TA - Front Reprod Health JT - Frontiers in reproductive health JID - 9918230899006676 PMC - PMC13481504 OTO - NOTNLM OT - adolescence OT - anti-Mullerian hormone OT - auxiliary diagnostic biomarker OT - polycystic ovary syndrome OT - polyendocrine metabolic ovarian syndrome COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/19 14:49 MHDA- 2026/08/19 14:50 PMCR- 2026/08/04 CRDT- 2026/08/19 05:07 PHST- 2026/06/15 00:00 [received] PHST- 2026/07/09 00:00 [revised] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/08/19 14:50 [medline] PHST- 2026/08/19 14:49 [pubmed] PHST- 2026/08/19 05:07 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - 10.3389/frph.2026.1907699 [doi] PST - epublish SO - Front Reprod Health. 2026 Aug 4;8:1907699. doi: 10.3389/frph.2026.1907699. eCollection 2026. PMID- 42614308 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260819 LR - 20260820 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Gut microbiota of sprint athletes: signature microbes and dietary links. PG - 1855417 LID - 10.3389/fnut.2026.1855417 [doi] LID - 1855417 AB - BACKGROUND: The gut microbiota has emerged as an important biological factor associated with host physiological status in athletes. However, relevant research remains limited for sprint athletes, whose physiological demands differ substantially from those of endurance athletes. OBJECTIVE: This study aimed to characterize the gut microbiota profile of college sprint athletes, compare it with non-athletic peers, identify potential sprint-associated bacterial taxa, and explore diet-microbiota associations to propose potential nutritional hypotheses for these signature taxa. METHODS: Fecal samples were collected from 20 college sprint athletes and 23 non-athletic college students for metagenomic sequencing. Dietary intake was assessed using a validated food frequency questionnaire. Alpha and beta diversity analyses were performed to evaluate microbial community diversity and structure. LEfSe was used to identify differentially abundant taxa. Functional annotation and enrichment were conducted using KEGG, GO, and other databases. Spearman's correlation was applied to examine diet-microbiota relationships. RESULTS: Alpha diversity indices (Shannon, Chao1, etc.) did not differ significantly between groups. In contrast, beta diversity analysis revealed significant structural separation. LEfSe identified Segatella copri (LDA = 4.986, p = 0.017) and Bifidobacterium adolescentis (LDA = 3.154, p = 0.003) as signature taxa in athletes, both with significantly higher abundance than in non-athletes. Functional analysis showed predicted enrichment of pathways related to energy metabolism (carbohydrate metabolism, ATP binding) and amino acid metabolism in athletes. Correlation analysis indicated that S. copri abundance was nominally positively associated with dairy intake (r = 0.31, p = 0.045), while B. adolescentis was nominally associated with whole grains, soy milk/soy powder, and dairy products. CONCLUSION: College sprint athletes possess a distinct gut microbiota structure compared with non-athletes. S. copri and B. adolescentis represent distinct microbial signatures associated with sprint athletes, accompanied by corresponding predicted functional pathway enrichment. Specific dietary patterns, including the intake of whole grains, soy milk/soy powder, and dairy products, exhibit exploratory nominal associations with the signature gut microbiota composition of sprinters. CI - Copyright (c) 2026 Su, Lan, Chen and Wang. FAU - Su, Chuanjian AU - Su C AD - Clinical Medical College of Anhui Medical University, Anhui Medical University, Hefei, Anhui, China. FAU - Lan, Jinfeng AU - Lan J AD - Army Arms University of PLA, Hefei, Anhui, China. FAU - Chen, Huimin AU - Chen H AD - The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, China. FAU - Wang, Daoming AU - Wang D AD - School of Physical Education and Health, Anhui Medical University, Hefei, Anhui, China. LA - eng PT - Journal Article DEP - 20260804 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13481514 OTO - NOTNLM OT - college students OT - diet-microbiota interaction OT - gut microbiota OT - metagenomic sequencing OT - sprint athletes OT - sprint-associated bacteria COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/19 14:49 MHDA- 2026/08/19 14:50 PMCR- 2026/08/04 CRDT- 2026/08/19 05:00 PHST- 2026/04/14 00:00 [received] PHST- 2026/07/03 00:00 [revised] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/08/19 14:50 [medline] PHST- 2026/08/19 14:49 [pubmed] PHST- 2026/08/19 05:00 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - 10.3389/fnut.2026.1855417 [doi] PST - epublish SO - Front Nutr. 2026 Aug 4;13:1855417. doi: 10.3389/fnut.2026.1855417. eCollection 2026. PMID- 42613030 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260926 IS - 1464-3685 (Electronic) IS - 0300-5771 (Print) IS - 0300-5771 (Linking) VI - 55 IP - 5 DP - 2026 Aug 18 TI - Elucidating the proteomic pathways linking childhood body mass index with type 2 diabetes: a Mendelian randomization and recall-by-genotype study. LID - 10.1093/ije/dyag165 [doi] LID - dyag165 AB - BACKGROUND: Increased childhood adiposity contributes to higher type 2 diabetes (T2D) risk, but the underlying mechanisms remain unclear. Furthermore, whether these mechanistic pathways are shared across ethnic groups has not been explored. METHODS: We conducted a two-step Mendelian randomization (MR) using European-based summary statistics from genome-wide association studies of childhood body mass index (BMI) (n = 61 111), adulthood proteomics (n = 35 559), and later life T2D (cases: 242 283; controls: 1 569 734). We also conducted a recall-by-genotype (RbG) study in a Chinese birth cohort (n = 250) to assess whether childhood BMI was associated with the identified proteomic signals in an East Asian population. Analyses included multi-instrument MR methods (inverse variance weighted and MR-Egger) and, for single-instrument proteins, cis-MR using the Wald ratio, with colocalization validation. Multiple testing was adjusted using false discovery rate (FDR). RESULTS: Higher genetically predicted childhood BMI was associated with 1299 proteins (FDR-adjusted P < .05), of which 36 proteins were associated with higher T2D risk. Six proteins were supported by colocalization (PPH4 > 80%). Genetically predicted higher childhood BMI was positively associated with GCKR, RBP1, ENTPD6, and GST A1-1, and inversely associated with PRSS27 and SHBG. The proportion of the BMI-T2D effect mediated by these proteins ranged from 1.87% to 12.92%. However, only SHBG was replicated in Asians in the RbG study. CONCLUSIONS: Our study identified putative actionable proteins that could reduce the elevated T2D risk attributable to childhood adiposity in Europeans, but their relevance in Asian populations requires further investigation. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the International Epidemiological Association. FAU - Chen, Siyu AU - Chen S AD - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. FAU - Liang, Yiwen AU - Liang Y AD - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. FAU - Luo, Shan AU - Luo S AUID- ORCID: 0000-0003-3368-9935 AD - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. AD - Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. FAU - Zheng, Jie AU - Zheng J AUID- ORCID: 0000-0002-4265-6695 AD - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Yoshiji, Satoshi AU - Yoshiji S AD - Department of Human Genetics, McGill University, Montreal, QC, Canada. FAU - Power, Grace M AU - Power GM AUID- ORCID: 0000-0002-5702-7728 AD - MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom. AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom. AD - Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia. FAU - Xu, Zikun AU - Xu Z AD - Department of Electrical and Electronic Engineering, Imperial College London, London, United Kingdom. FAU - Burgess, Stephen AU - Burgess S AUID- ORCID: 0000-0001-5365-8760 AD - MRC Biostatistics Unit, Cambridge Institute of Public Health, University of Cambridge, Cambridge, United Kingdom. FAU - Cowling, Benjamin John AU - Cowling BJ AUID- ORCID: 0000-0002-6297-7154 AD - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. FAU - Lam, Hugh Simon AU - Lam HS AD - Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China. FAU - Li, Albert Martin AU - Li AM AD - Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China. FAU - Leung, Gabriel Matthew AU - Leung GM AD - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. FAU - Schooling, Catherine Mary AU - Schooling CM AUID- ORCID: 0000-0001-9933-5887 AD - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. AD - Graduate School of Public Health and Health Policy, City University of New York, New York, NY, United States. FAU - Au Yeung, Shiu Lun AU - Au Yeung SL AUID- ORCID: 0000-0001-6136-1836 AD - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. LA - eng GR - 216106/Health Care and Promotion Fund, Health and Welfare Bureau, Government of the Hong Kong SAR/ GR - 03040771/Health and Health Services Research Fund/ GR - 05060671/Health and Health Services Research Fund/ GR - 07080751/Health and Health Services Research Fund/ GR - 07080841/Health and Health Services Research Fund/ PT - Journal Article PL - England TA - Int J Epidemiol JT - International journal of epidemiology JID - 7802871 RN - Chinese people SB - IM MH - Adult MH - Child MH - Female MH - Humans MH - Male MH - *Body Mass Index MH - *Diabetes Mellitus, Type 2/genetics/metabolism MH - Genome-Wide Association Study MH - Genotype MH - Mendelian Randomization Analysis MH - *Pediatric Obesity/genetics/metabolism MH - Polymorphism, Single Nucleotide MH - Proteomics MH - White People/genetics MH - East Asian People/genetics MH - Genetic Predisposition to Disease PMC - PMC13485351 OTO - NOTNLM OT - childhood obesity OT - proteomics OT - type 2 diabetes COIS- S.L.A.Y. received honoraria from Standard BioTools for scientific presentations on proteomic studies that was related to this study. However, Standard BioTools was not involved in the study design and data analysis of this study. S.B. and C.M.S. serve as editors of the International Journal of Epidemiology, but were not involved in the review, editorial assessment, or decision to publish this manuscript. Other authors declared no conflict of interest. EDAT- 2026/08/18 23:36 MHDA- 2026/08/18 23:37 PMCR- 2026/08/18 CRDT- 2026/08/18 20:03 PHST- 2025/11/02 00:00 [received] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/08/18 23:37 [medline] PHST- 2026/08/18 23:36 [pubmed] PHST- 2026/08/18 20:03 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - 8764056 [pii] AID - dyag165 [pii] AID - 10.1093/ije/dyag165 [doi] PST - ppublish SO - Int J Epidemiol. 2026 Aug 18;55(5):dyag165. doi: 10.1093/ije/dyag165. PMID- 42609271 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260818 LR - 20260819 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Nutritional and behavioral determinants of overweight and obesity among school-aged children in Shandong Province, China: evidence from a large-scale cross-sectional study. PG - 1853192 LID - 10.3389/fnut.2026.1853192 [doi] LID - 1853192 AB - BACKGROUND: Childhood overweight and obesity are pressing global health challenges with rising prevalence in China. Shandong Province, as a populous and economically developed region, provides a critical context for understanding regional patterns and determinants. METHODS: A cross-sectional survey was conducted among 83,436 children aged 9-12 years from 155 schools in 16 cities (September-November 2025). Anthropometric measurements and validated questionnaires were used to assess weight status, demographics, family environment, and lifestyle factors. Overweight/obesity was classified using International Obesity Task Force (IOTF) cut-offs. Logistic regression identified associated risk and protective factors. RESULTS: The prevalence of overweight/obesity was 19.0%. Rates were higher in boys than girls (19.9% vs. 18.2%, p < 0.001) and increased with age (11-year-olds 20.4% vs. 9-year-olds 18.0%, p < 0.001). Urban children had slightly higher prevalence than rural peers (19.6% vs. 18.7%, p = 0.002). Factors independently associated with overweight/obesity included parental overweight/obesity (OR = 1.18, 95% CI: 1.10-1.26), maternal gestational diabetes (OR = 1.53, 95% CI: 1.36-1.71), and high birth weight (OR = 1.16, 95% CI: 1.09-1.24). Lifestyle behaviors were strongly associated: <1 h/day physical activity increased risk, while >1.5 h/day was protective (OR = 0.83, 95% CI: 0.79-0.87); >8 h sleep reduced risk (OR = 0.66, 95% CI: 0.60-0.72); >3 h/day screen time (OR = 1.10, 95% CI: 1.02-1.20) and >3 h/day homework (OR = 1.49, 95% CI: 1.38-1.62) elevated risk; frequent fruit/vegetable intake was protective, whereas fast-food consumption >3 times/week increased risk (OR = 1.12, 95% CI: 1.05-1.20). CONCLUSION: Childhood overweight/obesity in Shandong Province is influenced by demographic, familial, and lifestyle factors. Findings highlight the importance of multilevel interventions-targeting family health behaviors, maternal metabolic management, school-based physical activity promotion, and community nutrition policies-to curb the rising burden of obesity. CI - Copyright (c) 2026 Wang, Yan, Xu, Pang, Li, Chen and Ge. FAU - Wang, Wance AU - Wang W AD - The School of Physical Education and Health, East China Jiaotong University, Nanchang, China. FAU - Yan, Lei AU - Yan L AD - School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China. FAU - Xu, Bowen AU - Xu B AD - The School of Physical Education and Health, East China Jiaotong University, Nanchang, China. FAU - Pang, Xiangwei AU - Pang X AD - Jafron Biomedical Co., Ltd., Jinan, China. FAU - Li, Qianqian AU - Li Q AD - Shandong University of Art and Design, Jinan, China. FAU - Chen, Ke AU - Chen K AD - The School of Physical Education and Health, East China Jiaotong University, Nanchang, China. FAU - Ge, Renkai AU - Ge R AD - The School of Physical Education and Health, East China Jiaotong University, Nanchang, China. LA - eng PT - Journal Article DEP - 20260803 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13477887 OTO - NOTNLM OT - Shandong Province OT - childhood obesity OT - lifestyle behaviors OT - overweight OT - risk factors COIS- XP was employed by Jafron Biomedical Co., Ltd. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/18 07:46 MHDA- 2026/08/18 07:47 PMCR- 2026/08/03 CRDT- 2026/08/18 04:24 PHST- 2026/04/11 00:00 [received] PHST- 2026/07/08 00:00 [revised] PHST- 2026/07/16 00:00 [accepted] PHST- 2026/08/18 07:47 [medline] PHST- 2026/08/18 07:46 [pubmed] PHST- 2026/08/18 04:24 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - 10.3389/fnut.2026.1853192 [doi] PST - epublish SO - Front Nutr. 2026 Aug 3;13:1853192. doi: 10.3389/fnut.2026.1853192. eCollection 2026. PMID- 42606340 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20260921 IS - 1939-327X (Electronic) IS - 0012-1797 (Linking) VI - 75 IP - 10 DP - 2026 Oct 1 TI - Body Composition-Driven Phenotyping Reveals Obesity and Cardiometabolic Heterogeneity in Children Using a Tree-Like Representation. PG - 1810-1822 LID - 10.2337/db26-0136 [doi] AB - Traditional measures such as BMI do not fully capture obesity-related metabolic risks. Here, we examined DXA-derived body composition patterns in children (n = 11,238) using the discriminative dimensionality reduction tree algorithm, which was validated in an independent cohort (n = 2,001). The tree structure revealed a continuous landscape of body composition phenotypes, with distinct spatial gradients for fat and lean mass. Within the phenotypic tree, fat-dominant phenotypes clustered in the region of low dimension 1 and low dimension 2 (corresponding to the lower left branches), where they demonstrated significant spatial overlap with high-risk clusters for hypertension, elevated LDL cholesterol (LDL-C), total cholesterol, and triglycerides (TG) (Moran I >0.3, all P < 0.001). Meanwhile, phenotypes characterized by elevated lean mass coupled with increased adiposity were localized in the region of low dimension 1 and high dimension 2 (upper left branches), demonstrating an increased risk of low HDL-C and high TG (Moran I >0.6, all P < 0.001). In contrast, lean-dominant phenotypes clustered in the region of high dimension 1 and high dimension 2 (upper right branches), which were associated with a relatively low risk of hyperglycemia, insulin resistance, and high LDL-C (Moran I >0.1, all P < 0.001). For practical utility, we developed a publicly available web application to map individual data on the reference tree architecture, allowing for assessment of cardiometabolic risk. Our findings highlight the value of more precise body composition measures for early identification and prevention of obesity-related health problems. ARTICLE HIGHLIGHTS: Childhood obesity shows large differences in body composition and health risk that are not well captured by BMI or simple metabolic classifications, prompting the need for more precise characterization. This study aimed to determine whether a data-driven framework integrating detailed body composition measures could better describe obesity-related phenotypic heterogeneity and its relationship with cardiometabolic risk in children. We delineated a continuous body composition manifold encompassing fat-dominant, lean-dominant, and concomitant high-mass phenotypes, which captured diverging cardiometabolic risk trajectories and yielded modest incremental improvements in risk prediction. These findings support more precise risk stratification and provide a practical tool to improve early identification and prevention of obesity-related health complications in children. CI - (c) 2026 by the American Diabetes Association. FAU - Xiao, Pei AU - Xiao P AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Cheng, Hong AU - Cheng H AD - Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China. FAU - Xiong, Jingfan AU - Xiong J AD - Child and Adolescent Chronic Disease Prevention and Control Department, Shenzhen Center for Chronic Disease Control, Guangdong, China. FAU - Yan, Yinkun AU - Yan Y AUID- ORCID: 0000-0002-7758-744X AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Liu, Junting AU - Liu J AD - Child Health Big Data Research Center, Capital Center for Children's Health, Capital Medical University and Capital Institute of Pediatrics, Beijing, China. FAU - Liu, Li AU - Liu L AD - School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China. FAU - Dong, Hongbo AU - Dong H AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Li, Yan AU - Li Y AD - Child and Adolescent Chronic Disease Prevention and Control Department, Shenzhen Center for Chronic Disease Control, Guangdong, China. FAU - Ye, Peiyu AU - Ye P AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Fu, Liwan AU - Fu L AUID- ORCID: 0000-0002-7851-6379 AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Gao, Liwang AU - Gao L AD - School of Public Health, Capital Medical University, Beijing, China. FAU - Chen, Fangfang AU - Chen F AD - Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China. FAU - Shan, Xinying AU - Shan X AD - Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China. FAU - Lan, Lina AU - Lan L AD - Child and Adolescent Chronic Disease Prevention and Control Department, Shenzhen Center for Chronic Disease Control, Guangdong, China. FAU - Li, Yanyan AU - Li Y AD - Child and Adolescent Chronic Disease Prevention and Control Department, Shenzhen Center for Chronic Disease Control, Guangdong, China. FAU - Mi, Jie AU - Mi J AUID- ORCID: 0000-0003-0630-8447 AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. LA - eng GR - L259068/Beijing Natural Science Foundation/ GR - 82204061/National Natural Science Foundation of China/ GR - 82373589/National Natural Science Foundation of China/ GR - SZSM 202311020/Sanming Project of Medicine in Shenzhen/ GR - CFH 2026-4G-2097/Capital's Funds for Health Improvement and Research/ PT - Journal Article PL - United States TA - Diabetes JT - Diabetes JID - 0372763 RN - 0 (Triglycerides) SB - IM MH - Humans MH - *Body Composition/physiology MH - Phenotype MH - Child MH - Male MH - Female MH - *Obesity MH - Body Mass Index MH - Absorptiometry, Photon MH - Algorithms MH - Triglycerides/blood MH - Adolescent MH - Adiposity/physiology EDAT- 2026/08/17 11:40 MHDA- 2026/09/21 17:47 CRDT- 2026/08/17 09:53 PHST- 2026/02/04 00:00 [received] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/09/21 17:47 [medline] PHST- 2026/08/17 11:40 [pubmed] PHST- 2026/08/17 09:53 [entrez] AID - 172389 [pii] AID - 10.2337/db26-0136 [doi] PST - ppublish SO - Diabetes. 2026 Oct 1;75(10):1810-1822. doi: 10.2337/db26-0136. PMID- 42603809 OWN - NLM STAT- Publisher LR - 20260815 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Aug 15 TI - Associations of mental health with subsequent weight development during a 4-year follow-up in adolescence. LID - 10.1038/s41390-026-05361-1 [doi] AB - BACKGROUND: Although obesity and mental health problems represent two of the most pressing public health challenges, their developmental interplay remains insufficiently understood. Thus, we examined how depressive and anxiety symptoms, self-esteem, and psychological resilience are associated with weight development during adolescence. METHODS: We included 1280 11-year-old children from the Finnish Health in Teens cohort, following 814 of them for 4.3 years. Mental health was assessed with validated self-administered scales at age 11. Psychological resilience was determined by complete mental health after exposure to stressful life events. Body mass index z-score (BMIz) and waist-to-height ratio (WtHr) were calculated at ages 11 and 16. RESULTS: In models adjusted for sex, age, physical activity, dietary pattern, puberty status, caregivers' BMI and education level, depressive symptoms were associated with higher baseline BMIz but smaller increases in mean BMIz thereafter (p = 0.030). High self-esteem was associated with lower baseline BMIz, yet with steeper increases over follow-up (adjusted model, p = 0.021). Anxiety symptoms and resilience were not associated with BMIz after adjustments. Similar patterns were observed for WtHr. CONCLUSION: Findings highlight that mental health is associated with physical growth in adolescence, emphasizing the need to consider mental health in understanding and addressing patterns of weight development and their underlying dynamics. IMPACT: This study provides up-to-date, longitudinal evidence on how mental health shapes subsequent weight development during the critical and rapid growth period of adolescence. Both positive and negative dimensions of mental health play a role in shaping adolescent weight development, with evidence that some youths experiencing mental health difficulties exhibited smaller increases in BMI z-score, even when starting from a higher baseline BMI. It should be acknowledged that in contemporary society, adolescents with mental health difficulties may not necessarily present immediate excessive weight gain but instead follow stable or even declining weight trajectories. CI - (c) 2026. The Author(s). FAU - Ankkuri, Emilia AU - Ankkuri E AD - Folkhalsan Research Centre, Helsinki, Finland. AD - Faculty of Medicine, University of Helsinki, Helsinki, Finland. FAU - Lommi, Sohvi AU - Lommi S AD - Folkhalsan Research Centre, Helsinki, Finland. AD - Faculty of Medicine, University of Helsinki, Helsinki, Finland. FAU - Granroth-Wilding, Hanna AU - Granroth-Wilding H AD - Faculty of Medicine, University of Helsinki, Helsinki, Finland. FAU - Lahti, Jari AU - Lahti J AD - Folkhalsan Research Centre, Helsinki, Finland. AD - Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland. FAU - Viljakainen, Heli AU - Viljakainen H AD - Folkhalsan Research Centre, Helsinki, Finland. heli.viljakainen@helsinki.fi. AD - Faculty of Medicine, University of Helsinki, Helsinki, Finland. heli.viljakainen@helsinki.fi. LA - eng PT - Journal Article DEP - 20260815 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Informed consent: Written informed consent was obtained from Finnish Health in Teens participating adolescents and their caregivers. EDAT- 2026/08/16 05:35 MHDA- 2026/08/16 05:35 CRDT- 2026/08/15 23:28 PHST- 2025/09/19 00:00 [received] PHST- 2026/07/04 00:00 [accepted] PHST- 2026/06/15 00:00 [revised] PHST- 2026/08/16 05:35 [medline] PHST- 2026/08/16 05:35 [pubmed] PHST- 2026/08/15 23:28 [entrez] AID - 10.1038/s41390-026-05361-1 [pii] AID - 10.1038/s41390-026-05361-1 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Aug 15. doi: 10.1038/s41390-026-05361-1. PMID- 42602011 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260815 LR - 20260816 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Analysis of influencing factors and nomogram of attention-deficit hyperactivity disorder in school-age children. PG - 1830784 LID - 10.3389/fpsyt.2026.1830784 [doi] LID - 1830784 AB - INTRODUCTION: Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in school-aged children (6-13 years) that can lead to significant functional impairment if not identified early. This study aims to identify factors associated with ADHD among school-age children and evaluate the predictive value of a risk nomogram. METHODS: We conducted a retrospective study including 155 school-age children diagnosed with ADHD at the Minhang District Mental Health Centre (Shanghai) between June 2022 and May 2025, and 155 age-matched healthy controls who underwent physical examination during the same period. Clinical and demographic data were collected via standardized questionnaires. Logistic regression analyses were performed to identify risk factors, and a nomogram prediction model was constructed. Model performance was assessed using the area under the receiver operating characteristic curve (AUC), calibration plots, and the Hosmer-Lemeshow test. RESULTS: Multivariate logistic analysis identified maternal alcohol consumption during pregnancy (OR = 6.975), maternal smoking during pregnancy (OR = 3.785), maternal anxiety and depression during pregnancy (OR = 3.826), family history of ADHD (OR = 9.449), parental violence (OR = 3.369), difficulty falling asleep (OR = 7.317), and daily screen time >/= 2 hours (OR = 1.755) as independent risk factors for ADHD. Family harmony was identified as a protective factor (OR = 0.455). The nomogram prediction model demonstrated good discriminative ability with an AUC of 0.817 (95% CI: 0.769-0.864) at a cut-off value of logit(P) > 0.471. The model showed satisfactory calibration (Hosmer-Lemeshow test, P = 0.355) with a sensitivity of 75.48% and specificity of 76.77%. DISCUSSION: ADHD in school-age children is influenced by multiple factors, including prenatal exposures, family environment, sleep patterns, and daily screen time. The nomogram prediction model developed in this study demonstrates good predictive performance and may serve as a preliminary tool for early identification of at-risk children, though external validation is needed before clinical implementation. These findings highlight the importance of targeted preventive interventions addressing modifiable risk factors, particularly focusing on prenatal care, family harmony, sleep hygiene, and screen time management, to reduce the probability of ADHD in school-age children. CI - Copyright (c) 2026 Li, Zhang, Jiang, Tao, Wang and Jin. FAU - Li, Bo AU - Li B AD - Shanghai Minhang District Mental Health Center, Shanghai, China. FAU - Zhang, Wei Bo AU - Zhang WB AD - Shanghai Mental Health Center, Shanghai, China. FAU - Jiang, Chao AU - Jiang C AD - Shanghai Minhang District Mental Health Center, Shanghai, China. FAU - Tao, Jing AU - Tao J AD - Shanghai Mental Health Center, Shanghai, China. FAU - Wang, Li Na AU - Wang LN AD - Shanghai Minhang District Mental Health Center, Shanghai, China. FAU - Jin, Jin AU - Jin J AD - Shanghai Mental Health Center, Shanghai, China. LA - eng PT - Journal Article DEP - 20260731 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13473084 OTO - NOTNLM OT - ADHD OT - nomogram OT - prediction model OT - risk factors OT - school-aged children COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/15 05:36 MHDA- 2026/08/15 05:37 PMCR- 2026/07/31 CRDT- 2026/08/15 04:59 PHST- 2026/03/14 00:00 [received] PHST- 2026/05/30 00:00 [revised] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/08/15 05:37 [medline] PHST- 2026/08/15 05:36 [pubmed] PHST- 2026/08/15 04:59 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1830784 [doi] PST - epublish SO - Front Psychiatry. 2026 Jul 31;17:1830784. doi: 10.3389/fpsyt.2026.1830784. eCollection 2026. PMID- 42601769 OWN - NLM STAT- MEDLINE DCOM- 20260815 LR - 20260819 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 33 DP - 2026 Aug 14 TI - Central adiposity reflected by the weight-adjusted waist index and spirometric parameters in US children and adolescents: A cross-sectional analysis of NHANES 2007 to 2012. PG - e50200 LID - 10.1097/MD.0000000000050200 [doi] LID - e50200 AB - Obesity impairs pulmonary function. This study aimed to investigate the potential relationship between the weight-adjusted waist index (WWI), a novel metric for measuring adiposity, and pulmonary function in children and adolescents. This cross-sectional study used extensive data on WWI and pulmonary function metrics from the 2007 to 2012 National Health and Nutrition Examination Survey. The WWI calculation entails dividing waist circumference (cm) by the square root of weight (kg). Z-scores for each lung function measure were derived from Global Lung Function Initiative references. We employed a weighted multivariate logistic regression model to ascertain the association between lung function and WWI. The application of smooth curve fitting validated the linearity of the relationships. Subgroup analysis and evaluation of interactions were conducted as well. Across all statistical models, no significant association was observed between WWI and forced expiratory volume in 1 second (FEV1) z-score. However, WWI demonstrated a significant positive correlation with forced vital capacity (FVC) z-score. Importantly, a significant negative correlation was consistently found between WWI and FEV1/FVC z-score. In the model with all adjustments, each unit rise in WWI was associated with a decrease of 0.395 in FEV1/FVC z-score (beta = -0.395, 95% confidence interval: -0.496, -0.295) and an increase of 0.292 in FVC z-score (beta = 0.292, 95% confidence interval: 0.186, 0.398). This study finds a significant negative association between WWI and FEV1/FVC z-score. This highlights the necessity for sustained WWI surveillance to guide public health initiatives. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Wu, Meijuan AU - Wu M AD - Department of Pulmonary and Critical Care Medicine, The Second Hospital of Sanming, Sanming, Fujian Province, PR China. FAU - Xie, Qihua AU - Xie Q FAU - Zhang, Aimei AU - Zhang A FAU - Lin, Yongping AU - Lin Y LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Cross-Sectional Studies MH - Adolescent MH - Nutrition Surveys MH - Female MH - Child MH - United States/epidemiology MH - Male MH - *Waist Circumference/physiology MH - Spirometry MH - Forced Expiratory Volume/physiology MH - Vital Capacity/physiology MH - *Obesity, Abdominal/physiopathology/epidemiology MH - *Adiposity/physiology PMC - PMC13480898 OTO - NOTNLM OT - NHANES OT - children and adolescents OT - obesity OT - pulmonary function OT - weight-adjusted waist index COIS- The authors have no funding and conflicts of interest to declare. EDAT- 2026/08/15 05:36 MHDA- 2026/08/15 05:37 PMCR- 2026/08/14 CRDT- 2026/08/15 01:00 PHST- 2026/01/27 00:00 [received] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/08/15 05:37 [medline] PHST- 2026/08/15 05:36 [pubmed] PHST- 2026/08/15 01:00 [entrez] PHST- 2026/08/14 00:00 [pmc-release] AID - 00005792-202608140-00097 [pii] AID - MD-D-26-01188 [pii] AID - 10.1097/MD.0000000000050200 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Aug 14;105(33):e50200. doi: 10.1097/MD.0000000000050200. PMID- 42601187 OWN - NLM STAT- Publisher LR - 20260928 IS - 1468-6244 (Electronic) IS - 0022-2593 (Print) IS - 0022-2593 (Linking) DP - 2026 Aug 14 TI - Childhood-onset neurodegeneration and brain atrophy: defining UBTF-related developmental regression and progressive ataxia. LID - jmg-2025-111356 [pii] LID - 10.1136/jmg-2025-111356 [doi] AB - BACKGROUND: The heterozygous variant c.628G>A (p.Glu210Lys) in UBTF (upstream binding transcription factor) causes childhood-onset neurodegeneration with brain atrophy (CONDBA) (OMIM # 600673), characterised by early normal or mildly delayed development followed by regression, with individuals frequently experiencing movement disorders. This study defines the natural history of this rare disorder and explores potential biomarkers in humans and mice. METHODS: Caregivers of individuals with CONDBA completed cross-sectional surveys detailing genetic, developmental and clinical features. Patients evaluated in a neurogenetics clinic underwent Brief Ataxia Rating Scale (BARS) assessments compared with remotely collected wrist and ankle accelerometry data. Neurofilament light chain (NFL) levels were assessed in the clinic cohort and in a Ubtf E210K knock-in mouse model. RESULTS: All 11 caregiver surveys reported onset of neurodevelopmental regression (median 3.5 years, range 0.5-5 years), at times following anaesthesia or illness and 82% developed ataxia. Motor activity data from five participants (median 11.8 years, range 8.1-12.5 years) had high test-retest reliability, correlated with ataxia severity as measured by the BARS, and showed declines across multiple measures over the study period. NFL was abnormally elevated in both humans and the mouse model. CONCLUSION: UBTF-related CONDBA presents with early normal or mildly delayed development followed by regression and progressive ataxia. Wearable accelerometers provide a reliable measure of disease severity, and elevated NFL may serve as a biomarker of neuronal injury in both humans and animal models. CI - (c) Author(s) (or their employer(s)) 2026. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Nagy, Amanda AU - Nagy A AUID- ORCID: 0000-0001-8116-4805 AD - Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA anagy2@mgb.org. FAU - Luddy, Anna AU - Luddy A AD - Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Molay, Francine AU - Molay F AD - Division of Clinical Research, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - McLaughlin, Haley AU - McLaughlin H AD - Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - De La Rosa Abreu, Lizbeth AU - De La Rosa Abreu L AD - Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Becker, Catherine AU - Becker C AD - Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Terrey, Markus AU - Terrey M AD - Rare Disease Translational Center, The Jackson Laboratory, Bar Harbor, Maine, USA. FAU - Lutz, Cathleen M AU - Lutz CM AD - Rare Disease Translational Center, The Jackson Laboratory, Bar Harbor, Maine, USA. AD - JAX Center for Precision Genetics, The Jackson Laboratory, Bar Harbor, Maine, USA. FAU - Gupta, Anoopum AU - Gupta A AD - Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Eichler, Florian S AU - Eichler FS AD - Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. LA - eng GR - R01 NS134597/NS/NINDS NIH HHS/United States GR - U42 OD010921/OD/NIH HHS/United States GR - U54 NS115052/NS/NINDS NIH HHS/United States GR - U54 OD030187/OD/NIH HHS/United States PT - Journal Article DEP - 20260814 PL - England TA - J Med Genet JT - Journal of medical genetics JID - 2985087R SB - IM PMC - PMC13614006 MID - NIHMS2209294 OTO - NOTNLM OT - Central Nervous System Diseases OT - Cerebellar Diseases OT - Movement Disorders OT - Neurodegenerative Diseases OT - Pediatrics COIS- Competing interests: For the methods for extracting and characterising submovements from wearable sensor data, a PCT (US2022/081374) was filed on 12 December 2022, titled 'System and method for clinical disorder assessment'. An earlier US Provisional Application (Serial No. 63/288,619) was filed on 12 December 2021. The patent applicant is the institution (Massachusetts General Hospital) and inventor is AG. EDAT- 2026/08/14 23:37 MHDA- 2026/08/14 23:37 PMCR- 2026/09/25 CRDT- 2026/08/14 21:23 PHST- 2025/11/11 00:00 [received] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/08/14 23:37 [medline] PHST- 2026/08/14 23:37 [pubmed] PHST- 2026/08/14 21:23 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - jmg-2025-111356 [pii] AID - 10.1136/jmg-2025-111356 [doi] PST - aheadofprint SO - J Med Genet. 2026 Aug 14:jmg-2025-111356. doi: 10.1136/jmg-2025-111356. PMID- 42600070 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260814 LR - 20260816 IS - 2291-9279 (Print) IS - 2291-9279 (Electronic) VI - 14 DP - 2026 Aug 14 TI - Structured Virtual Reality Exergame Intervention in Adolescents With Mild Intellectual Disabilities: Pre-Post Pilot Study on Motor Proficiency and Reaction Time. PG - e95572 LID - 10.2196/95572 [doi] LID - e95572 AB - BACKGROUND: Adolescents with mild intellectual disabilities often exhibit deficits in motor proficiency and neurocognitive processing, which can limit their functional independence. Although virtual reality (VR) exergames provide a motivating platform for physical activity, objective data quantifying their impact on standardized motor scales remain scarce, particularly when implemented through structured pedagogical frameworks. Earlier research established the WISH (warm-up, imitation, settings, half-hour) and WON (warm-up, objective evaluation, no problem!) protocols to facilitate gameplay independence in this population. However, the extent to which this systematic approach translates into measurable clinical motor and reaction time gains requires further investigation. OBJECTIVE: This study evaluated the effectiveness of a 16-session structured VR exergame intervention, using the WISH and WON protocols, in enhancing motor proficiency and shortening simple reaction time among adolescents with mild intellectual disability. METHODS: A multisession, single-group pretest and posttest pilot design was used. A convenience sample of 8 adolescents (3 males, 5 females; mean age 17.63, SD 1.77, range 15-20 years) was recruited from a special school complex in Poland. The intervention was conducted over an 8-month period (October 2023 to May 2024), consisting of 16 sessions conducted once every 2 weeks. The rhythmic fitness game "OhShape!" (Odders Lab) was played on the Meta Quest 2 system. Motor proficiency was assessed with the Bruininks-Oseretsky Test of Motor Proficiency short form, and simple reaction time to visual and auditory stimuli was measured using a standardized Alfa-Electronics meter. Statistical analysis was performed using the Wilcoxon signed-rank test (alpha=.05). RESULTS: Total Bruininks-Oseretsky Test of Motor Proficiency scores significantly improved from a baseline mean of 69.25 (SD 6.80; 95% CI 63.56-74.94) to 80.50 (SD 5.50; 95% CI 75.90-85.10) at the posttest (P=.01; r=0.74). Based on the standardized 5-point proficiency scale, the group mean rose from 1.88 (SD .64; 95% CI 1.34-2.42) at baseline to 2.88 (SD .35; 95% CI 2.59-3.17) postintervention (P=.008; r=0.89). Furthermore, the mean simple reaction time decreased from 426.50 (SD 52.3; 95% CI 382.78-470.22) ms to 392.10 (SD 38.4; 95% CI 359.98-424.22) ms at the final assessment (P=.02; r=0.72). CONCLUSIONS: This pilot study suggests structured VR exergaming may address motor deficits in adolescents with mild intellectual disability. Promoting autonomy via protocols was associated with measurable motor gains within this cohort. Although the absence of a control group limits causal claims, immersive VR may offer a supportive tool for neuro-motor adaptations in special education, warranting validation in larger controlled trials. CI - (c) Julia Ciazynska, Agnieszka Kazimiera Rudowicz, Aneta Worska, Janusz Maciaszek. Originally published in JMIR Serious Games (https://games.jmir.org). FAU - Ciazynska, Julia AU - Ciazynska J AUID- ORCID: 0000-0001-9065-9164 AD - Department of Physical Activity and Health Promotion Science, Poznan University of Physical Education, Krolowej Jadwigi 27/39, Poznan, Poland, 48 (61) 835 50 07. FAU - Rudowicz, Agnieszka Kazimiera AU - Rudowicz AK AUID- ORCID: 0009-0002-3009-0046 AD - Special School Complex No. 102, Poznan, Poland. FAU - Worska, Aneta AU - Worska A AUID- ORCID: 0000-0003-1624-5267 AD - Department of Physical Activity and Health Promotion Science, Poznan University of Physical Education, Krolowej Jadwigi 27/39, Poznan, Poland, 48 (61) 835 50 07. FAU - Maciaszek, Janusz AU - Maciaszek J AUID- ORCID: 0000-0001-8425-5921 AD - Department of Physical Activity and Health Promotion Science, Poznan University of Physical Education, Krolowej Jadwigi 27/39, Poznan, Poland, 48 (61) 835 50 07. LA - eng PT - Journal Article DEP - 20260814 PL - Canada TA - JMIR Serious Games JT - JMIR serious games JID - 101645255 PMC - PMC13475785 OTO - NOTNLM OT - active video game OT - bilateral coordination OT - exergame OT - gross motor movements OT - health promotion OT - intellectual disabilities OT - physical activity OT - physical education OT - postural stability OT - virtual reality COIS- Conflicts of Interest: None declared. EDAT- 2026/08/14 17:39 MHDA- 2026/08/14 17:40 PMCR- 2026/08/14 CRDT- 2026/08/14 15:03 PHST- 2026/03/17 00:00 [received] PHST- 2026/07/03 00:00 [revised] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/08/14 17:40 [medline] PHST- 2026/08/14 17:39 [pubmed] PHST- 2026/08/14 15:03 [entrez] PHST- 2026/08/14 00:00 [pmc-release] AID - v14i1e95572 [pii] AID - 95572 [pii] AID - 10.2196/95572 [doi] PST - epublish SO - JMIR Serious Games. 2026 Aug 14;14:e95572. doi: 10.2196/95572. PMID- 42598598 OWN - NLM STAT- MEDLINE DCOM- 20260814 LR - 20260817 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Effects of physical activity distribution patterns on basketball skill acquisition and physical exercise self-efficacy among Chinese male university students: a randomised controlled trial. PG - e21459 LID - 10.7717/peerj.21459 [doi] LID - e21459 AB - BACKGROUND: As an open-skills sport, basketball not only enhances university students' physical fitness and specialised techniques but also influences their technical learning efficiency and exercise self-efficacy through patterns of physical activity distribution. However, empirical research on the mechanisms underlying the effects of physical activity distribution patterns on basketball technical performance and self-efficacy remains limited. OBJECTIVE: This study aims to investigate the impact of two distinct physical activity patterns (massed vs. regularly distributed) on specialised basketball skill acquisition and exercise self-efficacy among Chinese male university students. METHOD: A randomised controlled trial design was employed, enrolling 105 male university students aged 18-25 years. The participants were randomly assigned to either a massed training group or a regularly distributed training group. Both interventions lasted 8 weeks, followed by a 2-month follow-up period. Training volume and intensity were maintained at equivalent levels, differing solely in the distribution of practice sessions. Basketball skill acquisition was assessed through shooting accuracy, dribbling agility, and passing precision, whereas psychological efficacy was measured via the Revised Self-Efficacy Scale for Physical Exercise. Generalised estimating equation (GEE) and simple effects analyses were employed to examine between-group and within-group differences, controlling for potential confounding factors. RESULTS: The findings indicate that the regularly distributed training group demonstrated significantly greater improvements than did the massed training group in shooting (odds ratio (OR) = 2.316, P < 0.001), passing (OR = 1.608, P < 0.001), and self-efficacy (OR = 2.691, P = 0.001), with partial effects persisting two months post-intervention. Both groups demonstrated improvements in dribbling performance, although the differences between groups were not statistically significant. CONCLUSION: A regularly distributed physical activity pattern has greater advantages in promoting basketball-specific skills (particularly shooting and passing) and physical exercise self-efficacy. This suggests that basketball training programmes should prioritise optimising practice distribution to increase skill acquisition quality and sustain long-term exercise motivation. Future research may extend to different gender and age groups while incorporating game performance metrics to further validate the efficacy of distributed practice. CI - (c)2026 Liu et al. FAU - Liu, Zhuoxiao AU - Liu Z AD - Strength and Conditioning Training College, Beijing Sports University, Haidian, Beijing, China. AD - School of Physical Education, Shanghai University of Sport, Yangpu, Shanghai, China. FAU - Zhou, Chengyu AU - Zhou C AD - Strength and Conditioning Training College, Beijing Sports University, Haidian, Beijing, China. AD - School of Physical Education, Shanghai University of Sport, Yangpu, Shanghai, China. FAU - Zeng, Zhuo AU - Zeng Z AD - Strength and Conditioning Training College, Beijing Sports University, Haidian, Beijing, China. FAU - Yang, Huaibo AU - Yang H AD - Department of Physical Education, Hongshan College of Nanjing University of Finance and Economics, Nanjing, Jiangsu, China. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260810 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 RN - Chinese people SB - IM MH - Humans MH - Male MH - *Basketball/psychology MH - *Self Efficacy MH - Young Adult MH - Adult MH - Adolescent MH - *Exercise/psychology MH - Universities MH - *Students/psychology MH - China MH - *Athletic Performance MH - East Asian People PMC - PMC13471745 OTO - NOTNLM OT - Basketball OT - Distributed practice OT - Physical activity patterns OT - Physical exercise self-efficacy OT - Technical performance COIS- The authors declare there are no competing interests. EDAT- 2026/08/14 12:16 MHDA- 2026/08/14 12:17 PMCR- 2026/08/10 CRDT- 2026/08/14 08:02 PHST- 2025/11/24 00:00 [received] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/08/14 12:17 [medline] PHST- 2026/08/14 12:16 [pubmed] PHST- 2026/08/14 08:02 [entrez] PHST- 2026/08/10 00:00 [pmc-release] AID - 21459 [pii] AID - 10.7717/peerj.21459 [doi] PST - epublish SO - PeerJ. 2026 Aug 10;14:e21459. doi: 10.7717/peerj.21459. eCollection 2026. PMID- 42595859 OWN - NLM STAT- MEDLINE DCOM- 20260814 LR - 20260912 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 9 DP - 2026 Aug 13 TI - Is watchful waiting an alternative to adenotonsillectomy in children with mild to moderate obstructive sleep apnoea? LID - 10.1007/s00431-026-07330-6 [doi] LID - 663 AB - Adenotonsillectomy (ATE) has traditionally been the first-line treatment for obstructive sleep apnoea (OSA) in children. Increasing evidence suggests that many children with mild to moderate OSA may improve without surgery. This mini-review examines whether watchful waiting is a safe and effective alternative to ATE in otherwise healthy children with mild to moderate OSA. We searched PubMed from inception to January 2026 for randomised controlled trials (RCTs) comparing ATE with watchful waiting in children aged 1-16 years with OSA or sleep-disordered breathing confirmed by polysomnography or a validated symptom score. Two reviewers independently screened and extracted data. Results were analysed qualitatively. Five RCTs (seven published reports; n = 1287 children; mean age 6.1 years) met inclusion criteria. Spontaneous OSA resolution occurred in 44-55% of children managed with watchful waiting, compared with 57-79% following ATE. ATE produced statistically greater reductions in the apnoea-hypopnoea index in four of five trials, but between-group differences were modest. The largest and most consistent effects of ATE were seen for OSA symptom scores. CONCLUSION: Watchful waiting is a reasonable option for young, nonobese children with mild OSA, given the relatively high rates of spontaneous resolution. ATE remains appropriate for children with moderate to severe OSA. Shared decision-making, individualised care and close follow-up are essential when watchful waiting is chosen. WHAT IS KNOWN: * Otherwise healthy children with obstructive sleep apnoea due to adenotonsillar hyperplasia are usually managed with adenotonsillectomy. * Young, non-obese, Caucasian children with more mild obstructive sleep apnoea, however, showed a surprisingly high probability of spontaneous resolution of the disease in one study. WHAT IS NEW: * High rates of spontaneous resolution of obstructive sleep apnoea were observed in four independent studies, ranging from 44% to 55%. * Watchful waiting for several months may, thus, be a reasonable management option in a particular low-risk group of children with obstructive sleep apnoea. CI - (c) 2026. The Author(s). FAU - Kuhle, Stefan AU - Kuhle S AD - Institute of Clinical Epidemiology, Public Health, Health Economics, Medical Statistics and Informatics, Medical University of Innsbruck, Innsbruck, Austria. FAU - Poets, Christian F AU - Poets CF AD - Department of Neonatology and Division of Paediatric Sleep Medicine, University Children's Hospital, Tubingen, Germany. FAU - Urschitz, Michael S AU - Urschitz MS AD - Division of Paediatric Epidemiology, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Centre of the Johannes Gutenberg-University, Mainz, Germany. urschitz@uni-mainz.de. LA - eng PT - Journal Article PT - Review DEP - 20260813 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Watchful Waiting MH - *Sleep Apnea, Obstructive/therapy/surgery MH - *Adenoidectomy MH - *Tonsillectomy MH - Child MH - Child, Preschool MH - Polysomnography MH - Randomized Controlled Trials as Topic MH - Severity of Illness Index MH - Treatment Outcome MH - Adolescent PMC - PMC13473323 OTO - NOTNLM OT - Adenotonsillectomy OT - Apnoea OT - Children OT - Polysomnography OT - Sleep OT - Watchful waiting COIS- Declarations. Ethics approval, accordance, consent to participate and consent to publish: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/08/14 05:38 MHDA- 2026/08/14 05:39 PMCR- 2026/08/13 CRDT- 2026/08/13 23:55 PHST- 2026/03/23 00:00 [received] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/08/03 00:00 [revised] PHST- 2026/08/14 05:39 [medline] PHST- 2026/08/14 05:38 [pubmed] PHST- 2026/08/13 23:55 [entrez] PHST- 2026/08/13 00:00 [pmc-release] AID - 10.1007/s00431-026-07330-6 [pii] AID - 7330 [pii] AID - 10.1007/s00431-026-07330-6 [doi] PST - epublish SO - Eur J Pediatr. 2026 Aug 13;185(9):663. doi: 10.1007/s00431-026-07330-6. PMID- 42595669 OWN - NLM STAT- MEDLINE DCOM- 20261001 LR - 20261005 IS - 2529-993X (Electronic) IS - 2529-993X (Linking) VI - 44 IP - 8 DP - 2026 Oct TI - Evaluation of risk factors and development of a predictive clinical score for TB contact tracing in Angola. PG - 503251 LID - S2529-993X(26)00152-8 [pii] LID - 10.1016/j.eimce.2026.503251 [doi] AB - INTRODUCTION: Contact tracing for tuberculosis (TB) is an essential component of public health efforts to detect secondary cases and interrupt transmission chains. This study aimed to assess the risk factors associated with TB diagnosis and to develop a predictive clinical score for TB diagnosis among contacts of people with TB attending the outpatient clinic at Hospital Nossa Senhora da Paz (HNSP) in Cubal, Angola. METHODS: Prospective observational study including TB contacts of all ages. Data were analyzed using descriptive and inferential statistics, including multivariable logistic regression with multiple imputation for missing data. The performance of the proposed clinical score was assessed through ROC analysis, calibration, bootstrap internal validation, and comparison with the WHO symptom-based screening approach. RESULTS: Two-hundred and eighty-five TB contacts were included. Fifty (17.5%) contacts were diagnosed with TB, 40 (80%) of whom were children /=6 points, the score showed a sensitivity of 94% and a specificity of 75%, with an area under the ROC curve of 0.89 (95% CI: 0.85-0.94). CONCLUSIONS: These findings highlight the high burden of TB among close contacts and the challenges in properly assessing them. An easy-to-use clinical score may support frontline health workers in improving TB contact tracing in settings with high burden of disease and limited resources, such as Angola. CI - Copyright (c) 2026 Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica. Published by Elsevier Espana, S.L.U. All rights reserved. FAU - Martinez-Camprecios, Joan AU - Martinez-Camprecios J AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Tuberculosis Unit, Hospital Nossa Senhora da Paz, Cubal, Benguela, Angola. FAU - Aznar, Maria Luisa AU - Aznar ML AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Tuberculosis Unit, Hospital Nossa Senhora da Paz, Cubal, Benguela, Angola; Centro de Investigacion Biomedica en Red de Enfermedades (CIBER), Infecciosas, Instituto de Salud Carlos III, Madrid, Spain; Grupo de Estudio de Micobacterias, Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica (SEIMC), Madrid, Spain. Electronic address: maria.aznar@vhir.org. FAU - Espinosa-Pereiro, Juan AU - Espinosa-Pereiro J AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Grupo de Estudio de Micobacterias, Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica (SEIMC), Madrid, Spain; Damien Foundation, Brussels, Belgium. FAU - Aixut, Sandra AU - Aixut S AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Pediatric Unit, Hospital Nossa Senhora da Paz, Cubal, Benguela, Angola. FAU - Nindia, Arlete AU - Nindia A AD - Laboratory Department, Hospital Nossa Senhora da Paz, Cubal, Benguela, Angola. FAU - Zakarias, Adriano AU - Zakarias A AD - Tuberculosis Unit, Hospital Nossa Senhora da Paz, Cubal, Benguela, Angola. FAU - Gonzalez-Farias, Inigo AU - Gonzalez-Farias I AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Tuberculosis Unit, Hospital Nossa Senhora da Paz, Cubal, Benguela, Angola. FAU - Comella, Patricia AU - Comella P AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain. FAU - Sicaleta, Nicolau AU - Sicaleta N AD - Pediatric Unit, Hospital Nossa Senhora da Paz, Cubal, Benguela, Angola. FAU - Sanchez-Montalva, Adrian AU - Sanchez-Montalva A AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Centro de Investigacion Biomedica en Red de Enfermedades (CIBER), Infecciosas, Instituto de Salud Carlos III, Madrid, Spain; Grupo de Estudio de Micobacterias, Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica (SEIMC), Madrid, Spain. FAU - Molina, Israel AU - Molina I AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Centro de Investigacion Biomedica en Red de Enfermedades (CIBER), Infecciosas, Instituto de Salud Carlos III, Madrid, Spain. LA - eng PT - Journal Article PT - Observational Study DEP - 20260813 PL - Spain TA - Enferm Infecc Microbiol Clin (Engl Ed) JT - Enfermedades infecciosas y microbiologia clinica (English ed.) JID - 101777541 SB - IM MH - Humans MH - Angola/epidemiology MH - Risk Factors MH - *Contact Tracing/methods MH - Prospective Studies MH - *Tuberculosis/diagnosis/epidemiology/transmission MH - Female MH - Male MH - Adolescent MH - Child MH - Adult MH - Child, Preschool MH - Young Adult MH - Middle Aged MH - Infant OTO - NOTNLM OT - Contact-tracing OT - Estudio de contactos OT - Factores de riesgo OT - Risk factors OT - Tuberculosis EDAT- 2026/08/13 23:36 MHDA- 2026/10/01 23:30 CRDT- 2026/08/13 21:58 PHST- 2026/01/27 00:00 [received] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/10/01 23:30 [medline] PHST- 2026/08/13 23:36 [pubmed] PHST- 2026/08/13 21:58 [entrez] AID - S2529-993X(26)00152-8 [pii] AID - 10.1016/j.eimce.2026.503251 [doi] PST - ppublish SO - Enferm Infecc Microbiol Clin (Engl Ed). 2026 Oct;44(8):503251. doi: 10.1016/j.eimce.2026.503251. Epub 2026 Aug 13. PMID- 42594584 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260923 IS - 1873-5711 (Electronic) IS - 1050-6411 (Linking) VI - 90 DP - 2026 Oct TI - Nonimpaired literature-derived scaling does not accurately represent the shoulder and elbow strength of children and adults with paraplegia. PG - 103197 LID - S1050-6411(26)00094-5 [pii] LID - 10.1016/j.jelekin.2026.103197 [doi] AB - This study evaluated whether participant characteristics, literature-derived regression equations, and a generic musculoskeletal model developed for nonimpaired populations could accurately predict maximal shoulder and elbow strength in children and adults with paraplegia. Thirty individuals with paraplegia (22 adults, 8 children) completed maximal voluntary isometric contractions (MVICs) in seven upper extremity postures. Predicted MVICs were generated using a scaled OpenSim upper extremity model with three muscle activation inputs (Full, Separated, and EMG-informed). Linear mixed-effects models evaluated relationships between predicted and experimentally measured MVICs across postures. Model performance was assessed using marginal and conditional R(2), root mean square error (RMSE), mean absolute error (MAE), Lin's concordance correlation coefficient (CCC), and repeated-measures Bland-Altman analyses. Agreement between measured and height-predicted upper extremity segment lengths was also evaluated. Joint posture significantly influenced measured MVIC, and significant posture-by-predicted MVIC interactions demonstrated that prediction accuracy was posture dependent (all p < 0.001). The Full activation input explained the greatest proportion of variance in measured MVIC (marginal R(2) = 0.770; conditional R(2) = 0.931), whereas the EMG-informed activation input produced the lowest prediction error (RMSE = 22.38% MVIC; MAE = 17.14% MVIC). However, agreement between predicted and measured MVIC remained modest across all activation inputs (CCC = 0.259-0.312), with systematic bias evident in Bland-Altman analyses. Height-based anthropometric scaling overestimated forearm and humerus lengths by 1.25 and 4.96 cm, respectively, with greater error for the humerus (RMSE = 5.82 cm). Regression-based scaling and generic musculoskeletal models derived from nonimpaired populations provided only modest estimates of maximal upper extremity strength in individuals with paraplegia. Improving strength prediction will require innovative scaling approaches that incorporate participant-specific anthropometry, population-specific muscle properties, and individualized neuromuscular activation while balancing model accuracy with practical clinical feasibility. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Zhao, Hanhsen AU - Zhao H AD - Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, USA. FAU - Cho, Yeajin AU - Cho Y AD - Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, USA. FAU - Schnorenberg, Alyssa J AU - Schnorenberg AJ AD - Department of Biomedical Engineering, University of Wisconsin-Milwaukee, Milwaukee, WI, USA; Department of Occupational Science and Technology, College of Health Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA. FAU - Slavens, Brooke A AU - Slavens BA AD - Department of Biomedical Engineering, University of Wisconsin-Milwaukee, Milwaukee, WI, USA; Department of Occupational Science and Technology, College of Health Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA. FAU - Peterson, Carrie L AU - Peterson CL AD - Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: clpeterson@vcu.edu. LA - eng PT - Journal Article DEP - 20260810 PL - England TA - J Electromyogr Kinesiol JT - Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology JID - 9109125 SB - IM MH - Humans MH - *Paraplegia/physiopathology MH - Child MH - Male MH - Female MH - Adult MH - *Muscle Strength/physiology MH - Isometric Contraction/physiology MH - *Muscle, Skeletal/physiopathology MH - *Elbow Joint/physiopathology MH - *Models, Biological MH - *Shoulder Joint/physiopathology MH - Reproducibility of Results MH - Sensitivity and Specificity OTO - NOTNLM OT - Musculoskeletal modeling OT - Peak isometric moment OT - Spinal cord injury OT - Upper extremity COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/13 23:36 MHDA- 2026/09/23 23:55 CRDT- 2026/08/13 18:05 PHST- 2025/06/30 00:00 [received] PHST- 2026/07/30 00:00 [revised] PHST- 2026/08/09 00:00 [accepted] PHST- 2026/09/23 23:55 [medline] PHST- 2026/08/13 23:36 [pubmed] PHST- 2026/08/13 18:05 [entrez] AID - S1050-6411(26)00094-5 [pii] AID - 10.1016/j.jelekin.2026.103197 [doi] PST - ppublish SO - J Electromyogr Kinesiol. 2026 Oct;90:103197. doi: 10.1016/j.jelekin.2026.103197. Epub 2026 Aug 10. PMID- 42592038 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260814 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 7 DP - 2026 Jul 31 TI - Correlation of body mass index and serum 25-hydroxyvitamin D levels with advanced bone age in children from northwest China: a cross-sectional study. PG - 266 LID - 10.21037/tp-2026-0378 [doi] LID - 266 AB - BACKGROUND: The relationship between advanced bone age (BA), obesity, and vitamin D status remains understudied in preschool Asian children, particularly in economically developing regions. This study examined the associations of overweight/obesity and vitamin D deficiency with advanced BA among children in northwest China. METHODS: A cross-sectional study was conducted involving 1,462 children aged 3-12 years who underwent physical examinations at Gansu Provincial Maternity and Child-Care Hospital (February 2019-October 2023). BA was assessed via left wrist X-ray using the Tanner-Whitehouse 3 (TW3) RUS (radius, ulna, and short bones) method, with inter-rater reliability verified by an intraclass correlation coefficient (ICC) of 0.92 (discrepancies resolved by a third senior pediatrician). Serum 25-hydroxyvitamin D [25(OH)D] was measured using electrochemical luminescence immunoassay [Cobas e601, Roche Diagnostics; detection range: 3-100 ng/mL; intra-batch coefficient of variation (CV) <3%; inter-batch CV <5%]. Advanced BA was defined as the difference between BA and chronological age (CA) (BA-CA; BA minus CA) >1 year. The definition of advanced BA as BA-CA >1 year is widely adopted in clinical pediatric practice in China. RESULTS: The prevalence of advanced BA was 7.9%, with significantly higher rates in girls (11.9% vs. 3.4% in boys, P<0.001), children aged 9-12 years (19.4%), and those with overweight (17.1%) or obesity (16.9%) compared to normal weight children (5.8%, P<0.001). Body mass index (BMI) was positively correlated with advanced BA (Spearman rho=0.361, P<0.001) and exhibited moderate predictive value for advanced BA [area under the curve (AUC) =0.735; 95% confidence interval (CI): 0.684-0.786]. Overweight and obesity were associated with increased odds of advanced BA after adjustment for age and sex [overweight: odds ratio (OR) =2.49, 95% CI: 1.435-4.314, P<0.05; obesity: OR =2.33, 95% CI: 1.463-3.71, P<0.001], whereas serum 25(OH)D levels showed no significant association. CONCLUSIONS: Overweight and obesity were significantly associated with advanced BA in this cross-sectional cohort of children from northwest China, whereas no significant association was detected between serum 25(OH)D and advanced BA. These findings highlight the importance of nutritional monitoring for healthy skeletal development in economically transitioning regions. CI - (c) AME Publishing Company. FAU - Li, Tingting AU - Li T AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Nan, Nan AU - Nan N AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Wei, Wenjie AU - Wei W AD - Academy of Fine Art & Design, Northwest Normal University, Lanzhou, China. FAU - Zhu, Yin AU - Zhu Y AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Huang, Lei AU - Huang L AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Ma, Xuerong AU - Ma X AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Du, Yongxia AU - Du Y AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Zhang, Naqi AU - Zhang N AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - An, Dandan AU - An D AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Bai, Wenjie AU - Bai W AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Fan, Hongyan AU - Fan H AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Wang, Chen AU - Wang C AD - Department of Scientific and Technological Development, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Da, Zhenqiang AU - Da Z AD - Department of Medical Administration, Gansu Provincial Cancer Hospital, Lanzhou, China. FAU - Xie, Xingwen AU - Xie X AUID- ORCID: 0009-0006-2454-635X AD - Department of Orthopedics, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, China. LA - eng PT - Journal Article DEP - 20260629 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13462753 OTO - NOTNLM OT - Body mass index (BMI) OT - bone age (BA) OT - children OT - northwest China OT - serum 25-hydroxyvitamin D [serum 25(OH)D] COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0378/coif). The authors have no conflicts of interest to declare. EDAT- 2026/08/13 12:42 MHDA- 2026/08/13 12:43 PMCR- 2026/07/31 CRDT- 2026/08/13 06:56 PHST- 2026/04/16 00:00 [received] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/08/13 12:43 [medline] PHST- 2026/08/13 12:42 [pubmed] PHST- 2026/08/13 06:56 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - tp-15-07-266 [pii] AID - 10.21037/tp-2026-0378 [doi] PST - ppublish SO - Transl Pediatr. 2026 Jul 31;15(7):266. doi: 10.21037/tp-2026-0378. Epub 2026 Jun 29. PMID- 42592010 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260814 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 7 DP - 2026 Jul 31 TI - Development of a parsimonious predictive model for height gain outcome in children with central precocious puberty following gonadotropin-releasing hormone agonist therapy. PG - 284 LID - 10.21037/tp-2026-0254 [doi] LID - 284 AB - BACKGROUND: Central precocious puberty (CPP) is associated with compromised adult height if untreated, and gonadotropin-releasing hormone agonist (GnRHa) therapy remains the standard treatment. However, height gain during treatment varies considerably among patients, and clinically practical tools for early identification of children at risk for suboptimal growth response are lacking. This study aimed to identify prognostic determinants of suboptimal height gain during GnRHa therapy and to develop a parsimonious predictive model to facilitate evidence-based clinical decision-making and optimal intervention timing. METHODS: A retrospective cohort study was conducted enrolling children with CPP treated with triptorelin. Baseline clinical and biochemical parameters were collected, including chronological age, height standard deviation score (SDS), body mass index (BMI) SDS, insulin-like growth factor-1 (IGF-1) SDS, bone age advancement [bone age minus chronological age (BA-CA)], Tanner stage, GnRH-stimulated luteinizing hormone (LH) peak, and serum estradiol concentrations. Patients were stratified into favorable and unfavorable outcome cohorts based on height gain during treatment. Univariate and multivariable logistic regression analyses were performed to identify independent predictors. Three predictive models were constructed: M0 (comprehensive model with five predictors: IGF-1 SDS, BMI SDS, BA-CA, Tanner stage, and age), M1 (univariate model with IGF-1 SDS), and M2 (parsimonious model with IGF-1 SDS and BA-CA). Model performance was assessed using receiver operating characteristic (ROC) curves, calibration plots, decision curve analysis (DCA; 1-50% risk thresholds), and bootstrap internal validation. RESULTS: A total of 163 children with CPP were enrolled (favorable outcome: n=113; unfavorable outcome: n=50). Multivariable logistic regression identified BMI SDS [odds ratio (OR) =2.33, 95% confidence interval (CI): 1.14-4.76, P=0.02], IGF-1 SDS (OR =1.94, 95% CI: 1.24-3.02, P=0.004), and bone age advancement (OR =21.49, 95% CI: 5.41-85.30, P<0.001) as independent predictors for unfavorable outcome. The area under the curve (AUC) was 0.838 (95% CI: 0.774-0.903) for M0, 0.664 (95% CI: 0.573-0.754) for M1, and 0.815 (95% CI: 0.748-0.883) for M2. DeLong test revealed no significant difference between M2 and M0 (DeltaAUC =-0.023, P=0.24). Bootstrap internal validation (1,000 iterations) demonstrated optimism-corrected AUC values of 0.810, 0.661, and 0.807 for M0, M1, and M2, respectively. M2 exhibited optimal calibration slope (0.957, 95% CI: 0.642-1.389) closest to unity. Brier scores were 0.160 for M0 and 0.167 for M2. DCA demonstrated comparable clinical net benefit for M0 and M2 across 1-50% risk thresholds. CONCLUSIONS: The parsimonious model (M2) incorporating IGF-1 SDS and bone age advancement demonstrates robust predictive capability for height gain outcome in children with CPP receiving GnRHa therapy, comparable to the comprehensive model. This model may support early risk stratification and closer growth monitoring in selected patients; however, external validation and confirmation against final adult height outcomes are required before it can inform decisions about adjunctive interventions. CI - (c) AME Publishing Company. FAU - Lin, Xiaohong AU - Lin X AD - Department of Pediatrics, Yueqing Maternal and Child Health Hospital, Yueqing, China. FAU - Lin, Kai AU - Lin K AD - Department of Radiology, Yueqing Maternal and Child Health Hospital, Yueqing, China. FAU - Ye, Pengcheng AU - Ye P AD - Department of Pediatrics, Yueqing Maternal and Child Health Hospital, Yueqing, China. FAU - Wang, Ben AU - Wang B AD - Department of Laboratory, Yueqing Maternal and Child Health Hospital, Yueqing, China. FAU - Huang, Chongbin AU - Huang C AD - Department of Pediatrics, Yueqing Maternal and Child Health Hospital, Yueqing, China. FAU - Hong, Jianyu AU - Hong J AD - Department of Pediatrics, Yueqing Maternal and Child Health Hospital, Yueqing, China. FAU - Xue, Yunyun AU - Xue Y AD - Department of Medical Affairs, Yueqing Maternal and Child Health Hospital, Yueqing, China. FAU - Qian, Xiaoquan AU - Qian X AUID- ORCID: 0009-0002-9549-5677 AD - Department of Pathology, Yueqing Maternal and Child Health Hospital, Yueqing, China. LA - eng PT - Journal Article DEP - 20260727 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13462843 OTO - NOTNLM OT - Central precocious puberty (CPP) OT - bone age OT - gonadotropin-releasing hormone agonist (GnRHa) OT - height outcome OT - insulin-like growth factor-1 (IGF-1) COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0254/coif). The authors have no conflicts of interest to declare. EDAT- 2026/08/13 12:42 MHDA- 2026/08/13 12:43 PMCR- 2026/07/31 CRDT- 2026/08/13 06:52 PHST- 2026/03/12 00:00 [received] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/08/13 12:43 [medline] PHST- 2026/08/13 12:42 [pubmed] PHST- 2026/08/13 06:52 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - tp-15-07-284 [pii] AID - 10.21037/tp-2026-0254 [doi] PST - ppublish SO - Transl Pediatr. 2026 Jul 31;15(7):284. doi: 10.21037/tp-2026-0254. Epub 2026 Jul 27. PMID- 42591968 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260814 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 7 DP - 2026 Jul 31 TI - An interpretable machine learning model based on routine clinical indicators for early identification of obesity-related non-alcoholic fatty liver disease in children: a single-center retrospective study. PG - 275 LID - 10.21037/tp-2026-0371 [doi] LID - 275 AB - BACKGROUND: There is still a lack of a noninvasive, individualized tool to pre-screen children with obesity for the risk of non-alcoholic fatty liver disease (NAFLD) and to prioritize referral for confirmatory abdominal ultrasonography. In this study, we aimed to develop and interpret a machine learning (ML)-based model for predicting ultrasound-defined NAFLD risk among children with obesity using routine clinical and biochemical indicators. METHODS: This single-center retrospective study included 439 obese children treated at Siyang Hospital between February 2021 and December 2025. Demographic, anthropometric, and routine laboratory indicators were collected, and ultrasound-defined NAFLD was used as the study outcome. Least absolute shrinkage and selection operator (LASSO) regression and the Boruta algorithm were applied to identify robust predictive features, and six ML models-logistic regression, decision tree, random forest, extreme gradient boosting (XGBoost), light gradient boosting machine (LightGBM), and support vector machine (SVM)-were developed and compared to determine the optimal model. Model performance was evaluated in the test set, and Shapley Additive exPlanations (SHAP) was used to interpret the final model. RESULTS: A total of 439 obese children were included in the analysis, of whom 206 (46.9%) had ultrasound-defined NAFLD. Seven variables were selected to develop six ML models. Among these, the LightGBM model showed the best overall performance across multiple metrics, with comparable discrimination among the top models in the test set, with an area under the curve (AUC) of 0.870, accuracy of 0.823, precision of 0.828, sensitivity of 0.787, specificity of 0.855, and F1 score of 0.807. SHAP analysis further demonstrated that waist-to-height ratio contributed most to the model output, followed by body mass index (BMI), triglyceride-glucose index x waist circumference (TyG-WC), serum uric acid, and triglyceride-glucose index x body mass index (TyG-BMI). CONCLUSIONS: This study developed an interpretable ML-based model for predicting ultrasound-defined NAFLD risk in obese children using routine clinical and biochemical indicators. LightGBM showed the best overall predictive performance, with good calibration and potential clinical utility. It may serve as a noninvasive auxiliary tool to pre-screen children with obesity and prioritize referral for confirmatory abdominal ultrasonography, supporting early identification and risk assessment of ultrasound-defined NAFLD, although further multicenter prospective studies and external validation are still needed before broader clinical application. CI - (c) AME Publishing Company. FAU - Zhuang, Lili AU - Zhuang L AD - Department of Pediatrics, Siyang Hospital, Suqian, China. FAU - Dai, Jinxing AU - Dai J AD - Department of Pediatrics, Siyang Hospital, Suqian, China. FAU - Wang, Jiajia AU - Wang J AD - Cancer Center, Siyang Hospital, Suqian, China. FAU - Shi, Qianjin AU - Shi Q AD - Cancer Center, Siyang Hospital, Suqian, China. FAU - Shen, Kang AU - Shen K AD - Cancer Center, Siyang Hospital, Suqian, China. FAU - Qiu, Hao AU - Qiu H AD - Cancer Center, Siyang Hospital, Suqian, China. FAU - Qiu, Weibing AU - Qiu W AD - Department of Pediatrics, Siyang Hospital, Suqian, China. LA - eng PT - Journal Article DEP - 20260627 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13462896 OTO - NOTNLM OT - Childhood obesity OT - Shapley Additive exPlanations (SHAP) OT - light gradient boosting machine (LightGBM) OT - machine learning (ML) OT - non-alcoholic fatty liver disease (NAFLD) COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0371/coif). The authors have no conflicts of interest to declare. EDAT- 2026/08/13 12:43 MHDA- 2026/08/13 12:44 PMCR- 2026/07/31 CRDT- 2026/08/13 06:48 PHST- 2026/04/17 00:00 [received] PHST- 2026/06/05 00:00 [accepted] PHST- 2026/08/13 12:44 [medline] PHST- 2026/08/13 12:43 [pubmed] PHST- 2026/08/13 06:48 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - tp-15-07-275 [pii] AID - 10.21037/tp-2026-0371 [doi] PST - ppublish SO - Transl Pediatr. 2026 Jul 31;15(7):275. doi: 10.21037/tp-2026-0371. Epub 2026 Jun 27. PMID- 42591247 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260814 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - The impact of physical activity on executive function in college students: the chain mediating role of anxiety and sleep quality. PG - 1853278 LID - 10.3389/fpsyg.2026.1853278 [doi] LID - 1853278 AB - BACKGROUND AND OBJECTIVES: Executive function (EF) serves as a critical regulatory hub for goal-directed behavior, yet its operational integrity is increasingly threatened by the sedentary lifestyles and psychological stressors prevalent in higher education. While the cognitive benefits of exercise are documented, the specific pathways through which it navigates psychological and physiological barriers remain underexplored. This study constructs a chain mediation model to elucidate how physical activity (PA) optimizes EF by sequentially modulating anxiety and sleep quality (SQ) among university students. METHODS: Data collection was conducted in December 2025, involving a multi-stage cluster convenience sample of 2,033 students across six Chinese provinces. Participants (mean age 19.0 +/- 1.1) completed a battery of validated instruments, including the Single-Item Measure for PA, the GAD-2 for anxiety, the Single-Item Sleep Quality Scale, and the Adolescent Executive Function Scale. Structural relationships were analyzed using the SPSS PROCESS macro (Model 6) while controlling for demographic covariates such as gender, age, and socioeconomic background. RESULTS: Path analysis confirmed that PA positively predicts EF proficiency, with the direct effect accounting for 49.53% of the total variance. Beyond this direct link, the relationship is substantiated by three distinct mediating trajectories: (1) a psychological pathway via anxiety reduction (31.78%), (2) a physiological pathway via enhanced sleep quality (14.02%), (3) a sequential chain pathway wherein PA alleviates anxiety, which subsequently optimizes sleep, leading to superior executive performance (4.67%). All mediating effects reached statistical significance as evidenced by bootstrap confidence intervals. CONCLUSION: These findings transition the understanding of physical intervention from a unilinear correlation to a multi-systemic synergistic response. Exercise functions not only as a cognitive catalyst but also as a vital buffer that prevents the maladaptive depletion of neural resources by stabilizing emotional oscillations and facilitating physiological restoration. The results underscore the necessity for higher education institutions to integrate physical activity, psychological counseling, and sleep hygiene management into a cohesive framework for cognitive health. CI - Copyright (c) 2026 Li, Wan, Ru, Wang, Wang, Liu, Liang, Zhang and Bao. FAU - Li, Yuhao AU - Li Y AD - Beijing Sport University, Beijing, China. FAU - Wan, Xiaotong AU - Wan X AD - School of Nursing, Anhui Medical University, Hefei, China. FAU - Ru, Aojie AU - Ru A AD - School of Nursing, Anhui Medical University, Hefei, China. FAU - Wang, Yanfei AU - Wang Y AD - Department of Science and Education, Xilingol League Central Hospital, Xilinhot, China. FAU - Wang, Jing AU - Wang J AD - Department of Anesthesiology for Surgery, Xilingol League Central Hospital, Xilinhot, China. FAU - Liu, Yang AU - Liu Y AD - Jishou University, Jishou, China. FAU - Liang, Zhiru AU - Liang Z AD - Department of Hepatobiliary Surgery, Xilingol League Central Hospital, Xilinhot, China. FAU - Zhang, Hui AU - Zhang H AD - School of Nursing, Anhui Medical University, Hefei, China. AD - Department of Nursing, The First Affiliated Hospital of Anhui Medical University (Anhui Public Health Clinical Center), Hefei, China. FAU - Bao, Yin AU - Bao Y AD - Department of Hepatobiliary Surgery, Xilingol League Central Hospital, Xilinhot, China. LA - eng PT - Journal Article DEP - 20260729 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13461551 OTO - NOTNLM OT - anxiety OT - chain mediation OT - college students OT - executive function OT - physical activity OT - sleep quality COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/13 12:42 MHDA- 2026/08/13 12:43 PMCR- 2026/07/29 CRDT- 2026/08/13 05:22 PHST- 2026/04/11 00:00 [received] PHST- 2026/07/01 00:00 [revised] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/08/13 12:43 [medline] PHST- 2026/08/13 12:42 [pubmed] PHST- 2026/08/13 05:22 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1853278 [doi] PST - epublish SO - Front Psychol. 2026 Jul 29;17:1853278. doi: 10.3389/fpsyg.2026.1853278. eCollection 2026. PMID- 42589895 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260815 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 15 DP - 2026 Jul 24 TI - Strong Family-Level Clustering of Adolescent Weight Status Despite Limited Associations with Individual Parental Anthropometric and Metabolic Characteristics. LID - 10.3390/jcm15155790 [doi] LID - 5790 AB - Objectives: Familial aggregation of obesity has been consistently reported; however, previous studies have predominantly relied on body mass index (BMI)-based associations and have dedicated insufficient time to examining the contribution of measurable parental biological traits to family-level clustering. We investigated associations between parental anthropometric and metabolic characteristics and adolescent weight status in families in which at least one parent had obesity, while exploring family-level clustering patterns. Methods: This cross-sectional family-based study included 34 families comprising 110 individuals (65 parents and 45 adolescents) consecutively recruited from primary care registries. Participants underwent anthropometric and biochemical evaluation, including indices of central body fat distribution. Linear mixed models were used to investigate associations between parental characteristics and adolescent BMI percentile while accounting for non-independence of observations within families. Results: Mean parental BMI was 31.37 +/- 5.67 kg/m(2), while 61.5% of parents had obesity. Among adolescents, 28.9% had BMI percentile between the 85th and 95th percentiles and 13.3% had a BMI percentile > 95th percentile. Strong family-level clustering of adolescent weight status was consistently observed across analyses, with intraclass correlation coefficients ranging from 0.716 to 0.728. In contrast, parental characteristics demonstrated limited explanatory contribution (marginal R(2) 0.028-0.044), while no isolated parental variable showed a significant association with adolescent BMI percentile. Conclusions: Strong family-level clustering of adolescent weight status was observed despite the absence of significant associations with individual parental anthropometric and metabolic characteristics, suggesting that familial obesity susceptibility may reflect shared influences extending beyond routinely measurable traits alone. FAU - Mournos, Vasilios AU - Mournos V AD - Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. FAU - Dimakopoulos, Georgios AU - Dimakopoulos G AUID- ORCID: 0000-0002-2351-7411 AD - BIOSTATS, Epirus Science and Technology Park Campus, University of Ioannina, 45110 Ioannina, Greece. FAU - Makridou, Theano AU - Makridou T AD - General Hospital of Veria, 59132 Veria, Greece. FAU - Kontotasios, Konstantinos AU - Kontotasios K AD - General Hospital of Veria, 59132 Veria, Greece. FAU - Pournaras, Dimitri J AU - Pournaras DJ AD - North Bristol NHS Trust, Bristol BS10 5NB, UK. AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 1UD, UK. FAU - le Roux, Carel W AU - le Roux CW AUID- ORCID: 0000-0001-5521-5445 AD - School of Medicine, University College Dublin, DO4 V1W8 Dublin, Ireland. FAU - Kokkinos, Alexander AU - Kokkinos A AD - First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, 11527 Athens, Greece. FAU - Kotsa, Kalliopi AU - Kotsa K AUID- ORCID: 0000-0003-2376-740X AD - Division of Endocrinology and Metabolism and Diabetes Center, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, 54636 Thessaloniki, Greece. FAU - Koufakis, Theocharis AU - Koufakis T AUID- ORCID: 0000-0002-5853-1352 AD - Second Propaedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration General Hospital, 49 Konstantinoupoleos Str., 54642 Thessaloniki, Greece. LA - eng PT - Journal Article DEP - 20260724 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13466985 OTO - NOTNLM OT - adolescent obesity OT - anthropometric characteristics OT - body mass index OT - family clustering COIS- DJP declares consulting fees from Johnson & Johnson, Novo Nordisk, Eli Lilly, Pfizer, GSK and Medtronic as well as honoraria from Johnson & Johnson, Medtronic, Sandoz and Novo Nordisk. ClR reports grants from the EU Innovative Medicine Initiative, Irish Research Council, Science Foundation Ireland, Anabio, and the Health Research Board. He serves on advisory boards and speakers panels of Abbvie, Altimmune, Amgen, Arrowhead Pharma, Astrazeneca, Boehringer Ingelheim, Eli Lily, Gila Pharmaceuticals, Herbalife, Irish Life Health, Johnson and Johnson, Keyron, Medscape, Metsera, Morphic Medical, Novo Nordisk, Nymble, Olympus, Pfizer, Rhythm Pharma, Roche, Wave, and Zealand Pharma. ClR is the Chair of the Irish Society for Nutrition and Metabolism. ClR received stock options as payment for scientific advisory board functions from Nymble. ClR provides obesity clinical care at the My Best Weight clinic and Beyond BMI clinic and is a co-owner of these clinics. AK reports research grants through his institution by Novo Nordisk Greece, Pharmaserve Lilly Greece, and ELPEN Pharma Greece. AK is on the speakers' bureau for Novo Nordisk Greece, Pharmaserve Lilly Greece, Astra Zeneca Greece, MSD Greece, Sanofi Greece, Bausch Health Greece, Ethicon Greece, Galenica Pharma Greece, Epsilon Health Greece, Winmedica Greece, and Viatris, and has consulting agreements with Novo Nordisk Greece, Pharmaserve Lilly Greece, Sanofi Greece, and Boehringer Ingelheim. TK has received honoraria for lectures from AstraZeneca, Sanofi, Boehringer Ingelheim, Pharmaserve Lilly, ELPEN, Menarini, and Novo Nordisk, for serving on advisory boards from Novo Nordisk, Roche Diagnostics, Sanofi, and Boehringer Ingelheim and has participated in sponsored studies by Eli-Lilly, AstraZeneca, and Novo Nordisk. The other authors declare that no conflicts of interest or financial relationships relevant to this article exist. EDAT- 2026/08/13 05:35 MHDA- 2026/08/13 05:36 PMCR- 2026/07/24 CRDT- 2026/08/13 01:05 PHST- 2026/06/17 00:00 [received] PHST- 2026/07/14 00:00 [revised] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/08/13 05:36 [medline] PHST- 2026/08/13 05:35 [pubmed] PHST- 2026/08/13 01:05 [entrez] PHST- 2026/07/24 00:00 [pmc-release] AID - jcm15155790 [pii] AID - jcm-15-05790 [pii] AID - 10.3390/jcm15155790 [doi] PST - epublish SO - J Clin Med. 2026 Jul 24;15(15):5790. doi: 10.3390/jcm15155790. PMID- 42588200 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260827 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 15 DP - 2026 Aug 6 TI - Is Phenylalanine Restricted Dietary Treatment in Phenylketonuria Associated with Disordered Eating: A Systematic Review. LID - 10.3390/nu18152576 [doi] LID - 2576 AB - Background: In phenylketonuria (PKU), the lifelong phenylalanine (Phe)-restricted diet may contribute to altered feeding behaviours and disordered eating. The true prevalence of disordered eating and eating disorders remains uncertain, partly because validated PKU-specific assessment tools are lacking. This systematic review aimed to identify, appraise, and synthesise the evidence on disordered eating and eating disorders in PKU. Methods: Four electronic databases (PubMed, Scopus, Web of Science, and Cochrane) were searched from inception to 24 February 2026. English-language studies reporting disordered eating or eating disorders in early-diagnosed individuals with PKU managed with a Phe-restricted diet, with or without drug therapy, were included. Studies of late- or never-treated patients, pregnancy, lactation, reviews, and preclinical studies were excluded. Two independent reviewers conducted study selection and data extraction. Outcomes included the prevalence of eating disorders, disordered eating behaviours and attitudes, associated factors, and the influence of drug treatment. Findings were synthesised qualitatively, and risk of bias was assessed using the NIH Study Quality Assessment Tools. Results: Twenty-four studies (2928 individuals with PKU) met the inclusion criteria. Most were observational or survey-based. Eating disorders were reported more frequently in PKU (3-13%) than in the general population (n = 4 studies). Common disordered eating features included food neophobia (n = 5 studies), limited food variety (n = 9), food aversion or refusal (n = 5), poor appetite (n = 5), prolonged mealtimes (n = 3), negative parent-child mealtime interactions (n = 6), and specific taste preferences (n = 5). Delayed feeding skill development (n = 6 studies), reduced social eating (n = 6), gastrointestinal symptoms (n = 8), and psychological or neurodevelopmental difficulties (n = 7) were also associated with disordered eating. Early feeding difficulties frequently persisted into adulthood, and longstanding eating behaviours did not consistently improve with pharmaceutical treatment (n = 6 studies). Most studies were rated as fair quality (19/24), with common limitations including small sample sizes, lack of sample-size justification, non-validated assessment tools, and absence of randomised controlled trials. Conclusions: Current evidence suggests that people with PKU experience a greater burden of eating-related difficulties than the general population, although robust estimates of eating disorder prevalence remain lacking. Existing screening tools may misclassify treatment-related dietary behaviours as pathological or fail to identify PKU-specific eating concerns. Development of PKU-specific screening tools could support routine clinical discussions about eating behaviours and the psychosocial impact of dietary treatment, facilitating earlier identification of individuals requiring specialist eating disorder assessment. (Prospero registration: CRD42024539600). FAU - Evans, Sharon AU - Evans S AUID- ORCID: 0000-0002-7654-3621 AD - Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK. FAU - Ilgaz, Fatma AU - Ilgaz F AUID- ORCID: 0000-0002-6518-0255 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Ankara 06100, Turkey. FAU - MacDonald, Anita AU - MacDonald A AD - Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK. LA - eng GR - Nutricia (United Kingdom)/ PT - Journal Article PT - Systematic Review DEP - 20260806 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 47E5O17Y3R (Phenylalanine) SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - *Feeding and Eating Disorders/epidemiology/etiology/diet therapy MH - Feeding Behavior MH - *Phenylalanine/blood MH - *Phenylketonurias/diet therapy/complications/psychology MH - Prevalence MH - Diet, Protein-Restricted PMC - PMC13467740 OTO - NOTNLM OT - PKU OT - disordered eating OT - eating disorders OT - phenylketonuria COIS- The funders had no role in the design of the study; in the collection, analyses or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. S.E. receives research funding from Vitaflo. F.I. declares no conflicts of interest in relation to this project. A.M. has received research or advisory board funding from Ajinomoto Cambrooke, Applied Pharma Research, Arla Food Ingredients, BioMarin Pharmaceutical, Galen Pharma, Ipsen Pharma, Jnana Therapeutics, MetaHealth, metaX, Nutricia, PIAM, PTC Therapeutics, and Vitaflo International. EDAT- 2026/08/13 05:35 MHDA- 2026/08/13 05:36 PMCR- 2026/08/06 CRDT- 2026/08/13 01:02 PHST- 2026/06/22 00:00 [received] PHST- 2026/07/26 00:00 [revised] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/08/13 05:36 [medline] PHST- 2026/08/13 05:35 [pubmed] PHST- 2026/08/13 01:02 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - nu18152576 [pii] AID - nutrients-18-02576 [pii] AID - 10.3390/nu18152576 [doi] PST - epublish SO - Nutrients. 2026 Aug 6;18(15):2576. doi: 10.3390/nu18152576. PMID- 42588145 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260815 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 15 DP - 2026 Aug 4 TI - Sex-Specific Associations Between MTHFR, PPARG and ADRB3 Polymorphisms, Habitual Nutrient Intake and Metabolic Risk in Obesity: A Cross-Sectional Single-Centre Study. LID - 10.3390/nu18152522 [doi] LID - 2522 AB - Background/Objectives: Genetic polymorphisms modulate the risk of metabolic complications of obesity; yet, it remains unclear how genotype reshapes actual dietary intake and why these mechanisms differ between men and women. The aim of this study was to identify sex-specific associations of three common polymorphisms (MTHFR C677T, PPARG Pro12Ala, ADRB3 Trp64Arg) with habitual nutrient intake in patients with obesity, and to explore candidate sex-differentiated dietary hypotheses for future prospective testing. Methods: A single-centre cross-sectional study was performed in 348 patients with obesity (83 men, 265 women; BMI >/= 30 kg/m(2); age 18-60 years). Genotyping was performed by allele-specific real-time PCR from buccal swabs. Habitual intake of more than 18 nutrients was assessed using a standardised Russian software-based questionnaire. Statistical analysis included Kruskal-Wallis and Mann-Whitney tests with Bonferroni correction (threshold p < 0.017), as well as odds ratios (OR) with 95% confidence intervals. Genotype distributions were tested for Hardy-Weinberg equilibrium, and genotype-nutrient associations were additionally examined in models adjusted for age, BMI and total energy intake. Results: Three genotype-phenotype associations remained significant after Bonferroni correction. In men, the dominant-heterozygous MTHFR C/T genotype was associated with a hypercaloric dietary pattern-excess protein, fat, sodium and phosphorus-and with a high risk of arterial hypertension (OR 5.96, 95% CI 1.48-24.08; p = 0.010). The sodium load in C/T carriers was a consequence of overall overeating rather than a selective preference for salty foods. In men, ADRB3 Trp64Arg carriage was associated with massive dietary cholesterol overconsumption (+466% vs. +153% in Trp/Trp; p = 0.012), whereas in women the opposite direction was observed. The PPARG G/G genotype in women was associated with elevated alanine aminotransferase (p = 0.027), most pronounced under 40 years (p = 0.011), and is considered a marker of hepatic risk without a confirmed dietary target. In women, the MTHFR T/T homozygous genotype showed suggestive associations with excessive mono-/disaccharide intake and a tendency toward hypertension (OR 2.62, 95% CI 1.07-6.43; p = 0.035); however, these did not survive FDR correction and require independent validation. Conclusions: Genetic polymorphisms were associated with sex-specific patterns of actual dietary intake, a finding that extends current knowledge beyond biochemical risk associations. Based on these associations, we propose testable hypotheses rather than clinical recommendations: that caloric restriction (with consequent sodium reduction) in men with MTHFR C/T, cholesterol restriction in men with ADRB3 Arg64, and mono-/disaccharide restriction in women with MTHFR T/T might reduce metabolic risk; women with PPARG G/G may warrant ALT monitoring. These findings suggest that genotype-informed dietary strategies may need to be sex-specific, and that the window for intervention may be earlier in life than currently practised. However, these hypotheses require prospective interventional validation before any clinical application. FAU - Lapik, Irina A AU - Lapik IA AUID- ORCID: 0000-0002-0963-0792 AD - Federal Research Centre of Nutrition, Biotechnology and Food Safety, 2/14 Ustinsky Proyezd, Moscow 109240, Russia. FAU - Tarmaeva, Inna Yu AU - Tarmaeva IY AUID- ORCID: 0000-0001-7791-1222 AD - Federal Research Centre of Nutrition, Biotechnology and Food Safety, 2/14 Ustinsky Proyezd, Moscow 109240, Russia. FAU - Nikityuk, Dmitry B AU - Nikityuk DB AUID- ORCID: 0000-0002-4968-4517 AD - Federal Research Centre of Nutrition, Biotechnology and Food Safety, 2/14 Ustinsky Proyezd, Moscow 109240, Russia. AD - I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation, Moscow 119991, Russia. LA - eng GR - FGMF-2026-0014/Federal Research Centre of Nutrition and Biotechnology/ PT - Journal Article DEP - 20260804 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (PPAR gamma) RN - 0 (Receptors, Adrenergic, beta-3) RN - 0 (ADRB3 protein, human) RN - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2)) RN - EC 1.5.1.20 (MTHFR protein, human) SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Cross-Sectional Studies MH - Middle Aged MH - *PPAR gamma/genetics MH - *Obesity/genetics MH - *Receptors, Adrenergic, beta-3/genetics MH - Adolescent MH - *Methylenetetrahydrofolate Reductase (NADPH2)/genetics MH - Young Adult MH - Sex Factors MH - *Feeding Behavior MH - Genotype MH - *Polymorphism, Genetic MH - Genetic Predisposition to Disease MH - Risk Factors MH - Diet MH - Genetic Association Studies PMC - PMC13468027 OTO - NOTNLM OT - ADRB3 Trp64Arg OT - MTHFR C677T OT - PPARG Pro12Ala OT - arterial hypertension OT - habitual dietary intake OT - metabolic dysfunction-associated steatotic liver disease OT - nutrigenetics OT - obesity OT - personalised prevention OT - sex differences COIS- The authors declare no conflicts of interest. EDAT- 2026/08/13 05:35 MHDA- 2026/08/13 05:36 PMCR- 2026/08/04 CRDT- 2026/08/13 01:02 PHST- 2026/07/10 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/08/13 05:36 [medline] PHST- 2026/08/13 05:35 [pubmed] PHST- 2026/08/13 01:02 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - nu18152522 [pii] AID - nutrients-18-02522 [pii] AID - 10.3390/nu18152522 [doi] PST - epublish SO - Nutrients. 2026 Aug 4;18(15):2522. doi: 10.3390/nu18152522. PMID- 42588098 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260815 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 15 DP - 2026 Jul 30 TI - Effects of Three Consecutive Days of Diurnal Intermittent Fasting on Cognitive Function, Psychomotor Vigilance, and Sleep Quality in Adolescent Male Soccer Players: A Quasi-Experimental Parallel-Group Study. LID - 10.3390/nu18152475 [doi] LID - 2475 AB - Aim: While voluntary Islamic intermittent fasting (IF) of three consecutive days (mimicking practices such as Ayyam al-Bid) may be observed by Muslim athletes, its short-term effects on cognitive function and sleep quality in adolescent team-sport athletes remain unexamined. This study investigated the impact of three successive days of dawn-to-sunset IF on memory, attention, psychomotor vigilance, and subjective sleep quality in young male soccer players. Methods: A quasi-experimental, parallel-group design was employed. Thirty-five male soccer players (age: 15.6 +/- 0.8 years; body mass: 55.07 +/- 6.53 kg) were allocated to an IF group (n = 17) or a non-fasting control group (n = 18). The fasting protocol comprised approximately 14 consecutive hours of complete food and fluid abstinence per day (from 04:40 to 18:36, with daily variations of -3 min for the dawn and +2 min for the sunset, local time). Cognitive function was assessed using the CogniFit Cognitive Assessment Battery (CAB) and the Psychomotor Vigilance Test (PVT), and subjective well-being was quantified via the Hooper Index. Both assessment sessions were conducted between 14:00 and 17:00 to control for diurnal variation. Results: The Group x Time interaction for single-item subjective sleep quality reached nominal significance at the unadjusted threshold (Z = 2.18, p = 0.029, r = 0.37) but did not survive Bonferroni correction for the four Hooper Index comparisons (alpha = 0.0125); this result is therefore interpreted as hypothesis-generating only, reflecting a within-group deterioration in the control group (p < 0.05) alongside a non-significant marginal improvement in the fasting group. No statistically significant Group x Time interaction was detected for any memory subdomain (all p >/= 0.419, r 0.176, r 0.192, eta(2)p/r .073). Results support equivalence and feasibility of the remote APS for school-aged children with and without developmental differences. Recommendations for administration are discussed. FAU - Gordon, Rachel A AU - Gordon RA AUID- ORCID: 0000-0001-7566-6868 AD - Case Western Reserve University, Cleveland, OH. FAU - Doernberg, Ellen A AU - Doernberg EA AD - Boston Children's Hospital, Boston, MA. FAU - Dimitropoulos, Anastasia AU - Dimitropoulos A AD - Case Western Reserve University, Cleveland, OH. FAU - Russ, Sandra W AU - Russ SW AD - Case Western Reserve University, Cleveland, OH. LA - eng PT - Journal Article DEP - 20260225 PL - United States TA - Am J Intellect Dev Disabil JT - American journal on intellectual and developmental disabilities JID - 101492916 SB - IM MH - Humans MH - Child MH - Female MH - *Play and Playthings MH - *Autism Spectrum Disorder/diagnosis/physiopathology MH - Male MH - *Prader-Willi Syndrome/diagnosis/physiopathology MH - Telemedicine MH - *Affect/physiology MH - *Psychometrics/instrumentation OTO - NOTNLM OT - Affect in Play Scale OT - Prader-Willi Syndrome OT - Pretend play OT - assessment OT - autism spectrum disorder OT - telehealth EDAT- 2026/08/12 17:35 MHDA- 2026/08/12 17:36 CRDT- 2026/08/12 11:25 PHST- 2026/08/12 17:36 [medline] PHST- 2026/08/12 17:35 [pubmed] PHST- 2026/08/12 11:25 [entrez] AID - 10.1080/19447558.2026.2615614 [doi] PST - ppublish SO - Am J Intellect Dev Disabil. 2026;131(3):204-211. doi: 10.1080/19447558.2026.2615614. Epub 2026 Feb 25. PMID- 42583817 OWN - NLM STAT- MEDLINE DCOM- 20260812 LR - 20260909 IS - 2054-1058 (Electronic) IS - 2054-1058 (Linking) VI - 13 IP - 8 DP - 2026 Aug TI - Prevalence of Kinesiophobia and Associated Factors Among Patients After Percutaneous Coronary Intervention: A Multicenter Cross-Sectional Study. PG - e70748 LID - 10.1002/nop2.70748 [doi] LID - e70748 AB - AIM: To investigate the prevalence and associated factors of kinesiophobia after percutaneous coronary intervention (PCI). DESIGN: A multicenter cross-sectional study. METHODS: We collected data of post-PCI patients who were recruited via convenience sampling from cardiology departments of eight tertiary hospitals between 1 November 2022 and 31 December 2023. Kinesiophobia was assessed by the Tampa Scale for Kinesiophobia Heart (TSK-SV Heart). Exercise self-efficacy, depression, anxiety, stress, and social support were evaluated by validated instruments. Participants' demographic and objective socioeconomic factors were also collected. Binary logistic regression analysis was conducted to identify the associated factors of kinesiophobia. RESULTS: Of 1145 recruited patients, 970 (84.72%) provided complete data and were included in the final analysis, of which 780 (80.41%) exhibited kinesiophobia. Factors significantly associated with kinesiophobia in the binary logistic regression analysis included: single status (vs. married: OR = 0.42, 95% CI: 0.22-0.79, p = 0.008), retired (vs. freelancers: OR = 1.89, 95% CI: 1.22-2.93, p = 0.004), had beyond 3 children (vs. 1 child: OR = 0.68, 95% CI: 0.46-0.99, p = 0.045), generally familiar with illness (vs. not familiar: OR = 2.00, 95% CI: 1.37-2.93, p < 0.001), comorbid hypertension (vs. no hypertension: OR = 1.49, 95% CI: 1.05-2.13, p = 0.028), participated in cardiac rehabilitation (vs. did not participate: OR = 1.52, 95% CI: 1.06-2.19, p = 0.023), moderate physical activity (vs. low: OR = 0.64, 95% CI: 0.42-0.97, p = 0.034), and high physical activity (vs. low: OR = 0.40, 95% CI: 0.25-0.65, p < 0.001) were significantly associated with kinesiophobia occurrence (p < 0.05). For each one-point increase in stress, anxiety, and objective support, the odds of kinesiophobia increased by 9% (OR = 1.09, 95% CI: 1.02-1.15, p = 0.008), 21% (OR = 1.21, 95% CI: 1.12-1.29, p < 0.001), and 9% (OR = 1.09, 95% CI: 1.01-1.19, p = 0.027), respectively. For each one-point increase in depression and SEE-C score, the odds of kinesiophobia decreased by 11% (OR = 0.89, 95% CI: 0.84-0.96, p = 0.001) and 1% (OR = 0.99, 95% CI: 0.98-0.99, p < 0.001), respectively. CONCLUSION: Kinesiophobia is highly prevalent among post-PCI patients. Identified associated factors include marital status, occupational status, number of children, illness familiarity, hypertension comorbidity, cardiac rehabilitation participation, physical activity level, levels of psychological distress, objective support, and exercise self-efficacy. These findings highlight potential targets for intervention. IMPLICATIONS FOR THE PROFESSION AND PATIENT CARE: Nurses should integrate routine kinesiophobia screening using the TSK-SV Heart scale into post-PCI assessment protocols. Risk-stratified screening should prioritize married or retired patients, those with fewer than three children, individuals with hypertension, and those with low baseline physical activity. For patients with low exercise self-efficacy, nurses can use motivational interviewing; for those with elevated anxiety or stress, collaborative cognitive-behavioural therapy is recommended. These nursing actions can reduce kinesiophobia and improve cardiac rehabilitation adherence. IMPACT: What problem did the study address? Kinesiophobia is a common but under-recognized barrier to cardiac rehabilitation in post-PCI patients, yet its prevalence and modifiable factors in Chinese populations remain poorly understood. What were the main findings? The prevalence of kinesiophobia was 80.41%. Independent associated factors included marital status, retirement, number of children, illness familiarity, hypertension, cardiac rehabilitation participation, physical activity level, anxiety, stress, depression, objective support, and exercise self-efficacy. Where and on whom will the research have an impact? The findings directly inform cardiac nursing practice in China and similar settings, enabling nurses to identify high-risk patients and implement targeted psychosocial interventions. REPORTING METHOD: This study adhered to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guideline for cross-sectional observational studies. PATIENT OR PUBLIC CONTRIBUTION: No patient or public contributed to the design, conduct, analysis, or interpretation of this study. TRIAL REGISTRATION: This observational study was registered in the Chinese Clinical Trial Registry (No. ChiCTR2300070396; https://www.chictr.org.cn/). CI - (c) 2026 The Author(s). Nursing Open published by John Wiley & Sons Ltd. FAU - Wang, Chunyuan AU - Wang C AD - Interventional Operation Center, Guangzhou First People's Hospital, Guangzhou, China. FAU - Hou, Xiaoqin AU - Hou X AD - Interventional Operation Center, Guangzhou First People's Hospital, Guangzhou, China. FAU - Zhang, Pian AU - Zhang P AD - Interventional Operation Center, Guangzhou First People's Hospital, Guangzhou, China. FAU - Liu, Caiyang AU - Liu C AD - Interventional Operation Center, Guangzhou First People's Hospital, Guangzhou, China. FAU - Yang, Yi AU - Yang Y AUID- ORCID: 0009-0000-2994-8346 AD - Department of Cardiology, Guangdong Provincial People's Hospital, Guangzhou, China. FAU - Zhao, Zhenhua AU - Zhao Z AD - Department of Cardiology, Guangdong Second Provincial People's Hospital, Guangzhou, China. FAU - Jiang, Weijun AU - Jiang W AD - Interventional Operating Room, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. FAU - Su, Guanfu AU - Su G AD - Department of Cardiology, Huizhou Central People's Hospital, Huizhou, China. FAU - Jiang, Xiaofang AU - Jiang X AUID- ORCID: 0009-0003-6556-3226 AD - Department of Cardiology, Northern Guangdong People's Hospital, Shaoguan, China. FAU - Lin, Lijuan AU - Lin L AD - Department of Cardiology, Meizhou People's Hospital, Meizhou, China. FAU - Ning, Libing AU - Ning L AD - Department of Cardiology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China. FAU - Lin, Lixia AU - Lin L AD - Department of Cardiology, Guangdong Provincial People's Hospital, Guangzhou, China. FAU - Zhan, Lechang AU - Zhan L AD - Department of Rehabilitation, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Zhan, Jie AU - Zhan J AUID- ORCID: 0000-0003-0220-3699 AD - Department of Rehabilitation, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. LA - eng GR - 2023HL11/the Hongmian project of GuangZhou First People's Hospital/ PT - Journal Article PT - Multicenter Study PT - Observational Study PL - United States TA - Nurs Open JT - Nursing open JID - 101675107 SB - IM MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Anxiety/psychology MH - Cross-Sectional Studies MH - *Kinesiophobia/epidemiology MH - *Percutaneous Coronary Intervention/psychology/adverse effects MH - Prevalence MH - Risk Factors MH - Surveys and Questionnaires PMC - PMC13463317 OTO - NOTNLM OT - exercise adherence OT - kinesiophobia OT - nursing assessment OT - percutaneous coronary intervention OT - psychological assessment OT - rehabilitation nursing COIS- Statistical Declaration Statement: The authors confirm that all statistical analyses in this study were performed appropriately. Data analysis was conducted using SPSSAU (version 26.0, https://www.spssau.com). The choice of statistical methods was guided by the nature of the data and the study objectives. Normality of continuous variables was assessed using the Shapiro-Wilk test, leading to the use of Mann-Whitney U test and Spearman correlation where appropriate. Categorical variables were analysed using the chi-square test. Binary logistic regression with stepwise selection was used to identify independent predictors of kinesiophobia, with results reported as odds ratios (ORs) and 95% confidence intervals (CIs). Multicollinearity was assessed using the variance inflation factor (VIF) and tolerance. Tolerance values > 0.1 (or VIF < 10) indicated no significant multicollinearity. Model fit was evaluated using the Hosmer-Lemeshow goodness-of-fit test. A non-significant p value (> 0.05) indicated adequate model fit. The overall model significance was tested using the likelihood ratio test comparing the final model to the null model. A two-sided p < 0.05 was considered statistically significant. AI Tools Acknowledgement: No generative artificial intelligence tools were used in the preparation of this manuscript. All writing, analysis, and interpretation were performed by the authors. The authors declare no conflicts of interest. EDAT- 2026/08/12 11:37 MHDA- 2026/08/12 11:38 PMCR- 2026/08/12 CRDT- 2026/08/12 07:32 PHST- 2026/07/30 00:00 [revised] PHST- 2024/12/24 00:00 [received] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/08/12 11:38 [medline] PHST- 2026/08/12 11:37 [pubmed] PHST- 2026/08/12 07:32 [entrez] PHST- 2026/08/12 00:00 [pmc-release] AID - NOP270748 [pii] AID - 10.1002/nop2.70748 [doi] PST - ppublish SO - Nurs Open. 2026 Aug;13(8):e70748. doi: 10.1002/nop2.70748. PMID- 42582380 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260812 LR - 20260813 IS - 2673-3153 (Electronic) IS - 2673-3153 (Print) IS - 2673-3153 (Linking) VI - 8 DP - 2026 TI - Development and temporal validation of a prediction model for live birth in infertile women with polyendocrine metabolic ovarian syndrome: a retrospective cohort study. PG - 1891181 LID - 10.3389/frph.2026.1891181 [doi] LID - 1891181 AB - OBJECTIVE: To develop and temporally validate a prediction model for delivery of a live-born infant within 365 days after the initial infertility consultation in infertile women with a documented diagnosis of polycystic ovary syndrome (PCOS), which was renamed in 2026 as polyendocrine metabolic ovarian syndrome (PMOS), using routine clinical and basal endocrine variables. METHODS: This single-center retrospective cohort study included infertile women with a documented diagnosis of PCOS and an index date between December 1, 2021, and December 31, 2024. The index date was the first infertility consultation at which baseline clinical assessment and basal endocrine testing were completed. Patients were assigned to the development cohort (December 1, 2021-December 31, 2023) or the same-center temporal validation cohort (January 1-December 31, 2024). Outcome ascertainment ended on December 31, 2025. Multivariable logistic regression was used to predict delivery of a live-born infant within 365 days under routine individualized care. RESULTS: Among 610 women, 389 were in the development cohort and 221 in the temporal validation cohort. Live-birth proportions within 365 days were 44.7% and 44.3%, respectively. Complete-case model development and validation included 349 and 203 women, respectively. The final model included age, body mass index, infertility duration, gravidity, luteinizing hormone/follicle-stimulating hormone ratio, tubal/pelvic factors, and uterine factors. Older age (OR = 0.91, 95% CI: 0.85-0.98), higher body mass index (OR = 0.92, 95% CI: 0.86-0.98), longer infertility duration (OR = 0.85, 95% CI: 0.77-0.94), higher luteinizing hormone/follicle-stimulating hormone ratio (OR = 0.71, 95% CI: 0.55-0.91), and uterine factors (OR = 0.37, 95% CI: 0.15-0.80) were associated with lower live-birth probability. The AUCs were 0.735 and 0.738, and the Brier scores were 0.208 and 0.205, respectively. CONCLUSION: This model showed moderate discrimination and acceptable calibration for predicting delivery of a live-born infant within 365 days after initial infertility consultation. Multicenter external validation and impact studies are needed before broader clinical application. CI - (c) 2026 Liu, Wang, Lu, Jia, Geng, Cao, Han and Zhou. FAU - Liu, Peng AU - Liu P AD - Department of Clinical Laboratory, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China. FAU - Wang, Shuhong AU - Wang S AD - Department of Clinical Laboratory, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China. FAU - Lu, Yubo AU - Lu Y AD - School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, China. FAU - Jia, Hanbing AU - Jia H AD - Department of Clinical Laboratory, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China. FAU - Geng, Yue AU - Geng Y AD - Department of Clinical Laboratory, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China. FAU - Cao, Cuijuan AU - Cao C AD - Department of Clinical Laboratory, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China. FAU - Han, Le AU - Han L AD - Department of Clinical Laboratory, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China. FAU - Zhou, Yingjie AU - Zhou Y AD - Department of Clinical Laboratory, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China. LA - eng PT - Journal Article DEP - 20260728 PL - Switzerland TA - Front Reprod Health JT - Frontiers in reproductive health JID - 9918230899006676 PMC - PMC13457464 OTO - NOTNLM OT - infertility OT - live birth OT - nomogram OT - polycystic ovary syndrome OT - polyendocrine metabolic ovarian syndrome OT - prediction model OT - temporal validation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/12 11:38 MHDA- 2026/08/12 11:39 PMCR- 2026/07/28 CRDT- 2026/08/12 06:04 PHST- 2026/05/26 00:00 [received] PHST- 2026/07/09 00:00 [revised] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/08/12 11:39 [medline] PHST- 2026/08/12 11:38 [pubmed] PHST- 2026/08/12 06:04 [entrez] PHST- 2026/07/28 00:00 [pmc-release] AID - 10.3389/frph.2026.1891181 [doi] PST - epublish SO - Front Reprod Health. 2026 Jul 28;8:1891181. doi: 10.3389/frph.2026.1891181. eCollection 2026. PMID- 42581838 OWN - NLM STAT- MEDLINE DCOM- 20260812 LR - 20260909 IS - 1478-5153 (Electronic) IS - 1362-1017 (Print) IS - 1362-1017 (Linking) VI - 31 IP - 5 DP - 2026 Sep TI - Sleep Characteristics of Parents of Children in the Paediatric Intensive Care Unit: A Pilot Observational Study. PG - e70609 LID - 10.1111/nicc.70609 [doi] LID - e70609 AB - BACKGROUND: Parents of children hospitalised in the paediatric intensive care unit (PICU) exhibit poor sleep quality due to stress from the child's illness, uncertainty and changing family roles. AIMS: We aimed to utilise two subjective and one objective measurement to examine sleep characteristics among parents of children in the PICU and explore possible contributing factors, including parental stress. STUDY DESIGN: This observational pilot study assessed parents of children in the PICU in South Korea using the Pittsburgh Sleep Quality Index (PSQI) and the General Sleep Disturbance Scale (GSDS). Sleep-related parameters were measured for 3 nights using an actigraph. The Parental Stress Scale:PICU was used to assess stress levels. RESULTS: A total of 18 parents participated in the study. Sleep quality was poor on both PSQI and GSDS, and their total sleep scores did not correlate with any actigraphy parameter. Only the GSDS daytime function subscale suggested associations with sleep efficiency (p = 0.04) and wake after sleep onset (p = 0.04). Parents averaged 5.73 h of sleep per night, with a sleep efficiency of 86.8%. The most prominent stressors were changes in parental roles and the child's appearance, while stress levels were not significantly related to sleep. No single factor influenced sleep across all tools; rather, different factors, including parent characteristics and length of stay, exerted an influence that varied by measurement tool. All participants completed the actigraphy protocol, proving its feasibility. CONCLUSIONS: Factors influencing parental sleep varied by measurement tool, suggesting that subjective and objective sleep measures may capture different aspects of sleep in parents. As this was a pilot study for hypothesis generation and feasibility, the findings require further validation in larger-scale studies. RELEVANCE TO CLINICAL PRACTICE: A comprehensive assessment that integrates objective and subjective sleep measures could improve the understanding of sleep among PICU parents and inform effective support strategies. CI - (c) 2026 The Author(s). Nursing in Critical Care published by John Wiley & Sons Ltd on behalf of British Association of Critical Care Nurses. FAU - Lee, Hyejung AU - Lee H AUID- ORCID: 0000-0001-9357-0640 AD - Mo-Im Kim Nursing Research Institute, College of Nursing, Yonsei University, Seoul, South Korea. FAU - Lee, Hyeryeong AU - Lee H AUID- ORCID: 0000-0002-3043-6767 AD - College of Nursing, The Ohio State University, Columbus, Ohio, USA. AD - College of Nursing, Yonsei University, Seoul, South Korea. FAU - Jung, Sanghun AU - Jung S AD - Severance Hospital, Yonsei University Health System, Seoul, USA South Korea. FAU - Park, Ai Soon AU - Park AS AD - Severance Hospital, Yonsei University Health System, Seoul, USA South Korea. LA - eng GR - Yonsei University College of Nursing/ PT - Journal Article PT - Observational Study PL - England TA - Nurs Crit Care JT - Nursing in critical care JID - 9808649 SB - IM MH - Humans MH - Pilot Projects MH - *Intensive Care Units, Pediatric MH - Female MH - *Parents/psychology MH - Male MH - Child MH - Republic of Korea MH - *Sleep Quality MH - *Stress, Psychological MH - Child, Preschool MH - Actigraphy MH - *Sleep Wake Disorders MH - Adult MH - Sleep Duration MH - *Sleep/physiology MH - Infant PMC - PMC13463211 OTO - NOTNLM OT - hospitalised child OT - paediatric intensive care unit OT - parents OT - sleep quality COIS- The authors declare no conflicts of interest. EDAT- 2026/08/12 11:38 MHDA- 2026/08/12 11:39 PMCR- 2026/08/12 CRDT- 2026/08/12 05:05 PHST- 2026/06/22 00:00 [revised] PHST- 2026/04/11 00:00 [received] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/08/12 11:39 [medline] PHST- 2026/08/12 11:38 [pubmed] PHST- 2026/08/12 05:05 [entrez] PHST- 2026/08/12 00:00 [pmc-release] AID - NICC70609 [pii] AID - 10.1111/nicc.70609 [doi] PST - ppublish SO - Nurs Crit Care. 2026 Sep;31(5):e70609. doi: 10.1111/nicc.70609. PMID- 42579937 OWN - NLM STAT- Publisher LR - 20260811 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 91 DP - 2026 Aug 11 TI - The mediating role of impulsivity in the relationship between multiple screen addiction and nighttime eating behaviors among adolescents. PG - 100-108 LID - S0882-5963(26)00372-6 [pii] LID - 10.1016/j.pedn.2026.08.003 [doi] AB - OBJECTIVE: This study examined whether impulsivity mediates the association between multiple screen addiction and nighttime eating behaviors among adolescents. METHODS: A cross-sectional design was used with 1247 adolescents recruited through purposive venue-based sampling with socioeconomic stratification in eastern Turkey province. Multiple screen addiction, impulsivity, and nighttime eating behaviors were assessed using validated self-report scales. A latent-variable structural equation model was tested, with age, gender, sleep duration, BMI z-score, and perceived socioeconomic status as covariates. Mediation was tested using bootstrap resampling (5000 resamples). RESULTS: Multiple screen addiction was positively associated with both impulsivity (beta = 0.272) and nighttime eating behaviors. Impulsivity partially mediated the association, accounting for approximately 28% of the total association, while the direct association between multiple screen addiction and nighttime eating behaviors remained the dominant pathway (approximately 72%). The structural model demonstrated acceptable fit (CFI = 0.924, RMSEA = 0.063, SRMR = 0.058). CONCLUSION: Impulsivity represents one partial mechanism linking multiple screen addiction to nighttime eating behaviors in adolescents. Pediatric and school health nurses may benefit from incorporating assessment of multiple screen addiction and self-regulation into routine adolescent care. Findings should be interpreted within the regional context of a single eastern Turkey province. IMPLICATIONS FOR NURSING PRACTICE: Interventions targeting adolescent health should adopt a multidimensional approach that includes screen time management, promotion of healthy eating habits, and strengthening self-regulation skills. Early identification of at-risk adolescents and development of school- and community-based nursing interventions may help prevent maladaptive behavioral patterns. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Evcimen, Hasan AU - Evcimen H AD - Mus Alparslan University, Department of Therapy and Rehabilitation Mus, Turkey. Electronic address: hsn_evcimen@hotmail.com. FAU - Bilgin, Sonay AU - Bilgin S AD - Ataturk University, Faculty of Nursing, Department of Public Health Nursing, Erzurum, Turkey. LA - eng PT - Journal Article DEP - 20260811 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM OTO - NOTNLM OT - Adolescent OT - Impulsivity OT - Multiple screen addiction OT - Nighttime eating OT - Structural equation modeling COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/11 23:35 MHDA- 2026/08/11 23:35 CRDT- 2026/08/11 18:01 PHST- 2026/04/14 00:00 [received] PHST- 2026/08/02 00:00 [revised] PHST- 2026/08/02 00:00 [accepted] PHST- 2026/08/11 23:35 [medline] PHST- 2026/08/11 23:35 [pubmed] PHST- 2026/08/11 18:01 [entrez] AID - S0882-5963(26)00372-6 [pii] AID - 10.1016/j.pedn.2026.08.003 [doi] PST - aheadofprint SO - J Pediatr Nurs. 2026 Aug 11;91:100-108. doi: 10.1016/j.pedn.2026.08.003. PMID- 42579372 OWN - NLM STAT- MEDLINE DCOM- 20260811 LR - 20260817 IS - 1540-8175 (Electronic) IS - 0742-2822 (Print) IS - 0742-2822 (Linking) VI - 43 IP - 8 DP - 2026 Aug TI - Pretreatment Coronary Ultrasound Radiomics Combined With the Prognostic Nutritional Index for Predicting IVIG Resistance in Children With Kawasaki Disease. PG - e70559 LID - 10.1111/echo.70559 [doi] LID - e70559 AB - BACKGROUND: Intravenous immunoglobulin (IVIG) resistance in children with Kawasaki disease (KD) is associated with an increased risk of coronary artery injury and subsequent adverse cardiovascular outcomes. Early identification of patients at risk remains difficult in clinical practice. Conventional coronary ultrasound is largely based on geometric parameters, such as luminal diameter and Z scores, and may not fully capture local heterogeneity within coronary images. In this study, we investigated whether pretreatment coronary artery ultrasound radiomics could improve early identification of IVIG resistance in children with KD. We further developed a multimodal prediction model incorporating radiomics, the prognostic nutritional index (PNI), and clinical characteristics. METHODS: A total of 352 children diagnosed with KD and treated at The First Affiliated Hospital of Guangxi Medical University between January 2020 and January 2026 were retrospectively included. All patients received standardized treatment after diagnosis. Demographic characteristics, pretreatment laboratory results, conventional coronary ultrasound parameters, and two-dimensional static ultrasound images of the left coronary artery (LCA), left anterior descending artery (LAD), and right coronary artery (RCA) were collected. The pretreatment two-dimensional static coronary ultrasound images were imported into 3D Slicer for region-of-interest segmentation. A clinical prediction model was constructed using multivariable logistic regression. PNI was defined a priori as the primary nutritional-immunologic indicator. In addition, the potential incremental predictive value of other nutritional-inflammatory indices, including the C-reactive protein-to-albumin ratio (CAR), neutrophil-to-albumin ratio (NAR), neutrophil percentage-to-albumin ratio (NPAR), and C-reactive protein-albumin-lymphocyte (CALLY) index, was further evaluated. Radiomics features were selected through repeated segmentation, intraclass correlation coefficient (ICC)-based stability filtering, correlation filtering, and least absolute shrinkage and selection operator (LASSO) regression. The Clinic, Clinic + PNI, Radiomics, and Clinic + PNI + Radiomics models were assessed using receiver operating characteristic curves, DeLong tests, calibration curves, decision curve analysis, and Shapley Additive Explanations (SHAP) interpretation. The Kobayashi, Egami, and Sano scores were evaluated in the same training and validation cohorts. RESULTS: Among the 352 children, 57 (16.2%) were classified as IVIG resistant. Multivariable analysis showed that higher pretreatment maximum coronary artery Z score (Z(max)), longer fever duration, and higher neutrophil count were associated with an increased risk of IVIG resistance. In the validation cohort, the Clinic + PNI model showed favorable discriminatory ability, with an AUC of 0.855 (95% CI, 0.767-0.911), a sensitivity of 0.882, and a negative predictive value of 0.969. Seven radiomics features were selected and used to construct the radiomics score (Rad-score). In the training cohort, the Clinic + PNI + Radiomics model achieved higher AUC values than the Clinic, Clinic + PNI, and Radiomics models. This pattern was also observed in the validation cohort, where the integrated model achieved the highest AUC of 0.880 (95% CI, 0.817-0.944), although the between-model differences did not reach statistical significance. Decision curve analysis showed that the integrated model offered a favorable net benefit within clinically meaningful threshold ranges. SHAP analysis suggested that its predictions reflected the joint influence of systemic inflammatory burden, nutritional and immune status, and local imaging heterogeneity captured from coronary ultrasound images. The Kobayashi, Egami, and Sano scores yielded validation AUCs of 0.616, 0.567, and 0.449, respectively. CONCLUSIONS: Pretreatment coronary ultrasound radiomics may provide complementary information to conventional clinical, laboratory, and ultrasonographic parameters for assessing the risk of IVIG resistance in children with KD. By integrating inflammatory burden, nutritional-immunologic status, and local coronary imaging heterogeneity, the Clinic + PNI + Radiomics model showed favorable discrimination and potential clinical net benefit in internal validation. However, its incremental value and clinical applicability require further confirmation in external cohorts. CI - (c) 2026 Wiley Periodicals LLC. FAU - Xiao, Caiyi AU - Xiao C AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China. AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Chen, Chaorong AU - Chen C AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China. AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Huang, Yuanyuan AU - Huang Y AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China. AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Wei, Xianbin AU - Wei X AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Li, Bin AU - Li B AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Wu, Jing AU - Wu J AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Huang, Huiying AU - Huang H AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Su, Dunhui AU - Su D AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Zhang, Bulin AU - Zhang B AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Wu, Ji AU - Wu J AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China. LA - eng PT - Journal Article PL - United States TA - Echocardiography JT - Echocardiography (Mount Kisco, N.Y.) JID - 8511187 RN - 0 (Immunoglobulins, Intravenous) SB - IM MH - Humans MH - *Mucocutaneous Lymph Node Syndrome/drug therapy MH - Male MH - Female MH - Radiomics MH - Retrospective Studies MH - Prognosis MH - Child, Preschool MH - *Drug Resistance MH - *Immunoglobulins, Intravenous/therapeutic use MH - *Coronary Vessels/diagnostic imaging MH - *Nutrition Assessment MH - *Echocardiography/methods MH - Ultrasonography/methods MH - Infant PMC - PMC13460361 OTO - NOTNLM OT - IVIG resistance OT - Kawasaki disease OT - coronary artery ultrasound OT - prediction model OT - prognostic nutritional index OT - radiomics COIS- The authors declare no conflicts of interest. EDAT- 2026/08/11 17:36 MHDA- 2026/08/11 17:37 PMCR- 2026/08/11 CRDT- 2026/08/11 12:04 PHST- 2026/07/01 00:00 [revised] PHST- 2026/05/05 00:00 [received] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/08/11 17:37 [medline] PHST- 2026/08/11 17:36 [pubmed] PHST- 2026/08/11 12:04 [entrez] PHST- 2026/08/11 00:00 [pmc-release] AID - ECHO70559 [pii] AID - 10.1111/echo.70559 [doi] PST - ppublish SO - Echocardiography. 2026 Aug;43(8):e70559. doi: 10.1111/echo.70559. PMID- 42579007 OWN - NLM STAT- Publisher LR - 20260811 IS - 2366-0058 (Electronic) DP - 2026 Aug 11 TI - A simplified MRI‑based risk score and nomogram to predict initial objective response in unresectable hepatocellular carcinoma treated with HAIC, targeted therapy, and immunotherapy: a multicenter study. LID - 10.1007/s00261-026-05732-6 [doi] AB - PURPOSE: This study aimed to develop and validate a simplified risk score based on pretreatment Gd‑EOB‑DTPA MRI features for the noninvasive prediction of initial objective response rate (ORR) in patients with unresectable hepatocellular carcinoma (uHCC) undergoing triple therapy (hepatic arterial infusion chemotherapy [HAIC], tyrosine kinase inhibitors, and immune checkpoint inhibitors). METHODS: This retrospective study enrolled 223 uHCC patients from two medical centers who underwent Gd‑EOB‑DTPA‑enhanced MRI prior to initiating triple therapy (training set: n = 127; external test set: n = 96). Imaging features were evaluated and extracted. Independent predictors of initial ORR were identified by multivariate logistic regression to build a simplified imaging risk score (I-score), and a nomogram was constructed to visualize the final predictive model. Model performance was assessed by AUC, calibration (Hosmer‑Lemeshow test), confusion matrix, and decision curve analysis (DCA), with internal bootstrap and external validation. SHAP analysis provided interpretability. Patients were stratified into low‑ and high‑risk groups, and Kaplan‑Meier curves for progression‑free survival (PFS) and overall survival (OS) were compared. RESULTS: Three MRI features (irregular morphology, rim enhancement, peritumoral low signal) were independent negative predictors of initial ORR. The simplified I-score was formulated as: 1x(irregular morphology) + 1 x (rim enhancement) + 2 x (peritumoral low signal), with an optimal cut-off of 1.5. Following LASSO regression, BMI > 22.55, PA < 182.5 mg/L, NLR > 2.37, and I-score >/= 2 were included in the nomogram. The nomogram achieved AUCs of 0.890 in training and 0.841 in validation for ORR prediction, demonstrating good calibration (P > 0.05) and clinical benefit. SHAP analysis identified I-score as the most important contributor. The model significantly outperformed BCLC, ALBI, Child‑Pugh, and Six‑and‑Twelve staging systems (all P < 0.05). High‑risk patients had significantly worse PFS and OS than low‑risk patients. CONCLUSION: The MRI‑based simplified risk score and the derived nomogram offer a noninvasive and precise method for predicting initial ORR and classifying prognosis in uHCC patients undergoing triple therapy. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Wang, Yi-Kang AU - Wang YK AD - Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Feng, Hua-Guo AU - Feng HG AD - Chongqing Red Cross Hospital, Chongqing, China. FAU - Liu, Yan-Han AU - Liu YH AD - Chongqing University Jiangjin Hospital, Chongqing, China. FAU - Zhang, Chun-Yu AU - Zhang CY AD - Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Zhou, Xue AU - Zhou X AD - Chongqing University Jiangjin Hospital, Chongqing, China. FAU - Liu, Hai-Ling AU - Liu HL AD - Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. 980956941@qq.com. FAU - Liu, Zuo-Jin AU - Liu ZJ AD - Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. 300376@hospital.cqmu.edu.cn. FAU - Tan, Hao-Yang AU - Tan HY AUID- ORCID: 0000-0001-5739-378X AD - Chongqing University Jiangjin Hospital, Chongqing, China. 13609454209@163.com. LA - eng GR - 82504160/National Natural Science Foundation of China/ GR - 82370672/National Natural Science Foundation of China/ GR - BX20250259/China Postdoctoral Science Foundation/ GR - 2025YCXM010/Chongqing University Jiangjin Hospital Internal Cultivation Project/ PT - Journal Article DEP - 20260811 PL - United States TA - Abdom Radiol (NY) JT - Abdominal radiology (New York) JID - 101674571 SB - IM OTO - NOTNLM OT - Hepatic arterial infusion chemotherapy OT - Hepatocellular carcinoma OT - Imaging scores OT - Initial objective response OT - Magnetic resonance imaging COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/08/11 12:37 MHDA- 2026/08/11 12:37 CRDT- 2026/08/11 11:05 PHST- 2026/01/07 00:00 [received] PHST- 2026/08/02 00:00 [accepted] PHST- 2026/08/11 12:37 [medline] PHST- 2026/08/11 12:37 [pubmed] PHST- 2026/08/11 11:05 [entrez] AID - 10.1007/s00261-026-05732-6 [pii] AID - 10.1007/s00261-026-05732-6 [doi] PST - aheadofprint SO - Abdom Radiol (NY). 2026 Aug 11. doi: 10.1007/s00261-026-05732-6. PMID- 42578774 OWN - NLM STAT- MEDLINE DCOM- 20260811 LR - 20260811 IS - 2724-7031 (Electronic) IS - 0041-4131 (Linking) VI - 104 IP - 4 DP - 2026 May 1 TI - Chronic pain among patients treated for breast cancer: Prevalence and associates factors. PG - 678-682 LID - 10.62438/tunismed.v104i05.6520 [doi] AB - OBJECTIVES: Chronic pain has emerged as a significant health issue among women treated for breast cancer, representing a substantial burden that negatively affects quality of life. This study aimed to determine the prevalence and characteristics of chronic pain among Tunisian breast cancer survivors. METHODS: We conducted a cross-sectional descriptive and analytical study including 100 Tunisian women treated for breast cancer at the Medical Oncology Department of Fattouma Bourguiba University Hospital (Monastir, Tunisia). Data collected included sociodemographic and clinical characteristics, lifestyle habits, and medical history. Validated instruments were used, including the Brief Pain Inventory (BPI), Pain Catastrophizing Scale (PCS), DN4 questionnaire, Hospital Anxiety and Depression Scale (HADS), and Family APGAR score. RESULTS: The prevalence of chronic pain in our population was 100%. All participants reported persistent pain following breast cancer surgery, without any other identified medical cause. The most common pain locations were the breast and ipsilateral upper limb. Pain interference was generally mild in both affective and activity domains. Most participants (88%) belonged to highly functional families. Higher pain intensity was significantly associated with a greater number of children and a history of dysthyroidism. Multivariate analysis identified body mass index, number of children, and number of lymph nodes removed as independent predictors of pain intensity. Higher pain intensity was also associated with increased anxiety levels. CONCLUSIONS: Chronic pain is highly prevalent among breast cancer survivors and is influenced by multiple factors, highlighting the need for comprehensive assessment and management strategies. FAU - Khechine, Wiem AU - Khechine W AD - Department of Medical Oncology, Fattouma Bourguiba University Hospital, Monastir, Tunisia. FAU - Chouat, Marwa AU - Chouat M AD - Department of Medical Oncology, Fattouma Bourguiba University Hospital, Monastir, Tunisia. FAU - Hmad, Alaeddine AU - Hmad A AD - Department of Medical Oncology, Fattouma Bourguiba University Hospital, Monastir, Tunisia. FAU - Amamou, Badii AU - Amamou B AD - Department of Psychiatry, Fattouma Bourguiba University Hospital, Monastir, Tunisia. FAU - Felfoul, Asma AU - Felfoul A AD - Department of Medical Oncology, Fattouma Bourguiba University Hospital, Monastir, Tunisia. FAU - Korbi, Asma AU - Korbi A AD - Department of Gynecology and Obstetrics, Maternity and neonatology center, Monastir, Tunisia. FAU - Jebali, Fethi AU - Jebali F AD - Department of Anesthesiology, Maternity and neonatology center, Monastir, Tunisia. FAU - Zaied, Sonia AU - Zaied S AD - Department of Medical Oncology, Fattouma Bourguiba University Hospital, Monastir, Tunisia. FAU - Daldoul, Amira AU - Daldoul A AD - Department of Medical Oncology, Fattouma Bourguiba University Hospital, Monastir, Tunisia. LA - eng PT - Journal Article DEP - 20260501 PL - Tunisia TA - Tunis Med JT - La Tunisie medicale JID - 0413766 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - *Breast Neoplasms/complications/epidemiology/therapy/surgery MH - Prevalence MH - *Chronic Pain/epidemiology/etiology MH - Tunisia/epidemiology MH - Middle Aged MH - Adult MH - Quality of Life MH - Aged MH - Pain Measurement MH - Mastectomy/adverse effects MH - Cancer Survivors/statistics & numerical data MH - Surveys and Questionnaires MH - Risk Factors OTO - NOTNLM OT - Breast cancer survivors OT - Breast conserving surgery OT - Chronic pain OT - Mastectomy OT - Quality of life EDAT- 2026/08/11 12:37 MHDA- 2026/08/11 12:38 CRDT- 2026/08/11 09:52 PHST- 2025/10/12 00:00 [received] PHST- 2026/04/12 00:00 [accepted] PHST- 2026/08/11 12:38 [medline] PHST- 2026/08/11 12:37 [pubmed] PHST- 2026/08/11 09:52 [entrez] AID - /article/view/6520 [pii] AID - 10.62438/tunismed.v104i05.6520 [doi] PST - epublish SO - Tunis Med. 2026 May 1;104(4):678-682. doi: 10.62438/tunismed.v104i05.6520. PMID- 42577167 OWN - NLM STAT- MEDLINE DCOM- 20260811 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Latent profiles of problematic internet use and their associations with physical activity levels among college students: a cross-sectional study. PG - 1818418 LID - 10.3389/fpubh.2026.1818418 [doi] LID - 1818418 AB - OBJECTIVE: To identify latent profiles of problematic internet use (PIU) among college students and examine their associations with physical activity (PA) levels. METHODS: A stratified cluster sampling survey was conducted among 2,660 college students from central China. Problematic short video, social media, and internet game use were assessed using validated scales, and PA level was measured using the Physical Activity Rating Scale-3. Latent profile analysis was performed to identify PIU profiles. Multinomial logistic regression was used to examine the associations between PA levels and profile membership after adjusting for sociodemographic characteristics. RESULTS: Four heterogeneous latent profiles of problematic internet use were identified among college students: the Low-risk problematic use profile (n = 1,630, 61.28%), the Social media-dominant problematic use profile (n = 304, 11.43%), the Gaming-dominant problematic use profile (n = 478, 17.97%), and the High-risk problematic use profile (n = 248, 9.32%). Multinomial logistic regression analyses showed that, compared with the Low-risk profile, male students had higher odds of membership in the Gaming-dominant profile (OR = 2.122, 95%CI:1.697-2.654) and the High-risk profile (OR = 1.714, 95%CI:1.292-2.273), but lower odds of membership in the Social media-dominant profile (OR = 0.767, 95%CI:0.598-0.983). Sophomore and junior students had significantly higher odds of membership in all three non-low-risk profiles, whereas senior students had significantly lower odds. Off-campus residence was associated with lower odds of membership in the Gaming-dominant profile (OR = 0.508, 95%CI:0.298-0.864). High-level physical activity was associated with lower odds of membership in the Social media-dominant (OR = 0.585, 95%CI:0.395-0.866), Gaming-dominant (OR = 0.371, 95%CI:0.255-0.539), and High-risk profiles (OR = 0.552, 95%CI:0.353-0.862). Moderate-level physical activity was associated with lower odds of membership only in the Gaming-dominant profile (OR = 0.795, 95%CI:0.632-0.999). CONCLUSION: PIU among college students exhibits substantial heterogeneity. The observed associations between PA levels and profile membership may inform targeted PIU prevention strategies. CI - Copyright (c) 2026 Peng, Zhou and Chen. FAU - Peng, Wenzhi AU - Peng W AD - Department of Physical Education Teaching and Research, Central South University, Changsha, Hunan, China. FAU - Zhou, Zeng AU - Zhou Z AD - Department of Physical Education Teaching and Research, Central South University, Changsha, Hunan, China. AD - College of Sports Science, Jishou University, Jishou, Hunan, China. FAU - Chen, Ziyi AU - Chen Z AD - College of Physical Education and Health, Guangxi Normal University, Guilin, Guangxi, China. LA - eng PT - Journal Article DEP - 20260727 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Male MH - *Students/statistics & numerical data/psychology MH - Cross-Sectional Studies MH - *Exercise MH - Female MH - Young Adult MH - China/epidemiology MH - Universities MH - *Internet Addiction Disorder/epidemiology MH - *Internet Use/statistics & numerical data MH - Surveys and Questionnaires MH - Adolescent MH - *Behavior, Addictive/epidemiology MH - Digital Media MH - Video Games/statistics & numerical data PMC - PMC13453751 OTO - NOTNLM OT - behavioral addiction OT - college students OT - latent profiles OT - physical activity levels OT - problematic internet use COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/11 06:35 MHDA- 2026/08/11 12:37 PMCR- 2026/07/27 CRDT- 2026/08/11 05:32 PHST- 2026/02/26 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/08/11 12:37 [medline] PHST- 2026/08/11 06:35 [pubmed] PHST- 2026/08/11 05:32 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1818418 [doi] PST - epublish SO - Front Public Health. 2026 Jul 27;14:1818418. doi: 10.3389/fpubh.2026.1818418. eCollection 2026. PMID- 42575069 OWN - NLM STAT- MEDLINE DCOM- 20260829 LR - 20260829 IS - 1873-3379 (Electronic) IS - 0891-4222 (Linking) VI - 176 DP - 2026 Sep TI - The longitudinal relationship between physical activity and social skills in children with autism: Basic psychological need satisfaction in exercise as a potential pathway. PG - 105362 LID - S0891-4222(26)00157-5 [pii] LID - 10.1016/j.ridd.2026.105362 [doi] AB - OBJECTIVE: To examine the longitudinal association between physical activity and social skills in children with autism and evaluate basic psychological need satisfaction in exercise as a potential longitudinal indirect pathway. METHODS: A three-wave longitudinal study was conducted in seven special education schools in Sichuan, Hunan, and Yunnan, China. Data were collected in November 2025, February 2026, and May 2026 at three-month intervals. Primary caregivers completed all questionnaires. After excluding attrition cases and invalid responses, 584 valid cases were retained. Physical activity, basic psychological need satisfaction in exercise, and social skills were assessed using validated Chinese scales. Measurement invariance testing and fixed-effect cross-lagged panel modeling were supplemented by a longitudinal latent-variable model, demographic- and physical-activity-scaling sensitivity analyses, and random-effects cross-lagged panel modeling. RESULTS: The preliminary bivariate CLPM showed inadequate global fit; therefore, its path coefficients were not used for substantive inference. In the primary three-variable longitudinal model, physical activity showed consistent positive prospective associations with social skills across both adjacent intervals (beta = 0.274 and 0.169, respectively; both p < 0.001). T1 physical activity was positively associated with T2 basic psychological need satisfaction in exercise (beta = 0.105, p = 0.002), which was subsequently associated with higher T3 social skills (beta = 0.188, p < 0.001). This pathway yielded a small positive standardized indirect effect (effect = 0.020, 95% CI [0.007, 0.039], p = 0.015). The directly estimated association between T1 physical activity and T3 social skills also remained positive (effect = 0.137, 95% CI [0.068, 0.213], p < 0.001), indicating that basic psychological need satisfaction in exercise accounted for part, but not all, of the longitudinal association. The focal indirect effect was replicated in the longitudinal latent-variable, covariate-adjusted, and alternative physical-activity-scoring analyses, with estimates ranging from 0.022 to 0.029. The targeted random-effects model yielded a comparable point estimate (0.022), although with greater uncertainty (95% CI [-0.012, 0.056]). CONCLUSION: These findings position physical activity as a recurring developmental context associated with later social-skill development in children with autism and indicate that basic psychological need satisfaction in exercise may modestly help explain this longitudinal relationship. They further suggest that the social-developmental relevance of physical activity may depend partly on whether participation supports autonomy, competence, and relatedness, underscoring the importance of considering the psychological quality of participation alongside activity volume. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Chen, Longjiang AU - Chen L AD - School of Physical Education, Yunnan Normal University, Kunming, China. Electronic address: longjiang-chen@outlook.com. FAU - Mei, Zhengyang AU - Mei Z AD - School of Physical Education, Central China Normal University, Wuhan, China. Electronic address: meizhengyang0823@126.com. FAU - Cai, Chenyi AU - Cai C AD - School of Physical Education, Southwest University, Chongqing, China. Electronic address: caichenyi2002@126.com. FAU - Yin, Tian AU - Yin T AD - School of Physical Education, Yunnan Minzu University, Kunming, China. Electronic address: shanliangdenanzihan@ymu.edu.cn. FAU - Xiang, Yian AU - Xiang Y AD - Department of Rehabilitation Medicine, Lishui Municipal Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, China. Electronic address: xyian@126.com. LA - eng PT - Journal Article DEP - 20260810 PL - United States TA - Res Dev Disabil JT - Research in developmental disabilities JID - 8709782 SB - IM MH - Humans MH - Male MH - Longitudinal Studies MH - Female MH - Child MH - *Exercise/psychology MH - *Social Skills MH - *Personal Satisfaction MH - *Autistic Disorder/psychology MH - China MH - Education, Special MH - *Autism Spectrum Disorder/psychology MH - Surveys and Questionnaires OTO - NOTNLM OT - Basic psychological need satisfaction in exercise OT - Children with autism OT - Longitudinal study OT - Physical activity OT - Social skills COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/11 00:35 MHDA- 2026/08/29 23:35 CRDT- 2026/08/10 18:10 PHST- 2026/06/20 00:00 [received] PHST- 2026/07/23 00:00 [revised] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/08/29 23:35 [medline] PHST- 2026/08/11 00:35 [pubmed] PHST- 2026/08/10 18:10 [entrez] AID - S0891-4222(26)00157-5 [pii] AID - 10.1016/j.ridd.2026.105362 [doi] PST - ppublish SO - Res Dev Disabil. 2026 Sep;176:105362. doi: 10.1016/j.ridd.2026.105362. Epub 2026 Aug 10. PMID- 42574849 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260825 IS - 1873-6297 (Electronic) IS - 0001-6918 (Linking) VI - 269 DP - 2026 Sep TI - Drivers of sustainable sport behavior in university students: Model development and validation. PG - 107572 LID - S0001-6918(26)01373-9 [pii] LID - 10.1016/j.actpsy.2026.107572 [doi] AB - This study developed and evaluated an integrative model of sustainable sport behavior among university students, defined as a theoretically linked but noninterchangeable pair of outcomes: maintenance of sport and physical activity participation and eco-aligned sport choices. Drawing on the Theory of Planned Behavior (TPB), self-regulation, motivation, social influence, and ecological perspectives, the study examined the confirmatory contribution of core TPB constructs and the incremental contribution of selected psychological, social, environmental, and sustainability-related factors. A two-phase design was used. In Phase 1, newly developed items measuring eco-aligned sport choices, visible sustainability practices, and perceived gendered/cultural barriers were reviewed by experts, refined through cognitive interviews, and examined using exploratory factor analysis with 284 students. In Phase 2, confirmatory factor analysis, measurement invariance testing, and structural equation modeling were conducted with 948 undergraduate students; 412 students provided behavior data at an eight-week follow-up. The measurement analyses supported two related first-order dimensions; a second-order score was retained for concise reporting, although the correlated two-factor solution showed a small fit advantage. Perceived behavioral control showed the largest association with intention, and T1 intention was prospectively associated with T2 behavior after baseline behavior was considered. Self-efficacy, perceived competence, intrinsic motivation, peer support, scheduling compatibility, access, physical environment quality, and visible sustainability practices showed additional, generally small associations. Statistical indirect associations through stress and anxiety were interpreted cautiously. Measurement invariance was evaluated for women and men and across academic stage. The findings indicate that sustainable sport behavior is associated with both individual regulation and inclusive, accessible, schedule-sensitive, and visibly sustainable campus conditions; however, the 43.5% follow-up retention, self-report measurement, and the observational nature of most paths limit causal inference. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Chen, Xiao AU - Chen X AD - Faculty of Sports Science and Technology, Bangkok Thonburi University, Bangkok, Thailand. Electronic address: chenxiao2152@outlook.com. FAU - Esmaeili, Ali AU - Esmaeili A AD - Allameh Tabataba'i University, Tehran, Iran. Electronic address: ali.esmaeili@atu.ac.ir. LA - eng PT - Journal Article PT - Validation Study DEP - 20260810 PL - Netherlands TA - Acta Psychol (Amst) JT - Acta psychologica JID - 0370366 SB - IM MH - Humans MH - *Students/psychology MH - Female MH - Universities MH - Theory of Planned Behavior MH - *Sports/psychology MH - *Motivation MH - Male MH - Young Adult MH - Self Efficacy MH - Adult MH - Intention MH - Self-Control MH - *Models, Psychological MH - Adolescent MH - *Exercise/psychology OTO - NOTNLM OT - Campus sustainability OT - Motivation OT - Perceived behavioral control OT - Physical activity OT - Structural equation modeling OT - Sustainable sport behavior OT - University students COIS- Declaration of competing interest The authors declare that they have no competing interests. EDAT- 2026/08/11 00:35 MHDA- 2026/08/25 05:34 CRDT- 2026/08/10 18:02 PHST- 2026/06/15 00:00 [received] PHST- 2026/07/31 00:00 [revised] PHST- 2026/07/31 00:00 [accepted] PHST- 2026/08/25 05:34 [medline] PHST- 2026/08/11 00:35 [pubmed] PHST- 2026/08/10 18:02 [entrez] AID - S0001-6918(26)01373-9 [pii] AID - 10.1016/j.actpsy.2026.107572 [doi] PST - ppublish SO - Acta Psychol (Amst). 2026 Sep;269:107572. doi: 10.1016/j.actpsy.2026.107572. Epub 2026 Aug 10. PMID- 42571161 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260809 LR - 20260826 IS - 2325-9671 (Print) IS - 2325-9671 (Electronic) IS - 2325-9671 (Linking) VI - 14 IP - 8 DP - 2026 Aug TI - Association of Mental Health, Quality of Life, and Sport Specialization Using the Wisconsin Sport Specialization Questionnaire Among Adolescent Athletes. PG - 23259671261467554 LID - 10.1177/23259671261467554 [doi] LID - 23259671261467554 AB - BACKGROUND: Higher sport specialization levels have been associated with increased mental health issues. A recently validated questionnaire, the Wisconsin Sport Specialization Questionnaire (WISSQ), may provide clarity about the degree of sport specialization to investigate associations with mental health/quality of life (QoL) among adolescent athletes. PURPOSE: To examine the association of sports specialization, as measured by the WISSQ, and mental health/QoL outcomes among uninjured adolescent athletes, as well as the effect of age on the interaction between mental health/QoL outcomes and sport specialization. STUDY DESIGN: Cross-sectional study; Level of evidence, 2. METHODS: During the preseason assessment, performed in July and August from 2023 to 2025, participants completed the WISSQ and the Patient-Reported Outcomes Measurement Information System (PROMIS) Global 25 (Version 1.1). A multiple linear regression model was constructed that evaluated the association between 6 PROMIS domains and WISSQ ratings, adjusting for age, sex, and self-reported physical activity volume. To address the secondary purpose, linear regression models with an interaction term were used to examine the association between each PROMIS domain and age with sport specialization. RESULTS: A total of 251 uninjured adolescent athletes completed the study (mean +/- SD age, 15.9 +/- 1.4 years). The mean WISSQ rating was 54.1 (SD, 15.4). Results from the multivariable linear regression model indicated that higher depressive symptoms (beta = 0.46; 95% CI, 0.16-0.76; P = .003) and pain interference ratings (beta = 0.30; 95% CI, 0.02-0.57; P = .03) were significantly associated with higher WISSQ ratings, after adjusting for baseline physical activity, age, sex, and history of anxiety or depression diagnosis. For the secondary purpose, there was a significant interaction between fatigue and age group on sport specialization (beta coefficient = 0.49; 95% CI, 0.02-0.95; P = .04). The relationship between fatigue and sport specialization differed by age: a stronger association occurred among older adolescents than younger adolescents. There were no other age x QoL interactions. CONCLUSION: This study demonstrated that higher depressive symptoms and pain interference ratings were significantly associated with higher WISSQ ratings. In addition, there was a significant interaction between fatigue and age group, with a stronger association identified among older adolescents. Higher specialized and older adolescent athletes may be more at risk for developing mental health/QoL concerns and may benefit from more targeted screening. CI - (c) The Author(s) 2026. FAU - Meyers, Rachel AU - Meyers R AD - Sports Medicine Center, Children's Hospital Colorado, Aurora, Colorado, USA. FAU - Petersen, Sarah AU - Petersen S AD - Sports Medicine Center, Children's Hospital Colorado, Aurora, Colorado, USA. AD - Department of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA. FAU - Hogg-Cornejo, Veronica AU - Hogg-Cornejo V AD - Department of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA. FAU - Sweeney, Emily AU - Sweeney E AUID- ORCID: 0000-0002-5546-4668 AD - Sports Medicine Center, Children's Hospital Colorado, Aurora, Colorado, USA. AD - Department of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA. FAU - Armento, Aubrey AU - Armento A AD - Sports Medicine Center, Children's Hospital Colorado, Aurora, Colorado, USA. AD - Department of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA. FAU - Howell, David AU - Howell D AUID- ORCID: 0000-0002-2955-0191 AD - Sports Medicine Center, Children's Hospital Colorado, Aurora, Colorado, USA. AD - Department of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA. FAU - Walker, Gregory AU - Walker G AD - Sports Medicine Center, Children's Hospital Colorado, Aurora, Colorado, USA. AD - Department of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA. LA - eng GR - R13 AR080451/AR/NIAMS NIH HHS/United States GR - UL1 TR002535/TR/NCATS NIH HHS/United States GR - R01 NS100952/NS/NINDS NIH HHS/United States GR - K12 TR004412/TR/NCATS NIH HHS/United States GR - R03 HD094560/HD/NICHD NIH HHS/United States GR - UM1 TR004399/TR/NCATS NIH HHS/United States GR - R43 NS108823/NS/NINDS NIH HHS/United States PT - Journal Article DEP - 20260806 PL - United States TA - Orthop J Sports Med JT - Orthopaedic journal of sports medicine JID - 101620522 PMC - PMC13451724 OTO - NOTNLM OT - WISSQ OT - adolescence OT - mental health OT - sport specialization COIS- One or more of the authors has declared the following potential conflict of interest or source of funding: Research reported in this publication was supported by the Denver Broncos Foundation. The funding source played no role in the research design, data collection, data analysis, or interpretation of results. Unrelated to this study, D.H. has received research support from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (R03HD094560,), the National Institute of Neurological Disorders and Stroke (R01NS100952, R43NS108823), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (1R13AR080451), the 59th Medical Wing Department of the Air Force, MINDSOURCE Brain Injury Network, the Tai Foundation, and the Colorado Clinical and Translational Sciences Institute (UL1 TR002535-05). A.A. has received funding from the National Center for Advancing Translational Sciences/Clinical and Translational Science Awards Program/Colorado Clinical and Translational Sciences Institute (K12 TR004412, UM1 TR004399). EDAT- 2026/08/09 06:41 MHDA- 2026/08/09 06:42 PMCR- 2026/08/06 CRDT- 2026/08/09 03:58 PHST- 2026/06/15 00:00 [received] PHST- 2026/06/21 00:00 [accepted] PHST- 2026/08/09 06:42 [medline] PHST- 2026/08/09 06:41 [pubmed] PHST- 2026/08/09 03:58 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 10.1177_23259671261467554 [pii] AID - 10.1177/23259671261467554 [doi] PST - epublish SO - Orthop J Sports Med. 2026 Aug 6;14(8):23259671261467554. doi: 10.1177/23259671261467554. eCollection 2026 Aug. PMID- 42570575 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260926 IS - 1872-7727 (Electronic) IS - 0720-048X (Linking) VI - 204 DP - 2026 Nov TI - Ultrasound-based area ossification ratios for pediatric radiographic bone age: Development and internal validation of a radiation-free nomogram. PG - 113135 LID - S0720-048X(26)00483-3 [pii] LID - 10.1016/j.ejrad.2026.113135 [doi] AB - PURPOSE: Radiographic bone age (BA) assessment involves ionizing radiation, limiting its utility in frequent longitudinal follow-up. This study developed and internally validated a radiation-free nomogram based on multi-site two-dimensional ultrasound area ossification ratios (ORs) to assess Zhonghua-05 (RUS-CHN) radiographic bone age and predicted adult height (PAH), evaluating its incremental value over chronological age. METHODS: In this single-center prospective study (August 2024 approximately December 2025), 1,053 children aged 3-15 years were randomized into training and validation sets (7:3). Ultrasound area ORs of the left distal radius, ulna, and femur were calculated. Using radiographic RUS-CHN BA as the reference standard, predictor variables were selected via LASSO regression to construct the nomogram. Model performance was evaluated across the cohort and within developmental discordance subgroups (advanced/delayed maturation). RESULTS: Ultrasound OR measurements showed excellent reproducibility (ICC > 0.88). In the validation set, the nomogram predicted RUS-CHN BA with a mean absolute error (MAE) of 2.94 months (RMSE = 3.67 months, R(2) = 0.989). Crucially, in children with advanced or delayed maturation, the nomogram reduced BA prediction MAE by over 60 % compared to a baseline clinical feature model. The secondary model for PAH achieved an MAE of 0.63 cm. CONCLUSIONS: Multi-site ultrasound area ORs provide a highly reproducible, radiation-free index of skeletal maturity. As an internally validated, standard-specific research tool, the nomogram estimated RUS-CHN radiographic BA and corrected age-anchoring bias in children with discordant maturation. Because its numeric calibration is specific to the RUS-CHN standard, external multicenter and longitudinal validation is required before clinical use. ABBREVIATIONS: BA, Bone age; BMI, Body mass index; CI, Confidence interval; GP, Greulich Pyle; ICC, Intraclass correlation coefficient; LASSO, Least absolute shrinkage and selection operator; LoA, Limits of agreement; MAE, Mean absolute error; MPH, Mid‑parental height; OR, Area ossification ratio; PAH, Predicted adult height; QC, Quality control; RMSE, Root mean square error; RUS‑CHN, Radius, ulna, and short bones RUS skeletal‑maturity score, Chinese standard; SOP, Standard operating procedure; TRIPOD, Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Deng, Yongzhi AU - Deng Y AD - School of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China. FAU - Qiang, Lu AU - Qiang L AD - Department of Radiology, The First People's Hospital of Chenzhou, Chenzhou, Hunan 423000, China. FAU - Wang, Tailong AU - Wang T AD - Department of Ultrasound, The First People's Hospital of Chenzhou, Chenzhou, Hunan 423000, China. FAU - Zheng, Haijun AU - Zheng H AD - Department of Radiology, The First People's Hospital of Chenzhou, Chenzhou, Hunan 423000, China. FAU - He, Yucheng AU - He Y AD - Department of Radiology, The First People's Hospital of Chenzhou, Chenzhou, Hunan 423000, China. FAU - Li, Yifang AU - Li Y AD - Academy for Engineering and Technology, Fudan University, Shanghai 200433, China. FAU - Zhu, Weihong AU - Zhu W AD - Department of Ultrasound, The First People's Hospital of Chenzhou, Chenzhou, Hunan 423000, China. Electronic address: zhu_wei_hong@126.com. FAU - Li, Yudan AU - Li Y AD - Department of Ultrasound, The Third People's Hospital of Shenzhen, Shenzhen, Guangdong 518000, China. Electronic address: liyudan2026@163.com. LA - eng PT - Journal Article PT - Validation Study DEP - 20260805 PL - Ireland TA - Eur J Radiol JT - European journal of radiology JID - 8106411 SB - IM MH - Humans MH - *Age Determination by Skeleton/methods MH - *Nomograms MH - Child MH - Ultrasonography/methods MH - Reproducibility of Results MH - Child, Preschool MH - Female MH - Male MH - *Osteogenesis/physiology MH - Adolescent MH - Prospective Studies OTO - NOTNLM OT - Area ossification ratio OT - Bone age OT - LASSO OT - Nomogram OT - Predicted adult height OT - RUS-CHN OT - Ultrasound COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/09 00:43 MHDA- 2026/09/26 05:34 CRDT- 2026/08/08 18:07 PHST- 2026/06/17 00:00 [received] PHST- 2026/07/25 00:00 [revised] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/09/26 05:34 [medline] PHST- 2026/08/09 00:43 [pubmed] PHST- 2026/08/08 18:07 [entrez] AID - S0720-048X(26)00483-3 [pii] AID - 10.1016/j.ejrad.2026.113135 [doi] PST - ppublish SO - Eur J Radiol. 2026 Nov;204:113135. doi: 10.1016/j.ejrad.2026.113135. Epub 2026 Aug 5. PMID- 42551383 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260825 IS - 1873-6297 (Electronic) IS - 0001-6918 (Linking) VI - 269 DP - 2026 Sep TI - Fatigue in adolescent girls is linked to heavy menstrual bleeding, meal skipping and nicotine use - not iron deficiency. PG - 107568 LID - S0001-6918(26)01369-7 [pii] LID - 10.1016/j.actpsy.2026.107568 [doi] AB - Fatigue is common among adolescent girls, and iron deficiency is often considered a potential contributing factor. However, the association between iron status and self-reported fatigue in this population remains insufficiently understood. In a cross-sectional study of 485 post-menarchal girls aged 15-19 years, we examined associations between iron status, menstrual health, lifestyle factors, fatigue, and quality of life. Participants completed validated measures of fatigue (Pediatric Quality of Life Multidimensional Fatigue Scale) and quality of life (KIDSCREEN-10), and provided blood samples for ferritin and hemoglobin assessment. Iron deficiency was present in 37.7% of participants and anemia in 7.7%. Neither iron deficiency nor anemia was associated with fatigue or quality of life in crude analyses. In contrast, heavy menstrual bleeding, daily nicotine use, and skipping breakfast or school lunch were associated with higher fatigue and lower quality of life. After adjustment for potential confounders, higher ferritin and hemoglobin levels were associated with greater fatigue, while heavy menstrual bleeding remained consistently associated with fatigue. These findings suggest that fatigue in adolescent girls is more closely related to menstrual health and everyday behavioral factors than to iron status. The results support a multidimensional perspective on adolescent fatigue and highlight the importance of considering behavioral and psychosocial influences when assessing fatigue and well-being. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Stubbendorff, Anna AU - Stubbendorff A AD - Nutritional Epidemiology, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden. Electronic address: anna.stubbendorff@med.lu.se. FAU - Borgfors, Alice AU - Borgfors A AD - Center for Primary Health Care Research, Department of Clinical Sciences, Malmo, Lund University, Sweden; University Clinic Primary Care Skane, Region Skane, Sweden. FAU - Bolmsjo, Beata Borgstrom AU - Bolmsjo BB AD - Center for Primary Health Care Research, Department of Clinical Sciences, Malmo, Lund University, Sweden; University Clinic Primary Care Skane, Region Skane, Sweden. FAU - Vinge, Fredrik AU - Vinge F AD - Center for Primary Health Care Research, Department of Clinical Sciences, Malmo, Lund University, Sweden; University Clinic Primary Care Skane, Region Skane, Sweden. FAU - Midlov, Patrik AU - Midlov P AD - Center for Primary Health Care Research, Department of Clinical Sciences, Malmo, Lund University, Sweden; University Clinic Primary Care Skane, Region Skane, Sweden. FAU - Wolff, Moa AU - Wolff M AD - Center for Primary Health Care Research, Department of Clinical Sciences, Malmo, Lund University, Sweden; University Clinic Primary Care Skane, Region Skane, Sweden. LA - eng PT - Journal Article DEP - 20260804 PL - Netherlands TA - Acta Psychol (Amst) JT - Acta psychologica JID - 0370366 RN - 9007-73-2 (Ferritins) SB - IM MH - Humans MH - Female MH - Adolescent MH - *Fatigue/epidemiology/etiology/blood MH - Cross-Sectional Studies MH - Quality of Life MH - *Iron Deficiencies MH - *Menorrhagia/epidemiology/complications MH - Ferritins/blood MH - Young Adult MH - *Anemia, Iron-Deficiency/epidemiology MH - *Tobacco Use/epidemiology MH - *Feeding Behavior/physiology OTO - NOTNLM OT - Adolescent OT - Fatigue OT - Heavy menstrual bleeding, nicotine, diet OT - Iron deficiency OT - Teenage COIS- Declaration of competing interest All authors declare no competing interests. EDAT- 2026/08/09 15:21 MHDA- 2026/08/25 05:34 CRDT- 2026/08/04 18:10 PHST- 2026/06/09 00:00 [received] PHST- 2026/07/27 00:00 [revised] PHST- 2026/07/30 00:00 [accepted] PHST- 2026/08/25 05:34 [medline] PHST- 2026/08/09 15:21 [pubmed] PHST- 2026/08/04 18:10 [entrez] AID - S0001-6918(26)01369-7 [pii] AID - 10.1016/j.actpsy.2026.107568 [doi] PST - ppublish SO - Acta Psychol (Amst). 2026 Sep;269:107568. doi: 10.1016/j.actpsy.2026.107568. Epub 2026 Aug 4. PMID- 42570408 OWN - NLM STAT- MEDLINE DCOM- 20260822 LR - 20260822 IS - 1873-4162 (Electronic) IS - 1344-6223 (Linking) VI - 85 DP - 2026 Sep TI - The relationship between postmortem heart weight and morphometric measurements and body mass index: an investigation of forensic autopsy cases. PG - 102916 LID - S1344-6223(26)00144-6 [pii] LID - 10.1016/j.legalmed.2026.102916 [doi] AB - The postmortem evaluation of heart weight and morphometric measurements presents challenges, highlighting the need for reliable reference values. This study aimed to establish population-specific data for the Turkish population. A retrospective analysis was performed on autopsy cases aged >/=18 years between January 1, 2018, and December 31, 2019, at the relevant forensic morgue department. Statistical analyses were conducted using the Number Cruncher Statistical System. Of the included cases, 20.2% were female and 79.8% male. The mean age and body mass index were 52.32 +/- 20.29 years and 28.34 +/- 7.29 kg/m(2) in females, and 46.86 +/- 17.06 years and 26.54 +/- 5.43 kg/m(2) in males. Heart weight increased with age up to 80 years in both sexes and was independently associated with body mass index in multivariable regression analysis. The mean heart weight was 507.08 +/- 129.12 g in cardiovascular-related deaths and 410.35 +/- 128.94 g in other natural deaths. In hearts without detected cardiac pathology, the mean weight was 277.74 g in females and 350.11 g in males. Average ventricular wall thickness was 0.31 cm (right) and 1.27 cm (left). Valve circumferences were larger in males. Multivariate regression analysis revealed moderate explanatory power (R(2) = 32.5% in cases with pathology and 48.0% in those without pathology) for heart weight. This study provides population-specific reference data for postmortem heart weight and morphometric parameters within the methodological framework of a retrospective autopsy cohort in the Turkish population. These findings may support forensic autopsy practice, though further studies are needed for validation. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Tat, Emrah AU - Tat E AD - The Group Presidency of Forensic Medicine, Council of Forensic Medicine, Ministry of Justice, Antalya, Turkiye. Electronic address: ab205132@adalet.gov.tr. FAU - Sogukpinar, Veysel Osman AU - Sogukpinar VO AD - The Group Presidency of Forensic Medicine, Council of Forensic Medicine, Ministry of Justice, Van, Turkiye. Electronic address: v.o.s23@hotmail.com. FAU - Arpak, Baha Berk AU - Arpak BB AD - The Council of Forensic Medicine, Ministry of Justice, Istanbul, Turkiye. Electronic address: bahaberk@gmail.com. FAU - Uzun, Ibrahim AU - Uzun I AD - The Council of Forensic Medicine, Ministry of Justice, Istanbul, Turkiye. Electronic address: ibrahim.uzun@iuc.edu.tr. LA - eng PT - Journal Article DEP - 20260708 PL - Ireland TA - Leg Med (Tokyo) JT - Legal medicine (Tokyo, Japan) JID - 100889186 SB - IM MH - Humans MH - Male MH - Female MH - Middle Aged MH - Aged MH - *Body Mass Index MH - Adult MH - Retrospective Studies MH - Organ Size MH - Aged, 80 and over MH - Autopsy MH - *Heart/anatomy & histology MH - Adolescent MH - Turkey MH - Young Adult MH - Forensic Pathology MH - Reference Values MH - *Myocardium/pathology OTO - NOTNLM OT - Body mass index OT - Forensic autopsy OT - Heart morphometric measurements OT - Heart weight OT - Reference values OT - Turkish population COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/08 23:10 MHDA- 2026/08/22 23:43 CRDT- 2026/08/08 18:01 PHST- 2026/02/03 00:00 [received] PHST- 2026/04/21 00:00 [revised] PHST- 2026/06/05 00:00 [accepted] PHST- 2026/08/22 23:43 [medline] PHST- 2026/08/08 23:10 [pubmed] PHST- 2026/08/08 18:01 [entrez] AID - S1344-6223(26)00144-6 [pii] AID - 10.1016/j.legalmed.2026.102916 [doi] PST - ppublish SO - Leg Med (Tokyo). 2026 Sep;85:102916. doi: 10.1016/j.legalmed.2026.102916. Epub 2026 Jul 8. PMID- 42569675 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260808 LR - 20260813 IS - 2667-3681 (Electronic) IS - 2667-3681 (Linking) VI - 19 DP - 2026 Sep TI - Creation and validation of the 8-Item Brief Emotional Eating Scale (BEES-8, version 1.0) in youth and adults. PG - 100307 LID - 10.1016/j.obpill.2026.100307 [doi] LID - 100307 AB - INTRODUCTION: Although several instruments have been developed to assess emotional eating, no measure has yet been identified that evaluates this construct based on the eight basic emotions. Assessing emotional eating is particularly important because it represents a relevant factor associated with overweight and obesity. In this context, the aim of the present study was to develop and validate the Brief Emotional Eating Scale based on the Eight Basic Emotions (BEES-8, version 1.0) in a sample of Peruvian youth and adults. METHODS: A cross-sectional psychometric study was conducted. The non-probabilistic sample consisted of 481 participants of both sexes, with a mean age of 31.72 years (SD = 12.08), recruited from Metropolitan Lima, Peru. The Brief Emotional Eating Scale (BEES-8, v1.0) and the Generalized Anxiety Disorder Scale (GAD-2) were administered. RESULTS: A second-order confirmatory factor analysis demonstrated an adequate model fit (CFI = 0.976, TLI = 0.962, SRMR = 0.029, RMSEA = 0.076). Furthermore, BEES-8 (v1.0) scores showed a positive and statistically significant correlation with generalized anxiety (r = 0.449, p < 0.001), providing evidence of validity based on relationships with other variables. Finally, the scale demonstrated adequate overall reliability (omega = 0.919). CONCLUSION: The BEES-8 (v1.0) demonstrated adequate evidence of validity and reliability for assessing emotional eating based on the eight basic emotions. It constitutes a potentially useful tool for research and for the study of eating behaviors associated with emotional states, as well as variables related to overweight, obesity, and emotional regulation. CI - (c) 2026 Published by Elsevier Inc. on behalf of Obesity Medicine Association. FAU - Javier-Aliaga, David AU - Javier-Aliaga D AD - Graduate School,Universidad Peruana Union, Lima, Peru. AD - Advanced Research Center in Neuroscience, Lifestyles, Gastrointestinal health, Obesity and Diabetes (ARCeNeLGOD), Lima, Peru. FAU - Quinteros-Zuniga, Damaris AU - Quinteros-Zuniga D AD - Graduate School,Universidad Peruana Union, Lima, Peru. LA - eng PT - Journal Article DEP - 20260724 PL - United States TA - Obes Pillars JT - Obesity pillars JID - 9918697364706676 PMC - PMC13450208 OTO - NOTNLM OT - Adult OT - Emotional eating OT - Factor analysis OT - Obesity OT - Validation OT - Young adult COIS- The authors declare no financial, institutional, employment, or personal conflicts of interest related to the preparation of this manuscript. EDAT- 2026/08/08 23:10 MHDA- 2026/08/08 23:11 PMCR- 2026/07/24 CRDT- 2026/08/08 06:32 PHST- 2026/06/19 00:00 [received] PHST- 2026/07/22 00:00 [revised] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/08/08 23:11 [medline] PHST- 2026/08/08 23:10 [pubmed] PHST- 2026/08/08 06:32 [entrez] PHST- 2026/07/24 00:00 [pmc-release] AID - S2667-3681(26)00063-X [pii] AID - 100307 [pii] AID - 10.1016/j.obpill.2026.100307 [doi] PST - epublish SO - Obes Pillars. 2026 Jul 24;19:100307. doi: 10.1016/j.obpill.2026.100307. eCollection 2026 Sep. PMID- 42568061 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20261027 IS - 2047-9980 (Electronic) IS - 2047-9980 (Linking) VI - 15 IP - 16 DP - 2026 Aug 18 TI - Dietary Approaches to Stop Hypertension Score Trajectories From Early to Middle Adulthood and Coronary Artery Calcium Progression in Middle Age. PG - e044564 LID - 10.1161/JAHA.125.044564 [doi] LID - e044564 AB - BACKGROUND: The Dietary Approaches to Stop Hypertension (DASH) diet reduces blood pressure and cardiovascular disease risk, but its impact on later coronary artery calcium (CAC) progression is unclear. This study aimed to identify DASH score trajectories from early to middle adulthood and assess their association with CAC progression in middle age, exploring the potential mediating factors. METHODS: We conducted a prospective analysis of 2238 Black and White adults who were aged 18 to 30 years at CARDIA (Coronary Artery Risk Development in Young Adults) baseline and were followed from study year 20 to year 25. DASH score trajectories from early to middle adulthood were determined using latent class analysis. The primary end point was CAC progression, a validated measure of plaque progression, defined as a >2.5 square root increase in CAC score between years 20 and 25. RESULTS: Two distinct DASH score trajectories were identified: the low-increasing and high-decreasing trajectories. In the fully adjusted model, participants in the high-decreasing trajectory had a 21% lower risk of CAC progression compared with those in the low-increasing trajectory (hazard ratio, 0.79 [95% CI, 0.65-0.98]; P=0.028). The association was partially mediated by diastolic blood pressure, insulin, uric acid, and lipid profiles. CONCLUSIONS: DASH score trajectories vary from early to middle adulthood. Maintaining high adherence to the DASH diet from early to middle adulthood is associated with reduced CAC progression in middle age, partially mediated by cardiometabolic risk factors. These findings support the importance of long-term adherence to a healthy dietary pattern for cardiovascular disease primary prevention. REGISTRATION: URL: https://www.clinicaltrials.gov; unique identifier: NCT00005130. FAU - Li, Xiong-Zhi AU - Li XZ AUID- ORCID: 0000-0001-8000-0227 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Xiong, Zhuo-Chao AU - Xiong ZC AUID- ORCID: 0000-0001-7520-409X AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Wang, Xin-Yi AU - Wang XY AUID- ORCID: 0009-0000-2285-6772 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Yu, Jin-Bo AU - Yu JB AUID- ORCID: 0000-0003-4341-3131 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Zhou, Jian AU - Zhou J AUID- ORCID: 0000-0002-5188-7129 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Zhong, Dong-Xiang AU - Zhong DX AUID- ORCID: 0000-0002-3997-7578 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Wu, Yi-Zhang AU - Wu YZ AUID- ORCID: 0000-0002-9693-8516 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Zhang, Bao-Wei AU - Zhang BW AUID- ORCID: 0000-0001-7043-0370 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Zhang, You-Ming AU - Zhang YM AUID- ORCID: 0000-0002-5014-8228 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Xia, Guang AU - Xia G AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Fan, Feng-Hua AU - Fan FH AUID- ORCID: 0009-0009-0049-6089 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Xie, Xin AU - Xie X AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Chen, Jie AU - Chen J AUID- ORCID: 0009-0003-2462-9559 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Song, Jie AU - Song J AUID- ORCID: 0009-0009-3238-4962 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Zhao, Jie AU - Zhao J AUID- ORCID: 0009-0004-3898-3505 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Li, Xiao-Rong AU - Li XR AUID- ORCID: 0000-0002-7295-655X AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Yang, Bing AU - Yang B AUID- ORCID: 0000-0001-5042-9305 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. LA - eng SI - ClinicalTrials.gov/NCT00005130 PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20260807 PL - England TA - J Am Heart Assoc JT - Journal of the American Heart Association JID - 101580524 SB - IM MH - Humans MH - *Dietary Approaches To Stop Hypertension MH - Male MH - Disease Progression MH - Female MH - *Coronary Artery Disease/prevention & control/diagnostic imaging/epidemiology MH - Adult MH - Prospective Studies MH - *Vascular Calcification/prevention & control/diagnostic imaging/epidemiology MH - Young Adult MH - Adolescent MH - Middle Aged MH - Blood Pressure MH - Risk Factors MH - *Hypertension/diet therapy MH - Age Factors MH - *Coronary Vessels/diagnostic imaging MH - Risk Assessment MH - Time Factors MH - United States/epidemiology PMC - PMC13695727 OTO - NOTNLM OT - cardiometabolic risk OT - cardiovascular disease OT - coronary artery calcium OT - diet OT - dietary approaches to stop hypertension OT - primary prevention COIS- None. EDAT- 2026/08/08 00:37 MHDA- 2026/08/19 17:43 PMCR- 2026/08/07 CRDT- 2026/08/07 23:54 PHST- 2026/08/19 17:43 [medline] PHST- 2026/08/08 00:37 [pubmed] PHST- 2026/08/07 23:54 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - JAH370941 [pii] AID - 10.1161/JAHA.125.044564 [doi] PST - ppublish SO - J Am Heart Assoc. 2026 Aug 18;15(16):e044564. doi: 10.1161/JAHA.125.044564. Epub 2026 Aug 7. PMID- 42567553 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260816 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 10 IP - 1 DP - 2026 Aug 7 TI - Context-specific predictors of mortality and the performance of paediatric sepsis scores in Tanzanian children: a secondary analysis of a prospective cohort study. LID - 10.1136/bmjpo-2026-004856 [doi] LID - e004856 AB - INTRODUCTION: Sepsis is a significant cause of global child mortality, disproportionately affecting resource-limited settings (RLS). Although clinical scores have been proposed in RLS, few have been externally validated. This study aimed to identify risk factors for mortality among Tanzanian children with sepsis and test three paediatric clinical scores in an RLS. METHODS: We conducted a secondary analysis of a prospective cohort study of 755 children (28 days to 14 years) with sepsis in the Emergency Department at Muhimbili National Hospital, Tanzania (July 2022-November 2024). Demographic, clinical and outcome data were collected. We performed multivariable logistic regression to identify independent predictors of in-hospital mortality. We then tested three clinical scores, Lambarene Organ Dysfunction Score (LODS), Blantyre quick Sequential Organ Failure Assessment (BqSOFA) and Phoenix Sepsis Score (PSS), using sensitivity, specificity and area under the receiver operating characteristic curve (AUC). RESULTS: In-hospital mortality was 20% (n=148); independent predictors included age, malnutrition, HIV status, referral status and delayed presentation (p<0.001). All three scores demonstrated strong discrimination for mortality (LODS AUC 0.79, 95% CI 0.75 to 0.83; BqSOFA AUC 0.75, 95% CI 0.71 to 0.79; PSS AUC 0.75, 95% CI 0.70 to 0.79) and differences between scores were not statistically significant (p=0.066). LODS showed high sensitivity (93%) and negative predictive value (96%). BqSOFA and PSS demonstrated high specificity (93% and 91%) and positive predictive values (51% and 56%), but low sensitivity (28% and 44%). CONCLUSIONS: Multiple clinical and sociodemographic factors were independently associated with mortality in children with sepsis. LODS demonstrated high sensitivity, while BqSOFA and PSS demonstrated high specificity; the scores' discriminative ability for mortality was not statistically significant. The identification of simple risk factors and moderately performing clinical scores provides a valuable opportunity to develop context-specific risk stratification tools for paediatric sepsis in RLS. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Sorensen, Abigail AU - Sorensen A AUID- ORCID: 0000-0001-8444-4968 AD - Pediatrics, UCSF, San Francisco, California, USA abigail.sorensen@ucsf.edu. FAU - Mussa, Raya AU - Mussa R AD - Emergency Medicine, Muhimbili National Hospital, Dar es Salaam, Tanzania. FAU - Sunzula, Erasto AU - Sunzula E AD - Emergency Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Mlele, Victoria AU - Mlele V AD - Emergency Medicine, Muhimbili National Hospital, Dar es Salaam, Tanzania. FAU - Oltman, Scott AU - Oltman S AD - Epidemiology and Biostatistics, UCSF, San Francisco, California, USA. FAU - Msemwa, Cecilia AU - Msemwa C AD - Emergency Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Mathias, Lushana AU - Mathias L AD - Emergency Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Baez-Maidana, Jazmin AU - Baez-Maidana J AD - Pediatrics, UCSF, San Francisco, California, USA. FAU - Sun, Kathleen AU - Sun K AD - Pediatrics, UCSF, San Francisco, California, USA. FAU - Mfinanga, Juma AU - Mfinanga J AD - Emergency Medicine, Muhimbili National Hospital, Dar es Salaam, Tanzania. FAU - Chu, Victoria AU - Chu V AD - Pediatrics, UCSF, San Francisco, California, USA. FAU - Hooft, Anneka AU - Hooft A AD - Emergency Medicine, UCSF, San Francisco, California, USA. FAU - Mkopi, Namala AU - Mkopi N AD - Emergency Medicine, Muhimbili National Hospital, Dar es Salaam, Tanzania. FAU - Kissoon, Niranjan AU - Kissoon N AD - Pediatrics, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada. FAU - Manyahi, Joel AU - Manyahi J AD - Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Sawe, Hendry AU - Sawe H AD - Emergency Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Kortz, Teresa AU - Kortz T AD - Pediatrics, UCSF, San Francisco, California, USA. LA - eng GR - D43 TW009343/TW/FIC NIH HHS/United States GR - K23 AI144029/AI/NIAID NIH HHS/United States GR - T32 HD049303/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20260807 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Tanzania/epidemiology MH - *Sepsis/mortality/diagnosis MH - Female MH - Male MH - Prospective Studies MH - Child, Preschool MH - Infant MH - *Hospital Mortality MH - Child MH - Adolescent MH - Risk Factors MH - Organ Dysfunction Scores MH - Resource-Limited Settings MH - ROC Curve MH - Infant, Newborn MH - Severity of Illness Index MH - Predictive Value of Tests MH - Sensitivity and Specificity PMC - PMC13475138 OTO - NOTNLM OT - Child OT - Child Health OT - Developing Countries OT - Low and Middle Income Countries OT - Mortality COIS- Competing interests: None declared. EDAT- 2026/08/08 00:37 MHDA- 2026/08/08 00:38 PMCR- 2026/08/07 CRDT- 2026/08/07 20:43 PHST- 2026/04/13 00:00 [received] PHST- 2026/07/15 00:00 [accepted] PHST- 2026/08/08 00:38 [medline] PHST- 2026/08/08 00:37 [pubmed] PHST- 2026/08/07 20:43 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - 10.1136/bmjpo-2026-004856 [pii] AID - bmjpo-2026-004856 [pii] AID - 10.1136/bmjpo-2026-004856 [doi] PST - epublish SO - BMJ Paediatr Open. 2026 Aug 7;10(1):e004856. doi: 10.1136/bmjpo-2026-004856. PMID- 42566616 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260813 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 32 DP - 2026 Aug 7 TI - Mid-upper arm circumference and diabetes/prediabetes in children and adolescents: A cross-sectional study using NHANES data. PG - e50083 LID - 10.1097/MD.0000000000050083 [doi] LID - e50083 AB - Mid-upper arm circumference (MUAC) is a simple anthropometric measure proposed as a marker of adiposity and cardiometabolic risk, but its relationship with diabetes and prediabetes in children and adolescents has not been fully characterized. This study assessed the association between MUAC and glycemic status in a nationally representative pediatric sample. We performed a cross-sectional analysis of pooled data from the 1999 to 2018 NHANES cycles, including 27,543 children and adolescents (age 6-19 years), of whom 2165 were classified as having diabetes or prediabetes by standard laboratory and self-report criteria. MUAC was measured at the midpoint of the right upper arm. Survey-weighted logistic regression models evaluated MUAC as both a continuous and categorical (quartiles) predictor of diabetes/prediabetes, adjusting for age, sex, race, education, poverty‑income ratio, body mass index, elevated blood pressure, and dyslipidemia. Restricted cubic spline analysis examined nonlinearity; subgroup analyses tested robustness. Higher MUAC was independently associated with higher odds of diabetes/prediabetes: per 1‑cm increase odds ratio: 1.04 (95% confidence interval [CI]: 1.01-1.08; P = .020). Versus Q1, adjusted odds ratios were Q2 2.57 (95% CI: 1.81-3.67), Q3 2.40 (95% CI: 1.60-3.61), Q4 2.49 (95% CI: 1.57-3.97) (all P < .001). Restricted cubic spline revealed a significant non‑linear association (P‑nonlinearity <.001) with an inflection near MUAC approximately 25.6 cm, above which odds increased more steeply. Subgroup analyses indicated stronger associations in females and in children <14 years. Associations remained consistent across the analyses. In this large, nationally representative sample of children and adolescents, elevated MUAC was independently associated with higher odds of diabetes and prediabetes, with evidence of a nonlinear dose-response and a threshold near 25.6 cm. Prospective studies are needed to validate cutoffs and explore the potential role of MUAC as a risk marker for dysglycemia. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Zhu, Li AU - Zhu L AUID- ORCID: 0009-0003-0595-3038 AD - Department of Pediatrics, Chengde Central Hospital, Chengde, Hebei, China. FAU - Li, He AU - Li H FAU - Li, Tao AU - Li T LA - eng GR - 202406A008/S&T Program of Chengde/ PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Adolescent MH - Female MH - Cross-Sectional Studies MH - *Prediabetic State/epidemiology/diagnosis MH - Child MH - *Arm/anatomy & histology MH - Male MH - Nutrition Surveys MH - *Diabetes Mellitus/epidemiology/diagnosis MH - Young Adult MH - Adiposity MH - Anthropometry/methods MH - Body Mass Index MH - United States/epidemiology PMC - PMC13456841 OTO - NOTNLM OT - children and adolescents OT - cross-sectional analysis OT - diabetes/prediabetes OT - mid‑upper arm circumference COIS- The authors have no funding and conflicts of interest to disclose. EDAT- 2026/08/07 18:36 MHDA- 2026/08/07 18:37 PMCR- 2026/08/07 CRDT- 2026/08/07 14:13 PHST- 2025/12/19 00:00 [received] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/08/07 18:37 [medline] PHST- 2026/08/07 18:36 [pubmed] PHST- 2026/08/07 14:13 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - 00005792-202608070-00062 [pii] AID - MD-D-25-18375 [pii] AID - 10.1097/MD.0000000000050083 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Aug 7;105(32):e50083. doi: 10.1097/MD.0000000000050083. PMID- 42564828 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260807 LR - 20260813 IS - 2574-2531 (Electronic) IS - 2574-2531 (Linking) VI - 9 IP - 4 DP - 2026 Aug TI - Identification of obesity risk factors in 3-12-year-old children and adolescents with prior respiratory tract infections via interpretable machine and deep learning models. PG - ooag061 LID - 10.1093/jamiaopen/ooag061 [doi] LID - ooag061 AB - BACKGROUNDS AND OBJECTIVES: Childhood obesity and respiratory tract infections (RTIs) are 2 major global public health issues that frequently co-occur and are closely interrelated. Early detection of children with prior RTIs who are at high obesity risk is crucial for targeted interventions. This study integrates interpretable machine learning (ML) models and a deep learning network to develop an obesity risk prediction model in a large pediatric cohort. METHODS: Cross-sectional data from 6509 children and adolescents aged 3-12 years with prior RTIs in Beijing and Tangshan were fed to 12 ML models to predict childhood obesity (versus children with normal weight). Bayesian optimization was applied to fine-tune model hyperparameters. Prediction performance was assessed using 8 metrics. Key predictive features were identified by SHapley Additive exPlanations (SHAP). The validity of the optimal ML model was verified by the sequential neural network model. RESULTS: Of 12 ML models, LightGBM achieved the optimal performance (accuracy: 0.8844, area under the curve [AUC]: 0.9491). SHAP analysis identified 20 key predictors, including child age, paternal body mass index (BMI), maternal BMI, birth length, birthweight, gestational age, eating speed, complementary feeding initiation age, screen time, breastfeeding duration, bedtime, maternal age, nighttime sleep, outdoor activity, dental caries, sedentary time, food allergies, family history of diabetes, and sex. The deep learning sequence network model further validated the predictive value of these features (accuracy: 0.8023, AUC: 0.8117), and the SHAP-driven feature importance rankings were in close line with LightGBM. CONCLUSIONS: Our LightGBM-based model enables effective prediction of obesity risk in children aged 3-12 years with prior RTIs, and the key features identified can inform early screening and facilitate personalized interventions. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the American Medical Informatics Association. FAU - Wang, Xiao-Qian AU - Wang XQ AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. FAU - Zheng, Fang-Jie-Yi AU - Zheng FJ AD - Center for Evidence-Based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China. FAU - Wang, Qiong AU - Wang Q AD - Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China. AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing 100029, China. FAU - Li, Che AU - Li C AD - Center for Evidence-Based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China. FAU - Zhang, Wen-Qian AU - Zhang WQ AD - Center for Evidence-Based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China. FAU - Zhang, Zhi-Xin AU - Zhang ZX AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing 100029, China. AD - Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China. FAU - Niu, Wen-Quan AU - Niu WQ AUID- ORCID: 0000-0003-1715-3372 AD - Center for Evidence-Based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China. LA - eng SI - Dryad/10.5061/dryad.gf1vhhn44 PT - Journal Article DEP - 20260806 PL - United States TA - JAMIA Open JT - JAMIA open JID - 101730643 PMC - PMC13445979 OTO - NOTNLM OT - Childhood obesity OT - SHapley Additive exPlanations OT - deep learning OT - machine learning OT - respiratory tract infection COIS- The authors declare that there is no conflict of interest regarding the publication of this article. EDAT- 2026/08/07 12:39 MHDA- 2026/08/07 12:40 PMCR- 2026/08/06 CRDT- 2026/08/07 06:08 PHST- 2026/01/05 00:00 [received] PHST- 2026/03/16 00:00 [revised] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/08/07 12:40 [medline] PHST- 2026/08/07 12:39 [pubmed] PHST- 2026/08/07 06:08 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - ooag061 [pii] AID - 10.1093/jamiaopen/ooag061 [doi] PST - epublish SO - JAMIA Open. 2026 Aug 6;9(4):ooag061. doi: 10.1093/jamiaopen/ooag061. eCollection 2026 Aug. PMID- 42560993 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 8 DP - 2026 TI - Prevalence of sleep disturbances and their association with quality of life among the general population in Qassim, Saudi Arabia. PG - e0347188 LID - 10.1371/journal.pone.0347188 [doi] LID - e0347188 AB - To the best of our knowledge, no previous study has assessed the relationship between sleep disturbances and quality of life in the general population of Qassim, Saudi Arabia. Therefore, this cross-sectional study aimed to evaluate the relationship between sleep disorders and quality of life and to determine how common sleep disturbances are in Qassim, Saudi Arabia. To this end, participants were randomly selected from public areas. Study data were collected through a survey covering sociodemographic details, health information, the Pittsburgh Sleep Quality Index (PSQI) to assess sleep quality, and the Short Form-12 to measure health-related quality of life. The reliability of the scales was confirmed using Cronbach's alpha. The association between sleep quality and quality of life was analyzed using t-tests, Pearson's correlation, and hierarchical multiple regression. Of 1,241 participants, 64.5% were females, 94.8% were Saudi nationals, and 64.8% were students. The mean global PSQI score was 7.38 +/- 3.19, with 70.2% of participants reporting poor sleep quality. The mean physical and mental component scores were 42.6 +/- 7.98 and 38.9 +/- 8.03, respectively. Hierarchical multiple regression analyses indicated that after controlling for demographic characteristics, chronic disease, and body mass index, sleep-related variables significantly predicted both physical and mental health-related quality of life. The analysis showed that sleep-related factors had a substantially larger predictive contribution toward mental health (DeltaR2 = 5.7%) than toward physical health (DeltaR2 = 1.0%). In conclusion, this study revealed a high rate of poor sleep quality (70.2%) in Qassim, Saudi Arabia, with notable negative effects on mental health. Increasing awareness and integrating sleep assessments into public health initiatives are crucial for improving sleep quality. CI - Copyright: (c) 2026 Alsaud et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Alsaud, Jolan AU - Alsaud J AUID- ORCID: 0000-0003-0067-7479 AD - Qassim Health Cluster, Qassim, Saudi Arabia. FAU - Alkhalaf, Ghadi AU - Alkhalaf G AD - Patients' Friends Association, Unayzah Governorate, Qassim, Saudi Arabia. FAU - Alsaleem, Rand AU - Alsaleem R AD - Patients' Friends Association, Unayzah Governorate, Qassim, Saudi Arabia. FAU - Alqefari, Betool AU - Alqefari B AD - Patients' Friends Association, Unayzah Governorate, Qassim, Saudi Arabia. FAU - Alfozan, Haifa AU - Alfozan H AD - Patients' Friends Association, Unayzah Governorate, Qassim, Saudi Arabia. FAU - Alqaraawi, Lama AU - Alqaraawi L AUID- ORCID: 0009-0005-0067-9951 AD - Patients' Friends Association, Unayzah Governorate, Qassim, Saudi Arabia. FAU - Wali, Siraj AU - Wali S AD - King Abdulaziz University, Jeddah, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260806 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - *Quality of Life MH - Female MH - *Sleep Wake Disorders/epidemiology MH - Male MH - Adult MH - Cross-Sectional Studies MH - Prevalence MH - Middle Aged MH - Sleep Quality MH - Young Adult MH - Surveys and Questionnaires MH - Adolescent PMC - PMC13446683 COIS- The authors have declared that no competing interests exist. EDAT- 2026/08/06 18:35 MHDA- 2026/08/06 18:36 PMCR- 2026/08/06 CRDT- 2026/08/06 13:45 PHST- 2025/10/22 00:00 [received] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/08/06 18:36 [medline] PHST- 2026/08/06 18:35 [pubmed] PHST- 2026/08/06 13:45 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - PONE-D-25-50621 [pii] AID - 10.1371/journal.pone.0347188 [doi] PST - epublish SO - PLoS One. 2026 Aug 6;21(8):e0347188. doi: 10.1371/journal.pone.0347188. eCollection 2026. PMID- 42560161 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260813 IS - 1460-2245 (Electronic) IS - 0957-4824 (Print) IS - 0957-4824 (Linking) VI - 41 IP - 4 DP - 2026 Jul 1 TI - The feasibility of the COMMUNICATE toolkit to support the communication of physical activity messages with adolescents in Irish schools. LID - 10.1093/heapro/daag110 [doi] LID - daag110 AB - The Active School Flag (ASF) is a peer-led whole-of-school physical activity (PA) programme in Irish secondary schools. This study assessed the feasibility of implementing the COMMUNICATE toolkit for ASF programme implementers (peer leaders and coordinating teachers). A pre-post, quasi-experimental, mixed-methods design was employed and guided by the Orsmond and Cohn feasibility objectives. Online surveys, semi-structured interviews, and focus groups were collected from six secondary schools (40% recruitment rate), 170 peer leaders, and three coordinating teachers. Survey data were analysed using descriptive statistics and independent and paired samples t-tests. Interview and focus group data were analysed using a combined inductive-deductive reflexive thematic analysis. Data were integrated during the writing-up stage. The toolkit was acceptable and appropriate; however, full implementation was hindered by time constraints within the busy school schedule and short implementation period. Methodological refinements regarding data collection timing and instrument validity and reliability were identified as necessary. Despite no differences between the intervention and control groups' communication skills or health knowledge at follow-up, the toolkit positively impacted peer leaders' personal development and knowledge and the PA and knowledge levels of their peers. While a real-world implementation design, led by programme implementers, may improve intervention sustainability and cost efficiency, implementation support and flexibility in delivery are essential. The COMMUNICATE toolkit was a valuable resource for whole-of-school programme implementers. Nevertheless, changes to the intervention and study procedures are required before proceeding to a definitive trial. Future research should consider an internal pilot within a definitive trial to ensure the changes are sufficient. CI - (c) The Author(s) 2026. Published by Oxford University Press. FAU - Grady, Caera L AU - Grady CL AUID- ORCID: 0000-0002-9411-9066 AD - School of Sport and Human Performance, Faculty of Science and Health, Dublin City University, Dublin, Ireland. FAU - Murtagh, Elaine AU - Murtagh E AD - Physical Activity for Health Research Centre, Health Research Institute, University of Limerick, Limerick, Ireland. AD - Department of Physical Education and Sport Sciences, Faculty of Education and Health Sciences, University of Limerick, Limerick, Ireland. FAU - Ng, Kwok AU - Ng K AD - Physical Activity for Health Research Centre, Health Research Institute, University of Limerick, Limerick, Ireland. AD - Department of Physical Education and Sport Sciences, Faculty of Education and Health Sciences, University of Limerick, Limerick, Ireland. AD - Department of Teacher Education, Turku Institute for Advanced Studies, University of Turku, Turku, Finland. AD - Institute of Sports Science and Innovation, Lithuanian Sport University, Kaunas, Lithuania. FAU - Garcia Bengoechea, Enrique AU - Garcia Bengoechea E AD - Physical Activity for Health Research Centre, Health Research Institute, University of Limerick, Limerick, Ireland. AD - Department of Physical Education and Sport Sciences, Faculty of Education and Health Sciences, University of Limerick, Limerick, Ireland. FAU - Woods, Catherine B AU - Woods CB AD - Physical Activity for Health Research Centre, Health Research Institute, University of Limerick, Limerick, Ireland. AD - Department of Physical Education and Sport Sciences, Faculty of Education and Health Sciences, University of Limerick, Limerick, Ireland. LA - eng GR - Taighde Eireann/ GR - GOIPG/2022/78/Research Ireland Government of Ireland Postgraduate Scholarship/ PT - Journal Article PL - England TA - Health Promot Int JT - Health promotion international JID - 9008939 SB - IM MH - Humans MH - Ireland MH - Peer Group MH - Feasibility Studies MH - *Health Promotion/methods/organization & administration MH - *Exercise MH - Adolescent MH - *Schools MH - *Communication MH - Focus Groups MH - *School Health Services/organization & administration MH - Female MH - Surveys and Questionnaires PMC - PMC13445620 OTO - NOTNLM OT - acceptability OT - adolescents OT - appropriateness OT - health literacy OT - messages COIS- The authors have no conflicts of interest to declare. EDAT- 2026/08/06 12:37 MHDA- 2026/08/06 12:38 PMCR- 2026/08/06 CRDT- 2026/08/06 09:53 PHST- 2026/08/06 12:38 [medline] PHST- 2026/08/06 12:37 [pubmed] PHST- 2026/08/06 09:53 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 8753138 [pii] AID - daag110 [pii] AID - 10.1093/heapro/daag110 [doi] PST - ppublish SO - Health Promot Int. 2026 Jul 1;41(4):daag110. doi: 10.1093/heapro/daag110. PMID- 42559030 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260927 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 15 DP - 2026 TI - Parental perspectives concerning gluten-free food insecurity in households with children with coeliac disease: take away messages for policy makers. PG - e69 LID - 10.1017/jns.2026.10131 [doi] LID - e69 AB - Coeliac disease (CD) is an autoimmune disease resulting in lifelong intolerance to gluten. Treatment of CD is a gluten-free diet (GFD). High gluten-free (GF) food costs contribute to GF-food insecurity (GF-FI) in households with children with CD. The study objective was to describe parental perceptions of the barriers/facilitators of GF-food security (GF-FS) and the health policies parents deem necessary to combat GF-FI. A subset analysis of a cross-sectional study examining household and child socio-demographic, child diet quality and GFD adherence, food environment, and GF-FI in parent-child dyads (n = 59) using validated questionnaires. Virtual interviews included 13 open-and-closed ended questions examining parent perceptions related to barriers/facilitators of GF-FS and health policies to address GF-FI. Questions were validated for face-and-content using an iterative process with parental responses deductively coded using the 5As of food insecurity theoretical framework. High GF-food costs (>90%) and the lack of effective GF-food specific health policies ( approximately 94%) were the most commonly cited barriers to GF-FS, particularly in GF-FI households. Social media (>60%) was used to share information related to tax credits (15%) affordability, accessibility, and availability of GF-foods (75%). Parents deemed child tax credits ( approximately 75%), development of food policies focused on education in schools ( approximately 34%), dietary prescriptions (25%) and official recognition of CD as a disability ( approximately 26%) as important to address GF-FI. In conclusion, parents perceive high GF-food costs and lack of effective GF-food health policies as important mediators of GF-FI. Social media platforms were widely used by the community to share information and solutions to address GF-FI. CI - (c) The Author(s) 2026. FAU - Mager, Diana R AU - Mager DR AUID- ORCID: 0000-0002-5558-8783 AD - Department of Agricultural, Food and Nutritional Sciences, Faculty of Agricultural, Food & Environmental Science, University of Alberta, Canada. ROR: https://ror.org/0160cpw27 AD - Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Canada. FAU - Anders, Sven AU - Anders S AD - Department of Resource Economics & Environmental Sociology, Faculty of Agricultural, Life and Environmental Science, University of Alberta, Canada. FAU - Bruce, Marcia AU - Bruce M AD - Faculty of Medicine, University of Calgary, Canada. FAU - Turner, Justine M AU - Turner JM AD - Department of Agricultural, Food and Nutritional Sciences, Faculty of Agricultural, Food & Environmental Science, University of Alberta, Canada. ROR: https://ror.org/0160cpw27 AD - Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Canada. LA - eng PT - Journal Article DEP - 20260730 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 SB - IM MH - Humans MH - *Celiac Disease/diet therapy MH - *Diet, Gluten-Free/economics MH - *Food Insecurity MH - Cross-Sectional Studies MH - Child MH - Female MH - Male MH - *Parents/psychology MH - Surveys and Questionnaires MH - Adult MH - Child, Preschool MH - Family Characteristics MH - Adolescent MH - Health Policy MH - *Food Supply PMC - PMC13439013 OTO - NOTNLM OT - Caregiver perspectives OT - Food insecurity OT - Gluten-free diet OT - Policy OT - social media COIS- The authors declare none. EDAT- 2026/08/06 12:37 MHDA- 2026/08/06 12:38 PMCR- 2026/07/30 CRDT- 2026/08/06 06:48 PHST- 2025/08/13 00:00 [received] PHST- 2026/05/11 00:00 [revised] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/08/06 12:38 [medline] PHST- 2026/08/06 12:37 [pubmed] PHST- 2026/08/06 06:48 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - S2048679026101311 [pii] AID - 10.1017/jns.2026.10131 [doi] PST - epublish SO - J Nutr Sci. 2026 Jul 30;15:e69. doi: 10.1017/jns.2026.10131. eCollection 2026. PMID- 42557588 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260813 IS - 1750-1172 (Electronic) IS - 1750-1172 (Linking) VI - 21 IP - 1 DP - 2026 Aug 6 TI - Assessment of cardiometabolic risk using single point insulin sensitivity estimator (SPISE) in pediatric Bardet-Biedl Syndrome: a pilot study. LID - 10.1186/s13023-026-04353-y [doi] LID - 266 AB - BACKGROUND: Bardet-Biedl syndrome (BBS) carries early cardiometabolic risk, yet pediatric screening is complicated by growth and puberty. The metabolic syndrome (MetS) z-score provides a continuous benchmark for clustered risk. The single-point insulin sensitivity estimator (SPISE), based on body mass index (BMI) and fasting lipids, may offer a practical alternative where insulin testing is impractical. We aimed to assess the association between SPISE and cardiometabolic burden in children with molecularly confirmed BBS, and to compare its ability to identify MetS against the MetS z-score benchmark and insulin-derived indices. METHODS: Single-center retrospective pilot study including children/adolescents with genetically confirmed BBS who underwent standardized anthropometry and metabolic profiling (fasting lipids, glucose, insulin; OGTT when available). SPISE-MetS z-score associations were examined using Spearman and adjusted analyses. In adolescents (>/= 10 years), MetS discrimination was evaluated with ROC curves for SPISE, TG/HDL, and homeostatic model assessment for insulin resistance (HOMA-IR), with pairwise DeLong comparisons and Youden-optimal thresholds. RESULTS: Fourteen participants (7 females, 7 males) were evaluated. Median age at last visit was 11.7 years [IQR 7.6-15.5]; BMI SDS was 3.05 [2.47-3.57]. The median MetS z-score was 1.60 [0.90-1.75]. SPISE correlated inversely with the MetS z-score (rho=-0.57, p = 0.021), and adjusted models (age, sex, BMI-SDS) retained significance. Among adolescents (n = 10), SPISE showed the highest AUC for MetS (AUC 0.95; 95% CI 0.82-1.00) versus TG/HDL (AUC 0.81) and HOMA-IR (AUC 0.60); pairwise differences were not statistically significant. Youden-optimal SPISE 0.05). Stroke index and swimming speed (real and synthetic) showed moderate to very strong associations with 1500 m time in both male (r = -0.53 to -0.76) and female swimmers (r = -0.54 to -0.97). In the male model, performance is primarily driven by variables related to stroke efficiency, maximal oxygen uptake, and high-intensity physiological strain. The female model places greater emphasis on pacing-related variables, including mean swimming speed during endurance and [La(-)] tolerance tests, anaerobic threshold velocity, and metabolic stress indicators. Symbolic regression applied to synthetic datasets is suitable to address the small sample size limitations often present in human research, particularly swimming. Coaches and researchers are encouraged to use symbolic regression and synthetic data and to report the resulting equations to support mechanistic interpretation of 1500 m performance prediction equations for male and female swimmers. FAU - Chainok, Phornpot AU - Chainok P AUID- ORCID: 0000-0003-2605-4181 AD - Faculty of Sport Science, Burapha University, Thailand. FAU - Matjiur, Radomyos AU - Matjiur R AUID- ORCID: 0009-0000-9835-6192 AD - Faculty of Sport Science, Burapha University, Thailand. FAU - de Jesus, Karla AU - de Jesus K AUID- ORCID: 0000-0002-7710-9843 AD - Human Performance Laboratory, Faculty of Physical Education and Physiotherapy, Federal University of Amazonas, Brazil. FAU - Dos Santos Coelho, Leandro AU - Dos Santos Coelho L AUID- ORCID: 0000-0001-5728-943X AD - Department of Electrical Engineering, Federal University of Parana, Parana, Brazil. FAU - Cocco Mariani, Viviana AU - Cocco Mariani V AUID- ORCID: 0000-0003-2490-4568 AD - Department of Electrical Engineering, Federal University of Parana, Parana, Brazil. AD - Mechanical Engineering Graduate Program, Federal University of Parana, Parana, Brazil. FAU - Zacca, Rodrigo AU - Zacca R AUID- ORCID: 0000-0003-0494-0000 AD - Research Center in Physical Activity, Health and Leisure (CIAFEL), Faculty of Sport, University of Porto (FADEUP), Porto, Portugal. AD - Laboratory for Integrative and Translational Research in Population Health (ITR), Porto, Portugal. AD - Nucleus of Research in Human Motricity Sciences, Universidad Adventista de Chile, Chillan, Chile. AD - Laboratory of Sport Physiology, Faculty of Sports, University of Porto, Porto, Portugal. FAU - Fernandes, Ricardo J AU - Fernandes RJ AUID- ORCID: 0000-0002-5811-0443 AD - Centre for Research, Education, Innovation and Intervention in Sport (CIFI2D), Faculty of Sport (FADEUP), University of Porto, Porto, Portugal. AD - Porto Biomechanics Laboratory (LABIOMEP), University of Porto, Porto, Portugal. FAU - Vilas-Boas, Joao Paulo AU - Vilas-Boas JP AUID- ORCID: 0000-0002-4109-2939 AD - Centre for Research, Education, Innovation and Intervention in Sport (CIFI2D), Faculty of Sport (FADEUP), University of Porto, Porto, Portugal. AD - Porto Biomechanics Laboratory (LABIOMEP), University of Porto, Porto, Portugal. LA - eng PT - Journal Article DEP - 20260805 PL - England TA - J Sports Sci JT - Journal of sports sciences JID - 8405364 SB - IM MH - Humans MH - *Swimming/physiology MH - Female MH - *Athletic Performance/physiology MH - Male MH - Biomechanical Phenomena MH - Oxygen Consumption/physiology MH - Adolescent MH - Body Composition MH - Regression Analysis MH - Physical Endurance/physiology MH - Anaerobic Threshold/physiology MH - Anthropometry MH - Stress, Physiological OTO - NOTNLM OT - Biomechanics OT - Exercise physiology OT - Interpretable machine learning OT - Long-Distance Events OT - Sports analytics OT - Swimming OT - Symbolic learning OT - interpretability OT - modelling EDAT- 2026/08/05 13:37 MHDA- 2026/08/28 11:49 CRDT- 2026/08/05 08:13 PHST- 2026/08/28 11:49 [medline] PHST- 2026/08/05 13:37 [pubmed] PHST- 2026/08/05 08:13 [entrez] AID - 10.1080/02640414.2026.2710467 [doi] PST - ppublish SO - J Sports Sci. 2026 Aug;44(16):2065-2082. doi: 10.1080/02640414.2026.2710467. Epub 2026 Aug 5. PMID- 42554309 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261015 IS - 1440-1754 (Electronic) IS - 1034-4810 (Linking) VI - 62 IP - 10 DP - 2026 Oct TI - The Performance of the STRONGkids Nutrition Screening Tool Following Nurse Training in a Tertiary Care Setting. PG - 1894-1900 LID - 10.1111/jpc.70515 [doi] AB - AIM: The low sensitivity of STRONGkids, a nutrition risk screening tool, was observed during its implementation in patient care services at a tertiary care hospital. The screening process improvement was performed to enhance its effectiveness. This study aimed to evaluate the validity and inter-rater reliability of the screening tool after the improvement process. METHODS: This was a cross-sectional study that collected baseline characteristics and clinical data from medical records. STRONGkids score and risk classification were recorded by ward nurses. Concurrent validity was assessed with respect to nutritional status, including undernutrition (BMI Z-score < -2), stunting (height-for-age Z-score < -2), and overall malnutrition (including both undernutrition and stunting). Nutrition risk screening was repeated by a nutrition nurse to determine inter-rater reliability. RESULTS: The study enrolled 1419 paediatric admissions. Undernutrition, stunting, and overall malnutrition were observed in 13%, 17%, and 27.6% of participants, respectively. STRONGkids classified 24%, 71.1%, and 4.9% of patients as having low, moderate, and high nutrition risk, respectively. Patients with high nutrition risk had significantly longer hospital stays and higher rates of hospital-acquired infections. STRONGkids demonstrated sensitivities of 82.4%-82.6% and specificities of 25%-26.5% for nutrition status. Inter-rater reliability was assessed across 320 admissions and showed excellent reliability for both the total score (k = 0.84; p < 0.001) and risk categories (k = 0.89; p < 0.001). CONCLUSION: The performance of the nutrition risk screening tool may differ from that observed in research settings when used in routine clinical practice. STRONGkids demonstrates satisfactory validity and inter-rater reliability after the improvement process. CI - (c) 2026 Paediatrics and Child Health Division (The Royal Australasian College of Physicians). FAU - Ngamboriruk, Punthita AU - Ngamboriruk P AD - Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. FAU - Dumrongwongsiri, Oraporn AU - Dumrongwongsiri O AD - Division of Nutrition, Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. FAU - Phoonlapdacha, Phanphen AU - Phoonlapdacha P AD - Division of Nutrition, Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. LA - eng PT - Journal Article DEP - 20260805 PL - Australia TA - J Paediatr Child Health JT - Journal of paediatrics and child health JID - 9005421 SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Nutrition Assessment MH - Reproducibility of Results MH - Female MH - Tertiary Care Centers MH - *Mass Screening/methods MH - Male MH - *Malnutrition/diagnosis MH - Child, Preschool MH - Nutritional Status MH - Infant MH - Sensitivity and Specificity MH - *Child Nutrition Disorders/diagnosis OTO - NOTNLM OT - STRONGkids OT - hospitalised children OT - malnutrition OT - nutritional screening EDAT- 2026/08/05 13:37 MHDA- 2026/10/15 23:30 CRDT- 2026/08/05 07:53 PHST- 2026/06/28 00:00 [revised] PHST- 2026/04/28 00:00 [received] PHST- 2026/07/17 00:00 [accepted] PHST- 2026/10/15 23:30 [medline] PHST- 2026/08/05 13:37 [pubmed] PHST- 2026/08/05 07:53 [entrez] AID - 10.1111/jpc.70515 [doi] PST - ppublish SO - J Paediatr Child Health. 2026 Oct;62(10):1894-1900. doi: 10.1111/jpc.70515. Epub 2026 Aug 5. PMID- 42553102 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260805 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Associations between early childhood appetitive traits and dietary diversity in school-age children: a two-year longitudinal follow-up study. PG - 1824771 LID - 10.3389/fnut.2026.1824771 [doi] LID - 1824771 AB - BACKGROUND: Dietary diversity reflects diet quality and is critical for children's growth and long-term health. Appetitive traits affect dietary habits and long-term food choices. However, few studies have explored the associations between early childhood appetitive traits and dietary diversity in school-age children using standardized and validated tools. METHODS: We recruited 208 kindergarten children aged 5-6 years, with 194 completing the two-year longitudinal follow-up. Appetitive traits were evaluated at age 5-6 using the Child Eating Behavior Questionnaire (CEBQ). Dietary diversity was assessed 2 years later via the Dietary Diversity Score (DDS). Binary logistic regressions were carried out to assess the associations between early childhood appetitive traits and dietary diversity. Inverse probability weighting (IPW) was conducted in complete cases to test the robustness of the main results. RESULTS: Higher food fussiness at 5-6 years was significantly associated with a lower likelihood of high DDS 2 years later (OR = 0.521, 95% CI: 0.327-0.830). No significant sex interactions were observed for these associations. CONCLUSION: Food fussiness at 5-6 years was associated with dietary diversity in school-age children. These findings underscore the relevance of early appetitive traits to dietary diversity and provide evidence-based insights for promoting children's nutrition. CI - Copyright (c) 2026 Mu, Bu, Xu, Yuan, Dai, Lv, Liu, Tang, Zhang and Jin. FAU - Mu, Yuhong AU - Mu Y AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Bu, Duhan AU - Bu D AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Xu, Xiaowen AU - Xu X AD - Department of Endocrinology, Children's Hospital of Soochow University, Suzhou, China. FAU - Yuan, Jing AU - Yuan J AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Dai, Xinxin AU - Dai X AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Lv, Weiqing AU - Lv W AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Liu, Yan AU - Liu Y AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Tang, Jiachen AU - Tang J AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Zhang, Libing AU - Zhang L AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Jin, Yu AU - Jin Y AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. LA - eng PT - Journal Article DEP - 20260721 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13433194 OTO - NOTNLM OT - appetitive traits OT - child eating behavior questionnaire OT - children OT - dietary diversity OT - dietary diversity score COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/05 06:42 MHDA- 2026/08/05 06:43 PMCR- 2026/07/21 CRDT- 2026/08/05 04:42 PHST- 2026/03/06 00:00 [received] PHST- 2026/07/02 00:00 [revised] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/08/05 06:43 [medline] PHST- 2026/08/05 06:42 [pubmed] PHST- 2026/08/05 04:42 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - 10.3389/fnut.2026.1824771 [doi] PST - epublish SO - Front Nutr. 2026 Jul 21;13:1824771. doi: 10.3389/fnut.2026.1824771. eCollection 2026. PMID- 42552914 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260805 LR - 20260813 IS - 2287-3732 (Print) IS - 2287-3740 (Electronic) IS - 2287-3732 (Linking) VI - 15 IP - 3 DP - 2026 Jul TI - Discrepancies between preschoolers' self-perceived healthy eating practices and parental assessments: a cross-sectional study in South Korea. PG - 184-190 LID - 10.7762/cnr.2026.0009 [doi] AB - OBJECTIVE: Although healthy dietary habits established in early childhood are critical for lifelong health, most previous studies have relied predominantly on parental proxy reports rather than children's self-perceptions. This study compared preschoolers' self-perceived healthy dietary practices with their parents' evaluations and examined discrepancies between them. METHODS: This study included 243 preschoolers aged 2 to 7 years and their parents, recruited from daycare centers in Cheonan, South Korea. Data were collected using the validated, structured, self-administered Healthy Eating Practice Questionnaire, which assessed nutrition and hygiene. Mean Healthy Eating Practice Scores were compared between preschoolers and their parents using paired t-tests, and stratified analyses were conducted by sex and age. RESULTS: Preschoolers rated their healthy dietary practices significantly higher than their parents did (P<0.001). The discrepancy was greater for nutrition than for hygiene, with hygiene ratings more consistent. This domain-specific pattern was consistent across sexes and age groups. When stratified by sex and age, preschooler-parent Healthy Eating Practice Score differences were significantly higher in boys than in girls (25.0+/-21.0 vs. 20.0+/-14.9, respectively; P=0.035). CONCLUSION: Discrepancies between preschoolers' self-perceptions and their parents' evaluations suggest that incorporating both perspectives is essential for accurately assessing children's dietary practices. These findings support the development of dual-perspective dietary assessment and education strategies in early childhood. FAU - An, Jiwon AU - An J AD - Department of Food Science and Nutrition, Dankook University, Cheonan, Korea. FAU - Lee, Seulgi AU - Lee S AD - Department of Food Science and Nutrition, Dankook University, Cheonan, Korea. FAU - Kim, Kirang AU - Kim K AD - Department of Food Science and Nutrition, Dankook University, Cheonan, Korea. LA - eng PT - Journal Article DEP - 20260731 PL - Korea (South) TA - Clin Nutr Res JT - Clinical nutrition research JID - 101592483 PMC - PMC13447742 OTO - NOTNLM OT - Eating behavior OT - Parents OT - Perception OT - Preschool COIS- Conflict of Interest None. EDAT- 2026/08/05 06:42 MHDA- 2026/08/05 06:43 PMCR- 2026/07/31 CRDT- 2026/08/05 03:35 PHST- 2026/03/11 00:00 [received] PHST- 2026/07/11 00:00 [accepted] PHST- 2026/08/05 06:43 [medline] PHST- 2026/08/05 06:42 [pubmed] PHST- 2026/08/05 03:35 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - cnr.2026.0009 [pii] AID - cnr-2026-0009 [pii] AID - 10.7762/cnr.2026.0009 [doi] PST - ppublish SO - Clin Nutr Res. 2026 Jul;15(3):184-190. doi: 10.7762/cnr.2026.0009. Epub 2026 Jul 31. PMID- 42550031 OWN - NLM STAT- MEDLINE DCOM- 20260804 LR - 20260813 IS - 1520-6300 (Electronic) IS - 1042-0533 (Print) IS - 1042-0533 (Linking) VI - 38 IP - 8 DP - 2026 Aug TI - Associations Between Motor Competence, Health-Related Physical Fitness, and Mental Health Outcomes in Spanish Adolescents: The ENERGYCO Study. PG - e70318 LID - 10.1002/ajhb.70318 [doi] LID - e70318 AB - BACKGROUND: Motor competence (MC) has been proposed as an important correlate of physical and mental health during youth. However, evidence examining its associations with both health-related physical fitness and mental health in Spanish adolescents remains limited. OBJECTIVE: To examine the associations between objectively assessed MC and health-related physical fitness and mental health in Spanish adolescents. METHODS: This cross-sectional study included 273 adolescents (46.9% girls; 12-17 years). MC was assessed using the Bruininks-Oseretsky Test of Motor Proficiency Short Form (BOT-2 SF). Anthropometric measures, physical fitness, and mental health were assessed using validated protocols and questionnaires. Two-level linear mixed-effects and generalized estimating equation logistic regression models were adjusted for sex, biological maturation, socioeconomic status, and self-reported physical activity. RESULTS: Higher MC was consistently associated with more favorable health-related physical fitness outcomes (all p < 0.001) and with a greater likelihood of meeting established health-related physical fitness criteria. MC was inversely associated with waist-to-height ratio (p = 0.028), whereas no consistent associations were observed with other anthropometric measures or mental health outcomes. CONCLUSION: Higher MC was consistently associated with health-related physical fitness in Spanish adolescents, whereas associations with anthropometric measures and mental health were limited. Future adequately powered longitudinal and intervention studies are warranted to clarify the directionality of these relationships. CI - (c) 2026 Wiley Periodicals LLC. FAU - Valle-Munoz, Victor Manuel AU - Valle-Munoz VM AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. FAU - Avila-Garcia, Manuel AU - Avila-Garcia M AD - Inmaculada Teacher Training Centre, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. AD - Faculty of Sport Sciences, Universidad Isabel I, Burgos, Spain. FAU - Campos-Garzon, Pablo AU - Campos-Garzon P AD - SPORT Research Group (CTS-1024), CIBIS (Centro de Investigacion Para el Bienestar y la Inclusion Social) Research Center, University of Almeria, Almeria, Spain. AD - Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. FAU - Perez De Arrilucea Le Floc'h, Unai A AU - Perez De Arrilucea Le Floc'h UA AD - Faculty of Sport Sciences, Universidad Isabel I, Burgos, Spain. AD - Faculty of Health Sciences, Universidad Europea de Valencia, Valencia, Spain. FAU - Estevan, Isaac AU - Estevan I AD - AFIPS Research Group, Department of Teaching of Physical Education, Arts and Music, University of Valencia, Valencia, Spain. FAU - Villa-Gonzalez, Emilio AU - Villa-Gonzalez E AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. LA - eng GR - FPU23/01608/V.M.V.-M.: FPU Predoctoral Research Fellowship from the Spanish Ministry of Universities/ GR - PID2021-126126OA-I00/Spanish Ministry of Science and Innovation (MCIN) and the State Research Agency/ GR - BG24/00004/P.C.-G.: Spanish Ministry of Universities/ GR - PRX24/00031/I.-E.: Spanish Ministry of Science, Innovation and Universities (Gobierno de Espana)/ PT - Journal Article PL - United States TA - Am J Hum Biol JT - American journal of human biology : the official journal of the Human Biology Council JID - 8915029 SB - IM MH - Humans MH - *Physical Fitness MH - Spain MH - Female MH - *Mental Health/statistics & numerical data MH - Cross-Sectional Studies MH - Adolescent MH - *Motor Skills MH - Male MH - Child PMC - PMC13436258 OTO - NOTNLM OT - adolescence OT - gross motor skills OT - health OT - physical education COIS- The authors declare no conflicts of interest. EDAT- 2026/08/04 12:46 MHDA- 2026/08/04 12:47 PMCR- 2026/08/04 CRDT- 2026/08/04 10:03 PHST- 2026/07/01 00:00 [revised] PHST- 2026/04/10 00:00 [received] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/08/04 12:47 [medline] PHST- 2026/08/04 12:46 [pubmed] PHST- 2026/08/04 10:03 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - AJHB70318 [pii] AID - 10.1002/ajhb.70318 [doi] PST - ppublish SO - Am J Hum Biol. 2026 Aug;38(8):e70318. doi: 10.1002/ajhb.70318. PMID- 42549391 OWN - NLM STAT- MEDLINE DCOM- 20260804 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Artificial intelligence in nutritional health: sustainable consumers' right to quality of life with special reference to youth. PG - 1817284 LID - 10.3389/fpubh.2026.1817284 [doi] LID - 1817284 AB - BACKGROUND: Maintaining optimal youth nutritional health is an urgent socio-economic imperative that underpins long-term human productivity and rights-based development. However, modern youth cohorts face unique dietary threats caused by the widespread availability of ultra-processed foods, targeted digital marketing, and complex food labeling protocols. Although Artificial Intelligence (AI) presents innovative avenues for personalized dietary profiling, existing systems remain largely technocentric and detached from statutory frameworks or behavioral realities. OBJECTIVE: This study bridges this interdisciplinary divide by evaluating a rights-based, technology-driven framework to improve youth nutritional health. It aims to: (1) empirically evaluate the "Knowledge-Attitude-Practice" (KAP) gap linking statutory consumer rights to real-world eating habits; (2) present the engineering design of a non-commercial Progressive Web Application (PWA) built to translate legal safeguards into daily behavioral changes; and (3) triangulate these findings using data from youth surveys and expert legal and nutritional panels. METHODS: Using a cross-sectional approach based on non-parametric power constraints, a validated survey instrument was completed by a target sample of Indian youth (n = 354, aged 15-25 years). Concurrently, data matrices were compiled from regional legal experts (n = 12) and public nutrition professionals (n = 12) to cross-verify structural bottlenecks. Group variances, demographic dependencies, and rank associations were analyzed using robust non-parametric tests, including One-Way ANOVA, Kruskal-Wallis (H), Welch's t-test, and Kendall's Tau (tau) correlation coefficients. RESULTS: Inferential analysis revealed unexpected demographic trends: undergraduate status predicted significantly higher FSSAI safety awareness than post-graduate status (p = 0.0037), while subjective health ratings exhibited a non-linear relationship with household income (p = 0.0004), peaking in the lower-middle financial tier. Crucially, rank correlation testing revealed that the relationship between statutory knowledge and actual dietary actions is functionally non-existent (tau = -0.001). This near-zero correlation provides clear empirical proof of a pronounced Knowledge-Action Gap, confirming that passive legal literacy fails to influence food selection in modern environments. CONCLUSION: By framing automated behavioral interventions within the constitutional protections of Article 21 of the Constitution of India and the Consumer Protection Act, 2019, this study shows how the open-access PWA (nutrition-zb.pages.dev) can bridge this behavioral gap. This shifts the focus of consumer health informatics from basic self-tracking to a rights-based, systemic public health intervention. CI - Copyright (c) 2026 Indirapriyadarsini, Guttapalam, Mogarala and Guptha. FAU - Indirapriyadarsini, G AU - Indirapriyadarsini G AD - Department of Law, Sri Padmavati Mahila Visvavidyalayam (Women's University), Tirupati, Andhra Pradesh, India. FAU - Guttapalam, Sireesha AU - Guttapalam S AD - Department of Home Science, Sri Padmavati Mahila Visvavidyalayam (Women's University), Tirupati, Andhra Pradesh, India. FAU - Mogarala, Ramyasri AU - Mogarala R AD - Department of Research and Development Cell, Sri Padmavati Mahila Visvavidyalayam (Women's University), Tirupati, Andhra Pradesh, India. FAU - Guptha, Kalpeshkumar L AU - Guptha KL AD - Former Faculty, Gujarat National Law University, Surat, Gujarat, India. LA - eng PT - Journal Article DEP - 20260720 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Adolescent MH - *Artificial Intelligence MH - Female MH - Cross-Sectional Studies MH - Male MH - Young Adult MH - *Quality of Life MH - Adult MH - India MH - *Health Knowledge, Attitudes, Practice MH - *Feeding Behavior MH - Surveys and Questionnaires PMC - PMC13431161 OTO - NOTNLM OT - artificial intelligence OT - consumer protection OT - food safety regulations OT - knowledge-attitude-practice (KAP) gap OT - progressive web application (PWA) OT - sustainable development goals OT - sustainable health OT - youth health COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/04 12:46 MHDA- 2026/08/04 12:47 PMCR- 2026/07/20 CRDT- 2026/08/04 06:34 PHST- 2026/02/25 00:00 [received] PHST- 2026/06/11 00:00 [revised] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/08/04 12:47 [medline] PHST- 2026/08/04 12:46 [pubmed] PHST- 2026/08/04 06:34 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1817284 [doi] PST - epublish SO - Front Public Health. 2026 Jul 20;14:1817284. doi: 10.3389/fpubh.2026.1817284. eCollection 2026. PMID- 42548181 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261014 IS - 2092-7193 (Electronic) IS - 2092-7193 (Linking) VI - 48 DP - 2026 TI - Device-related differences in blood pressure measurement and their impact on hypertension prevalence in Korean children and adolescents. PG - e2026037 LID - 10.4178/epih.e2026037 [doi] AB - OBJECTIVES: Accurate blood pressure (BP) measurement is essential for reliably estimating hypertension prevalence in population-based surveys. However, evidence supporting the use of oscillometric BP devices in pediatric populations remains limited. This study compared BP measurements obtained using an oscillometric device (OD) and an auscultatory device (AD) and evaluated inter-device agreement and the impact of device choice on hypertension prevalence estimates. METHODS: BP was measured sequentially with the AD and OD in 251 children and adolescents participating in the Korea National Health and Nutrition Examination Survey. Inter-device agreement was assessed using mean differences, limits of agreement, concordance correlation coefficients (CCCs), and regression analyses. Differences in prevalence estimates for elevated blood pressure (EBP) and hypertension were also examined. RESULTS: Mean inter-device differences were minimal for systolic blood pressure (SBP; 0.2+/-5.9 mmHg) but negative for diastolic blood pressure (DBP; -1.5+/-6.1 mmHg), with larger discrepancies in older girls. Agreement was moderate to good for SBP (CCC=0.79) and weaker for DBP (CCC=0.60). Nevertheless, more than 85% of paired measurements were within +/-10 mmHg. Prevalence estimates for EBP (11.6 vs. 10.0%) and hypertension (4.8 vs. 4.4%) were comparable between devices, with relatively high negative agreement and overall agreement. CONCLUSIONS: Despite modest underestimation of DBP in specific subgroups, oscillometric BP measurement showed acceptable agreement with the auscultatory method and yielded similar hypertension prevalence estimates. These findings suggest that ODs may be useful for pediatric BP measurement in public health surveillance systems. FAU - Kim, Sung Hye AU - Kim SH AD - Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea. FAU - Kim, Yu-Mi AU - Kim YM AD - Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea. AD - Institute for Health and Society, Hanyang University, Seoul, Korea. FAU - Kim, Hack-Lyoung AU - Kim HL AD - Department of Internal Medicine, Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea. FAU - Park, Sang Min AU - Park SM AD - Division of Cardiology, Department of Internal Medicine, Nowon Eulji Medical Center, Eulji University College of Medicine, Seoul, Korea. FAU - Cho, In-Jeong AU - Cho IJ AD - Division of Cardiology, Department of Internal Medicine, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea. FAU - Kim, Dae-Hee AU - Kim DH AD - Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. FAU - Kim, Kwang-Il AU - Kim KI AD - Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea. FAU - Shin, Jinho AU - Shin J AD - Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. FAU - Oh, Kyungwon AU - Oh K AD - Division of Health and Nutrition Survey and Analysis, Bureau of Chronic Disease Prevention and Control, Korea Disease Control and Prevention Agency, Cheongju, Korea. FAU - Lee, Eun Mi AU - Lee EM AD - Division of Cardiology, Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, Korea. mdemlee@naver.com. LA - eng PT - Journal Article DEP - 20260727 PL - Korea (South) TA - Epidemiol Health JT - Epidemiology and health JID - 101519472 SB - IM MH - Humans MH - Female MH - *Hypertension/epidemiology/diagnosis MH - Adolescent MH - Republic of Korea/epidemiology MH - Male MH - Child MH - *Blood Pressure Determination/instrumentation/methods MH - Prevalence MH - Oscillometry/instrumentation MH - Nutrition Surveys OTO - NOTNLM OT - Adolescent OT - Blood pressure OT - Blood pressure determination OT - Child OT - Hypertension OT - Oscillometry EDAT- 2026/08/04 06:37 MHDA- 2026/10/14 23:31 CRDT- 2026/08/04 03:09 PHST- 2026/04/16 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/10/14 23:31 [medline] PHST- 2026/08/04 06:37 [pubmed] PHST- 2026/08/04 03:09 [entrez] AID - epih.e2026037 [pii] AID - 10.4178/epih.e2026037 [doi] PST - ppublish SO - Epidemiol Health. 2026;48:e2026037. doi: 10.4178/epih.e2026037. Epub 2026 Jul 27. PMID- 42547597 OWN - NLM STAT- MEDLINE DCOM- 20261026 LR - 20261026 IS - 1432-5241 (Electronic) IS - 0364-216X (Linking) VI - 50 IP - 19 DP - 2026 Oct TI - The Golden Triangle Method: A Novel Simulation Framework for Rhinoplasty Design. PG - 7905-7919 LID - 10.1007/s00266-026-06197-0 [doi] AB - BACKGROUND: Current rhinoplasty simulation relies on subjective landmark planning and compartmentalized parameter analysis, resulting in inconsistent designs. This study introduces a unified geometric framework to assist in the design of harmonious noses. OBJECTIVES: To develop and provide proof-of-concept validation for a geometric framework that systematically determines optimal nasal landmark positions based on facial proportions, and to evaluate its aesthetic acceptability. METHODS: This prospective study included 30 young Turkish women (aged 18-30 years) seeking primary rhinoplasty, evaluated by 20 board-certified plastic surgeons (17 included in Visual Analog Scales analysis after outlier exclusion) and the patients themselves. The Golden Triangle method employs a 36 degrees -apex isosceles triangle to determine key nasal landmarks within a cohesive geometric framework. Simulations were created using GeoGebra (which also calculated nasal ratios and angles) and Adobe Photoshop. Evaluators rated pre- and post-simulation images using Visual Analog Scales (0-100). Technical parameters were evaluated on 5-point Likert scale by surgeons. RESULTS: Patient VAS scores increased from 41.3 +/- 10.1 to 81.9 +/- 3.3 (p < .001; Cohen's d = 5.41), and surgeon ratings improved from 34.7 +/- 6.3 to 72.6 +/- 4.4 (p < .001; Cohen's d = 7.02). The coefficient of variation decreased by 66.2% for patients' and 53.7% for surgeons' ratings, indicating improved interrater agreement on simulation images. Technical parameters reached "ideal" consensus in 93-97% of cases. Nasal ratios and angles converged toward population-specific reference values with reduced variability. CONCLUSIONS: The Golden Triangle method provides a systematic approach to rhinoplasty simulation, significantly improving aesthetic ratings and interrater agreement using affordable software. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . CI - (c) 2026. Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery. FAU - Erbayat, Yusuf AU - Erbayat Y AUID- ORCID: 0000-0003-3253-6494 AD - Department of Plastic, Reconstructive and Aesthetic Surgery, Recep Tayyip Erdogan University Teaching and Research Hospital, Islampasa Mh. Sehitler Cd. No:74 Merkez, Rize, Turkey. erbayaty@gmail.com. FAU - Kirazoglu, Ahmet AU - Kirazoglu A AD - Department of Plastic, Reconstructive and Aesthetic Surgery, Florya Hospital, Istanbul, Turkey. FAU - Yildiz, Kemalettin AU - Yildiz K AD - Department of Plastic, Reconstructive and Aesthetic Surgery, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20260803 PL - United States TA - Aesthetic Plast Surg JT - Aesthetic plastic surgery JID - 7701756 SB - IM MH - Humans MH - *Rhinoplasty/methods MH - Female MH - Adult MH - Prospective Studies MH - Young Adult MH - Adolescent MH - Esthetics MH - *Nose/anatomy & histology/surgery MH - *Computer Simulation MH - Anatomic Landmarks OTO - NOTNLM OT - Anthropometry OT - Computer simulation OT - Golden Triangle OT - Preoperative planning OT - Rhinoplasty OT - Visual Analog Scale COIS- Declarations. Conflict of interest: The corresponding author has a pending utility model application (Turkish Patent and Trademark Office, Application No: 2026/000080) for the simulation software of the Golden Triangle Method described in this study. All other authors declare that they have no conflicts of interest to disclose. Ethical Approval: This prospective observational study received approval from the University Ethics Committee on March 14, 2024 (Approval No: E-54022451-050.04-144694). All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments. Informed Consent: Informed consent was obtained from all individual participants included in the study. EDAT- 2026/08/04 00:35 MHDA- 2026/10/26 17:31 CRDT- 2026/08/03 23:52 PHST- 2026/01/22 00:00 [received] PHST- 2026/06/28 00:00 [accepted] PHST- 2026/10/26 17:31 [medline] PHST- 2026/08/04 00:35 [pubmed] PHST- 2026/08/03 23:52 [entrez] AID - 10.1007/s00266-026-06197-0 [pii] AID - 10.1007/s00266-026-06197-0 [doi] PST - ppublish SO - Aesthetic Plast Surg. 2026 Oct;50(19):7905-7919. doi: 10.1007/s00266-026-06197-0. Epub 2026 Aug 3. PMID- 42547504 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260824 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Aug 3 TI - Psychosocial and dietary influences on eating behaviors and body mass index among geographically diverse Indian university students. LID - 10.1038/s41598-026-48491-6 [doi] LID - 23865 AB - In the context of India's growing youth population, the interplay of dietary habits, social influences, and psychological factors critically shapes nutritional health outcomes. This cross-sectional study examined the socio-demographic, dietary, psychological, and social determinants of eating behaviour and their association with body mass index (BMI) among 3,150 undergraduate students from agricultural universities across six Indian regions. Using a validated self-administered questionnaire and anthropometric assessments, the study applied Principal Component Analysis (PCA) on 14 binary behavioural variables to identify latent dimensions influencing dietary patterns. The key behavioral components associated with BMI were: External Cues & Emotional Reactivity (PC2) (beta = +2.04, r = + 0.77), characterized by emotional eating and responsiveness to food advertisements; Dietary Practices & Cultural Disengagement (PC1) (beta = -1.54, r = - 0.58), reflecting structured dietary habits independent of cultural food norms; and Positive Affect & Peer Independence (PC6) (beta = -0.84, r = - 0.31), indicating emotionally positive, peer-independent eating. Dietary assessments revealed that although cereal consumption was adequate (100%), notable deficiencies were observed in the intake of green leafy vegetables, milk, and fruits, with consumption levels falling approximately 31-34%, 13-18%, and 10-20% below recommended dietary guidelines, respectively. The findings highlighted that beyond nutritional deficits, psychosocial factors including emotional reactivity and social pressures significantly influence students' weight status. Emotional vulnerability and environmental cues linked with higher BMI, whereas structured eating and emotional well-being are protective. This research underscores the need for gender and socially sensitive nutrition programs in Indian universities to prevent both obesity and undernutrition. CI - (c) 2026. The Author(s). FAU - Mahra, Girijesh Singh AU - Mahra GS AD - ICAR-Indian Agricultural Research Institute, New Delhi, India. girijeshmahra22@gmail.com. FAU - Joshi, Pratibha AU - Joshi P AD - ICAR-Indian Agricultural Research Institute, New Delhi, India. pratijosh12@gmail.com. FAU - Satyapriya AU - Satyapriya AD - ICAR-Indian Agricultural Research Institute, New Delhi, India. satya118ext@gmail.com. FAU - Bishnoi, Sitaram AU - Bishnoi S AD - ICAR-Indian Agricultural Research Institute, New Delhi, India. srext2011@gmail.com. FAU - Sahu, Subhashree AU - Sahu S AD - ICAR-Indian Agricultural Research Institute, New Delhi, India. FAU - Barua, Sukanya AU - Barua S AD - ICAR-Indian Agricultural Research Institute, New Delhi, India. FAU - Burman, Rajarshi Roy AU - Burman RR AD - Division of Agricultural Extension, Indian Council of Agricultural Research, New Delhi, India. LA - eng PT - Journal Article DEP - 20260803 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Male MH - *Students/psychology MH - *Feeding Behavior/psychology MH - India MH - *Body Mass Index MH - Universities MH - Cross-Sectional Studies MH - Young Adult MH - *Diet MH - Adolescent MH - Emotional Eating MH - Adult MH - Surveys and Questionnaires PMC - PMC13434682 OTO - NOTNLM OT - Consumption pattern OT - Demographic dividend OT - Dietary habits OT - Social and psychological factors COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: All methods used in this study were conducted in accordance with the relevant guidelines and regulations. The study received approval from the Research Ethics Committee of the Division of Agricultural Extension, ICAR-Indian Agricultural Research Institute, New Delhi, India (Approval No. Ag Extn/2025/579(A), Date: 01 January, 2025). Informed consent was obtained from each participant, and their confidentiality was ensured throughout the study. EDAT- 2026/08/04 00:35 MHDA- 2026/08/04 00:36 PMCR- 2026/08/03 CRDT- 2026/08/03 23:18 PHST- 2025/07/29 00:00 [received] PHST- 2026/04/08 00:00 [accepted] PHST- 2026/08/04 00:36 [medline] PHST- 2026/08/04 00:35 [pubmed] PHST- 2026/08/03 23:18 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - 10.1038/s41598-026-48491-6 [pii] AID - 48491 [pii] AID - 10.1038/s41598-026-48491-6 [doi] PST - epublish SO - Sci Rep. 2026 Aug 3;16(1):23865. doi: 10.1038/s41598-026-48491-6. PMID- 42547409 OWN - NLM STAT- Publisher LR - 20260803 IS - 1941-2444 (Electronic) IS - 0148-6071 (Linking) DP - 2026 Aug 3 TI - Nutritional and environmental determinants of maturation and disruption of the early life gut microbiome: A narrative review. LID - 10.1002/jpen.70127 [doi] AB - The first 1000 days of life represent a critical window for gut microbiome assembly, with lifelong implications for child growth, immune development, and disease risk. This review synthesizes evidence on maternal, perinatal, and especially nutritional factors that influence early-life intestinal colonization and highlights the consequences of microbial disruptions during this period. In utero exposures and birth-associated factors can profoundly shape microbial development, reducing diversity and beneficial taxa. Nutrition exerts a particularly dominant and modifiable influence: breastfeeding supports Bifidobacterium-rich communities, while formula use and early complementary feeding shape microbiota diversity and metabolic function. Dietary quality, fiber intake, and food diversity are key determinants of microbial maturation and resilience. Undernutrition and inadequate diets contribute to microbial dysbiosis, creating a self-reinforcing cycle of malabsorption, growth failure, and long-term metabolic consequences. Early microbial perturbations are associated with a range of acute and chronic diseases, including necrotizing enterocolitis, obesity, type 1 diabetes, inflammatory bowel disease, and atopic disorders. Strategies to restore microbial balance require further validation, particularly in nutritionally vulnerable populations. The absence of a universal definition for a "healthy" pediatric microbiome limits the development of targeted interventions. Emerging metrics, such as microbiota-for-age z-scores and functional microbiome profiling, may help define microbiota maturity and therapeutic efficacy. CI - (c) 2026 The Author(s). Journal of Parenteral and Enteral Nutrition published by Wiley Periodicals LLC on behalf of American Society for Parenteral and Enteral Nutrition. FAU - Burow, Carly AU - Burow C AUID- ORCID: 0000-0002-2033-672X AD - Faculty of Science, McMaster University, Hamilton, Ontario, Canada. AD - Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada. FAU - Shenderey, Romy AU - Shenderey R AD - Faculty of Health Science, McMaster University, Hamilton, Ontario, Canada. AD - Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. FAU - Chowdhury, Fariha AU - Chowdhury F AUID- ORCID: 0000-0002-9760-186X AD - Faculty of Science, McMaster University, Hamilton, Ontario, Canada. FAU - Shah, Nyah AU - Shah N AD - Faculty of Health Science, McMaster University, Hamilton, Ontario, Canada. AD - Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. FAU - Pai, Nikhil AU - Pai N AUID- ORCID: 0000-0002-7537-6059 AD - Department of Pediatrics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. AD - Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. AD - Division of Gastroenterology, Hepatology & Nutrition, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. AD - Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. LA - eng PT - Journal Article PT - Review DEP - 20260803 PL - United States TA - JPEN J Parenter Enteral Nutr JT - JPEN. Journal of parenteral and enteral nutrition JID - 7804134 SB - IM OTO - NOTNLM OT - life cycle OT - microbiome OT - nutrition OT - pediatrics OT - research and diseases EDAT- 2026/08/04 00:35 MHDA- 2026/08/04 00:35 CRDT- 2026/08/03 22:02 PHST- 2026/06/16 00:00 [revised] PHST- 2025/11/17 00:00 [received] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/08/04 00:35 [medline] PHST- 2026/08/04 00:35 [pubmed] PHST- 2026/08/03 22:02 [entrez] AID - 10.1002/jpen.70127 [doi] PST - aheadofprint SO - JPEN J Parenter Enteral Nutr. 2026 Aug 3. doi: 10.1002/jpen.70127. PMID- 42546580 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260904 IS - 1872-6232 (Electronic) IS - 0378-3782 (Linking) VI - 222 DP - 2026 Nov TI - Validation of the German version of the Brief Infant Sleep Questionnaire (BISQ) and associations with infant development. PG - 106629 LID - S0378-3782(26)00155-6 [pii] LID - 10.1016/j.earlhumdev.2026.106629 [doi] AB - BACKGROUND AND OBJECTIVES: Sleep problems such as prolonged night waking and difficulty falling asleep are common in infants. Sleep problems can affect development and put parents at risk of sleep deprivation, potentially leading to stress and burnout. It is therefore important to identify sleep problems early to facilitate targeted intervention and support. The Brief Infant Sleep Questionnaire (BISQ) developed by Sadeh (2004) is a widely used tool to identify and describe sleep behavior. However, a validated German translation is still missing. The main aim was to validate the German version of the BISQ by evaluating whether it captures age-related changes in sleep behavior whether it can distinguish between infants with and without sleep problems similarly to the original version. METHODS: We validated the German version of the BISQ by secondary analyses including N = 562 infants aged 6 to 24 months from seven independent samples and examined relations to infant development. Caregivers completed the German version of the BISQ. Additionally, parents in a subset of samples completed the Ages and Stages Questionnaires to assess developmental progress. To validate the BISQ against an objective measure, infants in three of the samples wore an actiwatch for a single night. RESULTS: Results showed age-related changes in sleep measures as assessed by the BISQ. Significant moderate correlations emerged between caregiver-reported night sleep duration and night wakings and one night of actigraphy. Additionally, BISQ sleep measures differed between infants whose parents reported a sleep problem and those who did not. The infant's sleep location (in own vs. shared bed) was a significant predictor of BISQ measures. Infants who slept alone in a separate room had more favorable sleep measures than infants who slept in the parent's room or the parent's bed. Daytime sleep duration and the time taken to fall asleep at night were positively associated with gross motor development, whereas nocturnal sleep duration was negatively associated. CONCLUSION: Our findings suggest that the German BISQ is a valid, quick-to-administer instrument for assessing infant sleep. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Konrad, Carolin AU - Konrad C AD - Developmental Psychology, Faculty of Psychology, Ruhr University Bochum, Universitatsstrasse 150, 44801, Bochum, Germany. Electronic address: carolin.konrad@rub.de. FAU - Schneider, Silvia AU - Schneider S AD - Clinical Child and Adolescent Psychology, Mental Health Research and Treatment Center, Faculty of Psychology, Ruhr University Bochum, Massenbergstrasse 9-13, 44787, Bochum, Germany; German Center for Mental Health (DZPG), partner site Bochum/Marburg, Germany. Electronic address: silvia.schneider@rub.de. FAU - Seehagen, Sabine AU - Seehagen S AD - Developmental Psychology, Faculty of Psychology, Ruhr University Bochum, Universitatsstrasse 150, 44801, Bochum, Germany; German Center for Mental Health (DZPG), partner site Bochum/Marburg, Germany. Electronic address: sabine.seehagen@rub.de. LA - eng PT - Journal Article PT - Validation Study DEP - 20260729 PL - Ireland TA - Early Hum Dev JT - Early human development JID - 7708381 SB - IM MH - Humans MH - Infant MH - Surveys and Questionnaires/standards MH - Male MH - *Sleep MH - Female MH - *Child Development MH - Child, Preschool MH - Sleep Duration MH - Germany MH - *Sleep Wake Disorders/diagnosis MH - Actigraphy OTO - NOTNLM OT - Actigraphy OT - Infancy OT - Infant development OT - Sleep OT - Sleep problem COIS- Declaration of competing interest The authors have no competing interests to declare. EDAT- 2026/08/04 00:35 MHDA- 2026/09/04 23:36 CRDT- 2026/08/03 18:07 PHST- 2026/04/30 00:00 [received] PHST- 2026/07/21 00:00 [revised] PHST- 2026/07/26 00:00 [accepted] PHST- 2026/09/04 23:36 [medline] PHST- 2026/08/04 00:35 [pubmed] PHST- 2026/08/03 18:07 [entrez] AID - S0378-3782(26)00155-6 [pii] AID - 10.1016/j.earlhumdev.2026.106629 [doi] PST - ppublish SO - Early Hum Dev. 2026 Nov;222:106629. doi: 10.1016/j.earlhumdev.2026.106629. Epub 2026 Jul 29. PMID- 42545817 OWN - NLM STAT- Publisher LR - 20260803 IS - 1950-6945 (Electronic) IS - 1294-9361 (Linking) DP - 2026 Aug 3 TI - Dietary patterns in children with epilepsy: The role of household environment and clinical comorbidities. LID - 10.1002/epd2.70362 [doi] AB - OBJECTIVE: To evaluate dietary patterns in children with epilepsy and compare them with age- and sex-matched healthy siblings living in the same household environment. Associations between clinical characteristics and dietary adequacy were also examined. METHODS: This cross-sectional study included 58 participants (37 with epilepsy and 21 sibling controls), aged 2-18 years, recruited from a tertiary epilepsy clinic. Dietary intake was assessed using validated, age-specific food frequency questionnaires and classified according to national recommendations. Regression models were used to identify predictors of dietary intake and adequacy. RESULTS: Both groups exhibited inadequate consumption of cereals, fruits, and vegetables, and excessive intake of sugary and ultra-processed foods. No significant differences in dietary intake or adequacy were found between children with epilepsy and their siblings. Within the epilepsy group, motor impairment, and constipation were associated with higher vegetable intake. Conversely, intellectual disability and developmental delay were linked to lower vegetable and fruit intake respectively. Autism spectrum disorder decreased the odds of inadequate vegetable intake, while intellectual disability and younger age increased it. SIGNIFICANCE: Children and adolescents with epilepsy exhibited similar dietary patterns to their healthy siblings, while within the epilepsy group, clinical characteristics, and comorbidities were associated with significant variations in dietary intake and adequacy. These findings suggest that nutritional counseling in pediatric epilepsy should be tailored to clinical comorbidities and family context rather than epilepsy diagnosis alone. CI - (c) 2026 The Author(s). Epileptic Disorders published by Wiley Periodicals LLC on behalf of International League Against Epilepsy. FAU - Oliveira, Ana Claudia Candido AU - Oliveira ACC AD - Child Neurology Service, Department of Neurology, University of Campinas (UNICAMP), Campinas, Brazil. FAU - Santana, Maria Eduarda Pereira AU - Santana MEP AD - Child Neurology Service, Department of Neurology, University of Campinas (UNICAMP), Campinas, Brazil. FAU - Zanin, Giuliane V M AU - Zanin GVM AD - Child Neurology Service, Department of Neurology, University of Campinas (UNICAMP), Campinas, Brazil. FAU - da Silva, Jaqueline Lamas AU - da Silva JL AUID- ORCID: 0009-0007-5482-141X AD - Department of Statistics, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Brazil. FAU - Zeller, Camila Borelli AU - Zeller CB AUID- ORCID: 0000-0002-1042-7425 AD - Department of Statistics, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Brazil. FAU - Coan, Ana Carolina AU - Coan AC AUID- ORCID: 0000-0002-2888-929X AD - Child Neurology Service, Department of Neurology, University of Campinas (UNICAMP), Campinas, Brazil. AD - Brazilian Institute of Neuroscience and Neurotechnology, BRAINN at UNICAMP, Campinas, SP, Brazil. AD - Neuroimaging Laboratory, UNICAMP, Campinas, SP, Brazil. LA - eng GR - 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ PT - Journal Article DEP - 20260803 PL - United States TA - Epileptic Disord JT - Epileptic disorders : international epilepsy journal with videotape JID - 100891853 SB - IM OTO - NOTNLM OT - children OT - diet OT - epilepsy OT - food frequency questionnaire OT - nutritional adequacy EDAT- 2026/08/03 18:37 MHDA- 2026/08/03 18:37 CRDT- 2026/08/03 12:38 PHST- 2026/07/09 00:00 [revised] PHST- 2026/02/13 00:00 [received] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/08/03 18:37 [medline] PHST- 2026/08/03 18:37 [pubmed] PHST- 2026/08/03 12:38 [entrez] AID - 10.1002/epd2.70362 [doi] PST - aheadofprint SO - Epileptic Disord. 2026 Aug 3. doi: 10.1002/epd2.70362. PMID- 42545147 OWN - NLM STAT- Publisher LR - 20260803 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) DP - 2026 Aug 3 TI - Maternal and newborn health in vegan and omnivore pregnancies: A prospective pilot study (PREGGIE). PG - 2601060261474598 LID - 10.1177/02601060261474598 [doi] AB - BackgroundFew studies have assessed health outcomes in pregnant vegans and their newborns.AimThis study aimed to examine this evidence gap.MethodsThis pilot study compared health parameters of pregnant vegans (n = 32) and omnivores (n = 13), as well as their newborns, in Germany (2019-2022). Maternal body mass index, weight and blood pressure were measured at gestational weeks 9-16 (t1) and 35-38 (t2). Additional assessments included maternal weight gain and excessive weight gain (from the beginning of pregnancy to t2), delivery method, gestational age, preterm birth, sex ratio, birth weight and length, small/large for gestational age, low birth weight, macrosomia, head circumference, and Apgar scores.SummaryNo significant differences were observed between the vegan and omnivore groups for any newborn outcomes, birth characteristics, or maternal health parameters. No preterm births occurred. Small for gestational age was observed in 2 vegan (6%) and 3 omnivore newborns (23%). Low birth weight (<2500 g) occurred in 1 vegan newborn (3%) and in no omnivore newborns. An Apgar score <10 at 10 min was recorded in 1 vegan (3%) and 1 (8%) omnivore newborn (both scoring 8).This study detected no clear adverse effects of a supplemented vegan diet (vitamin B12, iodine, vitamin D, omega-3 fatty acids) during pregnancy. Differences between vegans and omnivores cannot be excluded. The study was underpowered and baseline differences limit group comparability, validity, and generalizability. The study highlights key parameters and underscores the need to maximize group comparability in future research. FAU - Koeder, Christian AU - Koeder C AUID- ORCID: 0000-0002-3761-4220 AD - Institute for Prevention and Cancer Epidemiology (IPE), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. RINGGOLD: 14879 AD - Research Institute for Plant-Based Nutrition (IFPE), Biebertal, Germany. FAU - Feuerlein, Katharina AU - Feuerlein K AD - Fakultat fur Gesundheit, University Witten/Herdecke, Witten, Germany. RINGGOLD: 235785 FAU - Stanislas, Virginie AU - Stanislas V AD - Institute for Prevention and Cancer Epidemiology (IPE), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. RINGGOLD: 14879 FAU - Zerback, Tim AU - Zerback T AD - Research Institute for Plant-Based Nutrition (IFPE), Biebertal, Germany. FAU - Weder, Stine AU - Weder S AD - Research Institute for Plant-Based Nutrition (IFPE), Biebertal, Germany. FAU - Langler, Alfred AU - Langler A AD - Fakultat fur Gesundheit, Professur fur integrative Kinder- und Jugendmedizin, University Witten/Herdecke, Witten, Germany. RINGGOLD: 235785 AD - Gemeinschaftskrankenhaus Herdecke, Klinik fur Kinder- und Jugendmedizin, Herdecke, Germany. FAU - Alexy, Ute AU - Alexy U AD - Institute of Nutritional and Food Sciences-Nutritional Epidemiology, University of Bonn, Bonn, Germany. RINGGOLD: 9374 FAU - Keller, Markus AU - Keller M AD - Research Institute for Plant-Based Nutrition (IFPE), Biebertal, Germany. LA - eng PT - Journal Article DEP - 20260803 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 SB - IM OTO - NOTNLM OT - Vegan diet OT - infants OT - maternal nutrition OT - newborn OT - plant-based diet OT - pregnancy OT - premature birth OT - vegetarian diet EDAT- 2026/08/03 12:42 MHDA- 2026/08/03 12:42 CRDT- 2026/08/03 09:52 PHST- 2026/08/03 12:42 [medline] PHST- 2026/08/03 12:42 [pubmed] PHST- 2026/08/03 09:52 [entrez] AID - 10.1177/02601060261474598 [doi] PST - aheadofprint SO - Nutr Health. 2026 Aug 3:2601060261474598. doi: 10.1177/02601060261474598. PMID- 42542448 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261025 IS - 1476-5640 (Electronic) IS - 0954-3007 (Print) IS - 0954-3007 (Linking) VI - 80 IP - 10 DP - 2026 Oct TI - Food selection, cardiorespiratory fitness and the longitudinal association with adiposity among South African school children: the ExAMIN Youth SA study. PG - 1025-1032 LID - 10.1038/s41430-026-01799-y [doi] AB - BACKGROUND: The global pandemic of paediatric obesity, unhealthy diets and physical inactivity are important future health challenges. The purpose of this study was to determine 4-year changes in food selection, cardiorespiratory fitness (CRF), and the longitudinal association with the development of adiposity among South African primary school-age children. METHODS: School children aged 5-9 years old in 2017 (n = 950) were followed up for four years. Parents indicated selection from healthy and unhealthy food groups in a validated questionnaire. Weight and height of the children were measured, and WHO BMI z-score (BAZ) was calculated. CRF was determined by the 20 m shuttle run test (20-m SRT). Changes in food selection frequency, CRF and BAZ were assessed. The association between frequency of food group selection, age, household income and CRF with 4-year change in BAZ was determined using mixed linear models. RESULTS: BAZ (p < 0.001) and age-adjusted performance in the 20-m SRT of boys (p = 0.04) increased at follow-up. The frequency of sugar-sweetened beverages (p < 0.001) and milk intake (p < 0.02) decreased, while the intake from fast-foods increased (p = 0.001). Daily intakes of vegetables and milk were associated with decreases in BAZ. A trend of a positive association was found between frequency of SSB intake and BAZ. CRF showed a strong negative association with BAZ over time (p < 0.001). CONCLUSIONS: Higher daily vegetable and milk intakes, as well as higher levels of CRF were protective against increasing adiposity among school-age children. The promotion of healthy eating and measures to improve CRF among school children are important priorities. CI - (c) 2026. The Author(s). FAU - Kruger, Herculina Salome AU - Kruger HS AUID- ORCID: 0000-0002-5365-1777 AD - Centre of Excellence for Nutrition, North-West University, Potchefstroom, South Africa. salome.kruger@nwu.ac.za. AD - Medical Research Council Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa. salome.kruger@nwu.ac.za. FAU - Ricci, Cristian AU - Ricci C AUID- ORCID: 0000-0003-4113-8682 AD - African Unit for Transdisciplinary Health Research, North-West University, Potchefstroom, South Africa. FAU - Pienaar, Anita Elizabeth AU - Pienaar AE AD - Physical Activity, Sport and Recreation Research Focus Area, North-West University, Potchefstroom, South Africa. FAU - Monyeki, Makama Andries AU - Monyeki MA AD - Physical Activity, Sport and Recreation Research Focus Area, North-West University, Potchefstroom, South Africa. FAU - van Zyl, Tertia AU - van Zyl T AD - Centre of Excellence for Nutrition, North-West University, Potchefstroom, South Africa. AD - Medical Research Council Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa. FAU - Ricci, Hannah AU - Ricci H AD - African Unit for Transdisciplinary Health Research, North-West University, Potchefstroom, South Africa. FAU - Kruger, Ruan AU - Kruger R AUID- ORCID: 0000-0001-7680-2032 AD - Medical Research Council Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa. AD - Hypertension in Africa Research Team, North-West University, Potchefstroom, South Africa. LA - eng GR - 86895/South African Medical Research Council (SAMRC)/ PT - Journal Article DEP - 20260801 PL - England TA - Eur J Clin Nutr JT - European journal of clinical nutrition JID - 8804070 SB - IM MH - Humans MH - Male MH - Child MH - South Africa/epidemiology MH - *Cardiorespiratory Fitness/physiology MH - Female MH - Longitudinal Studies MH - *Adiposity/physiology MH - Child, Preschool MH - *Food Preferences MH - *Diet/statistics & numerical data MH - Body Mass Index MH - *Pediatric Obesity/epidemiology MH - Animals MH - Schools PMC - PMC13690588 COIS- Competing interests: HSK is a member of the Research Grants Panel of the South African Sugar Association and receives an honorarium for the review of grant applications. The South African Sugar Association played no role in the design of the study, collection and analysis of data and the decision to submit this manuscript for publication. The other authors declare no competing interests. Ethical approval: The study protocol was approved by the Centre of Excellence Scientific Review Committee of the North-West University. The researchers obtained approval from the Health Research Ethics Committee (NWU-00091-16-A1) of the North-West University to conduct the study. The parents and caregivers signed informed consent forms for the children while children, whose parents consented, signed assent forms for their participation in the study after they were provided with information about this study and their role and rights as participants. All methods were performed in accordance with the relevant guidelines and regulations. Anthropometry methods were performed according to the International Society for the Advancement of Kinanthropometry protocol. The food group questionnaire data collection was based on validated questionnaire methods. The 20 m shuttle run methods were performed according to published guidelines for the assessment and interpretation of data in relation to youth aerobic fitness and health. EDAT- 2026/08/02 00:50 MHDA- 2026/10/23 23:30 PMCR- 2026/08/01 CRDT- 2026/08/01 23:18 PHST- 2025/08/14 00:00 [received] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/06/26 00:00 [revised] PHST- 2026/10/23 23:30 [medline] PHST- 2026/08/02 00:50 [pubmed] PHST- 2026/08/01 23:18 [entrez] PHST- 2026/08/01 00:00 [pmc-release] AID - 10.1038/s41430-026-01799-y [pii] AID - 1799 [pii] AID - 10.1038/s41430-026-01799-y [doi] PST - ppublish SO - Eur J Clin Nutr. 2026 Oct;80(10):1025-1032. doi: 10.1038/s41430-026-01799-y. Epub 2026 Aug 1. PMID- 42540724 OWN - NLM STAT- MEDLINE DCOM- 20260801 LR - 20260813 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Criterion validity assessment of the 24-hour movement behaviors questionnaire (24HMBQ) for Chinese college students: validation study. PG - e21490 LID - 10.7717/peerj.21490 [doi] LID - e21490 AB - BACKGROUND: Accumulating studies have investigated the combined effects of 24-h movement behaviors on physical and mental health. The 24-hour Movement Behaviors Questionnaire (24HMBQ) was recently developed to measure the 24-hour movement behaviors in college students. However, its criterion validity remains to be elucidated. This study aimed to investigate the criterion validity of the 24HMBQ against accelerometer-derived data among Chinese college students. METHODS: Eighty-eight college students (age = 20.2 +/- 2.2 years) participated in this study. The Axivity AX3 accelerometers were used to objectively measure physical activity (PA), sedentary behavior (SB), and sleep levels over a consecutive seven-day period. At the last day, participants completed the 24HMBQ to self-report their PA, SB, and sleep levels. Paired-sample t-test, Spearman's rank correlation test, and Bland-Altman plot were used to examine the degree of agreement between 24HMBQ and accelerometer data. RESULTS: Spearman's correlation coefficients indicated strong agreement for sleep metrics (Rho = 0.77, p < 0.001 for weekdays; Rho = 0.68, p < 0.001 for weekends) and moderate agreement for SB (Rho = 0.55, p < 0.001 for weekdays; Rho = 0.33, p < 0.01 for weekends) between 24HMBQ and accelerometer measurements. However, lower correlations were observed for physical activities including light PA (Rho = 0.30, p < 0.01) and moderate-to-vigorous PA (MVPA; Rho = 0.15, p > 0.05). CONCLUSION: The 24HMBQ showed good criterion validity for sleep and moderate validity for sedentary behavior, but limited validity for physical activity (especially MVPA). CI - (c)2026 Tan et al. FAU - Tan, Teck Cheng AU - Tan TC AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Zheng, Jiaxin AU - Zheng J AD - School of Physical Education and Sport Science, Fujian Normal University, Fuzhou, China. FAU - Chen, Tianle AU - Chen T AD - Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China. FAU - Liu, Yiting AU - Liu Y AD - Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China. FAU - Luo, Yan AU - Luo Y AD - Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China. FAU - Yang, Yanxiang AU - Yang Y AD - Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China. FAU - Huang, Tao AU - Huang T AD - Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260728 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - Female MH - *Students/statistics & numerical data MH - Surveys and Questionnaires/standards MH - Young Adult MH - *Exercise MH - Male MH - Accelerometry MH - Universities MH - Reproducibility of Results MH - *Sedentary Behavior MH - Sleep MH - China MH - Sleep Duration MH - Adolescent PMC - PMC13426337 OTO - NOTNLM OT - 24-hour movement behavior OT - Accelerometer OT - College students OT - Criterion validity OT - Questionnaire COIS- The authors declare there are no competing interests. EDAT- 2026/08/02 00:30 MHDA- 2026/08/02 00:31 PMCR- 2026/07/28 CRDT- 2026/08/01 06:42 PHST- 2025/12/15 00:00 [received] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/08/02 00:31 [medline] PHST- 2026/08/02 00:30 [pubmed] PHST- 2026/08/01 06:42 [entrez] PHST- 2026/07/28 00:00 [pmc-release] AID - 21490 [pii] AID - 10.7717/peerj.21490 [doi] PST - epublish SO - PeerJ. 2026 Jul 28;14:e21490. doi: 10.7717/peerj.21490. eCollection 2026. PMID- 42539487 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260801 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Physical literacy and mental well-being in adults: a cross-sectional examination of their association and links with physical activity engagement. PG - 1908692 LID - 10.3389/fpsyg.2026.1908692 [doi] LID - 1908692 AB - BACKGROUND: Physical literacy, the integrated motivation, confidence, physical competence, knowledge, and understanding that underpins lifelong physical activity, has been advanced as a holistic determinant of health. Yet, evidence linking it to positively framed mental well-being in adults remains scarce and is dominated by samples of children and adolescents. AIM: This study examined the association between physical literacy and mental well-being in Turkish adults and tested whether both constructs differed by sex, educational attainment, athletic background, regular exercise participation, and habitual physical activity level. METHODS: In a cross-sectional design, 375 adults (64.5% male; mean age = 32.23 years, SD = 11.03, range 18-71), a convenience sample skewed toward physically active and tertiary-educated men, completed validated Turkish measures of physical literacy and mental well-being. Active-living exposures were assessed using a single self-report item. Internal consistency was high (physical literacy alpha = 0.89, omega = 0.90; mental well-being alpha = 0.92, omega = 0.92). Pearson correlations, t-tests, one-way ANOVAs, and hierarchical regression were computed with effect sizes and 95% confidence intervals; discriminant validity was tested directly, and an exploratory mediation was examined. RESULTS: Physical literacy was moderately and positively associated with mental well-being (r = 0.45, p < 0.001), and the two constructs showed evidence of empirical distinctness (HTMT = 0.52, 95% CI [0.42, 0.63]). Adults with an athletic background and regular exercisers reported higher physical literacy (d = 0.83 and 1.09) and mental well-being (d = 0.36 and 0.63), and both outcomes increased in an ordered gradient across habitual activity-frequency categories (physical literacy eta(2) = 0.21; mental well-being eta(2) = 0.07). Physical literacy explained 11% of incremental variance in well-being beyond demographic and behavioral covariates (beta = 0.41). Men scored marginally higher than women on both measures, educational attainment was weakly related to mental well-being but not physical literacy, and physical literacy declined modestly with age (r = -0.18). CONCLUSION: Higher physical literacy co-occurs with better mental well-being in adults and remains associated with mental well-being after adjustment for covariates, positioning it as a candidate target for adult mental health promotion. The cross-sectional design and active, educated convenience sample preclude causal and population-level inference, and independent confirmatory validation of the adapted instrument is needed before these findings are treated as more than provisional. CI - Copyright (c) 2026 Orhan, Alkasasbeh, Karacam, Branquinho and Amawi. FAU - Orhan, Bekir Erhan AU - Orhan BE AD - Faculty of Sports Sciences, Istanbul Aydin University, Istanbul, Turkiye. FAU - Alkasasbeh, Walaa Jumah AU - Alkasasbeh WJ AD - Department of Physical Education, Faculty of Sport Science, The University of Jordan, Amman, Jordan. FAU - Karacam, Aydin AU - Karacam A AD - Faculty of Sport Sciences, Bandirma Onyedi Eylul University, Balikesir, Turkiye. FAU - Branquinho, Luis AU - Branquinho L AD - Biosciences School of Elvas, Polytechnic University of Portalegre, Elvas, Portugal. AD - Life Quality Research Center (LQRC-CIEQV), Santarem, Portugal. AD - Research Center in Sports Sciences, Health Sciences and Human Development, Covilha, Portugal. AD - Centro De Investigacao Do Instituto Superior De Ciencia Educativas (CI-ISCE), Penafiel, Portugal. FAU - Amawi, Adam Tawfiq AU - Amawi AT AD - Department of Movement Sciences and Sports Training, School of Sports Science, The University of Jordan, Amman, Jordan. LA - eng PT - Journal Article DEP - 20260717 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13423689 OTO - NOTNLM OT - health promotion OT - mental well-being OT - physical activity OT - physical literacy OT - self-determination theory OT - sustainable health COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer AR declared a past collaboration with the authors BO and LB to the handling editor. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/08/02 00:30 MHDA- 2026/08/02 00:31 PMCR- 2026/07/17 CRDT- 2026/08/01 06:07 PHST- 2026/06/14 00:00 [received] PHST- 2026/06/22 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/08/02 00:31 [medline] PHST- 2026/08/02 00:30 [pubmed] PHST- 2026/08/01 06:07 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1908692 [doi] PST - epublish SO - Front Psychol. 2026 Jul 17;17:1908692. doi: 10.3389/fpsyg.2026.1908692. eCollection 2026. PMID- 42539320 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260801 LR - 20260813 IS - 2688-4844 (Electronic) IS - 2688-4844 (Linking) VI - 7 DP - 2026 Jan-Dec TI - Obesity among Obstetrical Patients Seeking Care in a Safety Net Hospital: The Impact of Adverse Childhood Events. PG - 26884844261445331 LID - 10.1177/26884844261445331 [doi] LID - 26884844261445331 AB - OBJECTIVE: To determine the prevalence of obesity among a cohort of pregnant patients with high compared with low adverse childhood events scores. STUDY DESIGN DESCRIPTIVE STUDY METHODS: The study was part of a large study of adverse childhood events among pregnant women seeking care in a safety net hospital from June 2022 to June 2023. The patients were seen in a variety of settings (a routine prenatal clinic, a high-risk clinic, an antepartum testing unit, an obstetrical ultrasound unit, and a labor and delivery suite). They were randomly approached and asked to complete a previously validated questionnaire for their Adverse Childhood Experience score (ACE score). Their body mass index (BMI) on their first visit was recorded. BMI was categorized as overweight (BMI > 25), class I obesity (BMI > 30), class II obesity (BMI > 35), and class III obesity (BMI > 40). This study was approved by the Valleywise Institutional Review Board. RESULTS: Three hundred and forty-nine patients were approached and 320 agreed to complete the questionnaire. Eighty percent of patients had an initial prenatal visit BMI >25 and 62% had an initial BMI that was categorized as obese. Patients with a high ACEs score were more likely to have a BMI in the obese category compared with those in the low-risk group with an odds ratio of 1.34 (95% CI [0.7907-2.2798], p = 0.275). CONCLUSION: Maternal obesity is a well-known risk factor for numerous adverse obstetrical and neonatal outcomes. While the CDC reported a national prepregnancy obesity rate of 29.0% in 2019, our patients were 2.14 times more likely to be obese. Obesity was more prevalent in women with high ACEs scores. Safety net hospitals should be cognizant of marked increase in obesity in their obstetrical patients, especially those with high ACEs scores, and develop interventions that incorporate trauma-informed care. CI - (c) The Author(s) 2026. Published by Mary Ann Liebert (NY), LLC. FAU - Goforth, Michelle AU - Goforth M AD - University of Arizona College of Medicine, Phoenix, Arizona, USA. FAU - Brady, Sarah R AU - Brady SR AD - University of Arizona College of Medicine, Phoenix, Arizona, USA. FAU - Chambliss, Linda R AU - Chambliss LR AUID- ORCID: 0000-0003-1518-9240 AD - University of Arizona College of Medicine, Phoenix, Arizona, USA. AD - Department of Obstetrics and Gynecology, Creighton University School of Medicine, Phoenix Regional Campus, Nebraska, USA. AD - Department of Obstetrics and Gynecology, Valleywise Health Center, Phoenix, Arizona, USA. LA - eng PT - Journal Article DEP - 20260531 PL - United States TA - Womens Health Rep (New Rochelle) JT - Women's health reports (New Rochelle, N.Y.) JID - 101768931 PMC - PMC13421971 OTO - NOTNLM OT - ACES score OT - adverse childhood events OT - childhood trauma OT - obesity OT - pregnancy COIS- No competing financial interests exist. EDAT- 2026/08/01 06:35 MHDA- 2026/08/01 06:36 PMCR- 2026/05/31 CRDT- 2026/08/01 06:01 PHST- 2025/12/04 00:00 [accepted] PHST- 2026/08/01 06:36 [medline] PHST- 2026/08/01 06:35 [pubmed] PHST- 2026/08/01 06:01 [entrez] PHST- 2026/05/31 00:00 [pmc-release] AID - 10.1177_26884844261445331 [pii] AID - 10.1177/26884844261445331 [doi] PST - epublish SO - Womens Health Rep (New Rochelle). 2026 May 31;7:26884844261445331. doi: 10.1177/26884844261445331. eCollection 2026 Jan-Dec. PMID- 42538742 OWN - NLM STAT- MEDLINE DCOM- 20260801 LR - 20260813 IS - 2090-2735 (Electronic) IS - 2090-2727 (Print) IS - 2090-2727 (Linking) VI - 2026 IP - 1 DP - 2026 TI - Associations Between Potential Listeria monocytogenes Exposure During Pregnancy and Infant Outcomes at Birth and Infant Delivery Resource Use: A Cross-Sectional Analysis in Australian Women. PG - e7824916 LID - 10.1155/jp/7824916 [doi] LID - 7824916 AB - Pregnant women are at higher risk of contracting listeriosis, which can lead to serious perinatal complications. This study evaluated associations between Listeria monocytogenes exposure, infant perinatal outcomes, and hospital resource use in a cohort of 1604 Australian mother-infant dyads. Maternal L. monocytogenes exposure was estimated from self-reported intake of foods from a validated food frequency questionnaire that potentially harbor L. monocytogenes. Infant outcomes obtained from hospital medical records included birth mode, preterm birth, birthweight, and admission to special care nursery (SCN)/neonatal intensive care unit (NICU). Infant hospital resource use was measured by infant length of stay (LOS), LOS in SCN/NICU, and days excluding SCN/NICU. Multinomial, negative binomial, and hurdle models, were performed to examine Listeria Food Exposure Score (LFES) associations with infant outcomes, total LOS, and LOS excluding and within SCN/NICU. All models were adjusted for covariates including smoking, parity, maternal age, BMI, and SEIFA IRSAD decile. Mean (SD) maternal age was 32.0 (5.0) years, and median (IQR) gestation was 39.0 (38.1, 40.0) weeks. Although adjusted results showed a statistically significant association between LFES and reduced infant LOS excluding SCN/NICU (beta = 0.99; 95% CI: 0.979, 0.998, p < 0.03), the effect size was minimal, with minor clinical significance. There were no significant associations with infant birth mode, preterm birth, low birthweight, size for gestational age, macrosomia, admission to NICU/SCN, total LOS in hospital, and SCN/NICU (all p > 0.05). Future research should explore these associations among ethnically diverse women at earlier stage of pregnancy and include the assessment of food safety practices in the analyses. CI - Copyright (c) 2026 Kee June Ooi et al. Journal of Pregnancy published by John Wiley & Sons Ltd. FAU - Ooi, Kee June AU - Ooi KJ AUID- ORCID: 0000-0002-1564-9799 AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia, ncl.ac.uk. AD - Nutrition and Metabolic Health Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia, hmri.com.au. FAU - Fenton, Sasha AU - Fenton S AUID- ORCID: 0000-0002-4611-5810 AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia, ncl.ac.uk. AD - Nutrition and Metabolic Health Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia, hmri.com.au. FAU - Taylor, Rachael AU - Taylor R AUID- ORCID: 0000-0002-1895-4123 AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia, ncl.ac.uk. AD - Nutrition and Metabolic Health Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia, hmri.com.au. FAU - Hinwood, Madeleine AU - Hinwood M AUID- ORCID: 0000-0002-2225-973X AD - Data Science, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia, hmri.com.au. AD - School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia, ncl.ac.uk. FAU - Pannu, Poonam Kaur AU - Pannu PK AUID- ORCID: 0009-0006-0724-4683 AD - The Kids Research Institute Australia, Nedlands, Western Australia, Australia. AD - Curtin University, Bentley, Western Australia, Australia, curtin.edu.au. FAU - Hutchesson, Melinda AU - Hutchesson M AUID- ORCID: 0000-0002-1851-0661 AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia, ncl.ac.uk. AD - Nutrition and Metabolic Health Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia, hmri.com.au. FAU - Collins, Clare E AU - Collins CE AUID- ORCID: 0000-0003-3298-756X AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia, ncl.ac.uk. AD - Nutrition and Metabolic Health Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia, hmri.com.au. LA - eng GR - Commonwealth Government of Australia/ GR - Paul Ramsay Foundation/ GR - Joondalup Health Campus/ GR - Telethon Perth Children's Hospital Research Fund/ GR - Hunter Medical Research Institute/ GR - APP2009340/National Health and Medical Research Council/ PT - Journal Article PL - United States TA - J Pregnancy JT - Journal of pregnancy JID - 101553823 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Infant, Newborn MH - Adult MH - Cross-Sectional Studies MH - *Listeria monocytogenes MH - Australia/epidemiology MH - *Listeriosis/epidemiology MH - *Pregnancy Complications, Infectious/epidemiology/microbiology MH - Pregnancy Outcome/epidemiology MH - Premature Birth/epidemiology MH - Length of Stay/statistics & numerical data MH - Intensive Care Units, Neonatal/statistics & numerical data MH - Birth Weight PMC - PMC13428182 OTO - NOTNLM OT - Listeria monocytogenes OT - ORIGINS OT - birth outcomes OT - hospital resource use OT - infant outcomes OT - listeriosis COIS- The authors declare no conflicts of interest. EDAT- 2026/08/01 06:35 MHDA- 2026/08/01 06:36 PMCR- 2026/07/31 CRDT- 2026/08/01 02:02 PHST- 2026/02/18 00:00 [revised] PHST- 2025/04/08 00:00 [received] PHST- 2026/07/16 00:00 [accepted] PHST- 2026/08/01 06:36 [medline] PHST- 2026/08/01 06:35 [pubmed] PHST- 2026/08/01 02:02 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - JP7824916 [pii] AID - 10.1155/jp/7824916 [doi] PST - ppublish SO - J Pregnancy. 2026;2026(1):e7824916. doi: 10.1155/jp/7824916. PMID- 42537500 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260826 IS - 1879-0739 (Electronic) IS - 0271-5317 (Linking) VI - 153 DP - 2026 Sep TI - Moderate MIND diet adherence and positive correlation between weekly egg intake and skin carotenoid scores in college students. PG - 78-85 LID - S0271-5317(26)00086-2 [pii] LID - 10.1016/j.nutres.2026.07.003 [doi] AB - Adherence to the Mediterranean-DASH diet intervention for neurodegenerative delay (MIND) diet, which emphasizes fruit and vegetables and thereby carotenoid intake, is associated with better cognitive health in older adults. However, as neurodegeneration is thought to progress over decades, adopting such a dietary pattern in young adulthood may help prevent its initiation and progression. The aim of this study was to determine whether scores on the MIND diet screener predict skin carotenoid scores in college students, as a measure of construct validity. Participants completed a modified 14-item MIND diet screener and an item on weekly egg intake. Skin carotenoids were assessed using pressure-mediated reflective spectroscopy by Veggie Meter, and the data were analyzed using Pearson correlations. Participants (n = 293; 62.5% female; 20.0 +/- 2.0 years) scored 8.3 +/- 2.1 on the screener, indicating suboptimal adherence to the MIND dietary pattern, and skin carotenoid scores averaged 305 +/- 90. MIND diet screener score predicted skin carotenoid score (r = 0.327; CI 0.220-0.425; P < .001), strengthened by adding the egg intake item (r = 0.353; CI 0.249-0.450; P < .001), and was highest in those consuming >/=7 eggs/wk (r = 0.50). Two dietary patterns emerged from clustering analysis, differentiated by intakes of leafy greens, other vegetables, berries, beans, and nuts. In conclusion, the MIND diet screener score predicts skin carotenoid content in young adults, supporting the tool's validity; however, frequent egg intake strongly moderated the relationship. Egg intake should be considered when interpreting skin carotenoid scores and included in future iterations of the MIND diet screener. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Hill, Chloe AU - Hill C AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. FAU - Foster, Victoria R AU - Foster VR AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. FAU - Patel, Arya B AU - Patel AB AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. FAU - Ribay, Gabriel D AU - Ribay GD AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. FAU - Sadlo, Margaret K AU - Sadlo MK AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. FAU - Senthilkumar, Neha AU - Senthilkumar N AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. FAU - Moreno, Melissa L AU - Moreno ML AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. FAU - Colee, James AU - Colee J AD - Institute of Food and Agricultural Sciences (IFAS) Statistics Department, University of Florida, Gainesville, FL, USA. FAU - Dahl, Wendy J AU - Dahl WJ AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. Electronic address: wdahl@ufl.edu. LA - eng PT - Journal Article DEP - 20260708 PL - United States TA - Nutr Res JT - Nutrition research (New York, N.Y.) JID - 8303331 RN - 36-88-4 (Carotenoids) SB - IM MH - Humans MH - Female MH - *Carotenoids/analysis MH - Male MH - *Skin/chemistry MH - Students MH - *Eggs MH - Young Adult MH - *Diet, Mediterranean MH - Vegetables MH - Fruit MH - Universities MH - Adolescent MH - *Feeding Behavior MH - Adult MH - Diet MH - *Patient Compliance OTO - NOTNLM OT - Carotenoids OT - Diet OT - Diet surveys OT - Egg yolk OT - Mediterranean-DASH diet intervention for neurodegenerative delay OT - Plant-based OT - Reflection spectroscopy COIS- Author declarations All authors declare that the research was conducted without commercial or financial relationships and that there is no conflict of interest. EDAT- 2026/08/01 00:36 MHDA- 2026/08/26 23:35 CRDT- 2026/07/31 18:06 PHST- 2026/02/16 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/08/26 23:35 [medline] PHST- 2026/08/01 00:36 [pubmed] PHST- 2026/07/31 18:06 [entrez] AID - S0271-5317(26)00086-2 [pii] AID - 10.1016/j.nutres.2026.07.003 [doi] PST - ppublish SO - Nutr Res. 2026 Sep;153:78-85. doi: 10.1016/j.nutres.2026.07.003. Epub 2026 Jul 8. PMID- 42533515 OWN - NLM STAT- MEDLINE DCOM- 20260731 LR - 20260731 IS - 1899-5276 (Print) IS - 1899-5276 (Linking) VI - 35 IP - 7 DP - 2026 Jul TI - Family and dietary risk factors associated with childhood sleep disorders: Evidence from a cross-sectional study in China. PG - 1235-1245 LID - 10.17219/acem/212573 [doi] AB - BACKGROUND: Childhood sleep disorders are common and are associated with familyand diet-related factors, such as parental snoring and unhealthy eating habits. However, culturally relevant studies remain limited, and existing research often overlooks weak correlations in large populations. OBJECTIVES: This study aimed to identify familyand diet-related risk factors for childhood sleep disorders in a Chinese population and to provide insights for prevention. MATERIAL AND METHODS: A cross-sectional study was conducted in Jinan, China, between January 2022 and December 2023, enrolling 845 children aged 1-7 years through convenience sampling. Sleep disorders were defined based on parent-reported symptoms (mouth breathing, habitual snoring, apnea, or gasping) using a validated questionnaire. Demographic, family, and dietary factors were collected. Associations were analyzed using multivariable logistic regression with stepwise selection based on the Akaike information criterion (AIC), adjusted for age, with subgroup analyses according to age (1-3, 4-5, and 6-7 years). Statistical significance was set at p < 0.05. RESULTS: Among the 845 children (mean age: 5.2 years), 192 (22.7%) had sleep disorders. Multivariable analysis showed that parental snoring (father: odds ratio (OR) = 2.20, 95% confidence interval (95% CI): 1.44-3.41; mother: OR = 1.76, 95% CI: 1.15-2.66), maternal education at the associate degree level (OR = 2.58, 95% CI: 1.27-5.66) or bachelor's degree level (OR = 2.44, 95% CI: 1.21-5.29), and children's preferences for fried foods (OR = 6.49, 95% CI: 2.51-17.40), meat (OR = 2.19, 95% CI: 1.43-3.35), and sweets (OR = 2.15, 95% CI: 1.31-3.51) were significant risk factors. Moderate sweet consumption (1-2 times/week: OR = 0.53, 95% CI: 0.29-0.95; 3-5 times/week: OR = 0.51, 95% CI: 0.27-0.94) was associated with a protective effect compared with daily consumption. CONCLUSIONS: Childhood sleep disorders were significantly associated with parental snoring, higher maternal educational attainment, and children's preferences for fried foods, meat, and sweets, whereas moderate sweet consumption appeared to have a protective effect. FAU - Zhang, Lifeng AU - Zhang L AD - The First College for Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China. AD - Department of Otolaryngology, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, China. FAU - Chen, Xiangjing AU - Chen X AD - Department of Otolaryngology, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, China. FAU - Zhang, Xin AU - Zhang X AD - Department of Otolaryngology, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, China. FAU - Yan, Ya AU - Yan Y AD - The First College for Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China. FAU - Wang, Renzhong AU - Wang R AD - Department of Otolaryngology, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, China. LA - eng PT - Journal Article PL - Poland TA - Adv Clin Exp Med JT - Advances in clinical and experimental medicine : official organ Wroclaw Medical University JID - 101138582 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Risk Factors MH - Female MH - *Sleep Wake Disorders/epidemiology/etiology MH - China/epidemiology MH - Child, Preschool MH - Male MH - Child MH - *Diet/adverse effects MH - Infant MH - Feeding Behavior MH - Snoring MH - Surveys and Questionnaires OTO - NOTNLM OT - childhood sleep disorders OT - dietary habits OT - maternal education OT - parental snoring OT - risk factors EDAT- 2026/07/31 06:37 MHDA- 2026/07/31 12:39 CRDT- 2026/07/31 02:02 PHST- 2025/06/18 00:00 [received] PHST- 2025/10/14 00:00 [accepted] PHST- 2026/07/31 12:39 [medline] PHST- 2026/07/31 06:37 [pubmed] PHST- 2026/07/31 02:02 [entrez] AID - 10.17219/acem/212573 [doi] PST - ppublish SO - Adv Clin Exp Med. 2026 Jul;35(7):1235-1245. doi: 10.17219/acem/212573. PMID- 42532561 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260918 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 7 DP - 2026 Jul 30 TI - Vietnam Cerebral Palsy Register: protocol for co-design of a national register with people with lived experience of cerebral palsy. PG - e116376 LID - 10.1136/bmjopen-2026-116376 [doi] LID - e116376 AB - INTRODUCTION: Cerebral palsy (CP) is the most common physical disability in childhood. Although an estimated 60 000 children live with CP in Vietnam, there is no national register to systematically collect data on the prevalence, risk factors or clinical profile of CP or service access. This paper outlines the protocol for establishing the Vietnam Cerebral Palsy Register (VCPR), a national register which will be co-designed by researchers and clinicians in collaboration with the Cerebral Palsy Family Association of Vietnam (CPFAV). The VCPR aims to inform service planning, policy and research through comprehensive, community-informed data collection. METHODS AND ANALYSIS: The VCPR will be developed by a consumer-clinician-researcher partnership. Initially, the VCPR will harmonise and pool data from two sources: (1) a hospital-based cohort of 765 children with CP identified at the National Children's Hospital in Hanoi (NCH) in 2017, and (2) members of the CPFAV, comprising over 4300 children with CP aged <18 years from 63 CPFAV hubs across Vietnam. Subsequently, standardised data for inclusion in the VCPR will prospectively be collected on children newly diagnosed with CP at NCH and other healthcare settings and on children newly referred to CPFAV.Data will be collected using an adapted version of the Australian CP register questionnaire through a combination of structured caregiver interviews, clinical assessments using validated tools and medical record review. Key demographic variables and information on CP type, motor severity-using the Gross Motor Function Classification System or Manual Ability Classification System, associated impairments (eg, vision, hearing, intellectual disabilities), condition at birth, congenital or other infections, vaccination, educational and nutritional status of the child, access to rehabilitation and family-related factors such as monthly household income, parental education and occupation and maternal health during pregnancy will be collected. The VCPR will contribute data to the Global Low- and Middle-Income Country Cerebral Palsy Register. ETHICS AND DISSEMINATION: Ethics approval has been obtained from Vietnamese and Australian institutions, whose role is to provide ethical oversight and research governance for the PhD project supporting the VCPR. Written informed consent will be obtained from primary caregivers for data collection, secure storage, access to relevant health records, verification with health professionals and future research contact, with no identifiable data disclosed.Involvement of people with lived experience of CP is central to the VCPR and leaders and members of the CPFAV will contribute to co-design, governance, participant engagement and dissemination. Findings will be shared regularly with families, clinicians, policymakers and researchers through CPFAV communications, peer-reviewed publications, national and international conferences and the VCPR website to inform equitable service planning, policy and future research. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Khuc, Thi Hong Hanh AU - Khuc THH AUID- ORCID: 0000-0002-9421-5517 AD - School of Health, Medical and Applied Sciences, Central Queensland University, Rockhampton, Queensland, Australia honghanhkhuc@gmail.com. AD - Faculty of Medical Technology, Phenikaa School of Medicine and Pharmacy, Phenikaa University, Hanoi, Viet Nam. FAU - Cao, Minh Chau AU - Cao MC AD - Faculty of Medical Technology, Phenikaa School of Medicine and Pharmacy, Phenikaa University, Hanoi, Viet Nam. FAU - Karim, Tasneem AU - Karim T AD - Cerebral Palsy Alliance Research Institute, Specialty of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. AD - Specialty of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. FAU - Dinh, Thi Lan Anh AU - Dinh TLA AD - Cerebral Palsy Family Association Vietnam, Hanoi, Viet Nam. FAU - Nguyen, Thi Huong Giang AU - Nguyen THG AD - Department of Rehabilitation, National Children's Hospital, Hanoi, Viet Nam. FAU - Nguyen, Thi Van Anh AU - Nguyen TVA AUID- ORCID: 0000-0002-3673-7288 AD - Department of Rehabilitation, National Children's Hospital, Hanoi, Viet Nam. FAU - Pham, Minh Chau AU - Pham MC AD - Faculty of Medical Technology, Phenikaa School of Medicine and Pharmacy, Phenikaa University, Hanoi, Viet Nam. FAU - Nguyen, Van Bang AU - Nguyen VB AD - Medical Faculty, Hoa Binh University, Hanoi, Viet Nam. FAU - Rawal, Lal AU - Rawal L AUID- ORCID: 0000-0003-1106-0108 AD - School of Health Medical and Applied Sciences, Central Queensland University, Sydney, New South Wales, Australia. AD - S.P.O.R.T. Research Cluster, Central Queensland University, Rockhampton, Queensland, Australia. FAU - Mcintyre, Sarah AU - Mcintyre S AD - Specialty of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. FAU - Khandaker, Gulam AU - Khandaker G AUID- ORCID: 0000-0002-0661-4113 AD - National Centre for Immunisation Research and Surveillance, Westmead, New South Wales, Australia. AD - Central Queensland Public Health Unit, Central Queensland Hospital and Health Service, Rockhampton, Queensland, Australia. FAU - Elliott, Elizabeth Jane AU - Elliott EJ AUID- ORCID: 0000-0002-6501-5487 AD - Specialty of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. AD - Kid's Research, The Sydney Children's Hospitals Network, Sydney, New South Wales, Australia. CN - Cerebral Palsy Family Association Vietnam LA - eng PT - Journal Article DEP - 20260730 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Cerebral Palsy/epidemiology MH - *Registries MH - Vietnam/epidemiology MH - Child MH - Adolescent MH - Child, Preschool MH - Female MH - Research Design MH - Male MH - Infant PMC - PMC13423169 OTO - NOTNLM OT - Community child health OT - Developmental neurology & neurodisability OT - Protocols & guidelines OT - REGISTRIES COIS- Competing interests: None declared. EDAT- 2026/07/31 00:38 MHDA- 2026/07/31 00:39 PMCR- 2026/07/30 CRDT- 2026/07/30 20:43 PHST- 2026/07/31 00:39 [medline] PHST- 2026/07/31 00:38 [pubmed] PHST- 2026/07/30 20:43 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - bmjopen-2026-116376 [pii] AID - 10.1136/bmjopen-2026-116376 [doi] PST - epublish SO - BMJ Open. 2026 Jul 30;16(7):e116376. doi: 10.1136/bmjopen-2026-116376. PMID- 42531267 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260730 LR - 20260825 IS - 2767-3375 (Electronic) IS - 2767-3375 (Linking) VI - 6 IP - 7 DP - 2026 TI - Prevalence, patterns and associated behavioural risk factors of multimorbidity in rural India: Cross-sectional analysis from the Andhra Pradesh Children and Parents Study (APCAPS). PG - e0006694 LID - 10.1371/journal.pgph.0006694 [doi] LID - e0006694 AB - The prevalence of multimorbidity is projected to increase substantially in India. Previous studies have focused on urban populations and older adults, who do not represent the majority of those at risk. We aimed to estimate the prevalence and investigate patterns of multimorbidity in a rural population in India and examine their associations with four common behavioural risk factors (BRFs): daily drinking, tobacco consumption, physical inactivity, and poor sleep. This cross-sectional analysis used data of all adult participants (aged >/=18 years, mean age of 35.5 years) from the third follow-up of Andhra Pradesh Children and Parents Study (APCAPS), 2010-12. We used binary logistic regression to examine the associations between BRFs, ascertained through validated questionnaires, and the prevalence of multimorbidity, defined as having two or more of 13 common chronic conditions. We used latent class analysis (LCA) to investigate common patterns of multimorbidity, followed by multinomial logistic regression to examine their associations with BRFs (categorised as binary), adjusted for age, sex, and household socioeconomic status. Of 5332 adult participants (mean age 35.5 years, standard deviation 13.8 years) included in the analysis, 14.2% had multimorbidity, the prevalence of which increased steeply with age. Current tobacco consumption (adjusted odds ratio (aOR) = 1.23 [95% confidence interval (CI): 1.01-1.50]), physical inactivity (aOR: 1.66 [95% CI: 1.38-1.99]), and poor sleep (aOR: 1.86 [95% CI: 1.35-2.57]) were associated with higher odds of having multimorbidity. We found one multimorbidity pattern of "anaemia and hypertension" (n = 220, 4.1%). Physical inactivity (aOR: 2.07 [95% CI: 1.52-2.82]) was associated with higher odds of having this multimorbidity pattern, with no associations found for the other BRFs. The BRFs identified, notably physical activity, could present important opportunities for intervention to reduce the burden of multimorbidity in India. Longitudinal studies are needed to confirm these relationships. CI - Copyright: (c) 2026 Song et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Song, Wenbo AU - Song W AUID- ORCID: 0000-0002-1588-8597 AD - Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. AD - School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan. AD - Department of Methodology, London School of Economics & Political Science, London, United Kingdom. FAU - Lieber, Judith AU - Lieber J AD - Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. FAU - Yamanashi, Hirotomo AU - Yamanashi H AD - School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan. AD - Department of General Medicine, Nagasaki University, Nagasaki, Japan. FAU - Matsuzaki, Mika AU - Matsuzaki M AD - Department of International Health, Johns Hopkins University, Baltimore, Maryland, United States of America. FAU - Lewin, Alex AU - Lewin A AUID- ORCID: 0000-0003-0081-7582 AD - Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. FAU - Gittelsohn, Joel AU - Gittelsohn J AD - Department of International Health, Johns Hopkins University, Baltimore, Maryland, United States of America. FAU - Hazell, Matthew AU - Hazell M AD - Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. FAU - Banjara, Santosh Kumar AU - Banjara SK AUID- ORCID: 0000-0002-0893-9552 AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, India. FAU - Mahajan, Hemant AU - Mahajan H AUID- ORCID: 0000-0001-7874-9191 AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, India. FAU - Bhogadi, Santhi AU - Bhogadi S AUID- ORCID: 0000-0002-7713-8804 AD - Indian Institute of Public Health, Bengaluru, India. FAU - Addanki, Srivalli AU - Addanki S AD - Indian Institute of Public Health, Bengaluru, India. FAU - Kurmi, Om AU - Kurmi O AD - Centre for Healthcare and Communities, Coventry University, Coventry, United Kingdom. FAU - Iyer, Gowri AU - Iyer G AD - Indian Institute of Public Health, Bengaluru, India. FAU - Kamalakannan, Sureshkumar AU - Kamalakannan S AD - Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. AD - School of Communities and Education, Northumbria University, Newcastle Upon Tyne, United Kingdom. FAU - Sadanand, Shilpa AU - Sadanand S AUID- ORCID: 0000-0002-2097-2187 AD - Indian Institute of Public Health, Bengaluru, India. FAU - Kulkarni, Bharati AU - Kulkarni B AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, India. AD - Indian Council of Medical Research, New Delhi, India. FAU - Kinra, Sanjay AU - Kinra S AD - Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. FAU - Mallinson, Poppy A C AU - Mallinson PAC AD - Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. LA - eng GR - WT_/Wellcome Trust/United Kingdom PT - Journal Article DEP - 20260730 PL - United States TA - PLOS Glob Public Health JT - PLOS global public health JID - 9918283779606676 PMC - PMC13422877 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/30 18:36 MHDA- 2026/07/30 18:37 PMCR- 2026/07/30 CRDT- 2026/07/30 13:43 PHST- 2025/08/11 00:00 [received] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/07/30 18:37 [medline] PHST- 2026/07/30 18:36 [pubmed] PHST- 2026/07/30 13:43 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - PGPH-D-25-01731 [pii] AID - 10.1371/journal.pgph.0006694 [doi] PST - epublish SO - PLOS Glob Public Health. 2026 Jul 30;6(7):e0006694. doi: 10.1371/journal.pgph.0006694. eCollection 2026. PMID- 42528895 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260730 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Predicting serum phosphate levels in very preterm infants using machine learning. PG - 1881474 LID - 10.3389/fped.2026.1881474 [doi] LID - 1881474 AB - BACKGROUND: Hypophosphatemia in very preterm and small for gestational age (SGA) infants is common and associated with serious complications. Diagnosis relies on phosphate concentrations, measured in serum or plasma. Machine learning (ML) may enable indirect estimation of serum phosphate based on routinely collected clinical data and results from blood gas analysis. OBJECTIVES: To (1) describe first week electrolyte trajectories in the ImNuT-trial (Clinicaltrials.gov ID: NCT03555019), and (2) develop and externally validate ML models to estimate serum phosphate levels during the first postnatal week in very preterm infants, using routinely collected clinical and nutritional data. METHODS: We performed a retrospective analysis of 120 infants born <29 weeks' gestation, all managed under a standardized nutritional protocol. Electrolyte trajectories (calcium, potassium, sodium, phosphate) were described using daily means stratified by hypophosphatemia and SGA status. For ML, we defined three regression tasks: concurrent phosphate prediction at blood gas analysis, and forecasts 12 h and 24 h ahead. Twenty-two candidate predictors from blood gases, anthropometry, SGA status and nutrient intakes were subjected to RENT-based variable selection within leave-one-group-out cross-validation. Multiple algorithms (elastic net, gradient boosting, random forests, k-nearest neighbours, kernel ridge, XGBoost) were trained under three preprocessing strategies (complete cases, complete cases without outliers, imputed data). Performance was evaluated with RMSE and R (2) using nested cross-validation and an independent external cohort of 40 very preterm infants. RESULTS: Among 119 infants with phosphate measurements (607 samples), 33.6% developed hypophosphatemia in week one. SGA infants had a markedly higher and earlier risk of hypophosphatemia compared to appropriate-for-gestational-age infants (log-rank p < 0.0001). Six predictors (calcium, potassium, gestational age, SGA status, birth weight z-score, daily weight z-score) were consistently retained across all prediction tasks. Elastic net models performed best externally on all three prediction tasks. Performance was robust across preprocessing strategies. CONCLUSIONS: SGA status is a major determinant of early hypophosphatemia risk in very preterm infants. ML models using routinely available clinical and nutritional data can moderately but consistently estimate serum phosphate levels, including 12-24 h ahead, and may serve as screening tools to guide nutritional management and reduce unnecessary blood sampling. Prospective validation is warranted before clinical implementation. CI - (c) 2026 Westvik, Tomic, Tscherning and Moltu. FAU - Westvik, Asbjorn S AU - Westvik AS AD - Institute of Clinical Medicine, University of Oslo, Oslo, Norway. AD - Department of Neonatal Intensive Care, Oslo University Hospital, Oslo, Norway. FAU - Tomic, Oliver AU - Tomic O AD - Faculty of Science and Technology, Norwegian University of Life Sciences, As, Norway. FAU - Tscherning, Charlotte AU - Tscherning C AD - Institute of Clinical Medicine, University of Oslo, Oslo, Norway. AD - Department of Neonatal Intensive Care, Oslo University Hospital, Oslo, Norway. FAU - Moltu, Sissel J AU - Moltu SJ AD - Department of Neonatal Intensive Care, Oslo University Hospital, Oslo, Norway. LA - eng SI - ClinicalTrials.gov/NCT03555019 PT - Journal Article DEP - 20260715 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13415508 OTO - NOTNLM OT - hypophosphatemia OT - machine learning OT - prediction model OT - preterm infant OT - refeeding syndrome COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/30 06:41 MHDA- 2026/07/30 06:42 PMCR- 2026/07/15 CRDT- 2026/07/30 04:48 PHST- 2026/05/14 00:00 [received] PHST- 2026/06/29 00:00 [revised] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/07/30 06:42 [medline] PHST- 2026/07/30 06:41 [pubmed] PHST- 2026/07/30 04:48 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - 10.3389/fped.2026.1881474 [doi] PST - epublish SO - Front Pediatr. 2026 Jul 15;14:1881474. doi: 10.3389/fped.2026.1881474. eCollection 2026. PMID- 42528788 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260813 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Prepregnancy body mass index and risk of macrosomia after fresh embryo transfer: a retrospective cohort study with exploratory threshold analysis. PG - 1884067 LID - 10.3389/fendo.2026.1884067 [doi] LID - 1884067 AB - BACKGROUND: Higher prepregnancy body mass index (BMI) is a well-established risk factor for adverse neonatal outcomes in IVF-conceived pregnancies; therefore, weight management is important for infertile patients, yet it remains challenging. Determining a clinically applicable BMI threshold for neonatal outcome risk assessment in fresh embryo transfer (fresh ET) cycles is meaningful; however, it remains undetermined. Therefore, this study aimed to identify an exploratory BMI threshold associated with increased risk of adverse neonatal outcomes after fresh ET, providing a preliminary reference for clinical risk communication. METHODS: This retrospective cohort study included 2,195 women who underwent autologous fresh ET between June 2019 and December 2023. Multivariable regression analysis examined the association between prepregnancy BMI and neonatal outcomes. Smooth curve fitting and threshold effect analysis identified the exploratory BMI threshold. Adjusted analysis following propensity score matching (PSM) was conducted as a sensitivity analysis to validate the robustness of the results. RESULTS: The multivariate regression analyses revealed that birthweight (adjusted beta: 22.63, 95% CI: 14.53 to 30.73; P<0.001) and Z-score (adjusted beta: 0.06, 95% CI: 0.04 to 0.08; P<0.001) were positively associated with increasing maternal BMI. Compared with the reference group (BMI 18.5-24.9 kg/m(2)), the incidence of macrosomia was increased by 2.25-fold in the BMI 25-29.9 kg/m(2) group (adjusted OR: 2.25, 95% CI: 1.29 to 3.93; P = 0.004) and by 4.56-fold in the BMI >/=30 kg/m(2) group (adjusted OR: 4.56, 95% CI: 2.26 to 9.22; P<0.001). Smooth curve fitting and threshold effect analysis revealed a significant increase in the odds of macrosomia when BMI exceeded 26.22 kg/m(2) (adjusted OR: 4.05, 95% CI: 2.47 to 7.29; P = 0.0009). PSM analysis confirmed that patients with a BMI >26.22 kg/m(2) (adjusted OR: 3.01, 95% CI: 2.02 to 4.47; P<0.001) had significantly higher odds of macrosomia compared to those with BMI .90, CV < 5%) repeatability, although the ASH test demonstrated good-to-excellent relative repeatability (ICC = .87-.90) but greater absolute variability (CV > 10%). CONCLUSION: CMJ and ballistic push-up testing on a force plate are suitable for athlete monitoring in competitive swimming. The ASH test demonstrated greater variability between sessions, highlighting the need for further evaluation prior to its integration into athlete monitoring assessments. FAU - McKenzie, Mark AU - McKenzie M AUID- ORCID: 0009-0005-7326-3535 AD - Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. AD - Integrative Neuromuscular Sport Performance Lab, Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. FAU - Boon-van Mossel, Nathan AU - Boon-van Mossel N AUID- ORCID: 0009-0007-2948-0131 AD - Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. AD - Integrative Neuromuscular Sport Performance Lab, Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. FAU - McClean, Zachary J AU - McClean ZJ AUID- ORCID: 0000-0002-7219-9448 AD - Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. AD - Integrative Neuromuscular Sport Performance Lab, Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. FAU - Jordan, Matthew J AU - Jordan MJ AUID- ORCID: 0000-0002-8044-1441 AD - Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. AD - Integrative Neuromuscular Sport Performance Lab, Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. AD - Sport Medicine Centre, University of Calgary, Calgary, AB, Canada. LA - eng PT - Journal Article DEP - 20260729 PL - United States TA - Int J Sports Physiol Perform JT - International journal of sports physiology and performance JID - 101276430 SB - IM MH - Humans MH - *Swimming/physiology/injuries MH - Female MH - Reproducibility of Results MH - *Muscle Strength/physiology MH - *Exercise Test/methods MH - Male MH - Young Adult MH - Canada MH - Return to Sport MH - *Shoulder/physiology MH - Universities MH - Adolescent OTO - NOTNLM OT - athletic shoulder test OT - countermovement jump OT - push-up OT - shoulder girdle OT - strength assessment EDAT- 2026/07/30 00:38 MHDA- 2026/09/29 19:03 CRDT- 2026/07/29 19:32 PHST- 2025/11/03 00:00 [received] PHST- 2026/04/01 00:00 [revised] PHST- 2026/04/10 00:00 [accepted] PHST- 2026/09/29 19:03 [medline] PHST- 2026/07/30 00:38 [pubmed] PHST- 2026/07/29 19:32 [entrez] AID - 10.1123/ijspp.2025-0499 [doi] PST - epublish SO - Int J Sports Physiol Perform. 2026 Jul 29;21(10):1198-1202. doi: 10.1123/ijspp.2025-0499. Print 2026 Oct 1. PMID- 42525094 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260923 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 8 DP - 2026 Jul 29 TI - Prospective association between baseline ultra-processed food consumption and future adherence to the 24-h movement guidelines in children: findings from the SENDO project. LID - 10.1007/s00431-026-07287-6 [doi] LID - 621 AB - This study evaluates whether baseline ultra-processed food (UPF) consumption predicts failure to meet 24-h movement guidelines at 2-year follow-up in early childhood. Data from 586 participants (aged 4-5 years at baseline) from the SENDO project were analyzed. Dietary intake was assessed through a validated 149-item FFQ, completed by parents, and categorized by NOVA classification. Physical activity, screen time, and sleep time were assessed through questionnaires, based on the 24-h movement guidelines established by the Canadian Society for Exercise Physiology and the WHO. Overall, 92.0% of participants adhered to at least one guideline, 38.9% met all three, and only 8.0% met none of the recommendations. After adjusting for confounders, children in the highest UPF tertile (T3) had a rate ratio (RR) of 1.27 (95% CI 1.04-1.55; p = 0.021) compared with the lowest (T1). A significant linear trend was observed across UPF tertiles (p for trend = 0.022). Moreover, children in T3 had a greater likelihood of not meeting the recreational screen time guideline (RR 1.82, 95% CI 1.18-2.64; p = 0.036) than those in T1. Absolute screen time was significantly higher in T3 than T1 (1.31 +/- 1.11 vs. 0.94 +/- 1.18 h/day; p < 0.001). CONCLUSION: This study suggests that higher UPF consumption is associated with a lower adherence to 24-h movement recommendations-specifically regarding an increased likelihood of not complying with the recreational screen time recommendation. This highlights the importance of reducing UPF intake to support healthy behaviors over time in early life. WHAT IS KNOWN: * Only a limited number of longitudinal studies have investigated the potential long-term association between dietary habits and the 24-h movement guidelines. * Higher consumption of ultra-processed foods (UPFs) is consistently linked to nutrient imbalances and adverse metabolic outcomes in children and adolescents. WHAT IS NEW: * This is the first study to prospectively investigate the relationship between early-life UPF intake and subsequent nonadherence to the 24-h movement guidelines in preschoolers. * Higher baseline UPF intake predicts a lower likelihood of meeting the movement recommendations after a 2-year follow-up, an association primarily driven by increased sedentary screen time. CI - (c) 2026. The Author(s). FAU - Paladino, Nadia AU - Paladino N AD - Department of Biomedical and Biotechnological Sciences, University of Catania, 95123, Catania, Italy. FAU - Martinez-Gonzalez, Miguel Angel AU - Martinez-Gonzalez MA AD - Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, 31008, Pamplona, Spain. AD - Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Navarra Institute for Health Research, 31008, Pamplona, Spain. AD - Biomedical Research Network Center for Pathophysiology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, 28029, Madrid, Spain. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AD - School of Medicine, Universidad Espiritu Santo, Samborondon, Ecuador. AD - Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno, Chile. FAU - Grosso, Giuseppe AU - Grosso G AD - Department of Biomedical and Biotechnological Sciences, University of Catania, 95123, Catania, Italy. FAU - Martin-Calvo, Nerea AU - Martin-Calvo N AD - Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, 31008, Pamplona, Spain. nmartincalvo@unav.es. AD - Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Navarra Institute for Health Research, 31008, Pamplona, Spain. nmartincalvo@unav.es. AD - Pathophysiology of Obesity and Nutrition, Centro de Investigacion Biomedica en Red, Instituto de Salud Carlos III, Madrid, Spain. nmartincalvo@unav.es. LA - eng PT - Journal Article DEP - 20260729 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Child, Preschool MH - Male MH - Female MH - Prospective Studies MH - *Fast Foods/statistics & numerical data/adverse effects MH - *Exercise MH - Screen Time MH - Surveys and Questionnaires MH - *Guideline Adherence/statistics & numerical data MH - Sleep Duration MH - Sedentary Behavior MH - Follow-Up Studies PMC - PMC13421281 OTO - NOTNLM OT - Diet OT - Physical activity OT - Preschoolers OT - Screen time OT - Sedentary behavior OT - Sleep duration COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/07/29 13:54 MHDA- 2026/07/29 13:55 PMCR- 2026/07/29 CRDT- 2026/07/29 11:04 PHST- 2026/01/24 00:00 [received] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/07/21 00:00 [revised] PHST- 2026/07/29 13:55 [medline] PHST- 2026/07/29 13:54 [pubmed] PHST- 2026/07/29 11:04 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - 10.1007/s00431-026-07287-6 [pii] AID - 7287 [pii] AID - 10.1007/s00431-026-07287-6 [doi] PST - epublish SO - Eur J Pediatr. 2026 Jul 29;185(8):621. doi: 10.1007/s00431-026-07287-6. PMID- 42525014 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260918 IS - 1980-5497 (Electronic) IS - 1415-790X (Print) IS - 1415-790X (Linking) VI - 29 DP - 2026 TI - Risk and Protective Factor Indicators Management Committee: methodological approach in the construction of indicators of the interagency health information network (Ripsa), 2023. PG - e260026 LID - S1415-790X2026000101025 [pii] LID - 10.1590/1980-549720260026 [doi] LID - e260026 AB - OBJECTIVE: To describe the role of the Risk and Protective Factors Indicator Management Committee (RPF CGI) in the resumption and update of the Interagency Health Information Network (Rede Interagencial de Informacoes para a Saude - Ripsa) indicator matrix in 2023, highlighting the sustainability of data sources and validation processes. METHODS AND RESULTS: Interinstitutional technical meetings were held between 2023 and 2025, involving 36 institutions, to review, define, and validate the indicators using a standardized indicator qualification form. A consensus was reached to use data from the Surveillance System for Risk and Protective Factors for Chronic Diseases by Telephone Survey (Sistema de Vigilancia de Fatores de Risco e Protecao para Doencas Cronicas por Inquerito Telefonico - Vigitel), National Study of Infant Feeding and Nutrition (Estudo Nacional de Alimentacao e Nutricao Infantil - Enani), Live Birth Information System (Sistema de Informacoes sobre Nascidos Vivos - Sinasc), National Health Survey (Pesquisa Nacional de Saude - PNS), Household Budget Survey (Pesquisa de Orcamentos Familiares - POF), National School Health Survey (Pesquisa Nacional de Saude do Escolar - PeNSE), National Demographic and Health Survey (Pesquisa Nacional de Demografia e Saude - PNDS), Annual Industrial Survey - Product (Pesquisa Industrial Anual - Produto - PIA-Produto), National Survey on Health and Nutrition (Pesquisa Nacional sobre Saude e Nutricao - PNSN), and National Oral Health Survey (Pesquisa Nacional de Saude Bucal - SB Brasil). The matrix was expanded to 39 indicators, distributed across nine dimensions: noncommunicable chronic diseases, alcohol consumption, smoking, physical activity, nutritional status, dietary intake, childbirth, violence, and oral health. CONCLUSION: The RPF CGI contributed to the qualification and sustainability of Ripsa indicators, which are essential for monitoring public policies, supporting evidence-based decision-making, and addressing health inequalities, aligning with national and international agendas such as the Sustainable Development Goals. FAU - Malta, Deborah Carvalho AU - Malta DC AUID- ORCID: 0000-0002-8214-5734 AD - Universidade Federal de Minas Gerais, School of Nursing, Department of Maternal-Child Nursing and Public Health - Belo Horizonte (MG), Brazil. FAU - Oliveira, Max Moura de AU - Oliveira MM AUID- ORCID: 0000-0002-0804-5145 AD - Universidade Federal de Goias, Instituto de Patologia Tropical e Saude Publica, Department of Collective Health - Goias (GO), Brazil. FAU - Freitas, Mariana Goncalves de AU - Freitas MG AUID- ORCID: 0000-0002-6679-032X AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Antunes, Anna Beatriz Souza AU - Antunes ABS AUID- ORCID: 0000-0001-7813-5421 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Ricardo, Leticia Mendes AU - Ricardo LM AUID- ORCID: 0009-0005-7137-2375 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Tierling, Vera Lucia AU - Tierling VL AUID- ORCID: 0000-0001-9856-2017 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Santos, Debora Franca Dos AU - Santos DFD AUID- ORCID: 0000-0003-3917-2291 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Freitas, Paula Carvalho de AU - Freitas PC AUID- ORCID: 0000-0002-3737-2962 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Oliveira Baldi, Flora Vitoria Serena AU - Oliveira Baldi FVS AUID- ORCID: 0009-0006-7619-1415 AD - Universidade Federal de Minas Gerais, School of Nursing - Belo Horizonte (MG), Brazil. FAU - Carrato, Barbara Aguiar AU - Carrato BA AUID- ORCID: 0000-0001-8102-5741 AD - Universidade Federal de Minas Gerais, School of Nursing - Belo Horizonte (MG), Brazil. FAU - Ferreira, Ana Lorena Lima AU - Ferreira ALL AUID- ORCID: 0000-0003-4236-2651 AD - Ministry of Health, Secretariat of Primary Health Care - Brasilia (DF), Brazil. FAU - Santos, Thanise Sabrina Souza AU - Santos TSS AUID- ORCID: 0000-0003-4087-1815 AD - Ministry of Health, Secretariat of Primary Health Care - Brasilia (DF), Brazil. FAU - Oliveira, Gabriela AU - Oliveira G AUID- ORCID: 0000-0002-2403-5094 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Silva, Isabela da Costa Gaspar da AU - Silva IDCGD AUID- ORCID: 0000-0001-7329-3527 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Menezes-Junior, Luiz Antonio Alves de AU - Menezes-Junior LAA AUID- ORCID: 0000-0002-4497-5358 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Moraes, Luci Fabiane Scheffer AU - Moraes LFS AUID- ORCID: 0000-0003-1034-3878 AD - Ministry of Health, Secretariat of Information and Digital Health - Brasilia (DF), Brazil. CN - Management Committee on Risk and Protective Factors Indicators FAU - Gomes, Gabriella Farias AU - Gomes GF AUID- ORCID: 0000-0001-9118-9694 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Gomes, Julia do Amaral AU - Gomes JA AUID- ORCID: 0000-0001-0002-0003 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Konstantyner, Tulio AU - Konstantyner T AUID- ORCID: 0000-0002-7931-9692 AD - Universidade Federal de Sao Paulo - Sao Paulo (SP), Brazil. FAU - Boing, Alexandra Crispim AU - Boing AC AUID- ORCID: 0000-0001-7792-4824 AD - Universidade Federal de Santa Catarina - Florianopolis (SC), Brazil. FAU - Lara, Joao Victor Ingles de AU - Lara JVI AUID- ORCID: 0000-0001-7079-246X AD - Ministry of Health, Secretariat of Primary Health Care, General Coordination of Oral Health - Brasilia (DF), Brazil FAU - Alves, Luciana Correia AU - Alves LC AUID- ORCID: 0000-0002-8598-4875 AD - Associacao Brasileira de Estudos Populacionais - Campinas (SP), Brazil. FAU - Silva, Josy Maria de Pinho da AU - Silva JMP AUID- ORCID: 0000-0002-7187-1028 AD - World Health Organization, Pan American Health Organization - Brasilia (DF), Brazil. FAU - Szklo, Andre Salem AU - Szklo AS AUID- ORCID: 0000-0003-1903-6188 AD - Instituto Nacional de Cancer - Rio de Janeiro (RJ), Brazil. FAU - Pavao, Ana Luiza Braz AU - Pavao ALB AUID- ORCID: 0000-0002-4122-1796 AD - Fundacao Oswaldo Cruz, Instituto de Comunicacao e Informacao Cientifica e Tecnologica em Saude - Rio de Janeiro (RJ), Brazil. FAU - Fernandes, Hugo AU - Fernandes H AUID- ORCID: 0000-0003-2380-2914 AD - Universidade Federal de Sao Paulo - Sao Paulo (SP), Brazil. FAU - Araujo, Marina Campos AU - Araujo MC AUID- ORCID: 0000-0002-7980-6618 AD - Fundacao Oswaldo Cruz, Instituto de Comunicacao e Informacao Cientifica e Tecnologica em Saude - Rio de Janeiro (RJ), Brazil. FAU - Falcao, Kandice de Melo AU - Falcao KM AUID- ORCID: 0000-0002-6725-6110 AD - Conselho Nacional de Secretarias Municipais de Saude - Brasilia (DF), Brazil. FAU - Marque, Emanuele Souza AU - Marque ES AUID- ORCID: 0000-0002-8633-7290 AD - Universidade do Estado do Rio de Janeiro, Instituto de Medicina Social Hesio Cordeiro - Rio de Janeiro (RJ), Brazil. FAU - Levy, Renata Bertazzi AU - Levy RB AUID- ORCID: 0000-0001-5388-7002 AD - Universidade de Sao Paulo, Faculdade de Medicina - Sao Paulo (SP), Brazil. FAU - Carneiro, Joana Danielle Brandao AU - Carneiro JDB AUID- ORCID: 0000-0003-3629-8091 AD - Ministry of Health, Secretariat of Primary Health Care, Secretariat of Primary Health Care - Brasilia (DF), Brazil. FAU - Carvasan, Gislaine Aparecida Fonsechi AU - Carvasan GAF AUID- ORCID: 0000-0002-1668-9856 AD - Universidade Estadual de Campinas - Campinas (SP), Brazil. FAU - Sampaio, Aline Fernanda Silva AU - Sampaio AFS AUID- ORCID: 0000-0002-9805-2946 AD - Universidade Federal do Acre - Rio Branco (AC), Brazil. FAU - Nunes, Monica da Silva AU - Nunes MS AUID- ORCID: 0000-0002-5078-9121 AD - Universidade Federal de Sao Carlos - Sao Carlos (SP), Brazil. FAU - Boni, Raquel Brandini De AU - Boni RB AUID- ORCID: 0000-0002-2455-5997 AD - Fundacao Oswaldo Cruz, Instituto de Comunicacao e Informacao Cientifica e Tecnologica em Saude - Rio de Janeiro (RJ), Brazil. FAU - Gomes, Crizian Saar AU - Gomes CS AUID- ORCID: 0000-0001-6586-4561 AD - Universidade Federal de Minas Gerais - Belo Horizonte (MG), Brazil. FAU - Boing, Antonio Fernando AU - Boing AF AUID- ORCID: 0000-0001-9331-1550 AD - Universidade Federal de Santa Catarina - Florianopolis (SC), Brazil FAU - Sousa, Juliana Lourenco AU - Sousa JL AUID- ORCID: 0009-0000-4220-128X AD - World Health Organization, Pan American Health Organization, Centro Latino-Americano e do Caribe de Informacao em Ciencias da Saude - Sao Paulo (SP), Brazil. FAU - Gomes, Marilia Miranda Forte AU - Gomes MMF AUID- ORCID: 0000-0001-8584-9676 AD - Associacao Brasileira de Estudos Populacionais - Campinas (SP), Brazil. FAU - Mello, Marcia Sarpa de Campos AU - Mello MSC AUID- ORCID: 0000-0001-8976-4653 AD - Instituto Nacional de Cancer - Rio de Janeiro (RJ), Brazil. FAU - Andrade, Joanlise Marco de Leon AU - Andrade JML AUID- ORCID: 0000-0002-3984-3799 AD - Universidade de Brasilia - Brasilia (DF), Brazil. FAU - Bousquet-Santos, Kelb AU - Bousquet-Santos K AUID- ORCID: 0000-0002-4687-4681 AD - Universidade de Brasilia - Brasilia (DF), Brazil. FAU - Lima, Everton Emanuel Campos de AU - Lima EEC AUID- ORCID: 0000-0001-6275-9854 AD - Universidade Estadual de Campinas - Campinas (SP), Brazil. FAU - Henrique, Rafael dos Santos AU - Henrique RS AUID- ORCID: 0000-0003-3912-5559 AD - Universidade Federal de Pernambuco - Recife (PE), Brazil. LA - eng LA - por PT - Journal Article DEP - 20260727 PL - Brazil TA - Rev Bras Epidemiol JT - Revista brasileira de epidemiologia = Brazilian journal of epidemiology JID - 100954576 SB - IM MH - Humans MH - Brazil MH - Risk Factors MH - *Health Status Indicators MH - *Health Information Systems/organization & administration PMC - PMC13405555 COIS- CONFLICT OF INTERESTS: nothing to declare EDAT- 2026/07/29 13:54 MHDA- 2026/07/29 13:55 PMCR- 2026/07/27 CRDT- 2026/07/29 11:03 PHST- 2025/12/10 00:00 [received] PHST- 2026/03/13 00:00 [accepted] PHST- 2026/07/29 13:55 [medline] PHST- 2026/07/29 13:54 [pubmed] PHST- 2026/07/29 11:03 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - S1415-790X2026000101025 [pii] AID - 10.1590/1980-549720260026 [doi] PST - epublish SO - Rev Bras Epidemiol. 2026 Jul 27;29:e260026. doi: 10.1590/1980-549720260026. eCollection 2026. PMID- 42524052 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 0974-7052 (Print) IS - 0975-1904 (Electronic) IS - 0974-7052 (Linking) VI - 19 IP - 6 DP - 2026 Jun TI - Evaluation of Screen Time, Oral Health Status, and Sleep Disturbances in Children between 6 and 13 years: A Cross-sectional Study. PG - 711-717 LID - 10.5005/jp-journals-10005-3538 [doi] AB - BACKGROUND: Sleep is a critical component required for the growth and development of a child. Deviation from the normal sleep pattern, quality, and quantity directly affects the baseline functioning of the individual. Increased screen time exposure affects the overall well-being of the child, particularly the sleep and oral health. AIM: To assess the average screen time exposure, oral health status, and prevalence of sleep disorders in children between 6 and 13 years of age. MATERIALS AND METHODS: This cross-sectional study included 370 children visiting the Department of Pediatric and Preventive Dentistry between July 2024 and January 2025. Data were collected using a validated screen time questionnaire and the Sleep Disturbance Scale for Children. Dental caries was assessed using the ICDAS II index. The descriptive statistics were reported in the form of mean and standard deviation. ANOVA, bivariate, and multivariate linear regression analyses were performed. Statistical significance was noted when the p-value was 0.90), including parent-reported toe-walking percentage, satisfaction, treatment adherence, pain-on-activity, and clinician-reported gait scale. Validity analyses showed significant and meaningful correlations between iTWO proforma-T items and established measures. The estimated toe-walking percentage correlated strongly with the Toe Walking Severity Scale (rho = -0.549) and the OxAFQ emotional domain (rho = -0.493). Functional performance items (gait scale, 2- and 6-minute walk tests) showed moderate positive correlations with toe-walking severity, whereas pain-related items correlated negatively with relevant PODCI and OxAFQ domains. CONCLUSION: The iTWO proforma-T is a valid and reliable instrument for evaluating symptoms, functional status, and treatment-related outcomes in children with idiopathic toe walking. The tool preserves the structure and measurement characteristics of the original proforma and can be confidently used by clinicians and researchers for evidence-based assessment and follow-up in Turkish-speaking pediatric populations. CI - (c) 2026 The Author(s). Journal of Foot and Ankle Research published by John Wiley & Sons Australia, Ltd on behalf of Australian Podiatry Association and The Royal College of Podiatry. FAU - Giray, Esra AU - Giray E AUID- ORCID: 0000-0003-3895-4486 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye. FAU - Karadag, Munteha Ilkyaz AU - Karadag MI AUID- ORCID: 0009-0001-6500-3072 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkiye. FAU - Turkyilmaz, Sude Gozukucuk AU - Turkyilmaz SG AUID- ORCID: 0009-0008-2381-4089 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye. FAU - Celik, Kubra Yildiz AU - Celik KY AUID- ORCID: 0009-0002-1920-5682 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye. FAU - Akpinar, Pinar AU - Akpinar P AUID- ORCID: 0000-0002-7796-0750 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye. FAU - Illeez, Ozge Gulsum AU - Illeez OG AUID- ORCID: 0000-0002-3824-4428 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye. FAU - Unlu Ozkan, Feyza AU - Unlu Ozkan F AUID- ORCID: 0000-0002-7686-1347 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye. FAU - Aktas, Ilknur AU - Aktas I AUID- ORCID: 0000-0002-1050-9666 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye. FAU - Karadag-Saygi, Evrim AU - Karadag-Saygi E AUID- ORCID: 0000-0002-7420-9902 AD - Department of Physical Medicine and Rehabilitation, Marmara University School of Medicine, Istanbul, Turkiye. FAU - Williams, Cylie M AU - Williams CM AUID- ORCID: 0000-0002-0223-9141 AD - School of Primary and Allied Health Care, Monash University, Peninsula Campus, Frankston, Victoria, Australia. LA - eng PT - Journal Article PT - Validation Study PL - United States TA - J Foot Ankle Res JT - Journal of foot and ankle research JID - 101471610 SB - IM MH - Humans MH - Child MH - Reproducibility of Results MH - Female MH - Child, Preschool MH - Male MH - Adolescent MH - *Toes/physiopathology MH - Turkey MH - *Walking/physiology MH - Surveys and Questionnaires MH - Severity of Illness Index MH - Psychometrics MH - *Movement Disorders/physiopathology/diagnosis MH - Treatment Outcome PMC - PMC13415977 OTO - NOTNLM OT - 6-minute walk test OT - Toe Walking Severity Scale OT - idiopathic toe walking OT - treatment outcomes OT - weight-bearing lunge COIS- The authors declare no conflicts of interest. EDAT- 2026/07/29 06:35 MHDA- 2026/07/29 18:39 PMCR- 2026/07/28 CRDT- 2026/07/29 01:43 PHST- 2026/07/07 00:00 [revised] PHST- 2026/02/16 00:00 [received] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/07/29 18:39 [medline] PHST- 2026/07/29 06:35 [pubmed] PHST- 2026/07/29 01:43 [entrez] PHST- 2026/07/28 00:00 [pmc-release] AID - JFA270188 [pii] AID - 10.1002/jfa2.70188 [doi] PST - ppublish SO - J Foot Ankle Res. 2026 Sep;19(3):e70188. doi: 10.1002/jfa2.70188. PMID- 42521910 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260819 IS - 1539-0829 (Electronic) IS - 1534-4827 (Print) IS - 1534-4827 (Linking) VI - 26 IP - 1 DP - 2026 Jul 29 TI - Insulin-Related Disordered Eating Behaviour: A Scoping Review of Evidence. LID - 10.1007/s11892-026-01637-2 [doi] LID - 23 AB - PURPOSE OF REVIEW: Current understanding of insulin-related disordered eating behaviour is limited by inconsistencies in terminology and measurement. Prevalence of the behaviour and characteristics of individuals are unclear. How best to intervene and with whom is therefore unknown. This scoping review summarises existing knowledge as a first step to addressing the problem. Eligible sources investigated individuals with T1D restricting or inflating insulin with disordered eating motivations. Charted data included study aims, sample characteristics, measures, and key findings. RECENT FINDINGS: Samples converged on adolescent females in USA, Canada and western Europe. Numerous measures were used, few had received extensive validation. Prevalence estimates, and models of development and maintenance were inconsistent. The validity and generalisability of measures should be improved, particularly so that diverse perspectives (e.g., males, non-Western cultures), so far overlooked, are captured. Identity and social relationships appeared particularly important in the development and maintenance of insulin-related disordered eating behaviour and recovery, and could be a potential target for interventions. CI - (c) 2026. The Author(s). FAU - Shelford, Amy AU - Shelford A AUID- ORCID: 0000-0002-2666-1144 AD - School of Psychology and Clinical Language Sciences, University of Reading, Whiteknights Campus, RG6 6ES, Reading, England. a.shelford@pgr.reading.ac.uk. FAU - Jenkins, Paul E AU - Jenkins PE AUID- ORCID: 0000-0003-1673-2903 AD - School of Psychology and Clinical Language Sciences, University of Reading, Whiteknights Campus, RG6 6ES, Reading, England. FAU - Harvey, Kate AU - Harvey K AUID- ORCID: 0000-0002-6819-0934 AD - School of Psychology and Clinical Language Sciences, University of Reading, Whiteknights Campus, RG6 6ES, Reading, England. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260729 PL - United States TA - Curr Diab Rep JT - Current diabetes reports JID - 101093791 RN - 0 (Insulin) SB - IM MH - Humans MH - *Feeding and Eating Disorders/epidemiology/chemically induced/psychology MH - *Insulin/adverse effects/administration & dosage MH - Female MH - *Diabetes Mellitus, Type 1/drug therapy/psychology MH - *Feeding Behavior/psychology PMC - PMC13415336 OTO - NOTNLM OT - Type 1 diabetes OT - insulin inflation OT - insulin restriction OT - insulin-related disordered eating behaviour COIS- Declarations. Human or Animal Rights: This article does not contain any studies with human or animal subjects performed by any of the authors. Competing interests: The authors declare no competing interests. EDAT- 2026/07/29 00:35 MHDA- 2026/07/29 18:39 PMCR- 2026/07/29 CRDT- 2026/07/28 23:23 PHST- 2025/09/17 00:00 [received] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/07/29 18:39 [medline] PHST- 2026/07/29 00:35 [pubmed] PHST- 2026/07/28 23:23 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - 10.1007/s11892-026-01637-2 [pii] AID - 1637 [pii] AID - 10.1007/s11892-026-01637-2 [doi] PST - epublish SO - Curr Diab Rep. 2026 Jul 29;26(1):23. doi: 10.1007/s11892-026-01637-2. PMID- 42520924 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261022 IS - 2210-741X (Electronic) IS - 2210-7401 (Linking) VI - 50 IP - 8 DP - 2026 Oct TI - Sarcopenia in decompensated cirrhosis: a comparative analysis of bioelectrical impedance-based measures. PG - 102893 LID - S2210-7401(26)00139-7 [pii] LID - 10.1016/j.clinre.2026.102893 [doi] AB - BACKGROUND: Sarcopenia is highly prevalent in decompensated cirrhosis and strongly associated with adverse clinical outcomes. While bioelectrical impedance analysis (BIA) offers multiple body composition indices, the optimal approach remains uncertain. AIM: To evaluate the prevalence and comparative prognostic performance of Phase Angle (PA) versus other BIA-derived sarcopenia indices in patients with decompensated cirrhosis. METHODS: This prospective observational study included 155 patients with decompensated cirrhosis and ascites who underwent multi-frequency BIA. Sarcopenia was defined using sex-specific cutoffs for PA and four additional BIA-derived indices. Prognostic associations with mortality and infections were assessed through fully adjusted logistic and Cox regression models. RESULTS: Sarcopenia prevalence ranged between 40% and 50% across indices in the primary analysis. Although prevalence estimates were comparable, PA demonstrated superior prognostic performance. Low PA was independently associated with increased 12-month mortality (OR 2.28, 95% CI 1.52-3.42; p < 0.001) and infection risk (OR 1.95, 95% CI 1.32-2.88; p = 0.001), outperforming mass-based indices even after extensive adjustment. Each 1 degrees increase in PA was associated with a 29% reduction in mortality risk (HR 0.71, 95% CI 0.55-0.91; p = 0.008). These associations remained consistent across clinically relevant subgroups, including different ascites severities, Child-Pugh classes, and HCC status. PA also strongly predicted 90-day mortality and hospital readmissions. CONCLUSIONS: In patients with decompensated cirrhosis, PA provides significant added prognostic value beyond traditional BIA-derived muscle mass indices. This readily available bedside parameter may enhance risk stratification and support individualized nutritional and rehabilitative interventions. Its incremental utility warrants further validation in larger multicenter studies. CI - Copyright (c) 2026 Elsevier Masson SAS. All rights reserved. FAU - Elsabaawy, Maha AU - Elsabaawy M AD - Hepatology and Gastroenterology Department, National Liver Institute Menoufia University, Shebeen Elkoom, Egypt; Therapeutic Nutrition Department, National Liver Institute Menoufia University, Shebeen Elkoom, Egypt. Electronic address: maha.ahmed@liver.menofia.edu.eg. FAU - Ragab, Mohammed AU - Ragab M AD - Hepatology and Gastroenterology Department, National Liver Institute Menoufia University, Shebeen Elkoom, Egypt. FAU - Al-Khalifa, Maymona AU - Al-Khalifa M AD - Therapeutic Nutrition Department, National Liver Institute Menoufia University, Shebeen Elkoom, Egypt. FAU - Gamil, Khaled AU - Gamil K AD - Hepatology and Gastroenterology Department, National Liver Institute Menoufia University, Shebeen Elkoom, Egypt. FAU - Elfayoumy, Marwa AU - Elfayoumy M AD - Hepatology and Gastroenterology Department, National Liver Institute Menoufia University, Shebeen Elkoom, Egypt; Therapeutic Nutrition Department, National Liver Institute Menoufia University, Shebeen Elkoom, Egypt. LA - eng PT - Comparative Study PT - Journal Article PT - Observational Study DEP - 20260728 PL - France TA - Clin Res Hepatol Gastroenterol JT - Clinics and research in hepatology and gastroenterology JID - 101553659 SB - IM MH - Humans MH - *Sarcopenia/epidemiology/diagnosis/etiology/complications MH - *Electric Impedance MH - Female MH - *Liver Cirrhosis/complications/mortality MH - Male MH - Prospective Studies MH - Prognosis MH - Middle Aged MH - Prevalence MH - Aged MH - Ascites OTO - NOTNLM OT - Bioelectrical impedance analysis OT - Decompensated cirrhosis OT - Phase angle OT - Prognosis OT - Sarcopenia COIS- Declaration of competing interest The authors have no relevant financial or non-financial interests to disclose. EDAT- 2026/07/29 00:35 MHDA- 2026/10/16 23:33 CRDT- 2026/07/28 19:18 PHST- 2026/02/27 00:00 [received] PHST- 2026/07/23 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/10/16 23:33 [medline] PHST- 2026/07/29 00:35 [pubmed] PHST- 2026/07/28 19:18 [entrez] AID - S2210-7401(26)00139-7 [pii] AID - 10.1016/j.clinre.2026.102893 [doi] PST - ppublish SO - Clin Res Hepatol Gastroenterol. 2026 Oct;50(8):102893. doi: 10.1016/j.clinre.2026.102893. Epub 2026 Jul 28. PMID- 42520891 OWN - NLM STAT- MEDLINE DCOM- 20261020 LR - 20261020 IS - 2212-2672 (Print) IS - 2212-2672 (Linking) VI - 126 IP - 11 DP - 2026 Nov TI - Reliability and Validity of a Parent-Reported Diet Quality Screener for Young Children: The Rapid Prime Diet Quality Score for Kids. PG - 156425 LID - S2212-2672(26)00140-1 [pii] LID - 10.1016/j.jand.2026.156425 [doi] AB - BACKGROUND: Pediatric dietary assessment is challenging, particularly for young children who cannot accurately report their own intake. Many existing measures are burdensome for proxy-reporters, and briefer dietary screeners focus on specific dietary components but not total diet quality. OBJECTIVE: The objective of this study was to develop and evaluate the reliability and validity of an adapted brief parent-reported diet quality screener; that is, the rapid Prime Diet Quality Score for Kids (rPDQS-Kids), in relation to food groups and overall diet quality estimated from repeated Automated Self-Administered 24-Hour Dietary Assessment Tool (ASA24) diet recalls for young children. DESIGN: This was a cross-sectional study that evaluated the psychometric properties of the 16-item rPDQS-Kids. PARTICIPANTS/SETTING: Participants of this study included parents of children aged 1 to 4 years participating in the Special Supplemental Nutrition Program for Women, Infants, and Children (N = 175) in the state of Massachusetts from January 2024 to February 2025. MAIN OUTCOME MEASURES: Information about consumption frequencies was reported by parents using the rPDQS-Kids screener. Mean intake and overall diet quality were also assessed using 2 24-hour recalls. STATISTICAL ANALYSES PERFORMED: Test-retest reliability and internal consistency of the rPDQS-Kids were evaluated. Criterion validity was assessed by comparing the rPDQS-Kids diet quality score with the Healthy Eating Index (HEI) score (HEI-2020 for children aged 2 to 4 years or HEI-Toddlers-2020 for children aged 1 up to 2 years). RESULTS: The rPDQS-Kids showed moderate test-retest reliability (intraclass correlation coefficient for total score 0.69; 95% CI, 0.62 to 0.75). Consistent with a priori hypotheses, internal consistency reliability was low, with ordinal alpha = .27 and ordinal alpha = .34 for the healthy and unhealthy subscores, respectively. Further, a significant correlation was observed between the rPDQS-Kids traffic light diet quality score and HEI-2020 total score among children aged 2 to 4 years (r = 0.32) (P < .001) (n = 127). Among children aged 1 to 2 years (n = 48), rPDQS-Kids was not significantly correlated with the HEI-Toddlers-2020 (P > .05). CONCLUSIONS: The parent-reported rPDQS-Kids shows potential as a low-burden tool for measuring young children's dietary quality. CI - Copyright (c) 2026 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved. FAU - Hammad, Nour M AU - Hammad NM AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Electronic address: nourhammad@fas.harvard.edu. FAU - Zimmer, Meghan AU - Zimmer M AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. FAU - Mozaffarian, Rebecca S AU - Mozaffarian RS AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. FAU - Rimm, Eric B AU - Rimm EB AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. FAU - Kenney, Erica L AU - Kenney EL AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. LA - eng PT - Journal Article PT - Validation Study DEP - 20260728 PL - United States TA - J Acad Nutr Diet JT - Journal of the Academy of Nutrition and Dietetics JID - 101573920 SB - IM MH - Humans MH - Female MH - Reproducibility of Results MH - Child, Preschool MH - Cross-Sectional Studies MH - Infant MH - Parents MH - Male MH - *Nutrition Assessment MH - *Diet/statistics & numerical data/standards MH - Psychometrics MH - *Diet Surveys/methods/standards MH - Massachusetts MH - *Diet, Healthy/statistics & numerical data MH - Mental Recall OTO - NOTNLM OT - Diet quality OT - Dietary assessment OT - PDQS OT - Preschool-aged children OT - WIC EDAT- 2026/07/29 00:35 MHDA- 2026/10/20 23:28 CRDT- 2026/07/28 19:18 PHST- 2025/05/01 00:00 [received] PHST- 2026/07/01 00:00 [revised] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/10/20 23:28 [medline] PHST- 2026/07/29 00:35 [pubmed] PHST- 2026/07/28 19:18 [entrez] AID - S2212-2672(26)00140-1 [pii] AID - 10.1016/j.jand.2026.156425 [doi] PST - ppublish SO - J Acad Nutr Diet. 2026 Nov;126(11):156425. doi: 10.1016/j.jand.2026.156425. Epub 2026 Jul 28. PMID- 42519260 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 6 DP - 2026 Jun TI - Admission Respiratory Rate-Oxygenation Index and Outcome of Acute Respiratory Illness in a Pediatric Intensive Care Unit. PG - e111005 LID - 10.7759/cureus.111005 [doi] LID - e111005 AB - Background Acute respiratory illness (ARI) remains a leading cause of pediatric intensive care unit (PICU) admissions and mortality in low- and middle-income countries. Early identification of children at risk of deterioration or ventilatory support is essential to improve outcomes. The Respiratory Rate-Oxygenation (ROX) Index, defined as (peripheral oxygen saturation (SpO(2))/fraction of inspired oxygen (FiO(2)))/respiratory rate, is a non-invasive bedside tool validated in adults with respiratory failure; however, pediatric evidence is scarce. Objectives To evaluate the association of admission ROX Index with (1) mortality and (2) the requirement for positive-pressure ventilation (PPV) among children with ARI admitted to the PICU. Methods A prospective observational study was conducted among 200 consecutively admitted children aged two months to five years with ARI at a tertiary-care hospital. Demographic, anthropometric, and physiological parameters were recorded at admission. The ROX index was computed as (SpO(2)/FiO(2))/respiratory rate. Primary outcomes were in-hospital mortality and need for PPV. Data were analyzed using non-parametric tests and receiver operating characteristic (ROC) analysis; p<0.05 was considered significant (STATA v14; StataCorp LLC, College Station, TX, US). Results The median age was seven months (IQR 4-12); 131 (65.5%) were male patients, and severe undernutrition (weight-for-age Z-score <-3 SD) was observed in 36 (18%) children. Overall mortality was 7% (14/200). The median admission ROX index was lower among non-survivors (5.6 (5.2-6.4)) than survivors (6.3 (5.9-7.1); p=0.002). The ROX index showed moderate discrimination for mortality (AUC=0.746; 95% CI 0.62-0.87) with an optimal cut-off 0.05). SHAP and TabNet analyses highlighted screen time, sleep duration, parental obesity, physical activity and diet as key predictors. CONCLUSION: The GenAI-enhanced stacking ensemble model accurately predicts adolescent obesity, with strong calibration and interpretability. It identifies behavioural and familial determinants, supporting school and community deployment for early detection and prevention. CI - Copyright (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. Published by BMJ Group. FAU - Rakshitha, Jayashankar AU - Rakshitha J AUID- ORCID: 0000-0002-2011-1790 AD - Department Of Community Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. FAU - Sunil Kumar, Doddaiah AU - Sunil Kumar D AUID- ORCID: 0000-0001-8755-3975 AD - Department Of Community Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. FAU - Santhosh Kumar, M AU - Santhosh Kumar M AD - Department of Pediatrics, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. FAU - Arun, Vanishri AU - Arun V AD - Department of Information Science and Engineering, JSS Science and Technology University, Mysuru, Karnataka, India. FAU - Krishnamurthy, Kamidi Venkatesh AU - Krishnamurthy KV AUID- ORCID: 0000-0003-4433-8567 AD - Department Of Community Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. LA - eng PT - Journal Article DEP - 20260723 PL - England TA - BMJ Public Health JT - BMJ public health JID - 9918697578906676 PMC - PMC13405018 OTO - NOTNLM OT - Adolescent OT - Body Mass Index OT - Obesity OT - Risk Assessment COIS- None declared. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/23 CRDT- 2026/07/28 04:39 PHST- 2025/12/02 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 04:39 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - bmjph-2025-004650 [pii] AID - 10.1136/bmjph-2025-004650 [doi] PST - epublish SO - BMJ Public Health. 2026 Jul 23;4(3):e004650. doi: 10.1136/bmjph-2025-004650. eCollection 2026. PMID- 42516461 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260927 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 6 DP - 2026 Jun TI - Intimate Partner Violence and Childhood Nutritional Outcomes in Madhya Pradesh: Secondary Analysis of National Family Health Survey-5 (NFHS-5) Data. PG - e111586 LID - 10.7759/cureus.111586 [doi] LID - e111586 AB - BACKGROUND: Intimate partner violence (IPV) and childhood undernutrition represent co-occurring public health challenges in Madhya Pradesh (MP), India. This study examined the association between maternal IPV exposure and child health outcomes, including stunting, wasting, and underweight, using data from the National Family Health Survey-5 (NFHS-5), 2019-21. METHOD: A cross-sectional secondary data analysis was conducted using NFHS-5 Individual Recode and Children's Recode files for MP. The files were merged at the household level, yielding 1,820 mother-child pairs. IPV was assessed using the validated domestic violence (DV) module (n=4,519 women in the 50% subsample). Child outcomes were defined using WHO anthropometric Z-scores. Multivariable binary logistic regression estimated adjusted odds ratios (aOR) with 95% confidence intervals (CIs), adjusting for exogenous sociodemographic confounders, including place of residence, maternal education, wealth index, and maternal age. Demographic and Health Surveys (DHS) sampling weights were applied throughout. RESULTS: IPV prevalence was 28.3% among the DV subsample. Stunting, wasting, and underweight were observed in 36.4%, 18.7%, and 33.4% of children, respectively. After adjustment, IPV was not independently associated with stunting (aOR=1.071, 95% CI: 0.833-1.376, p=0.592), wasting (aOR=0.825, 95% CI: 0.601-1.132, p=0.234), or underweight (aOR=0.912, 95% CI: 0.708-1.174, p=0.475). The household wealth index emerged as the dominant, strongly protective independent predictor across all child health metrics (stunting and underweight: p<0.001; wasting: p=0.017). CONCLUSION: IPV and pediatric malnutrition represent concurrent, intersecting vulnerabilities within MP, but structural poverty is the primary independent predictor of anthropometric failure. Effective policy responses must shift beyond isolated vertical programmes, integrating gender-based violence prevention within maternal and child health platforms alongside robust household economic empowerment. CI - Copyright (c) 2026, Adhikari et al. FAU - Adhikari, Shubhankar AU - Adhikari S AD - Community Medicine, Chirayu Medical College & Hospital, Bhopal, IND. FAU - Mishra, Jaya AU - Mishra J AD - Community Medicine, Chirayu Medical College & Hospital, Bhopal, IND. FAU - Singh, Siddharth AU - Singh S AD - Community Medicine, Chirayu Medical College & Hospital, Bhopal, IND. LA - eng PT - Journal Article DEP - 20260626 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13402441 OTO - NOTNLM OT - child nutrition OT - demographic and health survey OT - domestic violence OT - india OT - intimate partner violence OT - nfhs-5 OT - population-based dataset OT - poshan abhiyaan OT - stunting OT - wasting COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/07/28 06:36 MHDA- 2026/07/28 06:37 PMCR- 2026/06/26 CRDT- 2026/07/28 04:37 PHST- 2026/06/26 00:00 [accepted] PHST- 2026/07/28 06:37 [medline] PHST- 2026/07/28 06:36 [pubmed] PHST- 2026/07/28 04:37 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - 10.7759/cureus.111586 [doi] PST - epublish SO - Cureus. 2026 Jun 26;18(6):e111586. doi: 10.7759/cureus.111586. eCollection 2026 Jun. PMID- 42516262 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260921 IS - 1939-795X (Print) IS - 1939-795X (Electronic) IS - 1939-795X (Linking) VI - 19 IP - 2 DP - 2026 TI - Qualities of Effective Nutrition Education Interventions in Athletes: A Systematic Review and Meta-Analysis. PG - 2015 LID - 10.70252/IJES2026215 [doi] LID - 2015 AB - Nutrition knowledge (NK) is consistently reported as low among athletes, potentially limiting optimal dietary intake, performance, recovery, and overall health outcomes. Sports dietitians have a responsibility to provide effective nutrition education and increase NK in athletes. Nutrition education interventions have been shown to improve NK, but practical application standards for designing and conducting nutrition interventions in athletes has yet to be established. The purpose of this meta-analysis is to measure the overall effect of nutrition education interventions on NK in athletes and identify characteristics of nutrition education interventions that effectively increase NK. Seven databases (Academic Search Premier, SPORTDiscus, MEDLINE, ERIC, Health Source: Nursing/Academic Edition, CINAHL Plus with Full Text, and Consumer Health Complete) were searched, yielding 125 studies. Fourteen studies met inclusion criteria and represented 755 athletes (ages 10-32) from various sports. SPSS was utilized to perform the meta-analysis with a random-effects model and DerSimonian-Laird procedure, and effect size (ES) estimates were expressed as Hedges' g. The overall ES of nutrition education intervention on NK was .949 (p < .001, 95% CI [.728, 1.171]), indicating a large statistically significant positive effect. Moderator analyses indicated that study design (Q = 12.577, p < .001), mode of intervention (Q = 17.479, p < .001), length (Q = 12.029, p = .002), and use of validated NK survey (Q = 19.430, p < .001) significantly influenced variation in ES. No significant differences were found for intervention type and participant age. Funnel plot asymmetry suggests potential publication bias, although Egger's test was nonsignificant (p = .897). Findings support the overall effectiveness of nutrition education interventions and provide practical insight into factors that may contribute to their success. FAU - Boyum, Lara AU - Boyum L AD - Department of Nutrition and Hospitality Management, University of Mississippi, Oxford, MS, USA. AD - Center for Health & Sports Performance, University of Mississippi, Oxford, MS, USA. FAU - Gilmore, Brooke AU - Gilmore B AD - Department of Nutrition and Hospitality Management, University of Mississippi, Oxford, MS, USA. AD - Center for Health & Sports Performance, University of Mississippi, Oxford, MS, USA. FAU - Franks, Corbit AU - Franks C AD - Center for Health & Sports Performance, University of Mississippi, Oxford, MS, USA. AD - Department of Health, Exercise Science, & Recreation Management, University of Mississippi, Oxford, MS, USA. AD - Human Movement & High-Performance Lab, University of Mississippi, Oxford, MS, USA. FAU - Kang, Minsoo AU - Kang M AD - Center for Health & Sports Performance, University of Mississippi, Oxford, MS, USA. AD - Health & Sport Analytics Laboratory, University of Mississippi, Oxford, MS, USA. LA - eng PT - Journal Article PT - Review DEP - 20260601 PL - United States TA - Int J Exerc Sci JT - International journal of exercise science JID - 101513127 PMC - PMC13405668 OTO - NOTNLM OT - Sports nutrition OT - adolescent athlete OT - performance outcomes OT - registered dietitian EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/06/01 CRDT- 2026/07/28 04:35 PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 04:35 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - ijes-19-2-15 [pii] AID - 10.70252/IJES2026215 [doi] PST - epublish SO - Int J Exerc Sci. 2026 Jun 1;19(2):2015. doi: 10.70252/IJES2026215. eCollection 2026. PMID- 42515770 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 1424-8247 (Print) IS - 1424-8247 (Electronic) IS - 1424-8247 (Linking) VI - 19 IP - 7 DP - 2026 Jul 15 TI - Advancing Pediatric Dose Scaling: Strategies, Modeling Approaches, and Clinical Applications. LID - 10.3390/ph19071090 [doi] LID - 1090 AB - Background/Objectives: Selecting appropriate doses for pediatric patients remains one of the most complex challenges in drug development because developmental changes in physiology, metabolism, organ function, and pharmacodynamics substantially influence drug exposure and response. This review summarizes current evidence-based approaches to pediatric dose selection across the developmental continuum and evaluates contemporary model-informed strategies for individualized dosing. Methods: A narrative review of the literature was conducted focusing on pediatric dose-scaling methodologies, developmental pharmacology, physiologically based pharmacokinetic (PBPK) modeling, population pharmacokinetic (PopPK) approaches, exposure-response analysis, therapeutic drug monitoring, and regulatory extrapolation frameworks. Special populations and clinical scenarios relevant to pediatric dose optimization were also evaluated. Results: Simple body weight-based scaling from adult doses inadequately accounts for developmental changes in drug disposition and response. Allometric scaling combined with maturation functions provides improved dose prediction in neonates and infants, while PBPK and PopPK modeling support mechanistic and data-driven dose optimization across pediatric age groups. Fat-free-mass (FFM)-based scaling is preferred over total body weight for many drugs in children with obesity. Additional considerations including obesity, biologics, formulation and excipient safety, pharmacogenomics, critical illness, therapeutic hypothermia, extracorporeal support, therapeutic drug monitoring, and drug-drug interactions substantially influence pediatric dosing strategies. Regulatory frameworks including ICH E11A increasingly support model-informed pediatric extrapolation and precision dosing approaches. Conclusions: Pediatric dose selection has evolved from empirical weight-based dosing toward integrated model-informed strategies incorporating developmental physiology, pharmacometrics, and regulatory science. Allometry, maturation functions, FFM-based scaling, PBPK, PopPK, and therapeutic drug monitoring provide complementary tools for rational pediatric dose optimization, although drug- and pathway-specific validation remains essential, particularly in neonates and critically ill children. FAU - Kudgus Lokken, Rachel A AU - Kudgus Lokken RA AD - Allucent, Cary, NC 27513, USA. FAU - Illamola, Silvia M AU - Illamola SM AD - Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. FAU - Job, Kathleen M AU - Job KM AUID- ORCID: 0000-0003-0255-654X AD - Division of Clinical Pharmacology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84108, USA. FAU - Al-Sallami, Hesham S AU - Al-Sallami HS AUID- ORCID: 0000-0002-0685-327X AD - College of Pharmacy, QU Health, Qatar University, Doha P.O. Box 2713, Qatar. FAU - 't Jong, Geert W AU - 't Jong GW AD - Children's Hospital Research Institute of Manitoba, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 3P4, Canada. FAU - Reith, David M AU - Reith DM AUID- ORCID: 0000-0002-2447-365X AD - Faculty of Medicine, University of Otago, Dunedin 9054, New Zealand. FAU - Birnbaum, Angela K AU - Birnbaum AK AUID- ORCID: 0000-0002-3969-4906 AD - Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. AD - Division of Clinical Pharmacology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84108, USA. AD - Center for Clinical and Cognitive Neuropharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. AD - Department of Medical Laboratory Sciences, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. FAU - Sherwin, Catherine M AU - Sherwin CM AUID- ORCID: 0000-0002-0844-3207 AD - Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. AD - Division of Clinical Pharmacology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84108, USA. AD - Internal Medicine, UWA Medical School, The University of Western Australia, Perth, WA 6009, Australia. AD - Differentia Biotech Ltd., South San Francisco, CA 94080, USA. AD - Department of Pharmacology and Toxicology, Wright State University Boonshoft School of Medicine, Dayton, OH 45435, USA. LA - eng PT - Journal Article PT - Review DEP - 20260715 PL - Switzerland TA - Pharmaceuticals (Basel) JT - Pharmaceuticals (Basel, Switzerland) JID - 101238453 PMC - PMC13415250 OTO - NOTNLM OT - PBPK modeling OT - allometric scaling OT - dose scaling OT - model-informed drug development (MIDD) OT - neonatal OT - ontogeny OT - pediatric pharmacokinetics OT - pharmacometrics OT - population pharmacokinetics COIS- R.A.K.L. is an employee of Allucent, Cary, NC, USA. C.M.S. is an employee of Differentia Biotech Ltd. but has no stocks, equity, or financial interests in the company. C.M.S. is a Guest Editor for Pharmaceuticals; however, she was not involved in the peer review process or editorial decision-making for this manuscript. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/15 CRDT- 2026/07/28 01:23 PHST- 2026/05/29 00:00 [received] PHST- 2026/07/05 00:00 [revised] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:23 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - ph19071090 [pii] AID - pharmaceuticals-19-01090 [pii] AID - 10.3390/ph19071090 [doi] PST - epublish SO - Pharmaceuticals (Basel). 2026 Jul 15;19(7):1090. doi: 10.3390/ph19071090. PMID- 42514449 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 21 TI - Estimation of Cardiometabolic Risk in Turkish Adolescents Using Different Anthropometric Techniques: Development and Temporal Validation of a Machine Learning Model. LID - 10.3390/nu18142380 [doi] LID - 2380 AB - BACKGROUND: Although obesity is a recognized cardiometabolic risk determinant, debate persists over the most appropriate anthropometric technique. This study evaluated different anthropometric techniques for predicting cardiometabolic risk in Turkish adolescents and aimed to develop and temporally validate a machine learning-based prediction model, reported in accordance with the TRIPOD statement. METHODS: Adolescents from the Turkiye Nutrition and Health Survey in 2010 (n = 1357) and 2017 (n = 561) were included. Anthropometric and biochemical parameters were assessed. BMI z-scores, waist-to-hip and waist-to-height ratios, triponderal mass index (TMI), visceral adiposity index (VAI), and lipid accumulation product (LAP) were calculated. RESULTS: In ROC analysis, VAI showed the highest discrimination (AUC = 0.747, p < 0.001), followed by LAP (AUC = 0.670). In machine learning, XGBoost achieved the highest training discrimination (ROC-AUC = 0.879), whereas logistic regression was the most stable, with minimal overfitting (DeltaAUC = 0.008). The logistic regression model was well calibrated (Brier score = 0.107; calibration slope 1.00 development, 1.03 external). External temporal validation showed comparable discrimination across models (AUC = 0.742-0.757), with logistic regression showing the greatest consistency. The model showed a high negative predictive value (NPV = 91.7%) and was therefore better suited to ruling out than ruling in cardiometabolic risk; positive findings warrant confirmatory testing (PPV = 35.4%). A simple logistic-based formula was derived. CONCLUSIONS: Machine learning approaches, together with the developed model and simplified formula, may be useful tools for estimating cardiometabolic risk in adolescents and could support a stepwise screening strategy, pending recalibration and prospective validation. FAU - Kahriman, Meryem AU - Kahriman M AUID- ORCID: 0000-0002-6908-7381 AD - Department of Nutrition and Dietetics, Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Istanbul, Turkiye. FAU - Cakir Bicer, Nihan AU - Cakir Bicer N AUID- ORCID: 0000-0002-7581-9083 AD - Department of Nutrition and Dietetics, Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Istanbul, Turkiye. AD - Department of Molecular Gastroenterology and Hepatology, Institute of Gastroenterology and Hepatology, Kocaeli University, 41001 Kocaeli, Turkiye. FAU - Bas, Murat AU - Bas M AUID- ORCID: 0000-0002-0494-301X AD - Department of Nutrition and Dietetics, Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Istanbul, Turkiye. AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Istanbul, Turkiye. LA - eng PT - Journal Article PT - Validation Study DEP - 20260721 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Turkey/epidemiology MH - Adolescent MH - Female MH - Male MH - Predictive Learning Models MH - *Machine Learning MH - *Anthropometry/methods MH - *Cardiometabolic Risk Factors MH - *Cardiovascular Diseases/epidemiology/etiology/diagnosis MH - Body Mass Index MH - Logistic Models MH - Risk Assessment/methods MH - ROC Curve MH - Risk Factors MH - Classification Algorithms PMC - PMC13415240 OTO - NOTNLM OT - body mass index OT - cardiometabolic risk OT - lipid accumulation product index OT - triponderal mass index OT - visceral adiposity index COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/21 CRDT- 2026/07/28 01:18 PHST- 2026/06/23 00:00 [received] PHST- 2026/07/16 00:00 [revised] PHST- 2026/07/17 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:18 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - nu18142380 [pii] AID - nutrients-18-02380 [pii] AID - 10.3390/nu18142380 [doi] PST - epublish SO - Nutrients. 2026 Jul 21;18(14):2380. doi: 10.3390/nu18142380. PMID- 42514408 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260831 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 16 TI - Validation of a Nutrition Screening Tool in Critically Ill Children. LID - 10.3390/nu18142340 [doi] LID - 2340 AB - Background/Objectives: Malnutrition is prevalent among patients in the pediatric intensive care unit (PICU) and has been shown to worsen in some patients during the PICU stay. In critically ill children, malnutrition is associated with longer PICU length of stay and increased mortality. Several tools have been developed and validated to screen for nutritional status in children, but none were specifically designed for critically ill children. Our study aims to fill this gap. The goal of this study was to refine and validate a novel PICU nutrition screening tool in a diverse population of critically ill children from six PICUs across the United States. Methods: Subjects underwent the nutrition screen and a Subjective Global Nutritional Assessment (SGNA). We used chi-square tests and Mann-Whitney tests to compare elements of the nutrition screen to the SGNA to identify those elements most associated with malnutrition. We used stepwise logistic regression to determine the best fitting model for a malnutrition screening tool. We proposed a scoring system using the factors identified in the best fitting model to define a positive screen. Results: We enrolled 732 subjects at six PICUs. Of these, 131 subjects (17.9%) were malnourished per the SGNA. Children with and without malnutrition did not differ with respect to age, sex, or race. The likelihood of malnutrition increased as weight-for-age percentile decreased (p < 0.001). We found that the best fitting model of a malnutrition screening tool for critically ill children included weight-for-age percentile, cancer, feeding less, parent perception of growth as poor, and being significantly underweight. We defined a positive screen that should prompt referral to a dietitian. Conclusions: We have developed a nutrition screening tool for critically ill children. FAU - Burneske, Anna AU - Burneske A AUID- ORCID: 0009-0000-9618-266X AD - Division of Critical Care, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA. FAU - Ellenbecker, Collin AU - Ellenbecker C AD - Division of Critical Care, Department of Pediatrics, University of Wisconsin, Madison, WI 53792, USA. FAU - Kuhn, Evelyn AU - Kuhn E AD - Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. FAU - Swoveland, Jacob AU - Swoveland J AUID- ORCID: 0009-0006-8074-7842 AD - Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. FAU - Oelstrom, Matt AU - Oelstrom M AD - Marshfield Clinic, Marshfield, WI 54449, USA. FAU - Hagen, Scott AU - Hagen S AD - Division of Critical Care, Department of Pediatrics, University of Wisconsin, Madison, WI 53792, USA. FAU - Mandli, Sarah AU - Mandli S AUID- ORCID: 0000-0001-8913-4328 AD - Division of Critical Care, Department of Pediatrics, University of Wisconsin, Madison, WI 53792, USA. FAU - Sears, Lynne AU - Sears L AD - Division of Critical Care, Department of Pediatrics, University of Wisconsin, Madison, WI 53792, USA. FAU - Peterson, Jennifer AU - Peterson J AD - Gundersen Health Systems Hospitals and Clinics, La Crosse, WI 54601, USA. FAU - Pringle, Charlene P AU - Pringle CP AUID- ORCID: 0000-0003-3345-7827 AD - Division of Critical Care, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA. FAU - Sheridan, Kelly AU - Sheridan K AD - Division of Critical Care, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA. FAU - Foxe, Megan AU - Foxe M AD - Division of Critical Care, Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA. FAU - Hebron, Abigail AU - Hebron A AD - Division of Critical Care, Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA. FAU - Zivick, Elizabeth AU - Zivick E AUID- ORCID: 0000-0001-9916-7211 AD - Division of Critical Care, Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA. FAU - Fabus, Nicole AU - Fabus N AD - Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. FAU - Heisler, Rebecca AU - Heisler R AD - Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. FAU - Froh, Melissa AU - Froh M AD - Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. FAU - Shad, Sadaf AU - Shad S AD - Division of Critical Care, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA. AD - Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. FAU - Mikhailov, Theresa AU - Mikhailov T AUID- ORCID: 0000-0003-1744-9739 AD - Division of Critical Care, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA. AD - Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. LA - eng PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20260716 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Critical Illness MH - Female MH - Child, Preschool MH - *Nutrition Assessment MH - Male MH - Intensive Care Units, Pediatric MH - *Nutritional Status MH - Child MH - Infant MH - *Malnutrition/diagnosis MH - Logistic Models MH - United States MH - *Mass Screening/methods MH - *Child Nutrition Disorders/diagnosis MH - Reproducibility of Results MH - Adolescent PMC - PMC13416380 OTO - NOTNLM OT - clinical nutrition OT - critically ill child OT - enteral nutrition OT - malnutrition OT - nutrition screening tool OT - nutritional support OT - pediatric nutrition COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/16 CRDT- 2026/07/28 01:18 PHST- 2026/05/04 00:00 [received] PHST- 2026/06/29 00:00 [revised] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:18 [entrez] PHST- 2026/07/16 00:00 [pmc-release] AID - nu18142340 [pii] AID - nutrients-18-02340 [pii] AID - 10.3390/nu18142340 [doi] PST - epublish SO - Nutrients. 2026 Jul 16;18(14):2340. doi: 10.3390/nu18142340. PMID- 42514367 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 14 TI - Diagnostic Utility of Simple Inflammatory Markers for Metabolic Dysfunction-Associated Steatotic Liver Disease and Metabolic Syndrome in Children with Obesity. LID - 10.3390/nu18142298 [doi] LID - 2298 AB - Background: Obesity markedly increases the risk of metabolic syndrome (MetS) and metabolic dysfunction-associated steatotic liver disease (MASLD), both of which are characterized by persistent low-grade inflammation. This study aimed to evaluate the diagnostic utility of complete blood count-derived inflammatory markers, including neutrophil-percentage-to-albumin ratio (NPAR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR), for MASLD and MetS in children with obesity. Methods: Children with obesity aged 7-18 years were prospectively enrolled and underwent anthropometric assessment, laboratory evaluation, and transient elastography with controlled attenuation parameter (CAP) measurement. Participants were classified into MASLD (CAP >/= 250 dB/m) and non-MASLD groups. Children aged >/=10 years were additionally evaluated for MetS according to the International Diabetes Federation criteria. Logistic regression analyses assessed associations between inflammatory markers and MASLD or MetS, while receiver operating characteristic (ROC) analysis evaluated their diagnostic performance. Results: Children with MASLD had significantly higher NLR and lower LMR values than those without MASLD. Higher NLR (OR = 1.946, 95% CI: 1.092-3.467, p = 0.024) and lower LMR (OR = 0.722, 95% CI: 0.539-0.966, p = 0.028) were associated with MASLD, whereas NPAR and PLR were not. After adjustment for age, sex, body mass index and C-reactive protein, both NLR and LMR remained independently associated with MASLD. ROC analysis showed moderate diagnostic performance (AUC = 0.629 for NLR and 0.616 for LMR). None of the evaluated markers were associated with MetS. Conclusions: NLR and LMR were independently associated with MASLD in children with obesity and may represent complementary screening biomarkers for pediatric MASLD. However, given the cross-sectional design and moderate diagnostic performance observed in this study, prospective multicenter studies are needed to validate these findings before clinical implementation. FAU - Zajkowska-Sierpniak, Aleksandra M AU - Zajkowska-Sierpniak AM AUID- ORCID: 0009-0008-0526-3092 AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Kwiatek-Sredzinska, Kamila A AU - Kwiatek-Sredzinska KA AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Kowalczuk-Kryston, Monika AU - Kowalczuk-Kryston M AUID- ORCID: 0000-0003-0717-9165 AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Lebensztejn, Anna AU - Lebensztejn A AD - Students' Scientific Association Affiliated with the Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Bobrus-Chociej, Anna AU - Bobrus-Chociej A AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Flisiak-Jackiewicz, Marta AU - Flisiak-Jackiewicz M AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Cudowska, Beata AU - Cudowska B AUID- ORCID: 0000-0002-8062-5865 AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Lebensztejn, Dariusz M AU - Lebensztejn DM AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. LA - eng GR - Grant No: B.SUB.26.423./Medical University of Bialystok/ PT - Journal Article DEP - 20260714 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Child MH - *Metabolic Syndrome/diagnosis/blood/etiology/complications MH - Male MH - Female MH - Biomarkers/blood MH - Adolescent MH - *Inflammation/blood MH - Prospective Studies MH - *Pediatric Obesity/complications/blood MH - ROC Curve MH - *Non-alcoholic Fatty Liver Disease/diagnosis/blood MH - *Fatty Liver/diagnosis/blood/etiology MH - Neutrophils MH - Lymphocytes PMC - PMC13414763 OTO - NOTNLM OT - children OT - inflammatory markers OT - metabolic dysfunction-associated steatotic liver disease OT - metabolic syndrome OT - obesity COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/14 CRDT- 2026/07/28 01:18 PHST- 2026/06/12 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/11 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:18 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - nu18142298 [pii] AID - nutrients-18-02298 [pii] AID - 10.3390/nu18142298 [doi] PST - epublish SO - Nutrients. 2026 Jul 14;18(14):2298. doi: 10.3390/nu18142298. PMID- 42514362 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 13 TI - The EduNutriCRC Questionnaire: A Pilot Knowledge-Attitudes-Practices Study on Nutritional Prevention of Colorectal Cancer in Romanian Adults. LID - 10.3390/nu18142293 [doi] LID - 2293 AB - BACKGROUND/OBJECTIVES: Colorectal cancer (CRC) disproportionately affects Romania, where mortality exceeds the EU average and screening uptake remains low. Diet is among the most modifiable CRC risk factors, yet no validated instrument for assessing nutritional knowledge, attitudes, and practices (KAP) related to CRC prevention exists for the Romanian population. We developed and pilot-tested the EduNutriCRC questionnaire and characterised the corresponding nutritional KAP profile of Romanian adults. METHODS: In a cross-sectional pilot study (April-May 2026), a convenience sample of 301 Romanian adults aged 18-74 years completed the 51-item self-administered questionnaire. The instrument was evaluated for internal consistency and dimensional structure (exploratory factor analysis), with non-parametric tests used for group comparisons. RESULTS: The composite knowledge score (C1-C9; maximum 9) was 6.12 +/- 2.25 with wide item-level variation. Internal consistency was acceptable, and the Attitudes subscale resolved into two factors (Motivation & Self-Efficacy and Perceived Barriers). Screening engagement was critically low (92.4% never tested; 81.7% unaware of the national programme). Although 64.1% expressed willingness to change their diet, 46.2% reported consuming processed meat at least weekly. Motivation & Self-Efficacy, but not the knowledge score, was inversely correlated with risk-food consumption (rho = -0.39, p < 0.001). CONCLUSIONS: EduNutriCRC demonstrated acceptable psychometric properties at the pilot stage. The study identified prevalent nutritional misconceptions, a marked knowledge-behaviour gap, low screening awareness, and a structural mismatch between information sources used and those trusted. Attitudes and self-efficacy, rather than factual knowledge, were the more proximal correlates of dietary behaviour, supporting the development of self-efficacy-focused, culturally adapted educational interventions for CRC prevention in Romania, with EduNutriCRC serving as a baseline and monitoring instrument. FAU - Neamtu, Andreea-Adriana AU - Neamtu AA AUID- ORCID: 0000-0002-5219-5466 AD - Department of Toxicology, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. AD - Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. AD - Department of Pathology, Clinical County Emergency Hospital of Arad, Andrenyi Karoly Str., No. 2-4, 310037 Arad, Romania. AD - Department of Pathology, "Pius Brinzeu" Clinical County Emergency Hospital Timisoara, Liviu Rebreanu Boulevard, No. 156, 300723 Timisoara, Romania. FAU - Anton, Alina AU - Anton A AUID- ORCID: 0000-0002-3818-5261 AD - Department of Toxicology, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. AD - Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. FAU - Maghiar, Laura AU - Maghiar L AUID- ORCID: 0000-0001-8901-8271 AD - Department of Psycho-Neurosciences and Rehabilitation, Faculty of Medicine and Pharmacy, University of Oradea, Universitatii Str., No. 1, 410087 Oradea, Romania. AD - Department of Dermatovenerology, Clinical County Emergency Hospital Bihor, 410169 Oradea, Romania. FAU - Iftode, Andrada AU - Iftode A AD - Department of Toxicology, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. AD - Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. FAU - Capraru, Anca-Maria AU - Capraru AM AUID- ORCID: 0009-0001-5908-0231 AD - Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. AD - Department of Pharmacy, Poiana Mare Psychiatry Hospital, Garii Str., No. 40, 207470 Poiana Mare, Romania. FAU - Dumitrescu, Cristina AU - Dumitrescu C AD - Department of Toxicology, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. AD - Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. FAU - Kis, Andreea-Mihaela AU - Kis AM AUID- ORCID: 0009-0004-4581-8487 AD - Department of Management and Communication in Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. FAU - Popovici, Ramona Amina AU - Popovici RA AUID- ORCID: 0000-0002-3852-9060 AD - Department of Management and Communication in Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. FAU - Dehelean, Cristina-Adriana AU - Dehelean CA AD - Department of Toxicology, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. AD - Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. FAU - Maghiar, Teodor-Andrei AU - Maghiar TA AD - Department of Surgery, Faculty of Medicine and Pharmacy, University of Oradea, Universitatii Str., No. 1, 410087 Oradea, Romania. AD - Department of Surgery, Pelican Hospital, Corneliu Coposu Str., No. 2, 410450 Oradea, Romania. LA - eng PT - Journal Article DEP - 20260713 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adult MH - Middle Aged MH - Romania MH - *Colorectal Neoplasms/prevention & control MH - *Health Knowledge, Attitudes, Practice MH - Female MH - Male MH - Pilot Projects MH - Aged MH - Surveys and Questionnaires MH - Cross-Sectional Studies MH - Adolescent MH - Young Adult MH - *Diet MH - Risk Factors MH - Nutritional Status MH - Feeding Behavior PMC - PMC13414599 OTO - NOTNLM OT - cancer prevention OT - colorectal cancer OT - dietary risk factors OT - health literacy OT - knowledge-attitudes-practices (KAP) OT - nutrition education OT - nutritional prevention OT - pilot validation study OT - questionnaire COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/13 CRDT- 2026/07/28 01:18 PHST- 2026/05/26 00:00 [received] PHST- 2026/06/26 00:00 [revised] PHST- 2026/07/11 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:18 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - nu18142293 [pii] AID - nutrients-18-02293 [pii] AID - 10.3390/nu18142293 [doi] PST - epublish SO - Nutrients. 2026 Jul 13;18(14):2293. doi: 10.3390/nu18142293. PMID- 42514356 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 13 TI - Understanding the Gap Between Nutritional Knowledge and Dietary Behavior Among Adolescents with Different BMI Statuses. LID - 10.3390/nu18142287 [doi] LID - 2287 AB - Background/Objectives: The aim of this study was to examine the discrepancy between nutrition-related knowledge (NRK) and nutrition-related practice (NRP) among 1440 Polish school-aged students (10-18 years), according to BMI status, and to identify factors associated with this discrepancy. Methods: This cross-sectional study was conducted via the CAWI method using an author-developed, non-validated questionnaire. Questions assessing NRK and NRP were thematically aligned and referred to the recommendations of the Polish Healthy Eating and Lifestyle Pyramid for Children and Adolescents (aged 4-18 years). Results: Students with excess weight scored significantly lower in nutritional knowledge (NRK: 46%) and practices (NRP: 30%) than those with underweight or normal weight (NRK: 52-53%, NRP: 33-34%). Higher NRK was associated with older age, female sex, larger urban residence (for students with overweight and obesity), and higher maternal/legal guardian education level (for students with normal/underweight body weight). Better NRP was associated with higher NRK and higher physical activity, while rural or small-town living was positively associated with healthier dietary practices and maintenance of normal BMI. Conclusions: The present study confirms that nutritional knowledge is a necessary but insufficient condition for shaping appropriate dietary behaviors among adolescents with different BMI statuses; lifestyle factors, practical food-related skills-including self-assessment of knowledge and adherence to dietary recommendations-and the broader environmental context plays a crucial role. These findings highlight the need for targeted nutrition education programs that expand not only knowledge but also practical skills among students. FAU - Wawrzyniak, Agata AU - Wawrzyniak A AUID- ORCID: 0000-0002-8452-0526 AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (SGGW-WULS), 02-787 Warsaw, Poland. FAU - Traczyk, Iwona AU - Traczyk I AUID- ORCID: 0000-0001-7413-1212 AD - The Department of Environmental Hazard Prevention, Allergology and Immunology, Faculty of Health Sciences, Medical University of Warsaw, 02-007 Warsaw, Poland. LA - eng PT - Journal Article DEP - 20260713 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - Female MH - *Health Knowledge, Attitudes, Practice MH - Male MH - *Body Mass Index MH - Cross-Sectional Studies MH - Child MH - *Feeding Behavior/psychology MH - Poland MH - *Diet, Healthy MH - Surveys and Questionnaires MH - *Adolescent Behavior MH - Nutritional Status MH - Overweight MH - Life Style PMC - PMC13415248 OTO - NOTNLM OT - adolescents OT - body mass index (BMI) OT - food literacy OT - nutrition literacy OT - nutrition-related knowledge (NRK) OT - nutrition-related practice (NRP) OT - physical activity OT - socio-demographic factors COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/13 CRDT- 2026/07/28 01:18 PHST- 2026/06/12 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:18 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - nu18142287 [pii] AID - nutrients-18-02287 [pii] AID - 10.3390/nu18142287 [doi] PST - epublish SO - Nutrients. 2026 Jul 13;18(14):2287. doi: 10.3390/nu18142287. PMID- 42514328 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 10 TI - Sub-Optimal Nutritional Knowledge and Dietary Intake in Gaelic Team Sport Athletes: Limited Associations Between Knowledge and Dietary Adequacy. LID - 10.3390/nu18142259 [doi] LID - 2259 AB - Background/Objectives: To assess the nutritional knowledge and dietary intake of Gaelic team sport athletes and investigate any association between nutrition knowledge and dietary intake. Methods: Male/female athletes competing in Gaelic football, hurling and camogie, aged 18-40 years and training/competing at least twice weekly, were recruited. Nutrition knowledge was assessed using the validated Nutrition for Sport Knowledge Questionnaire (NSKQ). Dietary intake was assessed using a 4-day semi-quantitative food diary. Results: In total, 354 players (male n = 215, female n = 139; elite n = 133, sub-elite n = 221) completed the NSKQ; 53.1% had "poor" knowledge (score 0.70), although several scales showed lower reliability estimates. Results: Adolescents diagnosed with eating disorders showed significantly higher levels of problematic eating behaviours (rg = 0.94), exercise fixation (rg = 0.71), exercise commitment (rg = 0.33), withdrawal symptoms (rg = 0.52), exercise for weight control (rg = 0.83), and insight into problems (rg = 0.77) than athletes. In contrast, athletes reported higher levels of exercise for social (rg = 0.74) and health-related reasons (rg = 0.40). Effect sizes ranged from moderate to very large. These findings indicate marked differences in the psychological motives and compulsive characteristics of exercise between adolescents with eating disorders and athletes. Conclusions: This pilot study suggests that adolescents with eating disorders differ from athletes primarily in the psychological characteristics and motives underlying exercise rather than in exercise volume alone. These findings may help inform the assessment of problematic exercise in clinical practice, although they require confirmation in larger, adequately controlled studies. FAU - Jaroch-Lidzbarska, Magdalena AU - Jaroch-Lidzbarska M AUID- ORCID: 0000-0002-5355-8716 AD - Department of Physical Culture, Gdansk University of Physical Education and Sport, Kazimierza Gorskiego 1, 80-336 Gdansk, Poland. FAU - Hryniewicz, Konrad AU - Hryniewicz K AD - Department of Marketing and Quantitative Methods, Faculty of Management and Quality Science, Gdynia Maritime University, Morska 81/87, 81-225 Gdynia, Poland. FAU - Sawicki, Piotr AU - Sawicki P AD - Department of Physical Culture, Gdansk University of Physical Education and Sport, Kazimierza Gorskiego 1, 80-336 Gdansk, Poland. FAU - Wilczynska, Dominika AU - Wilczynska D AD - Faculty of Social and Humanities, WSB Merito University, Grunwaldzka 238A, 80-266 Gdansk, Poland. LA - eng PT - Journal Article DEP - 20260712 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13412378 OTO - NOTNLM OT - adolescents OT - athletes OT - eating disorders OT - obligatory exercise OT - psychiatric patients COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/12 CRDT- 2026/07/28 01:14 PHST- 2026/05/24 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:14 [entrez] PHST- 2026/07/12 00:00 [pmc-release] AID - jcm15145455 [pii] AID - jcm-15-05455 [pii] AID - 10.3390/jcm15145455 [doi] PST - epublish SO - J Clin Med. 2026 Jul 12;15(14):5455. doi: 10.3390/jcm15145455. PMID- 42512745 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 14 DP - 2026 Jul 22 TI - Validation of the Revised Version of the Social Cognitive Theory-Based Scale for Factors Influencing Eating Behavior in Adolescents. LID - 10.3390/healthcare14142229 [doi] LID - 2229 AB - Background/Objectives: Social Cognitive Theory (SCT) constructs are associated with adolescents' eating habits. Validated surveys are needed to assess these constructs (in different populations and languages), considering both personal and socio-environmental factors, including peer influence. Therefore, the objective of this study was to validate the SCT-based Scale for Factors Influencing Eating Behavior in Adolescents (SCT-FIEBA), in Spanish. Methods: The scale was administered to 705 high school students from two schools in the Guadalajara Metropolitan Area, Mexico, with randomized and stratified selection. Two weeks later, 43 participants completed the retest. Construct validity was assessed using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA); internal consistency was assessed using Cronbach's alpha and McDonald's omega; and temporal stability was assessed using the Intraclass Correlation Coefficient (ICC), with 95% confidence intervals (CIs). Additionally, factor patterns influencing eating behavior were identified using hierarchical cluster analysis and discriminant analysis. Results: EFA (n = 353) showed an adequate structure with seven or eight factors (with 34 items). However, CFA (n = 352) showed a better fit with eight factors and 33 items (RMSEA = 0.073, SRMR = 0.083, CFI = 0.91, TLI = 0.90) than the other models. The scale's internal consistency was excellent (Cronbach's alpha = 0.92, CI 0.92-0.93; McDonald's omega = 0.93, CI 0.92-0.93), with all sections scoring from moderate to excellent. The reproducibility indices were good for the whole scale (ICC = 0.70, CI 0.50-0.82) and four sections; the other four presented moderate values. It is recommended to verify reproducibility in a larger sample. Hierarchical cluster analysis yielded better results with four patterns influencing eating behavior based on SCT, and the discriminant analysis results were satisfactory (Wilks' lambda = 0.108; 87% of cases correctly classified). Conclusions: The SCT-FIEBA demonstrated validity and reliability for assessing SCT constructs applied to eating behavior among high school adolescents in a Mexican population, as well as for identifying four distinct psychosocial patterns that influence eating behavior. FAU - Flores-Vazquez, Ana Silvia AU - Flores-Vazquez AS AUID- ORCID: 0000-0002-2268-9959 AD - Departamento de Alimentacion y Nutricion, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Independencia, Guadalajara 44340, Jalisco, Mexico. FAU - Rodriguez-Rocha, Norma Patricia AU - Rodriguez-Rocha NP AUID- ORCID: 0000-0001-5800-3130 AD - Departamento de Alimentacion y Nutricion, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Independencia, Guadalajara 44340, Jalisco, Mexico. AD - Instituto Regional de Investigacion en Salud Publica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Independencia, Guadalajara 44340, Jalisco, Mexico. FAU - Franco-Paredes, Karina AU - Franco-Paredes K AUID- ORCID: 0000-0002-5899-3071 AD - Departamento de Promocion, Preservacion y Desarrollo de la Salud, Centro Universitario del Sur, Universidad de Guadalajara, Avenida Enrique Arreola Silva 883, Centro, Ciudad Guzman 49000, Jalisco, Mexico. FAU - Macedo-Ojeda, Gabriela AU - Macedo-Ojeda G AUID- ORCID: 0000-0002-3815-2160 AD - Departamento de Alimentacion y Nutricion, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Independencia, Guadalajara 44340, Jalisco, Mexico. AD - Instituto de Investigacion en Ciencias Biomedicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Independencia, Guadalajara 44340, Jalisco, Mexico. LA - eng GR - 661992/National Council for Humanities, Sciences, and Technologies (CONAHCYT)/ PT - Journal Article DEP - 20260722 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13411829 OTO - NOTNLM OT - adolescents OT - nutrition OT - reliability OT - scale OT - social cognitive theory OT - validity COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/22 CRDT- 2026/07/28 01:12 PHST- 2026/05/14 00:00 [received] PHST- 2026/07/16 00:00 [revised] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:12 [entrez] PHST- 2026/07/22 00:00 [pmc-release] AID - healthcare14142229 [pii] AID - healthcare-14-02229 [pii] AID - 10.3390/healthcare14142229 [doi] PST - epublish SO - Healthcare (Basel). 2026 Jul 22;14(14):2229. doi: 10.3390/healthcare14142229. PMID- 42512699 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 14 DP - 2026 Jul 20 TI - Exploring the Association Between Psychological Inflexibility, Experiential Avoidance and Sleep-Related Problems Among Adolescents: The EHDLA Study. LID - 10.3390/healthcare14142183 [doi] LID - 2183 AB - Background: Adolescence is a sensitive period during which sleep undergoes substantial change, increasing vulnerability to sleep disturbances and their health consequences. Psychological inflexibility (PI) and experiential avoidance (EA), operationalized through the Acceptance and Action Questionnaire-II (AAQ-II), have been associated with poorer sleep among adults; however, evidence in adolescents remains scarce. This study examined the association between PI, EA, and sleep-related problems in a representative sample of Spanish adolescents. Methods: A cross-sectional analysis was conducted using data from 623 adolescents (aged 12-17 years; 56.7% girls) from the Eating Healthy and Daily Life Activities (EHDLA) study, conducted in the Valle de Ricote (Murcia, Spain) during 2021-2022. PI and EA were assessed with the Spanish-validated AAQ-II; sleep-related problems were screened using the BEARS (B = Bedtime problems, E = Excessive daytime sleepiness, A = Awakenings during the night, R = Regularity and duration of sleep, S = Snoring) questionnaire across five domains. Generalized linear models were adjusted for sex, age, socioeconomic status, physical activity, sedentary behavior, body mass index (BMI) z-score, energy intake, and sleep duration. Results: Higher AAQ-II scores were significantly associated with increased probabilities of bedtime problems (+0.9% per point; 95% confidence interval [CI]: 0.6-1.1%), excessive daytime sleepiness (+1.0%; 95% CI: 0.7-1.2%), nocturnal awakenings (+0.7%; 95% CI: 0.5-1.0%), and problems with sleep regularity and duration (+0.8%; 95% CI: 0.5-1.1%). Each additional AAQ-II point increased the probability of reporting any sleep-related problem by 1.2% (95% CI: 0.9-1.5%; p < 0.001). Corresponding adjusted odds ratios ranged from 1.04 to 1.06 per point. No significant association was found for snoring. Conclusions: In this cross-sectional study, psychological inflexibility and experiential avoidance were positively associated with several sleep-related problems among adolescents. Longitudinal and intervention studies are warranted before causal or clinical recommendations can be made. FAU - Zalamea-Delgado, Maria Paula AU - Zalamea-Delgado MP AUID- ORCID: 0009-0004-2607-2907 AD - School of Medicine, Universidad Espiritu Santo, Samborondon, Guayaquil 0901952, Ecuador. FAU - Jimenez-Lopez, Estela AU - Jimenez-Lopez E AUID- ORCID: 0000-0001-8553-7701 AD - Health and Social Research Center, Universidad de Castilla-La Mancha, 16002 Cuenca, Spain. AD - Centro de Investigacion Biomedica en Red de Salud Mental, Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Mesas, Arthur Eumann AU - Mesas AE AUID- ORCID: 0000-0002-0088-8607 AD - Health and Social Research Center, Universidad de Castilla-La Mancha, 16002 Cuenca, Spain. FAU - Yanez-Sepulveda, Rodrigo AU - Yanez-Sepulveda R AUID- ORCID: 0000-0002-9311-6576 AD - Faculty Education and Social Sciences, Universidad Andres Bello, Vina del Mar 2520000, Chile. FAU - Gutierrez-Espinoza, Hector AU - Gutierrez-Espinoza H AUID- ORCID: 0000-0002-4650-3426 AD - Faculty of Education, Universidad Autonoma de Chile, Santiago 7500138, Chile. FAU - Olivares-Arancibia, Jorge AU - Olivares-Arancibia J AUID- ORCID: 0000-0002-7186-3941 AD - AFySE Group, Research in Physical Activity and School Health, School of Physical Education, Faculty of Education, Universidad de las Americas, Santiago 8320000, Chile. FAU - Ezzatvar, Yasmin AU - Ezzatvar Y AUID- ORCID: 0000-0002-9691-5998 AD - Lifestyle Factors with Impact on Ageing and Overall Health (LAH) Research Group, Department of Nursing, University of Valencia, 46010 Valencia, Spain. AD - Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno 5290000, Chile. FAU - Stubbs, Brendon AU - Stubbs B AUID- ORCID: 0000-0001-7387-3791 AD - Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London WC2R 2LS, UK. AD - Center for Sport Science and University Sports, University of Vienna, 1010 Wien, Austria. FAU - Smith, Lee AU - Smith L AUID- ORCID: 0000-0002-5340-9833 AD - Centre for Health Performance and Wellbeing, Anglia Ruskin University, Cambridge CB1 1PT, UK. AD - Department of Public Health, Faculty of Medicine, Biruni University, Istanbul 34015, Turkey. FAU - Ridgell, Lucille AU - Ridgell L AUID- ORCID: 0009-0001-5956-5925 AD - Carver University, Orlando, FL 32804, USA. FAU - Mino, Camila AU - Mino C AUID- ORCID: 0000-0002-9444-8564 AD - Universidad Internacional para el Desarrollo (UNINDE), Extremadura, 06080 Badajoz, Spain. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AUID- ORCID: 0000-0002-7412-7624 AD - School of Medicine, Universidad Espiritu Santo, Samborondon, Guayaquil 0901952, Ecuador. AD - Department of Sport Sciences, Faculty of Sport and Health Sciences, Fit Generation Research Institute, AD500 Andorra la Vella, Andorra. LA - eng PT - Journal Article DEP - 20260720 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13410315 OTO - NOTNLM OT - adolescent OT - avoidance behaviors OT - cross-sectional studies OT - experiential avoidance OT - psychological inflexibility OT - psychological resiliency OT - sleep disturbances COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/20 CRDT- 2026/07/28 01:12 PHST- 2026/05/29 00:00 [received] PHST- 2026/07/02 00:00 [revised] PHST- 2026/07/15 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:12 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - healthcare14142183 [pii] AID - healthcare-14-02183 [pii] AID - 10.3390/healthcare14142183 [doi] PST - epublish SO - Healthcare (Basel). 2026 Jul 20;14(14):2183. doi: 10.3390/healthcare14142183. PMID- 42512211 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20261014 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 23 IP - 7 DP - 2026 Jul 15 TI - Strategies to Promote the Integration of Fermented Foods in the Daily Diet to Improve Children's Health in Capricorn District, South Africa: A Mixed Method Study Protocol. LID - 10.3390/ijerph23070907 [doi] LID - 907 AB - Child health remains a critical global public health concern, with malnutrition, diarrhea and pneumonia consistently driving high morbidity and mortality rates among children under the age of five. The World Health Organization (WHO) estimates that malnutrition accounts for approximately 3.1 million child deaths annually. In South Africa, persistent challenges such as stunting, micronutrient deficiencies, and food insecurity remain prevalent, particularly in rural communities, despite the existing interventions. Fermented foods present a culturally acceptable, affordable, and sustainable strategy to address malnutrition and improve gut health, potentially reducing stunting and diarrheal diseases. This article presents a protocol for a future four-phase mixed-method study that will be conducted to develop and validate strategies to promote the integration of fermented foods into children's daily diets. The researchers will employ an exploratory sequential mixed methods design in three phases for the purpose of the envisaged study: bibliometric analysis, qualitative inquiry through in-depth interviews with caregivers and nurses, and a quantitative survey developed from qualitative findings. By combining qualitative and quantitative data, the study seeks to generate evidence-based, context-specific strategies for policy and programmatic integration. The anticipated outcome is a framework to support the inclusion of fermented foods in child nutrition programs to ensure the improved child health and progress toward the United Nations Sustainable Development Goals (UN SDGs). FAU - Malema, Masilo Isaac AU - Malema MI AUID- ORCID: 0009-0002-3138-656X AD - Department of Public Health, Sefako Makgatho Health Sciences University, 1 Molotlegi Street, Ga-Rankuwa, Pretoria 0208, South Africa. AD - Quality Management Directorate, Walter Sisulu University, Komani Campus, No. 280 Shepstone Road, East London 5200, South Africa. FAU - Matlala, Sogo France AU - Matlala SF AUID- ORCID: 0000-0002-2291-6779 AD - Department of Public Health, Sefako Makgatho Health Sciences University, 1 Molotlegi Street, Ga-Rankuwa, Pretoria 0208, South Africa. FAU - Chelule, Paul Kiprono AU - Chelule PK AUID- ORCID: 0000-0002-3477-3242 AD - Department of Public Health, Sefako Makgatho Health Sciences University, 1 Molotlegi Street, Ga-Rankuwa, Pretoria 0208, South Africa. LA - eng PT - Journal Article DEP - 20260715 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - South Africa MH - *Fermented Foods MH - Child, Preschool MH - *Child Health MH - *Diet MH - Infant MH - Research Design PMC - PMC13411124 OTO - NOTNLM OT - child nutrition OT - fermented foods OT - gut health OT - mixed methods research OT - strategy development OT - traditional diets COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/15 CRDT- 2026/07/28 01:11 PHST- 2026/03/11 00:00 [received] PHST- 2026/07/02 00:00 [revised] PHST- 2026/07/04 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:11 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - ijerph23070907 [pii] AID - ijerph-23-00907 [pii] AID - 10.3390/ijerph23070907 [doi] PST - epublish SO - Int J Environ Res Public Health. 2026 Jul 15;23(7):907. doi: 10.3390/ijerph23070907. PMID- 42510283 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 7 DP - 2026 Jul 10 TI - Effects of a Cognitively Enriched Playful Physical Activity Program on Executive Functions and School Readiness in Preschool Children. LID - 10.3390/bs16071162 [doi] LID - 1162 AB - Executive functions (EFs) are foundational for early learning and school readiness. Interventions that couple motor engagement with explicit cognitive demands may offer an efficient approach to support EFs during preschool years. This exploratory randomized controlled trial examined the preliminary effects of an 8-week Playful Physical Activities (PPA) program on EF and school readiness. Preschool children were randomized to (i) PPA, a structured program integrating executive challenges (response inhibition, working memory, and planning) into movement games, or (ii) an active control receiving the regular physical education curriculum (3 sessions/week, 60 min/session, 8 weeks). Outcomes were assessed before and after the intervention and included Go/No-Go error rate, BVMT-R immediate and delayed recall, RCFT copy score, and school readiness domains (mathematical, linguistic, and social competence). Group x Time effects were tested using mixed ANOVA and summarized with partial eta squared (eta(2)p). Between-group post-test differences were quantified using Hedges' g. PPA was associated with greater pre-to-post improvements relative to control in attentional control/inhibition (Go/No-Go errors: eta(2)p = 0.134; g = -1.78) and visuospatial organization/planning (RCFT copy: eta(2)p = 0.307; g = 1.36). Visuospatial memory outcomes showed very large interaction effects (BVMT-R immediate eta(2)p = 0.937, g = 5.14; delayed eta(2)p = 0.854, g = 4.10), but these values are exploratory and should not be emphasized as the primary evidence for cognitive improvement because the BVMT-R was used as a non-normed raw-score index outside its validated age range in this preschool sample. School readiness indicators showed favorable changes across mathematical, linguistic, and social competence (eta(2)p = 0.514, 0.385, and 0.337; g = 1.95, 2.05, and 1.31, respectively). Overall, these preliminary findings suggest that cognitively enriched movement may support EF-related performance and school-readiness indicators, but they should not be interpreted as definitive proof of efficacy. Larger prospectively registered trials with balanced groups, age-appropriate outcome measures, and stronger fidelity documentation are needed before firm recommendations can be made. FAU - Chikha, Anis Ben AU - Chikha AB AD - The Higher Institute of Sport and Physical Education (Ksar Said), University of Manouba, Manouba 2010, Tunisia. AD - Physical Activity, Sport and Health, Research Unit (UR18JS01), National Observatory of Sport, Tunis 1003, Tunisia. FAU - Eken, Ozgur AU - Eken O AUID- ORCID: 0000-0002-5488-3158 AD - Department of Physical Education and Sport Teaching, Faculty of Sports Sciences, Inonu University, Malatya 44280, Turkiye. FAU - Arslanoglu, Birgul AU - Arslanoglu B AD - Department of Humanities and Social Sciences, Faculty of Sciences and Letters, Istanbul Technical University, Istanbul 34469, Turkiye. FAU - Lousaif, Rahma AU - Lousaif R AD - The Higher Institute of Sport and Physical Education (Ksar Said), University of Manouba, Manouba 2010, Tunisia. AD - Research Laboratory (LR23JS01) "Sport Performance, Health and Society", Higher Institute of Sport and Physical Education of Ksar-Said, Manouba University, Tunis 2010, Tunisia. FAU - Goumni, Chiraz AU - Goumni C AD - The Higher Institute of Sport and Physical Education (Ksar Said), University of Manouba, Manouba 2010, Tunisia. AD - Research Laboratory (LR23JS01) "Sport Performance, Health and Society", Higher Institute of Sport and Physical Education of Ksar-Said, Manouba University, Tunis 2010, Tunisia. FAU - Bouallegui, Nejha AU - Bouallegui N AD - The Higher Institute of Sport and Physical Education (Ksar Said), University of Manouba, Manouba 2010, Tunisia. AD - Research Laboratory (LR23JS01) "Sport Performance, Health and Society", Higher Institute of Sport and Physical Education of Ksar-Said, Manouba University, Tunis 2010, Tunisia. FAU - Calisir, Melih AU - Calisir M AUID- ORCID: 0000-0002-2133-2843 AD - Department of Physical Education and Sport Teaching, Faculty of Sports Sciences, Bitlis Eren University, Bitlis 13000, Turkiye. FAU - Souissi, Nizar AU - Souissi N AD - The Higher Institute of Sport and Physical Education (Ksar Said), University of Manouba, Manouba 2010, Tunisia. AD - Physical Activity, Sport and Health, Research Unit (UR18JS01), National Observatory of Sport, Tunis 1003, Tunisia. FAU - Aldhahi, Monira I AU - Aldhahi MI AUID- ORCID: 0000-0002-5255-4860 AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. LA - eng GR - PNURSP2026R286/Princess Nourah bint Abdulrahman University/ PT - Journal Article DEP - 20260710 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13405789 OTO - NOTNLM OT - attention and inhibition OT - cognitively enriched movement OT - executive functions OT - preschool education OT - school readiness OT - visuospatial learning COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/10 CRDT- 2026/07/28 01:02 PHST- 2026/04/30 00:00 [received] PHST- 2026/06/30 00:00 [revised] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:02 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - bs16071162 [pii] AID - behavsci-16-01162 [pii] AID - 10.3390/bs16071162 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Jul 10;16(7):1162. doi: 10.3390/bs16071162. PMID- 42510090 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2075-4418 (Print) IS - 2075-4418 (Electronic) IS - 2075-4418 (Linking) VI - 16 IP - 14 DP - 2026 Jul 16 TI - Interpretable Machine Learning for Predicting Suboptimal 12-Month Growth Response to Recombinant Human Growth Hormone in Children with Idiopathic Short Stature: A Dual-Center External Validation Study. LID - 10.3390/diagnostics16142227 [doi] LID - 2227 AB - Background/Objectives: Individual responses to recombinant human growth hormone (rhGH) therapy in children with idiopathic short stature (ISS) vary substantially, limiting pretreatment decision-making. This study aimed to develop and externally validate an interpretable machine learning model for predicting suboptimal 12-month growth response to rhGH therapy. Methods: In this retrospective dual-center study, 901 children from Center 1 were used for model development and internal testing, and 51 children from Center 2 formed an independent external validation cohort. Routinely collected baseline demographic, laboratory, hormonal, radiographic, and family-history variables were used to develop multiple machine learning models. A soft-voting ensemble classifier was constructed and interpreted using SHapley Additive exPlanations (SHAP). The primary outcome was suboptimal growth response, defined as failure to achieve a height gain of at least 0.5 standard deviation score after 12 months of treatment. Results: The optimized ensemble model showed strong discrimination in the internal test set, with an area under the receiver operating characteristic curve of 0.927, and maintained robust performance in the external validation cohort, with an AUC of 0.897. SHAP analysis identified luteinizing hormone, body mass index, TW3 RUS bone age, and insulin-like growth factor 1 as the leading contributors to predicted suboptimal-response risk. Conclusions: An interpretable ensemble machine learning model based on routinely available pretreatment data can predict suboptimal short-term rhGH response in children with ISS and may support individualized risk stratification in pediatric endocrine practice. Clinical trial registration was not required because this was a retrospective analysis. FAU - Yang, Chuanyu AU - Yang C AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Shao, Yifeng AU - Shao Y AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. AD - Department of General Surgery, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Jiang, Chengyang AU - Jiang C AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. AD - Department of General Surgery, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Zhang, Runmin AU - Zhang R AD - China United Network Communications Group, Beijing Branch, Beijing 100009, China. FAU - Wang, Jian AU - Wang J AD - Department of Pediatrics, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing 102218, China. FAU - Chen, Xinlin AU - Chen X AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Zeng, Yuyuan AU - Zeng Y AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - An, Qi AU - An Q AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Peng, Nan AU - Peng N AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Wang, Xi AU - Wang X AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Zhou, Bo AU - Zhou B AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Wang, Jianhong AU - Wang J AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Wang, Lin AU - Wang L AUID- ORCID: 0000-0001-5536-781X AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. LA - eng GR - 2024-1-1131/the Special Research Project of Capital Health Development/ GR - AL-02-19/High-level Public Health Talents Training Plan/ GR - XZYC-2025-07/New Quality Foundation of Capital Institute of Pediatrics/ PT - Journal Article DEP - 20260716 PL - Switzerland TA - Diagnostics (Basel) JT - Diagnostics (Basel, Switzerland) JID - 101658402 PMC - PMC13408863 OTO - NOTNLM OT - clinical prediction model OT - idiopathic short stature OT - interpretability OT - machine learning OT - recombinant human growth hormone COIS- Author Runmin Zhang was employed by China United Network Communications Group, Beijing Branch. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/16 CRDT- 2026/07/28 01:01 PHST- 2026/06/10 00:00 [received] PHST- 2026/07/10 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/07/16 00:00 [pmc-release] AID - diagnostics16142227 [pii] AID - diagnostics-16-02227 [pii] AID - 10.3390/diagnostics16142227 [doi] PST - epublish SO - Diagnostics (Basel). 2026 Jul 16;16(14):2227. doi: 10.3390/diagnostics16142227. PMID- 42509980 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 7 DP - 2026 Jul 20 TI - Correlation Between Ambulatory Blood Pressure Monitoring and Target Organ Damage in Children. LID - 10.3390/children13070955 [doi] LID - 955 AB - BACKGROUND: Ambulatory blood pressure monitoring (ABPM) offers a comprehensive assessment of mean blood pressure (BP), circadian patterns, and out-of-office hypertension phenotypes. We evaluated the association of ABPM parameters with left ventricular hypertrophy (LVH) and hypertensive retinopathy (HRP) in children with hypertension. METHODS: This retrospective analysis included 269 children who underwent ABPM at a tertiary care facility. Multivariable logistic regression was used to evaluate associations between BP Z scores and target organ damage (TOD), adjusting for age, sex, and body mass index standard deviation score. Machine learning techniques (logistic regression, random forest, and multilayer perceptron) were also evaluated using 10-fold cross-validation across exploratory combinations of the 90th or 95th percentiles and BP-load thresholds of 25% or 50%. RESULTS: LVH was detected in 45/247 patients (18%) and HRP was observed in 22/240 patients (9%). The 24 h systolic BP Z score was independently associated with LVH (adjusted OR 1.44; 95% CI 1.16-1.80; p = 0.001). Cohort-derived systolic Z-score thresholds for LVH were 1.31 for 24 h systolic BP and 1.47 for nighttime systolic BP, corresponding to approximately the 90.6th and 93rd percentiles, respectively. No variable evaluated was independently associated with retinopathy. Logistic regression using the 90th percentile/25% load dataset showed the highest performance among the evaluated classifiers, but discrimination was limited (ROC area 0.603; MCC 0.041). CONCLUSIONS: Higher ambulatory systolic BP was independently associated with LVH but not with clinically detected hypertensive retinopathy. ABPM values at or above the 90th percentile and a systolic load of >/=25% may help identify children at increased risk of TOD, although these thresholds remain exploratory and require prospective external validation. FAU - Ozturk, Musa AU - Ozturk M AUID- ORCID: 0000-0003-4316-2002 AD - Department of Pediatrics, Ankara University Faculty of Medicine, Ankara 06100, Turkiye. FAU - Bakirarar, Batuhan AU - Bakirarar B AUID- ORCID: 0000-0002-5662-8193 AD - Department of Biostatistics, Ankara University Faculty of Medicine, Ankara 06100, Turkiye. FAU - Ozcakar, Zeynep Birsin AU - Ozcakar ZB AUID- ORCID: 0000-0002-6376-9189 AD - Division of Pediatric Nephrology, Ankara University Faculty of Medicine, Ankara 06100, Turkiye. FAU - Cakar, Nilgun AU - Cakar N AD - Division of Pediatric Nephrology, Ankara University Faculty of Medicine, Ankara 06100, Turkiye. FAU - Doganay, Beyza AU - Doganay B AD - Department of Biostatistics, Ankara University Faculty of Medicine, Ankara 06100, Turkiye. FAU - Tutar, Ercan AU - Tutar E AD - Division of Pediatric Cardiology, Ankara University Faculty of Medicine, Ankara 06100, Turkiye. FAU - Yalcinkaya, Fatos AU - Yalcinkaya F AD - Division of Pediatric Nephrology, Ankara University Faculty of Medicine, Ankara 06100, Turkiye. LA - eng PT - Journal Article DEP - 20260720 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13406871 OTO - NOTNLM OT - ambulatory blood pressure monitoring OT - childhood hypertension OT - left ventricular hypertrophy OT - machine learning OT - target organ damage COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/20 CRDT- 2026/07/28 01:01 PHST- 2026/06/18 00:00 [received] PHST- 2026/07/15 00:00 [revised] PHST- 2026/07/16 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - children13070955 [pii] AID - children-13-00955 [pii] AID - 10.3390/children13070955 [doi] PST - epublish SO - Children (Basel). 2026 Jul 20;13(7):955. doi: 10.3390/children13070955. PMID- 42509955 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 7 DP - 2026 Jul 15 TI - Criterion and Convergent Validity of Youth Physical Activity and Sedentary Behavior Questionnaires in School Settings: A Systematic Review of Current Evidence and Future Perspectives. LID - 10.3390/children13070931 [doi] LID - 931 AB - BACKGROUND/OBJECTIVES: Physical activity and sedentary behavior are key indicators of youth health, and questionnaires offer a cost-effective method for data collection. This systematic review synthesized evidence on the criterion and convergent validity of self-report questionnaires measuring physical activity and sedentary behavior in children and adolescents aged 5-18 years in school settings. METHODS: Searches were conducted in SPORTDiscus, Medline, Scopus, ERIC, Academic Search Complete, Education Source, and the Cochrane Library with no date limits. Included studies compared questionnaire results with established measures and were assessed using the consensus-based standards for the selection of health measurement instruments (COSMIN) checklist. RESULTS: Twenty-two studies covering 16 questionnaires were included; additional outcomes included test-retest reliability, content and construct validity, and psychometric evaluation. Validity correlations ranged from very weak to strong (r = 0.11-0.80; rho = 0.20-0.87), with Bland-Altman agreement (rho = 0.56-0.70) and mean absolute percentage error up to 199.6%. CONCLUSIONS: Eight questionnaires showed acceptable validity and reliability, though research is needed to strengthen evidence on measurement accuracy. FAU - Gagnon, Megane AU - Gagnon M AD - Department of Human Kinetics, Universite du Quebec a Trois-Rivieres, 3351 des Forges Blvd. P.O. Box 500, Trois-Rivieres, QC G8Z 4M3, Canada. FAU - Bouqartacha, Salma AU - Bouqartacha S AUID- ORCID: 0009-0000-6749-3047 AD - Department of Anatomy, Universite du Quebec a Trois-Rivieres, 3351 des Forges Blvd. P.O. Box 500, Trois-Rivieres, QC G8Z 4M3, Canada. FAU - Bedard, Eloane AU - Bedard E AD - Department of Human Kinetics, Universite du Quebec a Trois-Rivieres, 3351 des Forges Blvd. P.O. Box 500, Trois-Rivieres, QC G8Z 4M3, Canada. FAU - Delattre, Livia AU - Delattre L AD - Department of Human Kinetics, Universite du Quebec a Trois-Rivieres, 3351 des Forges Blvd. P.O. Box 500, Trois-Rivieres, QC G8Z 4M3, Canada. FAU - Descarreaux, Martin AU - Descarreaux M AD - Department of Human Kinetics, Universite du Quebec a Trois-Rivieres, 3351 des Forges Blvd. P.O. Box 500, Trois-Rivieres, QC G8Z 4M3, Canada. FAU - Guimaraes, Roseane de Fatima AU - Guimaraes RF AUID- ORCID: 0000-0001-8151-7914 AD - Department of Human Kinetics, Universite du Quebec a Trois-Rivieres, 3351 des Forges Blvd. P.O. Box 500, Trois-Rivieres, QC G8Z 4M3, Canada. LA - eng GR - CMDO/FRQS 35330/Research Network on cardiometabolic health, diabetes and obesity/ GR - UQTR institutional Research Chair on lifestyle habits and health in youth/University of Quebec at Trois-Rivieres/ PT - Journal Article PT - Review DEP - 20260715 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13406170 OTO - NOTNLM OT - children and adolescents OT - physical activity OT - questionnaire validity OT - sedentary behavior OT - systematic review COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/15 CRDT- 2026/07/28 01:01 PHST- 2026/06/12 00:00 [received] PHST- 2026/07/07 00:00 [revised] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - children13070931 [pii] AID - children-13-00931 [pii] AID - 10.3390/children13070931 [doi] PST - epublish SO - Children (Basel). 2026 Jul 15;13(7):931. doi: 10.3390/children13070931. PMID- 42509931 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 7 DP - 2026 Jul 8 TI - Validity and Reliability of the Spanish Version of the Children's Self-Perceptions of Adequacy in and Predilection for Physical Activity (CSAPPA) Questionnaire for Primary School Children Aged 6 to 12 Years. LID - 10.3390/children13070906 [doi] LID - 906 AB - INTRODUCTION: Understanding children's physical self-concept is crucial, as it influences motivation, behavior, and physical activity (PA). The Spanish version of the Children's Self-Perceptions of Adequacy in and Predilection for Physical Activity (CSAPPA) assesses the adequacy and predilection for PA, but it is not fully adapted for schoolchildren. Considering the developmental and contextual differences between children and adolescents, adapting and validating this instrument for younger populations is necessary. This study aimed to test the validity and reliability of the CSAPPA for schoolchildren aged 6-12 years (65 boys and 64 girls; mean age 9.63 +/- 1.78 years). METHOD: Comprehension of the CSAPPA was examined through cognitive interviews, and reliability was assessed via a test-retest approach with 129 Spanish schoolchildren. Confirmatory factor analysis (CFA), Cronbach's alpha, and the intraclass correlation coefficient (ICC) were used to evaluate validity and reliability. RESULTS: CFA confirmed the three-factor structure (Adequacy, Predilection, Enjoyment) in children aged 6-12, with excellent fit indices: Chi-square divided by degrees of freedom (chi(2)/df) = 1.179; Root Mean Square Error of Approximation (RMSEA) = 0.037; Comparative Fit Index (CFI) = 0.961; Tucker-Lewis Index (TLI) = 0.953. Test-retest reliability ranged from questionable to good (Cronbach's alpha = 0.622-0.871), except for items 8 and 14. The ICC values indicated moderate to near-perfect (ICC: 0.453-0.871) temporal stability; items 8 and 14 were excluded. CONCLUSIONS: The Spanish CSAPPA demonstrates validity and reliability for assessing self-perceptions related to PA motivation among schoolchildren aged 6-12. As part of the affective domain in the Spanish Physical Literacy Assessment for Children (SPLA-C) model, it shows promise for use in school and sport contexts, supporting the identification of needs and planning interventions to promote active participation and positive development. However, items 8 and 14 demonstrated poor psychometric performance and should be interpreted with caution, requiring further refinement before the instrument can be recommended without reservation. FAU - Pastor-Cisneros, Raquel AU - Pastor-Cisneros R AUID- ORCID: 0000-0001-7305-6783 AD - Physical Activity for Education, Performance and Health (PAEPH) Research Group, Faculty of Sport Sciences, University of Extremadura, 10003 Caceres, Spain. FAU - Mendoza-Munoz, Maria AU - Mendoza-Munoz M AUID- ORCID: 0000-0001-9502-5486 AD - Department of Communication and Education, Universidad Loyola Andalucia, 41704 Sevilla, Spain. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AUID- ORCID: 0000-0002-7412-7624 AD - School of Medicine, Universidad Espiritu Santo, Samborondon 0901952, Ecuador. AD - Faculty of Health Sciences, Universidad Autonoma de Chile, Temuco 4780000, Chile. FAU - Carlos-Vivas, Jorge AU - Carlos-Vivas J AUID- ORCID: 0000-0002-6377-9950 AD - Physical Activity for Education, Performance and Health (PAEPH) Research Group, Faculty of Sport Sciences, University of Extremadura, 10003 Caceres, Spain. LA - eng PT - Journal Article DEP - 20260708 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13406152 OTO - NOTNLM OT - educational assessment OT - motivation OT - physical education OT - young children COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/08 CRDT- 2026/07/28 01:01 PHST- 2026/06/02 00:00 [received] PHST- 2026/07/01 00:00 [revised] PHST- 2026/07/04 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - children13070906 [pii] AID - children-13-00906 [pii] AID - 10.3390/children13070906 [doi] PST - epublish SO - Children (Basel). 2026 Jul 8;13(7):906. doi: 10.3390/children13070906. PMID- 42509924 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 7 DP - 2026 Jul 6 TI - Chronic Skin Disease, Media Use and Health Values in the Quality of Life of Adolescents. LID - 10.3390/children13070899 [doi] LID - 899 AB - INTRODUCTION: Chronic dermatological diseases that appear in adolescence, such as acne vulgaris, atopic dermatitis, alopecia areata and psoriasis vulgaris, not only cause physical symptoms but also significantly affect young people's quality of life, mental state, self-esteem and social relationships. Social media, especially information spread by influencers, significantly influences adolescents' body image, health-related attitudes and even the quality of the physician-patient relationship. The aim of our study was to explore the relationships between dermatology-related quality of life, media use, health values, body image and self-esteem among adolescents with chronic dermatological diseases. METHODS: In our cross-sectional, quantitative study, we used validated questionnaires (DLQI, EQ-5D-5L, IRVS, Attitude Scale, STAI-Y2, SWLS-H, Rosenberg Scale, BAT), which we supplemented with a media consumption questionnaire of our own design. Structured data collection took place between October 2024 and March 2025, with the participation of 208 adolescents aged 11-18. Data analysis was performed using SPSS 26.0 (Spearman's correlation, Mann-Whitney test). Differences were considered significant at p < 0.05. Ethical approval: BM/22429-1/2024. RESULTS: Acne vulgaris was the most common diagnosis (65%), followed by atopic dermatitis (22%) and psoriasis (11%). Over a quarter of the adolescents (27%) followed influencers who provided skincare advice. The mean daily screen time was 4.5 h, with 3.7 h on smartphones. A longer screen time was significantly correlated with poorer dermatological quality of life. Greater dermatology-related quality of life impairment (higher DLQI scores) was associated with poorer general quality of life (EQ-5D-5L). Following skincare-related influencers was significantly associated with dermatology-related quality of life and anxiety. Conversely, stronger health values were significantly linked to more favourable health behaviors. CONCLUSIONS: In this sample, greater dermatology-related quality-of-life impairment was associated with poorer psychosocial outcomes. Longer screen time was associated with poorer dermatology-related quality of life and less favourable psychosocial outcomes. The novelty of our study lies in the use of a self-developed media consumption questionnaire, which is suitable for the complex mapping of psychological and quality-of-life factors in adolescents. FAU - Dinnyes, Katalin Julianna AU - Dinnyes KJ AUID- ORCID: 0000-0002-1975-7535 AD - Health Behaviour and Development Group, Faculty of Health Sciences and Social Training, University of Szeged, H-6726 Szeged, Hungary. AD - Doctoral School of Education and Society, University of Pecs, H-7622 Pecs, Hungary. FAU - Csoma, Zsanett Renata AU - Csoma ZR AD - Health Behaviour and Development Group, Faculty of Health Sciences and Social Training, University of Szeged, H-6726 Szeged, Hungary. AD - Department of Dermatology and Allergology, Albert Szent-Gyorgyi Clinical Center, University of Szeged, H-6720 Szeged, Hungary. LA - eng PT - Journal Article DEP - 20260706 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13406771 OTO - NOTNLM OT - adolescents OT - body image OT - dermatology OT - health values OT - psychodermatology OT - quality of life OT - screen time OT - self-esteem OT - social media use COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/06 CRDT- 2026/07/28 01:01 PHST- 2026/04/26 00:00 [received] PHST- 2026/06/30 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/07/06 00:00 [pmc-release] AID - children13070899 [pii] AID - children-13-00899 [pii] AID - 10.3390/children13070899 [doi] PST - epublish SO - Children (Basel). 2026 Jul 6;13(7):899. doi: 10.3390/children13070899. PMID- 42509878 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 7 DP - 2026 Jun 24 TI - Do School Athletes Really Eat Better? Nutritional and Body Composition Differences in Saudi Adolescents. LID - 10.3390/children13070852 [doi] LID - 852 AB - Background: Obesity among Saudi adolescents has risen sharply, yet whether school athletic participation is associated with students showing improved dietary habits and better anthropometric profiles compared to those of their non-athlete peers remains unclear. This study compared anthropometric indices and dietary habits between school athletes and non-athletes in Riyadh. Methods: A cross-sectional study was conducted with 124 male secondary school students (70 athletes and 54 non-athletes aged 16-17 years) in Riyadh, Saudi Arabia. Athletes were defined as students who reported engaging in vigorous-intensity sport for >/=3 days/week for >/=60 min/session. BMI, body weight, and waist circumference were measured objectively. Dietary habit frequencies across ten food categories were assessed using the validated Arab Teens Lifestyle Study (ATLS) questionnaire. Independent samples t-tests and chi-square tests were used; effect sizes were calculated as Cohen's d. A Bonferroni-corrected threshold (p < 0.005) was applied for multiple dietary comparisons. Results: Athletes had significantly lower BMI (23.64 +/- 5.39 vs. 30.28 +/- 7.25 kg/m(2); p < 0.001, d = 1.06), body weight (p < 0.001, d = 0.93), and waist circumference (85.46 +/- 12.61 vs. 95.50 +/- 17.89 cm; p < 0.001, d = 0.66). Obesity prevalence was 15.7% among athletes versus 51.9% among non-athletes. Of ten dietary variables, only fresh fruit consumption showed a between-group difference (62.9% vs. 40.7% high-frequency; p = 0.010), which did not survive Bonferroni correction. Conclusions: School athletes demonstrated substantially better anthropometric profiles than their non-athlete peers, but dietary habit frequencies were largely similar across both groups. The high obesity prevalence among non-athletes underscores the need for school-based programs that combine structured physical activity with targeted nutrition education. FAU - Alshuwaier, Ghareeb O AU - Alshuwaier GO AUID- ORCID: 0000-0003-3269-9509 AD - Department of Exercise Physiology, College of Sport Sciences and Physical Activity, King Saud University, Riyadh 11451, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260624 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13406725 OTO - NOTNLM OT - Arab adolescents OT - Saudi Vision 2030 OT - central obesity OT - cross-sectional study OT - food frequency OT - overweight OT - physical inactivity OT - school sport COIS- The author declares no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/06/24 CRDT- 2026/07/28 01:01 PHST- 2026/05/26 00:00 [received] PHST- 2026/06/15 00:00 [revised] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - children13070852 [pii] AID - children-13-00852 [pii] AID - 10.3390/children13070852 [doi] PST - epublish SO - Children (Basel). 2026 Jun 24;13(7):852. doi: 10.3390/children13070852. PMID- 42509874 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 7 DP - 2026 Jun 24 TI - Effectiveness of a School Physician-Led Counseling Intervention on Cholesterol Levels and Lifestyle Behaviors in Children with Hypercholesterolemia: A Randomized Controlled Trial. LID - 10.3390/children13070848 [doi] LID - 848 AB - Background: This randomized controlled trial aimed to evaluate the effects of a school physician-led counseling intervention on total cholesterol (TC) levels, adherence to the Mediterranean diet, physical activity, and sedentary behavior in children aged 6-7 years with elevated cholesterol levels in a Mediterranean setting. Methods: A one-year randomized controlled study was conducted among children aged 6-7 years with elevated TC levels, excluding those with familial hypercholesterolemia (FH). Participants were randomly assigned to either a control group (n = 38) or an intervention group (n = 39). All participants received standard care consisting of educational materials and baseline counseling, while the intervention group additionally participated in three structured follow-up counseling sessions conducted by school physicians during the one-year study period. Counseling focused on Mediterranean dietary habits, implementation of basic dietary principles in cases of elevated TC levels, promotion of physical activity, and reduction in sedentary behavior. TC levels were measured at baseline and at the end of the study. Dietary habits, physical activity, and sedentary behavior were assessed using validated questionnaires. For the primary outcome, a descriptive change-from-baseline analysis, unadjusted mean difference, the approximate 95% confidence interval, and Cohen's d effect size were calculated. Results: At baseline, no significant differences in TC levels were observed between groups (p = 0.852). After the intervention, mean TC levels were lower in the intervention group than in the control group (4.977 +/- 0.414 mmol/L vs. 5.137 +/- 0.410 mmol/L); however, the between-group difference did not reach statistical significance (p = 0.089). The unadjusted mean difference at follow-up was -0.160 mmol/L, with an approximate 95% confidence interval from -0.35 to 0.03 and a small-to-moderate effect size in favor of the intervention group (Cohen's d = -0.39). Descriptive change-from-baseline analysis showed a greater mean reduction in TC in the intervention group than in the control group (-0.364 mmol/L vs. -0.195 mmol/L). A statistically significant improvement in adherence to the Mediterranean diet was observed in the intervention group compared with the control group (p < 0.001). Favorable changes were also observed in several physical activity and sedentary behavior variables, including participation in organized physical activity, walking and running activities, and reduced television viewing and video gaming time. Given the exploratory nature of behavioral analyses and the number of physical activity and sedentary behavior outcomes examined, these findings should be interpreted cautiously. Conclusions: The school physician-led counseling intervention did not result in a statistically significant between-group difference in TC levels after one year, although the direction and magnitude of change favored the intervention group. The intervention was associated with improved adherence to the Mediterranean diet and favorable exploratory lifestyle-related behavioral changes. Nevertheless, the findings should be interpreted cautiously in light of the relatively small sample size, non-significant primary outcome, and exploratory nature of behavioral analyses. FAU - Tomelic Ercegovic, Katarina AU - Tomelic Ercegovic K AD - Department of School and Adolescent Medicine, Teaching Institute for Public Health, Split-Dalmatia County, 21000 Split, Croatia. FAU - Glavas, Josipa AU - Glavas J AUID- ORCID: 0000-0002-8032-3269 AD - Department of School and Adolescent Medicine, Teaching Institute for Public Health, Split-Dalmatia County, 21000 Split, Croatia. FAU - Sikirica, Ivana AU - Sikirica I AD - Department of School and Adolescent Medicine, Teaching Institute for Public Health, Split-Dalmatia County, 21000 Split, Croatia. FAU - Vrdoljak, Andrea AU - Vrdoljak A AD - Department of School and Adolescent Medicine, Teaching Institute for Public Health, Split-Dalmatia County, 21000 Split, Croatia. FAU - Tokic, Helena AU - Tokic H AD - Department of School and Adolescent Medicine, Teaching Institute for Public Health, Split-Dalmatia County, 21000 Split, Croatia. FAU - Perasovic, Jelica AU - Perasovic J AD - Department of School and Adolescent Medicine, Teaching Institute for Public Health, Split-Dalmatia County, 21000 Split, Croatia. FAU - Karin, Zeljka AU - Karin Z AD - Department of School and Adolescent Medicine, Teaching Institute for Public Health, Split-Dalmatia County, 21000 Split, Croatia. LA - eng PT - Journal Article DEP - 20260624 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13406426 OTO - NOTNLM OT - Mediterranean diet OT - children OT - hypercholesterolemia OT - intervention OT - physical activity OT - prevention COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/06/24 CRDT- 2026/07/28 01:01 PHST- 2026/05/28 00:00 [received] PHST- 2026/06/18 00:00 [revised] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - children13070848 [pii] AID - children-13-00848 [pii] AID - 10.3390/children13070848 [doi] PST - epublish SO - Children (Basel). 2026 Jun 24;13(7):848. doi: 10.3390/children13070848. PMID- 42509549 OWN - NLM STAT- MEDLINE DCOM- 20260728 LR - 20260813 IS - 1465-993X (Electronic) IS - 1465-9921 (Print) IS - 1465-9921 (Linking) VI - 27 IP - 1 DP - 2026 Jul 27 TI - Increased high sensitivity C-reactive protein in more severe wheeze/asthma phenotypes in child- and adulthood in ALLIANCE. LID - 10.1186/s12931-026-03840-x [doi] LID - 294 AB - BACKGROUND: The relevance of high-sensitivity C-reactive protein (hsCRP), a marker of low-grade systemic inflammation, remains unclear with regard to its association with severity and clinical outcomes in wheeze/asthma. We aimed to assess the role of hsCRP across different phenotypes and severity levels. METHODS: We studied children with preschool wheeze (>/= 2 episodes), and patients with GINA-defined asthma (school-age/adult) compared with healthy controls (HCs) in the well-characterized ALLIANCE (All Age Asthma Cohort) study. HsCRP was measured (AU5800(R)-CRP-Latex test) in 944 study participants (pediatric: n = 728; adult: n = 216) at baseline. Age-stratified analyses (age groups 0-5, 6-18, >/= 18 years) of standardized log(10)-transformed hsCRP concentrations (age, sex, BMI, site) were performed using univariable tests and regression models. The validated ASSESS score and its dimensions (exacerbations, lung function, inhaled corticosteroids, symptom control) were primary outcomes. RESULTS: Adult patients with asthma showed higher hsCRP than HCs (OR 2.22, 95% CI 1.56-3.24). Across all ages, hsCRP increased with clinical severity of wheeze/asthma. The ASSESS score correlated positively with hsCRP in patients aged >/= 6 years (R = 0.19, p = 0.007). hsCRP was increased in school-age asthmatics with prior exacerbations (OR 1.37, 95% CI 1.01-1.87), and in adult asthmatics with impaired lung function (R = 0.2, p = 0.013). Inhaled corticosteroid use was associated with lower hsCRP in preschool wheezers (OR 0.66, 95% CI 0.50-0.85) but higher levels in adults (OR 1.99, 95% CI 1.02-4.09). CONCLUSIONS: HsCRP was increased in adult asthmatics compared to HCs and was associated with several severity-related clinical characteristics. ICS use was associated with higher hsCRP levels in adults, potentially reflecting greater disease severity, whereas ICS use in preschool wheezers was associated with lower hsCRP levels. These age-dependent effects may mirror varying disease courses across the lifespan and progression of asthma. The association of hsCRP with asthma severity in child- and adulthood may indicate its potential relevance for the course of disease and monitoring clinical outcomes. Future longitudinal studies are needed to assess, whether hsCRP may support therapy monitoring. TRIAL REGISTRATION: ClinicalTrials.gov; Pediatric arm: NCT02496468, Registration date: 03 July 2015; Adult arm: NCT02419274, Registration date: 14 April 2015. CI - (c) 2026. The Author(s). FAU - Lagally, Lena AU - Lagally L AUID- ORCID: 0009-0001-9798-9737 AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. AD - Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Pettenkofer School of Public Health, Munich, Germany. FAU - Ullemeyer, Lena AU - Ullemeyer L AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. FAU - Omony, Jimmy AU - Omony J AUID- ORCID: 0000-0001-9983-1039 AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. AD - Institute for Asthma and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. FAU - Gottschau, Kristina AU - Gottschau K AUID- ORCID: 0000-0002-0785-9964 AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. FAU - Foppiano, Francesco AU - Foppiano F AUID- ORCID: 0009-0002-5650-9984 AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Pettenkofer School of Public Health, Munich, Germany. FAU - Abdo, Mustafa AU - Abdo M AD - LungenClinic Grosshansdorf GmbH, Grosshansdorf, Germany. AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany. AD - Department of Pneumology and Critical Care Medicine, Thoraxklinik at Heidelberg University Hospital, Translational Lung Research Center Heidelberg, Heidelberg, Germany. FAU - Veith, Vera AU - Veith V AUID- ORCID: 0009-0002-8731-9702 AD - LungenClinic Grosshansdorf GmbH, Grosshansdorf, Germany. AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany. FAU - Tholken, Clemens AU - Tholken C AUID- ORCID: 0000-0003-4328-9193 AD - Center for Synthetic Microbiology (SYNMIKRO), Philipps-Universitat Marburg, Marburg, Germany. FAU - Hose, Alexander AU - Hose A AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. FAU - Maison, Nicole AU - Maison N AUID- ORCID: 0000-0002-8731-4218 AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. AD - Institute for Asthma and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. FAU - Grychtol, Ruth AU - Grychtol R AUID- ORCID: 0000-0002-8084-104X AD - Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany. AD - Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany. FAU - Dittrich, Anna-Maria AU - Dittrich AM AUID- ORCID: 0000-0002-9582-1025 AD - Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany. AD - Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany. AD - Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany. FAU - Riemann, Lennart AU - Riemann L AUID- ORCID: 0000-0002-7188-5227 AD - Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany. AD - Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany. AD - Institute of Immunology, Hannover Medical School, Hannover, Germany. FAU - Weckmann, Markus AU - Weckmann M AUID- ORCID: 0000-0001-5342-979X AD - University Children's Hospital, Luebeck, Germany. AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Luebeck, Germany. AD - Division of Epigenetics in Chronic Lung Disease, Priority Area Chronic Lung Diseases, Leibniz Lung Center, Research Center Borstel, Borstel, Germany. FAU - Konig, Inke AU - Konig I AUID- ORCID: 0000-0003-0504-6465 AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Luebeck, Germany. AD - Institute for Medical Biometry and Statistics, University Luebeck, University Medical Centre Schleswig-Holstein, Campus Luebeck, Luebeck, Germany. FAU - Kronziel, Lea AU - Kronziel L AUID- ORCID: 0000-0002-2126-6831 AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Luebeck, Germany. AD - Institute for Medical Biometry and Statistics, University Luebeck, University Medical Centre Schleswig-Holstein, Campus Luebeck, Luebeck, Germany. FAU - Illi, Sabina AU - Illi S AUID- ORCID: 0000-0003-4994-7732 AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. AD - Institute for Asthma and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. FAU - van Koningsbruggen-Rietschel, Silke AU - van Koningsbruggen-Rietschel S AUID- ORCID: 0000-0002-2222-4238 AD - Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. FAU - Rabe, Klaus F AU - Rabe KF AUID- ORCID: 0000-0002-7020-1401 AD - LungenClinic Grosshansdorf GmbH, Grosshansdorf, Germany. AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany. FAU - Renz, Harald AU - Renz H AUID- ORCID: 0000-0003-0602-7215 AD - Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University of Marburg, Marburg, Germany. AD - University of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Giessen, Germany. FAU - Hansen, Gesine AU - Hansen G AUID- ORCID: 0000-0001-5185-9454 AD - Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany. AD - Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany. AD - Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany. FAU - Brinkmann, Folke AU - Brinkmann F AUID- ORCID: 0000-0002-4307-4232 AD - University Children's Hospital, Luebeck, Germany. AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Luebeck, Germany. FAU - Kopp, Matthias V AU - Kopp MV AUID- ORCID: 0000-0003-1989-5492 AD - University Children's Hospital, Luebeck, Germany. AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Luebeck, Germany. AD - Department of Paediatric Respiratory Medicine, Inselspital, University Children's Hospital of Bern, University of Bern, Bern, Switzerland. FAU - von Mutius, Erika AU - von Mutius E AUID- ORCID: 0000-0002-8893-4515 AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. AD - Institute for Asthma and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. FAU - Bahmer, Thomas AU - Bahmer T AUID- ORCID: 0000-0002-7677-7057 AD - LungenClinic Grosshansdorf GmbH, Grosshansdorf, Germany. AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany. FAU - Ege, Markus AU - Ege M AUID- ORCID: 0000-0001-6643-3923 AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. AD - Institute for Asthma and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. FAU - Skevaki, Chrysanthi AU - Skevaki C AUID- ORCID: 0009-0006-7522-3294 AD - Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University of Marburg, Marburg, Germany. AD - University of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Giessen, Germany. AD - Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, USA. AD - Centre for Research and Education in Public Health (CEPHRE), Academy of Athens, Athens, Greece. FAU - Schaub, Bianca AU - Schaub B AUID- ORCID: 0000-0003-1652-8873 AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. Bianca.Schaub@med.uni-muenchen.de. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. Bianca.Schaub@med.uni-muenchen.de. AD - German Center for Child and Adolescent Health (DZKJ), Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. Bianca.Schaub@med.uni-muenchen.de. CN - ALLIANCE Study Group LA - eng SI - ClinicalTrials.gov/NCT02496468 SI - ClinicalTrials.gov/NCT02419274 PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20260727 PL - England TA - Respir Res JT - Respiratory research JID - 101090633 RN - 0 (Biomarkers) RN - 9007-41-4 (C-Reactive Protein) SB - IM MH - Adolescent MH - Adult MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Middle Aged MH - Young Adult MH - *Asthma/blood/diagnosis/epidemiology MH - Biomarkers/blood MH - *C-Reactive Protein/metabolism MH - Cohort Studies MH - *Phenotype MH - *Respiratory Sounds/diagnosis/physiopathology MH - *Severity of Illness Index PMC - PMC13412301 OTO - NOTNLM OT - Asthma OT - Asthma treatment OT - Clinical immunology OT - Epidemiology OT - Inflammation OT - Pediatrics OT - Wheeze COIS- Declarations. Ethics approval and consent to participate: This study involved human participants. A statement within the Methods section to confirm that informed consent was obtained is provided. The study was approved by local ethics committees (lead: University of Luebeck Ethics Committee; reference no. AZ 12-215) and conducted in accordance with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: LU, LL, JO, KG, FF, MA, VV, CT, AH, NM, LR, IK, LK, SI, HR, FB have nothing to declare. This work was supported by German Center for Lung Research (DZL) (RG, AMD, KR, GH, MK, ME, EvM, TB, CS, BS); German Federal Ministry of Education and Research (BMBF) (AMD, TB, EvM, GH) and RG: Else-Kroner Fresenius Stiftung; AMD: Vertex Pharmaceutical Inc., German Science Foundation, GSK, Oxford University, Novartis, Hogrefe Publishing Company, Department for Pediatric Psychology, Philipps University Marburg, Vertex Pharmaceuticals, StreamedUP, Christiane-Herzog-Foundation, Austrian Society for Rare Disease, Paul-Ehrlich-Institute, German CF Patient Advocacy Board, German CF Clinical Trial Network Executive Committee, ECFS CTN Executive Committee; MW: DFG, HORIZON-MSCA-2023, COVID-19 Research Initiative Schleswig-Holstein, Follow-Up of Respiratory Infections in Schleswig-Holstein (FRISH), intramural funding of the Christian-Albrechts-University Kiel, the University of Lubeck, and the Leibniz Lung Center, Research Center Borstel; SvKR: Wilsing Stiftung Koln; KR: AstraZeneca, Boehringer Ingelheim, Chiesie, Sanofi & Regeneron, Astra Zeneca, Chiesi Pharmaceuticals, CSL Behring, GlaxoSmithKline, Berlin Chemie, Menarini, German Chest Society (DGP), American Thoracic Society (ATS); GH: Sanofi GmbH, MedUpdate, Abbvie; MK: University of Bern, Allergopharma GmbH, Sanofi Aventis GmbH, Infectopharm GmbH, Gesellschaft Padiatrische Pneumologie e.V; EvM: Bavarian State Ministry of Health and Care for "URS Study", Go Bio Initial Grant, BMBF (Federal Ministry of Education and Research), European Research Council Award, "BEAR Study", O.M. Pharma S.A.; Elsevier GmbH, Georg Thieme Verlag, Springer-Verlag GmbH, Elsevier Ltd., Springer Nature Group, Deutscher Apotheker Verlag; Chinese University of Hongkong, European Commission, AstraZeneca, Imperial College London, OM Pharma S.A., Clarivate; ALK-Abello Arzneimittel GmbH, Japanese Society of Pediatric Allergy and Clinical Immunology (JSPACI), Klinikum Rechts der Isar, University of Colorado, Paul-Martini-Stiftung, Astra Zeneca BioPharmaceuticals Medical, Imperial College London, Children s Hospital Research, Institute of Manitoba Kompetenzzentrum fur Ernahrung (Kern), OM Pharma S.A., Swedish Pediatric Society for Allergy and Lung Medicine, Chinese College of Allergy and Asthma (CCAA), Abbott Laboratories, Deutscher Apotheker Verlag GmbH & Co. KG, Socieded Chilena de Enfermedades Respiratorias, Japanese Society of Allergology, British Society for Asthma and Clinical Immunology, American Academy of Allergy, Asthma & Immunology, European Respiratory Society (ERS), Ludwig Maximilians University Munich, French Health Research Programs' Agency, CONSORZIO FUTURO IN RICERCA, Technical University of Munich (TUM); Deutsches Zentrum fur Lungenforschung (DZL), Fabio Luigi Massimo Ricciardolo/Contatto S.r.l., Fraunhofer ITEM Hannover, MCCA Institut fur Immunologie Uni Wien, Karl-Landsteiner Privatuniversitat f. Gesundheitswissenschaften, Swiss Institute of Allergy and Asthma Research (SIAF) Davos (Associated Institute of the University of Zurich) MHH (Medizinische Hochschule Hannover), Natasha Allergy Research Foundation, Deutsche Forschungsgemeinschaft, Gordon Research Conferences, Socieded Chilena de Enfermedades Respiratorias, Arla, Universitat Leiden, OM Pharma S.A., American Academy of Allergy, Asthma & Clinical Immunology, Deutsche Forschungsgemeinschaft (DFG), European Respiratory Society (ERS), Deutsche Gesellschaft fur Kinder- und Jugendmedizin, World Allergy Organization (WAO), European Parliament, Gesellschaft fur Padiatrische Pneumologie (GPP), European Academy of Allergy and Clinical Immunology (EAACI), Helmholtz Association of German Research Centres, Nobel Conference Stockholm, AAA Congress Sarajevo, Karolinska Institutet, Balzan Foundation, Fondazione Menarini, International Union of Immunological Societies (IUIS), Deutsche Gesellschaft fur Allergologie und klinische Immunologie (DGAKI), Collegium Internationale Allergologicum, European Academy of Allergy & Clinical Immunology (EAACI); EvM has patent No. PCT/EP2019/085016 (Barn dust extract for the prevention and treatment of diseases) issued EU, pending US, Royalties paid to ProtectImmun for patent EP2361632 (Speci fi c environmental bacteria for the protection from and/or the treatment of allergic, chronic in fl ammatory and/or autoimmune disorders, granted on 19 March 2014), and patents EP1411977 (Composition containing bacterial antigens used for the prophylaxis and the treatment of allergic diseases, granted on 18 April 2007), EP1637147 (Stable dust extract for allergy protection, granted on 10 December 2008), and EP 1964570 (Pharmaceutical compound to protect against allergies and in fl ammatory diseases, granted on 21 November 2012) licensed to ProtectImmun. Patent EP21189353.2. 2021. von Mutius E, Rankl B, Bracher F, Muller C, Walker A, Hauck SM, Merl-Pham J, inventors; PROTEINS IDENTIFIED FROM BARN DUST EXTRACT FOR THE PREVENTION AND TREATMENT OF DISEASES. Patent PCT/US2021/016918. 2021. Martinez FD, Vercelli D, Snyder SA, von Mutius E, Pivniouk V, Marques dos Santos M, inventors; THERAPEUTIC FRACTIONS AND PROTEINS FROM ASTHMA-PROTECTIVE FARM DUST. Patent EP21189353.2. 2021. von Mutius E, Rankl B, Bracher F, Muller C, Walker A, Hauck SM, Merl-Pham J, Adler H, Yildirim A.O., Sattler M, Santos Dias Mourao A, Borggrafe J, O Connor P.D., Plettenburg O, inventors; PROTEINS IDENTIFIED FROM BARN DUST EXTRACT FOR THE PREVENTION AND TREATMENT OF DISEASES. Member of the BEAMS External Scientific Advisory Board (ESAB), Member of the Editorial Board of "The Journal of Allergy and Clinical Immunology: In Practice", Member of the Scientific Advisory Board of the Children's Respiratory and Environmental Workgroup (CREW), Member of the International Scientific & Societal Advisory Board (ISSAB) of Utrecht Life Sciences (ULS) University of Utrecht, Member of External Review Panel of the Faculty of Veterinary Science, University of Utrecht, Member of the Selection Committee for the Gottfried Wilhelm Leibniz Programme (DFG), Member of the International Advisory Board of "The Lancet Respiratory Medicine", Member of the Scientific Advisory Board of the CHILD (Canadian Healthy Infant Longitudinal Development) study, McMaster University, Hamilton, Canada, Member of the Pediatric Scientific Advisory Board Iceland, Member of the Abbott Allergy Risk Reduction Advisory Board, Member of the HpVac Scientific Advisory Board, Member of the OM Pharma Scientific Advisory Board, Member of the Award Committee of the International Balzan Foundation, Member of the Scientific Advisory Board for French Prevention National Research Programme, Member of the Scientific Advisory Panel for The Natasha Allergy Research Foundation; TB: Network University Medicine (NUM), Thieme, HealthHero, PneumoLounge, Pohl Boskamp, Pfizer, Chiesi, AstraZeneca, PohlBoskamp, German Society for Pneumology (DGP); ME: Latvian Council of Science, Travel Grant by the International Milk Genomics Consortium 2023 and by Dutch Longfunds 2025; CS: Consultancy and research funding, Bencard Allergie; Consultancy, Novartis Pharma GmbH; BS: GlaxoSmithKline, Novartis, Sanofi, Astra Zeneca, DGAKI. FIR - Burk, Mira IR - Burk M FIR - Contento, Sybille IR - Contento S FIR - Gschwendtner, Silvia IR - Gschwendtner S FIR - Jakwerth, Constanze IR - Jakwerth C FIR - Schloter, Michael IR - Schloter M FIR - Schmidt-Weber, Carsten IR - Schmidt-Weber C FIR - Zeitlmann, Esther IR - Zeitlmann E FIR - Biller, Heike IR - Biller H FIR - Blanke-Roeser, Constantin IR - Blanke-Roeser C FIR - Gaede, Karoline I IR - Gaede KI FIR - Hagedorn, Wiebke IR - Hagedorn W FIR - Jacobs, Nikolas IR - Jacobs N FIR - Kirsten, Anne-Marie IR - Kirsten AM FIR - Nissen, Gyde IR - Nissen G FIR - Nurieva, Wasifa IR - Nurieva W FIR - Pedersen, Frauke IR - Pedersen F FIR - Penner, Loana IR - Penner L FIR - Ricklefs, Isabell IR - Ricklefs I FIR - Szymczak, Silke IR - Szymczak S FIR - Waschki, Benjamin IR - Waschki B FIR - Watz, Henrik IR - Watz H FIR - Wirks, Christopher IR - Wirks C FIR - Bickes, Marie IR - Bickes M FIR - Calvero, Mifflin-Rae IR - Calvero MR FIR - DeLuca, David S IR - DeLuca DS FIR - Gaedcke, Svenja IR - Gaedcke S FIR - Habener, Anika IR - Habener A FIR - Happle, Christine IR - Happle C FIR - Jirmo, Adan Chari IR - Jirmo AC FIR - Liu, Bin IR - Liu B FIR - Foth, Svenja IR - Foth S FIR - Jerrentrup, Inga IR - Jerrentrup I FIR - Weber, Stefanie IR - Weber S FIR - Alejandre Alcazar, Miguel A IR - Alejandre Alcazar MA FIR - Keufken, Lena IR - Keufken L FIR - Rietschel, Ernst IR - Rietschel E FIR - Trojan, Tobias IR - Trojan T FIR - Thomassen, Jan-Christoph IR - Thomassen JC EDAT- 2026/07/28 00:35 MHDA- 2026/07/28 06:37 PMCR- 2026/07/27 CRDT- 2026/07/27 23:35 PHST- 2026/05/04 00:00 [received] PHST- 2026/07/16 00:00 [accepted] PHST- 2026/07/28 06:37 [medline] PHST- 2026/07/28 00:35 [pubmed] PHST- 2026/07/27 23:35 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - 10.1186/s12931-026-03840-x [pii] AID - 3840 [pii] AID - 10.1186/s12931-026-03840-x [doi] PST - epublish SO - Respir Res. 2026 Jul 27;27(1):294. doi: 10.1186/s12931-026-03840-x. PMID- 42506838 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260727 LR - 20260813 IS - 2075-4663 (Electronic) IS - 2075-4663 (Linking) VI - 14 IP - 7 DP - 2026 Jul 10 TI - Association Between Physical Activity and Mental Health in Primary School Children. LID - 10.3390/sports14070295 [doi] LID - 295 AB - Mental health during childhood is a major public health concern, and physical activity has been proposed as a modifiable behaviour associated with psychological well-being and emotional health. This study examined the associations between physical activity and mental health indicators, including psychological well-being, anxiety symptoms, and everyday stress, in primary school children. A cross-sectional study was conducted with 207 children from two schools in Jaen (Spain). Physical activity, psychological well-being, anxiety, and stress were assessed using validated questionnaires. Pearson correlations and multiple linear regression analyses adjusted for age, sex, and socioeconomic status were performed. Physical activity was positively associated with all dimensions of psychological well-being and with total psychological well-being (r = 0.182, p = 0.009). Significant inverse correlations were observed between physical activity and all anxiety dimensions, as well as total anxiety (r = -0.145, p = 0.037), although the association with total anxiety was not significant after adjustment (beta = -0.149, p = 0.112). Physical activity was also negatively associated with all stress dimensions and remained significantly associated with lower total stress after adjustment (beta = -0.253, p = 0.007). These findings indicate that higher levels of physical activity are associated with greater psychological well-being and lower everyday stress in primary school children. However, given the cross-sectional design, these associations should not be interpreted as causal relationships. Longitudinal studies are needed to clarify the directionality of these associations. FAU - Lendinez-Conejo, Raul AU - Lendinez-Conejo R AD - Faculty of Educational Sciences, University of Jaen, 23071 Jaen, Spain. FAU - Aibar-Almazan, Agustin AU - Aibar-Almazan A AUID- ORCID: 0000-0002-9386-9199 AD - Department of Health Sciences, Faculty of Health Sciences, University of Jaen, 35017 Jaen, Spain. FAU - Carcelen-Fraile, Maria Del Carmen AU - Carcelen-Fraile MDC AUID- ORCID: 0009-0000-9186-8865 AD - Department of Educational Sciences, Faculty of Social Sciences, University of Atlantico Medio, 35017 Las Palmas de Gran Canaria, Spain. AD - International Scientific Association on Innovation in Education and Health (ACIINES), 23007 Jaen, Spain. AD - International Network of Educational Law, 35017 Las Palmas de Gran Canaria, Spain. LA - eng PT - Journal Article DEP - 20260710 PL - Switzerland TA - Sports (Basel) JT - Sports (Basel, Switzerland) JID - 101722684 PMC - PMC13417498 OTO - NOTNLM OT - anxiety OT - childhood OT - physical activity OT - primary education OT - psychological well-being OT - stress COIS- The authors declare no conflicts of interest. EDAT- 2026/07/27 12:36 MHDA- 2026/07/27 12:37 PMCR- 2026/07/10 CRDT- 2026/07/27 09:44 PHST- 2026/06/06 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/07/27 12:37 [medline] PHST- 2026/07/27 12:36 [pubmed] PHST- 2026/07/27 09:44 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - sports14070295 [pii] AID - sports-14-00295 [pii] AID - 10.3390/sports14070295 [doi] PST - epublish SO - Sports (Basel). 2026 Jul 10;14(7):295. doi: 10.3390/sports14070295. PMID- 42506821 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260727 LR - 20260813 IS - 2075-4663 (Electronic) IS - 2075-4663 (Linking) VI - 14 IP - 7 DP - 2026 Jul 3 TI - High-Intensity Functional Concurrent Training for Physical Fitness, Body Composition, and Psychological Outcomes in Schoolchildren: Protocol for a Randomized Controlled Trial. LID - 10.3390/sports14070279 [doi] LID - 279 AB - High-intensity functional concurrent training (HIFCT) has emerged as a form of training characterized by constantly varied functional movements adapted to individual fitness levels. Previous studies have reported positive effects on muscular strength, cardiorespiratory fitness, body composition, and psychological well-being; however, evidence regarding HIFCT interventions in school-aged children remains limited. Therefore, the aim of the present study protocol is to evaluate the effects of an 8-week HIFCT programme on muscular strength, cardiorespiratory fitness, body composition, anxiety, stress, and self-esteem in children aged 10-12 years. Physical fitness, anthropometric variables, and psychological outcomes will be assessed before and after the intervention using validated field-based tests and questionnaires. This study may provide novel evidence regarding the feasibility, safety, and potential effects of HIFCT programmes in the school setting. The study protocol was registered at ClinicalTrials.gov (NCT07552844) and approved by the Cordoba Research Ethics Committee (IMIBIC, Cordoba, Spain; protocol code SICEIA-2025-000408). FAU - Duran-Lopez, Natalia AU - Duran-Lopez N AUID- ORCID: 0009-0008-5874-4519 AD - Ministry of Educational Development and Vocational Training, Regional Government of Andalusia, 41092 Sevilla, Spain. AD - Department of Psychology, Faculty of Educational Sciences and Psychology, University of Cordoba, 14004 Cordoba, Spain. FAU - Gomez-Garcia, Carlos AU - Gomez-Garcia C AUID- ORCID: 0009-0004-2735-2230 AD - Osuna University School, Teaching Center Attached to the University of Seville, 41640 Seville, Spain. FAU - Ranchal-Sanchez, Antonio AU - Ranchal-Sanchez A AUID- ORCID: 0000-0002-8655-8878 AD - Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain. AD - Department of Nursing, Pharmacology and Physiotherapy, Faculty of Medicine and Nursing, University of Cordoba, 14004 Cordoba, Spain. FAU - Lucena-Jurado, Valentina AU - Lucena-Jurado V AUID- ORCID: 0000-0002-7011-6661 AD - Department of Psychology, Faculty of Educational Sciences and Psychology, University of Cordoba, 14004 Cordoba, Spain. FAU - Moyano-Ortega, Victoria AU - Moyano-Ortega V AD - Osuna University School, Teaching Center Attached to the University of Seville, 41640 Seville, Spain. FAU - Lara-Barahona Ostos, Ana AU - Lara-Barahona Ostos A AD - Osuna University School, Teaching Center Attached to the University of Seville, 41640 Seville, Spain. FAU - Jurado-Castro, Jose Manuel AU - Jurado-Castro JM AUID- ORCID: 0000-0002-0198-2793 AD - Osuna University School, Teaching Center Attached to the University of Seville, 41640 Seville, Spain. AD - Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain. AD - CIBERobn Physiopathology of Obesity and Nutrition, Centre of Biomedical Research Network, Institute of Health Carlos III, 28029 Madrid, Spain. LA - eng SI - ClinicalTrials.gov/NCT07552844 GR - University of Cordoba OTC Transfer Contract No. 12021050/University of Cordoba/ PT - Journal Article DEP - 20260703 PL - Switzerland TA - Sports (Basel) JT - Sports (Basel, Switzerland) JID - 101722684 PMC - PMC13417676 OTO - NOTNLM OT - high-intensity functional concurrent training OT - physical fitness OT - psychological health OT - schoolchildren COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/07/27 12:36 MHDA- 2026/07/27 12:37 PMCR- 2026/07/03 CRDT- 2026/07/27 09:44 PHST- 2026/05/14 00:00 [received] PHST- 2026/06/26 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/07/27 12:37 [medline] PHST- 2026/07/27 12:36 [pubmed] PHST- 2026/07/27 09:44 [entrez] PHST- 2026/07/03 00:00 [pmc-release] AID - sports14070279 [pii] AID - sports-14-00279 [pii] AID - 10.3390/sports14070279 [doi] PST - epublish SO - Sports (Basel). 2026 Jul 3;14(7):279. doi: 10.3390/sports14070279. PMID- 42506345 OWN - NLM STAT- MEDLINE DCOM- 20260727 LR - 20260813 IS - 2076-3271 (Electronic) IS - 2076-3271 (Linking) VI - 14 IP - 3 DP - 2026 Jul 6 TI - Emotional Eating and Its Associations with the Prevalence of Depression and Anxiety Symptoms in University Students: A Cross-Sectional Study. LID - 10.3390/medsci14030376 [doi] LID - 376 AB - Background/Objectives: Emotional eating (EE) is an emerging public health concern among university students, a population exposed to heightened academic demands, psychosocial stressors, and lifestyle changes that may promote maladaptive coping behaviors. EE has been linked to psychological distress, particularly depressive and anxiety symptoms, as well as sociodemographic, lifestyle, and anthropometric factors; however, findings remain heterogeneous and insufficiently integrated within comprehensive analytical frameworks. This study aimed to examine the association between EE and depressive and anxiety symptoms in university students, while assessing the independent contributions of sociodemographic, academic, lifestyle, and anthropometric determinants. Methods: A cross-sectional survey was performed among 1279 university students from 10 regions in Greece. Sociodemographic, academic, lifestyle, and anthropometric data were collected using validated instruments and standardized procedures. Depressive and anxiety symptoms were assessed by the use of the Beck Depression Inventory-II (BDI-II) and the six-item State-Trait Anxiety Inventory (STAI-6), respectively. EE was evaluated utilizing the EE subscale of the Three-Factor Eating Questionnaire-Revised 18 (TFEQ-R18). Multivariable ordinal logistic regression models were applied to examine independent associations. Results: In fully adjusted models, depressive and anxiety symptoms were the strongest correlates of higher EE levels, each associated with more than twofold increased odds. Female sex, Greek nationality, rural residence, enrollment in biomedical sciences, later academic years, and regular smoking were also positively associated with EE. Higher physical activity was inversely associated with EE levels. Overweight, obesity, and increased waist circumference and waist-to-hip ratio were consistently linked to higher EE, with several associations exceeding twofold increased odds. Conclusions: EE in university students is strongly associated with psychological distress and clusters with adverse lifestyle and anthropometric characteristics. These findings support the need for integrated interventions targeting mental health, lifestyle behaviors, and obesity-related risk factors. Longitudinal studies are warranted to clarify causal pathways and underlying mechanisms. FAU - Alexatou, Olga AU - Alexatou O AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Lemnos, Greece. FAU - Papadopoulou, Sousana K AU - Papadopoulou SK AUID- ORCID: 0000-0002-6408-6128 AD - Department of Nutritional Sciences and Dietetics, Faculty of Health Sciences, International Hellenic University, 57400 Thessaloniki, Greece. FAU - Angelakou, Exakousti-Petroula AU - Angelakou EP AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Lemnos, Greece. FAU - Migdanis, Athanasios AU - Migdanis A AD - Laboratory of Clinical Nutrition and Dietetics (CND-Lab), Department of Nutrition and Dietetics, University of Thessaly, 42132 Trikala, Greece. FAU - Louka, Aikaterini AU - Louka A AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Lemnos, Greece. FAU - Migdanis, Ioannis AU - Migdanis I AD - Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece. AD - Oncology Clinic and Hemodialysis Unit, "E. Patsidis" Health Group, Department of Clinical Nutrition, 41335 Larissa, Greece. FAU - Mentzelou, Maria AU - Mentzelou M AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Lemnos, Greece. FAU - Koimtsidis, Theodosios AU - Koimtsidis T AD - Department of Nutritional Sciences and Dietetics, Faculty of Health Sciences, International Hellenic University, 57400 Thessaloniki, Greece. FAU - Psara, Evmorfia AU - Psara E AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Lemnos, Greece. FAU - Giaginis, Constantinos AU - Giaginis C AUID- ORCID: 0000-0003-2878-4831 AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Lemnos, Greece. LA - eng PT - Journal Article DEP - 20260706 PL - Switzerland TA - Med Sci (Basel) JT - Medical sciences (Basel, Switzerland) JID - 101629322 SB - IM MH - Humans MH - *Emotional Eating MH - Female MH - *Students/psychology MH - Cross-Sectional Studies MH - Universities MH - *Depression/epidemiology/psychology MH - Male MH - *Anxiety/epidemiology/psychology MH - Young Adult MH - Prevalence MH - Greece/epidemiology MH - Adult MH - Adolescent MH - Surveys and Questionnaires PMC - PMC13414101 OTO - NOTNLM OT - anxiety OT - depression OT - emotional eating OT - mental health OT - psychological distress OT - university students COIS- The authors declare no conflicts of interest. EDAT- 2026/07/27 12:36 MHDA- 2026/07/27 12:37 PMCR- 2026/07/06 CRDT- 2026/07/27 09:34 PHST- 2026/06/22 00:00 [received] PHST- 2026/06/29 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/07/27 12:37 [medline] PHST- 2026/07/27 12:36 [pubmed] PHST- 2026/07/27 09:34 [entrez] PHST- 2026/07/06 00:00 [pmc-release] AID - medsci14030376 [pii] AID - medsci-14-00376 [pii] AID - 10.3390/medsci14030376 [doi] PST - epublish SO - Med Sci (Basel). 2026 Jul 6;14(3):376. doi: 10.3390/medsci14030376. PMID- 42505707 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260727 LR - 20260813 IS - 2304-6767 (Electronic) IS - 2304-6767 (Linking) VI - 14 IP - 7 DP - 2026 Jul 2 TI - Who Gets Dental Caries? A Comprehensive Review. LID - 10.3390/dj14070400 [doi] LID - 400 AB - Dental caries is the world's most common non-communicable disease with a complex etiology including social, behavioral, medical, biological and economical elements. The distribution among populations and age groups is skewed, which calls for validated clinical tools to identify those with increased caries risk. The aim of this article was therefore to review risk factors for caries development in children, based on global prospective birth cohorts, genetic proceedings and data from validated risk assessment tools. The genetic elements involve four main categories comprising enamel quality, salivary composition, dental biofilm function and taste preferences. Recent studies suggest that genes may account for 35-55% of the variation in caries scores in the young permanent dentition. Prospective birth cohorts have pointed out poverty, socioeconomic level, early introduction and excessive sugar intake as significant factors for a child's dental caries trajectory up into adulthood. Moreover, prolonged breastfeeding, child obesity and maternal oral conditions are linked to the caries burden later in life. In the clinic, the strongest predictors are past caries history and selected behavioral and social factors. The performance of the validated caries risk assessment models is far from perfect, but still acceptable in terms of reliability during childhood. These tools are the best clinical practice since they add objectivity, consistency and documentation to the clinical routines. In addition, the dental staff has the advantage of using the outcome of the assessment for a structured risk communication with the caregivers. The protocol should also form the basis for a personalized intervention program addressing the entire family, with particular focus on maternal oral health and sugar reduction. FAU - Twetman, Svante AU - Twetman S AUID- ORCID: 0000-0002-0199-9210 AD - Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark. AD - Department of Paediatric Dentistry, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Papaioannou, William AU - Papaioannou W AUID- ORCID: 0000-0001-5146-4399 AD - Department of Preventive and Community Dentistry, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Gizani, Sotiria AU - Gizani S AD - Department of Paediatric Dentistry, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece. LA - eng PT - Journal Article PT - Review DEP - 20260702 PL - Switzerland TA - Dent J (Basel) JT - Dentistry journal JID - 101716125 PMC - PMC13407877 OTO - NOTNLM OT - caries trajectory OT - children OT - heredity OT - risk assessment OT - socio-economy OT - sugars COIS- The authors have no conflicts of interest to declare. This paper was entirely financed by the authors' academic institutions. EDAT- 2026/07/27 12:36 MHDA- 2026/07/27 12:37 PMCR- 2026/07/02 CRDT- 2026/07/27 09:25 PHST- 2026/05/05 00:00 [received] PHST- 2026/06/23 00:00 [revised] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/07/27 12:37 [medline] PHST- 2026/07/27 12:36 [pubmed] PHST- 2026/07/27 09:25 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - dj14070400 [pii] AID - dentistry-14-00400 [pii] AID - 10.3390/dj14070400 [doi] PST - epublish SO - Dent J (Basel). 2026 Jul 2;14(7):400. doi: 10.3390/dj14070400. PMID- 42502880 OWN - NLM STAT- MEDLINE DCOM- 20260929 LR - 20260929 IS - 1941-2452 (Electronic) IS - 0884-5336 (Linking) VI - 41 IP - 5 DP - 2026 Oct TI - Evaluation of the reliability of current neonatal malnutrition indicators in diagnosis: An analysis of a retrospective cohort. PG - 1445-1456 LID - 10.1002/ncp.70157 [doi] AB - BACKGROUND: Proposed diagnostic criteria for neonatal malnutrition have not been validated. The objective of this study was to evaluate the reliability of the 2018 neonatal malnutrition criteria for identifying malnutrition in preterm infants. METHODS: A retrospective study of premature infants admitted to a level III neonatal intensive care unit from 2013 to 2022 was performed. Malnutrition diagnoses were assigned using each indicator. Weight and linear growth velocities were defined using the preferred approach (maintaining z-score on Fenton growth chart) and generalized growth goals (weight: 15-20 g/kg/day for infants <2000 g, 20-30 g/day for infants >/=2000 g, length: 1 cm/week). Kappa (k) values assessed the inter-indicator reliability of the full criteria and the inter-indicator and intra-indicator reliability of individual malnutrition criteria. Acceptable reliability was defined as k > 0.8. RESULTS: This study included 2305 infants. The 2018 neonatal malnutrition criteria had poor inter-indicator reliability for diagnosis in the first 2 weeks of life (k = 0.054) and after the first 2 weeks (k = 0.087). Inter-indicator reliability varied but was better among growth-based indicators. Intra-indicator reliability was strong for weight gain velocity definitions (k values ranging from 0.86 to 0.94), but poor for linear growth definitions (k = 0.12). CONCLUSION: Proposed neonatal malnutrition criteria have poor reliability when all indicators are used and limited reliability at the individual indicator level. Utilization of generalized weight gain goals may be appropriate for malnutrition diagnosis, but the generalized linear growth goal of 1 cm/week is not. Differing patterns in malnutrition diagnoses should be investigated for clinical significance. Redevelopment of current indicators is likely warranted. CI - (c) 2026 American Society for Parenteral and Enteral Nutrition. FAU - Merlino Barr, Stephanie AU - Merlino Barr S AUID- ORCID: 0000-0002-0125-5684 AD - MetroHealth Medical Center, Cleveland, Ohio, USA. FAU - Hand, Rosa K AU - Hand RK AD - Case Western Reserve University, Cleveland, Ohio, USA. FAU - Collin, Marc AU - Collin M AD - MetroHealth Medical Center, Cleveland, Ohio, USA. FAU - Love, Thomas E AU - Love TE AD - MetroHealth Medical Center, Cleveland, Ohio, USA. AD - Case Western Reserve University, Cleveland, Ohio, USA. FAU - Groh-Wargo, Sharon AU - Groh-Wargo S AD - MetroHealth Medical Center, Cleveland, Ohio, USA. AD - Case Western Reserve University, Cleveland, Ohio, USA. LA - eng GR - Stephanie Merlino Barr has received compensation for creating and presenting academic materials for Abbott Nutrition Health Institute, Reckitt/Mead Johnson, and Nutricia. Dr. Groh-Wargo is on the speaker's bureau of Abbott Nutrition. Drs. Hand, Collin, and Love have no financial disclosures/ PT - Evaluation Study PT - Journal Article DEP - 20260726 PL - United States TA - Nutr Clin Pract JT - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JID - 8606733 SB - IM MH - Humans MH - Retrospective Studies MH - Infant, Newborn MH - Reproducibility of Results MH - *Infant Nutrition Disorders/diagnosis MH - Female MH - Infant, Premature/growth & development MH - Male MH - Intensive Care Units, Neonatal MH - *Nutrition Assessment OTO - NOTNLM OT - malnutrition OT - neonatal OT - premature infants OT - reliability OT - weight gain EDAT- 2026/07/26 06:42 MHDA- 2026/09/29 12:27 CRDT- 2026/07/26 04:12 PHST- 2026/06/04 00:00 [revised] PHST- 2025/09/22 00:00 [received] PHST- 2026/06/20 00:00 [accepted] PHST- 2026/09/29 12:27 [medline] PHST- 2026/07/26 06:42 [pubmed] PHST- 2026/07/26 04:12 [entrez] AID - 10.1002/ncp.70157 [doi] PST - ppublish SO - Nutr Clin Pract. 2026 Oct;41(5):1445-1456. doi: 10.1002/ncp.70157. Epub 2026 Jul 26. PMID- 42501948 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260916 IS - 1938-3207 (Electronic) IS - 0002-9165 (Print) IS - 0002-9165 (Linking) VI - 124 IP - 3 DP - 2026 Sep TI - The validity of measuring energy and nutrient intake with the Remote Food Photography Method (RFPM) in adolescents. PG - 101452 LID - S0002-9165(26)00261-3 [pii] LID - 10.1016/j.ajcnut.2026.101452 [doi] AB - BACKGROUND: The remote food photography method (RFPM) accurately estimates energy intake (EI) in adults, but its validity in adolescents has yet to be tested. Given the low accuracy of self-reported dietary intake in adolescents, evaluating the validity of the RFPM in both controlled and free-living settings is crucial. OBJECTIVES: To examine the validity of the RFPM in estimating adolescents' EI in controlled and free-living settings. METHODS: In Study 1, adolescents (n = 45) used the RFPM/SmartIntake application during 1) a laboratory test meal, 2) a cafeteria meal, and 3) 7 d of free-living intake, with EI estimations validated against weighed food intake, digital photography of foods method, and doubly labeled water, respectively. EI was measured under the same 3 settings with pen-and-paper food records. After refining the application and training, Study 2 (n = 22) repeated the protocol with a 3-d free-living period. For both studies, equivalence was evaluated using two one-sided t-tests (+/-10% bounds), and linear mixed models assessed RFPM error by participant characteristics. RESULTS: In Study 1, RFPM estimates of EI were equivalent to the criterion measure during cafeteria meals [mean standard deviation (SD) error: 4.1 (120.8) kcal; P = 0.005] but were not equivalent for the laboratory test meal [mean (SD) error: 61.1 (112.7) kcal; P = 0.675] and 7 d of free-living intake [mean (SD) error: -887.9 (554.8) kcal/d; P > 0.99]. In Study 2, RFPM EI estimates were equivalent to the criterion measure in the controlled setting [mean (SD) error: -2.2 (86.5) kcal; P = 0.007], but not in free-living settings [mean (SD) error: -782.8 (947.0) kcal/d; P = 0.99]. In both studies, a higher body mass index (in kg/m(2)) percentile was associated with greater underestimation of EI (both R(2) > 0.19 and P < 0.05). CONCLUSIONS: The RFPM can accurately estimate the meal-level EI of adolescents in controlled settings; however, significant underestimation occurred in free-living settings in both studies. Previous studies demonstrated the inability to accurately assess adolescents' free-living intake, and the current results extend these findings to the RFPM. This trial was registered at clinicaltrials.gov as Study 1: NCT01719445 (https://clinicaltrials.gov/study/NCT01719445) and Study 2: NCT04148560 (https://clinicaltrials.gov/study/NCT04148560). CI - Copyright (c) 2026 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Hochsmann, Christoph AU - Hochsmann C AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States; Department of Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Diktas, Hanim E AU - Diktas HE AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Myers, Candice A AU - Myers CA AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Dorling, James L AU - Dorling JL AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States; Human Nutrition, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom. FAU - Rood, Jennifer C AU - Rood JC AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Greenway, Frank AU - Greenway F AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Champagne, Catherine M AU - Champagne CM AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Apolzan, John W AU - Apolzan JW AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Martin, Corby K AU - Martin CK AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. Electronic address: corby.martin@pbrc.edu. LA - eng SI - ClinicalTrials.gov/NCT04148560 SI - ClinicalTrials.gov/NCT01719445 GR - R01 DK089051/DK/NIDDK NIH HHS/United States GR - F32 HD116537/HD/NICHD NIH HHS/United States GR - P30 DK072476/DK/NIDDK NIH HHS/United States GR - T32 DK064584/DK/NIDDK NIH HHS/United States GR - U54 GM104940/GM/NIGMS NIH HHS/United States PT - Clinical Trial PT - Journal Article PT - Validation Study DEP - 20260725 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - Diet Records MH - *Energy Intake MH - Nutrition Assessment MH - *Photography/methods MH - Reproducibility of Results PMC - PMC13573646 MID - NIHMS2206243 OTO - NOTNLM OT - RFPM OT - adolescents OT - dietary assessment OT - doubly labeled water OT - energy intake OT - remote food photography method COIS- Conflict of interest The intellectual property surrounding the remote food photography method and SmartIntake application is owned by Louisiana State University/Pennington Biomedical, and CKM is an inventor of the technology and is employed by Louisiana State University/Pennington Biomedical. All other authors report no conflicts of interest. EDAT- 2026/07/26 00:42 MHDA- 2026/09/01 23:34 PMCR- 2026/09/14 CRDT- 2026/07/25 19:13 PHST- 2026/03/18 00:00 [received] PHST- 2026/06/24 00:00 [revised] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/09/01 23:34 [medline] PHST- 2026/07/26 00:42 [pubmed] PHST- 2026/07/25 19:13 [entrez] PHST- 2026/09/14 00:00 [pmc-release] AID - S0002-9165(26)00261-3 [pii] AID - 10.1016/j.ajcnut.2026.101452 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Sep;124(3):101452. doi: 10.1016/j.ajcnut.2026.101452. Epub 2026 Jul 25. PMID- 42499772 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260829 LR - 20260829 IS - 2574-2272 (Electronic) IS - 2096-3726 (Print) IS - 2574-2272 (Linking) VI - 10 IP - 4 DP - 2026 Aug TI - Evidence map and gap analysis of metabolic change in pediatric growth hormone deficiency treated with growth hormone. PG - 359-373 LID - 10.1002/ped4.70050 [doi] AB - IMPORTANCE: Recombinant human growth hormone (rhGH) improves height in children with growth hormone deficiency (GHD). However, its metabolic effects remain unclear. OBJECTIVE: To synthesize evidence regarding the metabolic effects of rhGH or growth hormone (GH) derivatives in GHD, identify knowledge gaps, and highlight future research priorities. METHODS: PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure, China Biology Medicine disc, and Wanfang databases were searched in July 2023 to identify studies on metabolic effects of GH treatment. Bubble plots were used to visualize GH treatment effects on metabolic parameters according to treatment duration by comparison with baselines, nonpharmacological interventions, and healthy controls. Random-effects meta-analyses were conducted for outcomes with inconsistent findings across original studies when randomized controlled trial data were sufficient. The study was registered with INPLASY (INPLASY202450064). RESULTS: Sixty-three studies (6158 participants) analyzed the effects of GH treatment on metabolic outcomes in children with GHD. Overall, GH treatment slightly affected glucose levels; lipid effects were inconsistent. GH treatment did not influence bone mineral density, bone mineral content, or parathyroid hormone levels. Most studies showed no significant effects on thyroid hormone levels, body composition, or body mass index (BMI). GH treatment may increase serum asymmetric dimethylarginine and gastrin levels while reducing tumor necrosis factor and serum urea levels. INTERPRETATION: Glucose and thyroid outcomes are consistent with clinical observations; effects on lipids, calcium, phosphorus, body composition, BMI, and waist-to-hip ratio require further validation owing to data inconsistency. New biomarkers are warranted. Further clinical studies are needed in children across age groups, GHD severities, and nutritional statuses. CI - (c) 2026 The Author(s). Pediatric Investigation published by John Wiley & Sons Australia, Ltd on behalf of Futang Research Center of Pediatric Development. FAU - Wu, Wei AU - Wu W AD - Department of Pediatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology No. 1095, Jiefang Wuhan Hubei 430030 China. FAU - Song, Ningyi AU - Song N AD - Department of Pediatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology No. 1095, Jiefang Wuhan Hubei 430030 China. FAU - Zhao, Yue AU - Zhao Y AD - Department of Pediatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology No. 1095, Jiefang Wuhan Hubei 430030 China. FAU - Du, Caiqi AU - Du C AD - Department of Pediatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology No. 1095, Jiefang Wuhan Hubei 430030 China. FAU - Zhao, Yuning AU - Zhao Y AUID- ORCID: 0009-0007-2154-9624 AD - Medical Affairs Novo Nordisk (Shanghai) Pharma Trading Co., Ltd. No.8, Guangshunnan Beijing 100102 China. FAU - Wu, You AU - Wu Y AD - Medical Affairs Novo Nordisk (Shanghai) Pharma Trading Co., Ltd. No.8, Guangshunnan Beijing 100102 China. FAU - Luo, Xiaoping AU - Luo X AD - Department of Pediatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology No. 1095, Jiefang Wuhan Hubei 430030 China. LA - eng PT - Journal Article PT - Review DEP - 20260311 PL - United States TA - Pediatr Investig JT - Pediatric investigation JID - 101731527 PMC - PMC13398671 OTO - NOTNLM OT - Evidence map OT - Growth hormone deficiency OT - Metabolism OT - Systematic review COIS- Wei Wu, Ningyi Song, Yue Zhao, and Caiqi Du declare no conflict of interest. Yuning Zhao and You Wu are employees and stockholders of Novo Nordisk, but are not involved in data processing. Xiaoping Luo serves as an advisor to GenSci, Amoytop, Novo Nordisk, Takeda, Lumos, Sanofi, Medtronic, Ipsen, Visen, and Kyowa Kirin, providing research support for GenSci, Amoytop, Novo Nordisk, Takeda, Lumos, Sanofi, Medtronic, Ipsen, Visen, and Kyowa Kirin, and is a speaker for GenSci, Novo Nordisk, and Visen. Xiaoping Luo is a member of the Pediatric Investigation Editorial Board. The study design, analytical plan, and interpretation remained under the full control of the academic authors, and the outcome selection was driven by clinical relevance and protocol pre-specification. EDAT- 2026/07/25 06:36 MHDA- 2026/07/25 06:37 PMCR- 2026/03/11 CRDT- 2026/07/25 04:58 PHST- 2025/07/08 00:00 [received] PHST- 2026/02/05 00:00 [accepted] PHST- 2026/07/25 06:37 [medline] PHST- 2026/07/25 06:36 [pubmed] PHST- 2026/07/25 04:58 [entrez] PHST- 2026/03/11 00:00 [pmc-release] AID - PED470050 [pii] AID - 10.1002/ped4.70050 [doi] PST - epublish SO - Pediatr Investig. 2026 Mar 11;10(4):359-373. doi: 10.1002/ped4.70050. eCollection 2026 Aug. PMID- 42499215 OWN - NLM STAT- Publisher LR - 20260725 IS - 1544-0591 (Electronic) IS - 0022-0345 (Linking) DP - 2026 Jul 24 TI - Salivary Dipeptides and Microbiota Multiomics Biomarkers of Caries. PG - 220345261466143 LID - 10.1177/00220345261466143 [doi] AB - Dental caries is a prevalent disease shaped by dietary and metabolic interactions between the host and oral microbiota. While separate microbiome and metabolome profiling have improved the understanding of caries etiology, integrated multiomics approaches remain underutilized. We aimed to identify salivary biomarkers of caries experience in a cross-sectional study combining microbiome, metabolome, sugarome, and diet, oral, and demographic information in 217 healthy Swedish adolescents and young adults. Participants underwent clinical examination, dietary assessment, and saliva analysis using full-length 16S rRNA gene sequencing, untargeted liquid chromatography-mass spectrometry (LC-MS) metabolomics, and 2-dimensional gas chromatography-MS (GCxGC-MS)-based sugar profiling. Caries signs and restorations were summarized as decayed and filled surfaces including enamel caries. Associations between caries experience, demographics, and omics measures were evaluated using a nested cross-validated linear-regression framework with inner-loop feature selection and outer-loop performance assessment, emphasizing effect-direction stability and reproducibility across cross-validation models. Selected OMICs features were then integrated using orthogonal partial least-squares (OPLS) modeling. Three salivary dipeptides (Ser-Pro, Phe-His, and Thr-Gly) showed robust inverse associations with caries experience. Several cariogenic taxa, including Streptococcus mutans, Streptococcus sobrinus, Lactobacillus gasseri, and selected Actinomyces and Prevotella species, were positively associated with caries experience, whereas Veillonella rogosae, Stomatobaculum sp. HMT-097, and other taxa as well as 5 bacteria-predicted enzymes were associated with lower caries experience. Dietary variables and salivary sugars showed no consistent associations with caries experience. An integrated OPLS model incorporating demographics, microbiota composition, microbial-predicted enzymes, and metabolomics explained 41% of the variation in caries (R(2) = 0.41) with a cross-validated predictive ability of 30% (Q(2) = 0.30). This saliva-based multiomics framework revealed coherent microbial and metabolic signatures of caries experience. The Ser-Pro dipeptide showed the strongest inverse association and warrants validation in longitudinal cohorts to establish temporal precedence and clinical utility as a novel caries biomarker. FAU - Haworth, S AU - Haworth S AUID- ORCID: 0000-0001-7793-7326 AD - Department of Odontology, University of Umea, Umea, Sweden. AD - Bristol Dental School, University of Bristol, Bristol, UK. FAU - Esberg, A AU - Esberg A AUID- ORCID: 0000-0002-4430-8125 AD - Department of Odontology, University of Umea, Umea, Sweden. FAU - Eriksson, L AU - Eriksson L AD - Department of Odontology, University of Umea, Umea, Sweden. FAU - Ahmed, H AU - Ahmed H AD - Department of Life Technologies, Food Sciences Unit, University of Turku, Turku, Finland. FAU - Mack, C I AU - Mack CI AD - Max Rubner-Institute, Department of Safety and Quality of Fruit and Vegetables, Karlsruhe, Germany. FAU - Noerman, S AU - Noerman S AD - Clinical Nutrition Research Centre (CNRC), Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), Singapore. AD - Department of Life Sciences, Division of Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden. FAU - Nordin, E AU - Nordin E AD - Department of Life Sciences, Division of Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden. FAU - Egert, B AU - Egert B AD - Max Rubner-Institute, Department of Safety and Quality of Fruit and Vegetables, Karlsruhe, Germany. FAU - Hanhineva, K AU - Hanhineva K AD - Department of Life Technologies, Food Sciences Unit, University of Turku, Turku, Finland. FAU - Landberg, R AU - Landberg R AD - Department of Life Sciences, Division of Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden. FAU - Brunius, C AU - Brunius C AD - Clinical Nutrition Research Centre (CNRC), Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), Singapore. FAU - Johansson, I AU - Johansson I AD - Department of Odontology, University of Umea, Umea, Sweden. LA - eng PT - Journal Article DEP - 20260724 PL - United States TA - J Dent Res JT - Journal of dental research JID - 0354343 SB - IM OTO - NOTNLM OT - dental caries OT - metabolomics OT - microbiome OT - omics OT - saliva OT - sugars EDAT- 2026/07/25 06:36 MHDA- 2026/07/25 06:36 CRDT- 2026/07/25 01:53 PHST- 2026/07/25 06:36 [medline] PHST- 2026/07/25 06:36 [pubmed] PHST- 2026/07/25 01:53 [entrez] AID - 10.1177/00220345261466143 [doi] PST - aheadofprint SO - J Dent Res. 2026 Jul 24:220345261466143. doi: 10.1177/00220345261466143. PMID- 42494750 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260724 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 7 DP - 2026 Jul TI - The Effect of Screen Exposure and Early Language Stimulation on Language and Social Development of Children. PG - e113133 LID - 10.7759/cureus.113133 [doi] LID - e113133 AB - Introduction Excessive screen exposure during infancy and early childhood is linked to delayed language and social milestones. Prospective observational data regarding how natural, self-selected variations in screen reduction and caregiver-led language stimulation impact real-world milestones development remain limited. Aims and objectives The aim of this study is to prospectively evaluate the association between changes in screen exposure and caregiver language stimulation on language and social development in nine- to 18-month-old children who were initially exposed to excessive screen time. Methodology In this prospective cohort study, 72 children aged 9-18 months with a baseline screen exposure of more than two hours/day were followed up in a tertiary care hospital. During the six-month follow-up, we did not implement interventions or prescribe treatments but rather observed families and stratified them into two exposure cohorts based on validated monthly lifestyle diaries: Cohort A (spontaneous screen reduction to less than one hour/day plus natural early language stimulation by "serve-and-return" interactions, n=36): and Cohort B (spontaneous screen reduction only without structured language stimulation routines, n=36). Development was assessed using the Language Evaluation Scale Trivandrum (LEST) and Home Screen Questionnaire (HSQ) at baseline and at six months. We used multivariable linear regression to adjust for baseline confounders, including parental education and household socioeconomic status. Results At six-month follow-up, Cohort A infants had a significantly greater mean increase in overall LEST+HSQ scores than Cohort B (+16.3 vs. +7.4, p<0.001). After controlling for baseline demographics, Cohort A had significantly higher language scores in the independent domain (30.2+/-3.4 vs. 24.8+/-3.9, p<0.001) and social communication scores (28.2+/-3.1 vs. 24.4+/-3.5, p<0.001) than Cohort B. Conclusions Combining natural caregiver interaction with structured language stimulation and reduced screen time is much more associated with better language and social development outcomes than reducing screen time alone. Clinicians should emphasize the promotion of increased caregiver interaction during early childhood along with screen time restriction rather than screen restriction alone. CI - Copyright (c) 2026, Vijayakumar et al. FAU - Vijayakumar, Vimalraj AU - Vijayakumar V AD - Department of Pediatrics, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, IND. FAU - T, Arunkumar AU - T A AD - Department of Pediatrics, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, IND. FAU - R, Karthick Prasaad AU - R KP AD - Department of Pediatrics, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, IND. FAU - Rangaraj, Suresh AU - Rangaraj S AD - Department of Pediatrics, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, IND. FAU - K, Sridharini AU - K S AD - Department of Pediatrics, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, IND. FAU - G, Hariharan AU - G H AD - Department of Pediatrics, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, IND. LA - eng PT - Journal Article DEP - 20260721 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13394589 OTO - NOTNLM OT - early language stimulation OT - language development OT - pediatric screen time OT - screen exposure OT - social development COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Ethics Committee - SRM Medical College Hospital issued approval SRMIEC-ST1225-6001. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/07/24 06:35 MHDA- 2026/07/24 06:36 PMCR- 2026/07/21 CRDT- 2026/07/24 04:58 PHST- 2026/07/21 00:00 [accepted] PHST- 2026/07/24 06:36 [medline] PHST- 2026/07/24 06:35 [pubmed] PHST- 2026/07/24 04:58 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - 10.7759/cureus.113133 [doi] PST - epublish SO - Cureus. 2026 Jul 21;18(7):e113133. doi: 10.7759/cureus.113133. eCollection 2026 Jul. PMID- 42493851 OWN - NLM STAT- MEDLINE DCOM- 20260928 LR - 20260930 IS - 1440-1754 (Electronic) IS - 1034-4810 (Print) IS - 1034-4810 (Linking) VI - 62 IP - 9 DP - 2026 Sep TI - Investigating the Relationship Between Sensory Processing, Pain and Toe Walking Gait: A Survey Study. PG - 1682-1692 LID - 10.1111/jpc.70504 [doi] AB - AIM: This study aimed to examine sensory processing patterns, the frequency and impact of parent-reported pain in children who toe walk across a range of diagnoses using validated caregiver-report tools. METHODS: An online cross-sectional survey was distributed internationally between July 2024 and March 2025. Parents of children who toe walk aged 3-14 years, regardless of diagnosis, completed the Short Sensory Profile (SSP) and the Child Activity Limitations Interview-9 (CALI-9). RESULTS: The survey collected responses from 176 parents of 187 children with toe walking gait. Sensory processing challenges were frequently reported, particularly in children with autism spectrum disorder (98%). Nearly half (48% of 187) of children were reported to experience pain, most frequently in the feet/ankles, lower legs, and hips/thighs. Most parents (94%) and their child's medical professional (81%) attributed their child's pain to toe walking. Parents of children experiencing pain described significantly greater limitations in activities such as sports (OR 3.10, p < 0.001), running (OR 3.46, p < 0.001), and social participation (OR 2.43, p < 0.001). CONCLUSION: Sensory processing differences and pain were frequently reported among children who toe walk in this sample. Routine assessment of sensory processing and pain in clinical practice may guide targeted interventions to improve participation, function, and quality of life. CI - (c) 2026 The Author(s). Journal of Paediatrics and Child Health published by John Wiley & Sons Australia, Ltd on behalf of Paediatrics and Child Health Division (The Royal Australasian College of Physicians). FAU - Donne, Jack H AU - Donne JH AUID- ORCID: 0000-0002-8364-5079 AD - School of Primary and Allied Health Care, Monash University, Melbourne, Victoria, Australia. FAU - Pacey, Verity AU - Pacey V AD - School of Health Sciences and Nursing, Macquarie University, Sydney, New South Wales, Australia. FAU - Polt, Desiree AU - Polt D AD - Parent Team Member, Junction City, Kansas, USA. FAU - Powell, Jennifer A AU - Powell JA AD - School of Medicine, The University of Queensland, Brisbane, Australia. FAU - Fahey, Michael C AU - Fahey MC AUID- ORCID: 0000-0003-0811-4785 AD - Department of Paediatrics, Monash Health, Melbourne, Victoria, Australia. AD - Department of Medicine, Monash University, Melbourne, Victoria, Australia. FAU - Williams, Cylie M AU - Williams CM AUID- ORCID: 0000-0002-0223-9141 AD - School of Primary and Allied Health Care, Monash University, Melbourne, Victoria, Australia. LA - eng PT - Journal Article DEP - 20260723 PL - Australia TA - J Paediatr Child Health JT - Journal of paediatrics and child health JID - 9005421 SB - IM MH - Humans MH - Child MH - Cross-Sectional Studies MH - Female MH - Adolescent MH - Male MH - Child, Preschool MH - *Toes MH - Surveys and Questionnaires MH - *Pain/physiopathology MH - *Gait/physiology MH - *Walking/physiology MH - Parents PMC - PMC13617236 OAB - Emerging evidence suggests that toe walking gait in children may be related to disrupted sensory processing abilities. Parents in this study frequently reported sensory processing challenges among children who toe walked, regardless of the reason for toe walking. Limited research has examined the prevalence or impact of pain in children who toe walk. In this study, almost half of the children were reported to experience pain, which was associated with limitations in activities such as sports, running, and social participation. Routine assessment of sensory processing and pain in clinical practice may guide targeted interventions aiming to improve participation, function, and quality of life. OABL- eng OTO - NOTNLM OT - paediatrics OT - pain OT - sensory processing OT - survey OT - toe walking COIS- The authors declare no conflicts of interest. EDAT- 2026/07/24 06:35 MHDA- 2026/09/28 05:33 PMCR- 2026/09/28 CRDT- 2026/07/24 00:13 PHST- 2026/06/23 00:00 [revised] PHST- 2026/03/02 00:00 [received] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/09/28 05:33 [medline] PHST- 2026/07/24 06:35 [pubmed] PHST- 2026/07/24 00:13 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - JPC70504 [pii] AID - 10.1111/jpc.70504 [doi] PST - ppublish SO - J Paediatr Child Health. 2026 Sep;62(9):1682-1692. doi: 10.1111/jpc.70504. Epub 2026 Jul 23. PMID- 42492233 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261014 IS - 1530-0315 (Electronic) IS - 0195-9131 (Linking) VI - 58 IP - 11 DP - 2026 Nov 1 TI - Resting Metabolic Rate in Collegiate Male Wrestlers: Cross-Validation and Development of Prediction Equations. PG - 2524-2534 LID - 10.1249/MSS.0000000000004071 [doi] AB - PURPOSE: The purpose of the current study was to cross-validate previously developed resting metabolic rate (RMR) prediction equations using laboratory measurements of RMR as a criterion. METHODS: National Collegiate Athletic Association Division I (n = 60) and III (n = 113) male wrestlers participated in the current study (n = 173; Age: 19.6 +/- 1.5 yrs.; Height: 176.3 +/- 6.3 cm; Weight: 76.6 +/- 10.9 kg; Body Fat: 11.4 +/- 3.0%). Indirect calorimetry was used to measure RMR and Skinfold thickness was used to estimate body fat percentage (BF%) during the preseason period under standardized dress (underwear only), fasting, and resting conditions. RESULTS: Mean measured RMR was 2102 +/- 341 kcal.d -1 . All body mass-based RMR prediction equations significantly underestimated the measured RMR, with the exception of the Jagim and Schofield equations. The Tinsley fat-free mass (FFM) equation and the Cunningham equation had the lowest constant error values when compared with measured RMR (mean bias +/- standard error: 80 +/- 20 kcal and 126 +/- 20 kcal.d -1 , respectively). Linear regression indicated the Tinsley FFM (R 2 = 0.422, root-mean-squared error (RMSE) = 279 kcals, %RMSE = 13.3%), and Cunningham FFM equations had the closest agreement to measured RMR (R 2 = 0.422, RMSE = 301 kcals, %RMSE = 14.3%), along with the Jagim equation for a body mass-based prediction equation (R 2 = 0.377, RMSE = 338 kcals, %RMSE = 16.1%). The standard error of the estimate (SEE) ranged from 260 to 272 kcal.d -1 across equations. Coefficients of determination (R 2 ) ranged from 37% to 42%. The new body mass and FFM-based equations exhibited good agreement based on the constant error (26 and -13 kcal.d -1 ), RMSE (274 and 252 kcal.d -1 ), respectively. CONCLUSIONS: The newly developed equations demonstrated mean bias <2% of measured RMR. CI - Copyright (c) 2026 by the American College of Sports Medicine. FAU - Jagim, Andrew R AU - Jagim AR AD - Health Professions, University of Wisconsin-La Crosse, La Crosse, WI. AD - Intercollegiate Athletics, Patriot Performance Laboratory, Frank Pettrone Center for Sports Performance, George Mason University, Fairfax, VA. FAU - Dobbs, Ward C AU - Dobbs WC AD - Division of Kinesiology and Health, University of Wyoming, Laramie, WY. FAU - Magee, Meghan K AU - Magee MK AD - Exercise Science and Exercise Physiology, Kent State University, Kent, OH. FAU - Fields, Jennifer B AU - Fields JB AD - Intercollegiate Athletics, Patriot Performance Laboratory, Frank Pettrone Center for Sports Performance, George Mason University, Fairfax, VA. AD - Nutritional Sciences, University of Connecticut, Storrs, CT. FAU - Sims, Jesse N L AU - Sims JNL AD - Exercise Science and Exercise Physiology, Kent State University, Kent, OH. FAU - Saine, Noelle D AU - Saine ND AD - Intercollegiate Athletics, Patriot Performance Laboratory, Frank Pettrone Center for Sports Performance, George Mason University, Fairfax, VA. AD - Sport, Recreation, and Tourism Management, George Mason University, Manassas, VA. FAU - Jones, Margaret T AU - Jones MT AD - Intercollegiate Athletics, Patriot Performance Laboratory, Frank Pettrone Center for Sports Performance, George Mason University, Fairfax, VA. AD - Sport, Recreation, and Tourism Management, George Mason University, Manassas, VA. LA - eng PT - Journal Article PT - Validation Study DEP - 20260703 PL - United States TA - Med Sci Sports Exerc JT - Medicine and science in sports and exercise JID - 8005433 SB - IM MH - Humans MH - *Basal Metabolism/physiology MH - *Wrestling/physiology MH - Male MH - Calorimetry, Indirect MH - Young Adult MH - Skinfold Thickness MH - Body Composition MH - Prediction Methods, Machine MH - Adolescent MH - Body Mass Index OTO - NOTNLM OT - BODY COMPOSITION OT - ENERGY REQUIREMENTS OT - METABOLISM OT - WEIGHT MANAGEMENT OT - WRESTLING EDAT- 2026/07/24 00:37 MHDA- 2026/10/14 05:33 CRDT- 2026/07/23 18:03 PHST- 2026/10/14 05:33 [medline] PHST- 2026/07/24 00:37 [pubmed] PHST- 2026/07/23 18:03 [entrez] AID - 00005768-990000000-01108 [pii] AID - 10.1249/MSS.0000000000004071 [doi] PST - ppublish SO - Med Sci Sports Exerc. 2026 Nov 1;58(11):2524-2534. doi: 10.1249/MSS.0000000000004071. Epub 2026 Jul 3. PMID- 42491911 OWN - NLM STAT- MEDLINE DCOM- 20260723 LR - 20260813 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Associations between echocardiographic parameters and aerobic performance in young athletes. PG - e21263 LID - 10.7717/peerj.21263 [doi] LID - e21263 AB - BACKGROUND AND OBJECTIVES: Cardiac morphology can be shaped according to chronic and acute exercise and provides important findings regarding cardiac response to different types of performance. However, cardiac remodelling is a multidimensional process involving intertwined structural, functional, and haemodynamic components, making it difficult to explain with a single criterion and requiring a comprehensive assessment. The aim of this study is to investigate the effects of echocardiographic (ECHO) parameters on 30-15 interval fitness test (IFT) performance. MATERIALS AND METHODS: Twenty-three active athletes participated in the study. All ECHO measurements were performed by a specialist cardiologist using standard clinical methods, and the IFT was administered to participants after the measurements. In the analysis, ECHO variables representing the structural characteristics of the left ventricle, systolic-diastolic function, and aortic/atrial measurements were evaluated, with priority given to parameters indexed according to body surface area (BSA). Relationships between IFT performance and ECHO parameters were examined by establishing parsimonious linear regression models appropriate for small sample sizes; models were evaluated using Akaike Information Criterion (AICc)-based model comparison and model averaging, results were checked for robustness using leave-one-out cross-validation (LOOCV), and the SHapley Additive exPlanations (SHAP) approach, consistent with the model, was used for interpretability. RESULTS: In the AICc-based model comparison, the parsimonious model with the highest support consisted of the body composition (BMI) + posterior wall (PW)_I + aortic strain (AORT_STR) components and explained approximately 46% of the variance in IFT performance (mean adj. R (2) = 0.461; LOOCV root mean squared error (RMSE) = 1.811; mean DeltaAICc = 0; mean Akaike weight = 0.0476). Variable importance analyses in the best model set revealed that the variables most consistently associated with IFT were BMI (Sigmaw = 0.46; weighted mean-SHAP- = 0.154; beta = - 0.068) and posterior wall thickness indexed by BSA (PW_I) (Sigmaw = 0.35; weighted mean-SHAP- = 0.211; beta = 0.348). This was followed by IVS_I (Sigmaw = 0.191; weighted mean-SHAP- = 0.072; beta = 0.124), A wave (Sigmaw = 0.177; weighted mean-SHAP- = 0.080; beta = 0.849) and AORT_STR (Sigmaw = 0.166; weighted mean-SHAP- = 0.077; beta = 0.013) followed. Overall, the distribution of model weights across multiple models indicated significant model uncertainty, while BMI and indexed structural measures provided the strongest and most consistent signal in relation to IFT. CONCLUSIONS: In this context, it has been concluded that body composition is also a determining factor in the relationship between cardiac morphology and IFT performance. Large prospective studies are important for determining this complex relationship. CI - (c)2026 Akgumus et al. FAU - Akgumus, Alkame AU - Akgumus A AD - Department of Cardiology, Medical Faculty, Bandirma Onyedi Eylul University, Balikesir, Turkey. FAU - Kurtoglu, Ahmet AU - Kurtoglu A AD - Department of Coaching Education, Faculty of Sport Science, Bandirma Onyedi Eylul University, Balikesir, Turkey. FAU - Ozer, Omer AU - Ozer O AD - Department of Physical Education and Sport Teaching, Faculty of Sport Science, Bandirma Onyedi Eylul University, Balikesir, Turkey. FAU - Duygu, Ali AU - Duygu A AD - Department of Cardiology, Medical Faculty, Bandirma Onyedi Eylul University, Balikesir, Turkey. FAU - Car, Bekir AU - Car B AD - Department of Physical Education and Sport Teaching, Faculty of Sport Science, Bandirma Onyedi Eylul University, Balikesir, Turkey. FAU - Kurtoglu, Ertugrul AU - Kurtoglu E AD - Department of Cardiology, Medical Faculty, Malatya Turgut Ozal University, Malatya, Turkey. FAU - Uzgur, Kamil AU - Uzgur K AD - Department of Coaching Education, Faculty of Sport Science, Bandirma Onyedi Eylul University, Balikesir, Turkey. FAU - Er, Fahri AU - Er F AD - Department of Cardiology, Medical Faculty, Bandirma Onyedi Eylul University, Balikesir, Turkey. FAU - Muracki, Jaroslaw AU - Muracki J AD - Institute of Physical Culture Sciences, Department of Physical Culture and Health, University of Szczecin, Szczecin, Poland. FAU - Elkholi, Safaa M AU - Elkholi SM AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260714 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - *Echocardiography MH - Male MH - *Athletes MH - Young Adult MH - Female MH - *Exercise/physiology MH - Adolescent MH - Ventricular Function, Left/physiology MH - Exercise Test MH - Heart Ventricles/diagnostic imaging MH - *Athletic Performance/physiology PMC - PMC13378464 OTO - NOTNLM OT - Aerobic performance OT - Cardiac function OT - Cardiac morphology OT - Echocardiography COIS- The authors declare there are no competing interests. EDAT- 2026/07/23 18:35 MHDA- 2026/07/23 18:36 PMCR- 2026/07/14 CRDT- 2026/07/23 16:18 PHST- 2025/10/03 00:00 [received] PHST- 2026/03/27 00:00 [accepted] PHST- 2026/07/23 18:36 [medline] PHST- 2026/07/23 18:35 [pubmed] PHST- 2026/07/23 16:18 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - 21263 [pii] AID - 10.7717/peerj.21263 [doi] PST - epublish SO - PeerJ. 2026 Jul 14;14:e21263. doi: 10.7717/peerj.21263. eCollection 2026. PMID- 42491719 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260723 LR - 20260922 IS - 2632-1297 (Electronic) IS - 2632-1297 (Linking) VI - 8 IP - 4 DP - 2026 TI - Using reference intervals to improve interpretation of youth sport-related concussion biomarkers using a research platform. PG - fcag250 LID - 10.1093/braincomms/fcag250 [doi] LID - fcag250 AB - Youth sports-related concussion (SRC) is a major health concern. Approximately 67% of Canadian youth participate in sports and recreation, and 93% of head injuries experienced in sports and recreation are concussions. SRCs are challenging to diagnose because symptoms are often subtle, which can affect the reliability of clinical diagnostic methods that are often subjective. As undiagnosed concussions can potentially lead to unfavourable neurological implications, objective diagnostic tools have the potential to improve diagnosis and inform prognosis. Recent research has highlighted the potential utility of plasma neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) for SRC diagnosis, offering a quantitative and cost-effective diagnostic method. However, a major gap in the literature is understanding whether the magnitude of change in NfL and GFAP levels post-SRC exceeds normal variation observed at the population level. This study evaluates NfL and GFAP as diagnostic SRC biomarkers by comparing preseason and post-SRC levels measured up to 28 days after injury to population-based reference intervals. Preseason (uninjured) and post-SRC plasma samples from the Surveillance in High Schools and Community Sports to Reduce Concussions and their Consequences study were quantified with Quanterix's Neurology-4-plex-B assay and compared to previously generated age-matched reference interval. A total of 658 preseason specimens (440 male [67%]; median [range] age, 15.9 [10.4-18.4] years) and 134 post-SRC specimens (72 male [54%]; median [range] age, 16.1 [11.2-18.4] years) were assessed. Median biomarker levels were higher at post-SRC than preseason for both NfL (preseason/post-SRC = 5.1/5.5 pg/ml, P = 0.0339) and GFAP (preseason/post-SRC=51.7/59.7 pg/ml, P < 0.0001). However, when compared to population controls across the same age range, 580 (88%) preseason and 119 (89%) of post-SRC measures fell within the reference interval (5th-95th percentile) for NfL and 644 (98%) preseason and 132 (99%) of post-SRC measures fell within the reference interval for GFAP. Further, the number of participants within or above the reference interval (>95th percentile) did not differ between preseason and post-SRC groups for either NfL (P > 0.9999) or GFAP (P > 0.9999). Body mass index was inversely associated with the distribution of NfL (5th-50th/50th-95th = 23.02/22.15, P = 0.0083; 5th-50th/50th-95th = 24.37/21.74, P = 0.0038) and GFAP (5th-50th/50th-95th = 23.12/22.29, P = 0.0219; 5th-50th/50th-95th = 25.03/22.27, P = 0.0025) within the reference interval, which may explain the skew of NfL and GFAP levels in the SHRed participants compared to population controls at both preseason and post-SRC. We conclude that plasma NfL and GFAP measured up to 28 days post-SRC do not meet criteria for clinical significance as stand-alone post-acute diagnostic biomarkers for adolescent SRC. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Guarantors of Brain. FAU - Achalu, Kidus AU - Achalu K AD - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. FAU - Cooper, Jennifer G AU - Cooper JG AD - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. FAU - Tabor, Jason B AU - Tabor JB AD - Faculty of Kinesiology, Sport Injury Prevention Research Centre, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Ghodsi, Mohammad AU - Ghodsi M AD - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. FAU - Huang, Johnny AU - Huang J AD - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. FAU - Josafatow-Garcia, Nik AU - Josafatow-Garcia N AD - Faculty of Kinesiology, Sport Injury Prevention Research Centre, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Penner, Linden C AU - Penner LC AD - Faculty of Kinesiology, Sport Injury Prevention Research Centre, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Stukas, Sophie AU - Stukas S AD - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. FAU - Galarneau, Jean-Michel AU - Galarneau JM AUID- ORCID: 0000-0003-3784-8753 AD - Faculty of Kinesiology, Sport Injury Prevention Research Centre, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Fraser, Douglas D AU - Fraser DD AD - Department of Pediatrics and Clinical Neurological Sciences, Western University, London, Ontario N6A 3K7, Canada. FAU - Smirl, Jonathan AU - Smirl J AD - Faculty of Kinesiology, Sport Injury Prevention Research Centre, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Yeates, Keith O AU - Yeates KO AUID- ORCID: 0000-0001-7680-2892 AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Department of Psychology, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Debert, Chantel T AU - Debert CT AD - Faculty of Kinesiology, Sport Injury Prevention Research Centre, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Emery, Carolyn A AU - Emery CA AD - Faculty of Kinesiology, Sport Injury Prevention Research Centre, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Departments of Pediatrics and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Wellington, Cheryl L AU - Wellington CL AD - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. LA - eng PT - Journal Article DEP - 20260705 PL - England TA - Brain Commun JT - Brain communications JID - 101755125 PMC - PMC13378169 OTO - NOTNLM OT - blood-based biomarkers OT - concussion OT - context of use OT - normative data COIS- Cheryl Wellington is principal investigator on unrelated operating grants from the Canadian Institutes of Health Research, Weston Brain Institutes, Cure Alzheimer Fund, US Department of Defence, and the National Institutes of Health. Keith Owen Yeates is principal investigator on a grant from the Canada Foundation for Innovation; co-investigator on grants from the Canadian Institutes of Health Research, Brain Canada Foundation, and Ontario Brain Institute; a paid research consultant for the Research Institute at Nationwide Children's Hospital, Columbus, OH, USA; receives book royalties from Guilford Press and Cambridge University Press; has received travel support and honorariums for presentations to multiple organizations; and serves on the Data Safety and Monitoring Board for the Concussion Health Improvement Program (CHIP) Trial, University of Washington. All other authors report no competing interests. EDAT- 2026/07/23 18:34 MHDA- 2026/07/23 18:35 PMCR- 2026/07/05 CRDT- 2026/07/23 16:13 PHST- 2025/05/02 00:00 [received] PHST- 2026/04/23 00:00 [revised] PHST- 2026/04/30 00:00 [accepted] PHST- 2026/07/23 18:35 [medline] PHST- 2026/07/23 18:34 [pubmed] PHST- 2026/07/23 16:13 [entrez] PHST- 2026/07/05 00:00 [pmc-release] AID - fcag250 [pii] AID - 10.1093/braincomms/fcag250 [doi] PST - epublish SO - Brain Commun. 2026 Jul 5;8(4):fcag250. doi: 10.1093/braincomms/fcag250. eCollection 2026. PMID- 42490625 OWN - NLM STAT- MEDLINE DCOM- 20260723 LR - 20260813 IS - 1549-1676 (Electronic) IS - 1549-1277 (Print) IS - 1549-1277 (Linking) VI - 23 IP - 7 DP - 2026 Jul TI - Exploring parental prenatal influences on child health: A multicohort study and data visualisation tool. PG - e1005153 LID - 10.1371/journal.pmed.1005153 [doi] LID - e1005153 AB - BACKGROUND: The Developmental Origins of Health and Disease (DOHaD) hypothesis suggests that early life environmental exposures, especially during pregnancy, can impact long-term health. Research has largely relied on correlational evidence and has focussed on maternal factors, with less attention given to paternal, postnatal, and broader social determinants. This focus could complicate efforts to determine the most effective strategies for improving population health. METHODS AND FINDINGS: Using harmonised data across four population-based longitudinal cohort studies from the UK and Norway (births between 1991 and 2008), we took a systematic approach to explore associations of parental prenatal health behaviours (smoking, alcohol, and caffeine consumption) and low socioeconomic position (SEP) with 72 child health-related outcomes (e.g., related to body size and composition, cognitive function, mental health, blood pressure, allergy, etc.) from birth up to age 11. Where possible, cohort estimates were meta-analysed, yielding a maximum sample size of 232,139. We triangulated evidence of causality using different analytical approaches, including a Mendelian randomisation-informed approach using genetic risk scores, negative controls (maternal versus paternal and during versus post-pregnancy comparisons), and dose-response analyses. This comprehensive set of analyses generated more than 594,000 effect estimates. We developed a web app, 'EPoCH Explorer' to visualise and share our results in an accessible format. We did not find strong evidence for widespread or large effects of parental health behaviours on child health and wellbeing. Only 6% of analyses had a Cohen's D value >0.2 and FDR-adjusted P < 0.05. In most analyses, the effect estimate was similar for mothers and partners, with 51% showing a larger effect for mothers and 49% for partners. Despite the lack of widespread associations, we found consistent evidence of association between maternal smoking and small for gestational age, higher childhood body mass index (BMI), depressive symptoms, and behavioural issues, while partner smoking was consistently associated with childhood BMI and social communication difficulties. Overall, we found stronger evidence of child outcomes being associated with low SEP than with health behaviours: 15% of results for low SEP had a Cohen's D value >0.2 and FDR-P < 0.05, compared to 6% for parental smoking, 3% for alcohol, and 0.4% for caffeine. Sample sizes and statistical power varied across outcomes and there was limited ethnic diversity in our study samples. CONCLUSION: Our findings suggest that wider familial socioeconomic conditions may be a more important determinant of child health than specific parental health behaviours prenatally. Interventions to improve population health may be most effective if they target wider social inequalities, rather than individual behaviours and mothers specifically. We encourage researchers to use EPoCH Explorer to prioritise associations for exploration in their own datasets, thus enabling replication and cross-context comparison to validate and extend the generalisability of our findings. CI - Copyright: (c) 2026 Sharp et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Sharp, Gemma C AU - Sharp GC AUID- ORCID: 0000-0003-2906-4035 AD - School of Psychology, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom. AD - MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom. FAU - Lawlor, Deborah A AU - Lawlor DA AUID- ORCID: 0000-0002-6793-2262 AD - MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom. AD - Population Health Science, Bristol Medical School, University of Bristol, Bristol, United Kingdom. FAU - Easey, Kayleigh E AU - Easey KE AD - MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom. AD - School of Psychological Science, University of Bristol, Bristol, United Kingdom. FAU - Kundu, Sampurna AU - Kundu S AD - School of Psychology, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom. FAU - Elhakeem, Ahmed AU - Elhakeem A AD - School of Psychology, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom. AD - MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom. AD - Population Health Science, Bristol Medical School, University of Bristol, Bristol, United Kingdom. FAU - Hone, Edward AU - Hone E AD - Research Software Engineers Group, University of Exeter, Exeter, United Kingdom. FAU - McEachan, Rosemary R C AU - McEachan RRC AUID- ORCID: 0000-0003-1302-6675 AD - Bradford Institute for Health Research, Bradford Teaching Hospitals National Health Service Foundation Trust, Bradford, United Kingdom. FAU - Magnus, Maria C AU - Magnus MC AUID- ORCID: 0000-0002-0568-3774 AD - Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway. FAU - Havdahl, Alexandra AU - Havdahl A AD - Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway. AD - PsychGen Centre for Genetic Epidemiology and Mental Health, Division of Public Health and Prevention, Norwegian Institute of Public Health, Oslo, Norway. AD - Center for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway. AD - PROMENTA Research Centre, Department of Psychology, University of Oslo, Oslo, Norway. FAU - Relton, Caroline L AU - Relton CL AD - MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom. AD - London School of Hygiene and Tropical Medicine, London, United Kingdom. LA - eng PT - Journal Article DEP - 20260723 PL - United States TA - PLoS Med JT - PLoS medicine JID - 101231360 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Child Health MH - Child MH - *Prenatal Exposure Delayed Effects/epidemiology MH - Norway/epidemiology MH - Male MH - United Kingdom/epidemiology MH - Longitudinal Studies MH - Child, Preschool MH - Developmental Origins of Health and Disease MH - Smoking/adverse effects/epidemiology MH - Infant MH - Health Behavior MH - Infant, Newborn MH - *Parents MH - Alcohol Drinking/adverse effects/epidemiology MH - Risk Factors PMC - PMC13395330 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/23 18:35 MHDA- 2026/07/23 18:36 PMCR- 2026/07/23 CRDT- 2026/07/23 15:13 PHST- 2025/08/12 00:00 [received] PHST- 2026/06/05 00:00 [accepted] PHST- 2026/07/23 18:36 [medline] PHST- 2026/07/23 18:35 [pubmed] PHST- 2026/07/23 15:13 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - PMEDICINE-D-25-02845 [pii] AID - 10.1371/journal.pmed.1005153 [doi] PST - epublish SO - PLoS Med. 2026 Jul 23;23(7):e1005153. doi: 10.1371/journal.pmed.1005153. eCollection 2026 Jul. PMID- 42490250 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20261008 IS - 1939-134X (Electronic) IS - 1040-3590 (Linking) VI - 38 IP - 10 DP - 2026 Oct TI - Psychometric validation of the Italian State Urge to Be Physically Active Questionnaire in eating disorders: Psychopathology correlates and diagnostic differences. PG - e39-e50 LID - 10.1037/pas0001495 [doi] AB - Alongside excessive physical activity, individuals with eating disorders (EDs) frequently report a heightened urge to move and physical restlessness, which may contribute to both somatic and psychological burden. The State Urge to be Physically Active Questionnaire (SUPA-Q) specifically measures this acute, state-like dimension in ED patients, but a validated Italian version is not yet available. Two hundred thirty-three inpatients (93.6% female; M(age) = 31.7 +/- 14.3) formally diagnosed with EDs completed the SUPAQ-I alongside measures of compulsive exercise, exercise addiction, impulsivity, and ED psychopathology. Psychometric evaluation covered item performance, internal consistency, confirmatory factor analysis, convergent/divergent validity, sensitivity to change, and exploratory clinical cutoffs. Paired-samples t tests assessed score changes. SUPAQ-I scores demonstrated excellent reliability (alpha = .958, omega = 0.959) and good factorial validity. Scores significantly positively correlated with ED severity (drive for thinness, body dissatisfaction, overcontrol) and negatively with body mass index. Post hoc analyses revealed higher scores occurring in anorexia nervosa compared to binge-eating disorder, which decreased significantly over hospitalization, findings that are consistent with sensitivity to clinical change. High scores predominated in restrictive anorexia nervosa subtypes. Overall, findings support the psychometric adequacy of SUPAQ-I score interpretations for measuring acute movement urges in EDs. It appeared to capture an affect-driven and state-related dimension of movement urges related to, but not fully explained by, existing trait-based exercise measures and showed sensitive to clinical change. Further research is needed to refine cutoffs and examine the generalizability of these findings across populations and settings. (PsycInfo Database Record (c) 2026 APA, all rights reserved). FAU - Boltri, Margherita AU - Boltri M AUID- ORCID: 0000-0002-6742-8541 AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Experimental Laboratory for Metabolic Neurosciences Research. FAU - Gabutti, Carolina AU - Gabutti C AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Experimental Laboratory for Metabolic Neurosciences Research. FAU - Brusa, Federico AU - Brusa F AUID- ORCID: 0000-0002-5353-7296 AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Experimental Laboratory for Metabolic Neurosciences Research. FAU - Cera, Giulia AU - Cera G AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Experimental Laboratory for Metabolic Neurosciences Research. FAU - Villa, Valentina AU - Villa V AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Laboratorio di Psicologia, Ospedale San Giuseppe. FAU - Bastoni, Ilaria AU - Bastoni I AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Laboratorio di Psicologia, Ospedale San Giuseppe. FAU - Ducale, Sara AU - Ducale S AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Laboratorio di Psicologia, Ospedale San Giuseppe. FAU - Manzo, Francesca AU - Manzo F AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Unita Operativa Complessa dei Disturbi dell'Alimentazione e della Nutrizione, Ospedale San Giuseppe. FAU - Scalia, Alberto AU - Scalia A AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Unita Operativa Complessa dei Disturbi dell'Alimentazione e della Nutrizione, Ospedale San Giuseppe. FAU - Apicella, Emanuela AU - Apicella E AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Experimental Laboratory for Metabolic Neurosciences Research. FAU - Savino, Sandra AU - Savino S AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Unita Operativa Complessa dei Disturbi dell'Alimentazione e della Nutrizione, Ospedale San Giuseppe. FAU - Castelnuovo, Gianluca AU - Castelnuovo G AD - Department of Psychology, Universita Cattolica del Sacro Cuore. FAU - Mendolicchio, Leonardo AU - Mendolicchio L AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Experimental Laboratory for Metabolic Neurosciences Research. LA - eng SI - ClinicalTrials.gov/NCT06514456 GR - Italian Ministry of Health/ PT - Journal Article PT - Validation Study DEP - 20260723 PL - United States TA - Psychol Assess JT - Psychological assessment JID - 8915253 SB - IM MH - Humans MH - Female MH - Psychometrics MH - Adult MH - Reproducibility of Results MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Italy MH - Surveys and Questionnaires/standards MH - Male MH - Young Adult MH - *Anorexia Nervosa/diagnosis/psychology MH - Adolescent MH - Middle Aged MH - *Exercise/psychology MH - Compulsive Exercise/psychology MH - Impulsive Behavior EDAT- 2026/07/23 18:35 MHDA- 2026/09/21 17:47 CRDT- 2026/07/23 12:43 PHST- 2026/09/21 17:47 [medline] PHST- 2026/07/23 18:35 [pubmed] PHST- 2026/07/23 12:43 [entrez] AID - 2028-02437-001 [pii] AID - 10.1037/pas0001495 [doi] PST - ppublish SO - Psychol Assess. 2026 Oct;38(10):e39-e50. doi: 10.1037/pas0001495. Epub 2026 Jul 23. PMID- 42489856 OWN - NLM STAT- MEDLINE DCOM- 20260804 LR - 20260813 IS - 1867-0687 (Electronic) IS - 1708-8569 (Print) VI - 22 IP - 6 DP - 2026 Jun TI - BMI-for-age Z-score trajectories in early childhood: a comparison of GMM and KML and associated antenatal and postnatal factors. PG - 664-677 LID - 10.1007/s12519-026-01057-y [doi] AB - BACKGROUND: Early-life growth trajectories, especially during the first two years, are important for future health. However, in the context of rapidly rising childhood obesity, it is essential to characterize BMI-for-age Z-score (BAZ) trajectories in early childhood, compare optimal modeling approaches, and identify associated risk factors. METHODS: This prospective birth cohort study enrolled participants in Jinan, Shandong from 2019 to 2022. World Health Organization (WHO)-standardized BAZ scores were calculated for children at eight timepoints (0-24 months). Sex-specific BAZ trajectories were derived using growth mixture modeling (GMM) and k-means for longitudinal data (KML). The possible risk of being overweight (BAZ > 1) at age three years was predicted using logistic regression with five folds cross-validation, comparing model performance via the area under the curve (AUC). Associations between trajectory classification and antenatal and postnatal factors were examined. RESULTS: A total of 4629 mother-infant dyads were enrolled in this study. The KML-derived four-class trajectory model demonstrated optimal predictive performance for possible risk of being overweight at age three years, achieving an AUC of 0.749 and significantly outperforming the GMM model (AUC = 0.571). Male sex [odds ratio (OR) = 1.314; 95% confidence interval (95% CI): 1.098, 1.572], high birth weight (OR = 4.739; 95% CI: 3.594, 6.250), multiparity (OR = 1.265; 95% CI: 1.003, 1.594), and gestational hypertension (OR = 2.581; 95% CI: 1.387, 4.801) were identified as risk factors for high growth trajectory. CONCLUSIONS: The KML model was identified as the more effective approach for delineating BAZ trajectories and predicting the risk of being overweight in our study population. Furthermore, male sex, high birth weight, multiparity, and gestational hypertension were identified as key antenatal and postnatal factors associated with higher growth trajectories. CI - (c) 2026. The Author(s). FAU - Zhang, Ting AU - Zhang T AD - Clinical Research Center for Children's Health and Diseases, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China. FAU - Li, Zi-Yun AU - Li ZY AD - Clinical Research Center for Children's Health and Diseases, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China. FAU - Zhang, Zhen-Yu AU - Zhang ZY AD - School of Clinical Medicine, Shandong Second Medical University, Weifang, China. FAU - Gao, Mai AU - Gao M AD - Clinical Research Center for Children's Health and Diseases, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China. FAU - Zhang, Li AU - Zhang L AD - Clinical Research Center for Children's Health and Diseases, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China. FAU - Liu, Hui-Juan AU - Liu HJ AD - Clinical Research Center for Children's Health and Diseases, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China. FAU - Wang, Hai-Jun AU - Wang HJ AD - Department of Maternal and Child Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Li, Yan AU - Li Y AUID- ORCID: 0000-0003-2233-7061 AD - Clinical Research Center for Children's Health and Diseases, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China. liyanxj@sina.com. LA - eng GR - 32500156/National Natural Science Foundation of China/ GR - Z20243204/Shandong Province Traditional Chinese Medicine Science and Technology Project/ PT - Comparative Study PT - Journal Article DEP - 20260723 PL - Switzerland TA - World J Pediatr JT - World journal of pediatrics : WJP JID - 101278599 SB - IM MH - Humans MH - Male MH - Female MH - Prospective Studies MH - *Body Mass Index MH - Child, Preschool MH - Risk Factors MH - Infant MH - Birth Cohort MH - *Pediatric Obesity/epidemiology MH - Infant, Newborn MH - China/epidemiology PMC - PMC13433460 OTO - NOTNLM OT - BAZ trajectory OT - Children OT - Growth mixture modeling OT - K-means for longitudinal data OT - Pediatric OT - Possible risk of being overweight COIS- Declarations. Conflict of interest: No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article. Ethical approval: Ethical approval was granted by Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University (No. 2025-040). EDAT- 2026/07/23 12:37 MHDA- 2026/08/04 06:37 PMCR- 2026/07/23 CRDT- 2026/07/23 11:08 PHST- 2026/01/06 00:00 [received] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/02/24 00:00 [revised] PHST- 2026/08/04 06:37 [medline] PHST- 2026/07/23 12:37 [pubmed] PHST- 2026/07/23 11:08 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - 10.1007/s12519-026-01057-y [pii] AID - 1057 [pii] AID - 10.1007/s12519-026-01057-y [doi] PST - ppublish SO - World J Pediatr. 2026 Jun;22(6):664-677. doi: 10.1007/s12519-026-01057-y. Epub 2026 Jul 23. PMID- 42489731 OWN - NLM STAT- MEDLINE DCOM- 20260723 LR - 20260923 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 8 DP - 2026 Jul 23 TI - Psychological and lifestyle predictors of paediatric sleep disturbances: a cross-sectional study. LID - 10.1007/s00431-026-07254-1 [doi] LID - 603 AB - Sleep disturbances are frequent in childhood and have been associated with emotional vulnerability and modifiable lifestyle behaviours. The relative and combined contributions of child anxiety, parental anxiety, and unstructured daily routines to paediatric sleep disturbances remain incompletely characterized. We conducted a cross-sectional study of 306 otherwise healthy children aged 3-14 years. Parents completed validated questionnaires assessing sleep disturbances, child anxiety, parental anxiety, and daily lifestyle habits, including evening screen exposure. Multivariable linear regression, mediation, and cluster analyses were performed to identify correlates of sleep disturbances and distinct profiles. Clinically significant sleep disturbances were identified in 39.2% of participants. Higher child trait anxiety was consistently associated with greater sleep disturbance severity (all P < .001). Evening screen exposure was independently associated with higher sleep disturbance scores (P < .05). Parental trait anxiety not directly associated with sleep disturbances both directly and indirectly through child trait anxiety, which mediated approximately 30% of the association (P < .001). Cluster analysis identified three distinct profiles, including two groups with comparable sleep disturbance severity but contrasting characteristics: one marked by high emotional vulnerability and one by predominant lifestyle dysregulation. Conclusion: Sleep disturbances are strongly associated with trait anxiety and independently related to evening screen exposure, while parental anxiety appears to exert its effect both directly and, in part, indirectly through child anxiety. Similar sleep complaints may reflect different underlying emotional and lifestyle mechanisms. A multidimensional assessment integrating anxiety screening and evaluation of evening habits may improve early identification of at-risk children and support targeted preventive strategies within routine paediatric care. CI - (c) 2026. The Author(s). FAU - Suppiej, Agnese AU - Suppiej A AUID- ORCID: 0000-0001-5130-1450 AD - Paediatric Unit, University Hospital S. Anna, University of Ferrara, Ferrara, Italy. FAU - Sigolotto, Elia AU - Sigolotto E AUID- ORCID: 0009-0002-0673-856X AD - Paediatric Unit, University Hospital S. Anna, University of Ferrara, Ferrara, Italy. elia.sigolotto@edu.unife.it. FAU - Malaventura, Cristina AU - Malaventura C AUID- ORCID: 0000-0001-8517-4170 AD - Paediatric Unit, University Hospital S. Anna, University of Ferrara, Ferrara, Italy. LA - eng PT - Journal Article DEP - 20260723 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Child MH - Female MH - *Sleep Wake Disorders/psychology/etiology/epidemiology MH - Male MH - Child, Preschool MH - *Life Style MH - Adolescent MH - *Anxiety/complications/psychology MH - Surveys and Questionnaires MH - *Parents/psychology MH - Risk Factors MH - Screen Time PMC - PMC13395844 OTO - NOTNLM OT - Child anxiety OT - Parental anxiety OT - Screen exposure OT - Sleep disturbances OT - Sleep hygiene COIS- Declarations. Ethics approval: This study adhered to the principles of the Declaration of Helsinki. Because it involved a completely anonymous, online form without collection of identifying information, approval by an Institutional Ethics Committee was not required. Consent to participate: Parents or legal guardians provided verbal consent to receive the form, and subsequent participation was entirely voluntary. No personal data were collected. Consent to publish: Not applicable. Use of AI-assisted technologies: During the preparation of this work, the authors used ChatGPT (OpenAI) solely to improve language, readability, and grammatical accuracy. After using this tool, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication. Role of the funder: The funder had no role in the study design; data collection, analysis, or interpretation; manuscript preparation; or decision to submit the manuscript for publication. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/07/23 12:37 MHDA- 2026/07/23 12:38 PMCR- 2026/07/23 CRDT- 2026/07/23 11:04 PHST- 2026/02/07 00:00 [received] PHST- 2026/07/12 00:00 [accepted] PHST- 2026/05/04 00:00 [revised] PHST- 2026/07/23 12:38 [medline] PHST- 2026/07/23 12:37 [pubmed] PHST- 2026/07/23 11:04 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - 10.1007/s00431-026-07254-1 [pii] AID - 7254 [pii] AID - 10.1007/s00431-026-07254-1 [doi] PST - epublish SO - Eur J Pediatr. 2026 Jul 23;185(8):603. doi: 10.1007/s00431-026-07254-1. PMID- 42486265 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260908 IS - 1532-0480 (Electronic) IS - 1532-0464 (Linking) VI - 181 DP - 2026 Sep TI - Predicting healthy weight status from physical activity and dietary intake: A time-aware data mining pipeline. PG - 105083 LID - S1532-0464(26)00107-3 [pii] LID - 10.1016/j.jbi.2026.105083 [doi] AB - OBJECTIVE: To develop and evaluate a time-aware data mining pipeline that integrates accelerometry-based Physical Activity (PA), static dietary intake, and sociodemographic factors to predict Healthy Weight Status (HWS), and identify features with predictive importance for HWS. METHODS: We propose TimePAD, Time-Based Physical Activity and Dietary Intake data mining, a three-stage prediction pipeline that integrates time-based PA representations, static dietary intake, and sociodemographic variables to predict HWS categories. Stage 1 derives intensity-specific hourly PA sequences and learns time-of-day PA embeddings using a Transformer encoder trained with masked Self-Supervised Learning (SSL) reconstruction. Stage 2 combines the learnt PA embeddings with static dietary variables and participant characteristics derived from the Food Frequency Questionnaire (FFQ). Stage 3 trains prediction models and ranks predictors by their predictive importance for HWS. TimePAD was evaluated on a real-world dataset of 206 adolescents (10-16 years) with 7-day continuous wrist-worn accelerometer data, FFQ records, and sociodemographic attributes, using 10-fold cross-validation and comparison to an ARIMA-based feature engineering baseline. RESULTS: TimePAD achieves an accuracy of 82.90% and an F1-score of 67.92% for HWS prediction, outperforming the best baseline (ARIMA-based PA features + diet, 77.51% accuracy). Across experiments, time-of-day light PA (LPA) features were consistently ranked as important predictors. Other key features include time-of-day Moderate-to-Vigorous Activity (MVPA) and Sedentary (SED) levels, Tanner stage, total weekly sleep time, age (in months), weekly fruit intake, weekly vegetable and legume intake, and intake of sugar-sweetened beverages. DISCUSSION: TimePAD contributes a pipeline for learning from the time-of-day structure in wearable PA time series and integrating it with static dietary and contextual data for prediction and feature analysis. The findings suggest that LPA is likely to have a significant association with HWS, calling for further attention and investigation to better understand the role of LPA in overall health outcomes. This illustrates the potential benefits of TimePAD in modelling PA with dietary intake context in shaping healthy behaviours. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Yu, Xiaotong AU - Yu X AD - School of Computer Science, The University of Sydney, Sydney, NSW 2008, Australia. FAU - Kim, Joshua Y AU - Kim JY AD - School of Computer Science, The University of Sydney, Sydney, NSW 2008, Australia. FAU - Wattelez, Guillaume AU - Wattelez G AD - Institute for Societies, Languages and Education, University of New Caledonia, Noumea, 98800, New Caledonia. FAU - Galy, Olivier AU - Galy O AD - Institute for Societies, Languages and Education, University of New Caledonia, Noumea, 98800, New Caledonia. FAU - Caillaud, Corinne AU - Caillaud C AD - Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2008, Australia; Charles Perkins Centre, The University of Sydney, Sydney, NSW 2008, Australia. FAU - Yacef, Kalina AU - Yacef K AD - School of Computer Science, The University of Sydney, Sydney, NSW 2008, Australia. Electronic address: kalina.yacef@sydney.edu.au. LA - eng PT - Journal Article DEP - 20260722 PL - United States TA - J Biomed Inform JT - Journal of biomedical informatics JID - 100970413 SB - IM MH - Humans MH - *Data Mining/methods MH - *Exercise MH - Adolescent MH - Child MH - Female MH - *Body Weight MH - Male MH - Accelerometry MH - *Diet MH - Prediction Algorithms MH - Predictive Learning Models OTO - NOTNLM OT - Adolescent healthy weight status OT - Multimodal data integration OT - Physical activity OT - Time-series feature learning OT - Wearable sensor data COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/23 05:36 MHDA- 2026/08/18 23:36 CRDT- 2026/07/22 19:11 PHST- 2026/01/26 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/11 00:00 [accepted] PHST- 2026/08/18 23:36 [medline] PHST- 2026/07/23 05:36 [pubmed] PHST- 2026/07/22 19:11 [entrez] AID - S1532-0464(26)00107-3 [pii] AID - 10.1016/j.jbi.2026.105083 [doi] PST - ppublish SO - J Biomed Inform. 2026 Sep;181:105083. doi: 10.1016/j.jbi.2026.105083. Epub 2026 Jul 22. PMID- 42485298 OWN - NLM STAT- MEDLINE DCOM- 20260722 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - The relationship between fat talk and body image in Chinese female nursing students: The mediating role of self-acceptance. PG - e0351756 LID - 10.1371/journal.pone.0351756 [doi] LID - e0351756 AB - OBJECTIVE: This study examined whether self-acceptance mediates the relationship between fat talk and body image among Chinese female nursing students, a group under high appearance pressure. METHODS: A cross-sectional survey was conducted among 1,280 female nursing students from five medical universities in Henan Province, China, Participants were recruited from randomly selected classes, and questionnaires were distributed in person via QR codes.. Participants completed validated scales measuring fat talk (Fat Talk Scale), self-acceptance (Self-Acceptance Questionnaire), and body image (Body Image States Scale). Data were analyzed using correlation and mediation analysis (PROCESS macro, Model 4) with bootstrapping. RESULTS: Fat talk was positively correlated with both self-acceptance (r = 0.543, p < 0.001) and body image (r = 0.344, p < 0.001). Self-acceptance was also positively correlated with body image (r = 0.457, p < 0.001). After controlling for "relationship status, grade, only child status, and BMI,Mediation analysis revealed a significant indirect effect of fat talk on body image through self-acceptance (effect = 0.174, 95% CI [0.132, 0.222]), accounting for 57.80% of the total effect (total effect = 0.301). The direct effect remained significant (effect = 0.127, 95% CI [0.032, 0.222]).The standardized indirect effect (beta = 0.080) indicates a small-to-moderate effect size. CONCLUSION: Among Chinese female nursing students, engaging in fat talk conversations is associated with a more positive body image. Self-acceptance accounting for 57.80% of the total effect, though the standardized indirect effect (beta = 0.080) suggests a small-to-moderate effect size. This finding highlights the importance of cultural and contextual factors in shaping body discourse and suggests that fostering supportive communication environments and self-acceptance could be beneficial in this population. CI - Copyright: (c) 2026 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Wang, Fengxia AU - Wang F AUID- ORCID: 0009-0009-6173-1628 AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Wang, Yuxiao AU - Wang Y AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Wang, Yufan AU - Wang Y AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Yang, Qihao AU - Yang Q AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Qiu, Ju AU - Qiu J AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Li, Jinyan AU - Li J AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Liu, Meng AU - Liu M AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Wang, Xiaowei AU - Wang X AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Li, Li AU - Li L AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Xia, Xichao AU - Xia X AUID- ORCID: 0000-0001-7836-8110 AD - Pingdingshan University, Pingdingshan, Henan, China. LA - eng PT - Journal Article DEP - 20260722 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - Chinese people SB - IM MH - Humans MH - Female MH - *Body Image/psychology MH - *Students, Nursing/psychology MH - China MH - *Self Concept MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - Young Adult MH - Adult MH - Body Satisfaction MH - East Asian People PMC - PMC13390842 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/22 18:37 MHDA- 2026/07/22 18:38 PMCR- 2026/07/22 CRDT- 2026/07/22 13:33 PHST- 2026/01/07 00:00 [received] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/07/22 18:38 [medline] PHST- 2026/07/22 18:37 [pubmed] PHST- 2026/07/22 13:33 [entrez] PHST- 2026/07/22 00:00 [pmc-release] AID - PONE-D-25-68898 [pii] AID - 10.1371/journal.pone.0351756 [doi] PST - epublish SO - PLoS One. 2026 Jul 22;21(7):e0351756. doi: 10.1371/journal.pone.0351756. eCollection 2026. PMID- 42483876 OWN - NLM STAT- Publisher LR - 20260722 IS - 1533-4287 (Electronic) IS - 1064-8011 (Linking) DP - 2026 Jul 22 TI - Assessing Consumer-Grade BIA for Minimum Wrestling Weight Determination in Boys High School Wrestling. LID - 10.1519/JSC.0000000000005601 [doi] AB - Jagim, AR, Twohey, E, Fields, JB, Shepler, C, and Jones, MT. Assessing consumer-grade BIA for minimum wrestling weight determination in boys high school wrestling. J Strength Cond Res XX(X): 000-000, 2026-Preseason weight certification in high school wrestling requires valid assessment of body fat percentage to calculate a minimum wrestling weight (MWW). Although skinfold (SKF) thickness is the standard method, bioelectrical impedance analysis (BIA) devices are widely used in school settings. The current study evaluated differences in body fat percentage (BF%), MWW, and resultant minimum weight class (MWC) between SKF and a consumer-grade multifrequency BIA (MFBIA) device. Thirty-six high school male wrestlers completed hydration assessment, weigh-in, SKF testing via a three-site model, and MFBIA assessment during a single afternoon session. Body fat percentage, fat-free mass (FFM), MWW, and resulting MWC were calculated according to state-sanctioned weight certification protocols. Estimates of BF% were higher for SKFBF% compared with the MFBIA% (SKF: 12.9 +/- 4.5%; MFBIA: 10.9 +/- 5.5%; p < 0.001), resulting in a mean difference of -2.1 +/- 3.2% (95% CI: -3.1 to -0.9). Skinfold-derived values were lower for MWW (SKF: 62.1 +/- 8.9 kg; MFBIA: 63.8 +/- 10.3 kg; p < 0.001) and FFM (SKF: 57.3 +/- 8.6 kg; MFBIA: 59.3 +/- 9.7 kg; p < 0.001) compared with MFBIA-derived values. This resulted in a mean difference of -1.7 +/- 2.4 kg (95% CI: -2.4 to -0.9) and -2.1 (95% CI: -2.76 to -1.2) for MWW and FFM, respectively. Approximately 56% of athletes (n = 20) were assigned to different MWCs depending on the method used. Although group-level %BF and MWW values were similar, the observed individual-level discrepancies indicate that the current consumer-grade MFBIA device should not be used interchangeably with the state-sanctioned SKF method for weight certification, and that BIA devices intended for regulatory use should be validated against the mandated field method or a laboratory-based criterion measure. CI - Copyright (c) 2026 National Strength and Conditioning Association. FAU - Jagim, Andrew R AU - Jagim AR AD - Exercise and Sport Science Department, University of Wisconsin-La Crosse, La Crosse, Wisconsin. FAU - Twohey, Eric AU - Twohey E AD - Sports Medicine, Olmsted Medical Center, Rochester, Minnesota. FAU - Fields, Jennifer B AU - Fields JB AD - Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut. FAU - Shepler, Christian AU - Shepler C AD - School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin; and. FAU - Jones, Margaret T AU - Jones MT AD - Sport, Recreation, and Tourism Management, George Mason University, Fairfax, Virginia. LA - eng PT - Journal Article DEP - 20260722 PL - United States TA - J Strength Cond Res JT - Journal of strength and conditioning research JID - 9415084 SB - IM OTO - NOTNLM OT - athlete safety OT - bioelectrical impedance, wrestling, combat sports OT - body composition OT - weight certification EDAT- 2026/07/22 12:37 MHDA- 2026/07/22 12:37 CRDT- 2026/07/22 05:43 PHST- 2026/07/22 12:37 [medline] PHST- 2026/07/22 12:37 [pubmed] PHST- 2026/07/22 05:43 [entrez] AID - 00124278-990000000-01137 [pii] AID - 10.1519/JSC.0000000000005601 [doi] PST - aheadofprint SO - J Strength Cond Res. 2026 Jul 22. doi: 10.1519/JSC.0000000000005601. PMID- 42483753 OWN - NLM STAT- MEDLINE DCOM- 20260722 LR - 20260722 IS - 2040-1752 (Electronic) IS - 2040-1744 (Linking) VI - 17 DP - 2026 Jul 22 TI - Relative fat mass and myopia in adolescents: a cross-sectional study using NHANES data. PG - e33 LID - 10.1017/S204017442610066X [doi] AB - Adolescence is a peak period for myopia onset, which is closely related to environmental and lifestyle factors. Relative fat mass (RFM), a novel indicator of body fat, provides a more precise measure of adiposity. However, its relationship with myopia in adolescents remains poorly understood. To probe the connection between RFM and myopia in adolescents, this study included 8746 adolescents aged 12-19 years, utilizing data from the National Health and Nutrition Examination Survey (1999-2008). Myopia was defined as a spherical equivalent (SE) perceived family support --> self-efficacy --> physical exercise behavior" was only significant in nuclear families. CONCLUSION: This study reveals the internal mechanism and boundary conditions of the family sports environment influencing junior high school students' physical exercise behavior, and provides theoretical references and practical suggestions for families, schools and communities to jointly construct a sports support network and improve adolescents' physical exercise behavior. CI - Copyright (c) 2026 Zhang, Zhou, Wu, Ren and Fang. FAU - Zhang, Tingxiao AU - Zhang T AD - School of Physical Education, Liaoning Normal University, Dalian, China. FAU - Zhou, Wenlan AU - Zhou W AD - School of Physical Education, Liaoning Normal University, Dalian, China. FAU - Wu, Qi AU - Wu Q AD - School of Physical Education, Liaoning Normal University, Dalian, China. FAU - Ren, Wanyang AU - Ren W AD - School of Physical Education, Liaoning Normal University, Dalian, China. FAU - Fang, Yuxiang AU - Fang Y AD - School of Physical Education, Liaoning Normal University, Dalian, China. LA - eng PT - Journal Article DEP - 20260707 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13386413 OTO - NOTNLM OT - family sports environment OT - junior high school students OT - perceived family support OT - physical exercise behavior OT - self-efficacy OT - the chain mediating effect COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/22 12:37 MHDA- 2026/07/22 12:38 PMCR- 2026/07/07 CRDT- 2026/07/22 04:24 PHST- 2026/03/02 00:00 [received] PHST- 2026/06/08 00:00 [revised] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/07/22 12:38 [medline] PHST- 2026/07/22 12:37 [pubmed] PHST- 2026/07/22 04:24 [entrez] PHST- 2026/07/07 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1821116 [doi] PST - epublish SO - Front Psychol. 2026 Jul 7;17:1821116. doi: 10.3389/fpsyg.2026.1821116. eCollection 2026. PMID- 42482093 OWN - NLM STAT- MEDLINE DCOM- 20261021 LR - 20261023 IS - 1750-1172 (Electronic) IS - 1750-1172 (Linking) VI - 21 IP - 1 DP - 2026 Jul 21 TI - Eating behaviour phenotype in the MYT1L-related neurodevelopmental disorder: a deep phenotyping study using standardized questionnaires. LID - 10.1186/s13023-026-04497-x [doi] LID - 368 AB - BACKGROUND: The MYT1L-related neurodevelopmental disorder (MRND) is associated with global motor and language delay, intellectual disability, behavioural disturbances, epilepsy and frequent early-onset obesity. Eating disturbances have been reported but remain poorly characterized. A systematic characterization of the eating behaviour phenotype is essential to improve diagnosis and management. METHODS: We conducted a multicentre study including 21 French-speaking individuals with a molecularly confirmed MRND and either overweight/obesity or eating behaviour disturbances. Eating behaviours were reported by relatives using validated questionnaires widely employed in rare obesity research: the Dykens Hyperphagia Questionnaire (HQ), the Trousseau Impulsivity Questionnaire, the Children's Eating Behaviour Questionnaire (CEBQ), the Food Cravings Questionnaire-Trait-reduced (FCQ-T-r, adults only), and a Visual Analogue Scale (VAS) for hunger. When available, questionnaire results were compared with published studies using the same instruments. RESULTS: Persistent hyperphagic behaviours were identified in the majority of patients, with the HQ questionnaire highlighting sustained food-seeking behaviours and pervasive food preoccupation. The mean global score was 25.9, indicating a moderate yet sustained hyperphagic profile. CEBQ revealed a strong attraction to food combined with reduced satiety responsiveness and rapid eating. Hunger was reported as persistent throughout the day. In children food impulsivity was less frequent (5/14; 36%) and no correlation was found between impulsivity and hyperphagia severity, contrasting with findings in other obesity syndromes. Among adults, 62.5% had scores suggestive of food addiction (FCQ-T-r >/= 50). CONCLUSION: This study delineates an eating behaviour profile in a symptom-enriched subgroup of individuals with MRND, characterized by moderate but sustained hyperphagia, persistent hunger, impaired satiety, low food-related impulsivity in children but frequent food craving/addiction in adults. These findings support early, age-adapted and multidisciplinary management strategies and highlight the need for targeted interventions to reduce the burden on affected individuals and families. CI - (c) 2026. The Author(s). FAU - Coursimault, Juliette AU - Coursimault J AD - Department of Genetics and Reference Center for Developmental Disorders, Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Rouen, F-76000, France. j.coursimault@chu-rouen.fr. FAU - Guillon, Emilie AU - Guillon E AD - Nutrition Department, Reference Center for Rare Diseases PRADORT, Assistance Publique Hopitaux de Paris, Pitie-Salpetriere Hospital, Paris, France. AD - Sorbonne Universite, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmique Research Group, Paris, France. FAU - Lecoquierre, Francois AU - Lecoquierre F AD - Department of Genetics and Reference Center for Developmental Disorders, Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Rouen, F-76000, France. FAU - Charbonnier, Camille AU - Charbonnier C AD - Department of Genetics and Reference Center for Developmental Disorders, Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Rouen, F-76000, France. FAU - Guerrot, Anne-Marie AU - Guerrot AM AD - Department of Genetics and Reference Center for Developmental Disorders, Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Rouen, F-76000, France. FAU - Goldenberg, Alice AU - Goldenberg A AD - Department of Genetics and Reference Center for Developmental Disorders, Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Rouen, F-76000, France. FAU - Nicolas, Gael AU - Nicolas G AD - Department of Genetics and Reference Center for Developmental Disorders, Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Rouen, F-76000, France. FAU - Schaefer, Elise AU - Schaefer E AD - Service de Genetique Medicale, Institut de Genetique Medicale d'Alsace (IGMA), Hopitaux Universitaires de Strasbourg, Strasbourg, France. FAU - Ayrolles, Anael AU - Ayrolles A AD - Department of Child and Adolescent Psychiatry, APHP.Nord, Robert Debre University Hospital, Paris Cite University, Paris, France. FAU - Delorme, Richard AU - Delorme R AD - Department of Child and Adolescent Psychiatry, APHP.Nord, Robert Debre University Hospital, Paris Cite University, Paris, France. FAU - Riccardi, Florence AU - Riccardi F AD - Genetique Medicale, Centre Hospitalier Intercommunal Toulon - La Seyne- sur-Mer, Toulon, France. FAU - Grelet, Maude AU - Grelet M AD - Genetique Medicale, Centre Hospitalier Intercommunal Toulon - La Seyne- sur-Mer, Toulon, France. FAU - Caumes, Roseline AU - Caumes R AD - Universite de Lille, CHU de Lille, Clinique de Genetique <>, EA7364 RADEMEF-59000, Lille, France. FAU - Nizon, Mathilde AU - Nizon M AD - Service de Genetique Medicale, CHU Nantes, Nantes, France. FAU - Isidor, Bertrand AU - Isidor B AD - Service de Genetique Medicale, CHU Nantes, Nantes, France. FAU - Jouret, Guillaume AU - Jouret G AD - National Center of Genetics (NCG), Laboratoire National de Sante (LNS), Dudelange, L- 3555, Luxembourg. FAU - Rooryck, Caroline AU - Rooryck C AD - Univ. Bordeaux, MRGM INSERM U1211, CHU de Bordeaux, Service de Genetique Medicale, Bordeaux, F-33000, France. FAU - Amiel, Jeanne AU - Amiel J AD - Service de Medecine Genomique des Maladies Rares, Hopital Necker- Enfants Malades, AP-HP, Paris, France. FAU - Alaix, Anne-Sophie AU - Alaix AS AD - Service de Medecine Genomique des Maladies Rares, Hopital Necker- Enfants Malades, AP-HP, Paris, France. FAU - Morel, Victor AU - Morel V AD - Department of Medical Genetics, La Timone Hospital, AP-HM, La Timone Children's Hospital, Marseille, France. FAU - Jacquinet, Adeline AU - Jacquinet A AD - Department of Genetics, Sart Tilman University Hospital, Liege, Belgium. FAU - Mignot, Cyril AU - Mignot C AD - Departement de Genetique, Groupe Hospitalier Pitie-Salpetriere-Hopital Trousseau Centre de Reference Deficiences Intellectuelles de Causes Rares, APHP.Sorbonne Universite, Paris, France. FAU - Faivre, Laurence AU - Faivre L AD - Universite Bourgogne Europe, CHU Dijon Bourgogne, Inserm, CTM UMR1231, equipe GAD, FHU TRANSLAD, Centre de genetique, Centre de reference Anomalies du Developpement et Syndromes Malformatifs, Centre de reference Deficiences Intellectuelles de Causes Rares, et Centre de reference GenoPsy, Dijon, 21000, France. FAU - Fraile-Caietta, Emilie AU - Fraile-Caietta E AD - Service de pediatrie, Centre Hospitalier de Toulon, Toulon, France. FAU - Chalopin, Sarah AU - Chalopin S AD - Nutrition Department, Reference Center for Rare Diseases PRADORT, Assistance Publique Hopitaux de Paris, Pitie-Salpetriere Hospital, Paris, France. AD - Sorbonne Universite, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmique Research Group, Paris, France. FAU - Dubern, Beatrice AU - Dubern B AD - Sorbonne Universite, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmique Research Group, Paris, France. AD - Nutrition and Gastroenterology Department, Reference Center for Rare Diseases PRADORT, Assistance Publique Hopitaux de Paris, Trousseau Hospital, Paris, France. FAU - Poitou, Christine AU - Poitou C AD - Nutrition Department, Reference Center for Rare Diseases PRADORT, Assistance Publique Hopitaux de Paris, Pitie-Salpetriere Hospital, Paris, France. AD - Sorbonne Universite, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmique Research Group, Paris, France. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260721 PL - England TA - Orphanet J Rare Dis JT - Orphanet journal of rare diseases JID - 101266602 SB - IM MH - Humans MH - Female MH - Surveys and Questionnaires MH - *Feeding Behavior/physiology MH - *Neurodevelopmental Disorders/genetics/physiopathology/metabolism MH - Child MH - Male MH - Phenotype MH - Adult MH - Hyperphagia/genetics MH - Child, Preschool MH - Adolescent MH - Obesity/genetics MH - Feeding and Eating Disorders/genetics MH - Young Adult PMC - PMC13685170 OTO - NOTNLM OT - MYT1L haploinsufficiency OT - 2p25.3 deletion OT - Deep phenotypic characterization OT - Dykens OT - Eating behaviours OT - Rare disease OT - Standardized questionnaires OT - Syndromic obesity COIS- Declarations. Ethics approval and consent to participate: All patients gave their consent to participate in the study. This study expands on the 2022 cohort published by Coursimault et al., approved by the Institutional Review Board of the Rouen University Hospital (CERDE, Comite d'Ethique pour la Recherche sur Donnees Existantes et Hors Loi Jarde, Rouen, France) (notification n degrees 69-2020). Some patients were included as part of the French Rare Obesity Cohorts With Food Behavioural Disorders: Better Diagnosis for Better Treatment (ObeRare) cohort (NCT04604626). Consent for publication: Not applicable. Competing interests: JC has nothing to disclose. All other collaborators do not have anything to disclose. BD has nothing to disclose. Rhythm Pharmaceuticals provided financial support for data entry in the ObeRar database but had no role in the scientific aspects of the study, including data analysis, results, or their interpretation. EDAT- 2026/07/22 12:37 MHDA- 2026/10/21 05:32 PMCR- 2026/07/21 CRDT- 2026/07/21 23:50 PHST- 2026/10/21 05:32 [medline] PHST- 2026/07/22 12:37 [pubmed] PHST- 2026/07/21 23:50 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - 10.1186/s13023-026-04497-x [pii] AID - 4497 [pii] AID - 10.1186/s13023-026-04497-x [doi] PST - epublish SO - Orphanet J Rare Dis. 2026 Jul 21;21(1):368. doi: 10.1186/s13023-026-04497-x. PMID- 42481992 OWN - NLM STAT- MEDLINE DCOM- 20261020 LR - 20261022 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 21 TI - Targeting childhood malaria: insights from multi-country DHS data in Sub-Saharan Africa. LID - 10.1186/s12887-026-07245-z [doi] LID - 1021 AB - BACKGROUND: Malaria remains a major public health challenge in sub-Saharan Africa, disproportionately affecting children under five and pregnant women. Understanding the socio-demographic and maternal determinants of malaria across multiple countries is critical for designing targeted interventions such as Targeted Drug Administration (TDA), Perennial Malaria Chemoprevention (PMC), Seasonal Malaria Chemoprevention (SMC), Vector Control and Epidemiological Mapping. This study aimed to assess the prevalence and determinants of malaria infection among children under five across seven sub-Saharan African countries and to identify country-specific risk factors. METHODS: A cross-sectional analytical study used secondary data from the most recent Demographic and Health Surveys (DHS-8) for Burkina Faso, Cote d'Ivoire, Kenya, Mozambique, Senegal, Tanzania, and for Cameroon, Malaria Indicator Surveys (MIS-8) was used. Two outcome measures were defined: malaria infection based on rapid diagnostic test (RDT) results (five countries: Burkina Faso, Cote d'Ivoire, Mozambique, Tanzania and Cameroon) and maternal self-report (seven countries: Burkina Faso, Cote d'Ivoire, Kenya, Mozambique, Senegal, Tanzania and Cameroon). The data were analyzed using Stata/SE 17.0 and the analytic samples included 20,323 mother-child pairs for RDT analysis and 12,457 for self-reported analysis. The study examined socio-demographic and maternal characteristics, including residence, wealth index, education, parity, body mass index (BMI), and pregnancy status. Analyses incorporated sampling weights and survey design. Descriptive statistics, chi-square tests, and country-specific multivariable logistic regression models were used to identify independent predictors. RESULTS: Malaria prevalence was higher by self-report (33.5%) than by RDT diagnosis (25.2%), with consistently higher self-reported estimates across Tanzania (31.7% vs. 6.9%), Burkina Faso (58.3% vs. 27.4%), and Cote d'Ivoire (47.1% vs. 36.9%). RDT-confirmed malaria showed stronger and more consistent associations with key risk factors, including rural residence (in Burkina Faso aOR = 3.58, in Cote d'Ivoire aOR = 3.64, in Mozambique aOR = 5.74, in Tanzania aOR = 12.70; all p < 0.001), wealth status has lower malaria risk (richest quintile: Burkina Faso aOR = 0.43, Cote d'Ivoire aOR = 0.26, Mozambique aOR = 0.14, Tanzania aOR = 0.27), and while pregnancy status has significant risk (in Burkina Faso p = 0.008, in Cote d'Ivoire p = 0.005, in Cameroon p = 0.006, and in Mozambique p < 0.001), compared with weaker and sometimes inconsistent self-reported associations. The RDT- malaria diagnosis produced more plausible and statistically robust associations (in Mozambique age 25-34: aOR = 1.32, p = 0.040; in Burkina Faso parity two births: aOR = 1.33, p < 0.001), whereas self-reported malaria showed weaker or contradictory effects suggesting potential misclassification and reporting bias in self-reported diagnosis. CONCLUSION: This study demonstrates that important methodological and epidemiological differences exist between self-reported malaria and malaria RDT diagnosis across sub-Saharan African countries. Self-reported malaria showed overestimated malaria prevalence and produced weaker and less consistent associations with established risk factors, indicating limited reliability for identifying true malaria infection patterns. In contrast, malaria RDT diagnosis generated more coherent and epidemiologically plausible associations with rural residence, socioeconomic status, nutritional status, and pregnancy, reflecting more accurately the biological and environmental determinants of malaria transmission. CI - (c) 2026. The Author(s). FAU - Konja, Benjamin Akwasi AU - Konja BA AD - Biomedical and Clinical Research Centre, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana. FAU - Agyapong, Nana Ama Frimpomaa AU - Agyapong NAF AD - Department of Clinical Nutrition and Dietetics, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana. FAU - Ocran, Emmanuel Kweku AU - Ocran EK AD - Biomedical and Clinical Research Centre, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana. FAU - Anyimadu, Gloria AU - Anyimadu G AD - Biomedical and Clinical Research Centre, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana. FAU - Agyapong, Livingstone AU - Agyapong L AD - Biomedical and Clinical Research Centre, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana. FAU - Asare, Kwame Kumi AU - Asare KK AD - Biomedical and Clinical Research Centre, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana. kwame.asare@ucc.edu.gh. AD - Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana. kwame.asare@ucc.edu.gh. LA - eng PT - Journal Article DEP - 20260721 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 RN - 0 (Antimalarials) SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Infant MH - Prevalence MH - *Malaria/epidemiology/prevention & control/diagnosis MH - Child, Preschool MH - Risk Factors MH - Male MH - Africa South of the Sahara/epidemiology MH - Adult MH - Secondary Data Analysis MH - Pregnancy MH - Health Surveys MH - Antimalarials/therapeutic use MH - Young Adult PMC - PMC13681905 OTO - NOTNLM OT - Children under five OT - DHS OT - Malaria OT - Multi-country analysis OT - Socio-demographic determinants OT - Sub-Saharan Africa COIS- Declarations. Ethics approval and consent to participate: The DHS surveys obtain ethical approval from the Institutional Review Board (IRB) of ICF and relevant national ethics committees in participating countries. Informed consent is obtained from all respondents prior to participation. This study utilized publicly available, de-identified secondary data obtained from the DHS Program upon formal request and approval. As the data contain no personal identifiers, additional ethical approval was not required for this secondary analysis. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/22 12:37 MHDA- 2026/10/20 05:30 PMCR- 2026/07/21 CRDT- 2026/07/21 23:45 PHST- 2026/03/14 00:00 [received] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/10/20 05:30 [medline] PHST- 2026/07/22 12:37 [pubmed] PHST- 2026/07/21 23:45 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - 10.1186/s12887-026-07245-z [pii] AID - 7245 [pii] AID - 10.1186/s12887-026-07245-z [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 21;26(1):1021. doi: 10.1186/s12887-026-07245-z. PMID- 42477665 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261017 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jul 21 TI - Potassium intake assessed by dietary recall and urinary excretion in young South African adults: findings from the African-PREDICT study. LID - 10.1186/s12889-026-28605-5 [doi] LID - 2973 AB - BACKGROUND: South Africa has strong public health initiatives targeting salt reduction, yet population-level evidence and strategies regarding potassium intake remain limited. This gap is important given the role of potassium in mitigating sodium-related increases in blood pressure and cardiovascular disease risk. This study assessed potassium intake using dietary and urinary measures in young adults from the African-PREDICT study. METHODS: Potassium intake was estimated using three 24-hour dietary recalls and a single 24-hour urine collection per participant. Agreement between methods was evaluated using Bland-Altman analysis. RESULTS: Median potassium intake was 1911 mg/day from dietary assessment and 1683 mg/day from urinary analysis, both well below the recommended 3510 mg/day level, which is linked to sodium counterbalance and reduced cardiovascular risk. Over 90% of participants failed to meet the recommended intake across methods. Black participants and individuals of low socioeconomic status (SES) had substantially lower potassium intakes than their counterparts. Bland-Altman analysis demonstrated limited individual-level agreement (with a 95% limit-of-agreement span of approximately 5,600 mg/day), with dietary potassium intake marginally higher than urinary excretion (mean difference = 61 mg/day; p = 0.19), reflecting expected physiological potassium handling. In adjusted regression analyses, dietary potassium was inversely associated with diastolic blood pressure, while both urinary potassium and the sodium-to-potassium ratio showed no significant associations. CONCLUSION: Both methods show that potassium intake is low among young adults in South Africa, particularly among Black and low-SES groups, highlighting the need for population-level strategies to increase potassium consumption, particularly in vulnerable groups. The sodium-to-potassium ratio was associated with blood pressure only in the unadjusted model, whereas dietary potassium was associated with diastolic blood pressure in the adjusted model. Dietary assessment may be appropriate for population-level estimation of potassium intake, but its limited agreement with urinary potassium excretion at the individual level, particularly at higher intakes, may limit its utility for individual assessment. CI - (c) 2026. The Author(s). FAU - Shivambu, Arole AU - Shivambu A AD - Centre of Excellence for Nutrition, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa. shivambuarole@gmail.com. AD - Centre of Excellence for Nutrition (CEN), North-West University, 11 Hoffman Street, Potchefstroom, 2531, South Africa. shivambuarole@gmail.com. FAU - Chiromba, Antony K AU - Chiromba AK AD - Centre of Excellence for Nutrition, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa. FAU - van Zyl, Tertia AU - van Zyl T AD - Centre of Excellence for Nutrition, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa. AD - SAMRC/NWU Extramural Unit for Hypertension and Cardiovascular Disease, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa. LA - eng PT - Journal Article DEP - 20260721 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - 0 (Potassium, Dietary) SB - IM MH - Humans MH - South Africa MH - Female MH - Male MH - *Potassium, Dietary/urine/administration & dosage MH - Young Adult MH - Adult MH - *Mental Recall MH - Adolescent MH - *Diet/statistics & numerical data PMC - PMC13670738 OTO - NOTNLM OT - Blood pressure OT - Dietary potassium OT - Potassium intake OT - Urinary potassium OT - Young adults COIS- Declarations. Ethics approval and consent to participate: Ethical approval of the present study and the African-PREDICT were obtained from the North-West University Health Research Ethics Committee, reference numbers NWU-00136-22-A1 and NWU-00001-12-A1. Gatekeeper permissions were obtained from the National Department, and the North-West Provincial Department of Health. All participants provided written informed consent before data collection, and the study adhered to the updated principles of the Declaration of Helsinki. Competing interests: The authors declare no competing interests. Consent to participate: Not applicable. EDAT- 2026/07/21 00:35 MHDA- 2026/10/15 07:17 PMCR- 2026/07/21 CRDT- 2026/07/20 23:58 PHST- 2026/05/08 00:00 [received] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/10/15 07:17 [medline] PHST- 2026/07/21 00:35 [pubmed] PHST- 2026/07/20 23:58 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - 10.1186/s12889-026-28605-5 [pii] AID - 28605 [pii] AID - 10.1186/s12889-026-28605-5 [doi] PST - epublish SO - BMC Public Health. 2026 Jul 21;26(1):2973. doi: 10.1186/s12889-026-28605-5. PMID- 42475851 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260907 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 90 DP - 2026 Sep-Oct TI - Assessment of malnutrition in hospitalized children: Comparison of STAMP, PYMS and STRONG-Kids screening tools. PG - 618-626 LID - S0882-5963(26)00327-1 [pii] LID - 10.1016/j.pedn.2026.07.025 [doi] AB - AIM: Early identification of malnutrition risk in hospitalized children is essential for timely nutritional intervention. This study aims diagnostic performance of three pediatric malnutrition screening tools validated in Turkish: STAMP, PYMS, and STRONG-Kids. METHODS: In this cross-sectional study, 148 hospitalized children were included. Nutritional risk was evaluated using STAMP, PYMS, and STRONG-Kids screening tools. Anthropometric measurements were performed, and height-for-age, Body Mass Index (BMI)-for-age, and Middle Upper Arm Circumference (MUAC)-for-age z-scores were calculated. The sensitivity and specificity of each tool were assessed in identifying chronic and acute malnutrition. Receiver operating characteristic (ROC) curve analysis was used to assess the discriminative ability of the screening tools. RESULTS: Chronic malnutrition was identified in 12.8% of patients and acute malnutrition in 15.5%. STAMP and STRONG-Kids showed the highest sensitivity for detecting chronic malnutrition (84.2% and 84.3%), while PYMS had the highest specificity. STRONG-Kids demonstrated the greatest sensitivity for acute malnutrition and low MUAC z-scores (100.0%). ROC analysis showed that PYMS had the highest Area Under the Curve (AUC) for acute malnutrition, whereas STRONG-Kids had the highest AUC for chronic malnutrition, although all tools demonstrated limited discriminative ability for chronic malnutrition. CONCLUSION: STAMP and STRONG-Kids were more sensitive in detecting malnutrition risk, whereas PYMS showed higher specificity. Tool performance varied according to anthropometric indicators. IMPLICATIONS TO PRACTICE: In clinical practice, selecting the screening tool according to the targeted malnutrition type and available anthropometric indicators may improve early detection and allow more effective prioritization of nutritional interventions in hospitalized children. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Mutlu, Elif AU - Mutlu E AD - Ankara University, Graduate School of Health Sciences, Department of Nutrition and Dietetics, Ankara, Turkiye. Electronic address: elifmutlu@hacettepe.edu.tr. FAU - Kokturk, Seda Nur AU - Kokturk SN AD - Bayburt University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Bayburt, Turkiye. Electronic address: sedanurkokturk@bayburt.edu.tr. FAU - Ersoy Soke, Nursena AU - Ersoy Soke N AD - Ankara University, Graduate School of Health Sciences, Department of Nutrition and Dietetics, Ankara, Turkiye. FAU - Yardimci, Hulya AU - Yardimci H AD - Ankara University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara, Turkiye. Electronic address: yildirimh@ankara.edu.tr. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260720 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Male MH - Child, Preschool MH - *Mass Screening/methods MH - Turkey MH - *Nutrition Assessment MH - *Child, Hospitalized MH - Sensitivity and Specificity MH - Child MH - *Child Nutrition Disorders/diagnosis/epidemiology MH - Infant MH - ROC Curve MH - Risk Assessment MH - *Malnutrition/diagnosis MH - Anthropometry MH - Nutritional Status MH - Body Mass Index OTO - NOTNLM OT - Child OT - Malnutrition OT - Nutrition assessment OT - Nutritional status COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/21 00:35 MHDA- 2026/09/07 23:34 CRDT- 2026/07/20 18:03 PHST- 2026/01/07 00:00 [received] PHST- 2026/07/13 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/09/07 23:34 [medline] PHST- 2026/07/21 00:35 [pubmed] PHST- 2026/07/20 18:03 [entrez] AID - S0882-5963(26)00327-1 [pii] AID - 10.1016/j.pedn.2026.07.025 [doi] PST - ppublish SO - J Pediatr Nurs. 2026 Sep-Oct;90:618-626. doi: 10.1016/j.pedn.2026.07.025. Epub 2026 Jul 20. PMID- 42475675 OWN - NLM STAT- MEDLINE DCOM- 20260720 LR - 20260813 IS - 1438-8871 (Electronic) IS - 1439-4456 (Print) IS - 1438-8871 (Linking) VI - 28 DP - 2026 Jul 20 TI - Mobile App Use and Pregnancy Health Literacy: Cross-Sectional Study Using Bayesian Network Analysis. PG - e85403 LID - 10.2196/85403 [doi] LID - e85403 AB - BACKGROUND: Health literacy is crucial for pregnancy outcomes; yet, 15%-44% of pregnant women have low health literacy, negatively affecting maternal and fetal health. While pregnancy apps are increasingly used to support it, the psychological mechanisms through which they influence behavior remain unclear. Understanding these mechanisms is essential for designing effective interventions. Cognitive load theory (CLT) and the integrated model of cognitive-affective learning with media (ICALM) provide theoretical frameworks for understanding these digital interventions in pregnancy's emotionally intense context. OBJECTIVE: This study aimed to understand the psychological and social-cognitive pathways through which engagement with pregnancy apps may enhance health literacy and behaviors. METHODS: This cross-sectional survey study included 998 pregnant and early postpartum women aged 18-45 years from the United States and analyzed the data using Bayesian Network (BN) modeling informed by CLT and ICALM. Participants were stratified into Pregnancy+ (Royal Philips) users (n=362), other pregnancy app users (n=507), and nonapp users (n=129). We measured digital engagement, emotions, health literacy levels, support levels and sources, and health behaviors, including physical activity, nutrition, and stress management. The BN model underwent systematic refinement through bootstrap resampling (n=1000) to evaluate arc strength, followed by k-fold cross-validation (k=5) to assess model generalizability and predictive performance. RESULTS: In our study, pregnancy apps improve health literacy or behaviors, but not through direct pathways. Instead, they work through two indirect psychological pathways: (1) digital engagement related to positive emotions, which in turn is related to health literacy and stress management, and (2) digital engagement strengthened support networks, which in turn are related to health literacy. No direct pathways from digital engagement to health literacy or behaviors were retained. Pregnancy+ users demonstrated stronger adherence to these pathways compared with other app users and nonusers, by demonstrating more joyfulness (5.1 vs 4.7; P=.046), elevated support levels (4.1 vs 3.9; P=.03), and higher critical health literacy scores (8.4 vs 8.2 vs 7.7; P<.001). Pregnancy+ users also showed higher engagement frequencies (P<.001) and more frequently cited pregnancy apps as valuable information sources (78% vs 68%, P=.01) compared with users of other pregnancy apps. CONCLUSIONS: This study reveals that pregnancy apps may enhance health literacy by fostering positive emotions and strengthening support networks. This finding challenges assumptions about digital health interventions and demonstrates that apps function as psychological support systems rather than mere information sources. The findings validate CLT and ICALM within pregnancy contexts, showing that emotionally supportive apps reduce irrelevant emotional processing that consumes cognitive capacity, thereby enhancing information retention. For practice, app developers should prioritize emotional support and social connection over content volume, while health care providers should recommend apps that enhance emotional well-being. This study demonstrates BN's value for revealing complex psychological relationships in digital health contexts. CI - (c)Hanne A A Spelt, Renee A Otte, Ad J M Denissen, Shihan Wang, Erin E O'Connor, Robin Neuhaus, Lucie Duracher. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 20.07.2026. FAU - Spelt, Hanne A A AU - Spelt HAA AUID- ORCID: 0000-0002-5304-4109 AD - Research & Development, Philips Mother & Child Care and Women's Health, Eindhoven, The Netherlands. FAU - Otte, Renee A AU - Otte RA AUID- ORCID: 0000-0001-7939-6199 AD - Research & Development, Philips Mother & Child Care and Women's Health, Eindhoven, The Netherlands. FAU - Denissen, Ad J M AU - Denissen AJM AUID- ORCID: 0000-0003-4244-8850 AD - Innovation & Development and AI Solutions, Philips Data Science & AI Engineering, Eindhoven, The Netherlands. FAU - Wang, Shihan AU - Wang S AUID- ORCID: 0000-0001-5971-7522 AD - Department of Information and Computing Sciences, Utrecht University, Utrecht, The Netherlands. FAU - O'Connor, Erin E AU - O'Connor EE AUID- ORCID: 0009-0005-3361-1080 AD - Nested Institute for Families, New York, NY, United States. AD - Teaching and Learning, New York University, New York, NY, United States. FAU - Neuhaus, Robin AU - Neuhaus R AUID- ORCID: 0000-0002-6975-8712 AD - Nested Institute for Families, New York, NY, United States. AD - Teaching and Learning, New York University, New York, NY, United States. FAU - Duracher, Lucie AU - Duracher L AUID- ORCID: 0009-0001-5391-0425 AD - Research & Development, Philips Mother & Child Care and Women's Health, Eindhoven, The Netherlands. LA - eng PT - Journal Article DEP - 20260720 PL - Canada TA - J Med Internet Res JT - Journal of medical Internet research JID - 100959882 SB - IM MH - Female MH - Humans MH - Pregnancy MH - *Health Literacy MH - *Mobile Applications/statistics & numerical data MH - Cross-Sectional Studies MH - Bayes Theorem MH - Adult MH - Adolescent MH - Young Adult MH - Middle Aged MH - Digital Health PMC - PMC13434253 OTO - NOTNLM OT - Bayesian networks OT - digital lifestyle interventions OT - health literacy OT - mHealth OT - mobile apps OT - pregnancy OT - probabilistic networks OT - women's health COIS- Conflicts of Interest: HAAS, RAO, AJMD, and LD are employed by Royal Philips, which also owns Pregnancy+. EDAT- 2026/07/20 18:35 MHDA- 2026/07/20 18:36 PMCR- 2026/07/20 CRDT- 2026/07/20 16:53 PHST- 2025/10/07 00:00 [received] PHST- 2026/04/10 00:00 [accepted] PHST- 2026/07/20 18:36 [medline] PHST- 2026/07/20 18:35 [pubmed] PHST- 2026/07/20 16:53 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - v28i1e85403 [pii] AID - 10.2196/85403 [doi] PST - epublish SO - J Med Internet Res. 2026 Jul 20;28:e85403. doi: 10.2196/85403. PMID- 42474673 OWN - NLM STAT- Publisher LR - 20260720 IS - 1573-2584 (Electronic) IS - 0301-1623 (Linking) DP - 2026 Jul 20 TI - Clinical outcomes of thulium fiber laser versus holmium:YAG laser during pediatric retrograde intrarenal surgery: a multicenter cohort study. LID - 10.1007/s11255-026-05292-0 [doi] AB - OBJECTIVE: The thulium fiber laser (TFL) is a new-generation laser technology that has been increasingly used in endourology in recent years. However, data on the use of TFL in the treatment of pediatric kidney stones are limited. The aim of this study was to compare the efficacy and safety of thulium fiber laser (TFL) and Holmium: Yttrium Aluminum Garnet (Ho:YAG) laser in children undergoing retrograde intrarenal surgery (RIRS) for a solitary renal stone measuring 10-20 mm. MATERIALS AND METHODS: Pediatric patients (< 18 years) with a solitary renal stone measuring 10-20 mm who underwent RIRS at two tertiary referral centers between January 2020 and March 2026 were retrospectively reviewed. Patients were divided into two groups based on the laser technology used: Ho:YAG and TFL. Ho:YAG lithotripsy was predominantly performed using fragmentation strategy, whereas TFL was mainly used in dusting mode. The primary endpoint was the stone-free rate (SFR), as assessed by ultrasound at the third postoperative month. Secondary endpoints included operative time, fluoroscopy time, intraoperative stone retropulsion, the need for reintervention, length of hospital stay, and complications according to the Clavien-Dindo classification. RESULTS: A total of 74 patients were included in the study. Forty-eight patients were treated with Ho:YAG, and 26 with TFL. The groups were comparable in terms of age, sex, body mass index, stone size, stone density, and stone location. Operative time was significantly shorter in the TFL group than in the Ho:YAG group (64.0 +/- 28.35 vs. 80.0 +/- 30.17 min, p = 0.028). Intraoperative stone retropulsion occurred significantly less frequently in the TFL group (11.5% vs. 35.4%, p = 0.031). The 3-month stone-free rate was 92.3% in the TFL group and 85.4% in the Ho:YAG group, with no significant difference between the groups (p = 0.486). No significant differences were found between the groups in terms of fluoroscopy time, reintervention rate, and length of hospital stay. Complication rates were similar, and no Clavien-Dindo grade IV or V complications were observed in either group. CONCLUSION: These findings suggest that TFL may represent a safe and effective alternative to the Ho:YAG laser in pediatric RIRS. However, further prospective multicenter studies using standardized laser settings are warranted to validate these findings. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature B.V. FAU - Ozcift, Burak AU - Ozcift B AUID- ORCID: 0000-0001-8474-2308 AD - Department of Pediatric Urology, Health Sciences University, Izmir Dr. Behcet Uz Child Diseases and Surgery Training and Research Hospital, Ismet Kaptan Mh. Sezer Dogan Sok. No: 11 Konak, Izmir, Turkey. burakozcift@gmail.com. FAU - Micoogullari, Uygar AU - Micoogullari U AUID- ORCID: 0000-0003-4729-6104 AD - Department of Urology, Izmir Can Hospital, Izmir, Turkey. LA - eng PT - Journal Article DEP - 20260720 PL - Netherlands TA - Int Urol Nephrol JT - International urology and nephrology JID - 0262521 SB - IM OTO - NOTNLM OT - Flexible ureteroscopy OT - Holmium:YAG laser OT - Pediatric urolithiasis OT - Renal stone OT - Retrograde intrarenal surgery OT - Thulium fiber laser COIS- Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Ethics Committee of Health Sciences University Tepecik Training and Research Hospital (No. 2022/12-27). EDAT- 2026/07/20 12:40 MHDA- 2026/07/20 12:40 CRDT- 2026/07/20 11:08 PHST- 2026/06/27 00:00 [received] PHST- 2026/07/15 00:00 [accepted] PHST- 2026/07/20 12:40 [medline] PHST- 2026/07/20 12:40 [pubmed] PHST- 2026/07/20 11:08 [entrez] AID - 10.1007/s11255-026-05292-0 [pii] AID - 10.1007/s11255-026-05292-0 [doi] PST - aheadofprint SO - Int Urol Nephrol. 2026 Jul 20. doi: 10.1007/s11255-026-05292-0. PMID- 42474127 OWN - NLM STAT- MEDLINE DCOM- 20260720 LR - 20260720 IS - 1464-5033 (Electronic) IS - 0301-4460 (Linking) VI - 53 IP - 1 DP - 2026 Dec TI - The estimation model for appendicular skeletal muscle mass in US children and adolescents. PG - 2699717 LID - 10.1080/03014460.2026.2699717 [doi] AB - BACKGROUND: Adult guidelines recommend height-adjusted appendicular skeletal muscle mass (ASM) as the evaluation index for muscle mass. AIM: To develop and validate predictive equations for ASM in children and adolescents. SUBJECTS AND METHODS: A cross-sectional secondary analysis of National Health and Nutritional Examination Surveys (NHANES) data was conducted on United States children and adolescents aged 8-19 years. ASM was assessed by the sum of the lean mass of the upper and lower limbs. Multiple linear regression analyses were performed to estimate ASM using age, race and anthropometric variables [standing height (Ht), weight (Wt), arm circumference (AC) and waist circumference (WC)] with different combinations. RESULTS: Using multiple linear regression analyses, two predictive equations were generated. Equation = 0.502 + 0.388 * Wt (kg) - 0.234 * WC (cm) + 0.217 * Age (y) + 1.055 * Race (non-black = 0, black = 1) + 0.066 * Ht (cm) was for boys (adjusted R(2) 0.965 and standard error of the estimate (SEE) 1.42 kg). Equation = -2.868 + 0.261 * Wt (kg) - 0.092 * WC (cm) + 1.357 * Race (non-black = 0, black = 1) + 0.066 * Ht (cm) was for girls (adjusted R(2) 0.938 and SEE 1.18 kg). CONCLUSION: The two anthropometric prediction equations presented for ASM are simple and accurate tools for predicting ASM in US children and adolescents. FAU - Zhu, Xiaoliang AU - Zhu X AD - Department of Endocrinology, Dongfang Hospital, Beijing University of Chinese Medicine, Qinhuangdao Hospital (Qinhuangdao Hospital of Traditional Chinese Medicine), Qinhuangdao, Hebei Province, China. FAU - Zhang, Yingjie AU - Zhang Y AD - Department of Endocrinology, Dongfang Hospital, Beijing University of Chinese Medicine, Qinhuangdao Hospital (Qinhuangdao Hospital of Traditional Chinese Medicine), Qinhuangdao, Hebei Province, China. FAU - Zhou, Ying AU - Zhou Y AD - Department of Endocrinology, Dongfang Hospital, Beijing University of Chinese Medicine, Qinhuangdao Hospital (Qinhuangdao Hospital of Traditional Chinese Medicine), Qinhuangdao, Hebei Province, China. FAU - Xu, Jianghong AU - Xu J AD - Department of Endocrinology, Dongfang Hospital, Beijing University of Chinese Medicine, Qinhuangdao Hospital (Qinhuangdao Hospital of Traditional Chinese Medicine), Qinhuangdao, Hebei Province, China. FAU - Cheng, Gang AU - Cheng G AD - Department of Endocrinology, Dongfang Hospital, Beijing University of Chinese Medicine, Qinhuangdao Hospital (Qinhuangdao Hospital of Traditional Chinese Medicine), Qinhuangdao, Hebei Province, China. LA - eng PT - Journal Article DEP - 20260720 PL - England TA - Ann Hum Biol JT - Annals of human biology JID - 0404024 SB - IM MH - Humans MH - Adolescent MH - Child MH - *Muscle, Skeletal/physiology/anatomy & histology MH - Female MH - Male MH - United States MH - Cross-Sectional Studies MH - *Anthropometry/methods MH - Young Adult MH - Nutrition Surveys MH - Models, Biological OTO - NOTNLM OT - Appendicular skeletal muscle mass OT - adolescents OT - children OT - predictive equations EDAT- 2026/07/20 12:40 MHDA- 2026/07/20 12:41 CRDT- 2026/07/20 08:52 PHST- 2026/07/20 12:41 [medline] PHST- 2026/07/20 12:40 [pubmed] PHST- 2026/07/20 08:52 [entrez] AID - 10.1080/03014460.2026.2699717 [doi] PST - ppublish SO - Ann Hum Biol. 2026 Dec;53(1):2699717. doi: 10.1080/03014460.2026.2699717. Epub 2026 Jul 20. PMID- 42472792 OWN - NLM STAT- MEDLINE DCOM- 20261019 LR - 20261022 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 20 TI - Device-derived skin moisture, oil and softness scores in infants and young children with atopic dermatitis: a prospective case-control study. LID - 10.1186/s12887-026-07373-6 [doi] LID - 1017 AB - BACKGROUND: Atopic dermatitis (AD) is a chronic, inflammatory skin disease that predominantly affects infants and children. AD is associated with impaired skin barrier function, increased transepidermal water loss and reduced skin hydration. Bioelectrical impedance analysis (BIA) has been used as a non-invasive approach for estimating skin moisture-related parameters. This study aimed to investigate skin moisture percentage and additional device-derived skin surface scores (MOIST, OIL, and SOFTNESS) in children with AD and to evaluate their relationship with disease severity. METHODS: This prospective case-control study was conducted from January to March 2025 at the University of Health Sciences Umraniye Training and Research Hospital. The study included 50 children with AD and 50 control children without clinically apparent AD or visible inflammatory skin disease. All participants were aged 0-2 years, defined as children younger than 3 years. Skin moisture percentage and device-derived MOIST, OIL and SOFTNESS scores were measured using a portable bioelectrical impedance device. AD severity was assessed using the SCORing Atopic Dermatitis (SCORAD) index and grouped according to commonly used total SCORAD severity thresholds. Complete blood count parameters were recorded for both groups, whereas serum total IgE, serum specific IgE levels for hen's egg, cow's milk, and nuts, and skin prick test results were additionally recorded in the AD group. RESULTS: Children with AD had significantly lower skin moisture percentage than controls (33.15% versus 44.0%; p = 0.001). Device-derived MOIST, OIL, and SOFTNESS scores were also significantly lower in the AD group than in controls. These parameters were lower in children with severe AD than in those with mild-to-moderate AD. In the AD group, food allergen sensitization was detected in 20 patients (40%); however, in this exploratory subgroup analysis, device-derived skin parameters did not differ significantly between patients with and without allergen sensitization. CONCLUSIONS: Children with AD had lower device-derived skin moisture percentage and skin surface scores than controls without clinically apparent AD or visible inflammatory skin disease. These parameters were also lower in severe AD. Device-derived skin surface measurements may provide supportive, non-invasive information on skin surface changes in children with AD; however, further validation studies are needed before routine clinical use. CI - (c) 2026. The Author(s). FAU - Alkaya, Halil AU - Alkaya H AUID- ORCID: 0009-0007-7256-3960 AD - Department of Pediatric Allergy and Immunology, Umraniye Training and Research Hospital, Istanbul, Turkey. halilalkaya2910@gmail.com. FAU - Altas, Ugur AU - Altas U AD - Department of Pediatric Allergy and Immunology, Umraniye Training and Research Hospital, Istanbul, Turkey. FAU - Altas, Zeynep Meva AU - Altas ZM AD - Department of Public Health, Marmara University Faculty of Medicine, Istanbul, Turkey. FAU - Vazgecer, Ebru Ogultekin AU - Vazgecer EO AD - Department of Pediatrics, Umraniye Training and Research Hospital, Istanbul, Turkey. FAU - Sogutlu, Yakup AU - Sogutlu Y AD - Department of Pediatric Emergency Medicine, Umraniye Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. FAU - Ozkars, Mehmet Yasar AU - Ozkars MY AD - Department of Pediatric Allergy and Immunology, Umraniye Training and Research Hospital, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20260720 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Dermatitis, Atopic/diagnosis/physiopathology MH - Prospective Studies MH - Case-Control Studies MH - Female MH - Male MH - Infant MH - *Electric Impedance MH - Severity of Illness Index MH - Child, Preschool MH - Infant, Newborn MH - *Skin/physiopathology PMC - PMC13678910 OTO - NOTNLM OT - Atopic dermatitis OT - Bioelectrical impedance analysis OT - Children OT - Eczema OT - Infants OT - Pediatric allergy OT - Pediatric dermatology OT - Skin moisture OT - Skin surface measurement COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Umraniye Egitim ve Arastirma Hastanesi (decision number 420, dated 12/12/2024). Written informed consent was obtained from all parents/guardians of participating children before inclusion in the study. All procedures were conducted in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/20 00:37 MHDA- 2026/10/19 05:30 PMCR- 2026/07/20 CRDT- 2026/07/19 23:15 PHST- 2025/01/16 00:00 [received] PHST- 2026/07/16 00:00 [accepted] PHST- 2026/10/19 05:30 [medline] PHST- 2026/07/20 00:37 [pubmed] PHST- 2026/07/19 23:15 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - 10.1186/s12887-026-07373-6 [pii] AID - 7373 [pii] AID - 10.1186/s12887-026-07373-6 [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 20;26(1):1017. doi: 10.1186/s12887-026-07373-6. PMID- 42471634 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261017 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 18 TI - Associations of Haller index and manual depth measurement with clinical findings and pulmonary function in children with pectus excavatum: a retrospective cross-sectional study. LID - 10.1186/s12887-026-07308-1 [doi] LID - 1003 AB - BACKGROUND: Pectus excavatum (PE) is the most common congenital chest wall deformity. Its severity is usually assessed by chest computed tomography (CT) based indices such as the Haller index (HI) and correction index (CI). However, evidence supporting non-imaging anthropometric methods is limited. Manual depth measurement (MDM) is a simple, noninvasive bedside method that may offer clinical value. METHODS: This retrospective cross-sectional study included children diagnosed with pectus excavatum and followed at a tertiary center between 2017 and 2024. Demographics, pulmonary function tests (PFTs), symptoms, comorbidities, and echocardiographic data were analyzed. HI and CI were measured using chest CT scans. MDM values recorded during follow-up were retrieved from physical exam notes. RESULTS: A total of 127 patients were included, with a median age of 7.25 years (IQR, 7.05). Median HI was 2.70 (IQR, 0.56), median MDM was 2.00 cm (IQR, 1.35), and median CI was 16% (IQR, 6.7). MDM was significantly correlated with HI (p = 0.012). ROC analysis showed that MDM moderately but significantly discriminated severe deformity defined as HI> 2.5, with an optimal cut-off value of 1.75 cm. Respiratory symptoms and comorbidities were present in 39.4% and 38.6% of patients, respectively. Pulmonary function impairment was observed in 19% of patients, predominantly with a restrictive pattern. HI> 2.5 was associated with reduced forced vital capacity (FVC) and total lung capacity (TLC), whereas the association between MDM> 1.75 cm and TLC <80% weakened after adjustment for age. CONCLUSION: MDM is a practical bedside measurement that correlates with HI and involves no radiation exposure. An MDM threshold of 1.75 cm was associated with HI> 2.5 in the CT-evaluated subgroup and may support conservative follow-up when interpreted together with clinical and functional findings. This threshold should be considered exploratory and requires prospective validation. CI - (c) 2026. The Author(s). FAU - Yoruk, Begum AU - Yoruk B AUID- ORCID: 0000-0001-6599-9802 AD - Division of Pediatric Pulmonology, Faculty of Medicine, Medeniyet University, Istanbul, Turkiye. FAU - Caglar, Yasemin Mocan AU - Caglar YM AUID- ORCID: 0000-0002-9609-478X AD - Division of Pediatric Pulmonology, Faculty of Medicine, Medeniyet University, Istanbul, Turkiye. FAU - Ulgen, Ozge AU - Ulgen O AUID- ORCID: 0000-0002-9271-5446 AD - Division of Pediatric Pulmonology, Faculty of Medicine, Medeniyet University, Istanbul, Turkiye. FAU - Oksay, Sinem Can AU - Oksay SC AUID- ORCID: 0000-0001-9801-3181 AD - Division of Pediatric Pulmonology, Faculty of Medicine, Medeniyet University, Istanbul, Turkiye. FAU - Bilgin, Gulay AU - Bilgin G AUID- ORCID: 0000-0001-6207-3748 AD - Division of Pediatric Pulmonology, Faculty of Medicine, Medeniyet University, Istanbul, Turkiye. FAU - Tortop, Deniz Mavi AU - Tortop DM AUID- ORCID: 0000-0002-9134-5658 AD - Division of Pediatric Pulmonology, Faculty of Medicine, Medeniyet University, Istanbul, Turkiye. FAU - Girit, Saniye AU - Girit S AUID- ORCID: 0000-0001-7556-6568 AD - Division of Pediatric Pulmonology, Faculty of Medicine, Medeniyet University, Istanbul, Turkiye. saniye.girit@medeniyet.edu.tr. LA - eng PT - Journal Article DEP - 20260718 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Funnel Chest/physiopathology/diagnosis/diagnostic imaging MH - Cross-Sectional Studies MH - Retrospective Studies MH - Child MH - Female MH - Male MH - Respiratory Function Tests MH - Tomography, X-Ray Computed MH - Severity of Illness Index MH - Child, Preschool MH - Adolescent MH - *Anthropometry/methods PMC - PMC13670605 OTO - NOTNLM OT - anthropometric measurement OT - manual depth measurement OT - pectus excavatum OT - pediatric OT - pulmonary function test COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Ethics Committee of Kartal Kosuyolu Hospital on January 7, 2025 (Approval Number: 2025/01/1005). The study was conducted in accordance with the principles of the Declaration of Helsinki. Due to the retrospective design of the study, the requirement for informed consent, including parental or legal guardian consent for participants younger than 16 years of age, was waived by the ethics committee. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/19 04:00 MHDA- 2026/10/15 07:17 PMCR- 2026/07/18 CRDT- 2026/07/18 23:25 PHST- 2026/05/09 00:00 [received] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/10/15 07:17 [medline] PHST- 2026/07/19 04:00 [pubmed] PHST- 2026/07/18 23:25 [entrez] PHST- 2026/07/18 00:00 [pmc-release] AID - 10.1186/s12887-026-07308-1 [pii] AID - 7308 [pii] AID - 10.1186/s12887-026-07308-1 [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 18;26(1):1003. doi: 10.1186/s12887-026-07308-1. PMID- 42470661 OWN - NLM STAT- MEDLINE DCOM- 20260718 LR - 20260826 IS - 1532-7078 (Electronic) IS - 1525-0008 (Print) IS - 1532-7078 (Linking) VI - 31 IP - 4 DP - 2026 Jul-Aug TI - Brain Activity of Young Children in Bangladesh Is Associated With Biopsychosocial Conditions at the Individual-, Family-, and Household-Level. PG - e70108 LID - 10.1111/infa.70108 [doi] LID - e70108 AB - Adversities in early life compromise children's nurturing care and impact their development. This study explored the biopsychosocial conditions associated with electroencephalography (EEG)-based brain activity in children living in rural Bangladesh, a setting with high rates of malnutrition and suboptimal psychosocial stimulation. In a substudy of the Benefits and Risks of Iron Supplementation in Children (BRISC) study in Bangladesh, we recorded resting EEG brain activity in a random subsample of 440 children at 11 months and 594 children at 20 months of age. EEG band power measures were derived for delta, theta, alpha, and beta power bands. Validated tools were used to assess maternal depression, household food insecurity, and psychosocial stimulation. Children's anthropometry, venous hemoglobin and ferritin concentrations, and inflammation were also measured. Linear regression analyses were conducted to identify the concurrent and lagged biopsychosocial conditions associated with EEG-based brain activity. Growth, nutritional status, psychosocial stimulation, and household food security were associated with concurrent and lagged brain activity. The direction of association differed by EEG frequency band, but the majority of biopsychosocial conditions were positively associated with activity in the higher frequency bands and negatively with lower frequency bands. Our findings indicate that brain activity in children can be influenced by a range of biopsychosocial adversities. Children's nutrition, quality and quantity of psychosocial stimulation, and food security influence their current and later brain activity in this resource-limited setting in South Asia. TRIAL REGISTRATION: ACTRN12617000660381. CI - (c) 2026 The Author(s). Infancy published by Wiley Periodicals LLC on behalf of International Congress of Infant Studies. FAU - Larson, Leila M AU - Larson LM AUID- ORCID: 0000-0002-2570-7323 AD - Department of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA. FAU - Feuerriegel, Daniel AU - Feuerriegel D AUID- ORCID: 0000-0002-0357-1920 AD - Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Victoria, Australia. FAU - Lall, Gitanjali AU - Lall G AD - Department of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA. FAU - Imrul Hasan, Mohammed AU - Imrul Hasan M AD - Maternal and Child Health Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. AD - Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia. FAU - Braat, Sabine AU - Braat S AD - Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia. AD - Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia. AD - Department of Infectious Diseases at the Peter Doherty Institute, The University of Melbourne, Melbourne, Victoria, Australia. FAU - Jin, Jerry AU - Jin J AD - Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Victoria, Australia. AD - Department of Infectious Diseases at the Peter Doherty Institute, The University of Melbourne, Melbourne, Victoria, Australia. FAU - Biggs, Beverley-Ann AU - Biggs BA AD - Department of Infectious Diseases at the Peter Doherty Institute, The University of Melbourne, Melbourne, Victoria, Australia. AD - The Victorian Infectious Diseases Service, The Royal Melbourne Hospital, Melbourne, Victoria, Australia. FAU - Bode, Stefan AU - Bode S AD - Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Victoria, Australia. AD - Division of Science, New York University Abu Dhabi, Abu Dhabi, UAE. FAU - Pasricha, Sant-Rayn AU - Pasricha SR AD - Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia. AD - Diagnostic Haematology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia. AD - Diagnostic Haematology and Clinical Haematology, The Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, Victoria, Australia. AD - Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia. FAU - Johnson, Katherine A AU - Johnson KA AUID- ORCID: 0000-0002-2029-163X AD - Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Victoria, Australia. FAU - Hamadani, Jena D AU - Hamadani JD AD - Maternal and Child Health Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. LA - eng GR - GNT1103262/National Health and Medical Research Council/ GR - GNT1159151/National Health and Medical Research Council/ GR - GNT1158696/National Health and Medical Research Council/ GR - University of Melbourne/ PT - Journal Article PL - United States TA - Infancy JT - Infancy : the official journal of the International Society on Infant Studies JID - 100890607 SB - IM MH - Humans MH - Bangladesh MH - Female MH - Electroencephalography MH - Infant MH - Male MH - *Brain/physiology MH - Nutritional Status MH - Rural Population MH - *Child Development/physiology MH - Family Characteristics PMC - PMC13380311 COIS- The authors declare no conflicts of interest. EDAT- 2026/07/19 01:03 MHDA- 2026/07/19 01:04 PMCR- 2026/07/18 CRDT- 2026/07/18 13:43 PHST- 2026/05/29 00:00 [revised] PHST- 2025/07/31 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/07/19 01:04 [medline] PHST- 2026/07/19 01:03 [pubmed] PHST- 2026/07/18 13:43 [entrez] PHST- 2026/07/18 00:00 [pmc-release] AID - INFA70108 [pii] AID - 10.1111/infa.70108 [doi] PST - ppublish SO - Infancy. 2026 Jul-Aug;31(4):e70108. doi: 10.1111/infa.70108. PMID- 42468724 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260923 IS - 1541-6100 (Electronic) IS - 0022-3166 (Print) IS - 0022-3166 (Linking) VI - 156 IP - 9 DP - 2026 Sep TI - Longitudinal Changes in Healthy Eating Index-2020 Score and Impacts on Body Mass Index among Adolescents in the Growing Up Today Study: A Prospective Cohort Study. PG - 101735 LID - S0022-3166(26)00384-6 [pii] LID - 10.1016/j.tjnut.2026.101735 [doi] AB - BACKGROUND: The Dietary Guidelines for Americans informs the design of nutrition programs targeted at improving health across the life course, including for adolescents, a population with suboptimal diet quality. The associations between adherence to the Guidelines and longitudinal health outcomes among adolescents, however, are unclear. OBJECTIVES: We leveraged 7 y of data from the Growing Up Today Study, a prospective cohort study, to evaluate associations between concurrent changes in total or component Healthy Eating Index-2020 (HEI-2020) scores, a measure of adherence to the Guidelines, and changes in body mass index [BMI (in kg/m(2))], a targeted outcome of the Guidelines, in United States adolescents. METHODS: We analyzed data from a prospective longitudinal cohort with enrollment cycles in 1996 (n = 14,233) and 2004 (n = 7898). We calculated HEI-2020 and BMI from validated food frequency questionnaires and self-reported height/weight. Multivariate fixed-effects regression models, stratified by sex, were used to estimate associations between within-child changes in HEI-2020 and changes in BMI. We assessed interactions by concurrent adolescent BMI category and age. RESULTS: After covariate adjustment, a 10-point increase in total HEI-2020 was associated with 0.09 [95% confidence interval (CI): 0.051, 0.121] and 0.04 (95% CI: 0.011, 0.066) decreases in BMI for boys and girls, respectively. Of the 13 HEI-2020 components, only the greens/beans, fatty acids adequacy scores, and saturated fatty acid moderation scores were inversely related to BMI. A 1-point increase in the dairy component was associated with mean increases of 0.02 for boys and girls. Associations between total HEI-2020 and BMI were stronger for youth classified as overweight/obese and for older age, although associations were still relatively small. CONCLUSIONS: Improved adherence to the Dietary Guidelines, 2020-2025, was associated with small, though clinically insignificant, decreases in mean BMI among adolescents. Relationships for specific HEI components were heterogeneous and warrant further study. CI - Copyright (c) 2026 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Lee, Matthew M AU - Lee MM AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States. Electronic address: matthewlee@kurtosisresearch.com. FAU - Poole, Mary Kathryn AU - Poole MK AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Chen, Jarvis T AU - Chen JT AD - Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Gortmaker, Steven L AU - Gortmaker SL AD - Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Stephenson, Briana Joy K AU - Stephenson BJK AD - Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Haines, Jess AU - Haines J AD - Department of Family Relations & Applied Nutrition, University of Guelph, Guelph, ON, Canada. FAU - Chavarro, Jorge E AU - Chavarro JE AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States. FAU - Diamantis, Dimitrios V AU - Diamantis DV AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Kenney, Erica L AU - Kenney EL AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, United States. LA - eng GR - T32 HL098048/HL/NHLBI NIH HHS/United States GR - U01 CA176726/CA/NCI NIH HHS/United States GR - U01 HL145386/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20260717 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 SB - IM MH - Humans MH - *Body Mass Index MH - Adolescent MH - Female MH - Prospective Studies MH - *Diet, Healthy MH - Male MH - Longitudinal Studies MH - Nutrition Policy MH - Child MH - United States PMC - PMC13531323 MID - NIHMS2202929 OTO - NOTNLM OT - BMI OT - Dietary Guidelines for Americans OT - Growing Up Today Study OT - Healthy Eating Index OT - child nutrition OT - diet quality OT - longitudinal cohort study OT - nutrition epidemiology OT - obesity OT - prospective cohort study COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/07/18 00:38 MHDA- 2026/09/04 23:36 PMCR- 2026/09/02 CRDT- 2026/07/17 19:12 PHST- 2026/04/28 00:00 [received] PHST- 2026/06/22 00:00 [revised] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/09/04 23:36 [medline] PHST- 2026/07/18 00:38 [pubmed] PHST- 2026/07/17 19:12 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - S0022-3166(26)00384-6 [pii] AID - 10.1016/j.tjnut.2026.101735 [doi] PST - ppublish SO - J Nutr. 2026 Sep;156(9):101735. doi: 10.1016/j.tjnut.2026.101735. Epub 2026 Jul 17. PMID- 42464261 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261014 IS - 1465-993X (Electronic) IS - 1465-9921 (Print) IS - 1465-9921 (Linking) VI - 27 IP - 1 DP - 2026 Jul 17 TI - Aspartame and asthma: immunomodulatory effects on airway inflammation. LID - 10.1186/s12931-026-03820-1 [doi] LID - 393 AB - BACKGROUND AND OBJECTIVE: Asthma is a heterogeneous inflammatory airway disease influenced by genetic and environmental factors, including diet. Aspartame, a widely used artificial sweetener, has been implicated in immunometabolic changes that may affect asthma risk, but the potential role evidence remains limited. We aimed to examine the association between aspartame intake and asthma outcomes using integrated human analyses and complementary animal experiments. METHODS: Human data were obtained from 1021 adolescents in the Taiwan Puberty Longitudinal Study. Aspartame consumption, assessed using a validated food frequency questionnaire, was categorized as none, low, or high based on median intake. Asthma status was determined based on physician diagnosis and symptom history. In parallel, BALB/c mice were sensitized with house dust mite (HDM) extract and administered oral aspartame at 15, 30, or 60 mg/kg/day for 10 weeks. Immunological, microbiome, metabolic, and histopathological parameters were evaluated. RESULTS: Low aspartame consumption was significantly associated with higher odds of asthma (odds ratio = 2.852; 95% confidence interval: 1.038-8.014; p = 0.0369). In mice, aspartame exposure increased serum IgE levels, airway inflammation, and MMP-12 and MCP-1 expression. Although lung function changes were not statistically significant, histological analyses revealed more pronounced goblet cell hyperplasia, peribronchial collagen deposition, and eosinophilic infiltration, especially in the 60 mg/kg group. Aspartame also reduced microbial alpha-diversity and altered microbial composition. Short-chain fatty acids profiling revealed significantly decreased isobutyric, hexanoic, and heptanoic acid levels in aspartame-treated mice. CONCLUSIONS: Aspartame intake exacerbates asthma-related immunological, microbial, and histological disturbances. CI - (c) 2026. The Author(s). FAU - Utami, Fasty Arum AU - Utami FA AD - School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, 110, Taiwan. AD - Department of Nutrition and Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia. FAU - Huang, Shih-Yi AU - Huang SY AD - School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, 110, Taiwan. FAU - Liu, Yu-Hsiang AU - Liu YH AD - Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. FAU - Hsu, Jhih-Wei AU - Hsu JW AD - Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. FAU - Mazariegos, Jose Roberto Rodriguez AU - Mazariegos JRR AD - College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. AD - Faculty of Health Sciences, Rafael Landivar University, Guatemala City, 01016, Guatemala. FAU - Nguyen, Nam Nhat AU - Nguyen NN AD - Endocrinology Clinic, Hanh Phuc International Hospital, Ho Chi Minh City, 700000, Vietnam. FAU - Huang, Shiu-Wen AU - Huang SW AD - Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. AD - Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. FAU - Weng, Chih-Ming AU - Weng CM AD - School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. FAU - Chuang, Hsiao-Chi AU - Chuang HC AD - School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. FAU - Huang, Chung-Hsiung AU - Huang CH AD - Department of Food Science, National Taiwan Ocean University, Keelung, 202301, Taiwan. FAU - Tsai, Wan-Ling AU - Tsai WL AD - School of Nursing, College of Nursing, Fooyin University, Kaohsiung, 831, Taiwan. FAU - Chen, Yang-Ching AU - Chen YC AD - School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, 110, Taiwan. melisa26@tmu.edu.tw. AD - Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. melisa26@tmu.edu.tw. AD - Department of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, 11696, Taiwan. melisa26@tmu.edu.tw. AD - Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. melisa26@tmu.edu.tw. AD - Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, 110, Taiwan. melisa26@tmu.edu.tw. AD - Nutrition Research Center, Taipei Medical University Hospital, Taipei, 110, Taiwan. melisa26@tmu.edu.tw. AD - TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, 110, Taiwan. melisa26@tmu.edu.tw. AD - Child Development Research Center, Taipei Medical University Hospital, Taipei, 110, Taiwan. melisa26@tmu.edu.tw. LA - eng GR - 113-2628-B-038-006-MY3/National Science and Technology Council/ GR - 112TMU-TMUH-02-1 and 113TMU-TMUH-01/Taipei Medical University Hospital/ PT - Journal Article DEP - 20260717 PL - England TA - Respir Res JT - Respiratory research JID - 101090633 RN - Z0H242BBR1 (Aspartame) RN - 0 (Sweetening Agents) SB - IM MH - Animals MH - *Asthma/immunology/chemically induced/epidemiology/metabolism MH - Humans MH - *Aspartame/administration & dosage/adverse effects MH - Adolescent MH - Male MH - Female MH - Mice, Inbred BALB C MH - Mice MH - Longitudinal Studies MH - Taiwan/epidemiology MH - *Lung/drug effects/immunology/metabolism MH - *Sweetening Agents/administration & dosage/adverse effects MH - Dose-Response Relationship, Drug PMC - PMC13656438 OTO - NOTNLM OT - Airway Inflammation OT - Aspartame OT - Asthma OT - Microbiota OT - Non-nutritive Sweeteners OT - Short-chain fatty acids COIS- Declarations. Ethics approval and consent to participate: The human study protocol was approved by the Institutional Review Board of Taipei Medical University (N202203060) and conducted according to the Declaration of Helsinki. Written informed consent was obtained from both parents/guardians and participating children. Animal procedures were approved by the Taipei Medical University IACUC (LAC2022-0241, LAC2023-0236) and complied with institutional and international animal care guidelines. Consent for publication: Written informed consent for publication of the study data, including any potentially identifiable information, was obtained from all participating children and their parents or legal guardians. Competing interests: The authors declare no competing interests. EDAT- 2026/07/17 06:44 MHDA- 2026/10/12 05:32 PMCR- 2026/07/17 CRDT- 2026/07/17 00:51 PHST- 2025/10/30 00:00 [received] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/10/12 05:32 [medline] PHST- 2026/07/17 06:44 [pubmed] PHST- 2026/07/17 00:51 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - 10.1186/s12931-026-03820-1 [pii] AID - 3820 [pii] AID - 10.1186/s12931-026-03820-1 [doi] PST - epublish SO - Respir Res. 2026 Jul 17;27(1):393. doi: 10.1186/s12931-026-03820-1. PMID- 42462817 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260923 IS - 1938-3207 (Electronic) IS - 0002-9165 (Print) IS - 0002-9165 (Linking) VI - 124 IP - 3 DP - 2026 Sep TI - Metabolites co-correlating with maternal obesity and gestational weight gain and offspring childhood obesity: a prospective birth cohort study. PG - 101437 LID - S0002-9165(26)00246-7 [pii] LID - 10.1016/j.ajcnut.2026.101437 [doi] AB - BACKGROUND: Elevated prepregnancy body mass index (ppBMI) and excessive gestational weight gain (GWG) may contribute to the development of childhood overweight or obesity (COWO), potentially by altering the intrauterine metabolic environment. OBJECTIVES: This study aimed to evaluate the impact of maternal obesity phenotypes on maternal and umbilical cord blood metabolomic profiles, both individually and collectively, and to further examine their association with COWO incidence from preschool through adolescence. METHODS: We analyzed 1253 mother-child dyads with maternal metabolomic data collected 1 to 3 d postpartum and 856 dyads with cord metabolomic data from a prospective multiethnic birth cohort. Metabolomics was profiled using liquid chromatography-tandem mass spectrometry. COWO was defined as a BMI >/= 85th percentile for a specific age and sex. Metabolomic signatures of maternal obesity and scores were derived using linear regression and elastic net regression, and their associations with COWO were assessed via logistic regression. RESULTS: Most maternal metabolites were significantly correlated with corresponding cord metabolites (Spearman's rho: 0.11-0.67; adjusted P < 0.05), except for steroids and certain phospholipids. ppBMI was significantly associated with broad-based alterations in maternal metabolite profiles, particularly medium-chain acylcarnitines, saturated sphingomyelins, triacylglycerols, and phospholipids carrying PUFAs. We further developed ppBMI-related multi-metabolite scores (Pearson's r = 0.43-0.64) that were associated with higher birthweight (beta = 0.07-0.11; P < 0.013) and increased COWO risk (odds ratio: 1.18-1.61; all P < 0.05) from preschool through adolescence. A similar pattern was observed for GWG. In mediation analyses, the maternal metabolite score explained 12.3% (95% confidence interval: 2.18, 24.5; P = 0.02) of the association between ppBMI and BMI z-score at the last well-child visit. CONCLUSIONS: Metabolomic profiles are associated with and may partly mediate the association between maternal obesity, particularly ppBMI, and an increased risk of COWO. These findings warrant validation in independent cohorts. CI - Copyright (c) 2026 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Yun, Huan AU - Yun H AD - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Meir, Anat Yaskolka AU - Meir AY AD - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Hu, Jie AU - Hu J AD - Epidemiology and Center for Genomic Medicine and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States. FAU - Wang, Guoying AU - Wang G AD - Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, John Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States. FAU - Hu, Frank B AU - Hu FB AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States. FAU - Hong, Xiumei AU - Hong X AD - Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, John Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States. FAU - Wang, Xiaobin AU - Wang X AD - Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, John Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, United States. FAU - Liang, Liming AU - Liang L AD - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States. Electronic address: lliang@hsph.harvard.edu. LA - eng GR - R01 ES031521/ES/NIEHS NIH HHS/United States GR - R21 AI171059/AI/NIAID NIH HHS/United States GR - R01 ES031272/ES/NIEHS NIH HHS/United States GR - R21 HD116039/HD/NICHD NIH HHS/United States GR - U01 ES034983/ES/NIEHS NIH HHS/United States GR - R01 HD041702/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20260716 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Gestational Weight Gain MH - Prospective Studies MH - Child, Preschool MH - *Pediatric Obesity/etiology/metabolism/epidemiology MH - Birth Cohort MH - Child MH - Body Mass Index MH - *Pregnancy in Obesity/metabolism MH - Male MH - Fetal Blood/metabolism MH - Adult MH - Adolescent MH - *Metabolome MH - Metabolomics MH - Developmental Origins of Health and Disease MH - *Obesity PMC - PMC13390791 MID - NIHMS2196151 OTO - NOTNLM OT - birth cohort OT - childhood overweight or obesity OT - gestational weight gain OT - metabolome OT - prepregnancy BMI COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/07/17 00:42 MHDA- 2026/09/01 23:34 PMCR- 2026/07/23 CRDT- 2026/07/16 19:11 PHST- 2026/01/22 00:00 [received] PHST- 2026/07/10 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/09/01 23:34 [medline] PHST- 2026/07/17 00:42 [pubmed] PHST- 2026/07/16 19:11 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - S0002-9165(26)00246-7 [pii] AID - 10.1016/j.ajcnut.2026.101437 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Sep;124(3):101437. doi: 10.1016/j.ajcnut.2026.101437. Epub 2026 Jul 16. PMID- 42462582 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260831 IS - 1872-8464 (Electronic) IS - 0165-5876 (Linking) VI - 208 DP - 2026 Sep TI - Evaluation of anatomical and ultrasonographic parameters to predict difficult airway in pediatric patients. PG - 112932 LID - S0165-5876(26)00228-4 [pii] LID - 10.1016/j.ijporl.2026.112932 [doi] AB - BACKGROUND: Predicting a difficult airway in pediatric patients remains challenging due to unique anatomical and physiological characteristics. Traditional bedside predictors show inconsistent accuracy in children, and ultrasonography has emerged as a promising, objective tool for airway evaluation. This study aimed to assess the diagnostic performance of anatomical and ultrasonographic parameters in predicting difficult intubation in pediatric patients. METHODS: In this prospective, double-blind observational study, children aged 1-12 years undergoing elective surgery with endotracheal intubation were evaluated. Clinical assessments included anthropometric measurements and airway tests (Mallampati, thyromental distance (TMD), sternomental distance (SMD), hyomental distance (HMD)). Sonographic measurements-skin-epiglottis distance (S-ED) and skin-hyoid distance (S-HD)-were obtained preoperatively. Difficult intubation was defined as Intubation Difficulty Score (IDS) > 5. ROC curve analyses were used to evaluate diagnostic performance; logistic regression identified independent predictors. RESULTS: A total of 240 children were included, with a difficult-intubation incidence of 20%. S-ED demonstrated the highest predictive accuracy (AUC 0.941), followed by S-HD (AUC 0.912), HMD (AUC 0.898), and Mallampati classification (AUC 0.860). TMD and SMD showed moderate predictive ability. Combining significant clinical and sonographic parameters improved diagnostic performance, with S-ED + S-HD yielding an AUC of 0.961. Multivariable regression identified S-ED (OR 4.61), S-HD (OR 1.76), Mallampati >/= III, and facial anomalies as independent predictors of difficult intubation. The final model correctly classified 95.4% of cases. CONCLUSIONS: Ultrasonographic parameters, particularly S-ED and S-HD, are highly accurate predictors of difficult intubation in children and outperform traditional clinical tests. Combining sonographic with anatomical assessments significantly enhances diagnostic performance. Airway ultrasound provides an objective, reproducible, and non-cooperation-dependent tool that can improve preoperative risk stratification in pediatric anesthesia. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Altun, Demet AU - Altun D AD - Istanbul University, Istanbul Faculty of Medicine, Department of Anesthesiology, Istanbul, Turkey. Electronic address: drdemetaltun@hotmail.com. FAU - Canbaz, Mert AU - Canbaz M AD - Istanbul University, Istanbul Faculty of Medicine, Department of Anesthesiology, Istanbul, Turkey. FAU - Dincer, Muserref Beril AU - Dincer MB AD - Istanbul University, Istanbul Faculty of Medicine, Department of Anesthesiology, Istanbul, Turkey. FAU - Demirel, Ebru Emre AU - Demirel EE AD - Istanbul University, Istanbul Faculty of Medicine, Department of Anesthesiology, Istanbul, Turkey. FAU - Altun, Dilek AU - Altun D AD - Acibadem Mehmet Ali Aydinlar University, Department of Anesthesiology and Reanimation, Istanbul, Turkey. FAU - Kara, Hakan AU - Kara H AD - Istanbul Faculty of Medicine, Department of Otolaryngology & Head and Neck Surgery, Istanbul, Turkey. FAU - Sivrikoz, Nukhet AU - Sivrikoz N AD - Istanbul University, Istanbul Faculty of Medicine, Department of Anesthesiology, Istanbul, Turkey. FAU - Camci, Emre AU - Camci E AD - Istanbul University, Istanbul Faculty of Medicine, Department of Anesthesiology, Istanbul, Turkey. LA - eng PT - Journal Article PT - Observational Study DEP - 20260716 PL - Ireland TA - Int J Pediatr Otorhinolaryngol JT - International journal of pediatric otorhinolaryngology JID - 8003603 SB - IM MH - Humans MH - Child, Preschool MH - Female MH - Male MH - Child MH - Prospective Studies MH - *Intubation, Intratracheal/methods/adverse effects MH - Infant MH - Ultrasonography MH - Double-Blind Method MH - Predictive Value of Tests MH - ROC Curve MH - Elective Surgical Procedures/methods MH - Pediatric Anesthesia MH - *Airway Management/methods OTO - NOTNLM OT - Airway assessment OT - Difficult airway OT - Pediatric anesthesia OT - Pediatric intubation OT - Skin-epiglottis distance OT - Ultrasonography COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/17 04:03 MHDA- 2026/08/18 23:36 CRDT- 2026/07/16 18:08 PHST- 2026/06/02 00:00 [received] PHST- 2026/07/10 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/08/18 23:36 [medline] PHST- 2026/07/17 04:03 [pubmed] PHST- 2026/07/16 18:08 [entrez] AID - S0165-5876(26)00228-4 [pii] AID - 10.1016/j.ijporl.2026.112932 [doi] PST - ppublish SO - Int J Pediatr Otorhinolaryngol. 2026 Sep;208:112932. doi: 10.1016/j.ijporl.2026.112932. Epub 2026 Jul 16. PMID- 42462323 OWN - NLM STAT- MEDLINE DCOM- 20260810 LR - 20260810 IS - 1878-5506 (Electronic) IS - 1389-9457 (Linking) VI - 147 DP - 2026 Nov TI - Sleep patterns and determinants of sleep disturbances in preschool children in the CoAlHaS cohort. PG - 109143 LID - S1389-9457(26)00382-5 [pii] LID - 10.1016/j.sleep.2026.109143 [doi] AB - INTRODUCTION: Sleep disturbances represent a significant public health concern from early childhood, given the long-term implications for health and development. This study examined sleep patterns and factors associated with sleep disturbances in preschool-aged children. METHODS: Data were collected from 1287 participants (544 born in 2018 and 743 born in 2020/21) within the CoAlHaS cohort (Cantabria, Spain). Baseline information was obtained at birth, with follow-up data collected through face-to-face visits, including parent interviews, anthropometric measurements and linkage to medical records. Sleep patterns and disturbances were assessed by the Spanish version of the Children's Sleep Habits Questionnaire (CSHQ-SP). Children were classified as 'poor sleepers' using the validated Spanish threshold of 50.35 points. Associations with perinatal, lifestyle and sociodemographic factors were analysed using one-way ANOVA, independent-samples t-tests and multivariable logistic regression. RESULTS: The prevalence of sleep problems was 36.22% in the total sample. Recommended sleep duration was generally met, although patterns varied between cohorts. Globally, prematurity (OR 2.10, 95% CI 1.24-3.56), increased screen time exposure (OR 1.06, 95% CI 1.01-1.10) and late bedtimes (OR 1.46, 95% CI 0.99-2.13) were linked to being a poor sleeper, whereas higher maternal educational attainment (OR 0.62, 95% CI 0.40-0.96) and younger age (OR 0.24, 95% CI 0.07-0.77) were associated with reduced odds. CONCLUSION: Sleep disturbances are frequent among early childhood, despite achieving recommended sleep duration. Early identification of children at risk and targeted interventions focusing on sleep routines and modifiable family-level factors could be essential to improve sleep habits. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Sanchez-Piorno, L AU - Sanchez-Piorno L AD - Preventive Medicine Group, University of Cantabria, IDIVAL-Valdecilla Health Research Institute, Santander, Spain. FAU - Gomez-Acebo, I AU - Gomez-Acebo I AD - Preventive Medicine Group, University of Cantabria, IDIVAL-Valdecilla Health Research Institute, Santander, Spain; CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain. FAU - Alonso-Molero, J AU - Alonso-Molero J AD - Preventive Medicine Group, University of Cantabria, IDIVAL-Valdecilla Health Research Institute, Santander, Spain; CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain. FAU - Valero-Dominguez, S AU - Valero-Dominguez S AD - Preventive Medicine Group, University of Cantabria, IDIVAL-Valdecilla Health Research Institute, Santander, Spain; RICORS Node - Carlos III Health Institute, Madrid, Spain. FAU - Llorente-Pelayo, S AU - Llorente-Pelayo S AD - Department of Pediatrics, Marques de Valdecilla University Hospital, IDIVAL-Valdecilla Health Research Institute, Santander, Spain. FAU - Lechosa-Muniz, C AU - Lechosa-Muniz C AD - RICORS Node - Carlos III Health Institute, Madrid, Spain; Department of Pediatrics, Marques de Valdecilla University Hospital, IDIVAL-Valdecilla Health Research Institute, Santander, Spain. FAU - Cabero-Perez, M AU - Cabero-Perez M AD - RICORS Node - Carlos III Health Institute, Madrid, Spain; Department of Pediatrics, Marques de Valdecilla University Hospital, IDIVAL-Valdecilla Health Research Institute, Santander, Spain. FAU - Dierssen-Sotos, T AU - Dierssen-Sotos T AD - Preventive Medicine Group, University of Cantabria, IDIVAL-Valdecilla Health Research Institute, Santander, Spain; CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain. Electronic address: trinidad.dierssen@unican.es. LA - eng PT - Journal Article DEP - 20260715 PL - Netherlands TA - Sleep Med JT - Sleep medicine JID - 100898759 SB - IM MH - Humans MH - Child, Preschool MH - Female MH - *Sleep Wake Disorders/epidemiology MH - Male MH - Surveys and Questionnaires MH - Prevalence MH - Spain/epidemiology MH - Sleep Duration MH - Cohort Studies MH - *Sleep/physiology MH - Risk Factors OTO - NOTNLM OT - Child OT - Preschool OT - Preterm birth OT - Screen time OT - Sleep wake disorders OT - Socioeconomic factors COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/16 22:01 MHDA- 2026/08/11 00:35 CRDT- 2026/07/16 18:00 PHST- 2026/03/12 00:00 [received] PHST- 2026/07/14 00:00 [revised] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/08/11 00:35 [medline] PHST- 2026/07/16 22:01 [pubmed] PHST- 2026/07/16 18:00 [entrez] AID - S1389-9457(26)00382-5 [pii] AID - 10.1016/j.sleep.2026.109143 [doi] PST - ppublish SO - Sleep Med. 2026 Nov;147:109143. doi: 10.1016/j.sleep.2026.109143. Epub 2026 Jul 15. PMID- 42461426 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20261008 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 30 IP - 8 DP - 2026 Jul 16 TI - Association of salivary dynamics, psychological stress, and behavioral factors with tooth wear severity: a cross-sectional study. LID - 339 [pii] LID - 10.1007/s00784-026-07029-w [doi] AB - OBJECTIVES: While the etiology of tooth wear is known to be multifactorial, data regarding the interaction between psychological profile, salivary dynamics, and clinical wear severity remain insufficiently elucidated. This study aimed to analyze the effects of psychological profile and salivary parameters-alongside demographic data, medical history, oral hygiene habits, and dietary patterns-on the severity of clinical tooth wear in a multivariable framework. MATERIALS AND METHODS: Following institutional ethical approval and informed consent, this cross-sectional study included 101 volunteers (90% power), categorized by stress severity (DASS-21: normal, mild, moderate, severe, extremely severe), age groups (18-30, 31-40, 41-50, 51-60, 61-65 years) and salivary pH/buffering capacity levels (low, intermediate, high) for intergroup comparisons. Clinical wear severity was assessed using the Smith and Knight Tooth Wear Index (TWI); psychometric profiles were evaluated via the Depression Anxiety Stress Scale-21 (DASS-21). Salivary analyses (unstimulated pH and stimulated buffering capacity) utilized the GC Saliva-Check Buffer kit. Data were analyzed using independent t-tests, one-way ANOVA, and six-block hierarchical multiple linear regression (p < 0.05). RESULTS: The mean age was 46.7 years; significant differences in TWI scores existed among five age groups (18-30, 31-40, 41-50, 51-60, and 61-65 years; p < 0.05), with the highest wear severity observed in the 61-65 age group (Mean: 2.63). Severe stress (p = 0.008), low salivary pH and insufficient buffering capacity (p = 0.001), and acidic beverage consumption without a straw (p = 0.001) were significantly associated with higher TWI scores. In hierarchical regression, salivary buffering capacity (beta = -0.289), straw use (beta = -0.248), and salivary pH (beta = -0.228) emerged as independent predictors of wear severity (R(2) = 0.519), whereas psychological variables did not contribute independently. CONCLUSIONS: These observational findings suggest that tooth wear severity is associated with the cumulative interplay of biological, behavioral, and psychological factors. Impaired salivary dynamics and specific behavioral patterns were the strongest independent correlates of wear severity; the role of psychological stress appears to operate indirectly, warranting further longitudinal investigation. CLINICAL RELEVANCE: These findings underline the potential value of considering salivary parameters and consumption-related behaviours when evaluating tooth wear risk in adults, while further longitudinal evidence is required before firm clinical recommendations can be made. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Yilmaz, Damla AU - Yilmaz D AUID- ORCID: 0009-0008-2602-877X AD - Department of Restorative Dentistry, Faculty of Dentistry, Necmettin Erbakan University, Konya, Turkiye. damlayylmz@gmail.com. FAU - Dereli, Zeynep AU - Dereli Z AUID- ORCID: 0000-0003-2317-9069 AD - Department of Restorative Dentistry, Faculty of Dentistry, Necmettin Erbakan University, Konya, Turkiye. LA - eng GR - Project No: 25DU24004/Necmettin Erbakan Universitesi/ GR - Project No: 25DU24004/Necmettin Erbakan Universitesi/ PT - Journal Article DEP - 20260716 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Middle Aged MH - Female MH - Adult MH - Male MH - *Stress, Psychological/complications MH - *Saliva/chemistry/metabolism MH - *Tooth Wear/psychology/etiology MH - Adolescent MH - Aged MH - Young Adult MH - Severity of Illness Index OTO - NOTNLM OT - Cross-sectional study OT - Hierarchical regression OT - Psychological stress OT - Salivary buffering capacity OT - Tooth wear COIS- Declarations. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Institutional Ethics Committee of Necmettin Erbakan University (Date: April 24, 2025/Decision No: 2025/580). Consent to participate: Written informed consent was obtained from all individual participants included in the study. Consent to publish: The authors affirm that human research participants provided informed consent for publication of the images in Fig. 2. Competing interests: The authors declare no competing interests. EDAT- 2026/07/16 16:06 MHDA- 2026/07/16 18:46 CRDT- 2026/07/16 11:15 PHST- 2026/03/07 00:00 [received] PHST- 2026/07/11 00:00 [accepted] PHST- 2026/07/16 18:46 [medline] PHST- 2026/07/16 16:06 [pubmed] PHST- 2026/07/16 11:15 [entrez] AID - 10.1007/s00784-026-07029-w [pii] AID - 10.1007/s00784-026-07029-w [doi] PST - epublish SO - Clin Oral Investig. 2026 Jul 16;30(8):339. doi: 10.1007/s00784-026-07029-w. PMID- 42459815 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20261013 IS - 1432-2277 (Electronic) IS - 0934-0874 (Print) IS - 0934-0874 (Linking) VI - 39 DP - 2026 TI - Landscape of current practices and future perspectives in living donor kidney donation in Europe: proceedings of a pan-European symposium by the European kidney transplant association section of the European Society for Organ Transplantation. PG - 16548 LID - 10.3389/ti.2026.16548 [doi] LID - 16548 AB - Living donor kidney transplantation (LDKT) offers superior outcomes for most patients with end-stage kidney disease (ESKD), yet its uptake across Europe remains highly variable. This proceedings article summarizes key themes from a pan-European symposium held in November 2025 in Prague, organized by the European Kidney Transplant Association (EKITA) in collaboration with the DESCaRTES Working Group. Discussions highlighted substantial heterogeneity in LDKT activity across Europe, driven by differences in healthcare capacity, legal frameworks, donor evaluation practices, and access to kidney exchange programmes. Marked inequities persist between regions, particularly in the Balkans and Western Balkans, for women those who are socioeconomically disadvantaged, ethnic minority populations, paediatric and elderly patients and individuals with obesity. The symposium identified wide variation in donor selection criteria, risk assessment, informed consent practices, and long-term donor follow-up, despite existing international guidelines. Emerging strategies to address these challenges include harmonisation of donor evaluation and consent, expansion of paired and cross-border kidney exchange programmes, increased use of unspecified kidney donation, and adoption of innovative surgical and immunological approaches to safely broaden donor eligibility. Advances in outcome measurement, including validated surrogate endpoints, machine learning methods, and integrated, harmonised transplant registries, were discussed as critical tools to improve quality, transparency, and research efficiency. Collectively, the proceedings underscore the need for coordinated clinical, policy, and data-driven solutions to reduce inequities and unlock the full potential of LDKT across Europe, with implications for international transplant practice. CI - Copyright (c) 2026 Kousios, Baas, Manonelles, Ortiz, Rista, Thomas, Lefaucheur, Akin and Marson. FAU - Kousios, Andreas AU - Kousios A AD - School of Medicine, European University Cyprus, Nicosia, Cyprus. AD - Nefrontida Medical Centre, Nicosia, Cyprus. FAU - Baas, Marije AU - Baas M AD - Department of Nephrology, Radboud University Medical Center, Radboud Universiteit, Nijmegen, Netherlands. FAU - Manonelles, Anna AU - Manonelles A AD - Renal Transplant Unit, Nephrology Department, Bellvitge University Hospital, Barcelona, Spain. FAU - Ortiz, Fernanda AU - Ortiz F AD - Abdominal Unit, Nephrology, Helsinki University Hospital, Helsinki, Finland. FAU - Rista, Elvana AU - Rista E AD - Department of Nephrology, Dialysis, and Kidney Transplantation, Hygeia International Hospital, Tirana, Albania. FAU - Thomas, Rachel AU - Thomas R AD - Edinburgh Transplant Centre, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom. FAU - Lefaucheur, Carmen AU - Lefaucheur C AD - Saint Louis Hospital, Assistance Publique- Hopiteux de Paris and Universite Paris Cite, Paris, France. FAU - Akin, Emin Baris AU - Akin EB AD - Department of General Surgery, Demiroglu Bilim University and Group Florence Nightingale Hospital, Istanbul, Turkiye. FAU - Marson, Lorna AU - Marson L AD - Edinburgh Transplant Centre, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom. LA - eng PT - Conference Proceedings DEP - 20260701 PL - Switzerland TA - Transpl Int JT - Transplant international : official journal of the European Society for Organ Transplantation JID - 8908516 SB - IM EIN - Transpl Int. 2026 Sep 28;39:17772. doi: 10.3389/ti.2026.17772. PMID: 42866521 MH - Humans MH - *Kidney Transplantation/methods/trends MH - *Living Donors MH - Europe MH - *Kidney Failure, Chronic/surgery MH - *Tissue and Organ Procurement/trends MH - Female MH - Donor Selection MH - Informed Consent MH - Risk Assessment PMC - PMC13368691 OTO - NOTNLM OT - cross-border organ exchange OT - donor evaluation and safety OT - equity in transplantation OT - living donor kidney transplantation OT - transplant registry harmonisation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/16 06:34 MHDA- 2026/07/16 13:02 PMCR- 2026/07/01 CRDT- 2026/07/16 04:39 PHST- 2026/03/10 00:00 [received] PHST- 2026/05/29 00:00 [revised] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/07/16 13:02 [medline] PHST- 2026/07/16 06:34 [pubmed] PHST- 2026/07/16 04:39 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - 16548 [pii] AID - 10.3389/ti.2026.16548 [doi] PST - epublish SO - Transpl Int. 2026 Jul 1;39:16548. doi: 10.3389/ti.2026.16548. eCollection 2026. PMID- 42458481 OWN - NLM STAT- MEDLINE DCOM- 20260723 LR - 20260822 IS - 1479-5876 (Electronic) IS - 1479-5876 (Linking) VI - 24 IP - 1 DP - 2026 Jul 15 TI - Handgrip strength in children, adolescents, and young adults with suspected myalgic encephalomyelitis/chronic fatigue syndrome. LID - 10.1186/s12967-026-08654-5 [doi] LID - 947 AB - BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in children and young people (CYP) lacks validated diagnostic biomarkers. Post-exertional malaise (PEM) is central to case definitions and is usually assessed by patient report. We evaluated the feasibility and clinical value of handgrip strength (HGS) testing in PEM-reporting CYP referred for suspected ME/CFS. METHODS: In this prospective observational study at the Munich Chronic Fatigue Center for Young People (November 2022-November 2024), 147 patients (10-25 years) referred for the assessment of ME/CFS with positive DSQ-PEM screening and 83 healthy controls (HC) completed two HGS sessions (10 maximal grips/session; 3-s contraction/5-s rest; 60-minute inter-session break) using a digital dynamometer. We derived maximal force (Fmax), mean force (Fmean), fatigue ratio (FR = Fmax/Fmean), and recovery ratio (RR = Fmean session 2 / session 1). Analyses used repeated-measures ANCOVA, linear regression, partial Spearman correlations (adjusted for sex, age, and BMI), and proportional odds models for group membership (HC, noME/CFS, ME/CFS), reporting accuracy, and the C-statistic. Sensitivity analyses compared noME/CFS with confirmed CCC-ME/CFS. RESULTS: After clinical work-up, 84/147 (57%) patients were classified as ME/CFS (confirmed or probable) and 63/147 (43%) as noME/CFS. HGS test completion rate was high (session 1: 146/147, 99.3%; session 2: 142/147, 96.6%). Compared with HC, patients had substantially lower HGS (mean difference -9.93 kg, 95% CI: -12.00 to -7.85), and HGS indices correlated modestly with physical functioning (SF-12 PCS), but not with PEM duration. Both noME/CFS and ME/CFS groups differed from HC in absolute strength indices (Fmean, Fmax) and FR. RR differed between ME/CFS and HC, whereas no HGS index significantly separated noME/CFS from ME/CFS. In proportional odds models, each HGS index improved fit (all p < 0.001), but discrimination across HC, noME/CFS, and ME/CFS patients was moderate (accuracy 49.2-57.3% vs no-information rate 36.5%, with best performance for Fmean in session 2). In the CCC-restricted sensitivity analysis, discrimination between confirmed CCC-ME/CFS and noME/CFS was moderate (accuracy 62.8-70.7%; C-statistic 0.63-0.73), with best performance for absolute strength indices and RR. CONCLUSIONS: Standardized two-session repeated HGS testing is feasible in CYP with chronic fatigue and self-reported PEM and provides an objective marker of functional impairment that aligns with physical health status but not with PEM duration. However, HGS alone shows limited ability to discriminate ME/CFS from other fatiguing noME/CFS conditions. HGS may be useful for quantitative phenotyping, patient stratification, and longitudinal outcome assessment rather than as a standalone diagnostic biomarker. TRIAL REGISTRATION: Not applicable. CI - (c) 2026. The Author(s). FAU - Mihatsch, Lorenz AU - Mihatsch L AUID- ORCID: 0000-0003-3835-7964 AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. L.Mihatsch@tum.de. FAU - Schartner, Lisa AU - Schartner L AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - de Luna, Julia Lange AU - de Luna JL AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Hohler, Chiara AU - Hohler C AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Bucka, Lara AU - Bucka L AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Lovrenovic, Lea AU - Lovrenovic L AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Eidenschink, Sophie AU - Eidenschink S AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Schmuck, Birgit AU - Schmuck B AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Bienemann, Viktoria AU - Bienemann V AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Christa, Catharina AU - Christa C AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Mittelstrass, Kirstin AU - Mittelstrass K AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Hausruckinger, Anna AU - Hausruckinger A AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Warlitz, Cordula AU - Warlitz C AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Michel, Kaja AU - Michel K AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Gerrer, Katrin AU - Gerrer K AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Freitag, Helma AU - Freitag H AD - Charite - Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Institute of Medical Immunology, Augustenburger Platz 1, Berlin, 13353, Germany. FAU - Scheibenbogen, Carmen AU - Scheibenbogen C AD - Charite - Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Institute of Medical Immunology, Augustenburger Platz 1, Berlin, 13353, Germany. FAU - Pricoco, Rafael AU - Pricoco R AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Behrends, Uta AU - Behrends U AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. AD - German Center for Infection Research, Partnersite Munich, Munich, Germany. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260715 PL - England TA - J Transl Med JT - Journal of translational medicine JID - 101190741 SB - IM MH - Humans MH - *Fatigue Syndrome, Chronic/physiopathology/diagnosis MH - *Hand Strength/physiology MH - Child MH - Adolescent MH - Female MH - Young Adult MH - Male MH - Adult MH - Case-Control Studies PMC - PMC13393269 OTO - NOTNLM OT - Handgrip strength OT - ME/CFS OT - PEM OT - Pediatrics OT - Post-COVID OT - Post-Exertional malaise OT - Post-Vaccination COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Institutional Review Board of the TUM University Hospital (2022-585_1) and adheres to the Declaration of Helsinki and its subsequent amendments. Written informed consent was obtained from all participants prior to their inclusion, and in case of minors, from their legal guardians. Consent for publication: Not applicable. Competing interest: U.B. reports research funding from the Bavarian State Ministry of Health and Care, the Bavarian State Ministry of Science and Art, the German Center for Infection Research (DZIF), the Federal Ministry of Research, Technology and Space, the Federal Ministry of Health, and the Federal Joint Committee. All other authors report no conflict of interest. EDAT- 2026/07/16 00:35 MHDA- 2026/07/23 06:39 PMCR- 2026/07/15 CRDT- 2026/07/16 00:01 PHST- 2026/03/08 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/07/23 06:39 [medline] PHST- 2026/07/16 00:35 [pubmed] PHST- 2026/07/16 00:01 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - 10.1186/s12967-026-08654-5 [pii] AID - 8654 [pii] AID - 10.1186/s12967-026-08654-5 [doi] PST - epublish SO - J Transl Med. 2026 Jul 15;24(1):947. doi: 10.1186/s12967-026-08654-5. PMID- 42455961 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1520-7560 (Electronic) IS - 1520-7552 (Print) IS - 1520-7552 (Linking) VI - 42 IP - 5 DP - 2026 Jul TI - Disordered Eating Behaviours and Associated Factors Among People With Type 1 Diabetes: A Cross-Sectional Study in Spain-D1ANAS Project. PG - e70204 LID - 10.1002/dmrr.70204 [doi] LID - e70204 AB - BACKGROUND AND AIMS: People with type 1 diabetes mellitus (T1D) are at increased risk of disordered eating behaviours (DEBs), partly due to aspects of diabetes management. The aim of this study was to estimate the prevalence of DEBs in a group of adults with T1D in Spain and to examine their association with sociodemographic, clinical, and lifestyle-related factors. METHODS: A nationwide cross-sectional study was conducted as part of the D1ANAS project, involving 451 people aged >/= 16 years with T1D living in Spain. DEBs were assessed using the validated Spanish version of the Diabetes Eating Problems Survey-Revised (DEPS-R), with scores >/= 20 indicating a positive screening. Sociodemographic, clinical, and lifestyle variables were collected using a self-administered online questionnaire. Multivariate linear regression analyses were performed to identify factors independently associated with the total DEPS-R score. RESULTS: The mean DEPS-R score was 16.8 (SD 12.1), and 31.7% of participants screened positive for DEBs, with higher prevalence in women than men (35.4% vs. 14.8%, p < 0.001) 36.6% of participants reported insulin restriction behaviours, with no significant differences between sexes. In the adjusted models, female sex (beta = 3.23, 95% CI = 0.65-5.82), higher HbA1c percentage (beta = 2.12, 95% CI = 1.32-2.93), and higher zBMI (beta = 3.44, 95% CI = 2.44-4.44) were independently associated with higher DEPS-R scores, as were poorer perceived health (beta = 5.11, 95% CI = 2.25-7.96), poorer diet quality (beta = 13.42, 95% CI = 7.23-19.61) and poor sleep perception (beta = 3.43, 95% CI = 1.46-5.39). The model explained 29.6% of the variance in DEPS-R scores. CONCLUSION: DEBs affect about one-third of the participants with T1D and are associated with poorer metabolic control, higher BMI, and adverse lifestyle and psychosocial factors, highlighting the need for diabetes-specific screening and multidisciplinary management. CI - (c) 2026 The Author(s). Diabetes/Metabolism Research and Reviews published by John Wiley & Sons Ltd. FAU - Botella-Juan, Lorena AU - Botella-Juan L AUID- ORCID: 0000-0002-4886-1673 AD - Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Faculty of Health Sciences, Universidad de Leon, Leon, Spain. AD - Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiologia y Salud Publica [CIBERESP]), Madrid, Spain. AD - The Research Group in Gene‑Environment and Health Interactions (GIIGAS), Institute Biomedicine (IBIOMED), Universidad de Leon, Leon, Spain. FAU - Aguilera-Buenosvinos, Inmaculada AU - Aguilera-Buenosvinos I AUID- ORCID: 0000-0002-9484-7303 AD - Faculty of Health Sciences, International University of La Rioja, Logrono, Spain. FAU - Antequera-Gonzalez, Maria AU - Antequera-Gonzalez M AD - Servicio de Endocrinologia y Nutricion, Complejo Asistencial Universitario de Leon, Gerencia de Salud de Castilla y Leon (SACYL), Leon, Spain. FAU - Alvarez-Alvarez, Laura AU - Alvarez-Alvarez L AUID- ORCID: 0000-0002-4915-8314 AD - Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Faculty of Health Sciences, Universidad de Leon, Leon, Spain. AD - Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiologia y Salud Publica [CIBERESP]), Madrid, Spain. AD - The Research Group in Gene‑Environment and Health Interactions (GIIGAS), Institute Biomedicine (IBIOMED), Universidad de Leon, Leon, Spain. FAU - Rubin-Garcia, Maria AU - Rubin-Garcia M AUID- ORCID: 0000-0003-0916-4215 AD - Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Faculty of Health Sciences, Universidad de Leon, Leon, Spain. AD - Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiologia y Salud Publica [CIBERESP]), Madrid, Spain. AD - The Research Group in Gene‑Environment and Health Interactions (GIIGAS), Institute Biomedicine (IBIOMED), Universidad de Leon, Leon, Spain. FAU - Romeo-Santos, Maria AU - Romeo-Santos M AD - Hospital General Universitario Gregorio Maranon, Madrid, Spain. FAU - Segura-Grau, Ana AU - Segura-Grau A AUID- ORCID: 0000-0003-3701-2788 AD - Ultrasound Unit, Family and Community Medicine, San Francisco de Asis Hospital, Madrid, Spain. AD - SEMERGEN (Spanish Society of Primary Care Physicians), Madrid, Spain. FAU - Ballesteros-Pomar, Maria D AU - Ballesteros-Pomar MD AUID- ORCID: 0000-0002-5729-9926 AD - Servicio de Endocrinologia y Nutricion, Complejo Asistencial Universitario de Leon, Gerencia de Salud de Castilla y Leon (SACYL), Leon, Spain. AD - Instituto de Investigacion Biosanitaria de Leon (IBIOLEON), Leon, Spain. FAU - Molina, Antonio Jose AU - Molina AJ AUID- ORCID: 0000-0002-5948-6397 AD - Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Faculty of Health Sciences, Universidad de Leon, Leon, Spain. AD - Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiologia y Salud Publica [CIBERESP]), Madrid, Spain. AD - The Research Group in Gene‑Environment and Health Interactions (GIIGAS), Institute Biomedicine (IBIOMED), Universidad de Leon, Leon, Spain. FAU - Martin-Sanchez, Vicente AU - Martin-Sanchez V AUID- ORCID: 0000-0003-0552-2804 AD - Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Faculty of Health Sciences, Universidad de Leon, Leon, Spain. AD - Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiologia y Salud Publica [CIBERESP]), Madrid, Spain. AD - The Research Group in Gene‑Environment and Health Interactions (GIIGAS), Institute Biomedicine (IBIOMED), Universidad de Leon, Leon, Spain. LA - eng PT - Journal Article PL - England TA - Diabetes Metab Res Rev JT - Diabetes/metabolism research and reviews JID - 100883450 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/complications/psychology MH - Female MH - Cross-Sectional Studies MH - Male MH - *Feeding and Eating Disorders/epidemiology/etiology/psychology MH - Spain/epidemiology MH - Adult MH - Prevalence MH - Middle Aged MH - Young Adult MH - Adolescent MH - Risk Factors MH - Follow-Up Studies MH - *Feeding Behavior/psychology MH - Life Style MH - Prognosis MH - Surveys and Questionnaires PMC - PMC13372235 OTO - NOTNLM OT - diabetes mellitus OT - disordered eating behaviours OT - eating disorders OT - type 1 diabetes COIS- The authors declare no conflicts of interest. EDAT- 2026/07/15 18:41 MHDA- 2026/07/15 18:42 PMCR- 2026/07/15 CRDT- 2026/07/15 14:13 PHST- 2026/06/12 00:00 [revised] PHST- 2026/03/20 00:00 [received] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/07/15 18:42 [medline] PHST- 2026/07/15 18:41 [pubmed] PHST- 2026/07/15 14:13 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - DMRR70204 [pii] AID - 10.1002/dmrr.70204 [doi] PST - ppublish SO - Diabetes Metab Res Rev. 2026 Jul;42(5):e70204. doi: 10.1002/dmrr.70204. PMID- 42455824 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Reliability and validity of the individual GPS game data-based maximal acceleration-initial running speed regression line in youth elite soccer players. PG - e0353385 LID - 10.1371/journal.pone.0353385 [doi] LID - e0353385 AB - Modern load monitoring in soccer increasingly employs relative individualized acceleration intensity thresholds derived from individual maximal acceleration-initial running speed (amax-vinit) regression lines. This study examined the reliability and validity of soccer players' individual amax-vinit regression lines determined solely from game locomotion data. Using a GPS-based tracking system, we prospectively collected game locomotion data from 159 male youth elite soccer players over one season and repeatedly determined their amax-vinit regression lines using a recently introduced game data-based method. To examine the influence of data volume, regression lines were determined using different numbers of consecutive games. As a criterion measure, the amax-vinit regression line was determined using an acceleration test in 55 athletes. Reliability was assessed via the typical error (TE) and the intraclass correlation coefficient (ICC), and validity via the typical error of the estimate (TEE) and the Pearson correlation coefficient. The magnitude of errors and correlation coefficients was assessed using standardization and published thresholds, respectively. Reliability improved gradually with increasing data volume, resulting in TEs of 3.4% (amax intercept), 7.3% (vinit intercept), and 10.3% (slope). Nonetheless, all TEs were large in magnitude, and ICCs very low to low. Validity was unaffected by data volume, with TEEs consistently ~7% (amax intercept), ~ 12% (vinit intercept), and ~17% (slope). All TEEs were assessed as extremely large, and Pearson correlations as impractical. These findings indicate that the game data-based method currently lacks the precision required for individual-level applications, and this limitation cannot be resolved simply by including more games. Therefore, establishing relative individualized acceleration intensity thresholds within a team still requires a test-based approach. Moreover, the results suggest that properties inherent in GPS-based game locomotion data, rather than data volume, underlie the observed imprecision. We propose that substantial future improvements will depend on more precise tracking systems. CI - Copyright: (c) 2026 Andrey et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Andrey, Pascal AU - Andrey P AUID- ORCID: 0000-0002-0812-8899 AD - Department of Elite Sport, Swiss Federal Institute of Sport Magglingen SFISM, Magglingen, Bern, Switzerland. FAU - Fischer-Sonderegger, Karin AU - Fischer-Sonderegger K AD - Department of Elite Sport, Swiss Federal Institute of Sport Magglingen SFISM, Magglingen, Bern, Switzerland. FAU - Taube, Wolfgang AU - Taube W AD - Department of Neurosciences and Movement Science, University of Fribourg, Fribourg, Fribourg, Switzerland. FAU - Tschopp, Markus AU - Tschopp M AUID- ORCID: 0009-0007-3446-2907 AD - Department of Elite Sport, Swiss Federal Institute of Sport Magglingen SFISM, Magglingen, Bern, Switzerland. LA - eng PT - Journal Article DEP - 20260715 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Soccer/physiology MH - *Running/physiology MH - *Geographic Information Systems MH - Male MH - Reproducibility of Results MH - *Acceleration MH - Adolescent MH - *Athletes MH - *Athletic Performance/physiology MH - Regression Analysis PMC - PMC13372162 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/15 18:39 MHDA- 2026/07/15 18:40 PMCR- 2026/07/15 CRDT- 2026/07/15 13:43 PHST- 2025/11/19 00:00 [received] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/07/15 18:40 [medline] PHST- 2026/07/15 18:39 [pubmed] PHST- 2026/07/15 13:43 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - PONE-D-25-62317 [pii] AID - 10.1371/journal.pone.0353385 [doi] PST - epublish SO - PLoS One. 2026 Jul 15;21(7):e0353385. doi: 10.1371/journal.pone.0353385. eCollection 2026. PMID- 42453435 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260715 LR - 20260922 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Physical activity and adolescents' parasocial relationships with virtual idols: evidence from loneliness, gender differences, and network analysis. PG - 1854829 LID - 10.3389/fpsyg.2026.1854829 [doi] LID - 1854829 AB - INTRODUCTION: This study aimed to examine whether higher levels of physical activity were associated with adolescents' parasocial relationships with virtual idols through lower levels of loneliness, and to determine whether gender moderated these associations. The study also explored the item-level connections between loneliness and parasocial relationships with virtual idols. METHODS: A cross-sectional survey was conducted among 2,798 adolescents from Sichuan, Hunan, Yunnan, and Chongqing provinces in China. Physical activity, loneliness, and parasocial relationships with virtual idols were measured using validated questionnaires. The SPSS PROCESS macro was used to test the moderated mediation model, and network analysis was conducted to identify key bridging nodes between loneliness and parasocial relationships. RESULTS: Physical activity was significantly negatively associated with parasocial relationships with virtual idols, and loneliness showed a significant partial statistical mediation in this association. Gender significantly moderated both the association between physical activity and loneliness and the association between loneliness and parasocial relationships, with these associations being more pronounced among female adolescents. Network analysis further identified bridging connections between real-life relational deficits, such as feeling neglected and lacking companionship, and emotional involvement with virtual idols, such as caring about the life of a virtual idol. DISCUSSION: The findings suggest that physical activity may be associated with weaker parasocial relationships with virtual idols not only through time occupation or attention diversion, but also through lower loneliness and stronger real-life social connection. Interventions aimed at reducing excessive emotional dependence on virtual idols should therefore focus on promoting physical engagement, real-life interaction, and adolescents' sense of belonging. CI - Copyright (c) 2026 Chen, Lin, Wang, Wang and Xiang. FAU - Chen, Longjiang AU - Chen L AD - Institute of Physical Education, Yunnan Normal University, Kunming, China. FAU - Lin, Ziyang AU - Lin Z AD - School of Sport and Art, Shenzhen Technology University, Shenzhen, China. FAU - Wang, Zeyan AU - Wang Z AD - School of Physical Education, Chengdu University of Technology, Chengdu, China. FAU - Wang, Jiale AU - Wang J AD - College of Physical Education, Xinjiang Normal University, Urumqi, Xinjiang, China. FAU - Xiang, Yian AU - Xiang Y AD - Department of Rehabilitation Medicine, Lishui Municipal Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, China. LA - eng PT - Journal Article DEP - 20260630 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13365051 OTO - NOTNLM OT - adolescents OT - loneliness OT - network analysis OT - parasocial relationship OT - physical activity OT - virtual idols COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/15 06:38 MHDA- 2026/07/15 06:39 PMCR- 2026/06/30 CRDT- 2026/07/15 04:47 PHST- 2026/04/13 00:00 [received] PHST- 2026/06/07 00:00 [revised] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/07/15 06:39 [medline] PHST- 2026/07/15 06:38 [pubmed] PHST- 2026/07/15 04:47 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1854829 [doi] PST - epublish SO - Front Psychol. 2026 Jun 30;17:1854829. doi: 10.3389/fpsyg.2026.1854829. eCollection 2026. PMID- 42453080 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260904 IS - 1525-1446 (Electronic) IS - 0737-1209 (Print) IS - 0737-1209 (Linking) VI - 43 IP - 5 DP - 2026 Sep-Oct TI - The Urban-Rural Continuum and Child Health: Influence of Residential Location on Ultra-Processed Food Consumption, Physical Activity, and Metabolic Biomarkers. PG - 1180-1189 LID - 10.1111/phn.70156 [doi] AB - OBJECTIVE: This study aimed to investigate the association between residential location-urban area and urban expansion area and sociodemographic characteristics, health behaviors, and clinical-metabolic outcomes among schoolchildren aged 6 to 9 years in the municipality of Rio das Ostras, Brazil. METHODS: This was a cross-sectional study involving 420 students from public municipal schools. Sociodemographic and behavioral data were collected using validated questionnaires (QUADA-3 and QUAFDA). Anthropometric measurements, blood pressure, and biochemical analyses were conducted. Associations were assessed using Pearson's chi-square or Fisher's exact tests and logistic regression models, both crude and adjusted for age, sex, maternal and paternal education, and household income.were estimated with 95% confidence intervals (CI). FINDINGS: Children living in urban expansion areas had lower paternal education levels (p = 0.021) and were less likely to engage in active commuting to school (2.4% vs. 42.6%; p < 0.001). No significant differences were observed in excess weight, physical activity scores, or ultra-processed food consumption between the two groups. However, children from urban expansion areas showed a higher prevalence of prediabetes (OR = 0.133; 95% CI = 0.045-0.358; p < 0.001), elevated total cholesterol (OR = 0.423; p = 0.007), low HDL-c (OR = 0.324; p < 0.001), elevated LDL-c (OR = 0.304; p < 0.001), and elevated triglycerides (OR = 0.484; p = 0.029). CONCLUSIONS: Residing in urban expansion areas was associated with worse clinical-metabolic outcomes among schoolchildren, independent of nutritional status, physical activity, and ultra-processed food consumption. These findings highlight the need for intersectoral and place-based policies to promote healthier environments for children in territories undergoing urbanization. CI - (c) 2026 The Author(s). Public Health Nursing published by Wiley Periodicals LLC. FAU - Rangel, Luiz Felipe da Cruz AU - Rangel LFDC AUID- ORCID: 0000-0001-5513-0011 AD - Laboratory of Research and Innovation in Sports Science and Nutrition, Federal University of Rio de Janeiro, Macae, Brazil. AD - Josue de Castro Institute of NutritionFederal University of Rio de Janeiro, Federal University of Rio de Janeiro, Rio de Janeiro, Macae, Brazil. AD - Higher Institutes of Education of CENSA, ISECENSA, Campos dos Goytacazes, Brazil. FAU - Silva, Cynthia Goncalves AU - Silva CG AD - Laboratory of Research and Innovation in Sports Science and Nutrition, Federal University of Rio de Janeiro, Macae, Brazil. AD - Josue de Castro Institute of NutritionFederal University of Rio de Janeiro, Federal University of Rio de Janeiro, Rio de Janeiro, Macae, Brazil. FAU - de Matos, Alessandra Alegre AU - de Matos AA AUID- ORCID: 0000-0001-7938-4198 AD - Laboratory of Research and Innovation in Sports Science and Nutrition, Federal University of Rio de Janeiro, Macae, Brazil. AD - Josue de Castro Institute of NutritionFederal University of Rio de Janeiro, Federal University of Rio de Janeiro, Rio de Janeiro, Macae, Brazil. FAU - Teixeira, Francisco Martins AU - Teixeira FM AUID- ORCID: 0000-0003-0640-5570 AD - Macae Campus, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Ribeiro, Beatriz Goncalves AU - Ribeiro BG AD - Laboratory of Research and Innovation in Sports Science and Nutrition, Federal University of Rio de Janeiro, Macae, Brazil. AD - Josue de Castro Institute of NutritionFederal University of Rio de Janeiro, Federal University of Rio de Janeiro, Rio de Janeiro, Macae, Brazil. AD - Macae Campus, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. LA - eng PT - Journal Article PT - Review DEP - 20260715 PL - United States TA - Public Health Nurs JT - Public health nursing (Boston, Mass.) JID - 8501498 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Child MH - Male MH - Female MH - Brazil MH - Cross-Sectional Studies MH - *Urban Population/statistics & numerical data MH - *Rural Population/statistics & numerical data MH - *Exercise MH - *Child Health/statistics & numerical data MH - Biomarkers/blood/analysis MH - *Fast Foods/statistics & numerical data MH - *Residence Characteristics/statistics & numerical data MH - Health Behavior MH - Socioeconomic Factors PMC - PMC13535876 OTO - NOTNLM OT - child health OT - health inequalities OT - pediatric dyslipidemia OT - physical activity OT - ultra-processed foods OT - urbanization EDAT- 2026/07/15 06:37 MHDA- 2026/09/02 11:39 PMCR- 2026/09/02 CRDT- 2026/07/15 04:42 PHST- 2025/11/05 00:00 [revised] PHST- 2025/09/03 00:00 [received] PHST- 2026/06/25 00:00 [accepted] PHST- 2026/09/02 11:39 [medline] PHST- 2026/07/15 06:37 [pubmed] PHST- 2026/07/15 04:42 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - PHN70156 [pii] AID - 10.1111/phn.70156 [doi] PST - ppublish SO - Public Health Nurs. 2026 Sep-Oct;43(5):1180-1189. doi: 10.1111/phn.70156. Epub 2026 Jul 15. PMID- 42452888 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260828 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 3 DP - 2026 Jul TI - A Growing Problem: Increases in Child-Appealing Marketing on Infant and Young Children's Foods in Australia (2015 vs 2024). PG - e70226 LID - 10.1111/mcn.70226 [doi] LID - e70226 AB - Commercial foods for infants and young children are widely available and often introduced early, including before 6 months, raising concerns about their often high levels of sugar and sodium, limited micronutrient content, and sweet flavours that may shape future taste preferences. Product packaging further influences caregiver choices through child-appealing images and claims. This study examined changes in child-appealing marketing appearing on packaged commercial infant and young children's foods available in Australia in 2015 (n = 311) and 2024 (n = 298). Products were coded using a validated framework comprising 11 core techniques (child-targeted, e.g., bright colours, cartoon characters, fun themes) and 9 broad techniques (caregiver-targeted, e.g., nutrition/health, texture claims). Marketing power was calculated as the sum of techniques per product. The proportion of products featuring child-appealing marketing increased from 73.0% in 2015 to 89.9% in 2024, with significant increases in appeals to fun (48.2% to 79.2%), branded characters (33.8% to 62.4%), and child-appealing visuals on the package (60.5% to 72.5%). Claims regarding texture were high in both years (99.7% in 2015 and 100.0% in 2024), and there was a notable growth in messages promoting value, convenience, or sustainability (from 50.2% to 62.1%). Marketing power scores rose significantly over time, indicating an intensification of persuasive techniques on packaging. These findings highlight systemic commercial strategies that promote nutritionally poor foods to infants, young children and caregivers, undermining public health efforts. Stronger, government-led regulation is urgently needed to address the widespread use of both child-targeted and caregiver-targeted marketing on commercial foods for infants and young children. CI - (c) 2026 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Arfines, Prisca Petty AU - Arfines PP AUID- ORCID: 0000-0002-5118-7536 AD - Food Policy Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia. FAU - Coyle, Daisy AU - Coyle D AUID- ORCID: 0000-0001-8904-0671 AD - Food Policy Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia. FAU - Barrett, Eden AU - Barrett E AD - Food Policy Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia. FAU - McCann, Jennifer AU - McCann J AUID- ORCID: 0000-0002-8940-978X AD - Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia. FAU - Dunford, Elizabeth AU - Dunford E AD - Food Policy Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia. AD - Department of Nutrition, Gillings Global School of Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Jones, Alexandra AU - Jones A AUID- ORCID: 0000-0001-5039-144X AD - Food Policy Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - Australia MH - Infant MH - *Infant Food MH - *Marketing/trends/methods MH - *Food Preferences MH - Child, Preschool MH - *Food Labeling MH - Food Packaging MH - Nutritive Value MH - Female MH - *Consumer Behavior PMC - PMC13369571 OTO - NOTNLM OT - food analysis OT - food labelling OT - food packaging OT - infant food OT - marketing OT - nutrition labelling OT - processed food COIS- The authors declare no conflicts of interest. EDAT- 2026/07/15 06:34 MHDA- 2026/07/15 12:36 PMCR- 2026/07/14 CRDT- 2026/07/15 02:04 PHST- 2026/04/13 00:00 [revised] PHST- 2026/01/22 00:00 [received] PHST- 2026/06/13 00:00 [accepted] PHST- 2026/07/15 12:36 [medline] PHST- 2026/07/15 06:34 [pubmed] PHST- 2026/07/15 02:04 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - MCN70226 [pii] AID - 10.1111/mcn.70226 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Jul;22(3):e70226. doi: 10.1111/mcn.70226. PMID- 42451177 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 13 DP - 2026 Jul 4 TI - Trans Fatty Acids Content in Breast Milk as a Marker of Their Short-Term Intake Within the Breastfeeding Mother's Diet: A Single-Participant Pilot Study. LID - 10.3390/nu18132177 [doi] LID - 2177 AB - Introduction: Breast milk is the best food for a growing infant during the first 6 months of life. The presence of trans fatty acids (TFAs) in breast milk can interfere with the synthesis of long-chain polyunsaturated fatty acids (LC-PUFAs), increasing the risk of developing, among other issues, asthma or atopic dermatitis. TFAs are not synthesised de novo in the human body. Their content in breast milk may be a good marker of short-term dietary intake of these compounds by breastfeeding mothers. However, the literature shows differences in the assessment of the relationship between dietary TFAs intake and TFAs content in breast milk. Furthermore, the decrease in the TFAs content in food observed recently seems to make it impossible to use Craig-Schmidt's formula to estimate the TFAs content in the diet or in breast milk. The aim of this study was to confirm the possibility of using TFAs content in breast milk as a marker of their short-term intake within the breastfeeding mother's diet, together with an attempt at preliminary quantitative determination of the relationship between these parameters. Materials: The study material was collected from a single breastfeeding mother and included 10 breast milk samples and 10 samples of daily food rations reconstructed based on the 24 h food consumption survey. Methods: The content of fatty acids, including TFAs, was determined by gas chromatography-mass spectrometry (GC-MS). Results: The TFAs content in the whole-day mother's diet and in 100 mL of breast milk ranged from 0.11 to 0.54 g/day and from 0.02 to 0.07 g, respectively. A strong statistically significant (p < 0.05) positive correlation between these parameters was found. Equations for an exploratory linear relationship between the TFAs content in a breastfeeding mother's diet and the concentration of these fatty acids in breast milk have been developed. Due to the small number of samples, these data should be interpreted very cautiously and validated in a larger cohort. Conclusions: This single-participant pilot study suggests that TFAs content in breast milk may be a marker of the dietary intake of these compounds from the previous day. It seems that the dietary habits of breastfeeding mothers of twins are a significant factor influencing the composition of breast milk and, consequently, the nutritional quality of breastfed infants. FAU - Jasinska-Melon, Edyta AU - Jasinska-Melon E AUID- ORCID: 0000-0003-1697-5462 AD - Department of Nutrition and Nutritive Value of Food, National Institute of Public Health NIH-National Research Institute, Chocimska Str. 24, 00-791 Warsaw, Poland. FAU - Mojska, Hanna AU - Mojska H AUID- ORCID: 0000-0002-4093-6159 AD - Department of Nutrition and Nutritive Value of Food, National Institute of Public Health NIH-National Research Institute, Chocimska Str. 24, 00-791 Warsaw, Poland. FAU - Bzikowska-Jura, Agnieszka AU - Bzikowska-Jura A AUID- ORCID: 0000-0001-5181-3771 AD - Department of Clinical Dietetics, Faculty of Health Sciences, Medical University of Warsaw, Ciolka Str. 27, 01-445 Warsaw, Poland. LA - eng GR - 1/FZML/2023 and S.1.FZ.2.26/National Institute of Public Health NIH-National Research Institute/ PT - Journal Article DEP - 20260704 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) RN - 0 (Trans Fatty Acids) SB - IM MH - Humans MH - *Milk, Human/chemistry MH - Female MH - Pilot Projects MH - *Breast Feeding MH - Biomarkers/analysis MH - *Trans Fatty Acids/analysis MH - *Diet MH - Adult MH - Infant PMC - PMC13363609 OTO - NOTNLM OT - GC-MS OT - a 10-day reconstructed daily diet OT - breast milk OT - breastfeeding twins OT - correlations OT - trans fatty acids COIS- The authors declare no conflict of interest. EDAT- 2026/07/15 06:35 MHDA- 2026/07/15 18:40 PMCR- 2026/07/04 CRDT- 2026/07/15 01:05 PHST- 2026/05/15 00:00 [received] PHST- 2026/06/27 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/07/15 18:40 [medline] PHST- 2026/07/15 06:35 [pubmed] PHST- 2026/07/15 01:05 [entrez] PHST- 2026/07/04 00:00 [pmc-release] AID - nu18132177 [pii] AID - nutrients-18-02177 [pii] AID - 10.3390/nu18132177 [doi] PST - epublish SO - Nutrients. 2026 Jul 4;18(13):2177. doi: 10.3390/nu18132177. PMID- 42451103 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 13 DP - 2026 Jun 27 TI - Health-Related Quality of Life in Pediatric Hepatic Glycogen Storage Disease: A Dual-Perspective Study. LID - 10.3390/nu18132099 [doi] LID - 2099 AB - Background/Objectives: Hepatic glycogen storage diseases (GSDs) are rare inherited metabolic disorders requiring lifelong nutritional management and strict metabolic control, which may adversely affect the health-related quality of life (HRQoL). This study aimed to evaluate the HRQoL in children with hepatic GSD using both child and parent reports, compare findings with normative data, and explore associations with biochemical, anthropometric, and nutritional management-related parameters. Methods: The study included 23 children with hepatic GSD and their parents. HRQoL was assessed using the Pediatric Quality of Life Inventory (PedsQL) Generic Core Scale. Child and parent reports were compared with normative data for healthy and chronically ill children. Agreement between child and parent reports was evaluated with intraclass correlation coefficients, and exploratory associations between variables were assessed using partial Spearman correlation analyses. Results: Total and most subscale PedsQL scores reported by both children and parents were significantly lower than those of healthy peers and children with chronic diseases (p < 0.05). Parents reported lower HRQoL scores than children, particularly in psychosocial, social, and school functioning domains, with low to moderate agreement between reports. Exploratory analyses suggested that body composition and nutritional treatment burden indicators were correlated with selected HRQoL domains. Conclusions: Children with hepatic GSD experience impaired HRQoL from both child and parent perspectives. Integrating HRQoL assessment into routine clinical and nutritional follow-up may help identify unmet psychosocial and dietary support needs and support more individualized nutritional management in children with hepatic GSD. FAU - Aydin, Oznur AU - Aydin O AUID- ORCID: 0000-0001-8463-6660 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Ankara 06100, Turkiye. FAU - Dagdelen, Selcuk AU - Dagdelen S AUID- ORCID: 0000-0002-0513-1750 AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara 06230, Turkiye. FAU - Ozen, Hasan AU - Ozen H AUID- ORCID: 0000-0002-9063-3893 AD - Division of Pediatrics, Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara 06230, Turkiye. FAU - Gokmen-Ozel, Hulya AU - Gokmen-Ozel H AUID- ORCID: 0000-0002-8282-6468 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Ankara 06100, Turkiye. LA - eng GR - 2211/A/Turkiye Bilimsel ve Teknolojik Arastirma Kurumu/ PT - Journal Article DEP - 20260627 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - Hepatorenal form of glycogen storage disease SB - IM MH - Humans MH - *Quality of Life MH - Male MH - Female MH - Child MH - Parents/psychology MH - Child, Preschool MH - *Glycogen Storage Disease/psychology MH - Adolescent MH - Nutritional Status MH - *Glycogen Storage Disease Type I/psychology PMC - PMC13364485 OTO - NOTNLM OT - body composition OT - nutritional management OT - parent-proxy report OT - pediatric quality of life inventory OT - uncooked cornstarch COIS- The authors declare no conflicts of interest. EDAT- 2026/07/15 06:36 MHDA- 2026/07/15 18:42 PMCR- 2026/06/27 CRDT- 2026/07/15 01:05 PHST- 2026/05/22 00:00 [received] PHST- 2026/06/21 00:00 [revised] PHST- 2026/06/25 00:00 [accepted] PHST- 2026/07/15 18:42 [medline] PHST- 2026/07/15 06:36 [pubmed] PHST- 2026/07/15 01:05 [entrez] PHST- 2026/06/27 00:00 [pmc-release] AID - nu18132099 [pii] AID - nutrients-18-02099 [pii] AID - 10.3390/nu18132099 [doi] PST - epublish SO - Nutrients. 2026 Jun 27;18(13):2099. doi: 10.3390/nu18132099. PMID- 42451050 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 13 DP - 2026 Jun 23 TI - Extending the Validity of the Feeding Practices and Structure Questionnaire Solid Feeding Version (FPSQ-S) to Mothers and Fathers Living with Socioeconomic Disadvantage. LID - 10.3390/nu18132046 [doi] LID - 2046 AB - Background/Objective: Parental feeding practices play an important role in shaping children's dietary intake, eating behaviours, and long-term health outcomes. Although several questionnaires assess feeding practices, few have been validated among socioeconomically disadvantaged populations, despite these groups being disproportionately affected by food insecurity and diet-related health inequities. This study assessed the structural validity and internal consistency of the Feeding Practices and Structure Questionnaire-Solid Feeding version (FPSQ-S)-among socioeconomically disadvantaged mothers and fathers of young children. Methods: Two cross-sectional online surveys were conducted with 178 mothers and 94 fathers of children aged 5-35 months living in disadvantaged households. Confirmatory factor analysis was used to examine the structural validity of the FPSQ-S. Internal consistency was assessed using Cronbach's alpha and Hancock's H coefficients. Results: The original six-factor FPSQ-S structure was retained and demonstrated acceptable overall model fit in this disadvantaged sample (CFI = 0.846, TLI = 0.821, RMSEA = 0.070). Internal consistency ranged from acceptable to excellent across subscales (Cronbach's alpha = 0.63-0.93; Hancock's H = 0.64-0.93). Most items loaded satisfactorily onto their intended constructs; however, two items within the Feeding on Demand construct demonstrated weak factor loadings, and this construct showed lower reliability than the remaining subscales Conclusions: This is the first study to evaluate the FPSQ-S among socioeconomically disadvantaged mothers and fathers of children aged 5-35 months. The FPSQ-S demonstrated acceptable structural validity and reliability. While the six-factor structure was largely supported, further refinement of the Feeding on Demand construct and additional psychometric evaluation are warranted. FAU - Nambiar, Smita AU - Nambiar S AUID- ORCID: 0000-0002-0626-1119 AD - School of Exercise and Nutrition Sciences, Faculty of Health, Queensland University of Technology, Victoria Park Road, Kelvin Grove, QLD 4059, Australia. AD - Centre for Childhood Nutrition Research, Faculty of Health, Queensland University of Technology, 62 Graham Street, South Brisbane, QLD 4101, Australia. FAU - So, Jeffrey T H AU - So JTH AUID- ORCID: 0000-0003-0516-9609 AD - School of Exercise and Nutrition Sciences, Faculty of Health, Queensland University of Technology, Victoria Park Road, Kelvin Grove, QLD 4059, Australia. AD - Centre for Childhood Nutrition Research, Faculty of Health, Queensland University of Technology, 62 Graham Street, South Brisbane, QLD 4101, Australia. AD - School of Health, University of the Sunshine Coast, Sippy Downs, QLD 4556, Australia. FAU - Jansen, Elena AU - Jansen E AUID- ORCID: 0000-0002-6051-4148 AD - Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. LA - eng GR - WCCNR03/Children's Hospital Foundation/ PT - Journal Article PT - Validation Study DEP - 20260623 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Female MH - *Feeding Behavior MH - Child, Preschool MH - Cross-Sectional Studies MH - Infant MH - *Mothers MH - *Fathers MH - Surveys and Questionnaires/standards MH - Adult MH - Reproducibility of Results MH - Socioeconomic Factors MH - Factor Analysis, Statistical MH - *Vulnerable Populations MH - Psychometrics MH - Low Socioeconomic Status PMC - PMC13362640 OTO - NOTNLM OT - confirmatory factor analysis OT - fathers OT - feeding practices questionnaire OT - infants and children OT - mothers OT - responsive feeding OT - socioeconomically disadvantage COIS- The authors declare no conflicts of interest. EDAT- 2026/07/15 06:37 MHDA- 2026/07/15 12:36 PMCR- 2026/06/23 CRDT- 2026/07/15 01:05 PHST- 2026/05/08 00:00 [received] PHST- 2026/06/12 00:00 [revised] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/07/15 12:36 [medline] PHST- 2026/07/15 06:37 [pubmed] PHST- 2026/07/15 01:05 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - nu18132046 [pii] AID - nutrients-18-02046 [pii] AID - 10.3390/nu18132046 [doi] PST - epublish SO - Nutrients. 2026 Jun 23;18(13):2046. doi: 10.3390/nu18132046. PMID- 42450823 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260715 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 13 DP - 2026 Jun 23 TI - Physical Activity, Physical Fitness, and Motor Competence in Children Aged 5-10 Years-A Systematic Review. LID - 10.3390/healthcare14131813 [doi] LID - 1813 AB - BACKGROUND: Motor competence (MC), physical activity (PA), and physical fitness (PF) are interrelated components of child development, yet evidence on the MC-PF-PA triad in middle childhood remains inconsistent due to methodological heterogeneity. OBJECTIVE: To synthesise associations between MC, PF, and PA in children aged 5-10 years (2020-2025) and to appraise methodological quality and certainty. METHODS: A PRISMA 2020-compliant systematic review (PROSPERO: CRD42024617560) searched six databases (PubMed, Scopus, Web of Science, SportDiscus, SciELO, PsycINFO) from January 2020 to April 2025, updated November 2025. Eligible observational studies in English reported quantitative associations between >/=2 constructs in 5-10-year-olds using validated instruments. Risk of bias was appraised in duplicate with JBI checklists. Quantitative pooling was unfeasible under a pre-specified pooling matrix; associations were synthesised narratively and certainty rated using a GRADE-style framework. RESULTS: Thirteen studies (n = 43-1064; 11 cross-sectional, 2 longitudinal) were included; six were low, five moderate, and two high risk of bias. MC-PA was predominantly positive, especially with objective instruments; MC-PF was consistently positive; PF-PA was less consistent but trended positive longitudinally. Mediation/moderation analyses (k = 3) supported roles for perceived competence, self-efficacy, and PF. Null/negative findings clustered among subjective PA measures and higher risk of bias. GRADE certainty was low-to-moderate. CONCLUSIONS: MC, PF, and PA are interconnected in middle childhood, but cross-sectional predominance and instrument heterogeneity preclude causal inference; findings are provisional and should drive longitudinal, methodologically standardised research. FAU - Rosa, Paulino Gomes AU - Rosa PG AUID- ORCID: 0000-0002-8103-4522 AD - ESECS, Polytechnique University of Leiria, 2411-901 Leiria, Portugal. AD - SPRINT-Sport Physical Activity and Health Research & Innovation Center, 6000-084 Castelo Branco, Portugal. AD - Portugal Life Quality Research Centre (CIEQV), 2040-413 Rio Maior, Portugal. FAU - Furtado, Guilherme Eustaquio AU - Furtado GE AUID- ORCID: 0000-0001-8327-1567 AD - SPRINT-Sport Physical Activity and Health Research & INnovation Center, Polytechnic University of Coimbra, Rua Dom Joao III-Solum, 3030-329 Coimbra, Portugal. AD - Applied Research Institute, Polytechnic Institute of Coimbra, Rua da Misericordia, Lagar dos Corticos-S. Martinho do Bispo, 3045-093 Coimbra, Portugal. FAU - Jacinto, Miguel AU - Jacinto M AUID- ORCID: 0000-0002-1727-3537 AD - ESECS, Polytechnique University of Leiria, 2411-901 Leiria, Portugal. AD - Research Centre in Sports Sciences, Health Sciences and Human Development (CIDESD), 6201-001 Covilha, Portugal. FAU - Ibanez, Sergio Jose AU - Ibanez SJ AUID- ORCID: 0000-0001-6009-4086 AD - Facultad de Ciencias del Deporte, Grupo de Optimizacion del Entrenamiento y Rendimiento Deportivo, Universidad de Extremadura, 10003 Caceres, Spain. FAU - Serrano, Joao AU - Serrano J AUID- ORCID: 0000-0001-5112-4984 AD - SPRINT-Sport Physical Activity and Health Research & Innovation Center, 6000-084 Castelo Branco, Portugal. AD - Department of Sports and Well-Being, Politecnic University of Castelo Branco, 6000-266 Castelo Branco, Portugal. LA - eng PT - Journal Article PT - Review DEP - 20260623 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13361801 OTO - NOTNLM OT - child health promotion OT - fundamental movement skills OT - motor skill development OT - movement behaviours OT - physical literacy OT - school-based interventions COIS- The authors declare that they have no competing interests. EDAT- 2026/07/15 10:10 MHDA- 2026/07/15 10:11 PMCR- 2026/06/23 CRDT- 2026/07/15 01:04 PHST- 2026/02/26 00:00 [received] PHST- 2026/05/11 00:00 [revised] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/07/15 10:11 [medline] PHST- 2026/07/15 10:10 [pubmed] PHST- 2026/07/15 01:04 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - healthcare14131813 [pii] AID - healthcare-14-01813 [pii] AID - 10.3390/healthcare14131813 [doi] PST - epublish SO - Healthcare (Basel). 2026 Jun 23;14(13):1813. doi: 10.3390/healthcare14131813. PMID- 42449095 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261010 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Jul 14 TI - A cross-sectional study of the associations between intuitive eating and maladaptive eating behaviors in Brazilian University students. LID - 10.1007/s40519-026-01888-8 [doi] LID - 85 AB - PURPOSE: To investigate the relationships between Intuitive Eating and maladaptive eating behaviors among Brazilian university students. METHODS: A cross-sectional quantitative study was conducted among technical, undergraduate, and postgraduate students aged 18 years or above, between 2020 and 2021. Participants completed an online survey comprising sociodemographic questions, the Intuitive Eating Scale-2 (IES-2), and the Three-Factor Eating Questionnaire-Revised 21 (TFEQ-R21), both validated for the Brazilian population. Spearman's correlation and MANCOVA tests were used to assess associations between study variables. RESULTS: The study included 1,237 participants (82.6% females) with a mean age of 26.3 (SD = 8.0) years. Intuitive Eating and its domains were negatively associated with Cognitive Restraint, Emotional Eating and Uncontrolled Eating. In the MANCOVA model, the Unconditional Permission to Eat subscale (IES-2) explained a large proportion of variance in Cognitive Restraint (eta2p = .314), and the Eating for Physical Rather than Emotional Reasons subscale (IES-2) explained a large proportion of variance in Emotional Eating (eta2p = .587). CONCLUSION: Intuitive eating and its domains were negatively associated with maladaptive eating behaviors among Brazilian university students, particularly Emotional Eating and Cognitive Restraint, with Eating for Physical Rather than Emotional Reasons and Unconditional Permission to Eat showing the strongest relationships. LEVEL OF EVIDENCE: Level 4-Cross-sectional study. CI - (c) 2026. The Author(s). FAU - Yavorivski, Andressa AU - Yavorivski A AD - School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil. FAU - Ruiz, Ana Correa AU - Ruiz AC AD - School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil. FAU - Poinhos, Rui AU - Poinhos R AUID- ORCID: 0000-0002-9177-6423 AD - Faculty of Nutrition and Food Sciences, University of Porto, Porto, Portugal. ruipoinhos@fcna.up.pt. AD - Department of Biology and Environment, School of Life and Environmental Sciences, University of Tras-os-Montes e Alto Douro, Vila Real, Portugal. ruipoinhos@fcna.up.pt. FAU - Feoli, Ana Maria Pandolfo AU - Feoli AMP AD - Postgraduate Program in Psychology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil. LA - eng PT - Journal Article DEP - 20260714 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Brazil MH - Adult MH - Male MH - *Feeding Behavior/psychology MH - Young Adult MH - *Students/psychology MH - Universities MH - Emotional Eating MH - Surveys and Questionnaires MH - *Feeding and Eating Disorders/psychology MH - Adolescent MH - Emotions/physiology MH - *Eating/psychology MH - *Intuition/physiology PMC - PMC13645931 OTO - NOTNLM OT - Disordered eating OT - Eating behavior OT - Emotional eating OT - Intuitive eating OT - Uncontrolled eating COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/07/15 00:35 MHDA- 2026/10/08 05:31 PMCR- 2026/07/14 CRDT- 2026/07/14 23:35 PHST- 2024/09/11 00:00 [received] PHST- 2026/07/05 00:00 [accepted] PHST- 2026/10/08 05:31 [medline] PHST- 2026/07/15 00:35 [pubmed] PHST- 2026/07/14 23:35 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - 10.1007/s40519-026-01888-8 [pii] AID - 1888 [pii] AID - 10.1007/s40519-026-01888-8 [doi] PST - epublish SO - Eat Weight Disord. 2026 Jul 14;31(1):85. doi: 10.1007/s40519-026-01888-8. PMID- 42449006 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2509-8020 (Electronic) IS - 2509-8020 (Linking) VI - 10 IP - 1 DP - 2026 Jul 14 TI - Linguistical and psychometric validation of the MIND Youth Questionnaire (My-Q) in Swedish. LID - 10.1186/s41687-026-01148-4 [doi] LID - 121 AB - BACKGROUND: The Mind Youth Questionnaire is a multidimensional health-related quality-of-life questionnaire designed for pediatric diabetes care and exists in Dutch, English, and Spanish. METHODS: The aim of this study was to linguistically and psychometrically validate the Mind Youth Questionnaire (My-Q) for Swedish-speaking youths with type 1 diabetes. The linguistic process of the Dutch version followed ISPOR s guidelines. For face validity, youths with type 1 diabetes and diabetes nurses were interviewed. Three stigma items were included. The final Swedish My-Q consists of 38 items. A total of 166 youths (10-19 years) completed the My-Q and Pediatric Quality of Life Inventory diabetes module. A 2nd -order confirmatory factor analysis was conducted using the nine-factor Dutch and five-factor Spanish versions. RESULTS: The 2nd -order nine-factor solution (social impact, parents, diabetes control perceptions, responsibilities, worries, treatment satisfaction, body image and eating behavior, stigma, and mood) showed adequate fit: chi2(551) = 828.36 (p < .01), Comparative Fit Index (CFI) = 0.90, Root Mean Square Error of Approximation (RMSEA) = 0.05 [0.05,0.06], Standardized Root Mean Square Residual (SRMR) = 0.08. The nine-factor solution and grouping of the items followed a clear rationale. The reliability coefficients of the total scale were adequate, alpha = 0.86, Omega = 0.90, and Omega for all the factors ranged from 0.49 to 0.88. The relationships between My-Q factors and sociodemographic variables revealed that boys had better health-related quality of life than girls. Younger youths reported better health-related quality of life in terms of body image and eating behavior (p=.005). Concurrent validity was confirmed, as all the factors were positively related to all the Pediatric Quality of Life Inventory diabetes module factors. A negative correlation was found between the level of glycated hemoglobin and the My-Q score (r=-.258, p < .001). CONCLUSION: The Swedish My-Q has adequate psychometric properties and can be used in research and for routine psychosocial assessment. CI - (c) 2026. The Author(s). FAU - Brorsson, Anna Lena AU - Brorsson AL AUID- ORCID: 0000-0002-8136-6340 AD - Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden. anna-lena.brorsson@ki.se. AD - Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden. anna-lena.brorsson@ki.se. FAU - Rudilla, David AU - Rudilla D AUID- ORCID: 0000-0002-6042-4724 AD - Pulmonology, Air Liquide Healthcare, Hospital Universitario de la Princesa, Madrid, Spain. FAU - Kleijberg, Max AU - Kleijberg M AD - Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. AD - Department of Health Sciences, Innovation and Design, Malardalen University, Eskilstuna, Sweden. FAU - deWit, Maartje AU - deWit M AD - Medical Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands. FAU - Lundberg, Elena AU - Lundberg E AD - Department of Pediatrics, Institution of Clinical Science, Umea University, Umea, Sweden. FAU - Lindholm-Olinder, Anna AU - Lindholm-Olinder A AUID- ORCID: 0000-0002-8422-2457 AD - Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden. AD - Sachs Children and Youth Hospital, Stockholm South General Hospital, Stockholm, Sweden. LA - eng PT - Journal Article PT - Validation Study DEP - 20260714 PL - Germany TA - J Patient Rep Outcomes JT - Journal of patient-reported outcomes JID - 101722688 SB - IM MH - Humans MH - Male MH - Female MH - *Diabetes Mellitus, Type 1/psychology/therapy MH - Adolescent MH - Psychometrics MH - Child MH - *Quality of Life/psychology MH - Sweden MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Young Adult MH - Linguistics MH - Body Image MH - Factor Analysis, Statistical PMC - PMC13373108 OTO - NOTNLM OT - Questionnaire OT - Type 1 diabetes OT - Validation OT - Youth COIS- Declarations. Ethics approval and consent to participate: The Swedish Ethical Review Authority approved this study (no: 2022-03838-01 and 2022-05738-02), which was conducted in accordance with the Declaration of Helsinki [34]. Consent for publication: Before inclusion, participants and their parents received oral and written information. The participants signed informed consent forms. In accordance with Swedish regulations, the legal guardians of participants under 15 years of age also signed an informed consent form. Competing interests: The authors declare no competing interests. EDAT- 2026/07/15 00:35 MHDA- 2026/07/15 12:37 PMCR- 2026/07/14 CRDT- 2026/07/14 23:32 PHST- 2026/02/04 00:00 [received] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/07/15 12:37 [medline] PHST- 2026/07/15 00:35 [pubmed] PHST- 2026/07/14 23:32 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - 10.1186/s41687-026-01148-4 [pii] AID - 1148 [pii] AID - 10.1186/s41687-026-01148-4 [doi] PST - epublish SO - J Patient Rep Outcomes. 2026 Jul 14;10(1):121. doi: 10.1186/s41687-026-01148-4. PMID- 42448911 OWN - NLM STAT- Publisher LR - 20260714 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Jul 14 TI - Assessing infants' sleep in the home setting: designing rational study approaches. LID - 10.1038/s41390-026-05273-0 [doi] AB - The methods used for assessing infants' sleep vary widely, and the insights provided by each method are not necessarily interchangeable. Direct physiological measurements are often performed in hospital environments with extensive and controllable instrumentation, whereas at-home assessments have been based on parental questionnaires and diaries or actigraphy measurements. There is a rising need for the establishment of objective at-home methods to improve ecological validity in assessing infant sleep. Here, we review how specific research questions can be aligned with at-home assessment methods, ranging from indirect parental interviews to direct modern measures with unobtrusive sensors (wearables, in-bed sensors, video), and their integrated machine learning -based analytics. We discuss the nature of information available from each method in relation to the physiological or behavioural sleep phenomena. The currently available methods may support disruptive science, including globally harmonized and scaled-up studies across cultures and geographic locations, including fully decentralized developmental research and sleep-focused health care. IMPACT: The paper raises the practical and scientific need to study infant sleep using methods that are both objective and ecologically valid, thereby supporting the use of direct at-home measurements. The paper emphasizes the multifaceted nature of infant sleep, which precludes its assessment as a solitary entity and calls for clear research questions to identify measurable phenomena in sleep-related physiology or behavior Presently available research methods for at-home studies are described and compared in relation to their information content, practical utility and caveats Various analytic results and sleep metrics are described in relation to the underlying sleep physiology or behavior. The overall message emphasizes the need to establish a solid end-to-end waterfall framework in infant sleep research, spanning study questions, sleep phenomena, recording methods, and data analytics. CI - (c) 2026. The Author(s). FAU - Vanhatalo, Sampsa AU - Vanhatalo S AD - Department of Physiology, University of Helsinki, Helsinki, Finland. Sampsa.vanhatalo@helsinki.fi. AD - Department of Clinical Neurophysiology, BABA Center, Paediatric Research Center, New Children's Hospital, Helsinki University Hospital, Helsinki, Finland. Sampsa.vanhatalo@helsinki.fi. FAU - Austin, Topun AU - Austin T AD - NeoLAB, Evelyn Perinatal Imaging Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. FAU - Boylan, Geraldine B AU - Boylan GB AD - INFANT Research Centre, University College Cork, Cork, Ireland. FAU - Blumberg, Mark AU - Blumberg M AD - Department of Psychological&Brain Sciences, University of Iowa, Iowa City, IA, USA. FAU - de Vos, Maarten AU - de Vos M AD - Department of Electrical Engineering (ESAT), STADIUS, KU Leuven, Leuven, Belgium. FAU - Airaksinen, Manu AU - Airaksinen M AD - Department of Physiology, University of Helsinki, Helsinki, Finland. AD - Department of Clinical Neurophysiology, BABA Center, Paediatric Research Center, New Children's Hospital, Helsinki University Hospital, Helsinki, Finland. FAU - de Sena, Sofie AU - de Sena S AD - Department of Physiology, University of Helsinki, Helsinki, Finland. AD - Department of Clinical Neurophysiology, BABA Center, Paediatric Research Center, New Children's Hospital, Helsinki University Hospital, Helsinki, Finland. FAU - Shellhaas, Renee A AU - Shellhaas RA AD - Department of Neurology, Washington University in St Louis School of Medicine, St Louis, MO, USA. FAU - Dudink, Jeroen AU - Dudink J AD - Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands. LA - eng PT - Journal Article PT - Review DEP - 20260714 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/07/15 00:35 MHDA- 2026/07/15 00:35 CRDT- 2026/07/14 23:29 PHST- 2026/03/08 00:00 [received] PHST- 2026/06/14 00:00 [accepted] PHST- 2026/06/09 00:00 [revised] PHST- 2026/07/15 00:35 [medline] PHST- 2026/07/15 00:35 [pubmed] PHST- 2026/07/14 23:29 [entrez] AID - 10.1038/s41390-026-05273-0 [pii] AID - 10.1038/s41390-026-05273-0 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Jul 14. doi: 10.1038/s41390-026-05273-0. PMID- 42447299 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260807 IS - 1944-0057 (Electronic) IS - 1944-0057 (Linking) VI - 43 IP - 8 DP - 2026 Aug TI - A multi-tiered approach for human health risk assessment of pesticide residues in green peppers using Monte Carlo simulation. PG - 1182-1195 LID - 10.1080/19440049.2026.2691366 [doi] AB - Exposure to pesticide residues in vegetables remains a major concern for human health. This study proposes a robust, multi-tiered human health risk assessment framework to support food safety decision-making, using sweet green peppers as a case study. The approach integrates regulatory compliance assessment (Tier 1), deterministic evaluation (Tier 2), and probabilistic modelling (Tier 3). Pesticide residues from 80 samples were quantified using a QuEChERS UPLC-MS/MS method validated according to SANTE/11312/2021 guidelines. Residues were detected in 37.5% of samples, with 13 active substances quantified above the limit of quantification, and only 3.75% exceeding EU maximum residue limits, indicating high compliance. The deterministic assessment (Tier 2), based on a conservative intake-to-body weight ratio and mean concentrations of quantified residues, resulted in cumulative hazard index (HI) values of 0.044 for adults and 0.046 for children/adolescents. The inclusion of non-quantified compounds using the Middle-Bound approach (LOQ/2) increased the cumulative HI values to 0.067 for adults and 0.071 for children/adolescents. In contrast, the probabilistic risk assessment (Tier 3), based on fitted distributions of residue concentrations and dietary intake, yielded cumulative risk estimates at upper exposure percentiles (p90-p99), ranging from 0.0006 to 0.0045 for adults and from 0.0011 to 0.0057 for children/adolescents. These findings highlight the added value of probabilistic approaches for characterising dietary risk by incorporating exposure variability and reducing uncertainty. In particular, Tier 3 enables a more realistic estimation of exposure based on limited quantitative data and allows the integration and interpretation of values below the LOQ, thereby contributing to a more robust risk assessment. FAU - Boudriiya, Imane AU - Boudriiya I AD - Biotechnology and Biomolecular Engineering Research Team, Faculty of Sciences and Technologies of Tangier, University of Abdelmalek Essaadi, Tangier, Morocco. AD - Regional Laboratory of Analysis and Research, National Office of Food Safety (ONSSA), Tangier, Morocco. FAU - Marti, Vicenc AU - Marti V AD - Chemical Engineering Department, Escola d'Enginyeria de Barcelona Est (EEBE), Universitat Politecnica de Catalunya (UPC)-BarcelonaTECH and Barcelona Research Center for Multiscale Science and Engineering (CCEM), Barcelona, Spain. FAU - Kounnoun, Ayoub AU - Kounnoun A AD - Faculty, of Medical Sciences, UM6P Hospitals, Mohammed VI Polytechnic University, Benguerir, Morocco. FAU - El Maadoudi, Mohammed AU - El Maadoudi M AD - Regional Laboratory of Analysis and Research, National Office of Food Safety (ONSSA), Tangier, Morocco. FAU - Alahlah, Naoual AU - Alahlah N AD - Regional Laboratory of Analysis and Research, National Office of Food Safety (ONSSA), Tangier, Morocco. FAU - Ait Lamine, Naima AU - Ait Lamine N AD - Regional Laboratory of Analysis and Research, National Office of Food Safety (ONSSA), Tangier, Morocco. FAU - Laglaoui, Amin AU - Laglaoui A AD - Biotechnology and Biomolecular Engineering Research Team, Faculty of Sciences and Technologies of Tangier, University of Abdelmalek Essaadi, Tangier, Morocco. FAU - Hassani Zerrouk, Mounir AU - Hassani Zerrouk M AD - Biotechnology and Biomolecular Engineering Research Team, Faculty of Sciences and Technologies of Tangier, University of Abdelmalek Essaadi, Tangier, Morocco. LA - eng PT - Journal Article DEP - 20260714 PL - England TA - Food Addit Contam Part A Chem Anal Control Expo Risk Assess JT - Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment JID - 101485040 RN - 0 (Pesticide Residues) SB - IM MH - Risk Assessment MH - Humans MH - *Pesticide Residues/analysis MH - *Capsicum/chemistry MH - *Food Contamination/analysis MH - *Monte Carlo Method MH - Tandem Mass Spectrometry OTO - NOTNLM OT - QuEChERS OT - UPLC-MS/MS OT - dietary exposure OT - hazard index OT - hazard quotient OT - probabilistic exposure modelling EDAT- 2026/07/14 18:43 MHDA- 2026/08/07 12:39 CRDT- 2026/07/14 15:12 PHST- 2026/08/07 12:39 [medline] PHST- 2026/07/14 18:43 [pubmed] PHST- 2026/07/14 15:12 [entrez] AID - 10.1080/19440049.2026.2691366 [doi] PST - ppublish SO - Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2026 Aug;43(8):1182-1195. doi: 10.1080/19440049.2026.2691366. Epub 2026 Jul 14. PMID- 42446071 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261014 IS - 1099-0968 (Electronic) IS - 1072-4133 (Print) IS - 1072-4133 (Linking) VI - 34 IP - 6 DP - 2026 Nov TI - Weight Bias Internalisation and Health-Related Quality of Life in Adolescents: What Role Do Family Meals Play? PG - 1648-1659 LID - 10.1002/erv.70142 [doi] AB - OBJECTIVE: Weight bias internalisation (WBI) has been associated with poorer health-related quality of life (HRQoL), however, evidence in community-based adolescent samples remains scarce. Family meals have shown protective effects on adolescent health, yet their role in the relationship between WBI and HRQoL has not yet been explored. This study investigated associations between WBI, HRQoL, and family meals in Spanish adolescents. METHOD: We conducted a cross-sectional study with a representative sample of 1016 adolescents aged 11-16 from Terrassa, Spain (random multistage cluster sampling). Validated instruments were used to assess WBI (WBIS-M), HRQoL (KIDSCREEN-27), and family dinner quality and frequency. Anthropometric data were objectively measured. Adjusted regression models were conducted. RESULTS: Lower WBI and a higher frequency and quality of family dinners were associated with higher HRQoL scores across KIDSCREEN-27 domains. Further analyses revealed that family dinners moderated the effect of WBI on two HRQoL factors, attenuating its negative impact. However, this moderating impact became substantially weaker at higher levels of WBI. CONCLUSIONS: This study of Spanish adolescents is the first to show a negative association between WBI and HRQoL and that this relationship is moderated by the frequency and quality of shared family meals, suggesting that supportive family environments can buffer WBI's negative impact, although this protective role is attenuated at the highest levels of WBI, highlighting the vital need for early prevention, and warranting further investigation. CI - (c) 2026 Beat Eating Disorders and John Wiley & Sons Ltd. All rights reserved, including rights for text and data mining and training of artificial intelligence technologies or similar technologies. FAU - Broto-Puig, Jaume AU - Broto-Puig J AD - Faculty of Health Sciences, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. FAU - Latorre-Millan, Miriam AU - Latorre-Millan M AD - Faculty of Health Sciences, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. AD - Miguel Servet University Hospital, Institute for Health Research Aragon (IIS Aragon), Zaragoza, Spain. AD - Department of Pharmacy and Nutrition, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Villaviciosa de Odon, Madrid, Spain. FAU - Penelo, Eva AU - Penelo E AD - Departament de Psicobiologia i de Metodologia de les Ciencies de la Salut, Universitat Autonoma de Barcelona, Barcelona, Spain. FAU - Bach-Faig, Anna AU - Bach-Faig A AD - NUTRALiSS Research Group, Faculty of Health Sciences, Open University of Catalonia (UOC), Barcelona, Spain. FAU - Sanchez-Carracedo, David AU - Sanchez-Carracedo D AD - Department of Clinical and Health Psychology, Universitat Autonoma de Barcelona, Barcelona, Spain. LA - eng GR - RTI2018-099293-B-I00/Spanish Ministry of Science and Innovation/ GR - PID2022-138977OB-I00/Spanish Ministry of Science and Innovation/ PT - Journal Article DEP - 20260714 PL - England TA - Eur Eat Disord Rev JT - European eating disorders review : the journal of the Eating Disorders Association JID - 9436977 SB - IM MH - Humans MH - Adolescent MH - *Quality of Life/psychology MH - Female MH - Cross-Sectional Studies MH - Child MH - Spain MH - Male MH - *Meals/psychology MH - *Body Weight MH - *Family/psychology MH - *Feeding Behavior/psychology MH - *Body Image/psychology PMC - PMC13656762 OTO - NOTNLM OT - family dinner index OT - family meals OT - quality of life OT - weight bias internalisation OT - weight stigma COIS- The authors declare no conflicts of interest. EDAT- 2026/07/14 14:00 MHDA- 2026/10/12 11:41 PMCR- 2026/10/12 CRDT- 2026/07/14 08:03 PHST- 2026/06/09 00:00 [revised] PHST- 2026/03/09 00:00 [received] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/10/12 11:41 [medline] PHST- 2026/07/14 14:00 [pubmed] PHST- 2026/07/14 08:03 [entrez] PHST- 2026/10/12 00:00 [pmc-release] AID - ERV70142 [pii] AID - 10.1002/erv.70142 [doi] PST - ppublish SO - Eur Eat Disord Rev. 2026 Nov;34(6):1648-1659. doi: 10.1002/erv.70142. Epub 2026 Jul 14. PMID- 42445937 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260714 LR - 20260813 IS - 2055-7647 (Print) IS - 2055-7647 (Electronic) IS - 2055-7647 (Linking) VI - 12 IP - 3 DP - 2026 TI - Associations of academic performance, sports participation, disordered eating and menstrual cycle irregularities in adolescents: a population-based study. PG - e003078 LID - 10.1136/bmjsem-2025-003078 [doi] LID - e003078 AB - BACKGROUND: Regular menstruation is an important indicator of well-being in adolescent females. We aimed to assess risk factors associated with menstrual cycle irregularities in a population-based cohort of high school students. METHODS: In the fall of 2022, we recruited a cohort of 1161 first-year female students from 21 socio-economically diverse high schools in the capital region of Finland. Participants completed an online survey addressing menstruation, academic performance and sports participation and validated questionnaires (the Sick-Control-One stone-Fat-Food (SCOFF) eating disorder screening tool and School Burnout Inventory). RESULTS: Of 935 (81%) participants (mean age 16) not using hormonal preparations, 336 (37%) reported irregular menstruation. Elevated School Burnout Inventory scores (per point OR 1.03, 95% CI 1.01 to 1.05), lower body mass index (OR 1.86, 95% CI 1.12 to 3.08) and high SCOFF scores (OR 2.09, 95% CI 1.40 to 3.10) were associated with irregular menstruation. Overall physical activity levels showed no significant association with menstruation. In subgroup analysis, low body mass index and disordered eating symptoms were associated with irregular menstruation among casual exercisers whereas school burnout was associated with irregular menstruation among competitive athletes. CONCLUSION: School-related stress, eating and exercise habits should be evaluated among high school students presenting with menstrual irregularities, as these factors may be relevant in identifying adolescents at risk of more severe reproductive dysfunctions, including amenorrhoea. CI - Copyright (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Moro, Sara Maria Margareeta AU - Moro SMM AUID- ORCID: 0009-0007-7340-5817 AD - Helsinki University Hospital, New Children's Hospital, Helsinki, Finland. AD - Clinicum, University of Helsinki, Helsinki, Finland. FAU - Holopainen, Elina AU - Holopainen E AD - Clinicum, University of Helsinki, Helsinki, Finland. AD - Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland. FAU - Saari, Viivi AU - Saari V AD - Clinicum, University of Helsinki, Helsinki, Finland. AD - Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland. FAU - Kosola, Silja AU - Kosola S AD - Clinicum, University of Helsinki, Helsinki, Finland. AD - Research Services, Western Uusimaa County Wellbeing Services, Espoo, Finland. LA - eng PT - Journal Article DEP - 20260710 PL - England TA - BMJ Open Sport Exerc Med JT - BMJ open sport & exercise medicine JID - 101681007 PMC - PMC13358262 OTO - NOTNLM OT - Adolescent OT - Eating disorders OT - Menstruation OT - Physical activity COIS- None declared. EDAT- 2026/07/14 18:26 MHDA- 2026/07/14 18:27 PMCR- 2026/07/10 CRDT- 2026/07/14 06:56 PHST- 2025/11/05 00:00 [received] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/07/14 18:27 [medline] PHST- 2026/07/14 18:26 [pubmed] PHST- 2026/07/14 06:56 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - bmjsem-2025-003078 [pii] AID - 10.1136/bmjsem-2025-003078 [doi] PST - epublish SO - BMJ Open Sport Exerc Med. 2026 Jul 10;12(3):e003078. doi: 10.1136/bmjsem-2025-003078. eCollection 2026. PMID- 42445753 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1658-3175 (Electronic) IS - 0379-5284 (Print) IS - 0379-5284 (Linking) VI - 47 IP - 8 DP - 2026 Aug TI - Dietary Fat Intake and Its Influence on the Association Between Liver Fat and Brain Choline Metabolism in Young Saudi Women. PG - 1309-1315 LID - 10.15537/1658-3175.8822 [doi] AB - OBJECTIVE: Fat-rich nutrition may influence the neurochemical consequences of hepatic lipid accumulation. This study examined whether percent energy from fat modifies the association between liver fat and the brain (Cho/Cr) ratio in healthy young women. METHODS: A total of 109 healthy Saudi women aged 18-25 years underwent brain magnetic resonance spectroscopy ((1)H-MRS) to quantify Cho/Cr ratios. Liver fat was estimated using MRI-based proton density fat fraction (PDFF), and lipid intake was assessed using a validated food frequency questionnaire. Multivariable regression models tested the interaction between liver fat and fat-derived energy intake, followed by simple slopes analysis, regression diagnostics, and false discovery rate (FDR) correction. RESULTS: A modest but statistically significant interaction was observed between liver fat and reported fat intake in relation to the brain Cho/Cr ratio (p = 0.037). The association between liver fat and Cho/Cr appeared stronger at higher levels of fat consumption (+1 SD) and weaker at lower intake (-1 SD). Regression diagnostics indicated no multicollinearity or heteroscedasticity, and FDR correction supported the stability of the interaction. CONCLUSION: Fat intake may modify the relationship between liver fat and brain choline metabolism in young women. These findings suggest that nutritional context could play a role in liver-brain metabolic coupling, although the effect size is modest and should be interpreted with caution. CI - Copyright: (c) Saudi Medical Journal. FAU - Hawesa, Halima S AU - Hawesa HS AUID- ORCID: 0000-0002-8478-971X AD - Department of Radiological Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Box 84428, Riyadh 11671, Saudi Arabia. FAU - Shanawani, Mansour E AU - Shanawani ME AD - Department of Radiology, King Abdullah bin Abdulaziz University Hospital, Riyadh, Kingdom of Saudi Arabia. FAU - Alshegri, Haya A AU - Alshegri HA AD - Department of Radiology, King Abdullah bin Abdulaziz University Hospital, Riyadh, Kingdom of Saudi Arabia. FAU - Hassan, Mahasin G AU - Hassan MG AD - College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia. FAU - Alorainy, Amal I AU - Alorainy AI AD - College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia. FAU - Alroqaiba, Nouf A AU - Alroqaiba NA AD - College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia. FAU - Sheikh, Shanoo G A AU - Sheikh SGA AD - College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia. LA - eng PT - Journal Article DEP - 20260707 PL - Saudi Arabia TA - Saudi Med J JT - Saudi medical journal JID - 7909441 RN - N91BDP6H0X (Choline) RN - 0 (Dietary Fats) SB - IM MH - Humans MH - Female MH - *Choline/metabolism MH - *Brain/metabolism MH - *Liver/metabolism MH - Young Adult MH - Adult MH - Saudi Arabia MH - Adolescent MH - *Dietary Fats/administration & dosage MH - Magnetic Resonance Spectroscopy PMC - PMC13360573 OTO - NOTNLM OT - Brain/metabolism OT - Choline/metabolism OT - Dietary fats OT - Fatty liver OT - Female OT - Magnetic resonance spectroscopy OT - Saudi Arabia OT - Young adult EDAT- 2026/07/14 18:26 MHDA- 2026/07/14 18:27 PMCR- 2026/08/01 CRDT- 2026/07/14 06:54 PHST- 2025/11/24 00:00 [received] PHST- 2026/03/27 00:00 [accepted] PHST- 2026/07/14 18:27 [medline] PHST- 2026/07/14 18:26 [pubmed] PHST- 2026/07/14 06:54 [entrez] PHST- 2026/08/01 00:00 [pmc-release] AID - saudimedj-47-8-1309 [pii] AID - 10.15537/1658-3175.8822 [doi] PST - ppublish SO - Saudi Med J. 2026 Aug;47(8):1309-1315. doi: 10.15537/1658-3175.8822. Epub 2026 Jul 7. PMID- 42443053 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 2047-6310 (Electronic) IS - 2047-6302 (Print) IS - 2047-6302 (Linking) VI - 21 IP - 7 DP - 2026 Jul TI - Differences in Fat Depots, Cardiometabolic Risk Factors, and Insulin Resistance Between Active and Passive School Commuters. PG - e70134 LID - 10.1111/ijpo.70134 [doi] LID - e70134 AB - BACKGROUND: Active commuting to and from school (ACS) is a feasible strategy to increase daily physical activity in children. Although ACS has been associated with favourable body composition and selected cardiometabolic markers, its association with specific ectopic fat depots remains unclear in paediatric populations. OBJECTIVE: To examine differences in specific fat depots and cardiometabolic risk factors between children who actively and passively commute to school. METHODS: Cross-sectional baseline data from 174 children (48.9% girls; mean age 10.8 +/- 1.4 years) participating in the EFIGRO and MICROKID projects were analysed. ACS mode was self-reported using a validated questionnaire and classified as active or passive. Visceral adipose tissue, abdominal subcutaneous adipose tissue, intermuscular abdominal adipose tissue, hepatic fat, intrapancreatic fat, and lumbar spine marrow fat were assessed using magnetic resonance imaging. Cardiometabolic risk factors included blood pressure, triglycerides, high-density lipoprotein cholesterol, glucose, insulin, and insulin resistance estimated by the homeostasis model assessment. RESULTS: No significant differences were observed between active and passive commuters for any fat depot (all p >/= 0.150) or cardiometabolic risk factors, including insulin resistance and the overall cardiometabolic risk score (all p >/= 0.220). CONCLUSIONS: Active commuting to/from school was not associated with differences in ectopic fat depots, cardiometabolic risk factors, or insulin resistance in children. CI - (c) 2026 The Author(s). Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation. FAU - Rodriguez-Sanchez, David AU - Rodriguez-Sanchez D AUID- ORCID: 0009-0006-5498-2240 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. FAU - Huertas-Delgado, Francisco Javier AU - Huertas-Delgado FJ AD - "La Inmaculada" Teacher Training Centre, University of Granada, Granada, Spain. FAU - Medrano, Maria AU - Medrano M AD - Department of Health Sciences, Institute for Sustainability & Food Chain Innovation (IS-FOOD), Public University of Navarra, Pamplona, Spain. AD - IdiSNA, Navarra Institute for Health Research, Pamplona, Spain. AD - CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain. FAU - Idoate, Fernando AU - Idoate F AD - Radiology Department, Mutua Navarra, Department of Health Sciences, Public University of Navarra, Pamplona, Spain. FAU - Cabeza, Rafael AU - Cabeza R AD - Department of Electrical, Electronic and Communications Engineering, Public University of Navarra, Pamplona, Spain. FAU - Cadenas-Sanchez, Cristina AU - Cadenas-Sanchez C AUID- ORCID: 0000-0002-4513-9108 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. AD - CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain. FAU - Labayen, Idoia AU - Labayen I AD - Department of Health Sciences, Institute for Sustainability & Food Chain Innovation (IS-FOOD), Public University of Navarra, Pamplona, Spain. AD - IdiSNA, Navarra Institute for Health Research, Pamplona, Spain. AD - CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain. LA - eng GR - DEP2016-78377-R/Spanish Ministry of Industry and Competitiveness/ GR - PI13/01335/Spanish Ministry of Health "Fondos de Investigacion Sanitaria del Instituto de Salud Carlos III"/ GR - 0011-1365-2019-000085/Department of Economic Development of the Government of Navarra/ GR - European Union Structural Funds (European Regional Development Fund, FEDER, "Una manera de hacer Europa")/ GR - FPU23/02198/Spanish Ministry of Universities/ GR - European Union's Horizon 2020/ GR - 101028929/Marie Sklodowska-Curie/ GR - NNF23SA0083955/European Association for the Study of Obesity-Novo Nordisk Foundation/ GR - CB22/03/00058/CIBEROBN/ GR - Instituto de Salud Carlos III, Ministerio de Ciencia e Innovacion, and the European Union/ GR - Universidad de Granada/CBUA/ PT - Journal Article PL - England TA - Pediatr Obes JT - Pediatric obesity JID - 101572033 SB - IM MH - Humans MH - Female MH - *Insulin Resistance MH - Child MH - Cross-Sectional Studies MH - Cardiometabolic Risk Factors MH - Male MH - *Transportation MH - Schools MH - Magnetic Resonance Imaging MH - *Exercise MH - Risk Factors MH - *Cardiovascular Diseases/prevention & control MH - Body Composition MH - Adiposity MH - *Adipose Tissue PMC - PMC13364722 OTO - NOTNLM OT - active transport OT - cardiometabolic health OT - ectopic adiposity OT - metabolic syndrome COIS- The authors declare no conflicts of interest. EDAT- 2026/07/14 00:35 MHDA- 2026/07/14 12:35 PMCR- 2026/07/14 CRDT- 2026/07/13 22:02 PHST- 2026/06/19 00:00 [revised] PHST- 2026/01/22 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/07/14 12:35 [medline] PHST- 2026/07/14 00:35 [pubmed] PHST- 2026/07/13 22:02 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - IJPO70134 [pii] AID - 10.1111/ijpo.70134 [doi] PST - ppublish SO - Pediatr Obes. 2026 Jul;21(7):e70134. doi: 10.1111/ijpo.70134. PMID- 42442333 OWN - NLM STAT- MEDLINE DCOM- 20260824 LR - 20260824 IS - 1873-5150 (Electronic) IS - 0887-8994 (Linking) VI - 182 DP - 2026 Sep TI - The Association Between Polyphenols Intake of Pregnant Mothers and Neurodevelopment Indices in Their Children: The Prospective Epidemiological Research Studies in Iran Birth Cohort-Isfahan. PG - 73-80 LID - S0887-8994(26)00188-8 [pii] LID - 10.1016/j.pediatrneurol.2026.06.015 [doi] AB - BACKGROUND: Polyphenol intake is important for neurological health; however, limited evidence has examined the association between maternal dietary polyphenol intake during pregnancy and children's neurodevelopment. This study aimed to investigate the relationship between maternal polyphenol consumption across pregnancy trimesters and neurodevelopmental outcomes in children. METHODS: This prospective cohort study included 945 mother-child pairs from the Isfahan Birth Cohort. Maternal dietary intake was assessed using a validated 90-item food frequency questionnaire. Polyphenol intake was estimated using the Phenol-Explorer database. Children's neurodevelopment and behavioral outcomes were evaluated using the Ages and Stages Questionnaire and the Child Behavior Checklist. RESULTS: Higher maternal polyphenol intake during the first trimester was associated with lower odds of adverse behavioral outcomes at 2 years of age. In adjusted models, the second (odds ratio [OR]: 0.370, 95% confidence interval [CI]: 0.197-0.693) and third tertiles (OR: 0.523, 95% CI: 0.297-0.920) of polyphenol intake were associated with reduced odds compared to the lowest tertile. Similar associations were observed for the second tertile of polyphenol intake during the first trimester (OR: 0.317, 95% CI: 0.123-0.816) and third trimester (OR: 0.380, 95% CI: 0.152-0.954). No consistent associations were observed at later follow-up ages. CONCLUSIONS: Higher maternal polyphenol intake during pregnancy, particularly in early gestation, may be associated with more favorable early neurodevelopmental and behavioral outcomes. However, these associations were not consistent across all ages, and causality cannot be inferred. Further studies using objective measures of polyphenol exposure and long-term follow-up are warranted. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Amini-Kahrizsangi, Masoud AU - Amini-Kahrizsangi M AD - Nutrition and Food Security Research Center, Department of Community Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Nouri, Fatemeh AU - Nouri F AD - Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Heidari-Beni, Motahar AU - Heidari-Beni M AD - Child Growth and Development Research Center, Department of Nutrition, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: heidari.motahar@gmail.com. FAU - Rouhani, Mohammad Hossein AU - Rouhani MH AD - Nutrition and Food Security Research Center, Department of Community Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Kelishadi, Roya AU - Kelishadi R AD - Child Growth and Development Research Center, Department of Nutrition, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran. LA - eng PT - Journal Article DEP - 20260625 PL - United States TA - Pediatr Neurol JT - Pediatric neurology JID - 8508183 RN - 0 (Polyphenols) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Polyphenols/administration & dosage MH - Iran/epidemiology MH - *Prenatal Exposure Delayed Effects/epidemiology MH - Neurodevelopment MH - Prospective Studies MH - Child, Preschool MH - *Child Development/physiology MH - Adult MH - Birth Cohort MH - Developmental Origins of Health and Disease OTO - NOTNLM OT - Children OT - Neurodevelopment OT - Polyphenols OT - Pregnancy COIS- Fundings This study was conducted as the project number 3403325 supported by Isfahan University of Medical Sciences. EDAT- 2026/07/14 04:10 MHDA- 2026/08/24 23:34 CRDT- 2026/07/13 18:10 PHST- 2025/08/31 00:00 [received] PHST- 2026/05/18 00:00 [revised] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/08/24 23:34 [medline] PHST- 2026/07/14 04:10 [pubmed] PHST- 2026/07/13 18:10 [entrez] AID - S0887-8994(26)00188-8 [pii] AID - 10.1016/j.pediatrneurol.2026.06.015 [doi] PST - ppublish SO - Pediatr Neurol. 2026 Sep;182:73-80. doi: 10.1016/j.pediatrneurol.2026.06.015. Epub 2026 Jun 25. PMID- 42440919 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260713 LR - 20260813 IS - 2673-4915 (Electronic) IS - 2673-4915 (Linking) VI - 7 DP - 2026 TI - Caries risk in toddlers: assessing oral health, microbial factors, and maternal transmission. PG - 1847228 LID - 10.3389/fdmed.2026.1847228 [doi] LID - 1847228 AB - OBJECTIVES: Caries risk begins early in life, yet few studies use intraoral cameras to assess risk in toddlers or examine multiple contributing factors. This study aimed to address this gap and conduct intraoral camera-based assessment of caries and evaluate multiple toddler risk factors, including microbial profiles, oral hygiene practices, and potential maternal transmission. METHODS: Cross-sectional data from 21 maternal-child dyads included intraoral camera assessments coded with an adapted International Caries Detection and Assessment System, saliva-based microbial tests for Streptococcus mutans (SM) and Lactobacillus (LB), and validated surveys of hygiene practices. RESULTS: Among toddlers (N = 21; mean age 3.9 years), intraoral camera use was well tolerated and produced images adequate for assessment. Reliability was good for sound teeth [Intraclass correlation coefficient (ICC) = 0.80], moderate for initial caries (ICC = 0.72), and poor for moderate-to-severe caries (ICC = 0.13). Most teeth were sound (89.0%), with 9.8% mild and 1.1% moderate decay. SM was detected in 9/20 (45.0%) and LB in 4/21 (19.0%) of toddlers. While 81% brushed twice daily, few flossed (14.3%) or used mouthwash (19%); 42.1% consumed soda at least weekly and 19% ate fast food weekly. More frequent brushing was associated with lower SM (Cramer's V = 0.54; p = .02) and LB (V = 0.48; p = .043). Mothers (N = 21; mean age 32.1) had 38.0% of teeth coded as sound, 45.0% with initial caries, and 14.0% with moderate-to-severe decay; 9/21 (42.9%) tested positive for LB and the same proportion tested positive for SM. Most brushed twice daily (81%), with 47.6% flossing and 38.1% using mouthwash. Maternal and toddler brushing frequency (V = 0.68; p = .02), fast-food intake (V = 0.56; p = .01), and microbial positivity (SM: V = 0.93; p = .001; LB: V = 0.54; p = .02) were strongly related. CONCLUSIONS: Intraoral cameras with adapted ICDAS scoring were feasible for assessing caries risk in toddlers. Significant concordance between maternal and child microbial profiles suggests a potential maternal influence on early caries risk. Larger longitudinal studies are needed to clarify transmission pathways and inform prevention strategies. CI - (c) 2026 Scudero, Manning, Mariscal, McNulty, Fidopiastis, Fardanesh, Heaney and Phelan. FAU - Scudero, Emma AU - Scudero E AD - Center for Health Research, California Polytechnic State University, San Luis Obispo, CA, United States. FAU - Manning, Nolan AU - Manning N AD - Center for Health Research, California Polytechnic State University, San Luis Obispo, CA, United States. FAU - Mariscal, Vanessa T AU - Mariscal VT AD - Center for Health Research, California Polytechnic State University, San Luis Obispo, CA, United States. FAU - McNulty, Molly AU - McNulty M AD - Center for Health Research, California Polytechnic State University, San Luis Obispo, CA, United States. FAU - Fidopiastis, Pat AU - Fidopiastis P AD - Center for Health Research, California Polytechnic State University, San Luis Obispo, CA, United States. FAU - Fardanesh, Navid AU - Fardanesh N AD - Community Health Centers of the Central Coast, San Luis Obispo, CA, United States. FAU - Heaney, Casey AU - Heaney C AD - Center for Health Research, California Polytechnic State University, San Luis Obispo, CA, United States. FAU - Phelan, Suzanne AU - Phelan S AD - Center for Health Research, California Polytechnic State University, San Luis Obispo, CA, United States. LA - eng PT - Journal Article DEP - 20260622 PL - Switzerland TA - Front Dent Med JT - Frontiers in dental medicine JID - 101777956 PMC - PMC13333731 OTO - NOTNLM OT - ICDAS OT - intraoral camera OT - maternal transmission OT - oral health OT - toddler COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/13 23:35 MHDA- 2026/07/13 23:36 PMCR- 2026/06/22 CRDT- 2026/07/13 12:32 PHST- 2026/04/06 00:00 [received] PHST- 2026/06/01 00:00 [revised] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/07/13 23:36 [medline] PHST- 2026/07/13 23:35 [pubmed] PHST- 2026/07/13 12:32 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.3389/fdmed.2026.1847228 [doi] PST - epublish SO - Front Dent Med. 2026 Jun 22;7:1847228. doi: 10.3389/fdmed.2026.1847228. eCollection 2026. PMID- 42440723 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260713 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Morphofunctional markers to assess disease-related pediatric malnutrition at admission and their association with length of hospital stay. PG - 1741856 LID - 10.3389/fnut.2026.1741856 [doi] LID - 1741856 AB - BACKGROUND: Disease-related malnutrition (DRM) occurs due to energy imbalance caused by increased catabolism, decreased appetite, or increased energy losses. In hospitalized patients, the presence of DRM can increase morbidity, disability, and mortality, as well as delay recovery from the disease. Therefore, identifying accurate nutritional markers associated with length of stay (LOS) in pediatric patients is important. OBJECTIVE: The objective of this study was to explore the association between morphofunctional markers used to evaluate DRM upon hospital admission and LOS in pediatric patients. METHODS: Exploratory, single-center prospective cohort study was performed in a single center study with patients evaluated within 24-48 h of a third level pediatric hospital. Upon hospital admission, nutritional risk was determinate risk nutritional status screening, anthropometric measurements were made such as weight, height, mid-upper arm circumference (MUAC), calf circumference (CC); body composition with bioelectrical impedance analysis (BIA) and handgrip strength (HGS) was carried out. DRM was diagnosed based on body mass index-for-age z-score (BMIz) < -2 standard deviations (SD). RESULTS: A total of 139 pediatric patients (mean age 12.1 +/- 3.3 years) were included; DRM was present in 15.8%. Among patients with DRM, those who concomitantly presented low phase angle (PhA), low CC, and low HGS had a significantly longer median LOS [15 (5-27) days] than those with values above the established cutoff points [(8 (5-13) days], (p = 0.029). CONCLUSION: In pediatric patients with DRM, lower levels of morphofunctional markers (PhA, HGS, and CC) at hospital admission were associated with prolonged hospital stay. These findings, derived from a Mexican pediatric population, warrant external validation in larger and more diverse cohorts. CI - Copyright (c) 2026 Garcia-Guzman, Pinzon-Navarro, Baldwin-Monroy, Ortiz-Gutierrez, Guevara-Cruz, Avila-Nava and Medina-Vera. FAU - Garcia-Guzman, Alda Daniela AU - Garcia-Guzman AD AD - Servicio de Oncologia Medica, Instituto Nacional de Pediatria, Ciudad de Mexico, Mexico. AD - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ciudad de Mexico, Mexico. FAU - Pinzon-Navarro, Beatriz Adriana AU - Pinzon-Navarro BA AD - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ciudad de Mexico, Mexico. AD - Servicio de Gastroenterologia y Nutricion Pediatrica, Instituto Nacional de Pediatria, Ciudad de Mexico, Mexico. FAU - Baldwin-Monroy, Daffne Danae AU - Baldwin-Monroy DD AD - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ciudad de Mexico, Mexico. AD - Unidad de Terapia Intensiva, Instituto Nacional de Pediatria, Ciudad de Mexico, Mexico. FAU - Ortiz-Gutierrez, Salvador AU - Ortiz-Gutierrez S AD - Departamento de Fisiologia de la Nutricion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Mexico. AD - Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina, Instituto Politecnico Nacional (IPN), Ciudad de Mexico, Mexico. FAU - Guevara-Cruz, Martha AU - Guevara-Cruz M AD - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ciudad de Mexico, Mexico. AD - Departamento de Fisiologia de la Nutricion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Mexico. FAU - Avila-Nava, Azalia AU - Avila-Nava A AD - Hospital Regional de Alta Especialidad Peninsula de Yucatan, Servicios de Salud del Instituto Mexicano del Seguro Social para el Bienestar (IMSS-Bienestar), Merida, Yucatan, Mexico. FAU - Medina-Vera, Isabel AU - Medina-Vera I AD - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ciudad de Mexico, Mexico. AD - Departamento de Metodologia de la Investigacion, Instituto Nacional de Pediatria, Ciudad de Mexico, Mexico. LA - eng PT - Journal Article DEP - 20260622 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13333472 OTO - NOTNLM OT - body composition OT - disease-related malnutrition OT - hospital admission OT - pediatric OT - phase angle COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author MG-C declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/07/13 22:43 MHDA- 2026/07/13 22:44 PMCR- 2026/06/22 CRDT- 2026/07/13 12:24 PHST- 2025/11/07 00:00 [received] PHST- 2026/05/12 00:00 [revised] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/07/13 22:44 [medline] PHST- 2026/07/13 22:43 [pubmed] PHST- 2026/07/13 12:24 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.3389/fnut.2026.1741856 [doi] PST - epublish SO - Front Nutr. 2026 Jun 22;13:1741856. doi: 10.3389/fnut.2026.1741856. eCollection 2026. PMID- 42440670 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Associations of smartphone addiction and physical activity with sleep quality and neck/shoulder symptoms in university students: a cross-sectional study. PG - 1848640 LID - 10.3389/fpubh.2026.1848640 [doi] LID - 1848640 AB - OBJECTIVE: To examine the associations of smartphone addiction, physical activity, and sedentary time with sleep quality and neck/shoulder symptoms during the previous 7 days in university students, and to assess the potential modifying role of physical activity in outcomes associated with smartphone addiction. METHODS: A cross-sectional survey was conducted among 585 students from a single university in Jilin Province, China. Smartphone addiction, physical activity, sedentary time, sleep quality, and neck/shoulder symptoms were assessed using validated questionnaires. Multivariable linear regression and Poisson regression with robust variance were used to examine adjusted associations and interaction terms. RESULTS: Of the participants, 43.8% were classified as having poor sleep, and 46.2% reported at least one neck/shoulder symptoms during the previous 7 days. After adjustment for covariates, higher smartphone addiction and longer sedentary time were both associated with higher PSQI scores, a higher prevalence of poor sleep, and a higher prevalence of neck/shoulder symptoms during the previous 7 days. Meeting physical activity recommendations was associated with lower PSQI scores and a lower prevalence of poor sleep, but showed no independent association with neck/shoulder symptoms. After further adjustment for PSQI, smartphone addiction, sedentary time, and PSQI score were still significantly associated with a higher prevalence of neck/shoulder symptoms. Interaction plots showed descriptively lower predicted PSQI scores and lower predicted probabilities of neck/shoulder symptoms among students who met physical activity recommendations at comparable levels of smartphone addiction; however, the formal interaction terms were not statistically significant. CONCLUSION: Smartphone addiction and sedentary time were consistently associated with poorer sleep quality and more frequent neck/shoulder symptoms. Physical activity was more consistently associated with sleep outcomes than with neck/shoulder symptoms. These findings support considering smartphone use, sedentary behaviour, physical activity, and sleep management together in campus health promotion research. CI - Copyright (c) 2026 Yue, Cao, Zhao, Wang, Lai, Zhang and Cui. FAU - Yue, Wei AU - Yue W AD - College of Physical Education, Jilin Normal University, Siping, Jilin, China. FAU - Cao, Shen AU - Cao S AD - Football School, Hebei Institute of Communications, Shijiazhuang, Hebei, China. FAU - Zhao, Jinglei AU - Zhao J AD - School of Culture, Tourism, Health and Wellness Education, Dongying Vocational College, Dongying, Shandong, China. FAU - Wang, Qin AU - Wang Q AD - School of Culture, Tourism, Health and Wellness Education, Dongying Vocational College, Dongying, Shandong, China. FAU - Lai, Weigang AU - Lai W AD - Sports Committee, Dongying Vocational College, Dongying, China. FAU - Zhang, Jinhui AU - Zhang J AD - Faculty of Education and Liberal Studies, City University Malaysia, Kuala Lumpur, Malaysia. FAU - Cui, Yuexin AU - Cui Y AD - Office of Academic Affairs, Dongying Vocational College, Dongying, China. LA - eng PT - Journal Article DEP - 20260622 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - *Students/statistics & numerical data/psychology MH - *Exercise MH - Male MH - Universities MH - *Shoulder Pain/epidemiology MH - *Sleep Quality MH - China/epidemiology MH - *Smartphone/statistics & numerical data MH - Young Adult MH - *Neck Pain/epidemiology MH - Surveys and Questionnaires MH - Sedentary Behavior MH - Adult MH - Adolescent MH - *Internet Addiction Disorder/epidemiology PMC - PMC13333704 OTO - NOTNLM OT - neck/shoulder symptoms OT - physical activity OT - sedentary behaviour OT - sleep quality OT - smartphone addiction COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/13 23:35 MHDA- 2026/07/13 23:36 PMCR- 2026/06/22 CRDT- 2026/07/13 12:22 PHST- 2026/04/06 00:00 [received] PHST- 2026/05/19 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/07/13 23:36 [medline] PHST- 2026/07/13 23:35 [pubmed] PHST- 2026/07/13 12:22 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1848640 [doi] PST - epublish SO - Front Public Health. 2026 Jun 22;14:1848640. doi: 10.3389/fpubh.2026.1848640. eCollection 2026. PMID- 42437943 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261008 IS - 2072-1315 (Electronic) IS - 1606-0997 (Print) IS - 1606-0997 (Linking) VI - 45 IP - 1 DP - 2026 Jul 12 TI - Associations of starchy and non-starchy vegetable intake with depression, anxiety, stress, chronotype, and sleep quality among iranian women with overweight or obesity: a cross-sectional study. LID - 10.1186/s41043-026-01392-w [doi] LID - 217 AB - BACKGROUND: Starchy vegetables may influence psychological well-being, circadian alignment, and sleep quality through their glycemic characteristics and related metabolic effects. In contrast, non‑starchy vegetables, which differ substantially in nutrient density and bioactive compounds, may affect these outcomes through alternative physiological pathways. Despite these distinct nutritional profiles, evidence comparing their separate associations with mental health and sleep-related patterns is limited. This study explored these relationships among overweight and obese women. METHODS: In this cross-sectional study, 391 overweight and obese women aged 18-48 years were recruited using a cluster sampling strategy from community health centres. Data collection was conducted through structured face‑to‑face interviews performed by trained nutritionists. Mental health indicators (depression, anxiety, and stress) were assessed using the Persian DASS‑21, sleep quality was evaluated using the PSQI, and circadian preference was measured using the MEQ. Dietary intake was obtained through a validated 147‑item food frequency questionnaire (FFQ). Anthropometric measurements, blood samples, biochemical markers, physical activity, and demographic information were collected following standardized procedures. RESULTS: The study included 391 women, with a mean age of 38.08 +/- 8.61 years in the high non-starchy vegetable intake group and 35.31 +/- 9.59 years in the low non-starchy vegetable intake group, all classified as overweight or obese. Participants with higher non‑starchy vegetable intake exhibited significantly lower odds of depression (adjusted OR = 0.40, 95% CI = 0.20-0.79, P < 0.001) and stress (adjusted OR = 0.30, 95% CI = 0.14-0.85, P = 0.02). Higher non‑starchy vegetable consumption was also associated with improved sleep quality (adjusted OR = 0.38, 95% CI = 0.19-0.77, P = 0.007). Furthermore, increased starchy vegetable intake was inversely associated with the morning-type chronotype (adjusted OR = 0.27, 95% CI = 0.09-0.83, P = 0.02) after full adjustment. CONCLUSIONS: Higher non-starchy vegetable intake was associated with lower odds of depression, stress, and poor sleep quality, while greater starchy vegetable consumption was linked to a lower likelihood of morning-type chronotype. Increasing non-starchy vegetable intake may support psychological well-being and sleep health, though longitudinal studies are needed to confirm causality. CI - (c) 2026. The Author(s). FAU - Roumi, Zahra AU - Roumi Z AD - Department of Clinical Nutrition and Dietetics , Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Mirzababaei, Atieh AU - Mirzababaei A AD - Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. ati_babaee@yahoo.com. AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. ati_babaee@yahoo.com. FAU - Abaj, Faezeh AU - Abaj F AD - Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, VIC, Australia. FAU - Clark, Cain C T AU - Clark CCT AD - Centre for Intelligent Healthcare, CV1 5FB, Coventry, U.K. FAU - Jadidi, Paria AU - Jadidi P AD - Department of Nutrition, SR.C, Islamic Azad University, Tehran, Iran. FAU - Rasekhmagham, Reyhaneh AU - Rasekhmagham R AD - Department of Nutrition, SR.C, Islamic Azad University, Tehran, Iran. FAU - Mirzaei, Khadijeh AU - Mirzaei K AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. LA - eng GR - 97-03-161-41155/Tehran University of Medical Sciences and Health Services/ PT - Journal Article DEP - 20260712 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Adult MH - Iran/epidemiology MH - Middle Aged MH - *Depression/epidemiology MH - Chronotype MH - *Obesity/psychology MH - *Sleep Quality MH - *Vegetables MH - *Stress, Psychological/epidemiology MH - *Overweight/psychology MH - *Anxiety/epidemiology MH - Adolescent MH - Young Adult MH - *Diet MH - Sleep PMC - PMC13640202 OTO - NOTNLM OT - Circadian rhythm OT - Female population OT - Mental health OT - Obesity OT - Sleep quality OT - Starchy/non-starchy vegetables COIS- Declarations. Ethics approval and consent to participate: The authors and the Ethics Committee of Tehran University of Medical Sciences (IR.TUMS.VCR.REC.1398.692) have received approval for the method and protocol of the current study. Additionally, written informed consent has been obtained from all participants. Consent for publication: All authors collaborated in editing this article, and the final version was approved for submission. Furthermore, they actively participated in writing the manuscript and giving their approval to the final draft. Competing interests: The authors declare no competing interests. EDAT- 2026/07/13 04:09 MHDA- 2026/10/07 06:25 PMCR- 2026/07/12 CRDT- 2026/07/12 23:39 PHST- 2025/12/04 00:00 [received] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/10/07 06:25 [medline] PHST- 2026/07/13 04:09 [pubmed] PHST- 2026/07/12 23:39 [entrez] PHST- 2026/07/12 00:00 [pmc-release] AID - 10.1186/s41043-026-01392-w [pii] AID - 1392 [pii] AID - 10.1186/s41043-026-01392-w [doi] PST - epublish SO - J Health Popul Nutr. 2026 Jul 12;45(1):217. doi: 10.1186/s41043-026-01392-w. PMID- 42436557 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260911 IS - 1757-2215 (Electronic) IS - 1757-2215 (Linking) VI - 19 IP - 1 DP - 2026 Jul 11 TI - Psychological distress and quality of life in women with infertility due to polycystic ovarian syndrome versus unexplained infertility: a cross-sectional study with phenotype-based analysis. LID - 10.1186/s13048-026-02186-8 [doi] LID - 268 AB - BACKGROUND: Infertility is associated with significant psychological distress and impaired quality of life (QoL) in women. Polycystic Ovarian Syndrome (PCOS), a common cause of infertility, is frequently associated with metabolic and psychological symptoms. However, limited evidence directly compares psychological symptom burden and QoL between women with PCOS-related infertility and unexplained infertility, including across PCOS phenotypes. METHODS: This cross-sectional observational study included 240 women aged 18-40 years with infertility due to PCOS or unexplained causes, conducted at a tertiary care center between October 2019 and March 2021. PCOS was diagnosed using revised Rotterdam criteria, and unexplained infertility was defined after exclusion of known causes. Psychological outcomes were assessed using validated screening instruments (PHQ-9, BDI, BAI, and GAD-7), representing symptom severity rather than clinical psychiatric diagnoses. QoL was assessed using WHOQOL-BREF. Statistical analysis included group comparisons using appropriate parametric and non-parametric tests, with p < 0.05 considered statistically significant. RESULTS: Women with PCOS demonstrated significantly higher screening-based depressive symptom burden (60% vs. 14%, p < 0.001) and anxiety symptom burden (63% vs. 21%, p < 0.001) compared to women with unexplained infertility. QoL scores were significantly lower in the PCOS group (66.8% vs. 85.1%, p < 0.001), particularly in psychological and social domains. Among PCOS phenotypes, hyperandrogenic phenotypes (B and C) showed relatively higher psychological symptom burden and lower QoL scores compared to other phenotypes. The PCOS group also demonstrated higher BMI and androgen levels. CONCLUSION: Infertility associated with PCOS is linked to higher screening-based psychological symptom burden and reduced quality of life compared to unexplained infertility. Hyperandrogenic PCOS phenotypes appear to be more affected. These findings support the integration of routine psychological screening and multidisciplinary support into infertility care for women with PCOS. CI - (c) 2026. The Author(s). FAU - Kataria, Kamna AU - Kataria K AD - Department of Obstetrics & Gynecology, VMMC & Safdarjung Hospital, New Delhi, 110029, India. FAU - Kapoor, Garima AU - Kapoor G AD - Department of Obstetrics & Gynecology, VMMC & Safdarjung Hospital, New Delhi, 110029, India. garimak79@yahoo.co.in. FAU - Saha, Rahul AU - Saha R AD - Department of Psychiatry at VMMC & Safdarjung Hospital, New Delhi, 110029, India. FAU - Lachyan, Abhishek AU - Lachyan A AD - Department of Obstetrics & Gynecology, VMMC & Safdarjung Hospital, New Delhi, 110029, India. LA - eng PT - Journal Article PT - Observational Study DEP - 20260711 PL - England TA - J Ovarian Res JT - Journal of ovarian research JID - 101474849 SB - IM MH - Humans MH - Female MH - *Polycystic Ovary Syndrome/complications/psychology MH - *Quality of Life/psychology MH - Cross-Sectional Studies MH - Adult MH - *Infertility, Female/psychology/etiology MH - Phenotype MH - Young Adult MH - Adolescent MH - *Psychological Distress PMC - PMC13508219 OTO - NOTNLM OT - Anxiety OT - Depression OT - Infertility OT - PCOS phenotypes OT - Polycystic ovarian syndrome OT - Quality of life COIS- Declarations. Ethics approval and consent to participate: Ethical approval for this study was obtained from the Institutional Ethics Committee of VMMC & Safdarjung Hospital (IEC approval no. IEC/VMMC/SJH/THESIS/2019-10/89; approved on 30 October 2019). The study was conducted in accordance with the principles of the Declaration of Helsinki (2013 revision). Written informed consent was obtained from all participants prior to their inclusion in the study. Competing interests: The authors declare no competing interests. EDAT- 2026/07/12 00:56 MHDA- 2026/08/27 05:35 PMCR- 2026/07/11 CRDT- 2026/07/11 23:38 PHST- 2026/02/24 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/08/27 05:35 [medline] PHST- 2026/07/12 00:56 [pubmed] PHST- 2026/07/11 23:38 [entrez] PHST- 2026/07/11 00:00 [pmc-release] AID - 10.1186/s13048-026-02186-8 [pii] AID - 2186 [pii] AID - 10.1186/s13048-026-02186-8 [doi] PST - epublish SO - J Ovarian Res. 2026 Jul 11;19(1):268. doi: 10.1186/s13048-026-02186-8. PMID- 42436527 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261009 IS - 1824-7288 (Electronic) IS - 1720-8424 (Linking) VI - 52 IP - 1 DP - 2026 Jul 11 TI - Occurrence of diarrhea in pediatric bronchopneumonia patients: relevance to nursing management. LID - 10.1186/s13052-026-02301-x [doi] LID - 149 AB - BACKGROUND: Diarrhea represents a frequent complication in pediatric patients with bronchopneumonia. This study was designed to identify independent risk factors for diarrheal complications and to propose evidence-informed nursing interventions. METHODS: A retrospective cohort study was conducted among 280 hospitalized children with bronchopneumonia. Demographic, anthropometric, laboratory, and treatment-related data were extracted from electronic medical records. Multicollinearity was assessed by variance inflation factor (VIF), and independent risk factors were identified through binary logistic regression with model fit evaluated by the Hosmer-Lemeshow test. RESULTS: The incidence of diarrhea was 23.57%. Eight independent risk factors were identified: antibiotic duration >/= 7 days (OR = 3.006), beta-lactamase inhibitor combination use (OR = 2.916), combined antibiotic use (OR = 2.401), mixed pulmonary infection (OR = 2.105), age < 5 years (OR = 2.048), weight-for-height/length z-score < - 2 (OR = 1.982), serum albumin < 35 g/L (OR = 1.896), and C-reactive protein >/= 20 mg/L (OR = 1.845). Probiotic administration was an independent protective factor (OR = 0.849). All VIF values were < 5, and the Hosmer-Lemeshow test indicated adequate model fit (P > 0.05). CONCLUSION: Diarrhea in children with bronchopneumonia is associated with multiple clinical and therapeutic variables, with beta-lactamase inhibitor combinations and prolonged antibiotic therapy conferring the highest risk. These findings provide a hypothesis-generating foundation for risk-stratified nursing strategies to reduce diarrheal complications. However, given the retrospective design and the inability to distinguish antibiotic-associated diarrhea from infectious diarrhea, the identified associations should be interpreted cautiously, and any derived clinical recommendations require prospective validation. CI - (c) 2026. The Author(s). FAU - Tang, Yinyan AU - Tang Y AD - Department of pediatrics, Nanjing Lishui People's Hospital, No. 86 Chongwen Road, Lishui District, Nanjing, Jiangsu Province, China. FAU - Zhang, Qian AU - Zhang Q AD - Department of pediatrics, Nanjing Lishui People's Hospital, No. 86 Chongwen Road, Lishui District, Nanjing, Jiangsu Province, China. FAU - Yu, Tingting AU - Yu T AD - Department of pediatrics, Nanjing Lishui People's Hospital, No. 86 Chongwen Road, Lishui District, Nanjing, Jiangsu Province, China. 564440307@qq.com. LA - eng PT - Journal Article DEP - 20260711 PL - England TA - Ital J Pediatr JT - Italian journal of pediatrics JID - 101510759 RN - 0 (Anti-Bacterial Agents) SB - IM MH - Humans MH - Retrospective Studies MH - *Diarrhea/epidemiology/nursing/etiology MH - *Bronchopneumonia/complications/drug therapy/nursing MH - Female MH - Male MH - Risk Factors MH - Child, Preschool MH - Infant MH - Incidence MH - Anti-Bacterial Agents/adverse effects MH - Child PMC - PMC13644138 OTO - NOTNLM OT - Bronchopneumonia OT - Children OT - Clinical OT - Diarrhea OT - Nursing OT - Treatment COIS- Declarations. Ethics approval and consent to participate: In this study, all methods were performed in accordance with the relevant guidelines and regulations. The study has been reviewed and approved by the ethics committee of Nanjing Lishui People's Hospital (Ethics Approval No.: 2025KY0922-02). Although written informed consent from the children's guardians was not separately obtained due to the retrospective nature of the study, the Ethics Committee has verified that: the research data are non-identifiable information generated during routine clinical diagnosis and treatment; the study results can be used to clarify the influencing factors of bronchopneumonia complicated with diarrhea in children and optimize clinical nursing protocols, ultimately providing evidence-based support for reducing the incidence of pneumonia-related complications in children and improving their prognosis. The public health value and potential benefits of the study are significantly greater than the risks, which is in line with the ethical principle of "reasonable risk-benefit ratio". Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/07/12 04:10 MHDA- 2026/10/07 05:31 PMCR- 2026/07/11 CRDT- 2026/07/11 23:37 PHST- 2026/04/04 00:00 [received] PHST- 2026/06/20 00:00 [accepted] PHST- 2026/10/07 05:31 [medline] PHST- 2026/07/12 04:10 [pubmed] PHST- 2026/07/11 23:37 [entrez] PHST- 2026/07/11 00:00 [pmc-release] AID - 10.1186/s13052-026-02301-x [pii] AID - 2301 [pii] AID - 10.1186/s13052-026-02301-x [doi] PST - epublish SO - Ital J Pediatr. 2026 Jul 11;52(1):149. doi: 10.1186/s13052-026-02301-x. PMID- 42434646 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260711 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 6 DP - 2026 Jun TI - Accuracy Assessment of a Wrist-Worn Oscillometric Blood Pressure Device Applied to the Upper Arm in Children. PG - e110605 LID - 10.7759/cureus.110605 [doi] LID - e110605 AB - Background Accurate blood pressure (BP) measurement in children is essential for detecting pediatric hypertension, yet validation evidence for wrist-worn oscillometric devices in this population is sparse. The nonstandard application of a wrist BP device to the upper arm, a clinically plausible scenario when cuff size is compatible with a child's arm circumference, has not been previously evaluated. This study aimed to evaluate the accuracy and validation of a wrist-worn oscillometric BP device applied to the upper arm in children aged 3-8.5 years using brachial auscultatory mercury sphygmomanometry as the reference standard. Methodology This prospective, cross-sectional validation study enrolled 100 children (58 males; mean age = 4.9 +/- 1.5 years) in a tertiary care hospital. A wrist-worn oscillometric device was applied to the upper arm and compared with brachial auscultatory mercury sphygmomanometry using the International Organization for Standardization (ISO) 81060-2:2018. A same-arm sequential protocol was used, yielding 300 paired comparisons. Accuracy was assessed using ISO Criteria 1 and 2, the British Hypertension Society (BHS) grading, and Bland-Altman analysis. Additionally, proportional bias regression and subgroup analyses were performed. Results The device met both ISO criteria for systolic BP (SBP; mean error = -4.62 +/- 6.02 mmHg) and diastolic BP (DBP; -2.70 +/- 5.19 mmHg). BHS grading was Grade A for DBP and Grade B for SBP. Bland-Altman 95% limits of agreement were -16.41 to +7.17 mmHg (SBP) and -12.88 to +7.48 mmHg (DBP). Significant proportional bias was observed for SBP (r = 0.370, p < 0.001) and DBP (r = 0.153, p = 0.008) with increasing underestimation at higher BP values. No sex differences were identified; a statistically significant but small age group difference was observed for DBP only. Conclusions This wrist-worn device applied to the upper arm met ISO validation requirements in 3-8.5-year-old children, and achieved BHS Grade A for DBP and Grade B for SBP. This device may be used as a screening tool in children of the tested age range, with confirmatory brachial auscultation recommended for elevated readings. The predominantly normotensive BP distribution in this cohort limits generalization of performance to hypertensive pediatric populations. Future studies should confirm our findings, recruit broader BP distributions, assess diverse anthropometrics, evaluate movement sensitivity, and explore pediatric-specific algorithms to reduce SBP proportional bias. CI - Copyright (c) 2026, Mahapatra et al. FAU - Mahapatra, Akankshya AU - Mahapatra A AD - Pediatrics, Mahatma Gandhi Mission Medical College and Hospital, Mahatma Gandhi Mission Institute of Health Sciences, Aurangabad, IND. FAU - Siddiqui, Mohd Saeed AU - Siddiqui MS AD - Pediatrics, Mahatma Gandhi Mission Medical College and Hospital, Mahatma Gandhi Mission Institute of Health Sciences, Aurangabad, IND. FAU - Haseeb, Mohammad AU - Haseeb M AD - Pediatrics, Mahatma Gandhi Mission Medical College and Hospital, Mahatma Gandhi Mission Institute of Health Sciences, Aurangabad, IND. FAU - Sangle, Avinash L AU - Sangle AL AD - Pediatrics, Mahatma Gandhi Mission Medical College and Hospital, Mahatma Gandhi Mission Institute of Health Sciences, Aurangabad, IND. FAU - Ingale, Vinod AU - Ingale V AD - Pediatrics, Mahatma Gandhi Mission Medical College and Hospital, Mahatma Gandhi Mission Institute of Health Sciences, Aurangabad, IND. FAU - Joshi, Pradnya M AU - Joshi PM AD - Pediatrics, Mahatma Gandhi Mission Medical College and Hospital, Mahatma Gandhi Mission Institute of Health Sciences, Aurangabad, IND. FAU - Supe, Prajakta AU - Supe P AD - Pediatrics, Mahatma Gandhi Mission Medical College and Hospital, Mahatma Gandhi Mission Institute of Health Sciences, Aurangabad, IND. FAU - Sachdev, Siddhant AU - Sachdev S AD - Pediatrics, Mahatma Gandhi Mission Medical College and Hospital, Mahatma Gandhi Mission Institute of Health Sciences, Aurangabad, IND. FAU - Shaikh, Rabiah AU - Shaikh R AD - Pediatrics, Mahatma Gandhi Mission Medical College and Hospital, Mahatma Gandhi Mission Institute of Health Sciences, Aurangabad, IND. FAU - Mohapatra, Abinash AU - Mohapatra A AD - Pediatrics, Mahatma Gandhi Mission Medical College and Hospital, Mahatma Gandhi Mission Institute of Health Sciences, Aurangabad, IND. LA - eng PT - Journal Article DEP - 20260610 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13353792 OTO - NOTNLM OT - blood pressure (bp) OT - british hypertension society OT - children OT - iso 81060-2 OT - oscillometric OT - validation OT - wrist device COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Mahatma Gandhi Mission Ethics Committee for Research on Human Subjects issued approval MGM-ECRHS/2024/120. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/07/11 06:36 MHDA- 2026/07/11 06:37 PMCR- 2026/06/10 CRDT- 2026/07/11 05:19 PHST- 2026/06/10 00:00 [accepted] PHST- 2026/07/11 06:37 [medline] PHST- 2026/07/11 06:36 [pubmed] PHST- 2026/07/11 05:19 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.7759/cureus.110605 [doi] PST - epublish SO - Cureus. 2026 Jun 10;18(6):e110605. doi: 10.7759/cureus.110605. eCollection 2026 Jun. PMID- 42433965 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260711 LR - 20260813 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 6 DP - 2026 Jun 30 TI - Development and external validation of machine learning models to predict insulin resistance among iron-deficient children and adolescents. PG - 231 LID - 10.21037/tp-2026-1-0146 [doi] LID - 231 AB - BACKGROUND: Insulin resistance (IR) represents a critical metabolic complication in iron-deficient children, yet existing predictive models target general or overweight pediatric populations and do not account for iron-deficiency as a distinct risk modifier. This study aimed to develop and externally validate machine learning (ML) models using routinely available clinical parameters to address this diagnostic gap. METHODS: We utilized data from 222 iron-deficient children and adolescents aged 6 to 17 years from the China Health and Nutrition Survey (CHNS) for model training, and 125 cases from two hospitals for external validation. Iron-deficiency was defined using age- and sex-specific soluble transferrin receptor (sTfR) thresholds, with exclusion of elevated high-sensitivity C-reactive protein (hs-CRP) (>/=5 mg/L) or missing metabolic variables. IR was defined as Homeostatic Model Assessment for Insulin Resistance (HOMA IR) exceeding 3.0. Least Absolute Shrinkage and Selection Operator (LASSO) regression selected nine predictors from 27 candidate variables (demographics, anthropometrics, blood pressure, hematology, glucose metabolism, lipids, hepatic and renal function). Four ML algorithms [logistic regression (LR), random forest (RF), k-nearest neighbor (KNN), and extreme gradient boosting (XGBoost)] were developed and evaluated by area under the curve, sensitivity, specificity, and calibration, with five-fold repeated cross-validation for internal validation. SHapley Additive exPlanations (SHAP) analysis quantified predictor contributions. RESULTS: XGBoost achieved optimal discriminative performance with an external validation area under the receiver operating characteristic curve (AUC) of 0.940 [95% confidence interval (CI): 0.889-0.991], outperforming other algorithms. RF demonstrated the highest training AUC (0.993, 95% CI: 0.987-1.000) with near-perfect sensitivity (0.985, 95% CI: 0.920-1.000) but showed limited generalization capacity given minimal training-validation divergence. LR and KNN achieved lower validation AUC values of 0.832 (95% CI: 0.743-0.922) and 0.823 (95% CI: 0.740-0.905), respectively. XGBoost was selected as the final model based on superior specificity (0.967, 95% CI: 0.906-0.993) and tighter CIs, indicating more stable performance estimation. Fasting glucose (mean |SHAP| =0.707) and triglycerides (0.383) emerged as dominant predictors, while albumin demonstrated a protective association [odds ratio (OR) 0.86, 95% CI: 0.78-0.95]. CONCLUSIONS: This study establishes an externally validated, interpretable ML framework for predicting IR among iron-deficient youth using routine clinical data. While the XGBoost model demonstrates promising discriminative performance and geographic generalizability, the modest sample size and single-province validation limit immediate deployment readiness. Prospective multi-site validation is required before any consideration of clinical implementation as a developmental screening framework. CI - (c) AME Publishing Company. FAU - Bai, Jing AU - Bai J AD - Pediatric Department, Beijing Anzhen Nanchong Hospital of Capital Medical University & Nanchong Central Hospital, Nanchong, China. FAU - Fang, Xiao AU - Fang X AUID- ORCID: 0009-0005-7358-1349 AD - National Science Library (Chengdu), Chinese Academy of Sciences, Chengdu, China. FAU - Ding, Xiaoyan AU - Ding X AD - Pediatric Department, Beijing Anzhen Nanchong Hospital of Capital Medical University & Nanchong Central Hospital, Nanchong, China. FAU - Huang, Xiu AU - Huang X AD - Pediatric Department, Nanchong City Jialing District People's Hospital (Jialing Branch of Nanchong Central Hospital), Nanchong, China. LA - eng PT - Journal Article DEP - 20260515 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13351654 OTO - NOTNLM OT - Machine learning (ML) OT - children OT - external validation OT - insulin resistance (IR) OT - iron-deficiency COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-1-0146/coif). The authors have no conflicts of interest to declare. EDAT- 2026/07/11 16:11 MHDA- 2026/07/11 16:12 PMCR- 2026/06/30 CRDT- 2026/07/11 05:11 PHST- 2026/02/04 00:00 [received] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/07/11 16:12 [medline] PHST- 2026/07/11 16:11 [pubmed] PHST- 2026/07/11 05:11 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - tp-15-06-231 [pii] AID - 10.21037/tp-2026-1-0146 [doi] PST - ppublish SO - Transl Pediatr. 2026 Jun 30;15(6):231. doi: 10.21037/tp-2026-1-0146. Epub 2026 May 15. PMID- 42433955 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260711 LR - 20260813 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 6 DP - 2026 Jun 30 TI - Associations of picky eating levels with dietary diversity, nutrient intake, and eating behaviors in preschool children with autism spectrum disorder: a cross-sectional study. PG - 214 LID - 10.21037/tp-2026-1-0168 [doi] LID - 214 AB - BACKGROUND: Picky eating is common among children with autism spectrum disorder (ASD). However, the specific effects of different levels of picky eating on nutritional status, dietary diversity, and eating behaviors in preschool-aged children with ASD remain unclear. This study aimed to compare these aspects between children with low versus high levels of picky eating. METHODS: A cross-sectional study design was employed, enrolling 130 children with ASD aged 3 to 6 years who met the DSM-5 diagnostic criteria [Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-V)]. Trained personnel measured each child's height and weight using standardized instruments. Validated dietary diversity scores and preschool eating behavior scales were used to assess dietary diversity and nutrient intake and eating behaviors. energy and macronutrient intake were quantified through three non-consecutive 24-hour dietary recalls. Children were divided into a low picky eating group and a high picky eating group based on the degree of picky eating for comparative analysis. RESULTS: There were no statistically significant differences in height and weight indicators between the two groups, with most children falling within the normal range of growth and development. However, distinct differences were observed in nutrient intake and eating behaviors: children in the low picky eating group showed significantly higher total dietary diversity scores (P<0.05). Regarding nutrient intake, children in the low picky eating group exhibited higher intake levels of total energy, polyunsaturated fatty acids, and dietary fiber compared to those in the high picky eating group; in specific food categories, intake of starchy tubers, fruits, nuts, and legumes was also significantly higher. Regarding eating behaviors, children in the low picky eating group showed lower scores for picky eating and problematic eating behaviors, whereas exhibited heightened satiety responsiveness, with all differences reaching statistical significance (P<0.05). CONCLUSIONS: The degree of picky eating is a key factor influencing dietary quality and eating behaviors in preschool-age children with ASD. Low levels of picky eating are associated with more comprehensive nutrient intake, richer dietary diversity, and more favorable eating behavior patterns. Early identification and intervention targeting picky eating behavior are of significant importance for improving the nutritional status of children with ASD. CI - (c) AME Publishing Company. FAU - Wang, Shasha AU - Wang S AD - Department of Pediatric Health Care, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Qi, Ye AU - Qi Y AD - Department of Pediatric Health Care, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Yao, Dan AU - Yao D AD - Department of Pediatric Health Care, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. LA - eng PT - Journal Article DEP - 20260626 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13351710 OTO - NOTNLM OT - Autism spectrum disorder (ASD) OT - nutritional status OT - picky eating COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-1-0168/coif). The authors have no conflicts of interest to declare. EDAT- 2026/07/11 16:11 MHDA- 2026/07/11 16:12 PMCR- 2026/06/30 CRDT- 2026/07/11 05:11 PHST- 2026/02/14 00:00 [received] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/07/11 16:12 [medline] PHST- 2026/07/11 16:11 [pubmed] PHST- 2026/07/11 05:11 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - tp-15-06-214 [pii] AID - 10.21037/tp-2026-1-0168 [doi] PST - ppublish SO - Transl Pediatr. 2026 Jun 30;15(6):214. doi: 10.21037/tp-2026-1-0168. Epub 2026 Jun 26. PMID- 42433404 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Development and validation of a scale of healthy psychological effects of physical exercise among Chinese college students from a multidimensional mental health perspective. PG - 1866486 LID - 10.3389/fpubh.2026.1866486 [doi] LID - 1866486 AB - BACKGROUND: Physical exercise promotes mental health among college students, but existing studies often assess general mental health or limited psychological indicators, making it difficult to capture comprehensive healthy psychological effects after exercise. This study aimed to develop and validate the Healthy Psychological Effects of Physical Exercise Scale for College Students. METHODS: An initial scale was developed through theoretical analysis, literature review, semi-structured interviews, and open-ended questionnaires. In an initial sample of 612 college students, item analysis and exploratory factor analysis with varimax rotation were conducted to screen items and identify factor structures. A formal sample of 945 participants was used to examine reliability and validity through Cronbach's alpha, composite reliability (CR), average variance extracted (AVE), confirmatory factor analysis (CFA), and criterion-related validity testing. Test-retest reliability was assessed in 597 participants after 1 month. RESULTS: The final scale contained 55 items across five subscales: emotional feelings, self-cognition, frustration coping, self-control and social adaptation efficacy, and interpersonal interaction, comprising 15 subdimensions. Exploratory factor analyses supported clear three-factor structures for each subscale, with cumulative variance explained ranging from 62.546 to 73.711%. CFA indicated good fit for the five subscales (chi(2) /df = 2.978-4.391; RMSEA = 0.046-0.060; SRMR = 0.016-0.021; CFI = 0.978-0.988; TLI = 0.971-0.984), and acceptable fit for the overall model (chi(2) /df = 3.037; RMSEA = 0.046; SRMR = 0.041; CFI = 0.925; TLI = 0.921). Cronbach's alpha and CR for the 15 subdimensions ranged from 0.873 to 0.931, and AVE ranged from 0.680 to 0.736. Cronbach's alpha for the five subscale total scores ranged from 0.861 to 0.894. Test-retest reliability ranged from 0.706 to 0.781 for subdimensions and from 0.686 to 0.771 for subscale total scores. Criterion-related validity was supported by significant positive correlations with positive psychological indicators (r = 0.229-0.383) and negative correlations with negative psychological indicators (r = -0.398 to -0.224; all p < 0.001). CONCLUSION: The scale demonstrates sound reliability and validity and can be used to assess exercise-related healthy psychological effects among college students. CI - Copyright (c) 2026 Liu, Zhu, He, Zhu and Guo. FAU - Liu, Feiyang AU - Liu F AD - School of Physical Education, Southwest University, Chongqing, China. FAU - Zhu, Zhengguang AU - Zhu Z AD - Research Center of Mental Health Education, Southwest University, Chongqing, China. FAU - He, Rongqiao AU - He R AD - School of Physical Education, Southwest University, Chongqing, China. FAU - Zhu, Yu AU - Zhu Y AD - School of Physical Education, Southwest University, Chongqing, China. FAU - Guo, Liya AU - Guo L AD - School of Physical Education, Southwest University, Chongqing, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260626 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Students/psychology/statistics & numerical data MH - Female MH - Universities MH - Reproducibility of Results MH - *Exercise/psychology MH - Young Adult MH - Male MH - Surveys and Questionnaires/standards MH - *Mental Health MH - China MH - Psychometrics MH - Adolescent MH - Factor Analysis, Statistical MH - Adult MH - Adaptation, Psychological PMC - PMC13352479 OTO - NOTNLM OT - college students OT - healthy psychological effects OT - mental health OT - physical exercise OT - scale development COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/11 06:35 MHDA- 2026/07/12 00:55 PMCR- 2026/06/26 CRDT- 2026/07/11 05:06 PHST- 2026/04/27 00:00 [received] PHST- 2026/06/06 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/07/12 00:55 [medline] PHST- 2026/07/11 06:35 [pubmed] PHST- 2026/07/11 05:06 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1866486 [doi] PST - epublish SO - Front Public Health. 2026 Jun 26;14:1866486. doi: 10.3389/fpubh.2026.1866486. eCollection 2026. PMID- 42433322 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260711 LR - 20260813 IS - 2950-5410 (Electronic) IS - 2950-5410 (Linking) VI - 21 DP - 2026 Oct TI - Evaluating Empowerment in Adolescents with a Disability and/or Chronic Condition from Neurology and Orthopedic Clinics: A Mixed-Methods Study. PG - 200220 LID - 10.1016/j.jpedcp.2026.200220 [doi] LID - 200220 AB - OBJECTIVE: To evaluate empowerment and quality of life in adolescents (10-19 years of age) with chronic conditions and/or disabilities from neurology and orthopedic clinics and identify areas to improve their care and empowerment. STUDY DESIGN: We utilized a mixed-methods design with an explanatory sequential approach. Participants were recruited from neurology and orthopedic clinics at BC Children's Hospital and completed a demographic survey and two validated online tools: The Gothenburg Young Person's Empowerment Scale (GYPES) and Pediatric Quality of Life (PedsQL) 4.0 self-report. Semi-structured interviews were conducted to gain a deeper understanding of adolescents' feelings of empowerment. Linear regression analysis was performed to identify demographic variables associated with decreased empowerment and quality of life. Interviews were analyzed using an interpretive description framework. RESULTS: Forty-eight participants completed the survey. The mean reported GYPES and PedsQL scores were 58.15 +/- 8.46 and 61.57 +/- 22.32, respectively. Theoretical sufficiency was reached after 14 interviews. Four environmental factors leading to feelings promoting empowerment were identified: (1) shared decision-making enabled advocacy and independence, (2) education (particularly involving genetics) increased knowledge and understanding, (3) sharing stories led to empowering others, and (4) participation in physical activities promoted a sense of belonging. CONCLUSIONS: This study was the first to use the GYPES in adolescents with diverse disabilities and/or chronic conditions from neurology and orthopedic clinics. Adolescent patients felt empowered when they were actively involved in their health care and informed about the genetics of their diagnosis. Participants also wanted opportunities to empower others going through similar experiences. This study emphasizes the need for access to genetic counseling and opportunities for shared expression to facilitate empowerment. CI - (c) 2026 The Author(s). FAU - Austin, Kennedy AU - Austin K AD - Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada. AD - BC Children's Hospital Research Institute, Vancouver, BC, Canada. FAU - Selby, Kathryn AU - Selby K AD - BC Children's Hospital Research Institute, Vancouver, BC, Canada. AD - Division of Neurology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada. FAU - Virani, Alice AU - Virani A AD - Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada. AD - Ethics Service, Provincial Health Services Authority, Vancouver, BC, Canada. FAU - Ross, Colin AU - Ross C AD - Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada. AD - BC Children's Hospital Research Institute, Vancouver, BC, Canada. AD - Centre for Advancing Health Outcomes, St Paul's Hospital, Vancouver, BC, Canada. AD - Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada. FAU - Chhina, Harpreet AU - Chhina H AD - Department of Orthopedics, University of British Columbia, Vancouver, BC, Canada. FAU - Cooper, Anthony AU - Cooper A AD - BC Children's Hospital Research Institute, Vancouver, BC, Canada. AD - Department of Orthopedics, University of British Columbia, Vancouver, BC, Canada. AD - Department of Orthopedics, BC Children's Hospital, Vancouver, BC, Canada. FAU - Elliott, Alison M AU - Elliott AM AD - Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada. AD - BC Children's Hospital Research Institute, Vancouver, BC, Canada. AD - Women's Health Research Institute, Vancouver, BC, Canada. LA - eng PT - Journal Article DEP - 20260606 PL - United States TA - J Pediatr Clin Pract JT - Journal of pediatrics. Clinical practice JID - 9918769578606676 PMC - PMC13352426 OTO - NOTNLM OT - adolescents OT - chronic condition OT - disability OT - empowerment COIS- K.A. was the recipient of the 10.13039/501100000024Canadian Institutes of Health Research (CIHR) Canadian Graduate Scholarship Master's award, through which this project was funded. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/11 06:35 MHDA- 2026/07/11 06:36 PMCR- 2026/06/06 CRDT- 2026/07/11 05:05 PHST- 2025/12/04 00:00 [received] PHST- 2026/05/26 00:00 [revised] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/07/11 06:36 [medline] PHST- 2026/07/11 06:35 [pubmed] PHST- 2026/07/11 05:05 [entrez] PHST- 2026/06/06 00:00 [pmc-release] AID - S2950-5410(26)00021-9 [pii] AID - 200220 [pii] AID - 10.1016/j.jpedcp.2026.200220 [doi] PST - epublish SO - J Pediatr Clin Pract. 2026 Jun 6;21:200220. doi: 10.1016/j.jpedcp.2026.200220. eCollection 2026 Oct. PMID- 42432606 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260911 IS - 1472-6823 (Electronic) IS - 1472-6823 (Linking) VI - 26 IP - 1 DP - 2026 Jul 10 TI - Predictive models of adverse outcomes of overweight or obesity: a nationwide cohort validation. LID - 10.1186/s12902-026-02399-4 [doi] LID - 265 AB - BACKGROUND: Obesity and overweight have a wide range of adverse clinical outcomes. Predictive models could help clinicians identify individuals with obesity and overweight at greater risk for obesity-related complications, enabling personalized shared decision-making about obesity treatment. We previously developed a set of predictive models of adverse clinical outcomes of obesity and overweight using electronic health record (EHR) data of a large health system in Massachusetts. However, these models have not been validated on data from other sources. METHODS: We validated 12 predictive models for cardiometabolic, oncologic and musculoskeletal complications of excess weight using a linked EHR and claims dataset of a national patient cohort (Optum((R)) Market Clarity) that included adults 18-80 years of age with body mass index (BMI) >/= 25 kg/m(2) between 2007 and 2023. RESULTS: A 5% randomly selected validation dataset included 437,223 patients (51.9% women) with a mean age of 51.4 years and a mean BMI of 31.9 kg/m(2) who were followed for a mean of 5.7 years. Most (11/12) models achieved Harrell C-index >/= 0.70. Most (11/12) models had either 5-year or 10-year calibration slope within 0.3 of the ideal value of 1.0; 7 out of 12 had either 5-year or 10-year calibration slope that was not significantly different from 1.0; all had intercepts very close to 0. CONCLUSIONS: A set of EHR-based predictive models of adverse outcomes of obesity and overweight was generalizable to a large national cohort. These findings suggest potential clinical and population health applications for predictive models in treatment of individual patients with obesity / overweight, as well as in population management and quality improvement. CLINICAL TRIAL NUMBER: Not applicable. CI - (c) 2026. The Author(s). FAU - Turchin, Alexander AU - Turchin A AUID- ORCID: 0000-0002-8609-564X AD - Brigham and Women's Hospital, Boston, MA, USA. aturchin@bwh.harvard.edu. AD - Harvard Medical School, Boston, MA, USA. aturchin@bwh.harvard.edu. FAU - Shubina, Maria AU - Shubina M AD - Brigham and Women's Hospital, Boston, MA, USA. FAU - Morrison, Fritha J AU - Morrison FJ AD - Brigham and Women's Hospital, Boston, MA, USA. FAU - Ahmad, Nadia N AU - Ahmad NN AD - Eli Lilly and Company, Indianapolis, IN, USA. FAU - Neff, Lisa M AU - Neff LM AD - Eli Lilly and Company, Indianapolis, IN, USA. FAU - Kan, Hong AU - Kan H AD - Eli Lilly and Company, Indianapolis, IN, USA. LA - eng PT - Journal Article PT - Validation Study DEP - 20260710 PL - England TA - BMC Endocr Disord JT - BMC endocrine disorders JID - 101088676 SB - IM MH - Humans MH - Female MH - *Obesity/complications/epidemiology MH - Middle Aged MH - *Overweight/complications/epidemiology MH - Male MH - Aged MH - Adult MH - Body Mass Index MH - Prognosis MH - Aged, 80 and over MH - Young Adult MH - Adolescent MH - Electronic Health Records/statistics & numerical data MH - Prediction Algorithms MH - Cohort Studies MH - Follow-Up Studies PMC - PMC13556077 OTO - NOTNLM OT - Long-term outcomes OT - Obesity OT - Overweight OT - Predictive modeling OT - Validation COIS- Declarations. Ethics approval and consent to participate: This study followed the principles outlined in the Helsinki Declaration. The study was approved by the Mass General Brigham institutional review board (protocol # 2021P003735), and the requirement for informed consent was waived. Consent for publication: Not applicable. Competing interests: Turchin reports consulting for Novo Nordisk and Proteomics International; research and travel support from Eli Lilly and Company; and research support from Novo Nordisk. Ahmad, Neff and Kan are employees and stockholders of Eli Lilly and Company. None of the other authors report any conflicts of interest. EDAT- 2026/07/11 05:37 MHDA- 2026/09/09 07:07 PMCR- 2026/07/10 CRDT- 2026/07/10 23:47 PHST- 2025/05/12 00:00 [received] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/09/09 07:07 [medline] PHST- 2026/07/11 05:37 [pubmed] PHST- 2026/07/10 23:47 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - 10.1186/s12902-026-02399-4 [pii] AID - 2399 [pii] AID - 10.1186/s12902-026-02399-4 [doi] PST - epublish SO - BMC Endocr Disord. 2026 Jul 10;26(1):265. doi: 10.1186/s12902-026-02399-4. PMID- 42432544 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261009 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 11 TI - Birth-size reference charts for normal nursery newborns between 35.0 and 41.6 weeks. LID - 10.1186/s12887-026-07275-7 [doi] LID - 960 AB - BACKGROUND: Current birth-size reference charts for nursery use may inaccurately categorize newborn size, impacting care. We aimed to develop new charts using data from uncomplicated newborns admitted to US nurseries. METHODS: We analyzed de-identified data from newborns admitted to US normal newborn nurseries between 2021 and 2024. Statistical outliers were excluded, and gestational age was recorded in days. Birth weight, length, head circumference, and BMI models were developed by a randomly selected subset and validated by the remaining data. Proportions of newborns below the 10th percentile and above the 90th percentile were compared with the 2010 Olsen and 2013 Fenton charts. RESULTS: Uncomplicated newborns born between 35.0 and 41.6 weeks of gestation were included. The new charts did not exhibit overfitting bias and more accurately identified the expected 10% of newborns below the 10th and above the 90th percentiles compared to existing charts. CONCLUSIONS: New charts (weight, length, head circumference, BMI) improve birth-size referencing in normal newborn nurseries. CI - (c) 2026. The Author(s). FAU - Chou, Fu-Sheng AU - Chou FS AUID- ORCID: 0000-0002-5770-0580 AD - Southern California Permanente Medical Group, Pasadena, CA, USA. Fu-Sheng.X.Chou@kp.org. AD - Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA. Fu-Sheng.X.Chou@kp.org. AD - Department of Clinical Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA, USA. Fu-Sheng.X.Chou@kp.org. AD - Department of Neonatology, Kaiser Permanente Riverside Medical Center, 10800 Magnolia Ave., Riverside, CA, 92505, USA. Fu-Sheng.X.Chou@kp.org. FAU - Yeh, Hung-Wen AU - Yeh HW AD - Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO, USA. AD - Department of Pediatrics, School of Medicine, University of Missouri-Kansas City, Kansas City, MO, USA. FAU - Hsueh, Crystal AU - Hsueh C AD - Psychobiology Program, University of California, Los Angeles, CA, USA. FAU - Olsen, Irene E AU - Olsen IE AD - Department of Nutrition Sciences, College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA. FAU - Tolia, Veeral N AU - Tolia VN AD - Center for Research, Education, Quality and Safety, Pediatrix Inc., Sunrise, FL, USA. FAU - Clark, Reese H AU - Clark RH AD - Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA. LA - eng PT - Journal Article DEP - 20260711 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Infant, Newborn MH - *Growth Charts MH - Reference Values MH - *Birth Weight MH - Gestational Age MH - Female MH - Male MH - Body Mass Index MH - Body Height MH - Cephalometry MH - Nurseries, Hospital PMC - PMC13644040 OTO - NOTNLM OT - Anthropometric measures OT - Growth charts OT - Newborn COIS- Declarations. Ethics approval and consent to participate: This data-only study with a deidentified dataset was deemed non-human research by the Institutional Review Board of Southern California Kaiser Permanente. As such, informed consent to participate was not required, including from the parents or legal guardians of any participant under the age of 16. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/11 05:37 MHDA- 2026/10/07 05:31 PMCR- 2026/07/11 CRDT- 2026/07/10 23:45 PHST- 2025/10/30 00:00 [received] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/10/07 05:31 [medline] PHST- 2026/07/11 05:37 [pubmed] PHST- 2026/07/10 23:45 [entrez] PHST- 2026/07/11 00:00 [pmc-release] AID - 10.1186/s12887-026-07275-7 [pii] AID - 7275 [pii] AID - 10.1186/s12887-026-07275-7 [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 11;26(1):960. doi: 10.1186/s12887-026-07275-7. PMID- 42431850 OWN - NLM STAT- Publisher LR - 20260710 IS - 1469-7610 (Electronic) IS - 0021-9630 (Linking) DP - 2026 Jul 10 TI - The longitudinal relationship among physical activity, social competence, and psychosomatic comorbidity patterns in adolescents: a cross-lagged panel analysis. LID - 10.1111/jcpp.70193 [doi] AB - BACKGROUND: Adolescents frequently experience psychosomatic comorbidities, yet longitudinal, bidirectional relationships among physical activity (PA), social competence (SC), and psychosomatic comorbidity (PC: mental health and sleep duration) remain underexplored in large non-Western samples. This study examined how PA and SC mutually influence PC over time and tested whether SC mediates the PA-PC link in Chinese high school students. METHODS: Data came from the National Adolescent Health Survey (China) collected from 2020 to 2023, matching participants by name at one-year intervals. The analytic sample (n = 9,680; 51.2% female, mean age = 15.89 +/- 1.06 years) completed validated measures. We tested measurement invariance, then estimated a two-wave cross-lagged panel model controlling for age, gender, residence, and only-child status. SC mediation was assessed via the product of cross-lagged paths with 1,000-sample bootstrap. Multiple-group SEM examined gender invariance. RESULTS: All measurement models achieved scalar invariance. Cross-lagged paths indicated PA(1) --> SC(2) (beta = 0.041, p < .001), PA(1) --> SD(2) (beta = 0.018, p < .05), and PA(1) --> MH(2) (beta = -0.023, p < .05). SC(1) --> MH(2) (beta = -0.034, p < .01). MH(1) --> PA(2) (beta = -0.038, p < .001), and SD(1) --> PA(2) (beta = 0.014, p < .05). Indirect effect PA(1) --> SC(2) --> PC(2) was significant (standardized = -0.001; 95% CI [-0.003, -0.001]). Gender group comparison showed no significant differences (Deltachi(2) (5) = 8.10, p = .16). CONCLUSIONS: PA and PC exert reciprocal influences in adolescents, with higher PA predicting improved SC, better SD, and reduced MH, while psychosomatic distress undermines subsequent PA and SC. SC partially mediates PA's protective effects on comorbidity, with equivalent patterns across genders. Interventions combining PA and social-skills training may disrupt the vicious cycle of adolescent PC. CI - (c) 2026 Association for Child and Adolescent Mental Health. FAU - Guo, Xinmeng AU - Guo X AUID- ORCID: 0000-0002-0432-6118 AD - School of Physical Education, Shandong University, Jinan, China. FAU - Yi, Nuo AU - Yi N AD - Physical medicine and rehabilitation, Christus Health, Canton, TX, USA. FAU - Lai, Xinxin AU - Lai X AD - School of Physical Education, Shandong University, Jinan, China. FAU - Yi, Xiangren AU - Yi X AD - School of Physical Education, Shandong University, Jinan, China. FAU - Dong, Xiaosheng AU - Dong X AUID- ORCID: 0000-0003-0507-2938 AD - School of Physical Education, Shandong University, Jinan, China. AD - Department of Social Medicine and Health Management, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China. AD - NHC Key Lab of Health Economics and Policy Research (Shandong University), Jinan, China. AD - Center for Health Management and Policy Research, Shandong University (Shandong Provincial Key New Think Tank), Jinan, China. LA - eng PT - Journal Article DEP - 20260710 PL - England TA - J Child Psychol Psychiatry JT - Journal of child psychology and psychiatry, and allied disciplines JID - 0375361 SB - IM OTO - NOTNLM OT - Physical activity OT - adolescents OT - cross-lagged model OT - psychosomatic comorbidity OT - social competence EDAT- 2026/07/11 05:39 MHDA- 2026/07/11 05:39 CRDT- 2026/07/10 23:03 PHST- 2026/06/04 00:00 [accepted] PHST- 2026/07/11 05:39 [medline] PHST- 2026/07/11 05:39 [pubmed] PHST- 2026/07/10 23:03 [entrez] AID - 10.1111/jcpp.70193 [doi] PST - aheadofprint SO - J Child Psychol Psychiatry. 2026 Jul 10. doi: 10.1111/jcpp.70193. PMID- 42431813 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20260921 IS - 2352-7226 (Electronic) IS - 2352-7218 (Linking) VI - 12 IP - 5 DP - 2026 Oct TI - Sleep problems and underweight among adolescent girls and adult women aged 12-49 years: A cross-sectional, web-based survey in Japan. PG - 778-785 LID - S2352-7218(26)00127-0 [pii] LID - 10.1016/j.sleh.2026.06.005 [doi] AB - OBJECTIVES: Underweight is a common health concern among individuals of reproductive age. Although sleep and metabolic regulation share neuroendocrine pathways, the relationship between underweight and sleep problems remains unclear. This study aimed to investigate the associations between underweight and questionnaire-based sleep-related outcomes among adolescent girls and adult women. METHODS: These cross-sectional, web-based surveys were conducted from November to December 2023 among adolescent girls (aged 12-18 years) and adult women aged 18 to 49 years. Valid responses were obtained from 996 adolescent girls and 4689 adult women. Logistic regression analyses were conducted within age-defined subgroups to examine associations between weight categories and sleep-related outcomes, including a sleep debt-related pattern with daytime sleepiness and self-reported insomnia symptoms, adjusting for sociodemographic and lifestyle factors. RESULTS: Among respondents, 14.7% of adolescent girls and 23.5% of adult women were underweight. Underweight was not associated with either of the sleep-related outcomes among adolescent girls. In adult women, underweight was associated with self-reported insomnia symptoms in women in their 20s, with no associations observed in other age groups. An interaction between age and underweight was observed, suggesting that this association weakened with increasing age. CONCLUSIONS: Underweight was associated with self-reported insomnia symptoms, but not with a sleep debt-related pattern with daytime sleepiness, among adult women in their 20s. These findings suggest that sleep assessment may be considered as part of comprehensive strategies addressing underweight, although further studies using validated sleep measures are needed. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Kayaba, Momoko AU - Kayaba M AD - International Institute for Integrative Sleep Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan. Electronic address: momoko.kayaba@gmail.com. FAU - Ogata, Hitomi AU - Ogata H AD - Graduate School of Humanities and Social Sciences, Hiroshima University, Hiroshima, Japan. FAU - Yumen, Yukina AU - Yumen Y AD - Graduate school of Human Science and Environment, University of Hyogo, Himeji, Hyogo, Japan. FAU - Takayama, Yumi AU - Takayama Y AD - Graduate school of Human Science and Environment, University of Hyogo, Himeji, Hyogo, Japan. FAU - Kiyono, Ken AU - Kiyono K AD - Graduate School of Engineering Science, The University of Osaka, Toyonaka, Osaka, Japan. FAU - Nose-Ogura, Sayaka AU - Nose-Ogura S AD - Department of Sport Medicine and Research, Japan Institute Sports Sciences, Japan High-Performance Sport Center, kita-ku, Tokyo, Japan. FAU - Nagai, Narumi AU - Nagai N AD - Graduate school of Human Science and Environment, University of Hyogo, Himeji, Hyogo, Japan. LA - eng PT - Journal Article DEP - 20260711 PL - United States TA - Sleep Health JT - Sleep health JID - 101656808 SB - IM MH - *Sleep Initiation and Maintenance Disorders MH - *Thinness/epidemiology MH - Japan/epidemiology MH - Cross-Sectional Studies MH - Humans MH - Male MH - Female MH - Child MH - Adolescent MH - Young Adult MH - Adult OTO - NOTNLM OT - Adolescent girls OT - Adult women OT - Reproductive age OT - Sleep OT - Underweight COIS- Declaration of conflicts of interest The authors have declared no conflicts of interest. EDAT- 2026/07/11 05:37 MHDA- 2026/09/17 23:34 CRDT- 2026/07/10 21:53 PHST- 2025/11/06 00:00 [received] PHST- 2026/06/18 00:00 [revised] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/09/17 23:34 [medline] PHST- 2026/07/11 05:37 [pubmed] PHST- 2026/07/10 21:53 [entrez] AID - S2352-7218(26)00127-0 [pii] AID - 10.1016/j.sleh.2026.06.005 [doi] PST - ppublish SO - Sleep Health. 2026 Oct;12(5):778-785. doi: 10.1016/j.sleh.2026.06.005. Epub 2026 Jul 11. PMID- 42431596 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260901 IS - 1938-3207 (Electronic) IS - 0002-9165 (Linking) VI - 124 IP - 3 DP - 2026 Sep TI - Maternal Intake of Vitamins A, C, D, and E During Pregnancy and Risk of Type 1 Diabetes in the Child: The Norwegian Mother, Father, and Child Cohort Study. PG - 101431 LID - S0002-9165(26)00240-6 [pii] LID - 10.1016/j.ajcnut.2026.101431 [doi] AB - BACKGROUND: Dietary vitamins play a role in antioxidant defense and immunoregulation. However, prospective studies exploring the association between vitamin intakes during pregnancy and the child's risk of type 1 diabetes are limited. OBJECTIVES: This population-based prospective cohort study aimed to investigate the association between maternal intake of vitamins A, C, D, and E during pregnancy and risk of type 1 diabetes in children. METHODS: We included 85,244 children born between 2002 and 2009 in the Norwegian Mother and Child Cohort Study, with follow-up until 31 December, 2021. Maternal intake of vitamins from food and dietary supplements from conception to the 22nd week of pregnancy was assessed with a validated food frequency questionnaire. Cox proportional hazards regression was used to estimate hazard ratios (HRs), adjusting for background factors. RESULTS: During follow-up, 529 (0.6%) children were diagnosed with type 1 diabetes at a mean age of 9.4 y (standard deviation: 4.1 y) No associations were observed between maternal pregnancy intake of vitamin A [HR: 0.993; 95% confidence interval (CI): 0.983, 1.003/100 mug], vitamin C (HR: 1.000; 95% CI: 0.993, 1.007/10 mg), vitamin D (HR: 0.991; 95% CI: 0.978, 1.003/1 mug), or vitamin E (HR: 0.999; 95% CI: 0.996, 1.004/10 mg) and risk of type 1 diabetes in the child when adjusted for potential confounders. The results were similar when intakes were assessed separately from food and dietary supplements and after restriction to children with human leukocyte antigen DQ2 and/or DQ8 risk haplotypes. CONCLUSIONS: This prospective cohort study does not support the hypothesis that higher maternal intake of vitamins A, C, D, and E during pregnancy would decrease risk of type 1 diabetes in the child. Corroborated with previous evidence, our findings support a general pattern of null associations. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Mattila, Markus AU - Mattila M AD - Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, Finland; Wellbeing Services County of Pirkanmaa, Tampere University Hospital, Tampere, Finland; Department of Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland; Centre for Child, Adolescent and Maternal Health Research (TamCM), Tampere University, Tampere, Finland. Electronic address: markus.mattila@tuni.fi. FAU - Tapia, German AU - Tapia G AD - Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway. FAU - Stordal, Ketil AU - Stordal K AD - Department of Pediatric Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway. FAU - Brantsaeter, Anne-Lise AU - Brantsaeter AL AD - Department of Food Safety, Norwegian Institute of Public Health, Oslo, Norway; Centre for Sustainable Diets, Norwegian Institute of Public Health, Oslo, Norway. FAU - Virtanen, Suvi M AU - Virtanen SM AD - Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, Finland; Wellbeing Services County of Pirkanmaa, Tampere University Hospital, Tampere, Finland; Centre for Child, Adolescent and Maternal Health Research (TamCM), Tampere University, Tampere, Finland; Department of Pediatrics, Tampere University Hospital, Tampere, Finland. FAU - Lund-Blix, Nicolai A AU - Lund-Blix NA AD - The Norwegian Childhood Diabetes Registry, Division of Childhood and Adolescent Medicine, Oslo University Hospital, Oslo, Norway. FAU - Skrivarhaug, Torild AU - Skrivarhaug T AD - Department of Food Safety, Norwegian Institute of Public Health, Oslo, Norway; Centre for Sustainable Diets, Norwegian Institute of Public Health, Oslo, Norway; The Norwegian Childhood Diabetes Registry, Division of Childhood and Adolescent Medicine, Oslo University Hospital, Oslo, Norway; Oslo Diabetes Research Centre, Oslo University Hospital, Oslo, Norway. FAU - Hard Af Segerstad, Elin M AU - Hard Af Segerstad EM AD - Pediatric Research Institute, Oslo University Hospital, Oslo, Norway; Unit of Celiac Disease and Diabetes, Clinical Sciences Malmo, Lund University, Malmo, Sweden. FAU - Stene, Lars C AU - Stene LC AD - Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway; Oslo Diabetes Research Centre, Oslo University Hospital, Oslo, Norway. CN - HEDIMED Investigator Group LA - eng PT - Journal Article DEP - 20260710 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 RN - 0 (Vitamins) RN - 11103-57-4 (Vitamin A) RN - 1406-16-2 (Vitamin D) RN - 1406-18-4 (Vitamin E) RN - PQ6CK8PD0R (Ascorbic Acid) SB - IM MH - Humans MH - Female MH - *Diabetes Mellitus, Type 1/epidemiology/prevention & control MH - Pregnancy MH - Norway/epidemiology MH - Prospective Studies MH - Child MH - Dietary Supplements MH - Male MH - *Vitamins/administration & dosage MH - Vitamin A/administration & dosage MH - Vitamin D/administration & dosage MH - Vitamin E/administration & dosage MH - *Maternal Nutritional Physiological Phenomena MH - Adult MH - Ascorbic Acid/administration & dosage MH - Cohort Studies MH - Risk Factors OTO - NOTNLM OT - MoBa OT - diabetes mellitus OT - diet OT - dietary supplements OT - observational study OT - pregnancy OT - type 1 OT - vitamins COIS- Conflict of interest The authors report no conflicts of interest. FIR - Kristi, Hoffman IR - Kristi H IRAD- Baylor College of Medicine, Department of Molecular Virology and Microbiology. FIR - Sara, Javornik Cregeen IR - Sara JC IRAD- Baylor College of Medicine, Department of Molecular Virology and Microbiology. FIR - Joseph, Petrosino IR - Joseph P IRAD- Baylor College of Medicine, Department of Molecular Virology and Microbiology. FIR - Tasha, Santiago Rodriguez IR - Tasha SR IRAD- Baylor College of Medicine, Department of Molecular Virology and Microbiology. FIR - Ondrej, Cinek IR - Ondrej C IRAD- Charles University, 2nd Faculty of Medicine. FIR - Eva, Fronkova IR - Eva F IRAD- Charles University, 2nd Faculty of Medicine. FIR - Hans, Bisgaard IR - Hans B IRAD- COPSAC. FIR - Klaus, Bonnelykke IR - Klaus B IRAD- COPSAC. FIR - Sarah, Brandt IR - Sarah B IRAD- COPSAC. FIR - Astrid, Sevelsted IR - Astrid S IRAD- COPSAC. FIR - Shiraz, Shah IR - Shiraz S IRAD- COPSAC. FIR - Jakob, Stokholm IR - Jakob S IRAD- COPSAC. FIR - Jonathan, Thorsen IR - Jonathan T IRAD- COPSAC. FIR - Jaroslav, Havlik IR - Jaroslav H IRAD- Czech University of Life Sciences Prague, Department of Food Science. FIR - Eliska, Jenickova IR - Eliska J IRAD- Czech University of Life Sciences Prague, Department of Food Science. FIR - Daniel, Schmidtmann IR - Daniel S IRAD- Empirica. FIR - Rainer, Thiel IR - Rainer T IRAD- Empirica. FIR - Leena, Hakola IR - Leena H IRAD- Finnish Institute for Health and Welfare, The Department of Health Security and The Department of Public Health and Welfare. FIR - Hannu, Kiviranta IR - Hannu K IRAD- Finnish Institute for Health and Welfare, The Department of Health Security and The Department of Public Health and Welfare. FIR - Panu, Rantakokko IR - Panu R IRAD- Finnish Institute for Health and Welfare, The Department of Health Security and The Department of Public Health and Welfare. FIR - Suvi M, Virtanen IR - Suvi M V IRAD- Finnish Institute for Health and Welfare, The Department of Health Security and The Department of Public Health and Welfare. FIR - Alexander, Berler IR - Alexander B IRAD- Gnomon. FIR - Apostolia, Karabatea IR - Apostolia K IRAD- Gnomon. FIR - Korina, Papadopoulou IR - Korina P IRAD- Gnomon. FIR - Gabriele, Berg IR - Gabriele B IRAD- Graz University of Technology, Institute of Environmental Biotechnology. FIR - Wisnu, Wicaksono IR - Wisnu W IRAD- Graz University of Technology, Institute of Environmental Biotechnology. FIR - Daniel, Agardh IR - Daniel A IRAD- Lund University, Department of Clinical Sciences. FIR - Andren, Aronsson Carin IR - Andren AC IRAD- Lund University, Department of Clinical Sciences. FIR - Markus, Lundgren IR - Markus L IRAD- Lund University, Department of Clinical Sciences. FIR - Bostrom, Michaela IR - Bostrom M IRAD- Lund University, Department of Clinical Sciences. FIR - Marja, Roslund IR - Marja R IRAD- Natural Resources Institute Finland, Horticulture Technologies. FIR - Aki, Sinkkonen IR - Aki S IRAD- Natural Resources Institute Finland, Horticulture Technologies. FIR - Sara, Alibakhshi IR - Sara A IRAD- Satellio. FIR - Lauri, Hame IR - Lauri H IRAD- Satellio. FIR - Patricia-Daiana, Boia IR - Patricia-Daiana B IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Loic, Burr IR - Loic B IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Stefano, Cattaneo IR - Stefano C IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Peter, Cristofollini IR - Peter C IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Silvia, Demuru IR - Silvia D IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Silvia, Generelli IR - Silvia G IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Nicola, Hermann IR - Nicola H IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Hui, Chai-Gao IR - Hui CG IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Samantha, Paoletti IR - Samantha P IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Bradley, Petkus IR - Bradley P IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Edith, Ruth IR - Edith R IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Yevhen, Shynkarenko IR - Yevhen S IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Erika, Antola IR - Erika A IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Anna, Euren IR - Anna E IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Heikki, Hyoty IR - Heikki H IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Nanna, Kangasmaki IR - Nanna K IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Laura, Kivela IR - Laura K IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Kalle, Kurppa IR - Kalle K IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Jutta, Laiho IR - Jutta L IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Olli, Laitinen IR - Olli L IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Jussi, Lehtonen IR - Jussi L IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Jake, Lin IR - Jake L IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Katri, Lindfors IR - Katri L IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Maria, Lonnrot IR - Maria L IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Johannes, Malkamaki IR - Johannes M IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Jani, Makinen IR - Jani M IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Henna, Numminen IR - Henna N IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Noora, Nurminen IR - Noora N IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Matti, Nykter IR - Matti N IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Sami, Oikarinen IR - Sami O IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Maarit, Oikarinen IR - Maarit O IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Tiina, Palmu IR - Tiina P IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Leena, Puustinen IR - Leena P IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Niila, Saarinen IR - Niila S IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Erika, Seppala IR - Erika S IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Miia, Siljavaara IR - Miia S IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Amirbabak, Sioofy-Khojine IR - Amirbabak SK IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Minna, Turppa IR - Minna T IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Keijo, Viiri IR - Keijo V IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Mikael, Knip IR - Mikael K IRAD- Tampere University Hospital. FIR - Aleksandr, Peet IR - Aleksandr P IRAD- Tartu University Hospital. FIR - Kart, Simre IR - Kart S IRAD- Tartu University Hospital. FIR - Vallo, Tillmann IR - Vallo T IRAD- Tartu University Hospital. FIR - Elin, Hard Af Segerstad IR - Elin HAS IRAD- The Norwegian Institute of Public Health. FIR - Nicolai A, Lund-Blix IR - Nicolai A LB IRAD- The Norwegian Institute of Public Health. FIR - Maria, Magnus IR - Maria M IRAD- The Norwegian Institute of Public Health. FIR - Aino-Kaisa, Rantala IR - Aino-Kaisa R IRAD- The Norwegian Institute of Public Health. FIR - Lars, Stene IR - Lars S IRAD- The Norwegian Institute of Public Health. FIR - Ketil, Stordal IR - Ketil S IRAD- The Norwegian Institute of Public Health. FIR - German, Tapia IR - German T IRAD- The Norwegian Institute of Public Health. FIR - Iida, Makela IR - Iida M IRAD- University of Helsinki, Faculty of Biological and Environmental Sciences. FIR - Martin, Romantschuk IR - Martin R IRAD- University of Helsinki, Faculty of Biological and Environmental Sciences. FIR - Laura, Soininen IR - Laura S IRAD- University of Helsinki, Faculty of Biological and Environmental Sciences. FIR - Tiia, Honkanen IR - Tiia H IRAD- University of Oulu, Department of Paediatrics. FIR - Juho, Pietila IR - Juho P IRAD- University of Oulu, Department of Paediatrics. FIR - Nelli, Ronka IR - Nelli R IRAD- University of Oulu, Department of Paediatrics. FIR - Toni, Valtanen IR - Toni V IRAD- University of Oulu, Department of Paediatrics. FIR - Riitta, Veijola IR - Riitta V IRAD- University of Oulu, Department of Paediatrics. FIR - Elena, Bargagli IR - Elena B IRAD- University of Siena, Department of Medicine, Surgery and Neuroscience. FIR - Francesco, Dotta IR - Francesco D IRAD- University of Siena, Department of Medicine, Surgery and Neuroscience. FIR - Laura, Nigi IR - Laura N IRAD- University of Siena, Department of Medicine, Surgery and Neuroscience. FIR - Guido, Sebastiani IR - Guido S IRAD- University of Siena, Department of Medicine, Surgery and Neuroscience. FIR - Alar, Aints IR - Alar A IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Kristi, Alnek IR - Kristi A IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Anu, Barenson IR - Anu B IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Anne, Kirss IR - Anne K IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Ivo, Laidmae IR - Ivo L IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Astrid, Oras IR - Astrid O IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Aili, Tagoma IR - Aili T IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Raivo, Uibo IR - Raivo U IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Tamara, Vorobjova IR - Tamara V IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Iltana, Bojovic IR - Iltana B IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Laura, Elo IR - Laura E IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Karoliina, Hirvonen IR - Karoliina H IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Sini, Junttila IR - Sini J IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Jalmari, Kettunen IR - Jalmari K IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Riitta, Lahesmaa IR - Riitta L IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Johanna, Lempainen IR - Johanna L IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Robert, Moulder IR - Robert M IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Omid, Rasool IR - Omid R IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Inna, Starskaia IR - Inna S IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Tomi, Suomi IR - Tomi S IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Jorma, Toppari IR - Jorma T IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Ubaid, Ullah IR - Ubaid U IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Barannik, Emilia IR - Barannik E IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Jean Eudes, Gbodjo Yawogan IR - Jean Eudes GY IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Matthieu, Molinier IR - Matthieu M IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Tarja, Nevanen IR - Tarja N IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Juha, Pajula IR - Juha P IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Juha, Parkka IR - Juha P IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Jukka, Ranta IR - Jukka R IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Jyri, Rokman IR - Jyri R IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Petri, Saviranta IR - Petri S IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Peter, Ylen IR - Peter Y IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Eija, Parmes IR - Eija P IRAD- VTT Technical Research Centre of Finland Ltd. EDAT- 2026/07/11 05:37 MHDA- 2026/09/01 23:34 CRDT- 2026/07/10 19:17 PHST- 2026/03/17 00:00 [received] PHST- 2026/07/04 00:00 [revised] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/09/01 23:34 [medline] PHST- 2026/07/11 05:37 [pubmed] PHST- 2026/07/10 19:17 [entrez] AID - S0002-9165(26)00240-6 [pii] AID - 10.1016/j.ajcnut.2026.101431 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Sep;124(3):101431. doi: 10.1016/j.ajcnut.2026.101431. Epub 2026 Jul 10. PMID- 42431240 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260907 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 227 DP - 2026 Dec 1 TI - Associations between the residential food environment and diet: The Generation R Study. PG - 108717 LID - S0195-6663(26)00279-5 [pii] LID - 10.1016/j.appet.2026.108717 [doi] AB - The neighbourhood food environment is a potentially modifiable determinant of children's diets, yet evidence for associations with dietary outcomes remains mixed. This study examined cross-sectional associations between residential food environment characteristics and dietary outcomes among 8-year-old Dutch children, and whether maternal education (indicating household socioeconomic status) moderated these associations. Data were drawn from (n = 3739) children in the Generation R Study, a population-based birth cohort in Rotterdam, the Netherlands. Residential food environment exposure was assessed using Geographic Information System-based measures of absolute and relative fast-food outlet density and an overall neighbourhood food environment healthiness score within 400m from children's residences. Dietary outcomes were derived from a parent-reported Food Frequency Questionnaire, and included a validated overall diet quality score (out of 10), and non-core food and drink intake (g/day). Associations were examined using generalized linear models, adjusting for potential confounders. Findings revealed limited and unexpected associations. A healthier food environment score was associated with children's poorer diet quality, and no interaction with maternal education was found. Greater absolute fast-food outlet exposure was associated with better diet quality, but only among children with higher-educated mothers (+0.021 point/outlet, 95% CI: 0.008, 0.034). No associations were found between relative fast-food outlet density and any dietary outcomes. No consistent associations were found for food environment exposure and non-core food and drink intake. In the urban Dutch context, neighbourhood food environments showed weak and inconsistent associations with child diet, with some evidence of potential moderation by household socioeconomic status. These findings highlight the need for multidimensional research and intervention strategies that consider family resources and cultural context to effectively support healthy eating among children. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Harris, Holly A AU - Harris HA AD - Erasmus University Rotterdam, Department of Psychology, Education & Child Studies, Rotterdam, the Netherlands; Sydney Nursing School, Faculty of Medicine and Health, Discipline of Nutrition and Dietetics, The University of Sydney, Sydney, New South Wales, Australia; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia. FAU - Molenberg, Famke J M AU - Molenberg FJM AD - Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands. FAU - Jansen, Wilma AU - Jansen W AD - Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands; City of Rotterdam, Department of Social Development, Rotterdam, the Netherlands. FAU - Kocken, Paul AU - Kocken P AD - Erasmus University Rotterdam, Department of Psychology, Education & Child Studies, Rotterdam, the Netherlands. FAU - Voortman, Trudy AU - Voortman T AD - Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, the Netherlands. FAU - Jansen, Pauline W AU - Jansen PW AD - Erasmus University Rotterdam, Department of Psychology, Education & Child Studies, Rotterdam, the Netherlands; Department of Child & Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. Electronic address: p.w.jansen@erasmusmc.nl. LA - eng PT - Journal Article DEP - 20260710 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - Netherlands MH - Child MH - Male MH - Cross-Sectional Studies MH - *Residence Characteristics MH - *Diet MH - *Neighborhood Characteristics MH - Fast Foods MH - Educational Status MH - Socioeconomic Factors MH - Surveys and Questionnaires MH - *Diet, Healthy MH - Geographic Information Systems MH - Mothers MH - *Food Supply MH - Feeding Behavior MH - Birth Cohort OTO - NOTNLM OT - Child OT - Diet quality OT - Fast-food exposure OT - Geographic information systems (GIS) OT - Neighbourhood food environment OT - Non-core food OT - Socioeconomic status COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/11 05:37 MHDA- 2026/09/07 23:34 CRDT- 2026/07/10 19:11 PHST- 2025/08/25 00:00 [received] PHST- 2026/06/22 00:00 [revised] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/09/07 23:34 [medline] PHST- 2026/07/11 05:37 [pubmed] PHST- 2026/07/10 19:11 [entrez] AID - S0195-6663(26)00279-5 [pii] AID - 10.1016/j.appet.2026.108717 [doi] PST - ppublish SO - Appetite. 2026 Dec 1;227:108717. doi: 10.1016/j.appet.2026.108717. Epub 2026 Jul 10. PMID- 42430046 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260904 IS - 1475-1313 (Electronic) IS - 0275-5408 (Linking) VI - 46 IP - 5 DP - 2026 Sep TI - Analysis of the Association Between Weight Status and Myopia in Children and Adolescents and Development of a Screening Model Based on Body Fat Percentage. PG - 1040-1048 LID - 10.1007/s44402-026-00135-y [doi] AB - PURPOSE: This study examined the association between weight status and myopia in children and adolescents and compared the screening performance of body mass index (BMI) and body fat percentage. METHODS: This cross-sectional study included 8748 students aged 7-15 years. Height, weight and body fat percentage were measured, and myopia was assessed using non-cycloplegic autorefraction. The sample was randomly divided into training and validation sets. Logistic regression adjusted for sex, age, residence, physical activity and outdoor light exposure was used to examine the association between weight status and myopia. Mediation analysis treated physical activity as a categorical variable, with bootstrap resampling used to test indirect effects through BMI and body fat percentage. Receiver operating characteristic curves compared the screening performance of both indicators. RESULTS: Overweight or obesity was associated with myopia after full adjustment (odds ratio = 1.45, 95% confidence interval: 1.30-1.63). Categorical mediation analysis showed a direct protective association of higher physical activity with myopia, with no significant indirect effect through BMI or body fat percentage. In both training and validation sets, the area under the curve was 0.76 for BMI and 0.76 for body fat percentage. A body fat percentage threshold of 0.69 classified a high-risk group with higher myopia prevalence than the low-risk group (88.7% versus 52.1%). CONCLUSION: Overweight or obesity is independently associated with myopia. BMI and body fat percentage provide comparable, low-cost tools for initial school-based risk stratification, while physical activity may protect against myopia independently of body composition. CI - (c) 2026. The Author(s), under exclusive licence to The College of Optometrists. FAU - Zhao, Deqiang AU - Zhao D AD - China Institute of Sport Science, Beijing, China. FAU - Chen, Xiaoxiao AU - Chen X AD - School of Physical Education and Sports Rehabilitation, Jinzhou Medical University, Jinzhou, China. FAU - Zhang, Aoyu AU - Zhang A AD - Tianshi College of Tianjin, School of Medicine, Tianjin, China. FAU - Pan, Xiang AU - Pan X AD - Graduate School of Health and Sports Science, Juntendo University, Inzai, Japan. FAU - Wang, Chunmiao AU - Wang C AD - China Institute of Sport Science, Beijing, China. FAU - Chen, Jiaxin AU - Chen J AD - China Institute of Sport Science, Beijing, China. FAU - Hu, Haixia AU - Hu H AD - Aiyoudong Children and Youth Sports Health Research Institute, Weifang, China. FAU - Zhang, Yanfeng AU - Zhang Y AD - China Institute of Sport Science, Beijing, China. zhangyanfeng0310@126.com. LA - eng GR - 2022YFC3600204/Special Project on "Scientific and Technological Countermeasures for Positive Health and Population Aging" under the National Key Research and Development Program of China/ GR - B2311/Weifang Integration of Sports and Health Innovation and Development Project/ GR - B2422/Weifang Children and Adolescents Sports-Health Integration Innovation and Development Initiative/ PT - Journal Article DEP - 20260710 PL - England TA - Ophthalmic Physiol Opt JT - Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) JID - 8208839 SB - IM MH - Humans MH - Child MH - Female MH - Adolescent MH - *Myopia/epidemiology/physiopathology/diagnosis/etiology MH - Cross-Sectional Studies MH - Male MH - Body Mass Index MH - *Adipose Tissue MH - ROC Curve MH - Risk Factors MH - *Overweight/complications MH - Prevalence MH - *Body Weight/physiology OTO - NOTNLM OT - Body fat percentage OT - Children and adolescents OT - Myopia OT - Overweight and obesity OT - ROC curve OT - Screening model COIS- Competing Interests: The authors declare no competing interests. Consent to Publish Declaration: This study was conducted in accordance with the Declaration of Helsinki and was approved by the Institutional Review Board of the China Institute of Sport Science (Approval No. CISSLA20230110). Written informed consent was obtained from the guardians of all participating children and the children themselves provided assent. Ethics and Consent to Participate Declarations: All guardians of the subjects participating in the study have signed the informed consent form. Institutional Review Board statement: This study was conducted in accordance with the Declaration of Helsinki and was approved by the Institutional Review Board of the Chinese Institute of Sport Science (No. CISSLA20230110). EDAT- 2026/07/10 12:44 MHDA- 2026/09/04 17:40 CRDT- 2026/07/10 11:20 PHST- 2025/12/18 00:00 [received] PHST- 2026/06/20 00:00 [accepted] PHST- 2026/06/18 00:00 [revised] PHST- 2026/09/04 17:40 [medline] PHST- 2026/07/10 12:44 [pubmed] PHST- 2026/07/10 11:20 [entrez] AID - 10.1007/s44402-026-00135-y [pii] AID - 10.1007/s44402-026-00135-y [doi] PST - ppublish SO - Ophthalmic Physiol Opt. 2026 Sep;46(5):1040-1048. doi: 10.1007/s44402-026-00135-y. Epub 2026 Jul 10. PMID- 42429973 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20261008 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 8 DP - 2026 Jul 10 TI - A multivariate electrocardiographic predictive model for left ventricular hypertrophy in children with primary hypertension. LID - 569 [pii] LID - 10.1007/s00431-026-07198-6 [doi] AB - Current electrocardiographic (ECG) criteria are of low diagnostic value compared with echocardiography (ECHO) for LVH, establishing a more effective ECG predictive model is required. The research purpose was to establish and validate a model to improve the diagnostic capability of ECG for LVH in pediatric primary hypertension. A retrospective study of 502 hypertensive children were recruited in the study between January 2019 and December 2024. The cohort were randomly divided into training (n = 402) and test sets (n = 100) with a proportion of 8:2. LVH was diagnosed using ECHO criteria. A total of 22 ECG parameters were evaluated. A predictive nomogram was developed using least absolute shrinkage and selection operator (LASSO) and multivariate logistic regression. LVH was identified in 117 (29.1%) of the training set and 29 (29.0%) of the test set. Body mass index (BMI), R(I) + S(V4), and S(D) + S(V4) were identified as independent predictors of LVH. The nomogram model showed good performance, with an area under the curve (AUC) of 0.822 in the training set and 0.803 in the test set. Calibration curves and Hosmer-Lemeshow test indicated good agreement between predicted and actual probabilities. DCA demonstrated clinical usefulness. The model outperformed previous models, as confirmed by NRI and IDI. CONCLUSIONS: The nomogram model incorporating BMI, R(I) + S(V4), and S(D) + S(V4) significantly improves the ECG diagnosis of LVH in pediatric primary hypertension, serving as a reliable tool for early LVH detection in hypertensive children. WHAT IS KNOWN: * We established a pediatric-specific nomogram integrating BMI and two composite ECG indices (R(I) + S(V4), S(D) + S(V4)); this model outperforms conventional adult ECG criteria and exhibits reliable discrimination, calibration and clinical practicability for diagnosing LVH in children with primary hypertension diagnosing LVH in children with primary hypertension. * This work innovatively uses BMI as a correction term to compensate for ECG voltage attenuation induced by chest wall fat in obese children, substantially lifting the overall ECG diagnostic accuracy of pediatric hypertensive LVH. WHAT IS NEW: * Our current study developed a nomogram model combining BMI, RI + SV4, and SD + SV4 that significantly improves ECG diagnostic accuracy for LVH in children with primary hypertension. * The research innovatively transforms BMI into a corrective factor addressing voltage attenuation caused by chest wall fat in obese children. * The model identifies pediatric-specific composite ECG indices superior to adult-derived criteria, demonstrating good discrimination, calibration, and clinical utility. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Liu, Yang AU - Liu Y AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. FAU - Cui, Yaxi AU - Cui Y AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. FAU - Lin, Yao AU - Lin Y AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. FAU - Zheng, Tong AU - Zheng T AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. FAU - Bao, Min AU - Bao M AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. FAU - Liu, Yanyan AU - Liu Y AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. FAU - Jiang, He AU - Jiang H AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. FAU - Shi, Lin AU - Shi L AUID- ORCID: 0000-0001-7578-7440 AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. shilin9789@126.com. LA - eng GR - YJRC202401/Research Start-up Fund for Introduced Talents of Capital Institute of Pediatrics/ GR - YGLX202532/Beijing Hospitals Authority Clinical medicine Development of special funding support/ GR - XZYB-2025-01/New Quality Fund of Capital Institute of Pediatrics/ PT - Journal Article DEP - 20260710 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Electrocardiography/methods MH - *Hypertrophy, Left Ventricular/diagnosis/etiology MH - Retrospective Studies MH - Child MH - *Nomograms MH - Female MH - Male MH - Predictive Value of Tests MH - *Essential Hypertension/complications MH - Adolescent MH - Multivariate Analysis MH - *Hypertension/complications MH - Echocardiography MH - Logistic Models OTO - NOTNLM OT - Children OT - Echocardiography OT - Electrocardiography OT - Hypertension OT - Left ventricular hypertrophy OT - Predictive model COIS- Declarations. Ethics approval: This study had approval from the Ethic Committee of the Capital Center for Children's Health, Capital Medical University (No: SHERLL2025011). Each child's parent or legal guardian/next of kin provided signed informed consent. This study was performed in line with the principles of the Declaration of Helsinki and its later amendments. Consent to participate: All participants gave their written consent to participate. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/10 12:46 MHDA- 2026/07/11 01:09 CRDT- 2026/07/10 11:15 PHST- 2026/03/19 00:00 [received] PHST- 2026/06/20 00:00 [accepted] PHST- 2026/05/29 00:00 [revised] PHST- 2026/07/11 01:09 [medline] PHST- 2026/07/10 12:46 [pubmed] PHST- 2026/07/10 11:15 [entrez] AID - 10.1007/s00431-026-07198-6 [pii] AID - 10.1007/s00431-026-07198-6 [doi] PST - epublish SO - Eur J Pediatr. 2026 Jul 10;185(8):569. doi: 10.1007/s00431-026-07198-6. PMID- 42429723 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260826 IS - 2405-5018 (Electronic) IS - 2405-500X (Print) IS - 2405-500X (Linking) VI - 12 IP - 8 DP - 2026 Aug TI - Beta-Blockers and Exercise Performance in Children With Long QT Syndrome. PG - 2010-2018 LID - S2405-500X(26)00558-X [pii] LID - 10.1016/j.jacep.2026.06.010 [doi] AB - BACKGROUND: Young people taking beta-blockers for long QT syndrome (LQTS) have concerns about exercise performance. OBJECTIVES: This study sought to determine whether objective measures of cardiopulmonary fitness are influenced by beta-blocker dose in LQTS. METHODS: In a retrospective chart review of treadmill cardiopulmonary exercise tests (CPETs), we measured peak oxygen consumption (Vo(2)), respiratory exchange ratio (RER), blood pressure, and percent predicted heart rate at peak exertion (%PHR), each analyzed with a linear mixed-effects model. We analyzed nadolol data (noncardioselective) as our primary analysis, then analyzed a validation cohort of atenolol data (cardioselective). RESULTS: We evaluated 220 CPETs in 93 patients with LQTS. The mean age at first CPET was 12 +/- 3.9 years. In multivariable analysis, %PHR decreased by 13% for every 1 mg/kg/d increase in beta-blocker dose, demonstrating physiologic beta-blocker effects. However, we identified no correlation between nadolol dose and measures of cardiopulmonary fitness. Neither peak Vo(2) nor peak RER was correlated with nadolol dose. Only mild blood pressure changes were observed (<9 mm Hg decrease at peak exertion per 1 mg/kg increase in nadolol dose). Increased atenolol dose was also associated with stable peak Vo(2) and peak RER. CONCLUSIONS: In children with LQTS, we did not observe any relationship between higher nadolol doses and objective measures of effort (peak RER) or cardiopulmonary fitness (peak Vo(2)), despite a linear dose-response between nadolol dose and %PHR. These results suggest that treatment with nadolol for LQTS does not affect most patients' peak exercise performance. These data were validated in patients from an earlier era who had been prescribed atenolol. CI - Copyright (c) 2026 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. FAU - Webster, Gregory AU - Webster G AD - Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Electronic address: rgwebster@luriechildrens.org. FAU - Gill, Nathan AU - Gill N AD - Division of Biostatistics and Informatics, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Carberry, Thomas AU - Carberry T AD - Corewell Health Helen Devos Children's Hospital, Michigan State University College of Human Medicine, Grand Rapids, Michigan, USA. FAU - Chandler, Stephanie F AU - Chandler SF AD - Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Cherny, Sara AU - Cherny S AD - Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Lockhart, Elli N AU - Lockhart EN AD - Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Onorato, Angela C AU - Onorato AC AD - The Heart Center, Nationwide Children's Hospital, Columbus, Ohio, USA. FAU - Dillenbeck, Halley AU - Dillenbeck H AD - Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Ward, Kendra AU - Ward K AD - Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Laternser, Christina AU - Laternser C AD - Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. LA - eng GR - R01 HL164773/HL/NHLBI NIH HHS/United States GR - UL1 TR001422/TR/NCATS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260709 PL - United States TA - JACC Clin Electrophysiol JT - JACC. Clinical electrophysiology JID - 101656995 RN - 0 (Adrenergic beta-Antagonists) RN - 50VV3VW0TI (Atenolol) RN - 42200-33-9 (Nadolol) SB - IM MH - Humans MH - Child MH - *Long QT Syndrome/drug therapy/physiopathology MH - Exercise Test MH - *Adrenergic beta-Antagonists/therapeutic use/pharmacology MH - Female MH - Retrospective Studies MH - Adolescent MH - Male MH - Atenolol/therapeutic use MH - Heart Rate/drug effects MH - Oxygen Consumption/drug effects MH - Nadolol/therapeutic use/pharmacology MH - Blood Pressure/drug effects MH - *Exercise/physiology MH - Cardiorespiratory Fitness/physiology PMC - PMC13502152 MID - NIHMS2192871 OTO - NOTNLM OT - beta-adrenergic receptor antagonist OT - cardiopulmonary exercise test OT - electrophysiology OT - long QT syndrome OT - pediatric OT - pharmacology COIS- Funding Support and Author Disclosures The Northwestern University Clinical and Translational Sciences Institute is funded in part by a Clinical and Translational Science Award grant from the National Institutes of Health (UL1TR001422). This study was supported, in part, by the National Institutes of Health/National Heart, Lung, and Blood Institute (R01 HL164773) and philanthropic donors. Dr Webster has served as a consultant for Solid Biosciences. Dr Ward has served as a site principal investigator for a trial funded by Mezzion Pharmaceuticals. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. EDAT- 2026/07/10 12:46 MHDA- 2026/08/25 11:38 PMCR- 2026/08/25 CRDT- 2026/07/10 10:27 PHST- 2026/03/18 00:00 [received] PHST- 2026/05/22 00:00 [revised] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/08/25 11:38 [medline] PHST- 2026/07/10 12:46 [pubmed] PHST- 2026/07/10 10:27 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - S2405-500X(26)00558-X [pii] AID - 10.1016/j.jacep.2026.06.010 [doi] PST - ppublish SO - JACC Clin Electrophysiol. 2026 Aug;12(8):2010-2018. doi: 10.1016/j.jacep.2026.06.010. Epub 2026 Jul 9. PMID- 42429700 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260821 IS - 1879-1972 (Electronic) IS - 1054-139X (Print) IS - 1054-139X (Linking) VI - 79 IP - 3 DP - 2026 Sep TI - Cultural Food Practices and Their Potential Role in Mitigating Disordered Eating Among American Indian/First Nations Youth. PG - 404-411 LID - S1054-139X(26)00191-6 [pii] LID - 10.1016/j.jadohealth.2026.05.006 [doi] AB - PURPOSE: Explore the relationship between disordered eating and engagement in cultural food practices in a sample of American Indian/First Nations (AI/FNs) adolescents. METHODS: Using interviewer-administered surveys data derived from Healing Pathways (N = 661), a longitudinal community-based participatory research study with Midwest AI/FN communities, we examined disordered eating, cultural food practices, and related sociodemographic variables in AI/FN adolescents using data from two time points/waves of this larger longitudinal study. We examined the structure of a disordered eating questionnaire using exploratory factor analysis to reveal psychometric properties of the questionnaire, resulting in three distinct disordered eating constructs "binge eating," "obsessive food behaviors," and "altered feelings about body." Associations with cultural food practices and these disordered eating constructs were examined using adjusted and unadjusted linear regression models. RESULTS: Greater engagement in cultural food practices was significantly associated with lower levels of "altered feelings about body" in both unadjusted (beta = -0.27, standard error [SE] = 0.04, p < .001) and adjusted models (beta = -0.11, SE = 0.05, p < .05). Identifying as female was linked to higher levels of both "obsessive food behaviors" (adjusted beta = 0.36, SE = 0.12, p < .05) and "altered feelings about body" (adjusted beta = 1.65, SE = 0.16, p < .001). DISCUSSION: Participation in cultural food practices may potentially play an important role in creating and sustaining healthy eating behaviors for AI/FN youth. Future research should consider the impact of disordered eating on nutrition-related health behaviors, as well as the potential protective role of cultural food practices against unhealthy eating behaviors. CI - Copyright (c) 2026 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved. FAU - Maudrie, Tara L AU - Maudrie TL AD - University of Michigan, School of Social Work, Ann Arbor, Michigan; Department of Health Behavior & Health Equity, University of Michigan, School of Public Health, Ann Arbor, Michigan. FAU - Gillson, Stefanie AU - Gillson S AD - Yale School of Medicine, Child Study Center, New Haven, Connecticut. FAU - Anderson, Olivia AU - Anderson O AD - Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. FAU - Walls, Melissa L AU - Walls ML AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Center for Indigenous Health, Great Lakes Hub, Duluth, Minnesota. FAU - Steinberg, Rachel AU - Steinberg R AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Center for Indigenous Health, Great Lakes Hub, Duluth, Minnesota. FAU - Williams, Stephanie AU - Williams S AD - Healing Pathways, Community Research Council, Duluth, Minnesota. FAU - Hautala, Dane AU - Hautala D AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Center for Indigenous Health, Great Lakes Hub, Duluth, Minnesota. LA - eng GR - R01 DA039912/DA/NIDA NIH HHS/United States GR - U54 CA280805/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20260710 PL - United States TA - J Adolesc Health JT - The Journal of adolescent health : official publication of the Society for Adolescent Medicine JID - 9102136 SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - Community-Based Participatory Research MH - *Feeding and Eating Disorders/ethnology/prevention & control/psychology MH - *Feeding Behavior/ethnology/psychology MH - *Indians, North American/psychology MH - Longitudinal Studies MH - Surveys and Questionnaires MH - *Indigenous Canadians/psychology PMC - PMC13488913 MID - NIHMS2201366 OTO - NOTNLM OT - AI/AN OT - Disordered eating OT - Food sovereignty OT - Indigenous OT - Nutrition OT - Traditional foods COIS- Conflicts of interest: The authors report no conflicts of interest. EDAT- 2026/07/10 12:45 MHDA- 2026/08/04 00:35 PMCR- 2026/08/19 CRDT- 2026/07/10 10:27 PHST- 2025/12/15 00:00 [received] PHST- 2026/04/30 00:00 [revised] PHST- 2026/05/04 00:00 [accepted] PHST- 2026/08/04 00:35 [medline] PHST- 2026/07/10 12:45 [pubmed] PHST- 2026/07/10 10:27 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - S1054-139X(26)00191-6 [pii] AID - 10.1016/j.jadohealth.2026.05.006 [doi] PST - ppublish SO - J Adolesc Health. 2026 Sep;79(3):404-411. doi: 10.1016/j.jadohealth.2026.05.006. Epub 2026 Jul 10. PMID- 42427950 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260710 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - The association between social media use and dietary intake among adolescents in Turkiye: a cross sectional study. PG - 1862690 LID - 10.3389/fped.2026.1862690 [doi] LID - 1862690 AB - INTRODUCTION: Social media usage has surged up among adolescents and its relationship with dietary intake is unclear. This paper investigated the association between social media use and dietary intake among adolescents in Turkiye. METHODS: A cross sectional study was conducted. Convenience sampling was chosen. Private schools located in two cities in the Central and Eastern regions of Turkiye (Sanliurfa and Karaman). The sample consisted of 251 adolescents (13-18 years of age) and 49% of them were male. Dietary data were collected using a validated food frequency questionnaire. The multiple regression analysis adjusted for age groups were used to assess the relationship between social media use and dietary intake. Then Benjamini-Hochberg FDR correction was applied. All the data are based on beta (unstandardized) with standard error (SE) (beta+/-SE). RESULTS: Fewer than half of the participants reported using social media for over three hours daily (47.4%). The late adolescents used social media more than three hours a day (p < 0.05). Prolonged social media use (>3 h) was associated with higher energy (beta = 356.21 +/- 111.91 kcal, p = 0.002), carbohydrate (beta = 41.19 +/- 14.82 g, p = 0.006), sucrose (beta = 10.75 +/- 3.24 g, p = 0.001), fat (beta = 16.51 +/- 5.83 g, p = 0.005), calcium (beta= 146.44 +/- 54.72 mg, p = 0.008) and zinc (beta = 2.16 +/- 0.75 mg, p = 0.004) intake. Participants who were on social media for more than three hours a day consumed an average of 87.91 g more milk and yoghurt, 27.92 g more meat and processed meat, and 34.38 g more pastry than those who were on social media less than three hours a day. However after Benjamini-Hochberg False Discovery Rate correction, no relationship was found between dairy, meat and pastry consumption with social media duration (p > 0.05). Spending more time on social media was also related to more added sugar consumption (beta = 9.23 +/- 3.38 g, p = 0.007). CONCLUSIONS: The results indicate that prolonged use of social media is associated with higher energy, fat, sucrose, zinc and calcium consumption. These adolescents have a diet richer in micronutrients but also they follow a more obesogenic dietary pattern, which may be related to an increased risk of inflammatory and chronic diseases later in life. Longitudinal studies are needed to determine a causal relationship. CI - (c) 2026 Ozturk. FAU - Ozturk, Meryem Elif AU - Ozturk ME AD - Department of Nutrition and Dietetics, Karamanoglu Mehmetbey University, Karaman, Turkiye. LA - eng PT - Journal Article DEP - 20260625 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13345838 OTO - NOTNLM OT - adolescents OT - dietary intake OT - energy intake OT - social media OT - sucrose COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/10 06:34 MHDA- 2026/07/10 06:35 PMCR- 2026/06/25 CRDT- 2026/07/10 05:11 PHST- 2026/04/22 00:00 [received] PHST- 2026/06/03 00:00 [revised] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/07/10 06:35 [medline] PHST- 2026/07/10 06:34 [pubmed] PHST- 2026/07/10 05:11 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.3389/fped.2026.1862690 [doi] PST - epublish SO - Front Pediatr. 2026 Jun 25;14:1862690. doi: 10.3389/fped.2026.1862690. eCollection 2026. PMID- 42426319 OWN - NLM STAT- Publisher LR - 20260709 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) DP - 2026 Jul 9 TI - Explainable machine learning integrating environmental chemical biomarkers and maternal clinical factors for prediction of hypertensive disorder of pregnancy. LID - 10.1038/s41598-026-61841-8 [doi] AB - Hypertensive disorders of pregnancy (HDP) represent a leading cause of maternal morbidity, yet environmental chemical contributors to HDP risk remain poorly characterized within predictive frameworks. We developed and evaluated an explainable machine-learning model integrating environmental biomarkers with maternal clinical characteristics for HDP prediction using data from 4,260 pregnant women enrolled in the Korean Children's Environmental Health Study (Ko-CHENS) prospective birth cohort. An Extreme Gradient Boosting (XGBoost) classifier incorporating 18 environmental biomarkers-including blood lead, cadmium, mercury, and endocrine-disrupting chemicals-alongside maternal clinical covariates was trained using stratified 60/20/20 data splits with Bayesian hyperparameter optimization. The optimized model achieved a cross-validated ROC-AUC of 0.787 and an independent test ROC-AUC of 0.748 (95% CI: 0.587-0.887), with a negative predictive value of 0.994 under severe class imbalance (HDP prevalence: 1.7%). SHapley Additive exPlanations (SHAP) analysis identified late-pregnancy blood lead concentration and pre-pregnancy body mass index as the dominant predictors, each exhibiting non-linear risk gradients; formal SHAP interaction values (1.6% of combined attribution) and an independent logistic-regression interaction term (beta = 0.418, 95% CI - 0.278-1.115, p = 0.239) indicated additive rather than synergistic BMI-lead pathways. These findings demonstrate that environmental biomarkers contribute independent, non-linear predictive value beyond established clinical risk factors, supporting integration of environmental exposure surveillance into precision obstetric risk stratification. CI - (c) 2026. The Author(s). FAU - Wang, Changwon AU - Wang C AD - Department of Integrated Healthcare Science, Soonchunhyang University, Asan, 31538, Republic of Korea. FAU - Lee, Jong-Dae AU - Lee JD AD - Department of Environmental Health Science, Soonchunhyang University, Asan, 31538, Republic of Korea. FAU - Kim, Ju Hee AU - Kim JH AD - Department of Nursing, College of Nursing Science, Kyung Hee University, Seoul, 02447, Republic of Korea. juheekim@khu.ac.kr. LA - eng GR - No. 5199990914048/BK21 FOUR (Fostering Outstanding Universities for Research/ PT - Journal Article DEP - 20260709 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM OTO - NOTNLM OT - Environmental chemical exposure OT - Explainable artificial intelligence OT - Hypertensive disorder of pregnancy OT - Machine learning COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/07/10 00:36 MHDA- 2026/07/10 00:36 CRDT- 2026/07/09 23:35 PHST- 2026/04/04 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/07/10 00:36 [medline] PHST- 2026/07/10 00:36 [pubmed] PHST- 2026/07/09 23:35 [entrez] AID - 10.1038/s41598-026-61841-8 [pii] AID - 10.1038/s41598-026-61841-8 [doi] PST - aheadofprint SO - Sci Rep. 2026 Jul 9. doi: 10.1038/s41598-026-61841-8. PMID- 42426095 OWN - NLM STAT- Publisher LR - 20260709 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) DP - 2026 Jul 9 TI - Integrated framework for pediatric height assessment: X-ray-based height extreme cases classification and machine learning for multivariate height prediction. LID - 10.1038/s41598-026-56423-7 [doi] AB - Pediatric height assessment is crucial for evaluating growth and enabling timely intervention. However, traditional methods primarily assess current bone age rather than identifying future height abnormalities. This study proposes an integrated framework with two components: one uses hand X-ray images and clinical features to predict potential extreme height cases after one year; the other employs multivariate data to predict height across different time scales. To predict potential extreme cases, we employed fine-tuned Inception-ResNet-V2 as our classification model, while addressing class data imbalance through the DSEV method. For multivariate height prediction, we used XGBoost as our prediction model, incorporating various anthropometric and medical features, such as sex, age, body height, birth weight, medical diagnosis, and treatment. Results demonstrate that our classification models achieved outstanding performance in detecting unexpectedly short and unexpectedly tall cases, showing exceptional accuracy and reliability. Our multivariate prediction models demonstrated very low mean absolute error for predictions within 6 months, 1 year, 2 years, and near-final adult height, with consistent and stable performance. This integrated framework provides clinicians with more precise and comprehensive tools for evaluating children's growth and planning interventions. CI - (c) 2026. The Author(s). FAU - Chang, Ya-Wen AU - Chang YW AD - Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, 701, Taiwan ROC. FAU - Tsai, Meng-Che AU - Tsai MC AD - Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, Tainan, Taiwan ROC. mengchets@gs.ncku.edu.tw. FAU - Hsieh, Sun-Yuan AU - Hsieh SY AD - Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, 701, Taiwan ROC. hsiehsy@mail.ncku.edu.tw. AD - The Institute of Information Science, Academia Sinica, Taipei, 115201, Taiwan ROC. hsiehsy@mail.ncku.edu.tw. AD - The Research Center for Information Technology Innovation, Academia Sinica, Taipei, 115201, Taiwan ROC. hsiehsy@mail.ncku.edu.tw. AD - The Institute of Medical Informatics, National Cheng Kung University, Tainan, 701, Taiwan ROC. hsiehsy@mail.ncku.edu.tw. AD - Institute of Manufacturing Information and Systems, National Cheng Kung University, Tainan, 701, Taiwan ROC. hsiehsy@mail.ncku.edu.tw. LA - eng PT - Journal Article DEP - 20260709 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM OTO - NOTNLM OT - Artificial Intelligence OT - Bone Age OT - Deep Learning OT - Growth Abnormalities OT - Hand X-ray OT - Height Prediction OT - Machine Learning COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/07/10 00:35 MHDA- 2026/07/10 00:35 CRDT- 2026/07/09 23:26 PHST- 2025/11/22 00:00 [received] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/07/10 00:35 [medline] PHST- 2026/07/10 00:35 [pubmed] PHST- 2026/07/09 23:26 [entrez] AID - 10.1038/s41598-026-56423-7 [pii] AID - 10.1038/s41598-026-56423-7 [doi] PST - aheadofprint SO - Sci Rep. 2026 Jul 9. doi: 10.1038/s41598-026-56423-7. PMID- 42425048 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260904 IS - 1879-0046 (Electronic) IS - 0376-8716 (Linking) VI - 286 DP - 2026 Sep 1 TI - Youth's perception of parental limitation of youth screen time is associated with lower odds of nicotine vaping among US youth: Results from the 2024 National Survey on Drug Use and Health (NSDUH). PG - 113260 LID - S0376-8716(26)00241-3 [pii] LID - 10.1016/j.drugalcdep.2026.113260 [doi] AB - BACKGROUND: Youth media exposure is associated with vaping, while parental limitation of youth screen time may be associated with lower odds of youth vaping. Using nationally representative survey data, this study examines these relationships. METHODS: We used youth (aged 12-17) data from the 2024 National Survey on Drug Use and Health (N = 11,334) and defined past-month nicotine vaping as a binary variable (yes/no). Past-year youth's perception of parental limitation of youth screen time (television, tablets, smartphones, computers, and video games) was categorized as never, seldom, sometimes, or always. To estimate associations between youth's perception of parental limitation of screen time and past-month nicotine vaping, we conducted binomial logistic regression, controlling for relevant covariates. RESULTS: Overall, 5.5% of adolescents reported past-month nicotine vaping; 29.9% reported that parents never limited screen time, compared with 16.6% who reported always limiting screen time. In adjusted models, higher levels of youth's perception of screen time limitation were associated with lower odds of past-month nicotine vaping (AOR = 0.78, 95% CI = 0.66, 0.92). Several sensitivity analyses validated the findings. CONCLUSIONS: These findings identify that youth's perception of parental limitation of screen time was associated with lower odds of nicotine vaping among youth. Future studies should assess direct parental reports of restriction of youth screen time and examine comprehensive media-use approaches that combine screen-time limits in addition to general parenting practices. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Lee, Juhan AU - Lee J AD - Department of Epidemiology and Population Health, Albert Einstein College of Medicine, United States; Department of Epidemiology and Population Health, Montefiore Einstein Comprehensive Cancer Center, United States. Electronic address: juhan.lee@einsteinmed.edu. FAU - Mattingly, Delvon T AU - Mattingly DT AD - Department of Behavioral Science, University of Kentucky College of Medicine, United States; Center for Health, Engagement, and Transformation, University of Kentucky College of Medicine, United States. LA - eng PT - Journal Article DEP - 20260704 PL - Ireland TA - Drug Alcohol Depend JT - Drug and alcohol dependence JID - 7513587 SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - Child MH - *Vaping/epidemiology/psychology MH - United States/epidemiology MH - *Screen Time MH - *Parents MH - Health Surveys MH - Media Exposure MH - *Perception OTO - NOTNLM OT - Media exposure OT - Nicotine vaping OT - Screen time OT - Youth COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/10 04:10 MHDA- 2026/09/04 23:36 CRDT- 2026/07/09 18:11 PHST- 2026/03/15 00:00 [received] PHST- 2026/06/06 00:00 [revised] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/09/04 23:36 [medline] PHST- 2026/07/10 04:10 [pubmed] PHST- 2026/07/09 18:11 [entrez] AID - S0376-8716(26)00241-3 [pii] AID - 10.1016/j.drugalcdep.2026.113260 [doi] PST - ppublish SO - Drug Alcohol Depend. 2026 Sep 1;286:113260. doi: 10.1016/j.drugalcdep.2026.113260. Epub 2026 Jul 4. PMID- 42424543 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1751-7893 (Electronic) IS - 1751-7885 (Print) IS - 1751-7885 (Linking) VI - 20 IP - 7 DP - 2026 Jul TI - A Randomised Feasibility Trial of a Service-Coordinated Exercise Intervention in First-Episode Psychosis: Challenges in Implementation and Outcome Assessment. PG - e70193 LID - 10.1111/eip.70193 [doi] LID - e70193 AB - BACKGROUND: Psychosis is increasingly recognised as a systemic disorder characterised by interrelated metabolic dysfunction, chronic low-grade inflammation and sedentary lifestyles. Physical exercise is a promising intervention to address this triad. This pilot study investigated the feasibility and systemic impact of a pragmatic exercise intervention within a first-episode psychosis (FEP) service. METHODS: We conducted a parallel-group randomised controlled trial involving people with FEP, comparing an 8-week structured aerobic and resistance training programme to Treatment As Usual. We assessed feasibility of the intervention and assessments by measuring recruitment, attendance, retention, and engagement with assessments. Exploratory outcome measures spanned physical fitness, metabolic health, psychometric scales and the Cambridge Neuropsychological Test Automated Battery (CANTAB) cognitive battery. RESULTS: The study recruited 40 participants, 19 in the intervention and 21 in the control group. At baseline assessment, 23 of 38 had an elevated BMI and 24 of 35 had elevated cholesterol. Study retention was adequate, with only four participants (10%) lost to follow up. However, the assessment battery was poorly completed, highlighting its infeasibility. Fitness outcomes proved especially challenging, with between 11 and 13 participants (27.5% to 32.5%) completing both baseline and endpoint assessments. Of the 19 people recruited to the intervention arm, 7 (36.8%) attended less than half of the 8 sessions. Outcome data were limited by substantial missingness, with no consistent pattern of benefit or harm observed across domains. CONCLUSIONS: Implementing exercise within real-world FEP services is challenging as indicated by the attrition observed in our study. Future research should individualise exercise prescription and minimise participant assessment burden to mitigate attrition. CI - (c) 2026 The Author(s). Early Intervention in Psychiatry published by John Wiley & Sons Australia, Ltd. FAU - O'Mahony, Brian W AU - O'Mahony BW AUID- ORCID: 0000-0002-1530-0167 AD - UCD Centre for Psychosis Research, School of Medicine, University College Dublin, Dublin, Ireland. FAU - Wycherley, Elizabeth AU - Wycherley E AD - RISE, Blackrock Hall Primary Care Centre, Cork, Ireland. FAU - Daly, Karen AU - Daly K AD - RISE, Blackrock Hall Primary Care Centre, Cork, Ireland. FAU - Cowman, Meghan AU - Cowman M AD - RISE, Blackrock Hall Primary Care Centre, Cork, Ireland. FAU - Lonergan, Edgar AU - Lonergan E AD - RISE, Blackrock Hall Primary Care Centre, Cork, Ireland. FAU - Owens, Abigale AU - Owens A AD - RISE, Blackrock Hall Primary Care Centre, Cork, Ireland. FAU - O'Mahony, Karen AU - O'Mahony K AD - RISE, Blackrock Hall Primary Care Centre, Cork, Ireland. FAU - O'Donoghue, Brian AU - O'Donoghue B AUID- ORCID: 0000-0001-6240-6952 AD - UCD Centre for Psychosis Research, School of Medicine, University College Dublin, Dublin, Ireland. AD - Department of Psychiatry, St Vincent's University Hospital, Dublin, Ireland. FAU - Clarke, Gerard AU - Clarke G AUID- ORCID: 0000-0001-9771-3979 AD - Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland. AD - APC Microbiome Ireland, Biosciences Research Institute, University College Cork, Cork, Ireland. FAU - O'Connor, Karen AU - O'Connor K AUID- ORCID: 0000-0003-0696-8576 AD - RISE, Blackrock Hall Primary Care Centre, Cork, Ireland. AD - Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland. LA - eng GR - ICAT-2022-001/HRBI_/Health Research Board/Ireland PT - Journal Article PT - Pragmatic Clinical Trial PT - Randomized Controlled Trial PL - Australia TA - Early Interv Psychiatry JT - Early intervention in psychiatry JID - 101320027 SB - IM MH - Humans MH - *Psychotic Disorders/therapy/psychology MH - Female MH - Feasibility Studies MH - Male MH - Adult MH - Pilot Projects MH - *Exercise Therapy/methods MH - Young Adult MH - *Outcome Assessment, Health Care MH - *Exercise MH - Adolescent PMC - PMC13349341 OTO - NOTNLM OT - attrition OT - exercise OT - feasibility OT - first-episode psychosis OT - metabolic health OT - physical health COIS- G.C. received honoraria from Janssen, Heel Pharmaceuticals, Probi, Boehringer Ingelheim and Apsen as an invited speaker; and research funding from Pharmavite, Reckitt, Tate and Lyle, Nestle and Fonterra. G.C. is or has been a paid consultant for Heel Pharmaceuticals, Bayer Healthcare, Yakult and Zentiva. All other authors declare no competing interests. EDAT- 2026/07/09 22:36 MHDA- 2026/07/10 12:45 PMCR- 2026/07/09 CRDT- 2026/07/09 15:23 PHST- 2026/06/05 00:00 [revised] PHST- 2026/05/01 00:00 [received] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/07/10 12:45 [medline] PHST- 2026/07/09 22:36 [pubmed] PHST- 2026/07/09 15:23 [entrez] PHST- 2026/07/09 00:00 [pmc-release] AID - EIP70193 [pii] AID - 10.1111/eip.70193 [doi] PST - ppublish SO - Early Interv Psychiatry. 2026 Jul;20(7):e70193. doi: 10.1111/eip.70193. PMID- 42423536 OWN - NLM STAT- MEDLINE DCOM- 20260928 LR - 20260929 IS - 2198-3844 (Electronic) IS - 2198-3844 (Linking) VI - 13 IP - 54 DP - 2026 Sep TI - Frequent Sweetened Beverage Consumption Is Associated With Accelerated Biological Aging: Evidence From a Population-Based Study and Gut Microbiota Analysis. PG - e76460 LID - 10.1002/advs.76460 [doi] LID - e76460 AB - Although substantial evidence links sweetened beverage (SB) intake to chronic diseases, its association with biological aging and underlying mechanisms remains unclear. This population-based study included 9104 adults aged 18-80 years from the WELL-China cohort. SB consumption was assessed using a validated food frequency questionnaire. Biological age and biological age acceleration (BAacc) were estimated using the Klemera and Doubal method (KDM). After multivariable adjustment, frequent SB consumption was significantly associated with accelerated KDM-derived BAacc, compared with non-consumers (beta = 0.29 years, 95% CI: 0.06-0.52). This association was stronger among participants younger than 55 years (P for interaction < 0.05). Gut microbiota was profiled using 16S rRNA gene sequencing. We identified 10 genera significantly associated with the frequent SB consumption, and 56 genera significantly associated with BAacc. Notably, five genera (Allisonella, Lactobacillus, Weissella, Lactococcus, and Bacilli_unclassified) were shared between the two analyses and enriched in both frequent SB consumers and individuals with higher BAacc. Frequent SB consumption is associated with accelerated biological aging, especially among adults younger than 55 years. Shared gut microbial signatures associated with both SB intake and BAacc suggest a potential microbiota-related pathway. These findings support reducing SB consumption as a potential strategy for promoting healthy aging. CI - (c) 2026 The Author(s). Advanced Science published by Wiley-VCH GmbH. FAU - Shi, Yuwei AU - Shi Y AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Li, Xinmei AU - Li X AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Hao, Yufan AU - Hao Y AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Wu, Qiaoyu AU - Wu Q AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Yu, Yuji AU - Yu Y AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Li, Siyu AU - Li S AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Xu, Nuo AU - Xu N AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Wu, Yi-Hsuan AU - Wu YH AD - Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, California, USA. FAU - Lee, Eunhye AU - Lee E AD - Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, California, USA. FAU - Chang, Chi AU - Chang C AD - Office of Medical Education Research and Development, College of Medicine, Michigan State University, East Lansing, Michigan, USA. FAU - Hu, Emily AU - Hu E AD - Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, California, USA. FAU - Lu, Ying AU - Lu Y AUID- ORCID: 0000-0002-7698-8962 AD - Department of Biomedical Data Science, Stanford School of Medicine, Stanford University, Stanford, California, USA. FAU - Delzell, Elizabeth AU - Delzell E AD - Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, California, USA. FAU - Hsing, Ann W AU - Hsing AW AD - Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, California, USA. AD - Department of Epidemiology and Population Health, Stanford School of Medicine, Stanford University, Stanford, California, USA. AD - Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, California, USA. FAU - Zhu, Shankuan AU - Zhu S AUID- ORCID: 0000-0002-9509-7364 AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. LA - eng GR - China Medical Board (CMB)/ GR - 419600-11102/Cyrus Tang Foundation/ GR - 419600-11107/Chou Fund of Zhejiang University Education Foundation/ PT - Journal Article DEP - 20260709 PL - Germany TA - Adv Sci (Weinh) JT - Advanced science (Weinheim, Baden-Wurttemberg, Germany) JID - 101664569 RN - 0 (RNA, Ribosomal, 16S) SB - IM MH - Humans MH - *Gastrointestinal Microbiome/genetics/physiology MH - *Aging/physiology MH - Middle Aged MH - Adult MH - Aged MH - Female MH - Male MH - RNA, Ribosomal, 16S/genetics MH - China MH - Aged, 80 and over MH - Young Adult MH - *Sugar-Sweetened Beverages/adverse effects MH - Adolescent MH - Cohort Studies MH - *Beverages/adverse effects PMC - PMC13348652 OTO - NOTNLM OT - aging OT - biological age acceleration OT - gut microbiota OT - sweetened beverage COIS- The authors declare no conflicts of interest. EDAT- 2026/07/09 12:33 MHDA- 2026/09/28 11:38 PMCR- 2026/07/09 CRDT- 2026/07/09 10:23 PHST- 2026/06/13 00:00 [revised] PHST- 2026/01/20 00:00 [received] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/09/28 11:38 [medline] PHST- 2026/07/09 12:33 [pubmed] PHST- 2026/07/09 10:23 [entrez] PHST- 2026/07/09 00:00 [pmc-release] AID - ADVS76460 [pii] AID - 10.1002/advs.76460 [doi] PST - ppublish SO - Adv Sci (Weinh). 2026 Sep;13(54):e76460. doi: 10.1002/advs.76460. Epub 2026 Jul 9. PMID- 42423249 OWN - NLM STAT- Publisher LR - 20260715 IS - 1469-7610 (Electronic) IS - 0021-9630 (Linking) DP - 2026 Jul 9 TI - The association between 24-hr movement patterns and self-harm incidence in adolescence. LID - 10.1111/jcpp.70199 [doi] AB - BACKGROUND: Self-harm is a pressing public health issue, particularly among adolescents. Physical activity is associated with reduced self-harm among youths, but evidence is limited. Most studies rely on self-reported measures and are primarily focused on moderate-to-vigorous physical activity (MVPA), often overlooking the role of light-intensity physical activity (LIPA). To address these gaps, we investigated the prospective associations between accelerometer-measured 24-hr movements and subsequent self-harm in adolescents. METHODS: This prospective cohort investigation analysed 2,016 children from the UK Millennium Cohort Study using data from the age 7 years survey (MCS4) when accelerometers were introduced (mean age = 7.23 years, SD = 0.25). Accelerometer-measured duration of MVPA, LIPA, sedentary behaviour (SB), and sleep were analysed. Self-harm behaviours were assessed via validated self-report questionnaires at ages 14 and 17 years, and subsequently, the associations examined using logistic and compositional data models. RESULTS: Among 2,016 participants (48.6% female), 548 self-harm cases occurred during 18,696 person-years of follow-up, with a median follow-up duration of 8.5 years (cumulative incidence = 27.2%). LIPA was inversely associated with self-harm (OR 0.76, 95% CI: 0.65-0.88). This association was stronger in compositional models (OR 0.23, 95% CI: 0.11-0.47). MVPA showed a significant non-linear, inverted U-shaped association with self-harm (p for non-linearity = .02). The risk peaked at approximately 1.2 hr/day and decreased substantially at levels exceeding 1.7 hr/day, while SB and sleep were not significantly associated with self-harm. Stratified analyses confirmed robustness. CONCLUSIONS: Our findings reveal a pronounced inverse association between LIPA and self-harm, along with a non-linear association for MVPA. These results support 24-hr movement guidelines that emphasise activity transitions over isolated targets and highlight LIPA's role in early prevention strategies. CI - (c) 2026 The Author(s). Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health. FAU - Huang, Siyi AU - Huang S AUID- ORCID: 0000-0002-9461-2029 AD - Department of Infectious Diseases and Public Health, City University of Hong Kong, Hong Kong, China. AD - Department of Sports Science, College of Education, Zhejiang University, Hangzhou, China. FAU - Cui, Jiameng AU - Cui J AD - Department of Big Data in Health Science, School of Public Health, Zhejiang University School of Medicine, Hangzhou, China. FAU - He, Qida AU - He Q AD - Department of Infectious Diseases and Public Health, City University of Hong Kong, Hong Kong, China. FAU - Ali, Shahmir H AU - Ali SH AD - Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore. FAU - Wang, Qi AU - Wang Q AD - Department of Data Science, City University of Hong Kong, Hong Kong, China. FAU - Thomas, G Neil AU - Thomas GN AD - Department of Applied Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK. FAU - Li, Linyan AU - Li L AD - Department of Infectious Diseases and Public Health, City University of Hong Kong, Hong Kong, China. AD - Department of Data Science, City University of Hong Kong, Hong Kong, China. LA - eng GR - CityU21607223/Research Grants Council, University Grants Committee, Hong Kong/ GR - 7020097;7030008/City University of Hong Kong/ GR - City University of Hong Kong Institute of Digital Medicine/ PT - Journal Article DEP - 20260709 PL - England TA - J Child Psychol Psychiatry JT - Journal of child psychology and psychiatry, and allied disciplines JID - 0375361 SB - IM OTO - NOTNLM OT - Millennium Cohort Study OT - Non-suicidal self-harm OT - compositional data analysis OT - light-intensity physical activity OT - youth mental health EDAT- 2026/07/09 13:24 MHDA- 2026/07/09 13:24 CRDT- 2026/07/09 07:52 PHST- 2026/06/03 00:00 [accepted] PHST- 2026/07/09 13:24 [pubmed] PHST- 2026/07/09 13:24 [medline] PHST- 2026/07/09 07:52 [entrez] AID - 10.1111/jcpp.70199 [doi] PST - aheadofprint SO - J Child Psychol Psychiatry. 2026 Jul 9. doi: 10.1111/jcpp.70199. PMID- 42422709 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Prevalence and factors associated with adolescent idiopathic scoliosis in Shanghai, China: an artificial intelligence-assisted screening approach. PG - 1832421 LID - 10.3389/fpubh.2026.1832421 [doi] LID - 1832421 AB - OBJECTIVE: To investigate the prevalence of adolescent idiopathic scoliosis (AIS) and major modifiable factors associated with AIS among school students in Shanghai, China, and assess the feasibility and validated accuracy of AI-assisted 3D screening in school health management. METHODS: A multistage stratified cluster sampling design was employed in this cross-sectional study, conducted from July 2024 to June 2025. A structured-light 3D back-scanning AI system was used to screen 5,026 students aged 9-15 years from six schools in five districts of Shanghai. Physical fitness tests and questionnaires were used to collect data on body morphology, posture, physical activity, and lifestyle. Standing full-spine radiography was used as the reference standard for AIS diagnosis, defined as Cobb angle >/=10 degrees . Because radiographic verification was performed for all screen-positive students but only for a random subset of screen-negative students, inverse probability weighting was applied to account for partial verification. RESULTS: Among the 5,026 screened students, 160 AIS cases were confirmed among 185 rescreen-positive students, and 2 additional AIS cases were identified among 300 randomly verified screen-negative students. The crude radiographically confirmed detection rate was 3.2% (162/5,026), and the IPW-adjusted estimated population prevalence was 3.8%. Thoracic curves and Cobb angles of 10 degrees - < 20 degrees were most common. Girls and middle school students had higher crude radiographic detection rates than boys and primary school students, respectively. Multivariable binary logistic regression identified female sex, improper sitting posture among girls, very low post-exercise fatigue among boys, and frequent one-sided exertion sports as factors associated with screening-detected AIS, whereas higher BMI, balanced walking posture, and satisfactory sleep quality showed protective associations. The AI-assisted structured-light screening workflow showed IPW-adjusted sensitivity of 0.832, specificity of 0.995, PPV of 0.865, NPV of 0.993, and overall accuracy of 0.989. CONCLUSION: AIS represents a non-negligible spinal health burden among school students in Shanghai. Most factors associated with AIS are modifiable. The AI-assisted structured-light screening workflow demonstrated acceptable diagnostic accuracy and promising feasibility for large-scale school-based health screening and management integration. CI - Copyright (c) 2026 Cao, Li, Zhang, Gu, Zheng, Li, Liu, Feng, Yang, Zhang, Xie, Yu, Wu and Xia. FAU - Cao, Yuanyuan AU - Cao Y AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Li, Fangfang AU - Li F AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Zhang, Yong AU - Zhang Y AD - Education Bureau of Baoshan District, Shanghai, China. FAU - Gu, Wenwen AU - Gu W AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Zheng, Xinfeng AU - Zheng X AD - Department of Spine Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China. FAU - Li, Meng AU - Li M AD - Dongciyuan Intelligent Technology Co., Ltd., Shanghai, China. FAU - Liu, Xu AU - Liu X AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Feng, Mengjia AU - Feng M AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Yang, Xilin AU - Yang X AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Zhang, Yulu AU - Zhang Y AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Xie, Shu AU - Xie S AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Yu, Lijuan AU - Yu L AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Wu, Weibing AU - Wu W AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Xia, Jun AU - Xia J AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. LA - eng PT - Journal Article DEP - 20260624 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Scoliosis/epidemiology/diagnosis MH - Female MH - Male MH - China/epidemiology MH - Adolescent MH - Cross-Sectional Studies MH - Prevalence MH - Child MH - *Mass Screening/methods MH - *Artificial Intelligence MH - Risk Factors MH - Surveys and Questionnaires MH - Intelligent Systems PMC - PMC13344153 OTO - NOTNLM OT - 3D camera OT - AI-assisted screening OT - adolescent idiopathic scoliosis OT - machine learning OT - prevalence OT - risk factors COIS- ML was employed by Dongciyuan Intelligent Technology Co., Ltd. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/09 06:32 MHDA- 2026/07/09 06:33 PMCR- 2026/06/24 CRDT- 2026/07/09 04:46 PHST- 2026/03/17 00:00 [received] PHST- 2026/05/11 00:00 [revised] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/07/09 06:33 [medline] PHST- 2026/07/09 06:32 [pubmed] PHST- 2026/07/09 04:46 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1832421 [doi] PST - epublish SO - Front Public Health. 2026 Jun 24;14:1832421. doi: 10.3389/fpubh.2026.1832421. eCollection 2026. PMID- 42422693 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Association between physical activity and mental health among Yi students aged 10-18 years in Southwest China: a school-based cross-sectional study. PG - 1878144 LID - 10.3389/fpubh.2026.1878144 [doi] LID - 1878144 AB - BACKGROUND: Physical activity is a modifiable behavior that may contribute to youth mental health, yet evidence from ethnic minority school populations in Southwest China remains limited. METHODS: This school-based cross-sectional study analyzed questionnaire data from 671 Yi students aged 10-18 years. Physical activity was assessed using an 8-item PAQ-like measure. Mental health was operationalized through three adverse domains: anxiety, loneliness, and social anxiety. Age, sex, and school stage were included as covariates. Psychometric performance was examined using Cronbach's alpha, the Kaiser-Meyer-Olkin statistic, and Bartlett's test of sphericity. Primary associations were estimated with ordinary least squares regression using HC3 robust standard errors, followed by sex- and stage-stratified models, PAQ tertile analyses, linear trend tests, strict complete-item sensitivity analyses, and exploratory parenting extension models. RESULTS: The final sample included 379 girls and 292 boys with a mean age of 13.87 years. Reliability was acceptable to excellent across the four core scales (alpha = 0.709-0.938), and factorability indices supported the use of scores in this sample. Physical activity was inversely correlated with loneliness (r = -0.114, p = 0.003), but not with anxiety or social anxiety. After adjustment, higher physical activity remained associated with lower loneliness (B = -2.13, 95% CI -3.40 to -0.85, p = 0.001), whereas associations with anxiety and social anxiety were not significant. Follow-up analyses showed that the inverse PAQ-loneliness association was more evident among boys and among upper primary and junior secondary students, and the loneliness gradient across PAQ tertiles was statistically significant. In exploratory contextual models, the PAQ coefficient attenuated after father- and mother-related parenting composites were added, while father support and father harsh control showed clear associations with loneliness. CONCLUSION: In this minority school sample, the mental health pattern associated with physical activity was selective rather than global. Higher physical activity was most consistently linked to lower loneliness, while its associations with anxiety and social anxiety were not robust. These findings support a more contextualized public health interpretation of youth physical activity, in which relational connectedness and family climate may shape psychological benefits. CI - Copyright (c) 2026 Shao, Zhang, Li and Wang. FAU - Shao, Qingju AU - Shao Q AD - School of Physical Education, Sichuan Normal University, Chengdu, China. FAU - Zhang, Xiaolin AU - Zhang X AD - School of Physical Education, Sichuan Normal University, Chengdu, China. FAU - Li, Xuefang AU - Li X AD - School of Marxism, Chongqing Normal University, Chongqing, China. FAU - Wang, Jiaheng AU - Wang J AD - School of Physical Education, Sichuan Normal University, Chengdu, China. LA - eng PT - Journal Article DEP - 20260624 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Male MH - Female MH - Cross-Sectional Studies MH - Adolescent MH - China/epidemiology MH - Child MH - *Mental Health/statistics & numerical data/ethnology MH - *Exercise/psychology MH - Loneliness/psychology MH - *Students/psychology/statistics & numerical data MH - Surveys and Questionnaires MH - Anxiety/epidemiology MH - Schools PMC - PMC13342181 OTO - NOTNLM OT - Yi students OT - loneliness OT - mental health OT - physical activity OT - school health OT - social anxiety COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/09 06:33 MHDA- 2026/07/09 06:34 PMCR- 2026/06/24 CRDT- 2026/07/09 04:46 PHST- 2026/05/11 00:00 [received] PHST- 2026/05/24 00:00 [revised] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/07/09 06:34 [medline] PHST- 2026/07/09 06:33 [pubmed] PHST- 2026/07/09 04:46 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1878144 [doi] PST - epublish SO - Front Public Health. 2026 Jun 24;14:1878144. doi: 10.3389/fpubh.2026.1878144. eCollection 2026. PMID- 42422684 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Physical activity, dietary habits, screen time, and sleep duration among Saudi male adolescent athletes and non-athletes: a cross-sectional study. PG - 1871762 LID - 10.3389/fpubh.2026.1871762 [doi] LID - 1871762 AB - BACKGROUND: Adolescence represents a pivotal stage for the development of lifelong health behaviors. In Saudi Arabia, rising obesity and sedentary lifestyles among youth represent growing public health challenges. While organized sports may positively influence lifestyle behaviors, evidence comparing Saudi adolescent athletes and non-athletes across multiple behavioral domains remains limited. PURPOSE: To compare lifestyle habits, including physical activity levels, sedentary behaviors, dietary practices, and sleep duration, between Saudi male adolescent athletes and non-athletes. METHOD: A cross-sectional study of 124 male high school students aged 16-17 years (70 athletes, 54 non-athletes) from Riyadh used a validated 47-item Arab Teen Lifestyle Study (ATLS) questionnaire. Physical activity was measured in METs-minutes per week. Chi-square tests, independent t-tests, and multiple linear regression were applied. RESULT: Athletes exhibited significantly higher physical activity levels (98.6% meeting guidelines compared to 55.6% of non-athletes; p < 0.001) and lower BMI (23.64 +/- 5.39 versus 29.69 +/- 8.34 kg/m(2); p < 0.001). Additionally, a greater proportion of athletes reported consuming fruit on five or more days per week (54.3% versus 33.3%; chi(2) = 8.10, p = 0.017; V = 0.26). Athletes reported shorter average sleep duration (9.06 +/- 3.67 versus 11.28 +/- 3.52 h per day; p = 0.001), although both groups exceeded the minimum recommended 8 h. No significant difference was observed between groups in daily screen time (4.04 +/- 2.63 versus 4.44 +/- 3.08 h; p = 0.44). In an exploratory regression model, frequency of energy drink consumption emerged as the only significant individual predictor of BMI (B = 4.12, 95% CI: 0.32-7.92; p = 0.034), although the overall model was not statistically significant (R (2) = 0.071; F = 1.26; p = 0.278). CONCLUSION: Participation in organized sports is linked to increased physical activity, lower body mass index, and improved fruit consumption among Saudi male adolescents. However, athletes reported reduced sleep duration, and elevated screen time persisted in both groups. These results support the integration of sports programs into adolescent health strategies and highlight the need for comprehensive interventions that address sleep hygiene, screen time management, and the promotion of physical activity. CI - Copyright (c) 2026 Bin Radhyan, Tomar, Bursais and Alaqil. FAU - Bin Radhyan, Fahad AU - Bin Radhyan F AD - Department of Physical Education, College of General Studies, King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia. FAU - Tomar, Rakesh AU - Tomar R AD - Department of Physical Education, College of General Studies, King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia. FAU - Bursais, Abdulmalek K AU - Bursais AK AD - Department of Physical Education, College of Education, King Faisal University, Al-Ahsa, Saudi Arabia. FAU - Alaqil, Abdulrahman I AU - Alaqil AI AD - Department of Physical Education, College of Education, King Faisal University, Al-Ahsa, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260624 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Male MH - Adolescent MH - Saudi Arabia MH - Cross-Sectional Studies MH - Sleep Duration MH - *Exercise MH - *Athletes/statistics & numerical data MH - *Feeding Behavior MH - *Screen Time MH - Surveys and Questionnaires MH - Sedentary Behavior MH - *Diet/statistics & numerical data MH - Life Style MH - Body Mass Index MH - *Sleep PMC - PMC13341710 OTO - NOTNLM OT - Saudi Arabia OT - adolescents OT - body mass index OT - dietary habits OT - physical activity OT - sedentary behavior OT - sleep duration COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/09 06:32 MHDA- 2026/07/09 06:33 PMCR- 2026/06/24 CRDT- 2026/07/09 04:46 PHST- 2026/05/03 00:00 [received] PHST- 2026/05/29 00:00 [revised] PHST- 2026/05/30 00:00 [accepted] PHST- 2026/07/09 06:33 [medline] PHST- 2026/07/09 06:32 [pubmed] PHST- 2026/07/09 04:46 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1871762 [doi] PST - epublish SO - Front Public Health. 2026 Jun 24;14:1871762. doi: 10.3389/fpubh.2026.1871762. eCollection 2026. PMID- 42421701 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260709 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Health-related quality of life in children and adolescents with primary hypertension: a hospital-based cross-sectional study. PG - 1763465 LID - 10.3389/fpsyg.2026.1763465 [doi] LID - 1763465 AB - INTRODUCTION: Primary hypertension in childhood is increasingly recognized as an important health issue, but its impact on health-related quality of life (HRQoL) has not been well studied. METHODS: In this cross-sectional study conducted at the Pediatric Nephrology Department of Ege University Medical Center between June and December 2021, the Pediatric Quality of Life Inventory (PedsQL) 4.0 was administered face-to-face to 22 children and adolescents with primary hypertension and 31 healthy controls, along with their parents. Data were analyzed using IBM SPSS version 26. RESULTS: A total of 53 children and their parents were included. Compared with healthy controls, the primary hypertension group demonstrated significantly lower parent-reported physical health total scores, parent total PedsQL scores, and child physical health total scores. No statistically significant differences were observed between the groups in several other PedsQL subdomains. No significant differences were found in HRQoL scores according to BMI groups or treatment types. CONCLUSION: Children and adolescents with primary hypertension demonstrated lower health-related quality of life scores, particularly in physical health-related domains, compared with healthy controls. These findings suggest that primary hypertension may be associated with impaired quality of life in pediatric patients. Larger, multicenter, longitudinal studies are needed to validate these results. CI - Copyright (c) 2026 Topcak, Bulut Demir, Taner, Tosyali, Keskinoglu, Kabasakal and Kaplan Bulut. FAU - Topcak, Asli Berivan AU - Topcak AB AD - Department of General Pediatrics, Ege University Faculty of Medicine, Izmir, Turkiye. FAU - Bulut Demir, Melek Hande AU - Bulut Demir MH AD - Department of Child and Adolescent Psychiatry, Ministry of Health Dr. Behcet Uz Pediatric Diseases and Surgery Training and Research Hospital, Izmir, Turkiye. FAU - Taner, Sevgin AU - Taner S AD - Department of Pediatric Nephrology, Ege University Faculty of Medicine, Izmir, Turkiye. FAU - Tosyali, Merve AU - Tosyali M AD - Department of General Pediatrics, Ege University Faculty of Medicine, Izmir, Turkiye. FAU - Keskinoglu, Ahmet AU - Keskinoglu A AD - Department of Pediatric Nephrology, Ege University Faculty of Medicine, Izmir, Turkiye. FAU - Kabasakal, Caner AU - Kabasakal C AD - Department of Pediatric Nephrology, Ege University Faculty of Medicine, Izmir, Turkiye. FAU - Kaplan Bulut, Ipek AU - Kaplan Bulut I AD - Department of Pediatric Nephrology, Ege University Faculty of Medicine, Izmir, Turkiye. LA - eng PT - Journal Article DEP - 20260624 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13341690 OTO - NOTNLM OT - PedsQL OT - adolescents OT - children OT - hypertension OT - quality of life COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/09 10:11 MHDA- 2026/07/09 10:12 PMCR- 2026/06/24 CRDT- 2026/07/09 04:34 PHST- 2025/12/08 00:00 [received] PHST- 2026/05/29 00:00 [revised] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/07/09 10:12 [medline] PHST- 2026/07/09 10:11 [pubmed] PHST- 2026/07/09 04:34 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1763465 [doi] PST - epublish SO - Front Psychol. 2026 Jun 24;17:1763465. doi: 10.3389/fpsyg.2026.1763465. eCollection 2026. PMID- 42421336 OWN - NLM STAT- Publisher LR - 20260727 IS - 1475-2662 (Electronic) IS - 0007-1145 (Linking) DP - 2026 Jul 9 TI - Dietary inflammation during pregnancy and later symptoms of offspring behavioural and emotional problems. PG - 1-10 LID - 10.1017/S0007114526107879 [doi] AB - The maternal diet is believed to influence child neurodevelopment, at least in part, through inflammation, as dietary components can have pro- or anti-inflammatory effects. We examined the association between the energy-adjusted dietary inflammatory index (E-DII) during pregnancy and offspring symptoms of behavioural and emotional problems at 5.5 and 10 years, using data from the French nationwide Etude Longitudinale Francaise depuis l'Enfance/French Longitudinal Study since Childhood (ELFE) birth cohort. Dietary intake during pregnancy was assessed using a validated FFQ, and an E-DII score was generated. Child behavioural and emotional symptoms, including hyperactivity-inattention, conduct, peer-relationship and emotional problems, were evaluated by parents using the Strengths and Difficulties Questionnaire at 5.5 (n 9627) and 10 years (n 8362) for hyperactivity-inattention, conduct, peer-relationship and emotional problems. Children were classified into three categories based on thresholds used to identify clinically relevant symptoms: 'Normal', 'Borderline' and 'Atypical'. Multinomial logistic regression adjusted for potential confounders was used to estimate OR and 95 % CI. An increasing maternal E-DII score during pregnancy was associated with higher odds of offspring classified with atypical hyperactivity-inattention and conduct problem scores at 5.5 and 10 years, atypical peer-relationship problem scores at 10 years and atypical emotional problem scores at 10 years (differentially by sex). A more pro-inflammatory diet during pregnancy was consistently associated with higher odds of symptoms of externalising problems throughout childhood and with internalising problems at 10 years. Future research should explore the mechanisms by which prenatal exposure to maternal diet-induced inflammation may contribute to these outcomes. FAU - Dow, Courtney AU - Dow C AUID- ORCID: 0000-0002-9925-8460 AD - Universite Paris Cite and Universite Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics (CRESS), Paris, F-75004, France. ROR: https://ror.org/05f82e368 FAU - Delvert, Rosalie AU - Delvert R AUID- ORCID: 0000-0002-1524-8071 AD - Universite Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Equipe d'Epidemiologie respiratorie integrative, CSEP, Villejuif, France. FAU - de Lauzon-Guillain, Blandine AU - de Lauzon-Guillain B AUID- ORCID: 0000-0001-5887-8842 AD - Universite Paris Cite and Universite Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics (CRESS), Paris, F-75004, France. ROR: https://ror.org/05f82e368 FAU - van der Waerden, Judith AU - van der Waerden J AD - Sorbonne Universite, Inserm, Institut Pierre Louis d'Epidemiologie et de Sante Publique (IPLESP), Equipe de Recherche en Epidemiologie Sociale (ERES), Paris, 75012, France. FAU - Davidovic, Laetitia AU - Davidovic L AD - Universite Cote d'Azur, CNRS UMR7275, Inserm U1323, Institut de Pharmacologie Molecularie et Cellulaire, Valbonne, France. FAU - Charles, Marie-Aline AU - Charles MA AD - Universite Paris Cite and Universite Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics (CRESS), Paris, F-75004, France. ROR: https://ror.org/05f82e368 FAU - Galera, Cedric AU - Galera C AD - University of Bordeaux, Inserm, Bordeaux Population Health Center, UMR 1219, Bordeaux, France. AD - Centre Hospitalier Charles Perrens, Bordeaux, France. AD - Unit on Children's Psychosocial Maladjustment, Montreal, Canada. FAU - Heude, Barbara AU - Heude B AD - Universite Paris Cite and Universite Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics (CRESS), Paris, F-75004, France. ROR: https://ror.org/05f82e368 LA - eng PT - Journal Article DEP - 20260709 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM OTO - NOTNLM OT - Behavioural problems OT - Dietary inflammatory index OT - Inflammation OT - Life course OT - Pregnancy OT - Prenatal environment EDAT- 2026/07/09 06:33 MHDA- 2026/07/09 06:33 CRDT- 2026/07/09 01:43 PHST- 2026/07/09 06:33 [pubmed] PHST- 2026/07/09 06:33 [medline] PHST- 2026/07/09 01:43 [entrez] AID - S0007114526107879 [pii] AID - 10.1017/S0007114526107879 [doi] PST - aheadofprint SO - Br J Nutr. 2026 Jul 9:1-10. doi: 10.1017/S0007114526107879. PMID- 42420938 OWN - NLM STAT- MEDLINE DCOM- 20261006 LR - 20261008 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 8 TI - Reproducibility of an 85-item Child Food Frequency Questionnaire (85-item Child-FFQ) and diet quality scores among Polish children: The cross-sectional PITNUTS 2024 study. LID - 10.1186/s12887-026-07222-6 [doi] LID - 949 AB - BACKGROUND: Early childhood nutrition is crucial for long-term health; however, assessing dietary intake in young children is challenging due to the reliance on parent/caregiver reporting and the need for culturally relevant tools. The aim of this study (the Polish Infant and Toddler Nutrition Study, PITNUTS 2024) was to address this gap by developing and evaluating the reproducibility of a new 85-item Child Food Frequency Questionnaire (85-item Child-FFQ) and associated diet quality scores for Polish children aged 13-72 months. METHODS: A cross-sectional, nationally representative sample of 700 Polish children from two age groups (13-36 and 37-72 months) was recruited, and 100 children were randomly selected from each age group for the reproducibility study. The 85-item Child-FFQ was administered twice to the same parent as a proxy reporter. Three diet quality scores were developed: the children's pro-Healthy Diet Score, the children's non-Healthy Diet Score, the children's Ultra-Processed Food Score. Statistical analyses included comparisons of mean values for food consumption frequency and diet quality scores, cross-classification, kappa statistic, intraclass correlation coefficient (ICC), Spearman's correlation, and Bland-Altman plots. RESULTS: The 85-item Child-FFQ showed good test-retest reproducibility. Classification agreement for food consumption frequency ranged from 74% to 97% for children aged 13-36 months, and 77% to 95% for children aged 37-72 months. The kappa statistic indicated moderate to excellent agreement between test and retest of the FFQ. Diet quality scores demonstrated high reproducibility, with classification agreement ranging from 77% to 92%, the kappa statistic ranging from 0.62 to 0.86, and good to excellent correlation coefficients (ICC: 0.886-0.950, Spearman's r: 0.889-0.947). The Bland-Altman analysis revealed a small negative shift between test and retest of the diet quality scores and moderately wide limits of agreement. CONCLUSIONS: The newly developed 85-item Child-FFQ is a reliable tool for assessing habitual food consumption frequency and diet quality in Polish children aged 13-72 months. This tool has the potential to help monitor food consumption and diet quality variations over time, though this capacity needs to be validated through future longitudinal studies. TRIAL REGISTRATION: This trial was registered at www. CLINICALTRIALS: gov (NCT06417151, 16th May 2024). CI - (c) 2026. The Author(s). FAU - Sawicki, Michal AU - Sawicki M AD - Nutricia Foundation, 8 Bobrowiecka Street, Warsaw, 00-728, Poland. FAU - Kowalkowska, Joanna AU - Kowalkowska J AD - Department of Human Nutrition, Faculty of Food Science, University of Warmia and Mazury in Olsztyn, 45F Sloneczna Street, Olsztyn, 10-718, Poland. joanna.kowalkowska@uwm.edu.pl. FAU - Weker, Halina AU - Weker H AD - Department of Nutrition, Institute of Mother and Child, 17a Kasprzaka Street, Warsaw, 01-211, Poland. FAU - Wadolowska, Lidia AU - Wadolowska L AD - Department of Human Nutrition, Faculty of Food Science, University of Warmia and Mazury in Olsztyn, 45F Sloneczna Street, Olsztyn, 10-718, Poland. LA - eng SI - ClinicalTrials.gov/NCT06417151 GR - RG 1/2023/Nutricia Foundation/ PT - Journal Article PT - Observational Study DEP - 20260708 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Cross-Sectional Studies MH - *Diet MH - *Diet Surveys/methods MH - *Feeding Behavior MH - Poland MH - Reproducibility of Results MH - Surveys and Questionnaires PMC - PMC13640158 OTO - NOTNLM OT - Diet quality OT - Dietary assessment OT - Dietary pattern OT - Food frequency questionnaire OT - Nutrition OT - Preschoolers OT - Reliability OT - Reproducibility OT - Toddlers OT - Ultra-processed food COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Ethics Committee of the Institute of Mother and Child in Warsaw (ethics approval number: 40/2024). Informed consent was obtained from all parents-proxies involved in the study. Consent for publication: Not applicable. Competing interests: MS is an employee of the Nutricia Foundation that sponsored this study. EDAT- 2026/07/09 06:32 MHDA- 2026/10/06 05:29 PMCR- 2026/07/08 CRDT- 2026/07/09 00:19 PHST- 2026/02/27 00:00 [received] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/10/06 05:29 [medline] PHST- 2026/07/09 06:32 [pubmed] PHST- 2026/07/09 00:19 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - 10.1186/s12887-026-07222-6 [pii] AID - 7222 [pii] AID - 10.1186/s12887-026-07222-6 [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 8;26(1):949. doi: 10.1186/s12887-026-07222-6. PMID- 42419862 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 2632-1009 (Electronic) IS - 2632-1009 (Linking) VI - 33 IP - 1 DP - 2026 Jul 8 TI - Explainable machine learning revealing the impact of mental and physical health on arthritis. LID - 10.1136/bmjhci-2025-101955 [doi] LID - e101955 AB - OBJECTIVES: To develop a robust and interpretable machine learning framework for arthritis risk prediction and to identify important risk factors associated with the disease. METHODS: This study used four datasets, which are Behavioral Risk Factor Surveillance System (BRFSS) 2019, BRFSS 2021, National Health Interview Survey (NHIS) 2020 and NHIS 2022. We evaluated 11 machine learning and deep learning architectures including a custom stacked ensemble combined with five resampling techniques to address class imbalance and 9 imputation methods to handle missing data. Area under the receiver operating characteristic curve (AUROC), sensitivity, specificity and balanced accuracy are used to evaluate model performance, with fivefold cross-validation to ensure robustness. SHapley Additive exPlanations (SHAP) provided feature interpretability in prediction. RESULTS: The combination of the stacked ensemble, Generative Adversarial Network (GAN) imputation and random undersampling (RUS) achieved the best performance with an AUROC of 0.8007 and sensitivity of 0.8060 in the test set of BRFSS 2019. This combination also showed a balanced performance across both subgroups of male and female by maintaining high performance with AUROC of 0.808 and 0.800, respectively, in the test set of BRFSS 2021. The stacked ensemble model with GAN imputation and either Random Undersampling (RUS) or Random Oversampling (ROS) achieved the best performance across all four datasets. SHAP analysis identified higher age, walking difficulty and high body mass index (BMI) as the top physical factors. Among the psychosocial factors, parental separation showed a high impact on predicting arthritis. DISCUSSION: The risk of arthritis is influenced by health, lifestyle and childhood experiences. SHAP shows that difficulty walking, age, BMI and childhood stress play important roles in predicting arthritis risk. CONCLUSION: These results confirm important predictors of arthritis risk and provide a clear, interpretable framework. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Shams, Md Atik AU - Shams MA AUID- ORCID: 0009-0009-9984-058X AD - Department of Computer Science and Engineering, Notre Dame University Bangladesh, Dhaka, Bangladesh. AD - Department of Computer Science and Engineering, University of Asia Pacific, Dhaka, Bangladesh. FAU - Fatema, Sumaiya AU - Fatema S AUID- ORCID: 0009-0008-5662-314X AD - Department of Computer Science and Engineering, University of Asia Pacific, Dhaka, Bangladesh. FAU - Hasibul Islam, D M AU - Hasibul Islam DM AUID- ORCID: 0009-0002-0135-3169 AD - Department of Computer Science and Engineering, University of Asia Pacific, Dhaka, Bangladesh. FAU - Datta, Anindita AU - Datta A AD - Department of Fish and Wildlife Conservation, Virginia Tech, Blacksburg, Virginia, USA. FAU - Eisenberg, David AU - Eisenberg D AD - Department of Information Management and Business Analytics, Montclair State University, Montclair, New Jersey, USA. FAU - Tasaouf Mridula, Danastan AU - Tasaouf Mridula D AD - Department of Computer Science and Engineering, Northern University Bangladesh, Dhaka, Bangladesh. FAU - Mawa, Junnatul AU - Mawa J AD - Department of Computer Science and Engineering, University of Asia Pacific, Dhaka, Bangladesh. FAU - Sultana, Asma AU - Sultana A AUID- ORCID: 0009-0002-5306-5505 AD - Department of Computer Science and Engineering, University of Asia Pacific, Dhaka, Bangladesh. FAU - Ahmed, Nafiya AU - Ahmed N AD - Department of Computer Science, BRAC University, Dhaka, Bangladesh. FAU - Islam, Monowarul AU - Islam M AD - Department of Electrical and Electronic Engineering, Islamic University, Kushtia District, Bangladesh. FAU - Pias, Tanmoy Sarkar AU - Pias TS AUID- ORCID: 0000-0002-7325-9844 AD - Stanford Medicine, Stanford University, Stanford, California, USA tspias@stanford.edu. AD - Department of Computer Science, Virginia Tech, Blacksburg, Virginia, USA. LA - eng PT - Journal Article DEP - 20260708 PL - England TA - BMJ Health Care Inform JT - BMJ health & care informatics JID - 101745500 SB - IM MH - Humans MH - *Arthritis/epidemiology MH - *Machine Learning MH - Female MH - Risk Factors MH - Predictive Learning Models MH - *Mental Health MH - Male MH - *Health Status MH - Generative Adversarial Networks MH - Prediction Algorithms PMC - PMC13347896 OTO - NOTNLM OT - Artificial intelligence OT - BMJ Health Informatics OT - Public health informatics COIS- Competing interests: None declared. EDAT- 2026/07/09 04:10 MHDA- 2026/07/09 04:11 PMCR- 2026/07/08 CRDT- 2026/07/08 21:02 PHST- 2025/12/11 00:00 [received] PHST- 2026/06/21 00:00 [accepted] PHST- 2026/07/09 04:11 [medline] PHST- 2026/07/09 04:10 [pubmed] PHST- 2026/07/08 21:02 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - bmjhci-2025-101955 [pii] AID - 10.1136/bmjhci-2025-101955 [doi] PST - epublish SO - BMJ Health Care Inform. 2026 Jul 8;33(1):e101955. doi: 10.1136/bmjhci-2025-101955. PMID- 42419449 OWN - NLM STAT- Publisher LR - 20260716 IS - 1531-5037 (Electronic) IS - 0022-3468 (Linking) DP - 2026 Jul 8 TI - Assessing pediatric frailty: Use of the surgical complication index for pediatric patients (SCIPP) score to predict adverse outcomes following thoracic surgery. PG - 163288 LID - S0022-3468(26)00370-2 [pii] LID - 10.1016/j.jpedsurg.2026.163288 [doi] AB - INTRODUCTION: The Surgical Complication Index for Pediatric Patients (SCIPP) score, validated for use in pediatric neurosurgery, assesses seven components of frailty for a composite score: independence in performing activities of daily living (ADLs), autonomic function, body mass index (BMI), continence, previous admissions, mobility, and polypharmacy, while a reduced SCIPP score utilizes ADLs, autonomic function, and polypharmacy components. This study aimed to understand the predictive performance of full and reduced SCIPP score in children undergoing thoracic operations. METHODS: A single-center retrospective review of patients age 2-18 years undergoing thoracic surgery from 2020 to 2025 was conducted, excluding patients with missing components of SCIPP score. Full and reduced SCIPP scores were calculated. Operative details and postoperative outcomes with 1-month follow-up were collected. Multiple logistic regression assessed the association between SCIPP scores, complications, and length of stay (LOS). RESULTS: We included 317 patients. SCIPP scores were 0-1 in 70.7%, 2-3 in 18.0%, and 4+ in 11.4%. Logistic regression found that for every 1-point increase in full and reduced SCIPP scores, patients were 2.19 and 3.24 times more likely to have any complication, respectively (p < 0.001). LOS increased by 26% for each point greater in full SCIPP score and 44% for reduced SCIPP score (p < 0.001). CONCLUSION: The SCIPP score, a composite pediatric frailty index, can predict a patient's risk of complications and likelihood of increased LOS following thoracic surgery. There is a role for SCIPP score utilization, particularly the reduced score, in the preoperative setting to optimize parental counseling, risk assessment, and determination of prehabilitation needs. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Vincent, Sage A AU - Vincent SA AD - Division of Pediatric Surgery, Children's Hospital Colorado, 13123 E 16th Ave B323, Aurora CO, 80045, USA. Electronic address: Sage.Vincent@cuanschutz.edu. FAU - Easwaran, Lavanya AU - Easwaran L AD - Division of Pediatric Surgery, Children's Hospital Colorado, 13123 E 16th Ave B323, Aurora CO, 80045, USA; Department of Pediatrics, University of Colorado School of Medicine, Anschutz Medical Campus, 13123 E 16th Avenue, Aurora CO 80045, USA. FAU - Tong, Suhong AU - Tong S AD - Research Outcomes in Children's Surgery, Center for Children's Surgery, Children's Hospital Colorado, 13123 E 16th Ave, Aurora CO 80045, USA. FAU - Diaz-Miron, Jose AU - Diaz-Miron J AD - Division of Pediatric Surgery, Children's Hospital Colorado, 13123 E 16th Ave B323, Aurora CO, 80045, USA. FAU - Khurana, Eeshan AU - Khurana E AD - Sidney Kimmel Medical College, Thomas Jefferson University, 1025 Walnut St, Suite 100, Philadelphia PA 19107, USA. FAU - Mazzola, Catherine A AU - Mazzola CA AD - New Jersey Pediatric Neuroscience Institute, 131 Madison Ave, Morristown NJ 07960, USA. FAU - Acker, Shannon N AU - Acker SN AD - Division of Pediatric Surgery, Children's Hospital Colorado, 13123 E 16th Ave B323, Aurora CO, 80045, USA. LA - eng PT - Journal Article DEP - 20260708 PL - United States TA - J Pediatr Surg JT - Journal of pediatric surgery JID - 0052631 SB - IM OTO - NOTNLM OT - Complications OT - Frailty OT - Frailty score OT - Length of stay OT - Thoracic surgery COIS- Conflicts of interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Jose Diaz-Miron reports a relationship with MedCore Technologies Corporation that includes: consulting or advisory. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/09 04:10 MHDA- 2026/07/09 04:10 CRDT- 2026/07/08 19:11 PHST- 2026/03/16 00:00 [received] PHST- 2026/06/16 00:00 [revised] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/07/09 04:10 [pubmed] PHST- 2026/07/09 04:10 [medline] PHST- 2026/07/08 19:11 [entrez] AID - S0022-3468(26)00370-2 [pii] AID - 10.1016/j.jpedsurg.2026.163288 [doi] PST - aheadofprint SO - J Pediatr Surg. 2026 Jul 8:163288. doi: 10.1016/j.jpedsurg.2026.163288. PMID- 42419373 OWN - NLM STAT- MEDLINE DCOM- 20260821 LR - 20260821 IS - 1439-1899 (Electronic) IS - 0174-304X (Linking) VI - 57 IP - 4 DP - 2026 Aug TI - Primary Headache in Children: Clinical Characteristics and Impact on School Functioning in a Low-Resource Country. PG - 280-285 LID - 10.1055/a-2886-4833 [doi] AB - BACKGROUND: Primary headaches in children impair daily functioning, yet data from Jordan, particularly regarding their effect on school functioning, have not been systematically evaluated. OBJECTIVE: The objective of this study is to assess the clinical characteristics of pediatric primary headaches in central Jordan and their association with school functioning. METHODS: A cross-sectional study included children aged 5 to 18 years diagnosed with primary headaches at three public hospitals. Data were collected using a structured, culturally adapted questionnaire incorporating items from the validated Arabic PedsQL 4.0 school-functioning scale. Descriptive, univariable, and multivariable analyses were performed to identify factors associated with impaired school functioning. RESULTS: A total of 147 children were included (51% male; 61.2% aged 10-14 years). Migraine was most common (60.5%), followed by tension-type headache (23.8%). Common triggers included stress, noise, and sleep disturbance. Unfavorable lifestyle factors-increased screen time, skipped meals, low hydration, and limited physical activity-were prevalent. More than 92% of participants had impairment in at least one school-functioning domain. Poor academic performance and lower parental education were significantly associated with lower scores. In multivariable analysis, poorer academic performance and lower paternal education remained independently associated with worse school-functioning scores, whereas headache type and frequency were not significant predictors. Most patients used simple analgesics (paracetamol in 93%), whereas migraine-specific rescue medications and preventive therapies were rarely used. CONCLUSION: Primary headaches in children are associated with substantial impairment in school functioning. Educational and family-related factors appear more influential than headache-specific variables. Addressing modifiable lifestyle and contextual factors may improve outcomes. CI - Thieme. All rights reserved. FAU - Abu Libdeh, Amal AU - Abu Libdeh A AUID- ORCID: 0000-0001-5409-0230 AD - The University of Jordan, School of Medicine, Department of Pediatrics, Jordan, Amman. FAU - Alsubehat, Lara AU - Alsubehat L AUID- ORCID: 0009-0007-3621-3971 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Tabbalat, Nada AU - Tabbalat N AUID- ORCID: 0009-0006-6376-8131 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Mraish, Shahed AU - Mraish S AUID- ORCID: 0009-0004-9804-9845 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Al-Nawaiseh, Noura AU - Al-Nawaiseh N AUID- ORCID: 0009-0006-7756-2548 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Arabiyat, Nadine AU - Arabiyat N AUID- ORCID: 0009-0008-2397-3178 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Elayyan, Mustafa AU - Elayyan M AUID- ORCID: 0009-0004-2465-4436 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Al-Daraghmeh, Mohammad AU - Al-Daraghmeh M AUID- ORCID: 0009-0002-0316-0192 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Hussein, Hani AU - Hussein H AUID- ORCID: 0009-0006-8108-8025 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Deameh, Mohammad AU - Deameh M AUID- ORCID: 0009-0005-6197-3273 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Alshadfan, Lina AU - Alshadfan L AUID- ORCID: 0000-0003-4832-5149 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Masri, Amira AU - Masri A AUID- ORCID: 0000-0001-6103-8713 AD - The University of Jordan, School of Medicine, Department of Pediatrics, Jordan, Amman. LA - eng PT - Journal Article DEP - 20260708 PL - Germany TA - Neuropediatrics JT - Neuropediatrics JID - 8101187 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - Cross-Sectional Studies MH - Jordan/epidemiology MH - Adolescent MH - Child, Preschool MH - *Migraine Disorders/epidemiology MH - *Tension-Type Headache/epidemiology MH - *Academic Performance MH - Developing Countries COIS- The authors declare that they have no conflict of interest. EDAT- 2026/07/09 00:40 MHDA- 2026/08/21 23:37 CRDT- 2026/07/08 19:03 PHST- 2026/08/21 23:37 [medline] PHST- 2026/07/09 00:40 [pubmed] PHST- 2026/07/08 19:03 [entrez] AID - 10.1055/a-2886-4833 [doi] PST - ppublish SO - Neuropediatrics. 2026 Aug;57(4):280-285. doi: 10.1055/a-2886-4833. Epub 2026 Jul 8. PMID- 42419163 OWN - NLM STAT- MEDLINE DCOM- 20260812 LR - 20260812 IS - 1873-3360 (Electronic) IS - 0306-4530 (Linking) VI - 192 DP - 2026 Oct TI - Beyond a simple marker of stress: A multiverse analysis of biopsychosocial associations with hair cortisol and cortisone. PG - 107953 LID - S0306-4530(26)00213-1 [pii] LID - 10.1016/j.psyneuen.2026.107953 [doi] AB - BACKGROUND: Hair concentrations of cortisol and cortisone are increasingly used as potential biomarkers of chronic stress. However, their validity as indicators of psychosocial stress remains debated, as prior research shows variable associations with stress-related psychological and behavioral factors. This study systematically investigates a broad set of biopsychosocial correlates of hair glucocorticoids in young adults, leveraging a multiverse framework to evaluate the robustness of associations often reported as variable in prior work. METHODS: Using data from the Zurich Project on the Social Development from Childhood to Adulthood, a large community-based age cohort, we employed a multiverse analysis to explore relationships between more than 60 biological, psychological, and contextual variables and three hair-based outcomes (cortisol, cortisone, and a combined score of both) at ages 20 (n = 1,002) and 24 (n = 887). Specification curve analyses were performed on the full sample and separately by sex, systematically varying model choices (i.e., inclusion/exclusion of covariates). RESULTS: Hair characteristics (i.e., color, washing intensity, chemical treatment), sampling season, body mass index, and, among women, hormonal contraception, showed strong associations with glucocorticoids and were included as covariates. Sweating intensity was associated with glucocorticoids primarily in females, but not in males. Hair concentrations of drugs (i.e., Delta9-tetrahydrocannabinol, cocaine, 3,4-methylenedioxymethamphetamine [MDMA, "Ecstasy"], paracetamol) and the hormone testosterone were consistently linked to steroid outcomes. Several psychosocial factors were associated with hair glucocorticoids: migration background, perceived stress, symptoms of anxiety/depression, sports activity, and social exclusion. These factors exhibited stronger correlations with cortisol, while media use, aggression, and effective coping were more closely associated with cortisone. The combined steroid score mainly reflected associations detected for cortisol, but with weaker effect sizes. Associations varied descriptively by age and sex, with more associations detected in males at age 20 and in females at age 24. CONCLUSION: In cohort studies, corticosteroids in hair can reflect specific facets of psychosocial stress when critical confounders and sex are considered. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Janousch, Clarissa AU - Janousch C AD - Experimental Pharmacopsychology and Psychological Addiction Research, Department of Adult Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland; Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland; Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. Electronic address: clarissa.janousch@ki.se. FAU - Eggenberger, Lukas AU - Eggenberger L AD - Experimental Pharmacopsychology and Psychological Addiction Research, Department of Adult Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland; Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland. FAU - Johnson-Ferguson, Lydia AU - Johnson-Ferguson L AD - Experimental Pharmacopsychology and Psychological Addiction Research, Department of Adult Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland; Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland; Suchtfachstelle Zurich, Zurich, Switzerland. FAU - Voegel, Clarissa D AU - Voegel CD AD - Center for Forensic Hair Analytics, Zurich Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland. FAU - Baumgartner, Markus R AU - Baumgartner MR AD - Center for Forensic Hair Analytics, Zurich Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland. FAU - Ribeaud, Denis AU - Ribeaud D AD - Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland. FAU - Eisner, Manuel AU - Eisner M AD - Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland; Institute of Criminology, University of Cambridge, Cambridge, United Kingdom. FAU - Binz, Tina M AU - Binz TM AD - Center for Forensic Hair Analytics, Zurich Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland. FAU - Shanahan, Lilly AU - Shanahan L AD - Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland; Institute of Psychology, University of Zurich, Zurich, Switzerland. FAU - Quednow, Boris B AU - Quednow BB AD - Experimental Pharmacopsychology and Psychological Addiction Research, Department of Adult Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland; Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland. LA - eng PT - Journal Article DEP - 20260703 PL - England TA - Psychoneuroendocrinology JT - Psychoneuroendocrinology JID - 7612148 RN - V27W9254FZ (Cortisone) RN - WI4X0X7BPJ (Hydrocortisone) RN - 0 (Biomarkers) RN - 0 (Glucocorticoids) SB - IM MH - Humans MH - *Cortisone/analysis/metabolism MH - Female MH - *Hair/chemistry MH - *Hydrocortisone/analysis/metabolism MH - Male MH - *Stress, Psychological/metabolism MH - Biomarkers/analysis MH - Young Adult MH - Cohort Studies MH - Glucocorticoids/analysis MH - Adult OTO - NOTNLM OT - Allostatic load OT - Deep phenotyping OT - Glucocorticoids OT - Hair cortisol OT - Inflammation OT - Specification curve analysis COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/09 04:10 MHDA- 2026/08/12 23:34 CRDT- 2026/07/08 18:09 PHST- 2026/01/20 00:00 [received] PHST- 2026/06/30 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/08/12 23:34 [medline] PHST- 2026/07/09 04:10 [pubmed] PHST- 2026/07/08 18:09 [entrez] AID - S0306-4530(26)00213-1 [pii] AID - 10.1016/j.psyneuen.2026.107953 [doi] PST - ppublish SO - Psychoneuroendocrinology. 2026 Oct;192:107953. doi: 10.1016/j.psyneuen.2026.107953. Epub 2026 Jul 3. PMID- 42418464 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Development and psychometric evaluation of the Spanish Cooking Self-Efficacy Questionnaire (SCSEQ) for Spanish University Students. PG - e0352758 LID - 10.1371/journal.pone.0352758 [doi] LID - e0352758 AB - The transition to university is a critical life stage characterized by increased autonomy, identity exploration, and new social and environmental influences. During this period, university students often exhibit low adherence to dietary guidelines. Among the determinants influencing healthy eating, cooking self-efficacy, the central construct of Social Cognitive Theory (SCT), is consistently associated with improved diet quality and is a frequent target of health interventions. However, no validated instrument exists to assess this construct among university students in Spain. Therefore, the goal was to develop and provide preliminary evidence of the Spanish Cooking Self-Efficacy Questionnaire (SCSEQ), a concise SCT-based instrument tailored to Mediterranean university settings. A 32-item questionnaire was developed through a review of existing instruments assessing cooking self-efficacy. Face validity was evaluated with Spanish food and nutrition experts (n = 12) to assess the clarity and pertinence of the initial items. The revised Spanish Cooking Self-Efficacy Questionnaire (SCSEQ) was then pilot-tested with Spanish university students (n = 73) from four Catalan universities. Exploratory factor analysis (EFA) was conducted to identify the underlying factor structure and detect problematic items. Internal consistency reliability was assessed using McDonald's omega, and test-retest reliability over a two-week interval was evaluated using Pearson correlations. Face validity indicated overall clarity and adequacy. Four items were excluded and recombined, two items were added, and nine items were rewritten based on experts' feedback. After pilot testing, the questionnaire overall demonstrated high internal consistency (omega = 0.9). Items were reviewed based on factor loadings, item redundancy, theoretical relevance, and their contribution to scale-level internal consistency. EFA suggested a two-factor structure with good internal consistency (omega = 0.88 and omega = 0.82) and test-retest reliability (ICC = 0.91, 95% CI [0.80, 0.96]). Three items with weak loadings were excluded. The final version consisted of 25 items and 2 subscales. The SCSEQ showed favorable preliminary psychometric properties. CI - Copyright: (c) 2026 Jurado-Gonzalez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Jurado-Gonzalez, Patricia AU - Jurado-Gonzalez P AUID- ORCID: 0000-0003-0632-0390 AD - NUTRALiSS, Faculty of Health Sciences, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. FAU - Medina, F Xavier AU - Medina FX AUID- ORCID: 0000-0002-8067-355X AD - Epi4Health Research Group, Faculty of Health Sciences, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. AD - UNESCO Chair on Food, Culture and Development, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. FAU - Martinez-Garcia, Alba AU - Martinez-Garcia A AD - Department of Community Nursing, Preventive Medicine, Public Health and History of Science, University of Alicante, Alicante, Spain. FAU - Lopez-Cediel Verdu, Almudena AU - Lopez-Cediel Verdu A AD - Talent Data Scientist, Data Scientist and Psychometric Specialist, Madrid, Spain. FAU - Fabregues, Sergi AU - Fabregues S AUID- ORCID: 0000-0003-1141-7613 AD - NUTRALiSS, Faculty of Health Sciences, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. AD - Department of Psychology and Education, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. FAU - Bach-Faig, Anna AU - Bach-Faig A AD - NUTRALiSS, Faculty of Health Sciences, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. LA - eng PT - Journal Article DEP - 20260708 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Students/psychology MH - *Self Efficacy MH - *Psychometrics/methods MH - Female MH - Spain MH - *Cooking MH - Male MH - Universities MH - Surveys and Questionnaires MH - Young Adult MH - Adult MH - Reproducibility of Results MH - Adolescent PMC - PMC13345255 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/08 18:52 MHDA- 2026/07/08 18:53 PMCR- 2026/07/08 CRDT- 2026/07/08 13:43 PHST- 2026/04/25 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/07/08 18:53 [medline] PHST- 2026/07/08 18:52 [pubmed] PHST- 2026/07/08 13:43 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - PONE-D-26-19104 [pii] AID - 10.1371/journal.pone.0352758 [doi] PST - epublish SO - PLoS One. 2026 Jul 8;21(7):e0352758. doi: 10.1371/journal.pone.0352758. eCollection 2026. PMID- 42418453 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Knowledge, attitudes, and practices regarding type 2 diabetes and associated factors among rural adolescents in Indonesia: A cross-sectional study. PG - e0352982 LID - 10.1371/journal.pone.0352982 [doi] LID - e0352982 AB - INTRODUCTION: Type 2 diabetes (T2D) is an increasingly important public health concern in Indonesia and is increasingly affecting adolescents at a growing rate due to lifestyle transitions and limited awareness. Evidence regarding adolescents' knowledge, attitudes, and practices (KAP) toward T2D in rural settings remains limited. This study assessed KAP levels related to T2D, identified sociodemographic factors associated with KAP outcomes, and examined interrelationships among KAP domains among rural Indonesian adolescents. METHODS: A cross-sectional study was conducted from September 2024 to February 2025 among 1,546 senior high school students in Kampar Regency, Riau Province. Participants were selected using multistage cluster sampling. Data were collected using a validated KAP questionnaire (Cronbach's alpha = 0.725). Descriptive and inferential statistics, including Mann-Whitney U tests, Kruskal-Wallis tests, Spearman's rank correlations, and multiple linear regression analyses, were used to examine KAP outcomes and associated factors. RESULTS: Participants demonstrated limited knowledge regarding T2D, particularly related to risk factors, symptoms, and complications. Although attitudes toward diabetes prevention were generally positive, preventive practices remained suboptimal, especially regarding physical activity. Female gender, peri-urban school location, higher academic rank, extracurricular participation, and prior exposure to diabetes information were associated with higher KAP scores. Knowledge was moderately associated with attitude but only weakly associated with preventive practices. CONCLUSIONS: Rural adolescents demonstrated limited diabetes-related knowledge and suboptimal preventive behaviors despite generally positive attitudes toward T2D prevention. Several sociodemographic and school-related factors were associated with KAP outcomes. However, the weak relationship between knowledge and practice highlights a persistent gap between awareness and preventive behavior. School-based, peer-led, and after-school interventions that integrate education with behavioral reinforcement may strengthen diabetes prevention efforts among rural adolescents. CI - Copyright: (c) 2026 Kusumawati et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Kusumawati, Nila AU - Kusumawati N AUID- ORCID: 0000-0002-0967-228X AD - Department of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, United States of America. AD - Indonesian Diabetes Center, Universitas Pahlawan Tuanku Tambusai, Kampar, Riau Province, Indonesia. FAU - Pijl, Hanno AU - Pijl H AD - Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands. FAU - Alaofe, Halimatou AU - Alaofe H AUID- ORCID: 0000-0002-3011-9673 AD - Department of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, United States of America. FAU - Yani, Emul AU - Yani E AD - Faculty of Nursing, Institut Kesehatan Payung Negeri Pekanbaru, Pekanbaru, Riau Province, Indonesia. FAU - Puswati, Desti AU - Puswati D AD - Faculty of Nursing, Institut Kesehatan Payung Negeri Pekanbaru, Pekanbaru, Riau Province, Indonesia. FAU - Hamid, Abdul AU - Hamid A AD - Indonesian Diabetes Center, Universitas Pahlawan Tuanku Tambusai, Kampar, Riau Province, Indonesia. LA - eng PT - Journal Article DEP - 20260708 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - Adolescent MH - Male MH - *Health Knowledge, Attitudes, Practice MH - *Diabetes Mellitus, Type 2/epidemiology/prevention & control/psychology MH - Cross-Sectional Studies MH - Indonesia/epidemiology MH - Rural Population MH - Surveys and Questionnaires MH - Risk Factors PMC - PMC13345253 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/08 18:52 MHDA- 2026/07/08 18:53 PMCR- 2026/07/08 CRDT- 2026/07/08 13:43 PHST- 2025/11/27 00:00 [received] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/07/08 18:53 [medline] PHST- 2026/07/08 18:52 [pubmed] PHST- 2026/07/08 13:43 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - PONE-D-25-61411 [pii] AID - 10.1371/journal.pone.0352982 [doi] PST - epublish SO - PLoS One. 2026 Jul 8;21(7):e0352982. doi: 10.1371/journal.pone.0352982. eCollection 2026. PMID- 42417925 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20261008 IS - 0973-7693 (Electronic) IS - 0019-5456 (Linking) VI - 93 IP - 9 DP - 2026 Sep TI - A Simple Clinical Prediction Model for Metabolic Dysfunction-Associated Steatotic Liver Disease in Adolescents with Obesity. PG - 933-938 LID - 10.1007/s12098-026-06301-x [doi] AB - OBJECTIVES: To develop and validate a simple, office-based screening tool for metabolic dysfunction-associated steatotic liver disease (MASLD) in adolescents with obesity using readily available clinical indicators. METHODS: This cross-sectional study utilized NHANES 2021-2023 data (derivation cohort, n = 100) and 2017-2020 data (temporal validation cohort, n = 149). MASLD was defined as controlled attenuation parameter (CAP) >/=245 dB/m. Model performance was assessed using area under the receiver operating characteristic curve (AUC). RESULTS: A simplified three-variable model incorporating alanine aminotransferase (ALT), triglycerides, and waist circumference demonstrated excellent discrimination (AUC 0.809, 95% CI: 0.721-0.897) in derivation and remained robust in validation (AUC 0.725, 95% CI: 0.636-0.814). Inclusion of homeostasis model assessment of insulin resistance (HOMA-IR) did not significantly improve performance (DeLong P >0.05). CONCLUSIONS: This validated three-parameter model requires no specialized tests or insulin measurement, providing a practical tool for frontline pediatricians to stratify MASLD risk during routine visits. CI - (c) 2026. The Author(s), under exclusive licence to Dr. K C Chaudhuri Foundation. FAU - Liao, Yang AU - Liao Y AUID- ORCID: 0009-0002-9412-4487 AD - Department of Pediatrics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai, 201399, China. dr_liaoyang@163.com. FAU - Wang, Fei AU - Wang F AD - Department of Pediatrics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai, 201399, China. FAU - Tian, Ting-Ting AU - Tian TT AD - Department of Pediatrics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai, 201399, China. FAU - Li, Xiu-Fen AU - Li XF AD - Department of Pediatrics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai, 201399, China. LA - eng PT - Journal Article DEP - 20260708 PL - India TA - Indian J Pediatr JT - Indian journal of pediatrics JID - 0417442 RN - EC 2.6.1.2 (Alanine Transaminase) RN - 0 (Triglycerides) SB - IM MH - Humans MH - Cross-Sectional Studies MH - Adolescent MH - Female MH - Male MH - *Fatty Liver/diagnosis/etiology MH - Alanine Transaminase/blood MH - *Pediatric Obesity/complications MH - Triglycerides/blood MH - Insulin Resistance MH - Nutrition Surveys MH - Waist Circumference OTO - NOTNLM OT - Adolescent OT - Alanine aminotransferase OT - Metabolic dysfunction-associated steatotic liver disease OT - Pediatric obesity OT - Screening tool OT - Triglycerides OT - Waist circumference COIS- Declarations. Conflict of Interest: None. EDAT- 2026/07/08 12:56 MHDA- 2026/08/28 11:46 CRDT- 2026/07/08 11:06 PHST- 2026/02/19 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/08/28 11:46 [medline] PHST- 2026/07/08 12:56 [pubmed] PHST- 2026/07/08 11:06 [entrez] AID - 10.1007/s12098-026-06301-x [pii] AID - 10.1007/s12098-026-06301-x [doi] PST - ppublish SO - Indian J Pediatr. 2026 Sep;93(9):933-938. doi: 10.1007/s12098-026-06301-x. Epub 2026 Jul 8. PMID- 42416279 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 2235-2988 (Electronic) IS - 2235-2988 (Linking) VI - 16 DP - 2026 TI - Rapid and low-cost detection of six major pediatric enteric pathogens using a closed-tube PCR-invasive reaction assay. PG - 1841155 LID - 10.3389/fcimb.2026.1841155 [doi] LID - 1841155 AB - Diarrhea caused by bacterial and viral pathogens remains a major cause of childhood morbidity and mortality, leading to dehydration, malnutrition, and substantial healthcare burdens; rapid and accurate diagnosis is therefore essential for timely treatment. In clinical practice, detection still commonly relies on traditional methods such as stool culture and enzyme-linked immunosorbent assays. These approaches are not only time-consuming and lack sensitivity but also typically require separate, pathogen-specific tests, complicating comprehensive diagnosis. While quantitative PCR (qPCR) offers speed and sensitivity, dye-based methods lack specificity, and fluorescent probe-based assays are costly. To address these limitations, we developed an integrated assay that combines PCR with a sequence-specific invasive reaction (Invader) in a single closed tube. This method detects six major pediatric enteric pathogens: Shigella spp., Vibrio cholerae, non-typhoidal Salmonella, Campylobacter jejuni, rotavirus, and enteric adenovirus (types 40/41). The assay demonstrated high sensitivity, with detection limits as low as 2 copies per reaction for each target and exhibited no cross-reactivity. The entire process was completed within 45 minutes. By employing universal Invader probes, we reduced the cost per test to approximately 2 RMB. Validation using both simulated and clinical stool samples suggested the assay's potential reliability and consistency with standard methods. This closed-tube PCR-Invader assay provides a rapid, cost-effective, and unified platform for the parallel detection of six major diarrheal pathogens in a single test run. It shows promise as a practical alternative to current disparate and pathogen-specific testing strategies, with considerable potential for use in primary healthcare settings and large-scale screening to guide the management of childhood infectious diarrhea. CI - Copyright (c) 2026 Yang, Zhou, Zhang, Huang, Kong, Zheng, Zhang, Shen, Han, Liu and Lu. FAU - Yang, Nan AU - Yang N AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Zhou, Jin AU - Zhou J AD - Department of Clinical Laboratory, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Zhang, Han AU - Zhang H AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Huang, Yihsuan AU - Huang Y AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Kong, Guiping AU - Kong G AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Zheng, Yucan AU - Zheng Y AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Zhang, Zhuo AU - Zhang Z AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Shen, Ying AU - Shen Y AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Han, Xiu AU - Han X AD - School of Basic Medical Sciences, Faculty of Medicine, Yangzhou University, Yangzhou, China. FAU - Liu, Zhifeng AU - Liu Z AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Lu, Yan AU - Lu Y AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. LA - eng PT - Journal Article DEP - 20260623 PL - Switzerland TA - Front Cell Infect Microbiol JT - Frontiers in cellular and infection microbiology JID - 101585359 SB - IM MH - Humans MH - Sensitivity and Specificity MH - *Molecular Diagnostic Techniques/methods/economics MH - *Polymerase Chain Reaction/methods/economics MH - *Diarrhea/diagnosis/virology/microbiology MH - Campylobacter jejuni/isolation & purification/genetics MH - Feces/virology/microbiology MH - Rotavirus/isolation & purification/genetics MH - Vibrio cholerae/isolation & purification/genetics MH - Shigella/isolation & purification/genetics MH - Rapid Diagnostic Tests PMC - PMC13337639 OTO - NOTNLM OT - closed-tube assay OT - co-infection detection OT - enteric pathogens OT - invasive reaction OT - rapid and low-cost detection COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/08 06:52 MHDA- 2026/07/08 20:04 PMCR- 2026/06/23 CRDT- 2026/07/08 04:40 PHST- 2026/03/28 00:00 [received] PHST- 2026/05/31 00:00 [revised] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/07/08 20:04 [medline] PHST- 2026/07/08 06:52 [pubmed] PHST- 2026/07/08 04:40 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - 10.3389/fcimb.2026.1841155 [doi] PST - epublish SO - Front Cell Infect Microbiol. 2026 Jun 23;16:1841155. doi: 10.3389/fcimb.2026.1841155. eCollection 2026. PMID- 42415218 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260910 LR - 20260911 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 14 IP - 1 DP - 2026 Jul 7 TI - Prevalence and clinical correlates of avoidant/restrictive food intake disorder in children and adolescents with Celiac disease: a cross-sectional study. LID - 10.1186/s40337-026-01699-3 [doi] LID - 212 AB - BACKGROUND: Avoidant/Restrictive Food Intake Disorder (ARFID) may represent a clinically important problem in celiac disease (CD), where lifelong dietary restriction, ongoing gastrointestinal symptoms, and food-related anxiety may promote food avoidance beyond gluten-containing foods and contribute to maladaptive eating patterns. Although adult studies have reported high rates of ARFID symptoms in CD, pediatric data are limited. This study aimed to evaluate the prevalence and clinical correlates of ARFID in children and adolescents with CD using a multidisciplinary assessment approach involving pediatric gastroenterology and child and adolescent psychiatry specialists, including anthropometric, nutritional, bone health, psychological, and health-related quality-of-life (QoL) correlates. METHODS: A cross-sectional study was conducted at a tertiary-care center involving children and adolescents aged 8-17 years with biopsy-confirmed CD (n = 101). Participants were assessed using a combination of clinical interviews and psychometric scales, including the Nine Item ARFID Screen (NIAS), the Revised Child Anxiety and Depression Scale (RCADS), and the Pediatric QoL Inventory (PedsQL). ARFID diagnosis was established through a DSM-5-guided clinical evaluation by two child and adolescent psychiatrists, and clinical and anthropometric data were collected alongside laboratory results. Multivariable regression models were used to identify factors independently associated with ARFID and clinical outcomes. RESULTS: The prevalence of ARFID in the cohort was 42.6%. Children with ARFID exhibited significantly lower weight and BMI z-scores (p < 0.001 and p = 0.002, respectively), a higher prevalence of osteopenia/osteoporosis (p = 0.005) and micronutrient deficiencies (p < 0.001), poorer QoL (p < 0.001), and higher anxiety and depressive symptom scores (p < 0.001 and p = 0.003, respectively). Presence of gastrointestinal symptoms and higher anxiety score were independently associated with ARFID in children and adolescents with CD. CONCLUSION: In this cohort, ARFID appeared to be a clinically relevant comorbidity in pediatric CD, with adverse physical and psychosocial correlates. Restrictive eating extending beyond gluten avoidance should be recognized during clinical assessment, particularly in children with gastrointestinal symptoms, prominent anxiety symptoms, poor weight gain, or persistent micronutrient deficiencies. Longitudinal studies are needed to clarify the clinical course of ARFID symptoms and to inform targeted multidisciplinary care in this population. CI - (c) 2026. The Author(s). FAU - Teke, Halenur AU - Teke H AUID- ORCID: 0009-0001-0143-3890 AD - Department of Child and Adolescent Psychiatry, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. drhalenurteke@gmail.com. FAU - Sogut, Aydan AU - Sogut A AD - Department of Child and Adolescent Psychiatry, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Mavi, Hilal Tuter AU - Mavi HT AD - Department of Child and Adolescent Psychiatry, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Teke, Selcuk AU - Teke S AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Ergen, Yasin Maruf AU - Ergen YM AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Akcay, Birce Izgi AU - Akcay BI AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Celebi, Seda Bozduman AU - Celebi SB AD - Department of Child and Adolescent Psychiatry, Basaksehir Cam ve Sakura City Hospital, Istanbul, Turkiye. FAU - Congologlu, Mehmet Ayhan AU - Congologlu MA AD - Department of Child and Adolescent Psychiatry, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Balamtekin, Necati AU - Balamtekin N AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260707 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC13556089 OAB - Celiac disease requires lifelong treatment with a strict gluten-free diet. In some children and adolescents, eating difficulties may extend beyond avoiding gluten and develop into avoidant/restrictive food intake disorder (ARFID), an eating disorder marked by very limited eating that is not driven by body image concerns. In celiac disease, ongoing digestive symptoms, fear of symptoms after gluten exposure, and the burden of following a strict diet may increase vulnerability to this problem. This study examined how common ARFID was in young people with celiac disease and explored its clinical features. ARFID was identified in 42.6% of the study group. Children and adolescents with ARFID had lower weight, more nutritional problems, weaker bone health, more anxiety and depression symptoms, and lower quality of life than those without ARFID. Ongoing gastrointestinal symptoms and higher anxiety symptoms were the factors most strongly linked with ARFID. These findings suggest that when food restriction extends beyond medically necessary dietary rules, it may indicate a more serious eating problem with both physical and emotional effects. Care for young people with celiac disease may benefit from a multidisciplinary approach that includes pediatric gastroenterology, child and adolescent psychiatry, dietetics, and psychological support. OABL- eng OTO - NOTNLM OT - Anxiety OT - Avoidant/Restrictive food intake disorder (ARFID) OT - Bone mineral density OT - Gluten-free diet OT - Pediatric celiac disease COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Scientific Research Ethics Committee of the University of Health Sciences, Gulhane Training and Research Hospital (Decision No: 2025/182, Decision Date: 11.09.2025). Written informed consent was obtained from all participants and their parents or legal guardians after providing a comprehensive explanation of the study aims and procedures. All study procedures adhered to the ethical standards set forth in the Declaration of Helsinki. Competing interests: The authors declare no competing interests. EDAT- 2026/07/08 02:00 MHDA- 2026/07/08 02:01 PMCR- 2026/07/07 CRDT- 2026/07/08 00:00 PHST- 2026/03/17 00:00 [received] PHST- 2026/06/27 00:00 [accepted] PHST- 2026/07/08 02:01 [medline] PHST- 2026/07/08 02:00 [pubmed] PHST- 2026/07/08 00:00 [entrez] PHST- 2026/07/07 00:00 [pmc-release] AID - 10.1186/s40337-026-01699-3 [pii] AID - 1699 [pii] AID - 10.1186/s40337-026-01699-3 [doi] PST - epublish SO - J Eat Disord. 2026 Jul 7;14(1):212. doi: 10.1186/s40337-026-01699-3. PMID- 42413912 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260925 IS - 1543-5474 (Electronic) IS - 1543-3080 (Linking) VI - 23 IP - 10 DP - 2026 Oct 1 TI - Are Active Schools Associated With Active Commuting? Examining the Prevalence and Determinants in Young People. PG - 1444-1452 LID - 10.1123/jpah.2025-0724 [doi] AB - BACKGROUND: This study aimed to determine the prevalence of active commuting to school among children and adolescents in the Valencian Community (Spain) and to examine potential differences according to sociodemographic, institutional, and behavioral variables. METHODS: A total of 2232 students (8-18 y; 52.2% girls) from 20 schools participated. Sociodemographic (gender, educational stage, socioeconomic status), environmental (type of school: Active vs Non-Active), and behavioral (physical activity levels) variables were assessed using validated self-report instruments. Descriptive and bivariate analyses were conducted using Rao-Scott-adjusted chi-square tests for complex samples, and associations between commuting modes and study variables were subsequently examined using cluster-adjusted generalized estimating equations. RESULTS: Overall, 69% of students actively commuted to and from school. Significant differences were observed by gender and socioeconomic status, whereas no differences were found by educational stage, school type, or physical activity level. When commuting modes were examined, walking was the predominant behavior while cycling was rare (1.3%). Boys and students from lower-income households were more likely to walk, and boys were also more likely than girls to cycle. CONCLUSIONS: The study reveals that most students engage in active commuting to school, mainly by walking, although significant disparities persist according to sociodemographic variables. These findings highlight the need for future research to explore the specific barriers and facilitators of active commuting to school in young people, particularly among girls. They also support the implementation and systematic evaluation of school-based strategies designed to reduce these disparities and promote active, healthy, and sustainable mobility within the school. FAU - Sanchis-Frances, Lucia AU - Sanchis-Frances L AUID- ORCID: 0009-0008-9197-480X AD - Universitat de Valencia, Valencia, Spain. FAU - Valencia-Peris, Alexandra AU - Valencia-Peris A AUID- ORCID: 0000-0002-2031-9743 AD - Universitat de Valencia, Valencia, Spain. FAU - Ferriz, Roberto AU - Ferriz R AUID- ORCID: 0000-0001-7041-4098 AD - Universitat de Valencia, Valencia, Spain. FAU - Lizandra, Jorge AU - Lizandra J AUID- ORCID: 0000-0001-5599-133X AD - Universitat de Valencia, Valencia, Spain. LA - eng PT - Journal Article DEP - 20260707 PL - United States TA - J Phys Act Health JT - Journal of physical activity & health JID - 101189457 SB - IM MH - Humans MH - Female MH - Adolescent MH - *Transportation/methods/statistics & numerical data MH - Male MH - Child MH - *Bicycling/statistics & numerical data MH - Walking/statistics & numerical data MH - *Schools/statistics & numerical data MH - Spain MH - Socioeconomic Factors MH - Students/statistics & numerical data MH - *Exercise MH - Sex Factors MH - Sociodemographic Factors OTO - NOTNLM OT - active transport OT - physical activity OT - program evaluation OT - youth EDAT- 2026/07/08 01:48 MHDA- 2026/09/25 17:32 CRDT- 2026/07/07 19:33 PHST- 2025/09/25 00:00 [received] PHST- 2026/04/30 00:00 [revised] PHST- 2026/05/02 00:00 [accepted] PHST- 2026/09/25 17:32 [medline] PHST- 2026/07/08 01:48 [pubmed] PHST- 2026/07/07 19:33 [entrez] AID - 10.1123/jpah.2025-0724 [doi] PST - epublish SO - J Phys Act Health. 2026 Jul 7;23(10):1444-1452. doi: 10.1123/jpah.2025-0724. Print 2026 Oct 1. PMID- 42412896 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Longitudinal associations of academic stress with eating related patterns, nutrition, somatic indicators, and depressive symptoms in university students: A study protocol. PG - e0352779 LID - 10.1371/journal.pone.0352779 [doi] LID - e0352779 AB - INTRODUCTION: Academic stress (AS) can be understood as a multidimensional form of chronic stress that has been linked to adverse patterns across physical and mental health in university students. This protocol outlines a longitudinal, observational study to examine within-semester associations between AS and indicators of nutritional status, eating-related patterns, sleep quality, and depressive symptoms. By integrating physiological, behavioral, and psychological indicators within a repeated-measures framework, the study aims to generate evidence that can inform prevention-focused actions and early support strategies in university health contexts. HYPOTHESES: (i) Higher AS will be longitudinally associated with less favorable eating-related patterns, nutritional and somatic indicators, and higher depressive symptoms in university students. (ii) Higher AS will be associated with altered post-awakening cortisol dynamics, specifically a lower cortisol awakening response (CAR) and lower AUCi, together with a higher AUCg, and with higher salivary alpha-amylase (sAA) levels, consistent with stress-related activation of HPA-axis and sympathetic pathways. DESIGN AND PARTICIPANTS: A longitudinal, observational, nonexperimental design with repeated measurements will be implemented across three assessment cycles during an academic semester. A feasibility-based convenience sample will be recruited from undergraduate students (2nd to 4th year) enrolled in the Faculty of Medicine, University of Concepcion (Chile). Students receiving psychological or pharmacological treatment will be eligible to reflect real-world heterogeneity and support ecological validity. METHODS: Data will be collected through standardized questionnaires, nutritional assessments, biological sampling, and wearable-derived somatic indicators. Electronic surveys administered via REDCap will assess AS, perceived stress, eating-related patterns, and depressive symptoms. Diet will be assessed through interviewer-administered nutritional interviews, including repeated 24-hour dietary recalls treated as time-specific observations and modeled longitudinally as time-varying measures, and complemented by diet-quality and dietary inflammatory potential indices. Wearable devices will record nonclinical somatic indicators, including heart rate, oxygen saturation, and sleep-related metrics during monitoring periods. Saliva will be collected twice per week during each assessment cycle to quantify salivary cortisol dynamics and sAA activity, and peripheral blood samples obtained at baseline and end of semester will be used to determine lipid profile, fasting glucose, albumin, globulin, and total proteins. STATISTICAL ANALYSIS: Analyses will include descriptive and bivariate summaries, followed by multivariable models appropriate to outcome type. Longitudinal associations will be examined using mixed-effects models, and temporal cross-lagged associations will be explored using random-intercept cross-lagged panel models across the three assessment cycles. All inferences will be framed as associational given the observational design. EXPECTED RESULTS: Rather than prespecifying outcomes, this protocol is expected to generate longitudinal evidence on how within-semester variation in AS aligns with eating-related patterns, diet, nutritional and somatic indicators, depressive symptoms, and stress-related physiological indicators (salivary cortisol dynamics and sAA activity). The integrated, feasibility-oriented measurement framework may serve as a replicable template for future research and inform prevention-focused actions to support student well-being in university settings. CI - Copyright: (c) 2026 Rojas-Cardenas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Rojas-Cardenas, Pia AU - Rojas-Cardenas P AUID- ORCID: 0000-0002-6208-0830 AD - Programa de Doctorado en Salud Mental, Facultad de Medicina, Universidad de Concepcion, Concepcion, Chile. AD - Carrera de Nutricion y Dietetica, Facultad de Ciencias de la Salud, Universidad Adventista de Chile, Nuble, Chile. FAU - Nazar, Gabriela AU - Nazar G AD - Departamento de Psicologia, Facultad de Ciencias Sociales, Universidad de Concepcion, Concepcion, Chile. FAU - Castillo-Navarrete, Juan Luis AU - Castillo-Navarrete JL AUID- ORCID: 0000-0002-7401-2384 AD - Programa de Doctorado en Salud Mental, Facultad de Medicina, Universidad de Concepcion, Concepcion, Chile. AD - Departamento de Tecnologia Medica, Facultad de Medicina, Universidad de Concepcion, Concepcion, Chile. AD - Programa de Neurociencia, Psiquiatria y Salud Mental, NEPSAM, Universidad de Concepcion, Concepcion, Chile. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20260707 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - WI4X0X7BPJ (Hydrocortisone) SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Young Adult MH - Cortisol Awakening Response MH - *Depression/psychology/physiopathology MH - *Feeding Behavior/psychology MH - Hydrocortisone/metabolism MH - Longitudinal Studies MH - *Nutritional Status MH - Saliva/metabolism MH - Sleep Quality MH - *Stress, Psychological/psychology/physiopathology/metabolism MH - *Students/psychology MH - Universities MH - Observational Studies as Topic PMC - PMC13340845 COIS- The authors declare no competing interests. Funding was provided by Agencia Nacional de Investigacion y Desarrollo (ANID), Chile: FONDECYT Iniciacion No. 11240383 (recipient: Juan Luis Castillo-Navarrete) and ANID Doctoral Scholarship No. 1340/2025 (recipient: Pia Rojas-Cardenas). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. EDAT- 2026/07/08 01:10 MHDA- 2026/07/08 01:11 PMCR- 2026/07/07 CRDT- 2026/07/07 13:43 PHST- 2025/12/18 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/07/08 01:11 [medline] PHST- 2026/07/08 01:10 [pubmed] PHST- 2026/07/07 13:43 [entrez] PHST- 2026/07/07 00:00 [pmc-release] AID - PONE-D-25-67135 [pii] AID - 10.1371/journal.pone.0352779 [doi] PST - epublish SO - PLoS One. 2026 Jul 7;21(7):e0352779. doi: 10.1371/journal.pone.0352779. eCollection 2026. PMID- 42412396 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 1440-172X (Electronic) IS - 1322-7114 (Print) IS - 1322-7114 (Linking) VI - 32 IP - 4 DP - 2026 Aug TI - Validity of the Translated Turkish Version of the Tool for Nutrition Risk Screening for Paediatric Cancer. PG - e70168 LID - 10.1111/ijn.70168 [doi] LID - e70168 AB - BACKGROUND: Malnutrition in paediatric cancer patients increases adverse clinical outcomes; however, methods for assessing malnutrition risk remain unclear. This study aimed to assess the validity of the Nutrition Risk Screening for Pediatric Cancer (NRS-PC). METHODS: This cross-sectional study was conducted in the paediatric oncology unit of a tertiary care university hospital. The nutritional risk and malnutrition status were assessed by the Nutrition Screening Tool for Childhood Cancer (SCAN) and Pediatric Subjective Global Nutritional Assessment (SGNA), respectively. Receiver-operator characteristic (ROC) curve method was used to evaluate the validity of NRS-PC. Sensitivity, specificity, positive and negative predictive values were calculated. RESULTS: The median age of children was 8 years, and 60.2% were boys. The prevalence of malnutrition was 48.4%. NRS-PC had excellent accuracy compared with SCAN (AUC: 0.87, 95% CI: 0.827-0.944; p < 0.001) and SGNA (AUC: 0.90, 95% CI: 0.847-0.951; p < 0.001). Using SGNA as a reference method, the NRS-PC tool had a sensitivity of 77.4%-100% and specificity of 24.2%-86.4% according to different cut-off points. CONCLUSION: The Turkish version of the NRS-PC is a simple, valid and practical method for nutritional risk screening in the paediatric oncology population. Further feasibility and acceptability studies are needed to determine the most appropriate screening tools in children. CI - (c) 2026 The Author(s). International Journal of Nursing Practice published by John Wiley & Sons Australia, Ltd. FAU - Meral, Buket AU - Meral B AUID- ORCID: 0000-0003-1664-9333 AD - Department of Child Health and Diseases Nursing, Faculty of Health Sciences, Karadeniz Technical University, Trabzon, Turkey. FAU - Kangalgil, Melda AU - Kangalgil M AUID- ORCID: 0000-0003-2868-8903 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Sivas Cumhuriyet University, Sivas, Turkey. FAU - Erduran, Erol AU - Erduran E AD - Department of Pediatric Hematology and Oncology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey. LA - eng PT - Journal Article PT - Validation Study PL - Australia TA - Int J Nurs Pract JT - International journal of nursing practice JID - 9613615 SB - IM MH - Humans MH - Turkey MH - Male MH - Child MH - Cross-Sectional Studies MH - Female MH - *Nutrition Assessment MH - *Neoplasms/complications MH - *Malnutrition/diagnosis MH - Child, Preschool MH - Risk Assessment MH - Nutritional Status PMC - PMC13340497 OTO - NOTNLM OT - malnutrition OT - nurses OT - nursing OT - nutritional assessment OT - paediatric oncology OT - sensitivity OT - specificity COIS- The authors declare no conflicts of interest. EDAT- 2026/07/07 12:34 MHDA- 2026/07/07 18:54 PMCR- 2026/07/07 CRDT- 2026/07/07 11:26 PHST- 2026/06/01 00:00 [revised] PHST- 2025/03/11 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/07/07 18:54 [medline] PHST- 2026/07/07 12:34 [pubmed] PHST- 2026/07/07 11:26 [entrez] PHST- 2026/07/07 00:00 [pmc-release] AID - IJN70168 [pii] AID - 10.1111/ijn.70168 [doi] PST - ppublish SO - Int J Nurs Pract. 2026 Aug;32(4):e70168. doi: 10.1111/ijn.70168. PMID- 42410484 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260930 LR - 20261002 IS - 2055-0928 (Electronic) IS - 2055-0928 (Linking) VI - 12 IP - 1 DP - 2026 Jul 6 TI - Misreporting of energy intake estimated by food records among adolescents in Lao People's Democratic Republic: a cross-sectional study. LID - 10.1186/s40795-026-01416-y [doi] LID - 203 AB - BACKGROUND: Accurate dietary assessment data is vital for understanding dietary patterns and the associated nutrition and health outcomes. However, research on misreporting from self-reported dietary assessment tools has remained limited in low- and middle-income countries. Our study aims to investigate energy intake misreporting and its determinants among adolescents in Lao People's Democratic Republic (PDR). METHODS: We conducted a cross-sectional secondary analysis of seven-day estimated food records collected from 405 adolescents aged 10-18 years attending secondary schools in Vientiane Province, Lao PDR, between March and April 2019. We identified energy intake misreporting using the Goldberg cut-off method, and analyzed factors associated with energy intake underreporting using multivariable logistic regression analyses. We compared the percentage energy intake from each food group between plausible reporters and underreporters, using the Mann-Whitney U-test. RESULTS: Approximately 61.2% of participants underreported and 0.3% overreported their energy intake. Older adolescents (15-18 years) were 50% less likely to be classified as underreporters than younger adolescents (10-14 years) (Adjusted Odds Ratio [AOR] = 0.54, 95% CI: 0.34-0.88). Higher Body Mass Index was associated with higher odds of underreporting (AOR = 1.09, 95% CI: 1.01-1.18), whereas higher number of reported snacks between meals was associated with lower odds of underreporting (AOR = 0.81, 95% CI: 0.76-0.86). Underreporting increased over the seven-day period (51.4% on day 1 to 65.9% on day 7). CONCLUSIONS: This study highlights a high prevalence of energy intake underreporting among Lao PDR adolescents when using the seven-day estimated food record method. While this prospective method has advantages, its accuracy depends on sustained participant engagement and motivation. Future research is needed to develop, adapt and validate tools, such as technology-assisted tools, for use among adolescents in Lao PDR. CI - (c) 2026. The Author(s). FAU - Kounnavong, Thidatheb AU - Kounnavong T AUID- ORCID: 0009-0007-5614-6147 AD - School of Tropical Medicine and Global Health, Nagasaki University, 1 Chome-12-4 Sakamoto, Nagasaki, 852-8102, Japan. thidatheb.kounnavong@nagasaki-u.ac.jp. FAU - Moji, Kazuhiko AU - Moji K AD - School of Tropical Medicine and Global Health, Nagasaki University, 1 Chome-12-4 Sakamoto, Nagasaki, 852-8102, Japan. moji.k273@gmail.com. FAU - Sato, Miho AU - Sato M AD - School of Tropical Medicine and Global Health, Nagasaki University, 1 Chome-12-4 Sakamoto, Nagasaki, 852-8102, Japan. FAU - Turner, Christopher AU - Turner C AD - Food and Markets Department, Natural Resources Institute, University of Greenwich, London, UK. FAU - Vonglokham, Manithong AU - Vonglokham M AD - Department of Health Policy and Health System Research, Lao Tropical and Public Health Institute, Vientiane, Lao People's Democratic Republic. FAU - Ferguson, Elaine AU - Ferguson E AD - Department of Population Health, London School of Hygiene and Tropical Medicine, London, UK. LA - eng PT - Journal Article DEP - 20260706 PL - England TA - BMC Nutr JT - BMC nutrition JID - 101672434 PMC - PMC13625445 OTO - NOTNLM OT - Adolescent OT - Cross sectional study OT - Dietary assessment OT - Energy intake OT - Food Record OT - Lao People's Democratic Republic OT - Misreporting OT - Technologies OT - Underreporting COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the principles of the Declaration of Helsinki. The study utilized secondary data collected as part of a separate project conducted by the Lao Tropical and Public Health Institute, which received ethical approval from the National Ethical Committee for Health Research of Lao PDR (Protocol No. 013/2019/NECHR). Informed consent was obtained from all adolescent participants and their legal guardians before the data were collected. The study strictly followed the relevant guidelines and regulations. The dataset is fully anonymized and de-identified, ensuring that no individual participants could be identified or traced. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/07 00:38 MHDA- 2026/07/07 00:39 PMCR- 2026/07/06 CRDT- 2026/07/07 00:00 PHST- 2026/03/18 00:00 [received] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/07/07 00:39 [medline] PHST- 2026/07/07 00:38 [pubmed] PHST- 2026/07/07 00:00 [entrez] PHST- 2026/07/06 00:00 [pmc-release] AID - 10.1186/s40795-026-01416-y [pii] AID - 1416 [pii] AID - 10.1186/s40795-026-01416-y [doi] PST - epublish SO - BMC Nutr. 2026 Jul 6;12(1):203. doi: 10.1186/s40795-026-01416-y. PMID- 42409932 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20261001 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jul 6 TI - Normalization of muscle strength measures in barbell exercises by sex, age, and anthropometry: notes on allometry. LID - 10.1038/s41598-026-60646-z [doi] LID - 20797 AB - Accurate strength assessment requires consideration of individual anthropometric and demographic differences. Traditional absolute and body mass-normalized measures often fail to capture inter-individual variability, thereby limiting the precision of strength testing and classification. This study aimed to investigate the influence of age, body mass, height, and anthropometric characteristics on strength capacity and to systematically integrate these variables into a classification framework. A total of 393 individuals (197 females, 196 males), aged 16-64 years and ranging from beginners to elite powerlifters, were recruited. One-repetition maximum (1-RM) strength was assessed in the bench press (BP), back squat (SQ), and deadlift (DL). Age, height, body mass, and selected anthropometric variables including arm and leg lengths, were recorded. Multiple regression analyses were used to quantify the influence of these variables on 1-RM performance. Based on significant predictors, individualized z-scores were computed to standardize 1-RM values relative to relevant anthropometric and demographic factors. The applicability of these z-scores to interval-based classification frameworks was evaluated. Age, body mass, and height were identified as significant determinants of maximal strength across all 3 exercises. Incorporation of these variables into z-score calculation enabled a more precise and individualized assessment of strength performance. Attempts to apply z-scores to interval-based classification frameworks revealed substantial within-category heterogeneity, indicating that such frameworks are unsuitable for accurate strength classification. This study establishes an anthropometry- and demography-adjusted framework for strength assessment in BP, SQ, and DL among healthy adults aged 16-64 years. Standardized z-scores provide a biologically meaningful alternative to conventional normalization methods. The proposed z-score framework provides a reproducible, data-driven tool for individualized strength assessment in the BP, SQ and DL, with direct applications in sport science research, performance monitoring, and strength-based rehabilitation for healthy adults aged 16-64 years. CI - (c) 2026. The Author(s). FAU - Isenmann, Eduard AU - Isenmann E AUID- ORCID: 0000-0003-3300-5118 AD - Department of Fitness and Health, IST University of Applied Sciences, Duesseldorf, Germany. eisenmann@ist-hochschule.de. AD - Department of Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germany. eisenmann@ist-hochschule.de. FAU - Geisler, Stephan AU - Geisler S AD - Department of Fitness and Health, IST University of Applied Sciences, Duesseldorf, Germany. FAU - Havers, Tim AU - Havers T AD - Department of Fitness and Health, IST University of Applied Sciences, Duesseldorf, Germany. AD - Exercise Biology Group, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Gavanda, Simon AU - Gavanda S AD - Department of Fitness and Health, IST University of Applied Sciences, Duesseldorf, Germany. FAU - Diel, Patrick AU - Diel P AD - Department of Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germany. FAU - Held, Steffen AU - Held S AD - Department of Sport and Management, IST University of Applied Sciences, Duesseldorf, Germany. FAU - Flenker, Ulrich AU - Flenker U AD - Department of Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germany. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260706 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Female MH - Adult MH - *Muscle Strength/physiology MH - Humans MH - Adolescent MH - Middle Aged MH - Male MH - Young Adult MH - *Anthropometry MH - Age Factors MH - *Weight Lifting/physiology MH - Sex Factors MH - *Exercise/physiology PMC - PMC13338387 OTO - NOTNLM OT - Allometric scaling OT - Framework OT - Maximal strength OT - Performance OT - Strength classification COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/07/07 00:39 MHDA- 2026/07/07 19:11 PMCR- 2026/07/06 CRDT- 2026/07/06 23:27 PHST- 2026/02/10 00:00 [received] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/07/07 19:11 [medline] PHST- 2026/07/07 00:39 [pubmed] PHST- 2026/07/06 23:27 [entrez] PHST- 2026/07/06 00:00 [pmc-release] AID - 10.1038/s41598-026-60646-z [pii] AID - 60646 [pii] AID - 10.1038/s41598-026-60646-z [doi] PST - epublish SO - Sci Rep. 2026 Jul 6;16(1):20797. doi: 10.1038/s41598-026-60646-z. PMID- 42404934 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Physical activity awareness and its relationship with motivation among college students: development and validation of a Multidimensional Scale. PG - 1856461 LID - 10.3389/fpubh.2026.1856461 [doi] LID - 1856461 AB - INTRODUCTION: Physical activity (PA) levels remain insufficient among young adults, particularly college students, whose behavioral patterns often persist into adulthood. Although psychological factors are recognized as important determinants of PA behavior, limited attention has been paid to how individuals perceive and interpret their own physical activity and surrounding context. This study aimed to develop and validate a multidimensional scale measuring college students' perceived PA awareness. METHODS: A sequential mixed-method design was employed. In the qualitative phase, focus group interviews were conducted to explore college students' understanding of PA awareness. Based on thematic analysis, four dimensions were identified: personal PA awareness, social support awareness, environmental awareness, and PA recommendation awareness. An initial item pool was then developed and administered to 994 undergraduate students from eight universities. Confirmatory factor analysis (CFA) was conducted to examine the factorial validity of the scale, and internal consistency reliability was assessed using Cronbach's alpha coefficients. RESULTS: CFA supported a stable four-factor structure with acceptable model fit indices (RMSEA = 0.046, SRMR = 0.035, CFI = 0.968). The subscales demonstrated satisfactory internal consistency, with Cronbach's ? values ranging from 0.741 to 0.919. These findings provide empirical support for the reliability and construct validity of the proposed scale. DISCUSSION: The findings suggest that PA awareness is a multidimensional psychological construct reflecting both individual perceptions and contextual influences. The developed scale may contribute to a better understanding of motivational processes underlying physical activity engagement among college students and provide a structured framework for future research on psychological determinants of PA behavior. CI - Copyright (c) 2026 Shangguan, Xie and Hamilton. FAU - Shangguan, Rulan AU - Shangguan R AD - School of Physical Education, South China University of Technology, Guangzhou, China. FAU - Xie, Jiajing AU - Xie J AD - School of Physical Education, South China University of Technology, Guangzhou, China. FAU - Hamilton, Xiaofen AU - Hamilton X AD - Department of Curriculum and Instruction, College of Education, The University of Texas at Austin, Austin, TX, United States. LA - eng PT - Journal Article PT - Validation Study DEP - 20260619 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Students/psychology/statistics & numerical data MH - Universities MH - Female MH - *Motivation MH - *Exercise/psychology MH - Young Adult MH - Reproducibility of Results MH - Male MH - Focus Groups MH - *Awareness MH - Psychometrics MH - Factor Analysis, Statistical MH - Surveys and Questionnaires/standards MH - Adolescent MH - Qualitative Research MH - Adult MH - *Health Knowledge, Attitudes, Practice PMC - PMC13328250 OTO - NOTNLM OT - college students OT - health behavior OT - mixed methods OT - physical activity awareness OT - psychometric validation OT - scale development COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/06 10:10 MHDA- 2026/07/06 12:41 PMCR- 2026/06/19 CRDT- 2026/07/06 05:40 PHST- 2026/04/15 00:00 [received] PHST- 2026/05/07 00:00 [revised] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/07/06 12:41 [medline] PHST- 2026/07/06 10:10 [pubmed] PHST- 2026/07/06 05:40 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1856461 [doi] PST - epublish SO - Front Public Health. 2026 Jun 19;14:1856461. doi: 10.3389/fpubh.2026.1856461. eCollection 2026. PMID- 42403893 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260706 LR - 20260813 IS - 1178-6965 (Print) IS - 1178-6965 (Electronic) IS - 1178-6965 (Linking) VI - 19 DP - 2026 TI - Skeletal Muscle Mass and Visceral Fat are Independently Associated with Poorly Controlled Asthma in Children with Obesity: A Cross-Sectional Study. PG - 600914 LID - 10.2147/JAA.S600914 [doi] LID - 600914 AB - PURPOSE: The role of body composition-particularly skeletal muscle mass and visceral fat-in asthma control among children with obesity remains unclear. We compared body composition between children with obesity with and without asthma and examined associations with asthma control. PATIENTS AND METHODS: We enrolled 191 children with obesity aged 6-14 years (85 with asthma, 106 without). Skeletal muscle mass (SMM)-to-body weight (WT) ratio and visceral fat area (VFA) were measured by multi-frequency bioelectrical impedance analysis. Poorly controlled asthma was defined using validated cut-points: Childhood Asthma Control Test /=12). Variables were screened by least absolute shrinkage and selection operator logistic regression; the model was assessed by receiver operating characteristic curve, calibration, and decision-curve analyses. RESULTS: The obese-asthma group had lower SMM/WT than the simple-obesity group (30.17% vs 31.51%, P<0.001); VFA did not differ significantly (P=0.051). Among children with obese-asthma, the poorly controlled group showed lower SMM/WT (P=0.002) and higher VFA (P=0.011). In multivariable analysis, SMM/WT (OR=0.664 per 1%, 95% CI 0.497-0.889, P=0.006), VFA (OR=1.014 per 1 cm(2), 95% CI 1.001-1.028, P=0.034), maximal mid-expiratory flow (MMEF) percent predicted (OR=1.073, 95% CI 1.007-1.143, P=0.029), and extracellular water to total body water ratio (ECW/TBW) (OR=1.719 per 0.01, 95% CI 1.000-2.956, P=0.050) were independently associated with poorly controlled asthma. The area under the curve (AUC) was 0.807 (95% CI 0.709-0.905; sensitivity 76.9%, specificity 75.8%; mean absolute error 0.027). CONCLUSION: Lower SMM/WT, higher VFA, higher MMEF percent predicted, and higher ECW/TBW were independently associated with poorly controlled asthma in children with obesity. The four-variable model showed good discrimination (AUC=0.807). These exploratory associations require prospective validation before clinical application. CI - (c) 2026 Wang et al. FAU - Wang, Zhiyuan AU - Wang Z AUID- ORCID: 0000-0001-7990-9740 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China. FAU - Zhao, Junlin AU - Zhao J AUID- ORCID: 0009-0002-9080-9622 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China. FAU - Wang, Yanan AU - Wang Y AUID- ORCID: 0009-0008-3176-160X AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China. FAU - Dai, Qianqian AU - Dai Q AUID- ORCID: 0009-0005-7647-0812 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China. FAU - Qu, Shengmeng AU - Qu S AUID- ORCID: 0009-0004-2746-3408 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China. FAU - Ru, Liang AU - Ru L AUID- ORCID: 0009-0002-2200-3889 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China. LA - eng PT - Journal Article DEP - 20260629 PL - New Zealand TA - J Asthma Allergy JT - Journal of asthma and allergy JID - 101543450 PMC - PMC13332121 OAB - WHY DID WE DO THIS STUDY? Obesity and asthma are both becoming more common in children. Children who have both conditions may have less well-controlled asthma. Doctors usually record only height and weight, which do not show how much muscle a child has or where body fat is stored. We wanted to learn whether measuring muscle and fat separately could help explain why some children with obesity have poorer asthma control. WHAT DID WE DO? We studied 191 children with obesity aged 6-14 years. We used a body-composition scanner to estimate muscle mass and visceral fat (the fat stored around internal organs). We compared children with and without asthma, and-among those with asthma-children whose symptoms were poorly controlled with the rest of the asthma group, who had comparatively better symptom control. WHAT DID WE FIND? Children with obesity and asthma had less muscle relative to their body weight than children with obesity alone. Among the children with asthma, those whose asthma was poorly controlled tended to have lower muscle mass and higher visceral fat. Using these measures, we built a preliminary tool to help estimate which children might be at higher risk of poor asthma control. WHAT DOES THIS MEAN? Looking at body composition, rather than weight alone, may give doctors additional information about asthma in children with obesity, and could support more individualized care in the future. Further studies in other groups of children are needed before these measures can be used in routine practice. OABL- eng OTO - NOTNLM OT - asthma OT - pediatric obesity OT - sarcopenic obesity OT - skeletal muscle mass OT - visceral fat COIS- The authors declare no competing interests in this work. EDAT- 2026/07/06 10:10 MHDA- 2026/07/06 10:11 PMCR- 2026/06/29 CRDT- 2026/07/06 05:28 PHST- 2026/02/03 00:00 [received] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/07/06 10:11 [medline] PHST- 2026/07/06 10:10 [pubmed] PHST- 2026/07/06 05:28 [entrez] PHST- 2026/06/29 00:00 [pmc-release] AID - 600914 [pii] AID - 10.2147/JAA.S600914 [doi] PST - epublish SO - J Asthma Allergy. 2026 Jun 29;19:600914. doi: 10.2147/JAA.S600914. eCollection 2026. PMID- 42403888 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260706 LR - 20260813 IS - 1178-6965 (Print) IS - 1178-6965 (Electronic) IS - 1178-6965 (Linking) VI - 19 DP - 2026 TI - A Clinical Nomogram for Predicting Early Response to Biologics in Pediatric Allergic Asthma with Comorbid Allergic Rhinitis. PG - 604654 LID - 10.2147/JAA.S604654 [doi] LID - 604654 AB - BACKGROUND: The coexistence of allergic rhinitis (AR) and allergic asthma poses a significant burden on pediatric health. While biologics targeting type 2 inflammation have revolutionized treatment, individual responses vary significantly. There is a lack of practical tools to predict early therapeutic response before initiation. This study aimed to identify key baseline predictors and construct a nomogram to personalize the prediction of early response to biologics in children with AR and allergic asthma. METHODS: This retrospective cohort study included 246 children (recruited between January 2021 and August 2025) diagnosed with moderate-to-severe allergic AR and allergic asthma who received biologic therapy (Omalizumab or Dupilumab). Early response was assessed at 16 weeks based on a composite outcome involving the Asthma Control Test (ACT), visual analog scale (VAS) for nasal symptoms, and exacerbation history. Independent predictors were identified using LASSO regression and multivariate logistic regression analysis to build a nomogram. The model's performance was evaluated using the concordance index (C-index), calibration curves, and decision curve analysis (DCA). RESULTS: Of the 246 patients, 164 (66.7%) were classified as early responders. Multivariate analysis identified baseline fractional exhaled nitric oxide (FeNO), blood eosinophil count (EOS), total IgE levels, comorbidity of atopic dermatitis (AD), and Body Mass Index (BMI) as independent predictors. The developed nomogram demonstrated good discrimination with a C-index of 0.88 (95% CI: 0.83-0.93) in the training cohort and 0.85 (95% CI: 0.78-0.92) in the validation cohort. Calibration curves showed excellent agreement between predicted and observed probabilities. DCA indicated significant clinical net benefit across a wide range of threshold probabilities. CONCLUSION: We successfully developed a novel nomogram incorporating baseline type 2 inflammatory endotypes and AD comorbidity to predict early response to biologics in pediatric patients with allergic asthma and comorbid AR. This tool offers clinicians a practical method to screen potential "super-responders", thereby optimizing therapeutic decision-making and resource allocation. CI - (c) 2026 Wang et al. FAU - Wang, Lixin AU - Wang L AD - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, People's Republic of China. FAU - Kang, Zhaopeng AU - Kang Z AD - Health Management Center, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, People's Republic of China. FAU - Ma, Jun AU - Ma J AD - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, People's Republic of China. FAU - Wang, Chuanxi AU - Wang C AD - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, People's Republic of China. FAU - Jiang, Wanjin AU - Jiang W AD - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, People's Republic of China. FAU - Huang, Jingjiang AU - Huang J AD - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, People's Republic of China. FAU - Liu, Shaofeng AU - Liu S AD - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, People's Republic of China. LA - eng PT - Journal Article DEP - 20260630 PL - New Zealand TA - J Asthma Allergy JT - Journal of asthma and allergy JID - 101543450 PMC - PMC13332785 OTO - NOTNLM OT - allergic asthma OT - allergic rhinitis OT - biological therapy OT - nomogram OT - pediatrics OT - type 2 inflammation COIS- Lixin Wang and Zhaopeng Kang are co-first authors for this study. The authors declare that they have no competing interests for this work. EDAT- 2026/07/06 10:10 MHDA- 2026/07/06 10:11 PMCR- 2026/06/30 CRDT- 2026/07/06 05:28 PHST- 2026/03/02 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/07/06 10:11 [medline] PHST- 2026/07/06 10:10 [pubmed] PHST- 2026/07/06 05:28 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - 604654 [pii] AID - 10.2147/JAA.S604654 [doi] PST - epublish SO - J Asthma Allergy. 2026 Jun 30;19:604654. doi: 10.2147/JAA.S604654. eCollection 2026. PMID- 42402421 OWN - NLM STAT- MEDLINE DCOM- 20260705 LR - 20260813 IS - 1365-2214 (Electronic) IS - 0305-1862 (Print) IS - 0305-1862 (Linking) VI - 52 IP - 4 DP - 2026 Jul TI - Translation and Cross-Cultural Adaptation of the Family Nutrition and Physical Activity Screening Tool for Portuguese Well-Child Visits. PG - e70316 LID - 10.1111/cch.70316 [doi] LID - e70316 AB - BACKGROUND: Family environments play a critical role in shaping children's lifestyle behaviours that influence obesity risk. However, culturally validated instruments to assess these behaviours are lacking in Portuguese primary care. AIM: This study aims to translate and culturally adapt the Family Nutrition and Physical Activity (FNPA) screening tool for use in Portugal (FNPA-PT) and to evaluate its face and content validity through cognitive interviews with parents attending well-child visits. DESIGN AND METHODS: An exploratory, descriptive study followed internationally endorsed guidelines (Beaton; MAPI) for translation and cross-cultural adaptation. The process comprised seven stages: forward translations, synthesis, back translations, comparisons of back translations, expert committee review, cognitive debriefing and final proofreading. Ten parents of five-year-old children attending a public primary care centre in Lisbon completed the FNPA-PT while participating in individual cognitive interviews. Data were analysed using Content Analysis, guided by Tourangeau's four-stage response model. RESULTS: Semantic equivalence between forward and back translations was high (85% of items with satisfactory or perfect equivalence). Minor linguistic and cultural adaptations were introduced to improve clarity and contextual relevance. Cognitive interviews indicated that the FNPA-PT was well understood, acceptable to parents, and feasible to complete during well-child visits. Parents valued the questionnaire's comprehensiveness and its potential to enhance awareness and stimulate discussion about family health behaviours. Minor revisions addressed comprehension issues in three items related to milk consumption, screen time and sleep. CONCLUSIONS: The FNPA-PT demonstrated strong face and content validity and high acceptability among Portuguese parents. It provides a culturally appropriate, family-centred tool for health professionals to support early identification of obesogenic environments and to guide preventive counselling in primary care. The study also offers a transparent methodological pathway for translating and adapting behavioural measures across languages and settings. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Rodrigues, Sonia Borges AU - Rodrigues SB AUID- ORCID: 0000-0002-9453-4876 AD - Nursing Research, Innovation and Development Centre of Lisbon (CIDNUR), School of Nursing, Universidade de Lisboa, Lisbon, Portugal. AD - Department of Child and Adolescent Nursing, School of Nursing, Universidade de Lisboa, Lisbon, Portugal. FAU - Rodrigues, Ricardo Borges AU - Rodrigues RB AUID- ORCID: 0000-0002-6720-2905 AD - Department of Psychology, Instituto Universitario de Lisboa (Iscte-IUL), Lisbon, Portugal. AD - Centro de Investigacao e Intervencao Social (CIS-Iscte), Lisbon, Portugal. FAU - Saboga-Nunes, Luis AU - Saboga-Nunes L AD - Department of Public Health, Institute of Sociology, University of Education Freiburg, Freiburg, Germany. AD - UNESCO Chair and WHO Collaborating Center in Global Health & Education, Paris, France. FAU - Barros, Luisa AU - Barros L AD - Faculty of Psychology, University of Lisbon, Lisbon, Portugal. AD - CICPsi, Center for Research in Psychological Science, University of Lisbon, Lisbon, Portugal. FAU - Salantera, Sanna AU - Salantera S AUID- ORCID: 0000-0003-2529-6699 AD - Department of Nursing Science, Faculty of Medicine, University of Turku, Turku, Finland. AD - Turku University Hospital, Turku, Finland. LA - eng PT - Journal Article PL - England TA - Child Care Health Dev JT - Child: care, health and development JID - 7602632 SB - IM MH - Humans MH - Portugal/epidemiology MH - Child, Preschool MH - Male MH - Female MH - Translations MH - Cross-Cultural Comparison MH - Surveys and Questionnaires MH - Reproducibility of Results MH - *Exercise MH - Primary Health Care MH - Parents/psychology MH - *Pediatric Obesity/prevention & control PMC - PMC13382483 OTO - NOTNLM OT - cognitive interviews OT - cultural adaptation OT - family nutrition and physical activity (FNPA) OT - paediatric obesity OT - patient-reported outcome measures OT - primary health care OT - well-child visits COIS- The authors declare no conflicts of interest. EDAT- 2026/07/06 04:10 MHDA- 2026/07/06 04:11 PMCR- 2026/07/20 CRDT- 2026/07/05 21:42 PHST- 2026/05/29 00:00 [revised] PHST- 2025/11/07 00:00 [received] PHST- 2026/06/13 00:00 [accepted] PHST- 2026/07/06 04:11 [medline] PHST- 2026/07/06 04:10 [pubmed] PHST- 2026/07/05 21:42 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - CCH70316 [pii] AID - 10.1111/cch.70316 [doi] PST - ppublish SO - Child Care Health Dev. 2026 Jul;52(4):e70316. doi: 10.1111/cch.70316. PMID- 42401849 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260929 IS - 1471-2377 (Electronic) IS - 1471-2377 (Linking) VI - 26 IP - 1 DP - 2026 Jul 4 TI - Screen time patterns and cognitive screening outcomes (MoCA-Ina) in adolescents: a cross-sectional study. LID - 10.1186/s12883-026-05128-5 [doi] LID - 609 AB - BACKGROUND: Adolescent screen exposure is increasing, yet clinically interpretable thresholds for cognitive risk are unclear. This study examined associations between daily screen time and cognitive screening performance and derived a screen-time cutoff associated with cognitive impairment. METHODS: We conducted an observational cross-sectional study (March-April 2022) at a private junior high school in Indonesia during online learning. Students completed digital questionnaires reporting educational and recreational screen time and a directly reported overall estimate; a computed overall (educational + recreational) was generated to assess reporting consistency. Cognitive function was assessed using the MoCA-Ina, with < 24 as the primary impairment threshold based on recent psychometric evidence favoring lower cutoffs for improved classification accuracy. RESULTS: Sixty-seven adolescents were included (34 girls, 50.7%; 33 boys, 49.3%), with median age 13.0 years (12.0-16.0) and median MoCA-Ina 25.0 (19.0-31.0). MoCA-Ina did not differ by sex (girls 25.0 [19.0-31.0] vs. boys 26.0 [20.0-30.0]; p = 0.244). Recreational screen time correlated inversely with MoCA-Ina (rho = -0.446, p < 0.001), as did overall screen time (rho = -0.360, p = 0.003), whereas educational screen time was not associated (rho = -0.061, p = 0.624). In adjusted regression, overall screen time remained negatively associated with MoCA-Ina (beta = -0.24 per hour/day; 95% CI - 0.41 to - 0.07; p = 0.007), while age was positively associated (beta = 0.96; 95% CI 0.07 to 1.85; p = 0.034). All variance inflation factors were below 2.5, indicating no substantial multicollinearity. ROC analysis showed fair discrimination (AUC 0.66; optimism-corrected AUC after bootstrap internal validation [1,000 resamples]: 0.63) with an optimal cutoff > 8.97 h/day (sensitivity 83.3%, specificity 48.8%, PPV 47.6%, NPV 84.0%); risk of impairment was higher above the cutoff (RR 2.98; 95% CI 1.15-7.72; p = 0.010; OR 4.77; 95% CI 1.40-16.31). CONCLUSIONS: High daily screen exposure was associated with poorer cognitive screening performance. The > 8.97-hour/day threshold represents a preliminary, hypothesis-generating cutoff that may help identify adolescents at elevated likelihood of cognitive impairment, pending external validation in larger, more diverse samples. TRIAL REGISTRATION: 071/K-LKJ/ETIK/II/2022. CI - (c) 2026. The Author(s). FAU - Gunawan, Pricilla Yani AU - Gunawan PY AUID- ORCID: 0000-0002-5620-3267 AD - Department of Neurology, Faculty of Medicine, Universitas Pelita Harapan, Jl. Jenderal Sudirman No.15, Tangerang, Banten, 15810, Indonesia. pricilla.yani@outlook.com. AD - Department of Neurology, Siloam Hospitals Lippo Village, Tangerang, Indonesia. pricilla.yani@outlook.com. FAU - Andraina, Andraina AU - Andraina A AD - Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Banten, Indonesia. FAU - Wijaya, Jeremiah Hilkiah AU - Wijaya JH AD - School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia. FAU - Arjuna, Yang Yang Endro AU - Arjuna YYE AUID- ORCID: 0000-0002-5916-1453 AD - Department of Neurology, Siloam Hospitals Lippo Village, Tangerang, Indonesia. AD - Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Banten, Indonesia. FAU - Gunawan, Patricia Yulita AU - Gunawan PY AUID- ORCID: 0000-0002-3287-0671 AD - Department of Paediatrics, Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Banten, Indonesia. AD - Department of Paediatrics, University of Oxford, Oxford, UK. LA - eng PT - Journal Article PT - Observational Study DEP - 20260704 PL - England TA - BMC Neurol JT - BMC neurology JID - 100968555 SB - IM MH - Humans MH - Male MH - Cross-Sectional Studies MH - *Screen Time MH - Adolescent MH - Female MH - Child MH - *Cognitive Dysfunction/diagnosis/psychology MH - *Cognition MH - Media Exposure MH - Surveys and Questionnaires MH - Neuropsychological Tests MH - Indonesia PMC - PMC13613649 OTO - NOTNLM OT - Adolescent OT - Cognition OT - ROC curve OT - Screen time COIS- Declarations. Ethics approval and consent to participate: This observational cross-sectional study was reviewed and approved by the institutional ethics committee of the Faculty of Medicine, Pelita Harapan University (Approval No.: 071/K-LKJ/ETIK/II/2022). The study was conducted in accordance with the Declaration of Helsinki and applicable local regulations. Written informed consent to participate was obtained from all participants. For any participant under the age of 16 years, written informed consent was obtained from their parent or legal guardian prior to participation. Informed consent was obtained from all individual participants included in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/05 00:37 MHDA- 2026/09/25 05:31 PMCR- 2026/07/04 CRDT- 2026/07/04 23:34 PHST- 2026/02/10 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/09/25 05:31 [medline] PHST- 2026/07/05 00:37 [pubmed] PHST- 2026/07/04 23:34 [entrez] PHST- 2026/07/04 00:00 [pmc-release] AID - 10.1186/s12883-026-05128-5 [pii] AID - 5128 [pii] AID - 10.1186/s12883-026-05128-5 [doi] PST - epublish SO - BMC Neurol. 2026 Jul 4;26(1):609. doi: 10.1186/s12883-026-05128-5. PMID- 42401398 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260807 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 226 DP - 2026 Nov 1 TI - Gratitude for food as a driver of improved dietary behaviors: A scoping review. PG - 108703 LID - S0195-6663(26)00265-5 [pii] LID - 10.1016/j.appet.2026.108703 [doi] AB - Gratitude for food (GF) is a positive emotional response linked to healthier dietary behaviors, mindful eating, and food waste reduction. Despite increasing research interest internationally and in Japan, existing research has not been systematically integrated, and measurement tools remain fragmented. This study aims to systematically map and synthesize international and Japanese studies on GF, clarify current knowledge, detail the characteristics and thematic focuses of existing research, critically examine the variety and validation status of GF measurement tools, and identify the cultural and methodological gaps within the literature. A scoping review following PRISMA-ScR guidelines was conducted. Searches of five databases-SCOPUS, PubMed, EBSCO host, Ichushi-web, and J-stage-in English and Japanese were conducted covering publications from 1995 to 2025. Data extraction included study characteristics, GF measurement tools, and intervention details. Quantitative text mining analyzed the research themes. Thirty-nine studies were included, encompassing cross-sectional, intervention, qualitative, mixed-methods, and scale development designs. Five research focus clusters emerged: school lunches, nutrition education programs, food waste, mindful eating, and scale development. Five validated GF scales were identified, some with cross-cultural adaptations, but their use and validation were fragmented. Intervention studies were predominantly non-randomized controlled trials in Japan, focusing on school-aged children, with mixed evidence on effectiveness. GF is a culturally nuanced construct with important implications for promoting healthier dietary habits, reducing food waste, and fostering mindful eating. Future research should focus on harmonizing measurement tools and conducting rigorous intervention studies to advance the field. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Kawasaki, Yui AU - Kawasaki Y AD - Institute for SDGs Promotion, Organization for Social Implementation of Sustainability, Ochanomizu University, 2-1-1 Otsuka Bunkyo-ku, Tokyo, 112-8610, Japan. Electronic address: kawasaki.yui@ocha.ac.jp. FAU - Nagao-Sato, Sayaka AU - Nagao-Sato S AD - Graduate School of Public Health, Shizuoka Graduate University of Public Health, 4-27-2, Kita Ando, Aoi-ku, Shizuoka, 420-0881, Japan. Electronic address: sysato@s-sph.ac.jp. FAU - Yoshii, Emi AU - Yoshii E AD - Department of Food and Health Sciences, Faculty of Health and Human Development, The University of Nagano, Japan. Electronic address: yoshii.emi@u-nagano.ac.jp. FAU - Akamatsu, Rie AU - Akamatsu R AD - Natural Science Division, Faculty of Core Research, Ochanomizu University, 2-1-1 Otsuka Bunkyo-ku, Tokyo, 112-8610, Japan. Electronic address: akamatsu.rie@ocha.ac.jp. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260704 PL - England TA - Appetite JT - Appetite JID - 8006808 RN - 0 (Food Loss and Waste) SB - IM MH - Humans MH - *Feeding Behavior/psychology MH - *Diet, Healthy/psychology MH - Japan MH - Food Loss and Waste MH - Child MH - Mindfulness MH - *Food MH - Emotions MH - Health Behavior OTO - NOTNLM OT - Dietary behavior OT - Food waste OT - Gratitude OT - Mindful eating OT - Nutrition education COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Yui Kawasaki reports financial support was provided by the Moritani Scholarship Foundation [no grant number]. EDAT- 2026/07/05 00:37 MHDA- 2026/08/08 00:40 CRDT- 2026/07/04 19:34 PHST- 2026/03/01 00:00 [received] PHST- 2026/06/29 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/08/08 00:40 [medline] PHST- 2026/07/05 00:37 [pubmed] PHST- 2026/07/04 19:34 [entrez] AID - S0195-6663(26)00265-5 [pii] AID - 10.1016/j.appet.2026.108703 [doi] PST - ppublish SO - Appetite. 2026 Nov 1;226:108703. doi: 10.1016/j.appet.2026.108703. Epub 2026 Jul 4. PMID- 42399820 OWN - NLM STAT- MEDLINE DCOM- 20261004 LR - 20261007 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 4 TI - Nomogram for predicting 6-month BMIZ changes in children with Crohn's disease: a single-center retrospective study. LID - 10.1186/s12887-026-07258-8 [doi] LID - 936 AB - BACKGROUND: Perianal disease (PD) is an aggressive phenotype in children with Crohn's disease (CD), but its measurable impact on short-term nutritional recovery remains understudied. This study aimed to evaluate the independent effect of PD on the 6-month Body Mass Index Z-score (BMIZ) trajectory and to develop a practical nomogram for early risk stratification in pediatric CD. METHODS: A single-center retrospective cohort of 51 pediatric CD patients (29 with PD and 22 without PD) with at least 6 months of follow-up was enrolled from a tertiary hospital in Fujian, southern China, between July 2017 and March 2025. BMIZ trajectories over time were estimated using linear mixed models (LMM). Predictors of 6-month DeltaBMIZ were screened using univariate regression (P < 0.20), followed by LASSO regression (tenfold cross-validation) to construct a nomogram. Model performance was internally validated using 1000 bootstrap resamples (R(2), MAE, RMSE) and calibration plots. Decision curve analysis (DCA) was performed to evaluate clinical utility for predicting inadequate nutritional recovery (DeltaBMIZ /= 10 events). Multiple logistic regression, adjusted for basic demographic and anthropometric covariates (age and body surface area), was utilized across comprehensive inheritance architectures (additive, dominant, recessive, and co-dominant). For clinical translation hypothesis generation, we applied LASSO-penalized logistic regression (alpha = 1), 10-fold cross-validation to derive parsimonious Pharmacogenetic Risk Scores (PGRS). Model performance was evaluated using the optimism-corrected Area Under the Receiver Operating Characteristic Curve (AUC) via 1000-iteration bootstrap resampling, and calibration was assessed via the Brier score. We observed several complex interactions, notably suggesting an increased risk of severe neutropenia in patients carrying a homozygous variant CYP3A5 rs776746 genotype (nominally significant OR 5.58, p = 0.006) and a potential pleiotropic protective effect from NFATC2 rs6021191 (OR 0.09, p = 0.001). Penalized selection allowed the construction of compact, multi-locus mathematical risk scores that demonstrated promising diagnostic discrimination for Neutropenia (optimism-corrected AUC 0.793, 95% CI 0.72-0.85; Brier score 0.12), while displaying limited to moderate performance for other clinically discriminating toxicities like Infection (AUC 0.650) and Gastrointestinal complications (AUC 0.607). The primary contribution of this study is the prioritization of pharmacogenomic candidate signals rather than the proposal of models ready for clinical intervention. The integration of alternative genotype parameterizations and regularized machine learning highlights pathways for future predictive research. However, given the retrospective nature of the study and inherent risks of internal optimism, these scores serve as biologically informed proof-of-concept models that strictly require robust prospective external validation. CI - Copyright (c) 2026 Gutierrez-Caceres, Alarcon-Concha, Aracena-Farias, Torres, Acuna, Sandoval, Silva, Ormeno, Oyarce, Cerpa and Martinez. FAU - Gutierrez-Caceres, Carolina AU - Gutierrez-Caceres C AD - Laboratory of Advanced Research in Personalized Medicine, Department of Pharmaceutical Sciences and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. AD - Faculty of Pharmacy, University of Concepcion, Concepcion, Chile. FAU - Alarcon-Concha, Claudio AU - Alarcon-Concha C AD - Laboratory of Advanced Research in Personalized Medicine, Department of Pharmaceutical Sciences and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. AD - Laboratory of Chemical Carcinogenesis and Pharmacogenetics (CQF), Department of Basic and Clinical Oncology, Faculty of Medicine, University of Chile, Santiago, Chile. FAU - Aracena-Farias, Javiera AU - Aracena-Farias J AD - Laboratory of Advanced Research in Personalized Medicine, Department of Pharmaceutical Sciences and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. FAU - Torres, Esperanza AU - Torres E AD - Laboratory of Advanced Research in Personalized Medicine, Department of Pharmaceutical Sciences and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. FAU - Acuna, Ivan AU - Acuna I AD - Laboratory of Advanced Research in Personalized Medicine, Department of Pharmaceutical Sciences and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. FAU - Sandoval, Tamara AU - Sandoval T AD - Faculty of Pharmacy, University of Concepcion, Concepcion, Chile. FAU - Silva, Pamela AU - Silva P AD - Hospital de Ninos Roberto del Rio, Santiago, Chile. FAU - Ormeno, Maricruz AU - Ormeno M AD - Hospital Luis Calvo Mackenna, Santiago, Chile. FAU - Oyarce, Veronica AU - Oyarce V AD - Hospital Exequiel Gonzalez Cortes, Santiago, Chile. AD - Centro de Investigacion Clinica Avanzada (CICA) Hospital Exequiel Gonzalez Cortes - Facultad de Medicina Universidad de Chile, Santiago, Chile. FAU - Cerpa, Leslie C AU - Cerpa LC AD - Laboratory of Advanced Research in Personalized Medicine, Department of Pharmaceutical Sciences and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. AD - Laboratory of Chemical Carcinogenesis and Pharmacogenetics (CQF), Department of Basic and Clinical Oncology, Faculty of Medicine, University of Chile, Santiago, Chile. AD - Center for Cancer Prevention and Control (CECAN), Santiago, Chile. AD - Latin American Network for Implementation and Validation of Clinical Pharmacogenomics Guidelines (RELIVAF-CYTED), Santiago, Chile. FAU - Martinez, Matias F AU - Martinez MF AD - Laboratory of Advanced Research in Personalized Medicine, Department of Pharmaceutical Sciences and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. AD - Centro de Investigacion Clinica Avanzada (CICA) Hospital Exequiel Gonzalez Cortes - Facultad de Medicina Universidad de Chile, Santiago, Chile. AD - Latin American Network for Implementation and Validation of Clinical Pharmacogenomics Guidelines (RELIVAF-CYTED), Santiago, Chile. LA - eng PT - Journal Article DEP - 20260616 PL - Switzerland TA - Front Pharmacol JT - Frontiers in pharmacology JID - 101548923 PMC - PMC13314868 OTO - NOTNLM OT - acute lymphoblastic leukemia OT - adverse drug reaction OT - pediatric oncohematology OT - pharmacogenomics OT - polygenic risk score (PGRS) OT - precision medicine COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/01 10:11 MHDA- 2026/07/01 10:12 PMCR- 2026/06/16 CRDT- 2026/07/01 05:09 PHST- 2026/03/13 00:00 [received] PHST- 2026/05/12 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/07/01 10:12 [medline] PHST- 2026/07/01 10:11 [pubmed] PHST- 2026/07/01 05:09 [entrez] PHST- 2026/06/16 00:00 [pmc-release] AID - 1830183 [pii] AID - 10.3389/fphar.2026.1830183 [doi] PST - epublish SO - Front Pharmacol. 2026 Jun 16;17:1830183. doi: 10.3389/fphar.2026.1830183. eCollection 2026. PMID- 42382020 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260701 LR - 20260813 IS - 0915-5287 (Print) IS - 2187-5626 (Electronic) IS - 0915-5287 (Linking) VI - 38 IP - 7 DP - 2026 Jul TI - Design and development of a universal OMNI exertion faces scale. PG - 324-329 LID - 10.1589/jpts.38.324 [doi] AB - [Purpose] To design and develop a new OMNI Exertion Faces Scale (OMNI Faces) that uses universal design criteria to improve acceptability for measuring perceived exertion across age groups, physical activities, and clinical populations. [Methods] The OMNI Faces Scale was developed in collaboration with the original OMNI creator and refined through consultations with educators, speech-language pathologists, clinicians, and feedback from children and adults. Design considerations included universal accessibility, simplified instructions, and alignment with the Heart Rate Reserve method. [Design Features] The OMNI Faces Scale includes five verbal descriptors and five pictorial images to reduce inconsistencies with language, activity-specific visuals, and anchoring among prior versions. The OMNI Faces Scale is non-gendered, non-activity-specific, and has accessible fonts. Instructions were simplified to 71 words relevant for assessing perceived exertion during both aerobic and resistance activities. [Conclusions] The OMNI Faces Scale was designed to provide a versatile and inclusive tool for monitoring exertion in children and adults across a broad range of physical activity applications. Future research will validate its psychometric properties across populations and activity types and explore multilingual adaptations. CI - 2026(c)by the Society of Physical Therapy Science. Published by IPEC Inc. FAU - Schlessman, Amy AU - Schlessman A AD - Department of Rehabilitation Sciences, School of Medicine, Tufts University: 145 Harrison Avenue Boston, MA, USA. FAU - Wickstrom, Rick AU - Wickstrom R AD - Workability Systems, Inc., USA. FAU - Petrosino, Chris AU - Petrosino C AD - Sacred Heart University, USA. FAU - Robertson, Robert AU - Robertson R AD - University of Pittsburgh, USA. LA - eng PT - Journal Article DEP - 20260701 PL - Japan TA - J Phys Ther Sci JT - Journal of physical therapy science JID - 9105359 PMC - PMC13318445 OTO - NOTNLM OT - OMNI Faces Scale OT - Perceived exertion OT - Physical activity COIS- Authors Rick Wickstrom (second author), Amy Schlessman (first author), and Robert Robertson (fourth author) developed the OMNI Exertion Faces Scale. Christopher Petrosino (third author) declares no conflict of interest. This universal design project to develop the OMNI Faces Exertion Scale was Dr. Robertson's last research contribution as a Professor Emeritus at the University of Pittsburgh before he passed away peacefully on November 14, 2025, at age 82. His patience, clarity, and encouragement shaped countless careers of students and colleagues and reflected his lifelong passion for exercise science across the lifespan. EDAT- 2026/07/01 06:34 MHDA- 2026/07/01 06:35 PMCR- 2026/07/01 CRDT- 2026/07/01 05:07 PHST- 2026/01/08 00:00 [received] PHST- 2026/04/17 00:00 [accepted] PHST- 2026/07/01 06:35 [medline] PHST- 2026/07/01 06:34 [pubmed] PHST- 2026/07/01 05:07 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - 2025-152 [pii] AID - 10.1589/jpts.38.324 [doi] PST - ppublish SO - J Phys Ther Sci. 2026 Jul;38(7):324-329. doi: 10.1589/jpts.38.324. Epub 2026 Jul 1. PMID- 42381602 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260828 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 3 DP - 2026 Jul TI - The Expanded Biopsychosocial Model Elucidates the Association Between Pre-Pregnancy Overweight/Obesity and Delayed Lactogenesis II: A Prospective Cohort Study. PG - e70225 LID - 10.1111/mcn.70225 [doi] LID - e70225 AB - Pre-pregnancy overweight or obesity delays the onset of lactogenesis II, posing an early barrier to achieving optimal infant nutrition and long-term health. However, the underlying pathophysiological mechanisms remain incompletely elucidated. This prospective cohort study conducted in China aimed to delineate the distinct pathways through which pre-pregnancy overweight/obesity, compared to normal body mass index (BMI), leads to delayed lactogenesis II. Guided by an expanded biopsychosocial framework, we enrolled and stratified 296 primiparous women into pre-pregnancy overweight/obese (n = 146) and normal BMI (n = 150) groups. Data on biological, psychological, social, and infant-related factors were collected prospectively at prenatal, delivery, and one-week postpartum stages. Structural equation modeling was used to identify and compare the mediating pathways between the two groups. Results demonstrated that the association between pre-pregnancy overweight/obesity and delayed lactogenesis II was primarily mediated through four distinct pathways: biological (e.g., breastfeeding difficulties: beta = 0.203, 95% CI: 0.144-0.265, p < 0.001), psychological (e.g., internalized weight stigma: beta = 0.095, 95% CI: 0.016-0.181, p = 0.026), social (e.g., reduced pro-breastfeeding practices: beta = 0.076, 95% CI: 0.017-0.144, p = 0.019), and infant-related (e.g., higher formula intake: beta = 0.114, 95% CI: 0.047-0.195, p = 0.003). This study validates the expanded biopsychosocial model by elucidating the distinct pathways through which pre-pregnancy overweight/obesity contributes to delayed lactogenesis II. These findings underscore the necessity for clinical practice to move beyond a purely biological focus and advocate for a paradigm shift in clinical support towards integrated, multi-faceted interventions tailored to this vulnerable population. TRIAL REGISTRATION: This study was registered at the Chinese Clinical Trial Registry (registry number: ChiCTR2200057038). The trial was registered on February 26, 2022. CI - (c) 2026 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Ren, Ziqi AU - Ren Z AUID- ORCID: 0000-0002-5285-5794 AD - School of Nursing, Nanjing Medical University, Nanjing, Jiangning District, China. FAU - Zhang, Aixia AU - Zhang A AUID- ORCID: 0000-0002-1266-0925 AD - Department of Nursing, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Healthcare Hospital), Nanjing, Qinhuai District, China. FAU - Zhang, Jingjing AU - Zhang J AD - Department of Nursing, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Healthcare Hospital), Nanjing, Qinhuai District, China. FAU - Fan, Xuemei AU - Fan X AD - Department of Nursing, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Healthcare Hospital), Nanjing, Qinhuai District, China. FAU - Tang, Huiting AU - Tang H AD - School of Nursing, Nanjing Medical University, Nanjing, Jiangning District, China. LA - eng GR - 72204123/National Natural Science Foundation of China Youth Program/ GR - FNF202102/Nursing Scientific Research at Fudan University/ GR - Jiangsu Education Departmentleft broken bracket2023right broken bracketNo.11/Project of "Nursing Science" Funded by the 4th Priority Discipline Development Program of Jiangsu Higher Education Institutions/ PT - Journal Article PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - Female MH - Prospective Studies MH - Pregnancy MH - Adult MH - *Overweight/physiopathology MH - *Lactation/physiology/psychology MH - Breast Feeding/psychology/statistics & numerical data MH - *Obesity/physiopathology MH - China/epidemiology MH - Body Mass Index MH - *Pregnancy Complications MH - Infant, Newborn PMC - PMC13320373 OTO - NOTNLM OT - biopsychosocial model OT - breastfeeding OT - lactogenesis II OT - maternity care OT - mechanisms OT - mediating pathways OT - pre-pregnancy obesity COIS- The authors declare no conflicts of interest. EDAT- 2026/07/01 06:33 MHDA- 2026/07/01 16:11 PMCR- 2026/07/01 CRDT- 2026/07/01 04:53 PHST- 2026/04/07 00:00 [revised] PHST- 2025/12/11 00:00 [received] PHST- 2026/06/13 00:00 [accepted] PHST- 2026/07/01 16:11 [medline] PHST- 2026/07/01 06:33 [pubmed] PHST- 2026/07/01 04:53 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - MCN70225 [pii] AID - 10.1111/mcn.70225 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Jul;22(3):e70225. doi: 10.1111/mcn.70225. PMID- 42380694 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260831 IS - 1463-1326 (Electronic) IS - 1462-8902 (Print) IS - 1462-8902 (Linking) VI - 28 IP - 9 DP - 2026 Sep TI - Pubertal Stage-Based One-hour Postload Glucose Thresholds Improve Identification of Prediabetes and Type 2 Diabetes in Children With Overweight or Obesity. PG - 8469-8481 LID - 10.1111/dom.70969 [doi] AB - AIMS: One-hour postload plasma glucose (1h-PG) is an early marker of dysglycemia in adults, but its utility in children and adolescents is uncertain because insulin sensitivity changes during growth and puberty. We aimed to establish age- and pubertal stage-specific 1h-PG thresholds for identifying prediabetes and Type 2 diabetes (T2D) in children with overweight or obesity. MATERIALS AND METHODS: In this cross-sectional study, 4344 children and adolescents with overweight or obesity underwent an oral glucose tolerance test. Participants were classified into four groups: normal glucose tolerance (NGT) with normal 1 h-PG, NGT with elevated 1 h-PG, prediabetes and T2D. Insulin resistance and beta-cell function indices were assessed. Participants were stratified by chronological age and pubertal stage. The optimal 1h-PG cut-offs were obtained via receiver operating characteristic (ROC) and age- and pubertal stage-based thresholds were compared for diagnostic performance. These thresholds were then validated in two independent cohorts. RESULTS: Among individuals with NGT, those with elevated 1h-PG exhibited greater insulin resistance, impaired beta-cell function and a higher insulin area under the curve (29 916 vs. 23 524, p < 0.001). 1 h-PG levels increased with pubertal progression. Pubertal stage-specific thresholds showed superior discrimination compared with age-based stratification and adult cut-offs. Compared with adult thresholds (8.6 mmol/L for prediabetes and 11.6 mmol/L for T2D), a prepubertal cut-off of 7.78 mmol/L improved sensitivity for prediabetes (75.40% vs. 56.68%) and a pubertal cut-off of 10.48 mmol/L improved sensitivity for T2D (89.47% vs. 73.68%). CONCLUSIONS: Elevated 1h-PG proved to be a practical marker for identifying early metabolic dysfunction in children and adolescents with euglycemia. Given that widely used adult-derived cut-offs (8.6 and 11.6 mmol/L) are suboptimal for pediatric populations, we established pubertal stage-specific thresholds that outperformed both age-specific and adult-derived cut-offs. These stage-specific thresholds may serve as an effective screening tool for diabetes risk in children and adolescents with overweight or obesity. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Wu, Zhaoyuan AU - Wu Z AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Li, Yangxi AU - Li Y AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Qin, Zhewen AU - Qin Z AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Liu, Yaru AU - Liu Y AUID- ORCID: 0000-0002-9758-5951 AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Le, Kaixing AU - Le K AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Zhou, Xuelian AU - Zhou X AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Sun, Yan AU - Sun Y AD - Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. FAU - Huang, Ke AU - Huang K AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Wu, Wei AU - Wu W AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Dong, Guanping AU - Dong G AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Fu, Junfen AU - Fu J AUID- ORCID: 0000-0001-6405-1251 AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. LA - eng GR - 2023ZD0508200/Noncommunicable Chronic Diseases-National Science and Technology Major Project/ GR - 2023ZD0508204/Noncommunicable Chronic Diseases-National Science and Technology Major Project/ GR - Zhejiang Province Multidisciplinary Innovative Team for the Diagnosis and Treatment of Diabetes with Traditional Chinese Medicine/ GR - YXH2024YS028/2024 Shandong Medical Association Scientific Research Project/ PT - Journal Article DEP - 20260630 PL - England TA - Diabetes Obes Metab JT - Diabetes, obesity & metabolism JID - 100883645 RN - 0 (Blood Glucose) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/diagnosis/blood/complications MH - *Prediabetic State/diagnosis/blood/complications MH - Male MH - Child MH - Female MH - Adolescent MH - Cross-Sectional Studies MH - Glucose Tolerance Test MH - *Puberty/blood MH - *Blood Glucose/metabolism/analysis MH - Insulin Resistance MH - *Pediatric Obesity/complications/blood MH - *Overweight/complications/blood MH - Biomarkers/blood MH - Insulin-Secreting Cells PMC - PMC13448984 OTO - NOTNLM OT - 1-h postprandial plasma glucose OT - Type 2 diabetes OT - children OT - insulin resistance OT - beta cell function COIS- The authors declare no conflicts of interest. EDAT- 2026/07/01 10:11 MHDA- 2026/08/07 12:39 PMCR- 2026/08/07 CRDT- 2026/07/01 00:27 PHST- 2026/05/25 00:00 [revised] PHST- 2026/03/05 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/08/07 12:39 [medline] PHST- 2026/07/01 10:11 [pubmed] PHST- 2026/07/01 00:27 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - DOM70969 [pii] AID - 10.1111/dom.70969 [doi] PST - ppublish SO - Diabetes Obes Metab. 2026 Sep;28(9):8469-8481. doi: 10.1111/dom.70969. Epub 2026 Jun 30. PMID- 42379099 OWN - NLM STAT- MEDLINE DCOM- 20261021 LR - 20261021 IS - 1879-1271 (Electronic) IS - 0268-0033 (Linking) VI - 138 DP - 2026 Aug TI - Exploring real-world lumbar posture behaviour. A whole day comparison of individuals with low back pain and healthy controls. PG - 106908 LID - S0268-0033(26)00163-4 [pii] LID - 10.1016/j.clinbiomech.2026.106908 [doi] AB - BACKGROUND: Previous research of lumbar posture on individuals with low back pain (LBP) has produced conflicting findings compared to control groups. This research has been limited by environmental or task constraints. Real-world postural behaviour across an entire day remains poorly understood. This study examined whole-day lumbar posture characteristics in people with and without LBP using wearable sensors. METHODS: 13 people with LBP and 11 healthy controls volunteered for this study. A three-accelerometer setup was used to measure real-world lumbar posture classifying sitting and standing. Data were normalised to individual maximum ranges. Differences in measures of mean posture, variability, fidgeting, and posture-use frequency distributions, were derived. FINDINGS: An average of 350 min of data per person was available for analysis. Overall, between group differences were small. LBP demonstrated more flexed posture use in standing and a more flexed sitting frequency distribution. INTERPRETATION: Real-world posture behaviour was similar between individuals with and without LBP. Where differences were determined they related to temporal components such as frequencies which are masked with traditional postural estimates. These findings suggest that posture-pain relationships may vary substantially between individuals, emphasising the need for person-specific analysis in future research. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - McClintock, Frederick A AU - McClintock FA AD - Department of Rehabilitation and Sport Sciences, Bournemouth University, Bournemouth, UK. Electronic address: fmcclintock@bournemouth.ac.uk. FAU - Callaway, Andrew J AU - Callaway AJ AD - Department of Rehabilitation and Sport Sciences, Bournemouth University, Bournemouth, UK. FAU - Clark, Carol J AU - Clark CJ AD - Department of Rehabilitation and Sport Sciences, Bournemouth University, Bournemouth, UK. FAU - Munoz-Gomez, Elena AU - Munoz-Gomez E AD - Research Unit in Clinical Biomechanics (UBIC), Department of Physiotherapy, Faculty of Physiotherapy, University of Valencia, 46010, Valencia, Spain. FAU - Alqhtani, Raee S AU - Alqhtani RS AD - College of Applied Medical Science, Najran University, Najran, P.O. Box 1988, Saudi Arabia. FAU - Williams, Jonathan M AU - Williams JM AD - Department of Rehabilitation and Sport Sciences, Bournemouth University, Bournemouth, UK. LA - eng PT - Comparative Study PT - Comparative Study PT - Journal Article PT - Observational Study DEP - 20260629 PL - England TA - Clin Biomech (Bristol) JT - Clinical biomechanics (Bristol, Avon) JID - 8611877 SB - IM MH - *Posture/physiology MH - *Low Back Pain/physiopathology MH - *Lumbar Vertebrae/physiopathology MH - Case-Control Studies MH - Wearable Electronic Devices MH - Healthy Volunteers MH - Accelerometry/instrumentation MH - Sitting Position MH - Standing Position MH - Cross-Sectional Studies MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged OTO - NOTNLM OT - Discomfort OT - Ecological validity OT - Field-based OT - Lordosis OT - Provocation OT - Spine OT - Variability COIS- Declaration of competing interest The authors declare no conflict of interest. EDAT- 2026/07/01 00:35 MHDA- 2026/07/15 12:37 CRDT- 2026/06/30 18:09 PHST- 2025/11/13 00:00 [received] PHST- 2026/03/27 00:00 [revised] PHST- 2026/06/28 00:00 [accepted] PHST- 2026/07/15 12:37 [medline] PHST- 2026/07/01 00:35 [pubmed] PHST- 2026/06/30 18:09 [entrez] AID - S0268-0033(26)00163-4 [pii] AID - 10.1016/j.clinbiomech.2026.106908 [doi] PST - ppublish SO - Clin Biomech (Bristol). 2026 Aug;138:106908. doi: 10.1016/j.clinbiomech.2026.106908. Epub 2026 Jun 29. PMID- 42378256 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260926 IS - 2369-2960 (Electronic) IS - 2369-2960 (Linking) VI - 12 DP - 2026 Jun 30 TI - Comparison of Measured 24-Hour Urinary Salt Excretion With Spot Urine and 24-Hour Dietary Recall Estimates Among Adolescents and Parents: Cross-Sectional Study. PG - e85549 LID - 10.2196/85549 [doi] LID - e85549 AB - BACKGROUND: Hypertension, a leading cause of cardiovascular disease, is a significant public health challenge, with urban India reporting prevalence rates up to 40%. Excessive salt intake, averaging 8 to 11 g/day in India, far exceeds the World Health Organization-recommended limit of 5 g/day and is a key modifiable risk factor. While 24-hour urine collection is the gold standard for measuring 24-hour urinary excreted salt levels, its practicality in large-scale studies is limited, necessitating alternative methods such as spot urine sampling and dietary recall. OBJECTIVE: This study aimed to address current knowledge gaps by evaluating 24-hour urinary excretory salt levels across age groups and comparing the gold standard of 24-hour urinary salt excretion with estimates from spot urine samples and 24-hour dietary recalls among adolescents and their parents in Chandigarh, India. METHODS: A cross-sectional survey was conducted among 462 adolescents and 395 parents from public schools in Chandigarh, part of a cluster randomized controlled trial focused on reducing chronic disease risk factors. Twenty-four-hour urinary excreted salt levels were measured via 24-hour urine collection, spot urine samples were analyzed with the Kawasaki, Tanaka, and INTERSALT equations, and 2 nonconsecutive 24-hour dietary recalls using a correction factor of 0.9. Bland-Altman plots were used to assess agreement between methods. RESULTS: The mean 24-hour urinary excreted salt levels measured via 24-hour urine samples were 6.95 g/day (SD 0.24; 95% CI 6.48-7.42) for adolescents and 7.73 g/day (SD 0.3; 95% CI 7.18-8.28) for parents. Spot urine estimates showed variability, with the INTERSALT equation with potassium yielding the closest results to 24-hour measurements for parents (mean 8.12, SD 0.4 g/d; 95% CI 7.36-8.95) and adolescents (mean 7.97, SD 0.4 g/day; 95% CI 7.16-8.77). Dietary recall underestimated 24-hour urinary excreted salt levels for both groups (mean 4.15, SD 0.08 g/day for adolescents and mean 3.62, SD 0.08 g/day for parents). CONCLUSIONS: Spot urine sampling, particularly the INTERSALT with potassium equation, offers a feasible alternative to 24-hour urine collection for estimating population-level 24-hour urinary excreted salt levels among adolescents and adults in resource-limited settings. Dietary recall alone significantly underestimates intake and should be supplemented with objective measures. These findings support the use of tailored estimation methods based on age for improved hypertension management strategies in India. CI - (c) Sandeep Kaur, Akashdeep Singh Chauhan, Rajesh Kumar, Manmeet Kaur. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org). FAU - Kaur, Sandeep AU - Kaur S AUID- ORCID: 0000-0003-3170-6703 AD - Faculty of Medicine, Imperial College London, Hammersmith Campus, London, W120NN, United Kingdom, 44 7570297460. AD - Indian Institute of Public Health-Delhi, Public Health Foundation of India, New Delhi, India. AD - Department of Community Medicine and School of Public Health, Post Graduate Institute of Medical Education and Research, Chandigarh, India. FAU - Chauhan, Akashdeep Singh AU - Chauhan AS AUID- ORCID: 0000-0001-6791-2221 AD - Indian Institute of Public Health-Delhi, Public Health Foundation of India, New Delhi, India. AD - Department of Community Medicine and School of Public Health, Post Graduate Institute of Medical Education and Research, Chandigarh, India. FAU - Kumar, Rajesh AU - Kumar R AUID- ORCID: 0000-0001-9750-3437 AD - Department of Community Medicine and School of Public Health, Post Graduate Institute of Medical Education and Research, Chandigarh, India. AD - Health Equity Action Learnings Foundation, Chandigarh, India. FAU - Kaur, Manmeet AU - Kaur M AUID- ORCID: 0000-0003-2450-3115 AD - Department of Community Medicine and School of Public Health, Post Graduate Institute of Medical Education and Research, Chandigarh, India. AD - Health Equity Action Learnings Foundation, Chandigarh, India. LA - eng SI - CTRI/CTRI/2019/09/021452 PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260630 PL - Canada TA - JMIR Public Health Surveill JT - JMIR public health and surveillance JID - 101669345 RN - 0 (Sodium Chloride, Dietary) SB - IM MH - Humans MH - Adolescent MH - Cross-Sectional Studies MH - Male MH - India/epidemiology MH - Female MH - *Sodium Chloride, Dietary/urine MH - *Urine Specimen Collection/methods MH - *Parents/psychology MH - Child MH - Adult MH - *Urinalysis/methods MH - *Mental Recall PMC - PMC13317844 OTO - NOTNLM OT - 24-hour urine collection OT - adolescents OT - cardiovascular diseases OT - chronic diseases OT - dietary recall OT - excretory salt OT - hypertension OT - spot urine sampling OT - urinary excreted salt levels COIS- Conflicts of Interest: None declared. EDAT- 2026/06/30 22:37 MHDA- 2026/06/30 22:38 PMCR- 2026/06/30 CRDT- 2026/06/30 13:42 PHST- 2025/10/10 00:00 [received] PHST- 2026/04/30 00:00 [revised] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/06/30 22:38 [medline] PHST- 2026/06/30 22:37 [pubmed] PHST- 2026/06/30 13:42 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - v12i1e85549 [pii] AID - 85549 [pii] AID - 10.2196/85549 [doi] PST - epublish SO - JMIR Public Health Surveill. 2026 Jun 30;12:e85549. doi: 10.2196/85549. PMID- 42377367 OWN - NLM STAT- MEDLINE DCOM- 20260720 LR - 20260820 IS - 1699-5198 (Electronic) IS - 0212-1611 (Linking) VI - 43 IP - Spec No4 DP - 2026 Jul 20 TI - EnComCol Study on the diet of children and young people at home and in schools: design and methodology. PG - 41-45 LID - 10.20960/nh.06963 [doi] AB - EnComCol is an observational, crosssectional, multicentre study assessing diet in Spanish children and adolescents (6-17 years) by comparing intake at home with that in the school canteen. It is framed by the continuing burden of childhood overweight/obesity and Royal Decree 315/2025, which harmonises criteria for school menus and portions. The main aim is to identify differences in foods, beverages and nutrient intake according to canteen use, school ownership (public, charter, or private) and residence across six mainland regions, considering six daily mealtimes eating occasions. The sample comprises 1,000 urban participants, balanced by age (50 % 6-11; 50 % 12-17) and sex, with quotas for school type (75 % public, 20 % charter, 5 % private) and geographic distribution using Nielsen areas. For ages 6-11, quotas ensure a 50/50 split between canteen users and nonusers. Methods include a structured 24 hours recall dietary record plus sociodemographic, anthropometric and lifestyle variables. Data collection has three phases: recruitment and a technology-assisted interview; a food diary with telephone interview; and researcher telephone validation, with digital coding and nutrient conversion using updated food-composition tables. Analyses will use descriptive and inferential statistics, mean/proportion comparisons, multivariable models and stratification by age, sex, school type, canteen use and region (p < 0.05). Findings will enable direct comparison with prior research and quantification of critical nutrients (saturated fat, sugars and salt) across contexts. FAU - Urrialde, Rafael AU - Urrialde R AD - Department of Genetics, Physiology and Microbiology. Faculty of Biological Sciences. Universidad Complutense de Madrid. Grupo de Investigacion en Nutricion, Ejercicio y Estilo de Vida Saludable-ImFINE. Department of Health and Human Performance. Universid. FAU - Modrego, Javier AU - Modrego J AD - Grupo de Investigacion en Nutricion, Ejercicio y Estilo de Vida Saludable-ImFINE. Department of Health and Human Performance. Universidad Politecnica de Madrid. Sociedad Espanola de Nutricion (SEN). Faculty of Physical Activity and Sports Sciences (INEF). FAU - Gesteiro, Eva AU - Gesteiro E AD - Grupo de Investigacion en Nutricion, Ejercicio y Estilo de Vida Saludable-ImFINE. Department of Health and Human Performance. Universidad Politecnica de Madrid. Sociedad Espanola de Nutricion (SEN). Faculty of Physical Activity and Sports Sciences (INEF). FAU - Zapico, Augusto G AU - Zapico AG AD - Grupo de Investigacion en Nutricion, Ejercicio y Estilo de Vida Saludable-ImFINE. Department of Health and Human Performance. Universidad Politecnica de Madrid. Sociedad Espanola de Nutricion (SEN). Faculty of Physical Activity and Sports Sciences (INEF). FAU - Lopez Flores, Jessica AU - Lopez Flores J AD - Grupo de Investigacion en Nutricion, Ejercicio y Estilo de Vida Saludable-ImFINE. Department of Health and Human Performance. Universidad Politecnica de Madrid. Sociedad Espanola de Nutricion (SEN). Faculty of Physical Activity and Sports Sciences (INEF). FAU - Gonzalez-Gross, Marcela AU - Gonzalez-Gross M AD - ImFINE Research Group, Health and Human Performance Department, Faculty of Physical Activity and Sport Sciences, Universidad Politecnica de Madrid, 28040 Madrid. LA - eng PT - Journal Article PT - Multicenter Study PT - Observational Study TT - Estudio EnComCol sobre alimentacion en poblacion infantil y juvenil en el hogar y colegios: diseno y metodologia. PL - Spain TA - Nutr Hosp JT - Nutricion hospitalaria JID - 9100365 SB - IM MH - Humans MH - Child MH - Female MH - *Schools MH - Male MH - Adolescent MH - *Diet MH - Cross-Sectional Studies MH - Spain/epidemiology MH - Research Design MH - Diet Records OTO - NOTNLM OT - Comedor escolar. Registro dietetico de 24 horas. Registro estilo de vida. Nutrientes criticos. Ninos. Adolescentes. EDAT- 2026/06/30 16:10 MHDA- 2026/07/20 06:38 CRDT- 2026/06/30 10:53 PHST- 2026/07/20 06:38 [medline] PHST- 2026/06/30 16:10 [pubmed] PHST- 2026/06/30 10:53 [entrez] AID - 10.20960/nh.06963 [doi] PST - ppublish SO - Nutr Hosp. 2026 Jul 20;43(Spec No4):41-45. doi: 10.20960/nh.06963. PMID- 42376369 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260630 LR - 20260813 IS - 2174-0852 (Electronic) IS - 1697-2600 (Print) IS - 1697-2600 (Linking) VI - 26 IP - 2 DP - 2026 Apr-Jun TI - Accelerometer-derived movement phenotypes and adolescent mental health in pediatric obesity: A causal machine-learning study. PG - 100704 LID - 10.1016/j.ijchp.2026.100704 [doi] LID - 100704 AB - BACKGROUND: Children with overweight or obesity are at elevated risk for later-life mental health challenges, but the role of accelerometer-derived waking movement behaviors remains uncertain. Thus, we examined longitudinal associations of sedentary behavior (SB), light-intensity physical activity (LPA), and moderate-to-vigorous-intensity physical activity (MVPA) at age 7 with later-life internalizing and externalizing problems. METHOD: We used data from the UK Millennium Cohort Study, focusing on children with overweight or obesity at age 7 who had valid accelerometer data and a complete set of predefined analytic variables (N = 858). Exposures were average daily minutes of SB, LPA, and MVPA. Outcomes were parent-reported Strengths and Difficulties Questionnaire-based internalizing and externalizing problems scores at ages 11 and 14. A generalized random forests approach was used to estimate average treatment effects (ATEs) and conditional average treatment effects (CATEs), adjusted for relevant demographic, socioeconomic, body mass index, parental distress, baseline mental health, and co-occurring movement intensities; day-of-week activity-pattern variables were used as exploratory candidate moderators. RESULTS: Estimated ATEs were small. After applying the Benjamini-Hochberg false-discovery-rate (FDR) correction across the 12 primary exposure-outcome tests, only the association between higher SB and lower internalizing problems at age 11 remained statistically significant (ATE = -0.013 SDQ points per additional min/day; 95% CI, -0.019 to -0.007; q < 0.001). No other pathway survived FDR correction, and other nominal or directionally suggestive estimates were interpreted as exploratory. CATE summaries and calibration tests provided limited evidence of reproducible heterogeneity. CONCLUSIONS: Accelerometer-derived waking movement behaviors at age 7 were associated with later SDQ problems scores in small and outcome-specific ways among children with overweight or obesity. Since the study is based on observational data and relies on measured-confounder assumptions, the findings should be interpreted cautiously, and as model-based estimates rather than definitive causal evidence. CI - (c) 2026 Published by Elsevier B.V. FAU - Pan, Siyu AU - Pan S AD - School of psychology, Wuhan Sports University, Wuhan, China. FAU - Wang, Peng AU - Wang P AD - School of psychology, Wuhan Sports University, Wuhan, China. AD - Department of Language, Literature, and Communication, Faculty of Humanities, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, the Netherlands. AD - Department of Psychology, Education, and Child Studies, Erasmus University Rotterdam, Rotterdam, P.O. Box 1738, the Netherlands. FAU - Herold, Fabian AU - Herold F AD - Department of Physiology, Faculty of Medicine, HMU Health and Medical University Erfurt, Erfurt, Thuringia 99089, Germany. FAU - Heath, Matthew AU - Heath M AD - School of Kinesiology, Faculty of Health Sciences, University of Western Ontario, 1151 Richmond St, London, ON N6A 3K7, Canada. AD - Graduate Program in Neuroscience, University of Western Ontario, 1151 Richmond St, London, ON N6A 3K7, Canada. AD - Canadian Centre for Activity and Aging, University of Western Ontario, 1201 Western Rd, London, ON, N6G 1H1 Canada. FAU - Lee, Edmund Wei Jian AU - Lee EWJ AD - Department of Media and Communication, College of Liberal Arts and Social Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, China. FAU - Law, Effie Lai-Chong AU - Law EL AD - Department of Computer Science (Human-Computer Interaction Group), Durham University, Durham, UK. FAU - Lowe, Cassandra J AU - Lowe CJ AD - Department of Psychology, University of Exeter, UK. FAU - Werneck, Andre AU - Werneck A AD - Center for Epidemiological Research in Nutrition and Health, Department of Nutrition, School of Public Health, Universidade de Sao Paulo, Sao Paulo, Brazil. FAU - Gerber, Markus AU - Gerber M AD - Department of Sport, Exercise and Health, Faculty of Medicine, University of Basel, Grosse Allee 6, Basel 4052, Switzerland. FAU - Moreau, David AU - Moreau D AD - School of Psychology and Centre for Brain Research, University of Auckland, Auckland 1030 New Zealand. FAU - Mavilidi, Myrto AU - Mavilidi M AD - Faculty of Education, Southern Cross University, Lismore, Australia. AD - Physical Activity, Sport and Exercise (PASER) Research Theme, Southern Cross University, Lismore, Australia. FAU - Paas, Fred AU - Paas F AD - Department of Psychology, Education, and Child Studies, Erasmus University Rotterdam, Rotterdam, P.O. Box 1738, the Netherlands. AD - School of Education, University of New South Wales, Sydney, NSW 1466, Australia. FAU - Hallgren, Mats AU - Hallgren M AD - Department of Public Health Sciences, Karolinska Institutet, Nobels vag 12A, Stockholm 17177, Sweden. FAU - Xu, Xia AU - Xu X AD - School of psychology, Wuhan Sports University, Wuhan, China. FAU - Zou, Liye AU - Zou L AD - School of psychology, Wuhan Sports University, Wuhan, China. LA - eng PT - Journal Article DEP - 20260620 PL - Spain TA - Int J Clin Health Psychol JT - International journal of clinical and health psychology : IJCHP JID - 101237969 PMC - PMC13312474 OTO - NOTNLM OT - Accelerometry OT - Causal machine learning OT - Digital phenotyping OT - Mental health OT - Pediatric obesity OT - Wearable sensors COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/30 06:31 MHDA- 2026/06/30 06:32 PMCR- 2026/06/20 CRDT- 2026/06/30 05:27 PHST- 2026/04/04 00:00 [received] PHST- 2026/06/13 00:00 [accepted] PHST- 2026/06/30 06:32 [medline] PHST- 2026/06/30 06:31 [pubmed] PHST- 2026/06/30 05:27 [entrez] PHST- 2026/06/20 00:00 [pmc-release] AID - S1697-2600(26)00040-2 [pii] AID - 100704 [pii] AID - 10.1016/j.ijchp.2026.100704 [doi] PST - ppublish SO - Int J Clin Health Psychol. 2026 Apr-Jun;26(2):100704. doi: 10.1016/j.ijchp.2026.100704. Epub 2026 Jun 20. PMID- 42376252 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260630 LR - 20260813 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Sense of Coherence in patients with stable schizophrenia: multidimensional determinants from a cross-sectional study of 438 inpatients in Guangzhou, China. PG - 1750488 LID - 10.3389/fpsyt.2026.1750488 [doi] LID - 1750488 AB - INTRODUCTION: Schizophrenia, a chronic psychiatric disorder, profoundly affects social functioning and quality of life. The Sense of Coherence (SOC), a core construct in salutogenic theory, plays a pivotal role in stress coping and recovery outcomes. While SOC has been studied in general populations, its determinants in stabilized schizophrenia inpatients remain underexplored. This study comprehensively investigated the Sense of Coherence (SOC) profile among stabilized schizophrenia inpatients by assessing its current status, exploring the interrelationships between SOC and demographic factors/Big Five personality traits (CBF-PI)/social support (SSRS), and identifying factors associated with SOC to inform potential personalized resilience-enhancing interventions. Findings may guide clinical strategies to enhance resilience and mental health recovery and potentially facilitate functional recovery in this population. PATIENTS AND METHODS: A cross-sectional study was conducted at a Guangzhou tertiary psychiatric hospital with 438 stabilized schizophrenia inpatients from November 2024 to February 2025. Data collection included demographic/clinical variables, Chinese Big Five Personality Inventory (CBF-PI), 13-item Sense of Coherence Scale (SOC-13), and the Social Support Rating Scale (SSRS). Statistical analyses were performed using SPSS version 27.0. Descriptive statistics were used to summarize the data and independent-samples t-tests and one-way analysis of variance (ANOVA) were employed to compare SOC scores across demographic and clinical groups. Pearson correlation analysis was conducted to examine the relationships between personality traits, social support, and sense of coherence and multiple linear regression analysis was utilized to identify independent factors influencing sense of coherence (P < 0.05). RESULT: The mean SOC score among the 438 stabilized schizophrenia inpatients was 53.35 +/- 11.81. SOC correlated positively with all five dimensions of CBF-PI-B (P < 0.05), as well as subjective social support (P < 0.01), while showing inverse correlations with objective support (p < 0.01) and support utilization subscales (P < 0.01), Multiple regression identified personal income(yes), frequency of physical activity (>/=3 times/week), and primary caregiver (Children) as significant SOC predictors. CONCLUSION: This study demonstrates that stabilized schizophrenia inpatients in a tertiary psychiatric setting exhibit generally lower Sense of Coherence (SOC) levels compared with healthy normative values and moderately lower than several outpatient schizophrenia samples. Higher SOC was significantly associated with having a personal income, frequent physical activity (>/=3 times/week), having children as primary caregivers, and Chinese Big Five Personality traits. Notably, while subjective support was positively correlated with SOC, objective support and support utilization showed negative associations. Given the moderate internal consistency of the SSRS (Cronbach's alpha = 0.626), the differential associations with social support dimensions should be interpreted cautiously. Concurrently, personality traits are relatively stable, their associations with SOC may inform indirect supportive strategies leveraging existing strengths rather than direct modification. These findings underscore the potential value of tailored interventions that enhance subjective support, promote structured recreational activities, and foster patients' perceived coping resources. Further cross-sectional and longitudinal outpatient studies are warranted to validate these results and elucidate the mechanisms underlying the support paradox. CI - Copyright (c) 2026 Liang, Niu, Huang, Chen, Wu, Chen, Liu, Shi and Zeng. FAU - Liang, Rongyu AU - Liang R AD - Department of Geriatric Psychiatry, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China. AD - Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. FAU - Niu, Zangrui AU - Niu Z AD - School of Nursing, Guangzhou Medical University, Guangzhou, China. FAU - Huang, Yuanyuan AU - Huang Y AD - Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. AD - Department of Psychiatry, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China. AD - Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China. FAU - Chen, Xiezhen AU - Chen X AD - School of Nursing, Guangzhou Medical University, Guangzhou, China. FAU - Wu, Fengchun AU - Wu F AD - Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. AD - Department of Psychiatry, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China. AD - Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China. FAU - Chen, Xiaodong AU - Chen X AD - Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. AD - Chronic Psychiatry Department, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Liu, Cuixia AU - Liu C AD - Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. AD - Chronic Psychiatry Department, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Shi, Xiaolei AU - Shi X AD - Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. AD - Cerebrovascular Disease Department, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Zeng, Gang AU - Zeng G AD - Nursing Department, Guangzhou Chest Hospital Affiliated to Guangdong Pharmaceutical University, Guangzhou, China. AD - State Key Laboratory of Respiratory Disease, Guangzhou, China. AD - Institute of Tuberculosis, Guangzhou Medical University, Guangzhou, China. LA - eng PT - Journal Article DEP - 20260615 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13311124 OTO - NOTNLM OT - Big Five Personality OT - Sense of Coherence OT - inpatients OT - schizophrenia OT - social support COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/30 06:31 MHDA- 2026/06/30 06:32 PMCR- 2026/06/15 CRDT- 2026/06/30 05:25 PHST- 2025/12/18 00:00 [received] PHST- 2026/03/12 00:00 [revised] PHST- 2026/03/12 00:00 [accepted] PHST- 2026/06/30 06:32 [medline] PHST- 2026/06/30 06:31 [pubmed] PHST- 2026/06/30 05:25 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1750488 [doi] PST - epublish SO - Front Psychiatry. 2026 Jun 15;17:1750488. doi: 10.3389/fpsyt.2026.1750488. eCollection 2026. PMID- 42376024 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260630 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Characteristics, predictors, and management of post-extubation dysphagia in critically Ill children: a scoping review. PG - 1854127 LID - 10.3389/fped.2026.1854127 [doi] LID - 1854127 AB - BACKGROUND: Post-extubation dysphagia (PED) is a common complication in critically ill children, associated with aspiration, malnutrition, and prolonged hospitalization. Standardized pediatric-specific assessment and management pathways are lacking, and published studies show substantial heterogeneity in diagnostic criteria, assessment timing, and intervention strategies. OBJECTIVE: This scoping review maps available evidence on pediatric PED, addressing: (1) incidence and clinical characteristics; (2) categories and effect sizes of independent predictors; and (3) the current state of prediction tools, bedside screening instruments, and management strategies. METHODS: Nine databases were searched systematically-PubMed, Embase, Cochrane Library, Web of Science, CINAHL, CNKI, Wanfang, VIP, and CBM-with a search cutoff of 12 March 2026. Fifteen studies were included, encompassing cohort studies, randomized controlled trials, quasi-experimental studies, and scale-development studies. Data were synthesized narratively following the JBI scoping review methodological framework. RESULTS: Included studies were published between 2018 and 2026; 73.3% (11/15) appeared after 2022, originating primarily from mainland China (n = 10) and Brazil (n = 3). The clinical apparent incidence ranged from 28.36% to 68.94%. No included bedside assessment instrument was validated against VFSS or FEES,representing a central methodological gap in the current evidence base.Independent predictors were categorized into three evidence tiers: Tier 1: intubation duration, age, and IWS; Tier 2: neurological comorbidities and number of intubations >/=2; Tier 3:delirium.The CRISPED score is the only prediction tool with temporal internal validation (C-statistic 0.85-0.86). No assessment instrument has been validated against an instrumental gold standard. Interventions centered on oral motor training, with no standardization in frequency, intensity, or multidisciplinary integration. CONCLUSION: Pediatric PED incidence is high and core risk factors have been repeatedly reported across multiple multivariable models, but the field shows substantial heterogeneity in diagnostic definitions, assessment tools, and intervention protocols. The absence of instrumental validation for bedside assessment tools is the central limitation. Key gaps include the absence of gold-standard diagnostic accuracy studies, externally validated prediction models, and standardized intervention pathways. Future research should prioritize multicenter prospective studies to unify diagnostic criteria, develop age-appropriate bedside screening tools, and establish a nurse-led multidisciplinary management framework. SYSTEMATIC REVIEW REGISTRATION: Open Science Framework (OSF), identifier doi: 10.17605/OSF.IO/XSJ9B. CI - (c) 2026 Xue, Zhang, Zhao, Hu, Ju, Sun, Zhang, Zhang, Yang and Guan. FAU - Xue, Yaokang AU - Xue Y AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. AD - School of Nursing, Jilin University, Changchun, China. FAU - Zhang, Baorong AU - Zhang B AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. FAU - Zhao, Xiaoshuang AU - Zhao X AD - Department of Nursing, The First Hospital of Jilin University, Changchun, China. FAU - Hu, Lili AU - Hu L AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. FAU - Ju, Liting AU - Ju L AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. AD - School of Nursing, Jilin University, Changchun, China. FAU - Sun, Hairui AU - Sun H AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. FAU - Zhang, Dan AU - Zhang D AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. FAU - Zhang, Jiping AU - Zhang J AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. FAU - Yang, Yuxuan AU - Yang Y AD - School of Nursing, Jilin University, Changchun, China. FAU - Guan, Ruixin AU - Guan R AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260615 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13311104 OTO - NOTNLM OT - management strategies OT - pediatric intensive care OT - pediatrics OT - post-extubation dysphagia OT - predictors OT - scoping review COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/30 06:31 MHDA- 2026/06/30 06:32 PMCR- 2026/06/15 CRDT- 2026/06/30 05:22 PHST- 2026/04/13 00:00 [received] PHST- 2026/05/18 00:00 [revised] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/06/30 06:32 [medline] PHST- 2026/06/30 06:31 [pubmed] PHST- 2026/06/30 05:22 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.3389/fped.2026.1854127 [doi] PST - epublish SO - Front Pediatr. 2026 Jun 15;14:1854127. doi: 10.3389/fped.2026.1854127. eCollection 2026. PMID- 42375697 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260630 LR - 20260813 IS - 2673-4842 (Electronic) IS - 2673-4842 (Linking) VI - 7 DP - 2026 TI - Identifying dietary patterns and their association with oral health behaviors in young children: a parent-based cross-sectional study in Lithuania. PG - 1844389 LID - 10.3389/froh.2026.1844389 [doi] LID - 1844389 AB - BACKGROUND: Children's oral health and nutrition are interconnected, jointly influencing growth, oral development, and disease prevention such as caries. Despite this connection, they are often addressed separately in research and practice, underscoring the need for validated parental assessment tools that support integrated and interdisciplinary prevention strategies. METHODS: This cross-sectional study examined underlying dietary patterns among 420 children aged 5-12 years in Kaunas, Lithuania, based on parental reports. Data were collected as part of a broader investigation of oral health behavior (OHB) and knowledge. Children's consumption habits were assessed using 17 structured dietary items, which were further used to adapt nutritional assessment subscales. Ethical approval was obtained from Kaunas Kolegija HEI. Exploratory factor analysis (EFA) was conducted to identify underlying dietary dimensions, and associations with sociodemographic variables and OHB were examined using correlation and regression analyses. RESULTS: EFA revealed a three-factor model explaining 40.30% of total variance, comprising: "recommended healthy foods" (e.g., fruits, vegetables), "inappropriate drinks and snacks" (e.g., sugary beverages), and "dairy products." Dietary measures were not associated with parents' age, gender, or self-perceived nutrition knowledge. Parents' education type was positively associated with "dietary" and "recommended healthy foods", while children's age showed negative associations with these variables, indicating less healthy dietary patterns in older children. OHB was positively associated with "recommended healthy foods", "dietary", and fruit and vegetable intake, but negatively associated with inappropriate drinks and snacks. Regression analysis revealed that consumption of "recommended healthy foods" and "parental success in ensuring healthy eating" as significant independent predictors of optimal OHB. CONCLUSIONS: These findings provide empirical support a multidimensional, parent-based dietary assessment framework that captures distinct eating patterns relevant to oral health. Integrating such tools into oral health promotion may enhance early prevention strategies by linking dietary behaviors with oral hygiene practices in a structured and evidence-based manner. CI - (c) 2026 Buunk-Werkhoven, Tamuliene, Dailidaite and Maciuliene. FAU - Buunk-Werkhoven, Yvonne A B AU - Buunk-Werkhoven YAB AD - Faculty of Medicine, Oral Health Department, Kauno Kolegija Higher Education Institution, Kaunas, Lithuania. FAU - Tamuliene, Rasa AU - Tamuliene R AD - Faculty of Medicine, Oral Health Department, Kauno Kolegija Higher Education Institution, Kaunas, Lithuania. FAU - Dailidaite, Evelina AU - Dailidaite E AD - Faculty of Medicine, Department of Medical Technologies and Dietetics, Kauno Kolegija Higher Education Institution, Kaunas, Lithuania. FAU - Maciuliene, Daiva AU - Maciuliene D AD - Faculty of Medicine, Oral Health Department, Kauno Kolegija Higher Education Institution, Kaunas, Lithuania. LA - eng PT - Journal Article DEP - 20260615 PL - Switzerland TA - Front Oral Health JT - Frontiers in oral health JID - 9918227262706676 PMC - PMC13311115 OTO - NOTNLM OT - Lithuania OT - health promotion OT - oral health and consumption habits OT - parental influence OT - pre- and primary school children COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/30 06:31 MHDA- 2026/06/30 06:32 PMCR- 2026/06/15 CRDT- 2026/06/30 05:19 PHST- 2026/03/31 00:00 [received] PHST- 2026/05/06 00:00 [revised] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/06/30 06:32 [medline] PHST- 2026/06/30 06:31 [pubmed] PHST- 2026/06/30 05:19 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.3389/froh.2026.1844389 [doi] PST - epublish SO - Front Oral Health. 2026 Jun 15;7:1844389. doi: 10.3389/froh.2026.1844389. eCollection 2026. PMID- 42375325 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260813 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Development and validation of a clinical prediction model for poor ovarian response in assisted reproductive technology. PG - 1732869 LID - 10.3389/fendo.2026.1732869 [doi] LID - 1732869 AB - OBJECTIVE: The aim of this study was to develop and validate a predictive model for poor ovarian response (POR) in patients undergoing Assisted Reproductive Technology (ART). METHODS: This retrospective cohort study included 1,789 patients who underwent IVF/ICSI with a GnRH antagonist protocol at the reproductive medicine center of Shenyang Women's and Children's Hospital between January 2020 and December 2023. Data from January 2020 to April 2023 were used for model development, and data from May 2023 to December 2023 was used for validation. Clinical and ovarian reserve markers were collected. Four prediction models were developed and compared: (1) logistic regression with stepwise selection, (2) full-variable logistic regression, (3) LASSO regression with the minimum lambda (lambda_min) criterion, and (4) LASSO regression with the 1-standard error (1-SE) rule. The optimal model was selected based on discrimination (area under the receiver operating characteristic curve, AUC), calibration, and Brier score. RESULTS: The final model, based on stepwise logistic regression, identified AMH, basal FSH, BMI, and antral follicle count as significant predictors of POR. The model exhibited high discriminatory ability and good calibration across the training, internal validation, and test datasets. The nomogram developed from this model provides an easy-to-use tool for individualized risk prediction, enabling clinicians to optimize treatment strategies for patients at risk of POR. CONCLUSION: This study provides a comprehensive predictive model for POR in ART, incorporating a wide range of clinical and ovarian reserve markers. The stepwise logistic regression model offers superior predictive accuracy and clinical utility, making it a valuable tool for personalized ART management. The nomogram developed enhances decision-making in ART by offering an intuitive, evidence-based method for predicting POR risk. CI - Copyright (c) 2026 Xin, Cheng, Hu, Guo, Li, Zhao and Guo. FAU - Xin, Xin AU - Xin X AD - Department of Reproductive Medicine, Shenyang Women's and Children's Hospital, Shenyang, Liaoning, China. AD - Liaoning Key Laboratory of Assisted Reproduction, Shenyang, Liaoning, China. AD - Shenyang Clinical Medical Research Center for Assisted Reproduction, Shenyang, Liaoning, China. FAU - Cheng, Zhaoxia AU - Cheng Z AD - Department of Reproductive Medicine, Shenyang Women's and Children's Hospital, Shenyang, Liaoning, China. AD - Liaoning Key Laboratory of Assisted Reproduction, Shenyang, Liaoning, China. AD - Shenyang Clinical Medical Research Center for Assisted Reproduction, Shenyang, Liaoning, China. FAU - Hu, Ting AU - Hu T AD - Department of Reproductive Medicine, Shenyang Women's and Children's Hospital, Shenyang, Liaoning, China. AD - Liaoning Key Laboratory of Assisted Reproduction, Shenyang, Liaoning, China. AD - Shenyang Clinical Medical Research Center for Assisted Reproduction, Shenyang, Liaoning, China. FAU - Guo, Yi AU - Guo Y AD - Department of Reproductive Medicine, Shenyang Women's and Children's Hospital, Shenyang, Liaoning, China. AD - Liaoning Key Laboratory of Assisted Reproduction, Shenyang, Liaoning, China. AD - Shenyang Clinical Medical Research Center for Assisted Reproduction, Shenyang, Liaoning, China. FAU - Li, Nan AU - Li N AD - Department of Reproductive Medicine, Shenyang Women's and Children's Hospital, Shenyang, Liaoning, China. AD - Liaoning Key Laboratory of Assisted Reproduction, Shenyang, Liaoning, China. AD - Shenyang Clinical Medical Research Center for Assisted Reproduction, Shenyang, Liaoning, China. FAU - Zhao, Junbo AU - Zhao J AD - Department of Reproductive Medicine, Shenyang Women's and Children's Hospital, Shenyang, Liaoning, China. AD - Liaoning Key Laboratory of Assisted Reproduction, Shenyang, Liaoning, China. AD - Shenyang Clinical Medical Research Center for Assisted Reproduction, Shenyang, Liaoning, China. FAU - Guo, Shuaishuai AU - Guo S AD - Department of Reproductive Medicine, Shenyang Women's and Children's Hospital, Shenyang, Liaoning, China. AD - Liaoning Key Laboratory of Assisted Reproduction, Shenyang, Liaoning, China. AD - Shenyang Clinical Medical Research Center for Assisted Reproduction, Shenyang, Liaoning, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260615 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 80497-65-0 (Anti-Mullerian Hormone) SB - IM MH - Humans MH - Female MH - Retrospective Studies MH - *Reproductive Techniques, Assisted MH - *Ovarian Reserve/physiology MH - Adult MH - *Ovulation Induction/methods MH - Prediction Algorithms MH - Anti-Mullerian Hormone/blood MH - Logistic Models MH - Nomograms MH - Fertilization in Vitro PMC - PMC13310710 OTO - NOTNLM OT - assisted reproductive technology OT - clinical prediction model OT - nomogram OT - ovarian reserve markers OT - poor ovarian response COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/30 06:31 MHDA- 2026/06/30 06:32 PMCR- 2026/06/15 CRDT- 2026/06/30 05:15 PHST- 2025/10/26 00:00 [received] PHST- 2026/03/18 00:00 [revised] PHST- 2026/03/25 00:00 [accepted] PHST- 2026/06/30 06:32 [medline] PHST- 2026/06/30 06:31 [pubmed] PHST- 2026/06/30 05:15 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.3389/fendo.2026.1732869 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Jun 15;17:1732869. doi: 10.3389/fendo.2026.1732869. eCollection 2026. PMID- 42372031 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261008 IS - 1360-0451 (Electronic) IS - 0954-0121 (Linking) VI - 38 IP - 10 DP - 2026 Oct TI - Self-reported physical activity and associated health factors among individuals attending an urban HIV and sexual health clinic in the UK: a secondary analysis of a clinic-based cross-sectional survey. PG - 2137-2146 LID - 10.1080/09540121.2026.2686237 [doi] AB - Low levels of physical activity are associated with negative health consequences such as metabolic syndrome and depression, particularly among people living with HIV. Contemporary data on physical activity levels among people living with HIV in the United Kingdom are limited. In a cross-sectional survey, 280 respondents' (217 (78%) individuals living with and 62 (22%) without HIV) physical activity was assessed using the validated General Practice Physical Activity Questionnaire (GPPAQ). Socio-demographic characteristics and health factors were collected. A third of the respondents (33.21%) reported being physically active. Living with HIV (OR 0.35 (95%CI 0.19-0.62)), older age (OR 0.97 (95%CI 0.95-0.99)), Black ethnic background (OR 0.33 (95%CI 0.09-1.17)) and smoking (OR 0.55 (95%CI 0.27-1.11)) were associated with lower odds of being physically active in the univariate analyses. Risky alcohol consumption (OR 1.72 (95%CI 0.98-3.08)) and irregular dietary habits (OR 2.09 (95%CI 1.19-3.68)) were associated with being physically active. In the fully adjusted model, only the association between physical activity and HIVstatus persisted. Participants living with HIV were 59% less likely to report being physically active (adjusted OR 0.41, 95% CI 0.21-0.79). The low proportion of reported physical activity suggests a potential role for screening and guidance for exercise among HIV and sexual health clinic attendees. FAU - Bascombe, Florence AU - Bascombe F AUID- ORCID: 0000-0003-1005-6190 AD - Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London, United Kingdom. AD - The Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, United Kingdom. FAU - Mcalpine, Connor AU - Mcalpine C AD - Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London, United Kingdom. AD - The Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, United Kingdom. FAU - Milinkovic, Ana AU - Milinkovic A AD - Chelsea & Westminster Hospital NHS Foundation Trust, London, United Kingdom. FAU - Paredes, Jose Luis AU - Paredes JL AD - Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London, United Kingdom. AD - The Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, United Kingdom. FAU - Matthews, Rebecca AU - Matthews R AD - Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London, United Kingdom. AD - The Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, United Kingdom. FAU - Arenas-Pinto, Alejandro AU - Arenas-Pinto A AUID- ORCID: 0000-0002-3368-5005 AD - Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London, United Kingdom. AD - The Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, United Kingdom. AD - MRC Clinical Trials Unit at UCL, London, United Kingdom. FAU - Suonpera, Emmi AU - Suonpera E AUID- ORCID: 0000-0001-9412-2516 AD - Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London, United Kingdom. AD - The Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, United Kingdom. LA - eng PT - Journal Article DEP - 20260629 PL - England TA - AIDS Care JT - AIDS care JID - 8915313 SB - IM MH - Cross-Sectional Studies MH - *Exercise MH - United Kingdom MH - Self Report MH - Ambulatory Care Facilities/statistics & numerical data MH - *HIV Infections MH - *HIV Long-Term Survivors/statistics & numerical data MH - Surveys and Questionnaires MH - Health Behavior MH - Sexual Health MH - *Urban Health Services/statistics & numerical data MH - Socioeconomic Factors MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged OTO - NOTNLM OT - Cross-sectional OT - HIV OT - Physical activity OT - men who have sex with men OT - mental health EDAT- 2026/06/29 18:43 MHDA- 2026/10/07 17:33 CRDT- 2026/06/29 14:03 PHST- 2026/10/07 17:33 [medline] PHST- 2026/06/29 18:43 [pubmed] PHST- 2026/06/29 14:03 [entrez] AID - 10.1080/09540121.2026.2686237 [doi] PST - ppublish SO - AIDS Care. 2026 Oct;38(10):2137-2146. doi: 10.1080/09540121.2026.2686237. Epub 2026 Jun 29. PMID- 42370796 OWN - NLM STAT- Publisher LR - 20260629 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) DP - 2026 Jun 29 TI - Food insecurity, nutrition, and mental health in children after earthquake exposure: Evidence from Turkiye. PG - 2601060261464033 LID - 10.1177/02601060261464033 [doi] AB - BackgroundChildren are particularly vulnerable to the psychological and nutritional consequences of natural disasters such as earthquakes. Understanding the relationship between mental health outcomes and food insecurity is essential for effective post-disaster interventions.ObjectivesThis study aimed to assess the prevalence of post-traumatic stress disorder (PTSD), anxiety, and depressive symptoms among children exposed to the 2023 earthquake in Turkiye, and to examine their nutritional status and household food security.MethodsA multicenter, cross-sectional survey was conducted between March and August 2025 among 782 children aged 6-17 years from twelve earthquake-affected provinces. Participants were recruited using stratified cluster sampling from schools and community health centers. Psychological outcomes were assessed using validated instruments (CPSS, SCARED, CDI). Nutritional status was evaluated using anthropometric measurements, dietary diversity indicators, and standardized food security scales.ResultsOverall, 21.7% of participants met the CPSS cut-off for probable PTSD, with a higher prevalence among girls. Anxiety symptoms were identified in 25.8% and depressive symptoms in 21.4% of children. Nutritional assessment showed that 11.3% were underweight and 18.6% were overweight or obese. Additionally, 40.3% of households experienced food insecurity.ConclusionMental health problems and nutritional vulnerability frequently co-occur among children after earthquake exposure. Integrated interventions addressing both psychological well-being and food security are essential to support recovery in disaster-affected populations. FAU - Arslan, Nurgul AU - Arslan N AUID- ORCID: 0000-0002-7618-0859 AD - Department of Nutrition and Dietetics, Ataturk Faculty of Health Sciences, Dicle University, Diyarbakir, Turkiye. RINGGOLD: 37507 LA - eng PT - Journal Article DEP - 20260629 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 SB - IM OTO - NOTNLM OT - Earthquakes OT - anxiety OT - children OT - depression OT - food security OT - mental health OT - nutritional status EDAT- 2026/06/29 12:33 MHDA- 2026/06/29 12:33 CRDT- 2026/06/29 09:43 PHST- 2026/06/29 12:33 [medline] PHST- 2026/06/29 12:33 [pubmed] PHST- 2026/06/29 09:43 [entrez] AID - 10.1177/02601060261464033 [doi] PST - aheadofprint SO - Nutr Health. 2026 Jun 29:2601060261464033. doi: 10.1177/02601060261464033. PMID- 42370059 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260629 LR - 20260813 IS - 2753-4294 (Electronic) IS - 2753-4294 (Linking) VI - 4 IP - 2 DP - 2026 TI - Identifying developmental vulnerability through linear growth screening: a UK cross-sectional study. PG - e004567 LID - 10.1136/bmjph-2025-004567 [doi] LID - e004567 AB - INTRODUCTION: Linear growth in early childhood is routinely measured in the UK, but it is unclear whether indicators of linear growth faltering can flag children with neurodevelopmental vulnerability, especially in ethnically diverse urban settings. We tested whether short stature (stunting) or being short for genetic potential identifies children at risk of failing routine developmental screening at age 2-2.5 years. METHODS: We conducted a cross-sectional analysis among 555 children aged 24-30 months (mean 26.0 months, SD 1.5) attending Healthy Child Programme reviews in East London. The sample was ethnically diverse, with substantial proportions of Bangladeshi, White and other minority ethnic groups. Developmental vulnerability was defined as scoring below the Ages and Stages Questionnaire, Third Edition (ASQ-3) cut-off in >/=1 domain. The exposures were stunting (height-for-age z score <-2 SD) and being short for genetic potential, defined as deviation from mid-parental height (DMPH) <-2 SD. Associations were examined using binomial multivariable logistic regression adjusted for age, sex, prematurity, maternal education, ethnicity and household benefits. A subset (n=94) completed the Griffiths III Mental Development Scales (GMDS-III) to validate ASQ-3 classification. RESULTS: Overall, 141/555 (25.4%) children screened positive for developmental vulnerability on the ASQ-3. Children with developmental vulnerability had significantly lower GMDS-III scaled scores across multiple domains supporting criterion validity. We did not find evidence of an association between stunting and developmental vulnerability (adjusted OR 1.35, 95% CI 0.47 to 3.49). In contrast, children who were short for genetic potential (DMPH <-2 SD) had higher odds of developmental vulnerability (adjusted OR 4.18, 95% CI 1.13 to 14.78). CONCLUSIONS: In this urban UK cohort, deviation from genetic height potential, rather than stunting, identified children at increased risk of developmental vulnerability. Incorporating parental heights into routine growth surveillance could offer a simple trigger for earlier neurodevelopmental review. CI - Copyright (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Papasavva, Michael AU - Papasavva M AUID- ORCID: 0000-0003-2111-9783 AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Orr, Joanna AU - Orr J AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Cordani, Isabella AU - Cordani I AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Oloko, Lola AU - Oloko L AD - Tower Hamlets GP Care Group CIC, London, UK. FAU - Hutchinson, Celes AU - Hutchinson C AD - Tower Hamlets GP Care Group CIC, London, UK. FAU - Norton, Christopher AU - Norton C AD - Tower Hamlets GP Care Group CIC, London, UK. FAU - Kamaljit, Kaur AU - Kamaljit K AD - Tower Hamlets GP Care Group CIC, London, UK. FAU - Freer, Joseph AU - Freer J AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Walton, Robert AU - Walton R AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Storr, Helen L AU - Storr HL AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Smuk, Melanie AU - Smuk M AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Prendergast, Andrew J AU - Prendergast AJ AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. LA - eng PT - Journal Article DEP - 20260623 PL - England TA - BMJ Public Health JT - BMJ public health JID - 9918697578906676 PMC - PMC13295896 OTO - NOTNLM OT - Humans OT - Public Health OT - Sociodemographic Factors COIS- None declared. EDAT- 2026/06/29 16:10 MHDA- 2026/06/29 16:11 PMCR- 2026/06/23 CRDT- 2026/06/29 07:03 PHST- 2025/11/19 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/06/29 16:11 [medline] PHST- 2026/06/29 16:10 [pubmed] PHST- 2026/06/29 07:03 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - bmjph-2025-004567 [pii] AID - 10.1136/bmjph-2025-004567 [doi] PST - epublish SO - BMJ Public Health. 2026 Jun 23;4(2):e004567. doi: 10.1136/bmjph-2025-004567. eCollection 2026. PMID- 42369304 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260629 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Mood changes of children and adolescents in dance classes: a prospective repeated-measures study. PG - 1719704 LID - 10.3389/fpsyg.2026.1719704 [doi] LID - 1719704 AB - INTRODUCTION: Adolescent mental health in the United States has deteriorated markedly over the past decade, with diagnosed mental or behavioral health conditions among 12-to-17-year-olds increasing 35% between 2016 and 2023, driven by a 61% rise in anxiety diagnoses and a 45% rise in depression. Community-based interventions combining physical activity, creative expression, and social connection represent a promising response. METHODS: This prospective repeated-measures study examined the association between structured dance education and mood among 256 children and adolescents (ages 5-17) at four studio locations. Over 4 months (February-May 2025), students completed 4,224 paired pre- and post-class mood ratings using a single-item emoji scale; the primary analytic sample comprised 4,059 sessions from 251 students. PANAS-C administrations provided a concurrent measure of dispositional affect, with each student's score anchored to the administration nearest the study close. Multilevel models accounted for the nested data structure (students contributing 1-109 sessions each). RESULTS: The intraclass correlation was 0.432. Post-class mood was significantly higher than pre-class mood (session-level Cohen's d = 0.27 [primary estimate] and per-student d_z = 0.43 [p < 0.001]) with 85.8% of sessions showing maintained or improved mood. A Tobit sensitivity analysis confirmed these patterns after adjusting for the 28.8% post-class ceiling rate. No covariate (including weekly frequency, class type, proficiency level, or instructor experience) explained significant additional variance. Individual differences dominated: random slopes improved model fit substantially (DeltaAIC = 201). Convergent validity between the emoji scale and PANAS-C Positive Affect was significant (r = 0.19, p = 0.011, n = 175), with the strongest association among students attending 4-6 classes per week (r = 0.51, n = 25). CONCLUSION: Dance participation was associated with a consistent acute mood benefit generalizing across genres, schedules, and experience levels; individual characteristics, rather than program features, accounted for most meaningful variation. The observational design precludes causal attribution. CI - Copyright (c) 2026 Henderson, Henderson, Robertson-Kraft and Levick. FAU - Henderson, Tiffany C AU - Henderson TC AD - Master of Applied Positive Psychology Program, University of Pennsylvania, Philadelphia, PA, United States. AD - Tiffany's Dance Academy, Livermore, CA, United States. FAU - Henderson, Paul R AU - Henderson PR AD - Raising the Barre, Livermore, CA, United States. FAU - Robertson-Kraft, Claire AU - Robertson-Kraft C AD - Master of Applied Positive Psychology Program, University of Pennsylvania, Philadelphia, PA, United States. FAU - Levick, Judy Saltzberg AU - Levick JS AD - Master of Applied Positive Psychology Program, University of Pennsylvania, Philadelphia, PA, United States. LA - eng PT - Journal Article DEP - 20260611 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13293843 OTO - NOTNLM OT - PANAS-C OT - children and adolescents OT - dance education OT - ecological momentary assessment OT - mood OT - multilevel modeling OT - positive psychology OT - well-being COIS- TH and PH are co-founders of Tiffany's Dance Academy, a for-profit dance studio business, and Raising the Barre, a 501(c)(3) youth-service nonprofit organization, both based in Livermore, CA, USA. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/29 12:32 MHDA- 2026/06/29 12:33 PMCR- 2026/06/11 CRDT- 2026/06/29 06:56 PHST- 2025/10/06 00:00 [received] PHST- 2026/04/14 00:00 [revised] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/06/29 12:33 [medline] PHST- 2026/06/29 12:32 [pubmed] PHST- 2026/06/29 06:56 [entrez] PHST- 2026/06/11 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1719704 [doi] PST - epublish SO - Front Psychol. 2026 Jun 11;17:1719704. doi: 10.3389/fpsyg.2026.1719704. eCollection 2026. PMID- 42368948 OWN - NLM STAT- MEDLINE DCOM- 20260629 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Formal uniforms as an environmental constraint on NEAT and adolescent obesity: a cross-sectional study in boarding schools. PG - 1817702 LID - 10.3389/fpubh.2026.1817702 [doi] LID - 1817702 AB - BACKGROUND: The rising prevalence of obesity in adolescents is commonly attributed to a decrease in moderate to vigorous physical activity (MVPA), but the role of environmental constraints on thermogenesis from non-exercise activities (NEAT) remains under-explored. School uniforms are a daily necessity and may be associated with physical or perceived barriers to spontaneous low-intensity movement. This study investigated the relationship between type of school uniform (formal versus athletic) and body mass index (BMI) and examined whether NEAT-related behaviors showed a statistical mediation pattern in a gender-specific manner. METHOD: A cross-sectional study was conducted in four 100 percent boarding secondary schools in China. A total of 1,068 adolescents were stratified by mandatory uniform type. NEAT-related behaviors were assessed using an adapted self-reported questionnaire and compared with accelerometry-derived metrics in a sedentary validation sub-sample (n = 108). Mediation analyses and moderated mediation analyses were conducted to examine the uniform type, NEAT-related behaviors, and BMI associations. RESULTS: Formal uniforms were significantly associated with higher BMI in women (Delta = 0.7 kg/m(2), p < 0.01) but not in men (p > 0.05). Mediation analyses suggested that this association was statistically mediated by lower NEAT-related behaviors [beta_indirect = 0.123, 95% CI (0.054, 0.208)], accounting for 60.3% of the total effect. Exploratory subgroup analyses showed a larger uniform-BMI difference among students in the lowest NEAT-related activity decile: in the lowest decile of sedentary behavior, the difference in body mass index between homogeneous groups widened from a negligible amount in highly active girls to a larger observed difference of 1.3 kg/m(2) (p < 0.01). CONCLUSION: Formal school uniforms were associated with lower NEAT-related movement and higher body mass index in adolescent females in this study population. This relationship was more pronounced among students with lower baseline activity levels, suggesting that restrictive clothing may act as an environmental constraint on spontaneous low-intensity movement. These findings suggest that movement-friendly school uniform designs may warrant further investigation in residential school settings. CI - Copyright (c) 2026 Wang, Lin, Zhang and Liu. FAU - Wang, Yuan AU - Wang Y AD - School Uniform Management Professional Committee, China Association for Campus Management, Beijing, China. FAU - Lin, Rubing AU - Lin R AD - Department of Orthopedics, Shenzhen Children's Hospital, Shenzhen, China. FAU - Zhang, Wei AU - Zhang W AD - Department of Clinical Laboratory, Peking University Shenzhen Hospital, Shenzhen, China. FAU - Liu, Yantong AU - Liu Y AD - Department of Clinical Laboratory, Peking University Shenzhen Hospital, Shenzhen, China. AD - Department of Computer and Information Engineering, Kunsan National University, Gunsan, Republic of Korea. LA - eng PT - Journal Article DEP - 20260612 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Female MH - Adolescent MH - Body Mass Index MH - China/epidemiology MH - *Schools MH - *Pediatric Obesity/epidemiology MH - *Clothing/statistics & numerical data MH - *Thermogenesis/physiology MH - *Exercise/physiology MH - Accelerometry PMC - PMC13303609 OTO - NOTNLM OT - adolescent obesity OT - environmental constraint OT - gender disparity OT - non-exercise activity thermogenesis (NEAT) OT - school uniforms OT - sedentary behavior COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/29 16:10 MHDA- 2026/06/29 16:11 PMCR- 2026/06/12 CRDT- 2026/06/29 06:52 PHST- 2026/02/25 00:00 [received] PHST- 2026/05/04 00:00 [revised] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/06/29 16:11 [medline] PHST- 2026/06/29 16:10 [pubmed] PHST- 2026/06/29 06:52 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1817702 [doi] PST - epublish SO - Front Public Health. 2026 Jun 12;14:1817702. doi: 10.3389/fpubh.2026.1817702. eCollection 2026. PMID- 42368298 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260629 LR - 20260926 IS - 1687-8728 (Print) IS - 1687-8736 (Electronic) IS - 1687-8728 (Linking) VI - 2026 DP - 2026 TI - Morphological Study of the Characteristics of Lips in Children With Mouth Breathing. PG - 1585193 LID - 10.1155/ijod/1585193 [doi] LID - 1585193 AB - OBJECTIVE: This study aimed to explore the association between long-term mouth breathing habits and the morphological characteristics of children's lips, providing a basis for clinical diagnosis and early intervention. Given the cross-sectional design and reliance on parental questionnaire-based exposure classification, causal inference is not warranted; findings are strictly associative. METHODS: A total of 210 children aged 6-12 years were enrolled, comprising 105 children clinically classified as long-term mouth-breathing children and 105 nasal-breathing children. Classification was based on a validated parental questionnaire with defined major and minor signs; objective airway assessment was not performed, which is acknowledged as a limitation. Lip morphological characteristics were analyzed from standardized lateral cephalograms. Quantitative parameters included protrusion of the subnasal region, upper lip, lower lip, and chin; length of the upper lip, lower lip, and chin; the ratio of upper lip length to lower lip length; nasolabial angle; mentolabial angle. Comparisons between groups used independent-samples t-tests with covariate adjustment (analysis of covariance [ANCOVA]) for age, sex, and BMI, and the Benjamini-Hochberg false discovery rate (FDR) correction for multiple comparisons. Effect sizes (Cohen's d) and 95% confidence intervals (CIs) are reported. RESULTS: Significant positive correlations were found among Ns to N' Vert, UL to N' Vert, LL to N' Vert, Pog' to N' Vert, UL-L, LL-L, and Cn-L. Compared with nasal-breathing children, mouth-breathing children showed decreased protrusion of the subnasal region and upper lip, retraction of the chin, a sharper nasolabial angle, and a more obtuse mentolabial angle. No significant difference in lower lip protrusion (LL to N' Vert) was found between groups (adjusted p = 0.225). Because all participants were recruited from an orthodontic clinic, these findings may not be generalizable to the general pediatric population. CONCLUSIONS: Mouth breathing is associated with significant differences in lip and facial soft-tissue morphology in children, particularly in the protrusion and length of the subnasal region, upper lip, and chin, as well as in nasolabial and mentolabial angles. Early identification and interdisciplinary management of mouth breathing may be important for preventing further morphological changes; however, longitudinal studies are needed to establish temporal relationships and causal mechanisms. CI - Copyright (c) 2026 Lu Wenting et al. International Journal of Dentistry published by John Wiley & Sons Ltd. FAU - Wenting, Lu AU - Wenting L AUID- ORCID: 0009-0000-3613-0550 AD - Department of Orthodontics, Shanghai Ninth Peoples' Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China, shsmu.edu.cn. FAU - Xiaowei, Wu AU - Xiaowei W AUID- ORCID: 0009-0000-7248-839X AD - Department of Orthodontics, Shanghai Ninth Peoples' Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China, shsmu.edu.cn. FAU - Shengdan, Yu AU - Shengdan Y AD - Department of Orthodontics, Shanghai Ninth Peoples' Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China, shsmu.edu.cn. FAU - Xin, Yan AU - Xin Y AD - Department of Orthodontics, Shanghai Ninth Peoples' Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China, shsmu.edu.cn. FAU - Mengyuan, Guo AU - Mengyuan G AD - Department of Orthodontics, Shanghai Ninth Peoples' Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China, shsmu.edu.cn. FAU - Lili, Hou AU - Lili H AUID- ORCID: 0000-0001-6489-1744 AD - Department of Nursing, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China, shsmu.edu.cn. FAU - Xiaogang, Pan AU - Xiaogang P AUID- ORCID: 0000-0001-8623-4526 AD - Department of Orthodontics, Shanghai Ninth Peoples' Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China, shsmu.edu.cn. LA - eng PT - Journal Article DEP - 20260626 PL - United States TA - Int J Dent JT - International journal of dentistry JID - 101524183 EIN - Int J Dent. 2026 Aug 11;2026:9769151. doi: 10.1155/ijod/9769151. PMID: 42591848 PMC - PMC13306110 OTO - NOTNLM OT - children OT - early intervention OT - lip morphological characteristics OT - mouth breathing COIS- The authors declare no conflicts of interest. EDAT- 2026/06/29 12:32 MHDA- 2026/06/29 12:33 PMCR- 2026/06/26 CRDT- 2026/06/29 06:46 PHST- 2025/05/20 00:00 [received] PHST- 2026/04/28 00:00 [revised] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/06/29 12:33 [medline] PHST- 2026/06/29 12:32 [pubmed] PHST- 2026/06/29 06:46 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - IJOD1585193 [pii] AID - 10.1155/ijod/1585193 [doi] PST - epublish SO - Int J Dent. 2026 Jun 26;2026:1585193. doi: 10.1155/ijod/1585193. eCollection 2026. PMID- 42365611 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260706 IS - 1471-2865 (Electronic) IS - 1358-2267 (Linking) VI - 31 IP - 3 DP - 2026 Jul TI - Reliability of Pressure Pain Threshold Measurements of Upper and Lower Limb Muscles of Young Swimmers: An Observational Study. PG - e70262 LID - 10.1002/pri.70262 [doi] AB - BACKGROUND AND PURPOSE: Objective measures should be combined with subjective assessments to monitor pain and discomfort, particularly in sports with a high prevalence of atraumatic injuries. Therefore, this study aimed to determine the reliability of pressure pain threshold (PPT) measurements in competitive swimmers and to explore the influence of intrinsic and extrinsic factors on PPT. METHODS: Forty-seven swimmers were included in the study. PPT was measured bilaterally in 10 muscles of the upper and lower limbs and trunk using a hand-held algometer. Two trained physiotherapists performed four consecutive evaluations on the same day, with a 5-min interval between repeated measures, in randomized order to minimize carryover effects. Intrinsic variables included age, body mass index, shoulder pain, injury history, and years of practice. Extrinsic variables included swimming style, swimming distance, competitive level, training frequency, and training duration. Reliability was assessed using intraclass correlation coefficients, standard error of measurement, minimal detectable change, and coefficient of variation. The influence of intrinsic and extrinsic factors on PPT was explored using multivariate analysis of variance. RESULTS: Reliability varied from good to excellent across all muscles, with ICC values between 0.75 and 0.95. Descriptive data indicated that swimmers competing at the national level had higher PPT values compared with regional/state athletes, and butterfly specialists showed slightly higher PPTs. Across all participants, lower limb muscles consistently exhibited higher PPT values than upper limb muscles (e.g., rectus femoris mean 4.2 kg/cm(2) vs. biceps brachii mean 2.8 kg/cm(2)). CONCLUSIONS: Reliability was high across all muscles, and PPT differences observed appear to reflect training level, stroke specialization, and muscle group characteristics rather than intrinsic or injury-related factors. Furthermore, applications up to 5 kgf are safe and well tolerated in the lower limb, which differs from the usual threshold of 2.55 kgf commonly used in the upper limb. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Carrion Caldeira Ribeiro, Gabriela AU - Carrion Caldeira Ribeiro G AUID- ORCID: 0000-0002-5952-7603 AD - Department of Physiotherapy, Sao Paulo State University, Sao Paulo, Brazil. FAU - Alves de Carvalho, Flavia AU - Alves de Carvalho F AUID- ORCID: 0000-0002-2740-4959 AD - Department of Physiotherapy, Sao Paulo State University, Sao Paulo, Brazil. FAU - Paes de Lima, Heloisa AU - Paes de Lima H AUID- ORCID: 0000-0002-1460-0141 AD - Department of Physiotherapy, Sao Paulo State University, Sao Paulo, Brazil. FAU - Moreira de Castro Pereira Perez Espinoza, Rafael AU - Moreira de Castro Pereira Perez Espinoza R AUID- ORCID: 0000-0002-8167-7448 AD - Department of Physiotherapy, Sao Paulo State University, Sao Paulo, Brazil. FAU - Machado da Silva, Isaque AU - Machado da Silva I AUID- ORCID: 0009-0002-8339-7287 AD - Department of Physiotherapy, Sao Paulo State University, Sao Paulo, Brazil. FAU - Zacharias de Souza, Ricardo AU - Zacharias de Souza R AUID- ORCID: 0009-0003-6411-017X AD - Department of Physiotherapy, Sao Paulo State University, Sao Paulo, Brazil. FAU - Pastre, Carlos Marcelo AU - Pastre CM AUID- ORCID: 0000-0002-0213-6679 AD - Department of Physiotherapy, Sao Paulo State University, Sao Paulo, Brazil. LA - eng GR - 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ PT - Journal Article PT - Observational Study PL - United States TA - Physiother Res Int JT - Physiotherapy research international : the journal for researchers and clinicians in physical therapy JID - 9612022 SB - IM MH - Humans MH - *Swimming/physiology MH - Female MH - Reproducibility of Results MH - Male MH - *Pain Threshold/physiology MH - Adolescent MH - *Upper Extremity/physiology/physiopathology MH - *Pain Measurement/methods MH - *Lower Extremity/physiology MH - *Muscle, Skeletal/physiopathology MH - Pressure OTO - NOTNLM OT - muscle sensitivity OT - pressure algometry OT - swimmer EDAT- 2026/06/28 18:30 MHDA- 2026/06/28 18:31 CRDT- 2026/06/28 13:22 PHST- 2026/06/09 00:00 [revised] PHST- 2024/11/06 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/06/28 18:31 [medline] PHST- 2026/06/28 18:30 [pubmed] PHST- 2026/06/28 13:22 [entrez] AID - 10.1002/pri.70262 [doi] PST - ppublish SO - Physiother Res Int. 2026 Jul;31(3):e70262. doi: 10.1002/pri.70262. PMID- 42365345 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260915 LR - 20260917 IS - 1477-9560 (Print) IS - 1477-9560 (Electronic) IS - 1477-9560 (Linking) VI - 24 IP - 1 DP - 2026 Jun 27 TI - Association between D-dimer difference and risk of postoperative venous thromboembolism in endometrial cancer: a retrospective cohort study. LID - 10.1186/s12959-026-00893-2 [doi] LID - 84 AB - OBJECTIVE: To investigate the association between D-dimer level changes and venous thromboembolism (VTE) risk in endometrial cancer patients undergoing surgery. METHODS: This retrospective cohort study included 307 endometrial cancer patients who underwent surgical treatment at Fujian Maternity and Child Health Hospital between January 2022 and December 2024, with follow-up to December 2025. D-dimer change was the exposure variable and VTE occurrence the outcome. Multivariable logistic regression assessed independent effects after adjusting for 17 covariates, including age, body mass index, FIGO stage, and comorbidities. Threshold effect and stratified analyses were conducted. RESULTS: Each one-unit increase in D-dimer change was significantly associated with higher VTE risk (adjusted OR = 1.202; 95% CI: 1.076-1.342; P = 0.001). Nonlinear testing revealed a significant threshold effect (P < 0.001) at 3.78: below this threshold, VTE risk increased sharply (OR = 7.761; 95% CI: 4.286-14.051); above it, risk declined (OR = 0.643; 95% CI: 0.526-0.785). Mediation analysis showed anticoagulant therapy, infection, and caprinin had negligible mediating effects (proportion < 0.2%; P > 0.86). CONCLUSION: D-dimer level changes exhibit a nonlinear association with postoperative VTE risk, characterized by a distinct threshold effect. These hypothesis-generating findings suggest that monitoring D-dimer trajectories rather than absolute values may offer a novel dimension for perioperative VTE risk stratification, warranting prospective validation in multicenter cohorts before clinical application. CI - (c) 2026. The Author(s). FAU - Li, Weipeng AU - Li W AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350001, China. FAU - Zheng, Hui AU - Zheng H AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350001, China. FAU - Zhen, Lan AU - Zhen L AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350001, China. FAU - Qiu, Qian AU - Qiu Q AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350001, China. FAU - Zhu, Leilei AU - Zhu L AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350001, China. FAU - Zhang, Rong AU - Zhang R AD - Department of Vascular Surgery & Interventional Therapy, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350001, China. FAU - Yi, Huan AU - Yi H AUID- ORCID: 0009-0009-9209-916X AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350001, China. yi.huan@fjmu.edu.cn. LA - eng GR - No.2025Y9627/the Joint Funds for the Innovation of Science and Technology,Fujian Province/ PT - Journal Article DEP - 20260627 PL - England TA - Thromb J JT - Thrombosis journal JID - 101170542 PMC - PMC13576260 OTO - NOTNLM OT - D-dimer OT - Endometrial cancer OT - Postoperative complications OT - Threshold effect OT - Venous thromboembolism COIS- Declarations. Ethical approval: This study was approved by the Ethics Committee of Fujian Provincial Maternal and Child Health Hospital and strictly adhered to the tenets of the Declaration of Helsinki (IRB: No. 2025KY115). Consent for publication: Not applicable. As this study was a retrospective analysis of de-identified data and the requirement for informed consent was waived by the institutional ethics committee, specific consent for publication was not required. Competing interests: The authors declare no competing interests. EDAT- 2026/06/28 04:09 MHDA- 2026/06/28 04:10 PMCR- 2026/06/27 CRDT- 2026/06/27 23:26 PHST- 2026/02/23 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/06/28 04:10 [medline] PHST- 2026/06/28 04:09 [pubmed] PHST- 2026/06/27 23:26 [entrez] PHST- 2026/06/27 00:00 [pmc-release] AID - 10.1186/s12959-026-00893-2 [pii] AID - 893 [pii] AID - 10.1186/s12959-026-00893-2 [doi] PST - epublish SO - Thromb J. 2026 Jun 27;24(1):84. doi: 10.1186/s12959-026-00893-2. PMID- 42365173 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20261008 IS - 1476-5640 (Electronic) IS - 0954-3007 (Linking) VI - 80 IP - 9 DP - 2026 Sep TI - Evaluation of a context-specific diet diversity score (DDS) for predicting micronutrient adequacy in 6-10-year-old rural Indian children. PG - 919-927 LID - 10.1038/s41430-026-01779-2 [doi] AB - BACKGROUND: Low diet diversity is the major contributor to micronutrient inadequacy among children, underscoring a need for a rapid assessment tool to assess micronutrient adequacy. OBJECTIVE: This study aimed to (i) develop a context-specific diet diversity score (DDS) tool (ii) evaluate the performance of the DDS scoring system against mean probability of adequacy for 10 micronutrients, 5 biomarkers of micronutrient status and (iii) identify an optimal DDS cut-off by applying minimum portion size threshold to support its potential use as a practical screening tool. METHODS: A cross-sectional study was conducted among 6-10-year-old children (n = 76) in two villages of Ghatkesar sub-district, Telangana. Portion sizes of commonly consumed fruits and vegetables were standardized. Data on household demographics, anthropometry, and biomarkers of micronutrient status were collected using a pretested questionnaire and standardized protocols. Three non-consecutive 24-hour-dietary-recalls were obtained using the weighment method. DDS was developed based on the nutrient content of consumed foods; minimum intake thresholds of 0.1 g, 5 g and 10 g was applied while scoring. Mean probability of adequacy (MPA) for 10 micronutrients was estimated using ICMR-EAR values. Correlations of DDS with MPA and biomarkers were examined, and sensitivity and specificity were assessed using ROC curves, considering MPA >/= 70% as adequate. RESULTS: The DDS included 13 food groups. Mean DDS (5 g threshold) was 8.67 +/- 1.50 and correlated significantly with MPA (r = 0.58), and hemoglobin (t = 2.07). A DDS-5 g cut-off of >/=10 predicted MPA > 70%, with an AUC of 0.89. CONCLUSION: The DDS showed good predictive performance for micronutrient adequacy, but requires further field validation before programmatic use. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Konapur, Archana AU - Konapur A AD - Nutrition Information Communication and Health Education (NICHE) Division, ICMR-National Institute of Nutrition, Hyderabad, Telangana State, India. FAU - Krishnapillai, Madhavan Nair AU - Krishnapillai MN AD - Independent Researcher; Formerly, Micronutrient Research Group, ICMR-National Institute of Nutrition, Hyderabad, Telangana State, India. FAU - Kulkarni, Bharati AU - Kulkarni B AD - Director, ICMR-National Institute of Nutrition, Hyderabad, Telangana State, India. FAU - Nagalla, Balakrishna AU - Nagalla B AUID- ORCID: 0000-0002-5613-0942 AD - Department of Statistics, Apollo Hospitals Educational & Research Foundation, Hyderabad, Telangana State, India. FAU - Gavaravarapu, SubbaRao M AU - Gavaravarapu SM AUID- ORCID: 0000-0003-4524-9646 AD - Nutrition Information Communication and Health Education (NICHE) Division, ICMR-National Institute of Nutrition, Hyderabad, Telangana State, India. Subbarao.gm@icmr.gov.in. AD - Faculty of Medical Science, Academy for Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, India. Subbarao.gm@icmr.gov.in. LA - eng GR - 5/9/1138/2014-NUT/Indian Council of Medical Research (ICMR)/ PT - Journal Article DEP - 20260627 PL - England TA - Eur J Clin Nutr JT - European journal of clinical nutrition JID - 8804070 RN - 0 (Micronutrients) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Micronutrients/administration & dosage/deficiency/blood MH - Child MH - Cross-Sectional Studies MH - India MH - Female MH - *Diet MH - Rural Population MH - *Nutrition Assessment MH - Male MH - Nutritional Status MH - Biomarkers/blood MH - Surveys and Questionnaires MH - Vegetables MH - Fruit MH - ROC Curve MH - Sensitivity and Specificity COIS- Competing interests: The authors declare no competing interests. Ethical approval: The study was approved by the Institutional Ethics Committee (IEC) of ICMR-National Institute of Nutrition, Hyderabad, Telangana State, India (08/I/2014 & CR03/II/2016 (revised)); all methods were performed in accordance with the institutional guidelines and regulations. Written informed consent was obtained from all the participants before initiation of data collection. EDAT- 2026/06/28 00:38 MHDA- 2026/09/10 05:37 CRDT- 2026/06/27 23:19 PHST- 2025/10/23 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/05/25 00:00 [revised] PHST- 2026/09/10 05:37 [medline] PHST- 2026/06/28 00:38 [pubmed] PHST- 2026/06/27 23:19 [entrez] AID - 10.1038/s41430-026-01779-2 [pii] AID - 10.1038/s41430-026-01779-2 [doi] PST - ppublish SO - Eur J Clin Nutr. 2026 Sep;80(9):919-927. doi: 10.1038/s41430-026-01779-2. Epub 2026 Jun 27. PMID- 42365169 OWN - NLM STAT- Publisher LR - 20260627 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Jun 27 TI - Diet, lifestyle, metabolic markers, and socioeconomic status are associated with cognitive function in school-aged children from a population-based cohort. LID - 10.1038/s41390-026-05250-7 [doi] AB - BACKGROUND: Cognitive development is associated with diet, activity, sleep, metabolic health, and socioeconomic status. However, evidence remains limited, as most studies have focused on clinical groups or single factors. We examined the combined associations of these variables with cognitive function in school-aged children from the general population. METHODS: We evaluated 170 school-aged children from a population-based cohort (mean age 6.33 +/- 0.03 years; 49% female). Children were evaluated after an overnight fast (>8 h), and anthropometric, metabolic, and socioeconomic variables were evaluated. Diet and physical activity were assessed using validated questionnaires (Vioque FFQ and enKid). Cognitive function was assessed using NEPSY-II and TONI-2 subsets. Correlation and regression analyses were performed. RESULTS: Cognitive function was positively associated with Mediterranean diet adherence, sleep duration, socioeconomic status, and negatively associated with ultra-processed food intake, TV viewing, and metabolic markers including insulin resistance (HOMA-IR), C-reactive protein, and gamma-glutamyltransferase (all p < 0.05). Multivariate analyses showed that Mediterranean diet adherence (OR 2.18, 95%CI 1.08-4.40), economic status (OR 2.50, 95%CI 1.13-5.49), sleep duration (OR 2.90, 95%CI 1.42-5.92), and HOMA-IR (OR 0.47, 95%CI 0.23-0.96) as independently associated with cognitive outcomes, particularly in attention, language, and memory. CONCLUSIONS: Lifestyle factors and socioeconomic conditions are independently associated with cognitive function in children. IMPACT: Key message: Diet, sleep, metabolic health, and socioeconomic status are associated with cognitive function in school-aged children. Novelty: Simultaneously examines multiple factors associated with cognition in school-aged children from a population-based cohort. Impact on cognition: Mediterranean diet adherence, sleep duration, and metabolic health were positively associated with several cognitive domains, including attention, language, and memory. Practical use: Highlights the potential relevance of healthy lifestyles and social equity in relation to cognitive development. Broader significance: Highlights the multifactorial nature of cognitive development in children. CI - (c) 2026. The Author(s). FAU - Gomez-Vilarrubla, Ariadna AU - Gomez-Vilarrubla A AUID- ORCID: 0000-0001-8183-5218 AD - Maternal-Fetal Metabolic Research Group, Girona Institute for Biomedical Research (IDIBGI), Salt, Spain. FAU - Sanchez-Fernandez, Mario AU - Sanchez-Fernandez M AUID- ORCID: 0009-0009-7616-8559 AD - Department of Pediatrics, Dr. Josep Trueta Hospital, Girona, Spain. FAU - Puerto-Carranza, Elsa AU - Puerto-Carranza E AUID- ORCID: 0000-0003-3478-5072 AD - Department of Pediatrics, Dr. Josep Trueta Hospital, Girona, Spain. FAU - Martinez-Calcerrada, Jose-Maria AU - Martinez-Calcerrada JM AUID- ORCID: 0000-0002-4021-2513 AD - Maternal-Fetal Metabolic Research Group, Girona Institute for Biomedical Research (IDIBGI), Salt, Spain. FAU - Mas-Pares, Berta AU - Mas-Pares B AUID- ORCID: 0000-0001-8283-3089 AD - Pediatric Endocrinology Research Group, Girona Institute for Biomedical Research (IDIBGI), Salt, Spain. FAU - Rivero-Martin, Maria-Jose AU - Rivero-Martin MJ AUID- ORCID: 0000-0003-2186-0475 AD - Department of Pediatrics, Hospital Universitario de Fuenlabrada, Madrid, Spain. FAU - Nso-Roca, Ana-Pilar AU - Nso-Roca AP AUID- ORCID: 0000-0002-0601-0213 AD - Department of Pediatrics, Hospital Universitario San Juan de Alicante, San Juan de Alicante, Spain. FAU - Alvarez-Monell, Adam AU - Alvarez-Monell A AUID- ORCID: 0000-0003-4806-3361 AD - Department of Psychiatry and Forensic Medicine, Neuroscience Institute, Universitat Autonoma de Barcelona (INc-UAB), Barcelona, Spain. FAU - Contreras-Rodriguez, Oren AU - Contreras-Rodriguez O AUID- ORCID: 0000-0001-8922-8084 AD - Department of Psychiatry and Forensic Medicine, Neuroscience Institute, Universitat Autonoma de Barcelona (INc-UAB), Barcelona, Spain. AD - CIBER Mental Health (CIBERSAM), Carlos III Health Institute, Madrid, Spain. FAU - Garre-Olmo, Josep AU - Garre-Olmo J AUID- ORCID: 0000-0002-7817-0814 AD - Department of Medical Sciences, University of Girona, Girona, Spain. FAU - Lopez-Bermejo, Abel AU - Lopez-Bermejo A AUID- ORCID: 0000-0002-5828-8911 AD - Department of Pediatrics, Dr. Josep Trueta Hospital, Girona, Spain. alopezbermejo@idibgi.org. AD - Pediatric Endocrinology Research Group, Girona Institute for Biomedical Research (IDIBGI), Salt, Spain. alopezbermejo@idibgi.org. AD - Department of Medical Sciences, University of Girona, Girona, Spain. alopezbermejo@idibgi.org. FAU - Bassols, Judit AU - Bassols J AUID- ORCID: 0000-0001-8821-6655 AD - Maternal-Fetal Metabolic Research Group, Girona Institute for Biomedical Research (IDIBGI), Salt, Spain. jbassols@idibgi.org. LA - eng PT - Journal Article DEP - 20260627 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Patient consent: Written informed consent was obtained from the parents or legal guardians of all participating children prior to enrolment in the study. EDAT- 2026/06/28 00:37 MHDA- 2026/06/28 00:37 CRDT- 2026/06/27 23:19 PHST- 2025/10/28 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/05/28 00:00 [revised] PHST- 2026/06/28 00:37 [medline] PHST- 2026/06/28 00:37 [pubmed] PHST- 2026/06/27 23:19 [entrez] AID - 10.1038/s41390-026-05250-7 [pii] AID - 10.1038/s41390-026-05250-7 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Jun 27. doi: 10.1038/s41390-026-05250-7. PMID- 42365081 OWN - NLM STAT- Publisher LR - 20260627 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) DP - 2026 Jun 27 TI - Predicting children's undernutrition and its association with women's asset ownership in Ethiopia: spatial machine learning. LID - 10.1038/s41598-026-59905-w [doi] AB - Child undernutrition remains a critical public health concern, with prominent geographic and structural disparities in Ethiopia. Understanding how women's asset share and spatial context interact to affect nutritional risk is vital for effective interventions. This study investigates the spatial patterns of child undernutrition, its association with women's asset ownership and other covariates, and the predictive performance of spatial machine learning techniques in making predictions. Using the nationally representative ESPS 2021/22 for model development and internal validation through spatial cross-validation with a 70/30 split, alongside temporal validation employing ESPS I, 2018/19. The metrics were used to compare four machine learning algorithms (random forest, gradient-boosted trees, support vector machines, and geographical random forests) with spatial features to a spatial generalized linear mixed model. The semivariogram result showed a strong spatial dependence, which supported the use of spatial modeling. The women's asset ownership index, children's age, distance to nearest market, mothers' age, distance to nearest road, household size, child sex, region, toilet type, mother's religion, source of drinking water, and place of residence were significant factors. The results demonstrate a distinct inverse spatial correlation between women's asset ownership and child undernutrition, suggesting that women's economic empowerment functions as a protective structural part. The result of temporal validation showed a growing impact of geographic and contextual factors. Gradient-boosted trees and random forests with spatial features make it easy to model intricate nutritional outcomes in different settings. The results underline geographically targeted child nutrition programs and policies that bolster women's economic autonomy and resilience. Integrating spatial analytics and Gradient-boosted trees and random forests machine learning techniques with gender‑sensitive socioeconomic factors can strengthen precise public health strategies to reduce child undernutrition. CI - (c) 2026. The Author(s). FAU - Dessie, Dereje Bekele AU - Dessie DB AD - Department of Statistics, College of Natural and Computational Science, Madda Walabu University, Bale Robe, Ethiopia. derejebekele@hu.edu.et. AD - Department of Statistics, College of Natural and Computational Science, Hawassa University, Hawassa, Ethiopia. derejebekele@hu.edu.et. FAU - Kitawa, Yonas Shuke AU - Kitawa YS AD - Department of Statistics, College of Natural and Computational Science, Hawassa University, Hawassa, Ethiopia. FAU - Asfaw, Zeytu Gashaw AU - Asfaw ZG AD - Department of Epidemiology and Biostatistics, School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia. LA - eng PT - Journal Article DEP - 20260627 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM OTO - NOTNLM OT - Assets OT - Children OT - Machine learning OT - Undernutrition OT - Women COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: The data were obtained via online registration and downloaded after the purpose of the analysis was communicated and approved. An approval for the use of the ESPS data set was gained from the World Bank Microdata Catalog: https://microdata.worldbank.org/collections/lsms. Ethics approval and participants' consent were not required, as this is publicly available data. EDAT- 2026/06/28 00:36 MHDA- 2026/06/28 00:36 CRDT- 2026/06/27 23:17 PHST- 2026/03/20 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/06/28 00:36 [medline] PHST- 2026/06/28 00:36 [pubmed] PHST- 2026/06/27 23:17 [entrez] AID - 10.1038/s41598-026-59905-w [pii] AID - 10.1038/s41598-026-59905-w [doi] PST - aheadofprint SO - Sci Rep. 2026 Jun 27. doi: 10.1038/s41598-026-59905-w. PMID- 42364371 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260911 IS - 1476-5616 (Electronic) IS - 0033-3506 (Linking) VI - 258 DP - 2026 Sep TI - Age-dependent performance of obesity measures in screening for cardiometabolic risk over the lifespan. PG - 106399 LID - S0033-3506(26)00268-4 [pii] LID - 10.1016/j.puhe.2026.106399 [doi] AB - OBJECTIVES: To evaluate age-specific associations of body mass index (BMI) and waist-to-height ratio (WHtR) with cardiometabolic risk and to explore potential age- and sex-specific screening thresholds. STUDY DESIGN: This cross-sectional study included 58,712 participants from the NHANES in the United States from 1999 to 2020. METHODS: Using data from 58,712 participants (aged 12-85 years) from NHANES 1999-2020, we analyzed age-stratified associations between obesity metrics (BMI, WHtR) and cardiometabolic risk (hypertension, dyslipidemia, diabetes). We used subsample population weights to produce estimates representative of the U.S. POPULATION: Covariates included demographics, lifestyle, socioeconomic factors, and medication use. Logistic regression, receiver operating characteristic (ROC) curves, and population attributable fraction were used. Exploratory age- and sex-specific screening thresholds were estimated using Youden's index. RESULTS: ROC analysis suggested that the discriminative performance of both BMI and WHtR for identifying prevalent cardiometabolic risk decreased with increasing age. The association between adiposity measures and prevalent cardiometabolic risk appeared to attenuate with age, as reflected by lower odds ratios and population attributable fractions. Nonlinear, J-shaped cross-sectional associations of BMI and WHtR with cardiometabolic risk were observed, particularly among older adults, in whom the risk appeared to plateau at higher adiposity levels. The screening performance of conventional obesity thresholds varied across age groups. The exploratory age- and sex-specific thresholds based on the maximum Youden index showed relatively balanced sensitivity and specificity, but require prospective validation. CONCLUSIONS: BMI and WHtR exhibited nonlinear associations with cardiometabolic risk. The strength of these associations and their discriminative performance appeared to decrease with age, suggesting that age- and sex-specific screening thresholds may warrant further investigation. CI - Copyright (c) 2026 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved. FAU - Xue, Yongxi AU - Xue Y AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Qi, Qianjin AU - Qi Q AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Gao, Chaonan AU - Gao C AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Meng, Xin AU - Meng X AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Liu, Wei AU - Liu W AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Yan, Yinkun AU - Yan Y AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. Electronic address: ykyan2011@163.com. LA - eng PT - Journal Article DEP - 20260627 PL - Netherlands TA - Public Health JT - Public health JID - 0376507 SB - IM MH - Humans MH - Male MH - Female MH - Middle Aged MH - Cross-Sectional Studies MH - Aged MH - *Obesity/epidemiology/diagnosis MH - Adult MH - Adolescent MH - Body Mass Index MH - Aged, 80 and over MH - United States/epidemiology MH - Young Adult MH - *Cardiometabolic Risk Factors MH - Waist-Height Ratio MH - Nutrition Surveys MH - Child MH - Age Factors MH - *Cardiovascular Diseases/epidemiology MH - *Mass Screening OTO - NOTNLM OT - BMI OT - Cardiometabolic risk OT - Life-course epidemiology OT - Obesity OT - Waist-to-height ratio COIS- Declaration of competing interests The authors declared no conflict of interest. EDAT- 2026/06/28 04:09 MHDA- 2026/09/11 23:36 CRDT- 2026/06/27 18:04 PHST- 2025/11/02 00:00 [received] PHST- 2026/05/15 00:00 [revised] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/09/11 23:36 [medline] PHST- 2026/06/28 04:09 [pubmed] PHST- 2026/06/27 18:04 [entrez] AID - S0033-3506(26)00268-4 [pii] AID - 10.1016/j.puhe.2026.106399 [doi] PST - ppublish SO - Public Health. 2026 Sep;258:106399. doi: 10.1016/j.puhe.2026.106399. Epub 2026 Jun 27. PMID- 42363543 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260916 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 26 DP - 2026 Jun 26 TI - Serum total bilirubin and childhood asthma: Results of the NHANES 2007-2018 and Mendelian randomization study. PG - e49528 LID - 10.1097/MD.0000000000049528 [doi] LID - e49528 AB - Total bilirubin possesses antioxidant and immunomodulatory properties, and its role in childhood asthma is a topic of ongoing debate. We employed both a cross-sectional study and Mendelian randomization (MR) analysis to explore the link between serum total bilirubin and childhood asthma. In the cross-sectional study from the National Health and Nutrition Examination Survey 2007 to 2018, weighted logistic regression models were utilized to investigate the association between serum total bilirubin and childhood asthma. We also used restricted cubic splines to explore the dose-response relationship between the 2. The inverse-variance weighted method was used as the main method of MR analysis to explore the causal effect of exposure on outcomes. A total of 3238 participants were included in the cross-sectional study. Weighted logistic regression analysis encompassing all participants revealed no significant association between total bilirubin levels and the risk of childhood asthma (P > .05). The same results were obtained after categorizing participants into tertiles based on total bilirubin levels. The restricted cubic splines curve revealed an S-shaped relationship between total bilirubin levels and childhood asthma. MR analysis reveals no causal association between serum total bilirubin and childhood asthma (odds ratio [OR] = 0.974, P = .752), peak expiratory flow (OR = 1.002, P = .831), and forced expiratory volume in 1-second (OR = 1.005, P = .554). Our study did not support a causal relationship between serum total bilirubin and childhood asthma. Further studies with a larger number of cases are crucial to validate our findings. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - He, Lijun AU - He L AD - Department of Ultrasound, The Second Affiliated Hospital of Army Medical University, Chongqing, China. FAU - Wang, Kang AU - Wang K AUID- ORCID: 0000-0002-0967-3872 AD - Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Army Medical University, Chongqing, China. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R RN - RFM9X3LJ49 (Bilirubin) SB - IM MH - Humans MH - *Bilirubin/blood MH - *Asthma/blood/epidemiology/genetics MH - Female MH - Cross-Sectional Studies MH - Mendelian Randomization Analysis MH - Male MH - Nutrition Surveys MH - Child MH - Logistic Models MH - Risk Factors PMC - PMC13313767 OTO - NOTNLM OT - Mendelian randomization OT - National Health and Nutrition Examination Survey OT - childhood asthma OT - correlation OT - serum total bilirubin COIS- The authors have no funding or conflicts of interest to disclose. EDAT- 2026/06/27 10:10 MHDA- 2026/06/28 16:09 PMCR- 2026/06/26 CRDT- 2026/06/27 01:00 PHST- 2025/07/22 00:00 [received] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/06/28 16:09 [medline] PHST- 2026/06/27 10:10 [pubmed] PHST- 2026/06/27 01:00 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - 00005792-202606260-00096 [pii] AID - MD-D-25-09095 [pii] AID - 10.1097/MD.0000000000049528 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Jun 26;105(26):e49528. doi: 10.1097/MD.0000000000049528. PMID- 42363297 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260920 LR - 20260923 IS - 2055-0928 (Electronic) IS - 2055-0928 (Linking) VI - 12 IP - 1 DP - 2026 Jun 26 TI - Effects of an infant formula containing a whey protein concentrate on feeding tolerance and markers of intestinal immune defense in Chinese infants. LID - 10.1186/s40795-026-01395-0 [doi] LID - 194 AB - BACKGROUND: Human milk (HM) bioactive components can have immune modulatory functions, impact the gut microbiome, and may result in functional benefits when added to infant formula (IF). In this single-arm, prospective, intervention study, we tested the effectiveness of an IF with a whey protein concentrate co-enriched in alpha-lactalbumin, milk fat globule membrane (MFGM), and Sn-2 palmitate resulting in protein and lipid profiles observed in HM. The outcomes tested were feeding tolerance, Bifidobacteria abundance, and intestinal and immune health of Chinese infants. METHODS: Predominantly formula-fed (FF) and breastfed (BF) infants were enrolled between 3 and 28 days and assigned to the FF (N = 60) or BF (N = 60) group, per their feeding practice, for 6 weeks. The primary endpoint was Infant Gastrointestinal Symptom Questionnaire (IGSQ) index score assessed using a validated IGSQ-13 questionnaire after 6 weeks of intervention; non-inferiority of FF vs BF was tested. Secondary endpoints included fecal Bifidobacteria abundance assessed using shotgun metagenomics sequencing; fecal short chain fatty acids (SCFAs) analyzed by ultra-performance liquid chromatography-tandem mass spectrometry; fecal markers of immune response, inflammation, intestinal barrier integrity (secretory immunoglobulin A sIgA), cytokines, calprotectin, alpha1 antitrypsin, lipocalin-2) assessed using enzyme-linked immunosorbent assay; stool consistency assessed using gastrointestinal (GI) diary; anthropometric assessments; quality of life; physician reported adverse events; and use of medications. RESULTS: Good GI tolerance was observed in both groups at V2 (mean +/- SD IGSQ score FF: 19.9 +/- 7.4; BF: 16.8 +/- 4.2); difference of means 1.35 [95% CI: -1.312, 4.012]). After 6 weeks, Bifidobacterium genus relative abundance was not significantly different between the groups. Total SCFAs were significantly higher (p < 0.05) in the FF versus BF group, driven by increased levels of valeric and propanoic acids (p < 0.05 for both). The IGSQ domain scores, stool consistency, fecal markers of immunity, inflammation, and intestinal barrier integrity (except lipocalin-2 which was significantly higher in BF vs FF), anthropometric Z-scores, common illnesses, antibiotic use, and adverse events were not significantly different between groups at week 6. CONCLUSIONS: Our results support the effectiveness of this tested infant formula in supporting good GI tolerance, growth, specific intestinal and immune health markers, and Bifidobacteria abundance similar to that of the BF group. TRIAL REGISTRATION: NCT04880083 (2021-05-06). CI - (c) 2026. The Author(s). FAU - Wang, Ying AU - Wang Y AD - Division of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Liu, Min AU - Liu M AD - Shanghai Public Health Clinical Centre, Shanghai, China. FAU - Dogra, Shaillay Kumar AU - Dogra SK AD - Nestle Research, Societe Des Produits Nestle SA, 1000, Lausanne 26, Switzerland. FAU - Vidal, Karine AU - Vidal K AD - Nestle Research, Societe Des Produits Nestle SA, 1000, Lausanne 26, Switzerland. FAU - Godin, Jean-Philippe AU - Godin JP AD - Nestle Research, Societe Des Produits Nestle SA, 1000, Lausanne 26, Switzerland. FAU - Darwish, Noura AU - Darwish N AD - Clinical Research Unit, Societe Des Produits Nestle SA, 1000, Lausanne, Switzerland. FAU - Wei, Xiaona AU - Wei X AD - Nestle Research, Societe Des Produits Nestle SA, Singapore, 618802, Singapore. FAU - Reymond, Lucas AU - Reymond L AD - Clinical Research Unit, Societe Des Produits Nestle SA, 1000, Lausanne, Switzerland. FAU - Li, Qiaoji AU - Li Q AD - Nestle R&D (China) Ltd, Beijing, 100016, China. FAU - Dong, Jie AU - Dong J AD - Wyeth Nutrition, Shanghai, 200040, China. FAU - Vyllioti, Aikaterini Themis AU - Vyllioti AT AD - Clinical Research Unit, Societe Des Produits Nestle SA, 1000, Lausanne, Switzerland. FAU - Bettler, Jodi AU - Bettler J AD - Nestle Product Technology Center-Nutrition, Societe Des Produits Nestle SA, 1800, Vevey, Switzerland. FAU - Kennedy, Elaine AU - Kennedy E AD - Nestle Development Centre Nutrition, Wyeth Nutritionals Ireland Ltd., Askeaton, Co. Limerick, Ireland. FAU - Wang, Keqing AU - Wang K AD - BGI-Shenzhen, Shenzhen, 518083, China. FAU - Zhai, Qiangrong AU - Zhai Q AD - BGI-Shenzhen, Shenzhen, 518083, China. FAU - O'Regan, Jonathan AU - O'Regan J AD - Nestle Development Centre Nutrition, Wyeth Nutritionals Ireland Ltd., Askeaton, Co. Limerick, Ireland. FAU - Samuel, Tinu Mary AU - Samuel TM AD - Nestle Product Technology Center-Nutrition, Societe Des Produits Nestle SA, 1800, Vevey, Switzerland. FAU - Cai, Wei AU - Cai W AD - Division of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. caiw204@sjtu.edu.cn. AD - Shanghai Institute of Pediatric Research, Shanghai, China. caiw204@sjtu.edu.cn. LA - eng SI - ClinicalTrials.gov/NCT04880083 PT - Journal Article DEP - 20260626 PL - England TA - BMC Nutr JT - BMC nutrition JID - 101672434 PMC - PMC13591888 OTO - NOTNLM OT - Bifidobacteria OT - Sn-2-palmitate OT - Gastrointestinal tolerance OT - Growth OT - Infant formula OT - Intestinal and immune health OT - MFGM OT - alpha-lactalbumin COIS- Declarations. Ethics approval and consent to participate: This study was approved by the ethics committees at the two institutions in China which were the Ethics Committee of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (XHEC-C-2020-053-1, and the Ethics Committee of Shanghai Public Health Clinical Center (2020-E151-01, respectively and conducted in compliance with the Declaration of Helsinki and the International Conference on Harmonization Guidelines for Good Clinical Practice. This study was also approved by the Human Genetic Resource Administrative Committee of the Ministry of Science and Technology of China according to the applicable regulation before the study was initiated. Prior to enrollment, parent(s)/legally authorized representative provided written informed consent. This trial was registered on ClinicalTrials.gov (NCT04880083). Competing interests: TMS, SKD, KV, JPG, ND, XW, LR, QL, JD, JB, EK, and JR are employees of Societe des Produits Nestle S.A., the sponsors of this trial. ATV was an employee of Societe des Produits Nestle S.A. at the time the study was conducted. KW, QZ are employees of Beijing Genomics Institute, with whom Nestle had a service agreement. YW, ML and WC received a grant from Nestle to conduct the study. The investigational products were provided by Wyeth Nutritional (China) Co., Limited. Consent for publication: Not applicable as the manuscript does not contain data from any individual person. EDAT- 2026/06/27 04:10 MHDA- 2026/06/27 04:11 PMCR- 2026/06/26 CRDT- 2026/06/26 23:51 PHST- 2024/05/08 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/06/27 04:11 [medline] PHST- 2026/06/27 04:10 [pubmed] PHST- 2026/06/26 23:51 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - 10.1186/s40795-026-01395-0 [pii] AID - 1395 [pii] AID - 10.1186/s40795-026-01395-0 [doi] PST - epublish SO - BMC Nutr. 2026 Jun 26;12(1):194. doi: 10.1186/s40795-026-01395-0. PMID- 42362911 OWN - NLM STAT- Publisher LR - 20260726 IS - 1559-064X (Electronic) IS - 1559-0631 (Linking) DP - 2026 Jun 26 TI - Diet and mycoestrogen exposure in a pregnancy cohort: the Jersey Babies pilot study. LID - 10.1038/s41370-026-00940-0 [doi] AB - BACKGROUND: Zearalenone (ZEN) is a grain-contaminating mycotoxin and potent estrogen receptor agonist linked to reproductive and perinatal disruption in animal models, with emerging epidemiologic evidence in humans. Despite widespread U.S. exposure, dietary sources remain unclear. OBJECTIVE: This pilot study assessed prenatal mycoestrogen exposure and related dietary sources in a U.S. pregnant cohort. METHODS: Pregnant women (n = 33) recruited in New Brunswick, NJ provided urine samples and completed time-matched 24-h dietary recalls at three points across pregnancy (Visit 1: 18-20 weeks; Visit 2: 24-26 weeks and Visit 3: 28-32 weeks gestation). Urinary mycoestrogens were quantified using LC/MSMS and corrected for specific gravity. RESULTS: At least one ZEN metabolite was detected in every sample (Visit, median: 1: 0.058 ng/mg; 2: 0.042 ng/mg; 3: 0.055 ng/mg), and intraclass correlation coefficients among detected metabolites ranged from 0.62 to 0.95. Across visits, Hispanic participants (39%) had 52-109% higher mycoestrogen concentrations compared to non-Hispanic participants (p < 0.05). Consumption of corn and other grain products within the past 24 h was strongly correlated with urinary concentrations of ZEN and its metabolites (r: 0.30-0.92; p < 0.05), with weaker positive correlations observed for oils and popcorn. SIGNIFICANCE: Given robust toxicologic evidence and emerging epidemiologic findings suggesting adverse maternal and child health impacts, identifying key exposure pathways is critical. IMPACT: This pilot study identifies corn and cereal-based foods as key contributors to ZEN prenatal exposure and highlights higher concentrations among Hispanic participants. By clarifying exposure pathways, these findings support improved food-safety monitoring and targeted strategies to reduce endocrine-disrupting chemical exposures during pregnancy. CI - (c) 2026. The Author(s). FAU - Rivera-Nunez, Zorimar AU - Rivera-Nunez Z AUID- ORCID: 0000-0002-0718-1807 AD - Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA. zorimar.nunez@rutgers.edu. AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. zorimar.nunez@rutgers.edu. FAU - Kinkade, Carolyn W AU - Kinkade CW AUID- ORCID: 0000-0002-8549-5553 AD - Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA. FAU - Juenke, Alyssa AU - Juenke A AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. FAU - Hansel, Megan AU - Hansel M AD - Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA. FAU - Heltberg, Daniel AU - Heltberg D AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. AD - School of Biological Sciences, University of Aberdeen, Aberdeen, Scotland, UK. FAU - Sharada, Aditi AU - Sharada A AD - Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA. FAU - Anthony, Shabree AU - Anthony S AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. FAU - Brinker, Anita AU - Brinker A AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. FAU - Fields, Jessica AU - Fields J AD - Department of Obstetrics and Gynecology, Rutgers Robert Wood Johnson University Hospital, New Brunswick, NJ, USA. FAU - Rosen, Todd AU - Rosen T AD - Department of Obstetrics and Gynecology, Rutgers Robert Wood Johnson University Hospital, New Brunswick, NJ, USA. FAU - Palomares, Kristy AU - Palomares K AD - Department of Obstetrics and Gynecology, St. Peter's University Hospital, New Brunswick, NJ, USA. FAU - Buckley, Brian AU - Buckley B AUID- ORCID: 0000-0001-7336-4321 AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. FAU - Aleksunes, Lauren M AU - Aleksunes LM AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. AD - Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA. FAU - Barrett, Emily S AU - Barrett ES AD - Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA. AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. LA - eng GR - P30 ES005022/ES/NIEHS NIH HHS/United States GR - R01 ES037903/ES/NIEHS NIH HHS/United States GR - T32 ES007148/ES/NIEHS NIH HHS/United States PT - Journal Article DEP - 20260626 PL - United States TA - J Expo Sci Environ Epidemiol JT - Journal of exposure science & environmental epidemiology JID - 101262796 SB - IM OTO - NOTNLM OT - Biomonitoring OT - Dietary exposure OT - Mycoestrogen OT - Mycotoxin OT - Pregnancy OT - Zearalenone COIS- Competing interests: ZRN, CWK, LMA and ESB mycoestrogen work has been funded by the NIH. Other authors declare no potential competing interests. Ethical approval: All study protocols were approved by the Rutgers and SPUH Institutional Review Boards and participants signed written informed consent before engaging in any study activities. EDAT- 2026/06/27 00:49 MHDA- 2026/06/27 00:49 CRDT- 2026/06/26 23:25 PHST- 2026/03/02 00:00 [received] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/06/08 00:00 [revised] PHST- 2026/06/27 00:49 [medline] PHST- 2026/06/27 00:49 [pubmed] PHST- 2026/06/26 23:25 [entrez] AID - 10.1038/s41370-026-00940-0 [pii] AID - 10.1038/s41370-026-00940-0 [doi] PST - aheadofprint SO - J Expo Sci Environ Epidemiol. 2026 Jun 26. doi: 10.1038/s41370-026-00940-0. PMID- 42362717 OWN - NLM STAT- Publisher LR - 20260626 IS - 1476-5497 (Electronic) IS - 0307-0565 (Linking) DP - 2026 Jun 26 TI - Prevalence and biopsychosocial factors associated with overweight and obesity in adults with type 1 diabetes. LID - 10.1038/s41366-026-02147-7 [doi] AB - BACKGROUND: To describe the prevalence of overweight and obesity in adults living with type 1 diabetes and examine the association between biopsychosocial factors according to weight status. METHODS: A single-center, cross-sectional study was conducted in adults with type 1 diabetes attending a tertiary hospital between 2018 and 2020. Participants completed an online survey with validated questionnaires to assess physical activity; measure anxiety and depression; evaluate the perception of health-related quality of life [Spanish version of Diabetes Quality of Life Questionnaire (EsDQoL)], assess eating disorders [Spanish version of Diabetes Eating Problem Survey (EPAD-R)] and measure neuroticism. Sociodemographic data and information from the last outpatient visit regarding diabetes history, long-term complications, current insulin therapy, anthropometric measurements and laboratory data were also included. RESULTS: Data from 459 surveys were available for analysis. Participants had a mean (SD) of age of 44.7 (14.0) years; 55.6% were women; BMI 26.0 (4.7) kg/m(2) and the HbA(1c) was 7.57%. The prevalence of overweight (BMI 25-29.9 kg/m(2)) and obesity (BMI > 30 kg/m(2)) was 38.8% and 14.8%, respectively, with 10.6% being class I (30-34.9 kg/m(2)), 2.2% class II (35-39.9 kg/m(2)) and 2.0% class III (>40 kg/m(2)). Older age, living with a child/children, a higher EPAD-R score, a higher total insulin doses, receiving lipid-lowering therapy, and a higher EsDQoL score in the diabetes-related worries dimension were associated with a greater likelihood of living with obesity. CONCLUSIONS: Overweight and obesity are highly prevalent among adults living with type 1 diabetes, and the identified biopsychosocial factors reveals how excess weight arises from complex interactions among demographic, clinical, and psychological influences. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Tundidor, Diana AU - Tundidor D AUID- ORCID: 0000-0002-8629-9706 AD - Endocrinology and Nutrition Department, Obesity Section, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Endocrinology and Nutrition Department, Diabetes Unit, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Barcelona, Spain. FAU - Blanco, Jesus AU - Blanco J AD - Endocrinology and Nutrition Department, Diabetes Unit, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Barcelona, Spain. FAU - Canizares, Silvia AU - Canizares S AD - Clinical Psychology and Psychobiology Department, Section of Clinical Health Psychology, Clinical Institute of Neurosciences, Hospital Clinic de Barcelona, Barcelona, Spain. FAU - Segui, Nuria AU - Segui N AD - Endocrinology and Nutrition Department, Obesity Section, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Endocrinology and Nutrition Department, Diabetes Unit, Hospital Clinic de Barcelona, Barcelona, Spain. FAU - Obach, Amadeu AU - Obach A AD - Clinical Psychology and Psychobiology Department, Section of Clinical Health Psychology, Clinical Institute of Neurosciences, Hospital Clinic de Barcelona, Barcelona, Spain. FAU - Molero, Judith AU - Molero J AD - Endocrinology and Nutrition Department, Obesity Section, Hospital Clinic de Barcelona, Barcelona, Spain. FAU - Conget, Ignacio AU - Conget I AD - Endocrinology and Nutrition Department, Diabetes Unit, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Barcelona, Spain. AD - Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Barcelona, Spain. FAU - Gimenez, Marga AU - Gimenez M AD - Endocrinology and Nutrition Department, Diabetes Unit, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Barcelona, Spain. AD - Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Barcelona, Spain. FAU - Vidal, Josep AU - Vidal J AUID- ORCID: 0000-0002-4564-4518 AD - Endocrinology and Nutrition Department, Obesity Section, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Barcelona, Spain. AD - Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Barcelona, Spain. FAU - Flores, Lilliam AU - Flores L AUID- ORCID: 0000-0001-5765-8813 AD - Endocrinology and Nutrition Department, Obesity Section, Hospital Clinic de Barcelona, Barcelona, Spain. lflores@clinic.cat. AD - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Barcelona, Spain. lflores@clinic.cat. AD - Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Barcelona, Spain. lflores@clinic.cat. LA - eng PT - Journal Article DEP - 20260626 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 SB - IM COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/06/27 00:53 MHDA- 2026/06/27 00:53 CRDT- 2026/06/26 23:20 PHST- 2025/04/14 00:00 [received] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/06/01 00:00 [revised] PHST- 2026/06/27 00:53 [medline] PHST- 2026/06/27 00:53 [pubmed] PHST- 2026/06/26 23:20 [entrez] AID - 10.1038/s41366-026-02147-7 [pii] AID - 10.1038/s41366-026-02147-7 [doi] PST - aheadofprint SO - Int J Obes (Lond). 2026 Jun 26. doi: 10.1038/s41366-026-02147-7. PMID- 42362648 OWN - NLM STAT- Publisher LR - 20260626 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) DP - 2026 Jun 26 TI - Gastric ultrasound reveals no association between prolonged fasting duration and gastric residual volume in pediatric patients. LID - 10.1038/s41598-026-57602-2 [doi] AB - Prolonged preoperative fasting is common in pediatric anesthesia, yet its effect on gastric residual volume (GRV) remains inadequately explored. We conducted a prospective cross-sectional study to examine the association between prolonged fasting duration and GRV measured using point-of-care gastric ultrasonography. A total of 491 children aged 1-12 years scheduled for elective surgery under general anesthesia after fasting more than 8 h were included. GRV was measured using point-of-care gastric ultrasonography and calculated using a validated formula, then normalized to body weight. The primary endpoint was the association between fasting duration and weight-adjusted GRV (GRV/WT). Among the participants (median age 89 months; 308 boys), fifteen patients (3.05%) had a stomach at risk of aspiration (GRV/WT > 1.25 mL kg(-1)) and 29 (5.91%) showed high-risk gastric antrum morphology. Spearman correlation analysis demonstrated no significant association between prolonged fasting duration and GRV/WT (rho = 0.037, 95% CI: - 0.054 to 0.128, p = 0.41). GRV/WT correlated positively with age and negatively with body mass index. These findings suggest that prolonged preoperative fasting does not independently associate with GRV in pediatric patients. CI - (c) 2026. The Author(s). FAU - Wu, Qingda AU - Wu Q AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. FAU - Liu, Bin AU - Liu B AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. AD - Department of Anesthesiology, Heyou Hospital, Foshan, China. FAU - Wang, Zhouwu AU - Wang Z AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. FAU - Chen, Lingzhi AU - Chen L AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. FAU - Liu, Hao AU - Liu H AD - Department of Anesthesiology, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. AD - Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Zou, Qi AU - Zou Q AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. FAU - Zhao, Yongzhen AU - Zhao Y AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. FAU - Ding, Zhenhao AU - Ding Z AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. FAU - Chen, Lu AU - Chen L AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. chenlu200505399@163.com. FAU - Zheng, Zhenwei AU - Zheng Z AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. wind_8228@163.com. LA - eng GR - No.72 [2024] - 159/Shantou Medical Health Science and Technology Project (CN)/ PT - Journal Article DEP - 20260626 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM OTO - NOTNLM OT - Fasting OT - Gastric residual volume OT - Gastric ultrasonography OT - Pediatric COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: Institutional Review Board approval was obtained. EDAT- 2026/06/27 04:10 MHDA- 2026/06/27 04:10 CRDT- 2026/06/26 23:18 PHST- 2026/03/10 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/06/27 04:10 [medline] PHST- 2026/06/27 04:10 [pubmed] PHST- 2026/06/26 23:18 [entrez] AID - 10.1038/s41598-026-57602-2 [pii] AID - 10.1038/s41598-026-57602-2 [doi] PST - aheadofprint SO - Sci Rep. 2026 Jun 26. doi: 10.1038/s41598-026-57602-2. PMID- 42362166 OWN - NLM STAT- MEDLINE DCOM- 20260822 LR - 20260822 IS - 1873-6513 (Electronic) IS - 0885-3924 (Linking) VI - 72 IP - 4 DP - 2026 Oct TI - Perceived Stigma, Psychological Distress, and Symptom Burden in Decompensated Cirrhosis. PG - 457-466.e2 LID - S0885-3924(26)00860-2 [pii] LID - 10.1016/j.jpainsymman.2026.06.021 [doi] AB - CONTEXT: Despite perceived stigma's impact in HIV, mental illness, and obesity, its association with adverse outcomes in decompensated cirrhosis (DC) remains under-investigated. OBJECTIVES: We aimed to quantify liver-related perceived stigma and examine its associations with patient-reported psychological distress and symptom burden among patients with DC. METHODS: We conducted a cross-sectional study of outpatients with DC from August 2018 to September 2022. Participants completed validated instruments: the four-item perceived stigma domain from the Short-Form Liver Disease Quality of Life questionnaire (range 0-100; reverse-scored where higher scores = greater stigma), the Hospital Anxiety and Depression Scale (0-21; scores >/=8: clinically significant anxiety and depression symptoms), and the Revised Edmonton Symptom Assessment System (0-100; scores >/=40: moderate-to-severe burden). We used multivariable linear regression adjusted for age, gender, etiology, and DC severity. RESULTS: Among 218/312 (70%) eligible patients (median age 60 [interquartile range 51-65]; 54% male; 58% alcohol-related; median MELD-Na 16), mean stigma score was 34.3 (standard deviation 26.3). Greater stigma was reported by those with advanced disease (Child-Pugh A vs. B vs. C: 19.4 vs. 32.2 vs. 42.2; P = 0.001) and younger patients (18-44 vs. 45-64 vs. >/=65: 38.6 vs. 37.1 vs. 26.2; P = 0.019). In adjusted analyses, greater stigma was independently associated with higher depression symptoms (beta = 0.08, P < 0.001), anxiety symptoms (beta = 0.07, P < 0.001), and symptom burden (beta = 0.33, P < 0.001). CONCLUSIONS: Among patients with DC, younger adults and those with advanced disease reported greater perceived stigma, independently associated with higher psychological distress and symptom burden. These findings highlight perceived stigma as a modifiable target for palliative care-focused interventions to improve patient-reported outcomes in DC. CI - Copyright (c) 2026 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved. FAU - Bromfield, Brittany AU - Bromfield B AD - Department of Gastroenterology and Hepatology (B.B.), Brigham and Women's Hospital, Boston, Massachusetts, USA. FAU - Zeng, Chengbo AU - Zeng C AD - Patient Reported Outcomes, Values, and Experience (PROVE) Center (C.Z.), Brigham and Women's Hospital, Boston, Massachusetts, USA. FAU - Ojeaburu, Leslie AU - Ojeaburu L AD - Department of Medicine (L.O.), Brigham and Women's Hospital, Boston, Massachusetts, USA. FAU - Mason, Nancy AU - Mason N AD - Division of Palliative Care and Geriatric Medicine (N.M., K.G.E., M.R., S.K., K.O., M.S.D.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Engel, Kirsten G AU - Engel KG AD - Division of Palliative Care and Geriatric Medicine (N.M., K.G.E., M.R., S.K., K.O., M.S.D.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Rowland, Michaela AU - Rowland M AD - Division of Palliative Care and Geriatric Medicine (N.M., K.G.E., M.R., S.K., K.O., M.S.D.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Kenimer, Sara AU - Kenimer S AD - Division of Palliative Care and Geriatric Medicine (N.M., K.G.E., M.R., S.K., K.O., M.S.D.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - O'Brien, Karen AU - O'Brien K AD - Division of Palliative Care and Geriatric Medicine (N.M., K.G.E., M.R., S.K., K.O., M.S.D.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Diop, Michelle S AU - Diop MS AD - Division of Palliative Care and Geriatric Medicine (N.M., K.G.E., M.R., S.K., K.O., M.S.D.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Donlan, John AU - Donlan J AD - Department of Internal Medicine (J.D.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Indriolo, Teresa AU - Indriolo T AD - Division of Pain Medicine (T.I.), Stanford University School of Medicine, Palo Alto, California, USA. FAU - Li, Lucinda AU - Li L AD - Department of Medicine, David Geffen School of Medicine at UCLA (L.L.), Los Angeles, California, USA. FAU - Zhu, Enya AU - Zhu E AD - Department of Medicine, Duke University School of Medicine (E.Z.), Durham, North Carolina, USA. FAU - Armstrong, Malia E AU - Armstrong ME AD - Gastrointestinal Division (M.E.A., G.B., W.M., A.D., X.L., W.Z., N.N.U.), Liver Center, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Bizup, Grace AU - Bizup G AD - Gastrointestinal Division (M.E.A., G.B., W.M., A.D., X.L., W.Z., N.N.U.), Liver Center, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Munroe, Will AU - Munroe W AD - Gastrointestinal Division (M.E.A., G.B., W.M., A.D., X.L., W.Z., N.N.U.), Liver Center, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Dalvi, Anushka AU - Dalvi A AD - Gastrointestinal Division (M.E.A., G.B., W.M., A.D., X.L., W.Z., N.N.U.), Liver Center, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Li, Xing AU - Li X AD - Gastrointestinal Division (M.E.A., G.B., W.M., A.D., X.L., W.Z., N.N.U.), Liver Center, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Lau-Min, Kelsey S AU - Lau-Min KS AD - Division of Hematology and Oncology (K.S.L., A.E.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Brown, Cristal AU - Brown C AD - Department of Internal Medicine (C.B.), University of Texas at Austin Dell Medical School, Austin, Texas, USA. FAU - Zhang, Wei AU - Zhang W AD - Gastrointestinal Division (M.E.A., G.B., W.M., A.D., X.L., W.Z., N.N.U.), Liver Center, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - El-Jawahri, Areej AU - El-Jawahri A AD - Division of Hematology and Oncology (K.S.L., A.E.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Ufere, Nneka N AU - Ufere NN AD - Gastrointestinal Division (M.E.A., G.B., W.M., A.D., X.L., W.Z., N.N.U.), Liver Center, Massachusetts General Hospital, Boston, Massachusetts, USA. Electronic address: nneka.ufere@mgh.harvard.edu. LA - eng PT - Journal Article DEP - 20260626 PL - United States TA - J Pain Symptom Manage JT - Journal of pain and symptom management JID - 8605836 SB - IM MH - Humans MH - Male MH - Female MH - Symptom Burden MH - *Liver Cirrhosis/psychology MH - Cross-Sectional Studies MH - Middle Aged MH - Aged MH - *Psychological Distress MH - *Social Stigma MH - Quality of Life MH - Depression MH - Anxiety MH - Severity of Illness Index OTO - NOTNLM OT - Decompensated cirrhosis OT - anxiety OT - depression OT - patient-reported outcomes OT - stigma OT - symptom burden EDAT- 2026/06/27 00:52 MHDA- 2026/08/22 23:43 CRDT- 2026/06/26 19:35 PHST- 2026/04/27 00:00 [received] PHST- 2026/06/17 00:00 [revised] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/08/22 23:43 [medline] PHST- 2026/06/27 00:52 [pubmed] PHST- 2026/06/26 19:35 [entrez] AID - S0885-3924(26)00860-2 [pii] AID - 10.1016/j.jpainsymman.2026.06.021 [doi] PST - ppublish SO - J Pain Symptom Manage. 2026 Oct;72(4):457-466.e2. doi: 10.1016/j.jpainsymman.2026.06.021. Epub 2026 Jun 26. PMID- 42359254 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 1664-042X (Print) IS - 1664-042X (Electronic) IS - 1664-042X (Linking) VI - 17 DP - 2026 TI - Obesity is associated with suppressed bone turnover: a systematic review and meta-analysis. PG - 1793838 LID - 10.3389/fphys.2026.1793838 [doi] LID - 1793838 AB - BACKGROUND: Obesity is an increasingly serious public health issue on a global scale. Although there is increasing research on the relationship between obesity and biochemical markers of bone turnover, this relationship is complex and unclear. We conducted a systematic review and meta-analysis aimed at comparing the concentrations of biochemical markers of bone turnover between individuals with obesity and those with normal-weight. METHOD: A systematic search was conducted using the PubMed, EMBASE, Web of Science, Cochrane Library, and EBSCO databases from database inception to December 15, 2025. Two researchers screened the literature according to the inclusion and exclusion criteria and extracted valid data for quality evaluation. RESULTS: The results ultimately included 14 articles with a total of 4612 subjects. Compared with normal-weight individuals, individuals with obesity showed no significant difference in alkaline phosphatase (ALP) levels. Procollagen type I N-terminal propeptide (PINP) levels were significantly reduced in individuals with obesity. Osteocalcin (OCN) levels were also decreased overall, but subgroup analysis showed that this reduction was significant in children and adolescents, whereas no significant difference was observed in adults. No significant difference was observed in C-terminal telopeptide of type I collagen (CTX-I) or N-terminal telopeptide of type I collagen (NTX) levels. CONCLUSION: This meta-analysis suggests that obesity is associated with suppressed bone turnover, mainly reflected by reduced levels of bone formation markers. PINP levels were significantly decreased in individuals with obesity, whereas the reduction in OCN appeared to be age-dependent, with significant suppression observed in children and adolescents but not in adults. However, the robustness of the bone resorption results is insufficient and requires further validation through additional studies. Further studies are needed to clarify the mechanisms by which obesity affects skeletal health and to identify potential targets for clinical intervention. CI - Copyright (c) 2026 Lin, Liu, Chen and Liu. FAU - Lin, Haiqi AU - Lin H AD - School of Physical Education and Sports Science, South China Normal University, Guangzhou, Guangdong, China. AD - College of Physical Education, South China University of Technology, Guangzhou, Guangdong, China. FAU - Liu, Xiaohua AU - Liu X AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Chen, Binglin AU - Chen B AD - The Second School of Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China. FAU - Liu, Chengyi AU - Liu C AD - School of Physical Education and Sports Science, South China Normal University, Guangzhou, Guangdong, China. LA - eng PT - Journal Article PT - Review DEP - 20260610 PL - Switzerland TA - Front Physiol JT - Frontiers in physiology JID - 101549006 PMC - PMC13290598 OTO - NOTNLM OT - bone OT - bone formation OT - bone resorption OT - bone turnover (markers) OT - obesity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/26 06:38 MHDA- 2026/06/26 06:39 PMCR- 2026/06/10 CRDT- 2026/06/26 04:45 PHST- 2026/01/22 00:00 [received] PHST- 2026/05/28 00:00 [revised] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/06/26 06:39 [medline] PHST- 2026/06/26 06:38 [pubmed] PHST- 2026/06/26 04:45 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.3389/fphys.2026.1793838 [doi] PST - epublish SO - Front Physiol. 2026 Jun 10;17:1793838. doi: 10.3389/fphys.2026.1793838. eCollection 2026. PMID- 42356915 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 12 DP - 2026 Jun 21 TI - Explainable Machine Learning Using Sensor-Derived Biomechanical Features to Classify Elevated VALR-Related Loading Across Midsole Hardness Conditions in School-Aged Boys. LID - 10.3390/s26123942 [doi] LID - 3942 AB - (1) Background: Changes in midsole hardness may affect lower-limb impact loading during forefoot strike (FFS) running in children, yet the biomechanical basis for discriminating elevated VALR-related loading remains unclear. (2) Methods: Fourteen school-aged boys performed FFS running tests in experimental shoes with four midsole hardness levels (37, 42, 47, and 52 Shore C). Lower-limb kinematics and surface electromyography (sEMG) data were collected during the dominant leg stance phase. After preprocessing, VALR was calculated from 336 valid trials, and 28 stance-phase biomechanical features were extracted, yielding a final machine-learning dataset of 324 trials after excluding incomplete feature data. VALR was used to compare loading changes and define trial-level elevated-loading labels based on the median VALR value. Classification models were evaluated under participant-level GroupKFold validation, and XGBoost was retained for exploratory SHAP analysis. (3) Results: VALR showed an upward trend with increasing hardness, but no statistically supported change point was identified. XGBoost achieved an accuracy of 75.93%, precision of 74.14%, recall of 79.63%, F1-value of 0.768, and pooled out-of-fold AUC of 0.738. SHAP analysis indicated that distal and non-sagittal kinematic features contributed most to model classification. (4) Conclusions: Elevated VALR-related loading during children's FFS running may be characterized by a multi-feature model-based pattern rather than a fixed midsole hardness threshold. FAU - Chen, Yiyao AU - Chen Y AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Gao, Zixiang AU - Gao Z AUID- ORCID: 0000-0002-4345-8201 AD - Faculty of Kinesiology, University of Calgary, Calgary, AB T2N 1N4, Canada. FAU - Li, Fengping AU - Li F AUID- ORCID: 0009-0001-2206-2750 AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Wang, Dongxu AU - Wang D AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Pan, Jianqi AU - Pan J AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Wang, Yucheng AU - Wang Y AUID- ORCID: 0009-0003-1962-4147 AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Chen, Diwei AU - Chen D AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Zhou, Zhanyi AU - Zhou Z AD - Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, 18011 Granada, Spain. FAU - Gao, Lidong AU - Gao L AD - Department of Material Science and Technology, Audi Hungaria Faculty of Automotive Engineering, Szechenyi Istvan University, 9026 Gyor, Hungary. FAU - Chen, Kuiyu AU - Chen K AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Ye, Zhaolong AU - Ye Z AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Gu, Yaodong AU - Gu Y AUID- ORCID: 0000-0003-2187-9440 AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. AD - Department of Kinesiology, Hungarian University of Sports Science, 1123 Budapest, Hungary. LA - eng PT - Journal Article DEP - 20260621 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - Male MH - Biomechanical Phenomena/physiology MH - Electromyography MH - Hardness/physiology MH - *Machine Learning MH - *Running/physiology MH - Child MH - Shoes MH - Boosting Machine Learning Algorithms PMC - PMC13307089 OTO - NOTNLM OT - SHAP OT - XGBoost OT - elevated VALR-related loading OT - forefoot strike OT - midsole hardness OT - school-aged boys COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/06/26 13:10 MHDA- 2026/06/27 07:40 PMCR- 2026/06/21 CRDT- 2026/06/26 01:19 PHST- 2026/05/06 00:00 [received] PHST- 2026/06/15 00:00 [revised] PHST- 2026/06/18 00:00 [accepted] PHST- 2026/06/27 07:40 [medline] PHST- 2026/06/26 13:10 [pubmed] PHST- 2026/06/26 01:19 [entrez] PHST- 2026/06/21 00:00 [pmc-release] AID - s26123942 [pii] AID - sensors-26-03942 [pii] AID - 10.3390/s26123942 [doi] PST - epublish SO - Sensors (Basel). 2026 Jun 21;26(12):3942. doi: 10.3390/s26123942. PMID- 42356815 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 12 DP - 2026 Jun 17 TI - Prediction of Nocturnal Hypoglycemia Following Exercise in Type 1 Diabetes Using Temporally Structured CGM-Derived Digital Biomarkers. LID - 10.3390/s26123842 [doi] LID - 3842 AB - Nocturnal hypoglycemia (NH) following exercise represents a critical challenge in the management of type 1 diabetes (T1D), particularly in pediatric populations, where its occurrence is associated with severe adverse outcomes and increased caregiver burden. This study aimed to identify an interpretable early signature based on CGM-derived digital biomarkers of post-exercise NH risk in children and adolescents with T1D. CGM data from 49 pediatric subjects (DirecNet cohort) were used to extract several CGM metrics across two temporal configurations: (i) Exercise + Cumulative, where features were computed over the exercise window and over an extended window spanning from exercise onset through recovery (16:00-17:00 and 16:00-22:00); and (ii) Exercise + Post-exercise, where features were computed separately over two non-overlapping intervals, capturing the exercise phase and the subsequent recovery phase (16:00-17:00 and 17:00-22:00). A Random Forest classifier was trained within a Leave-One-Out Cross Validation framework, incorporating variance inflation factor (VIF)-based multicollinearity filtering, minimum redundancy-maximum relevance (mRMR) feature selection, and SMOTE-based class balancing. The Exercise + Post-exercise configuration achieved superior performance: balanced accuracy (BA) = 76.9%, F1-score = 0.71, Area Under Receiver Operating Characteristic Curve (ROC-AUC) = 0.75, outperforming the Exercise + Cumulative configuration; this result was achieved using only five features: CONGA-15_EX (short-term glucose variability during exercise) emerged as the most robust predictor, alongside below_54 and above_250 (time spent in hypoglycemic and hyperglycemic ranges), MAG (mean absolute glucose change), and GRADE_hypo (hypoglycemia risk score). The generalizability of the temporal framework was further supported by independent validation on the OhioT1DM free-living cohort, where the Exercise + Post-exercise configuration (BA = 76.3%, ROC-AUC = 0.804) again outperformed the cumulative approach. These results suggest that a small set of interpretable CGM-derived features, extracted from the exercise and recovery windows, can effectively discriminate pediatric T1D subjects at risk of NH, supporting the development of lightweight CGM-only decision support tools for safer exercise management. FAU - Piersanti, Agnese AU - Piersanti A AD - Department of Information Engineering, Universita Politecnica delle Marche, Via Brecce Bianche 12, 60131 Ancona, Italy. FAU - Manes, Gaia Maria AU - Manes GM AD - Department of Information Engineering, Universita Politecnica delle Marche, Via Brecce Bianche 12, 60131 Ancona, Italy. FAU - Del Giudice, Libera Lucia AU - Del Giudice LL AUID- ORCID: 0009-0008-0723-1289 AD - Department of Information Engineering, Universita Politecnica delle Marche, Via Brecce Bianche 12, 60131 Ancona, Italy. FAU - Burattini, Laura AU - Burattini L AD - Department of Information Engineering, Universita Politecnica delle Marche, Via Brecce Bianche 12, 60131 Ancona, Italy. FAU - Gobl, Christian AU - Gobl C AD - Department of Obstetrics and Gynaecology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. FAU - Tura, Andrea AU - Tura A AUID- ORCID: 0000-0003-3466-5900 AD - CNR Institute of Neuroscience, Corso Stati Uniti 4, 35127 Padova, Italy. FAU - Morettini, Micaela AU - Morettini M AUID- ORCID: 0000-0002-8327-8379 AD - Department of Information Engineering, Universita Politecnica delle Marche, Via Brecce Bianche 12, 60131 Ancona, Italy. LA - eng PT - Journal Article DEP - 20260617 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 RN - 0 (Biomarkers) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/blood MH - *Hypoglycemia/diagnosis/blood MH - Continuous Glucose Monitoring MH - *Biomarkers/blood MH - *Exercise/physiology MH - Adolescent MH - Child MH - Female MH - Male MH - Blood Glucose/analysis PMC - PMC13307307 OTO - NOTNLM OT - SMOTE OT - continuous glucose monitoring OT - exercise OT - feature engineering OT - machine learning OT - nocturnal hypoglycemia OT - type 1 diabetes COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 13:10 MHDA- 2026/06/27 07:40 PMCR- 2026/06/17 CRDT- 2026/06/26 01:19 PHST- 2026/05/07 00:00 [received] PHST- 2026/06/09 00:00 [revised] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/06/27 07:40 [medline] PHST- 2026/06/26 13:10 [pubmed] PHST- 2026/06/26 01:19 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - s26123842 [pii] AID - sensors-26-03842 [pii] AID - 10.3390/s26123842 [doi] PST - epublish SO - Sensors (Basel). 2026 Jun 17;26(12):3842. doi: 10.3390/s26123842. PMID- 42356382 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 19 TI - Assessing the Nutritional and Neurodevelopmental Status in Children Attending Preschools in a Neighborhood in Bogota, Colombia. LID - 10.3390/nu18121996 [doi] LID - 1996 AB - Background: Early childhood nutrition is strongly associated with neurodevelopmental outcomes, particularly in socially vulnerable settings. Limited evidence is available describing the relationship between nutritional status, food security, and neurodevelopment among preschool children in low-income urban areas of Colombia. This study aimed to evaluate nutritional status, household food insecurity, and neurodevelopmental outcomes in children attending early childhood centers in El Codito, Bogota, and to explore the association between anthropometric indicators and neurodevelopmental performance. Methods: A cross-sectional study was conducted in children enrolled in community childcare centers. Nutritional status was assessed using anthropometric indicators according to World Health Organization growth standards, including weight for age, height for age, and body mass index for age. Neurodevelopment was evaluated using the Escala Abreviada de Desarrollo (EAD). Household food insecurity was measured through a validated questionnaire. Descriptive statistics were performed, and associations between variables were analyzed using correlation tests and group comparisons according to data distribution. Results: Most participants presented adequate nutritional status; however, a proportion of children showed risk of stunting or excess weight. Neurodevelopmental scores were generally within expected ranges, although variability was observed across developmental domains. Significant associations were identified between certain anthropometric indicators and neurodevelopmental outcomes. Moderate to severe household food insecurity was identified in 21.4% of participating households. Conclusions: Nutritional status and household food insecurity represent important contextual factors for child health in vulnerable urban populations. These findings highlight the importance of integrated nutritional and developmental monitoring strategies within early childhood programs. Further longitudinal studies are required to clarify causal pathways and to guide targeted public health interventions in similar contexts. FAU - Aguilera-Arino, Laura Sofia AU - Aguilera-Arino LS AD - Neuroscience Research Group (Neuros), Centro de Neurociencia-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Talero-Gutierrez, Claudia AU - Talero-Gutierrez C AUID- ORCID: 0000-0003-1601-5015 AD - Neuroscience Research Group (Neuros), Centro de Neurociencia-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Velez-Van-Merbeeke, Alberto AU - Velez-Van-Merbeeke A AUID- ORCID: 0000-0002-8889-4170 AD - Neuroscience Research Group (Neuros), Centro de Neurociencia-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Pedraza-Lopez, Natalia AU - Pedraza-Lopez N AUID- ORCID: 0009-0001-3491-5212 AD - Clinical Research Group-Epidemiological Studies Line, School of Medicine and Health Sciences, Universidad del Rosario, Quinta de Mutis Campus, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Patino-Rattiva, Maria AU - Patino-Rattiva M AD - Undergraduate Neuroscience Research Group (Semineuros), Center of Neuroscience-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Pastrana-Bustamante, Isabella AU - Pastrana-Bustamante I AD - Undergraduate Neuroscience Research Group (Semineuros), Center of Neuroscience-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Ospina-Arias, Juan Andres AU - Ospina-Arias JA AD - Undergraduate Neuroscience Research Group (Semineuros), Center of Neuroscience-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Quijano-Zauner, Mariana AU - Quijano-Zauner M AD - Undergraduate Neuroscience Research Group (Semineuros), Center of Neuroscience-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Velasquez, Maria Jose AU - Velasquez MJ AD - Undergraduate Neuroscience Research Group (Semineuros), Center of Neuroscience-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Carvajal-Rincon, Sara Sofia AU - Carvajal-Rincon SS AUID- ORCID: 0009-0001-7394-5588 AD - Undergraduate Neuroscience Research Group (Semineuros), Center of Neuroscience-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Pinzon-Rondon, Angela Maria AU - Pinzon-Rondon AM AD - Clinical Research Group-Epidemiological Studies Line, School of Medicine and Health Sciences, Universidad del Rosario, Quinta de Mutis Campus, Carrera 24 #63c-69, Bogota 111221, Colombia. LA - eng PT - Journal Article DEP - 20260619 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Colombia/epidemiology MH - *Nutritional Status MH - Child, Preschool MH - Cross-Sectional Studies MH - Female MH - Male MH - Neurodevelopment MH - *Child Development MH - Food Insecurity MH - Anthropometry MH - Urban Population MH - Poverty PMC - PMC13305189 OTO - NOTNLM OT - anthropometry OT - child development OT - malnutrition OT - neurodevelopmental disorders OT - nutritional status COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 06:40 MHDA- 2026/06/27 07:10 PMCR- 2026/06/19 CRDT- 2026/06/26 01:17 PHST- 2026/05/12 00:00 [received] PHST- 2026/06/08 00:00 [revised] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 06:40 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - nu18121996 [pii] AID - nutrients-18-01996 [pii] AID - 10.3390/nu18121996 [doi] PST - epublish SO - Nutrients. 2026 Jun 19;18(12):1996. doi: 10.3390/nu18121996. PMID- 42356370 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 19 TI - Eating Disorder Risk Among Italian University Students: A Cross-Sectional Screening Study Using BMI, EAT-26, and EDE-Q 6.0. LID - 10.3390/nu18121984 [doi] LID - 1984 AB - Background/Objectives: Eating disorders (EDs) are among the most severe psychiatric conditions affecting young people, with increasing prevalence in the post-pandemic period. This study assessed the prevalence of ED risk and dysfunctional eating behaviors among Italian university students, a population poorly characterized with respect to ED risk, and examined associations with key socio-demographic and anthropometric variables. Methods: A cross-sectional online screening study was conducted between August 2023 and February 2026 with 401 Italian university students (306 women and 95 men). Participants completed the validated Italian versions of the Eating Attitudes Test-26 (EAT-26) and the Eating Disorder Examination Questionnaire 6.0 (EDE-Q 6.0), alongside self-reported anthropometric data. Multiple linear regression analyses were performed to identify predictors of ED risk scores. Results: A total of 37.9% of participants had BMI outside the normal range (19.7% underweight; 18.2% overweight or obese). EAT-26 scores exceeded the clinical cut-off in 28.4% of participants (women: 35.6%; men: 5.3%). EDE-Q 6.0 global scores exceeded the clinical cut-off in 21.0% (women: 25.8%; men: 5.3%). Only 45.4% showed no anthropometric or questionnaire-based screening risk indicators (i.e., scores above the clinical cut-off on the EAT-26 or EDE-Q 6.0). BMI was negatively associated with EAT-26 scores in the total sample and in women, while a positive association between BMI and EDE-Q 6.0 scores was observed in men. Conclusions: A substantial proportion of Italian university students, particularly women, presented screening-based indicators of ED risk. The combined use of anthropometric and questionnaire-based screening tools provides a more comprehensive risk assessment than either measure alone, highlighting the need for multidimensional screening programs. FAU - Gosti, Valeria AU - Gosti V AUID- ORCID: 0009-0000-6071-2497 AD - Department of Human Sciences, Universita degli Studi Guglielmo Marconi, 00193 Rome, Italy. AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. FAU - Coletta, Antonella AU - Coletta A AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. FAU - Vinci, Andrea Carolina AU - Vinci AC AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. FAU - Massaro, Francesca AU - Massaro F AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. FAU - Foti, Francesca AU - Foti F AD - Department of Educational Sciences, University of Catania, 95124 Catania, Italy. FAU - Koch, Giacomo AU - Koch G AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. AD - Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy. FAU - Gelfo, Francesca AU - Gelfo F AUID- ORCID: 0000-0002-3935-2164 AD - Department of Human Sciences, Universita degli Studi Guglielmo Marconi, 00193 Rome, Italy. AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. FAU - Betti, Viviana AU - Betti V AUID- ORCID: 0000-0003-3429-2104 AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. AD - Department of Psychology, Sapienza University of Rome, 00185 Rome, Italy. FAU - Petrosini, Laura AU - Petrosini L AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. FAU - Picazio, Silvia AU - Picazio S AUID- ORCID: 0000-0002-1784-7537 AD - Department of Human Sciences, Universita degli Studi Guglielmo Marconi, 00193 Rome, Italy. AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. LA - eng GR - GR-2019-2369640/Ministry of Health/ PT - Journal Article DEP - 20260619 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Male MH - Cross-Sectional Studies MH - Italy/epidemiology MH - *Feeding and Eating Disorders/epidemiology/diagnosis MH - *Students/psychology/statistics & numerical data MH - *Body Mass Index MH - Young Adult MH - Universities MH - Adult MH - Surveys and Questionnaires MH - Risk Factors MH - Prevalence MH - Adolescent MH - Feeding Behavior/psychology PMC - PMC13304807 OTO - NOTNLM OT - EAT-26 OT - EDE-Q 6.0 OT - body mass index OT - eating disorders OT - gender differences OT - university students COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 07:10 PMCR- 2026/06/19 CRDT- 2026/06/26 01:17 PHST- 2026/05/11 00:00 [received] PHST- 2026/06/08 00:00 [revised] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - nu18121984 [pii] AID - nutrients-18-01984 [pii] AID - 10.3390/nu18121984 [doi] PST - epublish SO - Nutrients. 2026 Jun 19;18(12):1984. doi: 10.3390/nu18121984. PMID- 42356337 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 17 TI - Ultra-Processed Food Consumption Is Independently Associated with Higher HbA1c and Poor Glycemic Control in Adults with Type 2 Diabetes. LID - 10.3390/nu18121951 [doi] LID - 1951 AB - Background/Objectives: Ultra-processed food (UPF) consumption has been linked to type 2 diabetes mellitus (T2DM) incidence, but its association with glycemic control in individuals already living with T2DM remains less well characterized. We evaluated the relationship between UPF consumption, assessed with the Turkish version of the short Screening Questionnaire of Highly Processed Food Consumption (sQ-HPF), and HbA1c and poor glycemic control in adults with T2DM. Methods: In this single-centre, cross-sectional observational study, 425 adults aged 18-65 years with T2DM of at least 6 months' duration were consecutively recruited at a tertiary general internal medicine outpatient clinic. UPF consumption was assessed with the Turkish sQ-HPF (range 0-11; scores >/= 6 = high UPF consumption). HbA1c was the primary outcome (continuous and dichotomized at 7.0%). Multiple linear and binary logistic regression analyses were performed with hierarchical adjustment for age, sex, body mass index (BMI), diabetes duration, and insulin-based treatment. Results: Total UPF score was positively correlated with HbA1c (r = 0.423, p < 0.001). In the fully adjusted linear model, each one-point increase in total UPF score was associated with a 0.418% higher HbA1c (95% CI: 0.333-0.503; beta = 0.413; p < 0.001), explaining 28.9% of HbA1c variance. In the fully adjusted logistic model, each one-point increase in total UPF score was associated with 25.0% higher odds of poor glycemic control (OR = 1.250, 95% CI: 1.110-1.408, p < 0.001). Insulin-based treatment and male sex were also independent predictors. UPF score was not significantly associated with lipid parameters or C-reactive protein. Conclusions: Higher UPF consumption, captured by a brief validated screener, was independently associated with poorer glycemic control in Turkish adults with T2DM. Brief UPF screening may help identify patients who would benefit from targeted nutritional intervention. FAU - Otay Lule, Nezihe AU - Otay Lule N AUID- ORCID: 0000-0003-3664-6383 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Gaziantep University, 27310 Gaziantep, Turkiye. FAU - Sahin, Serpil AU - Sahin S AUID- ORCID: 0009-0009-7541-202X AD - Department of Internal Medicine, Faculty of Medicine, Gaziantep University, 27310 Gaziantep, Turkiye. FAU - Lule, Kemal Ozan AU - Lule KO AUID- ORCID: 0000-0003-3582-9663 AD - Department of Internal Medicine, Faculty of Medicine, Gaziantep University, 27310 Gaziantep, Turkiye. FAU - Yildiz, Hamit AU - Yildiz H AUID- ORCID: 0000-0001-7858-5123 AD - Department of Internal Medicine, Faculty of Medicine, Gaziantep University, 27310 Gaziantep, Turkiye. LA - eng PT - Journal Article PT - Observational Study DEP - 20260617 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Glycated Hemoglobin) RN - 0 (Blood Glucose) RN - 0 (hemoglobin A1c protein, human) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/blood MH - Middle Aged MH - Male MH - Female MH - *Glycated Hemoglobin/metabolism/analysis MH - Adult MH - Cross-Sectional Studies MH - *Glycemic Control MH - Food, Processed MH - Aged MH - *Blood Glucose/metabolism MH - *Fast Foods/adverse effects MH - Young Adult MH - Adolescent MH - Turkey PMC - PMC13304910 OTO - NOTNLM OT - HbA1c OT - cardiometabolic risk OT - glycemic control OT - sQ-HPF OT - type 2 diabetes mellitus OT - ultra-processed food COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 07:10 PMCR- 2026/06/17 CRDT- 2026/06/26 01:17 PHST- 2026/05/27 00:00 [received] PHST- 2026/06/11 00:00 [revised] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - nu18121951 [pii] AID - nutrients-18-01951 [pii] AID - 10.3390/nu18121951 [doi] PST - epublish SO - Nutrients. 2026 Jun 17;18(12):1951. doi: 10.3390/nu18121951. PMID- 42356324 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 15 TI - Green Tea Consumption and Risk of All-Cause Mortality: Findings from a Prospective Cohort Study. LID - 10.3390/nu18121937 [doi] LID - 1937 AB - BACKGROUND/OBJECTIVES: There has been a growing concern about excessive caffeine consumption among heavy green tea drinkers on health outcomes, such as cardiovascular diseases or cancer. We evaluated the association between green tea consumption and risk of all-cause mortality in Vietnam. METHODS: We used data from the Hanoi Prospective Cohort Study, an ongoing study comprising 42,146 participants aged 10 or older in Northern Vietnam who have been followed up between 2007 and 2019. Green tea intake was derived from a validated semi-quantitative food frequency questionnaire. We performed a Cox proportional hazard regression model to calculate the hazard ratio (HR) and respective 95% confidence intervals (95% CIs) for the association between green tea consumption and risk of all-cause mortality, adjusted for potential confounding factor. RESULTS: After a median follow-up of 11 years (range: 0.13-11.64 years), we identified 2494 deaths. Overall, there was an inverse association between green tea intake and risk of all-cause mortality (HR(perSDincrement) = 0.93; 95% CI, 0.89-0.97, P(trend) < 0.001). This pattern was more pronounced in males (HR(perSDincrement) = 0.93; 95% CI, 0.89-0.97, P(trend) < 0.001) but not in females (HR(perSDincrement) = 0.94; 95% CI, 0.86-1.02, P(trend) = 0.12; P(heterogeneity) = 0.81). In stratified analysis, the inverse association pattern was seen in both younger and old age groups, in individuals with BMI < 23 kg/m(2), in both ever and never smokers, among ever alcohol drinkers and never coffee drinkers, and in individuals with and without history of type 2 diabetes (P(heterogeneity) = 0.31). CONCLUSIONS: Findings from the current study, the first prospective cohort study in Vietnam, suggest a protective effect of green tea consumption on risk of all-cause mortality. Further studies are warranted to validate our findings in similar population and settings. FAU - Le, Ngoan Tran AU - Le NT AUID- ORCID: 0000-0001-7862-492X AD - Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam. AD - Department of Clinical Research, Vinmec Healthcare System, Hanoi 100000, Vietnam. FAU - Pham, Yen Thi-Hai AU - Pham YT AD - University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA 15232, USA. AD - Dr. Mary and Ron Neal Cancer Center, Houston Methodist Research Institute, Houston, TX 77030, USA. FAU - Nguyen, Hieu Lan AU - Nguyen HL AD - Department of Cardiovascular Diseases, Hanoi Medical University, Hanoi 100000, Vietnam. FAU - Le, Linh Thuy AU - Le LT AD - Laboratory of Embryology and Genetics of Human Malformation, Imagine Institute, INSERM UMR (National Institute of Health and Medical Research, Mixed Research Unit), 75015 Paris, France. FAU - Nguyen, Ninh Thi AU - Nguyen NT AUID- ORCID: 0009-0008-6658-8675 AD - Department of Occupational Health, Institute for Preventive Medicine and Public Health, Hanoi Medical University, Hanoi 100000, Vietnam. FAU - Vu, Thao Thu Thi AU - Vu TTT AUID- ORCID: 0009-0007-0413-3707 AD - General Daycare Inpatient Department, Hanoi Oncology Hospital, Hanoi 100000, Vietnam. FAU - Koriyama, Chihaya AU - Koriyama C AUID- ORCID: 0000-0003-3676-8866 AD - Department of Epidemiology and Preventive Medicine, Graduate School of Medical and Dental Science, Kagoshima University, Kagoshima 890-8544, Japan. FAU - Nguyen, Ha AU - Nguyen H AD - Department of Computer Science, Wayne State University, Detroit, MI 48202, USA. FAU - Nguyen, Tin C AU - Nguyen TC AUID- ORCID: 0000-0001-8001-9470 AD - Department of Industrial and Systems Engineering, Wayne State University, Detroit, MI 48202, USA. AD - Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA. FAU - Vo, Nam S AU - Vo NS AD - VinUni Big Data Research Institute, VinUniversity, Hanoi 100000, Vietnam. FAU - Wu, Lang AU - Wu L AD - LSU-LCMC Health Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA. FAU - Cullen, Jennifer AU - Cullen J AD - Dr. Mary and Ron Neal Cancer Center, Houston Methodist Research Institute, Houston, TX 77030, USA. AD - Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. FAU - Luu, Hung N AU - Luu HN AUID- ORCID: 0000-0002-2172-1849 AD - University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA 15232, USA. AD - Dr. Mary and Ron Neal Cancer Center, Houston Methodist Research Institute, Houston, TX 77030, USA. AD - Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA. LA - eng PT - Journal Article DEP - 20260615 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Tea) SB - IM MH - Humans MH - *Tea MH - Male MH - Prospective Studies MH - Female MH - Middle Aged MH - Vietnam/epidemiology MH - Risk Factors MH - Adult MH - Proportional Hazards Models MH - *Mortality MH - Adolescent MH - Young Adult MH - Child MH - Cause of Death MH - Aged PMC - PMC13304542 OTO - NOTNLM OT - Vietnam OT - all-cause mortality OT - green tea OT - prospective cohort study OT - risk COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 10:10 MHDA- 2026/06/27 07:10 PMCR- 2026/06/15 CRDT- 2026/06/26 01:17 PHST- 2026/03/31 00:00 [received] PHST- 2026/06/07 00:00 [revised] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 10:10 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - nu18121937 [pii] AID - nutrients-18-01937 [pii] AID - 10.3390/nu18121937 [doi] PST - epublish SO - Nutrients. 2026 Jun 15;18(12):1937. doi: 10.3390/nu18121937. PMID- 42356286 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 11 TI - Socio-Demographic and Anthropometric Findings of Women Caregivers in Qwa-Qwa, Free State Province, South Africa. LID - 10.3390/nu18121898 [doi] LID - 1898 AB - Background: Women remain the primary caregivers globally, especially in rural, low-resource settings plagued by poverty, unemployment, low education and poor infrastructure. These factors limit caregiving capacity, heighten vulnerability and increase the risk of food insecurity in female-headed households. Objective: To establish a baseline profile of caregivers of primary school children. Methods: Phase 1 (baseline) of the study was conducted using a quantitative, exploratory cross-sectional survey design among 75 female caregivers of children aged 7-13 years in Qwa-Qwa, Free State Province. Participants were recruited using convenience sampling. Data were collected with a structured, pre-validated questionnaire on socio-demographics, alongside anthropometric measurements. Data were analysed using descriptive statistics. Results: Most participants were unemployed (73.3%) and had low educational attainment, with 86.7% having completed primary school or less. A substantial proportion of households (80.0%) reported a monthly income below R1000. Food insecurity was common, with 69.3% of caregivers reporting experiences of food shortages. Household infrastructure was limited, particularly in refuse removal services (96.0% without access). Despite these socio-economic constraints, a high prevalence of overweight and obesity (72.5%) was observed amongst the participants. Conclusions: Caregivers experience severe, overlapping socio-economic and environmental vulnerabilities alongside a high prevalence of overweight and obesity. The study highlights the need for multi-sectoral interventions focused on poverty reduction, rural infrastructure development, improved service delivery, women's empowerment and strengthened livelihood opportunities to improve household nutrition and resilience. FAU - Mangwane, Queen E M AU - Mangwane QEM AUID- ORCID: 0000-0002-3863-4135 AD - Department of Hospitality Management, Faculty of Management Sciences, Tshwane University of Technology, Pretoria 0001, South Africa. FAU - Egal, Abdulkadir AU - Egal A AUID- ORCID: 0000-0003-0303-6319 AD - Department of Tourism & Integrated Communication, Faculty of Human Sciences, Vaal University of Technology, Vanderbijlpark 1900, South Africa. FAU - Oosthuizen, Delia AU - Oosthuizen D AUID- ORCID: 0000-0001-7570-270X AD - Department of Tourism & Integrated Communication, Faculty of Human Sciences, Vaal University of Technology, Vanderbijlpark 1900, South Africa. LA - eng PT - Journal Article DEP - 20260611 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - South Africa/epidemiology MH - *Caregivers/statistics & numerical data MH - Cross-Sectional Studies MH - Child MH - Adolescent MH - Food Insecurity MH - Anthropometry MH - Adult MH - Socioeconomic Factors MH - Poverty MH - Overweight/epidemiology MH - Middle Aged MH - Food Supply MH - Obesity/epidemiology MH - Rural Population MH - Prevalence MH - Family Characteristics MH - Surveys and Questionnaires MH - Sociodemographic Factors PMC - PMC13304777 OTO - NOTNLM OT - anthropometric status OT - malnutrition OT - socioeconomic vulnerability OT - women caregivers COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 07:10 PMCR- 2026/06/11 CRDT- 2026/06/26 01:17 PHST- 2026/04/20 00:00 [received] PHST- 2026/06/02 00:00 [revised] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/11 00:00 [pmc-release] AID - nu18121898 [pii] AID - nutrients-18-01898 [pii] AID - 10.3390/nu18121898 [doi] PST - epublish SO - Nutrients. 2026 Jun 11;18(12):1898. doi: 10.3390/nu18121898. PMID- 42356284 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 11 TI - Sex-Stratified Correlates of Pulmonary Function in Mexican Children and Adolescents (6-17 Years) with Asthma: An Exploratory Analysis of HDL Cholesterol, BMI, and Pubertal Stage. LID - 10.3390/nu18121885 [doi] LID - 1885 AB - Background/Objectives: Pubertal maturation encompasses hormonal, somatic, and metabolic alterations that may influence pulmonary function in children with asthma. We evaluated the correlates of pulmonary function in pediatric asthma using sex-stratified analyses of pubertal stage, BMI z-score, asthma control (ACQ-6), and HDL cholesterol levels on FEV1, FVC, and the FEV1/FVC ratio (% predicted, NHANES III). Methods: A cross-sectional study was conducted with 118 children and adolescents with asthma (74 males and 44 females). The Tanner stages were categorized as pre-/early (I-II), mid (III), and late (IV). No participant had reached Tanner stage V at recruitment, and the reference category was composed predominantly of Tanner II participants; therefore, the pubertal contrast reflected early- versus mid-/late-pubertal physiology rather than a strictly prepubertal-versus-pubertal comparison. We performed hierarchical linear regression with bias-corrected and accelerated bootstrap inference (5000 replicates) for each sex and for all participants combined, complemented by a formal sex x predictor interaction test. Results: Mid- and late puberty were independently associated with reduced FEV1% and FVC% (beta -0.25 to -0.31), without affecting the FEV1/FVC ratio. Sex-stratified analyses were exploratory and identified apparently divergent predictor sets by sex: in males, the pubertal stage was significant in FEV1% and FVC% (beta -0.30 to -0.42), whereas the BMI z-score diminished the FEV1/FVC ratio (beta = -0.274). In females, FEV1% was associated with HDL-c (beta = 0.463), BMI z-score (beta = 0.429), and ACQ-6 score (beta = -0.306); the female FEV1/FVC% model showed a substantial apparent effect (Cohen's f(2) = 0.508), with ACQ-6 score and HDL-c as primary associated variables. The formal sex x predictor interaction test in the combined sample, however, did not reach statistical significance (DeltaR(2) = 0.037; p = 0.178), indicating that the sex-differential patterns observed in the stratified models were not confirmed as effect modifications. Conclusions: Sex-stratified exploratory analyses in this pediatric asthma cohort identified apparently divergent patterns of associations in males and females; however, the formal interaction test was not statistically significant, indicating that these stratified differences were not confirmed and require validation in adequately powered prospective cohorts. These findings identify HDL-c, body composition, and symptom control as candidate correlates of pulmonary function, with potential sex-related differences warranting further investigation. FAU - Reyes-Noriega, Nayely AU - Reyes-Noriega N AUID- ORCID: 0000-0002-1701-7517 AD - Laboratorio de Investigacion en Alergia e Inmunologia, Hospital Infantil de Mexico Federico Gomez, Dr Marquez 162, Cuauhtemoc, Mexico City 06720, Mexico. FAU - Leija-Martinez, Jose J AU - Leija-Martinez JJ AUID- ORCID: 0000-0002-7178-1786 AD - Hospital Regional de Alta Especialidad "Dr. Ignacio Morones Prieto", IMSS-Bienestar, Av. Venustiano Carranza No. 2395, San Luis Potosi 78290, Mexico. FAU - Sanchez-Munoz, Fausto AU - Sanchez-Munoz F AUID- ORCID: 0000-0001-6556-1632 AD - Departamento de Fisiologia, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City 14080, Mexico. FAU - Hernandez-Diazcouder, Adrian AU - Hernandez-Diazcouder A AUID- ORCID: 0000-0001-6569-2851 AD - Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico. FAU - Alonso, Claudia Tavera AU - Alonso CT AD - Laboratorio Central, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City 14080, Mexico. FAU - Villafana, Santiago AU - Villafana S AUID- ORCID: 0000-0002-8660-7393 AD - Laboratorio de Terapia Genica Experimental, Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico City 11340, Mexico. FAU - Diaz, Dario Jorge Mario Molina AU - Diaz DJMM AD - Departamento de Endocrinologia, Hospital Infantil de Mexico Federico Gomez, Dr Marquez 162, Cuauhtemoc, Mexico City 06720, Mexico. FAU - Del-Rio-Navarro, Blanca E AU - Del-Rio-Navarro BE AUID- ORCID: 0000-0001-6441-8869 AD - Laboratorio de Investigacion en Alergia e Inmunologia, Hospital Infantil de Mexico Federico Gomez, Dr Marquez 162, Cuauhtemoc, Mexico City 06720, Mexico. FAU - Huang, Fengyang AU - Huang F AUID- ORCID: 0000-0002-6503-694X AD - Laboratorio de Investigacion en Obesidad y Asma, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. LA - eng GR - HIM/2021/023.SSa. 1748/Federal Government of Mexico/ GR - HIM/2022/044.SSa. 1809/Federal Government of Mexico/ GR - HIM/2023/015 SSa. 1857/Federal Government of Mexico/ GR - HIM/2024/045 SSa. 1943/Federal Government of Mexico/ PT - Journal Article DEP - 20260611 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Cholesterol, HDL) SB - IM MH - Humans MH - Child MH - Adolescent MH - Female MH - Male MH - *Asthma/physiopathology/blood MH - *Cholesterol, HDL/blood MH - Cross-Sectional Studies MH - *Body Mass Index MH - *Puberty/physiology MH - Mexico MH - Sex Factors MH - *Lung/physiopathology MH - Respiratory Function Tests MH - Forced Expiratory Volume MH - Vital Capacity PMC - PMC13305537 OTO - NOTNLM OT - FEV1 OT - FVC OT - HDL cholesterol OT - adolescents OT - asthma OT - asthma control OT - children OT - pubertal development OT - sex differences COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 07:10 PMCR- 2026/06/11 CRDT- 2026/06/26 01:17 PHST- 2026/05/08 00:00 [received] PHST- 2026/06/02 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/11 00:00 [pmc-release] AID - nu18121885 [pii] AID - nutrients-18-01885 [pii] AID - 10.3390/nu18121885 [doi] PST - epublish SO - Nutrients. 2026 Jun 11;18(12):1885. doi: 10.3390/nu18121885. PMID- 42356247 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 9 TI - Food Industry By-Products as Natural Preservatives: Supporting Adolescent Food Literacy and Critical Food Choices. LID - 10.3390/nu18121859 [doi] LID - 1859 AB - This review aims to critically examine food industry by-products as potential sources of natural preservatives and to discuss how this evidence can be translated into adolescent food literacy, label interpretation, and critical food choices. Adolescents are increasingly exposed to food labels and claims about "natural," "clean-label," "upcycled," "sustainable," and "circular" foods, which may not always be transparent or supported by sufficient evidence regarding their safety, efficacy, sensory quality, consumer acceptance, or environmental benefit. Therefore, they need more than nutritional information; they need to interpret labels, question sustainability claims, and understand how food innovations are produced, tested, communicated, and regulated. Food by-products such as fruit and vegetable pomaces, peels, seeds, skins, olive and wine residues, cereal by-products, coffee silverskin, and cocoa residues are promising resources for clean-label preservation and circular food systems because they may contain phenolics, flavonoids, carotenoids, anthocyanins, essential oils, pectin, dietary fibers, and other compounds with antioxidant, antimicrobial, coloring, stabilizing, and texturizing properties. However, the bioactive potential alone does not guarantee that a by-product-derived ingredient is safe, effective, acceptable, scalable, or sustainable. Its use requires extraction, stabilization, real-food validation, safety assessment, sensory optimization, regulatory compliance, and sustainability evaluation. The review concludes that by-product-derived natural preservatives are both technological resources and educational tools. Future research and education should connect food preservation, label interpretation, food safety, sensory quality, sustainability evidence, and consumer decision-making to empower adolescents as critical consumers and informed agents of change in sustainable food systems. FAU - Silva, Paula AU - Silva P AUID- ORCID: 0000-0001-7204-6006 AD - Department of Microscopy, School of Medicine and Biomedical Sciences (ICBAS), University of Porto (U. Porto), Rua Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal. AD - iNOVA Media Lab, ICNOVA-NOVA Institute of Communication, NOVA School of Social Sciences and Humanities, Universidade NOVA de Lisboa, 1069-061 Lisbon, Portugal. LA - eng GR - 10/C06-i07/2024.P11729/European Union/ PT - Journal Article PT - Review DEP - 20260609 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Food Preservatives) SB - IM MH - Humans MH - Adolescent MH - Food Labeling MH - *Food Preservatives MH - *Food Preferences MH - *Food Industry MH - Consumer Behavior MH - Choice Behavior PMC - PMC13304532 OTO - NOTNLM OT - adolescent food literacy OT - circular food systems OT - food industry by-products OT - food labels OT - food waste valorization OT - natural preservatives OT - sustainable food choices COIS- The author declares no conflicts of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 07:10 PMCR- 2026/06/09 CRDT- 2026/06/26 01:17 PHST- 2026/05/16 00:00 [received] PHST- 2026/06/05 00:00 [revised] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/09 00:00 [pmc-release] AID - nu18121859 [pii] AID - nutrients-18-01859 [pii] AID - 10.3390/nu18121859 [doi] PST - epublish SO - Nutrients. 2026 Jun 9;18(12):1859. doi: 10.3390/nu18121859. PMID- 42356236 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 8 TI - Feasibility and Preliminary Dietary Outcomes of the Smart Family Lifestyle Counseling Intervention in Greek Primary Care: A Single-Arm Pilot Study from Health4Eukids. LID - 10.3390/nu18121848 [doi] LID - 1848 AB - BACKGROUND: Childhood obesity is a complex public health issue in which parental perceptions and family dietary behaviors are pivotal. This study assessed the feasibility of the Smart Family lifestyle counseling intervention in Greek primary care. It explored changes in children's dietary behaviors relative to parental weight perception and Mediterranean diet adherence. METHODS: A single-arm pretest-posttest pilot study was conducted in Patras, Greece, from Health4EUKids Joint Action. The intervention consisted of four monthly face-to-face counseling sessions using the Smart Family methodology. In total, 49 parent-child dyads (aged 2-12 years) completed the program. Data collection included child anthropometric measurements, validated food frequency questionnaires, parental perception of child weight status, and parental Mediterranean diet adherence. RESULTS: Parents who underestimated their child's weight status had significantly higher Mediterranean diet scores than those who overestimated (p = 0.032); those with low adherence tended to overestimate and those with moderate adherence to underestimate. The largest reduction was observed for sweets and desserts (median -2.35 servings/week), with significant reductions in sugar-sweetened beverages, grains and cereals, whole wheat products, and dairy. Fish and vegetable intake increased significantly, but fruit intake did not change. Changes in fast food and red meat differed significantly across Mediterranean diet score tertiles, with larger decreases in the lower tertiles. CONCLUSIONS: Smart Family counseling was feasible to deliver through trained healthcare professionals in Greek primary care over four months, with reductions in selected discretionary foods observed alongside the intervention. Parental weight perception and Mediterranean diet adherence emerged as potential barriers to change although the findings are exploratory and require confirmation in a future controlled trial. FAU - Magriplis, Emmanuella AU - Magriplis E AUID- ORCID: 0000-0001-6517-6857 AD - Laboratory of Dietetics & Quality of Life, Department of Food Science and Human Nutrition, Agricultural University of Athens, 11855 Athens, Greece. AD - Laboratory of Public Health, Epidemiology and Quality of Life, Medical School, University of Patras, 26540 Patras, Greece. FAU - Myrintzou, Niki AU - Myrintzou N AD - Laboratory of Dietetics & Quality of Life, Department of Food Science and Human Nutrition, Agricultural University of Athens, 11855 Athens, Greece. FAU - Desli, Ios-Ioanna AU - Desli II AUID- ORCID: 0009-0005-5221-841X AD - Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. FAU - Papachatzi, Eleni AU - Papachatzi E AUID- ORCID: 0000-0003-4095-6827 AD - Department of Pediatrics, University General Hospital of Patras, 26504 Patras, Greece. FAU - Vantarakis, Apostolos AU - Vantarakis A AUID- ORCID: 0000-0003-4411-3739 AD - Laboratory of Public Health, Epidemiology and Quality of Life, Medical School, University of Patras, 26540 Patras, Greece. LA - eng GR - 101079944/European Health and Digital Executive Agency/ PT - Journal Article DEP - 20260608 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Pilot Projects MH - Greece MH - Male MH - Female MH - Feasibility Studies MH - Primary Health Care MH - *Counseling/methods MH - Child MH - Diet, Mediterranean MH - Child, Preschool MH - *Pediatric Obesity/prevention & control MH - *Life Style MH - Parents/psychology MH - *Feeding Behavior MH - Adult PMC - PMC13304528 OTO - NOTNLM OT - Mediterranean diet OT - Smart Family OT - childhood obesity OT - dietary behavior OT - family-based intervention OT - feasibility OT - parental perception OT - pilot study OT - primary care COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/06/26 06:38 MHDA- 2026/06/27 07:10 PMCR- 2026/06/08 CRDT- 2026/06/26 01:17 PHST- 2026/05/14 00:00 [received] PHST- 2026/06/01 00:00 [revised] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 06:38 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - nu18121848 [pii] AID - nutrients-18-01848 [pii] AID - 10.3390/nu18121848 [doi] PST - epublish SO - Nutrients. 2026 Jun 8;18(12):1848. doi: 10.3390/nu18121848. PMID- 42356232 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 8 TI - Comparing a 7-Day Food Diary and Repeated 24-Hour Dietary Recall for Estimating Usual and Operational Definitions of Acute Intake in Danish Adults. LID - 10.3390/nu18121845 [doi] LID - 1845 AB - Background: Accurate dietary assessment is essential for estimating habitual and acute exposures. This study compared a 7-day food diary (7dFD) and repeated 24-h dietary recall (2x24hDR) for habitual and acute intake. Habitual fish and n-3 PUFA estimates were evaluated against whole-blood EPA and DHA, and acute intake of fish, rye bread, and coffee was explored using operational indicators. Methods: In a within-subject comparative design, 120 Danish adults aged 18-60 years completed both methods. Fish and n-3 fatty acid intakes were compared with whole-blood EPA and DHA. Usual fish intake from 2x24hDR was estimated using the Multiple Source Method (MSM) with Food Propensity Questionnaire (FPQ) data. Acute intake was assessed using single-day, consumption-day, single-meal, maximum-day, and meal-weighted estimates. Results: EPA, DHA, total fish, and fatty fish intakes estimated from the 7dFD and MSM-adjusted 2x24hDR correlated with biomarkers r = 0.23-0.46. Supplement inclusion improved EPA and DHA correlations (r = 0.26-0.59). The unadjusted 2x24hDR identified fewer fish consumers than the 7dFD (63% vs. 88%), whereas FPQ-based modelling identified 97%. Acute intake estimates varied by method and definition: the 2x24hDR produced higher short-term and upper- percentile estimates, while the 7dFD produced more stable distributions. Limitations include modest sample size, upper-percentile uncertainty, and non-equivalent supplement assessment. Conclusions: In this adult convenience sample, the 7dFD provided more stable habitual intake estimates, whereas the 2x24hDR produced higher short-term and upper-percentile estimates under the applied operational acute-intake definitions. These findings are context-dependent and should not be taken as evidence that either method is generally superior. FAU - Biltoft-Jensen, Anja AU - Biltoft-Jensen A AUID- ORCID: 0000-0002-6607-7575 AD - National Food Institute, Technical University of Denmark, 2800 Kongens Lyngby, Denmark. FAU - Aristizabal-Henao, Juan J AU - Aristizabal-Henao JJ AUID- ORCID: 0000-0002-2085-2396 AD - BPGbio, BPGbio Inc., Waltham, MA 02451, USA. AD - Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON N2L 3G1, Canada. FAU - Stark, Ken D AU - Stark KD AUID- ORCID: 0000-0001-7828-4072 AD - Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON N2L 3G1, Canada. FAU - Christensen, Tue AU - Christensen T AUID- ORCID: 0000-0001-7693-7359 AD - National Food Institute, Technical University of Denmark, 2800 Kongens Lyngby, Denmark. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260608 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 25167-62-8 (Docosahexaenoic Acids) RN - AAN7QOV9EA (Eicosapentaenoic Acid) RN - 0 (Fatty Acids, Omega-3) SB - IM MH - Humans MH - Adult MH - *Diet Records MH - Middle Aged MH - Male MH - Female MH - Denmark MH - Young Adult MH - Adolescent MH - *Mental Recall MH - *Diet MH - Docosahexaenoic Acids/blood/administration & dosage MH - Fishes MH - Eicosapentaenoic Acid/blood/administration & dosage MH - Seafood MH - Animals MH - Nutrition Assessment MH - *Feeding Behavior MH - Fatty Acids, Omega-3/blood/administration & dosage PMC - PMC13306161 OTO - NOTNLM OT - 24-h dietary recall OT - 7-day food diary OT - DHA OT - EPA OT - acute dietary intake OT - dietary assessment OT - fish intake OT - usual dietary intake OT - validation OT - whole-blood biomarkers COIS- K.S. is on the Board of Directors of the International Society for the Study of Fatty Acids and Lipids (ISSFAL). J.J.A.-H. completed this research at the University of Waterloo during his Ph.D. and currently works for BPGbio Inc., a company that provides lipidomic analyses. The company and the Board of Directors of ISSFAL had no role in the design of the study; in data collection, in analysis, or interpretation; in the writing of the manuscript; or in the decision to publish. A.B. and T.C declare no conflicts of interest. EDAT- 2026/06/26 06:38 MHDA- 2026/06/27 07:41 PMCR- 2026/06/08 CRDT- 2026/06/26 01:17 PHST- 2026/04/01 00:00 [received] PHST- 2026/05/27 00:00 [revised] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/06/27 07:41 [medline] PHST- 2026/06/26 06:38 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - nu18121845 [pii] AID - nutrients-18-01845 [pii] AID - 10.3390/nu18121845 [doi] PST - epublish SO - Nutrients. 2026 Jun 8;18(12):1845. doi: 10.3390/nu18121845. PMID- 42355722 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 12 DP - 2026 Jun 12 TI - Concordance Between Anthropometric Formula Predictions and Chest Radiograph-Confirmed Endotracheal Tube Depth in Young Infants: A Retrospective Cohort Study from Saudi Arabia. LID - 10.3390/jcm15124554 [doi] LID - 4554 AB - Background: Accurate endotracheal tube (ETT) insertion depth is critical in infants and young children, where tracheal malposition carries significant risk. Formula-based depth estimation is widely used at the bedside, but the performance of published formulas in children under two years of age admitted to a general PICU remains poorly characterized. Methods: A retrospective, single-center study was conducted at the PICU of King Saud Medical City, Riyadh. A total of 115 patients aged 1-24 months requiring orotracheal intubation were included. ETT depth was predicted using five established formulas: height-based [(H/10)+5], weight-based [W+6], ETT size-based [ETTx3], Lee weight-based [5.5+0.5W], and Lee height-based [3+0.1H]. Agreement between predicted and radiographically confirmed insertion depth was assessed using Lin's concordance correlation coefficient (CCC), Bland-Altman analysis, and clinical classification of predictions. Results: None of the five formulas achieved acceptable concordance (CCC < 0.75 for all). The height-based formula performed best among published formulas, with negligible bias and the highest proportion of clinically acceptable predictions. Both Lee formulas showed near-universal systematic underestimation and are not suitable for this age group. Over half of all intubations resulted in non-ideal ETT position on the first post-intubation chest X-ray. Novel cohort-derived regression equations outperformed all published formulas, with the weight-based equation (Depth = 0.385 x Weight + 9.145) emerging as the strongest predictor of insertion depth. Conclusions: No published formula achieved reliable concordance with radiographic ETT depth in children aged 1-24 months. The cohort-derived weight-based formula represents a more accurate bedside tool for this population and warrants prospective external validation. Post-intubation radiographic verification remains essential. FAU - Mavrych, Volodymyr AU - Mavrych V AUID- ORCID: 0009-0009-1159-4573 AD - College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia. FAU - Majeed, Kashif AU - Majeed K AUID- ORCID: 0009-0007-0870-639X AD - Pediatric Intensive Care Unit, King Saud Medical City, Riyadh 12746, Saudi Arabia. FAU - Alshehri, Saleh AU - Alshehri S AUID- ORCID: 0009-0001-0388-5102 AD - Pediatric Intensive Care Unit, King Saud Medical City, Riyadh 12746, Saudi Arabia. FAU - Yasmin, Uzma AU - Yasmin U AUID- ORCID: 0009-0007-0147-8814 AD - Pediatric Emergency, King Saud University, Riyadh 11451, Saudi Arabia. FAU - Kashif, Muhammad Rayyan AU - Kashif MR AUID- ORCID: 0009-0004-1665-6888 AD - College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia. FAU - Kashif, Ayesha AU - Kashif A AUID- ORCID: 0009-0001-6208-2131 AD - College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia. FAU - Mahdi, Warda AU - Mahdi W AUID- ORCID: 0009-0006-7040-8222 AD - College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia. FAU - Talha, Raghd AU - Talha R AUID- ORCID: 0009-0008-1238-8213 AD - College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia. FAU - Bolgova, Olena AU - Bolgova O AUID- ORCID: 0009-0002-9496-9754 AD - College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260612 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13301687 OTO - NOTNLM OT - concordance correlation coefficient OT - endotracheal tube OT - insertion depth OT - intensive care OT - pediatric intubation COIS- The authors declare no conflicts of interest, financial or otherwise. EDAT- 2026/06/26 13:10 MHDA- 2026/06/26 13:11 PMCR- 2026/06/12 CRDT- 2026/06/26 01:15 PHST- 2026/05/06 00:00 [received] PHST- 2026/05/29 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/06/26 13:11 [medline] PHST- 2026/06/26 13:10 [pubmed] PHST- 2026/06/26 01:15 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - jcm15124554 [pii] AID - jcm-15-04554 [pii] AID - 10.3390/jcm15124554 [doi] PST - epublish SO - J Clin Med. 2026 Jun 12;15(12):4554. doi: 10.3390/jcm15124554. PMID- 42354516 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 12 DP - 2026 Jun 11 TI - Associations of Physical Fitness and Postural Balance with Psychosocial Well-Being in Early Adolescents: A School-Based Cross-Sectional Study. LID - 10.3390/healthcare14121659 [doi] LID - 1659 AB - Objective: This study aimed to examine the associations of morphological variables, maximal isometric handgrip strength (MIHS), and static postural balance with self-esteem, motivational climate, school climate, and health-related quality of life (HRQoL) in early adolescents. Methods: A cross-sectional study was conducted in 235 Chilean adolescents, in whom morphological variables, MIHS, and static postural balance were assessed using center-of-pressure (CoP) parameters under eyes-open (EO) and eyes-closed (EC) conditions. Psychosocial variables, including self-esteem, motivational climate, school climate, and HRQoL, were evaluated via validated questionnaires. Multiple linear regression analyses were performed to determine associations between physical and psychosocial variables. Results: Reduced CoP sway area and lower CoP velocity under eyes-closed conditions were significantly associated with higher self-esteem (R(2) = 0.168; p < 0.001). Greater non-dominant MIHS and younger age were associated with more favorable perceptions of a task-involving motivational climate (R(2) = 0.438; p < 0.001). Higher HRQoL scores were associated with male sex and better postural balance performance. Conclusions: Better static postural balance and greater muscle strength were associated with more favorable psychosocial outcomes, particularly self-esteem and HRQoL. However, these findings should be interpreted as associative rather than causal relationships due to the cross-sectional design. FAU - Aristegui-Mondaca, Juan AU - Aristegui-Mondaca J AD - Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca 3530000, Chile. AD - Master Program of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca 3530000, Chile. FAU - Rodriguez Sepulveda, Gabriel AU - Rodriguez Sepulveda G AD - Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca 3530000, Chile. FAU - Guzman-Munoz, Eduardo AU - Guzman-Munoz E AUID- ORCID: 0000-0001-7001-9004 AD - School of Kinesiology, Faculty of Health, Universidad Santo Tomas, Talca 3460000, Chile. AD - School of Physical Education Pedagogy, Faculty of Education, Universidad Autonoma de Chile, Talca 3460000, Chile. FAU - Hernandez-Martinez, Jordan AU - Hernandez-Martinez J AD - Department of Physical Activity Sciences, Universidad de Los Lagos, Osorno 5290000, Chile. AD - Department of Education, Faculty of Humanities, Universidad de la Serena, La Serena 1700000, Chile. FAU - Perez-Carcamo, Joaquin AU - Perez-Carcamo J AUID- ORCID: 0009-0006-0224-3745 AD - Department of Physical Activity Sciences, Universidad de Los Lagos, Osorno 5290000, Chile. FAU - Vasquez-Carrasco, Edgar AU - Vasquez-Carrasco E AUID- ORCID: 0000-0002-5359-6587 AD - School of Occupational Therapy, Faculty of Psychology, Universidad de Talca, Talca 3465548, Chile. AD - Centro de Investigacion en Ciencias Cognitivas, Faculty of Psychology, Universidad de Talca, Talca 3465548, Chile. FAU - Merellano-Navarro, Eugenio AU - Merellano-Navarro E AUID- ORCID: 0000-0002-1557-2285 AD - Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca 3530000, Chile. FAU - Magnani Branco, Braulio Henrique AU - Magnani Branco BH AUID- ORCID: 0000-0002-4625-9128 AD - Graduate Program in Health Promotion, Cesumar University (UniCesumar), Maringa 87050-900, Brazil. FAU - Carmine-Pena, Eduardo AU - Carmine-Pena E AD - Carrera de Medicina, Facultad de Medicina, Universidad de La Frontera, Temuco 4811230, Chile. FAU - Sandoval-Vasquez, Cristian AU - Sandoval-Vasquez C AUID- ORCID: 0000-0003-3184-6482 AD - Carrera de Terapia Ocupacional, Facultad de Ciencias de la Salud, Universidad Autonoma de Chile, Temuco 4810101, Chile. AD - Departamento de Medicina Interna, Facultad de Medicina, Universidad de La Frontera, Temuco 4811230, Chile. FAU - Pena, Francisca AU - Pena F AD - Departamento de Medicina Interna, Facultad de Medicina, Universidad de La Frontera, Temuco 4811230, Chile. FAU - Valdes-Badilla, Pablo AU - Valdes-Badilla P AUID- ORCID: 0000-0002-3948-8280 AD - Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca 3530000, Chile. AD - Sports Coach Career, Faculty of Life Sciences, Universidad Vina del Mar, Vina del Mar 2520000, Chile. LA - eng GR - 11220035/Fondo Nacional de Desarrollo Cientifico y Tecnologico/ PT - Journal Article DEP - 20260611 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13300289 OTO - NOTNLM OT - body composition OT - motivation OT - muscle strength OT - proprioception OT - psychological well-being OT - self-concept COIS- The authors declare that they have no conflicts of interest. EDAT- 2026/06/26 06:40 MHDA- 2026/06/26 06:41 PMCR- 2026/06/11 CRDT- 2026/06/26 01:11 PHST- 2026/04/16 00:00 [received] PHST- 2026/05/25 00:00 [revised] PHST- 2026/05/26 00:00 [accepted] PHST- 2026/06/26 06:41 [medline] PHST- 2026/06/26 06:40 [pubmed] PHST- 2026/06/26 01:11 [entrez] PHST- 2026/06/11 00:00 [pmc-release] AID - healthcare14121659 [pii] AID - healthcare-14-01659 [pii] AID - 10.3390/healthcare14121659 [doi] PST - epublish SO - Healthcare (Basel). 2026 Jun 11;14(12):1659. doi: 10.3390/healthcare14121659. PMID- 42354335 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20261024 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 23 IP - 6 DP - 2026 Jun 17 TI - Association Between Physical Activity, Body Mass Index, and Aerobic Capacity in Periurban Adolescents. LID - 10.3390/ijerph23060806 [doi] LID - 806 AB - Adolescence is a critical window for health behavior consolidation, yet the combined influence of physical activity level (PAL) and the body mass index (BMI) on aerobic capacity remains understudied, especially in transitioning periurban environments. This study examined the association between PAL, BMI, and aerobic capacity in adolescents from Monteria, Colombia. A cross-sectional study was conducted among 112 adolescents (aged 12-17 years). Aerobic capacity was assessed using the 20 m shuttle run test (Course Navette), and PAL was measured via the validated Assessment of Physical Activity Levels Questionnaire (APALQ), following standard fitness assessment protocols. Multivariable linear regression models were utilized to estimate independent associations, adjusting for age and sex. The multivariable model was significant (F = 8.45; p < 0.001), explaining 21% of the variance in aerobic capacity (adjusted R(2) = 0.21). PAL was positively and independently associated with aerobic capacity (B = 0.22; 95% CI: 0.05-0.38; p = 0.010), regardless of BMI. While age showed a positive association (B = 0.09; p = 0.032) and sex was inversely associated (B = -0.39; p < 0.001), BMI did not emerge as an independent predictor in the adjusted model (B = -0.04; p = 0.080). Aerobic capacity in adolescents is more consistently explained by behavioral factors (what they "do") than by anthropometric status (what they "weigh"). These findings support a paradigm shift in pediatric public health, prioritizing high-intensity movement overweight control to improve cardiorespiratory fitness in transitioning urban territories. FAU - Sepulveda, Fabian AU - Sepulveda F AUID- ORCID: 0000-0002-2715-3184 AD - Programa de Maestria en Epidemiologia de la, Universidad del Sinu-Elias Bechara Zainum, Monteria 230001, Colombia. FAU - Penata-Taborda, Ana AU - Penata-Taborda A AUID- ORCID: 0000-0001-8698-612X AD - Grupo de Investigacion Biomedica y Biologia Molecular, Universidad del Sinu-Elias Bechara Zainum, Monteria 230001, Colombia. FAU - Bru-Cordero, Osnamir AU - Bru-Cordero O AUID- ORCID: 0000-0001-9425-9475 AD - Direccion Academica, Universidad Nacional de Colombia Sede de La Paz, Cesar 200017, Colombia. FAU - Montoya-Alvarez, Leily AU - Montoya-Alvarez L AUID- ORCID: 0000-0002-3806-7986 AD - Grupo de Investigacion MOSABI, Universidad del Sinu-Elias Bechara Zainum, Monteria 230001, Colombia. FAU - Humanez-Alvarez, Alicia AU - Humanez-Alvarez A AUID- ORCID: 0000-0002-3114-6235 AD - Grupo de Investigacion Biomedica y Biologia Molecular, Universidad del Sinu-Elias Bechara Zainum, Monteria 230001, Colombia. LA - eng PT - Journal Article DEP - 20260617 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - *Body Mass Index MH - Adolescent MH - Female MH - Male MH - Cross-Sectional Studies MH - Child MH - *Exercise MH - Colombia MH - *Cardiorespiratory Fitness MH - *Physical Fitness PMC - PMC13299683 OTO - NOTNLM OT - behavioral determinants and multivariable analysis OT - cardiorespiratory fitness OT - nutritional status OT - periurban health COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; the collection, analyses, or interpretation of data; the writing of the manuscript; or the decision to publish the results. EDAT- 2026/06/26 13:10 MHDA- 2026/06/27 04:10 PMCR- 2026/06/17 CRDT- 2026/06/26 01:10 PHST- 2025/12/15 00:00 [received] PHST- 2026/03/02 00:00 [revised] PHST- 2026/03/17 00:00 [accepted] PHST- 2026/06/27 04:10 [medline] PHST- 2026/06/26 13:10 [pubmed] PHST- 2026/06/26 01:10 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - ijerph23060806 [pii] AID - ijerph-23-00806 [pii] AID - 10.3390/ijerph23060806 [doi] PST - epublish SO - Int J Environ Res Public Health. 2026 Jun 17;23(6):806. doi: 10.3390/ijerph23060806. PMID- 42354263 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 23 IP - 6 DP - 2026 May 30 TI - Psychological Distress and Associated Factors Among High-School Students in Makkah, Saudi Arabia: A Cross-Sectional Study Using the Arabic GHQ-30. LID - 10.3390/ijerph23060733 [doi] LID - 733 AB - BACKGROUND: Mental health problems often begin in adolescence, yet early detection and intervention remain limited. This study assesses the prevalence of psychological distress and its correlates among high-school students in Makkah, Saudi Arabia, and explores whether specific symptom clusters of depression, anxiety and bipolar/mania can be identified using the General Health Questionnaire-30 (GHQ-30). METHODS: A cross-sectional survey was conducted during the 2025-2026 academic year using stratified cluster sampling. A total of 535 students aged 15-18 years completed a questionnaire containing the validated Arabic GHQ-30 and demographic, socioeconomic and lifestyle items. The GHQ-30 was scored with binary 0-0-1-1 scoring (cut-off >/= 6) to define cases of psychological distress. Item clusters were used to screen for probable depression, anxiety and bipolar/mania. Descriptive statistics characterized the sample. Associations were examined using chi-square tests and multivariable logistic regression. RESULTS: Overall, 70.5% of participants screened positive for psychological distress. The prevalences of probable depression, anxiety and bipolar/mania were 33.1%, 28.2% and 31.2%, respectively. In adjusted models, female gender, insufficient sleep, lack of physical activity and exposure to bullying were associated with increased odds of psychological distress; longer sleep was protective. History of mental health conditions was a strong predictor of probable depression, whereas medication use was protective. Older age and higher paternal education were protective for anxiety. Bullying was the most consistent predictor across all symptom clusters. CONCLUSIONS: Psychological distress is highly prevalent among Makkah high-school students. Key determinants include gender, sleep duration, lack of physical activity and bullying. Routine school-based mental health screening, sleep-hygiene education, anti-bullying initiatives and early referral pathways are warranted. Further research should examine and validate GHQ-30 item clusters for specific disorders. FAU - Hashim, Arwa Hesham AU - Hashim AH AD - Saudi Board Program of Preventive Medicine, Program, Makkah Health Cluster, Makkah 24242, Saudi Arabia. FAU - Khan, Adeel Ahmed AU - Khan AA AUID- ORCID: 0000-0003-2724-8113 AD - Saudi Board Program of Preventive Medicine, Program, Makkah Health Cluster, Makkah 24242, Saudi Arabia. FAU - Hayat, Aalia Akhtar AU - Hayat AA AUID- ORCID: 0000-0001-6609-0879 AD - Department of Child Psychiatry, Maternity and Children Hospital, Makkah Health Cluster, Makkah 24242, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260530 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Adolescent MH - Cross-Sectional Studies MH - Female MH - *Students/psychology/statistics & numerical data MH - Male MH - *Psychological Distress MH - Surveys and Questionnaires MH - Prevalence MH - *Stress, Psychological/epidemiology MH - Depression/epidemiology PMC - PMC13299696 OTO - NOTNLM OT - GHQ-30 OT - Saudi Arabia OT - adolescent mental health OT - bullying OT - cross-sectional study OT - high-school students OT - physical activity OT - psychological distress OT - school-based screening OT - sleep duration COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 06:38 MHDA- 2026/06/27 07:10 PMCR- 2026/05/30 CRDT- 2026/06/26 01:10 PHST- 2026/04/20 00:00 [received] PHST- 2026/05/22 00:00 [revised] PHST- 2026/05/26 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 06:38 [pubmed] PHST- 2026/06/26 01:10 [entrez] PHST- 2026/05/30 00:00 [pmc-release] AID - ijerph23060733 [pii] AID - ijerph-23-00733 [pii] AID - 10.3390/ijerph23060733 [doi] PST - epublish SO - Int J Environ Res Public Health. 2026 May 30;23(6):733. doi: 10.3390/ijerph23060733. PMID- 42354229 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 23 IP - 6 DP - 2026 May 25 TI - Prevalence, Risk Factors, and Preventive Strategies of Hypertension Among Young Adults in the United Arab Emirates. LID - 10.3390/ijerph23060698 [doi] LID - 698 AB - Background: Hypertension is one of the most common noncommunicable diseases. Objectives: This research assessed the magnitude of hypertension among young adults, identified its key determinants, and explored potential strategies adopted for prevention. Methods: A cross-sectional design was employed, including 1606 participants aged 18 years and older, recruited through convenience sampling from universities and community settings. Data were collected using a content-validated questionnaire covering sociodemographic information, personal and family medical history, and lifestyle habits. Results: Of the participants, 993 (61.8%) reported hypertension, nearly double previous national estimates. Male gender, age >/= 30 years, and family history were significant risk factors, along with smoking, alcohol use, sedentary lifestyle, and unhealthy diet, while physical activity and dietary modification were protective. Despite high prevalence, only 22.1% had controlled blood pressure and 17.8% adhered to medication, with 51.5% relying on herbal remedies. Conclusions: These findings highlight the urgent need for early screening, youth-focused awareness, and culturally tailored interventions to reduce hypertension and prevent long-term cardiovascular complications. Hypertension among young adults in the UAE is a major public health concern, requiring integrated strategies combining education, lifestyle modification, and medical management to improve outcomes. FAU - Raid Hussain Aljubori, Aws AU - Raid Hussain Aljubori A AD - Community Medicine, College of Medicine, Gulf Medical University, Ajman P.O. Box 4184, United Arab Emirates. FAU - Abutartour, Mahmoud Nabil M AU - Abutartour MNM AD - Community Medicine, College of Medicine, Gulf Medical University, Ajman P.O. Box 4184, United Arab Emirates. FAU - Abdulla Darwish Ali, Ibrahim AU - Abdulla Darwish Ali I AD - Community Medicine, College of Medicine, Gulf Medical University, Ajman P.O. Box 4184, United Arab Emirates. FAU - Ghaith Al Haj Younes, Mohammed AU - Ghaith Al Haj Younes M AD - Community Medicine, College of Medicine, Gulf Medical University, Ajman P.O. Box 4184, United Arab Emirates. FAU - Muttappallymyalil, Jayakumary AU - Muttappallymyalil J AD - Community Medicine, College of Medicine, Gulf Medical University, Ajman P.O. Box 4184, United Arab Emirates. LA - eng PT - Journal Article DEP - 20260525 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - *Hypertension/epidemiology/prevention & control/etiology MH - Male MH - Female MH - Risk Factors MH - United Arab Emirates/epidemiology MH - Prevalence MH - Young Adult MH - Cross-Sectional Studies MH - Adult MH - Adolescent MH - Life Style MH - Surveys and Questionnaires PMC - PMC13299299 OTO - NOTNLM OT - UAE OT - hypertension OT - prevalence OT - preventive practices OT - young adults COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 04:10 PMCR- 2026/05/25 CRDT- 2026/06/26 01:10 PHST- 2026/04/14 00:00 [received] PHST- 2026/05/05 00:00 [revised] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/06/27 04:10 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:10 [entrez] PHST- 2026/05/25 00:00 [pmc-release] AID - ijerph23060698 [pii] AID - ijerph-23-00698 [pii] AID - 10.3390/ijerph23060698 [doi] PST - epublish SO - Int J Environ Res Public Health. 2026 May 25;23(6):698. doi: 10.3390/ijerph23060698. PMID- 42353995 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 6 DP - 2026 Jun 17 TI - Physical Activity as a Mediator of the Relationship Between Mediterranean Diet Adherence and Anxiety Symptoms in Chilean Adolescents: A Cross-Sectional Study. LID - 10.3390/children13060825 [doi] LID - 825 AB - BACKGROUND: Adolescent mental health is a global concern, with lifestyle factors such as diet and physical activity (PA) playing a crucial role. While the Mediterranean Diet adherence (MDA) is known for its neuroprotective benefits on mental health, the mechanisms by which they are related remain unclear. Therefore, the aim of this study was twofold: (1) to examine the associations between MDA, PA, and screen time (ST) with anxiety symptoms, depression, stress, and total psychological distress in Chilean adolescents; and (2) to determine whether PA mediates the relationship between MDA and anxiety symptoms. METHODS: A cross-sectional study was conducted with 322 Chilean school-aged adolescents 158 males and 164 females (14.98 +/- 1.96 years). Mental health outcomes (depression, anxiety, and stress) and lifestyle behaviors, including MDA, PA, and ST, were comprehensively assessed using validated self-reported questionnaires. RESULTS: After adjusting for age and sex, multiple linear regression models showed that higher MDA was significantly and inversely associated with anxiety (b = -0.23, p = 0.044), stress (b = -0.25, p = 0.022), and total psychological distress (b = -0.72, p = 0.022). Conversely, ST was identified as a consistent risk factor, positively predicting higher levels of anxiety (b = 0.45, p = 0.008), stress (b = 0.42, p = 0.008), and total distress (b = 1.11, p = 0.014). Furthermore, PA was inversely linked to anxiety (b = -0.35, p = 0.013) and successfully mediated the relationship between MDA and anxiety symptoms (Indirect Effect = -0.047, 95% CI: -0.10 to -0.01). No significant mediation effects were observed for depression or stress. CONCLUSIONS: The present study identifies robust inverse associations between MDA and symptoms of anxiety, depression, and stress in Chilean adolescents. A key finding is the specific pattern of relationships observed: while higher MDA is directly linked to lower levels of depression and stress, its association with anxiety is shared with levels of PA. Despite these findings, the cross-sectional nature of the study limits the establishment of causal relationships, and further longitudinal research is needed to confirm these directional pathways. FAU - Caamano-Navarrete, Felipe AU - Caamano-Navarrete F AUID- ORCID: 0000-0002-6884-589X AD - Physical Education Career, Universidad Autonoma de Chile, Temuco 4780000, Chile. FAU - Hernandez-Mosqueira, Claudio AU - Hernandez-Mosqueira C AUID- ORCID: 0000-0001-9392-2319 AD - Departamento de Ciencias de la Educacion, Universidad del Bio-Bio, Chillan 3780000, Chile. FAU - Contreras-Diaz, Guido AU - Contreras-Diaz G AD - Escuela de Kinesiologia, Facultad de Ciencias de la Rehabilitacion y Calidad de Vida, Universidad San Sebastian, Lago Panguipulli 1390, Puerto Montt 5501842, Chile. FAU - Del-Cuerpo, Indya AU - Del-Cuerpo I AUID- ORCID: 0000-0002-2949-7896 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, 18071 Granada, Spain. FAU - Jerez-Mayorga, Daniel AU - Jerez-Mayorga D AUID- ORCID: 0000-0002-6878-8004 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, 18071 Granada, Spain. AD - Exercise and Rehabilitation Sciences Institute, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7591538, Chile. FAU - Herrera-Valenzuela, Tomas AU - Herrera-Valenzuela T AUID- ORCID: 0000-0002-5219-5896 AD - Department of Physical Activity, Sports and Health Sciences, Faculty of Medical Sciences, Universidad de Santiago de Chile (USACH), Santiago 8370003, Chile. FAU - Guzman-Munoz, Eduardo AU - Guzman-Munoz E AUID- ORCID: 0000-0001-7001-9004 AD - School of Kinesiology, Faculty of Health, Universidad Santo Tomas, Talca 3460000, Chile. FAU - Hernandez-Martinez, Jordan AU - Hernandez-Martinez J AD - Department of Physical Activity Sciences, Universidad de Los Lagos, Osorno 5290000, Chile. AD - Department of Education, Faculty of Humanities, Universidad de la Serena, La Serena 1700000, Chile. FAU - Valdes-Badilla, Pablo AU - Valdes-Badilla P AUID- ORCID: 0000-0002-3948-8280 AD - Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca 3460000, Chile. AD - Sports Coach Career, Faculty of Life Sciences, Universidad Vina del Mar, Vina del Mar 2520000, Chile. FAU - Nunez-Espinosa, Cristian AU - Nunez-Espinosa C AUID- ORCID: 0000-0002-9896-7062 AD - Escuela de Medicina, Universidad de Magallanes, Punta Arenas 6200000, Chile. AD - Centro Asistencial Docente y de Investigacion, Universidad de Magallanes, Punta Arenas 6200000, Chile. AD - Red Interuniversitaria de Envejecimiento Saludable de Latinoamerica y Caribe (RIES-LAC), Punta Arenas 6200000, Chile. FAU - Delgado-Floody, Pedro AU - Delgado-Floody P AUID- ORCID: 0000-0001-9952-993X AD - Department of Physical Education, Sport and Recreation, Universidad de La Frontera, Temuco 4811230, Chile. LA - eng PT - Journal Article DEP - 20260617 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13298326 OTO - NOTNLM OT - adolescents OT - anxiety OT - depression OT - mediation analysis OT - mediterranean diet OT - mental health OT - physical activity COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 13:10 MHDA- 2026/06/26 13:11 PMCR- 2026/06/17 CRDT- 2026/06/26 01:09 PHST- 2026/04/30 00:00 [received] PHST- 2026/06/08 00:00 [revised] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/06/26 13:11 [medline] PHST- 2026/06/26 13:10 [pubmed] PHST- 2026/06/26 01:09 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - children13060825 [pii] AID - children-13-00825 [pii] AID - 10.3390/children13060825 [doi] PST - epublish SO - Children (Basel). 2026 Jun 17;13(6):825. doi: 10.3390/children13060825. PMID- 42352833 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 6 DP - 2026 Jun 15 TI - Daily Routines and Habits in Individuals with Attention Deficit Hyperactivity Disorder: A Scoping Review. LID - 10.3390/bs16061000 [doi] LID - 1000 AB - This scoping review examined the current literature on routines and habits in individuals with attention deficit hyperactivity disorder (ADHD). To our knowledge, research in this area remains limited. Therefore, this review mapped which areas of daily routines are most affected in children and adults with ADHD and explored related assessments and interventions. A comprehensive search was conducted across four databases: PubMed, Scopus, CINAHL, and PsycINFO, using keywords including "attention deficit hyperactivity disorder," "ADHD," "routine," "habit," and "lifestyle." The findings identified four main domains in which individuals with ADHD experience difficulties: sleep hygiene, feeding, physical activity, and sedentary behaviors, with sleep hygiene addressed in more than half of the included studies. Study habits were addressed in only one included study. Among the 31 included studies, six involved interventions. The review also found that no validated assessment was specifically designed to measure routines or habits in individuals with ADHD, and that broader measures of routines, habits, or lifestyle were often non-validated or developed for a single project. Overall, the existing studies were concentrated primarily in pediatric populations, with limited research involving adults. These findings highlight important gaps in the literature and underscore the need for more research on routines and habits in adults with ADHD. They also support the development of assessments and interventions that specifically address these areas. FAU - Almudayfir, Ibrahim AU - Almudayfir I AD - Occupational Therapy Department, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh 1148, Saudi Arabia. AD - Rehabilitation Science Program, University of Alabama at Birmingham, Birmingham, AL 35294, USA. FAU - Abdulkarim, Lama AU - Abdulkarim L AD - Independent Researcher, Riyadh 13343, Saudi Arabia. FAU - Rosenstein, Rachael AU - Rosenstein R AD - Outreach Therapy, Pittsburgh, PA 15213, USA. FAU - Yuen, Hon K AU - Yuen HK AUID- ORCID: 0000-0001-5696-1845 AD - Department of Occupational Therapy, University of Alabama at Birmingham, Birmingham, AL 35294, USA. LA - eng PT - Journal Article PT - Review DEP - 20260615 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13295911 OTO - NOTNLM OT - ADHD OT - habit OT - lifestyle OT - routine OT - scoping review COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 13:10 MHDA- 2026/06/26 13:11 PMCR- 2026/06/15 CRDT- 2026/06/26 01:05 PHST- 2026/02/22 00:00 [received] PHST- 2026/05/07 00:00 [revised] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/06/26 13:11 [medline] PHST- 2026/06/26 13:10 [pubmed] PHST- 2026/06/26 01:05 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - bs16061000 [pii] AID - behavsci-16-01000 [pii] AID - 10.3390/bs16061000 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Jun 15;16(6):1000. doi: 10.3390/bs16061000. PMID- 42352707 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 6 DP - 2026 Jun 1 TI - Predicting Intrinsic Motivation After an Adventure Education Program in Primary Schools: Enjoyment, Self-Confidence and Resilience According to Gender. LID - 10.3390/bs16060874 [doi] LID - 874 AB - This study aimed to describe the pre-post changes in intrinsic motivation observed following the implementation of a parkour-based Adventure Education (AE) program in primary school students, and to examine the role of enjoyment, self-confidence, and resilience as variables statistically associated with intrinsic motivation, considering differences according to time (pre-test-post-test) and gender. The sample consisted of 492 fifth- and sixth-grade primary education students (249 boys and 243 girls) with a mean age of 10.67 years, enrolled in 12 Spanish schools. A quasi-experimental design with pre-test and post-test measures was used following the implementation of a seven-session program based on the Pedagogical Model of Adventure Education. Data were collected using instruments validated in the Spanish population: the intrinsic motivation subscale of the Perceived Locus of Causality Scale, the Physical Activity Enjoyment Scale to measure enjoyment, the self-confidence subscale of the Competitive State Anxiety Inventory, and the Connor-Davidson Resilience Scale to assess resilience. Statistical analysis was performed using SPSS 28.0 software, conducting descriptive analyses, correlations, and hierarchical multiple linear regressions to examine the statistical associations among the variables at each measurement point, along with a 2 x 2 repeated-measures ANOVA (time x gender). Post-test scores were significantly higher than pre-test scores for intrinsic motivation, enjoyment, self-confidence and resilience. Enjoyment was the variable most strongly statistically associated with intrinsic motivation, followed by self-confidence and resilience. The ANOVA showed a significant main effect of time, while no significant time x gender interaction was detected, meaning that the study found no evidence that the pre-post change differed between boys and girls. Given the single-arm pre-post design and the absence of a control group, these findings should be interpreted as preliminary descriptive evidence of pre-post change and associations, and not as a causal test of the program's effectiveness. FAU - Calmaestra-Sanchez, Andres AU - Calmaestra-Sanchez A AUID- ORCID: 0000-0001-6916-2284 AD - Department of Didactics of Musical, Plastic and Bodily Expression, University of Granada, 18015 Granada, Spain. FAU - Baena-Extremera, Antonio AU - Baena-Extremera A AUID- ORCID: 0000-0002-3597-4038 AD - Department of Didactics of Musical, Plastic and Bodily Expression, University of Granada, 18015 Granada, Spain. FAU - Gonzalez-Ruiz, Josue AU - Gonzalez-Ruiz J AUID- ORCID: 0000-0003-4977-9433 AD - Department of Didactics of Musical, Plastic and Bodily Expression, University of Granada, 18015 Granada, Spain. FAU - Sanchez-Fuentes, Jose Antonio AU - Sanchez-Fuentes JA AUID- ORCID: 0000-0003-3575-3507 AD - Research Group Movement Sciences and Sport (MS&SPORT), Department of Physical Activity and Sport, Faculty of Sport Sciences, University of Murcia, 30720 Murcia, Spain. LA - eng PT - Journal Article DEP - 20260601 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13296333 OTO - NOTNLM OT - adventure education OT - motivation OT - parkour COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 06:38 MHDA- 2026/06/26 06:39 PMCR- 2026/06/01 CRDT- 2026/06/26 01:05 PHST- 2026/04/06 00:00 [received] PHST- 2026/05/22 00:00 [revised] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/06/26 06:39 [medline] PHST- 2026/06/26 06:38 [pubmed] PHST- 2026/06/26 01:05 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - bs16060874 [pii] AID - behavsci-16-00874 [pii] AID - 10.3390/bs16060874 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Jun 1;16(6):874. doi: 10.3390/bs16060874. PMID- 42351134 OWN - NLM STAT- MEDLINE DCOM- 20260927 LR - 20260930 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Jun 25 TI - Dietary patterns and oral health practices among primary school children aged 6-15 years in urban informal settlements of Eldoret City, Kenya. LID - 10.1186/s12903-026-08778-6 [doi] LID - 1850 AB - BACKGROUND: Dental caries remains one of the most prevalent chronic conditions among school-aged children, disproportionately affecting those in informal settlements where dietary risks and preventive oral health services are limited. AIM: This study assessed dietary patterns, oral hygiene practices, and their association with dental caries among primary school children aged 6-15 years in informal settlements of Eldoret City in Uasin Gishu County, Kenya. METHODS: The study adopted a school-based cross-sectional design and involved 407 primary school children selected using proportionate stratified random sampling. Data was collected using a validated and pretested structured questionnaire, while clinical oral assessment was based on WHO field guidelines for the examination of dental caries. Data was analyzed using SPSS v.26. Chi-square tests assessed associations, and bivariate and multivariate logistic regression models were used to identify independent dietary patterns and oral hygiene practices associated with dental caries. RESULTS: Out of 407 children, 55.3% were females, and their average mean age was 12.15 +/- 2.98 years. The prevalence of dental caries was 26.0% (95% CI: 21.8-30.3). Daily consumption of sugary foods and beverages and suboptimal oral hygiene practices were relatively high. Multivariate logistic regression models revealed daily intake of biscuits, cakes, sweet pies, and buns (AOR = 2.31; 95% CI: 1.36-3.74; p = 0.004), daily consumption of sweets and candy (AOR = 2.42; 95% CI: 1.35-3.91; p = 0.006), brushing less than twice daily (AOR = 2.92; 95% CI: 1.18-3.87; p = 0.023), and not using fluoride toothpaste (AOR = 1.83; 95% CI: 1.12-2.61; p = 0.043) were independently associated with higher odds of dental caries among primary school children. CONCLUSION: Integrated school- and community-based prevention strategies targeting dietary patterns and oral hygiene promotion are urgently needed to reduce preventable oral health inequities among vulnerable schoolchildren. CI - (c) 2026. The Author(s). FAU - Wandia, Florence AU - Wandia F AD - School of Health Sciences, University of Kabianga, Kericho, Kericho County, Kenya. FAU - Wanzala, Joel AU - Wanzala J AD - School of Health Sciences, University of Kabianga, Kericho, Kericho County, Kenya. abbysansiojoel@gmail.com. LA - eng PT - Journal Article DEP - 20260625 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - Child MH - Female MH - Kenya/epidemiology MH - Male MH - Cross-Sectional Studies MH - Adolescent MH - *Dental Caries/epidemiology MH - *Oral Hygiene/statistics & numerical data MH - *Feeding Behavior MH - *Diet/statistics & numerical data MH - Prevalence MH - *Oral Health MH - Toothbrushing/statistics & numerical data MH - Urban Population MH - Fluoride Treatment PMC - PMC13617819 OTO - NOTNLM OT - Dental caries OT - Dietary patterns OT - Informal settlement OT - Kenya OT - Oral health practices OT - School children COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Institutional Scientific Ethics Review Committee (ISERC) of the University of Eastern Africa Baraton (UEAB/ISERC/05/02/2025). The study received a research permit/license for the National Commission for Science, Technology and Innovation (NACOSTI/P/25/4175815). Additionally, permission was sought from the Ministry of Education and selected primary school administration. Informed consent was obtained from the parents or legal guardians of all the participants, as they aged 15 years and below. Researchers explained the aim, benefits, duration, and the activities that the study involved to parents and guardians. Participation was voluntary, and participants were informed that they could withdraw from the study at any time without consequences. Confidentiality and privacy were maintained by using anonymized data and private interviews. Additionally, the study adhered to the principles of the Declaration of Helsinki on ethical research involving human participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/26 00:50 MHDA- 2026/09/28 05:33 PMCR- 2026/06/25 CRDT- 2026/06/25 23:59 PHST- 2026/02/20 00:00 [received] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/09/28 05:33 [medline] PHST- 2026/06/26 00:50 [pubmed] PHST- 2026/06/25 23:59 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.1186/s12903-026-08778-6 [pii] AID - 8778 [pii] AID - 10.1186/s12903-026-08778-6 [doi] PST - epublish SO - BMC Oral Health. 2026 Jun 25;26(1):1850. doi: 10.1186/s12903-026-08778-6. PMID- 42351010 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20260916 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 25 TI - Breaking down breakfast: the relationship between morning meals and learning difficulties in adolescents. LID - 10.1186/s12887-026-07085-x [doi] LID - 856 AB - BACKGROUND: Learning difficulties (LDs) impair academic performance and cognitive function. Dietary factors, particularly the composition of breakfast, may influence LDs. OBJECTIVE: To examine the association between breakfast composition and LDs in adolescents. METHODS: A cross-sectional study was conducted among 501 adolescents aged 10-19 from four schools in Jahrom, Iran. Trained dietitians collected dietary data using three non-consecutive 24-hour recalls (two on weekdays and one on a weekend). Weight and height were measured following a standardized protocol. Additionally, LDs were assessed using the validated Colorado Learning Difficulties Score (CLDS) questionnaire. Higher scores of CLDS reflect greater LDs. RESULTS: Using the CLDS, adolescents were classified into four equal quartiles. In all food group analyses, adolescents who consumed fewer than one serving/day were considered the reference group. Adolescents who consumed more than one serving of dairy had lower odds of being in the highest CLDS quartile (1-2 servings: OR 0.42; 95% CI 0.20-0.87; 3-4 servings: OR 0.19; 95% CI 0.07-0.47; >4 servings: OR 0.22; 95% CI 0.05-0.86). Furthermore, adolescents who consumed more than four servings of simple sugar had higher odds of being in the highest CLDS quartile (> 4 servings: OR 3.60; 95% CI 1.09-11.8). CONCLUSION: Our findings suggest that higher dairy intake and lower consumption of simple sugar waere associated with lower odds of LDs in adolescents. Further longitudinal studies are warranted. CI - (c) 2026. The Author(s). FAU - Rahmanian, Reza AU - Rahmanian R AUID- ORCID: 0009-0004-0125-5096 AD - School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. AD - Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Pirbasti, Ali Razeghi AU - Pirbasti AR AUID- ORCID: 0009-0003-7237-5784 AD - Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Shaygantabar, Mohsen AU - Shaygantabar M AUID- ORCID: 0009-0006-5483-9495 AD - Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Javaheri-Tafti, Fatemeh AU - Javaheri-Tafti F AUID- ORCID: 0009-0002-3299-2684 AD - Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Bahreini-Boroujeni, Leyli Zahra AU - Bahreini-Boroujeni LZ AUID- ORCID: 0009-0006-3898-051X AD - Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Hatami, Alireza AU - Hatami A AUID- ORCID: 0009-0001-8712-0165 AD - Department of Clinical Nutrition School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. AD - Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Khoshrang, Andisheh AU - Khoshrang A AUID- ORCID: 0009-0009-3149-2873 AD - School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Sajedi, Leila AU - Sajedi L AUID- ORCID: 0009-0003-0330-7657 AD - Department of Education, Faculty of Teachers Education, Farhangian University, Shiraz, Iran. FAU - Ajami, Marjan AU - Ajami M AUID- ORCID: 0000-0002-6820-550X AD - Department of Food and Nutrition Policy and Planning Research, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Esmaili, Mina AU - Esmaili M AUID- ORCID: 0000-0002-8422-7864 AD - Department of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Houshiarrad, Anahita AU - Houshiarrad A AD - Department of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. anahrad@yahoo.com. FAU - Doaei, Saeid AU - Doaei S AUID- ORCID: 0000-0002-2532-7478 AD - Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, P.O. Box 19395-4741, Iran. Sdoaei@sbmu.ac.ir. AD - Unit of Nutrition and Cancer, Cancer Epidemiology Research Program Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain. Sdoaei@sbmu.ac.ir. LA - eng PT - Journal Article DEP - 20260625 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Adolescent MH - *Learning Disabilities/etiology/epidemiology MH - Cross-Sectional Studies MH - *Breakfast/psychology MH - Child MH - Female MH - Male MH - Iran MH - *Feeding Behavior PMC - PMC13560118 OTO - NOTNLM OT - Breakfast OT - Cognitive function OT - Diary intake OT - Learning disabilities COIS- Declarations. Ethics approval and consent to participate: The research received approval from the Ethics Committee of the National Nutrition and Food Technology Research Institute at Shahid Beheshti University of Medical Sciences, Iran (IR.SBMU.NNFTRI.REC.1402.052). The study adheres to the principles outlined in the Declaration of Helsinki. All participants provided written informed consent before participating in this study. All personal information about participants will be kept secure in a database. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/26 00:51 MHDA- 2026/09/10 05:36 PMCR- 2026/06/25 CRDT- 2026/06/25 23:55 PHST- 2025/11/26 00:00 [received] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/09/10 05:36 [medline] PHST- 2026/06/26 00:51 [pubmed] PHST- 2026/06/25 23:55 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.1186/s12887-026-07085-x [pii] AID - 7085 [pii] AID - 10.1186/s12887-026-07085-x [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 25;26(1):856. doi: 10.1186/s12887-026-07085-x. PMID- 42351008 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20260916 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 25 TI - Reclassification of SGA and EUGR in very preterm infants after the introduction of Fenton-2025: a retrospective cohort comparison with INTERGROWTH-21st and Fenton-2013. LID - 10.1186/s12887-026-07215-5 [doi] LID - 855 AB - BACKGROUND: In very preterm infants, the classification of small for gestational age (SGA) and extrauterine growth restriction (EUGR) depends on the growth chart used. In this context, the classification implications of the newly introduced Fenton-2025 curves have not yet been evaluated in this population. We compared SGA and EUGR classification across Fenton-2025, INTERGROWTH-21st, and Fenton-2013, and examined chart-specific associations between EUGR and major neonatal morbidities. METHODS: This retrospective single-centre cohort study included 272 infants born at 24-32 weeks' gestation. SGA was defined as birth weight below the 10th percentile. EUGR was defined as discharge weight-for-age Z score below - 2. Associations between chart-defined EUGR and neonatal morbidities were examined using multivariable logistic regression adjusted for gestational age, birth weight, and sex. RESULTS: SGA rates differed in rank order across the three charts, being lowest with Fenton-2013 (9.9%), intermediate with INTERGROWTH-21st (15.8%), and highest with Fenton-2025 (24.3%). For EUGR, the ordering was different: rates were lowest with INTERGROWTH-21st (26.1%), intermediate with Fenton-2013 (33.5%), and highest with Fenton-2025 (40.8%). Despite this difference in rank order, the three charts showed a nested classification pattern. Compared with INTERGROWTH-21st, Fenton-2025 classified 56% more infants (n = 40) as EUGR. Nevertheless, in adjusted analyses, infants classified as EUGR according to the Fenton 2013 and INTERGROWTH-21st charts were associated with higher adjusted odds (aOR 6.37, 95% CI 2.07-19.57, and aOR 5.03, 95% CI 1.82-13.90, respectively) of necrotising enterocolitis (>/= stage II) compared to non-EUGR infants, and this higher adjusted odds persisted after reclassification using the Fenton 2025 chart (aOR 4.96, 95% CI 1.68-14.64). CONCLUSIONS: Fenton-2025 applies a more inclusionary approach in classifying very preterm infants as SGA and EUGR compared with INTERGROWTH-21st and Fenton-2013. The clinical implications of this broader classification require further outcome-linked validation. CI - (c) 2026. The Author(s). FAU - Gur, Kutlay AU - Gur K AUID- ORCID: 0000-0001-6444-8101 AD - Department of Pediatrics, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, University of Health Sciences Turkiye, Istanbul, 34668, Turkiye. kutlaygur@gmail.com. FAU - Topcuoglu, Sevilay AU - Topcuoglu S AUID- ORCID: 0000-0002-1117-196X AD - Division of Neonatology, Department of Pediatrics, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, University of Health Sciences Turkiye, Istanbul, Turkiye. FAU - Dincer, Emre AU - Dincer E AUID- ORCID: 0000-0003-1429-3206 AD - Division of Neonatology, Department of Pediatrics, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, University of Health Sciences Turkiye, Istanbul, Turkiye. FAU - Ozalkaya, Elif AU - Ozalkaya E AUID- ORCID: 0000-0002-0992-1493 AD - Division of Neonatology, Department of Pediatrics, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, University of Health Sciences Turkiye, Istanbul, Turkiye. FAU - Karatekin, Guner AU - Karatekin G AUID- ORCID: 0000-0001-7112-0323 AD - Division of Neonatology, Department of Pediatrics, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, University of Health Sciences Turkiye, Istanbul, Turkiye. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260625 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Retrospective Studies MH - Infant, Newborn MH - *Infant, Small for Gestational Age/growth & development MH - Female MH - Male MH - *Growth Charts MH - *Fetal Growth Retardation/classification/diagnosis MH - *Infant, Premature/growth & development MH - Logistic Models MH - Gestational Age PMC - PMC13560381 OTO - NOTNLM OT - Extrauterine Growth Restriction OT - Fenton Growth Chart OT - Growth Charts OT - INTERGROWTH-21st OT - Infant, Very Premature OT - Small for Gestational Age COIS- Declarations. Ethics approval and consent to participate: Retrospective data collection was approved by the Clinical Research Ethics Committee of Zeynep Kamil Women and Children's Diseases Training and Research Hospital (Decision No. 93, Date: 21 April 2021). The updated Fenton-2025 reanalysis for the current manuscript was approved by the Zeynep Kamil Hospital Non-Interventional Research Ethics Committee (Decision No. 26, Date: 25 February 2026). The study was conducted in accordance with the Declaration of Helsinki. Owing to the retrospective nature of the updated reanalysis and the use of previously recorded hospital data, separate informed consent to participate was not required, as stated in the ethics application approved by the Zeynep Kamil Hospital Non-Interventional Research Ethics Committee. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/26 00:50 MHDA- 2026/09/10 05:36 PMCR- 2026/06/25 CRDT- 2026/06/25 23:55 PHST- 2026/04/22 00:00 [received] PHST- 2026/06/18 00:00 [accepted] PHST- 2026/09/10 05:36 [medline] PHST- 2026/06/26 00:50 [pubmed] PHST- 2026/06/25 23:55 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.1186/s12887-026-07215-5 [pii] AID - 7215 [pii] AID - 10.1186/s12887-026-07215-5 [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 25;26(1):855. doi: 10.1186/s12887-026-07215-5. PMID- 42350907 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260625 IS - 1742-7843 (Electronic) IS - 1742-7835 (Linking) VI - 139 IP - 2 DP - 2026 Aug TI - Association Between Urinary Heavy Metals and Developmental Disorders in Children Aged 6-15 Years: A Study Based on the NHANES Database. PG - e70266 LID - 10.1111/bcpt.70266 [doi] AB - This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2018, enrolling a total of 4525 children and adolescents aged 6-15 years. Weighted logistic regression, weighted quantile sum (WQS) regression and quantile g-computation (qgcomp) models were applied to explore the associations between nine urinary heavy metals (UHMs) and developmental disorders (DDs). After full covariate adjustment, urinary lead (Pb) (OR = 1.30, 95% CI: 1.10-1.54) and urinary antimony (Sb) (OR = 1.41, 95% CI: 1.18-1.69) were found to be positively correlated with DDs. Combined exposure models further identified a positive joint relationship between the mixture of UHMs and DDs, with Pb and Sb serving as the major contributing components. Sensitivity analyses that defined DDs solely based on receipt of special education or early intervention services yielded consistent findings. Given the limitations inherent to the cross-sectional design, single-spot urine sampling and heterogeneous outcome definitions, the present findings can only demonstrate correlational relationships, and further longitudinal investigations are required for conclusive validation. CI - (c) 2026 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). Published by John Wiley & Sons Ltd. FAU - Liao, Yanping AU - Liao Y AD - Department of Pediatrics, Longyan First Hospital of Fujian Medical University, Longyan, Fujian, China. FAU - Zhan, Lingling AU - Zhan L AD - Department of Pediatrics, Longyan First Hospital of Fujian Medical University, Longyan, Fujian, China. FAU - Li, Hong AU - Li H AUID- ORCID: 0009-0004-1125-7079 AD - Department of Pediatrics, Longyan First Hospital of Fujian Medical University, Longyan, Fujian, China. LA - eng PT - Journal Article PL - England TA - Basic Clin Pharmacol Toxicol JT - Basic & clinical pharmacology & toxicology JID - 101208422 RN - 0 (Metals, Heavy) RN - 2P299V784P (Lead) RN - 0 (Environmental Pollutants) SB - IM MH - Humans MH - Child MH - Cross-Sectional Studies MH - *Metals, Heavy/urine MH - Adolescent MH - Nutrition Surveys MH - Female MH - Male MH - *Developmental Disabilities/urine/epidemiology MH - United States/epidemiology MH - *Environmental Exposure/adverse effects/analysis MH - Lead/urine MH - Databases, Factual MH - *Environmental Pollutants/urine OAB - Exposure to heavy metals may raise the risk of developmental disorders (DDs) in children. This study analysed urine samples from over 4500 US children aged 6-15 for nine metals. Higher levels of lead and antimony were linked to greater odds of having a DD. When considering all metals together, lead and antimony were the main drivers of increased risk. The link with lead was stronger in boys, while antimony affected both boys and girls. Reducing exposure to these metals could help prevent DDs, especially in vulnerable groups like boys. OABL- eng OTO - NOTNLM OT - NHANES OT - children OT - developmental disorders OT - urinary heavy metals EDAT- 2026/06/26 00:47 MHDA- 2026/06/27 04:10 CRDT- 2026/06/25 23:34 PHST- 2026/06/10 00:00 [revised] PHST- 2026/03/20 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/06/27 04:10 [medline] PHST- 2026/06/26 00:47 [pubmed] PHST- 2026/06/25 23:34 [entrez] AID - 10.1111/bcpt.70266 [doi] PST - ppublish SO - Basic Clin Pharmacol Toxicol. 2026 Aug;139(2):e70266. doi: 10.1111/bcpt.70266. PMID- 42349796 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260807 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 226 DP - 2026 Nov 1 TI - Why we eat: Development and validation of a 7-factor Motivations for Eating Profile (MEP-7). PG - 108699 LID - S0195-6663(26)00261-8 [pii] LID - 10.1016/j.appet.2026.108699 [doi] AB - Understanding why people eat is crucial for the prevention and management of overeating and obesity, but existing psychometric tools typically assess a narrow set of motivational constructs. The current study developed a comprehensive, theory-driven questionnaire from a recently validated framework of eating behaviour traits derived from 18 existing eating behaviour scales and evaluated its psychometric properties and external validity. Study 1 used a structured review panel of n = 30 adults and applied item response theory to a survey of n = 1279 adults, to select items from widely used eating behaviour scales and novel items for 'pleasure' and 'health'. Study 2 surveyed a UK-representative adult sample (1042 females, 968 males) to perform exploratory (n = 1005) and confirmatory (n = 1005) factor analyses. Internal consistency, measurement invariance, and associations between latent motives and body mass index (BMI), self-reported weight change, lifetime weight loss attempts, eating rate and physical activity were examined. Exploratory and confirmatory factor analyses revealed a seven-factor, 28-item model (reactive eating, restricted eating, negative emotional eating, positive emotional eating, homeostatic eating, eating for pleasure and eating for health) with good model fit (CFI = 0.993, SRMR = 0.045, RMSEA = 0.046) and good to excellent reliability (omegaT = 0.77-0.93). Scalar invariance by sex, age, and education was supported. Latent motives showed theoretically consistent associations with external outcomes: higher reactive and negative emotional eating related to higher BMI and faster eating rate; homeostatic and health motives related to lower BMI and higher physical activity. The 7-Factor Motivation for Eating Profile (MEP-7) provides a brief, psychometrically robust profile of seven eating behaviour motivations with evidence of predictive validity. The MEP-7 supports research and clinical phenotyping and may inform behaviour change strategies for weight management. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Dakin, Clarissa AU - Dakin C AD - School of Food Science and Nutrition, University of Leeds, Leeds, LS2 9JT, UK. Electronic address: psccda@leeds.ac. FAU - Finlayson, Graham AU - Finlayson G AD - Appetite Control and Energy Balance Research Group (ACEB), School of Psychology, Faculty of Medicine and Health, University of Leeds, Leeds, UK. FAU - James Stubbs, R AU - James Stubbs R AD - Appetite Control and Energy Balance Research Group (ACEB), School of Psychology, Faculty of Medicine and Health, University of Leeds, Leeds, UK. LA - eng PT - Journal Article PT - Validation Study DEP - 20260625 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - *Motivation MH - Male MH - *Feeding Behavior/psychology MH - Adult MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Psychometrics MH - Body Mass Index MH - Emotional Eating MH - Factor Analysis, Statistical MH - Middle Aged MH - Young Adult MH - United Kingdom MH - *Eating/psychology MH - Obesity/psychology MH - Exercise/psychology MH - Adolescent MH - Pleasure OTO - NOTNLM OT - Eating behaviour traits OT - Factor analysis OT - Item response theory OT - Motivations for eating OT - Psychometrics OT - Weight management COIS- Declaration of competing interest Pr. James Stubbs and Dr Clarissa Dakin declare that they consult for Slimming World UK through the University of Leeds. Slimming World were not involved in the analysis or interpretation of this articles. No other authors declare a conflict of interest. EDAT- 2026/06/26 00:47 MHDA- 2026/08/08 00:40 CRDT- 2026/06/25 19:32 PHST- 2026/03/06 00:00 [received] PHST- 2026/06/10 00:00 [revised] PHST- 2026/06/25 00:00 [accepted] PHST- 2026/08/08 00:40 [medline] PHST- 2026/06/26 00:47 [pubmed] PHST- 2026/06/25 19:32 [entrez] AID - S0195-6663(26)00261-8 [pii] AID - 10.1016/j.appet.2026.108699 [doi] PST - ppublish SO - Appetite. 2026 Nov 1;226:108699. doi: 10.1016/j.appet.2026.108699. Epub 2026 Jun 25. PMID- 42348754 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20261006 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Jul 13 TI - An AI-Assisted Tool to Predict Continuous Glucose Monitor Adherence in Children With Type 1 Diabetes in Oman: Protocol for a Multiphase Mixed Methods Translational Study. PG - e99626 LID - 10.2196/99626 [doi] LID - e99626 AB - BACKGROUND: Type 1 diabetes mellitus (T1DM) in children requires sustained self-management to achieve glycemic targets. Continuous glucose monitoring (CGM) has transformed pediatric diabetes care; yet, adherence to device wear remains inconsistent. In May 2024, Oman launched a national initiative distributing CGMs to children with T1DM across all governorates, creating a real-world opportunity to study adherence determinants and to develop a locally validated AI-assisted predictive tool. OBJECTIVE: This multiphase translational research project aims to (1) characterize the population of Omani children with T1DM; (2) identify demographic, psychosocial, dietary, and physical activity correlates of optimal CGM use; (3) develop, train, and validate an AI-assisted behavioral predictive tool "OMNIdiasense" to forecast CGM adherence prior to device dispensing; and (4) pilot test the OMNIdiasense tool. METHODS: Three sequential, interlinked substudies will be conducted. Substudy 1 is a retrospective cohort analysis of routinely collected Al Shifa data for all children who received CGMs between July 2024 and February 2025, with glycemic, anthropometric, and laboratory outcomes compared at baseline and at >/=3 months. Outputs on adherence prevalence, and clinical predictors become the structured input layer for the proposed AI model. Substudy 2 is a cross-sectional, mixed methods study using face-to-face structured interviews with a randomly selected sample of children aged 10-18 years, classified as "CGM optimizers" (>/=6 days/week) or "CGM subusers" (<6 days/week or discontinued); responses across validated behavioral, stress, and dietary instruments are compared. Outputs are the psychosocial and behavioral feature set, qualitative themes, and effect sizes that drive feature selection for the AI model. Substudy 3 develops the AI tool (OMNIdiasense), comprising (1) a quasi-experimental single-arm pilot among 100 existing CGM subusers and (2) a parallel pilot randomized controlled trial (n=50; 25 intervention, 25 control) among newly diagnosed children, with assessments at baseline, 3, 6, and 12 months. The primary outcome is between-group difference in CGM adherence; secondary outcomes include hemoglobin A(1c), anthropometric, cardiovascular, and laboratory measures, and barriers to use. Reporting will follow SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) 2025 (interventional component), STROBE (Strengthening the Reporting of Observational Studies in Epidemiology; observational component), the CONSORT (Consolidated Standards of Reporting Trials) 2025 extension for pilot and feasibility trials, COREQ (Consolidated Criteria for Reporting Qualitative Research; qualitative component), and TRIPOD+AI (Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis + Artificial Intelligence; predictive model). RESULTS: The proposed AI tool is intended as a decision-support adjunct and not a gatekeeping mechanism for CGM access. CONCLUSIONS: To our knowledge, OMNIdiasense is the first AI tool in the Gulf Cooperation Council region to predict pediatric CGM adherence. By targeting behaviorally vulnerable patients before sensor distribution, OMNIdiasense is expected to support clinical benefit and reduce financial waste. TRIAL REGISTRATION: ISRCTN Registry ISRCTN15827616; https://doi.org/10.1186/ISRCTN15827616. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/99626. CI - (c)Thamra Al Ghafri, Saud Al Harthi, Asma Bait Ishaq, Huwaida Al Harthi, Maryam Al Muaini, Rahma Al-Ghadani, Ahmed Aljufaili, Mohamed Al Harb, Abdullah Al Saadi, Abdelhamid Abdessalem, Noushath Shaffi, Mohamed Ahmed, Said Jaboob, Nadia Al Maqbali, Moza Al-Shehhi, Talib Al Kalbani, Amal Al Shukaili, Jannat Al Harthi. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 13.07.2026. FAU - Al Ghafri, Thamra AU - Al Ghafri T AUID- ORCID: 0000-0002-4818-9565 AD - Directorate General of Health Services, Muscat, Oman. AD - Sultan Qaboos University, Muscat, Muscat, Oman. FAU - Al Harthi, Saud AU - Al Harthi S AUID- ORCID: 0000-0002-5457-4662 AD - Ministry of Health, Directorate General of Khaula Hospital, Muscat, Oman. FAU - Bait Ishaq, Asma AU - Bait Ishaq A AUID- ORCID: 0009-0009-7263-2692 AD - Directorate General of Health Services, Muscat, Oman. FAU - Al Harthi, Huwaida AU - Al Harthi H AUID- ORCID: 0009-0004-1540-5796 AD - Directorate General of Health Services, Muscat, Oman. FAU - Al Muaini, Maryam AU - Al Muaini M AUID- ORCID: 0009-0002-4555-427X AD - Ministry of Health, Ministry of Health, Batina, Oman. FAU - Al-Ghadani, Rahma AU - Al-Ghadani R AUID- ORCID: 0009-0008-1130-7987 AD - Ministry of Health, Ministry of Health, Batina, Oman. FAU - Aljufaili, Ahmed AU - Aljufaili A AUID- ORCID: 0009-0004-0480-3422 AD - Ministry of Health, Ministry of Health, Sharqiyah, Oman. FAU - Al Harb, Mohamed AU - Al Harb M AUID- ORCID: 0009-0007-7035-2350 AD - Ministry of Health, Ministry of Health, Sharqiyah, Oman. FAU - Al Saadi, Abdullah AU - Al Saadi A AUID- ORCID: 0009-0007-8798-0353 AD - Ministry of Health, Ministry of Health, Sharqiyah, Oman. FAU - Abdessalem, Abdelhamid AU - Abdessalem A AUID- ORCID: 0000-0003-2950-2875 AD - Sultan Qaboos University, Muscat, Muscat, Oman. FAU - Shaffi, Noushath AU - Shaffi N AUID- ORCID: 0000-0001-9243-8402 AD - Sultan Qaboos University, Muscat, Muscat, Oman. FAU - Ahmed, Mohamed AU - Ahmed M AUID- ORCID: 0009-0000-9458-9087 AD - Ministry of Health, Ministry of Health, AlWosta, Oman. FAU - Jaboob, Said AU - Jaboob S AUID- ORCID: 0009-0009-6411-7244 AD - Ministry of Health, Ministry of Health, Dhofar, Oman. FAU - Al Maqbali, Nadia AU - Al Maqbali N AUID- ORCID: 0000-0002-9926-6452 AD - Ministry of Health, Ministry of Health, Aldhahira, Oman. FAU - Al-Shehhi, Moza AU - Al-Shehhi M AUID- ORCID: 0000-0002-1001-2043 AD - Ministry of Health, Ministry of Health, Musandam, Oman. FAU - Al Kalbani, Talib AU - Al Kalbani T AUID- ORCID: 0000-0003-4585-0992 AD - Ministry of Health, Ministry of Health, Buraimi, Oman. FAU - Al Shukaili, Amal AU - Al Shukaili A AUID- ORCID: 0009-0002-6884-6689 AD - Ministry of Health, Ministry of Health, Aldakhilyah, Oman. FAU - Al Harthi, Jannat AU - Al Harthi J AUID- ORCID: 0009-0007-4182-5462 AD - National University of Science and Technology, Sohar, Oman. LA - eng SI - ISRCTN/ISRCTN15827616 PT - Clinical Trial Protocol PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260713 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 RN - 0 (Blood Glucose) SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Artificial Intelligence MH - Blood Glucose/analysis MH - *Blood Glucose Self-Monitoring MH - *Continuous Glucose Monitoring/methods MH - *Diabetes Mellitus, Type 1/blood/psychology MH - Oman MH - *Patient Compliance/statistics & numerical data MH - Retrospective Studies MH - Observational Studies as Topic PMC - PMC13408470 OTO - NOTNLM OT - adherence OT - adolescent OT - artificial intelligence OT - behavioral prediction OT - continuous glucose monitoring OT - machine learning OT - pediatric OT - type 1 diabetes. COIS- Conflicts of Interest: None declared. EDAT- 2026/06/26 04:10 MHDA- 2026/07/14 12:34 PMCR- 2026/07/13 CRDT- 2026/06/25 14:53 PHST- 2026/04/28 00:00 [received] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/06/21 00:00 [revised] PHST- 2026/07/14 12:34 [medline] PHST- 2026/06/26 04:10 [pubmed] PHST- 2026/06/25 14:53 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - v15i1e99626 [pii] AID - 10.2196/99626 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Jul 13;15:e99626. doi: 10.2196/99626. PMID- 42346395 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260625 LR - 20260813 IS - 2218-1989 (Print) IS - 2218-1989 (Electronic) IS - 2218-1989 (Linking) VI - 16 IP - 6 DP - 2026 Jun 14 TI - Discriminative Ability of TyG, TyG-WC, BAI, FGIR, and QUICKI Indexes in Identifying Metabolic Syndrome in a Pediatric Population with Obesity. LID - 10.3390/metabo16060415 [doi] LID - 415 AB - Background/Objectives: Pediatric obesity is closely associated with metabolic syndrome (MetS), a condition linked to increased cardiometabolic risk. Early identification of high-risk individuals remains challenging. This study aimed to evaluate the diagnostic performance of selected anthropometric, metabolic dysfunction and insulin resistance indexes for identifying MetS in children and adolescents with obesity. Methods: In this retrospective, cross-sectional, single-center study, 758 children and adolescents with obesity (mean age 14.8 +/- 2.1 years; 59.9% females) hospitalized for a body weight-reduction program were included. MetS was defined according to International Diabetes Federation criteria, in which central obesity is a mandatory diagnostic component. The triglyceride-glucose (TyG), TyG-waist circumference (TyG-WC), body adiposity index (BAI), fasting glucose-to-insulin ratio (FGIR), and quantitative insulin sensitivity check index (QUICKI) were calculated. Receiver operating characteristic curve analysis was used to assess their discriminative ability. Results: The prevalence of MetS was 27.8% and was significantly higher in males than females (34.9% vs. 23.1%, p < 0.0001). TyG and TyG-WC showed the best discriminative performance (AUC 0.75 and 0.76, respectively), although with only moderate sensitivity and specificity. FGIR and QUICKI demonstrated lower accuracy (AUC 0.64 and 0.63), whereas BAI showed no discriminative ability (AUC 0.48). These findings were consistent across sexes, although sex-specific differences in both MetS prevalence and optimal cut-off values were observed. Correlation analyses confirmed moderate associations between TyG-based indexes and MetS, whereas other indexes showed weaker relationships. Conclusions: In the present cohort of children and adolescents with obesity, TyG and TyG-WC showed the best performance in identifying MetS compared with the other evaluated indexes. However, their performance remained moderate, and the proposed cut-off values require validation in independent populations. These indexes may represent simple supportive screening and risk-stratification tools but should be used alongside comprehensive clinical assessment and established diagnostic criteria rather than as stand-alone diagnostic measures. FAU - Tamini, Sofia AU - Tamini S AUID- ORCID: 0000-0002-2503-5117 AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, IRCCS, Piancavallo, 28824 Verbania, Italy. FAU - Bondesan, Adele AU - Bondesan A AUID- ORCID: 0000-0002-9145-5400 AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, IRCCS, Piancavallo, 28824 Verbania, Italy. FAU - Caroli, Diana AU - Caroli D AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, IRCCS, Piancavallo, 28824 Verbania, Italy. FAU - Frigerio, Francesca AU - Frigerio F AUID- ORCID: 0009-0007-1227-1747 AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, IRCCS, Piancavallo, 28824 Verbania, Italy. FAU - Sartorio, Alessandro AU - Sartorio A AUID- ORCID: 0000-0002-9620-4133 AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, IRCCS, Piancavallo, 28824 Verbania, Italy. LA - eng GR - ricerca corrente/Ministry of Health/ PT - Journal Article DEP - 20260614 PL - Switzerland TA - Metabolites JT - Metabolites JID - 101578790 PMC - PMC13303531 OTO - NOTNLM OT - FGIR OT - MetS OT - QUICKI OT - TyG OT - TyG-WC OT - adolescents OT - children OT - metabolic syndrome OT - obesity OT - pediatric obesity COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/25 19:09 MHDA- 2026/06/25 19:10 PMCR- 2026/06/14 CRDT- 2026/06/25 09:43 PHST- 2026/05/06 00:00 [received] PHST- 2026/06/10 00:00 [revised] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/06/25 19:10 [medline] PHST- 2026/06/25 19:09 [pubmed] PHST- 2026/06/25 09:43 [entrez] PHST- 2026/06/14 00:00 [pmc-release] AID - metabo16060415 [pii] AID - metabolites-16-00415 [pii] AID - 10.3390/metabo16060415 [doi] PST - epublish SO - Metabolites. 2026 Jun 14;16(6):415. doi: 10.3390/metabo16060415. PMID- 42345641 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260813 IS - 2543-6031 (Electronic) IS - 2451-4934 (Print) IS - 2451-4934 (Linking) VI - 94 IP - 3 DP - 2026 Jun 5 TI - Impact of Highly Effective CFTR Modulator Therapy on Physical Activity, Sleep, and Sinonasal Symptoms in Preschool Children with Cystic Fibrosis: A Prospective Single-Center Pilot Study. LID - 10.3390/arm94030036 [doi] LID - 36 AB - Background: Highly effective CFTR modulation with Elexacaftor/Tezacaftor/Ivacaftor (ETI) markedly improves clinical outcomes in people with cystic fibrosis (CF). Data on its effects on physical activity, sleep, sinonasal symptoms, and parent-perceived outcomes in preschool-aged children are limited. Methods: In this prospective, observational, single-center cohort study, ten children with cystic fibrosis (aged 2-6 years) and at least one CFTR variant eligible for ETI were included. Data were collected using wrist-worn Garmin vivofit Junior 2 activity trackers and standardized questionnaires one month before ETI initiation and at 1, 3, 6, and 12 months after start of ETI. Outcomes included step count, minutes of moderate-to-vigorous physical activity, sleep parameters, sinonasal symptoms, and parental perceptions. Results: ETI was well tolerated. Sweat chloride levels decreased significantly. Physical activity improved at 3 and 6 months (step count and active minutes/day; p < 0.05) but declined to near-baseline levels at 12 months. Parental assessments of physical and sporting performance showed sustained improvement. Sleep duration remained stable, with no changes in deep or light sleep phases or nighttime awakenings. Sinonasal symptoms remained low. Discussion & Conclusions: Preliminary findings of this exploratory pilot study show that improvement in physical activity after three and six months of ETI therapy might be attributable to seasonality, as therapy was started in winter months. No changes in sleep duration or sleep patterns are reassuring in this small cohort of young children with CF. ETI therapy was safe and well tolerated. Parental appraisal of their children's physical performance improved after start of ETI. Longitudinal, controlled studies involving larger cohorts are required to validate these findings and to account for potential confounding factors, such as age-dependent changes and individual and environmental factors such as seasonal variation. FAU - Schellhorn, Stella AU - Schellhorn S AD - Department of Pediatrics and Adolescent Medicin, Ulm University Medical Center, Ulm University, Eythstrasse 24, 89075 Ulm, Germany. FAU - Schmidt, Hanna AU - Schmidt H AD - Department of Pediatrics and Adolescent Medicin, Ulm University Medical Center, Ulm University, Eythstrasse 24, 89075 Ulm, Germany. FAU - Janda, Ales AU - Janda A AD - Department of Pediatrics and Adolescent Medicin, Ulm University Medical Center, Ulm University, Eythstrasse 24, 89075 Ulm, Germany. FAU - Gulke, Doris AU - Gulke D AD - Department of Pediatrics and Adolescent Medicin, Ulm University Medical Center, Ulm University, Eythstrasse 24, 89075 Ulm, Germany. FAU - Toth, Monika AU - Toth M AD - Department of Pediatrics and Adolescent Medicin, Ulm University Medical Center, Ulm University, Eythstrasse 24, 89075 Ulm, Germany. FAU - Fabricius, Dorit AU - Fabricius D AUID- ORCID: 0000-0002-2019-8101 AD - Department of Pediatrics and Adolescent Medicin, Ulm University Medical Center, Ulm University, Eythstrasse 24, 89075 Ulm, Germany. FAU - Bode, Sebastian F N AU - Bode SFN AUID- ORCID: 0000-0001-7217-3312 AD - Department of Pediatrics and Adolescent Medicin, Ulm University Medical Center, Ulm University, Eythstrasse 24, 89075 Ulm, Germany. LA - eng PT - Journal Article PT - Observational Study DEP - 20260605 PL - Switzerland TA - Adv Respir Med JT - Advances in respiratory medicine JID - 101697329 RN - 0 (Aminophenols) RN - 0 (Quinolones) RN - 126880-72-6 (Cystic Fibrosis Transmembrane Conductance Regulator) RN - 0 (Pyrazoles) RN - 0 (Benzodioxoles) RN - 0 (Indoles) RN - 0 (Pyridines) RN - RRN67GMB0V (elexacaftor) RN - 8RW88Y506K (tezacaftor) RN - 0 (Drug Combinations) RN - 1Y740ILL1Z (ivacaftor) RN - 0 (Thiophenes) RN - 0 (Pyrrolidines) SB - IM MH - Humans MH - Pilot Projects MH - Prospective Studies MH - Child, Preschool MH - Female MH - Male MH - *Cystic Fibrosis/drug therapy/complications/physiopathology MH - Child MH - *Exercise MH - *Aminophenols/therapeutic use MH - *Quinolones/therapeutic use MH - *Cystic Fibrosis Transmembrane Conductance Regulator/genetics MH - *Pyrazoles/therapeutic use MH - *Benzodioxoles/therapeutic use MH - *Indoles/therapeutic use MH - *Pyridines/therapeutic use MH - *Sleep/drug effects MH - Drug Combinations MH - Thiophenes/therapeutic use MH - Pyrrolidines PMC - PMC13296162 OTO - NOTNLM OT - CFTR-modulator OT - actigraphy OT - activity OT - cystic fibrosis OT - preschool children OT - sinonasal symptoms OT - sleep OT - wearables COIS- The authors declare no conflict of interest. EDAT- 2026/06/25 12:38 MHDA- 2026/06/25 12:39 PMCR- 2026/06/05 CRDT- 2026/06/25 09:33 PHST- 2026/04/28 00:00 [received] PHST- 2026/06/01 00:00 [revised] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/06/25 12:39 [medline] PHST- 2026/06/25 12:38 [pubmed] PHST- 2026/06/25 09:33 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - arm94030036 [pii] AID - arm-94-00036 [pii] AID - 10.3390/arm94030036 [doi] PST - epublish SO - Adv Respir Med. 2026 Jun 5;94(3):36. doi: 10.3390/arm94030036. PMID- 42344529 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260625 LR - 20260813 IS - 1178-2390 (Print) IS - 1178-2390 (Electronic) IS - 1178-2390 (Linking) VI - 19 DP - 2026 TI - Family Empowerment for Stunting Prevention in Children Aged 0-2 Years: A Concept Analysis. PG - 616138 LID - 10.2147/JMDH.S616138 [doi] LID - 616138 AB - BACKGROUND: Stunting in children aged 0-2 years remains a major global health challenge, particularly in low‑ and middle‑income countries, with long‑term consequences for growth and development. Although family empowerment is widely promoted as a strategy for stunting prevention, its conceptualization within stimulation, early detection, and family‑centered care remains fragmented. METHODS: Guided by Walker and Avant's concept analysis framework, this study systematically examined literature retrieved from PubMed, Scopus, and Google Scholar (July 2025). Studies were screened for relevance to family empowerment, caregiving, health literacy, and growth monitoring in the context of children aged 0-2 years. RESULTS: Twenty‑seven eligible studies were synthesized to refine the construct of family empowerment in stunting prevention. Across the reviewed literature, family empowerment was consistently conceptualized as a multidimensional process characterized by five interrelated attributes-reflective decision‑making, self‑efficacy, participation, health literacy integration, and resource mobilization-positioning families as active agents in growth monitoring, stimulation, and timely intervention during the first 1000 days of life. CONCLUSION: This analysis reframes family empowerment as a strategic, family‑centered pathway for stunting prevention. By advancing conceptual clarity within nursing and culturally diverse caregiving contexts, the findings inform practice and policy through the integration of empowerment indicators alongside growth monitoring and highlight priorities for future research focused on culturally responsive validation of empowerment measures. CI - (c) 2026 Sutini et al. FAU - Sutini, Titin AU - Sutini T AUID- ORCID: 0000-0003-1077-0992 AD - Faculty of Nursing, Universitas Padjadjaran, Bandung, Indonesia. AD - Faculty of Nursing, Universitas Muhammadiyah Jakarta, Jakarta, Indonesia. FAU - Rakhmawati, Windy AU - Rakhmawati W AUID- ORCID: 0000-0001-7173-4886 AD - Faculty of Nursing, Universitas Padjadjaran, Bandung, Indonesia. FAU - Mediani, Henny Suzana AU - Mediani HS AUID- ORCID: 0000-0001-6960-3692 AD - Faculty of Nursing, Universitas Padjadjaran, Bandung, Indonesia. FAU - Permatasari, Tria Astika Endah AU - Permatasari TAE AUID- ORCID: 0000-0001-9589-3814 AD - Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta, Jakarta, Indonesia. LA - eng PT - Journal Article PT - Review DEP - 20260618 PL - New Zealand TA - J Multidiscip Healthc JT - Journal of multidisciplinary healthcare JID - 101512691 PMC - PMC13290388 OTO - NOTNLM OT - child nutrition OT - concept analysis OT - early childhood OT - family empowerment OT - family-centre care OT - stunting prevention COIS- The authors declare no conflicts of interest in this work. EDAT- 2026/06/25 06:37 MHDA- 2026/06/25 06:38 PMCR- 2026/06/18 CRDT- 2026/06/25 04:40 PHST- 2026/04/11 00:00 [received] PHST- 2026/06/06 00:00 [accepted] PHST- 2026/06/25 06:38 [medline] PHST- 2026/06/25 06:37 [pubmed] PHST- 2026/06/25 04:40 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 616138 [pii] AID - 10.2147/JMDH.S616138 [doi] PST - epublish SO - J Multidiscip Healthc. 2026 Jun 18;19:616138. doi: 10.2147/JMDH.S616138. eCollection 2026. PMID- 42344477 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260625 LR - 20260813 IS - 2691-3593 (Electronic) IS - 2691-3593 (Linking) VI - 7 IP - 2 DP - 2026 Jun TI - Patient-Reported Outcomes and Body Mass Index in Adolescents and Young Adults After Gender-Affirming Chest Surgery: A Single-Center Cross-Sectional Study. PG - e679 LID - 10.1097/AS9.0000000000000679 [doi] AB - OBJECTIVE: To assess the impact of body mass index (BMI) on patient-reported outcomes after gender-affirming chest surgery in adolescents. BACKGROUND: Despite most previous studies finding no association between BMI and patient-reported outcomes in adults undergoing gender-affirming chest surgery, BMI eligibility requirements remain widely used. Moreover, little data exists regarding the impact of BMI on these outcomes in adolescents. METHODS: A cross-sectional, patient-reported outcome survey study was conducted at a pediatric hospital from April to July 2024. Eligible individuals were at least 1-year postoperative from gender-affirming chest surgery. The primary outcome was the effect of BMI on scores from 7 validated patient-reported outcome measures, including BODY-Q Chest and Nipple, Gender Congruence and Life Satisfaction, Satisfaction with Decision, and Decision Regret Scale, compared between adolescent and young adult cohorts. RESULTS: Among 77 participants who completed the survey, 42 (54.5%) underwent surgery as adolescents and 35 (45.5%) as young adults. Patient-reported outcomes evaluating appearance satisfaction, psychosocial well-being, and decisional satisfaction were high, whereas decisional regret was low. Scores did not significantly differ between adolescent and young adult cohorts, and most patient-reported outcome measures were not significantly influenced by BMI. CONCLUSION: After gender-affirming chest surgery, both adolescents and young adults reported high appearance satisfaction, psychosocial well-being, and decisional satisfaction, along with low decisional regret. For the majority of patient-reported outcomes, these positive results were not associated with BMI, suggesting that gender-affirming chest surgery is associated with high quality of life for adolescents and young adults regardless of BMI. CI - Copyright (c) 2026 The Author(s). Published by Wolters Kluwer Health, Inc. FAU - Haley, Caleb AU - Haley C AD - From the Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI. AD - National Clinician Scholars Program, Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI. FAU - Younoszai, Maya AU - Younoszai M AD - Division of Plastic Surgery, Seattle Children's Hospital, Seattle, WA. FAU - Roblee, Cole V AU - Roblee CV AD - Department of Surgery, Swedish Medical Center, Seattle, WA. FAU - Haugen, Peter AU - Haugen P AD - Division of Plastic Surgery, Seattle Children's Hospital, Seattle, WA. FAU - Araya-Colvin, Justine AU - Araya-Colvin J AD - Division of Plastic Surgery, Seattle Children's Hospital, Seattle, WA. FAU - Brydges, Hilliard T AU - Brydges HT AD - Division of Plastic Surgery, Department of Surgery, University of Washington Medical Center, Seattle, WA. FAU - Nguyen, Alisha AU - Nguyen A AD - Elson S. Floyd College of Medicine, Washington State University, Spokane, WA. FAU - Tople, Tannon AU - Tople T AD - University of Minnesota Twin Cities School of Medicine, Minneapolis, MN. FAU - Faino, Anna V AU - Faino AV AD - Core for Biostatistics, Epidemiology and Analytics in Research, Seattle Children's Research Institute, Seattle Children's Hospital, Seattle, WA. FAU - Gopalan, Maya AU - Gopalan M AD - Division of Plastic Surgery, Seattle Children's Hospital, Seattle, WA. FAU - Eble, Danielle AU - Eble D AD - Division of Plastic Surgery, Department of Surgery, Oregon Health & Science University, Portland, OR. FAU - Ettinger, Russell E AU - Ettinger RE AD - Division of Plastic Surgery, Seattle Children's Hospital, Seattle, WA. AD - Division of Plastic Surgery, Department of Surgery, University of Washington Medical Center, Seattle, WA. FAU - Morrison, Shane D AU - Morrison SD AD - Division of Plastic Surgery, Seattle Children's Hospital, Seattle, WA. AD - Division of Plastic Surgery, Department of Surgery, University of Washington Medical Center, Seattle, WA. AD - Department of Urology, University of Washington Medical Center, Seattle, WA. LA - eng PT - Journal Article DEP - 20260527 PL - United States TA - Ann Surg Open JT - Annals of surgery open : perspectives of surgical history, education, and clinical approaches JID - 101769928 PMC - PMC13290217 OTO - NOTNLM OT - adolescents OT - body mass index OT - gender-affirming surgery OT - obesity OT - patient-reported outcomes COIS- Disclosure: The authors declare that they have nothing to disclose. EDAT- 2026/06/25 06:36 MHDA- 2026/06/25 06:37 PMCR- 2026/05/27 CRDT- 2026/06/25 04:39 PHST- 2026/01/23 00:00 [received] PHST- 2026/04/25 00:00 [accepted] PHST- 2026/06/25 06:37 [medline] PHST- 2026/06/25 06:36 [pubmed] PHST- 2026/06/25 04:39 [entrez] PHST- 2026/05/27 00:00 [pmc-release] AID - AOSO-D-26-00020 [pii] AID - 10.1097/AS9.0000000000000679 [doi] PST - epublish SO - Ann Surg Open. 2026 May 27;7(2):e679. doi: 10.1097/AS9.0000000000000679. eCollection 2026 Jun. PMID- 42343262 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20260916 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 24 TI - Agreement between random upper arm circumference and standard mid-upper arm circumference for identifying acute malnutrition among children aged 6-59 months in Southwest Ethiopia. LID - 10.1186/s12887-026-07125-6 [doi] LID - 851 AB - BACKGROUND: Mid-Upper Arm Circumference (MUAC) is a widely used, rapid, and low-cost anthropometric tool for community-based screening of acute malnutrition among children. However, accurate MUAC assessment requires identification of the midpoint of the upper arm and proper tape placement, which may contribute to inter-observer variability and inconsistencies in field measurements. Random Upper Arm Circumference (RUAC) has been proposed as a simpler alternative for community screening. Nevertheless, evidence regarding the agreement and validity of RUAC compared with standard MUAC for identifying wasting among Ethiopian children remains limited. Therefore, this study aimed to assess the concordance and validity of RUAC compared with MUAC in identifying wasting among children aged 6-59 months in Southwest Ethiopia. METHODS: A community-based cross-sectional study was conducted among 591 children aged 6-59 months in Southwest Ethiopia from June 2 to June 30, 2023. Participants were selected using simple random sampling from child registration lists used as the sampling frame. Paired RUAC and standard MUAC measurements were obtained from each child to assess agreement between the two methods. Children were classified as wasted using the MUAC cut-off value of < 12.5 cm, and RUAC was categorized using the same threshold. Data were analyzed using SPSS version 26. Agreement between RUAC and MUAC was evaluated using Cohen's Kappa for categorical measures and Bland-Altman analysis for continuous measurements. Diagnostic performance was assessed using sensitivity, specificity, positive predictive value, negative predictive value, and receiver operating characteristic (ROC) curve analysis. Assumptions for statistical analyses were checked before analysis. RESULTS: Among the participants, 61 (10.4%) children were classified as wasted using standard MUAC measurements. Significant agreement was observed between RUAC and standard MUAC classifications (kappa = 0.69; 95% CI: 0.60-0.79; p < 0.001). Using standard MUAC as the reference method, RUAC demonstrated a sensitivity of 81.6% (95% CI: 71.9%-89.0%) and specificity of 95.2% (95% CI: 93.1%-96.9%) for identifying wasting among children aged 6-59 months. The positive predictive value and negative predictive value of RUAC were 66.2% (95% CI: 55.0%-76.2%) and 97.8% (95% CI: 96.1%-98.9%), respectively. RUAC also demonstrated excellent diagnostic performance, with an area under the curve of 0.99 (95% CI: 0.98-0.99) for severe acute malnutrition and 0.94 (95% CI: 0.93-0.96) for moderate acute malnutrition. CONCLUSION: RUAC showed substantial agreement with standard MUAC and acceptable diagnostic performance for identifying wasting among children aged 6-59 months in Southwest Ethiopia. However, the evidence is limited to a single-site cross-sectional study, therefore, generalization beyond the study population is not justified. Further validation across different Ethiopian settings is recommended. CI - (c) 2026. The Author(s). FAU - Husen, Anuwar AU - Husen A AD - Masha Health Center, Sheka Zone, Southwest, Ethiopia. AD - Department of Nutrition and Dietetics, Faculty of Public Health, Institute of Health, Jimma University, Jimma, Ethiopia. FAU - Berhane, Anteneh AU - Berhane A AUID- ORCID: 0000-0001-5078-8703 AD - School of Public Health, College of Health and Medical Sciences, Haramaya University, Harer, Ethiopia. antishaction@gmail.com. FAU - Teshome, Melese Sinaga AU - Teshome MS AD - Department of Nutrition and Dietetics, Faculty of Public Health, Institute of Health, Jimma University, Jimma, Ethiopia. AD - Rehabilitation Research Centre (REVAL), Rehabilitation Sciences and Physiotherapy, Hasselt University, Wetenschapspark 7, Diepenbeek, 3590, Belgium. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260624 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Ethiopia MH - *Arm/anatomy & histology MH - Infant MH - Child, Preschool MH - Cross-Sectional Studies MH - Male MH - Female MH - *Anthropometry/methods MH - Reproducibility of Results MH - *Wasting Syndrome/diagnosis MH - Sensitivity and Specificity MH - Mass Screening/methods MH - Acute Disease PMC - PMC13560134 OTO - NOTNLM OT - Concordance OT - Correlation OT - Ethiopia OT - Mid-upper arm circumference OT - Random upper arm circumference OT - Validity OT - Wasting COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki and its later amendments. Ethical approval was obtained from the Institutional Review Board of Jimma University, Institute of Health (reference number JUIH/IRB/501/23). Permission to conduct the study was also obtained from the relevant local health authorities. Written informed consent was obtained from the legal guardians of all participating children to data collection. Participation was entirely voluntary, and caregivers were informed of their right to withdraw from the study at any time without any consequences. Confidentiality of the collected information was ensured by assigning anonymized identification codes and restricting data access to the research team only. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/25 06:37 MHDA- 2026/09/10 05:37 PMCR- 2026/06/24 CRDT- 2026/06/25 00:25 PHST- 2026/03/06 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/09/10 05:37 [medline] PHST- 2026/06/25 06:37 [pubmed] PHST- 2026/06/25 00:25 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.1186/s12887-026-07125-6 [pii] AID - 7125 [pii] AID - 10.1186/s12887-026-07125-6 [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 24;26(1):851. doi: 10.1186/s12887-026-07125-6. PMID- 42343232 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260911 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jun 25 TI - Predicting the risk of unplanned cesarean delivery at admission to guide labor process management: a retrospective cohort study in Southwest China. LID - 10.1186/s12884-026-09470-x [doi] LID - 1001 AB - BACKGROUND: Following the implementation of the three-child policy in China, an increasing number of pregnant people prefer vaginal delivery over cesarean delivery. However, concerns about unplanned cesarean delivery during labor have increased the demand for a quantitative risk assessment tool. Therefore, developing a prediction model tailored for pregnant Chinese people is essential for assisting clinical decision-making. OBJECTIVE: This study aimed to identify risk factors associated with unplanned cesarean delivery during a trial of labor and to develop a predictive model for determining this risk at admission. METHODS: This single-center retrospective cohort study analyzed 1,532 pregnant people with a term, singleton, cephalic pregnancy without a history of uterine surgery who were admitted for a trial of labor (April-December 2021). Of these, 138 underwent unplanned cesarean delivery and 1,394 achieved vaginal delivery. Predictors were selected via LASSO regression from an initial set of 13 candidate variables and used to build a multivariate logistic nomogram. The model was assessed by its AUC, sensitivity, specificity, accuracy, positive predictive value, negative predictive value and calibration (Hosmer-Lemeshow test). Clinical utility was evaluated via decision curve analysis, and internal validation was conducted via 1,000 bootstrap repetitions. RESULTS: Eight variables were identified as significant predictors of delivery mode: maternal height, maternal BMI, history of vaginal delivery, Bishop score at admission, premature rupture of membranes, gestational age, complications, and estimated fetal weight. The predictive model achieved an AUC of 0.811 (95% CI: 0.774-0.848). The Hosmer-Lemeshow test indicated P = 0.513. Internal validation yielded a mean AUC of 0.804 and a Brier score of 0.071, demonstrating good discrimination and calibration. CONCLUSION: A nomogram-based predictive model was developed to assess the risk of unplanned cesarean delivery during trial of labor. This model provides a quantitative tool to guide clinicians in risk assessment and optimize labor management, potentially reducing complications associated with unplanned cesarean deliveries. CI - (c) 2026. The Author(s). FAU - Yang, Zhuo AU - Yang Z AD - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Zhang, Huicong AU - Zhang H AD - Whiting School of Engineering, Johns Hopkins University, Baltimore, USA. FAU - Zheng, Yue AU - Zheng Y AD - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Chang, Shufang AU - Chang S AD - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Sun, Jiangchuan AU - Sun J AD - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. sunjiangchuan@126.com. LA - eng PT - Journal Article DEP - 20260625 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Retrospective Studies MH - *Cesarean Section/statistics & numerical data MH - China MH - Adult MH - *Trial of Labor MH - Risk Factors MH - Risk Assessment/methods MH - Nomograms PMC - PMC13555930 OTO - NOTNLM OT - Clinical decision-making OT - LASSO regression OT - Nomogram OT - Predictive factors OT - Risk prediction model OT - Unplanned cesarean delivery OT - Vaginal trial of labor COIS- Declarations. Ethics approval and consent to participate: The Ethics Committee of the Second Affiliated Hospital of Chongqing Medical University approved this study and waived the need for informed consent because of the retrospective nature of this study. The research was conducted according to the ethical standard of the Helsinki Declaration, and the patient data were stored anonymously in a dedicated database. All methods were carried out in accordance with relevant guidelines and regulations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/25 06:38 MHDA- 2026/09/09 07:07 PMCR- 2026/06/25 CRDT- 2026/06/25 00:24 PHST- 2025/09/09 00:00 [received] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/09/09 07:07 [medline] PHST- 2026/06/25 06:38 [pubmed] PHST- 2026/06/25 00:24 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.1186/s12884-026-09470-x [pii] AID - 9470 [pii] AID - 10.1186/s12884-026-09470-x [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jun 25;26(1):1001. doi: 10.1186/s12884-026-09470-x. PMID- 42342487 OWN - NLM STAT- Publisher LR - 20260727 IS - 1558-075X (Electronic) IS - 0146-0005 (Linking) VI - 50 IP - 5 DP - 2026 Aug TI - Standardizing outcome measures in preterm infant nutrition research: Use of anthropometry and body composition in the neonatal intensive care unit. PG - 152271 LID - S0146-0005(26)00060-1 [pii] LID - 10.1016/j.semperi.2026.152271 [doi] AB - Nutritional care and growth patterns in the neonatal intensive care unit (NICU) can impact lifelong health. Standardized measurement and reporting of growth outcomes are critical to improve the quality of information generated in research and population surveillance, facilitate comparisons and meta-analyses across individual studies, and strengthen the evidence used to generate clinical practice recommendations. Anthropometrics, specifically weight, length, and head circumference, are feasible and practical methods to monitor nutritional status. For research purposes, we recommend these anthropometrics be measured at birth (as a measure of fetal growth), 28 days old (to assess short-term growth), and 36 weeks postmenstrual age (PMA) (to determine the postnatal growth pattern in the NICU). We also encourage recording number of days to regain birthweight as a measure of short-term growth. Research publications should describe clearly the methods used to measure anthropometrics and reference curves used to calculate z-scores. Body composition is a complementary marker of nutritional status, but currently validated techniques have practical limitations in the NICU. When body composition tools are available, fat-free mass and fat mass should be measured at approximately 36 weeks PMA. We also describe key knowledge gaps and research priorities regarding growth patterns of preterm infants in the NICU. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Bell, Katherine A AU - Bell KA AD - Division of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: kbell7@bwh.harvard.edu. FAU - Calkins, Kara L AU - Calkins KL AD - Division of Neonatology, Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. FAU - Gollins, Laura A AU - Gollins LA AD - Department of Pediatrics, Division of Neonatology, Texas Children's Hospital, Houston, TX, USA. FAU - McNelis, Kera AU - McNelis K AD - Division of Neonatology, Department of Pediatrics, Emory University, Children's Healthcare of Atlanta, Atlanta, GA, USA. FAU - Strobel, Katie M AU - Strobel KM AD - Division of Neonatology, Department of Pediatrics, University of Washington, Seattle, WA, USA. LA - eng PT - Journal Article PT - Review DEP - 20260624 PL - United States TA - Semin Perinatol JT - Seminars in perinatology JID - 7801132 SB - IM OTO - NOTNLM OT - Anthropometrics OT - Body composition OT - Growth OT - Infant OT - Malnutrition OT - Neonate OT - Preterm COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Katherine Bell reports a relationship with National Institute of Child Health and Human Development that includes: funding grants. Katherine Bell reports a relationship with Allen Foundation Inc that includes: funding grants. Katie Strobel reports a relationship with National Institute of Child Health and Human Development that includes: funding grants. Katie Strobel reports a relationship with Gerber Foundation that includes: funding grants. Katie Strobel reports a relationship with University of Washington Nutrition Obesity Research Center that includes: funding grants. Katie Strobel reports a relationship with Robert W. Anderson Endowed Fund that includes: funding grants. Katie Strobel reports a relationship with NEC Society that includes: funding grants. Kera McNelis reports a relationship with National Institute of Diabetes and Digestive and Kidney Diseases that includes: funding grants. Kera McNelis reports a relationship with ELGAN Study (site PI) that includes: funding grants and travel reimbursement. Kara Calkins reports a relationship with Fresenius Kabi USA LLC that includes: consulting or advisory and funding grants. Kara Calkins reports a relationship with Mead Johnson Nutrition Company that includes: consulting or advisory, funding grants, and speaking and lecture fees. Kara Calkins reports a relationship with Baxter International Inc that includes: consulting or advisory. Kara Calkins reports a relationship with Premier Research that includes: funding grants. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/25 00:33 MHDA- 2026/06/25 00:33 CRDT- 2026/06/24 21:55 PHST- 2026/05/11 00:00 [received] PHST- 2026/06/09 00:00 [revised] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/06/25 00:33 [pubmed] PHST- 2026/06/25 00:33 [medline] PHST- 2026/06/24 21:55 [entrez] AID - S0146-0005(26)00060-1 [pii] AID - 10.1016/j.semperi.2026.152271 [doi] PST - ppublish SO - Semin Perinatol. 2026 Aug;50(5):152271. doi: 10.1016/j.semperi.2026.152271. Epub 2026 Jun 24. PMID- 42340201 OWN - NLM STAT- MEDLINE DCOM- 20260720 LR - 20260818 IS - 1728-0591 (Electronic) IS - 1728-0583 (Linking) VI - 37 IP - 2 DP - 2026 Aug TI - The associations between screen time and mental health in children aged 0-12: A systematic review. PG - 201-231 LID - 10.2989/17280583.2026.2661687 [doi] AB - BACKGROUND: : It is advised that children up to two years of age avoid any screen time (i.e., using digital screens), that those between the ages of two and five years should not exceed one hour per day, and that children aged five to 12 years should only have access to two hours of screen time per day. However, in the digital age, parents find it difficult to control the time their children spend on screens. AIM: : This article aimed to systematically synthesise the evidence on the associations between screen time and mental health outcomes in children aged 0 to 12 years. METHOD: : A systematic literature review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The search was defined according to the Population, Exposure, Comparator, and Outcomes (PECO) strategy, using the descriptors 'children', 'screen time' and 'mental health' when searching the databases PubMed, Scopus, and PsycINFO. Articles were included if they directly evaluated the associations between screen time and mental health, measured the results using validated instruments, included children aged 0 to 12 years, and were published since 2013. The Newcastle-Ottawa scale was used to check the methodological quality of the studies. The results were described by presenting the characteristics of the studies, the quality assessment, and the associations between screen time and mental health in longitudinal and cross-sectional studies. RESULTS: : This review assessed the quality of evidence and the frequency with which different mental health problems have been investigated in relation to screen time in children. Fifty-two studies were included, with most addressing attention deficit-hyperactivity disorder (n = 19), conduct problems (n = 13), externalising symptoms (n = 9), depression (n = 11), and anxiety (n = 9). Symptoms of attention deficit-hyperactivity disorder, oppositional defiant disorder, mood symptoms, emotional and social difficulties, conduct problems, low self-esteem, and sleep disturbances were positively associated with screen time, presenting evidence considered to be of high quality. LIMITATIONS: : Although this review concluded that screen time significantly affects children's mental health, some limitations should be noted. The lack of longitudinal data made it difficult to establish a clear causal relationship in most studies, and screen time measures may have introduced a potentia memory bias, as well as relying on parental recall. CONCLUSION: : Screen time warrants careful consideration in relation to children's mental health. Promoting off-screen activities may be crucial to reducing the risk of unfavourable mental health outcomes associated with exposure to the digital environment. Future research should focus on longitudinal studies to understand the causal relationships between children's psychosocial responses to the different purposes of screen use and the type of content to which they are exposed. FAU - Santos, Renata Maria Silva AU - Santos RMS AUID- ORCID: 0000-0001-5737-7712 AD - Federal University of Minas Gerais, Graduate Program Molecular Medicine, Belo Horizonte, Minas Gerais, Brazil. FAU - Ventura, Samara de Alcantara AU - Ventura SA AUID- ORCID: 0000-0003-4167-8961 AD - Federal University of Minas Gerais, Scientific Research Program Molecular Medicine, Belo Horizonte, Minas Gerais, Brazil. FAU - Goncalves, Maria Eduarda Oliveira de Albuquerque AU - Goncalves MEOA AUID- ORCID: 0009-0007-0839-9529 AD - Federal University of Minas Gerais, Scientific Research Program Molecular Medicine, Belo Horizonte, Minas Gerais, Brazil. FAU - Nogueira, Yago Jean de Almeida AU - Nogueira YJA AUID- ORCID: 0000-0001-6215-4310 AD - Federal University of Minas Gerais, Scientific Research Program Molecular Medicine, Belo Horizonte, Minas Gerais, Brazil. FAU - Mendes, Camila Guimaraes AU - Mendes CG AUID- ORCID: 0000-0001-8176-814X AD - Federal University of Minas Gerais, Graduate Program Children and Adolescent Health, Belo Horizonte, Minas Gerais, Brazil. FAU - Miranda, Debora Marques AU - Miranda DM AUID- ORCID: 0000-0002-7081-8401 AD - Federal University of Minas Gerais, Department of Pediatrics, Belo Horizonte, Minas Gerais, Brazil. FAU - Romano-Silva, Marco Aurelio AU - Romano-Silva MA AUID- ORCID: 0000-0002-6558-4639 AD - Federal University of Minas Gerais, Department of Psychiatry, Belo Horizonte, Minas Gerais, Brazil. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260624 PL - South Africa TA - J Child Adolesc Ment Health JT - Journal of child and adolescent mental health JID - 101242019 SB - IM MH - Child MH - Child, Preschool MH - Humans MH - Infant MH - Digital Media MH - Media Exposure MH - *Mental Health MH - *Screen Time MH - Male MH - Female MH - Infant, Newborn OTO - NOTNLM OT - children OT - media OT - mental health OT - screen time EDAT- 2026/06/24 12:36 MHDA- 2026/07/20 12:40 CRDT- 2026/06/24 09:53 PHST- 2026/07/20 12:40 [medline] PHST- 2026/06/24 12:36 [pubmed] PHST- 2026/06/24 09:53 [entrez] AID - 10.2989/17280583.2026.2661687 [doi] PST - ppublish SO - J Child Adolesc Ment Health. 2026 Aug;37(2):201-231. doi: 10.2989/17280583.2026.2661687. Epub 2026 Jun 24. PMID- 42339295 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260624 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - A novel nutritional tool to identify infants at risk of stunting. PG - 1782208 LID - 10.3389/fped.2026.1782208 [doi] LID - 1782208 AB - OBJECTIVE: This study aimed to develop and validate a novel scoring system and prediction algorithm integrating growth, nutritional, and biochemical indicators for the identification of infant stunting, defined as length-for-age Z-score < -2 standard deviations according to the World Health Organization (WHO) Child Growth Standards. METHODS: A retrospective cohort of 380 infants (aged 0-12 months) undergoing routine health examinations was enrolled. Participants were randomly allocated to a training set (n = 266) and a internal validation set (n = 114) in a 7:3 ratio. In the training set, univariate analysis identified candidate indicators (P < 0.05). Multivariate logistic regression and Least Absolute Shrinkage and Selection Operator (LASSO) regression were subsequently used to select independent predictors and prevent overfitting. Three machine learning models-Random Forest, Gradient Boosting, and Support Vector Machine-were constructed. Model performance was evaluated using the Area Under the Receiver Operating Characteristic Curve (AUC), calibration curves, and Decision Curve Analysis. Interpretability was assessed via SHapley Additive exPlanations (SHAP) values. A visual nomogram was developed. RESULTS: Baseline characteristics were comparable between the training and internal validation sets (P > 0.05). Five indicators were significantly associated with stunting, including infant weight Z-score, length Z-score, length growth velocity, diversity of complementary foods, and hemoglobin (Hb). Length growth velocity was the strongest predictor (OR=0.340, 95% CI: 0.211-0.548, P < 0.001). LASSO regression confirmed infant weight Z-score, length Z-score, length growth velocity, number of complementary food types, and Hb as the optimal variable combination. The Gradient Boosting model demonstrated superior performance, with an AUC of 0.861 (95% CI: 0.784-0.938) in the training set and 0.850 (95% CI: 0.699-1.000) in the internal validation set. Its calibration was excellent, and decision curve analysis indicated a higher net benefit across a wide risk threshold range. SHAP analysis identified infant weight Z-score as the most critical predictive variable. The nomogram provided a practical tool for quantitative risk assessment. CONCLUSION: The developed nutritional scoring system and Gradient Boosting prediction algorithm exhibited robust performance in identifying infants at risk of stunting. This tool facilitates early quantitative risk assessment and supports targeted clinical interventions. CI - (c) 2026 Wei, Su, Wei and Zhan. FAU - Wei, Qian AU - Wei Q AD - Department of Pediatrics, Affiliated Hospital of Hebei University, Baoding, Hebei Province, China. FAU - Su, Dandan AU - Su D AD - Department of Pediatrics, Affiliated Hospital of Hebei University, Baoding, Hebei Province, China. FAU - Wei, Jihong AU - Wei J AD - Department of Pediatrics, Affiliated Hospital of Hebei University, Baoding, Hebei Province, China. FAU - Zhan, Yaowu AU - Zhan Y AD - Department of Pediatrics, Affiliated Hospital of Hebei University, Baoding, Hebei Province, China. LA - eng PT - Journal Article DEP - 20260608 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13283820 OTO - NOTNLM OT - SHAP values OT - infant growth faltering OT - machine learning OT - nutritional scoring system OT - prediction algorithm COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/24 06:38 MHDA- 2026/06/24 06:39 PMCR- 2026/06/08 CRDT- 2026/06/24 04:45 PHST- 2026/01/06 00:00 [received] PHST- 2026/05/21 00:00 [revised] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/06/24 06:39 [medline] PHST- 2026/06/24 06:38 [pubmed] PHST- 2026/06/24 04:45 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - 10.3389/fped.2026.1782208 [doi] PST - epublish SO - Front Pediatr. 2026 Jun 8;14:1782208. doi: 10.3389/fped.2026.1782208. eCollection 2026. PMID- 42338068 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260813 IS - 2398-9238 (Electronic) IS - 2398-9238 (Linking) VI - 9 IP - 4 DP - 2026 Jul TI - Dietary Phytochemical Index and Its Relationship With Diminished Ovarian Reserve: Evidence From a Case-Control Study. PG - e70201 LID - 10.1002/edm2.70201 [doi] LID - e70201 AB - INTRODUCTION: Diminished ovarian reserve (DOR) represents a significant contributor to female infertility and adverse reproductive outcomes. Although diet may play a role, the specific impact of phytochemical-rich dietary patterns remains underexplored. So, we aimed to investigate the association between adherence to a dietary phytochemical index (DPI) and the likelihood of DOR among women attending fertility clinics. METHODS: This case-control study enrolled 370 women, comprising 120 individuals diagnosed with DOR and 250 age- and body mass index (BMI)-matched controls with normal ovarian reserve. A validated semi-quantitative food frequency questionnaire (FFQ) was applied to assess dietary intakes and, accordingly, DPI was calculated as the proportion of total energy intake obtained from phytochemical-abundant foods. Antral follicle count (AFC) and serum anti-Mullerian hormone (AMH) measurements were utilized as indicators of ovarian reserve. The association between DPI and the odds of DOR was investigated using multivariable logistic regression models. RESULTS: Our findings showed that higher DPI was associated with a reduced odds of DOR (Q4 vs. Q1 OR: 0.79; 95% CI: 0.55-0.93; p-trend = 0.010). After adjustment for physical activity and energy intake, the association remained significant (OR: 0.80; 95% CI: 0.54-0.95; p-trend = 0.033). In the fully adjusted model, which included additional adjustments for fat mass and body mass index, women in the highest DPI quartile had 27% lower odds of DOR compared to those in the lowest quartile (OR: 0.73; 95% CI: 0.42-0.97; p-trend = 0.02). Besides, in the control group, AFC differed significantly across DPI quartiles (p < 0.001), with the highest mean in the second quartile. CONCLUSION: Our findings suggest that a phytochemical-rich diet may help reduce the odds of DOR, highlighting the role of diet in reproductive health. However, further prospective studies and mechanistic research are warranted to confirm these results and clarify underlying pathways. CI - (c) 2026 The Author(s). Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd. FAU - Khodarahmi, Mahdieh AU - Khodarahmi M AUID- ORCID: 0000-0002-0689-6958 AD - Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Askari, Gholamreza AU - Askari G AD - Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Vajdi, Mahdi AU - Vajdi M AD - Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Mokari-Yamchi, Amin AU - Mokari-Yamchi A AD - Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran. FAU - Ghasemi-Tehrani, Hatav AU - Ghasemi-Tehrani H AD - Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Kalatehjari, Maryam AU - Kalatehjari M AD - Obstetrics & Gynecology Department, University of Washington, Seattle, USA. FAU - Ghavami, Abed AU - Ghavami A AD - Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. LA - eng GR - 2401257/Isfahan University of Medical Sciences/ PT - Journal Article PT - Observational Study PL - England TA - Endocrinol Diabetes Metab JT - Endocrinology, diabetes & metabolism JID - 101732442 RN - 0 (Phytochemicals) RN - 80497-65-0 (Anti-Mullerian Hormone) SB - IM MH - Case-Control Studies MH - *Diet/adverse effects/statistics & numerical data MH - *Phytochemicals/administration & dosage MH - *Ovarian Reserve/drug effects/physiology MH - *Eating/physiology MH - Humans MH - Female MH - Adult MH - Body Mass Index MH - Infertility, Female/epidemiology/etiology MH - Diet Surveys MH - Anti-Mullerian Hormone/blood MH - Ovarian Follicle/drug effects MH - Adolescent MH - Young Adult MH - Middle Aged PMC - PMC13291195 OTO - NOTNLM OT - dietary phytochemical index OT - diminished ovarian reserve OT - infertility OT - ovarian function OT - phytochemicals COIS- The authors declare no conflicts interest. EDAT- 2026/06/24 06:38 MHDA- 2026/06/25 00:33 PMCR- 2026/06/23 CRDT- 2026/06/24 02:23 PHST- 2026/02/08 00:00 [revised] PHST- 2025/11/04 00:00 [received] PHST- 2026/02/23 00:00 [accepted] PHST- 2026/06/25 00:33 [medline] PHST- 2026/06/24 06:38 [pubmed] PHST- 2026/06/24 02:23 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - EDM270201 [pii] AID - 10.1002/edm2.70201 [doi] PST - ppublish SO - Endocrinol Diabetes Metab. 2026 Jul;9(4):e70201. doi: 10.1002/edm2.70201. PMID- 42337511 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260916 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 24 TI - Nonlinear association between body mass index and physical fitness in primary school children: a single-school cross-sectional study using generalized additive models. LID - 10.1186/s12887-026-07226-2 [doi] LID - 843 AB - BACKGROUND: Body mass index (BMI) is associated with physical fitness in children, but the functional form of this relationship is debated. Using routinely collected fitness-monitoring data from a single primary school, this study examined whether BMI is nonlinearly associated with physical fitness in primary school children, treating the analysis as a methodological, single-school demonstration rather than a population-representative survey. METHODS: We analysed records from 1,572 students (808 boys, 764 girls; Grades 1-6) nested within 37 classes in one school in Tianfu New Area, Sichuan, China. BMI was calculated from measured height and weight. Four fitness indicators available for the whole sample-vital capacity, 50-m sprint, sit-and-reach, and 1-min rope skipping-were analysed as the primary outcomes; a composite index (mean of sex- and grade-standardised z-scores, with the 50-m sprint reverse-coded so that higher scores denote better fitness) was retained as a secondary descriptive summary. Quadratic regression and generalized additive models (GAMs; penalised cubic B-splines) adjusted for sex and grade were used to model BMI. Primary overall and sex-stratified models used cluster-robust standard errors at the class level; grade-stratified exploratory models, each based on only a few classes, were assessed with model-based smooth tests. Nonlinearity was quantified with the effective degrees of freedom (EDF) of the BMI smooth and a Wald test, and exploratory subgroup analyses were corrected for multiple comparisons (Benjamini-Hochberg false discovery rate, FDR). RESULTS: The class-level intraclass correlation was non-negligible for BMI (0.124) and the 50-m sprint (0.085), confirming the need to account for clustering. After cluster-robust adjustment, BMI showed a statistically supported nonlinear association with the 50-m sprint (EDF = 4.4, P < 0.001), 1-min rope skipping (EDF = 5.1, P < 0.001), and the composite index (EDF = 5.7, P < 0.001), but not with vital capacity (EDF = 1.0, P = 0.44). For the 50-m sprint the best predicted performance was well localised at a BMI of about 16.2 kg/m(2); for 1-min rope skipping the optimum was less precisely located, and for the composite index the cluster bootstrap did not identify a stable interior optimum (it spread the maximum across approximately 15.7-21.2 kg/m(2), with a median of approximately 19.7 kg/m(2) well above the full-sample point estimate). Predicted performance declined at both lower and higher BMI. The quadratic turning point (~ 18.5 kg/m(2)) was higher than the GAM peak and moved toward the GAM estimate when sparse BMI tails were trimmed, indicating sensitivity of the parabola to extreme values. In exploratory, FDR-corrected subgroup analyses, nonlinearity remained statistically supported in girls and in Grades 1 and 3 but not in boys or other grades; these subgroup findings are hypothesis-generating only. CONCLUSIONS: In this single-school sample, the BMI-fitness association was nonlinear for speed- and coordination-related tasks; for the 50-m sprint the best predicted performance was well localised at an intermediate BMI (about 16.2 kg/m(2)), whereas for the composite index no stable single optimum could be identified. Because the data come from one school and lack body-composition and physical-activity measures, the estimated optima are sample-specific descriptive features and should not be read as intervention targets. The study illustrates how routine school fitness data and GAMs can describe BMI-fitness patterns beyond categorical comparisons, and motivates multi-school, longitudinal confirmation. CI - (c) 2026. The Author(s). FAU - Zhu, Junhui AU - Zhu J AD - Faculty of Education, Universiti Kebangsaan Malaysia, Bangi, Malaysia. FAU - Zhao, Mingling AU - Zhao M AD - School of Urban Construction, Chengdu Polytechnic, Chengdu, China. FAU - Zheng, Meiling AU - Zheng M AD - Tianfu School of Tsinghua University High School, Meishan, China. FAU - Wang, Ling AU - Wang L AD - Faculty of Education, Universiti Kebangsaan Malaysia, Bangi, Malaysia. FAU - Li, Qiuyue AU - Li Q AD - School of Physical Education and Big Health, Sichuan Technology and Business University, Chengdu, China. 1039571063@qq.com. LA - eng PT - Journal Article DEP - 20260624 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Body Mass Index MH - *Physical Fitness/physiology MH - Male MH - Child MH - Cross-Sectional Studies MH - Female MH - China MH - Schools MH - Nonlinear Dynamics PMC - PMC13555981 OTO - NOTNLM OT - Body mass index OT - Children OT - Cluster-robust inference OT - Generalized additive models OT - Nonlinear association OT - Physical fitness OT - School health COIS- Declarations. Ethics approval and consent to participate: This study involving human participants was reviewed and approved by the Ethics Committee of Yibin University (Approval No. YBULLXS26041601). All procedures were performed in accordance with the Declaration of Helsinki and relevant guidelines and regulations. Written informed consent was obtained from the participants' legal guardians, and assent was obtained from the children where appropriate. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/24 06:37 MHDA- 2026/09/09 11:38 PMCR- 2026/06/24 CRDT- 2026/06/24 00:07 PHST- 2026/04/22 00:00 [received] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/09/09 11:38 [medline] PHST- 2026/06/24 06:37 [pubmed] PHST- 2026/06/24 00:07 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.1186/s12887-026-07226-2 [pii] AID - 7226 [pii] AID - 10.1186/s12887-026-07226-2 [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 24;26(1):843. doi: 10.1186/s12887-026-07226-2. PMID- 42336795 OWN - NLM STAT- MEDLINE DCOM- 20260624 LR - 20260813 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 10 IP - 1 DP - 2026 Jun 23 TI - Mealtime behaviours, diet quality and parental stress in children with autism spectrum disorder: a cross-sectional study from Turkiye. LID - 10.1136/bmjpo-2025-004226 [doi] LID - e004226 AB - BACKGROUND: Feeding difficulties in children with Autism Spectrum Disorder (ASD) are prevalent, adversely affecting both the child's nutritional status and the family's psychosocial well-being. This study aimed to examine the interrelationships between mealtime behaviours, diet quality and parental stress in children with ASD. METHODS: A cross-sectional study was conducted with 111 parents of children diagnosed with ASD (mean age: 6.8+/-3.5 years) in Antalya, Turkiye. Data were collected via face-to-face interviews using validated tools (Brief Autism Mealtime Behaviour Inventory (BAMBI), parental mealtime strategies, parental stress scale, Quality of Life questionnaire in autism). Diet quality was evaluated using the Healthy Eating Index-2020, derived from 3-day food consumption records. Multivariate linear regression was used to identify independent predictors of diet quality. RESULTS: The prevalence of poor diet quality was alarmingly high (94.5%). Multivariate regression revealed that problematic mealtime behaviours (BAMBI) were a strong independent predictor of lower diet quality (B=-0.370, p<0.001), even after adjusting for sociodemographic factors. While overall proactive parental strategies positively predicted diet quality, specific accommodative practices like preparing special meals correlated negatively. Furthermore, caregivers of girls reported significantly higher stress (p=0.017) and perceived autism-related burden (p=0.003) compared with caregivers of boys. CONCLUSIONS: Severe mealtime behavioural dysregulation in ASD intrinsically compromises diet quality and elevates parental psychosocial burden. Clinical management requires a multidisciplinary, family-centred approach integrating behavioural feeding support with caregiver stress management. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Ozyildirim, Caner AU - Ozyildirim C AUID- ORCID: 0000-0001-8227-9575 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Antalya, Turkey. FAU - Karacil Ermumcu, Merve Seyda AU - Karacil Ermumcu MS AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Antalya, Turkey. FAU - Mutlu, Meryem Ece AU - Mutlu ME AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Antalya, Turkey. FAU - Baran, Ilgin AU - Baran I AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Antalya, Turkey. FAU - Salim, Hediye AU - Salim H AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Antalya, Turkey. FAU - Seremet Kurklu, Nilgun AU - Seremet Kurklu N AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Antalya, Turkey nseremetkurklu@akdeniz.edu.tr. LA - eng PT - Journal Article DEP - 20260623 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Female MH - *Autism Spectrum Disorder/psychology MH - Child MH - *Stress, Psychological/epidemiology MH - *Feeding Behavior/psychology MH - *Parents/psychology MH - *Meals/psychology MH - Child, Preschool MH - Quality of Life MH - Surveys and Questionnaires MH - *Diet PMC - PMC13295970 OTO - NOTNLM OT - Child Health COIS- Competing interests: None declared. EDAT- 2026/06/24 00:43 MHDA- 2026/06/24 18:35 PMCR- 2026/06/23 CRDT- 2026/06/23 22:33 PHST- 2025/10/30 00:00 [received] PHST- 2026/05/30 00:00 [accepted] PHST- 2026/06/24 18:35 [medline] PHST- 2026/06/24 00:43 [pubmed] PHST- 2026/06/23 22:33 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - 10.1136/bmjpo-2025-004226 [pii] AID - bmjpo-2025-004226 [pii] AID - 10.1136/bmjpo-2025-004226 [doi] PST - epublish SO - BMJ Paediatr Open. 2026 Jun 23;10(1):e004226. doi: 10.1136/bmjpo-2025-004226. PMID- 42336570 OWN - NLM STAT- MEDLINE DCOM- 20260624 LR - 20260624 IS - 1001-0742 (Print) IS - 1001-0742 (Linking) VI - 166 DP - 2026 Aug TI - Associations between prenatal exposure to indoor air pollution and ambient particulate matter with infant growth. PG - 648-657 LID - S1001-0742(26)00041-0 [pii] LID - 10.1016/j.jes.2026.01.042 [doi] AB - Despite growing concern, the developmental effects of prenatal exposure to indoor and ambient particulate pollution remain poorly characterized. This study examined their individual and joint associations with infant growth. Embedded in the PKUBC-T birth cohort (initiated in June 2018, China), this study included 1068 mother-infant pairs. The PM(1) and PM(2.5) concentrations from the last menstrual period to delivery were predicted via a validated machine learning model, whereas PM(2.5) constituents' concentrations were derived via a modified Community Multiscale Air Quality Model. Indoor air pollution was assessed via questionnaires covering four dimensions. Infant growth was evaluated using body mass index (BMI) Z-scores and weight-for-length (WFL) Z-scores at one year, with overweight/obesity (OWOB) defined by World Health Organization standards. Generalized linear regression indicated that increased exposure to indoor air pollution was associated with elevated BMI Z-scores (beta = 0.089, 95 % CI: 0.007, 0.171) and WFL Z-scores (beta = 0.094, 95 % CI: 0.013, 0.176) in offspring. PM(1) and PM(2.5) also exhibited positive associations with these growth indicators. Infants whose mothers were exposed to higher levels of organic carbon (OC), elementary carbon (EC), NH(4)(+) and SO(4)(2-) had an elevated risk of overweight/obesity (OWOB). Stratified analyses revealed that joint exposure to PM(1) above the median and indoor air pollution was related to increased infant growth, despite nonsignificant multiplicative interaction effects. Similar joint effects were observed for indoor air pollution and PM(2.5), along with its constituents. This study highlights synergistic harms of combined indoor-outdoor air pollution on infant growth, reinforcing the need for integrated policies targeting indoor combustion and ambient PM reduction to safeguard early-life development. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Lyu, Jinlang AU - Lyu J AD - Department of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing 100191, China; Peking University Health Science Center-Weifang Joint Research Center for Maternal and Child Health, Beijing 100191, China. FAU - Li, Tiantian AU - Li T AD - China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China. FAU - Zhou, Shuang AU - Zhou S AD - Department of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing 100191, China. FAU - Yuan, Xin AU - Yuan X AD - Department of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing 100191, China; Peking University Health Science Center-Weifang Joint Research Center for Maternal and Child Health, Beijing 100191, China. FAU - Bao, Zheng AU - Bao Z AD - Tongzhou Maternal and Child Health Care Hospital of Beijing, Beijing 101101, China. FAU - Han, Na AU - Han N AD - Tongzhou Maternal and Child Health Care Hospital of Beijing, Beijing 101101, China. FAU - Chen, Gongbo AU - Chen G AD - Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne 3800, Australia. FAU - Ji, Yuelong AU - Ji Y AD - Department of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing 100191, China; Peking University Health Science Center-Weifang Joint Research Center for Maternal and Child Health, Beijing 100191, China. FAU - Li, Qin AU - Li Q AD - Department of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing 100191, China; Peking University Health Science Center-Weifang Joint Research Center for Maternal and Child Health, Beijing 100191, China. FAU - Liu, Jue AU - Liu J AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Wang, Hui AU - Wang H AD - Department of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing 100191, China; Peking University Health Science Center-Weifang Joint Research Center for Maternal and Child Health, Beijing 100191, China. FAU - Hu, Jianlin AU - Hu J AD - Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, Nanjing University of Information Science & Technology, Nanjing 210044, China. FAU - Liu, Ting AU - Liu T AD - Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, Nanjing University of Information Science & Technology, Nanjing 210044, China. FAU - Guo, Yuming AU - Guo Y AD - Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne 3800, Australia. FAU - Li, Yan AU - Li Y AD - Research Center for Child Health, Department of Child Health Care, Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Qingdao, Shandong 250014, China. FAU - Wang, Hai-Jun AU - Wang HJ AD - Department of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing 100191, China; Peking University Health Science Center-Weifang Joint Research Center for Maternal and Child Health, Beijing 100191, China. Electronic address: whjun@pku.edu.cn. LA - eng PT - Journal Article DEP - 20260120 PL - Netherlands TA - J Environ Sci (China) JT - Journal of environmental sciences (China) JID - 100967627 RN - 0 (Particulate Matter) RN - 0 (Air Pollutants) SB - IM MH - Humans MH - *Particulate Matter/analysis/adverse effects MH - *Air Pollution, Indoor/statistics & numerical data/adverse effects MH - Female MH - *Maternal Exposure/statistics & numerical data MH - *Air Pollutants/analysis MH - Infant MH - China/epidemiology MH - Pregnancy MH - *Prenatal Exposure Delayed Effects/epidemiology MH - *Child Development/drug effects OTO - NOTNLM OT - Adiposity OT - Air pollution OT - Indoor OT - Infant OT - PM(1) OT - PM(2.5) COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/24 00:45 MHDA- 2026/06/25 00:33 CRDT- 2026/06/23 20:54 PHST- 2025/07/17 00:00 [received] PHST- 2026/01/16 00:00 [revised] PHST- 2026/01/17 00:00 [accepted] PHST- 2026/06/25 00:33 [medline] PHST- 2026/06/24 00:45 [pubmed] PHST- 2026/06/23 20:54 [entrez] AID - S1001-0742(26)00041-0 [pii] AID - 10.1016/j.jes.2026.01.042 [doi] PST - ppublish SO - J Environ Sci (China). 2026 Aug;166:648-657. doi: 10.1016/j.jes.2026.01.042. Epub 2026 Jan 20. PMID- 42335117 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260623 IS - 1533-4287 (Electronic) IS - 1064-8011 (Linking) VI - 40 IP - 7 DP - 2026 Jul 1 TI - Improving Base Running Diagnostics With Foot Pod Technology: Intersession Reliability of Linear and Curvilinear Running Performance. PG - e714-e720 LID - 10.1519/JSC.0000000000005417 [doi] AB - Martinez-Rodriguez, JA, Crotin, RL, Neville, J, Barcelo, RA, and Cronin, JB. Improving base running diagnostics with foot pod technology: Intersession reliability of linear and curvilinear running performance. J Strength Cond Res 40(7): e714-e720, 2026-The purpose of this study was to determine the intersession reliability of foot pod technology for quantifying kinematic measures over the 54.7-m straight-line sprint (linear) and home-to-second base sprint (curvilinear). Twelve, trained male high school baseball position players, performed 3 identical sessions separated by at least 2 days. Eight kinematic measures (maximum speed, average speed and right and left ground contact time, stride length, push-off, and impact) were quantified over 2 linear and 2 curvilinear trials, which were divided into segments-home to first, first to second, and home to second, for a total of 60 comparisons across 3 testing occasions. There was no evidence (p > 0.05) of systematic change in any of the variables between sessions, with 91% of the mean percent changes <2%. In terms of absolute consistency, 94% of coefficients of variation (CVs) were under 10%, with 63% of the CVs under 5%. Regarding relative consistency, for the curvilinear segments 1 and 2, and total segment, 80, 56, and 80% of the between-session comparisons had intraclass correlation coefficients (ICC) greater than 0.74, respectively. The nonsignificant small percentage changes in the mean, low CVs, and good to excellent reliability of the ICCs for the most part indicate that foot pod technology can be used to reliably quantify linear and curvilinear base running performance measures with confidence. Consequently, this information can be used to better quantify base running efficiency and inform exercise prescription to improve base running performance. CI - Copyright (c) 2026 National Strength and Conditioning Association. FAU - Martinez-Rodriguez, Jose Antonio AU - Martinez-Rodriguez JA AUID- ORCID: 0000-0001-8338-2873 AD - Sport Performance Research Institute New Zealand, Auckland University of Technology, Auckland, New Zealand. FAU - Crotin, Ryan L AU - Crotin RL AD - Sport Performance Research Institute New Zealand, Auckland University of Technology, Auckland, New Zealand. AD - Department of Kinesiology, Louisiana Tech University, Ruston, Louisiana. AD - ArmCare.com, Indialantic, Florida; and. FAU - Neville, Jonathon AU - Neville J AD - Sport Performance Research Institute New Zealand, Auckland University of Technology, Auckland, New Zealand. FAU - Barcelo, Roderick A AU - Barcelo RA AD - Athletic Department, Carlos Beltran Baseball Academy, Florida, Puerto Rico. FAU - Cronin, John B AU - Cronin JB AD - Sport Performance Research Institute New Zealand, Auckland University of Technology, Auckland, New Zealand. AD - Athlete Training and Health, Houston, Texas. LA - eng PT - Journal Article DEP - 20260304 PL - United States TA - J Strength Cond Res JT - Journal of strength and conditioning research JID - 9415084 SB - IM MH - Humans MH - *Running/physiology MH - Male MH - Biomechanical Phenomena MH - Reproducibility of Results MH - *Athletic Performance/physiology MH - Adolescent MH - *Baseball/physiology MH - Foot/physiology OTO - NOTNLM OT - high-frequency technology OT - kinematic measures EDAT- 2026/06/23 18:34 MHDA- 2026/06/23 18:35 CRDT- 2026/06/23 13:35 PHST- 2026/06/23 18:35 [medline] PHST- 2026/06/23 18:34 [pubmed] PHST- 2026/06/23 13:35 [entrez] AID - 00124278-202607000-00018 [pii] AID - 10.1519/JSC.0000000000005417 [doi] PST - ppublish SO - J Strength Cond Res. 2026 Jul 1;40(7):e714-e720. doi: 10.1519/JSC.0000000000005417. Epub 2026 Mar 4. PMID- 42334852 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260826 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 9 IP - 6 DP - 2026 Jun 1 TI - Maternal Cardiovascular Health During Pregnancy and Offspring Developmental Delay. PG - e2618804 LID - 10.1001/jamanetworkopen.2026.18804 [doi] LID - e2618804 AB - IMPORTANCE: Developmental delay affects daily living, social functioning, and mental health. Maternal cardiovascular health (CVH) during pregnancy may indicate an adverse intrauterine environment, but its association with developmental delay is unclear. OBJECTIVE: To examine the association between maternal CVH during pregnancy and developmental delay in offspring at 4 years of age. DESIGN, SETTING, AND PARTICIPANTS: This cohort study enrolled patients between July 19, 2013, and March 31, 2017, with 5 years of follow-up, at obstetric hospitals and clinics in Miyagi Prefecture, Japan. Participants included eligible mother and offspring pairs enrolled in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Offspring were followed up until age 4 years. Data analyses were conducted from November 12, 2024, to March 24, 2026. EXPOSURE: Maternal CVH during pregnancy, which was assessed using Life's Essential 8 metrics (diet, physical activity, nicotine exposure, sleep health, body mass index, blood lipids, blood glucose, and blood pressure). Each metric was scored on a scale of 0 (least favorable) to 100 (most favorable), and these scores were used to categorize mothers as having high (80-100), moderate (50-79), or low (0-49) CVH. MAIN OUTCOMES AND MEASURES: Developmental delay at age 4 years, which was evaluated by the mother using the validated Japanese version of Ages and Stages Questionnaire, Third Edition. This instrument has 5 domains: communication, gross motor, fine motor, problem solving, and personal-social skills. Domain-specific delay was defined as 2 or more SDs below the mean score, and developmental delay in total was defined as delay in 1 or more of the 5 domains. RESULTS: Among 19 160 eligible mother and offspring pairs, 8238 (43.0%) were analyzed. Offspring were assessed at a mean (SD) age of 4.1 (0.2) years and included 4299 males (52.2%). Among mothers with high, moderate, and low CVH, 154 (8.8%), 763 (12.1%), and 33 (16.8%), respectively, had offspring with developmental delay in total. Compared with high CVH, moderate (risk ratio [RR], 1.30; 95% CI, 1.09-1.54) and low (RR, 1.62; 95% CI, 1.11-2.36) CVH during pregnancy were associated with developmental delay in total. Low CVH was associated with higher prevalence of developmental delay across all 5 domains, with personal-social domain having the largest effect size (RR, 2.23; 95% CI, 1.23-4.07; P for trend = .002) and communication domain having the smallest effect size (RR, 1.40; 95% CI, 0.69-2.85; P for trend = .03). CONCLUSIONS AND RELEVANCE: In this cohort study of mother and offspring pairs in Japan, better maternal CVH during pregnancy was associated with a lower risk of offspring developmental delay at age 4 years. FAU - Ohseto, Hisashi AU - Ohseto H AD - Division of Disaster Public Health, International Research Institute of Disaster Science, Tohoku University, Sendai, Miyagi, Japan. FAU - Ishikuro, Mami AU - Ishikuro M AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. FAU - Chen, Geng AU - Chen G AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. FAU - Takahashi, Ippei AU - Takahashi I AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. FAU - Shinoda, Genki AU - Shinoda G AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. FAU - Noda, Aoi AU - Noda A AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Miyagi, Japan. FAU - Murakami, Keiko AU - Murakami K AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Health and Social Behavior, School of Public Health, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. FAU - Orui, Masatsugu AU - Orui M AD - Division of Disaster Public Health, International Research Institute of Disaster Science, Tohoku University, Sendai, Miyagi, Japan. AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. FAU - Takase, Masato AU - Takase M AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. FAU - Iwama, Noriyuki AU - Iwama N AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. AD - Center for Maternal and Perinatal Medicine, Tohoku University Hospital, Sendai, Miyagi, Japan. FAU - Kikuya, Masahiro AU - Kikuya M AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Hygiene and Public Health, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan. FAU - Metoki, Hirohito AU - Metoki H AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. AD - Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan. FAU - Hozawa, Atsushi AU - Hozawa A AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. AD - Division of Epidemiology, School of Public Health, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. FAU - Obara, Taku AU - Obara T AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Miyagi, Japan. FAU - Kuriyama, Shinichi AU - Kuriyama S AD - Division of Disaster Public Health, International Research Institute of Disaster Science, Tohoku University, Sendai, Miyagi, Japan. AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260601 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Adult MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Pregnancy MH - Cohort Studies MH - *Developmental Disabilities/epidemiology/etiology MH - *Developmental Origins of Health and Disease/epidemiology MH - Japan/epidemiology MH - *Maternal Health/statistics & numerical data PMC - PMC13291893 COIS- Conflict of Interest Disclosures: Dr Ishikuro reported receiving grants from Japan Agency for Medical Research and Development and the Ministry of Education, Culture, Sports, Science, and Technology during the conduct of the study. No other disclosures were reported. EDAT- 2026/06/23 12:35 MHDA- 2026/06/23 18:34 PMCR- 2026/06/23 CRDT- 2026/06/23 11:33 PHST- 2026/06/23 18:34 [medline] PHST- 2026/06/23 12:35 [pubmed] PHST- 2026/06/23 11:33 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - 2850602 [pii] AID - zoi260523 [pii] AID - 10.1001/jamanetworkopen.2026.18804 [doi] PST - epublish SO - JAMA Netw Open. 2026 Jun 1;9(6):e2618804. doi: 10.1001/jamanetworkopen.2026.18804. PMID- 42334526 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260922 IS - 2210-6014 (Electronic) IS - 2210-6006 (Print) IS - 2210-6006 (Linking) VI - 16 IP - 1 DP - 2026 Jun 23 TI - Anemia and Cardiometabolic Risk in Indian University Students: Findings from a Health Screening Program. LID - 10.1007/s44197-026-00597-w [doi] LID - 111 AB - BACKGROUND: College students represent a population that is considered clinically at low risk; yet, early adulthood constitutes a crucial time point when nutritional and metabolic risks manifest themselves. This retrospective observational study evaluated anemia, blood pressure, and body mass index (BMI) characteristics of college students undergoing a health screening examination organized by their university in India. METHODS: Anonymized electronic health records were analyzed for 13,628 college students between the ages of 18 and 30 years old attending annual health screening from 1 June 2023 to 31 May 2024. The sample consisted of 77.2% of the eligible students. BMI, blood pressure, and hemoglobin levels were classified according to international standards. Gender-based differences were explored through chi-square tests and Cramer's V measures. Association between anemia and screening-confirmed hypertension was assessed using Pearson correlations and multiple logistic regression. In addition, model discrimination, calibration, classification parameters, and internal validation were evaluated. RESULTS: There were 7,012 (51.5%) female students and 6,616 (48.5%) male students in the sample population. In total, 47.3% of the students were either overweight or obese, 8,081 (59.3%) fulfilled the criteria for high blood pressure according to the ACC/AHA guidelines, while 7,227 (53.0%) fulfilled WHO guidelines for anemia based on gender. Hypertension screening was also more common among men (66.6%) compared to women (52.4%; p < 0.001). In the adjusted models, being male was significantly linked with anemia and hypertension screening, while being overweight was significantly linked with hypertension screening. CONCLUSION: This study showed the high prevalence of undiagnosed anemia and cardiometabolic risks among university students, suggesting the importance of health promoting universities in systematic screening programs and follow-ups. CI - (c) 2026. The Author(s). FAU - Yeravdekar, Rajiv AU - Yeravdekar R AD - Faculty of Medical & Health Sciences, Symbiosis International (Deemed University), Gram Lavale, Pune, Maharashtra, India. FAU - Chandak, Alaka AU - Chandak A AD - Symbiosis Institute of Health Sciences (SIHS), Symbiosis International (Deemed University), Pune, Maharashtra, India. dralaka@sihs.edu.in. AD - , Pune, India. dralaka@sihs.edu.in. LA - eng PT - Journal Article PT - Observational Study DEP - 20260623 PL - Switzerland TA - J Epidemiol Glob Health JT - Journal of epidemiology and global health JID - 101592084 SB - IM MH - Humans MH - Male MH - Female MH - *Students/statistics & numerical data MH - Universities MH - Retrospective Studies MH - Adult MH - Young Adult MH - India/epidemiology MH - *Anemia/epidemiology MH - Mass Screening MH - Adolescent MH - Body Mass Index MH - *Hypertension/epidemiology MH - *Cardiometabolic Risk Factors MH - Blood Pressure PMC - PMC13575005 OTO - NOTNLM OT - Anemia OT - Cardiometabolic risks OT - Electronic medical records OT - Health promoting universities OT - High blood pressure OT - Student health OT - Universities COIS- Declarations. Ethical approval: Ethics approval was obtained from the Institutional Ethics Committee of Symbiosis International (Deemed University), Approval No. SIU/IEC/1137. Consent to participate: The requirement for individual informed consent was waived by the Institutional Ethics Committee because the study used anonymized retrospective EHR data. Competing interests: The authors declare no competing interests. EDAT- 2026/06/23 12:36 MHDA- 2026/09/15 05:36 PMCR- 2026/06/23 CRDT- 2026/06/23 11:05 PHST- 2026/03/18 00:00 [received] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/09/15 05:36 [medline] PHST- 2026/06/23 12:36 [pubmed] PHST- 2026/06/23 11:05 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - 10.1007/s44197-026-00597-w [pii] AID - 597 [pii] AID - 10.1007/s44197-026-00597-w [doi] PST - epublish SO - J Epidemiol Glob Health. 2026 Jun 23;16(1):111. doi: 10.1007/s44197-026-00597-w. PMID- 42334123 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260905 IS - 1098-240X (Electronic) IS - 0160-6891 (Print) IS - 0160-6891 (Linking) VI - 49 IP - 5 DP - 2026 Oct TI - The Psychometric Properties of the Caregiver Feeding Style Questionnaire: A Cross-Cultural Validation in Spanish Parents. PG - 657-667 LID - 10.1002/nur.70093 [doi] AB - Parental feeding styles are a key dimension of parent-child interactions during mealtimes and have a significant influence on children's development. Through their impact on children's eating behaviours, these styles are a key focus for enhancing the well-being of both the child and the family as a whole. This study aimed to cross-culturally adapt, translate, and validate the Caregiver Feeding Style Questionnaire (CFSQ) in a Spanish sample. This is a cross-sectional study that conducted in a Spanish cohort. Data were collected at four time points, from hospital discharge until the children were aged 7-10 years old. As part of the CFSQ validation study, the original English version underwent linguistic validation, which included 20 cognitive interviews with parents. Confirmatory factor analysis (CFA) of the CFSQ was then conducted using the cohort sample. A total of 194 Spanish parents of children aged 7-10 years old completed the CFSQ. Some items were slightly modified to improve cultural adaptation. Two CFA models were tested: a bidimensional and a unidimensional model. Both showed acceptable fit indices: bidimensional model -X(2) = 3,385.28 (df = 171; p < 0.001), CFI = 0.902, TLI = 0.889, RMSEA = 0.104 (90%CI 0.094-0.115), and SRMR = 0.09; unidimensional model- X(2) = 2,714.22 (df = 78; p < 0.001), CFI = 0.880, TLI = 0.900, RMSEA = 0.145 (90%CI 0.130-0.161), and SRMR = 0.094-. Both models demonstrated adequate internal consistency. In conclusion, the Spanish version of the CFSQ showed adequate structural validity and psychometric properties. While both models were acceptable, the shorter unidimensional version is preferable due to its parsimony and performance. CI - (c) 2026 The Author(s). Research in Nursing & Health published by Wiley Periodicals LLC. FAU - Lozano-Casanova, Mar AU - Lozano-Casanova M AD - Nursing Department, Faculty of Health Sciences, University of Alicante, Alicante, Spain. FAU - Escribano, Silvia AU - Escribano S AD - Nursing Department, Faculty of Health Sciences, University of Alicante, Alicante, Spain. FAU - Oliver-Roig, Antonio AU - Oliver-Roig A AUID- ORCID: 0000-0001-9171-820X AD - Nursing Department, Faculty of Health Sciences, University of Alicante, Alicante, Spain. FAU - Gutierrez-Hervas, Ana AU - Gutierrez-Hervas A AUID- ORCID: 0000-0003-3210-7200 AD - Nursing Department, Faculty of Health Sciences, University of Alicante, Alicante, Spain. FAU - Richart-Martinez, Miguel AU - Richart-Martinez M AD - Nursing Department, Faculty of Health Sciences, University of Alicante, Alicante, Spain. FAU - Sospedra, Isabel AU - Sospedra I AD - Nursing Department, Faculty of Health Sciences, University of Alicante, Alicante, Spain. LA - eng GR - PI14/01549/Instituto de Salud Carlos III/ GR - GRE21-08B/Universidad de Alicante/ PT - Journal Article PT - Validation Study DEP - 20260623 PL - United States TA - Res Nurs Health JT - Research in nursing & health JID - 7806136 SB - IM MH - Humans MH - Child MH - Psychometrics MH - Spain MH - Surveys and Questionnaires/standards MH - Female MH - Cross-Sectional Studies MH - Male MH - Cross-Cultural Comparison MH - Reproducibility of Results MH - *Feeding Behavior/psychology MH - *Parents/psychology MH - *Parent-Child Relations MH - Adult MH - *Caregivers/psychology PMC - PMC13539630 COIS- The authors declare no conflicts of interest. EDAT- 2026/06/23 12:34 MHDA- 2026/09/03 17:36 PMCR- 2026/09/03 CRDT- 2026/06/23 08:32 PHST- 2026/05/18 00:00 [revised] PHST- 2025/11/23 00:00 [received] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/09/03 17:36 [medline] PHST- 2026/06/23 12:34 [pubmed] PHST- 2026/06/23 08:32 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - NUR70093 [pii] AID - 10.1002/nur.70093 [doi] PST - ppublish SO - Res Nurs Health. 2026 Oct;49(5):657-667. doi: 10.1002/nur.70093. Epub 2026 Jun 23. PMID- 42334025 OWN - NLM STAT- Publisher LR - 20260623 IS - 1600-0528 (Electronic) IS - 0301-5661 (Linking) DP - 2026 Jun 23 TI - Implementation of Child Healthy Weight Guidelines in the Dental Setting: A Pilot Study. LID - 10.1111/cdoe.70088 [doi] AB - BACKGROUND: There has been an increasing prevalence of childhood overweight and obesity worldwide and locally, with a quarter of Australian children now considered overweight. To address this, the New South Wales government in Australia released guidelines calling for all public dental services to identify children above a healthy weight and refer them to appropriate services. This study was part of a larger study that aimed to codesign and pilot implementation strategies to facilitate the translation of these guidelines into dental staff's practice. METHODS: A pre-post-test design was used to evaluate the strategies across two health districts in NSW. Strategies were codesigned by dental staff and parents of patients and included linguistically appropriate resources; discharge summaries from referral pathways; refresher training; involvement of dental assistants; templates for longitudinal BMI measures and growth assessment flyers for patients. A validated questionnaire measuring intention to engage in the guidelines and self-reported practice was distributed to interested staff before and after the delivery of strategies (2019-2022). Data describing dental staff's' actual practices over this time were also retrieved from patient information management systems. Descriptive and inferential statistics were used to assess the study outcomes and any differences across districts (n = 16). RESULTS: There was no improvement in behavioural determinants of providing a growth assessment as indicated by the overall intention to engage in Children's Healthy Weight guideline (iCHEW) scale scores, however attitude scores had the largest observed improvement (from 30.1 to 35.2) and this was most pronounced in District 2 (27.2-34.3). A significant improvement in adherence to children's healthy weight guidelines was also seen in District 2 (increase of 20.54%, 95% CI 14.09-27.44). In District 1, children had 1.5 times the odds of receiving a growth assessment if they were treated by a dental officer (OR = 1.54; 95% CI 1.00-1.72). Conversely, children in District 2 had significantly lower odds of receiving a growth assessment if they were treated by a dental officer (OR = 0.203; 95% CI 0.12-0.35) or if they were treated at a satellite clinic (OR = 0.572; 95% CI 0.45-0.73). CONCLUSION: Dental staff can play a key role in addressing childhood overweight and obesity, although this can be challenging. The findings suggested some improvements in behavioural determinants and self-reported behaviours following supportive strategies. Further research to confirm these findings using larger sample sizes is recommended. CI - (c) 2026 The Author(s). Community Dentistry and Oral Epidemiology published by John Wiley & Sons Ltd. FAU - Villarosa, Amy R AU - Villarosa AR AUID- ORCID: 0000-0003-3198-472X AD - Australian Centre for Integration of Oral Health (ACIOH), School of Nursing & Midwifery, Western Sydney University, Sydney, New South Wales, Australia. AD - National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australian Capital Territory, Australia. AD - Ingham Institute for Applied Medical Research, Sydney, New South Wales, Australia. FAU - Maneze, Della AU - Maneze D AUID- ORCID: 0000-0001-6475-8804 AD - Australian Centre for Integration of Oral Health (ACIOH), School of Nursing & Midwifery, Western Sydney University, Sydney, New South Wales, Australia. AD - School of Nursing, University of Wollongong, Wollongong, New South Wales, Australia. FAU - Ramjan, Lucie AU - Ramjan L AUID- ORCID: 0000-0001-7815-3005 AD - Australian Centre for Integration of Oral Health (ACIOH), School of Nursing & Midwifery, Western Sydney University, Sydney, New South Wales, Australia. AD - Ingham Institute for Applied Medical Research, Sydney, New South Wales, Australia. AD - School of Nursing, University of Wollongong, Wollongong, New South Wales, Australia. FAU - Patterson-Norrie, Tiffany AU - Patterson-Norrie T AD - Australian Centre for Integration of Oral Health (ACIOH), School of Nursing & Midwifery, Western Sydney University, Sydney, New South Wales, Australia. AD - Ingham Institute for Applied Medical Research, Sydney, New South Wales, Australia. AD - School of Medicine, Faculty of Health, Western Sydney University, Sydney, New South Wales, Australia. FAU - Srinivas, Ravi AU - Srinivas R AD - Australian Centre for Integration of Oral Health (ACIOH), School of Nursing & Midwifery, Western Sydney University, Sydney, New South Wales, Australia. AD - Ingham Institute for Applied Medical Research, Sydney, New South Wales, Australia. AD - Oral Health Services, South Western Sydney Local Health District, Sydney, New South Wales, Australia. AD - School of Dentistry, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. FAU - Yaacoub, Albert AU - Yaacoub A AD - Australian Centre for Integration of Oral Health (ACIOH), School of Nursing & Midwifery, Western Sydney University, Sydney, New South Wales, Australia. AD - School of Dentistry, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. AD - Oral Health Services, Nepean Blue Mountains Local Health District, Sydney, New South Wales, Australia. FAU - Kumar, Tanya AU - Kumar T AD - School of Dentistry, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. AD - Oral Health Services, Nepean Blue Mountains Local Health District, Sydney, New South Wales, Australia. FAU - George, Ajesh AU - George A AUID- ORCID: 0000-0002-6795-2546 AD - Australian Centre for Integration of Oral Health (ACIOH), School of Nursing & Midwifery, Western Sydney University, Sydney, New South Wales, Australia. AD - Ingham Institute for Applied Medical Research, Sydney, New South Wales, Australia. AD - School of Nursing, University of Wollongong, Wollongong, New South Wales, Australia. AD - School of Dentistry, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. LA - eng GR - GNT1168119/National Health and Medical Research Council/ GR - GNT1168119/Western Sydney University/ PT - Journal Article DEP - 20260623 PL - Denmark TA - Community Dent Oral Epidemiol JT - Community dentistry and oral epidemiology JID - 0410263 SB - IM OTO - NOTNLM OT - dental staff OT - dentist OT - guidelines OT - implementation OT - oral health EDAT- 2026/06/23 12:35 MHDA- 2026/06/23 12:35 CRDT- 2026/06/23 08:13 PHST- 2026/04/07 00:00 [revised] PHST- 2024/11/05 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/06/23 12:35 [medline] PHST- 2026/06/23 12:35 [pubmed] PHST- 2026/06/23 08:13 [entrez] AID - 10.1111/cdoe.70088 [doi] PST - aheadofprint SO - Community Dent Oral Epidemiol. 2026 Jun 23. doi: 10.1111/cdoe.70088. PMID- 42332636 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260908 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jun 23 TI - Bridging Respiratory Exposures, Asthma, and Environmental Health in Corpus Christi (BREATHE-CC): a prospective cohort study protocol. LID - 10.1186/s12889-026-28265-5 [doi] LID - 2521 AB - BACKGROUND: Childhood asthma disproportionately affects Hispanic children in the United States. Nevertheless, few longitudinal cohorts exist in Gulf Coast communities where environmental exposures may compound sociodemographic vulnerabilities. Corpus Christi, a majority-Hispanic city with high levels of petrochemical industrial operations, reports higher asthma prevalence than state and national averages. BREATHE-CC (Bridging Respiratory Exposures, Asthma, and Environmental Health in Corpus Christi) is a prospective cohort designed to investigate the role of air pollutants, household conditions, and social determinants of health in asthma exacerbations and wheezing phenotypes. METHODS: Approximately 200 children less than 10 years of age with asthma will be enrolled from Driscoll Children's Hospital. Enrolled participants complete baseline assessments and are followed monthly for up to 18 months using a parent-reported modified ISAAC (International Study of Asthma and Allergies in Childhood) questionnaire that captures household exposures, asthma exacerbations, and wheezing episodes. Questionnaire responses will be validated and supplemented with electronic health record (EHR) reviews. Daily air pollutant concentrations (PM(2.5), PM(10), O(3), SO(2)) from the Texas Commission on Environmental Quality (TCEQ) and U.S. Environmental Protection Agency (EPA) monitoring stations will be linked to participants' addresses. Generalized Additive Models (GAMs) and Poisson regressions will assess the associations between air pollutant exposures, household risk factors, asthma exacerbations, and wheezing phenotypes, adjusting for age, sex, body mass index (BMI), and other sociodemographic indicators. Group-Based Trajectory Modeling (GBTM) will identify latent phenotypes of wheezing. DISCUSSION: This is a longitudinal cohort examining Hispanic children residing in the Gulf Coast petrochemical corridor. In particular, the study integrates granular geospatial environmental monitoring to link daily air pollutant exposure levels with asthma exacerbation risk. GBTM will also be used to identify latent wheezing phenotypes, especially focusing on differences between infectious and non-infectious wheezing. Recruitment will occur at a single hospital in the Coastal Bend region with a modest sample size, which may limit generalizability. REGISTRATION: Clinical trial number: not applicable. Open Science Framework [ https://osf.io/tbg6y/overview?view_only=87309518c35b4d78a7bbe79d5fa70ceb ]. CI - (c) 2026. The Author(s). FAU - Warden, Donald E AU - Warden DE AD - College of Nursing and Health Sciences, Texas A&M University - Corpus Christi, Corpus Christi, USA. FAU - Meyers, Aidan AU - Meyers A AD - College of Nursing and Health Sciences, Texas A&M University - Corpus Christi, Corpus Christi, USA. FAU - Almekhlabi, Hiea AU - Almekhlabi H AD - College of Nursing and Health Sciences, Texas A&M University - Corpus Christi, Corpus Christi, USA. FAU - Kuchavaram, Manasa AU - Kuchavaram M AD - College of Nursing and Health Sciences, Texas A&M University - Corpus Christi, Corpus Christi, USA. FAU - Richmond, Erin AU - Richmond E AD - Global Institute for Hispanic Health, Corpus Christi, USA. FAU - Allison-Hoien, Mari AU - Allison-Hoien M AD - Global Institute for Hispanic Health, Corpus Christi, USA. FAU - Jin, Lei AU - Jin L AD - College of Science, Texas A&M University - Corpus Christi, Corpus Christi, USA. FAU - Johnson, Natalie AU - Johnson N AD - School of Public Health, Texas A&M University, College Station, USA. FAU - Roberts, Jon AU - Roberts J AD - Department of Pediatric Pulmonology, Driscoll Children's Hospital, Corpus Christi, USA. FAU - Melaram, Rajesh AU - Melaram R AUID- ORCID: 0000-0001-5223-5993 AD - College of Nursing and Health Sciences, Texas A&M University - Corpus Christi, Corpus Christi, USA. rajesh.melaram@tamucc.edu. LA - eng PT - Journal Article DEP - 20260623 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - 0 (Air Pollutants) SB - IM MH - Humans MH - *Asthma/epidemiology MH - Prospective Studies MH - *Environmental Exposure/adverse effects/analysis MH - Child MH - Male MH - Child, Preschool MH - Female MH - Air Pollutants/analysis/adverse effects MH - Texas/epidemiology MH - *Environmental Health MH - Respiratory Sounds MH - Infant MH - *Hispanic or Latino/statistics & numerical data MH - Research Design MH - Air Pollution/adverse effects PMC - PMC13540882 OTO - NOTNLM OT - Air pollutants OT - Asthma exacerbation OT - Children OT - Household OT - Wheezing COIS- Declarations. Ethics approval and consent to participate: This study adheres to the Declaration of Helsinki. Ethical approval was granted by the DCHIRB (FY2025-85). Written informed consent is obtained from parents/guardians. Study data are collected and managed using REDCap hosted at Texas A&M University - Corpus Christi. REDCap provides audit trails for tracking data changes and user activity. Furthermore, a data use and management protocol has been developed to secure data access and protect personal identifying information. REDCap study IDs are unique to patients, and the linkage between BREATHE-CC ID and DCH ID will be stored on a separate server accessible only to key study personnel. Patient addresses and date of birth will be anonymized by authorized personnel and transformed into calculated variables (age and geocoded address with a jitter). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/23 11:37 MHDA- 2026/09/03 05:37 PMCR- 2026/06/23 CRDT- 2026/06/23 01:07 PHST- 2026/04/25 00:00 [received] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/09/03 05:37 [medline] PHST- 2026/06/23 11:37 [pubmed] PHST- 2026/06/23 01:07 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - 10.1186/s12889-026-28265-5 [pii] AID - 28265 [pii] AID - 10.1186/s12889-026-28265-5 [doi] PST - epublish SO - BMC Public Health. 2026 Jun 23;26(1):2521. doi: 10.1186/s12889-026-28265-5. PMID- 42332628 OWN - NLM STAT- Publisher LR - 20260623 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) DP - 2026 Jun 23 TI - Urinary proteomic profiling identifies candidate biomarkers for pediatric MAFLD in comparison with obesity and healthy controls. LID - 10.1186/s12887-026-07070-4 [doi] AB - PURPOSE: This exploratory pilot study, employing a single-center and cross-sectional design, aimed to characterize urinary protein alterations associated with pediatric metabolic-associated fatty liver disease (MAFLD) and to identify preliminary candidate proteins associated with MAFLD status within a cohort of children with obesity. METHODS: In this single-center, cross-sectional observational study, urine samples were collected from 39 children and assigned to three groups: healthy controls (n = 10), simple obesity (n = 14), and obesity with MAFLD (diagnosed by ultrasonography, n = 15). Data-independent acquisition (DIA)-based quantitative proteomics was performed. After quality control, shared proteins across groups were analyzed by one-way ANOVA and trend clustering. Functional enrichment was conducted using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. Pearson correlation was used to examine associations between key proteins and clinical metabolic indicators. Exploratory discriminatory potential within this cohort was assessed using Receiver operating characteristic (ROC) curves. RESULTS: A total of 2,824 intersecting proteins were identified, and 49 showed significant differences among the three groups. Trend analysis and fold-change filtering (|log(2)FC| > 0.585) identified 19 core proteins with consistent expression gradients across the healthy, obese, and MAFLD groups. Among these, 6-phosphogluconolactonase (PGLS), dipeptidyl peptidase 7 (DPP7), and complement factor I (CFI) demonstrated notable correlations with liver function markers and glucose-lipid metabolic indices. ROC analysis indicated that PGLS provided the strongest discrimination. CONCLUSION: We performed urinary proteomic profiling to characterize metabolic alterations in pediatric MAFLD. Our analysis identified distinct protein signatures across the HC-OB-MAFLD spectrum, highlighting metabolic dysregulation, oxidative stress, and complement activation as primary features of disease progression. While PGLS, DPP7, and CFI emerged as potential biomarkers, PGLS demonstrated the greatest potential for distinguishing MAFLD from simple obesity in this specific cohort. Due to the small sample size (n = 39) and cross-sectional design, these results provide preliminary molecular insights that require large-scale, longitudinal validation to confirm their clinical utility. TRIAL REGISTRATION: International Traditional Medicine Clinical Trial Registry ITMCTR2025001222, December 31, 2024. Retrospectively registered. CI - (c) 2026. The Author(s). FAU - Zhang, Xiaohui AU - Zhang X AD - Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Zhu, Zhongyi AU - Zhu Z AD - Department of Traditional Chinese Medicine, Shenzhen Children's Hospital, Shenzhen, China. FAU - Zhou, Zhaoxin AU - Zhou Z AD - Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China. FAU - Liu, Chang AU - Liu C AD - Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Du, Lina AU - Du L AD - Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Guo, Ziyun AU - Guo Z AD - Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Pu, Guowei AU - Pu G AD - Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China. FAU - He, Qiang AU - He Q AD - Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. bch_hq@126.com. FAU - Yang, Yan AU - Yang Y AD - Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. yy2303@sina.com. LA - eng GR - No. 2024-2-2095/Capital's Funds for Health Improvement and Research/ PT - Journal Article DEP - 20260623 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM OTO - NOTNLM OT - Childhood obesity OT - Metabolic-associated fatty liver disease (MAFLD) OT - Noninvasive biomarkers OT - Pediatrics OT - Urinary proteomics COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Medical Ethics Committee of Beijing Children's Hospital, Capital Medical University (approval No. [2024]-Y-095-D). The study was registered at the International Traditional Medicine Clinical Trial Registry (ITMCTR2025001222) on December 31, 2024 (Retrospectively registered). Written informed consent was obtained from all participating children and their legal guardians prior to enrollment, in accordance with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/23 11:34 MHDA- 2026/06/23 11:34 CRDT- 2026/06/23 01:07 PHST- 2026/01/27 00:00 [received] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/06/23 11:34 [medline] PHST- 2026/06/23 11:34 [pubmed] PHST- 2026/06/23 01:07 [entrez] AID - 10.1186/s12887-026-07070-4 [pii] AID - 10.1186/s12887-026-07070-4 [doi] PST - aheadofprint SO - BMC Pediatr. 2026 Jun 23. doi: 10.1186/s12887-026-07070-4. PMID- 42331896 OWN - NLM STAT- Publisher LR - 20260622 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) DP - 2026 Jun 22 TI - Comprehensive behavioral and demographic correlates in myopia risk among Tibetan adolescents: a machine learning analysis using non‑cycloplegic refraction. LID - 10.1038/s41598-026-58744-z [doi] AB - Myopia is a global public health concern, especially among children and adolescents. This exploratory study aimed to develop a myopia risk prediction model for Tibetan adolescents using interpretable machine learning, while explicitly acknowledging the methodological limitations of non-cycloplegic refraction and self-reported data. We included 735 Tibetan adolescents. An XGBoost algorithm was used to build a binary classification model, with the SHAP method applied for feature interpretation. Data were split into 80% training and 20% test sets to analyze associations between behavioral, demographic factors, and myopia risk. Myopia was defined using non-cycloplegic autorefraction (uncorrected visual acuity < 5.0 [logMAR 0.0] and spherical equivalent /= 47 on WCS was associated with elevated psychological distress across all groups except for boys from lower socio-economic-status backgrounds. The present study is the first to apply confirmatory factor analysis to the WCS in adolescents. Future research needs to establish validity of the WCS as a screen in adolescents in terms of associations with ED psychopathology and behaviours. In addition, validation against diagnostic interview is crucial to establishing the WCS as a screening tool. CI - (c) 2026. The Author(s). FAU - Radunz, Marcela AU - Radunz M AUID- ORCID: 0000-0002-2858-0313 AD - Discipline of Psychology, Flinders University, GPO Box 2100, Adelaide, South Australia, 5001, Australia. marcela.radunz@flinders.edu.au. FAU - Jabs, Maya AU - Jabs M AUID- ORCID: 0009-0000-8369-1086 AD - Discipline of Psychology, Flinders University, GPO Box 2100, Adelaide, South Australia, 5001, Australia. FAU - King, Daniel L AU - King DL AUID- ORCID: 0000-0002-1762-2581 AD - Discipline of Psychology, Flinders University, GPO Box 2100, Adelaide, South Australia, 5001, Australia. FAU - Wade, Tracey D AU - Wade TD AUID- ORCID: 0000-0003-4402-770X AD - Discipline of Psychology, Flinders University, GPO Box 2100, Adelaide, South Australia, 5001, Australia. LA - eng PT - Journal Article DEP - 20260622 PL - Germany TA - Eur Child Adolesc Psychiatry JT - European child & adolescent psychiatry JID - 9212296 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - Factor Analysis, Statistical MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Psychometrics MH - Child MH - Sex Factors MH - Australia MH - *Psychiatric Status Rating Scales/standards MH - Surveys and Questionnaires MH - South Australia MH - Mass Screening MH - *Body Weight MH - Psychological Distress PMC - PMC13696600 OTO - NOTNLM OT - Adolescents OT - Eating disorders OT - Factor structure OT - Screening tool OT - Weight concerns COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/06/22 13:44 MHDA- 2026/10/25 17:31 PMCR- 2026/06/22 CRDT- 2026/06/22 11:13 PHST- 2025/05/07 00:00 [received] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/10/25 17:31 [medline] PHST- 2026/06/22 13:44 [pubmed] PHST- 2026/06/22 11:13 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.1007/s00787-026-03101-8 [pii] AID - 3101 [pii] AID - 10.1007/s00787-026-03101-8 [doi] PST - ppublish SO - Eur Child Adolesc Psychiatry. 2026 Oct;35(10):3313-3323. doi: 10.1007/s00787-026-03101-8. Epub 2026 Jun 22. PMID- 42328216 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260622 LR - 20260813 IS - 0974-7052 (Print) IS - 0975-1904 (Electronic) IS - 0974-7052 (Linking) VI - 19 IP - 3 DP - 2026 Mar TI - Association Between Junk Food Consumption and Behavioral Outcomes in 10-15-year-old Children: A Cross-sectional Questionnaire-based Study. PG - 318-323 LID - 10.5005/jp-journals-10005-3474 [doi] AB - BACKGROUND: Dietary habits and food consumption patterns have long been a focus of interest for both researchers and healthcare professionals. In recent years, growing awareness of the role of nutrition in overall well-being, along with a noticeable rise in diet-related health problems, has intensified this focus. Furthermore, increased concern is surfacing regarding the effect of junk food has on the behavior patterns among children; however, there is limited evidence. The present questionnaire study aims to investigate the association between junk food consumption and behavioral issues among 10-15-year-old children attending schools in and around Rajanagaram, Andhra Pradesh. METHODS: A cross-sectional study was conducted among 1,500 students using a validated dietary questionnaire and the Strengths and Difficulties Questionnaire (SDQ) adolescent self-report version. Junk food consumption (based on IAP guidelines) and behavioral categories were evaluated from the reported questionnaires, and the association between the two variables was analyzed statistically using Chi-square and Pearson correlation tests. RESULTS: Moderate junk food consumption was reported by 71.3% of children, with 11.8% reporting severe intake. SDQ revealed 81.6% had abnormal behavior scores, predominantly hyperactivity (54.78%) and conduct problems (67.02%). Although Pearson correlation was statistically nonsignificant (p = 0.963), a trend of increased behavioral issues with higher junk food intake was observed. CONCLUSION: A high prevalence of behavioral disturbances was seen among children with moderate to severe junk food consumption. Educational and policy-based interventions focusing on nutrition are urgently needed. HOW TO CITE THIS ARTICLE: Markapurapu BS, Balakrishnan V, Martha S, et al. Association Between Junk Food Consumption and Behavioral Outcomes in 10-15-year-old Children: A Cross-sectional Questionnaire-based Study. Int J Clin Pediatr Dent 2026;19(3):318-323. CI - Copyright (c) 2026; The Authors. FAU - Markapurapu, Baba S AU - Markapurapu BS AUID- ORCID: 0009-0000-0031-1202 AD - Department of Pediatric and Preventive Dentistry, Dr NTR University of Health Sciences, Vijayawada, Andhra Pradesh, India. FAU - Balakrishnan, Veena AU - Balakrishnan V AUID- ORCID: 0009-0009-1469-6559 AD - Department of Pedodontics and Preventive Dentistry, Lenora Institute of Dental Sciences, Rajamahendravaram, Andhra Pradesh, India. FAU - Martha, Satyam AU - Martha S AUID- ORCID: 0000-0003-4739-3000 AD - Department of Pedodontics and Preventive Dentistry, Lenora Institute of Dental Sciences, Rajamahendravaram, Andhra Pradesh, India. FAU - Maganti, Sri R AU - Maganti SR AD - Department of Pedodontics and Preventive Dentistry, Lenora Institute of Dental Sciences, Rajamahendravaram, Andhra Pradesh, India. FAU - Haritha, K AU - Haritha K AUID- ORCID: 0000-0003-3968-9987 AD - Department of Pedodontics and Preventive Dentistry, Lenora Institute of Dental Sciences, Rajamahendravaram, Andhra Pradesh, India. FAU - Yaramala, Harshitha AU - Yaramala H AUID- ORCID: 0009-0002-3172-2092 AD - Department of Pedodontics and Preventive Dentistry, Lenora Institute of Dental Sciences, Rajamahendravaram, Andhra Pradesh, India. LA - eng PT - Journal Article DEP - 20260302 PL - India TA - Int J Clin Pediatr Dent JT - International journal of clinical pediatric dentistry JID - 101585405 PMC - PMC13280508 OTO - NOTNLM OT - Adolescent behavior OT - Cross-sectional study OT - Junk food OT - Schoolchildren OT - Strengths and Difficulties Questionnaire COIS- Source of support: Nil Conflict of interest: NoneConflict of interest: None EDAT- 2026/06/22 13:43 MHDA- 2026/06/22 13:44 PMCR- 2026/04/01 CRDT- 2026/06/22 07:23 PHST- 2025/06/21 00:00 [received] PHST- 2025/07/21 00:00 [accepted] PHST- 2026/06/22 13:44 [medline] PHST- 2026/06/22 13:43 [pubmed] PHST- 2026/06/22 07:23 [entrez] PHST- 2026/04/01 00:00 [pmc-release] AID - 10.5005/jp-journals-10005-3474 [doi] PST - ppublish SO - Int J Clin Pediatr Dent. 2026 Mar;19(3):318-323. doi: 10.5005/jp-journals-10005-3474. Epub 2026 Mar 2. PMID- 42327482 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260622 LR - 20260813 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 6 DP - 2026 Jun TI - Shear Wave Elastography in Children: Normative Values and the Impact of Healthy Habits in a Cross-Sectional Study. PG - e72653 LID - 10.1002/hsr2.72653 [doi] LID - e72653 AB - OBJECTIVES: Biomechanical properties of the musculoskeletal system are important to understand muscle function, but they are difficult to assess noninvasively. Shear wave elastography (SWE) allows objective quantification of muscle elasticity. However, normative data and the influence of lifestyle habits on muscle elasticity in children remain unclear, particularly across multiple upper and lower limb muscles and in relation to modifiable healthy behaviors. The main objective was to assess muscle elasticity at rest and during maximum passive stretching (MPS) in children using SWE, and to address existing gaps by evaluating multiple muscles from both limbs, as well as to evaluate the influence of lifestyle factors, with particular attention to healthy habits. DESIGN AND METHODS: SWE was used to measure the elasticity of the biceps brachii, pronator teres, adductor longus, lateral gastrocnemius, and soleus in 44 typically developing children (mean age 8.9 years; range 3-14 years; 27 females). Measurements were taken at rest and MPS. Data included anthropometry, physical fitness, Mediterranean diet adherence, moderate-to-vigorous physical activity (MVPA), and sleep duration, allowing the exploration of lifestyle-related determinants of muscle elasticity. RESULTS: Reliability estimates exceeded 0.91, indicating excellent consistency. SWE values increased with higher Mediterranean adherence during MPS in all muscles, while at rest, an inverse relationship appeared in biceps and pronator teres. Sleep time was negatively associated with SWE at rest and positively adductor longus during MPS. MVPA showed some associations without consistent patterns. CONCLUSIONS: SWE is a reliable and objective technique to evaluate muscle elasticity in typically developing children. By providing multi-muscle reference data from both upper and lower limbs and demonstrating associations with diet and sleep, this study extends current pediatric SWE literature beyond feasibility and reliability. These findings suggest that SWE could help quantify the physiological impact of healthy habits on muscle properties during childhood. CI - (c) 2026 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Casellas-Vidal, Dolors AU - Casellas-Vidal D AUID- ORCID: 0000-0001-9560-6758 AD - Servei de Pediatria Hospital Universitari Doctor Josep Trueta Girona Spain. AD - Neurodevelopmental Group [Girona Biomedical Research Institute]-IDIBGI Institute of Health Assistance (IAS), Parc Hospitalari Marti i Julia Girona Spain. FAU - Font-Llado, Raquel AU - Font-Llado R AD - University School of Health and Sport (EUSES) University of Girona Girona Spain. AD - Research Group of Culture and Education, Institute of Educational Research University of Girona Girona Spain. FAU - Osiniri, Ines AU - Osiniri I AD - Servei de Pediatria, Clinica Bofill Girona Spain. FAU - Camos-Carreras, Maria AU - Camos-Carreras M AD - Servei de Pediatria Hospital Universitari Doctor Josep Trueta Girona Spain. AD - Neurodevelopmental Group [Girona Biomedical Research Institute]-IDIBGI Institute of Health Assistance (IAS), Parc Hospitalari Marti i Julia Girona Spain. FAU - Ruiz-Eizmendi, Aintzane AU - Ruiz-Eizmendi A AD - Servei de Rehabilitacio Hospital Universitari Doctor Josep Trueta Girona Spain. FAU - Serrano-Ferrer, Juan AU - Serrano-Ferrer J AUID- ORCID: 0009-0001-6080-2772 AD - University School of Health and Sport (EUSES) University of Girona Girona Spain. FAU - Casellas, Joaquim AU - Casellas J AD - Departament de Ciencia Animal i dels Aliments Universitat Autonoma de Barcelona Bellaterra Spain. FAU - Lopez-Bermejo, Abel AU - Lopez-Bermejo A AD - Servei de Pediatria Hospital Universitari Doctor Josep Trueta Girona Spain. AD - Pediatric Endocrinology Group Girona Biomedical Research Institute (IDIBGI) Salt Spain. FAU - Prats-Puig, Anna AU - Prats-Puig A AUID- ORCID: 0000-0002-5253-3808 AD - Research Group of Health and Health Care, Nursing Department University of Girona Girona Spain. LA - eng PT - Journal Article DEP - 20260619 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC13281414 OTO - NOTNLM OT - children OT - healthy habits OT - lifestyle factors OT - muscle elasticity OT - shear wave elastography COIS- The authors declare no conflicts of interest. EDAT- 2026/06/22 13:42 MHDA- 2026/06/22 13:43 PMCR- 2026/06/19 CRDT- 2026/06/22 07:15 PHST- 2025/11/13 00:00 [received] PHST- 2026/05/28 00:00 [revised] PHST- 2026/06/04 00:00 [accepted] PHST- 2026/06/22 13:43 [medline] PHST- 2026/06/22 13:42 [pubmed] PHST- 2026/06/22 07:15 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - HSR272653 [pii] AID - 10.1002/hsr2.72653 [doi] PST - epublish SO - Health Sci Rep. 2026 Jun 19;9(6):e72653. doi: 10.1002/hsr2.72653. eCollection 2026 Jun. PMID- 42327477 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260622 LR - 20260813 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 6 DP - 2026 Jun TI - Psychometric Properties of the Participation Motivation Questionnaire Among Hungarian Female Students. PG - e72696 LID - 10.1002/hsr2.72696 [doi] LID - e72696 AB - BACKGROUND AND AIM: Based on the self-determination theory (SDT), this study primarily aimed to examine the reliability and validity of the Hungarian version of the Participation Motivation Questionnaire (PMQ) among 13-15-year-old female students, and secondarily to describe their motivational profiles and the relationships between motives and physical activity level. METHODS: Three hundred twenty-five female students (mean age = 14.07; SD = 0.87) from nine different schools-wealthy, moderate, and lower income- were randomly sampled from Budapest and its suburbs. Exploratory Factor Analysis was used with the maximum likelihood extraction method and varimax rotation. To establish construct validity, Confirmatory Factor Analysis was conducted. Internal consistency of the questionnaire and its subscales was assessed using Cronbach's alpha. RESULTS: A 27‑item, six-factor solution emerged, partially differing from the original eight-factor structure, and showed acceptable internal consistency (alpha = 0.73-0.84). Associations between motivational factors and sociodemographic characteristics (age, socioeconomic status, urban-rural residence) and physical activity level revealed significant effects of sociodemographic factors on motivation. Fitness emerged as the only motivational factor showing a strong, direct relationship with adolescents' physical activity level. In terms of SDT, intrinsic‑oriented, health‑ and mastery‑related reasons appeared more important than ego‑related and extrinsic reasons for encouraging female students to be physically active. Given the cross-sectional design and the urban-skewed sample, these subgroup findings should be interpreted with caution and considered as a means of generating hypotheses. CONCLUSION: In conclusion, the Hungarian version of the PMQ appears suitable for assessing participation motives among female students in school and sport-related settings and may support educators and practitioners in better understanding motivational patterns when planning and evaluating physical activity programmes. CI - (c) 2026 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Ghazvini, Narges AU - Ghazvini N AUID- ORCID: 0000-0001-7335-3948 AD - Doctoral School, Hungarian University of Sports Science Budapest Hungary. AD - Department of Pedagogy Hungarian University of Sports Science Budapest Hungary. FAU - Hamar, Pal AU - Hamar P AUID- ORCID: 0009-0008-8651-3013 AD - Department of Pedagogy Hungarian University of Sports Science Budapest Hungary. AD - Sapientia Hungarian University of Transylvania Sf. Gheorghe Romania. AD - Ludovika University of Public Service Budapest Hungary. FAU - Takacs, Johanna AU - Takacs J AUID- ORCID: 0000-0002-8709-8826 AD - Department of Social Sciences Semmelweis University Budapest Hungary. FAU - Petridis, Leonidas AU - Petridis L AUID- ORCID: 0000-0002-8534-7550 AD - Research Center for Sport Physiology Hungarian University of Sport Science Budapest Hungary. FAU - Soos, Istvan AU - Soos I AUID- ORCID: 0000-0002-5511-9477 AD - Department of Pedagogy Hungarian University of Sports Science Budapest Hungary. LA - eng PT - Journal Article DEP - 20260620 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC13282752 OTO - NOTNLM OT - Hungarian female students OT - participation motivation questionnaire OT - physical activity OT - self-determination theory OT - sociodemographic factors COIS- The authors declare no conflicts of interest. EDAT- 2026/06/22 13:44 MHDA- 2026/06/22 13:45 PMCR- 2026/06/20 CRDT- 2026/06/22 07:15 PHST- 2025/11/18 00:00 [received] PHST- 2026/03/09 00:00 [revised] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/06/22 13:45 [medline] PHST- 2026/06/22 13:44 [pubmed] PHST- 2026/06/22 07:15 [entrez] PHST- 2026/06/20 00:00 [pmc-release] AID - HSR272696 [pii] AID - 10.1002/hsr2.72696 [doi] PST - epublish SO - Health Sci Rep. 2026 Jun 20;9(6):e72696. doi: 10.1002/hsr2.72696. eCollection 2026 Jun. PMID- 42325730 OWN - NLM STAT- MEDLINE DCOM- 20260622 LR - 20260813 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 15 DP - 2026 TI - Dietary assessment tools for children and adolescents in Latin America: a scoping review. PG - e46 LID - 10.1017/jns.2026.10116 [doi] LID - e46 AB - Accurately assessing dietary intake in children and adolescents is essential for understanding dietary patterns and informing public health strategies. In Latin America, rapid nutrition transitions and increasing childhood obesity highlight the need for culturally appropriate, validated dietary assessment tools (DATs). However, methodological challenges and limited regional data hinder effective dietary surveillance. This scoping review identified and characterised DATs used among children and adolescents (5-18 years) in Latin America, examining tool types, features, validation and regional coverage. Following Joanna Briggs Institute and PRISMA-ScR guidelines, comprehensive searches were conducted in EMBASE, Web of Science, PubMed, and LILACS (April 2024) in English, Spanish, and Portuguese. Eligible studies included original research developing, validating, or applying DATs in Latin American populations. Of 13,946 records screened, 105 reports met the inclusion criteria. Brazil and Mexico contributed the most studies, while six countries (Paraguay, El Salvador, Nicaragua, Panama, Honduras, and Belize) had none. Forty-three DATs were identified, 77% of which were food frequency questionnaires (FFQs). Half targeted adolescents, 39% children, and 11% both groups. Most were interviewer-administered (58%) and applied in person (49%), with only 19% conducted online, reflecting regional digital limitations. Validation was reported for 70% of tools, primarily against 24 HR. The DAT landscape in Latin America remains dominated by FFQs and traditional administration methods, with limited use of digital platforms. Developing age-appropriate, validated and culturally adapted digital DATs is essential to strengthen dietary surveillance and guide effective nutrition policies across the region. CI - (c) The Author(s) 2026. FAU - Vidal, Milca AU - Vidal M AUID- ORCID: 0009-0002-9328-8981 AD - Food Science and Nutrition, University of Leeds Faculty of Environment, UK. ROR: https://ror.org/024mrxd33 FAU - Iqbal, Muhammed AU - Iqbal M AD - Food Science and Nutrition, University of Leeds Faculty of Environment, UK. ROR: https://ror.org/024mrxd33 AD - Clinical nutrition, Politeknik Negeri Jember, Indonesia. FAU - Cade, Janet AU - Cade J AD - Nutrition Epidemiology Group, University of Leeds, UK. FAU - Nykjaer, Camilla AU - Nykjaer C AD - School of Biomedical Sciences, University of Leeds Faculty of Biological Sciences, UK. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260617 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 SB - IM MH - Humans MH - Child MH - Adolescent MH - Latin America MH - *Nutrition Assessment MH - Child, Preschool MH - *Diet MH - *Diet Surveys/methods PMC - PMC13279971 OTO - NOTNLM OT - Adolescents OT - Children OT - Dietary assessment tool OT - Latin America OT - Scoping Review COIS- The author(s) declare none. EDAT- 2026/06/22 13:42 MHDA- 2026/06/22 19:00 PMCR- 2026/06/17 CRDT- 2026/06/22 06:59 PHST- 2025/11/10 00:00 [received] PHST- 2026/05/11 00:00 [revised] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/06/22 19:00 [medline] PHST- 2026/06/22 13:42 [pubmed] PHST- 2026/06/22 06:59 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - S2048679026101165 [pii] AID - 10.1017/jns.2026.10116 [doi] PST - epublish SO - J Nutr Sci. 2026 Jun 17;15:e46. doi: 10.1017/jns.2026.10116. eCollection 2026. PMID- 42325327 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260622 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Family sports environment and emotional regulation in Chinese adolescents: the mediating roles of sports lifestyle and parent-child interaction. PG - 1812203 LID - 10.3389/fpsyg.2026.1812203 [doi] LID - 1812203 AB - Against the backdrop of increasingly prominent mental health issues among adolescents, insufficient development of the family sports environment, a key external factor associated with emotional regulation, has emerged as a critical but often overlooked determinant of psychological stability and resilience among Chinese youth. In particular, the absence of an active sports lifestyle and structured parent-child interaction patterns may be associated with impaired emotional regulation processes, highlighting the need to examine the associational pathways. OBJECTIVE: This study aimed to investigate the association between the family sports environment and emotional regulation abilities among Chinese adolescents and to explore the serial indirect associations of sports; lifestyle and parent-child relationship within a theoretically informed mediation model. METHODS: A cluster sampling survey was conducted among 750 Chinese adolescents. Data were collected using the Family Sports Environment Scale, the Adolescent Emotional Regulation Scale, the Sports Lifestyle Scale, and the Parent-Child Relationship Scale. All variables were measured at a single time point using self-report questionnaires. RESULTS: (1) No statistically significant differences were observed across gender or age in family sports environment, emotional regulation, sports lifestyle, or parent-child relationship (p > 0.05); (2) The family sports environment was significantly and positively associated with emotional regulation (r = 0.698, p < 0.001). Regression analyses indicated that the total effect of family sports environment on emotional regulation was significant (unstandardized coefficient, B = 0.292; t = 26.811, p < 0.001). while the direct effect also remained significant (standardized coefficient,beta = 0.207; t = 3.829, p < 0.001). In addition, the family sports environment was significantly associated with variations in sports lifestyle (B = 1.957, t = 37.969, p < 0.001) and parent-child relationship (B = 0.292, t = 8.445, p < 0.001). Sports lifestyle was significantly associated with variations in parent-child relationship (beta = 0.226, t = 15.931, p < 0.001) and emotional regulation (beta = 0.203, t = 8.400, p < 0.001). Moreover, the parent-child relationship was significantly associated with variations in emotional regulation (beta = 0.524, t = 9.175, p < 0.001); (3) Sports lifestyle and parent-child relationship both demonstrated significant mediating associations in the relationship between family sports environment and adolescent emotional regulation, consistent with a serial mediation model of associations. CONCLUSION: The family sports environment was significantly associated with healthier sports lifestyles among Chinese adolescents and more positive parent-child relationships, and was also indirectly associated with emotional regulation abilities through the sequential mediating effects of these two factors. Sports lifestyles and parent-child relationships function as key intermediary pathways linking the family sports environment to adolescents' emotional regulation, thereby providing a theoretically informed explanation of the observed associative pathways. From a practical perspective, these findings suggest that optimizing the family sports environment, encouraging parent-child engagement in physical activities, and fostering regular physical activity habits among adolescents may be supportive contextual factors for improving emotional regulation and supporting mental health development. Such strategies may also provide valuable implications for family-based sports guidance and adolescent mental health support practices. However, this study is subject to limitations related to sample representativeness and cross-sectional research design. Future research is encouraged to employ longitudinal designs and incorporate more comprehensive family-context variables to further examine and validate these associations. CI - Copyright (c) 2026 Zhou, Liu and Xiang. FAU - Zhou, Zhixing AU - Zhou Z AD - School of Physical Education and Health, Zhaoqing University, Zhaoqing, China. FAU - Liu, Weijian AU - Liu W AD - School of Physical Education and Health, Zhaoqing University, Zhaoqing, China. FAU - Xiang, Jun AU - Xiang J AD - School of Physical Education and Health, Zhaoqing University, Zhaoqing, China. LA - eng PT - Journal Article DEP - 20260604 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13275267 OTO - NOTNLM OT - adolescents OT - emotional regulation OT - family sports environment OT - mediating effect OT - mental health OT - parent-child relationship OT - psychological resilience OT - sports lifestyle COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/22 13:42 MHDA- 2026/06/22 13:43 PMCR- 2026/06/04 CRDT- 2026/06/22 06:56 PHST- 2026/02/16 00:00 [received] PHST- 2026/04/27 00:00 [revised] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/06/22 13:43 [medline] PHST- 2026/06/22 13:42 [pubmed] PHST- 2026/06/22 06:56 [entrez] PHST- 2026/06/04 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1812203 [doi] PST - epublish SO - Front Psychol. 2026 Jun 4;17:1812203. doi: 10.3389/fpsyg.2026.1812203. eCollection 2026. PMID- 42324999 OWN - NLM STAT- MEDLINE DCOM- 20260817 LR - 20260922 IS - 1524-4539 (Electronic) IS - 0009-7322 (Print) IS - 0009-7322 (Linking) VI - 154 IP - 7 DP - 2026 Aug 18 TI - Consumption of Fructose-Containing Food and Beverage Sources in Childhood Through to Adulthood and Risk of Hypertension: A Prospective Cohort Study. PG - 612-623 LID - 10.1161/CIRCULATIONAHA.125.077666 [doi] AB - BACKGROUND: High intakes of fructose-containing sugars among children and adolescents is implicated in obesity and related comorbidities, including hypertension. However, sugar-sweetened beverages (SSBs), fruit juices, and whole fruit have different nutritional profiles and matrices, which may confer different effects on blood pressure. METHODS: GUTS (Growing Up Today Study) is a longitudinal cohort of 25 749 individuals (55% female) drawn from 2 enrollment waves, GUTS 1 (n=16 875; baseline 1996) and GUTS II (n=10 918; baseline 2004), followed up prospectively through 2021 (mean age at enrollment, 12 years; mean age at end of follow-up, 36 years). Participants provided updated information on lifestyle, health status, and habitual diet through validated food frequency questionnaires every 1 to 4 years. We conducted multivariable adjusted Cox proportional hazards regression models to estimate the associations of total fructose and SSB, fruit juice, and whole fruit intake (cumulative averages) with incident hypertension (hazard ratios [HRs] and 95% CIs), adjusting for major diet and lifestyle factors. We also modeled substitutions of SSBs or fruit juice with whole fruit, milk, and water. RESULTS: During up to 25 years of follow-up, 1625 participants (6.3%) reported a hypertension diagnosis. Total fructose intake was not associated with incident hypertension (highest versus lowest quintile HR, 1.07 [95% CI, 0.92, 1.25]; P(trend)<0.001). However, participants with the highest intake of SSBs (>/=2 servings/d versus <3 servings/week) and fruit juice (>/=1.5 servings/d versus <1 serving/wk) had a higher risk of hypertension (HR, 1.52 [95% CI, 1.27, 1.83]; P(trend)<0.001 and HR, 1.35 [95% CI, 1.06, 1.71]; P(trend)=0.018, respectively). In contrast, whole fruit was not associated with hypertension (highest versus lowest category HR, 0.79 [95% CI, 0.59, 1.05]; P(trend)=0.08). Replacing 1 serving/d of SSB with milk, water, or whole fruit was associated with a 13% (95% CI, 5%, 20%), 9% (95% CI, 3%, 15%), and 22% (95% CI, 11%, 31%) lower risk of hypertension, respectively. In addition, replacing fruit juice with whole fruit was associated with a 19% (95% CI, 3%, 32%) lower risk of hypertension. CONCLUSIONS: SSB and fruit juice intakes were positively associated with a higher risk of hypertension independently of overall diet quality, physical activity, and other factors. Our findings support public health guidelines to limit the overconsumption of SSBs and fruit juice starting in childhood to protect against the development of hypertension. FAU - Nguyen, Michelle AU - Nguyen M AD - Department of Nutritional Sciences, Temerty Faculty of Medicine (M.N., A.J.H., C.S.B., J.L.S., V.S.M.). FAU - AlEssa, Hala B AU - AlEssa HB AD - Department of Nutrition (H.B.A., A.J.G., D.K.T., J.E.C., W.C.W., F.B.H., V.S.M.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Public Health Practice, College of Public Health, Kuwait University, Kuwait City (H.B.A.). FAU - Glenn, Andrea J AU - Glenn AJ AD - Department of Nutrition (H.B.A., A.J.G., D.K.T., J.E.C., W.C.W., F.B.H., V.S.M.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Nutrition and Food Studies, New York University, New York City (A.J.G.). FAU - Tobias, Deirdre K AU - Tobias DK AUID- ORCID: 0000-0003-0020-9552 AD - Department of Nutrition (H.B.A., A.J.G., D.K.T., J.E.C., W.C.W., F.B.H., V.S.M.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Medicine, Division of Preventive Medicine (D.K.T.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA. FAU - Chavarro, Jorge E AU - Chavarro JE AUID- ORCID: 0000-0002-4436-9630 AD - Department of Nutrition (H.B.A., A.J.G., D.K.T., J.E.C., W.C.W., F.B.H., V.S.M.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Epidemiology (J.E.C., W.C.W., F.B.H.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Medicine, Channing Division of Network Medicine (J.E.C., F.B.H.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA. FAU - Willett, Walter C AU - Willett WC AUID- ORCID: 0000-0003-1458-7597 AD - Department of Nutrition (H.B.A., A.J.G., D.K.T., J.E.C., W.C.W., F.B.H., V.S.M.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Epidemiology (J.E.C., W.C.W., F.B.H.), Harvard T.H. Chan School of Public Health, Boston, MA. FAU - Hu, Frank B AU - Hu FB AUID- ORCID: 0000-0002-8233-6274 AD - Department of Nutrition (H.B.A., A.J.G., D.K.T., J.E.C., W.C.W., F.B.H., V.S.M.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Epidemiology (J.E.C., W.C.W., F.B.H.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Medicine, Channing Division of Network Medicine (J.E.C., F.B.H.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA. FAU - Hanley, Anthony J AU - Hanley AJ AD - Department of Nutritional Sciences, Temerty Faculty of Medicine (M.N., A.J.H., C.S.B., J.L.S., V.S.M.). AD - Division of Endocrinology (A.J.H.), University of Toronto, ON Canada. AD - Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada (A.J.H.). FAU - Birken, Catherine S AU - Birken CS AUID- ORCID: 0000-0003-0308-8645 AD - Department of Nutritional Sciences, Temerty Faculty of Medicine (M.N., A.J.H., C.S.B., J.L.S., V.S.M.). AD - Department of Paediatrics (C.S.B.), University of Toronto, ON Canada. AD - Department of Medicine, Temerty Faculty of Medicine (C.S.B., J.L.S.), University of Toronto, ON Canada. AD - Child Health Evaluative Sciences, SickKids Research Institute, Toronto, ON, Canada (C.S.B.). FAU - Sievenpiper, John L AU - Sievenpiper JL AUID- ORCID: 0000-0002-3270-5772 AD - Department of Nutritional Sciences, Temerty Faculty of Medicine (M.N., A.J.H., C.S.B., J.L.S., V.S.M.). AD - Department of Medicine, Temerty Faculty of Medicine (C.S.B., J.L.S.), University of Toronto, ON Canada. AD - Toronto 3D Knowledge Synthesis & Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, Division of Endocrinology & Metabolism, and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada (J.L.S.). FAU - Malik, Vasanti S AU - Malik VS AD - Department of Nutritional Sciences, Temerty Faculty of Medicine (M.N., A.J.H., C.S.B., J.L.S., V.S.M.). AD - Department of Nutrition (H.B.A., A.J.G., D.K.T., J.E.C., W.C.W., F.B.H., V.S.M.), Harvard T.H. Chan School of Public Health, Boston, MA. LA - eng GR - U01 HL145386/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20260622 PL - United States TA - Circulation JT - Circulation JID - 0147763 RN - 30237-26-4 (Fructose) SB - IM MH - Humans MH - Female MH - *Fructose/adverse effects/administration & dosage MH - *Hypertension/epidemiology/diagnosis/etiology MH - Child MH - Prospective Studies MH - Male MH - *Sugar-Sweetened Beverages/adverse effects MH - Risk Factors MH - Adolescent MH - *Fruit and Vegetable Juices/adverse effects MH - Adult MH - *Beverages/adverse effects MH - Longitudinal Studies MH - Young Adult MH - Fruit MH - Incidence PMC - PMC13288772 MID - NIHMS2176243 OTO - NOTNLM OT - fructose OT - fruit OT - fruit and vegetable juices OT - hypertension OT - sugar-sweetened beverages COIS- Dr AlEssa is supported by the 2017 Faculty Research grant at the Middle East Initiative, Harvard Kennedy School by the Kuwait Foundation for the Advancement of Sciences, and by the Cardiovascular Health Research Grant 2023 by the Kuwait Heart Foundation. Dr Tobias is funded by the National Institutes of Health/National Institute for National Institute of Diabetes and Digestive and Kidney Diseases for related research. Dr Glenn has received travel support and/or honoraria from the Lawson Centre Nutrition Digital Series (University of Toronto), the Good Food Institute, Vinasoy, and the British Nutrition Society. Dr Hanley has received research grants from the Canadian Institutes of Health Research, Diabetes Canada, the Canadian Foundation for Innovation, the Canada Research Chairs Program, the Canadian Foundation for Innovation, and Dairy Farmers of Canada. Dr Sievenpiper has received research support from the Canadian Foundation for Innovation, Ontario Research Fund, Province of Ontario Ministry of Research and Innovation and Science, Canadian Institutes of Health Research, Diabetes Canada, American Society for Nutrition, National Honey Board (US Department of Agriculture honey "Checkoff" program), Institute for the Advancement of Food and Nutrition Sciences, Pulse Canada, Quaker Oats Center of Excellence, INC International Nut and Dried Fruit Council Foundation, The United Soybean Board (US Department of Agriculture soy "Checkoff" program), Protein Industries Canada (a government of Canada Global Innovation Cluster), Almond Board of California, European Fruit Juice Association, The Tate and Lyle Nutritional Research Fund at the University of Toronto, The Glycemic Control and Cardiovascular Disease in Type 2 Diabetes Fund at the University of Toronto (a fund established by the Alberta Pulse Growers), The Plant Protein Fund at the University of Toronto (a fund that has received contributions from IFF among other donors), The Plant Milk Fund at the University of Toronto (a fund established by the Karuna Foundation through Vegan Grants), and The Nutrition Trialists Network Fund at the University of Toronto (a fund established by donations from the Calorie Control Council, Physicians Committee for Responsible Medicine, and Login5 Foundation). He has received food donations to support randomized controlled trials from the Almond Board of California, California Walnut Commission, Danone, Nutrartis, Soylent, and Dairy Farmers of Canada. He has received travel support, speaker fees, and/or honoraria from FoodMinds LLC, Nestle, Abbott, General Mills, Nutrition Communications, International Food Information Council, Arab Beverage Association, International Sweeteners Association, Calorie Control Council, Phynova, International Stevia Council, Mantra Pharma Inc, Chinese Institute of Food Science and Technology, and Collaborative CME and Research Network. He has or has had ad hoc consulting arrangements with Almond Board of California, Perkins Coie LLP, Tate & Lyle, Ingredion, and Brightseed. He is on the Clinical Practice Guidelines Expert Committees of Diabetes Canada, European Association for the Study of Diabetes, Canadian Cardiovascular Society, and Obesity Canada/Canadian Association of Bariatric Physicians and Surgeons. He serves as an unpaid member of the Board of Trustees of the Institute for the Advancement of Food and Nutrition Sciences. He is a director at large of the Canadian Nutrition Society, founding member of the International Carbohydrate Quality Consortium, Executive Board member of the Diabetes and Nutrition Study Group of the European Association for the Study of Diabetes, and director of the Toronto 3D Knowledge Synthesis and Clinical Trials foundation. His spouse is a former employee of Nestle Health Science and AB InBev. Dr Malik has received funding from the Canada Research Chairs Program; Connaught New Researcher Award, University of Toronto; The Joannah & Brian Lawson Centre for Child Nutrition, University of Toronto; Temerty Faculty of Medicine Pathway Grant, University of Toronto; Canada Foundation for Innovation; Ontario Research Fund, Canadian Institutes of Health Research, National Institutes of Health, and has served as a consultant for the City and County of San Francisco for litigation related to health warning labels on SSBs and on the Robert Wood Johnson Healthy Eating Research Advisory Committee for child beverage guidance. Dr Birken received funding from Canadian Institutes of Health Research, Heart & Stroke Foundation of Canada, Physician Services Inc, The Edwin S.H. Leong Centre for Healthy Children, University of Toronto and Hospital for Sick Children, the Centre for Addiction and Mental Health, Joannah & Brian Lawson Centre for Child Nutrition, University of Toronto, and a Walmart Canada Regional Community Grant, administered through SickKids Foundation. The other authors report no conflicts. EDAT- 2026/06/22 06:45 MHDA- 2026/08/17 17:45 PMCR- 2026/06/24 CRDT- 2026/06/22 05:03 PHST- 2026/08/17 17:45 [medline] PHST- 2026/06/22 06:45 [pubmed] PHST- 2026/06/22 05:03 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.1161/CIRCULATIONAHA.125.077666 [doi] PST - ppublish SO - Circulation. 2026 Aug 18;154(7):612-623. doi: 10.1161/CIRCULATIONAHA.125.077666. Epub 2026 Jun 22. PMID- 42324958 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260911 IS - 1536-4801 (Electronic) IS - 0277-2116 (Print) IS - 0277-2116 (Linking) VI - 83 IP - 3 DP - 2026 Sep TI - Development and validation of the new French ORALQUEST scale for evaluating feeding difficulties in young children. PG - 528-535 LID - 10.1002/jpn3.70491 [doi] AB - OBJECTIVE: Feeding difficulties are common in children with and without somatic conditions. Our objective was to develop a parent-report questionnaire (ORALQUEST) designed to be administered by a professional and to assess feeding difficulties in children aged 9 months to 6 years. METHODS: The questionnaire explores four domains: eating behavior, oral skills, tactile and oral sensitivity, and family environment. A validation study was done in 338 children seen for feeding difficulties (n = 74) or receiving follow-up for conditions at risk for feeding difficulties (n = 264). We assessed the validity and reliability of the tool and we conducted a receiver operating characteristic (ROC) analysis to determine the best total-score cutoff. RESULTS: The final version of the ORALQUEST has 40 items and produces a total score and four sub-scores. Structural validity, internal consistency, and reliability were excellent; convergent validity was good to acceptable but was challenging to assess given the absence of similar tools for comparisons. The optimal total-score cutoff was 27. Among children seen for feeding difficulties, 85% had a total score >/= 27. Total scores above the cutoff were less common than expected in children with chronic conditions (esophageal atresia, 39%; autism spectrum disorder, 42%; complex congenital heart disease, 29%; Robin sequence, 31%; and cleft palate, 18%). CONCLUSION: ORALQUEST for assessing feeding difficulties in young children demonstrated good psychometric properties in children with and without somatic conditions. The investigation by ORALQUEST of four domains may help to determine the best management strategy. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT04133038 (Clinicaltrials.gov) https://clinicaltrials.gov/study/NCT04133038. CI - (c) 2026 The Author(s). Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Thouvenin, Beatrice AU - Thouvenin B AD - General Paediatric Unit, Necker University Hospital, Paris, France. FAU - Ould-Ammar, Redha AU - Ould-Ammar R AD - Unit of Clinical Research, AP-HP, University Necker Hospital, Paris, France. FAU - Ouss, Lisa AU - Ouss L AD - Child Psychiatry Unit, Necker University Hospital, Paris, France. FAU - Gavelle, Pascale AU - Gavelle P AD - Maxillo Facial Surgery Unit, Necker University Hospital, Paris, France. FAU - Disnan, Giulia AU - Disnan G AD - Paediatric Surgery, Necker University Hospital, Paris, France. FAU - Royer, Aurelie AU - Royer A AD - General Paediatric Unit, Necker University Hospital, Paris, France. AD - Reference Centre for Rare Disease <>, Necker University Hospital, Paris, France. FAU - Vegas, Nancy AU - Vegas N AD - General Paediatric Unit, Necker University Hospital, Paris, France. AD - Reference Centre for Rare Disease <>, Necker University Hospital, Paris, France. AD - Paris Cite University, Paris, France. FAU - Fraysseix, Catherine du AU - Fraysseix CD AD - General Paediatric Unit, Necker University Hospital, Paris, France. FAU - Adnot, Pauline AU - Adnot P AD - General Paediatric Unit, Necker University Hospital, Paris, France. AD - Reference Centre for Rare Disease <>, Necker University Hospital, Paris, France. FAU - Barbieri, Valeria AU - Barbieri V AD - General Paediatric Unit, Necker University Hospital, Paris, France. FAU - Hassler, Christine AU - Hassler C AD - CESP Centre of Epidemiology and Population Health, INSERM, Villejuif, France. FAU - Elie, Caroline AU - Elie C AD - Unit of Clinical Research, AP-HP, University Necker Hospital, Paris, France. AD - Universite Paris Cite, Inserm, Pharmacologie et Evaluations Des Therapeutiques Chez L'enfant Et La Femme Enceinte, Paris, France. FAU - Barry, Caroline AU - Barry C AD - CESP Centre of Epidemiology and Population Health, INSERM, Villejuif, France. FAU - Abadie, Veronique AU - Abadie V AUID- ORCID: 0000-0002-3525-1921 AD - General Paediatric Unit, Necker University Hospital, Paris, France. AD - Reference Centre for Rare Disease <>, Necker University Hospital, Paris, France. AD - Paris Cite University, Paris, France. AD - CESP Centre of Epidemiology and Population Health, INSERM, Villejuif, France. LA - eng SI - ClinicalTrials.gov/NCT04133038 GR - Assistance Publique - Hopitaux de Paris/ PT - Journal Article PT - Observational Study PT - Validation Study DEP - 20260622 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - *Feeding and Eating Disorders of Childhood/diagnosis/psychology MH - *Feeding Behavior/psychology MH - Parents MH - Psychometrics MH - Reproducibility of Results MH - ROC Curve MH - Surveys and Questionnaires/standards PMC - PMC13539697 OTO - NOTNLM OT - assessment OT - pediatric nutrition OT - psychometric qualities COIS- The authors declare no conflicts of interest. EDAT- 2026/06/22 06:46 MHDA- 2026/09/03 17:36 PMCR- 2026/09/03 CRDT- 2026/06/22 04:23 PHST- 2026/05/20 00:00 [revised] PHST- 2025/11/23 00:00 [received] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/09/03 17:36 [medline] PHST- 2026/06/22 06:46 [pubmed] PHST- 2026/06/22 04:23 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - JPN370491 [pii] AID - 10.1002/jpn3.70491 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2026 Sep;83(3):528-535. doi: 10.1002/jpn3.70491. Epub 2026 Jun 22. PMID- 42324459 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260908 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jun 22 TI - Determinants of out-of-home food consumption: development and validation of a multidimensional scale in a Brazilian sample. LID - 10.1186/s12889-026-28251-x [doi] LID - 2509 AB - BACKGROUND: Out-of-home food consumption has become an integral component of contemporary dietary patterns, particularly in urban contexts. Evidence suggests that eating outside the home is associated with diet quality, nutritional intake, and broader public health outcomes. However, Brazil lacks validated multidimensional instruments capable of comprehensively assessing the economic, behavioral, and experiential determinants underlying this behavior. This study aimed to develop and validate the Scale of Determinant Factors in Out-of-Home Food Consumption (SDF-OHFC) and to examine the structural relationships among its dimensions. METHODS: A cross-sectional study was conducted with 426 Brazilian adults who reported consuming food outside the home at least once per week. Data were collected through an online survey and analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM). The measurement model was assessed for reliability, convergent and discriminant validity. Structural relationships were tested using bootstrapping procedures (5,000 resamples), and predictive performance was evaluated through R(2), Q(2), RMSE, and MAE. Measurement invariance was examined across sex, marital status, and geographic regions. RESULTS: The SDF-OHFC comprises five dimensions: economic aspects, convenience, habits and personal preferences, social and experiential aspects, and perceived food quality. The scale demonstrated satisfactory internal consistency (Cronbach's alpha = 0.705-0.762), composite reliability (> 0.70), and convergent validity (AVE > 0.50). All hypothesized structural relationships were statistically significant (p < 0.05). Economic aspects played a central antecedent role, positively influencing convenience and habits, and negatively influencing social and experiential aspects. Convenience and social and experiential dimensions were positively associated with perceived food quality. Structural invariance was confirmed across all tested demographic groups. CONCLUSIONS: The SDF-OHFC is a valid and reliable multidimensional instrument for assessing determinants of out-of-home food consumption in Brazil. By integrating economic, behavioral, and experiential factors within a single framework, the scale supports public health research and policy development aimed at improving urban food environments, promoting healthier eating practices, and addressing structural determinants of dietary behavior. CI - (c) 2026. The Author(s). FAU - Lopes, Luis Felipe Dias AU - Lopes LFD AUID- ORCID: 0000-0002-2438-0226 AD - Federal University of Santa Maria, Santa Maria, Brazil. lflopes67@yahoo.com.br. FAU - Pegoraro, Daniela AU - Pegoraro D AD - Federal University of Santa Maria, Santa Maria, Brazil. FAU - de Oliveira, Rayssa Cleide AU - de Oliveira RC AD - Federal University of Santa Maria, Santa Maria, Brazil. FAU - Lopes, Eduarda Grando AU - Lopes EG AD - Federal University of Santa Maria, Santa Maria, Brazil. FAU - Saragozo, Rosangela Arruda AU - Saragozo RA AD - Federal University of Santa Maria, Santa Maria, Brazil. FAU - da Silva, Deoclecio Junior Cardoso AU - da Silva DJC AD - Pontifical Catholic University of Parana, Curitiba, Brazil. LA - eng PT - Journal Article PT - Validation Study DEP - 20260622 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Brazil MH - Female MH - Male MH - Cross-Sectional Studies MH - Adult MH - Reproducibility of Results MH - Middle Aged MH - *Feeding Behavior/psychology MH - Surveys and Questionnaires/standards MH - Young Adult MH - Adolescent MH - Socioeconomic Factors PMC - PMC13536861 OTO - NOTNLM OT - Brazil OT - Eating behavior OT - Food environment OT - Out-of-home food consumption OT - Psychometric validation OT - Public health COIS- Declarations. Ethical approval and consent to participate: This study was conducted in accordance with the ethical standards for research involving human participants. The research protocol was reviewed and approved by the Research Ethics Committee of the Federal University of Santa Maria, Brazil (Approval No. 4,469,026; CAAE: 40303720.5.0000.5346). All participants provided informed consent prior to participation. Data collection was anonymous, voluntary, and conducted in compliance with national and international ethical guidelines. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/22 00:43 MHDA- 2026/09/02 05:36 PMCR- 2026/06/22 CRDT- 2026/06/21 23:29 PHST- 2026/02/14 00:00 [received] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/09/02 05:36 [medline] PHST- 2026/06/22 00:43 [pubmed] PHST- 2026/06/21 23:29 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.1186/s12889-026-28251-x [pii] AID - 28251 [pii] AID - 10.1186/s12889-026-28251-x [doi] PST - epublish SO - BMC Public Health. 2026 Jun 22;26(1):2509. doi: 10.1186/s12889-026-28251-x. PMID- 42323926 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260820 IS - 1873-2364 (Electronic) IS - 0960-8966 (Linking) VI - 65 DP - 2026 Aug TI - Systematic review of outcome measures in facioscapulohumeral dystrophy (FSHD): validated, usable, and feasible tools for assessing function, performance, and strength. PG - 106470 LID - S0960-8966(26)00138-0 [pii] LID - 10.1016/j.nmd.2026.106470 [doi] AB - Facioscapulohumeral dystrophy (FSHD) is a dominantly inherited muscle-wasting condition with no approved therapies. Symptom variability complicates clinical evaluation, and despite the necessity of function-based measures to bridge research and real-world outcomes, no international consensus on a core assessment set exists. This systematic review evaluated the psychometric properties, feasibility, and comprehensiveness of published function-based outcome measures in FSHD, to help guide late-phase trials, and clinical practice. A systematic search of six databases with a data cut in January 2026 identified 366 studies and 51 outcome measures, which were appraised using the COSMIN framework. The results showed that while the FSHD Clinical Score, Clinical Severity Score, and 6-minute walk test are the most frequently utilised, no measure achieved higher than a 'Moderate' rating. Most supporting evidence remains 'Low,' with critical gaps identified for wheelchair users and paediatric populations. Digital outcome measures showed promise for improving responsiveness and enabling remote assessment.Our systematic review highlights an urgent need for a consensus-based approach to harmonize data together with international efforts such as MOVE/RESOLVE-FSHD providing direct support to upcoming initiatives like ENMC-FSHD-outcomes- workshop and the PaLaDIn project. Such efforts will allow researchers to enhance real-world evidence synthesis and improve success of future clinical trials. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Hewamadduma, Channa AU - Hewamadduma C AD - Academic Unit of Neuromuscular Disorders, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, , UK; Sheffield Institute of Translational Neurosciences (SITRAN), School of Medicine and Population Health, University of Sheffield, Sheffield, , UK. Electronic address: chewamadduma1@sheffield.ac.uk. FAU - Street, Jon AU - Street J AD - Academic Unit of Neuromuscular Disorders, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, , UK; Sheffield Institute of Translational Neurosciences (SITRAN), School of Medicine and Population Health, University of Sheffield, Sheffield, , UK. FAU - Massey, Charlotte AU - Massey C AD - Sheffield Institute of Translational Neurosciences (SITRAN), School of Medicine and Population Health, University of Sheffield, Sheffield, , UK. FAU - McDermott, Christopher J AU - McDermott CJ AD - Sheffield Institute of Translational Neurosciences (SITRAN), School of Medicine and Population Health, University of Sheffield, Sheffield, , UK. FAU - Weatherley, Emma AU - Weatherley E AD - FSHD Global Research Foundation, Sydney, Australia. FAU - Voermans, Nicol C AU - Voermans NC AD - Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands. FAU - Statland, Jeff AU - Statland J AD - Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA. FAU - Schoser, Benedikt AU - Schoser B AD - Friedrich-Baur-Institute, Department of Neurology LMU Clinic Munich, Munich, Germany. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260611 PL - England TA - Neuromuscul Disord JT - Neuromuscular disorders : NMD JID - 9111470 SB - IM MH - *Muscular Dystrophy, Facioscapulohumeral/physiopathology/diagnosis/therapy MH - Humans MH - *Outcome Assessment, Health Care MH - *Muscle Strength MH - Psychometrics MH - Severity of Illness Index OTO - NOTNLM OT - COSMIN OT - FSHD OT - Facioscapulohumeral muscular dystrophy OT - Outcome measures OT - Systematic review COIS- Declaration of competing interest CH: NCI/PI in clinical trials sponsored by UCB, Roche, Biogen, Avidity, Dyne, Argenx, JnJ, Remgen, Alexion, and Novartis and have received speaker honoraria and consultancy from UCB, Roche, Biogen, Avidity, Argenx, Alexion and Novartis. JS: received travel grant from FSHD Society CM: discloses the following conflicts of interest: Consultancy: Dyne therapeutics, Avidity, Lupin Neurosciences, Arthex Bio tech, PepGen. CJM: reports no conflicts of interest relevant to this work JS: received grant funding from NIH, CDC, MDA, FSHD Society, FSHD Canada, Friends of FSHD Research, ALSA; consultant or on scientific advisory board or steering committee for Avidity, Dyne, Roche, Novartis, Scholar Rock, Alnylam, Vertex, Souffle, Merck, and Sanofi NV: Consultancy: Avidity, Spolia, Astellas and Souffle (all financial compensation paid to her institution). BS: discloses the following conflicts of interest: Research support: DFG CAESAR, EU Horizon 2022 ComPASS; PaLaDIn; Entry-DM. Lecture support: Amicus, Alexion, Argenx, Astellas, Kedrion, Sanofi. Consultancy: Amicus, Astellas, Avidity, Denali, Dyne, Johnson&Johnson, Sanofi, Souffle, UCB. EDAT- 2026/06/21 22:33 MHDA- 2026/08/04 00:35 CRDT- 2026/06/21 17:59 PHST- 2026/04/18 00:00 [received] PHST- 2026/06/06 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/08/04 00:35 [medline] PHST- 2026/06/21 22:33 [pubmed] PHST- 2026/06/21 17:59 [entrez] AID - S0960-8966(26)00138-0 [pii] AID - 10.1016/j.nmd.2026.106470 [doi] PST - ppublish SO - Neuromuscul Disord. 2026 Aug;65:106470. doi: 10.1016/j.nmd.2026.106470. Epub 2026 Jun 11. PMID- 42323690 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260913 IS - 1750-1172 (Electronic) IS - 1750-1172 (Linking) VI - 21 IP - 1 DP - 2026 Jun 20 TI - Karyotype-specific cardiovascular and metabolic profiles in Turner syndrome: a retrospective echocardiographic study. LID - 10.1186/s13023-026-04457-5 [doi] LID - 315 AB - BACKGROUND: Turner syndrome (TS) is associated with cardiovascular abnormalities and metabolic risk, but karyotype-specific phenotypes remain incompletely defined, particularly in pediatric and adolescent cohorts assessed by transthoracic echocardiography (TTE). METHODS: We conducted a retrospective cross-sectional study of 289 patients with TS evaluated between October 2016 and October 2023. Patients were grouped as 45,X monosomy (n = 149) or mosaic/structural karyotypes (n = 140). Baseline or preoperative TTE data were used. The primary endpoint was a clinically relevant structural cardiovascular disease (CVD) composite based on explicit baseline/preoperative diagnoses of major lesions; patent foramen ovale, isolated persistent left superior vena cava, and minor valve regurgitation were treated as descriptive findings. Aortic dilatation based on ASI > 20 mm/m(2) was analyzed separately as an aortic-size phenotype. RESULTS: The structural CVD composite was more frequent in the 45,X group than in the mosaic/structural group (49/149 [32.9%] vs. 26/140 [18.6%], p = 0.006). In multivariable logistic regression, 45,X remained associated with the structural CVD composite after adjustment for age, BMI, systolic blood pressure, LDL-C, and HOMA-IR (OR 1.88, 95% CI 1.05-3.35; p = 0.033). Aortic dilatation by ASI > 20 mm/m(2) did not differ significantly between groups (28.9% vs. 32.9%, p = 0.462). Elevated total cholesterol was more frequent in the 45,X group, and LDL-C was independently associated with the structural CVD composite. LVDD was modestly lower in the 45,X group (33.6 +/- 6.6 vs. 35.4 +/- 6.4 mm; p = 0.017). CONCLUSIONS: In this single-center TS cohort, 45,X monosomy was associated with a higher burden of clinically relevant structural cardiovascular abnormalities and an adverse lipid profile, whereas ASI-defined aortic dilatation alone did not differ significantly by karyotype. These findings support karyotype-aware cardiovascular surveillance, while underscoring the need for cautious interpretation of small TTE differences and validation in multicenter longitudinal studies. CI - (c) 2026. The Author(s). FAU - Huang, Yinchun AU - Huang Y AD - Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. FAU - Luo, Song AU - Luo S AD - Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. FAU - Qi, Yiying AU - Qi Y AD - Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. FAU - Qin, Shuang AU - Qin S AD - Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. FAU - Yue, Chaomin AU - Yue C AD - Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. FAU - Lu, Qinsheng AU - Lu Q AD - Division of Uterine Vascular Biology, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. FAU - Lash, Gendie E AU - Lash GE AD - Division of Uterine Vascular Biology, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. FAU - Li, Li AU - Li L AUID- ORCID: 0000-0001-8832-0575 AD - Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. lilyli1973@126.com. LA - eng GR - 2023A1515010216/Science Fund for Distinguished Young Scholars of Guangdong Province/ GR - 2022B1515120074/Basic and Applied Basic Research Foundation of Guangdong Province/ GR - 2024A03J1175/Guangzhou Science, Technology and Innovation Commission/ PT - Journal Article DEP - 20260620 PL - England TA - Orphanet J Rare Dis JT - Orphanet journal of rare diseases JID - 101266602 SB - IM MH - Humans MH - *Turner Syndrome/genetics/metabolism/diagnostic imaging MH - Female MH - Retrospective Studies MH - Echocardiography/methods MH - Cross-Sectional Studies MH - Adolescent MH - Karyotype MH - Child MH - Cardiovascular Diseases/genetics/metabolism MH - Karyotyping PMC - PMC13563905 OTO - NOTNLM OT - 45,X OT - Aortic size index OT - Cardiovascular disease OT - Dyslipidemia OT - Echocardiography OT - Karyotype OT - Mosaicism OT - Turner syndrome COIS- Declarations. Ethics approval and consent to participate: The study protocol was reviewed and approved by the Scientific Research Ethics Committee of Guangzhou Women and Children's Medical Center, Guangzhou Medical University (approval No. Sui Fu Er Ke Lun Pi Zi [2025] No. 261A01; approval date: 14 August 2025). Informed consent was obtained from participants and/or their legal guardians in accordance with the approved protocol. All data were analyzed in aggregate form without identifying individual participants. Consent for publication: Informed consent for the publication of data was obtained from all participants or their legal caregivers. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/06/21 22:34 MHDA- 2026/09/11 05:36 PMCR- 2026/06/20 CRDT- 2026/06/20 23:27 PHST- 2025/12/24 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/09/11 05:36 [medline] PHST- 2026/06/21 22:34 [pubmed] PHST- 2026/06/20 23:27 [entrez] PHST- 2026/06/20 00:00 [pmc-release] AID - 10.1186/s13023-026-04457-5 [pii] AID - 4457 [pii] AID - 10.1186/s13023-026-04457-5 [doi] PST - epublish SO - Orphanet J Rare Dis. 2026 Jun 20;21(1):315. doi: 10.1186/s13023-026-04457-5. PMID- 42322639 OWN - NLM STAT- MEDLINE DCOM- 20260620 LR - 20260620 IS - 1464-3502 (Electronic) IS - 0735-0414 (Linking) VI - 61 IP - 4 DP - 2026 May 13 TI - Interpretable machine learning for rare events: an inverse probability weighted application to understanding glucagon-like peptide-1 receptor agonists use and incident alcohol-related disorder. LID - agag045 [pii] LID - 10.1093/alcalc/agag045 [doi] AB - OBJECTIVE: Large administrative datasets enable investigation of rare outcomes, but accurate individual-level prediction remains challenging. Emerging evidence suggests that glucagon-like peptide-1 receptor agonists (GLP-1 RAs), used to treat diabetes and obesity, may reduce alcohol craving and intake. We examined predictors of incident alcohol-related disorder (ARD) using inverse probability-weighted (IPW) machine learning models, focusing on GLP-1 RA use. METHODS: We conducted a retrospective cohort study using the MarketScan Multi-State Medicaid Database (N = 96 460). Type 2 diabetic adults aged 18-64 years with GLP-1 RA prescription coverage (2022-2023) and no ARD in 2022 were included. Baseline variables included demographics, social risk factors (Z-codes), comorbidities, insurance characteristics, and GLP-1 RA use. Propensity scores were used to derive stabilized IPW weights to adjust for confounding in GLP-1 RA exposure. An Extreme Gradient Boosting model with IPW was trained using a 70/30 train-test split with five-fold cross-validation and probability calibration. Performance was evaluated using Area Under the Receiver Operating Characteristics Curve (AUROC), recall, and precision. Model interpretability was assessed using SHapley Additive exPlanations (SHAP). RESULTS: GLP-1 RAs were used by 21.7% of individuals; 2.1% (N = 2004) developed incident ARD. The model demonstrated modest discrimination (AUROC = 0.67). Recall and precision were 0.28 and 0.05, respectively. SHAP analysis ranked GLP-1 RA use as the sixth most influential predictor and showed an association with lower predicted ARD risk. CONCLUSION: Predicting rare outcomes remains difficult, particularly for identifying positive cases. Interpretable machine learning identified GLP-1 RA use as an important feature associated with lower predicted ARD risk, warranting further investigation. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Medical Council on Alcohol and Oxford University Press. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Gautam, Rinoj AU - Gautam R AD - College of Pharmacy, UNT Health, Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, United States. FAU - Wang, Hao AU - Wang H AUID- ORCID: 0000-0002-5105-0951 AD - Department of Emergency Medicine, JPS Health Network, 1500 S. Main St., Fort Worth, TX 76104, United States. FAU - Zhou, Bo AU - Zhou B AD - College of Pharmacy, UNT Health, Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, United States. FAU - Neba, Rolake AU - Neba R AD - College of Pharmacy, UNT Health, Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, United States. FAU - Sambamoorthi, Usha AU - Sambamoorthi U AD - Health Outcomes Research and AI Innovation, Department of Pharmacy Practice, School of Pharmacy, Temple University, 1801 N. Broad St., Philadelphia, PA 19140, United States. LA - eng GR - 5S21MD012472-05/National Institute on Minority Health and Health Disparities through the Texas Center for Health Disparities (NIMHD)/ GR - 1OT2OD032581-01/National Institutes of Health/Artificial Intelligence/Machine Learning Consortium to Advance Health Equity and Researcher Diversity/ PT - Journal Article PL - England TA - Alcohol Alcohol JT - Alcohol and alcoholism (Oxford, Oxfordshire) JID - 8310684 RN - 0 (Glucagon-Like Peptide-1 Receptor Agonists) SB - IM MH - Humans MH - *Glucagon-Like Peptide-1 Receptor Agonists MH - *Machine Learning MH - Retrospective Studies MH - Female MH - Adult MH - Middle Aged MH - Male MH - Predictive Learning Models MH - *Diabetes Mellitus, Type 2/drug therapy MH - *Alcohol-Related Disorders/epidemiology MH - Young Adult MH - United States/epidemiology MH - Adolescent MH - Prediction Algorithms MH - Probability MH - Boosting Machine Learning Algorithms OTO - NOTNLM OT - GLP-1 receptor agonists OT - Medicaid OT - alcohol-related disorder OT - inverse probability weighting OT - machine learning EDAT- 2026/06/21 22:34 MHDA- 2026/06/21 22:35 CRDT- 2026/06/20 14:33 PHST- 2026/03/17 00:00 [received] PHST- 2026/05/14 00:00 [revised] PHST- 2026/05/16 00:00 [accepted] PHST- 2026/06/21 22:35 [medline] PHST- 2026/06/21 22:34 [pubmed] PHST- 2026/06/20 14:33 [entrez] AID - 8712561 [pii] AID - 10.1093/alcalc/agag045 [doi] PST - ppublish SO - Alcohol Alcohol. 2026 May 13;61(4):agag045. doi: 10.1093/alcalc/agag045. PMID- 42321595 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261014 IS - 1098-108X (Electronic) IS - 0276-3478 (Print) IS - 0276-3478 (Linking) VI - 59 IP - 10 DP - 2026 Oct TI - Comparative Properties of Two Self-Report Measures of Avoidant/Restrictive Food Intake Disorder: Psychometric and Clinical Utility. PG - 2226-2236 LID - 10.1002/eat.70151 [doi] AB - OBJECTIVES: We compared two measures of Avoidant/Restrictive Food Intake Disorder (ARFID)-the NIAS and the PARDI-AR-Q to determine which demonstrates better psychometric and clinical utility. METHODS: The study was pre-registered (OSF; DOI 10.17605/OSF.IO/N8WBF). Participants (aged >/= 18 years, BMI > 18.5) were recruited via Prolific and screened via a short written description of their fussy eating behaviors. After review, eligible participants (N = 156) were invited to complete a second online survey, consisting of the NIAS, PARDI-AR-Q, GAD-7, PHQ-9, CIA, and EDE-Q7. Exploratory factor analyses were conducted separately for the NIAS and PARDI-AR-Q dimensions, and then on combined items. Pearson's correlations examined associations within and across both ARFID measures. Categorical agreement between measures was examined. Correlations and multiple regressions determined the extent to which ARFID subscales accounted for variance across the broader clinical outcomes. RESULTS: All subscales within and across the NIAS and PARDI-AR-Q were significantly and positively correlated. The weakest association was observed between the NIAS Picky Eating subscale and the PARDI-AR-Q Sensory Sensitivity subscale-a pattern supported by the combined exploratory factor analysis, which yielded a four-factor model. The NIAS and PARDI-AR-Q showed significant, moderate case agreement. The PARDI-AR-Q showed much stronger evidence of clinical validity. DISCUSSION: Overall, the PARDI-AR-Q demonstrated greater clinical validity than the NIAS. The weak association between Picky Eating and Sensory Sensitivity suggests these measures capture distinct behavioral and motivational components of ARFID. CI - (c) 2026 The Author(s). International Journal of Eating Disorders published by Wiley Periodicals LLC. FAU - Nicholls-Clow, Rebecca AU - Nicholls-Clow R AUID- ORCID: 0009-0007-9941-5415 AD - School of Psychology, University of Sheffield, Sheffield, UK. FAU - Prudenzi, Arianna AU - Prudenzi A AUID- ORCID: 0000-0002-5185-2807 AD - School of Psychology, University of Sheffield, Sheffield, UK. FAU - Waller, Glenn AU - Waller G AUID- ORCID: 0000-0001-7794-9546 AD - Department of Psychology, University of Warwick, Coventry, UK. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260619 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM MH - Humans MH - Psychometrics MH - Female MH - Adult MH - Male MH - *Self Report MH - *Avoidant Restrictive Food Intake Disorder/diagnosis/psychology MH - Young Adult MH - Adolescent MH - Surveys and Questionnaires MH - Middle Aged MH - Reproducibility of Results MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Factor Analysis, Statistical PMC - PMC13655934 OTO - NOTNLM OT - Avoidant/Restrictive Food Intake Disorder (ARFID) OT - NIAS OT - PARDI-AR-Q OT - clinical utility OT - eating disorders OT - psychometrics OT - self-report measures COIS- The authors declare no conflicts of interest. EDAT- 2026/06/20 00:37 MHDA- 2026/10/12 11:41 PMCR- 2026/10/12 CRDT- 2026/06/19 23:26 PHST- 2026/04/29 00:00 [revised] PHST- 2026/02/26 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/10/12 11:41 [medline] PHST- 2026/06/20 00:37 [pubmed] PHST- 2026/06/19 23:26 [entrez] PHST- 2026/10/12 00:00 [pmc-release] AID - EAT70151 [pii] AID - 10.1002/eat.70151 [doi] PST - ppublish SO - Int J Eat Disord. 2026 Oct;59(10):2226-2236. doi: 10.1002/eat.70151. Epub 2026 Jun 19. PMID- 42321360 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20261007 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jun 19 TI - Medicine ball throw distance weighted with height-to-mass ratio aligns with other physical fitness tasks. LID - 10.1038/s41598-026-58353-w [doi] LID - 28114 AB - The traditional Medicine Ball Throw (MBT(T)) for assessing upper-extremity explosive strength inherently favours heavier and taller participants. We designed three alternative indices to adjust for this anthropometric bias: (1) multiplying MBT(T) by the height-to-mass ratio (MBT(A1)), (2) dividing MBT(T) by the product of mass and height (MBT(A2)), and (3) dividing MBT(T) by the body mass index (MBT(A3)). Using age- and sex-adjusted LMS-based z-scores from two independent cohorts (821 children, aged 8.3 +/- 0.7 years; 354 adolescents, aged 14.4 +/- 2.2 years), we compared the variants' alignment with the concave BMI-profiles of five standard fitness tests (6-minute run, standing long jump, jump sideways, 4 x 10 m shuttle run, push-ups). The three anthropometrically enriched variants yielded significantly better goodness of fit than MBT(T) with MBT(A1) performing best overall. Furthermore, when deployed as independent covariates, the enriched indices demonstrated systematically higher predictive power for standard fitness tasks than the unadjusted distance. We recommend adjusting MBT(T) via the height-to-mass ratio for a fairer assessment, though its structural overlap with BMI requires caution in predictive models. CI - (c) 2026. The Author(s). FAU - Jarnig, Gerald AU - Jarnig G AUID- ORCID: 0000-0003-0885-5866 AD - Department of Human Movement Science, Sport and Health, University of Graz, Mozartgasse 14, Graz, Austria. gerald.jarnig@uni-graz.at. FAU - Kliegl, Reinhold AU - Kliegl R AUID- ORCID: 0000-0002-0180-8488 AD - Department of Sports and Health Sciences, Division of Training and Movement Sciences, University of Potsdam, Potsdam, Germany. FAU - Kerbl, Reinhold AU - Kerbl R AUID- ORCID: 0009-0007-3567-2877 AD - Department of Pediatrics and Adolescent Medicine, LKH Hochsteiermark, Leoben, Austria. FAU - van Poppel, Mireille N M AU - van Poppel MNM AUID- ORCID: 0000-0001-5694-4324 AD - Department of Human Movement Science, Sport and Health, University of Graz, Mozartgasse 14, Graz, Austria. LA - eng GR - GZ:2025-0.021.608/Austrian Federal Ministry for Arts, Culture, Civil Service and Sport/ GR - GZ:2024-0.780.614/Austrian Federal Ministry of Education, Science and Research/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260619 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Physical Fitness/physiology MH - Body Mass Index MH - Adolescent MH - Female MH - Male MH - Child MH - *Body Height MH - Exercise Test/methods MH - Anthropometry PMC - PMC13554187 OTO - NOTNLM OT - Anthropometry OT - Athletic performance OT - Height-to-mass ratio OT - Medicine ball throw OT - Model validation OT - Physical fitness OT - Upper body strength COIS- Declarations. Competing interests: The authors declare no competing interests. Institutional review board: The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Research Ethics Committee of the University of Graz, Styria, Austria (GZ. 39/68/63 ex 2021/22). Informed consent: Informed consent was obtained from all the subjects involved in the study. EDAT- 2026/06/20 00:37 MHDA- 2026/09/09 07:07 PMCR- 2026/06/19 CRDT- 2026/06/19 23:20 PHST- 2026/02/07 00:00 [received] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/09/09 07:07 [medline] PHST- 2026/06/20 00:37 [pubmed] PHST- 2026/06/19 23:20 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - 10.1038/s41598-026-58353-w [pii] AID - 58353 [pii] AID - 10.1038/s41598-026-58353-w [doi] PST - epublish SO - Sci Rep. 2026 Jun 19;16(1):28114. doi: 10.1038/s41598-026-58353-w. PMID- 42321344 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20261005 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jun 19 TI - Associations of lifestyle and biological factors with body image among reproductive-aged women: a cross-sectional study. LID - 10.1038/s41598-026-56798-7 [doi] LID - 28125 AB - This study aimed to identify lifestyle and biological factors associated with body image among reproductive-aged women, focusing on physical activity, sedentary time, sleep, BMI, premenstrual symptoms (PMS), and sleep quality. A secondary aim was to explore interrelationships among these factors to contextualise their combined association with body image. In this cross-sectional online survey, 291 women aged 18-45 years participated (mean age: 27.16 +/- 0.36 years). Validated questionnaires were used to assess body image (Body Appreciation Scale), physical activity (Global Physical Activity Questionnaire), sleep quality (Sleep Quality Scale), BMI, and PMS (Premenstrual Assessment Form-Short Form). Data were analysed with IBM SPSS 28.0 using multivariable linear regression and correlation analyses (p < 0.05). Higher BMI, greater PMS severity, poorer sleep quality and longer sedentary time were significantly associated with lower body appreciation. Correlations were found between PMS and sleep quality (r = 0.309; p < 0.001), PMS and work-related moderate activity (r = 0.119; p = 0.043), and sleep quality and work-related moderate activity (r = 0.169; p = 0.004). No significant associations were observed for recreational physical activity with PMS (r=-0.041; p = 0.544) or sleep quality (r=-0.040; p = 0.498). Body image in reproductive-aged women was associated with both lifestyle behaviours and biological symptom burden. The findings suggest that supporting positive body image may benefit from integrated approaches addressing sedentary behaviour, sleep quality and menstrual health alongside weight-related factors. CI - (c) 2026. The Author(s). FAU - Dozsa-Juhasz, Olivia AU - Dozsa-Juhasz O AD - Institute of Physiotherapy and Sport Science, Faculty of Health Sciences, University of Pecs, Pecs, Hungary. FAU - Premusz, Viktoria AU - Premusz V AD - Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pecs, Pecs, Hungary. FAU - Acs, Pongrac AU - Acs P AD - Physical Activity Research Group, Szentagothai Research Centre, University of Pecs, Pecs, Hungary. FAU - Hock, Marta AU - Hock M AD - Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pecs, Pecs, Hungary. FAU - Makai, Alexandra AU - Makai A AD - Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pecs, Pecs, Hungary. alexandra.makai@etk.pte.hu. LA - eng PT - Journal Article DEP - 20260619 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Adult MH - Cross-Sectional Studies MH - *Body Image/psychology MH - *Life Style MH - Middle Aged MH - Body Mass Index MH - Young Adult MH - Adolescent MH - Surveys and Questionnaires MH - Exercise MH - Sleep Quality MH - Sedentary Behavior MH - Premenstrual Syndrome/psychology MH - Sleep MH - Body Satisfaction PMC - PMC13554112 OTO - NOTNLM OT - 24-hour movement behaviours OT - Body image OT - Premenstrual syndrome OT - Sleep quality OT - Women's health COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: The study was registered by the U.S. National Institute of Health (clinicaltrial.gov, Identifier: NCT06146673; date of registration: 23/11/2023) and approved by the Medical Research Council of Hungary (Identifier: BM/23899-1/2023). A research protocol adhering to the principles of the Helsinki Declaration was followed. Participants provided voluntary, uninfluenced consent for the anonymous use and publication of their data following appropriate information provision. EDAT- 2026/06/20 00:38 MHDA- 2026/09/09 07:07 PMCR- 2026/06/19 CRDT- 2026/06/19 23:19 PHST- 2025/11/04 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/09/09 07:07 [medline] PHST- 2026/06/20 00:38 [pubmed] PHST- 2026/06/19 23:19 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - 10.1038/s41598-026-56798-7 [pii] AID - 56798 [pii] AID - 10.1038/s41598-026-56798-7 [doi] PST - epublish SO - Sci Rep. 2026 Jun 19;16(1):28125. doi: 10.1038/s41598-026-56798-7. PMID- 42318005 OWN - NLM STAT- MEDLINE DCOM- 20260619 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Machine learning-based prediction models for severe Mycoplasma pneumoniae pneumonia in Chinese children: a systematic review and meta-analysis of prediction model performance. PG - 1793116 LID - 10.3389/fpubh.2026.1793116 [doi] LID - 1793116 AB - OBJECTIVES: This study aimed to systematically evaluate the predictive performance and methodological characteristics of machine learning-based models for predicting progression to severe Mycoplasma pneumoniae pneumonia (SMPP) in pediatric patients. METHODS: A comprehensive literature search was conducted in PubMed, EMBASE, Web of Science, Cochrane Library, CNKI, and Wanfang databases from inception to November 2025 to identify studies developing or validating prediction models for SMPP in children. Data on study characteristics, modeling algorithms, predictors, and performance metrics were extracted. A narrative synthesis was performed to summarize model characteristics, predictors, and modeling approaches, while model discrimination was quantitatively synthesized using pooled area under the receiver operating characteristic curve (AUC). Subgroup analyses were conducted according to modeling algorithms. Methodological quality and risk of bias were assessed using the PROBAST tool. RESULTS: A total of 13 studies were included. The reported prevalence of hypoglycemia ranged from 17 to 33%. The AUC for predictive models ranged from 0.81 to 0.90. Subgroup analyses showed that machine learning-based models such as XGBoost and random forest generally reported higher AUC values compared with other modeling approaches. Commonly reported predictors included age, insulin use, body mass index, HbA1c, creatinine, and history of hypoglycemia. CONCLUSION: Research on risk prediction models for SMPP in children is still at a developmental stage. Although current models demonstrate high discriminatory performance, methodological limitations and limited clinical translation remain. Future studies should focus on developing robust, interpretable machine learning models and facilitating their integration into pediatric clinical practice. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/ CRD42020190338. CI - Copyright (c) 2026 Cao, Nie, Wu and Liu. FAU - Cao, Juan AU - Cao J AD - College of Medicine and Health Sciences, China Three Gorges University, Yichang, Hubei, China. FAU - Nie, Jiao AU - Nie J AD - Department of Nursing, Jiangxi Provincial Children's Hospital, Nanchang, Jiangxi, China. FAU - Wu, Danxia AU - Wu D AD - Department of Respiratory Medicine, Jiangxi Provincial Children's Hospital, Nanchang, Jiangxi, China. FAU - Liu, Huiqin AU - Liu H AD - The First College of Clinical Medicine, China Three Gorges University, Yichang Central People's Hospital, Yichang, China. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260603 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - Chinese people SB - IM MH - Child MH - Humans MH - Boosting Machine Learning Algorithms MH - China/epidemiology MH - *Machine Learning MH - Mycoplasma pneumoniae MH - *Pneumonia, Mycoplasma/diagnosis/epidemiology MH - Predictive Learning Models MH - East Asian People PMC - PMC13272165 OTO - NOTNLM OT - machine learning OT - meta-analysis OT - pediatrics OT - prediction model OT - severe Mycoplasma pneumoniae pneumonia COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/19 06:32 MHDA- 2026/06/19 06:33 PMCR- 2026/06/03 CRDT- 2026/06/19 04:53 PHST- 2026/01/21 00:00 [received] PHST- 2026/05/13 00:00 [revised] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/06/19 06:33 [medline] PHST- 2026/06/19 06:32 [pubmed] PHST- 2026/06/19 04:53 [entrez] PHST- 2026/06/03 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1793116 [doi] PST - epublish SO - Front Public Health. 2026 Jun 3;14:1793116. doi: 10.3389/fpubh.2026.1793116. eCollection 2026. PMID- 42316462 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260619 LR - 20260813 IS - 1738-3684 (Print) IS - 1976-3026 (Electronic) IS - 1738-3684 (Linking) VI - 23 IP - 6 DP - 2026 Jun TI - Paraben and Phthalate Exposure in Adolescents With Attention-Deficit/Hyperactivity Disorder: A Case-Control Study. PG - 773-789 LID - 10.30773/pi.2025.0444 [doi] AB - OBJECTIVE: This case-control study compared urinary concentrations of parabens and phthalate metabolites between adolescents with attention-deficit/hyperactivity disorder (ADHD) and healthy peers and examined whether product-use behaviors accounted for observed exposure differences. METHODS: Adolescents aged 12-17 years with clinically diagnosed ADHD (n=39) and age- and sex-matched healthy controls (n=41) were recruited. Urinary concentrations of seven parabens and ten phthalate metabolites were quantified using validated high-performance liquid chromatography and gas chromatography-mass spectrometry protocols. ADHD symptoms were assessed using Conners Parent and Adolescent Rating Scales. Group comparisons were conducted using t-tests with effect sizes (Cohen's d). Multivariable logistic regression, factorial analysis of covariance (ANCOVA) models (reporting partial eta(2)), and multiple mediation analyses were performed, adjusting for household income, parental education, and body mass index. RESULTS: Differences in the urinary concentrations of several parabens and phthalate metabolites were observed between adolescents with ADHD and controls. However, detection frequencies varied across analytes, and findings for compounds with low detection frequency should be interpreted with caution. In multivariable logistic regression, an association between dimethyl phthalate and ADHD status was observed (odds ratio=6.13; 95% confidence interval, 1.10-34.34), with improved model discrimination (Deltachi(2)=17.2, p=0.002; area under the receiver operating characteristic curve, 0.856-->0.921); however, this finding should be interpreted with caution given its low detection frequency. In ANCOVA models adjusting for product-use behaviors, group differences remained significant only for dimethyl phthalate (F(1, 71)=7.97, p=0.006, eta(2)=0.099); however, this finding should likewise be interpreted with caution due to its low detection frequency. Mediation analyses indicated that recent personal care product use did not substantially mediate the association between ADHD status and chemical exposure levels. CONCLUSION: Adolescents with ADHD showed differences in internal exposure to selected parabens and phthalate metabolites. These findings should be interpreted with caution, particularly for analytes with low detection frequency. Overall, these findings suggest that exposure differences may reflect behavior-linked vulnerability patterns during adolescence rather than short-term cosmetic use alone. Longitudinal studies are needed to clarify temporal and causal pathways. FAU - Terzioglu, Merve Aktas AU - Terzioglu MA AD - Pamukkale University, Faculty of Medicine, Department of Child and Adolescent Psychiatry, Denizli, Turkiye. merveaktasterzioglu@gmail.com. FAU - Patlar, Seyfiye AU - Patlar S AD - Pamukkale University, Faculty of Medicine, Department of Child and Adolescent Psychiatry, Denizli, Turkiye. FAU - Onac, Canan AU - Onac C AD - Pamukkale University, Faculty of Science, Department of Chemistry and Advanced Technology Application and Research Center, Denizli, Turkiye. FAU - Cort, Aysegul AU - Cort A AD - Pamukkale University, Faculty of Medicine, Department of Biochemistry, Denizli, Turkiye. FAU - Ata, Melek Tunc AU - Ata MT AD - Pamukkale University, Faculty of Medicine, Department of Physiology, Denizli, Turkiye. LA - eng GR - 2023IAP003/Pamukkale University/ PT - Journal Article DEP - 20260608 PL - Korea (South) TA - Psychiatry Investig JT - Psychiatry investigation JID - 101242994 PMC - PMC13284555 OTO - NOTNLM OT - ADHD OT - Adolescent mental health OT - Paraben exposure OT - Personal care products OT - Phthalate exposure COIS- Conflicts of Interest The authors have no potential conflicts of interest to disclose. EDAT- 2026/06/19 06:33 MHDA- 2026/06/19 06:34 PMCR- 2026/06/01 CRDT- 2026/06/19 00:39 PHST- 2025/12/04 00:00 [received] PHST- 2026/04/01 00:00 [accepted] PHST- 2026/06/19 06:34 [medline] PHST- 2026/06/19 06:33 [pubmed] PHST- 2026/06/19 00:39 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - pi.2025.0444 [pii] AID - pi-2025-0444 [pii] AID - 10.30773/pi.2025.0444 [doi] PST - ppublish SO - Psychiatry Investig. 2026 Jun;23(6):773-789. doi: 10.30773/pi.2025.0444. Epub 2026 Jun 8. PMID- 42316363 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260619 LR - 20260813 IS - 3059-4057 (Electronic) IS - 3059-4057 (Linking) VI - 12 IP - 1 DP - 2026 Jun 19 TI - Pulmonary adverse events associated with GLP-1 receptor agonists: a systematic review of respiratory safety signals. LID - 10.1186/s40842-026-00311-6 [doi] LID - 43 AB - BACKGROUND: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are among the most rapidly growing drug classes in contemporary medicine, approved for type 2 diabetes mellitus (T2DM) and obesity management. Although gastrointestinal adverse effects are well characterised, the pulmonary safety profile of GLP-1 RAs remains incompletely defined, representing an important evidence gap given the scale of global prescribing. OBJECTIVE: This systematic review aims to synthesise published evidence on respiratory adverse events temporally associated with GLP-1 RA therapy in adults, characterise their patterns and severity, appraise the risk of bias using validated design-appropriate tools, describe proposed pathophysiological mechanisms, and grade the certainty of evidence using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework. Given the heterogeneity of the included evidence-spanning case reports, pharmacovigilance analyses, and observational cohorts-this review is framed primarily as a signal-detection and evidence-mapping exercise rather than a causal-inference analysis. ELIGIBILITY CRITERIA: Adults (>/= 18 years) receiving any approved GLP-1 RA for any indication. Eligible study designs included randomised controlled trials (RCTs), retrospective and prospective observational cohorts, pharmacovigilance disproportionality analyses, and case reports or series. Studies were excluded if they enrolled paediatric populations, involved animal or in vitro experiments, reported only metabolic or cardiovascular outcomes without respiratory adverse-event data, or were narrative reviews, editorials, or commentaries without primary data. METHODS: A systematic review was conducted following PRISMA 2020 guidelines (PROSPERO: CRD420261305875). PubMed, Embase, and Scopus were searched from inception to January 2026. Risk of bias was assessed using the Cochrane Risk of Bias 2 (RoB2) tool for RCTs, the Newcastle-Ottawa Scale (NOS) for cohort studies, and Joanna Briggs Institute (JBI) checklists for case reports, case series, and pharmacovigilance studies. GRADE was applied at the outcome-domain level; evidence from uncontrolled designs (case reports, case series, pharmacovigilance analyses) was initially rated very low certainty, as these designs are inherently uncontrolled and start below the lowest GRADE tier. Given substantial heterogeneity, meta-analytic pooling was not performed; a pre-specified narrative synthesis following the Synthesis Without Meta-Analysis (SWiM) reporting guideline was conducted. RESULTS: Nineteen studies met inclusion criteria: four RCTs (n = 1,884 participants), five retrospective cohort studies (n = 1,122,653 participants), three pharmacovigilance analyses (n = 498,892 spontaneous adverse-event reports), and seven case reports or case series (n = 13 patients). Spontaneous reports do not represent unique exposed individuals and were not pooled with participant counts. Risk of bias: all four RCTs were rated low risk by RoB2 (with some concerns for open-label outcome ascertainment in three trials, a domain-specific issue that does not alter the overall RoB2 category from low); three of five cohort studies were rated moderate and one high risk by NOS (one cohort study rating not reported, classified as not reported/unable to rate); all three pharmacovigilance studies were rated high risk by JBI; and case reports were rated as methodologically adequate by JBI, though these instruments cannot overcome the inherent anecdotal nature and very limited generalisability of single-case designs. Upper respiratory tract infections (URTIs) were the most frequently reported adverse event (8 of 12 reporting studies, 66.7%), occurring at rates comparable to controls across RCTs (GRADE: MODERATE certainty). Pharmacovigilance analyses identified disproportionate reporting signals for dyspnoea and asthma-like events, particularly with exenatide, using the reporting odds ratio (ROR 2.14, 95% CI 1.88-2.43; Cazzola 2024); these signals are hypothesis-generating only and do not establish causality or incidence. Serious adverse events reported in temporal association with GLP-1 RA exposure included anaphylaxis with bronchospasm (n = 4 cases), acute eosinophilic pneumonia (n = 1), perioperative aspiration pneumonitis or pneumonia (multiple perioperative cases across two cohort studies and one case series), acute respiratory distress syndrome (ARDS; n = 2, one fatal requiring extracorporeal membrane oxygenation [ECMO]), and spontaneous pneumomediastinum (n = 1). A large global retrospective cohort study (n = 331,863 matched patients; Henney 2024) demonstrated a potentially meaningful reduction in incident pneumonia with GLP-1 RAs compared with dipeptidyl peptidase-4 (DPP-4) inhibitors (hazard ratio [HR] 0.60, 95% confidence interval [CI] 0.58-0.62; GRADE: LOW certainty); this finding should be interpreted cautiously given the retrospective design, active and non-inert comparator, and likelihood of residual confounding. Evidence certainty for serious respiratory events was very low, driven by sparse case reports and high-risk pharmacovigilance data. CONCLUSION: GLP-1 RA therapy has a respiratory safety profile that is neither uniformly benign nor hazardous, stratified by mechanism, agent subclass, and clinical context. Common upper airway symptoms are mild and comparable to controls. Rare but clinically consequential events-including anaphylaxis, eosinophilic pneumonia, perioperative aspiration, and ARDS-have been reported in temporal association with GLP-1 RA exposure, predominantly in case reports and pharmacovigilance data of very low certainty; these signals are hypothesis-generating and should not be interpreted as confirmed causal risks. Exendin-4-based agents (exenatide and lixisenatide) appear to carry the highest reported risk of hypersensitivity reactions, attributable to their non-human structural origin. Clinicians should maintain heightened awareness for aspiration risk in perioperative settings; individualised, extended pre-procedural fasting intervals calibrated to the specific agent's pharmacokinetic profile should be considered. Prospective, standardised, and adequately powered studies with pre-specified respiratory endpoints are required to move from signal detection to causal inference. CI - (c) 2026. The Author(s). FAU - Ahuja, Aarushi AU - Ahuja A AD - Department of Internal Medicine, Maulana Azad Medical College, New Delhi, Delhi, India. FAU - Prasad, Sai AU - Prasad S AD - Department of Internal Medicine, S. Nijalingappa Medical College, Navanagar, Bagalkote, Karnataka, 587102, India. saiprasad.jadi@gmail.com. FAU - Manoharan, Sahana AU - Manoharan S AD - Department of Internal Medicine, Tirunelveli Medical College, Tirunelveli, Tamil Nadu, India. FAU - Sen, Arya AU - Sen A AD - Department of Internal Medicine, Medical College and Hospital Kolkata, Kolkata, West Bengal, India. FAU - Rana, Richa AU - Rana R AD - Department of Internal Medicine, GMERS Medical College Sola, Ahmedabad, Gujarat, India. FAU - Mody, Mansi AU - Mody M AD - Department of Internal Medicine, MP Shah Government Medical College, Jamnagar, Gujarat, India. FAU - Paras, Fnu AU - Paras F AD - Department of Internal Medicine, Government Medical College Patiala, Patiala, Punjab, India. FAU - Archita, Archita AU - Archita A AD - Department of Internal Medicine, Ziauddin University, Karachi, Pakistan. FAU - Shaik, Sana AU - Shaik S AD - Department of Internal Medicine, Tbilisi State Medical University, Tbilisi, Georgia. FAU - Mehta, Kartik AU - Mehta K AD - Department of Internal Medicine, Maulana Azad Medical College, New Delhi, Delhi, India. FAU - Manoj, Rachel AU - Manoj R AD - Department of Internal Medicine, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova. FAU - Mishra, Prakashini AU - Mishra P AD - Department of Internal Medicine, Government Medical College, Chandigarh, India. FAU - Mehta, Subhi AU - Mehta S AD - Department of Internal Medicine, LLRM Medical College, Meerut, Uttar Pradesh, India. FAU - Kapoor, Pulkit AU - Kapoor P AD - Department of Internal Medicine, Punjab Institute of Medical Sciences, Jalandhar, Punjab, India. LA - eng PT - Journal Article PT - Review DEP - 20260619 PL - England TA - Cardiovasc Diabetol Endocrinol Rep JT - Cardiovascular diabetology. Endocrinology reports JID - 9918994893106676 PMC - PMC13281493 OTO - NOTNLM OT - Aspiration pneumonia OT - Exenatide OT - GLP-1 receptor agonists OT - GRADE OT - Liraglutide OT - Pharmacovigilance OT - Pulmonary adverse events OT - Respiratory safety OT - Semaglutide OT - Systematic review COIS- Declarations. Ethics approval and consent to participate: Not applicable. This study is a systematic review of previously published data and does not involve human participants or patient-level identifiable data. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/19 06:33 MHDA- 2026/06/19 06:34 PMCR- 2026/06/19 CRDT- 2026/06/19 00:19 PHST- 2026/03/27 00:00 [received] PHST- 2026/04/30 00:00 [accepted] PHST- 2026/06/19 06:34 [medline] PHST- 2026/06/19 06:33 [pubmed] PHST- 2026/06/19 00:19 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - 10.1186/s40842-026-00311-6 [pii] AID - 311 [pii] AID - 10.1186/s40842-026-00311-6 [doi] PST - epublish SO - Cardiovasc Diabetol Endocrinol Rep. 2026 Jun 19;12(1):43. doi: 10.1186/s40842-026-00311-6. PMID- 42316345 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260905 IS - 1471-244X (Electronic) IS - 1471-244X (Linking) VI - 26 IP - 1 DP - 2026 Jun 18 TI - Suicidal ideation and suicide attempts among adolescents and youth in the aftermath of the Tigray war, 2024: prevalence and associated factors. LID - 10.1186/s12888-026-08284-7 [doi] LID - 687 AB - BACKGROUND: Suicide is a leading cause of death among adolescents and youth globally and represents an important public health concern in low- and middle-income and conflict-affected settings. Prior evidence from Ethiopia showed substantial levels of suicidal behavior among young populations even before the recent conflict. Exposure to war-related trauma, violence, displacement, and disruption of health and social systems may further increase the risk of suicidality among adolescents and youth. However, there is limited evidence regarding suicidal ideation and suicide attempts among adolescents and youth in post-war Tigray, Ethiopia. Therefore, this study aimed to assess the prevalence and associated factors of suicidal ideation and suicide attempts among adolescents and youth in the aftermath of the Tigray War. METHODS: A school-based cross-sectional study was conducted among 599 adolescents and youth aged 15-24 years in post-war Tigray, Ethiopia, of whom 57.4% were female. Data were collected using validated tools assessing suicidal ideation, suicide attempts, depression, anxiety, post-traumatic stress disorder, and exposure to violence. Bivariate and multivariable logistic regression analyses were performed to identify factors associated with suicidal ideation and suicide attempts. RESULTS: The prevalence of suicidal ideation was 19.9% (95% CI: 16.7%, 23.3%), while the prevalence of suicide attempts was 9.7% (95% CI: 7.4%, 12.3%).Depression, anxiety, and post-traumatic stress disorder were significantly associated with both suicidal ideation and attempts. Sexual abuse and witnessing physical violence increased the odds of suicidal Attempts. However, physical activity was protective against suicidal ideation. CONCLUSION: The findings suggest that suicidal ideation and suicidal attempts represent important mental health concerns among adolescents and youth in post-war Tigray. Depression, anxiety, PTSD symptoms, and trauma-related experiences were significantly associated with suicidality in this study. Given the cross-sectional nature of the study, causal relationships cannot be inferred. Nevertheless, the findings underscore the need for strengthened adolescent mental health services and trauma-informed support programs in conflict-affected settings. CLINICAL TRIAL NUMBER: Not applicable. CI - (c) 2026. The Author(s). FAU - Gebrehiwot, Tesfay Gebreslassie AU - Gebrehiwot TG AD - Department of Nursing, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. gslassie2023@gmail.com. FAU - Woldemariam, Guesh Teklu AU - Woldemariam GT AD - Department of Nursing, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. FAU - Tadese, Haileslassie Tesfay AU - Tadese HT AD - Department of Nursing, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. FAU - Gebremedhin, Haftom Tesfay AU - Gebremedhin HT AD - Department of Psychiatry, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. FAU - Beraki, Mulu Ftwi AU - Beraki MF AD - Department of Midwifery, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. FAU - Berhe, Abadi Kidanemariam AU - Berhe AK AD - Department of Public Health, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. AD - Tigray Health Research Institute, Mekelle, Tigray, Ethiopia. FAU - Gebremariam, Alem AU - Gebremariam A AD - Department of Public Health, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. AD - Tigray Health Research Institute, Mekelle, Tigray, Ethiopia. FAU - Gebre, Yemane Gebremariam AU - Gebre YG AD - Department of Pediatrics, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. FAU - Alemseged, Embay Amare AU - Alemseged EA AD - Department of Public Health, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. FAU - Tesfau, Yemane Berhane AU - Tesfau YB AD - Department of Public Health, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. LA - eng PT - Journal Article DEP - 20260618 PL - England TA - BMC Psychiatry JT - BMC psychiatry JID - 100968559 SB - IM MH - Humans MH - *Suicidal Ideation MH - Ethiopia/epidemiology MH - Female MH - Adolescent MH - *Suicide, Attempted/statistics & numerical data/psychology MH - Prevalence MH - Male MH - Cross-Sectional Studies MH - Young Adult MH - Stress Disorders, Post-Traumatic/epidemiology/psychology MH - Exposure to Violence/statistics & numerical data/psychology MH - Risk Factors MH - Depression/epidemiology MH - Anxiety/epidemiology PMC - PMC13539823 OTO - NOTNLM OT - Ethiopia OT - Post-war OT - Suicidal ideation OT - Suicide attempt OT - Tigray OT - Youth COIS- Declarations. Ethical approval and consent to participate: The study was conducted after Ethical approval was secured from the Adigrat University College of Medicine and Health Sciences Health Research Ethics Review Committee (Reference Number: ADU.CMHS/HRERC/0009/2024) and permission letters were secured from the relevant education offices. Written informed consent was obtained from participants, and assent was obtained from those under 18 years of age in accordance with ethical guidelines. All participants were assured that their involvement was voluntary, would not impact their academic standing, and that the confidentiality of their data would be strictly maintained. A trained and qualified facilitator was available on-site for students to consult with any study-related questions. During the data collection process, privacy was ensured through appropriate seating arrangements and supervision procedures to maintain confidentiality and minimize peer influence during questionnaire completion. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/19 06:32 MHDA- 2026/09/03 05:37 PMCR- 2026/06/18 CRDT- 2026/06/19 00:18 PHST- 2025/12/17 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/09/03 05:37 [medline] PHST- 2026/06/19 06:32 [pubmed] PHST- 2026/06/19 00:18 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.1186/s12888-026-08284-7 [pii] AID - 8284 [pii] AID - 10.1186/s12888-026-08284-7 [doi] PST - epublish SO - BMC Psychiatry. 2026 Jun 18;26(1):687. doi: 10.1186/s12888-026-08284-7. PMID- 42316104 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20260830 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jun 18 TI - Consumption of ultra-processed foods and associated factors in Spanish children aged 8-12 years: a cross-sectional analysis within the INMA cohort study. LID - 10.1186/s12889-026-28008-6 [doi] LID - 2471 AB - BACKGROUND: The consumption of ultra-processed foods (UPF) has been associated with adverse health effects. The predictors of consumption, particularly in high-intake groups like children and adolescents, are scarcely understood. METHODS: We evaluated UPF consumption and associated factors among male and female Spanish children aged 8-12 years participating in the INMA birth cohort. We cross-sectionally analyzed data from 1565 mother-child pairs at age 8 and 314 pairs at age 12. Children's diets were assessed using validated food frequency questionnaires. UPF consumption was defined using the NOVA classification and categorized into tertiles. The associations between maternal-child characteristics and children's UPF consumption were analyzed using multinomial logistic regression to estimate relative risk ratios (RRR) and 95% confidence intervals (95%CI). RESULTS: At age 8, high UPF consumption was associated with low maternal social class, RRR = 2.22 (1.46-3.37), moderate maternal UPF consumption during pregnancy, RRR = 1.87 (1.35-2.58), high maternal UPF consumption during pregnancy, RRR = 3.47 (2.40-4.99), being male, RRR = 1.76 (1.34-2.30), and high children's TV viewing, RRR = 1.76 (1.19-2.60). At age 12, high UPF consumption was associated with high maternal UPF consumption during pregnancy, RRR = 3.09 (1.27-7.50), and high children's TV viewing, RRR = 2.34 (1.05-5.21), although it was inversely associated with maternal university education, RRR = 0.21 (0.06-0.69), and high children's physical activity, RRR = 0.43 (0.20-0.93). CONCLUSIONS: Maternal factors such as high UPF consumption during pregnancy, low social class and low education level, and low physical activity and TV watching during childhood and adolescence, were predictors of higher UPF consumption at the age of 8 and 12 years. CI - (c) 2026. The Author(s). FAU - Compan-Gabucio, Laura-Maria AU - Compan-Gabucio LM AD - Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), Sant Joan d'Alacant, Alicante, Valencian Community, 03550, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Valencian Community, Alicante, Valencian Community, 03010, Spain. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. AD - Department of Surgery and Pathology, Miguel Hernandez University, Sant Joan d'Alacant, Valencian Community, Alicante, 03550, Spain. FAU - Oncina-Canovas, Alejandro AU - Oncina-Canovas A AD - Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), Sant Joan d'Alacant, Alicante, Valencian Community, 03550, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Valencian Community, Alicante, Valencian Community, 03010, Spain. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. FAU - Torres-Collado, Laura AU - Torres-Collado L AD - Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), Sant Joan d'Alacant, Alicante, Valencian Community, 03550, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Valencian Community, Alicante, Valencian Community, 03010, Spain. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. FAU - Fernandez-Tardon, Guillermo AU - Fernandez-Tardon G AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. AD - Health Research Institute of the Principality of Asturias (ISPA), Asturias, Asturias, Principality of Asturias, Oviedo, 33011, Spain. AD - Faculty of Medicine, Community of Madrid, Universidad Nebrija, Hoyo de Manzanares, Community of Madrid, Madrid, 28015, Spain. FAU - Tardon, Adonina AU - Tardon A AD - Health Research Institute of the Principality of Asturias (ISPA), Asturias, Asturias, Principality of Asturias, Oviedo, 33011, Spain. AD - Faculty of Medicine, Community of Madrid, Universidad Nebrija, Hoyo de Manzanares, Community of Madrid, Madrid, 28015, Spain. FAU - Santa-Marina Rodriguez, Loreto AU - Santa-Marina Rodriguez L AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. FAU - Barroeta, Ziortza AU - Barroeta Z AD - Department of Preventive Medicine and Public Health, University of the Basque Country UPV/EHU, Basque Country, Leioa, Biscay, Basque Country, 48940, Spain. FAU - Vrijheid, Martine AU - Vrijheid M AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. AD - ISGlobal, Barcelona, Catalonia, 08036, Spain. AD - Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, 08005, Spain. FAU - Warkentin, Sarah AU - Warkentin S AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. AD - ISGlobal, Barcelona, Catalonia, 08036, Spain. AD - Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, 08005, Spain. FAU - Llop, Sabrina AU - Llop S AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. AD - Epidemiology and Environmental Health Joint Research Unit, FISABIO, Valencian Community, Valencian Community, Valencia, 46020, Spain. FAU - Soler-Blasco, Raquel AU - Soler-Blasco R AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. AD - Epidemiology and Environmental Health Joint Research Unit, FISABIO, Valencian Community, Valencian Community, Valencia, 46020, Spain. FAU - Ojeda-Belokon, Carolina AU - Ojeda-Belokon C AD - Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), Sant Joan d'Alacant, Alicante, Valencian Community, 03550, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Valencian Community, Alicante, Valencian Community, 03010, Spain. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. FAU - Garcia-de-la-Hera, Manuela AU - Garcia-de-la-Hera M AD - Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), Sant Joan d'Alacant, Alicante, Valencian Community, 03550, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Valencian Community, Alicante, Valencian Community, 03010, Spain. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. FAU - Vioque, Jesus AU - Vioque J AD - Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), Sant Joan d'Alacant, Alicante, Valencian Community, 03550, Spain. vioque@umh.es. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Valencian Community, Alicante, Valencian Community, 03010, Spain. vioque@umh.es. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. vioque@umh.es. AD - Department of Preventive Medicine and Public Health, University of the Basque Country UPV/EHU, Basque Country, Leioa, Biscay, Basque Country, 48940, Spain. vioque@umh.es. AD - H feminine de la Ciencia y Ginecologia, Facultad de Medicina, Avda. Ramon y Cajal s/n. 03550-Sant Joan d'Alacant, Valencian Community, Alicante, Spain. vioque@umh.es. FAU - Gonzalez-Palacios, Sandra AU - Gonzalez-Palacios S AD - Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), Sant Joan d'Alacant, Alicante, Valencian Community, 03550, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Valencian Community, Alicante, Valencian Community, 03010, Spain. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. LA - eng GR - CEX2023-0001290-S/MCIN/AEI/ 10.13039/501100011033, and support from the Generalitat de Catalunya/ GR - 2021 BP 00058/Agency for Management of University and Research Grants with a Beatriu de Pinos post-doctoral fellowship/ GR - CIGE2023/142/Generalitat Valenciana/ GR - PROMETEO-CIPROM/2024/66/Generalitat Valenciana/ GR - grant code PN22_CGE45/General Council of Official Nursing Boards of Spain and the Spanish Institute of Nursing Research/ GR - 04-541-6-2024-0153-N/"Personal Investigador en Formacion" from the "Universidad Miguel Hernandez de Elche"/ GR - PI11/01007/Instituto de Salud Carlos III/ GR - Project PI23/01568/Instituto de Salud Carlos III/ GR - ESP24PI02/2024/Consorcio Centro de Investigacion Biomedica en Red/ PT - Journal Article DEP - 20260618 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Child MH - Female MH - Spain MH - Male MH - Cross-Sectional Studies MH - *Fast Foods/statistics & numerical data MH - *Diet/statistics & numerical data MH - Cohort Studies MH - Birth Cohort PMC - PMC13523201 OTO - NOTNLM OT - Adolescents OT - Birth cohort study OT - Children OT - Determinants OT - Sex-specific OT - Ultra-Processed Foods COIS- Declarations. Ethics approval and consent to participate: All pregnant women provided written informed consent prior to their inclusion in the study. In the case of their offspring, written informed consent was obtained from their parents or legal guardians. The study was conducted in accordance with the principles of the Declaration of Helsinki and its later amendments. The study protocol was approved by the following Ethics Committees: the Clinical Research Ethics Committee of Hospital Universitario La Fe (Valencia, Spain); the Clinical Research Ethics Committee of Area Sanitaria de Gipuzkoa (Gipuzkoa, Spain); the Clinical Research Ethics Committee of Parc de Salut del Mar (Barcelona, Spain); and the Clinical Research Ethics Committee of the Principado de Asturias (Spain). The present work was additionally approved by the Clinical Research Ethics Committee of the Alicante Health Department - Hospital General (Ref.: PI2024-087, June 19, 2024). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/19 06:33 MHDA- 2026/08/28 11:46 PMCR- 2026/06/18 CRDT- 2026/06/19 00:07 PHST- 2026/03/20 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/08/28 11:46 [medline] PHST- 2026/06/19 06:33 [pubmed] PHST- 2026/06/19 00:07 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.1186/s12889-026-28008-6 [pii] AID - 28008 [pii] AID - 10.1186/s12889-026-28008-6 [doi] PST - epublish SO - BMC Public Health. 2026 Jun 18;26(1):2471. doi: 10.1186/s12889-026-28008-6. PMID- 42316044 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260829 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jun 18 TI - Machine learning to improve the prediction of Large for Gestational Age (LGA) neonates: a cohort study. LID - 10.1186/s12884-026-09411-8 [doi] LID - 956 AB - BACKGROUND: Prediction of Large for Gestational Age (LGA) risk is important as it can enable earlier, more effective interventions, and avoid or mitigate cumulative injury to both mother and baby at the time of delivery. The goal of this research is to improve the prediction of LGA using machine learning (ML) models and variables that are widely available as that allow for broad intervention in late pregnancy and during delivery. METHODS: An improved prediction of LGA was achieved using twelve ML models with hyperparameter optimization. Also, to improve the LGA prediction a data augmentation method was employed in the training set. Additionally, improvement in LGA prediction was obtained with four variable selection methods employed to identify the most significant variables. To rank the best models on the validation set after training, the Area under the Receiver Operating Characteristic Curve (AUROC) was used. Finally, to assess the generalization performance, the best models were evaluated on the test set. RESULTS: Our method enabled us to identify several models with high sensitivity and specificity. The best models included those that achieved a sensitivity of 0.84, a specificity of 0.84, an accuracy of 0.84, and AUCROC 0.83, requiring 14 variables. Another model reached an accuracy of 0.87, a sensitivity of 0.71, and a specificity of 0.90 with an AUCROC of 0.83 (14 variables). Additionally, a model with a sensitivity of 0.58, the same as that described by Hadlock et al. [1] for ultrasound, required 10 variables, and reached an accuracy of 0.91, a specificity of 0.97, and an AUCROC of 0.86. Both models included maternal BMI (body mass index), First Control, Maternal Weight, BMI Last Control, and EFW (estimated fetal weight) as the most important variables. CONCLUSIONS: The main contributions of our study include the prediction of LGA using data obtained from standard clinical evaluations during prenatal care, as well as the development ML models, tuning the hyperparameters to improve prediction results, thus achieving high levels of sensitivity and specificity. To achieve optimal LGA prediction outcomes across different models, a data augmentation approach is introduced, an important improvement in LGA prediction over using only Hadlock's ultrasound formula. CI - (c) 2026. The Author(s). FAU - Cubillos, Gabriel AU - Cubillos G AD - Department of Electrical Engineering, Universidad de Chile, Av. Tupper 2007, Santiago, 8370451, Chile. AD - IMPACT, Center of Interventional Medicine for Precision and Advanced Cellular Therapy, Santiago, Chile. FAU - Monckeberg, Max AU - Monckeberg M AD - Department of Obstetrics and Gynecology and Laboratory of Reproductive Biology, Faculty of Medicine, Universidad de los Andes, San Carlos de Apoquindo 2200, Santiago, 7620001, Chile. FAU - Plaza, Alejandra AU - Plaza A AD - Department of Obstetrics and Gynecology and Laboratory of Reproductive Biology, Faculty of Medicine, Universidad de los Andes, San Carlos de Apoquindo 2200, Santiago, 7620001, Chile. FAU - Morgan, Maria AU - Morgan M AD - Department of Obstetrics and Gynecology and Laboratory of Reproductive Biology, Faculty of Medicine, Universidad de los Andes, San Carlos de Apoquindo 2200, Santiago, 7620001, Chile. FAU - Estevez, Pablo A AU - Estevez PA AD - Department of Electrical Engineering, Universidad de Chile, Av. Tupper 2007, Santiago, 8370451, Chile. AD - IMPACT, Center of Interventional Medicine for Precision and Advanced Cellular Therapy, Santiago, Chile. FAU - Choolani, Mahesh AU - Choolani M AD - Department of Obstetrics and Gynaecology, NUS Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore. FAU - Kemp, Matthew W AU - Kemp MW AD - Department of Obstetrics and Gynaecology, NUS Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore. FAU - Li, Sarah W L AU - Li SWL AD - Department of Obstetrics and Gynaecology, NUS Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore. FAU - Illanes, Sebastian E AU - Illanes SE AD - IMPACT, Center of Interventional Medicine for Precision and Advanced Cellular Therapy, Santiago, Chile. sillanes@uandes.cl. AD - Department of Obstetrics and Gynecology and Laboratory of Reproductive Biology, Faculty of Medicine, Universidad de los Andes, San Carlos de Apoquindo 2200, Santiago, 7620001, Chile. sillanes@uandes.cl. AD - Department of Obstetrics and Gynaecology, NUS Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore. sillanes@uandes.cl. FAU - Perez, Claudio A AU - Perez CA AD - Department of Electrical Engineering, Universidad de Chile, Av. Tupper 2007, Santiago, 8370451, Chile. clperez@ing.uchile.cl. AD - IMPACT, Center of Interventional Medicine for Precision and Advanced Cellular Therapy, Santiago, Chile. clperez@ing.uchile.cl. LA - eng GR - IMPACT, #FB210024/Agencia Nacional de Investigacion y Desarrollo (ANID)/ PT - Journal Article DEP - 20260618 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Infant, Large for Gestational Age MH - Predictive Learning Models MH - Infant, Newborn MH - *Machine Learning MH - Prediction Algorithms MH - ROC Curve MH - Sensitivity and Specificity MH - Gestational Age MH - Cohort Studies MH - Area Under Curve MH - Adult MH - Classification Algorithms MH - Ultrasonography, Prenatal MH - *Fetal Macrosomia/diagnosis PMC - PMC13520273 OTO - NOTNLM OT - Commonly accessible variables OT - Data augmentation techniques OT - LGA prediction OT - Large for Gestational Age (LGA) OT - Machine learning algorithms OT - Ultrasound COIS- Declarations. Ethics approval and consent to participate: The data usage was approved by the by the institutional review board (IRB) of Hospital Parroquial de San Bernardo, Santiago, Chile, who determined that the research does not involve human subjects because the study uses previously collected, de-identified data. The "Comite de Etica del Hospital Parroquial de San Bernardo" waived the need for informed consent. All methods were carried out in accordance with relevant guidelines and regulations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/19 06:32 MHDA- 2026/08/27 05:35 PMCR- 2026/06/18 CRDT- 2026/06/19 00:05 PHST- 2024/09/17 00:00 [received] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/08/27 05:35 [medline] PHST- 2026/06/19 06:32 [pubmed] PHST- 2026/06/19 00:05 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.1186/s12884-026-09411-8 [pii] AID - 9411 [pii] AID - 10.1186/s12884-026-09411-8 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jun 18;26(1):956. doi: 10.1186/s12884-026-09411-8. PMID- 42315960 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20261008 IS - 1476-5640 (Electronic) IS - 0954-3007 (Linking) VI - 80 IP - 9 DP - 2026 Sep TI - Comparative machine learning modeling of resting energy expenditure estimation in mechanically ventilated children after cardiac surgery. PG - 949-957 LID - 10.1038/s41430-026-01775-6 [doi] AB - OBJECTIVE: Nutrition status is vital for children's recovery following cardiac surgery, with substantial inter-individual variability in metabolic demands. We aimed to develop machine learning (ML) models of postoperative resting energy expenditure (REE) by analysing the influential factors. METHODS: We retrospectively analyzed children who underwent indirect calorimetry (IC) for valid REE measurements within 4 to 24 h after cardiac surgery between January 2021 and December 2022 at our center. Nine ML algorithms were trained to predict REE. Bland-Altman analysis assessed agreement with measured REE, and SHAP was used for population-level interpretation and a representative patient case. RESULTS: A total of 278 mechanically ventilated children were analyzed. REE measured by IC ranged from 387 to 2642 kcal/d (715 [550, 964]). The root mean square error (RMSE) of the ML models ranged from 226 (95% CI: 184-267) to 281 (95% CI: 225-344) kcal/d, while the range for conventional equations was 249 (95% CI: 215-287) to 282 (95% CI: 252-315) kcal/d. Regularized linear models achieved the highest R(2) of 0.64 (95% CI: 0.49-0.76). The top 10 most important variables associated with REE in the optimal model are weight, age, height, preoperative serum albumin, preoperative CK-MB, vasoactive inotropic score (VIS), CPB time, postoperative LVEDD Z-score, gender, and postoperative NT-proBNP. CONCLUSIONS: This study developed ML models to predict REE in children after cardiac surgery, with some models outperforming conventional equations. These findings highlight the potential of machine learning to optimize postoperative nutritional management by accurately capturing the non-linear metabolic response to surgical stress. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Li, Chenyu AU - Li C AUID- ORCID: 0009-0002-0211-0441 AD - Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Zhu, Zhiyuan AU - Zhu Z AD - Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Wang, Shilin AU - Wang S AD - Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Li, Chao AU - Li C AD - Capital Center for Children's Health, Capital Institute of Pediatrics, Capital Medical University, Beijing, China. FAU - Lu, Zhongyuan AU - Lu Z AD - Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Chen, Qinnan AU - Chen Q AD - Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Wang, Xu AU - Wang X AUID- ORCID: 0000-0002-4887-3367 AD - Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. fwpicu@163.com. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260618 PL - England TA - Eur J Clin Nutr JT - European journal of clinical nutrition JID - 8804070 SB - IM MH - Humans MH - Female MH - *Machine Learning MH - *Respiration, Artificial MH - Male MH - *Cardiac Surgical Procedures MH - Retrospective Studies MH - Calorimetry, Indirect MH - Child, Preschool MH - Infant MH - *Basal Metabolism/physiology MH - Postoperative Period MH - Child MH - Nutritional Status MH - Predictive Learning Models MH - *Energy Metabolism COIS- Competing interests: The authors declare no competing interests. Ethical approval: This study was approved by the Ethics Committee of the Fuwai Hospital in 2022 (ID: 2022-1859). This study complied with the ethical principles laid out in the Helsinki Declaration of 1975, as revised in 2008. Informed consent: In this study, the ethics committee approved the waiver of informed consent. EDAT- 2026/06/19 00:36 MHDA- 2026/09/10 05:37 CRDT- 2026/06/18 23:34 PHST- 2025/08/12 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/05/01 00:00 [revised] PHST- 2026/09/10 05:37 [medline] PHST- 2026/06/19 00:36 [pubmed] PHST- 2026/06/18 23:34 [entrez] AID - 10.1038/s41430-026-01775-6 [pii] AID - 10.1038/s41430-026-01775-6 [doi] PST - ppublish SO - Eur J Clin Nutr. 2026 Sep;80(9):949-957. doi: 10.1038/s41430-026-01775-6. Epub 2026 Jun 18. PMID- 42315145 OWN - NLM STAT- Publisher LR - 20260618 IS - 1741-2889 (Electronic) IS - 1367-4935 (Linking) DP - 2026 Jun 18 TI - Validation of a parent-report version of the Emotional Eating Scale Adapted for Children and Adolescents Short-Form in American mothers. PG - 13674935261459838 LID - 10.1177/13674935261459838 [doi] AB - Emotional eating is associated with negative outcomes in children, including elevated weight status and disordered eating. The current study assessed the preliminary psychometric properties of a 10-item parent-report version of the Emotional Eating Scale Adapted for Children (EES-C) Short-Form. Participants were 324 mothers of children ages 5-12 years. The parent-report version of the EES-C Short-Form and the Child Feeding Questionnaire were administered to mothers in the United States online. Cronbach's alpha for the parent-report version of the EES-C-Short-Form was in the excellent range (alpha = .94). Mothers reported significantly higher levels of emotional eating in overweight/obese children than healthy weight children eating (effect size = 0.45, p < .001). Maternal reports of their child's emotional eating on the EES-C-Short-Form were associated with maternal concern about their child's weight (r = .285; 95% confidence interval = .18-.39), restricted eating (r = .238; 95% confidence interval = .13-.35), and monitoring of their child's food intake (r = .136; 95% confidence interval = .02-.25) on the Child Feeding Questionnaire, supporting convergent validity. A unidimensional model produced a good fit (chi(2) (35) = 70.31, p = 0.00, CFI = .999, SRMR = .036). Taken as a whole, this study provides preliminary support for the reliability and validity of the parent version of the EES-C Short-Form. FAU - Summers, Emma AU - Summers E AUID- ORCID: 0009-0003-2562-5189 AD - Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA. RINGGOLD: 14643 FAU - Limbers, Christine A AU - Limbers CA AUID- ORCID: 0000-0002-4880-1865 AD - Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA. RINGGOLD: 14643 LA - eng PT - Journal Article DEP - 20260618 PL - England TA - J Child Health Care JT - Journal of child health care : for professionals working with children in the hospital and community JID - 9806360 SB - IM OTO - NOTNLM OT - child OT - emotional eating OT - parents OT - psychometrics EDAT- 2026/06/19 00:36 MHDA- 2026/06/19 00:36 CRDT- 2026/06/18 19:53 PHST- 2026/06/19 00:36 [medline] PHST- 2026/06/19 00:36 [pubmed] PHST- 2026/06/18 19:53 [entrez] AID - 10.1177/13674935261459838 [doi] PST - aheadofprint SO - J Child Health Care. 2026 Jun 18:13674935261459838. doi: 10.1177/13674935261459838. PMID- 42313740 OWN - NLM STAT- MEDLINE DCOM- 20260618 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 6 DP - 2026 TI - The validity and reliability of a biometrically accurate, photorealistic set of young adult body size scales based on 3D scans of White Europeans. PG - e0351658 LID - 10.1371/journal.pone.0351658 [doi] LID - e0351658 AB - Young adults are a high-risk group for weight-related health problems but are often overlooked in weight management intervention design. Validated visual tools that accurately depict body size are needed to improve communication and intervention strategies. This study validated innovative, photo-realistic, gender-specific body size scales of young adults (aged 18), created from 3D scans to depict systematic changes in adiposity. A total of 110 young adults (aged 18-25) completed two behavioural tasks: (1) estimating the relative size of the bodies and (2) ranking them in ascending order of weight. To assess reliability, participants repeated the tasks three days later. Participants accurately estimated relative body sizes and ranked the images in line with the systematic BMI changes across the scales. Test-retest analyses showed good to excellent reliability for both tasks. The young adult body size scales are anthropometrically accurate, reliable, and valid tools for body size estimation tasks. They provide a robust resource for research, clinical communication, and intervention design focused on young adults. CI - Copyright: (c) 2026 Ridley et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Ridley, Bethany J AU - Ridley BJ AD - Department of Psychology, Northumbria University, Newcastle upon Tyne, United Kingdom. FAU - Cornelissen, Piers L AU - Cornelissen PL AD - Department of Psychology, Northumbria University, Newcastle upon Tyne, United Kingdom. FAU - Kramer, Robin S S AU - Kramer RSS AD - School of Psychology, Sport Science and Wellbeing, University of Lincoln, Lincoln, United Kingdom. FAU - Maalin, Nadia AU - Maalin N AUID- ORCID: 0000-0001-7055-1658 AD - Department of Psychology and Counselling, Birmingham City University, Birmingham, United Kingdom. FAU - Mohamed, Sophie AU - Mohamed S AD - Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, United Kingdom. FAU - Tovee, Martin J AU - Tovee MJ AUID- ORCID: 0000-0001-9642-4462 AD - Department of Psychology, Northumbria University, Newcastle upon Tyne, United Kingdom. LA - eng PT - Journal Article PT - Validation Study DEP - 20260618 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - Male MH - *Body Size MH - Young Adult MH - Adult MH - Adolescent MH - Reproducibility of Results MH - *Imaging, Three-Dimensional/methods MH - White People MH - Body Mass Index MH - *Anthropometry/methods PMC - PMC13278476 COIS- The authors have declared that no competing interests exist. EDAT- 2026/06/18 18:33 MHDA- 2026/06/18 18:34 PMCR- 2026/06/18 CRDT- 2026/06/18 13:33 PHST- 2025/10/23 00:00 [received] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/06/18 18:34 [medline] PHST- 2026/06/18 18:33 [pubmed] PHST- 2026/06/18 13:33 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - PONE-D-25-54538 [pii] AID - 10.1371/journal.pone.0351658 [doi] PST - epublish SO - PLoS One. 2026 Jun 18;21(6):e0351658. doi: 10.1371/journal.pone.0351658. eCollection 2026. PMID- 42312671 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260910 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2026 Jun 18 TI - Development and validation of the Brazilian Dietary Guidelines Adherence Score (BraScore): a novel index to assess the adherence to the Dietary Guidelines for the Brazilian Population. PG - e141 LID - 10.1017/S1368980026102936 [doi] LID - e141 AB - OBJECTIVE: We aimed to describe the development and evaluation of the Brazilian Dietary Guidelines Adherence Score (BraScore). DESIGN: The process comprised multiple steps: defining guiding principles, identifying food components, setting scoring cut-off points and assessing validity and reliability. SETTING: Nationally representative sample of the Brazilian population. PARTICIPANTS: 46 164 Brazilians aged >/= 10 years. RESULTS: The BraScore has ten components: to be consumed (legumes; fruits; vegetables and diversity), to be limited (red meat; other animal-based foods; processed foods; table sugar and cooking salt) and to be avoided (ultra-processed foods). Scores range from 0 to 100, with higher values indicating greater adherence to the Dietary Guidelines. Analyses showed a weak correlation with energy intake (coefficient: -0.12) and substantial variability among individuals (1st percentile: 20.5; 99th: 77.7). Scree plot analysis revealed multidimensionality, indicating four distinct patterns. The scores differentiated population groups (older adults and rural residents had higher scores) and were high for diets developed by nutritionists (84.6-97.6 points). The reliability analysis yielded a coefficient of 0.6, suggesting acceptable internal consistency. CONCLUSIONS: The BraScore is a valid and reliable tool to assess adherence to the Dietary Guidelines for the Brazilian Population. FAU - Souza, Thays Nascimento AU - Souza TN AUID- ORCID: 0000-0001-5405-5398 AD - Department of Nutrition, https://ror.org/036rp1748University of Sao Paulo, Brazil. AD - https://ror.org/036rp1748Centre for Epidemiological Research in Nutrition and Health at the University of Sao Paulo (NUPENS/USP), Brazil. AD - Programa de Pos Graduacao em Nutricao em Saude Publica, Faculdade de Saude Publica, https://ror.org/036rp1748Universidade de Sao Paulo, Brazil. FAU - Gabe, Kamila Tiemann AU - Gabe KT AUID- ORCID: 0000-0001-5138-9552 AD - Department of Nutrition, https://ror.org/036rp1748University of Sao Paulo, Brazil. AD - https://ror.org/036rp1748Centre for Epidemiological Research in Nutrition and Health at the University of Sao Paulo (NUPENS/USP), Brazil. AD - Programa de Pos Graduacao em Nutricao em Saude Publica, Faculdade de Saude Publica, https://ror.org/036rp1748Universidade de Sao Paulo, Brazil. FAU - Cacau, Leandro Teixeira AU - Cacau LT AUID- ORCID: 0000-0003-1681-5960 AD - Department of Nutrition, https://ror.org/036rp1748University of Sao Paulo, Brazil. AD - https://ror.org/036rp1748Centre for Epidemiological Research in Nutrition and Health at the University of Sao Paulo (NUPENS/USP), Brazil. AD - Programa de Pos Graduacao em Nutricao em Saude Publica, Faculdade de Saude Publica, https://ror.org/036rp1748Universidade de Sao Paulo, Brazil. FAU - Carneiro, Leticia Barroso Vertulli AU - Carneiro LBV AUID- ORCID: 0000-0003-0832-2293 AD - Universidade Federal do Rio de Janeiro, Instituto de Estudos em Saude Coletiva, Brazil. FAU - Lassale, Camille AU - Lassale C AD - Barcelona Institute for Global Health, Spain. AD - Pompeu Fabra University, Spain. AD - Instituto de Salud Carlos III, Spain. FAU - Levy, Renata Bertazzi AU - Levy RB AUID- ORCID: 0000-0001-5388-7002 AD - https://ror.org/036rp1748Centre for Epidemiological Research in Nutrition and Health at the University of Sao Paulo (NUPENS/USP), Brazil. AD - Department of Preventive Medicine, University of Sao Paulo, Brazil. AD - Institute for Biomedical Research of Salamanca, Spain. FAU - Castro, Ines Rugani Ribeiro de AU - Castro IRR AD - Universidade Estadual do Rio de Janeiro, Brazil. FAU - Louzada, Maria Laura da Costa AU - Louzada MLDC AD - Department of Nutrition, https://ror.org/036rp1748University of Sao Paulo, Brazil. AD - https://ror.org/036rp1748Centre for Epidemiological Research in Nutrition and Health at the University of Sao Paulo (NUPENS/USP), Brazil. AD - Programa de Pos Graduacao em Nutricao em Saude Publica, Faculdade de Saude Publica, https://ror.org/036rp1748Universidade de Sao Paulo, Brazil. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20260618 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Brazil MH - *Nutrition Policy MH - Female MH - Adult MH - Reproducibility of Results MH - Middle Aged MH - Male MH - Child MH - *Diet/standards/statistics & numerical data MH - Young Adult MH - Adolescent MH - *Guideline Adherence/statistics & numerical data MH - Aged MH - *Diet Surveys MH - Energy Intake PMC - PMC13434578 OTO - NOTNLM OT - Diet index OT - Food guide OT - Healthy eating indices OT - Nutritional epidemiology OT - Ultra-processed foods COIS- There are no conflicts of interest. EDAT- 2026/06/18 12:33 MHDA- 2026/07/11 01:09 PMCR- 2026/06/18 CRDT- 2026/06/18 07:34 PHST- 2026/07/11 01:09 [medline] PHST- 2026/06/18 12:33 [pubmed] PHST- 2026/06/18 07:34 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - S1368980026102936 [pii] AID - 10.1017/S1368980026102936 [doi] PST - epublish SO - Public Health Nutr. 2026 Jun 18;29(1):e141. doi: 10.1017/S1368980026102936. PMID- 42312484 OWN - NLM STAT- Publisher LR - 20260618 IS - 1557-1246 (Electronic) IS - 1087-0547 (Linking) DP - 2026 Jun 18 TI - Association of Inflammatory Biomarkers With ADHD and Moderating Effect of Leisure-Time Physical Activity in Adolescents: A Cross-Sectional Study Based on NHANES. PG - 10870547261458103 LID - 10.1177/10870547261458103 [doi] AB - INTRODUCTION: Research findings on specific inflammatory markers (e.g., CRP) in ADHD show considerable heterogeneity. Meanwhile, the potential moderating role of leisure-time physical activity (LTPA) in this relationship is underexplored. METHODS: Based on data from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2004, 4,817 adolescents aged 12 to 19 were included. This study used logistic regression analysis and restricted cubic splines (RCS) to explore the association between inflammatory biomarkers and ADHD. Interactive analyses were performed to assess the moderating effect of LTPA on this relationship. Furthermore, subgroup analyses were conducted to validate the robustness of the observed effects. RESULTS: After adjusting for all confounding factors, each 1 mg/L increment in C-reactive protein (CRP) was associated with a 9% higher ADHD risk (OR = 1.09, 95% CI [1.01, 1.18]). The chronic low-grade inflammation (CLGI) group exhibited a 57% higher risk of ADHD (OR = 1.57, 95% CI [1.14, 2.15]) compared to the non-GLGI group. The non-linear analysis further revealed that the risk of ADHD reached its peak when CRP was 2.75 mg/L (OR = 1.89, 95% CI [1.39, 2.57]). Compared with the group engaging in less than 60 min of LTPA daily, the association between ADHD and CRP was moderated in the "LTPA >/=60 min/day" group (p for interaction = .04). CONCLUSIONS: Elevated CRP levels are positively associated with ADHD. More than 60 min/day LTPA may moderate the association between CRP and the risk of ADHD. FAU - Pan, Keyu AU - Pan K AUID- ORCID: 0009-0004-9716-7970 AD - School of Exercise and Health, Shanghai University of Sport, China. FAU - Jin, Shanru AU - Jin S AD - School of Exercise and Health, Shanghai University of Sport, China. FAU - Gao, Xiang AU - Gao X AD - School of Exercise and Health, Shanghai University of Sport, China. FAU - He, Changshuang AU - He C AD - School of Exercise and Health, Shanghai University of Sport, China. FAU - Shi, Beibei AU - Shi B AD - School of Exercise and Health, Shanghai University of Sport, China. AD - School of Physical Education, Shandong University, China. FAU - Zhang, Meng AU - Zhang M AD - School of Exercise and Health, Shanghai University of Sport, China. FAU - Wei, Yiting AU - Wei Y AD - School of Exercise and Health, Shanghai University of Sport, China. FAU - Quan, Minghui AU - Quan M AD - School of Exercise and Health, Shanghai University of Sport, China. LA - eng PT - Journal Article DEP - 20260618 PL - United States TA - J Atten Disord JT - Journal of attention disorders JID - 9615686 SB - IM OTO - NOTNLM OT - ADHD OT - CLGI OT - CRP OT - LTPA OT - inflammatory biomarkers EDAT- 2026/06/18 06:31 MHDA- 2026/06/18 06:31 CRDT- 2026/06/18 05:53 PHST- 2026/06/18 06:31 [medline] PHST- 2026/06/18 06:31 [pubmed] PHST- 2026/06/18 05:53 [entrez] AID - 10.1177/10870547261458103 [doi] PST - aheadofprint SO - J Atten Disord. 2026 Jun 18:10870547261458103. doi: 10.1177/10870547261458103. PMID- 42311940 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260618 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Comparing food literacy by grade, sex, and food education exposure: construct validation of the food literacy BITE scale. PG - 1819437 LID - 10.3389/fnut.2026.1819437 [doi] LID - 1819437 AB - BACKGROUND: Food literacy provides a framework for understanding dietary behaviors in children and can inform priorities for and evaluate the effectiveness of food education interventions. The 4-dimension Food Literacy BITE scale is built on a child-centered food literacy framework and has been structurally validated in U.S. elementary schoolchildren. We conducted additional validity testing to assess the tool's generalizability, ability to differentiate mean food literacy by grade, sex, and food education exposure, and the association of food literacy score with food group consumption frequencies. MATERIALS AND METHODS: We administered the Food Literacy BITE scale and food frequency questionnaires to n = 690 4 (th) and 5 (th) -grade students from 10 elementary schools in Washington, DC, and Kentucky (52.5% 4 (th) grade, 55.8% 4+ years of food education, 52.8% girls). Stepwise series of multiple-group confirmatory factor analysis models assessed measurement invariance by grade, sex, and school-level food education history. We examined group differences in overall food literacy score and dimension scores using latent means and used multilevel modeling for the food education exposure analysis to account for clustering within schools. We used weighted regression with robust standard errors to investigate associations between food literacy scores and food group consumption frequencies, aggregated by school and grade (n = 20). RESULTS: Item interpretation was consistent across groups, with full scalar invariance established by grade and partial scalar invariance by sex and food education history (4+years vs. new/none). Girls scored higher than boys in the "confidence in everyday food skills" dimension (p = 0.03). Mean food literacy was higher in the group from schools offering 4+ years of experiential food education (p = 0.03), driven by higher scores in the "valuing shared food experiences" (p = 0.02) and "food systems and nutrition knowledge" (p = 0.04) dimensions. In the multilevel models, only the difference in "valuing shared food experiences" remained significant. CONCLUSION: Results support generalizable use of the Food Literacy BITE scale in the U.S. and areas with similar food practices and environments. The tool's ability to differentiate between food education exposure history suggests it may be useful in identifying best practices for food education interventions targeting late childhood. CI - Copyright (c) 2026 St. Pierre, Bingenheimer, van Dam and Sacheck. FAU - St Pierre, Christine AU - St Pierre C AD - Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC, United States. FAU - Bingenheimer, Jeffrey B AU - Bingenheimer JB AD - Department of Prevention and Community Health, Milken Institute School of Public Health, The George Washington University, Washington, DC, United States. FAU - van Dam, Rob M AU - van Dam RM AD - Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC, United States. FAU - Sacheck, Jennifer M AU - Sacheck JM AD - Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC, United States. AD - Department of Behavioral and Social Sciences, School of Public Health, Brown University, Providence, RI, United States. LA - eng PT - Journal Article DEP - 20260602 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13268878 OTO - NOTNLM OT - children OT - food education OT - food literacy OT - measurement properties OT - scale development COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/18 06:32 MHDA- 2026/06/18 06:33 PMCR- 2026/06/02 CRDT- 2026/06/18 04:42 PHST- 2026/02/27 00:00 [received] PHST- 2026/04/30 00:00 [revised] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/06/18 06:33 [medline] PHST- 2026/06/18 06:32 [pubmed] PHST- 2026/06/18 04:42 [entrez] PHST- 2026/06/02 00:00 [pmc-release] AID - 10.3389/fnut.2026.1819437 [doi] PST - epublish SO - Front Nutr. 2026 Jun 2;13:1819437. doi: 10.3389/fnut.2026.1819437. eCollection 2026. PMID- 42310262 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260910 IS - 1573-6628 (Electronic) IS - 1092-7875 (Print) IS - 1092-7875 (Linking) VI - 30 IP - 8 DP - 2026 Aug TI - Baby-Feed Pilot Trial for Improving Diet and Weight Gain in Infants and Toddlers. PG - 1017-1027 LID - 10.1007/s10995-026-04282-z [doi] AB - OBJECTIVE: To pilot test the initial efficacy of the Baby-Feed website for improving infant diet quality (main outcome) and weight gain (exploratory outcome) compared to usual care. METHODS: This was a 3-month randomized clinical trial, in which two healthcare providers and 50 caregivers of healthy-term infants (4-12 months) in a community health center were recruited. Participants were randomized to usual care or access to the Baby-Feed website, which assesses infants' diets, provides automated results, and delivers feedback. Measures were assessed at baseline and at the end of the study: diet quality from a validated infant food frequency questionnaire (FFQ), self-reported weight/length to calculate rate of weight gain, and a validated self-efficacy questionnaire. Changes were compared using analysis of covariance or Chi-square/Fisher's Exact test. RESULTS: Baseline characteristics were similar between groups (n = 25 intervention; n = 25 control). Most caregivers were mothers (92%) and Hispanic (86%). Change in total diet quality scores was higher in the intervention (-2.95 +/- 6.53) vs. controls (-7.69 +/- 7.84; p = 0.031). Healthy weight gain was higher in the intervention group (n = 21, 95%) vs. controls (n = 14, 58%; p = 0.006). Changes in the self-efficacy score for promoting healthy foods were associated with changes in the fruit score (r = 0.46; p = 0.03), and changes in the self-efficacy score for limiting unhealthy foods were associated with changes in the juice score (r = 0.45; p = 0.04) only in the intervention group. CONCLUSIONS: Using Baby-Feed for 3 months improved diet quality and the rate of weight gain compared with controls in this small and short pilot trial. A larger, longer trial with a more diverse population is needed to confirm the results. TRIAL REGISTRY: https://clinicaltrials.gov/ : NCT05062824. CI - (c) 2026. The Author(s). FAU - Bolton, Jennifer AU - Bolton J AUID- ORCID: 0000-0002-8324-9113 AD - Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, 11200 SW 8th Street AHC5, Miami, FL, 33199, USA. FAU - Wang, Wenjia AU - Wang W AUID- ORCID: 0000-0002-1967-0405 AD - Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, 11200 SW 8th Street AHC5, Miami, FL, 33199, USA. AD - Vertically Integrated Projects, Knight Foundation School of Computing and Information Sciences, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA. FAU - Coccia, Catherine AU - Coccia C AUID- ORCID: 0000-0002-8086-4479 AD - Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, 11200 SW 8th Street AHC5, Miami, FL, 33199, USA. FAU - Narayanan, Vijaya AU - Narayanan V AUID- ORCID: 0009-0003-6685-1430 AD - Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, 11200 SW 8th Street AHC5, Miami, FL, 33199, USA. FAU - Varella, Marcia AU - Varella M AUID- ORCID: 0000-0003-2626-8825 AD - Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street AHC1, Miami, FL, 33199, USA. FAU - Hannan, Jean AU - Hannan J AUID- ORCID: 0000-0003-3740-620X AD - Nicole Wertheim College of Nursing & Health Sciences, Florida International University, 11200 SW 8th Street AHC5, Miami, FL, 33199, USA. FAU - Palacios, Cristina AU - Palacios C AUID- ORCID: 0000-0001-9437-0376 AD - Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, 11200 SW 8th Street AHC5, Miami, FL, 33199, USA. crpalaci@fiu.edu. AD - Department of Dietetics and Nutrition in the Robert Stempel College of Public Health & Social Work, Florida International University, 11200 SW 8th Street, AHC 5-313, Miami, 33199, FL, USA. crpalaci@fiu.edu. LA - eng SI - ClinicalTrials.gov/NCT05062824 GR - Children's Trust/Children's Trust/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20260618 PL - United States TA - Matern Child Health J JT - Maternal and child health journal JID - 9715672 SB - IM MH - Humans MH - Infant MH - *Weight Gain/physiology MH - Pilot Projects MH - Female MH - Male MH - *Diet/standards MH - *Infant Food MH - Surveys and Questionnaires MH - Infant Nutritional Physiological Phenomena MH - Internet PMC - PMC13503433 OTO - NOTNLM OT - Diet quality OT - Infant OT - Intervention OT - Website OT - Weight gain COIS- Declarations. Competing Interests: The authors have not disclosed any competing interests. Ethical Approval: Study procedures were approved by the IRB at Florida International University (Protocol Number: 20-0498). Data Sharing: Deidentified individual participant data (including the data dictionary) underlying the results reported in this study will be made available upon reasonable request to the corresponding author. EDAT- 2026/06/18 00:31 MHDA- 2026/08/25 05:34 PMCR- 2026/06/18 CRDT- 2026/06/17 23:26 PHST- 2025/03/08 00:00 [received] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/08/25 05:34 [medline] PHST- 2026/06/18 00:31 [pubmed] PHST- 2026/06/17 23:26 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.1007/s10995-026-04282-z [pii] AID - 4282 [pii] AID - 10.1007/s10995-026-04282-z [doi] PST - ppublish SO - Matern Child Health J. 2026 Aug;30(8):1017-1027. doi: 10.1007/s10995-026-04282-z. Epub 2026 Jun 18. PMID- 42309663 OWN - NLM STAT- MEDLINE DCOM- 20260617 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 6 DP - 2026 Jun 17 TI - Measuring multisector nutrition and health intervention coverage using composite coverage analysis methods: a scoping review and methodological guidance. PG - e111298 LID - 10.1136/bmjopen-2025-111298 [doi] LID - e111298 AB - OBJECTIVES: Composite indices provide an opportunity to measure the reach of multisector strategies as countries progress towards Sustainable Development Goals and the achievement of nutrition, health and other sectoral targets. Composite measures allow for the measurement of nutrition and health intervention coverage across sectors and can be used to benchmark progress, track nutrition goals and assess inequities of multisector nutrition interventions. Of the many composite indices in use to measure health and nutrition intervention coverage and population status as a means of assessing progress in achieving health and nutrition targets, few have been previously documented in the nutrition and health literature, nor have these indicators been described in detail. This scoping review aimed to identify composite coverage indices that capture nutrition and health intervention coverage or status, summarise their estimation methodologies and validation approaches and evaluate their strengths and weaknesses. DESIGN: Scoping review conducted in accordance with the Joanna Briggs Institute Reviewer Manual following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) verification list. DATA SOURCES: PubMed, EMBASE, Scopus, Google Scholar and Global Health registries were searched from 1980 to 3 March 2026. ELIGIBILITY CRITERIA: We included studies of any design that described, used or developed a composite measurement of health or nutrition intervention coverage or status. DATA EXTRACTION AND SYNTHESIS: One reviewer screened the titles and abstracts and full text using Covidence and abstracted data from each article using Microsoft Excel using standardised methods. RESULTS: We retrieved and screened a total of 7120 records of which 154 articles were included. We identified a total of 56 unique indices (25 universal healthcare coverage; 14 reproductive, maternal, newborn, child health (RMNCH) coverage; 10 nutritional status, food security or nutrition intervention coverage; 6 health service coverage and 1 combined universal healthcare, health risk factors and nutrition coverage measure). We identified three major formula construction methodologies: normative (n=34), statistical (n=13) and participatory (n=10). Together, the indices employed six different aggregation methods: weighted linear mean (n=28), geometric mean (n=13), linear mean (n=9), random-effects meta-analysis (n=6), summation (n=2) and weighted geometric mean (n=1). More than one third of the indices identified have not been validated in the literature (n=21). CONCLUSIONS: Our review identified a significant gap in composite nutrition intervention coverage index availability, methodological frameworks for index design and index validation. There is a need for additional resources for guiding policy and programme actors to develop validated, fit for purpose composite nutrition-specific and nutrition-sensitive coverage indices. We propose that a framework be developed for stakeholders to guide composite index construction for multisectoral nutrition intervention coverage measurement. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Morrison, Taylor AU - Morrison T AUID- ORCID: 0009-0006-5346-5946 AD - Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA tmorri45@alumni.jh.edu. FAU - Akseer, Nadia AU - Akseer N AUID- ORCID: 0000-0002-3802-7298 AD - Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Heidkamp, Rebecca AU - Heidkamp R AD - Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Maiga, Abdoulaye AU - Maiga A AD - Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Tasic, Hana AU - Tasic H AUID- ORCID: 0009-0006-0589-3612 AD - Modern Scientist Global, St Catharines, Ontario, Canada. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260617 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Nutritional Status PMC - PMC13288883 OTO - NOTNLM OT - Health Equity OT - Health Services Accessibility OT - Health policy COIS- Competing interests: None declared. EDAT- 2026/06/18 00:32 MHDA- 2026/06/18 00:33 PMCR- 2026/06/17 CRDT- 2026/06/17 21:12 PHST- 2026/06/18 00:33 [medline] PHST- 2026/06/18 00:32 [pubmed] PHST- 2026/06/17 21:12 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - bmjopen-2025-111298 [pii] AID - 10.1136/bmjopen-2025-111298 [doi] PST - epublish SO - BMJ Open. 2026 Jun 17;16(6):e111298. doi: 10.1136/bmjopen-2025-111298. PMID- 42308182 OWN - NLM STAT- MEDLINE DCOM- 20260617 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 6 DP - 2026 TI - A risk assessment indicator system for common diseases in children and adolescents. PG - e0351870 LID - 10.1371/journal.pone.0351870 [doi] LID - e0351870 AB - BACKGROUND: Adolescence is a critical stage for healthy development. Currently, common diseases such as myopia, obesity, dental caries, and spinal curvature abnormalities are highly prevalent among children and adolescents, with an obvious trend of younger onset. These diseases are caused by the complex interaction of multi-dimensional factors. However, existing interventions are mostly limited to individual diseases, lacking systematic prevention and control tools. Therefore, there is an urgent need to construct a scientific evaluation index system for health-influencing factors. OBJECTIVE: Targeting the four key common diseases emphasized in China's national health policies - myopia, obesity, dental caries, and spinal curvature abnormalities - among children and adolescents aged 7-19 years, this study constructed a multi-dimensional risk assessment indicator system to support evidence-based prevention and policy-making for this population. METHODS: Guided by the National Program of Action for Children's Development in China (2021-2030) and the "Healthy China 2030" Planning Outline, a three-level indicator framework was initially formulated through literature research and expert meetings. The Delphi expert consultation method was adopted for two rounds of screening and optimization of indicators. Experts scored each indicator on a scale of 1-5 in terms of importance, feasibility, and sensitivity, with indicators excluded if their mean score was < 3.5 and coefficient of variation >0.3. RESULTS: The effective return rate of the two-round Delphi is 100.0%, the mean expert familiarity coefficient (Cs) was 0.83, and the mean judgment coefficient (Ca) was 0.93, and the expert authoritative coefficient (Cr) value is 0.88. In the second round of consultation, the importance coordination coefficient is 0.284, the feasibility coordination coefficient is 0.185, and the sensitivity coordination coefficient is 0.314, all of which are statistically significant (P < 0.001). This indicator system consists of a total of 55 three-level indicators. CONCLUSION: Validated through two rounds of expert deliberation, the indicator system demonstrates sound scientific rigor. The preliminary development of a risk assessment indicator system for common diseases in children and adolescents can be used for the measurement of the level of factors affecting the health of common diseases in children and adolescents after its reliability and validity are verified in practical applications. CI - Copyright: (c) 2026 Shao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Shao, Yun AU - Shao Y AD - School of Public Health, Fudan University, Shanghai, China. AD - Shanghai Putuo District Center for Disease Control and Prevention, Shanghai, China. FAU - Hu, Bohan AU - Hu B AD - School of Public Health, Fudan University, Shanghai, China. AD - Shanghai Putuo District Center for Disease Control and Prevention, Shanghai, China. FAU - Lu, Yuting AU - Lu Y AD - School of Public Health, Fudan University, Shanghai, China. AD - Shanghai Putuo District Center for Disease Control and Prevention, Shanghai, China. FAU - Yu, Shuo AU - Yu S AD - NHC Key Laboratory of Health Technology Assessment (Fudan University), Shanghai, China. FAU - Liang, Ji AU - Liang J AUID- ORCID: 0000-0002-6844-5036 AD - School of Public Health, Fudan University, Shanghai, China. AD - Shanghai Putuo District Center for Disease Control and Prevention, Shanghai, China. LA - eng PT - Journal Article DEP - 20260617 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Child MH - Adolescent MH - Risk Assessment/methods MH - China/epidemiology MH - Female MH - Male MH - *Dental Caries/epidemiology/prevention & control MH - *Myopia/epidemiology/prevention & control MH - *Obesity/epidemiology/prevention & control MH - Young Adult PMC - PMC13274816 COIS- The authors have declared that no competing interests exist. EDAT- 2026/06/17 18:35 MHDA- 2026/06/17 18:36 PMCR- 2026/06/17 CRDT- 2026/06/17 13:33 PHST- 2025/11/08 00:00 [received] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/06/17 18:36 [medline] PHST- 2026/06/17 18:35 [pubmed] PHST- 2026/06/17 13:33 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - PONE-D-25-58634 [pii] AID - 10.1371/journal.pone.0351870 [doi] PST - epublish SO - PLoS One. 2026 Jun 17;21(6):e0351870. doi: 10.1371/journal.pone.0351870. eCollection 2026. PMID- 42307104 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260709 IS - 1522-1601 (Electronic) IS - 0161-7567 (Linking) VI - 141 IP - 1 DP - 2026 Jul 1 TI - Genetic risk scores are related to bone microarchitecture in US Army basic training. PG - 226-235 LID - 10.1152/japplphysiol.00181.2026 [doi] AB - Trainees in US Army basic combat training (BCT) frequently experience vitamin D deficiency and bone stress injuries. It remains unclear how genetic variation influences these outcomes, either through direct effects on skeletal adaptations to training or by increasing susceptibility to vitamin D insufficiency, which in turn affects skeletal adaptations and injury risk. This study investigated whether single-nucleotide polymorphisms (SNPs) or genetic risk scores (GRS) previously related to vitamin D and bone health were associated with tibial bone microarchitecture during BCT. A cohort of 2,550 healthy young adults (36% female) underwent high-resolution peripheral quantitative computed tomography scans at the distal tibia before BCT and, in a subset (n = 1,514), again after BCT. The following GRS or SNPs were evaluated: vitamin D receptor, vitamin D binding protein, 25-hydroxy-vitamin D (25-OHD)-GRS, adult-GRS, fracture-GRS, pediatric-GRS, Wingless/Int-1 (WNT)-GRS, RANK-RANKL-OPG-GRS (RANK-GRS), and mesenchymal stem cell differentiation GRS (Mes-GRS). Multivariable linear regression models were adjusted for age, sex, body mass index, and 25-OHD concentration. Following correction for multiple testing, 47 significant associations emerged. The adult-GRS was negatively associated with volumetric bone mineral density (vBMD), trabecular vBMD, and bone volume fraction in White non-Hispanic, Hispanic trainees, and Other Races Combined. The fracture-GRS was associated with trabecular and cortical microarchitecture across three groups/ethnicities, whereas the pediatric-GRS primarily showed associations in White non-Hispanic individuals. RANK-GRS correlated with trabecular microstructure in White non-Hispanic and Other Races Combined, and WNT-GRS was associated with cortical volumetric BMD in White non-Hispanics. No associations were observed between vitamin D SNPs or GRS and changes in bone during BCT. These findings suggest that GRS previously related to bone density and remodeling pathways are associated with bone microarchitecture in young adults, whereas vitamin D-related GRS were not associated with tibial microarchitecture during BCT.NEW & NOTEWORTHY In 2,550 US Army trainees undergoing basic combat training, genetic risk scores were associated with tibial volumetric BMD and microarchitecture measured by HR-pQCT. These effects persisted in skeletally mature young adults under intense mechanical loading and across ancestry groups. In contrast, vitamin D-related genetic variants were not associated with skeletal traits or adaptation. Large-scale validation in this well-characterized cohort strengthens evidence linking established bone loci to microarchitectural phenotypes. FAU - Roberts, Brandon M AU - Roberts BM AUID- ORCID: 0000-0003-0395-6967 AD - US Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States. FAU - Hendricks, Jessie AU - Hendricks J AD - MIT Lincoln Laboratory, Lexington, Massachusetts, United States. FAU - Guerriere Aaron, Katelyn AU - Guerriere Aaron K AD - US Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States. FAU - Walker, Leila A AU - Walker LA AD - US Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States. FAU - Sczuroski, Cara E AU - Sczuroski CE AUID- ORCID: 0009-0008-2890-5713 AD - US Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States. FAU - Geddis, Alyssa V AU - Geddis AV AD - US Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States. FAU - Staab, Janet E AU - Staab JE AD - US Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States. FAU - Staab, Jeffery S AU - Staab JS AUID- ORCID: 0000-0003-0080-1441 AD - US Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States. FAU - Taylor, Kathryn M AU - Taylor KM AUID- ORCID: 0000-0002-6509-4752 AD - US Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States. FAU - McClung, James P AU - McClung JP AD - US Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States. FAU - Foulis, Stephen A AU - Foulis SA AUID- ORCID: 0000-0002-8437-5058 AD - US Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States. FAU - Hughes, Julie M AU - Hughes JM AD - US Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States. FAU - Petrovick, Martha AU - Petrovick M AD - MIT Lincoln Laboratory, Lexington, Massachusetts, United States. FAU - Gaffney-Stomberg, Erin AU - Gaffney-Stomberg E AD - US Army Combat Capabilities Development Command Soldier Center, Natick, Massachusetts, United States. LA - eng GR - Military Operational Medicine Research Program (MOMRP)/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260617 PL - United States TA - J Appl Physiol (1985) JT - Journal of applied physiology (Bethesda, Md. : 1985) JID - 8502536 RN - 1406-16-2 (Vitamin D) SB - IM DRIN- J Colloid Interface Sci. 2020 Jun 1;569:254-266. doi: 10.1016/j.jcis.2020.02.053. PMID: 32114104 MH - Humans MH - Female MH - *Military Personnel MH - Genetic Risk Score MH - Polymorphism, Single Nucleotide/genetics MH - Male MH - Young Adult MH - Bone Density/genetics MH - *Bone and Bones/physiology MH - Adult MH - Vitamin D/analogs & derivatives MH - *Tibia/physiology MH - Vitamin D Deficiency/genetics MH - United States MH - Genetic Predisposition to Disease OTO - NOTNLM OT - exercise OT - military OT - nutrition OT - training OT - vitamin D EDAT- 2026/06/17 13:28 MHDA- 2026/07/09 12:33 CRDT- 2026/06/17 08:04 PHST- 2026/07/09 12:33 [medline] PHST- 2026/06/17 13:28 [pubmed] PHST- 2026/06/17 08:04 [entrez] AID - 10.1152/japplphysiol.00181.2026 [doi] PST - ppublish SO - J Appl Physiol (1985). 2026 Jul 1;141(1):226-235. doi: 10.1152/japplphysiol.00181.2026. Epub 2026 Jun 17. PMID- 42304432 OWN - NLM STAT- MEDLINE DCOM- 20260618 LR - 20260813 IS - 1868-7083 (Electronic) IS - 1868-7075 (Print) IS - 1868-7075 (Linking) VI - 18 IP - 1 DP - 2026 Jun 16 TI - Blood DNA methylation of EIF5A and TGIF1 is associated with adipose tissue health and metabolic outcomes in obesity: a multi-cohort study. LID - 10.1186/s13148-026-02177-y [doi] LID - 118 AB - BACKGROUND: Blood-based DNA methylation has been linked to obesity and metabolic health, yet its relationship to adipose tissue function remains incompletely understood. This study aimed to investigate the epigenetic regulation of EIF5A (Eukaryotic translation initiation factor 5A-1) and TGIF1 (TGFB Induced Factor Homeobox 1) across blood and adipose tissue in obesity. METHODS: Candidate genes were identified using a multi-step gene selection approach integrating transcriptomic and epigenomic data from blood and adipose tissue samples obtained from children and adults across four diverse population- and disease-focused cohorts. Genes were prioritized based on differential DNA methylation and gene expression in obesity. Targeted bisulfite sequencing of EIF5A and TGIF1 was conducted in blood samples from adults across BMI-defined groups and from children prior to the development of obesity, to validate candidate loci and to examine associations with metabolic and adipocyte-related phenotypes. RESULTS: In adults from the Leipzig Obesity BioBank, blood DNA methylation (N = 150) of both EIF5A and TGIF1 was significantly increased in individuals with obesity. EIF5A mRNA expression (N = 1554) was significantly higher in omental-visceral adipose tissue compared with subcutaneous adipose tissue. Blood DNA methylation of EIF5A was associated with body mass index (BMI), glycated hemoglobin (HbA1c), and leukocyte counts, particularly among individuals with type 2 diabetes mellitus. In children, blood DNA methylation (N = 75) of EIF5A was associated with longitudinal HbA1c trajectories. For TGIF1, DNA methylation levels were increased in subcutaneous adipose tissue (N = 219) of children with obesity and correlated with fasting serum insulin concentrations. Across cohorts, TGIF1 regulation in both blood and adipose tissue showed consistent associations with adipocyte size. Notably, blood DNA methylation of TGIF1 in childhood was associated with body fat mass and HbA1c at later follow-up despite normal weight at baseline. CONCLUSION: EIF5A and TGIF1 DNA methylation represent cross-tissue epigenetic signatures linking blood-based DNA methylation to adipose tissue dysfunction, adipocyte hypertrophy, and early metabolic risk. These findings support the potential of blood DNA methylation markers to reflect adipose tissue health and metabolic outcomes across the lifespan. CI - (c) 2026. The Author(s). FAU - Ruf, Sophie AU - Ruf S AD - Medical Department III - Endocrinology, Nephrology and Rheumatology, Leipzig University, Liebigstrasse 19, 04103, Leipzig, Germany. FAU - Hoffmann, Anne AU - Hoffmann A AD - Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Munich at Leipzig University and University of Leipzig Medical Center, Philipp-Rosenthal Str. 27, 04103, Leipzig, Germany. FAU - Muller, Luise AU - Muller L AD - Medical Department III - Endocrinology, Nephrology and Rheumatology, Leipzig University, Liebigstrasse 19, 04103, Leipzig, Germany. FAU - Landgraf, Kathrin AU - Landgraf K AD - Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Munich at Leipzig University and University of Leipzig Medical Center, Philipp-Rosenthal Str. 27, 04103, Leipzig, Germany. AD - Center for Pediatric Research, Leipzig University, Medical Faculty, University Hospital for Children and Adolescents, Leipzig, Germany. AD - German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden, Leipzig, Germany. FAU - Vogel, Mandy AU - Vogel M AD - Center for Pediatric Research, Leipzig University, Medical Faculty, University Hospital for Children and Adolescents, Leipzig, Germany. AD - German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden, Leipzig, Germany. AD - LIFE - Leipzig Research Centre for Civilization Diseases, Leipzig University, Leipzig, Germany. FAU - Jorsboe, Emil AU - Jorsboe E AD - Nuffield Department of Population Health, University of Oxford, Oxford, UK. AD - Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK. AD - Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. AD - Center for Liver Research, Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark. FAU - Kubitz, Phil AU - Kubitz P AD - Else Kroner-Fresenius-Center for Nutritional Medicine, Chair of Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising-Weihenstephan, Germany. AD - Institute for Nutritional Medicine, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Dietrich, Arne AU - Dietrich A AD - Medical Department of Visceral, Transplantation, Thoracic and Vascular Surgery, University of Leipzig, Leipzig, Germany. FAU - Ghosh, Adhideb AU - Ghosh A AD - Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland. FAU - Noe, Falko AU - Noe F AD - Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland. FAU - Wolfrum, Christian AU - Wolfrum C AD - Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland. FAU - Claussnitzer, Melina AU - Claussnitzer M AD - Medical and Population Genetics Program & Broad Diabetes Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. AD - Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA. AD - Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. FAU - Hauner, Hans AU - Hauner H AD - Else Kroner-Fresenius-Center for Nutritional Medicine, Chair of Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising-Weihenstephan, Germany. AD - Institute for Nutritional Medicine, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Stumvoll, Michael AU - Stumvoll M AD - Medical Department III - Endocrinology, Nephrology and Rheumatology, Leipzig University, Liebigstrasse 19, 04103, Leipzig, Germany. AD - Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Munich at Leipzig University and University of Leipzig Medical Center, Philipp-Rosenthal Str. 27, 04103, Leipzig, Germany. AD - LeiCeM - Leipzig Center of Metabolism, Leipzig University, Leipzig, Germany. FAU - Baber, Ronny AU - Baber R AD - German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden, Leipzig, Germany. AD - LIFE - Leipzig Research Centre for Civilization Diseases, Leipzig University, Leipzig, Germany. AD - Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, Leipzig University, Leipzig, Germany. FAU - Bluher, Matthias AU - Bluher M AD - Medical Department III - Endocrinology, Nephrology and Rheumatology, Leipzig University, Liebigstrasse 19, 04103, Leipzig, Germany. AD - Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Munich at Leipzig University and University of Leipzig Medical Center, Philipp-Rosenthal Str. 27, 04103, Leipzig, Germany. AD - LeiCeM - Leipzig Center of Metabolism, Leipzig University, Leipzig, Germany. AD - German Center for Diabetes Research (DZD), Neuherberg, Germany. FAU - Korner, Antje AU - Korner A AD - Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Munich at Leipzig University and University of Leipzig Medical Center, Philipp-Rosenthal Str. 27, 04103, Leipzig, Germany. AD - Center for Pediatric Research, Leipzig University, Medical Faculty, University Hospital for Children and Adolescents, Leipzig, Germany. AD - German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden, Leipzig, Germany. AD - LIFE - Leipzig Research Centre for Civilization Diseases, Leipzig University, Leipzig, Germany. AD - LeiCeM - Leipzig Center of Metabolism, Leipzig University, Leipzig, Germany. FAU - Kovacs, Peter AU - Kovacs P AD - Medical Department III - Endocrinology, Nephrology and Rheumatology, Leipzig University, Liebigstrasse 19, 04103, Leipzig, Germany. peter.kovacs@medizin.uni-leipzig.de. AD - German Center for Diabetes Research (DZD), Neuherberg, Germany. peter.kovacs@medizin.uni-leipzig.de. FAU - Keller, Maria AU - Keller M AD - Medical Department III - Endocrinology, Nephrology and Rheumatology, Leipzig University, Liebigstrasse 19, 04103, Leipzig, Germany. maria.keller@helmholtz-munich.de. AD - Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Munich at Leipzig University and University of Leipzig Medical Center, Philipp-Rosenthal Str. 27, 04103, Leipzig, Germany. maria.keller@helmholtz-munich.de. AD - German Center for Diabetes Research (DZD), Neuherberg, Germany. maria.keller@helmholtz-munich.de. LA - eng PT - Journal Article DEP - 20260616 PL - Germany TA - Clin Epigenetics JT - Clinical epigenetics JID - 101516977 RN - 0 (Homeodomain Proteins) RN - 0 (RNA-Binding Proteins) RN - 0 (Eukaryotic Translation Initiation Factor 5A) RN - 0 (Peptide Initiation Factors) RN - 0 (Repressor Proteins) RN - 0 (TGIF1 protein, human) RN - 0 (Glycated Hemoglobin) SB - IM MH - Humans MH - *DNA Methylation MH - Female MH - Male MH - *Homeodomain Proteins/genetics/blood MH - *Obesity/genetics/blood/metabolism MH - *RNA-Binding Proteins/genetics/blood MH - Eukaryotic Translation Initiation Factor 5A MH - *Peptide Initiation Factors/genetics/blood MH - *Repressor Proteins/genetics/blood MH - *Adipose Tissue/metabolism MH - Child MH - Cohort Studies MH - Adult MH - Epigenesis, Genetic MH - Body Mass Index MH - Middle Aged MH - Glycated Hemoglobin PMC - PMC13274240 OTO - NOTNLM OT - Adipose tissue OT - Blood OT - Childhood OT - DNA methylation OT - Epigenetics OT - Metabolism OT - Obesity OT - mRNA expression COIS- Declarations. Ethics approval and consent to participate: All participants or their parents gave written informed consent to participate in the studies. Procedures were approved by the University of Leipzig's ethics committee (LIFE Adult: Reg. No. 263-2009-14122009; LOBB: Reg. No. 159-12-21052012, 017ek-2012; LIFE Child: Reg. No. 264-10-19042010; Leipzig AT Childhood cohort: Reg. No. 265-08, 265-08-ff, NCT02208141) and conducted according to the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: MB received honoraria as a consultant and speaker from Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Lilly, Novo Nordisk, Novartis, and Sanofi. All other authors declare no conflicts of interest. The funders had no role in the design of the study, the collection, analyses, or interpretation of data, in the decision to publish the results and the writing of the manuscript. EDAT- 2026/06/17 06:31 MHDA- 2026/06/18 06:32 PMCR- 2026/06/16 CRDT- 2026/06/17 00:13 PHST- 2026/02/27 00:00 [received] PHST- 2026/05/30 00:00 [accepted] PHST- 2026/06/18 06:32 [medline] PHST- 2026/06/17 06:31 [pubmed] PHST- 2026/06/17 00:13 [entrez] PHST- 2026/06/16 00:00 [pmc-release] AID - 10.1186/s13148-026-02177-y [pii] AID - 2177 [pii] AID - 10.1186/s13148-026-02177-y [doi] PST - epublish SO - Clin Epigenetics. 2026 Jun 16;18(1):118. doi: 10.1186/s13148-026-02177-y. PMID- 42304271 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 16 TI - Base deficit and alactic base excess are promising early biological markers in pediatric sepsis. LID - 10.1186/s12887-026-07152-3 [doi] LID - 712 AB - BACKGROUND AND AIMS: The diagnosis and management of pediatric sepsis remain challenging and time-sensitive. Early biological markers that may identify patients at risk of progression to septic shock are needed. Base deficit (BD) has been associated with adverse outcomes in adult sepsis, while alactic base excess (ABE) reflects non-lactate metabolic acidosis. This study aimed to evaluate the performance of BD and ABE compared with lactate in pediatric sepsis and to assess their association with time to progression to septic shock. METHODS: This retrospective single-center cohort study included pediatric patients with sepsis between January 1, 2020, and September 1, 2024. Biomarkers were obtained at initial presentation prior to resuscitation. BD and ABE were categorized into normal, abnormal, and extremely abnormal groups based on distribution thresholds, while lactate was classified as normal (2.2 mmol/L). Diagnostic performance was assessed using ROC curve analysis. Time-to-event analyses were performed using Kaplan-Meier curves and multivariable Cox regression models adjusted for BMI, CRP, albumin, and Phoenix Sepsis Score. RESULTS: A total of 44 patients were included, of whom 30 (68.18%) developed septic shock. Lactate demonstrated lower discriminative performance (AUC 0.624, 95% CI 0.447-0.800) compared with BD (AUC 0.940, 95% CI 0.875-0.999) and ABE (AUC 0.905, 95% CI 0.813-0.997). Both BD and ABE showed higher sensitivity and specificity for identifying patients who progressed to septic shock. In adjusted analyses, abnormal and extremely abnormal ABE and BD were associated with an increased hazard of progression to septic shock. Median time to shock was shortest in patients with extremely abnormal BD and ABE (approximately 8-9 hours), followed by abnormal lactate (13 hours), abnormal ABE (17 hours), and abnormal BD (18 hours). CONCLUSIONS: BD and ABE were associated with progression to septic shock in pediatric sepsis and may provide clinically relevant information for early risk stratification. In this cohort, these markers demonstrated stronger discriminative performance than lactate and may reflect metabolic disturbances present earlier in the disease course. However, these findings should be interpreted cautiously given the retrospective design and require prospective multicenter validation before clinical implementation. CI - (c) 2026. The Author(s). FAU - Assaad, Amani AU - Assaad A AD - Division of Pediatric Critical Care Medicine, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon. FAU - Majdalani, Marianne AU - Majdalani M AD - Division of Pediatric Critical Care Medicine, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon. FAU - Ismail, Ali AU - Ismail A AD - Division of Pediatric Critical Care Medicine, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon. FAU - Moukhaiber, Jihane AU - Moukhaiber J AUID- ORCID: 0009-0008-4370-9809 AD - Division of Pediatric Critical Care Medicine, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon. jm88@aub.edu.lb. LA - eng PT - Journal Article DEP - 20260616 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 RN - 0 (Biomarkers) RN - 33X04XA5AT (Lactic Acid) SB - IM MH - Humans MH - Biomarkers/blood MH - Retrospective Studies MH - Female MH - *Sepsis/blood/diagnosis/complications MH - Male MH - Child MH - *Lactic Acid/blood MH - Shock, Septic/diagnosis/blood/etiology MH - Child, Preschool MH - Disease Progression MH - Infant MH - ROC Curve MH - *Acid-Base Imbalance/diagnosis/blood PMC - PMC13445687 OTO - NOTNLM OT - Alactic base excess. OT - Base deficit OT - Lactate OT - Pediatrics OT - Sepsis OT - Septic shock COIS- Declarations. Ethical approval and consent to participate: The Institutional Review Board at AUBMC approved this study (BIO-2024-0043) on October 24, 2024, in accordance with the ethical principles of Belmont, 1979. Waiver for consent was approved by the Institutional Review Board as this is a retrospective observational study, and the research team are not involved in the clinical care of the collected patients. The waiver did not adversely affect the rights or welfare of the subjects, as their information was coded and handled with confidentiality, ensuring privacy and compliance with the ethical standards. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/17 06:32 MHDA- 2026/08/06 11:36 PMCR- 2026/06/16 CRDT- 2026/06/17 00:05 PHST- 2025/08/22 00:00 [received] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/08/06 11:36 [medline] PHST- 2026/06/17 06:32 [pubmed] PHST- 2026/06/17 00:05 [entrez] PHST- 2026/06/16 00:00 [pmc-release] AID - 10.1186/s12887-026-07152-3 [pii] AID - 7152 [pii] AID - 10.1186/s12887-026-07152-3 [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 16;26(1):712. doi: 10.1186/s12887-026-07152-3. PMID- 42304257 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260917 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 16 TI - Cross-cultural adaptation of the Spanish version of the Swimming with Independent Measure (SWIM). LID - 10.1186/s12887-026-07054-4 [doi] LID - 796 AB - BACKGROUND: Assessing aquatic functional abilities is essential for designing effective interventions for children and adolescents who undergo aquatic activities and/or therapy. However, there is a lack of validated instruments in Spanish addressing this need. The Swimming with Independent Measure (SWIM) assesses functional performance in aquatic environments across typical and atypical development. This study aimed to cross-culturally adapt and to evaluate content equivalence and face validity of the SWIM for use with Spanish-speaking professionals working in aquatic environments with children and adolescents. METHOD: A methodological study was conducted to perform the cross-cultural adaptation of the SWIM and evaluate its content equivalence and face validity. Cross-cultural adaptation followed Beaton's six-phase methodology: translation, synthesis, back-translation, expert committee review, and pilot testing. Two translators and two back-translators performed the linguistic adaptation. A multidisciplinary expert committee (n = 5) evaluated content equivalence, and 20 professionals meeting predefined eligibility criteria participated in pilot testing. Content equivalence was assessed during the expert committee review, while face validity was evaluated during pilot testing. RESULTS: After two expert committee rounds, 83.6% of items were classified as conceptually equivalent and 16.4% as similar. Content equivalence indices improved from Ave-CVI = 0.93 to 1.00 and UA-CVI = 0.73 to 1.00. Pilot testing with 20 professionals confirmed adequate comprehensibility, requiring minor revisions to a few items. The final Spanish version showed adequate content equivalence and satisfactory face validity. CONCLUSIONS: The Spanish version of the SWIM was cross-culturally adapted, demonstrating semantic, conceptual, idiomatic, and content equivalence with the original, and showed adequate face validity. CI - (c) 2026. The Author(s). FAU - Gavina-Barroso, Maria Isabel AU - Gavina-Barroso MI AUID- ORCID: 0000-0002-5685-7252 AD - Universidad Europea de Madrid. Faculty of Medicine, Health and Sports. Department of Physiotherapy. Campus de Villaviciosa, Calle Tajo s/n, Villaviciosa de Odon, Madrid, 28670, Spain. FAU - Pacheco-da-Costa, Soraya AU - Pacheco-da-Costa S AUID- ORCID: 0000-0002-2226-3560 AD - Universidad de Alcala. Faculty of Medicine and Health Sciences. Department of Nursing and Physiotherapy. Neuromusculoskeletal Physical Therapy in Stages of Life Research Group (FINEMEV). Instituto de Investigacion Sanitaria de Castilla-La Mancha (IDISCAM), Campus Universitario Externo, Autovia A2, km 33,200, Alcala de Henares, 28805, Spain. soraya.pacheco@uah.es. FAU - Rodriguez-Costa, Isabel AU - Rodriguez-Costa I AUID- ORCID: 0000-0002-6645-2187 AD - Universidad de Alcala. Faculty of Medicine and Health Sciences, Department of Nursing and Physical Therapy, Humanization in the Intervention of Physiotherapy for the Integral Attention to the People (HIPATIA) Research Group, Campus Universitario Externo, Autovia A2, km 33,200, Alcala de Henares, 28805, Spain. FAU - Garcia-Perez-de-Sevilla, Guillermo AU - Garcia-Perez-de-Sevilla G AUID- ORCID: 0000-0002-2689-1767 AD - Universidad Europea de Madrid. Faculty of Medicine, Health and Sports. Department of Physiotherapy, Campus de Villaviciosa, Calle Tajo s/n, Villaviciosa de Odon, Madrid, 28670, Spain. FAU - Martinez-Caro, Leticia AU - Martinez-Caro L AUID- ORCID: 0000-0003-3486-4678 AD - Faculty of Health Sciences, UNIR., Avda. de La Paz, 137, Logrono, La Rioja, 26006, Spain. FAU - Sanchez-Sanchez, Beatriz AU - Sanchez-Sanchez B AUID- ORCID: 0000-0002-0223-9707 AD - Universidad de Alcala. Faculty of Medicine and Health Sciences. Department of Nursing and Physiotherapy, Physiotherapy in Women's Health (FPSM) Research Group, Campus Universitario Externo, Autovia A2, km 33,200, Alcala de Henares, 28805, Spain. AD - Ramon y Cajal Institute of Health Research - IRYCIS, Hospital Universitario Ramon y Cajal, Madrid, 28034, Spain. LA - eng PT - Journal Article PT - Validation Study DEP - 20260616 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Swimming/physiology MH - *Cross-Cultural Comparison MH - Child MH - Reproducibility of Results MH - Adolescent MH - Translations MH - Spain MH - Male MH - Female MH - Pilot Projects PMC - PMC13520382 OTO - NOTNLM OT - Aquatic functional abilities OT - Aquatic therapy OT - Content equivalence OT - Cross-cultural adaptation OT - Face validity OT - Halliwick concept OT - Motor function in water COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Hospital Clinico San Carlos Ethics Committee, under the reference number CI 19/495-E. All procedures were conducted in accordance with established ethical standards and relevant guidelines. Competing interests: The authors declare no competing interests. EDAT- 2026/06/17 06:32 MHDA- 2026/08/27 05:35 PMCR- 2026/06/16 CRDT- 2026/06/17 00:05 PHST- 2025/07/30 00:00 [received] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/08/27 05:35 [medline] PHST- 2026/06/17 06:32 [pubmed] PHST- 2026/06/17 00:05 [entrez] PHST- 2026/06/16 00:00 [pmc-release] AID - 10.1186/s12887-026-07054-4 [pii] AID - 7054 [pii] AID - 10.1186/s12887-026-07054-4 [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 16;26(1):796. doi: 10.1186/s12887-026-07054-4. PMID- 42302708 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1525-1438 (Electronic) IS - 1048-891X (Linking) VI - 36 IP - 7 DP - 2026 Jul TI - Menopausal hormone therapy prescription and ovary-sparing surgery in women with pre-menopausal endometrial cancer: a Swedish PremEnCa study. PG - 104776 LID - S1048-891X(26)00307-5 [pii] LID - 10.1016/j.ijgc.2026.104776 [doi] AB - OBJECTIVE: The use of ovary-sparing surgery and menopausal hormone therapy after endometrial cancer is controversial, requiring a balance between a presumed increased risk of recurrence and the well-known adverse effects of premature menopause. Studies on this topic, specifically in pre-menopausal women, are scarce and heterogeneous. This nationwide, population-based, retrospectively conducted cohort study aimed to describe the use of ovary-sparing surgery and post-treatment menopausal hormone therapy in pre-menopausal women with endometrial cancer and to analyze related factors. METHODS: The study population comprised women aged /= 37 weeks), with a detection rate of 95.12% at the recommended risk cutoff of 1 in 100. CONCLUSION: First-trimester screening using PlGF, PAPP-A, and maternal factors shows preliminary associations with common obstetric complications, suggesting the potential utility of these biomarkers in early risk stratification, providing a proof-of-concept tool for early risk stratification and improved management of high-risk pregnancies to reduce maternal and fetal morbidity. However, these models require validation in larger, more diverse populations before clinical consideration. CI - (c) 2026. The Author(s). FAU - Hua, Renyi AU - Hua R AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Li, Shuyuan AU - Li S AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Han, Xu AU - Han X AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Tang, Ziyuan AU - Tang Z AD - Revvity, Ltd., Women and Children Diagnosis, Shanghai, China. FAU - Ye, Baoying AU - Ye B AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Tan, Yuru AU - Tan Y AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Wang, Shan AU - Wang S AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Sun, Jinling AU - Sun J AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Cheng, Weiwei AU - Cheng W AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. wwcheng29@163.com. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. wwcheng29@163.com. FAU - Wang, Yanlin AU - Wang Y AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. wyanlin@163.com. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. wyanlin@163.com. LA - eng PT - Journal Article DEP - 20260615 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM OTO - NOTNLM OT - Fetal growth restriction OT - First trimester OT - Placenta previa OT - Placental biomarkers OT - Pre-eclampsia OT - Pregnancy OT - Preterm birth COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Review Board of the International Peace Maternity and Child Health Hospital Affiliated with the Shanghai JiaoTong University School of Medicine (Approval No. GKLW2019-20).Written informed consent was obtained from all participants prior to enrollment. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/16 06:35 MHDA- 2026/06/16 06:35 CRDT- 2026/06/16 00:37 PHST- 2025/02/13 00:00 [received] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/06/16 06:35 [medline] PHST- 2026/06/16 06:35 [pubmed] PHST- 2026/06/16 00:37 [entrez] AID - 10.1186/s12884-026-09417-2 [pii] AID - 10.1186/s12884-026-09417-2 [doi] PST - aheadofprint SO - BMC Pregnancy Childbirth. 2026 Jun 15. doi: 10.1186/s12884-026-09417-2. PMID- 42298014 OWN - NLM STAT- Publisher LR - 20260615 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Jun 15 TI - Nutritional screening predicts prolonged stay in LMIC pediatric oncology settings: SCAN validation in Brazilian children. LID - 10.1038/s41390-026-05200-3 [doi] AB - BACKGROUND: Malnutrition affects 50-90% of children with cancer in low- and middle-income countries (LMICs) and worsens clinical outcomes. The Nutrition Screening Tool for Childhood Cancer (SCAN) is cancer-specific but has not been validated in Brazilian Portuguese. We aimed to evaluate the diagnostic accuracy of the Brazilian Portuguese SCAN (SCAN pt-BR) against STRONGkids and to examine its association with prolonged hospitalization and ICU admission. METHODS: Prospective diagnostic-accuracy study at a tertiary pediatric oncology center in Brazil (February-December 2021). Consecutive inpatients aged 1-18 years with expected stay >/=48 h were screened within 24-48 h of admission by pediatric dietitians using SCAN pt-BR and STRONGkids. RESULTS: Of 262 children (median age 8.8 years, 52.7% male, 41.2% hematologic malignancies), 70.2% were classified as at risk by SCAN pt-BR. Against STRONGkids >/=4, SCAN showed sensitivity 94.6%, specificity 43.2%, and ROC-AUC 0.863. SCAN risk independently predicted prolonged stay (adjusted OR 2.33, 95% CI 1.29-4.30, p = 0.006) but not ICU admission (adjusted OR 0.96, p = 0.899). CONCLUSION: SCAN pt-BR showed adequate screening performance and independently predicted prolonged hospitalization in Brazilian children with cancer. These results support its use for admission nutritional triage in LMIC pediatric oncology settings. IMPACT: SCAN identified 70.2% of children as at nutritional risk and predicted prolonged hospitalization (adjusted OR 2.33, 95% CI 1.29-4.30) independently of age, tumor group, and STRONGkids classification. Against STRONGkids high-risk classification, SCAN pt-BR showed high sensitivity (94.6%), high negative predictive value (93.6%), and ROC-AUC of 0.863. Gastrointestinal symptoms, poor oral intake, and recent weight loss were the most frequently endorsed symptom-related items that children classified as at nutritional risk, suggesting that SCAN detects acute nutritional deterioration rather than static disease characteristics. Routine application at admission could direct early dietetic referral to children most likely to require prolonged inpatient care. CI - (c) 2026. The Author(s). FAU - Duarte, Mariana Murra AU - Duarte MM AD - Department of Clinical Nutrition, Children's Cancer Hospital, Barretos Cancer Hospital, Barretos, SP, Brazil. FAU - da Silva, Marielle Ferreira AU - da Silva MF AD - Department of Clinical Nutrition, Children's Cancer Hospital, Barretos Cancer Hospital, Barretos, SP, Brazil. FAU - Alexandre, Maynara Cristina AU - Alexandre MC AD - Department of Clinical Nutrition, Children's Cancer Hospital, Barretos Cancer Hospital, Barretos, SP, Brazil. FAU - Fermino, Marise Lopes AU - Fermino ML AD - Barretos Medical School, Faculdade de Ciencias da Saude "Dr Paulo Prata" (FACISB), Barretos, SP, Brazil. FAU - do Nascimento, Ana Laura Balduino AU - do Nascimento ALB AD - Barretos Medical School, Faculdade de Ciencias da Saude "Dr Paulo Prata" (FACISB), Barretos, SP, Brazil. AD - "Innovation in Healthcare" Post-graduation Program, Barretos Cancer Hospital, Barretos, SP, Brazil. FAU - de Oliveira, Wilson Elias Jr AU - de Oliveira WE Jr AUID- ORCID: 0000-0001-9812-6282 AD - "Innovation in Healthcare" Post-graduation Program, Barretos Cancer Hospital, Barretos, SP, Brazil. woliveirajr.cipe@gmail.com. AD - Department of Pediatric Surgery, Children's Cancer Hospital, Barretos Cancer Hospital, Barretos, SP, Brazil. woliveirajr.cipe@gmail.com. LA - eng PT - Journal Article DEP - 20260615 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Consent statement: This study was conducted in accordance with the Declaration of Helsinki and Brazilian national research ethics guidelines. The protocol was approved by the Research Ethics Committee of the Hospital de Cancer de Barretos (REB #3.827.548/2019). Written informed consent was obtained from all parents or legal guardians before enrollment. EDAT- 2026/06/16 00:33 MHDA- 2026/06/16 00:33 CRDT- 2026/06/15 23:37 PHST- 2026/02/11 00:00 [received] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/05/12 00:00 [revised] PHST- 2026/06/16 00:33 [medline] PHST- 2026/06/16 00:33 [pubmed] PHST- 2026/06/15 23:37 [entrez] AID - 10.1038/s41390-026-05200-3 [pii] AID - 10.1038/s41390-026-05200-3 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Jun 15. doi: 10.1038/s41390-026-05200-3. PMID- 42298003 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20261023 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jun 15 TI - Dietary patterns are associated with premenstrual symptoms: a cross-sectional study among women from Central Europe. LID - 10.1038/s41598-026-58236-0 [doi] LID - 27317 AB - To date, only a few studies have examined the relationship between dietary patterns and premenstrual syndrome (PMS), and these have been limited to Asian populations with inconclusive results, while studies in European populations are lacking. Therefore, this study aimed to examine the associations between dietary patterns and the severity of PMS in young women from a European population. This cross-sectional study included 609 women aged 18-35 years. Premenstrual symptoms and their severity were assessed using the validated Premenstrual Symptoms Screening Tool, dietary intake data were collected using a semiquantitative food frequency questionnaire, and dietary patterns were determined via K-means clustering of 13 food groups. Three dietary patterns (DPs) were identified: Healthy-DP, Western-DP, and Low-food-DP (characterized by low consumption of all food groups). In the multivariable-adjusted logistic regression model, compared with the Healthy-DP, women adhering to the Western-DP had significantly higher odds of being classified into the Severe-PMS group (OR:2.35, 95%CI:1.02-5.44). Similarly, those following the Low-food-DP had higher odds of both Moderate-PMS (OR:2.92, 95%CI:1.09-7.84) and Severe-PMS (OR:3.01, 95% CI:1.14-7.92). These findings highlight potential associations between dietary patterns and PMS severity; however, due to the cross-sectional design of the study, no causal conclusions can be drawn. CI - (c) 2026. The Author(s). FAU - Granda, Dominika AU - Granda D AD - Department of Nutrition Physiology, Institute of Sport, National Research Institute, Trylogii 2/16, Warsaw, 01-982, Poland. dominika.granda@insp.pl. AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), Nowoursynowska 166, Warsaw, 02-787, Poland. dominika.granda@insp.pl. FAU - Szmidt, Maria Karolina AU - Szmidt MK AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), Nowoursynowska 166, Warsaw, 02-787, Poland. maria_szmidt@sggw.edu.pl. FAU - Jarmuzek-Orska, Patrycja AU - Jarmuzek-Orska P AD - Department of Gynecology and Obstetrics with Gynecologic Oncology, Ludwik Rydygier Memorial Specialized Hospital, Zlotej Jesieni 1, Cracow, 31-826, Poland. FAU - Kaluza, Joanna AU - Kaluza J AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), Nowoursynowska 166, Warsaw, 02-787, Poland. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260615 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - *Premenstrual Syndrome/epidemiology/etiology MH - Cross-Sectional Studies MH - Adult MH - Young Adult MH - Adolescent MH - *Diet/adverse effects MH - Europe/epidemiology MH - *Feeding Behavior MH - Surveys and Questionnaires PMC - PMC13530195 OTO - NOTNLM OT - Cluster analysis OT - Diet OT - Dietary patterns OT - Nutrition OT - Premenstrual syndrome OT - Premenstrual syndrome screening tool COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/06/16 00:33 MHDA- 2026/09/01 05:41 PMCR- 2026/06/15 CRDT- 2026/06/15 23:37 PHST- 2025/10/23 00:00 [received] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/09/01 05:41 [medline] PHST- 2026/06/16 00:33 [pubmed] PHST- 2026/06/15 23:37 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.1038/s41598-026-58236-0 [pii] AID - 58236 [pii] AID - 10.1038/s41598-026-58236-0 [doi] PST - epublish SO - Sci Rep. 2026 Jun 15;16(1):27317. doi: 10.1038/s41598-026-58236-0. PMID- 28520347 STAT- Publisher DRDT- 20260616 CTDT- 20120308 PB - National Center for Biotechnology Information (US) DP - 2012 TI - Warfarin Therapy and VKORC1 and CYP Genotype. BTI - Medical Genetics Summaries AB - Warfarin (brand name Coumadin) is an anticoagulant (blood thinner). Warfarin acts by inhibiting the synthesis of vitamin K-dependent clotting factors II, VII, IX and X, and is used in the prevention and treatment of various thrombotic disorders (1). Warfarin is a drug with narrow therapeutic index; thus, a small change in its plasma levels can result in concentration-dependent adverse drug reactions or therapeutic failure. As such, the therapeutic dose of warfarin must be tailored for each individual based on response, which is measured by the INR (International Normalized Ratio), and the condition being treated (1). There is a wide inter-individual variability -up to twenty-fold-in the dose of warfarin required to achieve therapeutic anticoagulation, and the time it takes to reach target INR. Approximately half of this variability is caused by both clinical or lifestyle factors (for example, an individual's age, body mass index, gender, diet, smoking status, ethnicity/race, existing conditions, and concomitant medications) and by genetic variants in the VKORC1, CYP2C9 and CYP4F2 genes, and the CYP2C gene cluster rs12777823 variant (1). The VKORC1 and CYP2C9 variants are the most important known genetic determinants of warfarin dosing. Warfarin targets VKORC1, an enzyme involved in vitamin K recycling. A common VKORC1 variant, c.-1639G>A, is associated with warfarin sensitivity and lower dose requirements. The CYP2C9 enzyme metabolizes S-warfarin, the more potent stereoisomer, and CYP2C9 variants with reduced activity are also associated with lower dose requirements (2). The FDA-approved drug label for warfarin states that CYP2C9 and VKORC1 genotype information, when available, can assist in the selection of the initial and maintenance dose of warfarin. The label provides 2 sets of warfarin dosing recommendations, for when the CYP2C9 and VKORC1 genotypes are either known (Table 1) or not known (taking into account clinical factors, the initial dose of warfarin is usually 2-5 mg once daily and maintenance doses are typically 2-10 mg daily) (1). The 2017 Update of the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing provides warfarin dosing recommendations for adults and pediatric individuals. Recommendations from CPIC state that these dosing guidelines are applied after a warfarin dose has been calculated using a validated pharmacogenetic algorithm, which includes genotype information for VKORC1, c.-1639G>A and CYP2C9 (Figure 1) (2). More recently, the Dutch Pharmacogenetics Working Group (DPWG) of the Royal Dutch Association for the Advancement of Pharmacy (KNMP) has published recommendations for the initial standard dose of warfarin (3). A dose reduction is recommended for individuals who are CYP2C9 poor (PM) and intermediate metabolizers (IM) (with the exception of IM with the CYP2C9*1/*2 genotype, no dose change is required), and a dose reduction is recommended for individuals who have 2 copies of the VKORC1 c.-1639G>A variant allele (c.-1639G>A/A) (Table 2) (4, 5). In addition, genetic variation in the CYP4F2 gene and a variant near the CYP2C gene cluster, rs12777823, have been associated with warfarin dosing. The CYP4F2*3 variant is associated with a modest increase in warfarin dose requirements, notably in individuals with European or Asian ancestry who are more likely to have this variant allele than other ancestral populations. Individuals with African ancestry are more likely than other ancestral groups to have the rs12777823 A/G or A/A genotype that has been associated with decreased warfarin dose requirements. FAU - Dean, Laura AU - Dean L AD - NCBI FAU - Kane, Megan AU - Kane M AD - NCBI LA - eng PT - Review PT - Book Chapter PL - Bethesda (MD) OTO - NLM OT - Warfarin OT - warfarin therapy OT - Coumadin OT - warfarin response OT - coumadin response OT - anticoagulation OT - blood thinner OT - VKORC1 OT - CYP2C9 OT - CYP4F2 OT - INR EDAT- 2026/06/16 00:00 CRDT- 2026/06/16 00:00 AID - NBK84174 [bookaccession] PMID- 42295709 OWN - NLM STAT- MEDLINE DCOM- 20260615 LR - 20260813 IS - 0971-5916 (Print) IS - 0971-5916 (Linking) VI - 163 IP - 6 DP - 2026 Jun TI - Household food insecurity in urban slums and its association with nutritional status of under-five children in Salem District, Tamil Nadu. PG - 838-846 LID - 10.25259/IJMR_2123_2025 [pii] AB - Background and objectives Household food security is defined as physical and economic access to sufficient, safe, and nutritious food for an active and healthy life. Evidence suggests that urban poor are more food insecure (51%-Delhi and 74.6%-Vellore) than rural poor. Food insecurity adversely affects under-five children's nutritional status. This study aimed to assess prevalence, determinants, and its association with child-nutrition in urban slums of Salem district, Tamil Nadu. Methods A community-based cross-sectional study was conducted among 363 randomly selected households between January to September 2023 using multi-stage random sampling. Data were collected from primary-care-givers using a validated-semi-structured-questionnaire (USAID-HFIAS) followed by measurement of daily raw food consumption and anthropometry of under-five children. Statistical analysis was performed in SPSSv16.0 using Chi-square/Fisher's test, ANOVA and regression with P<0.05 taken as significant. Results Household food insecurity prevalence was 82.1%, with 20.1% severe. Mean food consumption was significantly lower among insecure households. Determinants included age/gender of household head, single earning member, dependents, and irregular use of public distribution system. Children with normal nutrition had 2.75 [P<0.05;95% confidence interval (C.I):1.31-5.75] times odds of belonging to secure households. Interpretation and conclusions Food insecurity was closely linked to under-five malnutrition, underscoring the need for interventions addressing affordability and structural factors such as housing, healthcare access, and resource distribution. FAU - Arumugam, Daivik Padmavathi AU - Arumugam DP AD - Department of Community Medicine, Government Namakkal Medical College, Chennai, Tamil Nadu, India. FAU - Ramasamy, Umamaheswari AU - Ramasamy U AD - Institute of Community Medicine, Madras Medical College, Chennai, Tamil Nadu, India. LA - eng PT - Journal Article PL - United States TA - Indian J Med Res JT - The Indian journal of medical research JID - 0374701 SB - IM MH - Humans MH - *Food Insecurity MH - *Nutritional Status MH - Female MH - India/epidemiology MH - Poverty Areas MH - Child, Preschool MH - Male MH - Infant MH - Urban Population MH - Cross-Sectional Studies MH - Family Characteristics MH - Food Supply MH - Rural Population MH - Poverty MH - Malnutrition/epidemiology MH - Socioeconomic Factors PMC - PMC13289621 OTO - NOTNLM OT - Food insecurity OT - Nutritional status OT - Preschool OT - Socio-economic factors OT - Urban population COIS- None. EDAT- 2026/06/15 12:55 MHDA- 2026/06/15 12:56 PMCR- 2026/06/01 CRDT- 2026/06/15 11:22 PHST- 2025/08/11 00:00 [received] PHST- 2025/12/23 00:00 [accepted] PHST- 2026/06/15 12:56 [medline] PHST- 2026/06/15 12:55 [pubmed] PHST- 2026/06/15 11:22 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - 10.25259/IJMR_2123_2025 [pii] AID - 10.25259/IJMR_2123_2025 [doi] PST - ppublish SO - Indian J Med Res. 2026 Jun;163(6):838-846. doi: 10.25259/IJMR_2123_2025. PMID- 42295494 OWN - NLM STAT- MEDLINE DCOM- 20260615 LR - 20260922 IS - 1573-2649 (Electronic) IS - 0962-9343 (Print) IS - 0962-9343 (Linking) VI - 35 IP - 8 DP - 2026 Jun 15 TI - Trends in cardiometabolic disease and health-related quality of life in the United States, 2001-2022. LID - 10.1007/s11136-026-04300-1 [doi] LID - 195 AB - PURPOSE: To examine associations between cardiometabolic conditions and health-related quality of life (HRQoL) and evaluate temporal trends in condition-associated HRQoL decrements from 2001 to 2022. METHODS: We analyzed nationally representative data from U.S. adults aged >/= 18 years in the Medical Expenditure Panel Survey (2001-2022), excluding years without BMI data collection (2017, 2019, 2021). HRQoL was measured using EQ-5D utilities mapped from SF-12 scores with a validated algorithm. For each year, survey-weighted multivariable regression models estimated associations of sociodemographic characteristics, BMI, and six cardiometabolic conditions with HRQoL. Temporal trends in condition-associated HRQoL decrements were assessed using meta-regression. To estimate recent average associations, we pooled data from 2015, 2016, 2018, and 2022. RESULTS: HRQoL improved over time, with lower values in 2001-2012 than 2013-2022 and an increase from its lowest value in 2012 (0.873) to highest in 2018 (0.888). Stroke contributed the greatest adjusted HRQoL decrement, followed by heart disease, diabetes, high blood pressure, obesity, and high cholesterol. Diabetes- and heart disease-associated decrements attenuated linearly over time (-0.0500 in 2001 to -0.0414 in 2022 and -0.0611 to -0.0487, respectively) , whereas high blood pressure-associated decrement was greatest around 2012 (-0.0361 in 2001, -0.0404 in 2012, and - 0.0313 in 2022) and obesity-associated decrement was smallest around 2012 (- 0.0311, - 0.0290, and - 0.0370). CONCLUSIONS: Changes in condition-associated HRQoL decrements over time suggest that utility values may not remain constant across calendar years. Smaller decrements for diabetes and heart disease may reflect better treatment and management, whereas the growing obesity-related decrement may indicate changes in the national severity of obesity. These patterns highlight the need for current, nationally representative utility estimates in population health research. CI - (c) 2026. The Author(s). FAU - Yang, Danwei AU - Yang D AUID- ORCID: 0000-0003-3858-4673 AD - Department of Public Health Sciences, University of Chicago, Chicago, IL, USA. FAU - Kim, David D AU - Kim DD AUID- ORCID: 0000-0002-3383-8972 AD - Department of Public Health Sciences, University of Chicago, Chicago, IL, USA. David.Kim@bsd.uchicago.edu. AD - Department of Medicine, University of Chicago, Chicago, IL, USA. David.Kim@bsd.uchicago.edu. LA - eng GR - R01 MD019094/MD/NIMHD NIH HHS/United States GR - R01MD019094/NH/NIH HHS/United States PT - Journal Article DEP - 20260615 PL - Netherlands TA - Qual Life Res JT - Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation JID - 9210257 SB - IM MH - Humans MH - *Quality of Life MH - United States/epidemiology MH - Female MH - Middle Aged MH - Adult MH - Male MH - *Cardiovascular Diseases/epidemiology MH - Aged MH - *Health Status MH - Young Adult MH - Body Mass Index MH - Adolescent MH - Obesity/epidemiology MH - Surveys and Questionnaires PMC - PMC13269321 OAB - Cardiometabolic conditions such as diabetes, heart disease, stroke, high blood pressure, obesity, and high cholesterol are common chronic diseases in the United States and can reduce health-related quality of life. However, it is unclear whether their impact on health-related quality of life has changed over time as disease management and treatment have improved. Using nationally representative survey data from U.S. adults collected between 2001 and 2022, we estimated how much each cardiometabolic condition reduced health-related quality of life and whether the condition-specific estimates have changed over time. Overall health-related quality of life improved between 2001 and 2022, with the greatest gains among older adults. Stroke had the largest negative impact on health-related quality of life, followed by heart disease, diabetes, high blood pressure, obesity, and high cholesterol. The health-related quality-of-life gap between adults with and without diabetes or heart disease has narrowed over time, a pattern consistent with improved disease management and treatment. In contrast, the quality-of-life gap associated with obesity increased in recent years, a pattern consistent with the rise in severe obesity nationally. Researchers and policymakers may use up to date quality of life estimates rather than older figures when evaluating the burden of cardiometabolic disease. Using updated disease-attributable health-related quality of life estimates would better reflect the current burden of cardiometabolic disease. OABL- eng OTO - NOTNLM OT - Cardiometabolic diseases OT - EQ-5D OT - Health-related quality of life (HRQoL) OT - Temporal trends COIS- Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: This study used de-identified, publicly available data from the Medical Expenditure Panel Survey, which is conducted by the Agency for Healthcare Research and Quality. No identifiable human subjects data were used. Consent to participate: Not applicable. Consent for publication: Not applicable. Preprint server: A previous version of this manuscript was posted on medRxiv as a preprint. The current manuscript has been revised in response to peer-review comments and differs from the posted preprint. DOI: 10.64898/2026.02.20.26346754. EDAT- 2026/06/15 12:52 MHDA- 2026/06/15 12:53 PMCR- 2026/06/15 CRDT- 2026/06/15 11:18 PHST- 2026/04/01 00:00 [received] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/06/15 12:53 [medline] PHST- 2026/06/15 12:52 [pubmed] PHST- 2026/06/15 11:18 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.1007/s11136-026-04300-1 [pii] AID - 4300 [pii] AID - 10.1007/s11136-026-04300-1 [doi] PST - epublish SO - Qual Life Res. 2026 Jun 15;35(8):195. doi: 10.1007/s11136-026-04300-1. PMID- 42295221 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20261008 IS - 1939-134X (Electronic) IS - 1040-3590 (Linking) VI - 38 IP - 10 DP - 2026 Oct TI - Maladaptive exercise: A psychometric investigation. PG - 716-728 LID - 10.1037/pas0001479 [doi] AB - There are multiple conceptualizations of maladaptive exercise with each being assessed by different measures. This has led to challenges in integrating the literature. Better understanding of the underlying processes of maladaptive exercise is needed to better conceptualize the construct. The present study used data from two independent samples, a college student sample (n = 497), identified primarily as female (72%), male (22%), White (38%), and Black (22%), and a sample recruited for their exercise engagement (n = 500), identified primarily as female (41%), male (56%), White (57%), and Black (20%). All participants completed self-report measures, including measures of maladaptive exercise (i.e., the Exercise Dependence Scale-Revised, Exercise Addiction Inventory-3, and Compulsive Exercise Test) and assessments of focal criterion variables for the problematic behavior (i.e., impulsivity, compulsivity, and eating disorder pathology). We used exploratory factor analysis to examine the overlapping and distinct content across measures of maladaptive exercise. We then examined correlations between the focal criterion variables and the measures of maladaptive exercise and latent factors. In both samples, the exploratory factor analysis suggested a four-factor solution reflecting tolerance and structure, impairment, exercise worries, and affect regulation. Our findings highlight the overlapping and distinct qualities of the varying assessment instruments and how those qualities map onto the potential underlying processes of maladaptive exercise. Future work should continue to refine the features of a broad definition of maladaptive exercise and develop a self-report measure that integrates the content from the existing measures. (PsycInfo Database Record (c) 2026 APA, all rights reserved). FAU - Schleyer, Brooke AU - Schleyer B AUID- ORCID: 0009-0008-0375-0487 AD - Department of Psychology and Neuroscience, Temple University. FAU - Olino, Thomas M AU - Olino TM AUID- ORCID: 0000-0001-5139-8571 AD - Department of Psychology and Neuroscience, Temple University. LA - eng PT - Journal Article DEP - 20260615 PL - United States TA - Psychol Assess JT - Psychological assessment JID - 8915253 SB - IM MH - Humans MH - Female MH - Male MH - Psychometrics MH - Young Adult MH - *Exercise/psychology MH - Adult MH - Adolescent MH - Factor Analysis, Statistical MH - *Behavior, Addictive/psychology/diagnosis MH - *Feeding and Eating Disorders/psychology MH - Impulsive Behavior MH - Compulsive Exercise MH - Self Report MH - Students/psychology EDAT- 2026/06/15 12:52 MHDA- 2026/09/21 17:47 CRDT- 2026/06/15 11:03 PHST- 2026/09/21 17:47 [medline] PHST- 2026/06/15 12:52 [pubmed] PHST- 2026/06/15 11:03 [entrez] AID - 2027-83726-001 [pii] AID - 10.1037/pas0001479 [doi] PST - ppublish SO - Psychol Assess. 2026 Oct;38(10):716-728. doi: 10.1037/pas0001479. Epub 2026 Jun 15. PMID- 42293103 OWN - NLM STAT- In-Process DCOM- 20260615 LR - 20260828 IS - 1664-2295 (Print) IS - 1664-2295 (Electronic) IS - 1664-2295 (Linking) VI - 17 DP - 2026 TI - Highlighting the value of polymyography in childhood onset movement disorders. PG - 1771878 LID - 10.3389/fneur.2026.1771878 [doi] LID - 1771878 AB - INTRODUCTION: Characterizing hyperkinetic Movement Disorders (MD) in children is challenging, particularly when distinguishing tremor from myoclonus. Polymyography (EMG combined with accelerometry) and EEG jerk-locked back-averaging are well-established diagnostic tools in adults but are rarely applied in paediatric population. This study aimed to assess the feasibility and contribution of individualized neurophysiological investigations to the classification of hyperkinetic MD in children. MATERIALS AND METHODS: We retrospectively reviewed clinical and neurophysiological data from consecutive patients who underwent polymyography over a two-year period being referred for unclear clinical MD phenomenology. A pediatric MD specialist and a neurophysiologist jointly performed evaluations. RESULTS: 56/60 patients were included (four were excluded due to absent MD during recording or lack of cooperation). Myoclonus was the most frequent polymyography diagnosis (55%), followed by tremor (36%). Initial clinical diagnoses were confirmed in 62% of cases: all suspected cases of myoclonus were validated, whereas 48% patients initially diagnosed with tremor were reclassified as having myoclonus. Polymyography revealed additional MD in 18% of patients, most often myoclonus, and supported a neurofunctional aetiology in one case. After the polymyography, symptomatic pharmacological treatment-mainly for tremor and cortical myoclonus-was proposed in 34%. Additional genetic investigations were suggested in 30% of patients. DISCUSSION AND CONCLUSION: Polymyography proved feasible even in young children, including those with intellectual disability. Combined with expertise of an MD specialist, polymyography significantly improves diagnostic accuracy, particularly tremor vs. myoclonus, and guides both aetiologic and therapeutic management. These findings highlight the value of integrating polymyography into paediatric MD evaluation. CI - Copyright (c) 2026 Moretti, Ravelli, Ahmar, Dorison, De Salins, Rodriguez, Deiva, Vermersch, Triboulet, Valence, Harion, Burglen, Apartis and Doummar. FAU - Moretti, Raffaella AU - Moretti R AD - Department of Clinical Neurophysiology, Armand Trousseau Hospital, AP-HP-Sorbonne Universite, Paris, France. FAU - Ravelli, Claudia AU - Ravelli C AD - Department of Paediatric Neurology, Armand Trousseau Hospital, Referral Centre for Neurogenetic Rare Disease, APHP-Sorbonne Universite, Paris, France. FAU - Ahmar, Yara AU - Ahmar Y AD - Department of Clinical Neurophysiology, Saint-Antoine Hospital and Pitie-Salpetriere Hospital, APHP-Sorbonne Universite, Paris, France. FAU - Dorison, Nathalie AU - Dorison N AD - Unite Dyspa, Neurochirurgie Pediatrique, Hopital Fondation Rothschild, Paris, France. FAU - De Salins, Marie AU - De Salins M AD - Department of Clinical Neurophysiology, Armand Trousseau Hospital, AP-HP-Sorbonne Universite, Paris, France. FAU - Rodriguez, Diana AU - Rodriguez D AD - Department of Paediatric Neurology, Armand Trousseau Hospital, Referral Centre for Neurogenetic Rare Disease, APHP-Sorbonne Universite, Paris, France. AD - Sorbonne University, Paris, France. FAU - Deiva, Kumaran AU - Deiva K AD - Sorbonne University, Paris, France. AD - Department of Paediatric Neurology, Armand Trousseau Hospital, AP-HP Sorbonne University Hospital, Paris, France. FAU - Vermersch, Anne Isabelle AU - Vermersch AI AD - Department of Clinical Neurophysiology, Armand Trousseau Hospital, AP-HP-Sorbonne Universite, Paris, France. FAU - Triboulet, Minh Hanh AU - Triboulet MH AD - Department of Clinical Neurophysiology, Armand Trousseau Hospital, AP-HP-Sorbonne Universite, Paris, France. AD - Department of Paediatric Neurology, Armand Trousseau Hospital, AP-HP Sorbonne University Hospital, Paris, France. FAU - Valence, Stephanie AU - Valence S AD - Service de Neurologie Pediatrique, Hopital Armand Trousseau, AP-HP Sorbonne Universite, Paris, France. AD - Centre de Reference Maladies Rares "Deficience Intellectuelle de Cause Rare et Polyhandicap", Paris, France. FAU - Harion, Madeleine AU - Harion M AD - Service de Neurologie Pediatrique, Hopital Armand Trousseau, AP-HP Sorbonne Universite, Paris, France. AD - Centre de Reference Maladies Rares "Deficience Intellectuelle de Cause Rare et Polyhandicap", Paris, France. FAU - Burglen, Lydie AU - Burglen L AD - Sorbonne University, Paris, France. AD - Centre de Reference des Malformations et Maladies Congenitales du Cervelet et Laboratoire de Neurogenetique Pediatrique, Departement de genetique, Hopital Armand Trousseau, Paris, France. FAU - Apartis, Emmanuelle AU - Apartis E AD - Department of Clinical Neurophysiology, Saint-Antoine Hospital and Pitie-Salpetriere Hospital, APHP-Sorbonne Universite, Paris, France. AD - Paris Brain Institute, ICM, Inserm, CNRS, Sorbonne Universite, Paris, France. FAU - Doummar, Diane AU - Doummar D AD - Department of Paediatric Neurology, Armand Trousseau Hospital, Referral Centre for Neurogenetic Rare Disease, APHP-Sorbonne Universite, Paris, France. LA - eng PT - Journal Article DEP - 20260528 PL - Switzerland TA - Front Neurol JT - Frontiers in neurology JID - 101546899 PMC - PMC13253225 OTO - NOTNLM OT - childhood OT - dystonia OT - myoclonus OT - neurophysiology OT - paediatric movement disorders OT - polymyography OT - tremor COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor VL declared a past co-authorship with the authors CR and ND. EDAT- 2026/06/15 12:54 MHDA- 2026/06/15 12:55 PMCR- 2026/05/28 CRDT- 2026/06/15 07:35 PHST- 2025/12/19 00:00 [received] PHST- 2026/04/02 00:00 [revised] PHST- 2026/05/06 00:00 [accepted] PHST- 2026/06/15 12:55 [medline] PHST- 2026/06/15 12:54 [pubmed] PHST- 2026/06/15 07:35 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - 10.3389/fneur.2026.1771878 [doi] PST - epublish SO - Front Neurol. 2026 May 28;17:1771878. doi: 10.3389/fneur.2026.1771878. eCollection 2026. PMID- 42292924 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 2377-9608 (Electronic) IS - 2377-9608 (Linking) VI - 12 DP - 2026 Jan-Dec TI - Innovations in Pediatric Nursing: Emerging Technologies Including Virtual Reality, Telehealth, Artificial Intelligence, and Digital Mental Health-A Scoping Review. PG - 23779608261433684 LID - 10.1177/23779608261433684 [doi] LID - 23779608261433684 AB - BACKGROUND: Pediatric nursing is rapidly evolving with the integration of innovative technologies aimed at improving healthcare delivery and outcomes for children. OBJECTIVES: To map the extent and characteristics of pediatric nursing literature on (1) virtual reality (VR) for procedural care, (2) telehealth models, (3) artificial intelligence (AI)-supported diagnostics, (4) technology-enabled obesity interventions, and (5) digital mental-health tools; and to identify outcomes studied, populations/settings, study designs, and research gaps. METHODS: A scoping review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines was conducted. Peer-reviewed articles published from 2010 to 2024 were retrieved from PubMed, CINAHL, Scopus, Cochrane Library, and Google Scholar. Inclusion criteria were studies involving pediatric populations and addressing one of the specified technologies or interventions. RESULTS: Twenty-five studies were included. VR was effective in reducing procedural pain and anxiety. Telehealth improved care access, especially in underserved areas. AI-supported early diagnosis of diseases such as congenital heart defects. Nursing interventions for childhood obesity were most effective when multidisciplinary and personalized. Digital tools helped pediatric patients manage mental health conditions associated with chronic illness. However, gaps exist in long-term effectiveness, scalability, and integration. CONCLUSIONS: Emerging technologies in pediatric nursing offer substantial benefits but require further validation and structured implementation. Future research should focus on standardizing protocols, assessing cost-effectiveness, and addressing equity in access. CI - (c) The Author(s) 2026. FAU - Mohamed, Shimmaa Mansour Moustafa AU - Mohamed SMM AUID- ORCID: 0000-0002-2956-610X AD - Department of Nursing, College of Applied Medical Sciences, University of Bisha, Bisha, Saudi Arabia. RINGGOLD: 488770 LA - eng PT - Journal Article PT - Review DEP - 20260612 PL - United States TA - SAGE Open Nurs JT - SAGE open nursing JID - 101724853 PMC - PMC13263502 OTO - NOTNLM OT - children OT - new graduate/graduate nurse OT - pediatrics OT - scoping review COIS- The author declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/06/15 12:50 MHDA- 2026/06/15 12:51 PMCR- 2026/06/12 CRDT- 2026/06/15 07:33 PHST- 2025/08/05 00:00 [received] PHST- 2026/02/27 00:00 [revised] PHST- 2026/03/02 00:00 [accepted] PHST- 2026/06/15 12:51 [medline] PHST- 2026/06/15 12:50 [pubmed] PHST- 2026/06/15 07:33 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - 10.1177_23779608261433684 [pii] AID - 10.1177/23779608261433684 [doi] PST - epublish SO - SAGE Open Nurs. 2026 Jun 12;12:23779608261433684. doi: 10.1177/23779608261433684. eCollection 2026 Jan-Dec. PMID- 42291859 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 5 DP - 2026 May TI - Caregiver Feeding Practices and Their Association With Nutritional Status in Children Aged 0-5 Years: A Descriptive Cross-Sectional Study From a Tertiary Care Center in North India. PG - e108756 LID - 10.7759/cureus.108756 [doi] LID - e108756 AB - Background Adequate nutrition in the first five years of life is critical for optimal physical growth, cognitive development, and long-term health outcomes. Caregiver feeding practices are an important factor associated with nutritional outcomes in young children with a spectrum of behaviors ranging from responsive feeding to more controlling strategies. While responsive feeding has been linked to better growth outcomes, the impact of specific feeding behaviors on child nutritional status in tertiary pediatric settings in North India remains poorly characterized. Therefore, this study aimed to evaluate caregiver feeding practices using a validated tool and examine their association with nutritional status in children aged 0-5 years. Objectives The objective of this study is to assess caregiver feeding practices using the Feeding Practices and Structure Questionnaire (FPSQ) and examine their association with nutritional status (Indian Academy of Pediatrics IAP grading) in children aged 0-5 years attending the outpatient department of a tertiary care pediatric center, in order to identify feeding behaviors associated with malnutrition in this setting. Materials and methods A descriptive cross-sectional study was carried out over a period of three months in the outpatient department of pediatrics at Christian Medical College, Ludhiana. A total of 150 caregivers of children aged 0-5 years were enrolled. After obtaining informed consent, each caregiver was administered a structured questionnaire (Feeding Practices and Structure Questionnaire FPSQ), which is a validated tool assessing both feeding practices and feeding patterns. Simultaneously, anthropometric measurements of the children were recorded, and their nutritional status was classified using the Indian Academy of Pediatrics (IAP) grading system. The collected data were analyzed to assess the association between feeding behavior and nutritional status. Results Out of 150 children, 83.3% were normally nourished, 16% had mild malnutrition, and 0.7% had moderate malnutrition. Responsive feeding behaviors such as feeding on demand and shared family meals were the most commonly reported practices. In the milk-feeding group, feeding on demand showed a significant association with better nutritional status (p = 0.015). In the semi-solid group, parent-led feeding was significantly associated with malnutrition (p = 0.008). Conclusion Feeding on demand was associated with better nutritional outcomes in milk-fed children, while parent-led feeding was associated with malnutrition in the semi-solid-feeding group. These findings are hypothesis-generating, given the cross-sectional design, and reverse causality cannot be excluded. Responsive feeding counseling may be a relevant avenue for nutritional improvement in routine pediatric outpatient care. CI - Copyright (c) 2026, John et al. FAU - John, Sharon R AU - John SR AD - Pediatrics and Child Health, Christian Medical College and Hospital, Ludhiana, Ludhiana, IND. FAU - Singh, Ruby AU - Singh R AD - Pediatrics and Child Health, Christian Medical College and Hospital, Ludhiana, Ludhiana, IND. LA - eng PT - Journal Article DEP - 20260512 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13260016 OTO - NOTNLM OT - anthropometry OT - caregivers' influence OT - children OT - feeding pattern OT - malnutrition COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. The Institutional Ethics Committee of Christian Medical College, Ludhiana, issued approval IECBMHR/202411-506/Apprvl-STS-Proj/CMC&H. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/06/15 12:50 MHDA- 2026/06/15 12:51 PMCR- 2026/05/12 CRDT- 2026/06/15 07:23 PHST- 2026/04/02 00:00 [received] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/06/15 12:51 [medline] PHST- 2026/06/15 12:50 [pubmed] PHST- 2026/06/15 07:23 [entrez] PHST- 2026/05/12 00:00 [pmc-release] AID - 10.7759/cureus.108756 [doi] PST - epublish SO - Cureus. 2026 May 12;18(5):e108756. doi: 10.7759/cureus.108756. eCollection 2026 May. PMID- 42291790 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 2667-3681 (Electronic) IS - 2667-3681 (Linking) VI - 19 DP - 2026 Sep TI - Development of program requirements for obesity medicine fellowship training in the U.S. PG - 100282 LID - 10.1016/j.obpill.2026.100282 [doi] LID - 100282 AB - BACKGROUND: Subspecialty fellowship training programs typically adhere to program requirements for graduate medical education for their field, which are established by accreditation organizations. However, US-based obesity medicine fellowships currently lack this guidance. Therefore, our objective was to develop and validate subspecialty fellowship program requirements for both adult and pediatric obesity medicine in the US. METHODS: A work group from the Obesity Medicine Fellowship Council (OMFC) was convened to define program requirements for obesity medicine (OM) fellowships, including standards for curricular and clinical experiences during training. Draft program requirements for adult OM and pediatric OM fellowships were developed through an iterative consensus group process with repeated cycles of drafting and revising by an expert work group who then gained input from the American Board of Obesity Medicine and leadership from all OMFC-recognized fellowship programs. The draft documents were subsequently revised and then validated through a national survey to all US-based OM fellowship programs, where adult OM fellowships evaluated the adult OM program requirements and pediatric OM fellowships evaluated the pediatric OM program requirements. Respondents were asked to 'approve'/'not approve' each proposed section with space for comments. An agreement of at least 75% among respondents was set as the threshold a priori for retaining a program requirement. RESULTS: Representatives from all adult and pediatric OM fellowship programs participated in the survey (n = 31). All items met the minimum threshold of >/=75% approving the requirement for both adult and pediatric OM fellowship programs. Comments for revisions on specific elements were primarily related to changes in language and formatting rather than conceptual underpinnings. CONCLUSION: A group consensus method strengthened by inclusion of a national survey of OM fellowship program directors resulted in carefully-developed and broadly-vetted program requirements. These OM fellowship program requirements offer educators and trainees a roadmap to develop comprehensive OM training. CI - (c) 2026 The Authors. FAU - Schmidt, Stacy L AU - Schmidt SL AD - Obesity Medicine Fellowship Council, Denver, CO, USA. FAU - Sabet, Amin AU - Sabet A AD - University of Massachusetts Chan Medical School, Worcester, MA, USA. FAU - Wong, Denise H AU - Wong DH AD - Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. FAU - Gilden, Adam H AU - Gilden AH AD - University of Colorado School of Medicine, Aurora, CO, USA. FAU - Wickham, Edmond P AU - Wickham EP AD - Virginia Commonwealth University School of Medicine, Richmond, VA, USA. FAU - Raatz, Sarah AU - Raatz S AD - University of Minnesota Medical School, Minneapolis, MN, USA. FAU - Fox, Claudia K AU - Fox CK AD - University of Minnesota Medical School, Minneapolis, MN, USA. FAU - Gudzune, Kimberly A AU - Gudzune KA AD - Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. LA - eng PT - Journal Article DEP - 20260608 PL - United States TA - Obes Pillars JT - Obesity pillars JID - 9918697364706676 PMC - PMC13263674 OTO - NOTNLM OT - Clinical competence OT - Obesity management OT - Specialty boards COIS- The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Stacy Schmidt reports financial support was provided by Novo Nordisk Inc. Edmond P. Wickham 3rd reports a relationship with Novo Nordisk that includes: funding grants. Sarah Raatz reports a relationship with Novo Nordisk that includes: funding grants. Sarah Raatz reports a relationship with Eli Lilly and Company that includes: funding grants. Claudia K. Fox reports a relationship with Novo Nordisk Inc that includes: funding grants. Claudia K. Fox reports a relationship with Eli Lilly and Company that includes: funding grants. Amin Sabet reports a relationship with Abbott Laboratories that includes: equity or stocks. Amin Sabet reports a relationship with AbbVie that includes: equity or stocks. Amin Sabet reports a relationship with Eli Lilly and Company that includes: equity or stocks. Amin Sabet reports a relationship with Johnson and Johnson that includes: equity or stocks. Amin Sabet reports a relationship with Merck & Co Inc that includes: equity or stocks. Amin Sabet reports a relationship with Novo Nordisk that includes: equity or stocks. Kimberly A. Gudzune reports a relationship with Novo Nordisk Inc that includes: consulting or advisory, funding grants, and travel reimbursement. Kimberly A. Gudzune reports a relationship with Eli Lilly and Company that includes: consulting or advisory and travel reimbursement. Kimberly A. Gudzune has patent with royalties paid to Johns Hopkins ACG System. Given his role as an editor for Obesity Pillars, Amin Sabet had no involvement in the peer review of this article and had no access to information regarding its peer review. Full responsibility for the editorial process for this article was delegated to another journal editor. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/15 12:50 MHDA- 2026/06/15 12:51 PMCR- 2026/06/08 CRDT- 2026/06/15 07:22 PHST- 2026/05/06 00:00 [received] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/06/15 12:51 [medline] PHST- 2026/06/15 12:50 [pubmed] PHST- 2026/06/15 07:22 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - S2667-3681(26)00038-0 [pii] AID - 100282 [pii] AID - 10.1016/j.obpill.2026.100282 [doi] PST - epublish SO - Obes Pillars. 2026 Jun 8;19:100282. doi: 10.1016/j.obpill.2026.100282. eCollection 2026 Sep. PMID- 42290215 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261012 IS - 1098-108X (Electronic) IS - 0276-3478 (Linking) VI - 59 IP - 10 DP - 2026 Oct TI - Structural Validity of a Short Form of the Eating Disorder Examination Questionnaire in Adolescents Diagnosed With an Eating Disorder. PG - 2196-2206 LID - 10.1002/eat.70146 [doi] AB - OBJECTIVE: This study aimed to assess the structural validity and readability of a brief 7-item version of the Eating Disorder Examination Questionnaire (the EDE-Q7) among adolescents. METHOD: Latent variable analysis was used in a sample of 263 adolescents (age range = 13-17.99y) diagnosed with an eating disorder and recruited from treatment centres in the United States of America and Australia. Several indices were used to provide different estimates of overall model fit. RESULTS: The EDE-Q7 showed good fit to the data, although absolute fit indices suggested some evidence of imperfect fit. Several other models (both brief and full-item versions) failed to meet most criteria indicating good fit. The subscales of the EDE-Q7 showed significant correlations with several disordered eating behaviors, suggesting convergent validity. Review of the EDE-Q7 suggests ease of readability for adolescents from at least 11 years of age. DISCUSSION: This is one of the first clinical studies to support the EDE-Q7 as a brief, valid assessment of eating psychopathology that can be used with adolescents as well as adults. The results indicate that the EDE-Q7 might be appropriate for assessing eating pathology among adolescents from the age of 13 years. CI - (c) 2026 The Author(s). International Journal of Eating Disorders published by Wiley Periodicals LLC. FAU - Jenkins, Paul E AU - Jenkins PE AUID- ORCID: 0000-0003-1673-2903 AD - School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK. FAU - Gorrell, Sasha AU - Gorrell S AUID- ORCID: 0000-0002-8861-8547 AD - Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA. FAU - Accurso, Erin C AU - Accurso EC AUID- ORCID: 0000-0002-5521-6381 AD - Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA. AD - Philip R. Lee Institute for Health Policy Studies, University of California San Francisco, San Francisco, California, USA. FAU - Eckhardt, Sarah AU - Eckhardt S AUID- ORCID: 0000-0003-0824-4328 AD - Center for the Treatment of Eating Disorders, Children's Minnesota, St Paul, Minnesota, USA. FAU - Hughes, Elizabeth K AU - Hughes EK AUID- ORCID: 0000-0002-4377-5610 AD - Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia. AD - Murdoch Children's Research Institute, Parkville, Victoria, Australia. FAU - Le Grange, Daniel AU - Le Grange D AUID- ORCID: 0000-0001-7293-9496 AD - Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA. FAU - Sawyer, Susan M AU - Sawyer SM AUID- ORCID: 0000-0002-9095-358X AD - Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia. AD - Murdoch Children's Research Institute, Parkville, Victoria, Australia. AD - Centre for Adolescent Health, Royal Children's Hospital, Parkville, Victoria, Australia. FAU - Rienecke, Renee D AU - Rienecke RD AUID- ORCID: 0000-0003-0423-7403 AD - Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, Illinois, USA. LA - eng GR - Baker Foundation/ GR - Victorian Government's Operational Infrastructure Support Program/ GR - Goven Family Foundation/ PT - Journal Article PT - Validation Study DEP - 20260615 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM MH - Humans MH - Adolescent MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Surveys and Questionnaires/standards MH - Female MH - Reproducibility of Results MH - Psychometrics MH - Male MH - Australia OTO - NOTNLM OT - assessment OT - eating disorder examination-questionnaire OT - latent variable analysis OT - patient-reported outcome measures OT - psychometrics OT - readability EDAT- 2026/06/15 11:37 MHDA- 2026/10/12 11:41 CRDT- 2026/06/15 03:33 PHST- 2026/05/28 00:00 [revised] PHST- 2026/02/27 00:00 [received] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/10/12 11:41 [medline] PHST- 2026/06/15 11:37 [pubmed] PHST- 2026/06/15 03:33 [entrez] AID - 10.1002/eat.70146 [doi] PST - ppublish SO - Int J Eat Disord. 2026 Oct;59(10):2196-2206. doi: 10.1002/eat.70146. Epub 2026 Jun 15. PMID- 42289786 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260908 IS - 1463-1326 (Electronic) IS - 1462-8902 (Print) IS - 1462-8902 (Linking) VI - 28 IP - 9 DP - 2026 Sep TI - Phenotypic Heterogeneity of Obesity and Short-Term Cardiometabolic Risk Factors Transitions: A Population-Based Cohort Study. PG - 7931-7942 LID - 10.1111/dom.70998 [doi] AB - AIMS: Obesity in children is heterogeneous, but BMI-based risk stratification does not capture important differences in body composition or cardiometabolic risk factors. We aimed to develop a body composition-based obesity phenotyping framework and examine its associations with cardiometabolic risk factor transitions. MATERIALS AND METHODS: Utilising nine body composition metrics (whole-body and regional fat/muscle mass index, visceral fat area) from 2262 children with obesity in a training cohort, we applied the Discriminative Dimensionality Reduction Tree algorithm to construct a continuous two-dimensional phenotypic manifold. Modified Poisson regression and spatial autocorrelation analyses were used to evaluate associations between the mapped spatial dimensions and 2-year cardiometabolic risk factors transitions (progression and recovery). The topological framework was externally validated in an independent cohort of 330 children with obesity. RESULTS: Obesity phenotypes were mapped onto two principal axes to define three clinical profiles (mixed fat-muscle elevation, adiposity-dominant, and muscle-dominant), with their underlying structure consistently reproduced across external replication cohort. Dimension 1 was positively associated with progression to hypertension (RR = 1.18, 95% CI 1.09-1.28), high LDL-C (1.29, 1.13-1.49), and hyperuricemia (1.22, 1.13-1.30) and inversely with hypertension recovery (0.84, 0.76-0.92). Dimension 2 showed positive association with hypertension progression (1.27, 1.03-1.58) and inverse association with high LDL-C recovery (0.48, 0.23-0.96). DDRTree-derived dimensions showed no clear predictive advantage over BMI or body composition metrics in most analyses, suggesting the DDRTree manifold should be used for exploratory visualisation rather than clinical prediction. CONCLUSIONS: Phenotypic manifold mapping of childhood obesity identifies body composition subtypes with divergent short-term cardiometabolic risk trajectories. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Xiao, Pei AU - Xiao P AUID- ORCID: 0000-0001-9976-7655 AD - Center for Non-Communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Cheng, Hong AU - Cheng H AD - Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China. FAU - Hou, Dongqing AU - Hou D AD - Child Health Big Data Research Center, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Yan, Yinkun AU - Yan Y AUID- ORCID: 0000-0002-7758-744X AD - Center for Non-Communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Dong, Hongbo AU - Dong H AD - Center for Non-Communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Liu, Junting AU - Liu J AD - Child Health Big Data Research Center, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Liu, Li AU - Liu L AD - School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China. FAU - Li, Yan AU - Li Y AD - Child and Adolescent Chronic Disease Prevention and Control Department, Shenzhen Center for Chronic Disease Control, Shenzhen, China. FAU - Lan, Lina AU - Lan L AD - Child and Adolescent Chronic Disease Prevention and Control Department, Shenzhen Center for Chronic Disease Control, Shenzhen, China. FAU - Xiong, Jingfan AU - Xiong J AD - Child and Adolescent Chronic Disease Prevention and Control Department, Shenzhen Center for Chronic Disease Control, Shenzhen, China. FAU - Mi, Jie AU - Mi J AUID- ORCID: 0000-0003-0630-8447 AD - Center for Non-Communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. LA - eng GR - CFH2026-4G-2097/Capital's Funds for Health Improvement and Research/ GR - L259068/Beijing Natural Science Foundation/ GR - 82204061/National Natural Science Foundation of China/ GR - 82373589/National Natural Science Foundation of China/ GR - SZSM 202311020/Sanming Project of Medicine in Shenzhen/ PT - Journal Article DEP - 20260614 PL - England TA - Diabetes Obes Metab JT - Diabetes, obesity & metabolism JID - 100883645 SB - IM MH - Humans MH - Female MH - *Cardiometabolic Risk Factors MH - Male MH - Phenotype MH - *Obesity/complications/epidemiology MH - Child MH - Cohort Studies MH - Body Composition MH - Body Mass Index MH - Hypertension/epidemiology/etiology MH - Disease Progression MH - Adolescent MH - *Cardiovascular Diseases/epidemiology/etiology MH - Adiposity MH - Risk Factors MH - Hyperuricemia/epidemiology/etiology PMC - PMC13448869 OTO - NOTNLM OT - DDRTree OT - body composition OT - cardiometabolic risk factor OT - cohort study OT - obesity COIS- The authors declare no conflicts of interest. EDAT- 2026/06/15 11:37 MHDA- 2026/08/07 12:39 PMCR- 2026/08/07 CRDT- 2026/06/14 23:43 PHST- 2026/06/04 00:00 [revised] PHST- 2026/03/18 00:00 [received] PHST- 2026/06/04 00:00 [accepted] PHST- 2026/08/07 12:39 [medline] PHST- 2026/06/15 11:37 [pubmed] PHST- 2026/06/14 23:43 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - DOM70998 [pii] AID - 10.1111/dom.70998 [doi] PST - ppublish SO - Diabetes Obes Metab. 2026 Sep;28(9):7931-7942. doi: 10.1111/dom.70998. Epub 2026 Jun 14. PMID- 42288886 OWN - NLM STAT- MEDLINE DCOM- 20261006 LR - 20261007 IS - 1750-1172 (Electronic) IS - 1750-1172 (Linking) VI - 21 IP - 1 DP - 2026 Jun 13 TI - Disordered eating in diet-treated inborn errors of metabolism: screening and behavioral insights. LID - 10.1186/s13023-026-04420-4 [doi] LID - 338 AB - BACKGROUND: Lifelong restrictive diets are a mainstay of management for many inborn errors of metabolism (IEMs). The experience of metabolic care providers suggests higher prevalence of disordered eating behaviors in this population; however, this has not been well characterized. In this study, we applied screening tools adapted to our population to identify eating disorders and characterize associated symptomatology. All participants were given 2 assessment tools: the SCOFF questionnaire, a 5-question screen for a possible eating disorder, and a modified Eating Pathology Symptoms Inventory (EPSI), a 45-item Likert-scaled questionnaire characterizing eating disorder pathology. Patients aged 16 years and older on prescription diets at the Program for Inherited Metabolic Diseases at the Icahn School of Medicine at Mount Sinai were recruited. Participant demographics were collected through medical record review. RESULTS: Fifty-two subjects were enrolled, and 51 completed both surveys. 27 subjects identified as female (52%), 23 as male (44%), and two as genderqueer (4%). Ages ranged from 16 to 50 years old. The most common diagnosis was phenylketonuria (n = 34, 65%), followed by glycogen storage disease type 1a (n = 8, 15%). Most patients were on a low-protein diet (n = 41, 79%), 17% (n = 9) were on a low-carbohydrate diet, and 6% (n = 3) were on a low-fat diet. The SCOFF screen positive rate was 34.6%, 95% CI [22.0% - 49.1%], which is significantly greater than population norms of 10.1% (p < 0.001). EPSI results revealed that our participants were significantly more likely to demonstrate binge eating, restrictive behaviors, excessive exercise, and negative attitudes towards obesity when compared to population norms. CONCLUSION: This study demonstrates a significantly increased screen positive rate of likely eating disorders among patients with IEM, about three times that of the general population. Metabolic providers should be aware of this potential risk to their patients, as eating disorders can impact metabolic control and adherence to diet, while also causing significant psychological distress to patients with these rare disorders. These results demonstrate that heightened awareness of potential eating disorders in patients with IEMs is warranted, and the development of validated screening tools may be impactful to their care and management. CI - (c) 2026. The Author(s). FAU - LoPiccolo, Mary Kate AU - LoPiccolo MK AUID- ORCID: 0009-0004-0851-3107 AD - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. mary.lopiccolo@mssm.edu. FAU - Cinnamon, Claire AU - Cinnamon C AD - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Donnelly, Colleen AU - Donnelly C AD - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Ginevic, Ilona AU - Ginevic I AD - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Waite, Jessica AU - Waite J AD - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Donnelly, Sara AU - Donnelly S AD - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Ma, Mingyu AU - Ma M AD - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Staccone, Caroline AU - Staccone C AD - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Estrella, Lissette AU - Estrella L AD - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Weinberg, Alan AU - Weinberg A AD - Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Hildebrandt, Thomas AU - Hildebrandt T AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Breilyn, Margo Sheck AU - Breilyn MS AD - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. LA - eng PT - Journal Article DEP - 20260613 PL - England TA - Orphanet J Rare Dis JT - Orphanet journal of rare diseases JID - 101266602 SB - IM MH - Humans MH - Female MH - Male MH - Adult MH - Adolescent MH - *Feeding and Eating Disorders/diagnosis/etiology MH - Middle Aged MH - *Metabolism, Inborn Errors/diet therapy MH - Young Adult MH - Surveys and Questionnaires MH - Phenylketonurias/diet therapy PMC - PMC13637089 OTO - NOTNLM OT - Comorbidities OT - Eating disorder OT - Inborn errors of metabolism OT - Nutrition OT - Screening COIS- Declarations. Ethics approval and consent to participate: This study was performed in line with the principles of the declaration of Helsinki. Ethics and research governance approval were obtained from the Mount Sinai Institutional Review Board (IRB 21-01385). Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/06/15 11:29 MHDA- 2026/10/06 06:30 PMCR- 2026/06/13 CRDT- 2026/06/13 23:37 PHST- 2025/12/31 00:00 [received] PHST- 2026/05/22 00:00 [accepted] PHST- 2026/10/06 06:30 [medline] PHST- 2026/06/15 11:29 [pubmed] PHST- 2026/06/13 23:37 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - 10.1186/s13023-026-04420-4 [pii] AID - 4420 [pii] AID - 10.1186/s13023-026-04420-4 [doi] PST - epublish SO - Orphanet J Rare Dis. 2026 Jun 13;21(1):338. doi: 10.1186/s13023-026-04420-4. PMID- 42288871 OWN - NLM STAT- MEDLINE DCOM- 20260820 LR - 20260908 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jun 13 TI - Fidelity evaluation of the Water First intervention for promoting tap water consumption in school-age children. LID - 10.1186/s12889-026-28101-w [doi] LID - 2399 AB - BACKGROUND: A cluster-randomized controlled trial examining the impact of the Water First water promotion and access program in 18 elementary schools found that the intervention increased water consumption and prevented overweight. This study describes a secondary analysis of implementation fidelity and its association with change in students' beverage intake and body mass index (BMI) z-score in the intervention arm. METHODS: Researchers observed Water First fidelity (visible water promotional material, quality of study-provided water sources and drinking vessels in classrooms, school cafeterias, high-traffic areas) 2 times/week during the intervention period, with data collected via yes/no questions. Responses indicating high fidelity were assigned a value of 1 and low fidelity were assigned 0; these were averaged to generate a summary score for each location (0 to 1). Home-engagement activity completion (%) was calculated per student based on returned class assignments. Anthropometrics and past-week frequency of beverage intake (instrument adapted from the validated Beverage and Snack Questionnaire) were assessed at baseline, 7-months, and 15-months. Mixed-effects linear regression models examined associations of fidelity with the primary (water intake) and secondary (sugar-sweetened beverage [SSB], milk, 100% fruit juice intake, BMI z-score) outcomes. The primary predictor was the fidelity score (0.1-unit increase) by time interaction. Beverage frequencies were log-transformed, and regression coefficients were exponentiated to derive the percent change in outcomes. RESULTS: Fidelity was highest in the cafeteria (mean: 0.87, SD: 0.06) compared to high-traffic water station areas (0.66, SD: 0.15) and classrooms (0.73, SD: 0.13). Mean home-engagement activity completion rate was 0.41 (SD: 0.33). There were no associations of fidelity with water intake. Each 0.1 unit increase in classroom fidelity was associated with a decreased intake of 100% fruit juice (0.95; Cl: 0.91-0.99). Higher high-traffic area fidelity was associated with decreased intake of SSB (0.94; Cl: 0.91-0.98) and plain milk (0.92; Cl: 0.89-0.96). Higher cafeteria fidelity was associated with 0.027 decrease in BMI z-score (Cl: -0.046, -0.008). No significant associations were observed for home-engagement activity completion. CONCLUSIONS: The intervention was largely implemented with high fidelity, with scores ranging from 0.66 to 0.87. Higher cafeteria fidelity was associated with reductions in BMI z-score, while home-engagement activity completion was not associated with changes in beverage outcomes or BMI z-score. TRIAL REGISTRATION: The trial was preregistered (2017-06-09) at clinicaltrials.gov (NCT03181971). CI - (c) 2026. The Author(s). FAU - Gupta, Anjali AU - Gupta A AD - Stanford University School of Medicine, Stanford, CA, USA. FAU - Ryu, Keejeong AU - Ryu K AD - Quantitative Sciences Unit, Stanford University School of Medicine, Stanford, CA, USA. FAU - Peralta, Yadira AU - Peralta Y AD - Center for Research and Teaching in Economics, Department of Applied Economics, Aguascalientes, Mexico. FAU - Ordonez, Valeria AU - Ordonez V AD - Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA. FAU - McCulloch, Charles E AU - McCulloch CE AD - Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA. FAU - Schmidt, Laura A AU - Schmidt LA AD - Philip R. Lee Institute for Health Policy Studies and Department of Humanities and Social Sciences, University of California San Francisco, San Francisco, CA, USA. FAU - Ritchie, Lorrene D AU - Ritchie LD AD - Nutrition Policy Institute, Division of Agriculture and Natural Resources, University of California, Oakland, CA, USA. FAU - Patel, Anisha I AU - Patel AI AD - Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA. anipatel@stanford.edu. LA - eng SI - ClinicalTrials.gov/NCT03181971 GR - R01 HL129288/HL/NHLBI NIH HHS/United States GR - R01HL129288/National Heart, Lung, and Blood Institute of the National Institutes of Health/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20260613 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - 0 (Drinking Water) SB - IM MH - Humans MH - Child MH - Female MH - *Drinking Water MH - Male MH - *Health Promotion/methods MH - Beverages/statistics & numerical data MH - Body Mass Index MH - *Drinking MH - Schools MH - Program Evaluation MH - Overweight/prevention & control PMC - PMC13491641 OTO - NOTNLM OT - Beverages OT - Intervention fidelity OT - Obesity OT - Public health OT - Water COIS- Declarations. Ethics approval and consent to participate: This research was conducted in accordance with the Declaration of Helsinki. Signed informed parental consent and student assent were obtained for study participation. Institutional review boards at the University of California, San Francisco, and Stanford University approved study protocols. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/15 11:32 MHDA- 2026/08/20 05:43 PMCR- 2026/06/13 CRDT- 2026/06/13 23:37 PHST- 2025/02/27 00:00 [received] PHST- 2026/06/04 00:00 [accepted] PHST- 2026/08/20 05:43 [medline] PHST- 2026/06/15 11:32 [pubmed] PHST- 2026/06/13 23:37 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - 10.1186/s12889-026-28101-w [pii] AID - 28101 [pii] AID - 10.1186/s12889-026-28101-w [doi] PST - epublish SO - BMC Public Health. 2026 Jun 13;26(1):2399. doi: 10.1186/s12889-026-28101-w. PMID- 42288815 OWN - NLM STAT- MEDLINE DCOM- 20260731 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jun 13 TI - Exploring the relationship between social media use, eating behaviors, and depression in young women: a machine learning-based cross-sectional study. LID - 10.1186/s12889-026-28138-x [doi] LID - 2247 AB - BACKGROUND: The increasing prevalence of social media use among young adults has raised concerns regarding its potential associations with mental health and eating behaviors. The aim of this study was to investigate the associations between social media use, eating behaviors, and depressive symptoms among young women and to evaluate the performance of machine learning algorithms in modeling these cross-sectional associations compared with conventional regression approaches. METHODS: A cross-sectional study was conducted among young women aged 18-34 years (n = 4,692) using a multi-site, face-to-face convenience sampling strategy. The survey collected data on BMI, patterns of social media use, the Beck Depression Inventory (BDI), and the Scale of Effects of Social Media on Eating Behavior (SESMEB). In addition to standard statistical analyses, various ML models, including Random Forest and Extreme Gradient Boosting (XGBoost), were applied to model SESMEB and BDI scores. Model performance was evaluated using internal validation procedures, including a train-test split and cross-validation, and assessed using root mean square error (RMSE) and mean absolute error (MAE). RESULTS: The mean age of participants was 23.8 years, and the mean BMI was 22.3 kg/m(2). Significant differences in BMI, SESMEB, and BDI scores were observed across social media platform use groups. Users of Facebook, TikTok, and Snapchat reported significantly lower SESMEB scores (p < 0.001). ML models identified BMI, snack intake, and social media use as influential variables associated with SESMEB and BDI scores. Random Forest showed the best modeling performance in the test set for both SESMEB and BDI scores, with XGBoost performing comparably. CONCLUSIONS: Social media use was associated with eating-related behaviors and depressive symptoms in young women. Within the study sample, ML models demonstrated modest modeling performance for SESMEB and BDI scores and may provide a complementary framework for examining complex associations among behavioral and psychological variables. However, these findings were based on internal validation only and require confirmation in independent external samples. Further research is warranted to clarify the direction of these associations, explore platform-specific differences, and evaluate the external validity of these models. CI - (c) 2026. The Author(s). FAU - Altan, Murat AU - Altan M AUID- ORCID: 0000-0002-9561-4755 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Firat University, Elazig, Turkiye. FAU - Kocaman, Semsi Gul Yilmaz AU - Kocaman SGY AUID- ORCID: 0000-0002-2825-7401 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Karamanoglu Mehmetbey University, Karaman, Turkiye. semsigul10@gmail.com. FAU - Ulger, Taha Gokmen AU - Ulger TG AUID- ORCID: 0000-0002-7751-9789 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Bolu Abant Izzet Baysal University, Bolu, Turkiye. FAU - Onal, Seda AU - Onal S AUID- ORCID: 0000-0002-8074-5584 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Firat University, Elazig, Turkiye. FAU - Yildirim, Hasan AU - Yildirim H AUID- ORCID: 0000-0003-4582-9018 AD - Department of Data Science and Analytics, Kamil Ozdag Faculty of Science, Karamanoglu Mehmetbey University, Karaman, Turkiye. LA - eng PT - Journal Article DEP - 20260613 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - *Social Media/statistics & numerical data MH - Young Adult MH - Adult MH - *Depression/epidemiology MH - Adolescent MH - *Feeding Behavior/psychology MH - *Machine Learning MH - Predictive Learning Models MH - Digital Media MH - Media Exposure PMC - PMC13420861 OTO - NOTNLM OT - Artificial intelligence OT - Beck Depression Inventory OT - Body mass index OT - Eating behavior OT - Machine learning OT - Social media COIS- Declarations. Ethics approval and consent to participate: All procedures involving human participants were conducted in accordance with the principles of the Declaration of Helsinki. To protect participant privacy, all names and identifying information were anonymised. Participation was voluntary, and written informed consent was obtained from all participants prior to data collection. No financial compensation was provided for participation. Ethical approval for the study was granted by the Scientific Research and Publication Ethics Committee of Social and Human Sciences, Karamanoglu Mehmetbey University (Decision No: 02-2024/38; approval date: 23/01/2024). The official ethics approval document has been provided as supplementary material for editorial verification (Additional File 1). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/15 11:31 MHDA- 2026/07/31 06:37 PMCR- 2026/06/13 CRDT- 2026/06/13 23:35 PHST- 2026/04/05 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/07/31 06:37 [medline] PHST- 2026/06/15 11:31 [pubmed] PHST- 2026/06/13 23:35 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - 10.1186/s12889-026-28138-x [pii] AID - 28138 [pii] AID - 10.1186/s12889-026-28138-x [doi] PST - epublish SO - BMC Public Health. 2026 Jun 13;26(1):2247. doi: 10.1186/s12889-026-28138-x. PMID- 42288643 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20261023 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jun 13 TI - Micronutrient intake and food insecurity among mothers of infants with orofacial clefts: a cross-sectional study in Iran. LID - 10.1038/s41598-026-57977-2 [doi] LID - 27066 AB - Cleft lip with or without cleft palate is a common congenital craniofacial anomaly influenced by genetic and environmental factors. This cross-sectional study investigated maternal micronutrient intake and household food insecurity among Iranian mothers of infants with orofacial clefts. Mothers of infants aged 0-12 months with cleft lip (CL), cleft palate (CP), or both were recruited from a referral hospital in Tehran (2019-2020). Dietary intake was assessed using a validated food frequency questionnaire, and food security was evaluated with a standardized instrument. Multinomial logistic regression was performed to examine associations. High prevalences of inadequate intake were observed for iron (91.0%), vitamin D (73.6%), vitamin A (70.6%), folate (60.2%), calcium (56.7%), and vitamin B6 (50.7%). Vitamin B12 inadequacy differed significantly across cleft types (p = 0.023), with higher prevalence in CP (35.8%) and CL/P (38.6%) compared with CL (19.2%). Food insecurity also differed significantly by cleft type (p = 0.024), with hunger reported in 42.9% of the CL/P, 24.5% of the CP, and 20.5% of the CL groups. In multinomial logistic regression (reference: CL), food insecurity without hunger was associated with lower odds of CL/P in the crude model (OR = 0.30, 95% CI: 0.14-0.65), although this association was attenuated after adjustment. However, a significant trend between increasing food insecurity and cleft severity persisted across all models (P-trend = 0.028). These findings highlight the importance of maternal nutrition and food security in preventive strategies. CI - (c) 2026. The Author(s). FAU - Kalantar-Hormozi, Abdoljalil AU - Kalantar-Hormozi A AD - Research and Development Center, 15 Khordad Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Hojaji, Elham AU - Hojaji E AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. elhamhojaji@gmail.com. FAU - Avani, Anita AU - Avani A AD - Research and Development Center, 15 Khordad Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. anita.41724@gmail.com. FAU - Alijani, Sepideh AU - Alijani S AD - Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. FAU - Abaj, Faezeh AU - Abaj F AD - Department of Nutrition, Dietetics and Food, Faculty of Medicine, Nursing and Health Sciences, Monash University, Notting Hill, Australia. AD - Victorian Heart Institute, Victoria Heart Hospital, Clayton, VIC, Australia. FAU - Ebrahimian, Setayesh AU - Ebrahimian S AD - Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. AD - Student research committee, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260613 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Micronutrients) SB - IM MH - Humans MH - *Cleft Palate/epidemiology MH - *Cleft Lip/epidemiology MH - Iran/epidemiology MH - Cross-Sectional Studies MH - Female MH - *Food Insecurity MH - *Micronutrients MH - *Mothers MH - Infant MH - Adult MH - Infant, Newborn PMC - PMC13522343 OTO - NOTNLM OT - Cleft lip OT - Cleft palate OT - Dietary intake OT - Food insecurity OT - Orofacial clefts COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/06/15 11:34 MHDA- 2026/08/28 11:46 PMCR- 2026/06/13 CRDT- 2026/06/13 23:19 PHST- 2026/03/30 00:00 [received] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/08/28 11:46 [medline] PHST- 2026/06/15 11:34 [pubmed] PHST- 2026/06/13 23:19 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - 10.1038/s41598-026-57977-2 [pii] AID - 57977 [pii] AID - 10.1038/s41598-026-57977-2 [doi] PST - epublish SO - Sci Rep. 2026 Jun 13;16(1):27066. doi: 10.1038/s41598-026-57977-2. PMID- 42287140 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 1748-2631 (Electronic) IS - 1748-2623 (Print) IS - 1748-2623 (Linking) VI - 21 IP - 1 DP - 2026 Dec 31 TI - Physical activity, sleep, dietary habits, and screen time in Bogota's children post-pandemic lockdown: a mixed-methods study. PG - 2683936 LID - 10.1080/17482631.2026.2683936 [doi] LID - 2683936 AB - PURPOSE: This study explored how Bogota's children reconfigured their post-lockdown routines as part of their lived experience after returning to in-person activities. METHODS: A mixed-methods design was applied to capture behavioral patterns and their meanings. Quantitatively, 217 children aged 8-12 years attending pediatric clinics (Oct 2022-Sep 2023) completed validated questionnaires assessing physical activity, sleep, diet, and screen exposure. Qualitatively, semi-structured interviews were conducted with 15 children selected through purposive sampling to deepen insight into their daily routines and perceptions. Quantitative data were analyzed descriptively and by sex, while thematic analysis of interviews provided contextual interpretation. Integration occurred through a narrative weaving approach. RESULTS: Quantitative findings indicated moderate physical activity (66% met >/= 3 days/week), widespread sleep disturbances (49.7%), recreational screen use (median= 6 hours/day), and poor dietary intake (>90% consumed fewer than two vegetable servings daily). Narratives revealed that play was often replaced by structured adult-imposed activities, screen time served as both emotional refuge and behavioral reward, and sleep was self-managed through distractions such as eating or watching TV. Children viewed these habits as normal despite feelings of fatigue, frustration, and a longing for autonomy. CONCLUSION: Children's post-lockdown routines reflect adaptation rather than behavioral lapses, requiring interventions focus on emotional regulation, time balance, quality rest, and active play (not merely a return to pre-pandemic norms). FAU - Castrellon-Vergara, Shirley AU - Castrellon-Vergara S AUID- ORCID: 0009-0002-2359-9282 AD - Programa de Especializacion en Pediatria - Facultad de Medicina, Fundacion Universitaria Sanitas, Bogota D.C., Colombia. FAU - Rueda-Alfonso, Blanca Nathalia AU - Rueda-Alfonso BN AUID- ORCID: 0000-0003-1976-5495 AD - Programa de Especializacion en Pediatria - Facultad de Medicina, Fundacion Universitaria Sanitas, Bogota D.C., Colombia. FAU - Palacios-Ariza, Maria Alejandra AU - Palacios-Ariza MA AUID- ORCID: 0000-0002-9795-0285 AD - Unidad de Investigacion, Fundacion Universitaria Sanitas, Bogota D.C., Colombia. FAU - Guevara-Santamaria, Fabian Ricardo AU - Guevara-Santamaria FR AUID- ORCID: 0000-0003-0993-745X AD - Versania Primera Infancia, Grupo Keralty, Bogota, D.C., Colombia. LA - eng PT - Journal Article DEP - 20260613 PL - United States TA - Int J Qual Stud Health Well-being JT - International journal of qualitative studies on health and well-being JID - 101256506 SB - IM MH - Humans MH - Child MH - Female MH - *Screen Time MH - Male MH - *Sleep MH - *COVID-19/epidemiology MH - *Exercise MH - *Feeding Behavior MH - Colombia/epidemiology MH - *Diet MH - Surveys and Questionnaires MH - SARS-CoV-2 MH - *Quarantine/psychology MH - Sleep Duration MH - Qualitative Research PMC - PMC13267027 OTO - NOTNLM OT - COVID-19 OT - Child health OT - dietary habits OT - lifestyle OT - physical activity OT - screen time OT - sleep COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/15 11:31 MHDA- 2026/06/15 11:32 PMCR- 2026/06/13 CRDT- 2026/06/13 07:03 PHST- 2026/06/15 11:32 [medline] PHST- 2026/06/15 11:31 [pubmed] PHST- 2026/06/13 07:03 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - 2683936 [pii] AID - 10.1080/17482631.2026.2683936 [doi] PST - ppublish SO - Int J Qual Stud Health Well-being. 2026 Dec 31;21(1):2683936. doi: 10.1080/17482631.2026.2683936. Epub 2026 Jun 13. PMID- 42286440 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260925 IS - 2719-535X (Electronic) IS - 2719-6488 (Print) IS - 1428-345X (Linking) VI - 30 IP - 1 DP - 2026 Jan 1 TI - Comparative Performance of Machine Learning Models Using Food Intake Frequency Versus Vegetable Intake Data to Predict Problematic Mealtime Behaviour in Japanese Preschool Children. PG - 106-115 LID - 10.34763/jmotherandchild.20263001.d-25-00036 [doi] AB - BACKGROUND: Selective eating often leads to nutritional imbalance and mealtime stress, making early identification essential. OBJECTIVE: This study aimed to compare the predictive performance of machine learning (ML) models using two types of input data-namely, vegetable intake and food frequency questionnaire (FFQ) responses-to identify children with selective eating behaviour (cutoff score >/=1.59). MATERIAL AND METHODS: We analysed a cross-sectional dataset of 283 children aged 3-6 years using up to 8 predictors selected from 15 food-frequency items or 15 designated vegetables, along with age and sex. Selective eating behaviour was defined as a selective eating score of >/= 1.59. Eleven ML algorithms were trained and evaluated, resulting in 11,253 feature-model combinations. Model performance was assessed using 5-fold cross-validation based on accuracy, precision, recall, F1 score, and ROC-AUC. Permutation importance analysis was conducted to identify key predictive features. RESULTS: Among the 11 ML algorithms tested, vegetable intake-based L1 logistic regression showed the best performance (ROC-AUC = 0.717, accuracy = 0.647, precision = 0.722, recall = 0.659, F1 = 0.808). Permutation importance further identified tomato, green onion, and taro as key contributors in the vegetable intake-based L1 logistic regression model. In contrast, the FFQ-based Naive Bayes model showed relatively good discrimination (ROC-AUC = 0.619) despite moderate recall. CONCLUSION: Vegetable intake-based ML models were more effective than those using FFQ data in identifying children with selective eating behaviour. Detailed dietary assessment aids early detection. CI - (c) 2026 Naoki Sakane et al., published by Institute of Mother and Child. FAU - Sakane, Naoki AU - Sakane N AUID- ORCID: 0000-0002-2625-571X AD - Division of Preventive Medicine, Clinical Research Institute, National Hospital Organisation NHO Kyoto Medical Centre, Kyoto, Japan. FAU - Kawaguchi, Yaeko AU - Kawaguchi Y AD - Division of Preventive Medicine, Clinical Research Institute, National Hospital Organisation NHO Kyoto Medical Centre, Kyoto, Japan. FAU - Somei, Junichiro AU - Somei J AUID- ORCID: 0009-0007-0804-0831 AD - Division of Preventive Medicine, Clinical Research Institute, National Hospital Organisation NHO Kyoto Medical Centre, Kyoto, Japan. FAU - Suganuma, Akiko AU - Suganuma A AUID- ORCID: 0000-0002-2005-5151 AD - Division of Preventive Medicine, Clinical Research Institute, National Hospital Organisation NHO Kyoto Medical Centre, Kyoto, Japan. FAU - Domichi, Masayuki AU - Domichi M AUID- ORCID: 0000-0002-6157-8151 AD - Division of Preventive Medicine, Clinical Research Institute, National Hospital Organisation NHO Kyoto Medical Centre, Kyoto, Japan. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260608 PL - Poland TA - J Mother Child JT - Journal of mother and child JID - 101771247 RN - Japanese people SB - IM MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Male MH - Classification Algorithms MH - Cross-Sectional Studies MH - East Asian People/psychology/statistics & numerical data MH - *Feeding Behavior/psychology MH - Japan MH - *Machine Learning MH - *Meals/psychology MH - Predictive Learning Models MH - Surveys and Questionnaires/statistics & numerical data MH - *Vegetables MH - Prediction Algorithms PMC - PMC13263313 OTO - NOTNLM OT - food OT - machine learning OT - machine performance OT - mealtime behaviour OT - preschool children OT - vegetable COIS- Conflicts of interest The authors declare that there are no conflicts of interest. EDAT- 2026/06/13 00:40 MHDA- 2026/06/13 06:38 PMCR- 2026/06/08 CRDT- 2026/06/12 23:53 PHST- 2025/09/10 00:00 [received] PHST- 2025/12/05 00:00 [accepted] PHST- 2026/06/13 06:38 [medline] PHST- 2026/06/13 00:40 [pubmed] PHST- 2026/06/12 23:53 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - jmotherandchild.20263001.d-25-00036 [pii] AID - 10.34763/jmotherandchild.20263001.d-25-00036 [doi] PST - epublish SO - J Mother Child. 2026 Jun 8;30(1):106-115. doi: 10.34763/jmotherandchild.20263001.d-25-00036. eCollection 2026 Jan 1. PMID- 42286347 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20260821 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Jun 12 TI - Development and initial validation of the Mindful Eating Behaviour Scale for children and parents. LID - 10.1007/s40519-026-01881-1 [doi] LID - 75 AB - PURPOSE: This research aimed to address existing methodological limitations in research on mindful eating behaviours in children, to enhance future research in this area. This manuscript presents the development and the assessment of the validity and reliability of a Mindful Eating Behaviour Scale for children and parents across five studies. METHODS: Study 1 assessed the scale's content validity using ratings from experts in the field. Study 2 evaluated the internal consistency of the scales. Study 3 explored temporal stability using a test-retest design with a 2-week interval. Studies 4 and 5 examined the criterion-related validity of the scales. RESULTS: Study 1 demonstrated that the items reflected the definition of mindful eating behaviour and were suitable for children. Study 2 showed that the scale and the subscales, "sensory attention" and "non-judgemental awareness" demonstrated good internal consistency. Using exploratory factor analysis, the scale supported the presence of two factors, "sensory attention" and "non-judgemental awareness". Study 3 showed that the scale was a reliable measure over time. Studies 4 and 5 showed that the scales are suitable measures for mindful eating behaviour. The scales demonstrated correlations between mindfulness and other eating behaviours, but further research is required, as only limited associations were observed. CONCLUSIONS: The current research presents new psychometric scales for mindful eating in children. The studies show that the scale is valid and reliable. LEVEL OF EVIDENCE: No level of evidence: basic science. CI - (c) 2026. The Author(s). FAU - Dunsmore, Natasha AU - Dunsmore N AD - Department of Psychology, School of Health and Life Sciences, Birmingham City University, The Curzon Building, 4 Cardigan St, Birmingham, B4 7BD, UK. natasha.dunsmore@mail.bcu.ac.uk. FAU - Hussain, Misba AU - Hussain M AD - Department of Psychology, School of Health and Life Sciences, Birmingham City University, The Curzon Building, 4 Cardigan St, Birmingham, B4 7BD, UK. FAU - Giannou, Kyriaki AU - Giannou K AD - Department of Psychology, Faculty of Health and Life Sciences, De Montfort University, Leicester, UK. FAU - Mantzios, Michail AU - Mantzios M AD - Department of Psychology, School of Health and Life Sciences, Birmingham City University, The Curzon Building, 4 Cardigan St, Birmingham, B4 7BD, UK. LA - eng PT - Journal Article PT - Validation Study DEP - 20260612 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - *Feeding Behavior/psychology MH - *Mindfulness MH - Child MH - Reproducibility of Results MH - Psychometrics MH - *Parents/psychology MH - Female MH - Male MH - Surveys and Questionnaires MH - *Child Behavior/psychology PMC - PMC13486019 OTO - NOTNLM OT - Children OT - Children's eating behaviours OT - Eating behaviours OT - Mindful Eating Behaviour Scale OT - Mindful eating OT - Mindful eating behaviour COIS- Declarations. Ethical approval: Ethical approval was obtained by the host University's Ethical Committee corresponding ethical guidelines. Application approval number: Dunsmore/#13801/sub3/R(B)/2024/Dec/BLSS FAEC. Participants were presented with information sheets and consent forms, following specific instructions set in the guidelines of the British Psychological Society (BPS), where a designated consent page used checkboxes to allow participants to indicate that they have read and understood each statement and key aspects of the consent information before proceeding with the study. The BPS ethical guidelines were followed when collecting the research and specified the retention of data for 10 years in a secure institutional server, to which participants also provided consent. Consent to participate: Informed consent was obtained from all individual participants included in the study. Consent for publication: Informed consent was obtained from all individual participants to publish the findings of this research. Competing interests: The authors declare no competing interests. EDAT- 2026/06/13 00:39 MHDA- 2026/08/19 14:49 PMCR- 2026/06/12 CRDT- 2026/06/12 23:26 PHST- 2025/12/12 00:00 [received] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/08/19 14:49 [medline] PHST- 2026/06/13 00:39 [pubmed] PHST- 2026/06/12 23:26 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - 10.1007/s40519-026-01881-1 [pii] AID - 1881 [pii] AID - 10.1007/s40519-026-01881-1 [doi] PST - epublish SO - Eat Weight Disord. 2026 Jun 12;31(1):75. doi: 10.1007/s40519-026-01881-1. PMID- 42286317 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260831 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Jun 13 TI - Development and validation of the Japanese version of Sociocultural Attitudes Towards Appearance Questionnaire-4-Revised (SATAQ-4R) among Japanese adolescents. LID - 10.1007/s40519-026-01877-x [doi] LID - 76 AB - PURPOSE: Internalization of appearance ideals and sociocultural pressures contribute to body dissatisfaction and eating disorders. Japanese adolescents report high levels of body dissatisfaction despite relatively low body mass index compared to peers in other countries, highlighting potential cultural influences. However, the Sociocultural Attitudes Towards Appearance Questionnaire-4-Revised (SATAQ-4R) has not been validated in Japan. This study aimed to develop a Japanese version of the SATAQ-4R and examine its psychometric properties among Japanese adolescents. METHODS: A nationwide population-based study was conducted in 2023 among 1,368 adolescents aged 11-17 years (girls: n = 694; boys: n = 674). Participants completed self-reported questionnaires. The factor structure of the SATAQ-4R was evaluated using exploratory and confirmatory factor analyses (EFA and CFA), internal consistency was assessed using Cronbach's alpha, and convergent validity was examined using eating-related measures. RESULTS: EFA suggested a five-factor 23-item structure for girls and a seven-factor 23-item structure for boys. CFA showed suboptimal fit for the female model and comparatively better fit for the male model. Most subscales showed acceptable internal consistency, although one female pressure-related subscale showed inadequate reliability. Correlations with external measures provided partial evidence of convergent validity, with associations varying by sex and subscale. CONCLUSION: These findings provide preliminary evidence for psychometric properties of the Japanese SATAQ-4R. However, suboptimal female model fit, inadequate reliability of one female subscale, and mixed convergent validity evidence indicate that the resulting Japanese models should be used with caution. LEVEL OF EVIDENCE: Level III, cross-sectional observational study. CI - (c) 2026. The Author(s). FAU - Saito, Takumi AU - Saito T AD - Center for Postgraduate Education and Training, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan. AD - Department of Life Course Epidemiology, Integrated Center for Women's Health, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan. FAU - Ishitsuka, Kazue AU - Ishitsuka K AD - Department of Life Course Epidemiology, Integrated Center for Women's Health, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan. ishitsuka-k@ncchd.go.jp. FAU - Piedvache, Aurelie AU - Piedvache A AD - Department of Social Medicine, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan. FAU - Yamaguchi, Satoshi AU - Yamaguchi S AD - Unit for Mental Health Promotion, Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan. FAU - Yamasaki, Syudo AU - Yamasaki S AD - Unit for Mental Health Promotion, Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan. FAU - Usami, Satoshi AU - Usami S AD - Graduate School of Education, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. FAU - Ishiguro, Akira AU - Ishiguro A AD - Department of Pediatrics, National Disaster Medical Center, 3256 Midoricho, Tachikawa, Tokyo, 190-0014, Japan. FAU - Morisaki, Naho AU - Morisaki N AD - Department of Social Medicine, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan. LA - eng GR - 23K12759/Japan Society for the Promotion of Science/ GR - 22H03362/Japan Society for the Promotion of Science/ GR - JPCA24DA1234/Children and Families Agency Program/ GR - 2023B-13/The Grant of National Center for Child Health and Development/ GR - 2025A-3/The Grant of National Center for Child Health and Development/ GR - JPJSJRP20211709/JRP-LEAD with UKRI/ GR - 23FB1003/Health Labour Sciences Research Grants/ PT - Journal Article PT - Validation Study DEP - 20260613 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 RN - Japanese people SB - IM MH - Humans MH - Male MH - Adolescent MH - Female MH - Japan MH - Psychometrics MH - Child MH - *Body Image/psychology MH - Reproducibility of Results MH - Surveys and Questionnaires MH - *Attitude MH - Factor Analysis, Statistical MH - Body Satisfaction MH - *Body Dissatisfaction/psychology MH - East Asian People PMC - PMC13518460 OTO - NOTNLM OT - Adolescents OT - Body image OT - SATAQ-4R OT - Social media OT - Thin internalization OT - Validation COIS- Declarations. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki and the Ethical Guidelines for Clinical/Epidemiological Studies of the Japanese Ministry of Health, Labour, and Welfare. Ethical approval was obtained from the Ethics Committee of the National Center for Child Health, Japan (No. 2021-133). Consent to participate: Written informed consent was obtained from the participants and their guardians. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/13 00:40 MHDA- 2026/08/27 05:35 PMCR- 2026/06/13 CRDT- 2026/06/12 23:25 PHST- 2026/03/13 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/08/27 05:35 [medline] PHST- 2026/06/13 00:40 [pubmed] PHST- 2026/06/12 23:25 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - 10.1007/s40519-026-01877-x [pii] AID - 1877 [pii] AID - 10.1007/s40519-026-01877-x [doi] PST - epublish SO - Eat Weight Disord. 2026 Jun 13;31(1):76. doi: 10.1007/s40519-026-01877-x. PMID- 42285572 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 6 DP - 2026 Jun 12 TI - Association of 24-hour movement guideline adherence with mental health symptoms among Colombian university students: a cross-sectional study. PG - e118611 LID - 10.1136/bmjopen-2026-118611 [doi] LID - e118611 AB - OBJECTIVE: This study aimed to determine the associations between adherence to the 24-hour movement guidelines and symptoms of anxiety and depression among Colombian university students. STUDY DESIGN: Cross-sectional study. PARTICIPANTS: 1125 individuals (mean age 20.2+/-2.5 years; 56.7% female). SETTING: Students sampled from a single public university. PRIMARY AND SECONDARY OUTCOME MEASURES: Participants completed validated self-report instruments: the International Physical Activity Questionnaire-Short Form to assess physical activity (PA), sedentary behaviour (SB) and the Pittsburgh Sleep Quality Index to assess sleep duration. Symptoms of depression and anxiety were measured using the Hospital Anxiety and Depression Scale, with a score of >/=11 used to classify elevated symptoms. Binary logistic regression models were used to estimate associations between adherence to the 24-hour movement guidelines (meeting all three, two, one or none) and mental health outcomes, adjusting for potential confounders. RESULTS: Only 15.5% of students met all three components of the 24-hour movement guidelines. Meeting a greater number of components was significantly associated with lower odds of depressive and anxiety symptoms. In fully adjusted analyses, students who met all three guidelines were less likely to report anxiety symptoms (OR=0.26; 95%CI 0.13 to 0.54) and depressive symptoms (OR=0.42; 95%CI 0.22 to 0.79) compared with those who met none. Among individual behaviours, sufficient PA and adequate sleep were independently associated with lower odds of both outcomes, whereas high SB was associated with higher odds of elevated symptoms. CONCLUSIONS: In this cross-sectional study, adherence to a greater number of 24-hour movement guideline components was associated with lower levels of anxiety and depressive symptoms in a graded manner. However, the cross-sectional design precludes inference regarding directionality or causality, and bidirectional associations or residual confounding remain possible. Longitudinal and interventional studies are needed to determine whether integrated daily movement behaviours influence mental health outcomes in young adults, particularly in Latin American populations. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Romero-Martinez, Gonzalo AU - Romero-Martinez G AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Urriago-Fontal, Juan Carlos AU - Urriago-Fontal JC AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Quirama-Garcia, Hector Mario AU - Quirama-Garcia HM AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Ortiz-Lopez, Julian David AU - Ortiz-Lopez JD AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Arias-Alzate, Carolina AU - Arias-Alzate C AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Gutierrez-Quintero, Gustavo Adolfo AU - Gutierrez-Quintero GA AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Palma Pulido, Luis Hebert AU - Palma Pulido LH AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Calderon-Gonzalez, Juan Carlos AU - Calderon-Gonzalez JC AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Ramirez-Velez, Robinson AU - Ramirez-Velez R AUID- ORCID: 0000-0003-3075-6960 AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia robin640@hotmail.com robinson.ramirez@unavarra.es. AD - Navarrabiomed, Hospital Universitario de Navarra (HUN), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Universidad Publica de Navarra (UPNA), Pamplona, Spain. AD - CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain. LA - eng PT - Journal Article DEP - 20260612 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Colombia/epidemiology MH - Young Adult MH - *Students/psychology MH - *Depression/epidemiology/prevention & control MH - *Anxiety/epidemiology/prevention & control MH - Male MH - *Exercise/psychology MH - Universities MH - *Guideline Adherence MH - Sedentary Behavior MH - *Mental Health MH - Sleep Duration MH - Adult MH - Adolescent MH - Logistic Models MH - Surveys and Questionnaires MH - Self Report PMC - PMC13289006 OTO - NOTNLM OT - Anxiety disorders OT - Depression & mood disorders OT - Exercise OT - Health OT - SLEEP MEDICINE OT - Young Adult COIS- Competing interests: None declared. EDAT- 2026/06/13 00:38 MHDA- 2026/06/13 06:38 PMCR- 2026/06/12 CRDT- 2026/06/12 20:43 PHST- 2026/06/13 06:38 [medline] PHST- 2026/06/13 00:38 [pubmed] PHST- 2026/06/12 20:43 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - bmjopen-2026-118611 [pii] AID - 10.1136/bmjopen-2026-118611 [doi] PST - epublish SO - BMJ Open. 2026 Jun 12;16(6):e118611. doi: 10.1136/bmjopen-2026-118611. PMID- 42282294 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260612 LR - 20260813 IS - 0973-2063 (Print) IS - 0973-2063 (Electronic) IS - 0973-2063 (Linking) VI - 22 IP - 4 DP - 2026 TI - Weight-for-age and mid-upper arm circumference versus weight-for-length as severe acute malnutrition indicators: A validation study in under-6-month infants. PG - 2305-2309 LID - 10.6026/973206300222305 [doi] AB - Infants are more susceptible to malnutrition than older children. The prevalence of severe wasting among Indian infants under-6 months of age is 14.8% according to the National Family Health Survey-4. The myth of complete protection by exclusive breastfeeding is debated when the prevalence of severe acute malnutrition (SAM) sprang up as high as 23.8% in a cross sectional study from Central India among 600 infants. Area under the curve for MUAC <11 cm was 0.936 (95% confidence interval); its sensitivity and specificity were 69.23% and 73.09%, respectively; area under the curve for weight-for-age had higher sensitivity at (88.81%), but lower specificity (61.1%). The highlighted modifiable risk factors were low birth weight and adverse feeding practices. Combined MUAC and weight-for-length screening strategies should be used specifically in low-resource, community-based contexts for SAM in infants aged under six months. CI - (c) 2026 Biomedical Informatics. FAU - Pinky, Kumari AU - Pinky K AD - Department of Paediatrics, Government Medical College, Satna, Madhya Pradesh, India. FAU - Mahore, Rashmi Randa AU - Mahore RR AD - Department of Pediatrics, GMC Bhopal, Madhya Pradesh, India. FAU - Thakur, Shiva Saloni AU - Thakur SS AD - Department of Pediatrics, Civil hospital Amarwara, Chhindwara, Madhya Pradesh, India. FAU - Parmar, Sachin AU - Parmar S AD - Department of Community Medicine, V.K.S. Government Medical College, Neemuch, India. LA - eng PT - Journal Article DEP - 20260430 PL - Singapore TA - Bioinformation JT - Bioinformation JID - 101258255 PMC - PMC13252213 OTO - NOTNLM OT - Severe acute malnutrition (SAM) OT - infants under six months OT - mid-upper arm circumference (MUAC) EDAT- 2026/06/12 06:38 MHDA- 2026/06/12 06:39 PMCR- 2026/04/30 CRDT- 2026/06/12 05:02 PHST- 2026/04/01 00:00 [received] PHST- 2026/04/30 00:00 [revised] PHST- 2026/04/30 00:00 [accepted] PHST- 2026/06/12 06:39 [medline] PHST- 2026/06/12 06:38 [pubmed] PHST- 2026/06/12 05:02 [entrez] PHST- 2026/04/30 00:00 [pmc-release] AID - 973206300222305 [pii] AID - 10.6026/973206300222305 [doi] PST - epublish SO - Bioinformation. 2026 Apr 30;22(4):2305-2309. doi: 10.6026/973206300222305. eCollection 2026. PMID- 42281579 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260612 LR - 20260813 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 6 DP - 2026 Jun TI - Dietary Index for Gut Microbiota and the Odds of Metabolic Dysfunction-Associated Fatty Liver Disease in Overweight and Obese Children and Adolescents: A Cross-Sectional Study. PG - e72640 LID - 10.1002/hsr2.72640 [doi] LID - e72640 AB - BACKGROUND AND AIMS: Metabolic dysfunction-associated fatty liver disease (MAFLD) is increasingly prevalent among children and adolescents with overweight or obesity, posing a growing public health challenge. Emerging evidence highlights the gut microbiota as a critical mediator in MAFLD pathogenesis, yet few studies have explored dietary factors influencing this axis in pediatric populations. This cross-sectional study investigated the association between the Dietary Index for Gut Microbiota (DI-GM) and MAFLD. METHODS: A total of 505 Iranian youths aged 7-18 years enrolled in a national obesity registry. Dietary intake was assessed via a validated 147-item Food Frequency Questionnaire. MAFLD was diagnosed according to international expert consensus, requiring ultrasound‑confirmed hepatic steatosis in the presence of overweight/obesity or other metabolic abnormalities. RESULTS: Multivariable logistic regression models revealed that higher DI-GM scores were significantly associated with lower odds of MAFLD (OR per unit increase: 0.80, 95% CI: 0.71-0.91; p < 0.001). Participants in the highest DI-GM quartile had markedly reduced risk compared to the lowest quartile (OR: 0.42, 95% CI: 0.22-0.81). Notably, the inverse association was significant only among post-pubertal participants. Mediation analysis indicated that liver enzymes-alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), and aspartate aminotransferase (AST)-partially explained this relationship, accounting for 20.0%, 19.2%, and 6.7% of the association, respectively. CONCLUSION: These findings underscore the potential of microbiota-oriented dietary strategies to mitigate MAFLD risk in pediatric populations with obesity. CI - (c) 2026 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Kamrani, Farzam AU - Kamrani F AUID- ORCID: 0009-0001-2460-4218 AD - Department of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran. FAU - Nikparast, Ali AU - Nikparast A AUID- ORCID: 0000-0003-2686-2584 AD - Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition & Food Technology Research Institute Shahid Beheshti University of Medical Sciences Tehran Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology Shahid Beheshti University of Medical Sciences Tehran Iran. FAU - Tabatabaeyan, Ali AU - Tabatabaeyan A AUID- ORCID: 0009-0005-9974-3537 AD - Department of Clinical Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Students' Research Committee Isfahan University of Medical Sciences Isfahan Iran. FAU - Etesami, Elahe AU - Etesami E AD - Department of Nutrition SR.C., Islamic Azad University Tehran Iran. FAU - Rohani, Pejman AU - Rohani P AD - Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Center of Excellence, Children's Medical Center Tehran University of Medical Sciences Tehran Iran. FAU - Asghari, Golaleh AU - Asghari G AUID- ORCID: 0000-0002-7925-5158 AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology Shahid Beheshti University of Medical Sciences Tehran Iran. LA - eng PT - Journal Article DEP - 20260610 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC13250465 OTO - NOTNLM OT - Dietary Index for Gut Microbiota OT - MAFLD OT - adolescent OT - children OT - metabolic dysfunction-associated fatty liver disease COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:39 MHDA- 2026/06/12 06:40 PMCR- 2026/06/10 CRDT- 2026/06/12 04:54 PHST- 2025/10/10 00:00 [received] PHST- 2026/03/30 00:00 [revised] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/06/12 06:40 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 04:54 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - HSR272640 [pii] AID - 10.1002/hsr2.72640 [doi] PST - epublish SO - Health Sci Rep. 2026 Jun 10;9(6):e72640. doi: 10.1002/hsr2.72640. eCollection 2026 Jun. PMID- 42281577 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260612 LR - 20260813 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 6 DP - 2026 Jun TI - Household Water and Sanitation Practices and Their Association With Diarrheal and Acute Respiratory Infections Among Children Under Five in Ghana: A Cross-Sectional Predictive Model and Spatial Analysis. PG - e72628 LID - 10.1002/hsr2.72628 [doi] LID - e72628 AB - BACKGROUND AND AIMS: Diarrhea and acute respiratory infections (ARI) remain leading causes of under-five morbidity in low- and middle-income countries. Although Ghana achieved improved drinking water and sanitation coverage, significant regional and socioeconomic inequities persist. This study examined the associations between household water, sanitation, and hygiene (WASH) practices and diarrhea, ARI, and their comorbidity among under-five children in Ghana. METHODS: A cross-sectional analysis of 6344 children aged 0-59 months from the 2022 Ghana Demographic and Health Survey was conducted. Survey-weighted descriptive statistics and multilevel logistic regression were applied. Predictive performance was assessed using fivefold cluster-preserving cross-validation, Brier scores, calibration slopes, calibration plots, and cross-validated area under the curve (AUC). Spatial patterns were described using choropleth maps, Global Moran's I, Getis-Ord Gi*, and Local Moran's I (LISA). Counterfactual WASH reductions were estimated with bootstrap confidence intervals (200 replicates). A complementary random-effects meta-analysis quantified between-region heterogeneity (I(2)). RESULTS: Two-week prevalence of diarrhea, ARI, and comorbidity was 14.4% (95% CI: 12.7%-16.3%), 5.6% (95% CI: 4.7%-6.6%), and 1.8% (95% CI: 1.3%-2.5%), respectively, with a pronounced north-south gradient. No WASH variable reached significance in adjusted multilevel models. Diarrhea was associated with child age 6-35 months, maternal secondary and higher education, and household wealth. ARI was associated with co-occurring diarrhea and stunting. Stunting was the sole significant predictor of comorbidity. Community-level factors explained 21%-35% of variance. Cross-validated AUC was 0.787 (diarrhea), 0.896 (ARI), and 0.577 (comorbidity); calibration slopes were 3.68-11.68 (all poor). Global Moran's I showed no significant spatial autocorrelation for all three outcomes. Improving cooking fuel universally was the only scenario associated with a statistically significant absolute reduction in diarrhea prevalence: 1.4% points (relative reduction 13.9%; 95% CI: 6.2%-21.6%). CONCLUSIONS: Household WASH infrastructure showed no significant adjusted association with childhood diarrhea, ARI, or comorbidity after controlling for socioeconomic and nutritional confounders. A pronounced north-south disease gradient calls for geographically targeted, multisectoral interventions. Predictive models demonstrated adequate discrimination but poor calibration, limiting their use to population-level risk stratification. CI - (c) 2026 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Salifu, Yula AU - Salifu Y AUID- ORCID: 0000-0003-1223-1765 AD - Department of Population, Family and Reproductive Health, School of Public Health University of Ghana Legon Ghana. FAU - Gyan, Paul AU - Gyan P AD - Health Facilities Regulatory Agency Ashanti Region Ghana. FAU - Lasong, Joseph AU - Lasong J AD - Department of Population and Reproductive Health University for Development Studies Tamale Ghana. FAU - Walana, Williams AU - Walana W AUID- ORCID: 0000-0002-2938-1332 AD - Department of Clinical Microbiology, School of Medicine University for Development Studies Tamale Ghana. LA - eng PT - Journal Article DEP - 20260609 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC13250393 OTO - NOTNLM OT - Ghana OT - WASH OT - acute respiratory infections OT - children under five OT - demographic and health survey OT - diarrhea OT - multilevel modeling OT - predictive modeling OT - spatial analysis COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:39 MHDA- 2026/06/12 06:40 PMCR- 2026/06/09 CRDT- 2026/06/12 04:54 PHST- 2025/10/24 00:00 [received] PHST- 2026/04/04 00:00 [revised] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/06/12 06:40 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 04:54 [entrez] PHST- 2026/06/09 00:00 [pmc-release] AID - HSR272628 [pii] AID - 10.1002/hsr2.72628 [doi] PST - epublish SO - Health Sci Rep. 2026 Jun 9;9(6):e72628. doi: 10.1002/hsr2.72628. eCollection 2026 Jun. PMID- 42280414 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 11 DP - 2026 May 30 TI - Cultural and Sex-Related Differences in Free-Word Associations with "Sweets": A Multinational Online Study. LID - 10.3390/nu18111771 [doi] LID - 1771 AB - Background: Free-word association (FWA) captures the most accessible lexical responses to a stimulus, providing a window into automatic cognitive representations of food categories that may differ across cultures and between sexes. Objectives: To examine whether the dominant cognitive associations evoked by the word "sweets" differ across three language groups (Hungarian, English, Spanish), whether they vary by sex, and whether they relate to body mass index (BMI) and self-reported eating disorder risk. Methods: A total of 1349 participants completed an online survey including a single FWA prompt. Responses were classified into 10 semantic categories and analyzed using chi-square tests. Effect sizes (Cramer's V) were reported for all tests. Height and weight were converted to uniform metric units, and BMI was calculated. Results: The association profile differed significantly across language groups (chi(2)[18] = 210.05, p < 0.001, V = 0.28). Chocolate dominated Hungarian responses, while Baked goods/Desserts and Sugar/Candy dominated English, and Positive emotion and Baked goods/Desserts predominated among Spanish speakers. Sex differences were significant overall (chi(2)[9] = 43.72, p < 0.001, V = 0.18). BMI distributions differed markedly across nations (chi(2)[6] = 157.17, p < 0.001, V = 0.26), and sweets categories were significantly associated with eating disorder risk (chi(2)[27] = 48.04, p = 0.008, V = 0.11); however, this result should be interpreted with caution given the extreme skew toward the lowest-risk category [84.2%], with Negative/Health associations overrepresented among higher-risk participants. Conclusions: Cultural context plays a significant role in shaping automatic cognitive associations with sweet foods. The exploratory association between sweets categories and self-reported eating disorder risk warrants further investigation using validated instruments before any substantive conclusions can be drawn. FAU - Avena, Nicole AU - Avena N AD - Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. AD - Health Psychology, Princeton University, Princeton, NJ 08544, USA. FAU - Kovacs, Reka Erika AU - Kovacs RE AUID- ORCID: 0009-0007-0243-6878 AD - Faculty of Health and Sport Sciences, Szechenyi Istvan University, 9026 Gyor, Hungary. FAU - Somogyi, Angela AU - Somogyi A AD - Faculty of Health and Sport Sciences, Szechenyi Istvan University, 9026 Gyor, Hungary. FAU - de la Vega, Ricardo AU - de la Vega R AUID- ORCID: 0000-0002-7395-3297 AD - Departamento de Educacion Fisica, Deporte y Motricidad Humana, Universidad Autonoma de Madrid, 28049 Madrid, Spain. FAU - Szabo, Attila AU - Szabo A AUID- ORCID: 0000-0003-2788-4304 AD - Faculty of Health and Sport Sciences, Szechenyi Istvan University, 9026 Gyor, Hungary. LA - eng PT - Journal Article DEP - 20260530 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Female MH - Body Mass Index MH - Sex Factors MH - Adult MH - Feeding and Eating Disorders/psychology MH - Young Adult MH - Language MH - *Food Preferences/psychology/ethnology MH - *Cross-Cultural Comparison MH - Adolescent MH - Surveys and Questionnaires MH - Cognition PMC - PMC13258868 OTO - NOTNLM OT - BMI OT - cross-cultural OT - eating behavior OT - eating disorders OT - free-word association OT - sex differences COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:38 MHDA- 2026/06/13 00:38 PMCR- 2026/05/30 CRDT- 2026/06/12 01:11 PHST- 2026/04/03 00:00 [received] PHST- 2026/05/27 00:00 [revised] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/06/13 00:38 [medline] PHST- 2026/06/12 06:38 [pubmed] PHST- 2026/06/12 01:11 [entrez] PHST- 2026/05/30 00:00 [pmc-release] AID - nu18111771 [pii] AID - nutrients-18-01771 [pii] AID - 10.3390/nu18111771 [doi] PST - epublish SO - Nutrients. 2026 May 30;18(11):1771. doi: 10.3390/nu18111771. PMID- 42280399 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 11 DP - 2026 May 29 TI - Ponderal Status, Eating and Lifestyle Habits in Rural School Children: A Pilot Survey of the SBAM-ONFOODS Cohort Study. LID - 10.3390/nu18111756 [doi] LID - 1756 AB - Background/Objectives: The rising prevalence of overweight and obesity reflects a trend towards worsening eating habits and reduced physical activity, with significant implications for public health and life expectancy. This pilot survey aimed to evaluate weight status, food habits and lifestyle in primary school children from under-researched rural areas of the Lazio region, Italy. Methods: A total of 182 children aged 6-10 years from the municipalities of Monte Romano and Tolfa were enrolled. Body Mass Index (BMI), calculated from measured weight and height, was classified by IOTF and WHO definitions. Food habits, socioeconomic factors and lifestyle were evaluated by a standard questionnaire, and adherence to the Mediterranean diet (MD) was assessed by the KIDMED test. Results: Data showed a high prevalence of overweight, including obesity (33.3%), based on IOTF criteria, with slightly higher rates in boys than girls (38.3% vs. 26.9%). According to the WHO definition, the rate of overweight/obesity was 39.5% with significant differences between males and females (46% vs. 30.8%). Only 19.9% of children had high adherence to MD (67.3% moderate, 12.9% low), and 29.5% of the sample did not eat breakfast every day. In addition, 25.4% met international physical activity recommendations, while around 40% exceeded the recommended screen time on weekend days, and 19.3% did not sleep the recommended hours. Conclusions: Preliminary data show high rates of excess weight, poor diet quality and unhealthy lifestyles. Extending the sampling to other municipalities in the study area will help validate these findings and provide deeper insights to inform targeted intervention strategies. FAU - Galfo, Myriam AU - Galfo M AUID- ORCID: 0000-0003-4037-2979 AD - Consiglio per la Ricerca in Agricoltura e l'Analisi dell'Economia Agraria (CREA), Centro di Ricerca Alimenti e Nutrizione (Council for Agricultural Research and Economics, Research Centre for Food and Nutrition), Via Ardeatina 546, 00178 Rome, Italy. FAU - D'Addezio, Laura AU - D'Addezio L AUID- ORCID: 0000-0003-3392-5539 AD - Consiglio per la Ricerca in Agricoltura e l'Analisi dell'Economia Agraria (CREA), Centro di Ricerca Alimenti e Nutrizione (Council for Agricultural Research and Economics, Research Centre for Food and Nutrition), Via Ardeatina 546, 00178 Rome, Italy. FAU - Roccaldo, Romana AU - Roccaldo R AUID- ORCID: 0000-0003-2976-3864 AD - Consiglio per la Ricerca in Agricoltura e l'Analisi dell'Economia Agraria (CREA), Centro di Ricerca Alimenti e Nutrizione (Council for Agricultural Research and Economics, Research Centre for Food and Nutrition), Via Ardeatina 546, 00178 Rome, Italy. FAU - Censi, Laura AU - Censi L AUID- ORCID: 0000-0002-8769-6914 AD - Consiglio per la Ricerca in Agricoltura e l'Analisi dell'Economia Agraria (CREA), Centro di Ricerca Alimenti e Nutrizione (Council for Agricultural Research and Economics, Research Centre for Food and Nutrition), Via Ardeatina 546, 00178 Rome, Italy. LA - eng GR - PE00000003/European Union/ PT - Journal Article DEP - 20260529 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - Pilot Projects MH - *Feeding Behavior MH - *Life Style MH - *Rural Population/statistics & numerical data MH - Italy/epidemiology MH - Body Mass Index MH - Prevalence MH - Diet, Mediterranean MH - Overweight/epidemiology MH - *Pediatric Obesity/epidemiology MH - Cohort Studies MH - Exercise MH - Socioeconomic Factors MH - Surveys and Questionnaires PMC - PMC13258498 OTO - NOTNLM OT - children OT - food habits OT - lifestyle OT - ponderal status COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:39 MHDA- 2026/06/15 11:31 PMCR- 2026/05/29 CRDT- 2026/06/12 01:11 PHST- 2026/04/21 00:00 [received] PHST- 2026/05/22 00:00 [revised] PHST- 2026/05/26 00:00 [accepted] PHST- 2026/06/15 11:31 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 01:11 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - nu18111756 [pii] AID - nutrients-18-01756 [pii] AID - 10.3390/nu18111756 [doi] PST - epublish SO - Nutrients. 2026 May 29;18(11):1756. doi: 10.3390/nu18111756. PMID- 42280396 OWN - NLM STAT- MEDLINE DCOM- 20260614 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 11 DP - 2026 May 29 TI - Effect of a Theory-Informed, Six-Week Gamified Educational Intervention on Hydration Knowledge, Behavior, and Status in School Children: A Randomized Controlled Trial. LID - 10.3390/nu18111753 [doi] LID - 1753 AB - Aim: This study assessed the effects of a six-week educational intervention using an adapted "Snakes and Ladders" board game on hydration knowledge, behavior, and status among Tunisian elementary school children during physical education (PE) lessons. Method: A randomized controlled trial involving 207 children was conducted, with participants assigned to either the educational group (EG, n = 99) or the control group (CG, n = 108). The EG participated in six weekly 30-min board game sessions, while the CG continued regular activities. Knowledge of hydration was assessed using a validated questionnaire. Hydration status was monitored indirectly by the percentage change in body mass from pre- to post-PE session. Perceived thirst was evaluated using a 9-point scale, and hydration behavior was evaluated based on water consumption during PE lessons. Results: Following the intervention, the EG demonstrated a significant improvement in overall hydration knowledge (DeltaMean = +0.30 +/- 0.11 vs. -0.05 +/- 0.08 in CG; p < 0.001). Water intake during PE sessions increased progressively from week 2 (83.6 +/- 127.2 mL) to week 6 (311.2 +/- 204 mL) in the EG, whereas it remained unchanged in the CG (p < 0.001). Body mass loss after PE sessions decreased significantly in the EG (-0.03 kg) compared with the CG (-0.16 kg; p < 0.001), and perceived thirst before and after PE sessions was markedly lower (Cohen's d = 0.75-1.32). Conclusions. The six-week board-game intervention appeared effective in increasing hydration knowledge, promoting healthier drinking behaviors during PE, and improving indirect indicators of hydration status. These findings provide preliminary evidence for the feasibility and educational value of a gamified, low-cost approach to hydration promotion in schools. Further research should examine long-term retention, include objective hydration biomarkers, and evaluate applicability across diverse school settings and environmental conditions. FAU - Kacem, Sana AU - Kacem S AUID- ORCID: 0009-0008-9542-3511 AD - High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax 3000, Tunisia. AD - Research Laboratory, Education, Motricity, Sport and Health (EM2S), LR15JS01, High Institute of Sport and Physical Education, University of Sfax, Sfax 3000, Tunisia. FAU - Trabelsi, Khaled AU - Trabelsi K AUID- ORCID: 0000-0003-2623-9557 AD - High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax 3000, Tunisia. AD - Research Laboratory, Education, Motricity, Sport and Health (EM2S), LR15JS01, High Institute of Sport and Physical Education, University of Sfax, Sfax 3000, Tunisia. AD - Department of Movement Sciences and Sports Training, School of Sport Science, The University of Jordan, Amman 11942, Jordan. FAU - Ceylan, Halil Ibrahim AU - Ceylan HI AUID- ORCID: 0009-0005-2214-4667 AD - Department of Physical Education of Sports Teaching, Faculty of Sports Sciences, Ataturk University, 25240 Erzurum, Turkiye. FAU - Khacharem, Aimen AU - Khacharem A AUID- ORCID: 0000-0001-9088-3967 AD - College of Sport Sciences, Qatar University, Doha 2713, Qatar. FAU - Ammar, Achraf AU - Ammar A AUID- ORCID: 0000-0003-0347-8053 AD - High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax 3000, Tunisia. AD - Department of Training and Movement Science, Institute of Sport Science, Johannes Gutenberg-University Mainz, 55122 Mainz, Germany. AD - Research Laboratory, Molecular Bases of Human Pathology, LR19ES13, Faculty of Medicine, University of Sfax, Sfax 3000, Tunisia. AD - Department of Nutrition and Food Technology, School of Agriculture, The University of Jordan, Amman 11942, Jordan. FAU - Clark, Cain C T AU - Clark CCT AUID- ORCID: 0000-0002-6610-4617 AD - School of Life and Health Sciences, Birmingham City University, Birmingham B15 3TN, UK. FAU - Abed, Kais El AU - Abed KE AUID- ORCID: 0000-0001-9085-6379 AD - Research Laboratory, Education, Motricity, Sport and Health (EM2S), LR15JS01, High Institute of Sport and Physical Education, University of Sfax, Sfax 3000, Tunisia. FAU - Jahrami, Haitham AU - Jahrami H AUID- ORCID: 0000-0001-8990-1320 AD - Department of Psychiatry, College of Medicine and Medical Sciences, Arabian Gulf University, Manama 329, Bahrain. FAU - Muntean, Raul Ioan AU - Muntean RI AUID- ORCID: 0000-0003-4615-6687 AD - Department of Physical Education and Sport, Faculty of Law and Social Sciences, University "1 Decembrie 1918" of Alba Iulia, 510009 Alba Iulia, Romania. FAU - Dergaa, Ismail AU - Dergaa I AUID- ORCID: 0000-0001-8091-1856 AD - High Institute of Sport and Physical Education of Kef, University of Jendouba, Jendouba 7100, Tunisia. AD - Physical Activity Research Unit, Sport and Health (UR18JS01), National Observatory of Sports, Tunis 1003, Tunisia. FAU - Bragazzi, Nicola Luigi AU - Bragazzi NL AD - Department of Clinical Pharmacy, Saarland University, 66123 Saarbrucken, Germany. FAU - Aziz, Abdul Rashid AU - Aziz AR AUID- ORCID: 0000-0002-7727-7484 AD - Sport Science and Sports Medicine, Singapore Sport Institute, Singapore 397630, Singapore. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260529 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - Female MH - *Health Knowledge, Attitudes, Practice MH - Male MH - *Drinking MH - *Physical Education and Training/methods MH - *Dehydration/prevention & control MH - Thirst MH - Surveys and Questionnaires MH - Schools MH - Child Behavior PMC - PMC13259264 OTO - NOTNLM OT - behavior OT - board game OT - body hydration status OT - children OT - game-based intervention OT - health promotion COIS- All authors declare no conflicts of interest. EDAT- 2026/06/12 06:38 MHDA- 2026/06/15 11:33 PMCR- 2026/05/29 CRDT- 2026/06/12 01:11 PHST- 2026/04/16 00:00 [received] PHST- 2026/05/14 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/06/15 11:33 [medline] PHST- 2026/06/12 06:38 [pubmed] PHST- 2026/06/12 01:11 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - nu18111753 [pii] AID - nutrients-18-01753 [pii] AID - 10.3390/nu18111753 [doi] PST - epublish SO - Nutrients. 2026 May 29;18(11):1753. doi: 10.3390/nu18111753. PMID- 42280337 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 11 DP - 2026 May 26 TI - Maternal Methyl-Group Donor Intake and Neonatal Birth Size in Singleton IVF Pregnancies. LID - 10.3390/nu18111693 [doi] LID - 1693 AB - Background/Objectives: Maternal intake of methyl-group donors (MGD) during pregnancy may influence fetal development, yet its role in in vitro fertilization (IVF) pregnancies remains poorly understood. The aim of the present study was to investigate maternal intake of MGDs during late pregnancy and its association with neonatal outcomes in IVF versus spontaneously (S) conceived pregnancies. Methods: We assessed third-trimester, daily maternal intake of MGD (folate, betaine, choline, methionine, and folic acid) using a validated food-frequency questionnaire, and maternal supplement intake using a structured questionnaire. Methyl-donor nutrient score (MDNS) was calculated based on deciles of MGD intake. Serum folic acid and vitamin B12 concentrations were measured using standardized immunochemical assay. Predefined inclusion and exclusion criteria were applied. Anthropometric data were measured from singleton newborns (weight, length, head- and waist circumference, body composition) and mothers (height, weight, body composition) after delivery. Statistical analysis was conducted using R (4.1.2v). Results: 265 mother-child pairs were included in the study (IVF n = 83). Daily dietary intake of MGDs was similar between groups, but IVF mothers reported significantly higher daily folic acid (668.7 +/- 1050.9 vs. 418.8 +/- 419.2 microg, p = 0.0034) and vitamin B12 (11.07 +/- 31.58 vs. 7.95 +/- 29.00 microg, p = 0.0078) supplementation. Serum analyses were available in a subgroup (n = 131, IVF n = 61) of mothers, showing higher postpartum folate (IVF: 10.96 +/- 5.54 vs. S: 8.29 +/- 4.72 microg/L, p = 0.0064) and vitamin B12 (IVF: 288.22 +/- 113.82 vs. S: 233.70 +/- 78.23 ng/L, p = 0.0053). Maternal daily dietary choline intakes were significantly below recommendations (IVF: 251.9 +/- 98.5 mg, S: 243.8 +/- 106.8 mg). Among 151 singleton neonates (IVF n = 57), anthropometric parameters did not differ between IVF and spontaneously conceived groups and were not associated with MDNS tertiles. Conclusions: Maternal MGD intake during third trimester of pregnancy was not associated with neonatal anthropometric outcomes in singleton pregnancies. Consistently low dietary choline intake highlights a potential nutritional gap warranting improved dietary guidance and supplementation strategies. FAU - Bokor, Szilvia AU - Bokor S AD - Department of Pediatrics, Medical School, University of Pecs, 7623 Pecs, Hungary. AD - National Laboratory on Human Reproduction, University of Pecs, 7623 Pecs, Hungary. AD - Molecular Medicine Research Group, Szentagothai Research Centre, University of Pecs, 7623 Pecs, Hungary. FAU - Felso, Regina AU - Felso R AUID- ORCID: 0000-0001-5646-2093 AD - Department of Pediatrics, Medical School, University of Pecs, 7623 Pecs, Hungary. AD - National Laboratory on Human Reproduction, University of Pecs, 7623 Pecs, Hungary. AD - Hungarian Centre of Genomics and Bioinformatics, Szentagothai Research Centre, University of Pecs, 7623 Pecs, Hungary. FAU - Csolle, Ildiko AU - Csolle I AUID- ORCID: 0000-0003-3582-2541 AD - Department of Pediatrics, Medical School, University of Pecs, 7623 Pecs, Hungary. AD - National Laboratory on Human Reproduction, University of Pecs, 7623 Pecs, Hungary. AD - Cochrane Hungary, Medical School, University of Pecs, 7623 Pecs, Hungary. FAU - Olah, Ticia AU - Olah T AD - Department of Pediatrics, Medical School, University of Pecs, 7623 Pecs, Hungary. FAU - Szabo, Noemi AU - Szabo N AD - Department of Pediatrics, Medical School, University of Pecs, 7623 Pecs, Hungary. FAU - Herczeg, Robert AU - Herczeg R AD - Hungarian Centre of Genomics and Bioinformatics, Szentagothai Research Centre, University of Pecs, 7623 Pecs, Hungary. FAU - Gyenesei, Attila AU - Gyenesei A AD - Hungarian Centre of Genomics and Bioinformatics, Szentagothai Research Centre, University of Pecs, 7623 Pecs, Hungary. FAU - Vass, Reka Anna AU - Vass RA AD - National Laboratory on Human Reproduction, University of Pecs, 7623 Pecs, Hungary. AD - Department of Obstetrics and Gynecology, Medical School, University of Pecs, 7623 Pecs, Hungary. FAU - Funke, Simone AU - Funke S AD - National Laboratory on Human Reproduction, University of Pecs, 7623 Pecs, Hungary. AD - Department of Obstetrics and Gynecology, Medical School, University of Pecs, 7623 Pecs, Hungary. FAU - Ertl, Tibor AU - Ertl T AUID- ORCID: 0000-0003-3650-7084 AD - National Laboratory on Human Reproduction, University of Pecs, 7623 Pecs, Hungary. AD - Department of Obstetrics and Gynecology, Medical School, University of Pecs, 7623 Pecs, Hungary. FAU - Molnar, Denes AU - Molnar D AUID- ORCID: 0000-0002-3675-7019 AD - Department of Pediatrics, Medical School, University of Pecs, 7623 Pecs, Hungary. AD - National Laboratory on Human Reproduction, University of Pecs, 7623 Pecs, Hungary. AD - Molecular Medicine Research Group, Szentagothai Research Centre, University of Pecs, 7623 Pecs, Hungary. LA - eng PT - Journal Article DEP - 20260526 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 935E97BOY8 (Folic Acid) RN - N91BDP6H0X (Choline) RN - P6YC3EG204 (Vitamin B 12) RN - AE28F7PNPL (Methionine) RN - 3SCV180C9W (Betaine) SB - IM MH - Humans MH - Female MH - *Fertilization in Vitro MH - Pregnancy MH - Infant, Newborn MH - Adult MH - Folic Acid/administration & dosage/blood MH - *Birth Weight MH - Choline/administration & dosage MH - Vitamin B 12/blood/administration & dosage MH - *Maternal Nutritional Physiological Phenomena MH - *Dietary Supplements MH - Methionine/administration & dosage MH - Betaine/administration & dosage MH - Pregnancy Trimester, Third MH - Diet PMC - PMC13259345 OTO - NOTNLM OT - choline OT - folic acid OT - in vitro fertilization OT - methyl-group donor OT - newborn COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/06/12 06:38 MHDA- 2026/06/15 11:35 PMCR- 2026/05/26 CRDT- 2026/06/12 01:11 PHST- 2026/03/20 00:00 [received] PHST- 2026/05/22 00:00 [revised] PHST- 2026/05/23 00:00 [accepted] PHST- 2026/06/15 11:35 [medline] PHST- 2026/06/12 06:38 [pubmed] PHST- 2026/06/12 01:11 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - nu18111693 [pii] AID - nutrients-18-01693 [pii] AID - 10.3390/nu18111693 [doi] PST - epublish SO - Nutrients. 2026 May 26;18(11):1693. doi: 10.3390/nu18111693. PMID- 42280306 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 11 DP - 2026 May 22 TI - GLP-1 Receptor Agonists and Dual GIP/GLP-1 Receptor Agonists in Children and Adolescents with Obesity: Clinical Outcomes and the Impact of Nutritional and Behavioral Co-Interventions-A Systematic Review. LID - 10.3390/nu18111662 [doi] LID - 1662 AB - Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), originally developed for the treatment of type 2 diabetes (T2D), are increasingly used for the management of overweight and obesity in children and adolescents. However, the impact of concomitant lifestyle interventions, which vary in scope, structure, and intensity, remains unclear. Methods: A systematic search of PubMed, Scopus, and ClinicalTrials.gov was conducted from April to December 2025 (last update: 12 December 2025), in accordance with the PRISMA 2020 statement. Randomized and observational studies including patients aged 6-19 years with overweight or obesity, with or without T2D, treated with GLP-1 RAs or dual GIP/GLP-1 agonists, were included. Anthropometric outcomes, metabolic parameters, and the scope and structure of concomitant nutritional and behavioral interventions were assessed. Results: Fifteen studies (12 interventional [RCT/non-RCT] and 3 observational), including 1448 participants, were analyzed: liraglutide (n = 6), exenatide (n = 5), semaglutide (n = 1), dulaglutide (n = 1), tirzepatide (n = 1), and lixisenatide (n = 1). Intervention duration ranged from 6 to 68 weeks. Reported BMI reductions varied across studies and pharmacological agents, with semaglutide trials reporting reductions of up to -16.1%. Lifestyle interventions were heterogeneously reported, ranging from general dietary advice to structured, multidisciplinary programs including nutritional counseling, physical activity, and behavioral or family support. Due to heterogeneity in study design and reporting, the independent contribution of lifestyle interventions could not be determined. Conclusions: Available evidence suggests that GLP-1 RAs may represent an effective therapeutic option for children and adolescents with obesity and metabolic disorders. However, available evidence is largely derived from studies incorporating inconsistently reported lifestyle interventions, limiting the ability to disentangle pharmacological and lifestyle effects. Standardized reporting and studies specifically designed to assess their independent and combined effects are needed. Future research should standardize the reporting of lifestyle protocols (e.g., using TIDieR), incorporate validated measures of eating behavior, food preferences, and dietary intake, and use designs (e.g., factorial or stratified randomization of lifestyle intensity) that allow for the pharmacological and behavioral contributions to be quantified separately. This review highlights a critical and previously underexplored methodological gap regarding the structure and reporting of lifestyle co-interventions in pediatric GLP-1 trials. FAU - Mysliwczyk, Dominika AU - Mysliwczyk D AUID- ORCID: 0009-0004-2331-4106 AD - Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, Marii Sklodowskiej-Curie 3a, 80-210 Gdansk, Poland. FAU - Gofron, Krzysztof Ksawery AU - Gofron KK AD - Student Scientific Circle at Department of Clinical Nutrition, Medical University of Gdansk, Marii Sklodowskiej-Curie 3a, 80-210 Gdansk, Poland. FAU - Wasilewski, Andrzej AU - Wasilewski A AUID- ORCID: 0000-0001-9908-6921 AD - Student Scientific Association of Medical Chemistry and Immunochemistry, Wroclaw Medical University, Marii Sklodowskiej-Curie 48/50, 59-369 Wroclaw, Poland. FAU - Mysliwiec, Malgorzata AU - Mysliwiec M AUID- ORCID: 0000-0002-1533-8544 AD - Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, Marii Sklodowskiej-Curie 3a, 80-210 Gdansk, Poland. FAU - Wasilewska, Eliza AU - Wasilewska E AUID- ORCID: 0000-0002-5288-0586 AD - Department of Allergology, Medical University of Gdansk, Marii Sklodowskiej-Curie 3a, 80-210 Gdansk, Poland. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260522 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - WTT295HSY5 (dulaglutide) RN - 9P1872D4OL (Exenatide) RN - 59392-49-3 (Gastric Inhibitory Polypeptide) RN - 0 (Glucagon-Like Peptide-1 Receptor Agonists) RN - 62340-29-8 (Glucagon-Like Peptides) RN - 839I73S42A (Liraglutide) RN - 74O62BB01U (lixisenatide) RN - 53AXN4NNHX (Semaglutide) RN - OYN3CCI6QE (Tirzepatide) RN - 0 (Immunoglobulin Fc Fragments) RN - 0 (Recombinant Fusion Proteins) RN - 89750-14-1 (Glucagon-Like Peptide 1) SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Young Adult MH - *Behavior Therapy MH - Exenatide/therapeutic use MH - *Gastric Inhibitory Polypeptide/agonists MH - *Glucagon-Like Peptide-1 Receptor Agonists/therapeutic use MH - Glucagon-Like Peptides/analogs & derivatives/therapeutic use MH - Life Style MH - Liraglutide/therapeutic use MH - *Pediatric Obesity/therapy/drug therapy MH - Semaglutide/therapeutic use MH - Tirzepatide/therapeutic use MH - Treatment Outcome MH - Immunoglobulin Fc Fragments MH - Recombinant Fusion Proteins MH - Glucagon-Like Peptide 1/analogs & derivatives PMC - PMC13258732 OTO - NOTNLM OT - GLP-1 receptor agonists OT - adolescents OT - children OT - dulaglutide OT - exenatide OT - lifestyle intervention OT - liraglutide OT - nutritional counseling OT - pediatric obesity OT - semaglutide OT - systematic review OT - tirzepatide COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:39 MHDA- 2026/06/13 00:38 PMCR- 2026/05/22 CRDT- 2026/06/12 01:11 PHST- 2026/04/14 00:00 [received] PHST- 2026/05/20 00:00 [revised] PHST- 2026/05/20 00:00 [accepted] PHST- 2026/06/13 00:38 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 01:11 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - nu18111662 [pii] AID - nutrients-18-01662 [pii] AID - 10.3390/nu18111662 [doi] PST - epublish SO - Nutrients. 2026 May 22;18(11):1662. doi: 10.3390/nu18111662. PMID- 42280305 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 11 DP - 2026 May 22 TI - Methodological Approaches to Assess Disordered Eating Behaviors Related to Gluten-Free Diet Management in Children and Adolescents with Celiac Disease: A Scoping Review. LID - 10.3390/nu18111661 [doi] LID - 1661 AB - Objective: This scoping review aimed to map the methodological approaches used to assess disordered eating attitudes and behaviors in children and adolescents with celiac disease (CD). Methods: This review followed the Joanna Briggs Institute scoping review methodology and the PRISMA-ScR guidelines, including studies of children and adolescents with CD that used methodological approaches to assess disordered eating attitudes and behaviors in the context of the gluten-free diet (GFD). No restrictions were applied regarding geography, language, or year. Searches were conducted across 10 electronic databases. Data were descriptively analyzed and presented in tables or diagrams, with a narrative synthesis aligned to the review objective. Results: Studies from 13 countries were included and classified as quantitative (n = 16; 51.6%), qualitative (n = 11; 35.5%), or mixed-methods (n = 4; 12.9%). A total of 34 instruments were used, but only one was specifically designed to evaluate eating attitudes and behaviors in children and adolescents with CD. Conclusions: Analysis of disordered eating in children and adolescents with CD remains methodologically heterogeneous and evolving. Quantitative studies predominate but often rely on non-specific instruments that blur the distinction between adaptive dietary vigilance and disordered eating. Qualitative and mixed-methods approaches highlight lived experiences and reveal measurement gaps despite their higher costs. Progress depends on developing specific instruments for this population that better capture the complexity of GFD management across development. FAU - Schwantes, Marina de Cesaro AU - Schwantes MC AD - Department of Nutrition, Faculty of Health Sciences, Darcy Ribeiro University Campus, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Dusi, Rafaella AU - Dusi R AD - Department of Nutrition, Faculty of Health Sciences, Darcy Ribeiro University Campus, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Uenishi, Rosa Harumi AU - Uenishi RH AUID- ORCID: 0000-0002-2352-4355 AD - Interdisciplinary Laboratory of Biosciences, Faculty of Medicine, Darcy Ribeiro University Campus, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Ribeiro, Camila Dos Santos AU - Ribeiro CDS AUID- ORCID: 0000-0002-2770-1603 AD - Department of Nutrition, Faculty of Health Sciences, Darcy Ribeiro University Campus, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Zandonadi, Renata Puppin AU - Zandonadi RP AUID- ORCID: 0000-0003-0370-3089 AD - Department of Nutrition, Faculty of Health Sciences, Darcy Ribeiro University Campus, University of Brasilia, Brasilia 70910-900, Brazil. LA - eng GR - 00193-00000325/2026-83/Foundation for Research Support of the Federal District/ PT - Journal Article PT - Scoping Review DEP - 20260522 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Diet, Gluten-Free/psychology MH - *Celiac Disease/diet therapy/psychology MH - Adolescent MH - Child MH - *Feeding and Eating Disorders/diagnosis/psychology/etiology MH - *Feeding Behavior/psychology MH - Female MH - Male MH - Adolescent Behavior MH - Child Behavior PMC - PMC13258312 OTO - NOTNLM OT - behavioral nutrition OT - disordered eating OT - gluten-free diet OT - psychometrics COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:38 MHDA- 2026/06/13 06:38 PMCR- 2026/05/22 CRDT- 2026/06/12 01:11 PHST- 2026/04/14 00:00 [received] PHST- 2026/05/18 00:00 [revised] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/06/13 06:38 [medline] PHST- 2026/06/12 06:38 [pubmed] PHST- 2026/06/12 01:11 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - nu18111661 [pii] AID - nutrients-18-01661 [pii] AID - 10.3390/nu18111661 [doi] PST - epublish SO - Nutrients. 2026 May 22;18(11):1661. doi: 10.3390/nu18111661. PMID- 42279021 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260612 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 11 DP - 2026 May 28 TI - The ALT/AST Ratio as a Predictor of MASLD in Obese Children: A Comparative Analysis with Metabolic Indices Including HOMA-IR and TyG. LID - 10.3390/jcm15114160 [doi] LID - 4160 AB - Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is getting more prevalent in children with obesity, and simple and non-invasive biomarkers are needed for early detection. In this study, the discriminative performance of the ALT/AST ratio (AT index) for MASLD was evaluated in comparison with metabolic indices such as HOMA-IR and TyG derivatives. Methods: A total of 410 children with obesity aged 5-18 years were included in this prospective, multicenter cross-sectional study. Anthropometric measurements, laboratory data, and abdominal ultrasonography findings of the participants were evaluated. MASLD was diagnosed based on ultrasonographic findings. The discriminative performance of the indices was evaluated using ROC analysis, and factors independently associated with MASLD were assessed using multivariate logistic regression analysis. Results: BMI SDS, ALT, AT index, insulin, HOMA-IR, and TyG/ALT values were found to be significantly higher in the MASLD (+) group (p < 0.05). The AT index demonstrated statistically significant but modest discriminative ability for MASLD (AUC = 0.621; p < 0.001) and showed 70.5% sensitivity and 50.7% specificity at a cutoff value of >0.88. In the multivariate analysis, the AT index (OR: 3.401; 95% CI: 1.717-6.735; p < 0.001) and BMI SDS were identified as factors independently associated with MASLD.HOMA-IR and prolactin-related indices were not found to be significant as independent predictors. Conclusions: The ALT/AST ratio is a simple and accessible biomarker associated with MASLD in children with obesity. Although its discriminative performance is modest, its association with hepatic involvement and metabolic dysfunction suggests that it may provide supportive exploratory information in the evaluation of MASLD. However, further validation studies are required before broader clinical application. FAU - Kabukcu, Hilmi Onur AU - Kabukcu HO AUID- ORCID: 0000-0001-6869-9397 AD - Department of Pediatrics, Private Kastamonu Anatolia Hospital, 37200 Kastamonu, Turkey. FAU - Hazer, Ilhan AU - Hazer I AD - Department of Pediatric Endocrinology, Kutahya Health Sciences University, 43100 Kutahya, Turkey. LA - eng PT - Journal Article DEP - 20260528 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13257721 OTO - NOTNLM OT - AT index OT - MASLD OT - non-invasive biomarker COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:38 MHDA- 2026/06/12 06:39 PMCR- 2026/05/28 CRDT- 2026/06/12 01:06 PHST- 2026/05/06 00:00 [received] PHST- 2026/05/24 00:00 [revised] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/06/12 06:39 [medline] PHST- 2026/06/12 06:38 [pubmed] PHST- 2026/06/12 01:06 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - jcm15114160 [pii] AID - jcm-15-04160 [pii] AID - 10.3390/jcm15114160 [doi] PST - epublish SO - J Clin Med. 2026 May 28;15(11):4160. doi: 10.3390/jcm15114160. PMID- 42278890 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260612 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 11 DP - 2026 May 22 TI - Cardiovascular Risk and Modifiable Risk Factors in Shift-Working Healthcare Workers: A Gender-Stratified Cross-Sectional Study. LID - 10.3390/jcm15114028 [doi] LID - 4028 AB - Background: Shift-working healthcare workers (HCWs) are at elevated cardiovascular (CV) risk due to chronic circadian disruption; however, gender-stratified data on CV risk profiles and modifiable risk factor distribution by occupational exposure duration remain scarce in the Italian hospital setting. This cross-sectional study aimed to characterise the 10-year CV risk profile and the distribution of modifiable risk factors in a hospital-based sample of shift-working HCWs. Methods: A retrospective cross-sectional study was conducted using data from routine occupational health surveillance of shift-working HCWs at a large Italian hospital in Salento, Southern Italy (survey year: 2025). The 10-year CV risk was estimated using the CUORE Project algorithm, validated for the Italian population. Risk was stratified by gender, age group, and shift work duration. Multivariable logistic regression models, adjusted for age, marital status, and presence of children at home, evaluated associations between selected risk factors and CV risk category. The study was reported in accordance with STROBE guidelines. Results: Of 765 HCWs included (320 males, 445 females; mean age 49.3 +/- 8.5 years), male workers showed a significantly higher mean 10-year CV risk score (4.98 +/- 2.8 vs. 1.34 +/- 0.9; p < 0.05). Among male workers, the odds of moderate/high CV risk increased progressively with shift work duration (aOR 6.4 for >30 years). Males also showed significantly higher prevalence of arterial hypertension, overweight, and obesity across all strata. Conclusions: Male shift-working HCWs represent a higher-risk subgroup, characterised by a greater burden of modifiable cardiovascular risk factors. Integration of validated risk assessment tools into occupational health surveillance may support targeted preventive strategies in hospital settings. FAU - d'Ettorre, Gabriele AU - d'Ettorre G AUID- ORCID: 0000-0001-8714-1612 AD - Department of Occupational Medicine, Local Health Authority of Lecce, 73100 Lecce, Italy. FAU - Giannelli, Gianmarco AU - Giannelli G AD - Department of Occupational Medicine, Local Health Authority of Lecce, 73100 Lecce, Italy. FAU - Branda, Francesco AU - Branda F AUID- ORCID: 0000-0002-9485-3877 AD - Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, 00128 Rome, Italy. FAU - Loiacono, Giuseppe AU - Loiacono G AD - Department of Occupational Medicine, Local Health Authority of Lecce, 73100 Lecce, Italy. FAU - Calcagnile, Gianluigi AU - Calcagnile G AD - Department of Occupational Medicine, Local Health Authority of Lecce, 73100 Lecce, Italy. FAU - Centonze, Anna A AU - Centonze AA AD - Department of Occupational Medicine, Local Health Authority of Lecce, 73100 Lecce, Italy. FAU - Faggiano, Danilo AU - Faggiano D AD - Department of Occupational Medicine, Local Health Authority of Lecce, 73100 Lecce, Italy. FAU - d'Ettorre, Gabriella AU - d'Ettorre G AUID- ORCID: 0000-0002-3571-5677 AD - Department of Public Health and Infectious Diseases, University of Rome Sapienza, 00185 Rome, Italy. FAU - Ceccarelli, Giancarlo AU - Ceccarelli G AUID- ORCID: 0000-0001-5921-3180 AD - Department of Public Health and Infectious Diseases, University of Rome Sapienza, 00185 Rome, Italy. LA - eng PT - Journal Article DEP - 20260522 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13258224 OTO - NOTNLM OT - Italy OT - cardiovascular risk OT - cross-sectional study OT - healthcare workers OT - shift work COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:39 MHDA- 2026/06/12 06:40 PMCR- 2026/05/22 CRDT- 2026/06/12 01:06 PHST- 2026/04/13 00:00 [received] PHST- 2026/05/16 00:00 [revised] PHST- 2026/05/20 00:00 [accepted] PHST- 2026/06/12 06:40 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 01:06 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - jcm15114028 [pii] AID - jcm-15-04028 [pii] AID - 10.3390/jcm15114028 [doi] PST - epublish SO - J Clin Med. 2026 May 22;15(11):4028. doi: 10.3390/jcm15114028. PMID- 42275809 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260901 IS - 1873-4898 (Electronic) IS - 1477-5131 (Linking) VI - 22 IP - 5 DP - 2026 Oct TI - Quality of life and gender identity in females with congenital adrenal hyperplasia after genital restoration surgery: A single-center experience. PG - 106051 LID - S1477-5131(26)00330-X [pii] LID - 10.1016/j.jpurol.2026.106051 [doi] AB - BACKGROUND: Legislation restricting surgical interventions in children with differences of sex development (DSD) has intensified debate about female genital restoration surgery (FGRS) in patients with congenital adrenal hyperplasia (CAH). Long-term patient-reported outcomes are needed regarding the optimal timing of surgery. OBJECTIVE: We aimed to assess health-related quality of life (HRQoL), gender identity, and family satisfaction regarding surgical timing and outcome in females with CAH following genital restoration surgery. STUDY DESIGN: Cross-sectional survey of CAH patients who underwent surgery between January 2007 to December 2016 at our institution. Validated instruments (KINDL questionnaire for HRQoL, Utrecht Gender Dysphoria Scale, UGDS) and structured telephone interviews were employed. RESULTS: Data on HRQoL was available for 25 patients (self- and/or parent-reported) out of 56 eligible patients (45% response rate). Median age at first surgery was 6 months (range: 3-137 months). Patients' age at time of participation ranged from 2 to 28 years. All had 21-hydroxylase deficiency (92% salt-wasting form) with Prader grades ranging from II-V. Wound dehiscence requiring secondary suturing occurred in 15% of patients with primary surgery at our center, while only one (4%) patient developed vaginal stenosis after early primary vaginoplasty. Two additional patients (8%) with prior outside surgery required vaginal revision after FGRS at age 12. HRQoL scores were comparable to healthy reference populations across most age groups. Children aged 3-6 and adolescents and young adults showed no significant difference from reference values, while children aged 7-13 showed a slight elevation. None of five patients >/=14 years demonstrated gender dysphoria (all UGDS scores <40, threshold >/=40). 14 patients and families were also interviewed by telephone. All preferred early surgical timing. No family expressed regret about the decision or preferred delayed surgery. DISCUSSION: This study provides validated intermediate-term patient- and parent-reported outcomes after FGRS in CAH. Key limitations include the small sample size, single-center design, and young age of most patients. Selection bias may exist, though participating families included those who underwent revision surgery. The absence of a non-operated comparison group reflects current clinical reality, as nearly all CAH patients with urogenital sinus underwent surgical correction. CONCLUSIONS: Females with CAH reported normal HRQoL and a comfortable female gender identity after early FGRS. The patients and their families expressed a preference for early surgery. However, there is need for longer-term follow-up to assess sexual function and reproductive outcomes as well comparison of outcomes with a non-operated group. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Heidtmann, Friederike AU - Heidtmann F AD - Department of Pediatric Surgery, Jena University Hospital, 07747 Jena, Germany. Electronic address: friederike.heidtmann@med.uni-jena.de. FAU - Umbreit, Saskia AU - Umbreit S AD - Department of Pediatric Surgery, Jena University Hospital, 07747 Jena, Germany. Electronic address: saskia.umbreit@live.de. FAU - Eckoldt, Felicitas AU - Eckoldt F AD - Department of Pediatric Surgery, Jena University Hospital, 07747 Jena, Germany. Electronic address: felicitas.eckoldt@med.uni-jena.de. LA - eng PT - Journal Article DEP - 20260530 PL - England TA - J Pediatr Urol JT - Journal of pediatric urology JID - 101233150 SB - IM MH - Humans MH - Female MH - *Adrenal Hyperplasia, Congenital/surgery/psychology MH - Cross-Sectional Studies MH - Child MH - *Quality of Life MH - Adolescent MH - Child, Preschool MH - Adult MH - *Gender Identity MH - Young Adult MH - Infant MH - *Genitalia, Female/surgery MH - Gender Dysphoria MH - Treatment Outcome MH - *Plastic Surgery Procedures/methods MH - Retrospective Studies OTO - NOTNLM OT - Congenital adrenal hyperplasia OT - Female genital restoration surgery OT - Gender dysphoria OT - Patient reported outcomes OT - Quality of life OT - Urogenital sinus COIS- Conflict of interest statement None. EDAT- 2026/06/12 00:37 MHDA- 2026/09/01 05:41 CRDT- 2026/06/11 18:04 PHST- 2026/01/14 00:00 [received] PHST- 2026/04/26 00:00 [revised] PHST- 2026/05/23 00:00 [accepted] PHST- 2026/09/01 05:41 [medline] PHST- 2026/06/12 00:37 [pubmed] PHST- 2026/06/11 18:04 [entrez] AID - S1477-5131(26)00330-X [pii] AID - 10.1016/j.jpurol.2026.106051 [doi] PST - ppublish SO - J Pediatr Urol. 2026 Oct;22(5):106051. doi: 10.1016/j.jpurol.2026.106051. Epub 2026 May 30. PMID- 42275010 OWN - NLM STAT- Publisher LR - 20260611 IS - 2168-3824 (Electronic) IS - 0270-1367 (Linking) DP - 2026 Jun 11 TI - Examining Native Hawaiian and Pacific Islander Youth Attitudes Toward Physical Activity and Physical Education. PG - 1-8 LID - 10.1080/02701367.2026.2676647 [doi] AB - Native Hawaiian and Pacific Islander (NHPI) populations experience persistent disparities in physical activity (PA) and chronic disease, however, little is known about NHPI youths affective orientations toward PA and physical education (PE). The purpose of this study was to examine NHPI youths' attitudes toward PA and PE and their associations with intentions and behavior. Participants included 1,163 students in grades 4-12 from 11 schools (5 elementary, 6 secondary) across 2 islands in Hawai'i, with 57% identifying as NHPI. Students completed validated measures of PA attitudes, PE attitudes, PA intention, and self-reported PA. No differences emerged between NHPI and non-NHPI students across attitudes, intentions, or PA behavior. Within NHPI youth, positive PA attitudes were significantly associated with both PA intention and behavior, whereas PE attitudes were not. Findings challenge deficit-based assumptions that NHPI youth possess negative orientations toward PA. Instead, NHPI youth demonstrate positive PA attitudes that appear to operate independently of school-based PE experiences. This study contributes to the literature by highlighting the importance of distinguishing PA and PE attitudes within TPB-informed research and by underscoring the need for culturally responsive approaches that sustain positive PA dispositions across development. FAU - Hafoka, Crystal K AU - Hafoka CK AD - University of Hawai'i at Manoa. FAU - Centeio, Erin E AU - Centeio EE AUID- ORCID: 0000-0001-5465-4243 AD - University of Hawai'i at Manoa. FAU - Simonton, Kelly L AU - Simonton KL AUID- ORCID: 0000-0001-7261-2047 AD - University of Wyoming. FAU - Serna, A Ku'ulei AU - Serna AK AUID- ORCID: 0000-0001-9991-3544 AD - University of Hawai'i at Manoa. FAU - Mercier, Kevin J AU - Mercier KJ AUID- ORCID: 0000-0003-3505-2495 AD - Adelphi University. LA - eng PT - Journal Article DEP - 20260611 PL - United States TA - Res Q Exerc Sport JT - Research quarterly for exercise and sport JID - 8006373 SB - IM OTO - NOTNLM OT - Attitudes OT - Native Hawaiian and Pacific Islander Youth OT - culture OT - physical activity EDAT- 2026/06/11 12:38 MHDA- 2026/06/11 12:38 CRDT- 2026/06/11 11:33 PHST- 2026/06/11 12:38 [medline] PHST- 2026/06/11 12:38 [pubmed] PHST- 2026/06/11 11:33 [entrez] AID - 10.1080/02701367.2026.2676647 [doi] PST - aheadofprint SO - Res Q Exerc Sport. 2026 Jun 11:1-8. doi: 10.1080/02701367.2026.2676647. PMID- 42274442 OWN - NLM STAT- MEDLINE DCOM- 20260804 LR - 20260804 IS - 1878-2620 (Electronic) IS - 1499-4046 (Linking) VI - 58 IP - 8 DP - 2026 Aug TI - Creation and Psychometric Evaluation of the Teen Moms Child Feeding Readiness to Change Questionnaire for Teenage Mothers in Rural Suburbs of Nigeria. PG - 770-784 LID - S1499-4046(26)00125-9 [pii] LID - 10.1016/j.jneb.2026.05.001 [doi] AB - OBJECTIVE: To develop and validate the Teen Moms Child Feeding Readiness to Change Questionnaire for Sub-Saharan Africa for evaluating the transtheoretical stages of behavioral change related to infant and young child feeding. DESIGN: Cross-sectional study. SETTING: Communities with populations with low income in rural suburban areas of Abuja, Nigeria. PARTICIPANTS: Ten nutrition experts and 156 teenage mothers. METHODS: Nineteen items were generated on a 5-point Likert scale for responses. Two questions were eliminated after content evaluation by a panel of 10 nutrition experts and comprehensibility assessment by 6 teenage mothers. Unidimensionality and internal consistency reliability of the subscales were determined by factor loadings, Loevinger's scalability coefficient H and Molenaar Sijtsma rho coefficients. Construct validity was established via polytomous item response theory in 150 teenage mothers in rural suburbs of Abuja, Nigeria. RESULTS: The final questionnaire contained 11 questions in 3 subscales. All retained items had factor loadings > 0.4, Loevinger's coefficient H > 0.3, and rho coefficients > 0.6. All items displayed good discrimination (>/= 1) and difficulty parameters. Response characteristic curves indicated that the Likert option neither agree nor disagree was not frequently selected; thus, it was deleted. From scale information curves, it was observed that the contemplation, action, and maintenance subscales precisely estimated information for respondents with average ability to perform the latent construct. The precontemplation subscale contained more information for respondents with less than average abilities. CONCLUSIONS AND IMPLICATIONS: The Teen Moms Child Feeding Readiness to Change Questionnaire for Sub-Saharan Africa demonstrated promising preliminary evidence of validity and reliability for assessing Transtheoretical stages of change in teenage mothers. Further validation in larger and more diverse samples is warranted. CI - Copyright (c) 2026 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved. FAU - Sosanya, Mercy E AU - Sosanya ME AD - Department of Exercise and Nutrition Sciences, University at Buffalo, NY; Department of Nutrition and Dietetics, The Federal Polytechnic, Bauchi, Bauchi, Nigeria. Electronic address: mercysosanya@utexas.edu. FAU - Samuel, Temitope C AU - Samuel TC AD - Centre for Family Health Initiative, Abuja, Nigeria. FAU - Ugwu-Anyanwu, Krystal C AU - Ugwu-Anyanwu KC AD - Centre for Family Health Initiative, Abuja, Nigeria. FAU - Freeland-Graves, Jeanne H AU - Freeland-Graves JH AD - Department of Nutritional Sciences, University of Texas at Austin, Austin, TX. LA - eng PT - Journal Article PT - Validation Study DEP - 20260611 PL - United States TA - J Nutr Educ Behav JT - Journal of nutrition education and behavior JID - 101132622 SB - IM MH - Humans MH - Female MH - Nigeria MH - Adolescent MH - *Psychometrics MH - Surveys and Questionnaires/standards MH - Cross-Sectional Studies MH - Rural Population MH - Reproducibility of Results MH - *Adolescent Mothers/psychology/statistics & numerical data MH - Infant MH - *Feeding Behavior/psychology MH - Mothers OTO - NOTNLM OT - adolescent mothers OT - infant and young child feeding OT - psychometric validation OT - readiness to change OT - transtheoretical model EDAT- 2026/06/11 12:39 MHDA- 2026/08/09 15:17 CRDT- 2026/06/11 10:45 PHST- 2025/03/17 00:00 [received] PHST- 2026/04/09 00:00 [revised] PHST- 2026/05/04 00:00 [accepted] PHST- 2026/08/09 15:17 [medline] PHST- 2026/06/11 12:39 [pubmed] PHST- 2026/06/11 10:45 [entrez] AID - S1499-4046(26)00125-9 [pii] AID - 10.1016/j.jneb.2026.05.001 [doi] PST - ppublish SO - J Nutr Educ Behav. 2026 Aug;58(8):770-784. doi: 10.1016/j.jneb.2026.05.001. Epub 2026 Jun 11. PMID- 42271444 OWN - NLM STAT- MEDLINE DCOM- 20260816 LR - 20260819 IS - 1477-7525 (Electronic) IS - 1477-7525 (Linking) VI - 24 IP - 1 DP - 2026 Jun 10 TI - Predicting poor health-related quality of life among Chinese adolescents using explainable machine learning: the role of school adjustment, family context, and lifestyle factors. LID - 10.1186/s12955-026-02568-y [doi] LID - 105 AB - BACKGROUND: Adolescents' health-related quality of life (HRQoL) is influenced by multiple domains, including school, family, and individual lifestyle. However, evidence remains limited on accurately predicting adolescent HRQoL and identifying modifiable determinants. This study aimed to develop a machine-learning prediction model for adolescent HRQoL and to determine key contextual factors associated with low quality of life. METHODS: This cross-sectional study included 20,236 adolescents (51.71% female; mean age 15.97 years). HRQoL was assessed using the validated Quality of Life Scale for Children and Adolescents (QLSCA). Twenty predictors covering school adjustment, family characteristics, and health behaviours were entered into 9 machine-learning classifiers and logistic regression. Feature contributions were examined using permutation importance, partial dependence plots (PDPs), and SHapley Additive exPlanations (SHAP). Stratified analyses by sex and school stage were conducted to identify group-specific determinants. RESULTS: School adjustment was the primary predictor of HRQoL, with self-management and peer relations contributing most. Family factors ranked next, particularly more frequent exercise with parents, which was associated with higher HRQoL. Among lifestyle behaviours, higher physical activity and healthier dietary patterns were associated with better HRQoL, whereas excessive screen time was associated with poorer HRQoL. In stratified analyses, peer relations and physical activity were more influential among boys, while self-management, exercising with parents, and adequate sleep contributed more among girls. Middle school students showed more adverse associations with disruptive/antisocial behaviours and screen time, whereas high school students derived greater benefits from family interaction and health behaviours. CONCLUSIONS: Explainable machine-learning analyses highlight school adjustment as a central correlate of adolescent HRQoL, alongside family characteristics and health behaviours. These findings provide multidimensional evidence to support targeted interventions in educational, family, and public health settings to improve adolescents' HRQoL. CI - (c) 2026. The Author(s). FAU - Zhao, Liangyu AU - Zhao L AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Gao, Yan AU - Gao Y AD - School of Physical Education, Shandong University, Jinan, 250061, China. gaoyanluck@sdu.edu.cn. FAU - Liu, Chenchen AU - Liu C AD - School of Medical Information Engineering, Jining Medical University, Jining, 272067, China. FAU - Zhang, Zeqi AU - Zhang Z AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Yang, Yuke AU - Yang Y AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Hu, Yining AU - Hu Y AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Sui, Wenze AU - Sui W AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Ma, Sen AU - Ma S AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Zhang, Shuoqin AU - Zhang S AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Lai, Xinxin AU - Lai X AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Wang, Zhiying AU - Wang Z AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Yang, Zhiwen AU - Yang Z AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Yi, Xiangren AU - Yi X AD - School of Physical Education, Shandong University, Jinan, 250061, China. LA - eng GR - 21BTY054/National Social Science Fund of China/ GR - 2024YFC3607603/National Key Research and Development Program of China/ GR - 202409A07/National Population Health Data Center/ PT - Journal Article DEP - 20260610 PL - England TA - Health Qual Life Outcomes JT - Health and quality of life outcomes JID - 101153626 RN - Chinese people SB - IM MH - Humans MH - Female MH - Adolescent MH - *Quality of Life/psychology MH - Male MH - Cross-Sectional Studies MH - China MH - *Life Style MH - *Machine Learning MH - Health Behavior MH - Schools MH - East Asian People PMC - PMC13479416 OTO - NOTNLM OT - Adolescents OT - Family characteristics OT - Health-related quality of life OT - Healthy lifestyle OT - Machine learning OT - School adjustment COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of Shandong University [Approval No. 20180517]. Adolescents and their parents/guardians gave informed consent prior to taking part in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/11 06:37 MHDA- 2026/08/17 05:38 PMCR- 2026/06/10 CRDT- 2026/06/11 00:14 PHST- 2026/02/06 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/08/17 05:38 [medline] PHST- 2026/06/11 06:37 [pubmed] PHST- 2026/06/11 00:14 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.1186/s12955-026-02568-y [pii] AID - 2568 [pii] AID - 10.1186/s12955-026-02568-y [doi] PST - epublish SO - Health Qual Life Outcomes. 2026 Jun 10;24(1):105. doi: 10.1186/s12955-026-02568-y. PMID- 42270539 OWN - NLM STAT- MEDLINE DCOM- 20260624 LR - 20260624 IS - 2341-2879 (Electronic) IS - 2341-2879 (Linking) VI - 104 IP - 6 DP - 2026 Jun TI - Neck circumference in screening for elevated blood pressure. PG - 504226 LID - S2341-2879(26)00183-3 [pii] LID - 10.1016/j.anpede.2026.504226 [doi] AB - INTRODUCTION: Elevated blood pressure (EBP) in childhood is associated with excess adiposity. The aim was to compare anthropometric and body composition indicators to identify EBP (>/=90th percentile) in schoolchildren. MATERIALS AND METHODS: Cross-sectional study in 497 rural Andalusian schoolchildren (6-15 years). Weight, height, circumferences (waist and neck) and skinfolds (bicipital, tricipital, subscapular, and suprailiac) were recorded to calculate body mass index, waist-to-height ratio, the sum of 4 skinfolds and body fat percentage. Blood pressure was measured by oscillometry (3 readings; mean of the last 2) and classified using Spanish age- and sex-specific references (>/=90th percentile for systolic and/or diastolic blood pressure). Age- and sex-adjusted logistic models and sex-stratified analyses of discrimination and calibration were performed; optimal cut-offs were derived using the Youden index. RESULTS: The prevalence of EBP was 5.8% and increased with excess weight, particularly in girls. After multivariable adjustment, neck circumference (NC) was the indicator most consistently associated with EBP. Discriminative ability was moderate in boys and high in girls, with optimal cut-offs of 29.15 cm and 30.65 cm, respectively. CONCLUSIONS: NC is a simple, low-cost measure that may complement traditional indicators for EBP screening in school settings and primary care; the proposed cut-offs require external validation. CI - Copyright (c) 2026 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L.U. All rights reserved. FAU - Recio Anon, Carlos AU - Recio Anon C AD - Dispositivo de Cuidados Criticos y Urgencias, Distrito Sanitario Cordoba Guadalquivir, Cordoba, Spain; Grupo de Investigacion EPINUT Ref. 929325, Universidad Complutense de Madrid, Madrid, Spain. Electronic address: crecio02@ucm.es. FAU - Sastre Dominguez, Manuel Alejandro AU - Sastre Dominguez MA AD - Servicio de Pediatria, Hospital Universitario Reina Sofia de Cordoba, Cordoba, Spain. FAU - Carracedo Anon, Julia AU - Carracedo Anon J AD - Departamento de Genetica, Fisiologia y Microbiologia, Facultad de Ciencias Biologicas, Universidad Complutense de Madrid, Instituto de Investigacion Sanitaria Hospital 12 de Octubre (IMAS12), Madrid, Spain. FAU - Gonzalez Martin, Antonio AU - Gonzalez Martin A AD - Departamento de Biodiversidad, Ecologia y Evolucion, Facultad de Ciencias Biologicas, Universidad Complutense de Madrid, Madrid, Spain. FAU - Marrodan Serrano, Maria Dolores AU - Marrodan Serrano MD AD - Grupo de Investigacion EPINUT Ref. 929325, Universidad Complutense de Madrid, Madrid, Spain; Departamento de Biodiversidad, Ecologia y Evolucion, Facultad de Ciencias Biologicas, Universidad Complutense de Madrid, Madrid, Spain. LA - eng PT - Journal Article DEP - 20260610 PL - Spain TA - An Pediatr (Engl Ed) JT - Anales de pediatria JID - 101765626 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - *Neck/anatomy & histology MH - Female MH - Child MH - *Hypertension/diagnosis/epidemiology MH - Adolescent MH - Mass Screening/methods OTO - NOTNLM OT - Anthropometry OT - Antropometria OT - Blood pressure OT - Cuello OT - Neck OT - Obesidad infantil OT - Pediatric obesity OT - Pediatrics OT - Pediatria OT - Presion arterial COIS- Declaration of competing interest The authors have no conflicts of interest to declare. EDAT- 2026/06/11 05:42 MHDA- 2026/06/25 00:33 CRDT- 2026/06/10 22:51 PHST- 2026/02/04 00:00 [received] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/06/25 00:33 [medline] PHST- 2026/06/11 05:42 [pubmed] PHST- 2026/06/10 22:51 [entrez] AID - S2341-2879(26)00183-3 [pii] AID - 10.1016/j.anpede.2026.504226 [doi] PST - ppublish SO - An Pediatr (Engl Ed). 2026 Jun;104(6):504226. doi: 10.1016/j.anpede.2026.504226. Epub 2026 Jun 10. PMID- 42269963 OWN - NLM STAT- MEDLINE DCOM- 20260724 LR - 20260821 IS - 1878-1780 (Electronic) IS - 1262-3636 (Linking) VI - 52 IP - 4 DP - 2026 Jul TI - Persistent burden and management gaps of hypoglycemia in pediatric type 1 diabetes: insights from the Epi-GLUREDIA Study. PG - 101774 LID - S1262-3636(26)00053-4 [pii] LID - 10.1016/j.diabet.2026.101774 [doi] AB - BACKGROUND/OBJECTIVES: - Despite advances in automated insulin delivery, hypoglycemia remains a major challenge in pediatric type 1 diabetes. We aimed to characterize, in real-world practice, the burden, awareness, and daily-life impact of hypoglycemia and severe hypoglycemia (SH), and to identify gaps in perception and management. METHODS: - We conducted a prospective, descriptive, multicenter study using the new GLUREDIA questionnaire, administered during routine pediatric diabetes visits across six centers in Belgium and Luxembourg. This structured, study-specific, semi-quantitative tool assessed hypoglycemia frequency, symptom severity, perceived glycemic thresholds, SH history and management, and post-SH behavioral adaptations. Hypoglycemia awareness was evaluated using items aligned with Clarke score domains. RESULTS: - Among 232 participants, 55.9% reported hypoglycemia at least weekly, with moderate-to-high symptom severity. Cognitive and daily-life symptoms (impaired focus, fatigue, hunger, tremor) were reported by >60% and interfered with activities. Hypoglycemia was identified as the dominant disease burden by 39.7% of participants. Hypoglycemia-related symptom burden remained substantial and was not fully explained by CGM-derived metrics. SH was reported by 45.7%, without clear cause in 29.1%. Recommended management, including glucagon use, was inconsistently applied, even in recurrent SH. Following SH, participants reported insulin dose reductions (27.4%), increased sugar intake (21.1%), and avoidance of physical activities (22.1%), as adaptations. The Epi-GLUREDIA questionnaire demonstrated promising discriminative ability against the Clarke score (AUC = 0.84), supporting its construct validity. CONCLUSIONS: - Despite advances in diabetes technology, hypoglycemia remains highly prevalent, impactful, and often poorly anticipated in pediatric type 1 diabetes. Gaps in SH management and hypoglycemia awareness, together with post-event adaptations, highlight the need for integrated strategies combining education, behavioral support, optimized use of technologies, and improved implementation of guidelines, including appropriate glucagon use, to improve hypoglycemia safety, recognition, and long-term outcomes in pediatric type 1 diabetes. SUMMARY: Hypoglycemia remains frequent and impactful in pediatric type 1 diabetes, with variable symptom thresholds, unexplained severe hypoglycemia, management gaps, and post-event adaptations that may impair glycemic control. CI - Copyright (c) 2026 The Authors. Published by Elsevier Masson SAS.. All rights reserved. FAU - Beckers, Maude AU - Beckers M AD - Specialized Pediatrics Service, Cliniques universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium; UCLouvain, Institut de Recherche Experimentale et Clinique, EDIN laboratory, Avenue Hippocrate 55, 1200 Brussels, Belgium. FAU - Harvengt, Antoine AU - Harvengt A AD - Specialized Pediatrics Service, Cliniques universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium; UCLouvain, Institut de Recherche Experimentale et Clinique, EDIN laboratory, Avenue Hippocrate 55, 1200 Brussels, Belgium. FAU - Schoenmaeckers, Gaetan de Valensart AU - Schoenmaeckers GV AD - Specialized Pediatrics Service, Cliniques universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium. FAU - Beckers, Dominique AU - Beckers D AD - Pediatric Endocrinology and Diabetology, CHU UCL Namur, Rue Dr Gaston Therasse 1, 5530 Yvoir. FAU - Boutsen, Laure AU - Boutsen L AD - Pediatric Endocrinology and Diabetology, CHU UCL Namur, Rue Dr Gaston Therasse 1, 5530 Yvoir; UCLouvain, Institut de Recherche Experimentale et Clinique, EDIN laboratory, Avenue Hippocrate 55, 1200 Brussels, Belgium. FAU - Mouraux, Thierry AU - Mouraux T AD - Pediatric Endocrinology and Diabetology, CHU UCL Namur, Rue Dr Gaston Therasse 1, 5530 Yvoir. FAU - Gies, Inge AU - Gies I AD - Pediatric Department, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium; Vitality Research Group, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels. FAU - Staels, Willem AU - Staels W AD - Pediatric Department, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium; Beta Cell Neogenesis (BENE) research group, Genetics Reproduction and Development (GRAD), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels. FAU - Vanbesien, Jesse AU - Vanbesien J AD - Pediatric Department, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium; Vitality Research Group, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels. FAU - Lysy, Philippe A AU - Lysy PA AD - Specialized Pediatrics Service, Cliniques universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium; UCLouvain, Institut de Recherche Experimentale et Clinique, EDIN laboratory, Avenue Hippocrate 55, 1200 Brussels, Belgium. Electronic address: philippe.lysy@uclouvain.be. LA - eng PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20260610 PL - France TA - Diabetes Metab JT - Diabetes & metabolism JID - 9607599 RN - 0 (Hypoglycemic Agents) RN - 0 (Insulin) SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Cost of Illness MH - *Diabetes Mellitus, Type 1/drug therapy/complications/blood MH - *Hypoglycemia/epidemiology/chemically induced/therapy MH - *Hypoglycemic Agents/adverse effects/therapeutic use/administration & dosage MH - Insulin/adverse effects/administration & dosage/therapeutic use MH - Prospective Studies MH - Surveys and Questionnaires OTO - NOTNLM OT - Adolescents/Children OT - Glucagon OT - Hypoglycemia OT - Hypoglycemia Awareness OT - Pediatric Diabetes OT - Severe Hypoglycemia OT - Type 1 Diabetes COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Philippe A. Lysy reports financial support was provided by The Leona M and Harry B Helmsley Charitable Trust. Maude Beckers reports financial support was provided by Fund for Scientific Research. Philippe A. Lysy reports financial support was provided by Saint-Luc Foundation. Willem Staels reports a relationship with Research Foundation Flanders that includes: funding grants. Willem Staels reports a relationship with Breakthrough T1D that includes: funding grants. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/11 05:41 MHDA- 2026/07/25 00:35 CRDT- 2026/06/10 19:58 PHST- 2026/04/02 00:00 [received] PHST- 2026/05/29 00:00 [revised] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/07/25 00:35 [medline] PHST- 2026/06/11 05:41 [pubmed] PHST- 2026/06/10 19:58 [entrez] AID - S1262-3636(26)00053-4 [pii] AID - 10.1016/j.diabet.2026.101774 [doi] PST - ppublish SO - Diabetes Metab. 2026 Jul;52(4):101774. doi: 10.1016/j.diabet.2026.101774. Epub 2026 Jun 10. PMID- 42269380 OWN - NLM STAT- MEDLINE DCOM- 20260722 LR - 20260722 IS - 1618-131X (Electronic) IS - 1438-4639 (Linking) VI - 276 DP - 2026 Jul TI - Uncovering hidden beta-adrenergic agonist exposure from meat consumption through nationally representative human biomonitoring in Taiwan. PG - 114849 LID - S1438-4639(26)00109-4 [pii] LID - 10.1016/j.ijheh.2026.114849 [doi] AB - BACKGROUND: Despite stringent bans on clenbuterol in livestock production, its prolonged half-life poses a potential risk for human bioaccumulation. Conversely, legally permitted additives like ractopamine undergo rapid metabolism. This study utilized human biomonitoring (HBM) to uncover hidden beta-adrenergic agonist exposures in Taiwan, contrasting internal body burdens with traditional market surveillance data. METHODS: We analyzed data from a nationally representative sample of 1554 participants in the 2019 Taiwan Human BioMonitoring Program. Spot urine samples were tested for eight beta-adrenergic agonists using ultra-trace isotope dilution online SPE-LC-MS/MS. Dietary habits, including meat and egg consumption frequencies, were assessed via validated food frequency questionnaires. Associations were evaluated using survey-weighted logistic regression models. RESULTS: Clenbuterol was the most frequently detected beta-adrenergic agonist (31.4%), starkly contrasting with its zero-detection rate in recent official market surveillance. In contrast, the legally permitted ractopamine was detected in only 4.2% of samples. After adjusting for confounders, urinary clenbuterol detection showed a significant association with red meat consumption (adjusted odds ratio = 1.39, 95% CI: 1.08-1.79, p = 0.011). CONCLUSIONS: A significant portion of the Taiwanese general population experiences hidden, low-dose exposure to clenbuterol. This prevalence highlights a critical gap between routine regulatory testing limits and the bioaccumulation potential of clenbuterol from red meat consumption. HBM proves essential for uncovering these hidden exposures. Integrating ultra-trace HBM data into public health frameworks is necessary to accurately assess dietary risks and effectively manage food safety policies. CI - Copyright (c) 2026 Elsevier GmbH. All rights reserved. FAU - Liao, Ho-Tang AU - Liao HT AD - National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan. FAU - Peng, Tzu-Hsuan AU - Peng TH AD - Institute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health, Taipei, Taiwan. FAU - Wang, Chien-Jen AU - Wang CJ AD - National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan. FAU - Hsu, Jing-Fang AU - Hsu JF AD - Department of Occupational Safety and Health, Chung Shan Medical University, Taichung, Taiwan; Department of Occupational Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan. FAU - Lin, Ching-Chun AU - Lin CC AD - Institute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health, Taipei, Taiwan. FAU - Pan, Wen-Harn AU - Pan WH AD - College of Public Health, Taipei Medical University, New Taipei, Taiwan. FAU - Chia, Shu-Lih AU - Chia SL AD - Ministry of Health and Welfare, Taipei, Taiwan. FAU - Chen, Pau-Chung AU - Chen PC AD - National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan; Institute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health, Taipei, Taiwan; Department of Public Health, National Taiwan University College of Public Health, Taipei, Taiwan; Department of Environmental and Occupational Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan. Electronic address: pchen@ntu.edu.tw. LA - eng PT - Journal Article DEP - 20260610 PL - Germany TA - Int J Hyg Environ Health JT - International journal of hygiene and environmental health JID - 100898843 RN - 0 (Adrenergic beta-Agonists) RN - XTZ6AXU7KN (Clenbuterol) RN - 57370OZ3P1 (ractopamine) RN - 0 (Phenethylamines) SB - IM MH - Humans MH - *Adrenergic beta-Agonists/urine MH - Taiwan MH - Biological Monitoring MH - Female MH - Adult MH - Male MH - *Meat MH - Middle Aged MH - Clenbuterol/urine MH - Food Contamination/analysis MH - Young Adult MH - *Dietary Exposure/analysis MH - Aged MH - Phenethylamines/urine MH - Adolescent MH - Environmental Exposure OTO - NOTNLM OT - Dietary exposure OT - General population OT - Human biomonitoring OT - Leanness-enhancing agent OT - beta-adrenergic agonist COIS- Declaration of competing interest The authors declare no conflict of interest. EDAT- 2026/06/11 05:43 MHDA- 2026/07/23 05:36 CRDT- 2026/06/10 18:06 PHST- 2026/03/18 00:00 [received] PHST- 2026/05/30 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/07/23 05:36 [medline] PHST- 2026/06/11 05:43 [pubmed] PHST- 2026/06/10 18:06 [entrez] AID - S1438-4639(26)00109-4 [pii] AID - 10.1016/j.ijheh.2026.114849 [doi] PST - ppublish SO - Int J Hyg Environ Health. 2026 Jul;276:114849. doi: 10.1016/j.ijheh.2026.114849. Epub 2026 Jun 10. PMID- 42268871 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 6 DP - 2026 TI - Geospatial variation and machine learning approaches to predict open defecation practice in Zambia. PG - e0350923 LID - 10.1371/journal.pone.0350923 [doi] LID - e0350923 AB - BACKGROUND: Open defecation is the disposal of human feces in fields, bushes, forests, open waterways, beaches, and other open areas. It worsens the environment, contaminates drinking water sources, causes malnutrition and low school attendance in children, and aids in the spread of diseases like cholera, diarrhea, dysentery, typhoid, polio, and hepatitis A. The purpose of this study was geospatial variation and machine learning approaches to predict open defecation in Zambia. METHODS: This study used secondary data analysis from the cross-sectional Zambia Demographic and Health Survey (ZMDHS) 2024. Spatial distribution, spatial autocorrelation, incremental autocorrelation, spatial interpolation, and hot spot area detection were all examined using ArcGIS 10.7. Python was used to identify the features of open defecation practice using machine-learning algorithms. We carried out an 80/20% data split, one-hot data encoding, data transformation and integration, data cleaning, and 10-fold stratified cross-validation. This study employed seven machine-learning algorithms, including adaptive boosting, cat boosting, random forest, light boosting, extreme gradient boosting, decision tree and logistic regression. RESULTS: Among 12,808 households in Zambia, 12.1% were practiced open defecation. Spatial analysis revealed significant clustering, with hot spots concentrated in Southern, Western and Eastern regions, highlighting areas in urgent need of intervention. Machine learning models were applied to predict open defecation practices, with light gradient boost performing the best model with AUC of 83.83%. From this study, 198 true positives were generated by the model for the classification of open defecation practice, accurately identifying those who reported engaging in this behavior. CONCLUSION: Wealth index, access to treated water, access to electricity, educational level, and age of household head, access to media, and region were the most significant features of open defecation practice. Governments, NGOs, policy makers, and researchers can use these data to create targeted interventions for improving health and environmental sanitation based on the gaps and disparities discovered. CI - Copyright: (c) 2026 Birlie et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Birlie, Andualem Addisu AU - Birlie AA AUID- ORCID: 0009-0000-2337-0192 AD - Department of Health Informatics, College of Medicine and Health Science, Samara University, Samara, Ethiopia. FAU - Meshesha, Nega Abebe AU - Meshesha NA AD - Department of Public Health, Institute of Health, Dambi Dollo University, Dambi Dollo, Ethiopia. FAU - Tizie, Sefefe Birhanu AU - Tizie SB AD - Department of Health Informatics, College of Medicine and Health Science, Debre Markos University, Debre Markos, Ethiopia. FAU - Wondie, Smegnew Gichew AU - Wondie SG AD - Department of Public Health, College of Medicine and Health Science, Mizan Tepi University, Mizan Aman, Ethiopia. FAU - Teshome, Selamawit Gashaw AU - Teshome SG AD - School of Public Health, Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia. FAU - Bedada, Tesfaye Deribe AU - Bedada TD AUID- ORCID: 0009-0003-7102-5790 AD - Department of Health Informatics, School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. FAU - Muluneh, Ayana Alebachew AU - Muluneh AA AD - Department of Health Informatics, College of Medicine and Health Science, Wollo University, Dessie, Ethiopia. FAU - Eticha, Biruktawit Lelisa AU - Eticha BL AD - Department of Health Informatics, School of Public Health, College of Medicine and Health Science, Wachemo University, Hossana, Ethiopia. FAU - Dube, Geleta Nenko AU - Dube GN AD - School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. FAU - Wodessa, Gelgelo AU - Wodessa G AD - School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. FAU - Mengistie, Muluken Belachew AU - Mengistie MB AUID- ORCID: 0000-0002-0606-9477 AD - Department of Health Informatics, College of Medicine and Health Science, Debre Markos University, Debre Markos, Ethiopia. LA - eng PT - Journal Article DEP - 20260610 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Zambia MH - Humans MH - *Machine Learning MH - Boosting Machine Learning Algorithms MH - Random Forest MH - *Defecation MH - Predictive Learning Models MH - Cross-Sectional Studies MH - Classification Algorithms MH - Prediction Algorithms MH - Spatial Analysis PMC - PMC13252813 COIS- The authors declare that there are no competing interests. EDAT- 2026/06/11 05:39 MHDA- 2026/06/15 11:31 PMCR- 2026/06/10 CRDT- 2026/06/10 13:43 PHST- 2026/03/05 00:00 [received] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/06/15 11:31 [medline] PHST- 2026/06/11 05:39 [pubmed] PHST- 2026/06/10 13:43 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - PONE-D-26-11222 [pii] AID - 10.1371/journal.pone.0350923 [doi] PST - epublish SO - PLoS One. 2026 Jun 10;21(6):e0350923. doi: 10.1371/journal.pone.0350923. eCollection 2026. PMID- 42268692 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260624 IS - 1938-2359 (Electronic) IS - 0090-4481 (Linking) VI - 55 IP - 6 DP - 2026 Jun TI - Risks and Benefits of Social Media on Adolescent Health. PG - e222-e228 LID - 10.3928/19382359-20260223-02 [doi] AB - Adolescents increasingly construct aspects of their identity and form relationships by interacting on social media; yet, clinical frameworks lag behind technological change. This review synthesizes recent evidence on how platform design, usage patterns, and individual differences influence both benefits and harms. Problematic use is associated with sleep disturbance, mood and attention disorders, body image concerns, cyberbul-lying, and exposure to self-harm content, with disproportionate burdens for female patients and youth who are marginalized. Meanwhile, online communities can foster connection, coping, and help seeking, particularly for adolescents facing stigma or isolation. We propose a structured, developmentally informed workflow incorporating brief screening, targeted use of validated tools, and collaborative family media planning. Rather than centering total screen time, we emphasize function-focused, harm-reduction approaches to harness digital platforms as a tool for adolescent health. FAU - Sellars, Suzanna E AU - Sellars SE AD - Department of Pediatrics, Craig Dalsimer Division of Adolescent Medicine, Children's Hospital of Philadelphia, Pennsylvania. FAU - Kabra, Rashi AU - Kabra R AD - Department of Pediatrics, Craig Dalsimer Division of Adolescent Medicine, Children's Hospital of Philadelphia, Pennsylvania. LA - eng PT - Journal Article PT - Review DEP - 20260601 PL - United States TA - Pediatr Ann JT - Pediatric annals JID - 0356657 SB - IM MH - Adolescent MH - Humans MH - *Adolescent Behavior/psychology MH - *Adolescent Health MH - *Digital Media MH - *Media Exposure MH - *Social Media COIS- Disclosure: SES has received support for attending meetings and travel from Children's Hospital of Philadelphia (CHOP) GME (Graduate Medical Education) and Leadership and Education in Adolescent Health Program at CHOP. RK has received support for attending meetings and travel from CHOP. EDAT- 2026/06/11 05:39 MHDA- 2026/06/13 00:40 CRDT- 2026/06/10 12:04 PHST- 2026/06/13 00:40 [medline] PHST- 2026/06/11 05:39 [pubmed] PHST- 2026/06/10 12:04 [entrez] AID - 10.3928/19382359-20260223-02 [doi] PST - ppublish SO - Pediatr Ann. 2026 Jun;55(6):e222-e228. doi: 10.3928/19382359-20260223-02. Epub 2026 Jun 1. PMID- 42267217 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260610 LR - 20260813 IS - 2071-9736 (Electronic) IS - 1025-9848 (Print) IS - 1025-9848 (Linking) VI - 31 DP - 2026 TI - Prevalence of overweight, obesity and central adiposity among grade seven adolescents in urban Tshwane, South Africa. PG - 3328 LID - 10.4102/hsag.v31i0.3328 [doi] LID - 3328 AB - BACKGROUND: The global increase in overweight and obesity among adolescents is a significant public health priority, especially in low- and middle-income countries. In South Africa, urbanisation and lifestyle changes have exacerbated this challenge, but there is a lack of disaggregated data available to inform effective local responses. AIM: To assess and describe the prevalence of overweight, obesity and central adiposity in Grade seven adolescents in urban Tshwane, South Africa, and explore its association with socioeconomic characteristics. SETTING: The study was conducted in five diverse fee-paying public primary schools in urban Tshwane, Gauteng province. METHODS: A quantitative, descriptive cross-sectional design recruited 164 adolescents aged 11-14 years. Anthropometric measures were performed according to World Health Organization (WHO) standards. These included a survey of height and weight to derive body mass index (BMI-for-age) z-scores, as well as waist circumference to height ratio (WHtR). Socioeconomic status was assessed using the validated Family Affluence Scale. Data analysis included descriptive statistics and chi-square tests to determine the association between categorical variables. RESULTS: The combined prevalence of overweight and obesity was 23.7%, with a greater burden among girls (36.4% of 12 year olds) compared to boys (16.7%). The risk of central adiposity (WHtR >/= 0.5) was found in 25% of participants, with 7.3% at very high risk. Household income was significantly associated with obesity (p = 0.043), while parental education was not statistically significant. CONCLUSION: The high prevalence of excess adiposity, particularly among female adolescents, indicates an emerging cardiometabolic risk profile among the group. CONTRIBUTION: This study addresses a critical gap in South African public health literature by providing locally specific, disaggregated data on the nutritional status of urban adolescents in Tshwane, a cohort that is underrepresented in contrast to conventional rural or national surveys. CI - (c) 2026. The Authors. FAU - Mokose, Nonie M AU - Mokose NM AUID- ORCID: 0009-0009-8300-0869 AD - Department of Sustainable Food Systems and Development, Faculty of Natural and Agricultural Sciences, University of the Free State, Bloemfontein, South Africa. FAU - Swanepoel, Jan W AU - Swanepoel JW AUID- ORCID: 0000-0002-0812-2657 AD - Department of Sustainable Food Systems and Development, Faculty of Natural and Agricultural Sciences, University of the Free State, Bloemfontein, South Africa. FAU - Oldewage-Theron, Wilna AU - Oldewage-Theron W AUID- ORCID: 0000-0001-8975-5693 AD - Department of Sustainable Food Systems and Development, Faculty of Natural and Agricultural Sciences, University of the Free State, Bloemfontein, South Africa. LA - eng PT - Journal Article DEP - 20260526 PL - South Africa TA - Health SA JT - Health SA = SA Gesondheid JID - 101213385 PMC - PMC13243840 OTO - NOTNLM OT - South Africa OT - Urban health OT - adolescent obesity OT - central adiposity OT - overweight OT - socioeconomic status COIS- The authors declare that they have no financial or personal relationships that may have inappropriately influenced them in writing this article. EDAT- 2026/06/10 06:52 MHDA- 2026/06/10 06:53 PMCR- 2026/05/26 CRDT- 2026/06/10 04:45 PHST- 2025/11/11 00:00 [received] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/06/10 06:53 [medline] PHST- 2026/06/10 06:52 [pubmed] PHST- 2026/06/10 04:45 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - HSAG-31-3328 [pii] AID - 10.4102/hsag.v31i0.3328 [doi] PST - epublish SO - Health SA. 2026 May 26;31:3328. doi: 10.4102/hsag.v31i0.3328. eCollection 2026. PMID- 42265711 OWN - NLM STAT- MEDLINE DCOM- 20260814 LR - 20260816 IS - 1471-2482 (Electronic) IS - 1471-2482 (Linking) VI - 26 IP - 1 DP - 2026 Jun 10 TI - Development and validation of a preoperative nomogram for predicting postoperative high drainage output after robot-assisted Roux-en-Y hepaticojejunostomy for children with choledochal cysts: based on cyst diameter, age, and other indicators. LID - 10.1186/s12893-026-03912-1 [doi] LID - 543 AB - BACKGROUND: Robot-assisted Roux-en-Y hepaticojejunostomy (RYHJ) is the standard treatment for choledochal cysts (CDC). Routine abdominal drainage is typically placed, but no reliable preoperative tool exists to identify patients at risk of high drainage output (>/= 2 mL.kg(-)(1).d(-)(1)), limiting early drain removal or selective omission under close monitoring. This study aimed to develop and validate an intuitive preoperative nomogram using readily available clinical indicators (e.g., cyst diameter, age) to predict high-drainage risk after robot-assisted RYHJ and support individualized drainage management. METHODS: This single-center retrospective cohort study enrolled 129 children with CDC who underwent da Vinci robot-assisted RYHJ. Based on weight-adjusted daily drain output, patients were divided into low-drainage (< 2 mL.kg(-)(1).d(-)(1), n = 30) and high-drainage (>/= 2 mL.kg(-)(1).d(-)(1), n = 99) groups. Potential predictors were identified via univariate and multivariate logistic regression and incorporated into a nomogram. Model performance was assessed using the area under the receiver operating characteristic curve (AUC) and calibration plots. RESULTS: Multivariate analysis identified younger age as an independent predictor of high drainage output (OR = 0.983, 95% CI: 0.972-0.994), and larger cyst diameter as a potential predictor showing a trend toward association (OR = 1.321, 95% CI: 0.979-1.783). The final nomogram, incorporating cyst diameter, age, body mass index (BMI), hemoglobin (HGB), and globulin (GLB), showed good discrimination (AUC = 0.753) and calibration. The optimal risk threshold was 79.88%, yielding a specificity of 75.9%, and, using an optimal threshold, identifies low-risk patients suitable for early drain removal protocols to guide individualized drainage management. CONCLUSION: We have developed and validated a nomogram model based on "cyst diameter + age" (supplemented by BMI, HGB, and GLB) that enables noninvasive, precise assessment of high-drainage risk following robot-assisted RYHJ. Notably, the model identifies a low-risk subset-older children with smaller cysts-for whom early drain removal (e.g., within 24-48 h) is safe, and in whom selective drain omission could be prospectively evaluated under rigorous monitoring. This risk-stratified approach has the potential to reduce drain-related complications and optimize ERAS pathways following robot-assisted RYHJ. As this is an internal validation only, external validation in independent cohorts is warranted before clinical implementation. CI - (c) 2026. The Author(s). FAU - Zhang, Jing AU - Zhang J AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - You, Tao AU - You T AD - Medical Department, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, 430070, China. FAU - Qin, Xinke AU - Qin X AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - Liang, Chong AU - Liang C AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - Zhu, Zhenchuang AU - Zhu Z AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - Liu, Xin AU - Liu X AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - Ji, Siqi AU - Ji S AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - He, Xiaoqiong AU - He X AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - Duan, Xufei AU - Duan X AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - Yan, Xueqiang AU - Yan X AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. yanxueqiang1@163.com. LA - eng GR - 2025FEYJS005/the Laboratory of Hepatobiliary and Pancreatic Diseases in Children/ PT - Journal Article PT - Validation Study DEP - 20260610 PL - England TA - BMC Surg JT - BMC surgery JID - 100968567 SB - IM MH - Humans MH - *Nomograms MH - *Choledochal Cyst/surgery/pathology MH - Retrospective Studies MH - *Drainage MH - Infant MH - Female MH - *Anastomosis, Roux-en-Y/methods MH - Male MH - Child, Preschool MH - Child MH - *Robotic Surgical Procedures MH - *Postoperative Complications/etiology MH - *Jejunostomy/methods MH - Age Factors PMC - PMC13474786 OTO - NOTNLM OT - Choledochal cyst (CDC) OT - Enhanced recovery after surgery (ERAS) OT - High drainage output OT - Nomogram OT - Pediatric surgery OT - Robot-assisted Roux-en-Y hepaticojejunostomy (RYHJ) COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Wuhan Children's Hospital of Huazhong University of Science and Technology (Approval No. 2024R030-E01). Owing to the retrospective design of the study, the need for informed consent was waived. Owing to the retrospective design of the study, the need for informed consent was waived by the ethics committee of Wuhan Children's Hospital of Huazhong University of Science and Technology. The study was conducted according to the principles of the Declaration of Helsinki. Consent for publication: Not Applicable. This is a retrospective study. Competing interests: The authors declare no competing interests. EDAT- 2026/06/10 06:54 MHDA- 2026/08/14 05:38 PMCR- 2026/06/10 CRDT- 2026/06/10 00:10 PHST- 2025/11/17 00:00 [received] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/08/14 05:38 [medline] PHST- 2026/06/10 06:54 [pubmed] PHST- 2026/06/10 00:10 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.1186/s12893-026-03912-1 [pii] AID - 3912 [pii] AID - 10.1186/s12893-026-03912-1 [doi] PST - epublish SO - BMC Surg. 2026 Jun 10;26(1):543. doi: 10.1186/s12893-026-03912-1. PMID- 42264793 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260612 IS - 1532-9283 (Electronic) IS - 1360-8592 (Linking) VI - 47 DP - 2026 Jul TI - Kinetic-functional assessment of the adolescent idiopathic scoliosis: a cohort study. PG - 199-204 LID - S1360-8592(26)00051-3 [pii] LID - 10.1016/j.jbmt.2026.03.036 [doi] AB - INTRODUCTION: It is estimated that 1 to 3% of the world's population is diagnosed with idiopathic scoliosis, with a higher prevalence in females and a higher index of curves in the right thoracic region. Diagnosis and clinical follow-up are based on radiographic analysis and measurement of the Cobb angle, which is considered the gold standard for classifying scoliotic severity. OBJECTIVE: This study investigated the applicability and feasibility of the kinetic-functional examination in patients with adolescent idiopathic scoliosis, considering the main functional tests described in the literature. METHODS: It was a cross-sectional, quantitative cohort study (CAAE xxxxxxxxxxxxxxxxx) involving individuals of both sexes, aged between 10 and 14 years, who had a diagnosis of idiopathic scoliosis of the adolescent confirmed by radiographic examination (Cobb angle between 10 degrees and 50 degrees ). Statistical significance was set p < 0.05. RESULTS: A total of 157 individuals participated in the study, 77.7% were female and 57.9% were considered underweight according to body mass index. Regarding the degree of severity of the curve, 61.8% of the adolescents had a moderate scoliotic curve. A trend towards a reduction in spine flexibility was observed as the severity of the curvature increased, especially in mild and moderate curves, while the strength tests showed negative values, with no marked differences between the severity groups. CONCLUSION: The standardized application of functional tests ensures reliability and reproducibility of the results, and ensures the patient's performance, reducing biases, favoring clinical validity and assisting in the accurate identification of functional deficits. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Silva, Darlan Gonzaga da AU - Silva DGD AD - State University of Bahia (UNEB), Salvador, BA, Brazil. Electronic address: darlagfisio@gmail.com. FAU - Nascimento, Lara Galvao AU - Nascimento LG AD - Scoliosis Rehabilitation Clinical Center, Bahia, BA, Brazil. Electronic address: laragalvao26@gmail.com. FAU - da Silva, Beatriz Cerqueira AU - da Silva BC AD - Scoliosis Rehabilitation Clinical Center, Bahia, BA, Brazil. Electronic address: beatrizcerqueira.fisio@gmail.com. FAU - Andrade, Rodrigo Mantelatto AU - Andrade RM AD - Scoliosis Rehabilitation Clinical Center, Sao Paulo, SP, Brazil. Electronic address: rodrigoandradefisioterapia@gmail.com. FAU - Paineiras-Domingos, Laisa Liane AU - Paineiras-Domingos LL AD - Postgraduate Program in Medicine and Health, Faculty of Medicine of Bahia, Federal University of Bahia (UFBA), Salvador, BA, Brazil. Electronic address: laisa.liane@ufba.br. FAU - Lessa, Paulo Itamar Ferraz AU - Lessa PIF AD - State University of Bahia (UNEB), Salvador, BA, Brazil; Scoliosis Rehabilitation Clinical Center, Bahia, BA, Brazil. Electronic address: plessa@uneb.br. LA - eng PT - Journal Article DEP - 20260401 PL - United States TA - J Bodyw Mov Ther JT - Journal of bodywork and movement therapies JID - 9700068 SB - IM MH - Humans MH - *Scoliosis/physiopathology/diagnosis MH - Female MH - Adolescent MH - Cross-Sectional Studies MH - Child MH - Male MH - Cohort Studies MH - Range of Motion, Articular/physiology MH - Severity of Illness Index MH - Muscle Strength/physiology MH - Spine/physiopathology MH - Body Mass Index OTO - NOTNLM OT - Adolescent idiopathic scoliosis OT - Flexibility OT - Functional tests OT - Mobility OT - Muscle strength COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/10 06:52 MHDA- 2026/06/12 18:40 CRDT- 2026/06/09 21:02 PHST- 2026/02/24 00:00 [received] PHST- 2026/03/30 00:00 [revised] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/06/12 18:40 [medline] PHST- 2026/06/10 06:52 [pubmed] PHST- 2026/06/09 21:02 [entrez] AID - S1360-8592(26)00051-3 [pii] AID - 10.1016/j.jbmt.2026.03.036 [doi] PST - ppublish SO - J Bodyw Mov Ther. 2026 Jul;47:199-204. doi: 10.1016/j.jbmt.2026.03.036. Epub 2026 Apr 1. PMID- 42263736 OWN - NLM STAT- MEDLINE DCOM- 20260918 LR - 20260918 IS - 1938-2480 (Electronic) IS - 1538-8506 (Linking) VI - 39 IP - 12 DP - 2026 Oct TI - Comparison of Long-Term Tunnel Widening in Anterior Cruciate Ligament Reconstruction Using Allograft and Hamstring Autograft: More Than 10 Years' Mean Follow-Up. PG - 654-661 LID - 10.1055/a-2886-8283 [doi] AB - Bone tunnel widening following anterior cruciate ligament reconstruction (ACLR) is a well-recognized radiological phenomenon with multifactorial etiology. While concerns have been raised regarding potentially greater tunnel enlargement with allografts due to immune-mediated responses, evidence remains inconsistent. This study compared long-term femoral and tibial tunnel widening between hamstring autograft and allograft reconstruction at a mean follow-up exceeding 10 years. A retrospective analysis was conducted on 60 patients who underwent primary ACLR between 2011 and 2016 by a single surgeon. Group I consisted of 29 patients receiving soft tissue allografts (Achilles, tibialis anterior, or peroneus longus tendons), while Group II included 31 patients with four-strand hamstring autografts. All procedures utilized identical fixation: adjustable-loop suspension device (femur) and bioabsorbable interference screw with tibial staple. Patients with previous knee surgery, re-rupture, clinical graft failure, concomitant ligament procedures, or significant chondral lesions were excluded. Computed tomography scans at final follow-up (mean: 10.7 years) were analyzed using standardized oblique reformatted sections perpendicular to tunnel axes. Six measurements per tunnel (three levels x two planes) were averaged. Tunnel widening was expressed as absolute change (Deltamm) and percentage relative to intraoperative drill bit diameter. Two blinded orthopedic surgeons performed independent measurements. Statistical analysis included Mann-Whitney U test, analysis of covariance adjusted for body mass index (BMI) and follow-up duration, categorical threshold analysis, and correlation analysis with Bonferroni correction. No significant differences were observed between groups for tibial widening (allograft 2.07 +/- 1.75 mm vs. autograft 2.31 +/- 1.72 mm, p = 0.500) or femoral widening (1.73 +/- 1.48 mm vs. 2.30 +/- 1.63 mm, p = 0.157). After adjustment for BMI and follow-up duration, between-group differences remained nonsignificant (all adjusted p > 0.0125 after Bonferroni correction). Categorical distribution across predefined thresholds showed similar patterns. Initial tunnel diameter inversely correlated with tibial percentage widening (r =-0.373, p = 0.003). Interobserver reliability was excellent (intraclass correlation coefficient: 0.89-0.92). At long-term follow-up, allograft and hamstring autograft demonstrated comparable tunnel widening patterns, suggesting graft selection should prioritize clinical factors beyond tunnel enlargement concerns. CI - Thieme. All rights reserved. FAU - Ipek, Enver AU - Ipek E AUID- ORCID: 0000-0001-6205-1207 AD - Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Department of Orthopedics and Traumatology, Turkey. FAU - Altuntas, Yusuf AU - Altuntas Y AD - Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Department of Orthopedics and Traumatology, Turkey. FAU - Balkanli, Bahadir AU - Balkanli B AD - Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Department of Orthopedics and Traumatology, Turkey. FAU - Yuksel, Mehmet Alp AU - Yuksel MA AD - Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Department of Orthopedics and Traumatology, Turkey. FAU - Akbas, Harun AU - Akbas H AD - Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Department of Orthopedics and Traumatology, Turkey. FAU - Eren, Osman Tugrul AU - Eren OT AD - Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Department of Orthopedics and Traumatology, Turkey. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260609 PL - Germany TA - J Knee Surg JT - The journal of knee surgery JID - 101137599 SB - IM MH - Humans MH - Retrospective Studies MH - *Anterior Cruciate Ligament Reconstruction/methods MH - Female MH - Follow-Up Studies MH - *Hamstring Tendons/transplantation MH - Adult MH - Allografts MH - Male MH - Autografts MH - *Tibia/surgery/diagnostic imaging MH - Transplantation, Autologous MH - *Femur/surgery/diagnostic imaging MH - *Anterior Cruciate Ligament Injuries/surgery MH - Young Adult MH - Tomography, X-Ray Computed MH - Transplantation, Homologous MH - Adolescent COIS- The authors declare that they have no conflict of interest. EDAT- 2026/06/10 06:52 MHDA- 2026/09/18 23:36 CRDT- 2026/06/09 19:03 PHST- 2026/09/18 23:36 [medline] PHST- 2026/06/10 06:52 [pubmed] PHST- 2026/06/09 19:03 [entrez] AID - 10.1055/a-2886-8283 [doi] PST - ppublish SO - J Knee Surg. 2026 Oct;39(12):654-661. doi: 10.1055/a-2886-8283. Epub 2026 Jun 9. PMID- 42262874 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20260922 IS - 1555-905X (Electronic) IS - 1555-9041 (Print) IS - 1555-9041 (Linking) VI - 21 IP - 9 DP - 2026 Sep 1 TI - Evaluation of the Association between Age, Sex, and d -Amino Acid-Based Estimation of GFR. PG - 1545-1553 LID - 10.2215/CJN.0000001108 [doi] AB - KEY POINTS: Blood d -serine and d -asparagine reflect GFR, reportedly with stable kinetics minimally influenced by age and tubular transport. d -Amino acid-based eGFR minimizes age and sex biases, a distinct advantage over conventional models. d -Amino acid-based eGFR holds broad clinical potential across all ages and populations. BACKGROUND: eGFR is challenging because of its dependence on age and body composition, especially in pediatric and elderly populations. Recently, d -serine and d -asparagine, rare amino acid enantiomers, have been identified as GFR biomarkers characterized by their ideal kidney clearance and minimal impacts of body size. We investigated the impact of age and sex on GFR estimation using these d -amino acids. METHODS: We analyzed data from a cross-sectional observational cohort: 366 adult Japanese living kidney transplant donors and recipients. Using a dataset of 244 patients, we developed GFR estimation formulae on the basis of blood levels of d -serine and d -asparagine using linear regression analyses and validated the formulas' performance in 122 patients. RESULTS: The d -amino acid - based equation was established as 60.4x d -Ser -0.450 x d -Asn -0.304 x0.916 (if female), in which age did not significantly improve model performance and the impact of sex was minor. The performance of the established equations was equivalent to that of creatinine-based equations: bias (absolute difference), 9.1 (8.0-11.2); precision (interquartile range of bias), 11.1 (8.8-14.2); and accuracy (ratios of 30% different from measured GFR [P 30 ]), 0.82 (0.73-0.89). CONCLUSIONS: d -Amino acid-based estimation of GFR exhibits minimal empirical association with age and sex, offering a distinct advantage over models dependent on these demographic variables. This stability may support its broad clinical utility as a reliable diagnostic tool across all age groups and diverse populations. CI - Copyright (c) 2026 by the American Society of Nephrology. FAU - Fukae, Shota AU - Fukae S AD - Department of Urology, The University of Osaka Graduate School of Medicine, Osaka, Japan. FAU - Sakai, Shinsuke AU - Sakai S AUID- ORCID: 0009-0004-3295-0390 AD - Department of Nephrology, The University of Osaka Graduate School of Medicine, Osaka, Japan. FAU - Tanaka, Ryo AU - Tanaka R AUID- ORCID: 0000-0003-1144-7820 AD - Department of Urology, The University of Osaka Graduate School of Medicine, Osaka, Japan. FAU - Taniguchi, Ayumu AU - Taniguchi A AUID- ORCID: 0000-0001-7869-1786 AD - Department of Urology, Juntendo University Urayasu Hospital, Chiba, Japan. FAU - Kawamura, Masataka AU - Kawamura M AUID- ORCID: 0000-0003-1454-0588 AD - Department of Urology, The University of Osaka Graduate School of Medicine, Osaka, Japan. FAU - Kimura-Ohba, Shihoko AU - Kimura-Ohba S AD - Department of Virology, The University of Osaka Graduate School of Medicine, Osaka, Japan. FAU - Nakazawa, Shigeaki AU - Nakazawa S AUID- ORCID: 0000-0001-5857-3483 AD - Department of Urology, The University of Osaka Graduate School of Medicine, Osaka, Japan. FAU - Horio, Masaru AU - Horio M AD - Department of Nephrology, Kansai Medical Hospital, Osaka, Japan. FAU - Takahara, Shiro AU - Takahara S AD - Department of Renal Transplantation, Kansai Medical Clinic, Osaka, Japan. FAU - Imamura, Ryoichi AU - Imamura R AUID- ORCID: 0000-0002-8782-9852 AD - Department of Urology, Nagasaki University Graduate School of Medicine, Nagasaki, Japan. FAU - Yamada, Muneharu AU - Yamada M AUID- ORCID: 0000-0003-0483-0012 AD - Department of Nephrology and Blood Purification, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan. FAU - Oda, Takashi AU - Oda T AUID- ORCID: 0000-0002-6131-7752 AD - Department of Nephrology and Blood Purification, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan. FAU - Konno, Osamu AU - Konno O AUID- ORCID: 0000-0001-7706-0616 AD - Department of Kidney Transplantation Surgery, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan. FAU - Iwamoto, Hitoshi AU - Iwamoto H AD - Department of Kidney Transplantation Surgery, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan. FAU - Isaka, Yoshitaka AU - Isaka Y AUID- ORCID: 0000-0002-0820-7167 AD - Department of Nephrology, The University of Osaka Graduate School of Medicine, Osaka, Japan. FAU - Mizui, Masayuki AU - Mizui M AUID- ORCID: 0000-0003-2543-8108 AD - Department of Nephrology, The University of Osaka Graduate School of Medicine, Osaka, Japan. FAU - Nonomura, Norio AU - Nonomura N AD - Department of Urology, The University of Osaka Graduate School of Medicine, Osaka, Japan. FAU - Kakuta, Yoichi AU - Kakuta Y AUID- ORCID: 0000-0001-5339-4312 AD - Department of Urology, The University of Osaka Graduate School of Medicine, Osaka, Japan. FAU - Kimura, Tomonori AU - Kimura T AUID- ORCID: 0000-0001-8186-094 AD - Department of Nephrology, The University of Osaka Graduate School of Medicine, Osaka, Japan. AD - Department of Nephrology, Kansai Medical Hospital, Osaka, Japan. AD - Department of Renal Transplantation, Kansai Medical Clinic, Osaka, Japan. LA - eng GR - 21H02935/Japan Society for the Promotion of Science/ GR - NA/Manpei Suzuki Diabetes Foundation/ PT - Journal Article PT - Observational Study DEP - 20260609 PL - United States TA - Clin J Am Soc Nephrol JT - Clinical journal of the American Society of Nephrology : CJASN JID - 101271570 RN - 452VLY9402 (Serine) RN - 7006-34-0 (Asparagine) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Glomerular Filtration Rate MH - Female MH - Male MH - Age Factors MH - Cross-Sectional Studies MH - Sex Factors MH - Kidney Transplantation MH - Middle Aged MH - *Serine/blood MH - Adult MH - *Asparagine/blood MH - Aged MH - Biomarkers/blood MH - Linear Models PMC - PMC13549483 OTO - NOTNLM OT - CKD OT - transplantation COIS- Disclosure forms, as provided by each author, are available with the online version of the article at http://links.lww.com/CJN/C758. EDAT- 2026/06/09 18:44 MHDA- 2026/09/10 17:42 PMCR- 2026/09/01 CRDT- 2026/06/09 12:03 PHST- 2026/01/28 00:00 [received] PHST- 2026/06/04 00:00 [accepted] PHST- 2026/09/10 17:42 [medline] PHST- 2026/06/09 18:44 [pubmed] PHST- 2026/06/09 12:03 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - 01277230-990000000-00942 [pii] AID - CJASN-2026-000141 [pii] AID - 10.2215/CJN.0000001108 [doi] PST - ppublish SO - Clin J Am Soc Nephrol. 2026 Sep 1;21(9):1545-1553. doi: 10.2215/CJN.0000001108. Epub 2026 Jun 9. PMID- 42260933 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260624 IS - 1365-2214 (Electronic) IS - 0305-1862 (Linking) VI - 52 IP - 4 DP - 2026 Jul TI - Associations of Parental KAP Regarding Children's Screen Exposure, Home Nurture Environment, Parent-Child Screen and Parent-Child Interaction in Children Aged 2-3 Years: A Structural Equation Modelling. PG - e70300 LID - 10.1111/cch.70300 [doi] AB - BACKGROUND: Early childhood development is profoundly influenced by parent-child interaction yet the impact of parental knowledge, attitude and practice (KAP) regarding screen exposure and home environment on these dynamics remains underexplored. This study investigates the associations between parental KAP on screen exposure, home nurture environment and parent-child interaction quality in children aged 2-3 years, addressing a critical gap in understanding how digital media habits shape early developmental contexts. METHODS: A cross-sectional study was conducted with 252 parents of children aged 2-3 years. Data were collected through validated questionnaires assessing parental KAP on screen exposure, parent-Child screen, home nurture environment and parent-child interaction quality. Structural equation modelling was employed to analyze direct and indirect pathways between variables. RESULTS: Parent-child screen exhibited a significant positive direct effect on parent-child interaction (beta = 0.540, p < 0.01). The child home nurture environment had a significant positive direct effect on parent-child interaction (beta = 0.366, p < 0.01) and also exerted an indirect positive effect on parent-child interaction through parent-child screen (beta = 0.320, p < 0.01). Parental KAP regarding children's screen exposure exerted an indirect positive effect on parent-child interaction (beta = 0.440, p < 0.01) through two pathways: one through the single mediating effect of child home nurture environment, and the other through the chain mediating effect from the child home nurture environment to parent-child screen. CONCLUSIONS: Supportive home environment and proactive parental engagement are pivotal in fostering positive parent-child interaction amidst rising screen exposure. Interventions targeting KAP improvement and balanced screen-use practices could enhance early childhood development. This study underscores the need for policy and educational programs to empower parents in creating nurturing, screen-smart home environment for early childhood. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Zhang, Lijuan AU - Zhang L AUID- ORCID: 0000-0003-0799-1815 AD - Nursing Department, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. AD - Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. FAU - Shi, Tingting AU - Shi T AD - College of Nursing, Honghe College of Health Professions, Mengzi, Yunnan, China. FAU - Fu, Bing AU - Fu B AUID- ORCID: 0009-0007-5872-5740 AD - Nursing Department, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. AD - Department of Gynecology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. LA - eng GR - 2023JJ40915/Natural Science Foundation of Hunan Province/ PT - Journal Article PL - England TA - Child Care Health Dev JT - Child: care, health and development JID - 7602632 SB - IM MH - Humans MH - *Parent-Child Relations MH - Child, Preschool MH - Female MH - Cross-Sectional Studies MH - Male MH - *Parents/psychology/education MH - *Screen Time MH - Media Exposure MH - *Parenting/psychology MH - Health Knowledge, Attitudes, Practice MH - Home Environment MH - Child Development MH - Adult MH - Digital Media MH - Television/statistics & numerical data MH - Surveys and Questionnaires OTO - NOTNLM OT - family nurturing environment OT - home nurture environment OT - knowledge- attitude-and practice OT - parent-child interaction OT - screen exposure EDAT- 2026/06/09 06:35 MHDA- 2026/06/13 06:37 CRDT- 2026/06/09 01:22 PHST- 2026/05/20 00:00 [revised] PHST- 2025/11/24 00:00 [received] PHST- 2026/05/23 00:00 [accepted] PHST- 2026/06/13 06:37 [medline] PHST- 2026/06/09 06:35 [pubmed] PHST- 2026/06/09 01:22 [entrez] AID - 10.1111/cch.70300 [doi] PST - ppublish SO - Child Care Health Dev. 2026 Jul;52(4):e70300. doi: 10.1111/cch.70300. PMID- 42260866 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 23 DP - 2026 Jun 5 TI - Causal link between maternal PCOS and fetal/neonatal hemorrhagic and hematological disorders: A 2-sample MR study. PG - e49143 LID - 10.1097/MD.0000000000049143 [doi] LID - e49143 AB - Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age, affecting approximately 5 to 13% of this population. Beyond its reproductive implications, PCOS is frequently accompanied by metabolic and psychological disturbances, including obesity, insulin resistance, diabetes, and depressive symptoms. Increasing evidence suggests that genetic liability to PCOS may be associated with adverse pregnancy and neonatal outcomes; however, whether these associations reflect causal relationships remains uncertain. In this study, we conducted a 2-sample Mendelian randomization (MR) analysis to evaluate the potential association between genetically predicted PCOS liability and fetal or neonatal hemorrhagic and hematologic disorders. Genetic instruments for PCOS were obtained from large-scale genome-wide association studies, and outcome data were derived from the FinnGen consortium. The inverse variance weighted method served as the primary estimator, complemented by MR-Egger regression and weighted median approaches, along with multiple sensitivity analyses to assess heterogeneity and horizontal pleiotropy. The inverse variance weighted analysis indicated a statistically significant association between genetically predicted PCOS and an increased risk of fetal or neonatal hemorrhagic and hematologic disorders (odds ratio = 1.80; 95% confidence interval, 1.11-2.91). Although complementary MR methods did not reach statistical significance, the direction of effect was consistent across estimators, and no evidence of heterogeneity or directional pleiotropy was detected. Taken together, these findings provide genetic epidemiological evidence supporting a potential causal effect between genetic liability to PCOS and adverse fetal or neonatal hemorrhagic and hematologic disorders, warranting further validation through prospective clinical and mechanistic studies. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Yang, Chunyan AU - Yang C AD - Hebei Medical University, Shijiazhuang, Hebei, China. AD - Department of Obstetrics and Gynecology, Xingtai People's Hospital, Xingtai, Hebei, China. FAU - Song, Wenhui AU - Song W AD - Institute of Reproductive Medicine of Shijiazhuang, The Fourth Hospital of Shijiazhuang, Gynecology and Obstetrics Hospital Affiliated to Hebei Medical University, Shijiazhuang, Hebei, China. FAU - Lu, Kaosheng AU - Lu K AD - Hebei Medical University, Shijiazhuang, Hebei, China. AD - Department of Orthopaedic Surgery, The General Hospital of Jizhong Energy Xingtai Mining Group, Xingtai, Hebei, China. FAU - Dang, Wei AU - Dang W AD - Medical Research Center, Xingtai Medical College, Xingtai, Hebei, China. FAU - Feng, Jinhui AU - Feng J AD - Department of Obstetrics and Gynecology, Xingtai People's Hospital, Xingtai, Hebei, China. FAU - Li, Yalin AU - Li Y AD - Department of Obstetrics and Gynecology, Xingtai People's Hospital, Xingtai, Hebei, China. FAU - Li, Ling AU - Li L AD - Department of Neonatology, Xingtai People's Hospital, Xingtai, Hebei, China. FAU - Zhang, Fengchao AU - Zhang F AD - Department of Emergency Medicine, Xingtai People's Hospital, Xingtai, Hebei, China. FAU - Liu, Lingjuan AU - Liu L AD - Department of Obstetrics and Gynecology, The Ninth Hospital of Xingtail, Xingtai, Hebei, China. FAU - Wu, Xiaohua AU - Wu X AUID- ORCID: 0000-0002-5661-5085 AD - Hebei Medical University, Shijiazhuang, Hebei, China. AD - Institute of Reproductive Medicine of Shijiazhuang, The Fourth Hospital of Shijiazhuang, Gynecology and Obstetrics Hospital Affiliated to Hebei Medical University, Shijiazhuang, Hebei, China. LA - eng GR - H2021106030/Natural Science Foundation of Hebei Province in China/ GR - 2020ZC156/Self-financing project of Xingtai Key Research and Development Program/ GR - 20221876/Health Commission Research Fund Project of Hebei Province in China/ PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Female MH - Humans MH - Pregnancy MH - *Polycystic Ovary Syndrome/genetics/complications MH - Mendelian Randomization Analysis MH - *Hematologic Diseases/genetics/epidemiology/etiology MH - Genome-Wide Association Study MH - Infant, Newborn MH - Genetic Predisposition to Disease MH - *Hemorrhagic Disorders/genetics MH - *Fetal Diseases/genetics/epidemiology MH - Polymorphism, Single Nucleotide PMC - PMC13246132 OTO - NOTNLM OT - Fetal and neonatal hematologic disorders OT - Genetic epidemiology OT - Genetic liability OT - Mendelian randomization OT - Perinatal outcomes OT - Placental dysfunction OT - Polycystic ovary syndrome COIS- The authors have no conflicts of interest to disclose. EDAT- 2026/06/09 06:36 MHDA- 2026/06/13 06:39 PMCR- 2026/06/05 CRDT- 2026/06/09 01:01 PHST- 2025/10/23 00:00 [received] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/06/13 06:39 [medline] PHST- 2026/06/09 06:36 [pubmed] PHST- 2026/06/09 01:01 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - 00005792-202606050-00075 [pii] AID - MD-D-25-14050 [pii] AID - 10.1097/MD.0000000000049143 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Jun 5;105(23):e49143. doi: 10.1097/MD.0000000000049143. PMID- 42260192 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260726 IS - 1433-7339 (Electronic) IS - 0941-4355 (Print) IS - 0941-4355 (Linking) VI - 34 IP - 7 DP - 2026 Jun 9 TI - Food insecurity, dietary quality, and cardiovascular risk among early childhood cancer survivors. LID - 10.1007/s00520-026-10870-0 [doi] LID - 631 AB - PURPOSE: Childhood cancer survivors (CCS) have 7-times higher risk of cardiovascular mortality than the general population, highlighting the importance of addressing modifiable cardiovascular risk factors. In this study, we aimed to quantify the prevalence of food and nutrition insecurity-known cardiovascular risk factors-among a single-center cohort of early CCS, and explore these factors as drivers of adverse CCS dietary and cardiovascular outcomes. METHODS: Children aged < 18 years and < 1 year off-therapy were enrolled at a quaternary pediatric cancer center. Parents/guardians of participants completed an electronic survey including validated measures of food and nutrition insecurity and dietary quality, measured with the Rapid Prime Dietary Quality Score Screener. Therapeutic (anthracycline or radiation exposure) and clinical cardiovascular risk factors (overweight/obesity, elevated blood pressure, dyslipidemia, or prediabetes/diabetes) were abstracted from the medical record. We descriptively summarized food insecurity prevalence, dietary quality, and cardiovascular risk and examined associations using univariate and multivariable logistic and linear regression analyses. RESULTS: Among 115 enrolled participants with a mean age 8.3 years and mean 5.3 months from end of therapy, 27% (n = 31) lived in food-insecure households and 33% (n = 38) had nutrition insecurity. Mean dietary quality was 27.6/52 (SD 5.3). Participants in food-insecure households experienced significantly lower dietary quality compared to food-secure households on univariate analysis (25.9 vs 28.2, p = 0.04); in multivariable analyses, this difference was not significant. Among the sub-cohort with available medical record abstraction data (n = 97), 84% (n = 81) had >/= 1 cardiovascular risk factor and 39% had >/= 2 risk factors. CONCLUSIONS: One in four early CCS lives with food insecurity. These children concurrently experience multiple cardiovascular risk factors and suboptimal dietary quality. Interventions targeting food and nutrition insecurity and other modifiable cardiovascular risk factors have potential to mitigate late effects and advance equity in survivorship outcomes. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Aziz-Bose, Rahela AU - Aziz-Bose R AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. rahela_aziz-bose@dfci.harvard.edu. AD - Harvard Medical School, Boston, MA, USA. rahela_aziz-bose@dfci.harvard.edu. AD - Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. rahela_aziz-bose@dfci.harvard.edu. FAU - Paul, Morgan A AU - Paul MA AD - Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. FAU - Lokko, Lucille AU - Lokko L AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. FAU - Jones, Emily AU - Jones E AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. FAU - Meng, Julie AU - Meng J AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. FAU - Fry, Callie AU - Fry C AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. AD - Harvard Medical School, Boston, MA, USA. FAU - Kelly, Colleen A AU - Kelly CA AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. AD - Harvard Medical School, Boston, MA, USA. AD - Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. FAU - Umaretiya, Puja J AU - Umaretiya PJ AD - Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. FAU - Duhaney, Leanne AU - Duhaney L AD - Division of Cardiology, Boston Children's Hospital, Boston, MA, USA. FAU - Kenney, Lisa B AU - Kenney LB AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. AD - Harvard Medical School, Boston, MA, USA. AD - Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. FAU - Zhang, Fang Fang AU - Zhang FF AD - Friedman School of Nutrition and Public Policy, Tufts University, Boston, MA, USA. FAU - Bona, Kira AU - Bona K AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. AD - Harvard Medical School, Boston, MA, USA. AD - Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. LA - eng GR - T32 CA136432/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20260609 PL - Germany TA - Support Care Cancer JT - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer JID - 9302957 SB - IM MH - Humans MH - *Food Insecurity MH - Male MH - Female MH - Child MH - Heart Disease Risk Factors MH - *Cancer Survivors/statistics & numerical data MH - *Diet/standards/statistics & numerical data MH - *Cardiovascular Diseases/epidemiology/etiology MH - Child, Preschool MH - *Neoplasms/therapy MH - Infant MH - Cohort Studies MH - Adolescent MH - Risk Factors MH - Prevalence PMC - PMC13384394 MID - NIHMS2190528 OTO - NOTNLM OT - Cardiovascular disease OT - Childhood cancer survivors OT - Food insecurity OT - Nutrition insecurity OT - Social determinants of health COIS- Declarations. Ethics Approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Institutional Review Board of Dana-Farber Cancer Institute (protocol DFCI 23-398). Consent to participate: Informed consent was obtained from all study participants, with a waiver of written documentation of informed consent. Consent to publish: N/A Role of the Funder: The funders did not play a role in the design of the study; the collection, analysis, and interpretation of the data; the writing of the manuscript; or the decision to submit the manuscript for publication. Competing interests: The authors declare no competing interests. EDAT- 2026/06/09 00:34 MHDA- 2026/06/13 06:39 PMCR- 2027/06/09 CRDT- 2026/06/08 23:33 PHST- 2026/03/27 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/06/13 06:39 [medline] PHST- 2026/06/09 00:34 [pubmed] PHST- 2026/06/08 23:33 [entrez] PHST- 2027/06/09 00:00 [pmc-release] AID - 10.1007/s00520-026-10870-0 [pii] AID - 10.1007/s00520-026-10870-0 [doi] PST - epublish SO - Support Care Cancer. 2026 Jun 9;34(7):631. doi: 10.1007/s00520-026-10870-0. PMID- 42259763 OWN - NLM STAT- Publisher LR - 20260608 IS - 1558-688X (Electronic) IS - 0031-5125 (Linking) DP - 2026 Jun 8 TI - Do Individual and School Characteristics Influence the Siblings' Resemblance of Gross Motor Coordination Among Brazilian Youth? PG - 315125261457205 LID - 10.1177/00315125261457205 [doi] AB - ObjectivesThis study aimed to investigate the degree of siblings' resemblance in gross motor coordination (GMC), and to estimate the influence of individual and school context factors on siblings' resemblance in GMC among Brazilian children.MethodsThe sample comprised 626 siblings (5-15 years; 48.72% girls) from Lagoa do Carro, Brazil. GMC was assessed using the Korperkoordinationtest fur Kinder (KTK) battery. Body mass index, biological maturation, health- and performance-related physical fitness, and school characteristics (e.g., school s physical structure and policies and practices related to physical activity and sports) were also obtained. Intraclass correlations were calculated for each of the three sibling types: Brother-Brother (BB), Sister-Sister (SS), and Brother-Sister (BS). Multilevel modeling was performed using the Bayesian approach.ResultsIn general, sibling intraclass correlations varied between sibling types for all GMC tests. BB pairs had a higher resemblance in the moving sideways test, while SS pairs showed a higher resemblance in the walking backward and jumping sideways tests. BS pairs had a higher resemblance in the hopping for height test. For the GMC total score, BB and SS pairs had similar intraclass correlations. However, they showed a higher resemblance than BS pairs. Further, both individual and school characteristics influenced the magnitude of sibling resemblance.ConclusionIndividual and school characteristics are associated with different GMC traits and influence the magnitude of intrapair variance. FAU - Prazeres, Thaliane Mayara Pessoa Dos AU - Prazeres TMPD AUID- ORCID: 0000-0003-0640-2353 AD - Escola Superior de Educacao Fisica, Universidade de Pernambuco, Recife, Brasil. RINGGOLD: 117110 FAU - Henrique, Rafael Dos Santos AU - Henrique RDS AUID- ORCID: 0000-0003-3912-5559 AD - Departamento de Educacao Fisica, Universidade Federal de Pernambuco, Recife, Brasil. FAU - Luz, Leonardo Gomes de Oliveira AU - Luz LGO AD - Departamento de Educacao Fisica, Universidade Federal de Alagoas, Arapiraca, Brasil. FAU - Martins, Clarice Maria de Lucena AU - Martins CML AD - CIAFEL, Faculdade do Desporto, Universidade do Porto, Porto, Portugal. FAU - Albuquerque, Maicon Rodrigues AU - Albuquerque MR AUID- ORCID: 0000-0001-6021-8480 AD - Departamento de Esportes, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil. RINGGOLD: 28114 FAU - Ribeiro, Marcella Dantas AU - Ribeiro MD AD - Escola Superior de Educacao Fisica, Universidade de Pernambuco, Recife, Brasil. RINGGOLD: 117110 FAU - Sobral, Igor Rodrigues AU - Sobral IR AD - Departamento de Educacao Fisica, Universidade Federal de Pernambuco, Recife, Brasil. FAU - Olveira, Nayara de Souza AU - Olveira NS AD - Departamento de Educacao Fisica, Universidade Federal de Pernambuco, Recife, Brasil. FAU - Lira-Filho, Rostand de Souza AU - Lira-Filho RS AD - Departamento de Educacao Fisica, Universidade Federal de Pernambuco, Recife, Brasil. FAU - Moura-Dos-Santos, Marcos Andre AU - Moura-Dos-Santos MA AD - Escola Superior de Educacao Fisica, Universidade de Pernambuco, Recife, Brasil. RINGGOLD: 117110 LA - eng PT - Journal Article DEP - 20260608 PL - United States TA - Percept Mot Skills JT - Perceptual and motor skills JID - 0401131 SB - IM OTO - NOTNLM OT - child OT - motor competence OT - multilevel modeling OT - school OT - siblings EDAT- 2026/06/09 00:34 MHDA- 2026/06/09 00:34 CRDT- 2026/06/08 22:53 PHST- 2026/06/09 00:34 [medline] PHST- 2026/06/09 00:34 [pubmed] PHST- 2026/06/08 22:53 [entrez] AID - 10.1177/00315125261457205 [doi] PST - aheadofprint SO - Percept Mot Skills. 2026 Jun 8:315125261457205. doi: 10.1177/00315125261457205. PMID- 42259585 OWN - NLM STAT- MEDLINE DCOM- 20260609 LR - 20260624 IS - 1756-1833 (Electronic) IS - 0959-8138 (Linking) VI - 393 DP - 2026 Jun 8 TI - Advances in the management of ADHD in children and adolescents. PG - e082507 LID - 10.1136/bmj-2024-082507 [doi] AB - This review synthesizes evidence on managing attention deficit/hyperactivity disorder (ADHD) in children and adolescents, focusing on studies published between 2019 and 2025. Recent research supports a dimensional, pleiotropic model of ADHD characterized by heterogeneity, developmental fluctuation, and frequent comorbidity. ADHD is a chronic, fluctuating condition, underscoring the need for sustained and individualized care. Diagnostic strategies favor semi-structured interviews over rating scales, with neuroimaging or biological tests offering limited diagnostic utility. Neuropsychological testing situates symptoms within broader cognitive developmental profiles. Psychosocial interventions-particularly behavioral parent training, school focused interventions, and cognitive behavioral therapy-produce small but meaningful improvements in functioning, with outcomes strongly shaped by rater, expectancy, and context. Lifestyle interventions targeting physical activity and sleep show modest adjunctive benefits. Cognitive training does not generalize beyond trained tasks, and effects on neurofeedback are predominantly non-specific and contextual. Digital tools are expanding, but few are rigorously validated. Pharmacological treatment remains central, with stimulants showing robust short term efficacy and non-stimulants providing effective second line options. Advances in titration strategies, formulation design, and pharmacogenetics support movement towards precision oriented and personalized prescribing. Overall, the evidence supports a multimodal, pragmatic approach to care aligned with current international guidelines. CI - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. FAU - Robaey, Philippe AU - Robaey P AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada probaey@cheo.on.ca. AD - Department of Psychiatry, University of Ottawa, Ottawa, ON, Canada. FAU - Rogers, Maria A AU - Rogers MA AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada. AD - Department of Psychology, Carleton University, Ottawa, ON, Canada. FAU - Schachar, Russell J AU - Schachar RJ AD - Department of Psychiatry, University of Toronto, Toronto, ON, Canada. AD - Department of Psychiatry, The Hospital for Sick Children, Toronto, ON, Canada. LA - eng PT - Journal Article PT - Review DEP - 20260608 PL - England TA - BMJ JT - BMJ (Clinical research ed.) JID - 8900488 RN - 0 (Central Nervous System Stimulants) SB - IM MH - Adolescent MH - Child MH - Humans MH - *Attention Deficit Disorder with Hyperactivity/diagnosis/therapy MH - Central Nervous System Stimulants/therapeutic use MH - Cognitive Behavioral Therapy/methods MH - Cognitive Training COIS- Competing interests: We have read and understood the BMJ policy on declaration of interests and declare the following interests: none. EDAT- 2026/06/09 00:34 MHDA- 2026/06/10 06:53 CRDT- 2026/06/08 20:52 PHST- 2026/06/10 06:53 [medline] PHST- 2026/06/09 00:34 [pubmed] PHST- 2026/06/08 20:52 [entrez] AID - 10.1136/bmj-2024-082507 [doi] PST - epublish SO - BMJ. 2026 Jun 8;393:e082507. doi: 10.1136/bmj-2024-082507. PMID- 42259520 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2190-6009 (Electronic) IS - 2190-5991 (Print) IS - 2190-5991 (Linking) VI - 17 IP - 3 DP - 2026 Jun TI - Diagnostic Utility of Muscle Ultrasound for Sarcopenia in Prader-Willi Syndrome: A Cross-Sectional Study. PG - e70326 LID - 10.1002/jcsm.70326 [doi] LID - e70326 AB - BACKGROUND: Prader-Willi syndrome (PWS) is characterized by sarcopenic obesity; however, validated screening tools for muscle mass in clinical settings are lacking. This study aimed to evaluate the diagnostic utility of muscle ultrasound (US) for detecting low muscle mass in individuals with PWS. METHODS: This observational, cross-sectional study recruited 48 individuals with genetically confirmed PWS (International Classification of Diseases, 10th Revision Code Q87.1) from a specialized clinic (October 2022-June 2024). Appendicular skeletal muscle index (ASMI) via dual-energy x-ray absorptiometry (DXA) served as the primary outcome. Sarcopenia was defined based on Asian Working Group for Sarcopenia (AWGS) 2019 criteria. US predictors included muscle thickness (MT) of the rectus femoris (RF), vastus lateralis and gastrocnemius medialis (GM); pennation angle; and RF cross-sectional area (CSA). Analysis included Spearman's correlation (rho), multivariable linear regression (B) and receiver operating characteristic (ROC) curves. RESULTS: The cohort (n = 48; 47.9% women; median age 19.5 years, interquartile range [IQR] 12.3-26.8) had a 100% prevalence of obesity (median BMI 27.1 kg/m(2), IQR 22.2-31.4). All participants (100%) had a history of growth hormone treatment; 62.5% exhibited the deletion subtype. Low muscle mass was observed in 60.4% (n = 29), confirmed sarcopenia in 52.1% (n = 25) and severe sarcopenia (including low physical performance) in 20.8% (n = 10) participants. GM MT showed the strongest correlation with ASMI (rho = 0.689, p < 0.001, 95% confidence interval [CI] 0.50-0.81), followed by RF CSA (rho = 0.587, p < 0.001). Multivariable regression identified GM MT as a significant independent predictor of ASMI (B = 0.957, p = 0.011) after adjusting for BMI (B = 0.128, p < 0.001), age (B = 0.020, p = 0.044) and sex (B = -0.376, p = 0.029; R(2) = 0.67). ROC analysis for detecting low muscle mass yielded an area under the curve for GM MT of 0.759 (95% CI 0.616-0.901, p = 0.003), with an optimal cut-off of 1.69 cm (sensitivity 86.2%, specificity 63.2%). CONCLUSIONS: Sarcopenia affects 52.1% of patients with PWS, with 20.8% meeting criteria for severe sarcopenia. Ultrasound of the gastrocnemius medialis is a valid, radiation-free predictor of skeletal muscle mass and serves as a practical diagnostic tool for sarcopenic obesity in PWS. CI - (c) 2026 The Author(s). Journal of Cachexia, Sarcopenia and Muscle published by Wiley Periodicals LLC. FAU - Yu, Luo-Hua AU - Yu LH AD - Department of Physical Medicine and Rehabilitation, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. FAU - Wu, Hsin-Chi AU - Wu HC AD - Department of Physical Medicine and Rehabilitation, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. AD - Department of Medicine, Tzu Chi University, Hualien, Taiwan. FAU - Tzeng, I-Shiang AU - Tzeng IS AD - Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. FAU - Luo, Yan-Ting AU - Luo YT AD - Department of Physical Medicine and Rehabilitation, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. FAU - Tsai, Li-Ping AU - Tsai LP AD - Department of Pediatrics, Heping Fuyou Branch, Taipei City Hospital, Taipei, Taiwan. AD - Department of Molecular Biology and Human Genetics, College of Medicine, Tzu Chi University, Hualien, Taiwan. FAU - Chiu, Valeria AU - Chiu V AUID- ORCID: 0000-0002-5170-2964 AD - Department of Physical Medicine and Rehabilitation, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. AD - Department of Medicine, Tzu Chi University, Hualien, Taiwan. LA - eng GR - TCRD-TPE-112-28/Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation/ GR - TCRD-TPE-112-RT-5/Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation/ PT - Journal Article PT - Observational Study PL - Germany TA - J Cachexia Sarcopenia Muscle JT - Journal of cachexia, sarcopenia and muscle JID - 101552883 SB - IM MH - Humans MH - *Prader-Willi Syndrome/complications MH - *Sarcopenia/etiology/diagnosis/diagnostic imaging MH - Female MH - Cross-Sectional Studies MH - Ultrasonography/methods MH - Male MH - *Muscle, Skeletal/diagnostic imaging MH - Adult MH - Adolescent MH - Young Adult MH - Child PMC - PMC13246224 OTO - NOTNLM OT - Prader-Willi syndrome OT - body composition OT - sarcopenia OT - ultrasonography COIS- The authors declare no conflicts of interest. EDAT- 2026/06/09 00:33 MHDA- 2026/06/12 04:10 PMCR- 2026/06/08 CRDT- 2026/06/08 20:13 PHST- 2026/05/02 00:00 [revised] PHST- 2024/06/20 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/06/12 04:10 [medline] PHST- 2026/06/09 00:33 [pubmed] PHST- 2026/06/08 20:13 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - JCSM70326 [pii] AID - 10.1002/jcsm.70326 [doi] PST - ppublish SO - J Cachexia Sarcopenia Muscle. 2026 Jun;17(3):e70326. doi: 10.1002/jcsm.70326. PMID- 42259208 OWN - NLM STAT- MEDLINE DCOM- 20260724 LR - 20260724 IS - 1873-6297 (Electronic) IS - 0001-6918 (Linking) VI - 268 DP - 2026 Aug TI - A study on the impact of AI health monitoring devices on exercise persistence among physical education students. PG - 107176 LID - S0001-6918(26)00977-7 [pii] LID - 10.1016/j.actpsy.2026.107176 [doi] AB - OBJECTIVE: This study investigates how the use motivations of AI health monitoring devices influence exercise persistence in physical education students, focusing on the mediating role of exercise enjoyment and exercise commitment. METHOD: The researchers conducted a survey among 764 Chinese university students using the Motivation for Use Scale, the Physical Activity Enjoyment Scale, the Exercise Commitment Scale, and the Physical Exercise Adherence Scale. The proposed chain mediation model was subsequently tested and validated. RESULTS: (1) The use motivations of AI health monitoring devices show a significant positive association with exercise persistence. (2) Exercise enjoyment and exercise commitment demonstrate both independent and sequential mediation effects in the model, with the mediation effect of exercise commitment being relatively stronger. CONCLUSION: The study identifies important associations among use motivations, exercise enjoyment, exercise commitment, and exercise persistence, offering useful insights for future practices and research aimed at supporting exercise-related behaviors among physical education students. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Wang, Chunxiao AU - Wang C AD - College of Sports Science and Health, Harbin Sport University, Harbin, Heilongjiang, 150008, China. FAU - Meng, Nijia AU - Meng N AD - College of Sports Science and Health, Harbin Sport University, Harbin, Heilongjiang, 150008, China. FAU - Han, Peng AU - Han P AD - College of Sports Science and Health, Harbin Sport University, Harbin, Heilongjiang, 150008, China. FAU - Liu, Chunhua AU - Liu C AD - Center of Training and Competition, Harbin Sport University, Harbin, Heilongjiang, 150008, China. Electronic address: hrbipe2019@163.com. LA - eng PT - Journal Article DEP - 20260608 PL - Netherlands TA - Acta Psychol (Amst) JT - Acta psychologica JID - 0370366 SB - IM MH - Humans MH - Female MH - *Students/psychology MH - *Exercise/psychology MH - *Motivation MH - Male MH - *Physical Education and Training MH - Young Adult MH - Universities MH - Adult MH - Digital Health MH - Adolescent OTO - NOTNLM OT - Exercise commitment OT - Exercise enjoyment OT - Exercise persistence OT - Physical education students OT - The use motivations of AI health monitoring devices COIS- Declaration of competing interest The authors have no competing interests to declare that are relevant to the content of this article. EDAT- 2026/06/09 00:34 MHDA- 2026/07/24 06:35 CRDT- 2026/06/08 18:10 PHST- 2025/07/23 00:00 [received] PHST- 2026/05/26 00:00 [revised] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/07/24 06:35 [medline] PHST- 2026/06/09 00:34 [pubmed] PHST- 2026/06/08 18:10 [entrez] AID - S0001-6918(26)00977-7 [pii] AID - 10.1016/j.actpsy.2026.107176 [doi] PST - ppublish SO - Acta Psychol (Amst). 2026 Aug;268:107176. doi: 10.1016/j.actpsy.2026.107176. Epub 2026 Jun 8. PMID- 42258969 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260915 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 90 DP - 2026 Sep-Oct TI - Development and initial validation of the nursing practices, perceptions and barriers questionnaire for childhood obesity: A cross-sectional observational study. PG - 77-86 LID - S0882-5963(26)00252-6 [pii] LID - 10.1016/j.pedn.2026.05.045 [doi] AB - AIM: To develop and preliminarily validate a questionnaire assessing primary care nurses' practices, perceptions, and perceived barriers in managing childhood obesity. DESIGN: Sequential exploratory study conducted in three phases: item development, content validation, and a cross-sectional observational study with an initial psychometric validation. METHODS: Items were generated through a literature review, focus groups, and adaptation of an existing adult obesity instrument. A panel of six experts assessed content validity, clarity, coherence, and item adequacy. The final version 39-item questionnaire was distributed online to primary care nurses in Madrid, Spain; 253 complete responses were analyzed. Descriptive statistics were calculated. A preliminary Exploratory Factor Analysis was conducted on selected items. RESULTS: The overall content validity index was 0.96. The final instrument identified three areas: training and experience, practices and barriers, and knowledge of childhood obesity. Factor analyses supported coherent underlying dimensions for selected items, with acceptable internal consistency. Nurses reported positive attitudes toward addressing pediatric obesity but identified barriers such as limited consultation time, low treatment adherence, and intervention complexity. CONCLUSION: The NPPBQ-CO is a structured instrument with initial evidence of content validity, preliminary psychometric support and acceptable internal consistency. Further validation is warranted. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Miguel-Atanes, Cristina AU - Miguel-Atanes C AD - Department of Biological and Health Psychology, Faculty of Psychology, Autonomous University of Madrid, Spain. Electronic address: cristina.miguelatanes@gmail.com. FAU - Gomez-Lobo, Andrea Gil AU - Gomez-Lobo AG AD - Department of Biological and Health Psychology, Faculty of Psychology, Autonomous University of Madrid, Spain. Electronic address: andrea.gilg@uam.es. FAU - Solar, Maria AU - Solar M AD - TEA EDICIONES SAU, Madrid, Spain. FAU - Sepulveda, Ana Rosa AU - Sepulveda AR AD - Department of Biological and Health Psychology, Faculty of Psychology, Autonomous University of Madrid, Spain. Electronic address: anarosa.sepulveda@uam.es. LA - eng PT - Journal Article PT - Observational Study PT - Validation Study DEP - 20260608 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - Female MH - *Pediatric Obesity/nursing/diagnosis MH - Psychometrics MH - Reproducibility of Results MH - Child MH - Spain MH - Male MH - *Pediatric Nursing MH - Adult MH - Attitude of Health Personnel MH - *Primary Care Nursing OTO - NOTNLM OT - Nursing care OT - Nursing, practical OT - Pediatric obesity OT - Primary health care OT - Surveys and questionnaires COIS- Declaration of competing interest There is no conflict of interest regarding the publication of this article. EDAT- 2026/06/08 19:42 MHDA- 2026/09/07 23:34 CRDT- 2026/06/08 18:02 PHST- 2025/11/25 00:00 [received] PHST- 2026/05/28 00:00 [revised] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/09/07 23:34 [medline] PHST- 2026/06/08 19:42 [pubmed] PHST- 2026/06/08 18:02 [entrez] AID - S0882-5963(26)00252-6 [pii] AID - 10.1016/j.pedn.2026.05.045 [doi] PST - ppublish SO - J Pediatr Nurs. 2026 Sep-Oct;90:77-86. doi: 10.1016/j.pedn.2026.05.045. Epub 2026 Jun 8. PMID- 42258527 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 6 DP - 2026 TI - Spurious effects in random-intercept cross-lagged panel models: Results from simulations and reanalyses of data on self-esteem and problematic eating behaviors used by Beckers et al. (2023). PG - e0351302 LID - 10.1371/journal.pone.0351302 [doi] LID - e0351302 AB - The random-intercept cross-lagged panel model (RI-CLPM) is an extension of the traditional cross-lagged panel model. The RI-CPLM specifically addresses prospective effects within individuals. In the present simulations, we found that the RI-CLPM is susceptible to spurious findings when observed scores on the two variables are affected by common auto-correlated state factors. In reanalyses of empirical data, we found contradictory decreasing, increasing, and null prospective effects between within-individual levels of self-esteem and problematic eating behaviors among Dutch teenagers (N = 1856). These contradictory findings indicated that previously reported prospective effects may have been statistical artifacts. Caution is advised when using the RI-CLPM, as it may produce misleading results. Researchers are recommended to validate findings using alternative analyses, e.g., by examining person-mean centered scores. CI - Copyright: (c) 2026 Sorjonen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Sorjonen, Kimmo AU - Sorjonen K AUID- ORCID: 0000-0001-9930-057X AD - Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. FAU - Nilsonne, Gustav AU - Nilsonne G AD - Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. AD - Department of Psychology, Stockholm University, Stockholm, Sweden. FAU - Ghaderi, Ata AU - Ghaderi A AD - Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. FAU - Melin, Bo AU - Melin B AD - Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. LA - eng PT - Journal Article DEP - 20260608 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Self Concept MH - Adolescent MH - *Feeding Behavior/psychology MH - Female MH - *Feeding and Eating Disorders/psychology PMC - PMC13245769 COIS- The authors have declared that no competing interests exist. EDAT- 2026/06/08 19:39 MHDA- 2026/06/15 11:30 PMCR- 2026/06/08 CRDT- 2026/06/08 13:44 PHST- 2025/08/04 00:00 [received] PHST- 2026/05/22 00:00 [accepted] PHST- 2026/06/15 11:30 [medline] PHST- 2026/06/08 19:39 [pubmed] PHST- 2026/06/08 13:44 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - PONE-D-25-39381 [pii] AID - 10.1371/journal.pone.0351302 [doi] PST - epublish SO - PLoS One. 2026 Jun 8;21(6):e0351302. doi: 10.1371/journal.pone.0351302. eCollection 2026. PMID- 42258187 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260803 IS - 2168-6211 (Electronic) IS - 2168-6203 (Print) IS - 2168-6203 (Linking) VI - 180 IP - 8 DP - 2026 Aug 1 TI - Smartphone Acquisition and Use at Age 13 Years and Health Outcomes at Age 14 Years. PG - 858-866 LID - 10.1001/jamapediatrics.2026.2118 [doi] AB - IMPORTANCE: Smartphone acquisition and use under age 13 years is common and has been linked to adverse health implications. Although delaying acquisition until after age 13 years is often recommended, evidence supporting this guideline remains limited. OBJECTIVE: To quantify the associations of smartphone acquisition around age 13 years and smartphone use with depression, obesity, and insufficient sleep at age 14 years. DESIGN, SETTING, AND PARTICIPANTS: In this cohort study of youth from the Adolescent Brain Cognitive Development Study, eligible participants were study participants who did not have a smartphone by the 13-year-old assessment. Mixed-effects regression models were applied to quantify associations of past-year smartphone acquisition and use with health outcomes adjusting for pre-exposure depression, obesity and sleep, multiple socioeconomic and parental confounders, and use of other devices. Analyses were conducted between November 2025 and April 2026. EXPOSURES: Smartphone acquisition and self-reported smartphone use duration (smartphone time). MAIN OUTCOMES: Odds ratios (ORs) for associations with depression diagnosis (based on a validated computerized diagnostic assessment), obesity (body mass index above 95th percentile), and insufficient sleep (less than 8 hours/night). RESULTS: Participants included 1959 youth (803 girls [41.0%]; 292 Black [14.9%], 314 Hispanic [16.0%], 1661 White [84.8%]) followed up from the 3-year (mean [SD] age, 12.7 [0.6] years) to the 4-year (mean [SD] age, 14.0 [0.7] years) assessment. Between the 3- and 4-year assessments, 1230 participants acquired a smartphone and 729 did not. Smartphone acquisition was not significantly associated with depression (OR, 1.45; 95% CI, 0.98-2.14) or obesity (OR, 1.02; 95% CI, 0.71-1.46), but was associated with insufficient sleep (OR, 1.29; 95% CI, 1.03-1.62) at follow-up. Among those who had acquired a smartphone, total smartphone time (standardized z score) was associated with depression (OR, 1.22; 95% CI, 1.01-1.80), obesity (OR, 1.34; 95% CI, 1.09-1.65), and insufficient sleep (OR, 1.28; 95% CI, 1.12-1.47). Placing smartphones outside the bedroom at bedtime was associated with lower odds of insufficient sleep (OR, 0.64; 95% CI, 0.47-0.87). CONCLUSIONS AND RELEVANCE: The results of this cohort study suggest that simply smartphone acquisition at age 13 years was not associated with depression or with obesity, but was associated with insufficient sleep at age 14 years; however, the amount of smartphone use was associated with higher odds of all 3 outcomes. Behavioral interventions like limiting smartphone time and keeping smartphones out of bedrooms at night may protect adolescents from potential adverse health outcomes. Findings offer insights to guide caregivers on adolescent smartphone use and inform policies aimed at protecting youth, such as delaying smartphone acquisition until age 13 years. FAU - Bren, Ziv AU - Bren Z AD - Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia (CHOP), Philadelphia, Pennsylvania. AD - Lifespan Brain Institute of CHOP and Penn Medicine, Philadelphia, Pennsylvania. FAU - Tran, Kate T AU - Tran KT AD - Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia (CHOP), Philadelphia, Pennsylvania. AD - Lifespan Brain Institute of CHOP and Penn Medicine, Philadelphia, Pennsylvania. FAU - Visoki, Elina AU - Visoki E AD - Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia (CHOP), Philadelphia, Pennsylvania. AD - Lifespan Brain Institute of CHOP and Penn Medicine, Philadelphia, Pennsylvania. FAU - Waasdorp, Tracy E AU - Waasdorp TE AD - Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia (CHOP), Philadelphia, Pennsylvania. AD - Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia. FAU - Moore, Tyler M AU - Moore TM AD - Lifespan Brain Institute of CHOP and Penn Medicine, Philadelphia, Pennsylvania. AD - Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia. FAU - Pimentel, Samuel D AU - Pimentel SD AD - Department of Statistics, University of California, Berkeley. FAU - Barzilay, Ran AU - Barzilay R AD - Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia (CHOP), Philadelphia, Pennsylvania. AD - Lifespan Brain Institute of CHOP and Penn Medicine, Philadelphia, Pennsylvania. AD - Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia. LA - eng PT - Journal Article PL - United States TA - JAMA Pediatr JT - JAMA pediatrics JID - 101589544 SB - IM MH - Humans MH - *Smartphone/statistics & numerical data MH - Adolescent MH - Female MH - Male MH - *Depression/epidemiology/etiology MH - *Obesity/epidemiology MH - Cohort Studies MH - *Pediatric Obesity/epidemiology MH - *Sleep Deprivation/epidemiology MH - Sleep Duration PMC - PMC13247848 COIS- Conflict of Interest Disclosures: Dr Visoki reported that her spouse is the founder and CEO of Kidas. Dr Barzilay reported grants from National Institute of Mental Health (NIMH) during the conduct of the study; he reported advisory board service with Children and Screens and with Taliaz Health, in which he also holds equity, outside the submitted work. No other disclosures were reported. EDAT- 2026/06/08 12:39 MHDA- 2026/08/03 12:42 PMCR- 2027/06/08 CRDT- 2026/06/08 11:33 PHST- 2026/08/03 12:42 [medline] PHST- 2026/06/08 12:39 [pubmed] PHST- 2026/06/08 11:33 [entrez] PHST- 2027/06/08 00:00 [pmc-release] AID - 2849461 [pii] AID - poi260030 [pii] AID - 10.1001/jamapediatrics.2026.2118 [doi] PST - ppublish SO - JAMA Pediatr. 2026 Aug 1;180(8):858-866. doi: 10.1001/jamapediatrics.2026.2118. PMID- 42257889 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261028 IS - 1435-165X (Electronic) IS - 1018-8827 (Linking) VI - 35 IP - 9 DP - 2026 Sep TI - Impact of school physical activity on physical and mental health in children and adolescents: A Meta-analysis based on RE-AIM. PG - 2685-2702 LID - 10.1007/s00787-026-03069-5 [doi] AB - The RE-AIM framework was used to assess and analyze the impact of school physical activity on children and adolescents' physical and mental health. A search of PubMed, Cochrane Library, Embase, Scopus, EBSCO, and Web of Science was conducted from when the databases were created until December 2024. Articles included studies on school-based physical activity interventions and physical and mental health of children and adolescents. The screened literature was evaluated for quality, data extraction, standardized mean difference (SMD), Mean difference(MD) and confidence intervals (95% CI) were used as effect indicators. Two researchers independently screened the literature, extracted data, and assessed the risk of bias for the included studies. Preferred reporting items were used using systematic evaluation and meta-analysis guidelines combined with meta-analysis with the RE-AIM framework. A total of 19 studies that met the inclusion criteria were included in the meta-analysis, and the results of the meta-analysis showed that school physical activity improved adolescents' and children's athletic ability (SMD = 0.33, 95% CI = 0.23 ~ 0.43), reduced BMI (MD=-0.50, 95% CI=-0.81~-0.19) and improved Fitness self-perceptions (SMD = 0.31, 95% CI = 0.22 ~ 0.40). In terms of mental health, school physical activity improved children and adolescents' self-reported questionnaire scores (SMD = 0.21,95%CI = 0.12 ~ 0.30) and reduced anxiety, depression and stress levels (MD=-0.53,95%CI=-0.85~-0.22). That is, school physical activity is associated with improvements in both physical health and the mental health of adolescents and children. In addition, the RE-AIM framework reported the effectiveness of sports interventions on health, with higher proportions of the Reach, Efficacy, and Adoption dimensions in the RE-AIM framework than in Implementation and Maintenance. A comprehensive assessment of the impact of school physical activity was conducted through meta-analysis and RE-AIM framework, which showed that school physical activity is associated with improvements in both the physical and mental health of children and adolescents and that RE-AIM framework reported the quality of physical activity interventions to improve the physical and mental health of children and adolescents, achieving a balance of internal and external validity in comparison. CI - (c) 2026. Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Li, Congcong AU - Li C AD - College of Sports Science, Shenyang Normal University, Shenyang, China. AD - Department of Physical Education, Shanghai University of Medicine & Health Science, Shanghai, China. FAU - Wang, Yezheng AU - Wang Y AD - College of Sports Science, Shenyang Normal University, Shenyang, China. FAU - Zhao, Wei AU - Zhao W AD - College of Sports Science, Shenyang Normal University, Shenyang, China. FAU - Yan, Xu AU - Yan X AD - College of Sports Science, Shenyang Normal University, Shenyang, China. FAU - Liu, Kaihang AU - Liu K AD - College of Sports Science, Shenyang Normal University, Shenyang, China. FAU - Zhong, Jingyi AU - Zhong J AD - College of Sports Science, Shenyang Normal University, Shenyang, China. FAU - Wang, Liyan AU - Wang L AD - College of Rehabilitation, Shanghai University of Medicine & Health Science, Shanghai, China. FAU - Wang, Hongbiao AU - Wang H AD - Department of Physical Education, Shanghai University of Medicine & Health Science, Shanghai, China. FAU - Wang, Lijuan AU - Wang L AD - College of Sports Science, Shenyang Normal University, Shenyang, China. wlj_sunny@synu.edu.cn. LA - eng PT - Journal Article PT - Meta-Analysis PT - Review DEP - 20260608 PL - Germany TA - Eur Child Adolesc Psychiatry JT - European child & adolescent psychiatry JID - 9212296 SB - IM MH - Humans MH - Adolescent MH - Child MH - *Exercise/psychology MH - *Mental Health MH - *Schools MH - *Physical Fitness OTO - NOTNLM OT - Adolescents OT - Children OT - Mental health OT - Physical activity OT - Physical health OT - School interventions COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/06/08 12:39 MHDA- 2026/10/25 03:35 CRDT- 2026/06/08 11:13 PHST- 2025/05/22 00:00 [received] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/10/25 03:35 [medline] PHST- 2026/06/08 12:39 [pubmed] PHST- 2026/06/08 11:13 [entrez] AID - 10.1007/s00787-026-03069-5 [pii] AID - 10.1007/s00787-026-03069-5 [doi] PST - ppublish SO - Eur Child Adolesc Psychiatry. 2026 Sep;35(9):2685-2702. doi: 10.1007/s00787-026-03069-5. Epub 2026 Jun 8. PMID- 42257240 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260612 IS - 1473-0766 (Electronic) IS - 0951-3590 (Linking) VI - 42 IP - 1 DP - 2026 Dec 31 TI - Association between GLM7 and female infertility: a cross-sectional analysis of NHANES 2013-2018. PG - 2686485 LID - 10.1080/09513590.2026.2686485 [doi] AB - OBJECTIVE: Female infertility is a common reproductive disorder influenced by metabolic dysfunction. The glycolipid metabolism 7 factors (GLM7) is a composite metabolic index integrating age, BMI, glucose, insulin, and lipid profiles. This study aimed to examine its association with female infertility in a nationally representative population. METHODS: Data from 1,405 female participants aged 18-45 years from the 2013-2018 cycles of the National Health and Nutrition Examination Survey were analyzed. We used survey-weighted logistic regression models and restricted cubic splines to assess the association between GLM7 and infertility. Receiver operating characteristic (ROC) curves were used to assess the diagnostic accuracy. RESULTS: A total of 167 participants (11.9%) reported infertility. After full adjustment, higher GLM7 levels were independently associated with increased odds of infertility (odds ratio (OR) = 1.401, 95% CI: 1.028-1.909, p = 0.034). A positive linear association was observed, with a potential plateau effect at GLM7 approximately 6.98. GLM7 showed modest discriminative ability (AUC = 0.596, 95%CI: 0.552-0.639). CONCLUSIONS: GLM7 was positively associated with female infertility. As a multidimensional metabolic indicator, GLM7 may provide complementary information for reproductive health research. However, its modest discriminative performance suggests limited value as a standalone screening tool, warranting further validation in longitudinal and clinical studies. FAU - Dong, Tingting AU - Dong T AUID- ORCID: 0000-0003-1035-6687 AD - Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong Province, People's Republic of China. FAU - Gao, Jie AU - Gao J AUID- ORCID: 0009-0006-8586-0772 AD - School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, People's Republic of China. FAU - Wang, Xietong AU - Wang X AUID- ORCID: 0009-0006-3301-9105 AD - Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong Province, People's Republic of China. AD - Shandong Provincial Maternal and Child Health Care Hospital, Jinan, Shandong Province, People's Republic of China. AD - Key Laboratory of Maternal-Fetal Medicine of National Health Commission of China, Maternal and Child Health Care Hospital of Shandong Province Affiliated with Qingdao University, Qingdao University, Jinan, Shandong Province, People's Republic of China. LA - eng PT - Journal Article DEP - 20260608 PL - England TA - Gynecol Endocrinol JT - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JID - 8807913 RN - 0 (Blood Glucose) SB - IM MH - Humans MH - Female MH - Adult MH - *Infertility, Female/blood/epidemiology/metabolism MH - Cross-Sectional Studies MH - Young Adult MH - Nutrition Surveys MH - Adolescent MH - Middle Aged MH - United States/epidemiology MH - Body Mass Index MH - Blood Glucose/metabolism OTO - NOTNLM OT - Female OT - GLM7 OT - glycolipid metabolism OT - infertility OT - reproductive health EDAT- 2026/06/08 12:39 MHDA- 2026/06/12 06:37 CRDT- 2026/06/08 07:47 PHST- 2026/06/12 06:37 [medline] PHST- 2026/06/08 12:39 [pubmed] PHST- 2026/06/08 07:47 [entrez] AID - 10.1080/09513590.2026.2686485 [doi] PST - ppublish SO - Gynecol Endocrinol. 2026 Dec 31;42(1):2686485. doi: 10.1080/09513590.2026.2686485. Epub 2026 Jun 8. PMID- 42257148 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260608 LR - 20260813 IS - 2249-4863 (Print) IS - 2278-7135 (Electronic) IS - 2249-4863 (Linking) VI - 15 IP - 3 DP - 2026 Mar TI - Exploring the effects of high fat, salt, and sugar (HFSS) food consumption among undergraduate medical students: A cross-sectional study. PG - 1306-1314 LID - 10.4103/jfmpc.jfmpc_94_25 [doi] AB - BACKGROUND: Adolescents who are overweight or obese are more likely to develop non-communicable diseases (NCDs) in their early adult years, including diabetes, cardiovascular disease, hypertension, and dyslipidaemia. To address the growing epidemic of childhood and adult obesity, immediate action is needed. Obesity and the prevalence of non-communicable diseases are strongly linked to eating habits. METHODOLOGY: A pre-tested, validated questionnaire was circulated among undergraduate MBBS students from various medical colleges. RESULTS: One hundred seventy MBBS students from four other medical colleges participated in this online survey. The questionnaire was circulated via Google Forms. The mean age of participants was 21.57 (+1.47). Zomato (57, 33%) and Swiggy (52, 31%) were the most used applications by the participants. One hundred thirty-four (79%) participants had incorrect knowledge about added sugar in the diet cola drinks. One hundred nineteen (70%) participants had incorrect knowledge about added salt in bread. Thirty-five of 107 (33%) females had a waist hip ratio (WHR) of more than 0.85, and 15/63 (24%) males had a WHR of more than 0.90, which implies an increased chance of obesity, cardiovascular risks, and other non-communicable diseases in the future. CONCLUSION: The study reveals a high prevalence of HFSS food consumption among undergraduate medical students, with online food delivery platforms playing a central role in facilitating this dietary behaviour. CI - Copyright: (c) 2026 Journal of Family Medicine and Primary Care. FAU - Singh, Garima AU - Singh G AD - Department of Community Medicine, Heritage Institute of Medical Sciences, Varanasi, Uttar Pradesh, India. FAU - Jaiswal, Abhishek AU - Jaiswal A AD - Department of Community Medicine, Banaras Hindu University, Varanasi, Uttar Pradesh, India. LA - eng PT - Journal Article DEP - 20260420 PL - India TA - J Family Med Prim Care JT - Journal of family medicine and primary care JID - 101610082 PMC - PMC13241118 OTO - NOTNLM OT - Fast food consumption OT - non-communicable diseases OT - obesity COIS- There are no conflicts of interest. EDAT- 2026/06/08 12:38 MHDA- 2026/06/08 12:39 PMCR- 2026/03/01 CRDT- 2026/06/08 07:46 PHST- 2025/01/15 00:00 [received] PHST- 2026/01/16 00:00 [revised] PHST- 2026/02/11 00:00 [accepted] PHST- 2026/06/08 12:39 [medline] PHST- 2026/06/08 12:38 [pubmed] PHST- 2026/06/08 07:46 [entrez] PHST- 2026/03/01 00:00 [pmc-release] AID - JFMPC-15-1306 [pii] AID - 10.4103/jfmpc.jfmpc_94_25 [doi] PST - ppublish SO - J Family Med Prim Care. 2026 Mar;15(3):1306-1314. doi: 10.4103/jfmpc.jfmpc_94_25. Epub 2026 Apr 20. PMID- 42257122 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260608 LR - 20260813 IS - 2249-4863 (Print) IS - 2278-7135 (Electronic) IS - 2249-4863 (Linking) VI - 15 IP - 3 DP - 2026 Mar TI - Screen time and its determinants among adolescents in Chennai: A cross-sectional study. PG - 1160-1164 LID - 10.4103/jfmpc.jfmpc_442_25 [doi] AB - BACKGROUND: Screen time (ST) has become a critical factor influencing adolescent health. With the rapid expansion of smartphones, tablets, computers and internet access, the ways in which they interact with their environment have undergone massive transformation. This study focuses on the use of screen time and its association with demographic and lifestyle factors in Chennai, India. METHODS: The study was a descriptive cross-sectional study among 610 adolescents (53.3% from government aided schools and 46.7% from private school) from Chennai. Data was collected using structured proforma and validated questionnaire (QueST) that was then analysed for ST determinants. RESULTS: The study revealed an average ST of 2.45 +/- 1.19 hours on weekdays and 4.21 +/- 1.94 hours on weekends. Recreational activities such as video, gaming and social media were the predominant contributors. Increased ST (>2 hours/day) was significantly associated with age (17 years), gender (female), type of school (private), decreased sleep duration, absence of physical activity, incomplete homework, lack of peer interaction, spectacle use and overweight/obesity. CONCLUSION: The average ST spent by adolescents is more than the recommendation. This study highlights the need for optimal ST practices for promoting a balanced lifestyle among Adolescents. CI - Copyright: (c) 2026 Journal of Family Medicine and Primary Care. FAU - Amuthan, Shwetha AU - Amuthan S AD - Senior Resident, Department of Paediatrics, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India. FAU - Mohan, Ram AU - Mohan R AD - Assistant Professor, Department of Paediatrics, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India. FAU - Ravichandran, Latha AU - Ravichandran L AD - Professor, Department of Paediatrics, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India. FAU - Premkumar, Sarala AU - Premkumar S AD - Professor, Department of Paediatrics, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India. LA - eng PT - Journal Article DEP - 20260420 PL - India TA - J Family Med Prim Care JT - Journal of family medicine and primary care JID - 101610082 PMC - PMC13241144 OTO - NOTNLM OT - Adolescents OT - BMI OT - Chennai OT - physical activity OT - screentime COIS- There are no conflicts of interest. EDAT- 2026/06/08 12:39 MHDA- 2026/06/08 12:40 PMCR- 2026/03/01 CRDT- 2026/06/08 07:46 PHST- 2025/03/17 00:00 [received] PHST- 2025/10/25 00:00 [revised] PHST- 2025/11/03 00:00 [accepted] PHST- 2026/06/08 12:40 [medline] PHST- 2026/06/08 12:39 [pubmed] PHST- 2026/06/08 07:46 [entrez] PHST- 2026/03/01 00:00 [pmc-release] AID - JFMPC-15-1160 [pii] AID - 10.4103/jfmpc.jfmpc_442_25 [doi] PST - ppublish SO - J Family Med Prim Care. 2026 Mar;15(3):1160-1164. doi: 10.4103/jfmpc.jfmpc_442_25. Epub 2026 Apr 20. PMID- 42256855 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260608 LR - 20260813 IS - 1662-5153 (Print) IS - 1662-5153 (Electronic) IS - 1662-5153 (Linking) VI - 20 DP - 2026 TI - Quantum-entangled feature selection and spiking graph transformer networks for early detection of childhood behavioral markers. PG - 1797210 LID - 10.3389/fnbeh.2026.1797210 [doi] LID - 1797210 AB - INTRODUCTION: Early identification of childhood behavioural markers using wearable sensing is important for timely intervention in developmental and sleep-related disorders. Wrist-worn accelerometer data provide objective measures of behavioural regulation by capturing actigraphy-derived states such as Sleep, Wake, and Transitional periods. However, existing deep learning methods for behavioural state detection often face challenges related to redundant features, sensitivity to sensor noise, limited robustness in long-term wearable deployment, and high energy consumption. METHODS: This study proposes a Quantum Variational Feature Selection-Spiking Graph Transformer Network (QVFS-SGTN), a hybrid quantum-neuromorphic framework for robust and energy-efficient behavioural state classification. The prediction task was defined as a three-class classification problem involving Sleep, Wake, and Transitional behavioural states from high-frequency wrist-worn accelerometer data. The proposed model integrates a parameterized quantum circuit-based feature selector to identify non-linear and entangled sensor correlations. Selected features are then processed by a spiking graph transformer network, which models temporal dependencies through event-driven self-attention and neuromorphic neuron dynamics. Experiments were conducted using the Child Mind Institute wearable dataset, with additional cross-dataset validation performed on the external Multi-Ethnic Study of Atherosclerosis sleep dataset. RESULTS: The proposed QVFS-SGTN framework achieved state-of-the-art performance on the Child Mind Institute wearable dataset, with an accuracy of 0.968, an F1-score of 0.968, and an AUC of 0.991. Robustness evaluation demonstrated stable performance under significant Gaussian noise, maintaining accuracy above 92%. Energy analysis showed a 40-55% reduction in computational cost compared with conventional deep learning models. In cross-dataset evaluation using the MESA sleep dataset, the model achieved an accuracy of 0.931 without fine-tuning, indicating strong generalization capability. DISCUSSION: The findings demonstrate that combining quantum-enhanced feature selection with spiking graph-based temporal modelling can improve the robustness, accuracy, and energy efficiency of wearable behavioural state detection. The QVFS-SGTN framework effectively addresses key limitations of existing deep learning approaches, including feature redundancy, sensor noise sensitivity, and computational cost. These results support the potential of the proposed hybrid quantum-neuromorphic model for scalable, long-term, real-world paediatric behavioural monitoring. CI - Copyright (c) 2026 M, Joseph, Patil and K. FAU - M, Karthiga AU - M K AD - Department of Computer Science and Engineering, Bannari Amman Institute of Technology, Sathyamangalam, Tamil Nadu, India. AD - Postdoctoral Researcher, Multimedia University, Melaka, Malaysia. FAU - Joseph, Emerson Raja AU - Joseph ER AD - Faculty of Engineering and Technology Centre for Advanced Analytics, COE of Artificial Intelligence, Multimedia University, Melaka, Malaysia. FAU - Patil, Subhash AU - Patil S AD - Department of Surgery, International Medical University, Management and Science University, Shah Alam, Malaysia. FAU - K, Saranya AU - K S AD - Department of Computer Science and Engineering, Bannari Amman Institute of Technology, Sathyamangalam, Tamil Nadu, India. LA - eng PT - Journal Article DEP - 20260522 PL - Switzerland TA - Front Behav Neurosci JT - Frontiers in behavioral neuroscience JID - 101477952 PMC - PMC13236668 OTO - NOTNLM OT - childhood behavioral markers OT - graph transformer OT - neuromorphic computing OT - quantum variational feature selection OT - sleep-wake detection OT - spiking neural networks OT - wearable accelerometers COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/08 12:39 MHDA- 2026/06/08 12:40 PMCR- 2026/05/22 CRDT- 2026/06/08 07:44 PHST- 2026/01/27 00:00 [received] PHST- 2026/04/27 00:00 [revised] PHST- 2026/04/29 00:00 [accepted] PHST- 2026/06/08 12:40 [medline] PHST- 2026/06/08 12:39 [pubmed] PHST- 2026/06/08 07:44 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - 10.3389/fnbeh.2026.1797210 [doi] PST - epublish SO - Front Behav Neurosci. 2026 May 22;20:1797210. doi: 10.3389/fnbeh.2026.1797210. eCollection 2026. PMID- 42256484 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2421-4248 (Electronic) IS - 1121-2233 (Print) IS - 1121-2233 (Linking) VI - 66 IP - 4 DP - 2025 Dec TI - The digital tether: a SA-SV based survey on smartphone addiction among young adults in Southern Italy. PG - E466-E478 LID - 10.15167/2421-4248/jpmh2025.66.4.3771 [doi] AB - INTRODUCTION: In the post-pandemic era, smartphone usage has surged globally, particularly among young adults. While these devices offer convenience and connectivity, their excessive use has raised concerns about behavioral addiction and psychological well-being. This study investigates the prevalence of problematic smartphone use among young adults in Southern Italy, focusing on usage patterns and socio-demographic correlations. METHODS: A cross-sectional survey was conducted between March and June 2025 using an anonymous online questionnaire. The instrument combined ad hoc questions on lifestyle and digital habits with the validated Smartphone Addiction Scale-Short Version (SAS-SV). Participants aged 18-40 were recruited primarily from Sicily and Calabria via university and community networks. Data were analyzed using non-parametric statistical tests and chi-square analysis. RESULTS: The final sample included 451 respondents (average age: 22.42 years), predominantly Italian and non-working students. The SAS-SV identified smartphone addiction in 21.3% of participants, with no significant gender differences. Most users engaged with smartphones for leisure, social media, and entertainment. Significant associations were found between SAS scores and variables such as region, education level, and income. Notably, higher scores correlated with emotional reliance on smartphones and difficulty disengaging from use. CONCLUSION: Problematic smartphone use affects over one-fifth of young adults in Southern Italy, driven more by app features than screen time alone. These findings underscore the need for targeted public health strategies, including early screening and behavioral interventions, to address digital dependency and promote healthier technology habits in this demographic. CI - (c)2026 Pacini Editore SRL, Pisa, Italy. FAU - Venuto, Roberto AU - Venuto R AD - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy. AD - Department of Prevention, Local Health Authority of Messina, Messina, Italy. FAU - Rizzo, Caterina Elisabetta AU - Rizzo CE AD - Department of Prevention, Local Health Authority of Messina, Messina, Italy. AD - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. FAU - Genovese, Giovanni AU - Genovese G AD - Department of Prevention, Local Health Authority of Messina, Messina, Italy. AD - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. FAU - Trimarchi, Giuseppe AU - Trimarchi G AD - SIR, University of Messina, Messina, Italy. FAU - LA Spada, Giuseppe AU - LA Spada G AD - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. FAU - Squeri, Raffaele AU - Squeri R AD - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. FAU - LA Fauci, Vincenza AU - LA Fauci V AD - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. FAU - Genovese, Cristina AU - Genovese C AD - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. LA - eng PT - Journal Article DEP - 20260228 PL - Italy TA - J Prev Med Hyg JT - Journal of preventive medicine and hygiene JID - 9214440 SB - IM MH - Humans MH - *Smartphone/statistics & numerical data MH - Italy/epidemiology MH - Female MH - Young Adult MH - Male MH - Cross-Sectional Studies MH - Adolescent MH - Surveys and Questionnaires MH - *Internet Addiction Disorder/epidemiology MH - Adult MH - *Behavior, Addictive/epidemiology MH - Prevalence MH - Digital Media PMC - PMC13235401 OTO - NOTNLM OT - Digital behavior OT - SAS-SV OT - Smartphone addiction OT - Smartphone problematic use OT - Young adults COIS- The authors declare no conflict of interest. EDAT- 2026/06/08 12:38 MHDA- 2026/06/12 06:39 PMCR- 2026/02/28 CRDT- 2026/06/08 07:41 PHST- 2026/06/12 06:39 [medline] PHST- 2026/06/08 12:38 [pubmed] PHST- 2026/06/08 07:41 [entrez] PHST- 2026/02/28 00:00 [pmc-release] AID - 10.15167/2421-4248/jpmh2025.66.4.3771 [doi] PST - epublish SO - J Prev Med Hyg. 2026 Feb 28;66(4):E466-E478. doi: 10.15167/2421-4248/jpmh2025.66.4.3771. eCollection 2025 Dec. PMID- 42256013 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260608 LR - 20260813 IS - 2641-7804 (Electronic) IS - 2641-7804 (Linking) VI - 7 IP - 4 DP - 2025 TI - Associations Between Social Media Usage, Physical Activity and Flourishing in Rural University Students. PG - 128-136 LID - 10.13023/jah.0704.08 [doi] AB - INTRODUCTION: Most adolescents and young adults report significant use of social media.1-3 However, there is limited research on the effect of social media use, specifically on physical activity and flourishing. PURPOSE: This pilot research study examines the correlation between social media usage and the physical activity and flourishing levels of college students at a rural university in Appalachia. METHODS: The authors conducted a survey including the validated Secure Flourishing Index and Stanford Leisure-Time Activity Categorical Item, containing questions on social media use and demographics. Spearman's rho was used for nonparametric correlations. Pearson's correlation was used to determine the correlation of flourishing with physical activity levels. RESULTS: Time spent on Threads per login was positively associated with higher physical activity (pppp <0.001). Implications: Social media use, both frequency and time spent on the platforms, can impact how college students attending a rural university flourish and participate in physical activity. Continued research in this area should investigate the content on social media for its impact on different domains of flourishing including physical and mental health. CI - Copyright (c) 2025 Anna Dysart and Minu Sara Thomas. FAU - Dysart, Anna AU - Dysart A AD - Western Carolina University. FAU - Thomas, Minu Sara AU - Thomas MS AD - Western Carolina University. LA - eng PT - Journal Article DEP - 20251201 PL - United States TA - J Appalach Health JT - Journal of Appalachian health JID - 101747123 PMC - PMC13239628 OTO - NOTNLM OT - Appalachia OT - college students OT - flourishing OT - health OT - physical activity OT - social media COIS- Cover Page Footnote: No competing financial or editorial interests were reported by the authors of this paper. EDAT- 2026/06/08 12:39 MHDA- 2026/06/08 12:40 PMCR- 2025/12/01 CRDT- 2026/06/08 07:37 PHST- 2026/06/08 12:40 [medline] PHST- 2026/06/08 12:39 [pubmed] PHST- 2026/06/08 07:37 [entrez] PHST- 2025/12/01 00:00 [pmc-release] AID - jah-7-4-128 [pii] AID - 10.13023/jah.0704.08 [doi] PST - epublish SO - J Appalach Health. 2025 Dec 1;7(4):128-136. doi: 10.13023/jah.0704.08. eCollection 2025. PMID- 42255899 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260608 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Genotype-phenotype correlations in EPCAM-associated congenital tufting enteropathy: a case report and systematic review. PG - 1830464 LID - 10.3389/fped.2026.1830464 [doi] LID - 1830464 AB - BACKGROUND: Congenital tufting enteropathy (CTE) is a rare autosomal-recessive enteropathy caused by EPCAM variants. While the clinical spectrum ranges from intractable diarrhea to manageable outcomes, the genotype-phenotype correlation remains undefined. METHODS: We report a case of an infant diagnosed with CTE carrying a novel frameshift variant (c.315delT), and present a systematic review of previously published molecularly confirmed cases. Genotypes were stratified into truncating (nonsense, frameshift, large deletions) and non-truncating (missense, splicing, in-frame indel) groups to assess their impact on intestinal failure severity. RESULTS: The index patient, carrying a homozygous truncating variant, presented with severe malnutrition and intestinal failure. In the pooled cohort (n = 150), truncating variants were significantly associated with dependency on total parenteral nutrition (TPN) compared to non-truncating variants (OR 2.37, 95% CI 1.15-4.90, p = 0.020). Sensitivity analysis supported this association (OR 2.42, 95% CI 1.07-5.47, p = 0.045). Geographically, truncating variants were enriched in the Eastern Mediterranean Region (OR 9.32, p < 0.001). CONCLUSIONS: Truncating EPCAM variants showed a preliminary but significant clinical association with severe intestinal failure requiring TPN. These findings support early risk stratification for aggressive nutritional management but warrant further validation in prospective cohorts. CI - (c) 2026 Zhao, Zheng, Liu, Liu, Lu and Yan. FAU - Zhao, Liqian AU - Zhao L AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Zheng, Yucan AU - Zheng Y AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Liu, Hao AU - Liu H AD - Department of Infection, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Liu, Zhifeng AU - Liu Z AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Lu, Yan AU - Lu Y AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Yan, Kunlong AU - Yan K AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. LA - eng PT - Journal Article DEP - 20260521 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13233504 OTO - NOTNLM OT - EPCAM OT - congenital tufting enteropathy OT - genotype-phenotype analysis OT - intestinal failure OT - parenteral nutrition COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/08 12:38 MHDA- 2026/06/08 12:39 PMCR- 2026/05/21 CRDT- 2026/06/08 07:36 PHST- 2026/03/14 00:00 [received] PHST- 2026/05/01 00:00 [revised] PHST- 2026/05/01 00:00 [accepted] PHST- 2026/06/08 12:39 [medline] PHST- 2026/06/08 12:38 [pubmed] PHST- 2026/06/08 07:36 [entrez] PHST- 2026/05/21 00:00 [pmc-release] AID - 10.3389/fped.2026.1830464 [doi] PST - epublish SO - Front Pediatr. 2026 May 21;14:1830464. doi: 10.3389/fped.2026.1830464. eCollection 2026. PMID- 42254656 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260813 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Fecal microbiota composition concerning body mass index and early-life factors in Mexican preschool-aged children: a cross-sectional study. PG - e21253 LID - 10.7717/peerj.21253 [doi] LID - e21253 AB - BACKGROUND: The gut microbiota maturation extends beyond the first two years of life. Early perinatal and postnatal factors may influence the child's nutritional status, which, in turn, can affect the composition of their gut microbiota. METHODS: This cross-sectional study characterized the gut microbiota of 84 preschool children (ages 3 to 5) from semi-urban and urban areas in Veracruz, Mexico. Fecal samples were analyzed using 16S rRNA gene sequencing. Perinatal and early-life exposures were retrieved retrospectively using a validated, interviewer-administered questionnaire, while current anthropometric measurements and dietary patterns were evaluated. Children were classified by Body Mass Index (BMI) as underweight (UW), normal weight (NW), or overweight/obese (OW). RESULTS: Clinical factors such as prematurity and early feeding showed weak associations with BMI. The dietary patterns exhibited general homogeneity, showing a Western diet with no significant changes in relation to BMI. The predominant bacterial phyla were Bacillota and Bacteroidota across all BMI groups. Alpha diversity showed significant differences according to BMI categories, while no significant differences in beta diversity, or the relative abundance of major phyla, were observed. At the family level, Prevotellaceae was more abundant in underweight children, while Lachnospiraceae was more prevalent in those with higher BMI. However, these trends were not statistically significant. The findings suggest that, within this narrow age range and shared environment, gut microbiota composition is broadly similar regardless of BMI and dietary patterns, highlighting the complexity of microbiota-host interactions in early childhood. Further studies integrating functional analyses are needed to clarify the causal links between gut microbiota and a child's weight status. CI - (c)2026 Hernandez-Rodriguez et al. FAU - Hernandez-Rodriguez, Dolores AU - Hernandez-Rodriguez D AD - Instituto de Ciencias Basicas, Universidad Veracruzana, Xalapa, Veracruz, Mexico. FAU - Contreras, Astrid AU - Contreras A AD - Centro de Investigaciones Biomedicas, Universidad Veracruzana, Xalapa, Veracruz, Mexico. FAU - Melgar Lalanne, Guiomar AU - Melgar Lalanne G AD - Instituto de Ciencias Basicas, Universidad Veracruzana, Xalapa, Veracruz, Mexico. FAU - Lara Arellano, Silvia Socorro AU - Lara Arellano SS AD - Facultad de Enfermeria, Universidad Veracruzana, Xalapa, Veracruz, Mexico. FAU - Meza, Jose Enrique AU - Meza JE AD - Centro de Investigaciones Biomedicas, Universidad Veracruzana, Xalapa, Veracruz, Mexico. FAU - Licona Cassani, Cuauhtemoc AU - Licona Cassani C AD - Departamento de Ingenieria Celular y Biocatalisis, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico. FAU - Viveros, Rubi AU - Viveros R AD - Centro de Investigaciones Biomedicas, Universidad Veracruzana, Xalapa, Veracruz, Mexico. LA - eng SI - figshare/10.6084/m9.figshare.30290248.v1 PT - Journal Article DEP - 20260603 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 RN - 0 (RNA, Ribosomal, 16S) SB - IM MH - Humans MH - Cross-Sectional Studies MH - Child, Preschool MH - Mexico MH - *Body Mass Index MH - Male MH - Female MH - *Feces/microbiology MH - *Gastrointestinal Microbiome MH - RNA, Ribosomal, 16S/genetics MH - Thinness/microbiology MH - Nutritional Status MH - Overweight/microbiology MH - Retrospective Studies PMC - PMC13242193 OTO - NOTNLM OT - Body mass index OT - Childhood OT - Clinical data OT - Gut microbiota OT - Nutritional status COIS- The authors declare there are no competing interests. EDAT- 2026/06/08 12:39 MHDA- 2026/06/11 18:36 PMCR- 2026/06/03 CRDT- 2026/06/08 07:25 PHST- 2025/10/15 00:00 [received] PHST- 2026/03/27 00:00 [accepted] PHST- 2026/06/11 18:36 [medline] PHST- 2026/06/08 12:39 [pubmed] PHST- 2026/06/08 07:25 [entrez] PHST- 2026/06/03 00:00 [pmc-release] AID - 21253 [pii] AID - 10.7717/peerj.21253 [doi] PST - epublish SO - PeerJ. 2026 Jun 3;14:e21253. doi: 10.7717/peerj.21253. eCollection 2026. PMID- 42254612 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Ontology-based dietary recommendation system for Chinese children and adolescents: development and a pilot validation study. PG - 1780898 LID - 10.3389/fpubh.2026.1780898 [doi] LID - 1780898 AB - BACKGROUND: Dietary imbalances among Chinese children and adolescents are prevalent, but most recommender systems are adult-oriented and not adapted to Chinese dietary patterns or school-family meal contexts. This study aims to developed and evaluated an ontology-based dietary recommendation system for Chinese children and adolescents to improve their dietary status. METHODS: An ontology knowledge base was constructed from dietary guidelines, expert knowledge, and food and meal data. A multi-criteria decision framework generated feasible meal plans, optimized portion sizes with a genetic algorithm, and selected solutions that promote food diversity. We conducted a preliminary evaluation of the system in two pilot settings: (1) a group-level experiment using 30 days of school lunch data from a primary school, and (2) an individual-level experiment using 30 days of dietary records and health check-up data from 30 middle school students. Diet quality was assessed using the Chinese Children Dietary Index (CCDI), nutrient adequacy rates, and food-group diversity. RESULTS: In the group experiment, system-recommended lunches achieved a significantly higher average CCDI score (117.39 +/- 6.61) than actual school lunches (103.41 +/- 9.44, p < 0.001). In the individual experiment, recommended full-day meals scored higher in CCDI (110.91 +/- 9.70) compared with self-selected diets (90.61 +/- 10.77, p < 0.001). Across both settings, the system reduced deficiencies in vegetables, fruits, and aquatic products with consistent improvements in nutrient adequacy and food diversity, while maintaining alignment with dietary guidelines. CONCLUSION: To the best of our knowledge, this study presents the first ontology-driven dietary recommendation system tailored for Chinese children and adolescents. By integrating structured knowledge representation with advanced decision-making algorithms, the system demonstrates promising improvements in dietary quality, nutritional balance, and food diversity across both school and family scenarios. These findings highlight the system's potential as a practical tool for promoting healthy eating behaviors, and informing nutrition education. CI - Copyright (c) 2026 Zhang, Xu, An, Yang, Xie and Deng. FAU - Zhang, Zhiyu AU - Zhang Z AD - College of Biomedical Engineering and Instrument Science, Ministry of Education Key Laboratory of Biomedical Engineering, Zhejiang University, Hangzhou, China. FAU - Xu, Dongdong AU - Xu D AD - College of Biomedical Engineering and Instrument Science, Ministry of Education Key Laboratory of Biomedical Engineering, Zhejiang University, Hangzhou, China. FAU - An, Jiye AU - An J AD - College of Biomedical Engineering and Instrument Science, Ministry of Education Key Laboratory of Biomedical Engineering, Zhejiang University, Hangzhou, China. FAU - Yang, Min AU - Yang M AD - Department of Nutrition and Food Hygiene, School of Public Health, Zhejiang University School of Medicine, Hangzhou, China. AD - Center of Clinical Big Data and Analytics, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. FAU - Xie, Sasa AU - Xie S AD - Department of Nutrition and Food Hygiene, School of Public Health, Zhejiang University School of Medicine, Hangzhou, China. AD - Center of Clinical Big Data and Analytics, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. FAU - Deng, Ning AU - Deng N AD - College of Biomedical Engineering and Instrument Science, Ministry of Education Key Laboratory of Biomedical Engineering, Zhejiang University, Hangzhou, China. AD - Binjiang Institute, Zhejiang University, Hangzhou, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260522 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - Chinese people SB - IM MH - Humans MH - Pilot Projects MH - Child MH - Adolescent MH - China MH - Female MH - Male MH - *Nutrition Policy MH - *Diet MH - Schools MH - Knowledge Bases MH - East Asian People PMC - PMC13236952 OTO - NOTNLM OT - artificial intelligence OT - children and adolescents OT - dietary recommendation OT - multi-criteria decision-making OT - ontology COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/08 12:38 MHDA- 2026/06/12 06:38 PMCR- 2026/05/22 CRDT- 2026/06/08 07:25 PHST- 2026/01/05 00:00 [received] PHST- 2026/05/01 00:00 [revised] PHST- 2026/05/04 00:00 [accepted] PHST- 2026/06/12 06:38 [medline] PHST- 2026/06/08 12:38 [pubmed] PHST- 2026/06/08 07:25 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1780898 [doi] PST - epublish SO - Front Public Health. 2026 May 22;14:1780898. doi: 10.3389/fpubh.2026.1780898. eCollection 2026. PMID- 42253746 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260608 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Serum BDNF as an integrative neuro-immunometabolic marker in adolescent polycystic ovary syndrome: divergent dietary and inflammatory associations across weight phenotypes. PG - 1830074 LID - 10.3389/fnut.2026.1830074 [doi] LID - 1830074 AB - BACKGROUND: Polycystic ovary syndrome (PCOS) in adolescence is characterized by hormonal imbalance, low-grade inflammation, oxidative stress, and metabolic dysfunction. Brain-derived neurotrophic factor (BDNF) regulates energy homeostasis and neuroimmune signaling and may act as a neuroimmunometabolic integrator in PCOS. METHODS: Forty adolescent females with PCOS (26 normal weight and 14 with overweight and obesity) were evaluated. Serum BDNF, omega-3 fatty acids (EPA, DHA), uric acid, metabolic and hormonal indices, and total antioxidant capacity (T-AOC) were measured. Dietary intake and physical activity were assessed using validated tools. RESULTS: Serum BDNF concentrations did not differ between BMI phenotypes. After FDR correction, significant dietary associations were observed only in normal-weight participants, including energy, protein, fat, and unsaturated fatty acids. No dietary associations remained significant in patients with overweight and obesity. Across both phenotypes, BDNF was positively associated with IL-1beta, MDA, T-AOC, EPA, and uric acid. IL-6, TNF-alpha, and DHA remained significant only in normal-weight participants. No associations were found with CRP, lipid profile, sex hormones, or glucose-insulin parameters. CONCLUSION: Circulating BDNF was associated with dietary, inflammatory, and oxidative parameters, with limited evidence for endocrine associations. These findings suggest that BDNF may reflect an integrated neuroimmunometabolic profile in adolescent PCOS and should be considered exploratory, requiring confirmation in longitudinal studies. CI - Copyright (c) 2026 Mizgier, Formanowicz, Sansoni, Jarzabek-Bielecka, Lombardi, Kedzia and Opydo-Szymaczek. FAU - Mizgier, Malgorzata AU - Mizgier M AD - Department of Sports Dietetics, Faculty of Health Sciences, Poznan University of Physical Education, Poznan, Poland. FAU - Formanowicz, Dorota AU - Formanowicz D AD - Chair and Department of Medical Chemistry and Laboratory Medicine, Poznan University of Medical Sciences, Poznan, Poland. FAU - Sansoni, Veronica AU - Sansoni V AD - Laboratory of Experimental Biochemistry and Advanced Diagnostics, I.R.C.C.S. Ospedale Galeazzi-Sant'Ambrogio, Milano, Italy. FAU - Jarzabek-Bielecka, Grazyna AU - Jarzabek-Bielecka G AD - Division of Gynecology, Department of Gynecology, Center of General Sexology and Sexology of Developmental Age, Poznan University of Medical Sciences, Poznan, Poland. FAU - Lombardi, Giovanni AU - Lombardi G AD - Laboratory of Experimental Biochemistry and Advanced Diagnostics, I.R.C.C.S. Ospedale Galeazzi-Sant'Ambrogio, Milano, Italy. AD - Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Poznan, Poland. FAU - Kedzia, Witold AU - Kedzia W AD - Division of Gynecology, Department of Gynecology, Center of General Sexology and Sexology of Developmental Age, Poznan University of Medical Sciences, Poznan, Poland. FAU - Opydo-Szymaczek, Justyna AU - Opydo-Szymaczek J AD - Department of Pediatric Dentistry, Poznan University of Medical Sciences, Poznan, Poland. LA - eng PT - Journal Article DEP - 20260521 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13233441 OTO - NOTNLM OT - BDNF OT - adolescence OT - antioxidant defence OT - diet OT - inflammation OT - insulin sensitivity OT - omega-3 fatty acids OT - oxidative stress COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author MM declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/06/08 12:38 MHDA- 2026/06/08 12:39 PMCR- 2026/05/21 CRDT- 2026/06/08 07:18 PHST- 2026/03/13 00:00 [received] PHST- 2026/04/17 00:00 [revised] PHST- 2026/04/24 00:00 [accepted] PHST- 2026/06/08 12:39 [medline] PHST- 2026/06/08 12:38 [pubmed] PHST- 2026/06/08 07:18 [entrez] PHST- 2026/05/21 00:00 [pmc-release] AID - 10.3389/fnut.2026.1830074 [doi] PST - epublish SO - Front Nutr. 2026 May 21;13:1830074. doi: 10.3389/fnut.2026.1830074. eCollection 2026. PMID- 42253219 OWN - NLM STAT- MEDLINE DCOM- 20261020 LR - 20261020 IS - 1467-1107 (Electronic) IS - 1047-9511 (Print) IS - 1047-9511 (Linking) VI - 36 IP - 6 DP - 2026 Jun TI - Assessment of improvements in exercise tolerance following pulmonary valve replacement using physical accelerometry. PG - 1208-1214 LID - 10.1017/S1047951126113493 [doi] AB - BACKGROUND: Pulmonary valve replacement may be required for patients with pulmonary valve disease. Exertional symptoms related to cardiovascular disease are an indication for pulmonary valve replacement; however, quantification of symptom improvement postoperatively is challenging, and previous studies have yielded mixed data. Accelerometry has the potential to remotely monitor changes in exercise tolerance following pulmonary valve replacement. METHODS: Individuals (n = 18) age >13 years scheduled for catheter-based or surgical pulmonary valve replacement were prospectively enrolled. Participants were instructed to wear two Link GT9X accelerometers, placed on dominant wrist and one ankle, for seven days and nights before pulmonary valve replacement and again 3-6 months after the procedure. RESULTS: The cohort's median age was 26.5 [16.0, 35.0] years old. Compliance of both wrist and ankle accelerometers had a median of 96% or greater at both timepoints suggesting adequate participation. Accelerometry showed stability between participants. Quantitative analysis using pre-and post-pulmonary valve replacement accelerometer-derived measures yielded no significant differences. There was a significant decrease in the average score for items "Shortness of Breath with Strenuous Activity," "Extent Symptoms Impact Daily Activities," and "Challenges with Activities of Daily Living." Furthermore, all 9 individuals with baseline exertional intolerance had resolution of symptom in postoperative assessment. CONCLUSION: Reliability of accelerometer-derived activity measurements supports usage of physical accelerometry as a remote outcome measure to reduce patient burden for onsite assessment. Mixed qualitative versus quantitative improvement in physical activity tolerance observed in this study aligns with previous studies on variable improvement in exercise tolerance following pulmonary valve replacement. This discrepancy suggests the need for a different quantitative mechanism to measure benefit. FAU - Joy, Nicholas AU - Joy N AUID- ORCID: 0009-0005-1400-797X AD - Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, USA. ROR: https://ror.org/05dq2gs74 FAU - Soslow, Jonathan H AU - Soslow JH AUID- ORCID: 0000-0001-9194-5330 AD - Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, USA. ROR: https://ror.org/05dq2gs74 FAU - Crum, Kimberly AU - Crum K AD - Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, USA. ROR: https://ror.org/05dq2gs74 FAU - Killian, Mary AU - Killian M AD - Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, USA. ROR: https://ror.org/05dq2gs74 AD - Division of Pediatric Cardiology, Department of Pediatrics, University of Louisville School of Medicine, USA. FAU - Sunthankar, Sudeep AU - Sunthankar S AUID- ORCID: 0000-0002-2687-8204 AD - Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, USA. ROR: https://ror.org/05dq2gs74 LA - eng GR - R01 HL167969/HL/NHLBI NIH HHS/United States GR - P50 HD106446/HD/NICHD NIH HHS/United States GR - R01 FD006649/FD/FDA HHS/United States GR - R56 HL141248/HL/NHLBI NIH HHS/United States GR - K23 HL123938/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20260608 PL - England TA - Cardiol Young JT - Cardiology in the young JID - 9200019 SB - IM MH - Humans MH - *Exercise Tolerance/physiology MH - Female MH - Male MH - *Accelerometry/methods MH - *Heart Valve Prosthesis Implantation MH - *Pulmonary Valve/surgery MH - Adult MH - Prospective Studies MH - Adolescent MH - Young Adult PMC - PMC13311448 MID - NIHMS2175068 OTO - NOTNLM OT - accelerometry OT - exercise tolerance OT - pulmonary valve replacement OT - tetralogy of Fallot COIS- Dr Soslow has received a grant from Ametris, LLC. to conduct an observational study, however no associated data was used in development of this manuscript. EDAT- 2026/06/08 12:38 MHDA- 2026/10/20 17:34 PMCR- 2026/06/29 CRDT- 2026/06/08 06:43 PHST- 2026/10/20 17:34 [medline] PHST- 2026/06/08 12:38 [pubmed] PHST- 2026/06/08 06:43 [entrez] PHST- 2026/06/29 00:00 [pmc-release] AID - S1047951126113493 [pii] AID - 10.1017/S1047951126113493 [doi] PST - ppublish SO - Cardiol Young. 2026 Jun;36(6):1208-1214. doi: 10.1017/S1047951126113493. Epub 2026 Jun 8. PMID- 42252390 OWN - NLM STAT- MEDLINE DCOM- 20260812 LR - 20260814 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Jun 8 TI - Construction and validation of interpersonal violence in terms of the hot weather scale for university students. LID - 10.1186/s40359-026-04929-0 [doi] LID - 1179 AB - The development and validation of interpersonal violence in terms of hot weather scale is the goal of the current study. The initial pool of items was developed by reviewing the literature and taking into account the results of semi-structured interviews (inductive & deductive approach). After expert opinion and ensuring content validity, 25 Items were finalized for further analysis. To run an exploratory factor analysis, data were collected from 1,000 university students. EFA revealed a unidimensional factor structure with 16 retained items, explaining 80.2% of the variance. The scale's 0.98 Cronbach's alpha demonstrates a good level of internal consistency. Confirmatory factor analysis confirmed a unidimensional factor structure with 16 items retained on an independent sample of 350 university students. Convergent and divergent validity of the scale was assessed through an independent sample (n = 440). The results showed that there was a strong positive relationship of interpersonal violence in terms of hot weather, with aggression, and a non-significant relationship with eating behavior. The scale can be regarded as a psychometrically reliable tool to assess interpersonal violence in terms of hot weather. CI - (c) 2026. The Author(s). FAU - Ghayas, Saba AU - Ghayas S AD - Department of Psychology, University of Sargodha, Sargodha, Pakistan. saba.ghayas@uos.edu.pk. FAU - Varrasi, Simone AU - Varrasi S AD - Department of Educational Sciences, University of Catania, Via Teatro Greco 84, Catania, 95124, Italy. FAU - Platania, Giuseppe Alessio AU - Platania GA AD - Department of Educational Sciences, University of Catania, Via Teatro Greco 84, Catania, 95124, Italy. FAU - Guerrera, Claudia Savia AU - Guerrera CS AD - Department of Educational Sciences, University of Catania, Via Teatro Greco 84, Catania, 95124, Italy. FAU - Boccaccio, Francesco Maria AU - Boccaccio FM AD - Department of Educational Sciences, University of Catania, Via Teatro Greco 84, Catania, 95124, Italy. FAU - Torre, Vittoria AU - Torre V AD - Department of Educational Sciences, University of Catania, Via Teatro Greco 84, Catania, 95124, Italy. FAU - Pirrone, Concetta AU - Pirrone C AD - Department of Educational Sciences, University of Catania, Via Teatro Greco 84, Catania, 95124, Italy. FAU - Coco, Emanuele AU - Coco E AD - Department of Educational Sciences, University of Catania, Via Teatro Greco 84, Catania, 95124, Italy. FAU - Castellano, Sabrina AU - Castellano S AD - Department of Educational Sciences, University of Catania, Via Teatro Greco 84, Catania, 95124, Italy. FAU - Ferraioli, Francesca AU - Ferraioli F AD - Laboratory of Cognitive and Social Neuroscience, Department of Cognitive Science, Psychology, Education and Cultural Studies (COSPECS), University of Messina, Messina, Italy. FAU - Massimino, Simona AU - Massimino S AD - Laboratory of Cognitive and Social Neuroscience, Department of Cognitive Science, Psychology, Education and Cultural Studies (COSPECS), University of Messina, Messina, Italy. FAU - Mahar, Amama AU - Mahar A AD - Department of Psychology, University of Sargodha, Sargodha, Pakistan. FAU - Akmal, Rashida AU - Akmal R AD - Department of Psychology, University of Sargodha, Sargodha, Pakistan. LA - eng PT - Journal Article PT - Validation Study DEP - 20260608 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - *Psychometrics/instrumentation MH - *Students/psychology MH - Female MH - Universities MH - Reproducibility of Results MH - Young Adult MH - Male MH - *Violence/psychology MH - *Interpersonal Relations MH - Adult MH - Factor Analysis, Statistical MH - *Weather MH - Aggression/psychology MH - Surveys and Questionnaires MH - Adolescent MH - *Hot Temperature PMC - PMC13466488 OTO - NOTNLM OT - Confirmatory factor analysis OT - Exploratory factor analysis OT - Hot weather OT - Interpersonal violence OT - Psychometric properties OT - Scale development COIS- Declarations. Ethics approval and consent to participate: The research process was planned and executed in accordance with the Declaration of Helsinki. Ethical approval was taken from the IRB, University of Sargodha (IRB 22/ 2023). Moreover, the topic was also reviewed by the departmental ethical committee, Department of Educational Science, University of Catania, Italy. Lastly, Written informed consent was taken from participants. Consent for publication: NA. Competing interests: The authors declare no competing interests. EDAT- 2026/06/08 00:35 MHDA- 2026/08/12 06:05 PMCR- 2026/06/08 CRDT- 2026/06/07 23:23 PHST- 2025/10/07 00:00 [received] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/08/12 06:05 [medline] PHST- 2026/06/08 00:35 [pubmed] PHST- 2026/06/07 23:23 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - 10.1186/s40359-026-04929-0 [pii] AID - 4929 [pii] AID - 10.1186/s40359-026-04929-0 [doi] PST - epublish SO - BMC Psychol. 2026 Jun 8;14(1):1179. doi: 10.1186/s40359-026-04929-0. PMID- 42251514 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260611 IS - 0975-4466 (Electronic) IS - 0256-4947 (Linking) VI - 46 IP - 3 DP - 2026 May-Jun TI - Establishment and validation of reference intervals for the neutrophil CD64 index in a healthy adult population from Guangxi, China. PG - 216-224 LID - 10.5144/0256-4947.2026.216 [doi] AB - BACKGROUND: The neutrophil CD64 (nCD64) index is a potent biomarker for infectious diseases; however, the lack of standardized reference intervals (RIs) limits its clinical utility. OBJECTIVES: This study aimed to establish and validate reference intervals (RIs) for the nCD64 index specifically for the Guangxi population using flow cytometry. DESIGN: Cross-sectional study. SETTINGS: Conducted in Guangxi, China. PATIENTS AND METHODS: A total of 494 healthy adults (aged 18-83 years) were enrolled. Peripheral blood nCD64 expression was measured via flow cytometry. Reference intervals were determined using the non-parametric 95th percentile method (2.5th-97.5th) per CLSI EP28-A3c guidelines. Validation was performed in an independent cohort (n=30). MAIN OUTCOME MEASURES: The primary outcome was the 95% reference interval for the nCD64 index. Secondary outcomes included correlations between nCD64 index and sex, age, BMI, and primary hematological parameters. SAMPLE SIZE: 494 healthy adults for establishment, plus 30 independent subjects for validation. RESULTS: No clinically significant differences in the nCD64 index were found between sexes or across age groups, and partitioning was not required. The nCD64 index exhibited a skewed distribution. Although sex showed a weak positive correlation with nCD64 expression (r=.115, P=.011), the standard normal deviation test (z/=108 degrees (sensitivity 95.24%, specificity 93.15%). Stratified analysis confirmed the therapeutic superiority of Abbe flap was independent of initial cleft type, and preoperative lip height index (LHI) and intercanthal width to medial upper lip height ratio (IMWH) were independent predictors for optimal postoperative outcomes. CONCLUSION: Preoperative ULR /=108 degrees can be used as preliminary objective quantitative reference criteria for Abbe flap selection in secondary cleft lip deformity patients, with prospective multi-center validation required for further clinical generalization. The Abbe flap can achieve significant correction of morphological abnormalities caused by upper lip tissue deficiency, and preoperative LHI and IMWH can assist in prognostic evaluation for surgical candidates. CI - Copyright (c) 2026 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - He, Wen AU - He W AD - Department of Burn and Plastic Surgery, Children's Hospital of Chongqing Medical University, No. 136 Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China. Electronic address: 1738591282@qq.com. FAU - Qiu, Lin AU - Qiu L AD - Department of Burn and Plastic Surgery, Children's Hospital of Chongqing Medical University, No. 136 Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China. LA - eng PT - Journal Article DEP - 20260529 PL - Netherlands TA - J Plast Reconstr Aesthet Surg JT - Journal of plastic, reconstructive & aesthetic surgery : JPRAS JID - 101264239 SB - IM MH - Humans MH - *Cleft Lip/surgery MH - *Surgical Flaps MH - Female MH - Retrospective Studies MH - Male MH - Treatment Outcome MH - *Plastic Surgery Procedures/methods MH - Child MH - Child, Preschool MH - Lip/surgery MH - Adolescent MH - Infant OTO - NOTNLM OT - Abbe flap OT - Anthropometric measurement OT - Quantitative indication OT - Secondary cleft lip deformity OT - Surgical outcome COIS- Declaration of Competing Interest None declared. EDAT- 2026/06/06 00:34 MHDA- 2026/06/27 00:53 CRDT- 2026/06/05 18:03 PHST- 2026/04/01 00:00 [received] PHST- 2026/05/24 00:00 [revised] PHST- 2026/05/26 00:00 [accepted] PHST- 2026/06/27 00:53 [medline] PHST- 2026/06/06 00:34 [pubmed] PHST- 2026/06/05 18:03 [entrez] AID - S1748-6815(26)00316-5 [pii] AID - 10.1016/j.bjps.2026.05.050 [doi] PST - ppublish SO - J Plast Reconstr Aesthet Surg. 2026 Jul;118:313-324. doi: 10.1016/j.bjps.2026.05.050. Epub 2026 May 29. PMID- 42247658 OWN - NLM STAT- MEDLINE DCOM- 20260610 LR - 20260908 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Jun 5 TI - Screen-Free Time With Friends to Promote Face-to-Face Peer Interaction and Reduce Recreational Screen Use Among Children Aged 9-11 Years: Protocol for a Cluster Randomized Controlled Trial. PG - e84831 LID - 10.2196/84831 [doi] LID - e84831 AB - BACKGROUND: Children's leisure time has changed in recent decades-with more time spent on screen media and less time face-to-face with peers-potentially affecting their physical and mental well-being. OBJECTIVE: This protocol outlines a cluster randomized controlled trial evaluating the Screen-Free Time With Friends intervention, which aims to promote face-to-face peer interaction and reduce recreational screen media use among children aged 9-11 years. METHODS: The study is conducted as a cluster randomized controlled trial involving 9-11-year-old children and their parents from 18 schools in Denmark. Schools are randomized (1:1) to either a control or an intervention group. The intervention includes five core components: (1) curricular activities, (2) two family meetings, (3) a brief parent exercise, (4) a development program for after-school clubs, and (5) two community workshops. It is designed to allow local adaptation while maintaining fidelity to the core components. Primary and key secondary outcomes, including face-to-face peer interaction across leisure domains and solitary screen time, are assessed at baseline, 6-10 months, and 13-15 months follow-up. Additional exploratory outcomes (e.g., leisure activities, social relations, and well-being) are measured at baseline and follow-up. Time spent in face-to-face interactions with peers was assessed using a short SMS-based questionnaire sent to registered parents. The instrument has not been formally validated but was tested in a feasibility study. A comprehensive process evaluation explores implementation, context, and mechanisms of change. RESULTS: The project was funded in July 2020. Schools were recruited from July 2023 to January 2024, while children and parents were recruited from November 2023 to April 2024. At baseline, 685 children were enrolled at the participating schools, with 343 (50%) having at least one parent enrolled in the questionnaire. The primary outcome is therefore assessed among a subset of participants, which may affect the effective sample size. Baseline data were collected from December 2023 to June 2024, and follow-up data from March to August 2025. As of March 2026, data analysis has not yet commenced, and no study results are currently available. Findings are expected to be published by the end of 2026. CONCLUSIONS: Regardless of the findings, this study will generate important knowledge about the intervention's potential effectiveness, complemented by insights into its implementation, context, and mechanisms of change. These insights can assist municipalities, schools, after-school clubs, community stakeholders, and parents in shaping everyday environments that foster children's face-to-face interaction and encourage balanced screen use. The findings may inform policy decisions, guide the development of new national and local initiatives, and inspire future research into feasible, real-world interventions that support meaningful and enriching leisure experiences for children. CI - (c) Sara Kruse Lange, Sarah Overgaard Slater, Teresa Victoria Hoy, Kristian Traberg Larsen, Anders Blaedel Gottlieb Hansen, Russell Jago, Peter Lund Kristensen, Anders Grontved, Mette Toftager, Anne Kaer Gejl. Originally published in JMIR Research Protocols (https://www.researchprotocols.org). FAU - Lange, Sara Kruse AU - Lange SK AUID- ORCID: 0009-0003-6477-2325 AD - Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, Odense, 5230, Denmark, 45 65507908. FAU - Sorensen, Sarah Overgaard AU - Sorensen SO AUID- ORCID: 0000-0002-3953-3387 AD - Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, Odense, 5230, Denmark, 45 65507908. FAU - Hoy, Teresa Victoria AU - Hoy TV AUID- ORCID: 0000-0002-2452-1535 AD - National Institute of Public Health, Faculty of Health Sciences, University of Southern Denmark, Copenhagen, Denmark. FAU - Larsen, Kristian Traberg AU - Larsen KT AUID- ORCID: 0000-0002-3918-6645 AD - Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, Odense, 5230, Denmark, 45 65507908. FAU - Hansen, Anders Blaedel Gottlieb AU - Hansen ABG AUID- ORCID: 0000-0001-6777-2257 AD - Center for Clinical Research and Prevention, Copenhagen University Hospital, Frederiksberg, Denmark. FAU - Jago, Russell AU - Jago R AUID- ORCID: 0000-0002-3394-0176 AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom. FAU - Kristensen, Peter Lund AU - Kristensen PL AUID- ORCID: 0000-0002-5666-9614 AD - Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, Odense, 5230, Denmark, 45 65507908. FAU - Grontved, Anders AU - Grontved A AUID- ORCID: 0000-0003-1584-679X AD - Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, Odense, 5230, Denmark, 45 65507908. FAU - Toftager, Mette AU - Toftager M AUID- ORCID: 0000-0002-6736-3725 AD - Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, Odense, 5230, Denmark, 45 65507908. FAU - Gejl, Anne Kaer AU - Gejl AK AUID- ORCID: 0000-0001-6781-2263 AD - Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, Odense, 5230, Denmark, 45 65507908. LA - eng SI - ClinicalTrials.gov/NCT06163495 PT - Clinical Trial Protocol PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260605 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Child MH - Female MH - Humans MH - Male MH - Denmark MH - *Friends/psychology MH - Interpersonal Relations MH - Leisure Activities MH - *Peer Group MH - *Screen Time MH - Surveys and Questionnaires MH - Randomized Controlled Trials as Topic PMC - PMC13240986 OTO - NOTNLM OT - after-school programs OT - child OT - community participation OT - digital media use OT - interpersonal relations OT - mental health OT - physical activity OT - screen time OT - social interaction OT - well-being COIS- Conflicts of Interest: None declared. EDAT- 2026/06/05 18:36 MHDA- 2026/06/11 05:42 PMCR- 2026/06/05 CRDT- 2026/06/05 16:12 PHST- 2025/09/26 00:00 [received] PHST- 2026/03/30 00:00 [revised] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/06/11 05:42 [medline] PHST- 2026/06/05 18:36 [pubmed] PHST- 2026/06/05 16:12 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - v15i1e84831 [pii] AID - 84831 [pii] AID - 10.2196/84831 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Jun 5;15:e84831. doi: 10.2196/84831. PMID- 42246427 OWN - NLM STAT- MEDLINE DCOM- 20260917 LR - 20260917 IS - 1525-6073 (Electronic) IS - 0742-0528 (Linking) VI - 43 IP - 10 DP - 2026 Oct TI - L5 onset as a proxy for circadian phase in infants. PG - 1518-1523 LID - 10.1080/07420528.2026.2681616 [doi] AB - Chronotype is commonly assessed using the mid-sleep point as an indicator of circadian phase. In infants, however, this assessment typically relies on actigraphy, and most available sleep-scoring algorithms have been developed and validated for adolescents and adults, limiting their applicability in early childhood. The aim of this study was to examine the relationship between the mid-sleep point and L5 onset, a nonparametric measure derived from rest-activity rhythms that reflects the start of the least active 5-h period. A total of 502 nights from 81 six-month-old infants were analyzed. Sleep onset and offset were determined by visual inspection of actograms, and the mid-sleep point was subsequently calculated. A positive correlation was observed between mid-sleep point and L5 onset (r = 0.22, p < 0.001). Linear mixed-effects models indicated significant associations both between infants (beta = 0.63, p < 0.001) and within infants (beta = 0.10, p < 0.001). These findings suggest that L5 onset may serve as a practical proxy for circadian phase in 6-month-old infants, offering an alternative to sleep parameters derived from algorithms not specifically validated for this age group. FAU - Buest de Mesquita Silva, Rebeca AU - Buest de Mesquita Silva R AUID- ORCID: 0000-0002-8288-7391 AD - Physiology Department, Federal University of Parana, Curitiba, Brazil. FAU - Holler Pykocz, Adrielle AU - Holler Pykocz A AUID- ORCID: 0009-0008-7761-6176 AD - Physiology Department, Federal University of Parana, Curitiba, Brazil. FAU - Victoria Leal, Hanna AU - Victoria Leal H AD - Physiology Department, Federal University of Parana, Curitiba, Brazil. FAU - Leocadio-Miguel, Mario Andre AU - Leocadio-Miguel MA AUID- ORCID: 0000-0002-7248-3529 AD - School of Psychology, Northumbria University, Newcastle Upon Tyne, UK. FAU - Louzada, Fernando Mazzilli AU - Louzada FM AUID- ORCID: 0000-0002-4982-8082 AD - Physiology Department, Federal University of Parana, Curitiba, Brazil. FAU - Group, Cpapi AU - Group C AD - Brazilian Center for Early Childhood Development, Insper, Sao Paulo, Brazil. LA - eng PT - Journal Article DEP - 20260605 PL - England TA - Chronobiol Int JT - Chronobiology international JID - 8501362 SB - IM MH - Humans MH - Infant MH - *Circadian Rhythm/physiology MH - *Sleep/physiology MH - Female MH - Male MH - Actigraphy MH - Chronotype MH - Algorithms OTO - NOTNLM OT - L5 onset OT - circadian phase OT - infant sleep OT - mid-sleep point EDAT- 2026/06/05 12:41 MHDA- 2026/09/17 15:36 CRDT- 2026/06/05 07:34 PHST- 2026/09/17 15:36 [medline] PHST- 2026/06/05 12:41 [pubmed] PHST- 2026/06/05 07:34 [entrez] AID - 10.1080/07420528.2026.2681616 [doi] PST - ppublish SO - Chronobiol Int. 2026 Oct;43(10):1518-1523. doi: 10.1080/07420528.2026.2681616. Epub 2026 Jun 5. PMID- 42245835 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260605 LR - 20260813 IS - 1664-042X (Print) IS - 1664-042X (Electronic) IS - 1664-042X (Linking) VI - 17 DP - 2026 TI - Sex-specific BMI, 24-hour movement behaviors, motor skills, and executive functions in Tunisian preschool children: an observational cross-sectional study. PG - 1853244 LID - 10.3389/fphys.2026.1853244 [doi] LID - 1853244 AB - BACKGROUND: Early childhood is a critical period for motor, cognitive, and behavioral development, and the rising prevalence of overweight and obesity are associated with differences in physical activity (PA), motor skills (MS), and executive functions (EF). This study aimed to examine associations between sex-specific BMI categories, 24-hour movement behaviors (MB), MS, and EF in Tunisian preschool children. METHODS: A cross-sectional observational study included 112 children aged 4-5 years (50 boys, 62 girls) from urban and rural kindergartens. Anthropometric measures classified children into sex-specific BMI categories (below normal, normal, above normal). PA, sedentary behavior (SB), and sleep were objectively assessed via accelerometry over five consecutive days. EF (inhibition, working memory) and MS (functional mobility, balance, upper and lower limb strength, manual dexterity) were evaluated using standardized and validated tests. RESULTS: Overall, BMI showed limited associations with MB, EF, and MS, but some sex-specific associations were observed. Statistically significant differences were found for upper-body strength (girls, p = 0.003), moderate intensity PA (girls, p = 0.040), and screen-based SB (boys, p = 0.049). No statistically significant differences were observed for functional mobility, balance, lower limb strength, manual dexterity, other PA measures, sleep, or EF. Anthropometric scores were higher in BMI > normal groups, most children met MVPA and sleep recommendations, but total PA compliance was low. CONCLUSION: This study provides novel evidence from a North African context on sex-specific associations between BMI, MB, MS, and EF in preschool children. Findings indicate limited but domain-specific functional implications of BMI and emphasize the need for longitudinal, sex-stratified studies with larger samples to clarify developmental trajectories. However, due to the cross-sectional design, these findings reflect associations only, and no causal inferences can be drawn from these results. CI - Copyright (c) 2026 Meksi, Ltifi, Alfawaz, Alotaibi and Chelly. FAU - Meksi, Sonia AU - Meksi S AD - Research Laboratory (LR23JS01), Sport Performance, Health & Society, Higher Institute of Sport and Physical Education of Ksar Said, University of Manouba, Tunis, Tunisia. FAU - Ltifi, Mohamed Amine AU - Ltifi MA AD - Research Laboratory (LR23JS01), Sport Performance, Health & Society, Higher Institute of Sport and Physical Education of Ksar Said, University of Manouba, Tunis, Tunisia. AD - University of Gafsa, Higher Institute of Sport and Physical Education of Gafsa, Gafsa, Tunisia. FAU - Alfawaz, Waad AU - Alfawaz W AD - Community Health Sciences Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia. FAU - Alotaibi, Abdulazeem AU - Alotaibi A AD - Department of Physical Education and Kinesiology, College of Education, Qassim University, Qassim, Saudi Arabia. FAU - Chelly, Mohamed Souhaiel AU - Chelly MS AD - Research Laboratory (LR23JS01), Sport Performance, Health & Society, Higher Institute of Sport and Physical Education of Ksar Said, University of Manouba, Tunis, Tunisia. LA - eng PT - Journal Article DEP - 20260520 PL - Switzerland TA - Front Physiol JT - Frontiers in physiology JID - 101549006 PMC - PMC13229776 OTO - NOTNLM OT - 24-hour movement behaviors OT - BMI OT - North Africa OT - executive functions OT - motor skills OT - observational study OT - preschool children COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor SH declared a past co-authorship with the author ML. The author MSC declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/06/05 06:36 MHDA- 2026/06/05 06:37 PMCR- 2026/05/20 CRDT- 2026/06/05 05:08 PHST- 2026/04/11 00:00 [received] PHST- 2026/05/01 00:00 [revised] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/06/05 06:37 [medline] PHST- 2026/06/05 06:36 [pubmed] PHST- 2026/06/05 05:08 [entrez] PHST- 2026/05/20 00:00 [pmc-release] AID - 10.3389/fphys.2026.1853244 [doi] PST - epublish SO - Front Physiol. 2026 May 20;17:1853244. doi: 10.3389/fphys.2026.1853244. eCollection 2026. PMID- 42245271 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260605 LR - 20260813 IS - 1178-7007 (Print) IS - 1178-7007 (Electronic) IS - 1178-7007 (Linking) VI - 19 DP - 2026 TI - Plasma Melanin-Concentrating Hormone in Childhood Obesity and Its Association with Metabolic Parameters: A Clinical Observational Study. PG - 590517 LID - 10.2147/DMSO.S590517 [doi] LID - 590517 AB - INTRODUCTION: Obesity is a global public health problem associated with complex neuroendocrine dysregulation. Melanin-concentrating hormone (MCH), a hypothalamic regulator of energy balance, promotes appetite and positive energy balance and has been linked to metabolic disturbances in adults. However, its clinical relevance in childhood obesity, where neuroendocrine alterations may precede overt metabolic complications, remains insufficiently characterized. AIM: This study aimed to determine whether plasma MCH levels are associated with metabolic alterations in children and adolescents with obesity. METHODS: In this clinical observational study, 283 participants were classified according to World Health Organization BMI-for-age criteria into obese and normal-weight groups. Plasma MCH concentrations were measured using a validated high-sensitivity radioimmunoassay (analytical detection limit: 0.2 fmol/mL). Anthropometric parameters, glucose-insulin homeostasis markers (glucose, insulin, C-peptide, HOMA-IR), lipid profile, thyroid hormones, and liver enzymes were assessed. Associations were analyzed using Spearman correlation after non-parametric distribution testing. RESULTS: Plasma MCH exhibited limited and selective associations with metabolic parameters in obese children and adolescents. Modest correlations were observed within the glucose-insulin and thyroid-related domains, whereas associations with lipid profile measures were weak or inverse. These patterns suggest age-dependent neuroendocrine involvement in pediatric obesity. CONCLUSION: Elevated plasma MCH levels in childhood obesity are associated with selective neuroendocrine and metabolic alterations rather than overt dyslipidemia. In view of the cross-sectional design and modest effect sizes, these findings should be considered exploratory and require confirmation in longitudinal pediatric studies. CI - (c) 2026 Leiter et al. FAU - Leiter, Imre AU - Leiter I AD - Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Lelesz, Beata AU - Lelesz B AUID- ORCID: 0009-0001-4922-7359 AD - Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Hegedus, Csaba AU - Hegedus C AUID- ORCID: 0000-0001-8067-2701 AD - Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Nemeth, Jozsef AU - Nemeth J AD - Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Pelles-Tasko, Beata AU - Pelles-Tasko B AD - Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Ujlaki, Gyula AU - Ujlaki G AUID- ORCID: 0000-0001-8376-3940 AD - Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Bhattoa, Harjit Pal AU - Bhattoa HP AD - Institute of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Felszeghy, Eniko Noemi AU - Felszeghy EN AD - Institute of Pediatrics, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Lengyel, Szabolcs AU - Lengyel S AD - Department of Clinical Pharmacology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Pall, Denes AU - Pall D AD - Department of Clinical Pharmacology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Balla, Gyorgy AU - Balla G AD - Institute of Pediatrics, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Szilvassy, Zoltan AU - Szilvassy Z AD - Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Juhasz, Bela AU - Juhasz B AD - Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Kiss, Rita AU - Kiss R AUID- ORCID: 0000-0003-1208-366X AD - Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. LA - eng PT - Journal Article DEP - 20260529 PL - New Zealand TA - Diabetes Metab Syndr Obes JT - Diabetes, metabolic syndrome and obesity : targets and therapy JID - 101515585 PMC - PMC13231885 OTO - NOTNLM OT - MCH OT - appetite regulation OT - energy homeostasis OT - insulin OT - juvenile obesity OT - neuropeptide signaling OT - radioimmunoassay COIS- The author(s) report no conflicts of interest in this work. EDAT- 2026/06/05 06:35 MHDA- 2026/06/05 06:36 PMCR- 2026/05/29 CRDT- 2026/06/05 05:02 PHST- 2026/01/01 00:00 [received] PHST- 2026/03/03 00:00 [accepted] PHST- 2026/06/05 06:36 [medline] PHST- 2026/06/05 06:35 [pubmed] PHST- 2026/06/05 05:02 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - 590517 [pii] AID - 10.2147/DMSO.S590517 [doi] PST - epublish SO - Diabetes Metab Syndr Obes. 2026 May 29;19:590517. doi: 10.2147/DMSO.S590517. eCollection 2026. PMID- 42245268 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260605 LR - 20260813 IS - 1178-7007 (Print) IS - 1178-7007 (Electronic) IS - 1178-7007 (Linking) VI - 19 DP - 2026 TI - Body Appreciation and Weight Control Behaviors in Overweight Adolescents: A Cross-Sectional Study Informing a CBT-Based Health Promotion Model. PG - 594983 LID - 10.2147/DMSO.S594983 [doi] LID - 594983 AB - BACKGROUND: Overweight and obesity in adolescents have become significant public health issues, with traditional interventions showing limited effectiveness. Cognitive behavioral therapy (CBT) offers a novel approach to adolescent health promotion by altering individuals' cognitive and behavioral patterns. OBJECTIVE: This study was designed to construct a health behavior promotion model for overweight adolescents integrating CBT theory and to empirically validate it based on multidimensional behavioral scoring. METHODS: A cross-sectional study was conducted among 294 adolescents aged 13-16 from three secondary schools. Participants were classified into overweight/obese (n = 86) and normal weight (n = 208) groups based on BMI criteria. Data were collected using the Body Appreciation Scale-2, Weight Control Practices Questionnaire, and Comprehensive Lifestyle Assessment Scale. Statistical analyses included independent t-tests, Pearson correlation, structural equation modeling (SEM), and multiple regression. RESULTS: Overweight adolescents scored significantly lower in body appreciation cognition (t = 4.32, p < 0.001) and healthy weight control behaviors (t = 3.87, p < 0.001), and higher in unhealthy weight control behaviors (t = 4.96, p < 0.001). SEM revealed that body appreciation cognition had a direct negative effect on BMI (beta = -0.18, p < 0.01) and an indirect effect through healthy weight control behaviors (beta = -0.12, p < 0.05). The model demonstrated good fit (chi(2)/df = 2.36, CFI = 0.94, RMSEA = 0.06). CONCLUSION: The findings support the applicability of a CBT-based health behavior promotion model for overweight adolescents. The model, encompassing cognitive restructuring, behavioral activation, self-monitoring, and relapse prevention, provides a theoretical foundation for school- and community-based interventions. CI - (c) 2026 Wu et al. FAU - Wu, Xiaoqiu AU - Wu X AD - Department of Nursing, The Second Hospital of Jinhua, Jinhua, 321016, People's Republic of China. FAU - Xu, Qunying AU - Xu Q AD - Department of Supervision Ward, The Second Hospital of Jinhua, Jinhua, 321016, People's Republic of China. FAU - Wu, Zhen AU - Wu Z AD - Department of Nursing, The Second Hospital of Jinhua, Jinhua, 321016, People's Republic of China. FAU - Zheng, Lanzhen AU - Zheng L AD - Department of Nursing, The Second Hospital of Jinhua, Jinhua, 321016, People's Republic of China. LA - eng PT - Journal Article DEP - 20260529 PL - New Zealand TA - Diabetes Metab Syndr Obes JT - Diabetes, metabolic syndrome and obesity : targets and therapy JID - 101515585 PMC - PMC13231876 OTO - NOTNLM OT - adolescents OT - behavioral intervention OT - cognitive behavioral therapy OT - health behaviors OT - overweight COIS- All of the authors had no any personal, financial, commercial, or academic conflicts of interest separately. EDAT- 2026/06/05 06:36 MHDA- 2026/06/05 06:37 PMCR- 2026/05/29 CRDT- 2026/06/05 05:02 PHST- 2026/01/15 00:00 [received] PHST- 2026/03/26 00:00 [accepted] PHST- 2026/06/05 06:37 [medline] PHST- 2026/06/05 06:36 [pubmed] PHST- 2026/06/05 05:02 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - 594983 [pii] AID - 10.2147/DMSO.S594983 [doi] PST - epublish SO - Diabetes Metab Syndr Obes. 2026 May 29;19:594983. doi: 10.2147/DMSO.S594983. eCollection 2026. PMID- 42244362 OWN - NLM STAT- Publisher LR - 20260622 IS - 1475-2662 (Electronic) IS - 0007-1145 (Linking) DP - 2026 Jun 5 TI - Association of lifestyle behaviours and socio-economic disparities with overweight and obesity among school-aged children and adolescents: a population-based cross-sectional study. PG - 1-14 LID - 10.1017/S0007114526107715 [doi] AB - This population-based cross-sectional study investigated the associations of sleep, nutrition and physical activity with overweight and obesity among 4108 school-aged children and adolescents (9-17 years) in Punjab, Pakistan, alongside 3371 parental responses. BMI was calculated using anthropometric measurements, and weight status was classified according to the 2007 WHO growth reference. Socio-economic status was determined through parental education, occupation and household income, while lifestyle behaviours were assessed via validated questionnaires. Multivariate logistic regression analyses were conducted, adjusting for sex, grade and socio-economic variables. The prevalence of overweight and obesity was 19.4 % and 10.7 %, respectively. Girls had a higher obesity prevalence than boys (12.3 % v. 8.9 %), whereas boys showed a higher combined prevalence of overweight and obesity. Among boys, obesity was significantly associated with urban residence (adjusted OR (aOR) 1.37; 95 % CI 1.13, 1.83), being an only child (aOR 2.74; 95 % CI 1.92, 3.92), frequent fast-food consumption (>/= 3 times/week; aOR 1.56; 95 % CI 1.23, 1.97) and lower parental education (aOR 1.22; 95 % CI 1.05, 1.41). Among girls, long weekend sleep duration increased obesity risk (aOR 1.38; 95 % CI 1.14, 1.67), while being an only child (aOR 0.36; 95 % CI 0.25, 0.52), frequent fast-food consumption (aOR 0.64; 95 % CI 0.50, 0.80) and lower parental education (aOR 0.81; 95 % CI 0.70, 0.94) were linked to lower odds. Physical activity and soft drink intake were not significant after adjustment. These findings underscore complex, gender-specific relationships between lifestyle and socio-economic factors, highlighting the need for targeted interventions promoting healthy sleep, nutrition and equity-focused strategies. FAU - Tanveer, Moazzam AU - Tanveer M AD - School of Physical Education and Sport Training, https://ror.org/0056pyw12Shanghai University of Sport, Shanghai, People's Republic of China. AD - Department of Allied Health Sciences, https://ror.org/02a37xs76Health Services Academy, Islamabad, Pakistan. AD - School of Health Professionals' Education Research & Entrepreneurship, https://ror.org/02a37xs76Health Services Academy, Islamabad, Pakistan. FAU - Alsabih, Ahmed Othman AU - Alsabih AO AD - Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. FAU - Cai, Yujun AU - Cai Y AD - School of Physical Education and Sport Training, https://ror.org/0056pyw12Shanghai University of Sport, Shanghai, People's Republic of China. FAU - Alsharidah, Ashwag Saleh AU - Alsharidah AS AD - Department of Physiology, College of Medicine, Qassim University, Buraydah, Saudi Arabia. FAU - Badicu, Georgian AU - Badicu G AD - Department of Physical Education and Special Motricity, Faculty of Physical Education and Mountain Sports, Transilvania University of Brasov, Brasov, Romania. FAU - Asghar, Ejaz AU - Asghar E AD - Department of Allied Health Sciences, https://ror.org/02a37xs76Health Services Academy, Islamabad, Pakistan. AD - School of Health Professionals' Education Research & Entrepreneurship, https://ror.org/02a37xs76Health Services Academy, Islamabad, Pakistan. FAU - Tanveer, Umar AU - Tanveer U AD - School of Allied Health Sciences, The University of Lahore, Lahore, Pakistan. FAU - Roy, Nadeem AU - Roy N AD - School of Physical Education, Shanxi University, Taiyuan, People's Republic of China. FAU - Albaridi, Najla A AU - Albaridi NA AD - Department of Health Science, College of Health and Rehabilitation, Princess Noura bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Alsharari, Zayed D AU - Alsharari ZD AD - Department of Health Rehabilitation Sciences, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia. FAU - Saraiva, Ariana AU - Saraiva A AD - Research in Veterinary Medicine (I-MVET), Faculty of Veterinary Medicine, Lisbon University Centre, Lusofona University, Lisboa, Portugal. AD - Veterinary and Animal Research Centre (CECAV), Faculty of Veterinary Medicine, Lisbon University Centre, Lusofona University, Lisboa, Portugal. FAU - Raposo, Antonio AU - Raposo A AUID- ORCID: 0000-0002-5286-2249 AD - CBIOS (Research Center for Biosciences and Health Technologies), ECTS (School of Health Sciences and Technologies), https://ror.org/05xxfer42Lusofona University, Lisboa, Portugal. LA - eng PT - Journal Article DEP - 20260605 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM OTO - NOTNLM OT - Childhood obesity OT - Nutrition OT - Physical activity OT - Sleep OT - Socio-economic status EDAT- 2026/06/05 06:36 MHDA- 2026/06/05 06:36 CRDT- 2026/06/05 03:13 PHST- 2026/06/05 06:36 [pubmed] PHST- 2026/06/05 06:36 [medline] PHST- 2026/06/05 03:13 [entrez] AID - S0007114526107715 [pii] AID - 10.1017/S0007114526107715 [doi] PST - aheadofprint SO - Br J Nutr. 2026 Jun 5:1-14. doi: 10.1017/S0007114526107715. PMID- 42243691 OWN - NLM STAT- MEDLINE DCOM- 20260809 LR - 20260813 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jun 4 TI - A Bayesian multilevel joint model for predicting neonatal head circumference and body mass index: a case study in Dalahu County, Iran. LID - 10.1186/s12884-026-09377-7 [doi] LID - 862 AB - BACKGROUND: Newborn anthropometry is an essential research tool for assessing newborn growth and studying the factors that influence inadequate or excessive fetal growth. Newborn Body Mass Index (BMI) and Head Circumference (HC) are among the anthropometric measurements that are important to monitor from early infancy. This study aimed to identify the maternal, paternal, and pregnancy-related factors associated with newborn BMI and HC in Dalahoo County, Iran. METHODS: This retrospective cohort study included all pregnant women who attended primary health centers in Dalahoo County, located in the central regions of the western half of Kermanshah Province, Iran, from March 21, 2022, to May 19, 2024. The response variables included newborn HC as a continuous variable and newborn BMI as an ordinal variable. BMI was categorized based on sex-and age-specific reference values provided by World Health Organization (WHO). Newborn BMI and HC were examined concurrently to assess factors influencing newborn development using a Bayesian multilevel joint modeling approach. RESULTS: For each additional week of gestation, the odds of being in a higher BMI category increased (OR 1.45; 95% HPD 1.31-1.65). Newborns with smoking fathers had lower odds of being in a higher BMI category than those with non-smoking fathers (OR 0.41; 95% HPD 0.36-0.47). Newborns of mothers with Gestational Diabetes Mellitus (GDM) had higher odds of being in a higher BMI category than those of non-diabetic mothers (OR 2.56; 95% HPD 2.18-2.92). Male newborns had higher odds of being in a higher BMI category than females (OR 1.40; 95% HPD 1.22-1.60). For head circumference, each additional week of gestation increased the mean by 0.44 cm (posterior mean, 0.44; 95% HPD, 0.42-0.45). Male newborns had a larger mean head circumference (posterior mean difference, 0.24 cm; 95% HPD, 0.05-0.38). All associations were interpreted while holding other variables constant. CONCLUSIONS: In this cohort study, gestational age (per week), Gestational Diabetes Mellitus (GDM), and male sex were associated with higher odds of being in a higher newborn BMI category, whereas paternal smoking was associated with lower odds. Gestational age and male sex were associated with a larger mean Head Circumference (HC). Joint modeling of BMI and HC within a Bayesian multilevel framework allowed simultaneous estimation of both outcomes while accounting for outcome correlation, supporting the assessment of BMI and HC together in newborn growth. However, given the limitations of external validity, these findings should be interpreted with caution and are not intended as direct clinical recommendations. CI - (c) 2026. The Author(s). FAU - Fallah, Sahar AU - Fallah S AD - Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. FAU - Andayeshgar, Bahare AU - Andayeshgar B AD - Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. FAU - Amini, Payam AU - Amini P AD - School of Medicine, Keele University, Keele, Staffordshire, UK. FAU - Mahaki, Behzad AU - Mahaki B AD - Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. AD - Health Data Science Research Center, Health Research Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. FAU - Shahsavari, Soodeh AU - Shahsavari S AD - Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. soodeh_shahsavari@yahoo.com. AD - Health Data Science Research Center, Health Research Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. soodeh_shahsavari@yahoo.com. FAU - Hashemian, Amir Hossein AU - Hashemian AH AD - Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. dr.ahashemian@gmail.com. FAU - Fournier, Andrew AU - Fournier A AD - College of Doctoral Studies, Grand Canyon University, Phoenix, AZ, USA. LA - eng PT - Journal Article DEP - 20260604 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Bayes Theorem MH - Iran MH - *Body Mass Index MH - Infant, Newborn MH - Retrospective Studies MH - Pregnancy MH - *Head/anatomy & histology MH - Male MH - *Cephalometry/methods MH - Adult MH - Gestational Age MH - Smoking/epidemiology PMC - PMC13455485 OTO - NOTNLM OT - Bayesian Joint Model OT - Body Mass Index OT - Head Circumference OT - Multilevel OT - Random Intercept COIS- Declarations. Ethics approval and consent to participate: Approved by the ethics committee of Kermanshah University of Medical Sciences (ID: IR.KUMS.REC.1402.034). Participant confidentiality was maintained; informed consent was obtained. Procedures adhered to the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/05 00:35 MHDA- 2026/08/10 00:40 PMCR- 2026/06/04 CRDT- 2026/06/04 23:55 PHST- 2025/09/16 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/08/10 00:40 [medline] PHST- 2026/06/05 00:35 [pubmed] PHST- 2026/06/04 23:55 [entrez] PHST- 2026/06/04 00:00 [pmc-release] AID - 10.1186/s12884-026-09377-7 [pii] AID - 9377 [pii] AID - 10.1186/s12884-026-09377-7 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jun 4;26(1):862. doi: 10.1186/s12884-026-09377-7. PMID- 42242500 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 74 DP - 2026 Aug TI - Development and internal validation of a bioimpedance-based predictive model for assessing fat-free mass in infants, children and adolescents: Accuracy meets practicality. PG - 103367 LID - S2405-4577(26)00463-8 [pii] LID - 10.1016/j.clnesp.2026.103367 [doi] AB - BACKGROUND AND AIMS: Accurate evaluation of body composition in infants, children and adolescents is essential for monitoring growth and nutritional status. Reference methods such as air displacement plethysmography (ADP) and dual-energy X-ray absorptiometry (DXA) offer high accuracy but are costly and limited to specialized settings. Bioelectrical impedance analysis (BIA) provides a portable, non-invasive alternative; however, predictive equations for estimating fat-free mass (FFM) in pediatric populations require further validation. Considering this, our study aimed to develop and validate a BIA-based predictive model for estimating FFM in healthy subjects from birth to 18 years, using ADP as reference method. METHODS: An exploratory cross-sectional study was conducted on 142 participants (86 aged 0-1 year; 56 aged 2-18 years). Anthropometric and bioelectrical impedance parameters were collected following standardized protocols. Participants were randomly assigned to training (70%) and validation (30%) cohorts. Multiple linear regression models incorporating weight, length/height, sex, and impedance variables were tested. Model performance was evaluated using adjusted R(2) and root mean square error (RMSE); agreement with ADP-derived FFM was assessed through Bland-Altman analysis. RESULTS: In both age groups, models including impedance-index outperformed anthropometry-only models. The best model (weight + sex + impedance index [L(2)/R(50)]) achieved excellent predictive accuracy (0-1 year: adjusted R(2) = 0.953, RMSE = 0.183 kg; 2-18 years: adjusted R(2) = 0.987, RMSE = 1.409 kg). Bland-Altman analysis showed minimal bias and narrow limits of agreement. CONCLUSIONS: the proposed developed BIA-based equation provides a practical, reliable, and highly accurate tool for estimating FFM across pediatric ages, supporting its potential application in clinical practice. However, the present findings are based on an internal validation using a split-sample strategy, and external validation in independent cohorts is warranted to confirm the generalizability of the proposed equation. CI - Copyright (c) 2026 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. FAU - Perrone, Michela AU - Perrone M AD - NICU, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy. FAU - Roggero, Paola AU - Roggero P AD - NICU, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy. Electronic address: paola.roggero@unimi.it. FAU - Nicora, Arianna AU - Nicora A AD - NICU, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy. FAU - Torcasio, Benedetta AU - Torcasio B AD - NICU, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy. FAU - Pesenti, Nicola AU - Pesenti N AD - Division of Biostatistics, Epidemiology, and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy. FAU - Tabasso, Chiara AU - Tabasso C AD - NICU, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy. FAU - Fumagalli, Monica AU - Fumagalli M AD - NICU, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy; Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, Universita degli Studi di Milano, 20122 Milan, Italy. LA - eng PT - Journal Article PT - Validation Study DEP - 20260603 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM MH - Humans MH - Adolescent MH - *Electric Impedance MH - Child MH - Child, Preschool MH - Female MH - Male MH - *Body Composition MH - Infant MH - Cross-Sectional Studies MH - Reproducibility of Results MH - Absorptiometry, Photon MH - Anthropometry MH - Infant, Newborn MH - Nutritional Status MH - Linear Models OTO - NOTNLM OT - Bioimpedance OT - Body composition OT - Growth OT - Nutritional status COIS- Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/05 00:34 MHDA- 2026/06/27 00:57 CRDT- 2026/06/04 19:35 PHST- 2025/11/24 00:00 [received] PHST- 2026/04/24 00:00 [revised] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/06/27 00:57 [medline] PHST- 2026/06/05 00:34 [pubmed] PHST- 2026/06/04 19:35 [entrez] AID - S2405-4577(26)00463-8 [pii] AID - 10.1016/j.clnesp.2026.103367 [doi] PST - ppublish SO - Clin Nutr ESPEN. 2026 Aug;74:103367. doi: 10.1016/j.clnesp.2026.103367. Epub 2026 Jun 3. PMID- 42238684 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260604 LR - 20260813 IS - 2055-2076 (Print) IS - 2055-2076 (Electronic) IS - 2055-2076 (Linking) VI - 12 DP - 2026 Jan-Dec TI - The association between digital health literacy and healthy lifestyle behaviors among youth: Systematic review of cross-sectional studies. PG - 20552076261456577 LID - 10.1177/20552076261456577 [doi] LID - 20552076261456577 AB - OBJECTIVE: To systematically identify and critically evaluate research evidence on the association between digital health literacy (DHL) and healthy lifestyle behaviors (HLB) among youth. METHODS: A systematic search was conducted of five English-language databases-Web of Science, Scopus, ProQuest, EBSCO, and PubMed-covering publications from January 2006 to October 2025. This search was supplemented by reference list screening, resulting in the inclusion of 33 studies in the final review. RESULTS: Overall, youth exhibit a relatively high level of DHL, and the eHealth Literacy Scale (eHEALS) is the most frequently employed instrument for its assessment. HLB associated with DHL primarily encompassed domains such as physical activity, sleep, diet and nutrition, as well as mental health and stress management. Higher levels of DHL among youth were associated with more favorable HLB, but the magnitude and consistency of these associations varied across behavioral domains. CONCLUSION: This study aims to examine variations in the role of DHL across different HLB domains, guided by the COM-B behavior change model, which emphasizes the interaction of capability, opportunity, and motivation. Further research is warranted to clarify the mechanisms linking DHL with specific HLB, particularly through high-quality longitudinal and intervention studies. In addition, DHL measurement instruments should be refined to ensure their validity and applicability within the rapidly evolving digital health environment. CI - (c) The Author(s) 2026. FAU - Xu, Ruilin AU - Xu R AUID- ORCID: 0009-0009-0141-2545 AD - College of Physical Education and Health, East China Normal University, Shanghai, China. RINGGOLD: 12655 FAU - Jiang, Jiajun AU - Jiang J AUID- ORCID: 0009-0006-5834-0712 AD - College of Physical Education and Health, East China Normal University, Shanghai, China. RINGGOLD: 12655 FAU - Yin, Zhihua AU - Yin Z AD - College of Physical Education and Health, East China Normal University, Shanghai, China. RINGGOLD: 12655 FAU - Zhong, Qiying AU - Zhong Q AD - College of Physical Education and Health, East China Normal University, Shanghai, China. RINGGOLD: 12655 FAU - Liu, Duoer AU - Liu D AD - College of Physical Education and Health, East China Normal University, Shanghai, China. RINGGOLD: 12655 FAU - Sun, Mingzhu AU - Sun M AD - College of Physical Education and Health, East China Normal University, Shanghai, China. RINGGOLD: 12655 FAU - Xiong, Mingliang AU - Xiong M AD - College of Physical Education and Health, East China Normal University, Shanghai, China. RINGGOLD: 12655 AD - College of Physical Education, Hunan First Normal University, Changsha, China. LA - eng PT - Journal Article PT - Review DEP - 20260531 PL - United States TA - Digit Health JT - Digital health JID - 101690863 PMC - PMC13226989 OTO - NOTNLM OT - digital health literacy OT - healthy lifestyle behaviors OT - systematic review OT - youth COIS- The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/06/04 06:33 MHDA- 2026/06/04 06:34 PMCR- 2026/05/31 CRDT- 2026/06/04 05:30 PHST- 2026/01/30 00:00 [received] PHST- 2026/04/22 00:00 [revised] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/06/04 06:34 [medline] PHST- 2026/06/04 06:33 [pubmed] PHST- 2026/06/04 05:30 [entrez] PHST- 2026/05/31 00:00 [pmc-release] AID - 10.1177_20552076261456577 [pii] AID - 10.1177/20552076261456577 [doi] PST - epublish SO - Digit Health. 2026 May 31;12:20552076261456577. doi: 10.1177/20552076261456577. eCollection 2026 Jan-Dec. PMID- 42238253 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260604 LR - 20260813 IS - 2472-1972 (Electronic) IS - 2472-1972 (Linking) VI - 10 IP - 6 DP - 2026 Jun TI - Real-world growth outcomes of vosoritide in children with achondroplasia: a single-center cohort study. PG - bvag072 LID - 10.1210/jendso/bvag072 [doi] LID - bvag072 AB - CONTEXT: Vosoritide, a C-type natriuretic peptide analogue, is the first approved therapy targeting the pathophysiology of achondroplasia. While clinical trials demonstrate efficacy, individuals with prior orthopedic surgeries are typically excluded, and real-world data remain limited. OBJECTIVE: To evaluate real-world growth outcomes of vosoritide therapy in children with achondroplasia, including those with prior surgical interventions. METHODS: This retrospective analysis included 25 children with achondroplasia (17 boys, age range 2.9-14.3 years) treated with vosoritide for a mean duration of 12.7 months at a multidisciplinary center. Z-scores were calculated using an AI-assisted growth assessment tool previously validated for children with achondroplasia. Delta z-scores for height, sitting height, arm span, and body mass index (BMI) were calculated from baseline to follow-up. Multiple linear regression analyses assessed predictors of response. RESULTS: Mean height z-scores improved from -0.62 +/- 1.09 to -0.24 +/- 1.20 (P < .001). Mean arm span z-score increased from -1.28 +/- 0.93 to -0.96 +/- 0.91 (P = .007). Sitting height z-scores showed a non-significant trend toward improvement; BMI z-scores remained stable. Mean Delta height and Delta arm span z-score gains were +0.38 +/- 0.45 and +0.32 +/- 0.48, respectively. A subgroup analysis of 8 patients with vs 17 without prior limb-lengthening surgery showed no significant differences. Regression analyses adjusted for sex, age, BMI z-scores, and surgical history were likely underpowered to detect meaningful predictors of response. There were no serious treatment-related adverse events. CONCLUSION: Vosoritide therapy enhanced linear and appendicular growth in a real-world cohort of children with achondroplasia, including post-surgical patients. These findings align with clinical trial data and support the therapy's applicability across diverse clinical profiles. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Endocrine Society. FAU - Regev, Ravit AU - Regev R AUID- ORCID: 0000-0002-0846-733X AD - Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel, affiliated to The Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Waksman, Yarden AU - Waksman Y AD - Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel, affiliated to The Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Cohen-Sela, Eyal AU - Cohen-Sela E AUID- ORCID: 0009-0008-0083-9443 AD - Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel, affiliated to The Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Brener, Avivit AU - Brener A AUID- ORCID: 0000-0002-2742-8264 AD - Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel, affiliated to The Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Dechovich, Nechama AU - Dechovich N AD - Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel, affiliated to The Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Gal, Maya AU - Gal M AD - Department of Occupational Therapy, The Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel. FAU - Borger, Ophir AU - Borger O AUID- ORCID: 0000-0001-6019-4159 AD - Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel, affiliated to The Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. AD - The Nutrition & Dietetics Unit, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel. FAU - Zeitlin, Leonid AU - Zeitlin L AD - Pediatric Orthopedic Department, Dana-Dwek Children's Hospital, Tel Aviv 6423906, Israel. FAU - Lebenthal, Yael AU - Lebenthal Y AUID- ORCID: 0000-0001-5963-0574 AD - Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel, affiliated to The Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. LA - eng PT - Journal Article DEP - 20260328 PL - United States TA - J Endocr Soc JT - Journal of the Endocrine Society JID - 101697997 PMC - PMC13227001 OTO - NOTNLM OT - C-type natriuretic peptide (CNP) analog OT - achondroplasia OT - body proportions OT - growth-promoting therapy OT - skeletal dysplasia OT - vosoritide EDAT- 2026/06/04 06:32 MHDA- 2026/06/04 06:33 PMCR- 2026/03/28 CRDT- 2026/06/04 05:26 PHST- 2025/12/03 00:00 [received] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/06/04 06:33 [medline] PHST- 2026/06/04 06:32 [pubmed] PHST- 2026/06/04 05:26 [entrez] PHST- 2026/03/28 00:00 [pmc-release] AID - bvag072 [pii] AID - 10.1210/jendso/bvag072 [doi] PST - epublish SO - J Endocr Soc. 2026 Mar 28;10(6):bvag072. doi: 10.1210/jendso/bvag072. eCollection 2026 Jun. PMID- 42237980 OWN - NLM STAT- MEDLINE DCOM- 20260609 LR - 20260813 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 15 DP - 2026 TI - Nutritional knowledge of team sport athletes. PG - e39 LID - 10.1017/jns.2026.10107 [doi] LID - e39 AB - Adequate nutritional knowledge (NK) is an essential aspect of team sport athletes (TSA) meeting their nutritional requirements, yet limited research has examined the NK of TSA using validated tools. This study aimed to assess the NK of male and female TSA using the validated Nutrition for Sport Knowledge Questionnaire (NSKQ) which was administered via the online platform REDCap. A total of 920 athletes (male n = 576 [62.6%], female n = 344 [37.4%]) from a range of sports including, Gaelic football n = 576 (62.6%), hurling & camogie n = 133 (14.5%), rugby n = 107 (11.6%) and soccer n = 104 (11.3%) completed the study. Participants were recruited from elite (county, country, province, professional) n = 343 (37.3%) and non-elite (club, university) n = 577 (62.7%) teams. The mean total score was 50.4 +/- 12.78%, considered 'average' using accepted cut-offs. Across sports, rugby players' total score was significantly higher when compared to Gaelic field sport athletes (p =.002). Scores in all NSKQ sub-sections fell within the 'average' or 'poor' category. NK was classified as 'poor' in the micronutrients (42.77 +/- 19.89%), sports nutrition (46.93 +/- 17.55%) and supplementation (35.42 +/- 18.86%) sub-sections, with 'poor' scoring in these sub-sections observed across all sports. In this study, NK was sub-optimal in 89.8% (n = 826) of participants and although 74.9% of participants expressed a desire for access to nutritional resources, the majority (64.3%) reported having no such access, as indicated by participant responses from the demographic section of NSKQ. These findings suggest TSA may benefit from tailored nutrition education interventions to enhance NK, potentially improving dietary intake and subsequently health and performance outcomes. CI - (c) The Author(s) 2026. FAU - McDonald, Chris V AU - McDonald CV AD - Nutrition Innovation Centre for Food & Health (NICHE), Ulster University, Coleraine, UK. ROR: https://ror.org/03hab3x36 FAU - McSorley, Emeir M AU - McSorley EM AUID- ORCID: 0000-0003-1861-3991 AD - Nutrition Innovation Centre for Food & Health (NICHE), Ulster University, Coleraine, UK. ROR: https://ror.org/03hab3x36 FAU - McNeilly, Andrea M AU - McNeilly AM AD - School of Sport and Exercise Sciences, Ulster University, Belfast, UK. FAU - Magee, Pamela J AU - Magee PJ AUID- ORCID: 0000-0002-0479-3314 AD - Nutrition Innovation Centre for Food & Health (NICHE), Ulster University, Coleraine, UK. ROR: https://ror.org/03hab3x36 LA - eng PT - Journal Article DEP - 20260601 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 SB - IM MH - Humans MH - Male MH - Female MH - *Athletes MH - *Health Knowledge, Attitudes, Practice MH - Surveys and Questionnaires MH - Young Adult MH - Adult MH - Nutritional Requirements MH - Gaelic Football MH - Soccer MH - *Sports Nutritional Physiological Phenomena MH - *Team Sports MH - Adolescent PMC - PMC13227125 OTO - NOTNLM OT - GAA OT - Nutritional knowledge OT - Rugby OT - Soccer OT - Team sport athlete EDAT- 2026/06/04 06:33 MHDA- 2026/06/10 06:52 PMCR- 2026/06/01 CRDT- 2026/06/04 05:24 PHST- 2025/12/08 00:00 [received] PHST- 2026/03/26 00:00 [revised] PHST- 2026/04/27 00:00 [accepted] PHST- 2026/06/10 06:52 [medline] PHST- 2026/06/04 06:33 [pubmed] PHST- 2026/06/04 05:24 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - S2048679026101074 [pii] AID - 10.1017/jns.2026.10107 [doi] PST - epublish SO - J Nutr Sci. 2026 Jun 1;15:e39. doi: 10.1017/jns.2026.10107. eCollection 2026. PMID- 42237838 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260813 IS - 0971-5916 (Print) IS - 0971-5916 (Linking) VI - 163 IP - 5 DP - 2026 May TI - Untangling weight from height: A generalised body mass index (gBMI) approach to evaluating child and adolescent nutritional status in India. PG - 655-663 LID - 10.25259/IJMR_2555_2025 [pii] AB - Background and objectives Weight-for-height (WHZ) and body mass index (BMI)-for-age (BAZ) are commonly used to assess child overnutrition but have limitations: they conflate skeletal growth with body weight, correlate with height, and inadequately distinguish fat from lean mass, particularly during puberty. This study proposes an India-specific generalised body mass index (gBMI), an age- and sex-specific power-type index adapted from Benn's concept, to better capture adiposity. Methods Exponent parameters for gBMI were estimated using healthy-child data, selected by WHO selection criteria, from the National Family Health Survey (NFHS-3,4,5) and the Comprehensive National Nutrition Survey (CNNS), comprising 12,466 children under 5 years and 6,487 aged 5-19 years. Polynomial regression to model age- and sex-specific variation in the weight-height relationship was used to estimate the exponents of height, and growth curves were generated using generalised additive models for location, scale, and shape (GAMLSS) with location scale and shape (LMS) methods. Validation employed independent data from 457 urban schoolchildren aged 5-16 years in Bengaluru, including fat and lean mass measured by dual-energy X-ray absorptiometry (DXA). Results The exponent varied with age (1.3 in infancy, approximately 2.9 in pubertal boys, 2.7 in girls, stabilising at approximately 2 in late adolescence). Unlike BMI, gBMI residuals showed near-zero correlation with height. gBMI-for-age Z-scores (gBAZ) showed lower wasting in children under 5 years (10.7% vs. 19.2% using WHZ) and higher adolescent overnutrition (8.7% vs. <1% using BAZ). Validation showed stronger association of gBAZ with body fat (r=0.70) than BAZ (r=0.65). Interpretation and conclusions The gBMI provides an adaptable, height-independent, and adiposity-sensitive index for assessing malnutrition and obesity in children and adolescents. Its use could refine nutritional surveillance and interventions, with potential wider applicability with longitudinal evaluations. FAU - Majumder, Rajesh AU - Majumder R AD - Department of Biostatistics, Manipal Academy of Higher Education, Manipal, Karnataka, India. AD - Division of Biostatistics and Epidemiology, St John's Research Institute, Bengaluru, Karnataka, India. FAU - Kurpad, Anura Viswanath AU - Kurpad AV AD - Department of Physiology, St John's Medical College, Bengaluru, Karnataka, India. FAU - Sachdev, Harshpal Singh AU - Sachdev HS AD - Department of Pediatrics, Sitaram Bhartia Institute of Science and Research, New Delhi, India. FAU - Kuriyan, Rebecca AU - Kuriyan R AD - Division of Nutrition, St John's Research Institute, Bengaluru, Karnataka, India. AD - Department of Physiology, St John's Medical College, Bengaluru, Karnataka, India. FAU - Thomas, Tinku AU - Thomas T AD - Department of Biostatistics, St John's Medical College, Bengaluru, Karnataka, India. FAU - Ghosh, Santu AU - Ghosh S AD - Department of Biostatistics, St John's Medical College, Bengaluru, Karnataka, India. LA - eng PT - Journal Article PL - United States TA - Indian J Med Res JT - The Indian journal of medical research JID - 0374701 SB - IM MH - Humans MH - Body Mass Index MH - Child MH - India/epidemiology MH - Male MH - Adolescent MH - *Nutritional Status/physiology MH - Child, Preschool MH - Female MH - *Body Weight/physiology MH - *Body Height/physiology MH - Adiposity/physiology MH - Nutrition Surveys MH - Young Adult MH - *Obesity/epidemiology/physiopathology MH - Absorptiometry, Photon PMC - PMC13235558 OTO - NOTNLM OT - Anthropometry OT - BMI OT - Obesity OT - Z-score OT - gBMI COIS- None. EDAT- 2026/06/04 06:34 MHDA- 2026/06/11 06:36 PMCR- 2026/05/01 CRDT- 2026/06/04 04:19 PHST- 2025/09/17 00:00 [received] PHST- 2025/12/09 00:00 [accepted] PHST- 2026/06/11 06:36 [medline] PHST- 2026/06/04 06:34 [pubmed] PHST- 2026/06/04 04:19 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - 10.25259/IJMR_2555_2025 [pii] AID - 10.25259/IJMR_2555_2025 [doi] PST - ppublish SO - Indian J Med Res. 2026 May;163(5):655-663. doi: 10.25259/IJMR_2555_2025. PMID- 42236840 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260815 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jun 3 TI - The normal distance from soft tissue nasion to the arbitrary axis-orbital plane is similar in pediatric, adolescent, and young adult samples. LID - 10.1038/s41598-026-56184-3 [doi] LID - 25260 AB - Anatomical facebows establish the arbitrary axis-orbital plane by assessing both the hinge axis points and landmark orbitale. The estimated point orbitale results from the facebow's nasion relator height of 25.4 mm. This height was investigated in adults but it is unclear if their anthropometric dimensions adequately translate to children and adolescents. The present cross-sectional study aimed to evaluate the validity of this height retrospectively for the ages 6 to19.9 years. We used lateral cephalometric radiographs of 420 individuals (210 males, 210 females,) and divided the sample into 7 age groups. A single investigator measured the perpendicular distance of soft tissue nasion to a line connecting the averaged arbitrary hinge axis point and the averaged point orbitale. Data were analyzed using an ordinary least squares linear regression model (p < 0.05). The perpendicular distances ranged from 11 to 33.5 mm (mean 22.8, standard deviation 3.5). There were no significant differences of the distance between age groups, or sex within age groups, or sex between age groups. The use of a fixed 25.4 mm nasion relator height in children and adolescents was not associated with more instrumental error in assessing point orbitale than in the adult age group. The present study's data did not preclude application of this nasion relator height from age 6 years onward. CI - (c) 2026. The Author(s). FAU - Celar, Ales AU - Celar A AD - Medical University of Vienna, University Clinic of Dentistry, Sensengasse 2a, 1090, Wien, Austria. ales.celar@meduniwien.ac.at. FAU - Lettner, Stefan AU - Lettner S AD - Medical University of Vienna, University Clinic of Dentistry, Sensengasse 2a, 1090, Wien, Austria. FAU - Jonke, Erwin AU - Jonke E AD - Medical University of Vienna, University Clinic of Dentistry, Sensengasse 2a, 1090, Wien, Austria. LA - eng PT - Journal Article DEP - 20260603 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Child MH - Adolescent MH - Female MH - *Orbit/anatomy & histology/diagnostic imaging MH - Male MH - *Cephalometry/methods MH - Young Adult MH - Cross-Sectional Studies MH - Adult MH - Retrospective Studies PMC - PMC13470210 OTO - NOTNLM OT - Anatomical facebow OT - Arbitrary facebow OT - Axis-orbital plane OT - Nasion relator height OT - Orbitale COIS- Declarations. Competing interests: Regarding the Competing Interests Statement, all authors declare that there are none and that no financial and non-financial conflicts of interest exist with respect to the authorship and/or publication of this article. EDAT- 2026/06/04 00:37 MHDA- 2026/08/13 05:35 PMCR- 2026/06/03 CRDT- 2026/06/03 23:34 PHST- 2026/03/06 00:00 [received] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/08/13 05:35 [medline] PHST- 2026/06/04 00:37 [pubmed] PHST- 2026/06/03 23:34 [entrez] PHST- 2026/06/03 00:00 [pmc-release] AID - 10.1038/s41598-026-56184-3 [pii] AID - 56184 [pii] AID - 10.1038/s41598-026-56184-3 [doi] PST - epublish SO - Sci Rep. 2026 Jun 3;16(1):25260. doi: 10.1038/s41598-026-56184-3. PMID- 42233406 OWN - NLM STAT- MEDLINE DCOM- 20260605 LR - 20260609 IS - 1464-5033 (Electronic) IS - 0301-4460 (Linking) VI - 53 IP - 1 DP - 2026 Dec TI - Body composition phenotyping of obesity in children aged 6-18 years: multi-strategy clustering and interpretable machine learning. PG - 2661592 LID - 10.1080/03014460.2026.2661592 [doi] AB - BACKGROUND: Body composition heterogeneity in childhood obesity is not fully captured by BMI, motivating operational phenotyping using non-invasive measures. AIM: To identify body composition-based phenotypes of obesity in children aged 6-18 years using complementary clustering approaches and characterise their discriminative structure through interpretable machine learning. SUBJECTS AND METHODS: We enrolled 78 obese children (6-18 years) from a single-centre outpatient clinic in a cross-sectional design. Thirteen BIA-derived indices were Z-standardised and analysed using parallel unsupervised strategies (PCA-K-means, HCPC, UMAP-DBSCAN). Cluster quality, stability, and agreement were evaluated by mean silhouette, Jaccard bootstrap (100 resamples), and adjusted Rand index (ARI). Separability was assessed with a random forest classifier using five-fold cross-validation (out-of-fold accuracy; macro/micro AUC), with SHAP for interpretability. RESULTS: Four phenotypes were consistently supported: low-fat/high-muscle, balanced, high-fat/low-muscle, and mixed high-fat/high-muscle. Cross-validated performance was 85.9% accuracy, macro AUC 0.953, and micro AUC 0.965. Structural metrics were silhouette 0.41 and ARI 0.94, with cluster-wise Jaccard 0.789/0.812/0.835/0.858 (range 0.78-0.86). SHAP prioritised fat mass and BMI; BIA-derived basal metabolic indices contributed as device-estimated outputs, while lean mass and skeletal muscle mass showed opposing contributions. CONCLUSIONS: This exploratory, single-centre framework is hypothesis-generating and requires external validation with outcome-linked markers and imaging before any clinical applicability is considered. FAU - Wang, Yuhang AU - Wang Y AUID- ORCID: 0009-0000-0454-3449 AD - Yiwu Maternity and Children Hospital, Yiwu, Zhejiang, China. AD - Department of Pediatrics, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China. FAU - Shi, Shuang AU - Shi S AD - Department of Pediatrics, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China. AD - Zhumadian Central Hospital, Zhumadian, Henan, China. FAU - Cai, Jin AU - Cai J AD - Department of Pediatrics, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China. LA - eng PT - Journal Article DEP - 20260603 PL - England TA - Ann Hum Biol JT - Annals of human biology JID - 0404024 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Body Composition/physiology MH - Cluster Analysis MH - *Clustering Algorithms MH - Cross-Sectional Studies MH - *Machine Learning MH - *Pediatric Obesity/diagnosis/physiopathology MH - *Phenotype OTO - NOTNLM OT - Childhood obesity OT - SHAP OT - bioelectrical impedance analysis OT - body composition OT - random forest OT - unsupervised clustering EDAT- 2026/06/03 12:38 MHDA- 2026/06/06 00:35 CRDT- 2026/06/03 07:13 PHST- 2026/06/06 00:35 [medline] PHST- 2026/06/03 12:38 [pubmed] PHST- 2026/06/03 07:13 [entrez] AID - 10.1080/03014460.2026.2661592 [doi] PST - ppublish SO - Ann Hum Biol. 2026 Dec;53(1):2661592. doi: 10.1080/03014460.2026.2661592. Epub 2026 Jun 3. PMID- 42233315 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260813 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2026 Jun 3 TI - Adapting and validating the FOODLIT-Tool in Turkish: a psychometric study on food literacy for sustainability. PG - e128 LID - 10.1017/S1368980026102821 [doi] LID - e128 AB - OBJECTIVE: This study aimed to adapt and validate the FOODLIT-Tool in Turkish to assess sustainable food literacy among Turkish adults. The adaptation addresses a lack of psychometrically validated instruments for measuring food literacy and sustainability-oriented eating behaviours in Turkey. DESIGN: A psychometric evaluation was conducted, including forward-translation, back-translation and cultural adaptation steps, followed by expert review for content validation. Construct validity was assessed using confirmatory factor analysis (CFA), and internal consistency was evaluated to ensure reliability. SETTING: Data collection was conducted online via Google Forms between July and August 2024. PARTICIPANTS: A total of 482 participants aged 18 to 65 years residing in Turkey voluntarily completed the Turkish version of the FOODLIT-Tool, along with a general information form and the Sustainable and Healthy Eating Behavior Scale. RESULTS: CFA results demonstrated an acceptable model fit (chi(2)/df = 3.67, CFI = 0.91, RMSEA = 0.07). Cronbach's alpha values ranged from 0.60 to 0.91 across the sub-dimensions, indicating adequate to excellent internal consistency. Significant positive correlations were found between FOODLIT subscales and sustainable eating behaviours. Women scored significantly higher in culinary competence, production quality and environmental awareness. CONCLUSIONS: The adapted Turkish version of the FOODLIT-Tool demonstrates satisfactory validity and reliability for evaluating food literacy and sustainable dietary practices among Turkish adults. The scale serves as a useful assessment tool for future research and intervention studies focusing on sustainable nutrition. Further validation using representative samples and longitudinal designs is warranted before its application in public health or policy-making contexts. FAU - Atar, Aslihan AU - Atar A AUID- ORCID: 0000-0003-2941-4269 AD - Nutrition and Dietetics, Istanbul Beykent Universitesi, Turkiye. AD - Istanbul Medipol University - Kavacik Campus, Turkiye. FAU - Sahin Anilgan, Irem Nur AU - Sahin Anilgan IN AUID- ORCID: 0000-0002-5446-9467 AD - https://ror.org/054xkpr46Gazi University, Turkiye. AD - https://ror.org/03dcvf827Istanbul Beykent University - Beylikduzu Campus, Turkiye. FAU - Pulat Demir, Halime AU - Pulat Demir H AD - Nutrition and Dietetics, Istanbul Beykent Universitesi, Turkiye. LA - eng PT - Journal Article PT - Validation Study DEP - 20260603 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Turkey MH - *Psychometrics MH - Female MH - Reproducibility of Results MH - Adult MH - Middle Aged MH - *Health Literacy MH - Adolescent MH - Male MH - *Diet, Healthy/psychology MH - Young Adult MH - Surveys and Questionnaires/standards MH - Aged MH - *Feeding Behavior/psychology MH - Factor Analysis, Statistical PMC - PMC13434619 OTO - NOTNLM OT - Food literacy OT - Turkish adults OT - nutrition OT - psychometric validation OT - sustainability COIS- None. EDAT- 2026/06/03 12:40 MHDA- 2026/06/23 18:33 PMCR- 2026/06/03 CRDT- 2026/06/03 06:13 PHST- 2026/06/23 18:33 [medline] PHST- 2026/06/03 12:40 [pubmed] PHST- 2026/06/03 06:13 [entrez] PHST- 2026/06/03 00:00 [pmc-release] AID - S1368980026102821 [pii] AID - 10.1017/S1368980026102821 [doi] PST - epublish SO - Public Health Nutr. 2026 Jun 3;29(1):e128. doi: 10.1017/S1368980026102821. PMID- 42232274 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260603 LR - 20260813 IS - 2221-2965 (Electronic) IS - 2221-2965 (Linking) VI - 11 DP - 2025 TI - Robotic versus non-robotic endoscopic invasive mitral valve repair: a narrative review of current evidence and evolving practice. PG - 23 LID - 10.21037/jovs-25-26 [doi] LID - 23 AB - BACKGROUND AND OBJECTIVE: Mitral valve repair is the gold standard for degenerative disease, with access evolving from sternotomy to minimally invasive thoracoscopic and robotic techniques. Both are safe, widely used, and reproducible. This narrative review compares robotic and non-robotic approaches regarding outcomes and efficiency. METHODS: A literature search was conducted using PubMed, Embase, Cochrane Library, and Scopus, including studies published January 1990-January 2025. The Boolean search strategy included: "mitral valve" AND "robotic" AND "endoscopic" OR "thoracoscopic" OR "minimally invasive". The search was limited to English-language articles. Eligible studies were peer-reviewed and directly compared robotic versus non-robotic endoscopic mitral valve repair in adults (>/=18 years) with mitral regurgitation. Abstracts, conference proceedings, reviews, meta-analyses, pediatric studies, case reports <10 patients, and non-comparative studies were excluded. KEY CONTENT AND FINDINGS: A total of 9 studies were included. Patient age ranged 46-69 years, mostly male. Body mass index (BMI) was similar across groups. Mitral valve repair was performed in all cases. Operative times were longer in the robotic group: cardiopulmonary bypass (CPB) ranged 85 [interquartile range (IQR), 73-105] to 275 [standard deviation (SD) +/-56] minute, and cross-clamp 57 (IQR, 48-67) to 152 (SD +/-38) minute. Intensive care units (ICU) stay varied, with Albano et al. reporting 41 (IQR, 20-45) vs. 45 (IQR, 43-73) h and Rufa et al. 20.5 (IQR, 20-40) vs. 22 (IQR, 20-27.5) h for robotic vs. endoscopic cohorts. Ventilation was shorter with robotics: 3 (IQR, 0-6) vs. 6 (IQR, 4-10) h. Neurologic events were uncommon in both groups (1-3.2% robotic vs. 1.3-4.8% endoscopic). Atrial fibrillation (AF) incidence ranged 17.6-50%, generally higher in endoscopic groups. In-hospital mortality was consistently <1%. Median hospital stay was shorter in robotic groups: 8-10 vs. 9-11 days in endoscopic ones. CONCLUSIONS: Minimally invasive mitral valve repair is safe and reproducible, with no survival difference between robotic and non-robotic approaches. Robotic cases showed longer bypass and cross-clamp times but shorter hospital stays. Transfusion needs were inconsistent, neurologic complications were rare and slightly fewer with robotics, and both methods showed excellent mid-term durability. Further studies are necessary to confirm these data. CI - (c) AME Publishing Company. FAU - Tropea, Ilaria AU - Tropea I AD - Division of Cardiac Surgery, San Bortolo Hospital, Vicenza, Italy. FAU - Grazioli, Valentina AU - Grazioli V AD - Division of Cardiac Surgery, San Bortolo Hospital, Vicenza, Italy. FAU - Cresce, Giovanni Domenico AU - Cresce GD AUID- ORCID: 0000-0001-8266-7340 AD - Division of Cardiac Surgery, San Bortolo Hospital, Vicenza, Italy. FAU - Salvador, Loris AU - Salvador L AD - Division of Cardiac Surgery, San Bortolo Hospital, Vicenza, Italy. FAU - Geirrson, Arnar AU - Geirrson A AD - Division of Cardiothoracic and Vascular Surgery, Columbia University Irving Medical Center, New York, NY, USA. FAU - Danesi, Tommaso Hinna AU - Danesi TH AD - Division of Cardiac Surgery, Department of Surgery, Brigham and Women's Hospital Heart and Vascular Center, Boston, MA, USA. LA - eng PT - Journal Article PT - Review DEP - 20250926 PL - China TA - J Vis Surg JT - Journal of visualized surgery JID - 101677561 PMC - PMC13224994 OTO - NOTNLM OT - Robotic mitral valve repair OT - endoscopic mitral valve repair OT - minimally invasive cardiac surgery OT - outcomes COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jovs.amegroups.com/article/view/10.21037/jovs-25-26/coif). The series "Endoscopic Cardiac Surgery" was commissioned by the editorial office without any funding or sponsorship. T.H.D. served as the unpaid Guest Editor of the series and serves as an unpaid editorial board member of Journal of Visualized Surgery from September 2024 to August 2026; and reports receiving consulting fees and payment/honoraria from Corcym. A.G. reports receiving consulting fees from Edwards Lifescience and Medtronic. The authors have no other conflicts of interest to declare. EDAT- 2026/06/03 06:35 MHDA- 2026/06/03 06:36 PMCR- 2025/09/26 CRDT- 2026/06/03 04:48 PHST- 2025/06/26 00:00 [received] PHST- 2025/09/17 00:00 [accepted] PHST- 2026/06/03 06:36 [medline] PHST- 2026/06/03 06:35 [pubmed] PHST- 2026/06/03 04:48 [entrez] PHST- 2025/09/26 00:00 [pmc-release] AID - jovs-11-23 [pii] AID - 10.21037/jovs-25-26 [doi] PST - epublish SO - J Vis Surg. 2025 Sep 26;11:23. doi: 10.21037/jovs-25-26. eCollection 2025. PMID- 42230735 OWN - NLM STAT- MEDLINE DCOM- 20260812 LR - 20260814 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jun 1 TI - A nomogram for risk stratification of protein-energy malnutrition in pediatric cancer patients: development and internal validation. LID - 10.1038/s41598-026-56183-4 [doi] LID - 25042 AB - To develop and internally validate a nomogram for predicting the risk of protein-energy malnutrition (PEM) in pediatric cancer patients and to evaluate its clinical utility. A total of 375 pediatric cancer patients admitted to a tertiary hospital in Xinjiang (January-May 2025) were enrolled. Nutritional status was assessed using the WHO BMI-for-age Z-score. Candidate variables (P < 0.01 in univariate analysis) were entered into the least absolute shrinkage and selection operator (LASSO) model, and multivariate logistic regression was applied to construct the prediction model. Model performance was assessed using the area under the receiver operating characteristic curve (AUC), calibration plots with the Hosmer-Lemeshow test, and decision curve analysis (DCA). Six readily obtainable variables were retained in the final model. Protective factors included being an only child (OR = 0.278), time since diagnosis of 0-6 months (OR = 0.264) or > 12 months (OR = 0.351), caregiver education of high school or above (OR = 0.406), and household per-capita income >/= 1,000 yuan (OR = 0.255). Rural residence (OR = 2.643) and >/= 6 chemotherapy cycles (OR = 2.259) were risk factors for PEM. The nomogram demonstrated robust discrimination in both the modeling (AUC = 0.823, 95% CI: 0.767-0.868) and validation (AUC = 0.779, 95% CI: 0.685-0.859) cohorts. Calibration curves showed close agreement between predicted and observed probabilities, and Hosmer-Lemeshow tests indicated good fit (all P > 0.05). DCA confirmed meaningful net clinical benefit across a wide range of threshold probabilities. The nomogram provides an interpretable and clinically practical tool for early identification of PEM risk in pediatric cancer patients, supporting targeted nutritional screening and timely intervention. CI - (c) 2026. The Author(s). FAU - Zhang, Hong AU - Zhang H AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China. FAU - Ho, Ka Yan AU - Ho KY AD - School of Nursing, The Hong Kong Polytechnic University, HKSAR, Hung Hom, China. FAU - Yorke, Janelle AU - Yorke J AD - School of Nursing, The Hong Kong Polytechnic University, HKSAR, Hung Hom, China. FAU - Mao, Ting AU - Mao T AD - School of Nursing, The Hong Kong Polytechnic University, HKSAR, Hung Hom, China. FAU - Abulaiti, Gulisumuhan AU - Abulaiti G AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China. FAU - Dong, Shuwan AU - Dong S AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China. dongshuwan2025@163.com. LA - eng GR - 2023D01C108/Natural Science Foundation of Xinjiang Uygur Autonomous Region/ PT - Journal Article DEP - 20260601 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Nomograms MH - Female MH - Child MH - Male MH - *Neoplasms/complications MH - Child, Preschool MH - *Protein-Energy Malnutrition/etiology/epidemiology/diagnosis MH - Risk Factors MH - Risk Assessment MH - Infant MH - Adolescent MH - ROC Curve MH - Nutritional Status PMC - PMC13463097 OTO - NOTNLM OT - Nomogram OT - Pediatric cancer OT - Prediction model OT - Protein-energy malnutrition COIS- Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: This study was approved by the Ethics Committee of the First Affiliated Hospital of Xinjiang Medical University (K202504-38), and written informed consent was obtained from all patients. EDAT- 2026/06/03 00:37 MHDA- 2026/08/12 06:05 PMCR- 2026/06/01 CRDT- 2026/06/02 23:37 PHST- 2026/01/26 00:00 [received] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/08/12 06:05 [medline] PHST- 2026/06/03 00:37 [pubmed] PHST- 2026/06/02 23:37 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - 10.1038/s41598-026-56183-4 [pii] AID - 56183 [pii] AID - 10.1038/s41598-026-56183-4 [doi] PST - epublish SO - Sci Rep. 2026 Jun 1;16(1):25042. doi: 10.1038/s41598-026-56183-4. PMID- 42230396 OWN - NLM STAT- MEDLINE DCOM- 20260605 LR - 20260922 IS - 1433-7339 (Electronic) IS - 0941-4355 (Print) IS - 0941-4355 (Linking) VI - 34 IP - 6 DP - 2026 Jun 2 TI - Nutritional status, dietary antioxidant capacity, and dietary diversity in patients with newly diagnosed hematological malignancies: a case-control study. LID - 10.1007/s00520-026-10817-5 [doi] LID - 604 AB - PURPOSE: Nutritional status and dietary antioxidant capacity are important determinants of clinical resilience in cancer; however, data in hematological malignancies remain limited. We aimed to compare nutritional status, dietary total antioxidant capacity (DTAC), and dietary diversity between patients with newly diagnosed hematological malignancies and healthy controls. METHODS: This case-control study included 34 patients with newly diagnosed hematological malignancies (12 lymphoma, 11 leukaemia, 11 multiple myeloma) and 34 age- and sex-matched healthy controls aged 18-65 years. DTAC was estimated using the ferric reducing antioxidant power (FRAP) method based on a validated food frequency questionnaire. Nutrient intakes and the dietary diversity score (DDS) were derived from 3-day dietary records. Nutritional status was assessed using the Global Leadership Initiative on Malnutrition (GLIM) criteria, along with fat-free mass index (FFMI), and mid-upper arm circumference (MUAC). RESULTS: Patients had significantly lower DTAC levels than controls (3.85 +/- 1.58 vs. 8.68 +/- 3.21 mmol/day, p < 0.05). According to GLIM criteria, 35.3% of patients had moderate malnutrition and 26.5% had severe malnutrition, A declining trend in DTAC was observed with worsening malnutrition (p = 0.034), although this did not reach the significance threshold after multiplicity adjustment. Low muscle mass was more prevalent in patients as assessed by both FFMI and MUAC. Energy, protein, zinc, vitamin E, and folate intakes were significantly lower in patients (all p < 0.05), whereas DDS did not differ (p > 0.05). DTAC was positively correlated with intakes of coffee, whole-grain bread, green vegetables, citrus fruits, and fresh fruit (p /=5 degrees defined as SSP). PA was assessed via validated The Physical Activity Questionnaire for Older Children(PAQ-C) questionnaire[scores 3: vigorous PA(VPA)]. Logistic regression modeled scoliosis risk across PA strata. Restricted cubic splines (RCS) characterized dose-response curves. Subgroup analyses explored age-specific effects. RESULTS: In two multivariable-adjusted models, both LPA and VPA demonstrated significantly elevated risks for SSP compared to MPA (adjusted OR = 3.30, 95% CI 1.92-5.68 and OR = 3.65, 95% CI 2.14-6.24, respectively), revealing a U-shaped dose-response relationship with risk nadir at PAQ-C scores approximately 2.7(p < 0.05). Exercise frequency <3 sessions/week (OR = 4.68, 95% CI 2.75-7.98), session duration < approximately 54 min or >90 min (OR = 3.43 and 2.75), and cumulative participation >2 years (OR = 3.37, 95% CI 1.89-6.01) were positively associated with SSP (p < 0.05). Aquatic sports were inversely associated with SSP(OR = 0.29, 95% CI 0.12-0.71)(p < 0.05). In addition,age-stratified analyses further indicated children (6-11y) exhibited heightened vulnerability to LPA(OR = 5.34, 95% CI 2.62-10.89), both age groups faced elevated risks fromVPA (Children OR = 5.03; Adolescents OR = 3.63), and bilateral sports (e.g., basketball) and aquatic activities universally reduced risk (OR = 0.09-0.19)(p < 0.05). CONCLUSIONS: The amount of physical activity in children and adolescents shows a U-shaped association with SSP, with moderate PA (approximately 54 min/day, 3-4 days/week) being associated with the lowest SSP odds, while low and vigorous PA are associated with higher odds. Participation in water sports and team sports is inversely associated with SSP.These findings highlight potential associations that warrant further longitudinal investigation. CI - (c) 2026 Chen, Yang, Chen and Yuan. FAU - Chen, Chen AU - Chen C AD - School of Physical Education, Sports Kinesiology, Shanghai Normal University, Shanghai, China. AD - Department of Rehabilitation Medicine, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Yang, Yang AU - Yang Y AD - School of Physical Education, Sports Kinesiology, Shanghai Normal University, Shanghai, China. FAU - Chen, Zhen AU - Chen Z AD - Department of Rehabilitation Medicine, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Yuan, Lingyan AU - Yuan L AD - School of Physical Education, Sports Kinesiology, Shanghai Normal University, Shanghai, China. LA - eng PT - Journal Article DEP - 20260514 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13216475 OTO - NOTNLM OT - adolescents OT - children OT - dose-response relationship OT - physical activity OT - scoliosis screening positive COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/01 08:04 MHDA- 2026/06/01 08:05 PMCR- 2026/05/14 CRDT- 2026/06/01 06:00 PHST- 2025/11/27 00:00 [received] PHST- 2026/03/19 00:00 [revised] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/06/01 08:05 [medline] PHST- 2026/06/01 08:04 [pubmed] PHST- 2026/06/01 06:00 [entrez] PHST- 2026/05/14 00:00 [pmc-release] AID - 10.3389/fped.2026.1742234 [doi] PST - epublish SO - Front Pediatr. 2026 May 14;14:1742234. doi: 10.3389/fped.2026.1742234. eCollection 2026. PMID- 42220538 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - miRNA profiling shows shared signatures in pediatric asthma, obesity and their comorbidity. PG - 1792996 LID - 10.3389/fimmu.2026.1792996 [doi] LID - 1792996 AB - RATIONALE: Childhood obesity is a known risk factor for asthma and contributes to increased disease severity and reduced corticosteroid responsiveness. However, the molecular mechanisms underlying this comorbidity remain unclear. Using a cross-sectional design, we aimed to identify microRNA (miRNA) signatures associated with asthma-obesity comorbidity in children to shed light on potential shared molecular drivers. METHODS: Whole blood samples were collected from four pediatric groups: normal weight with asthma (NW-A, n = 11), overweight/obesity with asthma (OO-A, n = 10), overweight/obesity without asthma (OO, n = 10), and normal weight without asthma (NW, n = 12). Circulating miRNA profiles were assessed using the NanoString nCounter platform. Differential expression and pathway enrichment analyses were performed using Enrichr and other bioinformatic tools. Correlation with clinical and cytokine data was assessed by Pearson's correlation and multiple regression analyses. RESULTS: miRNA expression profiles differed markedly across the four groups. Five miRNAs (miR- 423-3p, -92a-3p, -4536-5p, -197-3p, -891a-5p) were consistently upregulated, and two (miR-144-3p, -641) were downregulated across asthma alone, obesity alone, and asthma-obesity comorbidity. Target gene analysis of OO-A-associated miRNAs highlighted involvement in IL-4, IL-13, and PIP3/AKT signaling, as well as pathways linked to innate immunity and metabolism. In OO-A, miRNA dysregulation was correlated with elevated neutrophils, pro-inflammatory cytokines, and reduced lung function. CONCLUSION: In this exploratory study, we identified a shared circulating miRNA signature in asthma-obesity comorbidity. These miRNAs may serve as biomarkers and potential therapeutic targets for stratifying and managing asthma in children with obesity, pending validation in longitudinal studies. CI - Copyright (c) 2026 Shailesh, Djekidel, Noor, Hayati, Worgall, Al Khodor and Janahi. FAU - Shailesh, Harshita AU - Shailesh H AD - Department of Pediatric Medicine, Division of Pulmonology, Sidra Medicine, Doha, Qatar. FAU - Djekidel, Mohamed Nadhir AU - Djekidel MN AD - Research Department, Sidra Medicine, Doha, Qatar. FAU - Noor, Safa AU - Noor S AD - Department of Pediatric Medicine, Division of Pulmonology, Sidra Medicine, Doha, Qatar. FAU - Hayati, Lena AU - Hayati L AD - Department of Pediatric Medicine, Division of Pulmonology, Sidra Medicine, Doha, Qatar. FAU - Worgall, Stefan AU - Worgall S AD - Department of Pediatrics, Weill Cornel Medical College, New York, NY, United States. FAU - Al Khodor, Souhaila AU - Al Khodor S AD - Research Department, Sidra Medicine, Doha, Qatar. FAU - Janahi, Ibrahim AU - Janahi I AD - Department of Pediatric Medicine, Division of Pulmonology, Sidra Medicine, Doha, Qatar. AD - Department of Pediatrics, Weill Cornel Medicine-Qatar (WCM-Q), Doha, Qatar. LA - eng PT - Journal Article DEP - 20260513 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (MicroRNAs) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Asthma/genetics/epidemiology/blood MH - Female MH - Child MH - *MicroRNAs/genetics/blood MH - Gene Expression Profiling MH - Male MH - *Pediatric Obesity/genetics/epidemiology/blood MH - Comorbidity MH - Cross-Sectional Studies MH - Biomarkers MH - *Transcriptome MH - Adolescent PMC - PMC13216767 OTO - NOTNLM OT - asthma OT - biomarkers OT - children OT - miRNA profiling OT - obesity OT - pediatric COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author SK declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/06/01 08:04 MHDA- 2026/06/01 14:26 PMCR- 2026/05/13 CRDT- 2026/06/01 05:56 PHST- 2026/01/21 00:00 [received] PHST- 2026/04/24 00:00 [revised] PHST- 2026/04/27 00:00 [accepted] PHST- 2026/06/01 14:26 [medline] PHST- 2026/06/01 08:04 [pubmed] PHST- 2026/06/01 05:56 [entrez] PHST- 2026/05/13 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1792996 [doi] PST - epublish SO - Front Immunol. 2026 May 13;17:1792996. doi: 10.3389/fimmu.2026.1792996. eCollection 2026. PMID- 42220022 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1108-7161 (Print) IS - 1108-7161 (Linking) VI - 26 IP - 2 DP - 2026 Jun 1 TI - Does a Validated Circum-menarcheal Arm Bone-Loading Index Predict Post-menarcheal Muscle Function in Adolescent Females? PG - 165-180 AB - OBJECTIVE: In this exploratory analysis, we evaluated our validated 3-year circum-menarcheal arm bone loading index (ᴀRᴍBLI) as a predictor of upper extremity muscle function indices in post-menarcheal females. METHODS: Forty-eight participants met inclusion criteria for non-dominant arm analyses, 1 to 2.5 years post-menarche: 1) menarche date (GYNAGE: yrs, menarche-centered age); 2) ᴀRᴍBLI (3-yrs prior loading exposure); 2) grip strength (kg; primary outcome), 3) Biodex peak torques (Nm: shoulder, elbow; flexion, extension; secondary outcomes), 4) DXA arm non-bone fat-free mass (ᴀRᴍNBꜰꜰᴍ, kg), 5) anthropometry [ulna length (mm), height (cm), weight (kg)]. Multiple linear regression evaluated muscle function in the total sample (n=48), gymnasts (n=24), and non-gymnasts (n=24), accounting for key factors: 1) whole-body model (GYNAGE, height, weight, ᴀRᴍBLI); 2) hypertrophy model (GYNAGE, ulna length, ᴀRᴍNBꜰꜰᴍ, ᴀRᴍBLI). RESULTS: After accounting for key factors, ᴀRᴍBLI was an independent negative predictor of grip strength in the total sample [hypertrophy model B= -0.202, p=0.029] and non-gymnast subsample [hypertrophy model B= -0.935, p=0.030; whole-body model B= -1.127, p=0.005]. Conversely, ᴀRᴍBLI was an independent positive predictor of shoulder flexion peak torque in the total sample [whole-body model B= +0.270, p=0.036]. CONCLUSIONS: Despite prior work showing ᴀRᴍBLI predicts ᴀRᴍNBꜰꜰᴍ, ᴀRᴍBLI showed inconsistent predictive value for muscle function indices. FAU - Josephson, Brian AU - Josephson B AD - Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY, USA. FAU - Chan, Timothy AU - Chan T AD - Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY, USA. FAU - Sames, Carol A AU - Sames CA AD - College of Health Professions, SUNY Upstate Medical University, Syracuse, NY, USA. FAU - Scerpella, Tamara A AU - Scerpella TA AD - Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY, USA. AD - Department of Orthopedics & Rehabilitation, University of Wisconsin-Madison, Madison, WI, USA. FAU - Dowthwaite, Jodi N AU - Dowthwaite JN AD - Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY, USA. AD - Department of Orthopedics & Rehabilitation, University of Wisconsin-Madison, Madison, WI, USA. LA - eng PT - Journal Article PL - Greece TA - J Musculoskelet Neuronal Interact JT - Journal of musculoskeletal & neuronal interactions JID - 101084496 SB - IM MH - Humans MH - Female MH - *Muscle, Skeletal/physiology MH - *Menarche/physiology MH - Adolescent MH - *Arm Bones/physiology MH - *Hand Strength/physiology MH - Child PMC - PMC13223780 OTO - NOTNLM OT - Adolescent OT - Exercise OT - Female OT - Grip Strength OT - Peak Torque COIS- The authors have no conflict of interest. EDAT- 2026/06/01 08:04 MHDA- 2026/06/01 08:05 PMCR- 2026/01/01 CRDT- 2026/06/01 03:23 PHST- 2026/06/01 08:05 [medline] PHST- 2026/06/01 08:04 [pubmed] PHST- 2026/06/01 03:23 [entrez] PHST- 2026/01/01 00:00 [pmc-release] AID - JMNI-26-02-165 [pii] AID - 10.22540/JMNI-26-165 [doi] PST - ppublish SO - J Musculoskelet Neuronal Interact. 2026 Jun 1;26(2):165-180. doi: 10.22540/JMNI-26-165. PMID- 42218437 OWN - NLM STAT- MEDLINE DCOM- 20260804 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 May 30 TI - Nutritional status and attitudes toward overweight and obesity among health-science students in Vietnam. LID - 10.1186/s12889-026-27900-5 [doi] LID - 2253 AB - OBJECTIVE: To assess nutritional status across different health-professional disciplines and to examine attitudes toward overweight and obesity and their associated factors among undergraduate health-science students in Vietnam. METHODS: A cross-sectional analytical study was conducted among 764 undergraduate students from medicine, nursing, pharmacy, and other health programs at two universities in Hanoi. Stratified random sampling ensured representation by major and academic year. Nutritional status was classified by BMI using WHO Asian cutoffs. Attitudes toward obesity were measured using the 20-item Attitudes Toward Obese Persons Scale and analyzed in three domains identified by factor analysis. Physical activity, emotional well-being, and resilience were assessed using validated scales. Ordered logistic regression identified predictors of higher BMI category, and Tobit regression examined factors associated with attitude domain scores. RESULTS: Most students had normal BMI, while overweight and obesity were more common in males, in certain living situations, and in general medicine students. Female gender and pharmacy major were associated with lower odds of higher BMI, whereas higher depression scores were associated with higher BMI category. Attitudes toward obesity showed moderate negative stereotypes and relatively positive beliefs. BMI category was associated only with the psychological inferiority domain, with higher scores among students with overweight. Female gender, lower depression, higher happiness and resilience, and moderate physical activity were associated with more favorable attitude profiles. CONCLUSION: Among Vietnamese health-science students, nutritional status and attitudes toward obesity varied across demographic and psychosocial characteristics. Excess weight and weight-related attitudes appear partly independent but influenced by mental well-being and training context. Integrated health promotion and stigma-reduction strategies in health-professional education may improve both student health and future obesity care. CI - (c) 2026. The Author(s). FAU - Khoa, Ngo Xuan AU - Khoa NX AD - Anatomy Department, Hanoi Medical University, Hanoi, 100000, Vietnam. AD - Aesthetic Plastic Surgery Department, Hanoi Medical University Hospital, Hanoi, 100000, Vietnam. FAU - Huy, Vo Tien AU - Huy VT AD - VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi, 100000, Vietnam. FAU - Tuan, Nguyen Xuan AU - Tuan NX AD - VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi, 100000, Vietnam. FAU - Tam, Ngo Thi AU - Tam NT AUID- ORCID: 0000-0003-3987-3135 AD - Institute for Advanced Study in Technology, Ton Duc Thang University, Ho Chi Minh City, 700000, Vietnam. ngothitam@tdtu.edu.vn. AD - Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, 700000, Vietnam. ngothitam@tdtu.edu.vn. FAU - Cham, Tran Linh AU - Cham TL AD - Faculty of Medicine, Dai Nam University, Hanoi, 100000, Vietnam. FAU - Hanh, Hoang Duc AU - Hanh HD AD - Faculty of Medicine, Dai Nam University, Hanoi, 100000, Vietnam. LA - eng PT - Journal Article DEP - 20260530 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Vietnam/epidemiology MH - Male MH - Female MH - Cross-Sectional Studies MH - *Obesity/psychology/epidemiology MH - *Nutritional Status MH - *Overweight/psychology/epidemiology MH - Young Adult MH - *Students, Health Occupations/psychology/statistics & numerical data MH - Adult MH - Body Mass Index MH - Adolescent MH - *Attitude of Health Personnel PMC - PMC13430918 OTO - NOTNLM OT - Body mass index OT - Health-science students OT - Mental well-being OT - Obesity attitudes OT - Vietnam OT - Weight stigma COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki. The study protocol was approved by the Thang Long Institute of Medicine and Pharmacy Research Ethics Committee (Approval code: 01.23/GCN-HDDDNCYSH-IMP). Participants received study information and provided electronic informed consent before participation. Data were collected anonymously and stored securely to ensure confidentiality. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/31 05:33 MHDA- 2026/08/04 06:39 PMCR- 2026/05/30 CRDT- 2026/05/30 23:25 PHST- 2026/03/06 00:00 [received] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/08/04 06:39 [medline] PHST- 2026/05/31 05:33 [pubmed] PHST- 2026/05/30 23:25 [entrez] PHST- 2026/05/30 00:00 [pmc-release] AID - 10.1186/s12889-026-27900-5 [pii] AID - 27900 [pii] AID - 10.1186/s12889-026-27900-5 [doi] PST - epublish SO - BMC Public Health. 2026 May 30;26(1):2253. doi: 10.1186/s12889-026-27900-5. PMID- 42216372 OWN - NLM STAT- MEDLINE DCOM- 20260530 LR - 20260828 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 22 DP - 2026 May 29 TI - Co-sleeping as a contributor to early childhood caries: Behavioral pathways and clinical outcomes. PG - e48384 LID - 10.1097/MD.0000000000048384 [doi] LID - e48384 AB - Early childhood caries (ECC) is a multifactorial chronic disease strongly influenced by feeding behaviors and oral hygiene practices. Co-sleeping is a common caregiving practice that may increase ECC risk by facilitating nocturnal feeding and limiting adequate nighttime oral care. This study aimed to evaluate the association between co-sleeping, related behavioral factors, and the presence and severity of ECC in children aged 1 to 6 years. A retrospective observational study was conducted using clinical and radiographic records from a pediatric dentistry clinic. The sample included 150 children aged 12 to 72 months. Parents completed a validated questionnaire on feeding practices, dietary habits, oral hygiene routines, sugar intake, and co-sleeping behaviors. ECC was assessed using the decayed, missing, and filled teeth index according to World Health Organization criteria. Logistic regression analyses were performed to identify associations between co-sleeping, behavioral variables, and ECC outcomes. Co-sleeping was reported in 18.7% of children. Co-sleeping children showed significantly higher mean decayed, missing, and filled teeth index scores than non-co-sleepers (7.14 vs 3.49). Co-sleeping was significantly associated with nighttime breastfeeding on demand, higher carbohydrate consumption, and inadequate oral hygiene practices (P < .05). In most co-sleeping cases (89.3%), children fell asleep with milk remaining in the oral cavity. Co-sleeping was associated with an approximately 2-fold increase in ECC risk, and behaviors that may increase the risk and severity of ECC, particularly nocturnal feeding and insufficient oral hygiene. Targeted parental education on nighttime feeding and oral care practices may help reduce ECC risk. Prospective studies are warranted to confirm these findings. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Bayon-Hernandez, Gloria AU - Bayon-Hernandez G AD - School of Doctorate, University of Seville, Seville, Spain. AD - Paediatric Dentistry, Faculty of Odontology, University of Seville, Seville, Spain. FAU - Solano-Mendoza, Patricia AU - Solano-Mendoza P AD - Paediatric Dentistry, Faculty of Odontology, University of Seville, Seville, Spain. AD - Coinsol Dental, Sevilla, Spain. FAU - Solano-Mendoza, Beatriz AU - Solano-Mendoza B AUID- ORCID: 0000-0003-4703-2651 AD - Paediatric Dentistry, Faculty of Odontology, University of Seville, Seville, Spain. AD - Coinsol Dental, Sevilla, Spain. FAU - Gomez-Salgado, Juan AU - Gomez-Salgado J AUID- ORCID: 0000-0001-9053-7730 AD - Department of Sociology, Social Work, and Public Health, Faculty of Labour Sciences, University of Huelva, Huelva, Spain. AD - Safety and Health Postgraduate Programme, Universidad Espiritu Santo, Guayaquil, Ecuador. FAU - Fagundo-Rivera, Javier AU - Fagundo-Rivera J AUID- ORCID: 0000-0002-8286-3381 AD - Red Cross University Nursing Centre, University of Seville, Sevilla, Spain. FAU - El Khoury-Moreno, Luis AU - El Khoury-Moreno L AUID- ORCID: 0009-0003-8012-8652 AD - Paediatric Dentistry, Faculty of Odontology, University of Seville, Seville, Spain. FAU - Ribas-Perez, David AU - Ribas-Perez D AUID- ORCID: 0000-0001-6123-9216 AD - Paediatric Dentistry, Faculty of Odontology, University of Seville, Seville, Spain. LA - eng PT - Journal Article PT - Observational Study PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - *Dental Caries/epidemiology/etiology MH - Child, Preschool MH - Female MH - Male MH - *Oral Hygiene MH - Infant MH - *Feeding Behavior MH - Retrospective Studies MH - *Sleep MH - Child MH - Surveys and Questionnaires MH - Risk Factors MH - Breast Feeding PMC - PMC13225582 OTO - NOTNLM OT - breastfeeding habits OT - dental caries risk factors OT - feeding practices OT - nocturnal feeding OT - oral hygiene behaviors OT - pediatric oral health COIS- The authors have no funding and conflicts of interest to disclose. EDAT- 2026/05/30 06:36 MHDA- 2026/05/30 06:37 PMCR- 2026/05/29 CRDT- 2026/05/30 01:01 PHST- 2025/12/04 00:00 [received] PHST- 2026/04/02 00:00 [accepted] PHST- 2026/05/30 06:37 [medline] PHST- 2026/05/30 06:36 [pubmed] PHST- 2026/05/30 01:01 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - 00005792-202605290-00058 [pii] AID - MD-D-25-17402 [pii] AID - 10.1097/MD.0000000000048384 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 May 29;105(22):e48384. doi: 10.1097/MD.0000000000048384. PMID- 42216153 OWN - NLM STAT- MEDLINE DCOM- 20260805 LR - 20260813 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 25 IP - 1 DP - 2026 May 29 TI - Dietary choline intake during pregnancy and birth weight in a Chinese population: a cross-sectional study. LID - 10.1186/s12937-026-01339-1 [doi] LID - 84 AB - BACKGROUND: Previous studies on dietary choline and fetal growth are limited and inconsistent, and the impacts of choline subtypes on fetal growth remain unexplored. We aimed to investigate the associations of maternal intakes of dietary choline and choline subtypes during pregnancy with birth weight, low birth weight (LBW), and small for gestational age (SGA). METHODS: We used a multi-stage stratified cluster random sampling method to recruit 7310 women in Shaanxi China. Maternal diets during pregnancy was collected using a validated food frequency questionnaire. Multilevel linear or logistic regression models were applied to assess the associations. Dose-response relationships were evaluated using restricted cubic spline curves. RESULTS: The mean total choline intake was 331.0 (SD: 162.4) mg/d, and the mean birth weight was 3263.7 (SD: 440.1) g. Each 100 mg increase in total choline, free choline, glycerophosphocholine, phosphocholine, phosphatidylcholine, and sphingomyelin was associated with an increase in birth weight of 18.7 (95% CI = 8.8-28.6), 25.0 (3.4-46.6), 51.1 (0.6-101.7), 128.3 (7.5-249.2), 15.3 (2.2-28.4), and 105.4 (33.5-177.3) g, respectively. Comparing the highest with the lowest tertiles of total choline, phosphatidylcholine, sphingomyelin, glycerophosphocholine, and phosphocholine intakes, participants had lower odds of LBW and SGA, with the ORs for LBW ranging from 0.50 (0.30-0.81) to 0.62 (0.45-0.87) and for SGA from 0.71 (0.57-0.88) to 0.81 (0.68-0.96). There were L-shaped relationships between total choline and choline subtypes intakes and the odds of LBW. CONCLUSIONS: Higher maternal intakes of dietary choline and choline subtypes during pregnancy was associated with higher birth weight and lower odds of LBW and SGA. CI - (c) 2026. The Author(s). FAU - Yang, Jiaomei AU - Yang J AD - Fourth Department of General Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. violetyjm18@xjtu.edu.cn. AD - Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China. violetyjm18@xjtu.edu.cn. AD - Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an, Shaanxi, China. violetyjm18@xjtu.edu.cn. FAU - Xiao, Ziqi AU - Xiao Z AD - Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China. FAU - Hu, Wanting AU - Hu W AD - Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China. FAU - Rekemubieke, Baligen AU - Rekemubieke B AD - Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China. FAU - Li, Yue-Hua AU - Li YH AD - Fourth Department of General Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. liyuehua@xjtu.edu.cn. AD - Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China. liyuehua@xjtu.edu.cn. LA - eng GR - 82103852, 81230016/the National Natural Science Foundation of China/ GR - 2025SF-YBXM-379/Key Research and Development Plan in Shaanxi Province of China/ PT - Journal Article PT - Observational Study DEP - 20260529 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 RN - N91BDP6H0X (Choline) RN - 0 (Phosphatidylcholines) RN - 0 (Sphingomyelins) SB - IM MH - Adult MH - Female MH - Humans MH - Infant, Newborn MH - Pregnancy MH - Young Adult MH - *Birth Weight MH - China MH - *Choline/administration & dosage MH - Cross-Sectional Studies MH - *Diet/methods MH - Infant, Low Birth Weight MH - Infant, Small for Gestational Age MH - Logistic Models MH - *Maternal Nutritional Physiological Phenomena MH - Phosphatidylcholines/administration & dosage MH - Sphingomyelins/administration & dosage PMC - PMC13440090 OTO - NOTNLM OT - Birth weight OT - Choline OT - Free choline OT - Glycerophosphocholine OT - Low birth weight OT - Phosphatidylcholine OT - Phosphocholine OT - Pregnancy OT - Small for gestational age OT - Sphingomyelin COIS- Declarations. Ethics approval and consent to participate: The study adhered to the principles of the Declaration of Helsinki and received approval from the Ethics Committee of Xi'an Jiaotong University Health Science Center (No.2012008). Before the survey, each participant who agreed to participate in the study provided a written consent form. Consent for publication: All authors have read and approved the final manuscript, and agreed to submit it to the Nutrition Journal. Competing interests: The authors declare no competing interests. EDAT- 2026/05/30 00:33 MHDA- 2026/08/05 06:42 PMCR- 2026/05/29 CRDT- 2026/05/29 23:44 PHST- 2025/10/10 00:00 [received] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/08/05 06:42 [medline] PHST- 2026/05/30 00:33 [pubmed] PHST- 2026/05/29 23:44 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - 10.1186/s12937-026-01339-1 [pii] AID - 1339 [pii] AID - 10.1186/s12937-026-01339-1 [doi] PST - epublish SO - Nutr J. 2026 May 29;25(1):84. doi: 10.1186/s12937-026-01339-1. PMID- 42216133 OWN - NLM STAT- MEDLINE DCOM- 20260805 LR - 20260813 IS - 1471-2261 (Electronic) IS - 1471-2261 (Linking) VI - 26 IP - 1 DP - 2026 May 30 TI - Association of plasma ADMA, FABP4 levels, and AIP with increased cardiovascular disease risk in Graves' disease: an exploratory pilot study. LID - 10.1186/s12872-026-06047-6 [doi] LID - 658 AB - BACKGROUND: Graves' disease is an autoimmune disorder characterized by hyperthyroidism and is often associated with diffuse goiter, Graves' ophthalmopathy, antithyroid peroxidase antibodies, TSH receptor antibodies, and high serum thyroxine (T4) and triiodothyronine (T3) levels. Hyperthyroidism causes changes in the cardiovascular system that can be explained by the direct effects of thyroid hormones on vascular smooth muscle cells and cardiomyocytes. On the one hand, heart rate, myocardial contractility, preload, blood volume, and tissue thermogenesis increase, while on the other hand, afterload and systemic vascular resistance decrease. OBJECTIVES: The aim of this exploratory pilot study was to investigate cardiovascular disease risk in patients with Graves' disease by evaluating the relationship between thyroid hormone levels and plasma Asymmetric Dimethylarginine (ADMA), Fatty Acid-Binding Protein 4 (FABP4), Atherogenic Index of Plasma (AIP), and Castelli Risk Index (CRI). METHODS: This study was designed as a cross-sectional study between January 2023 and January 2024 at the Endocrinology and Metabolism Department of Adana City Training and Research Hospital. The study included 30 newly diagnosed patients with Graves' disease, aged 18-65 years, who were recruited from the clinic. The diagnosis was confirmed clinically, biochemically, and through sonographic evaluation. As a control group, 30 euthyroid individuals aged 18-65 years, without thyroid disease, cardiac disease, hypertension, diabetes, or impaired glucose tolerance were selected. Demographic data, including age and gender, were recorded, and Body Mass Index (BMI) was calculated. Blood samples were collected to measure routine parameters such as Thyroid-Stimulating Hormone (TSH), Free Triiodothyronine (fT3), Free Thyroxine (fT4), Thyroid Receptor Antibodies (TRAB), Glucose, Blood Urea Nitrogen (BUN), Creatinine, Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP), HDL, LDL, Total Cholesterol, and Triglycerides. In addition, the levels of ADMA and FABP4 were analyzed. The Atherogenic Index of Plasma (AIP) and Castelli Risk Index (CRI) were calculated. RESULTS: FABP4 levels were significantly higher in patients compared with the control group (10.03 +/- 1.63 vs. 8.99 +/- 1.24, p = 0.009). ADMA was significantly correlated with BMI (r = 0.402, p = 0.019), CRP (r = 0.479, p = 0.001), BUN (r = 0.462, p = 0.003), LDL (r = 0.443, p = 0.012), Total Cholesterol (r = 0.508, p = 0.004), and fT4 (r = 0.455, p = 0.005). Notably, ADMA had a strong positive correlation with FABP4 (r = 0.531, p < 0.001), CRI (r = 0.622, p < 0.001), and AIP (r = 0.642, p < 0.001). FABP4 was positively correlated with BMI (r = 0.514, p = 0.002), glucose (r = 0.577, p < 0.001), and TG (r = 0.614, p < 0.001). CRI was positively correlated with gender (Male) (r = 0.548, p = 0.003), BMI (r = 0.621, p < 0.001), glucose (r = 0.578, p < 0.001), and triglycerides (r = 0.949, p < 0.001). AIP showed a strong positive correlation with TG (r = 0.949, p < 0.001), BMI (r = 0.612, p < 0.001), Glucose (r = 0.576, p < 0.001), and Gender (Male) (r = 0.548, p = 0.003). ADMA demonstrated low discriminatory performance AUC of 0.614, with a cut-off value of > 132.9. It had a sensitivity and specificity of 75%, but the p-value was not significant (p = 0.145). FABP4 had a cut-off of > 8.47, with a sensitivity of 86% and specificity of 68% (AUC: 0.690, 95% CI: 0.551-0.829, p = 0.015). CRI had a cut-off value of > 3.27, with a sensitivity of 60% and specificity of 79% (AUC: 0.726, 95% CI: 0.620-0.832, p = 0.001). AIP showed a cut-off value of > 0.66, with sensitivity of 59% and specificity of 73% (AUC: 0.695, 95% CI: 0.587-0.803, p = 0.001). CONCLUSION: The findings suggest that biomarkers like FABP4, AIP, and CRI may provide insights into cardiovascular risk assessment in Graves' disease. However, further studies with larger cohorts are needed to validate these associations. CI - (c) 2026. The Author(s). FAU - Bulbul, Nese AU - Bulbul N AD - Department of Endocrinology and Metabolism, Gaziantep Islam Science and Technology University, Gaziantep, Turkey. drnesebulbul@yahoo.com.tr. FAU - Yilmaz, Muge Ozsan AU - Yilmaz MO AD - Department of Endocrinology and Metabolism, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey. FAU - Oguzman, Hamdi AU - Oguzman H AD - Department of Medical Biochemistry, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey. FAU - Dogan, Serdar AU - Dogan S AD - Department of Medical Biochemistry, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey. LA - eng PT - Journal Article DEP - 20260530 PL - England TA - BMC Cardiovasc Disord JT - BMC cardiovascular disorders JID - 100968539 RN - 0 (Biomarkers) RN - 0 (Fatty Acid-Binding Proteins) RN - 63CV1GEK3Y (N,N-dimethylarginine) RN - 94ZLA3W45F (Arginine) RN - 0 (FABP4 protein, human) SB - IM MH - Humans MH - Pilot Projects MH - Female MH - Middle Aged MH - Male MH - Adult MH - Biomarkers/blood MH - Cross-Sectional Studies MH - *Fatty Acid-Binding Proteins/blood MH - Heart Disease Risk Factors MH - *Graves Disease/blood/diagnosis/complications MH - Young Adult MH - Adolescent MH - Aged MH - *Arginine/analogs & derivatives/blood MH - Risk Assessment MH - *Cardiovascular Diseases/blood/diagnosis/epidemiology/etiology MH - Risk Factors PMC - PMC13440005 OTO - NOTNLM OT - Asymmetric dimethylarginine OT - Atherogenic Index of Plasma OT - Fatty acid-binding protein 4 OT - Graves' disease OT - cardiovascular disease risk COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Mustafa Kemal University. The Declaration of Helsinki protocol was followed in the research protocol (Approval: 2022/57, Date: 01/11/2022). All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors. Study subjects were recruited only after written informed consent was obtained. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/30 00:32 MHDA- 2026/08/05 06:42 PMCR- 2026/05/30 CRDT- 2026/05/29 23:43 PHST- 2024/11/20 00:00 [received] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/08/05 06:42 [medline] PHST- 2026/05/30 00:32 [pubmed] PHST- 2026/05/29 23:43 [entrez] PHST- 2026/05/30 00:00 [pmc-release] AID - 10.1186/s12872-026-06047-6 [pii] AID - 6047 [pii] AID - 10.1186/s12872-026-06047-6 [doi] PST - epublish SO - BMC Cardiovasc Disord. 2026 May 30;26(1):658. doi: 10.1186/s12872-026-06047-6. PMID- 42214857 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20260924 IS - 1873-7358 (Electronic) IS - 1471-0153 (Print) IS - 1471-0153 (Linking) VI - 62 DP - 2026 Aug TI - Athletes' relationships to training: Validation of an assessment tool across female and male athletes. PG - 102100 LID - S1471-0153(26)00033-4 [pii] LID - 10.1016/j.eatbeh.2026.102100 [doi] AB - OBJECTIVE: Reasons for exercise training are often adaptive (e.g., athletic achievement), but for some athletes, their relationship with training can include a maladaptive desire for weight loss, which can increase risk for eating-disorder pathology. Prior validation of the Athletes' Relationships to Training scale (ART) supported its validity among female athletes. The current study extended this work to compare psychometric properties of the ART among female and male athletes; we expected the measure to perform similarly across sexes. METHODS: We conducted confirmatory factor analyses (CFA) in the full sample and measurement invariance tests separated by self-reported sex in young-adult athletes from three universities (N = 424, 44.3% male, M[SD]age = 18.9[1.3] years). Pearson correlations tested associations among ART scores with other psychological symptoms to evaluate construct validity, and t-tests evaluated mean group differences in ART scores between males and females. RESULTS: The ART's four-factor structure replicated in the full sample, and in males and females separately with good fit. Results from multi-group CFA analyses supported measurement invariance between males and females. There was support for construct validity, such that overall correlations among the ART, maladaptive exercise measures, and eating-disorder pathology were higher relative to correlations with anxiety and depression. Compared to females, males scored significantly higher on the ART total and all subscale scores, with the exception of Body Dissatisfaction. DISCUSSION: Results provided preliminary evidence that the ART can be used to assess maladaptive training behaviors among both male and female young-adult athletes, thereby informing interventions designed to improve exercise motivation. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Chapa, Danielle A N AU - Chapa DAN AD - Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: iversonchapada@upmc.edu. FAU - Hagan, Kelsey E AU - Hagan KE AD - Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: kelsey.hagan@vcuhealth.org. FAU - Brown, Tiffany A AU - Brown TA AD - Department of Psychological Sciences, Auburn University, Auburn, AL, USA. Electronic address: tiffanybrown@auburn.edu. FAU - Harriger, Jennifer A AU - Harriger JA AD - Department of Social Sciences, Pepperdine University, Malibu, CA, USA. Electronic address: jennifer.harriger@pepperdine.edu. FAU - Sanzari, Christina M AU - Sanzari CM AD - Department of Psychology, University at Albany, State University of New York, Albany, NY, USA. Electronic address: csanzari@albany.edu. FAU - Hanss, Kaitlin AU - Hanss K AD - Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA. Electronic address: kaitlin.hanss@ucsf.edu. FAU - Flatt, Rachael E AU - Flatt RE AD - Division of Sports Medicine, Department of Orthopedics and Division of Psychology, Department of Psychiatry, Boston Children's Hospital, Boston, MA, USA. Electronic address: rachaeleflatt@gmail.com. FAU - Forbush, Kelsie T AU - Forbush KT AD - Department of Clinical Child Psychology, University of Kansas, Lawrence, KS, USA; Life Span Institute, University of Kansas, Lawrence, KS, USA. Electronic address: kforbush@ku.edu. FAU - Becker, Carolyn B AU - Becker CB AD - Department of Psychology, Trinity University, San Antonio. TX, USA. Electronic address: cbecker@trinity.edu. FAU - Farrell, Jennifer I AU - Farrell JI AD - Department of Kinesiology, University of North Carolina Greensboro, Greensboro, NC, USA. Electronic address: j_gapin@uncg.edu. FAU - Stewart, Tiffany M AU - Stewart TM AD - Pennington Biomedical Research Center/Louisiana State University, Baton Rouge, LA, USA. Electronic address: tiffany.stewart@pbrc.edu. FAU - Gorrell, Sasha AU - Gorrell S AD - Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA. Electronic address: sasha.gorrell@ucsf.edu. LA - eng GR - K23 MH126201/MH/NIMH NIH HHS/United States GR - T32 MH018269/MH/NIMH NIH HHS/United States GR - R01 AG086777/AG/NIA NIH HHS/United States GR - K12 AR084233/AR/NIAMS NIH HHS/United States GR - R25 MH060482/MH/NIMH NIH HHS/United States GR - R61 MH133710/MH/NIMH NIH HHS/United States PT - Journal Article PT - Validation Study DEP - 20260528 PL - United States TA - Eat Behav JT - Eating behaviors JID - 101090048 SB - IM MH - Humans MH - Male MH - Female MH - *Athletes/psychology MH - Adolescent MH - Psychometrics MH - Young Adult MH - Reproducibility of Results MH - *Exercise/psychology MH - Surveys and Questionnaires MH - Sex Factors MH - Factor Analysis, Statistical MH - Feeding and Eating Disorders/psychology MH - Motivation PMC - PMC13344084 MID - NIHMS2190693 OTO - NOTNLM OT - Athletes OT - College athletes OT - Eating disorders OT - Male athletes OT - Motivation OT - Training COIS- Declaration of competing interest This work received no specific grant from any funding agency, commercial or not-for-profit sectors. Dr. Chapa (T32MH018269), and Dr. Brown (R61MH133710) are supported by the National Institute of Mental Health. Dr. Hagan is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (K12AR084233). Ms. Sanzari is supported by the National Science Foundation Graduate Research Fellowship (Grant No. 1645421). Dr. Becker is supported by the National Institute of Aging (R01AG086777-01). Dr. Stewart is supported by the Department of Defense (HT94252311015) and the Wu Tsai Alliance. EDAT- 2026/05/30 00:33 MHDA- 2026/08/28 23:34 PMCR- 2026/07/09 CRDT- 2026/05/29 19:49 PHST- 2026/02/25 00:00 [received] PHST- 2026/05/26 00:00 [revised] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/08/28 23:34 [medline] PHST- 2026/05/30 00:33 [pubmed] PHST- 2026/05/29 19:49 [entrez] PHST- 2026/07/09 00:00 [pmc-release] AID - S1471-0153(26)00033-4 [pii] AID - 10.1016/j.eatbeh.2026.102100 [doi] PST - ppublish SO - Eat Behav. 2026 Aug;62:102100. doi: 10.1016/j.eatbeh.2026.102100. Epub 2026 May 28. PMID- 42214814 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260728 IS - 1873-1600 (Electronic) IS - 1466-853X (Linking) VI - 80 DP - 2026 Jul TI - Assessing side-to-side injury risk and reliability of the modified landing error scoring system (LESS-M) in youth basketball athletes. PG - 101937 LID - S1466-853X(26)00058-1 [pii] LID - 10.1016/j.ptsp.2026.101937 [doi] AB - OBJECTIVE: To explore the risk of non-contact anterior cruciate ligament (ACL) injury in basketball players, with a specific focus on comparing dominant (DL) and non-dominant limbs (NDL) assessed with the LESS-M and tested the LESS-M reliability. DESIGN: Observational study. SETTING: Field-based testing. PARTICIPANTS: Thirty-six youth basketball players (31 males, 5 females; average BMI 21.35 +/- 1.98 kg/m(2)). MAIN OUTCOME MEASURES: LESS-M total scores of DL and NDL, and intraclass correlation coefficient ICC((2,1)) and ICC((2,k)) reliability. RESULTS: The LESS-M total scores were no statistically significant side-to-side difference (p = 0.327) between DL (4.11 +/- 1.16) and NDL (4.28 +/- 1.36). The LESS-M demonstrated good intra- and inter-rater reliability, with ICC((2,1)) = 0.789 and ICC((2,k)) = 0.803, respectively. CONCLUSION: The risk of non-contact ACL injury assessed using the LESS-M was similar between the DL and NDL in basketball players. The LESS-M demonstrated good reliability and may be a practical screening tool for movement assessment in basketball athletes. Future prospective studies are needed to establish cut-off values and explore its application in injured populations. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Gao, Yu AU - Gao Y AD - Biomechanics and Sports Research Unit, Faculty of Physical Therapy, Mahidol University, Nakhon Pathom, Thailand. FAU - Sinsurin, Komsak AU - Sinsurin K AD - Biomechanics and Sports Research Unit, Faculty of Physical Therapy, Mahidol University, Nakhon Pathom, Thailand. Electronic address: komsak.sin@mahidol.ac.th. FAU - Vachalathiti, Roongtiwa AU - Vachalathiti R AD - Musculoskeletal Physical Therapy Research Unit, Faculty of Physical Therapy, Mahidol University, Nakhon Pathom, Thailand. FAU - Areerak, Kantheera AU - Areerak K AD - Biomechanics and Sports Research Unit, Faculty of Physical Therapy, Mahidol University, Nakhon Pathom, Thailand. FAU - Sondang Irawan, Dimas AU - Sondang Irawan D AD - Physical Therapy Department, Faculty of Health Sciences, University of Muhammadiyah Malang, Malang, Indonesia. LA - eng PT - Journal Article PT - Observational Study DEP - 20260527 PL - England TA - Phys Ther Sport JT - Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine JID - 100940513 SB - IM MH - Humans MH - *Basketball/injuries MH - Reproducibility of Results MH - Female MH - Adolescent MH - *Anterior Cruciate Ligament Injuries/diagnosis MH - Male MH - Risk Assessment/methods MH - *Athletic Injuries MH - Exercise Test OTO - NOTNLM OT - Injury risk assessment OT - Jump landing OT - Lower-limb dominance OT - Movement error OT - Movement screening COIS- Declaration of competing interest The authors declare no conflicts of interest. All authors have read and agreed to the published version of the manuscript. EDAT- 2026/05/30 00:33 MHDA- 2026/07/10 12:46 CRDT- 2026/05/29 19:48 PHST- 2025/10/21 00:00 [received] PHST- 2026/05/18 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/07/10 12:46 [medline] PHST- 2026/05/30 00:33 [pubmed] PHST- 2026/05/29 19:48 [entrez] AID - S1466-853X(26)00058-1 [pii] AID - 10.1016/j.ptsp.2026.101937 [doi] PST - ppublish SO - Phys Ther Sport. 2026 Jul;80:101937. doi: 10.1016/j.ptsp.2026.101937. Epub 2026 May 27. PMID- 42214131 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260611 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 149 DP - 2026 Sep TI - Orthorexia nervosa prevalence and associated factors in individuals attending a diet outpatient clinic: A cross-sectional study. PG - 113258 LID - S0899-9007(26)00166-8 [pii] LID - 10.1016/j.nut.2026.113258 [doi] AB - BACKGROUND: Orthorexia nervosa (ON) is characterized by an excessive preoccupation with consuming healthy foods, which may lead to dietary restrictions, psychological distress, and social isolation. Despite its increasing recognition, ON is not yet formally classified in the diagnostic and statistical manual of mental disorders (DSM), and its prevalence among individuals seeking dietary guidance remains underexplored. This study aims to evaluate the prevalence of orthorexic tendencies and their associated factors among individuals attending a diet outpatient clinic. METHODS: A cross-sectional study was conducted at the Yalova Governmental Hospital Outpatient Diet Polyclinic. A total of 265 participants were recruited using a convenience sampling method. Data were collected through a socio-demographic questionnaire and the ORTO-15 Scale, a widely used tool for assessing ON tendencies. Statistical analyses were performed using SPSS 22.0, with chi-square tests and ANOVA applied to examine relationships between ON and body mass index (BMI). A p-value <.05 was considered statistically significant. In addition, a multivariable logistic regression analysis was conducted to identify factors associated with orthorexic tendencies. RESULTS: The prevalence of orthorexic tendencies among participants was 17%, exceeding the rates reported in the general population. No significant relationship was found between BMI and ON tendencies (p = .27), supporting previous research suggesting that ON is more concerned with food quality than body image. In the multivariable logistic regression analysis, none of the examined variables were significantly associated with orthorexic tendencies. Participants relied primarily on mass media and dietitians for nutritional information, indicating potential influences on dietary behaviors. CONCLUSIONS: This study identified orthorexic tendencies in 17% of individuals attending a diet outpatient clinic, exceeding general population estimates. However, given the psychometric limitations of the ORTO-15, this figure should be interpreted cautiously. No significant sociodemographic or clinical predictors were identified. These findings suggest that orthorexic tendencies may be clinically relevant in dietary settings and highlight the need for validated assessment tools and further research. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Atabay, Fatma Ebru AU - Atabay FE AD - Yalova Governmental Hospital Diet Outpatient Clinic, Yalova, Turkey. FAU - Altin, Duygu AU - Altin D AD - Department of Psychology, University of Amsterdam, Amsterdam, the Netherlands. Electronic address: d.altin@uva.nl. LA - eng PT - Journal Article DEP - 20260502 PL - United States TA - Nutrition JT - Nutrition (Burbank, Los Angeles County, Calif.) JID - 8802712 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Adult MH - Prevalence MH - Male MH - Body Mass Index MH - Young Adult MH - Surveys and Questionnaires MH - *Feeding and Eating Disorders/epidemiology/psychology MH - *Feeding Behavior/psychology MH - Middle Aged MH - Adolescent MH - *Diet, Healthy/psychology MH - Logistic Models MH - *Diet/psychology MH - Ambulatory Care Facilities OTO - NOTNLM OT - Body mass index (BMI) OT - Dietary behavior OT - Eating disorders OT - Healthy eating obsession OT - ORTO-15 scale OT - Orthorexia nervosa COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/30 00:33 MHDA- 2026/06/12 00:38 CRDT- 2026/05/29 18:03 PHST- 2025/06/20 00:00 [received] PHST- 2026/04/20 00:00 [revised] PHST- 2026/04/23 00:00 [accepted] PHST- 2026/06/12 00:38 [medline] PHST- 2026/05/30 00:33 [pubmed] PHST- 2026/05/29 18:03 [entrez] AID - S0899-9007(26)00166-8 [pii] AID - 10.1016/j.nut.2026.113258 [doi] PST - ppublish SO - Nutrition. 2026 Sep;149:113258. doi: 10.1016/j.nut.2026.113258. Epub 2026 May 2. PMID- 42213820 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 1543-5237 (Electronic) IS - 0367-0244 (Linking) VI - 65 IP - 3-4 DP - 2026 Jul TI - Intergenerational Differences in Cultural Capital and Food Promotion Perceptions: Evidence from Urban Indian Families. PG - 171-202 LID - 10.1080/03670244.2026.2674040 [doi] AB - This study examines intergenerational differences in cultural capital and attitudes toward marketing of high-fat, sugar, and salt (HFSS) foods in urban, middle-class Indian households. A survey of parents (n = 218) and co-residing grandparents (n = 40) assessed values, food-related skills, and nutrition knowledge. The questionnaire incorporated validated multi-item scales measuring general human values, social beliefs, and nutrition-related competencies, thereby operationalizing cultural capital across embodied, institutionalized, and objectified dimensions. Parents scored higher on food information skills and sugar and protein knowledge, aligning with health discourse and media literacy. Grandparents relied on traditional caregiving and culinary practices. Drawing the forms of capital framework, findings revealed selective intergenerational contrasts in nutrition literacy and policy receptivity, while awareness of promotional environments remained largely convergent across cohorts, indicating that intergenerational negotiation occurs primarily at the level of interpretive evaluation rather than exposure itself. FAU - Iyer, Kavitha Venkatasubramany AU - Iyer KV AD - Symbiosis Centre for Media and Communication (SCMC), Symbiosis International (Deemed University), Pune, India. LA - eng PT - Journal Article DEP - 20260529 PL - United States TA - Ecol Food Nutr JT - Ecology of food and nutrition JID - 0315073 SB - IM MH - Humans MH - India MH - Female MH - Urban Population MH - Male MH - *Health Knowledge, Attitudes, Practice MH - *Intergenerational Relations MH - Adult MH - *Culture MH - Surveys and Questionnaires MH - Parents MH - Adolescent MH - Middle Aged MH - Grandparents MH - *Diet MH - Marketing MH - Child OTO - NOTNLM OT - Adolescents OT - India OT - family food practices OT - food marketing OT - grandparents OT - intergenerational OT - nutrition knowledge EDAT- 2026/05/29 18:34 MHDA- 2026/07/01 18:34 CRDT- 2026/05/29 14:02 PHST- 2026/07/01 18:34 [medline] PHST- 2026/05/29 18:34 [pubmed] PHST- 2026/05/29 14:02 [entrez] AID - 10.1080/03670244.2026.2674040 [doi] PST - ppublish SO - Ecol Food Nutr. 2026 Jul;65(3-4):171-202. doi: 10.1080/03670244.2026.2674040. Epub 2026 May 29. PMID- 42213130 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260813 IS - 1439-6327 (Electronic) IS - 1439-6319 (Print) IS - 1439-6319 (Linking) VI - 126 IP - 8 DP - 2026 Aug TI - Evaluation of biological and psychometric variables in children and adolescents with intellectual disabilities engaged in aquatic and land-based physical activities. PG - 4593-4605 LID - 10.1007/s00421-026-06195-9 [doi] AB - PURPOSE: The aim of the study was to examine the physiological and psychological responses to aquatic and land-based activities in children and adolescents with intellectual disability (ID) and/or autism spectrum disorder (ASD). METHODS: A total of 30 participants (21 male, 9 female), aged 11.8-18.6 years and diagnosed with ID and/or ASD, completed both a swimming session and a dryland activity session. Anthropometric data, biological maturation, and heart rate (HR) responses were recorded, including the lowest (HRlow), highest (HRhigh), and mean (HRmean) values during activity. Salivary cortisol and alpha-amylase concentrations were measured before and after each session. Participants' enjoyment and preference for physical activity were assessed using the Children's Assessment of Participation and Enjoyment and Preferences for Activities of Children questionnaires. RESULTS: HR responses did not differ significantly between activities. Cortisol decreased significantly following activity (from 0.105 +/- 0.076 to 0.082 +/- 0.076 microg/dL, p = 0.012), while alpha-amylase showed a non-significant decrease (from 157 +/- 101 U/mL to 137 +/- 112 U/mL, p = 0.094). Participants reported greater enjoyment of swimming than land-based activity (4.2 +/- 1.0 vs. 2.5 +/- 1.9, p < 0.001) and expressed a stronger preference for swimming (2.9 +/- 0.4 vs. 2.4 +/- 0.7, p < 0.001). CONCLUSION: Both swimming and land-based activities may serve as moderate-intensity activities that support reductions in physiological and psychological stress in children and adolescents with ID and ASD. Swimming appeared to be more enjoyable and preferred, possibly due to its calming environment and potential to enhance self-efficacy. CI - (c) 2026. The Author(s). FAU - Kyriakidou, Glykeria AU - Kyriakidou G AD - School of Physical Education and Sport Science at Serres, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. FAU - Petridou, Anatoli AU - Petridou A AD - Laboratory of Evaluation of Human Biological Performance, School of Physical Education and Sport Science at Thessaloniki, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. FAU - Giagazoglou, Paraskevi AU - Giagazoglou P AD - School of Physical Education and Sport Science at Serres, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. FAU - Mougios, Vassilis AU - Mougios V AD - Laboratory of Evaluation of Human Biological Performance, School of Physical Education and Sport Science at Thessaloniki, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. FAU - Tsalis, George AU - Tsalis G AD - School of Physical Education and Sport Science at Serres, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. tsalisg@phed-sr.auth.gr. LA - eng PT - Journal Article DEP - 20260529 PL - Germany TA - Eur J Appl Physiol JT - European journal of applied physiology JID - 100954790 RN - WI4X0X7BPJ (Hydrocortisone) RN - EC 3.2.1.1 (alpha-Amylases) SB - IM MH - Humans MH - Adolescent MH - Female MH - Child MH - Male MH - *Intellectual Disability/psychology/physiopathology/metabolism MH - Hydrocortisone/metabolism/analysis MH - Heart Rate/physiology MH - Swimming/psychology/physiology MH - *Exercise/psychology/physiology MH - Saliva/metabolism/chemistry MH - Psychometrics MH - *Autism Spectrum Disorder/psychology/physiopathology MH - alpha-Amylases/metabolism PMC - PMC13451271 OTO - NOTNLM OT - Cognitive impairment OT - Heart rate OT - Maturation OT - Mental retardation OT - Salivary cortisol OT - alpha-amylase COIS- Declarations. Conflict of interest: The authors declare no conflict of interest. Ethical approval: The study was conducted in accordance with the Declaration of Helsinki and approved by the Research Committee of the Aristotle University of Thessaloniki (protocol code: ERC-016/2022). Informed consent: Informed consent was obtained from all subjects involved in the study. EDAT- 2026/05/29 15:41 MHDA- 2026/08/07 12:39 PMCR- 2026/05/29 CRDT- 2026/05/29 11:13 PHST- 2025/10/29 00:00 [received] PHST- 2026/01/11 00:00 [accepted] PHST- 2026/08/07 12:39 [medline] PHST- 2026/05/29 15:41 [pubmed] PHST- 2026/05/29 11:13 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - 10.1007/s00421-026-06195-9 [pii] AID - 6195 [pii] AID - 10.1007/s00421-026-06195-9 [doi] PST - ppublish SO - Eur J Appl Physiol. 2026 Aug;126(8):4593-4605. doi: 10.1007/s00421-026-06195-9. Epub 2026 May 29. PMID- 42213041 OWN - NLM STAT- In-Process LR - 20260529 IS - 1118-4841 (Print) IS - 1118-4841 (Linking) VI - 30 IP - 9s DP - 2026 May 29 TI - Sport participation and menstrual health outcomes among adolescent girls in China: A cross-sectional study. PG - 119-127 LID - (Afr J Reprod Health 2026; 30 [9s]: 119-127). [pii] LID - 10.29063/ajrh2026/v30i9s.11 [doi] AB - Menstrual challenges such as dysmenorrhea, irregular cycles, and premenstrual symptoms are common among adolescent girls, often compromising their overall well-being. Recent studies indicate that sports participation may enhance menstrual health, though quantitative data specific to Chinese adolescents remains limited. This study aimed to examine the connection between sports involvement and menstrual health through a reproductive health lens. Utilizing a cross-sectional design, girls aged 12-18 completed structured questionnaires of 300 people assessing their sports activities, menstrual pain intensity, cycle regularity, premenstrual symptoms, perceived stress levels, and sleep quality. The data were analyzed using descriptive statistics, correlation, and multivariate regression techniques. Results revealed that increased engagement in sports was significantly linked to lower severity of menstrual pain, improved cycle predictability, and reduced premenstrual symptoms. These associations held strong even after adjusting for factors like age, BMI, stress levels, and sleep quality. Reliability across measurement scales ranged from satisfactory to high. This research highlights the positive role of sports participation in enhancing menstrual health among Chinese adolescent girls. Promoting regular and moderate physical activity emerges as an effective strategy to boost reproductive health and overall well-being during adolescence. CI - African Journal of Reproductive Health (c) 2026. FAU - Zhao, Xuanyi AU - Zhao X AD - School of Journalism and Communication, Central China Normal University, China. FAU - Wang, Meilin AU - Wang M AD - School of Marxism, Central China Normal University, China. FAU - Ma, Yinong AU - Ma Y AD - Weifang Institute of Technology, China. LA - eng PT - Journal Article PL - Nigeria TA - Afr J Reprod Health JT - African journal of reproductive health JID - 9712263 SB - IM OTO - NOTNLM OT - China OT - Menstrual Health OT - Reproductive Health OT - Sport Participation COIS- The Authors declared no conflict of interest EDAT- 2026/05/29 15:42 MHDA- 2026/05/29 15:42 CRDT- 2026/05/29 10:43 PHST- 2026/05/29 15:42 [medline] PHST- 2026/05/29 15:42 [pubmed] PHST- 2026/05/29 10:43 [entrez] AID - (Afr J Reprod Health 2026; 30 [9s]: 119-127). [pii] AID - 10.29063/ajrh2026/v30i9s.11 [doi] PST - ppublish SO - Afr J Reprod Health. 2026 May 29;30(9s):119-127. doi: 10.29063/ajrh2026/v30i9s.11. PMID- 42210386 OWN - NLM STAT- MEDLINE DCOM- 20260724 LR - 20260813 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 May 28 TI - Associations of daily sedentary time with mental health and sleep quality in adolescents: analyses of interaction and moderation effects. LID - 10.1186/s40359-026-04877-9 [doi] LID - 1102 AB - BACKGROUND: Prolonged sedentary time and poor mental health are both associated with poorer sleep quality in adolescents, but how they interact to influence sleep quality is unclear. This study examined the interaction between daily sedentary time and mental health on adolescents' sleep quality and assessed the moderating role of mental health. METHODS: This cross-sectional study recruited 10,623 adolescents from 13 schools in Shiyan City, China, from October 2023 to January 2024. Data on demographics (age, sex), daily sedentary time, sleep quality, mental health, and other related factors (e.g., father's smoking status, mode of commuting to school) were collected via self-report questionnaires. Blood pressure was measured using standard protocols. Mental health was assessed with the validated Kessler Psychological Distress Scale, and sleep quality was assessed with the validated Pittsburgh Sleep Quality Index. Multivariate logistic regression was used to examine the associations of daily sedentary time and mental health with sleep quality, as well as the additive and multiplicative interactions between daily sedentary time and mental health on sleep quality. Subsequently, the moderation of the daily sedentary time-sleep quality relationship by mental health was assessed. RESULTS: The prevalence of poor sleep quality was 40.14%. Adolescents with >/= 10 h of daily sedentary time had a higher risk of poor sleep quality (OR = 1.308, 95% CI: 1.169-1.465) than those with < 10 h. Those with poor mental health had a significantly elevated risk (OR = 7.434, 95% CI: 6.535-8.456) compared to those with good mental health. A multiplicative interaction was observed between daily sedentary time and mental health on adolescents' sleep quality (p < 0.05, OR = 0.791, 95% CI: 0.651-0.961), but no additive interaction (RERI = - 0.052, 95% CI: -4.033-3.930; AP = - 0.007, 95% CI : -0.526 - 0.512; S = 0.992, 95% CI : 0.549-1.794). Mental health levels moderated the relationship between daily sedentary time and sleep quality. CONCLUSIONS: Daily sedentary time and mental health were independently associated with sleep quality, and mental health moderated this relationship. These findings suggest that strategies targeting both factors may hold potential for improving adolescent sleep. CI - (c) 2026. The Author(s). FAU - Xiang, Weiwei AU - Xiang W AD - School of Public Health, Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. AD - Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. FAU - Zheng, Lijuan AU - Zheng L AD - School of Public Health, Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. AD - Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. FAU - Zhou, Chenghao AU - Zhou C AD - Department of dermatology, TaiHe Hospital, Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. FAU - Liu, Xiang AU - Liu X AD - Health Management Center, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. FAU - Dai, Li AU - Dai L AD - Dongfeng Stomatological Hospital, Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. FAU - Min, Xinwen AU - Min X AD - Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. FAU - Yang, Handong AU - Yang H AD - Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. FAU - Chen, Jun AU - Chen J AD - Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. FAU - Chen, Jishun AU - Chen J AD - Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. FAU - Li, Dongfeng AU - Li D AD - Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. FAU - Xu, Hao AU - Xu H AD - Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. 18372660141@139.com. FAU - Wu, Wenwen AU - Wu W AD - School of Public Health, Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. wuwenwen108@126.com. AD - Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. wuwenwen108@126.com. AD - Center of Health Administration and Development Studies, Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. wuwenwen108@126.com. LA - eng PT - Journal Article DEP - 20260528 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - *Sedentary Behavior MH - Adolescent MH - Female MH - China/epidemiology MH - Cross-Sectional Studies MH - *Mental Health/statistics & numerical data MH - *Sleep Quality MH - Male PMC - PMC13397720 OTO - NOTNLM OT - Blood pressure OT - Chinese adolescents OT - Daily sedentary time OT - Mental health OT - Sleep quality COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the principles of the Declaration of Helsinki and was approved by the Humanities Research Ethics Committee of the Hubei University of Medicine (Approval No. 2023-RE-027). Permission to conduct the survey was obtained from each school administration. In addition, written informed consent was obtained from all participating students and their legal guardians prior to data collection. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/29 15:45 MHDA- 2026/07/24 06:35 PMCR- 2026/05/28 CRDT- 2026/05/29 00:07 PHST- 2025/10/26 00:00 [received] PHST- 2026/05/22 00:00 [accepted] PHST- 2026/07/24 06:35 [medline] PHST- 2026/05/29 15:45 [pubmed] PHST- 2026/05/29 00:07 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - 10.1186/s40359-026-04877-9 [pii] AID - 4877 [pii] AID - 10.1186/s40359-026-04877-9 [doi] PST - epublish SO - BMC Psychol. 2026 May 28;14(1):1102. doi: 10.1186/s40359-026-04877-9. PMID- 42210272 OWN - NLM STAT- MEDLINE DCOM- 20260805 LR - 20260910 IS - 1741-7015 (Electronic) IS - 1741-7015 (Linking) VI - 24 IP - 1 DP - 2026 May 28 TI - Machine learning and natural language processing for the identification of potential mental disorders among school-age children: a prospective birth cohort study. LID - 10.1186/s12916-026-04927-4 [doi] LID - 413 AB - BACKGROUND: Early identification of childhood mental health disorders is a critical public health objective. Existing screening approaches, largely dependent on observer reports, are resource-intensive and may overlook subtle internalized symptoms. The analysis of children's linguistic expression presents a scalable and potentially more objective alternative. This study evaluates whether combining natural language processing (NLP) of children's essays with conventional risk factors improves the detection of mental health difficulties in school-age populations, relative to models based on a single data source. METHODS: We conducted a prospective analysis using data from the UK-based National Child Development Study (NCDS), a national birth cohort initiated in 1958. Data from birth, age 7, and age 11 assessments were analyzed. The final sample included 8,981 children (4,428 [49.3%] female) who completed a creative writing essay at age 11 describing their imagined life at age 25. Predictors comprised traditional risk factors (perinatal, socioeconomic, and parental engagement variables) and linguistic features computationally extracted from the essays. The primary outcome was potential mental health disorder at age 11, defined as scoring above the 95th or 90th percentile on the teacher-completed Bristol Social Adjustment Guide (BSAG). The mother-completed Rutter A Scale was used for sensitivity analysis. Machine learning models incorporating various predictor combinations were developed, and their predictive performance was evaluated using area under the receiver operating characteristic (AUROC) values. RESULTS: Using BSAG 95th percentile threshold, models combining top five selected variables with essay features achieved significantly higher predictive capability (AUROC:0.77, 95%CI:0.71-0.83) compared to models using all variables (AUROC:0.70, 95%CI:0.63-0.76) or essay features alone (AUROC:0.67, 95%CI:0.60-0.74). At 90th percentile threshold, this integrated approach showed similar improvement (AUROC:0.81, 95%CI:0.78-0.85). Key predictors included gestational length, maternal parity, parental age, residential characteristics, parental engagement metrics, and children's body mass index. Sensitivity analyses using Rutter A Scale confirmed these findings. CONCLUSIONS: In this prospective birth cohort study, integrating NLP analysis of children's essays with a small set of key risk factors substantially improved the identification of potential mental health disorders. This integrated approach represents a potential paradigm for developing scalable, objective screening tools, but requires validation in contemporary, diverse pediatric populations before clinical consideration. CI - (c) 2026. The Author(s). FAU - Chen, Shanquan AU - Chen S AD - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. shanquan.chen@hku.hk. FAU - Dang, Ting AU - Dang T AD - School of Computing and Information Systems, University of Melbourne, Melbourne, VIC, 3010, Australia. FAU - Qian, Mengjie AU - Qian M AD - Department of Engineering, University of Cambridge, Cambridge, CB2 1PZ, UK. FAU - Liang, Huizhi AU - Liang H AD - School of Computing, Newcastle University, Newcastle upon Tyne, UK. FAU - Bedada, Diribsa Tsegaye AU - Bedada DT AD - Department of Health and Rehabilitation Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 7505, South Africa. AD - Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Canada. FAU - Louw, Quinette Abegail AU - Louw QA AD - Department of Health and Rehabilitation Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 7505, South Africa. FAU - Moore, Anna AU - Moore A AD - Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK. FAU - Cardinal, Rudolf N AU - Cardinal RN AD - Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK. AD - Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, CB21 5EF, UK. FAU - Ford, Tamsin J AU - Ford TJ AD - Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK. AD - Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, CB21 5EF, UK. FAU - Jiang, Fan AU - Jiang F AD - School of public health, Shandong ENT Hospital, Shandong University, Jinan, Shandong, China, 250012. Jiang.fan@sdu.edu.cn. LA - eng GR - NIHR203312/NIHR Cambridge Biomedical Research Centre/ GR - 72204143/National Natural Science Foundation of China/ GR - ZR2022QG081/Natural Science Foundation of Shandong Province of China/ GR - MR/Z504816/1/MRC_/Medical Research Council/United Kingdom PT - Journal Article DEP - 20260528 PL - England TA - BMC Med JT - BMC medicine JID - 101190723 SB - IM MH - Humans MH - *Natural Language Processing MH - Female MH - *Machine Learning MH - Prospective Studies MH - Child MH - *Mental Disorders/diagnosis MH - Birth Cohort MH - Male MH - United Kingdom MH - Risk Factors MH - Predictive Learning Models PMC - PMC13439860 OTO - NOTNLM OT - Children OT - Machine learning OT - Mental health screening OT - Natural language processing COIS- Declarations. Ethics approval and consent to participate: This study uses data from the National Child Development Study (NCDS), a nationally representative longitudinal cohort initiated in 1958. Informed consent was obtained for all data collections, with parental consent provided for assessments conducted during childhood, including the age-11 survey and essay-writing task. Formal ethical approval for NCDS follow-ups has been obtained from the UK NHS Multi-Centre Research Ethics Committee (MREC) for all surveys conducted since 2000. Earlier waves, including those in 1958, 1965, 1969, 1974, 1981, and 1991, were conducted prior to the establishment of formal ethics committees or the MREC system. Available documentation indicates that internal ethical review processes were in place for these early waves. For example, the Biomedical Survey and age-55 follow-up were approved by the NHS London-Central Research Ethics Committee (REC) in 2012 (Ref: 12/LO/2010). The current study is a secondary analysis of de-identified public data accessed via the UK Data Service (Study No. 5790). As such, it is exempt from further institutional ethical review, as it does not involve human participants or identifiable private information. Consent for publication: Not applicable. Competing interests: RNC consults for Campden Instruments Ltd; receives royalties from Cambridge University Press, Cambridge Enterprise, and Routledge; and is an unpaid non-executive director of Cambridge University Health Partners. TJF's research group receives funding for methodology consulting from Place2Be, a third sector organisation that provides mental health training and interventions to UK schools. SC and other authors declare no conflict of interest with this work. EDAT- 2026/05/29 15:44 MHDA- 2026/08/05 06:42 PMCR- 2026/05/28 CRDT- 2026/05/29 00:02 PHST- 2025/11/20 00:00 [received] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/08/05 06:42 [medline] PHST- 2026/05/29 15:44 [pubmed] PHST- 2026/05/29 00:02 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - 10.1186/s12916-026-04927-4 [pii] AID - 4927 [pii] AID - 10.1186/s12916-026-04927-4 [doi] PST - epublish SO - BMC Med. 2026 May 28;24(1):413. doi: 10.1186/s12916-026-04927-4. PMID- 42210252 OWN - NLM STAT- MEDLINE DCOM- 20260805 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 May 28 TI - Parents' physical literacy is associated with children's physical activity through parental support. LID - 10.1186/s12889-026-27914-z [doi] LID - 2277 AB - BACKGROUND: Physical activity provides multifaceted physical and mental health benefits for children; however, many children do not achieve the recommended levels. As children spend much of their time with their families, parental support is a key facilitator of physical activity engagement. Physical literacy is related to an individual's physical activity, which may, in turn, affect parental support and, consequently, children's activity levels. Nonetheless, knowledge of how parents' physical literacy relates to parental support and children's activities remains scarce. We aimed to examine the associations between parents' physical literacy, parental support, and children's physical activity. We hypothesized that parents' physical literacy is positively associated with their children's physical activity, directly and indirectly, through supportive behavior. METHODS: In this cross-sectional study, we analyzed data from 2,000 parents (mean age, 40.2 +/- 5.4 years) of children aged 4-9 years from the follow-up survey of the Japan Sports Agency Project for Promoting Physical Activity Habits from Early Childhood. Parents' physical literacy was assessed using the Physical Literacy for Life self-assessment tool, parental support was assessed using five validated items, and children's physical activity was assessed using two parent-reported questions. Structural equation modeling with bootstrapping and bias-corrected confidence intervals (5,000 samples) was used to examine the direct and indirect associations among these variables. RESULTS: Structural equation modeling demonstrated an acceptable model fit (comparative fit index = 0.980, goodness-of-fit index = 0.981, adjusted goodness-of-fit index = 0.968, root mean square error of approximation = 0.047). Parents' physical literacy was positively associated with both parental support (beta = 0.28, p < 0.01) and children's physical activity (beta = 0.09, p < 0.01). Parental support was also associated with children's physical activity (beta = 0.60, p < 0.01). CONCLUSIONS: Parents' physical literacy was positively associated with parental support and children's physical activity, suggesting a mediating role of parental support in this relationship. Enhancing parents' physical literacy may encourage supportive behaviors that contribute to children's physical activity through family-based approaches. CI - (c) 2026. The Author(s). FAU - Matsunaga, Misaki AU - Matsunaga M AD - Juntendo Administration for Sports, Health and Medical Sciences, Juntendo University, Tokyo, Japan. FAU - Matsui, Masahiro AU - Matsui M AD - Faculty of Health and Sports Science, Juntendo University, Chiba, Japan. AD - Department of Child Psychiatry, Yokohama City University Hospital, Kanagawa, Japan. FAU - Toyama, Kenta AU - Toyama K AD - Faculty of Health and Sports Science, Juntendo University, Chiba, Japan. FAU - Someya, Yuki AU - Someya Y AD - Juntendo Administration for Sports, Health and Medical Sciences, Juntendo University, Tokyo, Japan. AD - Faculty of Health and Sports Science, Juntendo University, Chiba, Japan. AD - Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan. FAU - Kawata, Yujiro AU - Kawata Y AD - Faculty of Health and Sports Science, Juntendo University, Chiba, Japan. AD - Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan. AD - Institute of Health and Sports Science & Medicine, Juntendo University, Chiba, Japan. FAU - Kito, Tomonori AU - Kito T AD - Faculty of Health and Sports Science, Juntendo University, Chiba, Japan. AD - Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan. FAU - Nakamura, Emi AU - Nakamura E AD - Juntendo Administration for Sports, Health and Medical Sciences, Juntendo University, Tokyo, Japan. AD - Faculty of Health and Sports Science, Juntendo University, Chiba, Japan. AD - Department of Physical Therapy, Faculty of Health Science, Juntendo University, Tokyo, Japan. FAU - Shoji, Hiromichi AU - Shoji H AD - Juntendo Administration for Sports, Health and Medical Sciences, Juntendo University, Tokyo, Japan. AD - Department of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo, Japan. FAU - Suzuki, Koya AU - Suzuki K AD - Juntendo Administration for Sports, Health and Medical Sciences, Juntendo University, Tokyo, Japan. ko-suzuki@juntendo.ac.jp. AD - Faculty of Health and Sports Science, Juntendo University, Chiba, Japan. ko-suzuki@juntendo.ac.jp. AD - Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan. ko-suzuki@juntendo.ac.jp. AD - Institute of Health and Sports Science & Medicine, Juntendo University, Chiba, Japan. ko-suzuki@juntendo.ac.jp. LA - eng GR - JP25K24347/Japan Society for the Promotion of Science/ GR - JP25K14727/Japan Society for the Promotion of Science/ PT - Journal Article DEP - 20260528 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Child MH - Cross-Sectional Studies MH - *Parents/psychology MH - Female MH - Child, Preschool MH - Male MH - *Exercise/psychology MH - *Parent-Child Relations MH - Family Support MH - *Health Literacy/statistics & numerical data MH - Adult MH - Japan PMC - PMC13439896 OTO - NOTNLM OT - Parental Support OT - Parent-Child Relationship OT - Physical Activity Promotion OT - Physical Literacy OT - Structural Equation Modeling COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the principles of the Declaration of Helsinki. The study was a secondary analysis of data collected from the Japan Sports Agency Project for Promoting Physical Activity Habits from Early Childhood. All participants provided informed consent for the use of their data at the time of the original survey. The secondary analysis of the dataset was approved by the Research Ethics Committee of the Juntendo University School of Health and Sports Science and Graduate School of Health and Sports Science (approval no. 2024-69) with permission from the Japan Sports Agency. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/29 15:46 MHDA- 2026/08/05 06:41 PMCR- 2026/05/28 CRDT- 2026/05/29 00:01 PHST- 2026/01/09 00:00 [received] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/08/05 06:41 [medline] PHST- 2026/05/29 15:46 [pubmed] PHST- 2026/05/29 00:01 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - 10.1186/s12889-026-27914-z [pii] AID - 27914 [pii] AID - 10.1186/s12889-026-27914-z [doi] PST - epublish SO - BMC Public Health. 2026 May 28;26(1):2277. doi: 10.1186/s12889-026-27914-z. PMID- 42207771 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 5 DP - 2026 TI - Physical activity and depressive symptoms among Chinese university students: Grit as a mediator. PG - e0350277 LID - 10.1371/journal.pone.0350277 [doi] LID - e0350277 AB - BACKGROUND: While physical activity is widely recognized for its protective role against depressive symptoms, the specific psychological mechanisms that explain this relationship, particularly among Chinese university students, require further exploration. The present study seeks to clarify whether grit as a hypothesized mediator explaining how physical activity is linked to depressive symptoms severity within this population. METHODS: In this cross-sectional investigation, 3,140 Chinese university students were recruited to complete an online survey. Assessments included demographic variables, physical activity levels, grit, and depressive symptoms, each measured with validated instruments. The hypothesized mediation pathway-wherein grit serves as the mediating variable-was tested via the PROCESS macro for SPSS, with bias-corrected bootstrapping (5,000 resamples) used to assess the indirect effect. RESULTS: Analyses demonstrated a significant negative association between physical activity and depressive symptoms. Crucially, grit was found to completely mediate this association. The indirect pathway through grit was statistically significant (ab = -0.013, 95% CI [-0.016, -0.010]), whereas the direct effect of physical activity was non-significant (c' = -0.002, p > 0.05, 95% CI [-0.011, 0.007]). CONCLUSIONS: These findings indicate that the beneficial effect of physical activity on depressive symptoms is primarily channeled through grit. Intervention strategies aimed at improving mental well-being in this population may be more effective if they combine physical activity promotion with grit-fostering components. CI - Copyright: (c) 2026 Chen, Zhang. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Chen, Yizhou AU - Chen Y AUID- ORCID: 0009-0007-8363-1340 AD - Department of Physical Education, Quzhou University, Quzhou, Zhejiang, China. FAU - Zhang, Jie AU - Zhang J AD - College of Physical Education, Anhui Normal University, Wuhu, Anhui, China. LA - eng PT - Journal Article DEP - 20260528 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Students/psychology MH - *Depression/psychology/epidemiology MH - Universities MH - Female MH - China/epidemiology MH - Young Adult MH - Male MH - *Exercise/psychology MH - Cross-Sectional Studies MH - Adult MH - Adolescent MH - Surveys and Questionnaires PMC - PMC13218493 COIS- The authors have declared that no competing interests exist. EDAT- 2026/05/29 15:44 MHDA- 2026/05/29 15:45 PMCR- 2026/05/28 CRDT- 2026/05/28 13:35 PHST- 2026/01/15 00:00 [received] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/05/29 15:45 [medline] PHST- 2026/05/29 15:44 [pubmed] PHST- 2026/05/28 13:35 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - PONE-D-25-61526 [pii] AID - 10.1371/journal.pone.0350277 [doi] PST - epublish SO - PLoS One. 2026 May 28;21(5):e0350277. doi: 10.1371/journal.pone.0350277. eCollection 2026. PMID- 42207271 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260927 IS - 1432-198X (Electronic) IS - 0931-041X (Print) IS - 0931-041X (Linking) VI - 41 IP - 11 DP - 2026 Nov TI - Development and validation of a cuff size prediction model for pediatric blood pressure measurement outside the office. PG - 3923-3930 LID - 10.1007/s00467-026-07344-0 [doi] AB - BACKGROUND: Mid-arm circumference (AC) is typically measured in person to determine cuff size for ambulatory blood pressure monitoring (ABPM). Our objective was to develop a model to predict cuff size using electronic health record (EHR) data to enable virtual ABPM programs. METHODS: We developed a prediction model for youth 3-21 years in the National Health and Nutrition Examination Survey. Using linear regression, we considered piecewise and polynomial effects of age, sex, height, and weight as predictors of AC. We selected the model with the lowest bootstrapped root-mean-square error (RMSE) and predicted residual error sum of squares with leave-one-out cross-validation. We validated the model in pediatric hypertension clinics at an academic medical center. RESULTS: Based on 34,517 youth in the derivation cohort (median 12 years (25th, 75th percentiles: 7, 16), 49.0% female, 16.6% obesity), the final model included age, age(2), sex, height, weight, weight(2), weight(3), and all possible interactions between age and height and between age and weight (adjusted R(2), 0.97; RMSE, 1.20). In the external validation cohort of 107 youth (median 14 years (25th, 75th percentiles: 10, 17), 35.5% female, 61.7% obesity), observed and predicted AC were highly concordant (⍴(c), 0.94) with mean bias of -0.5 cm (95% limits of agreement, -5.2; 4.1). Overall agreement for the correct cuff size was 87.5% in the derivation cohort (weighted kappa, 0.92) and 83.2% in the validation cohort (weighted kappa, 0.90). CONCLUSIONS: We found substantial agreement between observed and predicted AC using basic EHR data. This model may facilitate ABPM when in-person visits are not feasible. CI - (c) 2026. The Author(s), under exclusive licence to International Pediatric Nephrology Association. FAU - Nugent, James T AU - Nugent JT AUID- ORCID: 0000-0001-9707-5102 AD - Section of Pediatric Nephrology, Department of Pediatrics, Yale School of Medicine, 60 Temple Street, Suite 6C, New Haven, CT, 06510, USA. james.nugent@yale.edu. AD - Section of General Pediatrics, Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA. james.nugent@yale.edu. AD - Clinical and Translational Research Accelerator, Department of Medicine, Yale School of Medicine, New Haven, CT, USA. james.nugent@yale.edu. FAU - Cueto, Victoria AU - Cueto V AD - Section of General Pediatrics, Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA. FAU - Medvecky, Hugh AU - Medvecky H AD - Yale Center for Clinical Investigation, Yale School of Medicine, New Haven, CT, USA. FAU - Harper, Morgan AU - Harper M AD - Section of General Pediatrics, Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA. FAU - Batti, Varshini AU - Batti V AD - Clinical and Translational Research Accelerator, Department of Medicine, Yale School of Medicine, New Haven, CT, USA. FAU - Greenberg, Jason H AU - Greenberg JH AD - Section of Pediatric Nephrology, Department of Pediatrics, Yale School of Medicine, 60 Temple Street, Suite 6C, New Haven, CT, 06510, USA. AD - Clinical and Translational Research Accelerator, Department of Medicine, Yale School of Medicine, New Haven, CT, USA. FAU - Shabanova, Veronika AU - Shabanova V AD - Section of General Pediatrics, Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA. AD - Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA. LA - eng GR - K23 HL177261/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Validation Study DEP - 20260528 PL - Germany TA - Pediatr Nephrol JT - Pediatric nephrology (Berlin, Germany) JID - 8708728 SB - IM MH - Humans MH - Female MH - Adolescent MH - Child MH - *Blood Pressure Monitoring, Ambulatory/instrumentation/methods MH - Child, Preschool MH - Male MH - *Hypertension/diagnosis MH - Young Adult MH - Nutrition Surveys MH - Arm/anatomy & histology MH - Electronic Health Records/statistics & numerical data MH - Blood Pressure MH - Prediction Algorithms MH - Reproducibility of Results PMC - PMC13488455 MID - NIHMS2183132 OTO - NOTNLM OT - Ambulatory blood pressure monitoring OT - Arm circumference OT - Blood pressure OT - Cuff size OT - Hypertension OT - Pediatrics COIS- Declarations. Ethics approval: The study was deemed exempt by the Yale University IRB (HIC #2000033952) because the study was conducted retrospectively from medical record review. Competing interests: The authors declare no competing interests. Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the AHA or NIH. EDAT- 2026/05/28 12:34 MHDA- 2026/09/25 05:31 PMCR- 2026/08/20 CRDT- 2026/05/28 11:14 PHST- 2026/01/17 00:00 [received] PHST- 2026/04/28 00:00 [accepted] PHST- 2026/04/21 00:00 [revised] PHST- 2026/09/25 05:31 [medline] PHST- 2026/05/28 12:34 [pubmed] PHST- 2026/05/28 11:14 [entrez] PHST- 2026/08/20 00:00 [pmc-release] AID - 10.1007/s00467-026-07344-0 [pii] AID - 10.1007/s00467-026-07344-0 [doi] PST - ppublish SO - Pediatr Nephrol. 2026 Nov;41(11):3923-3930. doi: 10.1007/s00467-026-07344-0. Epub 2026 May 28. PMID- 42205619 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260528 LR - 20260813 IS - 2753-4294 (Electronic) IS - 2753-4294 (Linking) VI - 4 IP - 2 DP - 2026 TI - Factors associated with knowledge, attitude and practice of micronutrients among adolescents in Madhyabindu Municipality: a cross-sectional study. PG - e002189 LID - 10.1136/bmjph-2024-002189 [doi] LID - e002189 AB - INTRODUCTION: Micronutrients, which include essential vitamins and minerals required in trace amounts, play crucial roles in various physiological processes, such as immune function, cognitive development and overall health. Several previous studies in Nepal have addressed general nutrition and malnutrition trends, few have specifically explored micronutrient-related knowledge and dietary behaviours, particularly among adolescents with attention given to micronutrients in particular. Therefore, this study aims to assess the level of awareness, perceptions and dietary practices related to micronutrients among adolescents. METHODS: A school-based cross-sectional study was conducted between October and December 2022 among 755 adolescents in Madhyabindu Municipality, Nepal. The study employed multistage random sampling with a validated self-administered questionnaire distributed to participants. Statistical analyses, including chi(2) tests and logistic regression, were performed with significance set at p values <0.05 and <0.001 via the SPSS V.16.0. RESULTS: Adequate knowledge of micronutrient-rich foods was observed in 51.52% of the participants, whereas 47.94% had positive attitudes and 42.38% demonstrated good consumption practices. Higher knowledge levels were linked to higher grades (adjusted OR (AOR)=1.47, 95% CI 0.90 to 2.37), belonging to the advantageous ethnic group (AOR=2.40, 95% CI 1.14 to 3.65), maternal education (primary: AOR=1.91, 95% CI 1.06 to 3.47; secondary: AOR=3.02, 95% CI 1.44 to 6.32) and curriculum nutrition content (AOR=1.92, 95% CI 1.30 to 2.81). Good dietary practices were associated with ethnicity (AOR=3.59, 95% CI 1.89 to 6.79), family income (AOR=2.14, 95% CI 1.18 to 3.86), maternal occupation (AOR=1.73, 95% CI 1.05 to 2.86) and paternal occupation (AOR=1.71, 95% CI 1.01 to 2.90). CONCLUSION: This study highlights a significant gap between adolescents' knowledge and their actual consumption or the dietary practices related to micronutrients. There is a pressing need for targeted educational interventions, particularly those involving parents. Enhancing school curricula to include comprehensive and detailed education on micronutrients-especially folate, zinc and vitamins C and D-is crucial for improving adolescent health outcomes. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. Published by BMJ Group. FAU - Shrestha, Tripti AU - Shrestha T AD - Department of Public Health, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal. FAU - Pokhrel, Poonam AU - Pokhrel P AUID- ORCID: 0009-0002-0974-7664 AD - Department of Public Health, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal. AD - Public Health Arena, Kathmandu, Nepal. AD - Central Department of International Relations and Diplomacy, Tribhuvan University, Kathmandu, Nepal. FAU - Thapa, Milan AU - Thapa M AUID- ORCID: 0009-0004-0148-4956 AD - Public Health Arena, Kathmandu, Nepal. AD - Nepal Health Frontiers, Kathmandu, Bagmati, Nepal. AD - Progress Inc, Maharajgunj, Kathmandu, Nepal. FAU - Paudel, Kiran AU - Paudel K AUID- ORCID: 0000-0002-5590-4133 AD - Nepal Health Frontiers, Kathmandu, Bagmati, Nepal. FAU - Bhusal, Sandesh AU - Bhusal S AUID- ORCID: 0000-0002-3060-5823 AD - Nepal Health Frontiers, Kathmandu, Bagmati, Nepal. FAU - Adhikari, Tara Ballav AU - Adhikari TB AUID- ORCID: 0000-0002-7654-5483 AD - Nepal Health Frontiers, Kathmandu, Bagmati, Nepal. LA - eng PT - Journal Article DEP - 20260522 PL - England TA - BMJ Public Health JT - BMJ public health JID - 9918697578906676 PMC - PMC13202188 OTO - NOTNLM OT - Adolescent OT - Cross-Sectional Studies OT - Public Health COIS- Competing interests: None declared. EDAT- 2026/05/28 06:32 MHDA- 2026/05/28 06:33 PMCR- 2026/05/22 CRDT- 2026/05/28 04:38 PHST- 2024/10/15 00:00 [received] PHST- 2026/04/30 00:00 [accepted] PHST- 2026/05/28 06:33 [medline] PHST- 2026/05/28 06:32 [pubmed] PHST- 2026/05/28 04:38 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - bmjph-2024-002189 [pii] AID - 10.1136/bmjph-2024-002189 [doi] PST - epublish SO - BMJ Public Health. 2026 May 22;4(2):e002189. doi: 10.1136/bmjph-2024-002189. eCollection 2026. PMID- 42205435 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Association between multiple health behaviors and mental health in Chinese college students: a cross-sectional study. PG - 1792272 LID - 10.3389/fpubh.2026.1792272 [doi] LID - 1792272 AB - BACKGROUND: College students face significant psychological pressures, yet the cumulative effects of multiple concurrent health behaviors on their mental health remain underexplored, particularly in the Chinese context. METHODS: A cross-sectional survey was conducted among 521 college students from Shandong and Guangdong provinces, China. Health behaviors, including physical activity (IPAQ-C), sedentary behavior (SBQ), sleep quality (PSQI), smoking, and alcohol use, were assessed via validated self-report questionnaires. Mental health outcomes were measured using the Personal Wellbeing Index (PWI) and the Depression, Anxiety, and Stress Scales-21 (DASS-21). Multiple linear regression analyses, adjusting for key demographic covariates, were employed to examine associations. RESULTS: Prolonged screen time was consistently associated with poorer mental health, showing negative correlations with personal wellbeing (beta = -0.03, P = 0.036) and positive correlations with stress (beta = 0.24, P = 0.030), depression (beta = 0.32, P = 0.005), and anxiety (beta = 0.25, P = 0.020). Alcohol consumption was negatively associated with personal wellbeing (beta = -0.16, P = 0.040). Interestingly, smoking was negatively associated with stress (beta = -1.37, P = 0.020) and depression (beta = -1.44, P = 0.016). Physical activity (MVPA) showed no statistically significant associations with stress (beta = 0.01, P = 0.750), depression (beta = 0.01, P = 0.630), or anxiety (beta = -0.001, P = 0.490) in the regression models. Furthermore, no significant gender differences were observed in the key health behaviors or mental health scores. CONCLUSION: Unhealthy behaviors, particularly high screen time and alcohol use, are significantly associated with adverse mental health outcomes among Chinese college students. The findings suggest that smoking might be used as a maladaptive coping mechanism. Public health interventions should adopt an integrated approach, simultaneously targeting these co-occurring behavioral risk factors to promote student wellbeing. CI - Copyright (c) 2026 Wang, Mu, Liu, Lyu, Liang and Zhou. FAU - Wang, Qingchun AU - Wang Q AD - School of Sport and Health, Shandong Sport University, Jinan, China. FAU - Mu, Liu AU - Mu L AD - School of Graduate Education, Shandong Sport University, Jinan, China. FAU - Liu, Guifang AU - Liu G AD - School of Physical Education, Shenzhen University, Shenzhen, China. FAU - Lyu, Junming AU - Lyu J AD - School of Physical Education, Shenzhen University, Shenzhen, China. FAU - Liang, Wei AU - Liang W AD - School of Physical Education, Shenzhen University, Shenzhen, China. FAU - Zhou, Lin AU - Zhou L AD - School of Sport and Health, Shandong Sport University, Jinan, China. LA - eng PT - Journal Article DEP - 20260512 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Students/psychology/statistics & numerical data MH - Male MH - Female MH - China/epidemiology MH - *Health Behavior MH - *Mental Health/statistics & numerical data MH - Universities MH - Young Adult MH - Alcohol Drinking/epidemiology MH - Smoking/epidemiology MH - Stress, Psychological/epidemiology MH - Exercise/psychology MH - Sedentary Behavior MH - Surveys and Questionnaires MH - Anxiety/epidemiology MH - Adolescent MH - Depression/epidemiology MH - Screen Time MH - Adult MH - Sleep Quality PMC - PMC13201420 OTO - NOTNLM OT - college students OT - health behaviors OT - mental health OT - screen time OT - sedentary behavior COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author WL declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/05/28 06:32 MHDA- 2026/05/28 06:33 PMCR- 2026/05/12 CRDT- 2026/05/28 04:36 PHST- 2026/01/20 00:00 [received] PHST- 2026/04/04 00:00 [revised] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/05/28 06:33 [medline] PHST- 2026/05/28 06:32 [pubmed] PHST- 2026/05/28 04:36 [entrez] PHST- 2026/05/12 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1792272 [doi] PST - epublish SO - Front Public Health. 2026 May 12;14:1792272. doi: 10.3389/fpubh.2026.1792272. eCollection 2026. PMID- 42204355 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260813 IS - 1476-5543 (Electronic) IS - 0743-8346 (Print) IS - 0743-8346 (Linking) VI - 46 IP - 7 DP - 2026 Jul TI - Bedside ultrasound imaging to measure muscle cross-sectional area in preterm and term infants: a feasibility study. PG - 1216-1223 LID - 10.1038/s41372-026-02730-w [doi] AB - BACKGROUND/OBJECTIVE: Lean body mass is linked to improved outcomes, but infant muscle-specific tools are limited. Bedside ultrasound measurements of muscle cross-sectional area (CSA) may overcome these limitations. STUDY DESIGN: A prospective cohort of 60 infants at two neonatal intensive care units (NICUs) underwent serial ultrasound biceps CSA, rectus femoris CSA, and anthropometric measurements. Intraclass correlation coefficients (ICC) assessed measurement reliability. Spline mixed models examined associations between muscle CSA and birth gestational age, growth, postmenstrual age (PMA), and nutrition. RESULTS: Intra- and inter-rater ICCs ranged from 0.92 to 0.99 and from 0.77 to 0.91. No safety events occurred. Biceps CSA correlated with birth gestational age, PMA, weight, length, head circumference, and mid-upper arm circumference (p /=140/90 mmHg). The prevalence was higher among males and those aged >20 years. In the adjusted analyses, males had significantly higher odds of having high BP (AOR: 4.96; 95% CI: 1.64-15.01), as did students from higher-income households (AOR: 3.22; 95% CI: 1.07-9.66). Consumption of high-fat and/or high-salt UPFs at or above the median was independently associated with high BP (AOR: 2.85; 95% CI: 1.16-6.99). Taste, availability, and low cost were common drivers of UPF intake. Conclusions: Higher consumption of high-fat and/or high-salt ultra-processed foods was associated with higher odds of elevated blood pressure among urban young adults. These findings warrant further longitudinal investigation and may help inform the development of targeted dietary awareness and food environment interventions in college settings. FAU - Ramanujam, Karthikeyan AU - Ramanujam K AUID- ORCID: 0000-0002-1970-8696 AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Mahathi, Abhigna AU - Mahathi A AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Pawar, Jarupula Namrathaa AU - Pawar JN AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Matla, Maheshwari AU - Matla M AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Ponnapalli, Harichandana AU - Ponnapalli H AUID- ORCID: 0000-0001-5494-2368 AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Soma, Vinay Kumar AU - Soma VK AUID- ORCID: 0009-0006-5925-658X AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Gajjala, Keerthana AU - Gajjala K AUID- ORCID: 0009-0006-7852-8309 AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Chukkala, SuryaGoud S AU - Chukkala SS AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Mummadi, Mahesh Kumar AU - Mummadi MK AUID- ORCID: 0000-0002-0412-425X AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Gavaravarapu, SubbaRao M AU - Gavaravarapu SM AUID- ORCID: 0000-0003-4524-9646 AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Reddy, G Bhanuprakash AU - Reddy GB AUID- ORCID: 0000-0003-4787-3944 AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Geddam, Jagajeevan Babu AU - Geddam JB AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Reddy, Samarasimha Nusi AU - Reddy SN AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. LA - eng GR - INTR-IG/NIN/02/2023/Indian Council of Medical Research/ PT - Journal Article DEP - 20260520 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Cross-Sectional Studies MH - Female MH - Young Adult MH - Adolescent MH - *Blood Pressure MH - *Hypertension/epidemiology/etiology MH - *Fast Foods/adverse effects MH - India/epidemiology MH - *Feeding Behavior MH - Prevalence MH - Students MH - Odds Ratio MH - Logistic Models MH - Adult MH - *Diet/adverse effects PMC - PMC13209713 OTO - NOTNLM OT - college students OT - hypertension OT - sodium intake OT - ultra-processed foods OT - young adults COIS- The authors declare no competing interests. EDAT- 2026/05/27 06:40 MHDA- 2026/05/27 06:41 PMCR- 2026/05/20 CRDT- 2026/05/27 01:19 PHST- 2026/03/24 00:00 [received] PHST- 2026/04/15 00:00 [revised] PHST- 2026/04/23 00:00 [accepted] PHST- 2026/05/27 06:41 [medline] PHST- 2026/05/27 06:40 [pubmed] PHST- 2026/05/27 01:19 [entrez] PHST- 2026/05/20 00:00 [pmc-release] AID - nu18101617 [pii] AID - nutrients-18-01617 [pii] AID - 10.3390/nu18101617 [doi] PST - epublish SO - Nutrients. 2026 May 20;18(10):1617. doi: 10.3390/nu18101617. PMID- 42197074 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 10 DP - 2026 May 20 TI - Update on Vitamin D Status and Seasonal Variation in a Non-Supplemented Population Living in a High Polluted Urban Area-A Cross-Sectional Study. LID - 10.3390/nu18101614 [doi] LID - 1614 AB - Background: Serum concentrations of 25-hydroxyvitamin D [25(OH)D] are associated with the risk of several chronic and acute diseases. However, updated data on vitamin D status in Mediterranean countries, including Italy, remain limited, hindering effective public health strategies. Objective: To assess serum 25(OH)D levels and their seasonal variation in healthy blood donors aged 18-65 years living in Northern Italy and not taking vitamin D supplements. Given the latitude and the high levels of environmental pollution, cutaneous vitamin D synthesis may be impaired in this population. Recent Italian guidelines on supplementation emphasize the need for updated data on the prevalence of hypovitaminosis D and seasonal variation in endogenous vitamin D synthesis. Methods: In this exploratory retrospective cross-sectional study, 534 blood donors (268 men and 266 women) attending the Transfusion Medicine Unit of the Verona University Hospital were enrolled between April 2016 and May 2018. Serum 25(OH)D concentrations were analyzed by season. Clinical, lifestyle, pharmacological and dietary characteristics were also collected. Results: Among healthy, normal-weight individuals, the prevalence of vitamin D insufficiency (25(OH)D < 50 nmol/L) was low and limited to one-two months per year. Overweight and obesity significantly reduced the likelihood of achieving adequate 25(OH)D levels through cutaneous synthesis for several months. Mean 25(OH)D concentrations were higher than those previously reported in the same area, while seasonal variation remained preserved. Conclusions: In a relatively small non-supplemented population of blood donors living in a high polluted urban area of Northern Italy, seasonal vitamin D synthesis seems to be preserved. These updated data show higher 25(OH)D levels compared to past findings. Although these data certainly warrant further validation through a national survey involving other regions of Italy and in not selected population, they appear to be in line with the SIOMMMS recommendations against indiscriminate serum 25(OH)D testing and against routine supplementation for healthy normal-weight individuals under 70 years. FAU - Bertoldo, Francesco AU - Bertoldo F AUID- ORCID: 0000-0002-5175-7340 AD - Unit of Internal Medicine D, Department of Medicine, University of Verona, 37124 Verona, Italy. FAU - Bortolus, Renata AU - Bortolus R AUID- ORCID: 0000-0003-3857-4133 AD - Office for Research Promotion, Azienda Ospedaliera Universitaria Integrata AOUI Verona, 37126 Verona, Italy. FAU - Filippini, Francesca AU - Filippini F AUID- ORCID: 0000-0001-5884-8635 AD - Office for Research Promotion, Azienda Ospedaliera Universitaria Integrata AOUI Verona, 37126 Verona, Italy. FAU - Chiaffarino, Francesca AU - Chiaffarino F AUID- ORCID: 0000-0001-6009-8108 AD - Gynaecology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy. FAU - Udali, Silvia AU - Udali S AUID- ORCID: 0000-0003-1259-497X AD - Unit of Internal Medicine B, "Epigenomics and Gene-Nutrient Interactions" Laboratory, Department of Medicine, University of Verona, 37124 Verona, Italy. FAU - Rizzi, Monica AU - Rizzi M AD - Unit of Transfusion Medicine, Azienda Ospedaliera Universitaria Integrata AOUI Verona, 37126 Verona, Italy. FAU - Montemezzi, Rachele AU - Montemezzi R AD - Unit of Transfusion Medicine, Azienda Ospedaliera Universitaria Integrata AOUI Verona, 37126 Verona, Italy. FAU - Gandini, Giorgio AU - Gandini G AUID- ORCID: 0000-0002-5574-0714 AD - Unit of Transfusion Medicine, Azienda Ospedaliera Universitaria Integrata AOUI Verona, 37126 Verona, Italy. FAU - Montagnana, Martina AU - Montagnana M AUID- ORCID: 0000-0001-8999-0001 AD - Department of Medicine-DIMED, University of Padua, 35122 Padua, Italy. FAU - Lippi, Giuseppe AU - Lippi G AUID- ORCID: 0000-0001-9523-9054 AD - Section of Clinical Biochemistry, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37124 Verona, Italy. FAU - Moruzzi, Sara AU - Moruzzi S AUID- ORCID: 0009-0009-5016-1113 AD - Unit of Internal Medicine B, "Epigenomics and Gene-Nutrient Interactions" Laboratory, Department of Medicine, University of Verona, 37124 Verona, Italy. FAU - Parazzini, Fabio AU - Parazzini F AUID- ORCID: 0000-0001-5624-4854 AD - Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, 20122 Milan, Italy. FAU - Martinelli, Nicola AU - Martinelli N AUID- ORCID: 0000-0001-6465-5119 AD - Unit of Internal Medicine B, "Epigenomics and Gene-Nutrient Interactions" Laboratory, Department of Medicine, University of Verona, 37124 Verona, Italy. FAU - Lombini, Matteo AU - Lombini M AUID- ORCID: 0000-0001-5813-0391 AD - Unit of Internal Medicine D, Department of Medicine, University of Verona, 37124 Verona, Italy. FAU - De Marchi, Sergio AU - De Marchi S AUID- ORCID: 0000-0001-5775-9614 AD - Unit of Angiology, Department of Medicine, University of Verona, 37124 Verona, Italy. FAU - Pizzolo, Francesca AU - Pizzolo F AUID- ORCID: 0000-0003-4419-3994 AD - Unit of Internal Medicine B, "Epigenomics and Gene-Nutrient Interactions" Laboratory, Department of Medicine, University of Verona, 37124 Verona, Italy. FAU - Friso, Simonetta AU - Friso S AUID- ORCID: 0000-0002-9606-6711 AD - Unit of Internal Medicine B, "Epigenomics and Gene-Nutrient Interactions" Laboratory, Department of Medicine, University of Verona, 37124 Verona, Italy. LA - eng GR - 5587/Bayer (Italy)/ PT - Journal Article DEP - 20260520 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) SB - IM MH - Humans MH - *Seasons MH - Male MH - Cross-Sectional Studies MH - Adult MH - Female MH - Middle Aged MH - *Vitamin D/blood/analogs & derivatives MH - Italy/epidemiology MH - *Vitamin D Deficiency/epidemiology/blood MH - Young Adult MH - Adolescent MH - Retrospective Studies MH - Aged MH - *Urban Population MH - Prevalence MH - *Nutritional Status MH - *Environmental Pollution/adverse effects MH - Blood Donors PMC - PMC13210335 OTO - NOTNLM OT - Italy OT - air pollution OT - seasonality OT - serum sample OT - vitamin D COIS- The authors declare no conflicts of interest. The authors declare that this study received funding from Bayer S.p.A. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/05/27 06:35 MHDA- 2026/05/27 06:36 PMCR- 2026/05/20 CRDT- 2026/05/27 01:19 PHST- 2026/03/31 00:00 [received] PHST- 2026/05/11 00:00 [revised] PHST- 2026/05/13 00:00 [accepted] PHST- 2026/05/27 06:36 [medline] PHST- 2026/05/27 06:35 [pubmed] PHST- 2026/05/27 01:19 [entrez] PHST- 2026/05/20 00:00 [pmc-release] AID - nu18101614 [pii] AID - nutrients-18-01614 [pii] AID - 10.3390/nu18101614 [doi] PST - epublish SO - Nutrients. 2026 May 20;18(10):1614. doi: 10.3390/nu18101614. PMID- 42197048 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 10 DP - 2026 May 16 TI - Eating Disorder Risk and Its Biobehavioural Correlates in Italian University Students: The UniFoodWaste Study. LID - 10.3390/nu18101588 [doi] LID - 1588 AB - Background/Objectives: To assess the prevalence of eating disorder (ED) risk in a sample of Italian university students and to examine its independent associations with mental health indicators, self-rated health, body mass index (BMI), lifestyle behaviours, and engagement with digital food-related applications. Methods: Of the 2779 Italian university students who accessed the survey, 2691 completed and were included in the analysis. ED risk was assessed with the validated 5-item SCOFF questionnaire. Exposure included socio-demographics, BMI, depressive symptoms (PHQ-9), self-rated health, adherence to the Mediterranean diet (Medi-Lite), smoking, alcohol use (AUDIT-C), and use of food delivery and food waste apps. Multivariable logistic regression models, stratified by sex, and adjusted by age and education, estimated associations with ED risk. Results: Overall, 34.6% of participants screened positive for ED risk (women 39.5%, men 21.8%). Smoking and use of food delivery apps and food waste apps were independently associated with ED risk. Clinically relevant depressive symptoms (PHQ-9 >/= 10) (aOR 3.37, 95% CI 2.82-4.02) and poor/fair self-rated health (aOR 2.45, 95% CI 1.93-3.11) showed the strongest association. Overweight (aOR 1.47, 95% CI 1.06-2.03) and obesity (aOR 2.48, 95% CI 1.53-4.01) increased the likelihood of ED risk. Risky alcohol use was also associated (aOR 1.42, 95% CI 1.15-1.75). Conclusions: More than one in three Italian university students is at risk for an ED, highlighting a substantial public health concern. Strong links with depression, perceived poor health, digital food app use, and unhealthy behaviours underscore the need for early screening and integrated mental health and nutrition interventions within university settings. FAU - Pennisi, Flavia AU - Pennisi F AUID- ORCID: 0009-0001-9185-9747 AD - Faculty of Medicine, University Vita-Salute San Raffaele, 20132 Milan, Italy. AD - PhD National Program in One Health Approaches to Infectious Diseases and Life Science Research Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Pinto, Antonio AU - Pinto A AUID- ORCID: 0009-0006-4315-0481 AD - Faculty of Medicine, University Vita-Salute San Raffaele, 20132 Milan, Italy. FAU - Nucci, Daniele AU - Nucci D AUID- ORCID: 0000-0003-4546-213X AD - PhD National Program in One Health Approaches to Infectious Diseases and Life Science Research Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. AD - Struttura Semplice Dipartimentale Igiene Alimenti e Nutrizione, Dipartimento di Igiene e Prevenzione Sanitaria, Agenzia di Tutela Della Salute (ATS) Brescia, Via Duca Degli Abruzzi, 15, 25124 Brescia, Italy. FAU - Stacchini, Lorenzo AU - Stacchini L AUID- ORCID: 0000-0002-7405-4904 AD - Department of Community Healthcare Network, Health District "Toscana ASL Nord Ovest", Pisa, Via Fleming 1, 56025 Pontedera, Italy. FAU - Garzitto, Marco AU - Garzitto M AUID- ORCID: 0000-0001-7565-420X AD - Unit of Psychiatry, Department of Medicine (DMED), University of Udine, 33100 Udine, Italy. FAU - Veronese, Nicola AU - Veronese N AUID- ORCID: 0000-0002-9328-289X AD - Faculty of Medicine, Saint Camillus International University of Health Sciences, 00131 Rome, Italy. FAU - Maggi, Stefania AU - Maggi S AUID- ORCID: 0000-0002-0453-8663 AD - Institute of Neuroscience, Aging Unit, National Research Council, 35127 Padova, Italy. FAU - Signorelli, Carlo AU - Signorelli C AUID- ORCID: 0000-0002-0960-9563 AD - Faculty of Medicine, University Vita-Salute San Raffaele, 20132 Milan, Italy. FAU - Baldo, Vincenzo AU - Baldo V AUID- ORCID: 0000-0001-6012-9453 AD - Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padua, 35128 Padua, Italy. FAU - Colizzi, Marco AU - Colizzi M AUID- ORCID: 0000-0001-6139-1920 AD - Unit of Psychiatry, Department of Medicine (DMED), University of Udine, 33100 Udine, Italy. AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK. FAU - Gianfredi, Vincenza AU - Gianfredi V AUID- ORCID: 0000-0003-3848-981X AD - Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padua, 35128 Padua, Italy. LA - eng GR - PSR-LINEA2-2022/University of Milan/ PT - Journal Article DEP - 20260516 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Italy/epidemiology MH - Male MH - *Students/psychology/statistics & numerical data MH - Universities MH - Young Adult MH - Risk Factors MH - *Feeding and Eating Disorders/epidemiology/psychology MH - Adult MH - Adolescent MH - Prevalence MH - Surveys and Questionnaires MH - Depression/epidemiology MH - Body Mass Index MH - Life Style MH - Cross-Sectional Studies MH - Mental Health PMC - PMC13209805 OTO - NOTNLM OT - Italy OT - digital food environment OT - eating disorders OT - lifestyle factors OT - mental health OT - university students COIS- The authors declare the following financial interests/personal relationships, which may be considered as potential competing interests: Marco Colizzi reports honoraria from Janssen-Cilag S.p.A. and Epitech Group S.p.A. for scientific communication and outreach activities and has served as a consultant/advisor for GW Pharma Limited, F. Hoffmann-La Roche Limited, GW Pharma Italy S.r.l., Idorsia Pharmaceuticals Italy S.r.l., and Insights Driven Research (IDR); Vincenza Gianfredi reports that financial support was provided by the University of Milan. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article. EDAT- 2026/05/27 06:38 MHDA- 2026/05/27 06:39 PMCR- 2026/05/16 CRDT- 2026/05/27 01:19 PHST- 2026/04/07 00:00 [received] PHST- 2026/05/07 00:00 [revised] PHST- 2026/05/13 00:00 [accepted] PHST- 2026/05/27 06:39 [medline] PHST- 2026/05/27 06:38 [pubmed] PHST- 2026/05/27 01:19 [entrez] PHST- 2026/05/16 00:00 [pmc-release] AID - nu18101588 [pii] AID - nutrients-18-01588 [pii] AID - 10.3390/nu18101588 [doi] PST - epublish SO - Nutrients. 2026 May 16;18(10):1588. doi: 10.3390/nu18101588. PMID- 42197036 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 10 DP - 2026 May 15 TI - Influence of Parental Lifestyle and Dietary Patterns on Mediterranean Diet Adherence in Children and Adolescents: A Cross-Sectional Study. LID - 10.3390/nu18101576 [doi] LID - 1576 AB - Background/Objectives: Adherence to the Mediterranean diet (MD) is associated with reduced risk of non-communicable diseases but has declined among children, even in traditionally high-adherence settings such as Greece. As parental lifestyle behaviors strongly influence children's dietary patterns, this study examined the associations between parental lifestyle factors and children's MD adherence in Crete, Greece. Methods: A total of 760 parent-child dyads participated in this cross-sectional study. Children's adherence to the MD was assessed using the KIDMED index. Parents completed validated instruments, including the MEDAS (MD adherence), IPAQ (physical activity), PSQI (sleep quality), and NLS (nutrition literacy), along with questions on dietary habits and screen time behaviors. ANOVA/Kruskal-Wallis tests and multivariable linear regression identified predictors of KIDMED scores. Results: Mean KIDMED score was 5.95 +/- 2.65; 32% achieved optimal adherence. Younger children showed higher adherence. Higher children's adherence to MD was positively associated with parental MD adherence (beta = 0.493), urban residence (beta = 0.544), higher parental education (beta = 0.493), consistent daily meal routines (breakfast and mid-morning and mid-afternoon snacks), higher water intake, and fresh juice consumption (all p < 0.05) were positively associated with parental MD adherence. Conversely, lower adherence was associated with parental age >/= 45 years (beta = 0.987), higher parental BMI (beta = 0.072), consumption of sugar-sweetened (beta = 0.390) or artificially sweetened beverages (beta = 0.497), and weekend screen time >/= 3 h/day (beta = 0.383) (all p < 0.05). Conclusions: Children's adherence to the MD is strongly associated with parental dietary behaviors and structured meal routines. These findings support family-focused interventions that emphasize parental dietary role modeling to counter declining MD adherence among Mediterranean youth. FAU - Peraki, Sevasti AU - Peraki S AUID- ORCID: 0009-0004-1516-7126 AD - Department of Social Medicine, School of Medicine, University of Crete, 71500 Heraklion, Greece. FAU - Bouloukaki, Izolde AU - Bouloukaki I AUID- ORCID: 0000-0001-5903-3550 AD - Department of Social Medicine, School of Medicine, University of Crete, 71500 Heraklion, Greece. FAU - Christodoulakis, Antonios AU - Christodoulakis A AUID- ORCID: 0000-0003-0544-851X AD - Department of Social Medicine, School of Medicine, University of Crete, 71500 Heraklion, Greece. FAU - Vavoulas, Dimitrios AU - Vavoulas D AUID- ORCID: 0009-0007-3077-1585 AD - Department of Social Medicine, School of Medicine, University of Crete, 71500 Heraklion, Greece. FAU - Tsiligianni, Ioanna AU - Tsiligianni I AUID- ORCID: 0000-0001-7922-7491 AD - Department of Social Medicine, School of Medicine, University of Crete, 71500 Heraklion, Greece. AD - Department of Primary Care and Population Health, Medical School, University of Nicosia, 2417 Nicosia, Cyprus. LA - eng PT - Journal Article DEP - 20260515 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Diet, Mediterranean MH - Cross-Sectional Studies MH - Male MH - Female MH - Child MH - Greece MH - *Life Style MH - Adolescent MH - *Parents/psychology MH - *Feeding Behavior MH - Parent-Child Relations MH - *Patient Compliance MH - Child Behavior PMC - PMC13209914 OTO - NOTNLM OT - KIDMED OT - Mediterranean diet OT - adolescents OT - child obesity OT - dietary patterns OT - family environment OT - health behaviors OT - lifestyle behaviors OT - parents OT - pediatric nutrition COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 06:41 MHDA- 2026/05/27 06:42 PMCR- 2026/05/15 CRDT- 2026/05/27 01:19 PHST- 2026/04/08 00:00 [received] PHST- 2026/05/14 00:00 [revised] PHST- 2026/05/14 00:00 [accepted] PHST- 2026/05/27 06:42 [medline] PHST- 2026/05/27 06:41 [pubmed] PHST- 2026/05/27 01:19 [entrez] PHST- 2026/05/15 00:00 [pmc-release] AID - nu18101576 [pii] AID - nutrients-18-01576 [pii] AID - 10.3390/nu18101576 [doi] PST - epublish SO - Nutrients. 2026 May 15;18(10):1576. doi: 10.3390/nu18101576. PMID- 42196959 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 10 DP - 2026 May 8 TI - Emotional Influences on Eating Behavior and Hunger Awareness Among Generation Z University Students in Greece. LID - 10.3390/nu18101500 [doi] LID - 1500 AB - BACKGROUND: Emotional determinants of eating behavior are increasingly recognized as critical components of behavioral nutrition, particularly among Generation Z, a population characterized by heightened emotional reactivity and rapidly shifting dietary patterns. OBJECTIVES: This cross-sectional study examined the multidimensional structure of emotional influences on eating behavior among 411 university students in Greece and explored which emotional mechanisms are most closely associated with emotional hunger awareness. METHODS: Using the Emotional Influence on Eating Behavior Questionnaire (EIEBQ), four constructs were assessed. Exploratory Factor Analysis supported a refined four-factor structure explaining 63.23% of variance, following the removal of one low-communality item. RESULTS: Participants reported moderate emotional undereating (M = 3.17) and reduced enjoyment of food under emotional distress (M = 3.38), lower reliance on food for emotional overeating (M = 2.86), and high emotional awareness (M = 3.76). Regression analyses, although explaining a small proportion of variance (R(2) = 0.042), indicated that emotional undereating (beta = 0.155, p = 0.017) and emotional overeating (beta = 0.135, p = 0.027) were the most consistent predictors of emotional hunger awareness. CONCLUSIONS: These findings suggest that emotional responses-rather than cognitive appraisal-may play a meaningful role in distinguishing emotional from physical hunger. By providing an initial psychometric evaluation and a behavior-focused framework, this study offers preliminary insights into emotional eating mechanisms among Generation Z university students and contributes to the development of targeted interventions promoting healthier and more sustainable dietary behaviors. FAU - Koliou, Maria P AU - Koliou MP AUID- ORCID: 0009-0009-1751-5629 AD - Laboratory of Food Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece. FAU - Karaiskou, Chrysoula AU - Karaiskou C AD - Sidroco Holdings Ltd., Nicosia 1082, Cyprus. FAU - Eleftheriadis, Charalampos AU - Eleftheriadis C AUID- ORCID: 0000-0002-0726-4127 AD - Sidroco Holdings Ltd., Nicosia 1082, Cyprus. FAU - Kontogeorgos, Achilleas AU - Kontogeorgos A AUID- ORCID: 0000-0002-4186-0379 AD - Department of Agriculture, International University of Greece, 57001 Thessaloniki, Greece. FAU - Skalkos, Dimitris AU - Skalkos D AUID- ORCID: 0000-0002-7771-2845 AD - Laboratory of Food Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece. LA - eng PT - Journal Article DEP - 20260508 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Greece MH - Female MH - *Students/psychology MH - *Hunger MH - *Feeding Behavior/psychology MH - Universities MH - Cross-Sectional Studies MH - Male MH - Young Adult MH - *Emotions MH - Surveys and Questionnaires MH - Emotional Eating MH - Adult MH - Adolescent MH - Awareness MH - Hyperphagia/psychology PMC - PMC13209663 OTO - NOTNLM OT - Generation Z OT - behavioral nutrition OT - eating behavior OT - emotional awareness OT - emotional eating OT - emotional hunger OT - emotional regulation OT - food enjoyment OT - overeating OT - undereating COIS- C.K. and C.E. were employed by Sidroco Holdings Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/27 06:34 MHDA- 2026/05/27 06:35 PMCR- 2026/05/08 CRDT- 2026/05/27 01:19 PHST- 2026/04/17 00:00 [received] PHST- 2026/04/30 00:00 [revised] PHST- 2026/05/06 00:00 [accepted] PHST- 2026/05/27 06:35 [medline] PHST- 2026/05/27 06:34 [pubmed] PHST- 2026/05/27 01:19 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - nu18101500 [pii] AID - nutrients-18-01500 [pii] AID - 10.3390/nu18101500 [doi] PST - epublish SO - Nutrients. 2026 May 8;18(10):1500. doi: 10.3390/nu18101500. PMID- 42195133 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1648-9144 (Electronic) IS - 1010-660X (Print) IS - 1010-660X (Linking) VI - 62 IP - 5 DP - 2026 May 4 TI - Sleep Quality and Associated Lifestyle Factors Among Medical Students Before and After the COVID-19 Era-A Comparative Study from Romania. LID - 10.3390/medicina62050880 [doi] LID - 880 AB - Background and Objectives: Sleep is a vital psychological function for health and well-being in all age groups, from children to adolescents, to adults and the elderly, and impacts quality of life. This study evaluated temporal changes in sleep quality and lifestyle behaviors among medical students in North-Western Romania (Transylvania) between the COVID-19 pandemic and the post-pandemic period. Materials and Methods: A cross-sectional design was employed involving 709 medical students assessed during the first pandemic wave (2020) and the 2023-2024 academic year. Online questionnaires collected data on demographics, body mass index (BMI), substance use, and physical activity. Sleep quality was measured using the validated Athens Insomnia Scale (AIS), and multiple linear regression was performed to identify predictors of sleep outcomes. Results: Post-pandemic data revealed a significant decline in sleep quality, with female gender and lower academic performance identified as significant predictors of insomnia symptoms (R(2) of 0.258, p < 0.05). While physical activity levels improved significantly in 2024 compared to the confinement period, this was accompanied by increased fast-food consumption and a rise in overweight and obesity rates. Conversely, illicit drug use decreased, and alcohol consumption patterns shifted, characterized by reduced weekly frequency among females but persistent binge drinking episodes. Conclusions: The transition to post-pandemic education yielded mixed health outcomes; while physical activity rebounded, sleep quality and nutritional status deteriorated. These findings highlight the necessity for university-based interventions focusing on sleep hygiene, nutrition, and stress management to support the well-being of medical students. FAU - Nasui, Bogdana Adriana AU - Nasui BA AUID- ORCID: 0000-0001-5682-0225 AD - Department of Community Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. AD - Research Center in Preventive Medicine, Health Promotion and Sustainable Development, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. FAU - Gorgan, Lorena AU - Gorgan L AD - Department of Community Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. FAU - Popescu, Codruta Alina AU - Popescu CA AUID- ORCID: 0000-0002-3691-8871 AD - Department of Human Sciences, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania. FAU - Ciuciuc, Nina AU - Ciuciuc N AUID- ORCID: 0000-0001-5504-7031 AD - Department of Community Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. AD - Research Center in Preventive Medicine, Health Promotion and Sustainable Development, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. FAU - Rosioara, Alexandra-Ioana AU - Rosioara AI AUID- ORCID: 0000-0002-8914-8137 AD - Department of Community Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. AD - Research Center in Preventive Medicine, Health Promotion and Sustainable Development, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. FAU - Sirbu, Dana Manuela AU - Sirbu DM AUID- ORCID: 0009-0001-0514-5829 AD - Department of Community Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. AD - Research Center in Preventive Medicine, Health Promotion and Sustainable Development, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. FAU - Popa, Monica AU - Popa M AD - Department of Community Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. AD - Research Center in Preventive Medicine, Health Promotion and Sustainable Development, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. FAU - Curseu, Daniela AU - Curseu D AD - Department of Community Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. AD - Research Center in Preventive Medicine, Health Promotion and Sustainable Development, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. FAU - Borda, Ileana Monica AU - Borda IM AUID- ORCID: 0000-0002-6337-8831 AD - Department of Medical Specialties, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania. FAU - Ungur, Rodica Ana AU - Ungur RA AD - Department of Medical Specialties, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260504 PL - Switzerland TA - Medicina (Kaunas) JT - Medicina (Kaunas, Lithuania) JID - 9425208 SB - IM MH - Humans MH - Romania/epidemiology MH - Female MH - Male MH - *Sleep Quality MH - *Students, Medical/psychology/statistics & numerical data MH - *Life Style MH - Cross-Sectional Studies MH - *COVID-19/epidemiology/psychology MH - Adult MH - Surveys and Questionnaires MH - Young Adult MH - Sleep Initiation and Maintenance Disorders/epidemiology MH - Exercise MH - Quality of Life MH - SARS-CoV-2 PMC - PMC13209030 OTO - NOTNLM OT - alcohol consumption OT - diet OT - illicit drugs OT - lifestyle choices OT - nutritional status OT - physical activity OT - risky behaviors OT - sleep quality OT - students OT - wellbeing COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 06:33 MHDA- 2026/05/27 06:34 PMCR- 2026/05/04 CRDT- 2026/05/27 01:12 PHST- 2026/03/08 00:00 [received] PHST- 2026/04/16 00:00 [revised] PHST- 2026/04/20 00:00 [accepted] PHST- 2026/05/27 06:34 [medline] PHST- 2026/05/27 06:33 [pubmed] PHST- 2026/05/27 01:12 [entrez] PHST- 2026/05/04 00:00 [pmc-release] AID - medicina62050880 [pii] AID - medicina-62-00880 [pii] AID - 10.3390/medicina62050880 [doi] PST - epublish SO - Medicina (Kaunas). 2026 May 4;62(5):880. doi: 10.3390/medicina62050880. PMID- 42194659 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260527 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 10 DP - 2026 May 11 TI - Relative Trunk Adipopenia Is Associated with the Severity of Liver Disease and Outcome in Patients with Cirrhosis. LID - 10.3390/jcm15103697 [doi] LID - 3697 AB - Background/Objectives: Regional adipose tissue has been studied as a prognostic factor in various extra-hepatic diseases, but data in the setting of cirrhosis is scarce. Our aim was to evaluate the association of regional adipose tissue indices with the severity of liver disease and its impact on the outcome of patients with cirrhosis. Methods: Three hundred and thirty-seven patients with cirrhosis were prospectively enrolled in the study. Clinical and laboratory data were recorded, and MELD-Na and Child-Turcotte-Pugh scores were calculated. Physical performance was evaluated with handgrip strength, the Short Physical Performance Battery test, and the Liver Frailty Index. Dual-energy X-ray absorptiometry was used for the evaluation of total and regional lean and fat mass. Results: A low trunk fat percentage was found to be independently associated with a MELD-Na score >/= 15 (Odds Ratio: 0.92, p = 0.007). MELD-Na score and trunk fat percentage were the only factors independently associated with mortality [Hazard Ratio (HR): 1.078, p = 0.02 and HR: 0.95, p = 0.03, respectively], while a separate analysis based on gender confirmed this finding only in men. In the total cohort, patients with a trunk fat percentage < 27.5% had worse outcomes (log-rank 11.4; p < 0.001). Conclusions: This study marks the first effort to examine the association of indices related to regional adipose tissue distribution with the severity of liver disease and outcome. Trunk fat percentage was the only body composition parameter independently associated with advanced liver disease and prognosis in the total cohort specifically in men, but not in women. Further studies are needed to validate the predictive role of adipose tissue in patients with cirrhosis. FAU - Kamiliou, Aikaterini AU - Kamiliou A AUID- ORCID: 0009-0009-7254-4617 AD - First Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Adamantou, Magdalini AU - Adamantou M AUID- ORCID: 0009-0000-3306-050X AD - First Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Pergantina, Eleni AU - Pergantina E AD - First Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Rachiotis, Nikolaos AU - Rachiotis N AD - First Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Bali, Triada AU - Bali T AD - First Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Mouziouras, Dimitrios AU - Mouziouras D AD - First Department of Gastroenterology, General Hospital of Athens "Laiko", Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Lakiotaki, Dimitra AU - Lakiotaki D AD - First Department of Gastroenterology, General Hospital of Athens "Laiko", Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Lekakis, Vasileios AU - Lekakis V AUID- ORCID: 0000-0002-6105-4147 AD - First Department of Gastroenterology, General Hospital of Athens "Laiko", Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Alexopoulou, Alexandra AU - Alexopoulou A AD - Second Department of Internal Medicine, "Hippokration" General Hospital of Athens, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Papatheodoridis, George V AU - Papatheodoridis GV AUID- ORCID: 0000-0002-3518-4060 AD - First Department of Gastroenterology, General Hospital of Athens "Laiko", Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Cholongitas, Evangelos AU - Cholongitas E AUID- ORCID: 0000-0002-3645-582X AD - First Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. AD - First Department of Gastroenterology, General Hospital of Athens "Laiko", Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. LA - eng PT - Journal Article DEP - 20260511 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13207654 OTO - NOTNLM OT - adipopenia OT - adipose tissue OT - body composition OT - end-stage liver disease OT - fat OT - frailty OT - liver transplantation OT - prognosis OT - sarcopenia COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 06:39 MHDA- 2026/05/27 06:40 PMCR- 2026/05/11 CRDT- 2026/05/27 01:10 PHST- 2026/03/27 00:00 [received] PHST- 2026/05/04 00:00 [revised] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/05/27 06:40 [medline] PHST- 2026/05/27 06:39 [pubmed] PHST- 2026/05/27 01:10 [entrez] PHST- 2026/05/11 00:00 [pmc-release] AID - jcm15103697 [pii] AID - jcm-15-03697 [pii] AID - 10.3390/jcm15103697 [doi] PST - epublish SO - J Clin Med. 2026 May 11;15(10):3697. doi: 10.3390/jcm15103697. PMID- 42194591 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260527 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 10 DP - 2026 May 9 TI - Growth Patterns and Factors Associated with Short Stature in Saudi Children and Adolescents with Type 1 Diabetes Mellitus: A Retrospective Cross-Sectional Study. LID - 10.3390/jcm15103629 [doi] LID - 3629 AB - Background: The impact of Type 1 Diabetes Mellitus (T1DM) on linear growth in children remains unclear, with conflicting evidence regarding the roles of glycemic control, disease duration, and nutritional factors. This study aimed to assess growth patterns and identify factors independently associated with short stature among Saudi school-age children and adolescents with T1DM, comparing them to a healthy control group. Methods: A retrospective cross-sectional study was conducted at an endocrinology clinic, including 250 patients with T1DM aged 5-18 years and 267 healthy controls. After propensity score matching, 231 patients were matched to 231 controls. Data were extracted from electronic medical records using a standardized form. Anthropometric measurements were converted to Z-scores and percentiles using validated Saudi growth charts. Short stature was defined as height below the third percentile for age and gender. Univariate and multivariable logistic regression analyses were performed to identify factors associated with short stature among T1DM participants. Results: The median age of the 250 T1DM participants was 13.0 [10.0-15.0] years, with a slight male predominance (58.0%). Of them, 6 (2.4%) children were tall, 30 (12.0% were short), and 214 (85.6%) were normal. A significantly higher proportion of short stature was observed in the T1DM group compared with the control group (6.1% vs. 1.7%; p = 0.016). Among T1DM participants, the proportion of short stature increased progressively with diabetes duration: 3.0% in new-onset disease, 14.9% in intermediate duration (2-5 years), and 25.0% in long-standing disease (>5 years) (p = 0.001). Age at onset of T1DM was also significantly associated with having short stature (p = 0.036). In multivariable analysis, intermediate duration (adjusted odds ratio [aOR] = 5.72, 95% CI (1.02-32.1); p = 0.047) and long-standing duration (aOR = 11.03, 95% CI: (1.09-111.45); p = 0.042) remained significant independent predictors of short stature. In contrast, glycemic control (HbA1c), vitamin D status, time in range, and treatment adherence were not significantly associated with short stature after adjustment. Conclusions: Children and adolescents with T1DM have significantly lower height percentiles and a higher prevalence of short stature compared to their controls. Diabetes duration is a strong, independent predictor of short stature in this population, with progressively higher risk as disease duration lengthens, regardless of glycemic control status. These findings underscore the necessity of systematic longitudinal growth monitoring, particularly in patients with disease duration exceeding five years, to enable early identification and intervention for those at highest risk of growth impairment. FAU - Alqahtani, Youssef A AU - Alqahtani YA AUID- ORCID: 0009-0001-8162-6288 AD - Department of Child Health, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia. FAU - A Shati, Ayed AU - A Shati A AUID- ORCID: 0000-0003-0444-5595 AD - Department of Child Health, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia. FAU - Alshaikh, Ayoub Ali AU - Alshaikh AA AD - Family and Community Medicine Department, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia. FAU - Fardan, Zeinh Hussein AU - Fardan ZH AD - Department of Child Health, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia. FAU - Alhuwail, Roaa Saad AU - Alhuwail RS AD - Asser Health Cluster, Ministry of Health, Abha 62523, Saudi Arabia. FAU - Almosleh, Dalia Salem A AU - Almosleh DSA AD - College of Medicine, King Khalid University, Abha 61421, Saudi Arabia. FAU - Alshehri, Abeer Mohammed AU - Alshehri AM AUID- ORCID: 0009-0002-5076-030X AD - College of Medicine, King Khalid University, Abha 61421, Saudi Arabia. FAU - Asiri, Maram Hadi A AU - Asiri MHA AD - College of Medicine, King Khalid University, Abha 61421, Saudi Arabia. FAU - Hammati, Shaden Essa AU - Hammati SE AUID- ORCID: 0009-0002-4921-2189 AD - College of Medicine, King Khalid University, Abha 61421, Saudi Arabia. FAU - Alsharif, Reema Abdullah S AU - Alsharif RAS AUID- ORCID: 0009-0009-6316-8461 AD - College of Medicine, King Khalid University, Abha 61421, Saudi Arabia. FAU - Ghazy, Ramy Mohamed AU - Ghazy RM AUID- ORCID: 0000-0001-7611-706X AD - Family and Community Medicine Department, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia. AD - Health and Medical Research Centre, King Khalid University, Abha 61421, Saudi Arabia. AD - Tropical Health Department, High Institute of Public Health, Alexandria University, Alexandria 21526, Egypt. LA - eng GR - y, grant number RGP2/461/46/King Khalid University/ PT - Journal Article DEP - 20260509 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13206814 OTO - NOTNLM OT - HbA1c OT - Saudi Arabia OT - children and adolescents OT - diabetes duration OT - growth impairment OT - short stature OT - type 1 diabetes mellitus OT - vitamin D COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 06:34 MHDA- 2026/05/27 06:35 PMCR- 2026/05/09 CRDT- 2026/05/27 01:10 PHST- 2026/04/13 00:00 [received] PHST- 2026/05/05 00:00 [revised] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/05/27 06:35 [medline] PHST- 2026/05/27 06:34 [pubmed] PHST- 2026/05/27 01:10 [entrez] PHST- 2026/05/09 00:00 [pmc-release] AID - jcm15103629 [pii] AID - jcm-15-03629 [pii] AID - 10.3390/jcm15103629 [doi] PST - epublish SO - J Clin Med. 2026 May 9;15(10):3629. doi: 10.3390/jcm15103629. PMID- 42194143 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260527 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 5 DP - 2026 Apr 29 TI - Development and Validation of Non-Invasive Machine-Learning Screening Models for Pediatric Malnutrition in Hospitalized Children: A Single-Center Study. LID - 10.3390/children13050617 [doi] LID - 617 AB - Background/Objectives: Child malnutrition is a global health challenge linked to poor growth, impaired development, weakened immunity, and adverse outcomes. Early risk detection is essential, but current screening tools differ in accuracy and feasibility. This study aimed to develop and validate new bedside pediatric malnutrition screening models based on machine learning and evolutionary computation methods that can capture complex patterns in non-invasive clinical indicators while remaining practical for routine ward use. Methods: We conducted a cross-sectional study including 180 hospitalized children (1 month-18 years) recruited consecutively from six pediatric wards. The required sample size (minimum 138 participants) was calculated a priori using national prevalence estimates of pediatric undernutrition (4-9.5%) to ensure adequate precision at a 95% confidence level. Data collection included a questionnaire, anthropometry, subjective malnutrition risk assessment, and the Subjective Global Nutritional Assessment (SGNA) tool. Screening models were developed using decision trees, random forests, XGBoost, lasso regression, artificial neural networks, ANFIS, and genetic programming. Their performance was evaluated against the SGNA tool and physician-based subjective malnutrition risk assessment using sensitivity, specificity, AUC, and Cohen's kappa. Results: Machine learning and intelligent evolutionary models (GP, ANN, and ANFIS) showed the best performance in this sample, with substantial to high agreement (kappa = 0.81-1.00) and high diagnostic accuracy (AUC = 0.92-1.00) with the subjective malnutrition risk assessment. The GP model demonstrated the highest apparent accuracy in this dataset, but also higher complexity, whereas simpler models such as decision trees showed lower accuracy but greater interpretability and feasibility for routine clinical use. However, validation was performed on a relatively small independent sample, and no external validation was conducted, which may limit the generalizability of the findings. Conclusions: While complex models may serve as digital assessment instruments, simpler models are rapid and more suitable for bedside screening. All developed models are non-invasive and cost-effective and show potential for supportive approaches for early detection of malnutrition risk at hospital admission. However, given the limited validation sample and the absence of external validation, these findings should be interpreted with caution, and further large-scale, multicenter studies are required to confirm generalizability and clinical applicability. FAU - Klanjsek, Petra AU - Klanjsek P AD - Faculty of Health Sciences, University of Maribor, Zitna ulica 15, 2000 Maribor, Slovenia. FAU - Brzan, Petra Povalej AU - Brzan PP AUID- ORCID: 0000-0001-7872-586X AD - Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia. AD - Faculty of Electrical Engineering and Computer Science, University of Maribor, Koroska cesta 46, 2000 Maribor, Slovenia. FAU - Varda, Natasa Marcun AU - Varda NM AUID- ORCID: 0000-0003-0634-3576 AD - Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia. AD - University Division of Paediatrics, University Medical Centre Maribor, Ljubljanska ulica 5, 2000 Maribor, Slovenia. FAU - Mocnik, Mirjam AU - Mocnik M AD - University Division of Paediatrics, University Medical Centre Maribor, Ljubljanska ulica 5, 2000 Maribor, Slovenia. FAU - Golob Jancic, Sonja AU - Golob Jancic S AUID- ORCID: 0000-0002-6201-7321 AD - University Division of Paediatrics, University Medical Centre Maribor, Ljubljanska ulica 5, 2000 Maribor, Slovenia. FAU - Kovacic, Miha AU - Kovacic M AD - Faculty of Mechanical Engineering, University of Ljubljana, Askerceva cesta 6, 1000 Ljubljana, Slovenia. AD - College of Industrial Engineering, Mariborska cesta 2, 3000 Celje, Slovenia. AD - Store Steel d.o.o., Zelezarska cesta 3, 3220 Store, Slovenia. FAU - Pajnkihar, Majda AU - Pajnkihar M AD - Faculty of Health Sciences, University of Maribor, Zitna ulica 15, 2000 Maribor, Slovenia. LA - eng PT - Journal Article DEP - 20260429 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13204657 OTO - NOTNLM OT - SGNA OT - evolutionary computation OT - genetic programming OT - machine learning OT - malnutrition risk screening OT - nutritional assessment tool OT - nutritional risk screening/assessment OT - nutritional screening tools OT - pediatric malnutrition OT - pediatric undernutrition COIS- Author Miha Kovacic was employed by the company Store Steel d.o.o. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/27 06:33 MHDA- 2026/05/27 06:34 PMCR- 2026/04/29 CRDT- 2026/05/27 01:09 PHST- 2026/03/27 00:00 [received] PHST- 2026/04/24 00:00 [revised] PHST- 2026/04/25 00:00 [accepted] PHST- 2026/05/27 06:34 [medline] PHST- 2026/05/27 06:33 [pubmed] PHST- 2026/05/27 01:09 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - children13050617 [pii] AID - children-13-00617 [pii] AID - 10.3390/children13050617 [doi] PST - epublish SO - Children (Basel). 2026 Apr 29;13(5):617. doi: 10.3390/children13050617. PMID- 42194009 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2218-273X (Electronic) IS - 2218-273X (Linking) VI - 16 IP - 5 DP - 2026 Apr 28 TI - Inverse Correlation Between Nesfatin-1 and Ghrelin O-Acyltransferase (GOAT) in Adolescents with Epilepsy: A Cross-Sectional Study. LID - 10.3390/biom16050658 [doi] LID - 658 AB - Nesfatin-1 and ghrelin O-acyltransferase (GOAT) have established roles in metabolic regulation and neuronal excitability, yet their relationship in epilepsy remains conflicted. This cross-sectional study compared 22 adolescent epilepsy patients (13.1 +/- 2.0 years; 11 women/11 men) with 20 age-matched healthy controls (HCs) (12.3 +/- 2.2 years; 8 women/12 men). Serum and salivary nesfatin-1 and GOAT levels were measured by enzyme-linked immunosorbent assay; Spearman's rank correlation assessed inter-neuropeptide relationships. Serum nesfatin-1 was markedly elevated in patients with epilepsy compared to HCs (44.04 (interquartile range 38.19-76.72) vs. 8.65 (interquartile range 7.82-9.01) ng/mL, p < 0.001; ~5-fold). Serum GOAT was similarly elevated (4.90 (interquartile range 4.17-6.66) vs. 1.41 (interquartile range 1.21-1.79) ng/mL, p < 0.001; 3.5-fold). A significant inverse correlation between serum nesfatin-1 and GOAT levels was identified in patients with epilepsy (rho = -0.68, 95% CI [-0.86, -0.36], p < 0.001) but not in HCs (p = 0.53) and remained independent of age, sex, body mass index and epilepsy type. This inverse correlation was significant in women (rho = -0.68, p = 0.021) with a similar trend in men (rho = -0.53, p = 0.096). Salivary nesfatin-1 mirrored serum patterns (2.3-fold increase; p < 0.001), while salivary GOAT showed a 9-fold reduction (p < 0.001). This study provides the first evidence of an inverse nesfatin-1/GOAT correlation in adolescent epilepsy, suggesting disease-specific neuroendocrine dysregulation. These exploratory findings support the potential of these neuropeptides as candidate biomarkers warranting further validation and offer new insights into the metabolic-excitability axis in epilepsy. FAU - Sojka, Anna AU - Sojka A AD - Department of Prosthodontics and Gerostomatology, Poznan University of Medical Sciences, 60-812 Poznan, Poland. FAU - Yetkin, Ozgun AU - Yetkin O AUID- ORCID: 0000-0003-4110-8002 AD - Department of Developmental Neurology, Poznan University of Medical Sciences, 60-355 Poznan, Poland. AD - Doctoral School, Poznan University of Medical Sciences, 60-812 Poznan, Poland. FAU - Bartosik, Yasmin AU - Bartosik Y AD - Department of Prosthodontics and Gerostomatology, Poznan University of Medical Sciences, 60-812 Poznan, Poland. FAU - Steinborn, Barbara AU - Steinborn B AD - Department of Developmental Neurology, Poznan University of Medical Sciences, 60-355 Poznan, Poland. FAU - Dorocka-Bobkowska, Barbara AU - Dorocka-Bobkowska B AUID- ORCID: 0000-0003-3659-7761 AD - Department of Prosthodontics and Gerostomatology, Poznan University of Medical Sciences, 60-812 Poznan, Poland. FAU - Zarowski, Marcin AU - Zarowski M AUID- ORCID: 0000-0002-9800-9446 AD - Department of Developmental Neurology, Poznan University of Medical Sciences, 60-355 Poznan, Poland. LA - eng PT - Journal Article DEP - 20260428 PL - Switzerland TA - Biomolecules JT - Biomolecules JID - 101596414 RN - 0 (Nucleobindins) RN - 0 (NUCB2 protein, human) RN - EC 2.3.- (Acyltransferases) RN - EC 2.3.- (MBOAT4 protein, human) RN - 0 (Nerve Tissue Proteins) RN - 0 (DNA-Binding Proteins) RN - 0 (Calcium-Binding Proteins) SB - IM MH - Humans MH - Female MH - *Nucleobindins/blood/metabolism MH - Male MH - Adolescent MH - Cross-Sectional Studies MH - *Epilepsy/blood/metabolism MH - Child MH - *Acyltransferases/blood/metabolism MH - *Nerve Tissue Proteins/blood MH - Case-Control Studies MH - *DNA-Binding Proteins/blood MH - Saliva/metabolism MH - Calcium-Binding Proteins/blood PMC - PMC13204653 OTO - NOTNLM OT - adolescents OT - biomarkers OT - epilepsy OT - ghrelin OT - ghrelin o-acyltransferase OT - nesfatin-1 OT - neuropeptides COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 06:34 MHDA- 2026/05/27 06:35 PMCR- 2026/04/28 CRDT- 2026/05/27 01:08 PHST- 2026/03/05 00:00 [received] PHST- 2026/04/18 00:00 [revised] PHST- 2026/04/27 00:00 [accepted] PHST- 2026/05/27 06:35 [medline] PHST- 2026/05/27 06:34 [pubmed] PHST- 2026/05/27 01:08 [entrez] PHST- 2026/04/28 00:00 [pmc-release] AID - biom16050658 [pii] AID - biomolecules-16-00658 [pii] AID - 10.3390/biom16050658 [doi] PST - epublish SO - Biomolecules. 2026 Apr 28;16(5):658. doi: 10.3390/biom16050658. PMID- 42193668 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260527 LR - 20260813 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 5 DP - 2026 May 15 TI - Determinants of Physical Activity Engagement Among Male Adolescents in Riyadh, Saudi Arabia: A Comparative Study of Athletes and Non-Athletes. LID - 10.3390/bs16050789 [doi] LID - 789 AB - Background: Physical inactivity among Saudi Arabian adolescents is a critical public health concern due to its contribution to the rising prevalence of overweight, obesity, and non-communicable diseases. Despite this, the motivational profiles and perceived barriers that differentiate athletic from non-athletic adolescents remain understudied in the Saudi literature, particularly within the school Physical Education (PE) context. Grounded in Self-Determination Theory (SDT), the present study examined the factors preventing and motivating Saudi adolescents to engage in physical activity (PA) and discusses findings in terms of their implications for PE teachers and school-based intervention. Method: A cross-sectional study was conducted with 124 male high school students in Riyadh (mean age: 16.79 +/- 0.66 years). Participants were categorized as either athletes (n = 70) or non-athletes (n = 54) based on pre-defined engagement criteria: athletes were required to report vigorous-intensity sport participation on three or more days per week for a minimum of 60 min per session. Anthropometric measurements, lifestyle behaviors (diet, screen time, sleep), motivations, and barriers were assessed using the validated Arab Teens Lifestyle Study (ATLS) questionnaire. Independent samples t-tests and chi-square tests were used to compare between-group differences; effect sizes are reported. Result: Non-athletes had a significantly higher mean BMI (29.40 +/- 6.77 kg/m(2)) and waist circumference (98.65 +/- 21.63 cm) compared to athletes (BMI: 22.19 +/- 4.44 kg/m(2); waist: 78.84 +/- 9.51 cm; both p < 0.001). No significant differences were observed in screen time, sleep duration, or dietary habits. The primary motivations for PA among athletes were health benefits (27.1%), recreation (25.7%), and competition (20.0%), reflecting an autonomous motivational profile consistent with SDT. Among non-athletes, the predominant barriers were the lack of suitable facilities (25.9%) and the absence of an exercise partner (22.2%); reflecting unmet SDT needs for competence and relatedness respectively, while only 9.3% cited having a lack of time. Conclusions: Non-athletic participants face a significant health disadvantage characterized by higher rates of overweight and central obesity. In contrast to global trends, where academic commitments dominate barriers to PA, the principal barriers in this population are environmental and social, reflecting unmet psychological needs that PE teachers are uniquely positioned to address. Rather than focusing solely on infrastructure, PE promoters should implement need-supportive teaching practices, including competence-building tasks and cooperative peer structures, to foster the intrinsic motivational profile observed in the athletes and promote long-term PA adherence among non-athletic students, in alignment with the health objectives of Saudi Vision 2030. FAU - Alaqil, Abdulrahman I AU - Alaqil AI AUID- ORCID: 0000-0003-0458-2354 AD - Department of Physical Education, College of Education, King Faisal University, Al-Ahsa 31982, Saudi Arabia. FAU - Bin Radhyan, Fahad AU - Bin Radhyan F AUID- ORCID: 0000-0003-3037-0435 AD - Department of Physical Education, College of General Studies, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260515 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13203752 OTO - NOTNLM OT - Saudi Arabia OT - Self-Determination Theory OT - adolescents OT - barriers OT - motivation OT - obesity OT - physical activity COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 06:37 MHDA- 2026/05/27 06:38 PMCR- 2026/05/15 CRDT- 2026/05/27 01:07 PHST- 2026/03/31 00:00 [received] PHST- 2026/05/06 00:00 [revised] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/05/27 06:38 [medline] PHST- 2026/05/27 06:37 [pubmed] PHST- 2026/05/27 01:07 [entrez] PHST- 2026/05/15 00:00 [pmc-release] AID - bs16050789 [pii] AID - behavsci-16-00789 [pii] AID - 10.3390/bs16050789 [doi] PST - epublish SO - Behav Sci (Basel). 2026 May 15;16(5):789. doi: 10.3390/bs16050789. PMID- 42193600 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260527 LR - 20260813 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 5 DP - 2026 May 7 TI - Adolescent Sports Learning Interest and Subjective Well-Being: The Chain Mediating Role of Social Anxiety and Sleep Quality. LID - 10.3390/bs16050721 [doi] LID - 721 AB - OBJECTIVE: While the benefits of physical activity are well-documented, the internal mechanisms linking sports interest to adolescent Subjective Well-being (SWB) remain under-explored. This study addresses this gap by investigating the association between Sports Learning Interest and SWB and examining the serial mediating roles of Social Anxiety and Sleep Quality. METHODS: Using a stratified random sampling method, 1764 primary and secondary students were surveyed with validated instruments, including the PSQI and the Index of Well-Being. Data were analyzed using Hayes' PROCESS macro (Model 6) to test the hypothesized chain mediation effects. RESULTS: Sports Learning Interest significantly and positively predicted SWB. The model identified three significant indirect pathways: independent mediation by Social Anxiety, independent mediation by Sleep Quality, and a serial chain from Social Anxiety --> Sleep Quality (total indirect effect = 0.18, 95% CI [0.15, 0.21]). Notably, Sleep Quality emerged as the core mediator, accounting for 29.9% of the total effect. CONCLUSIONS: Enhancing sports interest is positively associated with SWB through a "psychological-physiological" dual channel-specifically by its association with lower social anxiety and subsequently better sleep. These findings provide empirical evidence for designing school-based interventions that integrate physical education with mental health promotion. FAU - Qi, Hanlin AU - Qi H AD - Faculty of Psychology, Shinawatra University, Bang Toey, Sam Khok, Pathum Thani 12160, Thailand. FAU - Bhutasang, Natchana AU - Bhutasang N AD - Faculty of Psychology, Shinawatra University, Bang Toey, Sam Khok, Pathum Thani 12160, Thailand. FAU - Liu, Shixiang AU - Liu S AD - Department of Psychology, Teachers College of Beijing Union University, Beijing 100011, China. FAU - Zhang, Wen AU - Zhang W AD - School of Psychology, Qufu Normal University, No. 57 Jingxuan West Road, Qufu 273165, China. LA - eng GR - JK202506/Education Science Research Project of Beijing Union University/ PT - Journal Article DEP - 20260507 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13203127 OTO - NOTNLM OT - adolescent OT - chain mediation OT - sleep quality OT - social anxiety OT - sports learning interest OT - subjective well-being COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 06:34 MHDA- 2026/05/27 06:35 PMCR- 2026/05/07 CRDT- 2026/05/27 01:07 PHST- 2026/03/12 00:00 [received] PHST- 2026/04/21 00:00 [revised] PHST- 2026/04/28 00:00 [accepted] PHST- 2026/05/27 06:35 [medline] PHST- 2026/05/27 06:34 [pubmed] PHST- 2026/05/27 01:07 [entrez] PHST- 2026/05/07 00:00 [pmc-release] AID - bs16050721 [pii] AID - behavsci-16-00721 [pii] AID - 10.3390/bs16050721 [doi] PST - epublish SO - Behav Sci (Basel). 2026 May 7;16(5):721. doi: 10.3390/bs16050721. PMID- 42193371 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260527 LR - 20260813 IS - 2227-9059 (Print) IS - 2227-9059 (Electronic) IS - 2227-9059 (Linking) VI - 14 IP - 5 DP - 2026 May 4 TI - Environmental Radon Exposure and Inflammatory Responses in Children and Adolescents: Evidence from a High-Radon Region in Kazakhstan. LID - 10.3390/biomedicines14051045 [doi] LID - 1045 AB - Background/Objectives: Radon is a naturally occurring radioactive gas and the leading source of natural radiation exposure worldwide; however, its systemic biological effects in children remain poorly understood. This study examined the association between cumulative indoor radon exposure and inflammatory biomarkers among children residing in rural communities of the Aqmola region in Kazakhstan. Methods: The study included 87 children and adolescents (42 exposed and 45 controls). Radon exposure was measured in residential and school environments, and a composite Radon Exposure Index (REI) was constructed to estimate cumulative exposure over time. Serum concentrations of inflammatory biomarkers, including C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and interleukin-8 (IL-8), were measured using validated immunoassay methods. Multivariable linear regression models adjusted for age, sex, body mass index, pubertal development stage, and heating type were used to evaluate associations between REI and biomarker levels. Results: Children and adolescents living in the radon-exposed community had significantly higher REI values than controls (7.75 +/- 0.85 vs.4.83 +/- 0.41, respectively). Among the biomarkers examined, CRP, TNF-alpha, IL-1beta, IL-8 and IL-6 were not significantly associated with radon exposure. Conclusions: These findings do not support the use of the evaluated inflammatory biomarkers as indicators of early biological effects of environmental radon exposure in this population. However, the clear exposure contrast observed between study settings underscores the ongoing public health relevance of radon as an environmental hazard. Continued efforts to monitor and mitigate radon exposure in high-risk regions remain essential, particularly in environments where children spend substantial amounts of time. FAU - Lesbek, Anel AU - Lesbek A AUID- ORCID: 0009-0005-1231-2946 AD - Institute of Radiobiology and Radiation Protection NJSC, Astana Medical University, Astana 010000, Kazakhstan. FAU - Omori, Yasutaka AU - Omori Y AUID- ORCID: 0000-0003-3629-8761 AD - Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki 036-8564, Japan. FAU - Bakhtin, Meirat AU - Bakhtin M AD - Institute of Radiobiology and Radiation Protection NJSC, Astana Medical University, Astana 010000, Kazakhstan. FAU - Miura, Tomisato AU - Miura T AUID- ORCID: 0000-0003-3104-2134 AD - Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki 036-8564, Japan. FAU - Tokonami, Shinji AU - Tokonami S AUID- ORCID: 0000-0002-6617-7402 AD - Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki 036-8564, Japan. FAU - Kazymbet, Polat AU - Kazymbet P AD - Institute of Radiobiology and Radiation Protection NJSC, Astana Medical University, Astana 010000, Kazakhstan. FAU - Ibrayeva, Danara AU - Ibrayeva D AUID- ORCID: 0000-0002-1640-1728 AD - Institute of Radiobiology and Radiation Protection NJSC, Astana Medical University, Astana 010000, Kazakhstan. FAU - Altaeva, Nursulu AU - Altaeva N AD - Department of Medical Genetics and Molecular Biology NJSC, Astana Medical University, Astana 010000, Kazakhstan. FAU - Kazhiyakhmetova, Baglan AU - Kazhiyakhmetova B AUID- ORCID: 0009-0009-0357-5989 AD - Institute of Radiobiology and Radiation Protection NJSC, Astana Medical University, Astana 010000, Kazakhstan. FAU - Saifulina, Elena AU - Saifulina E AUID- ORCID: 0000-0002-1791-0137 AD - Institute of Radiobiology and Radiation Protection NJSC, Astana Medical University, Astana 010000, Kazakhstan. FAU - Shokabayeva, Aigerim AU - Shokabayeva A AD - Institute of Radiobiology and Radiation Protection NJSC, Astana Medical University, Astana 010000, Kazakhstan. FAU - Mussayeva, Elvira AU - Mussayeva E AUID- ORCID: 0000-0001-8012-2590 AD - Institute of Radiobiology and Radiation Protection NJSC, Astana Medical University, Astana 010000, Kazakhstan. FAU - Mulkat, Yelshenbek AU - Mulkat Y AD - Institute of Radiobiology and Radiation Protection NJSC, Astana Medical University, Astana 010000, Kazakhstan. FAU - Kashkinbayev, Yerlan AU - Kashkinbayev Y AUID- ORCID: 0000-0002-6095-459X AD - Institute of Radiobiology and Radiation Protection NJSC, Astana Medical University, Astana 010000, Kazakhstan. LA - eng GR - grant number IRN AP22786933/Committee of Science of the Ministry of Science and Higher Education of the Republic of Kazakhstan/ PT - Journal Article DEP - 20260504 PL - Switzerland TA - Biomedicines JT - Biomedicines JID - 101691304 PMC - PMC13203900 OTO - NOTNLM OT - Kazakhstan OT - Radon Exposure Index OT - adolescents OT - environmental health OT - environmental radiation OT - inflammatory biomarkers OT - interleukin-8 OT - radon exposure OT - rural populations OT - serum biomarkers COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 06:39 MHDA- 2026/05/27 06:40 PMCR- 2026/05/04 CRDT- 2026/05/27 01:06 PHST- 2026/04/11 00:00 [received] PHST- 2026/04/29 00:00 [revised] PHST- 2026/05/01 00:00 [accepted] PHST- 2026/05/27 06:40 [medline] PHST- 2026/05/27 06:39 [pubmed] PHST- 2026/05/27 01:06 [entrez] PHST- 2026/05/04 00:00 [pmc-release] AID - biomedicines14051045 [pii] AID - biomedicines-14-01045 [pii] AID - 10.3390/biomedicines14051045 [doi] PST - epublish SO - Biomedicines. 2026 May 4;14(5):1045. doi: 10.3390/biomedicines14051045. PMID- 42192480 OWN - NLM STAT- MEDLINE DCOM- 20260721 LR - 20260813 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 May 26 TI - Digital addiction comorbidity patterns and their differential links to internalizing symptoms, suicidal behaviors and non-suicidal self-injury in vocational high school students. LID - 10.1186/s40359-026-04873-z [doi] LID - 1077 AB - BACKGROUND: Digital addiction is a growing public health concern among adolescents, yet evidence on co-occurring addiction patterns and their differential associations with mental health outcomes remains limited, particularly in vocational students. METHODS: A cross-sectional survey of 15,311 vocational high school students was conducted in Zigong, China. Smartphone, gaming, and social media addiction were assessed using validated scales. Participants were classified into no addiction, single addiction, and multiple addictions groups. Outcomes included internalizing symptoms (clinically significant depression or anxiety), suicidal behaviors (ideation, planning, or attempts), and non-suicidal self-injury (NSSI). Hierarchical regression models with progressive adjustment were supplemented by sensitivity analyses using continuous scores and operating characteristic (ROC)-derived alternative cut-offs. RESULTS: A total of 20.9% of participants met the criteria for one form of digital addiction, with smartphone-only addiction being the most prevalent pattern (19.4%). A graded association was observed, with the prevalence of all adverse outcomes increasing progressively with the number of addictions (all p < 0.001). In fully adjusted models, single addiction was associated with internalizing symptoms (OR = 1.77, 95% CI: 1.54-2.04), suicidal behaviors (OR = 1.38, 95% CI: 1.24-1.52), and NSSI (OR = 1.42, 95% CI: 1.24-1.63). Multiple addictions were associated with internalizing symptoms (OR = 5.58, 95% CI: 3.71-8.41) and suicidal behaviors (OR = 2.56, 95% CI: 1.74-3.77), but the association with NSSI was attenuated (OR = 1.17, 95% CI: 0.81-1.70, p = 0.404). When the three continuous addiction scores were mutually adjusted, smartphone addiction severity remained independently associated only with internalizing symptoms (OR = 1.05, 95% CI: 1.04-1.06), whereas gaming and social media addiction severities were independently associated with both suicidal behaviors and NSSI. Triple addiction was associated with the highest risk of suicidal behaviors (OR = 3.42, 95% CI: 1.62-7.21). Sensitivity analyses using data-driven ROC-optimal cut-offs preserved the core graded pattern. CONCLUSION: Co-occurring digital addictions are common among vocational students and exhibit graded associations with adverse mental health outcomes. Smartphone addiction appears primarily linked to internalizing distress, while gaming and social media addictions are independently associated with self-harm, underscoring the importance of assessing specific digital activities rather than total screen time. CI - (c) 2026. The Author(s). FAU - Wen, Liping AU - Wen L AD - Department of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, 666 Gongshu Road, Zigong, Sichuan Province, 643020, China. FAU - Xu, Lu AU - Xu L AD - Department of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, 666 Gongshu Road, Zigong, Sichuan Province, 643020, China. FAU - Bai, Li AU - Bai L AD - Department of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, 666 Gongshu Road, Zigong, Sichuan Province, 643020, China. FAU - Zhu, Lingyan AU - Zhu L AD - Department of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, 666 Gongshu Road, Zigong, Sichuan Province, 643020, China. FAU - Liao, Liangxue AU - Liao L AD - Department of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, 666 Gongshu Road, Zigong, Sichuan Province, 643020, China. FAU - He, Ruini AU - He R AD - Department of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, 666 Gongshu Road, Zigong, Sichuan Province, 643020, China. FAU - Liu, Kezhi AU - Liu K AD - Department of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, 666 Gongshu Road, Zigong, Sichuan Province, 643020, China. liukezhi@swmu.edu.cn. AD - Department of Psychiatry, Affliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China. liukezhi@swmu.edu.cn. FAU - Wang, Yilin AU - Wang Y AD - Department of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, 666 Gongshu Road, Zigong, Sichuan Province, 643020, China. wangyilinzg0321@163.com. LA - eng GR - 2025-NKY-01-01/the Zigong Key Science and Technology Plan (Collaborative Innovation Project of Zigong Institute of Brain Sciences)/ PT - Journal Article DEP - 20260526 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Adolescent MH - *Students/psychology/statistics & numerical data MH - China/epidemiology MH - Comorbidity MH - Female MH - *Self-Injurious Behavior/epidemiology/psychology MH - *Internet Addiction Disorder/epidemiology/psychology MH - Cross-Sectional Studies MH - *Behavior, Addictive/epidemiology/psychology MH - Male MH - Smartphone MH - Digital Media MH - Suicidal Ideation MH - *Social Media MH - *Depression/epidemiology MH - *Anxiety/epidemiology PMC - PMC13386748 OTO - NOTNLM OT - Digital addiction OT - Gaming disorder OT - Sleep disturbance OT - Smartphone addiction OT - Social media addiction OT - Suicidal behaviors OT - Vocational high school students COIS- Declarations. Ethics approval and consent to participate: This investigation strictly followed the Declaration of Helsinki, and received ethical approval from received ethical approval from the Zigong Mental Health Center in China (Approval No. 2020-8-01). Written informed consent was obtained from all participants aged 18 or above, while in the case of minors, parental or legal guardian consent was obtained, alongside student assent. All data were anonymized and stored securely. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/27 06:34 MHDA- 2026/07/21 06:34 PMCR- 2026/05/26 CRDT- 2026/05/27 00:35 PHST- 2026/03/12 00:00 [received] PHST- 2026/05/22 00:00 [accepted] PHST- 2026/07/21 06:34 [medline] PHST- 2026/05/27 06:34 [pubmed] PHST- 2026/05/27 00:35 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - 10.1186/s40359-026-04873-z [pii] AID - 4873 [pii] AID - 10.1186/s40359-026-04873-z [doi] PST - epublish SO - BMC Psychol. 2026 May 26;14(1):1077. doi: 10.1186/s40359-026-04873-z. PMID- 42190145 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260926 IS - 1526-632X (Electronic) IS - 0028-3878 (Print) IS - 0028-3878 (Linking) VI - 106 IP - 12 DP - 2026 Jun 23 TI - A Validated Prognostic Score for Time to Loss of Ambulation in Patients With Duchenne Muscular Dystrophy. PG - e214705 LID - 10.1212/WNL.0000000000214705 [doi] LID - e214705 AB - BACKGROUND AND OBJECTIVES: Development of a prognostic score for time to loss of ambulation (LoA) may help guide treatment of patients with Duchenne muscular dystrophy (DMD). Information from clinical data sources was used to create a prognostic score for LoA for use in practice. METHODS: Data used included 4 natural history databases and 3 clinical trial placebo arms. Inclusion criteria were as follows: (1) 6-minute walk distance >/=75 m; (2) a subsequent visit with an outcome assessment that identified LoA; (3) current corticosteroid use; and (4) available data on prognostic factors. Classification and regression tree models for time to LoA were used to classify patients into 5 risk groups (group 5 = highest risk), prioritizing the easily obtained rise from floor (RFF) and 10-m walk/run (10MWR) times as predictors. The prognostic score was validated in the Cooperative International Neuromuscular Research Group data. RESULTS: Data from 608 boys were analyzed (mean age 9.1 years). Kaplan-Meier curves for time to LoA for each risk group were well separated, describing meaningful differences in time to LoA. Median time to LoA for risk group 1 was not reached during a median of 2.0 years of follow-up. Median times to LoA for risk groups 2-5 were 4.4 (95% CI 4.0-inf), 3.0 (2.1-4.1), 2.0 (1.6-2.1), and 0.9 (0.8-1.6) years, respectively. These risk groups showed concordant times to LoA among 226 patients in the validation data and provided finer separation of patients across different levels of LoA risk than thresholds based on individual functional tests. DISCUSSION: Patients with DMD were classified into 5 risk groups for LoA using a simple, easy-to-use prognostic score based on RFF and 10MWR thresholds. The prognostic score replicated well in validation data and performed better than previously proposed classifications used in practice. Incorporating the prognostic score for time to LoA into a clinical visit may allow clinicians to counsel patients on trial eligibility, need for mobility devices, home adjustments, financial accommodations, and psychosocial needs. The prognostic score may also be used in trials to inform inclusion criteria and stratification. Study limitations included limited data for prediction of LoA risk beyond 4 years. FAU - McDonald, Craig M AU - McDonald CM AUID- ORCID: 0000-0002-8779-3220 AD - Department of Physical Medicine and Rehabilitation and Department of Pediatrics, University of California Davis Health, The Cooperative International Neuromuscular Research Group, Sacramento, CA. FAU - Signorovitch, James AU - Signorovitch J AD - Analysis Group, Inc., Boston, MA. AD - Collaborative Trajectory Analysis Project, Cambridge, MA. FAU - Goemans, Nathalie Marie AU - Goemans NM AUID- ORCID: 0000-0002-5157-7155 AD - Child Neurology, University Hospitals Leuven, Leuven, Belgium. FAU - Mercuri, Eugenio AU - Mercuri E AUID- ORCID: 0000-0002-9851-5365 AD - Child Neurology Unit e Centro Nemo, IRCCS Fondazione Policlinico Gemelli, Universita Cattolica del Sacro Cuore, Rome, Italy. FAU - Gordish-Dressman, Heather AU - Gordish-Dressman H AUID- ORCID: 0000-0002-2330-5427 AD - Department of Physical Medicine and Rehabilitation and Department of Pediatrics, University of California Davis Health, The Cooperative International Neuromuscular Research Group, Sacramento, CA. AD - Children's National Hospital, Washington, DC. FAU - Vandenborne, Krista AU - Vandenborne K AD - University of Florida, Gainseville, FL. FAU - Sajeev, Gautam AU - Sajeev G AUID- ORCID: 0000-0002-1827-8938 AD - Analysis Group, Inc., Boston, MA. FAU - Ward, Susan J AU - Ward SJ AD - Collaborative Trajectory Analysis Project, Cambridge, MA. FAU - Fillbrunn, Mirko AU - Fillbrunn M AD - Analysis Group, Inc., Boston, MA. FAU - Frean, Molly AU - Frean M AUID- ORCID: 0000-0002-5770-4266 AD - Analysis Group, Inc., Boston, MA. FAU - Servais, Laurent AU - Servais L AUID- ORCID: 0000-0001-9270-4061 AD - MDUK Oxford Neuromuscular Centre, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Center, United Kingdom. AD - Neuromuscular Center of Liege, Division of Paediatrics, CHU and University of Liege, Belgium. FAU - Niks, Erik H AU - Niks EH AUID- ORCID: 0000-0001-5892-5143 AD - Department of Neurology, Leiden University Medical Center, the Netherlands. FAU - Straub, Volker AU - Straub V AUID- ORCID: 0000-0001-9046-3540 AD - John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom. FAU - De Groot, Imelda J M AU - De Groot IJM AUID- ORCID: 0000-0003-1634-1427 AD - Department of Rehabilitation, Donders Centre of Neuroscience, Radboud University Nijmegen Medical Center, the Netherlands; and. FAU - Muntoni, Francesco AU - Muntoni F AUID- ORCID: 0000-0002-9102-5232 AD - UCL Great Ormond Street Institute of Child Health and Biomedical Research Centre, London, United Kingdom. CN - iMDEX, for the PRO-DMD-01 Study, ImagingDMD, CINRG DNHS, and Universitaire Ziekenhuizen Leuven Group LA - eng PT - Journal Article DEP - 20260526 PL - United States TA - Neurology JT - Neurology JID - 0401060 SB - IM CIN - Neurology. 106:e214882. PMID: 42190149 MH - Humans MH - *Muscular Dystrophy, Duchenne/diagnosis/physiopathology MH - Male MH - Prognosis MH - *Walking/physiology MH - Child MH - Adolescent MH - Time Factors MH - Kaplan-Meier Estimate PMC - PMC13312938 EDAT- 2026/05/26 23:33 MHDA- 2026/05/27 00:30 PMCR- 2026/05/26 CRDT- 2026/05/26 16:02 PHST- 2026/05/27 00:30 [medline] PHST- 2026/05/26 23:33 [pubmed] PHST- 2026/05/26 16:02 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - WNL-2025-204418 [pii] AID - 10.1212/WNL.0000000000214705 [doi] PST - ppublish SO - Neurology. 2026 Jun 23;106(12):e214705. doi: 10.1212/WNL.0000000000214705. Epub 2026 May 26. PMID- 42188554 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260526 LR - 20260813 IS - 2075-4663 (Electronic) IS - 2075-4663 (Linking) VI - 14 IP - 5 DP - 2026 Apr 29 TI - Construction and Validation of a Specific Balance Test for Rhythmic Gymnasts: A Pilot Study. LID - 10.3390/sports14050178 [doi] LID - 178 AB - BACKGROUND: Balance is a key ability in rhythmic gymnastics, affecting not only technical performance but also the aesthetic and expressive quality of routines. Standard tests often do not reflect the real demands of the sport, where gymnasts must simultaneously maintain stability, manipulate apparatus, and follow the musical rhythm. Therefore, there is a need for a specific test that combines motor and cognitive challenges to provide a precise and reliable assessment of athletes' functional abilities. METHODS: The study involved 12 girls with an average age of 9 years. Participants underwent anthropometric measurements and were tested using standard motor tests as well as a specific balance test for rhythmic gymnasts (BTRG). Test reliability was assessed using a test-retest procedure, and construct validity was evaluated through factor analysis in comparison with existing balance tests. RESULTS: The BTRG demonstrated high reliability (ICC = 0.96; CV = 6.4%; SEM = 0.18) and the ability to distinguish gymnasts from different programs. Factor analysis confirmed that the BTRG effectively measures specific balance in accordance with theoretical expectations. CONCLUSIONS: The new test provides a potentially valid and reliable tool for assessing specific balance in rhythmic gymnasts and maybe useful in the training process, athlete evaluation, and talent development; however, these finding should be interpreted with caution as they are preliminary and derived from pilot study. FAU - Stojkovic, Rebeka AU - Stojkovic R AD - Faculty of Kinesiology, University of Josip Juraj Strossmayer in Osijek, Drinska 16a, 31000 Osijek, Croatia. FAU - Peric, Ivan AU - Peric I AUID- ORCID: 0000-0002-4897-0925 AD - Faculty of Kinesiology, University of Josip Juraj Strossmayer in Osijek, Drinska 16a, 31000 Osijek, Croatia. FAU - Tomac, Zvonimir AU - Tomac Z AD - Faculty of Kinesiology, University of Josip Juraj Strossmayer in Osijek, Drinska 16a, 31000 Osijek, Croatia. FAU - Ajman, Hrvoje AU - Ajman H AUID- ORCID: 0000-0003-3663-4008 AD - Faculty of Kinesiology, University of Josip Juraj Strossmayer in Osijek, Drinska 16a, 31000 Osijek, Croatia. FAU - Spoljaric, Zoran AU - Spoljaric Z AD - Faculty of Kinesiology, University of Josip Juraj Strossmayer in Osijek, Drinska 16a, 31000 Osijek, Croatia. LA - eng PT - Journal Article DEP - 20260429 PL - Switzerland TA - Sports (Basel) JT - Sports (Basel, Switzerland) JID - 101722684 PMC - PMC13210542 OTO - NOTNLM OT - balance assessment OT - construct validity OT - reliability OT - rhythmic gymnastics OT - sport-specific testing COIS- The authors declare no conflicts of interest. EDAT- 2026/05/26 17:42 MHDA- 2026/05/26 17:43 PMCR- 2026/04/29 CRDT- 2026/05/26 09:53 PHST- 2026/03/07 00:00 [received] PHST- 2026/04/20 00:00 [revised] PHST- 2026/04/22 00:00 [accepted] PHST- 2026/05/26 17:43 [medline] PHST- 2026/05/26 17:42 [pubmed] PHST- 2026/05/26 09:53 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - sports14050178 [pii] AID - sports-14-00178 [pii] AID - 10.3390/sports14050178 [doi] PST - epublish SO - Sports (Basel). 2026 Apr 29;14(5):178. doi: 10.3390/sports14050178. PMID- 42187309 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260915 IS - 1539-2570 (Electronic) IS - 0271-6798 (Linking) VI - 46 IP - 9 DP - 2026 Oct 1 TI - Sports Participation Among Children and Adolescents Following Treatment With the Ponseti Method for Idiopathic Clubfoot: A Multicenter Survey Study. PG - e836-e841 LID - 10.1097/BPO.0000000000003323 [doi] AB - BACKGROUND: Idiopathic clubfoot is a complex congenital foot and ankle anomaly commonly treated with the Ponseti method. While gross motor function and activity level are similar in children with clubfoot treated with this method compared with children without clubfoot, data are lacking on sports participation following this treatment. This study aimed to describe the prevalence of sports participation among children with idiopathic clubfoot treated with the Ponseti method. METHODS: This was a multicenter retrospective cross-sectional study. Patients aged 5 to 17 years were included if they had been diagnosed with idiopathic clubfoot and treated with the Ponseti method during infancy. Parents of subjects were asked to complete a 1-time REDCap survey that included basic demographic questions, 2 validated activity scores (PROMIS Physical Activity Short Form and PACE+), and questions relating to sports participation. The comparison group consisted of the siblings of patients with clubfoot. RESULTS: One hundred fifty-one patients with clubfoot and 45 siblings without clubfoot were included from 4 institutions. In the clubfoot group, 72.2% of participants were male compared with 60% in the sibling group ( P =0.12). Median PROMIS-PA t-scores were 53.3 [interquartile range (IQR) 8.6] and 56.3 (IQR 13.2) in the clubfoot and sibling groups, respectively ( P =0.016). The median PACE+ scores were 4 (IQR 3.5) in the clubfoot group and 4.75 (IQR 2.75) ( P =0.261) in the sibling group. Sports participation was reported in 120 (79.5%) patients with clubfoot and 43 siblings (95.6%) ( P =0.006). Soccer, baseball, basketball, football, and swimming were the most commonly played sports in both groups. CONCLUSIONS: Children treated for idiopathic clubfoot with the Ponseti method remain active and participate in sports similar to their siblings. Further prospective studies examining sports participation and injury prevalence are needed to better understand long-term clinical and functional outcomes in patients treated with the Ponseti method for idiopathic clubfoot. STUDY DESIGN: Retrospective. LEVEL OF EVIDENCE: Level IV. CI - Copyright (c) 2026 Wolters Kluwer Health, LLC. All rights reserved. FAU - Weihe, James AU - Weihe J AD - Children's Mercy Kansas, Kansas City, MO. FAU - Bent, Melissa AU - Bent M AD - Children's Hospital Los Angeles, Los Angeles, CA. FAU - Kent, Lindsey AU - Kent L AD - Children's Hospital of Wisconsin, Milwaukee, Medical College of Wisconsin Affiliated Hospitals. FAU - Padilla, Abigail AU - Padilla A AD - Children's Hospital Los Angeles, Los Angeles, CA. FAU - Margherio, Shannon AU - Margherio S AD - Children's Mercy Kansas, Kansas City, MO. FAU - Carl, Rebecca AU - Carl R AD - Lurie Children's Hospital, Chicago, IL. FAU - Masrouha, Karim AU - Masrouha K AD - NYU Langone Orthopaedic Hospital, New York, NY. FAU - Lang, Pamela AU - Lang P AD - Shriners Children's Hospital, Twin Cities, Woodbury. FAU - Nemeth, Blaise AU - Nemeth B AD - Department of Orthopaedics and Rehabilitation, University of Wisconsin, Madison, WI. FAU - Stork, Natalie AU - Stork N AD - Department of Pediatrics, University of Minnesota, Gillette Children's Hospital, St. Paul, MN. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260526 PL - United States TA - J Pediatr Orthop JT - Journal of pediatric orthopedics JID - 8109053 SB - IM MH - Humans MH - *Clubfoot/surgery/therapy MH - Child MH - Retrospective Studies MH - Male MH - Cross-Sectional Studies MH - Adolescent MH - Female MH - Child, Preschool MH - *Sports/statistics & numerical data MH - Casts, Surgical MH - Treatment Outcome MH - Surveys and Questionnaires OTO - NOTNLM OT - Ponseti method OT - clubfoot OT - sports participation COIS- The authors declare no conflicts of interest. EDAT- 2026/05/26 17:41 MHDA- 2026/09/09 11:38 CRDT- 2026/05/26 09:13 PHST- 2025/10/16 00:00 [received] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/09/09 11:38 [medline] PHST- 2026/05/26 17:41 [pubmed] PHST- 2026/05/26 09:13 [entrez] AID - 01241398-990000000-01179 [pii] AID - 10.1097/BPO.0000000000003323 [doi] PST - ppublish SO - J Pediatr Orthop. 2026 Oct 1;46(9):e836-e841. doi: 10.1097/BPO.0000000000003323. Epub 2026 May 26. PMID- 42187247 OWN - NLM STAT- Publisher LR - 20260526 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) DP - 2026 May 26 TI - Parents' perception of child's weight status, key to dietary habits' shaping: An epidemiological study. PG - 2601060261444653 LID - 10.1177/02601060261444653 [doi] AB - BackgroundDietary habits are one of the main factors in the prevention of chronic diseases, starting in childhood.AimThe present study investigated the possibility of an association between parents' perception of their children's body weight and their daily macronutrients and energy intakes.MethodsThe study sample consisted of 1073 parent-child pairs in Greece, with a mean age of the latter 11.18 +/- 0.818 years. The body mass index of children was calculated using weight and height, and classified using the cut-off criteria established by the World Obesity Federation. Dietary habits were evaluated with the semi-quantitative validated food frequency questionnaire, containing 21 items. Parental body weight perception of children determined by a researcher-made questionnaire. After anthropometric assessment, children were classified into two categories (normal vs. overweight/obesity).ResultsTwo hundred sixty-two children (24.4%) were living with an increased body weight. However, only 52.3% of the parents stated that they were aware of the fact, with the remaining percentage considering the weight as normal. Linear regression analysis showed a statistically significant correlation only between the parents' perception and the children's protein and fat intake (p = 0.021 and 0.015, respectively), an association that remained after the inclusion of confounding factors (p = 0.016 and p = 0.016, respectively).ConclusionParents' perceptions of their child's weight status appear to influence their child's dietary intake. Recognizing the existence of this relationship provides the impetus for reshaping children's diets and preventing childhood obesity. FAU - Kokkou, Stamatia AU - Kokkou S AUID- ORCID: 0000-0003-0717-3222 AD - Department of Public and Community Health, Laboratory of Hygiene and Epidemiology, School of Public Health, University of West Attica, Athens, Greece. RINGGOLD: 607347 FAU - Kanellopoulou, Aikaterini AU - Kanellopoulou A AUID- ORCID: 0000-0002-4766-6040 AD - Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, Athens, Greece. RINGGOLD: 68996 FAU - Antonogeorgos, George AU - Antonogeorgos G AUID- ORCID: 0000-0002-0515-7256 AD - Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, Athens, Greece. RINGGOLD: 68996 FAU - Rojas-Gil, Andrea Paola AU - Rojas-Gil AP AUID- ORCID: 0000-0002-9812-2131 AD - Department of Nursing, Faculty of Health Sciences, University of Peloponnese, Tripoli, Greece. FAU - Kornilaki, Ekaterina N AU - Kornilaki EN AUID- ORCID: 0000-0003-1723-7453 AD - Department of Preschool Education, School of Education, University of Crete, Rethimno, Greece. FAU - Lagiou, Areti AU - Lagiou A AUID- ORCID: 0000-0002-6687-358X AD - Department of Public and Community Health, Laboratory of Hygiene and Epidemiology, School of Public Health, University of West Attica, Athens, Greece. RINGGOLD: 607347 FAU - Panagiotakos, Demosthenes AU - Panagiotakos D AUID- ORCID: 0000-0001-8583-153X AD - Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, Athens, Greece. RINGGOLD: 68996 FAU - Notara, Venetia AU - Notara V AUID- ORCID: 0000-0002-4080-8392 AD - Department of Public and Community Health, Laboratory of Hygiene and Epidemiology, School of Public Health, University of West Attica, Athens, Greece. RINGGOLD: 607347 LA - eng PT - Journal Article DEP - 20260526 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 SB - IM OTO - NOTNLM OT - Children OT - body weight OT - overweight/obesity OT - parents OT - weight perception EDAT- 2026/05/26 17:41 MHDA- 2026/05/26 17:41 CRDT- 2026/05/26 09:03 PHST- 2026/05/26 17:41 [medline] PHST- 2026/05/26 17:41 [pubmed] PHST- 2026/05/26 09:03 [entrez] AID - 10.1177/02601060261444653 [doi] PST - aheadofprint SO - Nutr Health. 2026 May 26:2601060261444653. doi: 10.1177/02601060261444653. PMID- 42187188 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260922 IS - 2314-6141 (Electronic) IS - 2314-6133 (Print) VI - 2026 IP - 1 DP - 2026 TI - Differential Effects of Individually Adapted Challenge-Oriented Heidelberg Ballschule Activities Versus Static Version on Motor Competence and Affective Engagement in 9-11-Year-Old Female Children. PG - e5244454 LID - 10.1155/bmri/5244454 [doi] LID - 5244454 AB - The widespread decline in motor competence and habitual physical activity (PA) among children underscores the need for innovative, intrinsically motivating pedagogical interventions. This quasiexperimental study examined the differential effects of two variants of the Heidelberg Ballschule program-one featuring individually adapted, challenge-oriented progression aligned with participants' optimal challenge points, and the other using static, nonprogressive tasks-on motor competence, affective engagement (enjoyment of PA), and weekly PA levels in 9-11-year-old female children in Kermanshah, Iran. Thirty girls aged 9-11 years were randomly assigned to either the challenge-oriented group (n = 15) or the static group (n = 15). Both groups engaged in Heidelberg Ballschule ball activities for 8 weeks (three sessions/week, 45-60 min/session). Motor competence was assessed pre- and postintervention using a standardized tool (e.g., Bruininks-Oseretsky Test of Motor Proficiency), affective engagement via a validated enjoyment questionnaire, and PA levels throughout the intervention period via self-report (Physical Activity Questionnaire for Children [PAQ-C]). Results indicated that the challenge-oriented group significantly outperformed the static group in overall motor competence (including gross and fine motor components), reported higher levels of affective engagement/enjoyment during PA, and exhibited greater weekly PA levels. These findings provide preliminary evidence that individually adapted, challenge-oriented Heidelberg Ballschule activities-grounded in the challenge point framework-effectively enhance motor competence, foster positive affective responses to PA, and promote increased PA participation in preadolescent girls. Such approaches hold promise for integration into school-based physical education programs to address motor and activity deficits. CI - Copyright (c) 2026 Neda Mohammad Veysi et al. BioMed Research International published by John Wiley & Sons Ltd. FAU - Veysi, Neda Mohammad AU - Veysi NM AD - Department of Motor Behaviour, Faculty of Sport Sciences, Razi University, Kermanshah, Iran, razi.ac.ir. FAU - Sabaghi, Ayoob AU - Sabaghi A AUID- ORCID: 0000-0002-5599-1986 AD - Department of Motor Behaviour, Faculty of Sport Sciences, Razi University, Kermanshah, Iran, razi.ac.ir. FAU - Ebrahimi, Behrooz AU - Ebrahimi B AUID- ORCID: 0000-0002-1250-3313 AD - Department of Motor Behaviour, Faculty of Sport Sciences, Razi University, Kermanshah, Iran, razi.ac.ir. LA - eng PT - Journal Article PL - United States TA - Biomed Res Int JT - BioMed research international JID - 101600173 SB - IM MH - Humans MH - Child MH - Female MH - *Motor Skills/physiology MH - *Exercise/physiology MH - *Affect/physiology MH - Iran PMC - PMC13202726 OTO - NOTNLM OT - Heidelberg Ballschule OT - affective engagement OT - challenge point framework OT - motor competence OT - physical activity OT - preadolescent girls COIS- The authors declare no conflicts of interest. EDAT- 2026/05/26 17:41 MHDA- 2026/05/26 23:33 PMCR- 2026/05/26 CRDT- 2026/05/26 08:33 PHST- 2025/12/13 00:00 [revised] PHST- 2024/11/14 00:00 [received] PHST- 2026/02/20 00:00 [accepted] PHST- 2026/05/26 23:33 [medline] PHST- 2026/05/26 17:41 [pubmed] PHST- 2026/05/26 08:33 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - BMRI5244454 [pii] AID - 10.1155/bmri/5244454 [doi] PST - ppublish SO - Biomed Res Int. 2026;2026(1):e5244454. doi: 10.1155/bmri/5244454. PMID- 42186028 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260813 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 25 IP - 1 DP - 2026 May 25 TI - Gut microbiota and western dietary patterns associated with behavioral problems in children and adolescents: a cross-sectional study. LID - 10.1186/s12937-026-01335-5 [doi] LID - 80 AB - BACKGROUND: Childhood and adolescence are crucial periods for brain development, during which multiple environmental factors, including gut microbiota and dietary habits, play important roles. However, the combined impact of those factors on neurodevelopment and mental disease risk remains largely unexplored. Here, we aimed to investigate the relationships between gut microbiota and diet and their role in classifying behavioral problems that may precede mental disorders in children and adolescents. METHODS: We performed a cross-sectional study, including data from 335 subjects, including 202 children (5-10 years) and 133 adolescents (11-17 years). Gut microbiota was analysed in stools by shotgun metagenomics. Dietary habits, lifestyle factors and emotional and behavioral difficulties were screened using validated questionnaires. Penalized Logistic Regression models were trained to classify individuals into Healthy and Behavioral Problem groups based on microbial diversity, differential abundance of bacterial species, dietary patterns, and food and nutrient intakes. Mediation analyses were applied to assess whether gut microbiota mediates the effect of diet on behavioral problems. RESULTS: A Western diet characterized by poor adherence to dietary recommendations was consistently associated with behavioral problems in all age groups. Individuals with behavioral problems exhibited distinct gut microbiota profiles characterized by lower levels of short-chain fatty acid-producing bacteria (particularly butyrate-producing species) and higher levels of potential pathogens (e.g., Campylobacter coli and Lautropia mirabilis), linked to poor dietary choices. Furthermore, we evidenced the mediation role of the gut microbiota in the association between dietary patterns and food groups and behavioral problems. In adolescents, L. mirabilis was identified as a mediator of the relationship between a Western diet and behavioral problems, while Anaerostipes rhamnosivorans mediated the relationship between fish consumption and behavioral problems. Gut microbiota data enhanced the classification accuracy of logistic regression models for identifying individuals with behavioral problems over models based solely on dietary data. CONCLUSION: Integrating dietary habits and gut microbiota data enables more accurate stratification of children and adolescents at risk for behavioral problems. Our findings may help to refine dietary interventions targeting the gut microbiota to improve mental health outcomes in these vulnerable populations. CI - (c) 2026. The Author(s). FAU - Larroya, A AU - Larroya A AD - Microbiome Innovation in Nutrition & Health, Institute of Agrochemistry and Food Technology, Spanish National Research Council (IATA-CSIC), Avda. Agustin Escardino, 7, Valencia, Paterna, 46980, Spain. FAU - Romera-Giner, S AU - Romera-Giner S AD - Microbiome Innovation in Nutrition & Health, Institute of Agrochemistry and Food Technology, Spanish National Research Council (IATA-CSIC), Avda. Agustin Escardino, 7, Valencia, Paterna, 46980, Spain. FAU - Tolosa-Enguis, V AU - Tolosa-Enguis V AD - Microbiome Innovation in Nutrition & Health, Institute of Agrochemistry and Food Technology, Spanish National Research Council (IATA-CSIC), Avda. Agustin Escardino, 7, Valencia, Paterna, 46980, Spain. FAU - Rodriguez-Ruano, S M AU - Rodriguez-Ruano SM AD - Microbiome Innovation in Nutrition & Health, Institute of Agrochemistry and Food Technology, Spanish National Research Council (IATA-CSIC), Avda. Agustin Escardino, 7, Valencia, Paterna, 46980, Spain. FAU - Andres-Garcia, S AU - Andres-Garcia S AD - Neurological Rehabilitation Center, Limbic, Valencia, 46015, Spain. FAU - Soro-Conde, I AU - Soro-Conde I AD - Neurological Rehabilitation Center, Limbic, Valencia, 46015, Spain. FAU - Codoner, P AU - Codoner P AD - Deparment of Pediatrics, Dr. Peset University Hospital, Avd. De Gaspar Aguilar, 80, Valencia, 46017, Spain. AD - Deparment of Pediatrics, Obstetrics and Gynecology, University of Valencia, Valencia, Spain. FAU - Sanz, Y AU - Sanz Y AD - Microbiome Innovation in Nutrition & Health, Institute of Agrochemistry and Food Technology, Spanish National Research Council (IATA-CSIC), Avda. Agustin Escardino, 7, Valencia, Paterna, 46980, Spain. yolsanz@iata.csic.es. LA - eng PT - Journal Article DEP - 20260525 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Child MH - Adolescent MH - Female MH - Male MH - *Gastrointestinal Microbiome/physiology MH - *Diet, Western/adverse effects MH - Child, Preschool MH - Feces/microbiology MH - Feeding Behavior MH - *Problem Behavior PMC - PMC13412121 OTO - NOTNLM OT - Behavior OT - Fibers OT - Gut-brain axis OT - Microbiota OT - Short-chain fatty acids OT - Western diet COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Medical Ethical Committee of Hospital Dr Peset in Valencia (approval number 131/20). The study was conducted following the code of ethics of the World Medical Association (Declaration of Helsinki) and ensuring data protection. All parents of children and adolescents provided written informed consent. In addition, participants over 12 years of age also provided their consent. Clinical trial number not applicable. STROBE recommendations were followed for data reporting. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/26 06:31 MHDA- 2026/07/30 12:42 PMCR- 2026/05/25 CRDT- 2026/05/26 00:06 PHST- 2025/05/09 00:00 [received] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/07/30 12:42 [medline] PHST- 2026/05/26 06:31 [pubmed] PHST- 2026/05/26 00:06 [entrez] PHST- 2026/05/25 00:00 [pmc-release] AID - 10.1186/s12937-026-01335-5 [pii] AID - 1335 [pii] AID - 10.1186/s12937-026-01335-5 [doi] PST - epublish SO - Nutr J. 2026 May 25;25(1):80. doi: 10.1186/s12937-026-01335-5. PMID- 42185601 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260828 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 May 25 TI - Sonographic evaluation of fetal abdominal subcutaneous tissue in pregnancies complicated by gestational and type 1 diabetes mellitus. LID - 10.1038/s41598-026-54402-6 [doi] LID - 23825 AB - To perform a comparative analysis of fetal abdominal fat mass (AFM) thickness in women diagnosed with gestational (GDM) and type 1 diabetes mellitus (T1DM), and to evaluate the efficacy of the ultrasonographic AFM measurement in the estimation of the fetal birth-weight (FBW) and prediction of fetal macrosomia. A total of 245 participants were recruited for this prospective observational cohort study, including women with diet-controlled GDM (GDMG1) (n = 50), insulin-controlled GDM (GDMG2) (n = 50), T1DM (n = 50) as well as non-diabetic control patients (n = 95). In each participant measurements of the AFM in conjunction with the standard fetal biometric parameters were performed within the 72 h period prior to delivery. Fetal macrosomia was defined as birth-weight >/= 4000 g irrespective of gestational age. After adjustment for confounding factors, median AFM and abdominal circumference (AC) measurements as well as the FBW were significantly higher among patients with T1DM as compared to other groups (p < 0.05). In each group both AFM and AC measurements showed strong positive correlations with the FBW (p < 0.001). Two new models comprising maternal (body mass index) and/or ultrasound-derived parameters (biparietal diameter, AC, AFM) for the FBW estimation were constructed. Both equations provided significantly lower mean absolute percent error among GDMG1 and T1DM women as compared to the Hadlock formula (p < 0.05). In addition novel equation for the prediction of fetal macrosomia, utilizing both AC and AFM measurements, yielded sensitivity of 84.8%, specificity 91.9%, positive predictive value 62.2% and negative predictive value of 97.5% within the total study population. In women with GDM/T1DM, the incorporation of the AFM measurement into equations for the FBW estimation provided better accuracy compared to standard formulas and increased the detection of fetal macrosomia. Further validation in large-scale multicenter studies is necessary prior to clinical implementation. CI - (c) 2026. The Author(s). FAU - Sliwka, Aleksandra AU - Sliwka A AD - 1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Starynkiewicza Sq. 1/3, 02-015, Warsaw, Poland. FAU - Makowska, Katarzyna AU - Makowska K AD - 1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Starynkiewicza Sq. 1/3, 02-015, Warsaw, Poland. FAU - Litwinska-Korcz, Ewelina AU - Litwinska-Korcz E AD - 1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Starynkiewicza Sq. 1/3, 02-015, Warsaw, Poland. FAU - Litwinska, Magdalena AU - Litwinska M AD - 1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Starynkiewicza Sq. 1/3, 02-015, Warsaw, Poland. FAU - Stanirowski, Pawel Jan AU - Stanirowski PJ AUID- ORCID: 0000-0001-7445-7546 AD - 1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Starynkiewicza Sq. 1/3, 02-015, Warsaw, Poland. stanirowski@gmail.com. LA - eng PT - Journal Article PT - Observational Study DEP - 20260525 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Diabetes Mellitus, Type 1/diagnostic imaging/complications MH - Adult MH - *Fetal Macrosomia/diagnostic imaging MH - *Ultrasonography, Prenatal/methods MH - *Diabetes, Gestational/diagnostic imaging MH - Birth Weight MH - Prospective Studies MH - *Subcutaneous Fat, Abdominal/diagnostic imaging MH - *Fetus/diagnostic imaging MH - Infant, Newborn PMC - PMC13434002 OTO - NOTNLM OT - Fetal abdominal subcutaneous tissue OT - Fetal birth-weight OT - Fetal macrosomia OT - Fetal soft-tissue OT - Gestational diabetes mellitus OT - Type 1 diabetes mellitus OT - Ultrasound COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki Ethical Principles and Good Clinical Practices. The Local Ethics Committee of the Medical University of Warsaw approved the study, and all participants signed their written informed consent (ref no. KB/36/2022). Competing interests: The authors declare no competing interests. EDAT- 2026/05/26 00:29 MHDA- 2026/08/04 00:35 PMCR- 2026/05/25 CRDT- 2026/05/25 23:29 PHST- 2025/10/26 00:00 [received] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/08/04 00:35 [medline] PHST- 2026/05/26 00:29 [pubmed] PHST- 2026/05/25 23:29 [entrez] PHST- 2026/05/25 00:00 [pmc-release] AID - 10.1038/s41598-026-54402-6 [pii] AID - 54402 [pii] AID - 10.1038/s41598-026-54402-6 [doi] PST - epublish SO - Sci Rep. 2026 May 25;16(1):23825. doi: 10.1038/s41598-026-54402-6. PMID- 42183855 OWN - NLM STAT- MEDLINE DCOM- 20260712 LR - 20261010 IS - 1432-1998 (Electronic) IS - 0301-0449 (Linking) VI - 56 IP - 7 DP - 2026 Jun TI - Increased parotid microvascularity without stiffness differences in children with celiac disease. PG - 1536-1546 LID - 10.1007/s00247-026-06641-y [doi] AB - BACKGROUND: Celiac disease is a systemic autoimmune disorder that can affect salivary glands, yet subclinical involvement in children is under-investigated. Conventional ultrasound often lacks sensitivity for detecting early inflammatory or subtle microvascular changes in asymptomatic patients. OBJECTIVE: We aimed to evaluate subclinical parotid gland involvement in children with celiac disease using microvascular imaging and shear wave elastography (SWE), hypothesizing that these tools could detect early parenchymal and microcirculatory alterations. MATERIALS AND METHODS: This prospective, cross-sectional case-control study included 78 children with biopsy-confirmed celiac disease and 72 age- and body mass index-matched healthy controls. Bilateral parotid microvascularity index (MVI, %) and tissue stiffness (SWE, kPa) were assessed using high-resolution ultrasonography by an experienced radiologist who was blinded to the group allocation and clinical data. Between-group comparisons were performed using two-sided Mann-Whitney U tests. Within the celiac disease group, imaging metrics were explored according to gluten-free diet duration, serum tissue transglutaminase IgA (tTG-IgA) levels, and modified Marsh grade. RESULTS: The MVI was higher in the celiac disease group for both the left (median [interquartile range], 5.29 [3.12-10.80] vs 2.00 [1.03-4.78]; P<0.001) and right (4.55 [2.42-10.82] vs 3.25 [0.90-5.48]; P=0.001) parotid glands. However, SWE did not differ significantly between groups (left P=0.21; right P=0.09). Within the celiac disease group, imaging metrics were not significantly associated with tTG-IgA levels or Marsh subtypes (all P>0.05). CONCLUSION: Pediatric celiac disease is associated with increased parotid microvascularity without detectable stiffness differences, suggesting subclinical microvascular alterations. These exploratory findings warrant longitudinal validation to clarify temporal dynamics and clinical relevance. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Ergen, Yasin Maruf AU - Ergen YM AD - Department of Pediatric Gastroenterology, Gulhane Training and Research Hospital, General Dr. Tevfik Saglam Cad. No: 11, Etlik, Kecioren, Ankara, 06018, Turkey. yasinmaruf@gmail.com. FAU - Teke, Selcuk AU - Teke S AD - Department of Pediatric Gastroenterology, Gulhane Training and Research Hospital, General Dr. Tevfik Saglam Cad. No: 11, Etlik, Kecioren, Ankara, 06018, Turkey. FAU - Cavis, Tugba AU - Cavis T AD - Gulhane Training and Research Hospital, Department of Radiology, Saglik Bilimleri Universitesi, Ankara, Turkey. FAU - Basaran, Edibe Gozde AU - Basaran EG AD - Department of Pediatric Gastroenterology, Gulhane Training and Research Hospital, General Dr. Tevfik Saglam Cad. No: 11, Etlik, Kecioren, Ankara, 06018, Turkey. FAU - Akcay, Birce Izgi AU - Akcay BI AD - Department of Pediatric Gastroenterology, Gulhane Training and Research Hospital, General Dr. Tevfik Saglam Cad. No: 11, Etlik, Kecioren, Ankara, 06018, Turkey. FAU - Balamtekin, Necati AU - Balamtekin N AD - Department of Pediatric Gastroenterology, Gulhane Training and Research Hospital, General Dr. Tevfik Saglam Cad. No: 11, Etlik, Kecioren, Ankara, 06018, Turkey. LA - eng PT - Journal Article DEP - 20260525 PL - Germany TA - Pediatr Radiol JT - Pediatric radiology JID - 0365332 SB - IM MH - Humans MH - *Celiac Disease/diagnostic imaging/pathology MH - Female MH - Male MH - *Elasticity Imaging Techniques/methods MH - *Parotid Gland/diagnostic imaging/blood supply MH - Cross-Sectional Studies MH - Prospective Studies MH - Case-Control Studies MH - Child MH - *Microvessels/diagnostic imaging MH - Child, Preschool MH - Adolescent MH - Microcirculation OTO - NOTNLM OT - Celiac disease OT - Children OT - Microvascular imaging OT - Parotid gland OT - Shear wave elastography COIS- Declarations. Consent to participate: Written informed consent was obtained from parents or legal guardians prior to participation, and assent was obtained from children whenever applicable. Conflicts of interest: None EDAT- 2026/05/25 12:35 MHDA- 2026/07/13 00:32 CRDT- 2026/05/25 11:02 PHST- 2025/12/30 00:00 [received] PHST- 2026/05/03 00:00 [accepted] PHST- 2026/04/07 00:00 [revised] PHST- 2026/07/13 00:32 [medline] PHST- 2026/05/25 12:35 [pubmed] PHST- 2026/05/25 11:02 [entrez] AID - 10.1007/s00247-026-06641-y [pii] AID - 10.1007/s00247-026-06641-y [doi] PST - ppublish SO - Pediatr Radiol. 2026 Jun;56(7):1536-1546. doi: 10.1007/s00247-026-06641-y. Epub 2026 May 25. PMID- 42183298 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - Serum and cerebrospinal fluid neuroinflammatory biomarkers and trimethylamine N-oxide: associations with white matter lesion severity. PG - 1799968 LID - 10.3389/fimmu.2026.1799968 [doi] LID - 1799968 AB - INTRODUCTION: This study aimed to investigate the association between a multi-panel biomarker profile across the blood-brain barrier and the severity of white matter lesions (WML) in 42 patients [mean age: 60.3 +/- 12.1 years; 45.2% male], suggesting a potential inflammatory endotype rather than defining a distinct phenotype due to the cross-sectional design and limited sample size. We assessed the gut-brain axis role in WML pathogenesis through analysis of paired serum and cerebrospinal fluid samples. METHODS: In this cross-sectional clinical study, 42 patients (aged 16-78 years; inclusion of younger subjects was based on radiological confirmation of WML unrelated to acute cerebrovascular events) with radiologically confirmed WML were stratified into four severity groups based on combined Fazekas global score (range 0-3, incorporating both periventricular and deep white matter hyperintensities). Levels of six biomarkers-interleukin-1beta (IL-1beta), matrix metalloproteinase-2 (MMP-2), tumor necrosis factor-alpha (TNF-alpha), trimethylamine N-oxide (TMAO), S100 calcium-binding protein beta (S100beta), and immunoglobulin G (IgG)-were simultaneously quantified in paired serum and cerebrospinal fluid (CSF) samples using ELISA. Statistical analyses included: (1) group comparisons using one-way ANOVA with LSD post-hoc tests; (2) Spearman correlation analyses; (3) multivariable ordinal logistic regression adjusting for age, sex, hypertension, diabetes, and BMI to control confounding; (4) False Discovery Rate (FDR) correction for multiple comparisons (Benjamini-Hochberg method). Post-hoc power analysis and effect sizes (eta(2), Cohen's d) were reported. RESULTS: Severity-dependent increases in IL-1beta, TNF-alpha, and the gut-derived metabolite TMAO were observed in both serum and CSF. After adjustment for confounders, CSF TNF-alpha (adjusted OR = 1.95, 95% CI: 1.42-2.68, P<0.001) and serum MMP-2 (adjusted OR = 1.72, 95% CI: 1.28-2.31, P<0.001) demonstrated the strongest correlations with WML severity among all biomarkers, establishing them as primary candidate biomarkers. An inverse concentration pattern (elevated serum/decreased CSF) was observed for MMP-2, suggesting stage-specific roles in blood-brain barrier dynamics. CSF S100beta levels increased with severity (r=0.487, P<0.001), consistent with parenchymal injury. Regarding IgG, while univariate analysis showed marginal significance in CSF (P = 0.045), FDR correction rendered this non-significant (q=0.12), and no significant correlation was found with Fazekas grade (P = 0.068), suggesting limited association with WML severity in this cohort. CONCLUSION: This study suggests a potential neuroinflammatory profile in WML, characterized by coupled peripheral and central inflammation associated with gut-derived TMAO, though causality cannot be inferred from this cross-sectional design. CSF TNF-alpha and serum MMP-2 are proposed as precision biomarkers for stratifying WML severity. These findings should be interpreted as a hypothesis-generating framework integrating dysregulated gut-brain axis signaling, central cytokine surges, and blood-brain barrier disruption into a unified pathogenic cascade, providing mechanistic insights for targeted anti-inflammatory strategies in cerebrovascular disease. However, the clinical applicability requires further validation given the invasive nature of CSF collection. CI - Copyright (c) 2026 Cheng, Luo, Zhang, Xiao, An and Qu. FAU - Cheng, Xinxin AU - Cheng X AD - Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. FAU - Luo, Changjiang AU - Luo C AD - Department of Neurology, Jinan Shizhong District People's Hospital, Jinan, China. FAU - Zhang, Xudong AU - Zhang X AD - Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. FAU - Xiao, Huicong AU - Xiao H AD - Department of Neurology, The Third Affiliated Hospital of Shandong First Medical University, Jinan, China. FAU - An, Qi AU - An Q AD - Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. FAU - Qu, Chuanqiang AU - Qu C AD - Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. LA - eng PT - Journal Article DEP - 20260508 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (Biomarkers) RN - 0 (Methylamines) RN - FLD0K1SJ1A (trimethyloxamine) RN - 0 (Tumor Necrosis Factor-alpha) SB - IM MH - Humans MH - Male MH - Middle Aged MH - *Biomarkers/cerebrospinal fluid/blood MH - Female MH - Adult MH - *Methylamines/blood/cerebrospinal fluid MH - Cross-Sectional Studies MH - Aged MH - *White Matter/pathology/diagnostic imaging MH - Adolescent MH - *Neuroinflammatory Diseases/cerebrospinal fluid/blood MH - Severity of Illness Index MH - Young Adult MH - Blood-Brain Barrier/metabolism MH - Tumor Necrosis Factor-alpha/blood/cerebrospinal fluid PMC - PMC13193994 OTO - NOTNLM OT - blood-brain barrier OT - gut-brain axis OT - neuroinflammation biomarkers OT - trimethylamine N-oxide OT - white matter lesions COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/25 12:35 MHDA- 2026/05/25 12:36 PMCR- 2026/05/08 CRDT- 2026/05/25 08:17 PHST- 2026/01/30 00:00 [received] PHST- 2026/03/27 00:00 [revised] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/05/25 12:36 [medline] PHST- 2026/05/25 12:35 [pubmed] PHST- 2026/05/25 08:17 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1799968 [doi] PST - epublish SO - Front Immunol. 2026 May 8;17:1799968. doi: 10.3389/fimmu.2026.1799968. eCollection 2026. PMID- 42177369 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260821 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 May 23 TI - Effects of exergames on depression, anxiety, and sleep in adolescents with subthreshold depression: a randomized controlled trial. LID - 10.1038/s41598-026-54710-x [doi] LID - 23603 AB - Subthreshold depression (SD) is highly prevalent among adolescents and increases the risk of developing major depressive disorder. Exergaming, an interactive form of digital physical activity, may enhance engagement and improve adherence compared with traditional exercise, making it a promising approach for adolescent mental-health promotion. This randomized controlled trial investigated the effects of an eight-week exergame intervention on depressive symptoms, anxiety, and sleep quality among adolescents with SD. A total of 51 students were randomly assigned to an exergame group (n = 26) or a control group (n = 25). Participants in the exergame group completed moderate-intensity exergaming for 40 min, two to three times per week, while the control group continued routine school activities. Mental-health outcomes were assessed before and after the intervention using validated self-report questionnaires, including the Self-Rating Depression Scale (SDS), the Self-Rating Anxiety Scale (SAS), and the Pittsburgh Sleep Quality Index (PSQI) for subjective sleep quality. After the 8-week intervention, the exergame group showed significantly greater improvements than the control group in depressive symptoms, anxiety, and sleep quality (all p < 0.05). These findings indicate that exergames are an engaging, feasible, and effective school-based strategy for improving mental health in adolescents with SD. As a low-threshold and scalable digital exercise modality, exergaming may offer meaningful benefits for early intervention and mental-health promotion in youth populations. CI - (c) 2026. The Author(s). FAU - Liu, Guofeng AU - Liu G AD - Department of Physical Education, Capital University of Physical Education and Sports, Beijing, China. AD - Department of Technician Education, Shandong Labor Vocational and Technical College, Jinan, Shandong, China. FAU - Jing, Yang AU - Jing Y AD - Department of Fundamental Education, Shandong Labor Vocational and Technical College, Jinan, Shandong, China. FAU - Xie, Jinjian AU - Xie J AD - Department of Technician Education, Shandong Labor Vocational and Technical College, Jinan, Shandong, China. FAU - Xie, Fei AU - Xie F AD - Department of Technician Education, Shandong Labor Vocational and Technical College, Jinan, Shandong, China. FAU - Chen, Dan AU - Chen D AD - Shengjing Primary School, Lixia District, Jinan, Shandong, China. FAU - Zhang, Junping AU - Zhang J AD - Department of Technician Education, Shandong Labor Vocational and Technical College, Jinan, Shandong, China. 13573147555@163.com. LA - eng GR - 2025SZ05/Shandong Labor Vocational and Technical College/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20260523 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Adolescent MH - *Anxiety/therapy MH - *Video Games MH - *Depression/therapy MH - Female MH - Male MH - *Sleep/physiology MH - Sleep Quality MH - *Exercise MH - *Exercise Therapy/methods MH - Surveys and Questionnaires PMC - PMC13421659 OTO - NOTNLM OT - Adolescents OT - Anxiety OT - Exergames OT - Sleep quality OT - Subthreshold depression COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/05/24 04:38 MHDA- 2026/07/30 00:38 PMCR- 2026/05/23 CRDT- 2026/05/23 23:20 PHST- 2025/11/26 00:00 [received] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/07/30 00:38 [medline] PHST- 2026/05/24 04:38 [pubmed] PHST- 2026/05/23 23:20 [entrez] PHST- 2026/05/23 00:00 [pmc-release] AID - 10.1038/s41598-026-54710-x [pii] AID - 54710 [pii] AID - 10.1038/s41598-026-54710-x [doi] PST - epublish SO - Sci Rep. 2026 May 23;16(1):23603. doi: 10.1038/s41598-026-54710-x. PMID- 42176987 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260823 IS - 1541-6100 (Electronic) IS - 0022-3166 (Print) IS - 0022-3166 (Linking) VI - 156 IP - 7 DP - 2026 Jul TI - Total Sugars Misreporting in Self-Reported 24-Hour Recalls in the Study of Latinos: Nutrition and Physical Activity Assessment Study. PG - 101608 LID - S0022-3166(26)00257-9 [pii] LID - 10.1016/j.tjnut.2026.101608 [doi] AB - BACKGROUND: Hispanic and Latinos living in the United States bear a disproportionate burden of chronic diseases previously associated with sugars intake. However, due to measurement error (ME) in self-reported diet, these associations have been difficult to establish. OBJECTIVES: To study ME of self-reported total sugars (TSs) intake, as well as its determinates and effect on estimating diet-disease associations in Hispanics and Latinos living in the United States, we apply the 24-h urinary sucrose and fructose predictive biomarker previously confirmed in a feeding study under United States diet. METHODS: We used data from 443 males and females aged 18 to 74 y of Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American origin living across 4 United States communities who participated in the Study of Latinos: Nutrition and Physical Activity Assessment Study (SOLNAS). Participants completed 3 24-h recalls (24HR) and 1 24-h urine collection for measurement of 24-h urinary sucrose and fructose biomarker. Doubly labeled water was administered once to estimate energy intake. Measures were repeated 6 mo later in a reliability sample (n = 81). ME structure in self-reported TSs was investigated using a time-varying intake ME model adjusted for sex, age, and body mass index. RESULTS: The biomarker-based TSs intake was 171.3 g/d (95% confidence interval: 158.3-185.3) compared with 96.3 g/d (95% confidence interval: 91.7-101.2) estimated by 3 24HRs. The correlation of true intake with mean TSs from 2 24HRs as a measure of usual intake over 0 to 12 mo ranged from 0.19 to 0.21. The attenuation factors for the average of 2 24HRs ranged from 0.08 to 0.16. Age and Hispanic and Latino background were significantly associated with TSs misreporting, whereas, age, Hispanic and Latino background, being male and supplement user were associated with misreporting of TSs density. CONCLUSIONS: In this Hispanic and Latino population, we observed large ME in 24HR-measured TSs consumption that would lead to severe attenuation of estimated risk in future sugars-disease association studies. Applying biomarker-based ME correction approaches may alleviate bias. CI - Copyright (c) 2026 American Society for Nutrition. All rights reserved. FAU - Tasevska, Natasha AU - Tasevska N AD - College of Health Solutions, Arizona State University, Phoenix, AZ, United States. Electronic address: Natasha.Tasevska@asu.edu. FAU - Mossavar-Rahmani, Yasmin AU - Mossavar-Rahmani Y AD - Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, United States. FAU - Midthune, Douglas AU - Midthune D AD - Division of Cancer Prevention, National Cancer Institute, Rockville, MD, United States. FAU - Barrett, Brian AU - Barrett B AD - Information Management Services Inc., Rockville, MD, United States. FAU - Razis, Spiro AU - Razis S AD - Information Management Services Inc., Rockville, MD, United States. FAU - Kipnis, Victor AU - Kipnis V AD - Division of Cancer Prevention, National Cancer Institute, Rockville, MD, United States. FAU - Kaplan, Robert AU - Kaplan R AD - Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, United States. FAU - O'Brien, Diane AU - O'Brien D AD - Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK, United States. FAU - Park, Yikyung AU - Park Y AD - Division of Public Health Sciences, Washington University School of Medicine in St. Louis, St. Louis, MO, United States. FAU - Beasley, Jeannette AU - Beasley J AD - Department of Medicine, New York University, New York, NY, United States. FAU - Van Horn, Linda AU - Van Horn L AD - Feinberg School of Medicine, Northwestern University, Chicago, IL, United States. FAU - Daviglus, Martha AU - Daviglus M AD - Department of Medicine, University of Illinois Chicago, Chicago, IL, United States. FAU - Sotres-Alvarez, Daniela AU - Sotres-Alvarez D AD - Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. FAU - Freedman, Laurence S AU - Freedman LS AD - Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Tel Hashomer, Israel. LA - eng GR - HHSN268201300005C/HL/NHLBI NIH HHS/United States GR - HHSN268201300004C/HL/NHLBI NIH HHS/United States GR - HHSN268201300003I/HL/NHLBI NIH HHS/United States GR - N01 HC065233/HL/NHLBI NIH HHS/United States GR - N01 HC065236/HL/NHLBI NIH HHS/United States GR - N01 HC065235/HL/NHLBI NIH HHS/United States GR - HHSN268201300001C/HB/NHLBI NIH HHS/United States GR - N01 HC065234/HL/NHLBI NIH HHS/United States GR - R01 HL095856/HL/NHLBI NIH HHS/United States GR - U01 CA197902/CA/NCI NIH HHS/United States GR - HHSN268201300003C/HG/NHGRI NIH HHS/United States GR - N01 HC065237/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20260522 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 RN - 0 (Biomarkers) RN - 0 (Dietary Sugars) RN - 30237-26-4 (Fructose) SB - IM MH - Humans MH - Female MH - Male MH - *Hispanic or Latino MH - *Self Report MH - Middle Aged MH - Adult MH - Mental Recall MH - Biomarkers/urine MH - Adolescent MH - Aged MH - *Dietary Sugars/administration & dosage MH - Young Adult MH - United States MH - Nutrition Assessment MH - Fructose/urine MH - Energy Intake MH - Diet MH - Reproducibility of Results PMC - PMC13410787 MID - NIHMS2186708 OTO - NOTNLM OT - 24-h urine biomarker OT - Hispanics OT - SOLNAS OT - measurement error OT - total sugars COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/05/24 04:38 MHDA- 2026/07/08 12:55 PMCR- 2026/07/28 CRDT- 2026/05/23 19:33 PHST- 2026/01/28 00:00 [received] PHST- 2026/04/21 00:00 [revised] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/07/08 12:55 [medline] PHST- 2026/05/24 04:38 [pubmed] PHST- 2026/05/23 19:33 [entrez] PHST- 2026/07/28 00:00 [pmc-release] AID - S0022-3166(26)00257-9 [pii] AID - 10.1016/j.tjnut.2026.101608 [doi] PST - ppublish SO - J Nutr. 2026 Jul;156(7):101608. doi: 10.1016/j.tjnut.2026.101608. Epub 2026 May 22. PMID- 42174502 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1472-6823 (Electronic) IS - 1472-6823 (Linking) VI - 26 IP - 1 DP - 2026 May 22 TI - Development and validation of a predictive model for hypothalamic obesity following craniopharyngioma resection. LID - 10.1186/s12902-026-02322-x [doi] LID - 164 AB - OBJECTIVE: To analyze the risk factors for hypothalamic obesity (HO) after craniopharyngioma surgery, construct a predictive model and verify its efficacy. METHODS: A retrospective analysis was conducted on 136 patients diagnosed with craniopharyngioma at The First Affiliated Hospital of Zhengzhou University between September 2018 and February 2024. Clinical and follow-up data were collected and split into training and validation cohorts (7: 3) randomly and divided into HO and non-HO groups post-surgery. Logistic regression was used to analyse risk factors for postoperative HO, and a prediction model was constructed and its efficacy was verified. RESULTS: In the training cohort, the preoperative body mass index (BMI), preoperative serum sodium, preoperative uric acid levels, postoperative calcium levels, the probability of intraoperative blood loss >/= 100 ml and preoperative hypothalamic injury and T-type tumors were higher in HO group. Small tumors (< 5 cm(3)) were less frequent in HO group (all P < 0.05). Logistic regression analysis showed that preoperative high BMI and intraoperative blood loss >/= 100 ml were independent risk factors for postoperative HO, while older age at onset and smaller tumor size were protective factors (all P < 0.05). The model developed from the training cohort showed that the area under the receiver operating characteristic curve (AUC) was 0.865(95%CI of 0.793 ~ 0.937), with a sensitivity of 79.5% and a specificity of 80.8%, the validation cohort had an AUC of 0.864(95%CI:0.744-0.983), with a sensitivity of 90.9% and a specificity of 72.2%. The calibration curve and Hosmer-Lemeshow test demonstrated that the predicted value of the model was in agreement with the observed values in both the training and verification cohorts (P > 0.05). CONCLUSION: Preoperative high BMI and intraoperative blood loss >/= 100 ml are independent risk factors for HO after craniopharyngioma surgery. A predictive model based on preoperative BMI, age at onset, intraoperative blood loss, and tumor size shows potential for predicting the risk of postoperative HO, aiding in early identification for high-risk patients. CLINICAL TRIAL NUMBER: Not applicable. CI - (c) 2026. The Author(s). FAU - Li, Qianshuai AU - Li Q AD - Department of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. FAU - Zhao, Linlin AU - Zhao L AD - Department of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. FAU - Huang, Fengjuan AU - Huang F AD - Department of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. FAU - Gong, Xuyang AU - Gong X AD - Department of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. FAU - Pan, Mengxing AU - Pan M AD - Department of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. FAU - Liu, Xinjing AU - Liu X AD - Department of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. FAU - Wang, Tianfang AU - Wang T AD - Department of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. FAU - Li, Xulong AU - Li X AD - Department of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. FAU - Xie, Yijing AU - Xie Y AD - Department of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. FAU - Gao, Ankang AU - Gao A AD - Department of Magnetic Resonance, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. FAU - Zhang, Yong AU - Zhang Y AD - Department of Magnetic Resonance, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. FAU - Zhao, Yanyan AU - Zhao Y AD - Department of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. fcczhaoyy1@zzu.edu.cn. AD - Henan Key Laboratory of Chronic Disease Prevention and Therapy & Intelligent Health Management, Zhengzhou, Henan, 450052, China. fcczhaoyy1@zzu.edu.cn. AD - Henan Institute of Interconnected Intelligent Health Management, Zhengzhou, Henan, 450052, China. fcczhaoyy1@zzu.edu.cn. LA - eng GR - 242300421272/Natural Science Foundation of Henan Province/ GR - QNCXTD2023015/Research and Innovation Team Project of the First Affiliated Hospital of Zhengzhou University/ GR - 82470876/National Natural Science Foundation of China/ PT - Journal Article PT - Validation Study DEP - 20260522 PL - England TA - BMC Endocr Disord JT - BMC endocrine disorders JID - 101088676 SB - IM MH - Humans MH - *Craniopharyngioma/surgery/pathology MH - Female MH - Retrospective Studies MH - *Pituitary Neoplasms/surgery/pathology MH - *Postoperative Complications/diagnosis/etiology/epidemiology MH - *Obesity/etiology/diagnosis/epidemiology MH - Male MH - Risk Factors MH - *Hypothalamic Diseases/etiology/diagnosis MH - Follow-Up Studies MH - Prognosis MH - Body Mass Index MH - Adolescent MH - Adult MH - Young Adult MH - Child MH - *Neurosurgical Procedures/adverse effects PMC - PMC13218063 OTO - NOTNLM OT - Body mass index OT - Hypothalamic obesity OT - Postoperative craniopharyngioma OT - Predictive model COIS- Declarations. Human ethics and consent to participate: The study was performed in line with the principles of the Decleration of Helsinki. The study was approved by the ethics committee of the First Affiliated Hospital of Zhengzhou University (No. KY-2024-KY-1086). In compliance with national law and institutional standards, written informed consent was not required and was waived by the ethics committee for this retrospective study. Consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/23 06:31 MHDA- 2026/05/29 15:44 PMCR- 2026/05/22 CRDT- 2026/05/23 00:16 PHST- 2026/02/23 00:00 [received] PHST- 2026/05/13 00:00 [accepted] PHST- 2026/05/29 15:44 [medline] PHST- 2026/05/23 06:31 [pubmed] PHST- 2026/05/23 00:16 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - 10.1186/s12902-026-02322-x [pii] AID - 2322 [pii] AID - 10.1186/s12902-026-02322-x [doi] PST - epublish SO - BMC Endocr Disord. 2026 May 22;26(1):164. doi: 10.1186/s12902-026-02322-x. PMID- 42174465 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 May 22 TI - Development of an interpretable machine learning model for predicting stress urinary incontinence following the delivery of a first child. LID - 10.1186/s12884-026-09285-w [doi] LID - 725 AB - INTRODUCTION: The goal of this research is to use machine learning (ML) techniques to create a risk prediction model for postpartum stress urinary incontinence (PSUI). To improve screening accuracy and optimize clinical care techniques, the goal is to determine the best model for clinical screening. METHODS: Telephone interviews and computerized medical records were used in this study to gather data, which was then combined into a follow-up data form. We recruited women who underwent surface electromyography (sEMG) at Xinjiang Production and Construction Corps Hospital's postpartum rehabilitation clinic between January 2020 and January 2025. A total of 449 primiparous women were included in the study after the inclusion and exclusion criteria were applied. A training set and a validation set were randomly selected from the dataset in a 7:3 ratio. Predictive models for persistent postpartum stress urinary incontinence (PSUI) were created using five machine learning algorithms: logistic regression, decision tree, random forest, support vector machine (SVM), and extreme gradient boosting (XGBoost). Model performance was evaluated using metrics including the area under the receiver operating characteristic curve (AUC). Model interpretability was achieved through SHapley Additive exPlanations (SHAP) analysis. RESULTS: Eight features were kept in the final model: neonatal birth weight, pre-pregnancy BMI, age at delivery, perineal laceration, mean pre-resting phase, mean post-resting phase, maximum fast-twitch phase, and mean slow-twitch phase. Out of the five algorithms, the Random Forest model performed the best, with a test set AUC of 0.920 (95% CI 0.8704-0.9688, P < 0.05), accuracy of 0.8444, precision of 0.6341, recall of 0.8125, specificity of 0.8544, and an F1 score of 0.7123. Ten-fold cross-test and the test set were used to confirm the model's strong generalizability. CONCLUSION: Strong clinical potential for PSUI risk prediction and screening is demonstrated by the random forest model. To further improve the model's clinical usefulness, future research should increase the sample size and include multicenter data. CI - (c) 2026. The Author(s). FAU - Tian, Siwen AU - Tian S AD - The Graduate School of Xinjiang Medical University, Urumqi, 830011, China. FAU - Sha, Jing AU - Sha J AD - Xinjiang Production and Construction Corps Hospital, Urumqi, 830002, China. 13999965869@qq.com. LA - eng PT - Journal Article DEP - 20260522 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - *Urinary Incontinence, Stress/diagnosis/etiology MH - Predictive Learning Models MH - Adult MH - Pregnancy MH - Boosting Machine Learning Algorithms MH - Random Forest MH - Logistic Models MH - Electromyography MH - Prediction Algorithms MH - *Machine Learning MH - Classification Algorithms MH - Support Vector Machine MH - Postpartum Period MH - Risk Assessment/methods MH - ROC Curve MH - *Puerperal Disorders/diagnosis MH - Risk Factors MH - *Delivery, Obstetric/adverse effects PMC - PMC13343770 OTO - NOTNLM OT - Machine learning OT - Postpartum period OT - Predictive model OT - Risk assessment OT - Stress urinary incontinence COIS- Declarations. Ethics approval and consent to participate: This study protocol was reviewed and approved by the Ethics Committee of Xinjiang Production and Construction Corps Hospital (Approval No.: 202408601). The committee confirmed that the study qualified for an exemption from full ethical review due to its retrospective nature, and consequently waived the requirement for informed consent. All procedures performed in this study were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments. Competing interests: The authors declare no competing interests. EDAT- 2026/05/23 06:33 MHDA- 2026/07/08 18:52 PMCR- 2026/05/22 CRDT- 2026/05/23 00:14 PHST- 2026/02/17 00:00 [received] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/07/08 18:52 [medline] PHST- 2026/05/23 06:33 [pubmed] PHST- 2026/05/23 00:14 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - 10.1186/s12884-026-09285-w [pii] AID - 9285 [pii] AID - 10.1186/s12884-026-09285-w [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 May 22;26(1):725. doi: 10.1186/s12884-026-09285-w. PMID- 42174365 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1550-9397 (Electronic) IS - 1550-9389 (Print) IS - 1550-9389 (Linking) VI - 22 IP - 1 DP - 2026 May 22 TI - Actigraphic estimates of sleep duration in those reporting sleeping less than 7 h. LID - 10.1007/s44470-026-00072-0 [doi] LID - 83 AB - OBJECTIVES: Sleep duration < 7 h increases risk for chronic disease, which makes identifying short sleep duration critical to public health. The goal of this study is to evaluate objective short sleep duration among individuals who self-report insufficient sleep to test and evaluate predictors of the subjective-objective sleep duration difference. METHODS: This study presents baseline data from a sleep extension study involving adults aged 18-65, fluency in English, and self-reported sleep duration /= 7 h/day. Descriptive statistics and logistic regression analyses were performed to identify factors associated with prolonged sedentary behavior. RESULTS: The mean daily sedentary time was 326.3 +/- 211.4 min, and 28.6% of students reported prolonged sedentary behavior. Watching television was the most common sedentary activity, followed by academic work and phone use. Sedentary time was higher among females and younger students in descriptive analyses. In multivariable analysis, enrollment in private universities (OR = 1.87, 95% CI: 1.68-2.08), studying in scientific/engineering/technical (OR = 1.48, 95% CI: 1.30-1.68) or administrative/economic disciplines (OR = 1.31, 95% CI: 1.12-1.53), smoking (OR = 1.28, 95% CI: 1.12-1.47), and lack of access to university physical activity facilities (OR = 1.30, 95% CI: 1.16-1.47) were independently associated with higher odds of prolonged sedentary behavior. Older age was associated with lower odds (21-24 years: OR = 0.82; >/=25 years: OR = 0.64). CONCLUSION: Sedentary behavior is common among Yemeni university students, with certain groups at higher risk. These findings suggest that university-based strategies, such as improving access to physical activity facilities and promoting active lifestyles, may help reduce sedentary time and support student health. CI - (c) 2026. The Author(s). FAU - Al-Bawah, Naji AU - Al-Bawah N AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. Najialbawah@gmail.com. FAU - Baklola, Mohamed AU - Baklola M AUID- ORCID: 0000-0002-5572-0852 AD - Faculty of Medicine, Mansoura University Hospitals, Mansoura Universiry, Mansoura, Egypt. Mohamedbaklola2000@gmail.com. FAU - Arrabyee, Mohammed R AU - Arrabyee MR AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. mohammedarrabyee@gmail.com. FAU - Benmelouka, Amira Yasmine AU - Benmelouka AY AD - Faculty of Medicine, University of Algiers, Algiers, Algeria. FAU - Ramadan, Alaa AU - Ramadan A AD - Faculty of Medicine, South Valley University, Qena, Egypt. FAU - Mousa, Mariam Mohamed AU - Mousa MM AD - Faculty of Medicine, Menoufia University, Menoufia, Egypt. FAU - Al-Hemiary, Abdulrahman Saeed AU - Al-Hemiary AS AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. FAU - Homil, Osamah AU - Homil O AD - Faculty of Medicine, Emirates International University, Sana'a, Yemen. FAU - Aladimi, Mohammed AU - Aladimi M AD - Faculty of Medicine, Emirates International University, Sana'a, Yemen. FAU - Ban Rafuid, Husam Addin AU - Ban Rafuid HA AD - Faculty of Medicine, Emirates International University, Sana'a, Yemen. FAU - Al-Tashi, Ibrahim Isam AU - Al-Tashi II AD - Faculty of Medicine, Emirates International University, Sana'a, Yemen. FAU - Almagrami, Abdulrhman Abdo AU - Almagrami AA AD - Faculty of Medicine, Saba Region University, Marib, Yemen. FAU - Al-Shaaby, Abdulkareem AU - Al-Shaaby A AD - Faculty of Medicine, 21 September University, Sana'a, Yemen. FAU - Al-Hamzi, Abdullah AU - Al-Hamzi A AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. FAU - Al-Othrubi, Ziad Mohammed AU - Al-Othrubi ZM AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. FAU - Sharyan, Ehab AU - Sharyan E AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. FAU - Alaribi, Saif AU - Alaribi S AD - Faculty of Medicine, Emirates International University, Sana'a, Yemen. FAU - Ali, Ismail AU - Ali I AD - Faculty of Medicine, Jiblah University for Health and Medical Sciences, Ibb, Yemen. FAU - Arrabyee, Waseem B AU - Arrabyee WB AD - Faculty of Medicine, 21 September University, Sana'a, Yemen. FAU - Alharazi, Abdulmalik AU - Alharazi A AD - Faculty of Medicine, Emirates International University, Sana'a, Yemen. FAU - Al-Hendi, Mohammed AU - Al-Hendi M AD - Faculty of Medicine, Jiblah University for Health and Medical Sciences, Ibb, Yemen. FAU - Yahia, Fekri AU - Yahia F AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. FAU - Alwajeeh, Tarheeb AU - Alwajeeh T AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. FAU - Al-Jahmi, Amjed AU - Al-Jahmi A AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. FAU - Al-Eryani, Ahmed AU - Al-Eryani A AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. FAU - Qarih, Naqib AU - Qarih N AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. FAU - Rashed, Mujahed AU - Rashed M AD - Faculty of Medicine and Health Sciences, Amran University, Amran, Yemen. FAU - Youssef, Youssef T AU - Youssef YT AD - Faculty of Medicine, Mansoura University Hospitals, Mansoura Universiry, Mansoura, Egypt. FAU - Helal, Mohamed Basyouni AU - Helal MB AD - Faculty of Medicine, Menoufia University, Menoufia, Egypt. FAU - Abdelrahman, Mahitab Mohamed AU - Abdelrahman MM AD - Nursing administration and education department, College of Nursing, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia. FAU - Elsehrawy, Mohamed Gamal AU - Elsehrawy MG AD - Nursing administration and education department, College of Nursing, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260521 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - *Sedentary Behavior MH - Cross-Sectional Studies MH - Universities MH - *Students/statistics & numerical data/psychology MH - Young Adult MH - Yemen/epidemiology MH - Adolescent MH - Male MH - Adult MH - Prevalence MH - Surveys and Questionnaires PMC - PMC13383506 OTO - NOTNLM OT - Lifestyle factors OT - Physical inactivity OT - Public health OT - Sedentary behavior OT - University students OT - Yemen OT - Young adults COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Institutional Review Board (IRB) of Amran University prior to study initiation (protocol code: 825). The study was conducted in accordance with established ethical standards for human research and adhered to the principles of the Declaration of Helsinki. Participation was voluntary, and participants were informed about the study objectives, the confidentiality and anonymity of their responses, and their right to withdraw at any time without consequences. Electronic informed consent was obtained from all participants before completing the questionnaire. No personally identifiable information was collected. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/22 06:32 MHDA- 2026/07/20 00:37 PMCR- 2026/05/21 CRDT- 2026/05/22 00:27 PHST- 2026/03/18 00:00 [received] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/07/20 00:37 [medline] PHST- 2026/05/22 06:32 [pubmed] PHST- 2026/05/22 00:27 [entrez] PHST- 2026/05/21 00:00 [pmc-release] AID - 10.1186/s12889-026-27767-6 [pii] AID - 27767 [pii] AID - 10.1186/s12889-026-27767-6 [doi] PST - epublish SO - BMC Public Health. 2026 May 21;26(1):2182. doi: 10.1186/s12889-026-27767-6. PMID- 42168987 OWN - NLM STAT- MEDLINE DCOM- 20260805 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 May 21 TI - Prevalence of overweight and obesity and their associations with lifestyle habits among late adolescents in the Northern Border Region of Saudi Arabia: a cross‑sectional study. LID - 10.1186/s12889-026-27537-4 [doi] LID - 2272 AB - BACKGROUND: Adolescent obesity is a growing public health problem worldwide, and Saudi data show a high and rising burden of excess weight among youth with marked regional and gender disparities. Late adolescence is a critical window in which lifestyle behaviours consolidate and track into adulthood. AIM: To estimate the prevalence of overweight and obesity (primary outcome) and to examine their associations with lifestyle habits, including physical activity, sedentary behaviour, sleep, and dietary patterns (secondary outcomes), among late adolescents in the Northern Border Region of Saudi Arabia. METHODS: A cross‑sectional study was conducted among 352 late adolescents (18-21 years) enrolled in high schools and universities in the Northern Border Region, selected from a finite population of 51,461 using Cochran's formula. Body mass index (BMI) was calculated from self‑reported weight/height, and classified according to WHO cut‑offs. Lifestyle habits were assessed using the validated Arab Teens Lifestyle (ATLS) questionnaire, which covers sociodemographic characteristics, physical activity, sedentary behaviour, sleep, and dietary habits. Associations between BMI categories and covariates were examined using Pearson's Chi-square tests and t‑tests/ANOVA, and multiple linear regression was used to identify factors independently associated with BMI. RESULTS: Among participants, 54.1% of those aged 18 years or younger were overweight, while 68.8% of those >18 years were obese (p =0.004). Males predominated in the overweight group (72.1%), whereas females accounted for most obese participants (59.7%; p <0.001). Lower family income (5,000 to less than 10,000 SAR) was associated with overweight (73.8%) and obesity (57.1%; p < 0.001). High screen time (>2 hours/day) was reported by 82.8% of overweight adolescents (p <0.001). High consumption of sugary and energy drinks was associated with higher BMI, whereas frequent fruit and vegetable intake was associated with significantly lower BMI (all p <0.001). In multivariable analysis, total physical activity was independently associated with lower BMI (B = -0.16, p<0.001), whereas a higher composite dietary score was modestly positively associated with BMI (B = 0.12, p<0.001). CONCLUSION: Overweight and obesity are common among late adolescents in the Saudi Northern Border Region and are closely linked to sociodemographic, behavioural, and dietary factors. Physical activity emerged as the key modifiable protective factor. In contrast, high screen time and frequent consumption of sugary drinks were associated with higher BMI, underscoring the need for targeted changes in food environments and opportunities for safe physical activity. CI - (c) 2026. The Author(s). FAU - Negm, Lobna Mohamed Mohamed Abu AU - Negm LMMA AUID- ORCID: 0000-0002-3824-1438 AD - Medical Surgical Nursing Department, Faculty of Nursing, Ain Shams University, Cairo, Egypt. dr.lubna.mohmmed@nursing.asu.edu.eg. AD - Emergency and Intensive Care Nursing Department, Faculty of Nursing, Northern Border University, Arar, Saudi Arabia. dr.lubna.mohmmed@nursing.asu.edu.eg. FAU - Aboelola, Taghreed Hussien AU - Aboelola TH AUID- ORCID: 0000-0002-7996-697X AD - Public Health Nursing Department, Faculty of Nursing, Northern Border University, Arar, Saudi Arabia. FAU - Mersal, Fathia Ahmed AU - Mersal FA AUID- ORCID: 0000-0002-6450-5097 AD - Public Health Nursing Department, Faculty of Nursing, Northern Border University, Arar, Saudi Arabia. FAU - Alanazi, Jawaher Mohammed AU - Alanazi JM AUID- ORCID: 0009-0009-8807-7785 AD - Bone marrow and stem cells Transplantation Department, Comprehensive Cancer Center, Second Health Cluster, King Fahad Medical City, Riyadh, Saudi Arabia. FAU - Alanazi, Rawan Khalid AU - Alanazi RK AUID- ORCID: 0009-0006-6874-7049 AD - Faculty of Nursing, Northern Border University, Arar, Saudi Arabia. FAU - Al-Shammari, Reem Ali Jalawi AU - Al-Shammari RAJ AUID- ORCID: 0009-0008-6736-0680 AD - Maternity and Pediatric Hospital, Northern Borders Health Cluster, Rafha, Saudi Arabia. FAU - Alanazi, Raghad Saad AU - Alanazi RS AUID- ORCID: 0009-0008-7373-8395 AD - Faculty of Nursing, Northern Border University, Arar, Saudi Arabia. FAU - Fawzy, Manal S AU - Fawzy MS AUID- ORCID: 0000-0003-1252-8403 AD - Center for Health Research, Northern Border University, Arar, Saudi Arabia. manal.darwish@nbu.edu.sa. FAU - Eltaib, Fatma Abdou Ahmed AU - Eltaib FAA AD - Medical Surgical Nursing Department, Faculty of Nursing, Ain Shams University, Cairo, Egypt. AD - Medical Surgical Nursing, Faculty of Nursing, Northern Border University, Arar, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260521 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Adolescent MH - Cross-Sectional Studies MH - Male MH - Female MH - *Life Style MH - Young Adult MH - Prevalence MH - *Overweight/epidemiology MH - Body Mass Index MH - Sedentary Behavior MH - *Pediatric Obesity/epidemiology MH - Exercise MH - Feeding Behavior PMC - PMC13440119 OTO - NOTNLM OT - Arab Teens Lifestyle Study (ATLS), Northern Border Region OT - Late-adolescent OT - Lifestyle habits OT - Obesity OT - Saudi Arabia COIS- Declarations. Ethics approval and consent to participate: "The study was approved by the Local Committee of Bioethics at Northern Border University, Saudi Arabia (approval number: 121/24/H). Informed consent was obtained from all participants before taking part." Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/22 06:32 MHDA- 2026/08/05 06:41 PMCR- 2026/05/21 CRDT- 2026/05/22 00:26 PHST- 2025/12/21 00:00 [received] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/08/05 06:41 [medline] PHST- 2026/05/22 06:32 [pubmed] PHST- 2026/05/22 00:26 [entrez] PHST- 2026/05/21 00:00 [pmc-release] AID - 10.1186/s12889-026-27537-4 [pii] AID - 27537 [pii] AID - 10.1186/s12889-026-27537-4 [doi] PST - epublish SO - BMC Public Health. 2026 May 21;26(1):2272. doi: 10.1186/s12889-026-27537-4. PMID- 42167647 OWN - NLM STAT- Publisher LR - 20261020 IS - 1527-5418 (Electronic) IS - 0890-8567 (Linking) DP - 2026 May 20 TI - Optimizing Pharmacological Treatment in Children and Adolescents With Major Depressive Disorder: An Individual Participant Data Analysis. LID - S0890-8567(26)00233-9 [pii] LID - 10.1016/j.jaac.2026.05.010 [doi] AB - OBJECTIVE: The specific influence of individual characteristics on antidepressant efficacy and tolerability in pediatric major depressive disorder (MDD) remains unclear. This study aimed to characterize subgroup-specific treatment efficacy and to establish a preliminary scientific foundation for precision psychiatry in pediatric MDD management based on available data. METHOD: An individual participant data (IPD) analysis of double-blind randomized trials (RCTs) was conducted to compare antidepressants with placebo for the acute treatment of MDD in children and adolescents. Subgroup analyses identified treatment outcome differences by participant characteristics, with mixed-effects models used to examine effect modifiers. Primary outcomes were efficacy (depressive symptom change, mean difference [MD]) and tolerability (adverse event-related withdrawals, odds ratio [OR]). Secondary outcomes included deterioration and suicide-related outcomes. The protocol is registered with PROSPERO (CRD42016051657). RESULTS: IPD from 10 of 40 eligible RCTs (2,584 participants) on 5 antidepressants (fluoxetine [n = 475], imipramine [n = 95], paroxetine [n = 413], desvenlafaxine [n = 358], duloxetine [n = 341]), and placebo [n = 902] were analyzed. Most trials had "some concerns" for risk of bias. There was also substantial missing data for key covariates (eg, 53% for family history of psychiatric disorders). Inconsistencies in the reporting and collection of suicide-related outcomes (ideation and attempts) limited our analyses. In the individual participant meta-analysis, subgroup analysis showed that fluoxetine was the only agent significantly more effective than placebo (MD = -2.43). Imipramine (OR = 5.43) and paroxetine (OR = 1.85) showed poor tolerability. In terms of subgroup analyses based on individual participant characteristics, fluoxetine demonstrated superior efficacy in children, female participants, White participants, healthy weight participants, and those with severe symptoms (MDs = -3.90 to -2.60). Fluoxetine also showed less deterioration in female participants (OR = 0.55, 95% CI = 0.37 to 0.83). No significant differences in suicide-related outcomes were observed across subgroups based on individual characteristics. CONCLUSION: These provide a preliminary understanding of one possible precision medicine framework for pediatric MDD, indicating that individual characteristics (age, sex, ethnicity, body mass index [BMI], symptom severity, family history) may influence treatment outcomes. Exploratory subgroup analyses suggest fluoxetine's efficacy may be more pronounced in certain populations: children, female participants, White individuals, healthy weight participants, and those with severe symptoms. These findings should be interpreted with caution as IPD was only available from a quarter of eligible clinical trials, introducing data availability bias. These findings also require further validation in more diverse cohorts. Universal suicide-related outcome assessment across all subgroups (regardless of individual characteristics) remains essential. Broader data sharing is needed to improve representativeness in future IPD analyses. STUDY REGISTRATION INFORMATION: Comparative efficacy and tolerability of new-generation antidepressants for major depressive disorder in children and adolescents: protocol of an individual patient data meta-analysis; https://www.crd.york.ac.uk/PROSPERO/view/CRD42016051657. CI - Copyright (c) 2026 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved. FAU - Xiang, Yajie AU - Xiang Y AD - Yongchuan Hospital of Chongqing Medical University, Chongqing, China; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Cuijpers, Pim AU - Cuijpers P AD - Amsterdam Public Health research institute, Vrije Universiteit Amsterdam, the Netherlands. FAU - Li, Wei AU - Li W AD - The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Chengdu Third People's Hospital, Chengdu, China. FAU - Bao, Qingyan AU - Bao Q AD - The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Weisz, John R AU - Weisz JR AD - Harvard University, Cambridge, Massachusetts. FAU - Shi, Jie AU - Shi J AD - National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, China. FAU - Du, Xiaoyan AU - Du X AD - Yongchuan Hospital of Chongqing Medical University, Chongqing, China; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Yang, Hongmei AU - Yang H AD - The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Barth, Jurgen AU - Barth J AD - Institute for Complementary and Integrative Medicine, University Hospital Zurich and University of Zurich, Zurich, Switzerland. FAU - Coghill, David AU - Coghill D AD - Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia. FAU - Leucht, Stefan AU - Leucht S AD - School of Medicine and Health, Technische Universitat Munchen, Munich, Germany. FAU - Hazell, Philip AU - Hazell P AD - Discipline of Psychiatry, Sydney Medical School, Concord West, New South Wales, Australia. FAU - Cohen, David AU - Cohen D AD - Hopital Pitie-Salpetriere, Institut des Systemes Intelligents et Robotiques, Sorbonne Universite, Paris, France. FAU - Ravindran, Arun V AU - Ravindran AV AD - Campbell Family Mental Health Research Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada. FAU - Michael, Kurt D AU - Michael KD AD - The Jed Foundation, New York, New York; Huntsman Mental Health Institute, University of Utah, Child Psychiatry, Salt Lake City, Utah. FAU - Teng, Teng AU - Teng T AD - The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Zhou, Xinyu AU - Zhou X AD - The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Lu, Lin AU - Lu L AD - National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, China; Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China; Institute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China. FAU - Xie, Peng AU - Xie P AD - The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: xiepeng@cqmu.edu.cn. LA - eng PT - Journal Article DEP - 20260520 PL - United States TA - J Am Acad Child Adolesc Psychiatry JT - Journal of the American Academy of Child and Adolescent Psychiatry JID - 8704565 SB - IM EIN - J Am Acad Child Adolesc Psychiatry. 2026 Jul 24:S0890-8567(26)01538-8. doi: 10.1016/j.jaac.2026.07.1226. PMID: 42498220 EIN - J Am Acad Child Adolesc Psychiatry. 2026 Oct 20:S0890-8567(26)02197-0. doi: 10.1016/j.jaac.2026.10.014. PMID: 42901237 OTO - NOTNLM OT - antidepressant OT - child and adolescent OT - depression OT - individual participant data EDAT- 2026/05/22 00:33 MHDA- 2026/05/22 00:33 CRDT- 2026/05/21 19:40 PHST- 2025/10/23 00:00 [received] PHST- 2026/04/05 00:00 [revised] PHST- 2026/05/13 00:00 [accepted] PHST- 2026/05/22 00:33 [pubmed] PHST- 2026/05/22 00:33 [medline] PHST- 2026/05/21 19:40 [entrez] AID - S0890-8567(26)00233-9 [pii] AID - 10.1016/j.jaac.2026.05.010 [doi] PST - aheadofprint SO - J Am Acad Child Adolesc Psychiatry. 2026 May 20:S0890-8567(26)00233-9. doi: 10.1016/j.jaac.2026.05.010. PMID- 42166361 OWN - NLM STAT- MEDLINE DCOM- 20260914 LR - 20260914 IS - 2769-707X (Electronic) IS - 2769-7061 (Linking) VI - 45 IP - 7 DP - 2026 Sep-Oct TI - Cell Membrane Capacitance and Characteristic Frequency Among Youth and Adults: Reference Data From NHANES 1999-2000. PG - 622-631 LID - 10.1080/27697061.2026.2665157 [doi] AB - OBJECTIVE: Cell membrane capacitance (Cm) and characteristic frequency (fc) are two lesser-studied bioelectrical characteristics that may provide valuable insight into cell membrane integrity, yet reference data on these variables are scant. This study aimed to report normative data for Cm and fc among youth and adult populations. Secondary aims were to compare Cm and fc between subgroups, compare 50 kHz to fc, and explore relationships between fc and fat-free mass (FFM). METHOD: A secondary analysis was performed using data from the 1999-2000 U.S. National Health and Nutrition Examination Survey data set, including bioelectrical impedance spectroscopy data from male and female youth (8-17 years) and adults (18-49 years) to report reference data. Mann-Whitney U comparisons between sex and age subgroups and one-sample Wilcoxon rank test comparing fc to the common 50-kHz approximation were also conducted. RESULTS: Cm and fc ranged among youth (Cm = 0.43-4.57 nF; fc = 20.0-95.0 kHz) and adults (Cm = 0.65-4.68 nF; fc = 26.0-89.0 kHz). The youth group had significantly lower Cm (p < .001) and higher fc (p < .001) than the adults, while males had significantly higher Cm (p < .001) and lower fc (p < .001) than females. Compared to 50 kHz, fc was 9.0 kHz higher in youth (p < .001) and 7.0 kHz lower in adults (p < .001), while being 4.0 kHz lower with all ages combined (p < .001). CONCLUSIONS: Cm appears to mirror expected FFM differences between youths and adults and between males and females, while fc appears to have a largely inverse relationship with FFM, although the relationship is quadratic with a nadir near 35 to 40 kHz in adulthood. Cm and fc may have potential as noninvasive and clinically practical indicators of cell membrane functionality and maturation, although more research is needed to examine longitudinal validity of these measures alongside direct cellular observation. FAU - Lafontant, Kworweinski AU - Lafontant K AUID- ORCID: 0000-0002-8756-9827 AD - Physiology of Work and Exercise Response (POWER) Lab, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA. FAU - Robinson, Marcus AU - Robinson M AUID- ORCID: 0009-0008-3817-8695 AD - Physiology of Work and Exercise Response (POWER) Lab, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA. FAU - Sterner, Danielle A AU - Sterner DA AUID- ORCID: 0009-0007-4701-4070 AD - Physiology of Work and Exercise Response (POWER) Lab, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA. FAU - Lebron, Modesto A AU - Lebron MA AUID- ORCID: 0000-0002-2636-4318 AD - Physiology of Work and Exercise Response (POWER) Lab, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA. AD - Department of Kinesiology, Mississippi State University, Starkville, Mississippi, USA. FAU - Antonio, Brandi AU - Antonio B AUID- ORCID: 0009-0009-1083-8281 AD - Physiology of Work and Exercise Response (POWER) Lab, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA. FAU - Livingston, Jack AU - Livingston J AUID- ORCID: 0009-0009-0356-9749 AD - Physiology of Work and Exercise Response (POWER) Lab, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA. FAU - Smith, Sofea AU - Smith S AUID- ORCID: 0009-0005-7673-4697 AD - Physiology of Work and Exercise Response (POWER) Lab, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA. FAU - Rossi, Carlo AU - Rossi C AUID- ORCID: 0000-0002-1208-1034 AD - Physiology of Work and Exercise Response (POWER) Lab, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA. AD - Sport and Exercise Research Unit, Department of Psychology, Educational Science, and Human Movement, University of Palermo, Palermo, Italy. FAU - Stout, Jeffrey R AU - Stout JR AUID- ORCID: 0000-0001-6114-1649 AD - Physiology of Work and Exercise Response (POWER) Lab, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA. FAU - Fukuda, David H AU - Fukuda DH AUID- ORCID: 0000-0002-4299-7764 AD - Physiology of Work and Exercise Response (POWER) Lab, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA. LA - eng PT - Journal Article DEP - 20260521 PL - United States TA - J Am Nutr Assoc JT - Journal of the American Nutrition Association JID - 9918300687506676 SB - IM MH - Humans MH - Female MH - Male MH - Nutrition Surveys MH - Adolescent MH - Electric Impedance MH - Adult MH - Reference Values MH - Child MH - *Cell Membrane/physiology MH - Middle Aged MH - Young Adult MH - *Body Composition MH - *Electric Capacitance MH - United States OTO - NOTNLM OT - Bioimpedance OT - bioelectrical impedance analysis OT - bioelectrical impedance spectroscopy OT - life-span OT - normative EDAT- 2026/05/21 18:32 MHDA- 2026/09/14 17:40 CRDT- 2026/05/21 13:03 PHST- 2026/09/14 17:40 [medline] PHST- 2026/05/21 18:32 [pubmed] PHST- 2026/05/21 13:03 [entrez] AID - 10.1080/27697061.2026.2665157 [doi] PST - ppublish SO - J Am Nutr Assoc. 2026 Sep-Oct;45(7):622-631. doi: 10.1080/27697061.2026.2665157. Epub 2026 May 21. PMID- 42165722 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 0971-5916 (Print) IS - 0971-5916 (Linking) VI - 163 IP - 4 DP - 2026 Apr TI - Machine learning-based prediction of inflammation adjusted iron deficiency anaemia using blood cell indices. PG - 469-476 LID - 10.25259/IJMR_1500_2025 [pii] AB - Background and objectives Diagnosis of iron deficiency anaemia (IDA), where both anaemia and iron deficiency coexist, is essential to improve the precision of iron treatment. The serum ferritin, a marker of iron deficiency, is an acute phase protein, requires adjustment for inflammation prior to using it for diagnosis of IDA. The blood cell indices (referred as complete blood counts, CBC) help in identifying the underlying cause of anaemia and presence of inflammation, both of which could be utilised for differential diagnosis of IDA. We conducted this study to evaluate machine learning (ML) models for predicting inflammation-adjusted IDA from CBC data. Methods We utilised CBC data from National Health and Nutrition Examination Survey (NHANES 2017-2023) of women of reproductive age (15-50 yr age, n=3604) and evaluated the performance of ML models to predict the inflammation adjusted IDA, in terms of sensitivity and specificity. We validated the performance of the optimised random forest (RF)- ML model, on women of reproductive age data set from India (n=381) in predicting the IDA, and haemoglobin response to iron treatment. Results The optimised RF model predicted the inflammation adjusted IDA, solely based on CBC, with sensitivity and specificity of approximately 95% either on the test or validation data. In those predicted to have IDA (2.3+/-1.6 g/dL, n=283), the haemoglobin increments due to iron therapy was markedly higher compared to those predicted to have non-IDA (0.31+/-0.67 g/dL, n=98). Interpretation and conclusions These findings suggest that it is possible to predict inflammation adjusted IDA with high sensitivity and specificity with ML models using CBC data. FAU - Palika, Ravindranadh AU - Palika R AD - ICMR-National Institute of Nutrition, Hyderabad, Telangana, India. FAU - Dasi, Teena AU - Dasi T AD - ICMR-National Institute of Nutrition, Hyderabad, Telangana, India. FAU - Parasannanavar, Devraj J AU - Parasannanavar DJ AD - ICMR-National Institute of Nutrition, Hyderabad, Telangana, India. FAU - Banjara, Santosh Kumar AU - Banjara SK AD - ICMR-National Institute of Nutrition, Hyderabad, Telangana, India. FAU - Kulkarni, Bharati AU - Kulkarni B AD - ICMR-National Institute of Nutrition, Hyderabad, Telangana, India. FAU - Pullakhandam, Raghu AU - Pullakhandam R AD - ICMR-National Institute of Nutrition, Hyderabad, Telangana, India. LA - eng PT - Journal Article PL - United States TA - Indian J Med Res JT - The Indian journal of medical research JID - 0374701 RN - 9007-73-2 (Ferritins) RN - E1UOL152H7 (Iron) SB - IM MH - Humans MH - Female MH - *Anemia, Iron-Deficiency/blood/diagnosis/epidemiology/pathology MH - *Machine Learning MH - *Inflammation/blood/pathology/diagnosis MH - Adult MH - Middle Aged MH - Ferritins/blood MH - Blood Cell Count MH - Adolescent MH - Random Forest MH - Iron/blood MH - Young Adult MH - Predictive Learning Models MH - India/epidemiology MH - Nutrition Surveys MH - Prediction Algorithms MH - Classification Algorithms PMC - PMC13224302 OTO - NOTNLM OT - Anaemia OT - Blood cell indices OT - Complete blood counts OT - Iron deficiency OT - Machine learning OT - Random forest OT - Serum ferritin OT - Women of reproductive age COIS- None. EDAT- 2026/05/21 12:36 MHDA- 2026/05/21 12:37 PMCR- 2026/04/01 CRDT- 2026/05/21 10:04 PHST- 2025/06/11 00:00 [received] PHST- 2025/12/21 00:00 [accepted] PHST- 2026/05/21 12:37 [medline] PHST- 2026/05/21 12:36 [pubmed] PHST- 2026/05/21 10:04 [entrez] PHST- 2026/04/01 00:00 [pmc-release] AID - 10.25259/IJMR_1500_2025 [pii] AID - 10.25259/IJMR_1500_2025 [doi] PST - ppublish SO - Indian J Med Res. 2026 Apr;163(4):469-476. doi: 10.25259/IJMR_1500_2025. PMID- 42165382 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260901 IS - 1099-0496 (Electronic) IS - 1099-0496 (Linking) VI - 61 IP - 5 DP - 2026 May TI - Reliability of Home Sleep Apnea Test as a Diagnostic Modality in Children With Obstructive Sleep Apnea- a Systematic Review. PG - e71674 LID - 10.1002/ppul.71674 [doi] AB - BACKGROUND: The incidence of pediatric sleep disordered breathing has increased in the last decade because of many factors, such as childhood obesity, metabolic syndrome, and access to better diagnostic methods. OSA peaks between 2 and 8 years in children. Early diagnosis is recommended to prevent long-term complications. While PSG is the gold standard for diagnosis, it may not be feasible in certain circumstances; hence, HSAT is now being increasingly used to screen and diagnose OSA. METHODS: This review was conducted using the methodology in the "Cochrane handbook on systematic reviews". PRISMA flowchart was used to report the results. The risk of bias assessment was done using the "Cochrane handbook for systematic review reviews tool for Interventional studies". All studies were analysed using the Joanna Briggs Institute's critical appraisal tool. RESULTS: A total of nine studies were included in this review. Of these, only three studies employed simultaneous HSAT and PSG testing to evaluate the validity of HSAT indices. In one of the largest studies comparing HSAT with PSG, the mean AHI observed was 2.5 +/- 3 for HSAT and 2.7 +/- 2.9 for PSG (p > 0.05), indicating that the diagnostic yields of both methods were nearly equivalent. In studies utilizing HSAT alone, the mean apnea-hypopnea index (AHI) ranged from 0.8 to 10.3 events per hour in healthy children, compared to 2.2 to 13 events per hour in children with Down syndrome. CONCLUSIONS: Diagnosing sleep disordered breathing in children can be challenging in a laboratory setting. HSAT is cost-effective and better tolerated in the younger population compared to PSG. It is a reliable alternative to PSG when used with multiple channels, including EEG and capnography. CI - (c) 2026 Wiley Periodicals LLC. FAU - Zafar, Adnan AU - Zafar A AUID- ORCID: 0000-0002-9886-6819 AD - Pediatric Pulmonology Department, John Hopkins Aramco Healthcare, Dhahran, Saudi Arabia. FAU - Roman, Umme AU - Roman U AD - Karachi Medical and Dental College, Karachi, Pakistan. FAU - Haseeb, Abdul AU - Haseeb A AD - Karachi Medical and Dental College, Karachi, Pakistan. FAU - Akhtar, Taslim AU - Akhtar T AD - Pediatric Department, John Hopkins Aramco Healthcare, Dhahran, Saudi Arabia. LA - eng PT - Journal Article PT - Systematic Review PL - United States TA - Pediatr Pulmonol JT - Pediatric pulmonology JID - 8510590 SB - IM MH - Humans MH - *Sleep Apnea, Obstructive/diagnosis MH - Child MH - Polysomnography/methods MH - Reproducibility of Results MH - Child, Preschool OTO - NOTNLM OT - HSAT (home sleep apnea test) OT - PSG OT - apnea hypopnea index) OT - pediatric sleep EDAT- 2026/05/21 12:37 MHDA- 2026/05/21 12:38 CRDT- 2026/05/21 07:52 PHST- 2026/05/05 00:00 [revised] PHST- 2025/11/22 00:00 [received] PHST- 2026/05/13 00:00 [accepted] PHST- 2026/05/21 12:38 [medline] PHST- 2026/05/21 12:37 [pubmed] PHST- 2026/05/21 07:52 [entrez] AID - 10.1002/ppul.71674 [doi] PST - ppublish SO - Pediatr Pulmonol. 2026 May;61(5):e71674. doi: 10.1002/ppul.71674. PMID- 42164096 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260521 LR - 20260813 IS - 2772-6533 (Electronic) IS - 2772-6533 (Linking) VI - 8 DP - 2026 Jun TI - Development and validation of risk factors lifestyle disorders scale (RFLDS): A cohort study. PG - 100307 LID - 10.1016/j.dialog.2026.100307 [doi] LID - 100307 AB - BACKGROUND: Adolescents are presumed to be healthy, but being a vulnerable group they are threatened with morbidities. Management of risk factors which concern and affect lifestyle disorders must begin during adolescence. The aim of study is to develop and validate a scale to assess risk factors leading to lifestyle disorders in quick and concise manner. METHODS: Risk Factor Lifestyle Disorders Scale (RFLDS) has been developed to identify risk factors of lifestyle disorders on low, borderline and high risk zones based on scientific exhaustive review of literature and expert consensus. Cross-sectional baseline data from planned cohort of 1000 school-based adolescents aged between 16 and 18 years from Tricity- Chandigarh, Panchkula and Mohali (India) was carried out. Three phase validation of content, construct and criterion validity has been conducted to develop the scale. Analyses were done through Item Total Reliability, Exploratory Factor Analysis, Cronbach's Alpha and Pearsons Correlation. FINDINGS: Results layout a structure of developed and validated scale. KMO measure of 0.720, Bartlett test of p < 0.0001, leading to seven factors consisting of 19 items of 64.75% variance and Cronbach's alpha of 0.68 was observed. Final scale consists of seven factors that emerged out of 19 identified items namely Socio-Economic Criteria (SEC), Nutritional Status (NS), Body Composition (BC), Low Risk Factor Foods (LRF), High Risk Factor Foods (HRF), Mental Health and Family and Personal History (MHFPH) and Sleep and Physical Activity (SPA). INTERPRETATION: Lifestyle disorders lead to deterioration in quality of life. Comprehensive RFLDS- Risk Factors Lifestyle Disorders Scale, validated in adolescents only, may be used for easy and quick assessment, addressal and prevention of lifestyle disorders. It may also be used as a screening tool in institutes, clinical and public health care systems to improve overall well-being, aligning with WHO's Sustainable Development Goal 3.4. CI - (c) 2026 The Authors. Published by Elsevier Inc. FAU - Singh, Kalyani AU - Singh K AD - Department of Foods and Nutrition, Government Home Science College, Chandigarh, India. FAU - Pradhan, Ritu AU - Pradhan R AD - Department of Foods and Nutrition, Government Home Science College, Chandigarh, India. LA - eng PT - Journal Article DEP - 20260503 PL - United States TA - Dialogues Health JT - Dialogues in health JID - 9918506184906676 PMC - PMC13186033 OTO - NOTNLM OT - Adolescents OT - Health OT - Lifestyle OT - Lifestyle disorders OT - Scale OT - Sustainable development goal 3.4 OT - WHO COIS- The authors have no declared conflicts of interest. EDAT- 2026/05/21 06:33 MHDA- 2026/05/21 06:34 PMCR- 2026/05/03 CRDT- 2026/05/21 04:37 PHST- 2025/04/30 00:00 [received] PHST- 2026/05/01 00:00 [revised] PHST- 2026/05/01 00:00 [accepted] PHST- 2026/05/21 06:34 [medline] PHST- 2026/05/21 06:33 [pubmed] PHST- 2026/05/21 04:37 [entrez] PHST- 2026/05/03 00:00 [pmc-release] AID - S2772-6533(26)00032-8 [pii] AID - 100307 [pii] AID - 10.1016/j.dialog.2026.100307 [doi] PST - epublish SO - Dialogues Health. 2026 May 3;8:100307. doi: 10.1016/j.dialog.2026.100307. eCollection 2026 Jun. PMID- 42163956 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260521 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Development and validation of an explainable machine learning-based risk prediction model for obesity in Chinese children and adolescents: a population-based study. PG - 1816724 LID - 10.3389/fnut.2026.1816724 [doi] LID - 1816724 AB - BACKGROUND: Childhood obesity represents a significant global public health challenge. Accurate and rapid prediction models for identifying obesity risk in children and adolescents are essential for facilitating early prevention and enabling timely interventions. However, interpretable and user-friendly obesity risk prediction models based on nationally representative data remain limited. This study aimed to develop and validate a model to predict current obesity risk among children and adolescents in China. METHODS: The models were developed using cross-sectional data from the 2017-2018 Physical Activity and Fitness in China-The Youth Study (PAFCTYS; n = 35,016) and were temporally validated with 2020 data (n = 3,495). Candidate predictors (n = 38), primarily encompassing physical activity, sedentary behavior, and sociodemographic variables, were measured concurrently with the outcome. The participants included individuals from 31 administrative regions across China. Features were identified using the Least Absolute Shrinkage and Selection Operator (LASSO) with recursive feature elimination (RFE), and predictive models were developed using eight different machine learning algorithms. The model's performance was evaluated using metrics such as AUC, sensitivity, specificity, Matthews Correlation Coefficient (MCC), and Brier score. The model was interpreted using the SHapley Additive exPlanation (SHAP) method. RESULTS: The random forest (RF) model outperformed all other models, achieving an AUC of 1.000 on the training set and 0.946 on the testing set. It also maintained good discriminative performance on the temporal validation dataset, with an AUC of 0.810. The RF model also shows the highest accuracy, specificity, and MCC, and the lowest Brier score. SHAP analysis indicates that parental BMI, using mobile electronic devices on weekdays, MVPA (moderate-to-vigorous physical activity), watching TV on weekdays, and sex are the top 5 most important features in the obesity risk prediction model. A web-based risk calculator based on the RF model has been successfully deployed. CONCLUSION: Using a large, nationally representative sample and readily available variables, we successfully developed and validated an obesity risk prediction model for Chinese children and adolescents using explainable machine learning techniques. The model can quickly and accurately assess an individual's current obesity risk, enabling healthcare agencies, schools, and parents to conduct large-scale obesity risk screening. CI - Copyright (c) 2026 Chen, Zhu and Chen. FAU - Chen, Zekai AU - Chen Z AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Zhu, Lin AU - Zhu L AD - School of Sport and Health, Guangzhou Sport University, Guangzhou, China. AD - Innovative Research Center for Sports Science in the Guangdong-Hong Kong-Macao Greater Bay Area, Guangzhou Sport University, Guangzhou, China. FAU - Chen, Peijie AU - Chen P AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. LA - eng PT - Journal Article DEP - 20260505 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13183532 OTO - NOTNLM OT - SHAP OT - children and adolescents OT - machine learning OT - obesity OT - prediction model COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/21 06:32 MHDA- 2026/05/21 06:33 PMCR- 2026/05/05 CRDT- 2026/05/21 04:35 PHST- 2026/02/24 00:00 [received] PHST- 2026/04/16 00:00 [revised] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/05/21 06:33 [medline] PHST- 2026/05/21 06:32 [pubmed] PHST- 2026/05/21 04:35 [entrez] PHST- 2026/05/05 00:00 [pmc-release] AID - 10.3389/fnut.2026.1816724 [doi] PST - epublish SO - Front Nutr. 2026 May 5;13:1816724. doi: 10.3389/fnut.2026.1816724. eCollection 2026. PMID- 42163318 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260714 LR - 20260813 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 14 IP - 1 DP - 2026 May 20 TI - Psychometric properties of the Night Eating Questionnaire (NEQ) in a clinical sample of Turkish adolescents. LID - 10.1186/s40337-026-01633-7 [doi] LID - 160 AB - BACKGROUND: This study aimed to examine the psychometric properties of the Turkish version of the Night Eating Questionnaire (NEQ) in an adolescent clinical sample. METHODS: The sample consisted of 267 adolescents aged 13-17 years (64.8% girls; mean age = 15.23 +/- 1.29 years) recruited from child and adolescent psychiatry outpatient clinics of two university hospitals in Turkiye. The NEQ, Eating Attitudes Test-26 (EAT-26), Revised Child Anxiety and Depression Scale - Child Version (RCADS-CV), and Sleep Quality Scale and Sleep Variables Questionnaire (SQS-SVQ) were administered. Exploratory factor analysis (EFA), confirmatory factor analysis (CFA), internal consistency, and convergent validity were examined. RESULTS: EFA identified a four-factor structure accounting for 62.39% of the total variance, consistent with the original factor solution. CFA supported the four-factor structure of the NEQ (CMIN/df = 1.606, RMSEA = 0.048, CFI = 0.964, TLI = 0.951), consisting of nocturnal ingestions, evening hyperphagia, morning anorexia, and mood/sleep disturbances. Internal consistency was acceptable for the total scale (Cronbach's alpha = 0.73). The NEQ demonstrated meaningful convergent validity through significant positive correlations with sleep quality, anxiety, depression, and disordered eating attitudes. Adolescents in the overweight group reported significantly higher NEQ total scores, particularly on the evening hyperphagia and mood/sleep disturbances subscales. Girls showed higher scores on morning anorexia and mood/sleep disturbances compared with boys. CONCLUSIONS: The Turkish NEQ demonstrated satisfactory psychometric properties in an adolescent clinical sample and appears to be a valid and reliable instrument for assessing night eating symptoms in Turkish adolescent clinical populations. CI - (c) 2026. The Author(s). FAU - Akinci, Mehmet Akif AU - Akinci MA AUID- ORCID: 0000-0002-6436-4394 AD - Department of Child and Adolescent Psychiatry, Ataturk University, Erzurum, Turkiye. akinci_mehmetakif@hotmail.com. FAU - Turan, Bahadir AU - Turan B AUID- ORCID: 0000-0003-1190-9589 AD - Department of Child and Adolescent Psychiatry, Karadeniz Technical University, Trabzon, Turkiye. AD - Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK. FAU - Bayindir, Kubra AU - Bayindir K AUID- ORCID: 0009-0004-6558-3515 AD - Department of Child and Adolescent Psychiatry, Ataturk University, Erzurum, Turkiye. FAU - Tuzcu, Furkan Can AU - Tuzcu FC AUID- ORCID: 0009-0008-3173-9429 AD - Department of Child and Adolescent Psychiatry, Karadeniz Technical University, Trabzon, Turkiye. FAU - Yildirim Demirdogen, Esen AU - Yildirim Demirdogen E AUID- ORCID: 0000-0002-2457-5832 AD - Department of Child and Adolescent Psychiatry, Ataturk University, Erzurum, Turkiye. FAU - Bozkurt, Abdullah AU - Bozkurt A AUID- ORCID: 0000-0002-8359-6131 AD - Department of Child and Adolescent Psychiatry, Ataturk University, Erzurum, Turkiye. LA - eng PT - Journal Article DEP - 20260520 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC13366900 OAB - Night Eating Syndrome (NES) is a condition in which people eat a large portion of their daily food late in the evening or during the night. To better understand and identify these behaviors, researchers often use questionnaires that measure the severity of night eating symptoms. In this study, we examined whether the Turkish version of the Night Eating Questionnaire (NEQ) is a reliable and useful tool for assessing night eating behaviors in adolescents. A total of 267 adolescents aged 13-17 years who were receiving care at child and adolescent psychiatry clinics participated in the study. They completed the NEQ along with several questionnaires about eating habits, sleep quality, and emotional well-being. Our findings showed that the Turkish NEQ works well in adolescents and can reliably measure different aspects of night eating, such as eating during the night, eating large amounts in the evening, loss of appetite in the morning, and sleep or mood-related difficulties. We also found that adolescents with higher body weight tended to report more severe night eating symptoms, and girls reported more sleep- and mood-related symptoms than boys. These results suggest that the NEQ can help clinicians identify night eating symptoms in adolescents and may support earlier recognition of eating-related problems in young people. OABL- eng OTO - NOTNLM OT - Adolescents OT - Night Eating Questionnaire OT - Night eating syndrome OT - Psychometric properties OT - Reliability OT - Validity COIS- Declarations. Ethics approval and consent to participate: Ethical committee approval was received from the Research Ethics Committee (REC) of Ataturk University (approval no: B.30.2.ATA.0.01.00/33; date: 21.02.2024). The study procedures were conducted in accordance with the principles of the Declaration of Helsinki. Written informed consent was obtained from all the participants and their parents. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/21 06:31 MHDA- 2026/05/21 06:32 PMCR- 2026/05/20 CRDT- 2026/05/21 01:10 PHST- 2026/03/13 00:00 [received] PHST- 2026/05/01 00:00 [accepted] PHST- 2026/05/21 06:32 [medline] PHST- 2026/05/21 06:31 [pubmed] PHST- 2026/05/21 01:10 [entrez] PHST- 2026/05/20 00:00 [pmc-release] AID - 10.1186/s40337-026-01633-7 [pii] AID - 1633 [pii] AID - 10.1186/s40337-026-01633-7 [doi] PST - epublish SO - J Eat Disord. 2026 May 20;14(1):160. doi: 10.1186/s40337-026-01633-7. PMID- 42162532 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261027 IS - 1573-2584 (Electronic) IS - 0301-1623 (Linking) VI - 58 IP - 11 DP - 2026 Nov TI - A study on the association between polycyclic aromatic hydrocarbon (PAH) exposure and kidney function indicators in adolescents: an integrated research combining statistical mediation analysis and network toxicology. PG - 5035-5059 LID - 10.1007/s11255-026-05194-1 [doi] AB - Polycyclic aromatic hydrocarbons (PAHs) are a class of environmental pollutants widely present in daily life. However, the association between mixed exposure to PAHs and kidney function remains unclear. This study aimed to analyze and evaluate the relationship between urinary PAH metabolite levels and multiple kidney function parameters in adolescents. Data were obtained from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2016. The cross-sectional associations between urinary PAH metabolites and kidney parameters were examined using multiple linear regression models. In addition, weighted quantile sum (WQS) regression and Bayesian kernel machine regression (BKMR) models were applied to evaluate the effects of mixed exposure to PAH metabolites on kidney function indicators. Statistical mediation analysis suggested that alkaline phosphatase (ALP) may play a potential mediating role. Furthermore, hypothesis-generating bioinformatics analyses were conducted using network toxicology and molecular docking approaches. A total of 1428 adolescents were included in this study. The results showed that all PAH metabolites were negatively associated with serum creatinine (Scr) (P(FDR) < 0.05) and positively associated with estimated glomerular filtration rate (eGFR) (P(FDR) < 0.05). Both WQS and BKMR models consistently indicated that mixed exposure to PAHs was positively associated with eGFR and negatively associated with Scr, urinary creatinine (Ucr), and serum uric acid (SUA). Bioinformatics analysis further identified five potential target proteins: albumin (ALB), epidermal growth factor receptor (EGFR), estrogen receptor 1 (ESR1), insulin-like growth factor 1 (IGF1), and peroxisome proliferator-activated receptor gamma (PPARG). Molecular docking was subsequently performed to predict the binding affinities between PAH metabolites and these candidate proteins. Our study identified an association between PAH exposure and kidney function in adolescents. These findings suggest that PAH exposure may be related to early alterations in kidney function among adolescents. However, the clinical significance and long-term health effects of these associations require further validation through longitudinal studies and mechanistic investigations. Nevertheless, our findings highlight concerns regarding the potential adverse effects of PAH metabolite exposure on adolescent kidney function and underscore its relevance for public health. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature B.V. FAU - Yao, Haijin AU - Yao H AD - Department of Pediatrics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China. FAU - Wang, Shuchang AU - Wang S AD - Department of Thyroid and Breast Surgery, The Harbin Second Hospital, Harbin, China. FAU - Zhang, Yuling AU - Zhang Y AD - Department of Pediatrics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China. 54517694@qq.com. LA - eng PT - Journal Article DEP - 20260521 PL - Netherlands TA - Int Urol Nephrol JT - International urology and nephrology JID - 0262521 RN - 0 (Polycyclic Aromatic Hydrocarbons) RN - AYI8EX34EU (Creatinine) RN - 0 (Environmental Pollutants) SB - IM MH - Humans MH - Adolescent MH - *Polycyclic Aromatic Hydrocarbons/urine/adverse effects/toxicity MH - Female MH - Male MH - Cross-Sectional Studies MH - *Glomerular Filtration Rate MH - *Environmental Exposure/adverse effects MH - Creatinine/blood MH - *Kidney/physiopathology/drug effects MH - *Environmental Pollutants/urine MH - Nutrition Surveys MH - Molecular Docking Simulation OTO - NOTNLM OT - Adolescents OT - Kidney function OT - Molecular docking OT - Network toxicology OT - Polycyclic aromatic hydrocarbons (PAHs) COIS- Declarations. Conflict of interest: The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this study. Ethical approval and consent to participate: This study analyzed publicly available data from the National Health and Nutrition Examination Survey (NHANES) in the United States. The NHANES study protocol was reviewed and approved by the Ethics Review Committee of the National Center for Health Statistics (NCHS). (NCHS Ethics Review Board approval protocol number: Continuation of Protocol #2005-06, Protocol #2011-17). All participants provided written informed consent. Since this study utilizes de-identified public data, does not involve direct interaction with original participants, and is limited to data analysis, it typically qualifies for ethical exemption under the widely accepted ethical guidelines of the Declaration of Helsinki. Clinical trial number: Not applicable. EDAT- 2026/05/21 05:33 MHDA- 2026/10/23 18:30 CRDT- 2026/05/20 23:42 PHST- 2026/01/21 00:00 [received] PHST- 2026/05/09 00:00 [accepted] PHST- 2026/10/23 18:30 [medline] PHST- 2026/05/21 05:33 [pubmed] PHST- 2026/05/20 23:42 [entrez] AID - 10.1007/s11255-026-05194-1 [pii] AID - 10.1007/s11255-026-05194-1 [doi] PST - ppublish SO - Int Urol Nephrol. 2026 Nov;58(11):5035-5059. doi: 10.1007/s11255-026-05194-1. Epub 2026 May 21. PMID- 42162020 OWN - NLM STAT- MEDLINE DCOM- 20260721 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 May 20 TI - Prevalence and severity of sleep-disordered breathing in individuals with Down syndrome using a portable home-based diagnostic device: a pilot study. LID - 10.1038/s41598-026-46328-w [doi] LID - 22905 AB - Down syndrome (DS) is associated with craniofacial abnormalities, muscular hypotonia, and upper airway obstruction, factors that increase the risk of obstructive sleep apnea (OSA). Despite the high likelihood of sleep-disordered breathing in this population, diagnostic access remains limited, especially in low-resource settings. This study aimed to determine the prevalence and severity of sleep-disordered breathing in adolescents and adults with DS. This cross-sectional study included adolescents and adults with DS who underwent home type IV polygraphy (Biologix) and completed validated questionnaires assessing OSA risk and excessive daytime sleepiness. Anthropometric data were collected, and correlations with respiratory parameters were analyzed. OSA was highly prevalent, affecting 93% of participants. Mild to moderate OSA predominated (80%). Respiratory events were frequently accompanied by oxygen desaturation, with marked nocturnal hypoxemia (mean minimum SpO(2): 82.4%). Sleep was inefficient and fragmented, with efficiency below 75% in most individuals. Neck circumference showed a significant correlation with nocturnal hypoxemia, whereas age and body weight did not. Subjective sleep questionnaires underestimated OSA severity compared with polygraphy. Sleep-disordered breathing appears to be highly prevalent and physiologically relevant in individuals with DS. Home type IV polygraphy proved feasible, well-accepted, and clinically informative for this population. These findings highlight the importance of accessible diagnostic strategies to improve early detection and management of OSA in individuals with DS. CI - (c) 2026. The Author(s). FAU - Matsui Yamaguchi, Miriam Yumi AU - Matsui Yamaguchi MY AD - Health Sciences Graduate Program, Santa Casa de Misericordia of Sao Paulo (FCMSCSP), Sao Paulo, Brazil. FAU - Silva Nunes, Carla Nobrega AU - Silva Nunes CN AD - Human Movement and Rehabilitation Graduate Program (PPGMHR), Evangelical University of Goias (UNIEVANGELICA), Goias, Brazil. FAU - de Freitas Junior, Wilson Rodrigues AU - de Freitas Junior WR AD - Health Sciences Graduate Program, Santa Casa de Misericordia of Sao Paulo (FCMSCSP), Sao Paulo, Brazil. FAU - Maia, Luciana Prado AU - Maia LP AD - Dentistry Graduate Program (PPGO), Evangelical University of Goias (UNIEVANGELICA), Goias, Brazil. FAU - Carvalho Andraus, Rodrigo A AU - Carvalho Andraus RA AD - Human Movement and Rehabilitation Graduate Program (PPGMHR), Evangelical University of Goias (UNIEVANGELICA), Goias, Brazil. FAU - Silva, Carlos Hassel Mendes AU - Silva CHM AD - Health Sciences Graduate Program, Santa Casa de Misericordia of Sao Paulo (FCMSCSP), Sao Paulo, Brazil. AD - Human Movement and Rehabilitation Graduate Program (PPGMHR), Evangelical University of Goias (UNIEVANGELICA), Goias, Brazil. FAU - Guerra Silva, Angela Silveira AU - Guerra Silva AS AD - Human Movement and Rehabilitation Graduate Program (PPGMHR), Evangelical University of Goias (UNIEVANGELICA), Goias, Brazil. FAU - Marianni, Stefani Vaz AU - Marianni SV AD - Human Movement and Rehabilitation Graduate Program (PPGMHR), Evangelical University of Goias (UNIEVANGELICA), Goias, Brazil. FAU - Pires Oliveira, Deise A A AU - Pires Oliveira DAA AD - Human Movement and Rehabilitation Graduate Program (PPGMHR), Evangelical University of Goias (UNIEVANGELICA), Goias, Brazil. FAU - Oliveira, Rodrigo Franco AU - Oliveira RF AD - Human Movement and Rehabilitation Graduate Program (PPGMHR), Evangelical University of Goias (UNIEVANGELICA), Goias, Brazil. FAU - Oliveira, Claudia Santos AU - Oliveira CS AD - Human Movement and Rehabilitation Graduate Program (PPGMHR), Evangelical University of Goias (UNIEVANGELICA), Goias, Brazil. FAU - Insalaco, Giuseppe AU - Insalaco G AD - Institute of Translational Pharmacology (IFT), National Research Council (CNR), Palermo, Italy. FAU - Gomes, Monica Fernandes AU - Gomes MF AD - Institute of Science and Technology (IST), Sao Paulo State University (UNESP), Sao Paulo, Brazil. FAU - Guedes, Orlando Aguirre AU - Guedes OA AD - Dentistry Graduate Program (PPGO), Evangelical University of Goias (UNIEVANGELICA), Goias, Brazil. FAU - Giannasi, Lilian Chrystiane AU - Giannasi LC AD - Health Sciences Graduate Program, Santa Casa de Misericordia of Sao Paulo (FCMSCSP), Sao Paulo, Brazil. FAU - de Oliveira, Luis Vicente Franco AU - de Oliveira LVF AD - Health Sciences Graduate Program, Santa Casa de Misericordia of Sao Paulo (FCMSCSP), Sao Paulo, Brazil. oliveira.lvf@gmail.com. AD - Human Movement and Rehabilitation Graduate Program (PPGMHR), Evangelical University of Goias (UNIEVANGELICA), Goias, Brazil. oliveira.lvf@gmail.com. AD - Dentistry Graduate Program (PPGO), Evangelical University of Goias (UNIEVANGELICA), Goias, Brazil. oliveira.lvf@gmail.com. LA - eng PT - Journal Article DEP - 20260520 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Down Syndrome/complications/physiopathology MH - Pilot Projects MH - *Sleep Apnea Syndromes/epidemiology/diagnosis/complications MH - Polysomnography/instrumentation MH - Female MH - Prevalence MH - Adolescent MH - Male MH - Adult MH - Cross-Sectional Studies MH - Severity of Illness Index MH - Surveys and Questionnaires MH - Young Adult MH - *Sleep Apnea, Obstructive/diagnosis/epidemiology PMC - PMC13389241 OTO - NOTNLM OT - Down syndrome OT - Polysomnography OT - Portable sleep monitor OT - Sleep apnea COIS- Declarations. Ethics approval and consent to participate: This study protocol was approved by the Ethics Committee for Human Research of the Institute of Science and Technology, UNESP, Sao Jose dos Campos (CAAE: 64173616.4.0000.0077). All the parents of the patients involved in the study provided the written Consent Form for participation in the research. Competing interests: The authors declare no competing interests. EDAT- 2026/05/21 05:33 MHDA- 2026/07/22 12:37 PMCR- 2026/05/20 CRDT- 2026/05/20 23:27 PHST- 2025/11/19 00:00 [received] PHST- 2026/03/25 00:00 [accepted] PHST- 2026/07/22 12:37 [medline] PHST- 2026/05/21 05:33 [pubmed] PHST- 2026/05/20 23:27 [entrez] PHST- 2026/05/20 00:00 [pmc-release] AID - 10.1038/s41598-026-46328-w [pii] AID - 46328 [pii] AID - 10.1038/s41598-026-46328-w [doi] PST - epublish SO - Sci Rep. 2026 May 20;16(1):22905. doi: 10.1038/s41598-026-46328-w. PMID- 42161366 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260717 IS - 1447-0594 (Electronic) IS - 1447-0594 (Linking) VI - 26 IP - 5 DP - 2026 May TI - Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis in the Oldest Old: Balancing Pancreatic Protection and Cardiorenal Safety: A Narrative Review. PG - e70548 LID - 10.1111/ggi.70548 [doi] AB - As the global population ages, the demand for endoscopic retrograde cholangiopancreatography (ERCP) in the "oldest old" (>/= 85 years) is steadily increasing. Despite their vulnerability, the existing evidence base for prophylaxis is heavily derived from younger populations, creating a significant extrapolation gap. Current guidelines for the prevention of Post-ERCP pancreatitis (PEP) advocate for universal measures-such as aggressive hydration and rectal nonsteroidal anti-inflammatory drugs-based on trials that frequently exclude frail patients with significant comorbidities. This perspective piece challenges the "one-size-fits-all" application of these protocols in the geriatric demographic, proposing a hypothetical clinical practice approach. We conducted a targeted review of peer-reviewed literature focusing on the pathophysiology of the aging pancreas and the safety of prophylactic interventions. Key findings reveal a "risk-outcome dissociation": while pancreatic senescence biologically lowers PEP incidence, frailty increases mortality when it occurs. Regarding fluid management, we propose a hypothesis-driven, restrictive hydration rate of 1.7 mL/kg/h without a bolus for patients with heart failure. This rate is physiologically grounded (adapted from the Holliday-Segar pediatric maintenance formula for the altered body composition of the elderly) to provide "enhanced maintenance" to cover fasting deficits while avoiding the volume surge (>/= 3 mL/kg/h) that precipitates pulmonary edema in non-compliant ventricles. Treating the elderly requires a paradigm shift to "Precision Geriatric Endoscopy", utilizing biomarker-driven triage and bedside frailty tools. Most critically, this proposed protocol represents a pathophysiological hypothesis and framework rather than established evidence. Future prospective randomized controlled trials are urgently needed to validate this approach. CI - (c) 2026 Japan Geriatrics Society. FAU - Takahashi, Koji AU - Takahashi K AUID- ORCID: 0000-0001-8134-8524 AD - Department of Gastroenterology, Eastern Chiba Medical Center, Togane, Japan. AD - Department of General Medical Science, Graduate School of Medicine, Chiba University, Chiba, Japan. FAU - Yamada, Nana AU - Yamada N AD - Department of Gastroenterology, Eastern Chiba Medical Center, Togane, Japan. AD - Department of General Medical Science, Graduate School of Medicine, Chiba University, Chiba, Japan. FAU - Iwanaga, Terunao AU - Iwanaga T AD - Department of Gastroenterology, Eastern Chiba Medical Center, Togane, Japan. AD - Department of General Medical Science, Graduate School of Medicine, Chiba University, Chiba, Japan. FAU - Sakuma, Takafumi AU - Sakuma T AD - Department of Gastroenterology, Eastern Chiba Medical Center, Togane, Japan. AD - Department of General Medical Science, Graduate School of Medicine, Chiba University, Chiba, Japan. FAU - Kamezaki, Hidehiro AU - Kamezaki H AUID- ORCID: 0000-0003-2238-9558 AD - Department of Gastroenterology, Eastern Chiba Medical Center, Togane, Japan. AD - Department of General Medical Science, Graduate School of Medicine, Chiba University, Chiba, Japan. LA - eng PT - Journal Article PT - Review PL - Japan TA - Geriatr Gerontol Int JT - Geriatrics & gerontology international JID - 101135738 SB - IM MH - Humans MH - *Cholangiopancreatography, Endoscopic Retrograde/adverse effects MH - *Pancreatitis/etiology/prevention & control/epidemiology MH - Aged, 80 and over MH - *Postoperative Complications/prevention & control OTO - NOTNLM OT - BNP OT - NSAIDs OT - POCUS OT - elderly OT - frailty OT - hydration OT - post-ERCP pancreatitis EDAT- 2026/05/21 05:33 MHDA- 2026/05/21 05:34 CRDT- 2026/05/20 20:02 PHST- 2026/05/03 00:00 [revised] PHST- 2026/03/24 00:00 [received] PHST- 2026/05/14 00:00 [accepted] PHST- 2026/05/21 05:34 [medline] PHST- 2026/05/21 05:33 [pubmed] PHST- 2026/05/20 20:02 [entrez] AID - 10.1111/ggi.70548 [doi] PST - ppublish SO - Geriatr Gerontol Int. 2026 May;26(5):e70548. doi: 10.1111/ggi.70548. PMID- 42161005 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260717 IS - 1873-7358 (Electronic) IS - 1471-0153 (Linking) VI - 61 DP - 2026 Apr TI - Validation and measurement invariance of the Intuitive Eating Scale-3 among Brazilian adolescents. PG - 102093 LID - S1471-0153(26)00026-7 [pii] LID - 10.1016/j.eatbeh.2026.102093 [doi] AB - Intuitive eating is an evidence-based, non-diet approach to nutrition that heals individuals' relationship with food by listening to internal body cues rather than external rules. The Intuitive Eating Scale is a widely used measure that has been validated across diverse cultural contexts and among individuals of different sociocultural backgrounds. However, its third version (IES-3) is not available for adolescents, an at-risk population for eating disorders and body image disturbances. In the present study, we perform the validation of the IES-3 in a sample of 295 Brazilian adolescents. Confirmatory factor analysis (CFA) and exploratory structural equation modeling (ESEM) supported the original four-factor structure of the measure, after excluding IES-3 Item #6. Bifactor CFA support a global scale score. Full measurement invariance was found between male and female adolescents. Additionally, we found good convergent validity with measures of emotional eating, external eating, restrained eating, body acceptance by others, body appreciation, and body dissatisfaction. Finally, we found good internal consistency for IES-3 total scores and two subscales. Results support the use of the measure in Brazilian adolescents, allowing for future studies on eating disorder prevention and intervention. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - de Fialho, Daena Cunha AU - de Fialho DC AD - Body Image and Eating Disorders Research Group (NICTA), Federal University of Juiz de Fora, Governador Valadares, Brazil. Electronic address: daena.cunha@estudante.ufjf.br. FAU - Tylka, Tracy L AU - Tylka TL AD - Department of Psychology, Ohio State University, United States. Electronic address: tylka.2@osu.edu. FAU - Resende, Thaina Richelli Oliveira AU - Resende TRO AD - Body Image and Eating Disorders Research Group (NICTA), Federal University of Juiz de Fora, Governador Valadares, Brazil. Electronic address: thaina.richelli@gmail.com. FAU - da Silva, Wanderson Roberto AU - da Silva WR AD - Eating Disorders Program, Institute of Psychiatry (AMBULIM), University of Sao Paulo, Sao Paulo, Brazil. Electronic address: wandersonroberto22@gmail.com. FAU - Alvarenga, Marle Dos Santos AU - Alvarenga MDS AD - Post-graduation Program in Public Health Nutrition, School of Public Health, University of Sao Paulo, Brazil. Electronic address: marlealvarenga@gmail.com. FAU - de Carvalho, Pedro Henrique Berbert AU - de Carvalho PHB AD - Body Image and Eating Disorders Research Group (NICTA), Federal University of Juiz de Fora, Governador Valadares, Brazil; Eating Disorders Program, Institute of Psychiatry (AMBULIM), University of Sao Paulo, Sao Paulo, Brazil. Electronic address: pedro.berbert@ufjf.br. LA - eng PT - Journal Article PT - Validation Study DEP - 20260518 PL - United States TA - Eat Behav JT - Eating behaviors JID - 101090048 SB - IM MH - Humans MH - Adolescent MH - Female MH - Brazil MH - Male MH - Psychometrics MH - Reproducibility of Results MH - *Body Image/psychology MH - *Feeding Behavior/psychology MH - Factor Analysis, Statistical MH - *Feeding and Eating Disorders/psychology/diagnosis MH - Surveys and Questionnaires MH - Body Satisfaction MH - Body Dissatisfaction/psychology MH - *Intuition MH - Emotional Eating OTO - NOTNLM OT - Body acceptance OT - Body appreciation OT - Body dissatisfaction OT - Disordered eating OT - Intuitive eating OT - Measurement OT - Psychometrics COIS- Declaration of competing interest The authors have no conflicts of interest to declare that are relevant to the content of this article. EDAT- 2026/05/21 05:33 MHDA- 2026/05/29 15:45 CRDT- 2026/05/20 18:07 PHST- 2026/03/21 00:00 [received] PHST- 2026/05/13 00:00 [revised] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/05/29 15:45 [medline] PHST- 2026/05/21 05:33 [pubmed] PHST- 2026/05/20 18:07 [entrez] AID - S1471-0153(26)00026-7 [pii] AID - 10.1016/j.eatbeh.2026.102093 [doi] PST - ppublish SO - Eat Behav. 2026 Apr;61:102093. doi: 10.1016/j.eatbeh.2026.102093. Epub 2026 May 18. PMID- 42160824 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260611 IS - 1873-491X (Electronic) IS - 0020-7489 (Linking) VI - 181 DP - 2026 Sep TI - Tailored profiles of physical activity in children with asthma: Insights from a mixed methods study. PG - 105575 LID - S0020-7489(26)00247-6 [pii] LID - 10.1016/j.ijnurstu.2026.105575 [doi] AB - BACKGROUND: Physical activity participation among children with asthma is highly variable and cannot be explained by disease severity alone. Understanding distinct patterns of activity engagement and their underlying mechanisms may help inform more tailored support strategies. OBJECTIVE: To identify distinct physical activity profiles in children with asthma and to explore the lived experiences and family processes underlying these profiles using a mixed-methods design. METHODS: An explanatory sequential mixed-methods study was conducted in two phases. In the quantitative phase, 243 children with asthma aged 6-17 years were consecutively recruited between March 2024 and February 2025 from respiratory outpatient clinics of two tertiary hospitals in Zhejiang Province, China. Measures assessed physical activity, asthma control, breathlessness-related fear, perceived physical competence, and parental activity support. Person-centered profile modeling was used to identify distinct profiles. In the qualitative phase, 16 child-parent dyads (4 per profile) were purposively selected for semi-structured interviews between June and September 2025. Joint display analysis was used to integrate quantitative patterns with lived experiences. RESULTS: Four distinct profiles were identified. Profile 1, Fearful Avoiders (14.4%), showed the lowest activity, poorest asthma control, highest symptom fear, and lowest physical competence; qualitative findings suggested a self-reinforcing cycle of fear, avoidance, and reduced confidence. Profile 2, Unsupported Potentials (15.6%), showed predominantly moderate activity, the lowest parental support, and predominantly partial asthma control; interviews suggested that symptom stability was often interpreted as "good enough," leading families to disengage from active lifestyle support. Profile 3, Struggling Strivers (21.4%), maintained moderate activity despite elevated symptom fear and intermediate psychosocial outcomes; qualitative data suggested that activity was often sustained under peer and family pressure rather than through genuine confidence. Profile 4, Supported Thrivers (48.6%), demonstrated the most favorable pattern, with higher activity, better asthma control, lower fear, stronger perceived competence, and greater parental support. External validation supported the clinical relevance of the profiles, with significant between-profile differences in depression, anxiety, quality of life, and exercise adherence (all p < .001). CONCLUSION: Physical activity participation in children with asthma appears to be shaped by interacting physiological, psychological, and family processes rather than by disease severity alone. Similar activity levels may reflect very different underlying mechanisms, including disengagement, fear-driven persistence, or adaptive self-management. These findings suggest that support for physical activity in pediatric asthma may need to be tailored to profile-specific behavioral and family mechanisms. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Lin, Nan AU - Lin N AD - Department of Nursing, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang, China. FAU - Sun, Ye AU - Sun Y AD - Department of Nursing, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang, China. FAU - Jin, Jingyi AU - Jin J AD - Department of Neonatal Surgery, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang, China. FAU - Lai, Dengming AU - Lai D AD - Department of Neonatal Surgery, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang, China. Electronic address: dengming_lai@zju.edu.cn. FAU - Chen, Zhimin AU - Chen Z AD - Department of Pulmonology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang, China. Electronic address: zmchen@zju.edu.cn. FAU - Xu, Hongzhen AU - Xu H AD - Department of Nursing, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang, China. Electronic address: 6184020@zju.edu.cn. LA - eng PT - Journal Article DEP - 20260520 PL - England TA - Int J Nurs Stud JT - International journal of nursing studies JID - 0400675 SB - IM MH - Humans MH - Child MH - *Asthma/physiopathology/psychology MH - Adolescent MH - Male MH - *Exercise MH - Female OTO - NOTNLM OT - Asthma OT - Children OT - Family support OT - Mixed-methods research OT - Person-centered profiles OT - Physical activity COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Hongzhen Xu reports article publishing charges was provided by Zhejiang University School of Medicine Children's Hospital. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/21 05:33 MHDA- 2026/06/11 18:35 CRDT- 2026/05/20 18:02 PHST- 2026/01/06 00:00 [received] PHST- 2026/05/05 00:00 [revised] PHST- 2026/05/10 00:00 [accepted] PHST- 2026/06/11 18:35 [medline] PHST- 2026/05/21 05:33 [pubmed] PHST- 2026/05/20 18:02 [entrez] AID - S0020-7489(26)00247-6 [pii] AID - 10.1016/j.ijnurstu.2026.105575 [doi] PST - ppublish SO - Int J Nurs Stud. 2026 Sep;181:105575. doi: 10.1016/j.ijnurstu.2026.105575. Epub 2026 May 20. PMID- 42160790 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260914 IS - 1872-6976 (Electronic) IS - 0167-4943 (Linking) VI - 149 DP - 2026 Oct TI - Development and validation of a GDF-15-albumin-CRP score for predicting Cachexia in Asian patients with decompensated cirrhosis. PG - 106305 LID - S0167-4943(26)00175-5 [pii] LID - 10.1016/j.archger.2026.106305 [doi] AB - BACKGROUND & AIMS: Cachexia is prevalent and prognostically adverse in decompensated cirrhosis. Diagnosis is challenging, especially in Asian populations, due to limitations of current criteria and scoring systems. This study aimed to develop and validate a biomarker-based model for predicting cachexia defined by the Asian Working Group for Cachexia (AWGC) in cirrhotic patients. METHODS: In this retrospective cohort study, 420 patients with decompensated cirrhosis were enrolled (295 in the training cohort, 125 in the external validation cohort). Cachexia was diagnosed according to AWGC criteria. LASSO regression selected predictive serum biomarkers. A nomogram-derived GDF-15-Albumin-CRP score was constructed, and its performance was evaluated using the area under the receiver operating characteristic curve (AUC), calibration, and decision curve analysis (DCA). RESULTS: In the training cohort, 158 patients (53.56%) had cachexia. LASSO regression identified serum growth differentiation factor-15 (GDF-15), albumin, and C-reactive protein (CRP) as the strongest predictors. The resulting GDF-15-Albumin-CRP score achieved an AUC of 0.736 (95% CI: 0.680-0.792) for cachexia prediction, significantly outperforming Child-Turcotte-Pugh (CTP), Model for End-Stage Liver Disease (MELD), and MELD-Na scores (all P < 0.05). DCA demonstrated clinical net benefit across a wide range of threshold probabilities. The score exhibited a strong risk gradient for cachexia (adjusted OR for the high- vs. low-risk group: 7.58; 95% CI: 2.68-21.46). External validation confirmed its performance (AUC = 0.723, 95% CI: 0.630-0.810). CONCLUSIONS: The GDF-15-Albumin-CRP score is a validated and clinically feasible tool predicting AWGC-defined cachexia in Asian cirrhotic patients, superior to traditional severity scores and potentially enabling earlier targeted intervention. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Yao, Shuangzhe AU - Yao S AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin, China. FAU - Peng, Binbin AU - Peng B AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin, China. FAU - Ren, Lingyu AU - Ren L AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin, China. FAU - Yang, Ziyi AU - Yang Z AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin, China. FAU - Jiang, Kui AU - Jiang K AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin, China. Electronic address: kjiang@tmu.edu.cn. FAU - Sun, Chao AU - Sun C AD - Department of Gastroenterology, The First Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, 710077, China. Electronic address: chaosun@tmu.edu.cn. LA - eng PT - Journal Article PT - Validation Study DEP - 20260516 PL - Netherlands TA - Arch Gerontol Geriatr JT - Archives of gerontology and geriatrics JID - 8214379 RN - 0 (Growth Differentiation Factor 15) RN - 9007-41-4 (C-Reactive Protein) RN - 0 (Biomarkers) RN - 0 (GDF15 protein, human) RN - 0 (Serum Albumin) SB - IM MH - Humans MH - Female MH - *Liver Cirrhosis/complications/blood MH - Retrospective Studies MH - *Growth Differentiation Factor 15/blood MH - Male MH - *Cachexia/diagnosis/etiology/blood MH - *C-Reactive Protein/analysis/metabolism MH - Middle Aged MH - Biomarkers/blood MH - Aged MH - *Serum Albumin/analysis MH - Predictive Value of Tests MH - ROC Curve MH - Prognosis MH - Asian People OTO - NOTNLM OT - AWGC consensus OT - Cachexia OT - Growth differentiation factor-15 OT - Liver cirrhosis OT - Predictive model COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/20 18:33 MHDA- 2026/06/12 18:41 CRDT- 2026/05/20 18:00 PHST- 2026/03/17 00:00 [received] PHST- 2026/05/09 00:00 [revised] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/06/12 18:41 [medline] PHST- 2026/05/20 18:33 [pubmed] PHST- 2026/05/20 18:00 [entrez] AID - S0167-4943(26)00175-5 [pii] AID - 10.1016/j.archger.2026.106305 [doi] PST - ppublish SO - Arch Gerontol Geriatr. 2026 Oct;149:106305. doi: 10.1016/j.archger.2026.106305. Epub 2026 May 16. PMID- 42160200 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260802 IS - 1532-7914 (Electronic) IS - 0163-5581 (Linking) VI - 78 IP - 6 DP - 2026 TI - Treatment-Associated Changes in Taste Perception and PROP Bitterness Responsiveness in Children with Solid Tumors: Associations with Gastrointestinal Symptoms and Nutritional Risk. PG - 435-443 LID - 10.1080/01635581.2026.2674928 [doi] AB - Taste dysfunction is increasingly recognized as a treatment-related adverse effect in pediatric oncology and may contribute to nutritional vulnerability. This prospective longitudinal study evaluated 60 children aged 8-18 years with solid tumors at an early-treatment baseline, defined as within the first month after diagnosis and following completion of the first chemotherapy cycle, and during treatment at months 2 and 4. Twenty healthy peers served as baseline controls. Self-reported taste alterations were assessed using a validated self-report instrument, and gastrointestinal symptoms and nutritional risk were evaluated using standardized scales. Subjective taste alterations increased during therapy, while objective PROP testing indicated progressively reduced bitterness responsiveness. Gastrointestinal symptom burden also increased significantly over time. Nutritional risk scores were positively correlated with both gastrointestinal symptom severity (r = 0.30-0.42, p < 0.05) and taste alteration scores (r = 0.28-0.43, p < 0.05). Children receiving multimodal treatment tended to exhibit more pronounced sensory alterations and higher nutritional risk. These findings suggest that treatment-associated taste changes co-occur with greater gastrointestinal symptom burden and higher nutritional risk in children with solid tumors. Longitudinal assessment of sensory changes may help identify patients at increased nutritional vulnerability during oncological therapy. FAU - Misirlioglu, Penbe Ecem AU - Misirlioglu PE AD - Department of Nutrition and Dietetics, Avrasya University, Trabzon, Turkiye. FAU - Kose, Beril AU - Kose B AD - Department of Nutrition and Dietetics, Baskent University, Ankara, Turkiye. FAU - Kantar, Mehmet AU - Kantar M AD - Department of Pediatric Oncology, Ege University Faculty of Medicine, Tulay Aktas Oncology Hospital, Izmir, Turkiye. FAU - Hopanci Bicakli, Derya AU - Hopanci Bicakli D AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Mugla Sitki Kocman University, Mugla, Turkiye. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260520 PL - United States TA - Nutr Cancer JT - Nutrition and cancer JID - 7905040 RN - 0 (Antineoplastic Agents) SB - IM MH - Humans MH - Child MH - Female MH - Male MH - Adolescent MH - Prospective Studies MH - Longitudinal Studies MH - *Neoplasms/drug therapy/therapy MH - *Taste Perception/drug effects MH - *Taste Disorders/chemically induced/etiology MH - *Gastrointestinal Diseases/etiology/chemically induced MH - Nutritional Status MH - *Taste/drug effects MH - *Antineoplastic Agents/adverse effects EDAT- 2026/05/20 18:33 MHDA- 2026/05/28 00:30 CRDT- 2026/05/20 12:53 PHST- 2026/05/28 00:30 [medline] PHST- 2026/05/20 18:33 [pubmed] PHST- 2026/05/20 12:53 [entrez] AID - 10.1080/01635581.2026.2674928 [doi] PST - ppublish SO - Nutr Cancer. 2026;78(6):435-443. doi: 10.1080/01635581.2026.2674928. Epub 2026 May 20. PMID- 42159937 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2509-9280 (Electronic) IS - 2509-9280 (Linking) VI - 10 IP - 1 DP - 2026 May 20 TI - Predicting resistance to neoadjuvant chemotherapy in osteosarcoma using machine learning with clinical data and T2-weighted MRI radiomics. LID - 10.1186/s41747-026-00732-z [doi] LID - 69 AB - OBJECTIVES: Identifying patients at risk of chemoresistant osteosarcoma enables risk-adapted management. This study aimed to predict chemoresistant osteosarcoma using baseline clinical and magnetic resonance (MRI)-derived radiomics features, with histological response as the reference standard and external validation included. MATERIALS AND METHODS: This retrospective single-center study included 115 patients with osteosarcoma from an institutional registry as the internal cohort, divided into training and test sets, and 49 patients from another institution as an external validation cohort. Tumor and peritumoral regions were manually segmented on baseline fat-suppressed T2-weighted MRI. Radiomics features were extracted using PyRadiomics, followed by two feature selection methods to identify potential predictors. Six machine learning models with varying feature combinations were trained to classify histologic chemoresistance in the internal training set. Model performance was assessed in the internal test set, and the best model was externally validated. RESULTS: The support vector machine model combining eight tumor radiomics features and four clinical-imaging parameters (presence of tumor necrosis > 50% on contrast-enhanced MRI, age, body mass index, and presence of metastasis at presentation) demonstrated the best performance. In the internal test set, it achieved a sensitivity of 83.3%, a specificity of 72.7%, an area under the receiver operating characteristic curve (AUROC) of 0.84, and a positive likelihood ratio of 3.06. External validation yielded a sensitivity of 88.5%, a specificity of 47.8%, and an AUROC of 0.77. CONCLUSION: A model combining tumor radiomics and clinical parameters at diagnosis showed strong performance in predicting chemoresistant osteosarcoma, with results confirmed by external validation. This approach may support personalized treatment strategies in high-grade osteosarcoma. RELEVANCE STATEMENT: The validated model may support early, individualized osteosarcoma management. KEY POINTS: Baseline T2-weighted MRI radiomics and clinical data can predict chemoresistant osteosarcoma. Tumor radiomics combined with clinical features achieved strong predictive accuracy. The support vector machine model reached an AUROC of 0.84 for the internal testing and of 0.77 for the external validation. The validated model may support early, individualized osteosarcoma management. CI - (c) 2026. The Author(s). FAU - Inkeaw, Papangkorn AU - Inkeaw P AD - Data Science Research Center, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand. AD - Global Health and Chronic Conditions Research Group, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. AD - Department of Computer Science, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand. FAU - Pruksakorn, Dumnoensun AU - Pruksakorn D AD - Department of Orthopedics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. AD - Center of Multidisciplinary Technology for Advanced Medicine (CMUTEAM), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. FAU - Angkurawaranon, Salita AU - Angkurawaranon S AD - Global Health and Chronic Conditions Research Group, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. AD - Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. FAU - Morakote, Wipawee AU - Morakote W AD - Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. FAU - Boonsri, Pattira AU - Boonsri P AD - Department of Radiology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand. FAU - Phettom, Rattanathon AU - Phettom R AD - Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. FAU - Kanthawang, Thanat AU - Kanthawang T AUID- ORCID: 0000-0002-1980-1903 AD - Center of Multidisciplinary Technology for Advanced Medicine (CMUTEAM), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. thanatkanthawang@gmail.com. AD - Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. thanatkanthawang@gmail.com. LA - eng PT - Journal Article DEP - 20260520 PL - England TA - Eur Radiol Exp JT - European radiology experimental JID - 101721752 SB - IM MH - Humans MH - *Osteosarcoma/drug therapy/diagnostic imaging MH - *Radiomics MH - *Magnetic Resonance Imaging/methods MH - Retrospective Studies MH - *Drug Resistance, Neoplasm MH - Female MH - *Bone Neoplasms/drug therapy/diagnostic imaging MH - *Machine Learning MH - *Neoadjuvant Therapy MH - Male MH - Adolescent MH - Adult MH - Young Adult MH - Child MH - Predictive Learning Models PMC - PMC13191004 OTO - NOTNLM OT - Artificial intelligence OT - Drug resistance (neoplasm) OT - Magnetic resonance imaging OT - Osteosarcoma OT - Radiomics COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Institutional Review Board of Chiang Mai University (approval no. RAD-2566-0535) and the Institutional Review Board of Prince of Songkla University (approval no. 68-111-7-1). A data-sharing agreement was established between both institutions. The requirement for written informed consent was waived because this study involved retrospective data collection. Consent for publication: Written informed consent for publication of de-identified clinical information and imaging data was obtained from all patients in the internal dataset cohort. For the external dataset, all data and images were fully anonymized, and no directly or indirectly identifiable information is presented. Therefore, consent for publication is not applicable for the external dataset. Competing interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/20 12:39 MHDA- 2026/05/20 12:40 PMCR- 2026/05/20 CRDT- 2026/05/20 11:20 PHST- 2025/10/21 00:00 [received] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/03/24 00:00 [revised] PHST- 2026/05/20 12:40 [medline] PHST- 2026/05/20 12:39 [pubmed] PHST- 2026/05/20 11:20 [entrez] PHST- 2026/05/20 00:00 [pmc-release] AID - 10.1186/s41747-026-00732-z [pii] AID - 732 [pii] AID - 10.1186/s41747-026-00732-z [doi] PST - epublish SO - Eur Radiol Exp. 2026 May 20;10(1):69. doi: 10.1186/s41747-026-00732-z. PMID- 42159483 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260730 IS - 1539-2570 (Electronic) IS - 0271-6798 (Linking) VI - 46 IP - 7 DP - 2026 Aug 1 TI - Is the Greulich and Pyle Bone Atlas Suitable When Measuring Bone Age for Pediatric ACL Reconstruction in the Modern US Population? Analysis Within the PLUTO Prospective Multicenter Cohort Study. PG - 442-449 LID - 10.1097/BPO.0000000000003340 [doi] AB - BACKGROUND: A reliable measure of bone age is of critical importance when planning anterior cruciate ligament reconstruction (ACLR) in a pediatric population. The Greulich and Pyle (G&P) method is still the most common method for bone age determination; however, it is based on radiographs from healthy Caucasian children of high socioeconomic status (SES) in Cleveland, Ohio, in the 1920s to 1940s and may not reflect the modern diverse United States population. The aim of our study was therefore to assess the degree of agreement between chronological age and bone age measured using G&P and further investigate whether there are any systematic differences across race, ethnicity, or SES. METHODS: This was a retrospective subanalysis of PLUTO (Pediatric ACL: Understanding Treatment Options), a prospective multicenter cohort study investigating outcomes in pediatric ACLR. All patients with bone age scores using the G&P method preoperatively were included. Data on race, ethnicity, biological sex, BMI, and SES [using a composite marker known as the area deprivation index (ADI)] were collected. Bland-Altman analysis was used to assess the agreement between chronological-measured and G&P-measured age. Systematic bias was defined as a significant mean difference between chronological-measured and G&P-measured age and was determined using Student t test for the cohort and within strata; and differences across strata were determined using a one-way ANOVA. P -values across strata were adjusted using the method of Benjamini and Hochberg to control the false discovery rate. RESULTS: A total of 472 patients were included in the final analysis. Chronological age at evaluation was lower than the determined bone age for the cohort with a systematic bias of 2.9 months (SD, 12.8) ( P <0.001). The Bland-Altman 95% limits of agreement between bone age and chronological age were approximately 2 years. There was significant variation in agreement in those aged 11 to 12 ( P <0.001), 13 ( P =0.008), and 15 years ( P =0.008). Female patients had a 3.9-month greater bias compared with males ( P =0.003). Underweight patients exhibited nearly 15.9 months lower bone age versus chronological age ( P =0.008). No systematic biases were detected across ethnicity ( P =0.21), race (0.13), or ADI index quartiles ( P =0.23). CONCLUSION: Our study supports the continued use of G&P for bone age assessment across different racial, ethnic, and sociodemographic groups, with no significant differences detected across these strata. The observed approximately 2-year limits of agreement between G&P bone age and chronological age reinforce the importance of skeletal age assessment in this cohort, particularly during the peripubertal period where large differences between chronological and skeletal age can exist. Systematic biases were found in certain age strata, between sexes, and in patients with low BMI. Clinicians should be aware of these variations and consider using multiple methods of assessing skeletal maturity when making growth-sensitive clinical decisions. LEVEL OF EVIDENCE: Level III-retrospective cohort. CI - Copyright (c) 2026 Wolters Kluwer Health, Inc. All rights reserved. FAU - Guevel, Borna AU - Guevel B AUID- ORCID: 0000-0002-7750-3197 AD - Boston Children's Hospital, Harvard Medical School, Boston, MA. FAU - Hutchinson, Lauren AU - Hutchinson L AD - Boston Children's Hospital, Harvard Medical School, Boston, MA. FAU - Miller, Patricia AU - Miller P AD - Boston Children's Hospital, Harvard Medical School, Boston, MA. FAU - Anderson, Christian N AU - Anderson CN AD - Tennessee Orthopaedic Alliance, Nashville, TN. FAU - Busch, Michael T AU - Busch MT AD - Children's Healthcare of Atlanta, Atlanta, GA. FAU - Chambers, Henry G AU - Chambers HG AD - Department of Orthopaedic Surgery, Rady Children's Hospital, University of California San Diego, San Diego. FAU - Christino, Melissa A AU - Christino MA AD - Boston Children's Hospital, Harvard Medical School, Boston, MA. FAU - Cordasco, Frank A AU - Cordasco FA AD - Hospital for Special Surgery, New York, NY. FAU - Edmonds, Eric W AU - Edmonds EW AD - Department of Orthopaedic Surgery, Rady Children's Hospital, University of California San Diego, San Diego. FAU - Fabricant, Peter D AU - Fabricant PD AD - Hospital for Special Surgery, New York, NY. FAU - Ganley, Theodore J AU - Ganley TJ AD - Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA. FAU - Green, Daniel W AU - Green DW AD - Hospital for Special Surgery, New York, NY. FAU - Heyworth, Benton E AU - Heyworth BE AD - Boston Children's Hospital, Harvard Medical School, Boston, MA. FAU - Lawrence, J Todd R AU - Lawrence JTR AD - Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA. FAU - Matava, Matthew J AU - Matava MJ AD - Department of Orthopaedic Surgery, Washington University in St Louis, St Louis, MO. FAU - Micheli, Lyle J AU - Micheli LJ AD - Boston Children's Hospital, Harvard Medical School, Boston, MA. FAU - Milewski, Matthew D AU - Milewski MD AD - Boston Children's Hospital, Harvard Medical School, Boston, MA. FAU - Nepple, Jeffrey J AU - Nepple JJ AD - Department of Orthopaedic Surgery, Washington University in St Louis, St Louis, MO. FAU - Parikh, Shital N AU - Parikh SN AD - Cincinnati Children's Hospital Medical Center, Cincinnati. FAU - Pennock, Andrew T AU - Pennock AT AD - Department of Orthopaedic Surgery, Rady Children's Hospital, University of California San Diego, San Diego. FAU - Perkins, Crystal A AU - Perkins CA AD - Children's Healthcare of Atlanta, Atlanta, GA. FAU - Saluan, Paul M AU - Saluan PM AD - Cleveland Clinic, Cleveland, OH. FAU - Shea, Kevin G AU - Shea KG AD - Stanford University, Stanford, CA. FAU - Wall, Eric J AU - Wall EJ AD - Cincinnati Children's Hospital Medical Center, Cincinnati. FAU - Willimon, Samuel C AU - Willimon SC AD - Children's Healthcare of Atlanta, Atlanta, GA. FAU - Kocher, Mininder S AU - Kocher MS AD - Boston Children's Hospital, Harvard Medical School, Boston, MA. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260520 PL - United States TA - J Pediatr Orthop JT - Journal of pediatric orthopedics JID - 8109053 SB - IM MH - Humans MH - *Age Determination by Skeleton/methods MH - Female MH - Male MH - Child MH - Prospective Studies MH - Adolescent MH - Retrospective Studies MH - *Anterior Cruciate Ligament Reconstruction/methods MH - United States MH - Cohort Studies MH - Anterior Cruciate Ligament/surgery OTO - NOTNLM OT - Greulich and Pyle OT - PLUTO OT - bone age OT - pediatric anterior cruciate ligament reconstruction OT - skeletal maturity COIS- The authors declare no conflicts of interest. EDAT- 2026/05/20 12:39 MHDA- 2026/07/09 00:40 CRDT- 2026/05/20 09:53 PHST- 2025/09/06 00:00 [received] PHST- 2026/03/19 00:00 [accepted] PHST- 2026/07/09 00:40 [medline] PHST- 2026/05/20 12:39 [pubmed] PHST- 2026/05/20 09:53 [entrez] AID - 01241398-990000000-01167 [pii] AID - 10.1097/BPO.0000000000003340 [doi] PST - ppublish SO - J Pediatr Orthop. 2026 Aug 1;46(7):442-449. doi: 10.1097/BPO.0000000000003340. Epub 2026 May 20. PMID- 42159251 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261009 IS - 2044-835X (Electronic) IS - 0261-510X (Linking) VI - 44 IP - 4 DP - 2026 Nov TI - 24-h movement behaviours and inhibitory control in Chinese preschoolers: A compositional data analysis approach. PG - 801-817 LID - 10.1111/bjdp.70051 [doi] AB - This study investigated the relationships between 24-h movement behaviours and both 'cool' and 'hot' inhibitory control in Chinese preschoolers. Sixty-six children aged 3-6 years participated in this study. Twenty-four hours movement behaviours were assessed using validated questionnaires measuring moderate-to-vigorous physical activity (MVPA), light physical activity (LPA), sedentary behaviour (SB), and sleep duration (SLP). 'Cool' inhibitory control was measured using the Fish Flanker task, while 'hot' inhibitory control was assessed via the Emotion Flanker task. Compositional data analysis (CoDA) and isotemporal substitution modelling were employed for statistical analysis. The results showed that 24-h movement behaviours were significantly associated with both 'cool' and 'hot' inhibitory control. Increased SB was negatively associated with both 'cool' and 'hot' inhibitory control. Longer SLP was positively associated with both 'cool' and 'hot' inhibitory control. LPA showed a significant negative association with 'hot' inhibitory control. Isotemporal substitution analyses revealed that increasing MVPA and SLP while reducing SB and LPA was associated with enhanced control performance. This study demonstrates significant associations between 24-h movement behaviour and inhibitory control in preschoolers. The findings support the development of comprehensive movement guidelines that optimize the balance between physical activity, sedentary time, and sleep to promote cognitive development in early childhood. CI - (c) 2026 British Psychological Society. FAU - Zhu, Zhaohong AU - Zhu Z AD - School of Exercise and Health Sciences, Xi'an Physical Education University, Xi'an, China. FAU - Zhang, Shichen AU - Zhang S AUID- ORCID: 0009-0001-8415-8977 AD - School of Exercise and Health Sciences, Xi'an Physical Education University, Xi'an, China. FAU - Xu, Qinyu AU - Xu Q AD - School of Exercise and Health Sciences, Xi'an Physical Education University, Xi'an, China. FAU - Chen, Yuanyuan AU - Chen Y AD - School of Exercise and Health Sciences, Xi'an Physical Education University, Xi'an, China. FAU - Mao, Junxi AU - Mao J AD - School of Exercise and Health Sciences, Xi'an Physical Education University, Xi'an, China. LA - eng PT - Journal Article DEP - 20260520 PL - England TA - Br J Dev Psychol JT - The British journal of developmental psychology JID - 8308022 RN - Chinese people SB - IM MH - Humans MH - Female MH - Male MH - Child, Preschool MH - *Inhibition, Psychological MH - Child MH - *Child Behavior/physiology MH - *Exercise/physiology MH - Sleep Duration MH - *Sedentary Behavior MH - *Executive Function/physiology MH - China MH - East Asian People OTO - NOTNLM OT - 24-h movement behaviours OT - compositional data analysis OT - isotemporal substitution OT - preschool children OT - 'cool' inhibitory control OT - 'hot' inhibitory control EDAT- 2026/05/20 12:39 MHDA- 2026/10/08 17:35 CRDT- 2026/05/20 07:53 PHST- 2025/11/17 00:00 [received] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/10/08 17:35 [medline] PHST- 2026/05/20 12:39 [pubmed] PHST- 2026/05/20 07:53 [entrez] AID - 10.1111/bjdp.70051 [doi] PST - ppublish SO - Br J Dev Psychol. 2026 Nov;44(4):801-817. doi: 10.1111/bjdp.70051. Epub 2026 May 20. PMID- 42159103 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260720 IS - 1099-0496 (Electronic) IS - 1099-0496 (Linking) VI - 61 IP - 5 DP - 2026 May TI - Applicability of the Global Lung Initiative 2022 Spirometry Reference Equation Among Healthy Preschool-Aged Children in Jordan: A Comparative Study With GLI-2012 Equations. PG - e71675 LID - 10.1002/ppul.71675 [doi] AB - BACKGROUND: The Global Lung Initiative (GLI) Global 2022 spirometry equations do not require race selection at the point of interpretation, but their applicability in Middle Eastern preschool populations remains uncertain. Therefore, the present study aims to assess the applicability of the GLI global (2022) (GLI-2022) reference equations in a large sample of healthy Jordanian preschool-aged children and compare them with historically labeled GLI-2012 Caucasian (GLI-C) and Other/Mixed (GLI-O) equations. METHODS: A cross-sectional study was conducted with 911 healthy children (461 boys, 450 girls; age range 3-6 years) recruited from various regions in Jordan. Anthropometric and spirometric data (FEV(1), FVC, FEV(1)/FVC) were collected according to ATS/ERS standards. Race and ethnicity were not collected and were not used to assign equations. Instead, all participants were evaluated using each of the three equation sets. Z-Scores for each parameter were derived using the GLI-2022, GLI-C, and GLI-O equations. The validity of each equation set was evaluated by analyzing Z-score normality, performing regression analyses to detect residual bias from age and height, and assessing agreement in diagnostic classifications using Cohen's Kappa and Bland-Altman plots. RESULTS: The GLI-C equations demonstrated the closest statistical fit, with mean FEV(1) and FVC Z-scores closely centered on zero for both boys and girls. In contrast, the GLI-2022 and GLI-O equations produced significantly positive mean Z-scores for FEV(1) and FVC in both sexes (p < 0.001), indicating a systematic overestimation of lung function. The GLI-2022 equations showed significant residual anthropometric bias, with Z-scores remaining dependent on height and/or age (p < 0.01). Furthermore, the results indicated that diagnostic agreement between equations was inconsistent. CONCLUSION: The GLI-2022 race-neutral equations are not a suitable fit for preschool Jordanian children, and their use may lead to clinically significant misinterpretation of spirometric tests. These findings emphasize the critical need for population-specific reference equations for this population. CI - (c) 2026 Wiley Periodicals LLC. FAU - Al-Qerem, Walid AU - Al-Qerem W AUID- ORCID: 0000-0001-9831-7572 AD - Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan. LA - eng PT - Comparative Study PT - Journal Article PL - United States TA - Pediatr Pulmonol JT - Pediatric pulmonology JID - 8510590 SB - IM MH - Humans MH - Jordan MH - Female MH - Male MH - *Spirometry/standards/methods MH - Child, Preschool MH - Cross-Sectional Studies MH - Reference Values MH - Child MH - *Lung/physiology MH - Forced Expiratory Volume MH - Vital Capacity OTO - NOTNLM OT - Global Lung Initiative (GLI) OT - Jordanian OT - lung function OT - preschool children OT - reference equations OT - spirometry EDAT- 2026/05/20 12:38 MHDA- 2026/05/20 12:39 CRDT- 2026/05/20 06:34 PHST- 2026/03/05 00:00 [revised] PHST- 2025/08/11 00:00 [received] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/05/20 12:39 [medline] PHST- 2026/05/20 12:38 [pubmed] PHST- 2026/05/20 06:34 [entrez] AID - 10.1002/ppul.71675 [doi] PST - ppublish SO - Pediatr Pulmonol. 2026 May;61(5):e71675. doi: 10.1002/ppul.71675. PMID- 42158714 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260520 LR - 20260813 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 4 DP - 2026 Apr 30 TI - Incremental value of body composition indices in discriminating poorly controlled asthma in children: a cross-sectional study. PG - 102 LID - 10.21037/tp-2026-1-0102 [doi] LID - 102 AB - BACKGROUND: Asthma is the most common chronic respiratory disease in children, yet a considerable proportion of children have poorly controlled asthma despite advances in treatment. Traditional assessment models based on clinical indicators and lung function parameters show limited discriminatory ability. This study evaluated whether bioelectrical impedance analysis (BIA)-derived body composition indices-extracellular water-to-total body water ratio (ECW/TBW), phase angle (PhA), and visceral fat area (VFA)-improve the discrimination of poorly controlled asthma in children beyond traditional clinical assessments. METHODS: This cross-sectional study enrolled 103 children aged 6-14 years with asthma, categorized into poorly controlled (n=41) and well-controlled (n=62) groups. Two logistic regression models were constructed: a base model [age, sex, forced expiratory volume in 1 second (FEV(1)) % predicted, FEV(1)/forced vital capacity (FVC)] and an enhanced model adding body composition indices (ECW/TBW, PhA, VFA). Performance was evaluated using the area under the curve (AUC), net reclassification index (NRI), integrated discrimination improvement (IDI), and decision curve analysis. RESULTS: Children with poorly controlled asthma had elevated ECW/TBW (0.40 vs. 0.38, P<0.001) and decreased PhA (4.6 degrees vs. 5.2 degrees , P<0.001). In multivariable analysis, ECW/TBW was associated with increased risk of poorly controlled asthma [odds ratio (OR) =9.83, 95% confidence interval (CI): 3.53-27.37] and PhA was inversely associated (OR =0.17, 95% CI: 0.06-0.45). The enhanced model achieved an AUC of 0.893 vs. 0.618 for the base model (P<0.001), with sensitivity improving from 39.0% to 70.7% and specificity from 77.4% to 90.3%. The NRI was 0.446. CONCLUSIONS: BIA-derived body composition indices provided incremental discriminatory value for poorly controlled asthma beyond traditional assessment, potentially reflecting underlying systemic inflammation and metabolic disturbances. These findings warrant confirmation through multicenter studies with external validation. CI - (c) AME Publishing Company. FAU - Wang, Zhiyuan AU - Wang Z AUID- ORCID: 0000-0001-7990-9740 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. FAU - Zhao, Junlin AU - Zhao J AUID- ORCID: 0009-0002-9080-9622 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. FAU - Wang, Yanan AU - Wang Y AUID- ORCID: 0009-0008-3176-160X AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. FAU - Dai, Qianqian AU - Dai Q AUID- ORCID: 0009-0005-7647-0812 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. FAU - Wang, Xueli AU - Wang X AUID- ORCID: 0009-0003-3150-069X AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. FAU - Cui, Jianjiang AU - Cui J AUID- ORCID: 0009-0003-9767-7420 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. FAU - Ru, Liang AU - Ru L AUID- ORCID: 0009-0002-2200-3889 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. LA - eng PT - Journal Article DEP - 20260428 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13181688 OTO - NOTNLM OT - Asthma OT - bioelectrical impedance analysis (BIA) OT - body composition OT - child OT - cross-sectional study COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-1-0102/coif). The authors have no conflicts of interest to declare. EDAT- 2026/05/20 06:31 MHDA- 2026/05/20 06:32 PMCR- 2026/04/30 CRDT- 2026/05/20 04:43 PHST- 2026/01/26 00:00 [received] PHST- 2026/03/17 00:00 [accepted] PHST- 2026/05/20 06:32 [medline] PHST- 2026/05/20 06:31 [pubmed] PHST- 2026/05/20 04:43 [entrez] PHST- 2026/04/30 00:00 [pmc-release] AID - tp-15-04-102 [pii] AID - 10.21037/tp-2026-1-0102 [doi] PST - ppublish SO - Transl Pediatr. 2026 Apr 30;15(4):102. doi: 10.21037/tp-2026-1-0102. Epub 2026 Apr 28. PMID- 42158662 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260520 LR - 20260813 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 4 DP - 2026 Apr 30 TI - Comparison of DLIR-H and ASIR algorithms for image reconstruction in low-dose chest CT of pediatric mycoplasma pneumoniae pneumonia: a cross-sectional study. PG - 101 LID - 10.21037/tp-2025-1-923 [doi] LID - 101 AB - BACKGROUND: Pediatric Mycoplasma pneumoniae pneumonia (MPP) accounts for a significant number of cases of community-acquired pneumonia, and chest computed tomography (CT) is critical for its early diagnosis and prognosis assessment. However, clinical utilization is restricted due to concerns regarding radiation exposure. Adaptive statistical iterative reconstruction (ASIR) has been extensively employed in low-dose pediatric CT but suffers from noise texture distortion. In contrast, deep learning image reconstruction (DLIR) has shown promise for enhancing image quality in adult CT. Nevertheless, the comparative effectiveness of DLIR and ASIR in low-dose chest CT for pediatric MPP remains unvalidated, presenting a significant knowledge gap that this study endeavours to bridge. METHODS: In this retrospective cross-sectional study, consecutive pediatric patients who underwent low-dose chest CT (September 2023-March 2024) who were positive for MP-IgM and negative for other respiratory pathogen antibodies were included; patients with incomplete data, poor scan cooperation or a body mass index (BMI) >/=25 kg/m(2) were excluded. The raw CT data were reconstructed via ASIR at 0%, 50%, and 80% blending factors and DLIR at low, medium, and high-strength (DLIR-H) levels, using a standard kernel and a 1.25 mm slice thickness/interval. The standard deviation value of subcutaneous fat, the signal-to-noise ratio (SNR) of the lung parenchyma, and the contrast-to-noise ratio (CNR) of MPP were used to objectively evaluate the image quality. The subjective evaluation was scored by two senior radiologists using a 5-point scoring method, and the intraclass correlation coefficient (ICC) was determined for consistency analysis. RESULTS: Among the 235 screened patients, 142 (77 males and 65 females) were included (8.427+/-3.706 years), with a mean BMI of 16.19+/-1.83 kg/m(2). The mean effective dose was 1.17 (0.84-2.53 mSv), which met the Chinese low-dose guidelines. DLIR-H exhibited the lowest background noise (21.69, 38.3% lower than that of ASIR-80%) and the highest CNR of MPP (28.22, 14.7% higher than that of ASIR-80%). ASIR-80% had the highest SNR of the lung parenchyma (-14.46). DLIR-H achieved the highest subjective score (4.83+/-0.400, all P<0.001 vs. others) with substantial observer consistency (ICC >0.7). CONCLUSIONS: DLIR-H outperforms ASIR variants in low-dose pediatric chest CT, with minimal background noise, the highest lesion CNR and the best subjective quality at a clinically low effective dose, enhancing radiologists' diagnostic confidence and balancing radiation safety with imaging quality. Limitations include the retrospective design, DLIR-H's inferior lung parenchyma SNR, GE-only equipment compatibility, and unassessed MPP diagnostic accuracy. Prospective multicentre validation is required for broader clinical translation. CI - (c) AME Publishing Company. FAU - Zou, Ying AU - Zou Y AD - Department of Radiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. AD - Department of Radiology, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China. FAU - Bi, Hai AU - Bi H AD - Department of Radiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. AD - Department of Radiology, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China. FAU - Yang, Shouhong AU - Yang S AD - Department of Radiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. AD - Department of Radiology, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China. FAU - Li, Ruishi AU - Li R AD - Department of Pediatrics, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. AD - Department of Pediatrics, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China. FAU - Tan, Junyan AU - Tan J AD - Department of Radiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. AD - Department of Radiology, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China. FAU - Guo, Qingwei AU - Guo Q AD - Department of Radiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. AD - Department of Radiology, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China. FAU - Lu, Xiudi AU - Lu X AD - Department of Radiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. AD - Department of Radiology, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China. FAU - Liu, Jihua AU - Liu J AD - Department of Radiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. AD - Department of Radiology, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China. LA - eng PT - Journal Article DEP - 20260428 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13181691 OTO - NOTNLM OT - Mycoplasma pneumoniae OT - X-ray computed tomography OT - deep learning OT - qualitative evaluation OT - radiation dosage COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2025-1-923/coif). The authors have no conflicts of interest to declare. EDAT- 2026/05/20 06:31 MHDA- 2026/05/20 06:32 PMCR- 2026/04/30 CRDT- 2026/05/20 04:42 PHST- 2025/12/19 00:00 [received] PHST- 2026/03/18 00:00 [accepted] PHST- 2026/05/20 06:32 [medline] PHST- 2026/05/20 06:31 [pubmed] PHST- 2026/05/20 04:42 [entrez] PHST- 2026/04/30 00:00 [pmc-release] AID - tp-15-04-101 [pii] AID - 10.21037/tp-2025-1-923 [doi] PST - ppublish SO - Transl Pediatr. 2026 Apr 30;15(4):101. doi: 10.21037/tp-2025-1-923. Epub 2026 Apr 28. PMID- 42156949 OWN - NLM STAT- MEDLINE DCOM- 20260721 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 May 19 TI - Prevalence of irritable bowel syndrome and its association with lifestyle factors among medical students in Jordan: a cross-sectional survey. LID - 10.1038/s41598-026-52741-y [doi] LID - 22751 AB - Irritable Bowel Syndrome (IBS) is a common functional gastrointestinal disorder marked by chronic abdominal discomfort and altered bowel habits, including constipation, diarrhea, or a combination of both. It significantly impacts quality of life and is often linked to psychological stress and dietary factors. Given the scarcity of multi-university data from Jordan, this study aimed to determine the prevalence of IBS among medical students across three Jordanian universities and to identify associated lifestyle, psychological, and demographic risk factors using validated instruments. A cross-sectional survey was conducted among medical students from the University of Jordan, Mutah University, and Jordan University of Science and Technology across all academic levels. The Rome III criteria were employed to diagnose IBS. Sleep quality was evaluated using the SATED (Satisfaction, Alertness, Timing, Efficiency, and Duration) scale, and mental health status was assessed using the Hospital Anxiety and Depression Scale (HADS). A total of 572 students completed the questionnaire. IBS was identified in 33.74% of respondents. Among those with IBS, 31.1% had the constipation-predominant subtype, 18.1% had the diarrhea-predominant subtype, and 50.8% experienced mixed symptoms. Binary logistic regression revealed that a family history of IBS significantly increased the likelihood of having the disorder (OR: 1.95; 95% CI: 1.34-2.83). Other significant risk factors included smoking (OR: 1.43; 95% CI: 1.08-2.40) and anxiety borderline anxiety (OR: 1.76; 95% CI: 1.11-2.80; p = 0.01). Established anxiety (OR: 1.53; p = 0.06) did not reach statistical significance. Sixth-year students were found to be at highest risk (OR: 5.16; 95% CI: 1.84-14.41), possibly due to greater academic pressure. Regular physical activity was associated with lower IBS odds, though this did not reach statistical significance (OR: 0.6; p = 0.07). No significant association was found with gender, BMI, sleep quality, junk food consumption, or depression. IBS is prevalent among Jordanian medical students and is associated with both genetic predisposition and lifestyle factors. These findings underscore the importance of targeted mental health and lifestyle interventions - particularly for sixth-year students - and highlight the need for longitudinal research to establish causal pathways. To our knowledge, this is the first multi-university study in Jordan to simultaneously assess psychological, sleep, and lifestyle correlates of IBS in medical students using validated instruments, providing a foundation for evidence-based student health policy in the region. CI - (c) 2026. The Author(s). FAU - Alzoubi, Mohammad Nasri AU - Alzoubi MN AD - Department of General Surgery, Jordan University Hospital, The University of Jordan, Amman, Jordan. FAU - Aldhliki, Ameer Burhan AU - Aldhliki AB AD - School of Medicine, The University of Jordan, Amman, Jordan. FAU - Salameh, Hussam Eyad AU - Salameh HE AD - School of Medicine, The University of Jordan, Amman, Jordan. FAU - Al-Raymoony, Sara AU - Al-Raymoony S AD - School of Medicine, The University of Jordan, Amman, Jordan. FAU - Enayah, Majd AU - Enayah M AD - School of Medicine, The University of Jordan, Amman, Jordan. FAU - Ahmad, Hanan AU - Ahmad H AD - School of Medicine, The University of Mutah, Al-Karak, Jordan. FAU - Madi, Anas AU - Madi A AD - School of Medicine, The University of Jordan, Amman, Jordan. FAU - Al Kasem, Ahmad AU - Al Kasem A AD - School of Medicine, The University of Mutah, Al-Karak, Jordan. FAU - Abdallah, Noon AU - Abdallah N AD - School of Medicine, The University of Mutah, Al-Karak, Jordan. FAU - Safi, Yasmin AU - Safi Y AD - Department of Surgery, King Hussein Cancer Center, P.O. Box 1269, Amman, 11941, Jordan. FAU - Aljalabneh, Basim AU - Aljalabneh B AD - Department of Surgery, King Hussein Cancer Center, P.O. Box 1269, Amman, 11941, Jordan. DA.10229@KHCC.JO. LA - eng PT - Journal Article DEP - 20260519 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Jordan/epidemiology MH - *Students, Medical/psychology/statistics & numerical data MH - Female MH - Cross-Sectional Studies MH - Male MH - *Life Style MH - Prevalence MH - *Irritable Bowel Syndrome/epidemiology/psychology MH - Adult MH - Young Adult MH - Risk Factors MH - Surveys and Questionnaires MH - Quality of Life MH - Adolescent PMC - PMC13385915 OTO - NOTNLM OT - Irritable bowel syndrome OT - Jordan OT - Lifestyle factors OT - Medical students OT - Mental health OT - Prevalence COIS- Declarations. Consent to participate: Digital written consent was obtained from all participants after providing a detailed explanation of the study objectives and procedures. Participants were informed that their participation was voluntary and that they could withdraw at any time without any consequences. All completed questionnaires were kept anonymous and confidential, and all responses were used strictly for research purposes only. Access to the data was restricted to the research team, and all data were securely stored in compliance with institutional and ethical guidelines. Consent to publish: No personally identifiable information or images are included in this manuscript. Therefore, separate consent for publication was not required. Participants provided implied consent for the use of anonymized data for publication through their voluntary completion and submission of the survey. Ethics approval: This study was performed in accordance with the principles of the Declaration of Helsinki. The study was approved by the Ethics Committee of Research Council of the Faculty of Medicine at the University of Jordan (2682/2023/67). Competing interests: The authors declare no competing interests. EDAT- 2026/05/20 00:32 MHDA- 2026/07/21 06:34 PMCR- 2026/05/19 CRDT- 2026/05/19 23:41 PHST- 2025/06/29 00:00 [received] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/07/21 06:34 [medline] PHST- 2026/05/20 00:32 [pubmed] PHST- 2026/05/19 23:41 [entrez] PHST- 2026/05/19 00:00 [pmc-release] AID - 10.1038/s41598-026-52741-y [pii] AID - 52741 [pii] AID - 10.1038/s41598-026-52741-y [doi] PST - epublish SO - Sci Rep. 2026 May 19;16(1):22751. doi: 10.1038/s41598-026-52741-y. PMID- 42156819 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 May 19 TI - The impact of physical activity on rumination: a chain mediation model of executive function and metacognitive dysfunction and the examination of suppression effects. LID - 10.1038/s41598-026-51571-2 [doi] LID - 21002 AB - The present study aimed to examine the mediating roles of executive function and metacognitive dysfunction in the relationship between physical activity and rumination, as well as the suppressing effect within their parallel mediating pathways. From a cognitive architecture perspective, this study further explored the association pattern between physical activity and rumination among adolescents. A cross-sectional design was adopted in the present study, and data on physical activity, rumination, executive function and metacognitive dysfunction among adolescents were collected via a questionnaire survey and computerized neuropsychological tasks. A total of 603 Chinese adolescents were enrolled in the study (Mage = 16.058, SD = 0.828, male = 47.9%). Statistical analyses including reliability and validity analysis, confirmatory factor analysis, partial correlation analysis and structural equation model construction were conducted using SPSS 27.0 and AMOS 27.0, and the mediating effects were examined via the Bootstrap method. Physical activity was significantly associated with lower levels of rumination, with executive function and metacognitive dysfunction showing significant mediating associations. Specifically, higher levels of physical activity were associated with better executive function, which in turn was associated with lower rumination (beta = -0.141, 95% Confidence Interval [- 0.210, - 0.078]). In addition, physical activity was positively associated with metacognitive dysfunction, which was further associated with higher levels of rumination (beta = 0.091, 95% Confidence Interval [0.055, 0.133]). Similarly, higher levels of physical activity were associated with better executive function, which was further associated with lower levels of metacognitive dysfunction, and subsequently with lower rumination, and the reduction of metacognitive dysfunction can further decrease the occurrence of rumination (beta = -0.051, 95% Confidence Interval [- 0.078, - 0.029]). Furthermore, the parallel mediating pathways in the present study show inconsistent directions, presenting a statistically significant suppression effect, and the total indirect pathway effect is partially offset. The present study reveals that the relationship between physical activity and rumination may operate through multiple cognitive pathways with opposing directions, highlighting the structural roles of executive function and metacognitive dysfunction in this association. These findings provide a novel structural perspective for understanding the complexity of the psychological effects of physical activity and offer empirical references for the design of subsequent longitudinal or intervention studies. CI - (c) 2026. The Author(s). FAU - Cai, Dongsheng AU - Cai D AD - Institute of Sports Science, Nantong University, Nantong, China. FAU - Shi, Liteng AU - Shi L AD - Institute of Sports Science, Nantong University, Nantong, China. FAU - Yang, Yang AU - Yang Y AD - Institute of Sports Science, Nantong University, Nantong, China. FAU - Zhou, Yuan AU - Zhou Y AD - Institute of Sports Science, Nantong University, Nantong, China. FAU - Lu, Bochun AU - Lu B AD - Institute of Sports Science, Nantong University, Nantong, China. lubochun@ntu.edu.cn. FAU - Wang, Shimeng AU - Wang S AD - Institute of Sports Science, Nantong University, Nantong, China. wangsm@ntu.edu.cn. LA - eng GR - 23YJC890039/Humanities and Social Science Research Youth Fund, the Ministry of Education of China/ GR - 25KJD190001/Basic Science (Natural Science) Research Project for Higher Education Institutions in Jiangsu Province/ PT - Journal Article DEP - 20260519 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Executive Function/physiology MH - *Metacognition/physiology MH - *Exercise/psychology/physiology MH - Adolescent MH - *Rumination, Cognitive/physiology MH - Female MH - Male MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - Neuropsychological Tests PMC - PMC13342091 OTO - NOTNLM OT - Adolescents OT - Chain mediation OT - Cognitive structure OT - Executive function OT - Metacognitive dysfunction OT - Physical activity OT - Rumination OT - Suppressing effect COIS- Declarations. Competing interests: The authors declare no competing interests. Consent for publication: Not applicable. EDAT- 2026/05/20 00:33 MHDA- 2026/07/08 12:56 PMCR- 2026/05/19 CRDT- 2026/05/19 23:36 PHST- 2026/02/12 00:00 [received] PHST- 2026/04/28 00:00 [accepted] PHST- 2026/07/08 12:56 [medline] PHST- 2026/05/20 00:33 [pubmed] PHST- 2026/05/19 23:36 [entrez] PHST- 2026/05/19 00:00 [pmc-release] AID - 10.1038/s41598-026-51571-2 [pii] AID - 51571 [pii] AID - 10.1038/s41598-026-51571-2 [doi] PST - epublish SO - Sci Rep. 2026 May 19;16(1):21002. doi: 10.1038/s41598-026-51571-2. PMID- 42155401 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1873-7358 (Electronic) IS - 1471-0153 (Linking) VI - 61 DP - 2026 Apr TI - Sleep, mood, and binge eating: Evidence from a student sample. PG - 102092 LID - S1471-0153(26)00025-5 [pii] LID - 10.1016/j.eatbeh.2026.102092 [doi] AB - OBJECTIVE: Binge eating is a transdiagnostic symptom that occurs along a continuum and is common in the general population. Sleep difficulties are widespread in clinical eating disorders populations and carry important implications for treatment and outcome; yet it remains unclear if similar difficulties occur in individuals with undiagnosed binge eating. The present study investigated the relationship between binge eating and sleep in an undiagnosed student sample, using both objective and subjective measures of sleep quality and duration. A secondary aim was to examine whether difficulties in emotional regulation contribute to this relationship. METHOD: Sixty-nine participants without a diagnosis of an eating disorder were classified into low or moderate-to-high binge eating groups and completed a 7-day protocol in which sleep was continuously monitored via the MotionWatch 8. Validated self-report questionnaires were administered to assess low mood, sleep quality, eating disorder symptomatology, worry, daytime sleepiness, and chronotype. RESULTS: Individuals with moderate-to-high binge eating reported poorer perceived sleep alongside higher levels of low mood and worry, despite no detectable differences in actigraphy derived sleep. Low mood - but not worry - emerged as a significant mediator of the relationship between sleep and binge eating. DISCUSSION: Together, these findings highlight the importance of considering affective processes and sleep perception, rather than objective sleep alone, when examining sleep-binge eating links in undiagnosed populations. This may have important implications for sleep research in at-risk and undiagnosed eating disorders samples, as well as for the development of public health interventions. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Martinelli, Cristina AU - Martinelli C AD - City St Georges, University of London, United Kingdom; Kingston University, United Kingdom. Electronic address: cristina.martinelli@citystgeorges.ac.uk. FAU - Spano, Goffredina AU - Spano G AD - City St Georges, University of London, United Kingdom. LA - eng PT - Journal Article DEP - 20260514 PL - United States TA - Eat Behav JT - Eating behaviors JID - 101090048 SB - IM MH - Humans MH - Female MH - *Affect/physiology MH - *Bulimia/psychology/physiopathology MH - Male MH - Students/psychology MH - Young Adult MH - Adult MH - Sleep Quality MH - *Sleep/physiology MH - Chronotype MH - Surveys and Questionnaires MH - Actigraphy MH - Adolescent MH - *Sleep Wake Disorders/psychology MH - Binge-Eating Disorder/psychology MH - Anxiety/psychology MH - Emotional Regulation/physiology OTO - NOTNLM OT - Actigraphy OT - Affective symptoms OT - Binge eating OT - Eating disorders OT - Sleep COIS- Declaration of competing interest The authors report no conflict of interest to disclose. EDAT- 2026/05/20 00:35 MHDA- 2026/05/29 15:42 CRDT- 2026/05/19 18:19 PHST- 2026/01/27 00:00 [received] PHST- 2026/05/10 00:00 [revised] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/05/29 15:42 [medline] PHST- 2026/05/20 00:35 [pubmed] PHST- 2026/05/19 18:19 [entrez] AID - S1471-0153(26)00025-5 [pii] AID - 10.1016/j.eatbeh.2026.102092 [doi] PST - ppublish SO - Eat Behav. 2026 Apr;61:102092. doi: 10.1016/j.eatbeh.2026.102092. Epub 2026 May 14. PMID- 42153348 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260908 IS - 1365-3156 (Electronic) IS - 1360-2276 (Print) IS - 1360-2276 (Linking) VI - 31 IP - 9 DP - 2026 Sep TI - Epidemiological, Spatial and Predictive Analysis of Tuberculosis-Related Mortality in the Department of Risaralda (Colombia), 2020-2024. PG - 1284-1290 LID - 10.1111/tmi.70168 [doi] AB - OBJECTIVE: To analyse the epidemiological characteristics, spatial distribution and predictors of TB-related mortality in Risaralda from 2020 to 2024. METHODS: A retrospective observational study was conducted using secondary data from the National Public Health Surveillance System (SIVIGILA). Descriptive statistics, spatial analysis (choropleth maps) and binary logistic regression were used to identify sociodemographic and clinical factors associated with TB case fatality. Model performance was evaluated using ROC curves, sensitivity, specificity and 5-fold cross-validation. RESULTS: A total of 2081 confirmed TB cases were analysed, with a case fatality rate of 13.2%. Mortality was higher among individuals >/= 65 years (OR: 3.87), hospitalized patients (OR: 7.33), HIV-positive individuals (OR: 3.49), those with undernutrition (OR: 1.89), males (OR: 1.45) and Indigenous persons (OR: 1.67). The logistic model showed good discrimination (AUC: 0.82), with sensitivity of 79.2% and specificity of 73.8%. Cross-validation confirmed model stability (AUC: 0.81). Spatial analysis revealed high mortality in rural municipalities with low case burden, suggesting health inequities. CONCLUSION: TB mortality in Risaralda is influenced by age, comorbidities and social determinants, with pronounced territorial disparities. These findings support the integration of spatial and predictive tools in TB surveillance to strengthen targeted interventions and reduce mortality in high-risk populations. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Patino-Palma, Brayan Esneider AU - Patino-Palma BE AUID- ORCID: 0000-0002-6932-0980 AD - ZIPATEFI Research Group, Fundacion Universitaria del Area Andina, Pereira, Colombia. FAU - Chacon-Bambague, Sandra Yineth AU - Chacon-Bambague SY AUID- ORCID: 0009-0000-2196-8190 AD - ZIPATEFI Research Group, Fundacion Universitaria del Area Andina, Pereira, Colombia. FAU - Bermudez-Moreno, Farhlyn Paola AU - Bermudez-Moreno FP AD - GIER Research Group, Fundacion Universitaria del Area Andina, Pereira, Colombia. LA - eng PT - Journal Article PT - Observational Study DEP - 20260519 PL - England TA - Trop Med Int Health JT - Tropical medicine & international health : TM & IH JID - 9610576 SB - IM MH - Humans MH - Male MH - Retrospective Studies MH - Female MH - *Tuberculosis/mortality/epidemiology MH - Aged MH - Colombia/epidemiology MH - Middle Aged MH - Adult MH - Spatial Analysis MH - Adolescent MH - Young Adult MH - Risk Factors MH - Logistic Models MH - Child, Preschool MH - Infant PMC - PMC13533626 OTO - NOTNLM OT - Colombia OT - epidemiology OT - logistic models OT - mortality OT - risk factors OT - spatial analysis OT - tuberculosis COIS- The authors declare no conflicts of interest. EDAT- 2026/05/19 06:30 MHDA- 2026/09/01 23:34 PMCR- 2026/09/02 CRDT- 2026/05/19 05:33 PHST- 2026/02/04 00:00 [revised] PHST- 2025/07/13 00:00 [received] PHST- 2026/04/06 00:00 [accepted] PHST- 2026/09/01 23:34 [medline] PHST- 2026/05/19 06:30 [pubmed] PHST- 2026/05/19 05:33 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - TMI70168 [pii] AID - 10.1111/tmi.70168 [doi] PST - ppublish SO - Trop Med Int Health. 2026 Sep;31(9):1284-1290. doi: 10.1111/tmi.70168. Epub 2026 May 19. PMID- 42152169 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260712 LR - 20260813 IS - 2055-0928 (Electronic) IS - 2055-0928 (Linking) VI - 12 IP - 1 DP - 2026 May 18 TI - Whole and refined grains consumption and social interaction in children: a cross-sectional study. LID - 10.1186/s40795-026-01350-z [doi] LID - 133 AB - BACKGROUND: Social interaction is fundamental to a child's mental health and development. While diet is a known modulator of brain function, the specific roles of refined versus whole grain intake on social behaviors in children are not well understood. This study aimed to investigate association between refined and whole grain consumption and social interaction scores among Iranian children. METHODS: This cross-sectional study recruited 313 children aged 7-13 years from Kashan, Iran. Dietary intake was assessed using a validated 168-item food frequency questionnaire (FFQ). Social interaction was evaluated using the 40-item Social Communication Questionnaire (SCQ), where higher scores indicate greater difficulties with communication. Multivariable linear regression models were used to assess association between grain intake and SCQ scores, adjusting for a comprehensive set of demographics, socioeconomic, anthropometric, and dietary confounders. RESULTS: In the fully adjusted model, total refined grains intake was significantly associated with higher SCQ scores (beta‌: 0.007, 95% CI: 0.005, 0.009; P < 0.001). Conversely, total whole grain was associated with lower SCQ scores (beta‌: -0.006, 95% CI: -0.009, -0.002; P < 0.001). CONCLUSION: In this study, higher intake of refined grains was associated with poorer social interaction, while greater consumption of whole grains was associated with more favorable social behaviors in Iranian children. Future longitudinal and interventional studies are required to clarify the causal relationship between grain quality and social interaction in children of different countries. CI - (c) 2026. The Author(s). FAU - Aliakbari, Mohammadreza AU - Aliakbari M AD - Student Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran. FAU - Haghighat Lari, Mohammad Mehdi AU - Haghighat Lari MM AD - Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran. AD - Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. FAU - Nouri, Pania AU - Nouri P AD - Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. FAU - Mollaei, Maryam AU - Mollaei M AD - Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. FAU - Kermanizadeh Jamkarani, Zahra AU - Kermanizadeh Jamkarani Z AD - Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. FAU - Nematolahi, Faezeh AU - Nematolahi F AD - Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Milajerdi, Alireza AU - Milajerdi A AD - Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. amkhv@yahoo.com. LA - eng PT - Journal Article DEP - 20260518 PL - England TA - BMC Nutr JT - BMC nutrition JID - 101672434 PMC - PMC13359884 OTO - NOTNLM OT - Children OT - Dietary patterns OT - Refined grains OT - SCQ OT - Social interaction OT - Whole grains COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Kashan University of Medical Sciences (IR.KAUMS.MEDNT.REC.1403.117). The study was conducted in accordance with the principles of the Declaration of Helsinki. Written informed consent was obtained from the parents of all participants prior to enrollment in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/19 06:30 MHDA- 2026/05/19 06:31 PMCR- 2026/05/18 CRDT- 2026/05/19 00:19 PHST- 2026/02/20 00:00 [received] PHST- 2026/05/05 00:00 [accepted] PHST- 2026/05/19 06:31 [medline] PHST- 2026/05/19 06:30 [pubmed] PHST- 2026/05/19 00:19 [entrez] PHST- 2026/05/18 00:00 [pmc-release] AID - 10.1186/s40795-026-01350-z [pii] AID - 1350 [pii] AID - 10.1186/s40795-026-01350-z [doi] PST - epublish SO - BMC Nutr. 2026 May 18;12(1):133. doi: 10.1186/s40795-026-01350-z. PMID- 42152104 OWN - NLM STAT- MEDLINE DCOM- 20260913 LR - 20260916 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 25 IP - 1 DP - 2026 May 18 TI - Feeding problems in infancy and diet quality in later childhood: a prospective cohort study. LID - 10.1186/s12937-026-01311-z [doi] LID - 99 AB - BACKGROUND: Feeding problems affect many children, yet their connection with diet quality in later childhood is unknown, despite the important role of diet quality on health outcomes, such as obesity. OBJECTIVE: To examine feeding problem behaviors and diet quality in later childhood. DESIGN: The frequency of problematic feeding behaviors (i.e., items related to food refusal, feeding difficulties, and distress) were parent-reported at 18 and 24 months in a birth cohort (2008-2010) from New York state (n = 4,989). In this previously validated feeding behaviors scale, parents responded to how often their child engaged in behaviors such as crying/screaming during meals and food refusal, to create an average feeding problems score. Typical daily servings of food items that a child consumed were parent-reported at 30 months, 36 months, 7 years, and 9 years and diet quality using the Youth Healthy Eating Index (YHEI) was calculated, with a higher score indicating better diet quality. Mixed effects analyses calculated mean differences in YHEI per unit increase in feeding problem scores, adjusting for sociodemographic and health-related factors, such as parental education, gestational age, and any breastfeeding duration. RESULTS: Feeding problem scores at 18 and 24 months were prospectively associated with lower YHEI scores at 30/36 months (18 months: B = -1.10, 95% CI: -1.93, -0.27; 24 months: B = -1.56, 95% CI: -2.33, -0.79). Similar associations were observed at 7/9 years (18 months: B = -1.30, 95% CI: -2.61, 0.00; 24 months: B = -1.65, 95% CI: -2.96, -0.34). CONCLUSIONS: Higher feeding problems in infancy (18 and 24 months) were associated with lower quality diets in childhood, even after children started school. These findings highlight the importance of feeding behaviors to long-term diet quality even with observations as early as 18 months. TRIAL REGISTRATION: NCT03106493 in clinicaltrials.gov (Dates: 07/2008-11/2019, Study Registration Date: 2017-04-10). CI - (c) 2026. Akhgar Ghassabian. Parts of this work were authored by US Federal Government authors and are not under copyright protection in the US; foreign copyright protection may apply. FAU - Jankowski, Emma AU - Jankowski E AD - Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6710B Rockledge Dr, MSC 7004, Bethesda, MD, 20817, USA. AD - Division of Epidemiology, College of Public Health, The Ohio State University, Columbus, OH, 43210, USA. FAU - Putnick, Diane L AU - Putnick DL AD - Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6710B Rockledge Dr, MSC 7004, Bethesda, MD, 20817, USA. FAU - Ghassabian, Akghar AU - Ghassabian A AD - Grossman School of Medicine, New York University, New York, NY, 10016, USA. FAU - Clayton, Priscilla K AU - Clayton PK AD - Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6710B Rockledge Dr, MSC 7004, Bethesda, MD, 20817, USA. FAU - Lin, Tzu-Chun AU - Lin TC AD - Glotech, Inc., 1801 Research Boulevard #605, Rockville, MD, 20850, USA. FAU - Yeung, Edwina H AU - Yeung EH AUID- ORCID: 0000-0002-3851-2613 AD - Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6710B Rockledge Dr, MSC 7004, Bethesda, MD, 20817, USA. yeungedw@mail.nih.gov. LA - eng SI - ClinicalTrials.gov/NCT03106493 GR - contracts #HHSN275201200005C, #HHSN267200700019C, #HHSN275201400013C, #HHSN275201300026I/27500004, #HHSN275201300023I/27500017/the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH/ GR - HHSN267200700019C/HD/NICHD NIH HHS/United States GR - HHSN275201300026I/HD/NICHD NIH HHS/United States GR - HHSN275201400013C/HD/NICHD NIH HHS/United States GR - HHSN275201200005C/HD/NICHD NIH HHS/United States PT - Journal Article PT - Observational Study DEP - 20260518 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 SB - IM MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - *Diet MH - *Diet, Healthy/statistics & numerical data MH - *Feeding Behavior/psychology MH - New York/epidemiology MH - Prospective Studies PMC - PMC13573370 OTO - NOTNLM OT - Children OT - Diet quality OT - Feeding problems OT - Healthy eating COIS- Declarations. Ethics approval and consent to participate: Human subjects approval was obtained from all participating institutions (NYSDOH IRB #07-097; UAlbany #08-179), and informed consent was obtained prior to data collection. Informed consent to participate for minors (participants under the age of 16) was obtained from parents or legal guardians. All procedures performed in this study were in accordance with the ethical standards of the 1964 Helsinki Declaration and its later amendments. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/19 06:30 MHDA- 2026/09/14 05:35 PMCR- 2026/05/18 CRDT- 2026/05/19 00:16 PHST- 2025/09/11 00:00 [received] PHST- 2026/03/09 00:00 [accepted] PHST- 2026/09/14 05:35 [medline] PHST- 2026/05/19 06:30 [pubmed] PHST- 2026/05/19 00:16 [entrez] PHST- 2026/05/18 00:00 [pmc-release] AID - 10.1186/s12937-026-01311-z [pii] AID - 1311 [pii] AID - 10.1186/s12937-026-01311-z [doi] PST - epublish SO - Nutr J. 2026 May 18;25(1):99. doi: 10.1186/s12937-026-01311-z. PMID- 42151309 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 May 18 TI - Longitudinal associations between adherence to 24-h movement guidelines and physical fitness and body composition in pediatric overweight and obesity. LID - 10.1038/s41598-026-53270-4 [doi] LID - 22375 AB - This study investigated the longitudinal associations between adherence to the 24-h Movement Guidelines (24-HMG), specifically, meeting the recommendations for moderate-to-vigorous physical activity (MVPA) (>/= 60 min/day), recreational screen time ( 0.05). Fatigue index and peak force also differed notably, with post-PHV players displaying higher fatigue levels and peak force (p < 0.001). Significant differences in IMTP impulse at 100 ms and 300 ms (p < 0.001) indicated greater strength and power with advanced maturation. These findings underscore the influence of biological maturation on kinanthropometric and physical performance metrics, linking advanced maturation with increased strength and power but reduced aerobic capacity in post-PHV players, likely due to greater body mass. The results highlight the need for tailored training programs that consider both chronological and biological age to optimize player development, supporting more effective talent identification and training strategies. CI - (c)2026 Wang et al. FAU - Wang, Rou AU - Wang R AD - Sports Coaching College, Beijing Sport University, Beijing, China. FAU - Liu, Meng AU - Liu M AD - Department of Physical Education, University of Jinan, Jinan, China. FAU - Nugent, Frank AU - Nugent F AD - Physical Education & Sport Sciences, University of Limerick, Limerick, Ireland. FAU - Kearney, Philip AU - Kearney P AD - Physical Education & Sport Sciences, University of Limerick, Limerick, Ireland. FAU - Ho, Indy Man Kit AU - Ho IMK AD - Faculty of Management and Hospitality, Technological and Higher Education Institute of Hong Kong, Hong Kong, China. AD - Faculty of Kinesiology, University of Zagreb, Zagreb, Croatia. FAU - Li, Cong AU - Li C AD - Facilitate Healthy Developments for Children (Hebei) Technology Co., Ltd., Shijiazhuang, Hebei, China. FAU - Pang, Hai AU - Pang H AD - Facilitate Healthy Developments for Children (Hebei) Technology Co., Ltd., Shijiazhuang, Hebei, China. FAU - Li, Weiming AU - Li W AD - Sports Coaching College, Beijing Sport University, Beijing, China. FAU - Xu, Yaohui AU - Xu Y AD - Sports Coaching College, Beijing Sport University, Beijing, China. FAU - Liu, Haochong AU - Liu H AD - Sports Coaching College, Beijing Sport University, Beijing, China. AD - Physical Education & Sport Sciences, University of Limerick, Limerick, Ireland. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260513 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - Male MH - *Soccer/physiology MH - Adolescent MH - *Athletic Performance/physiology MH - Body Composition MH - Oxygen Consumption/physiology MH - Absorptiometry, Photon MH - Muscle, Skeletal/physiology MH - Exercise Test MH - Anthropometry PMC - PMC13179742 OTO - NOTNLM OT - Development OT - Growth OT - Kinanthropometry OT - Performance OT - Puberty OT - Skeletal maturation COIS- Cong Li and Hai Pang are employed by Facilitate Healthy Developments for Children (Hebei) Technology Co., Ltd. The authors declare that no other competing interests exist. EDAT- 2026/05/18 12:42 MHDA- 2026/05/18 12:43 PMCR- 2026/05/13 CRDT- 2026/05/18 06:39 PHST- 2025/08/27 00:00 [received] PHST- 2026/03/19 00:00 [accepted] PHST- 2026/05/18 12:43 [medline] PHST- 2026/05/18 12:42 [pubmed] PHST- 2026/05/18 06:39 [entrez] PHST- 2026/05/13 00:00 [pmc-release] AID - 21203 [pii] AID - 10.7717/peerj.21203 [doi] PST - epublish SO - PeerJ. 2026 May 13;14:e21203. doi: 10.7717/peerj.21203. eCollection 2026. PMID- 42145476 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Obesity and its relationship with lifestyle behaviors among Kuwaiti adolescents revisited after 15 years: a study protocol. PG - 1808837 LID - 10.3389/fpubh.2026.1808837 [doi] LID - 1808837 AB - BACKGROUND: Lifestyle behaviors such as physical activity, sedentary time, sleep, and dietary habits play a central role in shaping adolescent health. In Kuwait, the Arab Teens Lifestyle Study (ATLS), conducted in 2009/2010, reported that nearly half of adolescents were overweight or obese, with physical inactivity and unhealthy dietary patterns emerging as key correlates. Over the past 15 years, profound societal changes, including accelerated digitalisation and shifts in food environments, may have further altered these patterns, yet updated nationally representative data are lacking. OBJECTIVES: This study will reassess the prevalence of overweight, obesity, and lifestyle behaviors among Kuwaiti adolescents and directly compare findings with the 2009/2010 ATLS using the same methodological framework. For the first time in Kuwait, psychological wellbeing, grip strength, and objectively measured physical activity and sleep will also be assessed. METHODS: A school-based cross-sectional survey designed as a methodological revisit to the 2009/2010 ATLS will be conducted among a representative sample of 14-19-year-old students from public and private secondary schools across Kuwait using a multistage stratified cluster sampling design (target n approximately 1,320-1,350). Data collection will include standardized anthropometric measurements, validated questionnaires covering physical activity, sedentary behaviors, sleep, dietary habits, and psychological wellbeing, grip strength dynamometry, and wrist-worn accelerometery where funding permits. All inferential analyses will be conducted using survey-adjusted procedures accounting for the complex sampling design. EXPECTED OUTCOMES: This study will generate nationally representative, contemporary evidence on adolescent health behaviors in Kuwait, enable direct temporal comparisons with 2009/2010 baseline findings, and support the development of targeted public health strategies aimed at reducing obesity and improving the wellbeing of Kuwaiti adolescents. CI - Copyright (c) 2026 Alosaimi, Al-Farhan, Alkazemi and Al-Hazzaa. FAU - Alosaimi, Noura AU - Alosaimi N AD - Food and Nutrition Administration, Ministry of Health, Kuwait City, Kuwait. FAU - Al-Farhan, Abdulaziz Kh AU - Al-Farhan AK AD - Biomedical Science Department, College of Nursing, Public Authority for Applied Education and Training, Kuwait City, Kuwait. FAU - Alkazemi, Dalal U Z AU - Alkazemi DUZ AD - Department of Food Science and Nutrition, College of Life Sciences, Kuwait University, Sabah Al-Salem University, Kuwait City, Kuwait. FAU - Al-Hazzaa, Hazzaa M AU - Al-Hazzaa HM AD - Lifestyle and Health Research Center, Health Sciences Research Center, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. AD - School of Sport Sciences, University of Jordan, Amman, Jordan. LA - eng PT - Journal Article DEP - 20260501 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Adolescent MH - Kuwait/epidemiology MH - *Life Style MH - Female MH - Cross-Sectional Studies MH - Male MH - Young Adult MH - *Obesity/epidemiology MH - Prevalence MH - Sedentary Behavior MH - Exercise MH - Sleep MH - *Health Behavior MH - *Adolescent Behavior MH - Surveys and Questionnaires PMC - PMC13176217 OTO - NOTNLM OT - Kuwait OT - accelerometry OT - adolescent OT - dietary habit OT - grip strength OT - obesity OT - physical activity OT - psychological health COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/18 12:43 MHDA- 2026/05/18 12:44 PMCR- 2026/05/01 CRDT- 2026/05/18 06:35 PHST- 2026/02/11 00:00 [received] PHST- 2026/03/06 00:00 [revised] PHST- 2026/03/27 00:00 [accepted] PHST- 2026/05/18 12:44 [medline] PHST- 2026/05/18 12:43 [pubmed] PHST- 2026/05/18 06:35 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1808837 [doi] PST - epublish SO - Front Public Health. 2026 May 1;14:1808837. doi: 10.3389/fpubh.2026.1808837. eCollection 2026. PMID- 42145448 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260518 LR - 20260921 IS - 0973-2063 (Print) IS - 0973-2063 (Electronic) IS - 0973-2063 (Linking) VI - 22 IP - 3 DP - 2026 TI - A thermal cauterization therapy in dysmenorrhea pain management: A siddha case report. PG - 1555-1559 LID - 10.6026/973206300221555 [doi] AB - Dysmenorrhea is a common gynecological condition affecting nearly 70% of adolescent and young adult women in India, often leading to significant physical discomfort and disruption of daily activities. Therefore, it is of interest to investigate the therapeutic efficacy of Thermal cauterization, a traditional Siddha thermal cauterization therapy, administered to a 23-year-old female medical student with recurrent dysmenorrhea unresponsive to NSAIDs. The patient underwent three sessions of thermal cauterization therapy applied to the umbilical region five days prior to menstruation, followed by a six-month regimen of yoga, pranayamam and dietary modifications. Clinical outcomes were assessed using the WaLIDD score and the Dysmenorrhea Symptom Interference (DSI) Scale, revealing substantial improvements in pain intensity, duration, sleep quality, concentration and physical activity; working ability improved from Grade 3 (always affected) to Grade 1 (almost never affected) and pain distribution was completely resolved. Thus, we show that thermal cauterization therapy, when integrated with lifestyle interventions, offers a reproducible and patient-responsive approach for the effective management of dysmenorrhea. CI - (c) 2026 Biomedical Informatics. FAU - Kanimozhi, S AU - Kanimozhi S AD - Department of Anatomy, Sri Muthukumaran Medical College Hospital and Research Institute, Chennai-69, Tamil Nadu, India. FAU - Sathish Adithya, R AU - Sathish Adithya R AD - Department of Department of Forensic Medicine and Toxicology (Nanju Maruthuvam), National Institute of Siddha, Chennai-47, Tamil Nadu, India. LA - eng PT - Journal Article DEP - 20260331 PL - Singapore TA - Bioinformation JT - Bioinformation JID - 101258255 PMC - PMC13177125 OTO - NOTNLM OT - Siddha OT - Suttigai OT - dysmenorrhea OT - thermal cauterization OT - yoga EDAT- 2026/05/18 12:43 MHDA- 2026/05/18 12:44 PMCR- 2026/03/31 CRDT- 2026/05/18 06:34 PHST- 2026/03/01 00:00 [received] PHST- 2026/03/31 00:00 [revised] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/05/18 12:44 [medline] PHST- 2026/05/18 12:43 [pubmed] PHST- 2026/05/18 06:34 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - 973206300221555 [pii] AID - 10.6026/973206300221555 [doi] PST - epublish SO - Bioinformation. 2026 Mar 31;22(3):1555-1559. doi: 10.6026/973206300221555. eCollection 2026. PMID- 42145280 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260717 IS - 0035-7715 (Print) IS - 0035-7715 (Linking) VI - 76 IP - 4 DP - 2025 Dec 31 TI - Association of sweet taste perception and dietary habits with body mass index among public school children of Belagavi district, South India. PG - 315-322 LID - 220379 [pii] LID - 10.32394/rpzh/220379 [doi] AB - BACKGROUND: Healthy diet is significant for growth, development, and prevention from dietary related diseases in children and adults. Dietary imbalance can lead to many general and oral diseases and sugar rich diet can affect the teeth at an early age and continues towards adolescence causing several oral problems such as dental caries. Frequent consumption of a certain food causes changes in taste perception and leads to preference for that food. Taste perception may also be affected by several environmental, cultural, and genetic factors and has been found to be linked to oral health and body mass index (BMI). OBJECTIVE: This study evaluated the association between sweet taste perception, dietary habits, and body mass index among 13-15-year-old public school children in the Belagavi district. MATERIAL AND METHODS: A descriptive cross-sectional study was conducted among 1300 school children aged 13-15 years. Data were collected using a self-designed and validated questionnaire to assess dietary habits. Sweet taste perception was evaluated using sweet taste threshold (TT) and sweet taste preference (TP). Based on the sweet taste perception scores, participants were categorized into low, medium, and high groups. Body mass index was calculated using standard criteria. Descriptive statistics, Spearman's correlation test and ANOVA were performed. Statistical significance was considered for p-value /= 4 h (OR = 4.21), near work >/= 4 h (OR = 3.53), BMI >/= 24 (OR = 3.20), and sleep duration < 6 h (OR = 2.26) as independent risk factors (all p < 0.05). The risk prediction nomogram demonstrated acceptable discriminative ability (AUC: 0.74 in the training set and 0.70 in the validation set). CONCLUSION: Dry eye disease is common and under-recognized among myopic children in northern China, with risk closely linked to modifiable behavioral and lifestyle factors and Ortho-K lens use. The developed nomogram can facilitate early identification and targeted interventions for high-risk children. CI - Copyright (c) 2026 Li, Wen, Qin, Gao, Liu and Zhang. FAU - Li, Bingqing AU - Li B AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. AD - Department of Refraction, Shijiazhuang Aier Eye Hospital, Shijiazhuang, China. FAU - Wen, Jie AU - Wen J AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. FAU - Qin, Jie AU - Qin J AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. FAU - Gao, Ran AU - Gao R AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. FAU - Liu, Hanruo AU - Liu H AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. FAU - Zhang, Fengju AU - Zhang F AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. AD - Department of Refraction, Beijing Aier-Intech Eye Hospital, Beijing, China. LA - eng PT - Journal Article DEP - 20260428 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC13162332 OTO - NOTNLM OT - blink OT - body mass index OT - child OT - dry eye disease OT - myopia OT - orthokeratologic procedures OT - predictive value of tests OT - risk factors COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/14 14:21 MHDA- 2026/05/14 14:22 PMCR- 2026/04/28 CRDT- 2026/05/14 04:55 PHST- 2025/12/16 00:00 [received] PHST- 2026/03/25 00:00 [revised] PHST- 2026/04/06 00:00 [accepted] PHST- 2026/05/14 14:22 [medline] PHST- 2026/05/14 14:21 [pubmed] PHST- 2026/05/14 04:55 [entrez] PHST- 2026/04/28 00:00 [pmc-release] AID - 10.3389/fmed.2026.1768592 [doi] PST - epublish SO - Front Med (Lausanne). 2026 Apr 28;13:1768592. doi: 10.3389/fmed.2026.1768592. eCollection 2026. PMID- 42131230 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260514 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Food insecurity as an underexplored pathway linking ethnic enclave contexts and anxiety among Dominicans in the United States. PG - 1778246 LID - 10.3389/fnut.2026.1778246 [doi] LID - 1778246 AB - INTRODUCTION: Migration shapes access to food environments and practices, with implications for both nutritional and mental health. Although neighborhood ethnic concentration has been linked to mental health among Latino populations, the findings remain inconsistent, and the mechanisms are not well understood. Food insecurity, a common experience among immigrant households, may represent a key psychosocial pathway linking the neighborhood context to anxiety. Caribbean Latino populations, including Dominicans, remain underrepresented in this literature. This study examined whether Dominican ethnic concentration is associated with anxiety symptoms and whether household food insecurity mediates this relationship. METHODS: We analyzed data from a representative multi-state sample of Dominican adults in the United States (n = 662), 53% of whom were immigrants. Dominican ethnic concentration was operationalized using location quotients at the ZIP Code Tabulation Area level to capture enclave-like contexts in the data. Household food insecurity was assessed using a validated measure (low/very low; mild/high), and anxiety symptoms were measured using the Generalized Anxiety Disorder-4 scale (0 = not at all to 4 = nearly every day). Survey-weighted generalized structural equation models were used to test mediation, adjusting for age, sex, income, nativity, state of residence, and presence of children in the household. RESULTS: Nearly 30% of the respondents experienced low household food security. Higher Dominican ethnic concentration was associated with lower anxiety symptoms overall, with mean GAD-4 scores being highest in low-concentration areas and lower in higher-concentration and ethnic enclaves. In survey-weighted generalized structural equation models, low household food security was strongly associated with higher anxiety symptoms (beta = 0.586, P < 0.001). Mediation analysis indicated that household food security partially mediated the association between Dominican concentration and anxiety (p = 0.034). DISCUSSION: Greater Dominican concentration may protect against anxiety by reducing household food insecurity, highlighting food insecurity as a key pathway linking ethnic concentration to mental health. These findings underscore the importance of culturally sustaining food environments for the wellbeing of immigrants and subsequent generations born in the US. CI - Copyright (c) 2026 Florez, Bi, D'Agostino, Agarwal, Albrecht, Marrara, Abraido-Lanza and Hernandez. FAU - Florez, Karen R AU - Florez KR AD - Graduate School of Public Health and Health Policy (CUNY SPH), Center for Systems Science and Community Design, City University of New York, New York, NY, United States. FAU - Bi, Yuntian AU - Bi Y AD - Nicholas School of the Environment, Duke University, Durham, NC, United States. FAU - D'Agostino, Emily M AU - D'Agostino EM AD - Department of Population Health Sciences, Duke University School of Medicine, Durham, NC, United States. AD - Duke Center for Childhood Obesity Research, Duke University School of Medicine, Durham, NC, United States. AD - Department of Orthopedic Surgery, Occupational Therapy Division, Duke University School of Medicine, Durham, NC, United States. AD - Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, United States. AD - Duke Global Health Institute, Duke University School of Medicine, Durham, NC, United States. FAU - Agarwal, Khushboo R AU - Agarwal KR AD - Graduate School of Public Health and Health Policy (CUNY SPH), Epidemiology and Biostatistics, City University of New York, New York, NY, United States. FAU - Albrecht, Sandra S AU - Albrecht SS AD - Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, United States. FAU - Marrara, Sarah AU - Marrara S AD - School of Social Work, Columbia University, New York, NY, United States. FAU - Abraido-Lanza, Ana F AU - Abraido-Lanza AF AD - School of Social Work, Columbia University, New York, NY, United States. FAU - Hernandez, Ramona AU - Hernandez R AD - City College of New York, CUNY Dominican Studies Institute, New York, NY, United States. LA - eng PT - Journal Article DEP - 20260428 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13160777 OTO - NOTNLM OT - Dominican immigrants OT - anxiety OT - food insecurity OT - neighborhoods OT - residential segregation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/14 14:21 MHDA- 2026/05/14 14:22 PMCR- 2026/04/28 CRDT- 2026/05/14 04:51 PHST- 2025/12/30 00:00 [received] PHST- 2026/03/15 00:00 [revised] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/05/14 14:22 [medline] PHST- 2026/05/14 14:21 [pubmed] PHST- 2026/05/14 04:51 [entrez] PHST- 2026/04/28 00:00 [pmc-release] AID - 10.3389/fnut.2026.1778246 [doi] PST - epublish SO - Front Nutr. 2026 Apr 28;13:1778246. doi: 10.3389/fnut.2026.1778246. eCollection 2026. PMID- 42127560 OWN - NLM STAT- MEDLINE DCOM- 20260605 LR - 20260625 IS - 1873-2380 (Electronic) IS - 0021-9290 (Linking) VI - 204 DP - 2026 Jul TI - Validation, characterization, and utility of markerless motion capture in a large cohort of pediatric patients with complex gait patterns. PG - 113359 LID - S0021-9290(26)00214-9 [pii] LID - 10.1016/j.jbiomech.2026.113359 [doi] AB - Markerless motion capture has emerged as a potential substitute for traditional marker-based systems, offering scalable, non-invasive acquisition of human movement. Despite increasing adoption in research and sports applications, its clinical utility for children with atypical gait remains an open question. To address this gap, simultaneous marker-based and markerless data were collected in 202 children with complex gait patterns (12.1 +/- 3.9 years). Marker-based kinematics were processed using the Shriners Children's Gait Model (SCGM), while markerless outputs were computed using Theia3D with identical Cardan sequences. Agreement between systems was evaluated using statistical parametric mapping (SPM), root-mean-square error (RMSE), and a gait pattern classification based on the plantarflexor-knee extension index. Markerless output systematically underestimated pelvic tilt, hip rotation, and knee rotation and demonstrated reduced between-subject variance in the transverse plane. SPM revealed widespread waveform differences, although most were of negligible effect, especially in the sagittal plane. Mean sagittal-plane RMSEs were < 5 degrees for the knee and ankle and < 8 degrees for the pelvis and hip. Coronal-plane deviations were < 7 degrees , whereas transverse-plane errors exceeded 10 degrees . RMSE increased significantly with body mass index and use of a walker (p < 0.001). Agreement in sagittal-plane gait classification was moderate between systems (kappa = 0.60; 67% overall concordance). These results indicate that markerless motion capture is suitable for analyses emphasizing sagittal deviations but remains limited for applications requiring precise axial or frontal-plane estimation. Future work should address algorithmic underestimation of transverse motion and evaluate markerless performance across increasing severity of gait deviation. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Chafetz, Ross S AU - Chafetz RS AD - Shriners Children's Philadelphia, 3551 N Broad St, Philadelphia, PA 19140, the United States of America. Electronic address: RCHAFETZ@shrinenet.org. FAU - Warshauer, Spencer AU - Warshauer S AD - Shriners Children's Philadelphia, 3551 N Broad St, Philadelphia, PA 19140, the United States of America. Electronic address: swarshauer@shrinenet.org. FAU - Waldron, Sean AU - Waldron S AD - Shriners Children's Philadelphia, 3551 N Broad St, Philadelphia, PA 19140, the United States of America. Electronic address: Sean.Waldron@shrinenet.org. FAU - Kruger, Karen M AU - Kruger KM AD - Shriners Children's Chicago, 2211 N Oak Park Ave, Chicago, IL 60707, the United States of America. Electronic address: kkruger@shrinenet.org. FAU - Donahue, Seth AU - Donahue S AD - Shriners Children's Lexington 110 Conn Terrace, Lexington, KY 40508, the United States of America. Electronic address: Seth.Donahue@shrinenet.org. FAU - Bauer, Jeremy P AU - Bauer JP AD - Shriners Children's Portland, 3101 SW Sam Jackson Park Rd, Portland, OR 97239, the United States of America. Electronic address: jpbauer@shrinenet.org. FAU - Sienko, Susan AU - Sienko S AD - Shriners Children's Portland, 3101 SW Sam Jackson Park Rd, Portland, OR 97239, the United States of America. Electronic address: ssienko@shrinenet.org. FAU - Bagley, Anita AU - Bagley A AD - Shriners Children's Northern California, 2425 Stockton Blvd, Sacramento, CA 95817, the United States of America. Electronic address: ABagley@shrinenet.org. FAU - Courter, Robert AU - Courter R AD - Shriners Children's Philadelphia, 3551 N Broad St, Philadelphia, PA 19140, the United States of America. Electronic address: robert.courter@shrinenet.org. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20260509 PL - United States TA - J Biomech JT - Journal of biomechanics JID - 0157375 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Biomechanical Phenomena MH - Cohort Studies MH - *Gait/physiology MH - *Gait Analysis/methods MH - Knee Joint/physiology MH - *Motion Capture/methods OTO - NOTNLM OT - Kinematics OT - Markerless OT - Motion Capture OT - Pediatrics OT - Validation COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/14 00:31 MHDA- 2026/06/06 00:35 CRDT- 2026/05/13 18:06 PHST- 2026/01/29 00:00 [received] PHST- 2026/04/16 00:00 [revised] PHST- 2026/05/08 00:00 [accepted] PHST- 2026/06/06 00:35 [medline] PHST- 2026/05/14 00:31 [pubmed] PHST- 2026/05/13 18:06 [entrez] AID - S0021-9290(26)00214-9 [pii] AID - 10.1016/j.jbiomech.2026.113359 [doi] PST - ppublish SO - J Biomech. 2026 Jul;204:113359. doi: 10.1016/j.jbiomech.2026.113359. Epub 2026 May 9. PMID- 42125803 OWN - NLM STAT- MEDLINE DCOM- 20260917 LR - 20260923 IS - 1532-4303 (Electronic) IS - 0277-0903 (Linking) VI - 63 IP - 10 DP - 2026 Oct TI - Circulating IL-6 associates with a distinct pediatric asthma subtype and serves as a potential key predictor for risk stratification. PG - 1317-1328 LID - 10.1080/02770903.2026.2666086 [doi] AB - BACKGROUNDS: Childhood asthma is a heterogeneous disease wherein systemic inflammation, particularly involving nontype 2 cytokines such as interleukin-6 (IL-6), is not universally present and its clinical significance remains unclear. This cross-sectional observational study aimed to elucidate the association between circulating IL-6 levels and the phenotypic characteristics of pediatric asthma, and to explore the potential value of IL-6 as a predictive biomarker for asthma phenotypic risk stratification. METHODS: Plasma IL-6 levels were quantified in 105 newly diagnosed pediatric asthma patients (/=3.1 pg/mL, the 95th percentile of IL-6 levels in the healthy control group). Clinical, inflammatory, and lung function characteristics were compared between the two subgroups. Spearman's rank correlation analysis was conducted to explore the associations between cytokine levels and lung function/airway inflammation indices. Multivariate logistic regression analysis was performed to identify variables associated with asthma phenotypic characteristics, and subsequent feature selection was carried out using Least Absolute Shrinkage and Selection Operator (LASSO) regression with fivefold cross-validation. A priori sample size estimation and sex-stratified analyses were conducted, and all methods followed STROBE reporting guidelines. RESULTS: Compared with healthy controls, pediatric asthma patients had significantly elevated serum IgE levels, peripheral blood eosinophil counts, and plasma concentrations of IL-4, IL-6, and IL-12 (all p < 0.05). Among the asthma cohort, the "IL-6-high" subgroup (n = 20, 19.0%) had significantly higher body mass index (BMI) and plasma IL-12 levels relative to the "IL-6-normal" subgroup (n = 85). Sex-stratified analyses demonstrated consistent patterns of elevated IL-6-related airway inflammation and reduced lung function across male and female children, without significant subgroup divergence. Correlation analysis showed that plasma IL-4 levels were significantly negatively correlated with percent predicted forced expiratory volume in 1 s (FEV(1); r = -0.245, p = 0.025), and plasma IL-6 levels were significantly positively correlated with fractional exhaled nitric oxide (FeNO) levels (r = 0.214, p = 0.021). Multivariate logistic regression analysis identified asthma onset after 4 years of age, oral corticosteroid use, blood eosinophil count, FeNO level, and percent predicted FEV(1) as variables independently associated with asthma phenotypic characteristics. Notably, LASSO regression selected circulating IL-6 as the most prominent predictive biomarker for asthma phenotypic characteristics among all evaluated clinical, inflammatory, and lung function variables. A predictive nomogram incorporating key variables showed excellent discriminative performance in the training cohort (C-index = 0.85, 95%CI: 0.79-0.91) and was validated in an independent cohort (C-index = 0.82, 95%CI: 0.75-0.89). CONCLUSIONS: Elevated circulating IL-6 is a prominent feature associated with a distinct phenotypic subgroup of pediatric asthma, and is correlated with impaired lung function and increased airway inflammation in asthmatic children. These findings support the potential of IL-6 as a significant predictive biomarker for phenotypic risk stratification in pediatric asthma, and suggest its potential utility in phenotypic subtyping of asthmatic patients and as a promising therapeutic target for the IL-6-high pediatric asthma subgroup. All conclusions are interpreted cautiously, given the study's methodological limitations, and further large-cohort prospective validation is required. FAU - Liu, Yuyang AU - Liu Y AD - Department of pediatrics, Xi'an No.3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, China. FAU - Cheng, Lina AU - Cheng L AD - Department of Neonatology, Second Affiliated Hospital of Xi'an Medical College. FAU - Wang, Lu AU - Wang L AD - Department of pediatrics, Xi'an No.3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, China. LA - eng PT - Journal Article PT - Observational Study DEP - 20260601 PL - England TA - J Asthma JT - The Journal of asthma : official journal of the Association for the Care of Asthma JID - 8106454 RN - 0 (Interleukin-6) RN - 0 (Biomarkers) RN - 0 (IL6 protein, human) SB - IM MH - Humans MH - *Asthma/blood/physiopathology/immunology/diagnosis/classification MH - *Interleukin-6/blood MH - Male MH - Female MH - Child MH - Cross-Sectional Studies MH - Biomarkers/blood MH - Adolescent MH - Risk Assessment MH - Respiratory Function Tests MH - Child, Preschool MH - Phenotype OAB - What is already known on this topicChildhood asthma is a heterogeneous condition, and systemic inflammation is only present in a subset of patients. While type 2 inflammatory biomarkers such as IL-4 are often elevated in asthma, the role of nontype 2 cytokines such as IL-6 remains less clearly defined in pediatric asthma.What this study addsThis study reveals that elevated IL-6 is a key feature associated with a distinct subgroup of children with asthma and is significantly correlated with impaired lung function and airway inflammation. Furthermore, IL-6 was identified as a prominent potential predictive biomarker among all evaluated inflammatory and clinical variables via LASSO regression, with a validated predictive model showing good discriminative ability. This provides a basis for its potential application in pediatric asthma phenotypic subtyping and risk stratification.How this study might affect research, practice or policyThese findings suggest that IL-6 could serve as a potential predictive biomarker for asthma phenotypic sub-phenotyping and a promising therapeutic target for the IL-6-high pediatric asthma subgroup. The results may guide more personalized phenotypic stratification and treatment strategies for this specific subgroup and inform future research into anti-cytokine therapies for severe or corticosteroid-resistant non-type 2 asthma in children. OABL- eng OTO - NOTNLM OT - Asthma OT - LASSO regression OT - biomarker OT - interleukin-6 OT - pediatrics OT - phenotypic stratification EDAT- 2026/05/13 06:32 MHDA- 2026/09/17 05:35 CRDT- 2026/05/13 05:03 PHST- 2026/09/17 05:35 [medline] PHST- 2026/05/13 06:32 [pubmed] PHST- 2026/05/13 05:03 [entrez] AID - 10.1080/02770903.2026.2666086 [doi] PST - ppublish SO - J Asthma. 2026 Oct;63(10):1317-1328. doi: 10.1080/02770903.2026.2666086. Epub 2026 Jun 1. PMID- 42125621 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260513 LR - 20260926 IS - 1687-9740 (Print) IS - 1687-9759 (Electronic) IS - 1687-9740 (Linking) VI - 2026 DP - 2026 TI - The Double Burden: Understanding the Impact of Malnutrition on Childhood Cancer Outcomes in Resource-Limited Settings. PG - 8860996 LID - 10.1155/ijpe/8860996 [doi] LID - 8860996 AB - Childhood cancer disproportionately affects low- and middle-income countries (LMICs), where over 80% of cases occur, and malnutrition affects approximately 70% of pediatric oncology patients, substantially compromising treatment tolerance, immune function, and survival. This review integrates current evidence on the impact of malnutrition in LMICs, evaluates assessment methodologies and interventions, and identifies knowledge gaps that hinder optimal nutritional care. The A-B-C-D (anthropometric, biochemical, clinical, and dietary assessments) framework provides a systematic assessment, with mid-upper arm circumference and handgrip dynamometry offering practical evaluation in resource-limited settings. Prealbumin is the most sensitive early biochemical marker (54%-87% sensitivity vs. 7.4%-45.8% for albumin), and nutritional screening tools like SCAN demonstrate high validity for risk identification (> 80% sensitivity and specificity). Interventions such as ready-to-use therapeutic foods improved weight gain (77.8% vs. 64.2%) and reduced severe infections (10.6% vs. 31%) in trials. We emphasize a multidisciplinary approach and research priorities centered on standardized assessments, long-term effects of malnutrition, and culturally appropriate nutritional programs for LMICs. CI - Copyright (c) 2026 Michael Asare-Baah and Michael Lauzardo. International Journal of Pediatrics published by John Wiley & Sons Ltd. FAU - Asare-Baah, Michael AU - Asare-Baah M AUID- ORCID: 0000-0003-2409-2061 AD - Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA, ufl.edu. AD - Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA, ufl.edu. FAU - Lauzardo, Michael AU - Lauzardo M AUID- ORCID: 0000-0002-7096-4185 AD - Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA, ufl.edu. AD - Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA, ufl.edu. AD - Keira Grace Foundation, Gainesville, Florida, USA. LA - eng PT - Journal Article PT - Review DEP - 20260511 PL - United States TA - Int J Pediatr JT - International journal of pediatrics JID - 101517077 PMC - PMC13159538 OTO - NOTNLM OT - cancer outcomes OT - low- and middle-income countries OT - malnutrition OT - nutritional interventions OT - pediatric cancer OT - pediatric oncology COIS- The authors declare no conflicts of interest. EDAT- 2026/05/13 06:31 MHDA- 2026/05/13 06:32 PMCR- 2026/05/11 CRDT- 2026/05/13 04:46 PHST- 2025/02/12 00:00 [received] PHST- 2026/03/12 00:00 [revised] PHST- 2026/04/30 00:00 [accepted] PHST- 2026/05/13 06:32 [medline] PHST- 2026/05/13 06:31 [pubmed] PHST- 2026/05/13 04:46 [entrez] PHST- 2026/05/11 00:00 [pmc-release] AID - IJPE8860996 [pii] AID - 10.1155/ijpe/8860996 [doi] PST - epublish SO - Int J Pediatr. 2026 May 11;2026:8860996. doi: 10.1155/ijpe/8860996. eCollection 2026. PMID- 42125593 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260513 LR - 20260813 IS - 0970-0218 (Print) IS - 1998-3581 (Electronic) IS - 0970-0218 (Linking) VI - 51 IP - 2 DP - 2026 Mar-Apr TI - Development of a Microsoft Excel Calculator for Infant and Young Child Feeding Indicators. PG - 419-422 LID - 10.4103/ijcm.ijcm_610_24 [doi] AB - The accurate assessment of infant and young child feeding (IYCF) practices is critical for evaluating nutritional status and guiding public health interventions. The study was planned to develop and validate a Microsoft Excel-based IYCF calculator based on the World Health Organization (WHO)-United Nations Children's Fund (UNICEF) 2021 IYCF indicators for its accuracy, consistency, and user-friendliness. The tool incorporated calculations of all 16 essential indicators. Logical and conditional functions were used to automate calculations. Validations were done using simulated and real databases from urban slums. The IYCF Excel Calculator was developed using Microsoft Excel on Windows 11 and compatible with Excel 2016 or later. The tool accurately calculated IYCF indicators and was user-friendly for individuals with basic knowledge of Microsoft Excel. It reduced the time and complexity of calculations. The developed Excel-based IYCF calculator is an accurate, accessible, and freely available tool for researchers and practitioners for academic and non-commercial use. CI - Copyright: (c) 2026 Indian Journal of Community Medicine. FAU - Sabale, Rupali AU - Sabale R AD - Department of Community Medicine, Seth GS Medical College and KEM Hospital, Maharashtra, India. FAU - Velhal, Gajanan AU - Velhal G AD - Department of Community Medicine, Seth GS Medical College and KEM Hospital, Maharashtra, India. LA - eng PT - Journal Article DEP - 20260326 PL - India TA - Indian J Community Med JT - Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine JID - 9315574 PMC - PMC13160210 OTO - NOTNLM OT - Excel calculator OT - Infant and Young Child Feeding (IYCF) OT - WHO-UNICEF indicators OT - nutritional assessment OT - public health COIS- There are no conflicts of interest. EDAT- 2026/05/13 06:31 MHDA- 2026/05/13 06:32 PMCR- 2026/03/01 CRDT- 2026/05/13 04:46 PHST- 2024/08/25 00:00 [received] PHST- 2025/12/20 00:00 [accepted] PHST- 2026/05/13 06:32 [medline] PHST- 2026/05/13 06:31 [pubmed] PHST- 2026/05/13 04:46 [entrez] PHST- 2026/03/01 00:00 [pmc-release] AID - IJCM-51-419 [pii] AID - 10.4103/ijcm.ijcm_610_24 [doi] PST - ppublish SO - Indian J Community Med. 2026 Mar-Apr;51(2):419-422. doi: 10.4103/ijcm.ijcm_610_24. Epub 2026 Mar 26. PMID- 42124020 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260819 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 9 DP - 2026 Apr 30 TI - Toward Precision Obesity Pharmacotherapy: Using the Eating Behavior Phenotype Scale (EFCA) in Real-World Clinical Practice. LID - 10.3390/nu18091419 [doi] LID - 1419 AB - BACKGROUND: Obesity is a heterogeneous chronic disease in which eating behavior phenotypes may influence treatment response. Yet, anti-obesity medication (AOM) selection is still largely guided by anthropometric and metabolic parameters, with limited use of behavioral phenotyping in routine practice. We evaluated whether multidimensional eating behavior changes, measured by the Brazilian Eating Behavior Phenotype Scale (Escala de Fenotipos do Comportamento Alimentar, EFCA), differ across commonly used AOMs in a real-world cohort. METHODS: We conducted a retrospective, observational, real-world study in obesity outpatient care settings in Sao Paulo, Brazil. Adults with obesity (18-65 years) treated with a single principal AOM for 6 months and paired baseline/6-month follow-up EFCA and anthropometric data were included. Analyses focused on early responders (>/=5% total body weight loss at 3 months). Five AOM groups available in Brazil were analyzed: semaglutide (oral or subcutaneous), naltrexone/bupropion, sibutramine, topiramate, and tirzepatide. Outcomes included percent weight loss, EFCA total score, and five EFCA subscales (hedonic, emotional, compulsive, hyperphagic, disorganized). Within-medication behavioral changes were assessed using paired tests and standardized effect sizes (Cohen's dz, 95% CI), summarized in heatmap form. RESULTS: The analytical cohort comprised 66 early responders with paired EFCA assessments at baseline and 6 months. EFCA profiling revealed distinct behavioral response fingerprints across AOMs. Effect size mapping showed predominantly large behavioral effects (many dz >/= 0.8) in hedonic, emotional, hyperphagic, and compulsive domains. Strongest signals included emotional eating reductions with naltrexone/bupropion (dz 2.04), tirzepatide (dz 1.77), semaglutide (dz 1.52), and topiramate (dz 1.54); hedonic reductions with tirzepatide (dz 2.06), semaglutide (dz 1.55), and naltrexone/bupropion (dz 1.52); hyperphagic reductions with tirzepatide (dz 1.50) and semaglutide (dz 1.34); and compulsive reductions with topiramate (dz 1.41) and consistent effects across tirzepatide, semaglutide, and sibutramine ( approximately dz 0.95-0.96). Disorganized eating showed heterogeneous/attenuated responsiveness, from near-null with tirzepatide (dz 0.03) to large but imprecise effects in smaller groups (e.g., topiramate dz 1.24, wide CI). CONCLUSIONS: In this responder-enriched real-world cohort, AOMs showed distinct and reproducible EFCA behavioral signatures, supporting a clinically actionable phenotype-informed framework to prioritize, sequence, and monitor obesity pharmacotherapy beyond nonspecific weight reduction, while highlighting disorganization as a potential target for adjunctive behavioral strategies. FAU - Pineda-Wieselberg, Ronaldo Jose AU - Pineda-Wieselberg RJ AUID- ORCID: 0000-0001-7582-5179 AD - Discipline of Endocrinology, Santa Casa de Misericordia de Sao Paulo, Sao Paulo 01221-020, Brazil. FAU - Soares, Andressa Heimbecher AU - Soares AH AD - Discipline of Endocrinology, Santa Casa de Misericordia de Sao Paulo, Sao Paulo 01221-020, Brazil. FAU - Napoli, Thiago Fraga AU - Napoli TF AUID- ORCID: 0009-0007-6233-3408 AD - Discipline of Endocrinology, Santa Casa de Misericordia de Sao Paulo, Sao Paulo 01221-020, Brazil. FAU - Scalissi, Nilza Maria AU - Scalissi NM AD - Discipline of Endocrinology, Santa Casa de Misericordia de Sao Paulo, Sao Paulo 01221-020, Brazil. FAU - Salles, Joao Eduardo Nunes AU - Salles JEN AD - Discipline of Endocrinology, Santa Casa de Misericordia de Sao Paulo, Sao Paulo 01221-020, Brazil. LA - eng PT - Journal Article PT - Observational Study DEP - 20260430 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 53AXN4NNHX (Semaglutide) RN - 0 (Anti-Obesity Agents) RN - OYN3CCI6QE (Tirzepatide) RN - 0H73WJJ391 (Topiramate) RN - 01ZG3TPX31 (Bupropion) RN - WV5EC51866 (sibutramine) RN - 0 (Cyclobutanes) RN - 5S6W795CQM (Naltrexone) RN - 30237-26-4 (Fructose) SB - IM MH - Humans MH - *Obesity/drug therapy/psychology MH - Semaglutide MH - Adult MH - *Anti-Obesity Agents/therapeutic use MH - Middle Aged MH - Female MH - Male MH - *Feeding Behavior/drug effects MH - Phenotype MH - Retrospective Studies MH - Tirzepatide/therapeutic use MH - Topiramate/therapeutic use MH - Weight Loss/drug effects MH - Adolescent MH - Bupropion/therapeutic use MH - Brazil MH - Young Adult MH - Cyclobutanes/therapeutic use MH - Naltrexone/therapeutic use MH - *Precision Medicine/methods MH - Aged MH - Treatment Outcome MH - Fructose/analogs & derivatives/therapeutic use PMC - PMC13165399 OTO - NOTNLM OT - anti-obesity medications OT - behavioral scales OT - obesity OT - obesity phenotypes OT - precision medicine COIS- The authors declare no conflicts of interest for this paper. EDAT- 2026/05/13 06:32 MHDA- 2026/05/13 06:33 PMCR- 2026/04/30 CRDT- 2026/05/13 01:13 PHST- 2026/03/25 00:00 [received] PHST- 2026/04/16 00:00 [revised] PHST- 2026/04/22 00:00 [accepted] PHST- 2026/05/13 06:33 [medline] PHST- 2026/05/13 06:32 [pubmed] PHST- 2026/05/13 01:13 [entrez] PHST- 2026/04/30 00:00 [pmc-release] AID - nu18091419 [pii] AID - nutrients-18-01419 [pii] AID - 10.3390/nu18091419 [doi] PST - epublish SO - Nutrients. 2026 Apr 30;18(9):1419. doi: 10.3390/nu18091419. PMID- 42124016 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 9 DP - 2026 Apr 29 TI - Dietary and Oral Hygiene Behaviors Associated with Prevalent Caries Status in School-Aged Children of Northern Italy. LID - 10.3390/nu18091416 [doi] LID - 1416 AB - Background/Objectives: Unhealthy dietary behaviors and suboptimal oral hygiene practices remain common among Italian children, potentially affecting both nutritional and oral health. Dental caries, a preventable yet highly prevalent condition in pediatric populations, has a multifactorial etiology in which lifestyle factors play a key role. This study aimed to assess the prevalence of dental caries, dietary habits, and oral hygiene behaviors in school-aged children in Lombardy, and to identify factors associated with prevalent caries status. Methods: A cross-sectional study was conducted on 307 schoolchildren aged 9-10 years from ten schools in Northern Italy. Oral health status was evaluated through the plaque index and the DMFT/dmft index during school-based dental examinations. Dietary habits, lifestyle, and oral hygiene practices were collected through structured questionnaires. A mixed-effects logistic regression model was developed to explore potential associations between variables and prevalent caries status. Results: The dietary patterns, weight status, oral hygiene behaviors, and oral health conditions were generally consistent with the national data. Higher plaque index, skipping breakfast, consuming mid-morning snacks, and parental reports of previous caries experiences were retained in the final model. Internal validation suggested reasonable discriminatory ability overall, whereas calibration shows heterogeneity across schools. Conclusions: The findings highlight suboptimal dietary and oral hygiene behaviors among Lombardy schoolchildren and confirm their association with dental caries. Lifestyle-related factors, particularly oral hygiene practices and eating patterns, showed a relevant association with prevalent caries status in the analyzed sample. These results underscore the need for targeted preventive strategies integrating nutritional education and oral health promotion in pediatric populations. FAU - Troiani, Virginia AU - Troiani V AD - School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy. FAU - Ratti, Edoardo AU - Ratti E AUID- ORCID: 0009-0003-9818-795X AD - School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy. FAU - Gonnella, Daniel AU - Gonnella D AD - School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy. FAU - Panzeri, Maria Cristina AU - Panzeri MC AUID- ORCID: 0009-0000-4663-8542 AD - School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy. FAU - Palestini, Paola AU - Palestini P AUID- ORCID: 0000-0002-1045-8838 AD - School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy. AD - Master's Programme in Applied Food and Nutritional Sciences, School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy. FAU - Cazzaniga, Emanuela AU - Cazzaniga E AUID- ORCID: 0000-0002-5006-2280 AD - School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy. AD - Master's Programme in Applied Food and Nutritional Sciences, School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy. LA - eng PT - Journal Article DEP - 20260429 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Dental Caries/epidemiology MH - Child MH - Italy/epidemiology MH - *Oral Hygiene/statistics & numerical data MH - Female MH - Male MH - Cross-Sectional Studies MH - Prevalence MH - *Feeding Behavior MH - Oral Health MH - *Diet MH - Life Style MH - *Health Behavior PMC - PMC13164890 OTO - NOTNLM OT - children OT - dental caries OT - educational program OT - nutrition OT - oral health OT - prevention COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/05/13 06:31 MHDA- 2026/05/13 06:32 PMCR- 2026/04/29 CRDT- 2026/05/13 01:13 PHST- 2026/03/23 00:00 [received] PHST- 2026/04/23 00:00 [revised] PHST- 2026/04/28 00:00 [accepted] PHST- 2026/05/13 06:32 [medline] PHST- 2026/05/13 06:31 [pubmed] PHST- 2026/05/13 01:13 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - nu18091416 [pii] AID - nutrients-18-01416 [pii] AID - 10.3390/nu18091416 [doi] PST - epublish SO - Nutrients. 2026 Apr 29;18(9):1416. doi: 10.3390/nu18091416. PMID- 42123978 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 9 DP - 2026 Apr 27 TI - Weekday Sleep Duration and Perceived Restorative Sleep, but Not Dietary Intake, Are Associated with Lower Skin Autofluorescence in Japanese Early Adolescent Girls: A Cross-Sectional Study. LID - 10.3390/nu18091377 [doi] LID - 1377 AB - BACKGROUND: Advanced glycation end products (AGEs) accumulate in tissues with age and are associated with the risk of chronic diseases. However, evidence regarding lifestyle factors related to AGE accumulation in healthy adolescents is limited. The aim of this study was to explore dietary and lifestyle factors that may attenuate tissue AGE accumulation, using skin autofluorescence (SAF) as a noninvasive proxy marker, in healthy Japanese early adolescent girls. METHODS: This cross-sectional study included 315 first-year junior high school girls aged 12-13 years from a private school in Japan. SAF was measured on the volar forearm using an AGE Reader MU. Dietary intake was assessed using a validated brief diet history questionnaire (BDHQ-15y). Lifestyle factors, including weekday sleep duration, were assessed using a self-administered questionnaire. Health-related variables (including weight-loss dieting) were also collected. Associations between SAF and each factor were analyzed using generalized linear models and nonparametric tests, with multivariable adjustment for potential confounders. RESULTS: The mean SAF was 1.06 +/- 0.13 arbitrary units. No significant associations were observed between SAF and health-related characteristics, nutrient intakes, or major food-group intakes. Longer weekday sleep duration was significantly associated with lower SAF (p for trend = 0.019) and remained significant after multivariable adjustment (p for trend = 0.018). A similar association was observed for better perceived restorative sleep (p for trend = 0.033; adjusted p for trend = 0.048). CONCLUSIONS: In healthy early adolescent girls, longer weekday sleep duration and better perceived restorative sleep were associated with lower SAF, whereas dietary intake was not. Given the largely irreversible age-related accumulation of AGEs, promoting healthy sleep during adolescence may help attenuate AGE accumulation early in life and reduce long-term AGE-related disease risk. Prospective studies with more detailed dietary assessments are needed to clarify dietary influences and confirm temporality. FAU - Kohri, Toshiyuki AU - Kohri T AD - Department of Clinical Nutrition and Dietetics, Faculty of Clinical Nutrition and Dietetics, Konan Women's University, 6-2-23 Morikita-machi Higashinada-ku, Kobe 658-0001, Japan. FAU - Okamoto, Nozomi AU - Okamoto N AD - Department of School Psychology, Developmental Science and Health Education, Hyogo University of Teacher Education, 942-1 Shimokume, Kato 673-1494, Japan. FAU - Myojin, Chiho AU - Myojin C AD - Department of Food and Nutrition, Faculty of Agriculture, Kindai University, 3327-204 Nakamachi, Nara 631-8505, Japan. FAU - Kawanishi, Masako AU - Kawanishi M AD - Department of Food and Nutrition, Faculty of Agriculture, Kindai University, 3327-204 Nakamachi, Nara 631-8505, Japan. FAU - Makita, Yumika AU - Makita Y AD - Department of Food and Nutrition, Faculty of Agriculture, Kindai University, 3327-204 Nakamachi, Nara 631-8505, Japan. FAU - Yamamoto, Mako AU - Yamamoto M AD - Department of Clinical Nutrition and Dietetics, Faculty of Clinical Nutrition and Dietetics, Konan Women's University, 6-2-23 Morikita-machi Higashinada-ku, Kobe 658-0001, Japan. FAU - Higashine, Yuko AU - Higashine Y AD - Department of Clinical Nutrition and Dietetics, Faculty of Clinical Nutrition and Dietetics, Konan Women's University, 6-2-23 Morikita-machi Higashinada-ku, Kobe 658-0001, Japan. FAU - Nakamoto, Mariko AU - Nakamoto M AUID- ORCID: 0000-0001-7548-7499 AD - Department of Public Health and Applied Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan. LA - eng PT - Journal Article DEP - 20260427 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Glycation End Products, Advanced) SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Cross-Sectional Studies MH - *Diet MH - *Eating/physiology MH - *Glycation End Products, Advanced/metabolism MH - Japan MH - Life Style MH - Optical Imaging MH - *Skin/metabolism/diagnostic imaging MH - *Sleep/physiology MH - *Sleep Duration MH - Surveys and Questionnaires PMC - PMC13164999 OTO - NOTNLM OT - AGE OT - advanced glycation end product OT - dietary intake OT - early adolescence OT - perceived restorative sleep OT - skin autofluorescence OT - sleep duration COIS- The authors declare no conflicts of interest. EDAT- 2026/05/13 06:31 MHDA- 2026/05/13 06:32 PMCR- 2026/04/27 CRDT- 2026/05/13 01:13 PHST- 2026/03/13 00:00 [received] PHST- 2026/04/18 00:00 [revised] PHST- 2026/04/24 00:00 [accepted] PHST- 2026/05/13 06:32 [medline] PHST- 2026/05/13 06:31 [pubmed] PHST- 2026/05/13 01:13 [entrez] PHST- 2026/04/27 00:00 [pmc-release] AID - nu18091377 [pii] AID - nutrients-18-01377 [pii] AID - 10.3390/nu18091377 [doi] PST - epublish SO - Nutrients. 2026 Apr 27;18(9):1377. doi: 10.3390/nu18091377. PMID- 42123915 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 9 DP - 2026 Apr 22 TI - Pre-Diagnosis Dietary Pattern Differences in Australian Children with Inflammatory Bowel Disease: Exposure Across Ethnicities. LID - 10.3390/nu18091313 [doi] LID - 1313 AB - BACKGROUND/OBJECTIVES: The pre-diagnosis dietary intake in newly diagnosed multi-ethnic paediatric inflammatory bowel disease (PIBD) is not well understood. This study aimed to describe the pre-diagnosis diet and environmental factors in children with newly diagnosed PIBD attending a single Australian tertiary children's hospital. METHODS: A pilot cross-sectional study was conducted from February 2022 to February 2023 involving children with newly diagnosed PIBD. RESULTS: Of 56 children confirmed with PIBD, 54% had Crohn's disease (CD)-mean +/- SD age, 11.55 years +/- 2.84-and 46% had Ulcerative Colitis (UC)-11.50 years +/- 2.94 (45%, non-Caucasian). More Caucasians had an IBD family history (48.3% vs. 20%; p = 0.02 *). Non-Caucasian children demonstrated significantly lower mean serum vitamin D levels than Caucasian children (42.5 vs. 69 nmol/L; p 6 months. Dietary habits were assessed through a Mediterranean diet (MD) adherence validated index: the KIDMED. Associations between BF duration and KIDMED items were assessed using ANOVA, Chi-squared tests, and logistic regression models. RESULTS: Longer BF duration was associated with higher adherence to MD in both surveys. In 2019-2020, mean (SD) KIDMED scores were: no BF 6.5 (2.4), BF6 months 7.0 (2.4), (p<0.001); in 2022-2023, corresponding values were 6.2 (2.4), 6.4 (2.5), and 6.7 (2.4), (p<0.001). Logistic regression analyses showed that in both 2019-2020 and 2022-2023, BF>6 months was associated with lower odds of skipping breakfast and higher odds of consuming cereals at breakfast, vegetables, and rice or pasta. Several associations remained significant after adjustment for exclusive BF and parents' education, employment status, and age, although effect sizes were attenuated. CONCLUSIONS: Longer BF duration was associated with healthier dietary habits and higher adherence to the MD in children and adolescents, but these associations may reflect broader early-life family and socio-educational contexts rather than a direct causal effect of BF itself. CLINICAL TRIAL REGISTRATION: The trial was officially recorded in 2019 with the International Standard Randomized Controlled Trial (ISRCT), bearing the identification number 34,251,612 accessed on 08/08/2019 https//www.isrctn.com/ISRCTN34251612 (21). CI - (c) 2026. The Author(s). FAU - Garcia, Silvia AU - Garcia S AD - Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands-IUNICS, Palma de Mallorca, E-07122, Spain. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, Madrid, 28029, Spain. AD - Health Research Institute of Balearic Islands (IdISBa), Palma, Balearic Islands, E-07120, Spain. FAU - Rodenas-Munar, Marina AU - Rodenas-Munar M AD - Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands-IUNICS, Palma de Mallorca, E-07122, Spain. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, Madrid, 28029, Spain. AD - Health Research Institute of Balearic Islands (IdISBa), Palma, Balearic Islands, E-07120, Spain. FAU - Carmona-Rosado, Luis AU - Carmona-Rosado L AD - Public Health and Epidemiology Research Group, School of Medicine and Health Sciences, Universidad de Alcala, Alcala de Henares, Madrid, 28871, Spain. FAU - Sevilla-Sanchez, Marta AU - Sevilla-Sanchez M AD - Faculty of Sports Sciences and Physical Education, Universidade da Coruna, A Coruna, Spain. FAU - Gusi, Narcis AU - Gusi N AD - Physical Activity and Quality of Life Research Group (AFYCAV), Faculty of Sport Sciences, University of Extremadura, Caceres, Spain. AD - Instituto de Investigacion e Innovacion en el Deporte (INIDE), Caceres, 10003, Spain. FAU - Gomez, Santiago F AU - Gomez SF AD - Gasol Foundation Europe, Sant Boi de Llobregat, Barcelona, 08830, Spain. AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. AD - Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar Research Institute, Barcelona, Spain. AD - Nursing and Physiotherapy Department, University of Lleida, Lleida, Spain. FAU - Gonzalez-Gross, Marcela AU - Gonzalez-Gross M AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, Madrid, 28029, Spain. AD - ImFINE Research Group, Department of Health and Human Performance, Universidad Politecnica de Madrid, Madrid, Spain. FAU - Warnberg, Julia AU - Warnberg J AD - EpiPHAAN Research Group, Faculty of Health Sciences, Universidad de Malaga - Instituto de Investigacion Biomedica de Malaga (IBIMA Bionand), Malaga, Spain. FAU - Aznar, Susana AU - Aznar S AD - PAFS Research Group, Faculty of Sports Sciences, University of Castilla-La Mancha- Toledo Campus, Toledo, Spain. FAU - Pulgar, Susana AU - Pulgar S AD - Regional Unit of Sports Medicine of Principado de Asturias, Fundacion Deportiva Municipal de Aviles, Aviles, Spain. FAU - Serra-Majem, Lluis AU - Serra-Majem L AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, Madrid, 28029, Spain. AD - Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Las Palmas, Spain. AD - Preventive Medicine Service, Centro Hospitalario Universitario Insular Materno Infantil (CHUIMI), Canarian Health Service, Las Palmas, Spain. FAU - Martin-Oliveros, Adela AU - Martin-Oliveros A AD - Sociedad Espanola de Farmacia Clinica, Familiar y Comunitaria (SEFAC), Madrid, Spain. FAU - Marin-Cascales, Elena AU - Marin-Cascales E AD - UCAM Research Center for High Performance Sport, Universidad Catolica de Murcia, Murcia, 30107, Spain. AD - Faculty of Sport, Universidad Catolica de Murcia, Murcia, 30107, Spain. FAU - Fito, Montse AU - Fito M AD - Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar Institute for Medical Research, Barcelona, 08003, Spain. FAU - Diez, Julia AU - Diez J AD - Public Health and Epidemiology Research Group, School of Medicine and Health Sciences, Universidad de Alcala, Alcala de Henares, Madrid, 28871, Spain. FAU - Gonzalez-Valeiro, Miguel Angel AU - Gonzalez-Valeiro MA AD - Faculty of Sports Sciences and Physical Education, Universidade da Coruna, A Coruna, Spain. FAU - Gomez, Jesus Sanchez AU - Gomez JS AD - Physical Activity and Quality of Life Research Group (AFYCAV), Faculty of Sport Sciences, University of Extremadura, Caceres, Spain. AD - Instituto de Investigacion e Innovacion en el Deporte (INIDE), Caceres, 10003, Spain. FAU - Berruezo, Paula AU - Berruezo P AD - Public Health and Epidemiology Research Group, School of Medicine and Health Sciences, Universidad de Alcala, Alcala de Henares, Madrid, 28871, Spain. AD - Gasol Foundation Europe, Sant Boi de Llobregat, Barcelona, 08830, Spain. FAU - Zapico, Augusto G AU - Zapico AG AD - ImFINE Research Group, Department of Health and Human Performance, Universidad Politecnica de Madrid, Madrid, Spain. FAU - Oostrom-Rodriguez, Alvaro AU - Oostrom-Rodriguez A AD - EpiPHAAN Research Group, Faculty of Health Sciences, Universidad de Malaga - Instituto de Investigacion Biomedica de Malaga (IBIMA Bionand), Malaga, Spain. FAU - Martin-Moraleda, Evelyn AU - Martin-Moraleda E AD - PAFS Research Group, Faculty of Sports Sciences, University of Castilla-La Mancha- Toledo Campus, Toledo, Spain. FAU - Herrera-Ramos, Estefania AU - Herrera-Ramos E AD - Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Las Palmas, Spain. FAU - Mateos-Lardies, Ana AU - Mateos-Lardies A AD - Sociedad Espanola de Farmacia Clinica, Familiar y Comunitaria (SEFAC), Madrid, Spain. FAU - Alcaraz, Pedro E AU - Alcaraz PE AD - UCAM Research Center for High Performance Sport, Universidad Catolica de Murcia, Murcia, 30107, Spain. AD - Faculty of Sport, Universidad Catolica de Murcia, Murcia, 30107, Spain. FAU - Schroder, Helmut AU - Schroder H AD - Gasol Foundation Europe, Sant Boi de Llobregat, Barcelona, 08830, Spain. AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. AD - Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar Institute for Medical Research, Barcelona, 08003, Spain. FAU - Labayen, Idoia AU - Labayen I AD - ELIKOS Group, Department of Health Sciences, Institute for Sustainability and Food Chain Innovation (IS-FOOD), Public University of Navarre, Pamplona, Spain. FAU - Bouzas, Cristina AU - Bouzas C AD - Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands-IUNICS, Palma de Mallorca, E-07122, Spain. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, Madrid, 28029, Spain. AD - Health Research Institute of Balearic Islands (IdISBa), Palma, Balearic Islands, E-07120, Spain. FAU - Tur, Josep A AU - Tur JA AD - Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands-IUNICS, Palma de Mallorca, E-07122, Spain. pep.tur@uib.es. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, Madrid, 28029, Spain. pep.tur@uib.es. AD - Health Research Institute of Balearic Islands (IdISBa), Palma, Balearic Islands, E-07120, Spain. pep.tur@uib.es. AD - Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, IDISBA & CIBEROBN, Guillem Colom Bldg, Campus, Palma de Mallorca, E-07122, Spain. pep.tur@uib.es. LA - eng GR - N/A/Fundacion PROBITAS/ GR - N/A/Gasol Foundation/ GR - N/A/FC Barcelona Foundation/ GR - N/A/Banco Santander/ GR - N/A/IFA/ GR - N/A/Vienna/ GR - N/A/Fundacion Deporte Joven/ GR - N/A/European Regional Development Fund/ GR - CIBEROBN CB12/03/30038 and CIBERESP CB22/03/00058/Instituto de Salud Carlos III/ GR - FOLIUM, PRIMUS, SYNERGIA and LIBERI/IDISBA Grants/ GR - RED2022-134800-T/Ministerio de Ciencias e Innovacion, Spain/ PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20260512 PL - England TA - Int Breastfeed J JT - International breastfeeding journal JID - 101251562 SB - IM MH - Humans MH - Female MH - Child MH - Adolescent MH - Cross-Sectional Studies MH - *Breast Feeding/statistics & numerical data MH - Male MH - *Feeding Behavior MH - Diet, Mediterranean/statistics & numerical data MH - Time Factors MH - Surveys and Questionnaires PMC - PMC13340382 OTO - NOTNLM OT - Adolescents OT - Breastfeeding OT - Children OT - Dietary habits OT - Mediterranean diet OT - PASOS study COIS- Declarations. Institutional review board statement: The PASOS study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Ethics Committee of the Fundacio Sant Joan de Deu, Barcelona, Spain (ref. PIC 179 - 18; 17 December 2018). Informed consent: A signed informed consent form was obtained from the parent or legal guardian of each participant. Competing interests: The authors declare no competing interests. EDAT- 2026/05/13 06:31 MHDA- 2026/07/07 12:34 PMCR- 2026/05/12 CRDT- 2026/05/13 00:16 PHST- 2026/02/11 00:00 [received] PHST- 2026/05/05 00:00 [accepted] PHST- 2026/07/07 12:34 [medline] PHST- 2026/05/13 06:31 [pubmed] PHST- 2026/05/13 00:16 [entrez] PHST- 2026/05/12 00:00 [pmc-release] AID - 10.1186/s13006-026-00851-8 [pii] AID - 851 [pii] AID - 10.1186/s13006-026-00851-8 [doi] PST - epublish SO - Int Breastfeed J. 2026 May 12;21(1):66. doi: 10.1186/s13006-026-00851-8. PMID- 42119870 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1879-0003 (Electronic) IS - 0141-8130 (Linking) VI - 366 DP - 2026 Jun TI - Salecan improves diet-induced obesity and hepatic steatosis by regulating citrate cycle intermediates. PG - 152496 LID - S0141-8130(26)02423-2 [pii] LID - 10.1016/j.ijbiomac.2026.152496 [doi] AB - Salecan, a naturally occurring beta-glucan, represents an approved novel food ingredient in China. Although its numerous health benefits are acknowledged, the underlying mechanisms addressing obesity and hepatic steatosis remain uncertain. This investigation integrated a mouse model of diet-induced obesity with clinical observations in obese children to investigate the effects and underlying mechanisms of Salecan. In the animal model, obese mice were administered Salecan by gavage for 8 weeks. Salecan significantly promoted weight loss, reduced blood glucose levels, and improved insulin resistance in obese mice. It also reduced food intake without altering systemic energy metabolism, as evidenced by unchanged overall energy expenditure and maintained substrate utilization patterns. Notably, Salecan suppressed adipocyte hypertrophy within white adipose tissue and mitigated hepatic lipid accumulation. Metabolomic analysis revealed that Salecan markedly altered the serum metabolic profile of obese mice, particularly by elevating the levels of citrate cycle cycle intermediates, including alpha-ketoglutarate (AKG), fumarate, and malate. In the clinical component, serum AKG levels were significantly lower in obese children relative to healthy controls. They exhibited inverse correlations with body mass index, abdominal circumference, and triglyceride levels. The findings validate that Salecan mediates anti-obesity effects by regulating the citrate cycle in murine models, thereby strengthening its potential as a nutritional intervention for obesity and hepatic steatosis. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Liu, Kerong AU - Liu K AD - Department of Endocrinology, Affiliated Children's Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi, China. FAU - Chen, Sha AU - Chen S AD - Nanjing Medical University, Wuxi Medical Center, Wuxi, China. FAU - Cao, Minkai AU - Cao M AD - Department of Obstetrics and Gynecology, Affiliated Women's Hospital of Jiangnan University, Wuxi Maternity and Child Health Care Hospital, Wuxi, Jiangsu, China. FAU - Xu, Xu AU - Xu X AD - Department of Endocrinology, Affiliated Children's Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi, China. FAU - Jiang, Li AU - Jiang L AD - Department of Endocrinology, Affiliated Children's Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi, China. FAU - Liu, Zhenzhen AU - Liu Z AD - Department of Endocrinology, Affiliated Children's Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi, China. FAU - Lai, Jinxin AU - Lai J AD - Department of Medical Laboratory, Wuxi Eighth People's Hospital, Wuxi, China. FAU - Pan, Xiaoxiao AU - Pan X AD - Clinical Medical College, Jinzhou Medical University, The first People's hospital of Lianyungang, Lianyungang, Jiangsu, China. FAU - Zhang, Yu AU - Zhang Y AD - School of Food Science and Technology, Jiangnan University, Wuxi, China. FAU - Xu, Lulian AU - Xu L AD - Department of Endocrinology, Affiliated Children's Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi, China. Electronic address: xllgzw@126.com. FAU - Zhang, Le AU - Zhang L AD - Department of Neonatology, Affiliated Children's Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi, Jiangsu, China. Electronic address: zhangle@jiangnan.edu.cn. FAU - Gu, Ying AU - Gu Y AD - Department of Obstetrics and Gynecology, Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi, China. Electronic address: 13861870460@163.com. LA - eng PT - Journal Article DEP - 20260511 PL - Netherlands TA - Int J Biol Macromol JT - International journal of biological macromolecules JID - 7909578 RN - 0 (beta-Glucans) RN - 0 (salecan) SB - IM MH - Animals MH - *Obesity/drug therapy/metabolism/etiology/blood MH - Mice MH - *Fatty Liver/drug therapy/metabolism/etiology MH - *beta-Glucans/pharmacology/therapeutic use MH - Male MH - Humans MH - *Citric Acid Cycle/drug effects MH - Energy Metabolism/drug effects MH - Diet, High-Fat/adverse effects MH - Liver/drug effects/metabolism/pathology MH - Insulin Resistance MH - Disease Models, Animal MH - Mice, Inbred C57BL MH - Lipid Metabolism/drug effects OTO - NOTNLM OT - Citrate cycle OT - Hepatic steatosis OT - Obesity OT - Salecan OT - alpha-ketoglutarate COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/13 00:29 MHDA- 2026/05/29 15:44 CRDT- 2026/05/12 19:23 PHST- 2025/05/21 00:00 [received] PHST- 2026/01/10 00:00 [revised] PHST- 2026/05/10 00:00 [accepted] PHST- 2026/05/29 15:44 [medline] PHST- 2026/05/13 00:29 [pubmed] PHST- 2026/05/12 19:23 [entrez] AID - S0141-8130(26)02423-2 [pii] AID - 10.1016/j.ijbiomac.2026.152496 [doi] PST - ppublish SO - Int J Biol Macromol. 2026 Jun;366:152496. doi: 10.1016/j.ijbiomac.2026.152496. Epub 2026 May 11. PMID- 42118079 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260907 IS - 1878-2620 (Electronic) IS - 1499-4046 (Linking) VI - 58 IP - 9 DP - 2026 Sep TI - Exploring Perceptions and Practices Toward Sustainable Diets Among College Students in Lebanon. PG - 883-891 LID - S1499-4046(26)00093-X [pii] LID - 10.1016/j.jneb.2026.03.014 [doi] AB - OBJECTIVE: To assess college students' knowledge, attitudes, and practices (KAP) toward sustainable diets and their potential relationship with food security status, and to explore the associations between the KAP variables, adjusting for socioeconomic correlates. METHODS: A cross-sectional online survey was conducted among a convenience sample of 701 university students in Lebanon. The KAP of sustainable diets was assessed using previously validated tools and served as dependent variables, with socioeconomic characteristics, including food security status, as independent variables in multiple stepwise logistic regression models. RESULTS: Majority of students exhibited poor knowledge of sustainable diets (71.7%) and unsustainable practices (75.7%), whereas attitudes were predominantly positive (89.3%). Regression models showed that higher knowledge scores, not attitudes, were significantly associated with sustainable practices (P < 0.001). Other correlates of KAP included female sex, university major, financial aid, and food security status, among others (all P-values < 0.05). CONCLUSIONS AND IMPLICATIONS: This study can help inform educational strategies, public health programs, and food policies promoting sustainable diets among young adults. CI - Copyright (c) 2026 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved. FAU - Saade, Elyssa AU - Saade E AD - Food Security Program, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon. FAU - Kharroubi, Samer AU - Kharroubi S AD - Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon. FAU - Nasreddine, Lara AU - Nasreddine L AD - Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon. FAU - Zurayk, Rami AU - Zurayk R AD - Landscape Design and Ecosystem Management Department, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. FAU - Jomaa, Lamis AU - Jomaa L AD - Department of Nutrition, Gillings School of Global Public Health, the University of North Carolina at Chapel Hill, North Carolina, NC; Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon. Electronic address: lamisj@unc.edu. LA - eng PT - Journal Article DEP - 20260512 PL - United States TA - J Nutr Educ Behav JT - Journal of nutrition education and behavior JID - 101132622 SB - IM MH - Humans MH - Lebanon MH - Female MH - *Students/statistics & numerical data/psychology MH - *Health Knowledge, Attitudes, Practice MH - Cross-Sectional Studies MH - Male MH - Young Adult MH - Universities MH - Adult MH - Adolescent MH - *Diet/statistics & numerical data MH - Surveys and Questionnaires OTO - NOTNLM OT - college students OT - knowledge, attitudes, practices OT - sustainable diets COIS- CONFLICT OF INTEREST DISCLOSURE The authors have not stated any conflicts of interest. EDAT- 2026/05/12 12:35 MHDA- 2026/09/07 23:34 CRDT- 2026/05/12 10:27 PHST- 2025/07/10 00:00 [received] PHST- 2026/03/25 00:00 [revised] PHST- 2026/03/28 00:00 [accepted] PHST- 2026/09/07 23:34 [medline] PHST- 2026/05/12 12:35 [pubmed] PHST- 2026/05/12 10:27 [entrez] AID - S1499-4046(26)00093-X [pii] AID - 10.1016/j.jneb.2026.03.014 [doi] PST - ppublish SO - J Nutr Educ Behav. 2026 Sep;58(9):883-891. doi: 10.1016/j.jneb.2026.03.014. Epub 2026 May 12. PMID- 42117476 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1758-8111 (Electronic) IS - 1758-8103 (Linking) VI - 16 IP - 3 DP - 2026 Jun TI - Prediction of Cardiovascular Risk Using Machine Learning Based on Maximal Oxygen Consumption, Physical Fitness, and Anthropometry. PG - e70081 LID - 10.1111/cob.70081 [doi] AB - Cardiovascular risk factors in adolescence, often persist into adulthood, with low cardiorespiratory fitness representing one of the strongest predictors of future cardiovascular disease. We aimed to classify cardiovascular risk associated with low cardiorespiratory fitness in adolescents using machine learning models based on anthropometric and muscular fitness variables. A cross-sectional dataset of 7,852 adolescents aged 13-16 years was analysed. Predictors included body mass index, waist circumference, waist-to-height ratio, standing long jump, push-ups, and sit-ups, while the binary outcome was cardiovascular risk derived from maximal oxygen consumption (VO(2) (max)) cut-points. Data were standardised, class imbalance was addressed using Synthetic Minority Over-sampling TEchnique (SMOTE), and eight supervised classifiers were trained with stratified five-fold cross-validation and grid search. Ensemble tree-based methods outperformed kernel-based models. Gradient Boosting achieved the best balance between predictive performance (area under the curve-receiver operating curve [AUC-ROC] 0.716, F1-score 0.857, recall 0.760, accuracy 0.755), followed by Random Forest. SHapley Additive exPlanations (SHAP) analyses indicated that muscular fitness measures, particularly push-ups, sit-ups and standing long jump, contributed most to risk classification, whereas anthropometric indicators showed lower importance. These findings suggest that machine learning models built from school-based muscular fitness tests and basic anthropometry can discriminate adolescents at cardiovascular risk due to low cardiorespiratory fitness, offering a feasible, low-cost strategy to support early identification and targeted physical activity interventions. CI - (c) 2026 World Obesity Federation. FAU - Yanez-Sepulveda, Rodrigo AU - Yanez-Sepulveda R AUID- ORCID: 0000-0002-9311-6576 AD - Faculty Education and Humanities, Universidad Andres Bello, Vina del Mar, Chile. FAU - Olivares, Rodrigo AU - Olivares R AD - Escuela de Ingenieria Informatica, Universidad de Valparaiso, Valparaiso, Chile. FAU - Guzman-Munoz, Eduardo AU - Guzman-Munoz E AD - Escuela de Kinesiologia, Facultad de Salud, Universidad Santo Tomas, Talca, Chile. AD - Escuela de Pedagogia en Educacion Fisica, Facultad de Educacion, Universidad Autonoma de Chile, Talca, Chile. FAU - Concha-Cisternas, Yeny AU - Concha-Cisternas Y AD - Escuela de Kinesiologia, Facultad de Salud, Universidad Santo Tomas, Talca, Chile. AD - Vicerrectoria de Investigacion e Innovacion, Universidad Arturo Prat, Iquique, Chile. FAU - de Souza-Lima, Josivaldo AU - de Souza-Lima J AD - Faculty Education and Humanities, Universidad Andres Bello, Vina del Mar, Chile. FAU - Garcia-Carrillo, Exal AU - Garcia-Carrillo E AUID- ORCID: 0000-0001-6190-938X AD - Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca, Chile. AD - School of Education, Faculty of Human Sciences, Universidad Bernardo O'Higgins, Santiago, Chile. FAU - Paez-Herrera, Jacqueline AU - Paez-Herrera J AD - Grupo eFidac, Escuela de Educacion Fisica, Pontificia Universidad Catolica de Valparaiso, Valparaiso, Chile. FAU - Rojas-Valverde, Daniel AU - Rojas-Valverde D AD - Centro de Investigacion, Desarrollo e Innovacion en Salud y Deporte (CIDISAD), Escuela Ciencias del Movimiento Humano y Calidad e Vida (CIEMHCAVI), Universidad Nacional, Oriente, Costa Rica. FAU - Cortes-Roco, Guillermo AU - Cortes-Roco G AD - Facultad de Ciencias de la Vida, Universidad Vina del Mar, Vina del Mar, Chile. FAU - Clemente-Suarez, Vicente AU - Clemente-Suarez V AD - Grupo de Investigacion en Cultura, Educacion y Sociedad, Universidad de la Costa, Barranquilla, Colombia. AD - Universidad Europea de Madrid, Faculty of Sports Sciences, Tajo Street s/n, Madrid, Spain. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AUID- ORCID: 0000-0002-7412-7624 AD - School of Medicine, Universidad Espiritu Santo, Samborondon, Ecuador. AD - Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno, Chile. LA - eng PT - Journal Article PL - England TA - Clin Obes JT - Clinical obesity JID - 101560587 SB - IM MH - Humans MH - Adolescent MH - *Oxygen Consumption/physiology MH - *Physical Fitness/physiology MH - *Machine Learning MH - *Cardiovascular Diseases MH - Cross-Sectional Studies MH - Female MH - Heart Disease Risk Factors MH - Male MH - *Cardiorespiratory Fitness/physiology MH - Predictive Learning Models MH - *Anthropometry MH - Body Mass Index MH - Classification Algorithms MH - Prediction Algorithms MH - Random Forest MH - Waist Circumference MH - Risk Factors MH - Boosting Machine Learning Algorithms OTO - NOTNLM OT - cardiovascular diseases OT - exercise OT - machine learning OT - physical fitness EDAT- 2026/05/12 12:36 MHDA- 2026/05/12 12:37 CRDT- 2026/05/12 07:12 PHST- 2025/12/29 00:00 [revised] PHST- 2025/11/19 00:00 [received] PHST- 2026/04/09 00:00 [accepted] PHST- 2026/05/12 12:37 [medline] PHST- 2026/05/12 12:36 [pubmed] PHST- 2026/05/12 07:12 [entrez] AID - 10.1111/cob.70081 [doi] PST - ppublish SO - Clin Obes. 2026 Jun;16(3):e70081. doi: 10.1111/cob.70081. PMID- 42116062 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 May 11 TI - Criterion validity of a self-reported web-based data collection tool to measure daily school travel in middle school children. LID - 10.1186/s12889-026-27628-2 [doi] LID - 1517 AB - BACKGROUND: Various interventions have been developed with the intention to increase the amount of physical activity among children, including those promoting active school travel (AST). However, no gold standard currently exists for measuring different travel modes in AST. This study evaluates the criterion validity of a web-based data collection tool designed for children to self-report their school travel. PURPOSE: To assess the criterion validity of a web-based data collection tool for daily self-registration of commuting mode, time, and distance among middle school children in Sweden. METHODS: Thirty children (10-12 years old) from six schools in Falun, Sweden, were recruited using snowball sampling. The children self-reported their school travel data for one day, including travel mode, commuting time, and distance. Their reports were compared to a criterion standard based on direct observations. Spearman correlation and the Wilcoxon signed-rank test were used to analyze the accuracy of the self-reported data. RESULT: The web-based data collection tool demonstrated 100% agreement between self-reported and observed travel modes, with high correlations for commuting time and distance (r(s)=0.953-0.989, p < 0.001). The Wilcoxon signed rank test showed no significant differences between self-reported data and criterion standard (p = 0.243-0.903). CONCLUSION: The strong agreement between self-reported and observed travel data indicates high criterion validity, suggesting that the web-based data collection tool is a reliable method for middle school children to self-report their daily school travel. CI - (c) 2026. The Author(s). FAU - Andersson, Mathias AU - Andersson M AD - Department of Medical Sciences, School of Health and Welfare, Dalarna University, Falun, Sweden. maae@du.se. FAU - Tseli, Elena AU - Tseli E AD - Department of Medical Sciences, School of Health and Welfare, Dalarna University, Falun, Sweden. AD - Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Huddinge, Sweden. FAU - Lindqvist, Anna-Karin AU - Lindqvist AK AD - Department of Health, Education and Technology, Lulea University of Technology, Lulea, Sweden. FAU - Palstam, Annie AU - Palstam A AD - Department of Medical Sciences, School of Health and Welfare, Dalarna University, Falun, Sweden. AD - Sahlgrenska Academy, Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, University of Gothenburg, Gothenburg, Sweden. AD - Department of Occupational Therapy and Physiotherapy, Sahlgrenska University Hospital, Gothenburg, Sweden. LA - eng PT - Journal Article PT - Validation Study DEP - 20260511 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Child MH - Sweden MH - *Schools MH - *Internet MH - *Self Report MH - *Transportation/methods/statistics & numerical data MH - Female MH - Reproducibility of Results MH - Male MH - *Data Collection/methods PMC - PMC13159230 OTO - NOTNLM OT - Active school transport OT - Commuting OT - Measurement methods OT - Physical activity OT - Transportation COIS- Declarations. Ethics approval and consent to participate: The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Swedish Ethical Review Authority (Dnr. 2021-03783). During recruitment, it was emphasized that participation was voluntary and could be discontinued without giving reasons. The children received both oral and written information about the study. Written informed consent for participation and publication was obtained from the child and parent/legal guardian prior to participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/12 06:33 MHDA- 2026/05/12 06:34 PMCR- 2026/05/11 CRDT- 2026/05/12 00:38 PHST- 2025/12/16 00:00 [received] PHST- 2026/04/28 00:00 [accepted] PHST- 2026/05/12 06:34 [medline] PHST- 2026/05/12 06:33 [pubmed] PHST- 2026/05/12 00:38 [entrez] PHST- 2026/05/11 00:00 [pmc-release] AID - 10.1186/s12889-026-27628-2 [pii] AID - 27628 [pii] AID - 10.1186/s12889-026-27628-2 [doi] PST - epublish SO - BMC Public Health. 2026 May 11;26(1):1517. doi: 10.1186/s12889-026-27628-2. PMID- 42115837 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261010 IS - 1532-0987 (Electronic) IS - 0891-3668 (Print) IS - 0891-3668 (Linking) VI - 45 IP - 11 DP - 2026 Nov 1 TI - Risk of Infective Endocarditis in Pediatric Staphylococcal Bacteremia: A 20-Year Cohort Study. PG - 925-928 LID - 10.1097/INF.0000000000005257 [doi] AB - OBJECTIVE: The prevalence of Staphylococcus aureus endocarditis (SAE) in children with S. aureus bacteremia (SAB) varies widely and is generally lower than that in adults. This study aimed to determine the prevalence of SAE in pediatric patients with SAB and to identify the associated clinical risk factors. METHODS: This retrospective study included all children 0-18 years old diagnosed with SAB at a university hospital in Thailand between 2003 and 2023, identified using International Statistical Classification of Diseases and Related Health Problems 10th Revision codes. Endocarditis was defined using the modified Duke criteria, in accordance with the 2023 European Society of Cardiology guidelines for the management of endocarditis. RESULTS: Among the 171 children with SAB, 15 (8.8%) met the criteria for definite infective endocarditis. Methicillin-sensitive S. aureus was the predominant pathogen in both uncomplicated SAB and SAB complicated by endocarditis. Congenital heart disease was significantly associated with SAE ( P = 0.02). Additional risk factors included protein-energy malnutrition (PEM) ( P = 0.04) and more than 2 positive blood cultures ( P = 0.001), whereas immunocompromised status was associated with a reduced risk ( P < 0.001). Both SAB and SAE were associated with prolonged hospitalization and increased mortality. CONCLUSIONS: SAE occurred in 8.8% of pediatric SAB cases. Congenital heart disease, protein-energy malnutrition and persistent bacteremia were key predictors of SAE. In settings where echocardiography is not immediately accessible, these clinical risk factors can guide the early identification of high-risk patients and support decisions regarding monitoring intensity and timely referral. Larger prospective studies are needed to validate these associations and to facilitate the development of practical prediction tools for pediatric SAE. CI - Copyright (c) 2026 The Author(s). Published by Wolters Kluwer Health, LLC. FAU - Pakotiprapha, Apisara AU - Pakotiprapha A AD - From the Division of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. FAU - Chungsomprasong, Paweena AU - Chungsomprasong P AUID- ORCID: 0000-0003-0261-7007 FAU - Vijarnsorn, Chodchanok AU - Vijarnsorn C AUID- ORCID: 0000-0001-7124-2064 FAU - Chanthong, Prakul AU - Chanthong P AUID- ORCID: 0009-0006-1707-9378 FAU - Pacharapakornpong, Thita AU - Pacharapakornpong T AUID- ORCID: 0000-0001-9642-4614 FAU - Thammasate, Ploy AU - Thammasate P AUID- ORCID: 0009-0003-6155-0305 FAU - Srivichean, Auttapol AU - Srivichean A AUID- ORCID: 0009-0005-3925-8695 FAU - Durongpisitkul, Kritvikrom AU - Durongpisitkul K AUID- ORCID: 0000-0001-9295-516 FAU - Soongswang, Jarupim AU - Soongswang J AUID- ORCID: 0000-0001-7356-3881 LA - eng PT - Journal Article DEP - 20260512 PL - United States TA - Pediatr Infect Dis J JT - The Pediatric infectious disease journal JID - 8701858 SB - IM MH - Humans MH - Child MH - Child, Preschool MH - *Bacteremia/epidemiology/microbiology/complications MH - *Staphylococcal Infections/epidemiology/complications/microbiology MH - Female MH - Male MH - Infant MH - Retrospective Studies MH - Adolescent MH - Risk Factors MH - *Endocarditis, Bacterial/epidemiology/microbiology MH - Thailand/epidemiology MH - Infant, Newborn MH - Staphylococcus aureus MH - Prevalence PMC - PMC13649274 OTO - NOTNLM OT - bacteremia OT - infective endocarditis OT - pediatric COIS- The authors have no funding or conflicts of interest to disclose. EDAT- 2026/05/12 06:34 MHDA- 2026/10/09 05:30 PMCR- 2026/10/08 CRDT- 2026/05/12 00:03 PHST- 2026/04/01 00:00 [accepted] PHST- 2026/10/09 05:30 [medline] PHST- 2026/05/12 06:34 [pubmed] PHST- 2026/05/12 00:03 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - 00006454-990000000-01715 [pii] AID - PIDJ-264 [pii] AID - 10.1097/INF.0000000000005257 [doi] PST - ppublish SO - Pediatr Infect Dis J. 2026 Nov 1;45(11):925-928. doi: 10.1097/INF.0000000000005257. Epub 2026 May 12. PMID- 42115236 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 May 11 TI - Sports participation and obesity incidence in chinese adolescents: a 7-year prospective cohort study. LID - 10.1038/s41598-026-50212-y [doi] LID - 21526 AB - Adolescent obesity has risen to become a critical public health challenge around the world. According to the World Health Organization, roughly 340 million children and adolescents aged 5-19 were overweight or obese by 2016, representing a nearly sixfold increase since 1975. In China, rapid urbanization and shifting dietary patterns have accelerated this trend among school-age populations. Although physical activity is broadly considered protective against weight gain, longitudinal evidence that quantifies the magnitude of sports participation's effect on obesity incidence during adolescence remains sparse. We aimed to examine the dose-response relationship between sports participation intensity and seven-year obesity incidence among Chinese adolescents, and to identify subgroup-specific effect modification by sex, age, and baseline body mass index. We conducted a prospective cohort study drawing on data from the National Adolescent Health Surveillance System. A total of 89,532 initially non-obese Chinese adolescents aged 12-15 years were followed from 2016 to 2023. Sports participation intensity was assessed biannually through validated questionnaires, and obesity incidence was ascertained using WHO age- and sex-specific BMI criteria. Cox proportional hazards regression models were fitted with adjustment for demographic, socioeconomic, and time-varying behavioral confounders. Propensity score matching and marginal structural models served as supplementary analytical approaches to strengthen causal inference. Over 523,847 person-years of observation, 8,947 incident obesity cases were identified (17.1 per 1,000 person-years). Compared with minimal physical activity, high sports participation (>/= 300 min/week) was associated with a 58% lower obesity risk (HR = 0.42, 95% CI 0.37-0.48), and a clear dose-response gradient was observed. Moderate and low participation showed intermediate protective effects (HR = 0.61 and 0.73, respectively). These associations held up across multiple sensitivity analyses and were stronger among boys than girls. Sustained sports participation during adolescence substantially reduces obesity incidence in a dose-dependent manner. These findings offer compelling support for physical activity promotion policies and school-based interventions targeting this critical developmental period. This study was reported following the STROBE guidelines for observational studies. CI - (c) 2026. The Author(s). FAU - Qiu, Derun AU - Qiu D AD - College of P.E and Sports, Beijing Normal University, Beijing, Beijing, 100875, China. FAU - Dai, Chunmin AU - Dai C AD - International Football Education School, Jilin Agriculture University, Changchun, 130118, Jilin, China. dcm075213@163.com. LA - eng PT - Journal Article DEP - 20260511 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - Chinese people SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - Incidence MH - Prospective Studies MH - China/epidemiology MH - Child MH - *Sports MH - Body Mass Index MH - *Pediatric Obesity/epidemiology MH - *Exercise MH - Proportional Hazards Models MH - East Asian People PMC - PMC13351051 OTO - NOTNLM OT - Adolescent obesity OT - Cox proportional hazards model OT - Dose-response relationship OT - Physical activity OT - Prospective cohort study OT - Sports participation COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval and consent to participate: This study was approved by the Research Ethics Committee of Beijing Normal University (Reference Number: BNU-IRB-2016-037) and the Ethics Review Board of Jilin Agriculture University (Reference Number: JAU-ERB-2016-024). All procedures were conducted in accordance with the Declaration of Helsinki and relevant Chinese national regulations. Written informed consent was obtained from all participants and their legal guardians prior to enrollment. Consent for publication: All authors have reviewed and approved the final manuscript for publication. No identifiable individual participant data or images are included. All participants provided consent for their anonymized data to be used for research purposes and publication. EDAT- 2026/05/12 00:33 MHDA- 2026/07/11 04:10 PMCR- 2026/05/11 CRDT- 2026/05/11 23:16 PHST- 2025/11/16 00:00 [received] PHST- 2026/04/20 00:00 [accepted] PHST- 2026/07/11 04:10 [medline] PHST- 2026/05/12 00:33 [pubmed] PHST- 2026/05/11 23:16 [entrez] PHST- 2026/05/11 00:00 [pmc-release] AID - 10.1038/s41598-026-50212-y [pii] AID - 50212 [pii] AID - 10.1038/s41598-026-50212-y [doi] PST - epublish SO - Sci Rep. 2026 May 11;16(1):21526. doi: 10.1038/s41598-026-50212-y. PMID- 42114847 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260511 LR - 20260813 IS - 2005-3711 (Print) IS - 1598-7876 (Electronic) IS - 1225-8245 (Linking) VI - 69 IP - 3 DP - 2026 May TI - Wearable Technologies for Clinical Assessment and Monitoring in Pediatric Neurodevelopmental Disorders : A Narrative Review. PG - 361-370 LID - 10.3340/jkns.2026.0036 [doi] AB - Pediatric neurodevelopmental disorders (NDDs) as defined by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision : intellectual disabilities, communication disorders, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), specific learning disorder, and motor disorders together with closely associated pediatric neurological conditions such as cerebral palsy (CP) and epilepsy, present with symptom fluctuations and variable performance, making longitudinal assessment challenging. Conventional clinical scales, questionnaires, and caregiver diaries are largely subjective and offer limited temporal coverage. This review examines wearable technologies applicable to these conditions, focusing on measurable digital biomarkers and real-world clinical application. A narrative review was performed. Wearable technologies were categorized into motion trackers (accelerometers/gyroscopes, inertial measurement units [IMUs]), physiological monitors (photoplethysmography-derived heart rate and heart rate variability, and electrodermal activity), wearable electroencephalography (EEG)/brain sensors, smart glasses/cameras, and textile-based wearables. IMU and accelerometer based systems achieved posture and gait classification accuracies of approximately 85%, distinguished children with ADHD from controls with 80-90% accuracy, and detected stereotyped behaviors in children with ASD with sensitivities exceeding 90%. Wearable EEG demonstrated high performance for ASD classification (accuracy, 96%; sensitivity, 100%) and for automated sleep staging in epilepsy(accuracy, 80.8-83.5%), and also enabled seizure-related signal monitoring through detection of ictal fast activity. For tonic-clonic seizures, wearable devices achieved sensitivities of 89-94%, whereas tonic-seizure detection performance remains limited. Smartwatch vibrotactile stimulation reduced stereotyped behaviors and improved task performance, and wrist-worn biosignals enabled prediction of aggressive behavior approximately three minutes before onset. Augmented reality based smart glasses supported social-communication coaching in children with ASD. In children with CP, smart-shoe systems classified daily activities with high accuracy and quantified gait asymmetry. Wearables enable objective and continuous assessment of symptoms and behaviors in children with NDDs and related pediatric neurological conditions across real-world environments and are expanding toward personalized intervention. Remaining challenges include integration into clinical workflows (electronic medical record [EMR] linkage, clinician-friendly data summarisation, and reimbursement pathways), ethical and privacy considerations, and standardisation of validation protocols. FAU - Lee, Eun Jae AU - Lee EJ AD - Division of Pediatric Neurology, Department of Pediatrics, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul, Korea. AD - Department of Community Health Nursing, Ewha Womans University, Seoul, Korea. FAU - Kim, Woojoong AU - Kim W AD - Division of Pediatric Neurology, Department of Pediatrics, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul, Korea. LA - eng PT - Journal Article DEP - 20260430 PL - Korea (South) TA - J Korean Neurosurg Soc JT - Journal of Korean Neurosurgical Society JID - 101467054 PMC - PMC13172776 OTO - NOTNLM OT - Biomarkers OT - Neurodevelopmental disorders OT - Remote patient monitoring OT - Wearable electronic devices COIS- Conflicts of interest No potential conflict of interest relevant to this article was reported. EDAT- 2026/05/12 00:32 MHDA- 2026/05/12 00:33 PMCR- 2026/05/01 CRDT- 2026/05/11 20:31 PHST- 2026/02/04 00:00 [received] PHST- 2026/04/26 00:00 [accepted] PHST- 2026/05/12 00:33 [medline] PHST- 2026/05/12 00:32 [pubmed] PHST- 2026/05/11 20:31 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - jkns.2026.0036 [pii] AID - jkns-2026-0036 [pii] AID - 10.3340/jkns.2026.0036 [doi] PST - ppublish SO - J Korean Neurosurg Soc. 2026 May;69(3):361-370. doi: 10.3340/jkns.2026.0036. Epub 2026 Apr 30. PMID- 42114675 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 74 DP - 2026 Aug TI - Assessing the validity of a portable indirect calorimetry device in a pediatric sample. PG - 103320 LID - S2405-4577(26)00416-X [pii] LID - 10.1016/j.clnesp.2026.103320 [doi] AB - BACKGROUND & AIMS: Accurate and scalable tools to measure metabolic markers, such as resting energy expenditure (REE) and respiratory quotient (RQ) are essential for the success of personalized nutrition and weight management programs. These measures are particularly relevant for children, as their metabolism and energy needs fluctuate widely during development. Predictive equations are limited due to their poor precision at the individual level, particularly in children. While the Douglas Bag method remains the gold standard for measuring REE and gas exchange, it is impractical for routine pediatric use due to high monetary cost, long measurement time, and expertise requirements. The Breezing Med device could potentially serve as a portable, non-invasive alternative for accurately assessing metabolism, but it has not been validated in children. METHODS: The purpose of this study was to validate the Breezing Med device, a handheld, portable indirect calorimetry tool, against the gold-standard Douglas Bag method for measuring REE and gas exchange parameters in a pediatric sample. Nineteen children (mean age: 10.5 +/- 3.7 years; range: 5-17 years) completed resting, fasted testing with the Breezing Med and Douglas Bag system. Agreement was assessed using concordance correlation coefficients (CCC), bias analyses, and Bland-Altman plots. Root mean square error (RMSE) and +/-10% accuracy thresholds were also calculated to evaluate overall prediction error. Results were also compared to predictive energy expenditure equations that are commonly used for pediatric populations. RESULTS: Breezing Med demonstrated good agreement with Douglas Bag for REE (CCC = 0.88; bias correction factor = 0.93), although it systematically overestimated REE by 126.8 kcal/day (9.8%) and REE/kg by 4.5 kcal/kg/day (12.0%). Compared to the Douglas Bag, the Breezing Med overestimated VO(2) by 13.8%, while differences in VCO(2) were negligible (mean bias = -1.1 mL/min, -0.6%). In contrast, predictive equations showed smaller mean bias but greater variability, lower CCC values, and weaker overall agreement compared to Breezing Med. Breezing Med demonstrated lower overall prediction error than predictive equations. RQ showed negative bias (mean difference = -0.10) with poor categorical agreement (kappa(w) = 0.12). CONCLUSIONS: Breezing Med provides a scalable, non-invasive approach for measuring REE and gas exchange in children but appears to systematically overestimate VO(2) magnitudes. This led to overestimations of REE and poor RQ agreement in our sample. These findings suggest the device demonstrates good precision but reduced accuracy relative to the Douglas Bag method. Software calibration or correction factors would need to be developed to correct these overestimates before widespread use in clinical settings can be recommended. Testing on a larger and more diverse pediatric sample would be needed to develop and validate appropriate correction factors. With appropriate calibration, Breezing Med holds promise as a useful and accessible tool for individualized metabolic assessment, particularly in settings where traditional gold-standard methods are impractical. CI - Copyright (c) 2026 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. FAU - Neuwald, Nicholas V AU - Neuwald NV AD - Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA; Center for Ingestive Behaviors, University at Buffalo, Buffalo, NY, USA. Electronic address: nneuwald@buffalo.edu. FAU - Temple, Jennifer L AU - Temple JL AD - Center for Ingestive Behaviors, University at Buffalo, Buffalo, NY, USA; Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, NY, USA. FAU - Epstein, Leonard H AU - Epstein LH AD - Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA; Center for Ingestive Behaviors, University at Buffalo, Buffalo, NY, USA. LA - eng PT - Journal Article PT - Validation Study DEP - 20260509 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM MH - Humans MH - *Calorimetry, Indirect/instrumentation/methods MH - Child MH - Child, Preschool MH - Adolescent MH - Reproducibility of Results MH - Female MH - Male MH - Energy Metabolism MH - Basal Metabolism OTO - NOTNLM OT - Breezing Med OT - Indirect calorimetry OT - Pediatric metabolism OT - Point of care OT - Respiratory quotient OT - Resting energy expenditure COIS- Conflict of interest The authors declare no conflicts of interest related to this work. EDAT- 2026/05/12 00:33 MHDA- 2026/06/27 00:56 CRDT- 2026/05/11 19:14 PHST- 2025/10/16 00:00 [received] PHST- 2026/04/13 00:00 [revised] PHST- 2026/05/01 00:00 [accepted] PHST- 2026/06/27 00:56 [medline] PHST- 2026/05/12 00:33 [pubmed] PHST- 2026/05/11 19:14 [entrez] AID - S2405-4577(26)00416-X [pii] AID - 10.1016/j.clnesp.2026.103320 [doi] PST - ppublish SO - Clin Nutr ESPEN. 2026 Aug;74:103320. doi: 10.1016/j.clnesp.2026.103320. Epub 2026 May 9. PMID- 42113963 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260511 LR - 20260813 IS - 2561-6722 (Electronic) IS - 2561-6722 (Linking) VI - 9 DP - 2026 May 11 TI - Usability and Acceptability of a Digital Health App to Support Infant Feeding and Lifestyle Behaviors: Mixed Methods Pilot Study. PG - e86139 LID - 10.2196/86139 [doi] LID - e86139 AB - BACKGROUND: Childhood obesity is a global health concern with long-term cardiometabolic and psychosocial consequences. Establishing healthy feeding and lifestyle behaviors from infancy is critical to population health efforts with a life course perspective. Recently, digital health applications have gained traction in reaching out to parents and promoting healthy feeding behaviors. OBJECTIVE: The aim of this study was to evaluate the usability and acceptability of the Feeding, Lifestyle, Activity Goals app in providing parents with evidence-based guidance and tailored advice to promote healthier eating behaviors and lifestyle habits among infants. METHODS: We conducted a mixed methods pilot study among parents of infants aged 0 to 24 months recruited from a tertiary maternity and children's hospital in Singapore. Participants used the digital health app for 7 days. Usability was assessed using the validated System Usability Scale (score range 0-100, with >/=70 indicating acceptable usability). Acceptability was explored via open-ended questionnaires on satisfaction, relevance, and user experience, with qualitative data analyzed thematically by 2 independent coders to ensure rigor. RESULTS: A total of 26 parents of infants aged 3 weeks to 23 months completed the study. The app demonstrated good usability, with a mean System Usability Scale score of 71.3 (SD 11.0). Parents valued its role in organizing infant care; promoting self-reflection on parenting practices; and providing personalized, evidence-based recommendations. These benefits were particularly appreciated by first-time parents and those with multiple caregiving responsibilities. Challenges included an unintuitive user interface, high manual data entry burden, and advisory content that was occasionally overly general or text heavy. These insights highlight clear priorities for onward efforts in optimization. CONCLUSIONS: Results of our mixed methods evaluation indicate that our digital health app demonstrated good usability and acceptability among parents of infants. Targeted refinements to the interface, data entry processes, and content delivery are warranted before large-scale evaluation to determine its impact on early-life health behaviors and obesity prevention. CI - (c) Madhumitha Ayyappan, Nowel Tan, Sarithra Jayasekaran, Chee Wai Ku, Chengsi Ong, Chua Mei Chien, Jerry Kok Yen Chan, Fabian Yap, See Ling Loy, Daniel Chan. Originally published in JMIR Pediatrics and Parenting (https://pediatrics.jmir.org). FAU - Ayyappan, Madhumitha AU - Ayyappan M AUID- ORCID: 0009-0006-7474-3028 AD - Duke-NUS Medical School, 8 College Rd, Singapore, 169857, Singapore, 65 93871908. FAU - Tan, Nowel AU - Tan N AUID- ORCID: 0009-0004-3894-344X AD - Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Jayasekaran, Sarithra AU - Jayasekaran S AUID- ORCID: 0009-0007-9889-1639 AD - Endocrinology Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Ku, Chee Wai AU - Ku CW AUID- ORCID: 0000-0003-3719-3005 AD - Duke-NUS Medical School, 8 College Rd, Singapore, 169857, Singapore, 65 93871908. AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, Singapore. AD - SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Ong, Chengsi AU - Ong C AUID- ORCID: 0000-0002-5093-2848 AD - Duke-NUS Medical School, 8 College Rd, Singapore, 169857, Singapore, 65 93871908. AD - Department of Nutrition and Dietetics, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Mei Chien, Chua AU - Mei Chien C AUID- ORCID: 0000-0002-7471-751X AD - Duke-NUS Medical School, 8 College Rd, Singapore, 169857, Singapore, 65 93871908. AD - Department of Neonatology, KK Women's and Children's Hospital, Singapore, Singapore. AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. FAU - Chan, Jerry Kok Yen AU - Chan JKY AUID- ORCID: 0000-0002-0246-2159 AD - Duke-NUS Medical School, 8 College Rd, Singapore, 169857, Singapore, 65 93871908. AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, Singapore. AD - SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Yap, Fabian AU - Yap F AUID- ORCID: 0000-0003-1083-7958 AD - Duke-NUS Medical School, 8 College Rd, Singapore, 169857, Singapore, 65 93871908. AD - Endocrinology Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore. AD - SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore, Singapore. AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. FAU - Loy, See Ling AU - Loy SL AUID- ORCID: 0000-0002-9205-5580 AD - Duke-NUS Medical School, 8 College Rd, Singapore, 169857, Singapore, 65 93871908. AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, Singapore. AD - SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Chan, Daniel AU - Chan D AUID- ORCID: 0000-0001-8191-5330 AD - Duke-NUS Medical School, 8 College Rd, Singapore, 169857, Singapore, 65 93871908. AD - Endocrinology Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore. AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. LA - eng PT - Journal Article DEP - 20260511 PL - Canada TA - JMIR Pediatr Parent JT - JMIR pediatrics and parenting JID - 101727244 PMC - PMC13160257 OTO - NOTNLM OT - acceptability OT - childhood obesity OT - early-life behaviors OT - infant feeding OT - mHealth OT - mobile apps OT - mobile health OT - obesity prevention OT - usability COIS- Conflicts of Interest: None declared. EDAT- 2026/05/11 18:32 MHDA- 2026/05/11 18:33 PMCR- 2026/05/11 CRDT- 2026/05/11 14:52 PHST- 2025/10/19 00:00 [received] PHST- 2026/04/11 00:00 [revised] PHST- 2026/04/13 00:00 [accepted] PHST- 2026/05/11 18:33 [medline] PHST- 2026/05/11 18:32 [pubmed] PHST- 2026/05/11 14:52 [entrez] PHST- 2026/05/11 00:00 [pmc-release] AID - v9i1e86139 [pii] AID - 86139 [pii] AID - 10.2196/86139 [doi] PST - epublish SO - JMIR Pediatr Parent. 2026 May 11;9:e86139. doi: 10.2196/86139. PMID- 42111817 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - The association of BMI, lifestyle behaviors, and knowledge of acute cholecystitis of adults: a cross-sectional study. PG - e21172 LID - 10.7717/peerj.21172 [doi] LID - e21172 AB - OBJECTIVE: Acute cholecystitis is a common biliary disorder with rising prevalence in Saudi Arabia, yet the relationship between body mass index (BMI), lifestyle behaviors, and public knowledge about the condition remains underexplored. This study assessed these associations to inform preventive and educational strategies. METHODS: A cross-sectional survey was conducted among 385 adults aged 18-80 years residing in Abha, Saudi Arabia, who voluntarily agreed to participate. Data were collected using a validated, self-administered online questionnaire covering socio-demographics, lifestyle behaviors, and four knowledge domains. Knowledge levels were categorized using a validated scoring system in which correct responses were summed and classified as low, moderate, or high based on predetermined cutoff scores. BMI was calculated from self-reported height and weight. RESULTS: Participants were predominantly female (76.1%), The mean age of participants was 33 +/- 14 years, and their mean BMI was 27.5 +/- 5 kg/m(2), indicating a generally young sample with a high prevalence of overweight and obesity. Knowledge was moderate in most respondents (53.2%), high in 43.9%, and low in 2.9%. Risk factor and symptom knowledge scored highest (mean = 2.40/3), while dietary risk knowledge scored lowest (mean = 2.13/3). BMI correlated positively with lifestyle score (r = 0.310, p = 0.041), dietary risk knowledge (r = 0.280, p = 0.047), and risk factor knowledge (r = 0.360, p = 0.008). Lifestyle scores correlated significantly with all knowledge domains (r = 0.390-0.450, p < 0.01). Although the correlation coefficients were modest (r /= 8 years old. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/09 00:34 MHDA- 2026/05/09 00:35 PMCR- 2026/05/08 CRDT- 2026/05/08 23:54 PHST- 2025/10/29 00:00 [received] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/05/09 00:35 [medline] PHST- 2026/05/09 00:34 [pubmed] PHST- 2026/05/08 23:54 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - 10.1186/s40337-026-01589-8 [pii] AID - 1589 [pii] AID - 10.1186/s40337-026-01589-8 [doi] PST - epublish SO - J Eat Disord. 2026 May 8;14(1):108. doi: 10.1186/s40337-026-01589-8. PMID- 42104437 OWN - NLM STAT- MEDLINE DCOM- 20260702 LR - 20260813 IS - 1868-7083 (Electronic) IS - 1868-7075 (Print) IS - 1868-7075 (Linking) VI - 18 IP - 1 DP - 2026 May 8 TI - Body mass index, physical activity, and epigenetic aging: a cross-population study. LID - 10.1186/s13148-026-02149-2 [doi] LID - 127 AB - BACKGROUND: Observational studies have suggested that body mass index (BMI) is associated with accelerated epigenetic aging; however, the age at which this association begins and the duration of its effects have not been fully established. This study evaluated the effects of BMI and physical activity on epigenetic aging from early life to adulthood. METHODS: We integrated multi-source data from populations of different racial backgrounds, including genome-wide association study (GWAS) data, the National Health and Nutrition Examination Survey (NHANES), clinical visceral adipose tissue, and blood samples from obese and physically active populations. Specifically, Mendelian randomization (MR) analysis was used to infer the causal relationship between early-life BMI and epigenetic age acceleration and to identify potential mediators. NHANES data were then analyzed to validate this association at the population level. Finally, biomarkers in blood and adipose tissue were examined to assess whether physical activity is associated with reduced aging-related signatures. RESULTS: The Mendelian randomization analyses indicated that high early-life BMI was causally associated with accelerated epigenetic aging across multiple epigenetic clocks, with beta ranging from 0.231 to 0.506; similar associations were also observed for childhood obesity, with beta ranging from 0.139 to 0.231. Physical activity was identified as an important mediator that attenuated epigenetic aging acceleration, with mediation effects accounting for 10.70% to 16.22%. Analysis of the NHANES dataset further confirmed that epigenetic age acceleration increases progressively with increasing BMI: [25 /= 40: beta = 4.64, 95% CI (4.30, 4.99)]. Subgroup analysis showed that, at the same BMI level, female exhibited more severe PhenoAA acceleration than male. Validation using multi-tissue samples showed that obesity accelerates DNA damage and significantly upregulates genes involved in cell cycle regulation. Physical activity significantly inhibited the upregulation of aging-related genes and reduced oxidative stress. CONCLUSION: BMI is strongly associated with accelerated epigenetic aging. This association is evident in children with obesity, becomes stronger with higher BMI, and is also observed in adults, whereas physical activity may partially attenuate this process. Trial registration Name of the registry: China-Japan Friendship Hospital National Integrated Chinese and Western Medicine Medical Center. Unique identifying number or registration ID: NCT06452303. Hyperlink to your specific registration (must be publicly accessible and will be checked): https://www.centerwatch.com/clinical-trials/listings/NCT06452303/the-patient-cohort-for-bariatric-surgery . CI - (c) 2026. The Author(s). FAU - Zhou, Bojun AU - Zhou B AD - Department of Exercise Physiology, Beijing Sport University, Beijing, 100091, Beijing, China. AD - Department of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, 100029, Beijing, China. FAU - Wu, Dongzhe AU - Wu D AD - Department of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, 100029, Beijing, China. FAU - Chen, Shuting AU - Chen S AD - Department of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, 100029, Beijing, China. AD - School of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing, 100091, Beijing, China. FAU - Zhang, Shiyan AU - Zhang S AD - Department of Exercise Physiology, Beijing Sport University, Beijing, 100091, Beijing, China. AD - Department of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, 100029, Beijing, China. FAU - Ge, Xiaochuan AU - Ge X AD - Department of Exercise Physiology, Beijing Sport University, Beijing, 100091, Beijing, China. AD - Department of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, 100029, Beijing, China. FAU - Li, Jiaming AU - Li J AD - Department of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, 100029, Beijing, China. FAU - Zhu, Lianghao AU - Zhu L AD - Key Laboratory of Competitive Sport Psychological and Psychological Regulation, Tianjin University of Sport, Tianjin, 300211, Tianjin, China. FAU - Zhou, Shijie AU - Zhou S AD - School of Laboratory Medicine and School of Biological Engineering, Hangzhou Medical College, Zhejiang, 310059, Hangzhou, China. FAU - Chang, Ninghao AU - Chang N AD - The High School Affiliated to Beijing Normal University, Beijing, 100051, Beijing, China. FAU - Zhou, Biao AU - Zhou B AD - Department of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, 100029, Beijing, China. zhoubiao327@163.com. FAU - Zhang, Lei AU - Zhang L AD - Department of Oncology, Sinopharm Tongmei General Hospital, Shanxi, 037000, Datong, China. zhanglei412625@163.com. FAU - Meng, Hua AU - Meng H AD - Department of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, 100029, Beijing, China. menghuade@hotmail.com. LA - eng SI - ClinicalTrials.gov/NCT06452303 GR - 82470857/National Natural Science Foundation of China/ GR - 7242125/Beijing Natural Science Foundation/ PT - Journal Article PT - Observational Study DEP - 20260508 PL - Germany TA - Clin Epigenetics JT - Clinical epigenetics JID - 101516977 SB - IM MH - Adult MH - Child MH - Female MH - Humans MH - Male MH - Middle Aged MH - *Aging/genetics MH - *Body Mass Index MH - DNA Methylation MH - *Epigenesis, Genetic MH - *Exercise/physiology MH - Genome-Wide Association Study/methods MH - Mendelian Randomization Analysis/methods MH - Nutrition Surveys MH - Obesity/genetics PMC - PMC13326471 OTO - NOTNLM OT - Aging clock OT - Body mass index OT - Epigenetics OT - Physical activity COIS- Declarations. Ethics approval and consent to participate: All the cohorts and samples involved in the study adhered to national and international guidelines, including the Deontological Code and the Declaration of Helsinki, and complied with current personal data protection regulations. The research using publicly available data was approved by the relevant authorities, with all participants having provided informed consent. For the multi-biomarker studies, ethical approval was obtained from China-Japan Friendship Hospital and Beijing Sport University, and all participants signed informed consent forms (Ethics approval number: 2021-112-K70). Consent for publication: Written informed consent for publication was obtained from every patient; for minors, consent was secured from their parents or legal guardians. Competing interests: The authors declare no competing interests. EDAT- 2026/05/09 00:33 MHDA- 2026/07/02 06:40 PMCR- 2026/05/08 CRDT- 2026/05/08 23:52 PHST- 2026/01/24 00:00 [received] PHST- 2026/04/22 00:00 [accepted] PHST- 2026/07/02 06:40 [medline] PHST- 2026/05/09 00:33 [pubmed] PHST- 2026/05/08 23:52 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - 10.1186/s13148-026-02149-2 [pii] AID - 2149 [pii] AID - 10.1186/s13148-026-02149-2 [doi] PST - epublish SO - Clin Epigenetics. 2026 May 8;18(1):127. doi: 10.1186/s13148-026-02149-2. PMID- 42102665 OWN - NLM STAT- MEDLINE DCOM- 20260527 LR - 20260528 IS - 1879-0739 (Electronic) IS - 0271-5317 (Linking) VI - 150 DP - 2026 Jun TI - Moderate coffee intake does not significantly affect short-term bioelectrical impedance measurements in healthy women. PG - 62-71 LID - S0271-5317(26)00041-2 [pii] LID - 10.1016/j.nutres.2026.04.002 [doi] AB - Bioelectrical impedance analysis (BIA) is a widely used, noninvasive method for assessing body composition. However, its sensitivity to acute changes in water consumption and coffee intake raises concerns about measurement reliability. This study hypothesized that the short-term consumption of 200 mL caffeinated or decaffeinated coffee would result in measurable changes in BIA-derived body composition parameters compared to water intake. Twenty-seven healthy female participants (aged 18-35 years; body mass index 18.5-29.9 kg/m(2)) were randomly assigned to one of three groups: caffeinated coffee, decaffeinated coffee, or water (n = 9 per group). After all groups consumed 200 mL of the assigned beverage, BIA measurements were performed at baseline, 30, 60, 90, and 120 minutes using the InBody 270 analyzer. Nonparametric tests (Kruskal-Wallis, Friedman) and Quade ANCOVA were applied to assess between- and within-group differences, adjusting for baseline values. Significant within-group changes were observed in body weight and body mass index across all groups (P < .05). Between-group differences emerged in fat mass, fat percentage, and body mass index at multiple time points (P < .05); however, none remained significant after adjusting for baseline using Quade ANCOVA (all P > .05). Notably, several parameters showed medium to large effect sizes, despite nonsignificant P values. Under controlled conditions, moderate caffeine intake ( approximately 95 to 100 mg) or 200 mL fluid volume does not induce significant short-term alterations in BIA-derived body composition in healthy women. Visual trends suggest transient fluctuations within the first 60 minutes, though these were not clinically meaningful. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Sabuncular, Guleren AU - Sabuncular G AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Marmara University, Maltepe, Istanbul, Turkiye. Electronic address: guleren.sabuncular@marmara.edu.tr. FAU - Agopyan, Ani AU - Agopyan A AD - Training and Movement Science, Department of Coaching Education, Faculty of Sport Sciences, Marmara University, Istanbul, Turkiye. FAU - Acikgoz, Ayse AU - Acikgoz A AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Marmara University, Maltepe, Istanbul, Turkiye. FAU - Karatay, Habibe Nur AU - Karatay HN AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Marmara University, Maltepe, Istanbul, Turkiye. FAU - Ali Ozturk, Muhammet AU - Ali Ozturk M AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Marmara University, Maltepe, Istanbul, Turkiye. FAU - Yildiz, Ruveyda Gulce AU - Yildiz RG AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Marmara University, Maltepe, Istanbul, Turkiye. FAU - Aktac, Sule AU - Aktac S AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Marmara University, Maltepe, Istanbul, Turkiye. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260413 PL - United States TA - Nutr Res JT - Nutrition research (New York, N.Y.) JID - 8303331 RN - 0 (Coffee) RN - 3G6A5W338E (Caffeine) SB - IM MH - Humans MH - Female MH - *Coffee/chemistry MH - Adult MH - *Electric Impedance MH - Young Adult MH - *Caffeine/pharmacology/administration & dosage MH - *Body Composition/drug effects MH - Adolescent MH - Body Mass Index MH - Drinking MH - Body Weight MH - Reproducibility of Results OTO - NOTNLM OT - Bioelectrical impedance analysis OT - Body composition OT - Caffeinated coffee OT - Decaffeinated coffee OT - Water COIS- Author declarations The authors declare no competing interests. EDAT- 2026/05/09 00:34 MHDA- 2026/05/28 00:29 CRDT- 2026/05/08 18:10 PHST- 2025/08/14 00:00 [received] PHST- 2026/04/02 00:00 [revised] PHST- 2026/04/06 00:00 [accepted] PHST- 2026/05/28 00:29 [medline] PHST- 2026/05/09 00:34 [pubmed] PHST- 2026/05/08 18:10 [entrez] AID - S0271-5317(26)00041-2 [pii] AID - 10.1016/j.nutres.2026.04.002 [doi] PST - ppublish SO - Nutr Res. 2026 Jun;150:62-71. doi: 10.1016/j.nutres.2026.04.002. Epub 2026 Apr 13. PMID- 42102099 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 5 DP - 2026 TI - Research on the development and differentiation of the physical literacy scale for Chinese college students. PG - e0348776 LID - 10.1371/journal.pone.0348776 [doi] LID - e0348776 AB - OBJECTIVES: To understand the current status and characteristics of physical literacy among Chinese college students, develop a measurement scale suitable for this population, and provide an appropriate assessment tool for related research. METHODS: The Delphi method and a questionnaire survey were initially employed to screen and evaluate the reliability and validity of 53 preliminary items. Subsequently, the finalized measurement tool, which had been assessed for reliability, was administered to 3,077 Chinese college students via a questionnaire survey to identify population variation characteristics. RESULTS: Following a systematic screening process, the reliability coefficients for the four dimensions ranged from 0.731 to 0.821, and a reliable measurement tool for assessing physical literacy among Chinese college students was established. The final scale comprises four dimensions-physical activity capacity, physical activity behavior, physical activity cognition, and emotional experience-with a total of 32 items. The survey revealed significant differences in physical literacy among Chinese college students across the following dimensions: gender (t = 24.914, P < 0.001), household registration (t = 11.464, P < 0.001), grade (F = 30.811, P < 0.001), university category (F = 17.305, P < 0.001), and university district (F = 4.957, P < 0.01). Furthermore, significant differences were observed to varying degrees across all four dimensions-physical activity capacity, physical activity behavior, physical activity cognition, and emotional experience. CONCLUSION: The developed Physical Literacy Scale for Chinese College Students is suitable for research targeting this population. The survey revealed significant differences in physical literacy levels among Chinese college students based on gender, grade, household registration, university category, and university district. CI - Copyright: (c) 2026 Ni, Yu. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Ni, Rongjing AU - Ni R AUID- ORCID: 0000-0001-6133-9743 AD - Physical Education Institute, Liaoning Normal University, Dalian, China. FAU - Yu, Ying AU - Yu Y AUID- ORCID: 0000-0002-0810-3886 AD - Physical Education Institute, Liaoning Normal University, Dalian, China. LA - eng PT - Journal Article DEP - 20260508 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Students/psychology MH - Female MH - Male MH - Universities MH - Surveys and Questionnaires MH - China MH - Young Adult MH - Reproducibility of Results MH - Adolescent MH - *Exercise MH - Adult MH - *Health Literacy PMC - PMC13155614 COIS- The authors have declared that no competing interests exist. EDAT- 2026/05/08 18:33 MHDA- 2026/05/08 18:34 PMCR- 2026/05/08 CRDT- 2026/05/08 13:43 PHST- 2025/12/21 00:00 [received] PHST- 2026/04/19 00:00 [accepted] PHST- 2026/05/08 18:34 [medline] PHST- 2026/05/08 18:33 [pubmed] PHST- 2026/05/08 13:43 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - PONE-D-25-65782 [pii] AID - 10.1371/journal.pone.0348776 [doi] PST - epublish SO - PLoS One. 2026 May 8;21(5):e0348776. doi: 10.1371/journal.pone.0348776. eCollection 2026. PMID- 42101376 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1542-4758 (Electronic) IS - 1492-7535 (Print) IS - 1492-7535 (Linking) VI - 30 IP - 3 DP - 2026 Jul TI - Bioelectrical Impedance in Pediatric Dialysis: Clinical Applications, Limitations, and Opportunities. PG - 486-498 LID - 10.1111/hdi.70073 [doi] AB - BACKGROUND: Optimizing fluid and nutritional management is a cornerstone of care for children with end-stage kidney disease on dialysis. Inaccurate assessment of hydration status contributes to hypertension, fluid overload, and increased cardiovascular risk, while masking important changes in muscle and fat compartments that affect growth and long-term outcomes. Bioelectrical impedance analysis (BIA) offers clinicians a noninvasive, rapid, and practical tool to support decision-making in this setting. AIMS: This review aims to provide clinicians with a practical framework for the use of BIA in pediatric dialysis, including its clinical applications, limitations, and opportunities for integration into routine care. MATERIALS AND METHODS: A narrative review of the literature was conducted, and findings were synthesized focusing on the principles of BIA, device technologies, and clinical studies evaluating its use in pediatric dialysis populations. Emphasis was placed on studies addressing fluid assessment, body composition, and clinical implementation. Adult literature was included where pediatric literature was lacking. RESULTS: Available evidence suggests BIA can provide useful estimates of total body water, fat mass, and lean tissue that may support ultrafiltration strategies, nutritional assessment, and longitudinal monitoring. Key limitations include variability related to growth, delayed maturation, obesity, malnutrition, and reliance on adult-derived prediction equations. Current evidence supports BIA as an adjunctive tool integrated with clinical assessment rather than a standalone measure. DISCUSSION: BIA may enhance individualized fluid and nutritional management when interpreted within the clinical context and standardized measurement protocols. Broader implementation requires awareness of pediatric-specific limitations, interdisciplinary interpretation, and cautious use of device-derived estimates. CONCLUSION: BIA is a practical adjunct for pediatric dialysis care with potential to improve fluid management and nutritional monitoring. Pediatric-specific validation studies, standardized protocols, and integration with clinical outcomes is needed to optimize its utility. CI - (c) 2026 The Author(s). Hemodialysis International published by Wiley Periodicals LLC on behalf of International Society for Hemodialysis. FAU - Juarez-Calderon, Marisa AU - Juarez-Calderon M AD - Department of Renal & Pheresis Services, Texas Children's Hospital, Houston, Texas, USA. FAU - Geer, Jessica AU - Geer J AD - Department of Renal & Pheresis Services, Texas Children's Hospital, Houston, Texas, USA. AD - Department of Pediatrics, Section of Pediatric Nephrology, Baylor College of Medicine, Houston, Texas, USA. FAU - Wong Vega, Molly AU - Wong Vega M AUID- ORCID: 0000-0003-4732-4996 AD - Department of Renal & Pheresis Services, Texas Children's Hospital, Houston, Texas, USA. AD - Department of Pediatrics, Section of Pediatric Nephrology, Baylor College of Medicine, Houston, Texas, USA. LA - eng PT - Journal Article PT - Review DEP - 20260508 PL - Canada TA - Hemodial Int JT - Hemodialysis international. International Symposium on Home Hemodialysis JID - 101093910 SB - IM MH - Humans MH - *Electric Impedance MH - *Renal Dialysis/methods MH - Child MH - Body Composition MH - *Kidney Failure, Chronic/therapy PMC - PMC13350307 OTO - NOTNLM OT - dry weight assessment OT - fluid overload OT - fluid status OT - hydration status OT - nutritional risk COIS- The authors declare no conflicts of interest. EDAT- 2026/05/08 12:38 MHDA- 2026/07/10 12:46 PMCR- 2026/07/10 CRDT- 2026/05/08 10:23 PHST- 2026/04/02 00:00 [revised] PHST- 2025/09/25 00:00 [received] PHST- 2026/04/26 00:00 [accepted] PHST- 2026/07/10 12:46 [medline] PHST- 2026/05/08 12:38 [pubmed] PHST- 2026/05/08 10:23 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - HDI70073 [pii] AID - 10.1111/hdi.70073 [doi] PST - ppublish SO - Hemodial Int. 2026 Jul;30(3):486-498. doi: 10.1111/hdi.70073. Epub 2026 May 8. PMID- 42101192 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1473-0766 (Electronic) IS - 0951-3590 (Linking) VI - 42 IP - 1 DP - 2026 Dec 31 TI - Inflammatory markers mediate the association of the Zhejiang University index with gestational diabetes mellitus: data from NHANES 2007-2020. PG - 2668870 LID - 10.1080/09513590.2026.2668870 [doi] AB - BACKGROUND: Gestational diabetes mellitus (GDM) threatens maternal and infant health, yet early prediction is challenging. The Zhejiang University (ZJU) index, reflecting insulin resistance and hepatic lipid metabolism, predicts metabolic diseases, but its role in GDM across multiethnic populations is unclear. METHODS: This study analyzed NHANES 2007-2020 data from US women aged 20-45. Weighted logistic regression, restricted cubic spline (RCS), subgroup, and ROC analyses assessed ZJU index and GDM. Mediation analysis evaluated inflammatory ratios. Sensitivity analysis excluded women with chronic diseases or medication use. RESULTS: Among 2240 women, 10% had GDM. Higher ZJU index was linearly associated with increased GDM risk; highest quartile had over twice the odds (OR = 2.25, 95% CI: 1.10-3.41). ZJU index outperformed BMI, FPG, ALT, AST (AUC = 0.718). PHR and LHR partially mediated the association. Sensitivity analysis confirmed robustness. CONCLUSION: ZJU index is a strong, independent predictor of GDM, outperforming traditional markers. HDL‑related inflammatory markers partially mediate this association, suggesting immunometabolic pathways. Further studies are needed for validation in broader populations. FAU - Ye, Mengmeng AU - Ye M AD - Department of Obstetrics and Gynecology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, People's Republic of China. FAU - Wu, Haochan AU - Wu H AD - Department of Obstetrics and Gynecology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, People's Republic of China. FAU - Shan, Fangfang AU - Shan F AD - Department of Obstetrics and Gynecology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, People's Republic of China. FAU - Zhou, Hui AU - Zhou H AD - Department of Obstetrics and Gynecology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, People's Republic of China. AD - Human Genetic and Reproduction Center, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, People's Republic of China. FAU - Yu, Jinjin AU - Yu J AD - Department of Obstetrics and Gynecology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, People's Republic of China. FAU - Wu, Yibo AU - Wu Y AD - Department of Obstetrics and Gynecology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, People's Republic of China. AD - Human Genetic and Reproduction Center, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, People's Republic of China. FAU - Hao, Tingting AU - Hao T AD - Department of Laboratory Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, People's Republic of China. LA - eng PT - Journal Article DEP - 20260508 PL - England TA - Gynecol Endocrinol JT - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JID - 8807913 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - *Diabetes, Gestational/blood/epidemiology/diagnosis MH - Pregnancy MH - Adult MH - Biomarkers/blood MH - Nutrition Surveys MH - *Insulin Resistance/physiology MH - *Inflammation/blood MH - Young Adult MH - United States/epidemiology OTO - NOTNLM OT - Zhejiang University (ZJU) index OT - gestational diabetes mellitus (GDM) OT - inflammation OT - lymphocyte-to-HDL ratio (LHR) OT - platelet-to-HDL ratio (PHR) EDAT- 2026/05/08 12:37 MHDA- 2026/05/08 12:38 CRDT- 2026/05/08 09:23 PHST- 2026/05/08 12:38 [medline] PHST- 2026/05/08 12:37 [pubmed] PHST- 2026/05/08 09:23 [entrez] AID - 10.1080/09513590.2026.2668870 [doi] PST - ppublish SO - Gynecol Endocrinol. 2026 Dec 31;42(1):2668870. doi: 10.1080/09513590.2026.2668870. Epub 2026 May 8. PMID- 42100063 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260508 LR - 20260813 IS - 2529-198X (Electronic) IS - 2529-198X (Linking) VI - 37 IP - 1 DP - 2026 Mar TI - Translation and Validation of the Greek Version of the Revised Fibromyalgia Impact Questionnaire (FIQR). PG - 156-163 LID - 10.31138/mjr.190525.ria [doi] AB - OBJECTIVE: Increasing awareness of chronic pain conditions, such as fibromyalgia, requires validated tools to monitor the impact of the disease and response to treatment. This study aimed to translate and validate the Revised Fibromyalgia Impact Questionnaire (FIQR) in Greek patients with fibromyalgia. METHODS: The FIQR was translated into Greek (FIQR-GR) using the forward-backward-forward method. A total of 311 adults participated in this validation study by completing questionnaires and reporting their demographic characteristics (age, gender, weight, height, education, profession, and number of children). Internal consistency was evaluated using Cronbach's alpha, and confirmatory factor analysis (CFA) was conducted to assess the structural validity of the tool. Regression models were used to test the association between FIQR and demographic characteristics. RESULTS: The FIQR-GR demonstrated excellent internal consistency (Cronbach's alpha=0.94, function domain 0.92, Overall Impact domain 0.85, symptoms domain 0.85). CFA revealed goodness of fit (CFI=0.900, RMSEA=0.080, SRMR=0.056) and confirmed the original three-factor model. Most items had high standardised factor loadings (0.51 to 0.86), providing strong evidence for validity, although two items had lower values than expected (0.40 for energy levels, 0.48 for depression). There was a significant positive association between FIQR and body mass index (BMI) (p<0.001), suggesting that patients with a higher BMI experienced more severe fibromyalgia symptoms. CONCLUSION: The FIQR-GR is a valid and reliable tool for Greek patients with fibromyalgia and a valuable tool in clinical and research settings. CI - (c) 2026 The Author(s). FAU - Gkouvi, Arriana AU - Gkouvi A AD - Immunonutrition Unit, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, Larissa, Greece. FAU - Pardali, Eleni C AU - Pardali EC AD - Immunonutrition Unit, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, Larissa, Greece. FAU - Kontouli, Katerina Maria AU - Kontouli KM AD - Laboratory of Hygiene and Epidemiology, Faculty of Medicine, University of Thessaly, Larissa, Greece. AD - Department of Primary Education, School of Education, University of Ioannina, Ioannina, Greece. FAU - Patrikiou, Eleni AU - Patrikiou E AD - Immunonutrition Unit, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, Larissa, Greece. FAU - Bogdanos, Dimitrios P AU - Bogdanos DP AD - Immunonutrition Unit, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, Larissa, Greece. FAU - Goulis, Dimitrios G AU - Goulis DG AD - Unit of Reproductive Endocrinology, 1 Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Grammatikopoulou, Maria G AU - Grammatikopoulou MG AD - Immunonutrition Unit, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, Larissa, Greece. LA - eng PT - Journal Article DEP - 20260301 PL - Greece TA - Mediterr J Rheumatol JT - Mediterranean journal of rheumatology JID - 101730166 PMC - PMC13145287 OTO - NOTNLM OT - FIQR OT - Revised Fibromyalgia Impact Questionnaire OT - fibromyalgia OT - pain OT - validation COIS- None. EDAT- 2026/05/08 06:33 MHDA- 2026/05/08 06:34 PMCR- 2026/03/01 CRDT- 2026/05/08 05:01 PHST- 2025/05/19 00:00 [received] PHST- 2025/07/14 00:00 [revised] PHST- 2025/07/28 00:00 [accepted] PHST- 2026/05/08 06:34 [medline] PHST- 2026/05/08 06:33 [pubmed] PHST- 2026/05/08 05:01 [entrez] PHST- 2026/03/01 00:00 [pmc-release] AID - MJR-37-1-156 [pii] AID - 10.31138/mjr.190525.ria [doi] PST - epublish SO - Mediterr J Rheumatol. 2026 Mar 1;37(1):156-163. doi: 10.31138/mjr.190525.ria. eCollection 2026 Mar. PMID- 42099720 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260508 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Acute psychological responses to official match outcomes in male youth volleyball: an observational repeated-measures study within a single national-level team. PG - 1826372 LID - 10.3389/fpsyg.2026.1826372 [doi] LID - 1826372 AB - BACKGROUND: Official match outcomes may be associated with acute psychological responses in youth athletes, particularly in team sports characterized by high emotional and interpersonal demands. OBJECTIVE: To examine acute psychological responses in male youth volleyball athletes during official matches in a national-level competition, focusing on associations with match outcome (win vs. loss), playing status (starter vs. substitute), and assessment moment (pre- vs. post-match). METHODS: Fourteen male athletes (mean age 16.5 +/- 0.82 years) from a single Brazilian national-level team were followed across 20 official matches (14 wins and 6 losses). Psychological responses were assessed before and/or after matches using validated instruments: State Anxiety (STAI-IDATE), Brunel Mood Scale (BRUMS), Feeling Scale, Physical Activity Enjoyment Scale (PACES), and Total Quality Recovery (TQR). Generalized estimating equations (GEE) were used with an independent working correlation structure and robust (sandwich) standard errors. Fixed effects included match outcome, playing status, assessment moment, and their interactions. Candidate marginal models were compared via Independence Model Criterion under a parsimonious strategy suitable for small samples. RESULTS: Losses were associated with increased post-match state anxiety, tension, depression, anger, and confusion, whereas wins were generally associated with stability or more favorable responses in these dimensions. Affective valence also showed an outcomexmoment interaction, declining after losses but remaining relatively stable after wins. Vigor demonstrated a three-way interaction between playing status, outcome, and moment, with substitutes showing a more pronounced decline after losses. Fatigue showed main effects of playing status, match outcome, and moment. Enjoyment was higher in wins than losses and higher in starters than substitutes. Perceived recovery showed a playing statusxoutcome interaction, with starters reporting higher pre-match recovery before matches that resulted in wins. CONCLUSION: In this single-team observational sample, acute psychological responses appeared to vary according to match outcome, playing status, and assessment moment. These findings should be interpreted as exploratory associations and may support the practical value of psychological monitoring in youth competitive volleyball. CI - Copyright (c) 2026 Do Nascimento, Sa Filho, Aprigliano, Clemente, Vieira, Campos, Rocha, Arantes, Pedrosa, Noll, Kawczynski, Laporta and Costa. FAU - Do Nascimento, Marcos Henrique AU - Do Nascimento MH AD - Programa de Pos-Graduacao em Ciencias da Saude, Faculdade de Medicina, Universidade Federal de Goias, Goiania, Brazil. FAU - Sa Filho, Alberto Souza AU - Sa Filho AS AD - Human Movement and Rehabilitation, Universidade Evangelica de Goias, Anapolis, Brazil. AD - Graduate Program at the Federal University of Rio de Janeiro, UFRJ, Rio de Janeiro, Brazil. FAU - Aprigliano, Vicente AU - Aprigliano V AD - Escuela de Ingenieria de Construccion y Transporte, Pontificia Universidad Catolica de Valparaiso, Valparaiso, Chile. FAU - Clemente, Filipe Manuel AU - Clemente FM AD - Department of Biomechanics, Gdansk University of Physical Education and Sport, Gdansk, Poland. AD - Applied Research Institute (i2A), Polytechnic University of Coimbra, Coimbra, Portugal. AD - Sport Physical Activity and Health Research & Innovation Center, Coimbra, Portugal. FAU - Vieira, Carlos Alexandre AU - Vieira CA AD - Programa de Pos-Graduacao em Ciencias da Saude, Faculdade de Medicina, Universidade Federal de Goias, Goiania, Brazil. FAU - Campos, Mario Hebling AU - Campos MH AD - Programa de Pos-Graduacao em Ciencias da Saude, Faculdade de Medicina, Universidade Federal de Goias, Goiania, Brazil. FAU - Rocha, Augusto Cezar Rodrigues AU - Rocha ACR AD - Programa de Pos-Graduacao em Ciencias da Saude, Faculdade de Medicina, Universidade Federal de Goias, Goiania, Brazil. FAU - Arantes, Debora Darck Lopes Costa AU - Arantes DDLC AD - Programa de Pos-Graduacao em Ciencias da Saude, Faculdade de Medicina, Universidade Federal de Goias, Goiania, Brazil. FAU - Pedrosa, Gustavo Ferreira AU - Pedrosa GF AD - Centro de Educacao Fisica e Desportos, Universidade Federal de Santa Maria, Santa Maria, Brazil. FAU - Noll, Matias AU - Noll M AD - Instituto Federal de Educacao, Ciencia e Tecnologia Goiano, Ceres, Brazil. FAU - Kawczynski, Adam AU - Kawczynski A AD - Faculty of Medicine, Wroclaw University of Science and Technology, Wroclaw, Poland. FAU - Laporta, Lorenzo AU - Laporta L AD - Centro de Educacao Fisica e Desportos, Universidade Federal de Santa Maria, Santa Maria, Brazil. FAU - Costa, Gustavo De Conti Teixeira AU - Costa GCT AD - Programa de Pos-Graduacao em Ciencias da Saude, Faculdade de Medicina, Universidade Federal de Goias, Goiania, Brazil. LA - eng PT - Journal Article DEP - 20260422 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13143687 OTO - NOTNLM OT - Brunel Mood Scale OT - Physical Activity Enjoyment Scale OT - Total Quality Recovery OT - affective valence OT - ecological validity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/08 06:32 MHDA- 2026/05/08 06:33 PMCR- 2026/04/22 CRDT- 2026/05/08 04:58 PHST- 2026/03/09 00:00 [received] PHST- 2026/04/03 00:00 [revised] PHST- 2026/04/10 00:00 [accepted] PHST- 2026/05/08 06:33 [medline] PHST- 2026/05/08 06:32 [pubmed] PHST- 2026/05/08 04:58 [entrez] PHST- 2026/04/22 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1826372 [doi] PST - epublish SO - Front Psychol. 2026 Apr 22;17:1826372. doi: 10.3389/fpsyg.2026.1826372. eCollection 2026. PMID- 42099518 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260508 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Status Quo analysis of an exercise therapy care model in pediatric oncology during acute therapy: perspectives from patients, parents, siblings, and staff. PG - 1791439 LID - 10.3389/fped.2026.1791439 [doi] LID - 1791439 AB - BACKGROUND: In oncological pediatrics, exercise therapy is still not part of regular medical care in Germany and exercise therapy projects are currently financed by charity organizations. Nevertheless, the scientific evidence for the benefit of exercise therapy in pediatric oncology has led to the implementation of exercise therapy programs at most of the German hospitals. At the Pediatric Oncology Department of the University Hospital of Cologne the exercise therapy program was established in 2021. Between 2023 and 2025 a comprehensive survey was carried out to assess the perception of various groups such as patients, family and staff with offered program. METHODS: A monocentric survey was conducted to assess the perception of patients, parents, siblings, and staff members regarding the exercise project using non-validated questionnaires. The questionnaires addressed the exercise project during intensive medical therapy in both the outpatient and inpatient phases. The questionnaires contained both open and closed questions and were evaluated using the following categories: "Communication/Education", "Participation", "Satisfaction", "Need for Support", "Online Exercise Sessions", and "Barriers and Motives". RESULTS: The survey was completed by 33 patients, 63 parents, 14 siblings and 48 staff members. The evaluation of the survey showed that more than 50% of the patients and parents surveyed were satisfied with the existing program. Parents and staff have particularly noted the lack of exercise therapy programs for patients during their outpatient phases. DISCUSSION: Despite the generally positive evaluation, patients, parents, siblings and staff still see potential for further development of the exercise therapy program, especially for the outpatient phases. CONCLUSION: Although the physical activity program is highly regarded, its potential is limited by gaps in outpatient care and inadequate sibling integration. To improve exercise therapy further, a holistic, family-centered approach must expand beyond the inpatient setting. Overcoming skepticism toward telehealth is crucial to ensuring accessible, sustainable exercise therapy outside the hospital.Clinical Trial Registration: https://drks.de/search/de/trial/DRKS00034629/details, identifier (DRKS00034629). CI - (c) 2026 Bohlke, Simon, Hero, Reinke, Friedrich, Zoth and Baumann. FAU - Bohlke, Lena AU - Bohlke L AD - Department of Pediatric Hematology and Oncology, University Hospital of Cologne, Cologne, Germany. FAU - Simon, Thorsten AU - Simon T AD - Department of Pediatric Hematology and Oncology, University Hospital of Cologne, Cologne, Germany. FAU - Hero, Barbara AU - Hero B AD - Department of Pediatric Hematology and Oncology, University Hospital of Cologne, Cologne, Germany. FAU - Reinke, Dana AU - Reinke D AD - Department of Pediatric Hematology and Oncology, University Hospital of Cologne, Cologne, Germany. FAU - Friedrich, Amrei AU - Friedrich A AD - Department of Pediatric Hematology and Oncology, University Hospital of Cologne, Cologne, Germany. FAU - Zoth, Nora AU - Zoth N AD - Department I of Internal Medicine, Center for Integrated Oncology Cologne Bonn, University Hospital of Cologne, Cologne, Germany. FAU - Baumann, Freerk T AU - Baumann FT AD - Department I of Internal Medicine, Center for Integrated Oncology Cologne Bonn, University Hospital of Cologne, Cologne, Germany. LA - eng PT - Journal Article DEP - 20260422 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13144044 OTO - NOTNLM OT - acute medical treatment OT - childhood cancer OT - exercise therapy OT - pediatric oncology OT - physical activity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/08 06:32 MHDA- 2026/05/08 06:33 PMCR- 2026/04/22 CRDT- 2026/05/08 04:55 PHST- 2026/01/19 00:00 [received] PHST- 2026/04/03 00:00 [revised] PHST- 2026/04/07 00:00 [accepted] PHST- 2026/05/08 06:33 [medline] PHST- 2026/05/08 06:32 [pubmed] PHST- 2026/05/08 04:55 [entrez] PHST- 2026/04/22 00:00 [pmc-release] AID - 10.3389/fped.2026.1791439 [doi] PST - epublish SO - Front Pediatr. 2026 Apr 22;14:1791439. doi: 10.3389/fped.2026.1791439. eCollection 2026. PMID- 42099515 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260508 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Co-occurrence of suspected scoliosis and sagittal spinal deviations among early adolescents: a school-based cross-sectional study of prevalence and associated factors. PG - 1769144 LID - 10.3389/fped.2026.1769144 [doi] LID - 1769144 AB - AIMS: This study aimed to investigate the prevalence and patterns of spinal postural abnormalities, particularly the co-occurrence of suspected scoliosis and sagittal spinal deviation, and to identify associated biological, behavioral, and psychosocial factors among early adolescents aged 12 to14 years. METHODS: A school-based, cross-sectional study was conducted among 255 school children aged 12 to 14 years. The standardized postural assessments and validated questionnaires were used to obtain data on the spinal alignment, anthropometric measures, pain location, and behavioral and psychosocial characteristics. Frontal and sagittal deviations were assessed through standardized visual inspection procedures. Frontal deviations indicating suspected scoliosis were further examined using the Adam's forward bending test and the angle of trunk rotation (ATR) measured with a scoliometer. Behavioral variables included screen time and preferred posture during screen use, while psychosocial variables comprised knowledge, attitude, and practice (KAP) and self-postural awareness questionnaires. Associated factors were identified by performing comparative analyses and binary logistic regression. RESULTS: Combined suspected scoliosis and sagittal spinal deviations were found in 21.2 percent of participants, with flattened thoracic curvature being the most frequent sagittal abnormality. Logistic regression revealed greater body height (AOR = 1.06, 95% CI: 1.02-1.11), lower KAP scores (AOR = 0.80, 95% CI: 0.72-0.89), while screen time (AOR = 1.22, 95% CI: 1.01-1.49) showed a more limited association with combined spinal deviations. Participants with suspected scoliosis reported more frequent upper back pain and lower self-postural awareness than those without deviations. CONCLUSION: A noteworthy proportion of early adolescents exhibited combined spinal deformities associated with biological and psychosocial-behavioral factors. Greater body height and lower KAP scores showed clearer associations with these conditions, whereas screen time demonstrated a tendency toward an association. These findings highlight the importance of incorporating posture assessment and health education into school-based initiatives. Improving early identification and encouraging healthy lifestyle behaviors may contribute to better spinal health and help reduce the risk of long-term musculoskeletal problems during adolescence. CI - (c) 2026 Nilmart and Vongsirinavarat. FAU - Nilmart, Patcharin AU - Nilmart P AD - Faculty of Physical Therapy, Srinakharinwirot University, Ongkharak, Nakhon Nayok, Thailand. FAU - Vongsirinavarat, Mantana AU - Vongsirinavarat M AD - Faculty of Physical Therapy, Mahidol University, Putthamonthon, Nakhon Pathom, Thailand. LA - eng PT - Journal Article DEP - 20260422 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13144105 OTO - NOTNLM OT - adolescents OT - health behavior OT - musculoskeletal health OT - school health OT - scoliosis OT - spinal curvature COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/08 06:32 MHDA- 2026/05/08 06:33 PMCR- 2026/04/22 CRDT- 2026/05/08 04:55 PHST- 2025/12/16 00:00 [received] PHST- 2026/01/28 00:00 [revised] PHST- 2026/04/08 00:00 [accepted] PHST- 2026/05/08 06:33 [medline] PHST- 2026/05/08 06:32 [pubmed] PHST- 2026/05/08 04:55 [entrez] PHST- 2026/04/22 00:00 [pmc-release] AID - 10.3389/fped.2026.1769144 [doi] PST - epublish SO - Front Pediatr. 2026 Apr 22;14:1769144. doi: 10.3389/fped.2026.1769144. eCollection 2026. PMID- 42098660 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 May 7 TI - Does stunting modify the impact of salivary factors and early childhood caries on oral health-related quality of life? LID - 10.1186/s12889-026-27304-5 [doi] LID - 1987 AB - BACKGROUND: Stunting, a form of chronic malnutrition, is associated with impaired growth and potential changes in salivary function that may increase susceptibility to early childhood caries (ECC). These oral conditions may further influence a child's oral health-related quality of life (OHRQoL). However, the extent to which stunting modifies the impact of salivary factors and ECC on OHRQoL remains unclear. METHODS: This analytical cross-sectional study included 210 preschool children aged 24-59 months in Bandung, Indonesia, equally divided into stunted and non-stunted groups based on height-for-age z-scores (HAZ <-2 SD for stunted). Dental caries was assessed using the deft index, while salivary pH and buffering capacity were measured using the GC Saliva Check Buffer Test. OHRQoL was evaluated using a modified Early Childhood Oral Health Impact Scale (ECOHIS) with a dichotomous response format (never = 0, ever = 1) validated through pilot testing (Cronbach's alpha = 0.870). Statistical analyses included Mann-Whitney U, Chi-square, and t-tests, followed by logistic regression with interaction terms to examine effect modification by stunting. RESULTS: Non-stunted children had higher mean deft scores (6.50 +/- 4.43) compared to stunted children (5.12 +/- 4.38, p = 0.020). Acidic Saliva was more frequent among stunted children (11.4%) than non-stunted children (3.8%, p = 0.037). However, no significant differences were observed in ECOHIS total scores or in the impact of OHRQoL between groups (p > 0.05). Logistic regression revealed no significant interactions between stunting, ECC, salivary pH, or buffering capacity (all p > 0.05). CONCLUSION: Stunting did not affect the association between salivary factors, early childhood caries, and oral health-related quality of life in preschool children. Although children with stunted had slightly higher salivary acidity, these differences did not result in measurable differences in quality of life. Prevention should combine oral health education and nutritional interventions to comprehensively address the risk of stunting and dental caries. CI - (c) 2026. The Author(s). FAU - Setiawan, Arlette Suzy AU - Setiawan AS AUID- ORCID: 0000-0001-5005-8081 AD - Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia. arlette.puspa@unpad.ac.id. FAU - Caesarini, Meitty AU - Caesarini M AD - Pediatric Dentistry Residency Program, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia. FAU - Musnamirwan, Iwan Ahmad AU - Musnamirwan IA AUID- ORCID: 0000-0002-2077-0630 AD - Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia. FAU - Primarti, Risti Saptarini AU - Primarti RS AUID- ORCID: 0009-0007-4456-3162 AD - Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia. FAU - Indriyanti, Ratna AU - Indriyanti R AUID- ORCID: 0000-0003-1864-5301 AD - Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia. LA - eng PT - Journal Article DEP - 20260507 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - *Dental Caries/epidemiology MH - Cross-Sectional Studies MH - Male MH - Female MH - *Quality of Life MH - Child, Preschool MH - *Saliva/chemistry/physiology MH - Indonesia/epidemiology MH - *Oral Health/statistics & numerical data MH - *Growth Disorders/complications/epidemiology MH - Hydrogen-Ion Concentration PMC - PMC13321754 OTO - NOTNLM OT - Child OT - Dental Caries OT - Growth Disorders OT - Hydrogen-Ion Concentration OT - Preschool OT - Quality of Life OT - Saliva COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the ethical standards of the Health Research Ethics Committee of Universitas Padjadjaran and with the 1964 Helsinki Declaration and its later amendments. Ethical approval was obtained under reference number 125/UN6.KEP/EC/2025. Written informed consent was obtained from all participants and/or their legal guardians prior to participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. Clinical trial number: not applicable. EDAT- 2026/05/08 00:32 MHDA- 2026/07/01 12:47 PMCR- 2026/05/07 CRDT- 2026/05/07 23:45 PHST- 2025/12/24 00:00 [received] PHST- 2026/04/02 00:00 [accepted] PHST- 2026/07/01 12:47 [medline] PHST- 2026/05/08 00:32 [pubmed] PHST- 2026/05/07 23:45 [entrez] PHST- 2026/05/07 00:00 [pmc-release] AID - 10.1186/s12889-026-27304-5 [pii] AID - 27304 [pii] AID - 10.1186/s12889-026-27304-5 [doi] PST - epublish SO - BMC Public Health. 2026 May 7;26(1):1987. doi: 10.1186/s12889-026-27304-5. PMID- 42098264 OWN - NLM STAT- MEDLINE DCOM- 20260912 LR - 20261029 IS - 1476-5578 (Electronic) IS - 1359-4184 (Print) IS - 1359-4184 (Linking) VI - 31 IP - 10 DP - 2026 Oct TI - Physiological Age and Homeostatic Dysregulation Following Child Maltreatment in Youth. PG - 5586-5594 LID - 10.1038/s41380-026-03642-z [doi] AB - Child maltreatment has been associated with biological hallmarks of aging, including telomere shortening and epigenetic instability; however, its influence on physiological age and homeostatic dysregulation in early life remains unclear. The current study examined pediatric versions of physiological age and homeostatic dysregulation in children aged 8-13 with and without exposure to maltreatment. Maltreatment exposure was determined based on investigational records within 12 months prior to enrollment. Physiological measures were trained and validated utilizing external datasets - the National Health and Nutrition Examination Survey III and IV, respectively. Physiological age was computed using the Klemera-Doubal Method to indicate physiological developmental status. Homeostatic dysregulation level was computed as the Mahalanobis distance from an external reference group. 216 females and 245 males with a mean age of 11.4 years (SD 1.5) were included (76.6% White, 13.2% Black, and 13.0% Hispanic, 76.6% with maltreatment). Exposure to maltreatment was not associated with changes in physiological age but was associated with greater homeostatic dysregulation. Further analyses by maltreatment type and sex revealed that physical abuse was associated with greater homeostatic dysregulation, while sexual abuse was associated with delayed physiological development, specifically in males. Exposure to multiple types of maltreatment was associated with greater homeostatic dysregulation among males, but not among females. This study revealed that recent exposure to certain types of maltreatment may impair physiological development or regulation in children, with sex-specific patterns suggesting greater effects in males. Findings further indicate that physiological development composites in youth are sensitive to the impact of child maltreatment and can be incorporated in future work to evaluate the long-term sequelae of adverse exposures in pediatric populations. As the impact of maltreatment was only nominally significant after correction for multiple testing, validation work in other samples is needed. CI - (c) 2026. The Author(s). FAU - Ye, Qiaofeng AU - Ye Q AD - Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, 16802, USA. FAU - Apsley, Abner T AU - Apsley AT AD - National Science Foundation Science and Technology Center for Quantitative Cell Biology, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. FAU - Etzel, Laura AU - Etzel L AD - Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, 16802, USA. FAU - Hastings, Waylon J AU - Hastings WJ AUID- ORCID: 0000-0003-0875-2568 AD - Department of Nutrition, Texas A&M University, College Station, TX, 77843, USA. AD - Institute for Advancing Health Through Agriculture, Texas A&M AgriLife, College Station, TX, 77843, USA. FAU - Chiaro, Christopher R AU - Chiaro CR AD - Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, 16802, USA. FAU - Schreier, Hannah M C AU - Schreier HMC AD - Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, 16802, USA. FAU - Claus, Eric D AU - Claus ED AUID- ORCID: 0000-0002-1800-0813 AD - Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, 16802, USA. FAU - Cohen, Alan A AU - Cohen AA AUID- ORCID: 0000-0003-4113-3988 AD - Department of Environmental Health Sciences and Robert N. Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, 10032, USA. FAU - Fisher, Zachary AU - Fisher Z AD - Department of Psychology and Neuroscience, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. FAU - Heim, Christine M AU - Heim CM AUID- ORCID: 0000-0002-6580-6326 AD - Charite - Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Institute of Medical Psychology, Berlin, 10117, Germany. AD - Charite - Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, NeuroCure Cluster of Excellence, Berlin, 10117, Germany. AD - German Center for Mental Health, Berlin Potsdam partner site, Berlin, 10117, Germany. FAU - Noll, Jennie G AU - Noll JG AD - Department of Psychology, University of Rochester, Rochester, NY, 14627, USA. AD - Mt. Hope Family Center, University of Rochester, Rochester, NY, 14627, USA. FAU - Shenk, Chad E AU - Shenk CE AD - Department of Psychology, University of Rochester, Rochester, NY, 14627, USA. AD - Mt. Hope Family Center, University of Rochester, Rochester, NY, 14627, USA. FAU - Shalev, Idan AU - Shalev I AUID- ORCID: 0000-0003-0773-4835 AD - Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, 16802, USA. ius14@psu.edu. LA - eng GR - P50 HD089922/HD/NICHD NIH HHS/United States GR - P50HD089922/U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)/ GR - R44 TR000045/TR/NCATS NIH HHS/United States GR - UL1 TR00045/U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS)/ GR - UL1 TR002014/TR/NCATS NIH HHS/United States GR - UL1 TR002014/U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS)/ PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260508 PL - England TA - Mol Psychiatry JT - Molecular psychiatry JID - 9607835 SB - IM MH - Humans MH - Female MH - Male MH - Child MH - *Homeostasis/physiology MH - *Child Abuse/psychology MH - Adolescent MH - *Aging/physiology MH - Nutrition Surveys PMC - PMC13160224 MID - NIHMS2162078 COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/05/08 00:32 MHDA- 2026/09/12 05:36 PMCR- 2026/05/08 CRDT- 2026/05/07 23:25 PHST- 2025/08/04 00:00 [received] PHST- 2026/04/30 00:00 [accepted] PHST- 2026/03/31 00:00 [revised] PHST- 2026/09/12 05:36 [medline] PHST- 2026/05/08 00:32 [pubmed] PHST- 2026/05/07 23:25 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - 10.1038/s41380-026-03642-z [pii] AID - 3642 [pii] AID - 10.1038/s41380-026-03642-z [doi] PST - ppublish SO - Mol Psychiatry. 2026 Oct;31(10):5586-5594. doi: 10.1038/s41380-026-03642-z. Epub 2026 May 8. PMID- 42097387 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1096-0953 (Electronic) IS - 0013-9351 (Linking) VI - 302 DP - 2026 Aug 1 TI - Associations of air pollution, road traffic noise, and greenness with adiposity markers in Swedish young adults. PG - 124646 LID - S0013-9351(26)00977-1 [pii] LID - 10.1016/j.envres.2026.124646 [doi] AB - BACKGROUND: Environmental exposures have been associated with adiposity, but the evidence remains inconsistent. We examined associations of several environmental exposures with adiposity in young adulthood, and body mass index (BMI) trajectories from birth to 24 years. METHODS: In the Swedish birth cohort BAMSE, individual-level exposure to air pollutants, road traffic noise, and greenness was estimated using validated models. Time-weighted averages were calculated for early-life (first year) and recent exposure (five years prior to clinical assessment). At age 24, waist circumference and body composition (i.e., body/trunk fat percentage, fat mass index (FMI)) using bioimpedance were measured (n = 1612). BMI trajectories based on anthropometrics repeatedly measured up to 24 years were identified via latent class mixture modeling. Sex-specific associations were estimated via linear and multinomial logistic regression. RESULTS: One interquartile range increase in early-life fine particulate matter /=20 is oft used to identify a probable eating disorder, previous work has shown that some items may reflect T1D management struggles, rather than DEB, with other work indicating that different response profiles (e.g., overeating vs. diabulimia) correspond to varying DEB risks. To identify DEPS-R items of greatest utility in detecting DEB in T1D, we used a form of item response theory to evaluate item variation in difficulty and discrimination, as well as scale precision across the latent DEB continuum. Participants were 329 adults with T1D who completed the DEPS-R when joining a participant registry or enrolling in a study on eating and weight concerns in T1D. We found a number of DEPS-R items (e.g., "I skip meals or snacks") that demonstrated low difficulty and low-to-moderate discrimination. These items were often endorsed by even the lowest severity participants yet provided relatively limited information for differentiating the DEB construct. Other items with high difficulty and moderate discrimination (e.g., "I make myself vomit") provided relatively modest information even at the highest pathology levels, as they were unlikely to be endorsed even by the most severe cases. Most high-discrimination items provided the most diagnostic information at the highest pathology levels (e.g., "I try to eat to the point of spilling ketones in my urine"). Results suggest revising the DEPS-R scale, as several items provided limited contribution to DEB detection. (PsycInfo Database Record (c) 2026 APA, all rights reserved). FAU - Dmitrieva, Natalia O AU - Dmitrieva NO AUID- ORCID: 0000-0001-7813-9131 AD - Department of Psychological Sciences, Northern Arizona University. FAU - Zhao, Corina Y AU - Zhao CY AD - Department of Counseling and Clinical Psychology, Teachers College, Columbia University. FAU - Moskovich, Ashley A AU - Moskovich AA AD - Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine. FAU - Roberts, Max Z AU - Roberts MZ AUID- ORCID: 0000-0002-5906-3992 AD - Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine. FAU - Merwin, Rhonda M AU - Merwin RM AUID- ORCID: 0000-0002-3729-0297 AD - Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine. LA - eng GR - R01 DK089329/DK/NIDDK NIH HHS/United States GR - DK/NIDDK NIH HHS/United States GR - JDRF/Breakthrough T1D/United States PT - Journal Article DEP - 20260507 PL - United States TA - Psychol Assess JT - Psychological assessment JID - 8915253 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/psychology/complications MH - Female MH - Adult MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Male MH - Middle Aged MH - Psychometrics MH - Young Adult MH - Surveys and Questionnaires MH - Adolescent PMC - PMC13152005 MID - NIHMS2153512 COIS- Conflicts of Interest: No authors nor their immediate family have a significant conflict of interest, nor any potential bias against another product or service. EDAT- 2026/05/07 12:37 MHDA- 2026/09/21 17:47 PMCR- 2026/05/08 CRDT- 2026/05/07 11:04 PHST- 2026/09/21 17:47 [medline] PHST- 2026/05/07 12:37 [pubmed] PHST- 2026/05/07 11:04 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - 2027-65075-001 [pii] AID - 10.1037/pas0001471 [doi] PST - ppublish SO - Psychol Assess. 2026 Oct;38(10):704-715. doi: 10.1037/pas0001471. Epub 2026 May 7. PMID- 42095152 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260507 LR - 20260813 IS - 2297-055X (Print) IS - 2297-055X (Electronic) IS - 2297-055X (Linking) VI - 13 DP - 2026 TI - Cardiopulmonary parameters in patients with Tetralogy of Fallot: the reference values for treadmill and cycle ergometer. PG - 1673478 LID - 10.3389/fcvm.2026.1673478 [doi] LID - 1673478 AB - BACKGROUND: The aim of this study was to establish sex- and age-specific reference values for ramp cycle-ergometer and treadmill cardiopulmonary exercise testing (CPET) in patients with Tetralogy of Fallot (ToF). Despite successful surgical repair, residual pulmonary regurgitation remains common in repaired ToF (rToF), often leading to right or left ventricular dysfunction and reduced exercise capacity. CPET is a reliable tool for evaluating cardiopulmonary function. Although both treadmill and cycle ergometer protocols are used interchangeably, reference value ranges for each method in this population remain unclear. METHOD: CPET data were collected from asymptomatic rToF patients who had undergone cardiac magnetic resonance imaging (CMR) and performed CPET on a treadmill or cycle ergometer between 2020 and 2024. Physical activity was assessed using the International Physical Activity Questionnaire (IPAQ). RESULTS: Among 290 patients, median age at CPET was 21.6 years (15.9-29.3), and median BMI was 22.5 kg/m(2) (20.0-24.9). Nearly all participants (99%) were in NYHA class I. Physical activity was classified as sedentary in 29%, moderate in 61%, and high in 9%. Median VO(2) peak was 26.4 mL/min/kg (23.0-31.5), corresponding to 72.9% predicted (62.4-83.2). Median oxygen pulse at peak was 9.9 mL/beat (8.2-12.0), with 76.9% predicted (68.0-87.5). Median VE/VCO(2) slope at the respiratory compensation point was 29.0 (26.0-32.6), and median oxygen uptake efficiency slope (OUES) was 1,792.5 mL/min/log(L/min) (1,535.0-2,181.5). VO(2) peak and percent-predicted VO(2) were significantly higher with treadmill testing in both sexes (p < 0.05); oxygen pulse was higher only in females. VE/VCO(2) slope and OUES were unaffected by modality. When stratified by age (<18 vs. >/=18 years), treadmill-related differences in VO(2) peak and percent-predicted VO(2) remained significant in both sexes >/=18 years, and in females <18 years. Oxygen pulse was significantly higher with treadmill only in females >/=18 years. VE/VCO(2) slope and OUES remained unchanged across modalities and age groups. CONCLUSION: This study provides CPET values stratified by modality and sex in a large cohort of asymptomatic rToF patients, offering valuable reference data for clinical assessment. Future studies should validate pediatric normative CPET values through prospective, inclusive, statistically powered cohorts using standardized protocols and cross-center comparability. CI - (c) 2026 Leonardi, Gentili, Tranchita, Montanaro, Butera, Palmieri, Di Gia, Secinaro, Antonelli, Lioncino and Giordano. FAU - Leonardi, Benedetta AU - Leonardi B AD - Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Gentili, Federica AU - Gentili F AD - Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Tranchita, Eliana AU - Tranchita E AD - Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Montanaro, Claudia AU - Montanaro C AD - Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Butera, Gianfranco AU - Butera G AD - Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Palmieri, Rosalinda AU - Palmieri R AD - Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Di Gia, Giulia AU - Di Gia G AD - Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Secinaro, Aurelio AU - Secinaro A AD - Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Antonelli, Giovanni AU - Antonelli G AD - Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Lioncino, Michele AU - Lioncino M AD - Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Giordano, Ugo AU - Giordano U AD - Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. LA - eng PT - Journal Article DEP - 20260421 PL - Switzerland TA - Front Cardiovasc Med JT - Frontiers in cardiovascular medicine JID - 101653388 PMC - PMC13139358 OTO - NOTNLM OT - Tetralogy of Fallot OT - VE/VCO(2) slope OT - VO2 peak OT - cardiopulmonary test OT - cyclo-ergometer OT - treadmil COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors BL, CM, GB declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/05/07 06:35 MHDA- 2026/05/07 06:36 PMCR- 2026/04/21 CRDT- 2026/05/07 05:21 PHST- 2025/07/25 00:00 [received] PHST- 2026/02/08 00:00 [revised] PHST- 2026/02/23 00:00 [accepted] PHST- 2026/05/07 06:36 [medline] PHST- 2026/05/07 06:35 [pubmed] PHST- 2026/05/07 05:21 [entrez] PHST- 2026/04/21 00:00 [pmc-release] AID - 10.3389/fcvm.2026.1673478 [doi] PST - epublish SO - Front Cardiovasc Med. 2026 Apr 21;13:1673478. doi: 10.3389/fcvm.2026.1673478. eCollection 2026. PMID- 42094888 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Optimal dose of aerobic exercise for improving postpartum depression, anxiety, and quality of life: a meta-analysis of randomized controlled trials and dose-response analysis. PG - 1807903 LID - 10.3389/fpubh.2026.1807903 [doi] LID - 1807903 AB - BACKGROUND: Postpartum depression, anxiety, and reduced health related quality of life (HRQoL) are common in the first year after childbirth, a period characterized by marked hormonal fluctuations, sleep disruption, and psychosocial role transitions that increase vulnerability to emotional distress, and have substantial consequences for maternal and child well-being. Aerobic exercise is increasingly recommended as a low-risk behavioral strategy, as it has been shown to improve mood, reduce stress, and modulate neurobiological pathways associated with depression, yet its effectiveness and optimal prescription parameters for postpartum mental health remain unclear. This study evaluated the effects of aerobic exercise on depressive symptoms, anxiety, and HRQoL, and characterized corresponding dose response patterns. METHODS: PubMed, Embase, CENTRAL, Web of Science, and Google Scholar were searched from inception to 31 October 2025. Randomized controlled trials lasting at least four weeks and comparing structured aerobic exercise with inactive or minimal control conditions were included. Outcomes were depressive symptoms, anxiety, and HRQoL assessed using validated instruments. Random effects meta-analyses generated standardized mean differences (SMDs). Dose response relationships were examined using model-based methods. RESULTS: Seventeen trials involving 2,865 women met inclusion criteria. Aerobic exercise significantly reduced depressive symptoms (SMD - 0.37, 95% CI - 0.60 to -0.14), with larger improvements in women with baseline depression and in interventions delivered postpartum. Dose response analysis showed a U-shaped pattern, with maximal benefit at approximately 570 MET minutes per week. No significant effect was found for anxiety (SMD - 0.11, 95% CI - 0.31 to 0.09). Aerobic exercise improved HRQoL (SMD 0.45, 95% CI 0.29 to 0.60), and an inverted U-shaped dose response indicated optimal gains near 420 MET minutes per week. CONCLUSION: Aerobic exercise reduces postpartum depressive symptoms and improves HRQoL. Optimal effects were observed at approximately 570 MET minutes per week for depression and 420 MET minutes per week for HRQoL, suggesting that a weekly volume of 400 to 600 MET minutes may be a practical target in postpartum care. Evidence remains insufficient to confirm anxiolytic effects. CI - Copyright (c) 2026 Cai, Du, Huang and Yang. FAU - Cai, Luqiong AU - Cai L AD - Department of Rehabilitation, Ningbo Rehabilitation Hospital, Ningbo, China. FAU - Du, Yuqing AU - Du Y AD - Department of Rehabilitation, Ningbo Rehabilitation Hospital, Ningbo, China. FAU - Huang, Yihui AU - Huang Y AD - Ningbo Psychiatric Hospital, Ningbo, China. FAU - Yang, Renjun AU - Yang R AD - Department of Rehabilitation, Jintang First People's Hospital, Chengdu, China. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260421 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Female MH - *Depression, Postpartum/therapy/prevention & control MH - *Quality of Life/psychology MH - *Anxiety/therapy/prevention & control MH - *Exercise/psychology MH - Randomized Controlled Trials as Topic PMC - PMC13139009 OTO - NOTNLM OT - aerobic exercise OT - dose-response analysis OT - postpartum anxiety OT - postpartum depression OT - quality of life COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/07 06:35 MHDA- 2026/05/07 06:36 PMCR- 2026/04/21 CRDT- 2026/05/07 05:18 PHST- 2026/02/10 00:00 [received] PHST- 2026/03/21 00:00 [revised] PHST- 2026/03/24 00:00 [accepted] PHST- 2026/05/07 06:36 [medline] PHST- 2026/05/07 06:35 [pubmed] PHST- 2026/05/07 05:18 [entrez] PHST- 2026/04/21 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1807903 [doi] PST - epublish SO - Front Public Health. 2026 Apr 21;14:1807903. doi: 10.3389/fpubh.2026.1807903. eCollection 2026. PMID- 42094680 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260507 LR - 20260813 IS - 2673-4842 (Electronic) IS - 2673-4842 (Linking) VI - 7 DP - 2026 TI - Salivary pH within multifactorial caries risk assessment in children: observational clinical evidence using the Cariogram platform. PG - 1822466 LID - 10.3389/froh.2026.1822466 [doi] LID - 1822466 AB - INTRODUCTION: Dental caries is a multifactorial disease influenced by biological, behavioral, and preventive factors. Salivary pH has been proposed as a non-invasive biomarker for caries risk assessment, however, its independent clinical relevance within structured digital risk models remains unclear. This study school-aged pediatric cohort using the Cariogram platform as a structured, multifactorial caries risk assessment tool, and to evaluate the role of digitally measured salivary pH in relation to caries risk stratification and clinical caries indicators within this framework. METHODS: A total of 66 children aged 6-12 years were included. Unstimulated salivary pH was measured using both a digital pH meter and colorimetric strips. Caries risk was assessed using the Cariogram platform. Agreement between pH measurement methods was evaluated using Bland-Altman analysis. Associations between salivary pH, dietary intake frequency, and caries risk were explored using Spearman's rank correlation. A multivariable linear regression model was constructed using the Cariogram-derived chance to avoid new caries (%) as the dependent variable, including mean digitally measured salivary pH, dietary intake frequency, oral hygiene status, fluoride toothpaste use, age, gender, and saliva collection timing as predictors. RESULTS: Digital salivary pH values ranged from 6.1 to 7.2, with a peak between 6.6 and 6.8. Strip-based measurements systematically underestimated pH, with a mean bias of approximately 0.24 pH units. Salivary pH showed weak or negligible associations with Cariogram risk categories. In the multivariable model, dietary intake frequency, oral hygiene status, fluoride toothpaste use, and saliva collection timing were significant predictors of caries risk, whereas salivary pH was not independently associated after adjustment for behavioral and preventive factors. CONCLUSIONS: Salivary pH is a biologically relevant but insufficient standalone marker of caries risk in children. Its clinical value emerges when measured reliably and interpreted within a multifactorial, caries risk-assessment framework supported by digital tools, particularly the Cariogram platform and digital pH measurement. CI - (c) 2026 Barbulescu, Cristache, Vacarel and Nimigean. FAU - Barbulescu, Eliza Denisa AU - Barbulescu ED AD - Doctoral School, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. FAU - Cristache, Corina Marilena AU - Cristache CM AD - Department of Dental Techniques, Faculty of Midwifery and Nursing, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. FAU - Vacarel, Elena Valentina AU - Vacarel EV AD - Doctoral School, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. FAU - Nimigean, Vanda Roxana AU - Nimigean VR AD - Department of Oral Rehabilitation, Faculty of Dentistry, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. LA - eng PT - Journal Article DEP - 20260421 PL - Switzerland TA - Front Oral Health JT - Frontiers in oral health JID - 9918227262706676 PMC - PMC13139144 OTO - NOTNLM OT - Cariogram OT - caries risk assessment OT - digital diagnostics OT - pediatric dentistry OT - preventive dentistry COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author CC declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/05/07 06:37 MHDA- 2026/05/07 06:38 PMCR- 2026/04/21 CRDT- 2026/05/07 05:15 PHST- 2026/03/03 00:00 [received] PHST- 2026/03/25 00:00 [revised] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/05/07 06:38 [medline] PHST- 2026/05/07 06:37 [pubmed] PHST- 2026/05/07 05:15 [entrez] PHST- 2026/04/21 00:00 [pmc-release] AID - 10.3389/froh.2026.1822466 [doi] PST - epublish SO - Front Oral Health. 2026 Apr 21;7:1822466. doi: 10.3389/froh.2026.1822466. eCollection 2026. PMID- 42093187 OWN - NLM STAT- MEDLINE DCOM- 20260720 LR - 20260720 IS - 1872-6623 (Electronic) IS - 0304-3959 (Linking) VI - 167 IP - 8 DP - 2026 Aug 1 TI - The role of physical activity in children and adolescents with chronic pain: the moderating effects of psychological symptoms and sleep difficulties. PG - 1824-1838 LID - 10.1097/j.pain.0000000000003997 [doi] AB - Chronic pain in children and adolescents affects physical, psychological, social, and academic function. Although physical activity may play a role, its direct effects and its interactions with sleep difficulties and psychological symptoms remain unclear. This cross-sectional study examined whether physical activity is associated with chronic pain, and whether these associations vary by sleep difficulties and psychological symptoms. We analyzed data from 212,105 individuals (49% girls, age: 11-15 years) from the 2018 Health Behavior in School-aged Children study. Chronic pain, psychological symptoms, sleep difficulties, moderate-to-vigorous physical activity (MVPA), and vigorous physical activity (VPA) were assessed using validated self-report measures. Three multivariate logistic regression models (for chronic back pain, stomachache, and headache) examined main and moderation effects, adjusting for age, gender identity, and socioeconomic status. In adjusted main-effects models, higher MVPA was associated with higher odds of chronic back pain (aOR 1.15, 95% CI 1.06-1.25) and stomachache (aOR 1.02, 95% CI 1.00-1.09) but not headache. Interaction models indicated that MVPA associations differed by sleep difficulties, and the VPA-pain association differed by psychological symptoms. In stratified analyses, several MVPA frequency categories (vs 0 d/wk) were associated with lower odds of back pain and stomachache in both low and high sleep-difficulty groups. Vigorous physical activity was associated with lower odds of back pain and stomachache among adolescents with moderate or high psychological symptoms but not those with low symptom frequency. Overall, physical activity was not uniformly protective; associations were pain-type specific and varied according to adolescents sleep and psychological profiles. CI - Copyright (c) 2026 International Association for the Study of Pain. FAU - Ceniza-Bordallo, Guillermo AU - Ceniza-Bordallo G AUID- ORCID: 0000-0003-3012-666 AD - Department of Psychiatry, Center for Health Outcomes and Interdisciplinary Research, Massachusetts General Hospital, Boston, MA, United States. AD - Department of Psychiatry, Harvard Medical School, Boston, MA, United States. FAU - Sanchez-Rodriguez, Elisabet AU - Sanchez-Rodriguez E AD - Unit for the Study and Treatment of Pain-ALGOS, Research Center for Behavior Assessment (CRAMC), Department of Psychology, Universitat Rovira i Virgili, Catalonia, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili, Universitat Rovira i Virgili, Catalonia, Spain. FAU - Roman-Juan, Josep AU - Roman-Juan J AD - Department of Psychology, University of Calgary, Calgary, AB, Canada. FAU - Jensen, Mark P AU - Jensen MP AD - Department of Rehabilitation Medicine, University of Washington, Seattle, WA, United States. FAU - Miro, Jordi AU - Miro J AUID- ORCID: 0000-0002-1998-6653 AD - Unit for the Study and Treatment of Pain-ALGOS, Research Center for Behavior Assessment (CRAMC), Department of Psychology, Universitat Rovira i Virgili, Catalonia, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili, Universitat Rovira i Virgili, Catalonia, Spain. LA - eng PT - Journal Article DEP - 20260507 PL - United States TA - Pain JT - Pain JID - 7508686 SB - IM MH - Humans MH - Female MH - Child MH - Adolescent MH - *Chronic Pain/psychology/epidemiology/physiopathology MH - Male MH - *Sleep Wake Disorders/psychology/epidemiology MH - Cross-Sectional Studies MH - *Exercise/psychology/physiology OTO - NOTNLM OT - Biopsychosocial model OT - Pediatric chronic pain OT - Physical activity OT - Psychological symptoms OT - Sleep difficulties EDAT- 2026/05/07 06:38 MHDA- 2026/07/20 12:40 CRDT- 2026/05/07 02:03 PHST- 2025/03/22 00:00 [received] PHST- 2026/03/15 00:00 [accepted] PHST- 2026/07/20 12:40 [medline] PHST- 2026/05/07 06:38 [pubmed] PHST- 2026/05/07 02:03 [entrez] AID - 00006396-202608000-00015 [pii] AID - 10.1097/j.pain.0000000000003997 [doi] PST - ppublish SO - Pain. 2026 Aug 1;167(8):1824-1838. doi: 10.1097/j.pain.0000000000003997. Epub 2026 May 7. PMID- 42090986 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1878-7487 (Electronic) IS - 1752-928X (Linking) VI - 120 DP - 2026 May TI - AgeMiner: A novel metadata-integrated chronological age predictor based on bone mineral density data. PG - 103149 LID - S1752-928X(26)00081-8 [pii] LID - 10.1016/j.jflm.2026.103149 [doi] AB - The estimation of chronological age based on bone mineral density (BMD) metrics for specific anatomical sites is a critical task in forensic anthropology. Although dual-energy X-ray absorptiometry (DXA) scans of the distal 1/3 of radius and ulna are widely used in large-scale osteoporosis screenings, forensic studies leveraging such data remain scarce. This study utilized a retrospective dataset (spanning ages 12-96) of 5,134 DXA scans from the distal 1/3 radius and ulna. We analyzed these DXA scans with metadata, including sex, body mass index (BMI), and osteoporosis diagnoses, to train machine learning models. Linear regression (LR), support vector regression (SVR), random forest regression (RFR), XGBoost (XGB), and LightGBM (LGBM) models were optimized via Bayesian cross-validation. Results indicate that the simplest model constructed solely based on BMD data + Diagnoses showed good performance with a mean absolute error (MAE) of 2.40 years. The best-performing model was the RFR model built using the combination of Female + Diagnoses, with an MAE of 2.18 years. When only considering BMI, the best model was the RFR model for the Normal weight + Diagnoses combination, with an MAE of 2.54 years. These models have been integrated into the AgeMiner tool (https://github.com/Rarapie/AgeMiner), allowing forensic users to select the optimal model according to metadata of the tested person, thereby enabling fast and end-to-end chronological age estimation. In summary, AgeMiner and its integrated ML models provide an efficient, accurate, and customizable tool for forensic age estimation in adults and the elderly. CI - Copyright (c) 2026 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved. FAU - Lei, Fanzhang AU - Lei F AD - Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, 510515, China. FAU - Wang, Yuanyuan AU - Wang Y AD - Department of Health Management, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. FAU - Yuan, Xi AU - Yuan X AD - Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, 510515, China. FAU - Wu, Chengkai AU - Wu C AD - School of Public Health, Southern Medical University, Guangzhou, 510515, China; School of Health Management, Southern Medical University, Guangzhou, 510515, China; Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. FAU - Fu, Jing AU - Fu J AD - Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. FAU - Mao, Chen AU - Mao C AD - Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, 510515, China. Electronic address: maochen9@smu.edu.cn. FAU - Zhu, Bofeng AU - Zhu B AD - Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, 510515, China. Electronic address: zhubofeng@i.smu.edu.cn. LA - eng PT - Journal Article DEP - 20260417 PL - England TA - J Forensic Leg Med JT - Journal of forensic and legal medicine JID - 101300022 SB - IM MH - Humans MH - *Age Determination by Skeleton/methods MH - Female MH - *Bone Density MH - Aged, 80 and over MH - Child MH - Absorptiometry, Photon MH - Adolescent MH - Middle Aged MH - Aged MH - Adult MH - Retrospective Studies MH - Male MH - Young Adult MH - Body Mass Index MH - Boosting Machine Learning Algorithms MH - Random Forest MH - Linear Models MH - Ulna/diagnostic imaging MH - Radius/diagnostic imaging MH - *Machine Learning MH - Osteoporosis MH - Forensic Anthropology MH - Bayes Theorem MH - *Metadata MH - Support Vector Machine OTO - NOTNLM OT - Age estimation OT - Bone mineral density OT - Dual-energy X-ray absorptiometry OT - Forensic anthropology OT - Machine learning COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/07 00:33 MHDA- 2026/05/31 05:33 CRDT- 2026/05/06 18:08 PHST- 2025/09/14 00:00 [received] PHST- 2025/12/25 00:00 [revised] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/05/31 05:33 [medline] PHST- 2026/05/07 00:33 [pubmed] PHST- 2026/05/06 18:08 [entrez] AID - S1752-928X(26)00081-8 [pii] AID - 10.1016/j.jflm.2026.103149 [doi] PST - ppublish SO - J Forensic Leg Med. 2026 May;120:103149. doi: 10.1016/j.jflm.2026.103149. Epub 2026 Apr 17. PMID- 42088677 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260506 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Translation, cross-cultural adaptation and psychometric validation of the self-efficacy scale for physical education teacher education majors toward children with disabilities for Brazilian Portuguese. PG - 1782205 LID - 10.3389/fpsyg.2026.1782205 [doi] LID - 1782205 AB - INTRODUCTION: The participation of people with disabilities (PWD) in physical activity and sports is essential for social inclusion and health promotion. The self-efficacy perceived by professionals greatly influences the success of inclusive practices; higher confidence in adapting activities and addressing diverse needs leads to better experiences for PWD. The self-efficacy scale for physical education teacher education majors toward children with disabilities (SE-PETE-D) measures this construct but lacked a validated Brazilian version. OBJECTIVE: To translate, culturally adapt, and validate the Brazilian Portuguese version, named EAE-EFI/Brazil. RESULTS: Content validity indices exceeded 0.90 across all subscales. Exploratory factor analysis revealed high internal consistency (Cronbach's alpha > 0.96). Confirmatory factor analysis showed acceptable model fit (RMSEA <0.10; CFI, TLI, IFI > 0.90), supporting the original structure for subscales related to physical disability (PD) and visual impairment (VI). CONCLUSION: The EAE-EFI/Brazil is a valid and reliable tool for assessing physical education teachers' and students' self-efficacy concerning inclusion of individuals with intellectual disabilities, PD, and VI in Brazil. Future studies should evaluate the scale's applicability in diverse contexts and explore links with professional development and institutional support, advancing inclusive practices and policies in Brazilian education. CI - Copyright (c) 2026 Guerreiro, Winckler, Almeida, Block and Silva. FAU - Guerreiro, Renato de Carvalho AU - Guerreiro RC AD - Universidade Federal de Juiz de Fora - UFJF, Governador Valadares, Brazil. AD - Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil. AD - Comite Paralimpico Brasileiro, Sao Paulo, Brazil. FAU - Winckler, Ciro AU - Winckler C AD - Universidade Federal de Sao Paulo - UNIFESP, Sao Paulo, Brazil. FAU - de Almeida, Raphael Moreira AU - de Almeida RM AD - Universidade Federal de Sao Paulo - UNIFESP, Sao Paulo, Brazil. FAU - Block, Martin E AU - Block ME AD - University of Virginia, Charlottesville, VA, United States. FAU - Silva, Andressa AU - Silva A AD - Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil. LA - eng PT - Journal Article DEP - 20260420 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13136146 OTO - NOTNLM OT - EAE-EFI/Brazil OT - SE-PETE-D OT - cross-cultural adaptation OT - inclusive physical education OT - physical education teacher OT - professional development OT - self-efficacy scale OT - special educational needs COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/06 06:37 MHDA- 2026/05/06 06:38 PMCR- 2026/04/20 CRDT- 2026/05/06 05:03 PHST- 2026/01/06 00:00 [received] PHST- 2026/03/22 00:00 [revised] PHST- 2026/04/01 00:00 [accepted] PHST- 2026/05/06 06:38 [medline] PHST- 2026/05/06 06:37 [pubmed] PHST- 2026/05/06 05:03 [entrez] PHST- 2026/04/20 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1782205 [doi] PST - epublish SO - Front Psychol. 2026 Apr 20;17:1782205. doi: 10.3389/fpsyg.2026.1782205. eCollection 2026. PMID- 42086263 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 5 DP - 2026 May 5 TI - Comparing the Asia-Pacific Colorectal Screening and adjusted Asia-Pacific Colorectal Screening scores for risk stratification of advanced colorectal neoplasia in asymptomatic Vietnamese: a cross-sectional study. PG - e102941 LID - 10.1136/bmjopen-2025-102941 [doi] LID - e102941 AB - OBJECTIVE: The Asia-Pacific Colorectal Screening (APCS) score is a validated tool for predicting advanced colorectal neoplasia (ACN) in the Asia-Pacific region. An adjusted APCS (A-APCS) score was recently developed by incorporating body mass index into the original score and was reported to outperform the original score but lacked external validation. This study aimed to compare the A-APCS score with the original APCS score in asymptomatic Vietnamese individuals. DESIGN: A cross-sectional study. SETTING: Dai Phuoc Polyclinic, Ho Chi Minh City, Vietnam. PARTICIPANTS: Asymptomatic individuals underwent colonoscopy screening. OUTCOME MEASURES: Participants were categorised into three risk groups based on the sum of the APCS and A-APCS scores: average risk (AR), moderate risk (MR) and high risk (HR). The performance of the two scores was compared via receiver operating characteristic (ROC) analysis and McNemar tests. RESULTS: A total of 714 participants (median age 51 years, range: 18-79; female-to-male ratio: 1:1.46) were included, with an ACN prevalence of 9.0%. Both scores indicated effective predictive ability for ACN in the HR group compared with the AR group, with OR=3.878 (95% CI 1.777 to 8.068) and 3.266 (95% CI 1.617 to 6.595), respectively. The A-APCS score was more effective than the APCS score in predicting ACN in the MR group than in the AR group. However, no significant differences in area under the ROC curve were observed between the two scores for ACN prediction. CONCLUSIONS: Compared with the APCS score, the A-APCS score may not provide improved ACN risk stratification in asymptomatic Vietnamese individuals. Both scores are suboptimal and should be used to prioritise, rather than exclude, candidates for colonoscopy. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Quach, Duc Trong AU - Quach DT AUID- ORCID: 0000-0003-0141-921X AD - Department of Internal Medicine and Gastro-Hepato Integrated Research Team (GHIRT-002.TCM2025), University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam drquachtd@gmail.com. AD - Department of Gastroenterology, Nhan Dan Gia Dinh Hospital, Ho Chi Minh City, Viet Nam. FAU - Vu, Nhu Thi Hanh AU - Vu NTH AUID- ORCID: 0000-0003-4208-7813 AD - Department of Internal Medicine and Gastro-Hepato Integrated Research Team (GHIRT-002.TCM2025), University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam. FAU - To, Huong Thi Thuy AU - To HTT AD - Dai Phuoc Polyclinic, Ho Chi Minh City, Viet Nam. FAU - Tong, Hong Nguyen Diem AU - Tong HND AD - Dai Phuoc Polyclinic, Ho Chi Minh City, Viet Nam. FAU - Nguyen, Dao Thi Anh AU - Nguyen DTA AD - Dai Phuoc Polyclinic, Ho Chi Minh City, Viet Nam. FAU - Phan, Thu Dang Anh AU - Phan TDA AD - Department of Histology-Embryology and Pathology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam. FAU - Ngo, Dat Quoc AU - Ngo DQ AD - Department of Histology-Embryology and Pathology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam. FAU - Hiyama, Toru AU - Hiyama T AD - Health Service Center, Hiroshima University, Higashihiroshima, Japan. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260505 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Colorectal Neoplasms/diagnosis/epidemiology MH - Male MH - Female MH - Vietnam/epidemiology MH - Middle Aged MH - Adult MH - Colonoscopy MH - *Early Detection of Cancer/methods MH - Risk Assessment/methods MH - Aged MH - ROC Curve MH - Adolescent MH - Young Adult MH - Mass Screening/methods PMC - PMC13150889 OTO - NOTNLM OT - Early Detection of Cancer OT - Gastrointestinal tumours OT - Risk Assessment COIS- Competing interests: None declared. EDAT- 2026/05/06 00:35 MHDA- 2026/05/06 00:36 PMCR- 2026/05/05 CRDT- 2026/05/05 20:42 PHST- 2026/05/06 00:36 [medline] PHST- 2026/05/06 00:35 [pubmed] PHST- 2026/05/05 20:42 [entrez] PHST- 2026/05/05 00:00 [pmc-release] AID - bmjopen-2025-102941 [pii] AID - 10.1136/bmjopen-2025-102941 [doi] PST - epublish SO - BMJ Open. 2026 May 5;16(5):e102941. doi: 10.1136/bmjopen-2025-102941. PMID- 42085476 OWN - NLM STAT- MEDLINE DCOM- 20260824 LR - 20260918 IS - 1525-6073 (Electronic) IS - 0742-0528 (Linking) VI - 43 IP - 9 DP - 2026 Sep TI - Machine learning approaches in predicting circadian rhythm sleep-wake disorders: A review. PG - 1316-1331 LID - 10.1080/07420528.2026.2667404 [doi] AB - Circadian rhythm sleep-wake disorders (CRSWDs) arise from misalignment between an individual's sleep-wake timing and endogenous circadian physiology, with substantial consequences for sleep health and overall well-being. In the era of sleep-omics and digital phenotyping, machine learning (ML) offers powerful tools for modelling complex, high-dimensional circadian data; however, its application to CRSWD prediction remains under developed. This systematic review aims to synthesize current evidence on the use of ML approaches for circadian phase estimation and CRSWD classification in humans. We have conducted a systematic search of PubMed, ScienceDirect, PsycINFO, Cochrane Library, and Google Scholar for studies published between January 2011 and May 2025. Eligible studies focused on sighted adults where ML algorithms predicted circadian phase or classified CRSWDs. Data sources included sleep diaries, actigraphy, genomics, and biological markers. To maintain model homogeneity and account for physiological differences, studies involving pediatric populations, neurodegenerative comorbidities, or blind individuals were excluded. A total of 22 studies met the inclusion criteria. Across studies, ML models demonstrated promise for circadian phase estimation and CRSWD classification using diverse data modalities, including wearable-derived time-series data and multimodal features. However, the evidence base remains limited by small sample sizes, methodological heterogeneity, limited external validation, and inconsistent reporting standards. Overall, current findings suggest that while ML-based approaches hold significant potential for advancing CRSWD detection and personalized circadian medicine, more robust, standardized, and generalizable models are required. Future research should prioritize larger multimodal datasets, transparent validation strategies, and clinically translatable tools to support scalable CRSWD screening and diagnosis. FAU - Sengupta, Trina AU - Sengupta T AUID- ORCID: 0000-0002-1332-9425 AD - Department of Physiology, ESI-PGIMSR Medical College and Hospital, Kolkata, India. FAU - Gaur, Archana AU - Gaur A AUID- ORCID: 0000-0002-1380-4679 AD - Department of Physiology, All India Institute of Medical Sciences, Hyderabad, India. FAU - Varatharajan, Sakthivadivel AU - Varatharajan S AD - Department of Medicine, All India Institute of Medical Sciences, Hyderabad, India. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260505 PL - England TA - Chronobiol Int JT - Chronobiology international JID - 8501362 SB - IM MH - Humans MH - *Machine Learning MH - *Circadian Rhythm/physiology MH - *Sleep Disorders, Circadian Rhythm/physiopathology/diagnosis MH - *Sleep/physiology MH - Predictive Learning Models MH - *Sleep Wake Disorders/physiopathology/diagnosis MH - Prediction Algorithms OTO - NOTNLM OT - Circadian rhythm sleep wake disorder OT - Sleepomics OT - advanced phase sleep wake disorder OT - delayed phase sleep wake disorder OT - machine learning algorithm OT - predictive models EDAT- 2026/05/05 18:32 MHDA- 2026/08/24 05:34 CRDT- 2026/05/05 13:43 PHST- 2026/08/24 05:34 [medline] PHST- 2026/05/05 18:32 [pubmed] PHST- 2026/05/05 13:43 [entrez] AID - 10.1080/07420528.2026.2667404 [doi] PST - ppublish SO - Chronobiol Int. 2026 Sep;43(9):1316-1331. doi: 10.1080/07420528.2026.2667404. Epub 2026 May 5. PMID- 42081800 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260905 IS - 2292-9495 (Electronic) IS - 2292-9495 (Linking) VI - 13 DP - 2026 May 4 TI - High Screen Exposure and Its Association With Physical and Mental Well-Being Among School-Going Children and Adolescents in Bangladesh: Cross-Sectional Study. PG - e73524 LID - 10.2196/73524 [doi] LID - e73524 AB - BACKGROUND: In Bangladesh, as well as throughout the world, children's screen time has significantly increased. Children spend a lot of time on the internet and digital screens for entertainment, education, and communication, which has increased their daily screen time. However, the potential detrimental impacts of excessive screen time on children's mental, physical, and social health have drawn attention. OBJECTIVE: This study aimed to explore the effect of high exposure to screens on the health and mental well-being of school-going children and adolescents in Dhaka, Bangladesh. METHODS: This cross-sectional descriptive study was conducted from July 2022 to June 2024. A total of 420 school-going children and adolescents aged 6 to 14 years were enrolled from 3 English-language and 3 Bangla-language schools in Dhaka using a stratified random sampling technique. Anthropometric measurements, a semistructured questionnaire, and the Pittsburgh Sleep Quality Index, the Development and Well-Being Assessment scale, and the Strengths and Difficulties Questionnaire, all of which were validated in Bangla, were used to gather data. We considered students who were exposed to screens for less than 2 hours a day as the low-exposure group and those who were exposed for more than 2 hours a day as the high-exposure group. RESULTS: A total of 83.3% (350/420) of the students were in the high-exposure group, and their average screen time per day was 4.6 (SD 2.3) hours. Eye problems were reported by 35.7% (150/420) of the students, and a significant difference was found between the low- and high-exposure groups. In total, 96% (144/150) of the students with eye problems were from the high-exposure group, whereas 4% (6/150) were from the low-exposure group. Headaches were reported by 80% (336/420) of the students, and they were common in the high-exposure group (279/336, 83%). Moreover, students from the high-exposure group had a short duration and poor quality of sleep (mean 7.3, SD 1.4 hours), which was statistically significant. Furthermore, obesity was more predominant in the high-exposure group (P<.001). Our study revealed that, overall, 31% (130/420) of the students had at least one mental health problem and 9.8% (41/420) had more than one mental health problem using the Development and Well-Being Assessment scale, and mental health problems were greater in the high-exposure group than the low-exposure group. Although behavioral problems such as conduct issues (119/420, 28.3%) and peer difficulties (121/420, 28.8%) were observed among the participants, no statistically significant difference was found between the 2 groups. CONCLUSIONS: A collaborative and coordinated multistage approach is essential to create effective and acceptable guidelines and policies for the optimum and positive use of digital screens for the children of Bangladesh. Further prospective studies on a larger scale can be conducted to determine the impacts of screen time on aspects of health. CI - (c) Shahria Hafiz Kakon, Tanjir Rashid Soron, Mohammad Sharif Hossain, Biplob Hossain, Fahmida Tofail, Rashidul Haque. Originally published in JMIR Human Factors (https://humanfactors.jmir.org). FAU - Kakon, Shahria Hafiz AU - Kakon SH AUID- ORCID: 0000-0002-1127-4993 AD - icddr,b, 68, Shaheed Tajuddin Ahmed Sarani. Mohakhali, Dhaka, 1212, Bangladesh, 880 1726428760. FAU - Soron, Tanjir Rashid AU - Soron TR AUID- ORCID: 0000-0001-9810-5000 AD - Tele psychiatry Research and Innovation Network Ltd, Dhaka, Bangladesh. FAU - Hossain, Mohammad Sharif AU - Hossain MS AUID- ORCID: 0000-0002-9876-7722 AD - icddr,b, 68, Shaheed Tajuddin Ahmed Sarani. Mohakhali, Dhaka, 1212, Bangladesh, 880 1726428760. FAU - Hossain, Biplob AU - Hossain B AUID- ORCID: 0000-0002-4934-9866 AD - icddr,b, 68, Shaheed Tajuddin Ahmed Sarani. Mohakhali, Dhaka, 1212, Bangladesh, 880 1726428760. FAU - Tofail, Fahmida AU - Tofail F AUID- ORCID: 0000-0003-2301-9196 AD - icddr,b, 68, Shaheed Tajuddin Ahmed Sarani. Mohakhali, Dhaka, 1212, Bangladesh, 880 1726428760. FAU - Haque, Rashidul AU - Haque R AUID- ORCID: 0000-0001-5100-136X AD - icddr,b, 68, Shaheed Tajuddin Ahmed Sarani. Mohakhali, Dhaka, 1212, Bangladesh, 880 1726428760. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260504 PL - Canada TA - JMIR Hum Factors JT - JMIR human factors JID - 101666561 SB - IM MH - Humans MH - Bangladesh/epidemiology MH - Cross-Sectional Studies MH - Child MH - *Screen Time MH - Adolescent MH - Female MH - Male MH - *Mental Health/statistics & numerical data MH - *Students/statistics & numerical data/psychology MH - Psychological Well-Being MH - Media Exposure MH - Schools MH - Surveys and Questionnaires MH - Digital Media PMC - PMC13138789 OTO - NOTNLM OT - Bangladesh OT - Development and Well-Being Assessment scale OT - Pittsburgh Sleep Quality Index OT - Strengths and Difficulties Questionnaire OT - high exposure OT - screen time COIS- Conflicts of Interest: None declared. EDAT- 2026/05/04 18:33 MHDA- 2026/05/04 18:34 PMCR- 2026/05/04 CRDT- 2026/05/04 16:53 PHST- 2025/03/06 00:00 [received] PHST- 2026/02/13 00:00 [revised] PHST- 2026/02/19 00:00 [accepted] PHST- 2026/05/04 18:34 [medline] PHST- 2026/05/04 18:33 [pubmed] PHST- 2026/05/04 16:53 [entrez] PHST- 2026/05/04 00:00 [pmc-release] AID - v13i1e73524 [pii] AID - 73524 [pii] AID - 10.2196/73524 [doi] PST - epublish SO - JMIR Hum Factors. 2026 May 4;13:e73524. doi: 10.2196/73524. PMID- 42081744 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260910 IS - 2291-5222 (Electronic) IS - 2291-5222 (Linking) VI - 14 DP - 2026 May 4 TI - Traditional Social Sports Games and Mental Training for Smartphone Addiction and Psychological Distress in School-Aged Adolescents: Randomized Controlled Trial. PG - e85353 LID - 10.2196/85353 [doi] LID - e85353 AB - BACKGROUND: Problematic smartphone use among adolescents is a growing public health concern closely associated with psychological distress and loneliness. Effective, culturally grounded, school-based interventions are needed. OBJECTIVE: The aim of this study was to assess the effects of a 12-week program combining traditional social sports games and mental exercises on smartphone addiction, nomophobia, psychological distress, and loneliness in adolescents. METHODS: In this randomized controlled trial, 69 school-recruited Tunisian adolescents (aged 14-16 years) with clinically elevated smartphone addiction scores were assigned to an experimental group (n=36, 52.2%) or a control group (n=33, 47.8%). The experimental group received a 12-week intervention comprising 4 weekly sessions integrating traditional social sports games with mental exercises, whereas the control group continued standard physical education. Outcomes (smartphone addiction, nomophobia, psychological distress, and loneliness) were assessed at baseline and after the intervention using scales validated in Arabic. RESULTS: Linear mixed-effects models adjusted for age, sex, and BMI revealed significant group x time interactions of moderate magnitude across all outcomes (P<.05 in all cases) favoring the experimental group. Adjusted postintervention comparisons confirmed significantly lower scores in the experimental group for smartphone addiction, nomophobia, psychological distress, and loneliness (P<.05 in all cases; partial etap2=0.08-0.12). Mediation analysis indicated that reductions in loneliness accounted for 34.4% of the intervention's effect on smartphone addiction, consistent with partial mediation. CONCLUSIONS: A culturally adapted, school-based intervention combining traditional social sports games and mental exercises significantly reduced problematic smartphone use and improved psychological well-being. The partial mediation through reduced loneliness highlights the critical role of social connectedness in adolescent digital health interventions. CI - (c) Mohamed Yaakoubi, Ahmed Ghorbel, Hiba Abdelkafi, Liwa Masmoudi, Omar Trabelsi, Safaa M. Elkholi, Fatma H. Yagin, Georgian Badicu, Adnene Gharbi. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org). FAU - Yaakoubi, Mohamed AU - Yaakoubi M AUID- ORCID: 0009-0003-5187-236X AD - High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia. AD - Research Unit: Physical Activity, Sport and Health, UR18JS01, National Observatory of Sport, Tunis, Tunisia. FAU - Ghorbel, Ahmed AU - Ghorbel A AUID- ORCID: 0009-0004-6890-9867 AD - High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia. AD - Research Unit: Physical Activity, Sport and Health, UR18JS01, National Observatory of Sport, Tunis, Tunisia. FAU - Abdelkafi, Hiba AU - Abdelkafi H AUID- ORCID: 0000-0002-9869-456X AD - The High Institute of Applied Studies in Humanities of Mahdia, Department of Education Sciences, University of Monastir, Mahdia, Tunis, Tunisia. FAU - Masmoudi, Liwa AU - Masmoudi L AUID- ORCID: 0000-0002-9628-1585 AD - High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia. AD - Research Unit: Physical Activity, Sport and Health, UR18JS01, National Observatory of Sport, Tunis, Tunisia. FAU - Trabelsi, Omar AU - Trabelsi O AUID- ORCID: 0009-0008-2568-3000 AD - High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia. AD - Research Unit: Physical Activity, Sport and Health, UR18JS01, National Observatory of Sport, Tunis, Tunisia. AD - The High Institute of Applied Studies in Humanities of Mahdia, Department of Education Sciences, University of Monastir, Mahdia, Tunis, Tunisia. FAU - Elkholi, Safaa M AU - Elkholi SM AUID- ORCID: 0000-0002-1100-4301 AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Riyadh, 84428, Saudi Arabia. FAU - Yagin, Fatma H AU - Yagin FH AUID- ORCID: 0000-0002-9848-7958 AD - Department of Biostatistics, Faculty of Medicine, Malatya Turgut Ozal University, 44210, Malatya, Turkey. FAU - Badicu, Georgian AU - Badicu G AUID- ORCID: 0000-0003-4100-8765 AD - Department of Physical Education and Special Motricity, University Transilvania of Brasov, Brasov, Romania. FAU - Gharbi, Adnene AU - Gharbi A AUID- ORCID: 0000-0001-9971-1993 AD - Research Unit: Physical Activity, Sport and Health, UR18JS01, National Observatory of Sport, Tunis, Tunisia. AD - High Institute of Sports and Physical Education of Sfax, University of Sfax, Sfax, Tunisia. LA - eng SI - PACTR/PACTR202601838702413 PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20260504 PL - Canada TA - JMIR Mhealth Uhealth JT - JMIR mHealth and uHealth JID - 101624439 SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - *Psychological Distress MH - *Internet Addiction Disorder/psychology/therapy MH - Tunisia MH - Surveys and Questionnaires MH - Smartphone/statistics & numerical data MH - *Video Games/psychology/standards MH - Loneliness/psychology MH - Psychometrics/methods/instrumentation MH - Behavior, Addictive/psychology/therapy PMC - PMC13138712 OTO - NOTNLM OT - Tunisia OT - adolescents OT - loneliness OT - psychological distress OT - randomized controlled trial OT - smartphone addiction COIS- Conflicts of Interest: None declared. EDAT- 2026/05/04 18:33 MHDA- 2026/05/04 18:34 PMCR- 2026/05/04 CRDT- 2026/05/04 15:43 PHST- 2025/10/06 00:00 [received] PHST- 2026/04/02 00:00 [revised] PHST- 2026/04/09 00:00 [accepted] PHST- 2026/05/04 18:34 [medline] PHST- 2026/05/04 18:33 [pubmed] PHST- 2026/05/04 15:43 [entrez] PHST- 2026/05/04 00:00 [pmc-release] AID - v14i1e85353 [pii] AID - 85353 [pii] AID - 10.2196/85353 [doi] PST - epublish SO - JMIR Mhealth Uhealth. 2026 May 4;14:e85353. doi: 10.2196/85353. PMID- 42081240 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260923 IS - 2168-6211 (Electronic) IS - 2168-6203 (Print) IS - 2168-6203 (Linking) VI - 180 IP - 8 DP - 2026 Aug 1 TI - Risk and Protective Factors Associated With HIV-Related Mortality in Children Receiving Antiretroviral Therapy: A Model-Based Meta-Regression. PG - 829-837 LID - 10.1001/jamapediatrics.2026.1235 [doi] AB - IMPORTANCE: Mortality among children and young adolescents receiving antiretroviral therapy (ART) remains substantially higher in resource-limited settings compared with resource-rich regions. The role of modifiable risk and protective factors in explaining this global variation remains poorly understood. OBJECTIVE: To identify and quantify country-level modifiable risk and protective factors associated with HIV-related mortality among children and young adolescents receiving ART. DESIGN, SETTING, AND PARTICIPANTS: This model-based meta-regression analysis linked HIV-related mortality data from cohort studies included in a published systematic review of children and adolescents (aged 0-14 years) receiving ART, with biomedical, behavioral, and structural factors from the Global Burden of Diseases, Injuries, and Risk Factors study 2023. Data were analyzed using penalized regression (ridge regression with cross-validation) and an ensemble machine-learning algorithm (XGBoost). Study data were analyzed from August 2024 to October 2025. EXPOSURES: Country-level modifiable covariates, including access to improved water, vaccine coverage against different pathogens, maternal education, underweight proportion, and oral rehydration coverage. MAIN OUTCOMES AND MEASURES: Measures included the odds ratios (ORs) of HIV-related mortality while receiving ART associated with modifiable factors, simulations of hypothetical 10% and 20% increases in covariates, and variable importance via Shapley Additive Explanation (SHAP) values. RESULTS: HIV-related mortality data from 67 cohort studies were included in this analysis. Access to improved water, pneumococcal conjugate vaccine third-dose (PCV3) coverage, and maternal education demonstrated the strongest independent associations with HIV-related mortality while receiving ART. A 10% increase in improved water access, PCV3 coverage, and maternal education was associated with lower odds of mortality (OR, 0.83; 95% CI, 0.826-0.843; OR, 0.980; 95% CI, 0.972-0.987; and OR, 0.997; 95% CI, 0.996-0.998, respectively). At 20% increases, these protective associations with HIV-related mortality were stronger (OR, 0.695; 95% CI, 0.682-0.711; OR, 0.959; 95% CI, 0.945-0.974; and OR, 0.994; 95% CI, 0.992-0.997, respectively). SHAP-based analyses consistently ranked these 3 factors as most predictive of HIV-related mortality. CONCLUSIONS AND RELEVANCE: Findings of this model-based meta-regression analysis show that improved water access, PCV3 coverage, and maternal education were associated with lower HIV-related mortality among children receiving ART, underscoring the need for integrated public health strategies beyond ART alone. Interventions to strengthen water infrastructure, vaccination programs, and maternal education may help reduce global survival disparities among children and adolescents living with HIV and receiving ART. FAU - He, Jiawei AU - He J AD - Institute for Health Metrics and Evaluation, University of Washington, Seattle. AD - Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle. FAU - Kassanjee, Reshma AU - Kassanjee R AD - Centre for Integrated Data and Epidemiological Research, School of Public Health, University of Cape Town, Cape Town, South Africa. FAU - Movo, Amanda AU - Movo A AD - Institute for Health Metrics and Evaluation, University of Washington, Seattle. FAU - Walters, Magdalene K AU - Walters MK AD - MRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, United Kingdom. FAU - Brewer, Edmond AU - Brewer E AD - Institute for Health Metrics and Evaluation, University of Washington, Seattle. FAU - Sorensen, Reed J D AU - Sorensen RJD AD - Institute for Health Metrics and Evaluation, University of Washington, Seattle. FAU - Hay, Simon I AU - Hay SI AD - Institute for Health Metrics and Evaluation, University of Washington, Seattle. AD - Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle. FAU - Murray, Christopher J L AU - Murray CJL AD - Institute for Health Metrics and Evaluation, University of Washington, Seattle. AD - Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle. FAU - Flaxman, Abraham AU - Flaxman A AD - Institute for Health Metrics and Evaluation, University of Washington, Seattle. AD - Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle. FAU - Aravkin, Aleksandr AU - Aravkin A AD - Institute for Health Metrics and Evaluation, University of Washington, Seattle. AD - Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle. FAU - Zheng, Peng AU - Zheng P AD - Institute for Health Metrics and Evaluation, University of Washington, Seattle. AD - Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle. FAU - Kyu, Hmwe H AU - Kyu HH AD - Institute for Health Metrics and Evaluation, University of Washington, Seattle. AD - Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle. LA - eng GR - U01 AI096299/AI/NIAID NIH HHS/United States GR - U01 AI069923/AI/NIAID NIH HHS/United States GR - R01 AI152721/AI/NIAID NIH HHS/United States GR - U01 AI069911/AI/NIAID NIH HHS/United States GR - U01 AI069919/AI/NIAID NIH HHS/United States GR - U01 AI069907/AI/NIAID NIH HHS/United States GR - U01 AI069924/AI/NIAID NIH HHS/United States PT - Journal Article PT - Meta-Analysis PT - Systematic Review PL - United States TA - JAMA Pediatr JT - JAMA pediatrics JID - 101589544 RN - 0 (Anti-Retroviral Agents) RN - 0 (Anti-HIV Agents) SB - IM CIN - JAMA Pediatr. 2026 Aug 1;180(8):821-822. doi: 10.1001/jamapediatrics.2026.1277. PMID: 42081239 MH - Humans MH - *HIV Infections/mortality/drug therapy MH - Adolescent MH - Child MH - Risk Factors MH - Child, Preschool MH - Protective Factors MH - Infant MH - Female MH - Male MH - *Anti-Retroviral Agents/therapeutic use MH - *Anti-HIV Agents/therapeutic use MH - Infant, Newborn MH - Resource-Limited Settings PMC - PMC13140089 MID - NIHMS2170032 COIS- Conflict of Interest Disclosures: Dr Kassanjee reported receiving salary support from the University of Cape Town through National Institutes of Health (NIH) grants during the conduct of the study. Ms Movo reported receiving salary support from grants provided by Gates Foundation outside the submitted work. Dr Kyu reported receiving grant support from the NIH during the conduct of the study and being employed at the Institute for Health Metrics and Evaluation, which is funded by the Gates Foundation, outside the submitted work. No other disclosures were reported. EDAT- 2026/05/04 12:34 MHDA- 2026/08/03 12:42 PMCR- 2026/07/02 CRDT- 2026/05/04 11:33 PHST- 2026/08/03 12:42 [medline] PHST- 2026/05/04 12:34 [pubmed] PHST- 2026/05/04 11:33 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - 2848569 [pii] AID - 10.1001/jamapediatrics.2026.1235 [doi] PST - ppublish SO - JAMA Pediatr. 2026 Aug 1;180(8):829-837. doi: 10.1001/jamapediatrics.2026.1235. PMID- 42080686 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1998-3905 (Electronic) IS - 0970-4388 (Linking) VI - 44 IP - 2 DP - 2026 Mar 1 TI - Feeding at sleep time and early childhood caries: Validation of the feeding at sleep time (FeAST) scale in 12-36-month-old children in Bhubaneswar, Odisha. PG - 157-163 LID - 10.4103/jisppd.jisppd_1_26 [doi] AB - CONTEXT: Early childhood caries (ECC) remains a major public health concern in India, with feeding-at-sleep behaviors recognized as important behavioral risk factors. The feeding at sleep time (FeAST) scale was developed to quantify such behaviors, but its applicability across diverse Indian sociocultural settings remains uncertain. AIMS: To evaluate the external validity of the FeAST scale in identifying ECC risk among 12-36-month-old toddlers in Bhubaneswar, Odisha, and to examine the association between socioeconomic status and ECC. SETTINGS AND DESIGN: A hospital-based cross-sectional study conducted in a tertiary care teaching hospital in Bhubaneswar, Eastern India. MATERIALS AND METHODS: A total of 387 toddlers aged 12-36 months and their caregivers were recruited. Feeding behaviors were assessed using the original FeAST questionnaire, generating scores for combined breastfeeding (CBR), combined bottle-feeding (CBO), and other feeding constructs (OFC). ECC status was determined through oral examination. SES was classified using the updated B. G. Prasad Scale (2025). STATISTICAL ANALYSIS: Receiver operating characteristic analysis with a minimal cutoff score was used to determine diagnostic accuracy. Chi-square test assessed associations between ECC and SES. Statistical significance was set at P < 0.05. RESULTS: ECC prevalence was 32.9%. CBR (AUC = 0.446) and CBO (AUC = 0.481) demonstrated poor discriminatory ability, while OFC showed modest performance (AUC = 0.577). No significant association was found between ECC and SES ( P = 0.511). CONCLUSIONS: The FeAST scale demonstrated limited diagnostic validity in this Eastern Indian cohort, indicating the need for regional recalibration incorporating contextual feeding and oral hygiene behaviors. CI - Copyright (c) 2026 Journal of Indian Society of Pedodontics and Preventive Dentistry. FAU - Taraphder, Rupsa AU - Taraphder R AD - Department of Pediatric and Preventive Dentistry, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology Deemed to be University, Bhubaneswar, Odisha, India. FAU - Dutta, Brahmananda AU - Dutta B AD - Department of Pediatric and Preventive Dentistry, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology Deemed to be University, Bhubaneswar, Odisha, India. FAU - Dhull, Kanika Singh AU - Dhull KS AD - Department of Pediatric and Preventive Dentistry, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology Deemed to be University, Bhubaneswar, Odisha, India. FAU - Abbasi, Aiman Itrat AU - Abbasi AI AD - Bristol Medical School, University of Bristol, Bristol, UK. FAU - Roy, Bhaswati AU - Roy B AD - Department of Pediatric and Preventive Dentistry, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology Deemed to be University, Bhubaneswar, Odisha, India. LA - eng PT - Journal Article PT - Validation Study DEP - 20260430 PL - India TA - J Indian Soc Pedod Prev Dent JT - Journal of the Indian Society of Pedodontics and Preventive Dentistry JID - 8710631 SB - IM MH - Humans MH - India/epidemiology MH - Infant MH - *Dental Caries/epidemiology MH - Cross-Sectional Studies MH - Male MH - Female MH - *Feeding Behavior MH - Child, Preschool MH - *Sleep MH - Bottle Feeding MH - Breast Feeding MH - Surveys and Questionnaires MH - Risk Factors OTO - NOTNLM OT - Early childhood caries OT - feeding at sleep time OT - feeding at sleep time scale OT - infant feeding practices OT - socioeconomic status EDAT- 2026/05/04 12:34 MHDA- 2026/05/04 12:35 CRDT- 2026/05/04 10:11 PHST- 2026/01/01 00:00 [received] PHST- 2026/02/23 00:00 [accepted] PHST- 2026/05/04 12:35 [medline] PHST- 2026/05/04 12:34 [pubmed] PHST- 2026/05/04 10:11 [entrez] AID - 00005097-202603000-00005 [pii] AID - 10.4103/jisppd.jisppd_1_26 [doi] PST - ppublish SO - J Indian Soc Pedod Prev Dent. 2026 Mar 1;44(2):157-163. doi: 10.4103/jisppd.jisppd_1_26. Epub 2026 Apr 30. PMID- 42080151 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260504 LR - 20260813 IS - 2772-3682 (Electronic) IS - 2772-3682 (Linking) VI - 48 DP - 2026 May TI - Accuracy of a smartphone-based 3D imaging tool for height measurement and stunting detection among children 24-59 months of age in Nepal: a validation study. PG - 100774 LID - 10.1016/j.lansea.2026.100774 [doi] LID - 100774 AB - BACKGROUND: Detection of stunting in young children using traditional anthropometry has been a challenge at the community level especially in resource-constrained settings. We evaluated the performance of Child Growth Monitor (CGM), a smartphone-based 3D depth-imaging application, for screening of stunting, and height measurement among children (24-59 months of age) in Nepal. METHODS: At four health-posts in Rautahat district, Nepal, in October 2024, we conducted cross-sectional validation study comparing CGM's stunting detection against gold standard (manual measurement) and prospective reliability assessment with repeat measurements, four days apart. Eight trained enumerators collected data using calibrated height boards and CGM app. Validity was assessed through sensitivity, specificity and accuracy, reliability through intraclass correlation coefficients (ICC) and Technical Error of Measurement (TEM). Pitman's test evaluated variance. Bias was assessed using Bland Altman statistics. FINDINGS: 310 children were recruited, with analyses based on paired subsets (n = 261). Manual measurements identified 36% as stunted, while CGM detected 31.8%. CGM demonstrated 84.0% sensitivity, 98.2% specificity, 96.3% positive and 91.6% negative predictive values, and 93.1% accuracy. For height measurement, the ICC for intra-rater and inter-rater reliability were 0.990 (n = 76) and 0.992 (n = 75) respectively, with intra- and inter-rater TEM of 0.5 cm. Inter-method TEM was 0.7 cm. Pitman's test was significant; Bland-Altman showed mean bias of 0.3 cm. INTERPRETATION: CGM demonstrated accuracy and reliability for field-based stunting detection among children belonging to 24-59 months of age in Nepal. Future research on its use in younger children (6-24 months) and diverse settings will enable its integration into routine growth monitoring. FUNDING: This study was funded by the German Federal Foreign Office as part of the overall funding for the development of Child Growth Monitor app. CI - (c) 2026 The Author(s). FAU - Mukherjee, Ritika AU - Mukherjee R AD - Generating Research Insights for Development Council (GRID Council), H 54, Sector 63, Noida, Uttar Pradesh, 201309, India. FAU - Kaushik, Shivangi AU - Kaushik S AD - Welthungerhilfe, Deutsche Welthungerhilfe e.V. Friedrich-Ebert-Strasse 1, 53173, Bonn, Germany. FAU - Salah, Hamza AU - Salah H AD - Generating Research Insights for Development Council (GRID Council), H 54, Sector 63, Noida, Uttar Pradesh, 201309, India. FAU - Gupta, Ankit Kumar AU - Gupta AK AD - Child Growth Monitor, Welthungerhilfe, House No- 144, Shivam Footwear, Banda Road, Atarra, Banda, Uttar Pradesh, 210201, India. FAU - Sharma, Divita AU - Sharma D AD - Generating Research Insights for Development Council (GRID Council), H 54, Sector 63, Noida, Uttar Pradesh, 201309, India. FAU - Kahraman, Miriam AU - Kahraman M AD - Deutsche Welthungerhilfe e.V., Deutsche Welthungerhilfe e.V. Friedrich-Ebert-Strasse 1, 53173, Bonn, Germany. FAU - Vadyadagaya, Anupama AU - Vadyadagaya A AD - Child Growth Monitor, WHH, #12-513D1, Bantwal, Dakshina Kannada, Karnataka, 574219, India. FAU - Ali, Nasrullah AU - Ali N AD - Deutsche Welthungerhilfe e.V., Deutsche Welthungerhilfe e.V. Friedrich-Ebert-Strasse 1, 53173, Bonn, Germany. FAU - Rijal, Mahesh AU - Rijal M AD - Welthungerhilfe Nepal, 341, Kalika Mandir Marga, Sanepa, Lalitpur - 02, Nepal. FAU - Rai, Sampurna AU - Rai S AD - NTAG, Ukti Marg, Maitighar Height Kathmandu, Bagmati, 44600, Nepal. FAU - Mohapatra, Archisman AU - Mohapatra A AD - Generating Research Insights for Development Council (GRID Council), H 54, Sector 63, Noida, Uttar Pradesh, 201309, India. LA - eng PT - Journal Article DEP - 20260424 PL - England TA - Lancet Reg Health Southeast Asia JT - The Lancet regional health. Southeast Asia JID - 9918419282806676 PMC - PMC13129374 OTO - NOTNLM OT - Artificial intelligence OT - Child nutrition OT - Digital anthropometry OT - Growth monitoring OT - Health technology OT - Malnutrition OT - South-East Asia COIS- SK, AG, MK, NA, and SR were members of the CGM study team but were not involved in the formal data analysis for this manuscript. The authors declare no other competing interests. EDAT- 2026/05/04 12:34 MHDA- 2026/05/04 12:35 PMCR- 2026/04/24 CRDT- 2026/05/04 06:41 PHST- 2026/01/16 00:00 [received] PHST- 2026/04/02 00:00 [revised] PHST- 2026/04/09 00:00 [accepted] PHST- 2026/05/04 12:35 [medline] PHST- 2026/05/04 12:34 [pubmed] PHST- 2026/05/04 06:41 [entrez] PHST- 2026/04/24 00:00 [pmc-release] AID - S2772-3682(26)00059-4 [pii] AID - 100774 [pii] AID - 10.1016/j.lansea.2026.100774 [doi] PST - epublish SO - Lancet Reg Health Southeast Asia. 2026 Apr 24;48:100774. doi: 10.1016/j.lansea.2026.100774. eCollection 2026 May. PMID- 42077526 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260504 LR - 20260813 IS - 0300-0508 (Print) IS - 1708-8313 (Electronic) IS - 0300-0508 (Linking) VI - 77 IP - 4 DP - 2025 Nov TI - Exploration of Potential Determinants of Implementation of a Clinical Practice Guide to Enhance Physical Activity Participation of Children With Developmental Coordination Disorder. PG - 490-499 LID - 10.3138/ptc-2023-0071 [doi] AB - Purpose: This project explored the potential determinants (barriers and facilitators) of implementing a recently developed clinical practice guide (CPG) for the promotion and enhancement of the physical activity participation of children with developmental coordination disorder (DCD) prior to its release for clinical use. Method: The validated Clinician Guideline Determinants Questionnaire was used to explore the potential determinants reported by nine physiotherapists who provide services to children with DCD. Results: There was 100% agreement with the CPG content. All participants also agreed that following the CPG recommendations would improve care delivery and patient outcomes. Potential barriers of implementation were related to several factors, such as guideline factors (e.g., a lot of information, need for a visual summary), individual health professional factors (e.g., need for CPG training and experience), professional interactions (e.g., need to create community and school partnerships), and incentives and resources (e.g., need for dedicated time). Facilitators were having the above-mentioned needs met. Conclusions: Successful implementation of this CPG by paediatric physiotherapists may require: (1) that certain CPG and educational resources be put in place; (2) support to develop community and school partnerships, and (3) support from managers. CI - (c) Canadian Physiotherapy Association, 2025. FAU - Demers, Isabelle AU - Demers I AD - From the: Centre for Interdisciplinary Research in Rehabilitation and Social Integration (CIRRIS), CIUSSS de la Capitale Nationale, Quebec, Quebec, Canada. AD - Faculty of Medicine, Universite Laval, Quebec, Quebec, Canada. FAU - Lamontagne, Marie-Eve AU - Lamontagne ME AD - From the: Centre for Interdisciplinary Research in Rehabilitation and Social Integration (CIRRIS), CIUSSS de la Capitale Nationale, Quebec, Quebec, Canada. AD - Faculty of Medicine, Universite Laval, Quebec, Quebec, Canada. FAU - Moffet, Helene AU - Moffet H AD - From the: Centre for Interdisciplinary Research in Rehabilitation and Social Integration (CIRRIS), CIUSSS de la Capitale Nationale, Quebec, Quebec, Canada. AD - Faculty of Medicine, Universite Laval, Quebec, Quebec, Canada. FAU - Maltais, Desiree B AU - Maltais DB AD - From the: Centre for Interdisciplinary Research in Rehabilitation and Social Integration (CIRRIS), CIUSSS de la Capitale Nationale, Quebec, Quebec, Canada. AD - Faculty of Medicine, Universite Laval, Quebec, Quebec, Canada. LA - eng PT - Journal Article DEP - 20240603 PL - Canada TA - Physiother Can JT - Physiotherapy Canada. Physiotherapie Canada JID - 0346574 PMC - PMC13134831 OTO - NOTNLM OT - child OT - exercise OT - guideline OT - knowledge translation OT - motor skills disorders. COIS- The authors have nothing to disclose. EDAT- 2026/05/04 12:34 MHDA- 2026/05/04 12:35 PMCR- 2025/06/03 CRDT- 2026/05/04 06:17 PHST- 2023/08/31 00:00 [received] PHST- 2024/03/09 00:00 [revised] PHST- 2024/03/11 00:00 [accepted] PHST- 2026/05/04 12:35 [medline] PHST- 2026/05/04 12:34 [pubmed] PHST- 2026/05/04 06:17 [entrez] PHST- 2025/06/03 00:00 [pmc-release] AID - 10.3138/ptc-2023-0071 [doi] PST - ppublish SO - Physiother Can. 2025 Nov;77(4):490-499. doi: 10.3138/ptc-2023-0071. Epub 2024 Jun 3. PMID- 42077456 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - The impact of daily steps on polycystic ovary syndrome patients. PG - 1744228 LID - 10.3389/fendo.2026.1744228 [doi] LID - 1744228 AB - OBJECTIVES: As a reproductive-metabolic disorder, lifestyle interventions play a crucial role in managing Polycystic Ovary Syndrome (PCOS) patients. However, maintaining physical activity in PCOS patients is often challenging. Daily steps are now widely used to provide relatively simple physical activity goals for the general public. This study examines the impact of daily steps on patients with PCOS, aiming to develop simple and effective intervention strategies for them. METHODS: This study included anthropometric parameters, metabolic indicators, sex hormones, and daily steps from women aged 16-40 years with PCOS (n=167) and without PCOS (n=152). Participants were divided into obese and non-obese groups based on BMI >/= 25 kg/m(2) for intergroup comparisons, comprehensively evaluating the association between daily steps and various indicators. RESULTS: Among PCOS patients, 42.9% were sedentary, while only 8.8% were active or highly active. Indicators significantly correlated with step count in the correlation analysis underwent further multivariate linear regression analysis. RCS analysis further validated the positive linear relationship between HDL and daily step count in PCOS patients (P for non-linear = 0.125). For PCOS patients without obesity, daily step count showed linear relationships with TG (P for non-linear = 0.211), HDL (P for non-linear = 0.255), and VAI (P for non-linear = 0.839). Additionally, daily steps showed linear relationships with body fat percentage (BFP, p=0.033, R (2) = 0.454), android fat percentage (p=0.045, R (2) = 0.413), Android/Gynoid ratio (A/G, p=0.041, R (2) = 0.425), fat mass index (FMI, p=0.007, R (2) = 0.671), and percent trunk fat (PTF, p=0.041, R (2) = 0.427). CONCLUSION: Daily steps exhibits a beneficial association with lipid and body fat metabolism in PCOS patients without obesity, making it a viable indicator for quantifying physical activity that can be incorporated into PCOS patient management. CI - Copyright (c) 2026 Wang, Zhang, Ma, Luo and Li. FAU - Wang, Tianmei AU - Wang T AD - Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Zhang, LiJuan AU - Zhang L AD - Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Ma, Liya AU - Ma L AD - Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Luo, Xiaodong AU - Luo X AD - Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Li, Cong AU - Li C AD - Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. LA - eng PT - Journal Article DEP - 20260416 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - Female MH - *Polycystic Ovary Syndrome/physiopathology/metabolism/therapy MH - Adolescent MH - Young Adult MH - Adult MH - *Obesity/complications/physiopathology MH - *Exercise/physiology MH - Body Mass Index MH - *Walking/physiology PMC - PMC13128351 OTO - NOTNLM OT - PCOS OT - abdominal fat OT - daily steps OT - metabolism OT - walking COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/04 12:33 MHDA- 2026/05/04 12:34 PMCR- 2026/04/16 CRDT- 2026/05/04 06:16 PHST- 2025/11/11 00:00 [received] PHST- 2026/03/20 00:00 [revised] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/05/04 12:34 [medline] PHST- 2026/05/04 12:33 [pubmed] PHST- 2026/05/04 06:16 [entrez] PHST- 2026/04/16 00:00 [pmc-release] AID - 10.3389/fendo.2026.1744228 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Apr 16;17:1744228. doi: 10.3389/fendo.2026.1744228. eCollection 2026. PMID- 42077453 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260818 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Development and validation of age- and gender-specific reference intervals for the triglyceride-glucose index in a large Chinese healthy adult population. PG - 1793587 LID - 10.3389/fendo.2026.1793587 [doi] LID - 1793587 AB - BACKGROUND: The triglyceride-glucose (TyG) index is a recognized surrogate marker of insulin resistance. However, validated reference intervals (RIs) for the TyG index in large, general healthy populations are currently lacking, limiting its standardized application in clinical practice. METHODS: This retrospective study established and validated TyG index RIs using data from adults (>/=18 years) undergoing routine health examinations. The derivation cohort included individuals without known diabetes, dyslipidemia, or obesity. The TyG index was calculated as ln[fasting triglyceride (mg/dL) x fasting blood glucose (mg/dL)/2]. After outlier exclusion, we analyzed the age-TyG relationship using restricted cubic splines and threshold analysis to determine optimal age stratification. Gender- and age-specific RIs were defined as the 2.5th-97.5th percentiles. An independent cohort of 127,143 healthy individuals was used for validation, with success defined as <10% of values falling outside the proposed RIs. RESULTS: A total of 201,623 individuals were initially screened for the derivation cohort. Analysis revealed a significant nonlinear relationship between TyG and age, with an inflection point at 64.21 years, justifying stratification into 18-64 and >/=64-year groups. The overall RI was 7.47-8.90. Stratified RIs were: 7.47-8.91 for males aged 18-64, 7.46-8.90 for females aged 18-64, 7.44-8.90 for males aged >/=64, and 7.50-8.90 for females aged >/=64. In the independent validation cohort, only 4.76% to 5.37% of values fell outside the corresponding RIs, confirming their robustness. CONCLUSION: This study establishes and validates age- and gender-stratified reference intervals for the TyG index in a large Chinese healthy population. These intervals, benchmarked against a critical age threshold of 64 years, provide a reliable standard for clinical interpretation and enhance the utility of the TyG index in metabolic risk assessment. CI - Copyright (c) 2026 Huang, Qin, Lu, Li, Wang, He, Mai, Lu, Lu, Huang, Zheng, Zhang and Feng. FAU - Huang, Shanshan AU - Huang S AD - Department of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. FAU - Qin, Liming AU - Qin L AD - Department of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. FAU - Lu, Chuanfu AU - Lu C AD - Department of General Internal Medicine, Shibu Health Center, Nanning, Guangxi, China. FAU - Li, Weinan AU - Li W AD - Department of General Internal Medicine, Shibu Health Center, Nanning, Guangxi, China. FAU - Wang, Yibo AU - Wang Y AD - Department of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. FAU - He, Dan AU - He D AD - Department of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. FAU - Mai, Yuni AU - Mai Y AD - Department of General Internal Medicine, Shibu Health Center, Nanning, Guangxi, China. FAU - Lu, Na AU - Lu N AD - Department of General Internal Medicine, Shibu Health Center, Nanning, Guangxi, China. FAU - Lu, Qiuyu AU - Lu Q AD - Department of General Internal Medicine, Shibu Health Center, Nanning, Guangxi, China. FAU - Huang, Shiwei AU - Huang S AD - Department of General Internal Medicine, Shibu Health Center, Nanning, Guangxi, China. FAU - Zheng, Xiaowen AU - Zheng X AD - Department of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. FAU - Zhang, Jianfeng AU - Zhang J AD - Department of Emergency Medicine, Wuming Hospital of Guangxi Medical University, Nanning, Guangxi, China. FAU - Feng, Jihua AU - Feng J AD - Department of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260416 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Biomarkers) RN - 0 (Blood Glucose) RN - 0 (Triglycerides) RN - Chinese people SB - IM MH - Adolescent MH - Adult MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - Age Factors MH - Biomarkers/blood MH - *Blood Glucose/analysis/metabolism MH - China/epidemiology MH - Insulin Resistance MH - Reference Values MH - Retrospective Studies MH - Sex Factors MH - *Triglycerides/blood MH - East Asian People PMC - PMC13128429 OTO - NOTNLM OT - Chinese population OT - age OT - gender OT - reference intervals OT - triglyceride-glucose index COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/04 12:34 MHDA- 2026/05/04 12:35 PMCR- 2026/04/16 CRDT- 2026/05/04 06:16 PHST- 2026/01/22 00:00 [received] PHST- 2026/03/25 00:00 [revised] PHST- 2026/03/27 00:00 [accepted] PHST- 2026/05/04 12:35 [medline] PHST- 2026/05/04 12:34 [pubmed] PHST- 2026/05/04 06:16 [entrez] PHST- 2026/04/16 00:00 [pmc-release] AID - 10.3389/fendo.2026.1793587 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Apr 16;17:1793587. doi: 10.3389/fendo.2026.1793587. eCollection 2026. PMID- 42075650 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 1648-9144 (Electronic) IS - 1010-660X (Print) IS - 1010-660X (Linking) VI - 62 IP - 4 DP - 2026 Apr 17 TI - The Relationship Between Body Posture and Psychophysical Functioning in Children with Obesity: A Narrative Literature Review and Future Research Perspective Related to Preliminary Research Concept. LID - 10.3390/medicina62040779 [doi] LID - 779 AB - Childhood obesity is a growing global health problem with significant biomechanical and psychosocial consequences. While many studies have examined these domains separately, few integrate postural abnormalities, psychophysical functioning, and lifestyle factors within a single framework. This narrative review synthesises the literature published between 2005 and 2025 to summarise current evidence and identify research gaps. The findings indicate that overweight and obesity increase the risk of musculoskeletal deviations such as genu valgum, flat feet, and increased lumbar lordosis, as well as altered gait biomechanics and reduced motor competence. Excess body weight is also associated with lower self-esteem, negative body image, depressive symptoms, and reduced health-related quality of life in children and adolescents. These outcomes appear to be influenced by modifiable lifestyle factors, including parental health behaviours, sleep patterns, and screen time, although reported associations remain inconsistent. Notably, few studies address biomechanical, psychological, and environmental factors simultaneously, which limits the understanding of their interactions. To address this gap, a prospective observational study of 250-300 children aged 7-17 years is proposed. The study will combine objective postural assessments, validated psychometric tools, and lifestyle analyses at baseline and after a 12-14-month follow-up. This integrated approach aims to identify postural compensation patterns, psychosocial risk trajectories, and modifiable behavioural predictors associated with childhood obesity, supporting the development of early preventive and interdisciplinary interventions. FAU - Korzan, Kornelia AU - Korzan K AUID- ORCID: 0009-0000-8663-145X AD - Department of Physiotherapy, Faculty of Health Sciences in Katowice, Medical University of Silesia, 40-055 Katowice, Poland. AD - Doctoral School, Medical University of Silesia, 40-055 Katowice, Poland. FAU - Czepczor-Bernat, Kamila AU - Czepczor-Bernat K AUID- ORCID: 0000-0002-1707-0000 AD - Department of Pediatrics, Pediatric Obesity and Metabolic Bone Diseases, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-055 Katowice, Poland. FAU - Matusik, Pawel AU - Matusik P AD - Department of Pediatrics, Pediatric Obesity and Metabolic Bone Diseases, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-055 Katowice, Poland. FAU - Brzek, Anna AU - Brzek A AUID- ORCID: 0000-0002-2321-2888 AD - Department of Physiotherapy, Faculty of Health Sciences in Katowice, Medical University of Silesia, 40-055 Katowice, Poland. LA - eng GR - UDA-FESL. 10.25-12.01.05/FB/23-00; BNW-NWD/894/2024/FE SL project entitled "Supporting the region's transformation by strengthening the capacity of the Doctoral School of the Medical University of Silesia in Katowice"/ PT - Journal Article PT - Review DEP - 20260417 PL - Switzerland TA - Medicina (Kaunas) JT - Medicina (Kaunas, Lithuania) JID - 9425208 SB - IM MH - Humans MH - Child MH - *Posture/physiology MH - Adolescent MH - *Pediatric Obesity/psychology/complications/physiopathology MH - Female MH - Male MH - Quality of Life/psychology MH - *Psychophysics/methods PMC - PMC13118225 OTO - NOTNLM OT - body posture OT - childhood obesity OT - psychophysical functioning COIS- The authors declare no conflict of interest. EDAT- 2026/05/04 06:32 MHDA- 2026/05/04 06:33 PMCR- 2026/04/17 CRDT- 2026/05/04 01:19 PHST- 2026/03/02 00:00 [received] PHST- 2026/03/30 00:00 [revised] PHST- 2026/04/14 00:00 [accepted] PHST- 2026/05/04 06:33 [medline] PHST- 2026/05/04 06:32 [pubmed] PHST- 2026/05/04 01:19 [entrez] PHST- 2026/04/17 00:00 [pmc-release] AID - medicina62040779 [pii] AID - medicina-62-00779 [pii] AID - 10.3390/medicina62040779 [doi] PST - epublish SO - Medicina (Kaunas). 2026 Apr 17;62(4):779. doi: 10.3390/medicina62040779. PMID- 42075578 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 1648-9144 (Electronic) IS - 1010-660X (Print) IS - 1010-660X (Linking) VI - 62 IP - 4 DP - 2026 Apr 7 TI - Age-Dependent Risk Factors in Pediatric Sleep-Disordered Breathing: A Large-Scale Cross-Sectional Study. LID - 10.3390/medicina62040707 [doi] LID - 707 AB - Background and Objectives: Sleep-related breathing disorders (SRBDs) are common but often underdiagnosed in children. Early identification is essential, as untreated pediatric SRBDs can lead to cognitive, metabolic, and cardiovascular complications. This study aimed to estimate the prevalence of children at risk for SRBDs, defined as those screening positive based on Pediatric Sleep Questionnaire (PSQ) scores, and to analyze the association with potential risk factors in the general pediatric population of Lithuania. Materials and Methods: This cross-sectional study included 1929 children aged 2-17 years. Parents completed a questionnaire covering demographics, health status, and the PSQ. A validated Lithuanian version of the PSQ was used, with >/=8 (40%) positive responses indicating suspected SRBDs. Results: Overall, 14.9% of children were suspected of having SRBDs, with the highest prevalence among those aged 7-11 years (17.5%), followed by 2-6 years (14.9%) and >/=12 years (12.6%) (p = 0.032). In preschoolers (2-6 years), the strongest predictors were attention deficit hyperactivity disorder (ADHD; p < 0.001, OR 4.456, 95% CI 1.992-9.968) and allergic rhinitis (p < 0.001, OR 2.268, 95% CI 1.433-3.591). In children aged 7-11 years, endocrine diseases showed the strongest association (p < 0.001, OR 13.366, 95% CI 2.914-61.313), followed by ADHD (p = 0.001, OR 5.693, 95% CI 1.981-16.363) and adenotonsillar hypertrophy (p < 0.001, OR 3.079, 95% CI 1.839-5.156). In adolescents (>/=12 years), SRBDs were primarily associated with ADHD (p < 0.001, OR 17.513, 95% CI 9.597-31.961) and endocrine diseases (p < 0.001, OR 6.214, 95% CI 2.965-13.020), while obesity remained significant (p < 0.001, OR 3.400, 95% CI 2.106-5.489). Conclusions: Approximately 15% of Lithuanian children were at risk for SRBDs. Risk factors differed by age: adenotonsillar hypertrophy in school-aged children, allergic rhinitis in preschoolers, and obesity in adolescents, whereas ADHD was associated across age groups. FAU - Oboleviciene, Gintare AU - Oboleviciene G AUID- ORCID: 0000-0001-7579-0789 AD - Pediatric Department, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50103 Kaunas, Lithuania. FAU - Mejeryte, Viktorija AU - Mejeryte V AD - Pediatric Department, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50103 Kaunas, Lithuania. FAU - Jotautaite, Norvile AU - Jotautaite N AD - Pediatric Department, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50103 Kaunas, Lithuania. FAU - Rinkeviciene, Egle AU - Rinkeviciene E AD - Pediatric Department, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50103 Kaunas, Lithuania. FAU - Katiniene, Inga AU - Katiniene I AD - Pediatric Department, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50103 Kaunas, Lithuania. FAU - Gurskis, Vaidotas AU - Gurskis V AD - Pediatric Department, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50103 Kaunas, Lithuania. FAU - Kevalas, Rimantas AU - Kevalas R AD - Pediatric Department, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50103 Kaunas, Lithuania. FAU - Miseviciene, Valdone AU - Miseviciene V AUID- ORCID: 0000-0003-4753-8011 AD - Pediatric Department, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50103 Kaunas, Lithuania. LA - eng PT - Journal Article DEP - 20260407 PL - Switzerland TA - Medicina (Kaunas) JT - Medicina (Kaunas, Lithuania) JID - 9425208 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Child MH - Child, Preschool MH - Lithuania/epidemiology MH - Risk Factors MH - Female MH - Male MH - *Sleep Apnea Syndromes/epidemiology/etiology MH - Adolescent MH - Surveys and Questionnaires MH - Prevalence MH - Age Factors MH - Attention Deficit Disorder with Hyperactivity/complications/epidemiology PMC - PMC13117163 OTO - NOTNLM OT - Pediatric Sleep Questionnaire OT - pediatric sleep apnea OT - prevalence of SRBDs OT - risk factors in children OT - sleep-related breathing disorders COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:33 MHDA- 2026/05/04 06:34 PMCR- 2026/04/07 CRDT- 2026/05/04 01:18 PHST- 2026/03/03 00:00 [received] PHST- 2026/03/22 00:00 [revised] PHST- 2026/04/03 00:00 [accepted] PHST- 2026/05/04 06:34 [medline] PHST- 2026/05/04 06:33 [pubmed] PHST- 2026/05/04 01:18 [entrez] PHST- 2026/04/07 00:00 [pmc-release] AID - medicina62040707 [pii] AID - medicina-62-00707 [pii] AID - 10.3390/medicina62040707 [doi] PST - epublish SO - Medicina (Kaunas). 2026 Apr 7;62(4):707. doi: 10.3390/medicina62040707. PMID- 42075098 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260926 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 8 DP - 2026 Apr 18 TI - Social Inequalities in T2DM-Related Risk Patterns and Diabetes-Related Knowledge Among Hungarian Secondary School Students Aged 16-20 Years: A Cross-Sectional Study Using an Adapted FINDRISC-Based Screening Framework. LID - 10.3390/nu18081286 [doi] LID - 1286 AB - BACKGROUND/OBJECTIVES: Type 2 diabetes mellitus (T2DM) is a major public health challenge, and several lifestyle-related factors associated with later T2DM may already emerge during the secondary school years. Socioeconomic status (SES), nutrition-related behaviors, physical activity, and basic diabetes-related knowledge may shape these early risk-related patterns. This study examined the relationships between SES, adapted FINDRISC-based T2DM-related risk patterns, and diabetes-related knowledge among Hungarian secondary school students aged 16-20 years. METHODS: A nationwide, cross-sectional questionnaire survey was conducted among students attending Hungarian Baptist secondary schools (N = 1585). SES was classified by Two-Step cluster analysis based on parental education, parental occupation, number of books in the household, and frequency of travel abroad. Relative T2DM-related risk patterns were described using an age-adapted FINDRISC-based screening approach, and basic diabetes-related knowledge was assessed using a 12-item questionnaire. Associations were examined using cross-tabulation and regression analyses in SPSS version 27.0. RESULTS: Most respondents fell into the lower categories of the adapted FINDRISC-based screening framework, whereas 7.4% were classified into the moderate or high adapted FINDRISC-based screening categories. SES was significantly associated with adapted FINDRISC-based screening categories (p < 0.001). Compared with the medium-SES group, students in the low-SES group had higher odds of belonging to a higher adapted FINDRISC-based screening category (OR = 1.81; 95% CI: 1.27-2.57; p = 0.001). SES was also significantly associated with basic diabetes-related knowledge profiles (p = 0.015); students with high SES were less likely to be in the low-knowledge group than in the high-knowledge group (OR = 0.62; p = 0.039). CONCLUSIONS: Social inequalities in T2DM-related risk patterns and diabetes-related knowledge are already visible among secondary school students aged 16-20 years. The adapted FINDRISC-based approach may be useful as a school-based, non-invasive descriptive screening framework for characterizing relative T2DM-related risk patterns, but it is not a validated risk prediction instrument for this age group. FAU - Fuzesi, Brigitta AU - Fuzesi B AD - Faculty of Health Sciences, Doctoral School, Semmelweis University, 1085 Budapest, Hungary. AD - National Federation of Diabetes Associations, 1116 Budapest, Hungary. FAU - Porzse, Gabor Ferenc AU - Porzse GF AD - Department of Social Sciences, Faculty of Health Sciences, Semmelweis University, 1085 Budapest, Hungary. FAU - Bornemissza, Krisztina Antonia AU - Bornemissza KA AD - Institute of Sociology, Faculty of Humanities and Social Sciences, Pazmany Peter Catholic University, 1088 Budapest, Hungary. FAU - Horkai, Anita AU - Horkai A AD - Department of Social Sciences, Faculty of Health Sciences, Semmelweis University, 1085 Budapest, Hungary. FAU - Sallai, Judit AU - Sallai J AD - Central Department of Anaesthesiology and Intensive Care, North Pest Central Hospital-Honved Hospital, 1134 Budapest, Hungary. FAU - Feith, Helga Judit AU - Feith HJ AUID- ORCID: 0000-0001-8855-5059 AD - Department of Social Sciences, Faculty of Health Sciences, Semmelweis University, 1085 Budapest, Hungary. LA - eng GR - 2023-2.1.2-KDP-2023-00016/Ministry of Culture and Innovation of Hungary from the National Research, Development and Innovation Fund/ PT - Journal Article DEP - 20260418 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - Cross-Sectional Studies MH - Male MH - Female MH - *Diabetes Mellitus, Type 2/epidemiology/diagnosis MH - *Health Knowledge, Attitudes, Practice MH - Young Adult MH - Hungary/epidemiology MH - Risk Factors MH - Surveys and Questionnaires MH - *Students/statistics & numerical data/psychology MH - Socioeconomic Disparities in Health MH - Schools MH - Mass Screening/methods MH - Socioeconomic Factors MH - Social Class PMC - PMC13119404 OTO - NOTNLM OT - FINDRISC OT - diabetes-related knowledge OT - health behavior OT - secondary school students OT - socioeconomic status OT - type 2 diabetes OT - young people COIS- The authors declare that they have no conflicts of interest. EDAT- 2026/05/04 06:32 MHDA- 2026/05/04 06:33 PMCR- 2026/04/18 CRDT- 2026/05/04 01:17 PHST- 2026/02/14 00:00 [received] PHST- 2026/04/13 00:00 [revised] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/05/04 06:33 [medline] PHST- 2026/05/04 06:32 [pubmed] PHST- 2026/05/04 01:17 [entrez] PHST- 2026/04/18 00:00 [pmc-release] AID - nu18081286 [pii] AID - nutrients-18-01286 [pii] AID - 10.3390/nu18081286 [doi] PST - epublish SO - Nutrients. 2026 Apr 18;18(8):1286. doi: 10.3390/nu18081286. PMID- 42075096 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 8 DP - 2026 Apr 18 TI - Children's Eating Behaviour Questionnaire Dimensions and Central Adiposity in Spanish Schoolchildren: Age-Stratified Associations. LID - 10.3390/nu18081283 [doi] LID - 1283 AB - Background/Objectives: Elevated central adiposity (ECA) in childhood is associated with early cardiometabolic risk and hemodynamic alterations. However, evidence in Spanish schoolchildren regarding the relationship between eating behavior traits and central adiposity is limited, particularly across developmental stages. This study aimed to examine the association between Children's Eating Behaviour Questionnaire (CEBQ) subscales and ECA, and to explore potential differences by age group. Methods: A cross-sectional study was conducted in 496 rural schoolchildren aged 6-15 years. ECA was defined using the waist-to-height ratio (WHtR) and sex-specific cut-offs validated for the Spanish pediatric population. Eating behavior was assessed with the CEBQ (Z-scores), and diet quality was measured using the KIDMED index. Multivariable logistic regression models were adjusted for sex, KIDMED score, and maternal education. Analyses were subsequently stratified by age (6-9 and 10-15 years). Results: The prevalence of ECA was 45.90%. In fully adjusted models, higher Food Responsiveness (FR) was associated with increased odds of ECA, while Satiety Responsiveness (SR) acted as a protective factor; sex also showed an independent association. After stratification, sex remained the only significant predictor in children aged 6-9 years. Among those aged 10-15 years, FR was significantly associated with ECA (p = 0.008), while Slowness in Eating (SE) showed a borderline positive association in the adjusted model (p = 0.049) and was therefore interpreted cautiously. SR and Emotional Undereating (EU) showed protective trends near significance (p = 0.081 and p = 0.082, respectively). Conclusions: The association between eating behavior traits and ECA varies by age. In older children, FR showed a robust association with ECA, whereas no behavioral predictors were observed in younger children. The protective role of SR in the global model and the emergence of behavioral predictors in older participants highlight the importance of targeted interventions during late childhood. FAU - Recio-Anon, Carlos AU - Recio-Anon C AUID- ORCID: 0009-0003-6511-6725 AD - Critical Care and Emergency Services Unit, Distrito Sanitario Cordoba Guadalquivir, 14011 Cordoba, Spain. AD - EPINUT Research Group (Ref. 929325), Complutense University of Madrid, 28037 Madrid, Spain. FAU - Lendinez-Jurado, Alfonso AU - Lendinez-Jurado A AUID- ORCID: 0000-0003-4408-1335 AD - UGC Churriana, Distrito Sanitario Malaga-Guadalhorce, 29009 Malaga, Spain. AD - Pediatric Gastroenterology Unit, Vithas Xanit International Hospital, 29630 Malaga, Spain. AD - Instituto de Investigacion Biomedica de Malaga (IBIMA)-Plataforma BIONAND, 29010 Malaga, Spain. FAU - Mata-Ordonez, Fernando AU - Mata-Ordonez F AUID- ORCID: 0000-0003-4126-577X AD - Department of Pharmacy and Nutrition, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, 28670 Madrid, Spain. AD - Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), Hospital Universitario Reina Sofia, 14004 Cordoba, Spain. FAU - Carracedo-Anon, Julia AU - Carracedo-Anon J AUID- ORCID: 0000-0002-8422-812X AD - Department of Genetics, Physiology and Microbiology, Faculty of Biological Sciences, Complutense University of Madrid, Health Research Institute Hospital 12 de Octubre (Imas12), 28041 Madrid, Spain. FAU - Gonzalez-Martin, Antonio AU - Gonzalez-Martin A AUID- ORCID: 0000-0003-0276-0778 AD - Department of Biodiversity, Ecology and Evolution, Faculty of Biological Sciences, Complutense University of Madrid, 28040 Madrid, Spain. FAU - Marrodan-Serrano, Maria Dolores AU - Marrodan-Serrano MD AUID- ORCID: 0000-0002-1697-1923 AD - EPINUT Research Group (Ref. 929325), Complutense University of Madrid, 28037 Madrid, Spain. AD - Department of Biodiversity, Ecology and Evolution, Faculty of Biological Sciences, Complutense University of Madrid, 28040 Madrid, Spain. LA - eng PT - Journal Article DEP - 20260418 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - Spain/epidemiology MH - Adolescent MH - *Feeding Behavior MH - Cross-Sectional Studies MH - *Obesity, Abdominal/epidemiology MH - Surveys and Questionnaires MH - *Child Behavior MH - Age Factors MH - Adiposity MH - *Pediatric Obesity/epidemiology MH - Emotional Eating MH - Prevalence PMC - PMC13118514 OTO - NOTNLM OT - KIDMED OT - central adiposity OT - children's eating behaviour questionnaire OT - eating behavior OT - pediatrics OT - schoolchildren OT - waist-to-height ratio COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:33 MHDA- 2026/05/04 06:34 PMCR- 2026/04/18 CRDT- 2026/05/04 01:17 PHST- 2026/03/10 00:00 [received] PHST- 2026/04/10 00:00 [revised] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/05/04 06:34 [medline] PHST- 2026/05/04 06:33 [pubmed] PHST- 2026/05/04 01:17 [entrez] PHST- 2026/04/18 00:00 [pmc-release] AID - nu18081283 [pii] AID - nutrients-18-01283 [pii] AID - 10.3390/nu18081283 [doi] PST - epublish SO - Nutrients. 2026 Apr 18;18(8):1283. doi: 10.3390/nu18081283. PMID- 42075045 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260818 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 8 DP - 2026 Apr 14 TI - Sex Differences in the Associations of Physical Activity and Planetary Health Diet with Obesity and Depressive Symptoms Among Adolescents in Zhejiang Province: An Observational Study. LID - 10.3390/nu18081232 [doi] LID - 1232 AB - Background: Adolescent obesity and depressive symptoms have increased concurrently, often presenting as co-occurrence. However, evidence on the timing of physical activity (e.g., weekday vs. weekend) and adherence to planetary health diets remains limited. This study examined these associations among adolescents in Zhejiang Province from 2022 to 2024. Methods: A total of 261,495 adolescents aged 11-18 years were included. Physical activity (PA) and dietary behaviors were assessed through the China Common Disease and Risk Factor Surveillance among Students questionnaire (reliability: Cronbach's alpha = 0.84, validity: RMSEA = 0.07). The plant-based Planetary Health Diet Index (PHDI-green) adherence was defined as consuming at least one daily serving of both vegetables and fruits. Depressive symptoms were measured using the Center for Epidemiologic Studies Depression (CES-D) scale, and co-occurrence was defined as the coexistence of obesity and depressive symptoms. Temporal trends were tested using chi(2) tests. Sex-stratified logistic regression, restricted cubic spline analyses, and population attributable fraction (PAF) analyses were applied. Results: From 2022 to 2024, obesity (p for trend = 0.013) and depressive symptoms (p for trend = 0.003) increased significantly, while co-occurrence remained stable (p for trend = 0.058). Boys had higher obesity and co-occurrence, whereas girls showed higher depressive symptoms (all p < 0.001). Higher weekly PA, greater weekend PA and PHDI-green adherence were associated with reduced odds of obesity in both sexes (all p < 0.001). Weekend PA showed stronger associations with depressive symptoms among girls, while PHDI-green showed stronger inverse associations in boys (p for sex difference < 0.001). PAF analyses suggested that low weekend PA accounted for substantial proportions of cases (girls: obesity 10.17%, depressive symptoms 31.30%, co-occurrence 35.64%). Joint adherence to adequate PA and PHDI-green conferred the lowest odds of co-occurrence (boys: OR = 0.40, 95% CI: 0.34-0.46; girls: OR = 0.33, 95% CI: 0.26-0.43). Conclusions: Adherence to the Planetary Health Diet may be particularly relevant for boys, whereas PA-especially weekend PA-may be more strongly associated with health outcomes among girls. These findings suggest the importance of sex-specific and time-targeted behavioral strategies for obesity, depressive symptoms, and their co-occurrence in adolescents. FAU - Lu, Qu AU - Lu Q AUID- ORCID: 0000-0001-8681-9233 AD - School of Health Policy and Management, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. FAU - Chen, Manman AU - Chen M AD - School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. FAU - Wang, Jiahui AU - Wang J AD - School of Health Policy and Management, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. FAU - Zhao, Yuankai AU - Zhao Y AUID- ORCID: 0009-0002-9102-857X AD - School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. FAU - Ye, Zichen AU - Ye Z AUID- ORCID: 0000-0003-0585-6687 AD - School of Health Policy and Management, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. FAU - Hu, Jie AU - Hu J AUID- ORCID: 0000-0003-2940-6525 AD - School of Pharmacy and Medical Sciences, Griffith University, Nathan, Brisbane, QLD 4111, Australia. AD - Faculty of Medicine, The University of Queensland, St Lucia, Brisbane, QLD 4072, Australia. FAU - Meng, Jia AU - Meng J AD - Division of School Health, Department of Nutrition and Food Safety, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China. FAU - Li, Juanjuan AU - Li J AD - Division of School Health, Department of Nutrition and Food Safety, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China. FAU - Shen, Yu AU - Shen Y AUID- ORCID: 0000-0002-5984-8781 AD - Division of School Health, Department of Nutrition and Food Safety, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China. FAU - Gu, Fang AU - Gu F AUID- ORCID: 0000-0001-9163-0566 AD - Division of School Health, Department of Nutrition and Food Safety, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China. FAU - Jiang, Yu AU - Jiang Y AD - School of Health Policy and Management, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. FAU - Dong, Bin AU - Dong B AUID- ORCID: 0000-0002-8123-4401 AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100871, China. LA - eng GR - 25&ZD252/the Major Projects of the National Social Science Fund of China/ GR - 7242187/the Beijing Natural Science Foundation/ GR - Grant No. 2023ZD0508500, 2023ZD0508505/the Chinese National Science and Technology Innovation 2030, Noncommunicable Chronic Dis-eases-National Science and Technology Major Project/ GR - 825B2103/the National Natural Science Foundation of China/ GR - 201920102401/the Research on the Construction of a New Public Health Science System and Talent Training Model/ PT - Journal Article PT - Observational Study DEP - 20260414 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Adolescent MH - China/epidemiology MH - *Depression/epidemiology MH - Male MH - *Exercise MH - *Pediatric Obesity/epidemiology MH - Child MH - *Diet, Healthy/statistics & numerical data MH - Sex Factors PMC - PMC13118374 OTO - NOTNLM OT - adolescent OT - co-occurrence OT - physical activity OT - planetary health diet COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:33 MHDA- 2026/05/04 06:34 PMCR- 2026/04/14 CRDT- 2026/05/04 01:16 PHST- 2026/03/03 00:00 [received] PHST- 2026/04/11 00:00 [revised] PHST- 2026/04/13 00:00 [accepted] PHST- 2026/05/04 06:34 [medline] PHST- 2026/05/04 06:33 [pubmed] PHST- 2026/05/04 01:16 [entrez] PHST- 2026/04/14 00:00 [pmc-release] AID - nu18081232 [pii] AID - nutrients-18-01232 [pii] AID - 10.3390/nu18081232 [doi] PST - epublish SO - Nutrients. 2026 Apr 14;18(8):1232. doi: 10.3390/nu18081232. PMID- 42075027 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 8 DP - 2026 Apr 11 TI - Chrononutrition, Body Composition, and Resting Metabolic Rate Among College Students: A Cross-Sectional Study. LID - 10.3390/nu18081214 [doi] LID - 1214 AB - BACKGROUND: Chrononutrition is essential for metabolic health, but relevant evidence in Chinese sports-majoring college students is still insufficient. This study aimed to identify chrononutrition patterns and their associations with body composition and resting metabolic rate (RMR) in college students from a sports university. METHODS: A cross-sectional study was conducted among 174 college students from Beijing Sport University (131 sports-majoring and 43 non-sports-majoring). Chrononutrition was measured by the validated Chinese version of the Chrononutrition Profile Questionnaire (CP-Q), body composition by dual-energy X-ray absorptiometry, and RMR by indirect calorimetry. Sample sizes varied across analyses according to data availability, and 133 participants provided valid data for both body composition and resting metabolic rate (RMR) assessments. RESULTS: Frequent night eating was positively correlated with BMI (r = 0.27, p = 0.001), and regular breakfast consumption was related to higher muscle mass percentage (beta = 0.23, p < 0.01, sr(2) = 0.05). Compared with non-sports-majoring students, sports-majoring students had longer weekday eating windows (11.2 +/- 2.8 h vs. 8.5 +/- 2.5 h, p < 0.001) and a higher dinner energy proportion (37.2 +/- 6.9% vs. 30.5 +/- 6.5%, p < 0.001). Males had later meal times and longer eating windows than females (breakfast: 7:58 vs. 7:46; dinner: 18:55 vs. 18:41; eating window: 11.5 h vs. 10.9 h; all p < 0.05). CONCLUSIONS: Chrononutrition was more closely associated with body composition than with absolute RMR in this predominantly sports-majoring sample of Chinese college students. Regular breakfast and reduced night eating are potential intervention targets for future chrononutrition guidance. However, the findings should be generalized to the broader college student population with caution. FAU - Xu, Kun AU - Xu K AD - Key Laboratory of the Ministry of Education of Exercise and Physical Fitness, School of Sport Science, Beijing Sport University, Beijing 100084, China. FAU - Yan, Shuo AU - Yan S AD - Key Laboratory of the Ministry of Education of Exercise and Physical Fitness, School of Sport Science, Beijing Sport University, Beijing 100084, China. FAU - Ji, Yuqin AU - Ji Y AD - Key Laboratory of the Ministry of Education of Exercise and Physical Fitness, School of Sport Science, Beijing Sport University, Beijing 100084, China. FAU - Meng, Yihan AU - Meng Y AD - Key Laboratory of the Ministry of Education of Exercise and Physical Fitness, School of Sport Science, Beijing Sport University, Beijing 100084, China. FAU - Li, Hongjuan AU - Li H AD - Key Laboratory of the Ministry of Education of Exercise and Physical Fitness, School of Sport Science, Beijing Sport University, Beijing 100084, China. LA - eng GR - 2023ZD0508500,2023ZD0508502/National Science and Technology Innovation 2030 Major Project "Major Special Project for Four Major Chronic Diseases"/ PT - Journal Article DEP - 20260411 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Female MH - *Basal Metabolism/physiology MH - *Body Composition/physiology MH - *Students/statistics & numerical data MH - Young Adult MH - Universities MH - *Feeding Behavior/physiology MH - Body Mass Index MH - Adolescent MH - Surveys and Questionnaires MH - Calorimetry, Indirect MH - Absorptiometry, Photon MH - Adult PMC - PMC13119362 OTO - NOTNLM OT - Chinese young adults OT - body composition OT - chrononutrition OT - resting metabolic rate OT - sports-majoring college students COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/05/04 06:33 MHDA- 2026/05/04 06:34 PMCR- 2026/04/11 CRDT- 2026/05/04 01:16 PHST- 2026/03/17 00:00 [received] PHST- 2026/04/09 00:00 [revised] PHST- 2026/04/10 00:00 [accepted] PHST- 2026/05/04 06:34 [medline] PHST- 2026/05/04 06:33 [pubmed] PHST- 2026/05/04 01:16 [entrez] PHST- 2026/04/11 00:00 [pmc-release] AID - nu18081214 [pii] AID - nutrients-18-01214 [pii] AID - 10.3390/nu18081214 [doi] PST - epublish SO - Nutrients. 2026 Apr 11;18(8):1214. doi: 10.3390/nu18081214. PMID- 42075023 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 8 DP - 2026 Apr 11 TI - Conditions for Knowledge and Application of Vegetarian/Vegan Diets Among Secondary School Students: A Cross-Sectional Study. LID - 10.3390/nu18081210 [doi] LID - 1210 AB - Background/Objectives: Knowledge of plant-based diets is gaining increasing significance in adolescents due to the growing popularity of vegetarian and vegan dietary patterns. To date, there has been limited research examining the level of awareness and understanding of these diets among secondary school students, as well as the factors influencing their knowledge. The aim of the study was to determine the prevalence of plant-based diets and to assess knowledge regarding these dietary patterns among high school students, as well as to identify factors associated with both diet adherence and achieving sufficient nutritional knowledge. Methods: A cross-sectional study was conducted among 341 high school students. Data were collected using a self-administered paper questionnaire that included demographic information, self-reported body weight and height, adherence to plant-based diets, and knowledge of vegetarian and vegan nutrition. Nutritional knowledge was assessed using a structured 19-item questionnaire (25 scorable items) and verified for reliability (test-retest, Krippendorff's alpha = 0.88). Based on a 25-point scale, a score of >60% (16-25 points) was categorized as 'sufficient' knowledge. Statistical analyses included the chi-square test, Mann-Whitney and Kruskal-Wallis non-parametric tests, and multivariable logistic regression to estimate adjusted odds ratios (aOR) for factors associated with sufficient knowledge. Results: The prevalence of plant-based diets in the study group was 16.1% (n = 55), with a significantly higher frequency observed among female students and those with sufficient nutritional knowledge. The majority of students (81.2%) achieved sufficient knowledge. Higher scores were observed among female students, those in higher grade levels, and those individuals adhering to plant-based diets (p < 0.05). Multivariate regression analysis indicated that male sex (aOR = 0.38 compared to females), higher grade level (aOR = 3.66 for grade 3 vs. grade 1; aOR = 3.62 for grade 4 vs. grade 1), residence in a rural area (aOR = 0.50), and non-adherence to a plant-based diet (aOR = 0.32) were independently associated with sufficient knowledge. Conclusions: The majority of high school students demonstrate sufficient knowledge regarding plant-based diets, with significant variations associated with sex, grade level, place of residence, and experience with plant-based diets. These findings underscore the need for targeted educational interventions, particularly among male students, those in lower grade levels, and individuals residing in rural areas. FAU - Kurzawska, Oliwia AU - Kurzawska O AD - Department of Human Nutrition, Faculty of Biotechnology and Food Science, Wroclaw University of Environmental and Life Sciences, 37 Chelmonskiego Street, 51-630 Wroclaw, Poland. FAU - Raczkowska, Ewa AU - Raczkowska E AUID- ORCID: 0000-0003-4205-1351 AD - Department of Human Nutrition, Faculty of Biotechnology and Food Science, Wroclaw University of Environmental and Life Sciences, 37 Chelmonskiego Street, 51-630 Wroclaw, Poland. LA - eng GR - The APC is financed by Wroclaw University of Environmental and Life Sciences./Wroclaw University of Environmental and Life Sciences/ PT - Journal Article DEP - 20260411 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - *Diet, Vegetarian/psychology MH - Adolescent MH - *Health Knowledge, Attitudes, Practice MH - Male MH - *Students/psychology MH - *Diet, Vegan/psychology MH - Surveys and Questionnaires MH - Schools PMC - PMC13118344 OTO - NOTNLM OT - BMI OT - adolescents OT - nutritional knowledge OT - plant-based diet OT - vegan diet OT - vegetarian diet COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:33 MHDA- 2026/05/04 06:34 PMCR- 2026/04/11 CRDT- 2026/05/04 01:16 PHST- 2026/02/16 00:00 [received] PHST- 2026/04/04 00:00 [revised] PHST- 2026/04/09 00:00 [accepted] PHST- 2026/05/04 06:34 [medline] PHST- 2026/05/04 06:33 [pubmed] PHST- 2026/05/04 01:16 [entrez] PHST- 2026/04/11 00:00 [pmc-release] AID - nu18081210 [pii] AID - nutrients-18-01210 [pii] AID - 10.3390/nu18081210 [doi] PST - epublish SO - Nutrients. 2026 Apr 11;18(8):1210. doi: 10.3390/nu18081210. PMID- 42075022 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260814 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 8 DP - 2026 Apr 11 TI - How to Teach Healthy Life-Style Efficiently in a Pediatric Outpatient Setting: Proposal of an Innovative Tridimensional Pyramid. LID - 10.3390/nu18081209 [doi] LID - 1209 AB - BACKGROUND: Childhood obesity is a major public health concern associated with adverse metabolic outcomes later in life. Despite increased awareness, unhealthy lifestyle behaviors-including suboptimal diet quality, physical inactivity, insufficient sleep, and unfavorable body composition-remain prevalent in pediatric populations. Effective, child-centered educational tools for early prevention are still limited. METHODS: We developed the Lifestyle Tridimensional Pyramid, an educational model integrating nutrition, physical activity, and sleep within a single, three-dimensional framework. The model also addresses body composition by emphasizing the balance between skeletal muscle and adipose tissue and the interdependence of lifestyle behaviors. This narrative review is supported by an umbrella review of 17 systematic reviews and meta-analyses published between 2010 and 2025, synthesizing evidence on lifestyle behaviors of pediatric obesity. RESULTS: High- to moderate-quality evidence indicates that adherence to Mediterranean-style dietary patterns, regular moderate-to-vigorous physical activity, adequate sleep duration, and a healthier body composition might prevent the development of obesity and improved cardiometabolic profiles in children and adolescents. The pyramid provides a structured, visually accessible tool to support lifestyle counseling in pediatric outpatient settings and is adaptable to school- and community-based health promotion. CONCLUSIONS: Although prospective validation studies are warranted, the Lifestyle Tridimensional Pyramid represents a practical, evidence-informed framework to support integrated lifestyle education and improve primary and secondary prevention of pediatric obesity. FAU - Mohn, Angelika Anna AU - Mohn AA AUID- ORCID: 0000-0002-6747-9306 AD - Departement of Pediatrics, University of Chieti, 65100 Chieti, Italy. AD - Clinical Research Center, "G.d'Annunzio" Foundation, University of Chieti, 65100 Chieti, Italy. FAU - Pietro, Giada Di AU - Pietro GD AD - Departement of Pediatrics, University of Chieti, 65100 Chieti, Italy. FAU - Maggitti, Alessandro AU - Maggitti A AD - Departement of Pediatrics, University of Chieti, 65100 Chieti, Italy. FAU - Trisi, Giulia AU - Trisi G AD - Departement of Pediatrics, University of Chieti, 65100 Chieti, Italy. FAU - Bucci, Ilaria AU - Bucci I AD - Departement of Pediatrics, University of Chieti, 65100 Chieti, Italy. FAU - Passarelli, Martina AU - Passarelli M AD - Departement of Pediatrics, University of Chieti, 65100 Chieti, Italy. FAU - Polidori, Nella AU - Polidori N AUID- ORCID: 0000-0001-7441-2655 AD - Departement of Pediatrics, University of Chieti, 65100 Chieti, Italy. FAU - Ludovico, Armando Di AU - Ludovico AD AUID- ORCID: 0000-0002-2644-1475 AD - Departement of Pediatrics, University of Chieti, 65100 Chieti, Italy. FAU - Chiarelli, Francesco AU - Chiarelli F AD - Departement of Pediatrics, University of Chieti, 65100 Chieti, Italy. AD - Clinical Research Center, "G.d'Annunzio" Foundation, University of Chieti, 65100 Chieti, Italy. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260411 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - *Healthy Lifestyle MH - Exercise MH - *Health Promotion/methods MH - *Pediatric Obesity/prevention & control MH - Sleep MH - Adolescent MH - Body Composition MH - Life Style MH - Health Behavior MH - Diet, Mediterranean PMC - PMC13119281 OTO - NOTNLM OT - Mediterranean diet OT - health promotion OT - lifestyle education OT - pediatric obesity OT - physical activity OT - sleep hygiene OT - tridimensional pyramid COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:32 MHDA- 2026/05/04 12:35 PMCR- 2026/04/11 CRDT- 2026/05/04 01:16 PHST- 2026/02/12 00:00 [received] PHST- 2026/04/05 00:00 [revised] PHST- 2026/04/08 00:00 [accepted] PHST- 2026/05/04 12:35 [medline] PHST- 2026/05/04 06:32 [pubmed] PHST- 2026/05/04 01:16 [entrez] PHST- 2026/04/11 00:00 [pmc-release] AID - nu18081209 [pii] AID - nutrients-18-01209 [pii] AID - 10.3390/nu18081209 [doi] PST - epublish SO - Nutrients. 2026 Apr 11;18(8):1209. doi: 10.3390/nu18081209. PMID- 42074931 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260504 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 8 DP - 2026 Apr 20 TI - Caring for the 'Heads-Down Generation': Screen Time and Physical Health Complaints Among Adolescents in Poland. LID - 10.3390/jcm15083130 [doi] LID - 3130 AB - Background/Objectives: Digital media play an important role in the lives of contemporary adolescents. While associated with many benefits, they also pose risks to physical health related to prolonged screen time and non-ergonomic body posture. This study analyzed the frequency of self-reported physical complaints among Polish adolescents in relation to time spent on different screen-based activities. Methods: The study included 9083 students aged 13-17 who completed an online survey in March and April 2024 in schools located in western Poland (approximately 30% of the region's student population). Physical symptoms selected from the HBSC-SCL instrument were analyzed and supplemented with neck or shoulder pain and eye strain. Results: Longer screen time was associated with more frequent occurrence of all analyzed complaints. A 5-item index ranging from 0 to 20 points was proposed, including headache, neck or shoulder pain, eye strain, dizziness, and problems falling asleep (mean 6.56 +/- 5.15). The index showed reliability at the level of alpha = 0.744 and good model fit according to CFA (RMSEA = 0.025). In a multivariate linear regression model (R(2) = 0.153), after adjusting for age, gender, place of residence, and family affluence, the variability of this index was most strongly associated with time spent on social media (beta = 0.40) and browsing websites (beta = 0.30). Gender-specific models were also compared. Conclusions: The results confirm the co-occurrence of physical complaints during adolescence and a significant association between their severity and screen-based activities, particularly engagement in social media. FAU - Mazur, Joanna AU - Mazur J AUID- ORCID: 0000-0002-3937-7230 AD - Department of Humanization of Medicine and Sexology, Collegium Medicum, University of Zielona Gora, 65-046 Zielona Gora, Poland. FAU - Kozakiewicz, Alicja AU - Kozakiewicz A AUID- ORCID: 0000-0001-6490-2511 AD - Department of Humanization of Medicine and Sexology, Collegium Medicum, University of Zielona Gora, 65-046 Zielona Gora, Poland. FAU - Porwit, Katarzyna AU - Porwit K AUID- ORCID: 0000-0002-2924-1268 AD - Centre of Migration Research, University of Warsaw, 02-093 Warsaw, Poland. FAU - Kleszczewska, Dorota AU - Kleszczewska D AUID- ORCID: 0000-0001-7523-8628 AD - Departament of Health Sociology, Education and Medical Communication, Institute of Mother and Child, 01-211 Warsaw, Poland. FAU - Bialorudzki, Maciej AU - Bialorudzki M AD - Department of Biomedical Aspects of Development and Sexology, Faculty of Education, University of Warsaw, 00-561 Warsaw, Poland. FAU - Izdebski, Zbigniew AU - Izdebski Z AUID- ORCID: 0000-0003-0165-1860 AD - Department of Humanization of Medicine and Sexology, Collegium Medicum, University of Zielona Gora, 65-046 Zielona Gora, Poland. AD - Department of Biomedical Aspects of Development and Sexology, Faculty of Education, University of Warsaw, 00-561 Warsaw, Poland. LA - eng PT - Journal Article DEP - 20260420 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13117625 OTO - NOTNLM OT - HBSC OT - adolescents OT - eye strain OT - musculoskeletal pain OT - physical health complaints OT - screen time OT - sedentary behavior OT - social media COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:33 MHDA- 2026/05/04 06:34 PMCR- 2026/04/20 CRDT- 2026/05/04 01:16 PHST- 2026/03/13 00:00 [received] PHST- 2026/04/16 00:00 [revised] PHST- 2026/04/17 00:00 [accepted] PHST- 2026/05/04 06:34 [medline] PHST- 2026/05/04 06:33 [pubmed] PHST- 2026/05/04 01:16 [entrez] PHST- 2026/04/20 00:00 [pmc-release] AID - jcm15083130 [pii] AID - jcm-15-03130 [pii] AID - 10.3390/jcm15083130 [doi] PST - epublish SO - J Clin Med. 2026 Apr 20;15(8):3130. doi: 10.3390/jcm15083130. PMID- 42074422 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 23 IP - 4 DP - 2026 Apr 11 TI - DEMETRA: An ACT-Based Virtual Coach to Support Healthier Lifestyles in Overweight Pregnant Women-Protocol for a Feasibility Pilot Study. LID - 10.3390/ijerph23040483 [doi] LID - 483 AB - During pregnancy, women are more inclined to modify their habits and lifestyle to find a new balance and promote well-being for themselves and the child-to-be. However, the availability of nutritional and psychological support is often limited by stigma, geographic barriers, and a lack of services. Digital health tools are emerging as possible solutions to cover these needs. This study explores the acceptability, feasibility, and user experience of Demetra, a virtual coach based on Acceptance and Commitment Therapy (ACT), designed to promote healthy lifestyles and mental well-being. Fifty pregnant women will be enrolled in the feasibility study of the intervention. It starts with an educational part on the foundations of healthy eating and suggestions about lifestyle habits, followed by a six-week psychoeducational module. Content is delivered through text, audio, and video formats. User experience and engagement will be measured through validated questionnaires and semi-structured interviews. Psychological well-being will be evaluated both before and after the program. The intervention is expected to be well-received, with high levels of satisfaction and engagement, leading to a greater awareness of healthy behaviors, improved psychological flexibility, and enhanced overall well-being. Demetra offers an accessible solution to support women through the transformative experience of motherhood with a multidisciplinary and innovative approach. FAU - Nicoletti, Anna Elena AU - Nicoletti AE AUID- ORCID: 0009-0000-4051-6341 AD - Digital Health Research, Centre for Digital Health & Wellbeing, Fondazione Bruno Kessler, Via Sommarive 18, 38123 Trento, Italy. FAU - Purin, Barbara AU - Purin B AUID- ORCID: 0000-0003-1913-6998 AD - Digital Health Research, Centre for Digital Health & Wellbeing, Fondazione Bruno Kessler, Via Sommarive 18, 38123 Trento, Italy. FAU - Rizzi, Silvia AU - Rizzi S AUID- ORCID: 0000-0002-8610-2432 AD - Digital Health Research, Centre for Digital Health & Wellbeing, Fondazione Bruno Kessler, Via Sommarive 18, 38123 Trento, Italy. FAU - Dalmonego, Carlo AU - Dalmonego C AD - Digital Health Research, Centre for Digital Health & Wellbeing, Fondazione Bruno Kessler, Via Sommarive 18, 38123 Trento, Italy. FAU - Bezzeccheri, Anna AU - Bezzeccheri A AD - Digital Health Research, Centre for Digital Health & Wellbeing, Fondazione Bruno Kessler, Via Sommarive 18, 38123 Trento, Italy. FAU - Corradini, Silvia AU - Corradini S AD - Digital Health Research, Centre for Digital Health & Wellbeing, Fondazione Bruno Kessler, Via Sommarive 18, 38123 Trento, Italy. FAU - Poggianella, Stefania AU - Poggianella S AUID- ORCID: 0000-0001-6271-6037 AD - Digital Health Research, Centre for Digital Health & Wellbeing, Fondazione Bruno Kessler, Via Sommarive 18, 38123 Trento, Italy. FAU - Paoli, Claudia AU - Paoli C AUID- ORCID: 0009-0003-9668-5234 AD - Transmural Obstetric Gynecological Department, Healthcare Trust of the Autonomous Province of Trento (APSS), 38122 Trento, Italy. FAU - Burlon, Barbara AU - Burlon B AD - Transmural Obstetric Gynecological Department, Healthcare Trust of the Autonomous Province of Trento (APSS), 38122 Trento, Italy. FAU - Zorzi, Marina AU - Zorzi M AD - Transmural Obstetric Gynecological Department, Healthcare Trust of the Autonomous Province of Trento (APSS), 38122 Trento, Italy. FAU - Lazzari, Cecilia AU - Lazzari C AD - Transmural Obstetric Gynecological Department, Healthcare Trust of the Autonomous Province of Trento (APSS), 38122 Trento, Italy. FAU - Depaoli, Stefania AU - Depaoli S AD - Transmural Obstetric Gynecological Department, Healthcare Trust of the Autonomous Province of Trento (APSS), 38122 Trento, Italy. FAU - Fronza, Ornella AU - Fronza O AD - Transmural Obstetric Gynecological Department, Healthcare Trust of the Autonomous Province of Trento (APSS), 38122 Trento, Italy. FAU - Lorenzato, Enrica AU - Lorenzato E AD - Transmural Obstetric Gynecological Department, Healthcare Trust of the Autonomous Province of Trento (APSS), 38122 Trento, Italy. FAU - Marroni, Debora AU - Marroni D AD - Operating Unit of Psychology, Healthcare Trust of the Autonomous Province of Trento (APSS), 38122 Trento, Italy. FAU - Forti, Stefano AU - Forti S AD - Digital Health Research, Centre for Digital Health & Wellbeing, Fondazione Bruno Kessler, Via Sommarive 18, 38123 Trento, Italy. FAU - Taddei, Fabrizio AU - Taddei F AD - Transmural Obstetric Gynecological Department, Healthcare Trust of the Autonomous Province of Trento (APSS), 38122 Trento, Italy. LA - eng PT - Journal Article DEP - 20260411 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Pilot Projects MH - Feasibility Studies MH - *Overweight/therapy/psychology MH - *Healthy Lifestyle MH - *Health Promotion/methods MH - *Pregnant People MH - Adult PMC - PMC13116530 OTO - NOTNLM OT - ACT OT - digital intervention OT - eHealth OT - healthy eating OT - healthy lifestyles OT - mental well-being OT - overweight OT - pregnancy OT - usability OT - user-centred design COIS- Anna Elena Nicoletti was employed by Fondazione Bruno Kessler. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationship that could be construed as a potential conflict of interest. EDAT- 2026/05/04 06:33 MHDA- 2026/05/04 06:34 PMCR- 2026/04/11 CRDT- 2026/05/04 01:14 PHST- 2025/07/15 00:00 [received] PHST- 2025/08/12 00:00 [revised] PHST- 2026/04/09 00:00 [accepted] PHST- 2026/05/04 06:34 [medline] PHST- 2026/05/04 06:33 [pubmed] PHST- 2026/05/04 01:14 [entrez] PHST- 2026/04/11 00:00 [pmc-release] AID - ijerph23040483 [pii] AID - ijerph-23-00483 [pii] AID - 10.3390/ijerph23040483 [doi] PST - epublish SO - Int J Environ Res Public Health. 2026 Apr 11;23(4):483. doi: 10.3390/ijerph23040483. PMID- 42073428 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260504 LR - 20260813 IS - 2075-1729 (Print) IS - 2075-1729 (Electronic) IS - 2075-1729 (Linking) VI - 16 IP - 4 DP - 2026 Apr 7 TI - The Relationship Between Eating Habits and Anthropometric Values in High School Adolescents. LID - 10.3390/life16040618 [doi] LID - 618 AB - Objectives: The present study aimed to examine the relationship between dietary habits and anthropometric characteristics of high school adolescents. Participants and Methods: This cross-sectional study involved randomly selecting 104 students (34 boys and 70 girls) who were 17-19 years old. To evaluate dietary habits, a validated and standardized EPIC-Norfolk frequency food questionnaire was used, and anthropometric characteristics of the participants were assessed. Results: The most often consumed foods during the week were meats and fruits, while the least frequently consumed were fish and vegetables. For all participants, intake below the recommended levels was for alpha-carotene, total carbohydrate sugars, vitamin D, milk, dairy products, nuts, and seeds. Intake of proteins and iron was below the recommended levels in girls. Boys had a lower intake of proteins and fruits compared to girls. No differences were observed in the consumption of macronutrients. The median of all anthropometric values was within the reference values. Boys were slightly older and had significantly higher values of body weight and height, BMI, waist circumference, and waist-to-hip-ratio (WHR) compared to girls. In addition, systolic blood pressure (SBP) was significantly higher in males than in females. Participants with increased arterial blood pressure (ABP) showed significantly higher energy intake from fat, sodium intake, and total fat intake compared to those with normal ABP. Participants with increased WHR had significantly higher energy intake, intake of sodium, and total carbohydrates compared to those with normal WHR. Conclusions: This study shows that adolescents' eating habits (particularly intake of fat and sodium) were associated with anthropometric values, ABP, and WHR, which present risks for cardiometabolic diseases in adulthood. FAU - Firi, Lucija AU - Firi L AD - Health Centre Osijek-Baranja County, 31000 Osijek, Croatia. FAU - Mihaljevic, Dubravka AU - Mihaljevic D AUID- ORCID: 0000-0002-0051-4154 AD - Department of Nephrology, Clinical Hospital Centre Osijek, J. Huttlera 4, 31000 Osijek, Croatia. FAU - Prosic, Ivan AU - Prosic I AD - General Hospital Nasice, 31500 Nasice, Croatia. FAU - Kralik, Kristina AU - Kralik K AUID- ORCID: 0000-0002-4481-6365 AD - Department of Medical Statistics and Medical Informatics, Faculty of Medicine Osijek, University Josip Juraj Strossmayer Osijek, J. Huttlera 4, 31000 Osijek, Croatia. FAU - Stupin, Ana AU - Stupin A AUID- ORCID: 0000-0002-7446-0021 AD - Department of Physiology and Immunology, Faculty of Medicine Osijek, University Josip Juraj Strossmayer Osijek, J. Huttlera 4, 31000 Osijek, Croatia. FAU - Jukic, Ivana AU - Jukic I AUID- ORCID: 0000-0003-3795-2112 AD - Department of Physiology and Immunology, Faculty of Medicine Osijek, University Josip Juraj Strossmayer Osijek, J. Huttlera 4, 31000 Osijek, Croatia. FAU - Drenjancevic, Ines AU - Drenjancevic I AUID- ORCID: 0000-0003-4964-7721 AD - Department of Physiology and Immunology, Faculty of Medicine Osijek, University Josip Juraj Strossmayer Osijek, J. Huttlera 4, 31000 Osijek, Croatia. LA - eng GR - IP18-MEFOS_2024 and IP20-MEFOS-2025/Faculty of Medicine Osijek/ PT - Journal Article DEP - 20260407 PL - Switzerland TA - Life (Basel) JT - Life (Basel, Switzerland) JID - 101580444 PMC - PMC13117922 OTO - NOTNLM OT - anthropometry OT - body mass index OT - dietary habits OT - waist-hip ratio COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:32 MHDA- 2026/05/04 06:33 PMCR- 2026/04/07 CRDT- 2026/05/04 01:10 PHST- 2026/02/27 00:00 [received] PHST- 2026/03/15 00:00 [revised] PHST- 2026/04/03 00:00 [accepted] PHST- 2026/05/04 06:33 [medline] PHST- 2026/05/04 06:32 [pubmed] PHST- 2026/05/04 01:10 [entrez] PHST- 2026/04/07 00:00 [pmc-release] AID - life16040618 [pii] AID - life-16-00618 [pii] AID - 10.3390/life16040618 [doi] PST - epublish SO - Life (Basel). 2026 Apr 7;16(4):618. doi: 10.3390/life16040618. PMID- 42072787 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260504 LR - 20260813 IS - 2075-4418 (Print) IS - 2075-4418 (Electronic) IS - 2075-4418 (Linking) VI - 16 IP - 8 DP - 2026 Apr 14 TI - Physical Activity Patterns and Cardiometabolic Risk in Children and Adolescents with Obesity: A Cross-Sectional Study. LID - 10.3390/diagnostics16081162 [doi] LID - 1162 AB - Introduction: Childhood and adolescent obesity is a growing global health challenge associated with early metabolic and cardiovascular complications. This study aims to compare questionnaire-assessed physical activity patterns and lifestyle characteristics among children and adolescents with obesity and normal-weight peers and to explore their associations with clinical measurements and cardiometabolic risk. Assessing resting metabolic rate (RMR) by indirect calorimetry may provide additional insight into metabolic status beyond conventional anthropometric indicators. Methods: This prospective cross-sectional study included 58 children and adolescents aged 5-18 years with obesity and 30 normal-weight controls evaluated in Sfanta Maria Emergency Children's Hospital Iasi, Romania. Clinical data included anthropometric measurements and available biochemical parameters. RMR was assessed through indirect calorimetry (Fitmate Pro, Cosmed, Rome, Italy). Parents completed a structured lifestyle questionnaire adapted from validated international instruments, collecting information on physical activity, sedentary behavior, and wearable device use. Data analysis was conducted using SPSS 22.0, applying descriptive statistics and Pearson correlation analysis. Results: Children with obesity reported higher body mass index (BMI) (30.48 +/- 5.31 kg/m(2)), higher RMR values, lower physical activity levels and greater sedentary time than controls. RMR correlated positively with BMI, central adiposity, blood pressure, waist-to-height, hepatic steatosis and exercise tolerance. Although electronic devices for monitoring physical activity were more frequently used in the obesity group, this was not associated with higher activity levels. Conclusions: Children and adolescents with obesity exhibited a clustered cardiometabolic risk profile and reduced physical activity. RMR measured by indirect calorimetry may contribute to a more comprehensive metabolic assessment in pediatric obesity. FAU - Manole, Lorena Mihaela AU - Manole LM AUID- ORCID: 0009-0003-6798-9984 AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. FAU - Tarca, Elena AU - Tarca E AUID- ORCID: 0000-0002-3018-8011 AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. AD - Sfanta Maria Emergency Children Hospital, 700309 Iasi, Romania. FAU - Spoiala, Elena-Lia AU - Spoiala EL AUID- ORCID: 0000-0002-7015-0085 AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. AD - Sfanta Maria Emergency Children Hospital, 700309 Iasi, Romania. FAU - Boca, Laura Otilia AU - Boca LO AUID- ORCID: 0009-0007-1062-9995 AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. AD - Sfanta Maria Emergency Children Hospital, 700309 Iasi, Romania. FAU - Donos, Madalina Andreea AU - Donos MA AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. AD - Sfanta Maria Emergency Children Hospital, 700309 Iasi, Romania. FAU - Paduraru, Gabriela AU - Paduraru G AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. AD - Sfanta Maria Emergency Children Hospital, 700309 Iasi, Romania. FAU - Ghiga, Gabriela AU - Ghiga G AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. AD - Sfanta Maria Emergency Children Hospital, 700309 Iasi, Romania. FAU - Tarca, Viorel AU - Tarca V AD - Faculty of Medicine, Apollonia University, 700511 Iasi, Romania. FAU - Pinzariu, Alin Constantin AU - Pinzariu AC AUID- ORCID: 0000-0001-5730-1662 AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. FAU - Trandafir, Laura Mihaela AU - Trandafir LM AUID- ORCID: 0000-0002-8326-7610 AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. AD - Sfanta Maria Emergency Children Hospital, 700309 Iasi, Romania. LA - eng PT - Journal Article DEP - 20260414 PL - Switzerland TA - Diagnostics (Basel) JT - Diagnostics (Basel, Switzerland) JID - 101658402 PMC - PMC13115053 OTO - NOTNLM OT - adolescent OT - cardiometabolic risk OT - child OT - digital health OT - obesity OT - physical activity OT - sedentary behavior OT - wearable devices COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:32 MHDA- 2026/05/04 06:33 PMCR- 2026/04/14 CRDT- 2026/05/04 01:08 PHST- 2026/03/08 00:00 [received] PHST- 2026/04/04 00:00 [revised] PHST- 2026/04/09 00:00 [accepted] PHST- 2026/05/04 06:33 [medline] PHST- 2026/05/04 06:32 [pubmed] PHST- 2026/05/04 01:08 [entrez] PHST- 2026/04/14 00:00 [pmc-release] AID - diagnostics16081162 [pii] AID - diagnostics-16-01162 [pii] AID - 10.3390/diagnostics16081162 [doi] PST - epublish SO - Diagnostics (Basel). 2026 Apr 14;16(8):1162. doi: 10.3390/diagnostics16081162. PMID- 42070968 OWN - NLM STAT- MEDLINE DCOM- 20260610 LR - 20260610 IS - 2191-0251 (Electronic) IS - 0334-018X (Linking) VI - 39 IP - 5 DP - 2026 May 26 TI - Automatic bone age assessment for adult height prediction in children with congenital adrenal hyperplasia. PG - 464-471 LID - 10.1515/jpem-2026-0101 [doi] AB - OBJECTIVES: This study aimed to evaluate the clinical accuracy of automated BoneXpert (BX) vs. clinician-based Greulich-Pyle (GP) bone age (BA) assessments by comparing their respective predicted adult heights (PAH) with near-final height (NFH) in patients with congenital adrenal hyperplasia (CAH). METHODS: Forty-seven patients with classic salt-wasting CAH diagnosed in the neonatal period who had reached NFH were included. Left hand-wrist radiographs obtained during the prepubertal period (6-9 years) were evaluated manually by two clinicians using the GP atlas and by the BX-GP method. PAH was calculated for both sexes using the Bayley-Pinneau (BP) method based on clinician- and BX-derived BA. PAH standard deviation scores (SDS) were compared with NFH-SDS and target height (TH)-SDS. Agreement was assessed using Bland-Altman analysis. RESULTS: Thirty patients (63.8 %) were female. Mean ages at bone age assessment and NFH were 7.3 and 16.1 years, respectively. Mean prepubertal height-SDS was 0.0 in girls and -0.25 in boys, while NFH-SDS was -0.79 and -1.14, respectively. Mean bone age according to clinician-GP was 7.80 years in girls and 8.16 in boys, and 7.69 and 8.14 years according to BX-GP. Clinician-based PAH-SDS was -1.0 in girls and -1.18 in boys, whereas BX-based PAH-SDS was -0.86 and -1.17, respectively. BX-based PAH was closer to NFH in girls (p<0.001), with no significant difference in boys. In both sexes, PAH-SDS and NFH-SDS were significantly lower than TH-SDS (p<0.001). CONCLUSIONS: PAH calculations using the BP method based on BX-derived GP bone age readings more accurately predicted NFH in patients with CAH. CI - (c) 2026 Walter de Gruyter GmbH, Berlin/Boston. FAU - Cetin, Kursat AU - Cetin K AUID- ORCID: 0000-0002-9022-4010 AD - Department of Pediatric Endocrinology, Akdeniz University Hospital, Antalya, Turkiye. FAU - Cetiner, Ebru Barsal AU - Cetiner EB AUID- ORCID: 0000-0002-1888-919X AD - Department of Pediatric Endocrinology, Akdeniz University Hospital, Antalya, Turkiye. FAU - Bahar, Yasemin Funda AU - Bahar YF AUID- ORCID: 0000-0001-9022-5294 AD - Department of Pediatric Endocrinology, Akdeniz University Hospital, Antalya, Turkiye. FAU - Tirtar, Ali AU - Tirtar A AUID- ORCID: 0009-0001-9924-9775 AD - Department of Pediatric Endocrinology, Akdeniz University Hospital, Antalya, Turkiye. FAU - Parlak, Mesut AU - Parlak M AUID- ORCID: 0000-0002-3550-1425 AD - Department of Pediatric Endocrinology, Akdeniz University Hospital, Antalya, Turkiye. FAU - Tuhan, Hale AU - Tuhan H AUID- ORCID: 0000-0002-7637-9630 AD - Department of Pediatric Endocrinology, Akdeniz University Hospital, Antalya, Turkiye. LA - eng PT - Journal Article DEP - 20260505 PL - Germany TA - J Pediatr Endocrinol Metab JT - Journal of pediatric endocrinology & metabolism : JPEM JID - 9508900 SB - IM MH - Humans MH - *Adrenal Hyperplasia, Congenital/physiopathology MH - Male MH - Female MH - Child MH - *Body Height MH - *Age Determination by Skeleton/methods MH - Adolescent MH - Prognosis MH - Follow-Up Studies OTO - NOTNLM OT - BoneXpert OT - bone age OT - congenital adrenal hyperplasia OT - near final height OT - predicted adult height EDAT- 2026/05/04 00:31 MHDA- 2026/06/11 05:43 CRDT- 2026/05/03 22:02 PHST- 2026/02/13 00:00 [received] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/06/11 05:43 [medline] PHST- 2026/05/04 00:31 [pubmed] PHST- 2026/05/03 22:02 [entrez] AID - jpem-2026-0101 [pii] AID - 10.1515/jpem-2026-0101 [doi] PST - epublish SO - J Pediatr Endocrinol Metab. 2026 May 5;39(5):464-471. doi: 10.1515/jpem-2026-0101. Print 2026 May 26. PMID- 42069593 OWN - NLM STAT- MEDLINE DCOM- 20260622 LR - 20260813 IS - 1475-9276 (Electronic) IS - 1475-9276 (Linking) VI - 25 IP - 1 DP - 2026 May 2 TI - Experiences of discrimination, paternal support, and hypertensive disorders of pregnancy (HDP) in the MIEHR study, Houston, Texas. LID - 10.1186/s12939-026-02864-5 [doi] LID - 154 AB - BACKGROUND: Discrimination is a psychosocial stressor that, through activation of stress-response pathways, may influence risk of adverse perinatal health outcomes. However, few studies have evaluated the association between discrimination and hypertensive disorders of pregnancy (HDP), and none have explored effect modification by race or paternal support, which may buffer the adverse effects of discrimination. METHODS: We included 1,847 non-Hispanic Black and White participants from the Maternal and Infant Environmental Health Riskscape (MIEHR) study. Krieger's validated Experiences of Discrimination (EOD) scale was used to assess occurrence (yes/no) and frequency (once, 2-3, >/= 4 times) of discrimination in nine situations. We created continuous scores representing total situations and frequency and also categorized (0, 1-2, >/= 3) the situations score. Using electronic health records, we identified participants with HDP (hypertension in pregnancy, preeclampsia, eclampsia, and hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome). We applied log-binomial regression to evaluate associations between experiences of discrimination and HDP, adjusted for maternal age, pre-pregnancy body mass index, income, and race. Analyses were stratified by race and self-reported paternal support (none/a little vs. good/excellent) as potential effect modifiers; due to small numbers, the situation score was dichotomized (0, >/= 1) for these analyses. RESULTS: HDP occurred in 37.5% (n = 430) of Black and 26.0% (n = 182) of White participants. Compared with participants reporting no discrimination, the adjusted risk ratio (aRR) was 1.13 (95% CI: 0.96, 1.33) and 1.11 (95% CI: 0.94, 1.30) for those reporting discrimination in 1-2 and >/= 3 situations, respectively. By setting, the strongest associations were observed for discrimination in getting a job (aRR: 1.22; 95% CI: 1.14, 1.43), by police (aRR: 1.21; 95% CI: 1.01, 1.44), and getting medical care (aRR: 1.17; 95% CI: 0.94, 1.44). Stratified analyses revealed the strongest associations between experiencing discrimination and HDP among Black participants and those with lower perceptions of paternal support. CONCLUSIONS: We found associations between discrimination and HDP among Black participants, who bear the greatest burden of HDP, as well as a potential buffering effect of paternal support. Future research is needed to investigate associations between discrimination and HDP and evaluate whether enhancing paternal support can mitigate the impact of discrimination on HDP risk. CI - (c) 2026. The Author(s). FAU - Alinia, Tahereh AU - Alinia T AD - Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA. FAU - Symanski, Elaine AU - Symanski E AD - Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA. AD - Department of Medicine, Section of Epidemiology and Population Sciences, Baylor College of Medicine, Houston, TX, USA. FAU - Alvarez, Juan Manuel AU - Alvarez JM AD - Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA. FAU - Whitworth, Kristina Walker AU - Whitworth KW AD - Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA. kristina.whitworth@bcm.edu. AD - Department of Medicine, Section of Epidemiology and Population Sciences, Baylor College of Medicine, Houston, TX, USA. kristina.whitworth@bcm.edu. LA - eng GR - P50 MD015496/MD/NIMHD NIH HHS/United States PT - Journal Article DEP - 20260502 PL - England TA - Int J Equity Health JT - International journal for equity in health JID - 101147692 SB - IM MH - Adult MH - Female MH - Humans MH - Male MH - Pregnancy MH - Black or African American/psychology MH - *Fathers/psychology MH - *Hypertension, Pregnancy-Induced/epidemiology/ethnology/psychology MH - *Racism MH - Texas/epidemiology MH - White/psychology PMC - PMC13285525 OTO - NOTNLM OT - Discrimination OT - Hypertensive disorders of pregnancy OT - Paternal support OT - Race COIS- Declarations. Ethics approval and consent to participate: The study protocol was approved by the Institutional Review Boards at Baylor College of Medicine and The University of Texas Health Science Center at Houston. Informed consent was obtained from all participants in this study. The research was conducted in accordance with the principles of the Belmont Report and the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/03 05:27 MHDA- 2026/06/22 18:58 PMCR- 2026/05/02 CRDT- 2026/05/02 23:15 PHST- 2025/08/21 00:00 [received] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/06/22 18:58 [medline] PHST- 2026/05/03 05:27 [pubmed] PHST- 2026/05/02 23:15 [entrez] PHST- 2026/05/02 00:00 [pmc-release] AID - 10.1186/s12939-026-02864-5 [pii] AID - 2864 [pii] AID - 10.1186/s12939-026-02864-5 [doi] PST - epublish SO - Int J Equity Health. 2026 May 2;25(1):154. doi: 10.1186/s12939-026-02864-5. PMID- 42069557 OWN - NLM STAT- MEDLINE DCOM- 20260619 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 May 2 TI - The study protocol of the ePro-Schools project: an eHealth program for promoting physical activity and healthy nutrition in schools. LID - 10.1186/s12889-026-27587-8 [doi] LID - 1922 AB - BACKGROUND: Early adolescence is key for adopting healthier lifestyles, yet disadvantaged communities often lack resources to support these changes, perpetuating health inequities. Schools play a crucial role in promoting physical activity and healthy eating. eHealth solutions, like online platforms, offer scalable, cost-effective ways to deliver interventions. These platforms can also enhance adolescent engagement and help bridge health resource gaps. The ePro-Schools project aims to co-design and test an eHealth platform to promote healthy habits among adolescents in socially disadvantaged settings. METHODS: A randomized controlled trial (RCT) will be carried out with the participation of 6 secondary schools (three controls and three intervention), with a sample size estimated at 1000 students of Central Catalonia (Spain). In the intervention schools, focus groups sessions and meetings with stakeholders have been conducted to co-create the ePro-Schools eHealth platform. Students and school staff are pilot testing the platform to assess the platform's usability, functionality, and layout. Finally, the RCT will be conducted, in which the intervention group will have full access to the ePro-Schools platform (an interactive and informative platform), while the control group will only have access to the informative platform with health literacy content on physical activity, nutrition, and healthy habits. In both groups, adolescents will complete validated questionnaires at baseline, post-intervention, and at the six-month follow-up to assess their physical activity and eating habits, including depressive symptoms, quality of life, social isolation, and mental health. Sociodemographic characteristics will also be collected. Implementation, effectiveness, and cost-effectiveness analysis will be performed. DISCUSSION: The ePro-Schools project introduces a co-designed eHealth platform that integrates physical activity and healthy eating promotion within schools. The intervention aims to enhance adoption, relevance, and sustainability across diverse settings. ePro-Schools project could reduce health inequalities, improve adolescents' physical and mental well-being, and strengthen daily health habits. The model's scalability and embedded implementation planning may support long-term integration into school systems, informing future policies and contributing to educational engagement, reduced disease risk, and broader population health impact. TRIAL REGISTRATION: This trial is registered in ClinicalTrials.gov, with the registration number NCT06792461. CI - (c) 2026. The Author(s). FAU - Mas, Eugeni AU - Mas E AD - Unitat de Suport a La Recerca de La Catalunya Central, Institut Universitari Per a La Recerca a L'Atencio Primaria de Salut Jordi Gol I Gurina (IDIAPJGol), Manresa, Spain. FAU - Moreno-Martinez, Marina AU - Moreno-Martinez M AD - Unitat de Recerca I Innovacio, Gerencia d'Atencio Primaria I a La Comunitat de La Catalunya Central, Institut Catala de La Salut, Soler I March Street, 6, 5th floor, 08242, Barcelona, Manresa, Spain. mmorenom.cc.ics@gencat.cat. AD - Intelligence for Primary Care Research Group, Fundacio Institut Universitari Per a La Recerca a L'Atencio Primaria de Salut Jordi Gol I Gurina, Manresa, Spain. mmorenom.cc.ics@gencat.cat. FAU - Gascon, Mireia AU - Gascon M AD - Unitat de Suport a La Recerca de La Catalunya Central, Institut Universitari Per a La Recerca a L'Atencio Primaria de Salut Jordi Gol I Gurina (IDIAPJGol), Manresa, Spain. FAU - Espelt, Albert AU - Espelt A AD - Consorcio Centro Investigacion Biomedica en RED (CIBER)-SAM and Impact and Prevention of Mental Disorders, Barcelona, Spain. AD - Universitat Autonoma de Barcelona (UAB), Barcelona, Spain. FAU - Pryss, Rudiger AU - Pryss R AD - Institute of Medical Data Science, University Hospital Wurzburg, Wurzburg, Germany. AD - Institute of Clinical Epidemiology and Biometry, University of Wurzburg, Wurzburg, Germany. FAU - van der Waerden, Judith AU - van der Waerden J AD - Sorbonne Universite, INSERM, Institut Pierre Louis d'Epidemiologie Et de Sante Publique (IPLESP), Epidemiologie Sociale, Sante Mentale Et Addictions (ESSMA), Paris, France. FAU - Pilato, Jade AU - Pilato J AD - Sorbonne Universite, INSERM, Institut Pierre Louis d'Epidemiologie Et de Sante Publique (IPLESP), Epidemiologie Sociale, Sante Mentale Et Addictions (ESSMA), Paris, France. FAU - Agostinis-Sobrinho, Cesar AU - Agostinis-Sobrinho C AD - Health Research and Innovation Science Centre, Klaipeda University, Klaipeda, Lithuania. FAU - Stevens, Gonneke AU - Stevens G AD - Department of Interdisciplinary Social Science (UU), Utrecht University, Utrecht, Netherlands. FAU - Gobina, Inese AU - Gobina I AD - Insitute of Public Health, Rigas Stradins Universitaty (RSU), Riga, Latvia. FAU - Kraft, Robin AU - Kraft R AD - Institute of Medical Data Science, University Hospital Wurzburg, Wurzburg, Germany. AD - Institute of Clinical Epidemiology and Biometry, University of Wurzburg, Wurzburg, Germany. FAU - Vogel, Carsten AU - Vogel C AD - Institute of Medical Data Science, University Hospital Wurzburg, Wurzburg, Germany. AD - Institute of Clinical Epidemiology and Biometry, University of Wurzburg, Wurzburg, Germany. FAU - Stach, Michael AU - Stach M AD - Institute of Medical Data Science, University Hospital Wurzburg, Wurzburg, Germany. AD - Institute of Clinical Epidemiology and Biometry, University of Wurzburg, Wurzburg, Germany. FAU - Koehler, Karsten AU - Koehler K AD - Department of Health and Sport Sciences, Technical University of Munich, Munich, Germany. FAU - Perez-Anton, Mariona AU - Perez-Anton M AD - Parc Sanitari Sant Joan de Deu, Barcelona, Spain. AD - Impact and Prevention of Mental Disorders Research Group, Sant Joan de Deu Research Institute, Barcelona, Spain. FAU - Sanguesa, Julia AU - Sanguesa J AD - Parc Sanitari Sant Joan de Deu, Barcelona, Spain. AD - Impact and Prevention of Mental Disorders Research Group, Sant Joan de Deu Research Institute, Barcelona, Spain. FAU - Melo, Geiziane AU - Melo G AD - Health Research and Innovation Science Centre, Klaipeda University, Klaipeda, Lithuania. FAU - Espirito Santo, Rafaela C AU - Espirito Santo RC AD - Health Research and Innovation Science Centre, Klaipeda University, Klaipeda, Lithuania. FAU - Haro, Josep Maria AU - Haro JM AD - Consorcio Centro Investigacion Biomedica en RED (CIBER)-SAM and Impact and Prevention of Mental Disorders, Barcelona, Spain. AD - Parc Sanitari Sant Joan de Deu, Barcelona, Spain. AD - Impact and Prevention of Mental Disorders Research Group, Sant Joan de Deu Research Institute, Barcelona, Spain. FAU - Bosque-Prous, Marina AU - Bosque-Prous M AD - Research Group in Epidemiology and Public Health in the Digital Health Context (Epi4health), Faculty of Health Sciences, Universitat Oberta de Catalunya, Barcelona, Spain. AD - Department of Psychobiology and Methodology in Health Sciences, Universitat Autonoma de Barcelona (UAB), Bellaterra, Spain. AD - Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain. FAU - Aguilar-Martinez, Alicia AU - Aguilar-Martinez A AD - Research Group in Epidemiology and Public Health in the Digital Health Context (Epi4health), Faculty of Health Sciences, Universitat Oberta de Catalunya, Barcelona, Spain. FAU - Esquius, Laura AU - Esquius L AD - Research Group in Epidemiology and Public Health in the Digital Health Context (Epi4health), Faculty of Health Sciences, Universitat Oberta de Catalunya, Barcelona, Spain. FAU - Massip-Salcedo, Marta AU - Massip-Salcedo M AD - Research Group in Epidemiology and Public Health in the Digital Health Context (Epi4health), Faculty of Health Sciences, Universitat Oberta de Catalunya, Barcelona, Spain. AD - Barcelona Beta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Catalonia, Spain. FAU - Chiva-Blanch, Gemma AU - Chiva-Blanch G AD - NUTRALiSS Research Group, Faculty of Health Sciences, Universitat Oberta de Catalunya (UOC), Barcelona, Spain. AD - Biomedical Network Research Centre On Obesity and Nutrition Physiopathology (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. FAU - Vidal-Alaball, Josep AU - Vidal-Alaball J AD - Unitat de Suport a La Recerca de La Catalunya Central, Institut Universitari Per a La Recerca a L'Atencio Primaria de Salut Jordi Gol I Gurina (IDIAPJGol), Manresa, Spain. AD - Unitat de Recerca I Innovacio, Gerencia d'Atencio Primaria I a La Comunitat de La Catalunya Central, Institut Catala de La Salut, Soler I March Street, 6, 5th floor, 08242, Barcelona, Manresa, Spain. AD - Intelligence for Primary Care Research Group, Fundacio Institut Universitari Per a La Recerca a L'Atencio Primaria de Salut Jordi Gol I Gurina, Manresa, Spain. AD - Department of Medicine, Faculty of Medicine, University of Vic-Central, University of Catalonia, Vic, Spain. FAU - Lima, Rodrigo AU - Lima R AD - Consorcio Centro Investigacion Biomedica en RED (CIBER)-SAM and Impact and Prevention of Mental Disorders, Barcelona, Spain. AD - Parc Sanitari Sant Joan de Deu, Barcelona, Spain. AD - Impact and Prevention of Mental Disorders Research Group, Sant Joan de Deu Research Institute, Barcelona, Spain. LA - eng SI - ClinicalTrials.gov/NCT06792461 GR - GA N degrees 101095426/Instituto de Salud Carlos III (ISC-III) under the umbrella of the Partnership Fostering a European Research Area for Health (ERA4Health)/ PT - Clinical Trial Protocol PT - Journal Article DEP - 20260502 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - *Diet, Healthy MH - *Exercise MH - Focus Groups MH - *Health Promotion/methods/organization & administration MH - *School Health Services/organization & administration MH - Schools MH - Spain MH - *Telemedicine MH - Randomized Controlled Trials as Topic PMC - PMC13281623 OTO - NOTNLM OT - Adolescents OT - EHealth OT - Health policies OT - Nutrition OT - Physical activity OT - Randomized controlled trial COIS- Declarations. Ethics approval and consent to participate: The study was approved by the IDIAP Jordi Gol clinical research ethics committee with registration code 24/099-P. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/03 05:27 MHDA- 2026/06/19 06:32 PMCR- 2026/05/02 CRDT- 2026/05/02 23:14 PHST- 2026/01/14 00:00 [received] PHST- 2026/04/23 00:00 [accepted] PHST- 2026/06/19 06:32 [medline] PHST- 2026/05/03 05:27 [pubmed] PHST- 2026/05/02 23:14 [entrez] PHST- 2026/05/02 00:00 [pmc-release] AID - 10.1186/s12889-026-27587-8 [pii] AID - 27587 [pii] AID - 10.1186/s12889-026-27587-8 [doi] PST - epublish SO - BMC Public Health. 2026 May 2;26(1):1922. doi: 10.1186/s12889-026-27587-8. PMID- 42068652 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 1879-1379 (Electronic) IS - 0022-3956 (Print) IS - 0022-3956 (Linking) VI - 199 DP - 2026 Aug TI - Urinary pesticide biomarker associations with depression and anxiety scores from adolescence into young adulthood in the ESPINA cohort. PG - 175-188 LID - S0022-3956(26)00234-7 [pii] LID - 10.1016/j.jpsychires.2026.04.023 [doi] AB - INTRODUCTION: Growing evidence suggests pesticide exposure can affect emotional well-being; limited research exists across adolescence and young adulthood. We examined cross-sectional and longitudinal associations of pesticide biomarkers with anxiety and depression scores. METHODS: We analyzed 646 participants from Ecuadorian agricultural communities: 510 in 2016 (ages 11-17y) and 485 in 2022 (17-24y). Twelve urinary insecticide metabolites were measured. Validated questionnaires assessed depression and anxiety. Generalized estimating equations (GEE) estimated associations for continuous scores and logit GEE calculated odds ratios (OR) of elevated symptoms, adjusting for demographic and anthropometric variables. RESULTS: In 2016, an interquartile range higher overall pesticides summed (beta = 1.01 95%CI:[0.48, 1.53]), organophosphates summed (beta = 0.99 [0.47, 1.51]), 3,5,6-trichloro-2-pyridinol (TCPy; beta = 0.97 [0.49, 1.45]), pyrethroids summed (beta = 0.69 [0.11, 1.27]) and 3-phenoxybenzoic acid (beta = 0.31 [0.01, 0.61]) were positively associated with depression. Detectable 5-hydroxy imidacloprid (OHIM) doubled elevated depression odds. In 2022, higher sulfoxaflor isomers were protective, but higher clothianidin increased elevated depression odds. Longitudinally, depression was positively associated with overall pesticides summed (beta = 0.06 [0.02, 0.11]), organophosphates summed (beta = 0.05 [0.001, 0.10]), TCPy (beta = 0.06 [0.02, 0.10]), pyrethroids summed and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (trans-DCCA; beta = 0.01 [0.003, 0.02]). For anxiety, in 2016 detectable trans-DCCA (OR = 2.52 [1.52, 4.16]) was associated with elevated symptoms. In 2022, higher clothianidin increased elevated anxiety odds (OR = 1.44 [1.07, 1.93]). Longitudinally, trans-DCCA (OR = 1.39 [1.03, 1.87]) and OHIM (OR = 1.44 [1.02, 2.04]) increased elevated anxiety odds. CONCLUSIONS: Organophosphates, pyrethroids, and neonicotinoids were generally linked to higher depression and anxiety, while sulfoximines and one organophosphate appeared protective. OHIM and trans-DCCA showed consistent adverse associations across years. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Chronister, Briana N C AU - Chronister BNC AD - Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, 92093, USA; School of Public Health, San Diego State University, San Diego, CA, 92182, USA. FAU - Hussari, Mohammed N AU - Hussari MN AD - School of Medicine, University of California San Diego (UCSD), La Jolla, CA, USA. FAU - Lopez-Paredes, Dolores AU - Lopez-Paredes D AD - Fundacion Cimas del Ecuador, Quito, Ecuador. FAU - Checkoway, Harvey AU - Checkoway H AD - Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, 92093, USA. FAU - Suarez-Torres, Jose AU - Suarez-Torres J AD - Fundacion Cimas del Ecuador, Quito, Ecuador. FAU - Gahagan, Sheila AU - Gahagan S AD - Department of Pediatrics, University of California, La Jolla, San Diego, CA, 92093, USA. FAU - Bradman, Asa AU - Bradman A AD - Department of Public Health, School of Social Sciences, Humanities, and Arts, University of California, Merced, CA, USA. FAU - Martinez, Danilo AU - Martinez D AD - Fundacion Cimas del Ecuador, Quito, Ecuador. FAU - Hong, Suzi AU - Hong S AD - Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, 92093, USA. FAU - Moore, Raeanne C AU - Moore RC AD - Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA. FAU - Suarez-Lopez, Jose R AU - Suarez-Lopez JR AD - Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, 92093, USA. Electronic address: jrsuarez@health.ucsd.edu. LA - eng GR - U2C ES026560/ES/NIEHS NIH HHS/United States GR - R21 ES026084/ES/NIEHS NIH HHS/United States GR - R01 ES025792/ES/NIEHS NIH HHS/United States GR - T32 MH122376/MH/NIMH NIH HHS/United States GR - R01 ES030378/ES/NIEHS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260423 PL - England TA - J Psychiatr Res JT - Journal of psychiatric research JID - 0376331 RN - 0 (Pesticides) RN - 0 (Biomarkers) RN - 0 (Organophosphates) RN - 0 (Pyridones) RN - 0 (Pyrethrins) RN - 6515-38-4 (3,5,6-trichloro-2-pyridinol) SB - IM UOF - medRxiv. 2025 Dec 12:2025.12.10.25341988. doi: 10.64898/2025.12.10.25341988. PMID: 41415499 MH - Humans MH - Male MH - Female MH - Adolescent MH - *Depression/epidemiology/chemically induced/urine MH - *Anxiety/epidemiology/chemically induced/urine MH - *Pesticides/urine MH - Longitudinal Studies MH - Young Adult MH - Ecuador/epidemiology MH - Biomarkers/urine MH - Child MH - Cross-Sectional Studies MH - Organophosphates/urine MH - Pyridones/urine MH - Pyrethrins/urine MH - Cohort Studies PMC - PMC13286626 MID - NIHMS2173723 COIS- Declaration of competing interest RCM is a co-founder, has equity interest, is a consultant and receives compensation from NeuroUX, a company that develops mobile cognitive tests. The terms of this arrangement have been reviewed and approved by UC San Diego in accordance with its conflict of interest policies. All other authors report having no conflicts of interest. EDAT- 2026/05/03 05:27 MHDA- 2026/05/24 04:38 PMCR- 2026/06/22 CRDT- 2026/05/02 18:02 PHST- 2025/12/10 00:00 [received] PHST- 2026/02/17 00:00 [revised] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/05/24 04:38 [medline] PHST- 2026/05/03 05:27 [pubmed] PHST- 2026/05/02 18:02 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - S0022-3956(26)00234-7 [pii] AID - 10.1016/j.jpsychires.2026.04.023 [doi] PST - ppublish SO - J Psychiatr Res. 2026 Aug;199:175-188. doi: 10.1016/j.jpsychires.2026.04.023. Epub 2026 Apr 23. PMID- 42068470 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260914 IS - 1559-0100 (Electronic) IS - 1355-008X (Print) IS - 1355-008X (Linking) VI - 91 IP - 1 DP - 2026 May 2 TI - Developmental stages and exercise timing in relation to fear of hypoglycemia and quality of life in type 1 diabetes. LID - 10.1007/s12020-026-04632-5 [doi] LID - 162 AB - PURPOSE: To examine associations between physical activity (PA) characteristics and psychosocial outcomes - quality of life (QoL) and fear of hypoglycemia (FH) - in children, adolescents, and young adults with type 1 diabetes (T1D). METHODS: In this cross-sectional study, 100 insulin pump-treated outpatients T1D completed 7-day PA logs capturing timing, type, intensity, and volume. QoL and FH were assessed using age-appropriate validated instruments. General linear models evaluated associations between PA characteristics and psychosocial outcomes, accounting for age group and, in sensitivity analyses, sex and HbA1c. RESULTS: In pooled analyses (N = 82 complete cases), age group was significantly associated with both QoL (p = 0.037) and FH (p < 0.001), with a large effect size observed for FH. In sensitivity analyses adjusting for sex and HbA1c, the age-group effect on FH remained robust, whereas associations with QoL were attenuated. Exercise timing was associated with FH (p = 0.047), with higher adjusted FH scores observed among individuals reporting evening exercise. However, pairwise comparisons were not significant after correction. No significant AgeGroupxTiming interactions were detected. Preferred exercise type and intensity were not independently associated with psychosocial outcomes. In sensitivity analyses adjusted for sex and HbA1c (N = 62), the age-group effect on FH remained robust, whereas timing showed borderline significance. CONCLUSION: Developmental stage appears to be a major determinant of fear of hypoglycemia in youths with T1D. Exercise timing may contribute modestly to perceived hypoglycemia risk, particularly for evening activity, although findings were attenuated after adjustment. These cross-sectional associations highlight the importance of developmentally tailored exercise counselling, while longitudinal studies are needed to clarify directionality. CI - (c) 2026. The Author(s). FAU - Codella, Roberto AU - Codella R AD - Department of Endocrinology, Nutrition and Metabolic Diseases, IRCCS MultiMedica, Milan, 20138, Italy. roberto.codella@unimi.it. AD - Department of Biomedical Sciences for Health, Universita degli Studi di Milano, Milan, 20133, Italy. roberto.codella@unimi.it. FAU - Bisio, Ambra AU - Bisio A AD - Centro Polifunzionale di Scienze Motorie, University of Genoa, Genoa, 16132, Italy. AD - Department of Experimental Medicine, Section of Human Physiology, University of Genoa, Genoa, 16132, Italy. FAU - Gotti, Daniel AU - Gotti D AD - Department of Biomedical Sciences for Health, Universita degli Studi di Milano, Milan, 20133, Italy. FAU - Bassi, Marta AU - Bassi M AD - Pediatric Clinic, IRCCS Istituto Giannina Gaslini, University of Genoa, Genoa, Italy. FAU - Minuto, Nicola AU - Minuto N AD - Pediatric Clinic, IRCCS Istituto Giannina Gaslini, University of Genoa, Genoa, Italy. FAU - Ruggeri, Piero AU - Ruggeri P AD - Centro Polifunzionale di Scienze Motorie, University of Genoa, Genoa, 16132, Italy. AD - Department of Experimental Medicine, Section of Human Physiology, University of Genoa, Genoa, 16132, Italy. FAU - Luzi, Livio AU - Luzi L AD - Department of Endocrinology, Nutrition and Metabolic Diseases, IRCCS MultiMedica, Milan, 20138, Italy. AD - Department of Biomedical Sciences for Health, Universita degli Studi di Milano, Milan, 20133, Italy. FAU - Maggi, Davide AU - Maggi D AD - IRCCS San Martino, University of Genoa, Genoa, Italy. FAU - Faelli, Emanuela AU - Faelli E AD - Centro Polifunzionale di Scienze Motorie, University of Genoa, Genoa, 16132, Italy. AD - Department of Experimental Medicine, Section of Human Physiology, University of Genoa, Genoa, 16132, Italy. LA - eng PT - Journal Article DEP - 20260502 PL - United States TA - Endocrine JT - Endocrine JID - 9434444 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/psychology/drug therapy/blood MH - *Hypoglycemia/psychology MH - *Quality of Life/psychology MH - Female MH - *Fear/psychology MH - Male MH - Adolescent MH - Cross-Sectional Studies MH - *Exercise/psychology/physiology MH - Child MH - Young Adult MH - Adult PMC - PMC13135517 OTO - NOTNLM OT - Type 1 diabetes OT - exercise timing OT - fear of hypoglycemia OT - pediatric endocrinology OT - physical activity OT - quality of life COIS- Declarations. Consent to participate: Written informed consent was obtained from all participants or their legal guardians. Study approval: This study protocol was reviewed and approved by the Ethics Committee of the University of Genoa, Italy, approval number 23/2023. Conflict of interests: The authors declare no competing interests. EDAT- 2026/05/03 05:22 MHDA- 2026/05/03 05:23 PMCR- 2026/05/02 CRDT- 2026/05/02 11:07 PHST- 2026/01/09 00:00 [received] PHST- 2026/03/28 00:00 [accepted] PHST- 2026/05/03 05:23 [medline] PHST- 2026/05/03 05:22 [pubmed] PHST- 2026/05/02 11:07 [entrez] PHST- 2026/05/02 00:00 [pmc-release] AID - 10.1007/s12020-026-04632-5 [pii] AID - 4632 [pii] AID - 10.1007/s12020-026-04632-5 [doi] PST - epublish SO - Endocrine. 2026 May 2;91(1):162. doi: 10.1007/s12020-026-04632-5. PMID- 42068456 OWN - NLM STAT- Publisher LR - 20260502 IS - 1573-2606 (Electronic) IS - 1389-9155 (Linking) DP - 2026 May 2 TI - Harnessing food cue evoked neuroimaging towards treatment optimisation for obesity and binge eating disorder. LID - 10.1007/s11154-026-10045-6 [doi] AB - Obesity and binge eating disorder (BED) are global health concerns that share overlapping neural mechanisms. These include alterations in the brain's reward and control systems leading to heightened sensitivity to food cues and impaired self-regulation, which underpin overeating. Identifying neuroimaging-based biomarkers that index these mechanisms could advance individualised treatments. This scoping review examined evidence on fMRI food cue reactivity as a potential approach for developing predictive and response biomarkers relevant to the treatment of obesity and BED. A systematic search of MEDLINE, Scopus, PsycINFO, and Embase (to July 2025) identified 57 eligible studies incorporating fMRI cue reactivity measures in the context of pharmacological, surgical, psychological, and lifestyle interventions. Of these, 7 reported predictive outcomes only (6 for adults with obesity and 1 for children and adolescents with obesity), 41 reported response outcomes only (36 for adults with obesity, 3 for children and adolescents with obesity and 2 for adults with binge eating), and 9 reported both predictive and response outcomes (8 for adults with obesity and 1 for adults with binge eating). Across paradigms and intervention modalities, there was consistent involvement of reward (striatum, insula, orbitofrontal and ventromedial prefrontal cortex) and cognitive control regions (dorsolateral and dorsomedial prefrontal cortex) as response outcomes from successful treatment. Reductions in reward-system reactivity following interventions were consistently associated with improved clinical outcomes, supporting the potential of fMRI food cue reactivity as a candidate biomarker of treatment response. However, this finding is highly skewed towards obesity, given the limited number of studies that report results for BED (3 studies). Furthermore, consistent evidence for reliable predictive biomarkers was also limited, likely due to methodological variability and small sample sizes. Overall, this review supports the potential of response outcomes from fMRI food cue reactivity as an indicator of treatment efficacy in obesity and highlights the limited evidence in BED. We also emphasise the need for further standardisation of paradigms and biomarker validation efforts. CI - (c) 2026. The Author(s). FAU - Flanagan, Kayla AU - Flanagan K AUID- ORCID: 0009-0005-2971-5397 AD - Turner Institute for Brain and Mental Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia. FAU - Pacheco, Luiza Bonfim AU - Pacheco LB AUID- ORCID: 0009-0002-9481-8198 AD - Turner Institute for Brain and Mental Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia. FAU - Gao, Mengxia AU - Gao M AUID- ORCID: 0000-0003-3393-5497 AD - Turner Institute for Brain and Mental Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia. AD - School of Humanities and Social Science, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Guangdong, 518172, People's Republic of China. FAU - Verdejo-Garcia, Antonio AU - Verdejo-Garcia A AUID- ORCID: 0000-0001-8874-9339 AD - Turner Institute for Brain and Mental Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia. Antonio.Verdejo@monash.edu. LA - eng PT - Journal Article PT - Review DEP - 20260502 PL - Germany TA - Rev Endocr Metab Disord JT - Reviews in endocrine & metabolic disorders JID - 100940588 SB - IM OTO - NOTNLM OT - Binge eating OT - Obesity OT - Predictive biomarkers OT - Response biomarkers OT - fMRI food cue reactivity COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/05/03 05:24 MHDA- 2026/05/03 05:24 CRDT- 2026/05/02 11:06 PHST- 2025/10/22 00:00 [received] PHST- 2026/04/22 00:00 [accepted] PHST- 2026/05/03 05:24 [medline] PHST- 2026/05/03 05:24 [pubmed] PHST- 2026/05/02 11:06 [entrez] AID - 10.1007/s11154-026-10045-6 [pii] AID - 10.1007/s11154-026-10045-6 [doi] PST - aheadofprint SO - Rev Endocr Metab Disord. 2026 May 2. doi: 10.1007/s11154-026-10045-6. PMID- 42068285 OWN - NLM STAT- Publisher LR - 20261022 IS - 2047-945X (Electronic) IS - 0260-1060 (Print) IS - 0260-1060 (Linking) DP - 2026 May 2 TI - Nutrition security, diet quality, and food assistance program use among food insecure households with children: A cross-sectional analysis. PG - 2601060261445338 LID - 10.1177/02601060261445338 [doi] AB - BackgroundWhile food insecurity (FI) assesses household access to sufficient food, increasing attention is being paid to nutrition security (NS), the ability to obtain health-promoting foods.AimThis cross-sectional analysis examined differences in sociodemographics, diet quality, and health status between food insecure families with low versus high NS and assessed if FI and NS severity was associated with food assistance program use.MethodsData were obtained from the 2023 Massachusetts Statewide Food Access Survey of >3000 adults. FI was assessed using the United States Department of Agriculture 18-item Household Food Security Module, NS via a validated four-item scale, and diet quality via the Prime Diet Quality Score (PDQS). FI and NS were analyzed as binary and continuous variables. Inferential statistics assessed group differences. Logistic regression assessed associations between the severity of FI and NS and food assistance program use.SummaryHouseholds with FI, >/=1 child ( 18 years old) presented lower scores (unstandardized beta coefficient [B] = -1.59; p = 0.006), as did those enrolled in non-health science degrees (B = -1.47; p = 0.005), single students (B =-1.40; p = 0.013), and those with a mental disorder (B = -2.79; p = 0.001). Heterosexual students scored higher than non-heterosexual peers (B = 2.49; p = 0.007), and students with normal weight showed better results than underweight participants (B = 2.08; p = 0.020). Domain-specific analyses revealed that males scored higher in physical activity, sleep, and social support, whereas females performed better in stress management. Students residing outside university accommodation generally achieved higher domain scores. CONCLUSIONS: These exploratory findings suggest that lifestyle, as measured by the U-SMILE, is associated with several sociodemographic and health-related characteristics in Spanish university students. Lower scores were associated with older age, enrolment in non-health science degrees, underweight status, non-heterosexual orientation, single marital status, and the presence of a diagnosed mental disorder. Sex, BMI status, accommodation, and employment status were associated with specific lifestyle domains. CI - (c) 2026. The Author(s). FAU - Mendoza-Munoz, Maria AU - Mendoza-Munoz M AD - Department of Education and Sport, Universidad Loyola Andalucia, Sevilla, Spain. FAU - Manzano-Carrasco, Samuel AU - Manzano-Carrasco S AD - Department of Education and Sport, Universidad Loyola Andalucia, Sevilla, Spain. FAU - Montenegro-Espinosa, Jose Adrian AU - Montenegro-Espinosa JA AD - Universidad Autonoma del Paraguay, Asuncion, Paraguay. FAU - Quiroz-Cardenas, Fiorella AU - Quiroz-Cardenas F AD - Universidad Politecnica y Artistica del Paraguay, Asuncion, Paraguay. FAU - Yanez-Sepulveda, Rodrigo AU - Yanez-Sepulveda R AD - Faculty Education and Social Sciences, Universidad Andres Bello, Vina del Mar, Chile. AD - Department of Sport Sciences, Fit Generation Research Institute, Andorra la Vella, Andorra. FAU - Olivares-Arancibia, Jorge AU - Olivares-Arancibia J AD - AFySE Group, Research in Physical Activity and School Health, School of Physical Education, Faculty of Education, Universidad de las Americas, Santiago, Chile. FAU - Yon, Dong Keon AU - Yon DK AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Precision Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. FAU - Schuch, Felipe Barreto AU - Schuch FB AD - Psychiatry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. AD - Department of Sports Methods and Techniques, Federal University of Santa Maria, Santa Maria, RS, Brazil. AD - Faculty of Health Sciences, Universidad Autonoma de Chile, Providencia, Chile. FAU - Galan-Lopez, Pablo AU - Galan-Lopez P AD - Department of Education and Sport, Universidad Loyola Andalucia, Sevilla, Spain. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AD - School of Medicine, Universidad Espiritu Santo, Samborondon, Ecuador. josefranciscolopezgil@gmail.com. AD - Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno, Chile. josefranciscolopezgil@gmail.com. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260501 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - Spain/epidemiology MH - Universities MH - Male MH - Cross-Sectional Studies MH - *Students/statistics & numerical data/psychology MH - *Life Style MH - Young Adult MH - Adolescent MH - Surveys and Questionnaires MH - Adult MH - *Health Behavior MH - Socioeconomic Factors PMC - PMC13285052 OTO - NOTNLM OT - College students OT - Lifestyle behaviors OT - Nutrition OT - Physical activity OT - Sleep OT - Spain COIS- Declarations. Ethics approval and consent to participate: The study protocol received ethical approval from the Research Ethics Committee of Universidad Loyola Andalucia (Approval ID: 240605/CE24544). The participants provided written consent. All methods procedures were carried out in accordance with Declaration of Helsinki. All participants were informed about the purpose of the study, assured of confidentiality, and provided written consent prior to participation. Participation was voluntary, and respondents could withdraw at any time without consequence. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/02 00:33 MHDA- 2026/06/22 13:44 PMCR- 2026/05/01 CRDT- 2026/05/01 23:26 PHST- 2026/02/23 00:00 [received] PHST- 2026/04/20 00:00 [accepted] PHST- 2026/06/22 13:44 [medline] PHST- 2026/05/02 00:33 [pubmed] PHST- 2026/05/01 23:26 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - 10.1186/s12889-026-27518-7 [pii] AID - 27518 [pii] AID - 10.1186/s12889-026-27518-7 [doi] PST - epublish SO - BMC Public Health. 2026 May 1;26(1):1937. doi: 10.1186/s12889-026-27518-7. PMID- 42067530 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 2052-4463 (Electronic) IS - 2052-4463 (Linking) VI - 13 IP - 1 DP - 2026 May 1 TI - EED-Astig: A Multimodal Dataset for Pediatric Astigmatism Severity Prediction. LID - 10.1038/s41597-026-07330-z [doi] LID - 993 AB - Astigmatism is a prevalent refractive error in preschool children and a leading cause of preventable early visual impairment. Conventional screening methods are often unsuitable for young children due to high costs, specialized equipment, and the need for active cooperation. To address these challenges, we present EED-Astig, a multimodal pediatric dataset for artificial intelligence based astigmatism severity prediction. The dataset comprises periocular images from 640 children aged 3-6 years, acquired with smartphones under standardized conditions, with expert-verified annotations of corneal masks and anatomical landmarks. From these, we derive six clinically relevant structural parameters, including corneal exposure ratio and eyelash orientation, that are physiologically linked to astigmatism. In addition, behavioral and demographic metadata (e.g., screen time, birth history) provide complementary predictors for supervised learning. A semi-automated annotation pipeline based on the Segment Anything Model (SAM) ensures labeling consistency and quality. Technical validation demonstrates robust performance in keypoint detection and image segmentation, supporting the development of interpretable and scalable AI tools for pediatric eye health, particularly in low-resource settings. CI - (c) 2026. The Author(s). FAU - Liu, Haihua AU - Liu H AD - Department of Ophthalmology Center, Peking University First Hospital, Beijing, 100034, China. FAU - Li, Shengyang AU - Li S AD - Technology and Engineering Center for Space Utilization, Chinese Academy of Sciences, Beijing, 100094, China. shyli@csu.ac.cn. AD - University of Chinese Academy of Sciences, Beijing, 100049, China. shyli@csu.ac.cn. FAU - Lv, Yixuan AU - Lv Y AUID- ORCID: 0000-0002-9007-3822 AD - Technology and Engineering Center for Space Utilization, Chinese Academy of Sciences, Beijing, 100094, China. lvyixuan@csu.ac.cn. FAU - Liu, Rongjun AU - Liu R AD - Department of Ophthalmology Center, Peking University First Hospital, Beijing, 100034, China. FAU - Hou, Xinlin AU - Hou X AD - Department of Ophthalmology Center, Peking University First Hospital, Beijing, 100034, China. FAU - Chen, Furui AU - Chen F AD - Technology and Engineering Center for Space Utilization, Chinese Academy of Sciences, Beijing, 100094, China. AD - University of Chinese Academy of Sciences, Beijing, 100049, China. FAU - Liu, Yuxuan AU - Liu Y AD - Technology and Engineering Center for Space Utilization, Chinese Academy of Sciences, Beijing, 100094, China. AD - University of Chinese Academy of Sciences, Beijing, 100049, China. FAU - You, Jianing AU - You J AD - Technology and Engineering Center for Space Utilization, Chinese Academy of Sciences, Beijing, 100094, China. AD - University of Chinese Academy of Sciences, Beijing, 100049, China. FAU - Wang, Han AU - Wang H AD - Technology and Engineering Center for Space Utilization, Chinese Academy of Sciences, Beijing, 100094, China. AD - University of Chinese Academy of Sciences, Beijing, 100049, China. FAU - Liu, Silei AU - Liu S AD - Technology and Engineering Center for Space Utilization, Chinese Academy of Sciences, Beijing, 100094, China. AD - University of Chinese Academy of Sciences, Beijing, 100049, China. LA - eng PT - Dataset PT - Journal Article DEP - 20260501 PL - England TA - Sci Data JT - Scientific data JID - 101640192 SB - IM MH - Humans MH - *Astigmatism/diagnosis MH - Child, Preschool MH - Child MH - Artificial Intelligence PMC - PMC13338130 COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/05/02 00:33 MHDA- 2026/07/07 12:34 PMCR- 2026/05/01 CRDT- 2026/05/01 23:14 PHST- 2025/10/01 00:00 [received] PHST- 2026/04/22 00:00 [accepted] PHST- 2026/07/07 12:34 [medline] PHST- 2026/05/02 00:33 [pubmed] PHST- 2026/05/01 23:14 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - 10.1038/s41597-026-07330-z [pii] AID - 7330 [pii] AID - 10.1038/s41597-026-07330-z [doi] PST - epublish SO - Sci Data. 2026 May 1;13(1):993. doi: 10.1038/s41597-026-07330-z. PMID- 42066635 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 148 DP - 2026 Aug TI - Specific Nutrition Evaluation for Advanced Chronic Liver Disease: Validation through psychometrics analysis. PG - 113211 LID - S0899-9007(26)00119-X [pii] LID - 10.1016/j.nut.2026.113211 [doi] AB - OBJECTIVES: Validated instruments specifically designed to assess the nutritional status of individuals with chronic liver disease (CLD) are scarce. The purpose of this study was to evaluate the psychometric properties of the Specific Nutrition Evaluation for Advanced Chronic Liver Disease (SNE-ACLD) instrument and establish cut-off points for the nutritional assessment of individuals with CLD. METHODS: Hospitalized individuals with CLD were evaluated by SNE-ACLD and different nutritional assessment tools. Initial evidence of structural construct validity was assessed using principal component analysis; reliability using Cronbach's alpha; cut-off points were determined using cluster analysis. Criterion validity, in which the appendicular muscle mass index was adopted as a reference for concurrent validity using ROC curve; and Cox regression to assess the one-year mortality risk for predictive validity. RESULTS: Two hundred participants were evaluated, of which 75.0% were male, 50.5% were elderly, and 80.8% were classified as Child-Pugh B or C. Principal component analysis demonstrated that SNE-ACLD has four components that explain 69.9% of the total variance of the construct. Cronbach's alpha of 0.70 indicated a good interrelationship between the items. The established cut-off points classified the participants into four groups: without malnutrition, mild, moderate, or severe malnutrition. The SNE-ACLD showed concurrent validity with an AUC of 0.714 and predictive validity, with severely malnourished participants presenting one-year mortality risk almost five times higher (HR = 4.98; 95% CI: 2.42-10.2) than those without severe malnutrition. CONCLUSIONS: SNE-ACLD effectively addresses the domains of the malnutrition construct in this public, presenting evidence of both internal and external validity. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Arruda, Monalisa Reis AU - Arruda MR AD - Graduate Program in Food, Nutrition and Health, Department of Nutrition, School of Nutrition, Federal University of Bahia, Salvador, Bahia, Brazil. Electronic address: monalisa.arruda@ufba.br. FAU - Cunha, Carla de Magalhaes AU - Cunha CM AD - Graduate Program in Food, Nutrition and Health, Department of Nutrition, School of Nutrition, Federal University of Bahia, Salvador, Bahia, Brazil. FAU - Batista, Ana Clara Vital AU - Batista ACV AD - Graduate Program in Food, Nutrition and Health, Department of Nutrition, School of Nutrition, Federal University of Bahia, Salvador, Bahia, Brazil. FAU - Boulhosa, Ramona Souza da Silva Baqueiro AU - Boulhosa RSDSB AD - Graduate Program in Food, Nutrition and Health, Department of Nutrition, School of Nutrition, Federal University of Bahia, Salvador, Bahia, Brazil. FAU - Garcez, Lais Spindola AU - Garcez LS AD - Graduate Program in Food, Nutrition and Health, Department of Nutrition, School of Nutrition, Federal University of Bahia, Salvador, Bahia, Brazil. FAU - Lyra, Andre Castro AU - Lyra AC AD - Graduate Program in Medicine and Health, Department of Medicine, Faculty of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil. FAU - Romeiro, Fernando Gomes AU - Romeiro FG AD - Graduate Program in Pathophysiology in Internal Medicine, Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University, Botucatu, Sao Paulo, Brazil. FAU - Pereira, Ketlin Gianini AU - Pereira KG AD - Graduate Program in Pathophysiology in Internal Medicine, Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University, Botucatu, Sao Paulo, Brazil. FAU - Cavalcante, Lourianne Nascimento AU - Cavalcante LN AD - Graduate Program in Medicine and Health, Department of Medicine, Faculty of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil. FAU - de Jesus, Rosangela Passos AU - de Jesus RP AD - Graduate Program in Food, Nutrition and Health, Department of Nutrition, School of Nutrition, Federal University of Bahia, Salvador, Bahia, Brazil. FAU - de Oliveira, Lucivalda Pereira Magalhaes AU - de Oliveira LPM AD - Graduate Program in Food, Nutrition and Health, Department of Nutrition, School of Nutrition, Federal University of Bahia, Salvador, Bahia, Brazil. LA - eng PT - Journal Article PT - Validation Study DEP - 20260317 PL - United States TA - Nutrition JT - Nutrition (Burbank, Los Angeles County, Calif.) JID - 8802712 SB - IM MH - Humans MH - Male MH - *Nutrition Assessment MH - Female MH - Reproducibility of Results MH - *Psychometrics MH - *Nutritional Status MH - *Liver Diseases/complications MH - Middle Aged MH - Chronic Disease MH - Aged MH - *Malnutrition/diagnosis MH - Principal Component Analysis MH - Adult MH - ROC Curve OTO - NOTNLM OT - Chronic liver disease OT - Instruments OT - Malnutrition OT - Nutritional assessment OT - Psychometrics COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/02 00:33 MHDA- 2026/05/17 06:29 CRDT- 2026/05/01 18:07 PHST- 2025/11/28 00:00 [received] PHST- 2026/02/03 00:00 [revised] PHST- 2026/03/15 00:00 [accepted] PHST- 2026/05/17 06:29 [medline] PHST- 2026/05/02 00:33 [pubmed] PHST- 2026/05/01 18:07 [entrez] AID - S0899-9007(26)00119-X [pii] AID - 10.1016/j.nut.2026.113211 [doi] PST - ppublish SO - Nutrition. 2026 Aug;148:113211. doi: 10.1016/j.nut.2026.113211. Epub 2026 Mar 17. PMID- 42065159 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 18 DP - 2026 May 1 TI - Vitamin D concentrations and headache risk in children and adolescents aged 6 to 19 years: The mediating role of body mass index. PG - e48477 LID - 10.1097/MD.0000000000048477 [doi] LID - e48477 AB - Emerging evidence suggests vitamin D deficiency might be linked to increased headache risk, though consistent conclusions are lacking due to population and methodological heterogeneity. In addition, childhood and adolescent obesity may influence headache development through metabolic and inflammatory pathways, but the specific role of body mass index (BMI) in the relationship between vitamin D and headache is currently unclear. Therefore, this study used National Health and Nutrition Examination Survey (NHANES) large-scale population-based data to investigate the association between vitamin D levels and headache risk in children and adolescents aged 6 to 19 years and to analyze the possible mediating effect of BMI on this relationship. The aim of this study was to explore the complex association between vitamin D levels and headache. We analyzed 2 cycles of the NHANES dataset, which included a total of 7066 children and adolescents aged 6 to 19 years. Multivariate linear regression models, subgroup analyses and smoothed curve fitting were used to investigate the associations between vitamin D levels and headache, and the potential mediating role of BMI was explored. The results of the present study revealed a evident negative correlation between vitamin D levels and headache risk in children and adolescents, a finding that was further supported by smoothed curve fitting. Notably, this negative correlation was stronger in the female and adolescent groups. The results of the mediation analysis revealed that BMI had a evident mediating effect, with a mediation ratio of 20.94%. This study found that lower vitamin D levels were associated with a higher likelihood of headache in children and adolescents, and that BMI may play a partial mediating role. This finding provides new strategies for the prevention and treatment of headache in children and adolescents. More prospective studies are necessary to further validate this association and its underlying mechanisms. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Zhang, Min AU - Zhang M AUID- ORCID: 0009-0009-3102-755 AD - Department of Otolaryngology, Kunming Medical University Affiliated Children's Hospital (Kunming Children's Hospital), Kunming, Yunnan Province, China. FAU - Xie, Juan AU - Xie J AD - Yunnan Institute of Pediatrics, Yunnan Key Laboratory of Children's Major Disease Research, Yunnan Province Clinical Research Center for Children's Health and Disease, Kunming Medical University Affiliated Children's Hospital (Kunming Children's Hospital), Kunming, Yunnan Province, China. FAU - Guo, Cheng AU - Guo C AD - Comprehensive Pediatrics, Kunming Medical University Affiliated Children's Hospital (Kunming Children's Hospital), Kunming , Yunnan Province, China. FAU - Zhang, Tiesong AU - Zhang T AD - Department of Otolaryngology, Kunming Medical University Affiliated Children's Hospital (Kunming Children's Hospital), Kunming, Yunnan Province, China. FAU - Liu, Kai AU - Liu K AUID- ORCID: 0000-0002-3374-3375 AD - Comprehensive Pediatrics, Kunming Medical University Affiliated Children's Hospital (Kunming Children's Hospital), Kunming , Yunnan Province, China. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R RN - 1406-16-2 (Vitamin D) SB - IM MH - Humans MH - Adolescent MH - Child MH - Female MH - *Vitamin D/blood MH - *Body Mass Index MH - Male MH - *Headache/epidemiology/etiology/blood MH - *Vitamin D Deficiency/complications/epidemiology/blood MH - Nutrition Surveys MH - Young Adult MH - Risk Factors PMC - PMC13138427 OTO - NOTNLM OT - BMI OT - cross-sectional studies, headache, mediation analyses OT - vitamin D COIS- The authors have no funding and conflicts of interest to disclose. EDAT- 2026/05/01 06:34 MHDA- 2026/05/01 12:36 PMCR- 2026/05/01 CRDT- 2026/05/01 05:33 PHST- 2025/09/04 00:00 [received] PHST- 2026/01/04 00:00 [accepted] PHST- 2026/05/01 12:36 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 05:33 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - 00005792-202605010-00016 [pii] AID - MD-D-25-10671 [pii] AID - 10.1097/MD.0000000000048477 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 May 1;105(18):e48477. doi: 10.1097/MD.0000000000048477. PMID- 42065146 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260819 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 18 DP - 2026 May 1 TI - Impact of competitive anxiety on mood, sleep, and physical activity levels in young Tunisian karate athletes: A multidimensional prospective observational study. PG - e48435 LID - 10.1097/MD.0000000000048435 [doi] LID - e48435 AB - This study examined the impact of competition-related anxiety on psychological and behavioral parameters of Tunisian karate athletes. A total of 176 young Tunisian karate athletes (aged 16-25 years) with at least 1 year of training and competitive experience voluntarily participated in this study. Validated instruments were administered 1 week before and on the day of the competition, including the State-Trait Anxiety Inventory, the Pittsburgh Sleep Quality Index, the Brunel Mood Scale, and the International Physical Activity Questionnaire. Paired Wilcoxon signed-rank tests were used to compare changes over time, and multiple linear regression models were used to identify predictors of state and trait anxiety. Anxiety, mood, sleep, and physical activity changed from 1 week before to competition day (all P < .001). One week before, state anxiety was higher with tension (beta = 1.22, P < .001), fatigue (beta = 1.49, P < .001), and confusion (beta = 1.14, P < .001); trait anxiety was higher with anger (beta = 1.15, P < .001), depression (beta = 1.38, P < .001), and fatigue (beta = 0.42, P = .004), and lower with confusion (beta = -0.36, P = .009). State anxiety was positively associated with sleep disturbances (beta = 5.94, P < .001); trait anxiety with poorer subjective sleep quality (beta = 2.87, P < .001) and longer sleep latency (beta = 0.26, P < .001). Vigorous MET-minutes predicted lower state anxiety (beta = -0.009, P = .02) and walking predicted lower trait anxiety (beta = -0.007, P = .007). State anxiety increased with confusion (beta = 1.47, P < .001) and decreased with vigor (beta = -0.94, P = .003); trait anxiety increased with depression (beta = 1.53, P < .001) and fatigue (beta = 1.34, P < .001). Daytime dysfunction predicted higher state anxiety (beta = 8.91, P < .001) and sleep latency predicted higher trait anxiety (beta = 0.10, P = .031). Moderate MET-minutes predicted higher state anxiety (beta = 0.008, P = .02). Increases in state anxiety aligned with higher tension (beta = 0.93, P < .001), fatigue (beta = 0.61, P = .004), and confusion (beta = 1.89, P < .001), and decreases with depression (beta = -0.54, P = .02). Increases in trait anxiety were driven by depression (beta = 1.67, P < .001) and fatigue (beta = 1.06, P < .001). Greater daytime dysfunction predicted increases in state anxiety (beta = 9.28, P < .001), whereas longer sleep latency (beta = 0.19, P < .001) and shorter sleep duration (beta = -3.18, P < .001) predicted increases in trait anxiety; activity changes were not significant. Competition anxiety in young karate athletes is chiefly associated with mood disturbances and sleep parameters; implementing mood-regulation and sleep-focused strategies may reduce anxiety in youth combat sports. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Belgacem, Ahlem AU - Belgacem A AD - High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, Tunisia. AD - Research Laboratory: Education, Motricite, Sport et Sante (EM2S, LR19JS01), High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, Tunisia. FAU - Salem, Atef AU - Salem A AUID- ORCID: 0000-0003-0680-6841 AD - Department of Training and Movement Science, Institute of Sport Science, Johannes Gutenberg-University Mainz, Mainz, Germany. FAU - Yildiz, Mevlut AU - Yildiz M AD - Coaching Sciences, Faculty of Sports Sciences, Mugla Sitki Kocman University, Mugla, Turkiye. FAU - Ceylan, Halil Ibrahim AU - Ceylan HI AD - Physical Education and Sports Teaching Department, Faculty of Sports Sciences, Ataturk University, Erzurum, Turkiye. FAU - Ben Hassen, Said AU - Ben Hassen S AD - Tunisian Research Laboratory Sports Performance Optimization, National Center of Medicine and Science in Sports (CNMSS), Tunis, Tunisia. FAU - Negra, Yassine AU - Negra Y AD - Higher Institute of Sport and Physical Education of Ksar Said, University of Manouba, Tunis, Tunisia. FAU - Muntean, Raul Ioan AU - Muntean RI AUID- ORCID: 0000-0003-4615-6687 AD - Department of Physical Education and Sport, Faculty of Law and Social Sciences, University "1 Decembrie 1918" of Alba Iulia, Alba Iulia, Romania. FAU - Jarraya, Mohamed AU - Jarraya M AD - High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, Tunisia. AD - Research Laboratory: Education, Motricite, Sport et Sante (EM2S, LR19JS01), High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, Tunisia. LA - eng PT - Journal Article PT - Observational Study PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - *Anxiety/psychology/epidemiology MH - Male MH - Tunisia MH - *Martial Arts/psychology MH - *Affect/physiology MH - Adolescent MH - *Athletes/psychology MH - Prospective Studies MH - Young Adult MH - *Sleep/physiology MH - Female MH - Adult MH - Surveys and Questionnaires MH - *Exercise/psychology MH - Fatigue MH - Depression PMC - PMC13138430 OTO - NOTNLM OT - competitive anxiety OT - karate OT - mood disturbance OT - physical activity OT - regression analysis OT - sleep quality OT - youth athletes COIS- The authors have no funding and conflicts of interest to disclose. EDAT- 2026/05/01 06:34 MHDA- 2026/05/01 12:36 PMCR- 2026/05/01 CRDT- 2026/05/01 05:33 PHST- 2025/10/06 00:00 [received] PHST- 2026/04/02 00:00 [accepted] PHST- 2026/05/01 12:36 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 05:33 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - 00005792-202605010-00003 [pii] AID - MD-D-25-13333 [pii] AID - 10.1097/MD.0000000000048435 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 May 1;105(18):e48435. doi: 10.1097/MD.0000000000048435. PMID- 42065000 OWN - NLM STAT- MEDLINE DCOM- 20260515 LR - 20260813 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 15 DP - 2026 TI - Anthropometry, energy, and nutrient intake of orphanage children (2-5 years) in eastern and western district of Kogi state. PG - e28 LID - 10.1017/jns.2026.10091 [doi] LID - e28 AB - Malnutrition in children remains a major global public health concern, especially in sub-Saharan Africa. A cross-sectional study was conducted among 120 children, with a sub-sample of 23 children selected for a 3-day weighed food intake assessment. Data were collected using a validated questionnaire, anthropometric measurements, and dietary intake records. Analysis was performed using SPSS version 21 and results were presented as means, frequencies, and percentages. The daily energy intake of children aged 4 and 5 years was below the recommended levels (74.1% and 64.3%, respectively). However, children aged 2 and 3 years had adequate energy intakes, exceeding the recommendations (102.4% and 111.5%). Iron intake across all age groups was below the recommended dietary intake. Intake of B-complex vitamins (B(1), B(2), B(3)) among 2-, 3-, and 5-year-olds exceeded recommended levels. Calcium intake was consistently low across all age groups (2 years: 37.5%, 3 years: 44.6%, 4 years: 23.5%, 5 years: 24.7%), this is due to low consumption of protein food sources and vegetables rich in calcium. Key factors influencing low nutritional status included inadequate consumption of high protein food sources, overreliance on carbohydrate food (cassava flour), poor consumption of fruits and vegetables, and inability to access food due to sickness. The study highlights suboptimal intake of energy and essential micronutrients among orphanage children, particularly older age groups. Nutrition education, improved feeding practices, and increased dietary diversity are essential to improve the nutritional status of children in orphanages. CI - (c) The Author(s) 2026. FAU - Nweze, Ifedilichukwu Emilia AU - Nweze IE AUID- ORCID: 0009-0005-8121-2092 AD - Natural Science Unit, School of General Studies, University of Nigeria, Nsukka, Enugu 410101, Nigeria. ROR: https://ror.org/01sn1yx84 FAU - Ibeanu, Vivienne N AU - Ibeanu VN AD - Department of Nutrition and Dietetics, Faculty of Agriculture, University of Nigeria, Nsukka, Enugu 410101, Nigeria. FAU - Onyia, Uchechukwu AU - Onyia U AD - Department of Home Science and Management, Faculty of Agriculture, University of Nigeria, Nsukka, Enugu, 410101, Nigeria. FAU - Tochukwu Onyemaechi, Ijeoma AU - Tochukwu Onyemaechi I AD - Department of Human Nutrition and Dietetics, Enugu State University of Science and Technology, Enugu, Nigeria. LA - eng PT - Journal Article DEP - 20260427 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 RN - 0 (Dietary Carbohydrates) RN - 0 (Dietary Proteins) RN - 0 (Vitamins) RN - 0 (Trace Elements) SB - IM MH - Humans MH - Child Nutrition Disorders/etiology/prevention & control MH - Child, Preschool MH - Nigeria MH - *Orphanages MH - Anthropometry MH - *Energy Intake MH - *Eating MH - Male MH - Female MH - Socioeconomic Factors MH - Diet MH - Dietary Carbohydrates/administration & dosage MH - Dietary Proteins/administration & dosage MH - Vegetables MH - Vitamins/administration & dosage MH - Trace Elements/administration & dosage MH - Schools PMC - PMC13126059 OTO - NOTNLM OT - Anthropometry OT - Diversity OT - Energy intake OT - Intake OT - Malnutrition OT - Nutrient OT - Nutrient intake OT - Orphanage children OT - Weight OT - food COIS- The authors declare none. EDAT- 2026/05/01 06:34 MHDA- 2026/05/01 06:35 PMCR- 2026/04/27 CRDT- 2026/05/01 05:20 PHST- 2025/06/19 00:00 [received] PHST- 2025/11/28 00:00 [revised] PHST- 2026/02/24 00:00 [accepted] PHST- 2026/05/01 06:35 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 05:20 [entrez] PHST- 2026/04/27 00:00 [pmc-release] AID - S2048679026100913 [pii] AID - 10.1017/jns.2026.10091 [doi] PST - epublish SO - J Nutr Sci. 2026 Apr 27;15:e28. doi: 10.1017/jns.2026.10091. eCollection 2026. PMID- 42064999 OWN - NLM STAT- MEDLINE DCOM- 20260521 LR - 20260813 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 15 DP - 2026 TI - Association of gut microbiota dietary index with MAFLD and the risk of liver fibrosis: the mediating effect of vitamins. PG - e23 LID - 10.1017/jns.2026.10093 [doi] LID - e23 AB - Metabolic dysfunction-associated fatty liver disease (MAFLD) is emerging as the leading cause of chronic liver disease worldwide, with a spectrum ranging from simple steatosis to advanced fibrosis and cirrhosis. Its pathogenesis is multifactorial and involves genetic, metabolic, and gut microbiota factors. Gut microbiota, through the gut-liver axis, plays a crucial role in the progression of MAFLD. Here, we investigated the association between DI-GM, a novel metric reflecting diet-microbiota interactions, MAFLD, and liver fibrosis, with a focus on the mediating role of vitamins. Using data from 13,498 participants across seven NHANES cycles (2007-2018), we found that higher DI-GM scores, indicative of a healthier gut microbiota-promoting diet, were associated with a reduced prevalence of MAFLD (OR = 0.93, 95% CI = 0.88-0.99) and high-risk liver fibrosis (OR = 0.94, 95% CI = 0.90-0.98) in fully adjusted models. Notably, the relationship between DI-GM and MAFLD and the risk of liver fibrosis is largely mediated by specific vitamins and carotenoids, with vitamin C and cis-beta-carotene emerging as key mediators. These findings suggest that dietary interventions targeting the gut microbiota and vitamin supplementation could offer new strategies for the prevention and management of MAFLD. Our study provides the first comprehensive evidence linking DI-GM to MAFLD and the risk of liver fibrosis, highlighting the potential of diet and nutrition to modulate metabolic liver diseases. Future research should focus on elucidating the underlying mechanisms and validating these findings through prospective studies and clinical trials. CI - (c) The Author(s) 2026. FAU - Han, Jinlu AU - Han J AD - Tongren Hospital Shanghai Jiaotong University School of Medicine, China. ROR: https://ror.org/01r8rcr36 FAU - Zhou, Teng AU - Zhou T AD - Fudan University Shanghai Cancer Center, China. FAU - Chen, Jiong AU - Chen J AD - Tongren Hospital Shanghai Jiaotong University School of Medicine, China. ROR: https://ror.org/01r8rcr36 FAU - Xu, Ling AU - Xu L AD - Tongren Hospital Shanghai Jiaotong University School of Medicine, China. ROR: https://ror.org/01r8rcr36 FAU - Shan, Wen AU - Shan W AD - No 2 People's Hospital of Fuyang City, China. FAU - Zhang, Qinghui AU - Zhang Q AUID- ORCID: 0000-0003-2164-6452 AD - Tongren Hospital Shanghai Jiaotong University School of Medicine, China. ROR: https://ror.org/01r8rcr36 LA - eng PT - Journal Article DEP - 20260413 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 RN - 0 (Vitamins) SB - IM MH - *Gastrointestinal Microbiome MH - *Non-alcoholic Fatty Liver Disease/complications/epidemiology/microbiology MH - Nutrition Assessment MH - *Liver Cirrhosis/epidemiology/etiology/microbiology/prevention & control MH - Risk Factors MH - *Diet/adverse effects/statistics & numerical data MH - Mediation Analysis MH - Nutrition Surveys MH - Prevalence MH - Vitamins/administration & dosage MH - Dietary Supplements MH - Cross-Sectional Studies MH - Humans MH - Male MH - Female MH - Infant, Newborn MH - Infant MH - Child, Preschool MH - Child MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged MH - Aged MH - United States/epidemiology PMC - PMC13126062 OTO - NOTNLM OT - Dietary Index of Gut Microbiota OT - dietary nutrition OT - liver fibrosis OT - metabolic-associated fatty liver disease OT - vitamin mediation COIS- The authors declare no competing interests. EDAT- 2026/05/01 06:34 MHDA- 2026/05/01 13:48 PMCR- 2026/04/13 CRDT- 2026/05/01 05:20 PHST- 2025/04/22 00:00 [received] PHST- 2026/01/19 00:00 [revised] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/05/01 13:48 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 05:20 [entrez] PHST- 2026/04/13 00:00 [pmc-release] AID - S2048679026100937 [pii] AID - 10.1017/jns.2026.10093 [doi] PST - epublish SO - J Nutr Sci. 2026 Apr 13;15:e23. doi: 10.1017/jns.2026.10093. eCollection 2026. PMID- 42064996 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 15 DP - 2026 TI - High risk of disordered eating is associated with body composition, behavioural factors, and perceived stress among university students: a cross-sectional study from the UAE. PG - e25 LID - 10.1017/jns.2026.10089 [doi] LID - e25 AB - Disordered eating (DE) significantly affects both physical and mental health, contributing to morbidity, mortality, and considerable global healthcare costs. This cross-sectional study assessed the prevalence of high-risk DE and examined its associations with body composition, behavioural factors, diet quality, and perceived stress among university students in the United Arab Emirates. A total of 911 students were recruited using non-probability quota sampling (50.49% female). Body composition was measured using a TANITA BC-420MA body composition monitor. Usual dietary intake was assessed via a validated 65-item food frequency questionnaire. DE risk was assessed using the Eating Attitudes Test (EAT-26) and perceived stress using the PSS-10. Analysis included linear regression and independent-samples t-test (p < 0.05). High-risk DE (EAT-26 >/= 20) prevalence was 30.3%. High-risk DE was significantly associated with higher body fat percentage (beta = 0.121, p < 0.001), fat mass (beta = 0.148, p < 0.001), fat-free mass (beta = 0.079, p = 0.017), lean mass (beta = 0.08, p = 0.016), total body water (beta = 0.084, p = 0.011), and lower total body water percentage (beta = -0.131, p < 0.001). High-risk students also reported higher intakes of fibre (beta = 0.12, p = 0.018), beta-carotene (beta = 0.14, p = 0.025), vitamin A (beta = 0.13, p = 0.034), B12 (beta = 0.15, p = 0.043), folate (beta = 0.16, p = 0.006), and vitamin D (beta = 0.16, p = 0.036). Compared with the low-risk group, high-risk DE was associated with higher adiposity markers and slightly higher perceived stress, and differed in selected nutrient intakes; sociodemographic characteristics were largely similar between groups except for smoking status. These findings support the implementation of targeted prevention strategies, including nutrition education, routine screening, and culturally tailored programmes, for young adults in the UAE. CI - (c) The Author(s) 2026. FAU - Cheikh Ismail, Leila AU - Cheikh Ismail L AD - Department of Clinical Nutrition and Dietetics, University of Sharjah, United Arab Emirates. ROR: https://ror.org/00engpz63 AD - Nuffield Department of Women's & Reproductive Health, University of Oxford, UK. ROR: https://ror.org/052gg0110 FAU - Faris, MoezAlIslam AU - Faris M AD - Department of Clinical Nutrition and Dietetics, Applied Science Private University, Jordan. FAU - Abdelrahim, Dana N AU - Abdelrahim DN AUID- ORCID: 0000-0002-5111-7132 AD - Research Institute for Medical and Health Sciences, University of Sharjah, United Arab Emirates. FAU - Zeb, Falak AU - Zeb F AD - Research Institute for Medical and Health Sciences, University of Sharjah, United Arab Emirates. FAU - Mohamad, Maysm N AU - Mohamad MN AUID- ORCID: 0000-0002-6396-6625 AD - Department of Nutrition and Health, United Arab Emirates University, United Arab Emirates. ROR: https://ror.org/01km6p862 FAU - Amer, Enas AU - Amer E AD - Department of Clinical Nutrition and Dietetics, University of Sharjah, United Arab Emirates. ROR: https://ror.org/00engpz63 FAU - Alali, Maram AU - Alali M AD - Department of Clinical Nutrition and Dietetics, University of Sharjah, United Arab Emirates. ROR: https://ror.org/00engpz63 FAU - Draghmeh, Marianna AU - Draghmeh M AD - Department of Clinical Nutrition and Dietetics, University of Sharjah, United Arab Emirates. ROR: https://ror.org/00engpz63 FAU - Ben-Mustafa, Najat AU - Ben-Mustafa N AD - Department of Clinical Nutrition and Dietetics, University of Sharjah, United Arab Emirates. ROR: https://ror.org/00engpz63 FAU - Stojanovska, Lily AU - Stojanovska L AD - Institute for Health and Sport, Victoria University, Australia. FAU - Al Dhaheri, Ayesha Salem AU - Al Dhaheri AS AUID- ORCID: 0000-0002-7634-3531 AD - Department of Nutrition and Health, United Arab Emirates University, United Arab Emirates. ROR: https://ror.org/01km6p862 LA - eng PT - Journal Article DEP - 20260415 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - *Body Composition MH - United Arab Emirates/epidemiology MH - Male MH - *Students MH - Universities MH - Young Adult MH - *Feeding and Eating Disorders/epidemiology/psychology MH - Subjective Stress MH - Diet MH - *Feeding Behavior MH - Adult MH - Risk Factors MH - Adolescent MH - *Stress, Psychological MH - Prevalence MH - Surveys and Questionnaires PMC - PMC13126061 OTO - NOTNLM OT - Anthropometry OT - Body composition OT - Diet quality OT - Disordered eating OT - Eating attitudes OT - Perceived stress OT - University students COIS- The author(s) declare none. EDAT- 2026/05/01 06:34 MHDA- 2026/05/01 06:35 PMCR- 2026/04/15 CRDT- 2026/05/01 05:20 PHST- 2025/12/25 00:00 [received] PHST- 2026/01/26 00:00 [revised] PHST- 2026/02/13 00:00 [accepted] PHST- 2026/05/01 06:35 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 05:20 [entrez] PHST- 2026/04/15 00:00 [pmc-release] AID - S2048679026100895 [pii] AID - 10.1017/jns.2026.10089 [doi] PST - epublish SO - J Nutr Sci. 2026 Apr 15;15:e25. doi: 10.1017/jns.2026.10089. eCollection 2026. PMID- 42064155 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260501 LR - 20260813 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Gut microbiota profiles in anorexia nervosa: associations with disease severity, BMI, and history of childhood trauma. PG - 1759115 LID - 10.3389/fpsyt.2026.1759115 [doi] LID - 1759115 AB - STUDY OBJECTIVES: Emerging evidence suggests a possible link between anorexia nervosa (AN) and alterations in the gut microbiota. This study aimed to characterize the gut microbiota profile in a cohort of Chinese female patients with AN. METHOD: A comparative analysis of the gut microbiota was conducted between 30 female patients with AN and 30 sex- and age-matched healthy controls (HCs). Fecal samples were collected for 16S rRNA gene sequencing analysis. All participants were assessed using the Eating Disorder Inventory (EDI) and the Childhood Trauma Questionnaire (CTQ). Bioinformatics analysis was performed using QIIME2, and statistical analyses were carried out with SPSS 26.0 and R software. Correlations between microbiota differences and body mass index (BMI), EDI, and CTQ were further investigated. RESULTS: The analysis revealed differences in beta diversity and the abundances of specific microbial taxa between the two groups; however, no significant differences were observed in alpha diversity nor in the associations between gut microbiota and BMI, disease severity, or childhood trauma. CONCLUSIONS: This study identified limited differences in the gut microbiota composition between patients with AN and HCs. Critically, no robust associations between gut microbiota and clinical features were found after rigorous multiple comparison correction. While nominal (uncorrected) correlations were observed between the specific microbiota and psychological traits, these results are exploratory and should be considered hypothesis-generating. They highlight a potential avenue for future research but require validation in larger, longitudinal cohorts to determine their reproducibility and biological significance. CI - Copyright (c) 2026 Wang, Wang, Ma, Liu, Li and Zhang. FAU - Wang, Meiou AU - Wang M AD - Mental Health Center, National Center for Mental Disorders, West China Hospital, Sichuan University, Chengdu, China. FAU - Wang, Yu AU - Wang Y AD - Mental Health Center, National Center for Mental Disorders, West China Hospital, Sichuan University, Chengdu, China. FAU - Ma, Jing AU - Ma J AD - Mental Health Center, National Center for Mental Disorders, West China Hospital, Sichuan University, Chengdu, China. FAU - Liu, Yang AU - Liu Y AD - Mental Health Center, National Center for Mental Disorders, West China Hospital, Sichuan University, Chengdu, China. FAU - Li, Jin AU - Li J AD - Mental Health Center, National Center for Mental Disorders, West China Hospital, Sichuan University, Chengdu, China. FAU - Zhang, Lan AU - Zhang L AD - Mental Health Center, National Center for Mental Disorders, West China Hospital, Sichuan University, Chengdu, China. LA - eng PT - Journal Article DEP - 20260415 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13125984 OTO - NOTNLM OT - anorexia nervosa OT - childhood trauma OT - diversity OT - eating disorder OT - gut microbiota COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/01 06:34 MHDA- 2026/05/01 06:35 PMCR- 2026/04/15 CRDT- 2026/05/01 05:11 PHST- 2025/12/02 00:00 [received] PHST- 2026/03/19 00:00 [revised] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/05/01 06:35 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 05:11 [entrez] PHST- 2026/04/15 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1759115 [doi] PST - epublish SO - Front Psychiatry. 2026 Apr 15;17:1759115. doi: 10.3389/fpsyt.2026.1759115. eCollection 2026. PMID- 42064151 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260501 LR - 20260813 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Faecal inflammatory protein markers in children with autism spectrum disorder are comparable to their healthy siblings. PG - 1792801 LID - 10.3389/fpsyt.2026.1792801 [doi] LID - 1792801 AB - BACKGROUND: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition often accompanied by gastrointestinal (GI) symptoms. Inflammatory proteins in stool have been proposed as potential biomarkers, but evidence remains inconsistent. We compared fecal levels of alpha1-antitrypsin (A1AT), immunoglobulin A (IgA), and calprotectin (Cal) in 57 children with ASD and 57 biological siblings without ASD. Sibling designs are now preferred to disentangle ASD-specific biology from shared environmental and microbiome factors. Participants were carefully screened to exclude recent antibiotic use, digestive problems, gastrointestinal infections, and abnormal dietary patterns, thereby controlling for major factors known to influence gut inflammatory markers. METHODS: Stool samples were thawed, freeze-dried, and proteins extracted using ammonium bicarbonate buffer with sodium deoxycholate. After BCA quantification, samples were reduced, alkylated, spiked with stable isotope-labelled peptides, and digested with trypsin. Peptides were purified and analyzed by UHPLC-MS/MS (Agilent 6495A) in dynamic SRM mode. Quantification used internal standards and normalization to total protein. Ratios of IgA1/IgA2 and S100A8/S100A9 were calculated. ASD severity was evaluated using the Childhood Autism Rating Scale (CARS). RESULTS: Children with ASD showed trends toward higher IgA and calprotectin and lower alpha1-antitrypsin compared with siblings, but differences were not statistically significant. Subgroup analysis suggested different distribution patterns in moderate versus severe ASD, including higher IgA in the moderate group and altered S100A8/S100A9 ratio in the severe group. These subgroup findings were exploratory, derived from critically underpowered post-hoc analyses (severe subgroup: n = 11 pairs, ~18% power for medium effects), and should be considered hypothesis-generating only, pending validation in adequately powered pre-registered studies. CONCLUSIONS: The results are consistent with recent meta-analyses reporting no consistent evidence of gut inflammation in ASD. Larger, sex-matched studies with full assay validation are needed to clarify the role of stool proteins in ASD. CI - Copyright (c) 2026 Osredkar, Finderle, Godnov, Jekovec-Vrhovsek, Vidova, Elliott, Fabjan, Avgustin, Osredkar and Kumer. FAU - Osredkar, Josko AU - Osredkar J AD - Institute of Clinical Chemistry and Biochemistry, University Medical Centre Ljubljana, Ljubljana, Slovenia. AD - Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia. FAU - Finderle, Petra AU - Finderle P AD - Institute of Clinical Chemistry and Biochemistry, University Medical Centre Ljubljana, Ljubljana, Slovenia. FAU - Godnov, Uros AU - Godnov U AD - The Faculty of Mathematics, Natural Sciences and Information Technologies, University of Ljubljana, Koper, Slovenia. FAU - Jekovec-Vrhovsek, Maja AU - Jekovec-Vrhovsek M AD - Center for Autism, Unit of Child Psychiatry, University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia. FAU - Vidova, Veronika AU - Vidova V AD - Research Centre for Toxic Compounds in the Environment (RECETOX), Faculty of Science, Masaryk University, Brno, Czechia. AD - Environmental Exposure Assessment Research Infrastructure-Czech Republic (EIRENE-CZ), Brno, Czechia. FAU - Elliott, James Price AU - Elliott JP AD - Research Centre for Toxic Compounds in the Environment (RECETOX), Faculty of Science, Masaryk University, Brno, Czechia. AD - Environmental Exposure Assessment Research Infrastructure-Czech Republic (EIRENE-CZ), Brno, Czechia. FAU - Fabjan, Teja AU - Fabjan T AD - Institute of Clinical Chemistry and Biochemistry, University Medical Centre Ljubljana, Ljubljana, Slovenia. FAU - Avgustin, Gorazd AU - Avgustin G AD - Department of Microbiology, Biotechnical Faculty, University of Ljubljana, Domzale, Slovenia. FAU - Osredkar, Damjan AU - Osredkar D AD - Division of Pediatrics, Department of Child, Adolescent and Developmental Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia. AD - Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. FAU - Kumer, Kristina AU - Kumer K AD - Institute of Clinical Chemistry and Biochemistry, University Medical Centre Ljubljana, Ljubljana, Slovenia. LA - eng PT - Journal Article DEP - 20260415 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13125985 OTO - NOTNLM OT - alpha-1-antitrypsin OT - autism spectrum disorder OT - calprotectin OT - immunoglobulin A OT - siblings OT - stool samples COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author JO declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/05/01 06:34 MHDA- 2026/05/01 06:35 PMCR- 2026/04/15 CRDT- 2026/05/01 05:11 PHST- 2026/01/21 00:00 [received] PHST- 2026/03/03 00:00 [revised] PHST- 2026/03/24 00:00 [accepted] PHST- 2026/05/01 06:35 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 05:11 [entrez] PHST- 2026/04/15 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1792801 [doi] PST - epublish SO - Front Psychiatry. 2026 Apr 15;17:1792801. doi: 10.3389/fpsyt.2026.1792801. eCollection 2026. PMID- 42063741 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260813 IS - 2731-085X (Electronic) IS - 2731-085X (Linking) VI - 5 IP - 1 DP - 2026 TI - Investigating food-related behaviors in Smith-Magenis syndrome: tailoring a questionnaire for a rare disease. PG - 49 LID - 10.1007/s44162-026-00193-3 [doi] LID - 49 AB - PURPOSE: Accurate measurement is essential for tracking changes in clinical outcomes. Individuals with Smith-Magenis syndrome (SMS) exhibit challenging and unique food-related behaviors. We sought to determine the best tool to capture their unique food-related behaviors. METHODS: We conducted focus groups with caregivers of individuals with SMS to evaluate two commonly used questionnaires for food-related behaviors- the Food Related Problems Questionnaire (FRPQ) and the Hyperphagia Questionnaire for Clinical Trials (HQ-CT). Based on caregiver input and clinical expertise, we adapted these existing measures into a new tool: the SMS-FRPQ. We then validated this instrument for internal consistency and concurrent validity using online responses from 125 caregivers. RESULTS: Caregivers (n = 24) indicated neither the FRPQ or HQ-CT fully captured their child's food-related behaviors; however, the newly developed SMS-FRPQ was deemed comprehensive by a new group of caregivers (n = 19). The SMS-FRPQ demonstrated strong internal consistency, with a Cronbach's alpha of alpha = 0.87 [0.84-0.90]. Factor analysis indicated a three-factor model was a good fit (comparative fit index (CFI) = 0.9, Tucker-Lewis index (TLI) = 0.88). The three factors each showed good internal consistency: Desire for Food, alpha = 0.80 [0.74-0.85]; Takes Food, alpha = 0.87 [0.83-0.90]; Satiety Impairment, alpha = 0.83 [0.77-0.87]. The SMS-FRPQ showed higher internal reliability than the FRPQ. Concurrent validity was supported through alignment with similar items from the HQ-CT or Behavioral Problems Inventory (BPI-01). CONCLUSIONS: The SMS-FRPQ has 14 items across 3 different factors and 5 additional clinically relevant items. This validated tool may be useful for tracking food-related behavior outcomes in clinical trials for this high-risk population. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s44162-026-00193-3. CI - (c) The Author(s) 2026. FAU - Elatrash, Citrine AU - Elatrash C AD - Department of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, 1100 Bates St., Houston, TX 77030 USA. ROR: https://ror.org/02pttbw34. GRID: grid.39382.33. ISNI: 0000 0001 2160 926X FAU - Wilson, Theresa A AU - Wilson TA AD - Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030 USA. ROR: https://ror.org/02pttbw34. GRID: grid.39382.33. ISNI: 0000 0001 2160 926X FAU - Wood, Alexis C AU - Wood AC AD - Department of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, 1100 Bates St., Houston, TX 77030 USA. ROR: https://ror.org/02pttbw34. GRID: grid.39382.33. ISNI: 0000 0001 2160 926X FAU - Elsea, Sarah H AU - Elsea SH AD - Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030 USA. ROR: https://ror.org/02pttbw34. GRID: grid.39382.33. ISNI: 0000 0001 2160 926X AD - BCM-Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030 USA. ROR: https://ror.org/02pttbw34. GRID: grid.39382.33. ISNI: 0000 0001 2160 926X FAU - Sisley, Stephanie AU - Sisley S AD - Department of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, 1100 Bates St., Houston, TX 77030 USA. ROR: https://ror.org/02pttbw34. GRID: grid.39382.33. ISNI: 0000 0001 2160 926X LA - eng PT - Journal Article DEP - 20260429 PL - Germany TA - J Rare Dis (Berlin) JT - Journal of rare diseases (Berlin, Germany) JID - 9918522486706676 PMC - PMC13124879 OTO - NOTNLM OT - Food-related behaviors OT - Hyperphagia OT - Obesity OT - Questionnaire development OT - Smith-Magenis syndrome COIS- Competing interestsFinancial interests: Both SHE and SS have received research and consulting funds from Rhythm Pharmaceuticals. SS has received research funds from NIH and Eli Lilly and Company. SHE has research funding from the NIH, PTC Therapeutics, Speragen, Inc, and PRISMS, Inc. PRISMS, Inc. supports the SMS Patient Registry, which is housed at Baylor College of Medicine. All other authors declare no financial conflicts of interest. Non-financial interests: none. EDAT- 2026/05/01 06:34 MHDA- 2026/05/01 06:35 PMCR- 2026/04/29 CRDT- 2026/05/01 05:07 PHST- 2025/08/21 00:00 [received] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/05/01 06:35 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 05:07 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - 193 [pii] AID - 10.1007/s44162-026-00193-3 [doi] PST - ppublish SO - J Rare Dis (Berlin). 2026;5(1):49. doi: 10.1007/s44162-026-00193-3. Epub 2026 Apr 29. PMID- 42063118 OWN - NLM STAT- MEDLINE DCOM- 20260619 LR - 20260813 IS - 1742-4755 (Electronic) IS - 1742-4755 (Linking) VI - 23 IP - 1 DP - 2026 Apr 30 TI - Protocol of the Temporality, Eating and Metabolic health during PreconceptiOn (TEMPO) study in females with overweight and obesity: a prospective observational cohort nested within a preconception lifestyle intervention program. LID - 10.1186/s12978-026-02347-4 [doi] LID - 123 AB - INTRODUCTION: Human reproduction is tightly regulated by circadian and metabolic signals. However, the extent to which alterations in these systems affect fertility, especially in females with overweight or obesity who are at increased risk of infertility, remains poorly understood. This study, nested within the Healthy Early Life Moments in Singapore (HELMS) integrated lifestyle intervention program, aims to: (i) examine the associations between changes in circadian behavior and metabolic health indicators over a 3-month period and subsequent reproductive outcomes during a year of conception attempts, (ii) identify risk factors associated with these changes, and (iii) elucidate the biological mechanisms underpinning these relationships in females attempting to conceive. METHODS: This prospective observational cohort study will enroll 283 females with a BMI of 25-40 kg/m(2) participating in the HELMS program at KK Women's and Children's Hospital, Singapore. Participants will be followed for one year as they attempt to conceive. At baseline and at the 3-month mark, circadian behavior will be assessed using validated questionnaires, tracking diaries, and digital wearables. Metabolic health will be evaluated through anthropometry, body fat composition, a metabolic syndrome score, and an insulin resistance index. Blood samples will be collected to analyze metabolic biomarkers and gene expression levels. We will use modified Poisson regression models to examine associations with the clinical pregnancy rate (primary outcome) and discrete-time proportional hazards models to estimate associations with fecundability (secondary outcome) within one year of conception attempts. DISCUSSION: This study is pivotal for identifying potential novel modifiable risk factors to address low fertility rates. Insights from this research will generate hypotheses for interventions designed to enhance preconception care. By screening and managing circadian behaviors and metabolic profiles among females with overweight and obesity, these strategies may benefit those experiencing unexplained infertility. Ultimately, this approach could foster a shift towards a more holistic and patient-centered model of reproductive healthcare. CI - (c) 2026. The Author(s). FAU - Loy, See Ling AU - Loy SL AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, 229899, Singapore. loyseeling@duke-nus.edu.sg. AD - Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore. loyseeling@duke-nus.edu.sg. AD - SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore, Singapore. loyseeling@duke-nus.edu.sg. FAU - Ku, Chee Wai AU - Ku CW AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, 229899, Singapore. AD - Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore. AD - SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Pek, Jun Wei AU - Pek JW AD - Temasek Life Sciences Laboratory, Singapore, Singapore. AD - Department of Biological Sciences, National University of Singapore, Singapore, Singapore. FAU - Cheung, Yin Bun AU - Cheung YB AD - Program in Health Services & Systems Research and Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore. AD - Tampere Centre for Child, Adolescent and Maternal Health Research, Tampere University, Tampere, Finland. FAU - Leow, Melvin Khee Shing AU - Leow MKS AD - Endocrinology, Tan Tock Seng Hospital, Singapore, Singapore. AD - Institute for Human Development and Potential, Singapore Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. FAU - Cheng, Tuck Seng AU - Cheng TS AD - National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom. FAU - Chong, Mary Foong-Fong AU - Chong MF AD - Institute for Human Development and Potential, Singapore Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. AD - Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore. FAU - Godfrey, Keith M AU - Godfrey KM AD - Medical Research Council Lifecourse Epidemiology Centre, University of Southampton, Southampton, United Kingdom. AD - National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom. FAU - Yap, Fabian AU - Yap F AD - Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore. AD - SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore, Singapore. AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. AD - Endocrinology Service, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Chan, Jerry Kok Yen AU - Chan JKY AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, 229899, Singapore. AD - Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore. AD - SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore, Singapore. LA - eng GR - MOH-001537-01/National Medical Research Council/ PT - Journal Article PT - Observational Study DEP - 20260430 PL - England TA - Reprod Health JT - Reproductive health JID - 101224380 SB - IM MH - Humans MH - Female MH - Prospective Studies MH - *Obesity/complications/physiopathology MH - *Preconception Care/methods MH - *Overweight/complications/physiopathology MH - Pregnancy MH - Adult MH - Singapore MH - Life Style MH - Circadian Rhythm MH - Body Mass Index PMC - PMC13281643 OAB - Human reproduction is shaped by the body's internal clock and metabolism, but it is not yet clear how changes in these systems affect fertility, particularly in women with overweight or obesity, who are at higher risk of infertility. This study, part of the Healthy Early Life Moments in Singapore (HELMS) program, aims to better understand these links. A total of 283 women with a body mass index between 25 and 40 kg/m(2) will be recruited at KK Women's and Children's Hospital, Singapore, and followed for one year while trying to conceive. At baseline and 3-month follow-up, participants' daily routines, including the timing of eating and sleep, will be recorded using questionnaires, diaries, and wearable devices. Their metabolic health will be assessed through body fat, waist size, blood sugar control, and blood tests for biomarkers and gene activity. Researchers will analyze how changes in these patterns relate to the chances of becoming pregnant and the time it takes to conceive. This work is important because it may reveal lifestyle and health factors that can be modified to improve fertility. The findings will help shape new approaches to support women before pregnancy. By addressing daily routines such as meal timing and sleep, alongside metabolic health, this study may offer practical strategies for women struggling to conceive without a clear medical cause identified through standard reproductive investigations. In the long run, this approach could lead to more personalized and supportive fertility care that looks beyond medical treatment to the whole person. OABL- eng OTO - NOTNLM OT - Behavior OT - Chronobiology OT - Chrononutrition OT - Clock gene OT - Female reproductive health OT - Meal timing OT - Preconception OT - Sleep COIS- Declarations. Ethics approval and consent to participate: The HELMS trial was registered at clinicaltrial.gov NCT 05207059 on January 26, 2022. The Centralized Institutional Review Board of SingHealth (2021/2247) approved both the initial HELMS protocol and additional data collection for this TEMPO study. The study is conducted in accordance with the ethical principles outlined in the Declaration of Helsinki. Written informed consent is obtained from all participants before they are included in the study. Consent for publication: Not applicable. Competing interests: Dr Godfrey reported being part of an academic consortium that received research funding from Bayer, BenevolentAI Bio Ltd, Nestec, and Danone outside the submitted work. No other disclosures were reported. EDAT- 2026/05/01 06:34 MHDA- 2026/06/19 06:33 PMCR- 2026/04/30 CRDT- 2026/05/01 00:56 PHST- 2025/09/04 00:00 [received] PHST- 2026/04/25 00:00 [accepted] PHST- 2026/06/19 06:33 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 00:56 [entrez] PHST- 2026/04/30 00:00 [pmc-release] AID - 10.1186/s12978-026-02347-4 [pii] AID - 2347 [pii] AID - 10.1186/s12978-026-02347-4 [doi] PST - epublish SO - Reprod Health. 2026 Apr 30;23(1):123. doi: 10.1186/s12978-026-02347-4. PMID- 42062960 OWN - NLM STAT- MEDLINE DCOM- 20260619 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Apr 30 TI - IL-33 associates with type 2 burden and lung function in paediatric asthma, alongside exploratory IL-33-linked lipid changes. LID - 10.1186/s12887-026-06947-8 [doi] LID - 578 AB - BACKGROUND: Interleukin-33 (IL-33) is an epithelial alarmin positioned upstream of type 2 (T2) inflammation, yet its clinical correlates and systemic molecular context in paediatric asthma remain incompletely defined. We investigated whether circulating IL-33 is associated with objective disease-burden measures and whether IL-33 elevation co-occurs with exploratory plasma lipid differences. METHODS: In a paediatric case-control cohort (August 2023-June 2025; asthma n = 60, controls n = 60), plasma IL-33 was quantified by ELISA and related to spirometry (FEV1, FEV1/FVC, PEF) and T2 markers (blood eosinophils, total IgE, FeNO). Associations were assessed using correlation analyses and multivariable linear regression treating IL-33 as a continuous exposure (mean-centred ln[IL-33]) with adjustment for age, sex, BMI, and group, plus an Age x IL-33 interaction. ROC analyses were used to describe case-control discrimination within the cohort. Untargeted plasma lipidomics was performed in an exploratory discovery subset (asthma n = 8, controls n = 8) to define differential lipids, IL-33-anchored lipid patterns, and an exploratory six-lipid IL-33-linked score; score-trait associations were evaluated as exploratory analyses with group residualization. RESULTS: Compared with controls, children with asthma showed worse lung function and higher T2 burden (all P < 0.001), alongside higher IL-33 (107.1 +/- 38.5 vs. 52.4 +/- 21.6 pg/mL; P < 0.001). Across the cohort, IL-33 correlated inversely with lung function (FEV1 r = - 0.652; FEV1/FVC r = - 0.585; PEF r = - 0.683; all P < 0.001) and positively with T2 markers (eosinophils r = 0.534; IgE r = 0.583; FeNO r = 0.622; all P < 0.001). In multivariable models, ln(IL-33) remained significantly associated with each outcome after adjustment for age, sex, BMI, and group status, whereas the Age x IL-33 interaction was not significant (all P > 0.05). IL-33 showed case-control discrimination within the cohort (AUC 0.92; cut-off 75.4 pg/mL). In the exploratory lipidomics subset, PCA suggested group separation, although this should be interpreted cautiously given the small sample size. Differential lipids were dominated by glycerophospholipids (66.67%), followed by sphingolipids (18.1%). Exploratory IL-33-anchored analyses identified provisional glycerophospholipid/cardiolipin-positive and sphingomyelin-negative lipid patterns. The exploratory IL-33-linked lipid score showed high apparent discrimination within the discovery subset (AUC 0.96; LOOCV AUC 0.97) and, after group residualization, remained directionally associated with lung function and T2 markers. CONCLUSION: In this paediatric case-control cohort, circulating IL-33 was elevated in children with asthma and was significantly associated with objective airflow limitation and systemic type 2 inflammatory burden. Higher IL-33 levels also co-occurred with exploratory plasma lipid differences. These findings should be interpreted as adjusted associations observed within a cross-sectional case-control design and require longitudinal and external validation before any broader biomarker or clinical application can be considered. CI - (c) 2026. The Author(s). FAU - Yu, Yingtan AU - Yu Y AD - Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China. AD - Department of Pediatrics, Affiliated Hospital of Jiangnan University, No. 1000 Hefeng Road, Binhu District, Wuxi, Jiangsu, 214122, P.R. China. FAU - Liu, Wanying AU - Liu W AD - Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China. AD - Department of Pediatrics, Affiliated Hospital of Jiangnan University, No. 1000 Hefeng Road, Binhu District, Wuxi, Jiangsu, 214122, P.R. China. FAU - Li, Xinxu AU - Li X AD - Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China. AD - Department of Pediatrics, Affiliated Hospital of Jiangnan University, No. 1000 Hefeng Road, Binhu District, Wuxi, Jiangsu, 214122, P.R. China. FAU - Chang, Tianzhi AU - Chang T AD - Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China. FAU - Tong, Xiao AU - Tong X AD - Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China. 9862018033@jiangnan.edu.cn. AD - Department of Pediatrics, Affiliated Hospital of Jiangnan University, No. 1000 Hefeng Road, Binhu District, Wuxi, Jiangsu, 214122, P.R. China. 9862018033@jiangnan.edu.cn. LA - eng PT - Journal Article DEP - 20260430 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 RN - 0 (Interleukin-33) RN - 0 (IL33 protein, human) RN - 0 (Biomarkers) RN - 0 (Lipids) RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Humans MH - *Interleukin-33/blood MH - Child MH - Case-Control Studies MH - *Asthma/blood/physiopathology MH - Male MH - Female MH - Biomarkers/blood MH - *Lipids/blood MH - Adolescent MH - Immunoglobulin E/blood MH - Respiratory Function Tests MH - Lipidomics MH - Spirometry PMC - PMC13281470 OTO - NOTNLM OT - Glycerophospholipid remodelling OT - IL-33-lipid score OT - Interleukin-33 OT - Paediatric asthma COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Medical Ethics Committee of the Affiliated Hospital of Jiangnan University (approval number: LS2022112). The study was conducted in accordance with the Declaration of Helsinki and applicable local regulations. Written informed consent was obtained from the parents or legal guardians of all participants, and assent was obtained from children when appropriate. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/01 06:34 MHDA- 2026/06/19 06:32 PMCR- 2026/04/30 CRDT- 2026/05/01 00:47 PHST- 2026/02/27 00:00 [received] PHST- 2026/04/27 00:00 [accepted] PHST- 2026/06/19 06:32 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 00:47 [entrez] PHST- 2026/04/30 00:00 [pmc-release] AID - 10.1186/s12887-026-06947-8 [pii] AID - 6947 [pii] AID - 10.1186/s12887-026-06947-8 [doi] PST - epublish SO - BMC Pediatr. 2026 Apr 30;26(1):578. doi: 10.1186/s12887-026-06947-8. PMID- 42062818 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1365-277X (Electronic) IS - 0952-3871 (Print) IS - 0952-3871 (Linking) VI - 39 IP - 3 DP - 2026 Jun TI - Nutrition Literacy, Hydration Awareness and Food Label Use in School Populations: A Cross-Sectional Study of Students and Teachers Across European Contexts. PG - e70258 LID - 10.1111/jhn.70258 [doi] LID - e70258 AB - BACKGROUND: Nutrition literacy is increasingly recognised as a key determinant of dietary behaviours and long-term public health outcomes. Schools represent strategic settings for strengthening nutrition literacy-related competencies, including hydration awareness and food label use, yet comparative. However, descriptive cross-country evidence across European school contexts remains limited. METHODS: A cross-sectional, school-based survey was conducted among 432 students (aged 11-16 years) and 108 teachers across five European contexts (Italy, Germany, Cyprus, Serbia and Guadeloupe [France]). Culturally adapted questionnaires developed within the Erasmus+ GARDENS project assessed predefined domains of nutrition knowledge (food groups, macronutrient functions, fibre, vitamins and minerals), hydration awareness, food label use and selected sustainability-related concepts. Knowledge items were coded dichotomously (correct/incorrect), and behavioural indicators were analysed descriptively. Cross-country comparisons were exploratory. RESULTS: Teachers in Germany and Italy reported higher levels of hydration awareness (> 90%) and food label use (>/= 75%), whereas lower self-reported food label literacy was observed in Guadeloupe (48%). Among students, incorrect responses to nutrient-function items (defined as misconceptions) were observed in 40% of the overall sample, with higher proportions in Guadeloupe and Serbia. Cross-country variability was present across all assessed domains. CONCLUSIONS: Marked substantial descriptive differences in nutrition literacy knowledge, hydration awareness and food label use were observed across school populations in selected European contexts. These findings provide baseline public health evidence supporting the integration of nutrition literacy-particularly hydration and food labelling-into school-based health promotion strategies, with attention to equity and contextual factors. These findings provide baseline evidence to inform school-based health promotion strategies and highlight the relevance of contextual and equity-related considerations. Further research using validated instruments and inferential designs is warranted. CI - (c) 2026 The Author(s). Journal of Human Nutrition and Dietetics published by John Wiley & Sons Ltd on behalf of British Dietetic Association. FAU - Coradduzza, Donatella AU - Coradduzza D AUID- ORCID: 0000-0002-8978-0490 AD - Department of Biomedical Sciences, University of Sassari, Sassari, Italy. FAU - Boccuzzi, Giannagelo AU - Boccuzzi G AD - Mine Vaganti NGO, Sassari, Italy. FAU - Masi, Giancarlo AU - Masi G AD - Mine Vaganti NGO, Sassari, Italy. FAU - Porstner, Christian AU - Porstner C AD - NGO NEST Berlin e.V., Berlin, Germany. FAU - Dube, Raphael AU - Dube R AD - Universite des Antilles, Guadeloupe, France. FAU - Nikolaou, Nikolas AU - Nikolaou N AD - Department of Education, University of Cyprus, Nicosia, Cyprus. FAU - Sedda, Stefania AU - Sedda S AD - Department of Biomedical Sciences, University of Sassari, Sassari, Italy. FAU - Merdovic, Maja AU - Merdovic M AD - Institute for Public Health of Serbia, Belgrade, Serbia. FAU - Medici, Serenella AU - Medici S AD - Department of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, Sassari, Italy. FAU - Carru, Ciriaco AU - Carru C AUID- ORCID: 0000-0002-6985-4907 AD - Department of Biomedical Sciences, University of Sassari, Sassari, Italy. FAU - Solinas, Roberto AU - Solinas R AD - Mine Vaganti NGO, Sassari, Italy. FAU - Pirina, Maria Grazia AU - Pirina MG AD - Mine Vaganti NGO, Sassari, Italy. LA - eng GR - 2023-1-FR01-KA220-SCH-000160068/Erasmus+ Program/ PT - Journal Article PL - England TA - J Hum Nutr Diet JT - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JID - 8904840 SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Food Labeling/statistics & numerical data MH - *Health Knowledge, Attitudes, Practice MH - Schools MH - *Health Literacy/statistics & numerical data MH - *Students/statistics & numerical data/psychology MH - Child MH - Adolescent MH - Male MH - Female MH - Europe MH - *School Teachers/statistics & numerical data/psychology MH - Surveys and Questionnaires MH - European People MH - *Drinking MH - Serbia PMC - PMC13133250 OTO - NOTNLM OT - food labelling OT - health promotion OT - nutrition literacy, hydration OT - nutrition literacy, public health nutrition OT - school health OT - sustainability COIS- The authors declare no conflicts of interest. EDAT- 2026/05/01 06:34 MHDA- 2026/05/01 06:35 PMCR- 2026/05/01 CRDT- 2026/05/01 00:03 PHST- 2026/04/08 00:00 [revised] PHST- 2026/01/23 00:00 [received] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/05/01 06:35 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 00:03 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - JHN70258 [pii] AID - 10.1111/jhn.70258 [doi] PST - ppublish SO - J Hum Nutr Diet. 2026 Jun;39(3):e70258. doi: 10.1111/jhn.70258. PMID- 42062552 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260430 LR - 20260813 IS - 2730-664X (Electronic) IS - 2730-664X (Linking) VI - 6 IP - 1 DP - 2026 Apr 30 TI - Measuring gross motor skills in African children using the PERF-FIT. LID - 10.1038/s43856-026-01592-9 [doi] LID - 258 AB - BACKGROUND: Africa is facing a rising prevalence of non-communicable diseases (NCDs), driven by shifts in lifestyle and dietary habits. Children with delays in motor coordination are less likely to participate in physical activity, active play, and sports, placing them at increased risk for obesity, reduced physical fitness, and cardiovascular diseases. Existing motor performance tests for school-aged children were not designed for African populations and lack culturally valid normative data. METHODS: As part of an African-led initiative, the PERFormance and FITness test battery (PERF-FIT) was developed to assess motor performance and motor skill-related physical fitness in children aged 6-12 years. The PERF-FIT test battery is open-source, contextually relevant, and tailored for low-resource settings. This study involved the collection of motor performance data from a large sample of African children to establish age- and sex-specific normative values. RESULTS: This study generates normative data for motor skills in African children aged 6-12 years (n = 2604), stratified by age and sex. These norms complement the previously validated psychometric properties of the PERF-FIT, confirming its reliability and applicability across diverse African contexts. CONCLUSIONS: The PERF-FIT test battery provides a culturally appropriate and psychometrically sound tool for assessing motor performance in African children. It serves as a valuable resource for clinicians, educators, and policymakers to monitor motor skill related physical fitness and detect motor delays in children aged 6-12 years in African countries. CI - (c) 2026. The Author(s). FAU - Smits-Engelsman, Bouwien AU - Smits-Engelsman B AUID- ORCID: 0000-0003-0632-3276 AD - Physical Activity, Sport and Recreation (PhASRec), Faculty Health Sciences, North-West University, Potchefstroom, South Africa. bouwiensmits@hotmail.com. AD - Department of Health & Rehabilitation Sciences, Faculty of Health Sciences, The University of Cape Town, Cape Town, South Africa. bouwiensmits@hotmail.com. FAU - Coetzee, Dane AU - Coetzee D AUID- ORCID: 0000-0002-7166-8353 AD - Physical Activity, Sport and Recreation (PhASRec), Faculty Health Sciences, North-West University, Potchefstroom, South Africa. FAU - Doe-Asinyo, Rosemary Xorlanyo AU - Doe-Asinyo RX AUID- ORCID: 0000-0003-1766-8173 AD - Department of Occupational Therapy, College of Health Sciences, University of Ghana, Accra, Ghana. FAU - Ituen, Oluwakemi Adebukola AU - Ituen OA AUID- ORCID: 0009-0004-2241-9205 AD - Department of Physiotherapy, University of Uyo Teaching Hospital, Uyo, Akwa Ibom state, Nigeria. FAU - Farhat, Faical AU - Farhat F AUID- ORCID: 0009-0009-7765-7944 AD - Research Laboratory 'NeuroPediatrie' (LR19ES15), Sfax Medical School, University of Sfax, Sfax, Tunisia. AD - Research Laboratory: Education, Motricity, Sport and Health, EM2S, LR19JS01, High Institute of Sport and Physical Education of Sfax, Sfax, Tunisia. FAU - Melaku Dubale, Yabsra AU - Melaku Dubale Y AUID- ORCID: 0009-0007-5251-7553 AD - Department of Nutrition and Dietetics, Faculty of Public Health, Health Institute, Jimma University, Jimma, Ethiopia. AD - Rehabilitation Research Centre - REVAL, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Belgium. FAU - Verbecque, Evi AU - Verbecque E AUID- ORCID: 0000-0001-8116-1620 AD - Department of Nutrition and Dietetics, Faculty of Public Health, Health Institute, Jimma University, Jimma, Ethiopia. LA - eng PT - Journal Article DEP - 20260430 PL - England TA - Commun Med (Lond) JT - Communications medicine JID - 9918250414506676 PMC - PMC13133362 OAB - This study aimed to make a motor performance test that is suitable for African children aged 6 to 12 years. Many existing tests were developed in other regions and do not reflect the abilities or context of African children. Researchers of an African-led initiative developed the PERFormance and FITness test battery (PERF-FIT), which is free to use and designed for schools, clinics and healthcare workers in low-resource settings. The study describes how data were collected from 2604 children to create age- and sex-specific norms. These results help professionals understand what typical motor skills look like in African children. This tool can support early identification of children at risk for motor delays and health problems based on low motor fitness. OABL- eng COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/05/01 00:32 MHDA- 2026/05/01 00:33 PMCR- 2026/04/30 CRDT- 2026/04/30 23:28 PHST- 2025/06/03 00:00 [received] PHST- 2026/04/08 00:00 [accepted] PHST- 2026/05/01 00:33 [medline] PHST- 2026/05/01 00:32 [pubmed] PHST- 2026/04/30 23:28 [entrez] PHST- 2026/04/30 00:00 [pmc-release] AID - 10.1038/s43856-026-01592-9 [pii] AID - 1592 [pii] AID - 10.1038/s43856-026-01592-9 [doi] PST - epublish SO - Commun Med (Lond). 2026 Apr 30;6(1):258. doi: 10.1038/s43856-026-01592-9. PMID- 42062348 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Apr 30 TI - Feasibility of forecasting self-injurious behavior among autistic youth using wearable sensors and machine learning models. LID - 10.1038/s41598-026-50079-z [doi] LID - 20203 AB - Self-injurious behavior (SIB) is a substantial clinical challenge for many individuals on the autism spectrum, and support strategies are often only reactive. Forecasting of SIB could enable timely support, especially using wearable sensors, but its feasibility is not well understood. We evaluated SIB forecasting using a previously collected dataset (n = 9) comprising motion and physiological data. We compared the performance of four machine learning models-Random Forest, AdaBoost.M2, Long Short-Term Memory (LSTM), and a Double-Stacked LSTM-across five forecast horizons (3s to 120s) and three feature sets: Motion-Only (from accelerometers), Physiological-Only (e.g., heart rate, skin conductance), and Combined. Performance was measured with a range of metrics, using Leave-One-Subject-Out cross-validation. We found a significant main effect of forecast horizon on the Area Under the Precision-Recall Curve; performance rose from near-chance at short horizons to having median scores above chance at one minute or longer. While aggregated results showed no significant differences between models or feature sets, subject-level analysis suggested predictive feasibility and that the optimal model configuration were highly person-specific. Our findings demonstrate that forecasting using wearable sensor data is feasible, but the substantial performance variability highlights a critical need for person-specific approaches to enable the development of clinically useful, proactive support systems. CI - (c) 2026. The Author(s). FAU - Kim, Sunwook AU - Kim S AD - Department of Industrial and Systems Engineering, Virginia Tech, Blacksburg, VA, USA. sunwook@vt.edu. FAU - Cantin-Garside, Kristine D AU - Cantin-Garside KD AD - Global Digital Health Strategy, Johnson & Johnson, Raritan, NJ, USA. FAU - Nussbaum, Maury A AU - Nussbaum MA AD - Department of Industrial and Systems Engineering, Virginia Tech, Blacksburg, VA, USA. LA - eng PT - Journal Article DEP - 20260430 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Wearable Electronic Devices MH - *Self-Injurious Behavior/diagnosis MH - *Machine Learning MH - Feasibility Studies MH - Predictive Learning Models MH - Long Short Term Memory MH - *Autistic Disorder/complications MH - Forecasting/methods MH - Prediction Algorithms MH - Child MH - Female MH - Adolescent MH - Random Forest MH - Boosting Machine Learning Algorithms PMC - PMC13323699 OTO - NOTNLM OT - Autism spectrum disorder OT - Biosensors OT - Challenging behavior OT - Neurodivergence OT - Preventive intervention OT - Remote monitoring COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/05/01 00:32 MHDA- 2026/07/02 00:34 PMCR- 2026/04/30 CRDT- 2026/04/30 23:21 PHST- 2025/09/11 00:00 [received] PHST- 2026/04/20 00:00 [accepted] PHST- 2026/07/02 00:34 [medline] PHST- 2026/05/01 00:32 [pubmed] PHST- 2026/04/30 23:21 [entrez] PHST- 2026/04/30 00:00 [pmc-release] AID - 10.1038/s41598-026-50079-z [pii] AID - 50079 [pii] AID - 10.1038/s41598-026-50079-z [doi] PST - epublish SO - Sci Rep. 2026 Apr 30;16(1):20203. doi: 10.1038/s41598-026-50079-z. PMID- 42057279 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260921 IS - 2162-3279 (Electronic) VI - 16 IP - 5 DP - 2026 May TI - Ecological Factors Associated With Psychological Distress Among Adolescents: The Role of Educational Stress, Peer Victimization, and Physical Activity. PG - e71450 LID - 10.1002/brb3.71450 [doi] LID - e71450 AB - BACKGROUND: Adolescent psychological distress is shaped by influences across educational, familial, peer, and behavioral domains, yet few studies in low- and middle-income countries (LMICs) have examined these determinants within a unified theoretical framework. Guided by Bronfenbrenner's bioecological model, this study investigated ecological factors associated with psychological distress among Bangladeshi adolescents, with particular attention to educational stress, peer victimization, and physical activity. METHODS: A school-based cross-sectional survey was conducted among 501 higher secondary students in Bangladesh. Psychological distress was assessed using the Depression Anxiety and Stress Scale-21, whereas educational stress, family relationship quality, peer relationships, and physical activity were measured using validated instruments. Hierarchical multiple linear regression models evaluated the incremental contribution of theoretically ordered factor blocks. Relative importance analysis (Lindeman-Merenda-Gold method) quantified each factor's proportional contribution to explained variance. Domain-specific regression models were conducted for depression, anxiety, and stress. Heteroskedasticity-consistent (HC3) robust standard errors were applied. RESULTS: The fully adjusted model explained 23.8% of the variance in overall psychological distress. Educational stress (B = 0.56, p < 0.001), female gender (B = 12.32, p < 0.001), and peer victimization (B = 2.07, p < 0.001) were positively associated with distress, whereas physical activity was inversely associated (B = -0.91, p = 0.004). Relative importance analysis indicated that educational stress (20.4%), gender (17.7%), peer victimization (16.8%), and physical activity (15.9%) accounted for the largest proportions of explained variance. Similar patterns were observed across depression, anxiety, and stress subscales. CONCLUSIONS: Psychological distress among Bangladeshi adolescents is associated with the combined influence of academic pressure, peer victimization, gender-related vulnerability, and behavioral health factors. Interventions that address educational stress and peer safety while promoting physical activity may help inform a coordinated and contextually grounded strategy for adolescent mental health prevention in Bangladesh and similar LMIC settings. CI - (c) 2026 The Author(s). Brain and Behavior published by Wiley Periodicals LLC. FAU - Al-Mamun, Firoj AU - Al-Mamun F AUID- ORCID: 0000-0003-4611-9624 AD - CHINTA Research Bangladesh, Dhaka, Bangladesh. AD - Department of Public Health, University of South Asia, Dhaka, Bangladesh. FAU - Nodi, Tasmin Sayeed AU - Nodi TS AUID- ORCID: 0009-0002-3561-4224 AD - CHINTA Research Bangladesh, Dhaka, Bangladesh. FAU - Abdullah, Abu Hasnat AU - Abdullah AH AUID- ORCID: 0000-0001-7375-6085 AD - CHINTA Research Bangladesh, Dhaka, Bangladesh. AD - Department of Public Health, Daffodil International University, Dhaka, Bangladesh. FAU - Hossain, Susmita AU - Hossain S AD - CHINTA Research Bangladesh, Dhaka, Bangladesh. AD - Bangladesh Dental College, Dhaka, Bangladesh. FAU - Hasan, Md Mehedee AU - Hasan MM AUID- ORCID: 0009-0005-3683-3762 AD - CHINTA Research Bangladesh, Dhaka, Bangladesh. FAU - Malakar, Jyotie AU - Malakar J AUID- ORCID: 0009-0007-3171-0039 AD - CHINTA Research Bangladesh, Dhaka, Bangladesh. AD - Department of Maternal and Child Health, National Institute of Preventive and Social Medicine, Dhaka, Bangladesh. FAU - Abdelall, Maysa Mohamed Rabea AU - Abdelall MMR AD - Department of Physical Sport Sciences, College of Sport Sciences and Physical Activity Princess Nourah bint Abdulrahman University, Riyadh. FAU - Mamun, Mohammed A AU - Mamun MA AUID- ORCID: 0000-0002-1728-8966 AD - CHINTA Research Bangladesh, Dhaka, Bangladesh. AD - Department of Public Health, University of South Asia, Dhaka, Bangladesh. LA - eng GR - PNURSP2026R802/Princess Nourah Bint Abdulrahman University Researchers Supporting/ PT - Journal Article PL - United States TA - Brain Behav JT - Brain and behavior JID - 101570837 SB - IM MH - Humans MH - Adolescent MH - Female MH - *Peer Group MH - Male MH - *Crime Victims/psychology MH - Bangladesh MH - Cross-Sectional Studies MH - *Stress, Psychological/psychology MH - *Exercise/psychology MH - *Psychological Distress MH - Students/psychology MH - Anxiety/psychology MH - Depression/psychology MH - *Bullying/psychology PMC - PMC13128966 OTO - NOTNLM OT - adolescent mental health OT - ecological model OT - educational stress OT - peer victimization OT - physical activity OT - psychological distress COIS- The authors declare no conflicts of interest. EDAT- 2026/04/30 06:34 MHDA- 2026/04/30 06:35 PMCR- 2026/04/29 CRDT- 2026/04/30 00:34 PHST- 2026/03/21 00:00 [revised] PHST- 2026/02/23 00:00 [received] PHST- 2026/04/14 00:00 [accepted] PHST- 2026/04/30 06:35 [medline] PHST- 2026/04/30 06:34 [pubmed] PHST- 2026/04/30 00:34 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - BRB371450 [pii] AID - 10.1002/brb3.71450 [doi] PST - ppublish SO - Brain Behav. 2026 May;16(5):e71450. doi: 10.1002/brb3.71450. PMID- 42057239 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260627 LR - 20260813 IS - 2055-0928 (Electronic) IS - 2055-0928 (Linking) VI - 12 IP - 1 DP - 2026 Apr 29 TI - Unraveling the Diet-Learning Nexus: a cross-sectional deep dive into Iranian adolescents' nutrient patterns and learning difficulties. LID - 10.1186/s40795-026-01338-9 [doi] LID - 115 AB - BACKGROUND: learning difficulties (LDs), which encompass deficits in academic achievement and cognitive processing, are associated with significant functional challenges. Research indicates that dietary patterns and nutrient intake represent environmental factors that may exert influence on the phenotypic expression or trajectory of such neurodevelopmental disorders. This study examined the association between nutrient patterns and LDs in school-aged adolescents in Iran. METHODS: A cross-sectional descriptive-analytical study was conducted from March to June 2024 in four secondary schools (two all-female and two all-male) in Jahrom, Iran. A total of 455 male and female adolescents aged 14 to 18 years participated. Adolescents with pre-existing medical conditions (cardiovascular disease, diabetes mellitus, hepatic or renal disease), those following specific dietary regimens, or with incomplete data were excluded. LDs were assessed using the Colorado Learning Difficulties Questionnaire (CLDQ). Dietary intake was assessed via a validated 168-item Food Frequency Questionnaire (FFQ). Seven nutrient patterns (NP) were identified through factor analysis. Anthropometric measurements and socioeconomic variables were also collected. Higher scores of CLDS reflect greater LDs. RESULTS: Adolescents were classified into tertiles based on CLDS. The first tertile of NPs and CLDS was considered as a reference. Moderate adherence to NP4, characterized by higher glutamine and lower glucose, fructose, vitamins C, A, and E, and potassium, was associated with increased odds of being in the highest CLDS tertile in the fully adjusted model (OR 2.50; 95% CI 1.32-4.71). High adherence to NP7, characterized by lower intake of sodium, MUFA, and vitamin D, was associated with lower odds of being in the highest CLDS tertile in the full adjusted model (OR 0.48; 95% CI 0.25-0.91). CONCLUSION: Adherence to a low antioxidant and glucose-content NP diet characterized by higher glutamine and lower intakes of glucose, fructose, vitamins C, A, and E, and potassium was positively associated with LDs in Iranian adolescents. Additionally, high adherence to a low-sodium diet was associated with lower odds of being in the highest CLDS tertile. FAU - Rahmanian, Reza AU - Rahmanian R AUID- ORCID: 0009-0004-0125-5096 AD - Student research committee, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. AD - Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Razeghi-Pirbasti, Ali AU - Razeghi-Pirbasti A AUID- ORCID: 0009-0003-7237-5784 AD - Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Shaygantabar, Mohsen AU - Shaygantabar M AUID- ORCID: 0009-0006-5483-9495 AD - Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Bahreini-Boroujeni, Leyli Zahra AU - Bahreini-Boroujeni LZ AUID- ORCID: 0009-0006-3898-051X AD - Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Jowshan, Mohammad-Reza AU - Jowshan MR AUID- ORCID: 0000-0001-8603-5674 AD - Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. mr.jowshan@gmail.com. AD - Student Research Committee, Iran University of Medical Sciences, Tehran, Iran. mr.jowshan@gmail.com. AD - School of Paramedical, Gerash University of Medical Sciences, Gerash, Iran. mr.jowshan@gmail.com. LA - eng PT - Journal Article DEP - 20260429 PL - England TA - BMC Nutr JT - BMC nutrition JID - 101672434 PMC - PMC13274175 OTO - NOTNLM OT - Cognitive Function OT - Dietary pattern OT - Learning Difficulties OT - Nutrition COIS- Declarations. Ethics approval and consent to participate: The research was approved by the Ethics Committee of the National Nutrition and Food Technology Research Institute at Shahid Beheshti University of Medical Sciences, Iran (IR.SBMU.NNFTRI.REC.1403.016). The study adheres to the principles outlined in the Declaration of Helsinki. Written informed consent was obtained from all participants. For participants under 16 years of age, informed consent was also obtained from their parents or legal guardians before enrollment. All personal information about participants will be kept secure in a database. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/30 06:34 MHDA- 2026/04/30 06:35 PMCR- 2026/04/29 CRDT- 2026/04/30 00:33 PHST- 2026/01/21 00:00 [received] PHST- 2026/04/23 00:00 [accepted] PHST- 2026/04/30 06:35 [medline] PHST- 2026/04/30 06:34 [pubmed] PHST- 2026/04/30 00:33 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - 10.1186/s40795-026-01338-9 [pii] AID - 1338 [pii] AID - 10.1186/s40795-026-01338-9 [doi] PST - epublish SO - BMC Nutr. 2026 Apr 29;12(1):115. doi: 10.1186/s40795-026-01338-9. PMID- 42053809 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261012 IS - 1435-165X (Electronic) IS - 1018-8827 (Print) IS - 1018-8827 (Linking) VI - 35 IP - 8 DP - 2026 Aug TI - Ultra-processed food consumption during pregnancy and emotional and behavioral problems in offspring. PG - 2633-2643 LID - 10.1007/s00787-026-03044-0 [doi] AB - Evidence on prenatal ultra-processed food (UPF) consumption and offspring psychopathological problems remains limited. Therefore, this study assessed the associations between UPF consumption during pregnancy and offspring emotional and behavioral problems. The potential impact of theoretically replacing UPFs with unprocessed or minimally processed foods was also examined using simulation models. The analyses included 201 mother-child pairs from the ECLIPSES study. Dietary intake was assessed using a validated food frequency questionnaire at 12, 24, and 36 weeks of gestation. UPF consumption (%grams/day) was estimated using the NOVA classification system. Children's behavior was assessed at age 4 using the parent-reported Child Behaviour Checklist (1.5 to 5 years), with outcomes defined as borderline/clinical scores. Multivariable-adjusted logistic regression models were fitted. Every 10% grams/day increase in prenatal UPF consumption was associated with higher odds of having children with borderline/clinical scores on several syndrome and broad-band scales: emotionally reactive (Odd ratios [OR]: 1.67; 95% Confidence interval [CI]: 1.06-2.63), aggressive behavior (OR 2.13; 95% CI: 1.18-3.84), internalizing problems (OR: 1.56 95%CI: 1.06-2.31), externalizing problems (OR: 2.00; 95% CI: 1.31-3.07) and total problems (OR: 1.68; 95%CI: 1.12-2.51). Associations were also observed with DSM-oriented scales, including depressive (OR: 2.08; 95%CI: 1.25-3.45), attention deficit/hyperactivity (OR: 1.71; 95%CI: 1.08-2.68) and oppositional defiant problems (OR: 1.85; 95%CI: 1.09-3.13). Replacing 10%grams/day of UPF with equal amounts of unprocessed or minimally processed foods was associated with lower likelihood of children presenting the aforementioned borderline/clinical scores. The findings suggest that prenatal UPF consumption might be associated with adverse emotional and behavioral outcomes in the offspring. CI - (c) 2026. The Author(s). FAU - Becerra-Tomas, Nerea AU - Becerra-Tomas N AUID- ORCID: 0000-0002-4429-6507 AD - Departament de Ciencies Mediques Basiques, Unitat de Salut Publica i Epidemiologia Nutricional, Nutrition and Mental Health (NUTRISAM) research group, Universitat Rovira i Virgili, Carrer St. Llorenc, 21, Reus, 43201, Spain. AD - Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain. FAU - Sans, Josefa Canals AU - Sans JC AUID- ORCID: 0000-0002-6209-9558 AD - Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain. AD - Department of Psychology, Nutrition and Mental Health (NUTRISAM) research group, Universitat Rovira i Virgili, Tarragona, Spain. AD - Department of Psychology, Research Center for Behavioral Assessment (CRAMC), Universitat Rovira i Virgili, Tarragona, Spain. FAU - Jardi, Cristina AU - Jardi C AUID- ORCID: 0000-0002-7946-1488 AD - Departament de Ciencies Mediques Basiques, Unitat de Salut Publica i Epidemiologia Nutricional, Nutrition and Mental Health (NUTRISAM) research group, Universitat Rovira i Virgili, Carrer St. Llorenc, 21, Reus, 43201, Spain. AD - Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain. FAU - Voltas, Nuria AU - Voltas N AUID- ORCID: 0000-0001-8855-0282 AD - Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain. AD - Department of Psychology, Nutrition and Mental Health (NUTRISAM) research group, Universitat Rovira i Virgili, Tarragona, Spain. AD - Department of Psychology, Research Center for Behavioral Assessment (CRAMC), Universitat Rovira i Virgili, Tarragona, Spain. FAU - Hernandez-Martinez, Carmen AU - Hernandez-Martinez C AUID- ORCID: 0000-0001-6328-8679 AD - Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain. AD - Department of Psychology, Nutrition and Mental Health (NUTRISAM) research group, Universitat Rovira i Virgili, Tarragona, Spain. AD - Department of Psychology, Research Center for Behavioral Assessment (CRAMC), Universitat Rovira i Virgili, Tarragona, Spain. FAU - Arija, Victoria AU - Arija V AUID- ORCID: 0000-0002-1758-0975 AD - Departament de Ciencies Mediques Basiques, Unitat de Salut Publica i Epidemiologia Nutricional, Nutrition and Mental Health (NUTRISAM) research group, Universitat Rovira i Virgili, Carrer St. Llorenc, 21, Reus, 43201, Spain. victoria.arija@urv.cat. AD - Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain. victoria.arija@urv.cat. AD - Collaborative Group on Lifestyles, Nutrition, and Tobacco (CENIT), Institut d'Investigacio en Atencio Primaria IDIAP Jordi Gol, Institut Catala de la Salut (ICS), Reus, Spain. victoria.arija@urv.cat. LA - eng PT - Journal Article DEP - 20260429 PL - Germany TA - Eur Child Adolesc Psychiatry JT - European child & adolescent psychiatry JID - 9212296 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Prenatal Exposure Delayed Effects/epidemiology MH - Child, Preschool MH - *Fast Foods/adverse effects/statistics & numerical data MH - Male MH - *Child Behavior Disorders/epidemiology/etiology MH - Infant MH - Adult PMC - PMC13652858 OTO - NOTNLM OT - Behavioral problems OT - Child development OT - Pregnancy OT - Ultra-processed food COIS- Declarations. Ethical statement: The study was designed in agreement with the Declaration of Helsinki and the Tokyo Update. The protocol of the ECLIPSES study by the Ethical Committee of the Jordi Gol Institute for Primary Care Research and the Pere Virgili Institute for Health Research. Consent to participate: Written informed consent was obtained from all the participants in the study. Competing interests: The authors declare no competing interests. EDAT- 2026/04/29 12:43 MHDA- 2026/10/09 17:34 PMCR- 2026/04/29 CRDT- 2026/04/29 11:13 PHST- 2025/07/31 00:00 [received] PHST- 2026/04/19 00:00 [accepted] PHST- 2026/10/09 17:34 [medline] PHST- 2026/04/29 12:43 [pubmed] PHST- 2026/04/29 11:13 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - 10.1007/s00787-026-03044-0 [pii] AID - 3044 [pii] AID - 10.1007/s00787-026-03044-0 [doi] PST - ppublish SO - Eur Child Adolesc Psychiatry. 2026 Aug;35(8):2633-2643. doi: 10.1007/s00787-026-03044-0. Epub 2026 Apr 29. PMID- 42052039 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Relationship between childcare workers' physical literacy and support for promoting children's physical activity. PG - 1807141 LID - 10.3389/fpubh.2026.1807141 [doi] LID - 1807141 AB - INTRODUCTION: Physical literacy (PL) is defined as "the motivation, confidence, physical competence, knowledge, and understanding required to value and take responsibility for engagement in physical activities for life." Previous research suggests that higher parental PL is associated with positive attitudes and involvement in children's physical activity. As approximately 90% of children in Japan attend early childhood education and care settings, the role of childcare workers in supporting children's physical activity has become increasingly important. Therefore, we aimed to examine the characteristics of childcare workers' PL and its association with their support for promoting children's physical activity. METHODS: Secondary data from 201 childcare workers provided by a company managing early childhood education and care facilities were used. PL was assessed using the Physical Literacy for Life self-assessment tool (PL4L). Support for promoting children's physical activity was assessed using five items from a previous study and an additional item developed for this study. The construct validity of the support items was examined using confirmatory factor analysis, and internal consistency was assessed using Cronbach's alpha. The Mann-Whitney U and Kruskal-Wallis tests were used to compare childcare workers' PL scores by gender, sports club participation at each school age, and stage of change for participation in physical activity. Structural equation modeling was used to examine whether childcare workers' PL was related to support for promoting children's physical activity. RESULTS: Childcare workers who had participated in sports clubs during junior high school, high school, or university tended to report higher PL scores than those who had not. PL scores differed by stage of change for participation in physical activity, with childcare workers in the Maintenance stage showing significantly higher total PL scores than those in the Pre-contemplation stage. Structural equation modeling showed an acceptable model fit and reasonable factor loadings, and the path coefficients from childcare workers' PL to support were statistically significant. DISCUSSION: Childcare workers' PL appears to be associated with their experience of sports club participation and stage of change for participation in physical activity. Enhancing childcare workers' PL may aid their support for promoting children's physical activity. CI - Copyright (c) 2026 Honda, Matsunaga, Matsui, Toyama and Suzuki. FAU - Honda, Sho AU - Honda S AD - Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan. FAU - Matsunaga, Misaki AU - Matsunaga M AD - Juntendo Administration for Sports, Health and Medical Sciences, Tokyo, Japan. FAU - Matsui, Masahiro AU - Matsui M AD - Department of Child Psychiatry, Yokohama City University Hospital, Yokohama, Kanagawa, Japan. AD - Faculty of Health and Sports Science, Juntendo University, Chiba, Japan. FAU - Toyama, Kenta AU - Toyama K AD - Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan. FAU - Suzuki, Koya AU - Suzuki K AD - Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan. AD - Juntendo Administration for Sports, Health and Medical Sciences, Tokyo, Japan. AD - Faculty of Health and Sports Science, Juntendo University, Chiba, Japan. AD - Institute of Health and Sports Science & Medicine, Juntendo University, Chiba, Japan. LA - eng PT - Journal Article DEP - 20260413 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Male MH - Female MH - *Exercise MH - Japan MH - *Health Promotion MH - *Child Day Care Centers MH - Child MH - Child, Preschool MH - Adult MH - *Child Care MH - Surveys and Questionnaires PMC - PMC13111194 OTO - NOTNLM OT - Physical Literacy for Life self-assessment tool (PL4L) OT - childcare workers OT - early childhood education OT - physical literacy OT - structural equation modeling OT - support for promoting children's physical activity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author KS declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/04/29 12:25 MHDA- 2026/04/29 12:26 PMCR- 2026/04/13 CRDT- 2026/04/29 04:51 PHST- 2026/02/09 00:00 [received] PHST- 2026/03/09 00:00 [revised] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/04/29 12:26 [medline] PHST- 2026/04/29 12:25 [pubmed] PHST- 2026/04/29 04:51 [entrez] PHST- 2026/04/13 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1807141 [doi] PST - epublish SO - Front Public Health. 2026 Apr 13;14:1807141. doi: 10.3389/fpubh.2026.1807141. eCollection 2026. PMID- 42052024 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Central adiposity outperforms disordered eating behavior in predicting type 2 diabetes risk in young adults: an explainable machine learning approach. PG - 1778156 LID - 10.3389/fpubh.2026.1778156 [doi] LID - 1778156 AB - BACKGROUND: Disordered eating behaviors are often associated with adverse metabolic outcomes, yet their relationship with type 2 diabetes mellitus(T2DM) risk in young adults is less clear. This study aimed to evaluate the impact of disordered eating behaviors on diabetes risk among university students, using both traditional statistical methods and machine learning approaches. METHODS: A total of 1,302 university students participated in this cross-sectional study. Disordered eating behavior was assessed using the Eating Attitudes Test-40 (EAT-40), a validated screening tool for abnormal eating attitudes, while type 2 diabetes risk was estimated using the Finnish Diabetes Risk Score (FINDRISK), a widely used non-invasive instrument designed to estimate the 10-year risk of developing T2DM. Anthropometric measures were recorded according to standardized protocols. Bivariate associations were examined using correlation analysis, while multivariable regression and machine learning models (XGBoost) were applied to determine predictors of diabetes risk. RESULTS: Of the 1,302 participants, 90.8% were classified as low/mild risk, 6.2% as moderate risk, and 3.0% as high/very high risk according to FINDRISK. No significant correlation was found between EAT-40 scores and FINDRISK (r = 0.01, p = 0.755). In multivariable regression, waist-to-height ratio (beta = 1.42 per 0.05 increase, p < 0.001) and body mass index (beta = 0.31, p < 0.001) were the strongest predictors of diabetes risk. Machine learning models, particularly XGBoost (AUROC = 0.87), highlighted waist-to-height ratio as the most influential predictor. CONCLUSION: In young adults, central adiposity specifically waist-to-height ratio was the most significant predictor of T2DM risk, while disordered eating behavior had minimal independent impact. These findings suggest that simple anthropometric measures could be prioritized for early diabetes risk assessment over eating attitude screening. CI - Copyright (c) 2026 Alatas, Arslan, Kurt and Bentli. FAU - Alatas, Hacer AU - Alatas H AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Malatya Turgut Ozal University, Malatya, Turkiye. FAU - Arslan, Nurgul AU - Arslan N AD - Department of Nutrition and Dietetics, Ataturk Faculty of Health Sciences, Dicle University, Diyarbakir, Turkiye. FAU - Kurt, Harun AU - Kurt H AD - Malatya Provincial Health Directorate, Personnel Services Department, Malatya, Turkiye. FAU - Bentli, Serkan AU - Bentli S AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Malatya Turgut Ozal University, Malatya, Turkiye. LA - eng PT - Journal Article DEP - 20260413 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/epidemiology MH - Female MH - Male MH - Young Adult MH - Cross-Sectional Studies MH - *Feeding and Eating Disorders/epidemiology MH - *Machine Learning MH - Risk Factors MH - Risk Assessment MH - *Obesity, Abdominal/epidemiology MH - Adult MH - Universities MH - Students/statistics & numerical data MH - Adolescent MH - *Adiposity PMC - PMC13116002 OTO - NOTNLM OT - FINDRISK OT - disordered eating OT - machine learning OT - type 2 diabetes OT - university students COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/29 12:25 MHDA- 2026/04/29 12:26 PMCR- 2026/04/13 CRDT- 2026/04/29 04:51 PHST- 2025/12/30 00:00 [received] PHST- 2026/03/05 00:00 [revised] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/04/29 12:26 [medline] PHST- 2026/04/29 12:25 [pubmed] PHST- 2026/04/29 04:51 [entrez] PHST- 2026/04/13 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1778156 [doi] PST - epublish SO - Front Public Health. 2026 Apr 13;14:1778156. doi: 10.3389/fpubh.2026.1778156. eCollection 2026. PMID- 42051338 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260429 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Dietary intake, nutritional status and healthcare characteristics of mothers and newborn infants in a prospective cohort study (CHAMP) from a malnutrition-endemic region of Pakistan. PG - 1785862 LID - 10.3389/fnut.2026.1785862 [doi] LID - 1785862 AB - BACKGROUND: Dietary intake, nutritional status, healthcare access, and early-life exposures play a critical role in shaping infant growth and development. Recent evidence suggests that the impact is largely mediated by gut microbiome. The Child Health, Nutrition and Microbiome in Pakistan (the CHAMP study) is a longitudinal cohort study aiming to assess the bidirectional relationship between gut microbiome and infant growth and development in a cohort of children residing in malnutrition endemic areas of Pakistan. OBJECTIVES: The current study report the baseline sociodemographic, dietary, healthcare, and nutritional characteristics of mother-infant dyads participating in the CHAMP study. METHODS: Baseline data were collected from 70 mothers and 72 newborn infants recruited from rural communities in District Swat, Pakistan. Information on household socioeconomic status, maternal dietary intake, antenatal, delivery and postnatal care, infant feeding practices, morbidity, and anthropometric measurements was obtained using validated tools. Descriptive and sex-stratified analyses were conducted. RESULTS: Households were socioeconomically disadvantaged, with low parental education, large family size, and mean household income substantially below the national minimum wage. Maternal utilization and quality of antenatal and postnatal care were suboptimal, including limited completion of recommended antenatal visits. Dietary quality was also poor, and none of the mothers met the recommended minimum dietary diversity for women. Among infants, morbidity was common, with nearly half experiencing diarrheal illness or respiratory infections. Exclusive breastfeeding reported only in 43.1% of infants. Anthropometric assessment revealed evidence of early growth faltering, with 35.4% of infants were low-length-for-age with higher prevalence among females. CONCLUSION: These baseline findings highlight substantial socioeconomic vulnerability, poor maternal diet quality, gaps in maternal and infant healthcare, and early-life undernutrition in this rural Pakistani cohort. The study finding provides foundation for longitudinal analyses examining how these factors interact with gut microbiome development and child growth, informing and cost effective and culturally relevant intervention strategies. CI - Copyright (c) 2026 Shahzad, Saidal, Ismail, Tariq, Melhem, Iqbal, Khattak, Ahmad, Saeed, Ghani, Al Nabhani and Andrews. FAU - Shahzad, Muhammad AU - Shahzad M AD - Faculty of Dentistry, Zarqa University, Zarqa, Jordan. AD - Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan. FAU - Saidal, Ahsan AU - Saidal A AD - KMU Institute of Health Sciences, Swat, Pakistan. FAU - Ismail, Muhammad AU - Ismail M AD - Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan. FAU - Tariq, Kalsoom AU - Tariq K AD - Department of Biochemistry, Khyber Girls Medical College Peshawar, Peshawar, Pakistan. FAU - Melhem, Alaa' Lutfi AU - Melhem AL AD - Faculty of Dentistry, Zarqa University, Zarqa, Jordan. FAU - Iqbal, Khalid AU - Iqbal K AD - Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan. AD - Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology, Bremen, Germany. FAU - Khattak, Maria Ishaq AU - Khattak MI AD - Institute of Public Health and Social Sciences, Khyber Medical University, Peshawar, Pakistan. FAU - Ahmad, Habab Ali AU - Ahmad HA AD - Department of Biological and Health Sciences, Pak-Austria Fachhochschule Institute of Applied Sciences and Technology, Haripur, Pakistan. FAU - Saeed, Muhammad AU - Saeed M AD - Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan. FAU - Ghani, Mustajab AU - Ghani M AD - KMU Institute of Health Sciences, Swat, Pakistan. FAU - Al Nabhani, Ziad AU - Al Nabhani Z AD - Department of Visceral Surgery and Medicine, Bern University Hospital, Bern, Switzerland. AD - Maurice Muller Laboratories, Department for Biomedical Research, University of Bern, Bern, Switzerland. FAU - Andrews, Simon C AU - Andrews SC AD - School of Biological Sciences, Health and Life Sciences Building, University of Reading, Reading, United Kingdom. LA - eng PT - Journal Article DEP - 20260413 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13111393 OTO - NOTNLM OT - birth cohort OT - breastfeeding practices OT - dietary diversity OT - gut microbiome OT - infant growth OT - malnutrition OT - maternal nutrition OT - rural Pakistan COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/29 12:25 MHDA- 2026/04/29 12:26 PMCR- 2026/04/13 CRDT- 2026/04/29 04:44 PHST- 2026/01/12 00:00 [received] PHST- 2026/03/22 00:00 [revised] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/04/29 12:26 [medline] PHST- 2026/04/29 12:25 [pubmed] PHST- 2026/04/29 04:44 [entrez] PHST- 2026/04/13 00:00 [pmc-release] AID - 10.3389/fnut.2026.1785862 [doi] PST - epublish SO - Front Nutr. 2026 Apr 13;13:1785862. doi: 10.3389/fnut.2026.1785862. eCollection 2026. PMID- 42051283 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260429 LR - 20260813 IS - 1735-4587 (Print) IS - 2008-2215 (Electronic) IS - 1735-4587 (Linking) VI - 21 IP - 1 DP - 2026 Jan TI - Demographic and Family Factors Associated with Body Image Dissatisfaction among Adolescents in Tehran. PG - 69-79 LID - 10.18502/ijps.v21i1.20566 [doi] AB - Objective: Body image dissatisfaction is a prevalent concern among adolescents, with potential implications for mental and physical health. Understanding its correlates in diverse cultural contexts, such as Iran, is crucial for developing targeted interventions. This study aimed to investigate the demographic Body Max Index (BMI), gender, etc. socioeconomic status and family structure associated with body image dissatisfaction in a sample of adolescent students in Tehran, Iran. Method : This cross-sectional study included 1,430 students (grades 7, 8 and 9) from randomly selected schools in Tehran. Body image dissatisfaction was assessed using a validated international questionnaire measuring demographics, body perceptions, eating patterns, and family structures. Self-reported weight height values were used to calculate BMI. Misperceived body status was defined as discordance between self-perceived image and actual BMI category. Statistical analyses included chi-square tests, t-tests, and multivariate regression (SPSS v26). Results: A total of 1, 430 participants completed the questionnaires and the mean age of participants was (14.13 +/- 1.2), and 54.8% were females and 785 males (54.9%). The findings revealed that 59.1% of adolescents misperceived their body status. Female gender (OR = 1.5, 95% CI: 1.18-1.90, P = 0.001), lower family SES (socioeconomic status) (OR = 4.27, 95% CI: 1.87-9.74, P < 0.001), higher BMI (OR = 1.09, 95% CI: 1.06-1.12, P < 0.001), and non-biological family structures (OR = 0.79, 95% CI: 0.26-2.3, P = 0.05) were significantly associated with body dissatisfaction. Students living with stepparents or relatives reported lower body satisfaction compared to those living with biological parents. These findings underscore the importance of gender, socioeconomic status, family structure, and BMI as key factors influencing body image dissatisfaction among adolescents. Conclusion: These findings highlight the importance of gender, socioeconomic status and family structure in body dissatisfaction among adolescents. Importantly, these findings reflect the heightened challenges facing youth in the post-COVID-19 era, during which lifestyle changes, increased social media exposure, and altered social interactions have intensified body image concerns. Further research is needed to explore this correlation in more detail and to develop culturally appropriate interventions to promote positive body image. CI - Copyright (c) 2026 Tehran University of Medical Sciences. Published by Tehran University of Medical Sciences. FAU - Mohammadi, Mohammad Reza AU - Mohammadi MR AD - Psychiatry and Psychology Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran. FAU - Zamani, Zahra AU - Zamani Z AD - Community Medicine Specialist, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. FAU - Najafi, Ali AU - Najafi A AD - Medical Library and Information Sciences, Tehran University of Medical Sciences, Tehran, Iran. FAU - Kafami, Zahra AU - Kafami Z AD - Research Centre for Child Psychiatry, University of Turku, Turku, Finland. AD - INVEST Flagship, University of Turku, Turku, Finland. FAU - Yavari, Ali AU - Yavari A AD - Plastic and Reconstructive Surgery Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. FAU - Akhondzadeh, Shahin AU - Akhondzadeh S AD - Psychiatry and Psychology Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran. LA - eng PT - Journal Article PL - Iran TA - Iran J Psychiatry JT - Iranian journal of psychiatry JID - 101302041 PMC - PMC13111964 OTO - NOTNLM OT - Adolescents OT - Body Image OT - Body Mass Index (BMI) OT - Dissatisfaction OT - Eating Disorders COIS- None. EDAT- 2026/04/29 12:25 MHDA- 2026/04/29 12:26 PMCR- 2026/01/01 CRDT- 2026/04/29 04:43 PHST- 2025/07/28 00:00 [received] PHST- 2025/09/28 00:00 [revised] PHST- 2025/10/05 00:00 [accepted] PHST- 2026/04/29 12:26 [medline] PHST- 2026/04/29 12:25 [pubmed] PHST- 2026/04/29 04:43 [entrez] PHST- 2026/01/01 00:00 [pmc-release] AID - IJPS-21-69 [pii] AID - 10.18502/ijps.v21i1.20566 [doi] PST - ppublish SO - Iran J Psychiatry. 2026 Jan;21(1):69-79. doi: 10.18502/ijps.v21i1.20566. PMID- 42050034 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260921 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 5 DP - 2026 Apr 28 TI - Placental hormones, IGF-1, and early-life growth: endocrine links between birth size and infant metabolic programming-a systematic review. LID - 10.1007/s00431-026-06985-5 [doi] LID - 313 AB - The purpose of this study is to systematically review human evidence linking placental hormones and IGF-1 with fetal growth, birth size, and early-life metabolic programming, and to identify disease-specific translational signals relevant to fetal growth restriction, metabolically complicated pregnancy, and extreme prematurity. A systematic review of PubMed and Scopus was performed for human studies published from January 2000 to March 2025. Eligible studies examined placental growth hormone, human placental lactogen, placental IGF-axis markers, or related stress-hormone pathways in relation to birth size, fetal or infant growth, or early metabolic outcomes. Reporting was aligned with PRISMA 2020. Risk of bias was assessed using RoB 2 for randomized trials and ROBINS-I principles for observational studies. Because of substantial clinical and methodological heterogeneity, findings were synthesized narratively. Thirty-seven included studies showed that mid-gestation placental growth hormone had the most consistent positive associations with fetal growth and birth size, whereas early placental growth hormone was less informative. Cord blood IGF-1 was the most reproducible endocrine correlate of birth length and weight. Reduced maternal or placental lactogen signals and lower placental 11beta-HSD2 activity clustered with placental insufficiency and fetal growth restriction, while diabetic pregnancies showed a shift toward adiposity-related outcomes. In extreme prematurity, abrupt loss of placental endocrine support created a translational window in which rhIGF-1/rhIGFBP-3 replacement emerged as the clearest mechanism-based intervention, although current clinical evidence remains preliminary. CONCLUSION: Placental endocrine markers should not be used as standalone screening tools. Their main value at present is mechanistic and translational: combined hormone patterns may refine biological understanding and risk stratification within defined maternal and neonatal disease frameworks, while IGF-1 replacement in extreme prematurity represents the most credible current therapeutic lead. WHAT IS KNOWN: * Placental hormones and IGF-1 are linked with fetal growth, birth size, and neonatal metabolic adaptation, but 45 published evidence is heterogeneous and clinically fragmented. WHAT IS NEW: * This systematic review organizes the human data within fetal growth restriction, diabetic/LGA pregnancy, and extreme prematurity frameworks and identifies translational signals-especially early IGF-1 replacement in extreme prematurity-rather than standalone diagnostic biomarkers. CI - (c) 2026. The Author(s). FAU - Soliman, Ashraf T AU - Soliman AT AUID- ORCID: 0000-0002-9585-9461 AD - Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar. atsoliman56@gmail.com. FAU - Alyafei, Fawzia AU - Alyafei F AD - Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar. FAU - Alaaraj, Nada AU - Alaaraj N AD - Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar. FAU - Ahmed, Shayma AU - Ahmed S AD - Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar. FAU - Hamed, Noor AU - Hamed N AD - Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar. FAU - Elsiddig, Sohair AU - Elsiddig S AD - Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260428 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 67763-96-6 (Insulin-Like Growth Factor I) RN - 0 (Placental Hormones) RN - 0 (Biomarkers) RN - 9035-54-5 (Placental Lactogen) SB - IM MH - Humans MH - Female MH - *Insulin-Like Growth Factor I/metabolism MH - Pregnancy MH - Infant, Newborn MH - *Fetal Development/physiology MH - *Placental Hormones/metabolism MH - *Birth Weight/physiology MH - Developmental Origins of Health and Disease MH - Biomarkers MH - Fetal Growth Retardation MH - Placental Lactogen MH - Placenta/metabolism PMC - PMC13124825 OTO - NOTNLM OT - Fetal growth OT - IGF-1 OT - Metabolic programming OT - Placental hormones OT - Preterm infant OT - Small for gestational age COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/04/29 00:34 MHDA- 2026/04/29 00:35 PMCR- 2026/04/28 CRDT- 2026/04/28 23:30 PHST- 2026/02/12 00:00 [received] PHST- 2026/04/18 00:00 [accepted] PHST- 2026/04/09 00:00 [revised] PHST- 2026/04/29 00:35 [medline] PHST- 2026/04/29 00:34 [pubmed] PHST- 2026/04/28 23:30 [entrez] PHST- 2026/04/28 00:00 [pmc-release] AID - 10.1007/s00431-026-06985-5 [pii] AID - 6985 [pii] AID - 10.1007/s00431-026-06985-5 [doi] PST - epublish SO - Eur J Pediatr. 2026 Apr 28;185(5):313. doi: 10.1007/s00431-026-06985-5. PMID- 42049579 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260802 IS - 1871-403X (Print) IS - 1871-403X (Linking) VI - 20 IP - 3 DP - 2026 May-Jun TI - Is there a relationship between culinary skills and overweight/ obesity across life stages? A systematic review. PG - 168-175 LID - S1871-403X(26)00038-4 [pii] LID - 10.1016/j.orcp.2026.04.004 [doi] AB - INTRODUCTION: Obesity is a public health problem that affects millions of people worldwide, but its relationship with culinary skills has not yet been elucidated. This systematic review investigated the relationship between culinary skills and the prevalence of overweight and obesity among adolescents, adults, and older adults. We hypothesize that low cooking skills are associated with a higher prevalence of overweight and obesity across different life stages. METHODS: We searched the PubMed, Embase, and Web of Science databases from July to August 2024. The risk of bias assessment was performed using the Joanna Briggs Institute (JBI) tools. RESULTS: Five studies (three cross-sectional and two cohort) were included, totaling 53,557 subjects from Brazil, Italy, Canada, Japan, and France. The studies used body mass index or waist circumference to assess overweight and obesity. Culinary skills were evaluated using various non-standardized questionnaires covering knowledge, culinary techniques, cooking frequency, and ingredients used. One cohort study reported a negative association between culinary skills and overweight/obesity in adults. Conversely, two cross-sectional and cohort studies identified a positive association among adolescents and adults. CONCLUSIONS: The relationship between culinary skills and overweight/obesity remains inconclusive across the studies. We encourage future research to understand this relationship across different life stages better and to validate appropriate tools for evaluating culinary skills. CI - Copyright (c) 2026 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved. FAU - de Morais, Rafaela Nogueira Gomes AU - de Morais RNG AD - Department of Nutrition and Health, Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil. Electronic address: rafaela.morais@ufv.br. FAU - Ribeiro, Guilherme Jose Silva AU - Ribeiro GJS AD - Department of Nutrition and Health, Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil. Electronic address: guilherme.j.ribeiro@ufv.br. FAU - de Novaes, Juliana Farias AU - de Novaes JF AD - Department of Nutrition and Health, Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil. Electronic address: jnovaes@ufv.br. FAU - Rocha, Daniela Mayumi Usuda Prado AU - Rocha DMUP AD - Laboratory of Clinical Analysis and Genomics, Department of Nutrition and Health, Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil; Laboratory of Energy Metabolism and Body Composition, Department of Nutrition and Health, Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil; Institute of Public Policies and Sustainable Development, Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil. Electronic address: mayumi.dani@gmail.com. FAU - Kravchychyn, Ana Claudia Pelissari AU - Kravchychyn ACP AD - Laboratory of Clinical Analysis and Genomics, Department of Nutrition and Health, Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil; Laboratory of Energy Metabolism and Body Composition, Department of Nutrition and Health, Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil. Electronic address: ana.pelissari@ufv.br. FAU - Hermsdorff, Helen Hermana Miranda AU - Hermsdorff HHM AD - Laboratory of Clinical Analysis and Genomics, Department of Nutrition and Health, Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil; Laboratory of Energy Metabolism and Body Composition, Department of Nutrition and Health, Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil; Institute of Public Policies and Sustainable Development, Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil. Electronic address: helenhermana@ufv.br. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Systematic Review DEP - 20260428 PL - Netherlands TA - Obes Res Clin Pract JT - Obesity research & clinical practice JID - 101303911 SB - IM MH - Humans MH - *Overweight/epidemiology MH - *Obesity/epidemiology MH - *Cooking/methods MH - Adolescent MH - Body Mass Index MH - Adult MH - Cross-Sectional Studies MH - Prevalence MH - Female MH - Aged MH - Male OTO - NOTNLM OT - Cooking OT - Culinary nutrition OT - Dietitians OT - Health education OT - Overweight COIS- Declaration of Competing Interest The authors declare no conflict of interest. EDAT- 2026/04/29 00:34 MHDA- 2026/06/13 00:39 CRDT- 2026/04/28 21:52 PHST- 2025/01/27 00:00 [received] PHST- 2026/02/01 00:00 [revised] PHST- 2026/04/19 00:00 [accepted] PHST- 2026/06/13 00:39 [medline] PHST- 2026/04/29 00:34 [pubmed] PHST- 2026/04/28 21:52 [entrez] AID - S1871-403X(26)00038-4 [pii] AID - 10.1016/j.orcp.2026.04.004 [doi] PST - ppublish SO - Obes Res Clin Pract. 2026 May-Jun;20(3):168-175. doi: 10.1016/j.orcp.2026.04.004. Epub 2026 Apr 28. PMID- 42048665 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260617 IS - 2191-0251 (Electronic) IS - 0334-018X (Linking) VI - 39 IP - 6 DP - 2026 Jun 24 TI - Predicting abdominal obesity in children and adolescents via machine learning: a longitudinal cohort study. PG - 545-555 LID - 10.1515/jpem-2025-0321 [doi] AB - OBJECTIVES: This study aimed to construct and verify machine learning (ML) models to predict long-term abdominal obesity (AO) risk in children and adolescents. METHODS: We trained and externally validated ML models to predict pediatric AO 4-5 years later using a publicly available longitudinal cohort. The body roundness index (BRI) was used as the diagnostic criterion for AO. The training/internal-validation cohort comprised 635 youths (2011-->2015); an independent 2006-->2011 cohort (n=456) provided external validation. After screening 25 routine variables and multiple imputation, four ML algorithms were evaluated by area under the receiver operating characteristic curve (AUC), sensitivity, specificity and F1-score across all three datasets. RESULTS: Among 635 children and adolescents in the raw-training set followed for four years, 164 (25.83 %) developed AO. Univariable analysis identified 12 significant baseline predictors (p<0.1); multivariable logistic regression (LR) retained five independent factors: body mass index (BMI), height, carbohydrate intake, reading/writing activity and urban residence. Four machine-learning algorithms were trained and validated; LR demonstrated the most stable performance across training (AUC=0.705), internal validation (AUC=0.742) and external validation (AUC=0.667) datasets. CONCLUSIONS: The LR model stands out as a potential tool in predicting long-term AO risk in children and adolescents. CI - (c) 2026 Walter de Gruyter GmbH, Berlin/Boston. FAU - Ding, Xiaoyan AU - Ding X AD - Pediatric Department, Beijing Anzhen Nanchong Hospital, Capital Medical University & Nanchong Central Hospital, Nanchong, China. FAU - Fang, Xiao AU - Fang X AUID- ORCID: 0009-0005-7358-1349 AD - 85407 National Science Library (Chengdu), Chinese Academy of Sciences , Chengdu, China. FAU - Bai, Jing AU - Bai J AD - Pediatric Department, Beijing Anzhen Nanchong Hospital, Capital Medical University & Nanchong Central Hospital, Nanchong, China. FAU - Liu, Rui AU - Liu R AD - Pediatric Department, Beijing Anzhen Nanchong Hospital, Capital Medical University & Nanchong Central Hospital, Nanchong, China. FAU - Ma, Can AU - Ma C AD - School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China. LA - eng PT - Journal Article DEP - 20260427 PL - Germany TA - J Pediatr Endocrinol Metab JT - Journal of pediatric endocrinology & metabolism : JPEM JID - 9508900 SB - IM MH - Humans MH - Child MH - Adolescent MH - *Obesity, Abdominal/diagnosis/epidemiology MH - *Machine Learning MH - Female MH - Longitudinal Studies MH - Male MH - *Body Mass Index MH - Predictive Learning Models MH - Prognosis MH - Prediction Algorithms MH - Follow-Up Studies MH - Risk Factors MH - Classification Algorithms MH - ROC Curve MH - *Pediatric Obesity/diagnosis/epidemiology MH - Algorithms OTO - NOTNLM OT - abdominal obesity OT - adolescent OT - child OT - logistic models OT - machine learning EDAT- 2026/04/28 18:33 MHDA- 2026/06/13 00:38 CRDT- 2026/04/28 17:13 PHST- 2025/06/06 00:00 [received] PHST- 2026/03/12 00:00 [accepted] PHST- 2026/06/13 00:38 [medline] PHST- 2026/04/28 18:33 [pubmed] PHST- 2026/04/28 17:13 [entrez] AID - jpem-2025-0321 [pii] AID - 10.1515/jpem-2025-0321 [doi] PST - epublish SO - J Pediatr Endocrinol Metab. 2026 Apr 27;39(6):545-555. doi: 10.1515/jpem-2025-0321. Print 2026 Jun 24. PMID- 42048577 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260715 IS - 1613-9860 (Electronic) IS - 1613-9860 (Linking) VI - 16 IP - 1 DP - 2026 Jan 7 TI - Using EPIS and facilitation to support delivery of classroom-based physical activity interventions: a case study. LID - ibag005 [pii] LID - 10.1093/tbm/ibag005 [doi] AB - BACKGROUND: Youth physical inactivity is a major public health concern, particularly in schools serving socioeconomically disadvantaged children. Classroom-based physical activity (PA) interventions offer structured, equitable opportunities for movement, but adoption-fidelity gaps persist. Implementation science frameworks can support schools in aligning interventions with local context and sustaining delivery. PURPOSE: This study examined the feasibility of using the Exploration, Preparation, Implementation, and Sustainment (EPIS) framework, paired with facilitation by trained regional school health coordinators, to guide classroom PA implementation in a Michigan elementary school. METHODS: An EPIS-aligned implementation guide was developed and refined through a two-phase process to ensure theoretical grounding and practical applicability. Six coordinators were trained and evaluated the training using validated measures of acceptability, appropriateness, and feasibility. One coordinator facilitated InPACT implementation at a single school over 18 months, supporting pre-implementation, rollout, and early sustainment. Implementation was documented using the Hexagon Tool, RE-AIM, Plan-Do-Study-Act cycles, and routine administrative data. RESULTS: Coordinators rated the training highly on all measures. In the pilot school, teachers delivered an average of three PA breaks per day, with lower-elementary classrooms averaging four and upper-elementary classrooms averaging two. Fidelity was supported through structured ramp-up, teacher training, technical assistance, and classroom tracking. Integration into school systems helped to fill gaps in the school district wellness policy. Behavioral referral data indicated a 34% reduction in minor classroom incidents over the first year of implementation. CONCLUSIONS: EPIS-guided implementation with facilitation is feasible for supporting adoption, fidelity, and early sustainment of classroom PA. Structured pre-implementation planning, phase-specific support, and alignment with school priorities are critical. Multi-site studies are needed to examine grade-specific strategies, fidelity variability, and long-term sustainment. CI - (c) Society of Behavioral Medicine 2026. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Hasson, Rebecca E AU - Hasson RE AUID- ORCID: 0000-0003-4526-2656 AD - University of Michigan School of Kinesiology, Ann Arbor, MI, United States. FAU - Dros, Danielle AU - Dros D AD - Washtenaw Intermediate School District, Ann Arbor, MI, United States. FAU - Roy-Borland, Heidi AU - Roy-Borland H AD - Whitmore Lake Elementary School, Whitmore Lake, MI, United States. FAU - Eisman, Andria B AU - Eisman AB AD - Center for Health and Community Impact, Wayne State University College of Education, Detroit, MI, United States. FAU - Friday, Penelope J AU - Friday PJ AD - University of Michigan School of Kinesiology, Ann Arbor, MI, United States. FAU - Schwartz, Anna AU - Schwartz A AD - University of Michigan School of Kinesiology, Ann Arbor, MI, United States. FAU - Abbas, Hala I AU - Abbas HI AD - University of Michigan School of Kinesiology, Ann Arbor, MI, United States. LA - eng GR - R-2204-150254/Michigan Health Endowment Fund/ PT - Journal Article PL - England TA - Transl Behav Med JT - Translational behavioral medicine JID - 101554668 SB - IM MH - Humans MH - Schools MH - *Exercise MH - *Health Promotion/methods MH - Child MH - *School Health Services MH - Implementation Science MH - Michigan MH - Feasibility Studies OAB - Many children do not get enough physical activity (PA) during school, especially in under-resourced settings. This inactivity can negatively affect physical, emotional, and cognitive development. We tested whether the EPIS framework-Exploration, Preparation, Implementation, and Sustainment-combined with facilitation provided by trained regional school health coordinators, could help schools adopt and maintain InPACT (Interrupting Prolonged Sitting with Activity), a classroom-based PA intervention. Facilitation means hands-on support for teachers and leaders, including strategic thinking and problem-solving, and guidance on using EPIS-aligned tools. InPACT encourages teachers to provide short activity breaks throughout the school day. Six coordinators were trained to use the guide combining EPIS with facilitation. One elementary school piloted the approach for over 18 months. Teachers delivered an average of three activity breaks daily, with younger grades averaging more than older ones. Teachers and administrators also reported improved student behavior, and the school embedded activity breaks into staff onboarding to ensure long-term use. Our findings show that EPIS with facilitation can help schools plan, deliver, monitor, and sustain classroom activity breaks. Larger studies are needed to strengthen evidence and support wider adoption. OABL- eng OTO - NOTNLM OT - exercise OT - health promotion OT - implementation science OT - program sustainability OT - schools EDAT- 2026/04/28 18:33 MHDA- 2026/04/28 18:34 CRDT- 2026/04/28 15:13 PHST- 2025/09/14 00:00 [received] PHST- 2025/12/29 00:00 [revised] PHST- 2026/01/22 00:00 [accepted] PHST- 2026/04/28 18:34 [medline] PHST- 2026/04/28 18:33 [pubmed] PHST- 2026/04/28 15:13 [entrez] AID - 8664265 [pii] AID - 10.1093/tbm/ibag005 [doi] PST - ppublish SO - Transl Behav Med. 2026 Jan 7;16(1):ibag005. doi: 10.1093/tbm/ibag005. PMID- 42047227 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2047-7163 (Electronic) IS - 0036-8504 (Print) IS - 0036-8504 (Linking) VI - 109 IP - 2 DP - 2026 Apr-Jun TI - Does three-dimensional facial morphology relate to risk of sleep-disordered breathing in children? A cross-sectional study. PG - 368504261446472 LID - 10.1177/00368504261446472 [doi] LID - 00368504261446472 AB - ObjectiveTo assess the feasibility of three-dimensional (3D) stereophotogrammetry as a tool in pediatric outpatient assessment, in exploring associations between facial morphometric parameters of children aged 2-17 years, and their risk of sleep-disordered breathing (SDB) as evidenced by their Pediatric Sleep Questionnaire (PSQ) score.MethodsA cross-sectional study of 180 pediatric patients (aged 2-17 years) recruited consecutively from a tertiary pediatric otolaryngology clinic. 3D facial images were acquired using stereophotogrammetry, and patients' SDB risk was evaluated using the validated PSQ. Linear regression models assessed associations between PSQ scores and demographic and facial morphometric variables. Geometric morphometric (GMM) analysis was performed to assess differences in facial morphology between subjects at high and low risk for SDB.Results33.9% of patients scored at high risk for SDB. No statistically significant associations were found between PSQ score and any 3D facial morphometric parameter. PSQ score was not associated with sex, age, agexsex interaction, or body mass index. Geometric morphometric analysis found no difference in facial shape between those at high risk for SDB and those at lower risk.ConclusionsStereophotogrammetry may be successfully applied in a specialist pediatric outpatient clinic as a non-invasive and low-resource method for measuring 3D facial features. No linear or angular measurements assessed in this study were found to have a strong correlation with PSQ score. These findings suggest that 3D external facial soft-tissue measures may not add discriminatory value beyond symptom-based screening in this tertiary clinic setting, and that facial morphology alone is unlikely to be a sufficient screening tool for pediatric SDB. Screening should primarily be based on patient signs and symptoms, and consideration of internal anatomical factors. FAU - Pliska, Benjamin T AU - Pliska BT AUID- ORCID: 0000-0002-8935-7203 AD - Division of Orthodontics, Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada. RINGGOLD: 8166 FAU - Wu, Felix Y H AU - Wu FYH AD - Division of Orthodontics, Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada. RINGGOLD: 8166 FAU - Liu, Alice Q AU - Liu AQ AD - Division of Pediatric Otolaryngology-Head & Neck Surgery, BC Children's Hospital, Vancouver, BC, Canada. FAU - Vora, Siddharth R AU - Vora SR AD - Division of Orthodontics, Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada. RINGGOLD: 8166 FAU - Chadha, Neil K AU - Chadha NK AD - Division of Pediatric Otolaryngology-Head & Neck Surgery, BC Children's Hospital, Vancouver, BC, Canada. LA - eng PT - Journal Article DEP - 20260428 PL - England TA - Sci Prog JT - Science progress JID - 0411361 SB - IM MH - Humans MH - Child MH - Cross-Sectional Studies MH - Female MH - Male MH - Child, Preschool MH - Adolescent MH - *Sleep Apnea Syndromes/diagnosis/pathology MH - *Face/anatomy & histology MH - Photogrammetry/methods MH - *Imaging, Three-Dimensional MH - Risk Factors MH - Surveys and Questionnaires PMC - PMC13145041 OTO - NOTNLM OT - craniofacial morphology OT - geometric morphometrics OT - obstructive sleep apnea OT - pediatrics OT - sleep-disordered breathing OT - snoring OT - stereophotogrammetry COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/04/28 17:38 MHDA- 2026/04/28 17:39 PMCR- 2026/04/28 CRDT- 2026/04/28 06:23 PHST- 2026/04/28 17:39 [medline] PHST- 2026/04/28 17:38 [pubmed] PHST- 2026/04/28 06:23 [entrez] PHST- 2026/04/28 00:00 [pmc-release] AID - 10.1177_00368504261446472 [pii] AID - 10.1177/00368504261446472 [doi] PST - ppublish SO - Sci Prog. 2026 Apr-Jun;109(2):368504261446472. doi: 10.1177/00368504261446472. Epub 2026 Apr 28. PMID- 42044871 OWN - NLM STAT- MEDLINE DCOM- 20260610 LR - 20260610 IS - 2191-0251 (Electronic) IS - 0334-018X (Linking) VI - 39 IP - 5 DP - 2026 May 26 TI - Puberty promoting low dose testosterone treatment improved wellbeing and emotional state in boys with self-limited delayed puberty. PG - 425-431 LID - 10.1515/jpem-2025-0719 [doi] AB - OBJECTIVES: To evaluate changes in health-related quality of life in boys aged 14-16 years with delayed or slowly progressing puberty before and after low-dose testosterone treatment. Delayed puberty can cause short stature, emotional distress, and social challenges. Testosterone therapy promotes growth and masculinization, but its impact on quality of life remains poorly understood. Few studies have assessed psychosocial outcomes using validated instruments. METHODS: Twenty-seven boys enrolled in the Pubertal Replacement in Boys Study and were randomized to testosterone enanthate (75 mg/month for 6 months; n=12) (n=12) or testosterone undecanoate (n=12) (250 mg every 3 months; n=15). Standardized self-report questionnaires assessed generic quality of life (primary outcome), stature-specific quality of life, depressive symptoms, and enjoyment of physical activity. Assessments were conducted at baseline, 6 months, and 12 months. RESULTS: Twenty-six boys completed the study. Both regimens induced pubertal progression and a mean growth of 9.3 cm 12 months after start of replacement treatment. Significant improvements were observed in generic quality of life and depressive symptoms, with early gains sustained through 12 months. No changes were detected in stature-specific quality of life or enjoyment of physical activity. No statistical differences were found between treatment groups at 6 or 12 months. Exploratory analyses suggested that baseline testosterone serum levels were modestly associated with changes in social functioning, whereas later serum levels showed no such relationship. CONCLUSIONS: Low-dose testosterone therapy improves generic quality of life and mood in boys with self-limited delayed puberty, likely reflecting successful pubertal progression. These findings highlight the importance of psychosocial outcomes as indicators of treatment success, beyond growth acceleration, and support structured follow-up to address the emotional needs of adolescents with delayed puberty. CI - (c) 2026 the author(s), published by De Gruyter, Berlin/Boston. FAU - Osterbrand, Martin AU - Osterbrand M AUID- ORCID: 0000-0003-4684-1983 AD - Department of Paediatrics, Gothenburg Paediatric Growth Research Centre, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. AD - Nal Uddevalla Sjukvarden (NU) Hospital Group, Trollhattan, Sweden. FAU - Fors, Hans AU - Fors H AUID- ORCID: 0009-0006-2252-8545 AD - Department of Paediatrics, Gothenburg Paediatric Growth Research Centre, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. AD - Gothenburg Department of Paediatrics, Endocrine Division, Queen Silvia Children's Hospital, Gothenburg, Sweden. FAU - Norjavaara, Ensio AU - Norjavaara E AUID- ORCID: 0000-0003-0415-4843 AD - Department of Paediatrics, Gothenburg Paediatric Growth Research Centre, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. AD - Gothenburg Department of Paediatrics, Endocrine Division, Queen Silvia Children's Hospital, Gothenburg, Sweden. FAU - Chaplin, John Eric AU - Chaplin JE AUID- ORCID: 0000-0001-8128-4225 AD - Department of Paediatrics, Gothenburg Paediatric Growth Research Centre, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260424 PL - Germany TA - J Pediatr Endocrinol Metab JT - Journal of pediatric endocrinology & metabolism : JPEM JID - 9508900 RN - 3XMK78S47O (Testosterone) RN - 7Z6522T8N9 (testosterone enanthate) RN - H16A5VCT9C (testosterone undecanoate) RN - 0 (Androgens) SB - IM MH - Humans MH - Male MH - Adolescent MH - *Puberty, Delayed/drug therapy/psychology MH - *Testosterone/analogs & derivatives/administration & dosage/therapeutic use MH - *Quality of Life MH - *Emotions/drug effects MH - *Puberty/drug effects MH - Follow-Up Studies MH - Prognosis MH - *Androgens/administration & dosage MH - *Hormone Replacement Therapy OTO - NOTNLM OT - Kidscreen OT - delayed puberty OT - quality of life OT - testosterone EDAT- 2026/04/28 00:33 MHDA- 2026/06/10 11:43 CRDT- 2026/04/27 19:14 PHST- 2025/12/17 00:00 [received] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/06/10 11:43 [medline] PHST- 2026/04/28 00:33 [pubmed] PHST- 2026/04/27 19:14 [entrez] AID - jpem-2025-0719 [pii] AID - 10.1515/jpem-2025-0719 [doi] PST - epublish SO - J Pediatr Endocrinol Metab. 2026 Apr 24;39(5):425-431. doi: 10.1515/jpem-2025-0719. Print 2026 May 26. PMID- 42044770 OWN - NLM STAT- MEDLINE DCOM- 20260606 LR - 20260726 IS - 1938-3207 (Electronic) IS - 0002-9165 (Print) IS - 0002-9165 (Linking) VI - 123 IP - 6 DP - 2026 Jun TI - Differential associations between menstrual blood loss scores and iron status in East Asian and Northern European individuals: findings from a cross-sectional analysis of the Iron Genes in East Asian and Northern European Adults Study (FeGenes) cohort. PG - 101326 LID - S0002-9165(26)00135-8 [pii] LID - 10.1016/j.ajcnut.2026.101326 [doi] LID - 101326 AB - BACKGROUND: Healthy adult females of East Asian (EA) ancestry have been reported to have higher iron (Fe) stores and Fe absorption and alterations in Fe regulatory hormones when compared with adult females of Northern European (NE) ancestry. OBJECTIVES: This cross-sectional study collected data on menstrual characteristics among adult females of genetically confirmed EA or NE ancestry and evaluated the potential impact of this factor on Fe status. METHODS: Data were obtained from premenopausal females aged 18 to 50 y [BMI (in kg/m(2)) 18-30] who were enrolled in the FeGenes study, which recruited healthy individuals of genetically confirmed EA or NE ancestry. Data on age at menarche, cycle frequency, menstrual bleeding duration, and use of menstrual products were collected from self-reported questionnaires, and menstrual blood loss (MBL) scores were calculated. Fe status was assessed through serum ferritin (microgram per liter), hepcidin (nanograms per milliliter), soluble transferrin (TF) receptor (milligram per liter), TF (milligram per deciliter), and calculated total body Fe (milligrams per kilogram). Group comparisons and associations with Fe status biomarkers were examined. RESULTS: EA females had an earlier median age at menarche [EA: 12.0 (IQR: 11.0, 13.0) y; NE: 13.0 (IQR: 12.0, 13.3) y; P = 0.002] and a higher MBL score [EA: 24.0 (IQR:17.5, 31.5); NE: 16.0 (IQR: 10.5, 27.9); P < 0.001] than NE females. In NE individuals, a higher MBL score was significantly associated with lower log-transformed serum ferritin (beta: ‒0.01; SE: 0.005; P = 0.004), total body Fe (beta: ‒0.06; SE: 0.02; P = 0.002), and higher log-transformed soluble TF receptor (beta: 0.005; SE: 0.001; P = 0.002). No associations between MBL score and Fe status were evident in EA females. CONCLUSIONS: Higher MBL scores are associated with lower Fe status in NE but not EA females. Greater attention and validated metrics are needed to evaluate MBL and better quantify Fe needs in reproductive-aged females. This trial was registered at clinicaltrials.gov as NCT04198545. CI - Copyright (c) 2026 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Lee, Min-Ruei AU - Lee MR AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Barad, Alexa AU - Barad A AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Bender, Erica AU - Bender E AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Thompson, Jennifer AU - Thompson J AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Gu, Zhenglong AU - Gu Z AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Pressman, Eva K AU - Pressman EK AD - Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, NY, United States. FAU - O'Brien, Kimberly O AU - O'Brien KO AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. Electronic address: koo4@cornell.edu. LA - eng SI - ClinicalTrials.gov/NCT04198545 GR - R01 DK122216/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20260425 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 RN - 9007-73-2 (Ferritins) RN - 0 (Hepcidins) RN - E1UOL152H7 (Iron) RN - 0 (Receptors, Transferrin) RN - 0 (Transferrin) SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Middle Aged MH - Young Adult MH - Cohort Studies MH - Cross-Sectional Studies MH - Ferritins/blood MH - Hepcidins/blood MH - *Iron/blood/metabolism MH - *Menarche MH - Menorrhagia/blood MH - *Menstruation MH - Receptors, Transferrin/blood MH - Transferrin/metabolism MH - White People MH - East Asian People PMC - PMC13265119 MID - NIHMS2178913 OTO - NOTNLM OT - East Asian OT - Northern European OT - age at menarche OT - ancestry OT - iron deficiency OT - menstrual blood loss OT - serum ferritin OT - total body iron COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/04/28 00:33 MHDA- 2026/06/06 18:42 PMCR- 2027/04/25 CRDT- 2026/04/27 19:13 PHST- 2025/12/10 00:00 [received] PHST- 2026/03/27 00:00 [revised] PHST- 2026/04/20 00:00 [accepted] PHST- 2026/06/06 18:42 [medline] PHST- 2026/04/28 00:33 [pubmed] PHST- 2026/04/27 19:13 [entrez] PHST- 2027/04/25 00:00 [pmc-release] AID - S0002-9165(26)00135-8 [pii] AID - 101326 [pii] AID - 10.1016/j.ajcnut.2026.101326 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Jun;123(6):101326. doi: 10.1016/j.ajcnut.2026.101326. Epub 2026 Apr 25. PMID- 42044742 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20260916 IS - 2212-2672 (Print) IS - 2212-2672 (Linking) VI - 126 IP - 9 DP - 2026 Sep TI - Application of the Total Nutrient Index as a Precision Nutrition Tool to Address Dietary Recommendations Across the Life Course. PG - 156368 LID - S2212-2672(26)00083-3 [pii] LID - 10.1016/j.jand.2026.156368 [doi] AB - BACKGROUND: Indexes are a standardized tool for assessing dietary exposures from foods/beverages (F&B) and have recently been extended to include dietary supplements (DS). The Total Nutrient Index (TNI) (F&B + DS) and the Food Nutrient Index (FNI) (F&B only) were developed to assess micronutrient intakes relative to Dietary Reference Intakes for micronutrients and were previously examined for relative validity among US adults. OBJECTIVE: This study examined the micronutrient quality (ie, TNI and FNI) of the diet across all age groups and compared TNI and FNI total and component scores with Healthy Eating Index 2020 scores among the US population. This analysis also sought to demonstrate the flexibility of the TNI and FNI frameworks across the life course. DESIGN: A nationally representative, cross-sectional analysis of the 2015-2020 National Health and Nutrition Examination Survey demographic, dietary, and dietary supplement data (ie, 24-hour dietary recall and DS inventory) was conducted among the US population. PARTICIPANTS AND SETTING: This study included US adults and children (aged 1 year and older; n = 19 903) who participated in the 2015-2020 National Health and Nutrition Examination Survey. MAIN OUTCOMES: The main outcome measures were TNI and FNI total and component scores (range = 0 to 100) overall and by age group, with higher scores indicating greater adherence to the Dietary Reference Intakes. STATISTICAL ANALYSES PERFORMED: TNI and FNI scores were calculated via the simple algorithm method, for 11 age group-dependent micronutrients (calcium, choline, magnesium, phosphorus, potassium, and vitamins A, B12, C, D, E, and K), and compared with Healthy Eating Index 2020 scores. RESULTS: Americans scored 72 out of 100 on TNI, but scores varied by age and were higher for the TNI than FNI ( approximately 3 to 11 points.). Younger children (aged 1 to 3 years, TNI = 87; aged 4 to 8 years, TNI = 82) and older adults (aged 71 years and older, TNI = 77) exhibited higher TNI scores than other ages, due to higher calcium, magnesium, and vitamins A, C, and B12 intake. Healthy Eating Index 2020 total scores were low (52) overall and followed similar scoring trajectories by age group as the TNI and FNI. CONCLUSIONS: Evaluating total dietary exposures is important, considering the differential intake patterns from F&B, vs those with DS. Given low Dietary Reference Intakes adherence for some nutrients across the life span, these findings warrant improved diet quality and micronutrient density for many, to optimize nutrition and reduce diet-related chronic disease risk among Americans. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Cowan-Pyle, Alexandra E AU - Cowan-Pyle AE AD - Institute for Connecting Nutrition and Health, Florida State University, Tallahassee, Florida; Department of Behavioral Sciences and Social Medicine, College of Medicine, Florida State University, Tallahassee, Florida. Electronic address: aecowan@fsu.edu. FAU - Tooze, Janet A AU - Tooze JA AD - Department of Biostatistics and Data Science, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina. FAU - Reynolds, Lindsay M AU - Reynolds LM AD - Department of Epidemiology and Prevention, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina. FAU - Gahche, Jaime J AU - Gahche JJ AD - Office of Dietary Supplements, National Institutes of Health, Bethesda, Maryland. FAU - Dwyer, Johanna T AU - Dwyer JT AD - Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts. FAU - Mitchell, Diane C AU - Mitchell DC AD - Institute for Advancing Health Through Agriculture, Texas A&M AgriLife Research, Texas A&M University System, College Station, Texas. FAU - Carroll, Raymond J AU - Carroll RJ AD - Department of Statistics, Texas A&M University, College Station, Texas. FAU - Mallick, Bani K AU - Mallick BK AD - Department of Statistics, Texas A&M University, College Station, Texas. FAU - Bailey, Regan L AU - Bailey RL AD - Institute for Connecting Nutrition and Health, Florida State University, Tallahassee, Florida; Department of Behavioral Sciences and Social Medicine, College of Medicine, Florida State University, Tallahassee, Florida. LA - eng GR - U01 CA215834/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20260425 PL - United States TA - J Acad Nutr Diet JT - Journal of the Academy of Nutrition and Dietetics JID - 101573920 RN - 0 (Micronutrients) SB - IM MH - Humans MH - Nutrition Surveys MH - Female MH - Male MH - Adult MH - Child, Preschool MH - Child MH - *Micronutrients/administration & dosage/analysis MH - Adolescent MH - Cross-Sectional Studies MH - Infant MH - Young Adult MH - *Recommended Dietary Allowances MH - Middle Aged MH - United States MH - Aged MH - Dietary Supplements MH - *Nutrition Assessment MH - *Diet, Healthy/statistics & numerical data MH - *Diet/standards MH - Nutrition Policy PMC - PMC13575888 MID - NIHMS2205793 OTO - NOTNLM OT - Dietary Reference Intakes OT - Dietary Supplements OT - Micronutrients OT - NHANES OT - Total Nutrient Index COIS- STATEMENT OF POTENTIAL CONFLICT OF INTEREST Unrelated to this submission, A. E. Cowan-Pyle is a member of the Journal of the Academy of Nutrition and Dietetics Board of Editors, has previously served as a consultant to the National Pork Board, Think Healthy Group, and the General Mills Bell Institute, and has received travel support from the Council of Responsible Nutrition. R. L. Bailey has served as a consultant to the National Institutes of Health Office of Dietary Supplements, Nestle, the General Mills Bell Institute, RTI International, Think Healthy Group, and Nutrition Impact; is a former trustee of the International Food Information Council; and is a former board member of the International Life Sciences Institute-North America. She has received travel support to present her research on dietary supplements and is a former member of the Journal of Nutrition editorial board. J. T. Dwyer owns stock in several food and drug companies. Unrelated to this publication she serves on the scientific advisory committee of the McCormick Science Institute, the Mushroom Council, and served in the past on scientific advisory boards of Bay State Milling, the Singapore Institute of Food and Biotechnology Innovation and Nestle. She serves as an unpaid advisor to the Institute for the Advancement of Food and Nutrition Sciences Low Calorie Sweetener Committee and on the Bioactives Committee of the International Life Sciences Institute US-Canada Research Program and is editor of Nutrition Today. EDAT- 2026/04/28 00:35 MHDA- 2026/08/19 23:42 PMCR- 2026/09/15 CRDT- 2026/04/27 19:12 PHST- 2025/10/22 00:00 [received] PHST- 2026/03/13 00:00 [revised] PHST- 2026/04/20 00:00 [accepted] PHST- 2026/08/19 23:42 [medline] PHST- 2026/04/28 00:35 [pubmed] PHST- 2026/04/27 19:12 [entrez] PHST- 2026/09/15 00:00 [pmc-release] AID - S2212-2672(26)00083-3 [pii] AID - 10.1016/j.jand.2026.156368 [doi] PST - ppublish SO - J Acad Nutr Diet. 2026 Sep;126(9):156368. doi: 10.1016/j.jand.2026.156368. Epub 2026 Apr 25. PMID- 42044293 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260828 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 Apr 27 TI - Comparing Perceptions of ChatGPT Use in Health Attitude Contexts Among Users and Nonusers: Cross-Sectional Study. PG - e79276 LID - 10.2196/79276 [doi] LID - e79276 AB - BACKGROUND: In light of the growing use of artificial intelligence (AI) in health care, individuals' access to and use of health information are transforming. ChatGPT, an AI chatbot, provides immediate responses to health queries, with the potential to influence health-related attitudes, thereby raising concerns related to privacy, reliability, and security. OBJECTIVE: This study aimed to investigate the perceived usefulness, risks, anxiety, and social influence of ChatGPT on health attitudes among users and nonusers in Saudi Arabia. METHODS: A cross-sectional study was conducted using an online survey based on a validated tool. In total, 337 participants aged 18 years and older responded to questions assessing their perceptions of ChatGPT on health-related attitudes. RESULTS: Data showed that 76.1% (194/255) of the respondents used ChatGPT, with the majority being younger and more highly educated. The main uses for health-related purposes were health education (43/194, 22.2%) and physical activity guidance (31/194, 16%). The analysis showed that users considered ChatGPT useful for health-related decisions, with 45.9% (89/194) finding it easy to learn and use, but concerns about privacy (106/194, 54.7%) and reliability (87/194, 44.9%) remained. Among nonusers, security risks (39/61, 63.9%) were the major barrier to using AI-based tools for health purposes, and 68.9% (42/61) found such tools attractive and engaging. There were no statistically significant differences between users and nonusers across all examined sociodemographic characteristics (P>.05). CONCLUSIONS: The study established the potential of ChatGPT in improving health decision-making and revealed cultural, privacy, and trust issues that may affect its implementation. These findings underscore the importance of strengthening the security of AI-based applications to enhance public acceptability of related health policies and to support the safe integration of tools such as ChatGPT into the health care system. CI - (c) Hessah Al Suwaidan, Arwa Althumairi, Saja A Al-Rayes, Khalid Alkhurayji. Originally published in JMIR Formative Research (https://formative.jmir.org). FAU - Al Suwaidan, Hessah AU - Al Suwaidan H AUID- ORCID: 0000-0002-6535-8455 AD - Health Information Management and Technology Department, College of Public Health, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. FAU - Althumairi, Arwa AU - Althumairi A AUID- ORCID: 0000-0002-0371-408X AD - Health Information Management and Technology Department, College of Public Health, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. FAU - Al-Rayes, Saja A AU - Al-Rayes SA AUID- ORCID: 0000-0001-9908-7756 AD - Health Information Management and Technology Department, College of Public Health, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. FAU - Alkhurayji, Khalid AU - Alkhurayji K AUID- ORCID: 0009-0007-9394-1668 AD - Research, Statistics, and Information Department, Saudi Central Board for Accreditation of Healthcare Institutions, Wadi Alsaheya, Riyadh, 12264, Saudi Arabia, 966596181916. LA - eng PT - Journal Article DEP - 20260427 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Saudi Arabia MH - Female MH - Adult MH - Middle Aged MH - Surveys and Questionnaires MH - Adolescent MH - *Perception MH - Young Adult MH - Generative Artificial Intelligence MH - *Attitude to Health MH - Health Knowledge, Attitudes, Practice PMC - PMC13119390 OTO - NOTNLM OT - AI OT - ChatGPT OT - Saudi Arabia OT - artificial intelligence OT - health attitude OT - health informatics COIS- Conflicts of Interest: None declared. EDAT- 2026/04/27 18:33 MHDA- 2026/04/27 18:34 PMCR- 2026/04/27 CRDT- 2026/04/27 14:44 PHST- 2025/06/18 00:00 [received] PHST- 2026/03/10 00:00 [revised] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/04/27 18:34 [medline] PHST- 2026/04/27 18:33 [pubmed] PHST- 2026/04/27 14:44 [entrez] PHST- 2026/04/27 00:00 [pmc-release] AID - v10i1e79276 [pii] AID - 79276 [pii] AID - 10.2196/79276 [doi] PST - epublish SO - JMIR Form Res. 2026 Apr 27;10:e79276. doi: 10.2196/79276. PMID- 42043699 OWN - NLM STAT- MEDLINE DCOM- 20260624 LR - 20260813 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Apr 27 TI - A systematic review of psychometric scales that assess familial, lifestyle, and behavioural factors for children living with overweight or obesity, or at risk of developing obesity. LID - 10.1007/s40519-026-01860-6 [doi] LID - 56 AB - Over the past four decades, global childhood obesity rates have risen significantly. Modifiable factors such as diet, physical activity, family dynamics, and screen time play an important role in childhood obesity and are often targeted in interventions. However, no comprehensive review of instruments assessing these factors has been published, prompting this study. A systematic review following PRISMA guidelines was conducted to identify validated multidimensional lifestyle assessment instruments (defined as those assessing at least two constructs) for children aged 2-12 years living with overweight or obesity. Four databases (Pubmed, PsychINFO, CINAHL, and Embase) were searched for studies from 1980 to 2024. First, 7844 studies were screened by title and abstract by two independent reviewers. The resultant 141 full-text studies were also independently reviewed by 2 reviewers. Study quality was assessed and data on psychometric properties were extracted. Thirteen papers covering eight instruments were included: Healthy Kids (Ninos Sanos), Family Health Behaviour Scale, Lifestyle Behaviour Checklist, Family Nutrition Physical Activity screening tool, Family Eating and Activity Habits Questionnaire, Home Environment Survey, Child Obesity Risk Questionnaire 2-5, and Energy Retention Behaviour Scale for Children. These instruments assessed various factors, including diet, mealtime routines, physical activity, sedentary behaviour, sleep, parental beliefs and the home environment. The instruments showed significant heterogeneity, with no single instrument covering the entire 2-12 years age range or measuring the same constructs comprehensively. The quality of the reviewed studies varied, particularly in the range of psychometric properties examined. Based on the results of this review, there is no one measure shown to be validated specifically for children living with overweight/obesity that addresses a broad range of domains that respond to change over time.Level II: Evidence obtained from well-designed controlled trials without randomisation. CI - (c) 2026. The Author(s). FAU - Davis, Brid Aine AU - Davis BA AUID- ORCID: 0000-0003-4606-4432 AD - School of Psychology, University College Dublin, Belfield, Dublin 4, Ireland. FAU - O'Dwyer, Claire AU - O'Dwyer C AUID- ORCID: 0000-0002-7978-9731 AD - School of Psychology, University College Dublin, Belfield, Dublin 4, Ireland. FAU - Carr, Alan AU - Carr A AUID- ORCID: 0000-0003-4563-8852 AD - School of Psychology, University College Dublin, Belfield, Dublin 4, Ireland. FAU - Looney, Kathy AU - Looney K AUID- ORCID: 0000-0002-0815-2012 AD - School of Psychology, University College Dublin, Belfield, Dublin 4, Ireland. kathy.looney@ucd.ie. LA - eng GR - D Psych Sc/Health Service Executive/ PT - Journal Article PT - Systematic Review DEP - 20260427 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - *Psychometrics MH - Pediatric Obesity/epidemiology/psychology MH - *Overweight/epidemiology/psychology MH - Family/psychology MH - Exercise/statistics & numerical data MH - Health Behavior/physiology MH - Life Style MH - Humans MH - Child, Preschool MH - Child MH - Risk Factors PMC - PMC13253707 OTO - NOTNLM OT - Childhood obesity OT - health-related quality of life (HRQOL) OT - lifestyle measures COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/04/27 12:34 MHDA- 2026/06/15 11:32 PMCR- 2026/04/27 CRDT- 2026/04/27 11:23 PHST- 2024/06/17 00:00 [received] PHST- 2026/04/09 00:00 [accepted] PHST- 2026/06/15 11:32 [medline] PHST- 2026/04/27 12:34 [pubmed] PHST- 2026/04/27 11:23 [entrez] PHST- 2026/04/27 00:00 [pmc-release] AID - 10.1007/s40519-026-01860-6 [pii] AID - 1860 [pii] AID - 10.1007/s40519-026-01860-6 [doi] PST - epublish SO - Eat Weight Disord. 2026 Apr 27;31(1):56. doi: 10.1007/s40519-026-01860-6. PMID- 42041084 OWN - NLM STAT- MEDLINE DCOM- 20260927 LR - 20260927 IS - 1940-1019 (Electronic) IS - 0022-3980 (Linking) VI - 160 IP - 8 DP - 2026 TI - The Effect of Weight Stigma on Adolescent Health: Mediating and Moderating Roles of Social Support and Personality Traits. PG - 985-1008 LID - 10.1080/00223980.2026.2661586 [doi] AB - Weight stigma is a common psychosocial stressor among adolescents and an important determinant of mental and physical well-being. However, the mechanisms through which it affects health outcomes remain insufficiently understood. This study explored the mediating and moderating roles of personality traits and perceived social support in the relationship between weight stigma and health outcomes in adolescents. A cross-sectional self-report study was conducted with 1,011 high school students (59.64% female; M(age) = 16.50 years, SD(age) = 1.10), using validated measures of weight stigma, Big Five personality traits, perceived social support, mental health (anxiety, depression, stress), and somatization. Mediation and moderation were tested using path analysis models, controlling for gender and BMI. Results showed that weight stigma directly predicted higher anxiety, depression, stress, and somatization. Positive indirect effects of weight stigma on health outcomes were observed through neuroticism, family support, and teacher support. Frequent stigmatization predicted lower levels of perceived social support and higher neuroticism, which in turn predicted poorer health outcomes. Moderation analyses showed that higher neuroticism and extraversion increased the effects of weight stigma on anxiety, while extraversion buffered its effects on somatization. Interestingly, while family support generally serves as a protective factor against somatization, higher levels of support were associated with a stronger effect of weight stigma on somatization. These findings emphasize the complex interplay between weight stigma, individual traits, and social context, supporting a biopsychosocial understanding of adolescent health. Furthermore, they emphasize the need for a comprehensive prevention and intervention approach to support this vulnerable population. FAU - Ivancic, Ivana AU - Ivancic I AUID- ORCID: 0009-0008-9583-2649 AD - University of Rijeka. FAU - Kalebic Maglica, Barbara AU - Kalebic Maglica B AUID- ORCID: 0000-0002-6278-5582 AD - University of Rijeka. FAU - Kurtovic, Ana AU - Kurtovic A AUID- ORCID: 0000-0003-0779-5312 AD - Josip Juraj Strossmayer University of Osijek. LA - eng PT - Journal Article DEP - 20260427 PL - United States TA - J Psychol JT - The Journal of psychology JID - 0376332 SB - IM MH - Humans MH - Female MH - Adolescent MH - *Social Support MH - Male MH - *Personality MH - *Social Stigma MH - Cross-Sectional Studies MH - *Anxiety/psychology MH - *Depression/psychology MH - *Adolescent Health MH - *Stress, Psychological/psychology MH - Somatoform Disorders/psychology OTO - NOTNLM OT - Weight stigma OT - adolescents OT - big five personality traits OT - mental health OT - social support EDAT- 2026/04/27 12:34 MHDA- 2026/09/27 23:28 CRDT- 2026/04/27 07:33 PHST- 2026/09/27 23:28 [medline] PHST- 2026/04/27 12:34 [pubmed] PHST- 2026/04/27 07:33 [entrez] AID - 10.1080/00223980.2026.2661586 [doi] PST - ppublish SO - J Psychol. 2026;160(8):985-1008. doi: 10.1080/00223980.2026.2661586. Epub 2026 Apr 27. PMID- 42040637 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260427 LR - 20260813 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - The importance of physical education and the intention to be physically active as predictors of subjective well-being in secondary school adolescents. PG - 1748124 LID - 10.3389/fspor.2026.1748124 [doi] LID - 1748124 AB - INTRODUCTION: In recent years, concerns about adolescent mental health and declining physical activity levels have increased across European educational systems, including Portugal. Understanding how Physical Education (PE) and students' intention to remain physically active contribute to subjective well-being is therefore essential for guiding educational practices and health promotion strategies. Within this context, the present study aimed to analyze these relationships in a group of secondary school students in Portugal, with a view to proposing evidence-based recommendations. This study aimed to analyze the role of the importance attributed to Physical Education (PE) and the intention to be physically active as significant statistical predictors of subjective well-being (SWB) in Portuguese secondary school adolescents. METHODS: The sample consisted of 560 students, aged between 16 and 19 years, from different regions of Portugal. Validated scales were used to measure the variables of interest: Importance of PE, Intention to Be Active, Positive and Negative Affect, and Life Satisfaction. The data were analyzed using descriptive statistics, Spearman correlations, Kruskal-Wallis and Mann-Whitney tests, linear regressions, and simple mediation models (Hayes' model 4). RESULTS: The results indicated high levels of physical activity intention and life satisfaction, low levels of negative affect, and strong internal consistency in the scales used. The importance attributed to PE and the intention to be active were significantly associated with positive affect and life satisfaction, with intention partially mediating the relationship between the importance of PE and positive affect, and fully mediating the relationship with negative affect. No significant mediation was found for life satisfaction. Additionally, significant differences were observed across school years, highlighting the 11th year as a stage of greater emotional vulnerability.x. DISCUSSION: The findings suggest the need to reinforce the value of PE in the curriculum and to promote educational strategies that encourage regular physical activity as a way to enhance SWB in the school context. CI - (c) 2026 Batista, Rojo-Ramos, Castillo-Paredes and Galan-Arroyo. FAU - Batista, Marco AU - Batista M AD - Polytechnic University of Castelo Branco, Castelo Branco, Portugal. AD - SPRINT-IPCB, Sport Physical Activity and Health Research & Innovation Center, Castelo Branco, Portugal. FAU - Rojo-Ramos, Jorge AU - Rojo-Ramos J AD - Promoting a Healthy Society Research Group (PHeSO), Faculty of Sport Sciences, University of Extremadura, Caceres, Spain. FAU - Castillo-Paredes, Antonio AU - Castillo-Paredes A AD - Grupo AFySE, Investigacion en Actividad Fisica y Salud Escolar, Escuela de Pedagogia en Educacion Fisica, Facultad de Educacion, Universidad de Las Americas, Santiago, Chile. FAU - Galan-Arroyo, Carmen AU - Galan-Arroyo C AD - Promoting a Healthy Society Research Group (PHeSO), Faculty of Sport Sciences, University of Extremadura, Caceres, Spain. LA - eng PT - Journal Article DEP - 20260410 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13106526 OTO - NOTNLM OT - adolescence OT - behavioral intention OT - physical activity OT - physical education OT - subjective well-being COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/27 12:34 MHDA- 2026/04/27 12:35 PMCR- 2026/04/10 CRDT- 2026/04/27 07:09 PHST- 2025/11/17 00:00 [received] PHST- 2026/03/14 00:00 [revised] PHST- 2026/03/19 00:00 [accepted] PHST- 2026/04/27 12:35 [medline] PHST- 2026/04/27 12:34 [pubmed] PHST- 2026/04/27 07:09 [entrez] PHST- 2026/04/10 00:00 [pmc-release] AID - 10.3389/fspor.2026.1748124 [doi] PST - epublish SO - Front Sports Act Living. 2026 Apr 10;8:1748124. doi: 10.3389/fspor.2026.1748124. eCollection 2026. PMID- 42040062 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Do nutrition knowledge and health literacy influence food consumption patterns in Saudi youth aged 18 to 25? An analytical assessment using cross-sectional convenience sample. PG - 1806616 LID - 10.3389/fpubh.2026.1806616 [doi] LID - 1806616 AB - OBJECTIVE: Nutrition knowledge and health literacy are critical foundations for healthy dietary behaviors. However, their combined influence on food consumption patterns in Saudi young adults remains underexplored. This research investigated the levels and predictors of nutrition knowledge and health literacy, as well as their impact on food consumption patterns among a group of Saudi Arabian young people. METHODS: This was an online survey (structured, self-administered questionnaire) using a large convenience sample of students from different universities in Saudi Arabia. Nutrition knowledge, health literacy, and food consumption patterns were evaluated using the validated CoNKS, the HLS-EU-Q16, and a regionally adapted 10-item food group checklist, respectively. Regression models were fitted to evaluate the predictors of nutrition knowledge and health literacy, and their associations with food consumption frequency. RESULTS: The sample comprised 827 participants, aged 18 to 25. The prevalence of unsatisfactory nutrition knowledge was 70.5% and limited health literacy was 58.3%. Significant factors associated with unsatisfactory nutrition knowledge included non-health science major, physical inactivity, no prior nutrition course, night eating syndrome, and limited health literacy. Key factors associated with limited health literacy included age (18-20 years), non-health science major, having an illiterate mother, and unsatisfactory nutrition knowledge. Furthermore, satisfactory nutrition knowledge and sufficient health literacy were independently associated with healthier food consumption patterns. Specifically, they were linked to higher odds of consuming fruits and vegetables (nutrition knowledge: OR = 1.76; health literacy: OR = 2.71) and meat, fish, and eggs (nutrition knowledge: OR = 2.67). Unsatisfactory nutrition knowledge was related to high-calorie foods intake (OR = 3.70). CONCLUSION: Both nutrition knowledge and health literacy are significant, modifiable factors associated with food consumption patterns among study participants. Integrated educational interventions targeting both competencies are recommended to improve dietary behaviors in this population. CI - Copyright (c) 2026 Alzain. FAU - Alzain, Mohannad A AU - Alzain MA AD - Department of Family Medicine, Faculty of Medicine, King Abdul Aziz University, Jeddah, Saudi Arabia. AD - Department of Family Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah, Saudi Arabia. AD - Family Medicine and Chronic Diseases Research Unit, King Fahd Medical Research Center, King Abdul Aziz University, Jeddah, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260409 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Saudi Arabia MH - *Health Literacy/statistics & numerical data MH - Female MH - Adolescent MH - Young Adult MH - Male MH - *Health Knowledge, Attitudes, Practice MH - Cross-Sectional Studies MH - Adult MH - *Feeding Behavior/psychology MH - Surveys and Questionnaires MH - Students/statistics & numerical data/psychology PMC - PMC13102618 OTO - NOTNLM OT - Saudi Arabia OT - dietary behaviors OT - food consumption patterns OT - health literacy OT - nutrition knowledge OT - young adults COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/27 12:34 MHDA- 2026/04/27 12:35 PMCR- 2026/04/09 CRDT- 2026/04/27 07:05 PHST- 2026/02/08 00:00 [received] PHST- 2026/03/19 00:00 [revised] PHST- 2026/03/24 00:00 [accepted] PHST- 2026/04/27 12:35 [medline] PHST- 2026/04/27 12:34 [pubmed] PHST- 2026/04/27 07:05 [entrez] PHST- 2026/04/09 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1806616 [doi] PST - epublish SO - Front Public Health. 2026 Apr 9;14:1806616. doi: 10.3389/fpubh.2026.1806616. eCollection 2026. PMID- 42039897 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260427 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Associations between food preferences, micronutrient insufficiency, and autonomic function in adolescents with a recent history of vasovagal syncope. PG - 1783737 LID - 10.3389/fnut.2026.1783737 [doi] LID - 1783737 AB - AIM OF THE STUDY: This study aimed to investigate the interrelationships between food preferences, micronutrient status, and autonomic function in adolescents with vasovagal syncope (VVS), exploring how dietary behaviour may contribute to syncope susceptibility. MATERIALS AND METHODS: We enrolled 138 adolescents with VVS and 78 age-matched healthy controls (13-17 years). Clinical assessment included syncope history, Modified Calgary Syncope Score (MCSS), and 24-h Holter monitoring for heart rate variability (HRV) analysis (SDANN, RMSSD, pNN50, TP, VLF, LF, HF, and LF/HF). Fasting serum levels of vitamins B6, B12, folate, and 25-hydroxyvitamin D (25(OH)D) were measured via ELISA. Food preferences were evaluated using a validated Ukrainian version of the Food Preference Questionnaire (FPQ) for adolescents and adults, covering vegetables, fruits, meat and fish, dairy, snacks, and starches. Data were analyzed using multiple linear regression, with assessment of FPQ reliability, construct, and discriminant validity. RESULTS: Adolescents with VVS exhibited lower serum B6, B12, and 25(OH)D compared with controls, while folate levels were similar. HRV analysis demonstrated increased TP alongside elevated LF/HF ratios, suggesting altered autonomic regulation characterized by relative sympathetic predominance and reduced parasympathetic modulation at baseline. The FPQ demonstrated high reliability and validity. VVS participants reported lower preferences for vegetables, meat and fish, and starches (all FDR-corrected), with a trend toward lower fruit preference that did not survive correction. Regression analyses showed that higher vegetable preference was associated with increased folate and cobalamin, whereas meat and fish preference was positively associated with B6. Vegetable preference was negatively associated with HF, while meat and fish and dairy preferences were negatively associated with SDANN and RMSSD. Dairy preference showed a negative association with B6 and multiple HRV parameters, while snack and starch preference had modest or no associations. Food preferences were generally weakly related to syncope severity, with only starch preference showing a significant association with MCSS scores after FDR correction. CONCLUSION: Adolescents with VVS exhibit distinct food preference patterns linked to micronutrient insufficiencies and altered HRV, suggesting an interaction between diet, nutrient status, and autonomic regulation. Integrating nutritional assessment and targeted interventions into clinical management may improve autonomic balance and reduce syncope burden. Future longitudinal and interventional studies are needed to clarify causal pathways and evaluate the efficacy of dietary and supplementation strategies in mitigating VVS episodes. CI - Copyright (c) 2026 Kovalchuk and Boyarchuk. FAU - Kovalchuk, Tetiana AU - Kovalchuk T AD - Department of Pediatrics, Ivan Horbachevsky Ternopil National Medical University of the Ministry of Health of Ukraine, Ternopil, Ukraine. FAU - Boyarchuk, Oksana AU - Boyarchuk O AD - Department of Pediatrics and Pediatric Surgery, Ivan Horbachevsky Ternopil National Medical University of the Ministry of Health of Ukraine, Ternopil, Ukraine. LA - eng PT - Journal Article DEP - 20260409 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13102588 OTO - NOTNLM OT - 25-hydroxyvitamin D OT - cobalamin OT - folate OT - food preferences OT - heart rate variability OT - pediatric vasovagal syncope OT - pyridoxine COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/27 12:33 MHDA- 2026/04/27 12:34 PMCR- 2026/04/09 CRDT- 2026/04/27 07:03 PHST- 2026/01/08 00:00 [received] PHST- 2026/03/10 00:00 [revised] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/04/27 12:34 [medline] PHST- 2026/04/27 12:33 [pubmed] PHST- 2026/04/27 07:03 [entrez] PHST- 2026/04/09 00:00 [pmc-release] AID - 10.3389/fnut.2026.1783737 [doi] PST - epublish SO - Front Nutr. 2026 Apr 9;13:1783737. doi: 10.3389/fnut.2026.1783737. eCollection 2026. PMID- 42037831 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260427 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 3 DP - 2026 Mar TI - Prevalence of Malnutrition and Its Associated Factors Among Children in the 5-15 Years Age Group: A Community-Based Cross-Sectional Study From Selected Rural Areas of Khordha District, Odisha. PG - e105874 LID - 10.7759/cureus.105874 [doi] LID - e105874 AB - Introduction Malnutrition is one of the most common causes of morbidity and mortality among children and adolescents throughout the world. Various factors, including socio-demographic characteristics, poor feeding practices, and childhood diseases, contribute to malnutrition. This study aimed to assess the prevalence of malnutrition and its associated factors among 5 to 15-year-old children of selected rural areas of Khordha District, Odisha. Method A community-based descriptive cross-sectional study was conducted among children in Simlipatana and Kujjimahal villages of Khordha district, Odisha. All eligible children (5 to 15 years of age) residing in both study areas were included in the sampling frame. A total of 380 participants were enrolled in the study, based on a 45% prevalence, using simple random sampling. Data were collected using participants' socio-demographic characteristics, anthropometric measurements, the IAP growth chart app, and a validated questionnaire to assess factors associated with malnutrition. The data were analysed using SPSS software, version 26.0 (IBM Corp., Armonk, NY). Results The study findings revealed that the prevalence of malnutrition was 41.3%, with 13.9% underweight, 12.9% overweight, 5.3% obese, and varying degrees of stunting. Among malnourished children, 56.32% were female, and nearly half (43.67%) were male. Malnutrition was significantly associated with sociodemographic factors like family type, income, parental education, and hygiene practices. Dietary intake patterns, such as consumption of milk, pulses, and fruits. Logistic regression analysis revealed that four key significant factors were associated with malnutrition of children, including large family size (odds ratio (OR) = 2.019, P < 0.003), poor hygiene (OR = 2.082, P < 0.006), lack of parental education (OR = 2.045, P < 0.003), and inadequate dietary intake (OR) = 2.115, P < 0.011). Conclusions The overall prevalence of malnutrition was 41.3%, and it decreased with age. Dietary patterns and sociodemographic profiles are significantly associated with the development of malnutrition. CI - Copyright (c) 2026, Singh et al. FAU - Singh, Rekha AU - Singh R AD - Pediatric Nursing, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar, IND. FAU - Nayak, Geetarani AU - Nayak G AD - Pediatric Nursing, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar, IND. FAU - Satapathy, Amit AU - Satapathy A AD - Pediatrics, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar, IND. LA - eng PT - Journal Article DEP - 20260326 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13110084 OTO - NOTNLM OT - associated factor OT - children and adolescent OT - malnutrition OT - prevalence OT - stunting and undernutrition COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Ethics Committee, All India of Institute of Medical Sciences, Bhubaneshwar issued approval IEC/AIIMS BBSR/Nursing/2019-20/35. Approved. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/04/27 12:34 MHDA- 2026/04/27 12:35 PMCR- 2026/03/26 CRDT- 2026/04/27 06:46 PHST- 2026/03/25 00:00 [accepted] PHST- 2026/04/27 12:35 [medline] PHST- 2026/04/27 12:34 [pubmed] PHST- 2026/04/27 06:46 [entrez] PHST- 2026/03/26 00:00 [pmc-release] AID - 10.7759/cureus.105874 [doi] PST - epublish SO - Cureus. 2026 Mar 26;18(3):e105874. doi: 10.7759/cureus.105874. eCollection 2026 Mar. PMID- 42037051 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260813 IS - 1099-0968 (Electronic) IS - 1072-4133 (Print) IS - 1072-4133 (Linking) VI - 34 IP - 5 DP - 2026 Sep TI - Associations Between Avoidant/Restrictive Food Intake Disorder Dimensions and Obsessive-Compulsive Symptomatology. PG - 1327-1335 LID - 10.1002/erv.70122 [doi] AB - OBJECTIVE: Although obsessive-compulsive disorder (OCD) commonly co-occurs with anorexia nervosa and bulimia nervosa, less is known about its relationship with avoidant/restrictive food intake disorder (ARFID) dimensions. Whether associations between ARFID dimensions and OCD differ by sex is also unclear. We examined associations between ARFID dimensions and OCD symptoms by sex, accounting for depression and anxiety. METHODS: Data from 3120 participants ages 15+ in the ARFID Genes and Environment (ARFID-GEN) study were analyzed. ARFID dimensions (i.e., sensory sensitivity; low appetite/lack of interest in food; and fear of aversive consequences), OCD symptoms, anxiety, and depression were assessed using validated self-report measures. We evaluated associations between ARFID dimensions and OCD symptoms using general linear models, adjusting for depression and anxiety. RESULTS: ARFID dimensions were significantly associated with OCD symptoms. After adjusting for depression and anxiety, these associations were attenuated but remained significant for all ARFID dimensions. Associations between ARFID dimensions and OCD symptoms varied by sex. CONCLUSION: The relation between ARFID symptomatology and OCD warrants further exploration across the developmental spectrum in which ARFID appears. Clinically, bidirectional screening may improve diagnostic clarity and be informative to tailor interventions appropriately. TRIAL REGISTRATION: ARFID-GEN is registered in clinicaltrials.gov (NCT05605067). CI - (c) 2026 The Author(s). European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd. FAU - Aguilar, Mariana Valdez AU - Aguilar MV AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Giulumian, Gabriela K AU - Giulumian GK AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Rodriguez, Isabel AU - Rodriguez I AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Baker, Jessica H AU - Baker JH AUID- ORCID: 0000-0002-3997-2398 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Surti, Preina P AU - Surti PP AD - Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Dinkler, Lisa AU - Dinkler L AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Guintivano, Jerry AU - Guintivano J AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Johnson, Jessica S AU - Johnson JS AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - MacDermod, Casey M AU - MacDermod CM AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Ortiz, Shelby N AU - Ortiz SN AUID- ORCID: 0000-0001-8088-8254 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Pisetsky, Emily M AU - Pisetsky EM AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - White, Jennifer P AU - White JP AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Micali, Nadia AU - Micali N AUID- ORCID: 0000-0001-5571-2273 AD - Center for Eating and Feeding Disorders Research, Mental Health Center Ballerup, Copenhagen University Hospital-Mental Health Services CPH, Copenhagen, Denmark. AD - Great Ormond Street Institute of Child Health, University College London, London, UK. AD - Institute for Biological Psychiatry, Mental Health Centre Sct Hans, Copenhagen University Hospital-Mental Health Services, Copenhagen, Denmark. FAU - Bulik, Cynthia M AU - Bulik CM AUID- ORCID: 0000-0001-7772-3264 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Thornton, Laura M AU - Thornton LM AUID- ORCID: 0000-0001-9384-7988 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Wu, Ya-Ke AU - Wu YK AUID- ORCID: 0000-0001-8990-3449 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - School of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. LA - eng SI - ClinicalTrials.gov/NCT05605067 GR - R56MH129437/MH/NIMH NIH HHS/United States GR - Office of Community Development/ GR - R56MH129437/MH/NIMH NIH HHS/United States PT - Journal Article DEP - 20260426 PL - England TA - Eur Eat Disord Rev JT - European eating disorders review : the journal of the Eating Disorders Association JID - 9436977 SB - IM MH - Humans MH - *Obsessive-Compulsive Disorder/psychology/complications MH - Female MH - Male MH - *Avoidant Restrictive Food Intake Disorder/psychology MH - Adult MH - Adolescent MH - Anxiety/psychology MH - Depression/psychology MH - Young Adult MH - Middle Aged PMC - PMC13432419 OTO - NOTNLM OT - anxiety OT - depression OT - eating disorders OT - feeding disorders OT - obsessive-compulsive symptomatology COIS- Dr. Bulik receives royalties from Pearson Education Inc. Dr. Dinkler has received personal fees from Baxter Medical AB and Fresenius Kabi AB outside the submitted work. Other authors declare no competing interests. EDAT- 2026/04/27 06:31 MHDA- 2026/08/03 18:37 PMCR- 2026/08/03 CRDT- 2026/04/27 02:52 PHST- 2025/11/18 00:00 [revised] PHST- 2025/05/09 00:00 [received] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/08/03 18:37 [medline] PHST- 2026/04/27 06:31 [pubmed] PHST- 2026/04/27 02:52 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - ERV70122 [pii] AID - 10.1002/erv.70122 [doi] PST - ppublish SO - Eur Eat Disord Rev. 2026 Sep;34(5):1327-1335. doi: 10.1002/erv.70122. Epub 2026 Apr 26. PMID- 42036681 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260813 IS - 2072-1315 (Electronic) IS - 1606-0997 (Print) IS - 1606-0997 (Linking) VI - 45 IP - 1 DP - 2026 Apr 26 TI - Predicting fast food avoidance behavior among male adolescents: a structural equation modeling approach to the theory of planned behavior. LID - 10.1186/s41043-026-01320-y [doi] LID - 155 AB - BACKGROUND: Fast food consumption is a growing public health concern, particularly among adolescents, due to its association with obesity and chronic diseases. Understanding the behavioral determinants of fast-food avoidance can inform the design of effective interventions targeting male adolescents. OBJECTIVE: This study aimed to investigate the determinants of fast-food avoidance behaviors among male high school students in Shiraz, Iran, using the Theory of Planned Behavior (TPB) and Structural Equation Modeling (SEM). METHODS: A cross-sectional study was conducted among 862 male students in grades 1 and 2 of high school in Shiraz in 2025. A multi-stage sampling strategy was applied, whereby 16 high schools were randomly selected from four educational districts. Within selected schools, classes and students were recruited using a convenience-based approach, and all eligible students present in the selected classes were invited to participate. Data were collected using a demographic questionnaire and a validated TPB-based instrument assessing knowledge, attitude, subjective norms, perceived behavioral control (PBC), behavioral intention, and fast-food avoidance behavior. Data analysis was performed using JAMOVI (v2.5.6), and SEM was employed to test the hypothesized TPB model. RESULTS: The final TPB model demonstrated excellent fit indices (chi(2)/df = 2.04, CFI = 0.94, RMSEA = 0.05). Attitude (beta = 0.58), subjective norms (beta = 0.34), and PBC (beta = 0.26) significantly predicted behavioral intention (p < .001), which in turn strongly predicted fast-food avoidance behavior (beta = 0.49, p < .001). PBC also had a direct effect on behavior (beta = 0.31). Knowledge exerted an indirect effect on behavior through attitude and intention. Demographic variables, including parental education, household income, and maternal employment, were associated with TPB constructs. CONCLUSION: Fast-food avoidance behaviors among male adolescents are primarily influenced by motivational and control beliefs. From a practical and policy perspective, school-based nutrition education programs and adolescent health policies should prioritize strengthening positive attitudes, enhancing perceived behavioral control, and reinforcing supportive social norms to promote healthier dietary behaviors and reduce fast-food consumption among adolescents. CI - (c) 2026. The Author(s). FAU - Ansarifard, Leila AU - Ansarifard L AD - Department of Nursing, Firooabad Higher Education Complex for Health, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Dahi, Ali Al AU - Dahi AA AD - Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Behzadinezhad, Sarayel AU - Behzadinezhad S AD - Department of Nursing, Firooabad Higher Education Complex for Health, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Hamedi, Andishe AU - Hamedi A AUID- ORCID: 0000-0003-4484-2915 AD - Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Asadollahi, Abdolrahim AU - Asadollahi A AUID- ORCID: 0000-0003-2265-5641 AD - Department of Gerontology, School of Health, Shiraz University of Medical Sciences, Razi Ave, Shiraz, Iran. FAU - Golab, Farzaneh Ghaleh AU - Golab FG AD - Department of Healthcare Management, School of Management and Medical Informatics, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Sendall, Marguerite Claire AU - Sendall MC AD - Department of Environmental and Public Health, Abu Dhabi University, Abu Dhabi, United Arab Emirates. FAU - Jeihooni, Ali Khani AU - Jeihooni AK AD - Department of Public Health, Nutrition Research Center, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran. khani_1512@yahoo.com. LA - eng PT - Journal Article DEP - 20260426 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 SB - IM MH - Humans MH - Male MH - Theory of Planned Behavior MH - Adolescent MH - Cross-Sectional Studies MH - Iran MH - *Fast Foods MH - *Adolescent Behavior/psychology MH - Latent Class Analysis MH - Health Knowledge, Attitudes, Practice MH - Surveys and Questionnaires MH - Intention MH - *Feeding Behavior/psychology MH - Students/psychology PMC - PMC13289231 OTO - NOTNLM OT - Adolescent OT - Dietary Behaviors OT - Fast Food Avoidance OT - Fast Foods OT - Feeding Behavior OT - Male OT - Male Adolescents OT - Models OT - Psychological OT - Structural Equation Modeling OT - Surveys and Questionnaires OT - Theory of Planned Behavior COIS- Declarations. Ethics approval and consent to participate: This study protocol was approved by the ethics committee of Shiraz University of Medical Sciences. All study participants provided written informed consent. Informed consent was obtained from a parent and/or legal guardian of all the study participants as the subjects are under 16 years old. The ethics committee approved the procedure for verbal consent since the study is observational and respected the code of ethics as stated in the declarations of Helsinki. Consent for publication: None. Competing interests: The authors declare no competing interests. EDAT- 2026/04/27 00:30 MHDA- 2026/06/23 18:34 PMCR- 2026/04/26 CRDT- 2026/04/26 23:48 PHST- 2025/12/15 00:00 [received] PHST- 2026/04/02 00:00 [accepted] PHST- 2026/06/23 18:34 [medline] PHST- 2026/04/27 00:30 [pubmed] PHST- 2026/04/26 23:48 [entrez] PHST- 2026/04/26 00:00 [pmc-release] AID - 10.1186/s41043-026-01320-y [pii] AID - 1320 [pii] AID - 10.1186/s41043-026-01320-y [doi] PST - epublish SO - J Health Popul Nutr. 2026 Apr 26;45(1):155. doi: 10.1186/s41043-026-01320-y. PMID- 42035008 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260813 IS - 1471-2369 (Electronic) IS - 1471-2369 (Linking) VI - 27 IP - 1 DP - 2026 Apr 25 TI - Kidney function among adult sickle cell disease patients at Ahmadu Bello University Teaching Hospital, Zaria, Nigeria. LID - 10.1186/s12882-026-04999-7 [doi] LID - 361 AB - BACKGROUND: Sickle cell disease (SCD) patients are certainly experiencing improved longevity with improved care and it is not unexpected that long-term complications including kidney diseases are being seen more often than before. Unfortunately, late diagnosis is not unusual. This can in part be explained by some aspects of pathogenesis of kidney disease in SCD including body compensatory mechanisms such as hyperfiltration with its associated lower creatinine levels and exaggerated estimated glomerular filtration rate (eGFR). Worse still, no single eGFR formula has been validated across board in this patient population. Based on the forgoing, it is not surprising that there is paucity of data regarding kidney disease among SCD patients even in Nigeria with 2-3% of her population affected, with about 150,000 new-borns affected yearly and 50 million people carrying the sickle cell trait representing the highest burden of SCD globally. Hence, this study is relevant to the field of nephrology as it is expected to draw attention to this emerging cause of kidney disease as it were and also serve as a reminder to non-nephrologists to look beyond serum creatinine levels and eGFR to assess urine of SCD patients for early evidence of kidney disease including loss of urine concentration and pH regulation ability as well as microalbuminuria. AIMS: (1) This study was conducted to evaluate kidney function among patients with SCD in ABUTH, Zaria. (2) To assess the relationship of BMI, sex, age, Blood pressure, and disease duration, on kidney dysfunction among patients with SCD in ABUTH, Zaria. METHOD: This was cross sectional descriptive study involving 210 SCD patients (188 HbSS and 22 HbSC) attending Haematology Clinic in ABUTH Zaria and 210 apparently healthy controls. The subject and control groups were selected using convenience sampling technique. Clinical examinations such as body mass index, blood pressure, were done for both patients and controls. Glomerular Filtration Rates were estimated using (CKD-EPI equation). Albuminuria was quantified using albumin creatinine ratio. Tubular function was assessed for pH and specific gravity (SG) using dip sticks and hygrometer respectively. All data were checked for errors before entering into computer programme version 17.0 SPSS for windows. Categorical data were represented as diagram (charts and tables) while continuous variable data were represented as mean and standard deviation. Student t- test and Pearson's Chi square were used to test for relationship. RESULTS: The study found the prevalence of albuminuria to be 47.2% among patients with SCD in ABUTH Zaria. The prevalence of CKD from stages 3-5 using eGFR was found to be 8.6%. It was observed that 35.2% of the patients with SCD in this study were unable to acidify their urine and 33.3% of them have impaired ability to concentrate their urine. A significant relationship was observed between blood pressure, and ACR with p < 0.001. An inverse relationship between blood pressure and eGFR was observed with p < 0.001. The study shows a significant inverse relationship between age and eGFR with p < 0.001. A positive significant relationship was observed between age and ACR p < 0.001. No significant relationship was observed between BMI and kidney function. Limitations of this study: (1) Lack of determination of HbF to determine its impacts on kidney function. (2) History of use of Hydroxyurea and its impacts on kidney function couldn't be obtained. CONCLUSION: This study has shown high prevalence of albuminuria, impaired urine acidification and urine concentrating ability among patients with SCD. A significant relationship was observed between increasing age, BP and kidney dysfunction (albuminuria, eGFR,) among patients with SCD in ABUTH Zaria. This study therefore, highlights the importance of early screening and detection of markers of chronic kidney among patients with SCD, so that early intervention can be deployed to retard its progression. FAU - Musa, Oguche Sunday AU - Musa OS AD - Renal Unit, Department of Medicine, ABUTH- Zaria, Shika, Zaria, Nigeria. FAU - Ibrahim, Kwaifa Salihu AU - Ibrahim KS AD - Renal Unit, Department of Medicine, ABUTH- Zaria, Shika, Zaria, Nigeria. kwaifasalihu@gmail.com. AD - Depart of Internal Medicine Wuse District Hospital, Abuja, Nigeria. kwaifasalihu@gmail.com. AD - Department of Medicine, Nile University, Abuja, Nigeria. kwaifasalihu@gmail.com. FAU - Bosan, Istifanus Bala AU - Bosan IB AD - Renal Unit, Department of Medicine, ABUTH- Zaria, Shika, Zaria, Nigeria. FAU - Ibrahim, Abubakar AU - Ibrahim A AD - Renal Unit, Department of Medicine, ABUTH- Zaria, Shika, Zaria, Nigeria. FAU - Abdul-Aziz, Hassan AU - Abdul-Aziz H AD - Department of Haematology, ABUTH Zaria, Shika, Zaria, Nigeria. FAU - Moses, Tuko Tari AU - Moses TT AD - Renal Unit, Department of Medicine, ABUTH- Zaria, Shika, Zaria, Nigeria. LA - eng PT - Journal Article DEP - 20260425 PL - England TA - BMC Nephrol JT - BMC nephrology JID - 100967793 RN - AYI8EX34EU (Creatinine) SB - IM MH - Humans MH - Female MH - *Anemia, Sickle Cell/physiopathology/epidemiology/diagnosis MH - Nigeria/epidemiology MH - Male MH - Adult MH - *Glomerular Filtration Rate/physiology MH - Young Adult MH - *Hospitals, Teaching/trends MH - Cross-Sectional Studies MH - Middle Aged MH - Creatinine/blood MH - Albuminuria/epidemiology MH - *Kidney/physiopathology MH - *Kidney Diseases/epidemiology/physiopathology/diagnosis MH - Kidney Function Tests MH - Adolescent PMC - PMC13270705 OTO - NOTNLM OT - Albuminuria OT - Kidney functions OT - Sickle cell disease OT - Urinary Specific gravity COIS- Declarations. Ethical approval: Ethical approval for the study was sought and obtained from abuth health research ethics committee (HREC). according to helsinki abuth/hrec/cl/05. Consent for publication: All authors have read and approved the final version of this manuscript and consented to its submission to the BMC journal. The authors have confirmed that the work is original and has not been submitted for publication previously and is not under any consideration elsewhere. Competing interests: The authors declare no competing interests. EDAT- 2026/04/26 06:38 MHDA- 2026/06/28 06:36 PMCR- 2026/04/25 CRDT- 2026/04/26 00:08 PHST- 2025/06/17 00:00 [received] PHST- 2026/04/14 00:00 [accepted] PHST- 2026/06/28 06:36 [medline] PHST- 2026/04/26 06:38 [pubmed] PHST- 2026/04/26 00:08 [entrez] PHST- 2026/04/25 00:00 [pmc-release] AID - 10.1186/s12882-026-04999-7 [pii] AID - 4999 [pii] AID - 10.1186/s12882-026-04999-7 [doi] PST - epublish SO - BMC Nephrol. 2026 Apr 25;27(1):361. doi: 10.1186/s12882-026-04999-7. PMID- 42034862 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20261010 IS - 1433-0350 (Electronic) IS - 0256-7040 (Linking) VI - 42 IP - 1 DP - 2026 Apr 25 TI - Ultrasonographic assessment of subarachnoid space width in healthy infants aged 0-3 months: normative data and associations with anthropometric parameters. LID - 180 [pii] LID - 10.1007/s00381-026-07278-w [doi] AB - PURPOSE: The aim of this study was to establish ultrasonography-based reference values for subarachnoid space width and to examine associations between anthropometric Z-scores and these measurements in healthy infants aged 0-3 months. METHODS: This retrospective cross-sectional study included 125 healthy infants aged 0-3 months who underwent cranial ultrasound examinations. Subarachnoid space dimensions were measured bilaterally at the coronal level of the foramen of Monro, including craniocortical width (CCW), sinocortical width (SCW), and interhemispheric width (IHW). Age, body weight (BW), body height (BH), body mass index (BMI), body surface area (BSA), and head circumference (HC) Z-scores were analyzed for associations with subarachnoid space dimensions. Intraobserver reliability was evaluated using the intraclass correlation coefficient (ICC, two-way mixed-effects model). RESULTS: Mean values for CCW, SCW, and IHW increased progressively with age. Age was the only variable independently associated with CCW and SCW, while no significant anthropometric associations were found for IHW. Based on the 95th percentile, the proposed upper limits were 3.1 mm for CCW, 3.8 mm for SCW, and 4.2 mm for IHW. ICC values ranged from 0.93 to 0.95, indicating excellent intraobserver agreement. CONCLUSIONS: This study establishes ultrasonography-based normative data and describes growth-related associations for subarachnoid space width during the first 3 months of life. These findings provide a practical reference for interpreting subarachnoid space dimensions during early infancy. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Colak, Edis AU - Colak E AD - Department of Pediatric Radiology, Dr. Behcet Uz Children's Disease and Pediatric Surgery Training and Research Hospital, Izmir Faculty of Medicine, University of Health Sciences, Izmir, Turkey. drediscolak@gmail.com. AD - Department of Biophysics, Faculty of Medicine, Ege University, Izmir, Turkey. drediscolak@gmail.com. FAU - Karaoglu, Pakize AU - Karaoglu P AD - Department of Pediatric Neurology, Dr. Behcet Uz Children's Disease and Pediatric Surgery Training and Research Hospital, Izmir Faculty of Medicine, University of Health Sciences, Izmir, Turkey. FAU - Karaman, Huseyin Husnu AU - Karaman HH AD - Department of Pediatric Radiology, Dr. Behcet Uz Children's Disease and Pediatric Surgery Training and Research Hospital, Izmir Faculty of Medicine, University of Health Sciences, Izmir, Turkey. FAU - Unalp, Aycan AU - Unalp A AD - Department of Pediatric Neurology, Dr. Behcet Uz Children's Disease and Pediatric Surgery Training and Research Hospital, Izmir Faculty of Medicine, University of Health Sciences, Izmir, Turkey. FAU - Orbatu, Dilek AU - Orbatu D AD - Department of Neonatal Intensive Care, Dr. Behcet Uz Children's Disease and Pediatric Surgery Training and Research Hospital, Izmir Faculty of Medicine, University of Health Sciences, Izmir, Turkey. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260425 PL - Germany TA - Childs Nerv Syst JT - Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery JID - 8503227 SB - IM MH - Humans MH - *Subarachnoid Space/diagnostic imaging/anatomy & histology MH - Infant MH - Male MH - Female MH - Infant, Newborn MH - Cross-Sectional Studies MH - Reference Values MH - Retrospective Studies MH - *Anthropometry MH - Ultrasonography OTO - NOTNLM OT - Anthropometric associations OT - Cerebrospinal fluid OT - Cranial ultrasonography OT - Infants OT - Intraclass correlation coefficient OT - Normative data OT - Subarachnoid space COIS- Declarations. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Institutional Ethics Committee (Protocol No. GOA-217). Consent for publication: The authors affirm that human research participants provided informed consent for publication of the images in Figs. 1, 2, and 3. Conflict of interest: The authors declare no competing interests. EDAT- 2026/04/26 05:13 MHDA- 2026/04/26 06:38 CRDT- 2026/04/25 23:58 PHST- 2025/11/07 00:00 [received] PHST- 2026/04/14 00:00 [accepted] PHST- 2026/04/26 06:38 [medline] PHST- 2026/04/26 05:13 [pubmed] PHST- 2026/04/25 23:58 [entrez] AID - 10.1007/s00381-026-07278-w [pii] AID - 10.1007/s00381-026-07278-w [doi] PST - epublish SO - Childs Nerv Syst. 2026 Apr 25;42(1):180. doi: 10.1007/s00381-026-07278-w. PMID- 42034336 OWN - NLM STAT- MEDLINE DCOM- 20261029 LR - 20261029 IS - 1885-5857 (Electronic) IS - 1885-5857 (Linking) VI - 79 IP - 11 DP - 2026 Nov TI - Adapting the REVEAL Lite 2 score to the pediatric population through machine learning: insights from the REHIPED registry for pediatric pulmonary hypertension. PG - 886-898 LID - S1885-5857(26)00074-5 [pii] LID - 10.1016/j.rec.2026.03.006 [doi] AB - INTRODUCTION AND OBJECTIVES: Risk scores for pulmonary hypertension (PH) have been proven useful in adults. However, no risk score has been validated in pediatric populations. Our aim was to adapt the REVEAL Lite 2 score to pediatrics, including groups 1 (pulmonary arterial hypertension) and 3 (PH associated with lung diseases). METHODS: Data from the REHIPED was used, which is the PH registry of the Spanish Society of Pediatric Cardiology and Congenital Heart Disease. The registry also incorporates some Colombian centers. Patients in group 1 and group 3 were included. The score was derived using machine learning. The contribution of each variable and its cutoffs were identified through gradient boosting. The REVEAL Lite 2 variables were normalized and entered into the model, along with each patient's weight, sex, and age. Risk stratification into 3 categories (low, intermediate, and high risk) was performed. RESULTS: A total of 420 children were analyzed. The final model included functional class, age at diagnosis, heart rate, weight-for-height percentile, systolic blood pressure, natriuretic peptides, weight-for-age percentile, and 6-minute walk test. The area under the curve was 0.82, with an estimated area under the curve of 0.73 on unseen data. The log-rank P value for differences in transplant-free survival among the 3 risk strata (low, intermediate, and high) was<.001. HR for intermediate risk vs low risk was 3.10 (95%CI, 1.02-9.40; P=.046), and HR for high risk vs low risk was 12.30 (95%CI, 4.42-34.25; P <.001). CONCLUSIONS: Our score adequately stratifies the risk of PH in the pediatric population, including infants, and is based on noninvasive variables. CI - Copyright (c) 2026 Sociedad Espanola de Cardiologia. Published by Elsevier Espana, S.L.U. All rights reserved. FAU - Playan-Escribano, Julia AU - Playan-Escribano J AD - Servicio de Cardiologia, Instituto de Investigacion Sanitaria Gregorio Maranon, Hospital General Universitario Gregorio Maranon, Madrid, Spain; Centro de Investigacion Biomedica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain; Servicio de Cardiologia, Hospital Universitario del Sureste, Arganda del Rey, Madrid, Spain; Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain. Electronic address: julia.playan@gmail.com. FAU - Labrandero de Lera, Carlos AU - Labrandero de Lera C AD - Servicio de Cardiologia Pediatrica, Hospital Universitario La Paz, Madrid, Spain. FAU - Albert de la Torre, Leticia AU - Albert de la Torre L AD - Servicio de Cardiologia Pediatrica, Instituto Pediatrico del Corazon, Instituto de Investigacion Sanitaria 12 de Octubre (imas12), Hospital Universitario 12 de Octubre, Madrid, Spain. FAU - Rodriguez-Ogando, Alejandro AU - Rodriguez-Ogando A AD - Servicio de Cardiologia Pediatrica, Hospital General Universitario Gregorio Maranon, Madrid, Spain. FAU - Moreno-Galdo, Antonio AU - Moreno-Galdo A AD - Seccion de Neumologia Pediatrica, Servicio de Pediatria, Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus, Universitat Autonoma de Barcelona, Barcelona, Spain; Centro de Investigacion en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain. FAU - Guillen Rodriguez, Inmaculada AU - Guillen Rodriguez I AD - Servicio de Cardiologia y Hemodinamica Pediatricas, Hospital Virgen del Rocio, Seville, Spain. FAU - Sabate-Rotes, Anna AU - Sabate-Rotes A AD - Servicio de Cardiologia Pediatrica, Hospital Universitario Vall d'Hebron, Barcelona, Spain. FAU - Moya-Bonora, Amparo AU - Moya-Bonora A AD - Servicio de Cardiologia Pediatrica, Hospital Universitario La Fe, Valencia, Spain. FAU - Caicedo Cuenca, Lina Maria AU - Caicedo Cuenca LM AD - Servicio de Cardiologia Pediatrica, Clinica Shaio, Bogota, Colombia. FAU - Cerro-Marin, Maria Jesus AU - Cerro-Marin MJ AD - Servicio de Cardiologia Pediatrica, Instituto de Investigacion Biomedica Ramon y Cajal (IRYCIS), Hospital Universitario Ramon y Cajal, Madrid, Spain. Electronic address: majecerro@yahoo.es. CN - REHIPED investigators LA - eng LA - spa PT - Journal Article PT - Multicenter Study DEP - 20260423 PL - Spain TA - Rev Esp Cardiol (Engl Ed) JT - Revista espanola de cardiologia (English ed.) JID - 101587954 SB - IM MH - Humans MH - *Hypertension, Pulmonary/epidemiology/diagnosis/physiopathology/etiology MH - Female MH - *Registries MH - Male MH - Child MH - *Machine Learning MH - Risk Assessment/methods MH - Child, Preschool MH - Infant MH - Risk Factors MH - Spain/epidemiology MH - Colombia/epidemiology MH - Adolescent OTO - NOTNLM OT - Aprendizaje automatico OT - Epidemiology OT - Epidemiologia OT - Factores de riesgo OT - Hipertension pulmonar OT - Machine learning OT - Pediatrics OT - Pediatria OT - Pulmonary hypertension OT - Risk factors EDAT- 2026/04/26 05:13 MHDA- 2026/10/29 23:28 CRDT- 2026/04/25 19:24 PHST- 2026/01/08 00:00 [received] PHST- 2026/03/26 00:00 [accepted] PHST- 2026/10/29 23:28 [medline] PHST- 2026/04/26 05:13 [pubmed] PHST- 2026/04/25 19:24 [entrez] AID - S1885-5857(26)00074-5 [pii] AID - 10.1016/j.rec.2026.03.006 [doi] PST - ppublish SO - Rev Esp Cardiol (Engl Ed). 2026 Nov;79(11):886-898. doi: 10.1016/j.rec.2026.03.006. Epub 2026 Apr 23. PMID- 42033144 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261009 IS - 1537-6591 (Electronic) IS - 1058-4838 (Print) IS - 1058-4838 (Linking) VI - 83 IP - 3 DP - 2026 Oct 7 TI - Updated Hepatitis D Seroprevalence Among Hepatitis B Surface Antigen-Positive Persons Aged >/=6 Years in the United States, National Health and Nutrition Examination Survey, 2007‒2018. PG - e530-e532 LID - 10.1093/cid/ciag274 [doi] AB - To validate the accuracy of previously published US seroprevalence estimates for hepatitis D virus (HDV) antibody, we retested National Health and Nutrition Examination Survey samples from 2007 to 2018 using a different assay. We found the HDV seroprevalence among hepatitis B surface antigen-positive participants aged >/=6 years to be 1.26%. CI - Published by Oxford University Press on behalf of Infectious Diseases Society of America 2026. FAU - Casillas, Shannon M AU - Casillas SM AUID- ORCID: 0000-0001-7819-910X AD - Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. FAU - Chida, Asiya AU - Chida A AUID- ORCID: 0000-0002-5730-1934 AD - Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. FAU - Drobeniuc, Jan AU - Drobeniuc J AUID- ORCID: 0000-0002-0735-8115 AD - Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. FAU - Sandul, Amy L AU - Sandul AL AUID- ORCID: 0000-0002-7623-8408 AD - Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. FAU - Kamili, Saleem AU - Kamili S AD - Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. FAU - Jiles, Ruth B AU - Jiles RB AUID- ORCID: 0000-0002-7132-4008 AD - Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. FAU - Thomas, David L AU - Thomas DL AUID- ORCID: 0000-0002-0749-925X AD - Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. FAU - Tobian, Aaron A R AU - Tobian AAR AUID- ORCID: 0000-0002-0517-3766 AD - Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. FAU - Patel, Eshan U AU - Patel EU AUID- ORCID: 0000-0003-2174-5004 AD - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA. FAU - Teshale, Eyasu H AU - Teshale EH AUID- ORCID: 0000-0001-5244-8251 AD - Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. LA - eng GR - CC999999/ImCDC/Intramural CDC HHS/United States GR - US Centers for Disease Control and Prevention/ GR - HH/HHS/United States PT - Journal Article PL - United States TA - Clin Infect Dis JT - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JID - 9203213 RN - 0 (Hepatitis B Surface Antigens) RN - 0 (Hepatitis Antibodies) SB - IM MH - Humans MH - Seroepidemiologic Studies MH - *Hepatitis D/epidemiology/immunology MH - United States/epidemiology MH - Nutrition Surveys MH - *Hepatitis B Surface Antigens/blood/immunology MH - Female MH - Adolescent MH - Male MH - Child MH - Adult MH - Hepatitis Delta Virus/immunology MH - Middle Aged MH - *Hepatitis B/epidemiology/immunology MH - *Hepatitis Antibodies/blood MH - Young Adult MH - Aged PMC - PMC13572982 MID - NIHMS2208869 OTO - NOTNLM OT - hepatitis B OT - hepatitis D OT - seroprevalence COIS- Potential conflicts of interest. D. L. T. reports receipt of grants or contracts from the National Institutes of Health and Unitaid; consulting fees from Excision Bio; participation on a Data Safety Monitoring Board or Advisory Board for Merck and Rho; leadership role for the CROI Program Committee; and receipt of donated testing materials from Abbott Diagnostics. All other authors report no conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. EDAT- 2026/04/25 06:33 MHDA- 2026/10/07 17:33 PMCR- 2026/09/15 CRDT- 2026/04/25 04:13 PHST- 2026/02/04 00:00 [received] PHST- 2026/03/25 00:00 [accepted] PHST- 2026/10/07 17:33 [medline] PHST- 2026/04/25 06:33 [pubmed] PHST- 2026/04/25 04:13 [entrez] PHST- 2026/09/15 00:00 [pmc-release] AID - 8662345 [pii] AID - 10.1093/cid/ciag274 [doi] PST - ppublish SO - Clin Infect Dis. 2026 Oct 7;83(3):e530-e532. doi: 10.1093/cid/ciag274. PMID- 42029501 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260424 LR - 20260813 IS - 2411-5142 (Electronic) IS - 2411-5142 (Linking) VI - 11 IP - 2 DP - 2026 Mar 24 TI - Phase-Based Motor Skill Acquisition in Preschool Children with Different Participation Experience in a Kinesiology Program. LID - 10.3390/jfmk11020133 [doi] LID - 133 AB - Background: Early childhood is a critical period for the development of motor competence, which is closely related to later physical activity, educational readiness, and broader developmental outcomes. However, the temporal dynamics of motor skill acquisition in preschool children, particularly the time required to reach initial and early refinement phases of learning, remain insufficiently described. The aim of this study was to examine whether different levels of previous participation experience in an organized kinesiology program are associated with differences in the speed and quality of novel motor skill acquisition in preschool children, and to explore the relationship between baseline motor proficiency and phase-based indicators of motor learning. Methods: A total of 161 preschool children aged 5-6 years participated in the study and were grouped according to their previous participation experience in an organized kinesiology program (0 h, ~120 h, ~350 h, and ~470 h). Following BOT-2 assessment, all participants completed a standardized 7-week motor learning program that included nine previously unfamiliar motor tasks. Using a phase-based video analysis protocol, three learning indicators were recorded: time to Phase 1 (F1; first successful execution), time to Phase 2 (F2; initial refinement of performance), and final performance quality (K). Group differences and associations were first examined descriptively and correlationally, after which additional multivariable regression models were performed to determine whether previous participation experience and baseline motor proficiency were independently associated with motor learning outcomes. Results: The findings showed consistent differences across groups, with children who had greater previous participation experience generally reaching F1 and F2 more rapidly and achieving higher final performance quality scores. Higher BOT-2 scores were also associated with shorter learning times and better final performance quality. In the multivariable models, both previous participation experience in an organized kinesiology program and BOT-2 total score were independently associated with Phase 1 attainment time and final performance quality, whereas only previous participation experience remained independently associated with Phase 2 attainment time. The applied phase-based observational protocol demonstrated good to excellent inter-rater reliability across the evaluated motor learning variables. Conclusions: These findings provide phase-based temporal indicators of motor learning progression in preschool children and suggest that previous participation experience in an organized kinesiology program and baseline motor competence are meaningfully associated with the speed and quality of acquiring new motor tasks. The findings also demonstrate the potential of phase-based approaches for quantifying motor learning dynamics in early childhood settings. Such indicators may offer useful reference information for instructional pacing and the planning of motor learning activities, while also serving as practically relevant predictors for adapting future kinesiology programs to children's motor readiness. Future research should further examine these relationships using longitudinal and analytically expanded designs. FAU - Plazibat, Kristian AU - Plazibat K AUID- ORCID: 0000-0001-7957-5795 AD - Natural Sciences School Vladimir Prelog, 10000 Zagreb, Croatia. AD - Faculty of Educational Sciences, University of Slavonski Brod, 35000 Slavonski Brod, Croatia. AD - Faculty of Kinesiology, University of Zagreb, 10000 Zagreb, Croatia. FAU - Vidranski, Tihomir AU - Vidranski T AD - Faculty of Kinesiology, University of Zagreb, 10000 Zagreb, Croatia. FAU - Baric, Renata AU - Baric R AUID- ORCID: 0000-0003-2614-673X AD - Faculty of Kinesiology, University of Zagreb, 10000 Zagreb, Croatia. LA - eng PT - Journal Article DEP - 20260324 PL - Switzerland TA - J Funct Morphol Kinesiol JT - Journal of functional morphology and kinesiology JID - 101712257 PMC - PMC13108015 OTO - NOTNLM OT - motor competence OT - motor learning OT - organized kinesiology program OT - phase-based learning OT - preschool children COIS- The authors declare no conflicts of interest. EDAT- 2026/04/24 12:36 MHDA- 2026/04/24 12:37 PMCR- 2026/03/24 CRDT- 2026/04/24 10:43 PHST- 2026/01/30 00:00 [received] PHST- 2026/03/12 00:00 [revised] PHST- 2026/03/20 00:00 [accepted] PHST- 2026/04/24 12:37 [medline] PHST- 2026/04/24 12:36 [pubmed] PHST- 2026/04/24 10:43 [entrez] PHST- 2026/03/24 00:00 [pmc-release] AID - jfmk11020133 [pii] AID - jfmk-11-00133 [pii] AID - 10.3390/jfmk11020133 [doi] PST - epublish SO - J Funct Morphol Kinesiol. 2026 Mar 24;11(2):133. doi: 10.3390/jfmk11020133. PMID- 42027743 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260424 LR - 20260813 IS - 2667-3681 (Electronic) IS - 2667-3681 (Linking) VI - 18 DP - 2026 Jun TI - Association of front-of-package warning label perceptions with Mediterranean diet adherence after bariatric surgery: FOP perceptions and MedDiet adherence post-bariatric surgery. PG - 100266 LID - 10.1016/j.obpill.2026.100266 [doi] LID - 100266 AB - BACKGROUND: Front-of-package (FOP) warning labels are intended to support healthier food choices; however, evidence on how patients perceive these warnings after bariatric surgery and how such perceptions relate to dietary quality is limited. We examined the association between perceptions of FOP warning labels and Mediterranean diet (MedDiet) adherence among adults after bariatric surgery in Lima, Peru. METHODS: This was an observational, analytical, cross-sectional study of 200 adults (18-59 years) attending postoperative follow-up at a private clinic in Lima, Peru. MedDiet adherence was assessed using the KIDMED index (originally developed for children/adolescents and used here as a proxy measure of MedDiet-aligned behaviors), and perceptions/understanding of FOP octagonal warnings were measured using a previously validated Peruvian questionnaire. Associations were evaluated using bivariate analyses and multivariable logistic regression, reporting adjusted odds ratios (aOR) and 95% confidence intervals (CI). RESULTS: In adjusted models, higher self-reported preference for salty foods (aOR = 0.261; 95% CI: 0.136-0.501) and sweet foods (aOR = 0.490; 95% CI: 0.263-0.913) were associated with lower odds of medium/high MedDiet adherence. Greater agreement with the statement "I would follow the octagons, but nobody guides me on how to use them" was associated with higher odds of medium/high MedDiet adherence (aOR = 1.289; 95% CI: 1.002-1.659). CONCLUSION: Among adults after bariatric surgery, taste-preference indicators and perceptions regarding FOP warning labels were independently associated with MedDiet adherence. Given the cross-sectional design, these findings should be interpreted as associations rather than causal relationships and highlight the need to strengthen label literacy during postoperative nutrition education. CI - (c) 2026 The Authors. Published by Elsevier Inc. on behalf of Obesity Medicine Association. FAU - Milian, Sila Maribel Laboriano AU - Milian SML AD - Unidad de Salud Publica, Escuela de Posgrado, Universidad Peruana Union, Lima, Peru. FAU - Ruiz, Lesly Pamela Palomino AU - Ruiz LPP AD - Unidad de Salud Publica, Escuela de Posgrado, Universidad Peruana Union, Lima, Peru. FAU - Morales-Garcia, Wilter C AU - Morales-Garcia WC AD - Direccion General de Investigacion, Universidad Peruana Union, Lima, Peru. FAU - Calizaya-Milla, Yaquelin E AU - Calizaya-Milla YE AD - Research Group for Nutrition and Lifestyle, Escuela de Nutricion Humana, Facultad de ciencias de la Salud, Universidad Peruana Union, Lima, 15, Peru. LA - eng PT - Journal Article DEP - 20260414 PL - United States TA - Obes Pillars JT - Obesity pillars JID - 9918697364706676 PMC - PMC13101637 OTO - NOTNLM OT - Bariatric surgery OT - Dietary adherence OT - Front-of-package warning labels OT - Mediterranean diet OT - Obesity COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/24 12:20 MHDA- 2026/04/24 12:21 PMCR- 2026/04/14 CRDT- 2026/04/24 04:50 PHST- 2025/12/01 00:00 [received] PHST- 2026/04/10 00:00 [revised] PHST- 2026/04/10 00:00 [accepted] PHST- 2026/04/24 12:21 [medline] PHST- 2026/04/24 12:20 [pubmed] PHST- 2026/04/24 04:50 [entrez] PHST- 2026/04/14 00:00 [pmc-release] AID - S2667-3681(26)00022-7 [pii] AID - 100266 [pii] AID - 10.1016/j.obpill.2026.100266 [doi] PST - epublish SO - Obes Pillars. 2026 Apr 14;18:100266. doi: 10.1016/j.obpill.2026.100266. eCollection 2026 Jun. PMID- 42027723 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260424 LR - 20260813 IS - 1178-7007 (Print) IS - 1178-7007 (Electronic) IS - 1178-7007 (Linking) VI - 19 DP - 2026 TI - Vitamin D Metabolite Ratios and Association with Type 2 Diabetes Mellitus in a Youth Saudi Population. PG - 597635 LID - 10.2147/DMSO.S597635 [doi] LID - 597635 AB - PURPOSE: Vitamin D deficiency is highly prevalent in Saudi Arabia and has been associated with type 2 diabetes mellitus (T2DM). The vitamin D metabolite ratio (VMR), defined as the ratio of 24,25-dihydroxyvitamin D(3) [24,25(OH)(2)D(3)] to 25-hydroxyvitamin D(3) [25(OH)D(3)], may provide a more functional assessment of vitamin D status than total 25(OH)D alone. This study aimed to investigate the associations between vitamin D metabolite ratio and T2DM status in a Saudi youth cohort. PATIENTS AND METHODS: A cross-sectional study was conducted involving 971 Saudi adolescents (age 14.9 +/- 1.7 years), including 864 normoglycemic individuals, 74 with prediabetes, and 33 with T2DM. Serum vitamin D metabolites [25(OH)D(3), 24,25(OH)(2)D(3), and 25(OH)D(2)] were measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The vitamin D metabolite ratio was calculated, and its association with T2DM was assessed using logistic regression analysis adjusted for age and body mass index (BMI). VMR was analyzed both as a continuous variable and dichotomized at <4% versus >/=4%. The 4% threshold was selected based on preliminary data from adult populations and exploratory analysis of our data distribution, recognizing that this threshold requires validation in adolescent cohorts. RESULTS: Lower VMR (<4%) was associated with higher odds of T2DM (OR: 4.7, 95% CI: 1.1-20.0, p = 0.036), though the wide confidence interval reflects the small T2DM sample size (n=33). Preliminary analysis indicated that VMR may be associated with T2DM in Saudi adolescents, but findings should be interpreted cautiously given the small T2DM sample and cross-sectional design. Larger prospective studies are needed to confirm these preliminary observations. CONCLUSION: A lower vitamin D metabolite ratio is associated with T2DM among Saudi adolescents. VMR may provide complementary information beyond total 25(OH)D; however, formal comparative predictive analyses were not performed, underscoring the importance of proper vitamin D metabolism in glucose homeostasis. However, given the cross-sectional design and small T2DM sample size, these findings are preliminary and require validation in larger prospective studies. CI - (c) 2026 Yakout et al. FAU - Yakout, Sobhy M AU - Yakout SM AD - Chair for Biomarkers of Chronic Diseases, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia. FAU - Hussain, Syed D AU - Hussain SD AD - Chair for Biomarkers of Chronic Diseases, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia. FAU - Alnaami, Abdullah M AU - Alnaami AM AD - Chair for Biomarkers of Chronic Diseases, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia. FAU - Al-Daghri, Nasser M AU - Al-Daghri NM AUID- ORCID: 0000-0001-5472-1725 AD - Chair for Biomarkers of Chronic Diseases, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260418 PL - New Zealand TA - Diabetes Metab Syndr Obes JT - Diabetes, metabolic syndrome and obesity : targets and therapy JID - 101515585 PMC - PMC13101821 OTO - NOTNLM OT - LC-MS/MS OT - glucose dysregulation OT - impaired fasting glucose OT - vitamin D hydroxylation OT - vitamin D metabolism OT - youth population COIS- The author(s) report no conflicts of interest in this work. EDAT- 2026/04/24 12:20 MHDA- 2026/04/24 12:21 PMCR- 2026/04/18 CRDT- 2026/04/24 04:49 PHST- 2026/01/28 00:00 [received] PHST- 2026/03/24 00:00 [accepted] PHST- 2026/04/24 12:21 [medline] PHST- 2026/04/24 12:20 [pubmed] PHST- 2026/04/24 04:49 [entrez] PHST- 2026/04/18 00:00 [pmc-release] AID - 597635 [pii] AID - 10.2147/DMSO.S597635 [doi] PST - epublish SO - Diabetes Metab Syndr Obes. 2026 Apr 18;19:597635. doi: 10.2147/DMSO.S597635. eCollection 2026. PMID- 42027561 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260424 LR - 20260921 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Reducing relapse in children after recovery from severe acute malnutrition in Mali: participatory development of a theory of change for post-treatment monitoring including SQ-LNS supplementation. PG - 1765714 LID - 10.3389/fnut.2026.1765714 [doi] LID - 1765714 AB - INTRODUCTION: Up to 76% of children treated for acute malnutrition relapse within 6 months from discharge. Despite its known negative impact on children's health and the drain on health system's scarce resources, few studies have explored ways to reduce relapse. In order to design an intervention that can work, there is a need to thoroughly understand the drivers of relapse in a context. OBJECTIVE: We aimed to develop a robust theory of change (ToC) for how relapse can be reduced in Mali and propose an intervention package that is feasible for the health system to adopt with minimal external support. METHODS: We applied a four-step approach to develop the ToC including: (1) An evidence review of potential drivers of malnutrition and relapse locally, based on surveys, gray literature and scientific articles, (2) Schematization of the most important immediate and underlying causes of relapse based on step 1 in a problem tree style and development of a ToC for a program that aims to address the causes, (3) Validation of the ToC with local stakeholders, and (4) Identification of facilitators, barriers and assumptions. Most work was done through on-line workshops including participants from local Ministry of Health (MoH), a local university (USTTB) and both global and local IRC nutrition staff. One in-person workshop was organized with local stakeholders from technical partners and different levels of local health authorities to finalize the ToC. RESULTS: Three direct causes of relapse were identified: (1) Inadequate initial treatment, (2) Inadequate dietary intake post-discharge, and (3) Frequent illness episodes combined with inadequate treatment seeking. To reduce relapse post-treatment, three aims were identified: (1) Improving initial acute malnutrition treatment, (2) Improving nutritional intake after discharge, (3) Decreasing incidence of illness and increasing use of health services. The proposed intervention was built around a program for the post-treatment monitoring of children at the treatment sites including health checks and the provision of small-quantity lipid-based nutrient supplements for children. Inputs included initial and on-going training, supplies and equipment, and supervision and coordination. CONCLUSION: The development of a comprehensive ToC to prevent relapse allowed us to design an intervention that tackles the key perceived and evidenced drivers of relapse in the context. This ToC will underpin a process evaluation that will need to accompany an impact evaluation to determine if and how the intervention reduces relapse. CI - Copyright (c) 2026 Kangas, Coulibaly, Diassana, Traore, Haidara, Cichon, Kodish and Heymsfield. FAU - Kangas, Suvi T AU - Kangas ST AD - International Rescue Committee, Brussels, Belgium. FAU - Coulibaly, Issa Niamanto AU - Coulibaly IN AD - International Rescue Committee, Bamako, Mali. FAU - Diassana, Koniba AU - Diassana K AD - International Rescue Committee, Bamako, Mali. FAU - Traore, Mamadou Zie AU - Traore MZ AD - International Rescue Committee, Bamako, Mali. FAU - Haidara, Alhousseyni AU - Haidara A AD - International Rescue Committee, Bamako, Mali. FAU - Cichon, Bernardette AU - Cichon B AD - International Rescue Committee, London, United Kingdom. FAU - Kodish, Stephen R AU - Kodish SR AD - Pennsylvanla State University, University Park, PA, United States. FAU - Heymsfield, Grace AU - Heymsfield G AD - International Rescue Committee, New York, NY, United States. LA - eng PT - Journal Article DEP - 20260408 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 EIN - Front Nutr. 2026 May 12;13:1863256. doi: 10.3389/fnut.2026.1863256. PMID: 42206088 PMC - PMC13099773 OTO - NOTNLM OT - Mali OT - SQ-LNS small-quantity lipid-based nutrient supplements OT - acute malnutrition OT - relapse OT - severe acute malnutrition (SAM) OT - theory of change (ToC) COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/24 12:20 MHDA- 2026/04/24 12:21 PMCR- 2026/04/08 CRDT- 2026/04/24 04:47 PHST- 2025/12/11 00:00 [received] PHST- 2026/03/13 00:00 [revised] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/04/24 12:21 [medline] PHST- 2026/04/24 12:20 [pubmed] PHST- 2026/04/24 04:47 [entrez] PHST- 2026/04/08 00:00 [pmc-release] AID - 10.3389/fnut.2026.1765714 [doi] PST - epublish SO - Front Nutr. 2026 Apr 8;13:1765714. doi: 10.3389/fnut.2026.1765714. eCollection 2026. PMID- 42023462 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260826 IS - 1578-2735 (Electronic) IS - 1139-9287 (Print) IS - 1139-9287 (Linking) VI - 54 IP - 2 DP - 2026 Apr 15 TI - Impact of the Interaction Between Screen Time and Activity Interests on Adolescent Depression Risk: Construction of a Predictive Model Based on Machine Learning. PG - 500-515 LID - 10.62641/aep.v54i2.2068 [doi] AB - BACKGROUND: Adolescent depression is an increasing public health concern, with excessive screen time elevating depression risk and activity interests providing protection. However, most studies examine these behaviors separately and rely on limited analytical methods. This study used machine learning (ML) to develop a predictive model and evaluate the combined influence of screen time and activity interests on adolescent mental health. METHODS: A multi-center survey was conducted among adolescents aged 10-14 years in Chongchuan District, Nantong. Depression-related domains were assessed using the Child and Adolescent Mental Health Screening Questionnaire, integrating seven validated scales. A twostage feature-selection strategy identified 11 key predictors. Three ML models (logistic regression [LR], extreme gradient boosting [XGBoost], and categorical boosting [CatBoost]) were trained with an 80:20 stratified split. Class imbalance was addressed using synthetic minority oversampling technique and class-weighting. Model performance and interpretability were evaluated using receiver operating characteristic (ROC) and calibration curves, partial dependence plots, and shapley additive explanations (SHAP) analyses. RESULTS: A total of 2202 valid questionnaires were analyzed. The distribution of depression severity was as follows: safe 59%, mild 17%, moderate 11%, and severe 13%. The integrated questionnaire demonstrated strong reliability (Cronbach's alpha = 0.910) and good construct validity (Kaiser-Meyer-Olkin [KMO] = 0.91; root mean square error of approximation [RMSEA] = 0.049; and comparative fit index [CFI] = 0.859). ROC-Youden analysis confirmed expert-defined cutoffs (29, 32, and 35). Feature selection identified 11 key predictors, with activity interest and psychological functioning consistently ranking highest in importance. Across the three ML models, LR exhibited the best generalizability, XGBoost showed overfitting, and CatBoost achieved balanced performance. SHAP and partial dependence analyses revealed nonlinear screen-time effects and dose-dependent protective effects of activity interest, including the moderation of high screen exposure in severe-risk groups. CONCLUSIONS: This study suggests that ML models can be used to screen adolescents at risk of depression by capturing the combined influence of screen time and activity interests. The model is intended for screening rather than diagnosis and may support school-based early identification, and further validation in clinical contexts is needed. FAU - Mao, Leiming AU - Mao L AD - Nantong Mental Health Center, 226001 Nantong, Jiangsu, China. FAU - He, Ruiqi AU - He R AD - Department of Medical Informatics, School of Medicine, Nantong University, 226001 Nantong, Jiangsu, China. FAU - Zhang, Shike AU - Zhang S AD - Department of Medical Informatics, School of Medicine, Nantong University, 226001 Nantong, Jiangsu, China. FAU - Ge, Yongqian AU - Ge Y AD - Department of Radiology, Affiliated Hospital of Nantong University, 226001 Nantong, Jiangsu, China. FAU - Xu, Entong AU - Xu E AD - Department of Medical Informatics, School of Medicine, Nantong University, 226001 Nantong, Jiangsu, China. FAU - Chen, Yalan AU - Chen Y AD - Department of Medical Informatics, School of Medicine, Nantong University, 226001 Nantong, Jiangsu, China. FAU - Cong, Gujun AU - Cong G AD - Nantong Mental Health Center, 226001 Nantong, Jiangsu, China. FAU - Miao, Haiyan AU - Miao H AD - Nantong Mental Health Center, 226001 Nantong, Jiangsu, China. FAU - Jiang, Yunjie AU - Jiang Y AD - Nantong Mental Health Center, 226001 Nantong, Jiangsu, China. FAU - Zhu, Haijiao AU - Zhu H AD - Nantong Mental Health Center, 226001 Nantong, Jiangsu, China. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260415 PL - Spain TA - Actas Esp Psiquiatr JT - Actas espanolas de psiquiatria JID - 100886502 SB - IM MH - Humans MH - Predictive Learning Models MH - Adolescent MH - *Depression/epidemiology/etiology/diagnosis MH - *Screen Time MH - Female MH - Child MH - Male MH - *Machine Learning MH - Boosting Machine Learning Algorithms MH - Prediction Algorithms PMC - PMC13180681 COIS- The authors declare no conflict of interest. EDAT- 2026/04/23 06:31 MHDA- 2026/04/23 06:32 PMCR- 2026/04/15 CRDT- 2026/04/23 05:32 PHST- 2026/04/23 06:32 [medline] PHST- 2026/04/23 06:31 [pubmed] PHST- 2026/04/23 05:32 [entrez] PHST- 2026/04/15 00:00 [pmc-release] AID - 10.62641/aep.v54i2.2068 [pii] AID - 10.62641/aep.v54i2.2068 [doi] PST - epublish SO - Actas Esp Psiquiatr. 2026 Apr 15;54(2):500-515. doi: 10.62641/aep.v54i2.2068. PMID- 42022686 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260423 LR - 20260813 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 3 DP - 2026 Mar TI - Critical Evaluation of the Impact of COVID-19 Pandemic on Child Health and Wellbeing and Suggested Preparedness for Future Pandemics-A Narrative Review. PG - e72073 LID - 10.1002/hsr2.72073 [doi] LID - e72073 AB - BACKGROUND AND AIMS: The immediate and long-term effects of COVID-19 pandemic on the children go beyond just being a viral infection. A child's mental health and psychological issues like irritability, anxiety, sadness, non-attentiveness, attention deficit and hyperactive disorder needed evaluation. Based on these study queries, an investigation was carried out to correlate the psychological state and the emergency measures in children with respect to the health and wellbeing outcomes. METHODS: A web-search across scientific databases like the Web of Science, Scopus and PubMed was undertaken for a situational review through available literature, and derive credible solutions. This narrative review included peer-reviewed articles published between January 2020 and February 2026 in English language, focusing on children wellbeing in wake of the COVID-19 pandemic. After analysing the authenticity and relevance of the literature, 158 articles/data were shortlisted for further analyses. The data were qualitatively validated, synthesised into discrete sections and interpreted in the context of the objective of the study. RESULT: Children particularly in low-economy families were likely to experience violence and abuse if they stayed for long in high-risk settings like refugee settlements for internally displaced community. On the contrary, the children of high-economy families had weight gain issues owing to erratic consumption patterns of high-calorie food (like dairy products and sugar-rich packaged snacks) coupled with restricted or limited physical activities. Their dietary patterns and unhealthy eating habits needed monitoring and restrictions to curb obesity risk in the long run. Elevated stress, anxiety and depression levels in a child may result in cognitive impairment. The possibilities of their getting addicted, developing insomnia and acquiring non-communicable illnesses were aspects to consider. Preventive measures like social distancing, lockdowns and shutdowns and mass vaccination drives had wider and critical long-term impact on the young and adolescent. Formulating workable modalities to identify critical influencing factors of a pandemic and assess the impact on the children and beyond is essential for foolproof solutions to combat future occurrences. CONCLUSION: Identifying the associated risk factors and correlating the emergency measures and psychological health seem essential. The supply of quality food seamlessly to the affected communities and the provision of protective gears for the healthcare workers could help keep the children well-fed and relaxed while ensuring the wellbeing of healthcare workers. Maternal and infant care, child-health services, and life-saving medicines and vaccines would also help ease the pressure. CI - (c) 2026 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Mohapatra, Ranjan K AU - Mohapatra RK AUID- ORCID: 0000-0001-7623-3343 AD - Department of Chemistry Government College of Engineering Keonjhar Odisha India. FAU - Sarangi, Ashish K AU - Sarangi AK AUID- ORCID: 0000-0002-5602-4736 AD - Department of Chemistry, School of Applied Sciences Centurion University of Technology and Management R. Sitapur India. FAU - Pattnaik, Gurudutta AU - Pattnaik G AD - School of Pharmacy and Life Sciences Centurion University of Technology and Management R. Sitapur India. FAU - Singh, Puneet K AU - Singh PK AUID- ORCID: 0000-0003-1424-7648 AD - School of Biotechnology, Campus-11 KIIT Deemed-to-be-University Bhubaneswar Odisha India. FAU - Dash, Rasmita AU - Dash R AD - School of Pharmacy and Life Sciences Centurion University of Technology and Management R. Sitapur India. FAU - Kandi, Venkataramana AU - Kandi V AUID- ORCID: 0000-0002-7197-0448 AD - Department of Microbiology Prathima Institute of Medical Sciences Karimnagar Telangana India. FAU - Kutikuppala, L V Simhachalam AU - Kutikuppala LVS AD - Department of General Surgery Dr NTR University of Health Sciences Vijayawada Andhra Pradesh India. FAU - Sahoo, Rudra Narayan AU - Sahoo RN AD - School of Pharmaceutical Sciences Siksha O Anusandhan (Deemed to be University) Bhubaneswar Odisha India. FAU - Mishra, Snehasish AU - Mishra S AUID- ORCID: 0009-0008-2139-0075 AD - School of Biotechnology, Campus-11 KIIT Deemed-to-be-University Bhubaneswar Odisha India. FAU - Mishra, Anita AU - Mishra A AD - QA Lead India RASA AI, ChatOwl Inc. 201 Spear Street, Suite 1100 San Francisco California USA. FAU - Nasker, Sourya Subhra AU - Nasker SS AUID- ORCID: 0000-0002-5020-5595 AD - School of Biotechnology, Campus-11 KIIT Deemed-to-be-University Bhubaneswar Odisha India. FAU - Nayak, Sasmita AU - Nayak S AUID- ORCID: 0000-0002-8663-5802 AD - School of Biotechnology, Campus-11 KIIT Deemed-to-be-University Bhubaneswar Odisha India. FAU - Alrasheed, Hayam A AU - Alrasheed HA AUID- ORCID: 0009-0002-6186-848X AD - Department of Pharmacy Practice, College of Pharmacy Princess Nourah Bint Abdulrahman University Riyadh Saudi Arabia. FAU - Kaabi, Nawal A Al AU - Kaabi NAA AD - College of Medicine and Health Science Khalifa University Abu Dhabi United Arab Emirates. AD - Sheikh Khalifa Medical City, Abu Dhabi Health Services Company (SEHA) Abu Dhabi United Arab Emirates. FAU - Alshengeti, Amer AU - Alshengeti A AD - Department of Pediatrics, College of Medicine Taibah University Al-Madinah Saudi Arabia. AD - Department of Infection Prevention and Control, Prince Mohammad Bin Abdulaziz Hospital National Guard Health Affairs Al-Madinah Saudi Arabia. FAU - Abdulkhaliq, Altaf A AU - Abdulkhaliq AA AUID- ORCID: 0000-0002-8148-1103 AD - Department of Biochemistry, Faculty of Medicine Umm Al-Qura University Makkah Saudi Arabia. FAU - Rabaan, Ali A AU - Rabaan AA AUID- ORCID: 0000-0002-6774-9847 AD - Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare Dhahran Saudi Arabia. AD - College of Medicine Alfaisal University Riyadh Saudi Arabia. AD - Department of Public Health and Nutrition The University of Haripur Haripur Pakistan. FAU - Al-Subaie, Maha F AU - Al-Subaie MF AD - College of Medicine Alfaisal University Riyadh Saudi Arabia. AD - Research Center, Dr. Sulaiman Alhabib Medical Group Riyadh Saudi Arabia. FAU - Alhumaid, Saad AU - Alhumaid S AD - School of Pharmacy University of Tasmania Hobart Australia. FAU - Dhama, Kuldeep AU - Dhama K AD - Division of Pathology, ICAR-Indian Veterinary Research Institute Bareilly Uttar Pradesh India. FAU - Kudrat-E-Zahan, Md AU - Kudrat-E-Zahan M AUID- ORCID: 0000-0001-8159-5293 AD - Department of Chemistry Rajshahi University Rajshahi Bangladesh. LA - eng PT - Journal Article DEP - 20260317 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC13098172 OTO - NOTNLM OT - COVID-19 OT - COVID-associated complication OT - child nutrition OT - children OT - mental health OT - yoga COIS- The authors declare no conflicts of interest. EDAT- 2026/04/23 06:32 MHDA- 2026/04/23 06:33 PMCR- 2026/03/17 CRDT- 2026/04/23 05:13 PHST- 2024/09/11 00:00 [received] PHST- 2026/02/20 00:00 [revised] PHST- 2026/03/05 00:00 [accepted] PHST- 2026/04/23 06:33 [medline] PHST- 2026/04/23 06:32 [pubmed] PHST- 2026/04/23 05:13 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - HSR272073 [pii] AID - 10.1002/hsr2.72073 [doi] PST - epublish SO - Health Sci Rep. 2026 Mar 17;9(3):e72073. doi: 10.1002/hsr2.72073. eCollection 2026 Mar. PMID- 42021356 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260813 IS - 1476-511X (Electronic) IS - 1476-511X (Linking) VI - 25 IP - 1 DP - 2026 Apr 22 TI - Untargeted plasma lipidomic profiling associated with pediatric metabolic dysfunction-associated steatohepatitis (MASH). LID - 10.1186/s12944-026-02937-y [doi] LID - 144 AB - BACKGROUND: Altered lipid metabolism is central to the pathogenesis of MASH, yet lipidomic data in pediatric populations are limited. We conducted a cross-sectional analysis using high-resolution lipidomics to identify lipid alterations associated with pediatric MASH in youth enrolled in NASH CRN studies. METHODS: Clinical assessments included anthropometrics, lipid panels, liver enzymes, and markers of glucose metabolism. MASLD status was determined by liver biopsy or MRI-PDFF. Plasma untargeted lipidomics was performed using UHPLC-MS/MS. Linear models identified differentially abundant lipids. Network analysis characterized lipid-clinical associations and identified network-informed central lipids to evaluate MASH classification performance. RESULTS: The cohort included 102 participants with MASH (29% Zone 1, 19% Zone 3, 52% Definite) and 58 non-MASH participants (29 MASL and 29 controls). Participants were aged 7-18 years; 77% were male and 58% Hispanic, with a mean BMI Z-score of 2.01 +/- 0.77. Compared with non-MASH participants, those with MASH had higher BMI Z-scores, waist circumference, liver enzymes, insulin resistance markers, and triglycerides, and lower HDL cholesterol (p < 0.05). Lipidomics analysis revealed higher levels of saturated TG species and lower levels of Cer and SM species in participants with MASH (p < 0.05). Network analysis showed greater centrality of insulin resistance markers (fasting insulin, HOMA-IR) among participants with MASH, whereas non-MASH participant networks exhibited broader lipid-clinical connectivities. Adding central lipids [TG(12:0_16:0_18:2), SM(d32:3), TG(50:5)] with a high Eigenvector Centrality Score (ECS) significantly improved MASH classification performance. CONCLUSIONS: Pediatric MASH was associated with plasma lipid remodeling, and network-derived central lipids improved MASH classification performance. These findings highlight the potential of lipid signatures for the noninvasive diagnosis of pediatric MASH and warrant validation in independent, longitudinal cohorts. FAU - Lim, Gahyun AU - Lim G AD - Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, USA. FAU - Huneault, Helaina E AU - Huneault HE AD - Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, USA. AD - Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, Grand Rapids, MI, USA. FAU - Chen, Chih-Yu AU - Chen CY AD - Emory Integrated Metabolomics and Lipidomics Core, Emory University, Atlanta, GA, USA. FAU - Won, Grey AU - Won G AD - Emory Integrated Metabolomics and Lipidomics Core, Emory University, Atlanta, GA, USA. FAU - Sanchez-Torres, Cristian AU - Sanchez-Torres C AD - Department of Pediatrics, Emory University, Atlanta, GA, USA. FAU - Maner-Smith, Kristal AU - Maner-Smith K AD - Emory Integrated Metabolomics and Lipidomics Core, Emory University, Atlanta, GA, USA. FAU - Vos, Miriam B AU - Vos MB AD - Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, USA. miriam.vos@msu.edu. AD - Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, Grand Rapids, MI, USA. miriam.vos@msu.edu. AD - Department of Pediatrics, Emory University, Atlanta, GA, USA. miriam.vos@msu.edu. AD - Children's Healthcare of Atlanta, Atlanta, GA, USA. miriam.vos@msu.edu. AD - Helen DeVos Children's Hospital, Corewell Health, Grand Rapids, MI, USA. miriam.vos@msu.edu. AD - Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, Helen DeVos Children's Hospital at Corewell Health, Grand Rapids, MI, USA. miriam.vos@msu.edu. LA - eng PT - Journal Article DEP - 20260422 PL - England TA - Lipids Health Dis JT - Lipids in health and disease JID - 101147696 RN - 0 (Lipids) RN - 0 (Triglycerides) RN - 0 (Biomarkers) RN - 0 (Cholesterol, HDL) SB - IM MH - Humans MH - Male MH - Child MH - *Lipidomics/methods MH - Adolescent MH - Female MH - *Non-alcoholic Fatty Liver Disease/blood/pathology MH - Cross-Sectional Studies MH - Liver/pathology/metabolism MH - *Lipids/blood MH - Lipid Metabolism/genetics MH - Insulin Resistance MH - Triglycerides/blood MH - Biomarkers/blood MH - Cholesterol, HDL/blood MH - Tandem Mass Spectrometry PMC - PMC13235174 OTO - NOTNLM OT - Insulin Resistance OT - Lipidomics OT - Pediatric MASH OT - TG COIS- Declarations. Ethics approval and consent to participate: All participants provided written informed consent and assent for their samples and data to be used for future research. The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Boards of Emory University (Protocol No. 78513) and University of California San Diego (Protocol No. 150741). Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/23 06:32 MHDA- 2026/06/28 10:10 PMCR- 2026/04/22 CRDT- 2026/04/23 00:55 PHST- 2025/12/10 00:00 [received] PHST- 2026/03/21 00:00 [accepted] PHST- 2026/06/28 10:10 [medline] PHST- 2026/04/23 06:32 [pubmed] PHST- 2026/04/23 00:55 [entrez] PHST- 2026/04/22 00:00 [pmc-release] AID - 10.1186/s12944-026-02937-y [pii] AID - 2937 [pii] AID - 10.1186/s12944-026-02937-y [doi] PST - epublish SO - Lipids Health Dis. 2026 Apr 22;25(1):144. doi: 10.1186/s12944-026-02937-y. PMID- 42019912 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260730 IS - 1876-2867 (Electronic) IS - 1876-2859 (Linking) VI - 26 IP - 5 DP - 2026 Jul TI - Cardiovascular risk factors and health-related social needs among youth in a largely rural health system. PG - 103331 LID - S1876-2859(26)00113-0 [pii] LID - 10.1016/j.acap.2026.103331 [doi] AB - OBJECTIVE: To describe the relationship between cardiovascular disease (CVD) risk factors and health-related social needs (HRSN) among youth 6 to 17 years receiving care in a primarily rural health system. METHODS: Cross-sectional study of patients 6 to 17 years who were eligible for a pragmatic, cluster-randomized clinical trial. Patients with a blood pressure (BP) measurement at a primary care visit between August 1, 2022 to July 31, 2023 were included. Primary measures were CVD risk factors, identified through diagnoses, problem lists and clinical data, and the presence of one or more HRSN as reported in a validated questionnaire. Contingency tables and logistic regression analyses were used to quantify associations between CVD risk factors and HRSN. RESULTS: A total of 33,192 patients (mean 11.6 years, 49.6% male, 55.3% rural) were included. Smoking, obesity, and BP were routinely assessed, while diabetes and dyslipidemia were evaluated in a subset. Thirty-five percent had at least 1 CVD risk factor. Obesity (21.0%) and smoking or passive smoke exposure (16.8%) occurred frequently, while diabetes or prediabetes (3.0%) and hypertension or hypertensive level blood pressure (2.3%) were infrequent. Financial strain (4.0%), food worry (3.3%), and food insecurity (2.4%) were the most often reported HRSN. Having an HRSN was associated with CVD risk factors, including smoking (adjusted odds ratio [aOR]: 2.59; 95% confidence interval [CI]: 2.25-2.99), diabetes or prediabetes (aOR, 1.57; 95% CI: 1.01-2.43), and obesity (aOR, 1.63; 95% CI: 1.41-1.88). CONCLUSIONS: We found a high proportion of youth with increased CVD risk. Self-reported HRSN were associated with CVD risk factors, including smoking, diabetes or prediabetes, and obesity. CI - Copyright (c) 2026 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved. FAU - Benziger, Catherine P AU - Benziger CP AD - Essentia Health Heart and Vascular Center (CP Benziger), Duluth, Minn. FAU - Schultz, Brandon J AU - Schultz BJ AD - University of Minnesota Medical School - Duluth Campus (BJ Schultz), Duluth, Minn. FAU - Harry, Melissa L AU - Harry ML AD - Essentia Institute of Rural Health (ML Harry, CI Allen, and LA Freitlag), Duluth, Minn. FAU - Allen, Clayton I AU - Allen CI AD - Essentia Institute of Rural Health (ML Harry, CI Allen, and LA Freitlag), Duluth, Minn. FAU - Freitag, Laura A AU - Freitag LA AD - Essentia Institute of Rural Health (ML Harry, CI Allen, and LA Freitlag), Duluth, Minn. FAU - Asche, Stephen E AU - Asche SE AD - HealthPartners Institute (SE Asche, HL Ekstrom, IJ Essien, PJ O'Connor, and EO Kharbanda), Bloomington, Minn. FAU - Ekstrom, Heidi L AU - Ekstrom HL AD - HealthPartners Institute (SE Asche, HL Ekstrom, IJ Essien, PJ O'Connor, and EO Kharbanda), Bloomington, Minn. FAU - Essien, Inih J AU - Essien IJ AD - HealthPartners Institute (SE Asche, HL Ekstrom, IJ Essien, PJ O'Connor, and EO Kharbanda), Bloomington, Minn. FAU - Saman, Daniel M AU - Saman DM AD - Consultant (DM Saman), Lexington, Ky. FAU - O'Connor, Patrick J AU - O'Connor PJ AD - HealthPartners Institute (SE Asche, HL Ekstrom, IJ Essien, PJ O'Connor, and EO Kharbanda), Bloomington, Minn. FAU - Kharbanda, Elyse O AU - Kharbanda EO AD - HealthPartners Institute (SE Asche, HL Ekstrom, IJ Essien, PJ O'Connor, and EO Kharbanda), Bloomington, Minn. Electronic address: Elyse.o.kharbanda@healthpartners.com. LA - eng PT - Journal Article PT - Pragmatic Clinical Trial PT - Randomized Controlled Trial DEP - 20260420 PL - United States TA - Acad Pediatr JT - Academic pediatrics JID - 101499145 RN - 0 (Tobacco Smoke Pollution) SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Cardiovascular Diseases/epidemiology MH - Cross-Sectional Studies MH - Diabetes Mellitus/epidemiology MH - Dyslipidemias/epidemiology MH - Food Insecurity MH - *Heart Disease Risk Factors MH - Hypertension/epidemiology MH - Obesity/epidemiology MH - Risk Factors MH - Rural Population MH - Smoking/epidemiology MH - Tobacco Smoke Pollution/statistics & numerical data OTO - NOTNLM OT - health-related social needs OT - obesity OT - risk factors OT - smoking COIS- Declaration of Competing Interest The authors have no conflicts of interest to disclose. EDAT- 2026/04/23 00:32 MHDA- 2026/07/09 00:40 CRDT- 2026/04/22 19:17 PHST- 2025/07/14 00:00 [received] PHST- 2026/04/13 00:00 [revised] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/07/09 00:40 [medline] PHST- 2026/04/23 00:32 [pubmed] PHST- 2026/04/22 19:17 [entrez] AID - S1876-2859(26)00113-0 [pii] AID - 10.1016/j.acap.2026.103331 [doi] PST - ppublish SO - Acad Pediatr. 2026 Jul;26(5):103331. doi: 10.1016/j.acap.2026.103331. Epub 2026 Apr 20. PMID- 42018794 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2317-1782 (Electronic) IS - 2317-1782 (Linking) VI - 38 IP - 3 DP - 2026 TI - Reliability between measurements obtained by caliper and digital photography in facial anthropometry. PG - e20250193 LID - S2317-17822026000300606 [pii] LID - 10.1590/2317-1782/e20250193pt [doi] LID - e20250193 AB - PURPOSE: To investigate the reliability between direct and indirect measurements in facial anthropometry. METHODS: The sample consisted of 60 subjects aged between 16 and 48 years. After applying the eligibility criteria, indirect objective anthropometric facial examinations (SAPO(R) and IMAGEJ(R) software) and direct frontal anthropometric examinations were performed using a digital caliper at the anthropometric points: glabella, sub nasale, gnathion, alar, exocanthus, and chilling, with the patients seated in a comfortable position and head in a natural position. Two trained and calibrated examiners performed the measurements three times to obtain the arithmetic mean. The participants were photographed to perform the indirect measurements. The results were analyzed using descriptive statistics (measures of absolute and relative frequency and summary measures of central tendency and dispersion) and inferential statistics (Chi-square test, Bland-Altman, paired t-test, and Intraclass Correlation Coefficient), considering a significance of 5%. RESULTS: There was intra- and inter-observer agreement, sexual dimorphism (female measurements smaller), higher values of direct anthropometry when compared with photoanthropometry, and differences between the software used and the caliper with ImageJ(R). CONCLUSION: There was a divergence between direct and indirect anthropometries, which do not represent the same values and proportions, depending on the anthropometric point used, and the professional should consider this aspect. Facial anthropometric comparisons should be carried out using the same software in order to avoid divergences in analyses. FAU - Andrade, Rayssa Silva Santos AU - Andrade RSS AUID- ORCID: 0009-0003-1090-0950 AD - Departamento de Fonoaudiologia, Universidade Federal de Sergipe - UFS - Sao Cristovao (SE), Brasil. FAU - Matos, Paulo Vitor de Oliveira Santos AU - Matos PVOS AUID- ORCID: 0009-0004-0587-8522 AD - Departamento de Fonoaudiologia, Universidade Federal de Sergipe - UFS - Sao Cristovao (SE), Brasil. FAU - Rehder, Maria Ines Beltrati Cornacchioni AU - Rehder MIBC AUID- ORCID: 0000-0002-4416-6075 AD - Pos-graduacao em Pericia Fonoaudiologica, CEFAC - Saude Educacao - Rio Claro (SP), Brasil. AD - Parole Fonoaudiologia Clinico Cientifica - Rio Claro (SP), Brasil. FAU - Guedes-Granzotti, Raphaela Barroso AU - Guedes-Granzotti RB AUID- ORCID: 0000-0002-9064-439X AD - Departamento de Fonoaudiologia, Universidade Federal de Sergipe - UFS - Sao Cristovao (SE), Brasil. FAU - Silva, Kelly da AU - Silva KD AUID- ORCID: 0000-0002-9193-7282 AD - Departamento de Fonoaudiologia, Universidade Federal de Sergipe - UFS - Lagarto (SE), Brasil. FAU - Cesar, Carla Patricia Hernandez Alves Ribeiro AU - Cesar CPHAR AUID- ORCID: 0000-0002-9439-9352 AD - Departamento de Fonoaudiologia, Universidade Federal de Sergipe - UFS - Sao Cristovao (SE), Brasil. LA - por LA - eng PT - Journal Article TT - Confiabilidade entre as medidas obtidas pelo paquimetro e por fotografia digital na antropometria facial. DEP - 20260420 PL - Brazil TA - Codas JT - CoDAS JID - 101623246 SB - IM MH - Humans MH - *Photography/methods MH - Reproducibility of Results MH - *Face/anatomy & histology MH - Female MH - *Anthropometry/methods MH - Male MH - Adolescent MH - Adult MH - Young Adult MH - Middle Aged MH - Observer Variation MH - Reference Values PMC - PMC13142683 COIS- Conflict of interests: nothing to declare. EDAT- 2026/04/22 18:32 MHDA- 2026/04/22 18:33 PMCR- 2026/03/31 CRDT- 2026/04/22 15:32 PHST- 2025/05/30 00:00 [received] PHST- 2025/09/07 00:00 [accepted] PHST- 2026/04/22 18:33 [medline] PHST- 2026/04/22 18:32 [pubmed] PHST- 2026/04/22 15:32 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - S2317-17822026000300606 [pii] AID - codas20250193_PT [pii] AID - 10.1590/2317-1782/e20250193pt [doi] PST - epublish SO - Codas. 2026 Apr 20;38(3):e20250193. doi: 10.1590/2317-1782/e20250193pt. eCollection 2026. PMID- 42013650 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260715 IS - 1878-5506 (Electronic) IS - 1389-9457 (Linking) VI - 144 DP - 2026 Aug TI - Distinct forms of childhood maltreatment and their associations with subjective and objective sleep during pregnancy. PG - 108951 LID - S1389-9457(26)00190-5 [pii] LID - 10.1016/j.sleep.2026.108951 [doi] AB - OBJECTIVES: To examine the associations between distinct forms of childhood maltreatment and subjective/objective sleep during the second trimester of pregnancy. METHODS: Seventy-two pregnant women (n = 42 with an history of childhood maltreatment) were assessed between 18 and 20 weeks of gestation, a period considered relatively stable within pregnancy. Sleep was evaluated using both subjective and objective measures. Subjective sleep was measured using two validated self-report questionnaires, the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale. Objective sleep was measured using actigraphy (Mini-Mitter/Respironics) worn on the non-dominant wrist for seven consecutive days, accompanied by daily sleep diaries. Linear regression models were used to test associations between five distinct forms of childhood maltreatment (physical neglect, emotional neglect, physical abuse, emotional abuse, and sexual abuse) and sleep parameters (subjective and objective measures). Analyses were conducted using both dichotomous exposure scores (yes/no based on validated cutoffs) and continuous severity scores. All models simultaneously controlled for other forms of childhood maltreatment types, maternal education and household income. RESULTS: Pregnant women with a history of childhood emotional abuse reported significantly poorer subjective sleep, reflected in a 2-point higher on the Pittsburgh Sleep Quality score (2.0 +/- .9, p = .03) compared to pregnant women without such histories. Objective actigraphy data indicated that pregnant women with a history of childhood sexual abuse obtained approximately 1 h less nighttime sleep (-62.1 +/- 20.3 min, p = .003) compared to pregnant women who did not report childhood sexual abuse. Analyses using continuous severity scores for each childhood maltreatment type yielded consistent findings. CONCLUSIONS: Distinct forms of childhood maltreatment appear to have different associations with subjective and objective sleep during pregnancy. These findings underscore the importance of replication in larger and more diverse samples, as well as the need for studies that monitor sleep across pregnancy to clarify mechanisms and inform trauma-informed approaches to perinatal sleep health. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Touchette, Evelyne AU - Touchette E AD - Department of Psychoeducation, Universite du Quebec a Trois-Rivieres, Quebec, Canada; Centre de recherche universitaire sur les jeunes et les familles, Quebec, Canada; Research Unit on Children's Psychosocial Maladjustment, Quebec, Canada; Centre d'etudes interdisciplinaires sur le developpement de l'enfant et la famille, Universite du Quebec a Trois-Rivieres, Quebec, Canada. Electronic address: Evelyne.Touchette@uqtr.ca. FAU - Zaine, Y-Lane Noemie AU - Zaine YN AD - Centre de recherche universitaire sur les jeunes et les familles, Quebec, Canada; Department of Psychoeducation, Universite de Sherbrooke, Quebec, Canada; Centre de recherche interdisciplinaire sur les problemes conjugaux et les agressions sexuelles, Quebec, Canada. FAU - Garon-Bissonnette, Julia AU - Garon-Bissonnette J AD - Peabody College of Education and Human Development, Vanderbilt University, Nashville, TN, USA. FAU - Lemieux, Roxanne AU - Lemieux R AD - Centre d'etudes interdisciplinaires sur le developpement de l'enfant et la famille, Universite du Quebec a Trois-Rivieres, Quebec, Canada; Centre de recherche interdisciplinaire sur les problemes conjugaux et les agressions sexuelles, Quebec, Canada; Department of Nursing Sciences, Universite du Quebec a Trois-Rivieres, Quebec, Canada. FAU - Berthelot, Nicolas AU - Berthelot N AD - Centre d'etudes interdisciplinaires sur le developpement de l'enfant et la famille, Universite du Quebec a Trois-Rivieres, Quebec, Canada; Centre de recherche interdisciplinaire sur les problemes conjugaux et les agressions sexuelles, Quebec, Canada; Department of Nursing Sciences, Universite du Quebec a Trois-Rivieres, Quebec, Canada. LA - eng PT - Journal Article DEP - 20260407 PL - Netherlands TA - Sleep Med JT - Sleep medicine JID - 100898759 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Adult MH - Actigraphy MH - *Sleep Quality MH - Surveys and Questionnaires MH - *Sleep/physiology MH - Self Report MH - Pregnancy Trimester, Second MH - Sleep Duration MH - *Adult Survivors of Child Abuse/psychology MH - *Sleep Wake Disorders MH - *Child Abuse/psychology MH - *Pregnancy Complications/psychology OTO - NOTNLM OT - Actigraphy OT - Epworth sleepiness scale OT - Pittsburgh sleep quality index OT - Sleep OT - Trauma and pregnancy COIS- Declaration of competing interest No conflict of interest has been declared by the authors. EDAT- 2026/04/22 00:35 MHDA- 2026/05/25 06:31 CRDT- 2026/04/21 18:06 PHST- 2025/09/17 00:00 [received] PHST- 2026/03/26 00:00 [revised] PHST- 2026/04/04 00:00 [accepted] PHST- 2026/05/25 06:31 [medline] PHST- 2026/04/22 00:35 [pubmed] PHST- 2026/04/21 18:06 [entrez] AID - S1389-9457(26)00190-5 [pii] AID - 10.1016/j.sleep.2026.108951 [doi] PST - ppublish SO - Sleep Med. 2026 Aug;144:108951. doi: 10.1016/j.sleep.2026.108951. Epub 2026 Apr 7. PMID- 42010697 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1745-6215 (Electronic) IS - 1745-6215 (Linking) VI - 27 IP - 1 DP - 2026 Apr 20 TI - EMERGE Mothers and Kids: a longitudinal cohort study of mothers and children enrolled in the randomized placebo-controlled trial of metformin in women with GDM (EMERGE): study protocol. LID - 10.1186/s13063-026-09703-6 [doi] LID - 405 AB - BACKGROUND: Pregnancies complicated by gestational diabetes mellitus (GDM) are associated with increased risks of adverse perinatal outcomes and with long-term metabolic and cardiovascular consequences for both mother and child. The original EMERGE randomized controlled trial (RCT) evaluated the effectiveness of early metformin in addition to usual care in women with GDM on glycemic control and perinatal outcomes. The primary objective of the EMERGE Mothers and Kids study is to evaluate long-term maternal cardiometabolic health and child anthropometric and neurodevelopmental outcomes following participation in the EMERGE trial. METHODS: This is a prospective, observational longitudinal cohort follow-up study of women and their children previously enrolled in the EMERGE trial (NCT06327191). Participants are invited to attend a follow-up visit in a single-site hospital-based clinical research setting at the Clinical Research Facility Galway, Ireland. Key inclusion criteria are women and their children who participated in the EMERGE trial and consent to follow-up. Key exclusion criteria include participants who did not provide consent for future follow-up studies. The planned follow-up sample is a pragmatic convenience sample of up to 321 mother-child pairs. A single follow-up visit will be conducted up to 6 years after the index pregnancy. Maternal assessments include anthropometric data, glucose tolerance, and metabolic parameters. Child assessments include growth metrics, adiposity measured via skinfold thickness, and neurodevelopmental status assessed through validated questionnaires. Additional data on quality of life, mental health, breastfeeding, and health economics will also be collected. DISCUSSION: This study aims to provide insights into the long-term safety and efficacy of metformin use during pregnancy, addressing the evidence gap in maternal cardiometabolic outcomes after metformin-treated GDM while also assessing child anthropometric and neurodevelopmental outcomes. TRIAL REGISTRATION: ClinicalTrials.gov NCT06327191. Registered on November 21, 2023. First planned enrollment in this follow-up study: July 2024. Trial record available at https://clinicaltrials.gov/study/NCT06327191 . CI - (c) 2026. The Author(s). FAU - Scairati, Roberta AU - Scairati R AD - HRB Clinical Research Facility Galway, University of Galway, Galway City, Co Galway, Ireland. AD - Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy. FAU - Newman, Christine AU - Newman C AD - HRB Clinical Research Facility Galway, University of Galway, Galway City, Co Galway, Ireland. cnewman@universityofgalway.ie. AD - College of Medicine Nursing and Health Sciences, University of Galway, Galway City, Co Galway, Ireland. cnewman@universityofgalway.ie. AD - Galway University Hospital, Newcastle Road, Galway City, Co Galway, Ireland. cnewman@universityofgalway.ie. AD - Institute for Clinical Trials, University of Galway, Galway City, Co Galway, Ireland. cnewman@universityofgalway.ie. AD - Clinical Trial Network Diabetes, University of Galway, Galway City, Co Galway, Ireland. cnewman@universityofgalway.ie. FAU - Alvarez-Iglesias, Alberto AU - Alvarez-Iglesias A AD - HRB Clinical Research Facility Galway, University of Galway, Galway City, Co Galway, Ireland. FAU - Smyth, Andrew AU - Smyth A AD - HRB Clinical Research Facility Galway, University of Galway, Galway City, Co Galway, Ireland. AD - College of Medicine Nursing and Health Sciences, University of Galway, Galway City, Co Galway, Ireland. AD - Galway University Hospital, Newcastle Road, Galway City, Co Galway, Ireland. FAU - O'Shea, Paula M AU - O'Shea PM AD - College of Medicine Nursing and Health Sciences, University of Galway, Galway City, Co Galway, Ireland. FAU - Devane, Declan AU - Devane D AD - HRB Clinical Research Facility Galway, University of Galway, Galway City, Co Galway, Ireland. AD - HRB Trials Methodology Research Network, University of Galway, Galway City, Co Galway, Ireland. FAU - Gillespie, Paddy AU - Gillespie P AD - School of Business and Economics, University of Galway, Galway City, Co Galway, Ireland. FAU - Egan, Aoife M AU - Egan AM AD - Mayo Clinic, Rochester, MN, USA. FAU - O'Donnell, Martin AU - O'Donnell M AD - HRB Clinical Research Facility Galway, University of Galway, Galway City, Co Galway, Ireland. AD - College of Medicine Nursing and Health Sciences, University of Galway, Galway City, Co Galway, Ireland. AD - Galway University Hospital, Newcastle Road, Galway City, Co Galway, Ireland. AD - Institute for Clinical Trials, University of Galway, Galway City, Co Galway, Ireland. FAU - Dunne, Fidelma P AU - Dunne FP AD - HRB Clinical Research Facility Galway, University of Galway, Galway City, Co Galway, Ireland. AD - College of Medicine Nursing and Health Sciences, University of Galway, Galway City, Co Galway, Ireland. AD - Galway University Hospital, Newcastle Road, Galway City, Co Galway, Ireland. AD - Institute for Clinical Trials, University of Galway, Galway City, Co Galway, Ireland. AD - Clinical Trial Network Diabetes, University of Galway, Galway City, Co Galway, Ireland. LA - eng SI - ClinicalTrials.gov/NCT06327191 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260420 PL - England TA - Trials JT - Trials JID - 101263253 RN - 9100L32L2N (Metformin) RN - 0 (Hypoglycemic Agents) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - Female MH - *Metformin/therapeutic use/adverse effects/administration & dosage MH - Pregnancy MH - *Diabetes, Gestational/drug therapy/blood/diagnosis MH - Longitudinal Studies MH - *Hypoglycemic Agents/therapeutic use/adverse effects/administration & dosage MH - Prospective Studies MH - Child Development MH - Randomized Controlled Trials as Topic MH - Adult MH - Child MH - Infant, Newborn MH - Blood Glucose/drug effects/metabolism MH - Observational Studies as Topic MH - Time Factors MH - Infant MH - Child, Preschool MH - Treatment Outcome PMC - PMC13224567 OTO - NOTNLM OT - Gestational diabetes mellitus OT - Long-term follow-up OT - Metformin OT - Pregnancy OT - Randomized controlled trial COIS- Declarations. Ethics approval and consent to participate: The study received ethical approval from the Galway Clinical Research Ethics Committee. Written informed consent was obtained at the time of original enrollment and reaffirmed at the follow-up visit (reference number CA 3024). Consent for publication: This manuscript does not contain any individual person's data in any form. Consent for publication is therefore not applicable. Results will be published in peer-reviewed journals and presented at international conferences. Competing interests: The authors declare no competing interests. The study received funding from Merck Healthcare KGaA, Darmstadt, Germany, which had no involvement in the design, analysis, or reporting of the study. EDAT- 2026/04/21 13:11 MHDA- 2026/06/01 00:32 PMCR- 2026/04/20 CRDT- 2026/04/21 00:19 PHST- 2025/09/23 00:00 [received] PHST- 2026/04/03 00:00 [accepted] PHST- 2026/06/01 00:32 [medline] PHST- 2026/04/21 13:11 [pubmed] PHST- 2026/04/21 00:19 [entrez] PHST- 2026/04/20 00:00 [pmc-release] AID - 10.1186/s13063-026-09703-6 [pii] AID - 9703 [pii] AID - 10.1186/s13063-026-09703-6 [doi] PST - epublish SO - Trials. 2026 Apr 20;27(1):405. doi: 10.1186/s13063-026-09703-6. PMID- 42009301 OWN - NLM STAT- MEDLINE DCOM- 20260622 LR - 20260622 IS - 1555-0273 (Electronic) IS - 1555-0265 (Linking) VI - 21 IP - 7 DP - 2026 Jul 1 TI - Can a Simple Trapezoidal Integration Approach Accurately Estimate the Supra-Critical Speed Distance Capacity of a Swimmer? PG - 831-836 LID - 10.1123/ijspp.2025-0372 [doi] AB - The 12 x 25-m swim test has become a key physiological monitoring and profiling tool within swimming networks to capture various performance insights (peak velocity, critical speed [CS], supra-CS distance capacity [D'], and anaerobic speed reserve) within one testing occasion. The D' output following the 12 x 25-m swim test is currently derived using software that requires specialised expertise, therefore inhibiting the accessibility of the test to pathways' level coaches and athletes. OBJECTIVES: The aim of the study was to determine if trapezoidal integration (TI) could simply and accurately replace the model fit method to estimate D' following the 12 x 25-m swim test and improve the accessibility of the test for a wider cohort of practitioners. METHODS: Thirty-one national-level swimmers preparing for the Paris 2024 Olympic Trials consented for their 12 x 25-m data set to be retrieved. D' was calculated using both the model fit and TI approaches. Linear regression and pearson correlations examined the strength of the relationship and a paired t test and Bland-Altman plot determined the agreement between the 2 methodologies. RESULTS: A very strong, positive relationship was found between the model fit and TI D' calculations (r = .999, R2 = .999, P < .001), with a very small, nonsignificant difference of 0.040 m (d = 0.124, P = .495). CONCLUSIONS: TI is a valid replacement for the original model fit approach to estimate D' following the 12 x 25-m swim test. The swim test will no longer require specialised software and the accessibility of the test will increase to a wider cohort of swimming practitioners. FAU - Bulte, Karla R AU - Bulte KR AUID- ORCID: 0009-0006-3363-2284 AD - Victorian Institute of Sport, Albert Park, VIC, Australia. AD - School of Exercise and Nutrition Sciences,Deakin University, Geelong, VIC, Australia. AD - Centre for Sport Research in the Institute for Physical Activity and Nutrition,Deakin University, Geelong, VIC, Australia. FAU - Mitchell, Lachlan L G AU - Mitchell LLG AUID- ORCID: 0000-0002-1621-8026 AD - Victorian Institute of Sport, Albert Park, VIC, Australia. FAU - Siegel, Rodney AU - Siegel R AUID- ORCID: 0009-0009-7277-8106 AD - School of Exercise and Nutrition Sciences,Deakin University, Geelong, VIC, Australia. FAU - Hunter, Adam AU - Hunter A AUID- ORCID: 0009-0007-4779-2593 AD - Australian Institute of Sport, Canberra, ACT, Australia. FAU - Brooks, Edward R AU - Brooks ER AUID- ORCID: 0000-0003-2649-9535 AD - Australian Institute of Sport, Canberra, ACT, Australia. FAU - Saunders, Philo U AU - Saunders PU AD - Australian Institute of Sport, Canberra, ACT, Australia. FAU - Hoffmann, Samantha M AU - Hoffmann SM AUID- ORCID: 0000-0001-8824-7531 AD - School of Exercise and Nutrition Sciences,Deakin University, Geelong, VIC, Australia. AD - Centre for Sport Research in the Institute for Physical Activity and Nutrition,Deakin University, Geelong, VIC, Australia. LA - eng PT - Journal Article DEP - 20260420 PL - United States TA - Int J Sports Physiol Perform JT - International journal of sports physiology and performance JID - 101276430 SB - IM MH - *Swimming/physiology MH - Humans MH - *Athletic Performance/physiology MH - Exercise Test MH - Area Under Curve MH - Models, Statistical MH - Male MH - Female MH - Adolescent MH - Young Adult OTO - NOTNLM OT - accessibility OT - anaerobic capacity OT - physiological profiling OT - physiological testing OT - validity EDAT- 2026/04/21 13:11 MHDA- 2026/06/16 18:34 CRDT- 2026/04/20 19:32 PHST- 2025/07/29 00:00 [received] PHST- 2025/12/15 00:00 [revised] PHST- 2026/02/09 00:00 [accepted] PHST- 2026/06/16 18:34 [medline] PHST- 2026/04/21 13:11 [pubmed] PHST- 2026/04/20 19:32 [entrez] AID - 10.1123/ijspp.2025-0372 [doi] PST - epublish SO - Int J Sports Physiol Perform. 2026 Apr 20;21(7):831-836. doi: 10.1123/ijspp.2025-0372. Print 2026 Jul 1. PMID- 42006403 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260420 LR - 20260813 IS - 2212-1366 (Print) IS - 2212-1374 (Electronic) IS - 2212-1366 (Linking) VI - 58 DP - 2026 Jun TI - Health-related quality of life and physical activity in children with Multiple Osteochondromas. PG - 100759 LID - 10.1016/j.jbo.2026.100759 [doi] LID - 100759 AB - OBJECTIVES: To evaluate health-related quality of life (HRQOL) and physical activity level (PAL) in children and adolescents with Multiple Osteochondromas (MO) and to identify factors associated with these outcomes. STUDY DESIGN: Cross-sectional survey of Dutch patients aged 4-18 years recruited through the national MO expertise center and the patient association. Validated, age-specific questionnaires assessed HRQOL (TAP/TAC/TAAQOL), PAL (Baecke), pain, functional disability, and psychosocial and sociodemographic variables. Multiple linear regression, guided by the International Classification of Functioning framework, examined associated variables with the mental and physical HRQOL components and with PAL. RESULTS: A total of 134 participants (53% male; mean age +/- SD, 11.4 +/- 3.7 years) completed the survey. Compared with population norms, patients with MO scored significantly lower on physical HRQOL but not consistently lower on mental HRQOL. Significant gender differences emerged in specific HRQOL domains across multiple age groups. Mean PAL was also reduced (7.35 +/- 1.01, p < 0.001) compared with healthy peers. Physical HRQOL (R(2) = 0.727, p < 0.001) was negatively associated with pain and positively with externalizing behavior. The mental HRQOL model (R(2) = 0.648, p < 0.001) showed the strongest negative associations with internalizing problems and functional disability. Having >/= 5 surgeries was the only independent predictor of PAL, explaining 4.4% of its variance. CONCLUSIONS: The pediatric MO population reports significantly lower physical HRQOL and PAL, but not consistently lower mental HRQOL than healthy peers. Specific gender differences were observed across multiple domains. The associations identified in this study call for a multidisciplinary approach to MO management that emphasizes pain control, functional rehabilitation, and psychosocial support. CI - (c) 2026 The Authors. Published by Elsevier GmbH. FAU - Amajjar, Ihsane AU - Amajjar I AD - Department of Rehabilitation Medicine, CAPHRI, Maastricht University, Maastricht, The Netherlands. AD - Department of Orthopaedic Surgery, OLVG, Amsterdam, The Netherlands. FAU - Willigenburg, Nienke W AU - Willigenburg NW AD - Department of Orthopaedic Surgery, OLVG, Amsterdam, The Netherlands. FAU - Langenberg, Benedikt G AU - Langenberg BG AD - Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands. FAU - Ham, S John AU - Ham SJ AD - Department of Orthopaedic Surgery, OLVG, Amsterdam, The Netherlands. FAU - Smeets, Rob J E M AU - Smeets RJEM AD - Department of Rehabilitation Medicine, CAPHRI, Maastricht University, Maastricht, The Netherlands. AD - Pain in Motion International Research Group, www.paininmotion.be, Brussels, Belgium. AD - Clinics in Revalidatie (CIR), Eindhoven, The Netherlands. LA - eng PT - Journal Article DEP - 20260402 PL - Netherlands TA - J Bone Oncol JT - Journal of bone oncology JID - 101610292 PMC - PMC13087577 OTO - NOTNLM OT - Exostoses OT - Multiple hereditary OT - Multiple osteochondromas OT - Physical activity OT - Primary bone tumours OT - Quality of life COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/20 13:10 MHDA- 2026/04/20 13:11 PMCR- 2026/04/02 CRDT- 2026/04/20 07:47 PHST- 2025/12/23 00:00 [received] PHST- 2026/03/30 00:00 [revised] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/04/20 13:11 [medline] PHST- 2026/04/20 13:10 [pubmed] PHST- 2026/04/20 07:47 [entrez] PHST- 2026/04/02 00:00 [pmc-release] AID - S2212-1374(26)00021-7 [pii] AID - 100759 [pii] AID - 10.1016/j.jbo.2026.100759 [doi] PST - epublish SO - J Bone Oncol. 2026 Apr 2;58:100759. doi: 10.1016/j.jbo.2026.100759. eCollection 2026 Jun. PMID- 42001045 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Apr 18 TI - Birth-size reference charts for newborns admitted to the neonatal intensive care units. LID - 10.1186/s12887-026-06889-1 [doi] LID - 509 AB - BACKGROUND: Our original birth-size reference charts (the Olsen charts), published in 2010 (weight, length, head circumference) and 2015 (body mass index), had limitations, including manually defined exclusion criteria and the use of completed gestational weeks. This project aimed to update the charts and address those limitations. METHODS: We analyzed de-identified data from infants admitted to Pediatrix NICUs between 2010 and 2022. In contrast to prior work, newborns with mortality before discharge, multiple births, and congenital anomalies were included; only statistical outliers (defined as two times the interquartile range below the first quartile or above the third quartile) were excluded. Gestational age was recorded in days, and penalized b-splines were used as curve smoothers. Birth weight, length, head circumference, and BMI models were developed using a randomly selected subset and validated by the remaining data. Proportions of SGA and LGA infants were compared to the 2010 Olsen and 2013 Fenton charts. RESULTS: One million one hundred fifty-two thousand seven hundred twenty infants born between 22 and 41 weeks of gestation were included. No overfitting bias was observed in the new charts. These charts more accurately identified the expected 10% of newborns as SGA/LGA compared to existing charts. CONCLUSIONS: The use of refined methods in new charts improved birth size referencing for NICU infants. FAU - Chou, Fu-Sheng AU - Chou FS AD - Southern California Permanente Medical Group, Pasadena, CA, USA. Fu-Sheng.X.Chou@kp.org. AD - Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA. Fu-Sheng.X.Chou@kp.org. AD - Department of Clinical Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA, USA. Fu-Sheng.X.Chou@kp.org. AD - Department of Neonatology, Kaiser Permanente Riverside Medical Center, 10800 Magnolia Ave., Riverside, CA, 92505, USA. Fu-Sheng.X.Chou@kp.org. FAU - Yeh, Hung-Wen AU - Yeh HW AD - Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO, USA. AD - Department of Pediatrics, School of Medicine, University of Missouri-Kansas City, Kansas City, MO, USA. FAU - Hsueh, Crystal AU - Hsueh C AD - Psychobiology Program, University of California, Los Angeles, CA, USA. FAU - Olsen, Irene E AU - Olsen IE AD - Department of Nutrition Sciences, College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA. FAU - Tolia, Veeral N AU - Tolia VN AD - Center for Research, Education, Quality and Safety, Pediatrix Inc., Sunrise, FL, USA. FAU - Clark, Reese H AU - Clark RH AD - Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA. LA - eng PT - Journal Article DEP - 20260418 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Infant, Newborn MH - *Intensive Care Units, Neonatal MH - *Birth Weight MH - Reference Values MH - Infant, Large for Gestational Age MH - *Growth Charts MH - Female MH - Gestational Age MH - Infant, Small for Gestational Age MH - Male MH - Body Mass Index PMC - PMC13224568 OTO - NOTNLM OT - Anthropometric measures OT - Growth charts OT - Neonatal intensive care units COIS- Declarations. Ethics approval and consent to participate: This data-only study with a deidentified dataset was deemed non-human research by the Kaiser Permanente Southern California Institutional Review Board ( https://kpscnursingresearch.org/kpsc-institutional-review-board-irb/ ). As such, informed consent to participate was not required, including from the parents or legal guardians of any participant under the age of 16. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/19 13:11 MHDA- 2026/06/28 06:36 PMCR- 2026/04/18 CRDT- 2026/04/18 23:24 PHST- 2025/10/30 00:00 [received] PHST- 2026/04/10 00:00 [accepted] PHST- 2026/06/28 06:36 [medline] PHST- 2026/04/19 13:11 [pubmed] PHST- 2026/04/18 23:24 [entrez] PHST- 2026/04/18 00:00 [pmc-release] AID - 10.1186/s12887-026-06889-1 [pii] AID - 6889 [pii] AID - 10.1186/s12887-026-06889-1 [doi] PST - epublish SO - BMC Pediatr. 2026 Apr 18;26(1):509. doi: 10.1186/s12887-026-06889-1. PMID- 42000095 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260613 IS - 1873-1597 (Electronic) IS - 1572-1000 (Linking) VI - 59 DP - 2026 Jun TI - Association between systemic inflammation and obesity-myopia comorbidity in adolescents: A cross-sectional analysis. PG - 105483 LID - S1572-1000(26)00150-X [pii] LID - 10.1016/j.pdpdt.2026.105483 [doi] AB - OBJECTIVE: This study aimed to investigate the association between systemic inflammation and the comorbidity of obesity and myopia among adolescents, focusing on the Systemic Immune-Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) as markers of inflammation. METHODS: This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning 1999-2008. The associations between SII and SIRI and obesity-myopia comorbidity were evaluated using multivariable logistic regression, restricted cubic spline (RCS) modeling, and subgroup analyses. RESULTS: A total of 8043 adolescents were included in this study. Multivariable logistic regression analysis indicated a significant positive association between both SII and SIRI, analyzed as continuous and quartile-based variables, and the likelihood of obesity-myopia comorbidity (p < 0.05). A dose-response relationship was observed, with the highest quartile of SII (Q4) associated with an odds ratio (OR) of 2.78 and the highest quartile of SIRI associated with an OR of 2.12. RCS analysis indicated significant nonlinear associations (SII: p(nonlinear) < 0.001; SIRI: p(nonlinear) = 0.001), suggesting that inflammation is positively associated with myopia after exceeding a critical threshold. Subgroup analysis demonstrated that these associations were statistically significant among adolescents with mild to moderate myopia, but not among those with high myopia. However, due to the non‑significant interaction term, these subgroup results should be considered exploratory analyses of this study. CONCLUSIONS: The findings of this study indicate a nonlinear dose-dependent association between systemic inflammatory markers (SII and SIRI) and the comorbidity of obesity and myopia in adolescents. This association was particularly evident in adolescents with mild to moderate myopia. However, due to the cross‑sectional design and the exploratory nature of the subgroup analyses, causality cannot be established, and further research is needed for validation. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Li, Minmin AU - Li M AD - The Second Clinical Medical College, Jinan University, Shenzhen, 518040 Guangdong Province, China. FAU - Deng, Hongwei AU - Deng H AD - Department of Strabismus and Pediatric Ophthalmology, Shenzhen Eye Hospital, Shenzhen Eye Center, Southern Medical University, Shenzhen, 518040 Guangdong Province, China. Electronic address: denghongwei@sz-eyes.com. FAU - Chen, Dingyan AU - Chen D AD - Shenzhen Center for Disease Control and Prevention, Shenzhen, 518055 Guangdong Province, China. FAU - Tao, Zhengyang AU - Tao Z AD - Department of Strabismus and Pediatric Ophthalmology, Shenzhen Eye Hospital, Shenzhen Eye Center, Southern Medical University, Shenzhen, 518040 Guangdong Province, China. FAU - Xu, Zhixing AU - Xu Z AD - The Second Clinical Medical College, Jinan University, Shenzhen, 518040 Guangdong Province, China. FAU - Hu, Guorui AU - Hu G AD - The Second Clinical Medical College, Jinan University, Shenzhen, 518040 Guangdong Province, China. FAU - Lv, Zongyue AU - Lv Z AD - Department of Strabismus and Pediatric Ophthalmology, Shenzhen Eye Hospital, Shenzhen Eye Center, Southern Medical University, Shenzhen, 518040 Guangdong Province, China. LA - eng PT - Journal Article DEP - 20260416 PL - Netherlands TA - Photodiagnosis Photodyn Ther JT - Photodiagnosis and photodynamic therapy JID - 101226123 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Adolescent MH - Male MH - *Inflammation/epidemiology MH - Comorbidity MH - *Myopia/epidemiology/immunology MH - *Obesity/epidemiology MH - Nutrition Surveys OTO - NOTNLM OT - Cross-sectional study OT - Inflammation OT - Myopia OT - Nonlinear association OT - Obesity OT - Obesity-myopia comorbidity OT - Systemic Immune-inflammation Index (SII), Systemic inflammatory response index (SIRI) COIS- Declaration of competing interest The authors declare that they have no competing interests. EDAT- 2026/04/19 13:11 MHDA- 2026/06/15 11:32 CRDT- 2026/04/18 19:16 PHST- 2026/03/02 00:00 [received] PHST- 2026/04/10 00:00 [revised] PHST- 2026/04/15 00:00 [accepted] PHST- 2026/06/15 11:32 [medline] PHST- 2026/04/19 13:11 [pubmed] PHST- 2026/04/18 19:16 [entrez] AID - S1572-1000(26)00150-X [pii] AID - 10.1016/j.pdpdt.2026.105483 [doi] PST - ppublish SO - Photodiagnosis Photodyn Ther. 2026 Jun;59:105483. doi: 10.1016/j.pdpdt.2026.105483. Epub 2026 Apr 16. PMID- 41999989 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260803 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 224 DP - 2026 Sep 1 TI - Evaluation of parental reports as a proxy for their children's food preferences. PG - 108561 LID - S0195-6663(26)00123-6 [pii] LID - 10.1016/j.appet.2026.108561 [doi] AB - As childhood obesity rates rise, research on children's food preferences gains importance. However, studies on these preferences have predominantly relied on parental reports. Research assumes that parents are accurate informants, given their role as food providers. However, excluding children introduces limitations, as parents may misinterpret or overestimate their children's food preferences. Conversely, children's self-reports are hampered by cognitive and language challenges. Leveraging an online survey, this study examines whether children's reports of their food preferences align with those reported by their parents. A diverse range of statistical methods was implemented to examine agreement in 510 parent-child dyads. These included Spearman's rho, intra-class correlation coefficients, Multitrait-Multimethod analysis complemented with a confirmatory factor analysis (MTMM-CFA), and linear regressions. There were strong correlations across food-related constructs, indicating robust consensus (r >/= 0.60). MTMM-CFA model comparison analyses also demonstrated strong convergent (r >/= 0.61) and discriminant validity (r emotion regulation ability --> positive coping strategies; (2) body image satisfaction --> cultural adaptation level --> social support level. In addition, a significant relationship exists between mental health and study abroad satisfaction. Moderation analysis indicates that digital social media use is related to the positive association between physical activity and mental health. CONCLUSIONS: Physical activity is positively associated with the mental health of Chinese international students and is related to higher study abroad satisfaction through dual psychosocial pathways. The use of digital social media appears to play a positive moderating role in this process, suggesting that cross-cultural interventions may achieve better outcomes by combining physical activity with appropriate digital support strategies. CI - (c) 2026. The Author(s). FAU - Liu, Zhaoyu AU - Liu Z AD - Department of Sport & Healthcare, Namseoul University, Cheonan, 31020, Korea. zhaoyuliu618@gmail.com. FAU - Quan, Qingyun AU - Quan Q AD - Sports Medicine Laboratory, Korea National Sport University, Seoul, 05541, Korea. FAU - Long, Biao AU - Long B AD - Department of Sport & Healthcare, Namseoul University, Cheonan, 31020, Korea. FAU - Kim, Soohyun AU - Kim S AD - Department of Sport & Healthcare, Namseoul University, Cheonan, 31020, Korea. shkim001@nsu.ac.kr. LA - eng SI - figshare/figshare.30074896 PT - Journal Article DEP - 20260415 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - Chinese people SB - IM MH - Humans MH - *Psychological Well-Being MH - *Personal Satisfaction MH - Female MH - *Exercise/psychology MH - *Students/psychology/statistics & numerical data MH - Cross-Sectional Studies MH - China MH - Male MH - Young Adult MH - *Cross-Cultural Comparison MH - Adolescent MH - Adult MH - Surveys and Questionnaires MH - Social Media/statistics & numerical data MH - *Mental Health MH - East Asian People PMC - PMC13200439 OTO - NOTNLM OT - Chain mediation OT - Chinese international students OT - Digital social media use OT - Physical activity OT - Psychological wellbeing OT - Study abroad satisfaction COIS- Declarations. Ethics approval and consent to participate: All procedures in this study adhered to the ethical standards of the 1964 Declaration of Helsinki and its later amendments. The study was reviewed by the Institutional Review Board of Namseoul University and was granted exemption from full ethical approval, in accordance with national regulations. Informed consent was obtained from all participants. The questionnaire used in this study was adapted from previously validated instruments rather than newly developed. An English version of the adapted items has been uploaded as Supplementary Material S1. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/16 13:09 MHDA- 2026/05/25 06:31 PMCR- 2026/04/15 CRDT- 2026/04/16 01:09 PHST- 2025/09/10 00:00 [received] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/05/25 06:31 [medline] PHST- 2026/04/16 13:09 [pubmed] PHST- 2026/04/16 01:09 [entrez] PHST- 2026/04/15 00:00 [pmc-release] AID - 10.1186/s12889-026-27280-w [pii] AID - 27280 [pii] AID - 10.1186/s12889-026-27280-w [doi] PST - epublish SO - BMC Public Health. 2026 Apr 15;26(1):1689. doi: 10.1186/s12889-026-27280-w. PMID- 41986943 OWN - NLM STAT- MEDLINE DCOM- 20261021 LR - 20261021 IS - 2154-4700 (Electronic) IS - 1933-8244 (Linking) VI - 81 IP - 5-6 DP - 2026 TI - Associations between ultra-processed food consumption, work-related and mental health outcomes among staff at a private hospital in Turkiye. PG - 113-125 LID - 10.1080/19338244.2026.2654391 [doi] AB - This study explored the relationship between ultra-processed food (UPF) consumption and work performance, sleep quality, and mental well-being among hospital staff in Turkiye using a cross-sectional design. A total of 150 participants aged 18-65 were included. Data were collected using validated instruments: the Pittsburgh Sleep Quality Index (PSQI), the Warwick-Edinburgh Mental Well-Being Scale (WEMWBS), and the Job Performance Scale (JPS). Participants were divided into three groups based on their daily UPF consumption: low (<306.97 g/day), moderate (306.97-778.57 g/day), and high (>778.57 g/day). The mean UPF intake was 507.3 +/- 288.1 g/day. Overall, 51.3% of participants had poor sleep quality. Mean PSQI scores were 5.05 +/- 2.12 in the low UPF group and 5.48 +/- 3.21 in the high group (p = 0.360). Participants in the high UPF group had a mean WEMWBS score of 60.04 +/- 9.45, compared to 56.10 +/- 7.02 in the low UPF group (p = 0.019). The high UPF group showed higher job performance scores (mean = 50.44 +/- 4.93) compared to the moderate group (mean = 46.23 +/- 7.27) and the low group (mean = 46.07 +/- 7.25) (p = 0.016). While the findings suggest a positive association between UPF consumption and both mental well-being and job performance, these results should be interpreted with caution due to the cross-sectional nature of the study. Further research is needed to explore long-term effects and underlying mechanisms. Additionally, future research could examine whether short-term improvements in mood or energy from UPF consumption translate into long-term health tradeoffs. FAU - Yenice Kartal, Esma AU - Yenice Kartal E AUID- ORCID: 0009-0006-5026-3011 AD - Institute of Health Science, Department of Nutrition and Dietetics, Uskudar University, Istanbul, Turkiye. FAU - Yilmaz, Haci Omer AU - Yilmaz HO AUID- ORCID: 0000-0003-4597-7758 AD - Faculty of Health Science, Department of Nutrition and Dietetics, Bandirma Onyedi Eylul University, Balikesir, Turkiye. LA - eng PT - Journal Article DEP - 20260415 PL - United States TA - Arch Environ Occup Health JT - Archives of environmental & occupational health JID - 101282564 SB - IM MH - *Fast Foods/statistics & numerical data MH - *Mental Health/statistics & numerical data MH - *Personnel, Hospital/psychology/statistics & numerical data MH - Psychological Well-Being MH - Hospitals, Private/statistics & numerical data MH - Sleep Quality MH - *Work Performance/statistics & numerical data MH - *Feeding Behavior MH - Cross-Sectional Studies MH - Turkey MH - Surveys and Questionnaires/statistics & numerical data MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged OTO - NOTNLM OT - Hospital staff OT - Ultra-processed foods OT - job performance OT - mental health OT - sleep quality EDAT- 2026/04/16 13:09 MHDA- 2026/05/31 18:32 CRDT- 2026/04/16 00:13 PHST- 2026/05/31 18:32 [medline] PHST- 2026/04/16 13:09 [pubmed] PHST- 2026/04/16 00:13 [entrez] AID - 10.1080/19338244.2026.2654391 [doi] PST - ppublish SO - Arch Environ Occup Health. 2026;81(5-6):113-125. doi: 10.1080/19338244.2026.2654391. Epub 2026 Apr 15. PMID- 41984914 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 4 DP - 2026 TI - Validating self-reported exclusive breastfeeding in Eswatini using stable isotope techniques. PG - e0346799 LID - 10.1371/journal.pone.0346799 [doi] LID - e0346799 AB - Exclusive breastfeeding (EBF) prevalence at the population level is typically assessed through maternal or caregiver reports, which are prone to recall and social desirability biases. The deuterium oxide dose-to-mother (DTM) technique offers an objective alternative by administering a small amount of deuterium-labeled water to lactating mothers. This study compared the prevalence of EBF from maternal recall versus the DTM method in Eswatini and evaluated the strengths and limitations of both approaches in assessing infant feeding practices linked to malnutrition. A total of 102 mother-infant pairs were recruited from three regional hospitals and three health centers in Eswatini. EBF was assessed by maternal recall using the WHO 24-hour infant feeding recall method and objectively measured using the DTM stable isotope technique at three infant age intervals: 6 weeks to 2.4 months (n = 26), 2.5 to 4.0 months (n = 43), and 4.1 to 5.5 months (n = 33). Two cutoff values defined EBF status via the stable isotope method. Agreement between maternal recall and DTM measurements was analyzed using Kappa statistics. Maternal recall consistently overestimated EBF across all time points compared to the DTM method. Using Model 1 cutoffs, prevalences of EBF by maternal recall vs. DTM were 100% vs. 50% ( moderate > mild) incurred 2.4 point increases in total HJHS. Pain was present in 76% of joints with individual joint scores >10. CONCLUSION: This study quantifies current differences in total HJHS relative to haemophilia type, severity, age and treatment in males. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Warren, Beth Boulden AU - Warren BB AD - University of Colorado Hemophilia and, Thrombosis Center, Aurora, Colorado, USA. FAU - Thornhill, Dianne AU - Thornhill D AD - University of Colorado Hemophilia and, Thrombosis Center, Aurora, Colorado, USA. FAU - Singer-Fox, Laura AU - Singer-Fox L AD - University of Colorado Hemophilia and, Thrombosis Center, Aurora, Colorado, USA. FAU - Smith, Julie AU - Smith J AD - University of Colorado Hemophilia and, Thrombosis Center, Aurora, Colorado, USA. FAU - Funk, Sharon AU - Funk S AD - University of Colorado Hemophilia and, Thrombosis Center, Aurora, Colorado, USA. FAU - Manco-Johnson, Marilyn AU - Manco-Johnson M AD - University of Colorado Hemophilia and, Thrombosis Center, Aurora, Colorado, USA. LA - eng GR - K23 HL151886/HL/NHLBI NIH HHS/United States GR - 2H30MC24049/Maternal Child Health Bureau and the Health Resources and Services Administration (HRSA) of the US Department of Health and Human Services (HHS)/ GR - Mountain States Hemophilia Network/ PT - Journal Article DEP - 20260414 PL - England TA - Haemophilia JT - Haemophilia : the official journal of the World Federation of Hemophilia JID - 9442916 SB - IM MH - Humans MH - Male MH - *Hemophilia A/pathology/complications MH - Cross-Sectional Studies MH - Female MH - Severity of Illness Index MH - Adult MH - Adolescent MH - Child MH - Young Adult MH - Middle Aged MH - *Joints/pathology MH - Child, Preschool MH - Aged MH - *Hemophilia B MH - Infant PMC - PMC13318164 MID - NIHMS2174160 OTO - NOTNLM OT - Haemophilia A OT - Haemophilia B OT - haemarthrosis OT - joints OT - prophylaxis COIS- Beth Boulden Warren reports a relationship with Takeda Pharmaceuticals USA Inc and Sanofi that include consulting or advisory. Marilyn Manco-Johnson reports relationships with Genentech Inc and Roche that include consulting or advisory. Dianne Thornhill, Laura Singer-Fox, Julie Smith and Sharon Funk declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/14 12:35 MHDA- 2026/07/17 12:41 PMCR- 2026/07/17 CRDT- 2026/04/14 06:13 PHST- 2026/03/10 00:00 [revised] PHST- 2025/09/27 00:00 [received] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/07/17 12:41 [medline] PHST- 2026/04/14 12:35 [pubmed] PHST- 2026/04/14 06:13 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - HAE70283 [pii] AID - 10.1111/hae.70283 [doi] PST - ppublish SO - Haemophilia. 2026 Jul-Aug;32(4):1016-1024. doi: 10.1111/hae.70283. Epub 2026 Apr 14. PMID- 41978199 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 7 DP - 2026 Apr 3 TI - Sustainable Eating in Saudi Arabia: Associations Between Food Sustainability Knowledge, Attitudes, Food Waste-Related Behaviours, and Dietary Choices Among Adults. LID - 10.3390/nu18071149 [doi] LID - 1149 AB - Background/Objectives: Sustainable food habits are essential for reducing the environmental impacts of a food system. We investigated food sustainability knowledge, attitudes, and food waste-related behaviours among Saudi adults and assessed their associations with socio-demographic characteristics and dietary choices, which are subjects that remain under-researched. Methods: A cross-sectional study was conducted among 855 Saudi adults (>/=18 years) using convenience sampling. Data were collected using a validated online questionnaire assessing sustainability knowledge, attitudes, food waste behaviours, dietary choices, and socio-demographic characteristics. Descriptive statistics, chi-square tests, and linear regression analyses were performed using SPSS version 29. Results: Overall, 32% of the study population demonstrated adequate sustainability knowledge, 61% expressed positive attitudes towards food sustainability, and 45% demonstrated favourable food waste management. Women were more knowledgeable than men. Participants who possessed a better understanding of food sustainability consumed more vegetables, fruits, and bread and less processed meat. Those with a positive attitude towards food sustainability exhibited higher consumption of red meat, white meat, eggs, milk, yogurt, cheese, vegetables, fruits, bread, and sweet or savoury snacks. Meanwhile, individuals with better food waste behaviours demonstrated significantly lower consumption of legumes, fish, pasta, red meat, white meat, processed meat, eggs, milk, yogurt, cheese, fruits, bread, and sweet or savoury snacks. Conclusions: Saudi adults possess limited knowledge of sustainability and suboptimal food waste behaviours despite having relatively positive attitudes. These findings highlight opportunities for intervention. Public education, targeted campaigns, and media communication could enhance sustainability awareness and promote healthier, environmentally sustainable dietary patterns. FAU - Alghamdi, Areej A AU - Alghamdi AA AUID- ORCID: 0009-0003-4269-1719 AD - Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah 22254, Saudi Arabia. FAU - Aljefree, Najlaa M AU - Aljefree NM AUID- ORCID: 0000-0001-9598-7140 AD - Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah 22254, Saudi Arabia. FAU - Shatwan, Israa M AU - Shatwan IM AUID- ORCID: 0000-0003-0222-9135 AD - Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah 22254, Saudi Arabia. FAU - Almoraie, Noha M AU - Almoraie NM AUID- ORCID: 0000-0002-2212-1255 AD - Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah 22254, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260403 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Food Loss and Waste) SB - IM MH - Humans MH - Saudi Arabia MH - Male MH - Female MH - *Health Knowledge, Attitudes, Practice MH - Adult MH - Cross-Sectional Studies MH - Food Loss and Waste MH - Middle Aged MH - *Feeding Behavior MH - Young Adult MH - *Diet MH - *Food Preferences MH - Adolescent MH - Surveys and Questionnaires MH - *Choice Behavior PMC - PMC13075233 OTO - NOTNLM OT - attitude OT - behaviour OT - dietary choices OT - knowledge OT - sustainable food habits COIS- The authors declare no conflicts of interest. EDAT- 2026/04/14 06:31 MHDA- 2026/04/14 06:32 PMCR- 2026/04/03 CRDT- 2026/04/14 01:11 PHST- 2026/01/31 00:00 [received] PHST- 2026/03/24 00:00 [revised] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/04/14 06:32 [medline] PHST- 2026/04/14 06:31 [pubmed] PHST- 2026/04/14 01:11 [entrez] PHST- 2026/04/03 00:00 [pmc-release] AID - nu18071149 [pii] AID - nutrients-18-01149 [pii] AID - 10.3390/nu18071149 [doi] PST - epublish SO - Nutrients. 2026 Apr 3;18(7):1149. doi: 10.3390/nu18071149. PMID- 41978182 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 7 DP - 2026 Mar 31 TI - Measuring the Ecological Footprint of Eating Behaviors: A Psychometric Study on the Turkish Version of the EREC Scale. LID - 10.3390/nu18071132 [doi] LID - 1132 AB - BACKGROUND/OBJECTIVES: This study was conducted to determine the validity and reliability of the Eating-Related Eco-Concern (EREC) in young Turkish adults and to evaluate the effect of ecological concerns on disordered eating characteristics, with a view to comparing these effects with the risk of eating disorders. METHODS: The study included 600 young adults (138 males and 462 females) aged 18 to 35. Using face-to-face administration, the Eating Disorder Examination Questionnaire (EDE-Q-13) Short Form to assess eating disorder-related psychopathology and the EREC Scale to assess eating behaviors related to eco-concern were administered, and Turkish validity and reliability were examined. RESULTS: The Kaiser-Meyer-Olkin (KMO) was 0.801, signifying acceptable sample adequacy, while Bartlett's test of sphericity was significant (chi(2) = 636.159, p < 0.001). All item factor loadings ranged from 0.582 to 0.767 and were statistically significant (p < 0.001). The scale's Cronbach's alpha was 0.854. Test-retest reliability was good, with an infraclass correlation coefficient (ICC) of 0.811 95% CI. The analysis revealed that the single-factor model demonstrated an acceptable fit to the data (chi(2)/df = 2.84, CFI = 0.976). There was no statistically significant correlation between EREC and the total EDE-Q-13 score (p = 0.064). On the other hand, the total EDE-Q-13 score was identified as a significant negative predictor of EREC scores (beta = -2.648, p = 0.028). CONCLUSIONS: All item factors of the Turkish adaptation of the scale exhibit a structure that is quite consistent with the original scale. The 10-question version of EREC can be used with young adults in Turkiye. In this study, although ecological anxiety was associated with eating restraint or purging, it was not found to be generally associated with eating disorders. FAU - Ayhan, Busra AU - Ayhan B AUID- ORCID: 0000-0001-8617-8552 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara 06490, Turkiye. FAU - Govez, Nazlican Erdogan AU - Govez NE AUID- ORCID: 0000-0003-2969-4109 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara 06490, Turkiye. FAU - Bilici, Saniye AU - Bilici S AUID- ORCID: 0000-0002-1235-0329 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara 06490, Turkiye. FAU - Koksal, Eda AU - Koksal E AUID- ORCID: 0000-0002-7930-9910 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara 06490, Turkiye. FAU - Tekin, Nasminel AU - Tekin N AUID- ORCID: 0009-0001-4163-1867 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara 06490, Turkiye. LA - eng PT - Journal Article PT - Validation Study DEP - 20260331 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Turkey MH - Female MH - *Psychometrics MH - Reproducibility of Results MH - *Feeding Behavior/psychology MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Male MH - Young Adult MH - Adult MH - Surveys and Questionnaires MH - Adolescent PMC - PMC13074659 OTO - NOTNLM OT - EDE-Q-13 OT - EREC OT - eating behavior OT - eco-concern OT - validation COIS- The authors declare no conflicts of interest. EDAT- 2026/04/14 06:31 MHDA- 2026/04/14 06:32 PMCR- 2026/03/31 CRDT- 2026/04/14 01:11 PHST- 2026/02/19 00:00 [received] PHST- 2026/03/24 00:00 [revised] PHST- 2026/03/26 00:00 [accepted] PHST- 2026/04/14 06:32 [medline] PHST- 2026/04/14 06:31 [pubmed] PHST- 2026/04/14 01:11 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - nu18071132 [pii] AID - nutrients-18-01132 [pii] AID - 10.3390/nu18071132 [doi] PST - epublish SO - Nutrients. 2026 Mar 31;18(7):1132. doi: 10.3390/nu18071132. PMID- 41978179 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 7 DP - 2026 Mar 31 TI - Association Between Mineral Intake and Cognitive Performance in Spanish Adults with Overweight and Obesity: A Cross-Sectional Study. LID - 10.3390/nu18071129 [doi] LID - 1129 AB - Background/Objectives: While adequate mineral intake is essential for brain health and cognitive function across the lifespan, the potential impact of excessive consumption remains underexplored. This study aimed to examine the association between dietary intake of selected minerals, with particular focus on iron and zinc, and cognitive performance in Spanish adults with obesity, particularly in executive-related domains such as reasoning, cognitive flexibility, and working memory. Methods: A cross-sectional study was conducted in 230 Spanish adults (18-65 years) from the Tech4Diet-Person project. Sociodemographic, dietary, and cognitive data were collected between 2021 and 2024. Cognitive function was assessed using the validated computerized CogniFit battery, and mineral intake was estimated through a food frequency questionnaire (93 items). Individuals with neurological, metabolic, or psychiatric disorders, as well as pregnant or lactating women, were excluded. Results: Participants had a mean age of 45.91 (+/-9.92) years. Nominal differences in mineral intake were observed across specific executive cognitive domains. Higher dietary iron intake was associated with lower performance in reasoning and cognitive flexibility, while higher zinc intake was associated with lower working memory performance. In adjusted logistic regression models, higher iron intake was independently associated with increased odds of low reasoning performance (OR = 1.25; p = 0.006), and higher zinc intake was associated with increased odds of low working memory performance (OR = 1.36; p = 0.024), after controlling for age, educational level, BMI, and total energy intake. Conclusions: Higher self-reported intake of iron and zinc showed nominal associations with lower performance in specific executive domains. These findings should be considered exploratory and require confirmation in longitudinal and biomarker-based studies. FAU - Tome-Fernandez, Mario AU - Tome-Fernandez M AUID- ORCID: 0009-0009-1471-8260 AD - Department of Health Psychology, Faculty of Health Science, University of Alicante, 03690 Alicante, Spain. FAU - Martin-Manchado, Laura AU - Martin-Manchado L AUID- ORCID: 0009-0009-4889-4967 AD - Department of Nursing, Faculty of Health Science, University of Alicante, 03690 Alicante, Spain. FAU - Sanchez-Sansegundo, Miriam AU - Sanchez-Sansegundo M AUID- ORCID: 0000-0003-2114-6503 AD - Department of Health Psychology, Faculty of Health Science, University of Alicante, 03690 Alicante, Spain. AD - Alicante Health and Biomedical Research Institute, ISABIAL Foundation, 03010 Alicante, Spain. FAU - Zaragoza-Marti, Ana AU - Zaragoza-Marti A AUID- ORCID: 0000-0001-8865-2326 AD - Department of Nursing, Faculty of Health Science, University of Alicante, 03690 Alicante, Spain. AD - Alicante Health and Biomedical Research Institute, ISABIAL Foundation, 03010 Alicante, Spain. FAU - Azorin-Lopez, Jorge AU - Azorin-Lopez J AUID- ORCID: 0000-0003-4762-6927 AD - Department of Computer Science and Technology, University of Alicante, 03690 Alicante, Spain. FAU - Hurtado-Sanchez, Jose Antonio AU - Hurtado-Sanchez JA AUID- ORCID: 0000-0002-6363-2385 AD - Department of Health Psychology, Faculty of Health Science, University of Alicante, 03690 Alicante, Spain. AD - Alicante Health and Biomedical Research Institute, ISABIAL Foundation, 03010 Alicante, Spain. LA - eng GR - PID2023-149562OB-I00/Ministry of Science, Innovation and Universities/ PT - Journal Article DEP - 20260331 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - J41CSQ7QDS (Zinc) RN - 0 (Minerals) SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Middle Aged MH - Adult MH - Male MH - Spain MH - *Cognition MH - *Obesity/psychology MH - *Overweight/psychology MH - Young Adult MH - Adolescent MH - Zinc/administration & dosage MH - Executive Function MH - Cognitive Flexibility MH - Aged MH - Memory, Short-Term MH - *Diet MH - *Minerals/administration & dosage PMC - PMC13075055 OTO - NOTNLM OT - cognitive performance OT - executive function OT - iron OT - micronutrients OT - mineral intake OT - nutrition OT - zinc COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/04/14 06:32 MHDA- 2026/04/14 06:33 PMCR- 2026/03/31 CRDT- 2026/04/14 01:11 PHST- 2026/02/20 00:00 [received] PHST- 2026/03/26 00:00 [revised] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/04/14 06:33 [medline] PHST- 2026/04/14 06:32 [pubmed] PHST- 2026/04/14 01:11 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - nu18071129 [pii] AID - nutrients-18-01129 [pii] AID - 10.3390/nu18071129 [doi] PST - epublish SO - Nutrients. 2026 Mar 31;18(7):1129. doi: 10.3390/nu18071129. PMID- 41978166 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260818 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 7 DP - 2026 Mar 31 TI - Lifetime Soy Intake and Adult Mammographic Density in Chinese Premenopausal Women. LID - 10.3390/nu18071116 [doi] LID - 1116 AB - Background: Soy intake has been proposed as a protective factor for breast cancer, especially when exposure occurs early in life. Mammographic density (MD) is a strong predictor of breast cancer risk, but evidence linking soy intake at specific life stages to adult mammographic density remains limited. Objective: The objective of this study was to evaluate the associations between dietary soy intake at different life stages and MD in premenopausal Chinese women. Methods: Dietary soy intake was assessed using a validated soy food frequency questionnaire for the past 12 months and retrospectively for earlier life stages (childhood: 6-12 years; adolescence: 13-18 years; young adulthood: 20-34 years), with recall aided by a life history calendar. MD was measured from bilateral cranio-caudal mammograms using a standardized computer-assisted method. Multivariable regression models were used to evaluate associations between soy protein and isoflavone intake at different life stages and MD, adjusting for relevant confounders. Results: Among 815 premenopausal women (mean age 40.9 y), mean current soy protein and isoflavone intakes were 10.3 g/day and 22.0 mg/day, respectively. Soy intakes across life stages were moderately correlated (r = 0.33-0.81). After multivariable adjustment, soy protein intake during adolescence (beta = -0.067, SE = 0.029, p = 0.023) and childhood (beta = -0.071, SE = 0.032, p = 0.028) was significantly and inversely associated with adult MD. Young adult intake showed a non-significant inverse trend (beta = -0.052, p = 0.075), and current intake showed no association (p = 0.93). Higher mean early-life (ages 6-18) and life course soy intakes were also inversely associated with MD (beta range: -0.077 to -0.082; all p < 0.05). Women with consistently high early-life soy intake had 5.8-6.6% lower adjusted MD than those with consistently low intake. Conclusions: Early-life soy exposure may influence adult breast tissue composition and represents a potentially modifiable protective factor in breast cancer prevention. These findings carry important public health implications, particularly for populations experiencing dietary westernization. FAU - Ho, Suzanne C AU - Ho SC AUID- ORCID: 0000-0001-5232-2886 AD - JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China. FAU - Boyd, Norman F AU - Boyd NF AD - Princess Margaret Cancer Centre and Imaging Research, University of Toronto, Toronto, ON M5S 3G8, Canada. FAU - Tam, Wilson W S AU - Tam WWS AUID- ORCID: 0000-0003-0641-3060 AD - Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore. FAU - Yeo, Winnie AU - Yeo W AUID- ORCID: 0000-0002-0863-8469 AD - Department of Clinical Oncology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China. FAU - Chu, Winnie C W AU - Chu WCW AUID- ORCID: 0000-0003-4962-4132 AD - Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China. FAU - So, Edwina K F AU - So EKF AD - JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China. FAU - Yu, Ruby AU - Yu R AUID- ORCID: 0000-0001-7051-4689 AD - JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China. FAU - Woo, Jean AU - Woo J AUID- ORCID: 0000-0001-7593-3081 AD - Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China. LA - eng GR - 2003/81/World Cancer Research Fund International/ PT - Journal Article DEP - 20260331 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Soybean Proteins) RN - 0 (Isoflavones) RN - Chinese people SB - IM MH - Humans MH - Female MH - Adult MH - *Premenopause MH - *Breast Density MH - Adolescent MH - China MH - Young Adult MH - *Soybean Proteins/administration & dosage MH - *Soy Foods MH - *Breast Neoplasms/prevention & control MH - Retrospective Studies MH - Child MH - Mammography MH - *Diet MH - Isoflavones/administration & dosage MH - Risk Factors MH - Middle Aged MH - East Asian People PMC - PMC13074378 OTO - NOTNLM OT - Chinese premenopausal women OT - life course exposure OT - mammographic density OT - soy protein COIS- The authors declare no conflicts of interest. EDAT- 2026/04/14 06:32 MHDA- 2026/04/14 06:33 PMCR- 2026/03/31 CRDT- 2026/04/14 01:11 PHST- 2026/03/02 00:00 [received] PHST- 2026/03/19 00:00 [revised] PHST- 2026/03/28 00:00 [accepted] PHST- 2026/04/14 06:33 [medline] PHST- 2026/04/14 06:32 [pubmed] PHST- 2026/04/14 01:11 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - nu18071116 [pii] AID - nutrients-18-01116 [pii] AID - 10.3390/nu18071116 [doi] PST - epublish SO - Nutrients. 2026 Mar 31;18(7):1116. doi: 10.3390/nu18071116. PMID- 41978161 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 7 DP - 2026 Mar 30 TI - Establish Global Nutrition Research Strategies: The Meeting Report of the First SIOP Nutrition Research Forum. LID - 10.3390/nu18071112 [doi] LID - 1112 AB - Despite strong evidence linking nutritional status to treatment efficacy and survival in pediatric cancer, significant knowledge gaps and practice variation persist globally. On 24th October 2025, the International Society of Paediatric Oncology (SIOP) Nutrition Network, in collaboration with Prinsess Maxima Center for Paediatric Oncology and the International Initiative for Pediatrics and Nutrition (IIPAN), convened the first global SIOP Nutrition Network Research Forum. The forum brought together 54 international experts from high-income countries and low- and middle-income countries to define global nutrition research strategies for pediatric oncology. The forum addressed six emerging domains: body composition and treatment outcomes; microbiome, micronutrient status and metabolic health; prehabilitation and rehabilitation strategies; validation of nutritional assessment tools, guideline development for high-income settings; insights from international multicentric research initiatives-the International Atomic Energy Agency (IAEA), SIOP Nutrition Network, the Adapted Resource and Implementation Application (ARIA) guide nutrition portal, the International Collaboration on Nutrition in Cancer (ICONIC) WHO knowledge portal; and IIPAN and the World Cancer Research Fund (WCRF) for funding strategies. Delegates identified three priority working groups, namely prehabilitation optimization, pharmacokinetics, and advocacy, with each outlining collaborative nutrition research priorities for the next five years. This forum represents a critical point in pediatric oncology nutrition research as it established the first coordinated and internationally endorsed roadmap to bridge gaps in cancer care and ensure standard nutrition care worldwide. The research priorities and collaborations will help in creating evidence to improve cancer treatment and survival rate for children globally. FAU - Gala, Rajul M AU - Gala RM AUID- ORCID: 0009-0006-3365-1143 AD - Division of Paediatric Oncology, Tata Memorial Centre, Mumbai 400 012, India. FAU - Schoeman, Judy AU - Schoeman J AUID- ORCID: 0000-0002-6154-3653 AD - Division of Paediatric Oncology and Haematology, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, University of Pretoria, Pretoria 0001, South Africa. AD - Department of Pediatrics and Child Health, Faculty of Medicine and Health Science, Stellenbosch University, Stellenbosch 7505, South Africa. FAU - Revuelta Iniesta, Raquel AU - Revuelta Iniesta R AUID- ORCID: 0000-0002-5534-7146 AD - Public Health and Sports Sciences, Faculty of Life and Health Sciences, Medical School, University of Exeter, Exeter EX2 4TE, UK. AD - Child Life and Health, University of Edinburgh, Edinburgh EH16 4TJ, UK. FAU - van den Brink, Mirjam AU - van den Brink M AUID- ORCID: 0000-0001-6758-8978 AD - Princess Maxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands. FAU - Lovell, Amy L AU - Lovell AL AUID- ORCID: 0000-0002-1708-9633 AD - Department of Nutrition and Dietetics, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand. AD - Starship Blood and Cancer Centre, Starship Child Health, Te Whatu Ora, Te Toka Tumai, Auckland 1142, New Zealand. FAU - Huibers, Minke H W AU - Huibers MHW AUID- ORCID: 0000-0003-0310-3067 AD - Department of Pediatrics and Child Health, Faculty of Medicine and Health Science, Stellenbosch University, Stellenbosch 7505, South Africa. AD - Princess Maxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands. AD - Global Child Health Group, Amsterdam University Centre, 1100 DD Amsterdam, The Netherlands. CN - SIOP Nutrition Network Research Forum LA - eng PT - Conference Proceedings DEP - 20260330 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Child MH - Humans MH - *Biomedical Research MH - Global Health MH - Medical Oncology MH - *Neoplasms/therapy MH - Nutrition Assessment MH - Nutritional Status MH - *Pediatrics PMC - PMC13075039 OTO - NOTNLM OT - cancer in children OT - meeting report OT - nutrition OT - nutrition research forum OT - pediatric oncology COIS- The authors declare no conflicts of interest, and the funders of the meeting had no role in the planning or finalizing of the agenda of the Nutrition Research Forum Meeting; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/04/14 06:31 MHDA- 2026/04/14 06:32 PMCR- 2026/03/30 CRDT- 2026/04/14 01:11 PHST- 2026/02/09 00:00 [received] PHST- 2026/03/20 00:00 [revised] PHST- 2026/03/26 00:00 [accepted] PHST- 2026/04/14 06:32 [medline] PHST- 2026/04/14 06:31 [pubmed] PHST- 2026/04/14 01:11 [entrez] PHST- 2026/03/30 00:00 [pmc-release] AID - nu18071112 [pii] AID - nutrients-18-01112 [pii] AID - 10.3390/nu18071112 [doi] PST - epublish SO - Nutrients. 2026 Mar 30;18(7):1112. doi: 10.3390/nu18071112. PMID- 41978088 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 7 DP - 2026 Mar 25 TI - Family Eating Habits and Dietary Quality of Spanish Children and Adolescents: The PASOS Study. LID - 10.3390/nu18071038 [doi] LID - 1038 AB - Background: Childhood nutrition is essential for development and disease prevention. Parental dietary practices and sociodemographic factors shape children's eating habits. Objective: To assess the association between parental diet quality, children's diet, and nutritional status, as well as the influence of caregiver sociodemographic factors. Design: Cross-sectional analyses were conducted using data from two waves of the PASOS study (2019-2020 and 2022-2023), which are nationally representative multicentre observational surveys. The analyses were restricted to participants with complete information on parental diet quality, children's diet quality, and relevant covariates. Methods: Participants aged 8-16 years from the PASOS 2019-2020 (n = 1028) and 2022-2023 (n = 572) studies were included. Caregivers provided sociodemographic information and completed the Short Diet Quality Screener (SDQS), a validated questionnaire to assess parental diet quality. Children's diet quality was assessed using the validated KIDMED index. Based on parental SDQS scores, participants were classified into low (50th percentile) diet quality groups. Associations were analysed using logistic regression and Pearson correlation. Results: Higher parental diet quality was consistently associated with greater adherence to the Mediterranean diet and higher consumption of fruit, breakfast cereals, and fish among children in both study waves. Children whose caregivers had better diet quality also showed a lower prevalence of abdominal obesity. Parental diet quality was positively associated with children's diet quality and inversely related to several adiposity indicators, although associations with anthropometric measures were generally weak. Conclusions: Family-based approaches are essential for improving diet quality and preventing childhood obesity. FAU - Rodenas-Munar, Marina AU - Rodenas-Munar M AUID- ORCID: 0009-0009-0954-039X AD - Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain. AD - Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain. FAU - Garcia, Silvia AU - Garcia S AUID- ORCID: 0000-0003-3534-1588 AD - Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain. AD - Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain. FAU - Gomez, Santiago F AU - Gomez SF AUID- ORCID: 0000-0003-3352-2510 AD - Gasol Foundation Europe, 08830 Sant Boi de Llobregat, Spain. AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain. AD - Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar Institute for Medical Research, 08003 Barcelona, Spain. AD - Nursing and Physiotherapy Department, University of Lleida, 25198 Lleida, Spain. FAU - Gonzalez-Gross, Marcela AU - Gonzalez-Gross M AUID- ORCID: 0000-0001-7757-3235 AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain. AD - ImFINE Research Group, Department of Health and Human Performance, Universidad Politecnica de Madrid, 28040 Madrid, Spain. FAU - Warnberg, Julia AU - Warnberg J AUID- ORCID: 0000-0002-8408-316X AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain. AD - EpiPHAAN Research Group, Faculty of Health Sciences, Universidad de Malaga-Instituto de Investigacion Biomedica de Malaga (IBIMA Bionand), 28590 Malaga, Spain. FAU - Gusi, Narcis AU - Gusi N AUID- ORCID: 0000-0002-1001-8883 AD - Physical Activity and Quality of Life Research Group (AFYCAV), Faculty of Sport Sciences, University of Extremadura, 10003 Caceres, Spain. AD - Instituto de Investigacion e Innovacion en el Deporte (INIDE), 10003 Caceres, Spain. FAU - Aznar, Susana AU - Aznar S AUID- ORCID: 0000-0001-7054-436X AD - PAFS Research Group, Faculty of Sports Sciences, University of Castilla-La Mancha-Toledo Campus, 45071 Toledo, Spain. FAU - Marin-Cascales, Elena AU - Marin-Cascales E AD - UCAM Research Center for High Performance Sport, Universidad Catolica de Murcia, 30107 Murcia, Spain. AD - Faculty of Sport, Universidad Catolica de Murcia, 30107 Murcia, Spain. FAU - Gonzalez-Valeiro, Miguel Angel AU - Gonzalez-Valeiro MA AUID- ORCID: 0000-0002-3993-8069 AD - Faculty of Sports Sciences and Physical Education, Universidade da Coruna, 15071 A Coruna, Spain. FAU - Pulgar, Susana AU - Pulgar S AUID- ORCID: 0000-0002-6845-248X AD - Regional Unit of Sports Medicine of Principado de Asturias, Fundacion Deportiva Municipal de Aviles, 33401 Aviles, Spain. FAU - Bautista, Inmaculada AU - Bautista I AUID- ORCID: 0000-0001-9257-8739 AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain. AD - Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, 35016 Las Palmas, Spain. AD - Preventive Medicine Service, Centro Hospitalario Universitario Insular Materno Infantil (CHUIMI), Canarian Health Service, 35016 Las Palmas, Spain. FAU - Oses, Maddi AU - Oses M AD - ELIKOS Group, Institute for Sustainability and Food Chain Innovation (IS-FOOD), Department of Health Sciences, Public University of Navarre, 31006 Pamplona, Spain. FAU - Cereijo, Luis AU - Cereijo L AUID- ORCID: 0000-0003-2118-3806 AD - Public Health and Epidemiology Research Group, School of Medicine and Health Sciences, Universidad de Alcala, 28871 Alcala de Henares, Spain. FAU - Martin-Oliveros, Adela AU - Martin-Oliveros A AD - Sociedad Espanola de Farmacia Clinica, Familiar y Comunitaria (SEFAC), 28045 Madrid, Spain. FAU - Fito, Montse AU - Fito M AD - Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar Institute for Medical Research, 08003 Barcelona, Spain. FAU - Berruezo, Paula AU - Berruezo P AUID- ORCID: 0009-0002-6355-6463 AD - Gasol Foundation Europe, 08830 Sant Boi de Llobregat, Spain. AD - Public Health and Epidemiology Research Group, School of Medicine and Health Sciences, Universidad de Alcala, 28871 Alcala de Henares, Spain. FAU - Zapico, Augusto G AU - Zapico AG AUID- ORCID: 0000-0001-6157-4997 AD - ImFINE Research Group, Department of Health and Human Performance, Universidad Politecnica de Madrid, 28040 Madrid, Spain. FAU - Benavente-Marin, Juan Carlos AU - Benavente-Marin JC AUID- ORCID: 0000-0002-4037-0239 AD - EpiPHAAN Research Group, Faculty of Health Sciences, Universidad de Malaga-Instituto de Investigacion Biomedica de Malaga (IBIMA Bionand), 28590 Malaga, Spain. FAU - Sanchez Gomez, Jesus AU - Sanchez Gomez J AD - Physical Activity and Quality of Life Research Group (AFYCAV), Faculty of Sport Sciences, University of Extremadura, 10003 Caceres, Spain. AD - Instituto de Investigacion e Innovacion en el Deporte (INIDE), 10003 Caceres, Spain. FAU - Martin-Moraleda, Evelyn AU - Martin-Moraleda E AUID- ORCID: 0000-0002-3769-0522 AD - PAFS Research Group, Faculty of Sports Sciences, University of Castilla-La Mancha-Toledo Campus, 45071 Toledo, Spain. FAU - Alcaraz, Pedro E AU - Alcaraz PE AUID- ORCID: 0000-0002-9792-6656 AD - UCAM Research Center for High Performance Sport, Universidad Catolica de Murcia, 30107 Murcia, Spain. AD - Faculty of Sport, Universidad Catolica de Murcia, 30107 Murcia, Spain. FAU - Sevilla-Sanchez, Marta AU - Sevilla-Sanchez M AUID- ORCID: 0000-0003-2004-9162 AD - Faculty of Sports Sciences and Physical Education, Universidade da Coruna, 15071 A Coruna, Spain. FAU - Herrera-Ramos, Estefania AU - Herrera-Ramos E AUID- ORCID: 0000-0002-5814-3931 AD - Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, 35016 Las Palmas, Spain. FAU - Labayen, Idoia AU - Labayen I AUID- ORCID: 0000-0002-4334-3287 AD - ELIKOS Group, Institute for Sustainability and Food Chain Innovation (IS-FOOD), Department of Health Sciences, Public University of Navarre, 31006 Pamplona, Spain. FAU - Carmona-Rosado, Luis AU - Carmona-Rosado L AD - Public Health and Epidemiology Research Group, School of Medicine and Health Sciences, Universidad de Alcala, 28871 Alcala de Henares, Spain. FAU - Mateos-Lardies, Ana AU - Mateos-Lardies A AUID- ORCID: 0009-0005-8607-0839 AD - Sociedad Espanola de Farmacia Clinica, Familiar y Comunitaria (SEFAC), 28045 Madrid, Spain. FAU - Schroder, Helmut AU - Schroder H AUID- ORCID: 0000-0003-2231-5081 AD - Gasol Foundation Europe, 08830 Sant Boi de Llobregat, Spain. AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain. AD - Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar Institute for Medical Research, 08003 Barcelona, Spain. FAU - Bouzas, Cristina AU - Bouzas C AUID- ORCID: 0000-0002-1407-8461 AD - Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain. AD - Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain. FAU - Tur, Josep A AU - Tur JA AUID- ORCID: 0000-0002-6940-0761 AD - Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain. AD - Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain. LA - eng GR - CIBEROBN CB12/03/30038/Instituto de Salud Carlos III/ GR - CIBERESP CB22/03/00058/Instituto de Salud Carlos III/ GR - N/A/European Regional Development Fund/ GR - N/A/Fundacion PROBITAS/ GR - N/A/Gasol Foundation/ GR - N/A/FC Barcelona Foundation/ GR - N/A/Banco Santander/ GR - N/A/IFA/ GR - N/A/Vienna/ GR - N/A/Fundacion Deporte Joven/ GR - FOLIUM, PRIMUS, SYNERGIA and LIBERI/IDISBA/ GR - Red EXERNET-Red de Ejercicio Fisico y Salud (RED2022-134800-T)/Agencia Estatal de Investigacion (Ministerio de Ciencias e Innovacion, Spain)/ PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20260325 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - Adolescent MH - Spain/epidemiology MH - Cross-Sectional Studies MH - *Feeding Behavior MH - Nutritional Status MH - *Diet MH - Parents MH - *Diet, Healthy/statistics & numerical data MH - Diet, Mediterranean MH - Child Nutritional Physiological Phenomena MH - Socioeconomic Factors PMC - PMC13074208 OTO - NOTNLM OT - adolescents OT - childhood obesity OT - children OT - parents OT - quality of diet OT - sociodemographic factors COIS- The authors declare no conflicts of interest. EDAT- 2026/04/14 06:32 MHDA- 2026/04/14 06:33 PMCR- 2026/03/25 CRDT- 2026/04/14 01:10 PHST- 2026/02/24 00:00 [received] PHST- 2026/03/18 00:00 [revised] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/04/14 06:33 [medline] PHST- 2026/04/14 06:32 [pubmed] PHST- 2026/04/14 01:10 [entrez] PHST- 2026/03/25 00:00 [pmc-release] AID - nu18071038 [pii] AID - nutrients-18-01038 [pii] AID - 10.3390/nu18071038 [doi] PST - epublish SO - Nutrients. 2026 Mar 25;18(7):1038. doi: 10.3390/nu18071038. PMID- 41978080 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 7 DP - 2026 Mar 24 TI - Psychometric Properties and Factor Structure of the Polish ChEDE-Q in a Community Sample of Adolescents: Associations with BMI. LID - 10.3390/nu18071028 [doi] LID - 1028 AB - BACKGROUND: The Child and Adolescent Eating Disorder Examination Questionnaire (ChEDE-Q) is a widely used self-report screening instrument for assessing eating disorder psychopathology in young people. Evidence on the psychometric properties of the Polish-language version remains limited. This pilot study evaluated the internal consistency, dimensional structure, and BMI-related convergent validity of the Polish ChE-DE-Q in a regional youth sample. METHODS: A cross-sectional design was used, including 200 participants aged 10-18 years. Item characteristics and data quality were examined. Internal consistency was assessed using Cronbach's alpha and McDonald's omega. Dimensional structure was evaluated with exploratory factor analysis (EFA) based on a polychoric correlation matrix and confirmatory factor analysis (CFA) comparing one-factor, four-factor, and bifactor models. Convergent validity was examined using Spearman's rank correlations with BMI and linear regression analyses with BMI z-scores. RESULTS: The global score showed high internal consistency (alpha = 0.898; omega = 0.900). Subscale reliability ranged from acceptable to high. EFA supported a multidimensional solution. In CFA, the bifactor model showed the best fit among the tested alternatives (CFI = 0.742; TLI = 0.681; RMSEA = 0.122; SRMR = 0.084), but none of the tested models achieved fully satisfactory absolute fit. The global score correlated positively with BMI (rho = 0.282; p < 0.001) and was significantly associated with BMI z-score in regression analysis (B = 0.334; p < 0.001). CONCLUSIONS: The Polish ChEDE-Q global score demonstrated strong internal consistency and preliminary BMI-related convergent validity. The findings provide initial support for a general factor and for using the global score in screening-oriented research; however, the pilot character of the study and the suboptimal absolute fit indices indicate that further validation in larger and more heterogeneous samples is required. FAU - Wasacz, Malgorzata AU - Wasacz M AD - Department of Medical Communication and Professional Competency Development, Faculty of Medicine, University of Rzeszow, 35-959 Rzeszow, Poland. FAU - Frej, Damian AU - Frej D AUID- ORCID: 0000-0003-1899-4712 AD - Department of Automotive Engineering and Transport, Kielce University of Technology, 25-314 Kielce, Poland. FAU - Ochojska, Danuta AU - Ochojska D AD - Faculty of Health Sciences and Psychology, University of Rzeszow, 35-959 Rzeszow, Poland. FAU - Kopanska, Marta AU - Kopanska M AUID- ORCID: 0000-0003-3936-0698 AD - Department of Medical Communication and Professional Competency Development, Faculty of Medicine, University of Rzeszow, 35-959 Rzeszow, Poland. LA - eng PT - Journal Article DEP - 20260324 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Psychometrics MH - Adolescent MH - Female MH - Child MH - *Body Mass Index MH - Poland MH - Reproducibility of Results MH - Cross-Sectional Studies MH - Male MH - Pilot Projects MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Factor Analysis, Statistical MH - Surveys and Questionnaires PMC - PMC13074324 OTO - NOTNLM OT - BMI OT - ChEDE-Q OT - child eating questionnaire OT - children and adolescents OT - eating disorders OT - psychometric properties COIS- The authors declare that this research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/14 06:32 MHDA- 2026/04/14 06:33 PMCR- 2026/03/24 CRDT- 2026/04/14 01:10 PHST- 2026/02/24 00:00 [received] PHST- 2026/03/19 00:00 [revised] PHST- 2026/03/20 00:00 [accepted] PHST- 2026/04/14 06:33 [medline] PHST- 2026/04/14 06:32 [pubmed] PHST- 2026/04/14 01:10 [entrez] PHST- 2026/03/24 00:00 [pmc-release] AID - nu18071028 [pii] AID - nutrients-18-01028 [pii] AID - 10.3390/nu18071028 [doi] PST - epublish SO - Nutrients. 2026 Mar 24;18(7):1028. doi: 10.3390/nu18071028. PMID- 41978069 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 7 DP - 2026 Mar 24 TI - Weight Perception and Lifestyle Awareness in Children and Adolescents: Insights from a Cross-Sectional Study. LID - 10.3390/nu18071017 [doi] LID - 1017 AB - Background: Misperception of body weight has been found to negatively impact both diet and physical activity levels, particularly in youth with overweight and obesity. Objectives: This study assessed consistency between actual and perceived weight status and lifestyle factors in a sample of 455 children and adolescents (55% males, 8-13 years) attending a summer camp in Northern Italy. Methods: Weight status was defined applying Body Mass Index (BMI) cut-offs. Adherence to the Mediterranean Diet (MD), physical activity level, sleep duration, and sleep quality were assessed through validated questionnaires. Self-perception was evaluated through 5-point Likert scales, with graphical representations. Results: Comparison between self-perceived and assessed parameters revealed a poor concordance across all types of variables. Approximately half of participants (43-55%) correctly rated their weight status (kappa = 0.12; 95% CI: 0.05-0.19), diet quality (kappa = 0.09; 95% CI: 0.02-0.15), physical activity level (kappa = 0.18; 95% CI: 0.11-0.26), sleep time (kappa = 0.10; 95% CI: 0.03-0.17), and sleep quality (kappa = 0.18; 95% CI: 0.12-0.24). Participants 12-13 years old were more likely to have a greater weight status perception compared to younger subjects (OR = 2.13; 95% CI: 1.08-4.21). Being in a condition of overweight or obesity significantly decreased the odds of correct weight perception (OR = 0.13; 95% CI: 0.08-0.21). Similarly, subjects with higher adherence to the MD, adequate sleep time, and low sleep quality were more conscious about their diet and sleep patterns. Conclusions: Overall, these findings highlight a certain degree of misclassification, especially in subjects who need to improve their lifestyles, highlighting the potential relevance of fostering accurate self-perception during developmental age. FAU - Franchini, Cinzia AU - Franchini C AUID- ORCID: 0000-0003-4886-7431 AD - Human Nutrition Unit, Department of Food and Drug, University of Parma, 39 Via Volturno, 43125 Parma, Italy. FAU - Bertolotti, Elena AU - Bertolotti E AD - Human Nutrition Unit, Department of Food and Drug, University of Parma, 39 Via Volturno, 43125 Parma, Italy. FAU - Biasini, Beatrice AU - Biasini B AUID- ORCID: 0000-0002-2928-0961 AD - Human Nutrition Unit, Department of Food and Drug, University of Parma, 39 Via Volturno, 43125 Parma, Italy. FAU - De Panfilis, Chiara AU - De Panfilis C AD - Unit of Neuroscience, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy. FAU - Esposito, Susanna AU - Esposito S AUID- ORCID: 0000-0003-4103-2837 AD - Pediatric Clinic, Parma University Hospital, Department of Medicine and Surgery, University of Parma, Viale Gramsci 14, 43126 Parma, Italy. FAU - Rosi, Alice AU - Rosi A AUID- ORCID: 0000-0001-8533-797X AD - Human Nutrition Unit, Department of Food and Drug, University of Parma, 39 Via Volturno, 43125 Parma, Italy. FAU - Scazzina, Francesca AU - Scazzina F AUID- ORCID: 0000-0002-5372-8658 AD - Human Nutrition Unit, Department of Food and Drug, University of Parma, 39 Via Volturno, 43125 Parma, Italy. AD - Giocampus Scientific Committee, 38 Parco Area delle Scienze, 43124 Parma, Italy. LA - eng PT - Journal Article DEP - 20260324 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - Male MH - Child MH - Cross-Sectional Studies MH - Female MH - *Life Style MH - Exercise MH - *Body Weight MH - Body Mass Index MH - *Self Concept MH - Sleep Duration MH - *Body Image/psychology MH - Surveys and Questionnaires MH - Diet, Mediterranean MH - Italy MH - Sleep MH - Overweight/psychology MH - *Health Knowledge, Attitudes, Practice MH - Sleep Quality PMC - PMC13074309 OTO - NOTNLM OT - BMI OT - KIDMED OT - body image OT - camps OT - food habits OT - lifestyle OT - physical activity OT - self-perception OT - sleep quality COIS- The authors declare no conflicts of interest. EDAT- 2026/04/14 06:31 MHDA- 2026/04/14 06:32 PMCR- 2026/03/24 CRDT- 2026/04/14 01:10 PHST- 2026/02/06 00:00 [received] PHST- 2026/03/17 00:00 [revised] PHST- 2026/03/20 00:00 [accepted] PHST- 2026/04/14 06:32 [medline] PHST- 2026/04/14 06:31 [pubmed] PHST- 2026/04/14 01:10 [entrez] PHST- 2026/03/24 00:00 [pmc-release] AID - nu18071017 [pii] AID - nutrients-18-01017 [pii] AID - 10.3390/nu18071017 [doi] PST - epublish SO - Nutrients. 2026 Mar 24;18(7):1017. doi: 10.3390/nu18071017. PMID- 41976791 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260414 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 7 DP - 2026 Mar 24 TI - Prediction of In-Hospital Respiratory Support Among Children Aged 2-59 Months Hospitalized with Pneumonia in Southern Vietnam: A Retrospective Cohort Study. LID - 10.3390/jcm15072490 [doi] LID - 2490 AB - Respiratory support requirement among children hospitalized with pneumonia is a key marker of disease severity and resource needs, yet scalable risk stratification tools for routine hospital settings in Southern Vietnam remain limited. Background: This study aimed to develop and evaluate clinical and laboratory-based multivariable models to predict respiratory support requirement in children under five hospitalized with pneumonia, using a routine care dataset. Methods: We conducted a retrospective cohort study conducted at a tertiary pediatric hospital in Southern Vietnam (July 2024-November 2025), children aged 2-59 months hospitalized with pneumonia were included after predefined exclusions. The outcome was the maximum (worst) level of respiratory support required during hospitalization (oxygen therapy, CPAP, or invasive mechanical ventilation), analyzed as a binary endpoint (any support vs. none) for model development. Candidate predictors included bedside clinical variables (age < 12 months, malnutrition, recurrent pneumonia, cyanosis, tachypnea, chest indrawing) and complete blood count-derived inflammatory indices. Univariable logistic regression was used for crude associations. Two multivariable logistic regression models were built: Model 1 (clinical-only) and Model 2 (clinical + neutrophil-to-lymphocyte ratio [NLR]; primary). Discrimination was assessed using area under the ROC curve (AUC), and calibration was evaluated using the Hosmer-Lemeshow test and observed-to-expected (O:E) ratio. Results: A total of 1797 children were included; 154 (8.6%) required respiratory support. In the primary model, independent predictors were age < 12 months (aOR 2.57, 95% CI 1.69-3.92), malnutrition (aOR 4.33, 2.56-7.33), recurrent pneumonia (aOR 1.82, 1.18-2.81), cyanosis (aOR 24.02, 7.41-77.87), chest indrawing (aOR 4.19, 2.73-6.43), and higher NLR (per 1 unit: aOR 1.49, 1.38-1.60), while tachypnea was not independently associated after adjustment. Discrimination improved from Model 1 (AUC 0.754) to Model 2 (AUC 0.840; 95% CI 0.806-0.874). At the optimal probability cut-off (0.122), Model 2 achieved sensitivity 66.2%, specificity 86.2%, PPV 31.1%, NPV 96.5%, and accuracy 84.5%. Calibration was acceptable (Hosmer-Lemeshow p = 0.662; O:E = 1.00). Conclusions: A simple clinical model strengthened by NLR provided good discrimination and calibration for predicting respiratory support requirement among children under-five hospitalized with pneumonia in Southern Vietnam. This approach may support early triage, prioritization of monitoring intensity, and escalation readiness in resource-constrained settings, although external validation is warranted. FAU - Vo, Thi Van AU - Vo TV AUID- ORCID: 0009-0008-8377-0217 AD - Department of Pediatrics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, No. 179 Nguyen Van Cu Street, Tan An Ward, Can Tho 900000, Vietnam. FAU - Nguyen, Phuong Minh AU - Nguyen PM AUID- ORCID: 0000-0002-3857-9420 AD - Department of Pediatrics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, No. 179 Nguyen Van Cu Street, Tan An Ward, Can Tho 900000, Vietnam. FAU - Lu, Dien Tri AU - Lu DT AUID- ORCID: 0009-0009-8025-3692 AD - Internal Medicine Program, Department of General Nursing, Faculty of Nursing and Medical Technology, Can Tho University of Medicine and Pharmacy, No. 179 Nguyen Van Cu Street, Tan An Ward, Can Tho 900000, Vietnam. FAU - Ong, Thanh Huy AU - Ong TH AUID- ORCID: 0009-0006-2815-2278 AD - Can Tho Children's Hospital, No. 345 Nguyen Van Cu Street, An Binh Ward, Can Tho 900000, Vietnam. FAU - Nguyen, Tri Duc AU - Nguyen TD AUID- ORCID: 0009-0003-9356-6846 AD - Can Tho Children's Hospital, No. 345 Nguyen Van Cu Street, An Binh Ward, Can Tho 900000, Vietnam. FAU - Thai, Dien Minh AU - Thai DM AUID- ORCID: 0009-0000-7007-8485 AD - Faculty of Medicine, Nam Can Tho University, No. 168 Nguyen Van Cu Street, An Binh Ward, Can Tho 900000, Vietnam. FAU - Tran, Duc Hoang Minh AU - Tran DHM AUID- ORCID: 0009-0006-0400-8773 AD - Department of Pediatrics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, No. 179 Nguyen Van Cu Street, Tan An Ward, Can Tho 900000, Vietnam. LA - eng PT - Journal Article DEP - 20260324 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13073457 OTO - NOTNLM OT - Vietnam OT - child OT - logistic regression OT - neutrophil-to-lymphocyte ratio OT - pneumonia OT - respiratory support OT - risk prediction COIS- The authors declare no conflict of interest. EDAT- 2026/04/14 06:31 MHDA- 2026/04/14 06:32 PMCR- 2026/03/24 CRDT- 2026/04/14 01:06 PHST- 2026/01/23 00:00 [received] PHST- 2026/03/10 00:00 [revised] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/04/14 06:32 [medline] PHST- 2026/04/14 06:31 [pubmed] PHST- 2026/04/14 01:06 [entrez] PHST- 2026/03/24 00:00 [pmc-release] AID - jcm15072490 [pii] AID - jcm-15-02490 [pii] AID - 10.3390/jcm15072490 [doi] PST - epublish SO - J Clin Med. 2026 Mar 24;15(7):2490. doi: 10.3390/jcm15072490. PMID- 41975844 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260414 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 7 DP - 2026 Mar 25 TI - Attitudes Towards Sport in Early Adolescence: A Scale Adaptation Study for Sustainable Good Health and Well-Being. LID - 10.3390/healthcare14070842 [doi] LID - 842 AB - BACKGROUND: The decline in physical activity during the transition to early adolescence poses a significant threat to lifelong health and well-being, directly impacting the targets of Sustainable Development Goal 3 (SDG 3). To design effective preventive interventions, researchers need developmentally appropriate tools to measure the psychological drivers of physical activity. OBJECTIVES: This study aimed to adapt the Attitude Towards Sport Scale (ATSS) for middle school students (ages 10-15) and evaluate its psychometric properties. METHODS: We used a mixed-methods approach comprising a qualitative cognitive think-aloud phase (n = 27) and a quantitative cross-sectional validation phase (N = 531). Data were analyzed using robust Confirmatory Factor Analysis (CFA). RESULTS: The results supported the structural model, demonstrating that the original three-factor structure fits the early adolescent sample acceptably. The scale demonstrated high composite reliability across all dimensions. Furthermore, the adapted ATSS-EA showed strong criterion-related validity through high correlations with perceived physical literacy and actual physical activity durations. It also successfully differentiated between licensed athletes and non-licensed students. CONCLUSIONS: The adapted ATSS-EA provides a developmentally appropriate tool for educators and researchers to monitor sport attitudes and identify students at risk of physical disengagement. FAU - Senturk, Halil Evren AU - Senturk HE AUID- ORCID: 0000-0001-7402-0758 AD - Faculty of Sport Sciences, Mugla Sitki Kocman University, Mugla 48000, Turkiye. FAU - Tanir, Gulsum AU - Tanir G AD - Institute of Health Sciences, Mugla Sitki Kocman University, Mugla 48000, Turkiye. FAU - Erdogan Yuce, Ulkum AU - Erdogan Yuce U AD - Ministry of National Education, Mugla 48700, Turkiye. FAU - Karatut, Adem AU - Karatut A AUID- ORCID: 0000-0003-1927-5656 AD - Ministry of National Education, Kocaeli 41050, Turkiye. FAU - Karakas, Ecesu AU - Karakas E AD - Faculty of Sport Sciences, Mugla Sitki Kocman University, Mugla 48000, Turkiye. LA - eng PT - Journal Article DEP - 20260325 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13073176 OTO - NOTNLM OT - early adolescence OT - good health OT - health-lifestyle behaviors OT - physical activity OT - physical literacy OT - preventive healthcare OT - psychometrics OT - scale adaptation OT - sports attitude OT - well-being COIS- The authors declare no conflicts of interest. EDAT- 2026/04/14 06:31 MHDA- 2026/04/14 06:32 PMCR- 2026/03/25 CRDT- 2026/04/14 01:02 PHST- 2026/03/07 00:00 [received] PHST- 2026/03/20 00:00 [revised] PHST- 2026/03/20 00:00 [accepted] PHST- 2026/04/14 06:32 [medline] PHST- 2026/04/14 06:31 [pubmed] PHST- 2026/04/14 01:02 [entrez] PHST- 2026/03/25 00:00 [pmc-release] AID - healthcare14070842 [pii] AID - healthcare-14-00842 [pii] AID - 10.3390/healthcare14070842 [doi] PST - epublish SO - Healthcare (Basel). 2026 Mar 25;14(7):842. doi: 10.3390/healthcare14070842. PMID- 41974915 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Apr 13 TI - The chain mediating effects of psychological resilience and social adaptability on the relationship between physical activity and mental health in Chinese university students. LID - 10.1038/s41598-026-48168-0 [doi] LID - 17197 AB - Mental health issues among university students have attracted increasing attention, underscoring the need to identify modifiable protective factors. This cross-sectional study examined the association between physical activity (PA) and mental health (MH) among Chinese university students, with a focus on the mediating roles of psychological resilience (PR) and social adaptability (SA). A sample of 519 students from three universities in the Beijing-Tianjin-Hebei region completed validated questionnaires assessing PA (Physical Activity Rating Scale-3), MH (12-item General Health Questionnaire), PR (Adolescent Psychological Resilience Scale), and SA (Social Adaptability Scale). Pearson correlation analysis and structural equation modeling with Bootstrap methods were employed to test direct and indirect effects. Results revealed that PA was positively correlated with PR, SA, and MH. PR and SA independently mediated the PA-MH relationship, and a significant sequential mediation pathway (PA --> PR --> SA --> MH) was observed, indicating that PA was associated with better MH through the chain effects of PR and SA. These findings suggest that the MH benefits of PA may operate not only directly but also through an association with enhanced internal psychological resources and external SA. University health programs that integrate PA with resilience and social-skills interventions may help improve student MH. CI - (c) 2026. The Author(s). FAU - Liu, Wanxu AU - Liu W AD - School of the Arts, Beijing Sport University, 48 Xinxi Road, Haidian District, Beijing, 100084, China. FAU - Wang, Zilin AU - Wang Z AD - School of Sport Science, Beijing Sport University, 48 Xinxi Road, Haidian District, Beijing, 100084, China. FAU - Hou, Xinyi AU - Hou X AD - School of the Arts, Beijing Sport University, 48 Xinxi Road, Haidian District, Beijing, 100084, China. FAU - Sun, Yuanxin AU - Sun Y AD - School of the Arts, Beijing Sport University, 48 Xinxi Road, Haidian District, Beijing, 100084, China. FAU - Xu, Ke AU - Xu K AD - School of the Arts, Beijing Sport University, 48 Xinxi Road, Haidian District, Beijing, 100084, China. 13810933757@163.com. LA - eng GR - No. 2106056/The 2024 Beijing Sport University Research Project on Ideological and Political Work for College Students/ PT - Journal Article DEP - 20260413 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Students/psychology MH - *Mental Health MH - *Resilience, Psychological MH - Female MH - Universities MH - *Exercise/psychology MH - Male MH - Young Adult MH - China MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - *Social Adjustment MH - Adolescent MH - Adult PMC - PMC13234124 OTO - NOTNLM OT - Chinese University Students OT - Mediation OT - Mental Health OT - Physical Activity OT - Psychological Resilience OT - Social Adaptability COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/04/14 00:31 MHDA- 2026/06/11 06:40 PMCR- 2026/04/13 CRDT- 2026/04/13 23:27 PHST- 2026/01/26 00:00 [received] PHST- 2026/04/06 00:00 [accepted] PHST- 2026/06/11 06:40 [medline] PHST- 2026/04/14 00:31 [pubmed] PHST- 2026/04/13 23:27 [entrez] PHST- 2026/04/13 00:00 [pmc-release] AID - 10.1038/s41598-026-48168-0 [pii] AID - 48168 [pii] AID - 10.1038/s41598-026-48168-0 [doi] PST - epublish SO - Sci Rep. 2026 Apr 13;16(1):17197. doi: 10.1038/s41598-026-48168-0. PMID- 41970416 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260413 LR - 20260813 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 4 DP - 2026 Apr TI - Maternal Knowledge, Attitudes, and Practices Toward Complementary Feeding in Rural Bangladesh: A Cross-Sectional Study. PG - e72318 LID - 10.1002/hsr2.72318 [doi] LID - e72318 AB - BACKGROUND: Complementary Feeding is essential for child growth and development, particularly between 6 and 24 months of age, when nutritional demands exceed what breast milk alone can provide. However, persistent gaps remain between maternal knowledge and actual feeding practices in many low- and middle-income countries (LMICs). Inappropriate complementary feeding contributes significantly to child malnutrition in Bangladesh. This study examined the knowledge, attitudes, and practices (KAP) of mothers regarding complementary feeding in a rural area of Tangail, Bangladesh. METHODS: A cross-sectional survey was conducted among 160 mothers of infants aged 6-24 months. Data were collected using a structured questionnaire, guided by World Health Organisation (WHO) recommendations and previously validated KAP instruments. RESULTS: Most mothers (93.1%) had introduced complementary feeding to their children, and 82.5% correctly identified the appropriate age for initiating. Only 66.9% practised adequate hygiene in food preparation, and 93.1% affirmed the importance of nutritious complementary food for proper growth and development. Homemade foods were preferred by 89.4% of mothers, though 16.3% introduced formula milk early. Attitudes toward feeding during illness were mixed. However, 60% of mothers reported offering extra food during illness, which aligns with WHO recommendations. Mothers with higher education and income demonstrated significantly more positive attitudes, and employed mothers and those in nuclear families showed significantly better complementary feeding practices. CONCLUSION: This study found while most mothers in rural Bangladesh know when to initiate complementary feeding, substantial gaps persist in hygiene and feeding practices. Increased community-based and family-centered nutrition education, as well as the integration of growth monitoring into maternal and child health services, are recommended to address observed practice gaps. Further research should explore barriers to applying knowledge in practice. CI - (c) 2026 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Islam, Rajib Ul AU - Islam RU AD - Department of Government and Politics Jahangirnagar University Savar Dhaka Bangladesh. FAU - Mili, Morsheda Alam AU - Mili MA AD - Department of Public Health and Informatics Jahangirnagar University Savar Dhaka Bangladesh. FAU - Kamal, Sabkat AU - Kamal S AUID- ORCID: 0000-0002-6548-4937 AD - Department of Urban and Regional Planning Jahangirnagar University Savar Dhaka Bangladesh. FAU - Taher, Labina AU - Taher L AD - Kelvin Grove State College Brisbane Queensland Australia. FAU - Noshin, Fariha AU - Noshin F AD - Government College of Applied Human Science Dhaka Bangladesh. FAU - Moonajilin, Mst Sabrina AU - Moonajilin MS AUID- ORCID: 0000-0003-4135-9960 AD - Department of Public Health and Informatics Jahangirnagar University Savar Dhaka Bangladesh. AD - Queensland University of Technology, Psychology and counselling Brisbane Australia. LA - eng PT - Journal Article DEP - 20260408 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC13062521 OTO - NOTNLM OT - child nutrition OT - complementary feeding OT - maternal knowledge COIS- The authors declare no conflicts of interest. EDAT- 2026/04/13 18:17 MHDA- 2026/04/13 18:18 PMCR- 2026/04/08 CRDT- 2026/04/13 06:34 PHST- 2025/06/08 00:00 [received] PHST- 2025/12/05 00:00 [revised] PHST- 2026/04/01 00:00 [accepted] PHST- 2026/04/13 18:18 [medline] PHST- 2026/04/13 18:17 [pubmed] PHST- 2026/04/13 06:34 [entrez] PHST- 2026/04/08 00:00 [pmc-release] AID - HSR272318 [pii] AID - 10.1002/hsr2.72318 [doi] PST - epublish SO - Health Sci Rep. 2026 Apr 8;9(4):e72318. doi: 10.1002/hsr2.72318. eCollection 2026 Apr. PMID- 41969967 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260413 LR - 20260813 IS - 1300-0667 (Print) IS - 1309-4866 (Electronic) IS - 1300-0667 (Linking) VI - 63 DP - 2026 TI - Binge Eating Disorder in Bipolar I Disorder: Prevalence, Childhood Trauma, and Clinical Correlates. PG - 380-386 LID - 10.29399/npa.29253 [doi] AB - INTRODUCTION: Bipolar I disorder (BD-I) frequently co-occurs with eating disorders, particularly binge eating disorder (BED), which may adversely affect the clinical course, including recurrence risk and functional impairment. Research exploring the specific association between BED and childhood trauma (CT) in BD-I remains limited. This study aimed to investigate the prevalence of BED among euthymic BD-I patients and to examine its associations with CT and clinical characteristics. METHODS: This cross-sectional study recruited 150 euthymic BD-I patients diagnosed according to DSM-5 criteria. Sociodemographic data, illness-related variables, psychiatric comorbidities, and medication use were collected. Binge eating disorder was assessed through the Structured Clinical Interview for DSM-5 (SCID-5) and validated eating disorder scales. Childhood trauma was evaluated using the Childhood Trauma Questionnaire (CTQ). Statistical analyses included group comparisons and multivariate logistic regression. RESULTS: Binge eating disorder prevalence in the sample was 19.3%. Female sex, higher body weight, and elevated body mass index were significantly associated with BED. Compared to patients without BED, those with BED reported higher rates of psychotic episodes, rapid cycling, and suicide attempts. Childhood trauma questionnaire total scores, particularly physical abuse subscale scores, were significantly higher in the BED group. Logistic regression analysis revealed that female sex, a history of physical abuse, and higher eating disorder scale scores were independent predictors of BED. CONCLUSIONS: Our findings indicate that BED constitutes a distinct and clinically consequential profile in euthymic BD-I patients, one that is strongly shaped by both increased illness severity and CT. This relationship underlines the necessity of integrating systematic assessments of eating pathology and trauma exposure into the standard clinical evaluation of BD-I patients to ensure timely recognition and the delivery of effective, precision-based therapeutic interventions. CI - Copyright: (c) 2026 Turkish Neuropsychiatric Society. FAU - Karabiyik, Binnur AU - Karabiyik B AD - Basaksehir Cam Sakura City Hospital, Department of Psychiatry, Istanbul, Turkiye. FAU - Onur, Ozge Sahmelikoglu AU - Onur OS AD - Tekirdag Namik Kemal University, Department of Psychiatry, Tekirdag, Turkiye. FAU - Karamustafalioglu, Nesrin AU - Karamustafalioglu N AD - 16th Psychiatry Clinic, Bakirkoy Prof. Dr. Mazhar Osman Trainig and Research Hospital for Psychiatry, Neurology and Neurosurgery, Istanbul, Turkiye. LA - eng PT - Journal Article DEP - 20260326 PL - Turkey TA - Noro Psikiyatr Ars JT - Noro psikiyatri arsivi JID - 9426194 PMC - PMC13065102 OTO - NOTNLM OT - Binge eating disorder OT - bipolar disorder OT - childhood trauma OT - eating disorder COIS- Conflict of Interest: The authors declared that there is no conflict of interest. EDAT- 2026/04/13 18:17 MHDA- 2026/04/13 18:18 PMCR- 2026/03/26 CRDT- 2026/04/13 06:30 PHST- 2025/10/01 00:00 [received] PHST- 2026/01/02 00:00 [accepted] PHST- 2026/04/13 18:18 [medline] PHST- 2026/04/13 18:17 [pubmed] PHST- 2026/04/13 06:30 [entrez] PHST- 2026/03/26 00:00 [pmc-release] AID - archneuro-63-380 [pii] AID - 10.29399/npa.29253 [doi] PST - epublish SO - Noro Psikiyatr Ars. 2026 Mar 26;63:380-386. doi: 10.29399/npa.29253. eCollection 2026. PMID- 41969721 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260413 LR - 20260813 IS - 0970-0218 (Print) IS - 1998-3581 (Electronic) IS - 0970-0218 (Linking) VI - 51 IP - Suppl 1 DP - 2026 Feb TI - Weight Perception and Bullying among Overweight and Obese Students (Age 6-16 Years) in Amritsar District. PG - S137-S143 LID - 10.4103/ijcm.ijcm_523_24 [doi] AB - BACKGROUND: Childhood obesity is a serious global health crisis with serious and long-lasting consequences for children's physical and mental health. The persistence of obesity and accompanying health complications is partly due to parents' and children's misperceptions about their weight status. Furthermore, obesity is associated with increased bullying and negative social experiences among school-aged children. OBJECTIVES: The study aims to evaluate the self-perception of weight among overweight and obese students aged 6-16 years in Amritsar and to explore the relationship between obesity and bullying. METHODS: The Amritsar district was selected through the lottery method of simple random sampling for this cross-sectional study, which was carried out between October 2019 and April 2020. Out of 4226 students, 355 overweight and obese students were interviewed regarding their weight perceptions and social impact. After being fully informed of the study's goals and methods, guardians and students gave their written consent to take part. A predesigned, validated, semistructured questionnaire was used to interview mothers of students aged 6 to 11 and students aged 12 to 16. Statistical analysis was done using Chi-square and logistic regression tests. RESULTS: 70.7% received weight loss suggestions from family, with 39.4% from parents. Despite 52.1% attempting weight loss, many found it ineffective. Only 47.3% deemed school education on weight management sufficient. Notably, 53.2% reported their social life has been impacted negatively due to their weight, and 29.9% experienced sadness. Bullying was more prevalent among boys, with 72.9% reporting such experiences. Regression analysis indicated that obesity-related sadness and being aged 14-16 years increased odds of bullying. CONCLUSIONS: Bullying is more prevalent in obese boys, and it is more likely to affect students of age group 14-16 years and those who are depressed about their weight. Many students and their mothers misperceive weight status. Improvements to school canteen food quality, nutrition seminars, and physical education programs are among the recommendations. CI - Copyright: (c) 2026 Indian Journal of Community Medicine. FAU - Batish, Rohit AU - Batish R AD - Department of Community Medicine, GMC and RH, Patiala, Punjab, India. FAU - Oberoi, Simmi AU - Oberoi S AD - Department of Community Medicine, GMC and RH, Patiala, Punjab, India. FAU - Ghosh, Sataparna AU - Ghosh S AD - Department of Community Medicine, GMC and RH, Patiala, Punjab, India. FAU - Singh, Aman Dev AU - Singh AD AD - Department of Community Medicine, GMC and RH, Patiala, Punjab, India. FAU - Ashish, Sneh AU - Ashish S AD - Department of Dental Research Cell, Dr. DY Patil Dental College and Hospital, Dr. DY Patil Vidyapeeth, Pimpri, Pune, Maharashtra, India. LA - eng PT - Journal Article DEP - 20260112 PL - India TA - Indian J Community Med JT - Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine JID - 9315574 PMC - PMC13068427 OTO - NOTNLM OT - Bullying OT - overweight OT - pediatric obesity OT - weight perceptions COIS- There are no conflicts of interest. EDAT- 2026/04/13 18:17 MHDA- 2026/04/13 18:18 PMCR- 2026/02/01 CRDT- 2026/04/13 06:28 PHST- 2024/07/24 00:00 [received] PHST- 2025/09/18 00:00 [accepted] PHST- 2026/04/13 18:18 [medline] PHST- 2026/04/13 18:17 [pubmed] PHST- 2026/04/13 06:28 [entrez] PHST- 2026/02/01 00:00 [pmc-release] AID - IJCM-51-137 [pii] AID - 10.4103/ijcm.ijcm_523_24 [doi] PST - ppublish SO - Indian J Community Med. 2026 Feb;51(Suppl 1):S137-S143. doi: 10.4103/ijcm.ijcm_523_24. Epub 2026 Jan 12. PMID- 41967738 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20260831 IS - 1097-6868 (Electronic) IS - 0002-9378 (Linking) VI - 235 IP - 3 DP - 2026 Sep TI - Consensus and controversies of international guidelines for the diagnosis, surveillance, and management of fetal growth restriction: an updated comparison. PG - 486-505 LID - S0002-9378(26)00188-2 [pii] LID - 10.1016/j.ajog.2026.04.010 [doi] AB - Fetal growth restriction remains a major contributor to perinatal morbidity and mortality, yet its management varies across clinical settings. The aim of this study was to compare areas of consensus and disagreements across contemporary international and national guidelines on the diagnosis, surveillance, and management of fetal growth restriction. Electronic searches of Medline from database inception up to March 2026 using Medical Subject Headings terms and keywords related to fetal growth restriction and guidelines. Critical, structured comparison of national or international guidelines on fetal growth restriction published since 2010. Final inclusion required unanimous agreement from all authors. Prespecified extraction across domains: definition, prediction/prevention, surveillance tools and frequency, delivery timing and mode, and labor induction methods. Dual data checking with consensus resolution. We focused mainly on areas of cross-guideline agreement and divergence in (1) definitions (fetal growth restriction vs small for gestational age; early vs late), (2) diagnostic/surveillance tools (biometry, Doppler, cardiotocography [conventional or computerized], biophysical profile, biomarkers), and (3) management (aspirin/low-molecular-weight heparin, steroids, magnesium sulfate, induction methods, delivery timing/mode). Six guidelines, 3 national (Canada, United Kingdom, and France), 1 US society guideline (Society for Maternal-Fetal Medicine), and 2 international societies (International Society of Ultrasound in Obstetrics and Gynecology and International Federation of Gynecology and Obstetrics) published predominantly between 2015 and 2024 were included. Broad agreement exists on the central role of Doppler-especially umbilical artery and, in early-onset cases, ductus venosus (except for Society for Maternal-Fetal Medicine)-for risk stratification and delivery timing. Other consensus points include antenatal corticosteroids, magnesium sulfate for anticipated preterm birth, early aspirin in high-risk pregnancies, and access to genetic counseling/testing in severe or early-onset fetal growth restriction with structural anomalies. Universal third-trimester ultrasound is not recommended in low-risk pregnancies. Controversies remain on the definition of fetal growth restriction vs small for gestational age (Society for Maternal-Fetal Medicine biometric threshold vs Delphi criteria), routine use of angiogenic biomarkers, low-molecular-weight heparin for prevention, choice of growth charts, the role of the biophysical profile, computerized cardiotocography, and induction methods (mechanical generally favored but with limited evidence). Current guidelines converge on Doppler-based surveillance and standard preterm interventions, but substantial heterogeneity persists in definitions and several management domains, reflecting variable evidence and resource contexts. Priorities include harmonizing definitions, validating surveillance algorithms (notably computerized cardiotocography and ductus venosus), clarifying growth-chart selection, and rigorously testing the added value of angiogenic biomarkers and induction strategies to improve fetal growth restriction outcomes. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Di Mascio, Daniele AU - Di Mascio D AD - Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy. Electronic address: daniele.dimascio@uniroma1.it. FAU - Chauhan, Suneet P AU - Chauhan SP AD - Maternal-Fetal Medicine, Delaware Center of Maternal-Fetal Medicine, Newark, DE. FAU - Ghi, Tullio AU - Ghi T AD - Department of Women and Child Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. FAU - Khalil, Asma AU - Khalil A AD - Fetal Medicine Unit, Liverpool Women Hospital, Liverpool, United Kingdom; Fetal Medicine Unit, St George's Hospital, London, United Kingdom; Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, City St George's University of London, London, United Kingdom. FAU - Martins, Juliana G AU - Martins JG AD - Department of Obstetrics and Gynecology, Macon and Joan Brock Virginia Health Sciences at Old Dominion University (ODU), Norfolk, VA. FAU - Sorrenti, Sara AU - Sorrenti S AD - Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy. FAU - Stampalija, Tamara AU - Stampalija T AD - Unit of Fetal Medicine and Prenatal Diagnosis, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy; Department of Medical Surgical and Health Sciences, University of Trieste, Trieste, Italy. FAU - Zullo, Fabrizio AU - Zullo F AD - Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy. FAU - Figueras, Francesc AU - Figueras F AD - BCNatal (Hospital Clinic and Hospital Sant Joan de Deu), Universitat de Barcelona, Barcelona, Spain. LA - eng PT - Comparative Study PT - Journal Article PT - Review DEP - 20260410 PL - United States TA - Am J Obstet Gynecol JT - American journal of obstetrics and gynecology JID - 0370476 RN - 0 (Biomarkers) RN - R16CO5Y76E (Aspirin) RN - 0 (Heparin, Low-Molecular-Weight) RN - 7487-88-9 (Magnesium Sulfate) SB - IM MH - Humans MH - *Fetal Growth Retardation/diagnosis/therapy MH - Female MH - Pregnancy MH - *Practice Guidelines as Topic MH - Consensus MH - Ultrasonography, Prenatal MH - Cardiotocography MH - Infant, Small for Gestational Age MH - Umbilical Arteries/diagnostic imaging MH - Gestational Age MH - Biomarkers MH - Ultrasonography, Doppler MH - Labor, Induced MH - Aspirin/therapeutic use MH - Heparin, Low-Molecular-Weight/therapeutic use MH - Biometry MH - Magnesium Sulfate/therapeutic use OTO - NOTNLM OT - Doppler OT - ductus venosus OT - fetal growth restriction OT - fetal smallness OT - neonatal morbidity OT - neonatal mortality OT - small for gestational age OT - umbilical artery EDAT- 2026/04/13 00:31 MHDA- 2026/08/19 23:42 CRDT- 2026/04/12 19:36 PHST- 2026/01/13 00:00 [received] PHST- 2026/04/01 00:00 [revised] PHST- 2026/04/07 00:00 [accepted] PHST- 2026/08/19 23:42 [medline] PHST- 2026/04/13 00:31 [pubmed] PHST- 2026/04/12 19:36 [entrez] AID - S0002-9378(26)00188-2 [pii] AID - 10.1016/j.ajog.2026.04.010 [doi] PST - ppublish SO - Am J Obstet Gynecol. 2026 Sep;235(3):486-505. doi: 10.1016/j.ajog.2026.04.010. Epub 2026 Apr 10. PMID- 41966455 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260918 IS - 1530-891X (Print) IS - 1530-891X (Linking) VI - 32 IP - 9 DP - 2026 Sep TI - Thyroid Function and Non-alcoholic Fatty Liver Disease in Children and Adolescent With Obesity: A Systematic Review and Meta-Analysis. PG - 1422-1429 LID - S1530-891X(26)00935-3 [pii] LID - 10.1016/j.eprac.2026.04.002 [doi] AB - OBJECTIVE: The relationship between thyroid function and non-alcoholic fatty liver disease (NAFLD) in pediatric obesity remains incompletely defined. This systematic review and meta-analysis aimed to quantitatively assess the association between thyroid function parameters and NAFLD in children and adolescents with obesity. METHODS: A systematic search of PubMed/MEDLINE, Scopus, and Web of Science was conducted through December 31, 2025. Observational studies evaluating thyroid function in children and adolescents with obesity, stratified by the presence or absence of NAFLD, were included. Hepatic steatosis was diagnosed using imaging, histology, or validated noninvasive scores. Random-effects meta-analyses were performed to compare serum thyroid-stimulating hormone (TSH), free thyroxine, and free triiodothyronine levels between groups. Study quality was assessed using Quality Assessment of Diagnostic Accuracy Studies version 2. RESULTS: Ten studies encompassing 5145 participants were included. Meta-analysis of 6 studies (n= 3076) demonstrated significantly higher TSH levels in patients with NAFLD compared with controls without NAFLD (mean difference 0.37 mIU/L; 95% confidence interval [CI] 0.07-0.66), with moderate heterogeneity (I(2)= 48.7%). No significant differences were observed for free thyroxine (standardized mean difference -0.35; 95% CI -1.15 to 0.45) or free triiodothyronine (standardized mean difference 0.35; 95% CI -0.26 to 0.96). Sensitivity analyses confirmed the robustness of the TSH association. CONCLUSION: In pediatric obesity, NAFLD is associated with higher TSH levels in the absence of significant changes in circulating thyroid hormone concentrations. These findings suggest that hyperthyrotropinaemia may represent a metabolic marker of hepatic steatosis rather than an adaptive physiological response. Prospective studies are needed to clarify causality and clinical implications. CI - Copyright (c) 2026 AACE. Published by Elsevier Inc. All rights reserved. FAU - Gatta, Elisa AU - Gatta E AD - Department of Clinical and Experimental Sciences, SSD Endocrinologia, University of Brescia, ASST Spedali Civili, Brescia, Italy; Centro per la Diagnosi e Cura delle Neoplasie Endocrine e delle Malattie della Tiroide, University of Brescia, Brescia, Italy. FAU - Ugoccioni, Massimiliano AU - Ugoccioni M AD - Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy. FAU - Gandossi, Elena AU - Gandossi E AD - Department of Clinical and Experimental Sciences, SSD Endocrinologia, University of Brescia, ASST Spedali Civili, Brescia, Italy; Centro per la Diagnosi e Cura delle Neoplasie Endocrine e delle Malattie della Tiroide, University of Brescia, Brescia, Italy. FAU - Delbarba, Andrea AU - Delbarba A AD - Department of Clinical and Experimental Sciences, SSD Endocrinologia, University of Brescia, ASST Spedali Civili, Brescia, Italy. FAU - Agosti, Barbara AU - Agosti B AD - SSD Diabetologia, ASST Franciacorta, Chiari, Italy. FAU - Pirola, Ilenia AU - Pirola I AD - Department of Clinical and Experimental Sciences, SSD Endocrinologia, University of Brescia, ASST Spedali Civili, Brescia, Italy; Centro per la Diagnosi e Cura delle Neoplasie Endocrine e delle Malattie della Tiroide, University of Brescia, Brescia, Italy. FAU - Rotondi, Mario AU - Rotondi M AD - Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Pavia, Italy. FAU - Cappelli, Carlo AU - Cappelli C AD - Department of Clinical and Experimental Sciences, SSD Endocrinologia, University of Brescia, ASST Spedali Civili, Brescia, Italy; Centro per la Diagnosi e Cura delle Neoplasie Endocrine e delle Malattie della Tiroide, University of Brescia, Brescia, Italy. Electronic address: carlo.cappelli@unibs.it. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260409 PL - United States TA - Endocr Pract JT - Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists JID - 9607439 RN - 9002-71-5 (Thyrotropin) RN - 06LU7C9H1V (Triiodothyronine) SB - IM MH - Humans MH - *Non-alcoholic Fatty Liver Disease/epidemiology/physiopathology/blood/etiology MH - Adolescent MH - Child MH - *Thyroid Gland/physiopathology MH - *Pediatric Obesity/complications/physiopathology/epidemiology/blood MH - Thyrotropin/blood MH - Thyroid Function Tests MH - Triiodothyronine/blood OTO - NOTNLM OT - NAFLD OT - hepatic steatosis OT - obesity OT - thyroid COIS- Disclosure The authors have no conflicts of interest to disclose. EDAT- 2026/04/12 12:33 MHDA- 2026/09/01 23:34 CRDT- 2026/04/12 10:30 PHST- 2026/02/08 00:00 [received] PHST- 2026/03/23 00:00 [revised] PHST- 2026/04/02 00:00 [accepted] PHST- 2026/09/01 23:34 [medline] PHST- 2026/04/12 12:33 [pubmed] PHST- 2026/04/12 10:30 [entrez] AID - S1530-891X(26)00935-3 [pii] AID - 10.1016/j.eprac.2026.04.002 [doi] PST - ppublish SO - Endocr Pract. 2026 Sep;32(9):1422-1429. doi: 10.1016/j.eprac.2026.04.002. Epub 2026 Apr 9. PMID- 41965659 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Apr 11 TI - New growth charts for children and adolescents in Catalonia, Spain: developed from routinely collected data (2013-2019). LID - 10.1186/s12889-026-27263-x [doi] LID - 1650 AB - BACKGROUND: Growth charts are essential for detecting early health conditions in children. This study aims to create up-to-date and region-specific growth charts for children and adolescents using large real-world data from primary care electronic health records (EHR) in Catalonia, Spain. METHODS: We used routinely collected EHR of the Institut Catala de la Salut, the main primary care provider in Catalonia. We included children aged one month to 14 years with a birthweight greater than 2500 gr, and at least one anthropometric measurement registered (2013-2019). Growth references for head circumference, weight, length/height, and body mass index (BMI) were fitted using GAMLSS models. We built our charts with data recorded in 2013, validated them using data from 2014 to 2019 and compared them to WHO and Spanish growth charts. RESULTS: With a total of 876,097 records from 155,950 children, we estimated new growth charts. Our curves were higher in the highest percentile, especially for weight and BMI (starting from 4 years old), compared to the WHO standards and for extreme percentiles compared to outdated national charts but were similar to more recent national curves. Validation analyses showed similar results with differences only seen for extreme weight and BMI percentile curves, older ages and later years. CONCLUSIONS: We created new growth charts using a novel approach, accurately representing local growth patterns in the population living in Catalonia. These charts offer primary care professionals a valuable tool for assessing children's and adolescents' growth in the region. CI - (c) 2026. The Author(s). FAU - Mora, Nuria AU - Mora N AD - Primary Care Services Information System (SISAP), Institut Catala de la Salut (ICS), Gran Via de les Corts Catalanes 587, Barcelona, Spain. FAU - Palomar-Cros, Anna AU - Palomar-Cros A AD - Fundacio Institut Universitari per a la recerca a l'Atencio Primaria de Salut Jordi Gol i Gurina (IDIAPJGol), Gran Via de les Corts Catalanes 587, Barcelona, Spain. FAU - Perez-Crespo, Laura AU - Perez-Crespo L AD - Fundacio Institut Universitari per a la recerca a l'Atencio Primaria de Salut Jordi Gol i Gurina (IDIAPJGol), Gran Via de les Corts Catalanes 587, Barcelona, Spain. FAU - Mendez-Boo, Leonardo AU - Mendez-Boo L AD - Primary Care Services Information System (SISAP), Institut Catala de la Salut (ICS), Gran Via de les Corts Catalanes 587, Barcelona, Spain. FAU - Ramos, Francisca AU - Ramos F AD - Primary Care Services Information System (SISAP), Institut Catala de la Salut (ICS), Gran Via de les Corts Catalanes 587, Barcelona, Spain. FAU - Quintana, Manuel AU - Quintana M AD - Primary Care Services Information System (SISAP), Institut Catala de la Salut (ICS), Gran Via de les Corts Catalanes 587, Barcelona, Spain. FAU - Rene, Anna AU - Rene A AD - Primary Care Services Information System (SISAP), Institut Catala de la Salut (ICS), Gran Via de les Corts Catalanes 587, Barcelona, Spain. FAU - Fina, Francesc AU - Fina F AD - Primary Care Services Information System (SISAP), Institut Catala de la Salut (ICS), Gran Via de les Corts Catalanes 587, Barcelona, Spain. FAU - Coma, Ermengol AU - Coma E AD - Primary Care Services Information System (SISAP), Institut Catala de la Salut (ICS), Gran Via de les Corts Catalanes 587, Barcelona, Spain. ecomaredon@gencat.cat. FAU - Duarte-Salles, Talita AU - Duarte-Salles T AD - Fundacio Institut Universitari per a la recerca a l'Atencio Primaria de Salut Jordi Gol i Gurina (IDIAPJGol), Gran Via de les Corts Catalanes 587, Barcelona, Spain. AD - Department of Medical Informatics, Erasmus University Medical Center, Dr. Molewaterplein 40, Rotterdam, The Netherlands. LA - eng PT - Journal Article DEP - 20260411 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Spain MH - *Growth Charts MH - Child, Preschool MH - Child MH - Electronic Health Records MH - Infant MH - Adolescent MH - Female MH - Male MH - Primary Health Care MH - Body Height MH - Body Mass Index MH - Reference Values PMC - PMC13195899 OTO - NOTNLM OT - Childhood OT - Electronic health records OT - Growth curves OT - Primary care COIS- Declarations. Ethics approval and consent to participate: All analysis and methods of this study have been performed in accordance with the Declaration of Helsinki (last update, Fortaleza, Brazil 2013) and existing relevant guidelines and regulations in Spain. This work was approved by the Clinical Research Ethics Committee of IDIAP Jordi Gol with reference number 23/091-P, including a waiver for the informed consent of patients taking part in the study, and the data extracted from the EHR were fully anonymised. There was no patient or public involvement in this study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/12 04:37 MHDA- 2026/05/22 06:36 PMCR- 2026/04/11 CRDT- 2026/04/11 23:17 PHST- 2024/09/12 00:00 [received] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/05/22 06:36 [medline] PHST- 2026/04/12 04:37 [pubmed] PHST- 2026/04/11 23:17 [entrez] PHST- 2026/04/11 00:00 [pmc-release] AID - 10.1186/s12889-026-27263-x [pii] AID - 27263 [pii] AID - 10.1186/s12889-026-27263-x [doi] PST - epublish SO - BMC Public Health. 2026 Apr 11;26(1):1650. doi: 10.1186/s12889-026-27263-x. PMID- 41963909 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1476-511X (Electronic) IS - 1476-511X (Linking) VI - 25 IP - 1 DP - 2026 Apr 10 TI - Assessment of BMI percentages of obesity thresholds and cardiometabolic risk factors in children and adolescents: a retrospective cross-sectional study in Beijing. LID - 10.1186/s12944-026-02940-3 [doi] LID - 133 AB - BACKGROUND: The prevalence of pediatric obesity, particularly severe obesity, is rising rapidly in China. Few studies have examined the relationship between body mass index (BMI) expressed as percentages of obesity thresholds (%BMI) and cardiometabolic risks in Chinese pediatric population. This study aims to evaluate the dose-response relationship between %BMI and cardiometabolic risk factors among children and adolescents in Beijing. METHODS: This retrospective cross-sectional study utilized electronic health records (EHRs) of children and adolescents aged 7-18 years with obesity attending a specialized clinic. Anthropometric and laboratory data were extracted and validated. Individuals were categorized into class 1 obesity (BMI 100-120% of the obesity thresholds), class 2 (120-140%), and class 3 (>/= 140%). Logistic regression assessed the associations between obesity subcategories and four cardiometabolic risk factors, including prediabetes, dyslipidemia, insulin resistance (IR), and elevated liver enzymes. Restricted cubic spline (RCS) models were used to investigate the dose-response relationship between %BMI and cardiometabolic risk factors. RESULTS: Among 1,761 included individuals, class 3 obesity was associated with significantly higher odds of prediabetes (OR = 1.49 [95% CI: 1.01-2.19] for boys; OR = 2.91 [95% CI: 1.57-5.41] for girls), IR (OR = 4.40 [95% CI: 2.66-7.51] for boys; OR = 3.52 [95% CI: 1.63-8.35] for girls), and elevated liver enzymes (OR = 2.65 [95% CI: 1.81-3.93] for boys; OR = 2.97 [95% CI: 1.65-5.47] for girls) compared to class 1. Linear dose-response relationships were observed between %BMI and these factors. Dyslipidemia and its components (e.g., low high-density lipoprotein cholesterol and high triglyceride) exhibited complex dose-response relationships that varied by sex and Tanner Stage. CONCLUSIONS: Among obese children and adolescents in Beijing, higher %BMI might be linearly associated with greater likelihood of prediabetes, IR, and elevated liver enzymes, while dyslipidemia exhibits sex- and puberty-specific patterns. Further researches are required to characterize cardiometabolic risks across the obesity spectrum in Chinese pediatric population to inform targeted interventions. FAU - Xiao, Ling AU - Xiao L AD - Clinical Nutrition Center, Capital Center for Children's Health, Capital Medical University, Beijing, 100020, China. FAU - Zeng, Yin AU - Zeng Y AD - Institute of Medical Information/Medical Library, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100020, China. FAU - Zheng, Si AU - Zheng S AD - Institute of Medical Information/Medical Library, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100020, China. FAU - Wang, Xiao-Yan AU - Wang XY AD - Clinical Nutrition Center, Capital Center for Children's Health, Capital Medical University, Beijing, 100020, China. FAU - Guo, Zhen AU - Guo Z AD - Institute of Medical Information/Medical Library, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100020, China. FAU - Cui, Ying AU - Cui Y AD - Capital Center for Children's Health, Capital Medical University, Beijing, 100020, China. FAU - Tang, Rui AU - Tang R AD - Institute of Medical Information/Medical Library, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100020, China. FAU - Guo, Lin-Lin AU - Guo LL AD - Capital Center for Children's Health, Capital Medical University, Beijing, 100020, China. guolinlin@shouer.com.cn. FAU - Li, Jiao AU - Li J AD - Institute of Medical Information/Medical Library, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100020, China. jiao.li@pumc.edu.cn. LA - eng GR - 2023ZD0509701/National Science and Technology Major Project/ GR - 2024YFA1307701/Key Technologies Research and Development Program/ GR - 2021-I2M-1-056/CAMS Innovation Fund for Medical Sciences/ PT - Journal Article DEP - 20260410 PL - England TA - Lipids Health Dis JT - Lipids in health and disease JID - 101147696 SB - IM MH - Humans MH - Child MH - Adolescent MH - Male MH - Female MH - Cross-Sectional Studies MH - Retrospective Studies MH - *Body Mass Index MH - *Cardiometabolic Risk Factors MH - Insulin Resistance MH - *Dyslipidemias/epidemiology/blood MH - Beijing/epidemiology MH - Risk Factors MH - *Prediabetic State/epidemiology/blood MH - *Obesity/epidemiology MH - *Pediatric Obesity/epidemiology/complications/blood MH - *Cardiovascular Diseases/epidemiology PMC - PMC13188306 OTO - NOTNLM OT - Cardiometabolic risk OT - Dyslipidemia OT - Insulin resistance OT - Pediatric OT - Prediabetes OT - Severe obesity COIS- Declarations. Ethics approval and consent to participate: The study is conducted in accordance with the principles outlined in the Declaration of Helsinki. Given the retrospective nature of this study and the anonymous status of the data, the need for written informed consent was waived by the ethics committee of Capital Center for Children's Health, Capital Medical University (No. SHERLLM2024044). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/11 00:32 MHDA- 2026/06/27 12:36 PMCR- 2026/04/10 CRDT- 2026/04/10 23:50 PHST- 2026/01/22 00:00 [received] PHST- 2026/03/28 00:00 [accepted] PHST- 2026/06/27 12:36 [medline] PHST- 2026/04/11 00:32 [pubmed] PHST- 2026/04/10 23:50 [entrez] PHST- 2026/04/10 00:00 [pmc-release] AID - 10.1186/s12944-026-02940-3 [pii] AID - 2940 [pii] AID - 10.1186/s12944-026-02940-3 [doi] PST - epublish SO - Lipids Health Dis. 2026 Apr 10;25(1):133. doi: 10.1186/s12944-026-02940-3. PMID- 41963694 OWN - NLM STAT- MEDLINE DCOM- 20260821 LR - 20261008 IS - 1179-1942 (Electronic) IS - 0114-5916 (Linking) VI - 49 IP - 9 DP - 2026 Sep TI - Reliability of Self-Reported Maternal Health and Mother-Infant Outcome Data in Web-Based Questionnaires. PG - 1069-1084 LID - 10.1007/s40264-026-01671-9 [doi] AB - OBJECTIVES: The BELpREG registry in Belgium collects self-reported real-world data on perinatal medication use and mother-infant outcomes. Given the importance of self-reported data for pregnancy safety studies, this study aims to assess the reliability of maternal health and mother-infant outcome data reported in BELpREG. METHODS: We compared self-reported maternal health and mother-infant outcomes in the BELpREG registry with medical record data from gynaecologists, general practitioners, and midwives. Participants included pregnant women enrolled in BELpREG, aged 18 years or older, who delivered between November 2022 and April 2024 and had medical record data provided by at least one healthcare professional (HCP). Comparisons for continuous variables such as pre-pregnancy body mass index (BMI), gestational age at delivery, and infant metrics at birth were analysed using intraclass correlation coefficients (ICCs). For dichotomous and categorical variables, including pregnancy complications, delivery characteristics, and hospital admissions, we used Cohen's Kappa and observed proportions of positive and negative agreement. RESULTS: This study included 175 participants with available medical record data. Medical records were mostly returned by gynaecologists (40%) and midwives (25.7%). Reliability was high for pregnancy complications, onset, and mode of delivery. Gestational age showed almost perfect concordance (ICC 0.99). Infant outcomes, including birth metrics and Apgar scores, were highly reliable (ICC > 0.90), with almost perfect categorisation into birth weight percentiles (Cohen's Kappa 0.97). Self-reported maternal BMI exhibited moderate reliability as a continuous measure (ICC 0.75), but almost perfect agreement when categorised (Cohen's Kappa 0.89). The low prevalence of hospital admissions, delivery complications, infant complications, postpartum complications, and birth defects limited the assessment of these outcomes. CONCLUSIONS: The BELpREG registry demonstrated high agreement between self-reported and HCP-reported data for most maternal health and mother-infant outcomes, supporting its use in future pregnancy safety studies. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature Switzerland AG. FAU - Sillis, Laure AU - Sillis L AUID- ORCID: 0000-0002-7545-2357 AD - Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium. laure.sillis@kuleuven.be. AD - Research Foundation Flanders (FWO), Brussels, Belgium. laure.sillis@kuleuven.be. AD - L-C&Y-KU Leuven Child and Youth Institute, Leuven, Belgium. laure.sillis@kuleuven.be. FAU - Van Mechelen, Laura AU - Van Mechelen L AD - Faculty of Pharmaceutical Sciences, KU Leuven, Leuven, Belgium. FAU - van Gelder, Marleen M H J AU - van Gelder MMHJ AUID- ORCID: 0000-0003-4853-4434 AD - IQ Health Science Department, Radboud University Medical Centre, Nijmegen, The Netherlands. FAU - Lenie, Sien AU - Lenie S AUID- ORCID: 0009-0000-8786-4765 AD - Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium. AD - L-C&Y-KU Leuven Child and Youth Institute, Leuven, Belgium. FAU - Allegaert, Karel AU - Allegaert K AUID- ORCID: 0000-0001-9921-5105 AD - Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium. AD - L-C&Y-KU Leuven Child and Youth Institute, Leuven, Belgium. AD - Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - Department of Clinical Pharmacy, Erasmus MC Sophia's Children Hospital, Rotterdam, The Netherlands. FAU - Bogaerts, Annick AU - Bogaerts A AUID- ORCID: 0000-0003-2718-4682 AD - L-C&Y-KU Leuven Child and Youth Institute, Leuven, Belgium. AD - Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - Faculty of Health, University of Plymouth, Devon, UK. FAU - De Vos, Maarten AU - De Vos M AUID- ORCID: 0000-0002-3482-5145 AD - Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - Department of Electrical Engineering (ESAT), KU Leuven, Leuven, Belgium. FAU - Hompes, Titia AU - Hompes T AUID- ORCID: 0000-0002-6206-0389 AD - Adult Psychiatry UPC, KU Leuven, Leuven, Belgium. AD - Department of Neurosciences, KU Leuven, Leuven, Belgium. FAU - Smits, Anne AU - Smits A AUID- ORCID: 0000-0002-0710-6698 AD - L-C&Y-KU Leuven Child and Youth Institute, Leuven, Belgium. AD - Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium. FAU - Van Calsteren, Kristel AU - Van Calsteren K AUID- ORCID: 0000-0002-2438-6783 AD - Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium. FAU - Verbakel, Jan Y AU - Verbakel JY AUID- ORCID: 0000-0002-7166-7211 AD - Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium. AD - Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK. FAU - Foulon, Veerle AU - Foulon V AUID- ORCID: 0000-0002-4053-3915 AD - Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium. AD - L-C&Y-KU Leuven Child and Youth Institute, Leuven, Belgium. FAU - Ceulemans, Michael AU - Ceulemans M AUID- ORCID: 0000-0002-4130-5869 AD - Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium. AD - Research Foundation Flanders (FWO), Brussels, Belgium. AD - L-C&Y-KU Leuven Child and Youth Institute, Leuven, Belgium. AD - IQ Health Science Department, Radboud University Medical Centre, Nijmegen, The Netherlands. LA - eng PT - Journal Article DEP - 20260410 PL - New Zealand TA - Drug Saf JT - Drug safety JID - 9002928 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Self Report/standards MH - Adult MH - Reproducibility of Results MH - *Pregnancy Outcome/epidemiology MH - Belgium/epidemiology MH - *Maternal Health/statistics & numerical data MH - Registries MH - Surveys and Questionnaires MH - Infant, Newborn MH - Pregnancy Complications/epidemiology MH - Internet MH - Young Adult MH - Gestational Age MH - Medical Records COIS- Declarations. Author contributions: Laure Sillis: Conceptualisation, data curation, formal analysis, funding acquisition, investigation, methodology, project administration, software, validation, visualisation, and writing - original draft. Laura Van Mechelen: Formal analysis, investigation, methodology, project administration, and writing - review and editing. Marleen M.H.J. van Gelder: Conceptualisation, methodology, and writing - review and editing. Sien Lenie: Investigation, project administration, validation, and writing - review and editing. Karel Allegaert: Methodology and writing - review and editing. Annick Bogaerts: Methodology and writing - review and editing. Maarten De Vos: Methodology and writing - review and editing. Titia Hompes: Methodology and writing - review and editing. Anne Smits: Methodology and writing - review and editing. Kristel Van Calsteren: Methodology and writing - review and editing. Jan Y Verbakel: Methodology and writing - review and editing. Veerle Foulon: Conceptualisation, funding acquisition, methodology, project administration, resources, supervision, and writing - review and editing. Michael Ceulemans: Conceptualisation, funding acquisition, investigation, methodology, project administration, resources, supervision, and writing - review and editing. All authors read and approved the final version. Conflict of interest: The authors declare no conflicts of interest. The companies providing research grants for the BELpREG initiative had no role in the design of BELpREG or this reliability study; nor in the collection, analysis, or interpretation of data; the writing of the manuscript; or the decision to publish the results. Data sharing: The data used for this analysis were collected under participants' informed consent for uses as directed by the study principal investigator and are not available for public access due to ethical and privacy reasons. Requests for use of the data should be directed to the corresponding author. Code availability: Statistical analyses were performed using R software. Requests for use of the code should be directed to the corresponding author. Ethics approval: Ethics approval for this study was obtained from the Ethics Committee Research UZ/KU Leuven (S66464). Consent to participate: All BELpREG participants provided electronic informed consent. Consent for publication: Not applicable. No individual participant data are presented in this article in a way that would allow identification of individual participants. Additional Contributions: The authors express their gratitude to the BELpREG participants and healthcare professionals who provided data for this study. Special thanks to Linda Lukeba for her pivotal role in data collection from healthcare professionals. The authors also appreciate the technical support from Digile for the BELpREG registry and the assistance from Medipim in upgrading the BELpREG questionnaires. Disclaimer: The terms 'individuals', 'participants', 'women', 'woman', 'mother', and 'maternal' are used in this article to refer to all those who are pregnant and give birth. The authors acknowledge that not all people who are pregnant and give birth will identify themselves as women. EDAT- 2026/04/11 00:32 MHDA- 2026/08/21 17:37 CRDT- 2026/04/10 23:29 PHST- 2025/04/08 00:00 [received] PHST- 2026/03/18 00:00 [accepted] PHST- 2026/08/21 17:37 [medline] PHST- 2026/04/11 00:32 [pubmed] PHST- 2026/04/10 23:29 [entrez] AID - 10.1007/s40264-026-01671-9 [pii] AID - 10.1007/s40264-026-01671-9 [doi] PST - ppublish SO - Drug Saf. 2026 Sep;49(9):1069-1084. doi: 10.1007/s40264-026-01671-9. Epub 2026 Apr 10. PMID- 41961782 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260410 LR - 20260813 IS - 2767-3375 (Electronic) IS - 2767-3375 (Linking) VI - 6 IP - 4 DP - 2026 TI - Predicting the burden of acute malnutrition in drought-prone regions of Kenya: A statistical analysis. PG - e0004485 LID - 10.1371/journal.pgph.0004485 [doi] LID - e0004485 AB - In drought-prone regions, timely and granular predictions of the burden of acute malnutrition could support decision-making. We explored whether routinely collected and/or publicly available data could be used to predict the prevalence of global and severe acute malnutrition, as well as the mean weight-for-height Z-score and middle-upper-arm circumference for age Z-score, in arid- and semi-arid regions of Kenya, where drought is projected to increase in frequency and intensity. The study covered six counties of northern Kenya and the period 2015-2019, during which a major drought occurred. To validate models, we sourced and curated so-called SMART anthropometric surveys covering one or more sub-counties for a total of 79 explicit survey strata and 44,218 individual child observations. We associated these surveys' predictors specified at the sub-county or county level, and comprising climate food security, observed malnutrition, epidemic disease incidence, health service utilisation and other social conditions. We explored both generalised linear or additive models and random forests and quantified their out-of-sample performance using cross-validation. In most counties, survey-estimated nutritional indicators were worst during the October 2016-December 2019 drought period; the drought also saw peaks in insecurity and steep vaccination declines. Candidate models had moderate performance, with random forests slightly outperforming generalised linear models. The most promising performance was observed for global acute malnutrition prevalence. The study did not identify a model that could very accurately predict malnutrition burden, but analyses relying on larger datasets with a wider range of predictors and encompassing multiple drought periods may yield sufficient performance and are warranted given the potential utility and efficiency of predictive models in lieu of assumptions or expensive and untimely ground data collection. CI - Copyright: (c) 2026 Checchi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Checchi, Francesco AU - Checchi F AUID- ORCID: 0000-0001-9030-5382 AD - Department of Infectious Disease Epidemiology and International Health, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom. FAU - AbuKoura, Rahaf AU - AbuKoura R AUID- ORCID: 0000-0002-1956-2551 AD - Department of Infectious Disease Epidemiology and International Health, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom. FAU - Kadiyala, Suneetha AU - Kadiyala S AD - Department of Population Health, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom. FAU - Nyawo, Mara AU - Nyawo M AUID- ORCID: 0000-0001-8011-9914 AD - United Nations Children's Fund, East and Southern Africa Regional Office, Nairobi, Kenya. FAU - Maina, Lucy AU - Maina L AD - United Nations Children's Fund, Kenya Country Office, Nairobi, Kenya. LA - eng PT - Journal Article DEP - 20260410 PL - United States TA - PLOS Glob Public Health JT - PLOS global public health JID - 9918283779606676 PMC - PMC13068232 COIS- The authors have declared that no competing interests exist. EDAT- 2026/04/10 18:32 MHDA- 2026/04/10 18:33 PMCR- 2026/04/10 CRDT- 2026/04/10 13:33 PHST- 2025/03/21 00:00 [received] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/04/10 18:33 [medline] PHST- 2026/04/10 18:32 [pubmed] PHST- 2026/04/10 13:33 [entrez] PHST- 2026/04/10 00:00 [pmc-release] AID - PGPH-D-25-00663 [pii] AID - 10.1371/journal.pgph.0004485 [doi] PST - epublish SO - PLOS Glob Public Health. 2026 Apr 10;6(4):e0004485. doi: 10.1371/journal.pgph.0004485. eCollection 2026. PMID- 41961131 OWN - NLM STAT- Publisher LR - 20260625 IS - 1432-0932 (Electronic) IS - 0940-6719 (Linking) DP - 2026 Apr 10 TI - Finding normo: reporting values for the SRS22r score in healthy sport-active children. LID - 10.1007/s00586-026-09929-7 [doi] AB - INTRODUCTION: Scoliosis Research Society-22 revised (SRS-22r) is a disease-specific measure of quality of life in patients diagnosed with idiopathic scoliosis (AIS). When answering the SRS-22r, patients answer 22 questions with scores 1-5, 1 corresponding to the worst possible option, and 5 to the best. It is validated in children with scoliosis > 10 years. Low SRS-22r scores have been suggested to serve as an indicator for considering surgical intervention along with a progression in Cobb angle. However, there are only few studies on SRS-22r scores among children without spine conditions, making the impact of a spine condition on the health-related quality of life scores in adolescents and teenagers difficult to assess. Since surgical treatment of progressive curves is often performed before age 16, normative data for this age group are essential. The aim therefore was to estimate normative data on children under 16 years of age and to assess what influenced the scores in otherwise healthy children without AIS. METHOD: In total, 264 children, attending a sports-focused public school, were invited to answer the SRS-22r questionnaire and self-reported Tanner stage. 110 children (70 girls) answered the questionnaire, all but one reporting tanner stage as well. All students who received the questionnaire underwent a spine examination performed by a physiotherapist student. RESULTS: The participants had a median age of 12 years [Interquartile range (IQR): 11;14]; most were reporting Tanner stages 3 or 4, although 27.5% of the boys reported stage 5. The median scores of mental health and self-image were 4.0 [IQR: 3.6; 4.4] and 4.2 [IQR: 3.8; 4.4], with boys reporting higher scores in both domains compared to girls. Among all children, the median pain reported was 4.2 [IQR: 3.8;4.6] with no sex difference. The differences between the genders were assessed using the Mann-Whitney U test. Ordinal logistic regression showed that lower pain levels and male sex predicted better mental health and self-image, while higher Tanner stages correlated with poorer outcomes. Interestingly, three boys aged 11 reported Tanner Stage 5, highlighting potential inaccuracies in self-reported data and the need for assisted reporting in body composition questionnaires. CONCLUSION: This study highlights the importance of normative data, revealing that active children without scoliosis report pain and issues with mental health and self-image, when addressed with the SRS-22r. In particular, the SRS-22r scores in this cohort were lower than those found in previous studies of children with scoliosis, highlighting the challenges of interpreting and potentially using the SRS-22r results in a clinical setting. FAU - Damsgaard Hojsager, Frederik AU - Damsgaard Hojsager F AD - Department of Orthopaedic Surgery, Lillebaelt Hospital, Kolding, Denmark. frederik.hojsager@rsyd.dk. FAU - Wedderkopp, Niels AU - Wedderkopp N AD - Clinical Institute, University of Southern Denmark, Odense, Denmark. FAU - Borch, Luise AU - Borch L AD - Department of Pediatric and Adolescent medicine, Godstrup Hospital, Herning, Denmark. AD - NIDO, Godstrup Hospital, Herning, Denmark. FAU - Castelein, Rene AU - Castelein R AD - Department of Orthopedics, University Medical Center Utrecht, Utrecht, Netherlands. FAU - Simony, Ane AU - Simony A AD - Department of Orthopaedic Surgery, Lillebaelt Hospital, Kolding, Denmark. AD - Department of Regional Health Research, University of Southern Denmark, Odense, Denmark. LA - eng PT - Journal Article DEP - 20260410 PL - Germany TA - Eur Spine J JT - European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society JID - 9301980 SB - IM OTO - NOTNLM OT - Back healthy population OT - Cohort specific data OT - Danish public school data OT - Mental health OT - SRS22r COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/04/10 13:00 MHDA- 2026/04/10 13:00 CRDT- 2026/04/10 11:04 PHST- 2025/09/24 00:00 [received] PHST- 2026/04/01 00:00 [accepted] PHST- 2026/03/19 00:00 [revised] PHST- 2026/04/10 13:00 [medline] PHST- 2026/04/10 13:00 [pubmed] PHST- 2026/04/10 11:04 [entrez] AID - 10.1007/s00586-026-09929-7 [pii] AID - 10.1007/s00586-026-09929-7 [doi] PST - aheadofprint SO - Eur Spine J. 2026 Apr 10. doi: 10.1007/s00586-026-09929-7. PMID- 41959702 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260410 LR - 20260813 IS - 2215-0161 (Print) IS - 2215-0161 (Electronic) IS - 2215-0161 (Linking) VI - 16 DP - 2026 Jun TI - Effectiveness of a structured physiotherapy intervention on psychomotor and quality of life in children with autism spectrum disorder: A randomised controlled trial protocol. PG - 103873 LID - 10.1016/j.mex.2026.103873 [doi] LID - 103873 AB - Children with Autism Spectrum Disorder (ASD) frequently experience psychomotor impairments, limited participation in physical activities, and reduced quality of life (QoL). Exercise shows promising benefits, but physiotherapy approaches in ASD are underreported, with limited evidence supporting a structured framework that systematically targets motor and functional outcomes. This study protocol describes a single-blinded randomised controlled trial evaluating the effectiveness of a structured physiotherapy intervention on motor skills, physical activity levels, and behavioural and QoL among children with mild to moderate ASD. This trial will include 64 children aged 6-10 years with ASD. Participants will be randomly assigned to an intervention group or a control group. Both groups will receive usual care therapy, equated between groups. The intervention group will also receive structured physiotherapy twice weekly for 12 weeks, each session lasting 60 min. The intervention integrates coordination, balance, strength, and endurance training. Outcome assessments will be conducted at baseline and post-intervention using validated instruments: GARS-3, BOT-2, GLTEQ, CBCL and PedsQL. Data analysis will follow the intention-to-treat principle and will examine between-group and within-group changes across all outcome measures. Qualitative data will be analysed using thematic analysis to characterise themes reflecting participants' engagement and parents' and caregivers' perspectives on the intervention. CI - (c) 2026 The Authors. FAU - Alwi, Nazurah AU - Alwi N AD - Physiotherapy Programme, Centre for Rehabilitation and Special Needs Studies, Faculty of Health Science, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia. FAU - Zanudin, Asfarina AU - Zanudin A AD - Physiotherapy Programme, Centre for Rehabilitation and Special Needs Studies, Faculty of Health Science, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia. FAU - Ahmad, Mahadir AU - Ahmad M AD - Clinical Psychology Programme, Centre for Community Health Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia. FAU - Mohamad, Nor Azizah AU - Mohamad NA AD - Physiotherapy Unit, Department of Rehabilitation, UKM Specialist Children's Hospital, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia. LA - eng PT - Journal Article DEP - 20260318 PL - Netherlands TA - MethodsX JT - MethodsX JID - 101639829 PMC - PMC13059026 OTO - NOTNLM OT - Autism spectrum disorder OT - Motor-based intervention OT - Physiotherapy OT - Psychomotor OT - Quality of life COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/10 06:32 MHDA- 2026/04/10 06:33 PMCR- 2026/03/18 CRDT- 2026/04/10 05:36 PHST- 2025/11/30 00:00 [received] PHST- 2026/03/17 00:00 [accepted] PHST- 2026/04/10 06:33 [medline] PHST- 2026/04/10 06:32 [pubmed] PHST- 2026/04/10 05:36 [entrez] PHST- 2026/03/18 00:00 [pmc-release] AID - S2215-0161(26)00091-9 [pii] AID - 103873 [pii] AID - 10.1016/j.mex.2026.103873 [doi] PST - epublish SO - MethodsX. 2026 Mar 18;16:103873. doi: 10.1016/j.mex.2026.103873. eCollection 2026 Jun. PMID- 41957688 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20261016 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2026 Apr 10 TI - Association between dietary self-perception and sugar-sweetened beverage consumption among young adult Latinas. PG - e102 LID - 10.1017/S1368980026102523 [doi] LID - e102 AB - OBJECTIVE: To investigate the relationship between self-perceived overall dietary healthfulness and self-reported sugar-sweetened beverage (SSB) consumption among young adult Latinas, accounting for socio-economic and acculturation-related factors. DESIGN: Cross-sectional analysis using survey data. SSB intake was assessed using the BEVQ-15, and dietary self-perception was measured via a two-item scale. Multiple linear regression models examined associations between self-perception and total daily SSB intake, adjusting for income, education and two validated acculturation indicators. SETTING: Participants were recruited from a national online panel across the USA. PARTICIPANTS: A total of 881 Latina women aged 18-29 years participated. After removing cases with invalid outcome responses and outliers, 840 and 829 were included in descriptive and regression analyses. RESULTS: Better dietary self-perception was significantly associated with greater total SSB intake in both unadjusted (B = 1.74, P = 0.048) and fully adjusted models (B = 2.10, P = 0.017). Lower income (B = -0.64, P = 0.031) and lower education (B = -0.77, P = 0.026) were also associated with higher intake. Acculturation variables were NS. Subcategory models showed positive associations between self-perception and sweet tea (B = 0.99, P < 0.001) and black coffee/tea with sugar (B = 0.51, P < 0.01) and a marginal inverse association with soft drinks (B = -0.47, P = 0.060). CONCLUSIONS: Young Latinas who perceive their diets as healthy may consume more added sugar from beverages than recommended. Public health efforts should address this perception gap and emphasise culturally relevant messaging about hidden sugars in commonly consumed drinks. FAU - Zhou, Mi AU - Zhou M AUID- ORCID: 0000-0001-8822-4188 AD - Department of Nutrition, Food Science, and Packaging, https://ror.org/04qyvz380San Jose State University, USA. FAU - Ramirez, A Susana AU - Ramirez AS AD - Department of Public Health, University of California Merced, USA. FAU - Xu, Xinyu AU - Xu X AD - Department of Nutrition, Food Science, and Packaging, https://ror.org/04qyvz380San Jose State University, USA. FAU - Bergman, Jacqueline AU - Bergman J AD - Department of Nutrition, Food Science, and Packaging, https://ror.org/04qyvz380San Jose State University, USA. LA - eng GR - P30 DK092924/DK/NIDDK NIH HHS/United States GR - R01DK116852/NH/NIH HHS/United States GR - P30DK092924/DK/NIDDK NIH HHS/United States GR - K01CA190659/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20260410 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Young Adult MH - Acculturation MH - Cross-Sectional Studies MH - *Diet/ethnology/psychology MH - Feeding Behavior/ethnology/psychology MH - *Hispanic or Latino/psychology/statistics & numerical data MH - *Self Concept MH - Socioeconomic Factors MH - *Sugar-Sweetened Beverages/statistics & numerical data MH - United States PMC - PMC13434627 OTO - NOTNLM OT - Acculturation OT - Beverage consumption OT - Dietary behaviours OT - Dietary self-perception OT - Latinas OT - Sugar-sweetened beverages COIS- There are no conflicts of interest. EDAT- 2026/04/10 06:33 MHDA- 2026/05/07 06:38 PMCR- 2026/04/10 CRDT- 2026/04/10 00:02 PHST- 2026/05/07 06:38 [medline] PHST- 2026/04/10 06:33 [pubmed] PHST- 2026/04/10 00:02 [entrez] PHST- 2026/04/10 00:00 [pmc-release] AID - S1368980026102523 [pii] AID - 10.1017/S1368980026102523 [doi] PST - epublish SO - Public Health Nutr. 2026 Apr 10;29(1):e102. doi: 10.1017/S1368980026102523. PMID- 41957451 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Apr 9 TI - The role of habit strength in the theory of planned behavior for fruit and vegetable intake among women in Saudi Arabia. LID - 10.1038/s41598-026-47394-w [doi] LID - 16763 AB - Low fruit and vegetable (F&V) consumption is prevalent among Saudi women, despite global health recommendations. To identify the psychological determinants of F&V intake using the theory of planned behavior (TPB) and to examine the moderating role of habit. A cross-sectional survey was conducted among 467 adult Saudi women. The questionnaire measured TPB constructs-attitude, subjective norm (SN), perceived behavioral control (PBC), intention, and behavior-alongside habit strength using a validated self-report habit index. Structural equation modeling (SEM) tested the TPB model, and multi-group analysis examined differences across low, medium, and high habit levels. Only 22.3% of women met the WHO recommendation of >/= 5 F&V servings daily, with significant variation by habit level (10.2% low-habit vs. 30.5% high-habit; p < 0.001). The high habit group showed significantly better knowledge of WHO recommendations (p = 0.013), healthier dietary perceptions (p < 0.001), and more frequent purchasing and preparation of F&V (p < 0.001). Physical activity also increased with habit strength (p < 0.001). Compared to the low-habit group, women in the high-habit group reported higher scores for all the TPB constructs (p < 0.001). SEM results indicated that the TPB model explained 31% of the variance in behavior and 75% in intention. In the overall sample, both intention (beta = 0.32, p = 0.005) and PBC (beta = 0.26, p = 0.032) predicted F&V intake. PBC was the strongest predictor of intention (beta = 0.66, p < 0.001), followed by SN and attitude. Across habit levels, PBC consistently predicted intention; attitude was significant in the low-habit group, and SN in the high-habit group. Perceived control strongly influences both intention and behavior, but habit moderates these relationships. Interventions should enhance self-efficacy and establish regular F&V consumption among Saudi women. CI - (c) 2026. The Author(s). FAU - Alshaalan, Rasha AU - Alshaalan R AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, 11671, Riyadh, Saudi Arabia. FAU - Alhassani, Walaa Essam AU - Alhassani WE AD - Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, P.O. Box 715, 21955, Makkah, Saudi Arabia. FAU - Alasmari, Sarah A AU - Alasmari SA AD - Public Health Department, College of Health Sciences, Saudi Electronic University, Riyadh, Saudi Arabia. FAU - Allily, Rowida Khader AU - Allily RK AD - Food and Nutrition Department, Human Sciences and Design Faculty, King Abdulaziz University, Jeddah, 22258, Saudi Arabia. FAU - Alharbi, Nouf Abdullah AU - Alharbi NA AD - Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, P.O. Box 6666, 51452, Buraydah, Saudi Arabia. FAU - Wazzan, Huda AU - Wazzan H AD - Food and Nutrition Department, Human Sciences and Design Faculty, King Abdulaziz University, Jeddah, 22258, Saudi Arabia. FAU - Jalloun, Rola Adnan AU - Jalloun RA AD - Department of Clinical Nutrition, College of Applied Medical Sciences, Taibah University, Universities Road, P.O. Box 344, Medina, Saudi Arabia. FAU - Jan, Majd AU - Jan M AD - Department of Clinical Pharmacy and Pharmacology, Ibn Sina National College for Medical Studies, Jeddah, Saudi Arabia. FAU - Hanbazaza, Mahitab A AU - Hanbazaza MA AD - Food and Nutrition Department, Human Sciences and Design Faculty, King Abdulaziz University, Jeddah, 22258, Saudi Arabia. FAU - Benajiba, Nada AU - Benajiba N AD - Joint Research Unit in Nutrition and Food, RDC-Nutrition AFRA/IAEA, Ibn Tofail University-CNESTEN, 14000, Rabat, Kenitra, Morocco. benajibanada@gmail.com. LA - eng PT - Journal Article DEP - 20260409 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Saudi Arabia MH - Theory of Planned Behavior MH - *Vegetables MH - Adult MH - *Fruit MH - Cross-Sectional Studies MH - *Feeding Behavior/psychology MH - Young Adult MH - Middle Aged MH - Surveys and Questionnaires MH - *Habits MH - Health Behavior MH - Health Knowledge, Attitudes, Practice MH - Adolescent PMC - PMC13223323 OTO - NOTNLM OT - Dietary behavior OT - Fruit and vegetable consumption OT - Habit OT - Saudi women OT - Theory of planned behavior COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical statement: The IRB approval was obtained from the IRB committee at the University before collecting the data from the participants through the online questionnaire. Consent to participate: Every human participant has provided his/her consent to participate in the study. EDAT- 2026/04/10 00:33 MHDA- 2026/06/01 00:33 PMCR- 2026/04/09 CRDT- 2026/04/09 23:38 PHST- 2025/11/04 00:00 [received] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/06/01 00:33 [medline] PHST- 2026/04/10 00:33 [pubmed] PHST- 2026/04/09 23:38 [entrez] PHST- 2026/04/09 00:00 [pmc-release] AID - 10.1038/s41598-026-47394-w [pii] AID - 47394 [pii] AID - 10.1038/s41598-026-47394-w [doi] PST - epublish SO - Sci Rep. 2026 Apr 9;16(1):16763. doi: 10.1038/s41598-026-47394-w. PMID- 41953322 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260409 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Psychometric properties of Rosenberg's self-esteem scale among adolescents: a Rasch model analysis. PG - 1704135 LID - 10.3389/fpsyg.2026.1704135 [doi] LID - 1704135 AB - BACKGROUND: The Rosenberg Self-Esteem Scale (RSES) is one of the most widely used measures of global self-esteem. While its psychometric properties have been extensively studied using classical test theory, limited evidence exists on its performance under modern test theory approaches. AIM: To evaluate the psychometric properties of the RSES using Rasch analysis in a sample of Swedish adolescents. METHODS: A total of 403 adolescents (aged 9-19 years) from six schools completed the RSES. Rasch modelling was applied to assess item fit, person-item targeting, response category functioning, reliability, and differential item functioning (DIF) across sex, age, and BMI. RESULTS: The RSES demonstrated good item fit, with most items aligning with the Rasch model assumptions. The reliability and internal consistency indicators were strong, reflecting the sound psychometric quality of the scale. The person reliability coefficient reached a high value (0.85), with PSI = 2.35, indicating the scale's effective ability to discriminate among individuals across different levels of self-esteem. In addition, item reliability was high (0.99), accompanied by ISI = 8.38, reflecting the precision and stability of item difficulty estimates. Cronbach's alpha was 0.87, with SEM = 2.11, all of which confirm a high level of reliability and internal consistency among the scale items. Regarding targeting, the range of participant abilities was broader than that of item difficulties, with adequate coverage of the central portion of the self-esteem continuum, though some challenges remain in representing extreme levels of the trait. DIF analyses revealed no significant bias across sex, age, or BMI, though several items displayed variation across self-esteem levels. CONCLUSION: The RSES showed acceptable Rasch model fit, structural integrity, and reliability among Swedish adolescents, with no evidence of DIF by sex, age, or BMI. However, suboptimal targeting and misfitting reverse-worded items limited measurement precision, particularly at very low and very high self-esteem levels. Adding items targeting the extremes and revising problematic items could enhance the RSES's utility for adolescent self-esteem assessment in both research and clinical contexts. CI - Copyright (c) 2026 Khalaf, Ziad, Ny and Hammarlund. FAU - Khalaf, Atika AU - Khalaf A AD - The PRO-CARE Group, Faculty of Health Sciences, Kristianstad University, Kristianstad, Sweden. AD - Hind Bint Maktoum College of Nursing and Midwifery, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health, Dubai, United Arab Emirates. FAU - Ziad, Rachid AU - Ziad R AD - Department of Psychology, Echahid Cheikh Larbi Tebessi University, Tebessa, Algeria. FAU - Ny, Pernilla AU - Ny P AD - Department of Health Sciences, Midwifery Research, Reproductive, Perinatal and Sexual Health, Faculty of Medicine, Lund University, Lund, Sweden. FAU - Hammarlund, Catharina Sjodahl AU - Hammarlund CS AD - The PRO-CARE Group, Faculty of Health Sciences, Kristianstad University, Kristianstad, Sweden. AD - Department of Health Sciences, Lund University, Lund, Sweden. LA - eng PT - Journal Article DEP - 20260324 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13055173 OTO - NOTNLM OT - Rasch model analysis OT - Rosenberg's self-esteem scale OT - Sweden OT - adolescents OT - psychometric properties COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/09 06:31 MHDA- 2026/04/09 06:32 PMCR- 2026/03/24 CRDT- 2026/04/09 04:41 PHST- 2025/10/02 00:00 [received] PHST- 2026/02/11 00:00 [revised] PHST- 2026/02/27 00:00 [accepted] PHST- 2026/04/09 06:32 [medline] PHST- 2026/04/09 06:31 [pubmed] PHST- 2026/04/09 04:41 [entrez] PHST- 2026/03/24 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1704135 [doi] PST - epublish SO - Front Psychol. 2026 Mar 24;17:1704135. doi: 10.3389/fpsyg.2026.1704135. eCollection 2026. PMID- 41953185 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260409 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Development and validation of an intraoperative hypothermia risk assessment scale for school-aged children. PG - 1770475 LID - 10.3389/fped.2026.1770475 [doi] LID - 1770475 AB - BACKGROUND: Intraoperative hypothermia (core temperature <36 degrees C) is a common and detrimental complication in pediatric surgery. School-aged children (6-12 years) possess unique physiological vulnerabilities, yet a validated, age-specific risk assessment tool is lacking, leading to potential gaps in targeted prevention. OBJECTIVE: To develop and preliminarily validate a specialized intraoperative hypothermia risk assessment scale for school-aged children undergoing surgery. METHODS: This prospective scale development and validation study had three phases. First, a literature review defined the initial item pool. Second, a two-round Delphi consultation with 16 pediatric surgery experts (authority coefficients: 0.875, 0.900) refined items and confirmed content validity. The Delphi method was chosen for early-phase tool development to achieve clinical face and content validity via expert consensus, with equal item weighting as a starting point for future optimization. Finally, from July to December 2024, the scale was used on 398 school-aged surgical patients at a tertiary children's hospital. Intraoperative nasopharyngeal temperature monitoring was the reference for hypothermia (core temperature <36 degrees C after anesthesia induction). Scale reliability was measured by Cronbach's alpha, and predictive validity was evaluated with ROC curve analysis. RESULTS: The final scale consists of 13 items across two domains: patient-related factors (4 items) and iatrogenic/procedural factors (9 items). Each item is scored 1-3, yielding a total score range of 13-39, with higher scores indicating greater risk. In the validation cohort of 398 patients (211 males, 187 females; mean age 8.4 +/- 2.1 years), the incidence of intraoperative hypothermia was 47.2% (188/398). Baseline characteristics revealed mean BMI 16.8 +/- 3.2 kg/m(2), 62.3% undergoing general anesthesia, and mean surgical duration 2.1 +/- 1.4 h. The scale demonstrated acceptable internal consistency (Cronbach's alpha = 0.731). The ROC analysis revealed an Area Under the Curve (AUC) of 0.743 (95% CI: 0.692-0.794, P < 0.001), indicating fair discriminative ability. The optimal cut-off score was 28, achieving a sensitivity of 0.752 and a specificity of 0.640 for predicting hypothermia. CONCLUSION: We developed a novel, reliable, and valid risk assessment scale for intraoperative hypothermia in school-aged children. This tool enables risk stratification using preoperatively available information to facilitate individualized warming strategies and potentially improve perioperative outcomes. Further multi-center validation is warranted to confirm its generalizability. CI - (c) 2026 Du, Wang, Yang, Liu, Cao, Xia and Yang. FAU - Du, Qingqing AU - Du Q AD - Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. AD - Tongji University School of Medicine, Shanghai, China. FAU - Wang, Zhen AU - Wang Z AD - Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Yang, Lei AU - Yang L AD - Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Liu, Yingmin AU - Liu Y AD - Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Cao, Jing AU - Cao J AD - Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Xia, Mengfan AU - Xia M AD - Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Yang, Xia AU - Yang X AD - Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. LA - eng PT - Journal Article DEP - 20260324 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13055600 OTO - NOTNLM OT - child OT - hypothermia OT - intraoperative complications OT - predictive value OT - risk assessment OT - scale development COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/09 06:32 MHDA- 2026/04/09 06:33 PMCR- 2026/03/24 CRDT- 2026/04/09 04:39 PHST- 2025/12/18 00:00 [received] PHST- 2026/02/18 00:00 [revised] PHST- 2026/02/26 00:00 [accepted] PHST- 2026/04/09 06:33 [medline] PHST- 2026/04/09 06:32 [pubmed] PHST- 2026/04/09 04:39 [entrez] PHST- 2026/03/24 00:00 [pmc-release] AID - 10.3389/fped.2026.1770475 [doi] PST - epublish SO - Front Pediatr. 2026 Mar 24;14:1770475. doi: 10.3389/fped.2026.1770475. eCollection 2026. PMID- 41951412 OWN - NLM STAT- Publisher LR - 20260408 IS - 1349-7235 (Electronic) IS - 0918-2918 (Linking) DP - 2026 Apr 7 TI - A Phase Angle Used as a Screening Tool for Malnutrition in Japanese Patients with Liver Cirrhosis. LID - 10.2169/internalmedicine.6677-25 [doi] AB - Objective Malnutrition and sarcopenia are associated with poor clinical outcomes in patients with cirrhosis. While the Phase angle (PhA) is a promising marker, validated ethnicity-specific cutoff values for Asian populations, who often show different body composition profiles, are lacking. This study aimed to establish and validate PhA cutoff values for diagnosing malnutrition and sarcopenia in a Japanese cohort. Methods We retrospectively analyzed 337 Japanese patients with liver cirrhosis who were randomly assigned to training (n=235) and validation (n=102) groups. Optimal sex-specific PhA cutoff values were then determined to identify malnutrition and sarcopenia. Overall survival was compared to assess the prognostic value of PhA. Results PhA was positively correlated with the body mass index, albumin level, and other nutritional indices (all p<0.05). A lower PhA was associated with a poorer hepatic reserve, as indicated by the Child-Pugh and mALBI grades (p<0.001). A multivariate analysis identified the PhA as an independent predictor of malnutrition and sarcopenia (p<0.01). Patients in the low PhA group had a shorter overall survival (p=0.024). The optimal PhA cut-off values for malnutrition and sarcopenia were 4.8 for males and 4.2 for females (AUROCs:0.70-0.76). In the validation cohort, the PhA cutoff values showed good sensitivity (76.7%) and a negative predictive value (75.0%) for malnutrition. Conclusion We established and validated the first sex-specific PhA cutoff values for malnutrition in Japanese patients with cirrhosis, which were lower than those in Western populations. PhA independently predicts malnutrition, sarcopenia, and overall survival, thereby offering clinicians a simple, noninvasive screening tool to enhance nutritional assessment in routine practice. FAU - Haraguchi, Masafumi AU - Haraguchi M AD - Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Japan. FAU - Miuma, Satoshi AU - Miuma S AD - Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Japan. FAU - Nakao, Yasuhiko AU - Nakao Y AD - Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Japan. FAU - Fukushima, Masanori AU - Fukushima M AD - Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Japan. FAU - Sasaki, Ryu AU - Sasaki R AD - Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Japan. FAU - Takahata, Hideaki AU - Takahata H AD - Department of Rehabilitation Medicine, Nagasaki University Hospital, Japan. FAU - Miyaaki, Hisamitsu AU - Miyaaki H AD - Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Japan. LA - eng PT - Journal Article DEP - 20260407 PL - Japan TA - Intern Med JT - Internal medicine (Tokyo, Japan) JID - 9204241 SB - IM OTO - NOTNLM OT - Bioelectrical Impedance OT - Body Composition OT - Hand Strength OT - Liver Cirrhosis OT - Muscle Strength OT - Nutritional Status EDAT- 2026/04/09 00:33 MHDA- 2026/04/09 00:33 CRDT- 2026/04/08 21:33 PHST- 2026/04/09 00:33 [medline] PHST- 2026/04/09 00:33 [pubmed] PHST- 2026/04/08 21:33 [entrez] AID - 10.2169/internalmedicine.6677-25 [doi] PST - aheadofprint SO - Intern Med. 2026 Apr 7. doi: 10.2169/internalmedicine.6677-25. PMID- 41950074 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1984-0462 (Electronic) IS - 0103-0582 (Print) IS - 0103-0582 (Linking) VI - 44 DP - 2026 TI - NutriRisKids-ICU: Development and content validation of a nutritional risk screening tool for critically ill children and adolescents. PG - e2025246 LID - S0103-05822026000101009 [pii] LID - 10.1590/1984-0462/2026/44/2025246 [doi] LID - e2025246 AB - OBJECTIVE: The aim of this study was to develop and validate the content of a nutritional risk screening tool for critically ill children and adolescents in pediatric intensive care units (PICUs). METHODS: Care-convergent study for the development and content validation of an instrument for assessing nutritional risk in children admitted to the PICU. The initial development was based on a literature review and the clinical experience of the authors. Content validation was conducted using the Delphi technique in two successive rounds with intentionally selected experts, each with a minimum of 5 years of experience in pediatric intensive nutritional therapy (NT). Consensus analysis was performed using the content validity index (CVI), with minimum values of 0.70 for individual items and 0.90 for the overall instrument. RESULTS: Validation occurred in two rounds. In the first round, 18 experts suggested adjustments, and the revised version was reassessed by 12 experts in the second round. The final tool achieved an overall CVI of 0.958. The validated version included age subgroups, presence of chronic diseases, length of prior hospitalization, subjective impression of malnutrition risk, type of NT at admission, and C-reactive protein (CRP) levels. CONCLUSIONS: The nutritional risk screening tool for critically ill pediatric patients, named NutriRisKids-ICU, was developed, and its content was validated by expert consensus. The tool combines theoretical evidence and clinical expertise, showing potential for application in PICUs. However, further studies are needed to assess its applicability, sensitivity, and specificity. FAU - Souza, Veronica Ramos AU - Souza VR AUID- ORCID: 0009-0004-2023-7758 AD - Universidade de Sao Paulo - Sao Paulo, SP, Brazil. FAU - Trida, Vanessa Camargo AU - Trida VC AUID- ORCID: 0000-0002-7452-2472 AD - Universidade de Sao Paulo - Sao Paulo, SP, Brazil. FAU - Mazzoni, Beatriz Polisel AU - Mazzoni BP AUID- ORCID: 0000-0001-6333-5359 AD - Universidade de Sao Paulo - Sao Paulo, SP, Brazil. FAU - Gandolfo, Adriana Servilha AU - Gandolfo AS AUID- ORCID: 0000-0001-5416-6733 AD - Universidade de Sao Paulo - Sao Paulo, SP, Brazil. FAU - de Carvalho, Werther Brunow AU - de Carvalho WB AUID- ORCID: 0000-0002-9164-616X AD - Universidade de Sao Paulo - Sao Paulo, SP, Brazil. FAU - Delgado, Artur Figueiredo AU - Delgado AF AUID- ORCID: 0000-0003-4362-9880 AD - Universidade de Sao Paulo - Sao Paulo, SP, Brazil. FAU - Zamberlan, Patricia AU - Zamberlan P AUID- ORCID: 0000-0003-4118-9965 AD - Universidade de Sao Paulo - Sao Paulo, SP, Brazil. LA - eng PT - Journal Article PT - Validation Study DEP - 20260403 PL - Brazil TA - Rev Paul Pediatr JT - Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo JID - 9109353 SB - IM MH - Humans MH - *Critical Illness MH - Intensive Care Units, Pediatric MH - Adolescent MH - Child MH - *Nutrition Assessment MH - Risk Assessment/methods MH - Female MH - Male MH - *Malnutrition/diagnosis PMC - PMC13053041 EDAT- 2026/04/08 18:32 MHDA- 2026/04/08 18:33 PMCR- 2026/04/03 CRDT- 2026/04/08 13:13 PHST- 2025/09/01 00:00 [received] PHST- 2025/11/16 00:00 [accepted] PHST- 2026/04/08 18:33 [medline] PHST- 2026/04/08 18:32 [pubmed] PHST- 2026/04/08 13:13 [entrez] PHST- 2026/04/03 00:00 [pmc-release] AID - S0103-05822026000101009 [pii] AID - 10.1590/1984-0462/2026/44/2025246 [doi] PST - epublish SO - Rev Paul Pediatr. 2026 Apr 3;44:e2025246. doi: 10.1590/1984-0462/2026/44/2025246. eCollection 2026. PMID- 41949981 OWN - NLM STAT- MEDLINE DCOM- 20260702 LR - 20260702 IS - 1558-9129 (Electronic) IS - 0161-1461 (Linking) VI - 57 IP - 3 DP - 2026 Jul 2 TI - Development and Preliminary Outcomes of a Parent-Led Intervention for Malaysian School-Age Children With Cleft Lip and/or Palate. PG - 743-759 LID - 10.1044/2026_LSHSS-25-00133 [doi] AB - PURPOSE: Children with cleft lip and/or palate (CL/P) face psychosocial and communication challenges that may hinder peer relationships and emotional well-being. This study aimed to develop and evaluate the preliminary outcomes of the Module Klefiden, a parent-led intervention designed to improve psychosocial and communication functioning in Malaysian school-age children with CL/P. METHOD: Module activities were developed through the Nominal Group Technique (n = 12) and validated by an expert panel (n = 8). The module was then evaluated through a feasibility study with 10 parents, followed by preliminary outcomes involving 17 children. RESULTS: The Module Klefiden comprises 14 culturally tailored, strength-based activities addressing stigma, teasing, and resilience building. The content validity of the module was high (0.86). The feasibility study showed that most parents found the Module Klefiden practicable and acceptable, as indicated by the results of the Treatment Evaluation Inventory-Short Form (M = 37.08). In the preliminary outcomes study, the module was evaluated before and after the intervention in four domains of the Cleft Lip and/or Palate Questionnaire (CLEFT-Q). The experimental group showed significant improvements in psychological function (Z = -2.668, p = .008, r = .889) and speech distress (Z = -2.201, p = .028, r = .734). Both groups showed improvements in social participation (experimental: Z = -2.392, p = .017, r = .797; control: Z = -2.375, p = .018, r = .840). Qualitative data highlighted the children's increased confidence in discussing their cleft condition. At school, children still favored physical activities over speech-related tasks. CONCLUSIONS: The Module Klefiden shows promise in improving psychosocial and communication outcomes in children with CL/P. Its structured, parent-led approach fosters emotional resilience and self-assurance, addressing a critical gap in cleft care in Malaysia. Future research should explore its long-term, large-scale application. SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.31894306. FAU - Yusof, Safwan AU - Yusof S AUID- ORCID: 0000-0002-3692-5406 AD - Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur. FAU - Mohd Ibrahim, Hasherah AU - Mohd Ibrahim H AUID- ORCID: 0000-0002-9383-7541 AD - Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur. FAU - Bressmann, Tim AU - Bressmann T AUID- ORCID: 0000-0001-5675-0490 AD - Department of Speech-Language Pathology, University of Toronto, Ontario, Canada. LA - eng PT - Journal Article DEP - 20260408 PL - United States TA - Lang Speech Hear Serv Sch JT - Language, speech, and hearing services in schools JID - 0323431 SB - IM MH - Humans MH - *Cleft Lip/psychology/therapy MH - *Cleft Palate/psychology/therapy MH - Child MH - Female MH - Malaysia MH - Male MH - *Parents/psychology MH - Feasibility Studies MH - Surveys and Questionnaires EDAT- 2026/04/08 18:32 MHDA- 2026/07/02 12:34 CRDT- 2026/04/08 12:13 PHST- 2026/07/02 12:34 [medline] PHST- 2026/04/08 18:32 [pubmed] PHST- 2026/04/08 12:13 [entrez] AID - 10.1044/2026_LSHSS-25-00133 [doi] PST - ppublish SO - Lang Speech Hear Serv Sch. 2026 Jul 2;57(3):743-759. doi: 10.1044/2026_LSHSS-25-00133. Epub 2026 Apr 8. PMID- 41949007 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260714 IS - 1687-1634 (Electronic) IS - 1020-3397 (Linking) VI - 32 IP - 2 DP - 2026 Mar 5 TI - Smartphone addiction and motor-cognitive performance among adolescents in Tunisia. PG - 93-102 LID - 10.26719/2026.32.2.93 [doi] AB - BACKGROUND: Smartphone addiction among adolescents has emerged as a significant public health concern, with potential consequences for motor and cognitive development. AIM: To examine the associations between smartphone addiction and motor-cognitive performance among adolescents in Tunisia, using validated digital tools. METHODS: Between December 2023 and March 2024, we examined 270 students in 3 public middle schools in urban Tunisia. We assessed smartphone addiction using the validated Arabic version of the smartphone addiction scale short version; motor function using the Takei Grip‑D dynamometer, MySprint app and the Flamingo balance test; and cognitive function using the Vienna test system. Group comparisons were conducted using nonparametric tests; associations were examined using Spearman's correlations; and predictive effects were assessed using separate linear regression analyses adjusted for age, sex and body mass index (P > 0.05). RESULTS: Adolescents classified as addicted (n = 120) demonstrated significantly higher daily smartphone use (454.8 +/- 104.8 vs 172.1 +/- 108.6 minutes, P < 0.001), slower sprint time (6.09 +/- 0.70 vs 5.63 +/- 0.54 seconds, P < 0.001), reduced grip strength (22.3 +/- 3.5 vs 25.7 +/- 4.1 kg, P < 0.001), and lower cognitive accuracy despite faster reaction time (P < 0.01). Addiction severity independently predicted slower sprinting (beta = 0.32) and poorer postural stability (beta = 0.35, both P < 0.001). CONCLUSION: Smartphone addiction is linked to significant motor and cognitive impairment among adolescents in Tunisian schools, with addiction severity predicting slower sprinting and poorer postural stability. Early school-based interventions to promote healthy smartphone habits and physical activity may help prevent long-term motor-cognitive decline among adolescents in Tunisia. CI - Copyright (c) Authors 2026; Licensee: World Health Organization. EMHJ is an open-access journal. This paper is available under the Creative Commons Attribution Non-Commercial ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). FAU - Yaakoubi, Mohamed AU - Yaakoubi M AD - High Institute of Sports and Physical Education, University of Jendouba, Kef, Tunisia. AD - Research Unit, Physical Activity, Sport and Health, UR18JS01, National Observatory of Sport, Tunis, Tunisia. FAU - Ghorbel, Ahmed AU - Ghorbel A AD - High Institute of Sports and Physical Education, University of Jendouba, Kef, Tunisia. AD - Research Unit, Physical Activity, Sport and Health, UR18JS01, National Observatory of Sport, Tunis, Tunisia. FAU - Saddoud, Anis AU - Saddoud A AD - High Institute of Sports and Physical Education, University of Sfax, Sfax, Tunisia. FAU - Masmoudi, Liwa AU - Masmoudi L AD - Research Unit, Physical Activity, Sport and Health, UR18JS01, National Observatory of Sport, Tunis, Tunisia. AD - High Institute of Sports and Physical Education, University of Sfax, Sfax, Tunisia. FAU - Trabelsi, Omar AU - Trabelsi O AD - High Institute of Sports and Physical Education, University of Jendouba, Kef, Tunisia. AD - Research Unit, Physical Activity, Sport and Health, UR18JS01, National Observatory of Sport, Tunis, Tunisia. AD - High Institute of Applied Studies in Humanities, Department of Education Sciences, University of Monastir, Mahdia, Tunisia. FAU - Farhat, Faical AU - Farhat F AD - Research Unit, Physical Activity, Sport and Health, UR18JS01, National Observatory of Sport, Tunis, Tunisia. AD - High Institute of Sports and Physical Education, University of Gafsa, Tunisia. AD - Faculty of Medicine, University of Sfax, Sfax, Tunisia. FAU - Gharbi, Adnene AU - Gharbi A AD - Research Unit, Physical Activity, Sport and Health, UR18JS01, National Observatory of Sport, Tunis, Tunisia. AD - High Institute of Sports and Physical Education, University of Sfax, Sfax, Tunisia. LA - eng PT - Journal Article DEP - 20260305 PL - Egypt TA - East Mediterr Health J JT - Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit JID - 9608387 SB - IM MH - Humans MH - Tunisia/epidemiology MH - Adolescent MH - *Smartphone MH - Female MH - *Cognition MH - Male MH - *Internet Addiction Disorder/epidemiology MH - *Behavior, Addictive/epidemiology OTO - NOTNLM OT - Tunisia OT - adolescent health OT - cognitive function OT - motor skills OT - smartphone addiction EDAT- 2026/04/08 12:35 MHDA- 2026/04/08 12:36 CRDT- 2026/04/08 06:53 PHST- 2025/04/25 00:00 [received] PHST- 2025/09/30 00:00 [accepted] PHST- 2026/04/08 12:36 [medline] PHST- 2026/04/08 12:35 [pubmed] PHST- 2026/04/08 06:53 [entrez] AID - 10.26719/2026.32.2.93 [doi] PST - epublish SO - East Mediterr Health J. 2026 Mar 5;32(2):93-102. doi: 10.26719/2026.32.2.93. PMID- 41947098 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Apr 7 TI - Associations between digital healthy diet literacy, artificial intelligence attitudes, mediterranean diet adherence, and health-related quality of life in adults. LID - 10.1186/s12889-026-27238-y [doi] LID - 1598 AB - OBJECTIVE: In the digital age, the ability to critically evaluate online nutritional information is of paramount importance. This study aimed to examine the relationships between digital healthy diet literacy (DHDL), attitudes towards artificial intelligence (AI), adherence to the Mediterranean Diet (MD), and the physical and mental components of health-related quality of life in adults. METHODS: This cross-sectional study was conducted in Ankara, Turkey, using snowball sampling and a web-based questionnaire; 1240 adults (740 women, 500 men) aged 18-65 were included in the study. Data were collected through a web-based questionnaire that included demographic information, self-reported anthropometric measurements, and validated scales. The scales used include: Digital Eating Literacy Scale, Attitudes toward Artificial Intelligence Scale, Short Form-12 Quality of Life Scale (SF-12), and Mediterranean Diet Adherence Scale (MEDAS). RESULTS: DHDL scores showed significant positive correlations with AI attitude scores (r = 0.195), the physical (r = 0.218) and mental (r = 0.291) components of health-related quality of life, and MD adherence (r = 0.206) (p < 0.001 for all). Similarly, higher attitudes toward AI were significantly associated with better MD adherence (r = 0.250) and higher physical (r = 0.138) and mental (r = 0.129) quality of life. Linear regression analyses indicated that demographic and socioeconomic factors such as gender, age, marital status, education and income level, and employment status were significant predictors of digital healthy diet literacy (DHDL), AI attitudes, Physical Component Summary-12 (PCS-12), Mental Component Summary-12 (MCS-12), and MEDAS scores (p < 0.05). CONCLUSIONS: High DHDL levels, positive attitudes toward AI, and high adherence with MD are interrelated and positively correlated with better health-related quality of life. In public health strategies, incorporating holistic interventions that improve DHDL, encourage positive interaction with AI-based health tools, and support adherence to evidence-based dietary patterns such as the MD may contribute to improved overall well-being. FAU - Guler, Ummugulsum AU - Guler U AUID- ORCID: 0009-0001-3352-6047 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkiye, Turkey. FAU - Mengi̇ Celi̇k, Ozge AU - Mengi̇ Celi̇k O AUID- ORCID: 0000-0002-0298-9591 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Faculty, University of Health Sciences, Ankara, Turkiye, Turkey. ozgeemengi@gmail.com. FAU - Baspinar, Emine Nefise AU - Baspinar EN AUID- ORCID: 0009-0007-5073-0959 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkiye, Turkey. FAU - Degi̇rmenci̇oglu, Elif AU - Degi̇rmenci̇oglu E AUID- ORCID: 0009-0005-5332-8493 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkiye, Turkey. FAU - Eser, Binnaz AU - Eser B AUID- ORCID: 0009-0007-7584-6763 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkiye, Turkey. FAU - Serenli̇oglu, Dila AU - Serenli̇oglu D AUID- ORCID: 0009-0000-0056-7224 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkiye, Turkey. FAU - Kilic, Gulnur AU - Kilic G AUID- ORCID: 0009-0004-6413-1074 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkiye, Turkey. FAU - Gencoglu, Irem AU - Gencoglu I AUID- ORCID: 0009-0009-9426-2135 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkiye, Turkey. FAU - Kaya, Melike AU - Kaya M AUID- ORCID: 0009-0007-6212-2985 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkiye, Turkey. FAU - Sariteke, Yaprak AU - Sariteke Y AUID- ORCID: 0009-0002-9007-6633 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkiye, Turkey. LA - eng PT - Journal Article DEP - 20260407 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - *Quality of Life/psychology MH - Adult MH - Male MH - *Diet, Mediterranean/statistics & numerical data/psychology MH - Middle Aged MH - Cross-Sectional Studies MH - Adolescent MH - *Health Literacy/statistics & numerical data MH - Young Adult MH - *Artificial Intelligence/statistics & numerical data MH - *Diet, Healthy/statistics & numerical data/psychology MH - Aged MH - Turkey MH - Surveys and Questionnaires MH - Digital Media MH - Digital Health MH - *Patient Compliance/statistics & numerical data PMC - PMC13192162 OTO - NOTNLM OT - Artificial intelligence OT - Digital health diet literacy OT - Health-related quality of life OT - Mediterranean diet COIS- Declarations. Ethics approval and consent to participate: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was conducted with the approval of the University of Health Sciences Gulhane Scientific Research Ethics Committee, numbered 2025/535. Informed consent was obtained from all participants included in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/08 00:30 MHDA- 2026/06/27 18:38 PMCR- 2026/04/07 CRDT- 2026/04/07 23:58 PHST- 2026/01/15 00:00 [received] PHST- 2026/03/27 00:00 [accepted] PHST- 2026/06/27 18:38 [medline] PHST- 2026/04/08 00:30 [pubmed] PHST- 2026/04/07 23:58 [entrez] PHST- 2026/04/07 00:00 [pmc-release] AID - 10.1186/s12889-026-27238-y [pii] AID - 27238 [pii] AID - 10.1186/s12889-026-27238-y [doi] PST - epublish SO - BMC Public Health. 2026 Apr 7;26(1):1598. doi: 10.1186/s12889-026-27238-y. PMID- 41946270 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260714 IS - 1476-5616 (Electronic) IS - 0033-3506 (Linking) VI - 255 DP - 2026 Jun TI - The impact of public health service on rural children's health: Quasi-experimental evidence from China. PG - 106263 LID - S0033-3506(26)00132-0 [pii] LID - 10.1016/j.puhe.2026.106263 [doi] AB - OBJECTIVES: This study evaluates the impact of a major maternal and child health service program on the health outcomes of children in rural China. STUDY DESIGN: Quasi-experimental study. METHODS: We utilize data from the China Family Panel Studies (CFPS) spanning 2012 to 2018, leveraging a regression discontinuity (RD) design with March 2006 as the cutoff to identify the program's causal effects. Our empirical strategy includes a series of robustness checks, such as RD validity tests, alternative bandwidths and functional forms, placebo cutoffs, exclusion of a confounding policy, and a combined RD-DID approach. RESULTS: The program yields significant improvements in rural children's health. We find a 5% reduction in hospitalization rates and a 53.7% increase in hospital delivery rates, accompanied by improvements in nutritional status, as reflected by a 0.082 increase in BMI Z-scores. Placebo test results show no significant effects, supporting our identification strategy and suggesting a narrowing of the urban-rural health gap. Additional analysis indicates that the program significantly reduces out-of-pocket medical expenditures for rural households, with particularly pronounced benefits for low-income families. CONCLUSIONS: The maternal and child health service program has proven to be an effective intervention for improving child health and reducing health disparities, particularly between urban and rural areas as well as within rural communities. These findings underscore the program's critical role in promoting health equity and accelerating progress toward universal health coverage. CI - Copyright (c) 2026 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved. FAU - Shen, Taotao AU - Shen T AD - Institute of Financial Risk Management, Shanxi University of Finance and Economics, No.140, Wucheng Road, Xiaodian District, Taiyuan, 030006, China. Electronic address: shyercz@163.com. FAU - Liu, Huan AU - Liu H AD - College of Economics and Management, Nanjing Agricultural University, No.1, Weigang Road, Xuanwu District, Nanjing, 210095, China. Electronic address: lhnenu0922@163.com. LA - eng PT - Journal Article DEP - 20260406 PL - Netherlands TA - Public Health JT - Public health JID - 0376507 SB - IM MH - Humans MH - China MH - *Child Health/statistics & numerical data MH - Female MH - Child MH - *Rural Population/statistics & numerical data MH - Child, Preschool MH - Male MH - Infant MH - Program Evaluation OTO - NOTNLM OT - Child health OT - Early childhood development OT - Health services OT - Maternal and child OT - Rural China COIS- Declaration of competing interest The authors declare that they have no competing interests. EDAT- 2026/04/08 00:30 MHDA- 2026/05/03 05:27 CRDT- 2026/04/07 18:08 PHST- 2025/11/14 00:00 [received] PHST- 2026/02/18 00:00 [revised] PHST- 2026/03/19 00:00 [accepted] PHST- 2026/05/03 05:27 [medline] PHST- 2026/04/08 00:30 [pubmed] PHST- 2026/04/07 18:08 [entrez] AID - S0033-3506(26)00132-0 [pii] AID - 10.1016/j.puhe.2026.106263 [doi] PST - ppublish SO - Public Health. 2026 Jun;255:106263. doi: 10.1016/j.puhe.2026.106263. Epub 2026 Apr 6. PMID- 41944765 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260715 IS - 2214-0190 (Electronic) IS - 0895-3988 (Linking) VI - 39 IP - 3 DP - 2026 Mar 20 TI - Levels and Disparities of 24-hour Movement Behaviors of Chinese Children Aged 3-5 Years: A Nationally Representative Cross-sectional Study (2019-2021). PG - 285-296 LID - 10.3967/bes2025.151 [doi] AB - OBJECTIVE: This study aimed to describe 24-hour movement behaviors, including physical activity, sedentary behavior, and sleep period, among Chinese preschoolers using nationally representative data, and examine disparities by age, gender, and residence. METHODS: A cross-sectional analysis was conducted using data from the China National Nutrition and Health Systematic Survey for Children (2019-2021), including 10,935 children aged 3-5 years. Daily total time of physical activity (TPA), total time of sedentary behaviors (TSB), and total sleep period (TSP) was collected via validated structured questionnaires. Physical inactivity was defined as < 180 minutes of TPA per day. RESULTS: Median TPA was 121.4 ( IQR: 71.4-209.6) minutes/day, and TSB was 231.4 ( IQR: 175.0-304.3) minutes/day, with 11.46 +/- 1.00 hours/day average TSP. Overall, 68.8% were physically inactive, with higher prevalence in rural (73.3%) versus urban areas (64.8%, P < 0.001). TPA and TSB increased with age, while TSP decreased (all P < 0.001). No significant gender differences were observed. CONCLUSION: Most Chinese preschoolers exhibit insufficient physical activity and excessive sedentary behaviors, with notable urban-rural disparities and an escalating trend of ageing. Continuous monitoring and targeted interventions, especially in rural areas, are urgently needed. CI - Copyright (c) 2026 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved. FAU - Duan, Yi Fan AU - Duan YF AD - National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. Key Laboratory of Public Nutrition and Health, National Health Commission of the People's Republic of China. Key Laboratory of Human Breast Milk Science, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Zhang, Ji AU - Zhang J AD - School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China. FAU - Guo, Lin Xiao AU - Guo LX AD - National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. Key Laboratory of Public Nutrition and Health, National Health Commission of the People's Republic of China. Key Laboratory of Human Breast Milk Science, Chinese Center for Disease Control and Prevention, Beijing 100050, China;Guangdong Polytechnic of Science and Trade, Guangzhou 510430, Guangdong, China. FAU - Pang, Xue Hong AU - Pang XH AD - National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. Key Laboratory of Public Nutrition and Health, National Health Commission of the People's Republic of China. Key Laboratory of Human Breast Milk Science, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Zhang, Qian AU - Zhang Q AD - National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. Key Laboratory of Public Nutrition and Health, National Health Commission of the People's Republic of China. Key Laboratory of Human Breast Milk Science, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Wang, Yu Ying AU - Wang YY AD - National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. Key Laboratory of Public Nutrition and Health, National Health Commission of the People's Republic of China. Key Laboratory of Human Breast Milk Science, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Xu, Tao AU - Xu T AD - National Center for Women and Children's Health, National Health Commission of the People's Republic of China, Beijing 100081, China. FAU - Chen, Bo Wen AU - Chen BW AD - Capital Institute of Pediatrics, Beijing 100020, China. FAU - Yang, Zhen Yu AU - Yang ZY AD - National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. Key Laboratory of Public Nutrition and Health, National Health Commission of the People's Republic of China. Key Laboratory of Human Breast Milk Science, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Zhao, Wen Hua AU - Zhao WH AD - National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. Key Laboratory of Public Nutrition and Health, National Health Commission of the People's Republic of China. Key Laboratory of Human Breast Milk Science, Chinese Center for Disease Control and Prevention, Beijing 100050, China. LA - eng PT - Journal Article PL - China TA - Biomed Environ Sci JT - Biomedical and environmental sciences : BES JID - 8909524 RN - Chinese people SB - IM MH - Humans MH - Cross-Sectional Studies MH - China MH - Female MH - Male MH - *Sedentary Behavior MH - Child, Preschool MH - *Sleep MH - *Exercise MH - Sleep Duration MH - East Asian People OTO - NOTNLM OT - Physical activity OT - Physical inactivity OT - Preschool children OT - Sedentary behavior OT - Sleep duration OT - Urban-rural disparity EDAT- 2026/04/07 12:32 MHDA- 2026/04/07 12:33 CRDT- 2026/04/07 10:13 PHST- 2025/04/30 00:00 [received] PHST- 2025/10/13 00:00 [accepted] PHST- 2026/04/07 12:33 [medline] PHST- 2026/04/07 12:32 [pubmed] PHST- 2026/04/07 10:13 [entrez] AID - 10.3967/bes2025.151 [doi] PST - ppublish SO - Biomed Environ Sci. 2026 Mar 20;39(3):285-296. doi: 10.3967/bes2025.151. PMID- 41944689 OWN - NLM STAT- MEDLINE DCOM- 20260723 LR - 20260723 IS - 1533-4287 (Electronic) IS - 1064-8011 (Linking) VI - 40 IP - 8 DP - 2026 Aug 1 TI - Accelerometry Insights Into Gym-Based Plyometric Exercises; Evaluating Metrics, Reliability, and Sensor Placement. PG - e784-e791 LID - 10.1519/JSC.0000000000005424 [doi] AB - McGillivray, I, Murphy, A, Reid, M, Perri, T, and Duffield, R. Accelerometry insights into gym-based plyometric exercises; evaluating metrics, reliability, and sensor placement. J Strength Cond Res 40(8): e784-e791, 2026-Quantification of training load is important for athletic performance, yet traditional field-based accelerometry often fails to capture gym-based training demands, particularly in the vertical plane. This study investigates the use of triaxial accelerometry for assessing training load in gym-based plyometric exercises, examining the influence of sensor placement and the reliability of accelerometry-derived metrics. Ten elite youth tennis players (16.0 +/- 1.6 years) completed a standardized plyometric session on 2 occasions, consisting of 4 sets of 7 exercises, performed in a superset sequence. Inertial measurement units (IMUs) were worn at 4 anatomical locations (thoracic spine, lumbar spine, left ankle, right ankle), collecting 4 key metrics: peak upward acceleration (PUpAcc), 1D upward PlayerLoad (1DPL-up), 2D PlayerLoad (2DPL), and 3D PlayerLoad (3DPL). Results showed skater hops consistently produced the lowest acceleration magnitudes, whereas altitude landings recorded the highest. Ankle-mounted sensors recorded significantly higher acceleration values than thoracic and lumbar placements ( p < 0.05), confirming the attenuation of signals up the body. PlayerLoad metrics demonstrated strong agreement across sensor locations ( r = 0.50-0.96) in 119/126 comparisons, whereas PUpAcc showed lower associations ( r = 0.01-0.57). Moderate to good reliability values (intraclass correlation coefficient = 0.50-0.84) existed across all metrics, with greater consistency in PlayerLoad metrics compared with PUpAcc. Overall, sensor placement influences accelerometry-derived measures of plyometric activities, with PlayerLoad metrics demonstrating intersensor agreement and reliability across placements. Although thoracic-mounted IMUs capture whole-body motion, they may underestimate lower-limb loading. These preliminary findings support using PlayerLoad metrics for monitoring gym-based plyometrics while highlighting the need for further research into PUpAcc as a measure of impact-related acceleration. CI - Copyright (c) 2026 National Strength and Conditioning Association. FAU - McGillivray, Isabel AU - McGillivray I AD - School of Sport, Exercise & Rehabilitation, Faculty of Health, University of Technology Sydney, New South Wales, Australia; and. AD - Tennis Australia, Melbourne, Victoria, Australia. FAU - Murphy, Alistair AU - Murphy A AD - Tennis Australia, Melbourne, Victoria, Australia. FAU - Reid, Machar AU - Reid M AD - Tennis Australia, Melbourne, Victoria, Australia. FAU - Perri, Thomas AU - Perri T AD - Tennis Australia, Melbourne, Victoria, Australia. FAU - Duffield, Rob AU - Duffield R AD - School of Sport, Exercise & Rehabilitation, Faculty of Health, University of Technology Sydney, New South Wales, Australia; and. LA - eng PT - Journal Article DEP - 20260408 PL - United States TA - J Strength Cond Res JT - Journal of strength and conditioning research JID - 9415084 SB - IM MH - Humans MH - *Accelerometry/methods/instrumentation MH - Reproducibility of Results MH - *Plyometric Exercise/methods MH - Adolescent MH - Tennis/physiology MH - Acceleration MH - Ankle/physiology MH - Male MH - Lumbar Vertebrae/physiology OTO - NOTNLM OT - plyometric training OT - tennis OT - training load monitoring OT - wearable technology EDAT- 2026/04/07 12:32 MHDA- 2026/07/23 12:37 CRDT- 2026/04/07 09:43 PHST- 2026/07/23 12:37 [medline] PHST- 2026/04/07 12:32 [pubmed] PHST- 2026/04/07 09:43 [entrez] AID - 00124278-990000000-00947 [pii] AID - 10.1519/JSC.0000000000005424 [doi] PST - ppublish SO - J Strength Cond Res. 2026 Aug 1;40(8):e784-e791. doi: 10.1519/JSC.0000000000005424. Epub 2026 Apr 8. PMID- 41943951 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260825 IS - 1541-3144 (Electronic) IS - 0194-2638 (Linking) VI - 46 IP - 5 DP - 2026 TI - Feeding Self-Help Skills and Adaptive Behavior Are Related to Feeding Challenge Severity in Autistic Children. PG - 963-979 LID - 10.1080/01942638.2026.2652045 [doi] AB - AIMS: This project aimed to (1) Describe feeding self-help skills in autistic children with feeding challenges and (2) Identify the relationships among feeding self-help skills, feeding challenge severity, family mealtime factors, and adaptive behavior. METHODS: This study used data from a cross-sectional national survey of 358 caregivers of autistic children (ages 2-12 years) with feeding challenges, recruited through a national research registry. Data were captured using validated caregiver-report measures. Descriptive statistics were completed to characterize feeding self-help skills and additional variables within the sample. Pearson's R correlations were run to investigate relationships among variables. RESULTS: Feeding self-help skills, feeding challenge severity, and adaptive behavior scores were widely heterogeneous. Overall, children in the study required higher levels of support from caregivers to participate in feeding and had lower adaptive behavior than expected for their age. Significant Pearson r correlations ranging from 0.11 to 0.60 were observed between feeding self-help skills, feeding challenge severity, family mealtime factors, and adaptive behavior. CONCLUSIONS: Feeding self-help skills and adaptive behavior are essential to evaluate in autistic children with feeding challenges. Future research should explore component skills, (e.g. use of utensils) in addition to behavior and sensory components of feeding to inform child-centered evaluation and intervention. FAU - St John, Brittany M AU - St John BM AD - Waisman Center, University of Wisconsin, Madison, WI, USA. AD - Department of Rehabilitation Medicine, Division of Occupational Therapy, University of Washington, Seattle, WA, USA. FAU - Laufenberg, Hannah AU - Laufenberg H AD - Department of Kinesiology, Occupational Therapy Program, University of Wisconsin at Madison, Madison, WI, USA. FAU - Sommers, Mary AU - Sommers M AD - Department of Kinesiology, Occupational Therapy Program, University of Wisconsin at Madison, Madison, WI, USA. FAU - Sylvester, Gina AU - Sylvester G AD - Department of Kinesiology, Occupational Therapy Program, University of Wisconsin at Madison, Madison, WI, USA. FAU - Ausderau, Karla K AU - Ausderau KK AD - Waisman Center, University of Wisconsin, Madison, WI, USA. AD - Department of Kinesiology, Occupational Therapy Program, University of Wisconsin at Madison, Madison, WI, USA. LA - eng PT - Journal Article DEP - 20260407 PL - England TA - Phys Occup Ther Pediatr JT - Physical & occupational therapy in pediatrics JID - 8109120 SB - IM MH - Humans MH - Child, Preschool MH - Child MH - Male MH - *Adaptation, Psychological MH - Cross-Sectional Studies MH - Female MH - *Autistic Disorder/psychology/physiopathology MH - *Feeding Behavior/psychology MH - Meals MH - Severity of Illness Index MH - Caregivers MH - *Self Care OTO - NOTNLM OT - Adaptive behavior OT - autism OT - family mealtime OT - feeding challenges OT - feeding self-help skills EDAT- 2026/04/07 06:31 MHDA- 2026/08/25 11:38 CRDT- 2026/04/07 04:33 PHST- 2026/08/25 11:38 [medline] PHST- 2026/04/07 06:31 [pubmed] PHST- 2026/04/07 04:33 [entrez] AID - 10.1080/01942638.2026.2652045 [doi] PST - ppublish SO - Phys Occup Ther Pediatr. 2026;46(5):963-979. doi: 10.1080/01942638.2026.2652045. Epub 2026 Apr 7. PMID- 41942896 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260926 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Apr 6 TI - MIDO first childhood: assessment of growth and development in early childhood among vulnerable Mexican communities. LID - 10.1186/s12889-026-27181-y [doi] LID - 1592 AB - BACKGROUND: Early childhood health in Mexico is characterized by chronic undernutrition, excess weight, and risk of developmental delay, particularly among children living in socioeconomic vulnerability. Despite national statistics, integrated and standardized screening within routine primary healthcare remains limited. MIDO First Childhood is a digital health strategy that has an interoperable digital platform to support standardized assessment of child growth and development in primary healthcare settings. The objective of this study was to describe the health, nutritional, and developmental profiles of children assessed through MIDO First Childhood between 2019 and 2024. METHODS: We conducted a cross-sectional descriptive analysis of 18,197 children aged five years or younger assessed through MIDO First Childhood in primary healthcare facilities across eight Mexican states. The first recorded assessment per child with complete anthropometric and developmental data was included. Variables comprised sociodemographic characteristics, perinatal and health-related factors, standardized anthropometric indicators based on the World Health Organization growth standards, and child development assessed using the validated Early Development Instrument screening tool. Sex differences were examined using chi-square and Student's t tests. RESULTS: The coexistence of undernutrition and excess weight observed in our sample is consistent with national statistics, describing the double burden of malnutrition among young children in Mexico. These findings highlight the complexity of nutritional challenges faced in vulnerable populations within primary healthcare settings: 8.4% presented stunting or severe stunting, while 7.9% were overweight or obese. Only 65.3% achieved age-appropriate development. This proportion dropped sharply to 46.1% in children aged 31-36 months. Significant sex disparities were observed: boys had a higher prevalence of stunting (9.5% vs. 7.1%, p < 0.001), obesity (3.1% vs. 2.6%, p = 0.002), and were significantly more likely to experience critical neonatal events (7.5% vs. 5.7%, p < 0.001). CONCLUSIONS: This analysis documents a substantial prevalence of nutritional and developmental risk among children assessed through MIDO First Childhood, particularly among boys and in younger age groups. The implementation of the digital health strategy and the use of a standardized digital platform facilitates systematic identification of growth and developmental risks within primary healthcare settings. These findings provide descriptive evidence relevant for early screening and ongoing monitoring efforts in socioeconomically vulnerable populations in Mexico. FAU - Martinez-Silva, Gisela AU - Martinez-Silva G AUID- ORCID: 0000-0003-1431-9410 AD - Carlos Slim Foundation, Mexico City, Mexico. FAU - Martinez-Juarez, Luis-Alberto AU - Martinez-Juarez LA AUID- ORCID: 0000-0001-7550-7867 AD - Humanitarian and Conflict Response Institute, University of Manchester, Manchester, UK. FAU - Montoya, Alejandra AU - Montoya A AUID- ORCID: 0000-0002-9466-8452 AD - Center for Population Health Research, National Institute of Public Health (INSP), Cuernavaca, Morelos, Mexico. airainmr@fundacioncarlosslim.org. FAU - Falcon-Lezama, Jorge-Abelardo AU - Falcon-Lezama JA AUID- ORCID: 0000-0001-9081-4064 AD - Carlos Slim Foundation, Mexico City, Mexico. FAU - Alvarez-Hernandez, Diego-Abelardo AU - Alvarez-Hernandez DA AUID- ORCID: 0000-0003-2340-6639 AD - Carlos Slim Foundation, Mexico City, Mexico. FAU - Camacho-More, Diana AU - Camacho-More D AUID- ORCID: 0009-0007-6020-2850 AD - Carlos Slim Foundation, Mexico City, Mexico. FAU - Garcia-Cerde, Rodrigo AU - Garcia-Cerde R AUID- ORCID: 0000-0002-9973-878X AD - Carlos Slim Foundation, Mexico City, Mexico. FAU - Mujica-Rosales, Ricardo AU - Mujica-Rosales R AUID- ORCID: 0000-0001-6320-827X AD - Carlos Slim Foundation, Mexico City, Mexico. FAU - Saucedo-Martinez, Rodrigo AU - Saucedo-Martinez R AUID- ORCID: 0000-0002-5849-693X AD - Carlos Slim Foundation, Mexico City, Mexico. FAU - Gallardo-Rincon, Hector AU - Gallardo-Rincon H AUID- ORCID: 0000-0002-0811-4606 AD - University Center for Health Sciences (CUCS), University of Guadalajara, Guadalajara, Jalisco, Mexico. FAU - Tapia-Conyer, Roberto AU - Tapia-Conyer R AUID- ORCID: 0000-0001-9425-7322 AD - Faculty of Medicine, National Autonomous University of Mexico (UNAM), Mexico City, Mexico. LA - eng PT - Journal Article DEP - 20260406 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Mexico/epidemiology MH - Cross-Sectional Studies MH - Male MH - Child, Preschool MH - *Vulnerable Populations/statistics & numerical data MH - *Child Development MH - Infant MH - Female MH - Primary Health Care MH - Anthropometry MH - Socioeconomic Factors PMC - PMC13192147 OTO - NOTNLM OT - Child development OT - Child, preschool OT - Community-based health assessment OT - Growth and development OT - Health status disparities OT - Medical informatics applications OT - Mexico OT - Nutritional status OT - Overweight and obesity OT - Primary healthcare COIS- Declarations. Ethics approval and consent to participate: This study is a secondary analysis of de-identified operational data. According to the Mexican General Health Law on Health Research (Reglamento de la Ley General de Salud en Materia de Investigacion para la Salud), this study is classified as "Risk-Free" (Category I), as it relies on retrospective documentary research where sensitive data is protected. Therefore, a specific IRB approval for this manuscript or individual informed consent for research was not required by national regulations. The use of the platform is governed by institutional collaboration agreements that strictly ensure data confidentiality. The study adhered to the ethical principles of the Declaration of Helsinki, particularly regarding the protection of anonymity, confidentiality, and the responsible handling of health information. Consent for publication: Not applicable. The study used anonymized, secondary data collected as part of routine health assessments. Competing interests: The authors declare no competing interests. EDAT- 2026/04/07 00:31 MHDA- 2026/06/27 12:37 PMCR- 2026/04/06 CRDT- 2026/04/06 23:44 PHST- 2025/11/13 00:00 [received] PHST- 2026/03/24 00:00 [accepted] PHST- 2026/06/27 12:37 [medline] PHST- 2026/04/07 00:31 [pubmed] PHST- 2026/04/06 23:44 [entrez] PHST- 2026/04/06 00:00 [pmc-release] AID - 10.1186/s12889-026-27181-y [pii] AID - 27181 [pii] AID - 10.1186/s12889-026-27181-y [doi] PST - epublish SO - BMC Public Health. 2026 Apr 6;26(1):1592. doi: 10.1186/s12889-026-27181-y. PMID- 41942730 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20261009 IS - 1432-198X (Electronic) IS - 0931-041X (Print) IS - 0931-041X (Linking) VI - 41 IP - 11 DP - 2026 Nov TI - Physical activity among children and young people with chronic kidney diseases: a scoping review. PG - 3713-3747 LID - 10.1007/s00467-025-07142-0 [doi] AB - Promoting physical activity is a global initiative. However, published systematic syntheses regarding physical activity among children and young people with chronic kidney disease (CKD) are limited. The aim of this review was to determine the evidence relating to physical activity among children and young people with CKD and identify research gaps. A comprehensive search across seven databases was conducted, and two reviewers screened and synthesised the data. Fifty-seven primary studies were included. Most studies were observational, conducted in Europe and North America, and focused on kidney transplant recipients. Physical activity levels measured by various parameters, tools, and reporting methods showed children with CKD had a lower or similar percentage of physical activity participation, intensity, frequency, duration, and overall activeness compared with healthy controls. Associations between physical activity and sex, age, CKD stages, and outcomes varied in size, direction, and strength among studies. No prospective longitudinal studies have examined the associations between physical activity and CKD progression. Nor did any explicitly describe children's/carer's experience of engaging in physical activity, although five qualitative studies reported impacts and adaptations in children with different CKD stages. Most interventions described were short-term (<6 months) home-based exercise training programmes incorporating endurance, resistance, or flexibility elements. In conclusion, evidence on physical activity in children with CKD is predominantly quantitative, cross-sectional, relying on self-reported data, and focusing primarily on adolescents and kidney transplant recipients. Further research should establish more precise physical activity estimates using validated, standardised measures across CKD stages and diverse populations. CI - (c) 2026. The Author(s). FAU - Zhao, Rui AU - Zhao R AUID- ORCID: 0000-0002-2699-1274 AD - Bristol Medical School, University of Bristol, Bristol, BS8 1UD, UK. rui.zhao@bristol.ac.uk. FAU - Yu, Minghui AU - Yu M AD - Nephrology Department, Children's Hospital of Fudan University, Shanghai, 201102, China. FAU - Coward, Richard J M AU - Coward RJM AD - Bristol Medical School, University of Bristol, Bristol, BS8 1UD, UK. FAU - Townsend, Nick AU - Townsend N AD - School for Policy Studies, University of Bristol, Bristol, BS8 1TZ, UK. FAU - Plumb, Lucy AU - Plumb L AD - Bristol Medical School, University of Bristol, Bristol, BS8 1UD, UK. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260406 PL - Germany TA - Pediatr Nephrol JT - Pediatric nephrology (Berlin, Germany) JID - 8708728 SB - IM MH - Humans MH - Child MH - *Renal Insufficiency, Chronic/physiopathology/therapy MH - Adolescent MH - *Exercise/physiology MH - Kidney Transplantation MH - Evidence Gaps MH - Disease Progression MH - Exercise Therapy/methods PMC - PMC13612716 OTO - NOTNLM OT - Adolescent OT - Children OT - Chronic kidney disease OT - Physical activity OT - Scoping review COIS- Declarations. Conflict of interest: The authors declare no competing interests. EDAT- 2026/04/07 00:31 MHDA- 2026/09/25 05:31 PMCR- 2026/04/06 CRDT- 2026/04/06 23:21 PHST- 2025/08/05 00:00 [received] PHST- 2025/12/19 00:00 [accepted] PHST- 2025/12/11 00:00 [revised] PHST- 2026/09/25 05:31 [medline] PHST- 2026/04/07 00:31 [pubmed] PHST- 2026/04/06 23:21 [entrez] PHST- 2026/04/06 00:00 [pmc-release] AID - 10.1007/s00467-025-07142-0 [pii] AID - 7142 [pii] AID - 10.1007/s00467-025-07142-0 [doi] PST - ppublish SO - Pediatr Nephrol. 2026 Nov;41(11):3713-3747. doi: 10.1007/s00467-025-07142-0. Epub 2026 Apr 6. PMID- 41941459 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 4 DP - 2026 TI - Determinants of stunting among 0-59 months children in Lesotho: A multilevel analysis of 2023/24 Demographic and Health Survey. PG - e0342073 LID - 10.1371/journal.pone.0342073 [doi] LID - e0342073 AB - BACKGROUND: Stunting is height for age below minus 2 standard deviations of the World Health Organization standard. It affected more than one-third of children in Lesotho. Few studies applied multilevel model to identify individual, household, and community-level determinants. This study aimed to assess the prevalence and multilevel determinants of stunting among children aged 0-59 months in Lesotho using data from the 2023/24 Demographic and Health Survey. METHODS: We included a weighted 1,488 children aged 0-59 months across 400 enumeration areas. The weighted prevalence of stunting was determined. Individual and community level determinants of stunting were identified at a 0.05 level of significance. Models were compared using Akaike Information Criterion (AIC), Intraclass Correlation Coefficient (ICC), and Proportional Change in Variance (PCV). RESULTS: Prevalence of stunting was 35.59% (95% CI: 33.20-38.06). Its determinants were male (AOR = 1.41; 95% CI: 1.09-1.82), age 12-23 months (AOR = 2.44; 95% CI: 1.48-4.14) and 24-59 months (AOR = 1.98; 95% CI: 1.20-3.24), 4-7 birth order (AOR = 1.43; 95% CI: 1.01-2.03), and poor (AOR = 2.58; 95% CI: 1.85-3.59) and middle wealth index (AOR = 2.03; 95% CI: 1.37-3.03). Qacha's Nek, Thaba-Tseka, Mohale's Hoek, and Quthing have a higher prevalence of stunting. CONCLUSION: 35.59% of children 0-59 months in Lesotho are stunted. Its determinants were male, age 12-23 and 24-59 months, poor and middle wealth, and higher birth order. Ministry of Health, Non-governmental organizations, and community health workers should therefore strengthen age-specific, equity-driven nutrition programs. CI - Copyright: (c) 2026 Solbana et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Solbana, Lencho Kajela AU - Solbana LK AUID- ORCID: 0000-0002-3155-9363 AD - School of Public Health, Wollega University, Nekemte, Oromia, Ethiopia. FAU - Belay Keno, Firezer AU - Belay Keno F AUID- ORCID: 0000-0001-7111-4521 AD - School of Public Health, Wollega University, Nekemte, Oromia, Ethiopia. FAU - Negera, Atoma AU - Negera A AD - Department of Nursing, Mattu University, Mattu, Oromia, Ethiopia. FAU - Kejela, Baru Legesse AU - Kejela BL AD - Wollega University comprehensive specialized hospital, Wollega University, Nekemte, Oromia, Ethiopia. FAU - Desalegn, Markos AU - Desalegn M AD - School of Public Health, Wollega University, Nekemte, Oromia, Ethiopia. FAU - Merdassa, Emiru AU - Merdassa E AD - School of Public Health, Wollega University, Nekemte, Oromia, Ethiopia. LA - eng PT - Journal Article DEP - 20260406 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Lesotho/epidemiology MH - Humans MH - Infant MH - *Growth Disorders/epidemiology MH - Child, Preschool MH - Male MH - Female MH - Health Surveys MH - Infant, Newborn MH - Prevalence MH - Multilevel Analysis PMC - PMC13052845 COIS- The authors have declared that no competing interests exist. EDAT- 2026/04/06 18:33 MHDA- 2026/04/06 18:34 PMCR- 2026/04/06 CRDT- 2026/04/06 13:33 PHST- 2025/08/05 00:00 [received] PHST- 2026/01/17 00:00 [accepted] PHST- 2026/04/06 18:34 [medline] PHST- 2026/04/06 18:33 [pubmed] PHST- 2026/04/06 13:33 [entrez] PHST- 2026/04/06 00:00 [pmc-release] AID - PONE-D-25-42093 [pii] AID - 10.1371/journal.pone.0342073 [doi] PST - epublish SO - PLoS One. 2026 Apr 6;21(4):e0342073. doi: 10.1371/journal.pone.0342073. eCollection 2026. PMID- 41939504 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1986-5961 (Electronic) IS - 0350-199X (Print) IS - 0350-199X (Linking) VI - 80 IP - 1 DP - 2026 TI - Predictors of a Depression Indicator in a Large Public Dataset: Logistic Regression and Neural Network Comparison. PG - 63-67 LID - 10.5455/medarh.2026.80.63-67 [doi] AB - BACKGROUND: Depression ranks among the five leading disability causes. The research associations with depression include many demographic, lifestyle and health-related measures. These factors and depression probably interact with each other. OBJECTIVES: The objectives of the study are to describe the characteristics of the participants, to examine the bivariate association between a proxy of depression and the study variables, to identify independent predictors with the help of a logistic regression model, and to evaluate a neural network classification model. METHODS: A cross-sectional secondary analysis of a publicly available dataset N = 50000 was conducted. Depression indicator (Yes/No) is outcome variable. A neural network of the multilayer perceptron type (15 inputs, a hidden layer with. RESULTS: Depression indicator in 40.7% of participants. In bivariable analyses, physical activity, alcohol consumption, dietary habits, family history of depression, and chronic medical conditions showed statistically significant but small differences. Income (p = 0.239) and number of children (p = 0.078) did not differ between groups. CONCLUSION: There was a modest association with depression index and poor discrimination by neural networks. In performing a classification relating to depression using machine learning one must use assessments with validated outcomes and employ class-sensitive performance assessment. CI - (c) 2026 Ibrahim Abdul Jaleel Yamani, Izzeldeen Abdullah Alnaimi, Ahed J. Alkhatib. FAU - Yamani, Ibrahim Abdul Jaleel AU - Yamani IAJ AD - Department of Psychology, College of Social Sciences, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia. AD - Department of Legal Medicine, Toxicology and Forensic Medicine, Jordan University of Science and Technology (retired). Amman, Jordan. FAU - Alnaimi, Izzeldeen Abdullah AU - Alnaimi IA AD - Department of Psychology, College of Social Sciences, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia. AD - Department of Legal Medicine, Toxicology and Forensic Medicine, Jordan University of Science and Technology (retired). Amman, Jordan. FAU - Alkhatib, Ahed J AU - Alkhatib AJ AD - Department of Psychology, College of Social Sciences, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia. AD - Department of Legal Medicine, Toxicology and Forensic Medicine, Jordan University of Science and Technology (retired). Amman, Jordan. LA - eng PT - Journal Article PL - Bosnia and Herzegovina TA - Med Arch JT - Medical archives (Sarajevo, Bosnia and Herzegovina) JID - 101635337 SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Depression/epidemiology/diagnosis MH - Logistic Models MH - *Neural Networks, Computer MH - Female MH - Male MH - Multilayer Perceptrons MH - Adult MH - Classification Algorithms MH - Predictive Learning Models MH - Prediction Algorithms MH - Life Style MH - Secondary Data Analysis MH - Risk Factors PMC - PMC13049475 OTO - NOTNLM OT - Classification performance OT - Depression OT - Lifestyle factors OT - Logistic regression OT - Neural network COIS- The authors declare no conflict of interest. EDAT- 2026/04/06 12:36 MHDA- 2026/04/06 12:37 PMCR- 2026/01/01 CRDT- 2026/04/06 06:18 PHST- 2026/01/29 00:00 [received] PHST- 2026/02/25 00:00 [accepted] PHST- 2026/04/06 12:37 [medline] PHST- 2026/04/06 12:36 [pubmed] PHST- 2026/04/06 06:18 [entrez] PHST- 2026/01/01 00:00 [pmc-release] AID - medarch-80-1-63 [pii] AID - 10.5455/medarh.2026.80.63-67 [doi] PST - ppublish SO - Med Arch. 2026;80(1):63-67. doi: 10.5455/medarh.2026.80.63-67. PMID- 41938021 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260406 LR - 20260813 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - Advancing physical literacy measurement in early childhood: psychometric properties of a novel assessment and profiling method and its relationship with physical activity. PG - 1773645 LID - 10.3389/fspor.2026.1773645 [doi] LID - 1773645 AB - INTRODUCTION: Physical literacy provides a compelling framework for understanding young children's skills, attitudes, and behaviours in relation to movement and physical activity. Assessment represents a crucial step for establishing conceptual and practical relevance. However, there is limited evidence to support how this multidimensional construct can be meaningfully assessed in early childhood, constraining both research advancement and applied intervention. METHODS: This mixed-methods study primarily aims to establish evidence for the Physical Literacy Early Years (PLEY) Wheel, a novel assessment approach assessing physical, social, cognitive, and affective skills and behaviours in children aged 3-5 years. 234 children (74% White British; age 3.84 +/- 0.70 years; 51% girls, IMD decile 3.70 +/- 3.0) and 17 educators (88% female) from 15 early education settings participated across a multi-phase study design. Secondary analyses examine associations with key variables, including device-based measured physical activity, and explore profile-based representations to support interpretation. RESULTS: The PLEY Wheel provides a valid, reliable, and practical approach to benchmarking and profiling physical literacy in early childhood. The results showed that physical literacy increased with age, with girls scoring higher in cognitive and social domains, and children with special education needs or disabilities demonstrating lower physical literacy and physical activity. Physical activity varied widely within and between early education settings and was associated with physical literacy. Five profiles were identified, based on domain strengths and weaknesses, that were sensitive to age, sex, and socio-economic context, but did not strongly differentiate physical activity levels. DISCUSSION: These findings advance the understanding of physical activity and physical literacy in 3-5-year-old children and highlight the potential of a child-centred, data-led approach. Establishing a valid and reliable assessment tool for early childhood provides a methodological foundation for examining how physical literacy manifests, relates to physical activity, and can be meaningfully interpreted to support early intervention. CI - (c) 2026 Weir, Tyler, Pringle and Roscoe. FAU - Weir, Natalie AU - Weir N AD - Clinical Exercise Rehabilitation Research Centre, School of Sport and Exercise Science, University of Derby, Derby, United Kingdom. FAU - Tyler, Richard AU - Tyler R AD - Sport, Physical Activity, Health, and Wellbeing Research Group, International Centre for Applied Research with Children, Young People, Pregnant Women and Families (iCARE), Department of Sport and Physical Activity, Edge Hill University, Ormskirk, United Kingdom. FAU - Pringle, Andy AU - Pringle A AD - Clinical Exercise Rehabilitation Research Centre, School of Sport and Exercise Science, University of Derby, Derby, United Kingdom. FAU - Roscoe, Clare M P AU - Roscoe CMP AD - Clinical Exercise Rehabilitation Research Centre, School of Sport and Exercise Science, University of Derby, Derby, United Kingdom. LA - eng PT - Journal Article DEP - 20260319 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13044117 OTO - NOTNLM OT - assessment OT - early years OT - education OT - physical activity OT - physical literacy OT - pre-school OT - psychometrics COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/06 12:36 MHDA- 2026/04/06 12:37 PMCR- 2026/03/19 CRDT- 2026/04/06 06:06 PHST- 2025/12/22 00:00 [received] PHST- 2026/02/09 00:00 [revised] PHST- 2026/02/17 00:00 [accepted] PHST- 2026/04/06 12:37 [medline] PHST- 2026/04/06 12:36 [pubmed] PHST- 2026/04/06 06:06 [entrez] PHST- 2026/03/19 00:00 [pmc-release] AID - 10.3389/fspor.2026.1773645 [doi] PST - epublish SO - Front Sports Act Living. 2026 Mar 19;8:1773645. doi: 10.3389/fspor.2026.1773645. eCollection 2026. PMID- 41937997 OWN - NLM STAT- In-Process DCOM- 20260406 LR - 20260813 IS - 2352-0132 (Electronic) IS - 2096-6296 (Print) IS - 2352-0132 (Linking) VI - 13 IP - 2 DP - 2026 Mar TI - Effects of family-based nursing interventions on mothers' knowledge, attitudes, and self-efficacy related to stunting prevention in Indonesia: A quasi-experimental study. PG - 113-121 LID - 10.1016/j.ijnss.2026.02.008 [doi] AB - OBJECTIVES: This study aimed to evaluate the effectiveness of family-based nursing interventions in improving mothers' knowledge, attitudes, and self-efficacy to prevent stunting among children under 2 years of age in Indonesia. METHODS: A quasi-experimental study was conducted from June to December 2024 in Alor District, East Nusa Tenggara, Indonesia. Sixty mothers of children aged 0-24 months were recruited using convenience sampling and assigned to either an intervention group (n = 30) or a control group (n = 30). The intervention group received seven structured sessions of a family-based nursing intervention grounded in Family-Centered Care and Social Cognitive Theory. In contrast, the control group received routine health education from local community health centers. Knowledge, attitudes, and self-efficacy were measured using validated questionnaires at baseline, post-intervention, and a three-month follow-up. Data were analyzed using independent-sample t-tests and a mixed repeated-measures analysis of variance. RESULTS: All 60 participants completed the study. Independent-sample t-tests revealed no significant differences between the two groups at baseline for knowledge (t = -0.682, P = 0.498), attitudes (t = 0.655, P = 0.515), and self-efficacy (t = 1.671, P = 0.100). A mixed repeated-measures analysis of variance demonstrated significant group, time, and group x time effects on knowledge, attitudes, and self-efficacy (all P < 0.001). Pairwise comparison revealed that the scores at post-intervention and three-month follow-up were significantly higher in the intervention group for all three variables (all P < 0.001). CONCLUSIONS: The family-based nursing intervention effectively enhanced maternal knowledge, attitudes, and self-efficacy regarding stunting prevention. These findings underscore the importance of incorporating structured, family-centered interventions into community-based public health programs to reduce the risk of stunting. CI - (c) 2026 The Authors. FAU - Setiawan, Agus AU - Setiawan A AD - Department of Community Health Nursing, Faculty of Nursing, Universitas Indonesia, Depok, Indonesia. FAU - Syamsir, Syamikar Baridwan AU - Syamsir SB AD - Department of Nursing, Faculty of Health Sciences, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia. FAU - Rahmadiyah, Dwi Cahya AU - Rahmadiyah DC AD - Department of Community Health Nursing, Faculty of Nursing, Universitas Indonesia, Depok, Indonesia. FAU - Astuti AU - Astuti AD - Department of Pediatric Nursing, Faculty of Nursing, Universitas Indonesia, Depok, Indonesia. FAU - Atamou, Lasarus AU - Atamou L AD - Department of Community Health Nursing, Faculty of Nursing, Universitas Indonesia, Depok, Indonesia. FAU - Talilah, Randy AU - Talilah R AD - Department of Community Health Nursing, Faculty of Nursing, Universitas Indonesia, Depok, Indonesia. FAU - Shorey, Shefaly AU - Shorey S AD - Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Pasir Panjang, Singapore. LA - eng PT - Journal Article DEP - 20260209 PL - China TA - Int J Nurs Sci JT - International journal of nursing sciences JID - 101660887 PMC - PMC13044360 OTO - NOTNLM OT - Attitudes OT - Family nursing OT - Indonesia OT - Knowledge OT - Self-efficacy OT - Stunting COIS- The authors have declared no conflicts of interest. EDAT- 2026/04/06 12:36 MHDA- 2026/04/06 12:37 PMCR- 2026/02/09 CRDT- 2026/04/06 06:06 PHST- 2025/04/28 00:00 [received] PHST- 2026/01/29 00:00 [revised] PHST- 2026/02/09 00:00 [accepted] PHST- 2026/04/06 12:37 [medline] PHST- 2026/04/06 12:36 [pubmed] PHST- 2026/04/06 06:06 [entrez] PHST- 2026/02/09 00:00 [pmc-release] AID - S2352-0132(26)00024-4 [pii] AID - 10.1016/j.ijnss.2026.02.008 [doi] PST - epublish SO - Int J Nurs Sci. 2026 Feb 9;13(2):113-121. doi: 10.1016/j.ijnss.2026.02.008. eCollection 2026 Mar. PMID- 41937899 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260406 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Preoperative nutritional risk and adverse perioperative outcomes in children with congenital choledochal cysts: a retrospective cohort study. PG - 1773325 LID - 10.3389/fped.2026.1773325 [doi] LID - 1773325 AB - BACKGROUND: Congenital choledochal cysts (CCC) are rare biliary anomalies associated with significant morbidity. The impact of preoperative nutritional status on surgical outcomes in pediatric CCC patients remains unclear. This study aimed to investigate this relationship, using a validated nutritional risk screening tool to stratify patients. METHODS: We conducted a retrospective cohort study of pediatric patients who underwent CCC excision with Roux-en-Y hepaticojejunostomy at a single center between January 2011 and September 2025. Nutritional risk was assessed within 24 h of admission using the Screening Tool for Risk on Nutritional Status and Growth (STRONG(kids)). Patients were categorized into moderate malnutrition risk group (MR) and high malnutrition risk group (HR). Propensity score matching (PSM) was employed to balance baseline characteristics. Perioperative outcomes were compared between groups. RESULTS: Among 208 included patients, 107 were stratified as HR and 101 as MR before PSM. After PSM, 91 matched pairs were analyzed. The HR group had significantly lower weight-for-age (WAZ), height-for-age (HAZ), and BMI-for-age z-scores (BAZ), along with lower preoperative hemoglobin, albumin, total protein, and higher bilirubin and GGT levels. Postoperatively, the HR group experienced longer abdominal drainage duration, delayed gastrointestinal recovery, higher inflammatory markers (WBC, CRP), worse liver function markers, and lower albumin and lymphocyte counts. The overall complication rate was significantly higher in the HR group, primarily driven by a greater incidence of cholangitis. CONCLUSION: Preoperative high nutritional risk, identified by the STRONG(kids) screening tool, is strongly associated with adverse perioperative outcomes in children undergoing CCC surgery. Routine nutritional screening may facilitate risk stratification and guide preoperative optimization. CI - (c) 2026 Liu, Wang, Li, Zhang, Han, Sun, Xu, Ren, Wang, Wang and Li. FAU - Liu, Xiaoyang AU - Liu X AD - Department of Pediatric Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China. FAU - Wang, Yixuan AU - Wang Y AD - Department of Pediatric Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China. FAU - Li, Jiamin AU - Li J AD - Department of Pediatric Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China. FAU - Zhang, Yujie AU - Zhang Y AD - Department of Pediatric Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China. FAU - Han, Jichang AU - Han J AD - Department of Pediatric Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China. FAU - Sun, Dong AU - Sun D AD - Department of Pediatric Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China. FAU - Xu, Qiongqian AU - Xu Q AD - Department of Pediatric Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China. FAU - Ren, Xue AU - Ren X AD - Department of Pediatric Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China. FAU - Wang, Dongming AU - Wang D AD - Department of Pediatric Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China. FAU - Wang, Jian AU - Wang J AD - Department of Pediatric Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China. FAU - Li, Aiwu AU - Li A AD - Department of Pediatric Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China. LA - eng PT - Journal Article DEP - 20260320 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13046502 OTO - NOTNLM OT - STRONGkids OT - children OT - congenital choledochal cyst OT - nutritional risk OT - perioperative outcomes COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/06 12:35 MHDA- 2026/04/06 12:36 PMCR- 2026/03/20 CRDT- 2026/04/06 06:05 PHST- 2026/01/14 00:00 [received] PHST- 2026/02/19 00:00 [revised] PHST- 2026/02/27 00:00 [accepted] PHST- 2026/04/06 12:36 [medline] PHST- 2026/04/06 12:35 [pubmed] PHST- 2026/04/06 06:05 [entrez] PHST- 2026/03/20 00:00 [pmc-release] AID - 10.3389/fped.2026.1773325 [doi] PST - epublish SO - Front Pediatr. 2026 Mar 20;14:1773325. doi: 10.3389/fped.2026.1773325. eCollection 2026. PMID- 41937509 OWN - NLM STAT- MEDLINE DCOM- 20260609 LR - 20260813 IS - 1536-4801 (Electronic) IS - 0277-2116 (Print) IS - 0277-2116 (Linking) VI - 82 IP - 6 DP - 2026 Jun TI - Longitudinal performance of vibration controlled transient elastography in pediatric metabolic dysfunction associated steatotic liver disease. PG - 1366-1372 LID - 10.1002/jpn3.70423 [doi] AB - OBJECTIVES: Vibration controlled transient elastography (VCTE) is increasingly used to monitor metabolic dysfunction-associated steatotic liver disease (MASLD), yet optimal interpretation of serial controlled attenuation parameter (CAP) and liver stiffness measurements (LSMs) in children is undefined. We aimed to characterize longitudinal trends in CAP and LSM and assess whether changes in these measures reflect validated measures of disease regression or progression. METHODS: Longitudinal retrospective study of youth with MASLD who underwent >/=2 VCTE studies. Disease regression and progression were defined using categorical and continuous changes in alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) previously linked to histologic improvement or worsening. Spaghetti plots illustrated trends over time, while longitudinal linear mixed-effects models and proportional odds mixed models assessed associations between CAP, LSM, and liver enzyme outcomes. RESULTS: The cohort included 149 children (72% male, 43% Hispanic) with a mean age of 14 +/- 4 years and a mean follow-up of 1.4 years. CAP and LSM showed marked intraindividual variability. Independent predictors of CAP change included age, body mass index (BMI) percentile, and glycated hemoglobin (HbA1c); predictors of LSM change included ALT, BMI, and HbA1c. Changes in CAP and LSM did not predict categorical outcomes of ALT and GGT reduction, however were significantly positively associated with continuous ALT and GGT outcomes, independent of BMI percentile. CONCLUSIONS: Longitudinal VCTE in pediatric MASLD has the potential to identify disease progression. The intraindividual variability of CAP and LSM may limit the ability to detect short-term regression or progression, highlighting the need for more precise noninvasive biomarkers for pediatric MASLD. CI - (c) 2026 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Diop-West, Naima AU - Diop-West N AD - Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. FAU - Denson, Nicholas AU - Denson N AD - Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. FAU - Arce-Clachar, Ana Catalina AU - Arce-Clachar AC AD - Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. AD - University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. FAU - Bonn, Julie AU - Bonn J AD - Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. AD - University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. FAU - Bramlage, Kristin AU - Bramlage K AD - Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. FAU - Leesman, Lisa AU - Leesman L AD - Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. FAU - Sahay, Rashmi D AU - Sahay RD AD - Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. FAU - Gecili, Emrah AU - Gecili E AD - University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. AD - Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. FAU - Trout, Andrew T AU - Trout AT AD - University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. AD - Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. FAU - Xanthakos, Stavra AU - Xanthakos S AD - Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. AD - University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. FAU - Mouzaki, Marialena AU - Mouzaki M AUID- ORCID: 0000-0002-9809-6199 AD - Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. AD - University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. LA - eng GR - P30 DK078392/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20260406 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 RN - EC 2.3.2.2 (gamma-Glutamyltransferase) RN - EC 2.6.1.2 (Alanine Transaminase) SB - IM MH - Humans MH - *Elasticity Imaging Techniques/methods MH - Male MH - Longitudinal Studies MH - Female MH - Retrospective Studies MH - Child MH - Adolescent MH - Disease Progression MH - Vibration MH - *Liver/diagnostic imaging/pathology MH - *Fatty Liver/diagnostic imaging MH - gamma-Glutamyltransferase/blood MH - Alanine Transaminase/blood PMC - PMC13344883 MID - NIHMS2182512 OTO - NOTNLM OT - FibroScan OT - children OT - fatty liver OT - outcome COIS- Conflicts of interest and sources of funding: No conflicts. This work was supported by NIH grant P30 DK078392 (Clinical Component) of the Digestive Diseases Research Core Center in Cincinnati EDAT- 2026/04/06 06:30 MHDA- 2026/06/10 06:53 PMCR- 2026/07/08 CRDT- 2026/04/06 03:32 PHST- 2026/01/22 00:00 [revised] PHST- 2025/10/28 00:00 [received] PHST- 2026/02/18 00:00 [accepted] PHST- 2026/06/10 06:53 [medline] PHST- 2026/04/06 06:30 [pubmed] PHST- 2026/04/06 03:32 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - 10.1002/jpn3.70423 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2026 Jun;82(6):1366-1372. doi: 10.1002/jpn3.70423. Epub 2026 Apr 6. PMID- 41937219 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260520 LR - 20260813 IS - 2055-5784 (Print) IS - 2055-5784 (Electronic) IS - 2055-5784 (Linking) VI - 12 IP - 1 DP - 2026 Apr 6 TI - A machine learning approach to using ultrasound for body composition and nutritional status assessment in newborns: a pilot study protocol. LID - 10.1186/s40814-026-01814-w [doi] LID - 74 AB - BACKGROUND: Accurate assessment of infant body composition, specifically fat and fat-free mass, is crucial for evaluating growth and nutritional status. Existing methods, such as air displacement plethysmography and dual-energy X-ray absorptiometry, are expensive, require specialized facilities, and demand trained personnel. Ultrasound offers a promising alternative as a portable, low-cost tool capable of distinguishing adipose tissue from skeletal muscle. However, its feasibility for widespread use in diverse clinical settings remains uncertain. This pilot study aims to assess the feasibility, acceptability, and reliability of an ultrasound scanning protocol for measuring body composition in infants while establishing a foundation for artificial intelligence (AI)-enabled analysis to enable whole-body composition estimation from ultrasound images. METHODS: We will recruit 50 infants (20 preterm and 30 full-term infants) from two sites: Brigham and Women's Hospital (Boston, MA, USA) and Jimma Medical Center (Jimma, Ethiopia). Feasibility will be assessed through metrics such as recruitment rates, scan completion, and session duration. Acceptability will be measured using clinician feedback, and reliability will be evaluated using intra-class correlation coefficients (ICCs) for ultrasound image acquisition. A comprehensive database of ultrasound images and corresponding body composition metrics will be developed, forming the foundation for training AI models. Preliminary machine learning (ML) models, including convolutional neural networks (CNN), will be developed to predict body composition. The accuracy of these models will be evaluated using metrics such as root mean squared error (RMSE), mean absolute percent error (MAPE), mean absolute error (MAE), and mean squared error (MSE). DISCUSSION: This study will determine the feasibility of integrating ultrasound-based body composition assessment into neonatal clinical workflows as a potential future application. We will evaluate protocol adherence, scan reliability, and clinician and family acceptability to guide further protocol optimization. Findings will inform the design of a larger-scale study and contribute to refining AI models for clinical use. Ultimately, this approach aims to improve the accessibility, accuracy, and efficiency of body composition assessments, particularly in low-resource settings, where it could enable frontline healthcare workers to perform these assessments without specialized training, improving care for vulnerable infants. CI - (c) 2026. The Author(s). FAU - Ranger, Bryan J AU - Ranger BJ AUID- ORCID: 0000-0002-4774-3587 AD - Department of Engineering, Boston College, Chestnut Hill, MA, 02467, USA. bryan.ranger@bc.edu. AD - William F. Connell School of Nursing, Boston College, Chestnut Hill, MA, USA. bryan.ranger@bc.edu. FAU - Albert, Marisa AU - Albert M AD - William F. Connell School of Nursing, Boston College, Chestnut Hill, MA, USA. FAU - Kim, Ji In AU - Kim JI AD - William F. Connell School of Nursing, Boston College, Chestnut Hill, MA, USA. FAU - Cho, Hayoung AU - Cho H AD - Department of Engineering, Boston College, Chestnut Hill, MA, 02467, USA. FAU - Hohenberg, Julie AU - Hohenberg J AD - Department of Computer Science, Boston College, Chestnut Hill, MA, USA. FAU - He, Keshi AU - He K AD - Department of Engineering, Boston College, Chestnut Hill, MA, 02467, USA. FAU - Wei, Donglai AU - Wei D AD - Department of Computer Science, Boston College, Chestnut Hill, MA, USA. FAU - Berhane, Melkamu AU - Berhane M AD - Department of Pediatrics and Child Health, Jimma University, Jimma, Ethiopia. FAU - Girma, Tsinuel AU - Girma T AD - Department of Pediatrics and Child Health, Jimma University, Jimma, Ethiopia. FAU - Estroff, Judy AU - Estroff J AD - Department of Radiology, Boston Children's Hospital, Boston, MA, USA. AD - Harvard Medical School, Boston, MA, USA. FAU - Bell, Katherine A AU - Bell KA AD - Harvard Medical School, Boston, MA, USA. AD - Department of Pediatrics, Brigham & Women's Hospital, Boston, MA, USA. FAU - Park, Jinhee AU - Park J AD - William F. Connell School of Nursing, Boston College, Chestnut Hill, MA, USA. LA - eng PT - Journal Article DEP - 20260406 PL - England TA - Pilot Feasibility Stud JT - Pilot and feasibility studies JID - 101676536 PMC - PMC13188397 OTO - NOTNLM OT - Body composition OT - Malnutrition OT - Newborn and child health OT - Nutritional assessment OT - Pediatrics OT - Ultrasound COIS- Declarations. Ethics approval and consent to participate: Ethical approval has been obtained from the Institutional Review Boards (IRBs) of Boston College, Mass General Brigham (protocol #2023P000325), and Jimma University, as well as the Ethiopian Ministry of Education National Research Ethics Review Committee (protocol #17/242/731/23) to safeguard participant rights throughout the study. Written informed consent will be obtained from the parents or legal guardians of all participants prior to enrollment in the study. All data will be collected and handled in accordance with ethical guidelines to ensure participant confidentiality throughout the study. Consent for publication: Not applicable. The manuscript does not contain individual person's data in any form, including details, images or videos. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/04/06 00:31 MHDA- 2026/04/06 00:32 PMCR- 2026/04/06 CRDT- 2026/04/05 23:45 PHST- 2024/11/22 00:00 [received] PHST- 2026/03/22 00:00 [accepted] PHST- 2026/04/06 00:32 [medline] PHST- 2026/04/06 00:31 [pubmed] PHST- 2026/04/05 23:45 [entrez] PHST- 2026/04/06 00:00 [pmc-release] AID - 10.1186/s40814-026-01814-w [pii] AID - 1814 [pii] AID - 10.1186/s40814-026-01814-w [doi] PST - epublish SO - Pilot Feasibility Stud. 2026 Apr 6;12(1):74. doi: 10.1186/s40814-026-01814-w. PMID- 41935198 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Apr 4 TI - Application of machine learning algorithm for predicting acute malnutrition among under 5 children in east Africa using recent DHS. LID - 10.1038/s41598-026-46944-6 [doi] LID - 16242 AB - Acute malnutrition remains a critical public health challenge across East Africa, contributing substantially to under-five morbidity and mortality. Early identification of at-risk children using predictive models could enhance timely intervention. This study aimed to develop and evaluate machine learning models for predicting acute malnutrition among under-five children in East Africa. A cross-sectional analysis was conducted using the most recent DHS data from 12 East African countries. A total of 76,224 children under-five years were included. Data preprocessing involved multiple imputation for missing values, one-hot encoding for categorical variables, SMOTE to address class imbalance, and multiple feature selection. ten supervised machine learning algorithms; Logistic Regression, Random Forest, K-Nearest Neighbors, Decision Tree, Support Vector Machine, Naive Bayes, XGBoost, LightGBM, CatBoost, and Stochastic Gradient Descent were trained and evaluated using an 80/20 train-test split and stratified five-fold cross-validation. Model performance was assessed using accuracy, AUC, precision, recall, and F1-score, and interpretability was explored using SHapley Additive exPlanations (SHAP). The overall prevalence of acute malnutrition across east Africa was 6.08% (95% CI 5.91-6.25%), ranging from 1.2% in Rwanda to 12.27% in Ethiopia. The Random Forest algorithm demonstrated the best predictive performance, achieving an AUC of 74.6% (95% CI 73.0-76.2), accuracy of 71.2%, precision of 13.1%, recall of 66.2%, specificity of 71.5%, and an F1-score of 0.218. SHAP analysis identified important predictors of acute malnutrition as rural residence, large family size (>/= 6 members), higher number of under-five children (>/= 3), small or very small birth size, inadequate antenatal care, unimproved water sources, inappropriate disposal of child feces, recent diarrheal illness, and lack of latrine facilities. Protective factors included maternal literacy, antenatal care attendance, vitamin A supplementation, longer birth intervals (>/= 2 years), and maternal employment. Random Forest, demonstrate superior predictive capacity for identifying children at risk of acute malnutrition in East Africa. The integration of such models into national nutrition surveillance systems could enable early detection and targeted interventions. Strategies should prioritize rural communities, strengthen maternal education and empowerment, improve water and sanitation infrastructure, and antenatal care to mitigate risk factors and enhance child nutritional outcomes. CI - (c) 2026. The Author(s). FAU - Feleke, Habtamu Guaguahu AU - Feleke HG AD - Department of Public Health, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia. guaguahuhabtamu@gmail.com. FAU - Simegn, Mulat Belay AU - Simegn MB AD - Department of Public Health, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia. FAU - Gebreegziabher, Zenebe Abebe AU - Gebreegziabher ZA AD - Department of Epidemiology and Biostatistics, School of Public Health, Asrat Woldeyes Health Sciences Campus, Debre Berhan University, Debre Berhan, Ethiopia. FAU - Mazengia, Elyas Melaku AU - Mazengia EM AD - Department of Public Health, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia. FAU - Tilahun, Werkneh Melkie AU - Tilahun WM AD - Department of Public Health, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia. LA - eng PT - Journal Article DEP - 20260404 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Africa, Eastern/epidemiology MH - *Machine Learning MH - Child, Preschool MH - Female MH - Boosting Machine Learning Algorithms MH - Predictive Learning Models MH - *Malnutrition/epidemiology/diagnosis MH - Classification Algorithms MH - Random Forest MH - Male MH - Prediction Algorithms MH - Cross-Sectional Studies MH - Infant MH - Algorithms MH - East African People MH - Prevalence MH - Logistic Models PMC - PMC13201603 OTO - NOTNLM OT - Acute malnutrition OT - Children OT - East Africa OT - Machine learning OT - Prediction COIS- Declarations. Ethical approval: The Study was a secondary data analysis based on publicly accessible DHS database and after we asked the MEASURE DHS Program for the data, and we were given permission to download and utilize it. All analyses were conducted in compliance with the DHS data use guidelines to maintain the privacy and rights of the survey participants. The consents are available at https://www.dhsprogram.com/methodology/Protecting-the-Privacy-of-DHS-Survey-Respondents.cfm . Competing interests: The authors declare no competing interests. EDAT- 2026/04/05 04:22 MHDA- 2026/05/26 00:31 PMCR- 2026/04/04 CRDT- 2026/04/04 23:17 PHST- 2025/11/14 00:00 [received] PHST- 2026/03/28 00:00 [accepted] PHST- 2026/05/26 00:31 [medline] PHST- 2026/04/05 04:22 [pubmed] PHST- 2026/04/04 23:17 [entrez] PHST- 2026/04/04 00:00 [pmc-release] AID - 10.1038/s41598-026-46944-6 [pii] AID - 46944 [pii] AID - 10.1038/s41598-026-46944-6 [doi] PST - epublish SO - Sci Rep. 2026 Apr 4;16(1):16242. doi: 10.1038/s41598-026-46944-6. PMID- 41933946 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260803 IS - 1878-1861 (Electronic) IS - 1878-1861 (Linking) VI - 29 IP - 9 DP - 2026 Aug TI - Development of a machine learning model to detect toddlers' physical activity and sedentary time using accelerometers: Little Movers Activity Analysis. PG - 1015-1023 LID - S1440-2440(26)00103-9 [pii] LID - 10.1016/j.jsams.2026.03.009 [doi] AB - OBJECTIVES: Toddler movement patterns challenge current accelerometer-based detection of physical activity (PA) and sedentary time (SED). The objectives of this study were to: (1) develop a novel machine learning (ML) model to detect toddlers' PA and SED; and (2) compare this ML model to existing cut-point methods to analyze toddlers' PA (independent sample cross-validation of existing methods). DESIGN AND METHODS: We recruited 111 toddlers (21 +/- 7 months; 51% female) to two 1-hour semi-structured visits wearing a waist-worn ActiGraph wGT3X-BT accelerometer. Video recordings were manually annotated using a modified Children's Activity Rating Scale to determine a ground truth. We extracted 40 time and frequency domain features from raw accelerations and trained 4 gradient boosted tree ML models (distinguishing SED, total PA (TPA), light PA (LPA), moderate-to-vigorous PA (MVPA), and non-volitional movement (NVM)). Models were assessed using accuracy, F1 scores, and confusion matrices. For the validation of 11 existing methods, we calculated accuracy, F1, and mean absolute differences in TPA and MVPA estimation. RESULTS: ML models classifying NVM/SED/TPA and NVM/SED/LPA/MVPA reached 82% and 74% accuracy with mean absolute differences of 3.0 and 3.2 min/h, respectively. Independent sample cross-validation found accuracies from 33 to 74% and mean absolute differences from 7.6 to 18.6 min/h in TPA and 10.7 to 25.8 min/h in MVPA. CONCLUSIONS: We recommend the NVM/SED/TPA or NVM/SED/LPA/MVPA models' given alignment with toddler TPA guidelines and MVPA link to health outcomes, respectively. We additionally present an open-access interface for using these ML models that does not require coding knowledge. This presents a substantial step forward in the measurement of toddlers' physical activity. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Letts, Elyse AU - Letts E AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Canada. FAU - King-Dowling, Sara AU - King-Dowling S AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Canada; Department of Pediatrics, The Children's Hospital of Philadelphia, United States of America. FAU - Di Cristofaro, Natascja AU - Di Cristofaro N AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Canada. FAU - Tucker, Patricia AU - Tucker P AD - School of Occupational Therapy, Western University, Canada; Children's Health Research Institute, Canada. FAU - Cairney, John AU - Cairney J AD - School of Human Movement and Nutrition Sciences, Health and Well-Being Centre for Research Innovation, Queensland Centre for Olympic and Paralympic Studies, University of Queensland, Australia. FAU - Kobsar, Dylan AU - Kobsar D AD - Department of Kinesiology, Faculty of Science, McMaster University, Canada. FAU - Timmons, Brian W AU - Timmons BW AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Canada; Department of Kinesiology, Faculty of Science, McMaster University, Canada. FAU - Obeid, Joyce AU - Obeid J AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Canada; Department of Kinesiology, Faculty of Science, McMaster University, Canada. Electronic address: obeidj@mcmaster.ca. LA - eng PT - Journal Article DEP - 20260318 PL - Australia TA - J Sci Med Sport JT - Journal of science and medicine in sport JID - 9812598 SB - IM MH - Humans MH - *Sedentary Behavior MH - Female MH - *Accelerometry/methods MH - *Machine Learning MH - Infant MH - *Exercise MH - Child, Preschool MH - Male MH - Predictive Learning Models MH - Boosting Machine Learning Algorithms OTO - NOTNLM OT - Accelerometry OT - Actigraphy OT - Early years OT - Gradient boosted trees OT - Sedentary behavior OT - Trees COIS- Declaration of interest statement None. The authors declare no conflicts of interest. EDAT- 2026/04/04 06:33 MHDA- 2026/08/04 00:35 CRDT- 2026/04/04 02:10 PHST- 2025/10/01 00:00 [received] PHST- 2026/01/15 00:00 [revised] PHST- 2026/03/13 00:00 [accepted] PHST- 2026/08/04 00:35 [medline] PHST- 2026/04/04 06:33 [pubmed] PHST- 2026/04/04 02:10 [entrez] AID - S1440-2440(26)00103-9 [pii] AID - 10.1016/j.jsams.2026.03.009 [doi] PST - ppublish SO - J Sci Med Sport. 2026 Aug;29(9):1015-1023. doi: 10.1016/j.jsams.2026.03.009. Epub 2026 Mar 18. PMID- 41933386 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1750-1172 (Electronic) IS - 1750-1172 (Linking) VI - 21 IP - 1 DP - 2026 Apr 3 TI - Attenuated dietary motivation in Wilson's disease correlates with clinical severity. LID - 10.1186/s13023-026-04263-z [doi] LID - 130 AB - BACKGROUND & AIMS: Wilson's disease (WD) necessitates lifelong copper-chelation therapy and a restrictive low-copper diet. While the psychological impact of dietary restriction is well-documented in obesity and diabetes, the distinctive eating psychology of WD patients remains unexplored. We aimed to characterize the eating psychology of WD patients and its association with disease severity. METHODS: In a cross-sectional study, 50 WD inpatients and 110 HCs were assessed using the Food Cravings Questionnaire-Trait (FCQ-T) and the Dutch Eating Behavior Questionnaire (DEBQ). WD patients were stratified by liver function, neurological symptoms, and platelet-to-white blood cell ratio (PWR), and prevalent ATP7B genotype (R778L). Group comparisons used non-parametric tests. RESULTS: Compared to HCs, WD patients showed significantly lower scores on all DEBQ dimensions and key FCQ-T facets (all p<0.05). Within the WD cohort, patients with milder liver disease (CTP-A) or no neurological symptoms had significantly higher scores on emotion-driven craving and food-related reinforcement than those with advanced disease (CTP-B/C) or neurological involvement (p<0.05). A low PWR, indicative of severe liver fibrosis, was associated with significantly reduced "Thoughts about food" (U=396.5, p=0.028). Exploratory analysis based on the R778L mutation revealed no significant association between genotype and dietary psychological scores. CONCLUSIONS: WD is associated with a generally attenuated dietary motivation; however, patients with less severe disease exhibit a characteristic psychological profile with relatively stronger reward-related eating motivations compared to their more severely affected counterparts. These findings highlight the need for integrated psychometric assessment in WD management to guide personalized dietary interventions and improve outcomes. CI - (c) 2026. The Author(s). FAU - Wang, Xue-Qiao AU - Wang XQ AD - Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, No. 117 Meishan Road, Hefei, Anhui, 230031, China. FAU - Wang, Yan-Xin AU - Wang YX AD - Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, No. 117 Meishan Road, Hefei, Anhui, 230031, China. 2197878957@qq.com. FAU - Ye, Zhao-Hao AU - Ye ZH AD - Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, No. 117 Meishan Road, Hefei, Anhui, 230031, China. FAU - Zhang, Zhi-Lin AU - Zhang ZL AD - Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, No. 117 Meishan Road, Hefei, Anhui, 230031, China. FAU - Pan, Xun AU - Pan X AD - Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, No. 117 Meishan Road, Hefei, Anhui, 230031, China. FAU - Wang, Xi-Chen AU - Wang XC AD - Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, No. 117 Meishan Road, Hefei, Anhui, 230031, China. FAU - Cen, Si-Fan AU - Cen SF AD - Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, No. 117 Meishan Road, Hefei, Anhui, 230031, China. LA - eng PT - Journal Article DEP - 20260403 PL - England TA - Orphanet J Rare Dis JT - Orphanet journal of rare diseases JID - 101266602 SB - IM MH - Humans MH - Female MH - Male MH - *Hepatolenticular Degeneration/psychology/physiopathology/genetics/pathology MH - Adult MH - Cross-Sectional Studies MH - *Motivation/physiology MH - Surveys and Questionnaires MH - Feeding Behavior/physiology MH - Adolescent MH - Young Adult MH - Middle Aged MH - Diet PMC - PMC13049706 OTO - NOTNLM OT - Dutch eating behavior questionnaire OT - Eating psychology OT - Low-copper diet OT - PWR OT - Reward motivation OT - Wilson's disease COIS- Declarations. Ethics approval and consent to participate: The study protocol was approved by the Ethics Committee of The First Affiliated Hospital of Anhui University of Chinese Medicine and was conducted in accordance with the ethical principles of the Declaration of Helsinki. All participants provided written informed consent. Consent for publication: All authors have read and approved the final manuscript and give their consent for publication. Conflict of interest: The first author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Generative AI statement: The first author declares that no Generative AI was used in the creation of this manuscript. EDAT- 2026/04/04 00:36 MHDA- 2026/04/04 06:34 PMCR- 2026/04/03 CRDT- 2026/04/03 23:50 PHST- 2025/10/07 00:00 [received] PHST- 2026/02/05 00:00 [accepted] PHST- 2026/04/04 06:34 [medline] PHST- 2026/04/04 00:36 [pubmed] PHST- 2026/04/03 23:50 [entrez] PHST- 2026/04/03 00:00 [pmc-release] AID - 10.1186/s13023-026-04263-z [pii] AID - 4263 [pii] AID - 10.1186/s13023-026-04263-z [doi] PST - epublish SO - Orphanet J Rare Dis. 2026 Apr 3;21(1):130. doi: 10.1186/s13023-026-04263-z. PMID- 41931948 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260921 IS - 1873-5711 (Electronic) IS - 1050-6411 (Print) IS - 1050-6411 (Linking) VI - 88 DP - 2026 Jun TI - Reliability of bioimpedance spectroscopy in the upper trapezius muscle. PG - 103149 LID - S1050-6411(26)00045-3 [pii] LID - 10.1016/j.jelekin.2026.103149 [doi] AB - OBJECTIVE: Localized bioimpedance spectroscopy (BIS) is a non-invasive technique for assessing muscle tissue properties. This study examined the test-retest reliability of BIS measurements on the upper trapezius muscle and the effects of body positioning and electrode reapplication. APPROACH: Ten healthy adults (ages 18-30) with no history of neck or shoulder pain participated in the study. BIS measurements were collected over two days across three body positions (prone, seated, seated with neck bent) and with different electrode applications. Key impedance parameters were extracted from Cole-Cole plots. We evaluated measurement reliability, variability, and the minimum detectable change. MAIN RESULTS: BIS measures demonstrated high reliability for primary impedance parameters when body positioning was controlled, whereas model-derived parameters showed greater variability. Impedance parameters differed if the participants were seated or lying prone but were not sensitive to bending the neck to the side. Electrode reapplication did not significantly alter measures unless applied a third time, and sex-related differences were not significant. SIGNIFICANCE: BIS appears to be a reliable method for assessing upper trapezius muscle tissue properties when body position is standardized. Future research should explore BIS applications in larger and more diverse populations and evaluate its potential clinical utility. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Lamarre, Morgan A AU - Lamarre MA AD - Department of Bioengineering, George Mason University, Fairfax, VA, United States. FAU - Koduri, Sresta AU - Koduri S AD - Department of Bioengineering, George Mason University, Fairfax, VA, United States. FAU - Akhwand, Reihana A AU - Akhwand RA AD - Department of Bioengineering, George Mason University, Fairfax, VA, United States. FAU - Hsu, Yu-Lin AU - Hsu YL AD - Department of Statistics, George Mason University, Fairfax, VA, United States. FAU - Lee, Seiyon AU - Lee S AD - Department of Statistics, George Mason University, Fairfax, VA, United States; Center for MedTech Innovation, George Mason University, Fairfax, VA, United States. FAU - Rosenberger, William F AU - Rosenberger WF AD - Department of Statistics, George Mason University, Fairfax, VA, United States; Center for MedTech Innovation, George Mason University, Fairfax, VA, United States. FAU - DeStefano, Secili AU - DeStefano S AD - Optimal Motion Physical Therapy, Herndon, VA, United States; Center for MedTech Innovation, George Mason University, Fairfax, VA, United States. FAU - Srbely, John AU - Srbely J AD - Department of Human Health and Nutritional Sciences, University of Guelph, ON, Canada. FAU - Shah, Jay P AU - Shah JP AD - Rehabilitation Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, United States. FAU - Gerber, Lynn H AU - Gerber LH AD - Department of Medicine, INOVA Health System, Fairfax, VA, United States; Center for MedTech Innovation, George Mason University, Fairfax, VA, United States. FAU - Acuna, Samuel A AU - Acuna SA AD - Department of Bioengineering, George Mason University, Fairfax, VA, United States; Center for MedTech Innovation, George Mason University, Fairfax, VA, United States. Electronic address: sacuna2@gmu.edu. FAU - Sikdar, Siddhartha AU - Sikdar S AD - Department of Bioengineering, George Mason University, Fairfax, VA, United States; Center for MedTech Innovation, George Mason University, Fairfax, VA, United States. Electronic address: ssikdar@gmu.edu. LA - eng GR - R61 AT012286/AT/NCCIH NIH HHS/United States PT - Journal Article DEP - 20260328 PL - England TA - J Electromyogr Kinesiol JT - Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology JID - 9109125 SB - IM MH - Humans MH - Female MH - Male MH - Reproducibility of Results MH - *Superficial Back Muscles/physiology MH - Adult MH - Young Adult MH - Sensitivity and Specificity MH - *Dielectric Spectroscopy/methods MH - Adolescent MH - *Muscle Contraction/physiology MH - *Body Composition/physiology PMC - PMC13132660 MID - NIHMS2161100 OTO - NOTNLM OT - Electrical impedance myography OT - Electrode placement OT - Electrophysiology OT - Reliability OT - Tissue properties COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/04 00:35 MHDA- 2026/05/15 03:09 PMCR- 2026/05/01 CRDT- 2026/04/03 18:02 PHST- 2025/11/26 00:00 [received] PHST- 2026/03/24 00:00 [revised] PHST- 2026/03/27 00:00 [accepted] PHST- 2026/05/15 03:09 [medline] PHST- 2026/04/04 00:35 [pubmed] PHST- 2026/04/03 18:02 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - S1050-6411(26)00045-3 [pii] AID - 10.1016/j.jelekin.2026.103149 [doi] PST - ppublish SO - J Electromyogr Kinesiol. 2026 Jun;88:103149. doi: 10.1016/j.jelekin.2026.103149. Epub 2026 Mar 28. PMID- 41931044 OWN - NLM STAT- MEDLINE DCOM- 20261004 LR - 20261016 IS - 2831-090X (Electronic) IS - 2831-0896 (Print) IS - 2831-0896 (Linking) VI - 26 IP - 11 DP - 2026 Apr 2 TI - Prognostic nutritional index predicts 1-year hospitalization and mortality in outpatients with cirrhosis. PG - 2031-2040 LID - 10.17305/bb.2026.14035 [doi] AB - Malnutrition is prevalent in patients with cirrhosis and is linked to negative clinical outcomes. However, research on the prognostic nutritional index (PNI) and the burden of hospitalization over one year in stable outpatients remains limited. This study aimed to assess the relationship between PNI and liver-related hospitalization outcomes, as well as 12-month mortality, in outpatients with cirrhosis. In this retrospective single-center study, 125 adult patients with stable cirrhosis were analyzed, focusing on baseline demographic, clinical, laboratory, and 12-month follow-up data. Logistic regression was employed to evaluate the incidence of hospitalization in the entire cohort, while Poisson regression assessed hospital admission counts among patients with complete follow-up, and linear regression investigated the total length of stay for hospitalized patients.The results indicated that lower PNI values were significantly correlated with an increased likelihood of hospitalization and a higher frequency of hospital admissions within one year. In multivariable analysis, PNI remained an independent predictor of hospitalization (odds ratio [OR] = 0.655, 95% confidence interval [CI]: 0.530-0.809, p < 0.001) and admission frequency (incidence rate ratio [IRR] = 0.90, 95% CI: 0.848-0.955, p < 0.001), while no significant association was found with the length of hospital stay. Each 5-unit increase in PNI corresponded to substantially lower odds of hospitalization (OR = 0.121, 95% CI: 0.042-0.347) and a reduced admission rate (IRR = 0.59, 95% CI: 0.444-0.794). Additionally, PNI exhibited significant negative correlations with the Model for End-Stage Liver Disease-Sodium (MELD-Na) and Child-Turcotte-Pugh scores (all p < 0.001). PNI also demonstrated strong predictive validity for 12-month cirrhosis-related mortality, with an area under the curve (AUC) of 0.873 (95% CI: 0.802-0.943) and an optimal cut-off value of 38.5. Patients with a PNI /=5 indicating symptoms. Potential features included sociodemographic, economic, nutritional, food insecurity, and health-related factors. Ridge Logistic Regression (LR), Random Forest (RF), and Extreme Gradient Boosting (XGBoost) models were applied to predict depressive and anxiety symptoms. Model performance was evaluated using area under the receiver operating characteristic curve (AUC), accuracy, sensitivity, and specificity. Shapley additive explanations values were used for feature selection and interpretation. RESULTS: Among the 1,995 mothers, 15.1% had depressive symptoms, and 8.7% had anxiety symptoms. Model performance was acceptable and comparable across all models. For depression, AUC values for Ridge LR, RF and XGBoost were 0.724 (95% CI: 0.656-0.785), 0.711 (95% CI: 0.642-0.774), and 0.705 (95% CI: 0.628-0.772) respectively. For anxiety, AUCs were 0.788 (95% CI: 0.712-0.857), 0.789 (95% CI: 0.709-0.861), and 0.785 (95% CI: 0.708-0.854), respectively. Increased household food insecurity was the strongest predictor of both conditions. Additional key predictors included low wealth index, lower body mass index, higher number of children, pregnancy complications and advanced maternal age. CONCLUSIONS: Postpartum mental health disorders remain a substantial burden in SSA. This study demonstrates the feasibility of using ML to predict depressive and anxiety symptoms in postpartum mothers. The findings identify key predictors, notably increased household food insecurity, alongside socioeconomic status and maternal health characteristics, that could inform the design and testing of targeted interventions. Future studies should include external validation and examine causal links between these predictors and postpartum mental health outcomes. CI - Copyright (c) 2026 Benson, Odhiambo, Brink, Ngugi, Waljee, Weinheimer-Haus, Moyer, Zhu and Abubakar. FAU - Benson, Faith Neema AU - Benson FN AD - Institute for Human Development, Aga Khan University, Nairobi, Kenya. AD - Department of Mathematical Sciences, Stellenbosch University, Stellenbosch, South Africa. FAU - Odhiambo, Rachel AU - Odhiambo R AD - Institute for Human Development, Aga Khan University, Nairobi, Kenya. FAU - Brink, Willie AU - Brink W AD - Department of Mathematical Sciences, Stellenbosch University, Stellenbosch, South Africa. FAU - Ngugi, Anthony K AU - Ngugi AK AD - Department of Population Health, Medical College, Aga Khan University, Nairobi, Kenya. FAU - Waljee, Akbar K AU - Waljee AK AD - Department of Learning Health Sciences, University of Michigan, Ann Arbor, MI, United States. AD - Center for Global Health Equity, University of Michigan, Ann Arbor, MI, United States. FAU - Weinheimer-Haus, Eileen M AU - Weinheimer-Haus EM AD - Department of Learning Health Sciences, University of Michigan, Ann Arbor, MI, United States. AD - Center for Global Health Equity, University of Michigan, Ann Arbor, MI, United States. FAU - Moyer, Cheryl A AU - Moyer CA AD - Department of Learning Health Sciences, University of Michigan, Ann Arbor, MI, United States. AD - Center for Global Health Equity, University of Michigan, Ann Arbor, MI, United States. FAU - Zhu, Ji AU - Zhu J AD - Department of Statistics, University of Michigan, Ann Arbor, MI, United States. FAU - Abubakar, Amina AU - Abubakar A AD - Institute for Human Development, Aga Khan University, Nairobi, Kenya. AD - Department of Psychiatry, University of Oxford, Oxford, United Kingdom. AD - Neuroscience Unit, Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya. LA - eng GR - U54 TW012089/TW/FIC NIH HHS/United States PT - Journal Article DEP - 20260317 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13036147 OTO - NOTNLM OT - machine learning OT - maternal mental health OT - postpartum anxiety OT - postpartum depression OT - predictive modeling COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/02 06:30 MHDA- 2026/04/02 06:31 PMCR- 2026/03/17 CRDT- 2026/04/02 04:46 PHST- 2026/01/19 00:00 [received] PHST- 2026/02/20 00:00 [revised] PHST- 2026/02/23 00:00 [accepted] PHST- 2026/04/02 06:30 [pubmed] PHST- 2026/04/02 06:31 [medline] PHST- 2026/04/02 04:46 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1790893 [doi] PST - epublish SO - Front Psychiatry. 2026 Mar 17;17:1790893. doi: 10.3389/fpsyt.2026.1790893. eCollection 2026. PMID- 41924059 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260402 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Protocol for AI-based prediction of problematic digital technology use among Indian youth: a Centre for Advanced Research on Addictive Behaviours initiative. PG - 1754046 LID - 10.3389/fpsyg.2026.1754046 [doi] LID - 1754046 AB - BACKGROUND: Artificial intelligence (AI) and machine learning have an important role in mental health research by helping to predict and prevent digital addiction and problematic digital technology use. These include behaviors linked with internet, smartphones, gaming, social media, gambling, over-the-top (OTT) platforms watching, pornography watching, shopping/ buying, and excessive screen time. OBJECTIVE: This multi-center study aims to develop and validate an AI-based predictive model to identify Indian youth at risk of problematic use of digital technology and associated psychological outcomes such as stress, anxiety, depression, and addiction. The study corresponds to one of the objectives of the Centre for Advanced Research on Addictive Behaviours (CAR-AB) initiative. METHODS: Students aged >/=12 years from schools and colleges across six Indian sites (New Delhi, Bhopal, Patna, Puducherry, Rishikesh, and Shillong) will be recruited. Data will be collected on demographic, psychological, behavioral, cognitive, socio-environmental, and digital phenotype correlates using validated instruments. Machine-learning models, including ensemble and deep-learning methods, will be trained, validated, and interpreted using explainable AI techniques. EXPECTED OUTCOMES: The study will develop a validated and interpretable predictive model for early detection of vulnerability to problematic use of digital technology. Findings are expected to inform targeted interventions, guide digital-wellness policies, and support the integration of predictive tools within educational, work, and community settings. CI - Copyright (c) 2026 Balhara, Ranjan, Sarkar, Kaur, Ganesh, Kattimani, Saxena, Das, Dhiman, Bhargava, Joshi, Majumdar, Singh and Patra. FAU - Balhara, Yatan Pal Singh AU - Balhara YPS AD - Behavioral Addictions Clinic (BAC) and Centre for Advanced Research on Addictive Behaviours (CAR-AB), National Drug Dependence Treatment Centre (NDDTC), All India Institute of Medical Sciences (AIIMS), New Delhi, India. FAU - Ranjan, Rajeev AU - Ranjan R AD - All India Institute of Medical Sciences, Patna, India. FAU - Sarkar, Siddharth AU - Sarkar S AD - AIIMS, New Delhi, India. FAU - Kaur, Simran AU - Kaur S AD - Department of Physiology, All India Institute of Medical Sciences (AIIMS), New Delhi, India. FAU - Ganesh, Ragul AU - Ganesh R AD - Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Puducherry, India. FAU - Kattimani, Shivanand AU - Kattimani S AD - Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Puducherry, India. FAU - Saxena, Vandena AU - Saxena V AD - CIE, Department of Education, University of Delhi, New Delhi, India. FAU - Das, Subhash AU - Das S AD - Department of Psychiatry, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Shillong, India. FAU - Dhiman, Vishal AU - Dhiman V AD - All India Institute of Medical Sciences, Rishikesh, India. FAU - Bhargava, Rachna AU - Bhargava R AD - AIIMS, New Delhi, India. FAU - Joshi, Tanmay AU - Joshi T AD - All India Institute of Medical Sciences, Bhopal, India. FAU - Majumdar, Anindo AU - Majumdar A AD - All India Institute of Medical Sciences, Bhopal, India. FAU - Singh, Swarndeep AU - Singh S AD - Vardhman Mahavir Medical College (VMMC), Safdarjung Hospital, New Delhi, India. FAU - Patra, Bichitra Nanda AU - Patra BN AD - Department of Psychiatry, AIIMS, New Delhi, India. LA - eng PT - Journal Article DEP - 20260317 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13036647 OTO - NOTNLM OT - AI-based predictive model OT - addiction OT - anxiety OT - depression OT - digital addiction OT - machine learning OT - problematic technology use OT - youth mental health COIS- YB is associated with Behavioral Addictions Clinic. He leads the Centre for Advanced Research on Addictive Behaviours (CAR-AB). He conducts research on addictive behaviors and other mental health issues. He reviews/edits journal articles and makes presentations on addictive behaviors. He offers advice as a technical expert on addictive behaviors to various not-for-profit entities. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/04/02 06:30 MHDA- 2026/04/02 06:31 PMCR- 2026/03/17 CRDT- 2026/04/02 04:38 PHST- 2025/11/25 00:00 [received] PHST- 2026/01/16 00:00 [revised] PHST- 2026/02/03 00:00 [accepted] PHST- 2026/04/02 06:31 [medline] PHST- 2026/04/02 06:30 [pubmed] PHST- 2026/04/02 04:38 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1754046 [doi] PST - epublish SO - Front Psychol. 2026 Mar 17;17:1754046. doi: 10.3389/fpsyg.2026.1754046. eCollection 2026. PMID- 41922936 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260714 IS - 2168-6602 (Electronic) IS - 0890-1171 (Linking) VI - 40 IP - 4 DP - 2026 May TI - Urban Green Space and Mental Health: Mediating Roles of Physical Activity and Social Cohesion. PG - 459-470 LID - 10.1177/08901171251388878 [doi] AB - PurposeThis study investigates the relationship between urban green spaces (UGS) and residents' mental health in Dhaka, Bangladesh, with a focus on the mediating roles of social cohesion and physical activity.DesignMultilevel regression and mediation analysis with cross-sectional data were constructed.Setting10 UGS in Dhaka were selected based on spatial variation.SampleA total of 276 adult residents (response rate: 85.2%) were surveyed using quota sampling to ensure demographic diversity.MeasuresThe Short Warwick-Edinburgh Mental Wellbeing Scale (SWEMWBS) was used for mental health assessment, validity scales for social cohesion and IPAQ-SF for physical activity. UGS accessibility and quality were evaluated using NDVI, GIS buffers, and on-site audits.AnalysisMultilevel linear regression and Sobel tests were employed to examine direct and mediated effects of UGS on mental health.ResultsUGS-level factors explained 18% of the variance in mental health. UGS accessibility (beta = 0.285***), safety (beta = 0.212***), and amenities (beta = 0.220***) were positively associated with mental health. Social cohesion (Z = 2.82***) and physical activity (Z = 2.15**) partially mediated these relationships.ConclusionUGS enhances mental health in dense urban environments through both direct and mediated pathways. Subgroup analysis reveals that high and medium-quality UGS have more substantial positive effects through physical activity and social cohesion on mental health. In contrast, the impact of low-quality UGS's is minor and insignificant. Respondents with higher education and income benefit more from UGS on their mental health. Future research using longitudinal data or experimental designs could enhance the robustness of causation. FAU - Ahmad, Maruf AU - Ahmad M AUID- ORCID: 0000-0002-0438-8028 AD - School of Public Policy and Administration, Xi'an Jiaotong University, Xi'an, Shaanxi, China. RINGGOLD: 12480 AD - Rural Development Academy (RDA), Bogura, Bangladesh. FAU - Du, Jinfeng AU - Du J AUID- ORCID: 0000-0001-5379-6813 AD - School of Public Policy and Administration, Xi'an Jiaotong University, Xi'an, Shaanxi, China. RINGGOLD: 12480 FAU - Rashid, Md Jubaer AU - Rashid MJ AUID- ORCID: 0009-0009-9816-783X AD - Sustainability Management, ICLEI South Asia, Dhaka, Bangladesh. LA - eng PT - Journal Article DEP - 20251014 PL - United States TA - Am J Health Promot JT - American journal of health promotion : AJHP JID - 8701680 SB - IM MH - Humans MH - *Mental Health/statistics & numerical data MH - Cross-Sectional Studies MH - *Exercise/psychology MH - Adult MH - Bangladesh MH - Female MH - Male MH - *Parks, Recreational MH - *Environment Design MH - Middle Aged MH - Socioeconomic Factors MH - Residence Characteristics MH - Urban Population MH - Neighborhood Characteristics MH - Young Adult MH - Adolescent OTO - NOTNLM OT - Dhaka OT - NDVI OT - mediation analysis OT - mental health OT - multilevel modeling OT - physical activity OT - social cohesion OT - urban green space OT - urban green spaces (UGS) COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/04/02 00:29 MHDA- 2026/04/02 06:30 CRDT- 2026/04/01 23:52 PHST- 2026/04/02 06:30 [medline] PHST- 2026/04/02 00:29 [pubmed] PHST- 2026/04/01 23:52 [entrez] AID - 10.1177/08901171251388878 [doi] PST - ppublish SO - Am J Health Promot. 2026 May;40(4):459-470. doi: 10.1177/08901171251388878. Epub 2025 Oct 14. PMID- 41920929 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 4 DP - 2026 TI - Unveiling the chain mediation model of sleep quality and fatigue in linking subjective exercise experience to depression in adolescent. PG - e0333460 LID - 10.1371/journal.pone.0333460 [doi] LID - e0333460 AB - While the positive correlation between physical exercise and depression has been widely replicated in cross-sectional research, the prognostic value of subjective exercise experience for depression continues to be disputed, and the mediating processes are not well understood. This study aims to elucidate the predictive role of subjective exercise experience in depression and examine the chain mediating effects of sleep quality and fatigue. We administered validated self-report questionnaires to assess these constructs in a sample of 538 Chinese high school students. The results demonstrated that adolescents' depressive symptoms are influenced by subjective exercise experience, and this effect mediated through two independent pathways: sleep quality and fatigue. Moreover, subjective exercise experience can predict adolescent depression via either the sleep quality pathway or the fatigue pathway. The identification of mediating dual pathways provides empirical support for developing targeted exercise interventions that specifically address sleep disturbances and fatigue management in depressed adolescents. CI - Copyright: (c) 2026 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Li, Xiaoyu AU - Li X AD - School of Physical Education, University of Jinan, Jinan, Shan Dong, China. FAU - Yang, Qian AU - Yang Q AD - School of Physical Education, University of Jinan, Jinan, Shan Dong, China. FAU - Qi, Ziyang AU - Qi Z AD - School of Education and Psychology, University of Jinan, Jinan, Shan Dong, China. FAU - Ma, Changhao AU - Ma C AD - School of Physical Education, University of Jinan, Jinan, Shan Dong, China. FAU - Qi, Shenghua AU - Qi S AD - School of Physical Education, University of Jinan, Jinan, Shan Dong, China. FAU - Ji, Wenliang AU - Ji W AUID- ORCID: 0009-0005-2138-0860 AD - School of Physical Education, University of Jinan, Jinan, Shan Dong, China. LA - eng PT - Journal Article DEP - 20260401 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Adolescent MH - *Fatigue/physiopathology/psychology MH - *Depression/physiopathology MH - *Exercise/psychology MH - *Sleep Quality MH - Female MH - Male MH - Surveys and Questionnaires MH - Self Report PMC - PMC13043057 EDAT- 2026/04/01 18:30 MHDA- 2026/04/01 18:31 PMCR- 2026/04/01 CRDT- 2026/04/01 13:53 PHST- 2025/09/19 00:00 [received] PHST- 2026/03/03 00:00 [accepted] PHST- 2026/04/01 18:31 [medline] PHST- 2026/04/01 18:30 [pubmed] PHST- 2026/04/01 13:53 [entrez] PHST- 2026/04/01 00:00 [pmc-release] AID - PONE-D-25-44933 [pii] AID - 10.1371/journal.pone.0333460 [doi] PST - epublish SO - PLoS One. 2026 Apr 1;21(4):e0333460. doi: 10.1371/journal.pone.0333460. eCollection 2026. PMID- 41917889 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Apr 1 TI - Educational practices for promoting healthy hydration in primary education in the face of climate change: a systematic review of the literature. LID - 10.1186/s12887-026-06773-y [doi] LID - 431 AB - Climate change is increasing children's exposure to heat and, consequently, their risk of dehydration during their primary school years. Yet hydration education is not consistently embedded in education policy or primary curricula. This systematic review, reported in accordance with PRISMA 2020, examined school-based educational practices designed to promote healthy hydration in Primary Education (6 to 12 years). A search was conducted in the Web of Science Core Collection on January 29th, 2025 for studies published between 2015 and 2024. Two reviewers independently screened records and assessed risk of bias using design-appropriate tools (RoB 2, ROBINS-I, and JBI checklists). Given the substantial heterogeneity in intervention components and outcome indicators, a narrative synthesis was performed. Twelve studies were included, spanning randomized and non-randomized interventions and observational and qualitative or documentary designs across diverse school contexts. Overall, multi-component approaches, particularly those combining improved access to drinking water with classroom-based educational activities and routine supports, were associated with increased water intake, and when measured, improved physiological hydration indicators. Evidence for broader outcomes, including cognitive or academic measures and sustainability-related awareness, was mixed and dependent on the outcome assessed. Risk of bias ranged from low to high; common limitations included reliance on self-reported intake, short intervention duration, limited control for confounding in non-randomized designs, and scarce medium- to long-term follow-up. Future research should prioritize standardized and validated hydration measures, clearer specification of educational strategies, including teacher roles and competencies, and longer follow-up to strengthen the evidence base under climate-related heat risks. FAU - Fornons-Casol, Laura AU - Fornons-Casol L AUID- ORCID: 0009-0008-0373-4225 AD - Department of Education Sciences, Universitat de Lleida, C/ Av. Estudi General 4, Lleida, 25001, Spain. laura.fornons@udl.cat. FAU - Ramos-Pla, Anabel AU - Ramos-Pla A AUID- ORCID: 0000-0001-5437-150X AD - Department of Education Sciences, Universitat de Lleida, C/ Av. Estudi General 4, Lleida, 25001, Spain. FAU - Olondriz-Valverde, Aleix AU - Olondriz-Valverde A AUID- ORCID: 0000-0001-6456-388X AD - Department of Education Sciences, Universitat de Lleida, C/ Av. Estudi General 4, Lleida, 25001, Spain. FAU - Selva-Pareja, Laia AU - Selva-Pareja L AUID- ORCID: 0000-0002-7443-7470 AD - Department of Nursing and Physiotherapy, Universitat de Lleida, C/ de Montserrat Roig 2, Lleida, 25198, Spain. LA - eng GR - (Project Code: 2023 CLIMA 00047)/Department of Research and Universities, the Department of Climate Action, Food and Rural Agenda, and the Climate Fund of the Generalitat de Catalunya/ PT - Journal Article PT - Systematic Review DEP - 20260401 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Climate Change MH - *Dehydration/prevention & control MH - Child MH - *Health Promotion/methods MH - Schools MH - Drinking PMC - PMC13169862 OTO - NOTNLM OT - Health education OT - Hydration OT - Primary Education OT - School-based intervention OT - Systematic review COIS- Declarations. Ethics approval and consent to participate: The project HIDROPONENT received a favourable approval from the Comite de Etica de Investigacion y Transferencia, University of Lleida, on 9 December 2025, reference number CERT198. The present manuscript is a systematic review of published literature and did not involve human participants or the collection of new personal data; therefore, consent to participate was not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/01 07:04 MHDA- 2026/06/27 12:37 PMCR- 2026/04/01 CRDT- 2026/04/01 01:18 PHST- 2026/01/22 00:00 [received] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/06/27 12:37 [medline] PHST- 2026/04/01 07:04 [pubmed] PHST- 2026/04/01 01:18 [entrez] PHST- 2026/04/01 00:00 [pmc-release] AID - 10.1186/s12887-026-06773-y [pii] AID - 6773 [pii] AID - 10.1186/s12887-026-06773-y [doi] PST - epublish SO - BMC Pediatr. 2026 Apr 1;26(1):431. doi: 10.1186/s12887-026-06773-y. PMID- 41917678 OWN - NLM STAT- MEDLINE DCOM- 20260614 LR - 20260902 IS - 1526-3231 (Electronic) IS - 0749-8063 (Linking) VI - 42 IP - 6 DP - 2026 Jun TI - Smaller Lateral-to-Medial Tibial Plateau Ratios Are Strongly Correlative With Anterior Cruciate Ligament Tears and Reconstruction Failures. PG - 1030-1038 LID - 10.1002/arj.70149 [doi] AB - PURPOSE: To compare the anterior-posterior distance ratio of the lateral-to-medial tibial plateau (LTP/MTP) among 3 patient groups: those with intact anterior cruciate ligaments (ACLi), primary ACL tears (ACLp), and failed ACL reconstructions (ACLf). METHODS: We retrospectively identified skeletally mature patients (16-40 years) who underwent knee magnetic resonance imaging between May 2013 and March 2022. Patients were included if they had adequate radiographs and magnetic resonance imaging available and were required to have a minimum of 2 years of follow-up for confirmation of ACL status. The anterior to posterior distance of the LTP and anterior to posterior distance of the MTP were measured on axial T1 magnetic resonance imaging to compute LTP/MTP. Tibial eminence width was measured between tibial spine peaks on coronal T1 magnetic resonance imaging. Posterior tibial slope (PTS) was calculated on lateral knee radiographs. Multivariate logistic regression identified predictors of ACLp and ACLf. RESULTS: Demographic characteristics: age, sex, and body mass index were no different between groups. The intraclass correlation coefficients for the morphometric measurements ranged from 0.750 to 0.902 indicating good to excellent agreement among the 3 raters and intrarater reliability testing. Mean PTS was significantly higher in ACLf (12.1 +/- 2.9 degrees ) compared with ACLi (10.3 +/- 2.0 degrees ) and ACLp (10.6 +/- 2.6 degrees ) (P < .001). The mean LTP/MTP ratio was significantly lower in ACLp (0.79 +/- 0.06) and ACLf (0.77 +/- 0.06) versus ACLi (0.84 +/- 0.06) (P < .001). In logistic regression comparing ACLp to ACLi, a lower LTP/MTP ratio was the only significant morphologic predictor (odds ratio [OR], 0.87; 95% confidence interval [CI]: 0.80-0.95). In contrast, when compared with ACLi, ACLf were significantly predicted by a lower LTP/MTP ratio (OR, 0.82; 95% CI: 0.74-0.91), higher PTS (OR, 1.38; 95% CI: 1.14-1.73), and narrower tibial eminence width (OR, 0.70; 95% CI: 0.51-0.94). A direct comparison found that higher PTS, narrower tibial eminence width, and higher body mass index were significantly associated with ACLf versus a ACLp. For every 1-degree increase in PTS, the odds of a retear versus ACL increased by 38%. CONCLUSIONS: This study identifies the LTP/MTP ratio as a key anatomical risk factor for ACL injury. Specifically, a smaller LTP/MTP ratio was associated with a significantly higher odds of both primary ACL tears and subsequent retears relative to individuals without ACL injury. LEVEL OF EVIDENCE: Level III, retrospective comparative study. CI - (c) 2026 The Author(s). Arthroscopy published by Wiley Periodicals LLC on behalf of the Arthroscopy Association of North America. FAU - Ihn, Hansel E AU - Ihn HE AD - Department of Orthopaedics, University of Utah, Salt Lake City, Utah, U.S.A. FAU - Hunter, Collin D R AU - Hunter CDR AUID- ORCID: 0000-0001-7677-0667 AD - Department of Orthopaedics, University of Utah, Salt Lake City, Utah, U.S.A. FAU - Mortensen, Alexander J AU - Mortensen AJ AD - Department of Orthopaedics, University of Utah, Salt Lake City, Utah, U.S.A. FAU - Johnson, Benjamin T AU - Johnson BT AUID- ORCID: 0000-0002-5360-732X AD - Department of Orthopaedics, University of Utah, Salt Lake City, Utah, U.S.A. FAU - Eddington, Devin AU - Eddington D AD - Division of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, U.S.A. FAU - Aoki, Stephen K AU - Aoki SK AD - Department of Orthopaedics, University of Utah, Salt Lake City, Utah, U.S.A. FAU - Ernat, Justin J AU - Ernat JJ AUID- ORCID: 0000-0003-2306-7745 AD - Department of Orthopaedics, University of Utah, Salt Lake City, Utah, U.S.A. LA - eng PT - Journal Article DEP - 20260331 PL - United States TA - Arthroscopy JT - Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association JID - 8506498 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Young Adult MH - *Anterior Cruciate Ligament Injuries/surgery/diagnostic imaging/pathology MH - *Anterior Cruciate Ligament Reconstruction MH - Magnetic Resonance Imaging MH - Retrospective Studies MH - *Tibia/diagnostic imaging/pathology/anatomy & histology MH - Treatment Failure EDAT- 2026/04/01 07:04 MHDA- 2026/06/15 11:33 CRDT- 2026/04/01 00:05 PHST- 2025/05/22 00:00 [received] PHST- 2025/11/06 00:00 [accepted] PHST- 2026/06/15 11:33 [medline] PHST- 2026/04/01 07:04 [pubmed] PHST- 2026/04/01 00:05 [entrez] AID - 10.1002/arj.70149 [doi] PST - ppublish SO - Arthroscopy. 2026 Jun;42(6):1030-1038. doi: 10.1002/arj.70149. Epub 2026 Mar 31. PMID- 41917629 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260714 IS - 0065-2598 (Print) IS - 0065-2598 (Linking) VI - 1505 DP - 2026 TI - Assessment of Adolescent Growth and Development. PG - 145-158 LID - 10.1007/978-981-95-7000-3_7 [doi] AB - Evaluating growth and development is crucial to understanding the health status of adolescents. This assessment, through physical examination, requires healthcare experts and can be challenging due to subjectivity and privacy concerns. Similarly, psychosocial growth is subjective and also requires complex evaluations by professionals. This complexity makes physical growth assessment based on anthropometric measures a more useful and convenient indicator for monitoring growth. Therefore, anthropometric measurements should be assessed with more precise methods and calibrated equipment. Considerations of precision, reliability, and validity are essential for growth assessments when planning health strategies, nutritional status, and overall well-being. The study design should be carefully selected based on the objectives. An adequate sample size is also critical in capturing the true variability of the study population. Adolescents undergo a growth spurt due to prepuberty and puberty; thus, the development of growth centile charts necessitates appropriate assessment methodology and validations to effectively evaluate growth status and capture its variations. The differences, velocity, and acceleration charts are essential in creating reference growth centiles for a population, especially for adolescents. The appropriate statistical methodology, based on exploratory data analysis and modeling for estimating centiles, has fundamental implications. GAMLSS is a more flexible model that can capture the growth spurt due to puberty in adolescents, utilizing various distribution families, smoothing functions, and the ability to model each parameter with multiple covariates. Cross-validation enhances confidence in the generalizability of the statistical model and growth centiles for the target population. These growth centile charts are vital for early detection of growth disorders, nutritional assessments, monitoring, and informed decision-making in clinical and public health contexts. CI - (c) 2026. The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. FAU - Khurram, Haris AU - Khurram H AD - National University of Computer and Emerging Sciences, Chiniot-Faisalabad Campus, Faisalabad, Pakistan. haris.khurram@nu.edu.pk. LA - eng PT - Journal Article PT - Review PL - United States TA - Adv Exp Med Biol JT - Advances in experimental medicine and biology JID - 0121103 SB - IM MH - Humans MH - Adolescent MH - *Adolescent Development/physiology MH - Growth Charts MH - Puberty/physiology MH - Anthropometry/methods OTO - NOTNLM OT - Adolescents OT - GAMLSS OT - Growth assessment OT - Growth centiles OT - Growth charts OT - Nutrition status EDAT- 2026/04/01 07:04 MHDA- 2026/04/01 07:05 CRDT- 2026/04/01 00:04 PHST- 2026/04/01 07:05 [medline] PHST- 2026/04/01 07:04 [pubmed] PHST- 2026/04/01 00:04 [entrez] AID - 10.1007/978-981-95-7000-3_7 [doi] PST - ppublish SO - Adv Exp Med Biol. 2026;1505:145-158. doi: 10.1007/978-981-95-7000-3_7. PMID- 41917087 OWN - NLM STAT- MEDLINE DCOM- 20260518 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Mar 31 TI - Prediction of individual optimal drop height in drop jump from anthropometric and strength variables. LID - 10.1038/s41598-026-45266-x [doi] LID - 15270 AB - This study aimed to investigate the associations between individual optimal drop height (ODH), as determined by the reactive strength index (RSI) method, and selected anthropometric and strength parameters, and to develop a prediction model for ODH based on these variables. A total of 49 participants were recruited, and measurements included body height, body mass, maximal muscle strength (MSmax), lower limb stiffness, reactive strength ratio (RSR), countermovement jump (CMJ) height, and ODH. Pearson correlation analysis was conducted to examine the relationships between ODH and the assessed variables. A multiple linear regression model was constructed in a stepwise manner to predict individual ODH. Significant correlations were observed between ODH and relative MSmax (r = 0.827, P < 0.001), RSR (r = 0.703, P < 0.001), body mass (r = -0.481, P < 0.01), body height (r = -0.430, P < 0.01), and CMJ height (r = 0.487, P < 0.01). Relative MSmax, CMJ height and RSR collectively explained 78.4% of the variance in ODH (R(2) = 0.784). The final prediction equation was: ODH = -45.602+31.027*relative MS(max) +0.548*CMJ height +5.549*RSR (R(2) = 0.784, F (3, 36) = 48.190, p < 0.001). Coaches should consider body height, body mass, RSR, relative MSmax, and CMJ height when prescribing drop jump height. Moreover, an individual's ODH should be adjusted when changes in CMJ height or relative MSmax occur. Finally, this study provides a practical prediction equation for estimating individual ODH using relative MSmax and CMJ height as input variables. CI - (c) 2026. The Author(s). FAU - Xie, Yongmin AU - Xie Y AD - School of Strength and Conditioning Training, Beijing Sport University, Haidian, 100084, China. xieyongminbsu@163.com. FAU - Peng, Fan AU - Peng F AD - School of Strength and Conditioning Training, Beijing Sport University, Haidian, 100084, China. FAU - Pan, Xinyu AU - Pan X AD - School of Strength and Conditioning Training, Beijing Sport University, Haidian, 100084, China. FAU - Sun, Qinchang AU - Sun Q AD - School of Strength and Conditioning Training, Beijing Sport University, Haidian, 100084, China. LA - eng PT - Journal Article DEP - 20260331 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Cross-Sectional Studies MH - *Anthropometry/methods MH - *Body Mass Index MH - *Body Height/physiology MH - *Muscle Strength/physiology MH - *Exercise Test/methods/statistics & numerical data MH - Humans MH - Male MH - Adolescent MH - Young Adult MH - Athletes/statistics & numerical data MH - Athletic Performance/physiology MH - Plyometric Exercise/methods MH - Predictive Value of Tests MH - Reproducibility of Results MH - Regression Analysis PMC - PMC13181053 OTO - NOTNLM OT - Optimal drop height OT - Plyometric training OT - Reactive strength OT - Training intensity COIS- Decleartions. Competing interests: The authors declare no competing interests. EDAT- 2026/04/01 00:29 MHDA- 2026/05/18 00:30 PMCR- 2026/03/31 CRDT- 2026/03/31 23:39 PHST- 2025/08/10 00:00 [received] PHST- 2026/03/17 00:00 [accepted] PHST- 2026/05/18 00:30 [medline] PHST- 2026/04/01 00:29 [pubmed] PHST- 2026/03/31 23:39 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - 10.1038/s41598-026-45266-x [pii] AID - 45266 [pii] AID - 10.1038/s41598-026-45266-x [doi] PST - epublish SO - Sci Rep. 2026 Mar 31;16(1):15270. doi: 10.1038/s41598-026-45266-x. PMID- 41916414 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1502-7724 (Electronic) IS - 0281-3432 (Print) IS - 0281-3432 (Linking) VI - 44 IP - 1 DP - 2026 Dec TI - Screening for iron deficiency in young women: the predictive validity of a five-item screening instrument (IRON-5). PG - 2649329 LID - 10.1080/02813432.2026.2649329 [doi] LID - 2649329 AB - BACKGROUND: Iron deficiency is the most common micronutrient deficiency worldwide, negatively affecting quality of life and health. Young women are at particularly high risk due to increased iron demands during growth, menstrual blood losses, and dietary habits. There are no official guidelines recommending screening for iron deficiency in healthy young women. This study aimed to develop a screening instrument (IRON-5) to predict iron deficiency in this group, with relevance for use in primary care and school health services. METHODS: In 2023, a cross-sectional study was conducted to assess the prevalence of iron deficiency and associated factors in high school girls. A questionnaire assessing dietary habits, menstrual bleeding patterns, iron supplement use, and hormonal contraceptive use was administered. Iron deficiency was defined as serum ferritin <15 microg/L. A post-hoc analysis identified the strongest predictors of iron deficiency and incorporated them into a risk-scoring model. RESULTS: The final instrument included five predictors: a non-omnivorous diet, heavy menstruation causing discomfort, avoidance of activities due to menstruation, no iron supplementation, and non-use of hormonal contraceptives. A scoring system (0-5) was developed. Using a threshold score of >/= 3, the model achieved a sensitivity of 74% and specificity of 57% for detecting iron deficiency. CONCLUSION: The IRON-5 is a concise and user-friendly screening instrument designed to identify young women at risk of iron deficiency. It demonstrated good sensitivity and may serve as a cost-effective method to prioritize individuals for blood testing. IRON-5 could support identification and prevention strategies in school-based and primary care settings. FAU - Vinge, Fredrik AU - Vinge F AUID- ORCID: 0009-0007-9498-1573 AD - Centre for Primary Health Care Research, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden. AD - University Clinic Primary Care, Skane University Hospital, Region Skane, Sweden. FAU - Stubbendorff, Anna AU - Stubbendorff A AUID- ORCID: 0000-0001-9851-6213 AD - Nutritional Epidemiology, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden. FAU - Bolmsjo, Beata Borgstrom AU - Bolmsjo BB AUID- ORCID: 0000-0001-7655-0613 AD - Centre for Primary Health Care Research, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden. AD - University Clinic Primary Care, Skane University Hospital, Region Skane, Sweden. FAU - Jakobsson, Ulf AU - Jakobsson U AUID- ORCID: 0000-0003-3676-307X AD - Centre for Primary Health Care Research, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden. AD - University Clinic Primary Care, Skane University Hospital, Region Skane, Sweden. FAU - Milos Nymberg, Veronica AU - Milos Nymberg V AUID- ORCID: 0000-0002-3836-3048 AD - Centre for Primary Health Care Research, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden. AD - University Clinic Primary Care, Skane University Hospital, Region Skane, Sweden. FAU - Wolff, Moa AU - Wolff M AUID- ORCID: 0000-0002-0656-7628 AD - Centre for Primary Health Care Research, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden. AD - University Clinic Primary Care, Skane University Hospital, Region Skane, Sweden. LA - eng PT - Journal Article DEP - 20260331 PL - United States TA - Scand J Prim Health Care JT - Scandinavian journal of primary health care JID - 8510679 RN - 9007-73-2 (Ferritins) RN - E1UOL152H7 (Iron) SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Adolescent MH - *Anemia, Iron-Deficiency/diagnosis/epidemiology MH - Surveys and Questionnaires MH - *Mass Screening/methods MH - Ferritins/blood MH - Prevalence MH - *Iron Deficiencies MH - Menstruation MH - Dietary Supplements MH - Sensitivity and Specificity MH - Feeding Behavior MH - Primary Health Care MH - Iron MH - Diet PMC - PMC13047845 OTO - NOTNLM OT - Iron deficiency OT - adolescent OT - dietary habits OT - female OT - mass screening OT - primary health care OT - risk assessment COIS- No potential conflict of interest was reported by the author(s). EDAT- 2026/04/01 00:28 MHDA- 2026/04/01 00:29 PMCR- 2026/03/31 CRDT- 2026/03/31 19:13 PHST- 2026/04/01 00:29 [medline] PHST- 2026/04/01 00:28 [pubmed] PHST- 2026/03/31 19:13 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - 2649329 [pii] AID - 10.1080/02813432.2026.2649329 [doi] PST - ppublish SO - Scand J Prim Health Care. 2026 Dec;44(1):2649329. doi: 10.1080/02813432.2026.2649329. Epub 2026 Mar 31. PMID- 41915661 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 3 DP - 2026 TI - Validity and reliability of Indonesian version of the digital screen exposure questionnaire (DSEQ) for young children. PG - e0346133 LID - 10.1371/journal.pone.0346133 [doi] LID - e0346133 AB - Studies have shown that excessive screen time in early childhood can negatively affect development. Therefore, assessing screen exposure in young children is important for preventing these negative effects. However, only a limited number of validated and reliable tools have been adapted into the Indonesian language. This study aimed to translate, culturally adapt, and evaluate the validity and reliability of the Digital Screen Exposure Questionnaire (DSEQ) for Indonesian children aged 2-5 years. This cross-sectional study included 171 caregivers. The translation and adaptation processes followed internationally accepted guidelines for patient-reported outcomes measures, with content and face validity evaluated through expert reviews. Reliability was assessed based on the COSMIN guidelines and previous studies, with internal consistency measured using Cronbach's alpha and test-retest reliability assessed in a subsample of 31 caregivers using the intraclass correlation coefficient (ICC). This study is the first cultural adaptation of the DSEQ in Indonesia and demonstrates good face and content validity, as confirmed by expert evaluations. Internal consistency (Cronbach's alpha) was strong for screen-time exposure and home media environment (0.704), media-related behaviors (0.863), and physical activity (0.768), whereas test-retest reliability across the three domains was moderate to high (ICC values: 0.514-0.946), with lower ICC values observed for the item related to parental supervision while watching television, which may vary owing to differences in household routines and parental availability. These findings support the Indonesian DSEQ as a valid and reliable tool for evaluating exposure to digital screens among children. CI - Copyright: (c) 2026 Khatimah et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Khatimah, Nur Faidar Khusnul AU - Khatimah NFK AUID- ORCID: 0009-0006-4838-0200 AD - Department of Physical Therapy, Graduate School of Human Health Science, Tokyo Metropolitan University, Arakawa, Tokyo, Japan. FAU - Jusriani, Jusriani AU - Jusriani J AD - Keanna Center, Optimum Child Growth and Development Center, Makassar, South Sulawesi, Indonesia. FAU - Wulandari, Desi AU - Wulandari D AD - OrthoTrimedical Care Center, Orthotic-Prosthetic and Child Development Therapy Center, Makassar, South Sulawesi, Indonesia. FAU - Gima, Hirotaka AU - Gima H AUID- ORCID: 0009-0007-0630-8400 AD - Department of Physical Therapy, Graduate School of Human Health Science, Tokyo Metropolitan University, Arakawa, Tokyo, Japan. LA - eng PT - Journal Article PT - Validation Study DEP - 20260331 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Indonesia MH - Child, Preschool MH - Surveys and Questionnaires MH - Female MH - Reproducibility of Results MH - Male MH - Cross-Sectional Studies MH - *Screen Time MH - Media Exposure MH - Digital Media PMC - PMC13037967 COIS- The authors have declared that no competing interests exist. EDAT- 2026/03/31 18:49 MHDA- 2026/03/31 18:50 PMCR- 2026/03/31 CRDT- 2026/03/31 13:33 PHST- 2025/11/19 00:00 [received] PHST- 2026/03/15 00:00 [accepted] PHST- 2026/03/31 18:50 [medline] PHST- 2026/03/31 18:49 [pubmed] PHST- 2026/03/31 13:33 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - PONE-D-25-62221 [pii] AID - 10.1371/journal.pone.0346133 [doi] PST - epublish SO - PLoS One. 2026 Mar 31;21(3):e0346133. doi: 10.1371/journal.pone.0346133. eCollection 2026. PMID- 41915137 OWN - NLM STAT- MEDLINE DCOM- 20260629 LR - 20260702 IS - 0974-7559 (Electronic) IS - 0019-6061 (Linking) VI - 63 IP - 7 DP - 2026 Jul TI - Development and Validation of Obesity Interpreter: A Mobile Application-Based Tool for Children and Adolescents. PG - 474-479 LID - 10.1007/s13312-026-00312-9 [doi] AB - OBJECTIVE: To develop and validate Obesity Interpreter, a mobile application tool to assist in assessing children with obesity and avoid unwarranted workup in physiological obesity. METHODS: The Obesity Interpreter offers guidance on probable diagnoses and workup based on clinical inputs. The validation involved comparing the guidance from the Obesity Interpreter, a pediatric endocrinologist, a pediatrician, and a trainee on the final diagnosis (gold standard) in 400 children and adolescents with obesity concerns (270 constitutional, 23 genetic/syndromic, 11 drug-induced, 13 endocrine, 83 normal or overweight). RESULTS: The concordance scores were higher for the endocrinologist (92.1%) and the Obesity Interpreter (99.5%) compared to the pediatrician (75.4%) and the trainee (56.6%). The workup guidance of the Obesity Interpreter aligned with the gold standard in 398 (99.5%) subjects (Cohen's kappa 0.989, 95% CI 0.971, 1.0). Diagnostic workup discrepancies were noted in 83 (20.8%) subjects by the pediatrician and in 162 (40.5%) subjects by the trainee. Utilizing the mobile application would have prevented 288/ 292 (98.6%) errors observed in the study with high agreement for classification recommendation (Cohen's kappa 0.990, 95% CI 0.975, 1.0). CONCLUSION: Obesity Interpreter provided guidance aligned with the gold standard for evaluation of children with obesity. CI - (c) 2026. The Author(s), under exclusive licence to Indian Academy of Pediatrics. FAU - Raithatha, Dhvani AU - Raithatha D AD - Department of Pediatric Endocrinology, Regency Healthcare, A2 Sarvodaya Nagar, Kanpur, Uttar Pradesh, India. FAU - Bajpai, Anurag AU - Bajpai A AUID- ORCID: 0000-0002-3701-2780 AD - Department of Pediatric Endocrinology, Regency Healthcare, A2 Sarvodaya Nagar, Kanpur, Uttar Pradesh, India. dranurag.bajpai@gmail.com. FAU - Narayanan, R AU - Narayanan R AD - Department of Pediatric Endocrinology, Regency Healthcare, A2 Sarvodaya Nagar, Kanpur, Uttar Pradesh, India. FAU - Mahapatra, Alapan AU - Mahapatra A AD - Department of Pediatric Endocrinology, Regency Healthcare, A2 Sarvodaya Nagar, Kanpur, Uttar Pradesh, India. FAU - Yadav, Vibha AU - Yadav V AD - Department of Pediatric Endocrinology, Regency Healthcare, A2 Sarvodaya Nagar, Kanpur, Uttar Pradesh, India. FAU - Joshi, Prachi AU - Joshi P AD - Department of Pediatrics, King George Medical University, Lucknow, Uttar Pradesh, India. FAU - Zehra, Alia AU - Zehra A AD - Department of Pediatrics, King George Medical University, Lucknow, Uttar Pradesh, India. FAU - Bhriguvanshi, Arpita AU - Bhriguvanshi A AD - Department of Pediatrics, King George Medical University, Lucknow, Uttar Pradesh, India. LA - eng PT - Journal Article PT - Validation Study DEP - 20260331 PL - India TA - Indian Pediatr JT - Indian pediatrics JID - 2985062R SB - IM MH - Humans MH - Child MH - Adolescent MH - *Mobile Applications MH - *Pediatric Obesity/diagnosis MH - Female MH - Male MH - Medical Interpreting OTO - NOTNLM OT - Body mass index OT - Childhood obesity OT - Metabolic dysfunction-associated steatotic liver disease OT - Metabolic syndrome OT - Pathological obesity OT - Prevention COIS- Conflict of interest: AB is one of the Directors of MedEClasses, a start-up involved in medical education, and has 60% of the non-listed company holdings. The Obesity Interpreter is part of the MedEClasses Endocrinology Mobile Application. Ethics Approval: This study was approved by the Institutional Ethics Committee, Regency Healthcare, Kanpur; Ref. No. IEC Number RHL-lEC-16060 dated January 07, 2022. EDAT- 2026/03/31 12:33 MHDA- 2026/06/30 00:31 CRDT- 2026/03/31 11:07 PHST- 2025/07/18 00:00 [received] PHST- 2026/03/05 00:00 [accepted] PHST- 2026/06/30 00:31 [medline] PHST- 2026/03/31 12:33 [pubmed] PHST- 2026/03/31 11:07 [entrez] AID - 10.1007/s13312-026-00312-9 [pii] AID - 10.1007/s13312-026-00312-9 [doi] PST - ppublish SO - Indian Pediatr. 2026 Jul;63(7):474-479. doi: 10.1007/s13312-026-00312-9. Epub 2026 Mar 31. PMID- 41914331 OWN - NLM STAT- MEDLINE DCOM- 20260824 LR - 20260824 IS - 1941-0921 (Electronic) IS - 1941-7381 (Print) IS - 1941-0921 (Linking) VI - 18 IP - 5 DP - 2026 Sep-Oct TI - Sport-Specific Outcome Measures Improve Clinical Assessment of Shoulder Injury in Swimmers: A Cohort Study of Specific PROMs. PG - 960-968 LID - 10.1177/19417381261431350 [doi] LID - 19417381261431350 AB - BACKGROUND: Swimming is among the most widely practiced sports globally. Up to 70% of swimmers report shoulder pain that impairs performance. Patient-reported outcome measures (PROMs) are effective, objective tools for assessing such injuries. The aim of this study was to develop and validate swimming-specific adaptations of established shoulder PROMs (ASES-swim and SSV-swim) and compare their psychometric properties and discriminatory ability with generic existing instruments. HYPOTHESIS: Swimming-specific PROMs may more accurately assess shoulder condition in swimmers and monitor recovery, thereby enabling improved evaluation of health status and, ultimately, athletic performance. STUDY DESIGN: Cohort study. METHODS: A total of 167 athletes registered with the Portuguese Swimming Federation (FPN) during the 2023-2024 season were enrolled. Participants were stratified into asymptomatic group (AG = 92) and injured group (IG = 75). Monthly assessments included training characteristics, injury status, and responses to ASES, SSV, SSV-sport, and newly developed ASES-swim and SSV-swim questionnaires over 6 months. RESULTS: SSV-swim correlated strongly with SSV and SSV-sport (r = 0.769, P < 0.001 and r = 0.857, P < 0.001, respectively). ASES-swim scores were highly correlated with ASES scores (r = 0.994, P < 0.001). Both SSV-swim and ASES-swim demonstrated higher internal consistency than the nonadapted PROMs (Cronbach alpha = 0.849 and 0.870, respectively). SSV, SSV-sport, and SSV-swim showed moderate discriminatory ability (area under the curve [AUC] = 0.760, 0.809, and 0.851, respectively), whereas ASES and ASES-swim showed excellent discriminatory ability for detecting injury (AUC = 0.967 and 0.970, respectively). CONCLUSION: ASES-swim and SSV-swim are a valid, reliable, and easy to administer tool for the assessment of shoulder injury and recovery in swimmers. Swimming-specific PROMs provide clinically meaningful improvements in shoulder injury assessment accuracy. CLINICAL RELEVANCE: Swimming-specific PROMs provide clinicians with a sensitive and reliable method for assessing shoulder injury in swimmers, enabling more accurate diagnosis and individualized rehabilitation. Further research should investigate sports-specific PROM adaptations to optimize athlete care across disciplines. FAU - Sousa, Diogo Nunes AU - Sousa DN AUID- ORCID: 0009-0003-3719-5569 AD - Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. AD - ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimaraes, Portugal. FAU - Velho, Tiago AU - Velho T AUID- ORCID: 0009-0004-8529-9263 AD - Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. AD - ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimaraes, Portugal. FAU - Escaleira, Rui AU - Escaleira R AUID- ORCID: 0009-0005-0047-8631 AD - Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. AD - ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimaraes, Portugal. AD - Surgery Department, ULSAM Alto Ave, Viana do Castelo, Portugal. AD - Portuguese Swimming Federation. FAU - Moedas, Daniel AU - Moedas D AUID- ORCID: 0009-0007-2228-746X AD - Portuguese Swimming Federation. FAU - Campos, Barbara AU - Campos B AUID- ORCID: 0000-0001-9415-020X AD - Shoulder and Elbow Unit, Orthopaedics Department, Hospital CUF Tejo, Lisboa, Portugal. FAU - Medeiros-Filho, Joao Felipe AU - Medeiros-Filho JF AUID- ORCID: 0000-0002-4745-4566 AD - Universidade Federal do Rio Grande do Norte Natal, RN, Brazil. FAU - Pereira, Helder AU - Pereira H AUID- ORCID: 0000-0003-2220-6766 AD - Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. AD - ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimaraes, Portugal. AD - Orthopaedics Department, ULSAM Povoa de Varzim/Vila do Conde, Povoa de Varzim, Portugal. AD - Ripoll y De Prado Sports Clinic: Murcia-Madrid FIFA Medical Centre of Excellence, Madrid, Spain. FAU - Malavolta, Eduardo AU - Malavolta E AUID- ORCID: 0000-0003-1956-6445 AD - Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil. AD - HCOR, Sao Paulo, SP, Brazil. FAU - Sevivas, Nuno AU - Sevivas N AUID- ORCID: 0000-0002-6573-0368 AD - Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. AD - ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimaraes, Portugal. AD - Shoulder and Elbow Unit, Orthopaedics Department, ULSAM Medio Ave, Famalicao, Portugal. AD - Shoulder and Elbow Unit, Orthopaedics Department, Trofa Saude Hospital Braga Sul, Braga, Portugal. LA - eng PT - Journal Article PT - Validation Study DEP - 20260331 PL - United States TA - Sports Health JT - Sports health JID - 101518422 SB - IM MH - Humans MH - *Swimming/injuries MH - *Patient Reported Outcome Measures MH - *Shoulder Injuries/diagnosis MH - Male MH - Psychometrics MH - Female MH - Adolescent MH - Cohort Studies MH - *Athletic Injuries/diagnosis MH - Young Adult MH - Surveys and Questionnaires PMC - PMC13038485 OTO - NOTNLM OT - patient-reported outcome measures (PROMs) OT - shoulder OT - sports medicine OT - swimming COIS- The authors report no potential conflicts of interest in the development or publication of this article. EDAT- 2026/03/31 12:33 MHDA- 2026/08/24 18:42 PMCR- 2026/03/31 CRDT- 2026/03/31 06:03 PHST- 2026/08/24 18:42 [medline] PHST- 2026/03/31 12:33 [pubmed] PHST- 2026/03/31 06:03 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - 10.1177_19417381261431350 [pii] AID - 10.1177/19417381261431350 [doi] PST - ppublish SO - Sports Health. 2026 Sep-Oct;18(5):960-968. doi: 10.1177/19417381261431350. Epub 2026 Mar 31. PMID- 41914013 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1943-278X (Electronic) IS - 0363-0234 (Print) IS - 0363-0234 (Linking) VI - 56 IP - 2 DP - 2026 Apr TI - Comparing Objective Measures of Sleep Disturbance and Sleep Related Impairments as Proximal Risk Indicators of Suicidal Intent and Non-Suicidal Self-Injury. PG - e70091 LID - 10.1111/sltb.70091 [doi] LID - e70091 AB - BACKGROUND: Non-suicidal self-injury (NSSI) and suicidal ideation (SI) are prevalent public health concerns among college students. Poor sleep quality and its consequences are a risk factor for NSSI and SI in this population. Unfortunately, limited research measures the impact of sleep related impairment (SRI) on NSSI/SI, little research compares the relative criterion validity of objective versus SRI measurement for NSSI/SI, and there is limited research measuring NSSI behaviors as a primary outcome. METHODS: This study examined the relationship between passively captured Consensus Sleep Diary indices (i.e., actigraphy), SRI, SI, and frequency of NSSI in a sample of N = 132 college-students reporting past-month NSSI/SI. Participants wore actigraphy wristbands during the 28-day daily ambulatory phase and completed self-report assessments each day (k = 3726 observations). RESULTS: Multilevel mixed effects models failed to find significant relationships between actigraphy-derived sleep quality indices, same-day SI and NSSI frequency, and next-day SI and NSSI frequency. Significant relationships between SRI, same-day SI, and same-day NSSI frequency emerged. DISCUSSION: Results suggest worsening SRI may be an important signal of worsening SI and NSSI frequency. Implications for assessment and monitoring of SRI for college students at risk for NSSI and suicide are discussed. CI - (c) 2026 The Author(s). Suicide and Life-Threatening Behavior published by Wiley Periodicals LLC on behalf of American Association of Suicidology. FAU - Oakey-Frost, Nicolas AU - Oakey-Frost N AUID- ORCID: 0000-0001-8365-6045 AD - VA Salt Lake City Healthcare System, Salt Lake City, Utah, USA. FAU - Moscardini, Emma H AU - Moscardini EH AUID- ORCID: 0000-0003-3057-9458 AD - McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA. FAU - Rogers, Megan L AU - Rogers ML AUID- ORCID: 0000-0002-4969-7035 AD - Department of Psychology, Texas State University, San Marcos, Texas, USA. FAU - Muehlenkamp, Jennifer J AU - Muehlenkamp JJ AUID- ORCID: 0000-0003-2653-082X AD - Department of Psychology, University of Wisconsin, Eau Claire, Wisconsin, USA. LA - eng GR - 2R15MH110960/MH/NIMH NIH HHS/United States PT - Comparative Study PT - Journal Article PL - England TA - Suicide Life Threat Behav JT - Suicide & life-threatening behavior JID - 7608054 SB - IM MH - Humans MH - *Self-Injurious Behavior/psychology/diagnosis MH - Female MH - Actigraphy MH - *Suicidal Ideation MH - *Sleep Wake Disorders/psychology/diagnosis MH - Male MH - Young Adult MH - Risk Factors MH - Adolescent MH - Students/psychology MH - Self Report MH - Adult MH - Sleep Quality PMC - PMC13036479 OTO - NOTNLM OT - NSSI OT - actigraphy OT - daily diary OT - passive sensing OT - sleep quality OT - suicidal ideation COIS- The authors declare no conflicts of interest. EDAT- 2026/03/31 06:58 MHDA- 2026/03/31 06:59 PMCR- 2026/03/31 CRDT- 2026/03/31 04:13 PHST- 2026/03/06 00:00 [revised] PHST- 2025/09/13 00:00 [received] PHST- 2026/03/09 00:00 [accepted] PHST- 2026/03/31 06:59 [medline] PHST- 2026/03/31 06:58 [pubmed] PHST- 2026/03/31 04:13 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - SLTB70091 [pii] AID - 10.1111/sltb.70091 [doi] PST - ppublish SO - Suicide Life Threat Behav. 2026 Apr;56(2):e70091. doi: 10.1111/sltb.70091. PMID- 41913715 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260714 IS - 1532-2998 (Electronic) IS - 1532-3005 (Linking) VI - 42 IP - 2 DP - 2026 Apr TI - Heart Rate Variability and Perceived Stress in Normal-Weight Female University Students: The Role of Physical Activity Level. PG - e70167 LID - 10.1002/smi.70167 [doi] AB - Chronic stress, common in university students and particularly pronounced in women, negatively impacts health. Heart Rate Variability (HRV), an autonomic balance measure, is influenced by stress, physical activity (PA), and the menstrual cycle. This study examined HRV and perceived stress differences in healthy-weight female university students by PA level. Fifty-two female university students (18-30 years, BMI 18.5-24.9 kg/m(2)) were recruited. To minimise hormonal variability, assessments for naturally menstruating participants were conducted during the early follicular phase, confirmed through a cycle-tracking application and luteinizing hormone (LH) tests. For participants using hormonal contraceptives, measurements were scheduled during the first week of a new contraceptive cycle. PA was assessed (IPAQ-SF) and categorised as low-moderate or vigorous. HRV was recorded using a Polar H10 over three days for reliability (SDNN, LF, HF, LF/HF ratio) were analysed. Perceived stress used the Perceived Stress Questionnaire (PSQ). Group differences and associations were then analysed, controlling for total PA (METs). Forty-two participants completed the study. Vigorous PA was associated with higher SDNN (p = 0.099, d = -0.620) and lower LF (p = 0.045, d = -0.761) versus the low-moderate PA group, indicating more efficient cardiac autonomic modulation. METs significantly influenced SDNN, HF, LF, and pNN50. However, no significant differences were found in LF/HF ratio (p = 0.990) or perceived stress (p = 0.249) between groups, nor were significant correlations observed between PSQ scores and any HRV indices. Higher PA levels correlate with a more favourable autonomic profile (increased parasympathetic activity, reduced sympathetic drive at rest, unaltered LF/HF balance). The lack of association between PA/perceived stress and perceived stress/HRV suggests a potential dissociation between subjective stress perception and objective autonomic activity in this population. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Santiago, Marta Victoria AU - Santiago MV AUID- ORCID: 0009-0004-0767-6377 AD - Faculty of Health Sciences, European University of the Atlantic, Santander, Spain. FAU - Olmedillas, Hugo AU - Olmedillas H AUID- ORCID: 0000-0003-4625-2759 AD - Department of Functional Biology, Campus del Cristo B, University of Oviedo, Oviedo, Spain. AD - Asturian Research Group in Performance, Readaptation, Training and Health (AstuRES), University of Oviedo, Oviedo, Spain. FAU - Sainz, Julen AU - Sainz J AUID- ORCID: 0009-0002-4993-9994 AD - Faculty of Health Sciences, European University of the Atlantic, Santander, Spain. FAU - Bustillo, Mar AU - Bustillo M AUID- ORCID: 0009-0009-9297-2379 AD - Faculty of Health Sciences, European University of the Atlantic, Santander, Spain. FAU - Heres, Miguel AU - Heres M AUID- ORCID: 0000-0001-5410-8453 AD - Faculty of Health Sciences, European University of the Atlantic, Santander, Spain. FAU - Pulgar, Susana AU - Pulgar S AUID- ORCID: 0000-0002-6845-248X AD - Faculty of Health Sciences, European University of the Atlantic, Santander, Spain. LA - eng GR - Ministerio de Ciencia, Innovacion y Universidades/ PT - Journal Article PL - England TA - Stress Health JT - Stress and health : journal of the International Society for the Investigation of Stress JID - 101089166 SB - IM MH - Humans MH - Female MH - *Heart Rate/physiology MH - Young Adult MH - *Subjective Stress MH - Adult MH - *Students/psychology MH - *Exercise/physiology MH - Adolescent MH - Universities MH - *Autonomic Nervous System/physiology MH - Menstrual Cycle/physiology MH - *Stress, Psychological/physiopathology OTO - NOTNLM OT - exercise OT - heart rate variability OT - stress response OT - women OT - young adults EDAT- 2026/03/31 07:00 MHDA- 2026/03/31 07:01 CRDT- 2026/03/31 03:53 PHST- 2026/01/20 00:00 [revised] PHST- 2025/09/04 00:00 [received] PHST- 2026/03/04 00:00 [accepted] PHST- 2026/03/31 07:01 [medline] PHST- 2026/03/31 07:00 [pubmed] PHST- 2026/03/31 03:53 [entrez] AID - 10.1002/smi.70167 [doi] PST - ppublish SO - Stress Health. 2026 Apr;42(2):e70167. doi: 10.1002/smi.70167. PMID- 41913168 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1472-6823 (Electronic) IS - 1472-6823 (Linking) VI - 26 IP - 1 DP - 2026 Mar 30 TI - Association between the Chinese visceral adiposity index and thyroid nodule risk: a retrospective analysis of cross-sectional, case-control, and cohort studies. LID - 10.1186/s12902-026-02240-y [doi] LID - 130 AB - BACKGROUND: With the increasing use of ultrasound, the detection rate of thyroid nodules (TNs) has risen markedly in recent years. However, the relationship between obesity and TNs remains controversial. This study aimed to investigate the association between the Chinese visceral adiposity index (CVAI), a novel obesity indicator, and the risk of TNs. METHODS: A multi-design study was conducted among individuals aged 18-80 years who underwent periodic health examinations in Suzhou, China, from 2020 to 2024. The discovery stage comprised cross-sectional and case-control analyses to examine associations between CVAI and TN risk. The validation stage involved a prospective cohort study evaluating the predictive role of CVAI in incident TNs. Multivariable logistic regression and Cox proportional hazards models were applied. RESULTS: The cross-sectional study included 83,757 participants, and the case-control study included 31,035 matched pairs. The median age was 40.59 and 39.28 years, respectively. Each standard deviation increase in CVAI was significantly associated with an increased risk of TN [cross-sectional: odds ratio (OR) = 1.19, 95% confidence interval (95% CI): 1.16-1.22; case-control: OR = 1.24, 95% CI: 1.20-1.27]. The cohort study including 18,110 participants validated the association [hazard ratio (HR) = 1.12, 95% CI: 1.07-1.18]. Restricted cubic spline analyses demonstrated a nonlinear dose-response relationship, with a steep rise in TN risk at higher CVAI levels. Subgroup analyses revealed stronger associations in females, individuals with lower body mass index (BMI), those who engaged in regular exercise, and participants without dyslipidemia. CONCLUSION: Elevated CVAI was significantly associated with an increased risk of TNs. These findings provided new insights for scientific management and prevention of TNs, highlighting the potential value of CVAI in health management. FAU - Tian, Ting AU - Tian T AD - Central Research Laboratory, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, 210042, China. FAU - Han, Renfang AU - Han R AD - Health Management Center, Suzhou Municipal Hospital, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Nanjing Medical University, Suzhou, 215008, China. FAU - Zhou, Quan AU - Zhou Q AD - Health Management Center, Suzhou Municipal Hospital, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Nanjing Medical University, Suzhou, 215008, China. FAU - Li, Yuanli AU - Li Y AD - Health Management Center, Suzhou Municipal Hospital, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Nanjing Medical University, Suzhou, 215008, China. FAU - Wang, Yi AU - Wang Y AD - Health Management Center, Suzhou Municipal Hospital, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Nanjing Medical University, Suzhou, 215008, China. FAU - Zeng, Nimei AU - Zeng N AD - Health Management Center, Suzhou Municipal Hospital, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Nanjing Medical University, Suzhou, 215008, China. FAU - Xie, Fangfei AU - Xie F AD - Health Management Center, Suzhou Municipal Hospital, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Nanjing Medical University, Suzhou, 215008, China. FAU - Wang, Yun AU - Wang Y AD - Health Management Center, Suzhou Municipal Hospital, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Nanjing Medical University, Suzhou, 215008, China. FAU - Zhong, Chenyi AU - Zhong C AD - Center for Human Reproduction and Genetics, Suzhou Municipal Hospital, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Nanjing Medical University, Suzhou, 215002, China. zhongchenyi0702@163.com. AD - The Affiliated Suzhou Hospital of Nanjing Medical University, No. 26, Daoqian Road, Gusu District, Suzhou, Jiangsu Province, China. zhongchenyi0702@163.com. FAU - Fan, Jingyi AU - Fan J AD - Health Management Center, Suzhou Municipal Hospital, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Nanjing Medical University, Suzhou, 215008, China. fanjingyi@njmu.edu.cn. AD - The Affiliated Suzhou Hospital of Nanjing Medical University, No. 242, Guangji Road, Gusu District, Suzhou, Jiangsu Province, China. fanjingyi@njmu.edu.cn. LA - eng GR - SYW2024112/Suzhou Applied Basic Research (Medical and Health) Technology Innovation Project/ GR - SYWD2024144/Suzhou Applied Basic Research (Medical and Health) Technology Innovation Project/ GR - BK20220258/Natural Science Foundation of the Jiangsu Provincial Science and Technology/ GR - GSWS2023109/Gusu Health Talent Plan Talent Research Project/ PT - Journal Article DEP - 20260330 PL - England TA - BMC Endocr Disord JT - BMC endocrine disorders JID - 101088676 RN - Chinese people SB - IM MH - Humans MH - Female MH - *Thyroid Nodule/epidemiology/etiology MH - Cross-Sectional Studies MH - Case-Control Studies MH - Adult MH - Middle Aged MH - China/epidemiology MH - Male MH - Retrospective Studies MH - Risk Factors MH - Young Adult MH - *Obesity, Abdominal/complications/epidemiology MH - Adolescent MH - *Intra-Abdominal Fat MH - Aged MH - Follow-Up Studies MH - Prognosis MH - Aged, 80 and over MH - Body Mass Index MH - East Asian People PMC - PMC13154479 OTO - NOTNLM OT - Intra-abdominal fat OT - Physical examination OT - Risk factors OT - Thyroid nodule COIS- Declarations. Ethics approval and consent to participate: All research was conducted in accordance with both the Declarations of Helsinki and Istanbul. The Periodic Health Examination project was approved by the Ethics Committee of the Affiliated Suzhou Hospital of Nanjing Medical University (Ethical Approval Number: K-2022-105-K01). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/31 06:59 MHDA- 2026/06/28 00:36 PMCR- 2026/03/30 CRDT- 2026/03/31 00:09 PHST- 2025/12/01 00:00 [received] PHST- 2026/03/18 00:00 [accepted] PHST- 2026/06/28 00:36 [medline] PHST- 2026/03/31 06:59 [pubmed] PHST- 2026/03/31 00:09 [entrez] PHST- 2026/03/30 00:00 [pmc-release] AID - 10.1186/s12902-026-02240-y [pii] AID - 2240 [pii] AID - 10.1186/s12902-026-02240-y [doi] PST - epublish SO - BMC Endocr Disord. 2026 Mar 30;26(1):130. doi: 10.1186/s12902-026-02240-y. PMID- 41912617 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Mar 30 TI - Acute physical activity supports inhibitory control in primary school children: a randomised cross-over trial. LID - 10.1038/s41598-026-44375-x [doi] LID - 10647 AB - Studies have found inconsistent results regarding the acute effects of physical activity on inhibitory control in children. More naturalistic studies that have real-world validity and use objective measures of physical activity are essential. This study investigated the acute effects of a pre-existing school-based group physical activity session on inhibitory control. Fifty-five primary school children (9 +/- 1 years old, 40% female) participated in a pre-existing school-based group physical activity session and a sedentary poster-making control condition, both lasting approximately 30 min, in a randomised, cross-over manner. Cognitive tasks were completed before and after both conditions, and measures of performance on these tasks were used as dependent variables in all analyses. Time engaged in moderate-to-vigorous physical activity during each condition was measured by accelerometry and used as a manipulation check. After physical activity there were faster reaction times (beta = -176, 95%CI: -296.43, -59.51) and more commission errors (beta = 1.06, 95%CI: 0.18, 1.95) in the simple reaction time task, but fewer commission errors (beta = -4.64, 95%CI: -9.00 -0.28) in the inhibition task compared to the control condition. Using the same statistical approach, a supplementary analysis was run on a reduced sample of 32 (9 +/- 1 years old, 44% female) whose adherence to conditions was confirmed by accelerometry. Results showed faster reaction times (beta = -205, 95%CI: -384.58, -33.37) in the simple reaction time task and fewer commission errors (beta = -6.10, 95%CI: -11.75, -0.45) in the inhibition task following physical activity. This suggests that an acute bout of physical activity facilitates inhibitory control in primary school children. Optimal effects are seen when participants achieved higher intensity physical activity during the intervention. FAU - Watson, Evelyn AU - Watson E AD - Institute of Sport Exercise and Health, Faculty of Medical Sciences, University College London, London, UK. evelyn.watson.22@ucl.ac.uk. AD - Institute of Cognitive Neuroscience, Faculty of Brain Sciences, University College London, London, UK. evelyn.watson.22@ucl.ac.uk. FAU - Burgess, Paul W AU - Burgess PW AD - Institute of Cognitive Neuroscience, Faculty of Brain Sciences, University College London, London, UK. FAU - Metcalf, Isabel AU - Metcalf I AD - Institute of Sport Exercise and Health, Faculty of Medical Sciences, University College London, London, UK. FAU - Hamer, Mark AU - Hamer M AD - Institute of Sport Exercise and Health, Faculty of Medical Sciences, University College London, London, UK. FAU - Ronca, Flaminia AU - Ronca F AD - Institute of Sport Exercise and Health, Faculty of Medical Sciences, University College London, London, UK. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260330 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Child MH - *Exercise/physiology MH - Cross-Over Studies MH - Schools MH - Male MH - Reaction Time/physiology MH - Accelerometry MH - Cognition/physiology MH - *Inhibition, Psychological PMC - PMC13039183 COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/03/31 00:53 MHDA- 2026/06/28 16:09 PMCR- 2026/03/30 CRDT- 2026/03/30 23:20 PHST- 2025/02/10 00:00 [received] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/06/28 16:09 [medline] PHST- 2026/03/31 00:53 [pubmed] PHST- 2026/03/30 23:20 [entrez] PHST- 2026/03/30 00:00 [pmc-release] AID - 10.1038/s41598-026-44375-x [pii] AID - 44375 [pii] AID - 10.1038/s41598-026-44375-x [doi] PST - epublish SO - Sci Rep. 2026 Mar 30;16(1):10647. doi: 10.1038/s41598-026-44375-x. PMID- 41911587 OWN - NLM STAT- Publisher LR - 20260330 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) DP - 2026 Mar 30 TI - The Effects of Adenoidectomy on Children's Eating Patterns, Sleep, and Weight Gain: A Case-Control Study. LID - 10.1097/SCS.0000000000012689 [doi] AB - OBJECTIVE: The purpose of this study is to determine whether children who undergo adenoidectomy show statistically significant improvements in their eating habits, sleep quality, and weight gain. METHODS: Fifty individuals who had undergone adenoidectomy and 50 healthy controls matched for age and sex were included in the case-control study. The Eating Improvement Score, Sleep Quality Score, and Weight Gain Rate were assessed using standardized anthropometric measurements and validated parent-reported scales. RESULTS: Patients who underwent adenoidectomy had considerably higher rates of weight gain (0.74 versus 0.28 kg/mo), Eating Improvement Scores (7.7 versus 4.4), and Sleep Quality Scores (7.8 versus 4.5). CONCLUSION: Nutritional and functional outcomes are significantly improved after adenoidectomy in children with adenoid hypertrophy, demonstrating that the procedure has benefits beyond clear airways. CI - Copyright (c) 2026 by Mutaz B. Habal, MD. FAU - Arslanoglu, Ahmet AU - Arslanoglu A AD - ENT Specialist, Private Practice, Istanbul. FAU - Yazir, Mustafa AU - Yazir M AD - Yazir Private Otorhinolaryngology Clinic, Izmir. FAU - Yagci, Tarik AU - Yagci T AD - Department of Otorhinolaryngology, Medical Faculty, Bilecik Seyh Edebali University, Bilecik. FAU - Bariskan, Serkan AU - Bariskan S AD - ENT Specialist, Private Practice, Istanbul. FAU - Topan, Yunus E AU - Topan YE AD - Department of Otorhinolaryngology, Medical Faculty, Usak University, Usak, Turkiye. LA - eng PT - Journal Article DEP - 20260330 PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 SB - IM OTO - NOTNLM OT - Adenoidectomy OT - The Eating Improvement Score OT - sleep quality score OT - weight gain rate COIS- The authors report no conflicts of interest. EDAT- 2026/03/30 18:30 MHDA- 2026/03/30 18:30 CRDT- 2026/03/30 17:23 PHST- 2026/02/10 00:00 [received] PHST- 2026/03/01 00:00 [accepted] PHST- 2026/03/30 18:30 [medline] PHST- 2026/03/30 18:30 [pubmed] PHST- 2026/03/30 17:23 [entrez] AID - 00001665-990000000-03908 [pii] AID - 10.1097/SCS.0000000000012689 [doi] PST - aheadofprint SO - J Craniofac Surg. 2026 Mar 30. doi: 10.1097/SCS.0000000000012689. PMID- 41910786 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260921 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 4 DP - 2026 Mar 30 TI - Validation of an enhanced pediatric vitamin D deficiency score incorporating sun exposure timing and BMI z-score: analysis in a combined cohort of children. LID - 10.1007/s00431-026-06890-x [doi] LID - 226 AB - Early identification of vitamin D (VitD) deficiency in childhood is essential to support timely prevention and intervention strategies. Building on the previously validated pediatric EVIDENCe-Q questionnaire, this study aimed to refine the tool by integrating two patient-specific weighted variables, sun exposure during peak UVB hours, and BMI z-score categories, both recognized determinants of circulating 25-hydroxyvitamin D (25-OH-D) levels. A total of 354 children (190F/164 M) completed a 20-item pediatric VitD risk questionnaire. Serum 25-OH-D concentrations were available for 280 participants. Three scoring algorithms were evaluated: the unweighted standard model, the sun-weighted model, and the sun + BMI-weighted model. Statistical analyses included ANOVA, Pearson correlations, and receiver operating characteristic (ROC) analyses across biochemical thresholds of vitamin D deficiency and insufficiency (< 10, < 20, and < 30 ng/mL). Vitamin D deficiency (< 10 ng/mL) was observed in 6.8% of participants, while insufficiency affected 38.1% (< 20 ng/mL) and 74.7% (< 30 ng/mL). The unweighted standard model did not discriminate among vitamin D categories (p = 0.622). In contrast, both weighted models showed significant discrimination (sun-weighted: p = 0.036; sun + BMI-weighted: p = 0.030). Only the sun + BMI-weighted model was significantly correlated with serum 25-OH-D levels (r = - 0.13; p = 0.023). ROC analyses demonstrated limited accuracy for the unweighted model, whereas the weighted models showed moderate discriminatory ability, with the Sun + BMI-Weighted Model providing the strongest overall performance. CONCLUSIONS: Incorporating weighted patient-specific variables improves the discriminatory capacity of the pediatric EVIDENCe-Q. Despite moderate accuracy, particularly at lower thresholds, the refined questionnaire, especially the sun + BMI-weighted version, represents a practical, noninvasive screening tool to identify children at risk of hypovitaminosis D. WHAT IS KNOWN: * Vitamin D deficiency is highly prevalent in children worldwide, even in sun-rich regions, and is influenced by factors such as sun exposure and adiposity. * Serum 25-OH-D measurement is the diagnostic gold standard, while questionnaire-based tools offer a non-invasive but currently less accurate alternative in pediatrics. WHAT IS NEW: * Incorporating weighted factors for peak UVB sun exposure and BMI z-score signifi cantly improves the predictive performance of the pediatric EVIDENCe-Q. * The Sun + BMI-weighted model shows a significant correlation with serum 25-OH-D and enhances identification of children at risk of hypovitaminosis D (30 ng/mL). CI - (c) 2026. The Author(s). FAU - Calcaterra, Valeria AU - Calcaterra V AD - Department of Internal Medicine and Therapeutics, University of Pavia, 27100, Pavia, Italy. valeria.calcaterra@unipv.it. AD - Pediatric Department, Buzzi Children's Hospital, 20154, Milan, Italy. valeria.calcaterra@unipv.it. FAU - Cena, Hellas AU - Cena H AD - Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100, Pavia, Italy. hellas.cena@unipv.it. AD - Clinical Nutrition Unit, ICS Maugeri IRCCS, 27100, Pavia, Italy. hellas.cena@unipv.it. FAU - Biino, Ginevra AU - Biino G AD - Institute of Molecular Genetics, National Research Council of Italy, 27100, Pavia, Italy. FAU - Scavone, Ilaria Anna Maria AU - Scavone IAM AD - Pediatric Department, Buzzi Children's Hospital, 20154, Milan, Italy. FAU - Vincenti, Alessandra AU - Vincenti A AD - Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100, Pavia, Italy. FAU - Zuccotti, Gianvincenzo AU - Zuccotti G AD - Pediatric Department, Buzzi Children's Hospital, 20154, Milan, Italy. AD - Department of Biomedical and Clinical Science, University of Milano, 20157, Milan, Italy. LA - eng GR - Project 101128946/PODiaCar-EU4H-2022-PJ-3 co-funded by European Union./ GR - CUP F13C22001210007/National Recovery and resilience Plan (NRRP), Mission 4 Component 2 Investment 1.3-Call for proposal No. 341 of 15 March 2022 of Italian Ministry of University and Research funded by the European Union-NextGenerationEU/ PT - Journal Article PT - Validation Study DEP - 20260330 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) SB - IM MH - Humans MH - *Vitamin D Deficiency/diagnosis/blood/epidemiology MH - Female MH - Male MH - Child MH - *Body Mass Index MH - *Sunlight MH - *Vitamin D/blood/analogs & derivatives MH - Surveys and Questionnaires MH - Child, Preschool MH - ROC Curve MH - Adolescent MH - Algorithms PMC - PMC13035619 OTO - NOTNLM OT - BMI z-score OT - Children OT - Pediatrics OT - Questionnaire OT - Sun exposure timing OT - Vitamin D deficiency COIS- Declarations. Ethics approval: The protocol received approval from the Institutional Review Board of the hospital (Ethics Committee Milano Area 1; Study Registration 2020/ST/234; Protocol No. 0030785). The study was conducted in full accordance with the ethical principles of the Declaration of Helsinki and with current Italian regulations on biomedical research involving minors. Consent to participate: Before participation, written informed consent was obtained from all parents or legal guardians after providing a comprehensive explanation of the study's purpose, procedures, potential risks, and expected benefits. When appropriate, assent was also obtained from older children and adolescents. Confidentiality and data protection were ensured by anonymizing all clinical and questionnaire data prior to analysis. Competing interests: The authors declare no competing interests. EDAT- 2026/03/30 12:50 MHDA- 2026/03/30 12:51 PMCR- 2026/03/30 CRDT- 2026/03/30 11:14 PHST- 2025/12/22 00:00 [received] PHST- 2026/03/21 00:00 [accepted] PHST- 2026/03/11 00:00 [revised] PHST- 2026/03/30 12:51 [medline] PHST- 2026/03/30 12:50 [pubmed] PHST- 2026/03/30 11:14 [entrez] PHST- 2026/03/30 00:00 [pmc-release] AID - 10.1007/s00431-026-06890-x [pii] AID - 6890 [pii] AID - 10.1007/s00431-026-06890-x [doi] PST - epublish SO - Eur J Pediatr. 2026 Mar 30;185(4):226. doi: 10.1007/s00431-026-06890-x. PMID- 41910540 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1558-9110 (Electronic) IS - 1058-0360 (Print) IS - 1058-0360 (Linking) VI - 35 IP - 3 DP - 2026 May 5 TI - Concurrent Use of Videofluoroscopic and Nutritional Intake Measures in the Assessment of Pediatric Patients With Dysphagia: A Scoping Review. PG - 1360-1379 LID - 10.1044/2026_AJSLP-25-00462 [doi] AB - INTRODUCTION: The videofluoroscopic swallowing study (VFSS) is a radiographic procedure that assesses swallowing physiology in real time by visualizing bolus flow in coordination with structural movement throughout the upper aerodigestive tract. Nutritional intake measures are intended to identify restrictions placed on a patient's method of nutritional intake. There is a lack of rigorous evidence to inform recommendations about appropriate and adequate means of nutritional intake. The purpose of this scoping review was to explore the type and validity of nutritional intake measures and how they are used with VFSS findings to inform nutritional intake recommendations by speech-language pathologists in children (birth to 17 years of age) with dysphagia. METHOD: A comprehensive search of the literature was completed in accordance with the Joanna Briggs Institute methodological recommendations and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Reviews reporting guidelines. Relevant electronic databases and gray literature were searched without any date restrictions. Reviewers were blinded via Rayyan software. Data were extracted using a data extraction tool created by the research team. RESULTS: Twenty articles met inclusion and exclusion criteria and were included for review. Articles included were from eight different countries, published between the years 2010 and 2024, and included a variety of patient populations and objectives. VFSS administration and nutritional intake measure usage were variable, with fluctuating levels of validity. DISCUSSION: At present, there is no one nutritional intake measure that is consistently administered to all pediatric populations jointly with VFSS administration. The current investigation only looked at nutritional intake measures used jointly with VFSS. Other nutritional intake measures exist and are worth exploring as potential assessment options in clinical practice. CONCLUSION: There is an evident need for the development of nutritional intake measures with strong validity and reliability that consider physiologic impairments observed during VFSS to inform clinical recommendations. FAU - Kiemel, Zoe AU - Kiemel Z AUID- ORCID: 0009-0002-2252-8335 AD - Department of Communication Sciences and Disorders, School of Communication, Northwestern University, Evanston, IL. FAU - Kruse, Jason AU - Kruse J AD - Northwestern University Library, Northwestern University, Evanston, IL. FAU - Smith, Rebecca AU - Smith R AD - Department of Communication Sciences and Disorders, School of Communication, Northwestern University, Evanston, IL. FAU - McGhee, Heather AU - McGhee H AD - Department of Communication Sciences and Disorders, School of Communication, Northwestern University, Evanston, IL. AD - Department of Speech-Language Pathology, Medical University of South Carolina, Charleston. FAU - Adams, Steven M AU - Adams SM AD - Northwestern University Library, Northwestern University, Evanston, IL. FAU - Wintermute, Paige AU - Wintermute P AD - Department of Communication Sciences and Disorders, School of Communication, Northwestern University, Evanston, IL. FAU - Daul, Kendal AU - Daul K AD - Department of Communication Sciences and Disorders, School of Communication, Northwestern University, Evanston, IL. FAU - Bekas, Stephanie AU - Bekas S AD - Department of Communication Sciences and Disorders, School of Communication, Northwestern University, Evanston, IL. FAU - van den Berg, Nadia AU - van den Berg N AD - Department of Communication Sciences and Disorders, School of Communication, Northwestern University, Evanston, IL. FAU - Martin-Harris, Bonnie AU - Martin-Harris B AUID- ORCID: 0000-0001-7840-3764 AD - Department of Communication Sciences and Disorders, School of Communication, Northwestern University, Evanston, IL. AD - Department of Faculty Affairs, School of Communication, Northwestern University, Evanston, IL. AD - Departments of Otolaryngology-Head & Neck Surgery and Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260327 PL - United States TA - Am J Speech Lang Pathol JT - American journal of speech-language pathology JID - 9114726 SB - IM MH - Humans MH - *Deglutition Disorders/physiopathology/diagnostic imaging/diagnosis MH - Child MH - Infant MH - Fluoroscopy/methods MH - Child, Preschool MH - *Deglutition/physiology MH - Adolescent MH - Reproducibility of Results MH - *Nutrition Assessment MH - Video Recording MH - Infant, Newborn MH - Speech-Language Pathology/methods PMC - PMC13151574 EDAT- 2026/03/30 12:49 MHDA- 2026/05/05 18:32 PMCR- 2026/03/27 CRDT- 2026/03/30 10:33 PHST- 2026/05/05 18:32 [medline] PHST- 2026/03/30 12:49 [pubmed] PHST- 2026/03/30 10:33 [entrez] PHST- 2026/03/27 00:00 [pmc-release] AID - 23814764000300140072 [pii] AID - 10.1044/2026_AJSLP-25-00462 [doi] PST - ppublish SO - Am J Speech Lang Pathol. 2026 May 5;35(3):1360-1379. doi: 10.1044/2026_AJSLP-25-00462. Epub 2026 Mar 27. PMID- 41909584 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260330 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Stress, well-being, and optimism in Portuguese youth: how do gender and age shape mental health and eating quality. PG - 1593283 LID - 10.3389/fpsyg.2026.1593283 [doi] LID - 1593283 AB - Stress has been consistently linked to changes in eating behaviors and psychological well-being among adolescents and young adults, yet evidence remains fragmented regarding how gender, developmental stage, and psychological resources jointly shape these outcomes. Grounded in stress-coping models, self-regulation theories, and a life-span developmental perspective, this study examines age- and gender-related differences in stress, well-being, optimism, and eating quality within a post-lockdown context. A cross-sectional study was conducted with 951 Portuguese adolescents and young adults aged 15-26 years. Data were collected across three post-lockdown periods (2020-2022) and aggregated after confirming negligible time-related effects (eta (2) /=18 years) with biopsy- or serology-confirmed CeD (n = 233). The questionnaire collected sociodemographic and clinical data, assessed adherence using the Celiac Dietary Adherence Test (CDAT; good < 13, poor >/= 13), and measured perceptions of home and supply food environments via the adapted NEMS-P-GF. Construct validity was tested using exploratory factor analysis and reliability with Cronbach's alpha and McDonald's omega. Associations with adherence were analyzed using Mann-Whitney U. Results: NEMS-P-GF domains showed adequate validity (KMO 0.71-0.81; Bartlett's p < 0.001) and acceptable-to-excellent reliability (alpha/omega = 0.70-0.90). Participants with good vs. poor adherence perceived more supportive environments, particularly at home (median 4.79 vs. 1.29; p < 0.01) and globally (1.72 vs. -7.25; p < 0.01). Supply environments were perceived as less supportive due to limited availability and high prices (median -3.68 and -7.78), with smaller differences between adherence groups (p = 0.018). Conclusions: Supportive home environments were strongly associated with better GFD adherence, while supply environments remained broadly restrictive, showing modest but significant differences between adherence groups. The NEMS-P-GF demonstrated preliminary evidence of good psychometric properties and offers a valid, context-sensitive tool to assess GF food environments and inform public health strategies for CeD populations. FAU - Vega-Salas, Maria Jesus AU - Vega-Salas MJ AUID- ORCID: 0000-0002-5798-7091 AD - Departamento de Nutricion y Dietetica, Escuela de Ciencias de la Salud, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago 7820436, Chile. AD - Center for Cancer Prevention and Control (CECAN), Santiago 7820436, Chile. FAU - Parada, Alejandra AU - Parada A AUID- ORCID: 0000-0001-9573-2957 AD - Departamento de Nutricion y Dietetica, Escuela de Ciencias de la Salud, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago 7820436, Chile. AD - Departamento de Nutricion, Diabetes y Metabolismo, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago 7820436, Chile. FAU - Hermosilla-Llanca, Danae AU - Hermosilla-Llanca D AUID- ORCID: 0009-0008-0128-534X AD - Departamento de Nutricion y Dietetica, Escuela de Ciencias de la Salud, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago 7820436, Chile. FAU - Berkowitz, Loni AU - Berkowitz L AUID- ORCID: 0000-0002-8562-4845 AD - Departamento de Nutricion, Diabetes y Metabolismo, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago 7820436, Chile. AD - Centro de Nutricion Molecular y Enfermedades Cronicas, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago 8331010, Chile. FAU - Rodriguez Osiac, Lorena AU - Rodriguez Osiac L AUID- ORCID: 0000-0002-7732-2580 AD - Center for Cancer Prevention and Control (CECAN), Santiago 7820436, Chile. AD - Escuela de Salud Publica Dr. Salvador Allende, Universidad de Chile, Santiago 8380453, Chile. FAU - Egana Rojas, Daniel AU - Egana Rojas D AUID- ORCID: 0000-0001-7877-0513 AD - Departamento de Atencion Primaria y Salud Familiar, Facultad de Medicina, Universidad de Chile, Santiago 8900085, Chile. FAU - Rigotti, Attilio AU - Rigotti A AUID- ORCID: 0000-0002-0495-3525 AD - Departamento de Nutricion, Diabetes y Metabolismo, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago 7820436, Chile. AD - Centro de Nutricion Molecular y Enfermedades Cronicas, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago 8331010, Chile. LA - eng GR - Concurso Interdisciplinario de Investigacion Escuela de Medicina y Departamento de Ciencias de la Salud 2023/Pontificia Universidad Catolica de Chile/ PT - Journal Article PT - Validation Study DEP - 20260316 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Celiac Disease/diet therapy/psychology MH - *Diet, Gluten-Free/psychology MH - Chile MH - Female MH - Adult MH - Male MH - *Patient Compliance/statistics & numerical data/psychology MH - Cross-Sectional Studies MH - Middle Aged MH - Reproducibility of Results MH - Young Adult MH - Surveys and Questionnaires MH - Adolescent MH - *Nutrition Surveys PMC - PMC13028700 OTO - NOTNLM OT - celiac disease OT - dietary adherence OT - food environments OT - gluten-free diet OT - structural determinants of diet COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analysis, or interpretation of data, in the writing of the manuscript, or in the decision to publish the results. EDAT- 2026/03/28 06:40 MHDA- 2026/03/28 06:41 PMCR- 2026/03/16 CRDT- 2026/03/28 01:31 PHST- 2025/12/17 00:00 [received] PHST- 2026/01/30 00:00 [revised] PHST- 2026/02/05 00:00 [accepted] PHST- 2026/03/28 06:41 [medline] PHST- 2026/03/28 06:40 [pubmed] PHST- 2026/03/28 01:31 [entrez] PHST- 2026/03/16 00:00 [pmc-release] AID - nu18060929 [pii] AID - nutrients-18-00929 [pii] AID - 10.3390/nu18060929 [doi] PST - epublish SO - Nutrients. 2026 Mar 16;18(6):929. doi: 10.3390/nu18060929. PMID- 41901070 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 6 DP - 2026 Mar 12 TI - Development and Evaluation of a Functional Food Consumption Index (FunFoCI) in Adults. LID - 10.3390/nu18060895 [doi] LID - 895 AB - BACKGROUND/OBJECTIVES: Functional foods are widely discussed in nutrition research, yet their consumption is rarely quantified using a standardized, food-based metric. We developed the Functional Food Consumption Index (FunFoCI) and conducted an initial evaluation of its performance in adults. METHODS: In this cross-sectional study, 500 adults (>/=18 years, 286 women, 214 men) were assessed using a 210-item quantitative food frequency questionnaire (FFQ) and a 3 day food record (FR). Candidate index foods were evaluated by five experts, using a 4-point Likert scale to establish content validity, and the finalized FunFoCI comprised 100 foods across nine groups: fruits; vegetables; whole grains; legumes; nuts and oilseeds; fermented foods and products; animal-based foods; functional oils; and spices, herbal teas, and functional beverages. FunFoCI scoring used a sample distribution-based percentile approach, including modifications for zero-inflated or sparsely consumed items, followed by group-level normalization (0-1), equal weighting across nine groups, and rescaling to 0-100. FR data were used to examine the between-method feasibility of the scoring approach. The convergent validity was assessed via correlation analyses, with the Diet Quality Index-International (DQI-I) and Healthy Eating Index-2015 (HEI-2015) derived from both FFQ and FR data, and additional correlation analyses and robustness checks were conducted to examine associations among key study variables. Known group patterns were examined across sociodemographic, lifestyle, and anthropometric characteristics. RESULTS: Content evaluation supported index coverage (S-CVI/Ave = 0.912; S-CVI/UA = 0.877; mean modified kappa = 0.899). The mean FunFoCI total scores were 32.68 +/- 11.92 (FFQ) and 13.29 +/- 4.65 (FR). Participants were classified into low (32.8%, n = 164), moderate (33.0%, n = 165), and high (34.2%, n = 171) FunFoCI categories. FunFoCI correlated with FFQ-derived DQI-I and HEI-2015 (r = 0.367 and r = 0.368; both p < 0.001), and both indices increased across ascending FunFoCI total scores (p < 0.001). The FFQ-derived FunFoCI total score was correlated with the FR-derived FunFoCI score (r = 0.294; p < 0.001). FunFoCI scores showed differences across participant sociodemographic, lifestyle and anthropometric characteristics. CONCLUSIONS: FunFoCI is a newly developed, expert-reviewed, food-based index with transparent, sample distribution-based scoring and normalized aggregation. Its initial evaluation supports its use for the standardized quantification of relative functional food consumption in adults, while further studies should assess the reliability and external validation criteria in other populations and study designs. FAU - Arman, Gulden AU - Arman G AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Artvin Coruh University, Artvin 08000, Turkey. AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Ankara 06100, Turkey. FAU - Akyol, Asli AU - Akyol A AUID- ORCID: 0000-0001-6301-6358 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Ankara 06100, Turkey. LA - eng PT - Journal Article DEP - 20260312 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Adult MH - Male MH - Cross-Sectional Studies MH - *Functional Food MH - Middle Aged MH - Reproducibility of Results MH - Young Adult MH - Diet Records MH - *Diet, Healthy MH - *Diet Surveys MH - Feeding Behavior MH - Adolescent MH - Surveys and Questionnaires PMC - PMC13029523 OTO - NOTNLM OT - diet quality index-international (DQI-I) OT - food frequency questionnaire (FFQ) OT - functional food consumption index (FunFoCI) OT - functional foods OT - healthy eating index-2015 (HEI-2015) COIS- The authors declare no conflicts of interest. EDAT- 2026/03/28 06:39 MHDA- 2026/03/28 06:40 PMCR- 2026/03/12 CRDT- 2026/03/28 01:31 PHST- 2026/01/28 00:00 [received] PHST- 2026/03/02 00:00 [revised] PHST- 2026/03/09 00:00 [accepted] PHST- 2026/03/28 06:40 [medline] PHST- 2026/03/28 06:39 [pubmed] PHST- 2026/03/28 01:31 [entrez] PHST- 2026/03/12 00:00 [pmc-release] AID - nu18060895 [pii] AID - nutrients-18-00895 [pii] AID - 10.3390/nu18060895 [doi] PST - epublish SO - Nutrients. 2026 Mar 12;18(6):895. doi: 10.3390/nu18060895. PMID- 41899775 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 23 IP - 3 DP - 2026 Mar 20 TI - A Bifactor Measure of Societal Stigma Toward Eating Disorders and Obesity: Scale Development and Validation. LID - 10.3390/ijerph23030399 [doi] LID - 399 AB - BACKGROUND: Societal stigma toward eating disorders and obesity remains pervasive and is associated with psychological distress, maladaptive eating behaviors, reduced help-seeking, and barriers to care. Despite its documented impact, comprehensive and psychometrically robust instruments to assess stigma-particularly in Spanish-speaking populations-are scarce. This study aimed to develop and validate a multidimensional measure of societal stigma toward eating disorders and obesity in Spain, grounded in contemporary stigma frameworks. METHODS: A cross-sectional observational study was conducted in a large community sample recruited online (N = 2121). An initial pool of stigma-related items was developed based on theoretical and empirical literature and refined through expert content validation. Psychometric evaluation included item screening, exploratory factor analysis (EFA), confirmatory factor analysis (CFA), bifactor modeling, and reliability assessment. The sample was randomly split for EFA (n = 988) and CFA (n = 658). Associations between stigma scores and sociodemographic and experiential variables were examined. RESULTS: The final 36-item instrument demonstrated excellent psychometric properties. Bifactor analyses supported an essentially unidimensional structure dominated by a strong general stigma factor, with secondary content-specific dimensions (e.g., legitimacy, personal responsibility, visibility, and treatment beliefs). The theory-driven bifactor model showed excellent fit (CFI = 0.991; TLI = 0.990; RMSEA = 0.024). The general factor exhibited high reliability (omega(h) = 0.87). Higher stigma was observed among men, older participants, and individuals without personal or familial experience of eating disorders or obesity. CONCLUSIONS: This study provides a reliable and theoretically grounded instrument for assessing societal stigma toward eating disorders and obesity in Spain. The scale enables systematic research on stigma and offers a valuable tool for public health surveillance, intervention development, and evaluation of anti-stigma initiatives aimed at promoting compassionate and equitable care. FAU - Suso-Ribera, Carlos AU - Suso-Ribera C AD - Rheumatology Research Group, Vall d'Hebron Research Institute, 08035 Barcelona, Spain. AD - Faculty of Health Sciences, Universidad Europea de Canarias, 38300 La Orotava, Spain. FAU - Diaz-Sanahuja, Laura AU - Diaz-Sanahuja L AD - Faculty of Psychology and Speech Therapy, Universidad de Valencia, 46010 Valencia, Spain. FAU - Paredes-Mealla, Macarena AU - Paredes-Mealla M AD - Hospital Provincial Foundation, 12006 Castellon, Spain. FAU - Marsal, Sara AU - Marsal S AD - Rheumatology Research Group, Vall d'Hebron Research Institute, 08035 Barcelona, Spain. AD - Department of Rheumatology, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain. FAU - Almirall, Miriam AU - Almirall M AUID- ORCID: 0000-0002-4874-8013 AD - Rheumatology Research Group, Vall d'Hebron Research Institute, 08035 Barcelona, Spain. AD - Department of Rheumatology, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain. LA - eng PT - Journal Article PT - Observational Study PT - Validation Study DEP - 20260320 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - *Feeding and Eating Disorders/psychology MH - *Obesity/psychology MH - *Social Stigma MH - Psychometrics MH - Spain MH - Male MH - Cross-Sectional Studies MH - Female MH - Adult MH - Middle Aged MH - Factor Analysis, Statistical MH - Reproducibility of Results MH - Surveys and Questionnaires MH - Young Adult MH - Adolescent PMC - PMC13026928 OTO - NOTNLM OT - eating disorders OT - obesity OT - psychometric validation OT - scale development OT - stigma COIS- The authors declare no conflicts of interest. EDAT- 2026/03/28 06:40 MHDA- 2026/03/28 06:41 PMCR- 2026/03/20 CRDT- 2026/03/28 01:27 PHST- 2026/02/06 00:00 [received] PHST- 2026/03/17 00:00 [revised] PHST- 2026/03/19 00:00 [accepted] PHST- 2026/03/28 06:41 [medline] PHST- 2026/03/28 06:40 [pubmed] PHST- 2026/03/28 01:27 [entrez] PHST- 2026/03/20 00:00 [pmc-release] AID - ijerph23030399 [pii] AID - ijerph-23-00399 [pii] AID - 10.3390/ijerph23030399 [doi] PST - epublish SO - Int J Environ Res Public Health. 2026 Mar 20;23(3):399. doi: 10.3390/ijerph23030399. PMID- 41899237 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260328 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 6 DP - 2026 Mar 18 TI - Identifying Predictors of Lung Volume in Pediatric Patients Undergoing Surgery: A STROBE-Compliant Retrospective Cross-Sectional Chest Computed Tomography Study. LID - 10.3390/jcm15062313 [doi] LID - 2313 AB - Background/Objectives: Tidal volume is determined by height and sex in adults under mechanical ventilation, and it serves as the foundation for implementing a lung-protective ventilation strategy. In children, tidal volume is often calculated based on actual body weight, without established guidelines regarding the predictors of lung volume. The aim of this study was to identify the key predictors of lung volume in children aged 0-5 years. Methods: This retrospective study involved 51 children aged 0-5 years who underwent chest computed tomography (CT) and surgery under general anesthesia between 2014 and 2024. The total lung volume was calculated using three-dimensional segmentation of the CT images. Linear regression models were used to assess predictors, including height, weight, age, sex, and body mass index (BMI). Model performance was evaluated using the adjusted R-squared and Akaike Information Criterion (AIC). Bootstrap validation with 2000 iterations was used to validate model reliability. Results: Height was the strongest predictor of lung volume (adjusted R-squared: 0.5621), and it showed a collinearity with age. The final model included age and sex as the covariates. The Bootstrap validation confirmed the model's reliability. Conclusions: Age and sex are key predictors of the CT-derived total lung volume in children aged 0-5 years. Further studies are required to validate these findings. In addition, research is needed to derive and validate a tidal volume equation based on these predictors and assess the influence of this equation on clinical outcomes such as atelectasis, oxygenation, and inflammatory markers in pediatric surgery. FAU - Lee, Sou-Hyun AU - Lee SH AUID- ORCID: 0000-0002-6785-7688 AD - Department of Anesthesiology and Pain Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 41944, Republic of Korea. FAU - Lim, Dong Gun AU - Lim DG AUID- ORCID: 0000-0002-0976-2576 AD - Department of Anesthesiology and Pain Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 41944, Republic of Korea. FAU - Park, Sung-Sik AU - Park SS AD - Department of Anesthesiology and Pain Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 41944, Republic of Korea. FAU - Jeon, Younghoon AU - Jeon Y AUID- ORCID: 0000-0002-7168-4214 AD - Department of Anesthesiology and Pain Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 41944, Republic of Korea. FAU - Yeo, Jinseok AU - Yeo J AUID- ORCID: 0000-0001-9686-9955 AD - Department of Anesthesiology and Pain Medicine, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine, Daegu 41404, Republic of Korea. FAU - Jung, Hoon AU - Jung H AD - Department of Anesthesiology and Pain Medicine, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine, Daegu 41404, Republic of Korea. FAU - Yeom, Jiyong AU - Yeom J AD - Department of Anesthesiology and Pain Medicine, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine, Daegu 41404, Republic of Korea. FAU - Choi, Chanhyo AU - Choi C AUID- ORCID: 0009-0000-4333-9504 AD - Department of Anesthesiology and Pain Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 41944, Republic of Korea. FAU - Kwak, Kyung-Hwa AU - Kwak KH AD - Department of Anesthesiology and Pain Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 41944, Republic of Korea. LA - eng PT - Journal Article DEP - 20260318 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13027331 OTO - NOTNLM OT - computed tomography OT - linear model OT - pediatrics OT - respiratory physiological phenomena OT - total lung capacity COIS- The authors declare no conflicts of interest. EDAT- 2026/03/28 06:40 MHDA- 2026/03/28 06:41 PMCR- 2026/03/18 CRDT- 2026/03/28 01:25 PHST- 2026/02/05 00:00 [received] PHST- 2026/03/04 00:00 [revised] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/03/28 06:41 [medline] PHST- 2026/03/28 06:40 [pubmed] PHST- 2026/03/28 01:25 [entrez] PHST- 2026/03/18 00:00 [pmc-release] AID - jcm15062313 [pii] AID - jcm-15-02313 [pii] AID - 10.3390/jcm15062313 [doi] PST - epublish SO - J Clin Med. 2026 Mar 18;15(6):2313. doi: 10.3390/jcm15062313. PMID- 41898801 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 2073-4425 (Electronic) IS - 2073-4425 (Linking) VI - 17 IP - 3 DP - 2026 Feb 26 TI - Diagnosis of Familial Hypercholesterolemia in Children: From Clinical Features Through Gene Variants to Polygenic Score. LID - 10.3390/genes17030267 [doi] LID - 267 AB - BACKGROUND: Early diagnosis of familial hypercholesterolemia (FH) is crucial to improve long-term outcomes. FH diagnosis relies on elevated low-density lipoprotein cholesterol (LDL-C) levels, familial clinical characteristics, and identification of pathogenic variants in FH-related genes. Secondary factors, such as overweight and obesity, are known to influence lipid profiles in the general population. More recently, polygenic risk scores based on single-nucleotide polymorphisms (SNPs) have been proposed as additional determinants of LDL-C levels. METHODS: We enrolled 214 pediatric subjects with LDL-C levels >/=95th percentile (after 6 months of dietary intervention) and with at least one parent with LDL-C levels >/= 95th percentile. All participants underwent biochemical and auxological assessment and genetic testing for FH. In a subgroup of 60 subjects, LDL-C polygenic scores based on 6- and 12-SNPs were calculated. RESULTS: Pathogenic variants confirming heterozygous FH were identified in 190 subjects (variant-positive, V+); 17 were variant-negative (V-), yielding a mutation detection rate of 91.8%. An additional seven patients carrying variants of uncertain significance were excluded from the primary analysis. LDL-C was modestly higher in V+ than V- subjects using both Friedewald (212 vs. 188 mg/dL; p = 0.035) and Martin-Hopkins formulas (208 vs. 187 mg/dL; p = 0.041), while the other main clinical and laboratory parameters were similar. In V+, LDL-C was higher in subjects with null variants, compared to those with defective variants. Body mass index (BMI SDS) was inversely correlated with HDL-C (p < 0.001), and obesity (BMI z-score > 2 SDS) was associated with lower HDL-C and higher LDL-C, non-HDL-C, and ApoB. With regard to the polygenic scores, 12- and 6-SNP scores showed overlap between V+ and V-, and published cut-offs did not discriminate lipid severity in our population; however, in V+ subjects, the 12-SNP score acted as a phenotype modifier, being independently associated with higher LDL-C and non-HDL-C levels after adjustment for age, sex, and BMI SDS. CONCLUSIONS: In children selected by LDL-C >/= 95th percentile, together with autosomal dominant familial hypercholesterolemia, genetic confirmation of FH is achieved in the vast majority of cases. Variant type (null vs. defective), BMI, and polygenic background contribute to phenotypic heterogeneity, supporting the need to address other factors alongside genetic diagnosis. Further validation is needed before polygenic scores can be implemented in routine clinical practice. FAU - Buganza, Raffaele AU - Buganza R AUID- ORCID: 0000-0003-1850-2300 AD - Department of Public Health and Pediatric Sciences, University of Turin, Regina Margherita Children's Hospital, 10126 Turin, Italy. FAU - Nobili, Cecilia AU - Nobili C AUID- ORCID: 0009-0001-5112-8982 AD - Department of Public Health and Pediatric Sciences, University of Turin, Regina Margherita Children's Hospital, 10126 Turin, Italy. FAU - Massini, Giulia AU - Massini G AD - Department of Public Health and Pediatric Sciences, University of Turin, Regina Margherita Children's Hospital, 10126 Turin, Italy. FAU - Cardiero, Giovanna AU - Cardiero G AD - Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, 80131 Naples, Italy. AD - CEINGE-Biotecnologie Avanzate Franco Salvatore, 80145 Naples, Italy. FAU - Di Taranto, Maria Donata AU - Di Taranto MD AUID- ORCID: 0000-0002-0618-7940 AD - Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, 80131 Naples, Italy. AD - CEINGE-Biotecnologie Avanzate Franco Salvatore, 80145 Naples, Italy. FAU - de Sanctis, Luisa AU - de Sanctis L AD - Department of Public Health and Pediatric Sciences, University of Turin, Regina Margherita Children's Hospital, 10126 Turin, Italy. FAU - Guardamagna, Ornella AU - Guardamagna O AUID- ORCID: 0000-0003-3137-5916 AD - Department of Public Health and Pediatric Sciences, University of Turin, Regina Margherita Children's Hospital, 10126 Turin, Italy. LA - eng PT - Journal Article DEP - 20260226 PL - Switzerland TA - Genes (Basel) JT - Genes JID - 101551097 RN - 0 (Cholesterol, LDL) SB - IM MH - Humans MH - *Hyperlipoproteinemia Type II/genetics/diagnosis/blood MH - Female MH - Child MH - Male MH - Genetic Risk Score MH - Cholesterol, LDL/blood/genetics MH - *Polymorphism, Single Nucleotide MH - *Multifactorial Inheritance MH - Adolescent PMC - PMC13025718 OTO - NOTNLM OT - BMI OT - children OT - familial hypercholesterolemia OT - gene variants OT - polygenic score COIS- The authors declare no conflicts of interest. EDAT- 2026/03/28 06:39 MHDA- 2026/03/28 06:40 PMCR- 2026/02/26 CRDT- 2026/03/28 01:23 PHST- 2026/01/14 00:00 [received] PHST- 2026/02/06 00:00 [revised] PHST- 2026/02/14 00:00 [accepted] PHST- 2026/03/28 06:40 [medline] PHST- 2026/03/28 06:39 [pubmed] PHST- 2026/03/28 01:23 [entrez] PHST- 2026/02/26 00:00 [pmc-release] AID - genes17030267 [pii] AID - genes-17-00267 [pii] AID - 10.3390/genes17030267 [doi] PST - epublish SO - Genes (Basel). 2026 Feb 26;17(3):267. doi: 10.3390/genes17030267. PMID- 41897217 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260328 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 6 DP - 2026 Mar 18 TI - Mediterranean Diet Adherence, Physical Activity, and Motivation Toward Physical Education in Adolescent Girls: A Cross-Sectional Study. LID - 10.3390/healthcare14060764 [doi] LID - 764 AB - Background: Adolescence represents a critical period for the adoption of lifestyle behaviors that may influence physical health, emotional well-being, and health-related behaviors later in life. However, limited evidence exists regarding the combined association of dietary habits and physical activity with motivation toward physical education, particularly among adolescent girls from different residential environments. Objective: This study aimed to examine the relationship between adherence to the Mediterranean diet, physical activity levels, and motivation toward physical education among adolescent girls from urban and rural settings. Methods: A cross-sectional study was carried out involving girls aged 12 to 14 years (n = 217; N(Urban) = 108 and N(Rural) = 109). Adherence to the Mediterranean diet, physical activity levels, and motivational dimensions toward PE were assessed using validated questionnaires. Differences between groups were analyzed using analysis of variance (ANOVA), and an analysis of covariance (ANCOVA) was performed controlling for physical activity levels. Effect sizes were calculated using partial eta squared (eta(2)p). Results: Significant differences were observed in intrinsic motivation, identified regulation, introjected regulation, and amotivation according to adherence to the Mediterranean diet (p < 0.05), with small to moderate effect sizes (eta(2)p = 0.029-0.040). Post hoc analyses indicated that girls with optimal adherence to the Mediterranean diet exhibited higher intrinsic motivation toward PE compared with those with low adherence. The ANCOVA revealed that higher physical activity levels were significantly associated with greater intrinsic motivation, particularly among girls from urban environments. No significant differences were found between urban and rural environments in overall physical activity levels or dietary adherence. Conclusions: Greater adherence to the Mediterranean diet and higher levels of physical activity are associated with more self-determined motivational profiles toward physical education in adolescent girls. These findings highlight the importance of integrated school-based interventions that promote healthy eating and active lifestyles to enhance motivation and engagement in PE among adolescent girls. FAU - San Martin Gonzalez, Paula AU - San Martin Gonzalez P AUID- ORCID: 0000-0001-6783-1376 AD - Department of Nursing, Faculty of Health Sciences, Pontifical University of Salamanca, 37002 Salamanca, Spain. FAU - Hermida Carballido, Natalia AU - Hermida Carballido N AD - Department of Health Sciences, Faculty of Health Sciences, University of Burgos, 09001 Burgos, Spain. FAU - Maneiro Dios, Ruben AU - Maneiro Dios R AUID- ORCID: 0000-0002-2215-9720 AD - Department of Special Didactics, Faculty of Education and Sports Sciences, University of Vigo, 36005 Pontevedra, Spain. FAU - Arroyo Del Bosque, Ruben AU - Arroyo Del Bosque R AUID- ORCID: 0000-0002-2460-2140 AD - Department of Specific Didactics, Faculty of Education, University of Burgos, 09001 Burgos, Spain. LA - eng PT - Journal Article DEP - 20260318 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13026701 OTO - NOTNLM OT - Mediterranean diet OT - adolescent girls OT - health promotion OT - healthy lifestyle behaviours OT - school health programs OT - self-determination theory COIS- The authors declare no conflicts of interest. EDAT- 2026/03/28 06:39 MHDA- 2026/03/28 06:40 PMCR- 2026/03/18 CRDT- 2026/03/28 01:17 PHST- 2026/02/02 00:00 [received] PHST- 2026/03/12 00:00 [revised] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/03/28 06:40 [medline] PHST- 2026/03/28 06:39 [pubmed] PHST- 2026/03/28 01:17 [entrez] PHST- 2026/03/18 00:00 [pmc-release] AID - healthcare14060764 [pii] AID - healthcare-14-00764 [pii] AID - 10.3390/healthcare14060764 [doi] PST - epublish SO - Healthcare (Basel). 2026 Mar 18;14(6):764. doi: 10.3390/healthcare14060764. PMID- 41897212 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260328 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 6 DP - 2026 Mar 18 TI - Back Muscle Strength Is Associated with Self-Reported Morning-Erection Frequency in Apparently Healthy Japanese Male University Students: A Cross-Sectional Study. LID - 10.3390/healthcare14060759 [doi] LID - 759 AB - Background/Objectives: Morning erections provide an intercourse-independent indicator of nocturnal erectile physiology. We aimed to examine whether body mass index (BMI) and muscle strength are associated with morning-erection frequency in apparently healthy Japanese male university students. Methods: This cross-sectional study analyzed 125 men with complete data (170 assessed; 45 excluded). Handgrip and back muscle strength were measured using dynamometry; BMI was calculated from height and weight. Morning-erection frequency was assessed using a single 6-category item and was dichotomized as low vs. high. Univariable and multivariable logistic regression models were fitted. Exploratory principal component analysis (PCA) and k-means clustering (k = 2, silhouette-supported) were performed. Results: Seventy-four participants (59.2%) were classified as low frequency. Back muscle strength was associated with high frequency (univariable odds ratio [OR] 1.61; 95% confidence interval [CI] 1.07-2.42; and p = 0.021) and remained significant after adjustment for BMI and handgrip strength (OR 1.88; 95% CI 1.02-3.47; and p = 0.045), whereas BMI and handgrip strength were not significant. Clustering identified two clusters (n = 41 and n = 84); Cluster 2 (higher BMI/strength) had a higher proportion of high morning-erection frequency (48% vs. 27%). Conclusions: In apparently healthy young men, greater back muscle strength was independently associated with higher self-reported morning-erection frequency. In this cohort, 59.2% reported infrequent morning erections, suggesting potential relevance even in early adulthood. Given the exploratory clustering, the single-item outcome, and likely residual confounding, these findings are hypothesis-generating and warrant longitudinal validation. FAU - Endo, Yoshiaki AU - Endo Y AUID- ORCID: 0000-0002-5582-343X AD - Department of Physical Therapy, School of Health Science, International University of Health and Welfare, 2600-1 Kitakanemaru, Otawara 324-8501, Tochigi, Japan. FAU - Tanaka, Takazo AU - Tanaka T AUID- ORCID: 0000-0002-0370-0323 AD - Department of Urology, Tsukuba Gakuen Hospital, 2573-1 Kamiyokoba, Tsukuba 305-0854, Ibaraki, Japan. FAU - Kojo, Kosuke AU - Kojo K AUID- ORCID: 0000-0002-6875-0874 AD - Department of Urology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Ibaraki, Japan. AD - Tsukuba Clinical Research & Development Organization (T-CReDO), University of Tsukuba, 2-1-1 Amakubo, Tsukuba 305-8576, Ibaraki, Japan. AD - Center for Human Reproduction, International University of Health and Welfare Hospital, 537-3 Iguchi, Nasushiobara 329-2763, Tochigi, Japan. FAU - Matsumoto, Chiaki AU - Matsumoto C AUID- ORCID: 0009-0007-1332-3633 AD - Department of Physical Therapy, School of Health Science, International University of Health and Welfare, 2600-1 Kitakanemaru, Otawara 324-8501, Tochigi, Japan. FAU - Kurobe, Masahiro AU - Kurobe M AUID- ORCID: 0000-0002-5819-523X AD - Center for Human Reproduction, International University of Health and Welfare Hospital, 537-3 Iguchi, Nasushiobara 329-2763, Tochigi, Japan. AD - Department of Systems Physiology, Graduate School of Medicine, University of the Ryukyus, 1076 Kiyuna, Ginowan 901-2720, Okinawa, Japan. FAU - Nishiyama, Hiroyuki AU - Nishiyama H AUID- ORCID: 0000-0001-7423-596X AD - Department of Urology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Ibaraki, Japan. FAU - Takayama, Tatsuya AU - Takayama T AUID- ORCID: 0000-0003-3360-7688 AD - Center for Human Reproduction, International University of Health and Welfare Hospital, 537-3 Iguchi, Nasushiobara 329-2763, Tochigi, Japan. AD - Department of Urology, School of Medicine, International University of Health and Welfare, 4-3 Kozunomori, Narita 286-8686, Chiba, Japan. FAU - Miyazaki, Jun AU - Miyazaki J AUID- ORCID: 0000-0002-3618-0432 AD - Department of Urology, School of Medicine, International University of Health and Welfare, 4-3 Kozunomori, Narita 286-8686, Chiba, Japan. LA - eng GR - JPMJPF2017/Japan Science and Technology Agency/ PT - Journal Article DEP - 20260318 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13027116 OTO - NOTNLM OT - adolescent and young adult OT - body composition OT - erectile dysfunction OT - health behavior OT - lifestyle factors OT - muscle strength OT - nocturnal penile tumescence OT - reproductive health OT - sexual function OT - trunk muscles COIS- The authors declare no conflicts of interest. EDAT- 2026/03/28 06:39 MHDA- 2026/03/28 06:40 PMCR- 2026/03/18 CRDT- 2026/03/28 01:17 PHST- 2026/01/28 00:00 [received] PHST- 2026/03/13 00:00 [revised] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/03/28 06:40 [medline] PHST- 2026/03/28 06:39 [pubmed] PHST- 2026/03/28 01:17 [entrez] PHST- 2026/03/18 00:00 [pmc-release] AID - healthcare14060759 [pii] AID - healthcare-14-00759 [pii] AID - 10.3390/healthcare14060759 [doi] PST - epublish SO - Healthcare (Basel). 2026 Mar 18;14(6):759. doi: 10.3390/healthcare14060759. PMID- 41897117 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260328 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 3 DP - 2026 Mar 14 TI - Measuring Digital Stress in Children: Construct Validity, Model Comparisons, and Measurement Invariance of a Multidimensional Scale (DSS-CH). LID - 10.3390/children13030405 [doi] LID - 405 AB - Background: The use of digital media in childhood offers both opportunities and risks. Digital stressors-such as excessive screen time, constant availability, information overload, and social media pressures-affect primary school children but have been rarely studied systematically. Despite growing research, no validated instruments adequately capture how younger children perceive and express digital stress. This study presents the development and validation of a three-dimensional instrument for children under 14: the "Digital Stress in Children" scale (DSS-CH). The DSS-CH is theory-driven and child-appropriate, with three interrelated but distinct dimensions: (1) excessive screen time, (2) compulsive media behavior, and (3) approval anxiety. Methods: In a cross-sectional survey of n = 907 Swiss primary school children (grades 5-6; ages 10-14), participants completed an online questionnaire in class. Latent variable modeling with cluster-robust inference accounted for classroom nesting. Competing models (1-, 2-, 3-factor CFA; ESEM; bifactor-ESEM) were evaluated. Results: The 1-factor CFA fit poorly (CFI approximately 0.81; RMSEA approximately 0.15), while the 3-factor CFA showed acceptable fit (CFI approximately 0.96; RMSEA approximately 0.07). Allowing cross-loadings improved fit substantially in the 3-factor ESEM and bifactor-ESEM (CFI approximately 0.999; RMSEA approximately 0.01), supporting a general digital stress factor alongside facet-specific variance. Subscales showed good reliability (ordinal alpha approximately 0.81 - 0.89) and moderate intercorrelations (r approximately 0.28 - 0.47). Scalar invariance across gender and age was supported (DeltaCFI /= 0.50 for 12 of 14 nutrients, and misclassification into opposite tertiles (> 10% of participants) was observed only for SFAs (13%). Bland-Altman analysis confirmed acceptable agreement for energy and macronutrient intakes. At the food group level, the eFFQ yielded significantly higher median intakes for 14 of 28 food groups - most notably plant-based protein-rich foods and cream, fatty sauces & other fats - and lower median intakes for four groups, including vegetables and fish. Ranking agreement was acceptable for most food groups (SCCs = 0.57-0.91) but weaker for water (0.07); vegetable oil (0.42); cream, fatty sauces & other fats (0.33); and mixed dishes & soups (0.47). CONCLUSIONS: The new eFFQ demonstrated good relative agreement with the previous paper-based FFQ, particularly for ranking individuals. These findings provide valuable information for researchers and policy makers comparing results of both FFQs over time and across populations. FAU - Chatelan, Angeline AU - Chatelan A AD - Department of Nutrition and Dietetics, Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland, Rue des Caroubiers 25, Carouge-Geneva, 1227, Switzerland. angeline.chatelan@hesge.ch. FAU - Chevillard, Elsa AU - Chevillard E AD - Department of Nutrition and Dietetics, Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland, Rue des Caroubiers 25, Carouge-Geneva, 1227, Switzerland. FAU - Pannen, Sarah T AU - Pannen ST AD - Division of Chronic Disease Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland. AD - Swiss School of Public Health, Zurich, Switzerland. FAU - Hillesheim, Elaine AU - Hillesheim E AD - Department of Nutrition and Dietetics, Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland, Rue des Caroubiers 25, Carouge-Geneva, 1227, Switzerland. FAU - Stringhini, Silvia AU - Stringhini S AD - Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. AD - Faculty of Medicine, University of Geneva, Geneva, Switzerland. AD - School of Population and Public Health and Edwin S.H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, Canada. FAU - Nehme, Mayssam AU - Nehme M AD - Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. AD - Faculty of Medicine, University of Geneva, Geneva, Switzerland. FAU - Guessous, Idris AU - Guessous I AD - Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. AD - Faculty of Medicine, University of Geneva, Geneva, Switzerland. FAU - Rohrmann, Sabine AU - Rohrmann S AD - Division of Chronic Disease Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland. AD - Swiss School of Public Health, Zurich, Switzerland. FAU - Steinemann, Nina AU - Steinemann N AD - Division of Chronic Disease Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland. FAU - Sych, Janice AU - Sych J AD - Institute of Food and Beverage Innovation, ZHAW School of Life Sciences and Facility Management, Wadenswil, Switzerland. FAU - Marques-Vidal, Pedro AU - Marques-Vidal P AD - Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. LA - eng GR - 13-M22/Research and Impulse Funds (FRI)/ PT - Journal Article DEP - 20260327 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 RN - 0 (Micronutrients) RN - 0 (Dietary Fats) SB - IM MH - Humans MH - Switzerland MH - Female MH - Middle Aged MH - Adult MH - Male MH - Aged MH - *Internet MH - Adolescent MH - Young Adult MH - *Diet Surveys/methods MH - Surveys and Questionnaires MH - Energy Intake MH - *Diet MH - Nutrition Assessment MH - Reproducibility of Results MH - Micronutrients/administration & dosage MH - Diet Records MH - Dietary Fats/administration & dosage PMC - PMC13147631 OTO - NOTNLM OT - Diet OT - Dietary assessment OT - Digital health OT - Epidemiology OT - Food frequency questionnaire OT - Internet OT - Validation study COIS- Declarations. Ethics approval and consent to participate: This study was conducted according to the guidelines laid down in the Declaration of Helsinki. The study was reviewed by the Ethics Committee of the Canton of Zurich, which determined that formal ethical approval was not required (Req-2022-01268, same request as for the validation study of the eFFQ by Pannen et al.). All participants signed an electronic informed consent detailing the study protocol, objectives and data management procedures. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/28 06:39 MHDA- 2026/06/27 18:38 PMCR- 2026/03/27 CRDT- 2026/03/28 01:07 PHST- 2025/11/05 00:00 [received] PHST- 2026/03/08 00:00 [accepted] PHST- 2026/06/27 18:38 [medline] PHST- 2026/03/28 06:39 [pubmed] PHST- 2026/03/28 01:07 [entrez] PHST- 2026/03/27 00:00 [pmc-release] AID - 10.1186/s12937-026-01309-7 [pii] AID - 1309 [pii] AID - 10.1186/s12937-026-01309-7 [doi] PST - epublish SO - Nutr J. 2026 Mar 27;25(1):59. doi: 10.1186/s12937-026-01309-7. PMID- 41895835 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 1440-6047 (Electronic) IS - 0964-7058 (Print) IS - 0964-7058 (Linking) VI - 35 IP - 2 DP - 2026 Apr TI - Diet quality of Japanese preschool children assessed by the Healthy Eating Index-2020: Nutrient and food group intake, as well as weekday-weekend differences. PG - 281-327 LID - 10.6133/apjcn.202604_35(2).0010 [doi] AB - BACKGROUND AND OBJECTIVES: In Japan, there are no official dietary guidelines for young children and nutrients may be insufficient on weekends, compared to weekdays at nursery schools. To ensure adequate nutrition, an appropriate dietary evaluation method is required. This study used the Healthy Eating Index (HEI)-2020, which is based on the Dietary Guidelines for Americans, to evaluate the diet quality of Japanese children, examine its validity through associations with nutrient and food group intake, and compare dietary characteristics on weekdays and weekends. METHODS AND STUDY DESIGN: The participants were 669 children aged 3 to 5 years attending nursery schools across Japan. Relationships of HEI-2020 scores with nutrient and food group intake, and comparisons between weekdays and weekends were evaluated. RESULTS: The median HEI-2020 score was 50/100, with almost maximum scores for Total Protein Foods, Seafood and Plant Pro-teins, and Added Sugars, while Whole Grains and Refined Grains scored zero. Additionally, the largest score differences between weekdays and weekends were found in Dairy and Greens and Beans. Higher HEI-2020 scores correlated with lower saturated fatty acids intake and higher intakes of dietary fiber, vitamins, and minerals. Weekday scores were significantly higher and less varied than weekend scores. CONCLUSIONS: HEI-2020 can identify nutrient intake challenges in Japanese children. Greater consumption of Dairy and Greens and Beans-components that showed large weekday-weekend differences-may improve diet quality. FAU - Akazawa, Hazuki AU - Akazawa H AD - Graduate School of Human Life and Ecology, Osaka Metropolitan University, Osaka, Osaka, Japan. Email: hazuki.akazawa@nissin.com. AD - NISSIN Global Food Safety Institute, NISSIN FOODS HOLDINGS CO., LTD, Hachioji, Tokyo, Japan. AD - National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health, and Nutrition, Settsu, Osaka, Japan. FAU - Sakai, Atsuki AU - Sakai A AD - Graduate School of Human Life and Ecology, Osaka Metropolitan University, Osaka, Osaka, Japan. FAU - Takahashi, Takako AU - Takahashi T AD - Graduate School of Human Life and Ecology, Osaka Metropolitan University, Osaka, Osaka, Japan. FAU - Okabe, Tetsuko AU - Okabe T AD - School of Nursing and Nutrition, Tenshi College, Sapporo, Hokkaido, Japan. FAU - Sasaki, Ruriko AU - Sasaki R AD - Faculty of Human Life Science, Miyagi Gakuin Women's University, Sendai, Miyagi, Japan. FAU - Ishida, Hiromi AU - Ishida H AD - Faculty of Nutrition, Kagawa Nutrition University, Sakado, Saitama, Japan. FAU - Ogata, Hiromitsu AU - Ogata H AD - Faculty of Nutrition, Kagawa Nutrition University, Sakado, Saitama, Japan. FAU - Hara, Mitsuhiko AU - Hara M AD - Faculty of Human Ecology, Wayo Women's University, Ichikawa, Chiba, Japan. FAU - Yoshioka, Yukiko AU - Yoshioka Y AD - Faculty of Nutritional Science, Sagami Women's University, Sagamihara, Kanagawa, Japan. FAU - Nozue, Miho AU - Nozue M AD - Faculty of Health Promotional Sciences, Tokoha University, Hamamatsu, Shizuoka, Japan. FAU - Sakamoto, Tatsuaki AU - Sakamoto T AD - Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Kumamoto, Kumamo-to, Japan. FAU - Ito, Sanae AU - Ito S AD - Faculty of Medicine, University of the Ryukyus, Ginowan, Okinawa, Japan. FAU - Murayama, Nobuko AU - Murayama N AD - Faculty of Human Life Studies, University of Niigata Prefecture, Niigata, Niigata, Japan. FAU - Yoshita, Katsushi AU - Yoshita K AD - Graduate School of Human Life and Ecology, Osaka Metropolitan University, Osaka, Osaka, Japan. LA - eng PT - Journal Article PL - China TA - Asia Pac J Clin Nutr JT - Asia Pacific journal of clinical nutrition JID - 9440304 RN - Japanese people SB - IM MH - Humans MH - Japan MH - Child, Preschool MH - *Diet, Healthy/statistics & numerical data MH - Female MH - Male MH - *Nutrients MH - *Diet/statistics & numerical data MH - Nutrition Policy MH - Nutrition Assessment MH - Nutritive Value MH - *Diet Surveys MH - Child Nutritional Physiological Phenomena MH - East Asian People PMC - PMC13012830 OTO - NOTNLM OT - child nutrition OT - diet quality OT - dietary evaluation OT - nutrient profiling system OT - weekdays vs weekends COIS- HA declares that she is employed by NISSIN FOODS HOLDINGS CO., LTD. and has no competing interests. The other authors declare that they have no competing interests EDAT- 2026/03/28 00:42 MHDA- 2026/03/28 00:43 PMCR- 2026/03/17 CRDT- 2026/03/27 21:32 PHST- 2026/03/28 00:43 [medline] PHST- 2026/03/28 00:42 [pubmed] PHST- 2026/03/27 21:32 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - 10.6133/apjcn.202604_35(2).0010 [doi] PST - ppublish SO - Asia Pac J Clin Nutr. 2026 Apr;35(2):281-327. doi: 10.6133/apjcn.202604_35(2).0010. PMID- 41895828 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 1440-6047 (Electronic) IS - 0964-7058 (Print) IS - 0964-7058 (Linking) VI - 35 IP - 2 DP - 2026 Apr TI - Association between the frequency of combined staple, main, and side dishes and nutritional adequacy among young Japanese women: A cross-sectional study. PG - 197-206 LID - 10.6133/apjcn.202604_35(2).0003 [doi] AB - BACKGROUND AND OBJECTIVES: Traditional Japanese diet comprises staple food, main dish, and side dish (SMS). Studies reporting the association between the frequency of SMS meals consumption and nutritional adequacy remain limited. We aimed to examine the association between the frequency of SMS meals consumption and nutritional adequacy in young Japanese women. METHODS AND STUDY DESIGN: In this cross-sectional study, data from 329 female nutrition students aged 18-25 years were analysed. The frequency of SMS meals consumption more than twice a day was assessed using a self-administered questionnaire, and dietary intake was evaluated using a validated food frequency questionnaire. We examined the association between SMS meals consumption and likelihood of not meeting the Dietary Goal (DG) or the Estimated Average Requirement (EAR) as defined in the Japanese Dietary Reference Intakes for Japanese. Trend analyses were performed to evaluate the relationship between SMS meal frequency and the number of nutrients not meeting the DG or EAR, while adjusting for potential confounders. RESULTS: Participants with high frequency of SMS meals consumption (5-7 days/week) had the lowest number of nutrients not meeting the EAR and DG, with significant linear trends observed across categories (p for trend <0.001 for DG; 0.001 for EAR). CONCLUSIONS: Frequency of SMS meals consumption is positively associated with improved nutrient intake among young Japanese women. However, given that the participants were dietetic students with relatively high nutrition literacy, caution is needed when generalising these findings to the wider population of young Japanese women. FAU - Yaegashi, Akinori AU - Yaegashi A AD - Department of Nutrition, Faculty of Health and Welfare, Takasaki University of Health and Welfare, Gunma, Japan. Email: yaegashi-a@takasaki-u.ac.jp. AD - Graduate School of Medicine, Hokkaido University, Hokkaido, Japan. FAU - Ota, Ai AU - Ota A AD - Freelance Researcher, Saitama, Japan. FAU - Shirahata, Aki AU - Shirahata A AD - Department of Health and Nutrition, Faculty of Human Science, Hokkaido Bunkyo University, Eniwa, Japan. FAU - Takada, Hiyori AU - Takada H AD - Department of Nutrition, School of Health Sciences, Sapporo University of Health Sciences, Hokkaido, Japan. FAU - Nakamura, Miki AU - Nakamura M AD - Department of Health and Nutrition, Faculty of Human Science, Hokkaido Bunkyo University, Eniwa, Japan. AD - Department of Nutrition, School of Health Sciences, Sapporo University of Health Sciences, Hokkaido, Japan. FAU - Katou, Hizuru AU - Katou H AD - Department of Health and Nutrition, Faculty of Human Science, Hokkaido Bunkyo University, Eniwa, Japan. FAU - Kozuka, Miyuki AU - Kozuka M AD - Department of Health and Nutrition, Faculty of Human Science, Hokkaido Bunkyo University, Eniwa, Japan. LA - eng PT - Journal Article PL - China TA - Asia Pac J Clin Nutr JT - Asia Pacific journal of clinical nutrition JID - 9440304 RN - Japanese people SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Japan MH - Young Adult MH - Adolescent MH - Adult MH - *Diet MH - *Nutritional Status MH - *Meals MH - *Feeding Behavior MH - Nutritional Requirements MH - Surveys and Questionnaires MH - East Asian People PMC - PMC13012828 OTO - NOTNLM OT - nutritional epidemiology OT - young woman OT - Japanese OT - nutritional adequacy OT - staple food COIS- No conflicts of interest are to be declared EDAT- 2026/03/28 00:42 MHDA- 2026/03/28 00:43 PMCR- 2026/03/17 CRDT- 2026/03/27 21:32 PHST- 2026/03/28 00:43 [medline] PHST- 2026/03/28 00:42 [pubmed] PHST- 2026/03/27 21:32 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - 10.6133/apjcn.202604_35(2).0003 [doi] PST - ppublish SO - Asia Pac J Clin Nutr. 2026 Apr;35(2):197-206. doi: 10.6133/apjcn.202604_35(2).0003. PMID- 41895696 OWN - NLM STAT- MEDLINE DCOM- 20260615 LR - 20260813 IS - 2156-5376 (Electronic) IS - 2161-8313 (Print) IS - 2161-8313 (Linking) VI - 17 IP - 6 DP - 2026 Jun TI - Healthy Diet Metrics for Children and Adolescents and Their Suitability for Global Monitoring: A Critical Review. PG - 100622 LID - S2161-8313(26)00036-0 [pii] LID - 10.1016/j.advnut.2026.100622 [doi] LID - 100622 AB - Healthy diets during childhood and adolescence are paramount for growth, development, and long-term health. However, there is a lack of low-burden standardized metrics to assess and monitor healthy diets among children and adolescents aged 2-19 y on a global scale. This critical review aimed to identify and evaluate existing metrics for assessing healthy diets in this age group and to determine their suitability for global monitoring based on feasibility and adaptability across different contexts. A systematic search was conducted across 3 global databases, encompassing both peer-reviewed and grey literature. A total of 127 distinct healthy diet metrics were identified, many of which were developed or adapted based on national dietary guidelines across various geographical contexts. Only 5 were deemed suitable for global monitoring due to their feasibility and adaptability: the Individual Dietary Diversity Score, 7 food group Minimum Dietary Diversity, 10 food group Minimum Dietary Diversity, Healthy Plate Variety Score, and Adapted ultraprocessed food Nova Score. Among these metrics, diversity was the most commonly measured subconstruct of a healthy diet, whereas only the Adapted Nova Score aimed to capture moderation. These 5 metrics were further evaluated for construct validity, reliability, and cross-context equivalence, which revealed large evidence gaps, particularly regarding sensitivity to change and test-retest reliability. These findings highlight the need for additional research to validate healthy diet metrics globally to ensure their accuracy, sensitivity, and reliability to differentiate populations and changes over time. Developing robust, low-burden metrics is essential for informing effective, timely nutrition policies and interventions aimed at improving the diets of children and adolescents worldwide. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Pries, Alissa M AU - Pries AM AD - Independent consultant, London, United Kingdom. Electronic address: hello@alissapries.com. FAU - Craig, Hope AU - Craig H AD - Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, United States. FAU - Mehra, Vrinda AU - Mehra V AD - Data & Analytics Section, Division of Data, Analytics, Planning and Monitoring, United Nations Children's Fund, New York, NY, United States. FAU - Frongillo, Edward A AU - Frongillo EA AD - Department of Health Promotion, Education, and Behavior, University of South Carolina, Columbia, SC, United States. FAU - Hanley-Cook, Giles T AU - Hanley-Cook GT AD - Food and Nutrition Division, Food and Agriculture Organization of the United Nations, Rome, Italy. FAU - Hayashi, Chika AU - Hayashi C AD - Data & Analytics Section, Division of Data, Analytics, Planning and Monitoring, United Nations Children's Fund, New York, NY, United States. FAU - Saha, Kuntal AU - Saha K AD - Department of Nutrition and Food Safety, World Health Organisation, Geneva, Switzerland. FAU - Sattamini, Isabela Fleury AU - Sattamini IF AD - Department of Nutrition and Food Safety, World Health Organisation, Geneva, Switzerland. FAU - Schwendler, Teresa R AU - Schwendler TR AD - Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, United States. FAU - Coates, Jennifer C AU - Coates JC AD - Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, United States. CN - Healthy Diets Monitoring Initiative LA - eng PT - Journal Article PT - Review DEP - 20260325 PL - United States TA - Adv Nutr JT - Advances in nutrition (Bethesda, Md.) JID - 101540874 SB - IM MH - Humans MH - Child MH - Adolescent MH - *Diet, Healthy/standards MH - Child, Preschool MH - *Nutrition Policy MH - Reproducibility of Results MH - Evidence Gaps MH - Global Health PMC - PMC13223966 OTO - NOTNLM OT - adolescents OT - children OT - diets OT - global monitoring OT - metrics COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/03/28 00:42 MHDA- 2026/06/16 00:33 PMCR- 2026/03/25 CRDT- 2026/03/27 20:19 PHST- 2025/04/23 00:00 [received] PHST- 2026/02/02 00:00 [revised] PHST- 2026/03/19 00:00 [accepted] PHST- 2026/06/16 00:33 [medline] PHST- 2026/03/28 00:42 [pubmed] PHST- 2026/03/27 20:19 [entrez] PHST- 2026/03/25 00:00 [pmc-release] AID - S2161-8313(26)00036-0 [pii] AID - 100622 [pii] AID - 10.1016/j.advnut.2026.100622 [doi] PST - ppublish SO - Adv Nutr. 2026 Jun;17(6):100622. doi: 10.1016/j.advnut.2026.100622. Epub 2026 Mar 25. PMID- 41894591 OWN - NLM STAT- MEDLINE DCOM- 20260610 LR - 20260909 IS - 1097-4679 (Electronic) IS - 0021-9762 (Print) IS - 0021-9762 (Linking) VI - 82 IP - 7 DP - 2026 Jul TI - Relative Contributions of Gastrointestinal-Specific Hypervigilance and Anxiety in Explaining Eating Disorder Symptoms. PG - 1078-1085 LID - 10.1002/jclp.70134 [doi] AB - OBJECTIVE: Gastrointestinal (GI) disturbances and eating disorder symptoms commonly co-occur. Hypervigilance and anxiety about GI symptoms may motivate eating disorder behaviors to manage and/or avoid GI symptoms. We hypothesized that GI-specific anxiety would be more strongly associated with dietary restriction and purging than GI-specific hypervigilance. Further, we hypothesized that distinguishing between GI-specific anxiety and hypervigilance would have incremental validity over using an existing measure of GI-anxiety and related constructs initially developed for patients with irritable bowel syndrome, the Visceral Sensitivity Index. METHODS: Three hundred and eighty-two undergraduate students with elevated eating pathology (83.5% female, 87.4% White) completed questionnaires assessing GI-specific hypervigilance and anxiety, the Visceral Sensitivity Index, and eating disorder symptoms. Participants were recruited with elevated shape/weight-oriented eating pathology (N = 309) and elevated avoidant/restrictive food intake disorder-related eating pathology (N = 73). Analyses were pre-registered. RESULTS: Regarding dietary restriction, the relative weight of GI-specific anxiety did not differ from that of GI-specific hypervigilance. Further, neither variable provided incremental validity over the Visceral Sensitivity Index in understanding restriction. Regarding purging, GI-specific anxiety was not more strongly associated with purging than GI-specific hypervigilance. However, GI-specific anxiety, but not GI-specific hypervigilance, demonstrated incremental validity over the Visceral Sensitivity Index in explaining purging. CONCLUSION: Distinguishing between GI-specific hypervigilance and anxiety adds incremental validity in understanding purging but not restriction. Future research should examine whether addressing anxious cognitions about GI symptoms improves purging outcomes. CI - (c) 2026 The Author(s). Journal of Clinical Psychology published by Wiley Periodicals LLC. FAU - Pucci, Gabriella AU - Pucci G AD - Department of Psychology, Ohio University, Athens, Ohio, USA. FAU - Hill, Naomi G AU - Hill NG AUID- ORCID: 0000-0002-6955-1746 AD - Department of Psychology, Ohio University, Athens, Ohio, USA. FAU - Schneider, Zoe AU - Schneider Z AD - Department of Psychology, Ohio University, Athens, Ohio, USA. AD - Carnegie Mellon University, Pittsburgh, Pennsylvania, USA. FAU - Brown, Tiffany A AU - Brown TA AUID- ORCID: 0000-0002-7349-7228 AD - Department of Psychological Sciences, Auburn University, Auburn, Alabama, USA. FAU - Burton-Murray, Helen AU - Burton-Murray H AUID- ORCID: 0000-0003-2059-3256 AD - Division of Gastroenterology, Center for Neurointestinal Health, Massachusetts General Hospital, Boston, Massachusetts, USA. AD - Harvard Medical School, Boston, Massachusetts, USA. FAU - Guadagnoli, Livia AU - Guadagnoli L AUID- ORCID: 0000-0002-2925-3955 AD - Department of Gastroenterology and Hepatology, Northwestern Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Forney, K Jean AU - Forney KJ AD - Department of Psychology, Ohio University, Athens, Ohio, USA. LA - eng GR - K23 DK131334/DK/NIDDK NIH HHS/United States GR - K23 DK131334/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, P.H.S. DEP - 20260327 PL - United States TA - J Clin Psychol JT - Journal of clinical psychology JID - 0217132 SB - IM MH - Humans MH - Female MH - *Anxiety/physiopathology MH - *Feeding and Eating Disorders/physiopathology/psychology MH - Male MH - *Gastrointestinal Diseases/physiopathology/psychology MH - Young Adult MH - Adult MH - Adolescent PMC - PMC13104586 MID - NIHMS2165072 OTO - NOTNLM OT - anxiety OT - feeding and eating disorders OT - gastrointestinal symptoms OT - hypervigilance OT - purging OT - restriction COIS- H.B.-M. receives royalties from Oxford University Press for her book Cognitive Behavioral Therapy for Rumination Syndrome and from Cambridge University Press for her forthcoming book on functional bowel disorders. The other authors declare no conflicts of interest. EDAT- 2026/03/27 18:52 MHDA- 2026/06/10 06:52 PMCR- 2026/06/06 CRDT- 2026/03/27 14:53 PHST- 2026/02/19 00:00 [revised] PHST- 2025/08/29 00:00 [received] PHST- 2026/03/17 00:00 [accepted] PHST- 2026/06/10 06:52 [medline] PHST- 2026/03/27 18:52 [pubmed] PHST- 2026/03/27 14:53 [entrez] PHST- 2026/06/06 00:00 [pmc-release] AID - JCLP70134 [pii] AID - 10.1002/jclp.70134 [doi] PST - ppublish SO - J Clin Psychol. 2026 Jul;82(7):1078-1085. doi: 10.1002/jclp.70134. Epub 2026 Mar 27. PMID- 41894565 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260327 LR - 20260925 IS - 1929-073X (Print) IS - 1929-073X (Electronic) IS - 1929-073X (Linking) VI - 15 DP - 2026 Mar 27 TI - The Lifetime Dance Exposure Questionnaire for Professional Training: Survey Development and Reliability Study. PG - e75632 LID - 10.2196/75632 [doi] LID - e75632 AB - BACKGROUND: Dance is a complex mode of physical activity (PA) behavior and an art form, and one's participation in dance may occur across discrete contexts throughout the lifespan. To further advance the study of lifetime participation in dance behavior, reliable questionnaires are needed. OBJECTIVE: This study aimed to develop and test the reliability of a self-report, online questionnaire for surveilling lifetime participation in professionally led dance classes among adults. METHODS: Community-dwelling adults (N=373) completed the Lifetime Dance Exposure Questionnaire for Professional Training (LDEQ-T) at baseline (T1), and 150 adults repeated the LDEQ-T after an 8-week delay (T2). Test-retest reliability for self-reported dance training frequency, duration, and PA intensity was analyzed for the LDEQ-T between T1 and T2. Reliability for the LDEQ-T item on total years of professional dance training was assessed using intraclass correlation coefficients (ICCs; 2-way, random effects); linearly weighted kappa (𝜿w) was used for ordinal variables on dance class duration, intensity, and frequency; an unweighted kappa (𝜿) statistic was used to test the reliability of 3 dance training exposure groups (no or low, homogenous, or variable lifetime exposure to professional dance training). The significance level was set a priori with alpha=.05. RESULTS: Adults reported having no or low (n=92), homogenous (n=196), or variable (n=85) lifetime exposures to professional dance classes at T1. Among adults who self-reported homogenous exposures to dance training throughout the lifespan, years of dance training were found to be reliable across all age periods (ICC range 0.83-0.94); as were weeks/month, months/year, and hours/week of dance training (𝜿w range 0.35-0.61); but not any measure of PA intensity. Among adults who self-reported variable exposures to dance training, years of dance training across all age periods (ICC=0.70-0.96); classes/week, weeks/month, months/year, and hours/week (𝜿w range 0.32-0.56); and some estimates of PA intensity (𝜿w range 0.30-0.41) were found to be sufficiently reliable. CONCLUSIONS: The LDEQ-T appears to be a reliable instrument for quantifying lifetime participation in professional dance training among adults with self-reported low, homogenous, or variable exposures to professional dance classes throughout the lifespan. Among adults, researchers may surveil lifetime exposure to dance training in early childhood, childhood, adolescence, young adulthood, and middle or older adulthood using the LDEQ-T. CI - (c) Aston K McCullough, Kai Yi (Kaye) Han. Originally published in the Interactive Journal of Medical Research (https://www.i-jmr.org/). FAU - McCullough, Aston K AU - McCullough AK AUID- ORCID: 0000-0003-2021-5554 AD - Laboratory for the Scientific Study of Dance, Institute for Cognitive and Brain Health, Northeastern University, 360 Huntington Ave, 129 ISEC, Boston, MA, 02115, United States, 1 6173738893. AD - Department of Physical Therapy, Movement and Rehabilitation Sciences, Northeastern University, Boston, MA, United States. AD - Department of Music, Northeastern University, Boston, MA, United States. FAU - Han, Kai Yi Kaye AU - Han KYK AUID- ORCID: 0009-0004-9277-5811 AD - Laboratory for the Scientific Study of Dance, Institute for Cognitive and Brain Health, Northeastern University, 360 Huntington Ave, 129 ISEC, Boston, MA, 02115, United States, 1 6173738893. LA - eng PT - Journal Article DEP - 20260327 PL - Canada TA - Interact J Med Res JT - Interactive journal of medical research JID - 101598421 PMC - PMC13026436 OTO - NOTNLM OT - adult OT - physical activity OT - self-report OT - survey OT - test-retest reliability COIS- Conflicts of Interest: None declared. EDAT- 2026/03/27 18:51 MHDA- 2026/03/27 18:52 PMCR- 2026/03/27 CRDT- 2026/03/27 14:22 PHST- 2025/04/07 00:00 [received] PHST- 2025/12/11 00:00 [revised] PHST- 2025/12/17 00:00 [accepted] PHST- 2026/03/27 18:52 [medline] PHST- 2026/03/27 18:51 [pubmed] PHST- 2026/03/27 14:22 [entrez] PHST- 2026/03/27 00:00 [pmc-release] AID - v15i1e75632 [pii] AID - 75632 [pii] AID - 10.2196/75632 [doi] PST - epublish SO - Interact J Med Res. 2026 Mar 27;15:e75632. doi: 10.2196/75632. PMID- 41892828 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 2076-3271 (Electronic) IS - 2076-3271 (Linking) VI - 14 IP - 1 DP - 2026 Feb 26 TI - Purpose in Life and Estimated Type 2 Diabetes Risk: Cross-Sectional Associations Across Three Validated Risk Scores in 93,077 Spanish Working Adults. LID - 10.3390/medsci14010113 [doi] LID - 113 AB - Background: Psychosocial well-being has been increasingly recognized as a relevant factor in cardiometabolic health; however, evidence linking Purpose in Life with type 2 diabetes risk across validated prediction tools remains limited. This study examined the association between Purpose in Life and estimated diabetes risk using three established risk scores. Methods: A cross-sectional analysis was performed in 93,077 Spanish working adults aged 18-69 years participating in routine occupational health assessments. Purpose in Life was measured with the 10-item Purpose in Life scale and categorized into high, moderate, and low levels. Estimated type 2 diabetes risk was evaluated using QDScore, FINDRISC, and CANRISK. Multivariable logistic regression models were applied to calculate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for age, sex, occupational social class, smoking status, dietary pattern, physical activity, and body mass index. Results: Lower levels of Purpose in Life were consistently associated with greater likelihood of high estimated diabetes risk across all three instruments. Compared with participants reporting high Purpose in Life, those with low Purpose in Life showed increased odds of high-risk classification for QDScore (OR 2.38; 95% CI 2.19-2.57), FINDRISC (OR 2.49; 95% CI 2.08-2.89), and CANRISK (OR 2.79; 95% CI 2.50-3.09). Clear dose-response patterns were observed across Purpose in Life categories, and associations were similar in men and women as well as across lifestyle strata. Conclusions: Reduced Purpose in Life is strongly associated with higher estimated type 2 diabetes risk across multiple validated screening tools. Although causal direction cannot be inferred from this cross-sectional design, these findings suggest that psychosocial dimensions may provide complementary information for cardiometabolic risk assessment and prevention strategies. FAU - Garcia Pertegaz, Pilar AU - Garcia Pertegaz P AUID- ORCID: 0009-0006-9309-0480 AD - Quiron Salud Palma Planas Hospital, 07014 Palma, Spain. FAU - Tarraga Lopez, Pedro Juan AU - Tarraga Lopez PJ AUID- ORCID: 0000-0002-5222-5784 AD - Faculty of Medicine, University of Castilla La Mancha (UCLM), 02008 Albacete, Spain. FAU - Coll Campayo, Irene AU - Coll Campayo I AUID- ORCID: 0000-0002-5423-9290 AD - ADEMA-University School, University of the Balearic Islands,07009 Palma, Spain. FAU - Busquets-Cortes, Carla AU - Busquets-Cortes C AUID- ORCID: 0000-0001-9367-2137 AD - ADEMA-University School, University of the Balearic Islands,07009 Palma, Spain. FAU - Lopez-Gonzalez, Angel Arturo AU - Lopez-Gonzalez AA AUID- ORCID: 0000-0002-7439-8117 AD - ADEMA-University School, University of the Balearic Islands,07009 Palma, Spain. FAU - Ramirez-Manent, Jose Ignacio AU - Ramirez-Manent JI AUID- ORCID: 0000-0001-6887-4562 AD - ADEMA-University School, University of the Balearic Islands,07009 Palma, Spain. AD - Faculty of Medicine, University of the Balearic Islands, 07120 Palma, Spain. LA - eng PT - Journal Article DEP - 20260226 PL - Switzerland TA - Med Sci (Basel) JT - Medical sciences (Basel, Switzerland) JID - 101629322 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/epidemiology/psychology MH - Female MH - Middle Aged MH - Male MH - Adult MH - Cross-Sectional Studies MH - Spain/epidemiology MH - Aged MH - Risk Factors MH - Adolescent MH - Young Adult MH - Risk Assessment PMC - PMC13028122 OTO - NOTNLM OT - cardiometabolic health OT - diabetes risk scores OT - occupational population OT - psychosocial factors OT - purpose in life OT - type 2 diabetes risk COIS- The authors declare no conflicts of interest. EDAT- 2026/03/27 17:37 MHDA- 2026/03/27 17:38 PMCR- 2026/02/26 CRDT- 2026/03/27 11:22 PHST- 2026/01/30 00:00 [received] PHST- 2026/02/16 00:00 [revised] PHST- 2026/02/25 00:00 [accepted] PHST- 2026/03/27 17:38 [medline] PHST- 2026/03/27 17:37 [pubmed] PHST- 2026/03/27 11:22 [entrez] PHST- 2026/02/26 00:00 [pmc-release] AID - medsci14010113 [pii] AID - medsci-14-00113 [pii] AID - 10.3390/medsci14010113 [doi] PST - epublish SO - Med Sci (Basel). 2026 Feb 26;14(1):113. doi: 10.3390/medsci14010113. PMID- 41892778 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260327 LR - 20260813 IS - 2304-6767 (Electronic) IS - 2304-6767 (Linking) VI - 14 IP - 3 DP - 2026 Mar 16 TI - Predicting Dental Anxiety and Cooperative Behavior in Children Using Machine Learning: A Cross-Sectional Predictive Modeling Study. LID - 10.3390/dj14030170 [doi] LID - 170 AB - Background/Objectives: Dental anxiety and uncooperative behavior present significant challenges in pediatric dentistry and may adversely affect treatment outcomes and oral health. The main goal of this study was to evaluate the predictive performance of machine learning models in classifying dental anxiety measured using the Abeer Children Dental Anxiety Scale (ACDAS), predicting uncooperative behavior, estimating continuous dental anxiety scores, and identifying key predictors among children aged 6-11 years attending pediatric dental clinics in Jeddah, Saudi Arabia. Methods: This is an analytical cross-sectional study conducted among 952 children to evaluate whether machine learning models could predict dental anxiety and cooperative behavior based on demographic, clinical, and behavioral variables. Twenty variables captured demographic, medical, and dental history, BMI, and anxiety/behavioral measures. Data preprocessing included removing sparse variables, imputing missing values, and encoding categorical and ordinal variables appropriately. Logistic Regression models were trained to classify dental anxiety and cooperative behavior. A Random Forest Regressor was used to predict continuous anxiety scores, and a Random Forest Classifier was used for feature importance analysis. Principal Component Analysis (PCA) and K-Means clustering were applied to explore behavioral subgroups. Results: This dataset shows the Logistic Regression model with 0.92 accuracy (ROC AUC 0.98) for predicting dental anxiety and 0.91 accuracy (ROC AUC 0.95) for cooperative behavior. The Random Forest Regressor predicted anxiety scores with R(2) = 0.97. Feature importance revealed that sensory and cognitive responses were key predictors of anxiety and cooperation. Unsupervised clustering identified two behavioral profiles: one with lower and another with higher anxiety and cooperation. Conclusions: ML models demonstrated strong prediction of dental anxiety and cooperation in this pediatric sample. While promising for early detection and personalized management of anxious or uncooperative children, further validation is essential before clinical use. FAU - Helal, Narmin M AU - Helal NM AUID- ORCID: 0000-0002-3194-7358 AD - Pediatric Dentistry Department, King Abdulaziz University, Jeddah 21589, Saudi Arabia. FAU - Sabbagh, Heba AU - Sabbagh H AUID- ORCID: 0000-0002-9788-0379 AD - Pediatric Dentistry Department, King Abdulaziz University, Jeddah 21589, Saudi Arabia. LA - eng GR - IPP; 237-165-2025/This project was funded by the Deanship of Scientific Research (DSR) at King Abdulaziz University/ PT - Journal Article DEP - 20260316 PL - Switzerland TA - Dent J (Basel) JT - Dentistry journal JID - 101716125 PMC - PMC13025896 OTO - NOTNLM OT - cooperative behavior OT - dental anxiety OT - machine learning OT - pediatric dentistry OT - predictive modeling COIS- The authors declare no conflict of interest. EDAT- 2026/03/27 17:38 MHDA- 2026/03/27 17:39 PMCR- 2026/03/16 CRDT- 2026/03/27 11:17 PHST- 2026/01/29 00:00 [received] PHST- 2026/02/23 00:00 [revised] PHST- 2026/03/10 00:00 [accepted] PHST- 2026/03/27 17:39 [medline] PHST- 2026/03/27 17:38 [pubmed] PHST- 2026/03/27 11:17 [entrez] PHST- 2026/03/16 00:00 [pmc-release] AID - dj14030170 [pii] AID - dentistry-14-00170 [pii] AID - 10.3390/dj14030170 [doi] PST - epublish SO - Dent J (Basel). 2026 Mar 16;14(3):170. doi: 10.3390/dj14030170. PMID- 41888969 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260627 LR - 20260813 IS - 0778-7367 (Print) IS - 2049-3258 (Electronic) IS - 0778-7367 (Linking) VI - 84 IP - 1 DP - 2026 Mar 26 TI - Study protocol for Valor Barroso: a mixed-method approach to dietary-physical activity patterns in Barroso, Portugal. LID - 10.1186/s13690-026-01900-8 [doi] LID - 101 AB - AIM: This community-based mixed-methods study aims to evaluate the dietary habits and physical activity patterns of the Barroso population in northern Portugal. METHODS: This study was divided into two phases. The quantitative phase will be a cross-sectional study involving 416 participants from different age groups, including children, adolescents, adults, and elderly individuals. Sociodemographic and clinical, including anthropometric measurements, blood pressure, and quality of life, will be collected. Physical activity will be assessed wGT3X+ Actigraph accelerometers and validated questionnaires, whereas dietary habits will be evaluated via food frequency questionnaires, 24-hour dietary recalls, and food diaries. In the qualitative phase, participants will be selected through stratified sampling and ethnographic analysis will be conducted through observations and semi-structured interviews to explore the cultural, social, and environmental factors influencing dietary habits and physical activity in the local population. DISCUSSION: By integrating objective measures of physical activity and diet, such as accelerometers and validated questionnaires, with qualitative data on cultural and traditional practices, this study aims to provide a more comprehensive understanding of lifestyle behaviors in the region and their associations with health. Additionally, the study investigated how geographical, socioeconomic, and cultural contexts influence these dietary and physical activity behaviors. The conclusions drawn will help develop public health interventions to improve health outcomes in rural communities and will contribute to the development of more effective strategies for similar populations. FAU - Cortez-Ribeiro, Anna Carolina AU - Cortez-Ribeiro AC AD - CIMO, LA SusTEC, Instituto Politecnico de Braganca, Campus de Santa Apolonia, Braganca, 5300- 253, Portugal. AD - Centro de Investigacao em Actividade Fisica Saude e Lazer (CIAFEL), Faculdade de Desporto, Universidade do Porto, Rua Dr. Placido da Costa, 91, Porto, 4200-450, Portugal. FAU - Ribeiro, Jose Carlos AU - Ribeiro JC AD - Centro de Investigacao em Actividade Fisica Saude e Lazer (CIAFEL), Faculdade de Desporto, Universidade do Porto, Rua Dr. Placido da Costa, 91, Porto, 4200-450, Portugal. AD - Laboratorio para a Investigacao Integrativa e Translacional em Saude Populacional (ITR), Universidade do Porto, Rua das Taipas, 135, Porto, 4050-600, Portugal. FAU - Alves, Maria Jose AU - Alves MJ AD - Centro de Valorizacao e Transferencia de Tecnologia da Agua, AquaValor, Rua Dr. Julio Martins, 1, Chaves, 5400-342, Portugal. AD - LiveWell - Research Centre for Active Living & Wellbeing, Instituto Politecnico de Braganca, Campus de Santa Apolonia, Braganca, 5300- 253, Portugal. FAU - Ferro-Lebres, Vera AU - Ferro-Lebres V AD - CIMO, LA SusTEC, Instituto Politecnico de Braganca, Campus de Santa Apolonia, Braganca, 5300- 253, Portugal. vferrolebres@ipb.pt. LA - eng GR - PRT/BD/154584/2023/Fundacao para a Ciencia e a Tecnologia/ GR - UIDB/00617/2020 (DOI: 10.54499/UIDB/00617/2020) and UIDP/00617/2020 (DOI: 10.54499/UIDP/00617/20);/Fundacao para a Ciencia e a Tecnologia/ GR - CIMO, UIDB/00690/2020 (DOI: 10.54499/UIDB/00690/2020) and UIDP/00690/2020 (DOI: 10.54499/UIDP/00690/2020); SusTEC, LA/P/0007/2020 (DOI: 10.54499/LA/P/0007/2020)/Fundacao para a Ciencia e a Tecnologia/ PT - Journal Article DEP - 20260326 PL - England TA - Arch Public Health JT - Archives of public health = Archives belges de sante publique JID - 9208826 PMC - PMC13147682 OTO - NOTNLM OT - Dietary patterns OT - Lifestyle OT - Physical activity OT - Public health OT - Rural population COIS- Declarations. Ethical approval and consent to participate: This study was approved by the Ethics Committee of the Instituto Politecnico de Braganca (P545795-R674918-D2059383). All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Consent for participating will be obtained from all participants after data collection. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/27 07:15 MHDA- 2026/03/27 07:16 PMCR- 2026/03/26 CRDT- 2026/03/27 01:14 PHST- 2025/09/30 00:00 [received] PHST- 2026/03/12 00:00 [accepted] PHST- 2026/03/27 07:16 [medline] PHST- 2026/03/27 07:15 [pubmed] PHST- 2026/03/27 01:14 [entrez] PHST- 2026/03/26 00:00 [pmc-release] AID - 10.1186/s13690-026-01900-8 [pii] AID - 1900 [pii] AID - 10.1186/s13690-026-01900-8 [doi] PST - epublish SO - Arch Public Health. 2026 Mar 26;84(1):101. doi: 10.1186/s13690-026-01900-8. PMID- 41888855 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Mar 27 TI - Turkish adaptation and validation of the Eating Disorders Examination Questionnaire - Short Parent Version (EDE-QS-P). LID - 10.1186/s40359-026-04397-6 [doi] LID - 656 AB - BACKGROUND: Eating disorders are complex psychiatric conditions characterized by intense concerns related to body image and weight. Adolescents and school-aged children are considered at risk due to their developmental characteristics. However, difficulties in recognizing and expressing symptoms within this age group often complicate the diagnostic process. Parent-reported assessment tools play a crucial role in monitoring eating behaviours and supporting early intervention. Therefore, cultural adaptation and psychometric evaluation of eating disorders scales designed for children and adolescents are essential for enhancing the effectiveness of early diagnosis. This study aims to evaluate the validity and reliability of the Turkish version of the Eating Disorders Examination Questionnaire - Short Parent Version (EDE-QS-P), which was developed to assess eating disorder symptoms in children and adolescents. METHOD: This cross-sectional validity and reliability study was conducted with a total of 516 participants from two schools located in the Aegean region of Turkiye. Data were collected through face-to-face interviews. The original scale, consists of 11 items, is answered using a 4-point Likert scale, and yields a total score ranging from 0 to 33. Data analysis included confirmatory factor analysis, content validity index (CVI), Cronbach's alpha coefficient, McDonald's omega coefficient, test-retest method, and split-half reliability method. RESULTS: In the study, the mean total score of the scale was determined as 3.73 +/- 5.79. The CVI was found to be 0.99, and confirmatory factor analysis results indicated a good model fit (RMSEA = 0.075; chi(2)/df = 4.902; CFI = 0.97). In the reliability analysis, Cronbach's alpha coefficient was calculated as 0.882 and McDonald's omega as 0.891. Test-retest results showed no statistically significant difference (p > 0.05). CONCLUSIONS: The Turkish version of the scale was found to have valid and reliable internal consistency. The findings support that the Turkish version of the scale is an effective assessment tool for monitoring eating disorder symptoms in children and adolescents. FAU - Pekparmak-Alevli, Gamze AU - Pekparmak-Alevli G AD - Department of Nutrition and Dietetics, Institute of Health Sciences, Izmir Katip Celebi University, Izmir, Turkiye. FAU - Yildirim, Julide Gulizar AU - Yildirim JG AD - Department of Public Health Nursing, Faculty of Health Sciences, Izmir Katip Celebi University, Izmir, Turkiye. FAU - Yurtdas-Depboylu, Gamze AU - Yurtdas-Depboylu G AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Izmir Katip Celebi University, Izmir, Turkiye. FAU - Kaner, Gulsah AU - Kaner G AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Izmir Katip Celebi University, Izmir, Turkiye. gulsah.kaner@ikcu.edu.tr. LA - eng PT - Journal Article PT - Validation Study DEP - 20260327 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Turkey MH - Reproducibility of Results MH - *Psychometrics MH - *Feeding and Eating Disorders/diagnosis MH - Female MH - Child MH - Adolescent MH - *Parents MH - Surveys and Questionnaires/standards MH - Male MH - Cross-Sectional Studies MH - *Psychiatric Status Rating Scales/standards PMC - PMC13147684 OTO - NOTNLM OT - Adolescents OT - Eating disorders OT - Reliability OT - School-aged children OT - Validity COIS- Declarations. Ethics approval and consent to participate: This study was initiated after receiving approval from the Non-Interventional Clinical Research Ethics Committee at Izmir Katip Celebi University to ensure compliance with ethical standards. Prospective participants were adequately informed about the study, and written informed consent was obtained from those who voluntarily agreed to participate, in accordance with the principles outlined in the Declaration of Helsinki. Permission to conduct the study was also obtained in writing from the Izmir Provincial Directorate of National Education, Ministry of National Education of the Republic of Turkiye. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/27 07:14 MHDA- 2026/06/28 04:09 PMCR- 2026/03/27 CRDT- 2026/03/27 01:07 PHST- 2025/08/07 00:00 [received] PHST- 2026/03/17 00:00 [accepted] PHST- 2026/06/28 04:09 [medline] PHST- 2026/03/27 07:14 [pubmed] PHST- 2026/03/27 01:07 [entrez] PHST- 2026/03/27 00:00 [pmc-release] AID - 10.1186/s40359-026-04397-6 [pii] AID - 4397 [pii] AID - 10.1186/s40359-026-04397-6 [doi] PST - epublish SO - BMC Psychol. 2026 Mar 27;14(1):656. doi: 10.1186/s40359-026-04397-6. PMID- 41888252 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Mar 27 TI - Risk assessment for type 2 diabetes mellitus and its association with knowledge and health beliefs among university students in three Arab countries. LID - 10.1038/s41598-026-41511-5 [doi] LID - 10367 AB - Type 2 diabetes mellitus (T2DM) is a growing concern in the Arab world, with university students increasingly at risk due to lifestyle factors. This study aims to assess T2DM risk, knowledge, and beliefs among university students aged >/= 18 years in Egypt, Saudi Arabia, and Yemen. A multinational, cross-sectional study was conducted from January to April 2025 among university students aged >/= 18 years in Egypt (lower-middle-income), Saudi Arabia (high-income), and Yemen (low-income). A multistage, stratified purposive sampling technique was used to recruit students equally from medical and non-medical faculties in at least three universities per country. Data were collected via structured, interview-based questionnaires consisting of four components: (1) socio-demographic and anthropometric data; (2) the Diabetes Knowledge Questionnaire-18 (DKQ-18); (3) the Health Belief Model Scale (HBMS); and (4) the validated Arabic version of the Australian type 2 diabetes risk assessment tool (AUSDRISK). Among 2787 university students, the mean age was 21.0 years, with the majority being female (74.9%), and enrolled in medical faculties (58.2%). Diabetes knowledge was significantly higher in Egyptians (72.6% with good knowledge) compared to Saudis (63.9%) and Yemenis (59.8%) (p < 0.001). Health beliefs followed a similar trend, while diabetes risk was significantly higher among Yemeni students (22.0% with severe risk; p < 0.001). Multiple regression analysis revealed that a higher academic year was a positive predictor of both diabetes knowledge (beta = 0.155, p < 0.001) and health beliefs (beta = 0.152, p < 0.001), and was negatively associated with diabetes risk (beta = - 0.061, p < 0.001). Medical faculty enrollment was also positively associated with knowledge (beta = - 0.411 for non-medical faculty, p < 0.001) and beliefs (beta = - 0.228 for non-medical faculties, p < 0.001). Parental education and income were positively associated with knowledge and beliefs. Specifically, father's higher education predicted greater knowledge (beta = 0.047, p < 0.001), and household income was a significant predictor of both knowledge (beta = 0.042, p < 0.001) and beliefs (p < 0.001). In contrast, diabetes risk was independently associated with male gender (beta = 0.305, p < 0.001), older age (beta = 0.123, p < 0.001), higher BMI (beta = 0.284, p < 0.001), and Yemeni nationality (beta = 0.080, p < 0.001). Marked differences in diabetes risk, knowledge, and beliefs were observed among students from the three countries. Interventions targeting high-risk groups are essential to improve diabetes awareness and prevention in young adults. Countries like Yemen may benefit from urgent preventive measures, while countries with moderate risk profiles may focus on health promotion and sustained education to avert future disease burdens. FAU - Ahmed, Hebatalla Abdelmaksoud Abdelmonsef AU - Ahmed HAA AUID- ORCID: 0000-0002-1882-6623 AD - Public Health & Community Medicine Department, Faculty of Medicine, Kafr-Elsheikh University, Kafr El Sheikh, Egypt. Heba_Abdelmasoud@med.kfs.edu.eg. FAU - Yousef, Ahmed AU - Yousef A AD - Public Health & Community Medicine Department, Damietta Faculty of Medicine, Al-Azhar University, Cairo, Egypt. FAU - Abdelwahab, Shady Mohamed AU - Abdelwahab SM AD - Faculty of Medicine, Kafr-Elsheikh University, Kafr El Sheikh, Egypt. FAU - Youssef, Mohamed Adel AU - Youssef MA AD - Faculty of Medicine, Kafr-Elsheikh University, Kafr El Sheikh, Egypt. FAU - Elnozahy, Samah Shalaby AU - Elnozahy SS AD - Faculty of Medicine, Kafr-Elsheikh University, Kafr El Sheikh, Egypt. FAU - Almater, Reema Saeed AU - Almater RS AD - Faculty of Medicine, King Khalid University, El-Qassem, Kingdom of Saudi Arabia. FAU - Saddah, Lamia Ahmed AU - Saddah LA AD - Faculty of Medicine, King Khalid University, El-Qassem, Kingdom of Saudi Arabia. FAU - Al-Dhawi, Methqal AU - Al-Dhawi M AUID- ORCID: 0009-0009-7450-036X AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. FAU - Al-Matari, Noor Ebrahim Naji AU - Al-Matari NEN AD - Faculty of Medicine, Al-azhar University, Cairo, Egypt. FAU - Al-Azab, Mohammed AU - Al-Azab M AUID- ORCID: 0009-0000-0430-9767 AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. FAU - Shiba, Hoda Ali Ahmed AU - Shiba HAA AUID- ORCID: 0000-0001-8147-3034 AD - Public Health & Community Medicine Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. LA - eng PT - Journal Article DEP - 20260327 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/epidemiology MH - Female MH - Male MH - *Health Knowledge, Attitudes, Practice MH - Universities MH - *Students/psychology MH - Young Adult MH - Cross-Sectional Studies MH - Egypt/epidemiology MH - Risk Assessment MH - Saudi Arabia/epidemiology MH - Surveys and Questionnaires MH - Adult MH - Yemen/epidemiology MH - Risk Factors MH - Adolescent MH - Middle Eastern People MH - Arabs PMC - PMC13031495 OTO - NOTNLM OT - Arab countries OT - Diabetes knowledge AUSDRISK OT - Health beliefs OT - Type 2 diabetes OT - University students COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical considerations: The study was approved by the Damietta Faculty of Medicine IRB at Azhar University, Egypt (Study ID: DFM-IRB 00012367-25-05-001), and by the Faculty of Medicine & Health Sciences IRB at Sana'a University, Republic of Yemen (Study ID: 2025 (4) 8). In addition, official permissions were obtained from the deans of the participating faculties in Egypt, Yemen, and Saudi Arabia prior to data collection. The study was executed by the ethical standards laid down in the 1964 Declaration of Helsinki and its later modifications. Informed consent was obtained from all the subjects involved in the study. All participants were given information on the study's purpose, anonymity, confidentiality, voluntary participation, and privacy statements. Confidentiality had been emphasized throughout the study period. EDAT- 2026/03/27 07:15 MHDA- 2026/06/28 04:09 PMCR- 2026/03/27 CRDT- 2026/03/27 00:25 PHST- 2025/07/12 00:00 [received] PHST- 2026/02/20 00:00 [accepted] PHST- 2026/06/28 04:09 [medline] PHST- 2026/03/27 07:15 [pubmed] PHST- 2026/03/27 00:25 [entrez] PHST- 2026/03/27 00:00 [pmc-release] AID - 10.1038/s41598-026-41511-5 [pii] AID - 41511 [pii] AID - 10.1038/s41598-026-41511-5 [doi] PST - epublish SO - Sci Rep. 2026 Mar 27;16(1):10367. doi: 10.1038/s41598-026-41511-5. PMID- 41887121 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 1878-5506 (Electronic) IS - 1389-9457 (Print) IS - 1389-9457 (Linking) VI - 143 DP - 2026 Jul TI - Biphasic sleep is a feature of sleep disturbance in SYNGAP1-RD. PG - 108908 LID - S1389-9457(26)00147-4 [pii] LID - 10.1016/j.sleep.2026.108908 [doi] AB - STUDY OBJECTIVES: Sleep problems are common in children with SYNGAP1-Related Disorder (SYNGAP1-RD). The use of devices that objectively estimate sleep are complicated by co-occurring sensory disorders in this population. We examined the feasibility and validity of wrist actigraphy to examine sleep and rest-activity rhythms (RAR). METHODS: Data from five children with SYNGAP1-RD and 42 typically developing children were analyzed. All children were asked to wear the Actiwatch-2 for 14 continuous days and caregivers were asked to complete a sleep diary and the Children Sleep Health Questionnaire (CSHQ). Parametric (alpha, beta, acrophase, amplitude, up/down mesor, mesor), nonparametric (intradaily variability, interdaily stability, M10/L5 and relative amplitude), and sleep metrics-total sleep time (TST), wake after sleep onset (WASO), fragmentation index (restlessness throughout the rest period), the time of sleep bout onset, the number, and duration of sleep bouts, and the number and duration of wake bouts-were analyzed. RESULTS: In children with SYNGAP1-RD, sleep bouts were distributed across the day and night and were consistent with a higher alpha. Fewer sleep bouts occurred in the early morning aligning with parent report of early morning arousal. Although there was no difference in average TST, children with SYNGAP1-RD, had fewer sleep and wake bouts that were longer in duration. Additionally, they had greater WASO and higher fragmentation index, the latter was a strong predictor of subjects with SYNGAP1-RD. CONCLUSION: Actigraphy provides an objective measure of sleep that aligns with RAR, is consistent with parent report, and provides an ethological approach to monitoring sleep in children with SYNGAP1-RD. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Doucoure, Aida AU - Doucoure A AD - Neurology and Developmental Medicine, Kennedy Krieger Institute, 707 N Broadway, 21205, Baltimore, MD, USA. FAU - Patel, Het AU - Patel H AD - Neurology and Developmental Medicine, Kennedy Krieger Institute, 707 N Broadway, 21205, Baltimore, MD, USA. FAU - Abboud, Mark A AU - Abboud MA AD - Departments of Neurology, Neuroscience and Psychiatry & Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. FAU - Sperry, Alice AU - Sperry A AD - Center for Neurodevelopmental and Imaging Research (CNIR), Kennedy Krieger Institute Baltimore Maryland, USA. FAU - Wanigatunga, Sarah K AU - Wanigatunga SK AD - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 2024 E. Monument St., Rm B309, Baltimore, MD, 21205, USA. FAU - Crocetti, Deana AU - Crocetti D AD - Center for Neurodevelopmental and Imaging Research (CNIR), Kennedy Krieger Institute Baltimore Maryland, USA. FAU - Volk, Heather AU - Volk H AD - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 2024 E. Monument St., Rm B309, Baltimore, MD, 21205, USA. FAU - Spira, Adam P AU - Spira AP AD - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 2024 E. Monument St., Rm B309, Baltimore, MD, 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 707 N Broadway, 21205, Baltimore, MD, USA; Johns Hopkins Center on Aging and Health, 2024 E. Monument Street, 21205, Baltimore, MD, USA. FAU - Mostofsky, Stewart H AU - Mostofsky SH AD - Department of Neurology Johns Hopkins University School of Medicine, USA; Center for Neurodevelopmental and Imaging Research (CNIR), Kennedy Krieger Institute Baltimore Maryland, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 707 N Broadway, 21205, Baltimore, MD, USA. FAU - Krishnan, Vaishnav AU - Krishnan V AD - Departments of Neurology, Neuroscience and Psychiatry & Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. FAU - Smith-Hicks, Constance AU - Smith-Hicks C AD - Neurology and Developmental Medicine, Kennedy Krieger Institute, 707 N Broadway, 21205, Baltimore, MD, USA; Department of Neurology Johns Hopkins University School of Medicine, USA. Electronic address: hicksc@kennedykrieger.org. LA - eng GR - K08 NS110924/NS/NINDS NIH HHS/United States GR - P50 HD103538/HD/NICHD NIH HHS/United States GR - R01 NS113140/NS/NINDS NIH HHS/United States GR - R01 NS131399/NS/NINDS NIH HHS/United States PT - Journal Article DEP - 20260320 PL - Netherlands TA - Sleep Med JT - Sleep medicine JID - 100898759 RN - 0 (ras GTPase-Activating Proteins) RN - 0 (SYNGAP1 protein, human) SB - IM MH - Humans MH - Actigraphy/methods MH - Female MH - Male MH - *Sleep Wake Disorders/physiopathology/genetics MH - Child MH - Sleep Duration MH - *ras GTPase-Activating Proteins/genetics MH - Surveys and Questionnaires MH - *Sleep/physiology PMC - PMC13288264 MID - NIHMS2161377 OTO - NOTNLM OT - Actigraphy OT - Nonparametric OT - Parametric OT - Rest-activity-rhythms OT - SYNGAP1-RD OT - Sleep disturbances COIS- Declaration of competing interest Adam Spira has served as a consultant to Sequoia Neurovitality, BellSant, Inc., Amissa, Inc., and Synaptic Health, LLC. EDAT- 2026/03/27 01:10 MHDA- 2026/04/26 05:13 PMCR- 2026/06/23 CRDT- 2026/03/26 19:14 PHST- 2026/02/18 00:00 [received] PHST- 2026/03/17 00:00 [revised] PHST- 2026/03/19 00:00 [accepted] PHST- 2026/04/26 05:13 [medline] PHST- 2026/03/27 01:10 [pubmed] PHST- 2026/03/26 19:14 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - S1389-9457(26)00147-4 [pii] AID - 10.1016/j.sleep.2026.108908 [doi] PST - ppublish SO - Sleep Med. 2026 Jul;143:108908. doi: 10.1016/j.sleep.2026.108908. Epub 2026 Mar 20. PMID- 41886938 OWN - NLM STAT- MEDLINE DCOM- 20260722 LR - 20260722 IS - 1873-6297 (Electronic) IS - 0001-6918 (Linking) VI - 265 DP - 2026 May TI - Effectiveness of yoga training program as a pre-exercise activity on sport anxiety and athletic mental energy in adolescent football players. PG - 106690 LID - S0001-6918(26)00491-9 [pii] LID - 10.1016/j.actpsy.2026.106690 [doi] AB - This study examined whether embedding a brief pre-exercise yoga routine into warm-ups relates to lower sport anxiety and higher athletic mental energy in Chinese adolescent football players, and whether these links operate through mindfulness in sport and vary by weekly training load. In a multi-site sample (N = 468; Wuhan, Hangzhou, Nanjing, Xi'an), athletes completed validated instruments: Sport Anxiety Scale-2, Athletic Mental Energy Scale, Mindfulness Inventory for Sport, Yoga Self-Efficacy Scale, and a short form of interoceptive/body awareness; pre-exercise yoga engagement was modeled formatively (frequency, duration, adherence, intensity), and weekly training load was indexed as seven-day session-RPE x minutes. SmartPLS (v4) was used for PLS-SEM with 5000 bootstraps. The measurement model showed strong reliability and validity (composite reliability >/=0.91; AVE >/= 0.58; HTMT <0.85; Fornell-Larcker satisfied; full-collinearity VIFs <3.3). Pre-exercise yoga practice was also linked with reduced sport anxiety (beta = -0.16, p = 0.003), and increased athletic mental energy (2 = 0.14, p = 0.005); yoga self-efficacy was more strongly linked (2 = -0.20, and 2 = 0.24, both p = 0.001), and lower interoceptive/body awareness was more weakly correlated (2 = -0.11 and 2 = 0.12, both = 0.027). The indirect relationships between the predictors and the outcomes of mindfulness in sport were also significantly large, which is in line with the hypothesized mechanistic pattern. The weekly training load moderated a number of engagement and self-efficacy associations (|human| > Some associations between them were stronger under heavier load (=0.07-0.09, p = 0.048). These results indicate the existence of warm-up-compatible, formatively specified yoga exposure and practically significant load boundary, yet are still consistent with the cross-sectional design of the study... Demographic covariates were non-significant. The study's novelty lies in a warm-up-compatible, formatively specified yoga exposure, a single mechanistic mediator, and a practical load boundary, offering a scalable pathway to reduce anxiety and enhance mental energy without extending training time. CI - Copyright (c) 2024. Published by Elsevier B.V. FAU - Yu, Qun AU - Yu Q AD - School of Physical Education, Yancheng Teachers University, Yancheng, 224000, China. Electronic address: yuq01@yctu.edu.cn. FAU - Liu, Zheng AU - Liu Z AD - School of Education, Anshun University, Anshun, 561000, China. Electronic address: Qunyu.yq@163.com. LA - eng PT - Journal Article DEP - 20260325 PL - Netherlands TA - Acta Psychol (Amst) JT - Acta psychologica JID - 0370366 SB - IM MH - China MH - *Soccer/psychology MH - *Yoga/psychology MH - *Performance Anxiety/prevention & control/psychology MH - *Athletic Performance/psychology MH - *Athletes/psychology MH - Humans MH - Male MH - Adolescent MH - Mindfulness MH - Exercise/psychology OTO - NOTNLM OT - Adolescent football players OT - Athletic mental energy OT - Mindfulness in sport OT - Pre-exercise yoga OT - Sport anxiety COIS- Declaration of competing interest The authors declare no conflict of interest. EDAT- 2026/03/27 01:10 MHDA- 2026/04/19 17:46 CRDT- 2026/03/26 19:06 PHST- 2025/09/04 00:00 [received] PHST- 2026/02/24 00:00 [revised] PHST- 2026/03/13 00:00 [accepted] PHST- 2026/04/19 17:46 [medline] PHST- 2026/03/27 01:10 [pubmed] PHST- 2026/03/26 19:06 [entrez] AID - S0001-6918(26)00491-9 [pii] AID - 10.1016/j.actpsy.2026.106690 [doi] PST - ppublish SO - Acta Psychol (Amst). 2026 May;265:106690. doi: 10.1016/j.actpsy.2026.106690. Epub 2026 Mar 25. PMID- 41885132 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260824 IS - 1463-1326 (Electronic) IS - 1462-8902 (Linking) VI - 28 IP - 6 DP - 2026 Jun TI - Safety of GLP-1 and Dual GLP-1/GIP Receptor Agonists in Preconception, Pregnancy, and Lactation: A Systematic Review of Maternal, Fetal, and Neonatal Outcomes. PG - 4503-4528 LID - 10.1111/dom.70699 [doi] AB - BACKGROUND AND AIM: Use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) receptor agonists is increasing among reproductive-aged women for obesity, diabetes, polycystic ovary syndrome (PCOS), and cardiometabolic disease. However, the safety of these agents in pregnancy and lactation remains sparse, while inadvertent first-trimester exposure is becoming more common. The aim of this review is to systematically evaluate maternal, fetal, neonatal, and lactation outcomes following preconception, in-pregnancy, or postpartum exposure to GLP-1 and dual GLP-1/GIP receptor agonists. METHODS: We conducted a systematic review of PubMed/MEDLINE, Web of Science, Scopus, and the Cochrane Library from inception to 23 September 2025. Human studies reporting exposure to GLP-1 or dual GLP-1/GIP receptor agonists during preconception, pregnancy, or lactation were included. Two reviewers independently screened studies, extracted data, and assessed risk of bias using validated tools. Given clinical heterogeneity, findings were synthesised narratively in accordance with PRISMA 2020 guidelines. RESULTS: Thirty-six studies met the inclusion criteria. Across large observational cohorts, periconceptional or early-pregnancy exposure to GLP-1-based therapies was not consistently associated with increased risk of major congenital malformations in adjusted analyses, fetal growth restriction, stillbirth, or neonatal mortality compared with insulin-treated or disease-matched controls. Maternal outcomes, including gestational diabetes, hypertensive disorders of pregnancy, preterm birth, and gestational weight gain, were heterogeneous without a reproducible safety signal. Indeed, in women with PCOS, GLP-1RAs seem promising in various aspects. Lactation data were sparse; one pharmacokinetic study reported no detectable semaglutide transfer into human milk. CONCLUSION: Current evidence suggests that preconceptional or early-pregnancy exposure to GLP-1-based therapies is not consistently associated with increased maternal, fetal, or neonatal risk, although data on continued use throughout gestation remain limited. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Ozbek, Lasin AU - Ozbek L AUID- ORCID: 0000-0002-2828-555X AD - Department of Medicine, Koc University School of Medicine, Istanbul, Turkey. FAU - Shah, Ermeena AU - Shah E AUID- ORCID: 0009-0008-8759-7992 AD - Department of Medicine, Koc University School of Medicine, Istanbul, Turkey. FAU - Al-Shiab, Rama AU - Al-Shiab R AUID- ORCID: 0009-0009-0741-893X AD - Department of Medicine, Koc University School of Medicine, Istanbul, Turkey. FAU - Inal, Azra AU - Inal A AD - Department of Medicine, Koc University School of Medicine, Istanbul, Turkey. FAU - Guldan, Mustafa AU - Guldan M AUID- ORCID: 0000-0002-0480-5370 AD - Department of Medicine, Koc University School of Medicine, Istanbul, Turkey. FAU - Afsar, Baris AU - Afsar B AUID- ORCID: 0000-0002-1369-3657 AD - Department of Medicine, Division of Nephrology, Suleyman Demirel University School of Medicine, Istanbul, Turkey. FAU - Covic, Adrian AU - Covic A AUID- ORCID: 0000-0002-9985-2486 AD - Department of Medicine, Division of Nephrology, Grigore T. Popa University of Medicine and Pharmacy Iasi, Iasi, Romania. FAU - Kanbay, Mehmet AU - Kanbay M AUID- ORCID: 0000-0002-1297-0675 AD - Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260326 PL - England TA - Diabetes Obes Metab JT - Diabetes, obesity & metabolism JID - 100883645 RN - D6H00MV7K8 (gastric inhibitory polypeptide receptor) RN - 0 (Glucagon-Like Peptide-1 Receptor Agonists) RN - 0 (Hypoglycemic Agents) RN - 0 (Receptors, Gastrointestinal Hormone) SB - IM MH - Female MH - Humans MH - Infant, Newborn MH - Pregnancy MH - *Glucagon-Like Peptide-1 Receptor Agonists MH - *Hypoglycemic Agents/adverse effects MH - *Lactation/drug effects MH - Pregnancy Outcome/epidemiology MH - *Receptors, Gastrointestinal Hormone/agonists OTO - NOTNLM OT - GLP-1 receptor agonists OT - congenital anomalies OT - drug safety OT - dual GLP-1/GIP receptor agonists OT - lactation OT - maternal outcomes OT - neonatal outcomes OT - preconception counselling OT - pregnancy EDAT- 2026/03/26 13:31 MHDA- 2026/05/06 06:40 CRDT- 2026/03/26 06:43 PHST- 2026/03/04 00:00 [revised] PHST- 2026/01/19 00:00 [received] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/05/06 06:40 [medline] PHST- 2026/03/26 13:31 [pubmed] PHST- 2026/03/26 06:43 [entrez] AID - 10.1111/dom.70699 [doi] PST - ppublish SO - Diabetes Obes Metab. 2026 Jun;28(6):4503-4528. doi: 10.1111/dom.70699. Epub 2026 Mar 26. PMID- 41884688 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260326 LR - 20260813 IS - 2325-9671 (Print) IS - 2325-9671 (Electronic) IS - 2325-9671 (Linking) VI - 14 IP - 3 DP - 2026 Mar TI - Mandarin Chinese Translation and Cross-Cultural Adaptation of the Hospital for Special Surgery Pediatric Functional Activity Brief Scale (Chinese HSS Pedi-FABS). PG - 23259671251408800 LID - 10.1177/23259671251408800 [doi] LID - 23259671251408800 AB - BACKGROUND: The Hospital for Special Surgery Pediatric Functional Activity Brief Scale (HSS Pedi-FABS), consisting of 8 simple questions, is a useful tool for quantifying children's physical activity for research and clinical practice. Because of cultural diversity and variation in native languages across regions, translation and cross-cultural adaptation of patient-reported outcome measures is required. PURPOSE: To translate, cross-culturally adapt, and validate a Chinese version of the HSS Pedi-FABS questionnaire. STUDY DESIGN: Cohort study (diagnosis); Level of evidence, 2. METHODS: The HSS Pedi-FABS was translated into Chinese following a standardized 5-step forward-backward protocol, including translation, synthesis, back translation, expert review, and pretesting. Healthy children aged 10 to 18 years completed the Chinese HSS Pedi-FABS along with the Physical Activity Questionnaire for Older Children (PAQ-C) or Physical Activity Questionnaire for Adolescents (PAQ-A) for construct validation. Test-retest reliability was assessed over a 7- to 30-day interval, internal consistency was measured using Cronbach alpha, and construct validity was evaluated using Pearson correlation coefficients. RESULTS: A total of 184 children aged 10 to 18 years participated. The Chinese HSS Pedi-FABS demonstrated excellent internal consistency (Cronbach alpha = .93) and test-retest reliability (ICC = 0.98). Strong correlations were observed with PAQ-C (r = 0.85) in participants aged 10 to 12 and PAQ-A (r = 0.89) in those aged 13 to 18 years, supporting construct validity. CONCLUSION: Our study demonstrated that the Chinese version of the HSS Pedi-FABS is a well-validated and reliable instrument for assessing physical activity among healthy Chinese-speaking children and adolescents. This work will assist future researchers in studying and developing physical activity-related outcome measures for Chinese-speaking children. CI - (c) The Author(s) 2026. FAU - Hong, Chih-Kai AU - Hong CK AUID- ORCID: 0000-0003-3231-1789 AD - Department of Orthopaedic Surgery, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. FAU - Tsai, Ru-Ting AU - Tsai RT AD - Cathay General Hospital, Taipei, Taiwan. FAU - Fabricant, Peter D AU - Fabricant PD AUID- ORCID: 0000-0002-8070-685X AD - Pediatric Orthopaedic Surgery Service, Hospital for Special Surgery, New York, New York, USA. FAU - Wang, Chi-Hsiu AU - Wang CH AD - Department of Nursing, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. FAU - Lee, Su-Ying AU - Lee SY AD - Department of Nursing, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. FAU - Shih, Chien-An AU - Shih CA AD - Department of Orthopaedic Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. FAU - Wang, Jou-Hua AU - Wang JH AUID- ORCID: 0009-0005-0475-2917 AD - Department of Orthopaedic Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. AD - Department of Orthopedics, National Cheng Kung University Hospital Dou-Liou Branch, College of Medicine, National Cheng Kung University, Yunlin, Taiwan. LA - eng PT - Journal Article DEP - 20260318 PL - United States TA - Orthop J Sports Med JT - Orthopaedic journal of sports medicine JID - 101620522 PMC - PMC13009762 OTO - NOTNLM OT - HSS Pedi-FABS OT - adolescent OT - cross-cultural adaptation OT - pediatric OT - physical activity COIS- One or more of the authors has declared the following potential conflict of interest or source of funding: This study was funded by National Cheng Kung University Hospital, Tainan, Taiwan (NCKUH-11404061) and National Science and Technology Council, Taiwan (112-2314-B-002-331-MY3). AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto. This study was approved by the institutional review board of National Cheng Kung University Hospital, Tainan, Taiwan (No. A-ER-114-267). EDAT- 2026/03/26 07:09 MHDA- 2026/03/26 07:10 PMCR- 2026/03/18 CRDT- 2026/03/26 05:07 PHST- 2025/10/24 00:00 [received] PHST- 2025/11/11 00:00 [accepted] PHST- 2026/03/26 07:10 [medline] PHST- 2026/03/26 07:09 [pubmed] PHST- 2026/03/26 05:07 [entrez] PHST- 2026/03/18 00:00 [pmc-release] AID - 10.1177_23259671251408800 [pii] AID - 10.1177/23259671251408800 [doi] PST - epublish SO - Orthop J Sports Med. 2026 Mar 18;14(3):23259671251408800. doi: 10.1177/23259671251408800. eCollection 2026 Mar. PMID- 41884030 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260326 LR - 20260813 IS - 2219-2808 (Print) IS - 2219-2808 (Electronic) IS - 2219-2808 (Linking) VI - 15 IP - 1 DP - 2026 Mar 9 TI - Interplay of childhood metabolic dysfunction-associated steatotic liver disease and obesity in the development of youth-onset type 2 diabetes. PG - 111030 LID - 10.5409/wjcp.v15.i1.111030 [doi] LID - 111030 AB - BACKGROUND: The global increase in childhood and adolescent obesity has significantly contributed to the rising prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) - a condition now recognized as a key metabolic complication in youth. MASLD significantly increases the risk of youth-onset type 2 diabetes (T2D), particularly among obese individuals. Its asymptomatic progression presents considerable challenges for timely diagnosis and intervention. AIM: To review epidemiology, pathophysiological mechanisms, and management strategies related to pediatric MASLD, exploring its interaction with obesity and youth-onset T2D. METHODS: A comprehensive literature search was conducted using PubMed, Scopus, and Google Scholar to identify peer-reviewed studies published between 2015 and 2025. Keywords included "pediatric MASLD", "childhood obesity", "youth-onset type 2 diabetes", "hepatic insulin resistance", and "noninvasive biomarkers". Articles were selected based on relevance, methodological quality, and focus on human pediatric populations. RESULTS: MASLD affects approximately 13% of children globally and up to 47% of those with obesity, with the highest prevalence reported in urban areas of the United States, China, and India. In children and adolescents, excess adiposity is the leading contributor to hepatic steatosis and metabolic dysfunction, particularly when body mass exceeds standard growth benchmarks for age and sex. MASLD increases the risk of adolescent T2D by approximately 2.7-fold. Key pathophysiological mechanisms include hepatic insulin resistance, mitochondrial dysfunction, and chronic inflammation, driven by lipotoxic metabolites such as ceramides and pro-inflammatory cytokines. Lifestyle modifications - particularly low free-sugar diets and structured physical activity - have demonstrated moderate efficacy in reducing hepatic fat and improving metabolic outcomes. Pharmacologic interventions, including glucagon-like peptide-1 receptor agonists such as liraglutide and semaglutide, show potential for weight reduction and glycemic control, though their effects on hepatic histology remain under investigation. CONCLUSION: MASLD represents a critical metabolic threat in pediatric populations, strongly influenced by obesity and closely associated with increased risk of youth-onset T2D. Effective management requires early detection, multidisciplinary interventions, and equitable access to care. Future research should prioritize the validation of noninvasive diagnostic tools, development of targeted therapies, and reduction of socioeconomic and ethnic disparities in disease burden and treatment outcomes. CI - (c)Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. FAU - Parizad, Razieh AU - Parizad R AD - Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz 51656/87386, Iran. FAU - Hatwal, Juniali AU - Hatwal J AD - Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India. FAU - Brar, Ajit Singh AU - Brar AS AD - Department of Internal Medicine, Michigan State University at Hurley Medical Center, Flint, MI 48503, United States. FAU - Alizadeh, Leila AU - Alizadeh L AD - Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz 5166/15731, Iran. FAU - Goyal, Manjeet Kumar AU - Goyal MK AD - Department of Internal Medicine, Cleveland Clinic Akron General Hospital, Akron, OH 110029, United States. FAU - Batta, Akash AU - Batta A AD - Department of Cardiology, Dayanand Medical College and Hospital, Ludhiana 141001, Punjab, India. akashbatta02@gmail.com. FAU - Mohan, Bishav AU - Mohan B AD - Department of Cardiology, Dayanand Medical College and Hospital, Ludhiana 141001, Punjab, India. LA - eng PT - Journal Article DEP - 20260309 PL - United States TA - World J Clin Pediatr JT - World journal of clinical pediatrics JID - 101627548 PMC - PMC13010889 OTO - NOTNLM OT - Childhood obesity OT - Insulin resistance OT - Metabolic dysfunction-associated steatotic liver disease OT - Metabolic syndrome OT - Non-alcoholic fatty liver disease OT - Pediatric OT - Type 2 diabetes mellitus COIS- Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript. EDAT- 2026/03/26 07:09 MHDA- 2026/03/26 07:10 PMCR- 2026/03/09 CRDT- 2026/03/26 05:00 PHST- 2025/06/23 00:00 [received] PHST- 2025/07/24 00:00 [revised] PHST- 2025/10/28 00:00 [accepted] PHST- 2026/03/26 07:10 [medline] PHST- 2026/03/26 07:09 [pubmed] PHST- 2026/03/26 05:00 [entrez] PHST- 2026/03/09 00:00 [pmc-release] AID - 10.5409/wjcp.v15.i1.111030 [doi] PST - epublish SO - World J Clin Pediatr. 2026 Mar 9;15(1):111030. doi: 10.5409/wjcp.v15.i1.111030. eCollection 2026 Mar 9. PMID- 41883353 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260326 LR - 20260813 IS - 2768-2765 (Electronic) IS - 2768-2765 (Linking) VI - 15 DP - 2026 May TI - Elbow Soft Tissue Apex as a Marker for the Anterior Humeral Line: An Anatomic Landmark for Pinning of Pediatric Supracondylar Humerus Fractures. PG - 100346 LID - 10.1016/j.jposna.2026.100346 [doi] LID - 100346 AB - BACKGROUND: Three-dimensional awareness of humeral anatomy is paramount to the successful percutaneous pinning of pediatric supracondylar humerus fractures. Technical tips and anatomic landmarks can help residents develop basic surgical skills and understand the humerus's position within the soft tissue envelope. For patients with an extension-type supracondylar humerus fracture, the soft tissue apex of the elbow in full flexion ( approximately 130 degrees ) serves as an anatomic correlate for the anterior humeral line. This novel anatomic landmark can assist trainees in visualizing the humeral shaft, estimating the pin placement angle, and achieving adequate fracture fixation. METHODS: A single-institution electronic medical record was reviewed for supracondylar humerus fracture fixation within the past two years. Fluoroscopic series were reviewed for reduction laterals. Injury films were reviewed for humeral measurements and fluoroscopic calibration. A line along the axis of the anterior humeral cortex was drawn through the soft tissue shadow on the reduction lateral and the distance from the line's intersection through the skin and the soft tissue apex was measured. RESULTS: Thirty-two patients were studied, comprising 17 males and 15 females, with a mean age of 6.6 years (SD +/- 1.69 years). Fractures were classified using the Gartland classification, with 16 classified as type II and 16 as type III. The average lateral cortical width measured 12.8 mm (SD +/- 1.79 mm), while the intramedullary width averaged 7.4 mm (SD +/- 1.23 mm). The mean distance between the soft tissue apex and the anterior humeral cortex was 0.85 mm (SD +/- 1.09 mm). CONCLUSIONS: The soft tissue apex of the elbow is a reliable landmark for the anterior humeral cortex, providing trainees with an intuitive and easily visualized reference for guiding pin placement. Utilization of this technique can enhance intraoperative efficiency and precision, making it a valuable tool to have in surgeon's armamentarium. KEY CONCEPTS: (1)While supracondylar humerus fractures are amongst the most common operative pediatric injuries, orthopaedic residents perform an average of only 19 of these cases during their training.(2)Identification of reproducible landmarks enhances outcomes, improves autonomy, and reduces fluoroscopy utilization, particularly for residents and early-career surgeons.(3)The soft tissue apex of the elbow serves as a reliable landmark for the anterior humeral cortex, regardless of patient age or BMI. LEVEL OF EVIDENCE: IV - Case series with no comparison group. CI - (c) 2026 The Authors. FAU - Lobato, Evan AU - Lobato E AD - Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA. FAU - Sain, Jared AU - Sain J AD - Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA. FAU - Resnikoff, Henry AU - Resnikoff H AD - Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA. FAU - Hawes, Joseph AU - Hawes J AD - Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA. FAU - Borole, Aryan AU - Borole A AD - Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA. FAU - Afolabi-Brown, Kikelola AU - Afolabi-Brown K AD - Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA. FAU - Adolfsen, Stephen AU - Adolfsen S AD - Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA. LA - eng PT - Journal Article DEP - 20260223 PL - United States TA - J Pediatr Soc North Am JT - Journal of the Pediatric Orthopaedic Society of North America JID - 101776896 PMC - PMC13010940 OTO - NOTNLM OT - Adolescent OT - External anatomic lankmarks OT - Fluoroscopic OT - Percutaneous pinning OT - Supracondylar humerus fracture COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/03/26 07:09 MHDA- 2026/03/26 07:10 PMCR- 2026/02/23 CRDT- 2026/03/26 04:54 PHST- 2026/01/06 00:00 [received] PHST- 2026/02/15 00:00 [revised] PHST- 2026/02/17 00:00 [accepted] PHST- 2026/03/26 07:10 [medline] PHST- 2026/03/26 07:09 [pubmed] PHST- 2026/03/26 04:54 [entrez] PHST- 2026/02/23 00:00 [pmc-release] AID - S2768-2765(26)00025-8 [pii] AID - 100346 [pii] AID - 10.1016/j.jposna.2026.100346 [doi] PST - epublish SO - J Pediatr Soc North Am. 2026 Feb 23;15:100346. doi: 10.1016/j.jposna.2026.100346. eCollection 2026 May. PMID- 41883328 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2026 Mar 26 TI - The role of household food insecurity in malnutrition among Indonesian children under 5 years of age: a systematic review and meta-analysis (2015-2025). PG - e86 LID - 10.1017/S1368980026102365 [doi] LID - e86 AB - OBJECTIVE: To synthesise and quantify the association between household food insecurity (HFI) and various forms of malnutrition that include stunting, wasting, underweight, overnutrition and anaemia among Indonesian children under 5 years of age. DESIGN: A systematic review and meta-analysis was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. The study included literature search, screening, data extraction, quality assessment using Joanna Briggs Institute (JBI) tools and meta-analysis using Review Manager 5.4. SETTING: Studies conducted in Indonesia, covering urban, rural and mixed settings across multiple provinces. PARTICIPANTS: Children under 5 years of age residing in Indonesia, from households assessed for food insecurity using validated tools. RESULTS: A total of thirty-two studies met the inclusion criteria, of which twenty-six were eligible for meta-analysis. HFI was significantly associated with higher odds of stunting (case-control: OR = 4.66; 95 % CI: 3.39, 6.40; P < 0.001; cross-sectional: OR = 4.61; 95 % CI: 4.17, 5.11; P < 0.001), wasting (OR = 1.92; 95 % CI: 1.60, 2.32; P < 0.001), underweight (OR = 5.26; 95 % CI: 2.12, 13.04; P < 0.001) and overnutrition (OR = 1.66; 95 % CI: 1.49, 1.85; P < 0.001). Children in food-secure households had significantly lower odds of anaemia (OR = 0.41; 95 % CI: 0.30, 0.58; P < 0.001). CONCLUSIONS: HFI is strongly associated with multiple forms of malnutrition among Indonesian children under 5 years of age. These findings highlight the urgent need for integrated, nutrition-sensitive strategies that address food security to improve child health and reduce malnutrition in Indonesia. FAU - Sutrisno, Rahayu AU - Sutrisno R AUID- ORCID: 0000-0002-8867-0222 AD - Master of Nutrition Science Study Program, Faculty of Health Sciences, Universitas Brawijaya, Indonesia. FAU - Fatmawati, Irka Dwi AU - Fatmawati ID AD - Master of Nutrition Science Study Program, Faculty of Health Sciences, Universitas Brawijaya, Indonesia. FAU - Laksono, Agung Dwi AU - Laksono AD AD - Research Center of Public Health and Nutrition, National Research and Innovation Agency Republic of Indonesia, Indonesia. FAU - Rahmawati, Widya AU - Rahmawati W AUID- ORCID: 0000-0003-4139-5064 AD - Nutrition Department, Faculty of Health Sciences, https://ror.org/01wk3d929Universitas Brawijaya, Indonesia. FAU - Wirawan, Nia Novita AU - Wirawan NN AD - Nutrition Department, Faculty of Health Sciences, https://ror.org/01wk3d929Universitas Brawijaya, Indonesia. FAU - Handayani, Dian AU - Handayani D AUID- ORCID: 0000-0001-9018-0233 AD - Nutrition Department, Faculty of Health Sciences, https://ror.org/01wk3d929Universitas Brawijaya, Indonesia. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260326 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Indonesia/epidemiology MH - *Food Insecurity MH - Child, Preschool MH - *Child Nutrition Disorders/epidemiology MH - *Family Characteristics MH - Infant MH - *Malnutrition/epidemiology MH - Thinness/epidemiology MH - Growth Disorders/epidemiology MH - Wasting Syndrome/epidemiology MH - Anemia/epidemiology MH - Female MH - Male PMC - PMC13112310 OTO - NOTNLM OT - Child malnutrition OT - Household food insecurity OT - Indonesia OT - Meta-analysis OT - Systematic review COIS- There are no conflicts of interest. EDAT- 2026/03/26 07:09 MHDA- 2026/04/15 06:29 PMCR- 2026/03/26 CRDT- 2026/03/26 04:53 PHST- 2026/04/15 06:29 [medline] PHST- 2026/03/26 07:09 [pubmed] PHST- 2026/03/26 04:53 [entrez] PHST- 2026/03/26 00:00 [pmc-release] AID - S1368980026102365 [pii] AID - 10.1017/S1368980026102365 [doi] PST - epublish SO - Public Health Nutr. 2026 Mar 26;29(1):e86. doi: 10.1017/S1368980026102365. PMID- 41882922 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260827 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 1 DP - 2026 Jan TI - Maternal and Child Diet Quality Trajectories and Their Determinants. PG - e70171 LID - 10.1111/mcn.70171 [doi] LID - e70171 AB - This study examined the trajectories of maternal and child diet quality in the first 5 years postpartum and their determinants. Data of 330 mother-child pairs from the Melbourne Infant Feeding, Activity and Nutrition Trial Programme were used. Maternal and child dietary data were collected using validated food frequency questionnaires, with maternal data collected when children were aged 4, 18, 42 and 60 months and child data at ages 18, 42 and 60 months. Maternal and child diet quality were calculated using the 2013 Dietary Guideline Index and the Dietary Guideline Index for Children and Adolescents, respectively. Group-based multi-trajectory modelling was conducted to examine multi-trajectory groups following distinct joint trajectories of maternal and child diet quality. Determinants of multi-trajectory groups were evaluated using logistic regression. Three distinct multi-trajectory groups of low (10.9%), moderate (57.6%) and high (31.5%) maternal and child diet quality were identified; high diet quality represented better adherence to dietary guidelines. Higher maternal prepregnancy BMI was associated with a higher relative risk of following the low (RRR 1.11; 95% CI: 1.02, 1.21) versus the high maternal and child diet quality multi-trajectory group. Breastfeeding for >/= 6 months was associated with a lower relative risk (RRR 0.37; 95% CI: 0.15, 0.91) of following the low versus the high maternal and child diet quality multi-trajectory group. The longitudinal association between maternal and child diet quality suggests that interventions to improve maternal diet quality will likely benefit child diet quality. Interventions should target women with a high prepregnancy BMI and promote breastfeeding. CI - (c) 2026 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Sexton-Dhamu, Meaghan J AU - Sexton-Dhamu MJ AUID- ORCID: 0000-0003-2752-8350 AD - Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia. FAU - Livingstone, Katherine M AU - Livingstone KM AD - Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia. FAU - Szymlek-Gay, Ewa A AU - Szymlek-Gay EA AD - Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia. FAU - Campbell, Karen J AU - Campbell KJ AD - Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia. FAU - Zheng, Miaobing AU - Zheng M AUID- ORCID: 0000-0002-4151-3502 AD - Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia. AD - School of Health Sciences, Faculty of Health & Medicine, University of New South Wales, Sydney, New South Wales, Australia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - Female MH - *Diet MH - Infant MH - Breast Feeding MH - *Maternal Nutritional Physiological Phenomena MH - Child, Preschool MH - Adult MH - Mothers MH - Male MH - Nutrition Policy MH - Body Mass Index MH - *Child Nutritional Physiological Phenomena MH - Infant Nutritional Physiological Phenomena PMC - PMC13344142 OTO - NOTNLM OT - child OT - diet quality OT - maternal OT - trajectories COIS- The authors declare no conflicts of interest. EDAT- 2026/03/26 07:09 MHDA- 2026/03/26 07:10 PMCR- 2026/03/25 CRDT- 2026/03/26 01:03 PHST- 2026/01/29 00:00 [revised] PHST- 2025/02/25 00:00 [received] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/03/26 07:10 [medline] PHST- 2026/03/26 07:09 [pubmed] PHST- 2026/03/26 01:03 [entrez] PHST- 2026/03/25 00:00 [pmc-release] AID - MCN70171 [pii] AID - 10.1111/mcn.70171 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Jan;22(1):e70171. doi: 10.1111/mcn.70171. PMID- 41882615 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Mar 26 TI - Development and validation of a tool to assess mothers' knowledge, perception, and practice of child growth monitoring. LID - 10.1186/s12884-026-08972-y [doi] LID - 486 AB - BACKGROUND: Child growth monitoring (CGM) is essential for the early detection and prevention of malnutrition and growth abnormalities. Despite its importance, there is a lack of validated instruments to assess mothers' knowledge, perceptions, and practices related to CGM. This study aimed to develop and validate a comprehensive questionnaire to assess these domains among mothers of children under five years of age. METHODS: The study was conducted in two stages. First, a theory-driven questionnaire was developed based on an extensive literature review, global and national guidelines, and expert consultation. Second, the questionnaire's psychometric properties were evaluated using data from a cross-sectional survey of 436 mothers. An expert panel assessed content validity, internal consistency was examined using Cronbach's alpha, and construct validity was evaluated using confirmatory factor analysis (CFA). RESULTS: The final questionnaire comprised 67 items across three domains: knowledge (27 items), perception (14 items), and practice (11 items). The instrument demonstrated good overall internal consistency (Cronbach's alpha = 0.82), with strong reliability across main domains (alpha = 0.81-0.92). CFA supported the hypothesized three-domain structure, with good model fit indices for the full measurement model (CMIN/DF = 1.62; CFI = 0.93; TLI = 0.93; RMSEA = 0.038). CONCLUSION: This study presents a valid and reliable questionnaire for assessing mothers' knowledge, perceptions, and practices regarding CGM. The tool can support research, inform maternal education strategies, and guide public health interventions to improve early childhood growth outcomes. FAU - Masuadi, Emad AU - Masuadi E AUID- ORCID: 0000-0002-7360-7693 AD - Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, 15551, United Arab Emirates. emasuadi@uaeu.ac.ae. AD - Epidemiology and Biostatistical Consulting Unit, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, 15551, United Arab Emirates. emasuadi@uaeu.ac.ae. FAU - Cheikh Ismail, Leila AU - Cheikh Ismail L AUID- ORCID: 0000-0003-3048-7481 AD - Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates. AD - Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, OX1 2JD, UK. FAU - Saleh, Sheima T AU - Saleh ST AUID- ORCID: 0000-0003-2871-1341 AD - Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates. FAU - Hashim, Mona AU - Hashim M AUID- ORCID: 0000-0002-3494-4718 AD - Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates. FAU - Hasan, Haydar AU - Hasan H AUID- ORCID: 0000-0001-5580-1911 AD - Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates. FAU - Mohamad, Maysm N AU - Mohamad MN AUID- ORCID: 0000-0002-6396-6625 AD - Department of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, 15551, United Arab Emirates. FAU - Stojanovska, Lily AU - Stojanovska L AUID- ORCID: 0000-0001-7186-4461 AD - Institute for Health and Sport, Victoria University, Melbourne, VIC, 3011, Australia. FAU - Elhadi, Yasir Ahmed Mohammed AU - Elhadi YAM AUID- ORCID: 0000-0003-3649-0374 AD - Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, 15551, United Arab Emirates. FAU - Al Dhaheri, Ayesha AU - Al Dhaheri A AUID- ORCID: 0000-0002-7634-3531 AD - Department of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, 15551, United Arab Emirates. LA - eng PT - Journal Article PT - Validation Study DEP - 20260326 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - *Health Knowledge, Attitudes, Practice MH - Female MH - *Mothers/psychology MH - Surveys and Questionnaires/standards MH - Cross-Sectional Studies MH - *Child Development MH - Psychometrics MH - Reproducibility of Results MH - Adult MH - Child, Preschool MH - Infant MH - Factor Analysis, Statistical MH - Young Adult PMC - PMC13141268 OTO - NOTNLM OT - Child Growth Monitoring OT - Early Childhood Development OT - Maternal Health Education OT - Maternal Perceptions OT - Parental Health Literacy COIS- Declarations. Ethics approval and consent to participate: This study adhered to the guidelines outlined in the Declaration of Helsinki. Ethical approval was granted by the Research Human Ethics Committee at the University of Sharjah (Ref: REC-23-02-09-01), the UAE Ministry of Health and Prevention (Ref: MOHAP/REC/2022/21-2023-PG-M), and the University Hospital of Sharjah (Ref: UHS-HERC-132-21052023). Additionally, internal approval was secured from the management of each participating hospital. Informed written consent was obtained from all participants before the study commenced. The data collection process involved systematically recording participant responses online through a digital platform. These responses were then exported into an Excel spreadsheet for comprehensive analysis. The collected data were securely stored on a password-protected research computer to ensure confidentiality and maintain data integrity throughout the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/26 07:09 MHDA- 2026/06/28 00:38 PMCR- 2026/03/26 CRDT- 2026/03/26 00:48 PHST- 2024/09/30 00:00 [received] PHST- 2026/03/18 00:00 [accepted] PHST- 2026/06/28 00:38 [medline] PHST- 2026/03/26 07:09 [pubmed] PHST- 2026/03/26 00:48 [entrez] PHST- 2026/03/26 00:00 [pmc-release] AID - 10.1186/s12884-026-08972-y [pii] AID - 8972 [pii] AID - 10.1186/s12884-026-08972-y [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Mar 26;26(1):486. doi: 10.1186/s12884-026-08972-y. PMID- 41882547 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2731-4553 (Electronic) IS - 2731-4553 (Linking) VI - 27 IP - 1 DP - 2026 Mar 25 TI - Nutritional assessment and lifestyle counseling for pregnant women in primary health care units in Mexico: implementation evaluation. LID - 10.1186/s12875-026-03257-x [doi] LID - 174 AB - BACKGROUND: Maternal malnutrition, expressed as both undernutrition and excessive gestational weight gain, remains a major public health challenge in Mexico. Primary health care units are the main platform for the provision of evidence-based nutritional interventions, including nutritional status assessment and counseling on healthy eating and physical activity. However, there is limited knowledge about their systematic implementation in routine prenatal care. This study aimed to evaluate the implementation of these interventions in primary health care units in Morelos, Mexico, focusing on key implementation outcomes. METHODS: A mixed-methods sequential design was applied. Quantitative data were collected through structured and validated questionnaires with health personnel (n = 59) to assess acceptability, adoption, and feasibility; review of physical records of prenatal consultations (n = 1,067) to estimate coverage; and non-participant observation of consultations (n = 368) to measure fidelity. Implementation outcomes were assessed using validated instruments and compliance checklists. Descriptive statistics and multiple linear regression analyses were performed. Qualitative data were obtained through in-depth interviews with health personnel and pregnant women (n = 24) from a subsample of 12 units between April and May 2025, analyzed thematically to explore perceptions, facilitators, and barriers. RESULTS: Health personnel expressed high acceptability and willingness to adopt nutritional interventions, although only 27% had received specific training in nutrition care. Coverage of weight measurement was nearly universal, but hemoglobin testing (24.6%) and nutritional status assessment (8.2%) had very low performance, particularly in rural units. Fidelity varied across interventions: nutritional assessment achieved the highest compliance (47.8%), while counseling on healthy eating (19.1%) and physical activity (8.6%) were rarely implemented. Structural barriers included limited consultation time, lack of educational materials, and excessive workload. Pregnant women valued counseling but reported economic and cultural challenges to adopting recommendations. CONCLUSIONS: Although health personnel show strong acceptance of nutritional interventions, their implementation in primary care is hindered by systemic barriers. Low coverage and fidelity, especially in rural contexts, represent missed opportunities to improve maternal and child health. Greater training, resources, and integration of structured counseling into prenatal care are needed to strengthen equity and effectiveness of services. FAU - Pacheco-Miranda, Selene AU - Pacheco-Miranda S AD - Nutrition and Health Research Center, National Institute of Public Health, Cuernavaca, Mexico. AD - Vitamin Angels Alliance, Mexico City, Mexico. FAU - Cruz-Casarrubias, Carlos AU - Cruz-Casarrubias C AD - Nutrition and Health Research Center, National Institute of Public Health, Cuernavaca, Mexico. FAU - Paola-Arequipa Toapanta, Renata AU - Paola-Arequipa Toapanta R AD - School of Public Health, National Institute of Public Health of Mexico, Cuernavaca, Mexico. FAU - Perez-Escamilla, Rafael AU - Perez-Escamilla R AD - Department of Social and Behavioral Sciences, Yale School of Public Health, New Haven, CT, USA. FAU - Reyes-Morales, Hortensia AU - Reyes-Morales H AD - Health Systems Research Center, National Institute of Public Health, Cuernavaca, Mexico. FAU - Denova-Gutierrez, Edgar AU - Denova-Gutierrez E AD - Department of Nutrition, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico City, Mexico. FAU - Hernandez-Barrera, Lucia AU - Hernandez-Barrera L AD - Nutrition and Health Research Center, National Institute of Public Health, Cuernavaca, Mexico. FAU - Rios-Espinosa, Enrique AU - Rios-Espinosa E AD - Vitamin Angels Alliance, Mexico City, Mexico. FAU - Bonvecchio-Arenas, Anabelle AU - Bonvecchio-Arenas A AD - School of Public Health, National Institute of Public Health of Mexico, Cuernavaca, Mexico. bonvecchio@insp.mx. LA - eng PT - Journal Article DEP - 20260325 PL - England TA - BMC Prim Care JT - BMC primary care JID - 9918300889006676 SB - IM MH - Humans MH - Female MH - Mexico MH - Pregnancy MH - *Primary Health Care MH - *Counseling/methods MH - Adult MH - *Prenatal Care/methods MH - *Nutrition Assessment MH - Exercise MH - *Life Style MH - Young Adult MH - Diet, Healthy MH - *Pregnancy Complications/prevention & control MH - Malnutrition/prevention & control PMC - PMC13137730 OTO - NOTNLM OT - Implementation science OT - Maternal nutrition OT - Prenatal care OT - Primary health care COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Ethics, Research, and Biosafety Committees of the National Institute of Public Health of Mexico (November 2023, Project CI 14179), and authorized by the State Coordination of IMSS-BIENESTAR Health Services in Morelos (July 2024, Reference No. JSAS-095/2024). This research was conducted in accordance with the principles outlined in the Declaration of Helsinki. All participants provided written informed consent prior to enrollment and the initiation of data collection activities. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/26 07:09 MHDA- 2026/06/28 00:38 PMCR- 2026/03/25 CRDT- 2026/03/26 00:44 PHST- 2025/10/21 00:00 [received] PHST- 2026/03/03 00:00 [accepted] PHST- 2026/06/28 00:38 [medline] PHST- 2026/03/26 07:09 [pubmed] PHST- 2026/03/26 00:44 [entrez] PHST- 2026/03/25 00:00 [pmc-release] AID - 10.1186/s12875-026-03257-x [pii] AID - 3257 [pii] AID - 10.1186/s12875-026-03257-x [doi] PST - epublish SO - BMC Prim Care. 2026 Mar 25;27(1):174. doi: 10.1186/s12875-026-03257-x. PMID- 41881109 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260718 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 222 DP - 2026 Jul 1 TI - School children's food literacy and dietary behaviors according to maternal food literacy in Korea. PG - 108543 LID - S0195-6663(26)00105-4 [pii] LID - 10.1016/j.appet.2026.108543 [doi] AB - BACKGROUND AND OBJECTIVE: A caregiver's food literacy (FL) is a key factor in their children's FL and healthy dietary behaviors. However, the research on the relationship between FL and its outcomes is limited, especially among the Korean population. Thus, this cross-sectional study was conducted to examine the relationship between maternal FL and primary school children's FL and dietary behaviors in Korea. METHODS: A total of 800 participants, including mothers and their children simultaneously, were enrolled in an online survey conducted in June 2021. This included 400 mothers who were the primary caregivers for their children in the household and their 400 children, who were in the 4th to 6th grades of elementary school. The subjects responded to the FL questionnaire as well as questions about their general characteristics, dietary habits. The food literacy questionnaire, which was validated, comprised 25 questions including five factors (production, selection, preparation and cooking, intake, and disposal) for mothers and 19 questions including five factors (production, distribution, selection, preparation and cooking, and intake) for children. RESULTS: There was a positive association between the mother's FL scores and the child's FL scores (r = 0.4586, p < 0.0001). The participants were categorized into quartile groups according to FL scores, maternal FL was significantly associated with child's skipping breakfast [OR (95% CI) = 0.29 (0.16-0.53)], child's skipping lunch [OR (95% CI) = 0.32 (0.16-0.66)], and child's eating-out [OR (95% CI) = 0.32 (0.15-0.68)]. CONCLUSIONS: This study found that maternal FL may positively affect children's FL, as well as their dietary habits. These findings suggest that improving maternal FL may have the potential to promote a healthier diet for their children, although additional research is needed. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Kim, Eun-Kyung AU - Kim EK AD - National Institute of Crop and Food Science, Rural Development Administration, Wanju, South Korea. FAU - Park, Young Hee AU - Park YH AD - National Institute of Crop and Food Science, Rural Development Administration, Wanju, South Korea. FAU - Kwon, Yong-Seok AU - Kwon YS AD - National Institute of Crop and Food Science, Rural Development Administration, Wanju, South Korea. FAU - Kim, Sena AU - Kim S AD - National Institute of Crop and Food Science, Rural Development Administration, Wanju, South Korea. FAU - Lee, Jin-Young AU - Lee JY AD - National Institute of Crop and Food Science, Rural Development Administration, Wanju, South Korea. Electronic address: cherry78@korea.kr. FAU - Shin, Min-Jeong AU - Shin MJ AD - Interdisciplinary Program in Precision Public Health, Department of Public Health Sciences, Graduate School of Korea University, Seoul, South Korea; School of Biosystems and Biomedical Sciences, College of Health Science, Korea University, Seoul, South Korea. LA - eng PT - Journal Article DEP - 20260323 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Child MH - Republic of Korea MH - *Mothers/psychology/statistics & numerical data MH - *Feeding Behavior/psychology MH - Surveys and Questionnaires MH - Male MH - *Health Literacy/statistics & numerical data MH - Adult MH - Diet MH - Diet, Healthy/psychology OTO - NOTNLM OT - Dietary behaviors OT - Eating-out OT - Elementary school children OT - Food literacy OT - Skipping meal COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/03/26 01:03 MHDA- 2026/05/08 00:32 CRDT- 2026/03/25 20:11 PHST- 2025/02/24 00:00 [received] PHST- 2025/11/27 00:00 [revised] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/05/08 00:32 [medline] PHST- 2026/03/26 01:03 [pubmed] PHST- 2026/03/25 20:11 [entrez] AID - S0195-6663(26)00105-4 [pii] AID - 10.1016/j.appet.2026.108543 [doi] PST - ppublish SO - Appetite. 2026 Jul 1;222:108543. doi: 10.1016/j.appet.2026.108543. Epub 2026 Mar 23. PMID- 41880604 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260826 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 Mar 25 TI - Increasing Physical Activity in Educational Settings Using Mixed Reality Technology: Iterative Formative Study. PG - e83556 LID - 10.2196/83556 [doi] LID - e83556 AB - BACKGROUND: As physical education classes are lost to budget cuts and recess is canceled to meet standardized testing goals, the modern school day has become dominated by sedentary digital activities. To reverse this trend, current interventions have focused on reducing screen time. However, instead of fighting this digital invasion, this study examined the use of technology, specifically mixed reality, to turn screen time from sedentary into active time, promoting physical activity in a classroom setting. OBJECTIVE: The primary aim of this study was to iteratively develop and test a mixed reality prototype that promotes physical activity (eg, jumping, squatting, and punching) during a digital classroom activity. The primary outcomes were the percentage of active time during the activity, a breakdown of the intensity of that active time, and an evaluation of the prototype's usability. METHODS: Between November 2023 and April 2025, a multidisciplinary research team developed a prototype and evaluated it during 2 rounds of pilot-testing. Participants were aged 10 to 15 years and attended local middle schools. Physical activity was assessed using a medical-grade, hip-worn accelerometer (ActiGraph wGT3X-BT). Acceptability was assessed using a validated questionnaire (the System Usability Scale) that has a maximum score of 100. To collect feedback for prototype improvements, semistructured interviews were conducted after each round of pilot-testing. RESULTS: In the first round of pilot-testing, students (n=22) were active for 46.0% (6.9, SD 2.7 minutes) of the headset session, which lasted 15 (SD 0) minutes. After improving the prototype using feedback from the first round, students in the second round (n=10) were active for 5.8 (SD 3.1) minutes (62.4%) of the web-based assignment, which lasted 9.3 (SD 2.41) minutes, while still reporting "good" acceptability scores (mean 73.8, SD 17.2). There were no significant differences in acceptability ratings between the 2 pilot-testing rounds (P=.16), nor were there differences between boys and girls in round 1 (P=.79) or round 2 (P=.61). CONCLUSIONS: The results of this iterative study indicate that mixed reality can be used to elicit physical activity in a classroom setting, at least for short assignments. However, further research is needed to determine longer-term use and effectiveness. CI - (c) Katherine E Spring, Calvin W Feldt, Matthew Parker Posey, Phillip Nauta, Senlin Chen, David C Shepherd, Amanda E Staiano. Originally published in JMIR Formative Research (https://formative.jmir.org). FAU - Spring, Katherine E AU - Spring KE AUID- ORCID: 0000-0002-5606-5191 AD - Pennington Biomedical Research Center, 6400 Perkins Rd., Baton Rouge, LA, 70808, United States, 1 2257632729. FAU - Feldt, Calvin W AU - Feldt CW AUID- ORCID: 0009-0009-1185-5833 AD - Division of Computer Science and Engineering, Louisiana State University, Baton Rouge, LA, United States. FAU - Posey, Matthew Parker AU - Posey MP AUID- ORCID: 0009-0004-2290-5860 AD - Division of Computer Science and Engineering, Louisiana State University, Baton Rouge, LA, United States. FAU - Nauta, Phillip AU - Nauta P AUID- ORCID: 0000-0002-9361-1470 AD - Pennington Biomedical Research Center, 6400 Perkins Rd., Baton Rouge, LA, 70808, United States, 1 2257632729. FAU - Chen, Senlin AU - Chen S AUID- ORCID: 0000-0003-0945-4271 AD - School of Kinesiology, Louisiana State University, Baton Rouge, LA, United States. FAU - Shepherd, David C AU - Shepherd DC AUID- ORCID: 0000-0003-2017-7842 AD - Division of Computer Science and Engineering, Louisiana State University, Baton Rouge, LA, United States. FAU - Staiano, Amanda E AU - Staiano AE AUID- ORCID: 0000-0001-7846-046X AD - Pennington Biomedical Research Center, 6400 Perkins Rd., Baton Rouge, LA, 70808, United States, 1 2257632729. LA - eng GR - T32 DK064584/DK/NIDDK NIH HHS/United States GR - U54 GM104940/GM/NIGMS NIH HHS/United States GR - P30DK072476/NIH National Institute of Diabetes and Digestive and Kidney Diseases/ PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20260325 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - *Exercise/psychology MH - Child MH - Adolescent MH - Female MH - Male MH - *Physical Education and Training/methods MH - Schools/organization & administration MH - Surveys and Questionnaires MH - Accelerometry/instrumentation/methods PMC - PMC13016437 OTO - NOTNLM OT - active learning technologies OT - digital learning tools OT - middle school OT - mixed reality OT - school-based physical activity COIS- Conflicts of Interest: None declared. EDAT- 2026/03/25 19:36 MHDA- 2026/03/25 19:37 PMCR- 2026/03/25 CRDT- 2026/03/25 15:43 PHST- 2025/09/04 00:00 [received] PHST- 2026/02/23 00:00 [accepted] PHST- 2026/03/25 19:37 [medline] PHST- 2026/03/25 19:36 [pubmed] PHST- 2026/03/25 15:43 [entrez] PHST- 2026/03/25 00:00 [pmc-release] AID - v10i1e83556 [pii] AID - 83556 [pii] AID - 10.2196/83556 [doi] PST - epublish SO - JMIR Form Res. 2026 Mar 25;10:e83556. doi: 10.2196/83556. PMID- 41880458 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260713 IS - 1518-8787 (Electronic) IS - 0034-8910 (Linking) VI - 60 DP - 2026 TI - Profile of food and beverage street vendors around private schools in Brazil. PG - e14 LID - S0034-89102026000100613 [pii] LID - 10.11606/s1518-8787.2026060007205 [doi] AB - OBJECTIVE: To describe the socioeconomic profile and activity of street vendors, as well as the profile of food sales, according to industrial processing, in the vicinity of private schools in Brazilian state capitals. METHODS: Cross-sectional study with street vendors in the immediate vicinity of a national probability sample of Brazilian private schools. Elementary and/or high schools participating in the Food Marketing in Brazilian Schools Study were included. A previously validated questionnaire was applied to characterize workers, infrastructure and food availability. Food was classified according to the NOVA system. Comparisons between macro-regions (North, Northeast, Central-West, Southeast, and South) and sizes of point of sale (smallest: 1-3 items; intermediate: 4-13 items; largest: >/= 14 items) were evaluated using the Kruskal-Wallis test. RESULTS: The informal food and beverage trade in the immediate vicinity of 2,180 private schools was mapped, totaling 699 street vendors. There was a predominance of men (57.8%), black people (68.8%), those with completed secondary education (35.8%), and those who worked informally (91.4%), in carts and stalls, due to a lack of opportunity in the formal market (52.5%). The median number of ultra-processed items was about twice that of in natura, minimally processed, or processed foods and preparations based on them (2.17; 95%CI 1.90-2.45). Larger outlets concentrated more ultra-processed foods in all regions, except in the Northeast, where this predominance already occurred in intermediate-sized outlets (3.32; 95%CI 2.88-3.75). The lowest ratio of ultra-processed foods was observed in the South (0.21; 95%CI 0.05-0.37) and the highest in the Northeast (3.32; 95%CI 2.88-3.75). CONCLUSION: Street vending around Brazilian private schools reflects structural inequalities and expands commercially in the supply of ultra-processed foods to children and adolescents. We recommend its inclusion as an inseparable component in the evaluation of the school food environment, to support policies that reconcile income generation and the promotion of healthy eating. FAU - Clark, Sabrina Gomes Ferreira AU - Clark SGF AUID- ORCID: 0000-0002-9037-4553 AD - Universidade Federal de Pernambuco. Centro de Ciencias da Saude. Servico-Escola de Nutricao Emilia Aureliano. Recife, PE, Brasil. FAU - Mendes, Larissa Loures AU - Mendes LL AUID- ORCID: 0000-0003-0776-6845 AD - Universidade Federal de Minas Gerais. Escola de Enfermagem. Departamento de Nutricao. Belo Horizonte, MG, Brasil. FAU - Oliveira, Juliana Souza AU - Oliveira JS AUID- ORCID: 0000-0003-1449-8930 AD - Universidade Federal de Pernambuco. Centro Academico de Vitoria. Departamento de Nutricao. Vitoria de Santo Antao, PE, Brasil. FAU - Borges, Luiza Delazari AU - Borges LD AUID- ORCID: 0000-0002-9399-255X AD - Universidade Federal de Minas Gerais. Escola de Enfermagem. Departamento de Nutricao. Belo Horizonte, MG, Brasil. FAU - Tavares, Leticia Ferreira AU - Tavares LF AUID- ORCID: 0000-0001-5205-2994 AD - Universidade Federal do Rio de Janeiro. Instituto de Nutricao Josue de Castro. Rio de Janeiro, RJ, Brasil. FAU - Castro Junior, Paulo Cesar Pereira de AU - Castro Junior PCP AUID- ORCID: 0000-0002-6629-9610 AD - Universidade Federal do Rio de Janeiro. Instituto de Nutricao Josue de Castro. Rio de Janeiro, RJ, Brasil. FAU - Cardoso, Leticia de Oliveira AU - Cardoso LO AUID- ORCID: 0000-0003-1312-1808 AD - Fundacao Oswaldo Cruz. Escola Nacional de Saude Publica Sergio Arouca. Rio de Janeiro, RJ, Brasil. FAU - Canuto, Raquel AU - Canuto R AUID- ORCID: 0000-0002-4042-1913 AD - Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Departamento de Nutricao. Porto Alegre, RS, Brasil. LA - eng LA - por PT - Journal Article DEP - 20260320 PL - Brazil TA - Rev Saude Publica JT - Revista de saude publica JID - 0135043 SB - IM MH - Humans MH - Brazil MH - Cross-Sectional Studies MH - *Schools/statistics & numerical data MH - Socioeconomic Factors MH - Male MH - Female MH - Private Sector/statistics & numerical data MH - Street Food MH - *Commerce/statistics & numerical data MH - *Beverages/supply & distribution MH - Surveys and Questionnaires EDAT- 2026/03/25 19:36 MHDA- 2026/03/25 19:37 CRDT- 2026/03/25 13:53 PHST- 2025/07/18 00:00 [received] PHST- 2026/01/11 00:00 [accepted] PHST- 2026/03/25 19:37 [medline] PHST- 2026/03/25 19:36 [pubmed] PHST- 2026/03/25 13:53 [entrez] AID - S0034-89102026000100613 [pii] AID - 10.11606/s1518-8787.2026060007205 [doi] PST - epublish SO - Rev Saude Publica. 2026 Mar 20;60:e14. doi: 10.11606/s1518-8787.2026060007205. eCollection 2026. PMID- 41878794 OWN - NLM STAT- MEDLINE DCOM- 20260702 LR - 20260920 IS - 1098-108X (Electronic) IS - 0276-3478 (Print) IS - 0276-3478 (Linking) VI - 59 IP - 7 DP - 2026 Jul TI - Eating Disorder Screening in Adults With Williams Syndrome: A Preliminary Report. PG - 1543-1551 LID - 10.1002/eat.70070 [doi] AB - OBJECTIVE: Eating disorder (ED) symptoms have been studied in adults with other rare genetic conditions but not in Williams syndrome (WS). This study examined the prevalence of ED symptoms in adults with WS and associated clinical and demographic factors. We hypothesized that a proportion would screen positive for an ED, primarily with avoidant/restrictive food intake disorder (ARFID) or binge-eating presentations. METHOD: Adults with WS completed modified versions of the Eating Disorder Assessment for DSM-5 and the Pica, ARFID, and Rumination Disorder Questionnaire, administered as semi-structured interviews by trained research staff. Participants also completed a medical history questionnaire. We used descriptive and between-group analyses to examine clinical and demographic characteristics of ED-positive and ED-negative groups. RESULTS: Of the 86 participants, more than one quarter (n = 24, 28%; 95% CI [20%, 38%]) screened positive for an ED. Adults who screened positive for an ED most commonly had binge-type EDs (n = 15, 63%; 95% CI [43%, 79%]) and ARFID-type EDs (n = 7, 29%; 95% CI [15%, 49%]). Of those who screened positive, 96% reported they had never been previously diagnosed with an ED. DISCUSSION: Our study provides initial evidence of a high frequency of positive ED screens in adults with WS, most commonly ARFID-type and binge-type EDs. Our findings also suggest that, while prevalent in WS, EDs typically go undetected, and that it may be difficult to identify at-risk individuals. There is a need to validate ED screeners for adults with WS to enhance detection and access to care. CI - (c) 2026 Wiley Periodicals LLC. FAU - Dunford, Ashley AU - Dunford A AUID- ORCID: 0000-0003-4460-6437 AD - Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA. AD - Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA. FAU - Renzi, Danielle AU - Renzi D AUID- ORCID: 0009-0001-8189-8531 AD - Genetics & Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Bitar, Thomas AU - Bitar T AUID- ORCID: 0009-0002-8762-2453 AD - Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Gallagher, Aidan AU - Gallagher A AUID- ORCID: 0009-0003-6119-7636 AD - Genetics & Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Thomas, Jennifer J AU - Thomas JJ AUID- ORCID: 0000-0003-2601-581X AD - Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA. AD - Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA. FAU - Thom, Robyn P AU - Thom RP AUID- ORCID: 0000-0002-8026-6970 AD - Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA. AD - Lurie Center for Autism, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Pober, Barbara R AU - Pober BR AUID- ORCID: 0000-0003-4210-7634 AD - Genetics & Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA. AD - Department of Pediatrics (Emeritus), Harvard Medical School, Boston, Massachusetts, USA. LA - eng GR - K24 MH135189/MH/NIMH NIH HHS/United States GR - K24MH135189/MH/NIMH NIH HHS/United States GR - K24MH135189/MH/NIMH NIH HHS/United States PT - Journal Article DEP - 20260325 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM MH - Humans MH - *Williams Syndrome/complications/psychology/epidemiology MH - Adult MH - Female MH - Male MH - *Feeding and Eating Disorders/diagnosis/epidemiology/complications MH - Young Adult MH - Surveys and Questionnaires MH - Middle Aged MH - Prevalence MH - Avoidant Restrictive Food Intake Disorder MH - Adolescent PMC - PMC13020642 MID - NIHMS2149798 OTO - NOTNLM OT - ARFID OT - BED OT - Williams syndrome OT - avoidant/restrictive food intake disorder OT - binge-eating OT - feeding and eating disorder OT - intellectual disability COIS- Conflicts of Interest: Dr. Thomas receives royalties from Cambridge University Press, Oxford University Press, and Routledge for her books on eating disorders. She also receives consulting fees from Equip Health. Dr. Thom receives royalties from Oxford University Press and Springer Publishing. The other authors declare no conflicts of interest. EDAT- 2026/03/25 07:09 MHDA- 2026/07/02 12:34 PMCR- 2026/03/27 CRDT- 2026/03/25 04:53 PHST- 2026/02/12 00:00 [revised] PHST- 2025/11/12 00:00 [received] PHST- 2026/02/16 00:00 [accepted] PHST- 2026/07/02 12:34 [medline] PHST- 2026/03/25 07:09 [pubmed] PHST- 2026/03/25 04:53 [entrez] PHST- 2026/03/27 00:00 [pmc-release] AID - 10.1002/eat.70070 [doi] PST - ppublish SO - Int J Eat Disord. 2026 Jul;59(7):1543-1551. doi: 10.1002/eat.70070. Epub 2026 Mar 25. PMID- 41878459 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260325 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - The use of an augmented reality app to support an exercise intervention for children and young people with cancer: perspectives of users and exercise and healthcare professionals in the FORTEe trial. PG - 1743212 LID - 10.3389/fped.2026.1743212 [doi] LID - 1743212 AB - BACKGROUND: Mobile health (mHealth) technologies are increasingly used in paediatric oncology to promote physical activity, with growing evidence supporting their feasibility and effectiveness. Augmented reality (AR) is emerging as a promising addition, offering interactive features that may enhance participation in exercise for young people. As mHealth tools evolve, understanding user experiences and implementation challenges is essential to inform wider adoption in healthcare. The FORTEe clinical trial evaluates an individualised exercise programme designed for children, adolescents and young adults with cancer (CAYA). This sub-study explores the perspectives of CAYA and exercise and healthcare professionals involved in delivering the exercise intervention (exercise professionals) on the use of a novel AR application (app), designed to facilitate home-based exercise as part of the broader intervention. Key app features include personalised exercise programmes, AR demonstrations using a child-like avatar, and an integrated exercise diary. METHODS: CAYA (9-21 years), and exercise professionals from the FORTEe trial's technology sub-study (six centres) were eligible. To explore experiences and perceptions of the AR app, half-structured interviews were conducted with CAYA and an anonymous online survey administered to exercise professionals. Interview data and open-ended text from survey was analysed using inductive qualitative content analysis. Survey data was analysed using descriptive statistics. RESULTS: A total of 46 CAYA (mean age 13.6 +/- 2.7 years, 39% female) provided feedback on the AR app via interviews, and 31 exercise professionals completed the survey. CAYA and exercise professionals reported generally positive experiences, finding the AR demonstrations novel and engaging. The personalised workouts were valued by both groups. However, both groups reported some technical difficulties that impacted reliability, and that some features, such as the exercise diary, lacked usability. Exercise professionals emphasised the app should complement rather than replace face-to-face sessions. To enhance the app further, both groups suggested incorporating gamification and avatar customisation. CONCLUSION: This study emphasises the potential of AR technology to increase engagement in exercise among CAYA and highlights ways to optimise the technology. While AR shows promise in paediatric oncology care, it should complement in-person exercise interventions. Future development should prioritise user-friendly design, personalised approaches, and equal access for young patients. CI - (c) 2026 Marriott, Solera-Sanchez, Windsor, Straun, Neu, Dreismickenbecker, Lanfranconi, Villa, Wiskemann, Bauer, Gotte, Beller, Spreafico, Zardo, Wright, Faber and Watson. FAU - Marriott, Hayley AU - Marriott H AD - School of Sport, Nutrition and Allied Health Professions, Faculty of Health Science, and Technology, Oxford Brookes University, Oxford, United Kingdom. FAU - Solera-Sanchez, Alba AU - Solera-Sanchez A AD - School of Sport, Nutrition and Allied Health Professions, Faculty of Health Science, and Technology, Oxford Brookes University, Oxford, United Kingdom. FAU - Windsor, Stanley AU - Windsor S AD - School of Sport, Nutrition and Allied Health Professions, Faculty of Health Science, and Technology, Oxford Brookes University, Oxford, United Kingdom. FAU - Straun, Kim AU - Straun K AD - School for Policy Studies, University of Bristol, Bristol, United Kingdom. FAU - Neu, Marie A AU - Neu MA AD - University Medical Center of the Johannes Gutenberg-University Mainz, Childhood Cancer Center Mainz, Mainz, Germany. FAU - Dreismickenbecker, Elias AU - Dreismickenbecker E AD - University Medical Center of the Johannes Gutenberg-University Mainz, Childhood Cancer Center Mainz, Mainz, Germany. FAU - Lanfranconi, Francesca AU - Lanfranconi F AD - Fondazione Monza e Brianza per Il Bambino e La Sua Mamma, Monza, Italy. FAU - Villa, Emanuele AU - Villa E AD - Fondazione Monza e Brianza per Il Bambino e La Sua Mamma, Monza, Italy. FAU - Wiskemann, Joachim AU - Wiskemann J AD - Exercise Oncology Research Group, Department of Medical Oncology, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and the Heidelberg University Hospital, Heidelberg, Germany. FAU - Bauer, Nikolai AU - Bauer N AD - Exercise Oncology Research Group, Department of Medical Oncology, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and the Heidelberg University Hospital, Heidelberg, Germany. FAU - Gotte, Miriam AU - Gotte M AD - University Hospital Essen, West German Cancer Center, Essen, Germany. FAU - Beller, Ronja AU - Beller R AD - Clinics for Paediatrics III, Department of Paediatric Haematology/Oncology, West German Cancer Centre, University Hospital Essen, Essen, Germany. FAU - Spreafico, Filippo AU - Spreafico F AD - Oncology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy. FAU - Zardo, William AU - Zardo W AD - Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. FAU - Wright, Peter AU - Wright P AD - School of Sport, Nutrition and Allied Health Professions, Faculty of Health Science, and Technology, Oxford Brookes University, Oxford, United Kingdom. FAU - Faber, Joerg AU - Faber J AD - University Medical Center of the Johannes Gutenberg-University Mainz, Childhood Cancer Center Mainz, Mainz, Germany. FAU - Watson, Eila AU - Watson E AD - Oxford Institute of Applied Health Research, Faculty of Health Science, and Technology, Oxford Brookes University, Oxford, United Kingdom. LA - eng PT - Journal Article DEP - 20260309 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13006567 OTO - NOTNLM OT - augmented reality OT - childhood cancer OT - exercise OT - exercise oncology OT - smartphone app COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/25 07:09 MHDA- 2026/03/25 07:10 PMCR- 2026/03/09 CRDT- 2026/03/25 04:31 PHST- 2025/11/10 00:00 [received] PHST- 2026/02/12 00:00 [revised] PHST- 2026/02/16 00:00 [accepted] PHST- 2026/03/25 07:10 [medline] PHST- 2026/03/25 07:09 [pubmed] PHST- 2026/03/25 04:31 [entrez] PHST- 2026/03/09 00:00 [pmc-release] AID - 10.3389/fped.2026.1743212 [doi] PST - epublish SO - Front Pediatr. 2026 Mar 9;14:1743212. doi: 10.3389/fped.2026.1743212. eCollection 2026. PMID- 41878288 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260325 LR - 20260813 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - Associations between perceived physical literacy and physical fitness tests among the adult population. PG - 1783118 LID - 10.3389/fspor.2026.1783118 [doi] LID - 1783118 AB - INTRODUCTION: The multidimensional concept of physical literacy (PL) is increasingly recognized as a holistic framework supporting lifelong physical activity. Although research is growing, empirical evidence remains limited and focused mainly on children and adolescents. In adults the relationship between subjectively measured (perceived) PL and objectively measured physical fitness tests is still unclear. The aim of this study was therefore to examine associations between overall and domain-specific perceived PL and multiple components of physical fitness in an adult population. METHODS: An exploratory cross-sectional study was conducted with 180 adults (60% women; mean age 40.71 +/- 15.79 years), recruited during community-based physical activity education events in rural Austria. Perceived PL was assessed using the Perceived Physical Literacy Questionnaire (PPLQ), which captures six domains: motivation, confidence, physical competence, knowledge, understanding, and physical activity behavior. Physical fitness was evaluated through a series of field-based tests assessing cardiorespiratory fitness, muscular strength, flexibility of the upper and lower extremities, balance, and reaction time. Spearman correlation coefficients were calculated for the total sample and subsamples stratified by gender and age (<45/ >/= 45 years). In line with the exploratory nature of the study, interpretation focused exclusively on effect sizes following Cohen's conventions. RESULTS: Across all fitness parameters, the strongest correlations emerged for overall PL and the physical competence domain, followed by the physical activity behavior and confidence domains. In turn, the weakest correlations were observed for the motivation, knowledge, and understanding domains. Overall, correlations ranged predominantly from small-to-moderate, with notable variation across gender- and age-specific subgroups; in men and younger adults, correlations were generally stronger. CONCLUSION: This study provides new insights into the relationship between overall/domain-specific perceived PL and physical fitness tests in the adult population, particularly regarding less commonly explored fitness parameters such as upper extremity flexibility, reaction time, and balance. Given the exploratory nature of the study, future research with larger, more diverse, and probability-based samples is needed to strengthen both the internal and external validity of these findings. CI - (c) 2026 Holler, Dohr, Tuttner, Amort, van Poppel and Jaunig. FAU - Holler, Peter AU - Holler P AD - Department of Human Movement Science, Sport and Health, University of Graz, Graz, Austria. AD - FH JOANNEUM-University of Applied Sciences, Institute of Health and Tourism Management, Bad Gleichenberg, Austria. AD - Sport Science Laboratory, FH JOANNEUM-University of Applied Sciences, Bad Gleichenberg, Austria. FAU - Dohr, Sandra AU - Dohr S AD - Geriatric Health Centres of the City of Graz, Albert Schweitzer Institute for Geriatrics and Gerontology, Graz, Austria. AD - Department of Management, University of Klagenfurt, Klagenfurt, Austria. FAU - Tuttner, Silvia AU - Tuttner S AD - FH JOANNEUM-University of Applied Sciences, Institute of Health and Tourism Management, Bad Gleichenberg, Austria. FAU - Amort, Frank Michael AU - Amort FM AD - FH JOANNEUM-University of Applied Sciences, Institute of Health and Tourism Management, Bad Gleichenberg, Austria. FAU - van Poppel, Mireille AU - van Poppel M AD - Department of Human Movement Science, Sport and Health, University of Graz, Graz, Austria. FAU - Jaunig, Johannes AU - Jaunig J AD - Department of Human Movement Science, Sport and Health, University of Graz, Graz, Austria. LA - eng PT - Journal Article DEP - 20260309 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13006595 OTO - NOTNLM OT - adults OT - cross-sectional study OT - fitness tests OT - perceived physical literacy OT - physical activity OT - physical competence OT - physical fitness OT - physical literacy COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer AM declared a past co-authorship with the author JJ to the handling editor. EDAT- 2026/03/25 07:09 MHDA- 2026/03/25 07:10 PMCR- 2026/03/09 CRDT- 2026/03/25 04:29 PHST- 2026/01/07 00:00 [received] PHST- 2026/02/06 00:00 [revised] PHST- 2026/02/09 00:00 [accepted] PHST- 2026/03/25 07:10 [medline] PHST- 2026/03/25 07:09 [pubmed] PHST- 2026/03/25 04:29 [entrez] PHST- 2026/03/09 00:00 [pmc-release] AID - 10.3389/fspor.2026.1783118 [doi] PST - epublish SO - Front Sports Act Living. 2026 Mar 9;8:1783118. doi: 10.3389/fspor.2026.1783118. eCollection 2026. PMID- 41878060 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260325 LR - 20260920 IS - 2473-4039 (Electronic) IS - 2473-4039 (Linking) VI - 10 IP - 4 DP - 2026 Apr TI - Rethinking race-based interpretation in pediatric densitometry: a scoping review. PG - ziag028 LID - 10.1093/jbmrpl/ziag028 [doi] LID - ziag028 AB - As pediatric populations in the United States (US) become increasingly diverse, current practices for interpreting bone density using DXA in children warrant reevaluation. The International Society for Clinical Densitometry currently recommends adjusting pediatric bone density Z-scores by race, sex, and age. However, race-based adjustments risk reinforcing disparities and perpetuating systemic inequities in pediatric bone health assessment. We conducted a scoping review of studies examining racial and ethnic differences in BMD among healthy US children, identifying 3960 records across 4 databases, of which 54 met inclusion criteria. Across these studies, reporting of race and ethnicity was inconsistent: although nearly all relied on self- or parent-report, none provided explicit definitions, and only 13% confirmed concordance across grandparents. Fifty percent of studies reported statistically significant racial differences in BMD, yet most did so without comprehensive covariate adjustment. By contrast, studies that accounted for height, lean mass, and pubertal status frequently found that differences attenuated or disappeared. These findings underscore the need to critically reconsider race-based adjustments in pediatric DXA interpretation. Developing and validating race-neutral reference standards, with attention to structural determinants and biologically relevant measures, such as stature, body composition, and pubertal timing, is essential for achieving a more equitable and clinically meaningful assessment of pediatric bone health. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research. FAU - Ramadan, Amira AU - Ramadan A AD - Department of Pediatrics, Division of Endocrinology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States. FAU - Moore, Zakora AU - Moore Z AD - Department of Pediatrics, Division of Endocrinology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States. FAU - Ahmed, Usman A AU - Ahmed UA AD - Department of Pediatrics, Division of Endocrinology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States. FAU - Tantivit, Nessa AU - Tantivit N AD - Department of Pediatrics, Division of Endocrinology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States. FAU - Aiylam, Dhriti AU - Aiylam D AD - Department of Pediatrics, Division of Endocrinology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States. FAU - Rotman, Chloe AU - Rotman C AD - Medical Library, Boston Children's Hospital, Boston, MA 02115, United States. FAU - Pendleton, Alicia AU - Pendleton A AD - Department of Pediatrics, Division of Endocrinology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States. FAU - Petty, Carter R AU - Petty CR AD - Biostatistics and Research Design (BARD) Center, Boston Children's Hospital, Boston, MA 02115, United States. FAU - DiMeo, Mali AU - DiMeo M AD - Department of Pediatrics, Division of Endocrinology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States. FAU - Grice, Amanda AU - Grice A AD - Office of Health Equity and Inclusion, Sandra L. Fenwick Institute for Pediatric Health Equity and Inclusion, Department of Health Affairs, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States. FAU - Ward, Valerie L AU - Ward VL AD - Office of Health Equity and Inclusion, Sandra L. Fenwick Institute for Pediatric Health Equity and Inclusion, Department of Health Affairs, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States. AD - Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115 United States. FAU - Jacobsen, Christina M AU - Jacobsen CM AD - Department of Pediatrics, Division of Endocrinology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States. FAU - Renthal, Nora E AU - Renthal NE AUID- ORCID: 0000-0002-8186-4462 AD - Department of Pediatrics, Division of Endocrinology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States. LA - eng GR - T32 DK007260/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Review DEP - 20260312 PL - England TA - JBMR Plus JT - JBMR plus JID - 101707013 PMC - PMC13007872 OTO - NOTNLM OT - BMD OT - DXA OT - ethnicity OT - health disparities OT - normative curves OT - pediatric bone density OT - pediatric reference data OT - race COIS- The authors declare no conflicts of interest. EDAT- 2026/03/25 07:09 MHDA- 2026/03/25 07:10 PMCR- 2026/03/12 CRDT- 2026/03/25 04:27 PHST- 2025/09/29 00:00 [received] PHST- 2026/01/16 00:00 [revised] PHST- 2026/02/16 00:00 [accepted] PHST- 2026/03/25 07:10 [medline] PHST- 2026/03/25 07:09 [pubmed] PHST- 2026/03/25 04:27 [entrez] PHST- 2026/03/12 00:00 [pmc-release] AID - ziag028 [pii] AID - 10.1093/jbmrpl/ziag028 [doi] PST - epublish SO - JBMR Plus. 2026 Mar 12;10(4):ziag028. doi: 10.1093/jbmrpl/ziag028. eCollection 2026 Apr. PMID- 41876144 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 2056-5933 (Electronic) IS - 2056-5933 (Linking) VI - 12 IP - 1 DP - 2026 Mar 24 TI - Severe impairments in work ability among patients with axSpA and PsA: results from the RABBIT-SpA Register. LID - 10.1136/rmdopen-2025-006338 [doi] LID - e006338 AB - OBJECTIVES: To assess the frequency and extent of work ability impairment and explore differences in its degree in relation to sociodemographic, clinical and patient-reported factors in patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA). METHODS: This cross-sectional analysis used data from the prospective RABBIT-SpA cohort, including patients aged 18-65 years with physician-confirmed axSpA or PsA. Work ability was assessed in both the axSpA and PsA cohorts using the Work Ability Index (WAI; 7-49 points, higher scores=better work ability), categorised as good/excellent (>/=37) or moderate/poor (/=0.64) onto at least 1 factor (factor 1 loadings, 0.64-0.98; factor 2, 0.96-0.98; factor 3, 0.95-0.97; factor 4, -0.86 to 1.01; factor 5, 0.68-0.93; factor 6, 0.82-0.94). Greater sleep irregularity was associated with transdiagnostic mental health symptoms cross-sectionally, but not prospectively (beta, 0.06 [95% CI, 0.02-0.10] to 0.12 [95% CI, 0.08-0.16]). Shorter duration was associated with total, internalizing, externalizing, and attention symptoms cross-sectionally (beta, -0.06 [95% CI, -0.10 to -0.01] to -0.11 [95% CI, -0.15 to -0.06]) and total, attention, and psychotic symptoms 1 year later. CONCLUSIONS AND RELEVANCE: In this study, wearable Fitbit data provide empirical support for multidimensional frameworks of sleep health in adolescence. Although effect sizes were small, sleep irregularity and duration emerged as key dimensions with relevance to mental health. These findings establish a foundation for future investigations, including examining within-person patterns of the 6 dimensions, extending to older adolescence, investigating associations with other health outcomes, replicating with research-grade actigraphy devices, and suggesting potential targets for pediatric sleep interventions. FAU - Cooper, Rebecca E AU - Cooper RE AD - Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, Massachusetts. AD - Department of Psychiatry, Harvard Medical School, Boston, Massachusetts. FAU - Baker, Amanda E AU - Baker AE AD - Center for Children and Families, Florida International University, Miami. FAU - Quick, Allysa D AU - Quick AD AD - UPMC Western Psychiatric Hospital, Pittsburgh, Pennsylvania. FAU - Yu, Lan AU - Yu L AD - Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. FAU - Gonzalez, Raul AU - Gonzalez R AD - Center for Children and Families, Florida International University, Miami. FAU - Clark, Duncan B AU - Clark DB AD - Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania. FAU - McMakin, Dana L AU - McMakin DL AD - Center for Children and Families, Florida International University, Miami. FAU - Soehner, Adriane M AU - Soehner AM AD - Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania. FAU - Jalbrzikowski, Maria AU - Jalbrzikowski M AD - Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, Massachusetts. AD - Department of Psychiatry, Harvard Medical School, Boston, Massachusetts. FAU - Wallace, Meredith L AU - Wallace ML AD - Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania. AD - Department of Statistics, University of Pittsburgh, Pittsburgh, Pennsylvania. AD - Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania. LA - eng GR - U24 DA041147/DA/NIDA NIH HHS/United States GR - U01 DA041120/DA/NIDA NIH HHS/United States GR - R01 HL169318/HL/NHLBI NIH HHS/United States GR - U01 DA051018/DA/NIDA NIH HHS/United States GR - R01 MH124828/MH/NIMH NIH HHS/United States GR - U24 DA041123/DA/NIDA NIH HHS/United States GR - U01 DA051038/DA/NIDA NIH HHS/United States GR - R01 MH116005/MH/NIMH NIH HHS/United States GR - U01 DA051037/DA/NIDA NIH HHS/United States GR - U01 DA051016/DA/NIDA NIH HHS/United States GR - U01 DA041106/DA/NIDA NIH HHS/United States GR - U01 DA041117/DA/NIDA NIH HHS/United States GR - U01 DA041148/DA/NIDA NIH HHS/United States GR - R21 MH127294/MH/NIMH NIH HHS/United States GR - R01 MH129636/MH/NIMH NIH HHS/United States GR - U01 DA041174/DA/NIDA NIH HHS/United States GR - U01 DA051039/DA/NIDA NIH HHS/United States GR - P50 DA046346/DA/NIDA NIH HHS/United States GR - U01 DA041093/DA/NIDA NIH HHS/United States GR - U01 MH136020/MH/NIMH NIH HHS/United States GR - U01 DA041134/DA/NIDA NIH HHS/United States GR - U01 DA041022/DA/NIDA NIH HHS/United States GR - U01 DA041156/DA/NIDA NIH HHS/United States GR - U01 DA050987/DA/NIDA NIH HHS/United States GR - U01 DA041025/DA/NIDA NIH HHS/United States GR - U01 DA050989/DA/NIDA NIH HHS/United States GR - U01 DA041089/DA/NIDA NIH HHS/United States GR - U01 DA050988/DA/NIDA NIH HHS/United States GR - U01 DA041028/DA/NIDA NIH HHS/United States GR - U01 DA041048/DA/NIDA NIH HHS/United States PT - Journal Article PT - Multicenter Study PL - United States TA - JAMA Pediatr JT - JAMA pediatrics JID - 101589544 SB - IM MH - Humans MH - Female MH - Adolescent MH - Male MH - Child MH - *Mental Disorders/diagnosis MH - Longitudinal Studies MH - *Sleep/physiology MH - *Wearable Electronic Devices MH - *Mental Health MH - Prospective Studies MH - Sleep Duration MH - *Sleep Wake Disorders/diagnosis PMC - PMC13010210 MID - NIHMS2152495 EDAT- 2026/03/23 13:03 MHDA- 2026/05/04 12:34 PMCR- 2026/03/26 CRDT- 2026/03/23 11:33 PHST- 2026/05/04 12:34 [medline] PHST- 2026/03/23 13:03 [pubmed] PHST- 2026/03/23 11:33 [entrez] PHST- 2026/03/26 00:00 [pmc-release] AID - 2846180 [pii] AID - 10.1001/jamapediatrics.2026.0335 [doi] PST - ppublish SO - JAMA Pediatr. 2026 May 1;180(5):535-545. doi: 10.1001/jamapediatrics.2026.0335. PMID- 41870301 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260713 IS - 1533-4287 (Electronic) IS - 1064-8011 (Linking) VI - 40 IP - 6 DP - 2026 Jun 1 TI - Definition of Substantial Athletic Benefit and Satisfaction of a Neuromuscular and Strength Training Program for Ballet Dancers. PG - e629-e638 LID - 10.1519/JSC.0000000000005400 [doi] AB - Crampton, CT, Smith, ST, and Noyes, FR. Definition of substantial athletic benefit and satisfaction of a neuromuscular and strength training program for ballet dancers. J Strength Cond Res 40(6): e629-e638, 2026-The aim of this prospective cross-sectional study was to assess the psychometrics and performance outcomes on preprofessional ballet dancers undergoing a neuromuscular and strength training program. We hypothesized that ballet dancers would perceive substantial benefits of this training program and significantly improve performance outcomes. Twenty-eight dancers from a preprofessional ballet training program volunteered to participate in a 6-week neuromuscular and strength training program. The dancers completed a psychometric questionnaire and objective testing before and after the training program. The psychometric questionnaire evaluated individual substantial athletic benefits and satisfaction of the training program. Objective testing included the triple hop test and T-Drill hop test to assess the training program on improving horizontal distance hopped, time hopped, limb symmetry, and landing mechanics. The dancers reported high perceived substantial benefits in 79% (22 of 28) for teaching proper take-off and landing mechanics, and in 96% (27 of 28) for the program challenging and preparing them for dance activities. A high dancer satisfaction rating was reported in 93% (26 of 28 dancers) for the training program. A significant increase in distance hopped occurred in right and left lower limbs on the triple hop test ( p < 0.001). A significant decrease in time to complete the T-Drill hop test was reported on right and left lower limbs ( p < 0.001). The psychometric results of the high substantial athletic benefits, major overall satisfaction, and increased hop drill performance warrant the recommendation of this training program for ballet dancers. CI - Copyright (c) 2026 National Strength and Conditioning Association. FAU - Crampton, Carolyn T AU - Crampton CT AD - Cincinnati SportsMedicine Research and Education Foundation, Mercy Health, Cincinnati, Ohio. FAU - Smith, Stephanie T AU - Smith ST FAU - Noyes, Frank R AU - Noyes FR LA - eng PT - Journal Article DEP - 20260320 PL - United States TA - J Strength Cond Res JT - Journal of strength and conditioning research JID - 9415084 SB - IM MH - Humans MH - *Dancing/psychology/physiology MH - Female MH - *Resistance Training/methods MH - Cross-Sectional Studies MH - Prospective Studies MH - Young Adult MH - Psychometrics MH - *Personal Satisfaction MH - Male MH - Surveys and Questionnaires MH - *Athletic Performance/psychology/physiology MH - Adult MH - Adolescent OTO - NOTNLM OT - ballet neuromuscular training OT - ballet strength training OT - dance medicine OT - injury prevention OT - psychometric analysis EDAT- 2026/03/23 13:04 MHDA- 2026/05/22 12:34 CRDT- 2026/03/23 10:22 PHST- 2026/05/22 12:34 [medline] PHST- 2026/03/23 13:04 [pubmed] PHST- 2026/03/23 10:22 [entrez] AID - 00124278-990000000-00931 [pii] AID - 10.1519/JSC.0000000000005400 [doi] PST - ppublish SO - J Strength Cond Res. 2026 Jun 1;40(6):e629-e638. doi: 10.1519/JSC.0000000000005400. Epub 2026 Mar 20. PMID- 41868177 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 1177-8881 (Electronic) IS - 1177-8881 (Linking) VI - 20 DP - 2026 TI - Machine Learning Models Reveal New Risk Factors for Sub-/Supra-Therapeutic Concentrations of Sirolimus in Children with Vascular Anomalies. PG - 563637 LID - 10.2147/DDDT.S563637 [doi] LID - 563637 AB - INTRODUCTION: Sirolimus, also known as rapamycin, is an mTOR receptor inhibitor that suppresses cell proliferation and angiogenesis, demonstrating efficacy against multiple types of vascular anomalies. However, sub-therapeutic concentrations (below effective levels) and supra-therapeutic concentrations (leading to adverse reactions) of sirolimus may both negatively impact patient treatment outcomes. This study aimed to establish optimal models to predict the risk of sirolimus exposure using machine learning, ensure that sirolimus blood concentrations remain within the therapeutic range, and thus enhance the efficacy and safety of sirolimus therapy for children with vascular anomalies. METHODS: We retrospectively analyzed 134 sirolimus therapeutic drug monitoring (TDM) measurements from 49 patients. Data were randomly split into training (80%) and testing (20%) sets, with an additional temporal cohort for external validation. Six machine learning models were developed to predict sub-therapeutic and supra-therapeutic risks, and evaluated primarily by the area under the receiver operating characteristic curve (AUROC) and Brier score. The optimal model was interpreted using SHapley Additive exPlanations (SHAP) analysis. RESULTS: The sub-therapeutic risk model included body mass index (BMI), white blood cells (WBC), mean corpuscular hemoglobin (MCH), triglycerides (TG), and total bilirubin (TBIL); while the supra-therapeutic model comprised height, platelet count (PLT), alanine aminotransferase (ALT), high-density lipoprotein cholesterol (HDL), and total cholesterol (TC). The multilayer perceptron (MLP) and extreme gradient boosting (XGB) models showed optimal performance for sub-therapeutic (AUROC = 0.646, Brier = 0.190) and supra-therapeutic (AUROC = 0.825, Brier = 0.143) risk prediction, respectively, with consistent results in temporal validation (AUROC: 0.678, Brier = 0.190 and AUROC: 0.767, Brier = 0.190). CONCLUSION: This study is the first to use machine learning models to predict the risk of sub- or supra-therapeutic sirolimus concentrations in vascular anomalies children. By enabling personalized exposure risk prediction, the dosing accuracy of sirolimus for the treatment of children with vascular anomalies can be optimized, thereby enhancing effectiveness and safety. CI - (c) 2026 Hu et al. FAU - Hu, Ya-Hui AU - Hu YH AD - Pharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. FAU - Li, Wan-Xia AU - Li WX AD - School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. AD - Department of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China. FAU - Fan, Lin AU - Fan L AD - Pharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. FAU - Zhou, Zhou AU - Zhou Z AD - Department of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China. FAU - Guo, Hong-Li AU - Guo HL AUID- ORCID: 0000-0002-6660-8145 AD - Pharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. FAU - Chen, Feng AU - Chen F AD - Pharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. FAU - Zou, Jian-Jun AU - Zou JJ AUID- ORCID: 0000-0003-0886-3153 AD - Department of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China. FAU - Ji, Yi AU - Ji Y AD - Department of Burns and Plastic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. FAU - Xu, Jin AU - Xu J AD - Pharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. FAU - Shen, Wei-Min AU - Shen WM AD - Department of Burns and Plastic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. LA - eng PT - Journal Article DEP - 20260108 PL - New Zealand TA - Drug Des Devel Ther JT - Drug design, development and therapy JID - 101475745 RN - W36ZG6FT64 (Sirolimus) SB - IM MH - Humans MH - *Sirolimus/administration & dosage/blood/therapeutic use MH - *Machine Learning MH - Risk Factors MH - Retrospective Studies MH - Female MH - Child MH - Male MH - Child, Preschool MH - Predictive Learning Models MH - Drug Monitoring MH - Infant MH - *Vascular Malformations/drug therapy MH - Prediction Algorithms PMC - PMC13000750 OTO - NOTNLM OT - children OT - concentration risk prediction OT - machine learning OT - sirolimus OT - vascular anomalies COIS- The authors declare no conflicts of interest in this work. EDAT- 2026/03/23 06:31 MHDA- 2026/03/23 13:03 PMCR- 2026/01/08 CRDT- 2026/03/23 05:52 PHST- 2025/08/27 00:00 [received] PHST- 2025/12/12 00:00 [accepted] PHST- 2026/03/23 13:03 [medline] PHST- 2026/03/23 06:31 [pubmed] PHST- 2026/03/23 05:52 [entrez] PHST- 2026/01/08 00:00 [pmc-release] AID - 563637 [pii] AID - 10.2147/DDDT.S563637 [doi] PST - epublish SO - Drug Des Devel Ther. 2026 Jan 8;20:563637. doi: 10.2147/DDDT.S563637. eCollection 2026. PMID- 41867934 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260323 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Relationships among children's muscular strength, neuromuscular control, and resilience. PG - 1743647 LID - 10.3389/fped.2026.1743647 [doi] LID - 1743647 AB - INTRODUCTION: Children who participate in recess interventions demonstrate increased upper- and lower-body muscular strength (MusS), neuromuscular control (NC), and resilience. However, to measure the effectiveness of recess interventions, identifying the relationship between physical and psychological assessments is necessary for reliability and consistency. Therefore, this study explores the relationships and variable predictions among MusS, NC, and resilience assessments in fourth- and fifth-grade children at two time points during one school year. METHODS: A total of 164 fourth- and fifth-grade children participated in MusS (standing broad jump, push-ups, single-leg three-hop, and average grip strength), NC (side-step), and resilience (Child and Youth Resilience Measure-Revised) assessments. A single intraclass correlation coefficient was calculated in September (Time 1) and January (Time 2) to evaluate the reliability of each assessment. Next, Pearson product correlations and multiple linear regression analyses were conducted to assess outcomes. RESULTS: Times 1 and 2 had positive, moderate, and significant correlations among the following MusS assessments: standing broad jump and average single-leg three-hop, standing broad jump and push-up, and average single-leg three-hop and push-up (p < 0.01). NC and resilience had no meaningful correlations with the other assessments. Regression analyses further revealed that push-up performance was a significant predictor of standing broad jump performance at Times 1 and 2 (p < 0.001). CONCLUSIONS: MusS assessments were practical, reliable, time-efficient, and low cost for this age group. Therefore, these elements should be taken into consideration to measure the effectiveness of recess or physical activity interventions. In addition, the results revealed correlations between upper- and lower-body MusS assessments. The relationship between the standing broad jump and push-ups highlights the interconnective nature of the upper and lower MusS. This raises the question of why resilience and NC were not related to each other or to MusS assessments. Given the exploratory nature and short duration of this study, further research is needed to validate these findings and to determine whether there are more effective NC and resilience assessments to use with this age group. CI - (c) 2026 Wagner, Esposito, Braun-Trocchio, von Borck and Rhea. FAU - Wagner, Lauren M AU - Wagner LM AD - Department of Kinesiology, Texas Christian University, Fort Worth, TX, United States. FAU - Esposito, Phil AU - Esposito P AD - Department of Kinesiology, Texas Christian University, Fort Worth, TX, United States. FAU - Braun-Trocchio, Robyn AU - Braun-Trocchio R AD - Department of Kinesiology, Texas Christian University, Fort Worth, TX, United States. FAU - von Borck, Hailey G AU - von Borck HG AD - Department of Kinesiology, Texas Christian University, Fort Worth, TX, United States. FAU - Rhea, Deborah J AU - Rhea DJ AD - Department of Kinesiology, Texas Christian University, Fort Worth, TX, United States. LA - eng PT - Journal Article DEP - 20260306 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13002809 OTO - NOTNLM OT - assessment OT - child performance OT - fitness OT - muscular strength OT - neuromuscular control OT - resilience COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/23 06:32 MHDA- 2026/03/23 06:33 PMCR- 2026/03/06 CRDT- 2026/03/23 05:50 PHST- 2025/11/11 00:00 [received] PHST- 2026/02/05 00:00 [revised] PHST- 2026/02/09 00:00 [accepted] PHST- 2026/03/23 06:33 [medline] PHST- 2026/03/23 06:32 [pubmed] PHST- 2026/03/23 05:50 [entrez] PHST- 2026/03/06 00:00 [pmc-release] AID - 10.3389/fped.2026.1743647 [doi] PST - epublish SO - Front Pediatr. 2026 Mar 6;14:1743647. doi: 10.3389/fped.2026.1743647. eCollection 2026. PMID- 41864152 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260730 IS - 1872-8243 (Electronic) IS - 1386-5056 (Linking) VI - 214 DP - 2026 Jul 1 TI - Research using smartwatches for the measurement of physical activity, sedentary behavior, and sleep: A scoping review. PG - 106370 LID - S1386-5056(26)00110-3 [pii] LID - 10.1016/j.ijmedinf.2026.106370 [doi] AB - OBJECTIVE: The objective of this scoping review is to map the evidence on using smartwatches to objectively measure physical activity (PA), sedentary behavior (SB), and sleep in children, adolescents, adults, and older adults. METHODS: This review followed the Joanna Briggs Institute (JBI) guidelines for scoping reviews, following a previously published protocol. The searches were conducted in January 2022 on Medline, Scopus, Web of Science, IEEE Xplore Digital Library, Scielo, LILACS, Health Technology Assessment Database, Cochrane clinical trials, and clinical trials. The screening was performed independently by two authors. A narrative synthesis was used. RESULTS: After the electronic search, 5,925 records were identified and 2,008 duplicates removed. Screening of 3,917 titles and abstracts resulted in 491 full-text articles assessed for eligibility. A total of 427 studies were excluded for not meeting inclusion criteria, with one study added after author contact. Thus, 64 of these studies were included. Sample sizes ranged widely from 4 to 6,454 participants, with most studies (80.9%) including 100 or fewer participants. Most studies were conducted in the United States (46.9%), followed by China (9.4%). A total of 18 different smartwatch brands were identified, with Apple(R) being the most investigated (46.9%), followed by Samsung(R) (15.6), Fitbit(R) (14.1%), Motorola(R) (10.9%), Polar(R) (10.9%), Garmin(R) (9.4%), Asus(R) (3.1%), and others (1.6% each. Smartwatches were primarily used to validate measurements of PA, SB, and/or sleep parameters, followed by their use in assessing these variables as exposures or outcomes, testing feasibility, supporting self-monitoring, and other purposes. The most frequently measured variables were steps, total sleep time, and SB. CONCLUSION: This review can help studies, interventions, and health professionals that aim to use this technology as a measurement instrument, as well as help end users who use it on a daily basis. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - da Silva, Jose Francisco AU - da Silva JF AD - Postgraduate Program in Physical Education, University of Pernambuco, Recife, Pernambuco, Brazil; Department of Physical Education, Faculdade Pernambucana de Saude, Recife, Pernambuco, Brazil. FAU - Germano-Soares, Antonio Henrique AU - Germano-Soares AH AD - Department of Physical Education, Faculdade Pernambucana de Saude, Recife, Pernambuco, Brazil; Health Research and Innovation Science Centre, Faculty of Health Sciences, Klaipeda University, Klaipeda, Lithuania. FAU - de Oliveira, Tuillamys Virginio AU - de Oliveira TV AD - Department of Physical Education, Faculdade Pernambucana de Saude, Recife, Pernambuco, Brazil. FAU - Barbosa Silva, Luis Carlos AU - Barbosa Silva LC AD - Postgraduate Program in Physical Education, University of Pernambuco, Recife, Pernambuco, Brazil. FAU - Barbosa Filho, Valter Cordeiro AU - Barbosa Filho VC AD - Program on Collective Health, Ceara State University, Fortaleza, Ceara, Brazil. FAU - de Aguiar Silva, Thiago Coelho AU - de Aguiar Silva TC AD - Department of Physical Education, University of Pernambuco, Recife, Pernambuco, Brazil. FAU - Tassitano, Rafael Miranda AU - Tassitano RM AD - Department of Health and kinesiology, University of Illinois Urbana-Champaign. Illinois, United States. Electronic address: rafaelmt@illinois.edu. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260317 PL - Ireland TA - Int J Med Inform JT - International journal of medical informatics JID - 9711057 SB - IM MH - Humans MH - *Sedentary Behavior MH - *Sleep/physiology MH - *Exercise MH - Digital Health MH - Child MH - Adolescent MH - Adult OTO - NOTNLM OT - Mhealth OT - Movement behaviors OT - Smartwatch OT - Wearable electronic devices OT - Wristwatch COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/03/22 06:06 MHDA- 2026/04/25 00:34 CRDT- 2026/03/21 19:17 PHST- 2024/08/05 00:00 [received] PHST- 2026/02/25 00:00 [revised] PHST- 2026/03/01 00:00 [accepted] PHST- 2026/04/25 00:34 [medline] PHST- 2026/03/22 06:06 [pubmed] PHST- 2026/03/21 19:17 [entrez] AID - S1386-5056(26)00110-3 [pii] AID - 10.1016/j.ijmedinf.2026.106370 [doi] PST - ppublish SO - Int J Med Inform. 2026 Jul 1;214:106370. doi: 10.1016/j.ijmedinf.2026.106370. Epub 2026 Mar 17. PMID- 41864088 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260810 IS - 1532-1983 (Electronic) IS - 0261-5614 (Linking) VI - 60 DP - 2026 May TI - Muscle atrophy associated with glucagon-like Peptide-1 receptor agonists: A population-based observational study. PG - 106620 LID - S0261-5614(26)00047-6 [pii] LID - 10.1016/j.clnu.2026.106620 [doi] AB - Background and AimEmerging evidence suggests that weight loss associated with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may be in part attributable to changes in lean mass, which has potential clinical implications. This study evaluates the disproportionate reporting of muscle atrophy in association with GLP-1 RA therapy using real-world global data.. MethodsWe analyzed reports of muscle atrophy submitted to the FDA Adverse Event Reporting System (FAERS) database from October 2003 to March 2024 using the validated pharmacovigilance tool OpenVigil 2.1. Disproportionality was assessed using reporting odds ratios (RORs) with 95 % confidence intervals (CIs), the standard metric for pharmacovigilance signal detection worldwide. To contextualize associations, disproportionality estimates were calculated using niacin, simvastatin, and the complete FAERS database (all other drugs) as comparators. ResultsA total of 142 cases of muscle atrophy were identified with GLP-1 RA therapy, the majority occurring in adults aged 18-64 years (43 % female, 57 % male). Disproportionality analysis showed pharmacovigilance signals for semaglutide (ROR = 2.39, 95 % CI = 1.63-3.52) and tirzepatide (ROR = 1.69, 95 % CI = 1.14-2.50), indicating increased reporting of muscle atrophy relative to all other drugs in FAERS. In contrast, exenatide (ROR = 0.26, 95 % CI = 0.12-0.55) and liraglutide (ROR = 0.27, 95 % CI = 0.09-0.83) were associated with significantly lower reporting odds. All significant signals satisfied thresholds of p < 0.05 and IC(025) > 0.. ConclusionsCertain GLP-1 receptor agonists demonstrate a pharmacovigilance signal of disproportionate reporting of muscle atrophy. These findings should be interpreted as signal detection rather than evidence of causality and highlight the need for future studies incorporating objective measures of muscle mass and function.. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Kwan, Angela T H AU - Kwan ATH AD - Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Electronic address: angela.kwan@mail.utoronto.ca. FAU - Lakhani, Moiz AU - Lakhani M AD - Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Electronic address: mlakh088@uottawa.ca. FAU - McIntyre, Roger S AU - McIntyre RS AD - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada. Electronic address: roger.mcintyre@bcdf.org. LA - eng PT - Journal Article PT - Observational Study DEP - 20260304 PL - England TA - Clin Nutr JT - Clinical nutrition (Edinburgh, Scotland) JID - 8309603 RN - 9P1872D4OL (Exenatide) RN - 0 (Glucagon-Like Peptide-1 Receptor) RN - 0 (Glucagon-Like Peptide-1 Receptor Agonists) RN - 62340-29-8 (Glucagon-Like Peptides) RN - 0 (Hypoglycemic Agents) RN - 839I73S42A (Liraglutide) RN - 53AXN4NNHX (Semaglutide) RN - OYN3CCI6QE (Tirzepatide) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - Adverse Drug Reaction Reporting Systems/statistics & numerical data MH - Exenatide/adverse effects MH - Glucagon-Like Peptide-1 Receptor MH - *Glucagon-Like Peptide-1 Receptor Agonists MH - Glucagon-Like Peptides/adverse effects MH - *Hypoglycemic Agents/adverse effects MH - Liraglutide/adverse effects MH - *Muscular Atrophy/chemically induced/epidemiology MH - Pharmacovigilance MH - Semaglutide MH - Tirzepatide MH - United States OTO - NOTNLM OT - FAERS OT - Glucagon-like Peptide-1 receptor agonists (GLP-1 RAs) OT - Muscle atrophy OT - Muscle wasting OT - Semaglutide OT - Tirzepatide COIS- Declaration of interests Dr. Roger S. McIntyre has received research grant support from CIHR, GACD, the National Natural Science Foundation of China (NSFC), and the Milken Institute. He has received speaker/consultation fees from Lundbeck, Janssen, Johnson & Johnson, Alkermes, Neumora Therapeutics, Boehringer Ingelheim, Bristol Myers Squibb, Sage, Mitsubishi Tanabe, Purdue, Pfizer, Otsuka, Takeda, MindMed, Neurocrine, Neurawell, Supernus, Bausch Health, Axsome, Novo Nordisk, Kris, Sanofi, Eisai, Intra-Cellular, NewBridge Pharmaceuticals, Viatris, AbbVie, and Atai Life Sciences. Angela T.H. Kwan and Moiz Lakhani declare no proprietary interests or conflicts of interest related to this submission. EDAT- 2026/03/22 06:06 MHDA- 2026/04/21 17:56 CRDT- 2026/03/21 19:12 PHST- 2025/12/10 00:00 [received] PHST- 2026/01/21 00:00 [revised] PHST- 2026/02/27 00:00 [accepted] PHST- 2026/04/21 17:56 [medline] PHST- 2026/03/22 06:06 [pubmed] PHST- 2026/03/21 19:12 [entrez] AID - S0261-5614(26)00047-6 [pii] AID - 10.1016/j.clnu.2026.106620 [doi] PST - ppublish SO - Clin Nutr. 2026 May;60:106620. doi: 10.1016/j.clnu.2026.106620. Epub 2026 Mar 4. PMID- 41862701 OWN - NLM STAT- MEDLINE DCOM- 20260722 LR - 20260722 IS - 1476-5497 (Electronic) IS - 0307-0565 (Linking) VI - 50 IP - 7 DP - 2026 Jul TI - A sequential deep learning model for predicting people with obesity in adults aged 18-64 using physical fitness variables. PG - 1451-1458 LID - 10.1038/s41366-026-02053-y [doi] AB - BACKGROUND/OBJECTIVES: Health of people with obesity is a global concern. We developed an explainable sequential deep learning model using nationally representative physical fitness data to predict people with obesity and to identify the most influential predictors. SUBJECTS/METHODS: We analyzed data from 204,334 adults collected between 2010 and 2023. A sequential neural network model was trained and evaluated using stratified 5-fold cross-validation. Model performance was assessed using accuracy, precision, recall, F1-score, and ROC-AUC, as well as MAE, MSE, and R(2). Explainability was examined using SHAP and LIME analyses to rank feature importance and interpret decision patterns. RESULTS: Across five stratified folds, the model achieved an overall accuracy of 0.87-0.88 (p < 0.001 vs. random). Fold 4 showed optimal performance (TN = 1,462; FN = 184; FP = 249; TP = 1,554), yielding an accuracy of 0.873 (precision = 0.866, recall = 0.855, F1 = 0.876, ROC-AUC = 0.95) and stabilizing at 20 epochs. For this model, MAE was 0.122, MSE was 0.041, and R(2) was 0.833, with an average prediction error of 0.171 for the first 50 samples. SHAP identified 20-m shuttle run estimated VO(2)max (importance = 0.339), gender (0.2481), and relative grip strength (0.135) as the top predictors. LIME (intercept = 0.511, predicted=0.668, R(2) = 0.995) indicated that low estimated VO(2)max ( < 28.71 ml/kg/min) and low relative grip strength ( < 38.17%) substantially increased the probability of obesity classification, particularly among females. CONCLUSIONS: This explainable sequential deep learning model accurately predicts people with obesity using physical fitness variables and highlights the critical role of cardiorespiratory fitness in obesity risk assessment and management. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Li, Xinxing AU - Li X AD - College of Wushu and Dance, Shenyang Sport University, Shenyang, China. FAU - Sung, Yunho AU - Sung Y AD - Health & Exercise Science Laboratory, Institute of Sports Science, Department of Physical Education, Seoul National University, Seoul, Republic of Korea. FAU - Zhang, Yanjie AU - Zhang Y AD - Physical Education Unit, School of Humanities and Social Science, The Chinese University of Hong Kong, Shenzhen, China. FAU - Lim, Byunggul AU - Lim B AD - Institute for Advancing Health Through Agriculture, Texas A&M University, College Station, TX, USA. FAU - Kim, Dae Young AU - Kim DY AD - Senior Exercise Rehabilitation Laboratory, Department of Gerokinesiology, Kyungil University, Gyeongsan, Republic of Korea. daeyoung@kiu.ac.kr. FAU - Bae, Jun-Hyun AU - Bae JH AUID- ORCID: 0000-0003-1918-9213 AD - Sports Omics Laboratory, Division of Sports Rehabilitation Medicine, Catholic Kwangdong University, Gangneung, Republic of Korea. junhyunb@cku.ac.kr. LA - eng PT - Journal Article DEP - 20260320 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 SB - IM MH - Humans MH - *Physical Fitness/physiology MH - *Deep Learning MH - Female MH - *Obesity/epidemiology/diagnosis/physiopathology MH - Adult MH - Male MH - Middle Aged MH - Adolescent MH - Predictive Learning Models MH - Young Adult MH - Prediction Algorithms COIS- Competing interests: The authors declare no competing interests. Ethics approval: Approval was obtained by the Research Ethics Committee of Seoul National University (approval no. E2007/003-006). The procedures used in this study adhere to the tenets of the Declaration of Helsinki. The studies were conducted in accordance with local legislation and institutional requirements. Written informed consent for participants was not required from the participants, their legal guardians, or next of kin in accordance with the national legislation and institutional requirements. The informed consent was waived. EDAT- 2026/03/21 06:30 MHDA- 2026/07/23 05:37 CRDT- 2026/03/21 00:26 PHST- 2025/11/06 00:00 [received] PHST- 2026/02/26 00:00 [accepted] PHST- 2026/02/02 00:00 [revised] PHST- 2026/07/23 05:37 [medline] PHST- 2026/03/21 06:30 [pubmed] PHST- 2026/03/21 00:26 [entrez] AID - 10.1038/s41366-026-02053-y [pii] AID - 10.1038/s41366-026-02053-y [doi] PST - ppublish SO - Int J Obes (Lond). 2026 Jul;50(7):1451-1458. doi: 10.1038/s41366-026-02053-y. Epub 2026 Mar 20. PMID- 41861073 OWN - NLM STAT- Publisher LR - 20260320 IS - 2047-4881 (Electronic) IS - 2047-4873 (Linking) DP - 2026 Mar 20 TI - Normative values for cardiopulmonary exercise testing in the pediatric population - an updated systematic review. LID - zwag168 [pii] LID - 10.1093/eurjpc/zwag168 [doi] AB - AIMS: Normative data for cardiopulmonary exercise testing (CPET) provide benchmarks of aerobic fitness that change throughout the lifespan, with new scaling techniques often developed and differing between adults and children/adolescents. Considering the recent interest in the pediatric population for CPET studies, this systematic review aimed to update pediatric-specific CPET reference values. METHODS AND RESULTS: A systematic review was performed according to the PRISMA guidelines from February 1, 2019, to December 31, 2025, from 6 scientific databases. Observational studies in any language, presenting data from maximal CPET, and conducted only on healthy participants <18 years old were included. Primary outcomes included reference values for peak oxygen uptake (V̇O2peak), and secondary outcomes included other variables assessed during CPET. Risk of bias was assessed with the 14-point ATS/ACCP statement for CPET and the 8-point JBI Critical Appraisal Tool. 15 studies conducted on 12,083 participants (5,886 [49.4%] females) were included, of which recruitment was hospital-based in 6 studies, community-based in 8 studies, and athlete-specific in 1 study. 6 studies reported ethnicity, with most participants classified as white, while 1 investigation presented exclusive data for obese/overweight or pediatric athletic cohorts. Normative V̇O2peak ranged between 26.0-56.3 mL.kg-1.min-1, peak heart rate between 175-199 bpm, and peak ventilation between 52.2-96.0 L.min-1. Reference equations were developed in 11 studies, with 5 of these studies validating the derived equations. A high heterogeneity was observed between studies of high- (n=2), moderate- (n=9), and low-quality (n=4), with ATS/ACCP statement and JBI Critical Appraisal Tool often disregarded - although quality level did not influence study outcomes. CONCLUSION: Updated normative values for CPET varied significantly in pediatric cohorts. While female representation matched male, and more studies considering pediatric athletes, showing a positive trend change from previous investigations, obese and overweight children/adolescents, as well as non-white participants, remained underrepresented. Considering the differences in normative data between pediatric cohorts of differing characteristics, clinicians should use reference values derived from cohorts closely matching their patients' characteristics. PROSPERO REGISTRATION NUMBER: CRD420251137402. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the European Society of Cardiology. FAU - Kasiak, Przemyslaw AU - Kasiak P AUID- ORCID: 0000-0002-0303-6135 AD - 3rd Department of Internal Medicine and Cardiology; Medical University of Warsaw, Warsaw, Poland. FAU - Kowalski, Tomasz AU - Kowalski T AUID- ORCID: 0000-0003-1333-1725 AD - Department of Physiology; Institute of Sport-National Research Institute, Warsaw, Poland. FAU - Zanini, Michele AU - Zanini M AUID- ORCID: 0009-0007-8148-8843 AD - School of Sport, Exercise, and Health Sciences; Loughborough University, Loughborough, UK. AD - School of Education, Childhood, Youth and Sport; The Open University, Milton Keynes, UK. FAU - Ozemek, Cemal AU - Ozemek C AUID- ORCID: 0000-0003-2644-215X AD - Department of Physical Therapy, College of Applied Health Sciences; University of Illinois Chicago, Chicago, Illinois, USA. FAU - Faiss, Raphael AU - Faiss R AUID- ORCID: 0000-0001-6029-9516 AD - Institute of Sports Sciences, Department of Physiology, Faculty of Biology and Medicine; University of Lausanne, Lausanne, Switzerland. FAU - Debevec, Tadej AU - Debevec T AUID- ORCID: 0000-0001-7053-3978 AD - Faculty of Sport; University of Ljubljana, Ljubljana, Slovenia. AD - Department of Automatics, Biocybernetics and Robotics; Jozef Stefan Institute, Ljubljana, Slovenia. FAU - Mamcarz, Artur AU - Mamcarz A AUID- ORCID: 0000-0002-9569-1486 AD - 3rd Department of Internal Medicine and Cardiology; Medical University of Warsaw, Warsaw, Poland. FAU - Sliz, Daniel AU - Sliz D AUID- ORCID: 0000-0001-5917-8119 AD - 3rd Department of Internal Medicine and Cardiology; Medical University of Warsaw, Warsaw, Poland. FAU - Chomiuk, Tomasz AU - Chomiuk T AUID- ORCID: 0000-0003-1341-327X AD - 3rd Department of Internal Medicine and Cardiology; Medical University of Warsaw, Warsaw, Poland. FAU - Ragazzoni, Gian Luca AU - Ragazzoni GL AUID- ORCID: 0000-0003-2915-0806 AD - Department of Medical Biotechnologies, Sports Cardiology and Rehab Unit, University of Siena, Siena, Italy. AD - Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London, UK. FAU - Arena, Ross AU - Arena R AUID- ORCID: 0000-0002-6675-1996 AD - Department of Physical Therapy, College of Applied Health Sciences; University of Illinois Chicago, Chicago, Illinois, USA. FAU - D'Ascenzi, Flavio AU - D'Ascenzi F AUID- ORCID: 0000-0002-0947-6836 AD - Department of Medical Biotechnologies, Sports Cardiology and Rehab Unit, University of Siena, Siena, Italy. FAU - Takken, Tim AU - Takken T AUID- ORCID: 0000-0002-7737-118X AD - Department of Medical Physiology, Child Development and Exercise Center, Wilhelmina Children's Hospital; University Medical Center Utrecht, Utrecht, the Netherlands. LA - eng PT - Journal Article DEP - 20260320 PL - England TA - Eur J Prev Cardiol JT - European journal of preventive cardiology JID - 101564430 SB - IM OAB - Cardiopulmonary exercise testing (CPET) have recently gained particular interest in the pediatric population, and updated CPET reference values and normalization techniques were systematically summarized and found to vary significantly between studies and children of different characteristics.Despite an equal representation of males and females as well as hospital- and community-based populations and ongoing advances in normative data for pediatric athletes, overweighted/obese children/adolescents, and non-white participants remain underrepresented in recent CPET research.Considering the differences in normative data between pediatric cohorts assessed, clinicians should use reference values derived from cohorts closely matching their patients characteristics. OABL- eng OTO - NOTNLM OT - CPET OT - Reference values OT - cardiopulmonary exercise testing OT - cardiorespiratory fitness OT - children OT - normative data OT - pediatric population EDAT- 2026/03/20 18:37 MHDA- 2026/03/20 18:37 CRDT- 2026/03/20 14:24 PHST- 2025/10/21 00:00 [received] PHST- 2026/01/05 00:00 [revised] PHST- 2026/03/20 18:37 [medline] PHST- 2026/03/20 18:37 [pubmed] PHST- 2026/03/20 14:24 [entrez] AID - 8530634 [pii] AID - 10.1093/eurjpc/zwag168 [doi] PST - aheadofprint SO - Eur J Prev Cardiol. 2026 Mar 20:zwag168. doi: 10.1093/eurjpc/zwag168. PMID- 41859877 OWN - NLM STAT- Publisher LR - 20260320 IS - 1469-8749 (Electronic) IS - 0012-1622 (Linking) DP - 2026 Mar 20 TI - Environmental supportiveness, physical activity, and sedentary time in children with cerebral palsy. LID - 10.1111/dmcn.70253 [doi] AB - AIM: To describe how movement behaviours (sedentary time, light-intensity physical activity, moderate-to-vigorous physical activity [MVPA]) and parent-reported community physical activity participation vary across levels of environmental supportiveness (home, school, community) in children with cerebral palsy (CP). METHOD: This was a secondary cross-sectional observational study using pooled data (n = 141) from four studies of children with CP aged 6 to 16 years (mean = 10 years 1 month [SD = 2 years 5 months]; Gross Motor Function Classification System level I = 71, level II = 41, levels III-IV = 29). Children wore hip-mounted triaxial accelerometers; validated machine-learning models classified sedentary time, light physical activity, and MVPA. Parents reported community physical activity participation and environmental supportiveness using the Participation and Environment Measure for Children and Youth. Linear models were adjusted for wear time and study. We estimated marginal mean differences (MMDs) in time spent in movement behaviours between the 25th and 75th centiles of supportiveness scores. RESULTS: Greater community (MMD = -30.1 minutes, 95% confidence interval [CI] = -53.4 to -8.1), home (-31.4 min, 95% CI = -51.5 to -11.3), and school (MMD = -54.1 min, 95% CI = -76.0 to -32.2) supportiveness were associated with less sedentary time. Higher home supportiveness was associated with more time in light physical activity (MMD = 23.7 minutes, 95% CI = 11.0 to 36.3), whereas school and community supportiveness were not associated with light physical activity. No environmental supportiveness measures were associated with time in MVPA. INTERPRETATION: Greater environmental supportiveness across all contexts was associated with lower sedentary time, while greater home supportiveness was associated with more time in light physical activity. Other factors may have stronger associations with MVPA time. CI - (c) 2026 The Author(s). Developmental Medicine & Child Neurology published by John Wiley & Sons Ltd on behalf of Mac Keith Press. FAU - Oftedal, Stina AU - Oftedal S AUID- ORCID: 0000-0002-6769-1454 AD - Queensland Cerebral Palsy and Rehabilitation Research Centre, University of Queensland, Brisbane, Queensland, Australia. FAU - Armstrong, Ellen AU - Armstrong E AD - Queensland Cerebral Palsy and Rehabilitation Research Centre, University of Queensland, Brisbane, Queensland, Australia. FAU - Kilgour, Gaela AU - Kilgour G AUID- ORCID: 0000-0002-8867-7782 AD - Queensland Cerebral Palsy and Rehabilitation Research Centre, University of Queensland, Brisbane, Queensland, Australia. FAU - Ahmadi, Matthew AU - Ahmadi M AD - School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia. FAU - Trost, Stewart G AU - Trost SG AD - School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, Queensland, Australia. FAU - Horan, Sean A AU - Horan SA AD - Menzies Health Institute Queensland and School of Allied Health Sciences, Griffith University, Queensland, Australia. FAU - Carty, Christopher AU - Carty C AD - School of Allied Health Sciences and Gold Coast Orthopaedic Research Engineering and Education Alliance, Menzies Health Institute Queensland, Griffith University, Queensland, Australia. FAU - Brookes, Denise AU - Brookes D AD - School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, Queensland, Australia. FAU - Boyd, Roslyn N AU - Boyd RN AUID- ORCID: 0000-0002-4919-5975 AD - Queensland Cerebral Palsy and Rehabilitation Research Centre, University of Queensland, Brisbane, Queensland, Australia. FAU - Sakzewski, Leanne AU - Sakzewski L AUID- ORCID: 0000-0001-5395-544X AD - Queensland Cerebral Palsy and Rehabilitation Research Centre, University of Queensland, Brisbane, Queensland, Australia. FAU - Reedman, Sarah E AU - Reedman SE AUID- ORCID: 0000-0002-3937-5649 AD - Queensland Cerebral Palsy and Rehabilitation Research Centre, University of Queensland, Brisbane, Queensland, Australia. LA - eng GR - Merchant Charitable Foundation donation ID 10415/Children's Hospital Foundation/ GR - 1077257/National Health and Medical Research Council/ GR - 1140756/National Health and Medical Research Council/ GR - PG3915/Cerebral Palsy Alliance Research Foundation/ PT - Journal Article DEP - 20260320 PL - England TA - Dev Med Child Neurol JT - Developmental medicine and child neurology JID - 0006761 SB - IM EDAT- 2026/03/20 07:10 MHDA- 2026/03/20 07:10 CRDT- 2026/03/20 05:43 PHST- 2026/02/16 00:00 [revised] PHST- 2025/03/02 00:00 [received] PHST- 2026/02/18 00:00 [accepted] PHST- 2026/03/20 07:10 [medline] PHST- 2026/03/20 07:10 [pubmed] PHST- 2026/03/20 05:43 [entrez] AID - 10.1111/dmcn.70253 [doi] PST - aheadofprint SO - Dev Med Child Neurol. 2026 Mar 20. doi: 10.1111/dmcn.70253. PMID- 41859786 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260820 IS - 1601-6343 (Electronic) IS - 1601-6335 (Print) IS - 1601-6335 (Linking) VI - 29 IP - 4 DP - 2026 Aug TI - 3D Gaussian Splatting vs. 2D Photogrammetry and Direct Anthropometry for Facial Measurements. PG - 688-697 LID - 10.1111/ocr.70116 [doi] AB - BACKGROUND: This study evaluates the accuracy and repeatability of 3D Gaussian Splatting (3DGS)-generated 3D facial models by comparing anthropometric measurements derived from these models with those obtained using conventional 2D photogrammetry and direct anthropometry. METHODS: In this cross-sectional study, 58 adults (18-25 years) underwent direct anthropometry, standardised 2D photography with calibration, and 3DGS facial reconstruction using a smartphone-based workflow. A predefined set of linear and angular facial measurements was recorded; each measurement was repeated three times by the same observer. Between-method comparisons were performed using paired tests as appropriate. Pearson correlation coefficients were reported to describe association, whereas agreement and potential interchangeability were evaluated primarily using Bland-Altman bias and 95% limits of agreement (LoA); plots were additionally inspected for proportional bias and influential outliers. RESULTS: 3DGS demonstrated small mean differences relative to direct anthropometry for several measurements, with generally narrower LoA than 2D photogrammetry. Correlations were typically higher for 3DGS than for 2D photogrammetry; however, Bland-Altman analyses indicated that agreement varied by variable. For selected measurements, LoA were wide (reaching approximately 10-18 mm for some linear outcomes and exceeding 20 degrees for certain angular outcomes), indicating limited interchangeability for individual-level clinical decisions. Perioral measures showed greater dispersion for 2D photogrammetry, particularly for N-Stm, and a small number of observations fell outside the 95% LoA in ANT vs. 2D comparisons, consistent with occasional landmark identification or reconstruction-related variability. CONCLUSION: 3D Gaussian Splatting (3DGS) may offer a useful alternative workflow for selected facial analysis applications by enabling the generation of measurable three-dimensional facial models, from which anthropometric variables can subsequently be derived. Although 2D photogrammetry is readily accessible and practical to implement, its inherent limitation in representing three-dimensional anatomy may compromise measurement accuracy in certain clinical contexts. Overall, these findings indicate that 3DGS could support orthodontic practice and research as a 3D model-generation technique; however, further validation across diverse patient groups, acquisition conditions, expanded landmark-based geometric error metrics, and additional outcome measures is warranted before routine clinical adoption can be recommended. CI - (c) 2026 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. FAU - Genc, Celal AU - Genc C AD - Department of Orthodontics, Faculty of Dentistry, Canakkale Onsekiz Mart University, Canakkale, Turkiye. FAU - Arisan, Arda AU - Arisan A AUID- ORCID: 0009-0004-8920-8605 AD - Private Practice, Ankara, Turkiye. FAU - Toprak, Mert AU - Toprak M AUID- ORCID: 0009-0003-4698-4586 AD - Department of Orthodontics, Faculty of Dentistry, Canakkale Onsekiz Mart University, Canakkale, Turkiye. FAU - Duran, Gokhan Serhat AU - Duran GS AUID- ORCID: 0000-0001-6152-6178 AD - Department of Orthodontics, Faculty of Dentistry, Canakkale Onsekiz Mart University, Canakkale, Turkiye. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260320 PL - England TA - Orthod Craniofac Res JT - Orthodontics & craniofacial research JID - 101144387 SB - IM MH - Humans MH - *Photogrammetry/methods/statistics & numerical data MH - *Imaging, Three-Dimensional/methods/statistics & numerical data MH - *Face/anatomy & histology/diagnostic imaging MH - Cross-Sectional Studies MH - Young Adult MH - Reproducibility of Results MH - Adolescent MH - Adult MH - Female MH - Male MH - Normal Distribution MH - Image Processing, Computer-Assisted/methods/statistics & numerical data MH - *Anthropometry/methods MH - Photography MH - Smartphone MH - Cephalometry/methods/statistics & numerical data MH - Calibration PMC - PMC13485164 OTO - NOTNLM OT - 3D gaussian splatting OT - digital imaging OT - facial anthropometry OT - measurement accuracy OT - orthodontic diagnosis COIS- The authors declare no conflicts of interest. EDAT- 2026/03/20 07:10 MHDA- 2026/08/18 17:37 PMCR- 2026/08/18 CRDT- 2026/03/20 05:02 PHST- 2026/01/28 00:00 [revised] PHST- 2025/10/17 00:00 [received] PHST- 2026/03/06 00:00 [accepted] PHST- 2026/08/18 17:37 [medline] PHST- 2026/03/20 07:10 [pubmed] PHST- 2026/03/20 05:02 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - OCR70116 [pii] AID - 10.1111/ocr.70116 [doi] PST - ppublish SO - Orthod Craniofac Res. 2026 Aug;29(4):688-697. doi: 10.1111/ocr.70116. Epub 2026 Mar 20. PMID- 41859655 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260320 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Key dietary amino acids modulating overweight/obesity risk in Chinese children and adolescents: a machine learning analysis of a national survey. PG - 1769111 LID - 10.3389/fnut.2026.1769111 [doi] LID - 1769111 AB - OBJECTIVE: To mitigate current research limitations, this cross-sectional study aimed to systematically evaluate the associations between dietary amino acids and overweight/obesity and to identify critical biomarkers among Chinese children and adolescents. This was achieved by integrating multiple machine learning algorithms with traditional statistical models. METHODS: This study utilized data from the 2016-2019 China Children and Lactating Women Nutrition and Health Surveillance, a nationally representative survey. Participants included children and adolescents aged 6-18 years. Dietary intake was assessed using a validated food frequency questionnaire, and amino acid intakes were calculated. Four machine learning algorithms were applied to build prediction models. Model performance was evaluated via the area under the receiver operating characteristic curve (AUC). The SHapley Additive exPlanations (SHAP) method was used to interpret the optimal model and identify important features. Multivariable logistic regression models were additionally used to examine the relationship between amino acids and overweight/obesity risk. RESULTS: A total of 8,664 participants were included. The LightGBM model showed the best predictive effect (AUC = 0.805). Both SHAP analysis and logistic regression results consistently identified leucine (OR 1.13; 95% CI 1.01 ~ 1.27), threonine (OR 1.41; 95% CI 1.22 ~ 1.63), methionine (OR 1.30; 95% CI 1.07 ~ 1.57), and cysteine (OR 0.71; 95% CI 0.59 ~ 0.84) as key amino acids associated with overweight/obesity risk. After multivariable adjustment, the intake of leucine, threonine, and methionine was positively related to the risk of overweight/obesity, whereas cysteine intake was inversely related to the risk. Restricted cubic spline analyses suggested linear relationships for these associations. CONCLUSION: Higher dietary intakes of leucine, threonine, and methionine are potential risk factors, while cysteine is a potential protective factor against overweight/obesity in Chinese children and adolescents. CI - Copyright (c) 2026 Liu, Li, Zhang, Liu, Liu, Tian, Zhu, Chen, Yu and Wang. FAU - Liu, Qiangqiang AU - Liu Q AD - Department of Internal Medicine, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, China. FAU - Li, Cheng AU - Li C AD - Department of Clinical Nutrition, Beijing Friendship Hospital, Capital Medical University, Beijing, China. FAU - Zhang, Yifan AU - Zhang Y AD - School of Public Health, Southern Medical University, Guangzhou, China. FAU - Liu, Changqing AU - Liu C AD - Hebei Center for Disease Control and Prevention, Shijiazhuang, China. FAU - Liu, Yiya AU - Liu Y AD - Guizhou Center for Disease Control and Prevention, Guiyang, China. FAU - Tian, Meina AU - Tian M AD - Hebei Center for Disease Control and Prevention, Shijiazhuang, China. FAU - Zhu, Qianrang AU - Zhu Q AD - Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China. FAU - Chen, Yao AU - Chen Y AD - Clinical Nutrition Department, People's Hospital of Rizhao, Rizhao, China. FAU - Yu, Lianlong AU - Yu L AD - Shandong Center for Disease Control and Prevention, Jinan, China. FAU - Wang, Hongwei AU - Wang H AD - Department of Health Care, People's Hospital of Rizhao, Rizhao, China. LA - eng PT - Journal Article DEP - 20260304 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12995779 OTO - NOTNLM OT - adolescents OT - children OT - dietary amino acids OT - machine learning OT - obesity OT - overweight COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/20 07:10 MHDA- 2026/03/20 07:11 PMCR- 2026/03/04 CRDT- 2026/03/20 04:56 PHST- 2025/12/16 00:00 [received] PHST- 2026/01/20 00:00 [revised] PHST- 2026/02/19 00:00 [accepted] PHST- 2026/03/20 07:11 [medline] PHST- 2026/03/20 07:10 [pubmed] PHST- 2026/03/20 04:56 [entrez] PHST- 2026/03/04 00:00 [pmc-release] AID - 10.3389/fnut.2026.1769111 [doi] PST - epublish SO - Front Nutr. 2026 Mar 4;13:1769111. doi: 10.3389/fnut.2026.1769111. eCollection 2026. PMID- 41857684 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Mar 19 TI - Integrating physical, emotional, and social changes to examine their associations with self-efficacy among college students engaging in physical activity. LID - 10.1186/s40359-026-04255-5 [doi] LID - 616 AB - INTRODUCTION: College students face increasing physical and psychological challenges, and the multidimensional association between physical activity and well-being warrants clarification. This study tested an integrative model linking physical activity to perceived physical, emotional, and social relationship changes and self-efficacy, and examined variation by sex and training time. METHODS: A cross-sectional survey was conducted among 1,082 full-time university students in China (inclusion: basic engagement in physical activity; exclusion: major physical or mental illness). Validated questionnaires were used to assess physical activity, self-efficacy, health status, and well-being, together with study-developed subscales for perceived physical, emotional, and social relationship changes. Internal consistency and construct validity were evaluated in the study sample, and the intended measurement structure was supported. Correlation analyses and structural equation modelling (SPSS/AMOS) examined model-based associations and moderation by sex and training time. This study was approved by the institutional ethics committee, and informed consent was obtained from all participants. RESULTS: Perceived physical, emotional, and social relationship changes were positively associated with self-efficacy; perceived emotional changes correlated strongly with perceived physical changes (r = 0.843, p < 0.01). In structural equation modelling, perceived emotional changes were positioned between perceived physical changes and downstream social relationship changes and self-efficacy, consistent with an indirect association pattern. Sex differences were observed for social relationship changes and self-efficacy, and training time moderated selected paths. CONCLUSION: Physical activity-related variables were associated with an interconnected physical-emotional-social pattern linked to self-efficacy, with variation by sex and training time. These findings should be interpreted as model-based associations; longitudinal or experimental studies are needed to establish temporal ordering and causal mechanisms. FAU - Zhang, Xiaomei AU - Zhang X AD - School of Humanities and Social Sciences, Fuzhou University, Fuzhou, 350116, Fujian, China. FAU - Wei, Yaming AU - Wei Y AD - Research Center for Arts and health, Xiamen Humanity Hospital, Xiamen, 361000, Fujian, China. FAU - Song, Yongfan AU - Song Y AD - Department of Physical Education Research, Fuzhou University, No. 2, Wulongjiang North Avenue, Fuzhou, 350116, Fujian, China. t11090@fzu.edu.cn. LA - eng PT - Journal Article DEP - 20260319 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - *Self Efficacy MH - Male MH - Female MH - *Students/psychology MH - Cross-Sectional Studies MH - *Exercise/psychology MH - Universities MH - Young Adult MH - China MH - *Emotions MH - Adult MH - *Interpersonal Relations MH - Adolescent MH - Surveys and Questionnaires MH - Sex Factors MH - Health Status MH - Psychological Well-Being PMC - PMC13123179 OTO - NOTNLM OT - Emotion regulation OT - Exercise duration OT - Physical Activity OT - Self-Efficacy OT - Sex differences OT - Social relationships COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Clinical Ethics Committee of Fuzhou University and was conducted in accordance with the Declaration of Helsinki. This study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki. The research protocol was reviewed and approved by the Clinical Ethics Committee of Fuzhou University. The study posed minimal risk to participants, and all data were collected anonymously to protect participant privacy. All participants provided informed consent prior to their inclusion in the study. They were informed of the study's purpose, procedures, and their right to withdraw at any time without consequence. Consent was obtained voluntarily from each participant, and no incentives were provided that could influence participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/20 07:10 MHDA- 2026/06/27 12:38 PMCR- 2026/03/19 CRDT- 2026/03/20 00:40 PHST- 2025/03/22 00:00 [received] PHST- 2026/02/24 00:00 [accepted] PHST- 2026/06/27 12:38 [medline] PHST- 2026/03/20 07:10 [pubmed] PHST- 2026/03/20 00:40 [entrez] PHST- 2026/03/19 00:00 [pmc-release] AID - 10.1186/s40359-026-04255-5 [pii] AID - 4255 [pii] AID - 10.1186/s40359-026-04255-5 [doi] PST - epublish SO - BMC Psychol. 2026 Mar 19;14(1):616. doi: 10.1186/s40359-026-04255-5. PMID- 41857417 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260920 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 4 DP - 2026 Mar 20 TI - Understanding the impact of growth hormone on ventilatory control stability in children with Prader-Willi syndrome. LID - 10.1007/s00431-026-06857-y [doi] LID - 194 AB - A hallmark of Prader-Willi syndrome (PWS) is hypothalamic-pituitary axis dysfunction, which can result in reduced growth hormone (GH) production. While GH replacement therapy is common in children with PWS, it has also been implicated in the development of obstructive sleep apnoea (OSA) in some children. The mechanisms underlying this development are poorly understood but may be related to alterations in ventilatory control. Our study investigated the impact of GH treatment on ventilatory control stability during sleep in children with PWS. Polysomnographic data pre- and post-GH therapy in 25 children (aged 2mo-18y) were used to assess ventilatory control using a validated method that estimates loop gain (dimensionless ratio) from ventilation changes following spontaneous sighs during sleep. Data were analysed using linear mixed-effects modelling with GH as a fixed effect and participant as a random intercept. Covariates that could impact loop gain including age, obstructive-apnoea hypopnoea index (OAHI) and central apnoea-hypopnoea index (CAHI) were each added separately to the base model in a stepwise, manual forward selection approach. Loop gain was not altered by GH treatment (beta = 0.003, 95% CI: [-0.042, 0.049], p = 0.878, Cohen's d = 0.031). Age, OAHI and CAHI did not alter the impact of GH on loop gain. No difference in sleep or respiratory characteristics were found, however 20% of children developed OSA post-GH. CONCLUSION: Initiation of GH therapy was not associated with a change in loop gain, suggesting that changes in ventilatory control are unlikely to contribute to the development of OSA in children with PWS. WHAT IS KNOWN: * Prader-Willi syndrome is associated with abnormal ventilatory control and increased risk of sleep-disordered breathing. * Growth hormone therapy may influence respiratory physiology but its effect on the stability of ventilatory control (loop gain) remains unclear. WHAT IS NEW: * In this cohort of children with Prader-Willi syndrome, growth hormone therapy did not alter loop gain despite inter-individual variability. * Our findings suggest that any sleep-disordered breathing that emerges following growth hormone therapy is likely driven by mechanisms other than altered loop gain. CI - (c) 2026. The Author(s). FAU - Patoglu, Okkes R AU - Patoglu OR AD - Department of Paediatrics, Monash University, Melbourne, VIC, Australia. FAU - Horne, Rosemary S C AU - Horne RSC AD - Department of Paediatrics, Monash University, Melbourne, VIC, Australia. FAU - Mann, Dwayne L AU - Mann DL AD - School of Electrical Engineering and Computer Science, The University of Queensland, Brisbane, QLD, Australia. FAU - Landry, Shane A AU - Landry SA AD - School of Psychological Sciences, Monash University, Melbourne, VIC, Australia. FAU - Kapur, Nitin AU - Kapur N AD - Department of Paediatric Respiratory and Sleep Medicine, Queensland Children's Hospital, Brisbane, QLD, Australia. AD - Children's Health Queensland Clinical Unit, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia. FAU - Thambar, Samara AU - Thambar S AD - Department of Paediatric Respiratory and Sleep Medicine, Queensland Children's Hospital, Brisbane, QLD, Australia. FAU - Robinson, Jacob AU - Robinson J AD - Department of Paediatric Respiratory and Sleep Medicine, Queensland Children's Hospital, Brisbane, QLD, Australia. FAU - Davey, Margot J AU - Davey MJ AD - Department of Paediatrics, Monash University, Melbourne, VIC, Australia. AD - Melbourne Children's Sleep Centre, Monash Children's Hospital, Melbourne, VIC, Australia. FAU - Nixon, Gillian M AU - Nixon GM AD - Department of Paediatrics, Monash University, Melbourne, VIC, Australia. AD - Melbourne Children's Sleep Centre, Monash Children's Hospital, Melbourne, VIC, Australia. FAU - Edwards, Bradley A AU - Edwards BA AD - School of Psychological Sciences, Monash University, Melbourne, VIC, Australia. Bradley.Edwards@monash.edu. LA - eng PT - Journal Article DEP - 20260320 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 12629-01-5 (Human Growth Hormone) SB - IM MH - Humans MH - *Prader-Willi Syndrome/drug therapy/physiopathology/complications MH - Polysomnography MH - *Sleep Apnea, Obstructive/etiology/chemically induced/physiopathology MH - Child, Preschool MH - Child MH - *Human Growth Hormone/therapeutic use/adverse effects MH - Female MH - Male MH - Adolescent MH - Infant PMC - PMC13002677 OTO - NOTNLM OT - Loop gain OT - Paediatric OT - Prader-Willi syndrome OT - Sleep OT - Ventilatory control COIS- Declarations. Competing interests: Associate Professor Edwards has received grant funding from Apnimed, Myofunctional Research Company, Fisher and Paykall and Incannex as well as personal fees from EQT Partners outside the current work. All other authors have no conflicts of interest to declare. EDAT- 2026/03/20 07:10 MHDA- 2026/03/20 07:11 PMCR- 2026/03/20 CRDT- 2026/03/20 00:28 PHST- 2025/12/13 00:00 [received] PHST- 2026/03/10 00:00 [accepted] PHST- 2026/02/20 00:00 [revised] PHST- 2026/03/20 07:11 [medline] PHST- 2026/03/20 07:10 [pubmed] PHST- 2026/03/20 00:28 [entrez] PHST- 2026/03/20 00:00 [pmc-release] AID - 10.1007/s00431-026-06857-y [pii] AID - 6857 [pii] AID - 10.1007/s00431-026-06857-y [doi] PST - epublish SO - Eur J Pediatr. 2026 Mar 20;185(4):194. doi: 10.1007/s00431-026-06857-y. PMID- 41855641 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260711 IS - 1872-7123 (Electronic) IS - 0165-1781 (Linking) VI - 360 DP - 2026 Jun TI - Longitudinal associations among childhood trauma, oxytocin, and metabolic risk in schizophrenia. PG - 117088 LID - S0165-1781(26)00149-6 [pii] LID - 10.1016/j.psychres.2026.117088 [doi] AB - Childhood trauma has been consistently associated with adverse physical and metabolic outcomes in schizophrenia, yet the neurobiological mechanisms translating early-life adversity into long-term metabolic risk remain unclear. Oxytocin, a stress-sensitive neuropeptide involved in metabolic regulation, may modulate stress-related metabolic vulnerability. In this 24-month prospective cohort study, 90 individuals with schizophrenia receiving stable antipsychotic monotherapy and 60 age- and sex-matched healthy controls underwent assessments of anthropometric measures, metabolic parameters, and plasma oxytocin levels at baseline and follow-up. Metabolic outcomes included Continuous Metabolic Syndrome Severity Scores (cMetS-S) and metabolic syndrome (MetS) incidence, while childhood trauma was assessed using the Childhood Trauma Questionnaire-Short Form with cross-validation interviews. Generalized estimating equations were applied to evaluate longitudinal associations, and moderation analyses tested oxytocin x childhood trauma interactions. Greater childhood trauma exposure was associated with lower plasma oxytocin levels (p = .001), higher body mass index (p < .001), and greater metabolic burden over time (p = .009). At 24-month follow-up, individuals with schizophrenia exhibited higher MetS incidence (p = .043) and higher cMetS-S (p = .006) compared with healthy controls.Lower oxytocin levels predicted increased MetS risk (OR = 0.27, p = .009). Importantly, a significant childhood trauma x oxytocin interaction (OR = 0.95, p = .018) indicated that higher oxytocin levels attenuated trauma-related metabolic deterioration. These findings suggest that oxytocinergic dysregulation may be involved in the association between early-life trauma and metabolic risk in schizophrenia and support oxytocin as a candidate biomarker associated with trauma-related metabolic vulnerability. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Goh, Kah Kheng AU - Goh KK AD - Department of Psychiatry, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei, Taiwan; Graduate School of Criminology, National Taipei University, Taipei, Taiwan. FAU - Chen, Po-Yu AU - Chen PY AD - Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry, Taipei City Psychiatry Center, Taipei, Taiwan. FAU - Chang, Hu-Ming AU - Chang HM AD - Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry, Taipei City Psychiatry Center, Taipei, Taiwan. FAU - Kanahara, Nobuhisa AU - Kanahara N AD - Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan. FAU - Chen, Chenyi AU - Chen C AD - Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei, Taiwan; Research Center for Mind, Brain & Learning, National Chengchi University, Taipei, Taiwan. FAU - Cheng, Ming-Hui AU - Cheng MH AD - Department of Psychology, National Cheng Kung University, Tainan, Taiwan. FAU - Yang, Cheng-Ta AU - Yang CT AD - Department of Psychology, National Cheng Kung University, Tainan, Taiwan; Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan. FAU - Lu, Mong-Liang AU - Lu ML AD - Department of Psychiatry, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: mongliang@hotmail.com. LA - eng PT - Journal Article DEP - 20260310 PL - Ireland TA - Psychiatry Res JT - Psychiatry research JID - 7911385 RN - 50-56-6 (Oxytocin) SB - IM MH - Humans MH - *Oxytocin/blood MH - Female MH - *Schizophrenia/blood/epidemiology/metabolism/complications MH - Male MH - *Metabolic Syndrome/epidemiology/blood MH - Longitudinal Studies MH - Adult MH - *Adverse Childhood Experiences MH - Prospective Studies OTO - NOTNLM OT - Body mass index OT - Childhood trauma OT - Metabolic syndrome OT - Oxytocin OT - Schizophrenia COIS- Declaration of competing interest All authors have no conflict of interest to report. EDAT- 2026/03/20 00:59 MHDA- 2026/04/07 00:31 CRDT- 2026/03/19 19:02 PHST- 2025/12/31 00:00 [received] PHST- 2026/03/06 00:00 [revised] PHST- 2026/03/10 00:00 [accepted] PHST- 2026/04/07 00:31 [medline] PHST- 2026/03/20 00:59 [pubmed] PHST- 2026/03/19 19:02 [entrez] AID - S0165-1781(26)00149-6 [pii] AID - 10.1016/j.psychres.2026.117088 [doi] PST - ppublish SO - Psychiatry Res. 2026 Jun;360:117088. doi: 10.1016/j.psychres.2026.117088. Epub 2026 Mar 10. PMID- 41854913 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 1432-0711 (Electronic) IS - 0932-0067 (Print) IS - 0932-0067 (Linking) VI - 313 IP - 1 DP - 2026 Mar 19 TI - Aortic isthmus Doppler hemodynamics and impacts on perinatal outcomes in pregestational and gestational diabetes mellitus. LID - 10.1007/s00404-026-08378-3 [doi] LID - 133 AB - BACKGROUND/AIM: To assess the sensitivity of the fetal aortic isthmus (AoI) Doppler changes in predicting the adverse perinatal outcome with pregestational and gestational diabetes mellitus compared with other Doppler parameters. MATERIALS AND METHODS: This prospective case-control study was undertaken between Agust 2023 and May 2024 in Ankara Etlik City Hospital perinatology department. Maternal age, gravidity, parity, maternal body mass index (BMI), gestational age at ultrasonographic examination, fetal AoI, umbilical artery (UA), middle cerebral artery (MCA), and uterine artery (UtA) Doppler parameters were compared between four groups: Pregestational diabetes mellitus (PGDM) (n = 30), diet-regulated gestational diabetes mellitus (DRGDM) (n = 30), insulin-regulated GDM (IRGDM) (n = 30), and controls (n = 75). HbA1c values were evaluated only in pregnancies complicated by diabetes mellitus. The composite adverse perinatal outcomes (CAPO) was defined as Apgar score at 5 min < 7, cord blood pH < 7, sepsis, phototherapy for neonates, respiratory distress syndrome (RDS), mechanical ventilation, neonatal intensive care unit (NICU) admission, hypoglycemia. RESULTS: Maternal age and BMI levels were significantly higher in the PGDM group (p < 0.001). HbA1c levels were significantly higher in the PGDM group compared to other diabetic groups (p < 0.001). While most Doppler parameters were similar across groups, PGDM cases had higher rates of prematurity (40%), cesarean delivery (90%), NICU admission (60%), and CAPO (63.3%) compared to controls (p < 0.01 for all). HbA1c was positively correlated with MCA S/D, AoI-PSV, and AoI S/D (p < 0.05). ROC analysis showed that AoI Ta-max and EDV had modest predictive value for CAPO (AUC = 0.627 and 0.638, respectively; p < 0.05). CONCLUSIONS: The AoI Doppler flow measurements may serve as a potential adjunctive marker in the assessment of adverse perinatal outcomes in pregnancies complicated by diabetes mellitus. However, further large-scale prospective studies are warranted to validate its clinical applicability and establish its role in routine obstetric practice. CI - (c) 2026. The Author(s). FAU - Seyhanli, Zeynep AU - Seyhanli Z AUID- ORCID: 0000-0003-3924-3723 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. drzeynepseyhanli@gmail.com. FAU - Karabay, Gulsan AU - Karabay G AUID- ORCID: 0000-0003-2567-2850 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Filiz, Ahmet Arif AU - Filiz AA AUID- ORCID: 0000-0002-6137-0270 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Duygulu Bulan, Dilara AU - Duygulu Bulan D AUID- ORCID: 0000-0001-9983-2306 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Agaoglu, Recep Taha AU - Agaoglu RT AUID- ORCID: 0000-0002-6570-1006 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Aktemur, Gizem AU - Aktemur G AUID- ORCID: 0000-0001-6824-881X AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Cakir, Betul Tokgoz AU - Cakir BT AUID- ORCID: 0000-0003-0202-4981 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Yucel, Kadriye Yakut AU - Yucel KY AUID- ORCID: 0000-0003-3182-4312 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Yilmaz, Zehra Vural AU - Yilmaz ZV AUID- ORCID: 0000-0002-8719-1879 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20260319 PL - Germany TA - Arch Gynecol Obstet JT - Archives of gynecology and obstetrics JID - 8710213 SB - IM MH - Humans MH - Pregnancy MH - Female MH - *Diabetes, Gestational/physiopathology/diagnostic imaging MH - Case-Control Studies MH - Prospective Studies MH - *Ultrasonography, Prenatal/methods MH - Pregnancy Outcome MH - Ultrasonography, Doppler MH - Umbilical Arteries/diagnostic imaging MH - Adult MH - Uterine Artery/diagnostic imaging MH - *Aorta, Thoracic/diagnostic imaging/physiopathology/embryology MH - Middle Cerebral Artery/diagnostic imaging MH - Hemodynamics MH - Infant, Newborn MH - *Pregnancy in Diabetics/physiopathology PMC - PMC13002718 OTO - NOTNLM OT - Aortic isthmus OT - Composite adverse perinatal outcomes OT - Doppler OT - Gestational diabetes mellitus COIS- Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: Written informed consent was obtained from all participants prior to their enrollment in the study. The research was conducted in adherence to the guidelines outlined in the Declaration of Helsinki. The Ethics Committee of Ankara Etlik City Hospital granted approval (Number: AESH-EK1-2023-358). EDAT- 2026/03/19 21:44 MHDA- 2026/03/19 21:45 PMCR- 2026/03/19 CRDT- 2026/03/19 12:15 PHST- 2025/11/19 00:00 [received] PHST- 2026/02/24 00:00 [accepted] PHST- 2026/03/19 21:45 [medline] PHST- 2026/03/19 21:44 [pubmed] PHST- 2026/03/19 12:15 [entrez] PHST- 2026/03/19 00:00 [pmc-release] AID - 10.1007/s00404-026-08378-3 [pii] AID - 8378 [pii] AID - 10.1007/s00404-026-08378-3 [doi] PST - epublish SO - Arch Gynecol Obstet. 2026 Mar 19;313(1):133. doi: 10.1007/s00404-026-08378-3. PMID- 41852676 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260319 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Nutrition literacy among primary school students in Nanshan District, Shenzhen: current status and influencing factors. PG - 1775403 LID - 10.3389/fnut.2026.1775403 [doi] LID - 1775403 AB - OBJECTIVE: Nutrition literacy is critical for establishing healthy dietary behaviors during childhood, yet research on this topic among primary school students in rapidly urbanizing China remains limited. The aim of this large-scale survey is to assess the current status and identify key influencing factors of nutrition literacy among primary school students in Nanshan District, Shenzhen City. METHODS: A cross-sectional survey was conducted in October 2024 utilizing a cluster random sampling method. A total of 2,423 students from 21 public primary schools participated. Data were collected using the validated "Nutrition Literacy and Dietary Behavior Questionnaire for School-aged Children", which evaluated four dimensions: nutrition knowledge and concepts, food selection, food preparation, and food intake. Statistical analyses included descriptive statistics, correlation analysis, and binary logistic regression. RESULTS: Participants achieved a mean total nutrition literacy score of 69.93 +/- 8.75, with 30.38% meeting the criterion for adequate nutrition literacy (score >/=75). Interdimensional analysis revealed statistically significant positive correlations among all four domains (r = 0.198 ~ 0.363, p < 0.001). Multivariable logistic regression identified grade level-representing individual-level factors (Grade 5 vs. Grade 3 OR = 0.626, 95% CI: 0.500-0.783), high household economic status-family-level factors (OR = 1.389, 95% CI: 1.139-1.649), and participation in school activities including nutrition-related activities (OR = 1.346, 95% CI: 1.125-1.611) and regular weight monitoring (OR = 1.346, 95% CI: 1.125-1.611) as key predictors of adequate nutrition literacy. CONCLUSION: Nutrition literacy among primary school students in Nanshan District requires substantial improvement and is influenced by factors at individual, familial, and institutional levels. These findings suggest the necessity of developing a comprehensive, student-centered intervention model that integrates family-school collaboration to effectively enhance nutritional literacy. CI - Copyright (c) 2026 Yang, Li, Zhang, Li, Zheng and Zhu. FAU - Yang, Jing AU - Yang J AD - Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China. FAU - Li, Nana AU - Li N AD - School of Public Health, Zunyi Medical University, Zunyi, China. FAU - Zhang, Ti AU - Zhang T AD - Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China. FAU - Li, Xiaoyue AU - Li X AD - Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China. FAU - Zheng, Liuyuan AU - Zheng L AD - Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China. FAU - Zhu, Minmin AU - Zhu M AD - Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China. LA - eng PT - Journal Article DEP - 20260303 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12992053 OTO - NOTNLM OT - Shenzhen OT - health literacy OT - influencing factors OT - nutrition literacy OT - primary school students COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/19 07:10 MHDA- 2026/03/19 07:11 PMCR- 2026/03/03 CRDT- 2026/03/19 04:57 PHST- 2025/12/25 00:00 [received] PHST- 2026/02/13 00:00 [revised] PHST- 2026/02/19 00:00 [accepted] PHST- 2026/03/19 07:11 [medline] PHST- 2026/03/19 07:10 [pubmed] PHST- 2026/03/19 04:57 [entrez] PHST- 2026/03/03 00:00 [pmc-release] AID - 10.3389/fnut.2026.1775403 [doi] PST - epublish SO - Front Nutr. 2026 Mar 3;13:1775403. doi: 10.3389/fnut.2026.1775403. eCollection 2026. PMID- 41852354 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260319 LR - 20260813 IS - 2666-7762 (Electronic) IS - 2666-7762 (Linking) VI - 65 DP - 2026 Jun TI - Alignment of physical education curricula with physical literacy across Europe: an observational mapping study with country-level predictors. PG - 101641 LID - 10.1016/j.lanepe.2026.101641 [doi] LID - 101641 AB - BACKGROUND: Physical literacy (PL) is recognised by UNESCO and WHO for fostering lifelong physical activity. Although PL stands on the global agenda of health and education policies, analyses of the adoption by European education are scant. This study aimed to map the alignment of physical education with PL in Europe, explore potential predictors at country level, and identify country 'alignment laggards'. METHODS: Experts from 40 European countries assessed the alignment of national physical education curricula with PL using a pre-validated 15-indicator survey (alpha = 0.86). Country-level PL alignment scores were calculated and mapped. Regression models investigated whether these scores were predicted by educational attainment (PISA), human development (Human Development Index), relative economic strength (Gross Domestic Product/Capita), societal liberty (Human Freedom Index), and innovation spirit (Global Innovation Index). Residual errors were computed to identify association-adjusted 'laggards' in curricular PL alignment. FINDINGS: Significant heterogeneity in PL alignment existed across Europe. Estonia, Wales, Finland, and Norway showed the highest, and Romania, Croatia, Cyprus, and England the lowest PL alignment. Countries' educational attainment (beta = 0.43 [CI(95) 0.13, 0.65], p = 0.0062), human development (beta = 0.32 [CI(95) 0.011, 0.58], p = 0.043), and innovation spirit (beta = 0.32 [CI(95) 0.0071, 0.58], p = 0.046) were significantly associated with curricular PL alignment but not relative economic strength and liberty. A total of 17 European countries were consistent 'laggards' in curricular PL alignment across all significant predictors. INTERPRETATION: PL policies follow educational, developmental, and innovative gradients. Stakeholders should integrate PL as a strategic lever to transform physical education, guiding curricula and programmes to foster health through lifelong physical activity. FUNDING: None. CI - (c) 2026 The Author(s). FAU - Carl, Johannes AU - Carl J AD - Deakin University, Institute for Physical Activity and Nutrition, School of Health and Social Development, Geelong, VIC, Australia. FAU - Salin, Kasper AU - Salin K AD - University of Jyvaskyla, Faculty of Sport and Health Sciences, Jyvaskyla, Finland. FAU - Barnett, Lisa M AU - Barnett LM AD - Deakin University, Institute for Physical Activity and Nutrition, School of Health and Social Development, Geelong, VIC, Australia. FAU - Foweather, Lawrence AU - Foweather L AD - Liverpool John Moores University, Research Institute for Sport and Exercise Sciences, Liverpool (Merseyside), England, United Kingdom. FAU - Jurak, Gregor AU - Jurak G AD - University of Ljubljana, Faculty of Sport, Ljubljana, Slovenia. FAU - Martins, Joao AU - Martins J AD - Universidade de Lisboa, Instituto de Educacao, UIDEF e Faculdade de Motricidade Humana, Lisboa, Portugal. FAU - Muller, Ivan AU - Muller I AD - Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland. FAU - O'Brien, Wesley AU - O'Brien W AD - University College Cork, Physical Education, Sports Studies and Arts Programme, Cork, Ireland. FAU - Venetsanou, Fotini AU - Venetsanou F AD - National and Kapodistrian University of Athens, School of Physical Education and Sport Science, Dafni/Athens, Greece. FAU - Singh, Amika AU - Singh A AD - Mulier Institute, Utrecht, Netherlands. AD - Windesheim University of Applied Sciences, Zwolle, Netherlands. FAU - Elsborg, Peter AU - Elsborg P AD - Frederiksberg Hospital, Center for Clinical Research and Prevention, Frederiksberg, Denmark. FAU - Goss, Hannah AU - Goss H AD - Dublin City University, School of Health and Human Performance, Dublin, Ireland. FAU - Lundvall, Suzanne AU - Lundvall S AD - Department of Food and Nutrition and Sport Science, University of Gothenburg, Gothenburg, Sweden. AD - Department of Sport, Food and Natural Sciences, Western Norway University of Applied Sciences (HVL), Sogndal, Norway. FAU - Pavlova, Iuliia AU - Pavlova I AD - Department of Theory and Methods of Physical Culture, Ivan Boberskyj Lviv State University of Physical Culture, Lviv, Ukraine. FAU - D'Anna, Cristiana AU - D'Anna C AD - Department of Psychology and Education, Pegaso University, Naples, Italy. FAU - Vlcek, Petr AU - Vlcek P AD - Goethe University Frankfurt, Institute of Sports Sciences, Frankfurt am Main, Germany. CN - EUROPLIT group LA - eng PT - Journal Article DEP - 20260310 PL - England TA - Lancet Reg Health Eur JT - The Lancet regional health. Europe JID - 101777707 PMC - PMC12994078 OTO - NOTNLM OT - Children OT - Curriculum OT - Exercise OT - Physical activity OT - Schools OT - Teaching OT - Wellbeing COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. FIR - Alguren, Beatrix IR - Alguren B FIR - Antala, Branislav IR - Antala B FIR - Bartle, Gillian IR - Bartle G FIR - Birch, Jens IR - Birch J FIR - Bryant, Anna IR - Bryant A FIR - Carlos-Vivas, Jorge IR - Carlos-Vivas J FIR - Christodoulides, Efstathios IR - Christodoulides E FIR - Cowley, Joe G IR - Cowley JG FIR - Csanyi, Tamas IR - Csanyi T FIR - De Martelaer, Kristine IR - De Martelaer K FIR - Emeljanovas, Arunas IR - Emeljanovas A FIR - Eren, Gonca IR - Eren G FIR - Fernate, Andra IR - Fernate A FIR - Gilic, Barbara IR - Gilic B FIR - Gisladottir, Thordis IR - Gisladottir T FIR - Green, Nigel IR - Green N FIR - Groffik, Dorota IR - Groffik D FIR - Heck, Sandra IR - Heck S FIR - van Hilvoorde, Ivo IR - van Hilvoorde I FIR - Huhtiniemi, Mikko IR - Huhtiniemi M FIR - Iconomescu, Teodora-Mihaela IR - Iconomescu TM FIR - Jaunig, Johannes IR - Jaunig J FIR - Jones, Ellen IR - Jones E FIR - Kelso, Anne IR - Kelso A FIR - Koka, Andre IR - Koka A FIR - Kreinbucher-Bekerle, Christoph IR - Kreinbucher-Bekerle C FIR - Laudanska-Krzeminska, Ida IR - Laudanska-Krzeminska I FIR - Masanovic, Bojan IR - Masanovic B FIR - McFlynn, Paul IR - McFlynn P FIR - McKee, Melanie IR - McKee M FIR - Mendoza-Munoz, Maria IR - Mendoza-Munoz M FIR - Melby, Paulina S IR - Melby PS FIR - Mieziene, Brigita IR - Mieziene B FIR - Milanovic, Ivana IR - Milanovic I FIR - Mileva, Eleonora IR - Mileva E FIR - Mouton, Alexandre IR - Mouton A FIR - Nemeth, Zsolt IR - Nemeth Z FIR - Olaru, Bogdan Sorin IR - Olaru BS FIR - Onofre, Marcos IR - Onofre M FIR - Petrytsa, Petro IR - Petrytsa P FIR - Pihu, Maret IR - Pihu M FIR - Popeska, Biljana IR - Popeska B FIR - Popovic, Stevo IR - Popovic S FIR - Poweleit, Andre IR - Poweleit A FIR - Janic, Snezana Radisavljevic IR - Janic SR FIR - Riga, Vassiliki IR - Riga V FIR - Schnitzler, Christophe IR - Schnitzler C FIR - Sekulic, Damir IR - Sekulic D FIR - Semyonova, Marina IR - Semyonova M FIR - Smila, Baiba IR - Smila B FIR - Topfer, Clemens IR - Topfer C FIR - Tsivitanidou, Olia IR - Tsivitanidou O FIR - Vasickova, Jana IR - Vasickova J FIR - Winje, Oystein IR - Winje O FIR - Zito, Viviana IR - Zito V FIR - Yildizer, Gunay IR - Yildizer G EDAT- 2026/03/19 07:11 MHDA- 2026/03/19 07:12 PMCR- 2026/03/10 CRDT- 2026/03/19 04:53 PHST- 2025/10/06 00:00 [received] PHST- 2026/02/19 00:00 [revised] PHST- 2026/02/20 00:00 [accepted] PHST- 2026/03/19 07:12 [medline] PHST- 2026/03/19 07:11 [pubmed] PHST- 2026/03/19 04:53 [entrez] PHST- 2026/03/10 00:00 [pmc-release] AID - S2666-7762(26)00053-0 [pii] AID - 101641 [pii] AID - 10.1016/j.lanepe.2026.101641 [doi] PST - epublish SO - Lancet Reg Health Eur. 2026 Mar 10;65:101641. doi: 10.1016/j.lanepe.2026.101641. eCollection 2026 Jun. PMID- 41851929 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260711 IS - 1999-6217 (Electronic) IS - 1727-5482 (Linking) VI - 23 IP - 3 DP - 2026 Jan 26 TI - Prevalence and Risk Factors of Myopia among Undergraduate Students. PG - 457-466 LID - 10.33314/jnhrc.v23i03.4653 [doi] AB - BACKGROUND: This study aims to determine the prevalence of refractive error among undergraduate students in Far Western Nepal and association with ethnicity, parental history of myopia and environmental factors. METHODS: Non-interventional, cross-sectional study was done with random sampling involving 768 undergraduate students aged 18 to 26 years were included. Comprehensive ocular examinations were performed using non-cycloplegic refraction by single examiner. A structured, pre-validated questionnaire was used to gather personal demographics, outdoor activity levels, screen time, parental history of myopia, and ethnicity. RESULTS: The refractive error was found in 16.63% with myopia prevalent in 16.40% of the students. The findings revealed a significant association between myopia and several risk factors, including parental myopia (?=-0.86+/-0.05; p<0.001), extended near work (?=-0.60+/-0.08; p<0.001), and high screen time (?=-0.81+/-0.05; p<0.001). This significant association revealed higher incidences of myopia within academic departments that require intensive near visual tasks, especially in engineering department. Furthermore, ethnic variations indicated that Aryan students, particularly in the Brahmin and Chhetri communities has higher prevalence of myopia than other groups. CONCLUSIONS: The higher prevalence of myopia among the undergraduate students in Far West Nepal was seen at the age of 19. This study suggests the critical risk factors associated with myopia, including age, outdoor activities, screen time, parental history, and ethnic variations which need early health initiatives with preventive strategies for the growing incidence of myopia. FAU - Bhatta, Sabitri AU - Bhatta S AD - Geta Hospital, Kailali, Nepal. FAU - Kumar Yadav, Pramod AU - Kumar Yadav P AD - Geta Hospital, Kailali, Nepal. FAU - Awasthi, Suresh AU - Awasthi S AD - Geta Eye Hospital, Kailali, Nepal. FAU - Giri, Krishna AU - Giri K AD - Prithivi Narayan campus, Tribhuvan University, Kaski, Nepal. LA - eng PT - Journal Article DEP - 20260126 PL - Nepal TA - J Nepal Health Res Counc JT - Journal of Nepal Health Research Council JID - 101292936 SB - IM MH - Humans MH - *Myopia/epidemiology/ethnology MH - Nepal/epidemiology MH - Risk Factors MH - Cross-Sectional Studies MH - Young Adult MH - Prevalence MH - Female MH - Adolescent MH - Male MH - Adult MH - *Students/statistics & numerical data MH - Universities OTO - NOTNLM OT - Myopia: near work; outdoor activity; undergraduate students and ethnicity. EDAT- 2026/03/19 07:11 MHDA- 2026/03/19 07:12 CRDT- 2026/03/19 01:23 PHST- 2025/07/13 00:00 [received] PHST- 2026/01/25 00:00 [accepted] PHST- 2026/03/19 07:12 [medline] PHST- 2026/03/19 07:11 [pubmed] PHST- 2026/03/19 01:23 [entrez] AID - 10.33314/jnhrc.v23i03.4653 [doi] PST - epublish SO - J Nepal Health Res Counc. 2026 Jan 26;23(3):457-466. doi: 10.33314/jnhrc.v23i03.4653. PMID- 41851868 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Mar 19 TI - DAGIS Salo cohort profile: a longitudinal and cross-sectional study to identify environmental and individual factors linked to health behaviours, recovery from stress, weight and learning outcomes among Finnish schoolchildren. LID - 10.1186/s12889-026-27007-x [doi] LID - 1384 AB - BACKGROUND: The global prevalence of childhood obesity has increased significantly, with World Health Organisation emphasising the importance of early childhood for promoting healthy growth and development. In Finland, 29% of boys and 18% of girls aged 2-16 years are living with overweight or obesity. The DAGIS Intervention in 2017-2018 in Southwest Finland aimed to promote healthy energy-balance related behaviours (EBRBs) and self-regulation skills in early childhood education and family settings, hypothesising that improvements would reduce overweight prevalence, increase well-being, and enhance learning outcomes in pre-adolescence. DAGIS Salo is a follow-up study of the DAGIS Intervention, with parallel recruitment of a new cross-sectional sample. This paper describes the DAGIS Salo cohort profile, covering study design, recruitment, measurements, data processing and participant characteristics. METHODS: The DAGIS Salo study (2023-2024) consisted of a larger cross-sectional sample and, within it, a six-year follow-up sample from the DAGIS Intervention. All primary schoolchildren in grades 3-6 in Salo municipality in Southwest Finland and their caregivers were invited to participate, regardless of participation in the DAGIS Intervention. Schoolchildren provided information on movement behaviours (accelerometry), screen use, food consumption, psychosocial well-being, and recovery from stress (heart rate variability). Trained data collectors measured schoolchildren's anthropometrics and administered learning tests. Caregivers provided information on physical and social home environment and child temperament. School and food service personnel provided information on the school environment. RESULTS: The DAGIS Salo cohort consists of 540 schoolchildren (27% of eligible participants), including the DAGIS Intervention follow-up sample of 207 schoolchildren (31% of participants from the DAGIS Intervention). The average age of schoolchildren in the cohort was 11 (+/- 1.15) years and 54% of participants were girls. CONCLUSION: The DAGIS Salo study utilised a longitudinal and cross-sectional design, objective measures and validated instruments, and multiple perspectives to examine physical and social environments that influence schoolchildren's health and behaviour. Study findings can advance equity in schoolchildren's health, well-being and learning by identifying modifiable factors within early childhood education, home and school environments, to better support EBRBs, well-being and learning of those who need it most. TRIAL REGISTRATION: ISRCTN57165350 (8 January 2015). FAU - Kailaheimo-Bjorkqvist, Josefine AU - Kailaheimo-Bjorkqvist J AUID- ORCID: 0000-0002-5992-1758 AD - Folkhalsan Research Center, Topeliuksenkatu 20, Helsinki, 00250, Finland. AD - Institute of Applied Health Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK. FAU - Vepsalainen, Henna AU - Vepsalainen H AD - Department of Food and Nutrition, University of Helsinki, P.O. Box 66, Helsinki, 00014, Finland. FAU - Kesalainen, Jonna AU - Kesalainen J AD - School of Applied Educational Science and Teacher Education, University of Eastern Finland, P.O. Box 111, Joensuu, 80101, Finland. FAU - Lehto, Reetta AU - Lehto R AD - Folkhalsan Research Center, Topeliuksenkatu 20, Helsinki, 00250, Finland. AD - Department of Food and Nutrition, University of Helsinki, P.O. Box 66, Helsinki, 00014, Finland. FAU - Launistola, Henna AU - Launistola H AD - Folkhalsan Research Center, Topeliuksenkatu 20, Helsinki, 00250, Finland. FAU - Rahkola, Jenna AU - Rahkola J AD - Folkhalsan Research Center, Topeliuksenkatu 20, Helsinki, 00250, Finland. FAU - Kinnunen, Satu AU - Kinnunen S AD - Department of Food and Nutrition, University of Helsinki, P.O. Box 66, Helsinki, 00014, Finland. FAU - Tilli, Emmi AU - Tilli E AD - Folkhalsan Research Center, Topeliuksenkatu 20, Helsinki, 00250, Finland. AD - Department of Food and Nutrition, University of Helsinki, P.O. Box 66, Helsinki, 00014, Finland. FAU - Wackstrom, Nanna AU - Wackstrom N AD - Folkhalsan Research Center, Topeliuksenkatu 20, Helsinki, 00250, Finland. AD - Faculty of Medicine, University of Helsinki, PO BOX 63, Helsinki, 00014, Finland. FAU - Serasinghe, Nithya AU - Serasinghe N AD - Folkhalsan Research Center, Topeliuksenkatu 20, Helsinki, 00250, Finland. AD - Department of Food and Nutrition, University of Helsinki, P.O. Box 66, Helsinki, 00014, Finland. FAU - Muhumed, Idil AU - Muhumed I AD - Department of Food and Nutrition, University of Helsinki, P.O. Box 66, Helsinki, 00014, Finland. FAU - Klingstedt, Ossian AU - Klingstedt O AD - Folkhalsan Research Center, Topeliuksenkatu 20, Helsinki, 00250, Finland. AD - Faculty of Arts, Psychology and Theology, Akademi University, Tehtaankatu 2, Turku, 20500, Finland. FAU - Roos, Eva AU - Roos E AD - Folkhalsan Research Center, Topeliuksenkatu 20, Helsinki, 00250, Finland. AD - Department of Public Health, University of Helsinki, PO BOX 20, Helsinki, 00014, Finland. AD - Department of Food Studies, Nutrition and Dietetics, Uppsala University, PO Box 560, Uppsala, 751 22, Sweden. FAU - Sajaniemi, Nina AU - Sajaniemi N AD - School of Applied Educational Science and Teacher Education, University of Eastern Finland, P.O. Box 111, Joensuu, 80101, Finland. FAU - Erkkola, Maijaliisa AU - Erkkola M AD - Department of Food and Nutrition, University of Helsinki, P.O. Box 66, Helsinki, 00014, Finland. FAU - Ray, Carola AU - Ray C AD - Folkhalsan Research Center, Topeliuksenkatu 20, Helsinki, 00250, Finland. Carola.Ray@helsinki.fi. AD - Department of Food and Nutrition, University of Helsinki, P.O. Box 66, Helsinki, 00014, Finland. Carola.Ray@helsinki.fi. LA - eng PT - Journal Article DEP - 20260319 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Finland/epidemiology MH - Cross-Sectional Studies MH - Female MH - Child MH - Male MH - *Health Behavior MH - Longitudinal Studies MH - *Learning MH - *Stress, Psychological/epidemiology MH - *Pediatric Obesity/prevention & control/epidemiology MH - *Body Weight MH - Follow-Up Studies MH - Adolescent MH - *Health Promotion PMC - PMC13123094 OTO - NOTNLM OT - Adolescent OT - Children OT - Food intake OT - Intervention follow-up OT - Mental health OT - Physical activity OT - Preschool OT - Screen time OT - Sleep OT - Socioeconomic status COIS- Declarations. Ethics approval and consent to participate: Ethical approval was granted from the University of Helsinki Ethical Review Board in the Humanities and Social and Behavioural Sciences for both the DAGIS Intervention in 2017-2018 (statement 22/2017) and the DAGIS Salo study in 2023-2024 (statement 46/2023). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/19 07:10 MHDA- 2026/06/27 12:37 PMCR- 2026/03/19 CRDT- 2026/03/19 00:57 PHST- 2025/04/17 00:00 [received] PHST- 2026/03/10 00:00 [accepted] PHST- 2026/06/27 12:37 [medline] PHST- 2026/03/19 07:10 [pubmed] PHST- 2026/03/19 00:57 [entrez] PHST- 2026/03/19 00:00 [pmc-release] AID - 10.1186/s12889-026-27007-x [pii] AID - 27007 [pii] AID - 10.1186/s12889-026-27007-x [doi] PST - epublish SO - BMC Public Health. 2026 Mar 19;26(1):1384. doi: 10.1186/s12889-026-27007-x. PMID- 41850781 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260711 IS - 2047-6310 (Electronic) IS - 2047-6302 (Linking) VI - 21 IP - 3 DP - 2026 Mar TI - Machine Learning Prediction of Obesity Development in Children With Overweight Using Longitudinal Body Composition Data. PG - e70105 LID - 10.1111/ijpo.70105 [doi] AB - BACKGROUND: Children with overweight (body mass index [BMI] between the 85th and 95th percentiles) represent a critical target for obesity prevention, with obesity progression rates 10- to 20-fold higher than normal-weight peers. OBJECTIVES: This study developed machine learning models to predict obesity in this high-risk group using anthropometric and bioelectrical impedance analysis parameters. METHODS: We analysed longitudinal data from 2801 overweight Korean children aged 7-9 years. XGBoost models integrated anthropometric measurements, bioelectrical impedance-derived body composition, standardised deviation scores and growth velocity parameters to predict obesity (BMI >/= 95th percentile). Sex-stratified models were evaluated using area under the receiver operating characteristic curve (AUROC) with bootstrap validation. Shapley Additive exPlanations (SHAP) identified key predictive features. RESULTS: Obesity developed in 32.3% of males and 25.4% of females during follow-up. Models achieved AUROC scores of 0.671 (95% CI: 0.619-0.721) for males and 0.652 (95% CI: 0.589-0.700) for females. Key predictors included standardised weight and adiposity measures, height-adjusted skeletal muscle mass and growth velocity parameters. CONCLUSIONS: Machine learning models demonstrated effective predictive performance for obesity in children with overweight. Incorporating standardised adiposity measures and growth velocity beyond static anthropometric data provides a robust framework for risk stratification in this high-risk population. CI - (c) 2026 World Obesity Federation. FAU - Chun, Dohyun AU - Chun D AUID- ORCID: 0000-0003-3031-4011 AD - College of Business Administration, Kangwon National University, Chuncheon, Gangwon-do, Korea. AD - Research Team, GP Co. Ltd., Gwangmyeong-si, Gyeonggi-do, Korea. FAU - Rhie, Young-Jun AU - Rhie YJ AD - Department of Pediatrics, Korea University College of Medicine, Seoul, Korea. FAU - Sawyer, Jason AU - Sawyer J AD - Department of Biological and Biomedical Sciences, Bryant University, Smithfield, Rhode Island, USA. FAU - Kang, Jongho AU - Kang J AD - Research Team, GP Co. Ltd., Gwangmyeong-si, Gyeonggi-do, Korea. AD - College of Business Administration, Chonnam National University, Gwangju, Korea. FAU - Yoon, Nathan AU - Yoon N AD - Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, California, USA. FAU - Kim, Jihun AU - Kim J AUID- ORCID: 0000-0002-2957-8776 AD - Research Team, GP Co. Ltd., Gwangmyeong-si, Gyeonggi-do, Korea. AD - College of Humanities & Social Sciences Convergence, Yonsei University, Wonju, Gangwon-do, Korea. AD - Yonsei Institute of AI Data Convergence Science, Yonsei University, Wonju, Gangwon-do, Korea. LA - eng GR - 2025-RISE-10-006/the Ministry of Education (MOE) and the Gangwon State (G.S.), Republic of Korea/ GR - Regional Innovation System and Education (RISE) program/ PT - Journal Article PL - England TA - Pediatr Obes JT - Pediatric obesity JID - 101572033 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - *Body Composition MH - Longitudinal Studies MH - Body Mass Index MH - *Machine Learning MH - *Pediatric Obesity/epidemiology/diagnosis MH - Predictive Learning Models MH - Republic of Korea/epidemiology MH - Electric Impedance MH - Boosting Machine Learning Algorithms MH - *Overweight MH - Prediction Algorithms MH - Predictive Value of Tests OTO - NOTNLM OT - body composition OT - children with overweight OT - growth velocity OT - machine learning OT - paediatric obesity prediction EDAT- 2026/03/19 01:32 MHDA- 2026/03/19 01:33 CRDT- 2026/03/18 21:52 PHST- 2026/03/11 00:00 [revised] PHST- 2025/12/10 00:00 [received] PHST- 2026/03/12 00:00 [accepted] PHST- 2026/03/19 01:33 [medline] PHST- 2026/03/19 01:32 [pubmed] PHST- 2026/03/18 21:52 [entrez] AID - 10.1111/ijpo.70105 [doi] PST - ppublish SO - Pediatr Obes. 2026 Mar;21(3):e70105. doi: 10.1111/ijpo.70105. PMID- 41850572 OWN - NLM STAT- Publisher LR - 20260318 IS - 1098-4275 (Electronic) IS - 0031-4005 (Linking) DP - 2026 Mar 19 TI - Growth of Children With Cerebral Palsy and Health Outcomes. LID - e2025072504 [pii] LID - 10.1542/peds.2025-072504 [doi] AB - OBJECTIVE: The California-based cerebral palsy (CP) growth charts, published in Pediatrics in 2011, demonstrated a link between Gross Motor Function Classification System (GMFCS)-stratified weight percentile (GWt%-ile) and mortality, but use has been limited. This secondary analysis from the North American Growth in Cerebral Palsy Project (NAGCPP) aims to evaluate the charts and the link between GWt%-ile and additional health markers. PATIENTS AND METHODS: NAGCPP included weight and triceps skinfold thickness (TSF) in 197 boys and 146 girls, aged 2 to 18 years, GMFCS levels III through V, with CP. Health care utilization and social participation were assessed by questionnaire. GWt%-ile was determined from sex and GMFCS-specific weight charts. Using the 20th GWt%-ile cutoff previously associated with mortality risk over 3 years, we assessed the relationship with health care utilization and social participation with and without TSF and medical comorbidities. RESULTS: NAGCPP weight data fit the CP charts (goodness-of-fit P = .14 for boys; P > .25 for girls). Adjusting for sex and GMFCS, children below the 20th GWt%-ile reported 5.7 times (95% CI, 2.2-14.8) more hospital stays (P < .001), 3.1 times (95% CI, 1.3-7.4) more missed regular programs (P < .001), and 2.8 times (95% CI, 1.2-6.5) more total days (P = .02) the family or child missed regular activities. TSF (fat stores) and severe feeding problems were associated independently with health and participation. CONCLUSION: This study validates the CP growth charts and documents an association between GWt%-ile and markers of health and participation other than mortality. CP growth charts warrant consideration for clinical decision-making and research. CI - Copyright (c) 2026 by the American Academy of Pediatrics. FAU - Stevenson, Richard D AU - Stevenson RD AD - University of Virginia, Charlottesville, Virginia. FAU - Conaway, Mark R AU - Conaway MR AD - University of Virginia, Charlottesville, Virginia. FAU - Worley, Gordon AU - Worley G AD - Duke University, Durham, North Carolina. FAU - Stallings, Virginia A AU - Stallings VA AD - University of Pennsylvania and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. LA - eng PT - Journal Article DEP - 20260319 PL - United States TA - Pediatrics JT - Pediatrics JID - 0376422 SB - IM EDAT- 2026/03/19 01:32 MHDA- 2026/03/19 01:32 CRDT- 2026/03/18 20:16 PHST- 2025/05/18 00:00 [received] PHST- 2025/11/03 00:00 [accepted] PHST- 2026/03/19 01:32 [medline] PHST- 2026/03/19 01:32 [pubmed] PHST- 2026/03/18 20:16 [entrez] AID - 206907 [pii] AID - 10.1542/peds.2025-072504 [doi] PST - aheadofprint SO - Pediatrics. 2026 Mar 19:e2025072504. doi: 10.1542/peds.2025-072504. PMID- 41850077 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260713 IS - 1873-6297 (Electronic) IS - 0001-6918 (Linking) VI - 265 DP - 2026 May TI - Longitudinal associations between physical activity, academic self-efficacy, self-esteem, and depression in Chinese junior high school students. PG - 106688 LID - S0001-6918(26)00489-0 [pii] LID - 10.1016/j.actpsy.2026.106688 [doi] AB - Grounded in Self-Determination Theory and Social Cognitive Theory, this longitudinal study examined reciprocal relationships among MVPA, academic self-efficacy (ASE), self-esteem, and depression in 640 Chinese junior high school students (Mage = 13.26, SD = 0.76). Validated measures were administered at two time points over six months. Results showed significant autoregressive effects and key cross-lagged paths: higher self-esteem at Time 1 predicted lower depression at Time 2, while higher depression at Time 1 negatively predicted MVPA at Time 2. However, MVPA at Time 1 did not significantly predict later depression. These findings suggest that internal beliefs and psychological needs do not function in isolation. Enhancing adolescents' competence (ASE) and confidence (self-esteem) may be essential for improving mental health. This study offers theoretical and practical implications for school-based interventions integrating physical activity and psychological development. EDUCATIONAL RELEVANCE STATEMENT: This study provided longitudinal insights into the psychological and behavioral factors influencing junior high school students' well-being. The findings showed that earlier depressive symptoms significantly predicted lower levels of physical activity six months later. Academic self-efficacy and self-esteem demonstrated strong temporal stability, while self-esteem-but not academic self-efficacy-significantly predicted reduced depressive symptoms over time. These results emphasized the need for early mental health interventions in school settings and suggested that promoting self-esteem may serve as a more effective approach to prevent adolescent depression than focusing solely on academic self-beliefs. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Bai, Dan AU - Bai D AD - Department of Sports, Quzhou University, Quzhou, China. Electronic address: dan20@graduate.utm.my. FAU - Liu, Xiaoming AU - Liu X AD - School of Physical Education, Hunan Normal University, Changsha, China. LA - eng PT - Journal Article DEP - 20260317 PL - Netherlands TA - Acta Psychol (Amst) JT - Acta psychologica JID - 0370366 RN - Chinese people SB - IM MH - Humans MH - *Self Efficacy MH - *Self Concept MH - Adolescent MH - *Depression/psychology MH - Female MH - Longitudinal Studies MH - Male MH - *Students/psychology MH - *Exercise/psychology MH - China/epidemiology MH - East Asian People OTO - NOTNLM OT - Academic self-efficacy OT - Depression OT - Junior high school students OT - Longitudinal analysis OT - Physical activity OT - Self-esteem COIS- Declaration of competing interest The authors declare no conflicts of interest. EDAT- 2026/03/19 01:31 MHDA- 2026/04/19 17:46 CRDT- 2026/03/18 19:16 PHST- 2025/08/09 00:00 [received] PHST- 2026/03/12 00:00 [revised] PHST- 2026/03/13 00:00 [accepted] PHST- 2026/04/19 17:46 [medline] PHST- 2026/03/19 01:31 [pubmed] PHST- 2026/03/18 19:16 [entrez] AID - S0001-6918(26)00489-0 [pii] AID - 10.1016/j.actpsy.2026.106688 [doi] PST - ppublish SO - Acta Psychol (Amst). 2026 May;265:106688. doi: 10.1016/j.actpsy.2026.106688. Epub 2026 Mar 17. PMID- 41849442 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 3 DP - 2026 TI - Sociodemographic influences on Student Mental Health and their association with activation-regulating functional impairments. PG - e0342731 LID - 10.1371/journal.pone.0342731 [doi] LID - e0342731 AB - Activation-regulating functions, grounded in Executive Function Theory, Self-Regulation Theory, and the Dysexecutive (DEX) Framework, refer to higher-order cognitive processes such as task initiation, sustained attention, planning, and prioritization that enable individuals to translate intentions into goal-directed action. In the university context, these functions are central to managing complex academic demands, organizing study activities, meeting deadlines, and maintaining engagement. Impairments in activation-regulating functions may increase stress, undermine motivation, and negatively affect mental health and overall well-being, particularly in the presence of persistent digital distractions such as smartphone use. This self-reported cross-sectional study involved 1204 participants and utilized the validated Arabic version of the activation dysexecutive questionnaire. Alongside this, demographic information and data on potential influencing factors were also collected. Significant differences were found, with various factors positively correlated with higher scores, indicating worse symptoms of activation dysfunction. Several of these factors are related to common Generation Z habits, such as the number of hours spent using smartphones or electronic devices ([Formula: see text]), number of weekly fast food consumption times ([Formula: see text]), number of social media platforms used ([Formula: see text]) and daily hours spent on social media ([Formula: see text]). Whereas, increasing number of weekly hours exercising/playing sports was correlated with lower dysfunction scores ([Formula: see text]). Other contributing factors include weak relationships with extended family ([Formula: see text]), specific family income groups ([Formula: see text]), specific GPA groups ([Formula: see text]), area of living ([Formula: see text]), previous consultations with a psychologist/psychiatrist ([Formula: see text]), and parental divorce ([Formula: see text]). On the other hand, participating in sports and exercising had a good impact on the activation subscale score ([Formula: see text]). So did having strong relationships with extended family ([Formula: see text]) and living with parents ([Formula: see text]). The study reveals significant factors affecting activation functions among university students, particularly Generation Z, with increased smartphone and social media use, frequent fast food consumption, weak familial relationships, and past mental health consultations linked to worse activation dysfunction. Conversely, participation in sports, strong family ties, and living with parents positively influence activation levels. To address these challenges, universities should promote healthier lifestyles through workshops on digital well-being and nutrition, encourage physical activity through organized sports, and provide resources for family counseling. Additionally, ensuring accessible mental health services can support students in navigating activation-related issues, fostering an environment conducive to both academic success and personal growth. CI - Copyright: (c) 2026 Fraiwan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Fraiwan, Mohammad AU - Fraiwan M AUID- ORCID: 0000-0001-6352-5275 AD - Faculty of Computer and Information Technology, Jordan University of Science and Technology, Irbid, Jordan. FAU - Almomani, Fidaa AU - Almomani F AD - Department of Rehabilitation Sciences, Jordan University of Science and Technology, Irbid, Jordan. FAU - Hammouri, Hanan AU - Hammouri H AD - Department of Mathematics and Statistics, Jordan University of Science and Technology, Irbid, Jordan. LA - eng PT - Journal Article DEP - 20260318 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Mental Health MH - *Students/psychology MH - Female MH - Cross-Sectional Studies MH - Male MH - Young Adult MH - Adult MH - Surveys and Questionnaires MH - *Executive Function MH - Universities MH - Adolescent MH - Socioeconomic Factors MH - Media Exposure MH - Self Report MH - Self-Control/psychology MH - Social Media PMC - PMC12998822 COIS- The authors have declared that no competing interests exist. EDAT- 2026/03/18 18:36 MHDA- 2026/03/18 18:37 PMCR- 2026/03/18 CRDT- 2026/03/18 13:52 PHST- 2025/07/15 00:00 [received] PHST- 2026/01/27 00:00 [accepted] PHST- 2026/03/18 18:37 [medline] PHST- 2026/03/18 18:36 [pubmed] PHST- 2026/03/18 13:52 [entrez] PHST- 2026/03/18 00:00 [pmc-release] AID - PONE-D-25-38369 [pii] AID - 10.1371/journal.pone.0342731 [doi] PST - epublish SO - PLoS One. 2026 Mar 18;21(3):e0342731. doi: 10.1371/journal.pone.0342731. eCollection 2026. PMID- 41846838 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Identification of preschool children's physical fitness phenotypes and their association with multidimensional body shape indicators: a data-driven approach with risk prediction modeling. PG - 1773424 LID - 10.3389/fpubh.2026.1773424 [doi] LID - 1773424 AB - OBJECTIVE: Traditional physical fitness assessments in young children often rely on single indicators, which fail to capture integrated ability patterns. The common use of body mass index (BMI) to link morphology and fitness has limited discriminant validity. This study aimed to identify naturally emerging physical fitness profiles among preschool children in Macao using a data-driven approach and to develop a screening tool based on multi-dimensional body shape indicators-beyond BMI-for identifying children at risk of low physical fitness. METHODS: The sample comprised 3,180 children aged 3-6 years from the Macao China Physical Fitness Surveillance and Physical Activity Survey (2010, 2015, 2020). K-means clustering was performed on six standardized physical fitness test scores to identify intrinsic fitness profiles. One-way ANOVA was used to compare body shape indicators across clusters. Using the low-fitness cluster as the dependent variable, logistic regression identified key morphological predictors, from which a composite discriminant index was constructed. Predictive performance was evaluated using receiver operating characteristic (ROC) curve analysis. RESULTS: Cluster analysis revealed three distinct physical fitness profiles: low, moderate, and high fitness. ANOVA showed significant gradient differences across clusters for all body shape indicators (height, weight, circumferences, etc.). Effect sizes (Cohen's f) ranged from 0.025 to 0.190. Logistic regression identified four core predictors: height, weight, waist circumference, and pelvic width. The composite body shape index demonstrated good discriminative ability for low fitness risk, with an area under the curve (AUC) of 0.779 (95% CI: 0.742-0.800). At the optimal cut-off, sensitivity was 77.7%, and specificity was 66.8%. The index showed consistent performance in sex-stratified analyses (Boys: AUC = 0.87; Girls: AUC = 0.88). CONCLUSION: This study confirms that preschool children's physical fitness develops in distinct, internally coherent profiles, closely associated with body morphology. The composite index based on waist circumference and pelvic width-among other measures-proves more effective than BMI alone in identifying children at risk of low fitness. It offers a practical tool for rapid, early screening during routine health checks and supports targeted physical activity interventions. CI - Copyright (c) 2026 Chen, Zhao, Zhang, Pan, Wang, Chen and Zhang. FAU - Chen, Xiaoxiao AU - Chen X AD - School of Physical Education and Sports Rehabilitation, Jinzhou Medical University, Jinzhou, Liaoning, China. FAU - Zhao, Deqiang AU - Zhao D AD - China Institute of Sport Science, Beijing, China. FAU - Zhang, Aoyu AU - Zhang A AD - School of Medicine, Tianshi College of Tianjin, Tianjin, China. FAU - Pan, Xiang AU - Pan X AD - Graduate School of Health and Sports Science, Juntendo University, Inzai, Japan. FAU - Wang, Chuanmiao AU - Wang C AD - School of Physical Education and Sports Rehabilitation, Jinzhou Medical University, Jinzhou, Liaoning, China. FAU - Chen, Jiaxin AU - Chen J AD - School of Physical Education and Sports Rehabilitation, Jinzhou Medical University, Jinzhou, Liaoning, China. FAU - Zhang, Yanfeng AU - Zhang Y AD - China Institute of Sport Science, Beijing, China. LA - eng PT - Journal Article DEP - 20260302 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Physical Fitness/physiology MH - Phenotype MH - Child, Preschool MH - Female MH - China MH - Male MH - Child MH - Body Mass Index MH - Cluster Analysis MH - Clustering Algorithms MH - Risk Assessment PMC - PMC12989526 OTO - NOTNLM OT - body shape indicators OT - cluster analysis OT - physical fitness phenotypes OT - preschool children OT - risk prediction COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/18 07:25 MHDA- 2026/03/18 07:26 PMCR- 2026/03/02 CRDT- 2026/03/18 04:34 PHST- 2025/12/22 00:00 [received] PHST- 2026/02/07 00:00 [revised] PHST- 2026/02/12 00:00 [accepted] PHST- 2026/03/18 07:26 [medline] PHST- 2026/03/18 07:25 [pubmed] PHST- 2026/03/18 04:34 [entrez] PHST- 2026/03/02 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1773424 [doi] PST - epublish SO - Front Public Health. 2026 Mar 2;14:1773424. doi: 10.3389/fpubh.2026.1773424. eCollection 2026. PMID- 41843557 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 3 DP - 2026 TI - Development and validation of a health education module for parents of schoolchildren with overweight and obesity in the UAE. PG - e0344967 LID - 10.1371/journal.pone.0344967 [doi] LID - e0344967 AB - BACKGROUND: Childhood overweight and obesity continue to rise globally and in the United Arab Emirates (UAE), underscoring the need for accessible, evidence-based parental education tools. OBJECTIVE: This study aims to develop and validate a health educational module (HEM) tailored for parents of schoolchildren with overweight and obesity in the UAE. METHODS: The study was conducted in two phases: module development, and content and face validation. The module development involved an extensive review of national and international guidelines and previous research, followed by the design of infographic-based educational messages. Content and Face Validity were performed by six nutrition experts and 16 parents, respectively, using the Content Validity Index (CVI) and Face Validity Index (FVI). RESULTS: The final HEM consisted of 25 infographic messages covering dietary intake, physical activity, behavior change, and family engagement. The module achieved excellent content validity (S-CVI/Ave = 0.97) and face validity (S-FVI/Ave = 0.99). Participant feedback resulted in language refinement, improved illustrations, and removal of outdated elements such as the Food Pyramid. CONCLUSION: The validated HEM is culturally relevant, parent-friendly, and scientifically grounded. It offers a structured, high-quality educational tool suitable for use in research, school-based initiatives, and public-health programs aimed at reducing childhood obesity in the UAE. CI - Copyright: (c) 2026 Mustafaalsaafin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Mustafaalsaafin, Heba S M AU - Mustafaalsaafin HSM AD - Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. AD - Nutrition Program, School of Health Sciences, Universiti Sains Malaysia, Kelantan, Malaysia. FAU - Mohamed, Hamid Jan B Jan AU - Mohamed HJBJ AD - Nutrition Program, School of Health Sciences, Universiti Sains Malaysia, Kelantan, Malaysia. FAU - Yusoff, Hafzan AU - Yusoff H AD - Nutrition Program, School of Health Sciences, Universiti Sains Malaysia, Kelantan, Malaysia. FAU - Hashim, Mona AU - Hashim M AD - Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. AD - Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. FAU - Radwan, Hadia AU - Radwan H AD - Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. AD - Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. FAU - Cheikh Ismail, Leila AU - Cheikh Ismail L AD - Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. AD - Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. AD - Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, United Kingdom. FAU - Mohamad, Maysm N AU - Mohamad MN AUID- ORCID: 0000-0002-6396-6625 AD - Department of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. FAU - Almassri, Heba F AU - Almassri HF AD - Nutrition Program, School of Health Sciences, Universiti Sains Malaysia, Kelantan, Malaysia. FAU - Hasan, Hayder AU - Hasan H AUID- ORCID: 0000-0001-5580-1911 AD - Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. AD - Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. LA - eng PT - Journal Article PT - Validation Study DEP - 20260317 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - United Arab Emirates/epidemiology MH - *Parents/education MH - *Health Education/methods MH - Child MH - Female MH - Male MH - *Overweight MH - *Pediatric Obesity/prevention & control MH - Adult MH - Obesity MH - Exercise PMC - PMC12994848 COIS- The authors have declared that no competing interests exist. EDAT- 2026/03/18 12:52 MHDA- 2026/03/18 12:53 PMCR- 2026/03/17 CRDT- 2026/03/17 13:33 PHST- 2025/07/23 00:00 [received] PHST- 2026/02/27 00:00 [accepted] PHST- 2026/03/18 12:53 [medline] PHST- 2026/03/18 12:52 [pubmed] PHST- 2026/03/17 13:33 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - PONE-D-25-37277 [pii] AID - 10.1371/journal.pone.0344967 [doi] PST - epublish SO - PLoS One. 2026 Mar 17;21(3):e0344967. doi: 10.1371/journal.pone.0344967. eCollection 2026. PMID- 41840702 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260901 IS - 2046-4053 (Electronic) IS - 2046-4053 (Linking) VI - 15 IP - 1 DP - 2026 Mar 17 TI - Chatbot-based interventions for improvement of diet, physical activity, and tobacco use behaviors: protocol for a systematic review. LID - 10.1186/s13643-026-03154-5 [doi] LID - 142 AB - BACKGROUND: This systematic review aims to summarize the effectiveness, acceptability, and potential mechanisms of chatbot-based interventions in improving diet, physical activity, and tobacco use behaviors. METHODS: This protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). We will include individual- or cluster-randomized, parallel-group controlled trials that compare chatbot-based interventions with active-control, waiting-list, or usual-control comparators among children, adults, and the elderly irrespective of their behavioral patterns at baseline. We will also include the non-randomized or single-group trials to expand the evidence base. The primary outcomes will be the change in diet, physical activity, and tobacco use behaviors assessed by validated questionnaires or objective measures. The secondary outcomes will include the change in obesity-related outcomes, stage of behavioral change, change of motivation, emotion, knowledge, or other constructs that might mediate the intervention effect, chatbot use behaviors during the process of intervention implementation, the facilitators and barriers to chatbot use, and safety issues. We will search both the studies published in PubMed, EMBASE, ACM Digital Library, Web of Science, PsycINFO, CINAHL, and IEEE and the unpublished studies in the WHO's International Clinical Trials Registry Platform, ClinicalTrials.gov, conference proceedings, GitHub, and arXiv. We will group the included studies based on their consistency in the Population, Intervention, Comparator, Outcome and Study design (PICOS) elements for data synthesis. The random-effects meta-analysis will be used to quantitatively synthesize the results across studies if data permits; otherwise, we will synthesize the study results based on the guideline of Synthesis Without Meta-analysis (SWiM). We will use the correlation-based meta-analytical structural equation modeling approach to examine the presence of mediators of chatbot-based interventions. We will assess the risk of bias for each included study using the revised version of the Cochrane risk-of-bias tool for randomized trials (RoB 2) or the Risk of Bias In Non-randomized Studies of Interventions (ROBINS-I), and appraise the certainty of the evidence for each synthesized result using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. DISCUSSION: This systematic review will not only answer whether the state-of-the-art chatbot-based interventions are acceptable and effective in changing a person's diet, physical activity, and tobacco use behaviors but also explore the potential mechanisms underlying the effects of the chatbot-based interventions. The findings of this study will pave the way for optimizing future chatbot-based interventions in the field of health-related behaviors. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42023492013. CI - (c) 2026. The Author(s). FAU - Liu, Zheng AU - Liu Z AUID- ORCID: 0000-0002-0405-2348 AD - Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, 100191, China. liuzheng@bjmu.edu.cn. FAU - Yang, Yang AU - Yang Y AD - Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, 100191, China. FAU - Chen, Jing AU - Chen J AD - Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, 100191, China. FAU - Zhang, Shang-Hang AU - Zhang SH AD - National Key Laboratory for Multimedia Information Processing, School of Computer Science, Peking University, Beijing, China. FAU - Zhang, Xiao-Rui AU - Zhang XR AD - Department of Pediatric, Peking University People's Hospital, Beijing, China. FAU - Zhuang, Yu-Xuan AU - Zhuang YX AD - Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, 100191, China. FAU - Hu, Run-Ze AU - Hu RZ AD - Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, 100191, China. LA - eng GR - BECA23111/Beijing Education Sciences Planning Program during the 14th Five-Year Plan/ GR - 2023QNRC001/Young Elite Scientists Sponsorship Program by CAST/ GR - 82373694/National Natural Science Foundation of China/ PT - Journal Article DEP - 20260317 PL - England TA - Syst Rev JT - Systematic reviews JID - 101580575 SB - IM MH - Humans MH - Systematic Reviews as Topic MH - *Exercise MH - *Diet MH - *Tobacco Use/prevention & control MH - *Health Behavior MH - *Health Promotion/methods MH - Research Design PMC - PMC13107892 OTO - NOTNLM OT - Chatbot OT - Diet OT - Intervention OT - Physical activity OT - Systematic review OT - Tobacco use COIS- Declarations. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/03/17 06:47 MHDA- 2026/04/24 06:33 PMCR- 2026/03/17 CRDT- 2026/03/17 01:04 PHST- 2024/04/27 00:00 [received] PHST- 2026/03/07 00:00 [accepted] PHST- 2026/04/24 06:33 [medline] PHST- 2026/03/17 06:47 [pubmed] PHST- 2026/03/17 01:04 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - 10.1186/s13643-026-03154-5 [pii] AID - 3154 [pii] AID - 10.1186/s13643-026-03154-5 [doi] PST - epublish SO - Syst Rev. 2026 Mar 17;15(1):142. doi: 10.1186/s13643-026-03154-5. PMID- 41840697 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Mar 16 TI - Exercise motivation patterns in emerging adults: dual roles of weight and shape concern in activation and inhibition pathways. LID - 10.1186/s40359-026-04366-z [doi] LID - 597 AB - BACKGROUND: Exercise motivation constitutes a key determinant of physical activity(PA). However, prior research has predominantly adopted a variable-centered approach, thereby overlooking the coexistence of multiple motivational goals within individuals. Moreover, in the context of increasing body image concerns, the relationship between body-related concerns and individuals' patterns of exercise motivation warrants further investigation. The work aimed to assess latent profiles of exercise motivation among Chinese emerging adult males and females, the association of weight and shape concern (WSC) with motivation profiles, and differences in PA across these profiles. METHODS: A total of 2,112 Chinese emerging adults were surveyed using validated instruments measuring exercise motivation, WSC, and PA. Latent profile analysis (LPA) was conducted to identify motivation profiles. Multinomial logistic regression was used to examine associations of WSC with profile membership, with body mass index (BMI) included as a covariate. Differences in PA across profiles were analyzed using one-way ANOVA. RESULTS: LPA identified four profiles in the male sample: low-motivation profile, fitness-oriented profile, moderate low-motivation profile, and high-motivation profile. Five profiles were identified in the female samples: low-motivation profile, moderate low-motivation profile, low social-oriented profile, high-motivation profile, and enjoyment and social-oriented profile. WSC was significantly associated with motivation profile membership. For males, higher WSC was associated with a higher likelihood of classification into the high-motivation profile. For females, however, WSC showed a dual association, associated with a higher likelihood of both the high-motivation and low-motivation or low social-oriented profiles. PA varied significantly across profiles. For males, the high-motivation profile exhibited significantly greater PA than all other profiles. For females, the high-motivation profile demonstrated higher PA levels than the low-, moderate low-, and enjoyment and social-oriented profiles, but did not differ significantly from the low social-oriented profile. CONCLUSIONS: Exercise motivation exhibited significant heterogeneity among emerging adults in China. WSC was significantly associated with profile membership in both males and females. Overall, these findings highlight the importance of considering diverse motivational configurations and body image concerns in efforts to promote physical activity. FAU - Wu, Jiahao AU - Wu J AD - College of Exercise and Health, Shenyang Sport University, Liaoning, China. FAU - Guo, Zeyou AU - Guo Z AD - College of Physical Education and Sports, Beijing Normal University, Beijing, China. FAU - Tang, Wenxuan AU - Tang W AD - College of Exercise and Health, Shenyang Sport University, Liaoning, China. FAU - Sun, Siyao AU - Sun S AD - College of Exercise and Health, Shenyang Sport University, Liaoning, China. FAU - Sun, Mingwei AU - Sun M AD - College of Exercise and Health, Shenyang Sport University, Liaoning, China. FAU - Wang, Yiming AU - Wang Y AD - College of Exercise and Health, Shenyang Sport University, Liaoning, China. FAU - Dou, Guangbo AU - Dou G AD - College of Exercise and Health, Shenyang Sport University, Liaoning, China. douguangbo@lnu.edu.cn. AD - School of Psychology , Bournemouth University, Bournemouth, UK. douguangbo@lnu.edu.cn. LA - eng GR - LJ132410176014/Scientific Research Funding Project of Liaoning Provincial Department of Education-Basic Research Project/ PT - Journal Article DEP - 20260316 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - *Motivation MH - Male MH - Female MH - *Exercise/psychology MH - Young Adult MH - *Body Weight MH - *Body Image/psychology MH - China MH - Adult MH - Adolescent PMC - PMC13107578 OTO - NOTNLM OT - Exercise motivation OT - Latent profile analysis OT - Physical activity OT - Weight and shape concern COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of Shenyang Sport University (approval number: 202510). Informed consent was obtained from all participants involved in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/17 06:47 MHDA- 2026/06/27 12:38 PMCR- 2026/03/16 CRDT- 2026/03/17 01:04 PHST- 2025/11/27 00:00 [received] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/06/27 12:38 [medline] PHST- 2026/03/17 06:47 [pubmed] PHST- 2026/03/17 01:04 [entrez] PHST- 2026/03/16 00:00 [pmc-release] AID - 10.1186/s40359-026-04366-z [pii] AID - 4366 [pii] AID - 10.1186/s40359-026-04366-z [doi] PST - epublish SO - BMC Psychol. 2026 Mar 16;14(1):597. doi: 10.1186/s40359-026-04366-z. PMID- 41840600 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 25 IP - 1 DP - 2026 Mar 17 TI - Validation of the web-based dietary assessment tool (RiksmatenFlex) against doubly labelled water and 24-h dietary recalls in Swedish pre-school children. LID - 10.1186/s12937-026-01315-9 [doi] LID - 40 AB - BACKGROUND: RiksmatenFlex, a Swedish' web-based dietary assessment method, has previously been validated in adolescents and pregnant women. The aim of this study was to evaluate RiksmatenFlex in preschool children by comparing energy intake with total energy expenditure (TEE) measured by the doubly labelled water (DLW) method, by comparing reported intakes of energy, foods, macro- and micronutrients with 24-h dietary recall interviews, and by assessing the parents' perceptions of reporting their child's dietary intake. METHODS: Participants were 94 healthy children, 37 +/- 15 months old, 51% girls, recruited through advertisements (preschools/social media). Energy, selected nutrient and food group intakes were assessed using RiksmatenFlex as a food diary and 24-h dietary recall interviews. TEE (DLW) was measured in a subsample of 37 children. RESULTS: Average energy intake was overestimated by RiksmatenFlex compared to TEE (796 kJ; 21%; P < 0.001) in the subsample. The Bland-Altman plot showed wide limits of agreement (+/- 1797 kJ), and bias towards overreporting at higher intake levels (r = 0.34; P = 0.038). Energy intake and absolute intakes of protein, fat, carbohydrates, calcium (also energy standardised) and fruit-vegetables (combined) were significantly higher with RiksmatenFlex than with the 24-h dietary recalls. Other nutrient and food group intakes were fairly similar with the two methods. Spearman rank correlations ranged from 0.73 (wholegrains) to 0.98 (baby foods). Agreement between the two methods was substantial (K(W)>0.61) for most dietary variables, but not wholegrains, and proportion of energy from macronutrients (K(W) 0.50-0.60). Parents found reporting food intake in RiksmatenFlex easy, with most preferring on-line reporting over interviews. CONCLUSION: The current study showed reasonable validity in young children and the method was well accepted by parents. These finding support its application in large-scale studies of young children, though potential overreporting of energy intake warrants attention. CI - (c) 2026. The Author(s). FAU - Lindroos, Anna Karin AU - Lindroos AK AD - Department of Food Studies, Nutrition and Dietetics, Uppsala university, Box 560, Uppsala, SE-751 22, Sweden. annakarin.lindroos@ikv.uu.se. AD - Department of Risk Benefit Assessment, Swedish Food Agency, Uppsala, Sweden. annakarin.lindroos@ikv.uu.se. FAU - Sipinen, Jessica Petrelius AU - Sipinen JP AD - Department of Risk Benefit Assessment, Swedish Food Agency, Uppsala, Sweden. FAU - Rood, Jennifer AU - Rood J AD - Pennington Biomedical Research Center, Baton Rouge, LA, USA. FAU - Lof, Marie AU - Lof M AD - Department of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden. FAU - Augustin, Hanna AU - Augustin H AD - Department of Internal Medicine and Clinical Nutrition, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Hoppe, Michael AU - Hoppe M AD - Department of Internal Medicine and Clinical Nutrition, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Moraeus, Lotta AU - Moraeus L AD - Department of Risk Benefit Assessment, Swedish Food Agency, Uppsala, Sweden. LA - eng PT - Journal Article PT - Validation Study DEP - 20260317 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 RN - 0 (Micronutrients) SB - IM MH - Humans MH - Female MH - Child, Preschool MH - Energy Intake MH - Sweden MH - *Nutrition Assessment MH - Diet Records MH - Mental Recall MH - Male MH - Energy Metabolism MH - *Internet MH - *Diet MH - Reproducibility of Results MH - Micronutrients/administration & dosage MH - *Diet Surveys/methods PMC - PMC13063513 OTO - NOTNLM OT - Diet assessment OT - Energy expenditure OT - Energy intake OT - Food intake OT - Young children COIS- Declarations. Ethics approval and consent to participate: Ethical approval was granted from the Swedish Ethical Review Authority (2020-05293). Written informed consent was collected from both parents before starting the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/17 06:48 MHDA- 2026/04/10 06:32 PMCR- 2026/03/17 CRDT- 2026/03/17 00:59 PHST- 2026/01/06 00:00 [received] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/04/10 06:32 [medline] PHST- 2026/03/17 06:48 [pubmed] PHST- 2026/03/17 00:59 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - 10.1186/s12937-026-01315-9 [pii] AID - 1315 [pii] AID - 10.1186/s12937-026-01315-9 [doi] PST - epublish SO - Nutr J. 2026 Mar 17;25(1):40. doi: 10.1186/s12937-026-01315-9. PMID- 41838628 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 3 DP - 2026 TI - Assessing the impact of a tennis-themed sports video game on physical literacy and participation on physical activities among university students: A cluster randomized controlled trial study protocol. PG - e0343594 LID - 10.1371/journal.pone.0343594 [doi] LID - e0343594 AB - INTRODUCTION: Physical literacy (PL) is a multidimensional construct encompassing motivation, confidence, physical competence, knowledge, and understanding, which is essential for fostering lifelong physical activity. University students represent a critical stage for PL development, yet many experience a decline in physical activity and an increase in sedentary behavior after high school. Sports video games (SVGs), though traditionally sedentary, have shown potential to enhance motivation and cognitive engagement with sports. These games are especially popular among university students, making them an accessible and engaging tool for promoting PL. Despite their popularity, the role of SVGs in supporting PL development remains underexplored, particularly in Asian contexts. Integrating technology into physical education, such as through SVGs and virtual simulations, may offer innovative ways to enhance engagement and support PL development. Although the intervention is sedentary, SVG gameplay often requires reflexes and eye-hand coordination which may influence aspects of physical competence such as reaction time and coordination. This study aims to evaluate whether a tennis-themed SVG intervention integrated into PE lessons can enhance students' motivation, sport-specific knowledge, physical competence, social engagement, and physical activity engagement, thereby promoting holistic PL development. METHODS: A cluster randomized controlled trial will be conducted with 176 first-year students enrolled in compulsory tennis physical education courses at The Chinese University of Hong Kong. Eight entire classes (four male and four female) will be randomly assigned to either an intervention or control group. The intervention group will play a tennis SVG, TopSpin 2K25, twice weekly for six weeks alongside regular PE lessons. Assessments at baseline, post-intervention, and three-week follow-up will include self-reported gaming behavior, physical activity level, PL domains, and objective tests of reaction time, eye-hand coordination, and tennis knowledge. DISCUSSION: This protocol examines the integration of SVG into physical education to promote PL across physical, cognitive, affective, and social domains. Limitations include potential contamination bias, variability in prior gaming experience, short intervention duration, and reliance on self-reported measures, which may introduce bias. Theoretically, the study advances PL frameworks by embedding technology-enhanced learning within structured PE contexts. Practically, SVG-based activities offer an inclusive, engaging approach to support diverse learners. Future research should explore long-term effects and develop validated tools for comprehensive assessment. Trial registration: The protocol has been registered on the Open Science Framework on 25 July 2025: https://doi.org/10.17605/OSF.IO/JDYGV. CI - Copyright: (c) 2026 Ho et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Ho, Wai Keung AU - Ho WK AUID- ORCID: 0000-0003-0387-9869 AD - Department of Sports Science and Physical Education, Faculty of Education, The Chinese University of Hong Kong, Hong Kong, China. AD - Physical Education Unit, Faculty of Education, The Chinese University of Hong Kong, Hong Kong, China. FAU - Sum, Raymond Kim Wai AU - Sum RKW AUID- ORCID: 0000-0002-4051-9945 AD - Department of Sports Science and Physical Education, Faculty of Education, The Chinese University of Hong Kong, Hong Kong, China. FAU - Choi, Siu Ming AU - Choi SM AD - Faculty of Education, The University of Macau, Macau, China. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20260316 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Video Games MH - *Students/psychology MH - *Tennis MH - Universities MH - *Exercise/psychology MH - Female MH - Randomized Controlled Trials as Topic MH - Motivation MH - Male MH - *Physical Education and Training/methods MH - Adolescent MH - Young Adult PMC - PMC12991259 COIS- The authors have declared that no competing interests exist. EDAT- 2026/03/16 21:57 MHDA- 2026/03/16 21:58 PMCR- 2026/03/16 CRDT- 2026/03/16 13:23 PHST- 2025/09/16 00:00 [received] PHST- 2026/02/07 00:00 [accepted] PHST- 2026/03/16 21:58 [medline] PHST- 2026/03/16 21:57 [pubmed] PHST- 2026/03/16 13:23 [entrez] PHST- 2026/03/16 00:00 [pmc-release] AID - PONE-D-25-48676 [pii] AID - 10.1371/journal.pone.0343594 [doi] PST - epublish SO - PLoS One. 2026 Mar 16;21(3):e0343594. doi: 10.1371/journal.pone.0343594. eCollection 2026. PMID- 41836647 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260316 LR - 20260921 IS - 2398-502X (Print) IS - 2398-502X (Electronic) IS - 2398-502X (Linking) VI - 10 DP - 2025 TI - Untargeted metabolomics data in the By-Band-Sleeve trial and ALSPAC: integrating clinical trial and population cohort data. PG - 632 LID - 10.12688/wellcomeopenres.24917.2 [doi] LID - 632 AB - INTRODUCTION: Metabolomics is the study of measured metabolites and low-molecular weight molecules in a biological specimen, collectively known as the metabolome. Measuring the metabolome in populations is useful for investigating complex, polygenic and multifactorial traits as it can give insight into cellular metabolism and its perturbations in various states of health and disease. Here we present a description of metabolomics data generated using an untargeted mass-spectrometry approach in two studies: (1) the Avon Longitudinal Study of Parents and Children (ALSPAC) - a healthy, general population; and (2) the By-Band-Sleeve trial (BBS) - a pragmatic randomised controlled trial (RCT) of metabolic and bariatric surgery (MBS) plus a non-randomised observational sub-study. METHODS: Samples for this work were collected from ALSPAC participants at 30 years of age. Two sample collection efforts were made within BBS - firstly, from the RCT comparing the effectiveness of three types of MBS: the Roux-en-Y gastric bypass ("bypass"), laparoscopic adjustable gastric band ("band") and the sleeve gastrectomy ("sleeve"), and secondly from the non-randomised (observational) study of MBS. In both instances, samples were collected from patients before and after surgery. In total, 2128 samples were sent for mass-spectrometry (MS) metabolomics analysis by Metabolon (Discovery HD4 platform). Data underwent quality control (QC) via a standard pipeline using the R package metaboprep. RESULTS: After QC, the combined dataset consists of semi-quantitative data for 1176 features in 517 ALSPAC participants and 1062 BBS participants (1018 from the RCT and 44 from the non-randomised study) (1013 pre-surgery samples and 421 post-surgery samples). CONCLUSION: Overall, we have provided a summary of MS data produced across two different study populations, described the QC procedures undertaken and provided some data validation analyses. Bringing together samples from these two studies in a single experiment offers a novel study design able to explore the biological implications of weight and intentional weight loss. CI - Copyright: (c) 2026 Smith M et al. FAU - Smith, Madeleine AU - Smith M AD - Population Health Sciences, University of Bristol, Bristol, England, UK. AD - MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England, UK. FAU - Goudswaard, Lucy AU - Goudswaard L AD - Population Health Sciences, University of Bristol, Bristol, England, UK. AD - MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England, UK. FAU - Hughes, David AU - Hughes D AD - Population and Public Health Sciences, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA. FAU - Blazeby, Jane AU - Blazeby J AUID- ORCID: 0000-0002-3354-3330 AD - Population Health Sciences and Bristol Biomedical Research Centre, University of Bristol, Bristol, UK. AD - University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, England, UK. FAU - Rogers, Chris AU - Rogers C AUID- ORCID: 0000-0002-9624-2615 AD - Bristol Medical School, University of Bristol, Bristol, UK. FAU - Mazza, Graziella AU - Mazza G AD - Bristol Medical School, University of Bristol, Bristol, UK. FAU - Gidman, Eleanor AU - Gidman E AD - Bristol Medical School, University of Bristol, Bristol, UK. FAU - FitzGibbon, Sophie AU - FitzGibbon S AD - Population Health Sciences, University of Bristol, Bristol, England, UK. FAU - Groom, Alix AU - Groom A AD - Population Health Sciences, University of Bristol, Bristol, England, UK. AD - MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England, UK. FAU - Ring, Susan AU - Ring S AUID- ORCID: 0000-0003-3103-9330 AD - Population Health Sciences, University of Bristol, Bristol, England, UK. AD - MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England, UK. FAU - Northstone, Kate AU - Northstone K AUID- ORCID: 0000-0002-0602-1983 AD - Population Health Sciences, University of Bristol, Bristol, England, UK. FAU - Matthews, Sarah AU - Matthews S AUID- ORCID: 0009-0001-0525-1744 AD - Population Health Sciences, University of Bristol, Bristol, England, UK. FAU - White, Gail AU - White G AUID- ORCID: 0009-0006-5455-5337 AD - Population Health Sciences, University of Bristol, Bristol, England, UK. FAU - Fabian, Laurie AU - Fabian L AUID- ORCID: 0009-0007-3145-5357 AD - Population Health Sciences, University of Bristol, Bristol, England, UK. FAU - Timpson, Nicholas AU - Timpson N AUID- ORCID: 0000-0002-7141-9189 AD - Population Health Sciences, University of Bristol, Bristol, England, UK. AD - MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England, UK. FAU - Corbin, Laura AU - Corbin L AUID- ORCID: 0000-0002-4032-9500 AD - Population Health Sciences, University of Bristol, Bristol, England, UK. AD - MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England, UK. LA - eng GR - WT_/Wellcome Trust/United Kingdom PT - Journal Article DEP - 20260304 PL - England TA - Wellcome Open Res JT - Wellcome open research JID - 101696457 PMC - PMC12982984 OTO - NOTNLM OT - ALSPAC OT - By-Band-Sleeve OT - Metabolon OT - bariatric surgery OT - body mass index OT - mass-spectrometry OT - metabolic surgery OT - metabolomics OT - obesity COIS- No competing interests were disclosed. EDAT- 2026/03/16 21:56 MHDA- 2026/03/16 21:57 PMCR- 2026/03/04 CRDT- 2026/03/16 06:09 PHST- 2026/02/10 00:00 [accepted] PHST- 2026/03/16 21:57 [medline] PHST- 2026/03/16 21:56 [pubmed] PHST- 2026/03/16 06:09 [entrez] PHST- 2026/03/04 00:00 [pmc-release] AID - 10.12688/wellcomeopenres.24917.2 [doi] PST - epublish SO - Wellcome Open Res. 2026 Mar 4;10:632. doi: 10.12688/wellcomeopenres.24917.2. eCollection 2025. PMID- 41833363 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1753-4666 (Electronic) IS - 1753-4658 (Print) IS - 1753-4658 (Linking) VI - 20 DP - 2026 Jan-Dec TI - Optimizing clinical strategies for nutritional and immune indices prediction of chronic lung diseases: a cross-sectional study from NHANES 2007-2012. PG - 17534666261432503 LID - 10.1177/17534666261432503 [doi] LID - 17534666261432503 AB - BACKGROUND: Composite nutritional and immune indices (NIIs) have been associated with chronic lung diseases (CLDs). However, systematic research on their associations with different CLD subtypes and potential threshold patterns remains limited. OBJECTIVES: To examine cross-sectional associations between multiple NII and CLD subtypes, and to explore potential linear/nonlinear relationships and threshold ranges using a representative dataset. DESIGN: Cross-sectional, population-based study using National Health and Nutrition Examination Survey (NHANES) data. METHODS: Data were obtained from the US NHANES from 2007 to 2012. Participants aged 18-79 years with complete blood and baseline data were included. Survey-weighted regression models were used to assess associations between NIIs and CLDs. Restricted cubic spline (RCS) regression models were employed to explore linear/nonlinear relationships and potential threshold ranges. RESULTS: The study included 5837 participants (mean age 49.82 +/- 16.15). Regression analyses revealed significant associations between NIIs and CLDs across different ranges. RCS analysis identified thresholds for each NII: prognostic nutritional index (PNI) levels > 46.04 showed a significant inverse association with emphysema and chronic bronchitis. Elevated platelet-to-lymphocyte ratio (PLR) (>113.57) and MLR (>0.14) were positively associated with these conditions. systemic immune-inflammation index (SII) (>429.43) and neutrophil-to-lymphocyte ratio (NLR) (>0.99) were associated with a higher prevalence of asthma, emphysema, and chronic bronchitis. CONCLUSION: In this cross-sectional population-based study, NIIs were associated with different CLD subtypes, with evidence of potential threshold patterns. These findings may help inform future epidemiological studies and hypothesis generation, while causal inference and clinical application require further longitudinal validation. FAU - He, Song AU - He S AD - Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Chen, Cong AU - Chen C AD - Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Hao, Jianqi AU - Hao J AD - Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Shu, Yueli AU - Shu Y AD - Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Yu, Cheng AU - Yu C AD - Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Liu, Xiaojun AU - Liu X AD - Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Wu, Xiaoqing AU - Wu X AD - Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Luo, Nanzhi AU - Luo N AD - Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Zhou, Wenjing AU - Zhou W AD - Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Zha, Zhengyu AU - Zha Z AD - Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, No.37, Guoxue Valley, Wuhou District, Chengdu, Sichuan 610041, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260315 PL - England TA - Ther Adv Respir Dis JT - Therapeutic advances in respiratory disease JID - 101316317 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Middle Aged MH - Adult MH - Nutrition Surveys MH - Male MH - Aged MH - Adolescent MH - *Nutritional Status MH - United States/epidemiology MH - Young Adult MH - *Lung Diseases/immunology/physiopathology/epidemiology/diagnosis MH - Chronic Disease MH - Predictive Value of Tests MH - *Nutrition Assessment PMC - PMC13009673 OAB - Nutritional and immune indices in chronic lung disease: NHANES 2007-2012Chronic lung diseases (CLDs) like asthma, emphysema, and chronic bronchitis are major health issues. In this study, we explored the association between nutritional and immune indices (NIIs) and CLDs. These indices measure a person's nutrition and immune function. We analyzed data from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2012, focusing on adults aged 18-79. We examined how different NIIs related to CLDs and identified key threshold values that could predict disease risk. Our results showed that higher levels of prognostic nutritional index (PNI) were linked to a lower risk of emphysema and chronic bronchitis. In contrast, higher levels of platelet-to-lymphocyte ratio (PLR) and MLR were associated with a higher risk of these diseases. Additionally, elevated levels of systemic immune-inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR) were connected to a greater risk of asthma, emphysema, and chronic bronchitis. More importantly, we clarified specific values and constructed a new predictive framework. This study provides a useful framework for predicting CLD risk based on simple measurements. It can help doctors detect these diseases early and improve prevention and treatment strategies for patients. OABL- eng OTO - NOTNLM OT - National Health and Nutrition Examination Survey OT - asthma OT - chronic obstructive OT - inflammation OT - pulmonary disease COIS- The authors declare that there is no conflict of interest. EDAT- 2026/03/16 00:30 MHDA- 2026/03/16 00:31 PMCR- 2026/03/15 CRDT- 2026/03/15 21:22 PHST- 2026/03/16 00:31 [medline] PHST- 2026/03/16 00:30 [pubmed] PHST- 2026/03/15 21:22 [entrez] PHST- 2026/03/15 00:00 [pmc-release] AID - 10.1177_17534666261432503 [pii] AID - 10.1177/17534666261432503 [doi] PST - ppublish SO - Ther Adv Respir Dis. 2026 Jan-Dec;20:17534666261432503. doi: 10.1177/17534666261432503. Epub 2026 Mar 15. PMID- 41833281 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260711 IS - 1525-5069 (Electronic) IS - 1525-5050 (Linking) VI - 179 DP - 2026 Jun TI - Eating behavior problems in children with epilepsy (6-16 years): A cross-sectional comparative study. PG - 110987 LID - S1525-5050(26)00108-3 [pii] LID - 10.1016/j.yebeh.2026.110987 [doi] AB - OBJECTIVE: The aim of this study was to evaluate the risk of eating behavior disorders in children and adolescents aged 6-16 years diagnosed with epilepsy, and to compare this risk with that of healthy controls without epilepsy, in order to elucidate the impact of epilepsy on eating behaviors. MATERIALS AND METHODS: The study included 78 patients diagnosed with epilepsy who presented to the Pediatric Neurology Outpatient Clinic of Balikesir University Health Practice and Research Hospital between November 1, 2024 and January 1, 2025, along with 62 age-matched healthy controls without epilepsy and with normal neurological examinations. The diagnosis of epilepsy was established according to the International League Against Epilepsy (ILAE) criteria. Both groups completed the validated Turkish version of the Children's Eating Behaviour Questionnaire (CEBQ). Clinical characteristics of the epilepsy group, including age, sex, seizure type, epilepsy duration, seizure frequency and antiseizure medications (ASMs) use, were also evaluated. RESULTS: No statistically significant differences in eating behavior scores were observed between children with epilepsy and healthy controls (p > 0,05). Furthermore, eating behavior was not significantly associated with epilepsy duration, seizure type or antiseizure medication use. When the epilepsy group was examined within itself, differences in eating behavior were observed between genders. (p < 0,05). CONCLUSION: In this study, eating behaviors assessed by the CEBQ didn't different between children with epilepsy and healthy controls, nor were they associated with epilepsy-related clinical characteristics. However, gender-related changes in eating behavior have been observed in the epilepsy group. Large-scale studies are needed to investigate this situation. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Aycan, Ozlem Kemer AU - Aycan OK AD - Department of Pediatrics, Faculty of Medicine, Balikesir University, Balikesir, Turkiye. Electronic address: ozlem.aycan@balikesir.edu.tr. FAU - Aydin, Hilal AU - Aydin H AD - Department of Pediatric Neurology, Faculty of Medicine, Balikesir University, Balikesir, Turkiye. Electronic address: drhilalaydin@gmail.com. FAU - Tulaci, Ozge Demircan AU - Tulaci OD AD - Department of Child and Adolescent Psychiatry, Balikesir University, Balikesir, Turkiye. Electronic address: ozgedemircantulaci@gmail.com. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260314 PL - United States TA - Epilepsy Behav JT - Epilepsy & behavior : E&B JID - 100892858 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - Adolescent MH - *Epilepsy/complications/psychology/epidemiology MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - *Feeding and Eating Disorders/etiology/epidemiology MH - *Feeding Behavior MH - Turkey OTO - NOTNLM OT - Eating Behavior OT - Epilepsy OT - Pediatric Population COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/03/16 00:29 MHDA- 2026/04/11 00:32 CRDT- 2026/03/15 19:26 PHST- 2025/09/29 00:00 [received] PHST- 2026/02/28 00:00 [revised] PHST- 2026/03/01 00:00 [accepted] PHST- 2026/04/11 00:32 [medline] PHST- 2026/03/16 00:29 [pubmed] PHST- 2026/03/15 19:26 [entrez] AID - S1525-5050(26)00108-3 [pii] AID - 10.1016/j.yebeh.2026.110987 [doi] PST - ppublish SO - Epilepsy Behav. 2026 Jun;179:110987. doi: 10.1016/j.yebeh.2026.110987. Epub 2026 Mar 14. PMID- 41832256 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Mar 14 TI - Standardizing oral microbiome sampling for qPCR: methodological and exploratory insights into nutritional status. LID - 10.1038/s41598-026-43909-7 [doi] LID - 13501 AB - Standardization of oral sample collection methods is essential for accurate and reproducible microbiota quantification. This methodological study aimed to evaluate different oral collection methods to identify the most consistent approach for bacterial quantification by qPCR using samples from adolescent individuals. In addition, to assess the biological applicability of the best method, an exploratory analysis compared bacterial profiles between eutrophic and overweight/obese adolescents and explored associations between bacterial abundance and body composition parameters. Samples of unstimulated saliva, cheek swabs, and biofilm were collected from the same individuals, and qPCR was used to quantify total bacteria (16 S rRNA gene), Bacillota, and Bacteroidota phyla. Unstimulated saliva produced the lowest variability in bacterial quantification compared with other methods (p < 0.05). Moderate correlations were observed between saliva and biofilm, whereas saliva and cheek swab showed weak associations. Although bacterial copy numbers tended to be higher in overweight/obese individuals, these differences were not statistically significant. Correlation matrices suggested group-specific associations between bacterial taxa and body composition parameters, demonstrating the potential of saliva for microbiome assessment in studies of nutritional and metabolic health. This study validated unstimulated saliva as a reproducible, non-invasive, and cost-effective biofluid for oral microbiota quantification by qPCR. The method provides consistent results suitable for large-scale, translational, or point-of-care applications. CI - (c) 2026. The Author(s). FAU - Mendes, Karina AU - Mendes K AD - Center for Interdisciplinary Research in Health (CIIS), Faculty of Dental Medicine (FMD), Universidade Catolica Portuguesa, Estrada da Circunvalacao, 3504-505, Viseu, Portugal. FAU - Gomes, Ana T P C AU - Gomes ATPC AD - Center for Interdisciplinary Research in Health (CIIS), Faculty of Dental Medicine (FMD), Universidade Catolica Portuguesa, Estrada da Circunvalacao, 3504-505, Viseu, Portugal. FAU - Resende, Cristina Maria Mendes AU - Resende CMM AD - Graduate Program in Hebiatria, University of Pernambuco, Recife, Brazil. FAU - Ribeiro, Isabela S AU - Ribeiro IS AD - Graduate Program in Molecular and Cell Biology, University of Pernambuco, Recife, Brazil. FAU - Oliveira, Rafael M C AU - Oliveira RMC AD - Laboratory of Molecular Biology, Hospital Universitario Oswaldo Cruz, University of Pernambuco, Recife, Brazil. FAU - Rosa, Nuno AU - Rosa N AD - Center for Interdisciplinary Research in Health (CIIS), Faculty of Dental Medicine (FMD), Universidade Catolica Portuguesa, Estrada da Circunvalacao, 3504-505, Viseu, Portugal. FAU - Muniz, Maria T C AU - Muniz MTC AD - Graduate Program in Molecular and Cell Biology, University of Pernambuco, Recife, Brazil. FAU - Correia, Maria J AU - Correia MJ AD - Center for Interdisciplinary Research in Health (CIIS), Faculty of Dental Medicine (FMD), Universidade Catolica Portuguesa, Estrada da Circunvalacao, 3504-505, Viseu, Portugal. mcorreia@ucp.pt. LA - eng GR - CEECINST/00070/2021-CIIS-Junior/Fundacao para a Ciencia e a Tecnologia/ GR - UID/04279/2025 and DOI identifier https://doi.org/10.54499/UID/04279/2025 - Centro de Investigacao Interdisciplinar em Saude/Fundacao para a Ciencia e a Tecnologia/ GR - CAPES - Finance code 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ PT - Journal Article DEP - 20260314 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (RNA, Ribosomal, 16S) SB - IM MH - Humans MH - *Microbiota/genetics MH - *Saliva/microbiology MH - Female MH - Adolescent MH - *Mouth/microbiology MH - *Nutritional Status MH - *Real-Time Polymerase Chain Reaction/methods/standards MH - RNA, Ribosomal, 16S/genetics MH - Male MH - Bacteria/genetics/classification MH - *Specimen Handling/methods/standards PMC - PMC13111650 OTO - NOTNLM OT - Bacillota OT - Bacteroidota OT - Oral microbiome OT - QPCR OT - Saliva OT - Sampling methodology COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Ethics Committee of the Instituto de Ciencias Biologicas, Universidade de Pernambuco (Approval number: 4.865.118; CAAE: 42220719.6.0000.5207). The study was conducted in accordance with the Declaration of Helsinki. Written informed consent was obtained from the legal guardians of all participants included in this study. Competing interests: The authors declare no competing interests. EDAT- 2026/03/15 06:48 MHDA- 2026/04/27 00:30 PMCR- 2026/03/14 CRDT- 2026/03/15 00:16 PHST- 2025/12/22 00:00 [received] PHST- 2026/03/09 00:00 [accepted] PHST- 2026/04/27 00:30 [medline] PHST- 2026/03/15 06:48 [pubmed] PHST- 2026/03/15 00:16 [entrez] PHST- 2026/03/14 00:00 [pmc-release] AID - 10.1038/s41598-026-43909-7 [pii] AID - 43909 [pii] AID - 10.1038/s41598-026-43909-7 [doi] PST - epublish SO - Sci Rep. 2026 Mar 14;16(1):13501. doi: 10.1038/s41598-026-43909-7. PMID- 41831651 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 1541-6100 (Electronic) IS - 0022-3166 (Print) IS - 0022-3166 (Linking) VI - 156 IP - 5 DP - 2026 May TI - Location-Specific Predictors of Double Burden of Malnutrition among Nigerian Mother-Child Pairs: Re-evaluating Dietary Quality and Socioeconomic Factors. PG - 101478 LID - S0022-3166(26)00127-6 [pii] LID - 10.1016/j.tjnut.2026.101478 [doi] LID - 101478 AB - BACKGROUND: The double burden of malnutrition (DBM), classified as the coexistence of maternal overweight/obesity or maternal undernutrition and child undernutrition or childhood overweight/obesity, within the same household, is an increasing concern in Nigeria. Drivers of DBM may differ by location due to urbanization, socioeconomic gradients, and dietary transitions. OBJECTIVES: This study examined location-specific predictors of DBM among Nigerian mother-child pairs, with a focus on child dietary quality, maternal education, household food insecurity, and wealth index. METHODS: A descriptive cross-sectional study using a stratified multistage sampling technique was conducted among 1295 mother-child pairs (children aged 6-23 mo) across 4 Nigerian cities. Child nutritional status was assessed using World Health Organization (WHO) growth standards, and maternal body mass index was classified according to WHO adult cutoffs. Household food insecurity, dietary diversity, minimum meal frequency, and wealth index were measured using validated tools. Associations between predictors and DBM were examined using chi(2) tests and generalized estimating equations, including interaction and stratified analyses by location. RESULTS: DBM prevalence was 37.4%, with the most frequent phenotype being overweight mothers and undernourished children (34%). Semiurban residence [adjusted odds ratio (AOR): 2.11; 95% confidence interval (CI): 1.93, 2.30], food-secure households (AOR: 1.22; 95% CI: 1.09, 1.37), and not meeting the minimum meal frequency (AOR: 1.41; 95% CI: 1.04, 1.92) were associated with an increased risk of DBM. CONCLUSIONS: DBM among Nigerian mother-child pairs is shaped by dietary factors. Context-specific interventions are needed, with a focus on improving child diet quality in semiurban areas. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Ortutu, Beulah F AU - Ortutu BF AD - Department of Nutrition, Texas A&M University, TX, United States; Department of Human Nutrition and Dietetics, Michael Okpara University of Agriculture, Umudike, Nigeria. Electronic address: beulah@tamu.edu. FAU - Adeleke, Faidat A AU - Adeleke FA AD - Department of Human Nutrition and Dietetics, University of Ibadan, Ibadan, Nigeria. FAU - Idris, Hajara AU - Idris H AD - Department of Pediatrics, Federal Teaching Hospital Katsina, Katsina, Nigeria. FAU - Ezenwa, Chiamaka J AU - Ezenwa CJ AD - Department of Public Health, Federal University of Technology, Owerri, Nigeria. FAU - Adeleke, Folasade A AU - Adeleke FA AD - Department of Nutrition and Dietetics, Modibbo Adama University Teaching Hospital, Yola, Nigeria. FAU - Nwonye, Okemudi AU - Nwonye O AD - Department of Nutrition and Dietetics, Federal University of Agriculture, Mubi, Nigeria. FAU - Edafioghor, Linda O AU - Edafioghor LO AD - Department of Nutrition and Dietetics, Federal University of Medical and Health Science, Kwale, Delta state, Nigeria. FAU - Egechizuorom, Ifeoma M AU - Egechizuorom IM AD - Department of Nutrition and Dietetics, Federal Medical Centre, Umuahia, Nigeria. FAU - Iheme, Gideon O AU - Iheme GO AD - Department of Human Nutrition and Dietetics, Michael Okpara University of Agriculture, Umudike, Nigeria; Department of Food Studies, Nutrition and Dietetics, Uppsala University, Uppsala, Sweden. LA - eng PT - Journal Article DEP - 20260312 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 SB - IM MH - Humans MH - Nigeria/epidemiology MH - Female MH - Cross-Sectional Studies MH - *Socioeconomic Factors MH - *Malnutrition/epidemiology MH - *Diet MH - Infant MH - Mothers MH - Food Insecurity MH - Male MH - Adult MH - Nutritional Status MH - Prevalence PMC - PMC13197940 OTO - NOTNLM OT - Nigeria OT - diet quality OT - double burden of malnutrition (DBM) OT - food insecurity OT - maternal education OT - mother-child pairs OT - wealth index COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/03/15 05:36 MHDA- 2026/05/09 00:34 PMCR- 2026/03/12 CRDT- 2026/03/14 20:13 PHST- 2025/10/14 00:00 [received] PHST- 2025/12/30 00:00 [revised] PHST- 2026/03/09 00:00 [accepted] PHST- 2026/05/09 00:34 [medline] PHST- 2026/03/15 05:36 [pubmed] PHST- 2026/03/14 20:13 [entrez] PHST- 2026/03/12 00:00 [pmc-release] AID - S0022-3166(26)00127-6 [pii] AID - 101478 [pii] AID - 10.1016/j.tjnut.2026.101478 [doi] PST - ppublish SO - J Nutr. 2026 May;156(5):101478. doi: 10.1016/j.tjnut.2026.101478. Epub 2026 Mar 12. PMID- 41831324 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260917 IS - 1099-1077 (Electronic) IS - 0885-6222 (Print) IS - 0885-6222 (Linking) VI - 41 IP - 2 DP - 2026 Mar TI - Developing a Polygenic Risk Score for Weight Gain in People Treated for Psychosis-Application in a Real-World Setting. PG - e70035 LID - 10.1002/hup.70035 [doi] LID - e70035 AB - INTRODUCTION: Genetic factors are thought to play an important role in antipsychotic-induced weight gain (AIWG). Polygenic risk scores (PRS) could provide a measure of genetic predisposition to antipsychotic drug induced weight gain (AIWG).We conducted a study to examine how a PRS, generated using SNPs, identified from a recent meta-analysis, related to weight-change over time in people with first episode-psychosis. METHODS: The PRS included SNPs in six different genes, identified as having significant associations (p < 0.05) with AIWG. These were HTR2C rs3813929; MTHFR rs1801133; ADRA2A rs1800544; MC4R rs489693; LEPR rs1137101 and CNR1 rs1049353. An additive PRS and a risk allele based weighted PRS were created based on risk allele counts and presence or absence of risk alleles respectively. The additive PRS was also used to create low/high genetic risk groups for analysis. The association between PRS and weight gain per day (WGPD) in grams/day as well as BMI percentage change (=> 7%) was investigated using regression models. RESULTS: In multiple regression analysis, the additive PRS significantly predicted AIWG in females (adjusted r(2) = 0.59, B: unstandardised regression coefficient = 24.4 g/day p < 0.05), but not in males. ANCOVA showed that high genetic risk groups had greater WGPD (p = 0.018), with significant PRS gender interactions driven by markedly higher WGPD in high-risk females (p = 0.039). None of the models tested were associated with BMI percentage change. CONCLUSION: We report a PRS that is predictive of weight gain in women treated for first episode psychosis, accounting for 59% of the variance daily weight-gain over time. Validation in an independent cohort is required, as is determining whether it is feasible to apply the PRS prospectively. CI - (c) 2026 The Author(s). Human Psychopharmacology: Clinical and Experimental published by John Wiley & Sons Ltd. FAU - Heald, Adrian AU - Heald A AUID- ORCID: 0000-0002-9537-4050 AD - Department of Endocrinology and Diabetes, Salford Royal Hospital, Salford, UK. AD - The School of Medicine and Manchester Academic Health Sciences Centre, Manchester University, Manchester, UK. FAU - Illangasekera, Yasitha AU - Illangasekera Y AD - Sheffield Hallam University, Biomolecular Sciences Research Centre, Sheffield, UK. AD - Department of Pharmacology, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka. FAU - Loureiro, Camila Marcelino AU - Loureiro CM AD - Sheffield Hallam University, Biomolecular Sciences Research Centre, Sheffield, UK. FAU - Shakespeare, Mark AU - Shakespeare M AD - Rotherham, Doncaster and South Humber NHS Foundation, Doncaster, UK. FAU - Jameson, Adam AU - Jameson A AD - School of Pharmacy and Medical Sciences, University of Bradford, Bradford, UK. AD - Department of Pharmacy, Bradford District Care NHS Foundation Trust, Bradford, UK. FAU - Phillipson, Adrian AU - Phillipson A AD - Rotherham, Doncaster and South Humber NHS Foundation, Doncaster, UK. FAU - Reynolds, Gavin P AU - Reynolds GP AD - Sheffield Hallam University, Biomolecular Sciences Research Centre, Sheffield, UK. AD - Rotherham, Doncaster and South Humber NHS Foundation, Doncaster, UK. FAU - Dalton, Caroline AU - Dalton C AD - Sheffield Hallam University, Biomolecular Sciences Research Centre, Sheffield, UK. LA - eng PT - Journal Article PL - England TA - Hum Psychopharmacol JT - Human psychopharmacology JID - 8702539 RN - 0 (Antipsychotic Agents) RN - 0 (ADRA2A protein, human) RN - EC 1.5.1.20 (MTHFR protein, human) RN - 0 (MC4R protein, human) RN - 0 (LEPR protein, human) RN - 0 (CNR1 protein, human) RN - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2)) RN - 0 (Receptor, Serotonin, 5-HT2C) RN - 0 (Receptor, Melanocortin, Type 4) RN - 0 (Receptors, Adrenergic, alpha-2) RN - 0 (Receptor, Cannabinoid, CB1) RN - 0 (Receptors, Leptin) SB - IM MH - Humans MH - *Weight Gain/drug effects/genetics MH - Female MH - Genetic Risk Score MH - *Antipsychotic Agents/adverse effects/therapeutic use MH - *Psychotic Disorders/drug therapy/genetics MH - Polymorphism, Single Nucleotide MH - Male MH - Adult MH - Genetic Predisposition to Disease MH - Methylenetetrahydrofolate Reductase (NADPH2)/genetics MH - Receptor, Serotonin, 5-HT2C/genetics MH - Young Adult MH - Receptor, Melanocortin, Type 4/genetics MH - *Multifactorial Inheritance MH - Adolescent MH - Receptors, Adrenergic, alpha-2 MH - Receptor, Cannabinoid, CB1 MH - Receptors, Leptin PMC - PMC12988834 OTO - NOTNLM OT - antipsychotic OT - association OT - gene OT - polygenic risk score OT - psychosis OT - weight gain COIS- The authors declare no conflicts of interest. EDAT- 2026/03/15 05:36 MHDA- 2026/03/15 05:37 PMCR- 2026/03/14 CRDT- 2026/03/14 15:43 PHST- 2026/02/05 00:00 [revised] PHST- 2025/11/21 00:00 [received] PHST- 2026/02/25 00:00 [accepted] PHST- 2026/03/15 05:37 [medline] PHST- 2026/03/15 05:36 [pubmed] PHST- 2026/03/14 15:43 [entrez] PHST- 2026/03/14 00:00 [pmc-release] AID - HUP70035 [pii] AID - 10.1002/hup.70035 [doi] PST - ppublish SO - Hum Psychopharmacol. 2026 Mar;41(2):e70035. doi: 10.1002/hup.70035. PMID- 41831190 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Mar 14 TI - Perfectionism, obsessive-compulsive symptoms, and health-thinness-cleanliness motivations as primary correlates of orthorexia nervosa. LID - 10.1007/s40519-026-01823-x [doi] LID - 49 AB - PURPOSE: Orthorexia Nervosa (ON) is characterized by an obsessive preoccupation with eating foods perceived as healthy or clean. Despite growing research interest, risk factors and underlying motivations for ON remain poorly understood. This study examined demographic factors, psychological correlates, and dietary motivations associated with ON symptomatology, building on McComb and Mills' (2019) theoretical model. METHODS: Participants (N = 697) completed validated measures of ON, alongside assessments of demographic factors (age, gender, socioeconomic status, dietary means), psychological variables (perfectionism, obsessive-compulsive symptoms, perceived control, perceived vulnerability to disease, past eating disorder diagnosis), and dietary motivations (thinness, health, cleanliness, muscularity, feeling mentally well). RESULTS: Three dietary motivations: desires to be thin, healthy, and clean were significantly associated with ON symptoms across both measures. Perfectionism (specifically perfectionistic striving) and obsessive-compulsive symptoms (particularly the 'washing' subscale reflecting contamination concerns) emerged as the strongest psychological predictors of ON symptomatology. Demographic variables (age, gender, socioeconomic status) were not associated with ON symptoms, although lower perceived dietary means was associated with higher ON symptomatology. Results were largely replicated using both ON scales. CONCLUSION: ON appears driven by perfectionist striving and contamination-related obsessive-compulsive symptoms, alongside complex motivations that extend beyond health to also include thinness and cleanliness concerns. These findings suggest that ON represents a convergence of multiple motivational domains and highlights potential targets for intervention, including perfectionism-based and exposure-response prevention approaches adapted from obsessive-compulsive disorder and eating disorders treatments. LEVEL OF EVIDENCE: Level V, based on a descriptive study. CI - (c) 2026. The Author(s). FAU - Greville-Harris, Maddy AU - Greville-Harris M AD - Department of Psychology, Washington Singer Laboratories, Health and Life Sciences, University of Exeter, Exeter, EX4 4QG, UK. m.l.greville-harris@exeter.ac.uk. FAU - Vuillier, Laura AU - Vuillier L AD - Department of Psychology Faculty of Science and Technology, Bournemouth University, Poole, BH12 5BB, UK. FAU - Talbot, Catherine AU - Talbot C AD - Department of Psychology Faculty of Science and Technology, Bournemouth University, Poole, BH12 5BB, UK. FAU - Appleton, Katherine AU - Appleton K AD - Department of Psychology Faculty of Science and Technology, Bournemouth University, Poole, BH12 5BB, UK. LA - eng PT - Journal Article DEP - 20260314 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - Female MH - *Perfectionism MH - *Feeding and Eating Disorders/psychology MH - *Motivation/physiology MH - *Obsessive-Compulsive Disorder/psychology MH - Adult MH - Male MH - Young Adult MH - *Thinness/psychology MH - Adolescent MH - *Feeding Behavior/psychology MH - *Obsessive Behavior/psychology PMC - PMC13219126 OTO - NOTNLM OT - Dietary motivations OT - Disordered eating OT - Obsessive-compulsive symptoms OT - Orthorexia nervosa OT - Perfectionism COIS- Declarations. Ethics approval and consent to participate: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Bournemouth University (Ethics number: 39332). Informed consent was obtained from all participants included in the study. Consent for publication: Consent to publish has been received from all participants in this study. Competing interests: The authors declare no competing interests. EDAT- 2026/03/15 05:36 MHDA- 2026/05/29 15:46 PMCR- 2026/03/14 CRDT- 2026/03/14 12:19 PHST- 2025/08/12 00:00 [received] PHST- 2026/02/04 00:00 [accepted] PHST- 2026/05/29 15:46 [medline] PHST- 2026/03/15 05:36 [pubmed] PHST- 2026/03/14 12:19 [entrez] PHST- 2026/03/14 00:00 [pmc-release] AID - 10.1007/s40519-026-01823-x [pii] AID - 1823 [pii] AID - 10.1007/s40519-026-01823-x [doi] PST - epublish SO - Eat Weight Disord. 2026 Mar 14;31(1):49. doi: 10.1007/s40519-026-01823-x. PMID- 41829927 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 5 DP - 2026 Feb 26 TI - From Traits to Clusters: Emotional-Sensory-Regulatory Eating Profiles in Generation Z with Implications in Sustainable Food Behavior. LID - 10.3390/nu18050758 [doi] LID - 758 AB - BACKGROUND: Building on our previous systematic review that synthesized eight core sustainable appetitive traits central to food behavior research, the present study extends this framework through an empirical investigation of Generation Z university students in Greece. We have established the conceptual foundation by mapping emotional, sensory, and behavioral regulation drivers of eating behavior, underscoring their relevance for nutrition and sustainability. However, empirical applications of this multidimensional framework to Generation Z remained scarce. OBJECTIVES: This study addresses this gap by examining eating behaviors among approximately 800 students at the University of Ioannina using a validated post-pandemic questionnaire. METHODS & RESULTS: Results revealed heterogeneity across six domains, with consensus observed only in sensory-driven eating (M = 3.88) and openness to new foods (M = 4.00). Cluster analysis identified two distinct profiles: Exploratory and Hedonic Responders and Emotionally Regulated and Satiety-Oriented Responders. These clusters delineate a novel profile of Generation Z, portraying them as digitally immersed, sustainability-oriented, and emotionally sensitive, yet divided between impulsive exploration and regulated satiety. CONCLUSIONS: The study contributes new empirical insights into post-pandemic food behavior. It establishes a comprehensive evidence base for designing culturally sensitive wellness programs and targeted nutritional interventions that support sustainable dietary practices. The continuity between the two papers underscores both theoretical importance and the practical necessity of integrating emotional, sensory, and regulatory dimensions in advancing sustainable eating futures among young adults. FAU - Koliou, Maria P AU - Koliou MP AUID- ORCID: 0009-0009-1751-5629 AD - Laboratory of Food Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece. FAU - Kouskoura, Amalia AU - Kouskoura A AD - Management of Technology Research Lab (Materlab), University of Western Macedonia, 50100 Kozani, Greece. FAU - Kontogeorgos, Achilleas AU - Kontogeorgos A AUID- ORCID: 0000-0002-4186-0379 AD - Department of Agriculture, International University of Greece, 57001 Thessaloniki, Greece. FAU - Skalkos, Dimitris AU - Skalkos D AUID- ORCID: 0000-0002-7771-2845 AD - Laboratory of Food Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece. LA - eng PT - Journal Article DEP - 20260226 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Feeding Behavior/psychology MH - Female MH - Male MH - Young Adult MH - Greece MH - *Emotions MH - Surveys and Questionnaires MH - Emotional Eating MH - Cluster Analysis MH - Students/psychology MH - Adult MH - Adolescent PMC - PMC12986968 OTO - NOTNLM OT - Generation Z OT - eating behavior clusters OT - emotional eating sensory cues OT - factorial and cluster analysis OT - public health interventions OT - satiety regulation COIS- The authors declare no conflicts of interest. EDAT- 2026/03/14 06:32 MHDA- 2026/03/14 06:33 PMCR- 2026/02/26 CRDT- 2026/03/14 01:11 PHST- 2026/02/04 00:00 [received] PHST- 2026/02/13 00:00 [revised] PHST- 2026/02/24 00:00 [accepted] PHST- 2026/03/14 06:33 [medline] PHST- 2026/03/14 06:32 [pubmed] PHST- 2026/03/14 01:11 [entrez] PHST- 2026/02/26 00:00 [pmc-release] AID - nu18050758 [pii] AID - nutrients-18-00758 [pii] AID - 10.3390/nu18050758 [doi] PST - epublish SO - Nutrients. 2026 Feb 26;18(5):758. doi: 10.3390/nu18050758. PMID- 41827647 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260314 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 5 DP - 2026 Mar 9 TI - Physical Literacy-Focused Education Improves Fitness Markers in Preadolescents: Implications for School-Based Health Promotion. LID - 10.3390/healthcare14050695 [doi] LID - 695 AB - BACKGROUND/OBJECTIVES: Physical literacy (PL) is globally recognized as a foundational determinant of health status in children, but the effects of interventions based on PL were rarely studied in preadolescent children. The aim of this quasi-experimental, school-based study was to evaluate the potential effects of a PL intervention delivered during regular school hours on physical fitness (PF), physical literacy (PL), and physical activity (PA) in children aged 9 to 11 years from southern Croatia. METHODS: Participants were 125 preadolescents (57 girls), and were grouped into a control group (C = 70), and an experimental group (E, n = 55). The E group participated in a specific PL-focused education, integrated into regular physical education (PE) lessons as a 5-6 min substitute for standard PE content, over 12 weeks (36 PE classes in total). The C group participated in the standard PE curriculum. A pre-post-retention design was used, and the observed variables included anthropometrics (height, weight, BMI), PF (jumping power, abdominal strength, upper body strength, flexibility, mobility, and cardiovascular endurance), PL (evaluated by the PLAYself questionnaire), and indirectly measured PA (estimated via the PAQ-C questionnaire). Multivariate (MANOVA and univariate (ANOVA) analyses of variance for repeated measurements were used with time, gender, and group as the main effects, including their interactions. RESULTS: MANOVA calculated for a set of PF variables revealed significant main effects for time (F = 1361, p < 0.001) and a significant time x group interaction (F = 2.98, p < 0.05). Univariate ANOVA indicated specific intervention effects for jumping power and abdominal strength, favoring the E group. No significant differential effects were observed for PL or PA. CONCLUSIONS: The study demonstrated small, but statistically significant, improvements in PF indicators among children exposed to the PL-based intervention. Notably, the intervention was conducted in authentic school settings using standard resources, supporting the ecological validity and real-world applicability of the findings. FAU - Rajkovic Vuletic, Petra AU - Rajkovic Vuletic P AUID- ORCID: 0009-0008-1726-8704 AD - Faculty of Kinesiology, University of Split, 21000 Split, Croatia. AD - Faculty of Kinesiology, University of Zagreb, 10000 Zagreb, Croatia. FAU - Pranjic, Tomislav AU - Pranjic T AUID- ORCID: 0009-0002-2418-3027 AD - Faculty of Kinesiology, University of Split, 21000 Split, Croatia. FAU - Gilic Skugor, Barbara AU - Gilic Skugor B AUID- ORCID: 0000-0002-8868-7315 AD - Faculty of Kinesiology, University of Split, 21000 Split, Croatia. FAU - Lesnik, Blaz AU - Lesnik B AUID- ORCID: 0000-0002-0006-0092 AD - Faculty of Sport, University of Ljubljana, 10000 Ljubljana, Slovenia. FAU - Sekulic, Damir AU - Sekulic D AUID- ORCID: 0000-0001-8022-7886 AD - Faculty of Kinesiology, University of Split, 21000 Split, Croatia. FAU - Sajber, Dorica AU - Sajber D AD - Faculty of Sport, University of Ljubljana, 10000 Ljubljana, Slovenia. LA - eng GR - UIP-2025-02-3974/Croatian Science Foundation/ PT - Journal Article DEP - 20260309 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12984826 OTO - NOTNLM OT - health promotion OT - motor activity OT - pediatrics OT - quasi-experimental studies COIS- The authors declare no conflicts of interest. EDAT- 2026/03/14 06:31 MHDA- 2026/03/14 06:32 PMCR- 2026/03/09 CRDT- 2026/03/14 01:02 PHST- 2026/01/09 00:00 [received] PHST- 2026/02/25 00:00 [revised] PHST- 2026/03/06 00:00 [accepted] PHST- 2026/03/14 06:32 [medline] PHST- 2026/03/14 06:31 [pubmed] PHST- 2026/03/14 01:02 [entrez] PHST- 2026/03/09 00:00 [pmc-release] AID - healthcare14050695 [pii] AID - healthcare-14-00695 [pii] AID - 10.3390/healthcare14050695 [doi] PST - epublish SO - Healthcare (Basel). 2026 Mar 9;14(5):695. doi: 10.3390/healthcare14050695. PMID- 41827589 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260314 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 5 DP - 2026 Mar 3 TI - Intergenerational Mealtimes in Adult Day Care Settings: Impact of a Pilot Randomised Control Study on the Well-Being, Health, and Food Intake of Older Adults. LID - 10.3390/healthcare14050635 [doi] LID - 635 AB - Background/Objectives: Empirical evidence on intergenerational commensality in institutional care settings remains scarce. This pilot and feasibility study evaluated the preliminary impact of an innovative intergenerational mealtime model on older adults' subjective well-being, self-esteem, perceived health, and food consumption in an adult day care setting. Methods: A 16-week wait-list randomised controlled pilot trial with a sequential explanatory mixed-methods design was conducted in an intergenerational centre in southern Spain. Twenty-two older adults who reside in a community living setting and attend a day care service were randomly assigned to two intergenerational dining intervention/waiting-list groups or a control group. Participants in the intervention/waiting-list groups had lunch four times per week with children 2-3 years of age, following a structured protocol. The quantitative outcomes examined included subjective well-being (WHO-5 Well-Being Index), self-esteem (Rosenberg scale), perceived health (EuroQol EQ-5D), and objective assessment of plate leftovers using photographic records and the Comstock visual estimation method. Qualitative data were collected through semi-structured interviews and ethnographic observation. The trial was registered at ClinicalTrials.gov (NCT06996418). Results: Across the study period, intervention, waiting-list, and control groups showed preliminary improvements in subjective well-being and self-esteem, but with no significant group-by-time interaction. In contrast, mixed-effects models revealed an encouraging significant reduction in plate leftovers among older adults during intergenerational meals, particularly in second courses. The reduction was consolidated during the post-intervention follow-up. Qualitative findings showed perceived improvements in emotional well-being, motivation, and appetite, thus highlighting potential relational and affective mechanisms underlying changes in eating behaviour. Conclusions: This pilot study shows promise for intergenerational commensality in adult day care settings and provides preliminary evidence of its potential to promote well-being and self-esteem and reduce food waste among older adults. Larger, multi-centre, appropriately powered trials are warranted to validate these findings. FAU - Lopez-Lopez, Raul AU - Lopez-Lopez R AD - Department of Sociology, University of Granada, 18071 Granada, Granada, Spain. FAU - Artacho, Reyes AU - Artacho R AUID- ORCID: 0000-0001-6405-9480 AD - Department of Nutrition and Food Science, Faculty of Pharmacy, University of Granada, 18071 Granada, Granada, Spain. FAU - Rodriguez-Perez, Celia AU - Rodriguez-Perez C AUID- ORCID: 0000-0002-7233-6481 AD - Department of Nutrition and Food Science, Faculty of Pharmacy, University of Granada, 18071 Granada, Granada, Spain. AD - Institute of Nutrition and Food Technology (INYTA) 'Jose Mataix', Biomedical Research Centre, University of Granada, Avda. del Conocimiento s/n, 18100 Granada, Granada, Spain. AD - Instituto de Investigacion Biosanitaria ibs. GRANADA, Avenida de Madrid, 15, 18012 Granada, Granada, Spain. FAU - Justicia-Garcia, Judith AU - Justicia-Garcia J AD - Nestle Espana S.A., 08950 Esplugues de Llobregat, Barcelona, Spain. FAU - Carrillo, Alicia AU - Carrillo A AD - Macrosad, Parque Cientifico y Tecnologico Geolit, Av. De la Innovacion, 3, 23260 Mengibar, Jaen, Spain. FAU - Sanchez, Mariano AU - Sanchez M AUID- ORCID: 0000-0002-1129-9525 AD - Department of Sociology, University of Granada, 18071 Granada, Granada, Spain. AD - Macrosad Chair in Intergenerational Studies, Faculty of Political Sciences and Sociology, University of Granada, 18071 Granada, Granada, Spain. LA - eng SI - ClinicalTrials.gov/NCT06996418 GR - OTRI-6474 "Intergenerational dining rooms: proof of concept, prototyping, small-scale piloting, and validation."/Nestle Espana S.A./ PT - Journal Article DEP - 20260303 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12984263 OTO - NOTNLM OT - intergenerational commensality OT - leftover food OT - mixed methods OT - older adults OT - perceived health OT - pilot randomised controlled trial OT - self-esteem OT - subjective well-being COIS- Alicia Carrillo is employed at Macrosad. Judith Justicia-Garcia is an employee of Nestle Espana S.A. However, it is declared that none of these coauthors were directly involved on study design, implementation, and interpretation. Both of them played the role of follow-up persons on behalf of funding stakeholders. Mariano Sanchez is an external scientific consultant to initiatives by Macrosad. Raul Lopez-Lopez, Reyes Artacho, and Celia Rodriguez declare no conflicts of interest. EDAT- 2026/03/14 06:33 MHDA- 2026/03/14 06:34 PMCR- 2026/03/03 CRDT- 2026/03/14 01:02 PHST- 2025/12/31 00:00 [received] PHST- 2026/02/24 00:00 [revised] PHST- 2026/02/28 00:00 [accepted] PHST- 2026/03/14 06:34 [medline] PHST- 2026/03/14 06:33 [pubmed] PHST- 2026/03/14 01:02 [entrez] PHST- 2026/03/03 00:00 [pmc-release] AID - healthcare14050635 [pii] AID - healthcare-14-00635 [pii] AID - 10.3390/healthcare14050635 [doi] PST - epublish SO - Healthcare (Basel). 2026 Mar 3;14(5):635. doi: 10.3390/healthcare14050635. PMID- 41827078 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 1749-799X (Electronic) IS - 1749-799X (Linking) VI - 21 IP - 1 DP - 2026 Mar 13 TI - Cross-education effects of healthy-side lower-limb strength training on neuromuscular function recovery following anterior cruciate ligament reconstruction: a randomized controlled trial. LID - 10.1186/s13018-026-06776-6 [doi] LID - 269 AB - OBJECTIVE: Based on cross-education theory, this study aimed to investigate whether Healthy-Side Lower-Limb Strength Training could promote neuromuscular function recovery of the injured limb in patients following anterior cruciate ligament reconstruction (ACLR) through central nervous system-mediated contralateral adaptive mechanisms. METHODS: A single-masked, randomized controlled trial was conducted with 40 patients at 5-6 weeks post-ACLR, who were randomly allocated to intervention and control groups (n = 20). The control group received conventional rehabilitation, while the intervention group received conventional rehabilitation plus Healthy-Side Lower-Limb Strength Training for 6 weeks. The Lysholm knee function score was used to assess knee joint function at baseline and post-intervention. A wireless surface electromyography system was used to measure root mean square (RMS) values of bilateral rectus femoris, semitendinosus, tibialis anterior, and lateral gastrocnemius muscles during maximal voluntary contraction and level walking. The activation ratios of the flexor and extensor muscle groups were calculated to evaluate muscle synergy patterns. The effects of Healthy-side strength training on bilateral lower limb muscle activation patterns and knee joint function were assessed through within-group pre- and post-intervention comparisons and between-group analyses. RESULTS: Following the 6-week intervention, Lysholm knee function scores improved significantly in both groups, with the intervention group demonstrating a significantly greater magnitude of improvement than the control group (P < 0.01). At baseline, the RMS values of all recorded muscles on the affected side were significantly lower than those on the unaffected side during both MVC and level walking in both groups (P < 0.01). Following the intervention, the intervention group demonstrated significant reductions in affected-to-unaffected limb asymmetry across all four muscle groups during both MVC and level walking (P < 0.01), whereas the control group exhibited significant asymmetry reductions in only a limited number of muscle groups during MVC alone (P < 0.01). In the intervention group, the RMS values of the bilateral rectus femoris, semitendinosus, tibialis anterior, and lateral gastrocnemius increased significantly during both MVC and level walking relative to baseline (P < 0.05). In contrast, the control group demonstrated significant improvements in only a limited subset of muscle groups. Between-group post-intervention comparisons revealed that the intervention group achieved significantly higher activation levels in the unaffected-side rectus femoris, bilateral semitendinosus, and unaffected-side tibialis anterior than the control group (P < 0.05). Both groups exhibited a declining trend in flexor-extensor co-contraction ratios; however, neither between-group nor within-group differences reached statistical significance (P > 0.05). CONCLUSION: Healthy-Side Lower-Limb Strength Training effectively promoted knee joint function recovery and enhanced bilateral lower limb muscle activation in patients following ACLR through cross-education mechanisms. These findings validate the clinical utility of cross-education theory and support Healthy-side strength training as an innovative rehabilitation strategy for early post-ACLR recovery. TRIAL REGISTRATION: Chinese Clinical Trial Registry ChiCTR2400087325. Registered on 25/07/2024. CI - (c) 2026. The Author(s). FAU - Liu, Chao AU - Liu C AD - Department of Sports Training, Tianjin University of Sport, Tianjin, China. FAU - Sun, ZiHao AU - Sun Z AD - Department of Special Education and Rehabilitation, Binzhou Medical University, Yantai City, Shandong Province, China. FAU - Jiang, XiangZhan AU - Jiang X AD - Department of Special Education and Rehabilitation, Binzhou Medical University, Yantai City, Shandong Province, China. FAU - Liu, BaoHua AU - Liu B AD - Department of Social Sports, Tianjin University of Sport, Tianjin, China. liubaohua8259@163.com. FAU - Zhao, YueHan AU - Zhao Y AD - Department of Rehabilitation Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China. Aa19861802747@163.com. LA - eng GR - KFKT-2023-026/Science and Technology Development Project of the Chinese Association of Rehabilitation Medicine/ GR - 23ZYJ0228/2023 Higher Education Science Research Plan Project of the China Association of Higher Education/ GR - 50012304488/Scientific Foundation of Binzhou Medical University/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20260313 PL - England TA - J Orthop Surg Res JT - Journal of orthopaedic surgery and research JID - 101265112 SB - IM MH - Humans MH - *Resistance Training/methods MH - Male MH - Female MH - *Anterior Cruciate Ligament Reconstruction/rehabilitation MH - Single-Blind Method MH - *Recovery of Function/physiology MH - Adult MH - Young Adult MH - *Lower Extremity/physiology MH - Muscle, Skeletal/physiology MH - Muscle Strength/physiology MH - Electromyography MH - Adolescent MH - Treatment Outcome MH - *Anterior Cruciate Ligament Injuries/surgery/physiopathology/rehabilitation MH - Knee Joint/physiopathology PMC - PMC13097873 OTO - NOTNLM OT - Anterior cruciate ligament reconstruction OT - Cross-education OT - Healthy-side strength training OT - Muscle activation OT - Neuroplasticity OT - Surface electromyography COIS- Declarations. Ethics approval and consent to participate: The studies involving human participants were reviewed and approved by the Ethics Committee of the Affiliated Hospital of Binzhou Medical University. The patients/participants provided their written informed consent to participate in this study. Consent for publication: Written informed consent for publication was obtained from all participants. The participant in Figs. 1, 2, 3 and 4 specifically consented to publication of this de-identified image, which does not display facial features or any personally identifiable information. Consent for publication: Participants give their consent for publication of their image if require. Competing interests: The authors declare no competing interests. EDAT- 2026/03/14 06:33 MHDA- 2026/04/22 00:34 PMCR- 2026/03/13 CRDT- 2026/03/14 00:56 PHST- 2025/12/30 00:00 [received] PHST- 2026/02/18 00:00 [accepted] PHST- 2026/04/22 00:34 [medline] PHST- 2026/03/14 06:33 [pubmed] PHST- 2026/03/14 00:56 [entrez] PHST- 2026/03/13 00:00 [pmc-release] AID - 10.1186/s13018-026-06776-6 [pii] AID - 6776 [pii] AID - 10.1186/s13018-026-06776-6 [doi] PST - epublish SO - J Orthop Surg Res. 2026 Mar 13;21(1):269. doi: 10.1186/s13018-026-06776-6. PMID- 41827029 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260813 IS - 1479-5868 (Electronic) IS - 1479-5868 (Linking) VI - 23 IP - 1 DP - 2026 Mar 13 TI - Recess and after-hours behavior patterns associated with community schoolyard transformations. LID - 10.1186/s12966-026-01899-9 [doi] LID - 25 AB - BACKGROUND: Spending time in nature and physical activity are both linked to better health outcomes for children. School environments provide the potential for multiple interventions to promote healthy behaviors. Transforming these existing public spaces to serve broader activity functions provides opportunities to support healthy child development and to increase nature access for local communities. METHODS: Our quasi-experimental design capitalized on a community-engaged schoolyard redesign and redevelopment project completed at two elementary schools in Tacoma, Washington, USA, led by the Trust for Public Land. Renovations included painting paved surfaces, installation of new play structures, adding walking paths and log seating areas, and planting trees. We used a validated momentary time sampling observational tool, the System for Observing Outdoor Play Environments in Neighborhood schools (SOOPEN), before and after for two schools undergoing the transformation and a control school. Moderate-to-vigorous physical activity (MVPA) and within-group behaviors in the schoolyard were observed. We used a difference-in-difference approach to estimate the effect of the schoolyard renovation on behavior during recess, and on community use of the schoolyard outside of school hours. RESULTS: The schoolyard transformation was associated with a 1.51-times greater increase (95% CI: 0.95, 2.40) in MVPA during recess at intervention schools compared to the control school, although this association was only statistically significant among groups of boys. After renovation, MVPA was highest in grassy areas at one school (69%), but highest in paved zones with newly painted markings at the other (75%). Renovations were not associated with changes in the prevalence of prosocial behavior during recess, which was high at baseline. The schoolyard transformation was also associated with increased community use outside of school hours, especially for groups of children (5.8-times [95% CI: 1.4, 23.8] greater increase in use over time at renovation schools compared to the control school). CONCLUSIONS: Schoolyard transformations have the potential to increase schoolyard use and physical activity both during and outside of school hours, if campuses are open to community use. Additional rigorous research can inform future projects to support the health of school-age children and address inequities in distribution of community greenspaces. FAU - Hazlehurst, Marnie F AU - Hazlehurst MF AD - Seattle Children's Research Institute, Seattle, WA, USA. FAU - Wolf, Kathleen L AU - Wolf KL AD - University of Washington, Seattle, WA, USA. FAU - Simmons, Cary AU - Simmons C AD - Trust for Public Land, Washington, DC, USA. FAU - Evans, Sarneshea AU - Evans S AD - Trust for Public Land, Washington, DC, USA. FAU - Steiner, Mary Kathleen AU - Steiner MK AD - Seattle Children's Research Institute, Seattle, WA, USA. FAU - Garrett, Kimberly A AU - Garrett KA AD - Seattle Children's Research Institute, Seattle, WA, USA. FAU - Tandon, Pooja S AU - Tandon PS AD - Seattle Children's Research Institute, Seattle, WA, USA. pooja.tandon@seattlechildrens.org. AD - Trust for Public Land, Washington, DC, USA. pooja.tandon@seattlechildrens.org. AD - Department of Pediatrics, University of Washington, Seattle, WA, USA. pooja.tandon@seattlechildrens.org. LA - eng PT - Journal Article DEP - 20260313 PL - England TA - Int J Behav Nutr Phys Act JT - The international journal of behavioral nutrition and physical activity JID - 101217089 SB - IM MH - Humans MH - *Schools MH - Child MH - Play and Playthings MH - *Exercise MH - *Environment Design MH - Washington MH - *Neighborhood Characteristics MH - *Health Behavior MH - Male MH - Residence Characteristics MH - *Child Behavior PMC - PMC13001272 OTO - NOTNLM OT - Green schoolyards OT - Physical activity OT - Schools OT - Shared use COIS- Declarations. Ethics approval and consent to participate: Both the Seattle Children's Hospital (STUDY00002677) and University of Washington (STUDY00011253) Institutional Review Boards approved this study and determined it to be exempt. Tacoma Public Schools' Data and Assessment Research Team and leadership at each school agreed to data collection on their campus by study staff. Consent for publication: Not applicable. Competing interests: C.S., S.E., and P.T. work for Trust for Public Land (TPL), an organization focused on protecting land and creating parks for people, which could be considered a competing interest given the aims of this paper. TPL also provided funding for follow-up data collection and analysis. The authors declare that they have no other competing interests. EDAT- 2026/03/14 06:31 MHDA- 2026/06/28 06:35 PMCR- 2026/03/13 CRDT- 2026/03/14 00:53 PHST- 2025/04/01 00:00 [received] PHST- 2026/02/24 00:00 [accepted] PHST- 2026/06/28 06:35 [medline] PHST- 2026/03/14 06:31 [pubmed] PHST- 2026/03/14 00:53 [entrez] PHST- 2026/03/13 00:00 [pmc-release] AID - 10.1186/s12966-026-01899-9 [pii] AID - 1899 [pii] AID - 10.1186/s12966-026-01899-9 [doi] PST - epublish SO - Int J Behav Nutr Phys Act. 2026 Mar 13;23(1):25. doi: 10.1186/s12966-026-01899-9. PMID- 41826924 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Mar 13 TI - Study protocol for a theory-informed randomized controlled trial of a lifestyle and sleep intervention to improve quality of life and physical activity in inactive adults: the SleeP exercIse nutRition heALth+ SPIRAL+ study. LID - 10.1186/s12889-026-26959-4 [doi] LID - 1297 AB - BACKGROUND: Sleep, physical activity, and diet are key determinants of health, each independently associated with chronic disease risk and mortality. These behaviors also interact: insufficient sleep can impair physical activity and dietary choices, while regular exercise and healthy diet promote better sleep. Although lifestyle interventions commonly target physical activity and diet, few simultaneously address sleep. Emerging evidence suggests that even small improvements across all three behaviors can reduce all-cause mortality, highlighting the potential of multi-behavior approaches. However, the effects of a lifestyle intervention simultaneously targeting sleep, physical activity, and diet on quality of life and physical activity levels in inactive adults remain largely unexplored. METHODS: The SPIRAL+ study is a single-center, randomized controlled trial conducted in France, among non-exercising adults aged 18-80 years. Participants (n = 201) will be randomized to one of three groups: (1) lifestyle intervention (physical activity and diet) (2), lifestyle plus sleep intervention, or (3) control. Assessments will be conducted at baseline, 6 months (post-intervention), and 12 months. The primary outcomes are health-related quality of life (EQ-5D-5 L) and daily step count (measured by accelerometer) assessed immediately after the 6-month intervention. Secondary outcomes include whether intervention effects are sustained at 12 months, along with markers of physical fitness (cardiorespiratory fitness, body composition, handgrip strength), physical activity and sedentary behavior (accelerometry), and sleep (home-based sleep test, actigraphy, and validated questionnaires). Additional self-reported outcomes will cover diet, mental wellbeing, motivation, quality of life, and psychological constructs related to health behavior change. A qualitative component will explore barriers and facilitators to adherence through semi-structured interviews. DISCUSSION: This trial will evaluate whether adding a sleep component to a lifestyle intervention improves quality of life and physical activity levels in inactive adults. If effective, the findings will support the integration of sleep into multi-behavior interventions to enhance health outcomes and inform future public health strategies. TRIAL REGISTRATION: Clinical Trials NCT06424847. FAU - Mendelson, Monique AU - Mendelson M AD - Univ. Grenoble Alps, HP2 Laboratory, Inserm U1300, Grenoble, France. monique.mendelson@univ-grenoble-alpes.fr. FAU - Coudurier, Marie AU - Coudurier M AD - Sports & Pathology Department, CHU Grenoble Alpes, Echirolles, France. FAU - Doutreleau, Stephane AU - Doutreleau S AD - Univ. Grenoble Alps, HP2 Laboratory, Inserm U1300, Grenoble, France. AD - Sports & Pathology Department, CHU Grenoble Alpes, Echirolles, France. FAU - Guinot, Michel AU - Guinot M AD - Univ. Grenoble Alps, HP2 Laboratory, Inserm U1300, Grenoble, France. AD - Sports & Pathology Department, CHU Grenoble Alpes, Echirolles, France. FAU - Flore, Patrice AU - Flore P AD - Univ. Grenoble Alps, HP2 Laboratory, Inserm U1300, Grenoble, France. FAU - Bailly, Sebastien AU - Bailly S AD - Univ. Grenoble Alps, HP2 Laboratory, Inserm U1300, Grenoble, France. FAU - Baillieul, Sebastien AU - Baillieul S AD - Univ. Grenoble Alps, HP2 Laboratory, Inserm U1300, Grenoble, France. AD - Laboratoire Du Sommeil, Pole Thorax et Vaisseaux, CHU Grenoble Alpes, Grenoble, France. FAU - Destors, Marie AU - Destors M AD - Laboratoire Du Sommeil, Pole Thorax et Vaisseaux, CHU Grenoble Alpes, Grenoble, France. FAU - Tamisier, Renaud AU - Tamisier R AD - Univ. Grenoble Alps, HP2 Laboratory, Inserm U1300, Grenoble, France. AD - Laboratoire Du Sommeil, Pole Thorax et Vaisseaux, CHU Grenoble Alpes, Grenoble, France. FAU - Pepin, Jean-Louis AU - Pepin JL AD - Univ. Grenoble Alps, HP2 Laboratory, Inserm U1300, Grenoble, France. AD - Laboratoire Du Sommeil, Pole Thorax et Vaisseaux, CHU Grenoble Alpes, Grenoble, France. FAU - Tessier, Damien AU - Tessier D AD - Univ. Grenoble-Alpes, SENS, Grenoble, France. FAU - Roustit, Matthieu AU - Roustit M AD - Univ. Grenoble Alps, HP2 Laboratory, Inserm U1300, Grenoble, France. AD - Inserm CIC 1406, Grenoble Alps University Hospital, Univ. Grenoble Alps, Grenoble, France. FAU - Manceau, Marc AU - Manceau M AD - Inserm CIC 1406, Grenoble Alps University Hospital, Univ. Grenoble Alps, Grenoble, France. FAU - Chalabaev, Aina AU - Chalabaev A AD - Univ. Grenoble-Alpes, SENS, Grenoble, France. FAU - Verges, Samuel AU - Verges S AD - Univ. Grenoble Alps, HP2 Laboratory, Inserm U1300, Grenoble, France. LA - eng SI - ClinicalTrials.gov/NCT06424847 GR - SIP/Institut pour la Recherche en Sante Publique/ GR - ANR-15-IDEX-02/Agence Nationale de la Recherche/ PT - Clinical Trial Protocol PT - Journal Article DEP - 20260313 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - *Quality of Life MH - Adult MH - Middle Aged MH - *Exercise/psychology MH - *Sleep MH - Adolescent MH - Young Adult MH - Female MH - Aged MH - Male MH - *Life Style MH - Randomized Controlled Trials as Topic MH - France MH - *Sedentary Behavior MH - Aged, 80 and over MH - Diet MH - *Health Promotion/methods PMC - PMC13097937 OTO - NOTNLM OT - lifestyle intervention OT - physical activity OT - quality of life OT - sleep COIS- Declarations. Ethics approval and consent to participate: This study was approved by the French national ethics committee (Comite de protection des personnes Sud-Est I) on March 24th 2024. Notification of the Committee's approval was forwarded to the National Medicines Safety Agency (ANSM) by the sponsor (Grenoble Alpes University Hospital, Delegation for Clinical Research and Innovation). Moreover, the study was registered on Clinical-Trials.gov (NCT06424847) on 16/05/2024. The protocol was amended on February 13th 2025 in order to reduce the number of questionnaires, and add precisions regarding inclusion criteria. The current protocol is version 2 (13/02/2025). All potential major changes to the protocol will be reported to the relevant regulatory authorities All participants that volunteer will be asked to sign a written informed consent prior to program participation with a study investigator. The sponsor and investigators commit to conducting the clinical investigation in compliance with French law (Law n degrees 2012-300, March 5, 2012), European Regulation n degrees 2017/745, ISO Standard 14155:2020, and the Declaration of Helsinki. Investigators will ensure proper consent collection and adverse event reporting. The sponsor will be in charge of auditing and monitoring. Data will be processed in compliance with French data protection laws (Law no. 78-17 of 1978, amended by law no. 2018-493) and the EU GDPR (Regulation 2016/679). This investigation complies with the Reference Methodology" (MR-001) per article 54(5) of the amended 1978 law and has authorization from the National Commission for Information Technology and Civil Liberties (CNIL). The sponsor of the study has committed to adhering to this methodology and has obtained dedicated insurance coverage. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/14 06:33 MHDA- 2026/06/28 00:37 PMCR- 2026/03/13 CRDT- 2026/03/14 00:48 PHST- 2025/10/01 00:00 [received] PHST- 2026/03/06 00:00 [accepted] PHST- 2026/06/28 00:37 [medline] PHST- 2026/03/14 06:33 [pubmed] PHST- 2026/03/14 00:48 [entrez] PHST- 2026/03/13 00:00 [pmc-release] AID - 10.1186/s12889-026-26959-4 [pii] AID - 26959 [pii] AID - 10.1186/s12889-026-26959-4 [doi] PST - epublish SO - BMC Public Health. 2026 Mar 13;26(1):1297. doi: 10.1186/s12889-026-26959-4. PMID- 41825737 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260711 IS - 1541-6100 (Electronic) IS - 0022-3166 (Linking) VI - 156 IP - 5 DP - 2026 May TI - Artificial Intelligence-Assisted Dietary Assessment in Adolescent Girls in Sri Lanka: Validity against Weighed Food Records and Comparison with 24-Hour Recalls. PG - 101476 LID - S0022-3166(26)00125-2 [pii] LID - 10.1016/j.tjnut.2026.101476 [doi] AB - BACKGROUND: Reliable dietary data for adolescents in low- and middle-income countries (LMICs) are limited due to high costs and estimation errors in traditional dietary assessment methods. Although technology-assisted dietary assessment tools are becoming popular, few have been validated in LMICs. OBJECTIVES: This study validated the PlantVillage Food Recognition Assistance and Nudging Insights (FRANI), an artificial intelligence-assisted mobile application for dietary assessment, against weighed food records (WFR) and multipass 24-h recalls (24HR) among adolescent girls aged 14‒18 y (n = 60) in urban/semi-urban communities in Sri Lanka. METHODS: Dietary intake was assessed over 2 non-consecutive days using 3 methods: FRANI, WFR, and 24HR. The equivalence of nutrient intake was evaluated using mixed-effect models accounting for repeated measures by comparing intake ratios (FRANI/WFR and 24HR/WFR) with 10%, 15%, and 20% equivalence bounds. The concordance correlation coefficient was utilized to assess the agreement between methods. RESULTS: FRANI demonstrated equivalence with WFR at the 10% bound for energy and vitamin A; 15% for protein, fiber, iron, and zinc; and 20% for fat, niacin, and folate intakes. Comparisons between 24HR and WFR found that no nutrients fell within the 10% bound. Energy, protein, fat, iron, niacin, and vitamin A intakes were equivalent at 15% bound, whereas fiber, calcium, folate, and vitamin C intakes were equivalent at 20% bound. Concordance correlation coefficient ranged from 0.49 to 0.89 for FRANI compared to WFR, and 0.44 to 0.84 for 24HR compared with WFR. Omission errors were 2% for FRANI and 12% for 24HR, and intrusion errors were 7% and 9%, respectively. CONCLUSIONS: PlantVillage FRANI application accurately estimated nutrient intakes of adolescent girls in Sri Lanka compared to the WFR. Its performance was at least comparable to the traditional 24HR method, supporting its potential as a scalable alternative for dietary assessment in similar LMIC populations. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Karunarathna, Nilmini AU - Karunarathna N AD - Department of Nutrition and Dietetics, Faculty of Livestock, Fisheries and Nutrition, Wayamba University of Sri Lanka, Makandura, Gonawila, Sri Lanka. Electronic address: karunarathnahmnj@wyb.ac.lk. FAU - Perera, Thushanthi AU - Perera T AD - Department of Nutrition and Dietetics, Faculty of Livestock, Fisheries and Nutrition, Wayamba University of Sri Lanka, Makandura, Gonawila, Sri Lanka. FAU - Nwabuikwu, Odiche AU - Nwabuikwu O AD - International Food Policy Research Institute, Washington, DC, United States. FAU - Bannerman, Boateng AU - Bannerman B AD - Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana. FAU - Bempong, Silas AU - Bempong S AD - Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana. FAU - McCloskey, Peter AU - McCloskey P AD - Plant Village, Penn State University, State College, PA, United States. FAU - Nguyen, Phuong Hong AU - Nguyen PH AD - International Food Policy Research Institute, Washington, DC, United States; Thai Nguyen University of Pharmacy and Medicine, Thai Nguyen, Vietnam. FAU - Hughes, David AU - Hughes D AD - Plant Village, Penn State University, State College, PA, United States. FAU - Folson, Gloria AU - Folson G AD - Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana. FAU - Silva, Renuka AU - Silva R AD - Department of Nutrition and Dietetics, Faculty of Livestock, Fisheries and Nutrition, Wayamba University of Sri Lanka, Makandura, Gonawila, Sri Lanka. FAU - Gelli, Aulo AU - Gelli A AD - International Food Policy Research Institute, Washington, DC, United States. LA - eng PT - Comparative Study PT - Journal Article PT - Validation Study DEP - 20260312 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 SB - IM MH - Female MH - Sri Lanka MH - Humans MH - Adolescent MH - *Nutrition Assessment MH - *Diet Records MH - *Mental Recall MH - Reproducibility of Results MH - *Diet MH - Energy Intake OTO - NOTNLM OT - AI-assisted dietary assessment OT - Sri Lanka OT - adolescents OT - dietary assessment methods OT - validation COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/03/14 00:31 MHDA- 2026/05/09 00:34 CRDT- 2026/03/13 20:16 PHST- 2025/09/22 00:00 [received] PHST- 2025/12/17 00:00 [revised] PHST- 2026/03/09 00:00 [accepted] PHST- 2026/05/09 00:34 [medline] PHST- 2026/03/14 00:31 [pubmed] PHST- 2026/03/13 20:16 [entrez] AID - S0022-3166(26)00125-2 [pii] AID - 10.1016/j.tjnut.2026.101476 [doi] PST - ppublish SO - J Nutr. 2026 May;156(5):101476. doi: 10.1016/j.tjnut.2026.101476. Epub 2026 Mar 12. PMID- 41824634 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260313 LR - 20260813 IS - 2291-9279 (Print) IS - 2291-9279 (Electronic) VI - 14 DP - 2026 Mar 13 TI - Development of a Novel Dietary Assessment Method Using Gamification Concepts: Exploratory and Application Study. PG - e72387 LID - 10.2196/72387 [doi] LID - e72387 AB - BACKGROUND: Childhood and adolescent malnutrition, encompassing undernutrition and overnutrition, poses significant global health challenges, necessitating comprehensive dietary assessment tools. Existing dietary assessment methods, such as 24-hour dietary recalls (24HR), often fail to capture eating behaviors and food preferences. OBJECTIVE: This study aims to compare a newly developed gamified dietary assessment tool (GDA) with a traditional 24HR and to explore its applicability in assessing dietary behavior tendencies among children and adolescents. METHODS: A 2-phase study was designed, including an exploratory and an application study. The exploratory study included 30 school-aged participants, comparing the GDA with the 3-day 24HR. Nutrient and food intakes were analyzed using Pearson or Spearman correlation coefficients and Bland-Altman plots. The application study, conducted among 1541 adolescents (11-18 y), assessed dietary intake and eating behavior tendencies. Differences in dietary intake across age, gender, socioeconomic status, and weight status were analyzed using the Kruskal-Wallis rank sum test. Multiple linear regression models were used to examine the associations of dietary intakes with emotional eating and with dining environment tendencies, respectively. RESULTS: In the exploratory study (n=30), the GDA demonstrated moderate agreement with 24HR for energy (r=0.46, P=.01) and carbohydrates (r=0.50, P=.005). Bland-Altman plots indicated good agreement for energy and carbohydrate intake between methods (mean differences around 0). For fat intake, although the mean difference was close to 0, the correlation was not statistically significant. In contrast, the GDA substantially overestimated protein intake (mean difference around 25 g). In the application study (n=1541), higher emotional eating scores were associated with higher snack consumption (beta=0.438, 95% CI 0.035-0.840), and with lower protein (beta=-0.159, 95% CI -0.267 to -0.052), fruit (beta=-0.464, 95% CI -0.854 to -0.073), and nut consumption (beta=-0.183, 95% CI -0.304 to -0.062). Participants who chose solitary screen eating consumed significantly more carbohydrates than those who selected "eat with peers" (beta=4.2, 95% CI 1.2-7.1). CONCLUSIONS: This study demonstrates that the GDA effectively captures both dietary intake and contextual eating behaviors in young populations, providing data distinct from traditional methods, such as 24HR. As a complementary assessment approach, it offers valuable insights into food preferences and eating patterns through its interactive design. CI - (c) Yulin Zhang, Tianwu Lin, Yuefeng Tan, Xiaojin Shi, Yucheng Yang, Haibing Yang, Xiaona Na, Junhan Zhang, Ai Zhao. Originally published in JMIR Serious Games (https://games.jmir.org). FAU - Zhang, Yulin AU - Zhang Y AUID- ORCID: 0000-0002-3259-9498 AD - Vanke School of Public Health, Tsinghua University, Jinchunyuan Building, Tsinghua University, 30th Shuang Qing Road, Hadian District, Beijing, 100084, China, 86 13811131994. FAU - Lin, Tianwu AU - Lin T AUID- ORCID: 0009-0009-7509-8536 AD - Shenzhen Yantian Maternal and Child Health Hospital, Shenzhen, Guangdong, China. FAU - Tan, Yuefeng AU - Tan Y AUID- ORCID: 0009-0003-3294-9122 AD - Vanke School of Public Health, Tsinghua University, Jinchunyuan Building, Tsinghua University, 30th Shuang Qing Road, Hadian District, Beijing, 100084, China, 86 13811131994. FAU - Shi, Xiaojin AU - Shi X AUID- ORCID: 0000-0002-1738-2856 AD - Vanke School of Public Health, Tsinghua University, Jinchunyuan Building, Tsinghua University, 30th Shuang Qing Road, Hadian District, Beijing, 100084, China, 86 13811131994. FAU - Yang, Yucheng AU - Yang Y AUID- ORCID: 0000-0003-4402-631X AD - Vanke School of Public Health, Tsinghua University, Jinchunyuan Building, Tsinghua University, 30th Shuang Qing Road, Hadian District, Beijing, 100084, China, 86 13811131994. FAU - Yang, Haibing AU - Yang H AUID- ORCID: 0009-0008-2141-505X AD - Vanke School of Public Health, Tsinghua University, Jinchunyuan Building, Tsinghua University, 30th Shuang Qing Road, Hadian District, Beijing, 100084, China, 86 13811131994. FAU - Na, Xiaona AU - Na X AUID- ORCID: 0000-0002-0107-252X AD - Vanke School of Public Health, Tsinghua University, Jinchunyuan Building, Tsinghua University, 30th Shuang Qing Road, Hadian District, Beijing, 100084, China, 86 13811131994. FAU - Zhang, Junhan AU - Zhang J AUID- ORCID: 0000-0001-5293-1198 AD - Vanke School of Public Health, Tsinghua University, Jinchunyuan Building, Tsinghua University, 30th Shuang Qing Road, Hadian District, Beijing, 100084, China, 86 13811131994. FAU - Zhao, Ai AU - Zhao A AUID- ORCID: 0000-0002-1679-973X AD - Vanke School of Public Health, Tsinghua University, Jinchunyuan Building, Tsinghua University, 30th Shuang Qing Road, Hadian District, Beijing, 100084, China, 86 13811131994. LA - eng PT - Journal Article DEP - 20260313 PL - Canada TA - JMIR Serious Games JT - JMIR serious games JID - 101645255 PMC - PMC12987409 OTO - NOTNLM OT - dietary assessment OT - dietary intake OT - eating behavior tendencies OT - food preference OT - gamification COIS- Conflicts of Interest: None declared. EDAT- 2026/03/13 19:31 MHDA- 2026/03/13 19:32 PMCR- 2026/03/13 CRDT- 2026/03/13 14:23 PHST- 2025/02/26 00:00 [received] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/03/13 19:32 [medline] PHST- 2026/03/13 19:31 [pubmed] PHST- 2026/03/13 14:23 [entrez] PHST- 2026/03/13 00:00 [pmc-release] AID - v14i1e72387 [pii] AID - 72387 [pii] AID - 10.2196/72387 [doi] PST - epublish SO - JMIR Serious Games. 2026 Mar 13;14:e72387. doi: 10.2196/72387. PMID- 41823958 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260831 IS - 2689-0186 (Electronic) IS - 2689-0186 (Linking) VI - 7 IP - 3 DP - 2026 Mar 6 TI - Instability of Global Burden of Disease Estimates of Deaths and Disability-Adjusted Life-Years From Major Risk Factors: A Meta-Epidemiological Analysis. PG - e260108 LID - 10.1001/jamahealthforum.2026.0108 [doi] LID - e260108 AB - IMPORTANCE: The Global Burden of Disease (GBD) reports widely used estimates of mortality and disability-adjusted life-years (DALYs) and related risk factors. However, the overall reliability of these estimates between GBD iterations has not been assessed. OBJECTIVE: To evaluate the instability and inconsistency of GBD risk factor estimates for mortality and DALYs across GBD iterations. DATA SOURCES: GBD risk factor collaboration estimates extracted from the published tables of GBD iterations and the Institute for Health Metrics and Evaluation repository. STUDY SELECTION: GBD risk factor collaboration publications published for 2010 through 2023. DATA EXTRACTION AND SYNTHESIS: Death and DALY estimates were manually extracted by 1 reviewer with independent validation of a random sample of 100 by another with no discrepancies. Risk factor naming was harmonized across iterations to ensure comparability; those with inconsistent definitions were excluded. MAIN OUTCOMES AND MEASURES: Fluctuations were calculated for numbers of deaths and DALYs for each risk factor across GBD iterations during the study period (2010-2023) and between the original and subsequently revised estimates for each year (1990-2021). Differences were expressed as a ratio of the minimum to maximum range to the mean (R:M) and coefficient of variation. Detail analyses assessed diet and low physical activity. Point estimates were compared to the previous iterations' estimates 95% uncertainty intervals (95% UI) for GBD 2019, 2021, and 2023. RESULTS: Across GBD iterations from 2010 to 2023, the median (range) R:M was 0.8 (0-3.8) for deaths, and 0.7 (0.1-3.3) for DALYs. Level 2 dietary and child and maternal malnutrition death estimates showed high instability (R:M >1 for 9 of 16 and 4 of 8 risks, respectively). When comparing original estimates with GBD 2019, 2021, and 2023 estimates for the same years, the median R:M was 0.4 (0-2.9) for both deaths and DALYs. The coefficient of variation was greater than 0.2 for 336 of 675 death estimates (50%). Specifically, 70% to 96% of point estimates for red meat, sugar-sweetened beverages, fruits, vegetables, and seafood omega-3 fatty acids in GBD 2021 fell outside the GBD 2019 95% UI. In GBD 2023, only diet high in trans fats had more than half of point estimates outside the GBD 2021 95% UI. CONCLUSIONS AND RELEVANCE: This meta-epidemiological assessment indicates that GBD estimates are substantially unstable, particularly for behavioral risks, making them unlikely to simply reflect genuine changes over time, and warranting caution in interpretation. FAU - Zavalis, Emmanuel A AU - Zavalis EA AD - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. AD - Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. AD - Meta-Research Innovation Center at Stanford, Stanford University, Stanford, California. FAU - Pezzullo, Angelo Maria AU - Pezzullo AM AD - Meta-Research Innovation Center at Stanford, Stanford University, Stanford, California. AD - Section of Hygiene, Department of Life Sciences and Public Health, Universita Cattolica del Sacro Cuore, Rome, Italy. FAU - Ioannidis, John P A AU - Ioannidis JPA AD - Meta-Research Innovation Center at Stanford, Stanford University, Stanford, California. AD - Department of Medicine, Stanford University, Stanford, California. AD - Department of Epidemiology and Population Health, Stanford University, Stanford, California. AD - Department of Biomedical Data Science, Stanford University, Stanford, California. LA - eng PT - Journal Article PT - Meta-Analysis DEP - 20260306 PL - United States TA - JAMA Health Forum JT - JAMA health forum JID - 101769500 SB - IM MH - Humans MH - *Global Burden of Disease/trends MH - Risk Factors MH - *Disability-Adjusted Life Years MH - *Mortality/trends PMC - PMC12988449 COIS- Conflict of Interest Disclosures: Dr Pezzullo reported membership in the Global Burden of Disease Collaborator Network (nonfinancial relationship). No other disclosures were reported. EDAT- 2026/03/13 12:41 MHDA- 2026/03/13 12:42 PMCR- 2026/03/13 CRDT- 2026/03/13 11:33 PHST- 2026/03/13 12:42 [medline] PHST- 2026/03/13 12:41 [pubmed] PHST- 2026/03/13 11:33 [entrez] PHST- 2026/03/13 00:00 [pmc-release] AID - 2845973 [pii] AID - aoi260003 [pii] AID - 10.1001/jamahealthforum.2026.0108 [doi] PST - epublish SO - JAMA Health Forum. 2026 Mar 6;7(3):e260108. doi: 10.1001/jamahealthforum.2026.0108. PMID- 41823935 OWN - NLM STAT- MEDLINE DCOM- 20260610 LR - 20260610 IS - 1878-2620 (Electronic) IS - 1499-4046 (Linking) VI - 58 IP - 6 DP - 2026 Jun TI - Valid and Reliable Questionnaire for Assessing Nutrition and Physical Activity Practices in Early Care and Education. PG - 556-565 LID - S1499-4046(26)00035-7 [pii] LID - 10.1016/j.jneb.2026.01.020 [doi] AB - OBJECTIVE: Valid, reliable, and comprehensive instruments enable early care and education (ECE) sites to self-assess nutrition and physical activity practices and policies, but availability is limited. Therefore, we developed and assessed the test-retest reliability and convergent validity of the Site-Level Assessment Questionnaire (SLAQ). DESIGN: Reliability testing compared questionnaires completed by ECE personnel at 2 time points (reliability pairs). Convergent validity testing compared questionnaires completed by ECE personnel with questionnaires completed by researchers (validity pairs). Semistructured interviews with personnel who completed the SLAQ informed revisions. SETTING: California Supplemental Nutrition Assistance Program Education-eligible ECE sites. PARTICIPANTS: Convenience sample of 32 ECE sites (18 school districts; 14 Head Starts). VARIABLES MEASURED: Seventy-six items assessing wellness policies, federal food program participation, meals, snacks, beverages, food environment, feeding practices, nutrition education, gardens, physical activity, screen time, family involvement, and breastfeeding support. ANALYSIS: Weighted kappa test statistics and percent agreement were calculated for each item to assess agreement between reliability pairs and validity pairs. RESULTS: Eighty-eight percent of items showed moderate or higher reliability; 52% had moderate or higher validity. On the basis of these results and interview findings, the SLAQ was revised to address issues identified. CONCLUSIONS AND IMPLICATIONS: Findings suggest acceptable validity and reliability of the SLAQ for assessing policies and practices at SNAP-Ed-eligible ECE sites in California. Further testing with larger, randomly selected, and geographically and socioeconomically diverse populations could broaden its application. As is, the comprehensive assessment data the SLAQ provides can be used to identify opportunities for improving ECE practices and policies that support children's health. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Becker, Christina M AU - Becker CM AD - Nutrition Policy Institute, University of California, Division of Agriculture and Natural Resources, Oakland, CA. FAU - Kao, Janice AU - Kao J AD - Nutrition Policy Institute, University of California, Division of Agriculture and Natural Resources, Oakland, CA. Electronic address: jankao@ucanr.edu. FAU - Hewawitharana, Sridharshi C AU - Hewawitharana SC AD - Nutrition Policy Institute, University of California, Division of Agriculture and Natural Resources, Oakland, CA. FAU - Rider, Carolyn D AU - Rider CD AD - Nutrition Policy Institute, University of California, Division of Agriculture and Natural Resources, Oakland, CA. FAU - Linares, Amanda AU - Linares A AD - Nutrition Policy Institute, University of California, Division of Agriculture and Natural Resources, Oakland, CA. FAU - Strochlic, Ron AU - Strochlic R AD - Nutrition Policy Institute, University of California, Division of Agriculture and Natural Resources, Oakland, CA. FAU - Brown, Miranda Westfall AU - Brown MW AD - Nutrition Policy Institute, University of California, Division of Agriculture and Natural Resources, Oakland, CA. FAU - Woodward-Lopez, Gail AU - Woodward-Lopez G AD - Nutrition Policy Institute, University of California, Division of Agriculture and Natural Resources, Oakland, CA. LA - eng PT - Journal Article PT - Validation Study DEP - 20260313 PL - United States TA - J Nutr Educ Behav JT - Journal of nutrition education and behavior JID - 101132622 SB - IM MH - Humans MH - Surveys and Questionnaires/standards MH - *Exercise MH - California MH - Reproducibility of Results MH - Child, Preschool MH - Food Assistance MH - Female OTO - NOTNLM OT - SNAP-Ed OT - early care and education OT - health promotion OT - needs assessment OT - surveys and questionnaires COIS- CONFLICT OF INTEREST DISCLOSURE The authors have not stated any conflicts of interest. EDAT- 2026/03/13 12:40 MHDA- 2026/06/11 05:41 CRDT- 2026/03/13 11:28 PHST- 2024/03/27 00:00 [received] PHST- 2026/01/12 00:00 [revised] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/06/11 05:41 [medline] PHST- 2026/03/13 12:40 [pubmed] PHST- 2026/03/13 11:28 [entrez] AID - S1499-4046(26)00035-7 [pii] AID - 10.1016/j.jneb.2026.01.020 [doi] PST - ppublish SO - J Nutr Educ Behav. 2026 Jun;58(6):556-565. doi: 10.1016/j.jneb.2026.01.020. Epub 2026 Mar 13. PMID- 41823339 OWN - NLM STAT- MEDLINE DCOM- 20261022 LR - 20261023 IS - 1934-1563 (Electronic) IS - 1934-1482 (Print) IS - 1934-1482 (Linking) VI - 18 IP - 10 DP - 2026 Oct TI - Core stability in women with and without chronic pelvic pain. PG - 1184-1193 LID - 10.1002/pmrj.70103 [doi] AB - BACKGROUND: Physical activity (PA) and core stability levels are unknown for women with musculoskeletal chronic pelvic pain (CPP) compared to healthy women. At this time, there is no validated treatment method aimed specifically at CPP. OBJECTIVE: To elucidate the PA habits and core stability of women with and without CPP. We hypothesized that aerobic and resistance PA (aPA, rPA) and core stability would differ significantly. DESIGN: Prospective, cross-sectional study. Wilcoxon rank sum tests, simple and multiple linear regressions, and Pearson chi-square test were used for analysis. SETTING: Primary and specialty care outpatient physical medicine and rehabilitation, female pelvic medicine and reconstructive surgery, and gynecology clinics associated with a large tertiary center. PATIENTS: We recruited 91 women aged 18-70 years with and without CPP (defined by American College of Obstetricians and Gynecologists). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Physical activity, core stability scores. RESULTS: Women with CPP demonstrated lower overall core stability (p = .04). Having CPP predicted a 2-point decrease in overall core score (p < .01). Women with CPP demonstrated significantly worse scores for the supine bridge (p < .01) and prone bridge (p = .03). There were no significant differences in aPA or rPA between women with and without CPP. Pelvic floor muscle strength did not have a significant effect on core scores in women with CPP before or after adjusting for age, parity, and body mass index. CONCLUSIONS: This study reports a novel finding that women with CPP had significantly reduced core scores (suggestive of weaker core stability) but similar levels of physical activity (aPA and rPA) compared to women without CPP. Future directions will include larger, multicenter, randomized controlled trials to investigate the association between pelvic floor muscles and core stability as well as therapeutic interventions to include specific exercises targeted at improving overall core stability in women with CPP. CI - (c) 2026 The Author(s). PM&R published by Wiley Periodicals LLC on behalf of American Academy of Physical Medicine and Rehabilitation. FAU - Chatwin, Hannah V AU - Chatwin HV AUID- ORCID: 0000-0001-8328-0869 AD - Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA. FAU - Kumar, Abhilasha AU - Kumar A AD - Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA. FAU - Wesolowski, Michael AU - Wesolowski M AD - Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA. FAU - Glaser, Laura AU - Glaser L AD - Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA. FAU - Fitzgerald, Colleen M AU - Fitzgerald CM AD - Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA. FAU - Bennis, Stacey AU - Bennis S AD - Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA. LA - eng PT - Journal Article DEP - 20260313 PL - United States TA - PM R JT - PM & R : the journal of injury, function, and rehabilitation JID - 101491319 SB - IM MH - Humans MH - Female MH - Adult MH - Middle Aged MH - Cross-Sectional Studies MH - *Pelvic Pain/physiopathology/rehabilitation MH - Prospective Studies MH - *Chronic Pain/physiopathology/rehabilitation MH - Aged MH - Young Adult MH - Adolescent MH - Pelvic Floor/physiopathology MH - Pain Measurement MH - *Exercise/physiology MH - Muscle Strength/physiology PMC - PMC13686104 COIS- None of the authors have a conflict of interest to disclose. EDAT- 2026/03/13 12:41 MHDA- 2026/10/22 23:28 PMCR- 2026/10/21 CRDT- 2026/03/13 08:33 PHST- 2025/12/15 00:00 [revised] PHST- 2024/12/16 00:00 [received] PHST- 2026/01/08 00:00 [accepted] PHST- 2026/10/22 23:28 [medline] PHST- 2026/03/13 12:41 [pubmed] PHST- 2026/03/13 08:33 [entrez] PHST- 2026/10/21 00:00 [pmc-release] AID - PMRJ70103 [pii] AID - 10.1002/pmrj.70103 [doi] PST - ppublish SO - PM R. 2026 Oct;18(10):1184-1193. doi: 10.1002/pmrj.70103. Epub 2026 Mar 13. PMID- 41823249 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261010 IS - 1545-1569 (Electronic) IS - 1055-6656 (Print) IS - 1055-6656 (Linking) VI - 63 IP - 11 DP - 2026 Nov TI - What We Learnt in Unilateral Cleft Lip Repair Between Millard's and Tennison-Randall's Techniques: Comparison of the Outcomes in Adult Patients. PG - 3699-3706 LID - 10.1177/10556656261422855 [doi] AB - ObjectiveTo compare long-term esthetic and morphological outcomes of unilateral cleft lip (UCL) repair using the Millard rotation-advancement versus the Tennison-Randall triangular flap technique, testing whether Millard provides superior lip symmetry.DesignRetrospective cohort study.SettingSingle tertiary cleft center.Patients, ParticipantsForty adults aged 18-25 were selected from 168 patients treated between 1988 and 1995. Inclusion criteria: complete UCL, primary cheiloplasty, absence of secondary lip revisions, complete frontal photographic documentation, and no syndromic diagnoses. Twenty underwent Millard repair and twenty Tennison-Randall repair.InterventionsPrimary UCL reconstruction performed using either Millard rotation-advancement or Tennison-Randall triangular flap. All operations were carried out by the same senior cleft surgeon under comparable operative conditions.Main Outcome Measure(s)Long-term lip symmetry quantified through a Symmetry Index derived from predefined anthropometric landmarks on standardized images. Subjective esthetic satisfaction assessed using the esthetic Units Satisfaction Questionnaire and the Cleft esthetic Rating Scale, completed by patients, the operating surgeon, and a blinded observer.ResultsMillard repair showed significantly greater medial lip width symmetry (p = .014). No significant differences were found for vermilion height, prolabial height, lateral lip width, or lip area. Subjective assessments consistently favored Millard, showing higher satisfaction and fewer negative ratings. Inter-rater reliability across evaluators was high (ICC = 0.82).ConclusionsBoth techniques produced stable long-term outcomes, but Millard yielded superior medial lip symmetry and higher esthetic satisfaction. These findings support its continued clinical preference and highlight the importance of long-term evaluations. Larger prospective studies are needed to confirm these results. FAU - Pistoia, Angelica AU - Pistoia A AUID- ORCID: 0009-0004-8009-0209 AD - Plastic and Maxillofacial Surgery Unit, Cleft and Craniofacial Center, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. RINGGOLD: 9342 AD - Plastic Surgery Unit, School of Medicine and Surgery, Tor Vergata University of Rome, Rome, Italy. FAU - Rizzo, Maria Ida AU - Rizzo MI AD - Plastic and Maxillofacial Surgery Unit, Cleft and Craniofacial Center, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. RINGGOLD: 9342 FAU - Grippaudo, Francesca R AU - Grippaudo FR AD - Plastic Surgery Unit, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy. RINGGOLD: 60218 FAU - Cajozzo, Marta AU - Cajozzo M AD - Plastic and Maxillofacial Surgery Unit, Cleft and Craniofacial Center, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. RINGGOLD: 9342 FAU - Grussu, Francesca AU - Grussu F AD - Plastic and Maxillofacial Surgery Unit, Cleft and Craniofacial Center, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. RINGGOLD: 9342 FAU - Molinaro, Francesco AU - Molinaro F AD - Division of Pediatric Surgery, Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy. RINGGOLD: 9313 FAU - Nascimben, Francesca AU - Nascimben F AD - Plastic and Maxillofacial Surgery Unit, Cleft and Craniofacial Center, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. RINGGOLD: 9342 AD - Division of Pediatric Surgery, Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy. RINGGOLD: 9313 FAU - Zama, Mario AU - Zama M AD - Plastic and Maxillofacial Surgery Unit, Cleft and Craniofacial Center, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. RINGGOLD: 9342 LA - eng PT - Comparative Study PT - Journal Article DEP - 20260313 PL - United States TA - Cleft Palate Craniofac J JT - The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association JID - 9102566 SB - IM MH - Humans MH - *Cleft Lip/surgery MH - Adult MH - *Surgical Flaps MH - *Plastic Surgery Procedures/methods MH - Treatment Outcome MH - Patient Satisfaction MH - Female MH - Male MH - Adolescent MH - Esthetics MH - Young Adult MH - Cohort Studies MH - Surveys and Questionnaires PMC - PMC13646428 OTO - NOTNLM OT - Millard technique OT - Tennison-Randall technique OT - cheiloplasty OT - unilateral cleft lip COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/03/13 12:40 MHDA- 2026/10/07 17:33 PMCR- 2026/10/08 CRDT- 2026/03/13 07:44 PHST- 2026/10/07 17:33 [medline] PHST- 2026/03/13 12:40 [pubmed] PHST- 2026/03/13 07:44 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - 10.1177_10556656261422855 [pii] AID - 10.1177/10556656261422855 [doi] PST - ppublish SO - Cleft Palate Craniofac J. 2026 Nov;63(11):3699-3706. doi: 10.1177/10556656261422855. Epub 2026 Mar 13. PMID- 41821066 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260813 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Mar 12 TI - Association between family sports environment and adolescent physical activity: the mediating role of basic psychological needs and the moderating role of academic stress. LID - 10.1186/s40359-026-04299-7 [doi] LID - 569 AB - PURPOSE: Rooted in the integration of Self-Determination Theory (SDT) and Conservation of Resources Theory (COR), this study aims to explore the associations linking family sports environment to adolescent Moderate-to-Vigorous Physical Activity (MVPA). Specifically, it examines the mediating role of basic psychological needs satisfaction and the conditional indirect effects of academic stress on this mediated pathway. METHODS: A multi-stage hybrid sampling method was employed to recruit 523 adolescents (Mean Age = 15.23, SD = 1.76) from six secondary schools across Eastern, Central, and Western China. Participants completed the Family Sports Environment Scale, the Basic Psychological Needs in Exercise Scale, and the Adolescent Academic Stress Scale. Physical activity was objectively measured using ActiGraph GT3X+ accelerometers (valid wear time >/= 4 days, including 1 weekend day). Parental education level and BMI were included as covariates. Data were analyzed using SPSS 26.0 and the PROCESS macro (Model 59). RESULTS: (1) Measurement model assessment confirmed satisfactory reliability and validity for all constructs. (2) Family sports environment was significantly and positively associated with adolescent MVPA (beta= 0.15,[Formula: see text]), with basic psychological needs serving as a significant mediating pathway. (3) Academic stress was observed as a "dual-stage" moderator: it negatively moderated the first stage of the theoretically linked pathway (family environment [Formula: see text] needs satisfaction), consistent with the resource depletion hypothesis; conversely, it positively moderated the second stage (needs satisfaction [Formula: see text] MVPA), consistent with the compensatory coping hypothesis. Crucially, despite these opposing moderating effects, the overall indirect effect of family environment on MVPA remained robust and stable across low, medium, and high levels of academic stress. CONCLUSION: The findings suggest a complex homeostatic dynamic where the opposing moderating effects of academic stress counterbalance each other. While high stress may attenuate the perception of family support, it simultaneously amplifies the motivation to engage in physical activity when psychological needs are satisfied. These results highlight the potential resilience of family support as a resource for adolescent health behaviors. FAU - Li, Wenqiong AU - Li W AD - School of Physical Education, Shandong University of Aeronautics and Astronautics, Shandong, China. FAU - Jia, Hui AU - Jia H AUID- ORCID: 0009-0009-3035-5981 AD - ZhengZhou University, Zhengzhou, China. FAU - Han, Chongyang AU - Han C AD - Tianjin Medical University, Tianjin, China. FAU - Ma, Dongdong AU - Ma D AD - Tianjin Medical University, Tianjin, China. madongdon@126.com. LA - eng PT - Journal Article DEP - 20260312 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Adolescent MH - *Sports/psychology MH - *Exercise/psychology MH - *Stress, Psychological/psychology MH - Female MH - Male MH - China MH - *Family/psychology MH - Academia MH - Personal Satisfaction MH - *Adolescent Behavior/psychology PMC - PMC13097537 OTO - NOTNLM OT - Academic Stress OT - Accelerometry OT - Basic Psychological Needs OT - Family Sports Environment OT - Moderate-to-Vigorous Physical Activity (MVPA) OT - Self-Determination Theory COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki. The research protocol was approved by the Ethics Committee of Tianjin Medical University (Approval No. TMU-REC-2024-068). Informed written consent was obtained from all legal guardians of the adolescent participants, and verbal assent was provided by the adolescent participants themselves. All study procedures were performed with the full understanding and cooperation of the participants. Competing interests: The authors declare no competing interests. EDAT- 2026/03/13 06:52 MHDA- 2026/06/28 13:04 PMCR- 2026/03/12 CRDT- 2026/03/13 01:09 PHST- 2026/01/25 00:00 [received] PHST- 2026/03/02 00:00 [accepted] PHST- 2026/06/28 13:04 [medline] PHST- 2026/03/13 06:52 [pubmed] PHST- 2026/03/13 01:09 [entrez] PHST- 2026/03/12 00:00 [pmc-release] AID - 10.1186/s40359-026-04299-7 [pii] AID - 4299 [pii] AID - 10.1186/s40359-026-04299-7 [doi] PST - epublish SO - BMC Psychol. 2026 Mar 12;14(1):569. doi: 10.1186/s40359-026-04299-7. PMID- 41820476 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Mar 12 TI - Sleep awake detection from leg-worn wearables using deep sensor fusion. LID - 10.1038/s41598-026-42310-8 [doi] LID - 9930 AB - Restful sleep is essential for health, yet many children with Attention Deficit Hyperactivity Disorder (ADHD) experience disturbances such as delayed sleep onset, shorter total sleep time, frequent awakenings, and daytime fatigue. Accurate detection of these issues is important for clinical care, but existing tools have limitations: polysomnography is costly and complex, while wrist devices often miss subtle movement or physiological changes. This study introduces a deep learning approach using data from RestEaze, a leg-worn multimodal wearable that records photoplethysmography (PPG), motion from accelerometer and gyroscope, and temperature signals. Overnight recordings were collected from 14 children referred for ADHD evaluation. A Support Vector Machine (SVM) using handcrafted features was implemented to establish a traditional baseline. Two convolutional neural network (CNN-BiLSTM) models were then developed, employing early and late-fusion of raw multimodal inputs to classify sleep and wake states in short windows. The late-fusion model achieved an area under the ROC curve of 90.94% in five-fold cross-validation. Derived metrics included total sleep time, wake after sleep onset, sleep onset latency, and awakenings. A temporal label-smoothing method further improved consistency. These findings demonstrate the feasibility of leg-based multimodal sensing and deep learning for noninvasive sleep monitoring in pediatric neurodevelopmental populations. CI - (c) 2026. The Author(s). FAU - Anwar, Yumna AU - Anwar Y AD - Department of Computer Science and Electrical Engineering, University of Maryland Baltimore County, Baltimore, MD, USA. FAU - Bansal, Kanika AU - Bansal K AD - Department of Computer Science and Electrical Engineering, University of Maryland Baltimore County, Baltimore, MD, USA. AD - Humans in Complex Systems Division, US Army DEVCOM Army Research Laboratory, Aberdeen, MD, USA. FAU - Kucukosmanoglu, Murat AU - Kucukosmanoglu M AD - D-Prime LLC, McLean, VA, 22101, USA. murat.kucukosmanoglu@dprime.ai. FAU - Dang, Quang AU - Dang Q AD - Department of Computer Science and Electrical Engineering, University of Maryland Baltimore County, Baltimore, MD, USA. FAU - Feltch, Cody AU - Feltch C AD - Tanzen Medical Inc., Severna Park, MD, 21146, USA. FAU - Brooks, Justin AU - Brooks J AD - Department of Computer Science and Electrical Engineering, University of Maryland Baltimore County, Baltimore, MD, USA. AD - D-Prime LLC, McLean, VA, 22101, USA. AD - Tanzen Medical Inc., Severna Park, MD, 21146, USA. FAU - Banerjee, Nilanjan AU - Banerjee N AD - Department of Computer Science and Electrical Engineering, University of Maryland Baltimore County, Baltimore, MD, USA. AD - Tanzen Medical Inc., Severna Park, MD, 21146, USA. LA - eng GR - 1R43MH133495-01A1/NH/NIH HHS/United States PT - Journal Article DEP - 20260312 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Wearable Electronic Devices MH - *Wakefulness/physiology MH - *Sleep/physiology MH - Child MH - Female MH - Male MH - Polysomnography/methods/instrumentation MH - Deep Learning MH - Photoplethysmography MH - Leg/physiology MH - *Attention Deficit Disorder with Hyperactivity/physiopathology/diagnosis MH - Support Vector Machine MH - Convolutional Neural Networks MH - Accelerometry MH - Sleep Duration PMC - PMC13018206 OTO - NOTNLM OT - ADHD OT - CNN-BiLSTM OT - Deep learning OT - RestEaze OT - Sleep classification OT - Wearable sensors COIS- Declarations. Competing interests: JB, CF, and NB are shareholders of Tanzen Medical Inc., the company that developed the RestEazeTM device evaluated in this study. All other authors declare that they have no competing interests. EDAT- 2026/03/13 06:52 MHDA- 2026/03/26 07:09 PMCR- 2026/03/12 CRDT- 2026/03/13 00:29 PHST- 2025/06/24 00:00 [received] PHST- 2026/02/25 00:00 [accepted] PHST- 2026/03/26 07:09 [medline] PHST- 2026/03/13 06:52 [pubmed] PHST- 2026/03/13 00:29 [entrez] PHST- 2026/03/12 00:00 [pmc-release] AID - 10.1038/s41598-026-42310-8 [pii] AID - 42310 [pii] AID - 10.1038/s41598-026-42310-8 [doi] PST - epublish SO - Sci Rep. 2026 Mar 12;16(1):9930. doi: 10.1038/s41598-026-42310-8. PMID- 41819267 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260718 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 222 DP - 2026 Jul 1 TI - The Food Motivation Battery [FMB]: preliminary validation of an acute, item-specific measure of food motivation in young adults. PG - 108535 LID - S0195-6663(26)00097-8 [pii] LID - 10.1016/j.appet.2026.108535 [doi] AB - Food motivation, defined as the amount of effort an individual is willing to exert to obtain food, influences energy intake and body weight. However, standard measures typically assess limited forms of effort within laboratory paradigms and do not capture variation across food types, restricting their ecological validity. We developed and preliminarily validated the Food Motivation Battery [FMB], a novel questionnaire assessing multiple dimensions of food-specific motivation. A college sample (n = 758) completed the FMB after selecting one high-energy-density (ED) sweet (e.g., cookie, brownie, or ice cream) and one low-ED fruit (e.g., watermelon, strawberries, apple, or banana). Participants answered food-specific motivation questions, including willingness to do finger taps (low effort), jumping jacks (high effort), and to pay for 20-min hypothetical food delivery, alongside established appetite measures (liking, wanting, prospective consumption). Eating behavior traits, subjective current appetite, arousal state, and past 7-day intake were assessed for construct validity. We evaluated differences in mean FMB scores by sex and BMI, examined associations with related constructs, and assessed intercorrelations among FMB items. Males scored higher on willingness to do jumping jacks for fruits than females. BMI was positively associated with motivation for sweets. Participants with overweight or obesity reported higher willingness to pay for sweets compared to those with lower weight. FMB scores were positively associated with food approach traits, hunger, desire to eat, boredom, and recent intake of sweets and fruits, and negatively associated with food avoidance traits and fullness. Novel motivation items were moderately correlated with established appetite items, suggesting they capture related but unique constructs. Findings support the FMB as a brief, multidimensional tool that complements existing appetite assessments and may enhance evaluation of food-specific motivation in clinical and population-based settings. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Hua, Shuxian AU - Hua S AD - Division of Child & Adolescent Psychiatry, Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, United States. Electronic address: shhua@unc.edu. FAU - Wu, Tingjia AU - Wu T AD - Division of Child & Adolescent Psychiatry, Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, United States. FAU - Atanda-Ogunleye, Olufisayo AU - Atanda-Ogunleye O AD - Division of Child & Adolescent Psychiatry, Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, United States. FAU - Ibrahim, Abdulmumin AU - Ibrahim A AD - Division of Child & Adolescent Psychiatry, Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, United States. FAU - Jansen, Elena AU - Jansen E AD - Division of Child & Adolescent Psychiatry, Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, United States. FAU - Smith, Kimberly R AU - Smith KR AD - Division of Psychiatric Neuroimaging and Division of Behavioral Neuroscience, Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, United States. FAU - Fan, Wenxuan AU - Fan W AD - Division of Child & Adolescent Psychiatry, Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, United States. FAU - Chen, Liuyi AU - Chen L AD - Division of Child & Adolescent Psychiatry, Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, United States. FAU - Carnell, Susan AU - Carnell S AD - Division of Child & Adolescent Psychiatry, Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, United States. LA - eng PT - Journal Article PT - Validation Study DEP - 20260310 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - *Motivation MH - Female MH - Male MH - Appetite MH - Surveys and Questionnaires/standards MH - Young Adult MH - *Feeding Behavior/psychology MH - Energy Intake MH - Body Mass Index MH - *Food Preferences/psychology MH - Reproducibility of Results MH - Adolescent MH - Adult MH - Eating/psychology MH - Fruit OTO - NOTNLM OT - Appetite OT - Body mass index (BMI) OT - Dietary intake OT - Eating behavior OT - Food reward OT - Ultra-processed food OT - Young adults COIS- Declaration of competing interest S.C. declares previous research funding from Eli Lilly for a project unrelated to the current work. The remaining authors declare no known competing financial interests or personal relationships that could have influenced the work reported in this paper. EDAT- 2026/03/13 00:50 MHDA- 2026/05/08 00:32 CRDT- 2026/03/12 20:12 PHST- 2025/10/02 00:00 [received] PHST- 2026/03/09 00:00 [revised] PHST- 2026/03/10 00:00 [accepted] PHST- 2026/05/08 00:32 [medline] PHST- 2026/03/13 00:50 [pubmed] PHST- 2026/03/12 20:12 [entrez] AID - S0195-6663(26)00097-8 [pii] AID - 10.1016/j.appet.2026.108535 [doi] PST - ppublish SO - Appetite. 2026 Jul 1;222:108535. doi: 10.1016/j.appet.2026.108535. Epub 2026 Mar 10. PMID- 41818750 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 Mar 12 TI - Clinical and Behavioral Outcomes During 4 Weeks of Home-Based Self-Administered Transcranial Direct Current Stimulation in Perinatal Women With Depressive Symptoms: Open-Label Exploratory Pilot Study. PG - e56454 LID - 10.2196/56454 [doi] LID - e56454 AB - BACKGROUND: Depression during the perinatal period poses significant risks to both maternal and infant health. Although transcranial direct current stimulation (tDCS) has shown promise as a safe and well-tolerated intervention for perinatal depression, empirical evidence remains limited, and no prior study has integrated clinical outcomes with continuous objective behavioral monitoring. OBJECTIVE: This pilot study aimed to evaluate the feasibility and preliminary effects of home-based tDCS combined with wearable monitoring in women with perinatal depression and to explore the correlation between behavioral and clinical measures. METHODS: In total, 38 perinatal women completed a 4-week self-administered tDCS protocol targeting the left dorsolateral prefrontal cortex (DLPFC) with 30-minute daily sessions. Participants continuously wore a wrist device (Fitbit Inspire 2) that passively collected data on the step count, distance traveled, calorie expenditure, and heart rate. Depressive symptoms were assessed at baseline (week 0), midintervention (week 2), and postintervention (week 4) using the Montgomery-Asberg Depression Rating Scale (MADRS) and the Beck Depression Inventory (BDI). Linear mixed models (LMMs) and nonparametric tests were used to evaluate changes over time, and correlations between behavioral and clinical variables were analyzed. RESULTS: Significant reductions were observed in depressive symptoms from baseline to postintervention. Mean MADRS scores decreased from 21.3 (SD 5.2) at baseline to 12.3 (SD 8.5) at week 4 (P<.001), and mean BDI scores decreased from 24.8 (SD 11.4) at baseline to 16.1 (SD 11.2) at week 4 (P<.001). Physical activity markers increased significantly: from baseline to week 4, the mean daily step count increased from 2366.8 (SD 2293.0) to 6278.7 (SD 5026.8) steps (P<.001), the mean distance traveled daily increased from 1564.6 (SD 1528.4) to 4105.9 (SD 3117.6) m (P<.001), and the mean daily calorie expenditure increased from 1130.6 (SD 759.9) to 1834.9 (SD 458.1) kcal (P<.001). However, the mean resting heart rate decreased from 85.9 (SD 9.0) to 80.4 (SD 7.0) bpm (P<.01). Exploratory correlation analyses revealed that BDI score reductions, but not MADRS changes, correlated significantly with increases in physical activity indicators (step count: r=0.401, P=.02 at week 2; r=0.351, P=.04 at week 4). CONCLUSIONS: Results showed that 4 weeks of home-based, self-administered tDCS are feasible, well tolerated, and associated with improvements in depressive symptoms and objective behavioral activity among perinatal women. Self-reported symptom changes show stronger correlations with behavioral outcomes compared to clinician-rated scores. Although the lack of a control group precludes causal inference, these findings support the feasibility of integrating wearable monitoring with tDCS protocols and warrant further validation in randomized sham-controlled trials. CI - (c)Sehwan Park, Gangho Do, Jaesub Park, Min-Kyoung Kim, Sra Jung, Hyun-Ju Kim, Hee Young Cho. Originally published in JMIR Formative Research (https://formative.jmir.org), 12.03.2026. FAU - Park, Sehwan AU - Park S AUID- ORCID: 0000-0002-4355-7453 AD - Medical Research Team, Digital Medic Co, Ltd, Seoul, Republic of Korea. FAU - Do, Gangho AU - Do G AUID- ORCID: 0009-0003-7314-1760 AD - Digital Medic Co, Ltd, Seoul, Republic of Korea. FAU - Park, Jaesub AU - Park J AUID- ORCID: 0000-0003-2597-2204 AD - Department of Psychiatry, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Seoul, Republic of Korea. FAU - Kim, Min-Kyoung AU - Kim MK AUID- ORCID: 0000-0002-5596-5665 AD - Department of Psychiatry, CHA Ilsan Medical Center, CHA University, Goyang-si, Gyeonggi-do, Republic of Korea. FAU - Jung, Sra AU - Jung S AUID- ORCID: 0000-0001-5510-0680 AD - Department of Psychiatry, CHA Ilsan Medical Center, CHA University, Goyang-si, Gyeonggi-do, Republic of Korea. FAU - Kim, Hyun-Ju AU - Kim HJ AUID- ORCID: 0000-0002-8093-3366 AD - Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, Republic of Korea. FAU - Cho, Hee Young AU - Cho HY AUID- ORCID: 0000-0001-7064-5056 AD - Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea. AD - Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Seoul, Republic of Korea. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260312 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - Female MH - Pilot Projects MH - Adult MH - *Transcranial Direct Current Stimulation/methods/standards MH - *Depression/therapy/psychology MH - Pregnancy MH - Feasibility Studies MH - Treatment Outcome PMC - PMC13022536 OTO - NOTNLM OT - behavioral activation OT - digital phenotyping OT - perinatal depression OT - pilot study OT - tDCS OT - transcranial direct current stimulation OT - wearable devices COIS- Conflicts of Interest: None declared. EDAT- 2026/03/12 18:53 MHDA- 2026/03/12 18:54 PMCR- 2026/03/12 CRDT- 2026/03/12 16:53 PHST- 2025/11/18 00:00 [received] PHST- 2026/02/05 00:00 [accepted] PHST- 2026/02/04 00:00 [revised] PHST- 2026/03/12 18:54 [medline] PHST- 2026/03/12 18:53 [pubmed] PHST- 2026/03/12 16:53 [entrez] PHST- 2026/03/12 00:00 [pmc-release] AID - v10i1e56454 [pii] AID - 10.2196/56454 [doi] PST - epublish SO - JMIR Form Res. 2026 Mar 12;10:e56454. doi: 10.2196/56454. PMID- 41817871 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Mar 12 TI - Relationship between obsessive personality traits and eating disorders. LID - 10.1007/s40519-026-01829-5 [doi] LID - 48 AB - This study aimed to examine associations between obsessive personality traits (perfectionism, desire for control, and cognitive flexibility) and eating-related symptomatology in a non-clinical sample of young adults. The objective was to explore which subdimensions were most strongly associated with eating attitudes. A cross-sectional study was conducted with 890 students aged 18-25 years, who completed validated self-report measures: the Eating Attitudes Test (EAT-26) (Garner and Garfinkel in Psychol Med 9(2):273-279, 1979), the Frost Multidimensional Perfectionism Scale (FMPS) (Frost et al. in Cognit Ther Res 14(5):449-468, 1990), the Desirability of Control Scale (Burger and Cooper in Motiv Emot 3(4):381-393, 1979), and the Personalised Psychological Flexibility Index (PPFI) (Kashdan et al. in Psychol Assess 32(9):829-850, 2020). Regression analyses were conducted controlling for sex and age. The results indicated statistically significant but modest associations between several subdimensions of perfectionism, cognitive flexibility, desire for control, and eating-related symptomatology. These findings expand the previous evidence on obsessive personality traits in relation to eating behaviours and should be interpreted as exploratory and correlational in nature.Level of evidence: 2 (observational, cross-sectional study). CI - (c) 2026. The Author(s). FAU - Triguero-Lopez, Maria J AU - Triguero-Lopez MJ AUID- ORCID: 0000-0002-2975-9534 AD - Department of Personality, Psychological Assessment, and Treatment, Faculty of Psychology, University of Seville, Calle Camilo Jose Cela, 41018, Seville, Spain. martrilop@alum.us.es. FAU - Moreno-Garcia, M Inmaculada AU - Moreno-Garcia MI AUID- ORCID: 0000-0002-6335-9200 AD - Department of Personality, Psychological Assessment, and Treatment, Faculty of Psychology, University of Seville, Calle Camilo Jose Cela, 41018, Seville, Spain. FAU - Morales-Ortiz, Manuel AU - Morales-Ortiz M AUID- ORCID: 0000-0002-2690-2542 AD - Department of Experimental Psychology, Faculty of Psychology, University of Seville, Calle Camilo Jose Cela, 41018, Seville, Spain. LA - eng PT - Journal Article DEP - 20260312 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - Young Adult MH - Cross-Sectional Studies MH - Female MH - Adolescent MH - Cognitive Flexibility MH - *Perfectionism MH - *Feeding and Eating Disorders/psychology MH - *Personality/physiology MH - Male MH - Adult MH - *Obsessive Behavior/psychology MH - *Feeding Behavior/psychology PMC - PMC13216079 OTO - NOTNLM OT - Cognitive flexibility OT - Desire for control OT - Eating disorders OT - Obsessive personality OT - Perfectionism COIS- Declarations. Ethics approval and consent to participate: This study was approved by the University of Seville Ethics Committee for research involving human subjects. Informed consent was obtained from all participants prior to data collection, in compliance with the ethical principles of the Declaration of Helsinki. Informed consent was obtained from all individual participants included in the study. Competing interests: The authors declare no competing interests. EDAT- 2026/03/12 18:52 MHDA- 2026/05/28 00:30 PMCR- 2026/03/12 CRDT- 2026/03/12 12:21 PHST- 2025/08/27 00:00 [received] PHST- 2026/02/16 00:00 [accepted] PHST- 2026/05/28 00:30 [medline] PHST- 2026/03/12 18:52 [pubmed] PHST- 2026/03/12 12:21 [entrez] PHST- 2026/03/12 00:00 [pmc-release] AID - 10.1007/s40519-026-01829-5 [pii] AID - 1829 [pii] AID - 10.1007/s40519-026-01829-5 [doi] PST - epublish SO - Eat Weight Disord. 2026 Mar 12;31(1):48. doi: 10.1007/s40519-026-01829-5. PMID- 41817479 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 1878-2620 (Electronic) IS - 1499-4046 (Print) IS - 1499-4046 (Linking) VI - 58 IP - 6 DP - 2026 Jun TI - More PEAS Please! Implementation Methodology of a Preschool Program Promoting Healthy Eating, Science, and Language. PG - 603-615 LID - S1499-4046(26)00005-9 [pii] LID - 10.1016/j.jneb.2026.01.006 [doi] AB - OBJECTIVE: Preschool Education in Applied Sciences (PEAS) intervention, a multicomponent intervention designed to improve teachers' science teaching self-efficacy and enhance children's fruit and vegetable consumption, science knowledge, and language development. DESIGN: A 2-group (comparison/delayed intervention) quasi-experimental design was employed. Teachers completed baseline, formative, and postintervention surveys. Intervention teachers also completed a postintervention interview. Child outcomes were assessed at 3 timepoints (baseline, preintervention, and postintervention) using validated measures. SETTING: Thirteen Head Start centers in central North Carolina. PARTICIPANTS: Ninety-four teachers (n = 44 intervention; n = 50 comparison) and 330 English-speaking children aged 3-5 years (n = 140 intervention; n = 190 comparison), based on power analysis estimates. INTERVENTION: Components included a 1-day Kick-Starter Workshop, 6 eLearning modules, PEAS teaching guide featuring 12 classroom activities, and center-based implementation supports including individualized coaching, peer learning communities, and farm to early care and education resources. MAIN OUTCOME MEASURES: Teacher outcomes included self-reported teaching self-efficacy. Child outcomes include fruit and vegetable consumption (skin carotenoids via Veggie Meter(R)), height/weight, science knowledge, and academic vocabulary. ANALYSIS: Quantitative data were analyzed using descriptive statistics, paired t tests, Wilcoxon signed-rank tests, and regression models. Qualitative data were analyzed phenomenologically. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Stage, Virginia C AU - Stage VC AD - Department of Agricultural and Human Sciences, North Carolina State University, North Carolina State Extension, Raleigh, NC. Electronic address: virginia_stage@ncsu.edu. FAU - Dixon, Jocelyn B AU - Dixon JB AD - Department of Agricultural and Human Sciences, North Carolina State University, North Carolina State Extension, Raleigh, NC. FAU - Lundquist, Ryan AU - Lundquist R AD - Department of Agricultural and Human Sciences, North Carolina State University, North Carolina State Extension, Raleigh, NC. FAU - Wu, Qiang AU - Wu Q AD - Department of Public Health, East Carolina University, Greenville, NC. FAU - Hegde, Archana V AU - Hegde AV AD - Department of Human Development and Family Science, College of Health and Human Performance, East Carolina University, Greenville, NC. FAU - Lee, Tammy D AU - Lee TD AD - Department of Mathematics, Science, and Instructional Technology Education, College of Education, East Carolina University, Greenville, NC. FAU - Grist, Pauline AU - Grist P AD - Department of Agricultural and Human Sciences, North Carolina State University, North Carolina State Extension, Raleigh, NC. FAU - Goodell, L Suzanne AU - Goodell LS AD - Department of Food, Bioprocessing, and Nutrition Sciences, North Carolina State University Extension, Raleigh, NC. LA - eng GR - R25 GM132939/GM/NIGMS NIH HHS/United States PT - Journal Article DEP - 20260311 PL - United States TA - J Nutr Educ Behav JT - Journal of nutrition education and behavior JID - 101132622 SB - IM MH - Humans MH - Child, Preschool MH - *Diet, Healthy/methods MH - *Health Promotion/methods MH - North Carolina MH - Female MH - Male MH - Fruit MH - Vegetables MH - Self Efficacy MH - Health Knowledge, Attitudes, Practice PMC - PMC13363033 MID - NIHMS2189666 OTO - NOTNLM OT - Head Start OT - STEAM OT - food-based learning OT - fruit and vegetable consumption OT - preschool COIS- CONFLICT OF INTEREST DISCLOSURE The authors have not stated any conflicts of interest. EDAT- 2026/03/12 13:56 MHDA- 2026/06/15 11:35 PMCR- 2026/07/13 CRDT- 2026/03/12 11:27 PHST- 2025/04/08 00:00 [received] PHST- 2026/01/06 00:00 [revised] PHST- 2026/01/08 00:00 [accepted] PHST- 2026/06/15 11:35 [medline] PHST- 2026/03/12 13:56 [pubmed] PHST- 2026/03/12 11:27 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - S1499-4046(26)00005-9 [pii] AID - 10.1016/j.jneb.2026.01.006 [doi] PST - ppublish SO - J Nutr Educ Behav. 2026 Jun;58(6):603-615. doi: 10.1016/j.jneb.2026.01.006. Epub 2026 Mar 11. PMID- 41817418 OWN - NLM STAT- MEDLINE DCOM- 20260607 LR - 20260607 IS - 1099-0968 (Electronic) IS - 1072-4133 (Linking) VI - 34 IP - 4 DP - 2026 Jul TI - Psychometric Properties of the Commitment to Exercise Scale in Inpatients With Anorexia Nervosa and Bulimia Nervosa. PG - 1121-1129 LID - 10.1002/erv.70099 [doi] AB - OBJECTIVE: Compulsive exercise is a common behaviour among persons with eating disorders, particularly in those with anorexia nervosa (AN) and bulimia nervosa (BN). In the current study, we examined psychometric properties of a German version of the eight-item Commitment to Exercise Scale (CES) with a four-point scale response format. METHOD: Data of N = 2424 persons with AN and BN who completed the CES among other measures as part of the routine diagnostic assessment at admission to and discharge from inpatient treatment were analysed based on a preregistered protocol (https://doi.org/10.17605/OSF.IO/Z2RYW). RESULTS: The CES had high internal consistency and a one-factor structure with measurement invariance across age and diagnostic groups. Large correlations with other measures of compulsive exercise supported convergent validity and small-to-moderate correlations with other measures supported divergent validity. Scores on the CES were sensitive to change as they moderately decreased during inpatient treatment, with changes in compulsive exercise being larger in males and persons with AN that in females and persons with BN. CONCLUSIONS: The CES has sound psychometric properties in persons with AN and BN. Given its brevity, it may be favoured over lengthier instruments for assessing compulsive exercise in research and clinical practice. CI - (c) 2026 The Author(s). European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd. FAU - Fabry, Fiona M AU - Fabry FM AUID- ORCID: 0009-0004-7646-4255 AD - Department of Psychology, University of Regensburg, Regensburg, Germany. FAU - Schlegl, Sandra AU - Schlegl S AUID- ORCID: 0000-0003-1791-7379 AD - Department of Psychiatry and Psychotherapy, LMU University Hospital, Munich, Germany. FAU - Dittmer, Nina AU - Dittmer N AUID- ORCID: 0000-0001-6679-4905 AD - Schoen Clinic Roseneck, Prien am Chiemsee, Germany. FAU - Voderholzer, Ulrich AU - Voderholzer U AUID- ORCID: 0000-0003-0261-3145 AD - Department of Psychiatry and Psychotherapy, LMU University Hospital, Munich, Germany. AD - Schoen Clinic Roseneck, Prien am Chiemsee, Germany. AD - Department of Psychiatry and Psychotherapy, University Hospital of Freiburg, Freiburg im Breisgau, Germany. FAU - Kolar, David R AU - Kolar DR AUID- ORCID: 0000-0002-8649-5467 AD - Department of Psychology, University of Regensburg, Regensburg, Germany. FAU - Meule, Adrian AU - Meule A AUID- ORCID: 0000-0002-6639-8977 AD - Department of Psychology, University of Regensburg, Regensburg, Germany. LA - eng PT - Journal Article DEP - 20260312 PL - England TA - Eur Eat Disord Rev JT - European eating disorders review : the journal of the Eating Disorders Association JID - 9436977 SB - IM MH - Humans MH - Female MH - Psychometrics MH - *Anorexia Nervosa/psychology MH - *Bulimia Nervosa/psychology MH - Inpatients/psychology MH - Adult MH - Reproducibility of Results MH - Male MH - Young Adult MH - Adolescent MH - *Exercise/psychology MH - *Compulsive Exercise/psychology/diagnosis MH - Surveys and Questionnaires MH - Middle Aged OTO - NOTNLM OT - assessment OT - compulsive exercise OT - driven exercise OT - eating disorders OT - excessive exercise EDAT- 2026/03/12 13:57 MHDA- 2026/06/07 06:33 CRDT- 2026/03/12 10:53 PHST- 2026/02/22 00:00 [revised] PHST- 2025/11/26 00:00 [received] PHST- 2026/03/05 00:00 [accepted] PHST- 2026/06/07 06:33 [medline] PHST- 2026/03/12 13:57 [pubmed] PHST- 2026/03/12 10:53 [entrez] AID - 10.1002/erv.70099 [doi] PST - ppublish SO - Eur Eat Disord Rev. 2026 Jul;34(4):1121-1129. doi: 10.1002/erv.70099. Epub 2026 Mar 12. PMID- 41816798 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260827 IS - 1879-3479 (Electronic) IS - 0020-7292 (Print) IS - 0020-7292 (Linking) VI - 174 IP - 3 DP - 2026 Sep TI - Impact of active phase duration on neonatal and maternal adverse outcomes: A systematic analysis of parity stratification, body mass index interaction, and predictive modeling in a retrospective cohort. PG - 1350-1363 LID - 10.1002/ijgo.70932 [doi] AB - BACKGROUND: A prolonged active phase of labor is associated with adverse maternal and neonatal outcomes, but its clinical significance in contemporary obstetric populations, including the unique Chinese demographic context, and its modification by parity and body mass index (BMI) remain incompletely defined. METHODS: A single-center retrospective cohort study included 2873 women with term (>/=37 weeks), singleton, cephalic vaginal deliveries. Active phase duration (defined as time from 5 cm to 10 cm cervical dilation) was categorized into short, medium, and prolonged groups (33rd/66th percentiles). Multivariable logistic regression and restricted cubic spline (RCS) analyses were used to adjust for confounders, test interactions, and explore nonlinear trends. Predictive models incorporating active phase duration, parity, and clinical covariates were validated using area under the receiver operating characteristic curve (AUC). Primary outcomes were composite neonatal morbidity and composite maternal morbidity. Secondary outcomes included individual neonatal (e.g., neonatal intensive care unit admission and fetal distress) and maternal (e.g., postpartum hemorrhage) outcomes. RESULTS: Among nulliparous women, prolonged active phase duration significantly increased risks of composite neonatal morbidity (adjusted odds ratio [aOR] 2.08, 95% confidence interval [CI] 1.23-3.52; P = 0.006), neonatal intensive care unit admission (aOR 1.97, 95% CI 1.06-3.67; P = 0.032), fetal distress (aOR 2.47, 95% CI 1.37-4.44; P = 0.003), postpartum hemorrhage (aOR 1.62, 95% CI 1.09-2.41; P = 0.018), and composite maternal morbidity (aOR 1.74, 95% CI 1.18-2.56; P = 0.005). No significant associations were observed in multiparous women. BMI modified these relationships (P interaction <0.05), with the highest risk observed in women with BMI 24.9-27.1 kg/m(2). A nonlinear J-shaped association was identified for maternal morbidity (inflection point: 60.1 min). Predictive models demonstrated robust discrimination (AUC: 0.72-0.78) for adverse outcomes. CONCLUSION: Prolonged active phase duration independently predicts maternal and neonatal morbidity in nulliparous women, with risk amplification in specific BMI subgroups. Parity stratification and nonlinear modeling enhance individualized labor management. Clinically applicable predictive tools integrating labor progression and maternal characteristics might optimize early intervention, reducing morbidity in modern obstetric practice. CI - (c) 2026 International Federation of Gynecology and Obstetrics. FAU - Peng, Li AU - Peng L AD - Department of Obstetrics and Gynecology, the Second Xiangya Hospital, Central South University, Changsha, China. AD - Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. FAU - Zhang, Tingting AU - Zhang T AD - Department of Obstetrics and Gynecology, the Second Xiangya Hospital, Central South University, Changsha, China. FAU - Li, Yifan AU - Li Y AD - Department of Obstetrics and Gynecology, the Second Xiangya Hospital, Central South University, Changsha, China. FAU - Liu, Hongyu AU - Liu H AD - Department of Obstetrics and Gynecology, the Second Xiangya Hospital, Central South University, Changsha, China. FAU - Zhang, Jun AU - Zhang J AD - Department of Obstetrics and Gynecology, the Second Xiangya Hospital, Central South University, Changsha, China. FAU - Fang, Xiaoling AU - Fang X AD - Department of Obstetrics and Gynecology, the Second Xiangya Hospital, Central South University, Changsha, China. FAU - Wu, Jingni AU - Wu J AUID- ORCID: 0000-0003-2781-8622 AD - Department of Obstetrics and Gynecology, the Second Xiangya Hospital, Central South University, Changsha, China. LA - eng GR - 82201821/the National Natural Science Foundation of China/ GR - 2023JJ40859/Natural Science Foundation of Hunan Province/ PT - Journal Article DEP - 20260312 PL - United States TA - Int J Gynaecol Obstet JT - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics JID - 0210174 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Retrospective Studies MH - *Body Mass Index MH - *Parity MH - Adult MH - Infant, Newborn MH - *Pregnancy Outcome/epidemiology MH - *Labor Stage, First/physiology MH - Postpartum Hemorrhage/epidemiology/etiology MH - Delivery, Obstetric MH - Logistic Models MH - Time Factors MH - *Obstetric Labor Complications/epidemiology MH - Risk Factors MH - China/epidemiology PMC - PMC13505256 OTO - NOTNLM OT - active phase duration OT - body mass index OT - neonatal outcomes OT - parity maternal morbidity OT - predictive modeling COIS- The authors confirm that there are no conflicts of interest. EDAT- 2026/03/12 07:03 MHDA- 2026/08/25 11:38 PMCR- 2026/08/25 CRDT- 2026/03/12 05:21 PHST- 2026/02/11 00:00 [revised] PHST- 2025/09/18 00:00 [received] PHST- 2026/02/18 00:00 [accepted] PHST- 2026/08/25 11:38 [medline] PHST- 2026/03/12 07:03 [pubmed] PHST- 2026/03/12 05:21 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - IJGO70932 [pii] AID - 10.1002/ijgo.70932 [doi] PST - ppublish SO - Int J Gynaecol Obstet. 2026 Sep;174(3):1350-1363. doi: 10.1002/ijgo.70932. Epub 2026 Mar 12. PMID- 41816677 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260312 LR - 20260813 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 13 DP - 2026 TI - A novel dual elastography-based model for screening high-risk varices in hepatitis B virus-related cirrhosis. PG - 1707998 LID - 10.3389/fmed.2026.1707998 [doi] LID - 1707998 AB - BACKGROUND AND OBJECTIVE: Variceal bleeding carries high mortality and recurrence rates, underscoring the urgent need for effective non-invasive tests (NITs) to assess the severity of esophageal varices (EVs) and predict bleeding risk. This study aimed to develop and validate a robust model for safely excluding high-risk varices (HRVs) in patients with hepatitis B virus (HBV)-related cirrhosis and to compare its diagnostic performance and clinical utility with established NITs. METHODS: Consecutive patients with HBV-related cirrhosis were prospectively recruited from five centers and underwent dual elastography (dual-elasto) within 1 week of esophagogastroduodenoscopy (EGD). A training cohort from four centers was used to identify predictive variables for HRVs, which were analyzed using machine learning to develop the most reliable model. The final model was externally validated in an independent cohort from the fifth center. Diagnostic efficacy and clinical utility were compared across multiple NITs, including the Baveno VI criteria (B6C), expanded Baveno VI criteria (EB6C), platelet-spleen ratio (PSR), and RESIST-HCV criteria (RESIST). RESULTS: Among 703 screened patients, 328 were enrolled (training cohort n = 184; validation cohort n = 144). Using logistic regression, we developed the DELU model incorporating six variables: platelet count (PLT), alanine aminotransferase (ALT), ascites, portal vein thrombosis (PVT), inverse difference moment (IDM), and liver stiffness (liver Vs). DELU achieved areas under the receiver operating characteristic curve (AUROCs) of 0.822 (training) and 0.779 (validation), outperforming RESIST (0.600 and 0.626) and B6C (0.569 and 0.575). EB6C and PSR were excluded because they exceeded the 5% missed-HRV threshold. DELU demonstrated the highest spared-EGD rates (20.7% training; 11.1% validation) and maintained robust performance across subgroups, including Child-Pugh B/C (AUROC 80.3%), Child-Pugh A (79.7%), antiviral therapy (ART)-treated (82.5%), and virologically suppressed patients (84.6%). Performance was not influenced by hepatocellular carcinoma (HCC) status, sex, or body mass index (BMI). CONCLUSION: DELU is a reliable and safe non-invasive tool for excluding HRVs in HBV-related cirrhosis, providing superior diagnostic accuracy and significant endoscopy-sparing potential across diverse clinical settings. RESIST may serve as a safe alternative when elastography is unavailable. CLINICAL TRIAL REGISTRATION: [ClinicalTrials.gov], identifier [NCT04640350]. CI - Copyright (c) 2026 Hu, Chen, Zheng, Yang, Zhang, Zhang, Yin, Liao, Tang, Yu, Liang and Meng. FAU - Hu, Xing AU - Hu X AD - Center of Ultrasound and Functional Diagnosis, Beijing Youan Hospital, Capital Medical University, Beijing, China. FAU - Chen, Min AU - Chen M AD - Department of Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China. FAU - Zheng, Ying AU - Zheng Y AD - Center of Ultrasound and Functional Diagnosis, Beijing Youan Hospital, Capital Medical University, Beijing, China. FAU - Yang, Xiuhua AU - Yang X AD - Department of Interventional Ultrasound, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. FAU - Zhang, Wei AU - Zhang W AD - Department of Interventional Ultrasound, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. FAU - Zhang, Yao AU - Zhang Y AD - Department of Ultrasound, Beijing Ditan Hospital, Capital Medical University, Beijing, China. FAU - Yin, Zhiyong AU - Yin Z AD - Department of Ultrasound, Beijing Ditan Hospital, Capital Medical University, Beijing, China. FAU - Liao, Jintang AU - Liao J AD - Department of Ultrasound, Xiangya Hospital, Central South University, Changsha, Hunan, China. FAU - Tang, Yangshuo AU - Tang Y AD - Department of Ultrasound, Xiangya Hospital, Central South University, Changsha, Hunan, China. FAU - Yu, Jie AU - Yu J AD - Department of Interventional Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China. FAU - Liang, Ping AU - Liang P AD - Department of Interventional Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China. FAU - Meng, Fankun AU - Meng F AD - Center of Ultrasound and Functional Diagnosis, Beijing Youan Hospital, Capital Medical University, Beijing, China. LA - eng SI - ClinicalTrials.gov/NCT04640350 PT - Clinical Trial PT - Journal Article DEP - 20260224 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC12971904 OTO - NOTNLM OT - cirrhosis OT - dual elastography OT - hepatitis B OT - high-risk varices OT - non-invasive test COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/12 07:03 MHDA- 2026/03/12 07:04 PMCR- 2026/02/24 CRDT- 2026/03/12 05:19 PHST- 2025/09/18 00:00 [received] PHST- 2025/12/20 00:00 [revised] PHST- 2026/01/20 00:00 [accepted] PHST- 2026/03/12 07:04 [medline] PHST- 2026/03/12 07:03 [pubmed] PHST- 2026/03/12 05:19 [entrez] PHST- 2026/02/24 00:00 [pmc-release] AID - 10.3389/fmed.2026.1707998 [doi] PST - epublish SO - Front Med (Lausanne). 2026 Feb 24;13:1707998. doi: 10.3389/fmed.2026.1707998. eCollection 2026. PMID- 41816243 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260312 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Prenatal exposure to metal mixtures and the risk of overweight and obesity in school-aged children: insights from metabolomic profiling. PG - 1762885 LID - 10.3389/fnut.2026.1762885 [doi] LID - 1762885 AB - BACKGROUND: Prenatal metal mixtures exposure was associated with child growth. However, long-term impact of maternal metal mixture exposure on offspring's overweight or obesity (OWO) in childhood and the potential role of metabolites remain poorly understood. METHODS: Based on a prospective cohort study, ten metals were measured and metabolomics profiling was conducted in maternal serum during pregnancy. Children's anthropometric parameters were measured at school age and OWO was defined according to the international World Health Organization (WHO) reference data. A combination of multiple regression models, variable selection models and exposome models were conducted to explore the effects of prenatal metal mixture exposure on child OWO and BMI z-score. A meet-in-the-middle (MITM) approach was employed to examine metabolites' potential role in mediating this association. RESULTS: Maternal metals exposure such as Cu and V was found to be positively associated with OWO risk based on single-metal models, with ORs being 24.171 (95% CI: 2.351-403.256) and 2.534 (95% CI: 1.273-5.623), respectively. Similarly, prenatal exposure to V was also positively associated with BMI z-scores in school-aged children (beta: 0.293, 95% CI: 0.015-0.572). Marginal association was found between Cu exposure and BMI z-scores (beta: 0.758, 95% CI: -0.001-1.517). Metabolites such as glycerophosphocholine and glycine played potential intermediate roles in the association between maternal Cu levels and OWO risk. CONCLUSION: Prenatal Cu and V exposure may have an adverse effect on school-aged childhood's OWO risk, and metabolites may play an important intermediate role. By further examining metabolite profiles, our findings offer insight into potential metabolic pathways through which prenatal metal exposure may influence childhood obesity risk, thereby extending existing epidemiological evidence with a mechanistic perspective. Multi-center population studies and in vivo studies in future are needed to validate the results. CI - Copyright (c) 2026 Yang, Sun, Yan, Zhang, Bao, Lv, Guan, Yu and Xia. FAU - Yang, Xu AU - Yang X AD - Department of Pediatrics, Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China. FAU - Sun, Xian AU - Sun X AD - Preventive Health Care Department, Ligang Hospital of Jiangyin City, Wuxi, China. FAU - Yan, Chun AU - Yan C AD - Department of Pediatrics, Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China. FAU - Zhang, Wen AU - Zhang W AD - Department of Pediatrics, Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China. FAU - Bao, Lili AU - Bao L AD - Department of Pediatrics, Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China. FAU - Lv, YuWen AU - Lv Y AD - Department of Pediatrics, Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China. FAU - Guan, Quanquan AU - Guan Q AD - State Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University, Nanjing, China. AD - Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Yu, Yanyan AU - Yu Y AD - Department of Pediatrics, Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China. FAU - Xia, Yankai AU - Xia Y AD - State Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University, Nanjing, China. AD - Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China. LA - eng PT - Journal Article DEP - 20260224 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12971668 OTO - NOTNLM OT - children OT - metabolomics OT - metal mixture OT - overweight and obesity OT - pregnancy COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/12 07:03 MHDA- 2026/03/12 07:04 PMCR- 2026/02/24 CRDT- 2026/03/12 05:15 PHST- 2025/12/08 00:00 [received] PHST- 2026/01/30 00:00 [revised] PHST- 2026/02/02 00:00 [accepted] PHST- 2026/03/12 07:04 [medline] PHST- 2026/03/12 07:03 [pubmed] PHST- 2026/03/12 05:15 [entrez] PHST- 2026/02/24 00:00 [pmc-release] AID - 10.3389/fnut.2026.1762885 [doi] PST - epublish SO - Front Nutr. 2026 Feb 24;13:1762885. doi: 10.3389/fnut.2026.1762885. eCollection 2026. PMID- 41815964 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Nutrition literacy and socio-demographic determinants among Chinese women of childbearing age. PG - 1742415 LID - 10.3389/fpubh.2026.1742415 [doi] LID - 1742415 AB - BACKGROUND: Nutrition literacy is critical for women of childbearing age because it may shape dietary behaviors before and during pregnancy. Evidence on domain-specific nutrition literacy and associated factors in China remains limited. METHODS: A cross-sectional online survey was conducted from August 20, 2024 to March 20, 2025, with dissemination supported by three tertiary hospitals in East, North, and Middle China. Women aged 18-49 years completed an adapted Chinese Nutrition Literacy Questionnaire (CNLQ). Domain and total scores were calculated using the original protocol and transformed to a 0-100 scale, with higher scores indicating higher nutrition literacy. Adequate nutrition literacy was defined as total score >/=80. Psychometric evaluation of the adapted instrument was performed in the full analytic sample. Univariable screening (p < 0.10) was used to select predictors for multivariable linear regression (total score) and multivariable logistic regression (adequacy). RESULTS: Among 1,764 returned questionnaires, 1,391 were included after exclusions. Mean total nutrition literacy was 74.9 +/- 12.8, and 33.4% (n = 465) met the adequacy threshold. Domain scores showed a gradient: functional 77.4 +/- 13.4, interactive 75.1 +/- 13.8, and critical 69.9 +/- 14.2. In adjusted models, higher education, higher income, urban residence, and healthcare background were associated with higher total scores and higher odds of adequacy. Multimorbidity was associated with lower total score (adjusted beta = -2.55) and lower odds of adequacy (adjusted OR = 0.62). Women aged 35-49 years had higher total scores (adjusted beta = 1.67) and higher odds of adequacy (adjusted OR = 1.43) compared with those aged 18-24 years. CONCLUSION: Nutrition literacy among Chinese women of childbearing age is moderate, with critical literacy lowest. Socioeconomic factors, urban residence, healthcare background, and multimorbidity are key correlates, highlighting priorities for targeted interventions that strengthen critical appraisal skills and support women with multimorbidity. CI - Copyright (c) 2026 Meng, Chen, Pu, Zhu, Zuo, Wang, Chang, He, Zhang, Bai, Sun, Liu and Shi. FAU - Meng, Jing-Jing AU - Meng JJ AD - Department of Gynaecology and Obstetrics, The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital), Suzhou, China. FAU - Chen, Jun AU - Chen J AD - Medical Services Management Department, Peking University People's Hospital, Beijing, China. FAU - Pu, Li AU - Pu L AD - Department of Gynaecology and Obstetrics, The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital), Suzhou, China. FAU - Zhu, Yan AU - Zhu Y AD - Center for Health Statistics and Information, National Health Commission of People's Republic of China, Beijing, China. FAU - Zuo, Yan AU - Zuo Y AD - Department of Gynecology and Obstetrics Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. AD - West China School of Nursing, Sichuan University, Chengdu, Sichuan, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. FAU - Wang, Fang AU - Wang F AD - Zoucheng People's Hospital, Zoucheng, China. FAU - Chang, Li AU - Chang L AD - Hospital Management Center, Shulan Health Group, Hangzhou, China. FAU - He, Yi-Ying AU - He YY AD - Neonatal Intensive Care Unit, Children's Hospital of Soochow University, Suzhou, China. FAU - Zhang, Jian-Jun AU - Zhang JJ AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. AD - Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Bai, Zhi-Lan AU - Bai ZL AD - Department of Gynecology and Obstetrics Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. AD - West China School of Nursing, Sichuan University, Chengdu, Sichuan, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. FAU - Sun, Si-Qin AU - Sun SQ AD - Endocrinology Department, Zoucheng People's Hospital, Zoucheng, China. FAU - Liu, Jie AU - Liu J AD - Endocrinology Department, Zoucheng People's Hospital, Zoucheng, China. FAU - Shi, Jia AU - Shi J AD - Department of Gynaecology and Obstetrics, The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital), Suzhou, China. LA - eng PT - Journal Article DEP - 20260224 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - Chinese people SB - IM MH - Humans MH - Female MH - Adult MH - *Health Literacy/statistics & numerical data MH - China MH - Cross-Sectional Studies MH - Middle Aged MH - Adolescent MH - Young Adult MH - Socioeconomic Factors MH - Surveys and Questionnaires MH - Sociodemographic Factors MH - *Nutritional Status MH - East Asian People PMC - PMC12974174 OTO - NOTNLM OT - China OT - maternal health OT - nutrition literacy OT - reproductive health OT - socio-demographic determinants OT - women of childbearing age COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/12 07:03 MHDA- 2026/03/12 13:55 PMCR- 2026/02/24 CRDT- 2026/03/12 05:13 PHST- 2025/11/09 00:00 [received] PHST- 2026/02/05 00:00 [revised] PHST- 2026/02/05 00:00 [accepted] PHST- 2026/03/12 13:55 [medline] PHST- 2026/03/12 07:03 [pubmed] PHST- 2026/03/12 05:13 [entrez] PHST- 2026/02/24 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1742415 [doi] PST - epublish SO - Front Public Health. 2026 Feb 24;14:1742415. doi: 10.3389/fpubh.2026.1742415. eCollection 2026. PMID- 41814473 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260825 IS - 2090-1844 (Electronic) IS - 2090-1836 (Print) IS - 2090-1844 (Linking) VI - 2026 IP - 1 DP - 2026 TI - Impact of Post-COVID Syndrome on Cardiorespiratory Fitness, Psychological Well-Being, and Quality of Life in Adolescents: A Cross-Sectional Study. PG - e5599011 LID - 10.1155/pm/5599011 [doi] LID - 5599011 AB - BACKGROUND: Post-COVID syndrome (PCS) in adolescents, marked by persistent symptoms such as dyspnea and fatigue, remains poorly understood, particularly in those referred for exercise intolerance. OBJECTIVE: The objective of this study is to describe the clinical presentation and cardiorespiratory fitness (CRF) of adolescents with PCS and identify factors distinguishing those with normal versus reduced CRF. STUDY DESIGN: In this cross-sectional study, 31 adolescents (90% female) with PCS underwent cardiopulmonary exercise testing (CPET), pulmonary function tests, and completed validated questionnaires assessing fatigue, depression, hyperventilation, physical activity, and quality of life (QoL). Patients were grouped by CRF status and compared. RESULTS: Symptoms were more prevalent than in general PCS literature, likely due to referral bias. Moderate depression risk was present in 35%, and 75% reported QoL impairment comparable with chronic conditions. Nearly half (48%) had reduced CRF. CRF was not associated with acute infection severity but correlated with orthostatism, reduced O(2) pulse, and increased static air trapping (p < 0.05). Preinfection physical activity was positively associated with CRF (p = 0.014), whereas postinfection activity levels were similar across groups. CONCLUSION: PCS significantly impacts CRF, QoL, and psychological well-being in adolescents with exercise intolerance. Reduced CRF appears multifactorial, involving autonomic dysfunction, pulmonary limitations, and deconditioning. These findings underscore the need for comprehensive evaluation and targeted management strategies in this vulnerable population. CI - Copyright (c) 2026 Albane Bertha Rosa Maggio et al. Pulmonary Medicine published by John Wiley & Sons Ltd. FAU - Maggio, Albane Bertha Rosa AU - Maggio ABR AUID- ORCID: 0000-0002-9110-4467 AD - Department of Pediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland, hug-ge.ch. FAU - Perret, Ivan AU - Perret I AD - Faculty of Medicine, University of Geneva, Geneva, Switzerland, unige.ch. FAU - Alramadina, Nuseibah AU - Alramadina N AD - Department of Pediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland, hug-ge.ch. FAU - Perrin, Anne AU - Perrin A AD - Department of Pediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland, hug-ge.ch. FAU - Barazzone, Constance AU - Barazzone C AD - Department of Pediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland, hug-ge.ch. FAU - Mornand, Anne AU - Mornand A AD - Department of Pediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland, hug-ge.ch. LA - eng GR - Universite de GeneveFund source/ GR - CSAL/ PT - Journal Article PL - United States TA - Pulm Med JT - Pulmonary medicine JID - 101558762 SB - IM MH - Humans MH - Adolescent MH - *Quality of Life MH - Cross-Sectional Studies MH - Female MH - *Cardiorespiratory Fitness/physiology/psychology MH - Post-Acute COVID-19 Syndrome MH - *COVID-19/complications/psychology/physiopathology MH - Exercise Test/methods MH - Male MH - Respiratory Function Tests/methods MH - Fatigue/etiology/physiopathology MH - Psychological Well-Being MH - SARS-CoV-2 MH - Depression/etiology/epidemiology MH - Dyspnea/etiology/physiopathology MH - Pandemics MH - Exercise MH - Hyperventilation/etiology PMC - PMC13140234 OTO - NOTNLM OT - breathing pattern OT - cardiorespiratory exercise test OT - cardiorespiratory fitness OT - dysfunctional breathing OT - peak oxygen consumption OT - post- syndrome OT - pulmonary function COIS- The authors declare no conflicts of interest. EDAT- 2026/03/12 07:04 MHDA- 2026/03/12 13:55 PMCR- 2026/03/11 CRDT- 2026/03/12 01:09 PHST- 2026/01/16 00:00 [revised] PHST- 2025/12/04 00:00 [received] PHST- 2026/02/17 00:00 [accepted] PHST- 2026/03/12 13:55 [medline] PHST- 2026/03/12 07:04 [pubmed] PHST- 2026/03/12 01:09 [entrez] PHST- 2026/03/11 00:00 [pmc-release] AID - PM5599011 [pii] AID - 10.1155/pm/5599011 [doi] PST - ppublish SO - Pulm Med. 2026;2026(1):e5599011. doi: 10.1155/pm/5599011. PMID- 41814464 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1365-2982 (Electronic) IS - 1350-1925 (Print) IS - 1350-1925 (Linking) VI - 38 IP - 3 DP - 2026 Mar TI - Adolescent Normative Intervals for Body Surface Gastric Mapping: Spectral Analysis. PG - e70282 LID - 10.1111/nmo.70282 [doi] LID - e70282 AB - BACKGROUND: Body surface gastric mapping (BSGM) non-invasively assesses gastric myoelectrical activity along with real-time symptom reporting. In adults, the development of normative intervals has underpinned new explanatory phenotypes, aiding clinical decision-making. This study established normative reference intervals for adolescent BSGM metrics. METHODS: Healthy adolescents aged 12-17 years with a BMI /= 0.22. Median ff-AR was 2.12; reference interval >/= 1.0. CONCLUSIONS AND INFERENCES: This study presents normative reference intervals for BSGM spectral metrics in adolescent populations, informing the interpretation of tests in research and clinical practice. CI - (c) 2026 The Author(s). Neurogastroenterology & Motility published by John Wiley & Sons Ltd. FAU - Humphrey, Gayl AU - Humphrey G AUID- ORCID: 0000-0002-2837-5707 AD - Department of Surgery, The University of Auckland, Auckland, New Zealand. AD - Alimetry, Auckland, New Zealand. FAU - Schamberg, Gabriel AU - Schamberg G AUID- ORCID: 0000-0002-4188-9614 AD - Department of Surgery, The University of Auckland, Auckland, New Zealand. AD - Alimetry, Auckland, New Zealand. FAU - Xu, Binghong AU - Xu B AD - School of Medicine, Western Sydney University, Sydney, Australia. FAU - Dachs, Nicky AU - Dachs N AUID- ORCID: 0009-0009-3964-8086 AD - Alimetry, Auckland, New Zealand. FAU - Foong, Daphne AU - Foong D AUID- ORCID: 0000-0002-9224-1199 AD - Alimetry, Auckland, New Zealand. AD - School of Medicine, Western Sydney University, Sydney, Australia. FAU - Varghese, Chris AU - Varghese C AD - Department of Surgery, The University of Auckland, Auckland, New Zealand. AD - Division of Surgery, Mayo Clinic, Rochester, Minnesota, USA. FAU - Andrews, Christopher N AU - Andrews CN AD - Alimetry, Auckland, New Zealand. AD - Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. FAU - Mousa, Hayat AU - Mousa H AD - Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. AD - Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. FAU - Gharibans, Armen AU - Gharibans A AD - Department of Surgery, The University of Auckland, Auckland, New Zealand. AD - Alimetry, Auckland, New Zealand. AD - Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. FAU - O'Grady, Gregory AU - O'Grady G AD - Department of Surgery, The University of Auckland, Auckland, New Zealand. AD - Alimetry, Auckland, New Zealand. LA - eng GR - Health Research Council of New Zealand/ GR - Children's Hospital of Philadelphia/ PT - Journal Article PL - England TA - Neurogastroenterol Motil JT - Neurogastroenterology and motility JID - 9432572 SB - IM MH - Humans MH - Female MH - Male MH - Adolescent MH - Reference Values MH - Child MH - *Stomach/physiology MH - *Body Surface Potential Mapping/methods/standards MH - Postprandial Period/physiology MH - Body Mass Index PMC - PMC12979704 OTO - NOTNLM OT - adolescent OT - body surface gastric mapping (BSGM) OT - diagnostics OT - pediatric OT - phenotypes OT - reference intervals COIS- G.O. and A.G. hold grants and intellectual property in gastrointestinal electrophysiology. G.S., N.D., D.F., G.O., A.G., G.H., C.V., and C.N.A. are members of Alimetry. G.O. is a Director at The Insides Company. The remaining authors declare no conflicts of interest. EDAT- 2026/03/12 07:04 MHDA- 2026/03/12 13:56 PMCR- 2026/03/12 CRDT- 2026/03/12 01:09 PHST- 2026/02/13 00:00 [revised] PHST- 2025/12/08 00:00 [received] PHST- 2026/02/25 00:00 [accepted] PHST- 2026/03/12 13:56 [medline] PHST- 2026/03/12 07:04 [pubmed] PHST- 2026/03/12 01:09 [entrez] PHST- 2026/03/12 00:00 [pmc-release] AID - NMO70282 [pii] AID - 10.1111/nmo.70282 [doi] PST - ppublish SO - Neurogastroenterol Motil. 2026 Mar;38(3):e70282. doi: 10.1111/nmo.70282. PMID- 41814431 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260915 IS - 2046-4053 (Electronic) IS - 2046-4053 (Linking) VI - 15 IP - 1 DP - 2026 Mar 11 TI - The impact of sports participation on psychological health and social outcomes in children and adolescents: a systematic review and update to the "Mental Health through Sport" conceptual model. LID - 10.1186/s13643-026-03104-1 [doi] LID - 121 AB - BACKGROUND: Sport is a distinct, structured form of physical activity that can support psychological health and social development in children and adolescents. Compared to other forms of physical activity, the unique attributes of sport, including its combination of physical, cognitive, and social opportunities and challenges within structured goal-directed contexts, may confer additional psychological and social benefits. This systematic review synthesizes evidence on the psychological and social outcomes of sport participation in children and adolescents, and proposes an updated, developmentally informed conceptual model explaining the mechanisms through which sport supports mental health. METHODS: A systematic search was conducted across five electronic databases on 18 October 2024, with no date limits applied. Eligible studies were peer-reviewed, published in English, and focused on the relationship between sport participation and psychological and/or social outcomes in 5-17-year olds. Sport was defined as a structured form of physical activity performed individually or in teams, with established rules and a specific objective. Risk of bias was assessed using validated tools tailored to study design. RESULTS: From 17,017 records, 189 studies were included, spanning cross-sectional, longitudinal, and experimental designs. Sport participation was consistently associated with better mental health-including higher self-esteem, life satisfaction, and reduced depressive and anxiety symptoms-and enhanced social outcomes, such as improved interpersonal skills, prosocial behavior, and belonging. Team sports showed stronger and more consistent benefits than individual sports. The experimental evidence highlighted potential causal effects on emotional regulation, resilience, and prosocial behavior. Risk of bias was generally low among randomized trials, although most relied on self-report data and lacked pre-registration. Observational and quasi-experimental studies were methodologically sound but were affected by potential confounding and social desirability bias. CONCLUSIONS: This review provides compelling evidence that organized sport participation supports psychological and social development in children and adolescents. Sport was consistently associated with higher self-esteem, greater life satisfaction, and lower symptoms of depression and anxiety, with team sports showing stronger and more consistent benefits than individual sports. Social outcomes-including enhanced belonging, prosocial behavior, and interpersonal skills-were also evident, underscoring the unique contribution of sport as a social context for development. The refined conceptual model proposed here identifies self-perceptions, peer belonging, and social support as central mechanisms, offering a developmentally informed framework for leveraging sport to promote youth mental health. These findings highlight sport, especially inclusive and well-structured team sports, as a powerful setting for fostering psychological well-being and positive social outcomes, warranting prioritization in youth development policies and programs. CI - (c) 2026. The Author(s). FAU - Wade, Levi AU - Wade L AUID- ORCID: 0000-0002-4007-5336 AD - Global Sport and Movement Collaborative, University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia. AD - Hunter Medical Research Institute, New Lambton, NSW, 2308, Australia. FAU - Eime, Rochelle AU - Eime R AUID- ORCID: 0000-0002-8614-2813 AD - Health, Innovation, and Transformation Centre, Federation University Australia, University Drive, Mount Helen, Victoria, 3350, Australia. FAU - Pankowiak, Aurelie AU - Pankowiak A AUID- ORCID: 0000-0003-0178-513X AD - Institute for Health and Sport, Victoria University, Ballarat Road, Footscray, VIC, 3011, Australia. FAU - Vella, Stewart AU - Vella S AUID- ORCID: 0000-0003-0537-9366 AD - Movember Institute of Men's Health, Richmond, VIC, Australia. AD - School of Psychology, University of Wollongong, Wollongong, NSW, 2500, Australia. FAU - Robinson, Katie AU - Robinson K AUID- ORCID: 0000-0002-8347-4783 AD - Global Sport and Movement Collaborative, University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia. AD - Hunter Medical Research Institute, New Lambton, NSW, 2308, Australia. FAU - Kennedy, Sarah AU - Kennedy S AUID- ORCID: 0000-0001-9804-616X AD - Global Sport and Movement Collaborative, University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia. AD - School of Health Sciences, Western Sydney University, (Darug Country), Kingswood, NSW, 2747, Australia. AD - Translational Health Research Institute, Western Sydney University, (Dharawal Country), Campbelltown, NSW, 2560, Australia. FAU - Parkes, Rebekah AU - Parkes R AUID- ORCID: 0000-0002-3018-0810 AD - Global Sport and Movement Collaborative, University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia. FAU - Eather, Narelle AU - Eather N AUID- ORCID: 0000-0002-6320-4540 AD - Global Sport and Movement Collaborative, University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia. narelle.eather@newcastle.edu.au. AD - Hunter Medical Research Institute, New Lambton, NSW, 2308, Australia. narelle.eather@newcastle.edu.au. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260311 PL - England TA - Syst Rev JT - Systematic reviews JID - 101580575 SB - IM MH - *Mental Health MH - *Youth Sports/psychology MH - Self Concept MH - Humans MH - Child, Preschool MH - Child MH - Adolescent MH - Emotional Regulation MH - Resilience, Psychological MH - *Social Behavior MH - Personal Satisfaction MH - Team Sports MH - *Psychological Well-Being MH - Child Development MH - Adolescent Development PMC - PMC13064252 OTO - NOTNLM OT - Mental health OT - Moderators OT - Organized sport OT - Youth COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/12 07:04 MHDA- 2026/04/09 06:33 PMCR- 2026/03/11 CRDT- 2026/03/12 01:06 PHST- 2025/07/24 00:00 [received] PHST- 2026/02/03 00:00 [accepted] PHST- 2026/04/09 06:33 [medline] PHST- 2026/03/12 07:04 [pubmed] PHST- 2026/03/12 01:06 [entrez] PHST- 2026/03/11 00:00 [pmc-release] AID - 10.1186/s13643-026-03104-1 [pii] AID - 3104 [pii] AID - 10.1186/s13643-026-03104-1 [doi] PST - epublish SO - Syst Rev. 2026 Mar 11;15(1):121. doi: 10.1186/s13643-026-03104-1. PMID- 41807417 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 2052-4463 (Electronic) IS - 2052-4463 (Linking) VI - 13 IP - 1 DP - 2026 Mar 11 TI - A hand biomechanics dataset of kinematics, kinetics, electromyography, and imaging in healthy adults. LID - 10.1038/s41597-026-06939-4 [doi] LID - 646 AB - Developing musculoskeletal hand models requires a variety of experimental biomechanics data. However, collecting robust biomechanics hand data is a time intensive process leading to a lack of widely available datasets. To address this issue the biomechanics hand modeling database (BHaM) was made as a collection of experimental data to aid the development, testing, and validation of musculoskeletal models and simulations. BHaM includes two datasets: (1) a population dataset (n = 726 adults) describing hand strength (pinch and grip), self-reported hand function (Michigan Hand Questionnaire), and anthropometric measurements (from photographs), and (2) a biomechanics dataset (n = 30 adults) describing kinematics (marker-based motion capture), kinetics (isometric and isokinetic data), and electromyography (surface and fine wire) during 19 tasks across the elbow, wrist, and hand. A subset of the biomechanics dataset (n = 15 adults) also includes magnetic resonance imaging of the shoulder through wrist. Participants for both datasets were recruited to represent a diverse population of healthy adults, ranging from 18 to 91 years. CI - (c) 2026. The Author(s). FAU - Diaz, Maximillian T AU - Diaz MT AD - J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. FAU - Benoit, Alexis R AU - Benoit AR AD - J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. FAU - Kearney, Kalyn M AU - Kearney KM AD - J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. FAU - Kelly, Troy F Jr AU - Kelly TF Jr AD - J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. FAU - Lindbeck, Erica M AU - Lindbeck EM AD - Department of Electrical & Computer Engineering, University of Florida, Gainesville, FL, USA. FAU - Tappan, Isaly AU - Tappan I AD - Department of Electrical & Computer Engineering, University of Florida, Gainesville, FL, USA. FAU - Bowers, William S AU - Bowers WS AD - J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. FAU - Durai, Lavanya AU - Durai L AD - J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. FAU - Nunag, Justin B AU - Nunag JB AD - J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. FAU - Officer, Michael B AU - Officer MB AD - J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. FAU - Harley, Joel B AU - Harley JB AD - Department of Electrical & Computer Engineering, University of Florida, Gainesville, FL, USA. FAU - Nichols, Jennifer A AU - Nichols JA AD - J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. jnichols@bme.ufl.edu. LA - eng PT - Dataset PT - Journal Article DEP - 20260311 PL - England TA - Sci Data JT - Scientific data JID - 101640192 SB - IM UOF - bioRxiv. 2025 Aug 25:2025.08.21.671503. doi: 10.1101/2025.08.21.671503. PMID: 40909532 MH - Humans MH - Electromyography MH - Adult MH - Biomechanical Phenomena MH - *Hand/physiology/diagnostic imaging MH - Middle Aged MH - Aged MH - Young Adult MH - Adolescent MH - Aged, 80 and over MH - Female MH - Motion Capture MH - Magnetic Resonance Imaging MH - Hand Strength MH - Kinetics MH - Male PMC - PMC13111597 COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/03/11 06:56 MHDA- 2026/04/27 00:30 PMCR- 2026/03/11 CRDT- 2026/03/11 00:17 PHST- 2025/08/26 00:00 [received] PHST- 2026/02/19 00:00 [accepted] PHST- 2026/04/27 00:30 [medline] PHST- 2026/03/11 06:56 [pubmed] PHST- 2026/03/11 00:17 [entrez] PHST- 2026/03/11 00:00 [pmc-release] AID - 10.1038/s41597-026-06939-4 [pii] AID - 6939 [pii] AID - 10.1038/s41597-026-06939-4 [doi] PST - epublish SO - Sci Data. 2026 Mar 11;13(1):646. doi: 10.1038/s41597-026-06939-4. PMID- 41807093 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20261016 IS - 2047-6310 (Electronic) IS - 2047-6302 (Print) IS - 2047-6302 (Linking) VI - 21 IP - 3 DP - 2026 Mar TI - Validity of the PortionSize App for Assessing Children's Dietary Intake: Results From a Pilot Study Conducted in Controlled and Free-Living Settings. PG - e70102 LID - 10.1111/ijpo.70102 [doi] AB - BACKGROUND: PortionSize is a mobile app that allows users to assess dietary intake and provide feedback in real-time. OBJECTIVE: To assess the validity of the PortionSize app for estimating children's dietary intake when assessed by the children themselves (phase 1) and relative agreement of the app when assessed by their parents (phase 2). METHODS: This pilot study recruited 31 child/parent dyads. Each dyad was trained on the PortionSize app to assess dietary intake. In phase 1, children (7-12 years) assessed dietary intake in a controlled setting, and their assessments were compared with weighed meals. In phase 2, parents assessed their child's dietary intake in a free-living setting, and the criterion measure was the digital photography of foods (DPF) method. RESULTS: Children's energy intake assessments using PortionSize were equivalent to weighed meals (p < 0.05, effect size: 0.22), while energy intake estimates by parents using PortionSize were not equivalent to the DPF method (p > 0.05, effect size: 0.26). The mean percent error between the measurements was 9.1% in phase 1 and 16.5% in phase 2. CONCLUSIONS: The findings suggest PortionSize may be accurate in controlled settings when used by children. In a free-living setting when used by parents, results indicated PortionSize needs improvements in methods for estimating portion size and food identification. The study findings from phase 2 reflect feasibility and relative agreement rather than validation against true intake. This pilot study focuses on initial validity, relative agreement, and user satisfaction, indicating potential for future clinical and community-based pediatric dietary and weight management applications. TRIAL REGISTRATION: NCT05587816 (https://clinicaltrials.gov/study/NCT05587816?term=PortionSize%20app&rank=1). CI - (c) 2026 World Obesity Federation. FAU - Saha, Sanjoy AU - Saha S AUID- ORCID: 0000-0003-0253-8181 AD - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA. AD - Tennessee State University, Nashville, Tennessee, USA. FAU - Diktas, Hanim E AU - Diktas HE AUID- ORCID: 0000-0002-4603-3719 AD - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA. FAU - Lozano, Chloe P AU - Lozano CP AUID- ORCID: 0000-0003-4278-1602 AD - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA. AD - University of Hawaii, Cancer Center, Honolulu, Hawaii, USA. FAU - Staiano, Amanda E AU - Staiano AE AUID- ORCID: 0000-0001-7846-046X AD - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA. FAU - Broyles, Stephanie T AU - Broyles ST AUID- ORCID: 0000-0003-3168-0056 AD - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA. FAU - Apolzan, John W AU - Apolzan JW AUID- ORCID: 0000-0001-8492-7820 AD - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA. FAU - Martin, Corby K AU - Martin CK AUID- ORCID: 0000-0002-8125-4015 AD - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA. LA - eng SI - ClinicalTrials.gov/NCT05587816 GR - 2022-09708/National Institute of Food and Agriculture/ GR - F32 HD116537/HD/NICHD NIH HHS/United States GR - P30 DK072476/DK/NIDDK NIH HHS/United States GR - U54 GM104940/GM/NIGMS NIH HHS/United States GR - NH/NIH HHS/United States GR - P50 MD017338/MD/NIMHD NIH HHS/United States GR - Blue Cross and Blue Shield of Louisiana Foundation/ GR - Eunice Kennedy Shriver National Institute of Child Health and Human Development/ GR - R01 DK124558/DK/NIDDK NIH HHS/United States PT - Clinical Study PT - Journal Article PT - Validation Study PL - England TA - Pediatr Obes JT - Pediatric obesity JID - 101572033 SB - IM MH - Child MH - Female MH - Humans MH - Male MH - *Energy Intake MH - Feeding Behavior MH - *Mobile Applications MH - Nutrition Assessment MH - Parents MH - Pilot Projects MH - *Portion Size MH - Reproducibility of Results PMC - PMC13077788 MID - NIHMS2162283 OTO - NOTNLM OT - MyPlate OT - energy intake OT - food groups OT - food intake OT - food photography OT - paediatrics OT - portion size COIS- CONFLICT OF INTEREST STATEMENT Louisiana State University and Pennington Biomedical Research Center own the intellectual property associated with the PortionSize app. Authors CKM and JWA, who are employed by these institutions, are the inventors of the technology. EDAT- 2026/03/11 01:11 MHDA- 2026/03/11 19:00 PMCR- 2026/04/14 CRDT- 2026/03/10 21:54 PHST- 2026/03/01 00:00 [revised] PHST- 2025/05/01 00:00 [received] PHST- 2026/03/03 00:00 [accepted] PHST- 2026/03/11 19:00 [medline] PHST- 2026/03/11 01:11 [pubmed] PHST- 2026/03/10 21:54 [entrez] PHST- 2026/04/14 00:00 [pmc-release] AID - 10.1111/ijpo.70102 [doi] PST - ppublish SO - Pediatr Obes. 2026 Mar;21(3):e70102. doi: 10.1111/ijpo.70102. PMID- 41806387 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260710 IS - 1465-735X (Electronic) IS - 0146-8693 (Print) IS - 0146-8693 (Linking) VI - 51 IP - 5 DP - 2026 May 1 TI - Predictive utility and cut point of the Physical Activity Questionnaire-Children for differentiating youth meeting moderate to vigorous physical activity recommendations using accelerometry. PG - 405-411 LID - 10.1093/jpepsy/jsaf116 [doi] AB - OBJECTIVE: Moderate-to-vigorous physical activity (MVPA) is associated with a host of health benefits. As researchers continue to develop an understanding of what keeps young people from meeting physical activity recommendations, there is a need to develop efficient and cost-effective measures that can accurately distinguish youth who meet guidelines from those who do not. Therefore, the current study aims to evaluate the utility of the Physical Activity Questionnaire for Children (PAQ-C) in predicting accelerometer-derived estimates of MVPA. METHOD: The final sample included 184 youth between the ages of 8 and 12 years, who completed self-report measures and wore an accelerometer for two weeks. Binary logistic regression was performed to evaluate the relationship between PAQ-C composite score and MVPA recommendation status. Receiver operating characteristic analysis was performed to identify an optimal cut value for the PAQ-C. RESULTS: Age and gender demonstrated small, but significant associations with meeting MVPA recommendation status. Specifically, females and older participants were less likely to meet MVPA recommendations. PAQ-C was also identified as a significant predictor of youth meeting MVPA recommendation status. The area under the curve was found to be .76. A cut value of 3.34 was found to optimize both specificity (.70) and sensitivity (.76). Participants at or above this value can be classified as having met MVPA recommendations. CONCLUSIONS: The PAQ-C was found to be a useful measure for predicting youth meeting MVPA recommendations. Researchers can use these findings to determine if participants are meeting MVPA recommendations of 60 or more minutes of MVPA per day by evaluating if participants meet or exceed the identified PAQ-C cut point. Future studies should continue to establish the predicative utility of the PAQ-C for youth experiencing chronic health conditions, such as obesity. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Hefner, Tristen AU - Hefner T AUID- ORCID: 0000-0002-0324-6036 AD - Clinical Psychology Program, Texas Tech University, Lubbock, TX, United States. FAU - Halbreich, Eli AU - Halbreich E AUID- ORCID: 0000-0003-4942-9804 AD - Clinical Psychology Program, Texas Tech University, Lubbock, TX, United States. FAU - Van Allen, Jason AU - Van Allen J AUID- ORCID: 0000-0002-9228-3815 AD - Clinical Psychology Program, Texas Tech University, Lubbock, TX, United States. LA - eng GR - R03HD095218/Eunice Kennedy Striver National Institute of Child Health and Human Development of the National Institutes of Health/ GR - Eunice Kennedy Striver National Institute of Child Health and Human Development/ GR - R03HD095218/NH/NIH HHS/United States PT - Journal Article PL - United States TA - J Pediatr Psychol JT - Journal of pediatric psychology JID - 7801773 SB - IM MH - Humans MH - Child MH - Female MH - *Exercise/physiology MH - *Accelerometry MH - Male MH - Surveys and Questionnaires/standards PMC - PMC13221184 OTO - NOTNLM OT - health behavior OT - measure development and validation OT - school-age children OT - statistical approach COIS- None of the authors has any competing interests or financial interests to disclose. EDAT- 2026/03/11 01:11 MHDA- 2026/05/30 00:33 PMCR- 2027/03/10 CRDT- 2026/03/10 18:44 PHST- 2025/05/14 00:00 [received] PHST- 2025/12/05 00:00 [revised] PHST- 2025/12/19 00:00 [accepted] PHST- 2026/05/30 00:33 [medline] PHST- 2026/03/11 01:11 [pubmed] PHST- 2026/03/10 18:44 [entrez] PHST- 2027/03/10 00:00 [pmc-release] AID - 8513049 [pii] AID - jsaf116 [pii] AID - 10.1093/jpepsy/jsaf116 [doi] PST - ppublish SO - J Pediatr Psychol. 2026 May 1;51(5):405-411. doi: 10.1093/jpepsy/jsaf116. PMID- 41799549 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1712-171X (Print) IS - 1712-1728 (Electronic) IS - 1712-171X (Linking) VI - 60 IP - 1 DP - 2026 Feb TI - Pilot validation of the new Canadian Caries Risk Assessment Tool for preschoolers. PG - 9-18 AB - BACKGROUND: Caries risk assessment (CRA) is an important step in preventive and therapeutic management of caries in children. This study assessed the sensitivity and specificity of a new Canadian Caries Risk Assessment Tool (<6 years) for preschoolers to predict caries development. METHODS: In this prospective cohort study, CRA was performed at baseline and 12 months among 190 children aged <6 years from 3 clinics in Manitoba, Canada. CRA included information on child's fluoride exposure, teeth cleaning, diet, socio-economic status, and oral examinations. Sensitivity and specificity were calculated, and logistic regression for new caries at follow-up was performed. RESULTS: The sensitivity and specificity for baseline CRA rating and development of new caries at follow-up were 87.2% and 42.7%, respectively. Presence of visible caries and/or past evidence of dental treatment for caries at baseline was the strongest independent indicator of new caries by follow-up (OR = 6.49; CI = 3.28, 12.85; p < 0.001). Children with high caries risk (score >/=3) were more likely to develop new caries by follow-up (OR = 4.58; 95% CI = 2.07, 10.11). DISCUSSION: The combined sensitivity and specificity score is comparable to findings from other studies examining CRA. Results support the increased weighting of the score for the presence of visible caries and/or evidence of dental treatment for caries at baseline. Results from this study provide evidence for the CRA tool's predictability. CONCLUSION: The Canadian Caries Risk Assessment Tool for preschoolers has high sensitivity to identify children with high caries risk, and modest specificity to identify children with low caries risk. However, future population-based studies with primary care providers are recommended. CI - Copyright (c) 2026 CDHA | ACHD. FAU - Schroth, Robert J AU - Schroth RJ AD - Department of Preventive Dental Science, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. AD - Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada. FAU - Siray, Adam AU - Siray A AD - Department of Preventive Dental Science, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. FAU - Lee, Victor Hk AU - Lee VH AD - Department of Preventive Dental Science, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. AD - Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada. FAU - Olatosi, Olubukola O AU - Olatosi OO AD - Department of Preventive Dental Science, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. AD - Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada. AD - Department of Oral Biology, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. FAU - Mittermuller, Betty-Anne AU - Mittermuller BA AD - Department of Preventive Dental Science, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. AD - Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada. FAU - Finch, Amanda AU - Finch A AD - Department of Preventive Dental Science, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. FAU - Hu, Ralph AU - Hu R AD - Department of Preventive Dental Science, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. AD - Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada. FAU - Dufour, Lisette AU - Dufour L AD - Health Canada, Ottawa, ON, Canada. FAU - Brondani, Mario AU - Brondani M AD - Department of Oral Health Science, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada. FAU - Bertone, Mary AU - Bertone M AD - School of Dental Hygiene, Dr. Gerald Niznick College of Dentistry, University of Manitoba, Winnipeg, MB, Canada. FAU - Alai-Towfigh, Hamideh AU - Alai-Towfigh H AD - Department of Preventive Dental Science, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20260201 PL - Canada TA - Can J Dent Hyg JT - Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD JID - 101234082 RN - Q80VPU408O (Fluorides) SB - IM MH - Humans MH - *Dental Caries/epidemiology/prevention & control MH - Risk Assessment/methods MH - Child, Preschool MH - Prospective Studies MH - Female MH - Sensitivity and Specificity MH - Male MH - Pilot Projects MH - Manitoba/epidemiology MH - Infant MH - Follow-Up Studies MH - Social Class MH - Canada MH - Fluorides/therapeutic use MH - Diet MH - Fluoride Treatment PMC - PMC12962308 OTO - NOTNLM OT - caries risk assessment OT - early childhood caries OT - primary care OT - prospective cohort OT - risk factors OT - sensitivity OT - specificity COIS- The authors declare that there are no conflicts of interest. EDAT- 2026/03/09 17:37 MHDA- 2026/03/09 17:38 PMCR- 2026/03/01 CRDT- 2026/03/09 06:19 PHST- 2024/09/10 00:00 [received] PHST- 2025/02/05 00:00 [revised] PHST- 2025/03/30 00:00 [accepted] PHST- 2026/03/09 17:38 [medline] PHST- 2026/03/09 17:37 [pubmed] PHST- 2026/03/09 06:19 [entrez] PHST- 2026/03/01 00:00 [pmc-release] PST - epublish SO - Can J Dent Hyg. 2026 Feb 1;60(1):9-18. eCollection 2026 Feb. PMID- 41799455 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Lifestyle, health behavior, and oral health differences among dentistry, nutrition, and fine arts university students. PG - 1764709 LID - 10.3389/fpubh.2026.1764709 [doi] LID - 1764709 AB - BACKGROUND/OBJECTIVES: University students' lifestyle habits influence their general and oral health in the medium and long term. This study compared physical activity, dietary habits, tobacco and alcohol consumption, and oral hygiene practices among students of Dentistry, Nutrition, and Fine Arts, aiming to identify differences that may guide future preventive interventions. METHODS: A descriptive cross-sectional study was conducted between June and July 2025 at the ADEMA University School (Palma de Mallorca, Spain). The final sample included 165 students (115 Dentistry, 32 Nutrition, and 18 Fine Arts) aged 18-30 years. A validated self-administered questionnaire, adapted from World Health Organization instruments and the ENALIA study, was used to collect sociodemographic variables, physical activity level, screen time, dietary habits, tobacco and alcohol use, and oral hygiene practices. Data were analyzed using descriptive statistics; chi(2) and ANOVA tests were applied according to variable type, with statistical significance set at p < 0.05. The study was approved by the Balearic Islands Research Ethics Committee (IB 5691/24 PI). RESULTS: Nutrition students exhibited the healthiest profiles: 60% reported >/=2-3 h/week of exercise and higher daily fruit and vegetable intake. Dentistry students showed the best self-perceived oral health and the greatest brushing frequency. Fine Arts students exhibited higher sedentary behavior and poorer dietary and oral hygiene habits. Significant differences among degree programs were found in physical activity, diet, and oral health variables (p < 0.05). CONCLUSIONS: Relevant differences in lifestyle and health behaviors were observed according to academic degree. University education appears to influence the adoption of healthy habits; therefore, health promotion programs integrating oral health as an essential component of overall well-being are recommended. CI - Copyright (c) 2026 Coll Campayo, Servera Fuster and Lopez-Safont. FAU - Coll Campayo, Irene AU - Coll Campayo I AD - Faculty of Dentistry, University ADEMA School, Palma, Spain. AD - ADEMA-Health Group, University Institute for Research in Health Sciences (IUNICS), Palma, Spain. FAU - Servera Fuster, Maria AU - Servera Fuster M AD - Faculty of Dentistry, University ADEMA School, Palma, Spain. FAU - Lopez-Safont, Nora AU - Lopez-Safont N AD - Faculty of Dentistry, University ADEMA School, Palma, Spain. AD - ADEMA-Health Group, University Institute for Research in Health Sciences (IUNICS), Palma, Spain. AD - Biology Department, University of the Balearic Islands, Palma, Spain. LA - eng PT - Journal Article DEP - 20260220 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Young Adult MH - *Oral Health/statistics & numerical data MH - Male MH - Adolescent MH - *Health Behavior MH - *Life Style MH - Universities MH - Adult MH - *Students/statistics & numerical data/psychology MH - Spain MH - Exercise MH - Oral Hygiene/statistics & numerical data MH - Surveys and Questionnaires MH - Feeding Behavior PMC - PMC12963299 OTO - NOTNLM OT - dietary habits OT - health behaviors OT - health promotion OT - lifestyle OT - oral health OT - physical activity OT - university students COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/09 17:36 MHDA- 2026/03/09 17:37 PMCR- 2026/02/20 CRDT- 2026/03/09 06:18 PHST- 2025/12/10 00:00 [received] PHST- 2026/01/12 00:00 [revised] PHST- 2026/01/26 00:00 [accepted] PHST- 2026/03/09 17:37 [medline] PHST- 2026/03/09 17:36 [pubmed] PHST- 2026/03/09 06:18 [entrez] PHST- 2026/02/20 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1764709 [doi] PST - epublish SO - Front Public Health. 2026 Feb 20;14:1764709. doi: 10.3389/fpubh.2026.1764709. eCollection 2026. PMID- 41798194 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Short stature-related factors and nomogram-based risk prediction in children aged 7-12: evidence from Chaozhou, China. PG - 1598683 LID - 10.3389/fendo.2026.1598683 [doi] LID - 1598683 AB - OBJECTIVE: Childhood height development is a crucial indicator of public health, with the prevalence of short stature serving as an important metric. This study aimed to investigate the height development status, prevalence of short stature, and associated risk factors among 7-12-year-old children in Chaozhou City, China, providing valuable reference data for local prevention and intervention strategies to address short stature. METHODS: A cross-sectional survey on the height of 7-12-year-old children was conducted in Chaozhou City, Guangdong Province, China. Standardized measurement tools were used to collect height data for epidemiological analysis. To explore risk factors for short stature, a questionnaire survey was administered to a random sample of the surveyed population. Univariate and multivariate logistic regression analyses were conducted to identify factors associated with the risk of short stature and to construct a predictive model. RESULTS: A total of 7,799 children participated in the height survey. Girls had significantly higher mean heights than boys at ages 8, 11, and 12 (all P < 0.001). The overall prevalence of short stature was 3.7%. Although girls had a higher prevalence than boys (4.0% vs. 3.4%), the difference was not statistically significant (P = 0.167). Multivariate logistic regression identified independent risk factors for short stature, including paternal height < 160 cm, maternal height <150 cm, birth weight < 2.5 kg, preterm birth, exercising < 3 times per week, sleep duration < 8 hours per day, and irregular diet. A preference for meat and dairy products was independently associated with a reduced risk of short stature. The nomogram model developed based on these factors demonstrated good predictive performance, with an area under the curve of 0.858 (95%CI 0.815-0.900). CONCLUSIONS: The overall prevalence of short stature in 7-12-year-old children in Chaozhou was slightly higher than the national average. This study analyzed the risk factors for short stature in children, and the risk prediction model developed from these factors demonstrated good predictive accuracy for short stature prevalence. However, external validation in independent cohorts is necessary to confirm the robustness of the model. CI - Copyright (c) 2026 Zhang, Lin, Xu and Cai. FAU - Zhang, Qun AU - Zhang Q AD - Department of Endocrinology, Chaozhou Central Hospital, Chaozhou, China. FAU - Lin, Huarong AU - Lin H AD - Department of Endocrinology, Chaozhou Central Hospital, Chaozhou, China. FAU - Xu, Wencan AU - Xu W AD - The First Affiliated Hospital of Shantou University Medical College, Shantou, China. FAU - Cai, Yifeng AU - Cai Y AD - Department of Critical Care Medicine, Chaozhou Central Hospital, Chaozhou, China. LA - eng PT - Journal Article DEP - 20260220 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - Male MH - Female MH - China/epidemiology MH - Child MH - *Body Height/physiology MH - *Nomograms MH - Risk Factors MH - Cross-Sectional Studies MH - Prevalence MH - *Growth Disorders/epidemiology MH - Surveys and Questionnaires PMC - PMC12962942 OTO - NOTNLM OT - Chaozhou City OT - height development OT - risk factors OT - risk prediction model OT - short stature COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/09 17:36 MHDA- 2026/03/09 17:37 PMCR- 2026/02/20 CRDT- 2026/03/09 06:08 PHST- 2025/03/23 00:00 [received] PHST- 2026/01/10 00:00 [revised] PHST- 2026/01/13 00:00 [accepted] PHST- 2026/03/09 17:37 [medline] PHST- 2026/03/09 17:36 [pubmed] PHST- 2026/03/09 06:08 [entrez] PHST- 2026/02/20 00:00 [pmc-release] AID - 10.3389/fendo.2026.1598683 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Feb 20;17:1598683. doi: 10.3389/fendo.2026.1598683. eCollection 2026. PMID- 41796965 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20261016 IS - 1938-3207 (Electronic) IS - 0002-9165 (Print) IS - 0002-9165 (Linking) VI - 123 IP - 5 DP - 2026 May TI - Monitoring growth and body composition in children with 3-dimensional optical imaging: a pilot observational study. PG - 101256 LID - S0002-9165(26)00065-1 [pii] LID - 10.1016/j.ajcnut.2026.101256 [doi] AB - BACKGROUND: Nutritional disturbances among United States children and adolescents have risen sharply in recent decades. Current guidelines emphasize assessing body composition to track changes in fat mass (FM) and fat-free mass (FFM) after interventions. Three-dimensional optical (3DO) imaging has been validated in cross-sectional pediatric samples, although its accuracy in detecting longitudinal change has not been studied. OBJECTIVES: This study evaluated the ability of 3DO imaging to monitor body composition over time in children and adolescents. METHODS: A subsample of 26 ethnically diverse healthy children and adolescents from the Shape Up! Kids study completed whole-body dual-energy X-ray absorptiometry (DXA) and 3DO scans at baseline and again >/=1 y later. 3DO meshes were registered to a standardized template for vertex correspondence, transformed into principal components with an established shape model, and used to estimate whole-body and regional body composition measures using published equations. Body composition changes from 3DO scans were compared with DXA using linear regression and root mean square error (RMSE) to quantify error. Duplicate baseline scans provided least significant change (LSC) estimates to assess whether observed 3DO imaging changes reflected true changes in body composition. RESULTS: At baseline, mean +/- SD age was 10.2 +/- 3.2 y, with a mean +/- SD body mass index z-score of 0.56 +/- 1.29. On average, there were 1.6 y (range: 12-18 mo) between baseline and follow-up. Agreement between 3DO imaging and DXA (R(2)) for changes in total FM, FFM, and appendicular lean mass was 0.82, 0.81, and 0.77, respectively, with RMSEs of 2.29 kg, 2.79 kg, and 0.78 kg, respectively. Of the sample, 75% to 80% of significant changes in FM and FFM based on DXA LSCs were also categorized as significant by 3DO imaging. CONCLUSIONS: 3DO imaging is capable of monitoring body composition changes over time in children and adolescents. The accuracy, safety, and accessibility of this approach support its feasibility for risk screening in this population. This trial was registered at clinicaltrials.gov as NCT03706612. CI - Published by Elsevier Inc. FAU - Bennett, Jonathan P AU - Bennett JP AD - Department of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, United States. Electronic address: jbennett@cc.hawaii.edu. FAU - Wong, Michael C AU - Wong MC AD - Department of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, United States; Abbott Nutrition, Columbus, OH, United States. FAU - Tian, Isaac Y AU - Tian IY AD - Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA, United States. FAU - Bowen, Aimee AU - Bowen A AD - Department of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, United States. FAU - Liu, Yong E AU - Liu YE AD - Department of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, United States. FAU - Kelly, Nisa N AU - Kelly NN AD - Department of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, United States. FAU - Ramirez, Sophia AU - Ramirez S AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Chow, Dominic AU - Chow D AD - John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, United States. FAU - Pujades, Sergi AU - Pujades S AD - Institute for Research in Digital Science and Technology (INRIA), Universite Grenoble Alpes, CNRS, Grenoble INP, LJK, Grenoble, France. FAU - Garber, Andrea K AU - Garber AK AD - Department of Pediatrics, University of California San Francisco, San Francisco, CA, United States. FAU - Maskarinec, Gertraud AU - Maskarinec G AD - Department of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, United States. FAU - Heymsfield, Steven B AU - Heymsfield SB AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Shepherd, John A AU - Shepherd JA AD - Department of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, United States. LA - eng SI - ClinicalTrials.gov/NCT03706612 GR - R01 DK111698/DK/NIDDK NIH HHS/United States GR - R01 HD082166/HD/NICHD NIH HHS/United States GR - U54 MD007601/MD/NIMHD NIH HHS/United States PT - Journal Article PT - Observational Study DEP - 20260307 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Humans MH - Child MH - *Body Composition MH - Female MH - Pilot Projects MH - Male MH - Adolescent MH - Absorptiometry, Photon MH - *Imaging, Three-Dimensional/methods MH - *Optical Imaging/methods MH - Longitudinal Studies MH - Body Mass Index MH - Cross-Sectional Studies PMC - PMC13660996 MID - NIHMS2210570 OTO - NOTNLM OT - 3-dimensional optical imaging OT - body composition OT - longitudinal study OT - metabolic disease OT - obesity OT - pediatrics COIS- Conflict of interest JAS reports financial support was provided by National Institutes of Health. SBH reports his role on the Medical Advisory Boards of Tanita Corporation, Regeneron, Amgen, and Medifast and financial support was provided by National Institutes of Health. AKG's time is in part supported by the National Institutes of Health (R01HD082166). DC's time is in part supported by the National Institutes of Health (U54MD007601 and OTA-21-015A). All other authors report no conflicts of interest. EDAT- 2026/03/09 07:41 MHDA- 2026/05/04 00:31 PMCR- 2026/10/13 CRDT- 2026/03/09 00:48 PHST- 2025/09/23 00:00 [received] PHST- 2026/01/12 00:00 [revised] PHST- 2026/02/25 00:00 [accepted] PHST- 2026/05/04 00:31 [medline] PHST- 2026/03/09 07:41 [pubmed] PHST- 2026/03/09 00:48 [entrez] PHST- 2026/10/13 00:00 [pmc-release] AID - S0002-9165(26)00065-1 [pii] AID - 10.1016/j.ajcnut.2026.101256 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 May;123(5):101256. doi: 10.1016/j.ajcnut.2026.101256. Epub 2026 Mar 7. PMID- 41796691 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2026 Mar 9 TI - Assessment of construct validity and reliability of the Canadian Ultra-Processed Product Screener. PG - e69 LID - 10.1017/S1368980026102304 [doi] LID - e69 AB - OBJECTIVE: The Canadian Ultra-Processed Product Screener (CUPS) was developed to rapidly assess ultra-processed food (UPF) and drink product intake among Canadian adults. The CUPS is an online self-administered screener that includes twenty-eight questions and assesses the intake of a variety of UPF available in Canada, both in French and English. This study aimed to assess the construct validity and reliability of the CUPS among a sample of adults in Canada. DESIGN: Cross-sectional study (between July and November 2023). SETTINGS: Participants completed the online CUPS screener in three versions (1-d (twice), 7-d and 30-d CUPS) and three 24-h dietary recalls (24HR) (the reference measure) over the course of 26-28 d. PARTICIPANTS: 354 Canadians aged 18-60 years. RESULTS: The CUPS had an acceptable construct validity, with moderate correlation coefficients between the CUPS score and UPF consumption level measured using multiple 24HR (from 0.33 to 0.44). Reproducibility was also acceptable (intraclass correlation = 0.61) and internal consistency ranged from good to excellent (Cronbach's alpha = 0.72 for the 1-d and 0.86 for the 30-d CUPS). CUPS scores were also associated with higher intake of added sugars, saturated fats and Na. CONCLUSIONS: This study provides evidence supporting the construct validity and reliability of the CUPS among Canadian adults. The CUPS is useful for identifying low and high consumers of UPF and could serve as a proxy measure for one key dimension of diet quality, which is the type of food processing. FAU - Hamel, Virginie AU - Hamel V AUID- ORCID: 0000-0001-8467-3138 AD - Department de Nutrition, https://ror.org/0161xgx34Universite de Montreal, Montreal, Canada. FAU - Desmarais, Sara AU - Desmarais S AUID- ORCID: 0009-0006-7233-0078 AD - Department de Nutrition, https://ror.org/0161xgx34Universite de Montreal, Montreal, Canada. FAU - Kirkpatrick, Sharon AU - Kirkpatrick S AUID- ORCID: 0000-0001-9896-5975 AD - School of Public Health and Health Systems, University of Waterloo, Waterloo, Canada. FAU - Y Polsky, Jane AU - Y Polsky J AUID- ORCID: 0009-0009-0926-8234 AD - Department of Health Analysis Division, Statistics Canada, Ottawa, Canada. FAU - Byker Shanks, Carmen AU - Byker Shanks C AD - Gretchen Swanson Center for Nutrition, Omaha, NE, USA. FAU - da Costa Louzada, Maria Laura AU - da Costa Louzada ML AD - Department of Nutricao, Universidade de Sao Paulo Faculdade de Saude Publica, Sao Paulo, Brazil. FAU - Vanderlee, Lana AU - Vanderlee L AUID- ORCID: 0000-0001-5384-1821 AD - Ecole de Nutrition, Universite Laval, Quebec, Canada. FAU - Hamond, David AU - Hamond D AD - School of Public Health and Health Systems, University of Waterloo, Waterloo, Canada. FAU - Gariguet, Didier AU - Gariguet D AD - Department of Health Analysis Division, Statistics Canada, Ottawa, Canada. FAU - Moubarac, Jean-Claude AU - Moubarac JC AD - Department de Nutrition, https://ror.org/0161xgx34Universite de Montreal, Montreal, Canada. LA - eng PT - Journal Article PT - Validation Study DEP - 20260309 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Reproducibility of Results MH - Canada MH - Adult MH - Cross-Sectional Studies MH - Female MH - Middle Aged MH - Food, Processed MH - Adolescent MH - Young Adult MH - Male MH - *Fast Foods/statistics & numerical data MH - *Diet Surveys/methods MH - *Diet/statistics & numerical data MH - Surveys and Questionnaires/standards PMC - PMC13087981 OTO - NOTNLM OT - Construct validity OT - Dietary assessment OT - Reliability OT - Screener OT - Ultra-processed foods COIS- There are no conflicts of interest. EDAT- 2026/03/09 07:41 MHDA- 2026/04/01 07:04 PMCR- 2026/03/09 CRDT- 2026/03/09 00:44 PHST- 2026/04/01 07:04 [medline] PHST- 2026/03/09 07:41 [pubmed] PHST- 2026/03/09 00:44 [entrez] PHST- 2026/03/09 00:00 [pmc-release] AID - S1368980026102304 [pii] AID - 10.1017/S1368980026102304 [doi] PST - epublish SO - Public Health Nutr. 2026 Mar 9;29(1):e69. doi: 10.1017/S1368980026102304. PMID- 41793297 OWN - NLM STAT- MEDLINE DCOM- 20261020 LR - 20261020 IS - 1461-7277 (Electronic) IS - 1359-1053 (Linking) VI - 31 IP - 13 DP - 2026 Nov TI - Psychometric properties and predictive validity of Brazilian reward-based eating drive scale. PG - 5296-5310 LID - 10.1177/13591053261420602 [doi] AB - This study aimed to adapt and validate the Reward-Based Eating Drive Scale (RED-13) for Brazilian Portuguese and assess its psychometric properties and predictive validity. The adaptation process followed established cross-cultural guidelines, including translation, synthesis, back-translation, expert committee review, and pilot testing. Content validity was evaluated using the Content Validity Index. A total of 452 adults aged 18-59 years, recruited online, participated in the psychometric assessment. Confirmatory factor analysis supported the scale's three-dimensional structure (RMSEA < 0.0001, SRMR = 0.041, TLI = 1.000, CFI = 1.000). Internal consistency was high (alpha = 0.921, omega = 0.922). RED-13 BR scores showed moderate correlations with food cravings and weak correlations with body mass index (rho = 0.266, p < 0.001). Receiver operating characteristic analysis indicated predictive ability for pre-obesity and obesity. These findings suggest that the RED-13 BR is a valid and reliable instrument for assessing reward-based eating behavior in Brazilian adults. FAU - da Silva, Taina Lopes AU - da Silva TL AUID- ORCID: 0000-0002-6238-2273 AD - Pontifical Catholic University of Rio Grande Do Sul, PUCRS, Porto Alegre, Brazil. FAU - Vainik, Uku AU - Vainik U AD - University of Tartu, Estonia. AD - McGill University, Montreal, ON, Canada. FAU - Mason, Ashley AU - Mason A AD - Center for Health and Community, San Francisco, CA, USA. AD - UCSF Osher Center for Integrative Health, San Francisco, CA, USA. FAU - Urbanetto, Janete de Souza AU - Urbanetto JS AD - Pontifical Catholic University of Rio Grande Do Sul, PUCRS, Porto Alegre, Brazil. FAU - Feoli, Ana Maria Pandolfo AU - Feoli AMP AD - Pontifical Catholic University of Rio Grande Do Sul, PUCRS, Porto Alegre, Brazil. LA - eng PT - Journal Article PT - Validation Study DEP - 20260307 PL - England TA - J Health Psychol JT - Journal of health psychology JID - 9703616 SB - IM MH - Humans MH - Adult MH - Brazil MH - *Psychometrics/instrumentation MH - Female MH - *Reward MH - Middle Aged MH - *Feeding Behavior/psychology MH - Adolescent MH - Young Adult MH - Reproducibility of Results MH - Male MH - Surveys and Questionnaires/standards MH - Obesity/psychology OTO - NOTNLM OT - eating behavior OT - obesity OT - reward-driven eating OT - reward-related eating OT - validation study COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/03/07 16:13 MHDA- 2026/10/20 17:34 CRDT- 2026/03/07 07:43 PHST- 2026/10/20 17:34 [medline] PHST- 2026/03/07 16:13 [pubmed] PHST- 2026/03/07 07:43 [entrez] AID - 10.1177/13591053261420602 [doi] PST - ppublish SO - J Health Psychol. 2026 Nov;31(13):5296-5310. doi: 10.1177/13591053261420602. Epub 2026 Mar 7. PMID- 41792911 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 1552-681X (Electronic) IS - 0272-989X (Print) IS - 0272-989X (Linking) VI - 46 IP - 5 DP - 2026 Jul TI - Adapting Sexual Behavior Survey Data to Parameterize an Agent-Based Model of Human Papillomavirus (HPV) Transmission. PG - 591-600 LID - 10.1177/0272989X261425681 [doi] AB - PurposeSexual transmission of human papillomavirus (HPV) infection is important for capturing the indirect effects of interventions in mathematical models, but limited data create challenges for reflecting sexual behavior patterns over the lifespan of individuals and across heterogenous populations. We used nationally representative data from the United States to parameterize, calibrate, and validate a heterosexual transmission model of HPV.MethodsBased on sexual behavior data from the National Survey of Family Growth (2011-2019), we categorized respondents into 4 sexual activity categories, using their percentile of cumulative lifetime partners compared with others within their same sex and age group. We modeled probabilistic partnership acquisition and dissolution by age, sex, and sexual activity category. Partnership data were incorporated into an existing agent-based model of HPV transmission in the United States. We calibrated 1) per-partnership HPV transmission and 2) reduced risk of type-specific reinfection from natural immunity to fit age- and type-specific HPV prevalence using the National Health and Nutrition Examination Survey (NHANES 2002-2008). We validated the final model by comparing model-based projections of HPV prevalence against empirical data in the US population before and after widespread HPV vaccination.ResultsAfter calibrating to fit overall HPV prevalence, model validation exercises indicated that the distribution of prevaccine HPV prevalence across sexual activity categories closely matched NHANES estimates. Simulating vaccination rates over 10 y, the model replicated postvaccine NHANES data for prevalence of HPV16.ConclusionCapturing HPV transmission dynamics requires an understanding of sexual behavior across populations and over time. Defining sexual activity categories based on cumulative lifetime partners can capture patterns of HPV risk over a lifespan to reflect the dynamics of HPV transmission and vaccination.HighlightsUsing data from a large national survey, we developed sexual behavior inputs for an agent-based model of HPV transmission.We define 4 heterogenous risk groups using cumulative lifetime sexual behavior for males and females and find we can recreate validation data on both lifetime sexual patterns and age-specific HPV prevalence.Our calibrated model also reproduces early patterns of HPV reduction following HPV vaccine introduction.Modelers seeking to understand the long-term effects of the HPV vaccine should carefully consider the heterogeneity of sexual behavior across groups as well as changes in behavior over the lifespan. FAU - Spencer, Jennifer C AU - Spencer JC AUID- ORCID: 0000-0001-9508-1525 AD - Department of Population Health, Dell Medical School, UT Austin, Austin, TX, USA. AD - Department of Internal Medicine, Dell Medical School, UT Austin, Austin, TX, USA. FAU - Burger, Emily A AU - Burger EA AUID- ORCID: 0000-0002-6657-5849 AD - Department of Health Management and Health Economics, University of Oslo, Oslo, Blindern, Norway. AD - Center for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA, USA. FAU - Portnoy, Allison AU - Portnoy A AUID- ORCID: 0000-0002-8467-1324 AD - Department of Global Health, Boston University School of Public Health, Boston, MA, USA. FAU - Campos, Nicole G AU - Campos NG AUID- ORCID: 0000-0002-0840-4339 AD - Center for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA, USA. FAU - Regan, Mary Caroline AU - Regan MC AD - Center for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA, USA. FAU - Sy, Stephen AU - Sy S AD - Center for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA, USA. FAU - Kim, Jane J AU - Kim JJ AUID- ORCID: 0000-0002-9892-9170 AD - Center for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA, USA. LA - eng GR - K01 MD017633/MD/NIMHD NIH HHS/United States GR - U01 CA253912/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20260306 PL - United States TA - Med Decis Making JT - Medical decision making : an international journal of the Society for Medical Decision Making JID - 8109073 RN - 0 (Papillomavirus Vaccines) SB - IM MH - Humans MH - *Papillomavirus Infections/transmission/epidemiology/prevention & control MH - Female MH - *Sexual Behavior/statistics & numerical data MH - Male MH - United States/epidemiology MH - Adult MH - *Human Papillomavirus Viruses MH - Middle Aged MH - Adolescent MH - Papillomavirus Vaccines MH - Surveys and Questionnaires MH - Prevalence MH - Nutrition Surveys MH - Young Adult PMC - PMC12970602 MID - NIHMS2145887 OTO - NOTNLM OT - calibration OT - human papillomavirus OT - sexually transmitted infection OT - simulation model OT - vaccination COIS- The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by grants from the National Institute of Minority Health and Health Disparities (1K01MD017633-03; PI: Spencer), National Institutes of Health/National Cancer Institute (U01CA253912), and PATH and Bill and Melinda Gates Foundation on behalf of the Single-Dose HPV Vaccine Evaluation Consortium. The funding agreement ensured the author's independence in designing the study, interpreting the data, writing, and publishing the report. EDAT- 2026/03/07 06:38 MHDA- 2026/06/12 00:38 PMCR- 2026/06/07 CRDT- 2026/03/07 00:23 PHST- 2026/06/12 00:38 [medline] PHST- 2026/03/07 06:38 [pubmed] PHST- 2026/03/07 00:23 [entrez] PHST- 2026/06/07 00:00 [pmc-release] AID - 10.1177_0272989X261425681 [pii] AID - 10.1177/0272989X261425681 [doi] PST - ppublish SO - Med Decis Making. 2026 Jul;46(5):591-600. doi: 10.1177/0272989X261425681. Epub 2026 Mar 6. PMID- 41792847 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260627 LR - 20260813 IS - 2055-0928 (Electronic) IS - 2055-0928 (Linking) VI - 12 IP - 1 DP - 2026 Mar 7 TI - Assessment of association between problematic internet use and overweight and obesity among in school adolescents in Addis Ababa, Ethiopia. LID - 10.1186/s40795-026-01295-3 [doi] LID - 69 AB - BACKGROUND: Overweight and obesity among adolescents is one of the most serious public health concerns worldwide in the 21st century. Problematic internet use (PIU) is associated with physical inactivity, sedentary behavior, disrupted sleep, and poor dietary habits, which can contribute to overweight/obesity and adversely affect mental wellbeing among adolescents. Several epidemiological studies, have explored the association between problematic internet use and overweight/obesity and reported inconsistent findings. The majority of the studies in this regard were from developed nations and there are limited studies from developing countries including Ethiopia. OBJECTIVES: The study is aimed to assess the association between problematic internet use and overweight and obesity among secondary school adolescents in Addis Ababa, Ethiopia. METHODS: A school-based cross-sectional study was conducted among adolescents aged 13-19 in public and private secondary schools in Addis Ababa from March to June 2025. A total of 501 adolescents were selected using a three-stage random sampling technique. Problematic internet use was assessed using the validated Amharic version of the Internet Addiction Test (IAT-20). Body Mass Index (BMI) for age Z-score was compared to WHO 2007 growth reference standards using WHO Anthro plus version 3.2.2 software. Data were entered and cleaned using epi data version 3.1 and all statistical tests were done using SPSS 20 software. RESULTS: The prevalence of overweight, obesity, and combined overweight/obesity was 16.6%, 4.2%, and 20.8%, respectively. The overall prevalence of PIU was 56.3%. After adjusting for confounders, adolescents with mild (AOR = 8.84; 95%CI: 2.99-26.10), moderate (AOR = 8.65; 95%CI: 2.81-26.62), and severe (AOR = 3.97; 95%CI: 1.36-11.57) PIU had significantly higher odds of overweight/obesity compared to those with normal internet use. Skipping breakfast, low physical activity, and high sedentary time were also significant independent risk factors. CONCLUSION AND RECOMMENDATION: The study reveals a high prevalence of PIU and a strong, graded association between PIU severity and overweight/obesity among in-school adolescents in Addis Ababa. Parents should encourage their children for managing their children's internet use and promoting healthier lifestyles at home. FAU - Abera, Melkamu AU - Abera M AD - Department of Nutrition and Dietetics, School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia. gariabera@gmail.com. FAU - Haidar, Jemal AU - Haidar J AD - Department of Nutrition and Dietetics, School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia. FAU - Shikur, Bilal AU - Shikur B AD - Department of Nutrition and Dietetics, School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia. LA - eng PT - Journal Article DEP - 20260307 PL - England TA - BMC Nutr JT - BMC nutrition JID - 101672434 PMC - PMC13081461 OTO - NOTNLM OT - Adolescents OT - Internet OT - Internet use OT - Obesity OT - Overweight OT - Problematic internet use COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/03/07 01:37 MHDA- 2026/03/07 01:38 PMCR- 2026/03/07 CRDT- 2026/03/06 23:47 PHST- 2025/08/05 00:00 [received] PHST- 2026/02/28 00:00 [accepted] PHST- 2026/03/07 01:38 [medline] PHST- 2026/03/07 01:37 [pubmed] PHST- 2026/03/06 23:47 [entrez] PHST- 2026/03/07 00:00 [pmc-release] AID - 10.1186/s40795-026-01295-3 [pii] AID - 1295 [pii] AID - 10.1186/s40795-026-01295-3 [doi] PST - epublish SO - BMC Nutr. 2026 Mar 7;12(1):69. doi: 10.1186/s40795-026-01295-3. PMID- 41792680 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Mar 7 TI - Nutritional status and associated factors in Ethiopian children with congenital heart disease: a systematic review and meta - analysis. LID - 10.1186/s12887-026-06707-8 [doi] LID - 315 AB - BACKGROUND: In low-resource settings like Ethiopia, Congenital Heart Disease is frequently complicated by a high yet poorly defined burden of malnutrition. To address this gap, this systematic review and meta-analysis aimed to rigorously quantify the pooled prevalence of undernutrition and identify determinants driving this condition among affected Ethiopian children. METHODS: Adhering to PRISMA guidelines and a prospective registration, this systematic review and meta-analysis included non-randomized studies reporting on malnutrition in Ethiopian children with congenital heart disease, which were identified through a comprehensive search of PubMed, Medline, HINARI, ScienceDirect, Scopus and Google Scholar up to November 15, 2025. The risk of bias was appraised using the Newcastle-Ottawa Scale, and data synthesis was performed in Stata version 17 using a random-effects meta-analysis to calculate pooled prevalence and Odds Ratios with 95% Confidence Intervals. Heterogeneity was quantified using the I2 statistic, while the robustness of the findings was evaluated through subgroup and leave-one-out sensitivity analyses. To address publication bias identified via funnel plot asymmetry, a non-parametric trim-and-fill analysis was applied to generate a more robust adjusted pooled prevalence, with forest plots utilized to visualize all individual and aggregate results. RESULTS: A total of 1,849 children across seven studies were included in the analysis. The overall pooled prevalence of undernutrition among Ethiopian children with CHD was estimated at 44.48% (95% CI: 38.44% - 50.52%, I2 = 95.3%). Significant associated factors for undernutrition were the presence of heart failure (OR = 4.12, 95% CI: 3.74-4.50, I2 = 4.2%), pulmonary hypertension (OR = 2.53, 95% CI: 1.93-3.13, I2 = 89.1%) & comorbidities (OR = 1.39, 95% CI: 1.25-1.54, I2 = 93%). CONCLUSION: Undernutrition impacts approximately 45% of Ethiopian children with congenital heart disease, primarily driven by clinical challenges like heart failure and pulmonary hypertension, which necessitates a shift toward integrated, multidisciplinary pediatric care. However, the reliability of this prevalence rate is undermined by significant statistical heterogeneity and the non-randomized nature of existing research, creating a high risk of bias and limited generalizability. To address these critical limitations, it is recommended that both clinical and research frameworks adopt standardized malnutrition diagnostic criteria and more rigorous study designs to ensure that future interventions are based on consistent, high-quality data rather than fragmented estimates. TRIAL REGISTRATION: CRD420251230006. FAU - Yirdaw, Berhanu Wale AU - Yirdaw BW AUID- ORCID: 0000-0003-0489-9634 AD - Department of Pediatrics and Child Health Nursing, Teda Health Science College, P.O.BOX: 790, Gondar, Amhara, Ethiopia. berhanuwale7@gmail.com. FAU - Agmas, Maritu Ayalew AU - Agmas MA AD - Department of Midwifery, Teda Health Science College, Gondar, Amhara, Ethiopia. FAU - Mekonen, Fasika Alemu AU - Mekonen FA AD - Department of Midwifery, Teda Health Science College, Gondar, Amhara, Ethiopia. FAU - Worku, Seferash Yohannes AU - Worku SY AD - Department of Midwifery, Teda Health Science College, Gondar, Amhara, Ethiopia. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260307 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Ethiopia/epidemiology MH - *Heart Defects, Congenital/complications/epidemiology MH - *Nutritional Status MH - Prevalence MH - *Malnutrition/epidemiology MH - Child MH - Risk Factors PMC - PMC13081370 OTO - NOTNLM OT - Associated Factors OT - Children OT - Congenital Heart Disease OT - Ethiopia OT - Nutritional Status COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/07 01:38 MHDA- 2026/06/27 12:39 PMCR- 2026/03/07 CRDT- 2026/03/06 23:38 PHST- 2025/12/12 00:00 [received] PHST- 2026/03/02 00:00 [accepted] PHST- 2026/06/27 12:39 [medline] PHST- 2026/03/07 01:38 [pubmed] PHST- 2026/03/06 23:38 [entrez] PHST- 2026/03/07 00:00 [pmc-release] AID - 10.1186/s12887-026-06707-8 [pii] AID - 6707 [pii] AID - 10.1186/s12887-026-06707-8 [doi] PST - epublish SO - BMC Pediatr. 2026 Mar 7;26(1):315. doi: 10.1186/s12887-026-06707-8. PMID- 41792652 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Mar 6 TI - Diagnostic accuracy of mid-upper arm circumference-for-age Z-score (MUACZ) for detecting malnutrition in children with cerebral palsy: a cross-sectional study. LID - 10.1186/s12887-026-06639-3 [doi] LID - 306 AB - BACKGROUND: Malnutrition is common in children with cerebral palsy (CP) due to feeding difficulties, altered body composition, and functional limitations, making an accurate nutritional assessment essential. The mid-upper arm circumference-for-age Z-score (MUACZ) is a practical screening tool, yet its diagnostic performance across childhood and adolescence remains insufficiently defined. The objective of this study was to assess the prevalence of undernutrition in children suffering from CP as well as the diagnostic performance of MUACZ in comparison with other anthropometric indicators across different age groups. METHODS: This cross-sectional study included 81 children with CP aged 2-18 years. Nutritional status was assessed using BMI-for-age (BAZ), height-for-age (HAZ), and MUACZ. Functional severity was classified using validated systems (GMFCS and EDACS). The diagnostic accuracy of MUACZ was evaluated with ROC analysis, and predictors of undernutrition were identified using multivariate logistic regression. RESULTS: Undernutrition (BAZ or HAZ 98%) and accuracy (>94%), with markedly variable sensitivity (35%-48%). CONCLUSIONS: Machine learning models using simple and low-cost predictors can estimate the probability of LLM with acceptable discrimination. The proposed model may assist primary care clinicians in risk stratification once externally validated. Further work is needed to establish operational thresholds and evaluate real-world clinical utility. CI - (c) The Author(s) 2026. Published by Oxford University Press. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Arlettaz, Maximiliano Ezequiel AU - Arlettaz ME AUID- ORCID: 0000-0002-7507-7059 AD - Universidad Nacional de Entre Rios-Concepcion del Uruguay P.C. 3260, Argentina. FAU - Staurini, Stefano AU - Staurini S AD - Centro de Investigaciones en Nutricion Humana (CenINH)-Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Cordoba P.C. 5000, Argentina. FAU - Ormaechea, Camila AU - Ormaechea C AD - Centro de Investigaciones en Nutricion Humana (CenINH)-Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Cordoba P.C. 5000, Argentina. FAU - Gonzalez, Maria Fernanda AU - Gonzalez MF AD - Universidad Nacional de Entre Rios-Concepcion del Uruguay P.C. 3260, Argentina. FAU - Aballay, Laura R AU - Aballay LR AD - Centro de Investigaciones en Nutricion Humana (CenINH)-Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Cordoba P.C. 5000, Argentina. LA - eng PT - Journal Article PL - England TA - Fam Pract JT - Family practice JID - 8500875 SB - IM MH - Humans MH - Female MH - Male MH - Middle Aged MH - Adult MH - Cross-Sectional Studies MH - Primary Health Care MH - Absorptiometry, Photon MH - *Machine Learning MH - Boosting Machine Learning Algorithms MH - Young Adult MH - Adolescent MH - Body Mass Index MH - Random Forest MH - Early Diagnosis MH - *Sarcopenia/diagnosis MH - Predictive Learning Models MH - Nutrition Surveys MH - Logistic Models MH - Classification Algorithms MH - Prediction Algorithms MH - Decision Trees OAB - Low lean mass (LLM) refers to having reduced muscle tissue, which can lead to serious health problems like weakness, fatigue, and a higher risk of chronic diseases. It is often difficult to detect early because the best tools, like DXA scans, are expensive and not widely available in regular health checkups. In this study, we used data from a large U.S. health survey to test whether machine learning-computer programs that can find patterns in data-can help identify people with LLM using simple information like age, height, weight, gender, and handgrip strength. We evaluated six different machine learning methods. One of them, called XGBoost, showed the most favorable overall balance between correctly identifying people with LLM and avoiding false positives, and had better discriminatory ability than a comparable tree-based model. At the same time, the model tended to underestimate the absolute level of risk, its sensitivity was modest, and the clinical benefit suggested by decision curve analysis was limited. These results suggest that, after further validation in real-world healthcare settings, such models could complement existing tools and help clinicians recognize low muscle mass earlier using only simple, routinely collected measurements. OABL- eng OTO - NOTNLM OT - artificial intelligence OT - body composition OT - lean mass OT - machine learning OT - sarcopenia COIS- Conflicts of interest: The authors declare no competing interests with respect to this publication. EDAT- 2026/03/05 12:49 MHDA- 2026/03/08 01:38 CRDT- 2026/03/05 08:43 PHST- 2026/03/08 01:38 [medline] PHST- 2026/03/05 12:49 [pubmed] PHST- 2026/03/05 08:43 [entrez] AID - 8507058 [pii] AID - 10.1093/fampra/cmag002 [doi] PST - ppublish SO - Fam Pract. 2026 Feb 7;43(2):cmag002. doi: 10.1093/fampra/cmag002. PMID- 41783905 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260305 LR - 20260920 IS - 2353-5571 (Electronic) IS - 2353-4184 (Print) IS - 2353-5571 (Linking) VI - 14 IP - 1 DP - 2025 TI - Impact of personality traits and motivation on adolescent sports participation. PG - 78-91 LID - 10.5114/hpr/212560 [doi] AB - BACKGROUND: Participation in physical-sporting activities is associated with positive physical, emotional, and social development during adolescence, a critical period characterized by significant biological, cognitive, and social changes. These developmental processes interact dynamically with individual differences in psychological traits and motivational factors, which strongly affect adolescents' sustained engagement and overall health outcomes through sport. PARTICIPANTS AND PROCEDURE: A sample of adolescents was assessed using validated questionnaires measuring intrinsic and extrinsic motivation, personality traits, and levels of physical activity. Statistical analyses were conducted to examine associations between these variables and to identify gender differences. RESULTS: Intrinsic motivation was found to be strongly associated with sports engagement, showing a higher correlation than extrinsic motivation. Personality traits such as extraversion were positively associated with higher physical activity levels; gender differences emerged in neuroticism and conscientiousness, with females scoring higher in these traits. Adolescents exhibiting high intrinsic motivation showed lower neuroticism and greater openness to experience, outlining a characteristic psychosocial profile linked to sustained sports participation. CONCLUSIONS: These findings highlight the importance of integrating both motivation and personality considerations when developing interventions aimed at promoting active and healthy lifestyles in adolescence. Understanding these psychological factors can facilitate the creation of tailored strategies by educators, families, and sports professionals to enhance youth engagement and well-being. CI - Copyright (c) Institute of Psychology, University of Gdansk. FAU - Diaz-Rodriguez, Carlos AU - Diaz-Rodriguez C AUID- ORCID: 0000-0002-5110-2352 AD - University of Oviedo, Oviedo, Spain. FAU - Martinez-Lopez, Fernando AU - Martinez-Lopez F AUID- ORCID: 0000-0001-6490-0997 AD - Rey Juan Carlos University (URJC), Madrid, Spain. FAU - Catalina, Alvaro Dietta AU - Catalina AD AUID- ORCID: 0009-0001-6343-0468 AD - Comillas Pontifical University, Madrid, Spain. LA - eng PT - Journal Article DEP - 20251216 PL - Poland TA - Health Psychol Rep JT - Health psychology report JID - 101677269 PMC - PMC12955768 OTO - NOTNLM OT - adolescence OT - gender OT - intrinsic motivation OT - personality OT - physical-sporting activity EDAT- 2026/03/05 07:09 MHDA- 2026/03/05 07:10 PMCR- 2025/12/16 CRDT- 2026/03/05 04:58 PHST- 2025/08/18 00:00 [received] PHST- 2025/09/19 00:00 [revised] PHST- 2025/10/14 00:00 [accepted] PHST- 2026/03/05 07:10 [medline] PHST- 2026/03/05 07:09 [pubmed] PHST- 2026/03/05 04:58 [entrez] PHST- 2025/12/16 00:00 [pmc-release] AID - 212560 [pii] AID - 10.5114/hpr/212560 [doi] PST - epublish SO - Health Psychol Rep. 2025 Dec 16;14(1):78-91. doi: 10.5114/hpr/212560. eCollection 2025. PMID- 41783825 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260926 IS - 1661-8564 (Electronic) IS - 1661-8556 (Print) IS - 1661-8556 (Linking) VI - 71 DP - 2026 TI - The First Swiss National Nutrition Survey in Children and Adolescents, menuCH-Kids: Study Design, Participants, and Data Quality. PG - 1609314 LID - 10.3389/ijph.2026.1609314 [doi] LID - 1609314 AB - OBJECTIVES: menuCH-Kids was launched to generate the first Swiss nationwide children's dietary data, assess food contaminant exposure, and inform nutrition policies. This paper describes the methods, data quality, and participants characteristics. METHODS: In 2023-2024, a cross-sectional population-based survey in six Swiss centres collected dietary data via two non-consecutive 24-hour recalls/records and a Food Propensity Questionnaire; lifestyle, health, eating behaviours and sociodemographic information via online questionnaires; anthropometrics, urine, and voluntary blood samples by trained professionals with standardized procedures in 6-17-year-olds. Area-based socioeconomic position (Swiss-SEP) was linked to home addresses. Statistical weights corrected for unequal selection probabilities and non-response. Factors associated with participation were explored using logistic regressions. RESULTS: 1,852 participants attended the visit (participation rate = 11.9%). Data quality was high (<6% missing values, 15.1% dietary under-reporters, and 98% of biosamples processed on time). Non-participants were older, male, non-Swiss, from lower socioeconomic neighbourhoods, and smaller household. Adding socioeconomic position improved participation prediction models. CONCLUSION: menuCH-Kids provides high-quality dietary and health data on Swiss youth. Low participation highlights the need for a weighting strategy including socioeconomic position to compensate biases. CI - Copyright (c) 2026 Vincentini, Riou, Hausermann, Schwitzguebel, Estoppey Younes, Catalano, Brombach, Chaouch, Chatelan, Dratva, Isler, Muller, Rezzi, Righini-Grunder, Rohrmann, Saner, Simonetti, Uhlmann, Vanoni, Zuberbuehler, Siegfried-Troxler, Suggs, van der Horst and Bochud. FAU - Vincentini, Julia AU - Vincentini J AD - Department of Epidemiology and Health Systems, Unisante, University Center for Primary Care and Public Health and University of Lausanne, Lausanne, Switzerland. FAU - Riou, Julien AU - Riou J AD - Department of Epidemiology and Health Systems, Unisante, University Center for Primary Care and Public Health and University of Lausanne, Lausanne, Switzerland. FAU - Hausermann, Tanja AU - Hausermann T AD - School of Health Professions, Bern University of Applied Sciences, Bern, Switzerland. FAU - Schwitzguebel, Joelle AU - Schwitzguebel J AD - Department of Epidemiology and Health Systems, Unisante, University Center for Primary Care and Public Health and University of Lausanne, Lausanne, Switzerland. FAU - Estoppey Younes, Sandrine AU - Estoppey Younes S AD - Department of Epidemiology and Health Systems, Unisante, University Center for Primary Care and Public Health and University of Lausanne, Lausanne, Switzerland. FAU - Catalano, Loan AU - Catalano L AD - School of Health Professions, Bern University of Applied Sciences, Bern, Switzerland. FAU - Brombach, Christine AU - Brombach C AD - Institute of Food technology, Zurich University of Applied Sciences, Wadenswil, Switzerland. FAU - Chaouch, Aziz AU - Chaouch A AD - Department of Epidemiology and Health Systems, Unisante, University Center for Primary Care and Public Health and University of Lausanne, Lausanne, Switzerland. FAU - Chatelan, Angeline AU - Chatelan A AD - Department of Nutrition and Dietetics, Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland, Carouge-Geneva, Switzerland. FAU - Dratva, Julia AU - Dratva J AD - Institute of Public Health, Zurich University of Applied Sciences, Winterthur, Switzerland. FAU - Isler, Franziska AU - Isler F AD - YouGov Schweiz, Zurich, Switzerland. FAU - Muller, Pascal AU - Muller P AD - Adolescent Medicine and Paediatric Psychosomatics, Children's Hospital of Eastern Switzerland, St. Gallen, Switzerland. FAU - Rezzi, Serge AU - Rezzi S AD - Swiss Nutrition and Health Foundation, Lausanne, Switzerland. FAU - Righini-Grunder, Franziska AU - Righini-Grunder F AD - Children's Hospital of Central Switzerland, Lucerne, Switzerland. FAU - Rohrmann, Sabine AU - Rohrmann S AD - Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich, Zurich, Switzerland. FAU - Saner, Christoph AU - Saner C AD - Department of Pediatrics, Inselspital - Bern University Hospital and University of Bern, Bern, Switzerland. FAU - Simonetti, Giacomo D AU - Simonetti GD AD - Paediatric Institute of Southern Switzerland, Regional Hospital of Bellinzona - EOC and University of Lugano, Bellinzona, Switzerland. FAU - Uhlmann, Katja AU - Uhlmann K AD - School of Health Professions, Bern University of Applied Sciences, Bern, Switzerland. FAU - Vanoni, Federica AU - Vanoni F AD - Paediatric Institute of Southern Switzerland, Regional Hospital of Bellinzona - EOC and University of Lugano, Bellinzona, Switzerland. FAU - Zuberbuehler, Christine Anne AU - Zuberbuehler CA AD - Division of Food and Nutrition, Federal Food Safety and Veterinary Office, Bern, Switzerland. FAU - Siegfried-Troxler, Aline AU - Siegfried-Troxler A AD - Division of Food and Nutrition, Federal Food Safety and Veterinary Office, Bern, Switzerland. FAU - Suggs, Suzanne AU - Suggs S AD - Faculty of Communication, Culture and Society, University of Lugano, Lugano, Switzerland. FAU - van der Horst, Klazine AU - van der Horst K AD - School of Health Professions, Bern University of Applied Sciences, Bern, Switzerland. FAU - Bochud, Murielle AU - Bochud M AD - Department of Epidemiology and Health Systems, Unisante, University Center for Primary Care and Public Health and University of Lausanne, Lausanne, Switzerland. LA - eng PT - Journal Article DEP - 20260217 PL - Switzerland TA - Int J Public Health JT - International journal of public health JID - 101304551 SB - IM MH - Humans MH - Male MH - Switzerland MH - Adolescent MH - Child MH - Cross-Sectional Studies MH - *Nutrition Surveys/methods MH - Female MH - *Data Accuracy MH - Socioeconomic Factors MH - Research Design MH - Life Style MH - Diet PMC - PMC12953171 OTO - NOTNLM OT - 24-hours dietary recalls OT - Switzerland OT - children and adolescents OT - nutrition survey OT - participation bias COIS- Author FI was employed by the company YouGov Schweiz. The remaining authors declare that they do not have any conflicts of interest. EDAT- 2026/03/05 07:09 MHDA- 2026/03/07 01:37 PMCR- 2026/02/17 CRDT- 2026/03/05 04:58 PHST- 2025/11/12 00:00 [received] PHST- 2025/12/31 00:00 [revised] PHST- 2026/01/21 00:00 [accepted] PHST- 2026/03/07 01:37 [medline] PHST- 2026/03/05 07:09 [pubmed] PHST- 2026/03/05 04:58 [entrez] PHST- 2026/02/17 00:00 [pmc-release] AID - 1609314 [pii] AID - 10.3389/ijph.2026.1609314 [doi] PST - epublish SO - Int J Public Health. 2026 Feb 17;71:1609314. doi: 10.3389/ijph.2026.1609314. eCollection 2026. PMID- 41782980 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1815-672X (Electronic) IS - 0028-2715 (Print) IS - 0028-2715 (Linking) VI - 63 IP - 292 DP - 2025 Dec TI - Anthropometric Study of the Human Ear Among Patients Visiting People's Dental College and Hospital: An Observational Study. PG - 894-897 LID - 10.31729/jnma.v63i292.9249 [doi] AB - INTRODUCTION: Anthropometric measurements of the external ear provide valuable normative data for applications in clinical practice, reconstructive surgery, forensics, and ergonomics. As ear morphology varies by population, sex, and age, population-specific reference data are essential. This study aimed to determine the normal dimensions of the outer ear among adult patients. METHODS: A cross-sectional study was conducted from 8th to 28th September 2025 among 157 adult patients (82 males and 75 females) visiting the hospital with normal external ears. Standardized auricular measurements, including auricular height, auricular width, lobular height, and lobular width, were obtained bilaterally using a digital vernier caliper following established anthropometric landmarks. Data were analyzed using descriptive statistics to calculate the mean and standard deviation. RESULTS: The mean right and left auricular heights were 63.38 +/- 6.19 mm and 63.13 +/- 6.49 mm, respectively, while auricular widths were 33.81 +/- 6.26 mm (right) and 33.82 +/- 6.23 mm (left). Minimal bilateral asymmetry was observed. Males exhibited greater auricular height and width, whereas females showed marginally larger lobular dimensions. Lobular height demonstrated greater variability than width across both sexes. CONCLUSION: The study revealed strong bilateral symmetry in external ear measurements, with clear sexual dimorphism-males having larger auricular dimensions and females slightly larger lobules. This finding provide baseline data for Nepalese adults and hold relevance in forensic identification, prosthetic design, and reconstructive surgery. Further large-scale, multiethnic studies are recommended to validate and expand upon these findings. CI - (c) The Author(s) 2025. FAU - Bajracharya, Mangesh AU - Bajracharya M AD - Department of Anatomy, People's Dental College and Hospital, Nayabazar, Kathmandu, Nepal. FAU - Maharjan, Shyam Kaji AU - Maharjan SK AD - Department of Prosthodontics, People's Dental College and Hospital, Nayabazar, Kathmandu, Nepal. FAU - Shrestha, Dristi AU - Shrestha D AD - Department of Anatomy, People's Dental College and Hospital, Nayabazar, Kathmandu, Nepal. FAU - Pathak, Chetana AU - Pathak C AD - Department of ENT, People's Dental College and Hospital, Nayabazar, Kathmandu, Nepal. LA - eng PT - Journal Article PT - Observational Study DEP - 20251231 PL - Nepal TA - JNMA J Nepal Med Assoc JT - JNMA; journal of the Nepal Medical Association JID - 0045233 SB - IM MH - Humans MH - Female MH - Male MH - Adult MH - Cross-Sectional Studies MH - *Anthropometry/methods MH - Nepal MH - *Ear, External/anatomy & histology MH - Young Adult MH - Middle Aged MH - Reference Values MH - Adolescent MH - Sex Characteristics MH - Sex Factors PMC - PMC12906748 OTO - NOTNLM OT - anthropometry OT - auricular dimensions OT - sexual dimorphism COIS- None. EDAT- 2026/03/05 07:09 MHDA- 2026/03/07 06:39 PMCR- 2025/12/01 CRDT- 2026/03/05 04:47 PHST- 2025/10/18 00:00 [received] PHST- 2025/10/25 00:00 [revised] PHST- 2025/11/26 00:00 [accepted] PHST- 2026/03/07 06:39 [medline] PHST- 2026/03/05 07:09 [pubmed] PHST- 2026/03/05 04:47 [entrez] PHST- 2025/12/01 00:00 [pmc-release] AID - 10.31729/jnma.v63i292.9249 [doi] PST - ppublish SO - JNMA J Nepal Med Assoc. 2025 Dec;63(292):894-897. doi: 10.31729/jnma.v63i292.9249. Epub 2025 Dec 31. PMID- 41782651 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260305 LR - 20260813 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 3 DP - 2026 Mar TI - Sensor-Equipped Digital Technologies for Monitoring and Detecting Depressive Disorders: A Systematic Review. PG - e71743 LID - 10.1002/hsr2.71743 [doi] LID - e71743 AB - BACKGROUND AND AIMS: Depression is a common and chronic mental health problem, and the diagnosis and management of depression require continuous monitoring. In this review study, sensor-based digital tools for the diagnosis and management of depression were examined. The effectiveness, usability, and limitations of these tools were evaluated and discussed. METHODS: This systematic review was conducted in November 2025 using databases including IEEE, PubMed, Scopus, and Web of Science. The search was performed in accordance with PRISMA guidelines. Peer-reviewed studies that had used digital technologies for the diagnosis, monitoring, or intervention in depression were identified. Eligible articles were included in the study after full-text assessment. RESULTS: In total, 41 studies met the inclusion criteria. Sample sizes in the studies ranged from 5 to 3936 participants. The study populations covered a wide range, from adolescents to older adults. Most investigations addressed various depressive disorders; some also referred to bipolar disorders or psychological distress. Overall, digital tools were categorized into smartphones, wearables, hybrid systems, and innovative platforms. These tools often used sensors such as global positioning systems (GPS), accelerometers, and heart rate monitors. Speech and facial analyzers were also employed. Data collection was carried out through active and passive monitoring of behavior, physiology, and mood. CONCLUSION: Sensor-based digital tools have the capability to monitor and record the complex symptoms of depression. These data can also be used for personalized care. However, robust and standardized validation is required for clinical implementation. Future research should focus on long-term engagement and scalability of these tools while maintaining confidentiality and sensitivity, with an emphasis on specific types of depression. CI - (c) 2026 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Rahimi, Milad AU - Rahimi M AD - Health and Biomedical Informatics Research Center Urmia University of Medical Sciences Urmia Iran. AD - Department of Medical Informatics, School of Allied Medical Sciences Urmia University of Medical Sciences Urmia Iran. FAU - Abrishamifar, Kimia AU - Abrishamifar K AD - Department of Health Information Management, School of Management & Information Sciences Shiraz University of Medical Science Shiraz Iran. FAU - Hazhir, Shadi AU - Hazhir S AD - Department of Health Information Technology and Management, School of Allied Medical Sciences Shahid Beheshti University of Medical Sciences Tehran Iran. FAU - Valizadeh, Hossein AU - Valizadeh H AD - Department of Health Information Management, School of Health Management and Information Sciences Iran University of Medical Sciences Tehran Iran. FAU - Nourani, Aynaz AU - Nourani A AUID- ORCID: 0000-0001-5010-9774 AD - Health and Biomedical Informatics Research Center Urmia University of Medical Sciences Urmia Iran. AD - Department of Medical Informatics, School of Allied Medical Sciences Urmia University of Medical Sciences Urmia Iran. FAU - Rahimi, Bahlol AU - Rahimi B AUID- ORCID: 0000-0003-4927-1664 AD - Health and Biomedical Informatics Research Center Urmia University of Medical Sciences Urmia Iran. AD - Department of Medical Informatics, School of Allied Medical Sciences Urmia University of Medical Sciences Urmia Iran. LA - eng PT - Journal Article PT - Review DEP - 20260302 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC12953198 OTO - NOTNLM OT - depression OT - mental health OT - sensor OT - smartphone OT - wearable COIS- The authors declare no conflicts of interest. EDAT- 2026/03/05 07:09 MHDA- 2026/03/05 07:10 PMCR- 2026/03/02 CRDT- 2026/03/05 04:44 PHST- 2025/04/01 00:00 [received] PHST- 2025/12/10 00:00 [revised] PHST- 2026/01/03 00:00 [accepted] PHST- 2026/03/05 07:10 [medline] PHST- 2026/03/05 07:09 [pubmed] PHST- 2026/03/05 04:44 [entrez] PHST- 2026/03/02 00:00 [pmc-release] AID - HSR271743 [pii] AID - 10.1002/hsr2.71743 [doi] PST - epublish SO - Health Sci Rep. 2026 Mar 2;9(3):e71743. doi: 10.1002/hsr2.71743. eCollection 2026 Mar. PMID- 41782200 OWN - NLM STAT- MEDLINE DCOM- 20261019 LR - 20261020 IS - 1467-1107 (Electronic) IS - 1047-9511 (Linking) VI - 36 IP - 3 DP - 2026 Mar TI - Awareness and practice of physical activity in Omani children with CHDs: a cross-sectional study. PG - 459-462 LID - 10.1017/S1047951125110366 [doi] AB - BACKGROUND: CHDs, affecting 1.1% of newborns, are the most prevalent congenital anomalies. Improved survival rates expose children with CHD to long-term risks such as metabolic and acquired cardiovascular disorders. Despite physical activity's benefits, participation is often limited by real and perceived safety concerns. This study evaluates awareness and practice of physical activity among Omani children with CHD. AIM: To quantify physical activity levels and identify influencing factors in Omani children with CHD. METHODS: This cross-sectional study, conducted at major Omani paediatric cardiology centres, surveyed parents of children aged 5-18 years with CHD attending clinics from January 2019 to January 2023. A validated questionnaire assessed activity levels and influencing factors. Children with recent surgery (<3 months), single ventricle, cardiomyopathies, or without parental consent were excluded. RESULTS: Among 412 children, mean weekly physical activity was 2.18 hours. Parental participation in sports (beta = 0.42, p < 0.001) and cardiologist encouragement (beta = 0.38, p < 0.001) significantly increased activity levels. Children in houses (64% participation) were more active than those in apartments (34%, p = 0.004). Acyanotic CHD was associated with higher participation (66%) than cyanotic CHD (45%). Gender, parental education, and surgical history were not significant predictors. CONCLUSION: Omani children with CHD engage in insufficient physical activity. Parental involvement and cardiologist guidance are critical drivers. We recommend targeted educational programmes and routine exercise counselling to enhance participation. FAU - Al-Awidi, Osama AU - Al-Awidi O AUID- ORCID: 0009-0004-9435-4279 AD - Child Health, SQU, Oman. ROR: https://ror.org/04wq8zb47 AD - Pediatrics, OMSB, Oman. FAU - Al Abri, Issam AU - Al Abri I AD - College of Medicine & Health Sciences, SQU, Oman. FAU - Al-Subhi, Ahmed AU - Al-Subhi A AD - College of Medicine & Health Sciences, SQU, Oman. FAU - Joshi, Narinjan AU - Joshi N AD - Child Health, SQU, Oman. ROR: https://ror.org/04wq8zb47 FAU - Powell, Adam AU - Powell A AD - Pediatric Cardiology, Cincinnati Children's Hospital Medical Center Heart Institute, USA. FAU - Al Sinidi, Khalfan AU - Al Sinidi K AD - Child Health, SQU, Oman. ROR: https://ror.org/04wq8zb47 FAU - Al Balushi, Asim AU - Al Balushi A AUID- ORCID: 0000-0002-2803-2587 AD - Paediatric Cardiology, National Heart Centre, Oman. FAU - Al Riyami, Hilal AU - Al Riyami H AD - Child Health, SQU, Oman. ROR: https://ror.org/04wq8zb47 AD - Pediatrics, SQUH, Muscat, Oman. ROR: https://ror.org/049xx5c95 LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260305 PL - England TA - Cardiol Young JT - Cardiology in the young JID - 9200019 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Male MH - Oman/epidemiology MH - Child MH - Child, Preschool MH - Adolescent MH - *Exercise/physiology MH - *Heart Defects, Congenital/epidemiology/physiopathology MH - *Health Knowledge, Attitudes, Practice MH - Surveys and Questionnaires MH - *Parents/psychology OTO - NOTNLM OT - CHD OT - Oman OT - cardiologist guidance OT - caregiver awareness OT - paediatrics OT - physical activity EDAT- 2026/03/05 07:09 MHDA- 2026/10/19 05:30 CRDT- 2026/03/05 00:12 PHST- 2026/10/19 05:30 [medline] PHST- 2026/03/05 07:09 [pubmed] PHST- 2026/03/05 00:12 [entrez] AID - S1047951125110366 [pii] AID - 10.1017/S1047951125110366 [doi] PST - ppublish SO - Cardiol Young. 2026 Mar;36(3):459-462. doi: 10.1017/S1047951125110366. Epub 2026 Mar 5. PMID- 41781682 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Mar 4 TI - Predictors of exercise participation among Saudi adults attending primary healthcare centers in Riyadh. LID - 10.1038/s41598-026-42374-6 [doi] LID - 11990 AB - Background Regular exercise is crucial for preventing chronic diseases. Saudi Arabia, undergoing rapid socioeconomic transformation, faces escalating rates of lifestyle-related illnesses, underscoring the urgent need to understand exercise participation among its residents. This study aims to identify key sociodemographic and health-related predictors of exercise engagement in this unique context, thereby informing targeted public health strategies. Methods This cross-sectional survey was conducted from March to July 2023 across 48 primary healthcare centers in Riyadh, Saudi Arabia, selected via multi-stage cluster sampling. A total of 14,239 adults (aged >/= 18) completed an electronic, interview-based questionnaire. A rigorously validated and reliable questionnaire collected self-reported data on sociodemographic characteristics, health behaviors and comorbidities. Univariate and multivariate logistic regression were used to identify predictors of exercise participation, with a p-value < 0.05 considered statistically significant in the adjusted model. Results Overall, a substantial 60.7% of participants reported engaging in regular exercise. Male sex was found to be a strong predictor (AOR = 1.14, 95% CI: 1.06-1.22, P = 0.001). Employed individuals were more likely to exercise (AOR = 1.40, 95% CI: 1.30-1.51, P < 0.001) than unemployed Saudi residents. The strongest predictor was health insurance coverage (AOR = 1.61, 95% CI: 1.48-1.75, P < 0.001). Smoking (AOR = 5.42, 95% CI: 4.82-6.08, P < 0.001) and fast-food consumption (AOR = 10.76, 95% CI: 9.77-11.84, P < 0.001) were also associated with higher odds of exercise. Individuals with heart disease showed significantly higher odds of exercising (AOR = 1.85, 95% CI: 1.42-2.41, P < 0.001). Conclusion Our findings underscore the complex interplay of sociodemographic factors, health behaviors, and existing health conditions in shaping exercise participation in Saudi Arabia. The significant influence of male sex, employment, insurance coverage, and the intriguing relationships with smoking, fast-food consumption, and specific health conditions, provide crucial insights. These results highlight key areas for developing tailored public health strategies and interventions to enhance exercise participation in Saudi Arabia. FAU - Al-Khateeb, Badr F AU - Al-Khateeb BF AUID- ORCID: 0000-0001-9824-7148 AD - King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. AD - College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. AD - Ministry of the National Guard-Health Affairs, Riyadh, Saudi Arabia. FAU - Shubair, Mamdouh M AU - Shubair MM AUID- ORCID: 0000-0003-4758-072X AD - Faculty of Human and Health Sciences (FHHS), School of Health Sciences, University of Northern British Columbia (UNBC), 3333 University Way, Prince George, BC, V2N 4Z9, Columbia, Canada. mamdouh.shubair@unbc.ca. FAU - Elmetwally, Mariam A A AU - Elmetwally MAA AD - Department of Psychology and Global One Health Academy, North Carolina State University, Raleigh, NC, USA. FAU - Alharthy, Amani AU - Alharthy A AUID- ORCID: 0000-0003-2668-6058 AD - Department of Health Science, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Zaidan, Amal Mousa AU - Zaidan AM AUID- ORCID: 0000-0003-4838-9281 AD - King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. AD - Ministry of the National Guard-Health Affairs, Riyadh, Saudi Arabia. AD - College of Public Health & Health Informatics, King Saud Bin, Abdulaziz University for Health Science, Riyadh, Saudi Arabia. FAU - Alshahrani, Awad AU - Alshahrani A AUID- ORCID: 0000-0001-8266-6145 AD - King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. AD - College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. AD - Ministry of the National Guard-Health Affairs, Riyadh, Saudi Arabia. FAU - Angawi, Khadijah AU - Angawi K AUID- ORCID: 0000-0002-7625-1813 AD - Faculty of Economics and Administration, Department of Health Services and Hospital Administration, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Aldubikhi, Aljohrah Ibrahim AU - Aldubikhi AI AUID- ORCID: 0000-0001-6795-5029 AD - College of Health Sciences, Saudi Electronic University, Riyadh, Saudi Arabia. FAU - Sannaa, Faisal AU - Sannaa F AD - College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. FAU - Aldahan, Sara Mohammed AU - Aldahan SM AUID- ORCID: 0009-0008-1580-303X AD - Health Education Department, Health Education Specialist, Prince Mohammed Bin Fahad Hospital for Blood Diseases, Eastern Health Cluster, Eastern Province, Al Qatif, Saudi Arabia. FAU - Aldahash, Raed AU - Aldahash R AUID- ORCID: 0000-0001-9612-4072 AD - King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. AD - College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. AD - Ministry of the National Guard-Health Affairs, Riyadh, Saudi Arabia. FAU - Alnaim, Lubna AU - Alnaim L AUID- ORCID: 0009-0002-3786-2379 AD - King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. AD - Ministry of the National Guard-Health Affairs, Riyadh, Saudi Arabia. AD - College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, Al Ahsa, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260304 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Male MH - Saudi Arabia MH - Female MH - *Exercise MH - Adult MH - *Primary Health Care/statistics & numerical data MH - Middle Aged MH - Cross-Sectional Studies MH - *Health Behavior MH - Surveys and Questionnaires MH - Young Adult MH - Socioeconomic Factors MH - Adolescent MH - Aged PMC - PMC13068885 OTO - NOTNLM OT - Exercise participation OT - Health behaviors OT - Predictors OT - Saudi Arabia OT - Sociodemographic COIS- Declarations. Competing Interests: The authors declare no competing interests. Ethics approval and consent to participate: "The ethical approval for the current study was taken from Intuitional Review Board of King Fahad medical city (approval # 22-397E). The study was conducted in accordance with the Declaration of Helsinki. The written informed consent to participate were taken from all participants before the data collection process.". EDAT- 2026/03/05 00:39 MHDA- 2026/06/27 06:45 PMCR- 2026/03/04 CRDT- 2026/03/04 23:25 PHST- 2025/11/04 00:00 [received] PHST- 2026/02/25 00:00 [accepted] PHST- 2026/06/27 06:45 [medline] PHST- 2026/03/05 00:39 [pubmed] PHST- 2026/03/04 23:25 [entrez] PHST- 2026/03/04 00:00 [pmc-release] AID - 10.1038/s41598-026-42374-6 [pii] AID - 42374 [pii] AID - 10.1038/s41598-026-42374-6 [doi] PST - epublish SO - Sci Rep. 2026 Mar 4;16(1):11990. doi: 10.1038/s41598-026-42374-6. PMID- 41780730 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1938-3207 (Electronic) IS - 0002-9165 (Print) IS - 0002-9165 (Linking) VI - 123 IP - 5 DP - 2026 May TI - Ultraprocessed foods consumption and risk of preeclampsia: a secondary analysis of the improving mothers for a better prenatal care trial Barcelona (IMPACT BCN) randomized clinical trial. PG - 101255 LID - S0002-9165(26)00064-X [pii] LID - 10.1016/j.ajcnut.2026.101255 [doi] LID - 101255 AB - BACKGROUND: Preeclampsia is a pregnancy-specific condition affecting 2%-8% of pregnant females and a leading cause of maternal and perinatal morbimortality. High ultraprocessed food (UPF) consumption has been associated with the development of noncommunicable chronic diseases, but evidence on pregnancy outcomes is scarce. OBJECTIVES: To study the association of maternal UPF consumption and the risk of preeclampsia. METHODS: This study is a secondary analysis of the IMPACT BCN, a randomized clinical trial including 1221 pregnant females at high risk for small for gestational age newborns, conducted in Barcelona, Spain. Among these, 812 participants with complete dietary data at 2 timepoints during pregnancy (between weeks 19-23 of gestation and weeks 34-36 of gestation) were included in this analysis and classified into tertiles of change in UPF consumption during pregnancy. Dietary UPF consumption was assessed using NOVA classification with a validated 151-item food frequency questionnaire. Preeclampsia was defined as high blood pressure plus targeted organ involvement. Analyses were performed using logistic regression models adjusted for potential confounding factors. RESULTS: Associations between change of UFP consumption during pregnancy and overall preeclampsia were observed across tertiles [odds ratio (OR)(T3 compared with T1): 2.29; 95% confidence interval (CI): 1.06, 4.97, P-trend 0.026], but not when UPF change was modeled as a continuous variable [OR: 1.04; 95% CI: 0.95, 1.14]. Among UPF subclasses, pre-prepared dishes were significantly associated with preeclampsia risk [OR(T3 compared with T1): 2.36; 95% CI: 1.09, 5.12]. CONCLUSIONS: In a high-risk population, a higher change in dietary intake of UPF consumption from the second to third trimester of pregnancy was associated with a higher risk of preeclampsia. This trial was registered at clinicaltrials.gov as NCT03166332. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Trejo-Dominguez, Alejandra AU - Trejo-Dominguez A AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Institut de Recerca Sant Joan de Deu, Esplugues de Llobregat, Barcelona, Spain. FAU - Benitez, Leticia AU - Benitez L AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. FAU - Crovetto, Francesca AU - Crovetto F AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Institut de Recerca Sant Joan de Deu, Esplugues de Llobregat, Barcelona, Spain; Spanish Network in Maternal, Neonatal, Child and Developmental Health Research, RICORS-SAMID, RD24/0013/0004, Instituto de Salud Carlos III, Madrid, Spain; Departament de Ciencies Cliniques, Facultat de Medicina i Ciencies de la Salut, Universitat de Barcelona, Barcelona, Spain. Electronic address: francesca.crovetto@sjd.es. FAU - Casas, Rosa AU - Casas R AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Madrid, Spain; Institut de Recerca en Nutricio i Seguretat Alimentaria (INSA-UB), University of Barcelona, Barcelona, Spain; Department of Internal Medicine Hospital Clinic, University of Barcelona, Barcelona, Spain. Electronic address: rcasas1@recerca.clinic.cat. FAU - Youssef, Lina AU - Youssef L AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. FAU - Larroya, Marta AU - Larroya M AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Dexeus Mujer (Hospital Universitari Dexeus), Barcelona, Spain. FAU - Ruiz-Leon, Ana Maria AU - Ruiz-Leon AM AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Madrid, Spain; Institut de Recerca en Nutricio i Seguretat Alimentaria (INSA-UB), University of Barcelona, Barcelona, Spain; Department of Internal Medicine Hospital Clinic, University of Barcelona, Barcelona, Spain. FAU - Nakaki, Ayako AU - Nakaki A AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. FAU - Genero, Mariona AU - Genero M AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Institut de Recerca Sant Joan de Deu, Esplugues de Llobregat, Barcelona, Spain; Spanish Network in Maternal, Neonatal, Child and Developmental Health Research, RICORS-SAMID, RD24/0013/0004, Instituto de Salud Carlos III, Madrid, Spain. FAU - Casas, Irene AU - Casas I AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. FAU - Novoa, Rommy H AU - Novoa RH AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain. FAU - Encabo, Noelia AU - Encabo N AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Institut de Recerca Sant Joan de Deu, Esplugues de Llobregat, Barcelona, Spain; Spanish Network in Maternal, Neonatal, Child and Developmental Health Research, RICORS-SAMID, RD24/0013/0004, Instituto de Salud Carlos III, Madrid, Spain. FAU - Rahman, Michael AU - Rahman M AD - Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. FAU - Wang, Xiaosuo AU - Wang X AD - Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. FAU - O'Sullivan, John F AU - O'Sullivan JF AD - Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia; CardioMetabolic Medicine Laboratory, The University of Sydney, Camperdown, New South Wales, Australia; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia; Department of Cardiology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia; Charles Perkins Centre, The University of Sydney, Camperdown, New South Wales, Australia; Department of Medicine, TU Dresden, Helmholtzstr, Dresden, Germany. FAU - Hegarty, Narelle R AU - Hegarty NR AD - ANSTO, Lucas Heights, New South Wales, Australia. FAU - Vieta, Eduard AU - Vieta E AD - Department of Psychiatry and Psychology, Hospital Clinic, Neuroscience Institute, University of Barcelona, IDIBAPS, Center for Biomedical Research on Mental Health (CIBERSAM), Barcelona, Spain. FAU - Gratacos, Eduard AU - Gratacos E AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Institut de Recerca Sant Joan de Deu, Esplugues de Llobregat, Barcelona, Spain; Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centre for Biomedical Research on Rare Diseases (CIBERER), Barcelona, Spain. FAU - Estruch, Ramon AU - Estruch R AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Madrid, Spain; Institut de Recerca en Nutricio i Seguretat Alimentaria (INSA-UB), University of Barcelona, Barcelona, Spain; Department of Internal Medicine Hospital Clinic, University of Barcelona, Barcelona, Spain. FAU - Crispi, Fatima AU - Crispi F AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centre for Biomedical Research on Rare Diseases (CIBERER), Barcelona, Spain. FAU - Castro-Barquero, Sara AU - Castro-Barquero S AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Madrid, Spain; Institut de Recerca en Nutricio i Seguretat Alimentaria (INSA-UB), University of Barcelona, Barcelona, Spain. LA - eng SI - ClinicalTrials.gov/NCT03166332 PT - Journal Article PT - Randomized Controlled Trial DEP - 20260302 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Adult MH - Female MH - Humans MH - Infant, Newborn MH - Pregnancy MH - Young Adult MH - *Diet MH - Food, Processed MH - *Pre-Eclampsia/etiology/epidemiology MH - *Prenatal Care MH - Risk Factors MH - Spain/epidemiology MH - Secondary Data Analysis PMC - PMC13197901 OTO - NOTNLM OT - Mediterranean diet OT - preeclampsia OT - pregnancy OT - prenatal OT - ultraprocessed foods COIS- Conflict of interest RE reports grants from the Fundacion Dieta Mediterranea (Spain), and Cerveza y Salud (Spain), and personal fees for given lectures from Brewers of Europe (Belgium), the Fundacion Cerveza y Salud (Spain), Pernaud-Ricard (Mexico), Instituto Cervantes (Alburquerque, United States), Instituto Cervantes (Milan, Italy), Instituto Cervantes (Tokyo, Japan), Lilly Laboratories (Spain), and the Wine and Culinary International Forum (Spain), as well as nonfinancial support for the organization of a National Congress on Nutrition and feeding trials with products from Grand Fountain and Uriach Laboratories (Spain). EV has received grants and served as consultant, advisor or CME speaker for the following entities: AB-Biotics, Abbott, AbbVie, Adamed, Alcediag, Angelini, Biogen, Beckley-Psytech, Biohaven, Boehringer-Ingelheim, Casen-Recordati, Celon Pharma, Compass, Dainippon Sumitomo Pharma, Esteve, Ethypharm, Ferrer, Gedeon Richter, GH Research, Glaxo-Smith Kline, HMNC, Idorsia, Johnson & Johnson, Lundbeck, Luye Pharma, Medincell, Merck, Mitsubishi Tanabe Pharma, Newron, Novartis, Organon, Orion Corporation, Otsuka, Roche, Rovi, Sage, Sanofi-Aventis, Sunovion, Takeda, Teva, and Viatris, outside the submitted work. The other authors report no conflicts of interest. EDAT- 2026/03/05 00:39 MHDA- 2026/05/04 00:31 PMCR- 2026/03/02 CRDT- 2026/03/04 19:13 PHST- 2025/07/15 00:00 [received] PHST- 2026/02/13 00:00 [revised] PHST- 2026/02/25 00:00 [accepted] PHST- 2026/05/04 00:31 [medline] PHST- 2026/03/05 00:39 [pubmed] PHST- 2026/03/04 19:13 [entrez] PHST- 2026/03/02 00:00 [pmc-release] AID - S0002-9165(26)00064-X [pii] AID - 101255 [pii] AID - 10.1016/j.ajcnut.2026.101255 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 May;123(5):101255. doi: 10.1016/j.ajcnut.2026.101255. Epub 2026 Mar 2. PMID- 41777605 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260304 LR - 20260926 IS - 2673-4842 (Electronic) IS - 2673-4842 (Linking) VI - 7 DP - 2026 TI - A common risk factor strategy for combating childhood oral diseases and malnutrition in Kalpetta, India. PG - 1673066 LID - 10.3389/froh.2026.1673066 [doi] LID - 1673066 AB - AIM/PURPOSE: Childhood dental caries and malnutrition share a bi-directional relationship and represent significant public health challenges. This study aimed to evaluate the effectiveness of a Common Risk Factor Strategy-based intervention in improving childhood oral health and nutrition among preschool and primary school tribal children in Kerala, India. METHODS: This pre-post quasi-experimental study was conducted among tribal children and their caregivers. Baseline assessments included knowledge of oral health, childhood dental caries, and nutrition, along with evaluations of oral health and nutritional status using validated questionnaires and indices. The intervention comprised oral hygiene awareness, dietary counseling, caries prevention through fluoride varnish application, arrest of cavitated lesions using silver diamine fluoride (SDF), curative dental treatment, and the regular provision of toothpaste and toothbrushes. The effectiveness of these interventions was assessed after one year. RESULTS: A total of 95 children (mean age: 4.47 +/- 1.42 years) and their caregivers participated in the study. Post-intervention, there was a significant increase in mean KAP childhood caries assessed using 24 point scale [mean difference (MD): 14.52 +/- 5.01] and nutrition knowledge assessed using 10 point scale (MD: 3.67 +/- 3.42). The mean number of decayed teeth significantly decreased from 7.71 +/- 3.59 to 1.43 +/- 0.53, accompanied by notable improvements in oral hygiene and nutritional indicators. Among children under 5 years, weight-for-age and weight-for-length Z-scores improved significantly following the intervention (p < 0.05). CONCLUSIONS: This study highlights the effectiveness of an integrated medical-dental approach in addressing childhood oral health and malnutrition. Strengthening early prevention strategies through the Common Risk Factor Approach can serve as a sustainable model to improve overall child health and well-being in vulnerable populations. Prioritizing such holistic interventions in public health policies can be a game-changer in reducing health inequities. CI - (c) 2026 Janakiram, Ramanarayanan, James, Raj, Babu and Vasudevan. FAU - Janakiram, Chandrashekar AU - Janakiram C AD - Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi, India. FAU - Ramanarayanan, Venkitachalam AU - Ramanarayanan V AD - Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi, India. FAU - James, Anju AU - James A AD - Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi, India. FAU - Raj, Arya S AU - Raj AS AD - Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi, India. FAU - Babu, Anna Maria AU - Babu AM AD - Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi, India. FAU - Vasudevan, Sanjeev AU - Vasudevan S AD - Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi, India. LA - eng PT - Journal Article DEP - 20260216 PL - Switzerland TA - Front Oral Health JT - Frontiers in oral health JID - 9918227262706676 PMC - PMC12950718 OTO - NOTNLM OT - childhood dental caries OT - common risk factor approach OT - dental caries OT - malnutrition OT - oral health COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author CJ declares that he is an editorial board member of Frontiers at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/03/04 07:15 MHDA- 2026/03/04 07:16 PMCR- 2026/02/16 CRDT- 2026/03/04 04:28 PHST- 2025/07/25 00:00 [received] PHST- 2026/01/02 00:00 [revised] PHST- 2026/01/05 00:00 [accepted] PHST- 2026/03/04 07:16 [medline] PHST- 2026/03/04 07:15 [pubmed] PHST- 2026/03/04 04:28 [entrez] PHST- 2026/02/16 00:00 [pmc-release] AID - 10.3389/froh.2026.1673066 [doi] PST - epublish SO - Front Oral Health. 2026 Feb 16;7:1673066. doi: 10.3389/froh.2026.1673066. eCollection 2026. PMID- 41775761 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Mar 3 TI - Identifying neuromuscular and mental fatigue in elite youth table tennis players using machine learning. LID - 10.1038/s41598-026-40324-w [doi] LID - 11812 AB - Performance in table tennis is known to be affected by both mental and physical fatigue. However, accurately predicting a player's fatigue state remains challenging, particularly when using non-intrusive measurement protocols. This study proposes a methodology for detecting fatigue based on the analysis of players' movement patterns following controlled fatigue induction in young elite table tennis players. Player movements were recorded using an instrumented racket equipped with an accelerometer and pressure sensors. Mental and physical fatigue were induced using established protocols and were validated through significant changes in reference markers, including the Rating of Perceived Exertion for mental fatigue (p < 0.05) and Maximum Voluntary Contraction for physical fatigue (p < 0.05). The resulting labelled datasets were used to train supervised machine learning models for both binary fatigue detection and multiclass fatigue classification. Among the evaluated models, K-Nearest Neighbors and Random Forest achieved the best performance, with recognition rates of approximately 84% for binary classification and 82% for multiclass classification. These results demonstrate that combining formal fatigue induction with instrumented movement analysis enables the creation of reliable datasets for predicting players' fatigue states from their gestures. CI - (c) 2026. The Author(s). FAU - Delumeau, Thibault AU - Delumeau T AD - Nantes Universite, Oniris, CNRS, GEPEA, UMR 6144, F-44470, Carquefou, France. thibault.delumeau@univ-nantes.fr. FAU - Deschamps, Thibault AU - Deschamps T AD - Nantes Universite, Mouvement - Interactions - Performance, MIP, UR4334, F-44000, Nantes, France. FAU - Plot, Christophe AU - Plot C AD - Nantes Universite, Oniris, CNRS, GEPEA, UMR 6144, F-44470, Carquefou, France. FAU - Le Carpentier, Eric AU - Le Carpentier E AD - Nantes Universite, Ecole Centrale Nantes, CNRS, LS2N, UMR 6004, F-44000, Nantes, France. FAU - Mousseau, Pierre AU - Mousseau P AD - Nantes Universite, Oniris, CNRS, GEPEA, UMR 6144, F-44470, Carquefou, France. LA - eng PT - Journal Article DEP - 20260303 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Machine Learning MH - *Mental Fatigue/diagnosis/physiopathology MH - Male MH - *Racquet Sports/physiology MH - *Muscle Fatigue/physiology MH - *Tennis MH - Predictive Learning Models MH - *Athletes MH - Classification Algorithms MH - Athletic Performance/physiology MH - *Fatigue/diagnosis MH - Random Forest PMC - PMC13065852 OTO - NOTNLM OT - Fatigue OT - Machine learning OT - Racket OT - Sensors OT - Table tennis COIS- Competing interests: The authors declare no competing interests. Informed consent: The authors confirm that all methods presented in this paper were conducted in accordance with the Declaration of Helsinki and its latest amendments. The local ethics committee for non-interventional research at Nantes University (n degrees IRB: IORG0011023) has approved the presented procedures. The authors confirm that informed consent was obtained from all subjects and/or their legal representative. Consent for publication: The authors declare that informed consent was obtained from all subjects and/or their legal representative for the publication of personal information/images in open-access online scientific publications, and that data collection was carried out only after obtaining their informed consent. EDAT- 2026/03/04 01:17 MHDA- 2026/04/10 00:33 PMCR- 2026/03/03 CRDT- 2026/03/03 23:17 PHST- 2025/09/18 00:00 [received] PHST- 2026/02/12 00:00 [accepted] PHST- 2026/04/10 00:33 [medline] PHST- 2026/03/04 01:17 [pubmed] PHST- 2026/03/03 23:17 [entrez] PHST- 2026/03/03 00:00 [pmc-release] AID - 10.1038/s41598-026-40324-w [pii] AID - 40324 [pii] AID - 10.1038/s41598-026-40324-w [doi] PST - epublish SO - Sci Rep. 2026 Mar 3;16(1):11812. doi: 10.1038/s41598-026-40324-w. PMID- 41774440 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 9 IP - 3 DP - 2026 Mar 2 TI - Ultraprocessed Food Consumption and Behavioral Outcomes in Canadian Children. PG - e260434 LID - 10.1001/jamanetworkopen.2026.0434 [doi] LID - e260434 AB - IMPORTANCE: Ultraprocessed foods (UPF) contribute to nearly half of energy intake among preschool-aged children in Canada, yet their impact on behavioral and emotional functioning remains underexplored. OBJECTIVE: To examine the associations between UPF intake at age 3 years and behavioral outcomes at age 5 years. DESIGN, SETTING, AND PARTICIPANTS: This cohort study included children with dietary and behavioral data from September 2011 to April 2018 in the CHILD Cohort Study, a prospective Canadian pregnancy cohort. Data analysis was done between February to July 2025. EXPOSURE: UPF intake at age 3 years was assessed by a 112-item food frequency questionnaire and categorized using the NOVA system. MAIN OUTCOMES AND MEASURES: Behavior was measured using the validated Child Behavior Checklist (CBCL; range 0-100; higher scores indicating more adverse symptoms). UPF intake measured as a continuous percentage of energy was examined using multivariable-adjusted linear regression models accounting for maternal diet, birth factors, infant feeding, and sociodemographic and early-childhood characteristics. A multivariable-adjusted substitution model estimated the association of statistically replacing 10% energy from UPF with minimally processed foods (MPF) among all children. RESULTS: Among 2077 participants, 1092 (52.6%) were male; 1376 children (66.2%) were White, 480 children (23.1%) were multiracial, and 221 children (10.7%) were identified as another ethnic group. At age 3 years, UPF contributed a mean (SD) of 45.5% (11.6%) of total energy intake. At age 5 years, the mean (SD) CBCL scores were 44.6 (9.1) for internalizing, 39.6 (9.4) for externalizing, and 41.2 (9.0) for total behavior. Each 10% increase in energy from UPF was associated with higher CBCL internalizing (beta = 0.81 [95% CI, 0.43 to 1.19]), externalizing (beta = 0.47 [95% CI, 0.08 to 0.87]), and total (beta = 0.64 [95% CI, 0.27 to 1.01]) scores. Substitution of 10% energy from UPF with MPF was associated with lower internalizing (beta = -0.91 [95% CI, -1.33 to -0.49]), externalizing (beta = -0.49 [95% CI, -0.93 to -0.06]), and total (beta = -0.70 [95% CI, -1.12 to -0.29]) scores. CONCLUSIONS AND RELEVANCE: In this cohort study of preschoolers in Canada, higher UPF intake was associated with adverse behavioral and emotional symptoms by age 5 years. These findings suggest that replacing UPF with MPF during the preschool years may support healthier behavioral development, with potential benefits for long-term mental health. These findings also support ongoing policy actions that promote MPF and underscore the need for early-life dietary interventions. FAU - Kavanagh, Meaghan E AU - Kavanagh ME AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. FAU - Chen, Zheng Hao AU - Chen ZH AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. FAU - Tamana, Sukhpreet K AU - Tamana SK AD - Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. FAU - Moraes, Theo J AU - Moraes TJ AD - Department of Paediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. AD - Department of Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada. FAU - Simons, Elinor AU - Simons E AD - Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. FAU - Turvey, Stuart E AU - Turvey SE AD - Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. FAU - Subbarao, Padmaja AU - Subbarao P AD - Department of Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada. AD - Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. AD - Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. FAU - Mandhane, Piushkumar J AU - Mandhane PJ AD - Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada. AD - Faculty of Medicine, University College Sedaya International, Kuala Lumpur, Malaysia. FAU - Miliku, Kozeta AU - Miliku K AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. AD - Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260302 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Humans MH - Female MH - Child, Preschool MH - Food, Processed MH - Canada/epidemiology MH - Male MH - *Child Behavior/psychology MH - Prospective Studies MH - Energy Intake MH - Feeding Behavior MH - Cohort Studies MH - *Diet PMC - PMC12958080 COIS- Conflict of Interest Disclosures: Dr Moraes reported receiving grants from the Canadian Institute for Health Research (CIHR), Cystic Fibrosis Canada, and the Physicians' Services Incorporated Foundation outside the submitted work. Dr Simons reported grants from CIHR and serving on the faculties of Children's Hospital Research Institute of Manitoba and University of Manitoba outside the submitted work. Dr Mandhane reported nonfinancial support from Fairly AI and grants from CIHR and Women's and Children's Health Research Institute outside the submitted work. Dr Miliku reported receiving grants from CIHR and Heart and Stroke outside the submitted work. No other disclosures were reported. EDAT- 2026/03/03 12:32 MHDA- 2026/03/06 19:43 PMCR- 2026/03/03 CRDT- 2026/03/03 11:32 PHST- 2026/03/06 19:43 [medline] PHST- 2026/03/03 12:32 [pubmed] PHST- 2026/03/03 11:32 [entrez] PHST- 2026/03/03 00:00 [pmc-release] AID - 2845768 [pii] AID - zoi260032 [pii] AID - 10.1001/jamanetworkopen.2026.0434 [doi] PST - epublish SO - JAMA Netw Open. 2026 Mar 2;9(3):e260434. doi: 10.1001/jamanetworkopen.2026.0434. PMID- 41774199 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260628 IS - 1432-1246 (Electronic) IS - 0340-0131 (Linking) VI - 99 IP - 2 DP - 2026 Mar 3 TI - DNA methylation as an epigenetic marker of children's exposure to traffic-related air pollution in the Klang Valley, Malaysia. LID - 16 [pii] LID - 10.1007/s00420-026-02204-8 [doi] AB - PURPOSE: Traffic-related air pollution (TRAP) poses significant health risks to children. While adverse outcomes have been reported, the biological mechanisms underlying these effects remain unclear. This study investigates the association between TRAP exposure and DNA methylation (DNAm) changes in TNFalpha and CYP1A1 genes as potential epigenetic markers among school children in Malaysia. METHODS: A cross-sectional comparative study was conducted involving 248 children aged 7-11 years from high-traffic (HT) and low-traffic (LT) areas in the Klang Valley. Environmental monitoring was performed at both schools and residences to measure levels of PM10, PM2.5, PM1, NO2, SO2, O3, CO, total volatile organic compounds (TVOC), and black carbon (BC). Dietary intake and other potential confounders were assessed via validated questionnaires. Saliva samples were collected and analyzed for DNAm status using methylation-specific polymerase chain reaction (MS-PCR) targeting TNFalpha and CYP1A1 genes. RESULTS: Pollutant levels were significantly elevated in HT schools (p < 0.001), whereas LT schools recorded higher CO2 concentrations. Children in HT areas had significantly higher methylation in TNFalpha (54.0% vs. 37.1%; OR = 2.0, p = 0.007) and CYP1A1 (51.6% vs. 37.9%; OR = 1.7, p = 0.030). TNFalpha methylation was associated with NO2 exposure (OR = 3.0, 95% CI 0.88-1.95, p = 0.036), while CYP1A1 methylation was linked to BC exposure (OR = 2.0, 95% CI 1.02-2.03, p = 0.019). No significant association was observed for residential TRAP exposure. CONCLUSION: TRAP exposure in school environments is associated with gene-specific epigenetic modifications in children, suggesting potential utility of DNAm as an early biomarker and reinforcing the need for targeted mitigation strategies. FAU - Jalaludin, Juliana AU - Jalaludin J AUID- ORCID: 0000-0002-7910-6945 AD - Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. AD - Emerging Pollutant, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. FAU - Suhaimi, Nur Faseeha AU - Suhaimi NF AUID- ORCID: 0000-0002-5923-8713 AD - Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. nurfaseeha@upm.edu.my. FAU - Abubakar, Suhaili AU - Abubakar S AUID- ORCID: 0000-0002-2217-4509 AD - Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. LA - eng GR - FRGS/1/2019/SKK06/UPM/02/6/Ministry of Higher Education Malaysia/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260303 PL - Germany TA - Int Arch Occup Environ Health JT - International archives of occupational and environmental health JID - 7512134 RN - 0 (Tumor Necrosis Factor-alpha) RN - EC 1.14.14.1 (Cytochrome P-450 CYP1A1) RN - 0 (Air Pollutants) RN - 0 (Biomarkers) RN - EC 1.14.14.1 (CYP1A1 protein, human) RN - 0 (Vehicle Emissions) SB - IM MH - Humans MH - *DNA Methylation MH - Malaysia MH - Child MH - Cross-Sectional Studies MH - Female MH - Tumor Necrosis Factor-alpha/genetics MH - *Environmental Exposure/analysis/adverse effects MH - *Traffic-Related Pollution/analysis/adverse effects MH - Male MH - Cytochrome P-450 CYP1A1/genetics MH - *Air Pollutants/analysis/adverse effects MH - Environmental Monitoring MH - Biomarkers MH - *Vehicle Emissions/analysis MH - Epigenesis, Genetic MH - Saliva/chemistry MH - *Air Pollution/analysis/adverse effects OTO - NOTNLM OT - Black carbon OT - Nitrogen dioxide OT - School children OT - School environments OT - Traffic COIS- Declarations. Conflict of interest: The authors have no conflict of interest. EDAT- 2026/03/03 12:32 MHDA- 2026/06/27 12:38 CRDT- 2026/03/03 11:17 PHST- 2025/10/02 00:00 [received] PHST- 2026/01/23 00:00 [accepted] PHST- 2026/06/27 12:38 [medline] PHST- 2026/03/03 12:32 [pubmed] PHST- 2026/03/03 11:17 [entrez] AID - 10.1007/s00420-026-02204-8 [pii] AID - 10.1007/s00420-026-02204-8 [doi] PST - epublish SO - Int Arch Occup Environ Health. 2026 Mar 3;99(2):16. doi: 10.1007/s00420-026-02204-8. PMID- 41773842 OWN - NLM STAT- MEDLINE DCOM- 20260307 LR - 20260923 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) VI - 37 IP - 3-4 DP - 2026 Mar-Apr 01 TI - Defining Prominauris in the Pediatric Population: A Systematic Review. PG - 668-672 LID - 10.1097/SCS.0000000000012242 [doi] AB - BACKGROUND: Prominauris, or protruding ears, is a common pediatric craniofacial deformity often associated with psychosocial distress. Although otoplasty can address these concerns, there is no standardized classification system to guide diagnosis or surgical decision-making. Existing definitions vary widely and inconsistently account for anatomic and developmental factors such as age and sex. This study aims to systematically review prominauris classification systems and propose a more objective, practical framework. METHODS: A systematic review was conducted using MEDLINE, Embase, CINAHL, and Cochrane Trials to identify studies defining or classifying prominauris in individuals under 18 years old. Two independent reviewers screened articles, extracted data on classification features and methods, and performed a critical appraisal using 6 predefined criteria, including clarity, generalizability, objectivity, reproducibility, and demographic considerations. RESULTS: Of the 2049 articles screened, 15 met the inclusion criteria. Classifications varied considerably: 47% used subjective assessments, 40% used physical measurements, and 13% used digital tools. Most incorporated multiple auricular features, with inconsistent use of anatomic landmarks and measurement thresholds. Only one system accounted for age, and one for sex; no classification integrated both. None met all 6appraisal criteria. On the basis of these findings, the authors propose a novel 2-step classification system using mastoid-helical distance at the tragal level, with age-specific and sex-specific thresholds derived from a large pediatric anthropometric data set. CONCLUSIONS: Existing prominauris classification systems are inconsistent and lack demographic variability. The authors' proposed system offers a simple, reproducible, objective approach that accounts for age and sex, facilitating more consistent diagnosis and surgical decision-making. Validation studies are warranted. CI - Copyright (c) 2025 by Mutaz B. Habal, MD. FAU - Covone, Jason AU - Covone J AUID- ORCID: 0009-0004-0802-0310 AD - Division of Plastic Surgery, Universite de Montreal. FAU - Bouhadana, Gabriel C AU - Bouhadana GC AD - Division of Plastic Surgery, Universite de Montreal. FAU - Cugno, Sabrina AU - Cugno S AD - Division of Plastic Surgery, Universite de Montreal. AD - Division of Plastic Surgery, McGill University, Montreal, QC, Canada. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Systematic Review DEP - 20260225 PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 SB - IM MH - Humans MH - Child MH - *Ear, External/abnormalities/surgery MH - Adolescent OTO - NOTNLM OT - Congenital adnexa OT - craniofacial overgrowth OT - evidence based care OT - prominauris OT - prominent ear OT - recontruction of head and neck OT - systematic review COIS- The authors report no conflicts of interest. EDAT- 2026/03/03 12:31 MHDA- 2026/03/07 18:38 CRDT- 2026/03/03 08:57 PHST- 2025/09/29 00:00 [received] PHST- 2025/10/12 00:00 [accepted] PHST- 2026/03/07 18:38 [medline] PHST- 2026/03/03 12:31 [pubmed] PHST- 2026/03/03 08:57 [entrez] AID - 00001665-202603000-00059 [pii] AID - 10.1097/SCS.0000000000012242 [doi] PST - ppublish SO - J Craniofac Surg. 2026 Mar-Apr 01;37(3-4):668-672. doi: 10.1097/SCS.0000000000012242. Epub 2026 Feb 25. PMID- 41773480 OWN - NLM STAT- MEDLINE DCOM- 20260608 LR - 20260608 IS - 1099-0968 (Electronic) IS - 1072-4133 (Linking) VI - 34 IP - 4 DP - 2026 Jul TI - Validation of DSM-5 Severity Specifiers for Bulimia Nervosa and Binge Eating Disorder and an Alternative Specifier for Binge Eating Disorder in a Korean Cohort. PG - 1075-1088 LID - 10.1002/erv.70095 [doi] AB - OBJECTIVE: We examined the clinical validity of DSM-5 severity specifiers for bulimia nervosa (BN) and binge eating disorder (BED) in Korean outpatients. METHOD: Seven hundred ninety-nine outpatients with BN (n = 668; mean age = 23.7 years; 95% female; mean BMI = 20.54 kg/m(2)) or BED (n = 131; mean age = 26.1 years; 89% female; mean BMI = 25.07 kg/m(2)) were recruited from an eating disorders clinic. For BN, we assessed the validity of severity specifiers based on purging-type behaviours and overall compensatory behaviours. For BED, we examined the validity of the current severity specifier and an alternative specifier with an adjusted threshold based on the frequency distribution. RESULTS: For BN, severity based on purging-type behaviours differentiated BMI and self-injury, whereas severity based on overall compensatory behaviours differentiated the level of weight suppression as well as eating-related and general psychopathology. In both classifications, increasing severity was linked to a greater likelihood of self-injury. For BED, 90% of patients were classified as mild-to-moderate using the current specifier. The adjusted index correlated more strongly with EDE-Q shape concerns and global scores than the current index. CONCLUSIONS: The BN specifier differentiated clinical variables across severity groups. The adjusted BED specifier may better differentiate severity in the Korean population than the DSM-5 specifier, suggesting the potential benefit of cultural adjustments. CI - (c) 2026 The Author(s). European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd. FAU - An, Zhen AU - An Z AUID- ORCID: 0000-0002-6233-9013 AD - Institute of Eating Disorders and Mental Health, Inje University, Seoul, South Korea. AD - Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia. FAU - Kim, Youl-Ri AU - Kim YR AUID- ORCID: 0000-0002-5538-7180 AD - Institute of Eating Disorders and Mental Health, Inje University, Seoul, South Korea. AD - Department of Psychiatry, Ilsan Paik Hospital, Inje University, Goyang, South Korea. AD - Institute for Gender Research, Seoul National University, Seoul, South Korea. FAU - Treasure, Janet AU - Treasure J AUID- ORCID: 0000-0003-0871-4596 AD - Centre for Research in Eating and Weight Disorders (CREW), Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK. LA - eng GR - 2021R1A2C2009668/National Research Foundation of Korea/ PT - Journal Article PT - Validation Study DEP - 20260303 PL - England TA - Eur Eat Disord Rev JT - European eating disorders review : the journal of the Eating Disorders Association JID - 9436977 SB - IM MH - Humans MH - Female MH - *Bulimia Nervosa/diagnosis/classification/psychology MH - *Binge-Eating Disorder/diagnosis/classification/psychology MH - *Diagnostic and Statistical Manual of Mental Disorders MH - Adult MH - Republic of Korea MH - Severity of Illness Index MH - Young Adult MH - Reproducibility of Results MH - Cohort Studies MH - Body Mass Index MH - Adolescent OTO - NOTNLM OT - binge eating disorder OT - bulimia nervosa OT - diagnostic and statistical manual of mental disorders, fifth edition (DSM-5) OT - severity specifier EDAT- 2026/03/03 06:30 MHDA- 2026/06/08 19:41 CRDT- 2026/03/03 05:52 PHST- 2025/12/11 00:00 [revised] PHST- 2025/03/24 00:00 [received] PHST- 2026/02/20 00:00 [accepted] PHST- 2026/06/08 19:41 [medline] PHST- 2026/03/03 06:30 [pubmed] PHST- 2026/03/03 05:52 [entrez] AID - 10.1002/erv.70095 [doi] PST - ppublish SO - Eur Eat Disord Rev. 2026 Jul;34(4):1075-1088. doi: 10.1002/erv.70095. Epub 2026 Mar 3. PMID- 41772507 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Mar 2 TI - Prediction tool for independent walking in children with dyskinetic cerebral palsy: a modeling study. LID - 10.1186/s12887-026-06649-1 [doi] LID - 272 AB - PURPOSE: Independent walking in children with Dyskinetic Cerebral Palsy (DCP) profoundly influences long-term quality of life.However, studies on the relationship between independent walking and high-risk factors in children with Dyskinaetic Cerebral Palsy (DCP) remain limited, and a predictive model for independent walking in this population has not yet been established.This study aimed to develop and validate a nomogram model based on multivariate clinical indicators to predict the probability of achieving independent walking by 7 years of age, thereby supporting early clinical decision-making and individualized rehabilitation planning. METHODS: The study was registered with the Chinese Clinical Trial Registry (Registration number: ChiCTR2300068075) on February 6, 2023. This retrospective study included 456 children with DCP registered in the Henan Provincial Children's Cerebral Palsy Registration Management Platform and the medical record system of the Third Affiliated Hospital of Zhengzhou University from January 2004 to December 2022. The primary outcome was independent walking achieved at or before age 7. Follow-up was conducted through on-site assessments and telephone/WeChat interviews from January 2023 to December 2024. Using the R caret package, participants were randomly divided into training and validation sets (7:3 ratio). Independent predictors were identified through univariate and multivariate Cox regression analyses, and a nomogram was constructed. Model performance was assessed using the concordance index (C-index), Area Under the Receiver Operating Characteristic Curve (AUC), calibration curves, and Decision Curve Analysis (DCA). RESULTS: Of the 456 children, 167 (36.60%) achieved independent walking at or before age 7. The numbers of children achieving independent walking at ages 2 to 7 were 17 (3.73%), 20 (4.38%), 25 (5.48%), 25 (5.48%), 33 (7.23%), and 47 (10.30%), respectively. Multivariate Cox regression identified neonatal seizures, cognitive impairment, GMFCS level at 2 years, epilepsy, and independent sitting before age 2 as significant predictors (P < 0.05). The nomogram demonstrated excellent discrimination, with a C-index of 0.926 in the training set and 0.942 in the validation set. Calibration curves indicated strong agreement between predicted and observed outcomes, and DCA confirmed substantial clinical net benefit within the threshold probability range of 4-7 years. CONCLUSION: We developed and validated a clinically applicable nomogram model for predicting independent walking by age 7 in children with DCP. Key predictors included early sitting ability, GMFCS level at 2 years, cognitive impairment, neonatal seizures, and epilepsy. This quantitative tool supports individualized rehabilitation strategies, facilitates informed clinical decisions, and may improve long-term outcomes for affected children. FAU - Qiao, Lusha AU - Qiao L AD - Department of Rehabilitation Medicine, Department of Paediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. AD - Department of Pediatrics, Anyang People's Hospital, Anyang, Henan, 455000, China. FAU - Chen, Gongxun AU - Chen G AD - Department of Rehabilitation Medicine, Department of Paediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. FAU - Wang, Yiwen AU - Wang Y AD - Department of Rehabilitation Medicine, Department of Paediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. FAU - Cheng, Zhiwei AU - Cheng Z AD - Medical Records Management Department, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. FAU - Hui, Zhichong AU - Hui Z AD - Department of Rehabilitation Medicine, Department of Paediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. FAU - Gao, Wenli AU - Gao W AD - Department of Pediatrics, Anyang People's Hospital, Anyang, Henan, 455000, China. FAU - Shi, Kaili AU - Shi K AD - Department of Rehabilitation Medicine, Department of Paediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. FAU - Wang, Mingmei AU - Wang M AD - Department of Rehabilitation Medicine, Department of Paediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. FAU - Ding, Xuexing AU - Ding X AD - Department of Pediatrics, Anyang People's Hospital, Anyang, Henan, 455000, China. FAU - Wang, Yongxia AU - Wang Y AD - Department of Pediatrics, Anyang People's Hospital, Anyang, Henan, 455000, China. FAU - Zhang, Guangyu AU - Zhang G AD - Department of Rehabilitation Medicine, Department of Paediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. FAU - Yang, Lei AU - Yang L AD - Department of Rehabilitation Medicine, Department of Paediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. FAU - Li, Sansong AU - Li S AD - Department of Rehabilitation Medicine, Department of Paediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. FAU - Zhu, Dengna AU - Zhu D AD - Department of Rehabilitation Medicine, Department of Paediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. zhudengna@126.com. AD - Institute of Neuroscience, Zhengzhou University, Zhengzhou, 450001, Henan, China. zhudengna@126.com. AD - Key Laboratory of Pediatrics Brain Injury in Henan Province, Henan Provincial Pediatrics Clinical Medical Research Centre, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. zhudengna@126.com. LA - eng SI - ChiCTR/ChiCTR2300068075 GR - 232102310135/Key R&D and Promotion Special Project (Science and Technology Tackling) of Henan Province/ GR - SBGJ202402069/Key Project of Medical Science and Technology Tackling Plan of Henan Province 2024/ PT - Journal Article PT - Validation Study DEP - 20260302 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology/rehabilitation MH - Child MH - Retrospective Studies MH - Female MH - *Walking MH - Male MH - *Nomograms MH - Child, Preschool PMC - PMC13059563 OTO - NOTNLM OT - Dyskinetic cerebral palsy OT - Independent walking OT - Nomogram OT - Prediction model COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki. The research protocol was approved by the Ethics Committee of the Third Affiliated Hospital of Zhengzhou University (Ethic Approval No. 2022-369-01) and registered with the Chinese Clinical Trial Registry (ChiCTR2300068075) before initiation. Informed consent was waived for retrospective data, but obtained from families for follow-up. Competing interests: The authors declare no competing interests. EDAT- 2026/03/03 00:30 MHDA- 2026/06/27 12:37 PMCR- 2026/03/02 CRDT- 2026/03/02 23:47 PHST- 2025/12/07 00:00 [received] PHST- 2026/02/13 00:00 [accepted] PHST- 2026/06/27 12:37 [medline] PHST- 2026/03/03 00:30 [pubmed] PHST- 2026/03/02 23:47 [entrez] PHST- 2026/03/02 00:00 [pmc-release] AID - 10.1186/s12887-026-06649-1 [pii] AID - 6649 [pii] AID - 10.1186/s12887-026-06649-1 [doi] PST - epublish SO - BMC Pediatr. 2026 Mar 2;26(1):272. doi: 10.1186/s12887-026-06649-1. PMID- 41771441 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1541-6100 (Electronic) IS - 0022-3166 (Print) IS - 0022-3166 (Linking) VI - 156 IP - 5 DP - 2026 May TI - Marine n-3 Long-Chain Polyunsaturated Fatty Acid Intake in Pregnancy and Risk of Early Life Infections in 3 Nordic Cohorts: A HEDIMED Consortium Study. PG - 101456 LID - S0022-3166(26)00105-7 [pii] LID - 10.1016/j.tjnut.2026.101456 [doi] LID - 101456 AB - BACKGROUND: n-3 (omega-3) long-chain polyunsaturated fatty acids (n-3 LCPUFAs) have anti-inflammatory effects that may influence immune-mediated diseases. OBJECTIVES: We investigated whether higher maternal pregnancy intake of n-3 LCPUFA is associated with a lower incidence of infections in young children. METHODS: We used data from 3 Nordic cohorts: the Norwegian Mother, Father and Child Cohort study (MoBa, n = 76,026), the Finnish Diabetes Prediction and Prevention Study (DIPP, n = 560), and the Copenhagen Prospective Studies on Asthma in Childhood 2010 cohort (COPSAC(2010), n = 680). Childhood infections up to age 36 mo were assessed using questionnaires in MoBa, coxsackievirus B 1-6 (CVB1-6) neutralizing antibodies in DIPP, and pathogenic viral PCR identification from acute respiratory episodes in COPSAC(2010). Maternal n-3 LCPUFA intake was assessed through validated food frequency questionnaires in MoBa and DIPP, whereas COPSAC(2010) used a randomized trial design where pregnant women received fish oil capsules or a placebo. RESULTS: Higher n-3 LCPUFA intake was not significantly associated with lower respiratory tract infection (adjusted incidence rate ratio [aIRR]: 0.99; 95% CI: 0.94-1.03) but was associated with a reduced risk of upper respiratory tract infections (aIRR: 0.99; 95% CI: 0.98-0.99) and gastroenteritis (aIRR: 0.96; 95% CI: 0.95-0.98) per g/d up to age 36 mo in MoBa. The DIPP study found no association between n-3 LCPUFA intake and having >/=1 CVB infection (adjusted odds ratio: 1.74; 95% CI: 0.64-4.72, per g/d). The COPSAC(2010) trial found no significant effects of the intervention for pathogen-specific respiratory episodes (IRR: 0.86; 95% CI: 0.69-1.07). CONCLUSIONS: This study does not provide consistent evidence that higher maternal n-3 LCPUFA pregnancy intake reduces the risk of infections in early childhood. CLINICAL TRIAL REGISTRY: This trial was registered as NCT00798226, https://clinicaltrials.gov/study/NCT00798226. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Rantala, Aino K AU - Rantala AK AD - Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway; Center for Environmental and Respiratory Health Research (CERH), Research Unit of Population Health, University of Oulu, Oulu, Finland. Electronic address: aino.rantala@oulu.fi. FAU - Hakola, Leena AU - Hakola L AD - Department of Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland; Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, Finland; Tampere University Hospital, Research, Development and Innovation Center, Tampere, Finland. Electronic address: leena.hakola@tuni.fi. FAU - Brustad, Nicklas AU - Brustad N AD - Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, Copenhagen, Denmark. FAU - Tapia, German AU - Tapia G AD - Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway. FAU - Hard Af Segerstad, Elin M AU - Hard Af Segerstad EM AD - Department of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway; Celiac Disease and Diabetes Unit, Clinical Sciences Malmoe, Lund University, Malmoe, Sweden. FAU - Lehtonen, Jussi AU - Lehtonen J AD - Department of Virology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. FAU - Thorsen, Jonathan AU - Thorsen J AD - Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. FAU - Akerlund, Mari AU - Akerlund M AD - Department of Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland; Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, Finland. FAU - Parr, Christine L AU - Parr CL AD - Norwegian Scientific Committee for Food and Environment, Oslo, Norway. FAU - Magnus, Maria C AU - Magnus MC AD - Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway. FAU - Lund-Blix, Nicolai A AU - Lund-Blix NA AD - Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway; The Norwegian Childhood Diabetes Registry, Division of Childhood and Adolescent Medicine, Oslo University Hospital, Oslo, Norway. FAU - Stokholm, Jakob AU - Stokholm J AD - Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, Copenhagen, Denmark; Department of Food Science, University of Copenhagen, Frederiksberg C, Denmark. FAU - Knip, Mikael AU - Knip M AD - Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Department of Pediatrics, Tampere University Hospital, Tampere, Finland. FAU - Toppari, Jorma AU - Toppari J AD - Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, and Centre for Population Health Research, and InFLAMES Research Centre, University of Turku, Turku, Finland; Department of Pediatrics, Turku University Hospital, Turku, Finland. FAU - Stordal, Ketil AU - Stordal K AD - Department of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway; Department of Paediatric Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. FAU - Veijola, Riitta AU - Veijola R AD - Department of Pediatrics, PEDEGO Research Unit, Medical Research Center, University of Oulu, Oulu, Finland; Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland. FAU - Hyoty, Heikki AU - Hyoty H AD - Department of Virology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Department of Pediatrics, Tampere University Hospital, Tampere, Finland; Fimlab Laboratories, Tampere, Finland. FAU - Virtanen, Suvi M AU - Virtanen SM AD - Department of Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland; Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, Finland; Tampere University Hospital, Research, Development and Innovation Center, Tampere, Finland; Center for Child, Adolescent and Maternal Health Research, Tampere University and Tampere University Hospital, Tampere. FAU - Bonnelykke, Klaus AU - Bonnelykke K AD - Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. FAU - Stene, Lars C AU - Stene LC AD - Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway. CN - HEDIMED Investigator Group LA - eng SI - ClinicalTrials.gov/NCT00798226 GR - N01ES75558/ES/NIEHS NIH HHS/United States GR - U01 NS047537/NS/NINDS NIH HHS/United States PT - Journal Article PT - Observational Study DEP - 20260228 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 RN - 0 (Fatty Acids, Omega-3) RN - 0 (Fish Oils) SB - IM MH - Adult MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Pregnancy MH - Cohort Studies MH - *Fatty Acids, Omega-3/administration & dosage/pharmacology MH - Finland/epidemiology MH - Fish Oils/administration & dosage MH - *Infections/epidemiology MH - *Maternal Nutritional Physiological Phenomena MH - Norway/epidemiology MH - Prospective Studies MH - Risk Factors MH - Randomized Controlled Trials as Topic PMC - PMC13197902 OTO - NOTNLM OT - COPSAC OT - DIPP OT - MoBa OT - childhood OT - cohort study OT - dietary fatty acids OT - infections OT - pregnancy COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/03/03 00:30 MHDA- 2026/05/09 00:33 PMCR- 2026/02/28 CRDT- 2026/03/02 19:13 PHST- 2025/12/29 00:00 [received] PHST- 2026/02/13 00:00 [revised] PHST- 2026/02/24 00:00 [accepted] PHST- 2026/05/09 00:33 [medline] PHST- 2026/03/03 00:30 [pubmed] PHST- 2026/03/02 19:13 [entrez] PHST- 2026/02/28 00:00 [pmc-release] AID - S0022-3166(26)00105-7 [pii] AID - 101456 [pii] AID - 10.1016/j.tjnut.2026.101456 [doi] PST - ppublish SO - J Nutr. 2026 May;156(5):101456. doi: 10.1016/j.tjnut.2026.101456. Epub 2026 Feb 28. PMID- 41769799 OWN - NLM STAT- MEDLINE DCOM- 20260310 LR - 20260813 IS - 1369-7625 (Electronic) IS - 1369-6513 (Print) IS - 1369-6513 (Linking) VI - 29 IP - 2 DP - 2026 Apr TI - Exploring Challenges and Co-Developing a Nutritional Resource for Antenatal Care: A Participatory Stakeholder Engagement Study With Midwives and Public Involvement. PG - e70633 LID - 10.1111/hex.70633 [doi] LID - e70633 AB - BACKGROUND: It is important that midwives discuss good nutrition and optimal weight during antenatal appointments, yet this rarely happens. Earlier research suggests that limited time, plus insufficient knowledge and skills are barriers to this. AIM: To engage antenatal midwives in stakeholder discussions to explore their perspectives on the design and delivery of a nutrition resource. METHODS: This qualitative study used a Participatory Action Research (PAR) approach. Twenty-six midwives (19 community-based; 7 hospital-based) were purposely recruited from four NHS sites in Northwest England. Four stakeholder workshops were co-designed and facilitated by researchers. In Phase 1, midwives reflected on current practice and challenges in delivering diet and weight advice. In Phase 2, they co-developed ideas for practical, acceptable nutrition resources. Data collection included participant-generated artefacts, post-it notes, visual maps, field notes, and verbatim reflections. Data were analysed inductively using Reflexive Thematic Analysis, and reflexivity was maintained throughout, recognising researchers' influence within this participatory design. RESULTS: Two master themes were developed: (1) "We Want to Help, But We're Not Trained for This", highlighting systemic, professional, and emotional barriers to providing support and (2) "Make It Real and Make It Work", midwives' co-produced recommendations for inclusive tools and training that are realistic, culturally sensitive, and integrated into existing workflows. DISCUSSION AND CONCLUSION: Midwives expressed a clear need for improved education and resource support. Despite systemic constraints, they co-produced practical and implementable solutions. Supporting midwives through evidence-based, context-specific tools and training may enhance nutrition conversations in antenatal care and improve maternal and infant health outcomes. PATIENT OR PUBLIC CONTRIBUTION: Three culturally diverse Patient and Public Involvement (PPI) representatives were recruited to assist with the validation of the analytical findings. One was a midwife working in antenatal care; the second was a recent service user (a postnatal woman) with an Eastern European background, and the third was a midwife (currently on maternity leave) with a South American background. Commentary from these PPI representatives was used to validate the analysis and support the interpretation of the data. Additionally, they were invited to provide commentary on the draft manuscript and have been included as co-authors. CI - (c) 2026 The Author(s). Health Expectations published by John Wiley & Sons Ltd. FAU - Abayomi, Julie AU - Abayomi J AUID- ORCID: 0000-0002-8133-5595 AD - Health Research Institute, Edge Hill University, Ormskirk, UK. FAU - Richards, Helen AU - Richards H AD - Liverpool Women's Hospital NHS Trust, Liverpool, UK. FAU - Benavides, Camila AU - Benavides C AD - Liverpool Women's Hospital NHS Trust, Liverpool, UK. FAU - Reyneke, Ekaterina AU - Reyneke E FAU - Newson, Lisa AU - Newson L AUID- ORCID: 0000-0002-5874-8762 AD - School of Psychology, Liverpool John Moores University, Liverpool, UK. LA - eng GR - NIHR305789/National Institute for Health and Care Research/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Health Expect JT - Health expectations : an international journal of public participation in health care and health policy JID - 9815926 SB - IM MH - Qualitative Research MH - *Midwifery/methods MH - Stakeholder Participation MH - Community-Based Participatory Research MH - *Prenatal Care/methods/psychology MH - England MH - *Counseling/methods MH - *Diet, Healthy/nursing MH - Humans MH - Female MH - Pregnancy MH - *Nurse Midwives/psychology MH - Professional Competence MH - Health Knowledge, Attitudes, Practice PMC - PMC12951540 OTO - NOTNLM OT - midwives OT - nutrition OT - pregnancy OT - weight COIS- The authors declare no conflicts of interest. EDAT- 2026/03/02 13:17 MHDA- 2026/03/07 06:39 PMCR- 2026/03/02 CRDT- 2026/03/02 07:23 PHST- 2025/07/31 00:00 [revised] PHST- 2025/05/28 00:00 [received] PHST- 2026/02/19 00:00 [accepted] PHST- 2026/03/07 06:39 [medline] PHST- 2026/03/02 13:17 [pubmed] PHST- 2026/03/02 07:23 [entrez] PHST- 2026/03/02 00:00 [pmc-release] AID - HEX70633 [pii] AID - 10.1111/hex.70633 [doi] PST - ppublish SO - Health Expect. 2026 Apr;29(2):e70633. doi: 10.1111/hex.70633. PMID- 41769120 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Associations of physical activity, disordered eating, and depressive symptoms with academic performance among Saudi university students. PG - 1769363 LID - 10.3389/fpubh.2026.1769363 [doi] LID - 1769363 AB - BACKGROUND AND OBJECTIVES: Academic performance is shaped by various behavioral and psychological factors. However, the effects of physical activity, depressive symptoms, and disordered eating on academic success, particularly among university students in Saudi Arabia, remain underexplored. This study investigates the individual and combined associations of these factors on GPA among Saudi university students. MATERIALS AND METHODS: A cross-sectional survey was conducted from December 2024 to June 2025 involving a non-probability convenience sample of 400 students from various Saudi universities. Data were collected using validated instruments, including the International Physical Activity Questionnaire-Short Form (IPAQ-SF), the Patient Health Questionnaire-9 (PHQ-9) for assessing depression, and the Eating Disorder Examination Questionnaire-Short Form (EDE-QS). Descriptive statistics, chi-square tests, and multiple linear regression analyses were utilized to identify associations and predictors of academic performance. RESULTS: The majority of participants were female (79.8%) with a median age of 21. More than half (53%) reported low levels of physical activity, and 50.7% exhibited clinically significant depressive symptoms. Elevated behavioral symptoms of disordered eating, assessed using the behavioral subscale of the EDE-QS, were commonly observed among participants. Regression analysis showed that adherence to WHO-recommended physical activity levels, enrolment in medical disciplines, and lower behavioral symptoms of eating disorders were associated with higher GPA. In contrast, depression and cognitive eating concerns were not meaningfully associated with academic performance. CONCLUSION: Physical activity and disordered eating behaviors play a crucial role in influencing academic performance among Saudi university students, while depression, despite its high prevalence, did not serve as an independent predictor of GPA. These findings highlight the necessity of implementing integrated health promotion strategies within academic institutions that address both mental health and lifestyle behaviors to enhance student success. CI - Copyright (c) 2026 Alotaibi, Alghamdi, Almousa, Almalkia, Alfaifi, Alturki, Alkahal, Asiri, Almuzaini, Alshahrani, Alqabbani, Almuwais and Alahmari. FAU - Alotaibi, Madawi AU - Alotaibi M AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Alghamdi, Farah AU - Alghamdi F AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Almousa, Nourah AU - Almousa N AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Almalkia, Roaa AU - Almalkia R AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Alfaifi, Reema AU - Alfaifi R AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. AD - Public Health Program, King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia. FAU - Alturki, Hisaah AU - Alturki H AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Alkahal, Hathil AU - Alkahal H AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Asiri, Ruba AU - Asiri R AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Almuzaini, Muzun AU - Almuzaini M AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Alshahrani, Ghaday AU - Alshahrani G AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Alqabbani, Samiah AU - Alqabbani S AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Almuwais, Afrah AU - Almuwais A AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Alahmari, Wafa AU - Alahmari W AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260212 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Female MH - Male MH - Cross-Sectional Studies MH - *Students/psychology/statistics & numerical data MH - Universities MH - *Depression/epidemiology/psychology MH - Young Adult MH - *Exercise/psychology MH - *Feeding and Eating Disorders/epidemiology/psychology MH - *Academic Performance/statistics & numerical data MH - Surveys and Questionnaires MH - Adolescent MH - Adult MH - Academia PMC - PMC12935905 OTO - NOTNLM OT - GPA OT - academic performance OT - depression OT - eating disorders OT - lifestyle behaviors OT - mental health OT - physical activity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/02 13:17 MHDA- 2026/03/06 13:44 PMCR- 2026/02/12 CRDT- 2026/03/02 06:46 PHST- 2025/12/16 00:00 [received] PHST- 2026/01/16 00:00 [revised] PHST- 2026/01/19 00:00 [accepted] PHST- 2026/03/06 13:44 [medline] PHST- 2026/03/02 13:17 [pubmed] PHST- 2026/03/02 06:46 [entrez] PHST- 2026/02/12 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1769363 [doi] PST - epublish SO - Front Public Health. 2026 Feb 12;14:1769363. doi: 10.3389/fpubh.2026.1769363. eCollection 2026. PMID- 41768591 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260926 IS - 1520-6394 (Electronic) IS - 1091-4269 (Print) IS - 1091-4269 (Linking) VI - 2026 DP - 2026 TI - Development and External Validation of a Prediction Model to Identify Suicide Attempters in Treatment-Naive Adolescents With Major Depressive Disorder. PG - 7216497 LID - 10.1155/da/7216497 [doi] LID - 7216497 AB - BACKGROUND: Suicidal behavior in adolescents poses a significant risk, and suicide attempts are the strongest predictors of suicide death. Patients with Major Depressive Disorder (MDD) are at high risk of attempting suicide. However, there is still a lack of effective tools in clinical settings to identify these suicide attempters. METHODS: The study assessed suicidal attempts and their predictive factors in adolescents first diagnosed with MDD from August 1, 2022, to May 31, 2024. Five algorithms were used for model construction: logistic regression, random forest, decision tree, support vector machine, and XGBoost. Finally, we evaluated the performance of the best model using an independent external validation set. RESULTS: The study included 820 untreated adolescent first-visit MDD patients (618 females [75.4%], average age 14.67 +/- 1.69 years). Of these, 481 (58.7%) had disclosed suicidal ideation to others, and 299 (36.5%) reported having attempted suicide. Predictive variables for the outcome included age, grade, BMI z-score, levels of depression and anxiety, sleep quality, history of being left behind, father's occupation, primary residence before age 16, history of non-suicidal self-injury (NSSI) within the last year, and history of disclosure of suicidal ideation. The XGBoost model showed the highest prediction accuracy (ROC_AUC, 0.72; PR_AUC, 0.65) and sensitivity (0.85) after external validation. The history of NSSI within the last year had the strongest predictive effect on suicide attempts, followed by disclosure of suicidal ideation, sleep quality, BMI z-score, and anxiety levels. CONCLUSIONS: Despite including only 11 easily collectible clinical variables, the XGBoost model effectively identifies suicide attempters among untreated adolescent first-visit MDD patients and performs stably in external validation sets. This is beneficial for clinicians to conduct evidence-based suicide prevention efforts. CI - Copyright (c) 2026 Yuqin Song et al. Depression and Anxiety published by John Wiley & Sons Ltd. FAU - Song, Yuqin AU - Song Y AUID- ORCID: 0009-0004-2685-0078 AD - Mental Health Center, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China, hospital-nsmc.com.cn. AD - School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. FAU - Dai, Mengqin AU - Dai M AUID- ORCID: 0009-0004-9091-7847 AD - School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. FAU - Fan, Qiuyue AU - Fan Q AUID- ORCID: 0009-0005-9706-7408 AD - School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. FAU - Pan, Lu AU - Pan L AUID- ORCID: 0009-0006-3450-7696 AD - School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. FAU - Wu, Yuhang AU - Wu Y AUID- ORCID: 0009-0003-3364-9906 AD - School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. FAU - Shao, Jiarui AU - Shao J AUID- ORCID: 0009-0005-0425-5320 AD - School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. FAU - Lin, Cen AU - Lin C AUID- ORCID: 0009-0009-5229-4286 AD - School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. FAU - Luo, Wenxiu AU - Luo W AUID- ORCID: 0009-0006-7352-7059 AD - Mental Health Center, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China, hospital-nsmc.com.cn. AD - School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. FAU - Cen, Yu AU - Cen Y AUID- ORCID: 0009-0004-3917-2069 AD - School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. FAU - Xie, Cailin AU - Xie C AUID- ORCID: 0009-0004-2787-627X AD - School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. FAU - Wang, Xiangli AU - Wang X AUID- ORCID: 0009-0006-2547-938X AD - Center for Vocational Education Research, Shenzhen University of Information Technology, Shenzhen, Guangdong, China. FAU - Luo, Jiaming AU - Luo J AUID- ORCID: 0000-0003-0025-0379 AD - Mental Health Center, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China, hospital-nsmc.com.cn. AD - School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. AD - Key Laboratory of Digital-Intelligent Disease Surveillance and Health Governance, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. LA - eng PT - Journal Article PT - Validation Study DEP - 20260227 PL - United States TA - Depress Anxiety JT - Depression and anxiety JID - 9708816 SB - IM MH - Humans MH - *Major Depressive Disorder/psychology MH - *Suicide, Attempted/statistics & numerical data/psychology MH - Female MH - Adolescent MH - Prediction Algorithms MH - Male MH - Classification Algorithms MH - Predictive Learning Models MH - Boosting Machine Learning Algorithms MH - Random Forest PMC - PMC12947665 OTO - NOTNLM OT - adolescents OT - depression OT - machine learning OT - prediction model OT - suicide attempt COIS- The authors declare no conflicts of interest. EDAT- 2026/03/02 13:16 MHDA- 2026/03/08 06:38 PMCR- 2026/02/27 CRDT- 2026/03/02 06:42 PHST- 2025/01/30 00:00 [received] PHST- 2025/11/11 00:00 [revised] PHST- 2025/12/30 00:00 [accepted] PHST- 2026/03/08 06:38 [medline] PHST- 2026/03/02 13:16 [pubmed] PHST- 2026/03/02 06:42 [entrez] PHST- 2026/02/27 00:00 [pmc-release] AID - DA7216497 [pii] AID - 10.1155/da/7216497 [doi] PST - epublish SO - Depress Anxiety. 2026 Feb 27;2026:7216497. doi: 10.1155/da/7216497. eCollection 2026. PMID- 41766600 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260909 IS - 1550-9109 (Electronic) IS - 0161-8105 (Linking) VI - 49 IP - 7 DP - 2026 Jul 13 TI - Sex differences in sleep disturbances in middle childhood: findings from an urban pediatric cohort study. LID - zsag051 [pii] LID - 10.1093/sleep/zsag051 [doi] AB - STUDY OBJECTIVES: While sleep differs in adult males and females, its variation by sex during childhood is less understood. We examined sex differences in sleep measures in children and explored the influences of selective socio-demographic and health-related factors on these associations. METHODS: The cohort included 323 participants aged 6-12 years who resided predominantly in low-income urban neighborhoods. Sleep duration and maintenance efficiency were assessed using wrist actigraphy. Sleep-disordered breathing (SDB) was assessed from overnight in-home testing. Validated questionnaires assessed sleep-related impairment and sleep disturbance. Linear and logistic regression modeled associations between sex and sleep outcomes, testing for effect modification by demographics, indoor environment, and neighborhood factors. RESULTS: Male children had higher odds for short sleep duration (<8 hours; Odds Ratio [OR] = 1.81, 95% confidence interval [CI] = 1.06, 3.08) and low sleep efficiency (<85%; OR = 2.04, 95% CI = 1.24, 3.35), which persisted after adjusting for health-related factors. Male sex was associated with a 17.4% higher geometric mean of SDB respiratory event frequency (p < .05). Effect modification analysis showed stronger associations between male sex and lower sleep efficiency for children older than 10 years, between male sex and short sleep duration for minority children, and between male sex and SDB for children of mothers with lower education. No sex differences were observed in parent-reported sleep outcomes. CONCLUSIONS: Male children were at higher risk for several objectively measured but not for caregiver-reported sleep outcomes; findings were unexplained by common health problems. Risk appeared further elevated in males who were older than 10 years and were of minority ethno-racial background or from homes with low maternal education. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of Sleep Research Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Zhao, Shuangyu AU - Zhao S AUID- ORCID: 0000-0003-0454-872X AD - Department of Nutrition, University of California, Davis, CA, United States. FAU - Wang, Jing AU - Wang J AD - Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, United States. AD - Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Gueye-Ndiaye, Seyni AU - Gueye-Ndiaye S AD - Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, United States. AD - Division of Pulmonary and Sleep Medicine, Boston Children's Hospital, Boston, MA, United States. FAU - Li, Xiaoyu AU - Li X AUID- ORCID: 0000-0002-4463-9944 AD - Department of Sociology, Tsinghua University, Beijing, China. FAU - Owens, Judith AU - Owens J AD - Division of Neurology, Boston Children's Hospital, Boston, MA, United States. FAU - Gold, Diane R AU - Gold DR AD - Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States. AD - Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States. FAU - Chen, Jarvis T AU - Chen JT AD - Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Phipatanakul, Wanda AU - Phipatanakul W AUID- ORCID: 0000-0001-8639-0473 AD - Division of Pulmonary and Sleep Medicine, Boston Children's Hospital, Boston, MA, United States. AD - Division of Allergy and Immunology, Boston Children's Hospital, Boston, MA, United States. FAU - Redline, Susan AU - Redline S AUID- ORCID: 0000-0002-6585-1610 AD - Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, United States. LA - eng GR - K24AI106822/National Institute Health/ GR - P30ES000002/National Institute Health/ GR - R35HL135818/National Institute Health/ GR - L40HL165622/National Institute Health/ GR - R01HL137192/National Institute Health/ PT - Journal Article PL - United States TA - Sleep JT - Sleep JID - 7809084 SB - IM CIN - Sleep. 2026 Sep 9;49(9):zsag106. doi: 10.1093/sleep/zsag106. PMID: 41995259 MH - Humans MH - Child MH - Male MH - Female MH - Sleep Duration MH - Cohort Studies MH - *Sleep Wake Disorders/epidemiology MH - *Urban Population/statistics & numerical data MH - Actigraphy MH - Sex Factors MH - Surveys and Questionnaires MH - Sleep Apnea Syndromes/epidemiology MH - *Sex Characteristics OTO - NOTNLM OT - low sleep efficiency OT - pediatric health OT - sex differences OT - short sleep duration OT - sleep-disordered breathing EDAT- 2026/03/02 07:55 MHDA- 2026/07/13 06:32 CRDT- 2026/03/02 05:42 PHST- 2025/07/02 00:00 [received] PHST- 2026/02/05 00:00 [revised] PHST- 2026/02/06 00:00 [accepted] PHST- 2026/07/13 06:32 [medline] PHST- 2026/03/02 07:55 [pubmed] PHST- 2026/03/02 05:42 [entrez] AID - 8503339 [pii] AID - 10.1093/sleep/zsag051 [doi] PST - ppublish SO - Sleep. 2026 Jul 13;49(7):zsag051. doi: 10.1093/sleep/zsag051. PMID- 41766524 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260822 IS - 1463-1326 (Electronic) IS - 1462-8902 (Linking) VI - 28 IP - 5 DP - 2026 May TI - The 1-Hour Plasma Glucose for Early Risk Stratification in Young, Obese Chinese Adults: Implications for Clinical Management. PG - 4276-4285 LID - 10.1111/dom.70620 [doi] AB - AIMS: To evaluate the impact of applying the International Diabetes Federation (IDF) 1-hour plasma glucose (1h-PG) criteria on diagnosing dysglycaemia in young Chinese adults with obesity, and to validate the metabolic basis and diagnostic performance of these criteria in this high-risk population. METHODS: This Cross-Sectional Study Included 2484 Obese Individuals (Aged 18-40 Years, BMI >/= 28 kg/m(2)). Participants underwent a 75-g oral glucose tolerance test (OGTT). Glycaemic status was classified using both traditional American Diabetes Association (ADA) criteria (fasting and 2-hour PG) and the IDF criteria (1h-PG cutoffs: 8.6 mmol/L for intermediate hyperglycaemia, 11.6 mmol/L for diabetes). Insulin sensitivity, secretion and beta-cell function indices were calculated. Reclassification patterns were assessed, and the diagnostic accuracy of the 1h-PG cutoffs was evaluated using receiver operating characteristic (ROC) curve analysis against the ADA criteria. RESULTS: Applying IDF criteria doubled the prevalence of diabetes (from 12.0% to 22.7%) and significantly increased total dysglycaemia. This newly identified dysglycaemic population exhibited an intermediate metabolic phenotype with worsening insulin resistance and impaired early-phase beta-cell function. ROC analysis demonstrated excellent diagnostic accuracy for the IDF diabetes cutoff (11.6 mmol/L; AUC 0.927), which matched the population-optimal cutoff. The cutoff for intermediate hyperglycaemia (8.6 mmol/L) showed high sensitivity (86.8%) for detecting ADA-defined prediabetes. CONCLUSIONS: The IDF 1h-PG criteria uncover a substantial, previously unrecognised burden of dysglycaemia in young Chinese adults with obesity, supported by clear metabolic defects and strong diagnostic performance. These findings support the use of 1h-PG as a practical tool for earlier risk stratification in this vulnerable population. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Yuan, Miaomiao AU - Yuan M AUID- ORCID: 0000-0002-8322-4776 AD - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai, China. FAU - Zhang, Zhenxi AU - Zhang Z AUID- ORCID: 0009-0008-3334-8704 AD - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai, China. FAU - Chen, Yufei AU - Chen Y AUID- ORCID: 0000-0003-4023-2861 AD - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai, China. FAU - Lu, Chenxiao AU - Lu C AUID- ORCID: 0000-0002-1888-7194 AD - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai, China. FAU - Shen, Chongrong AU - Shen C AUID- ORCID: 0000-0001-7164-3888 AD - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai, China. FAU - Zhao, Shaoqian AU - Zhao S AUID- ORCID: 0009-0000-7701-5305 AD - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai, China. FAU - Hong, Jie AU - Hong J AUID- ORCID: 0000-0003-4250-3004 AD - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai, China. LA - eng GR - 25ZR1402341/Natural Science Foundation of Shanghai Municipality/ GR - 25ZR1402352/Natural Science Foundation of Shanghai Municipality/ GR - SHDC12024109/Shanghai Municipal Hospital Development Center/ GR - 82070863/Data Center of Management Science, National Natural Science Foundation of China - Peking University/ GR - 82370845/Data Center of Management Science, National Natural Science Foundation of China - Peking University/ GR - 2025M782163/China Postdoctoral Science Foundation/ GR - 2025ZD0552000/National Health Commission of the People's Republic of China/ PT - Journal Article DEP - 20260302 PL - England TA - Diabetes Obes Metab JT - Diabetes, obesity & metabolism JID - 100883645 RN - 0 (Blood Glucose) RN - Chinese people SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Young Adult MH - *Blood Glucose/metabolism/analysis MH - China/epidemiology MH - Cross-Sectional Studies MH - *Diabetes Mellitus, Type 2/epidemiology/blood/diagnosis MH - Glucose Tolerance Test MH - Insulin Resistance MH - Insulin-Secreting Cells MH - *Obesity/complications/blood MH - *Prediabetic State/diagnosis/blood/epidemiology MH - Risk Assessment MH - Risk Factors MH - East Asian People OTO - NOTNLM OT - 1-hour plasma glucose OT - Chinese population OT - diagnostic criteria OT - insulin resistance OT - international diabetes federation (IDF) OT - obesity OT - oral glucose tolerance test (OGTT) OT - type 2 diabetes OT - young adults OT - beta-Cell function EDAT- 2026/03/02 07:55 MHDA- 2026/04/13 06:32 CRDT- 2026/03/02 04:54 PHST- 2026/02/16 00:00 [revised] PHST- 2026/02/02 00:00 [received] PHST- 2026/02/17 00:00 [accepted] PHST- 2026/04/13 06:32 [medline] PHST- 2026/03/02 07:55 [pubmed] PHST- 2026/03/02 04:54 [entrez] AID - 10.1111/dom.70620 [doi] PST - ppublish SO - Diabetes Obes Metab. 2026 May;28(5):4276-4285. doi: 10.1111/dom.70620. Epub 2026 Mar 2. PMID- 41764983 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260710 IS - 1872-9126 (Electronic) IS - 0003-6870 (Linking) VI - 135 DP - 2026 Sep TI - Generating a representative anthropometric dataset for U.S. children and youth. PG - 104764 LID - S0003-6870(26)00042-6 [pii] LID - 10.1016/j.apergo.2026.104764 [doi] AB - Anthropometric data are widely used in the design of products and environments for children, but the associated publicly available data are sparse and challenging to use. In the United States, the ongoing National Health and Nutrition Examination Survey (NHANES) collects data for both adults and children, including a small number of anthropometric measures. NHANES provides the only available data from which national estimates of U.S. anthropometric variables can be made, but the sampling structure necessitates the use of sample weights to compute estimates. Moreover, a relatively small amount of data is available for children and youth, considering that estimates are often needed for narrow age cohorts. As a result, published estimates are often missing values, particularly in the lower and upper percentiles where many design decisions are made. To address the needs of practitioners, we present and validate a method for synthesizing an unweighted anthropometric dataset for U.S. children and youth ages 2 through 19 years. The method generates continuous models of the distribution of stature, body weight, and body mass index (BMI) by age and sex. Comparison with the published non-parametric quantiles for 2015-2018 shows excellent agreement for all three measures. The resulting synthesized dataset can be used as the foundation for weighting or synthesizing detailed datasets for use in design and provides an avenue for continually updating detailed datasets as NHANES releases new data. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Parkinson, Matthew B AU - Parkinson MB AD - Penn State University, University Park, PA, USA. Electronic address: parkinson@psu.edu. FAU - Reed, Matthew P AU - Reed MP AD - University of Michigan Transportation Research Institute, Ann Arbor, MI, USA. LA - eng PT - Journal Article DEP - 20260228 PL - England TA - Appl Ergon JT - Applied ergonomics JID - 0261412 SB - IM MH - Humans MH - Child MH - United States MH - Adolescent MH - Nutrition Surveys MH - Child, Preschool MH - *Anthropometry/methods MH - Female MH - Body Height MH - Body Mass Index MH - Body Weight MH - Male MH - Young Adult MH - *Datasets as Topic OTO - NOTNLM OT - Anthropometry OT - Children OT - Design OT - Design for human variability OT - NHANES OT - Reweighting OT - Weighting COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/03/02 00:38 MHDA- 2026/04/12 18:29 CRDT- 2026/03/01 18:06 PHST- 2025/05/17 00:00 [received] PHST- 2025/10/21 00:00 [revised] PHST- 2026/02/27 00:00 [accepted] PHST- 2026/04/12 18:29 [medline] PHST- 2026/03/02 00:38 [pubmed] PHST- 2026/03/01 18:06 [entrez] AID - S0003-6870(26)00042-6 [pii] AID - 10.1016/j.apergo.2026.104764 [doi] PST - ppublish SO - Appl Ergon. 2026 Sep;135:104764. doi: 10.1016/j.apergo.2026.104764. Epub 2026 Feb 28. PMID- 41763024 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260710 IS - 1873-7358 (Electronic) IS - 1471-0153 (Linking) VI - 61 DP - 2026 Apr TI - Emotion regulation as a central mechanism linking early maladaptive schemas and maladaptive eating behaviors. PG - 102081 LID - S1471-0153(26)00014-0 [pii] LID - 10.1016/j.eatbeh.2026.102081 [doi] AB - BACKGROUND: Early maladaptive schemas (EMS) are conceptualized as enduring cognitive-emotional vulnerabilities that may predispose individuals to maladaptive eating behaviors. Although associations between EMS and dysregulated eating have been documented, the cognitive-emotional processes underlying these relationships remain insufficiently understood. This study examined whether difficulties in emotion regulation constitute a key psychological pathway linking EMS with maladaptive eating behaviors. METHODS: A large community sample of adults (N = 1500; aged 18-65 years) completed validated self-report measures assessing early maladaptive schemas, difficulties in emotion regulation (DERS), and maladaptive eating behaviors, including emotional overeating (EO), habitual overeating (HO), and dietary restraint (DR). Path analysis examined direct and indirect associations among variables. Network analysis (EBICglasso) was conducted as an exploratory approach to examine cognitive-emotional-behavioral organization. RESULTS: Path analysis indicated that higher levels of EMS were positively associated with greater difficulties in emotion regulation, which were positively related to emotional overeating, habitual overeating, and dietary restraint (all p < .001). Significant indirect associations were observed between EMS and maladaptive eating via difficulties in emotion regulation. Network analysis converged with these findings, identifying difficulties in emotion regulation as the most central node linking cognitive vulnerability with eating-related behaviors, with strongest connections for emotional and habitual overeating. CONCLUSIONS: Across analytical approaches, difficulties in emotion regulation emerged as a central cognitive-emotional process within the examined psychological models associated with links between early maladaptive schemas and maladaptive eating behaviors. These findings underscore the relevance of schema-informed, emotion-focused perspectives for understanding dysregulated eating patterns. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Obara-Golebiowska, Malgorzata AU - Obara-Golebiowska M AD - Department of Clinical, Developmental and Educational Psychology, Faculty of Social Sciences, University of Warmia and Mazury in Olsztyn, ul. Dybowskiego 13, 10-723, Olsztyn, Poland. Electronic address: m.obara-golebiowska@uwm.edu.pl. LA - eng PT - Journal Article DEP - 20260226 PL - United States TA - Eat Behav JT - Eating behaviors JID - 101090048 SB - IM MH - Humans MH - *Emotional Regulation/physiology MH - Female MH - Adult MH - *Feeding Behavior/psychology MH - *Hyperphagia/psychology MH - Middle Aged MH - Adolescent MH - Male MH - Young Adult MH - *Adaptation, Psychological MH - Emotional Eating MH - Aged MH - *Feeding and Eating Disorders/psychology MH - *Emotions OTO - NOTNLM OT - Dietary restraint OT - Early maladaptive schemas OT - Emotion regulation OT - Emotional overeating OT - Habitual overeating OT - Health education and health promotion COIS- Declaration of competing interest The author declares no known competing financial interests or personal relationships that could have influenced the work reported in this paper. EDAT- 2026/03/01 00:35 MHDA- 2026/05/29 15:40 CRDT- 2026/02/28 18:08 PHST- 2025/10/15 00:00 [received] PHST- 2026/02/13 00:00 [revised] PHST- 2026/02/23 00:00 [accepted] PHST- 2026/05/29 15:40 [medline] PHST- 2026/03/01 00:35 [pubmed] PHST- 2026/02/28 18:08 [entrez] AID - S1471-0153(26)00014-0 [pii] AID - 10.1016/j.eatbeh.2026.102081 [doi] PST - ppublish SO - Eat Behav. 2026 Apr;61:102081. doi: 10.1016/j.eatbeh.2026.102081. Epub 2026 Feb 26. PMID- 41762266 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260920 IS - 1436-6215 (Electronic) IS - 1436-6207 (Print) IS - 1436-6207 (Linking) VI - 65 IP - 2 DP - 2026 Feb 28 TI - Dietary behavior and its association with sleep-disordered breathing symptoms in Taiwanese children. LID - 10.1007/s00394-026-03921-z [doi] LID - 73 AB - BACKGROUND: Sleep-disordered breathing (SDB) is highly prevalent in children and is associated with significant cognitive, metabolic, and quality-of-life (QOL) impairments. While obesity is a primary risk factor, the role of specific dietary behaviors as independent, modifiable contributors to SDB symptom severity remains underexplored. PURPOSE: We aimed to (1) examine the association between dietary intake and SDB symptom severity in children, and (2) develop and validate a dietary-based prediction model for moderate-to-severe SDB (msSDB). METHODS: This cross-sectional study analyzed baseline data from 406 children (aged 5.0-12.9 years) with and without SDB symptoms. Caregivers completed a validated 25-item Short Food Frequency Questionnaire to assess dietary intake. SDB symptom severity was measured using the obstructive sleep apnea (OSA)-18 questionnaire, with a total score >/= 60 defining msSDB. Multivariable regression models were used to identify dietary associations. A dietary prediction score was developed and its performance assessed using receiver operating characteristic (ROC) analysis, followed by external validation in a separate cohort (n = 24). RESULTS: Among 406 participants (mean [SD] age, 8.0 [2.1] years; 174 girls [42.9%]), 80 children (19.7%) had msSDB. Higher intake of orange juice, sweets, chocolate, rice, and processed meats was significantly associated with greater total OSA-18 scores and worse subscale scores across domains. Conversely, fish for dinner and savory snacks were inversely associated with symptom burden. A dietary prediction model demonstrated acceptable discrimination for msSDB (area under the ROC curve [AUC] = 0.78; 95% CI, 0.72-0.84). The model showed 79.6% accuracy, 56.3% sensitivity, and 85.3% specificity, with comparable performance in the validation cohort. CONCLUSIONS: Specific dietary behaviors are associated with SDB symptom severity in children. A simple dietary-based score can help identify children at risk for clinically significant SDB, supporting the investigation of dietary interventions in pediatric SDB management. CI - (c) 2026. The Author(s). FAU - Chuang, Hai-Hua AU - Chuang HH AUID- ORCID: 0000-0002-7394-4016 AD - School of Medicine, College of Life Science and Medicine, National Tsing Hua University, Hsinchu, Taiwan. AD - Department of Community Medicine, Cathay General Hospital, Taipei, Taiwan. AD - Department of Industrial Engineering and Management, National Taipei University of Technology, Taipei, Taiwan. FAU - Hu, Ruei-Shan AU - Hu RS AD - Department of Otorhinolaryngology-Head and Neck Surgery, Linkou Main Branch, Chang Gung Memorial Hospital, Taoyuan, Taiwan. AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan. FAU - Lin, Wan-Ni AU - Lin WN AUID- ORCID: 0000-0001-5782-8835 AD - Department of Otorhinolaryngology-Head and Neck Surgery, Linkou Main Branch, Chang Gung Memorial Hospital, Taoyuan, Taiwan. AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan. FAU - Hsin, Li-Jen AU - Hsin LJ AUID- ORCID: 0000-0001-9201-0270 AD - Department of Otorhinolaryngology-Head and Neck Surgery, Linkou Main Branch, Chang Gung Memorial Hospital, Taoyuan, Taiwan. AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan. FAU - Fang, Tuan-Jen AU - Fang TJ AUID- ORCID: 0000-0002-8762-3635 AD - Department of Otorhinolaryngology-Head and Neck Surgery, Linkou Main Branch, Chang Gung Memorial Hospital, Taoyuan, Taiwan. AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan. FAU - Li, Hsueh-Yu AU - Li HY AUID- ORCID: 0000-0002-9016-8098 AD - Department of Otorhinolaryngology-Head and Neck Surgery, Linkou Main Branch, Chang Gung Memorial Hospital, Taoyuan, Taiwan. AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan. FAU - Lee, Li-Ang AU - Lee LA AUID- ORCID: 0000-0001-8414-595X AD - School of Medicine, College of Life Science and Medicine, National Tsing Hua University, Hsinchu, Taiwan. 5738@cgmh.org.tw. AD - Department of Otorhinolaryngology-Head and Neck Surgery, Linkou Main Branch, Chang Gung Memorial Hospital, Taoyuan, Taiwan. 5738@cgmh.org.tw. AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan. 5738@cgmh.org.tw. AD - Department of Otorhinolaryngology-Head and Neck Surgery, Linkou Medical Center, Chang Gung Memorial Hospital, No. 5, Fu-Hsing Street, Gueishan District,, Taoyuan City, 33305, Taiwan. 5738@cgmh.org.tw. LA - eng PT - Journal Article DEP - 20260228 PL - Germany TA - Eur J Nutr JT - European journal of nutrition JID - 100888704 SB - IM MH - Humans MH - Female MH - Male MH - Child MH - Cross-Sectional Studies MH - Taiwan/epidemiology MH - *Sleep Apnea Syndromes/epidemiology MH - Surveys and Questionnaires MH - *Diet/adverse effects MH - Child, Preschool MH - *Feeding Behavior MH - Risk Factors MH - Severity of Illness Index MH - Quality of Life MH - ROC Curve MH - Body Mass Index MH - Prevalence PMC - PMC12950093 OTO - NOTNLM OT - Child OT - Dietary behavior OT - Nutrition OT - Prediction model OT - Quality of life OT - Sleep-disordered breathing COIS- Declarations. Competing interests: The authors declare that they have no conflict of interest. Generative AI and AI-assisted technologies in the writing process: During the preparation of this work, the authors used Gemini 3 Pro in order to perform grammatical and spelling checks. After using this tool, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication. EDAT- 2026/02/28 12:53 MHDA- 2026/03/06 09:07 PMCR- 2026/02/28 CRDT- 2026/02/28 11:24 PHST- 2025/08/29 00:00 [received] PHST- 2026/01/31 00:00 [accepted] PHST- 2026/03/06 09:07 [medline] PHST- 2026/02/28 12:53 [pubmed] PHST- 2026/02/28 11:24 [entrez] PHST- 2026/02/28 00:00 [pmc-release] AID - 10.1007/s00394-026-03921-z [pii] AID - 3921 [pii] AID - 10.1007/s00394-026-03921-z [doi] PST - epublish SO - Eur J Nutr. 2026 Feb 28;65(2):73. doi: 10.1007/s00394-026-03921-z. PMID- 41761480 OWN - NLM STAT- MEDLINE DCOM- 20260725 LR - 20260725 IS - 1875-9270 (Electronic) IS - 1051-9815 (Linking) VI - 84 IP - 4 DP - 2026 Aug TI - Ergonomics knowledge, awareness, and behaviors in a clinical setting: Comparison of individuals with musculoskeletal pain and healthy volunteers. PG - 1016-1023 LID - 10.1177/10519815261424804 [doi] AB - BackgroundErgonomics plays a critical role in musculoskeletal health, yet validated tools such as ROSA may be impractical in high-demand clinical settings. This study compared ergonomics knowledge, awareness, and behaviors between individuals with and without musculoskeletal pain using a concise yes/no-based tool.ObjectiveTo compare ergonomic behaviors, knowledge, and awareness between individuals with and without musculoskeletal pain, and to identify behavioral factors associated with chronic pain.MethodsA cross-sectional study was conducted among adults aged 18-65 in a tertiary healthcare facility. Participants completed a binary-response ergonomics questionnaire assessing posture, workstation adjustment, screen use, and ergonomic equipment habits. Group comparisons used Chi-square and Mann-Whitney U tests (p < 0.05).ResultsAmong 222 participants, chronic pain was significantly associated with female gender, being a housewife, poor posture, lack of chair height adjustment, and reduced screen-time awareness. (p < 0.05) Correct posture, chair adjustment, and screen-time awareness were protective. Elbow support use was associated with lower chronic pain prevalence (p = 0.033).ConclusionsA rapid, binary ergonomics assessment effectively identified behavioral risk factors for chronic musculoskeletal pain. This format may support scalable ergonomic screening in diverse occupational environments. FAU - Kuculmez, Ozlem AU - Kuculmez O AUID- ORCID: 0000-0002-8900-0060 AD - Department of Physical Medicine and Rehabilitation, Baskent University Alanya Hospital, Antalya, Turkey. FAU - Sukun, Abdullah AU - Sukun A AUID- ORCID: 0000-0003-0047-0857 AD - Department of Radiology, Baskent University Alanya Hospital, Antalya, Turkey. LA - eng PT - Journal Article DEP - 20260227 PL - United States TA - Work JT - Work (Reading, Mass.) JID - 9204382 SB - IM MH - Humans MH - Female MH - Adult MH - *Ergonomics/methods/standards MH - *Musculoskeletal Pain/psychology/epidemiology MH - Male MH - Cross-Sectional Studies MH - Middle Aged MH - Surveys and Questionnaires MH - Adolescent MH - Posture MH - *Health Knowledge, Attitudes, Practice MH - Young Adult MH - Aged MH - Working Conditions MH - Risk Factors MH - *Awareness OTO - NOTNLM OT - chronic pain OT - ergonomics OT - musculoskeletal diseases OT - occupational health OT - pain management OT - posture OT - rehabilitation COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/02/28 06:34 MHDA- 2026/07/25 06:36 CRDT- 2026/02/28 00:52 PHST- 2026/07/25 06:36 [medline] PHST- 2026/02/28 06:34 [pubmed] PHST- 2026/02/28 00:52 [entrez] AID - 10.1177/10519815261424804 [doi] PST - ppublish SO - Work. 2026 Aug;84(4):1016-1023. doi: 10.1177/10519815261424804. Epub 2026 Feb 27. PMID- 41760385 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260812 IS - 1473-0480 (Electronic) IS - 0306-3674 (Linking) VI - 60 IP - 8 DP - 2026 Mar 31 TI - Association of leisure-time physical activity at different phases of life with work ability at the end of working life: a Finland-representative 45-year prospective cohort study. PG - 583-589 LID - 10.1136/bjsports-2025-110339 [doi] AB - OBJECTIVE: Leisure-time physical activity (LTPA) has been linked to better work ability in cross-sectional and short-term follow-up studies. Less is known about the effects of long-term habitual LTPA on work ability. We investigated whether differences in lifetime LTPA from adolescence to late adulthood affect work ability at the end of working life. METHODS: In this 45-year observational cohort study involving a nationally representative Finnish sample, we created a latent lifetime LTPA factor from three self-report PA measurements at ages 10-19, 35-44 and 55-64 years. The association between the lifetime LTPA factor and validated Work Ability Index at the end of working life (age 55-64 years) was explored with structural equation modelling-based linear regression analysis. RESULTS: Higher lifetime LTPA was associated with higher work ability at the end of working life (N=2385, 45% males; ss=0.22, SE=0.05, p<0.001) while all three LTPA measurements contributed to the latent LTPA factor (adolescence ss=0.29, SE=0.05; mid-adulthood ss=0.40, SE=0.06; late adulthood LTPA ss=0.59, SE=0.09). In late adulthood (N=815), meeting the 2020 WHO PA guidelines was dose-responsively associated with excellent work ability: OR very active (>2.38 metabolic equivalent of task (MET)-hour/day (>300 min moderate-to-vigorous PA (MVPA) or >150 min vigorous PA (VPA)/week) vs inactive (<1.19 MET-hour/day (<150 min MVPA or <75 min of VPA/week)) = 2.18, 95% CI 1.44 to 3.30; OR active (1.19-2.38 MET-hour/day (150-300 min MVPA or 75-150 min VPA/week)) vs inactive=1.67, 95% CI 1.04 to 2.68. The results remained unchanged after adjustment for covariates sex, educational level and work-related physical strain. CONCLUSIONS: An inactive lifestyle adopted in youth and maintained throughout life may present a significant risk for impaired work ability up to the end of working life. To support workforce productivity, it is essential to implement robust strategies that promote PA, particularly among children and adolescents, but also among working age adults. CI - (c) Author(s) (or their employer(s)) 2026. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Laakso, Perttu AU - Laakso P AUID- ORCID: 0000-0002-6320-8437 AD - University of Jyvaskyla, Faculty of Sport and Health Sciences, Jyvaskyla, Finland perttu.t.t.laakso@jyu.fi. FAU - Ortega, Francisco B AU - Ortega FB AUID- ORCID: 0000-0003-2001-1121 AD - University of Jyvaskyla, Faculty of Sport and Health Sciences, Jyvaskyla, Finland. AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada; and CIBEROBN Physiopathology of Obesity and Nutrition; Granada, Spain, University of Granada, Granada, Spain. FAU - Tolvanen, Asko AU - Tolvanen A AUID- ORCID: 0000-0001-6430-8897 AD - University of Jyvaskyla, Faculty of Education and Psychology, Jyvaskyla, Finland. FAU - Jaakkola, Timo AU - Jaakkola T AUID- ORCID: 0000-0003-1227-2460 AD - University of Jyvaskyla, Faculty of Sport and Health Sciences, Jyvaskyla, Finland. LA - eng PT - Journal Article PT - Observational Study DEP - 20260331 PL - England TA - Br J Sports Med JT - British journal of sports medicine JID - 0432520 SB - IM MH - Humans MH - Finland MH - *Leisure Activities MH - Male MH - Middle Aged MH - Female MH - Prospective Studies MH - *Exercise MH - Adult MH - Child MH - Adolescent MH - Young Adult MH - *Work Capacity Evaluation OTO - NOTNLM OT - Cohort Studies OT - Longitudinal Studies OT - Physical activity OT - Public health COIS- Competing interests: None declared. EDAT- 2026/02/28 00:41 MHDA- 2026/04/01 00:29 CRDT- 2026/02/27 21:42 PHST- 2026/02/12 00:00 [accepted] PHST- 2026/04/01 00:29 [medline] PHST- 2026/02/28 00:41 [pubmed] PHST- 2026/02/27 21:42 [entrez] AID - bjsports-2025-110339 [pii] AID - 10.1136/bjsports-2025-110339 [doi] PST - epublish SO - Br J Sports Med. 2026 Mar 31;60(8):583-589. doi: 10.1136/bjsports-2025-110339. PMID- 41759590 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260718 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 222 DP - 2026 Jul 1 TI - Examining social and family contextual differences between parental feeding practice profiles in UK parents of pre-school children. PG - 108516 LID - S0195-6663(26)00078-4 [pii] LID - 10.1016/j.appet.2026.108516 [doi] AB - Prior research has utilised person-centred approaches to identify parent feeding profiles distinguished by controlling and structure-based practices, but less research has examined autonomy support-based practices, or how social and family contextual factors differ between feeding profiles. This study aimed to identify profiles of parents with similar patterns of feeding practices and to examine whether profiles differ on family contextual factors. In 2022, 989 UK parents of children aged 3-6 years (M = 4.1 years) completed an online survey, which included the Comprehensive Feeding Practices Questionnaire (CFPQ), measuring parental feeding practices, and validated questionnaires capturing family contextual variables. Latent Profile Analysis (LPA) was conducted to identify parent feeding profiles using the CFPQ. A MANCOVA assessed differences in family contextual variables between profiles. LPA identified three profiles based on common model fit indices and theoretical considerations. Profile 1 'moderate control' (25.2%) showed moderate use of controlling practices and low use of structure-based and autonomy support-based practices. Profile 2 'structured and supportive' (29.6%) showed low use of controlling practices and high use of structure-based and autonomy support-based practices. Profile 3 'using everything' (45.2%) showed high use of all three types of feeding practices. Parents in the 'moderate control' profile had significantly lower parental wellbeing and reported more barriers of time and energy for meal planning compared to other profiles. In contrast, parents in the 'structured and supportive' profile had significantly lower household chaos and lower parental stress. Mothers had a higher proportion of membership to the 'structured and supportive' profile (33.9%) compared to other profiles, whereas fathers had a higher membership proportion to the 'using everything' profile (60.9%). Future interventions should be tailored to parent feeding practice profiles and associated family contextual factors. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Povall, Hannah AU - Povall H AD - School of Psychology and Institute of Health and Neurodevelopment, Aston University, Birmingham, B4 7ET, UK; Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, 3220, Australia. Electronic address: hpova16@aston.ac.uk. FAU - Blissett, Jacqueline AU - Blissett J AD - School of Psychology and Institute of Health and Neurodevelopment, Aston University, Birmingham, B4 7ET, UK. FAU - Pickard, Abigail AU - Pickard A AD - School of Psychology and Institute of Health and Neurodevelopment, Aston University, Birmingham, B4 7ET, UK; Department of Clinical Psychology, School of Health in Social Science, University of Edinburgh, UK. FAU - Edwards, Katie L AU - Edwards KL AD - School of Psychology and Institute of Health and Neurodevelopment, Aston University, Birmingham, B4 7ET, UK; School of Psychology, University of Birmingham, UK. FAU - Russell, Catherine G AU - Russell CG AD - Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, 3220, Australia. FAU - Lacy, Kathleen AU - Lacy K AD - Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, 3220, Australia. FAU - Farrow, Claire AU - Farrow C AD - School of Psychology and Institute of Health and Neurodevelopment, Aston University, Birmingham, B4 7ET, UK. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260226 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - Male MH - United Kingdom MH - Child, Preschool MH - Surveys and Questionnaires MH - *Feeding Behavior/psychology MH - *Parents/psychology MH - *Parenting/psychology MH - Child MH - Adult MH - Parent-Child Relations OTO - NOTNLM OT - Feeding goals OT - Latent profile analysis OT - Parent feeding practices OT - Parental stress OT - Parental wellbeing OT - Preschool children COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/02/28 00:41 MHDA- 2026/05/08 00:32 CRDT- 2026/02/27 19:11 PHST- 2025/11/26 00:00 [received] PHST- 2026/02/13 00:00 [revised] PHST- 2026/02/25 00:00 [accepted] PHST- 2026/05/08 00:32 [medline] PHST- 2026/02/28 00:41 [pubmed] PHST- 2026/02/27 19:11 [entrez] AID - S0195-6663(26)00078-4 [pii] AID - 10.1016/j.appet.2026.108516 [doi] PST - ppublish SO - Appetite. 2026 Jul 1;222:108516. doi: 10.1016/j.appet.2026.108516. Epub 2026 Feb 26. PMID- 41758477 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260227 LR - 20260813 IS - 2199-1170 (Print) IS - 2198-9761 (Electronic) IS - 2198-9761 (Linking) VI - 12 IP - 1 DP - 2026 Feb 27 TI - Handgrip Strength Reference Values and Compositional Associations with Physical Activity in Early Childhood: A Large Sample Study of Swedish Preschoolers. LID - 10.1186/s40798-026-00992-4 [doi] LID - 19 AB - BACKGROUND: Muscular strength is a marker of current health and a predictor of long-term health outcomes in young populations, supporting the inclusion of muscle-strengthening activities into current guidelines and recommendations. Over the last decade, muscular strength has been included in several fitness-test batteries in children and adolescents. However, little is known about its relevance and the feasibility of assessing it in preschool children aged 3-5 years. Therefore, in this cross-sectional study, we aimed to generate reference values for handgrip strength in Swedish preschool children and to examine the associations of device-measured movement behaviours (sedentary time [ST], light physical activity [LPA], moderate-to-vigorous physical activity [MVPA], and sleep duration) with handgrip strength using compositional data analysis. RESULTS: A total of 3,218 preschool children (48.53% female) aged 3.0-5.5 years from Sweden were included. Handgrip strength was measured using a validated analog dynamometer following standardized procedures. Movement behaviours were assessed in a subsample of 2,328 children who had both handgrip data and valid accelerometer recordings. Compositional data analysis was used to examine associations between handgrip strength and the 24-hour time-use composition, adjusting for age, sex, body mass index, parental education, and wear time. Age- and sex-specific percentiles for handgrip strength were developed. Boys showed higher handgrip values than girls at all ages (e.g., median increased from 4.08 to 7.42 kg in boys and from 3.45 to 6.87 kg in girls between ages 3 and 5 years). When the proportion of time spent in MVPA increased relative to the other behaviours, handgrip strength rose by + 1.22 kg; the opposite was observed for ST, which related to - 0.84 kg lower handgrip strength. No significant associations were observed for LPA or sleep duration (LPA: beta =-0.48 kg, 95% CI: -1.23, 0.27; sleep: beta = 0.10 kg, 95% CI: -0.37, 0.57). CONCLUSION: This study provides the first normative reference values for handgrip strength from Northern Europe. These values offer a useful reference for screening and contextual interpretation of muscular strength in preschool children. CI - (c) 2026. The Author(s). FAU - Ramirez-Osuna, Ana AU - Ramirez-Osuna A AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. FAU - Campos-Garzon, Pablo AU - Campos-Garzon P AUID- ORCID: 0000-0003-0418-9165 AD - Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. pablo.campos.garzon@ki.se. AD - Faculty of Health Sciences, University of Lethbridge, Lethbridge, AB, Canada. pablo.campos.garzon@ki.se. FAU - Huertas-Delgado, Francisco Javier AU - Huertas-Delgado FJ AD - "La Inmaculada" Teacher Training Centre, University of Granada, Granada, 18013, Spain. FAU - Ahlqvist, Viktor H AU - Ahlqvist VH AD - Department of Biomedicine, Aarhus University, Aarhus, Denmark. AD - Institute of Environmental Medicine, Karolinska Insitutet, Stockholm, Sweden. FAU - Wilen, Charlotte AU - Wilen C AD - Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. FAU - Henriksson, Pontus AU - Henriksson P AD - Department of Medical and Health Sciences, Linkoping University, Linkoping, 581 83, Sweden. FAU - Lundberg, Tommy R AU - Lundberg TR AD - Department of Medical and Health Sciences, Linkoping University, Linkoping, 581 83, Sweden. AD - Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden. FAU - Neovius, Martin AU - Neovius M AD - Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. FAU - Dahlen, Micael AU - Dahlen M AD - Centre for Epidemiology and Community Medicine, Region Stockholm, Stockholm, Sweden. FAU - Berglind, Daniel AU - Berglind D AD - Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. AD - Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden. AD - Centre for Epidemiology and Community Medicine, Region Stockholm, Stockholm, Sweden. LA - eng PT - Journal Article DEP - 20260227 PL - Switzerland TA - Sports Med Open JT - Sports medicine - open JID - 101662568 PMC - PMC12949204 OTO - NOTNLM OT - Muscular strength OT - Physical fitness OT - Preschoolers OT - Reference values COIS- Declarations. Ethics Approval and Consent to Participate: Ethical approval was obtained from the Swedish Ethical Review Authority (Dnr. 2020-03002). The study was conducted in accordance with the ethical standards outlined in the Declaration of Helsinki. Written informed consent was obtained from the parents or legal guardians of all participating children and from participating preschool teachers prior to enrollment in the study. Consent for Publication: Not applicable. Competing Interests: The authors declare that they have no competing interests. EDAT- 2026/02/27 13:05 MHDA- 2026/02/27 13:06 PMCR- 2026/02/27 CRDT- 2026/02/27 11:17 PHST- 2025/08/27 00:00 [received] PHST- 2026/02/17 00:00 [accepted] PHST- 2026/02/27 13:06 [medline] PHST- 2026/02/27 13:05 [pubmed] PHST- 2026/02/27 11:17 [entrez] PHST- 2026/02/27 00:00 [pmc-release] AID - 10.1186/s40798-026-00992-4 [pii] AID - 992 [pii] AID - 10.1186/s40798-026-00992-4 [doi] PST - epublish SO - Sports Med Open. 2026 Feb 27;12(1):19. doi: 10.1186/s40798-026-00992-4. PMID- 41756095 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Construction and application of coordination ability evaluation tool for children aged 4-5.9 years old. PG - 1698428 LID - 10.3389/fpubh.2026.1698428 [doi] LID - 1698428 AB - BACKGROUND: Coordination ability is a critical component influencing children's basic motor skills and participation in physical activities. Positive experiences formed during early movement practice are essential for lifelong health. PURPOSE: This study aimed to scientifically construct a systematic and user-friendly evaluation tool for assessing coordination ability in children aged 4.0-5.9 years, thereby enhancing understanding and promoting targeted development in family and kindergarten activities. METHODS: The evaluation indicators were determined through literature review, structured expert interviews, expert interviews, and the Delphi method. Sixteen cities in Shandong Province were sampled using a stratified random cluster sampling approach. A total of 1,068 valid samples were obtained (530 children aged 4.0-4.9 years and 538 children aged 5.0-5.9 years). Statistical analyses were performed using SPSS 26.0 and AMOS 26.0, including exploratory and confirmatory factor analyses to test model validity. RESULTS: The structural model of coordination ability demonstrated good fit indices. Coordination ability was found to consist of six key dimensions: balance, spatial orientation, rhythm, perceptual judgment, limb coordination, and limb movement range. Evaluation criteria for both 4- and 5-year-old groups were established. Girls exhibited higher overall coordination scores than boys. Boys in the 4-year-old group showed superior perceptual and judgment ability, while boys in the 5-year-old group performed better in perceptual judgment and spatial orientation. CONCLUSION: (1) The constructed evaluation tool accurately reflects children's coordination development. (2) The established single and composite scoring criteria effectively distinguish coordination levels among children aged 4-5.9 years. (3) Gender differences exist, with girls generally outperforming boys, though developmental asynchrony is evident across coordination components. CI - Copyright (c) 2026 Chen and Li. FAU - Chen, Weifu AU - Chen W AD - Department of Physical Education, Beijing Union University, Beijing, China. FAU - Li, Na AU - Li N AD - School of Physical Education, Shandong University of Science and Technology, Qingdao, China. LA - eng PT - Journal Article DEP - 20260211 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Child, Preschool MH - Male MH - *Motor Skills/physiology MH - Female MH - China MH - *Child Development/physiology MH - Delphi Technique PMC - PMC12932535 OTO - NOTNLM OT - assessment criteria OT - basic motor skill OT - coordination ability OT - evaluation index system OT - preschool children COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/27 06:32 MHDA- 2026/03/06 13:45 PMCR- 2026/02/11 CRDT- 2026/02/27 04:56 PHST- 2025/09/03 00:00 [received] PHST- 2025/12/15 00:00 [revised] PHST- 2026/01/19 00:00 [accepted] PHST- 2026/03/06 13:45 [medline] PHST- 2026/02/27 06:32 [pubmed] PHST- 2026/02/27 04:56 [entrez] PHST- 2026/02/11 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1698428 [doi] PST - epublish SO - Front Public Health. 2026 Feb 11;14:1698428. doi: 10.3389/fpubh.2026.1698428. eCollection 2026. PMID- 41755349 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260926 IS - 1879-3479 (Electronic) IS - 0020-7292 (Print) IS - 0020-7292 (Linking) VI - 173 IP - 3 DP - 2026 Jun TI - Artificial intelligence for personalized multiple micronutrient supplementation in maternal health. PG - 1163-1173 LID - 10.1002/ijgo.70911 [doi] AB - Maternal undernutrition and micronutrient deficiencies remain pervasive, contributing to adverse pregnancy outcomes and long-term health risks for mothers and offspring. Multiple micronutrient supplementation (MMS) during pregnancy has demonstrated benefits, including reduced risks of low birth weight, small-for-gestational-age births, and neonatal mortality, when compared with standard iron-folic acid supplementation. Current MMS strategies, however, often follow a standard MMS, overlooking variations in nutritional status, health profiles, and context. Advances in artificial intelligence (AI), particularly deep learning and natural language processing, provide opportunities to strengthen maternal nutrition programs by integrating diverse data sources. Rather than promising fully individualized recommendations, AI could help stratify women by risk of insufficiencies or deficiencies, highlight groups most likely to benefit from additional support, and inform the design of more responsive supplementation strategies during preconception and pregnancy. We outline a conceptual model in which multimodal health data-including electronic health records (EHRs), wearable sensor outputs, nutrition and fertility app logs, genomic markers, and sociodemographic information-are aggregated and analyzed by AI systems to inform personalized MMS plans. The framework introduces the concept of a "nutritional digital twin," a virtual profile of the patient's nutritional and metabolic state. This digital twin can simulate micronutrient needs and predict maternal-fetal outcomes under different supplementation scenarios, enabling clinicians to test scenario-based options (e.g. standard MMS +/- targeted add-ons) for individuals. We describe how deep learning models can identify complex patterns (e.g. diet-genome interactions or behavioral trends) while natural language processing (NLP) algorithms extract clinically relevant insights from unstructured data (such as medical notes or patient queries). In addition, we discuss the role of digital maternal health tools, such as mobile apps and wearable trackers, in supplying real-time data to the AI models and in engaging women to improve adherence to supplementation regimens. Harnessing AI for MMS could transform maternal nutrition care in both high- and low-resource settings. In high-income contexts, rich data (comprehensive EHRs, genetic tests, continuous monitoring devices) could feed advanced predictive models to support risk-stratified care with protocolized supplementation options, under clinical oversight. In low- and middle-income countries, where maternal undernutrition and micronutrient gaps are most prevalent, AI-driven approaches can help stratify risk groups and optimize limited resources. Ubiquitous mobile phone access and digital health tools in many such settings provide avenues for data collection and intervention delivery. We highlight examples where machine learning on population data revealed "hidden hunger" patterns and key predictors of low supplement uptake (e.g. low education, minimal antenatal visits)-insights that policymakers can use to target nutrition programs. A nutritional digital twin could further allow scenario-testing (e.g. predicting the impact of adding a vitamin D supplement for a specific patient) before clinical decisions are made. To realize this vision, the key concerns are ethics, credibility, and fairness. Ethical frameworks must guide development so that sensitive reproductive health data are protected and clinician oversight remains central. The credibility of AI-generated recommendations depends on transparency about the assumptions used to translate nutritional and health data into supplement type and dose, and on prospective validation against maternal and neonatal outcomes. This requires a continuous feedback loop in which recommendations are tested in real-world settings and recalibrated using outcomes data, ensuring that the system learns from observed benefits and harms, rather than relying solely on theoretical modeling. Fairness demands that training data sets represent diverse populations and that solutions are tailored to local contexts to reduce bias and avoid widening disparities. Critically, the approach must be fed by data streams that extend beyond initial demographics and clinical baselines to include biomarkers, adherence patterns, and pregnancy outcomes, so that the models can be refined and dosing rules adjusted over time. If these safeguards are embedded, AI-enhanced personalized MMS can move beyond proof of concept towards a credible, equitable, and empirically grounded contribution to global maternal health. AI-driven personalized nutrition support represents a frontier in obstetric care. By combining clinical knowledge with data-driven intelligence, we can move beyond generalized prenatal supplements towards precision maternal nutrition. The integration of deep learning models and digital health innovations into antenatal care pathways has the potential to better nourish pregnancies, save lives, and ensure healthier futures for mothers and children worldwide. CI - (c) 2026 The Author(s). International Journal of Gynecology & Obstetrics published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics. FAU - Davis Jones, Gabriel AU - Davis Jones G AUID- ORCID: 0000-0003-4070-4814 AD - Oxford Digital Health Labs, Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK. FAU - Papageorghiou, Aris T AU - Papageorghiou AT AD - Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK. AD - Oxford Maternal and Perinatal Health Institute (OMPHI), University of Oxford, Oxford, UK. FAU - Shehata, Hassan AU - Shehata H AD - Royal College of Obstetricians and Gynaecologists, London, UK. FAU - Divakar, Hema AU - Divakar H AD - Divakars Speciality Hospital, Bengaluru, India. FAU - Van der Beek, Eline M AU - Van der Beek EM AD - Department of Pediatrics, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands. AD - Nestle Institute of Health Sciences, Nestle Research, Lausanne, Switzerland. FAU - Senikas, Vyta AU - Senikas V AD - Faculty of Medicine, McGill University, Montreal, Quebec, Canada. FAU - Konje, Justin C AU - Konje JC AD - Feto Maternal Centre, Doha, Qatar. AD - Department of Obstetrics and Gynecology, Weill Cornell Medicine, Doha, Qatar. AD - Department of Health Sciences, University of Leicester, Leicester, UK. FAU - Kihara, Anne-Beatrice AU - Kihara AB AD - Department of Obstetrics & Gynaecology, University of Nairobi, Nairobi, Kenya. FAU - Hod, Moshe AU - Hod M AD - Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel. CN - FIGO Committee on Women's Health and Technology LA - eng PT - Journal Article PT - Review DEP - 20260226 PL - United States TA - Int J Gynaecol Obstet JT - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics JID - 0210174 RN - 0 (Micronutrients) SB - IM MH - Humans MH - Female MH - *Micronutrients/administration & dosage/deficiency MH - Pregnancy MH - *Dietary Supplements MH - *Maternal Health MH - *Artificial Intelligence MH - Pregnancy Complications/prevention & control MH - *Precision Medicine/methods MH - Maternal Nutritional Physiological Phenomena MH - Pregnancy Outcome MH - Nutritional Status MH - Digital Health PMC - PMC13173597 OTO - NOTNLM OT - artificial intelligence OT - digital maternal health OT - low- and middle-income countries OT - maternal nutrition OT - multiple micronutrient supplementation OT - nutritional digital twin OT - personalized nutrition OT - risk stratification COIS- The authors have no conflicts of interest. EDAT- 2026/02/27 06:32 MHDA- 2026/05/14 14:49 PMCR- 2026/05/14 CRDT- 2026/02/27 01:22 PHST- 2026/01/20 00:00 [revised] PHST- 2025/11/19 00:00 [received] PHST- 2026/02/06 00:00 [accepted] PHST- 2026/05/14 14:49 [medline] PHST- 2026/02/27 06:32 [pubmed] PHST- 2026/02/27 01:22 [entrez] PHST- 2026/05/14 00:00 [pmc-release] AID - IJGO70911 [pii] AID - 10.1002/ijgo.70911 [doi] PST - ppublish SO - Int J Gynaecol Obstet. 2026 Jun;173(3):1163-1173. doi: 10.1002/ijgo.70911. Epub 2026 Feb 26. PMID- 41754226 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260926 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 4 DP - 2026 Feb 23 TI - Quality of Anthropometric Data for Child Nutrition Monitoring in India: A Comparative Assessment Using Two Rounds of the National Family Health Survey. LID - 10.3390/nu18040709 [doi] LID - 709 AB - BACKGROUND: High-quality anthropometric data are critical for accurately monitoring child nutritional outcomes and informing policy decisions, yet inconsistencies in measurement and reporting across large-scale surveys continue to challenge data reliability. METHOD: This research assesses the quality of height-for-age (HAZ), weight-for-age (WAZ), and weight-for-height (WHZ) z-scores based on a repeated cross-sectional analysis of two rounds of the National Family Health Survey (NFHS-4, 2015-2016 and NFHS-5, 2019-2021), examining improvements, persistent gaps, and regional disparities. We have used WHO-recommended diagnostics including digit preference, age-heaping, completeness of measurements, biologically implausible values, and distributional properties of z-scores to evaluate the plausibility of anthropometric data and generate state-level rankings to compare transitions across rounds. RESULTS: The results indicate modest national-level improvements in data quality in NFHS-5, particularly reductions in digit preference and implausible values; however, substantial inter-state variation remains, with some states demonstrating clear progress while others continue to exhibit measurement anomalies. The completeness of date of birth improved from 99.0% in NFHS-4 to 99.9% in NFHS-5, while completeness of anthropometric measurements declined from 98.5% to 96.6%. Digit preference for height decreased from 15.2% to 14.4%, and the proportion of biologically implausible HAZ values declined from 3.4% to 2.3%. However, the standard deviation of HAZ increased from 1.77 to 1.85 and that of WHZ from 1.40 to 1.50, indicating persistent measurement variability. Transitions in HAZ rankings further reveal mixed patterns of advancement and stagnation, with regional clustering of improvements more evident in certain parts of the country. Overall, while NFHS-5 reflects progress in anthropometric data quality, key challenges persist related to inconsistent adherence to measurement protocols, variable field performance, and inadequate supervisory oversight. CONCLUSIONS: Strengthening training, standardizing procedures, and reinforcing monitoring mechanisms are essential for achieving more reliable anthropometric data, thereby enhancing the accuracy of child nutrition estimates and supporting more evidence-based policy interventions in India. FAU - Dwivedi, Laxmi Kant AU - Dwivedi LK AUID- ORCID: 0000-0001-9737-2844 AD - Department of Survey Research & Data Analytics, International Institute for Population Sciences, Govandi Station Road, Deonar, Mumbai 400088, India. FAU - Jana, Somnath AU - Jana S AUID- ORCID: 0009-0000-5870-5247 AD - Department of Survey Research & Data Analytics, International Institute for Population Sciences, Govandi Station Road, Deonar, Mumbai 400088, India. FAU - Chauhan, Rupalee Singh AU - Chauhan RS AUID- ORCID: 0009-0009-1627-5985 AD - Department of Survey Research & Data Analytics, International Institute for Population Sciences, Govandi Station Road, Deonar, Mumbai 400088, India. FAU - Bhatia, Mrigesh AU - Bhatia M AUID- ORCID: 0000-0001-9366-142X AD - Department of Health Policy, London School of Economics, London WC2A 2AE, UK. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260223 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - India MH - *Anthropometry/methods MH - Cross-Sectional Studies MH - *Nutrition Surveys MH - Child, Preschool MH - Female MH - *Nutritional Status MH - Male MH - *Child Nutritional Physiological Phenomena MH - *Data Accuracy MH - Child MH - Infant MH - Reproducibility of Results MH - Body Height MH - Body Weight MH - Health Surveys PMC - PMC12943685 OTO - NOTNLM OT - DHS OT - India OT - NFHS OT - anthropometric data quality OT - digit preference OT - stunting OT - underweight OT - wasting COIS- The authors declared that they have no competing interests. EDAT- 2026/02/27 06:32 MHDA- 2026/03/07 01:37 PMCR- 2026/02/23 CRDT- 2026/02/27 01:17 PHST- 2025/12/22 00:00 [received] PHST- 2026/01/16 00:00 [revised] PHST- 2026/01/18 00:00 [accepted] PHST- 2026/03/07 01:37 [medline] PHST- 2026/02/27 06:32 [pubmed] PHST- 2026/02/27 01:17 [entrez] PHST- 2026/02/23 00:00 [pmc-release] AID - nu18040709 [pii] AID - nutrients-18-00709 [pii] AID - 10.3390/nu18040709 [doi] PST - epublish SO - Nutrients. 2026 Feb 23;18(4):709. doi: 10.3390/nu18040709. PMID- 41754221 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 4 DP - 2026 Feb 22 TI - Skipping Breakfast and Lunch, as Well as Reducing Milk and Dairy Intake, Is Associated with Depressive Symptoms in Pregnant Adolescents. LID - 10.3390/nu18040704 [doi] LID - 704 AB - BACKGROUND AND OBJECTIVE: Depression is the most common mental health problem in women during pregnancy, associated with psychological, social, and medical factors characteristic of this stage. However, a lack of knowledge and limited attention to this condition can aggravate its consequences and restrict access to appropriate treatment. This research seeks to fill a gap in the scientific literature by exploring the association between eating habits and dietary diversity with depressive symptomatology in a group with high psychosocial vulnerability: pregnant adolescents. MATERIAL AND METHODS: A cross-sectional analytical study was conducted with a sample of 344 pregnant adolescents attending prenatal care at the National Institute of Perinatology (INPer), a tertiary care center. Non-probabilistic sampling was used for recruitment. Relevant information was collected using a pre-validated structured questionnaire administered via interview. Depressive symptomatology was assessed using the Edinburgh Postnatal Depression Scale (EPDS), with a score of >/=12 considered indicative of a higher risk of depression. Eating habits were evaluated based on meal omission, activities performed during meals, and dietary diversity, comparing them with national recommendations. Food group consumption was assessed using a semi-quantitative Food Frequency Questionnaire (FFQ). Robust variance Poisson regression models were employed to evaluate the independent association between undesirable eating habits, inadequate food group intake, and the presence of depressive symptomatology. RESULTS: A significant association was observed between the presence of depressive symptoms (EPDS >/= 12) and the omission of main meals. Specifically, skipping breakfast was associated with a higher prevalence of EPDS scores >/= 12 (aPR = 1.55; 95% CI: 1.10-2.19; p = 0.013). Similarly, adolescents who skipped lunch showed a higher prevalence of depressive symptomatology compared to those who did not (aPR = 2.02; 95% CI: 1.11-3.68; p = 0.022). Regarding food groups, only insufficient intake of milk and dairy products was significantly associated with the presence of depressive symptoms (aPR: 1.78; 95% CI: 1.16-2.73; p = 0.008). CONCLUSIONS: This cross-sectional study found a significant association between breakfast skipping, distraction while eating, and inadequate dairy intake with a higher prevalence of depressive symptoms in socially vulnerable pregnant adolescents treated at a tertiary care center. However, due to the study's design, causality or the direction of the relationship cannot be established (it could be bidirectional), and it cannot be affirmed that modifying the diet will necessarily reduce depression. Furthermore, the results are not generalizable to all pregnant adolescents, and future research (longitudinal or interventional) is needed to better understand these associations before developing specific dietary interventions. FAU - Samano, Reyna AU - Samano R AUID- ORCID: 0000-0001-5490-1363 AD - Coordinacion de Nutricion y Bioprogramacion, Instituto Nacional de Perinatologia, Secretaria de Salud, Montes Urales 800, Lomas de Virreyes, Alcaldia Miguel Hidalgo, Mexico City 11000, Mexico. FAU - Aguirre-Minutti, Estefania AU - Aguirre-Minutti E AUID- ORCID: 0000-0002-4951-8121 AD - Coordinacion de Nutricion y Bioprogramacion, Instituto Nacional de Perinatologia, Secretaria de Salud, Montes Urales 800, Lomas de Virreyes, Alcaldia Miguel Hidalgo, Mexico City 11000, Mexico. AD - Escuela de Dietetica y Nutricion del ISSSTE, Callejon Via, Av. San Fernando No. 12, San Pedro Apostol, Tlalpan, Mexico City 14070, Mexico. FAU - Martinez-Rojano, Hugo AU - Martinez-Rojano H AD - Seccion de Posgrado e Investigacion de la Escuela Superior de Medicina del Instituto Politecnico Nacional, Plan de San Luis y Diaz Miron s/n, Colonia Casco de Santo Tomas, Alcaldia Miguel Hidalgo, Mexico City 11340, Mexico. FAU - Chico-Barba, Gabriela AU - Chico-Barba G AUID- ORCID: 0000-0002-5741-0241 AD - Coordinacion de Nutricion y Bioprogramacion, Instituto Nacional de Perinatologia, Secretaria de Salud, Montes Urales 800, Lomas de Virreyes, Alcaldia Miguel Hidalgo, Mexico City 11000, Mexico. FAU - Gamboa, Ricardo AU - Gamboa R AUID- ORCID: 0000-0001-9102-4240 AD - Departamento de Fisiologia, Instituto Nacional de Cardiologia "Ignacio Chavez", Mexico City 14080, Mexico. FAU - Hernandez-Chavez, Carmen AU - Hernandez-Chavez C AD - Departamento de Neurobiologia del Desarrollo, Instituto Nacional de Perinatologia, Secretaria de Salud, Montes Urales 800, Lomas de Virreyes, Alcaldia Miguel Hidalgo, Mexico City 11000, Mexico. FAU - Mendoza-Flores, Maria Eugenia AU - Mendoza-Flores ME AD - Coordinacion de Nutricion y Bioprogramacion, Instituto Nacional de Perinatologia, Secretaria de Salud, Montes Urales 800, Lomas de Virreyes, Alcaldia Miguel Hidalgo, Mexico City 11000, Mexico. FAU - Gonzalez-Medina, Erika AU - Gonzalez-Medina E AD - Escuela de Dietetica y Nutricion del ISSSTE, Callejon Via, Av. San Fernando No. 12, San Pedro Apostol, Tlalpan, Mexico City 14070, Mexico. FAU - Perez-Romero, Primavera AU - Perez-Romero P AD - Escuela de Dietetica y Nutricion del ISSSTE, Callejon Via, Av. San Fernando No. 12, San Pedro Apostol, Tlalpan, Mexico City 14070, Mexico. LA - eng GR - SECTEI/147/2024, registration 3602c24./Secretariat of Education, Science, Technology and Innovation of Mexico City (SECTEI) 2024/ PT - Journal Article DEP - 20260222 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Adolescent MH - Pregnancy MH - Cross-Sectional Studies MH - *Depression/epidemiology/etiology/psychology MH - *Breakfast/psychology MH - Animals MH - *Feeding Behavior/psychology MH - *Dairy Products MH - *Lunch/psychology MH - Milk MH - Intermittent Fasting MH - *Diet PMC - PMC12943198 OTO - NOTNLM OT - adolescent pregnancy OT - depression OT - depressive symptoms OT - eating habits OT - mental health OT - skipping breakfast COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/27 06:32 MHDA- 2026/03/08 01:38 PMCR- 2026/02/22 CRDT- 2026/02/27 01:17 PHST- 2026/01/19 00:00 [received] PHST- 2026/02/14 00:00 [revised] PHST- 2026/02/17 00:00 [accepted] PHST- 2026/03/08 01:38 [medline] PHST- 2026/02/27 06:32 [pubmed] PHST- 2026/02/27 01:17 [entrez] PHST- 2026/02/22 00:00 [pmc-release] AID - nu18040704 [pii] AID - nutrients-18-00704 [pii] AID - 10.3390/nu18040704 [doi] PST - epublish SO - Nutrients. 2026 Feb 22;18(4):704. doi: 10.3390/nu18040704. PMID- 41754177 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 4 DP - 2026 Feb 17 TI - A Maturation-Aware Machine Learning Framework for Screening the Nutritional Status of Adolescents. LID - 10.3390/nu18040660 [doi] LID - 660 AB - Background: Malnutrition in adolescents remains a significant public health issue worldwide, with undernutrition and overweight often coexisting. Accurate nutritional screening during adolescence is complicated by variability in biological maturation and class imbalance, particularly among underweight adolescents. Objective: This study aims to develop and validate machine learning models for classifying the nutritional status of adolescents, accounting for class imbalance and biological maturation, and to evaluate model stability and variable importance at different stages of peak height velocity (PHV). Methods: In this cross-sectional study, 4232 adolescents aged 11 to 18 years were recruited from nine educational institutions in Tunisia. Their nutritional status was classified according to the International Obesity Task Force (IOTF) BMI thresholds into three categories: underweight (14.4%), normal weight (68.3%), and overweight (17.2%). Ten anthropometric, behavioral, and maturation-related predictors were analyzed. Six supervised machine learning algorithms were evaluated using a 70/30 stratified split between training and test sets, with five-fold cross-validation. Class imbalance was addressed by ROSE combined with cost-sensitive learning. Model performance was assessed using accuracy, Cohen's kappa coefficient, macro F1 score, sensitivity, specificity, and AUC. Results: The cost-sensitive Random Forest (RF) model achieved the best overall performance, with an accuracy of 0.830, a macro F1 score of 0.767, a macro-AUC of 0.921, and a macro- sensitivity of 0.743. The class-specific sensitivities were 0.70 (underweight), 0.91 (normal weight), and 0.62 (overweight), with no major misclassification between the extreme categories. Performance remained stable across the different maturation phases (accuracy from 0.823 to 0.839), with optimal discrimination in the pre-PHV (macro-AUC = 0.936; sensitivity for underweight = 0.82) and post-PHV (macro-AUC = 0.931) periods. Body mass was the main predictor (importance = 1.00), followed by waist circumference (0.34-0.53). The importance of age for classifying underweight increased significantly from the pre-PHV (0.10) to the post-PHV (0.75) period. A two-stage hierarchical model further improved underweight detection (stage 1 AUC = 0.911; sensitivity = 0.732). Conclusions: A cost-sensitive RF model, combined with ROSE, provides robust classification of adolescents' nutritional status maturation, significantly improving underweight detection while preserving overall accuracy. This approach is particularly well-suited to public health screening in schools as a first-stage assessment that requires clinical confirmation and promotes a maturation-aware interpretation of nutritional risk among adolescents. FAU - Ghouili, Hatem AU - Ghouili H AD - Research Unit: Sports Science, Health and Movement, High Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef 7100, Tunisia. FAU - Farhani, Zouhaier AU - Farhani Z AD - Research Unit: Sports Science, Health and Movement, High Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef 7100, Tunisia. FAU - Yousfi, Narimen AU - Yousfi N AUID- ORCID: 0000-0002-2507-0553 AD - Research Unit: Sports Science, Health and Movement, High Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef 7100, Tunisia. FAU - Ceylan, Halil Ibrahim AU - Ceylan HI AUID- ORCID: 0009-0005-2214-4667 AD - Physical Education and Sports Teaching Department, Faculty of Sports Sciences, Ataturk University, Erzurum 25240, Turkiye. FAU - Dridi, Amel AU - Dridi A AD - Research Unit: Sports Science, Health and Movement, High Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef 7100, Tunisia. FAU - de Giorgio, Andrea AU - de Giorgio A AUID- ORCID: 0000-0001-6064-5634 AD - Artificial Engineering, 80121 Naples, Italy. FAU - Bragazzi, Nicola Luigi AU - Bragazzi NL AUID- ORCID: 0000-0001-8409-868X AD - Laboratory for Industrial and Applied Mathematics (LIAM), Department of Mathematics and Statistics, York University, Toronto, ON M3J 1P3, Canada. AD - Human Nutrition Unit (HNU), Department of Food and Drugs, University of Parma, 43121 Parma, Italy. AD - Department of Clinical Pharmacy, Saarland University, 66123 Saarbrucken, Germany. FAU - Guelmami, Noomen AU - Guelmami N AUID- ORCID: 0000-0002-4959-9726 AD - Research Unit: Sports Science, Health and Movement, High Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef 7100, Tunisia. FAU - Dergaa, Ismail AU - Dergaa I AUID- ORCID: 0000-0001-8091-1856 AD - Higher Institute of Sport and Physical Education of Ksar Said, University of Manouba, Manouba 2010, Tunisia. AD - Physical Activity Research Unit, Sport and Health (UR18JS01), National Observatory of Sports, Tunis 1003, Tunisia. FAU - Bouassida, Anissa AU - Bouassida A AD - Research Unit: Sports Science, Health and Movement, High Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef 7100, Tunisia. LA - eng PT - Journal Article DEP - 20260217 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Nutritional Status MH - Adolescent MH - Child MH - Cross-Sectional Studies MH - *Machine Learning MH - Random Forest MH - Female MH - Male MH - *Malnutrition/diagnosis MH - Classification Algorithms MH - Tunisia MH - Thinness/diagnosis MH - *Nutrition Assessment MH - Predictive Learning Models MH - *Mass Screening/methods MH - Body Mass Index MH - Overweight/diagnosis PMC - PMC12943452 OTO - NOTNLM OT - adolescent nutrition OT - biological maturation OT - class imbalance OT - machine learning OT - peak height velocity OT - random forest OT - underweight COIS- A.d.G. is the owner and CEO of Artificial Engineering. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/27 06:31 MHDA- 2026/03/06 09:08 PMCR- 2026/02/17 CRDT- 2026/02/27 01:17 PHST- 2025/12/27 00:00 [received] PHST- 2026/02/08 00:00 [revised] PHST- 2026/02/12 00:00 [accepted] PHST- 2026/03/06 09:08 [medline] PHST- 2026/02/27 06:31 [pubmed] PHST- 2026/02/27 01:17 [entrez] PHST- 2026/02/17 00:00 [pmc-release] AID - nu18040660 [pii] AID - nutrients-18-00660 [pii] AID - 10.3390/nu18040660 [doi] PST - epublish SO - Nutrients. 2026 Feb 17;18(4):660. doi: 10.3390/nu18040660. PMID- 41754147 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 4 DP - 2026 Feb 14 TI - Associations Between Restrained, Emotional, and External Eating Behaviors and Obesity Among Saudi Adults: A Cross-Sectional Study. LID - 10.3390/nu18040631 [doi] LID - 631 AB - BACKGROUND AND AIM: Obesity has reached alarming levels globally and across the Middle East. In Saudi Arabia, approximately one-third of Saudi adults have obesity, representing a major public health concern. Understanding behavioral factors underlying obesity is essential; therefore, this study aimed to investigate the association between eating styles and obesity indicators among Saudi adults and to examine gender differences in these associations. METHODS: This cross-sectional study included 997 adult (405 males and 592 females) aged >/= 18 years residing in Saudi Arabia. Data were collected using a self-administered questionnaire covering sociodemographic characteristics, anthropometric measures, health status. Eating behaviors were assessed using the validated Dutch Eating Behavior Questionnaire (DEBQ), which measures restrained, emotional, and external eating styles. Regression models were used to examine gender differences in mean eating style scores and to assess associations between eating styles, categorical BMI, and body fatness. RESULTS: The mean age of participants was 37.05 +/- 13.39 years. Significant gender differences were observed in BMI, body fatness, and physical activity levels. Females demonstrated higher restrained eating scores compared with males (beta = -0.14; 95% CI: -0.24, -0.04; p = 0.008). Participants with obesity exhibited higher emotional eating scores, while external eating was more prevalent among underweight participants. Body fatness was significantly associated with emotional and external eating but not restrained eating. CONCLUSIONS: BMI status appears to be associated with specific eating styles, particularly unhealthy eating behaviors. These findings highlight the importance of behavioral-focused nutritional interventions that support eating regulation rather than emphasizing weight loss alone. FAU - Almaghrabi, Merfat Abdulrahman AU - Almaghrabi MA AUID- ORCID: 0000-0001-5521-4987 AD - Food and Nutrition Department, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia. FAU - Bawajeeh, Areej AU - Bawajeeh A AD - Food and Nutrition Department, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia. FAU - Shatwan, Israa M AU - Shatwan IM AUID- ORCID: 0000-0003-0222-9135 AD - Food and Nutrition Department, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia. FAU - Malibary, Manal AU - Malibary M AUID- ORCID: 0000-0003-3611-9583 AD - Food and Nutrition Department, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia. AD - Food, Nutrition and Lifestyle Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 3270, Saudi Arabia. FAU - Alzhrani, Shahad AU - Alzhrani S AD - Food and Nutrition Department, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia. FAU - Alamoudi, Nouf AU - Alamoudi N AD - Food and Nutrition Department, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia. FAU - Almadani, Jena AU - Almadani J AD - Food and Nutrition Department, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia. FAU - Albar, Salwa AU - Albar S AUID- ORCID: 0000-0002-7559-6908 AD - Food and Nutrition Department, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia. LA - eng GR - IPP: 1438-253-2025/Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah, Saudi Arabia/ PT - Journal Article DEP - 20260214 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Cross-Sectional Studies MH - Saudi Arabia/epidemiology MH - Female MH - *Obesity/psychology/epidemiology MH - Adult MH - *Feeding Behavior/psychology MH - Middle Aged MH - Emotional Eating MH - Body Mass Index MH - *Emotions MH - Surveys and Questionnaires MH - Young Adult MH - Sex Factors MH - Adolescent PMC - PMC12942921 OTO - NOTNLM OT - Saudi Arabia OT - emotional eating OT - external eating OT - obesity OT - restrained eating COIS- The authors declare no conflicts of interest. EDAT- 2026/02/27 06:32 MHDA- 2026/03/07 16:14 PMCR- 2026/02/14 CRDT- 2026/02/27 01:17 PHST- 2026/01/06 00:00 [received] PHST- 2026/02/07 00:00 [revised] PHST- 2026/02/09 00:00 [accepted] PHST- 2026/03/07 16:14 [medline] PHST- 2026/02/27 06:32 [pubmed] PHST- 2026/02/27 01:17 [entrez] PHST- 2026/02/14 00:00 [pmc-release] AID - nu18040631 [pii] AID - nutrients-18-00631 [pii] AID - 10.3390/nu18040631 [doi] PST - epublish SO - Nutrients. 2026 Feb 14;18(4):631. doi: 10.3390/nu18040631. PMID- 41749663 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260227 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 2 DP - 2026 Feb 23 TI - Associations Between Body Mass Index, Movement Behaviors, Motor Skills, Inhibition and Visuospatial Working Memory in Preschool Children: A Cross-Sectional Study Based on WHO References. LID - 10.3390/children13020306 [doi] LID - 306 AB - BACKGROUND: Early childhood represents a key stage for the development of movement behaviors (MB), motor skills (MS), and executive functions (EF). Body Mass Index (BMI), defined according to World Health Organization (WHO) references, may influence these domains early in life. In this context, this cross-sectional observational study aimed to examine the associations between BMI and 24-h MB, MS, and EF in Tunisian preschool children aged 4 to 5 years. METHODS: This cross-sectional observational study included 112 Tunisian children aged 4 to 5 years (50 boys, 62 girls), recruited from kindergartens in urban and rural areas. Anthropometric measurements were used to calculate age-specific BMI z-scores and classify children into three BMI categories: below normal, normal, and above normal. Twenty-four-hour MB physical activity (PA), sedentary behavior (SB), and sleep were objectively assessed using accelerometry over five consecutive days. EF (inhibition and working memory) were assessed using standardized cognitive tests, gross MS were evaluated using the Supine Timed Up and Go test (functional mobility), One-Leg Standing Balance test (postural steadiness), Hand Grip Dynamometer (upper body strength), and Standing Long Jump (lower body strength), and fine MS were assessed using the 9-Hole Pegboard Test (dexterity). All tools are validated and standardized for children. RESULTS: Significant differences between BMI categories were observed for anthropometric variables (p < 0.05). In contrast, no significant differences were found for 24-h MB, adherence to recommendations, EF, and MS (p > 0.05). Only Sleep duration showed a difference significantly between BMI < normal and BMI > normal (p = 0.022). CONCLUSIONS: In Tunisian preschool children, weight status is primarily associated with differences in physical growth, with no marked relationship to MB, EF, or MS. These findings highlight the importance of universal preventive interventions, particularly focusing on growth monitoring, starting in early childhood. These results should be interpreted with caution and highlight the need for further studies on larger populations to better understand the relationships between BMI, PA, and development in young children. FAU - Ltifi, Mohamed Amine AU - Ltifi MA AUID- ORCID: 0000-0003-1784-6961 AD - Higher Institute of Sport and Physical Education of Gafsa, University of Gafsa, Gafsa 2112, Tunisia. AD - Research Laboratory (LR23JS01) "Sport Performance, Health & Society", Higher Institute of Sport and Physical Education of Ksar Said, University of Manouba, Tunis 2010, Tunisia. FAU - Nejah, Kacem AU - Nejah K AD - LR15JS01 EM2S, Education, Motricity, Sport and Health, Higher Institute of Sport and Physical Education, University of Sfax, Sfax 3029, Tunisia. FAU - Hammami, Fadhel AU - Hammami F AD - Research Laboratory (LR23JS01) "Sport Performance, Health & Society", Higher Institute of Sport and Physical Education of Ksar Said, University of Manouba, Tunis 2010, Tunisia. FAU - Bica, Monica Delia AU - Bica MD AUID- ORCID: 0000-0002-7767-4762 AD - Faculty of Medical and Behavioral Sciences, "Constantin Brancusi" University of Targu-Jiu, 210185 Targu Jiu, Romania. FAU - Zwierzchowska, Anna AU - Zwierzchowska A AUID- ORCID: 0000-0002-4284-8697 AD - Department of Physical Education and Adapted Physical Activity, The Jerzy Kukuczka Academy of Physical Education in Katowice, 40-959 Katowice, Poland. FAU - Wilk, Michal AU - Wilk M AUID- ORCID: 0000-0001-5799-6337 AD - Institute of Sport Sciences, The Jerzy Kukuczka Academy of Physical Education, 40-065 Katowice, Poland. FAU - Alexe, Dan Iulian AU - Alexe DI AUID- ORCID: 0000-0002-6396-761X AD - Department of Physical and Occupational Therapy, "Vasile Alecsandri" University of Bacau, 600115 Bacau, Romania. FAU - Chelly, Mohamed-Souhaiel AU - Chelly MS AUID- ORCID: 0000-0002-0713-1308 AD - Research Laboratory (LR23JS01) "Sport Performance, Health & Society", Higher Institute of Sport and Physical Education of Ksar Said, University of Manouba, Tunis 2010, Tunisia. LA - eng PT - Journal Article DEP - 20260223 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12939077 OTO - NOTNLM OT - 24-h movement behaviors OT - anthropometric characteristics OT - body mass index (BMI) OT - child development OT - executive functions OT - motor skills OT - preschool children COIS- The authors declare no conflicts of interest. EDAT- 2026/02/27 06:32 MHDA- 2026/02/27 06:33 PMCR- 2026/02/23 CRDT- 2026/02/27 01:02 PHST- 2026/01/18 00:00 [received] PHST- 2026/02/17 00:00 [revised] PHST- 2026/02/20 00:00 [accepted] PHST- 2026/02/27 06:33 [medline] PHST- 2026/02/27 06:32 [pubmed] PHST- 2026/02/27 01:02 [entrez] PHST- 2026/02/23 00:00 [pmc-release] AID - children13020306 [pii] AID - children-13-00306 [pii] AID - 10.3390/children13020306 [doi] PST - epublish SO - Children (Basel). 2026 Feb 23;13(2):306. doi: 10.3390/children13020306. PMID- 41749655 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260227 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 2 DP - 2026 Feb 21 TI - Obesity-Related Changes in Growth Hormone Stimulation Test Performance Under Pediatric Growth Hormone Deficiency. LID - 10.3390/children13020299 [doi] LID - 299 AB - BACKGROUND/OBJECTIVES: The objective of this study is to determine the extent to which obesity alters the diagnostic reliability of the clonidine stimulation test (CST) for growth hormone deficiency (GHD) and whether incorporating insulin-like growth factor 1 (IGF-1) and the annual growth velocity standard deviation score (GV SDS) improves diagnostic precision. METHODS: This retrospective study included 101 children evaluated for short stature using the clonidine stimulation test, with serum GH concentrations determined by a two-site, solid-phase, enzyme-labeled chemiluminescent immunometric assay (Immulite 2000 XPi, Siemens Healthcare Diagnostics, USA). Diagnostic performance was compared between overweight/obese (n = 47) and normal-weight (n = 54) groups. A two-step algorithm was evaluated: Step 1 applied a GH peak threshold of <5 ng/mL; Step 2 integrated IGF-1 SDS < -1.5 and annual GV SDS < -2.0 among children with subthreshold GH responses. RESULTS: The median GH peak was significantly lower in overweight/obese children (4.5 [IQR 2.0-7.4] vs. 8.2 [5.1-11.5] ng/mL; p = 0.043). Although sensitivity remained comparable (82.6% vs. 90.5%; p = 0.666), elevated BMI markedly reduced specificity (50.0% vs. 84.8%; p = 0.008) and overall accuracy (66.0% vs. 87.0%; p = 0.017). Overweight/obese children demonstrated a higher proportion of false-positive CST results than non-obese children (25.5% vs. 9.3%). Among obese children with a GH peak of <5 ng/mL (n = 31), Step 2, which integrates IGF-1 and GV, improved specificity from 50% to 75% and the positive predictive value from 61.3% to 84.2%, correctly reclassifying 9 of 12 children without GHD who would otherwise have been misdiagnosed based on CST alone. CONCLUSIONS: Fixed GH cutoffs may lead to the misclassification of GHD in children with elevated BMI. Obesity significantly reduces the specificity and diagnostic accuracy of CST, increasing false-positive results. A two-step approach integrating IGF-1 and GV improves diagnostic precision and helps to differentiate true GHD from obesity-related GH suppression. FAU - Ozdemir Dilek, Semine AU - Ozdemir Dilek S AUID- ORCID: 0000-0003-2100-0301 AD - Department of Pediatric Endocrinology, University of Health Sciences, Adana City Training and Research Hospital, Adana 01370, Turkey. FAU - Ozguc Comlek, Fatma AU - Ozguc Comlek F AUID- ORCID: 0000-0002-2752-3480 AD - Department of Pediatric Endocrinology, Medical Faculty, Selcuk University, Konya 42250, Turkey. LA - eng PT - Journal Article DEP - 20260221 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12939514 OTO - NOTNLM OT - Growth velocity OT - Insulin-like growth factor 1 OT - clonidine stimulation test OT - growth hormone deficiency OT - obesity OT - overweight COIS- The authors declare no conflicts of interest. EDAT- 2026/02/27 06:31 MHDA- 2026/02/27 06:32 PMCR- 2026/02/21 CRDT- 2026/02/27 01:02 PHST- 2026/01/24 00:00 [received] PHST- 2026/02/16 00:00 [revised] PHST- 2026/02/19 00:00 [accepted] PHST- 2026/02/27 06:32 [medline] PHST- 2026/02/27 06:31 [pubmed] PHST- 2026/02/27 01:02 [entrez] PHST- 2026/02/21 00:00 [pmc-release] AID - children13020299 [pii] AID - children-13-00299 [pii] AID - 10.3390/children13020299 [doi] PST - epublish SO - Children (Basel). 2026 Feb 21;13(2):299. doi: 10.3390/children13020299. PMID- 41749568 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260227 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 2 DP - 2026 Jan 31 TI - Cross-Sectional Assessment of Sleep-Disordered Breathing Prevalence in Pediatric Population with Obesity. LID - 10.3390/children13020212 [doi] LID - 212 AB - BACKGROUND: Childhood obesity is a growing public health concern globally and is associated with a wide spectrum of comorbidities, including sleep-disordered breathing (SDB). SDB remains under-recognized in pediatric population with obesity, particularly in Middle Eastern settings, despite its significant impact on cognitive, behavioral, and metabolic health. OBJECTIVES: To assess the prevalence of SDB among children with obesity aged 6-12 years attending King Faisal University polyclinics in Saudi Arabia and to identify key demographic and anthropometric predictors, with particular emphasis on the mediating role of neck circumference. METHODS: A cross-sectional study was conducted involving 130 children with obesity aged 6-12 years. Data collection included sociodemographic characteristics, anthropometric measurements (BMI percentile, neck and waist circumference), and screening for SDB using the validated Arabic version of the Pediatric Sleep Questionnaire Sleep-Related Breathing Disorder (PSQ-SRBD) scale. Logistic regression and mediation analyses were performed to examine associations and pathways between obesity parameters and SDB risk. RESULTS: Of the 130 participants, 37.7% screened positive for SDB risk. SDB prevalence was higher among males and older children. Neck circumference and BMI percentile were independently associated with SDB risk, with neck circumference mediating the relationship between BMI and SDB. The mediation model indicated that increased BMI contributes to SDB risk both directly and indirectly through increased neck circumference. CONCLUSIONS: SDB is highly prevalent among obese Saudi children, and neck circumference is a significant mediator of risk. Incorporating SDB screening and neck circumference measurements into routine pediatric obesity care can facilitate early detection and management. These findings support the need for integrated, multidisciplinary approaches to improve pediatric health outcomes. FAU - Alarfaj, Abdullah Ahmed AU - Alarfaj AA AD - Department of Surgery, College of Medicine, King Faisal University, Al-Ahsa 31982, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260131 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12939691 OTO - NOTNLM OT - Saudi Arabia OT - childhood obesity OT - neck circumference OT - pediatric OT - sleep-disordered breathing COIS- The author declares no conflicts of interest. EDAT- 2026/02/27 06:31 MHDA- 2026/02/27 06:32 PMCR- 2026/01/31 CRDT- 2026/02/27 01:02 PHST- 2025/12/05 00:00 [received] PHST- 2026/01/23 00:00 [revised] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/02/27 06:32 [medline] PHST- 2026/02/27 06:31 [pubmed] PHST- 2026/02/27 01:02 [entrez] PHST- 2026/01/31 00:00 [pmc-release] AID - children13020212 [pii] AID - children-13-00212 [pii] AID - 10.3390/children13020212 [doi] PST - epublish SO - Children (Basel). 2026 Jan 31;13(2):212. doi: 10.3390/children13020212. PMID- 41749303 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Feb 26 TI - Behaviour patterns on social media and their associations with cognitive, social and emotional skills in university students. LID - 10.1186/s40359-026-04109-0 [doi] LID - 622 AB - BACKGROUND: Research on digital behaviour has largely centred on aggregated screen-time metrics, which offer limited insight into how distinct patterns of engagement within social media environments relate to psychosocial competencies. Life skills-encompassing cognitive, social and emotional domains-are fundamental to adaptive functioning in young adults, yet the behavioural features of online interaction that align with these capacities remain insufficiently characterised. METHODS: A cross-sectional study was carried out with 420 university students aged 18-25. Participants completed a questionnaire assessing instrumental, passive and reactive social media behaviours, alongside a validated measure of life skills. Analytical procedures included descriptive statistics, Spearman correlations, exploratory factor analysis and structural equation modelling. Reliability coefficients were estimated from the present sample, and model fit indices were examined to assess structural coherence. RESULTS: Instrumental engagement displayed small positive associations with cognitive and social life skills. Passive browsing and reactive interaction showed small negative associations with emotional and social skills. Although modest in magnitude, these associations displayed a stable configuration across the analytical models, suggesting that behavioural differentiation within social media use aligns with distinct life-skill profiles. CONCLUSIONS: The study contributes to a more nuanced understanding of digital engagement by shifting the analytical focus from global usage frequency to behaviour-specific patterns. Instrumental, goal-directed use aligned with more adaptive skill configurations, whereas passive and reactive tendencies were associated with less favourable profiles. The cross-sectional design and the demographic composition of the sample constrain generalisability, underscoring the need for longitudinal and diverse population studies. The findings reinforce the relevance of intentional and reflective digital practices within university settings, where online interaction is embedded in daily life. FAU - Guerrero-Gutierrez, Nestor AU - Guerrero-Gutierrez N AD - Universidad de Pamplona, Facultad de Salud, Pamplona, 543050, Colombia. FAU - Rojas-Cadena, Silvia Juliana AU - Rojas-Cadena SJ AD - Universidad de Pamplona, Facultad de Salud, Pamplona, 543050, Colombia. FAU - Ibanez-Casadiegos, Eliana AU - Ibanez-Casadiegos E AD - Universidad de Pamplona, Facultad de Salud, Pamplona, 543050, Colombia. FAU - Rozo-Sanchez, Astrid AU - Rozo-Sanchez A AD - Universidad de Pamplona, Facultad de Salud, Pamplona, 543050, Colombia. FAU - Cepeda-Pineda, Daniel AU - Cepeda-Pineda D AD - Universidad de La Sabana, Facultad de Ciencias del Comportamiento, Chia, Cundinamarca, 111321, Colombia. FAU - Carrillo-Sierra, Sandra-Milena AU - Carrillo-Sierra SM AD - Universidad de Pamplona, Facultad de Salud, Pamplona, 543050, Colombia. sandra.carrillo3@unipamplona.edu.co. FAU - Bermudez, Valmore AU - Bermudez V AD - Universidad Simon Bolivar, Centro de Investigaciones en Ciencias de La Vida, Barranquilla, 080001, Colombia. valmore.bermudez@unisimon.edu.co. FAU - Contreras-Velasquez, Julio Cesar AU - Contreras-Velasquez JC AD - Universidad de la Costa, Departamento de Productividad e Innovacion, Barranquilla, Atlantico, 080001, Colombia. FAU - Gomez-Charris, Yulineth AU - Gomez-Charris Y AD - Universidad de la Costa, Departamento de Productividad e Innovacion, Barranquilla, Atlantico, 080001, Colombia. FAU - Rivera-Porras, Diego AU - Rivera-Porras D AD - Universidad de la Costa, Departamento de Productividad e Innovacion, Barranquilla, Atlantico, 080001, Colombia. drivera23@cuc.edu.co. LA - eng PT - Journal Article DEP - 20260226 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - *Students/psychology MH - Male MH - *Social Media/statistics & numerical data MH - Universities MH - Young Adult MH - Adolescent MH - Adult MH - *Social Skills MH - *Emotions MH - *Cognition MH - Media Exposure MH - *Social Behavior MH - Social Interaction MH - Digital Media PMC - PMC13126760 OTO - NOTNLM OT - Digital behaviour OT - Individual differences OT - Life skills OT - Online engagement OT - Social media OT - Young adults COIS- Declarations. Ethics approval and consent to participate: Informed consent was obtained from all participants involved in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/27 00:33 MHDA- 2026/06/27 06:45 PMCR- 2026/02/26 CRDT- 2026/02/26 23:50 PHST- 2025/11/04 00:00 [received] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/06/27 06:45 [medline] PHST- 2026/02/27 00:33 [pubmed] PHST- 2026/02/26 23:50 [entrez] PHST- 2026/02/26 00:00 [pmc-release] AID - 10.1186/s40359-026-04109-0 [pii] AID - 4109 [pii] AID - 10.1186/s40359-026-04109-0 [doi] PST - epublish SO - BMC Psychol. 2026 Feb 26;14(1):622. doi: 10.1186/s40359-026-04109-0. PMID- 41748531 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2026 Feb 27 TI - Food brand recall and its association with diet-related behaviours among Thai children. PG - e63 LID - 10.1017/S1368980026102183 [doi] LID - e63 AB - OBJECTIVE: Food brand marketing is one of the techniques used by the food industry to create positive images and enhance brand recall among children. The objectives of this study were to assess food and beverage brand recall and to examine the sociodemographic characteristics associated with food brand recall, as well as the purchasing and consumption of branded foods among Thai children. DESIGN: Cross-sectional analysis of secondary data from the 2024 Monitoring on Food and Beverage Marketing to Children in Thailand survey. A validated and reliable questionnaire was used for data collection. Descriptive statistics were used to summarise sociodemographic characteristics, food and beverage brand recall, and purchasing behaviours. Associations between brand recall and purchasing behaviours were examined using multivariable logistic regression models. SETTING: Eleven provinces across Thailand. PARTICIPANTS: A total of 2113 children aged 10-18 years. RESULTS: Nearly 40 % of children recalled sweetened beverage brands, while 35 % recalled snack brands. Food and beverage brand recall was statistically associated with purchasing and consumption of branded foods across several product categories after adjustment for sociodemographic characteristics. CONCLUSIONS: Food and beverage brand recall was commonly reported among Thai children and showed statistically significant associations with purchasing and consumption behaviours. These findings contribute to the evidence base on food marketing exposure among children in Thailand. FAU - Jindarattanaporn, Nongnuch AU - Jindarattanaporn N AUID- ORCID: 0000-0002-6241-7851 AD - Institute for Population and Social Research, https://ror.org/01znkr924Mahidol University, Thailand. FAU - Chuenchom, Salakjit AU - Chuenchom S AD - Institute for Population and Social Research, https://ror.org/01znkr924Mahidol University, Thailand. LA - eng PT - Journal Article DEP - 20260227 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Child MH - Thailand MH - Cross-Sectional Studies MH - Female MH - Male MH - Adolescent MH - *Mental Recall MH - *Diet/psychology/statistics & numerical data MH - *Marketing MH - *Feeding Behavior/psychology MH - Beverages MH - Surveys and Questionnaires MH - Snacks MH - *Food MH - Food Preferences/psychology PMC - PMC13087976 OTO - NOTNLM OT - Brand recall OT - Children OT - Consumption OT - Food OT - Purchasing COIS- The authors report there are no competing interests to declare. The authors report there are no competing interests to declare. EDAT- 2026/02/27 00:33 MHDA- 2026/03/31 06:59 PMCR- 2026/02/27 CRDT- 2026/02/26 23:12 PHST- 2026/03/31 06:59 [medline] PHST- 2026/02/27 00:33 [pubmed] PHST- 2026/02/26 23:12 [entrez] PHST- 2026/02/27 00:00 [pmc-release] AID - S1368980026102183 [pii] AID - 10.1017/S1368980026102183 [doi] PST - epublish SO - Public Health Nutr. 2026 Feb 27;29(1):e63. doi: 10.1017/S1368980026102183. PMID- 41748431 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260709 IS - 1440-0960 (Electronic) IS - 0004-8380 (Linking) VI - 67 IP - 4 DP - 2026 Jun TI - Minimising Late Scar Widening of the Dorsal Trunk in Young Adults: A Prospective Study of the Dermo-Epidermally Anchored Trapezoidal Excision (DATE) Technique. PG - e226-e231 LID - 10.1111/ajd.70067 [doi] AB - INTRODUCTION: Late scar widening is a common but underrecognized complication of dorsal fusiform excisions, especially in young adults with high dermal elasticity and physically active lifestyles. OBJECTIVE: To evaluate the effectiveness of Dermo-epidermally Anchored Trapezoidal Excision (DATE), a technique designed to minimise long-term scar diastasis. METHODS: This prospective, two-arm, open-label study was conducted between January 2015 and February 2022 at the "Celio" Military Hospital, Rome, Italy. Healthy adults aged 18-31 years undergoing elective dorsal trunk excisions were allocated by surgical scheduling to either standard fusiform excision (control) or the DATE technique (experimental). Scar widening was evaluated at 12 months using the Scar Diastasis Index (SDI). RESULTS: A total of 273 patients were enrolled (126 control, 147 experimental), with comparable baseline characteristics. At 12 months, the DATE arm showed a significantly lower mean SDI (22.10 +/- 7.05) compared to the control group (63.35 +/- 11.52; p < 0.001). Patients in the experimental group experienced temporary swelling along the scar line or small stitch marks, but these resolved within a few weeks. CONCLUSIONS: DATE is a safe, reproducible, and cost-effective technique. In young adults with high aesthetic expectations, it led to significantly narrower scars than the standard fusiform approach and may represent the preferred option for dorsal excisions. CI - (c) 2026 Australasian College of Dermatologists. FAU - Astorino, Stefano AU - Astorino S AUID- ORCID: 0000-0003-1836-2512 AD - Department of Medicine, Dermatology and STDs Unit, "Celio" Military Hospital, Rome, Italy. FAU - Di Nunno, Donato AU - Di Nunno D AUID- ORCID: 0000-0002-7327-6580 AD - Department of Medicine, Dermatology and STDs Unit, "Celio" Military Hospital, Rome, Italy. FAU - Mucciante, Lohengrin AU - Mucciante L AUID- ORCID: 0009-0001-5182-3205 AD - Pharmacy Service, "Celio" Military Hospital, Rome, Italy. FAU - Occhicone, Francesca AU - Occhicone F AD - Clinical Pathology Unit, San Camillo Forlanini Hospital, Rome, Italy. FAU - Troiani, Giorgio AU - Troiani G AUID- ORCID: 0000-0003-3891-306X AD - Department of Medicine, Dermatology and STDs Unit, "Celio" Military Hospital, Rome, Italy. FAU - Laghi, Alessandro AU - Laghi A AUID- ORCID: 0000-0002-5170-488X AD - Department of Medicine, Dermatology and STDs Unit, "Celio" Military Hospital, Rome, Italy. LA - eng PT - Journal Article DEP - 20260226 PL - Australia TA - Australas J Dermatol JT - The Australasian journal of dermatology JID - 0135232 SB - IM MH - Humans MH - Adult MH - Prospective Studies MH - Young Adult MH - Female MH - Adolescent MH - *Cicatrix/prevention & control/etiology MH - Male MH - Torso MH - *Postoperative Complications/prevention & control MH - *Dermatologic Surgical Procedures/methods/adverse effects OTO - NOTNLM OT - aesthetic OT - diastasis OT - fusiform excision OT - scar OT - trapezoidal excision EDAT- 2026/02/27 00:33 MHDA- 2026/06/01 08:04 CRDT- 2026/02/26 22:03 PHST- 2026/02/05 00:00 [revised] PHST- 2025/12/07 00:00 [received] PHST- 2026/02/09 00:00 [accepted] PHST- 2026/06/01 08:04 [medline] PHST- 2026/02/27 00:33 [pubmed] PHST- 2026/02/26 22:03 [entrez] AID - 10.1111/ajd.70067 [doi] PST - ppublish SO - Australas J Dermatol. 2026 Jun;67(4):e226-e231. doi: 10.1111/ajd.70067. Epub 2026 Feb 26. PMID- 41747357 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260709 IS - 1476-5616 (Electronic) IS - 0033-3506 (Linking) VI - 253 DP - 2026 Apr TI - The relationship between intimate partner violence and body mass index based on a Chinese national survey. PG - 106093 LID - S0033-3506(25)00539-6 [pii] LID - 10.1016/j.puhe.2025.106093 [doi] AB - OBJECTIVES: The objective of this study was to explore the association between intimate partner violence (IPV) and body mass index (BMI), and to further investigate how the severity and specific subtypes of IPV are associated with BMI outcomes. STUDY DESIGN: A national, cross-sectional survey was conducted. METHODS: Data from 23,469 adults in the 2023 Psychology and Behavior Investigation of Chinese Residents were analyzed to examine associations between IPV and BMI. IPV severity and subtypes were assessed via a validated five-item scale, and BMI was categorized according to Chinese standards. Multinomial logistic regression and restricted cubic spline models evaluated both linear and nonlinear relationships, with subgroup analyses exploring variations by sociodemographic and psychosocial factors. RESULTS: Among 23,469 participants, IPV exposure showed a significant inverted U-shaped relationship with BMI, peaking at a score of 7.41; mild to moderate IPV exposure was associated with a higher risk of overweight/obesity, while severe IPV was associated with underweight. Subtype analyses revealed that sexual violence and controlling behaviours were correlated with underweight, whereas emotional and verbal abuse were associated with overweight and obesity. CONCLUSIONS: The study demonstrated that the severity and subtype of intimate partner violence (IPV) exposure have distinct effects on body mass index (BMI) outcomes, underscoring the need for integrating IPV screening into weight-related assessments and for developing targeted, context-specific public health interventions. CI - Copyright (c) 2026 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved. FAU - Wang, Ling AU - Wang L AD - School of Nursing, Fudan University, Shanghai, China. FAU - Xiao, Runxi AU - Xiao R AD - School of Nursing, Fudan University, Shanghai, China. FAU - Wu, Yibo AU - Wu Y AD - Department of Nursing, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Hangzhou, China. FAU - Cao, Jiacheng AU - Cao J AD - School of Nursing, Fudan University, Shanghai, China. FAU - Weng, Yajuan AU - Weng Y AD - School of Nursing, Fudan University, Shanghai, China. FAU - Qian, Huijuan AU - Qian H AD - Nursing Department, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Zhang, Qi AU - Zhang Q AD - School of Nursing, Fudan University, Shanghai, China. FAU - Yun, Bei AU - Yun B AD - School of Nursing, Fudan University, Shanghai, China. FAU - Cai, Tingting AU - Cai T AD - School of Nursing, Fudan University, Shanghai, China. FAU - Wu, Fulei AU - Wu F AD - School of Nursing, Fudan University, Shanghai, China. Electronic address: wufulei@fudan.edu.cn. FAU - Yuan, Changrong AU - Yuan C AD - School of Nursing, Fudan University, Shanghai, China. Electronic address: yuancr@fudan.edu.cn. LA - eng PT - Journal Article DEP - 20260225 PL - Netherlands TA - Public Health JT - Public health JID - 0376507 SB - IM MH - Humans MH - Female MH - *Body Mass Index MH - *Intimate Partner Violence/statistics & numerical data MH - Cross-Sectional Studies MH - China/epidemiology MH - Adult MH - Male MH - Middle Aged MH - Surveys and Questionnaires MH - Risk Factors MH - Obesity/epidemiology MH - Young Adult MH - Overweight/epidemiology MH - Adolescent OTO - NOTNLM OT - Association OT - Body mass index OT - Cross-sectional study OT - Intimate partner violence COIS- Declaration of competing interests The authors declare no competing interests. EDAT- 2026/02/27 00:33 MHDA- 2026/03/20 00:59 CRDT- 2026/02/26 18:02 PHST- 2025/07/01 00:00 [received] PHST- 2025/11/29 00:00 [revised] PHST- 2025/12/03 00:00 [accepted] PHST- 2026/03/20 00:59 [medline] PHST- 2026/02/27 00:33 [pubmed] PHST- 2026/02/26 18:02 [entrez] AID - S0033-3506(25)00539-6 [pii] AID - 10.1016/j.puhe.2025.106093 [doi] PST - ppublish SO - Public Health. 2026 Apr;253:106093. doi: 10.1016/j.puhe.2025.106093. Epub 2026 Feb 25. PMID- 41747238 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260226 LR - 20260813 IS - 2561-6722 (Electronic) IS - 2561-6722 (Linking) VI - 9 DP - 2026 Feb 26 TI - Using Wearable Video Cameras to Assess Screen Use Contexts in Preschool-Aged Children: Pilot Observational Study. PG - e85215 LID - 10.2196/85215 [doi] LID - e85215 AB - BACKGROUND: Wearable video cameras may offer a feasible approach to assess the contexts of screen use (eg, screen content and co-use) among preschool-aged children. OBJECTIVE: The objective of this study was to assess the contexts of screen use among preschool-aged children using wearable video cameras. METHODS: Children aged 2 to 5 years from Melbourne, Australia, wore a video camera for 1 day in the home environment during May 2023. One researcher manually coded video footage second by second; 15% was double coded for reliability. Coding included device type, screen activity, screen content classified using Common Sense Media ratings, streaming service, setting, social interaction, screen multitasking, and concurrent behaviors. RESULTS: A total of 37,944 seconds (10.5 hours) of video camera footage from 8 children were identified and coded as screen use, equating to 21.8% (37,944/174,290) of total camera wear time (range 0.3%-74.0%). Screen use was predominately characterized by program viewing (n=37,461, 98.7% seconds) on televisions (n=34,192, 90.1% seconds) in the lounge room (n=33,710, 88.8% seconds). Programs scored low for educational value (mean 1.7, SD 1.4 of 5 stars), and approximately one-third (3/9, 33.3%) of programs were classified as appropriate for an age older than that of the children in this sample. Screen multitasking was rare (n=46, 0.1% of seconds), and coviewing occurred in approximately one-third of all screen use (n=11,010, 29%). CONCLUSIONS: Contexts considered beneficial for development (eg, educational and age-appropriate content) were infrequently observed. This suggests that interventions to equip parents with practical strategies to identify genuine educational content and recognize and avoid age-inappropriate content are warranted. However, our small sample size limits generalizability. CI - (c) Amanda Machell, Katherine Downing, Simone J J M Verswijveren, Kylie D Hesketh. Originally published in JMIR Pediatrics and Parenting (https://pediatrics.jmir.org). FAU - Machell, Amanda AU - Machell A AUID- ORCID: 0000-0002-9058-3435 AD - Institute for Physical Activity and Nutrition (IPAN), Deakin University, 1 Gheringhap Street, Geelong, 3220, Australia, 61 392446613. FAU - Downing, Katherine AU - Downing K AUID- ORCID: 0000-0002-6552-8506 AD - Institute for Physical Activity and Nutrition (IPAN), Deakin University, 1 Gheringhap Street, Geelong, 3220, Australia, 61 392446613. FAU - Verswijveren, Simone J J M AU - Verswijveren SJJM AUID- ORCID: 0000-0002-7709-7416 AD - Institute for Physical Activity and Nutrition (IPAN), Deakin University, 1 Gheringhap Street, Geelong, 3220, Australia, 61 392446613. FAU - Hesketh, Kylie D AU - Hesketh KD AUID- ORCID: 0000-0002-2702-7110 AD - Institute for Physical Activity and Nutrition (IPAN), Deakin University, 1 Gheringhap Street, Geelong, 3220, Australia, 61 392446613. LA - eng PT - Journal Article DEP - 20260226 PL - Canada TA - JMIR Pediatr Parent JT - JMIR pediatrics and parenting JID - 101727244 PMC - PMC12945350 OTO - NOTNLM OT - early childhood OT - screen time OT - smartphone OT - tablet OT - television COIS- Conflicts of Interest: None declared. EDAT- 2026/02/26 19:29 MHDA- 2026/02/26 19:30 PMCR- 2026/02/26 CRDT- 2026/02/26 16:45 PHST- 2025/10/03 00:00 [received] PHST- 2025/12/24 00:00 [accepted] PHST- 2026/02/26 19:30 [medline] PHST- 2026/02/26 19:29 [pubmed] PHST- 2026/02/26 16:45 [entrez] PHST- 2026/02/26 00:00 [pmc-release] AID - v9i1e85215 [pii] AID - 85215 [pii] AID - 10.2196/85215 [doi] PST - epublish SO - JMIR Pediatr Parent. 2026 Feb 26;9:e85215. doi: 10.2196/85215. PMID- 41743552 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Machine learning-based prediction of IVF/ICSI outcomes in male factor infertility highlighting couple-level BMI. PG - 1772106 LID - 10.3389/fendo.2026.1772106 [doi] LID - 1772106 AB - BACKGROUND: Most clinical prediction models for assisted reproductive technology focus primarily on female ovarian reserve markers and often under-represent male factors and the metabolic status of both partners. Additionally, traditional parametric models may have limited ability to capture nonlinear patterns within reproductive data. This study aimed to develop and validate a machine learning (ML)-based model to predict clinical pregnancy outcomes in couples with male factor infertility undergoing IVF/ICSI, and to explore model interpretability using Shapley Additive exPlanations (SHAP). METHODS: This retrospective study analyzed 2,565 couples undergoing their first IVF/ICSI cycle for male factor infertility at Shanghai First Maternity and Infant Hospital between 2019 and 2025. The cohort was partitioned according to embryo transfer date, with the first 70% of cases assigned to the training set and the remaining 30% reserved as an temporal internal validation set. Feature selection was conducted using LASSO regression within the training set. Seven ML models, including LightGBM and Logistic Regression, were developed and optimized through 5-fold cross-validation. Model performance was evaluated using the area under the curve (AUC), accuracy, Brier score, and decision curve analysis. SHAP was employed to provide a visual interpretation of the optimal model. RESULTS: Five predictors were selected in the training set: female BMI, male BMI, basal FSH, AMH, and female age. In the temporal validation set, all models demonstrated comparable discriminative performance (AUC range: 0.840-0.857). LightGBM achieved an AUC of 0.857 (95% CI: 0.830-0.882), with an accuracy of 0.775 and specificity of 0.909. DeLong tests indicated no statistically significant differences in AUC between LightGBM and Random Forest (P = 0.918), XGBoost (P = 0.985), or logistic regression (P = 0.067). Based on its overall stability across discrimination, calibration (Brier score = 0.145), and clinical utility, LightGBM was selected for interpretability analysis. CONCLUSIONS: A LightGBM-based prediction model demonstrated reasonable performance for predicting IVF/ICSI outcomes in couples with male factor infertility. Within this dataset, couple-level metabolic features were strongly associated with model predictions alongside traditional ovarian reserve markers. These findings reflect predictive associations rather than causal effects and suggest that metabolic characteristics may warrant consideration in risk stratification and counseling. Prospective studies are needed to determine whether targeted interventions can improve clinical outcomes. CI - Copyright (c) 2026 Li, Gao and Li. FAU - Li, Hu AU - Li H AD - Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China. FAU - Gao, Jie AU - Gao J AD - Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China. FAU - Li, Yiran AU - Li Y AD - Centre for Assisted Reproduction, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China. LA - eng PT - Journal Article DEP - 20260210 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - Male MH - Female MH - Retrospective Studies MH - *Fertilization in Vitro/methods MH - Pregnancy MH - *Sperm Injections, Intracytoplasmic MH - *Machine Learning MH - *Infertility, Male/therapy MH - Predictive Learning Models MH - *Body Mass Index MH - Adult MH - Pregnancy Outcome MH - Boosting Machine Learning Algorithms MH - Pregnancy Rate MH - Prediction Algorithms MH - Classification Algorithms PMC - PMC12929144 OTO - NOTNLM OT - body mass index OT - clinical pregnancy OT - lightGBM OT - machine learning OT - male infertility COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/26 15:21 MHDA- 2026/03/07 01:37 PMCR- 2026/02/10 CRDT- 2026/02/26 04:40 PHST- 2025/12/20 00:00 [received] PHST- 2026/01/23 00:00 [revised] PHST- 2026/01/26 00:00 [accepted] PHST- 2026/03/07 01:37 [medline] PHST- 2026/02/26 15:21 [pubmed] PHST- 2026/02/26 04:40 [entrez] PHST- 2026/02/10 00:00 [pmc-release] AID - 10.3389/fendo.2026.1772106 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Feb 10;17:1772106. doi: 10.3389/fendo.2026.1772106. eCollection 2026. PMID- 41743257 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260226 LR - 20260813 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - Validation of the behavioral regulation in cycling to and from school scale among students from Germany. PG - 1701435 LID - 10.3389/fspor.2026.1701435 [doi] LID - 1701435 AB - The prevalence of total physical activity among children and adolescents in Germany is reported to be low (D-) according to the country-specific Report Card from 2022. One potential strategy to increase physical activity is the promotion of cycling to and from school. To foster a more self-determined form of motivation among students, we developed a promising intervention grounded in the self-determination theory, as demonstrated in previous research. Here, we aimed to validate the "German behavioral regulation in cycling to and from school scale" focusing on construct and criterion validity as well as reliability to create a robust measurement instrument. Conducted in Southern Germany in 2021, this study involved 112 girls, 124 boys, and three students identifying as diverse (13.5 +/- 1.1 years) who attended a (sub)urban secondary school that provided an intermediate and/or high educational level. We were unable to validate the original first-order six-factor model. Instead, we successfully validated a newly developed first-order three-factor model, which demonstrated a good global model fit (GFI: 0.997, SRMR: 0.0313), measurement model invariance across gender (GFI: 0.986-0.994, SRMR: 0.0426-0.0596), and internal consistency (alpha: 0.846-0.927). For this new scale, both convergent (AVE: 0.582-0.762) and discriminant validity [Formula: see text] were established. Concurrent criterion validity was found acceptable by the correlation between the mean value for each of the three newly developed factors and the frequency of cycling to school (R = 0.616) as well as the increased likelihood of cycling to school based on mean levels of autonomous (p < 0.001; OR = 2.5 [CI 95 for OR: 1.9, 3.3]) and controlled (p < 0.001; OR = 1.7 [CI 95 for OR: 1.3, 2.4]) motivation. Consequently, we concluded that our study provides a valid and reliable scale measuring behavioral regulation in cycling to and from school, by applying a first-order three-factor model. Furthermore, researchers and practitioners, such as (physical education) teachers, could use this scale to assess the motivation for cycling to and from school in order to implement and evaluate contextual and tailored interventions. CI - (c) 2026 Schonbach, Marques, Peralta, Kleszczewska, Dzielska, Burgueno, Huertas-Delgado and Demetriou. FAU - Schonbach, Dorothea M I AU - Schonbach DMI AD - Department of Rehabilitation and Sports Medicine, Hannover Medical School, Hanover, Germany. AD - TUM School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Marques, Adilson AU - Marques A AD - Centro Interdisciplinar de Performance Humana (CIPER), Faculdade de Motricidade Humana, Universidade de Lisboa, Lisbon, Portugal. AD - Nucleo de Investigacion en Ciencias del Movimiento, Universidad Arturo Prat, Iquique, Chile. FAU - Peralta, Miguel AU - Peralta M AD - Centro Interdisciplinar de Performance Humana (CIPER), Faculdade de Motricidade Humana, Universidade de Lisboa, Lisbon, Portugal. FAU - Kleszczewska, Dorota AU - Kleszczewska D AD - Department of Health Sociology, Education and Medical Communication, Institute of Mother and Child, Warsaw, Poland. FAU - Dzielska, Anna AU - Dzielska A AD - Department of Child and Adolescent Health, Institute of Mother and Child, Warsaw, Poland. FAU - Burgueno, Rafael AU - Burgueno R AD - Department of Didactics of Languages, Arts and Sport, University of Malaga, Malaga, Spain. FAU - Huertas-Delgado, Francisco Javier AU - Huertas-Delgado FJ AD - Teacher Training Centre La Inmaculada, University of Granada, Granada, Spain. FAU - Demetriou, Yolanda AU - Demetriou Y AD - Institute of Sports Science, University of Tubingen, Tubingen, Germany. LA - eng PT - Journal Article DEP - 20260211 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC12931929 OTO - NOTNLM OT - autonomous motivation OT - bicycling to school OT - measurement instrument OT - organismic integration theory OT - self-determination theory COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/26 13:40 MHDA- 2026/02/26 13:41 PMCR- 2026/02/11 CRDT- 2026/02/26 04:37 PHST- 2025/09/08 00:00 [received] PHST- 2026/01/07 00:00 [revised] PHST- 2026/01/14 00:00 [accepted] PHST- 2026/02/26 13:41 [medline] PHST- 2026/02/26 13:40 [pubmed] PHST- 2026/02/26 04:37 [entrez] PHST- 2026/02/11 00:00 [pmc-release] AID - 10.3389/fspor.2026.1701435 [doi] PST - epublish SO - Front Sports Act Living. 2026 Feb 11;8:1701435. doi: 10.3389/fspor.2026.1701435. eCollection 2026. PMID- 41742298 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 1756-0500 (Electronic) IS - 1756-0500 (Linking) VI - 19 IP - 1 DP - 2026 Feb 25 TI - Patient-reported satisfaction after ultrasound-assisted liposuction with infra-areolar excision for gynecomastia: a retrospective cross-sectional from Palestine. LID - 10.1186/s13104-026-07735-4 [doi] LID - 154 AB - BACKGROUND: Gynecomastia can have significant psychosocial impacts. Ultrasound-assisted liposuction (UAL) combined with glandular excision has emerged as a preferred technique for contour correction with minimal scarring. This study evaluates surgical outcomes and patient satisfaction following UAL with glandular excision. METHODOLOGY: This was a retrospective cross-sectional study of male patients who underwent bilateral gynecomastia correction using ultrasound-assisted liposuction with infra-areolar excision between September 2022 and June 2024 in Palestine. Clinical and perioperative variables were extracted from medical records, and outcomes were supplemented with patient-reported satisfaction using the validated Arabic BODY-Q chest and nipple modules collected via an online follow-up questionnaire. Nonparametric group comparisons, Spearman correlation, and multivariable linear regression were used to identify predictors of satisfaction (SPSS v21). RESULTS: A total of 133 patients were included (median age 28 years; median BMI 26 kg/m(2)). Most cases were physiological and primarily Simon grade IIa/IIb. The median aspirated fat volume was 350 Ml. Postoperative complications were generally infrequent; the most common were asymmetry, redundant skin, hematoma, and contour irregularity, and 12% of patients underwent revision surgery. Overall satisfaction was high in both BODY-Q domains. Chest satisfaction decreased with increasing gynecomastia grade and was independently lower in patients with contour irregularity, undesirable scars, redundant skin, and recurrence. Nipple satisfaction was independently lower with contour irregularity, undesirable scars, redundant skin, and nipple-areola complex adherence. Chest and nipple satisfaction scores were positively correlated. CONCLUSION: Ultrasound-assisted liposuction with infra-areolar excision achieved high patient-reported satisfaction with a low-to-moderate complication profile in this Palestinian cohort. Satisfaction was driven primarily by postoperative aesthetic factors-particularly contour quality, scarring, redundant skin, and recurrence, highlighting key targets for surgical optimization and patient counselling. CI - (c) 2026. The Author(s). FAU - Aljamal, Mahdi AU - Aljamal M AUID- ORCID: 0000-0003-1809-6138 AD - Department of Surgery, Faculty of Medicine and Health Sciences, Arab American University, Jenin, Palestine. Mahdi.aljamal@aaup.edu. FAU - Shakhshir, Ali AU - Shakhshir A AUID- ORCID: 0000-0003-4138-8497 AD - Department of Medicine, Faculty of Medicine and Health Sciences, Arab American University, Jenin, Palestine. shakhshirali@gmail.com. FAU - Sulaiman, Amro J A AU - Sulaiman AJA AUID- ORCID: 0009-0003-1856-3856 AD - Faculty of Medicine and Health Sciences, Arab American University, Jenin, Palestine. FAU - Zeidalkilani, Mohammed A AU - Zeidalkilani MA AUID- ORCID: 0009-0006-0335-1860 AD - Faculty of Medicine and Health Sciences, Arab American University, Jenin, Palestine. LA - eng PT - Journal Article DEP - 20260225 PL - England TA - BMC Res Notes JT - BMC research notes JID - 101462768 SB - IM MH - Humans MH - Male MH - *Gynecomastia/surgery MH - Retrospective Studies MH - *Patient Satisfaction/statistics & numerical data MH - *Lipectomy/methods MH - Cross-Sectional Studies MH - Adult MH - Young Adult MH - Adolescent MH - Patient Reported Outcome Measures MH - Middle Aged PMC - PMC13040969 OTO - NOTNLM OT - Body-Q OT - Cross-sectional retrospective study OT - Glandularexcision OT - Gynecomastia OT - Palestine OT - Satisfaction OT - Ultrasound-assisted liposuction (UAL) COIS- Declarations. Ethics approval and consent to participate: The research protocol was approved by the IRB committee of the Arab American University (Reference number: J-2025/A/7/N). The study adhered to the ethical principles outlined in the Declaration of Helsinki. Before data collection, the researchers provided a verbal explanation of the study's purpose to each potential participant, and informed consent was obtained from all subjects. Participants were also informed of their right to withdraw from the study at any time without facing any consequences. Consent of publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/26 15:23 MHDA- 2026/04/01 07:04 PMCR- 2026/02/25 CRDT- 2026/02/26 00:04 PHST- 2025/08/30 00:00 [received] PHST- 2026/02/12 00:00 [accepted] PHST- 2026/04/01 07:04 [medline] PHST- 2026/02/26 15:23 [pubmed] PHST- 2026/02/26 00:04 [entrez] PHST- 2026/02/25 00:00 [pmc-release] AID - 10.1186/s13104-026-07735-4 [pii] AID - 7735 [pii] AID - 10.1186/s13104-026-07735-4 [doi] PST - epublish SO - BMC Res Notes. 2026 Feb 25;19(1):154. doi: 10.1186/s13104-026-07735-4. PMID- 41742260 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 25 IP - 1 DP - 2026 Feb 25 TI - Agreement Of A 24-hour food record and relative validity of a food frequency questionnaire compared with urinary biomarkers of sodium, potassium, and protein intake. LID - 10.1186/s12937-026-01298-7 [doi] LID - 32 AB - BACKGROUND: Dietary assessment methods such as food frequency questionnaires (FFQs) and 24-hour food records (24hFRs) are widely used in population-based studies due to their feasibility and relatively low cost. However, these self-reported methods are subject to measurement errors, including recall bias and misreporting, which may vary across individuals and seasons. In contrast, 24-hour urinary excretion (24UE) of sodium, potassium, and nitrogen is considered a more objective biomarker of intake and is often used as a reference method in validation studies. AIM: This study aimed to evaluate the agreement of a 24-hour food record (24hFR) and the relative validity of a food frequency questionnaire (FFQ) against recovery urinary biomarkers of sodium, potassium, and urea-derived protein intake. METHOD: This observational, cross-sectional validation study included a total of 37 healthy adult women aged 18-44 years. Information on participants' sociodemographic characteristics, dietary habits, and physical activity levels was collected, and anthropometric measurements were performed by the researcher. In addition, 24-hour food records (24hFR) and 24-hour urine excretion (24UE) samples were collected twice in summer and twice in winter on nonconsecutive days with a 14-day interval, resulting in a total of four collections per participant, and food consumption frequencies (FFQs) were determined. RESULTS: The most commonly used salt type among the participants was iodized table salt (56.8%). The mean sodium intake estimated from the 24-hour food record was significantly higher in the winter (3142.2 +/- 905.7 mg/day) compared to the summer (2479.6 +/- 793.5 mg/day) (p < 0.05). The mean sodium and potassium intakes estimated by the 24-hour food record were similar to those determined by urinary sodium and potassium excretion at the group level in both seasons, although correlations at the individual level were weak. The difference between the measurement methods for sodium and potassium values ​​(FFQ, 24hFR, 24UE) in summer and winter was due to the frequency of food consumption. Protein intake estimated by the FFQ and food record methods was comparable; however, protein intake calculated from urinary excretion was higher than the estimated values. CONCLUSION: In conclusion, the 24-hour food record method, which is widely used in nutritional assessment, showed closer agreement with urinary sodium and potassium excretion at the group (mean) level rather than at the individual ranking level, but underestimated protein intake in this study. These findings highlight the need for complementary biochemical markers when assessing protein consumption in population-based dietary surveys. FAU - Kurtgil, Seren AU - Kurtgil S AUID- ORCID: 0000-0002-2289-2594 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, SANKO University, Incili Pinar, Gazi Muhtar Pasa Boulevard. No: 36, Sehitkamil/Gaziantep, 27090, Turkey. serenkurtgil@gmail.com. FAU - Erbagci, Mustafa Anil AU - Erbagci MA AUID- ORCID: 0000-0002-7842-5741 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Hasan Kalyoncu University, Airport Road 8th Km, 27000, Sahinbey/Gaziantep, Turkey. FAU - Pekcan, Ayla Gulden AU - Pekcan AG AUID- ORCID: 0000-0002-2037-3037 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Lokman Hekim University, Sogutozu Neighborhood 2185 Street No:20/J, Cankaya, Ankara, 06510, Turkey. LA - eng GR - 223S330/TUBITAK 1002-A Program/ PT - Comparative Study PT - Journal Article PT - Observational Study PT - Validation Study DEP - 20260225 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 RN - 0 (Biomarkers) RN - 0 (Dietary Proteins) RN - 0 (Potassium, Dietary) RN - 0 (Sodium, Dietary) RN - 9NEZ333N27 (Sodium) RN - RWP5GA015D (Potassium) SB - IM MH - Humans MH - Female MH - Biomarkers/urine MH - Adult MH - *Diet Records MH - *Dietary Proteins/administration & dosage/urine MH - *Potassium, Dietary/urine/administration & dosage MH - Young Adult MH - Cross-Sectional Studies MH - *Sodium, Dietary/urine/administration & dosage MH - Adolescent MH - Reproducibility of Results MH - Surveys and Questionnaires MH - Nutrition Assessment MH - Sodium/urine MH - Seasons MH - Potassium/urine PMC - PMC13040766 OTO - NOTNLM OT - 24-hour food record OT - 24-hour urine excretion OT - Potassium OT - Protein OT - Sodium OT - Urea COIS- Declarations. Ethics approval and consent to participate: Ethics committee approval for the study was obtained from the SANKO University Clinical Research Ethics Committee (decision number 2023/07 - 01). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/26 15:23 MHDA- 2026/06/28 00:38 PMCR- 2026/02/25 CRDT- 2026/02/26 00:03 PHST- 2025/11/13 00:00 [received] PHST- 2026/02/22 00:00 [accepted] PHST- 2026/06/28 00:38 [medline] PHST- 2026/02/26 15:23 [pubmed] PHST- 2026/02/26 00:03 [entrez] PHST- 2026/02/25 00:00 [pmc-release] AID - 10.1186/s12937-026-01298-7 [pii] AID - 1298 [pii] AID - 10.1186/s12937-026-01298-7 [doi] PST - epublish SO - Nutr J. 2026 Feb 25;25(1):32. doi: 10.1186/s12937-026-01298-7. PMID- 41741364 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260826 IS - 1475-2662 (Electronic) IS - 0007-1145 (Print) IS - 0007-1145 (Linking) VI - 135 IP - 12 DP - 2026 Jun 28 TI - Anxiety-metabolism networks in human anorexia nervosa: Responses to caloric and non-caloric meals in the Networks Integrating Anxiety and Metabolism in Anorexia Nervosa (NAMA) randomized trial. PG - 1373-1383 LID - 10.1017/S0007114526106448 [doi] AB - Anorexia nervosa (AN) is an eating disorder that is mediated by psychological and metabolic factors, yet it is unclear how these factors interact. The NAMA trial objective is to clarify the metabo-psychiatric interaction and identify how it affects AN patients' behaviour. This randomised trial will recruit thirty-six treatment-naive female AN patients, 13-18 years of age, and thirty-six matched healthy controls. Participants will undergo psychiatric assessments followed by 12-h overnight fasting. The next morning, baseline assessments of outcomes will be performed. Patients will be randomly allocated 1:1 to receive a mixture with calories or receive a mixture without calories. Healthy controls will also be allocated to receive mixtures with/without calories. Mixtures will be standardised for taste and appearance, and allocation will be masked. The primary outcome measure is resting-state functional MRI 60 min post-consumption of the mixture. Secondary outcomes include (1) blood samples to study markers reflecting metabolic states, hunger/satiety and stress responses, (2) psychometric evaluations of subjective experiences and (3) assessment, in a second meal 3 h later, of the effects of previous calorie intake on subsequent food consumption. This article describes the study protocol, including the analysis plan, for a randomised controlled trial to comprehensively evaluate the effects of calorie intake in AN. The trial will distinguish psychological and metabolic neuronal networks associated with food intake and uncover how their integration affects food intake and other hallmark symptoms in AN. The aim is to accelerate treatment development by identifying brain mechanisms that drive AN. FAU - Ekback, Erik AU - Ekback E AUID- ORCID: 0000-0003-0496-7158 AD - Department of Clinical Sciences, Umea University, Umea, Sweden. ROR: https://ror.org/05kb8h459 AD - Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden. AD - Wallenberg Centre for Molecular Medicine, Umea University, Umea, Sweden. ROR: https://ror.org/05kb8h459 FAU - Yalcin, Lal AU - Yalcin L AD - Department of Psychiatry, Ege University, Izmir, Turkey. FAU - Ozalay, Ozgun AU - Ozalay O AD - Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, USA. FAU - Granasen, Gabriel AU - Granasen G AD - Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden. FAU - Ozbaran, Burcu AU - Ozbaran B AD - Department of Child and Adolescent Psychiatry, Ege University, Izmir, Turkey. FAU - Gonul, Ali Saffet AU - Gonul AS AD - Department of Psychiatry, Ege University, Izmir, Turkey. FAU - Lagerlof, Olof AU - Lagerlof O AD - Department of Clinical Sciences, Umea University, Umea, Sweden. ROR: https://ror.org/05kb8h459 AD - Wallenberg Centre for Molecular Medicine, Umea University, Umea, Sweden. ROR: https://ror.org/05kb8h459 AD - Department of Medical Translational Biology, Umea University, Umea, Sweden. ROR: https://ror.org/05kb8h459 LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260226 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM MH - Humans MH - *Anorexia Nervosa/psychology/metabolism MH - Female MH - Adolescent MH - *Energy Intake MH - *Anxiety/metabolism/psychology MH - Meals MH - Magnetic Resonance Imaging MH - Hunger PMC - PMC13423519 OTO - NOTNLM OT - Anorexia nervosa OT - Food intake OT - MRI OT - Randomised controlled trial OT - Study protocol EDAT- 2026/02/26 15:23 MHDA- 2026/07/29 18:38 PMCR- 2026/07/30 CRDT- 2026/02/25 22:42 PHST- 2026/07/29 18:38 [medline] PHST- 2026/02/26 15:23 [pubmed] PHST- 2026/02/25 22:42 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - S0007114526106448 [pii] AID - 10.1017/S0007114526106448 [doi] PST - ppublish SO - Br J Nutr. 2026 Jun 28;135(12):1373-1383. doi: 10.1017/S0007114526106448. Epub 2026 Feb 26. PMID- 41741096 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260912 IS - 1878-1888 (Electronic) IS - 0005-7894 (Print) IS - 0005-7894 (Linking) VI - 57 IP - 2 DP - 2026 Mar TI - Low-Burden Detection of Clinical Worsening in Body Dysmorphic Disorder Using Smartphone Sensor and Demographic Data. PG - 220-233 LID - S0005-7894(25)00092-9 [pii] LID - 10.1016/j.beth.2025.09.001 [doi] AB - Body dysmorphic disorder (BDD) is characterized by distressing preoccupations with perceived appearance flaws, leading to functional impairment and suicidal ideation (SI). Traditional approaches for monitoring clinical deterioration in BDD include self-reports and clinician assessments, which can miss acute changes in risk due to infrequent administration and recall biases. Alternatively, real-time monitoring via smartphones and wearable devices can enable low-burden early detection of deterioration, identifying intervention opportunities before someone's condition critically worsens. This study tests the feasibility of using smartphone sensor and demographic data to predict daily clinical acuity. Eighty-two participants with BDD completed ecological momentary assessments (EMA) over 28 days, reporting levels of SI, BDD-related avoidance, and time spent on BDD-related concerns. Smartphone sensor data were collected for 3 months that overlapped with EMA. Machine learning models were trained to predict same-day levels of SI, avoidance, and time spent on BDD using the Global Positioning System (GPS), accelerometer, and demographic data. We evaluated model performance using mean absolute error, Pearson and Spearman correlations, and permutation tests. Random forest (RF) models using time and random split validation outperformed dummy regressor models across outcomes (maximum SI, mean SI, maximum avoidance, mean avoidance, time spent on BDD-related behaviors). Pearson correlations for RF models showed strong predictive performance for BDD-related time (r = .74-.75) and mean and max SI (r = .70-.73). Mean and max avoidance was moderately well predicted (r = .56-.62). Step count and demographic factors (e.g., education, living situation) were the most consistent and important features. This study provides initial evidence that smartphone sensor and demographic data can be used to monitor real-time clinical worsening in BDD, without burdening the patient. This work has potential for building just-in-time interventions that are delivered as deterioration onsets, to prevent its escalation. Future research should test these models in real-world datasets collected over longer periods and subsequently explore integration into interventions and clinical decision making. Trial Registration: ClinicalTrials.gov Identifier: NCT04254575. CI - Copyright (c) 2025 Association for Behavioral and Cognitive Therapies. Published by Elsevier Ltd. All rights reserved. FAU - Weingarden, Hilary AU - Weingarden H AD - Massachusetts General Hospital and Harvard Medical School. Electronic address: hilaryweingarden@gmail.com. FAU - Holstein, Vincent AU - Holstein V AD - Massachusetts General Hospital and Harvard Medical School. FAU - Jonathan, Geneva K AU - Jonathan GK AD - Massachusetts General Hospital and Harvard Medical School. FAU - Armey, Michael AU - Armey M AD - Butler Hospital and Alpert Medical School of Brown University. FAU - Onnela, Jukka-Pekka AU - Onnela JP AD - Harvard T. H. Chan School of Public Health. FAU - Wilhelm, Sabine AU - Wilhelm S AD - Massachusetts General Hospital and Harvard Medical School. LA - eng SI - ClinicalTrials.gov/NCT04254575 GR - K23 MH119372/MH/NIMH NIH HHS/United States PT - Journal Article PT - Observational Study DEP - 20250911 PL - England TA - Behav Ther JT - Behavior therapy JID - 1251640 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - *Body Dysmorphic Disorders/diagnosis/psychology MH - Ecological Momentary Assessment MH - Machine Learning MH - *Smartphone MH - Suicidal Ideation PMC - PMC12946665 MID - NIHMS2110672 OTO - NOTNLM OT - body dysmorphic disorder OT - clinical deterioration OT - digital phenotyping OT - ecological momentary assessment OT - suicidal ideation COIS- Hilary Weingarden received research support from the National Institute of Mental Health (NIMH; K23MH119372) to conduct this project. Dr. Weingarden receives salary from HabitAware, Inc., has current or prior paid consulting or scientific advisory agreements with Hello Therapeutics, Inc. Augmend Health, and APA Labs, and has received research support from Koa Health, Inc. Dr. Wilhelm is a presenter for the Massachusetts General Hospital Psychiatry Academy in educational programs supported through independent medical education grants from pharmaceutical companies; she has received royalties from Elsevier Publications, Guilford Publications, New Harbinger Publications, Springer, and Oxford University Press. She has received speaking honoraria from various academic institutions and foundations, including the International Obsessive Compulsive Disorder Foundation, the Tourette Association of America and the Centers for Disease Control and Prevention. In addition, she received payment from the Association for Behavioral and Cognitive Therapies for her role as Associate Editor for the Behavior Therapy journal, as well as from John Wiley & Sons, Inc. for her role as Associate Editor on the journal Depression & Anxiety. Dr. Wilhelm has also received honoraria from One-Mind for her role in PsyberGuide Scientific Advisory Board. Dr. Wilhelm is also on the Scientific Advisory Board for Koa Health, Inc. Jimini Health and for Noom, Inc. Dr. Wilhelm has received research and salary support from Koa Health, Inc. Michael Armey is a compensated member of Ilumivu's scientific advisory board and could potentially benefit from the results of this research. Drs. Holstein, Onnela, and Jonathan: None declared. EDAT- 2026/02/26 15:23 MHDA- 2026/03/06 09:08 PMCR- 2026/09/11 CRDT- 2026/02/25 20:56 PHST- 2025/05/12 00:00 [received] PHST- 2025/07/22 00:00 [revised] PHST- 2025/09/08 00:00 [accepted] PHST- 2026/03/06 09:08 [medline] PHST- 2026/02/26 15:23 [pubmed] PHST- 2026/02/25 20:56 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - S0005-7894(25)00092-9 [pii] AID - 10.1016/j.beth.2025.09.001 [doi] PST - ppublish SO - Behav Ther. 2026 Mar;57(2):220-233. doi: 10.1016/j.beth.2025.09.001. Epub 2025 Sep 11. PMID- 41739288 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20261009 IS - 1534-3170 (Electronic) IS - 1523-3782 (Linking) VI - 28 IP - 1 DP - 2026 Feb 25 TI - Improving National Fitness: An Updated Review on Cardiovascular Disease Risk Screening and Exercise Training in School-Aged Children in the U.S. LID - 28 [pii] LID - 10.1007/s11886-026-02348-6 [doi] AB - PURPOSE OF REVIEW: To synthesize contemporary evidence on school-feasible cardiovascular disease (CVD) risk screening and exercise training (ET) for U.S. children (ages 6-17) and to outline a pragmatic national framework that prioritizes fitness over size-based metrics. RECENT FINDINGS: Anthropometric indicators such as body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) remain practical, low-cost tools for identifying obesity-related cardiometabolic risk in schools. When complemented by blood pressure (BP) measurement, they provide a more complete profile. However, all anthropometric and hemodynamic measures are inferior to cardiorespiratory fitness (CRF), which more strongly predicts future CVD risk and all-cause mortality. Both aerobic ET (aET) and resistance ET (rET) independently enhance CRF and muscular strength (MusS), yielding additive cardiometabolic benefits independent of weight loss. Implementation remains limited by reduced physical education (PE) time (PET), fragmented data systems, and insufficient teacher training. A unified national framework emphasizing CRF as a clinical vital sign, standardized screening, and structured ET in schools offers a low-cost, high-impact strategy to curb pediatric CVD risk. Policy efforts should promote validated field tests, teacher training, and integration with pediatric care networks. Shifting the focus from weight reduction to fitness optimization after establishing proper technique reduces stigma, boosts participation, and fosters lifelong physical literacy. Embedding evidence-based screening and ET into educational infrastructure could redefine preventive cardiology, positioning schools as a foundation of cardiovascular health promotion. FAU - Mendoza, Michael F AU - Mendoza MF AD - Ochsner Cancer Institute, The Gayle and Tom Benson Cancer Center, New Orleans, LA, 70121, USA. michael.mendoza@ochsner.org. AD - Faculty of Medicine and Surgery, University of Santo Tomas, Metro Manila, Philippines. michael.mendoza@ochsner.org. AD - Department of Cardiovascular Diseases, Ochsner Clinical School, John Ochsner Heart and Vascular Institute, The University of Queensland School of Medicine, New Orleans, LA, USA. michael.mendoza@ochsner.org. FAU - Anzelmo, Michael A AU - Anzelmo MA AD - Department of Internal Medicine, Ochsner Clinic Foundation, New Orleans, LA, USA. FAU - Suan, Nina M AU - Suan NM AD - Faculty of Medicine and Surgery, University of Santo Tomas, Metro Manila, Philippines. FAU - Fourchy, Marie-Claire AU - Fourchy MC AD - Independent Researcher, New Orleans, LA, USA. FAU - Lavie, Carl J AU - Lavie CJ AD - Department of Cardiovascular Diseases, Ochsner Clinical School, John Ochsner Heart and Vascular Institute, The University of Queensland School of Medicine, New Orleans, LA, USA. LA - eng PT - Journal Article PT - Review DEP - 20260225 PL - United States TA - Curr Cardiol Rep JT - Current cardiology reports JID - 100888969 SB - IM MH - Humans MH - Child MH - *Cardiovascular Diseases/prevention & control MH - United States/epidemiology MH - *Cardiorespiratory Fitness MH - *Mass Screening/methods MH - *Physical Fitness MH - *Exercise MH - Heart Disease Risk Factors MH - Adolescent MH - *Physical Education and Training MH - Risk Assessment MH - Body Mass Index MH - School Health Services MH - Health Promotion MH - Risk Factors OTO - NOTNLM OT - Cardiorespiratory fitness OT - Cardiovascular disease OT - Exercise training OT - Obesity OT - School OT - Screening COIS- Declarations. Human and Animal Rights and Informed Consent: No studies involving human participants or animals were conducted by the authors for this review article. All data discussed are derived from previously published studies that complied with recognized ethical standards. Competing Interests: Dr. Lavie reports being on a data and safety monitoring board for Novo Nordisk for their REDEFINE 3 Trial with CagriSema (but in adults). The other authors declare that they have no conflicts of interest to disclose. EDAT- 2026/02/25 13:37 MHDA- 2026/06/28 13:04 CRDT- 2026/02/25 11:21 PHST- 2026/01/13 00:00 [received] PHST- 2026/02/12 00:00 [accepted] PHST- 2026/06/28 13:04 [medline] PHST- 2026/02/25 13:37 [pubmed] PHST- 2026/02/25 11:21 [entrez] AID - 10.1007/s11886-026-02348-6 [pii] AID - 10.1007/s11886-026-02348-6 [doi] PST - epublish SO - Curr Cardiol Rep. 2026 Feb 25;28(1):28. doi: 10.1007/s11886-026-02348-6. PMID- 41738735 OWN - NLM STAT- MEDLINE DCOM- 20260616 LR - 20260616 IS - 1699-5198 (Electronic) IS - 0212-1611 (Linking) VI - 43 IP - 3 DP - 2026 Jun 16 TI - Psychometric properties of the Feeding Practices and Structure Questionnaire for Infants under 6 months of age in Mexican mothers. PG - 520-529 LID - 10.20960/nh.06128 [doi] AB - Introduction: early infant feeding practices play a crucial role in shaping long-term dietary behaviors and health outcomes. However, validated instruments to assess these practices in infants under six months are scarce, particularly in low -and middle- income countries. The Feeding Practices and Structure Questionnaire for Infants - Milk Feeding version (FPSQ-M) was originally developed in Australia, but its applicability in diverse cultural contexts requires validation. Objective: to translate, culturally adapt, and validate the FPSQ-M for use among Mexican mothers with infants under six months of age. Methods: this cross-sectional study involved 197 Mexican mothers. The FPSQ-M underwent translation, cultural adaptation, and psychometric validation. Construct validity was evaluated through Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA). Internal consistency was assessed using Cronbach's alpha, and measurement invariance by maternal education level was tested using multigroup analysis. Results: the EFA identified a four-factor structure, explaining 56.49 % of the variance, aligning with the original FPSQ-M. CFA, after removing two low-loading items, showed improved model fit (GFI = 0.901, CFI = 0.916, RMSEA = 0.063). Measurement invariance confirmed that the FPSQ-M is equivalent across maternal educational groups. Internal consistency was acceptable across all dimensions. Conclusions: the FPSQ-M demonstrated strong psychometric properties in this Mexican sample, making it a reliable tool for assessing feeding practices. Its use is recommended in future research and public health interventions aimed at promoting responsive feeding and preventing early childhood obesity. FAU - Cardenas Villarreal, Velia Margarita AU - Cardenas Villarreal VM AD - School of Nursing. Universidad Autonoma de Nuevo Leon. FAU - Mayo Abarca, Jorge Alberto AU - Mayo Abarca JA AD - School of Nursing and Obstetrics. Universidad de la Salud del Estado de Puebla. FAU - Ortiz Rodriguez, Jeyle AU - Ortiz Rodriguez J AD - School of Public Accounting and Administration. Universidad Autonoma de Nuevo Leon. FAU - Martinez Figueroa, Gabriela Iveth AU - Martinez Figueroa GI AD - School of Public Accounting and Administration. Universidad Autonoma de Nuevo Leon. FAU - Camarillo Cardenas, Karen Paola AU - Camarillo Cardenas KP AD - Independent Researcher. FAU - Hernandez Martinez, Nora AU - Hernandez Martinez N AD - School of Nursing. Universidad Autonoma de Nuevo Leon. LA - eng PT - Journal Article TT - Propiedades psicometricas del Cuestionario de Practicas y Estructura de Alimentacion de Lactantes menores de 6 meses en madres mexicanas. PL - Spain TA - Nutr Hosp JT - Nutricion hospitalaria JID - 9100365 SB - IM MH - Humans MH - Female MH - Mexico MH - Infant MH - Psychometrics MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - *Feeding Behavior MH - *Mothers/psychology MH - Adult MH - Reproducibility of Results MH - Factor Analysis, Statistical MH - Young Adult OTO - NOTNLM OT - Practicas de alimentacion. Validacion psicometrica. Comportamiento alimentario de los padres. Cuestionarios y encuestas. Obesidad infantil. Lactantes. EDAT- 2026/02/25 13:35 MHDA- 2026/06/16 13:32 CRDT- 2026/02/25 08:53 PHST- 2026/06/16 13:32 [medline] PHST- 2026/02/25 13:35 [pubmed] PHST- 2026/02/25 08:53 [entrez] AID - 10.20960/nh.06128 [doi] PST - ppublish SO - Nutr Hosp. 2026 Jun 16;43(3):520-529. doi: 10.20960/nh.06128. PMID- 41737649 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260225 LR - 20260813 IS - 1178-7007 (Print) IS - 1178-7007 (Electronic) IS - 1178-7007 (Linking) VI - 19 DP - 2026 TI - Causal Risk Factors for Type 1 Diabetes in Mendelian Randomization Studies: A Systematic Review and Meta-Analysis. PG - 568784 LID - 10.2147/DMSO.S568784 [doi] LID - 568784 AB - BACKGROUND: Type 1 diabetes mellitus (T1DM) is a chronic disease mediated by autoimmunity, with complex and not fully elucidated pathogenesis. Mendelian randomization (MR) utilizes genetic instrumental variables to minimize confounding and reverse causation; however, individual MR studies are often limited by sample size and result heterogeneity. METHODS: Following PRISMA 2020 guidelines, we systematically searched PubMed, Web of Science, and other databases from 2014 to 2025, ultimately including 53 MR studies (covering 243 exposures). Random-effects models were used to pool effect sizes. Heterogeneity was quantified by Cochran's Q test and I(2) statistic. Bias was further controlled using Egger's regression and leave-one-out sensitivity analysis. RESULTS: This study integrated 53 MR studies (243 exposures) and identified key causal factors for T1DM.IL2RA (OR = 0.22, 95% CI: 0.17-0.27) and TYK2 (OR = 0.61, 95% CI: 0.54-0.69) showed significant protective effects, while IL6R (OR = 1.98, 95% CI: 1.48-2.65) was associated with increased risk. For metabolites, 3-phenylpropionic acid (OR = 0.90, 95% CI: 0.85-0.96) and cinnamoylglycine (OR = 0.89, 95% CI: 0.84-0.96) were protective, while trimethylamine N-oxide (TMAO; OR = 1.11, 95% CI: 1.02-1.20) increased risk. Among gut microbiota, Prevotella 9 (OR = 1.18, 95% CI: 1.08-1.30) was positively associated with risk, whereas Bifidobacterium (OR = 0.82, 95% CI: 0.71-0.95) showed a protective effect. Childhood obesity (OR = 1.32, 95% CI: 1.06-1.64) was also associated with increased T1DM risk. Overall heterogeneity was high (I(2) = 78.3%). CONCLUSION: This study systematically mapped the multi-omics causal risk landscape of T1DM, providing important evidence for precision prevention and targeted intervention. These findings suggest that targeting immune pathways (particularly IL2RA and TYK2) and modulating gut microbiota composition may represent promising strategies for T1DM prevention. Future research should emphasize cross-ethnic validation and life-stage-specific intervention strategies. CI - (c) 2026 Li et al. FAU - Li, Mali AU - Li M AD - Department of Endocrinology, Genetics and Metabolism, Xi'an Children's Hospital, Xi'an, Shaanxi Province, 710003, People's Republic of China. AD - Department of Endocrinology, Genetics and Metabolism, Children's Hospital Affiliated to Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710003, People's Republic of China. FAU - Shen, Panting AU - Shen P AD - Department of Endocrinology, Genetics and Metabolism, Xi'an Children's Hospital, Xi'an, Shaanxi Province, 710003, People's Republic of China. AD - Department of Endocrinology, Genetics and Metabolism, Children's Hospital Affiliated to Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710003, People's Republic of China. FAU - Liu, Chao AU - Liu C AD - Department of Endocrinology, Genetics and Metabolism, Xi'an Children's Hospital, Xi'an, Shaanxi Province, 710003, People's Republic of China. AD - Department of Endocrinology, Genetics and Metabolism, Children's Hospital Affiliated to Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710003, People's Republic of China. FAU - Li, Jia AU - Li J AD - Department of Endocrinology, Genetics and Metabolism, Xi'an Children's Hospital, Xi'an, Shaanxi Province, 710003, People's Republic of China. AD - Department of Endocrinology, Genetics and Metabolism, Children's Hospital Affiliated to Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710003, People's Republic of China. FAU - Qiu, Shichao AU - Qiu S AD - Department of Endocrinology, Genetics and Metabolism, Xi'an Children's Hospital, Xi'an, Shaanxi Province, 710003, People's Republic of China. AD - Department of Endocrinology, Genetics and Metabolism, Children's Hospital Affiliated to Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710003, People's Republic of China. FAU - Wang, Zhihua AU - Wang Z AUID- ORCID: 0009-0004-6655-6607 AD - Department of Endocrinology, Genetics and Metabolism, Xi'an Children's Hospital, Xi'an, Shaanxi Province, 710003, People's Republic of China. AD - Department of Endocrinology, Genetics and Metabolism, Children's Hospital Affiliated to Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710003, People's Republic of China. LA - eng PT - Journal Article PT - Review DEP - 20260219 PL - New Zealand TA - Diabetes Metab Syndr Obes JT - Diabetes, metabolic syndrome and obesity : targets and therapy JID - 101515585 PMC - PMC12927793 OTO - NOTNLM OT - Mendelian randomization OT - causal risk factors OT - meta-analysis OT - multi-omics OT - type 1 diabetes mellitus COIS- The authors declare no conflicts of interest. EDAT- 2026/02/25 10:20 MHDA- 2026/02/25 10:21 PMCR- 2026/02/19 CRDT- 2026/02/25 04:52 PHST- 2025/09/25 00:00 [received] PHST- 2026/01/19 00:00 [accepted] PHST- 2026/02/25 10:21 [medline] PHST- 2026/02/25 10:20 [pubmed] PHST- 2026/02/25 04:52 [entrez] PHST- 2026/02/19 00:00 [pmc-release] AID - 568784 [pii] AID - 10.2147/DMSO.S568784 [doi] PST - epublish SO - Diabetes Metab Syndr Obes. 2026 Feb 19;19:568784. doi: 10.2147/DMSO.S568784. eCollection 2026. PMID- 41737351 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 15 DP - 2026 TI - Development and validation of an educational comic book on healthy eating in early childhood. PG - e14 LID - 10.1017/jns.2025.10072 [doi] LID - e14 AB - The objective of this study was to develop and validate an educational comic book designed to promote healthy eating among caregivers of young children. The study was conducted in four phases: (1) literature review and script development; (2) creation of the initial version of the comic book, including illustrations, layout and design, and calculation of the Flesch Readability Index (FI); (3) expert validation of the initial version and calculation of the Content Validity Index (CVI); and (4) adaptation of the comic book based on expert suggestions, recalculation of the FI, and pilot testing (CVI) with a lay population. A total of 64 volunteers participated in the validation process, including 14 expert judges and 50 caregivers responsible for feeding children aged 0 to 5 years. Statistical analysis included descriptive measures and inferential testing using the Wilcoxon signed-rank test. The FI score for the initial version was 85.0%, indicating a reading level classified as "easy to understand." After expert evaluation, the CVI reached 94%, reflecting high agreement among participants. In the revised version, the FI remained high at 84.7%, reinforcing the "easy to understand" reading level, while the CVI increased to 98% following the pilot test, demonstrating strong consensus among participants. A significant improvement in knowledge regarding healthy eating was observed after reading the comic book (p < 0.05). The comic book was validated for appearance, content and readability, showing a positive impact on caregivers' knowledge about healthy eating practices. It represents an accessible and effective resource that can be integrated into community-based nutrition education programmes. CI - (c) The Author(s) 2026. FAU - Soares, Cristiano Carvalho AU - Soares CC AD - Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. ROR: https://ror.org/03m1j9m44 AD - Universidade Federal de Lavras (UFLA), Lavras, MG, Brazil. FAU - Zanin, Luciane AU - Zanin L AD - Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. ROR: https://ror.org/03m1j9m44 FAU - Sperandio, Marcelo AU - Sperandio M AD - Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. ROR: https://ror.org/03m1j9m44 FAU - Florio, Flavia Martao AU - Florio FM AUID- ORCID: 0000-0001-7742-0255 AD - Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. ROR: https://ror.org/03m1j9m44 LA - eng PT - Journal Article PT - Validation Study DEP - 20260205 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 SB - IM MH - Humans MH - Child, Preschool MH - Infant MH - *Diet, Healthy MH - *Comic Books as Topic MH - Female MH - *Health Promotion/methods MH - Comprehension MH - Male MH - *Health Education/methods MH - Caregivers/education MH - Health Knowledge, Attitudes, Practice MH - Reproducibility of Results MH - Pilot Projects PMC - PMC12926666 OTO - NOTNLM OT - Child OT - Comic book OT - Food and nutrition education OT - Food and nutritional health promotion OT - Health education OT - Preschool OT - Validation study COIS- The authors declare that they have no conflicts of interest. EDAT- 2026/02/25 10:21 MHDA- 2026/02/25 10:22 PMCR- 2026/02/05 CRDT- 2026/02/25 04:49 PHST- 2025/04/25 00:00 [received] PHST- 2025/11/13 00:00 [revised] PHST- 2025/12/18 00:00 [accepted] PHST- 2026/02/25 10:22 [medline] PHST- 2026/02/25 10:21 [pubmed] PHST- 2026/02/25 04:49 [entrez] PHST- 2026/02/05 00:00 [pmc-release] AID - S2048679025100724 [pii] AID - 10.1017/jns.2025.10072 [doi] PST - epublish SO - J Nutr Sci. 2026 Feb 5;15:e14. doi: 10.1017/jns.2025.10072. eCollection 2026. PMID- 41736948 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260225 LR - 20260813 IS - 1664-042X (Print) IS - 1664-042X (Electronic) IS - 1664-042X (Linking) VI - 17 DP - 2026 TI - Effects of the modified field test on exercise-induced peripheral fatigue in non-elite badminton players. PG - 1734224 LID - 10.3389/fphys.2026.1734224 [doi] LID - 1734224 AB - OBJECTIVES: This study aimed to examine the effects of a modified badminton field test (FT) on exercise-induced peripheral fatigue and its underlying responses in non-elite male college badminton players. We hypothesized that the repeated high-intensity intermittent efforts during the modified FT would lead to significant reductions in lower-limb muscle performance and elevate markers of peripheral fatigue, including blood lactate accumulation, perceived exertion, and heart rate elevation. METHODS: In a single-arm repeated-measures design, 15 healthy male collegiate badminton players (age: 20.2 +/- 0.9 years; BMI: 20.9 +/- 1.5 kg/m(2); playing experience: 1.3 +/- 0.4 years) performed five consecutive sets of the field test interspersed with 60 s of passive recovery. Each set involved on-court shuttle runs to eight LED targets and was terminated upon volitional exhaustion, achievement of heart rate >/=92% HRmax, or an RPE >/=18 (Borg 6-20 scale). Markers of peripheral fatigue-vertical jump height (VJ), heart rate (HR), rating of perceived exertion (RPE), and fingertip blood lactate (BL)-were assessed before the test and after each set. Data were analyzed using one-way repeated-measures ANOVA (for VJ, HR, RPE) and paired t-tests (for BL). RESULTS: VJ height progressively decreased from 41.8 +/- 4.7 cm at baseline to 25.5 +/- 4.5 cm after set 5 (Delta = 39.9%, eta(2)p = 0.60, large effect size; p < 0.001). Concurrent increases were observed in HR (63.5 +/- 3.8 to 178.0 +/- 3.9 bpm; eta(2)p = 0.96, large effect size), RPE (6-18.7 +/- 0.9; eta(2)p = 0.95, large effect size), and BL (2.82 +/- 1.12 to 16.07 +/- 2.52 mmol L(-1); Cohen's d = 6.8, large effect size; all p < 0.001). These convergent metabolic, neuromuscular, and perceptual responses confirm the induction of pronounced peripheral fatigue. CONCLUSION: A single 15-min modified badminton FT reliably elicits marked peripheral fatigue in non-elite male players. The protocol provides coaches with an ecologically valid, low-cost and high-safety tool to monitor training load and mitigate fatigue-related injury risk. Future research should validate the FT in female and youth cohorts and explore longitudinal applications. CI - Copyright (c) 2026 Huang, Song, Huang, Zeng, Li and Liu. FAU - Huang, Heping AU - Huang H AD - Institute of Physical Education and Sports, Huzhou University, Huzhou, Zhejiang, China. FAU - Song, Jian AU - Song J AD - College of Physical Education and Health, China Pharmaceutical University, Nanjing, Jiangsu, China. FAU - Huang, Huiming AU - Huang H AD - College of Physical Education and Health, China Pharmaceutical University, Nanjing, Jiangsu, China. AD - Faculty of Sports Science, Ningbo University, Ningbo, Zhejiang, China. FAU - Zeng, Yufan AU - Zeng Y AD - Institute of Physical Education and Sports, Huzhou University, Huzhou, Zhejiang, China. FAU - Li, Xingchang AU - Li X AD - Institute of Physical Education, SuQian University, SuQian, Jiangsu, China. FAU - Liu, Su AU - Liu S AD - College of Physical Education and Health, China Pharmaceutical University, Nanjing, Jiangsu, China. LA - eng PT - Journal Article DEP - 20260209 PL - Switzerland TA - Front Physiol JT - Frontiers in physiology JID - 101549006 PMC - PMC12926157 OTO - NOTNLM OT - badminton OT - field test OT - peripheral fatigue OT - training load OT - vertical jump COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/25 10:23 MHDA- 2026/02/25 10:24 PMCR- 2026/02/09 CRDT- 2026/02/25 04:45 PHST- 2025/10/28 00:00 [received] PHST- 2025/12/30 00:00 [revised] PHST- 2026/01/19 00:00 [accepted] PHST- 2026/02/25 10:24 [medline] PHST- 2026/02/25 10:23 [pubmed] PHST- 2026/02/25 04:45 [entrez] PHST- 2026/02/09 00:00 [pmc-release] AID - 1734224 [pii] AID - 10.3389/fphys.2026.1734224 [doi] PST - epublish SO - Front Physiol. 2026 Feb 9;17:1734224. doi: 10.3389/fphys.2026.1734224. eCollection 2026. PMID- 41736762 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260225 LR - 20260813 IS - 1179-1411 (Print) IS - 1179-1411 (Electronic) IS - 1179-1411 (Linking) VI - 18 DP - 2026 TI - Basal Luteinizing Hormone Combined with Age and BMI as a Simplified Screening Model for Central Precocious Puberty in Girls. PG - 583959 LID - 10.2147/IJWH.S583959 [doi] LID - 583959 AB - PURPOSE: The gonadotropin-releasing hormone (GnRH) stimulation test is regarded as the diagnostic gold standard for central precocious puberty (CPP); however, its invasiveness and limited accessibility restrict its routine use in clinical practice. Moreover, reported cutoff values for basal luteinizing hormone (LH) vary across studies, and simple screening models applicable to everyday clinical settings remain limited. This study aimed to evaluate routinely available clinical, biochemical, and imaging indicators and to develop a simplified screening model for early differentiation of CPP from premature thelarche (PT) in girls. PATIENTS AND METHODS: This retrospective study included 429 girls aged 4-8 years presenting with early breast development between January 2019 and January 2023. Basal sex hormone levels, anthropometric parameters, bone age, and pelvic ultrasound findings were collected. Univariable analysis, multivariable logistic regression, and receiver operating characteristic (ROC) curve analysis were performed to assess the screening performance of individual indicators and a combined model. RESULTS: Girls with CPP exhibited significantly higher age, BMI, bone age advancement, basal LH levels, and ovarian volumes than those with PT did (all p<0.05). Multivariable analysis identified age, BMI, and basal LH concentration as independent factors associated with CPP. Among individual indicators, basal LH concentration showed the strongest discriminatory ability (AUC=0.842), with a cutoff value of 0.15 IU/L. A simplified combined model integrating basal LH concentration, age, and BMI further improved screening performance (AUC=0.880). Pelvic ultrasound parameters did not emerge as independent predictors in multivariable analyses. CONCLUSION: A simplified screening model incorporating basal LH concentration, age, and BMI may serve as a practical initial screening tool to identify girls at higher risk of CPP and to reduce unnecessary GnRH stimulation testing. Prospective multicenter studies are required to validate the generalizability of this approach before broader clinical implementation. CI - (c) 2026 Li et al. FAU - Li, Jiayu AU - Li J AD - Department of Child Healthcare, West China Second University Hospital, Sichuan University, Chengdu, People's Republic of China. AD - Department of Child Healthcare, Angel Women's and Children's Hospital, Chengdu, People's Republic of China. FAU - Cui, Yali AU - Cui Y AD - Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, People's Republic of China. AD - Department of Laboratory Medicine, Sichuan Provincial Children's Hospital (Sichuan Provincial Children's Medical Center), Meishan, People's Republic of China. AD - Department of Laboratory Medicine, Meishan Women and Children's Hospital, Meishan, People's Republic of China. FAU - Shuai, Jiaji AU - Shuai J AD - Department of Child Healthcare, Meishan Women and Children's Hospital, Meishan, People's Republic of China. FAU - Li, Wei AU - Li W AUID- ORCID: 0000-0003-4632-0248 AD - Department of Child Healthcare, West China Second University Hospital, Sichuan University, Chengdu, People's Republic of China. FAU - Li, Yingying AU - Li Y AD - Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, People's Republic of China. FAU - Yan, Ziyi AU - Yan Z AUID- ORCID: 0000-0003-3298-9311 AD - Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, People's Republic of China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, People's Republic of China. FAU - Yu, Tao AU - Yu T AD - Department of Child Healthcare, West China Second University Hospital, Sichuan University, Chengdu, People's Republic of China. AD - Department of Child Healthcare, Meishan Women and Children's Hospital, Meishan, People's Republic of China. LA - eng PT - Journal Article DEP - 20260216 PL - New Zealand TA - Int J Womens Health JT - International journal of women's health JID - 101531698 PMC - PMC12927745 OTO - NOTNLM OT - basal LH OT - body mass index OT - breast development OT - ovarian volume OT - precocious puberty COIS- The authors report no conflicts of interest in this work. EDAT- 2026/02/25 10:21 MHDA- 2026/02/25 10:22 PMCR- 2026/02/16 CRDT- 2026/02/25 04:43 PHST- 2025/11/24 00:00 [received] PHST- 2026/02/02 00:00 [accepted] PHST- 2026/02/25 10:22 [medline] PHST- 2026/02/25 10:21 [pubmed] PHST- 2026/02/25 04:43 [entrez] PHST- 2026/02/16 00:00 [pmc-release] AID - 583959 [pii] AID - 10.2147/IJWH.S583959 [doi] PST - epublish SO - Int J Womens Health. 2026 Feb 16;18:583959. doi: 10.2147/IJWH.S583959. eCollection 2026. PMID- 41735929 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Feb 24 TI - A detailed analysis of the effects of body parameters on motor function and fine motor skills measured at one-year intervals in patients with spinal muscular atrophy. LID - 10.1186/s12887-026-06583-2 [doi] LID - 245 AB - BACKGROUND: Spinal muscular atrophy mainly affects motor neurons in the spinal cord, leading to progressive muscular atrophy and weakness. This study aims to carefully analyse the effect of body parameters on motor function and fine motor skills, measured at one-year intervals, in patients with spinal muscular atrophy. METHODS: The study included 38 participants diagnosed with SMA. Patients were divided into three groups based on their level of motor function: non-sitters (n = 9), sitters (n = 23), and walkers (n = 6). Anthropometric measurements (weight, height/length) were taken in all participants, and BMI and BMI-z-score were calculated. The motor function was assessed using validated scales: CHOP-INTEND for the non-sitters group and HFMSE scale for the sitters and walkers group. The RULM scale assessed fine motor skills for the sitters and walkers group. RESULTS: At the 12-month follow-up, the CHOP-INTEND scale showed improvement in most non-sitter patients (6/9). The sitter's group was more heterogeneous on the HFMSE scale, with 10 out of 23 patients showing deterioration in function, 8 showing improvement, while the walker's group showed the least variability. In the non-sitters group, the dominant category of BMI z-score was underweight, while half of the sitters in the group were underweight, although there were just as many healthy weights. The strongest group, the walkers, was mostly healthy. We have observed a certain tendency that as BMI increases, motor function increases in all groups, while fine motor skill decreases in the most varied sitters group. CONCLUSIONS: As BMI increases in SMA patients, motor function improves. Fine motor skill deteriorates as BMI increases in the sitter's group. The assessment of individual components of motor function and fine motor skills reveals the actual changes that occur over time in patients with SMA. FAU - Gajewska, Ewa AU - Gajewska E AD - Chair and Clinic of the Developmental Neurology, Poznan University of Medical Sciences, Poznan, Poland. ewagajewska1011@gmail.com. FAU - Sobieska, Magdalena AU - Sobieska M AD - Department of Rehabilitation and Physiotherapy,, Poznan University of Medical Sciences, Poznan, Poland. FAU - Bieniaszewska, Aleksandra AU - Bieniaszewska A AD - Chair and Clinic of the Developmental Neurology, Poznan University of Medical Sciences, Poznan, Poland. FAU - Sowinska, Anna AU - Sowinska A AD - Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan, Poland. FAU - Michalska, Joanna AU - Michalska J AD - Chair and Clinic of the Developmental Neurology, Poznan University of Medical Sciences, Poznan, Poland. FAU - Steinborn, Barbara AU - Steinborn B AD - Chair and Clinic of the Developmental Neurology, Poznan University of Medical Sciences, Poznan, Poland. LA - eng PT - Journal Article DEP - 20260224 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Female MH - *Motor Skills/physiology MH - Male MH - Body Mass Index MH - Follow-Up Studies MH - Child, Preschool MH - *Spinal Muscular Atrophies of Childhood/physiopathology MH - Child MH - Infant MH - *Muscular Atrophy, Spinal/physiopathology PMC - PMC13037007 OTO - NOTNLM OT - BMI OT - BMI-z-score OT - Motor function OT - SMA OT - Upper limb COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Poznan University of Medical Sciences ethics committee nr 200/23. All parents signed informed consent before patient enrollment. Consent for publication: All authors consent to publication. Competing interests: The authors declare no competing interests. EDAT- 2026/02/25 00:29 MHDA- 2026/06/28 00:37 PMCR- 2026/02/24 CRDT- 2026/02/24 23:48 PHST- 2025/11/14 00:00 [received] PHST- 2026/01/27 00:00 [accepted] PHST- 2026/06/28 00:37 [medline] PHST- 2026/02/25 00:29 [pubmed] PHST- 2026/02/24 23:48 [entrez] PHST- 2026/02/24 00:00 [pmc-release] AID - 10.1186/s12887-026-06583-2 [pii] AID - 6583 [pii] AID - 10.1186/s12887-026-06583-2 [doi] PST - epublish SO - BMC Pediatr. 2026 Feb 24;26(1):245. doi: 10.1186/s12887-026-06583-2. PMID- 41735531 OWN - NLM STAT- In-Process LR - 20260831 IS - 1530-0447 (Electronic) IS - 0031-3998 (Print) IS - 0031-3998 (Linking) VI - 100 IP - 1 DP - 2026 Jul TI - Bridging the gap in paediatric MASLD screening: progress, pitfalls and the path ahead. PG - 40-42 LID - 10.1038/s41390-026-04763-5 [doi] AB - With a significant rise in the number of children with obesity worldwide, there has been a parallel increase in metabolic dysfunction-associated steatotic liver disease (MASLD), now the most common chronic liver disease in youth. MASLD remains substantially underdiagnosed, largely due to its asymptomatic early course, variability in guideline-recommended screening thresholds, and limited access to paediatric-specific diagnostic tools. In a large real-world cohort of 908 overweight and obese children, Lehtinen et al. provide one of the most comprehensive evaluations of MASLD screening implementation in routine care. Whilst screening uptake for ALT and metabolic comorbidities was high and broadly in line with international guidelines, under-recognition persisted, with retrospective MASLD prevalence nearly double clinician-documented rates. The study highlights limitations of ALT-based screening and inconsistent diagnostic criteria. It also reinforces the importance of structured exclusion testing to avoid misclassification of inherited or treatable liver diseases as MASLD. Current non-invasive tools for steatosis and fibrosis remain inadequately validated in children, underscoring an urgent unmet need in paediatric hepatology. Together, these findings emphasise the necessity for harmonised screening pathways, improved diagnostic algorithms, and broader access to practical non-invasive tools to enable earlier MASLD detection and intervention. FAU - Vimalesvaran, Sunitha AU - Vimalesvaran S AD - Department of Paediatric Gastroenterology, Hepatology and Nutrition, National University Hospital, Singapore, Singapore. FAU - Dhawan, Anil AU - Dhawan A AD - Paediatric Liver, GI and Nutrition Center and Mowat Labs, King's College Hospital, London, UK. anil.dhawan@kcl.ac.uk. LA - eng PT - Journal Article DEP - 20260224 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM PMC - PMC13524827 COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/02/25 00:29 MHDA- 2026/02/25 00:29 PMCR- 2026/02/24 CRDT- 2026/02/24 23:26 PHST- 2025/11/30 00:00 [received] PHST- 2025/12/22 00:00 [accepted] PHST- 2026/02/25 00:29 [pubmed] PHST- 2026/02/25 00:29 [medline] PHST- 2026/02/24 23:26 [entrez] PHST- 2026/02/24 00:00 [pmc-release] AID - 10.1038/s41390-026-04763-5 [pii] AID - 4763 [pii] AID - 10.1038/s41390-026-04763-5 [doi] PST - ppublish SO - Pediatr Res. 2026 Jul;100(1):40-42. doi: 10.1038/s41390-026-04763-5. Epub 2026 Feb 24. PMID- 41735242 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260921 IS - 1365-2982 (Electronic) IS - 1350-1925 (Print) IS - 1350-1925 (Linking) VI - 38 IP - 2 DP - 2026 Feb TI - Percutaneous Electrical Nerve Field Stimulation Improves Weight and Other Anthropometric Outcomes in Children and Adolescents With Functional Dyspepsia Who Restrict Their Oral Intake. PG - e70273 LID - 10.1111/nmo.70273 [doi] AB - BACKGROUND: Functional dyspepsia (FD), a disorder of the gut-brain interaction (DGBI), can result in restricted eating habits with associated weight loss. Percutaneous Electrical Nerve Field Stimulation (PENFS), a minimally invasive non-pharmacologic approach, can improve abdominal pain and psychological functioning in children with DGBI. We aimed to analyze changes in anthropometric measures, nutritional intake, and clinical outcomes with PENFS. METHODS: We retrospectively reviewed charts of patients with FD (9-28 years) who restricted oral intake and underwent PENFS. We analyzed validated questionnaires used during treatment. Anthropometric data were also assessed during and after 3 months of treatment. Results were analyzed through linear mixed modeling as least square means. KEY RESULTS: Ninety patients reported restricted oral intake, 42% had baseline weight loss and 13% requiring enteral support. Oral intake (p = 0.001), weight (p = 0.02) and BMI (p = 0.002) significantly increased after PENFS. Abdominal pain, nausea, functional disability, depression, and somatization also improved after PENFS. Increased weight Z scores were associated with lower nausea, pain catastrophizing, and depression. CONCLUSIONS AND INFERENCES: PENFS improved oral intake, weight, and other anthropometric measures in addition to GI and psychological measures in patients with FD. Changes in anthropometrics were sustained at 3-month follow up. PENFS may be an effective treatment for patients with FD, including children, and restrictive eating to optimize nutritional outcomes. Future studies should include prospective clinical trials and investigate the mechanism of action of PENFS on eating habits. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Waheed, Umber AU - Waheed U AD - Pediatrics, University of Cincinnati College of Medicine (UCCOM), Cincinnati, Ohio, USA. AD - Gastroenterology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, Ohio, USA. FAU - VonAxelson, Austin AU - VonAxelson A AD - Pediatrics, University of Cincinnati College of Medicine (UCCOM), Cincinnati, Ohio, USA. FAU - El-Chammas, Khalil AU - El-Chammas K AD - Pediatrics, University of Cincinnati College of Medicine (UCCOM), Cincinnati, Ohio, USA. AD - Gastroenterology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, Ohio, USA. FAU - Graham, Kahleb AU - Graham K AD - Pediatrics, University of Cincinnati College of Medicine (UCCOM), Cincinnati, Ohio, USA. AD - Gastroenterology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, Ohio, USA. FAU - Mansi, Sherief AU - Mansi S AD - Pediatrics, University of Cincinnati College of Medicine (UCCOM), Cincinnati, Ohio, USA. AD - Gastroenterology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, Ohio, USA. FAU - Hardy, Jennifer AU - Hardy J AD - Gastroenterology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, Ohio, USA. FAU - Miller, Megan M AU - Miller MM AUID- ORCID: 0000-0002-6222-2659 AD - Behavioral Medicine and Clinical Psychology, CCHMC, Cincinnati, Ohio, USA. FAU - Sahay, Rashmi AU - Sahay R AD - Biostatistics, CCHMC, Cincinnati, Ohio, USA. FAU - Santucci, Neha R AU - Santucci NR AD - Gastroenterology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, Ohio, USA. LA - eng GR - K23 DK135797/DK/NIDDK NIH HHS/United States PT - Journal Article PL - England TA - Neurogastroenterol Motil JT - Neurogastroenterology and motility JID - 9432572 SB - IM MH - Humans MH - *Dyspepsia/therapy/physiopathology/psychology MH - Female MH - Child MH - Adolescent MH - Male MH - Retrospective Studies MH - *Transcutaneous Electric Nerve Stimulation/methods MH - Treatment Outcome MH - Adult MH - Young Adult MH - *Body Weight/physiology MH - Weight Loss MH - Anthropometry MH - Abdominal Pain PMC - PMC13086553 MID - NIHMS2157096 OTO - NOTNLM OT - abdominal pain OT - functional dyspepsia OT - restricted eating OT - vagal neuromodulation OT - weight loss COIS- Conflicts of Interest Dr. Santucci is a consultant for Ironwood and a key opinion leader for Kate Farms and GI Health Foundation. Dr. Khalil El-Chammas is a consultant for Neuraxis Inc. who is responsible for IB-Stim, PENFS technology. EDAT- 2026/02/25 00:29 MHDA- 2026/02/25 00:30 PMCR- 2026/04/17 CRDT- 2026/02/24 23:03 PHST- 2026/01/22 00:00 [revised] PHST- 2025/10/23 00:00 [received] PHST- 2026/02/15 00:00 [accepted] PHST- 2026/02/25 00:30 [medline] PHST- 2026/02/25 00:29 [pubmed] PHST- 2026/02/24 23:03 [entrez] PHST- 2026/04/17 00:00 [pmc-release] AID - 10.1111/nmo.70273 [doi] PST - ppublish SO - Neurogastroenterol Motil. 2026 Feb;38(2):e70273. doi: 10.1111/nmo.70273. PMID- 41735142 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260709 IS - 2341-2879 (Electronic) IS - 2341-2879 (Linking) VI - 104 IP - 3 DP - 2026 Mar TI - A scoping review of methods of measuring smartphone usage. PG - 504156 LID - S2341-2879(26)00055-4 [pii] LID - 10.1016/j.anpede.2026.504156 [doi] AB - INTRODUCTION: Screen usage patterns have shifted significantly in recent years, with a notable increase in the use of internet-enabled smartphones among children and adolescents. OBJECTIVE: The aim of this scoping review was to describe the measurement tools used to estimate smartphone screen time in individuals aged less than 18 years. METHODS: We conducted a systematic search in MEDLINE Complete (via PubMed) and ScienceDirect for studies published between May 2014 and May 2024. A total of 89 population-based surveillance studies were included for analysis. RESULTS: The most common assessment method was the use of non-validated self-report questionnaires completed by parents. Only seven studies used a validated instrument, and in six of these cases, the tool was not specifically designed to measure screen time. Only one study applied a validated scale developed expressly for this purpose: the Screen Time Questionnaire (STQ). CONCLUSION: The heterogeneity of current findings on smartphone usage time among minors is evident. There is a clear need for a standardized questionnaire to accurately measure this variable and to support the development of evidence-based guidelines and recommendations. CI - Copyright (c) 2026 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L.U. All rights reserved. FAU - Cendrero-Luengo, Carmen AU - Cendrero-Luengo C AD - Grupo de Evaluacion de Determinantes de la Salud y Politicas Sanitarias, Universidad de Extremadura, Merida, Badajoz, Spain; Centro de estudios del uso saludable de pantallas durante la infancia (Kenko Lab), Spain. FAU - de Paz-Cantos, Sonia AU - de Paz-Cantos S AD - Centro de estudios del uso saludable de pantallas durante la infancia (Kenko Lab), Spain; Grupo de Evaluacion de Determinantes de Salud y Politicas Sanitarias, Departamento de Medicina, Universitat Internacional de Catalunya, Sant Cugat del Valles, Barcelona, Spain. FAU - Gonzalez-Marron, Adrian AU - Gonzalez-Marron A AD - Centro de estudios del uso saludable de pantallas durante la infancia (Kenko Lab), Spain; Grupo de Evaluacion de Determinantes de Salud y Politicas Sanitarias, Departamento de Medicina, Universitat Internacional de Catalunya, Sant Cugat del Valles, Barcelona, Spain. FAU - Lidon-Moyano, Cristina AU - Lidon-Moyano C AD - Centro de estudios del uso saludable de pantallas durante la infancia (Kenko Lab), Spain; Grupo de Evaluacion de Determinantes de Salud y Politicas Sanitarias, Departamento de Medicina, Universitat Internacional de Catalunya, Sant Cugat del Valles, Barcelona, Spain. FAU - Diez-Izquierdo, Ana AU - Diez-Izquierdo A AD - Centro de estudios del uso saludable de pantallas durante la infancia (Kenko Lab), Spain; Seccion de Neumologia y Alergologia Pediatricas, Servicio de Pediatria, Hospital Universitari Vall d'Hebron, Barcelona, Spain. FAU - Martinez-Sanchez, Jose M AU - Martinez-Sanchez JM AD - Grupo de Evaluacion de Determinantes de la Salud y Politicas Sanitarias, Universidad de Extremadura, Merida, Badajoz, Spain; Grupo de Evaluacion de Determinantes de Salud y Politicas Sanitarias, Departamento de Medicina, Universitat Internacional de Catalunya, Sant Cugat del Valles, Barcelona, Spain. Electronic address: jmmartinezs@unex.es. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260223 PL - Spain TA - An Pediatr (Engl Ed) JT - Anales de pediatria JID - 101765626 SB - IM MH - Humans MH - *Smartphone/statistics & numerical data MH - Child MH - Surveys and Questionnaires MH - Adolescent MH - *Screen Time MH - Self Report OTO - NOTNLM OT - Child health OT - Encuestas y cuestionarios OT - Media use OT - Mobile phone use OT - Public health OT - Salud infantil OT - Salud publica OT - Screen time OT - Surveys and questionnaires OT - Tiempo de pantalla OT - Uso de medios OT - Uso de telefono movil COIS- Declaration of competing interest The authors declare no conflicts of interest. EDAT- 2026/02/25 00:30 MHDA- 2026/03/17 00:33 CRDT- 2026/02/24 21:58 PHST- 2025/07/24 00:00 [received] PHST- 2025/11/10 00:00 [accepted] PHST- 2026/03/17 00:33 [medline] PHST- 2026/02/25 00:30 [pubmed] PHST- 2026/02/24 21:58 [entrez] AID - S2341-2879(26)00055-4 [pii] AID - 10.1016/j.anpede.2026.504156 [doi] PST - ppublish SO - An Pediatr (Engl Ed). 2026 Mar;104(3):504156. doi: 10.1016/j.anpede.2026.504156. Epub 2026 Feb 23. PMID- 41734444 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260710 IS - 1472-6491 (Electronic) IS - 1472-6483 (Linking) VI - 52 IP - 4 DP - 2026 Apr TI - Association between the adherence to different dietary patterns and sperm chromatin integrity in healthy men. PG - 105356 LID - S1472-6483(25)00563-2 [pii] LID - 10.1016/j.rbmo.2025.105356 [doi] AB - RESEARCH QUESTION: Are healthy and unhealthy diets associated with sperm DNA fragmentation and chromatin deprotamination in healthy men of reproductive age? DESIGN: A cross-sectional analysis conducted using healthy male volunteers (n = 200), aged 18-40 years, participating in the Led-Fertyl study. Adherence to five dietary patterns were estimated using a-priori indices: Mediterranean diet (Mediterranean Diet Adherence Screener; [MEDAS]); healthy and unhealthy plant-based diets; EAT-Lancet diet and Western diet. Dietary intake was assessed using a validated 143-item Food Frequency Questionnaire. Double-strand DNA fragmentation in spermatozoa evaluated by the Neutral Comet assay and chromatin deprotamination evaluated through chromomycin A3 (CMA3) staining by flow cytometry, were considered the main outcomes. RESULTS: No association between adherence to MEDAS, healthy and unhealthy plant-based, EAT-Lancet or Western dietary patterns with sperm DNA fragmentation was observed. Furthermore, adherence to MEDAS, healthy plant-based, EAT-Lancet or Western dietary patterns did not differ in sperm chromatin deprotamination. Yet, adherence to the unhealthy plant-based diet was non-linearly associated with increased chromatin deprotamination in all statistical models. Compared with the lowest tertile, participants in the highest unhealthy plant-based tertile had greater sperm chromatin deprotamination (beta = 12.4, 95% CI 2.7 to 22.1, P = 0.026), suggesting a higher occurrence of abnormalities in sperm chromatin condensation. CONCLUSION: To the best of our knowledge, this study is the first to epidemiologically investigate the relationship between dietary patterns and sperm chromatin integrity, highlighting that adherence to unhealthy plant-based diets may lead to sperm chromatin abnormalities. These findings underscore the potential effect of specific dietary patterns on molecular sperm quality parameters and support further research into dietary strategies for optimizing sperm integrity and improving male fertility. CI - Copyright (c) 2025 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Llavanera, Marc AU - Llavanera M AD - Laboratory of Chromosome Biology, Max Planck Institute of Biochemistry, DE-82152 Martinsried, Germany; Biotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of Girona, ES-17003 Girona, Spain. FAU - Fernandez de la Puente, Maria AU - Fernandez de la Puente M AD - Universitat Rovira i Virgili, Unitat de Nutricio Humana, Departament de Bioquimica i Biotecnologia. Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), ES-43201 Reus, Spain; Institut d'Investigacio Sanitaria Pere Virgili (IISPV), ES-43204 Reus, Spain; Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, ES-28029 Madrid, Spain. FAU - Davila-Cordova, Estefania AU - Davila-Cordova E AD - Universitat Rovira i Virgili, Unitat de Nutricio Humana, Departament de Bioquimica i Biotecnologia. Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), ES-43201 Reus, Spain; Institut d'Investigacio Sanitaria Pere Virgili (IISPV), ES-43204 Reus, Spain. FAU - Eigbefoh-Addeh, Ailende AU - Eigbefoh-Addeh A AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), ES-43204 Reus, Spain; Universitat Rovira i Virgili, Unit of Preventive Medicine and Biostatistics, Department of Basic Medical Sciences. Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), ES-43201 Reus, Spain. FAU - Agarwal, Rashmi AU - Agarwal R AD - Universitat Rovira i Virgili, Unitat de Nutricio Humana, Departament de Bioquimica i Biotecnologia. Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), ES-43201 Reus, Spain; Institut d'Investigacio Sanitaria Pere Virgili (IISPV), ES-43204 Reus, Spain. FAU - Valle-Hita, Cristina AU - Valle-Hita C AD - Universitat Rovira i Virgili, Unitat de Nutricio Humana, Departament de Bioquimica i Biotecnologia. Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), ES-43201 Reus, Spain; Institut d'Investigacio Sanitaria Pere Virgili (IISPV), ES-43204 Reus, Spain; Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, ES-28029 Madrid, Spain; Section of Epidemiology, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark. FAU - Babio, Nancy AU - Babio N AD - Universitat Rovira i Virgili, Unitat de Nutricio Humana, Departament de Bioquimica i Biotecnologia. Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), ES-43201 Reus, Spain; Institut d'Investigacio Sanitaria Pere Virgili (IISPV), ES-43204 Reus, Spain; Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, ES-28029 Madrid, Spain. FAU - Salas-Salvado, Jordi AU - Salas-Salvado J AD - Universitat Rovira i Virgili, Unitat de Nutricio Humana, Departament de Bioquimica i Biotecnologia. Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), ES-43201 Reus, Spain; Institut d'Investigacio Sanitaria Pere Virgili (IISPV), ES-43204 Reus, Spain; Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, ES-28029 Madrid, Spain; Catalan Institution for Research and Advanced Studies (ICREA), ES-08010 Barcelona, Spain. FAU - Yeste, Marc AU - Yeste M AD - Biotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of Girona, ES-17003 Girona, Spain; Universitat Rovira i Virgili, Unit of Preventive Medicine and Biostatistics, Department of Basic Medical Sciences. Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), ES-43201 Reus, Spain; Catalan Institution for Research and Advanced Studies (ICREA), ES-08010 Barcelona, Spain; Unit of Cell Biology, Department of Biology, Faculty of Sciences, University of Girona, ES-17003 Girona, Spain. FAU - Salas-Huetos, Albert AU - Salas-Huetos A AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), ES-43204 Reus, Spain; Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, ES-28029 Madrid, Spain; Universitat Rovira i Virgili, Unit of Preventive Medicine and Biostatistics, Department of Basic Medical Sciences. Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), ES-43201 Reus, Spain; Department of Nutrition, Harvard T.H. Chan School of Public Health, US-02115 Boston, Massachusetts, USA. Electronic address: albert.salas@urv.cat. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251020 PL - Netherlands TA - Reprod Biomed Online JT - Reproductive biomedicine online JID - 101122473 RN - 0 (Chromatin) SB - IM MH - Humans MH - Male MH - *Spermatozoa/metabolism MH - Adult MH - *Chromatin/metabolism MH - *DNA Fragmentation MH - Young Adult MH - Adolescent MH - Cross-Sectional Studies MH - Diet, Mediterranean MH - Diet, Western MH - Diet, Plant-Based MH - *Diet MH - Diet, Vegetarian OTO - NOTNLM OT - DNA fragmentation OT - Dietary patterns OT - Male fertility OT - Plant-based diet OT - Sperm chromatin integrity EDAT- 2026/02/25 00:29 MHDA- 2026/04/21 17:42 CRDT- 2026/02/24 18:02 PHST- 2025/06/05 00:00 [received] PHST- 2025/09/23 00:00 [revised] PHST- 2025/10/14 00:00 [accepted] PHST- 2026/04/21 17:42 [medline] PHST- 2026/02/25 00:29 [pubmed] PHST- 2026/02/24 18:02 [entrez] AID - S1472-6483(25)00563-2 [pii] AID - 10.1016/j.rbmo.2025.105356 [doi] PST - ppublish SO - Reprod Biomed Online. 2026 Apr;52(4):105356. doi: 10.1016/j.rbmo.2025.105356. Epub 2025 Oct 20. PMID- 41734092 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260708 IS - 1555-0273 (Electronic) IS - 1555-0265 (Linking) VI - 21 IP - 5 DP - 2026 May 1 TI - Reliability of 10- and 30-Second Tethered Swimming Tests in Highly Trained Swimmers: Influence of Swimming Specialty, Sex, Performance Level, and Evaluator. PG - 648-655 LID - 10.1123/ijspp.2025-0203 [doi] AB - PURPOSE: The tethered swimming test is relevant for the longitudinal monitoring of swimmers. However, for accurate interpretation of observed variations over time, understanding the reliability of the test and the factors influencing it is crucial. This study aimed to assess the absolute and relative reliability of parameters derived from 10- and 30-second front-crawl-tethered swimming tests by considering swimming specialty, sex, and performance level. Output variables resulting from manual stroke cycle segmentation were examined to evaluate interevaluator reliability. METHODS: Twenty-one highly trained swimmers performed the 2 specific time-based tests over 3 consecutive days. Relative and absolute reliability were assessed using the intraclass correlation coefficient and standard error of measurement, respectively. RESULTS: Mean force, peak force, and impulse demonstrated high reliability (intraclass correlation coefficient > .86 and .73 for 10- and 30-s tests, respectively). Fatigue index, performance decrement, and rate of performance decline exhibited varying reliability from poor to high. These results were unaffected by swimming specialty, sex, performance level, or evaluator. CONCLUSION: The findings indicate that 10- and 30-second front-crawl tethered swimming tests are highly reliable. Mean force, peak force, and impulse emerge as the most reliable parameters, regardless of the swimming specialty, sex, performance level, or evaluator. FAU - Couvertier, Marien AU - Couvertier M AUID- ORCID: 0009-0003-4212-6015 AD - Institut Prime, UPR 3346, CNRS-University of Poitiers-ISAE-ENSMA, Poitiers, France. FAU - Bretonneau, Quentin AU - Bretonneau Q AUID- ORCID: 0000-0002-9307-8688 AD - Laboratory MOVE-UR 20296-University of Poitiers, Poitiers, France. FAU - Monnet, Tony AU - Monnet T AUID- ORCID: 0000-0003-2942-2437 AD - Institut Prime, UPR 3346, CNRS-University of Poitiers-ISAE-ENSMA, Poitiers, France. FAU - Samson, Mathias AU - Samson M AD - Institut Prime, UPR 3346, CNRS-University of Poitiers-ISAE-ENSMA, Poitiers, France. FAU - Morales-Artacho, Antonio AU - Morales-Artacho A AD - Laboratory Sport, Expertise and Performance, INSEP, Paris, France. FAU - Pla, Robin AU - Pla R AUID- ORCID: 0000-0002-8504-5069 AD - Federation Francaise de Natation, Paris, France. FAU - Bosquet, Laurent AU - Bosquet L AUID- ORCID: 0000-0002-2530-2676 AD - Laboratory MOVE-UR 20296-University of Poitiers, Poitiers, France. FAU - Decatoire, Arnaud AU - Decatoire A AUID- ORCID: 0000-0003-1040-6162 AD - Institut Prime, UPR 3346, CNRS-University of Poitiers-ISAE-ENSMA, Poitiers, France. CN - D-Day Consortium LA - eng PT - Journal Article DEP - 20260223 PL - United States TA - Int J Sports Physiol Perform JT - International journal of sports physiology and performance JID - 101276430 SB - IM MH - *Swimming/physiology MH - Humans MH - Reproducibility of Results MH - *Athletic Performance/physiology MH - Male MH - Female MH - *Exercise Test/methods MH - Sex Factors MH - Young Adult MH - Time Factors MH - Adolescent MH - Biomechanical Phenomena OTO - NOTNLM OT - assessment OT - biomechanics OT - exercise training OT - force production EDAT- 2026/02/24 18:46 MHDA- 2026/05/01 12:37 CRDT- 2026/02/24 13:03 PHST- 2025/09/02 00:00 [received] PHST- 2025/12/11 00:00 [revised] PHST- 2026/01/06 00:00 [accepted] PHST- 2026/05/01 12:37 [medline] PHST- 2026/02/24 18:46 [pubmed] PHST- 2026/02/24 13:03 [entrez] AID - 10.1123/ijspp.2025-0203 [doi] PST - epublish SO - Int J Sports Physiol Perform. 2026 Feb 23;21(5):648-655. doi: 10.1123/ijspp.2025-0203. Print 2026 May 1. PMID- 41733754 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260710 IS - 1550-9397 (Electronic) IS - 1550-9389 (Print) IS - 1550-9389 (Linking) VI - 22 IP - 1 DP - 2026 Feb 24 TI - Initial validation of a pediatric cataplexy survey for children and adolescents with narcolepsy type 1. LID - 10.1007/s44470-026-00043-5 [doi] LID - 38 AB - PURPOSE: Cataplexy is core symptom of pediatric narcolepsy type 1 (NT1) but there is currently no validated cataplexy scale that captures the frequency, severity, and impact of cataplexy for children and adolescents to guide care. In this study, we developed and validated a 7-item Pediatric Cataplexy Scale (PCS). METHODS: We performed psychometric evaluation of the PCS using item response theory, specifically a graded response model (GRM). Sixty-nine children and adolescents with NT1 (age 9-21) from six North American sites completed the study. We examined the 7-item scale for internal consistency reliability (alpha, omega, marginal reliability), global and local model fit within the GRM framework, item discrimination and threshold ordering, convergent and divergent validity, and measurement invariance across sex. RESULTS: Internal consistency was strong using all three indicators. The freely estimated GRM provided superior fit over a Rasch-constrained model (p = 0.032) and excellent global fit indices (CFI = 0.996; TLI = 0.995; RMSEA = 0.041; SRMR = 0.041). Convergent validity was supported by significant correlations with the Narcolepsy Severity Scale (r = 0.459, p < 0.001) and the PedsQL Psychosocial Health Summary Score (r=-0.295, p = 0.014). Divergent validity was demonstrated through nonsignificant associations with the respiratory disturbance index and body mass index. Measurement invariance testing showed minimal non-invariance across sex, with no significant differences in latent means. CONCLUSION: The PCS shows desirable psychometric properties and can be used in clinical and research settings to assess cataplexy symptoms in NT1 youth. Current knowledge/Study rationale Cataplexy is a core symptom of pediatric narcolepsy type 1, yet no validated tool exists to measure its frequency, severity, and impact in children and adolescents. This gap limits clinicians' ability to assess symptom burden and guide treatment. Study impact In this study, we developed and validated the 7-item Pediatric Cataplexy Scale (PCS) using rigorous item response theory methods across a multi-site NT1 cohort. The PCS demonstrated strong internal consistency, excellent model fit, and appropriate convergent, divergent, and sex-invariant properties, supporting its reliability and validity. This scale offers the first psychometrically robust cataplexy measure to use in youth with NT1, enabling standardized symptom assessment in both clinical care and research. FAU - Maski, Kiran AU - Maski K AUID- ORCID: 0000-0003-4073-4036 AD - Department of Neurology, Boston Children's Hospital, Boston, MA, USA. kiran.maski@childrens.harvard.edu. FAU - Mignot, Emmanuel AU - Mignot E AD - Stanford Center for Sleep Sciences and Medicine, Redwood City, CA, USA. FAU - Wang, Grace Y AU - Wang GY AD - Department of Neurology, Boston Children's Hospital, Boston, MA, USA. FAU - Narang, Indra AU - Narang I AD - Division of Respiratory Medicine, Hospital for Sick Children, Toronto, ON, Canada. AD - Department of Pediatrics, University of Toronto, Toronto, ON, Canada. AD - Translational Medicine, Research Institute, The Hospital for Sick Children-SickKids, Toronto, ON, Canada. FAU - Worhach, Jennifer AU - Worhach J AD - Department of Neurology, Boston Children's Hospital, Boston, MA, USA. FAU - Strunc, Michael AU - Strunc M AD - Department of Neurology, Children's Hospital of the King's Daughter, Norfolk, VA, USA. FAU - Morse, Anne M AU - Morse AM AD - Department of Child Neurology and Pediatric Sleep Medicine, Janet Weis Children's Hospital, Geisinger Medical Center, Danville, PA, USA. FAU - Flygare, Julie AU - Flygare J AD - Project Sleep, Los Angeles, CA, USA. FAU - Sideridis, Georgios AU - Sideridis G AD - Biostatistics and Research Design Center, Boston Children's Hospital, Boston, MA, USA. FAU - Meltzer, Lisa J AU - Meltzer LJ AD - Department of Pediatrics, National Jewish Health, Denver, CO, USA. LA - eng GR - Wake Up Narcolepsy/Wake Up Narcolepsy/ GR - American Sleep Medicine Foundation/American Sleep Medicine Foundation/ PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20260224 PL - Switzerland TA - J Clin Sleep Med JT - Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine JID - 101231977 RN - Narcolepsy 1 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - Child MH - *Narcolepsy/diagnosis/complications MH - Psychometrics MH - Reproducibility of Results MH - Surveys and Questionnaires MH - *Cataplexy/diagnosis MH - Young Adult MH - Severity of Illness Index PMC - PMC12994973 OTO - NOTNLM OT - Adolescent OT - Cataplexy OT - Children OT - Narcolepsy OT - Patient-reported outcomes OT - Pediatrics OT - Questionnaire OT - Survey OT - Validation OT - Youth COIS- Declarations. Ethics approval and consent to participate: The Boston Children's Hospital Institutional Review Board reviewed and approved study procedures (protocol number P00029346) and each site received their own IRB approval for data collection. The participating parent/guardian provided informed consent, and the child/adolescent participant gave their assent. Consent: All authors provide consent for publication. Competing Interests: Dr. Kiran Maski has been a consultant for Takeda Pharmaceuticals, Jazz Pharmaceuticals, Alkermes, Avadel, Eisai Pharmaceuticals, Synchronicity, Taysha Gene Therapies, and Harmony Biosciences. She has received research funding from Jazz Pharmaceuticals and Harmony Biosciences and is a collaborator for a clinical trial funded by Takeda Pharmaceuticals. Dr. Emmanuel Mignot has received research support from Apple, Jazz Pharmaceuticals, Takeda, Merck, GlaxoSmithKline, and Sunovion; is a consultant for Dreem, Alairion, Orexia, and Inexia; and is on the speakers' bureau for Vox Media. EDAT- 2026/02/24 18:46 MHDA- 2026/06/27 10:10 PMCR- 2027/02/24 CRDT- 2026/02/24 11:18 PHST- 2025/11/17 00:00 [received] PHST- 2026/01/06 00:00 [accepted] PHST- 2026/01/05 00:00 [revised] PHST- 2026/06/27 10:10 [medline] PHST- 2026/02/24 18:46 [pubmed] PHST- 2026/02/24 11:18 [entrez] PHST- 2027/02/24 00:00 [pmc-release] AID - 10.1007/s44470-026-00043-5 [pii] AID - 43 [pii] AID - 10.1007/s44470-026-00043-5 [doi] PST - epublish SO - J Clin Sleep Med. 2026 Feb 24;22(1):38. doi: 10.1007/s44470-026-00043-5. PMID- 41731444 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Feb 23 TI - The mediating role of physical activity enjoyment in the relationship between physical activity and subjective well-being among adolescents. LID - 10.1186/s12889-026-26676-y [doi] LID - 1051 AB - BACKGROUND: Physical activity (PA) has been associated with subjective well-being (SWB) among adolescents. However, the processes underlying this association, particularly the role of physical activity enjoyment (PAE) in PA, have been less explored. This study aimed to examine the associations among PA, PAE, and SWB among Chinese adolescents. METHODS: A cross-sectional study was conducted among 947 students recruited from two junior high school and two senior high schools in a city in Shanxi Province, China. Participants completed validated questionnaires assessing PA, PAE, and SWB. Using the SPSS macro PROCESS, a mediation model was tested with PA as the independent variable, SWB as the dependent variable, and PAE as the mediator while controlling for gender and grade. The bootstrap method was employed to examine the significance of the mediating effect. RESULTS: Mediation analysis revealed that PA was a significant positive predictor of both PAE (beta = 0.529, P < 0.001) and SWB (beta = 0.147, P < 0.001). However, when PAE was included in the model, the direct effect of PA on SWB became nonsignificant. Bootstrap results (based on 5000 samples) confirmed that the direct effect was not significant (beta = -0.010, 95% CI [-0.039, 0.031]), whereas the indirect effect through PAE was significant (beta = 0.157, 95% CI [0.110, 0.209]). CONCLUSION: PAE mediates the relationship between PA and SWB in adolescents. These findings highlight the potential importance of promoting enjoyable PA experiences to support adolescent well-being. FAU - Peng, Jiale AU - Peng J AD - School of Physical Education, Guangdong University of Education, Guangzhou, 510303, China. AD - School of Sport Science, Beijing Sport University, Beijing, 100084, China. FAU - Yu, Wenlang AU - Yu W AD - School of Sport Science, Beijing Sport University, Beijing, 100084, China. FAU - Yan, Wenjing AU - Yan W AD - Shanxi Normal University, Taiyuan, Shanxi, 030031, China. FAU - Zheng, Bin AU - Zheng B AD - General Hospital of Northern Theater Command, Shenyang, 110003, China. xyxxzb@126.com. LA - eng GR - 2024JH2/102600270/Liaoning Provincial Science and Technology Plan Joint Program (Technology Research and Development Project)/ PT - Journal Article DEP - 20260223 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Adolescent MH - *Psychological Well-Being MH - Male MH - Cross-Sectional Studies MH - Female MH - *Exercise/psychology MH - China MH - Surveys and Questionnaires MH - *Pleasure PMC - PMC13036990 OTO - NOTNLM OT - Adolescents OT - Enjoyment of physical activity OT - Physical activity OT - Subjective well-being COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki. The study was approved by the Ethics Committee for Sports Science Experiments of Beijing Sport University (Approval No. 2020128 H). Informed consent to participate was obtained from the parents or legal guardians through the school administration prior to data collection. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/24 00:30 MHDA- 2026/06/27 12:36 PMCR- 2026/02/23 CRDT- 2026/02/23 23:57 PHST- 2025/10/06 00:00 [received] PHST- 2026/02/11 00:00 [accepted] PHST- 2026/06/27 12:36 [medline] PHST- 2026/02/24 00:30 [pubmed] PHST- 2026/02/23 23:57 [entrez] PHST- 2026/02/23 00:00 [pmc-release] AID - 10.1186/s12889-026-26676-y [pii] AID - 26676 [pii] AID - 10.1186/s12889-026-26676-y [doi] PST - epublish SO - BMC Public Health. 2026 Feb 23;26(1):1051. doi: 10.1186/s12889-026-26676-y. PMID- 41729314 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1591-9528 (Electronic) IS - 1591-8890 (Print) IS - 1591-8890 (Linking) VI - 26 IP - 1 DP - 2026 Feb 23 TI - Early detection and risk stratification of insulin resistance in children and adolescents with excess weight: a sdLDL/oxLDL-Based model. LID - 10.1007/s10238-026-02089-4 [doi] LID - 163 AB - Childhood excess weight is a significant risk factor for insulin resistance (IR), a key precursor to metabolic syndrome and type 2 diabetes. In epidemiologic studies, IR is commonly assessed by the homeostatic model assessment for insulin resistance (HOMA-IR). This study aimed to develop a small dense low-density lipoprotein (sdLDL) and oxidized low-density lipoprotein (oxLDL)-based model for the early detection and risk stratification of HOMA-IR-defined IR in children and adolescents with excess weight. A total of 510 children and adolescents with excess weight (aged 7-17 years) were enrolled and stratified into IR (n = 173) and non-IR (n = 337) groups according to HOMA-IR. Comprehensive anthropometric and biochemical parameters were collected, including comparative analyses of sdLDL, oxLDL, and triglyceride to high-density lipoprotein cholesterol (TG/HDL) ratio. Independent risk factors were identified through univariate and multivariate logistic regression, followed by development of a nomogram prediction model incorporating three lipid parameters and adjusted for age and sex. Model performance was evaluated using receiver operating characteristic curves, calibration analysis with bootstrap internal validation and decision curve analysis (DCA). Univariate analysis identified significant associations between IR and mean arterial pressure, TG/HDL, total cholesterol to HDL (TC/HDL) ratio, LDL to HDL (LDL/HDL) ratio, oxLDL, and sdLDL (all P < 0.05). Multivariate analysis confirmed TG/HDL (adjusted odds ratio [aOR] = 5.61, 95% confidence interval [CI]: 3.060-10.639, P < 0.001), oxLDL (aOR = 1.092, 95% CI: 1.065-1.120, P < 0.001), and sdLDL (aOR = 1.109, 95% CI: 1.076-1.146, P < 0.001) as independent risk factors. The final age- and sex-adjusted nomogram demonstrated strong discrimination (AUC = 0.836), good calibration (bootstrap-corrected mean absolute error = 0.012), and clear net clinical benefit across a wide range of decision thresholds based on DCA. Probability-based stratification enabled both continuous scoring and visual classification of individual IR risk. The developed age- and sex-adjusted nomogram combining TG/HDL ratio, sdLDL, and oxLDL demonstrates superior performance for predicting IR in children and adolescents with excess weight. By integrating continuous risk scoring with clinically actionable risk stratification, this tool supports early identification and tiered management in both screening and clinical decision-making settings. CI - (c) 2026. The Author(s). FAU - Zhao, YaJie AU - Zhao Y AD - School of Medical Laboratory Technology, Xinyang Vocational and Technical College, No.48, New 24th Street, Pingqiao District, Xinyang City, 464000, Henan Province, China. FAU - Zhu, ZhaoYu AU - Zhu Z AD - School of Medical Laboratory Technology, Xinyang Vocational and Technical College, No.48, New 24th Street, Pingqiao District, Xinyang City, 464000, Henan Province, China. FAU - Hu, WenTan AU - Hu W AD - Department of Clinical Laboratory, Xinyang Central Hospital, Xinyang City, 464000, Henan Province, China. FAU - Li, Ju AU - Li J AD - School of Medical Laboratory Technology, Xinyang Vocational and Technical College, No.48, New 24th Street, Pingqiao District, Xinyang City, 464000, Henan Province, China. zyjliju@hotmail.com. LA - eng PT - Journal Article DEP - 20260223 PL - Italy TA - Clin Exp Med JT - Clinical and experimental medicine JID - 100973405 RN - 0 (Lipoproteins, LDL) RN - 0 (oxidized low density lipoprotein) SB - IM MH - Humans MH - *Lipoproteins, LDL/blood MH - Child MH - Adolescent MH - Female MH - *Insulin Resistance MH - Male MH - Early Diagnosis MH - Risk Factors MH - Risk Assessment MH - ROC Curve MH - *Overweight/complications PMC - PMC12932282 OTO - NOTNLM OT - Insulin resistance OT - Lipid metabolism OT - OxLDL OT - Pediatric obesity OT - Risk stratification OT - SdLDL OT - TG/HDL ratio COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval: The present study was approved by the Ethics Committee of Xinyang Central Hospital (No.202103XY66) and written informed consent was provided by all parents or guardians of the patients prior to the study start. All procedures were performed in accordance with the ethical standards of the Institutional Review Board and The Declaration of Helsinki, and its later amendments or comparable ethical standards. EDAT- 2026/02/23 13:06 MHDA- 2026/02/26 06:58 PMCR- 2026/02/23 CRDT- 2026/02/23 11:16 PHST- 2025/07/30 00:00 [received] PHST- 2026/02/03 00:00 [accepted] PHST- 2026/02/26 06:58 [medline] PHST- 2026/02/23 13:06 [pubmed] PHST- 2026/02/23 11:16 [entrez] PHST- 2026/02/23 00:00 [pmc-release] AID - 10.1007/s10238-026-02089-4 [pii] AID - 2089 [pii] AID - 10.1007/s10238-026-02089-4 [doi] PST - epublish SO - Clin Exp Med. 2026 Feb 23;26(1):163. doi: 10.1007/s10238-026-02089-4. PMID- 41727210 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260223 LR - 20260813 IS - 2054-3581 (Print) IS - 2054-3581 (Electronic) IS - 2054-3581 (Linking) VI - 13 DP - 2026 TI - Integrating the Novel iCARE Estimated Glomerular Filtration Rate Equation for Youth Living With Type 2 Diabetes Into Care: Program Report. PG - 20543581251413452 LID - 10.1177/20543581251413452 [doi] LID - 20543581251413452 AB - PURPOSE OF THE PROGRAM: Youth living with type 2 diabetes (T2D) have high rates of early kidney disease and progression to kidney failure in early adulthood. Pediatric diabetes clinical practice guidelines have focused on screening for albuminuria and have not included recommendations for estimated glomerular filtration rate (eGFR) evaluation in children. In partnership with patients, families, and community partners, we are implementing a novel eGFR equation for youth with T2D into their diabetes care, with the aim of detecting youth with early kidney disease and providing appropriate interventions to slow disease progression. SOURCES OF INFORMATION: The development of such a tool aligned with a priority-setting workshop in 2016, where early detection and prevention of kidney disease were identified as a key priority by people living with kidney disease. In response, our team developed the novel Improving renal Complications in Adolescents with type 2 diabetes through Research (iCARE) eGFR equation, which estimates kidney function over time in youth with T2D, and validated it in a cohort of youth in Colorado (US) and a secondary group of youth in Manitoba (Canada). METHODS: To integrate the tool into clinical care, this study includes 4 separate phases. Phase 1: External validation of the iCARE eGFR equation in a cohort of children with obesity and T2D from Colorado, US, to assess the generalizability of the equation. Phase 2: Readiness Assessment of pediatric endocrinologists (a) quantitative survey in Canada (n = 40) and the United States (n = 75) to assess current practice for screening youth with T2D for diabetic kidney disease (DKD) and (b) qualitative focus groups (4 groups; 2 in Canada [n = 8] and 2 in the United States [n = 5]) to explore barriers and facilitators to implementation of the iCARE eGFR equation into the care for youth with T2D. Focus groups of youth living with T2D are underway and explore how youth and families wish to be educated regarding kidney health and what sources of information would be helpful to empower youth to ask about kidney health in clinical settings. Phase 3: Development and implementation of an iCARE eGFR equation toolkit, which will include the resources for providers and patient education materials and the inclusion of the novel eGFR equation into an app and local electronic medical record systems at 3 sites (Vancouver, Winnipeg, Toronto). Phase 4: Evaluation of the iCARE eGFR implementation toolkit, including audits at 3 centers in Canada, as well as patient and provider satisfaction surveys. KEY FINDINGS: Phase 1: The validation study confirmed that the iCARE eGFR performed better than previously published eGFR equations in youth living with obesity and T2D. Relevant metrics were the highest P30 (% of eGFR values that fall within 30% of the measured glomerular filtration rate [GFR]) and the lowest bias. Phase 2: Survey results suggest that providers have strong adherence to existing T2D clinical practice guidelines, focused on albuminuria, but have limited experience and comfort with eGFR equations in general. Focus group discussions identified concerns about insufficient evidence indicating that eGFR metrics in childhood are associated with long-term outcomes and questions about generalizability and external validity. Key facilitators for improving uptake included development of a more comprehensive app or platform that presents eGFR findings in an accessible way for endocrinologists and development of clinical pathway guidelines to support follow-up treatment. IMPLICATIONS: Findings from phases 1 and 2 will be incorporated into the iCARE eGFR implementation toolkit, such that care providers and patients are able to utilize the most up-to-date evidence to screen for DKD and implement care strategies that will optimize the long-term kidney health of youth living with T2D. CI - (c) The Author(s) 2026. FAU - Dart, Allison B AU - Dart AB AUID- ORCID: 0000-0002-4718-9408 AD - Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. AD - DREAM Research Theme, Children's Hospital Research Institute of Manitoba, Winnipeg, Canada. FAU - Zhou, J Grace AU - Zhou JG AUID- ORCID: 0000-0003-4201-0699 AD - DREAM Research Theme, Children's Hospital Research Institute of Manitoba, Winnipeg, Canada. FAU - Sellers, Elizabeth A C AU - Sellers EAC AD - Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. AD - DREAM Research Theme, Children's Hospital Research Institute of Manitoba, Winnipeg, Canada. FAU - Hamilton, Jill AU - Hamilton J AD - Department of Paediatrics, University of Toronto, Canada. FAU - Basak, Sanjukta AU - Basak S AD - Department of Pediatrics, University of British Columbia, Vancouver, Canada. FAU - Ryan, Paul AU - Ryan P AD - Department of Paediatrics, University of Toronto, Canada. FAU - Garcia Acevedo, Giliana P AU - Garcia Acevedo GP AD - Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. FAU - Hunt, Brianna AU - Hunt B AD - DREAM Research Theme, Children's Hospital Research Institute of Manitoba, Winnipeg, Canada. FAU - Del Vecchio, Melissa AU - Del Vecchio M AD - DREAM Research Theme, Children's Hospital Research Institute of Manitoba, Winnipeg, Canada. FAU - Lopez, Jennifer AU - Lopez J AD - iCARE Study, DREAM Research Theme and Can-SOLVE CKD, Winnipeg, MB, Canada. FAU - Alecio-Garcia, Onalee AU - Alecio-Garcia O AD - iCARE Study, DREAM Research Theme and Can-SOLVE CKD, Winnipeg, MB, Canada. FAU - Onyiuke, Chukwudumebi AU - Onyiuke C AD - Four Arrow Regional Health Authority, Winnipeg, MB, Canada. FAU - Linklater, Jacqueline AU - Linklater J AD - Four Arrow Regional Health Authority, Winnipeg, MB, Canada. FAU - Umaefulam, Valerie AU - Umaefulam V AUID- ORCID: 0000-0003-4239-7715 AD - George and Faye Centre for Healthcare Innovation, College of Community and Global Health, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. FAU - Tommerdahl, Kalie AU - Tommerdahl K AUID- ORCID: 0000-0003-1132-1574 AD - Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, USA. FAU - Bjornstad, Petter AU - Bjornstad P AD - Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, USA. FAU - Wicklow, Brandy A AU - Wicklow BA AD - Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. AD - DREAM Research Theme, Children's Hospital Research Institute of Manitoba, Winnipeg, Canada. LA - eng PT - Journal Article DEP - 20260218 PL - England TA - Can J Kidney Health Dis JT - Canadian journal of kidney health and disease JID - 101640242 PMC - PMC12921172 OTO - NOTNLM OT - eGFR OT - evaluation OT - knowledge mobilization OT - type 2 diabetes OT - youth COIS- The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/02/23 13:05 MHDA- 2026/02/23 13:06 PMCR- 2026/02/18 CRDT- 2026/02/23 06:34 PHST- 2025/12/09 00:00 [received] PHST- 2025/12/17 00:00 [accepted] PHST- 2026/02/23 13:06 [medline] PHST- 2026/02/23 13:05 [pubmed] PHST- 2026/02/23 06:34 [entrez] PHST- 2026/02/18 00:00 [pmc-release] AID - 10.1177_20543581251413452 [pii] AID - 10.1177/20543581251413452 [doi] PST - epublish SO - Can J Kidney Health Dis. 2026 Feb 18;13:20543581251413452. doi: 10.1177/20543581251413452. eCollection 2026. PMID- 41725550 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260706 IS - 1473-0804 (Electronic) IS - 1369-7137 (Linking) VI - 29 IP - 3 DP - 2026 Jun TI - Hot flashes: a potential marker of deterioration of health-related quality of life. PG - 462-469 LID - 10.1080/13697137.2026.2627561 [doi] AB - OBJECTIVE: Hot flashes are among the most common symptoms of the menopausal transition and have traditionally been considered benign and self-limiting. However, increasing evidence suggests that they may indicate broader neurovascular and inflammatory dysregulation linked to reproductive aging. The possible effect of hot flush severity on health-related quality of life (HRQoL) remains inadequately studied, particularly in Latin American populations. This study aimed to examine the association between hot flash severity and HRQoL in middle-aged women using validated tools and a large, multicenter sample. METHOD: A cross-sectional study was conducted between June 2024 and January 2025 in 30 healthcare centers across 12 Latin American countries. A total of 3523 women aged 40-60 years were assessed using the Menopause Rating Scale (MRS) to evaluate vasomotor symptoms and the Short Form-36 Health Survey (SF-36) to measure HRQoL. Multivariable logistic regression models were utilized to estimate the association between hot flush severity and low HRQoL, adjusting for sociodemographic, behavioral and clinical covariates. RESULTS: Increasing severity of hot flushes was significantly associated with lower HRQoL scores across all SF-36 domains. In the logistic regression analysis, mild hot flushes (MRS item 1 score = 1) were associated with increased odds of impaired HRQoL (odds ratio [OR] 1.29; 95% confidence interval [CI]: 1.08-1.55), whereas very severe symptoms (MRS item 1 score = 4) demonstrated a substantially stronger association (OR 4.10; 95% CI: 2.93-5.74). Additional factors significantly associated with lower HRQoL included physical inactivity, the presence of comorbidities, obesity, current use of psychotropic medication, age >/=50 years and having two or more children. CONCLUSION: Hot flush severity is a strong and independent determinant of HRQoL in midlife women. These findings underscore the need for systematic assessment and targeted management of vasomotor symptoms in routine care, supporting the hypothesis that hot flashes may be a clinical marker of systemic aging. FAU - Blumel, Juan E AU - Blumel JE AD - Departamento de Medicina Interna Sur, Facultad de Medicina, Universidad de Chile, Santiago de Chile, Chile. FAU - Vallejo, Maria S AU - Vallejo MS AD - Servicio de Ginecologia y Obstetricia, Hospital Clinico, Universidad de Chile, Santiago de Chile, Chile. FAU - Chedraui, Peter AU - Chedraui P AD - Escuela de Postgrado en Salud, Universidad Espiritu Santo, Samborondon, Ecuador. FAU - Arteaga, Eugenio AU - Arteaga E AD - Departamento de Endocrinologia y CETREN, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago de Chile, Chile. FAU - Ayala, Felix AU - Ayala F AD - Departamento de Ginecologia y Obstetricia, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Peru. FAU - Bencosme, Ascanio AU - Bencosme A AD - Facultad de Ciencias de la Salud, Universidad Autonoma de Santo Domingo, Santo Domingo, Republica Dominicana. FAU - Calle, Andres AU - Calle A AD - Centro Integral de Salud Obstetrica y Femenina. Facultad de Ciencias de la Salud, Universidad Indoamerica, Academia Ecuatoriana de Medicina, Quito, Ecuador. FAU - Costa-Paiva, Lucia AU - Costa-Paiva L AD - Department of Obstetrics and Gynecology, Universidade Estadual de Campinas, Campinas, Brazil. FAU - Dextre, Maribel AU - Dextre M AD - Ginecologia y Obstetricia, Clinica Internacional, Lima, Peru. FAU - Diaz, Karen AU - Diaz K AD - Centro Ciudad Mujer, Ministerio de Salud, Asuncion, Paraguay. FAU - Elizalde-Cremonte, Alejandra AU - Elizalde-Cremonte A AD - Departamento de la Mujer, Ninez y Adolescencia, Facultad de Medicina, de la Universidad Nacional del Nordeste, Corrientes, Argentina. FAU - Elizalde-Cremonte, Santiago AU - Elizalde-Cremonte S AD - Departamento de la Mujer, Ninez y Adolescencia, Facultad de Medicina, de la Universidad Nacional del Nordeste, Corrientes, Argentina. FAU - Escalante, Carlos AU - Escalante C AD - Departamento de Ginecologia, Facultad de Medicina, Universidad de Costa Rica, San Jose, Costa Rica. FAU - Espinoza, Maria T AU - Espinoza MT AD - Unidad de Menopausia y Climaterio, Clinica Los Angeles, Cochabamba, Bolivia. FAU - Garcia, Ircania AU - Garcia I AD - Centro Medico Moderno, Santo Domingo, Republica Dominicana. FAU - Gomez-Tabares, Gustavo AU - Gomez-Tabares G AD - Unidad de Medicina Reproductiva, Clinica Imbanaco, Universidad del Valle, Cali, Colombia. FAU - Gutierrez-Crespo, Hugo AU - Gutierrez-Crespo H AD - Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Peru. FAU - Lopez, Marcela AU - Lopez M AD - Departamento de Ginecologia y Obstetricia, Facultad de Medicina, Universidad de Santiago, Santiago de Chile, Chile. FAU - Matsumura-Kasana, Juan AU - Matsumura-Kasana J AD - Unidad de Investigacion, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Peru. FAU - Meza, Paolo AU - Meza P AD - Medicina Familiar, Hospital Nacional Cayetano Heredia, Lima, Peru. FAU - Monterrosa-Castro, Alvaro AU - Monterrosa-Castro A AD - Grupo de Investigacion Salud de la Mujer, Universidad de Cartagena, Cartagena, Colombia. FAU - Nanez, Monica AU - Nanez M AD - II Catedra de Ginecologia, Universidad Nacional de Cordoba, Cordoba, Argentina. FAU - Ojeda, Eliana AU - Ojeda E AD - Departamento Academico de Medicina Humana, Universidad Andina del Cusco, Cusco, Peru. FAU - Rey, Claudia AU - Rey C AUID- ORCID: 0000-0002-0853-300X AD - Asociacion Argentina para el Estudio del Climaterio, Buenos Aires, Argentina. FAU - Valadares, Ana Lucia Ribeiro AU - Valadares ALR AD - Universidade Estadual de Campinas (UNICAMP), Campinas, Sao Paulo, Brasil. FAU - Rodriguez-Vidal, Doris AU - Rodriguez-Vidal D AD - Hospital de Clinicas Jose de San Martin, Universidad de Buenos Aires, Buenos Aires, Argentina. FAU - Rodrigues, Marcio Ah AU - Rodrigues MA AD - Department of Gynecology and Obstetrics, Federal University of Minas Gerais, Belo Horizonte, Brazil. FAU - Saavedra, Javier AU - Saavedra J AD - Departamento de Medicina Interna, Facultad de Medicina, Universidad Mayor de San Simon, Cochabamba, Bolivia. FAU - Salinas, Carlos AU - Salinas C AD - Servicio de Obstetricia y Ginecologia, Hospital Angeles, Puebla, Mexico. FAU - Sosa, Lida AU - Sosa L AD - Servicio de Ginecologia, Hospital Central del Instituto de Prevision Social, Asuncion, Paraguay. FAU - Tserotas, Konstantinos AU - Tserotas K AD - Clinica Tserotas, y Departamento de Ginecologia y Obstetricia Hospital Paitilla, Ciudad de Panama, Panama. FAU - Acuna-San Martin, Margot AU - Acuna-San Martin M AD - Departamento de Obstetricia y Ginecologia, Facultad de Medicina, Universidad de la Frontera (UFRO), Temuco, Chile. FAU - Aguirre, Marcela S AU - Aguirre MS AD - Departamento de Climaterio, Hospital Escuela Eva Peron, Granadero Baigorria, Santa Fe, Argentina. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260223 PL - England TA - Climacteric JT - Climacteric : the journal of the International Menopause Society JID - 9810959 SB - IM MH - Humans MH - *Hot Flashes/psychology/physiopathology MH - *Quality of Life MH - Female MH - Middle Aged MH - Cross-Sectional Studies MH - Adult MH - Severity of Illness Index MH - *Menopause/physiology MH - Surveys and Questionnaires OAB - Hot flashes are one of the most common symptoms that women experience during midlife. They are often regarded as a temporary and harmless symptom. However, updated research indicates that frequent or severe hot flashes could signal broader changes in the body, impacting blood vessels, the brain and aging. In the present study, more than 3500 women (aged 40-60 years) from 12 Latin American countries participated. They completed questionnaires that assessed hot flash severity and their health-related quality of life (HRQoL) in domains such as physical health, emotional well-being, energy and daily activities. We found that women experiencing more severe hot flashes were significantly more likely to report a lower HRQoL, even after considering confounding factors such as age, body mass index, medical conditions and lifestyle. Severe hot flashes nearly doubled the likelihood of poor HRQoL. Conversely, women currently using menopausal hormone therapy had a reduced risk of poor HRQoL. These findings indicate that hot flushes are not only unpleasant but can also significantly affect women's health and everyday life. Healthcare professionals should pay close attention to hot flushes and assist women in finding effective management strategies, as they may also signal overall aging and health concerns. OABL- eng OTO - NOTNLM OT - Hot flushes OT - health OT - menopausal hormone therapy OT - obesity OT - physical inactivity OT - quality of life EDAT- 2026/02/23 06:27 MHDA- 2026/06/23 12:34 CRDT- 2026/02/23 05:13 PHST- 2026/06/23 12:34 [medline] PHST- 2026/02/23 06:27 [pubmed] PHST- 2026/02/23 05:13 [entrez] AID - 10.1080/13697137.2026.2627561 [doi] PST - ppublish SO - Climacteric. 2026 Jun;29(3):462-469. doi: 10.1080/13697137.2026.2627561. Epub 2026 Feb 23. PMID- 41725310 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1097-0258 (Electronic) IS - 0277-6715 (Print) IS - 0277-6715 (Linking) VI - 45 IP - 3-5 DP - 2026 Feb TI - Modelling and Predicting Population-Level Growth With Individual-Level Information. PG - e70421 LID - 10.1002/sim.70421 [doi] LID - e70421 AB - The development of height, weight, and body mass index (BMI) in children has been the subject of considerable interest due to secular changes in growth patterns, such as increases in height and rising obesity rates. Predicting growth in a target population is particularly challenging when the population comprises of individuals with and without past growth data. In this study, we present three approaches for the joint prediction of height and weight in that situation. The predictive performance of each approach is evaluated using a range of measures that assess different properties of the prediction distributions. We also compare the approaches to interpret their clinical relevance, particularly in terms of prediction accuracy. The developed prediction approaches vary in their use of past growth data. We predict growth for a target population of children aged 4-11 years in 2021, residing in three municipalities in Finland. We employ longitudinal register data on height and weight, collected from children aged 2-11 years between 2014 and 2020 in these municipalities to construct a Bayesian hierarchical linear model (HLM) for growth prediction. Additionally, we estimate posterior unconditional distributions of height, weight, and BMI for within-sample model validation. The inclusion of individual-level data in the predictions reduced the divergence from observed measurements, particularly for weight and BMI. This is important given the skewed distribution of the measurements with increasing age. Incorporating individual-level information is also beneficial for child-specific predictions. Our study highlights the importance of multiple prediction checks to understand the flaws and strengths of each prediction approach. CI - (c) 2026 The Author(s). Statistics in Medicine published by John Wiley & Sons Ltd. FAU - Kauppala, Tuuli AU - Kauppala T AUID- ORCID: 0009-0004-1233-0055 AD - Department of Data and Analytics, Finnish Institute for Health and Welfare, Helsinki, Finland. AD - Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland. FAU - Susi, Tuomo AU - Susi T AD - Department of Data and Analytics, Finnish Institute for Health and Welfare, Helsinki, Finland. AD - Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland. FAU - Kulathinal, Sangita AU - Kulathinal S AUID- ORCID: 0000-0002-4542-8460 AD - Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland. LA - eng PT - Journal Article PL - England TA - Stat Med JT - Statistics in medicine JID - 8215016 SB - IM MH - Humans MH - Child, Preschool MH - Child MH - Bayes Theorem MH - Body Mass Index MH - *Body Height MH - *Body Weight MH - Finland MH - Linear Models MH - *Models, Statistical MH - Female MH - Male MH - Prediction Algorithms MH - *Population Growth MH - Longitudinal Studies PMC - PMC12926727 OTO - NOTNLM OT - Bayesian prediction OT - bivariate hierarchical model OT - growth modeling OT - growth prediction OT - hierarchical linear model COIS- The authors declare no conflicts of interest. EDAT- 2026/02/23 06:27 MHDA- 2026/02/23 06:28 PMCR- 2026/02/23 CRDT- 2026/02/23 02:43 PHST- 2025/12/12 00:00 [revised] PHST- 2025/01/28 00:00 [received] PHST- 2026/01/19 00:00 [accepted] PHST- 2026/02/23 06:28 [medline] PHST- 2026/02/23 06:27 [pubmed] PHST- 2026/02/23 02:43 [entrez] PHST- 2026/02/23 00:00 [pmc-release] AID - SIM70421 [pii] AID - 10.1002/sim.70421 [doi] PST - ppublish SO - Stat Med. 2026 Feb;45(3-5):e70421. doi: 10.1002/sim.70421. PMID- 41724965 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260627 LR - 20260813 IS - 1743-7075 (Print) IS - 1743-7075 (Electronic) IS - 1743-7075 (Linking) VI - 23 IP - 1 DP - 2026 Feb 22 TI - Skin carotenoids indicate diet, serum carotenoids, and inflammation across obesity and metabolic status in children. LID - 10.1186/s12986-026-01075-7 [doi] LID - 41 AB - OBJECTIVES: To validate reflection spectroscopy (RS)-based skin carotenoids (SCS) as non-invasive biomarkers of fruit and vegetable intake (FVI) in children and adolescents with obesity and metabolic dysfunction. METHODS: This case-control study (China, 2023) included 210 children and adolescents aged 7-17 years, categorized into five groups: healthy weight (n = 30), overweight (n = 23), obesity (n = 25), obesity with one metabolic disorder (n = 56), and obesity with two or more metabolic disorders (n = 76). SCS levels were measured using RS, FVI was assessed via a food frequency questionnaire, serum carotenoids were quantified by high-performance liquid chromatography, and inflammatory markers were analyzed using flow cytometry. RESULTS: SCS and serum carotenoid levels decreased significantly across groups (p for trend < 0.001). SCS correlated strongly with serum carotenoids, except for lycopene, with the strongest association observed in children and adolescents with obesity and two or more metabolic disorders. A quartile increase in FVI resulted in an 11.92-45.98 unit increase in SCS, partially mediated by total serum carotenoids, beta-carotene, and beta-cryptoxanthin. SCS also inversely correlated with inflammation in metabolically disordered groups. CONCLUSIONS: RS-based SCS is a valid, non-invasive biomarker of FVI, closely related to serum carotenoids and inflammatory status, and effectively distinguishes metabolic dysfunction in children and adolescents. FAU - Liu, Yang AU - Liu Y AD - Health Sciences Institute, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning, China. AD - Liaoning Key Laboratory of Obesity and Glycolipid Metabolic Diseases, Puhe Rd.77, Shenyang, 110122, Liaoning, China. FAU - Huang, Huihui AU - Huang H AD - Health Sciences Institute, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning, China. AD - Liaoning Key Laboratory of Obesity and Glycolipid Metabolic Diseases, Puhe Rd.77, Shenyang, 110122, Liaoning, China. FAU - Sun, Chi AU - Sun C AD - Experiment Center of Science, China Medical University, Puhe Rd.77, Shenyang, 110122, Liaoning, China. FAU - Jia, Wenhan AU - Jia W AD - Health Sciences Institute, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning, China. AD - Liaoning Key Laboratory of Obesity and Glycolipid Metabolic Diseases, Puhe Rd.77, Shenyang, 110122, Liaoning, China. FAU - Zhuang, Xuxiu AU - Zhuang X AD - Health Sciences Institute, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning, China. AD - Liaoning Key Laboratory of Obesity and Glycolipid Metabolic Diseases, Puhe Rd.77, Shenyang, 110122, Liaoning, China. FAU - Zheng, Jia AU - Zheng J AD - Health Sciences Institute, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning, China. AD - Liaoning Key Laboratory of Obesity and Glycolipid Metabolic Diseases, Puhe Rd.77, Shenyang, 110122, Liaoning, China. FAU - Jiang, Le AU - Jiang L AD - Health Sciences Institute, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning, China. AD - Liaoning Key Laboratory of Obesity and Glycolipid Metabolic Diseases, Puhe Rd.77, Shenyang, 110122, Liaoning, China. FAU - Ma, Yanan AU - Ma Y AD - Liaoning Key Laboratory of Obesity and Glycolipid Metabolic Diseases, Puhe Rd.77, Shenyang, 110122, Liaoning, China. AD - School of Public Health, China Medical University, Puhe Rd.77, Shenyang, 110122, Liaoning, China. FAU - Song, Bing AU - Song B AD - First Affiliated Hospital of Jinzhou Medical University, 2-5 Renmin Road, Jinzhou, 121001, China. FAU - Gittelsohn, Joel AU - Gittelsohn J AD - Department of International Health, Human Nutrition Center, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe St Baltimore, Baltimore, MD, 21205-2179, USA. FAU - Wen, Deliang AU - Wen D AD - Health Sciences Institute, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning, China. dlwen@cmu.edu.cn. AD - Liaoning Key Laboratory of Obesity and Glycolipid Metabolic Diseases, Puhe Rd.77, Shenyang, 110122, Liaoning, China. dlwen@cmu.edu.cn. LA - eng GR - 72174208/National Natural Science Foundation of China/ GR - D21008/the 111 project/ PT - Journal Article DEP - 20260222 PL - England TA - Nutr Metab (Lond) JT - Nutrition & metabolism JID - 101231644 PMC - PMC13032390 OTO - NOTNLM OT - Biomarkers OT - Fruit and vegetable intake OT - Metabolic dysfunction OT - Obesity OT - Skin carotenoids COIS- Declarations. Ethics approval and consent to participate: Signed informed consent was obtained from the participating children and their parents or legal guardians.The study was approved by Ethics Committee of China Medical University (Approval No: Ethics Review [2021] 124). Competing interests: The authors declare no competing interests. EDAT- 2026/02/23 01:34 MHDA- 2026/02/23 01:35 PMCR- 2026/02/22 CRDT- 2026/02/22 23:23 PHST- 2025/06/11 00:00 [received] PHST- 2026/01/05 00:00 [accepted] PHST- 2026/02/23 01:35 [medline] PHST- 2026/02/23 01:34 [pubmed] PHST- 2026/02/22 23:23 [entrez] PHST- 2026/02/22 00:00 [pmc-release] AID - 10.1186/s12986-026-01075-7 [pii] AID - 1075 [pii] AID - 10.1186/s12986-026-01075-7 [doi] PST - epublish SO - Nutr Metab (Lond). 2026 Feb 22;23(1):41. doi: 10.1186/s12986-026-01075-7. PMID- 41721453 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Feb 20 TI - The relationship between problematic digital media use and food addiction, eating behaviours, and obesity: a cross-sectional study on Turkish university students. LID - 10.1186/s40359-026-04168-3 [doi] LID - 420 AB - BACKGROUND: Problematic use of social media and smartphones has been increasingly linked to unhealthy lifestyle behaviors and weight-related problems. However, limited evidence exists on how these digital behaviors are associated with food addiction and obesity in young adults. AIMS: The aim of this study is to investigate the relationship between problematic digital media use and food addiction, eating behaviours, and obesity among Turkish university students. METHOD: A cross-sectional study was conducted between December 2024 and March 2025 with 331 students. Participants completed validated instruments, including the Social Media Addiction Scale-Adult Form, the Smartphone Addiction Scale-Short Form, the Modified Yale Food Addiction Scale 2.0, and the Eating Disorder Examination Questionnaire-Short Form (EDE-Q13). Anthropometric measurements were used to calculate body mass index (BMI). RESULTS: The mean age of the participants was 20.49 +/- 3.88 years, and 81% were female. Problematic smartphone use was significantly higher among students with moderate food addiction compared to those without food addiction (p < 0.001). Severe food addic-tion was associated with higher prevalence of eating disorders (p < 0.001) and higher BMI values (p < 0.001). Weak but significant correlations were found between problematic so-cial media use and binge eating (r = 0.133, p = 0.015) as well as purging behaviors (r = 0.190, p = 0.001). Similar associations emerged between problematic smartphone use and binge eating (r = 0.136, p = 0.013). CONCLUSIONS: Findings indicate that problematic social media and smartphone use are associated with food addiction, eating disorders, and higher BMI among young adults. Nevertheless, these results highlight the need for preventive strategies addressing digital media use in the context of eating behaviors and obesity risk. CI - (c) 2026. The Author(s). FAU - Toguc, Hakan AU - Toguc H AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Inonu University, Malatya, Turkey. hakan.toguc@inonu.edu.tr. LA - eng PT - Journal Article DEP - 20260220 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Turkey/epidemiology MH - *Food Addiction/epidemiology MH - *Obesity/epidemiology MH - Male MH - Young Adult MH - Universities MH - *Students/statistics & numerical data/psychology MH - *Social Media/statistics & numerical data MH - *Feeding Behavior/psychology MH - *Internet Addiction Disorder/epidemiology MH - Adult MH - *Smartphone/statistics & numerical data MH - Digital Media MH - Adolescent MH - Body Mass Index MH - Media Exposure MH - Behavior, Addictive PMC - PMC13032488 OTO - NOTNLM OT - Eating disorders OT - Food addiction OT - Obesity OT - Problematic smartphone use OT - Problematic social media use COIS- Declarations. Ethics approval and consent to participate: The study received ethical approval from Inonu University Health Sciences Non-Interventional Ethics Committee in accordance with the Declaration of Helsinki (Ref. No. 2024/6586). The informed consent form was read to the participants and they were included in the study after their consent was obtained. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/21 00:39 MHDA- 2026/03/28 06:39 PMCR- 2026/02/20 CRDT- 2026/02/20 23:59 PHST- 2025/09/03 00:00 [received] PHST- 2026/02/09 00:00 [accepted] PHST- 2026/03/28 06:39 [medline] PHST- 2026/02/21 00:39 [pubmed] PHST- 2026/02/20 23:59 [entrez] PHST- 2026/02/20 00:00 [pmc-release] AID - 10.1186/s40359-026-04168-3 [pii] AID - 4168 [pii] AID - 10.1186/s40359-026-04168-3 [doi] PST - epublish SO - BMC Psychol. 2026 Feb 20;14(1):420. doi: 10.1186/s40359-026-04168-3. PMID- 41721323 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Feb 21 TI - Development and validation of a nomogram for assessing the risk of periodontitis in youth: a cross-sectional study. LID - 10.1186/s12903-026-07889-4 [doi] LID - 538 AB - BACKGROUND: Periodontitis is becoming increasingly common in youth. However, a validated model for assessing the risk of periodontitis in youth is lacking. This study aimed to identify independent risk factors and develop a nomogram for assessing periodontitis risk in youth within a clinical setting. METHODS: In this cross-sectional study, we recruited 807 participants aged 10-24 from the Periodontology Department of Qingdao Stomatological Hospital (Qingdao, Shandong, China). Data on 16 potential risk factors were collected. The participants were randomly allocated to the training and validation cohorts in a 7:3 ratio. Independent factors were identified via univariate and multivariate logistic regression analysis, which were then used to develop a nomogram for assessing the risk of periodontitis in youth within this clinical setting. The model's validation and performance were rigorously evaluated using the area under the curve (AUC), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), calibration plots, and decision curve analysis (DCA). RESULTS: Multivariate logistic regression analysis identified age, mouth breathing, impacted teeth, family history, and higher body mass index (BMI) as significant risk factors of periodontitis, while flossing was a protective factor. Accordingly, a nomogram was developed based on these factors as a risk assessing tool for youth in a clinical setting. Both the training and validation cohorts confirmed the nomogram's strong assessment performance, evidenced by AUC of 0.837 and 0.783, respectively. The model also maintained high sensitivity (91.2% and 86.5%) and NPV (91.5% and 90.8%) across both cohorts. Good calibration was achieved, with Brier scores of 0.162 (95% CI: 0.145-0.179) for the training cohort and 0.177 (95% CI: 0.148-0.207) for the validation cohort. Furthermore, the model's clinical utility was underscored by the DCA. CONCLUSIONS: We successfully developed and validated the nomogram for assessing the risk of periodontitis in youth within a clinical setting. With its high AUC, this model shows significant potential to support clinical decision-making by identifying high-risk individuals, thereby facilitating targeted evaluation and optimized management in specialist practice. FAU - Zhang, Ping AU - Zhang P AD - Department of Periodontology, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, Shandong, China. FAU - Sun, Degang AU - Sun D AD - Department of Cariology and Endodontology, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, Shandong, China. FAU - Wu, Han AU - Wu H AD - Department of Dean's Office, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, Shandong, China. FAU - Wang, Hongyu AU - Wang H AD - Department of Periodontology, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, Shandong, China. FAU - Pan, Jie AU - Pan J AD - Department of Periodontology, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, Shandong, China. FAU - Wu, Yingtao AU - Wu Y AD - Department of Periodontology, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, Shandong, China. 347107303@qq.com. LA - eng GR - 2023-WJZD153/Medical and Health Scientific Research Project of Qingdao/ GR - 2023-WJZD150/Medical and Health Scientific Research Project of Qingdao/ GR - 2025-2027/Qingdao Key Medical and Health Discipline Project/ GR - 2025-2027/Shandong Provincial Key Medical and Health Discipline of Oral Medicine (Qingdao University Affiliated Qingdao Stomatological Hospital)/ PT - Journal Article PT - Validation Study DEP - 20260221 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - *Nomograms MH - Cross-Sectional Studies MH - Adolescent MH - Female MH - Risk Factors MH - *Periodontitis/epidemiology/etiology MH - Child MH - Male MH - Young Adult MH - Risk Assessment/methods MH - China/epidemiology PMC - PMC13032324 OTO - NOTNLM OT - Nomogram OT - Periodontitis OT - Risk factors OT - Youth COIS- Declarations. Ethics approval and consent to participate: The study was conducted in compliance with the principles of the Declaration of Helsinki. Ethical approval was granted by the Ethics Committee at Qingdao Stomatological Hospital Affiliated to Qingdao University (2024KQYX025). Written informed consent was obtained from all participants. For participants who were under the age of 16, consent was provided by their parent or legal guardian. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/21 00:39 MHDA- 2026/06/27 06:44 PMCR- 2026/02/21 CRDT- 2026/02/20 23:50 PHST- 2025/10/03 00:00 [received] PHST- 2026/02/05 00:00 [accepted] PHST- 2026/06/27 06:44 [medline] PHST- 2026/02/21 00:39 [pubmed] PHST- 2026/02/20 23:50 [entrez] PHST- 2026/02/21 00:00 [pmc-release] AID - 10.1186/s12903-026-07889-4 [pii] AID - 7889 [pii] AID - 10.1186/s12903-026-07889-4 [doi] PST - epublish SO - BMC Oral Health. 2026 Feb 21;26(1):538. doi: 10.1186/s12903-026-07889-4. PMID- 41720915 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20261025 IS - 1476-5497 (Electronic) IS - 0307-0565 (Print) IS - 0307-0565 (Linking) VI - 50 IP - 4 DP - 2026 Apr TI - Genetic determinants of BMI, diet, and fitness interact to partially explain anthropometric obesity traits but not the metabolic consequences of obesity in men and women. PG - 938-946 LID - 10.1038/s41366-026-02027-0 [doi] AB - BACKGROUND: Understanding how genetic factors interact with diet and lifestyle to influence obesity is critical as we move towards models of precision nutrition and medicine. OBJECTIVES: To assess how genetic and lifestyle factors influence the variation in body composition and metabolic syndrome (Metsyn) risk factors. METHODS: A cross-sectional sample of age/sex/BMI-balanced 18-66 year old men and women (n = 211) from the USDA Nutritional Phenotyping Study were included in the analysis (NCT02367287). BMI polygenic risk scores (PRS) were calculated with the pgs_calc pipeline. Associations with body composition and Metsyn traits were assessed by linear regression and ANCOVA. Explained variance was evaluated using sum of squares and partial R(2), with model constraint using Bayesian information criteria. RESULTS: The PRS independently explained 15.6% of BMI variance and, after adjusting for age, sex, and genetic population structure, accounted for 11.3% of BMI variance (p(ANCOVA) = 1.1 x 10(-)(7)). Measures of diet quality, fitness, and resting metabolic rate (RMR) showed mixed independent associations with obesity traits. In best fit models, while the PRS was significant for DXA outcomes, waist circumference, and fasting TG, the explained variance was below 3% except in android-to-gynoid ratio (3.3%), lean mass index (6.6%), and waist circumference (10.1%). The BMI PRS showed subtle associations with the metabolic/physiological consequences of obesity, only waist circumference and plasma glucose were associated with PRS. Blood pressure, triglycerides, and HDL levels were not associated with PRS for obesity. CONCLUSIONS: The genetic factors influencing BMI appear to differ from those contributing to measures of adiposity and metabolic consequences of obesity. Genetic risk of high BMI was validated in this cohort, but sex, RMR, and fitness are the more refined determinants of adiposity and dysregulated metabolism in this healthy population. Future research should be sure to utilize genetic risk predictors specifically associated with maladaptive obesity traits rather than more broad associated phenotypes. CLINICAL TRIAL REGISTRY: NCT02367287. CI - (c) 2026. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply. FAU - Arrington, Carmen E AU - Arrington CE AUID- ORCID: 0000-0001-7403-5976 AD - Department of Nutrition, University of California-Davis, Davis, CA, USA. FAU - Tacad, Debra K M AU - Tacad DKM AUID- ORCID: 0000-0002-7383-1564 AD - West Coast Metabolomics Center, University of California-Davis, Davis, CA, USA. FAU - Allayee, Hooman AU - Allayee H AD - Department of Medicine, David Geffen School of Medicine of UCLA, Los Angeles, CA, USA. FAU - Sutton, Kristen J AU - Sutton KJ AUID- ORCID: 0000-0002-3704-3560 AD - Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. FAU - Dombroski, Catherine AU - Dombroski C AD - Department of Neurobiology, Physiology and Behavior, University of California-Davis, Davis, CA, USA. AD - School of Veterinary Medicine, University of California-Davis, Davis, CA, USA. FAU - Keim, Nancy L AU - Keim NL AD - Department of Nutrition, University of California-Davis, Davis, CA, USA. AD - USDA-ARS Western Human Nutrition Research Center, Davis, CA, USA. FAU - Newman, John W AU - Newman JW AUID- ORCID: 0000-0001-9632-6571 AD - West Coast Metabolomics Center, University of California-Davis, Davis, CA, USA. AD - USDA-ARS Western Human Nutrition Research Center, Davis, CA, USA. FAU - Bennett, Brian J AU - Bennett BJ AUID- ORCID: 0000-0002-0766-3195 AD - Department of Nutrition, University of California-Davis, Davis, CA, USA. brian.bennett@usda.gov. AD - USDA-ARS Western Human Nutrition Research Center, Davis, CA, USA. brian.bennett@usda.gov. LA - eng SI - ClinicalTrials.gov/NCT02367287 SI - ClinicalTrials.gov/NCT02367287 GR - T32 DK007658/DK/NIDDK NIH HHS/United States GR - 2032-10700-003-000-D/USDA project/ GR - 2032-51530-025-00D/USDA project/ PT - Journal Article DEP - 20260220 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 SB - IM MH - Humans MH - *Body Mass Index MH - Male MH - *Obesity/genetics/epidemiology/physiopathology/metabolism MH - Female MH - Adult MH - Middle Aged MH - Cross-Sectional Studies MH - Adolescent MH - Metabolic Syndrome/genetics/epidemiology MH - *Diet/statistics & numerical data MH - Aged MH - *Physical Fitness/physiology MH - Body Composition/genetics MH - Young Adult MH - Genetic Risk Score MH - Genetic Predisposition to Disease PMC - PMC13056523 COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/02/21 00:40 MHDA- 2026/04/08 00:30 PMCR- 2026/02/20 CRDT- 2026/02/20 23:25 PHST- 2025/06/24 00:00 [received] PHST- 2026/01/27 00:00 [accepted] PHST- 2025/12/15 00:00 [revised] PHST- 2026/04/08 00:30 [medline] PHST- 2026/02/21 00:40 [pubmed] PHST- 2026/02/20 23:25 [entrez] PHST- 2026/02/20 00:00 [pmc-release] AID - 10.1038/s41366-026-02027-0 [pii] AID - 2027 [pii] AID - 10.1038/s41366-026-02027-0 [doi] PST - ppublish SO - Int J Obes (Lond). 2026 Apr;50(4):938-946. doi: 10.1038/s41366-026-02027-0. Epub 2026 Feb 20. PMID- 41719248 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 2 DP - 2026 TI - Psychological and lifestyle correlates of eating behavior and adiposity: Structural and latent profile modeling. PG - e0343336 LID - 10.1371/journal.pone.0343336 [doi] LID - e0343336 AB - BACKGROUND: Psychological vulnerabilities, including early maladaptive schemas (EMS) and difficulties in emotion regulation, are associated with dysregulated eating and adiposity. However, evidence integrating these mechanisms with contextual and lifestyle factors within a single framework remains limited. This study examined an integrative model of psychological and lifestyle correlates of eating behavior and adiposity in a large adult sample. METHODS: A community sample of 1,500 adults (53% women; aged 18-65 years) completed validated measures of EMS, difficulties in emotion regulation, perceived stress, social support, eating behaviors, diet quality, and physical activity. Body mass index and waist circumference were assessed using standardized procedures. Structural equation modeling tested direct, indirect, and conditional associations, with multi-group analyses examining gender and age differences. Latent profile analysis identified subgroups with distinct psychological and lifestyle constellations. RESULTS: Higher EMS were associated with greater difficulties in emotion regulation. Emotion regulation difficulties were positively associated with emotional and habitual overeating (stronger among women) and showed a modest negative association with dietary restraint. Indirect effects of EMS via emotion regulation were small and limited to dietary restraint. Perceived stress did not moderate the EMS-emotion regulation association, whereas perceived social support showed a small buffering effect. Eating behaviors were associated with poorer diet quality related to higher body mass index and waist circumference, while physical activity and sedentary behavior showed independent associations with adiposity. Latent profile analysis supported a two-profile solution (higher- vs. lower-risk), characterized by distinct psychological, behavioral, and adiposity patterns. CONCLUSIONS: Cognitive-emotional vulnerabilities are associated with eating dysregulation and adiposity, but emotion regulation plays a selective and modest mediating role limited to dietary restraint. Lifestyle behaviors contribute independently to adiposity alongside psychological pathways, supporting integrative, multidimensional models. Given the cross-sectional design, all findings are correlational and do not imply causality. CI - Copyright: (c) 2026 Malgorzata Obara-Golebiowska. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Obara-Golebiowska, Malgorzata AU - Obara-Golebiowska M AUID- ORCID: 0000-0003-0057-4365 AD - Department of Clinical, Developmental and Educational Psychology, Faculty of Social Sciences, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland. LA - eng PT - Journal Article DEP - 20260220 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - *Adiposity MH - *Feeding Behavior/psychology MH - *Life Style MH - Middle Aged MH - Male MH - Adult MH - Adolescent MH - Body Mass Index MH - Aged MH - Young Adult MH - Emotional Regulation MH - Waist Circumference MH - Social Support MH - Stress, Psychological MH - Emotional Eating PMC - PMC12922993 COIS- I have read the journal's policy and the author of this manuscript has declared that no competing interests exist. EDAT- 2026/02/20 21:28 MHDA- 2026/02/20 21:29 PMCR- 2026/02/20 CRDT- 2026/02/20 13:33 PHST- 2025/10/13 00:00 [received] PHST- 2026/02/04 00:00 [accepted] PHST- 2026/02/20 21:29 [medline] PHST- 2026/02/20 21:28 [pubmed] PHST- 2026/02/20 13:33 [entrez] PHST- 2026/02/20 00:00 [pmc-release] AID - PONE-D-25-55256 [pii] AID - 10.1371/journal.pone.0343336 [doi] PST - epublish SO - PLoS One. 2026 Feb 20;21(2):e0343336. doi: 10.1371/journal.pone.0343336. eCollection 2026. PMID- 41718139 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 2076-3271 (Electronic) IS - 2076-3271 (Linking) VI - 14 IP - 1 DP - 2026 Feb 15 TI - Early Childhood Anxiety and Maternal Factors: Associations with State and Trait Anxiety in a Greek Cohort of Preschoolers. LID - 10.3390/medsci14010092 [doi] LID - 92 AB - BACKGROUND/OBJECTIVE: Anxiety symptoms in preschool children represent early indicators of potential mental health vulnerabilities. Maternal psychological, sociodemographic, lifestyle and dietary factors may be associated with child emotional development; however, evidence regarding their independent contributions to distinct dimensions of child anxiety (trait vs. state) remains limited. This study aimed to examine maternal factors associated with preschool children's trait and state anxiety. METHODS: In this cross-sectional study conducted in Greece, 200 preschool-aged children and their mothers were assessed. Maternal demographic, socioeconomic, anthropometric, lifestyle, dietary, and psychosocial characteristics were evaluated using validated instruments, including the Mediterranean Diet Score (MedDietScore), Beck Depression Inventory-II (BDI-II), and the State-Trait Anxiety Inventory short form (STAI-6). Children's trait and state anxiety were assessed using the State-Trait Anxiety Inventory for Children (STAI-CH). Bivariate analyses were conducted, followed by separate multivariable linear regression models for trait and state anxiety, with covariate selection guided by a directed acyclic graph (DAG). RESULTS: Maternal anxiety was positively associated with children's state anxiety (B = 1.508, SE = 0.566, beta = 0.196, t = 2.666, p = 0.008; 95% CI [0.43, 2.66]). Higher maternal educational attainment demonstrated a weak positive association with child state anxiety (B = 1.061, SE = 0.509, beta = 0.145, t = 2.086, p = 0.038; 95% CI [0.08, 2.09]), which may reflect greater awareness or reporting of child symptoms by more-educated mothers or other unmeasured factors. For trait anxiety, maternal depressive symptomatology exhibited the strongest association (B = 3.578, SE = 0.918, beta = 0.276, t = 3.897, p < 0.001; 95% CI [1.77, 5.39]), while maternal anxiety was also independently associated with higher trait anxiety (B = 2.088, SE = 0.744, beta = 0.194, t = 2.807, p = 0.006; 95% CI [0.62, 3.56]). The models explained a modest proportion of variance (R(2) < 0.15), indicating that most variation in child anxiety does not seem to be fully explained by the specific measured maternal factors. CONCLUSIONS: Maternal psychological distress was modestly associated with preschool children's state and trait anxiety, exhibiting differential patterns across anxiety dimensions. These findings should be interpreted as correlational, with unmeasured contributors such as paternal mental health, family functioning, genetics, and school/peer influences likely playing important roles. Early screening and interventions addressing maternal mental health may support children's emotional well-being, but further multi-informant and longitudinal research is needed to clarify temporal and causal pathways. FAU - Angelakou, Exakousti-Petroula AU - Angelakou EP AUID- ORCID: 0009-0005-3783-1654 AD - Department of Food Science and Nutrition, School of Environment, University of Aegean, 81400 Lemnos, Greece. FAU - Papadopoulou, Sousana K AU - Papadopoulou SK AUID- ORCID: 0000-0002-6408-6128 AD - Department of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, 57400 Thessaloniki, Greece. FAU - Pavlidou, Eleni AU - Pavlidou E AUID- ORCID: 0000-0002-7764-3544 AD - Department of Food Science and Nutrition, School of Environment, University of Aegean, 81400 Lemnos, Greece. AD - Department of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, 57400 Thessaloniki, Greece. FAU - Louka, Aikaterini AU - Louka A AD - Department of Food Science and Nutrition, School of Environment, University of Aegean, 81400 Lemnos, Greece. FAU - Gerothanasi, Konstantina AU - Gerothanasi K AD - Department of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, 57400 Thessaloniki, Greece. FAU - Giaginis, Constantinos AU - Giaginis C AUID- ORCID: 0000-0003-2878-4831 AD - Department of Food Science and Nutrition, School of Environment, University of Aegean, 81400 Lemnos, Greece. LA - eng PT - Journal Article DEP - 20260215 PL - Switzerland TA - Med Sci (Basel) JT - Medical sciences (Basel, Switzerland) JID - 101629322 SB - IM MH - Humans MH - Greece/epidemiology MH - Female MH - *Anxiety/psychology/epidemiology MH - Child, Preschool MH - *Mothers/psychology MH - Cross-Sectional Studies MH - Male PMC - PMC12922043 OTO - NOTNLM OT - child anxiety OT - early childhood mental health OT - maternal factors OT - preschool children OT - state anxiety OT - trait anxiety COIS- The authors declare no conflicts of interest. EDAT- 2026/02/20 16:08 MHDA- 2026/02/20 16:09 PMCR- 2026/02/15 CRDT- 2026/02/20 08:23 PHST- 2026/01/13 00:00 [received] PHST- 2026/02/12 00:00 [revised] PHST- 2026/02/13 00:00 [accepted] PHST- 2026/02/20 16:09 [medline] PHST- 2026/02/20 16:08 [pubmed] PHST- 2026/02/20 08:23 [entrez] PHST- 2026/02/15 00:00 [pmc-release] AID - medsci14010092 [pii] AID - medsci-14-00092 [pii] AID - 10.3390/medsci14010092 [doi] PST - epublish SO - Med Sci (Basel). 2026 Feb 15;14(1):92. doi: 10.3390/medsci14010092. PMID- 41717623 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Preliminary effects and feasibility of a school-based regular aerobic exercise intervention on PTSD-related symptoms among college students: a single-group pre-post study. PG - 1742648 LID - 10.3389/fpubh.2026.1742648 [doi] LID - 1742648 AB - BACKGROUND: College students are considered a high-risk group for post-traumatic stress disorder (PTSD). Existing non-pharmacological interventions, although effective and accessible, still have notable limitations. Regular aerobic exercise, as a potential mental health promotion strategy, requires empirical validation in real campus environments to determine its specific effects on reducing anxiety, depression, and PTSD symptoms, as well as its role in enhancing psychological resilience. METHOD: This study employed a single-group pre-test/post-test design and was conducted in August 2025 at a comprehensive university in Sichuan, China. Using convenience sampling, 47 participants with elevated PTSD symptoms were recruited for the "School-Based Regular Aerobic Exercise" intervention trial (operationalized as a 21-Day Exercise Check-In Activity). All participants engaged in 30 min of aerobic exercise daily for 3 weeks. Before and after the intervention, participants completed the PTSD Checklist for DSM-5 (PCL-5), Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), and Connor-Davidson Resilience Scale (CD-RISC). RESULT: All 47 participants completed the 21-day intervention. Significant pre- to post-intervention improvements were observed in PTSD symptoms, anxiety, depression, and psychological resilience. Clinical significance analysis showed that 57.45% of participants fell below the PTSD clinical cutoff after the intervention, and 87.23% demonstrated reliable change. Exploratory change-score analyses indicated that improvements in resilience were significantly associated with reductions in anxiety and PTSD symptoms, but not depression. CONCLUSION: In a real-world campus setting, this 21-day school-based regular aerobic exercise intervention appears feasible and is associated with improvements in PTSD-related symptoms and psychological resilience. However, because the study lacked randomization and a control group, causal inferences regarding effectiveness and underlying mechanisms cannot be made. Randomized controlled trials with longer follow-up periods and objective activity measures are warranted. CI - Copyright (c) 2026 Jing, Yang, Ren, Ke, Deng, Zhang, Hui, Yao, Xie, Liu and Mohamad Alwi. FAU - Jing, Yuanyuan AU - Jing Y AD - School of Management, North Sichuan Medical College, Nanchong, Sichuan, China. AD - Key Laboratory of Digital-Intelligent Disease Surveillance and Health Governance, North Sichuan Medical College, Nanchong, China. AD - School of Graduate Studies, Post Graduate Centre, Management and Science University, Shah Alam, Selangor, Malaysia. FAU - Yang, Dajun AU - Yang D AD - School of Management, North Sichuan Medical College, Nanchong, Sichuan, China. FAU - Ren, Yun AU - Ren Y AD - School of Laboratory Medicine, North Sichuan Medical College, Nanchong, Sichuan, China. FAU - Ke, Xiong AU - Ke X AD - School of Management, North Sichuan Medical College, Nanchong, Sichuan, China. AD - Key Laboratory of Digital-Intelligent Disease Surveillance and Health Governance, North Sichuan Medical College, Nanchong, China. FAU - Deng, Yuanyuan AU - Deng Y AD - School of Management, North Sichuan Medical College, Nanchong, Sichuan, China. FAU - Zhang, Juan AU - Zhang J AD - School of Management, North Sichuan Medical College, Nanchong, Sichuan, China. FAU - Hui, Honggang AU - Hui H AD - School of Management, North Sichuan Medical College, Nanchong, Sichuan, China. FAU - Yao, Yu AU - Yao Y AD - School of Management, North Sichuan Medical College, Nanchong, Sichuan, China. FAU - Xie, Xinling AU - Xie X AD - School of Clinical Medicine, North Sichuan Medical College, Nanchong, Sichuan, China. FAU - Liu, Ruining AU - Liu R AD - School of Clinical Medicine, North Sichuan Medical College, Nanchong, Sichuan, China. FAU - Mohamad Alwi, Muhammad Najib AU - Mohamad Alwi MN AD - Department of Psychiatry, International Medical School, Management and Science University, Shah Alam, Malaysia. LA - eng PT - Journal Article DEP - 20260204 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Stress Disorders, Post-Traumatic/therapy/psychology MH - *Students/psychology/statistics & numerical data MH - Female MH - *Exercise/psychology MH - Universities MH - Feasibility Studies MH - China MH - Male MH - Young Adult MH - Depression MH - Anxiety MH - Adolescent PMC - PMC12913432 OTO - NOTNLM OT - anxiety OT - depression OT - post-traumatic stress disorder OT - psychological resilience OT - school-based regular aerobic exercise intervention COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/20 07:05 MHDA- 2026/02/20 07:06 PMCR- 2026/02/04 CRDT- 2026/02/20 05:00 PHST- 2025/11/09 00:00 [received] PHST- 2026/01/08 00:00 [revised] PHST- 2026/01/14 00:00 [accepted] PHST- 2026/02/20 07:06 [medline] PHST- 2026/02/20 07:05 [pubmed] PHST- 2026/02/20 05:00 [entrez] PHST- 2026/02/04 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1742648 [doi] PST - epublish SO - Front Public Health. 2026 Feb 4;14:1742648. doi: 10.3389/fpubh.2026.1742648. eCollection 2026. PMID- 41717043 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260220 LR - 20260920 IS - 2976-9337 (Electronic) IS - 2976-9337 (Linking) VI - 3 IP - 1 DP - 2026 Jan TI - Cross-cohort federated learning for pediatric abdominal adipose tissue segmentation and quantification using free-breathing 3D MRI. PG - umag002 LID - 10.1093/radadv/umag002 [doi] LID - umag002 AB - BACKGROUND: Pediatric abdominal visceral and subcutaneous adipose tissue (VAT, SAT) quantified on magnetic resonance imaging (MRI) can assess risk for metabolic diseases. However, the complex structure of VAT in children and the lack of sufficient MRI datasets pose challenges for developing automated segmentation methods. PURPOSE: To achieve accurate and rapid automated segmentation of pediatric abdominal VAT and SAT on motion-robust free-breathing (FB) 3D Dixon MRI by developing a cross-cohort federated learning (FL) framework that leverages adult datasets. MATERIALS AND METHODS: 3D FB-MRI datasets were prospectively acquired in children 6-18 years old (single center, 2 scanners; 2016-2023) and used to train 3D neural network models for segmenting abdominal VAT and SAT. The FL model was trained across the pediatric cohort and a separate adult cohort (5 centers, 7 scanners) without requiring direct data sharing. Segmentation performance of the FL model was assessed by Dice scores with respect to references and compared with standalone local training and joint training with full data access. Quantification of VAT and SAT volume and proton-density fat fraction (PDFF) was compared against references using intraclass correlation coefficients (ICCs) and Bland-Altman analysis. Differences between training approaches were analyzed using the Kruskal-Wallis test followed by paired Wilcoxon signed-rank tests. RESULTS: The FL model, trained and tested with 134 children (mean age, 13.3 years +/- 2.7 [standard deviation]; 71 males) and 920 adults (50.4 years +/- 14.0; 677 females), achieved mean Dice scores of 91.09% (VAT) and 95.55% (SAT), outperforming standalone training (VAT: P < .001) and performing comparably to joint training (VAT: P = .21). Volume quantification demonstrated strong agreement (VAT: ICC = 0.99, SAT: ICC = 1.00). PDFF quantification showed small mean differences (VAT: 0.21%, SAT: -1.19%). Inference time was <3 seconds for each subject. CONCLUSION: The proposed FL framework achieved accurate and rapid automated segmentation and quantification of pediatric abdominal VAT and SAT on 3D FB-MRI. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Radiological Society of North America. FAU - Zhang, Wenwen AU - Zhang W AUID- ORCID: 0000-0002-5362-5405 AD - Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, United States. AD - Physics and Biology in Medicine Interdepartmental Program, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, United States. FAU - Kafali, Sevgi Gokce AU - Kafali SG AD - Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, United States. AD - Chair for Artificial Intelligence in Healthcare and Medicine, School of Computation, Information and Technology, Technical University of Munich, Munich, 80333, Germany. FAU - Adamos, Timothy AU - Adamos T AD - Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, United States. FAU - Kuwahara, Kelsey AU - Kuwahara K AD - Department of Cognitive Science, University of California Los Angeles, Los Angeles, CA, 90095, United States. FAU - Dong, Ashley AU - Dong A AD - Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, United States. FAU - Li, Jessica AU - Li J AD - Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, United States. FAU - Shih, Shu-Fu AU - Shih SF AD - Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, United States. FAU - Delgado-Esbenshade, Timoteo AU - Delgado-Esbenshade T AD - Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, United States. AD - Physics and Biology in Medicine Interdepartmental Program, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, United States. FAU - Chowdhury, Shilpy AU - Chowdhury S AD - Department of Radiology, Loma Linda University School of Behavioral Health, Loma Linda, CA, 92350, United States. FAU - Loong, Spencer AU - Loong S AD - Department of Psychology, Loma Linda University School of Behavioral Health, Loma Linda, CA, 92350, United States. FAU - Moretz, Jeremy AU - Moretz J AD - Department of Neuroradiology, Loma Linda University School of Behavioral Health, Loma Linda, CA, 92350, United States. FAU - Barnes, Samuel R AU - Barnes SR AD - Department of Radiology, Loma Linda University School of Behavioral Health, Loma Linda, CA, 92350, United States. FAU - Li, Zhaoping AU - Li Z AUID- ORCID: 0000-0002-8662-4310 AD - Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, United States. FAU - Ghahremani, Shahnaz AU - Ghahremani S AD - Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, United States. FAU - Calkins, Kara L AU - Calkins KL AD - Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, United States. FAU - Wu, Holden H AU - Wu HH AUID- ORCID: 0000-0002-2585-5916 AD - Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, United States. AD - Physics and Biology in Medicine Interdepartmental Program, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, United States. LA - eng GR - R01 DK124417/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20260119 PL - England TA - Radiol Adv JT - Radiology advances JID - 9918840888906676 PMC - PMC12916172 OTO - NOTNLM OT - adipose tissue OT - federated learning OT - magnetic resonance imaging OT - pediatric obesity OT - segmentation COIS- Please see ICMJE form(s) for author conflicts of interest. These have been provided as supplementary materials. None declared. EDAT- 2026/02/20 07:05 MHDA- 2026/02/20 07:06 PMCR- 2026/01/19 CRDT- 2026/02/20 04:54 PHST- 2025/10/24 00:00 [received] PHST- 2025/12/23 00:00 [revised] PHST- 2026/01/09 00:00 [accepted] PHST- 2026/02/20 07:06 [medline] PHST- 2026/02/20 07:05 [pubmed] PHST- 2026/02/20 04:54 [entrez] PHST- 2026/01/19 00:00 [pmc-release] AID - umag002 [pii] AID - 10.1093/radadv/umag002 [doi] PST - epublish SO - Radiol Adv. 2026 Jan 19;3(1):umag002. doi: 10.1093/radadv/umag002. eCollection 2026 Jan. PMID- 41716303 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260220 LR - 20260813 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - Spanish translation and cross-cultural adaptation and validation of the social motivational orientations in sport scale for children. PG - 1743553 LID - 10.3389/fspor.2026.1743553 [doi] LID - 1743553 AB - BACKGROUND: Social motivation plays a key role in sports participation but is underexplored in measurement tools. The Social Motivational Orientations in Sport Scale (SMOSS) is the only instrument assessing these orientations; however, no Spanish version exists for children. The primary objective of this study was to culturally adapt and psychometrically validate a Spanish version of the SMOSS for children aged 6-12 years. METHODS: The SMOSS for children (SMOSS-C) was translated and culturally adapted. Comprehension was evaluated through cognitive interviews, and reliability was assessed via test-retest with 128 Spanish schoolchildren. Analyses included confirmatory factor analysis (CFA), Cronbach's alpha (alpha), and intraclass correlation coefficient (ICC). RESULTS: CFA confirmed the three-factor structure (affiliation, recognition, status) with excellent fit indices (chi (2)/df = 1.667, RMSEA =.072, CFI =.943, TLI =.926). Internal consistency ranged from questionable to good (alpha = .636-.891), except for items 6 and 15 (poor/unacceptable). Temporal stability was moderate to near-perfect (ICC =.467-.891), with items 6 and 15 showing only fair agreement. Measurement error was low for the total score (SEM% = 7.0; MDC% = 19.5), indicating good accuracy. CONCLUSIONS: The SMOSS-C shows a valid factorial structure, acceptable internal consistency, and good temporal reliability for most items and the overall score. Despite two weaker items, it is a reliable tool for assessing social motivational orientations in sport among Spanish schoolchildren. It enhances understanding of social influences on motivation for physical activity and informs pedagogical strategies. As part of the social domain, the SMOSS-C supports the Spanish Physical Literacy Assessment for Children (SPLA-C) model, the first physical literacy assessment instrument in Spain. CI - (c) 2026 Pastor-Cisneros, Mendoza-Munoz, Francisco Lopez-Gil and Carlos-Vivas. FAU - Pastor-Cisneros, Raquel AU - Pastor-Cisneros R AD - Physical Activity for Education, Performance and Health (PAEPH) Research Group, Faculty of Sport Sciences, University of Extremadura, Caceres, Spain. FAU - Mendoza-Munoz, Maria AU - Mendoza-Munoz M AD - Department of Communication and Education, Universidad Loyola Andalucia, Sevilla, Spain. FAU - Francisco Lopez-Gil, Jose AU - Francisco Lopez-Gil J AD - School of Medicine, Universidad Espiritu Santo, Samborondon, Ecuador. AD - Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno, Chile. FAU - Carlos-Vivas, Jorge AU - Carlos-Vivas J AD - Physical Activity for Education, Performance and Health (PAEPH) Research Group, Faculty of Sport Sciences, University of Extremadura, Caceres, Spain. LA - eng PT - Journal Article DEP - 20260204 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC12914941 OTO - NOTNLM OT - Assessment OT - SPLA-C OT - exercise OT - physical activity OT - physical literacy OT - school children COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/20 07:05 MHDA- 2026/02/20 07:06 PMCR- 2026/02/04 CRDT- 2026/02/20 04:45 PHST- 2025/11/11 00:00 [received] PHST- 2026/01/07 00:00 [revised] PHST- 2026/01/12 00:00 [accepted] PHST- 2026/02/20 07:06 [medline] PHST- 2026/02/20 07:05 [pubmed] PHST- 2026/02/20 04:45 [entrez] PHST- 2026/02/04 00:00 [pmc-release] AID - 10.3389/fspor.2026.1743553 [doi] PST - epublish SO - Front Sports Act Living. 2026 Feb 4;8:1743553. doi: 10.3389/fspor.2026.1743553. eCollection 2026. PMID- 41712798 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20260828 IS - 2724-7031 (Electronic) IS - 0041-4131 (Linking) VI - 103 IP - 5 DP - 2025 May 5 TI - Body Esteem and Associated Factors Among Tunisian Adolescents. PG - 642-646 LID - 10.62438/tunismed.v103i5.5575 [doi] AB - Introduction-Aim: Adolescents go through morphological and psychosocial changes that greatly influence body perception and body esteem. The aim of this study was to explore and describe body esteem among Tunisian adolescents. METHODS: We conducted a cross-sectional study involving 340 adolescents who attend Tunisian high school. We collected the age, sex, weight, and height of each participant and we used Tunisian validated version of BESAA, the Arabic version of Rosenberg Self Esteem Scale and the F-SCOFF questionnaire to assess each participant's body esteem, self-esteem and eating disorders respectively. RESULTS: We included 340 adolescents with a sex-ratio 0.7, among the 340 participants, 58.2% had a normal BMI. We found that 78.6% and 79.7% of adolescents have respectively good body esteem and high self-esteem with a similar distribution between girls and boys. Body esteem was associated with a variety of factors, including age, self-esteem, the practice of regular sports activities and BMI, however, it was not associated with the F-SCOFF questionnaire. CONCLUSIONS: The increasing preoccupation of teenagers with their body image makes it essential to study body esteem in this population to detect disorders that may stem from body dissatisfaction. FAU - Rezgui, Hela AU - Rezgui H AD - Mongi Slim University Hospital, Child Psychiatry Department, University of Tunis El Manar, Faculty of Medicine of Tunis, 1007, Tunis, Tunisia. FAU - Bourgou, Soumaya AU - Bourgou S AD - Mongi Slim University Hospital, Child psychiatry department, Laboratory of research 'Sante Mere- Bebe' LR22SP01, 2046, Tunis, Tunisia. FAU - Hamza, Meriem AU - Hamza M AD - Mongi Slim University Hospital, Child psychiatry department, Laboratory of research 'Sante Mere- Bebe' LR22SP01, 2046, Tunis, Tunisia. FAU - Fakhfakh, Radhouane AU - Fakhfakh R AD - Mongi Slim University Hospital, Child psychiatry department, Laboratory of research 'Sante Mere- Bebe' LR22SP01, 2046, Tunis, Tunisia. FAU - Belhadj, Ahlem AU - Belhadj A AD - Mongi Slim University Hospital, Child psychiatry department, Laboratory of research 'Sante Mere- Bebe' LR22SP01, 2046, Tunis, Tunisia. LA - eng PT - Journal Article DEP - 20250505 PL - Tunisia TA - Tunis Med JT - La Tunisie medicale JID - 0413766 SB - IM MH - *Self Concept MH - *Body Image/psychology MH - *Psychology, Adolescent MH - Tunisia/epidemiology MH - Cross-Sectional Studies MH - *Feeding and Eating Disorders/diagnosis/epidemiology/psychology MH - Self Report/statistics & numerical data MH - Surveys and Questionnaires/statistics & numerical data MH - Humans MH - Male MH - Female MH - Child MH - Adolescent MH - Body Mass Index OTO - NOTNLM OT - Adolescents OT - Body Esteem OT - Body Image OT - Eating Disorders OT - Self-Esteem OT - Sport Activities EDAT- 2026/02/19 19:02 MHDA- 2026/02/19 19:03 CRDT- 2026/02/19 15:42 PHST- 2024/11/12 00:00 [received] PHST- 2025/03/16 00:00 [accepted] PHST- 2026/02/19 19:03 [medline] PHST- 2026/02/19 19:02 [pubmed] PHST- 2026/02/19 15:42 [entrez] AID - /article/view/5575 [pii] AID - 10.62438/tunismed.v103i5.5575 [doi] PST - epublish SO - Tunis Med. 2025 May 5;103(5):642-646. doi: 10.62438/tunismed.v103i5.5575. PMID- 41712558 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 2 DP - 2026 TI - Protocol for the 'exploration of mental well-being, health-related quality of life, and psychosocial outcomes in youths on dialysis in New Zealand: A cross-sectional methods study'. PG - e0340006 LID - 10.1371/journal.pone.0340006 [doi] LID - e0340006 AB - INTRODUCTION: It is well accepted that young individuals on dialysis have poor clinical outcomes, although it is increasing apparent that they have similarly poor patient-centred ones. We study these latter outcomes in the population of youths undergoing dialysis in Aotearoa New Zealand (AoNZ). This study aims to report their sociodemographic and clinical characteristics, and explore their mental well-being and health-related quality of life, and how these outcomes are influenced by factors such as self-efficacy, physical activity, mood, and social anxiety. METHODS: A cross-sectional survey will be conducted of youths aged 15-24 years on dialysis in AoNZ with eligible youths on dialysis across AoNZ, using validated psychometric instruments to assess daily activities, mental health, quality of life, social interactions, and self-efficacy. Open-ended questions within the survey will collect qualitative data. Clinical and demographic data will be established from clinical records and linked public health databases. ANALYSIS: Quantitative data will be analyzed using descriptive statistics and structural equation modeling to explore associations between psychometric constructs, mental well-being, and quality of life. Open-ended questions will be analysed using qualitative content analysis. ETHICS AND DISSEMINATION: Informed consent will be sought from all participants. The research will adhere to data protection guidelines, ensuring that participants' rights and confidentiality are protected. Results will be disseminated through academic publications, conferences, and summary reports provided to participants and stakeholders. CI - Copyright: (c) 2026 Jaganathan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Jaganathan, Kavitha AU - Jaganathan K AUID- ORCID: 0000-0003-1102-0915 AD - Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. FAU - Serlachius, Anna AU - Serlachius A AD - Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. FAU - Prestidge, Chanel AU - Prestidge C AD - Department of Paediatric Nephrology, Starship Children's Health, Te Whatu Ora Health New Zealand Te Toka Tumai Auckland, Auckland, New Zealand. FAU - Doss, Fredric S AU - Doss FS AUID- ORCID: 0000-0002-1571-6138 AD - Renal Physiology, Auckland City Hospital, Te Whatu Ora Health New Zealand Te Toka Tumai Auckland, Auckland, New Zealand. AD - Department of Science, Auckland University of Technology, Auckland, New Zealand. FAU - Marshall, Mark R AU - Marshall MR AUID- ORCID: 0000-0003-0499-4527 AD - Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. AD - Department of Medicine, Waitakere Hospital, Te Whatu Ora Health New Zealand Waitemata, Auckland, New Zealand. LA - eng PT - Journal Article DEP - 20260219 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Quality of Life MH - New Zealand MH - Cross-Sectional Studies MH - Adolescent MH - *Renal Dialysis/psychology MH - Male MH - *Mental Health MH - Female MH - Young Adult MH - Psychological Well-Being MH - Self Efficacy MH - Surveys and Questionnaires MH - Psychometrics PMC - PMC12919795 COIS- The authors have declared that no competing interests exist. EDAT- 2026/02/19 19:02 MHDA- 2026/02/19 19:03 PMCR- 2026/02/19 CRDT- 2026/02/19 13:33 PHST- 2025/10/28 00:00 [received] PHST- 2025/12/15 00:00 [accepted] PHST- 2026/02/19 19:03 [medline] PHST- 2026/02/19 19:02 [pubmed] PHST- 2026/02/19 13:33 [entrez] PHST- 2026/02/19 00:00 [pmc-release] AID - PONE-D-25-52324 [pii] AID - 10.1371/journal.pone.0340006 [doi] PST - epublish SO - PLoS One. 2026 Feb 19;21(2):e0340006. doi: 10.1371/journal.pone.0340006. eCollection 2026. PMID- 41711279 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260708 IS - 0035-7715 (Print) IS - 0035-7715 (Linking) VI - 76 IP - 3 DP - 2025 Nov 19 TI - Assessing the effects of social media on eating behavior in Algerian university students. PG - 211-220 LID - 210413 [pii] LID - 10.32394/rpzh/210413 [doi] AB - BACKGROUND: Social media plays a central role in the daily lives of university students, influencing various aspects of behavior, especially their eating habits. The goal of this study was to adapt and validate the scale of effects of social media on eating behavior (SESMEB), which was initially established in Turkish, for use by Algerian university students. MATERIAL AND METHODS: A cross-sectional study was conducted between March 2025 and May 2025. Participants filled out an online questionnaire covering socio-demographic data, social media usage patterns, and the SESMEB. Internal consistency was assessed using Cronbach's alpha and the Spearman-Brown coefficient was used to measure reliability. Confirmatory Factor Analysis (CFA) was used to assess construct validity, and independent t-tests were used to investigate item discrimination across extreme groups. RESULTS: The Algerian version of SESMEB demonstrated excellent internal consistency (Cronbach's alpha = 0.930). CFA confirmed a strong unidimensional structure, with factor loadings ranging from 0.49 to 0.75 and high model fit indices. SESMEB scores were significantly correlated with daily social media time (p < 0.001), indicating that higher social media engagement corresponded to a greater influence on eating behavior. CONCLUSION: The adapted SESMEB is a valid and reliable instrument for assessing the influence of social media on eating habits among Algerian university students. These findings provide a foundation for future study focused at encouraging healthy digital and nutritional behaviors among young people. FAU - Meskini, Zakaria AU - Meskini Z AD - Department of Agricultural Sciences, Laboratory of Environment, Natural Plant Substances and Food Technology, University of Relizane, Algeria. FAU - Zouaoui, Khadidja AU - Zouaoui K AD - Department of Agricultural Sciences, University of Moulay Tahar Saida, Algeria. FAU - Seddar-Yagoub, Fatima AU - Seddar-Yagoub F AD - Department of Agricultural Sciences, Laboratory of Animal Production Sciences and Techniques, University of Abdelhamid Ibn Badis, Algeria. FAU - Bounaama, Khalil AU - Bounaama K AD - Department of Agricultural Sciences, Laboratory of Animal Production Sciences and Techniques, University of Abdelhamid Ibn Badis, Algeria. FAU - Touahri, Ahmed AU - Touahri A AD - Department of Natural and Life Sciences, Agronomy Environment Laboratory, Tissemsilt University, Algeria. LA - eng PT - Journal Article DEP - 20251106 PL - Poland TA - Rocz Panstw Zakl Hig JT - Roczniki Panstwowego Zakladu Higieny JID - 0414756 SB - IM MH - Humans MH - *Feeding Behavior/psychology MH - Female MH - *Students/psychology/statistics & numerical data MH - Male MH - Algeria MH - Young Adult MH - Cross-Sectional Studies MH - Universities MH - *Social Media/statistics & numerical data MH - Surveys and Questionnaires/standards MH - Adult MH - Reproducibility of Results MH - Adolescent MH - Media Exposure MH - Digital Media OTO - NOTNLM OT - Algerian students OT - eating behavior OT - reliability OT - social media OT - validity EDAT- 2026/02/19 17:36 MHDA- 2026/02/19 17:37 CRDT- 2026/02/19 07:24 PHST- 2026/02/19 17:37 [medline] PHST- 2026/02/19 17:36 [pubmed] PHST- 2026/02/19 07:24 [entrez] AID - 210413 [pii] AID - 10.32394/rpzh/210413 [doi] PST - ppublish SO - Rocz Panstw Zakl Hig. 2025 Nov 19;76(3):211-220. doi: 10.32394/rpzh/210413. Epub 2025 Nov 6. PMID- 41711263 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2026 Feb 19 TI - The cost of a healthy diet and its association with BMI in crisis-stricken Lebanon. PG - e42 LID - 10.1017/S1368980026102092 [doi] LID - e42 AB - OBJECTIVES: This study aimed to determine the prevalence of Lebanese adults living with underweight, overweight or obesity, assess and compare the cost of the Mediterranean Diet (MD) with that of the current dietary consumption pattern and explore diet cost as a determinant of living with underweight, overweight or obesity. DESIGN: Data for this nationally representative cross-sectional study were collected through sociodemographic questionnaires, anthropometric measurements, the Arab Family Food Security Scale and dietary assessments using a validated FFQ and 24-h recalls. Diet costs were calculated based on 2023 market prices using purchasing power parity. Logistic regression was used to assess associations with BMI. SETTING: Lebanon, using data representative of the Lebanese adults' population. PARTICIPANTS: 444 Lebanese residents aged 18-64 years. RESULTS: Overall, 66.2 % of the participants were living with underweight (4.3 %), overweight (37.8 %) or obesity (24.1 %). On average, the cost of following MD ranged from Intl.$ 23.36 to Intl.$ 26.49/person/d, whereas a Lebanese adult spent Intl.$ 20.46 on consumption. Only 31.1 % of participants spent an amount equal to or greater than the minimum MD cost (Intl. $23.36/d). Participants who meet or exceed this threshold were 1.59 times more likely to be living with a healthy weight (aOR = 1.59, p = 0.043). CONCLUSIONS: The high prevalence of Lebanese adults living with underweight, overweight or obesity is compounded by the unaffordability of a healthy MD. Improving the affordability of nutritious foods is crucial to promoting healthier dietary patterns and achieving better weight outcomes. Public health strategies should include economic, behavioural and policy-level interventions to enhance diet quality and affordability in crisis-affected populations. FAU - Hoteit, Maha AU - Hoteit M AD - Lebanese University, Lebanon. FAU - Abboud, Myriam AU - Abboud M AD - Zayed University, United Arab Emirates. FAU - Khattar, Maroun AU - Khattar M AD - Lebanese University, Lebanon. FAU - Rizk, Rana AU - Rizk R AUID- ORCID: 0000-0002-8850-6502 AD - Lebanese American Universityhttps://ror.org/00hqkan37, Lebanon. LA - eng PT - Journal Article DEP - 20260219 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Lebanon/epidemiology MH - Adult MH - Cross-Sectional Studies MH - Female MH - Male MH - *Body Mass Index MH - Middle Aged MH - Adolescent MH - *Thinness/epidemiology/economics MH - *Overweight/epidemiology/economics MH - *Obesity/epidemiology/economics MH - Young Adult MH - *Diet, Mediterranean/economics/statistics & numerical data MH - *Diet, Healthy/economics/statistics & numerical data MH - Prevalence PMC - PMC12979016 OTO - NOTNLM OT - Health OT - Lebanon OT - Mediterranean Diet OT - diet affordability OT - food insecurity OT - nutrition transition COIS- None. EDAT- 2026/02/19 17:35 MHDA- 2026/03/07 18:38 PMCR- 2026/02/19 CRDT- 2026/02/19 07:13 PHST- 2026/03/07 18:38 [medline] PHST- 2026/02/19 17:35 [pubmed] PHST- 2026/02/19 07:13 [entrez] PHST- 2026/02/19 00:00 [pmc-release] AID - S1368980026102092 [pii] AID - 10.1017/S1368980026102092 [doi] PST - epublish SO - Public Health Nutr. 2026 Feb 19;29(1):e42. doi: 10.1017/S1368980026102092. PMID- 41710594 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260219 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - Is it time to align adolescent diets with the Planetary Health Diet? An observational study on early cardiovascular health. PG - 1739577 LID - 10.3389/fnut.2025.1739577 [doi] LID - 1739577 AB - BACKGROUND: As the impact of early adoption of a sustainable plant-based diet on cardiometabolic biomarkers remains unexplored, we assessed whether they are associated with the Planetary Health Diet Index (PHDI) in adolescents. METHODS: This prospective study was conducted within the SI! Program for Secondary Schools trial (SI! Program) in 886 adolescents (12 years +/- 0.4 at cohort entry; 49.1% female) followed during 4 years in Spain. The PHDI scores were derived from validated food frequency questionnaires. Multivariable-adjusted Cox proportional-hazards models (HRs) analyzed the association between PHDI and risk of new-onset high blood pressure (BP), obesity, and elevated plasma cardiometabolic biomarkers. Additionally, mixed models assessed changes in those parameters. RESULTS: High adherence to the PHDI((Q4 vs. Q1)) is associated with a reduced risk of high BP by 81% (HR: 0.19 [95% CI: 0.11, 0.34]), plasma glucose by 47% (HR: 0.53 [95% CI: 0.48, 0.58]), triglycerides (TG) by 66% (HR: 0.34 [95% CI: 0.18, 0.65]), total cholesterol by 51% (HR: 0.49 [95% CI: 0.34, 0.69]), and non-high density lipoprotein cholesterol (non-HDL-C) by 74% (HR: 0.26 [95% CI: 0.13, 0.50]) in Cox models. Mixed models show inverse associations with higher PHDI and blood glucose (-5.23 mg/dL [95% CI: -10.35, -0.10]), TG (-2.48 mg/dL [95% CI: -3.65, -1.30]), and body mass index (BMI) z-score (-0.02 [95% CI: -0.03, 0.00]). CONCLUSION: This study stands out as greater adherence to the PHDI is inversely associated with cardiometabolic biomarkers in adolescents, highlighting nutritional benefits of the Planetary Health Diet and its role in preventing the development of cardiovascular diseases and early detection. CI - Copyright (c) 2026 Murcia-Lesmes, Laveriano-Santos, Estruch, Corrado, Arancibia-Riveros, Ruiz-Leon, Casas, Camafort, Martinez-Gomez, de Cos-Gandoy, Bodega, Santos-Beneit, Fernandez-Alvira, Fernandez-Jimenez, Lamuela-Raventos and Castro-Barquero. FAU - Murcia-Lesmes, David AU - Murcia-Lesmes D AD - Polyphenol Research Group, Departament de Nutricio, Ciencies de l'Alimentacio i Gastronomia, Facultat de Farmacia i Ciencies de l'Alimentacio, Barcelona, Spain. AD - Institut de Nutricio i Seguretat Alimentaria (INSA-UB), Universitat de Barcelona, Barcelona, Spain. FAU - Laveriano-Santos, Emily P AU - Laveriano-Santos EP AD - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. FAU - Estruch, Ramon AU - Estruch R AD - Institut de Nutricio i Seguretat Alimentaria (INSA-UB), Universitat de Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. AD - Department of Internal Medicine, Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain. FAU - Corrado, Marina AU - Corrado M AD - Polyphenol Research Group, Departament de Nutricio, Ciencies de l'Alimentacio i Gastronomia, Facultat de Farmacia i Ciencies de l'Alimentacio, Barcelona, Spain. AD - Institut de Nutricio i Seguretat Alimentaria (INSA-UB), Universitat de Barcelona, Barcelona, Spain. FAU - Arancibia-Riveros, Camila AU - Arancibia-Riveros C AD - Polyphenol Research Group, Departament de Nutricio, Ciencies de l'Alimentacio i Gastronomia, Facultat de Farmacia i Ciencies de l'Alimentacio, Barcelona, Spain. AD - Institut de Nutricio i Seguretat Alimentaria (INSA-UB), Universitat de Barcelona, Barcelona, Spain. FAU - Ruiz-Leon, Ana Maria AU - Ruiz-Leon AM AD - Institut de Nutricio i Seguretat Alimentaria (INSA-UB), Universitat de Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. AD - Department of Internal Medicine, Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain. FAU - Casas, Rosa AU - Casas R AD - Institut de Nutricio i Seguretat Alimentaria (INSA-UB), Universitat de Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. AD - Department of Internal Medicine, Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain. FAU - Camafort, Miguel AU - Camafort M AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. AD - Department of Internal Medicine, Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain. FAU - Martinez-Gomez, Jesus AU - Martinez-Gomez J AD - Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. FAU - de Cos-Gandoy, Amaya AU - de Cos-Gandoy A AD - Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. AD - Foundation for Science, Health and Education (SHE Foundation), Barcelona, Spain. FAU - Bodega, Patricia AU - Bodega P AD - Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. AD - Foundation for Science, Health and Education (SHE Foundation), Barcelona, Spain. FAU - Santos-Beneit, Gloria AU - Santos-Beneit G AD - Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. AD - Foundation for Science, Health and Education (SHE Foundation), Barcelona, Spain. FAU - Fernandez-Alvira, Juan M AU - Fernandez-Alvira JM AD - Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. FAU - Fernandez-Jimenez, Rodrigo AU - Fernandez-Jimenez R AD - Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. AD - CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. AD - Hospital Universitario Clinico San Carlos, IdISSC, Madrid, Spain. FAU - Lamuela-Raventos, Rosa M AU - Lamuela-Raventos RM AD - Polyphenol Research Group, Departament de Nutricio, Ciencies de l'Alimentacio i Gastronomia, Facultat de Farmacia i Ciencies de l'Alimentacio, Barcelona, Spain. AD - Institut de Nutricio i Seguretat Alimentaria (INSA-UB), Universitat de Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. FAU - Castro-Barquero, Sara AU - Castro-Barquero S AD - Institut de Nutricio i Seguretat Alimentaria (INSA-UB), Universitat de Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. AD - Department of Internal Medicine, Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain. LA - eng PT - Journal Article DEP - 20260203 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12911428 OTO - NOTNLM OT - Planetary Diet OT - adolescents OT - cardiovascular health OT - nutritional epidemiology OT - plant-based diet OT - prevention OT - prospective study OT - sustainability COIS- RL-R reports personal fees from Cerveceros de Espana, personal fees, and others from Adventia, UNIDECO SA, Wine in Moderation, Ecoveritas S.A., outside the submitted work. RE reports grants from the Spanish government, Fundacion Dieta Mediterranea (Spain), and Cerveza y Salud (Spain), and personal fees for given lectures from Brewers of Europe (Belgium), the Fundacion Cerveza y Salud (Spain), Pernaud-Ricard (Mexico), Instituto Cervantes (Alburquerque, USA), Instituto Cervantes (Milan, Italy), Instituto Cervantes (Tokyo, Japan), Lilly Laboratories (Spain), and the Wine and Culinary International Forum (Spain), as well as non-financial support for the organization of a National Congress on Nutrition and feeding trials with products from Grand Fountain and Uriach Laboratories (Spain). The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author RC declares that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/02/19 07:03 MHDA- 2026/02/19 07:04 PMCR- 2026/02/03 CRDT- 2026/02/19 04:51 PHST- 2025/11/04 00:00 [received] PHST- 2025/12/17 00:00 [revised] PHST- 2025/12/29 00:00 [accepted] PHST- 2026/02/19 07:04 [medline] PHST- 2026/02/19 07:03 [pubmed] PHST- 2026/02/19 04:51 [entrez] PHST- 2026/02/03 00:00 [pmc-release] AID - 10.3389/fnut.2025.1739577 [doi] PST - epublish SO - Front Nutr. 2026 Feb 3;12:1739577. doi: 10.3389/fnut.2025.1739577. eCollection 2025. PMID- 41710441 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1303-2968 (Electronic) IS - 1303-2968 (Linking) VI - 25 IP - 1 DP - 2026 Mar TI - The Role of Machine Learning in Talent Identification for Team Sports: A Systematic Review. PG - 58-83 LID - 10.52082/jssm.2026.58 [doi] AB - Talent identification (TID) in team sports is complex, influenced by biological, technical, psychological, and socio-cultural factors. Machine learning (ML) offers tools to integrate high-dimensional data, yet its applications in youth TID remain underexplored. Objectives: To systematically review ML approaches applied to youth talent identification in team sports, with emphasis on data domains, algorithms, validation strategies, and interpretability. Eligible studies included peer-reviewed quantitative research applying ML to youth athletes (/= 10 events/h is a recommended criterion. This study aimed to assess the incidence and risk factors of early postoperative respiratory complications in children undergoing tonsillectomy for OSA with planned ICU admission. We conducted an observational study of children undergoing tonsillectomy between January 2020 and December 2022, with a preoperative ICU indication. Respiratory events were defined as a need of oxygen therapy, noninvasive ventilation (NIV), or tracheal intubation. Collected data included anthropometrics, comorbidities, AHI, gas exchange parameters, and surgical details. Univariate and multivariate analyses were performed for potential risk factors associated with postoperative respiratory complications. 166 children were included (median age 3 years [IQR 2-5]). The median preoperative AHI was 25 events/hour [13-43]. Overall, 159 (96%) patients had at least one comorbidity (45 Down syndrome, 31 obesity and 25 craniofacial malformations). Thirty-four (21%) patients had a respiratory complication: 30 needed oxygen therapy, 4 required NIV. None required an intubation. Age (p < 0.001), percentage of sleep time spent with an Oxygen saturation level < 85% (T85) and < 90% (T90) (p = 0.02 and p = 0.03, respectively) and McGill Oximetry Score (p = 0.01) were significantly associated with respiratory events, whereas neither AHI nor comorbidities showed a significant association. Conclusion: This study highlights the limited value of AHI alone in predicting respiratory complications post-tonsillectomy. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Gozlan, Romane AU - Gozlan R AD - Pediatric Otolaryngology Department, APHP, Hopital Necker-Enfants Malades, 149 Rue de Sevres, 75015, Paris, France. FAU - Lisan, Quentin AU - Lisan Q AD - Otolaryngology Department, Foch Hospital, 92150, Suresnes, France. FAU - Vergnaud, Estelle AU - Vergnaud E AD - Department of Paediatric Anaesthesia and Intensive Care, APHP, Hopital Necker-Enfants Malades, 75015, Paris, France. FAU - Crowe, Ann-Marie AU - Crowe AM AD - Department of Paediatric Anaesthesia and Intensive Care, APHP, Hopital Necker-Enfants Malades, 75015, Paris, France. FAU - Griffon, Lucie AU - Griffon L AD - Pediatric Sleep and Noninvasive Ventilation Unit, AP-HP, Hopital Necker-Enfants Malades, 75015, Paris, France. FAU - Fauroux, Brigitte AU - Fauroux B AD - Pediatric Sleep and Noninvasive Ventilation Unit, AP-HP, Hopital Necker-Enfants Malades, 75015, Paris, France. AD - UMR 7330 VIFASOM (Vigilance Fatigue Sommeil Et Sante Publique), Paris Cite University, 75006, Paris, France. FAU - Couloigner, Vincent AU - Couloigner V AD - Pediatric Otolaryngology Department, APHP, Hopital Necker-Enfants Malades, 149 Rue de Sevres, 75015, Paris, France. AD - Faculte de Medecine, Paris Cite University, 75006, Paris, France. FAU - Orliaguet, Gilles AU - Orliaguet G AD - Department of Paediatric Anaesthesia and Intensive Care, APHP, Hopital Necker-Enfants Malades, 75015, Paris, France. AD - Faculte de Medecine, Paris Cite University, 75006, Paris, France. AD - UMR7323 << Pharmacologie Et Evaluation Des Therapeutiques Chez L'enfant Et La Femme Enceinte >>, INSERM, Universite Paris Cite, Paris, France. FAU - Thierry, Briac AU - Thierry B AD - Pediatric Otolaryngology Department, APHP, Hopital Necker-Enfants Malades, 149 Rue de Sevres, 75015, Paris, France. AD - Faculte de Medecine, Paris Cite University, 75006, Paris, France. FAU - Luscan, Romain AU - Luscan R AUID- ORCID: 0000-0003-1219-727X AD - Pediatric Otolaryngology Department, APHP, Hopital Necker-Enfants Malades, 149 Rue de Sevres, 75015, Paris, France. romain.luscan@aphp.fr. AD - Faculte de Medecine, Paris Cite University, 75006, Paris, France. romain.luscan@aphp.fr. LA - eng PT - Journal Article PT - Observational Study DEP - 20260216 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Tonsillectomy/adverse effects MH - *Sleep Apnea, Obstructive/surgery MH - Risk Factors MH - Female MH - Incidence MH - Child, Preschool MH - Male MH - *Postoperative Complications/epidemiology/etiology MH - France/epidemiology MH - Child OTO - NOTNLM OT - Apnea-hypopnea index OT - Intensive care unit OT - McGill score OT - Oximetry OT - Pediatric OSA OT - Respiratory events OT - Tonsillectomy COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/02/17 00:53 MHDA- 2026/02/17 00:54 CRDT- 2026/02/16 23:26 PHST- 2025/12/17 00:00 [received] PHST- 2026/02/09 00:00 [accepted] PHST- 2026/02/02 00:00 [revised] PHST- 2026/02/17 00:54 [medline] PHST- 2026/02/17 00:53 [pubmed] PHST- 2026/02/16 23:26 [entrez] AID - 10.1007/s00431-026-06796-8 [pii] AID - 10.1007/s00431-026-06796-8 [doi] PST - epublish SO - Eur J Pediatr. 2026 Feb 16;185(3):135. doi: 10.1007/s00431-026-06796-8. PMID- 41699110 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260920 IS - 1433-7339 (Electronic) IS - 0941-4355 (Print) IS - 0941-4355 (Linking) VI - 34 IP - 3 DP - 2026 Feb 17 TI - Lipidomic profiles associated with treatment related hepatotoxicity in children with acute lymphoblastic leukemia. PG - 209 LID - 10.1007/s00520-026-10414-6 [doi] LID - 209 AB - INTRODUCTION: Treatment for childhood acute lymphoblastic leukemia (ALL) can result in hepatotoxicity. Despite being a common complication of ALL therapy, mechanisms and biomarkers of treatment-associated hepatotoxicity (TAH) are not well described. METHODS: We conducted lipidomic profiling to identify plasma lipids associated with TAH in children receiving ALL therapy utilizing a nested case-control framework. TAH was defined as (1) transaminitis: ALT/AST >/= CTCAE grade 3, and/or (2) conjugated hyperbilirubinemia: > 3.0 mg/dL during induction therapy or > 2.0 mg/dL post induction. A total of 90 patients (45 matched pairs) treated at Texas Children's Hospital between 2012 and 2021 were selected for lipidomic profiling, with controls matched to cases based on the availability of samples collected at similar time points in therapy. Lipidomic profiling quantified 1056 lipids, with 751 retained after quality control. Associations with TAH were evaluated using multivariable conditional logistic regression controlling for age, diagnostic BMI z-score, race/ethnicity, and induction intensity. RESULTS: The cohort was 55% male, 50% Hispanic, with a mean diagnostic age of 5 years. We identified 110 lipids nominally associated with TAH post-sample collection (p < 0.05). Lipid classes phosphatidylcholines (PCs; Holm-p = 5 x 10(-6)) and sphingomyelins (SMs; Holm-p = 0.0009) were significantly enriched in cases. DISCUSSION: We identified plasma lipid profiles, characterized by elevated PCs and SMs with reduced triglycerides, associated with the incidence of TAH in children with ALL. Similar patterns have been linked to metabolic liver disease in adults and children. These findings suggest lipid dysregulation may contribute to TAH susceptibility and highlight candidate biomarkers for future validation in larger cohorts. CI - (c) 2026. The Author(s). FAU - Mason, Emily J AU - Mason EJ AD - Baylor College of Medicine, One Baylor Plaza, BCM 622, Houston, TX, 77030, USA. AD - Texas Children's Cancer and Hematology Center, Houston, TX, USA. FAU - Schraw, Jeremy M AU - Schraw JM AD - Baylor College of Medicine, One Baylor Plaza, BCM 622, Houston, TX, 77030, USA. AD - Texas Children's Cancer and Hematology Center, Houston, TX, USA. FAU - Woodhouse, John P AU - Woodhouse JP AD - Baylor College of Medicine, One Baylor Plaza, BCM 622, Houston, TX, 77030, USA. AD - Texas Children's Cancer and Hematology Center, Houston, TX, USA. FAU - Gramatges, M Monica AU - Gramatges MM AD - Baylor College of Medicine, One Baylor Plaza, BCM 622, Houston, TX, 77030, USA. AD - Texas Children's Cancer and Hematology Center, Houston, TX, USA. FAU - Williams, Kevin J AU - Williams KJ AD - University of California Los Angeles, Los Angeles, CA, USA. FAU - Chen, Baojiang AU - Chen B AD - University of Texas School of Public Health, Houston, TX, USA. FAU - Harrell, Melissa B AU - Harrell MB AD - University of Texas School of Public Health, Houston, TX, USA. FAU - Taylor, Olga A AU - Taylor OA AD - Emory School of Medicine, Atlanta, GA, USA. FAU - Scheurer, Michael E AU - Scheurer ME AD - Emory School of Medicine, Atlanta, GA, USA. FAU - Lupo, Philip J AU - Lupo PJ AD - Emory School of Medicine, Atlanta, GA, USA. FAU - Rabin, Karen R AU - Rabin KR AD - University of California San Francisco, San Francisco, CA, USA. FAU - Yi, Joanna S AU - Yi JS AD - Baylor College of Medicine, One Baylor Plaza, BCM 622, Houston, TX, 77030, USA. AD - Texas Children's Cancer and Hematology Center, Houston, TX, USA. FAU - Huynh, Van AU - Huynh V AD - Children's Hospital of Orange County (CHOC), Orange, CA, USA. FAU - Mittelman, Steven D AU - Mittelman SD AD - University of California Los Angeles, Los Angeles, CA, USA. FAU - Orgel, Etan AU - Orgel E AD - Children's Hospital of Los Angeles, Los Angeles, CA, USA. FAU - Brown, Austin AU - Brown A AD - Baylor College of Medicine, One Baylor Plaza, BCM 622, Houston, TX, 77030, USA. austin.brown@bcm.edu. AD - Texas Children's Cancer and Hematology Center, Houston, TX, USA. austin.brown@bcm.edu. LA - eng GR - P20 CA262733/CA/NCI NIH HHS/United States GR - U54 CA302464/CA/NCI NIH HHS/United States GR - UH3 CA260607/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20260217 PL - Germany TA - Support Care Cancer JT - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer JID - 9302957 RN - 0 (Lipids) RN - 0 (Biomarkers) RN - 0 (Antineoplastic Agents) SB - IM MH - Humans MH - *Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy MH - Male MH - Child, Preschool MH - Female MH - *Lipidomics MH - *Chemical and Drug Induced Liver Injury/etiology/epidemiology/blood MH - Child MH - Case-Control Studies MH - Infant MH - *Lipids/blood MH - Biomarkers/blood MH - Adolescent MH - *Antineoplastic Agents/adverse effects MH - Texas MH - Logistic Models PMC - PMC12909625 OTO - NOTNLM OT - Acute lymphoblastic leukemia OT - Lipidomic profiling OT - Treatment-associated hepatotoxicity COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/02/17 00:53 MHDA- 2026/02/17 00:54 PMCR- 2026/02/17 CRDT- 2026/02/16 23:26 PHST- 2025/11/20 00:00 [received] PHST- 2026/01/29 00:00 [accepted] PHST- 2026/02/17 00:54 [medline] PHST- 2026/02/17 00:53 [pubmed] PHST- 2026/02/16 23:26 [entrez] PHST- 2026/02/17 00:00 [pmc-release] AID - 10.1007/s00520-026-10414-6 [pii] AID - 10414 [pii] AID - 10.1007/s00520-026-10414-6 [doi] PST - epublish SO - Support Care Cancer. 2026 Feb 17;34(3):209. doi: 10.1007/s00520-026-10414-6. PMID- 41697175 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260730 IS - 1879-1972 (Electronic) IS - 1054-139X (Linking) VI - 78 IP - 6 DP - 2026 Jun TI - Toward Earlier Bedtimes: Randomized Trial of Multi-Method Interventions in a Community Cohort of Adolescents. PG - 854-864 LID - S1054-139X(25)00817-1 [pii] LID - 10.1016/j.jadohealth.2025.12.247 [doi] AB - PURPOSE: Many adolescents develop very late circadian rhythms, indicating delayed sleep phase. Interventions are sparse, and the stability of any improvements is rarely reported. To evaluate how late sleep patterns can be improved, we performed a randomized control trial among adolescents. Overall, 4-6-week intervention modes included bright light therapy (BLT), personalized sleep coaching, or their combination (BLSC), and an active control group receiving information. METHODS: We measured the sleep and circadian patterns of 288 adolescents (17 years) born in years 1999-2000. A sub-sample (n = 176) that weighted on late sleep rhythms participated in the randomized control trial. Sleep, circadian temperature patterns, depressive symptoms, anxiety, and sleep hygiene were measured at baseline (T1) after the intervention (T2) and after 1 year (T3) with GeneActiv Original actigraphy, ibutton 1922L thermologgers, and validated questionnaires. RESULTS: Participants in the SC group significantly increased their sleep duration compared to the control group, 23 minutes from T1 to T2 and 33 minutes from T1 to T3 (p < .03). They also improved their sleep hygiene from T1 to T2 (p = .019), but this did not persist to T3. Other groups did not improve their sleep patterns. DISCUSSION: Although personalized sleep coaching resulted in persistently longer sleep, none of the interventions were successful in overcoming late sleep rhythms among an adolescent sample derived from the population register. Delayed sleep phase is a persistent condition with biological components, and a 4-week intervention is presumably too short for changing sleep behavior and rhythms. Clinical Trials number 1287174/NCT02964598. CI - Copyright (c) 2025 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved. FAU - Kuula, Liisa AU - Kuula L AD - Faculty of Medicine, SleepWell Research Program, University of Helsinki, Helsinki, Finland; Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland. Electronic address: liisa.kuula@helsinki.fi. FAU - Pesonen, Anu-Katriina AU - Pesonen AK AD - Faculty of Medicine, SleepWell Research Program, University of Helsinki, Helsinki, Finland. LA - eng SI - ClinicalTrials.gov/NCT02964598 PT - Journal Article PT - Randomized Controlled Trial DEP - 20260216 PL - United States TA - J Adolesc Health JT - The Journal of adolescent health : official publication of the Society for Adolescent Medicine JID - 9102136 SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - Sleep Duration MH - *Circadian Rhythm/physiology MH - *Sleep/physiology MH - *Phototherapy/methods MH - Actigraphy MH - Sleep Hygiene MH - Surveys and Questionnaires EDAT- 2026/02/16 12:30 MHDA- 2026/05/13 00:29 CRDT- 2026/02/16 10:28 PHST- 2025/04/25 00:00 [received] PHST- 2025/11/28 00:00 [revised] PHST- 2025/12/01 00:00 [accepted] PHST- 2026/05/13 00:29 [medline] PHST- 2026/02/16 12:30 [pubmed] PHST- 2026/02/16 10:28 [entrez] AID - S1054-139X(25)00817-1 [pii] AID - 10.1016/j.jadohealth.2025.12.247 [doi] PST - ppublish SO - J Adolesc Health. 2026 Jun;78(6):854-864. doi: 10.1016/j.jadohealth.2025.12.247. Epub 2026 Feb 16. PMID- 41694709 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260216 LR - 20260218 IS - 1745-0179 (Print) IS - 1745-0179 (Electronic) IS - 1745-0179 (Linking) VI - 21 DP - 2025 TI - Objective Assessment of Attention Deficit Hyperactivity Disorder with QbMobile: A Smartphone Application for Clinical Use. PG - e17450179444324 LID - 10.2174/0117450179444324251118134538 [doi] LID - e17450179444324 AB - INTRODUCTION: Digital mental health interventions such as web or mobile applications have become more prominent in the last years to improve the clinical assessment and workflow in mental health disorders while also being potentially more accessible than laptops. QbMobile is a software application that provides objective assessments of hyperactivity, impulsivity, and inattention to aid in the clinical evaluation of attention deficit hyperactivity disorder (ADHD). The purpose was to examine whether QbMobile could objectively quantify symptoms and reveal significant clinical differences between an ADHD population and a normative population. METHODS: Data were acquired from two low-intervention/observational studies (conducted in Europe and US), involving participants aged 6 to 60 years. The application (QbMobile) was configured on the smartphone (iPhone) with embedded instructions to ensure a consistent experience. Participants were seated at a desk in a stabilized chair and instructed to hold the smartphone with both hands and to tap the screen whenever an infrequent target stimulus appeared, while withholding a response to non-target stimuli. Concurrently, to measure activity, the camera of the smartphone captured the physical activity of the participant as well as the movements from holding the device. Approximately 20% of the complete dataset for each study was combined as a pooled dataset for a model validation of output parameters from QbMobile. A Total Score between 0 and 100 was calculated, where lower scores indicate a lower likelihood of ADHD symptoms and higher scores indicate a higher likelihood. RESULTS: The ADHD cohort (n=63) demonstrated a higher mean Total Score of 83.0 (Standard deviation=17.5) compared to 48.9 (Standard deviation=18.8) in the normative population (n=354), a difference that was statistically significant (p<0.001). Significant domain-specific differences in SD-scores (movement pattern, activity, impulsivity, inattention) were identified between the ADHD cohort and the normative comparison group (p<0.001). A sensitivity of 0.86 and specificity of 0.75 were seen overall, though a low specificity was found in children, which was likely due to a smaller sample size and high activity levels in younger children in general. DISCUSSION: This investigation demonstrates that QbMobile can generate objective symptom measurements that distinguish clinically relevant differences between individuals with ADHD and a normative population. A smartphone application of quantified behavioral psychometric testing of the core symptoms could streamline a faster diagnostic evaluation and treatment titration in the ADHD clinical workflow. The authors are employed by the manufacturer of QbMobile, which is discussed in this manuscript. This affiliation is disclosed to ensure transparency and does not affect the objectivity or scientific integrity of the work presented. CONCLUSION: QbMobile demonstrated the ability to differentiate between ADHD and normative cohorts, indicating its potential as an accessible and objective tool for clinical assessment and treatment evaluation. Future studies should be conducted to further validate the effectiveness of QbMobile as an aid tool in the clinical assessment of ADHD and further explore its use in various populations. CI - (c) 2025 The Author(s). Published by Bentham Open. FAU - Gustafsson, Urban AU - Gustafsson U AUID- ORCID: 0000-0002-4571-8062 AD - Qbtech AB, Medical Department, Cardellgatan 1, 11436 Stockholm, Sweden. FAU - Larsson, Simon AU - Larsson S AD - Qbtech AB, Medical Department, Cardellgatan 1, 11436 Stockholm, Sweden. FAU - Casals, Nuria AU - Casals N AD - Qbtech AB, Medical Department, Cardellgatan 1, 11436 Stockholm, Sweden. FAU - Nolen, Robert AU - Nolen R AD - Qbtech, Inc., Medical Department, 8 Greenway Plaza, Suite 750, Houston, TX 77046, United States. FAU - Sanyal, Ragini Yallampalli AU - Sanyal RY AD - Qbtech, Inc., Medical Department, 8 Greenway Plaza, Suite 750, Houston, TX 77046, United States. FAU - Hansen, Mikkel AU - Hansen M AD - Qbtech AB, Medical Department, Cardellgatan 1, 11436 Stockholm, Sweden. LA - eng PT - Journal Article DEP - 20251122 PL - United Arab Emirates TA - Clin Pract Epidemiol Ment Health JT - Clinical practice and epidemiology in mental health : CP & EMH JID - 101245735 PMC - PMC12895433 OTO - NOTNLM OT - Attention deficit hyperactivity disorder OT - Mental health interventions OT - Psychometric test OT - QbMobile OT - QbTest OT - Smartphone COIS- The authors are employed at either Qbtech AB, Stockholm, Sweden or Qbtech, Inc. Houston, TX, USA, the company that manufactures QbMobile. The writing and evaluation of the manuscript was developed within the medical department but was not influenced by Qbtech AB'. EDAT- 2026/02/16 12:32 MHDA- 2026/02/16 12:33 PMCR- 2025/11/22 CRDT- 2026/02/16 06:44 PHST- 2025/09/24 00:00 [received] PHST- 2025/10/21 00:00 [revised] PHST- 2025/11/05 00:00 [accepted] PHST- 2026/02/16 12:33 [medline] PHST- 2026/02/16 12:32 [pubmed] PHST- 2026/02/16 06:44 [entrez] PHST- 2025/11/22 00:00 [pmc-release] AID - CPEMH-21-E17450179444324 [pii] AID - 10.2174/0117450179444324251118134538 [doi] PST - epublish SO - Clin Pract Epidemiol Ment Health. 2025 Nov 22;21:e17450179444324. doi: 10.2174/0117450179444324251118134538. eCollection 2025. PMID- 41694472 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260216 LR - 20260218 IS - 1976-1457 (Print) IS - 2005-6168 (Electronic) IS - 1976-1457 (Linking) VI - 20 IP - 1 DP - 2026 Feb TI - Development and usability evaluation of a web-based healthy eating practice questionnaire for Korean preschool children: a child-parent dyad approach. PG - 132-144 LID - 10.4162/nrp.2026.20.1.132 [doi] AB - BACKGROUND/OBJECTIVES: The illustrated Healthy Eating Practice Questionnaire (HEPQ) was previously developed to assess food preferences, eating behaviors, hand/oral hygiene practices, and nutrition knowledge among Korean preschool children. Nevertheless, the lack of an integrated scoring system has limited its interpretability. This study developed a scoring system and a web-based platform with tailored feedback using a child-parent dyad approach. SUBJECTS/METHODS: The development process consisted of 5 phases: 1) questionnaire preparation for online use, 2) formulation of the scoring system, 3) determination of the cut-off values for three levels of healthy eating practices based on a child-parent survey, 4) technical development of the online platform, and 5) usability evaluation. A scoring system was established by standardizing the domain scores to a 100-point scale. One hundred child-parent pairs participated in the survey to calculate the Healthy Eating Practice Score (HEPS) and determine cut-off values for the HEPS levels. The validity of the cut-off values was examined by a comparison with the Nutrition Quotient for Preschoolers (NQ-P). A web-based platform was developed, and 47 child-parent pairs were used to assess its usability. RESULTS: Significant positive correlations were observed between child and parent HEPS across all domains. The HEPS-based classification showed good discriminative ability because higher HEPS levels were consistently associated with higher NQ-P scores in children and parents. The web-based HEPQ was easy to use and understand, and almost all participants (97.9% of children and 93.6% of parents) reported no difficulties using the platform. CONCLUSION: The web-based HEPQ platform with an integrated scoring system provides a valid, user-friendly tool for assessing and interpreting healthy eating practices in preschool children. This platform supports parental engagement in children's healthy eating practices and provides a practical tool for evaluating the effectiveness of nutrition education in early childcare settings. CI - (c)2026 The Korean Nutrition Society and the Korean Society of Community Nutrition. FAU - Han, Young-Hee AU - Han YH AUID- ORCID: 0000-0003-1869-5675 AD - Department of Food and Nutrition, Chungbuk National University, Cheongju 28644, Korea. FAU - Park, Dawon AU - Park D AUID- ORCID: 0009-0004-0135-3366 AD - Department of Food and Nutrition, Chungbuk National University, Cheongju 28644, Korea. FAU - Kim, Dahyeon AU - Kim D AUID- ORCID: 0009-0003-0336-1266 AD - Department of Food and Nutrition, Chungbuk National University, Cheongju 28644, Korea. FAU - Shin, Saerom AU - Shin S AUID- ORCID: 0000-0003-1532-7228 AD - National Institute of Food & Nutrition Service, Cheongju 28160, Korea. FAU - Woo, Eun Yeol AU - Woo EY AUID- ORCID: 0000-0003-0686-3272 AD - National Institute of Food & Nutrition Service, Cheongju 28160, Korea. FAU - Park, Hye-Kyung AU - Park HK AUID- ORCID: 0000-0003-4864-3999 AD - National Institute of Food & Nutrition Service, Cheongju 28160, Korea. FAU - Hyun, Taisun AU - Hyun T AUID- ORCID: 0000-0002-6888-1612 AD - Department of Food and Nutrition, Chungbuk National University, Cheongju 28644, Korea. LA - eng PT - Journal Article DEP - 20260130 PL - Korea (South) TA - Nutr Res Pract JT - Nutrition research and practice JID - 101311052 PMC - PMC12893856 OTO - NOTNLM OT - Preschool children OT - eating behavior OT - food preferences OT - online systems OT - questionnaire COIS- Conflict of Interest: The authors declare no potential conflicts of interests. EDAT- 2026/02/16 12:30 MHDA- 2026/02/16 12:31 PMCR- 2026/02/01 CRDT- 2026/02/16 06:40 PHST- 2026/01/05 00:00 [received] PHST- 2026/01/20 00:00 [revised] PHST- 2026/01/21 00:00 [accepted] PHST- 2026/02/16 12:31 [medline] PHST- 2026/02/16 12:30 [pubmed] PHST- 2026/02/16 06:40 [entrez] PHST- 2026/02/01 00:00 [pmc-release] AID - 10.4162/nrp.2026.20.1.132 [doi] PST - ppublish SO - Nutr Res Pract. 2026 Feb;20(1):132-144. doi: 10.4162/nrp.2026.20.1.132. Epub 2026 Jan 30. PMID- 41693999 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260216 LR - 20260218 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Influence of family support on leisure activities and mental health in times of health crisis. PG - 1736074 LID - 10.3389/fpsyg.2026.1736074 [doi] LID - 1736074 AB - Physical activity is an essential pillar for promoting health and comprehensive well-being throughout life. During the COVID-19 pandemic, lockdown and social restriction measures significantly transformed family routines and lifestyles, leading to an increase in sedentary behavior and negative effects on mental health. This article aims to analyze the influence of family support on mental health, mediated by physical activity and sedentary behaviors during the COVID-19 lockdown. A total of 1,345 Mexican adults (68.1% women) participated, responding to validated instruments: the Social Support for Physical Activity Scale, the Godin-Shephard Leisure-Time Physical Activity Questionnaire, the Youth Leisure-Time Sedentary Behavior Questionnaire, and the Positive and Negative Affect Schedule (PANAS). Structural equation modeling analyses showed a satisfactory model fit (chi(2)/df = 6.71, CFI = 0.931, RMSEA = 0.060). Family support was positively associated with active leisure and, more weakly, with passive leisure. Furthermore, active leisure was related to greater positive affect, while passive leisure was associated with psychological distress. These results highlight the protective role of the family in promoting physical activity and emotional regulation in lockdown contexts. It is recommended to design family intervention programs that integrate educational, affective, and behavioral components to foster active lifestyles and strengthen resilience for future health crises. CI - Copyright (c) 2026 Garcia-Gallegos, Delgado-Herrada, Morquecho-Sanchez, Leale and Zamarripa. FAU - Garcia-Gallegos, Janeth Berenice AU - Garcia-Gallegos JB AD - Universidad Autonoma de Occidente, Unidad Regional Guasave, Culiacan, Mexico. FAU - Delgado-Herrada, Maritza AU - Delgado-Herrada M AD - Secretaria de Ciencia, Humanidades, Tecnologia e Innovacion (SECIHTI), Mexico City, Mexico. FAU - Morquecho-Sanchez, Raquel AU - Morquecho-Sanchez R AD - Facultad de Organizacion Deportiva, Universidad Autonoma de Nuevo Leon, Nuevo Leon, Mexico. FAU - Leale, Ignazio AU - Leale I AD - Department of Psychology, Educational Sciences and Human Movement, Sport and Exercise Research Unit, Palermo, Italy. FAU - Zamarripa, Jorge AU - Zamarripa J AD - Facultad de Organizacion Deportiva, Universidad Autonoma de Nuevo Leon, Nuevo Leon, Mexico. LA - eng PT - Journal Article DEP - 20260129 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC12904146 OTO - NOTNLM OT - COVID-19 OT - Mexico OT - family support OT - lockdown OT - physical activity OT - sedentary behaviors COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor DMS declared a past co-authorship with the author IL. EDAT- 2026/02/16 12:31 MHDA- 2026/02/16 12:32 PMCR- 2026/01/29 CRDT- 2026/02/16 06:37 PHST- 2025/10/30 00:00 [received] PHST- 2025/12/17 00:00 [revised] PHST- 2026/01/09 00:00 [accepted] PHST- 2026/02/16 12:32 [medline] PHST- 2026/02/16 12:31 [pubmed] PHST- 2026/02/16 06:37 [entrez] PHST- 2026/01/29 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1736074 [doi] PST - epublish SO - Front Psychol. 2026 Jan 29;17:1736074. doi: 10.3389/fpsyg.2026.1736074. eCollection 2026. PMID- 41693527 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260721 IS - 1755-5949 (Electronic) IS - 1755-5930 (Print) IS - 1755-5930 (Linking) VI - 32 IP - 2 DP - 2026 Feb TI - Digital Sleep Disruption: Unraveling the Network Structure of Technology Use and Sleep Problems Through Network Analysis. PG - e70778 LID - 10.1002/cns.70778 [doi] LID - e70778 AB - BACKGROUND: Sleep problems have emerged as a critical health concern in the digital age, yet the complex mechanisms linking technology use to sleep disruption remain poorly understood. Previous research has typically examined isolated relationships between specific technological behaviors and sleep outcomes, overlooking the complex interplay among various digital factors. This study aims to address this gap by employing network analysis to investigate the interconnected relationships among multiple technology-related factors and their collective influence on sleep problems. METHODS: Using network analysis, this study examined how different aspects of digital technology use collectively influence sleep problems in a large sample of Chinese adults (N = 9443). Participants were recruited through stratified random sampling based on age groups and geographical regions, with the sample size determined a priori using Monte Carlo simulations to ensure stable network estimation. Participants completed validated measures assessing screen time, before-bed electronic device use, electronic device dependency, social media anxiety, digital information overload, virtual social pressure, blue light exposure, circadian rhythm disruption, online gaming addiction, work-life digital integration, and sleep problems. Participants with diagnosed sleep disorders, those engaged in shift work, or those who had traveled across time zones in the past month were excluded to minimize confounding effects on natural sleep patterns. RESULTS: Network analysis revealed complex interconnections among technology-related factors and sleep problems. Blue light exposure demonstrated the strongest direct edge weight with sleep problems (r = 0.31, p < 0.001), followed by circadian rhythm disturbance (r = 0.26, p < 0.001). The network structure indicated that screen time, bedtime device use, electronic device dependence, virtual social pressure, and work-life digital integration showed weaker direct associations with sleep problems but demonstrated substantial indirect pathways through intermediate variables. Online gaming addiction, digital information overload, social media anxiety, and circadian rhythm disturbance exhibited moderate centrality indices, suggesting their role as potential mediators within the network. CONCLUSIONS: These findings advance our understanding of technology-induced sleep disruption and suggest potential targets for intervention. The network approach reveals that addressing sleep problems in the digital age requires consideration of both direct physiological impacts and indirect psychological pathways. The identification of specific factors with high centrality provides empirical guidance for developing targeted intervention strategies. CI - (c) 2026 The Author(s). CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd. FAU - Gan, Haoqing AU - Gan H AD - Department of Emergency, Shaoxing Second Hospital, Shaoxing, Zhejiang, China. AD - School of Medicine, Shaoxing University, Shaoxing, Zhejiang, China. FAU - Xu, Lingjia AU - Xu L AUID- ORCID: 0000-0002-9635-2056 AD - School of Medicine, Shaoxing University, Shaoxing, Zhejiang, China. AD - Department of Neurology, Shaoxing Second Hospital, Shaoxing, Zhejiang, China. FAU - Tong, Chenglin AU - Tong C AUID- ORCID: 0009-0008-3996-417X AD - Department of Emergency, Shaoxing Second Hospital, Shaoxing, Zhejiang, China. AD - School of Medicine, Shaoxing University, Shaoxing, Zhejiang, China. LA - eng GR - 2025KY402/the Medical and Health Research Projects of Health Commission of Zhejiang Province/ PT - Journal Article PL - England TA - CNS Neurosci Ther JT - CNS neuroscience & therapeutics JID - 101473265 SB - IM MH - Humans MH - *Sleep Wake Disorders/epidemiology/psychology/etiology MH - Female MH - Digital Media MH - Male MH - Adult MH - Young Adult MH - *Digital Technology MH - Circadian Rhythm MH - Middle Aged MH - Adolescent MH - Blue Light PMC - PMC12907764 OTO - NOTNLM OT - blue light exposure OT - circadian rhythm OT - digital technology OT - network analysis OT - psychological mechanisms OT - sleep problems COIS- The authors declare no conflicts of interest. EDAT- 2026/02/16 06:30 MHDA- 2026/02/16 06:31 PMCR- 2026/02/16 CRDT- 2026/02/16 04:42 PHST- 2026/01/21 00:00 [revised] PHST- 2025/10/23 00:00 [received] PHST- 2026/01/27 00:00 [accepted] PHST- 2026/02/16 06:31 [medline] PHST- 2026/02/16 06:30 [pubmed] PHST- 2026/02/16 04:42 [entrez] PHST- 2026/02/16 00:00 [pmc-release] AID - CNS70778 [pii] AID - 10.1002/cns.70778 [doi] PST - ppublish SO - CNS Neurosci Ther. 2026 Feb;32(2):e70778. doi: 10.1002/cns.70778. PMID- 41693143 OWN - NLM STAT- MEDLINE DCOM- 20260608 LR - 20260609 IS - 1099-0968 (Electronic) IS - 1072-4133 (Linking) VI - 34 IP - 4 DP - 2026 Jul TI - Assessment of Maladaptive Exercise History Among Individuals With Eating Disorders: Validation of a Brief, Self-Report Measure. PG - 1003-1015 LID - 10.1002/erv.70084 [doi] AB - OBJECTIVE: Maladaptive exercise is a common symptom of eating disorders (EDs). While several measures exist to assess current maladaptive exercise, there are no validated self-report tools to assess maladaptive exercise history-an important symptom domain among individuals with lifetime EDs. METHOD: Using data from a large sample of individuals with at least one lifetime ED diagnosis across four countries (N = 31,670), the current study aimed to validate and refine the Eating Disorders 100,000 Questionnaire-version 3 exercise items to create a brief measure of lifetime and current maladaptive exercise, suitable for large-scale epidemiological research and clinical screenings. RESULTS: Five non-redundant operationalisations of maladaptive exercise were identified ('Any Maladaptive Exercise', 'Regular Maladaptive Exercise', 'Compensatory Exercise', 'Excessive Exercise', 'Current Maladaptive Exercise'). Maladaptive exercise history was present across all lifetime ED presentations assessed, though endorsement levels varied based on scoring operationalisation. Individuals reporting a history of anorexia nervosa reported the highest levels of endorsement of most constructs, closely followed by bulimia nervosa. Compensatory exercise was endorsed most frequently among those reporting a history of bulimia nervosa relative to other diagnostic groups. CONCLUSIONS: Six key items were recommended as a brief screening assessment to capture maladaptive exercise history in EDs. TRIAL REGISTRATION: EDGI is a registered clinical trial (clinicaltrials.gov ID: NCT04378101). CI - (c) 2026 The Author(s). European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd. FAU - Schaumberg, Katherine AU - Schaumberg K AD - Department of Psychology, University of Texas at Austin, Austin, Texas, USA. AD - Department of Psychiatry, University of Wisconsin, Madison, Wisconsin, USA. FAU - Watson, Hunna J AU - Watson HJ AUID- ORCID: 0000-0001-8405-381X AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Discipline of Psychology, School of Population Health, Curtin University, Bentley, Australia. AD - Division of Paediatrics, School of Medicine, University of Western Australia, Perth, Australia. FAU - Thornton, Laura M AU - Thornton LM AUID- ORCID: 0000-0001-9384-7988 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Kennedy, Hannah L AU - Kennedy HL AD - Department of Psychological Medicine, University of Otago Christchurch, Christchurch, New Zealand. FAU - Ong, Shu H AU - Ong SH AD - InsideOut Institute for Eating Disorders, The University of Sydney, Sydney, Australia. FAU - Roche, Preston AU - Roche P AD - Department of Psychiatry, University of Texas-San Antonio, San Antonio, Texas, USA. FAU - Costello, Kayla AU - Costello K AUID- ORCID: 0000-0002-5486-9647 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Department of Psychology, University at Albany, State University of New York, Albany, New York, USA. FAU - Barnhart, Wesley R AU - Barnhart WR AUID- ORCID: 0000-0002-9809-5225 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Department of Psychology, Bowling Green State University, Bowling Green, Ohio, USA. AD - Suffolk University, Boston, Massachusetts, USA. FAU - Pauley-Gadd, Sian B AU - Pauley-Gadd SB AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Faculty of Health Sciences, enAble Institute, Curtin University, Bentley, Australia. FAU - Flatt, Rachael E AU - Flatt RE AUID- ORCID: 0000-0002-2661-7987 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Birgegard, Andreas AU - Birgegard A AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Dinkler, Lisa AU - Dinkler L AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Abbaspour, Afrouz AU - Abbaspour A AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Mantilla, Emma Forsen AU - Mantilla EF AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. AD - Department of Physical Activity and Health, Swedish School of Sport and Health Sciencest, Stockholm, Sweden. FAU - Monell, Elin AU - Monell E AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. AD - Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Servicest, Stockholm, Sweden. FAU - Frans, Emma M AU - Frans EM AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Barakat, Sarah AU - Barakat S AD - InsideOut Institute for Eating Disorders, The University of Sydney, Sydney, Australia. FAU - Pettie, Michaela A AU - Pettie MA AUID- ORCID: 0000-0001-5466-8848 AD - Department of Pathology and Biomedical Science, University of Otago Christchurch, Christchurch, New Zealand. FAU - Parker, Richard AU - Parker R AD - QIMR Berghofer Medical Research Institute, University of Queensland, Brisbane, Queensland, USA. FAU - Maguire, Sarah AU - Maguire S AUID- ORCID: 0000-0003-0754-9189 AD - InsideOut Institute for Eating Disorders, The University of Sydney, Sydney, Australia. FAU - Jordan, Jennifer AU - Jordan J AUID- ORCID: 0000-0003-4699-6301 AD - QIMR Berghofer Medical Research Institute, University of Queensland, Brisbane, Queensland, USA. AD - Specialist Mental Health Clinical Research Unit, Te Whatu Ora Waitaha Canterbury, Christchurch, New Zealand. FAU - Kennedy, Martin A AU - Kennedy MA AD - Department of Pathology and Biomedical Science, University of Otago Christchurch, Christchurch, New Zealand. FAU - Morancie, Nailah Adams AU - Morancie NA AD - Department of Family Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Bulik, Cynthia M AU - Bulik CM AUID- ORCID: 0000-0001-7772-3264 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. AD - Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. LA - eng SI - ClinicalTrials.gov/NCT04378101 GR - L30MH120619/MH/NIMH NIH HHS/United States GR - K01MH123914/MH/NIMH NIH HHS/United States GR - R56MH129437/MH/NIMH NIH HHS/United States GR - R01MH120170/MH/NIMH NIH HHS/United States GR - R01MH124871/MH/NIMH NIH HHS/United States GR - R01MH119084/MH/NIMH NIH HHS/United States GR - R01MH118278/MH/NIMH NIH HHS/United States GR - U01MH109528/MH/NIMH NIH HHS/United States GR - R276-2018-4581/Lundbeck Foundation/ GR - 538-2013-8864/Vetenskapsradet/ GR - PG-22-0478/Swedish Society for Medical Research/ GR - Swedish Mental Health Foundation/ GR - Fredrik och Ingrid Thurings Stiftelse/ GR - L30MH120619/MH/NIMH NIH HHS/United States GR - K01MH123914/MH/NIMH NIH HHS/United States GR - R56MH129437/MH/NIMH NIH HHS/United States GR - R01MH120170/MH/NIMH NIH HHS/United States GR - R01MH124871/MH/NIMH NIH HHS/United States GR - R01MH119084/MH/NIMH NIH HHS/United States GR - R01MH118278/MH/NIMH NIH HHS/United States GR - U01MH109528/MH/NIMH NIH HHS/United States PT - Journal Article PT - Validation Study DEP - 20260215 PL - England TA - Eur Eat Disord Rev JT - European eating disorders review : the journal of the Eating Disorders Association JID - 9436977 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - *Exercise/psychology MH - *Feeding and Eating Disorders/psychology/diagnosis MH - Reproducibility of Results MH - *Self Report/standards MH - Surveys and Questionnaires MH - Observational Studies as Topic MH - Multicenter Studies as Topic OTO - NOTNLM OT - compulsive exercise OT - cross-cultural validation OT - eating disorders OT - eating disorders genetics initiative OT - screening EDAT- 2026/02/16 06:30 MHDA- 2026/06/08 12:38 CRDT- 2026/02/16 00:54 PHST- 2026/01/03 00:00 [revised] PHST- 2025/11/24 00:00 [received] PHST- 2026/01/15 00:00 [accepted] PHST- 2026/06/08 12:38 [medline] PHST- 2026/02/16 06:30 [pubmed] PHST- 2026/02/16 00:54 [entrez] AID - 10.1002/erv.70084 [doi] PST - ppublish SO - Eur Eat Disord Rev. 2026 Jul;34(4):1003-1015. doi: 10.1002/erv.70084. Epub 2026 Feb 15. PMID- 41688959 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Feb 13 TI - Adaptation and validation of the neighbourhood environment walkability scale for German-speaking youth (NEWS-Y-G). LID - 10.1186/s12889-026-26590-3 [doi] LID - 709 AB - BACKGROUND: Adolescents' physical activity is related to characteristics of their neighbourhood environment. Understanding this relationship can help identify ways to promote this important health-related behaviour. The Neighbourhood Environment Walkability Scale for Youth (NEWS-Y) is the most prominent questionnaire to measure subjective perceptions on the neighbourhood environment that might have an influence on their physical activity. This study describes the development of the NEWS-Y for German-speaking adolescents (called NEWS-Y-G) and the evaluation of its reliability and validity. METHODS: The NEWS-Y-G was adapted and validated through a five-step process. First, the original NEWS-Y was translated into German using a back-translation technique. Participatory methods were then used to establish content validity by identifying environmental aspects specifically relevant to the German context. Third, ten cognitive interviews with adolescents were conducted for ensuring understandability before piloting the questionnaire with 587 adolescents. Of these, 249 participants completed the questionnaire twice, allowing for a test-retest reliability evaluation of subscales and individual items by using intraclass correlation coefficients (ICCs). Finally, construct validity was tested through correlations among subscales and associations with self-reported physical activity levels of participants. RESULTS: The NEWS-Y-G showed semantic equivalence with the original version. Five items were removed and twelve items were added, resulting in 74 items across the nine subscales: land use mix-diversity, recreational facilities, residential density, land use mix-access, street connectivity, walking/cycling facilities, aesthetics, traffic- and crime safety. The test-retest reliability of subscales (ICC range = 0.81-0.94) and individual items (ICC range = 0.32- 0.94) in the NEWS-Y-G was moderate to almost perfect. Moderate correlations were observed among several NEWS-Y-G subscales. Only two subscales - recreational facilities and aesthetics - showed statistically significant, albeit very weak, associations with self-reported physical activity (both rho = 0.13, p < 0.01), while no significant associations were found for the other seven subscales (rho = -0.08 to 0.03, p > 0.05). CONCLUSION: The NEWS-Y-G questionnaire demonstrated good test-retest reliability and provided preliminary evidence of validity. While this study supports its use in measuring subjective walkability among adolescents, further studies in German-speaking regions are needed to confirm its validity in relation to physical activity, accounting for different mobility types as well as gender and socioeconomic disparities. The NEWS-Y-G is a valuable tool for evaluating the neighbourhood environment's impact on adolescents, providing results that can inform urban planning and research to promote physical activity. FAU - Scheller, Daniel A AU - Scheller DA AD - TUM School of Medicine and Health, Department Health and Sport Sciences, Associate Professorship of Didactics in Sport and Health, Technical University of Munich, Georg-Brauchle-Ring 62, Munich, 80992, Germany. daniel.scheller@tum.de. FAU - Humpe, Andreas AU - Humpe A AD - Munich University of Applied Sciences, Schachenmeierstrasse 35, Munchen, 80636, Germany. FAU - Mess, Filip AU - Mess F AD - TUM School of Medicine and Health, Department Health and Sport Sciences, Associate Professorship of Didactics in Sport and Health, Technical University of Munich, Georg-Brauchle-Ring 62, Munich, 80992, Germany. FAU - Nogueira de Zorzi, Viviane AU - Nogueira de Zorzi V AD - Postgraduation Program in Physical Education, Federal University of Santa Catarina, Street Eng. Agronomico Andrei Cristian Ferreira, Trindade, Florianopolis, 88040-900, Brazil. FAU - Rech, Cassiano Ricardo AU - Rech CR AD - Postgraduation Program in Physical Education, Federal University of Santa Catarina, Street Eng. Agronomico Andrei Cristian Ferreira, Trindade, Florianopolis, 88040-900, Brazil. FAU - Bachner, Joachim AU - Bachner J AD - TUM School of Medicine and Health, Department Health and Sport Sciences, Associate Professorship of Didactics in Sport and Health, Technical University of Munich, Georg-Brauchle-Ring 62, Munich, 80992, Germany. LA - eng PT - Journal Article PT - Validation Study DEP - 20260213 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Adolescent MH - Female MH - *Walking/statistics & numerical data MH - Male MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Germany MH - *Environment Design MH - *Residence Characteristics/statistics & numerical data MH - *Neighborhood Characteristics/statistics & numerical data PMC - PMC12931025 OTO - NOTNLM OT - Adolescents OT - Environment OT - Neighbourhood OT - Perception OT - Physical activity OT - Questionnaire OT - Reliability OT - Urban planning OT - Validity OT - Walkability COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of the Technical University of Munich, Germany (reference number 77/22 S). Written informed consent was obtained from both a parent/legal guardian and the participant throughout all data collection phases (including both the interviews and questionnaires). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/14 05:30 MHDA- 2026/06/27 06:44 PMCR- 2026/02/13 CRDT- 2026/02/13 23:58 PHST- 2024/08/07 00:00 [received] PHST- 2026/02/04 00:00 [accepted] PHST- 2026/06/27 06:44 [medline] PHST- 2026/02/14 05:30 [pubmed] PHST- 2026/02/13 23:58 [entrez] PHST- 2026/02/13 00:00 [pmc-release] AID - 10.1186/s12889-026-26590-3 [pii] AID - 26590 [pii] AID - 10.1186/s12889-026-26590-3 [doi] PST - epublish SO - BMC Public Health. 2026 Feb 13;26(1):709. doi: 10.1186/s12889-026-26590-3. PMID- 41688664 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Feb 14 TI - Determinants of food choices on online food delivery applications among university students: a cross-sectional study. LID - 10.1038/s41598-026-40145-x [doi] LID - 9114 AB - The rapid expansion of online food delivery applications (OFDAs) has substantially influenced dietary behaviors among university students. This study examined factors associated with food choices, perceptions of healthy meals, and attitudes toward food safety among OFDAs users at King Khalid University. A cross-sectional survey was conducted among 397 students using a validated online questionnaire. Fast food was the most frequently ordered meal (72.0%), and price was the primary determinant of food choice. Male students were more likely than female students to select healthier options, and healthy food selection differed significantly by body mass index, with the highest proportion among students with obesity. Binary logistic regression showed that price (OR = 2.085), food appearance (OR = 1.487), and perceiving a healthy meal as containing a variety of vegetables (OR = 1.492) were significant predictors of healthy meal selection. Food safety perceptions were significantly associated with meal temperature and packaging, with meal temperature commonly reported as an indicator of food quality and safety. These findings suggest that food choices among OFDA users are associated with multiple factors and may inform efforts to improve the affordability, nutritional quality, visual appeal, and safety of meal options in digital food environments. FAU - Alshahry, Abduraheem Mohammad AU - Alshahry AM AD - Kidney Care Center, Aseer Health Cluster, Ministry of Health, Khamis Mushait, Saudi Arabia. FAU - Alhazmi, Amani AU - Alhazmi A AUID- ORCID: 0000-0002-4062-1640 AD - Public Health Department, Applied Medical Sciences College, King Khalid University, Abha, Saudi Arabia. Amanialhazmi@kku.edu.sa. LA - eng GR - RGP.1/150/46/Deanship of Scientific Research, King Khalid University/ PT - Journal Article DEP - 20260214 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Male MH - Female MH - Cross-Sectional Studies MH - *Students/psychology MH - Universities MH - *Food Preferences/psychology MH - Young Adult MH - *Choice Behavior MH - Surveys and Questionnaires MH - Adult MH - Adolescent MH - Food Safety MH - Fast Foods MH - Body Mass Index PMC - PMC12996546 OTO - NOTNLM OT - Body mass index OT - Diet OT - Food safety OT - Food services OT - Healthy OT - Students COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/02/14 05:31 MHDA- 2026/06/27 06:45 PMCR- 2026/02/14 CRDT- 2026/02/13 23:28 PHST- 2025/10/24 00:00 [received] PHST- 2026/02/10 00:00 [accepted] PHST- 2026/06/27 06:45 [medline] PHST- 2026/02/14 05:31 [pubmed] PHST- 2026/02/13 23:28 [entrez] PHST- 2026/02/14 00:00 [pmc-release] AID - 10.1038/s41598-026-40145-x [pii] AID - 40145 [pii] AID - 10.1038/s41598-026-40145-x [doi] PST - epublish SO - Sci Rep. 2026 Feb 14;16(1):9114. doi: 10.1038/s41598-026-40145-x. PMID- 41687326 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1873-6807 (Electronic) IS - 1740-1445 (Linking) VI - 56 DP - 2026 Mar TI - The Body Acceptance by Others Scale-2: An examination of its psychometric properties in a French-Canadian adult sample. PG - 102045 LID - S1740-1445(26)00016-1 [pii] LID - 10.1016/j.bodyim.2026.102045 [doi] AB - The 13-item Body Acceptance by Others Scale-2 (BAOS-2) is an instrument designed to measure generalised perceptions of body acceptance by others. Here, we examined the psychometric properties of a novel French translation of the BAOS-2. A total of 763 French-speaking adults from Canada were asked to complete the BAOS-2, alongside additional validated measures of positive body image, psychological well-being, and eating patterns. Exploratory factor analysis in a first split-half subsample (n = 382) indicated that a unidimensional model with all 13 items had good fit to the data. This model was cross-validated in a second split-half subsample (n = 381) using confirmatory factor analysis. A partial factors-only model indicated, as a function of subsamples, that the French BAOS-2 has differential item functioning based on respondent age, body mass index (BMI), and gender identity (men, women). In addition, higher respondent BMI was associated with lower body acceptance in both subsamples. Our results also supported convergent and concurrent validity of the French BAOS-2, with body acceptance by others associated with greater body appreciation and psychological well-being, as well as lower symptoms of maladaptive eating patterns. The present results indicate that the French BAOS-2 has strong psychometric properties in French-speaking Canadian adults. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Maiano, Christophe AU - Maiano C AD - Cyberpsychology Laboratory and Department of Psychoeducation and Psychology, Universite du Quebec en Outaouais (UQO|Campus de Saint-Jerome), Saint-Jerome, Canada; Substantive-Methodological Synergy Research Laboratory, Department of Psychology, Concordia University, Montreal, Canada. Electronic address: christophe.maiano@uqo.ca. FAU - Swami, Viren AU - Swami V AD - School of Psychology, Sport, and Sensory Sciences, Anglia Ruskin University, Cambridge, United Kingdom; Centre for Psychological Medicine, Perdana University, Kuala Lumpur, Malaysia. FAU - Tylka, Tracy L AU - Tylka TL AD - Department of Psychology, The Ohio State University, Columbus, OH, USA. FAU - Aime, Annie AU - Aime A AD - Cyberpsychology Laboratory and Department of Psychoeducation and Psychology, Universite du Quebec en Outaouais (UQO|Campus de Saint-Jerome), Saint-Jerome, Canada. LA - eng PT - Journal Article DEP - 20260212 PL - Netherlands TA - Body Image JT - Body image JID - 101222431 SB - IM MH - Humans MH - Female MH - Psychometrics MH - Male MH - Adult MH - *Body Image/psychology MH - Canada MH - Reproducibility of Results MH - Body Satisfaction MH - Body Mass Index MH - Middle Aged MH - Young Adult MH - Surveys and Questionnaires/standards MH - Psychological Well-Being MH - Adolescent OTO - NOTNLM OT - Body acceptance by others OT - Canada OT - French OT - Positive body image OT - Psychometrics OT - Test adaptation COIS- Declaration of competing interest The authors declare they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper . Given her role as Editor-in-Chief of Body Image, Tracy L. Tylka had no involvement in the peer review of this article and had no access to information regarding its peer review. Full responsibility for the editorial process for this article was delegated to another journal editor. EDAT- 2026/02/14 05:30 MHDA- 2026/03/06 09:11 CRDT- 2026/02/13 18:06 PHST- 2025/09/26 00:00 [received] PHST- 2026/01/16 00:00 [revised] PHST- 2026/02/06 00:00 [accepted] PHST- 2026/03/06 09:11 [medline] PHST- 2026/02/14 05:30 [pubmed] PHST- 2026/02/13 18:06 [entrez] AID - S1740-1445(26)00016-1 [pii] AID - 10.1016/j.bodyim.2026.102045 [doi] PST - ppublish SO - Body Image. 2026 Mar;56:102045. doi: 10.1016/j.bodyim.2026.102045. Epub 2026 Feb 12. PMID- 41685224 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260213 LR - 20260215 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Mechanisms through which table tennis practice influences the development of big five personality traits in primary school students. PG - 1705050 LID - 10.3389/fpsyg.2026.1705050 [doi] LID - 1705050 AB - This quasi-experimental study examined the effects of a 16-week systematic table tennis training program on the Big Five personality traits of primary school students. Previous research has largely focused on the macro-level effects of physical activity, with limited fine-grained investigation into the psychological shaping mechanisms of specific sports, particularly intervention-based evidence involving children without prior training. A total of 98 male students aged 9-10 years were enrolled and, after propensity score matching (including age, baseline personality scores, etc.), were allocated to an experimental group (n = 49) or a control group (n = 49). The experimental group received moderate-intensity table tennis training three times per week (120 min per session), comprising technical drills, tactical exercises, and match simulations, while the control group maintained their routine activities. The short-form NEO Five-Factor Inventory (NEO-FFI) was administered before and after the intervention. A 2 x 2 mixed-design ANOVA and analysis of covariance (ANCOVA), with pretest scores as covariates, were used to analyze the effects. The results revealed significant Time x Group interaction effects for Openness (F(1,92) = 64.32, p < 0.001, eta (2) = 0.411), Neuroticism (F(1,92) = 42.18, p < 0.001, eta (2) = 0.314), Agreeableness (F(1,92) = 89.45, p < 0.001, eta (2) = 0.493), and Extraversion (F(1,92) = 56.74, p < 0.001, eta (2) = 0.381) but not for Conscientiousness (p = 0.076). Simple effects analyses indicated that the experimental group showed significant post-intervention improvements in Openness (d = 1.67), Agreeableness (d = 1.56), and Extraversion (d = 0.86), along with a significant reduction in Neuroticism (d = -0.89). No significant changes were observed in the control group. The findings suggest that systematic table tennis training can effectively promote the development of emotional stability, openness, agreeableness, and extraversion in primary school students, but it has a limited effect on conscientiousness. This study provides preliminary causal evidence for fostering children's personality development through a specific sport and offers empirical support for the integration of sports and education. Limitations include the all-male sample and the quasi-experimental design. Future research should employ large-scale randomized controlled trials and multi-source assessments to further validate these results. CI - Copyright (c) 2026 Wang, Zou, Du, Chen and Huang. FAU - Wang, Jian AU - Wang J AD - School of Physical Education and Health, East China Jiaotong University, Nanchang, China. FAU - Zou, Yating AU - Zou Y AD - College of Education, Nanchang Vocational University, Nanchang, China. FAU - Du, Liping AU - Du L AD - School of Physical Education, Xichang University, Xichang, China. FAU - Chen, Yang AU - Chen Y AD - School of Physical Education, Xi'an Jiaotong University, Xi'an, China. FAU - Huang, Guoyuan AU - Huang G AD - College of Physical Education, Sichuan Agricultural University, Ya'an, China. LA - eng PT - Journal Article DEP - 20260128 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC12892341 OTO - NOTNLM OT - big five personality traits OT - exercise intervention OT - primary school students OT - psychology OT - table tennis COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/13 06:33 MHDA- 2026/02/13 06:34 PMCR- 2026/01/28 CRDT- 2026/02/13 04:33 PHST- 2025/09/14 00:00 [received] PHST- 2025/12/30 00:00 [revised] PHST- 2026/01/12 00:00 [accepted] PHST- 2026/02/13 06:34 [medline] PHST- 2026/02/13 06:33 [pubmed] PHST- 2026/02/13 04:33 [entrez] PHST- 2026/01/28 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1705050 [doi] PST - epublish SO - Front Psychol. 2026 Jan 28;17:1705050. doi: 10.3389/fpsyg.2026.1705050. eCollection 2026. PMID- 41685214 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260213 LR - 20260215 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Green exercise and kinesiophobia among Chinese adolescents: the mediating role of self-efficacy. PG - 1743182 LID - 10.3389/fpsyg.2026.1743182 [doi] LID - 1743182 AB - OBJECTIVE: Kinesiophobia is a common psychological barrier to physical activity during adolescence and is characterized by fear-related attention to bodily sensations and avoidance of movement. This study examined whether green exercise is associated with lower kinesiophobia among adolescents and whether self-efficacy statistically mediates these associations, drawing on social cognitive theory. METHODS: A cross-sectional questionnaire survey was conducted among 1,099 Chinese students in Grades 5-9 (aged 10-15 years); adolescents. Participants completed validated self-report measures of green exercise (5 items), self-efficacy (10 items), and kinesiophobia (13 items; somatic focus and activity avoidance). Descriptive statistics, multiple regression (controlling for gender, grade, and place of residence), structural equation modeling (SEM), and bias-corrected bootstrap tests (5,000 resamples) were used to evaluate the hypothesized relationships. RESULTS: In multiple regression analyses, green exercise (beta = -0.217; beta = -0.289) and self-efficacy (beta = -0.279; beta = -0.266) were significant negative predictors of somatic focus and activity avoidance, respectively (all p < 0.001), with modest explained variance (R (2) = 0.194 and 0.232). In SEM, green exercise was positively associated with self-efficacy (beta = 0.351, p < 0.001) and showed significant direct associations with somatic focus (beta = -0.251, p < 0.001) and activity avoidance (beta = -0.315, p < 0.001). Self-efficacy was negatively associated with somatic focus (beta = -0.308, p < 0.001) and activity avoidance (beta = -0.299, p < 0.001). Bootstrap analyses supported partial indirect effects via self-efficacy for somatic focus (beta = -0.108; 30.08% of total effect) and activity avoidance (beta = -0.105; 25.00% of total effect). CONCLUSION: Findings indicate that greater participation in green exercise is associated with lower kinesiophobia in adolescents, partly through higher self-efficacy. The pattern is consistent with a social-cognitive mechanism linking outdoor physical activity to fear-related responses to movement, while causal inferences require longitudinal or experimental research. CI - Copyright (c) 2026 Kong, Ren, Liu and Yin. FAU - Kong, Mingmin AU - Kong M AD - School of Sports Training, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Ren, Yawei AU - Ren Y AD - School of Sports Training, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Liu, Tong AU - Liu T AD - School of Sports Training, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Yin, Zhonggen AU - Yin Z AD - College of Physical Education and Health Management, Chongqing University of Education, Chongqing, China. LA - eng PT - Journal Article DEP - 20260128 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC12891208 OTO - NOTNLM OT - activity avoidance OT - adolescents OT - green exercise OT - kinesiophobia OT - self-efficacy OT - social cognitive theory OT - somatic focus COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/13 06:32 MHDA- 2026/02/13 06:33 PMCR- 2026/01/28 CRDT- 2026/02/13 04:33 PHST- 2025/11/10 00:00 [received] PHST- 2025/12/23 00:00 [revised] PHST- 2026/01/09 00:00 [accepted] PHST- 2026/02/13 06:33 [medline] PHST- 2026/02/13 06:32 [pubmed] PHST- 2026/02/13 04:33 [entrez] PHST- 2026/01/28 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1743182 [doi] PST - epublish SO - Front Psychol. 2026 Jan 28;17:1743182. doi: 10.3389/fpsyg.2026.1743182. eCollection 2026. PMID- 41685062 OWN - NLM STAT- Publisher LR - 20260920 IS - 1520-9210 (Print) IS - 1941-0077 (Electronic) IS - 1520-9210 (Linking) DP - 2026 Feb 10 TI - Screen Detection from Egocentric Image Streams Leveraging Multi-View Vision Language Model. LID - 10.1109/tmm.2026.3660180 [doi] AB - Accurately monitoring the screen exposure of young children is important for research related to screen use, such as childhood obesity, physical activity, and social interaction. Most existing studies rely upon self-report or manual measures from bulky wearable sensors, thus lacking efficiency and accuracy in capturing quantitative screen exposure data. In this work, we developed a novel screen detection framework that utilizes egocentric images from a wearable sensor, named the screen time tracker (STT), and a vision language model (VLM). In particular, we devised a multi-view VLM that takes multiple views from egocentric image streams and interprets screen exposure dynamically. We validated our approach by using a dataset of children's free-living activities, demonstrating significant improvement over existing methods in conventional vision language models and object detection models. The combination of a vision language model and a lightweight hardware design provides a novel solution in screen detection for children. The proposed framework has great potential to benefit children's behavioral study. The code is available at https://github.com/YGanLab/MV-VLM. FAU - Li, Xueshen AU - Li X AD - Department of Biomedical Engineering, Stevens Institute of Technology. FAU - Shen, Sen AU - Shen S AD - Department of Computer Science, Iowa State University. FAU - Hou, Xinlong AU - Hou X AD - Department of Biomedical Engineering, Stevens Institute of Technology. FAU - Gao, Xinran AU - Gao X AD - Department of Biomedical Engineering, Stevens Institute of Technology. FAU - Huang, Ziyi AU - Huang Z AD - School of Biological and Health Systems Engineering, Arizona State University. FAU - Holiday, Steven J AU - Holiday SJ AD - Department of Communication & Information Science, University of Alabama. FAU - Cribbet, Matthew R AU - Cribbet MR AD - Department of Psychology, University of Alabama. FAU - White, Susan W AU - White SW AD - Department of Psychology, University of Alabama. FAU - Sazonov, Edward AU - Sazonov E AD - Department of Electrical and Computer Engineering, University of Alabama. FAU - Gan, Yu AU - Gan Y AD - Department of Biomedical Engineering, Stevens Institute of Technology. LA - eng GR - R21 HD104164/HD/NICHD NIH HHS/United States GR - R21 HD112773/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20260210 PL - United States TA - IEEE Trans Multimedia JT - IEEE transactions on multimedia JID - 101210915 PMC - PMC12893618 MID - NIHMS2123918 OTO - NOTNLM OT - Egocentric Image Streams OT - Vision Language Model OT - Wearable Sensor EDAT- 2026/02/13 06:32 MHDA- 2026/02/13 06:32 PMCR- 2026/02/12 CRDT- 2026/02/13 04:31 PHST- 2026/02/13 06:32 [medline] PHST- 2026/02/13 06:32 [pubmed] PHST- 2026/02/13 04:31 [entrez] PHST- 2026/02/12 00:00 [pmc-release] AID - 10.1109/tmm.2026.3660180 [doi] PST - aheadofprint SO - IEEE Trans Multimedia. 2026 Feb 10:10.1109/tmm.2026.3660180. doi: 10.1109/tmm.2026.3660180. PMID- 41684797 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260213 LR - 20260215 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Latent profiles of post-traumatic distress and growth in adolescents: the role of modifiable protective factors. PG - 1720487 LID - 10.3389/fpsyt.2026.1720487 [doi] LID - 1720487 AB - OBJECTIVE: This study examined heterogeneous patterns of trauma-related adaptation among Chinese adolescents during the post-COVID-19 recovery phase, focusing on the co-occurrence of posttraumatic distress (PTD) and posttraumatic growth (PTG). We also investigated how modifiable psychosocial protective and vulnerability factors were associated with membership in different adaptation profiles. METHOD: A large-scale cross-sectional survey was administered to 5, 044 students (aged 9-17 years; 46.6% male) from 15 primary and secondary schools in Wuhan, China. Validated instruments assessed posttraumatic stress symptoms (PCL-C), posttraumatic growth (PTGI), depressive symptoms (CES-D), and anxiety (SAS). Protective and vulnerability factors included resilience (CD-RISC), perceived social support (SSRS), physical activity (PARS-3), school belonging (PSSM), adaptive coping (SCSQ), and trait anxiety (TAI). Latent profile analysis (LPA) was used to identify adaptation profiles, and multinomial logistic regression examined how modifiable psychosocial factors were associated with profile membership. RESULTS: LPA revealed four empirically derived profiles: a High Distress/High Growth-Moderate PTSD profile (76.9%), a Low Distress-High Growth profile (4.8%), a Low Growth-Moderate Distress profile (3.9%), and a High Distress/High Growth-High PTSD profile (14.4%). The vast majority of adolescents showed some degree of both PTD and PTG, consistent with dual-process perspectives. In multinomial models, higher resilience, social support, school belonging, adaptive coping, and physical activity were associated with greater likelihood of belonging to the Low Distress-High Growth profile rather than more distressed profiles, whereas higher trait anxiety was associated with increased odds of membership in profiles characterized by greater distress. CONCLUSIONS: In this large school-based sample of Chinese adolescents, distress and growth frequently co-occurred and clustered into distinct adaptation profiles that differed systematically in psychosocial resources. Resilience, social connectedness, school belonging, and physical activity emerged as promising targets for trauma-informed, school-based support, whereas trait anxiety appeared to mark heightened vulnerability. Given the cross-sectional and single-region design, these findings should be interpreted as exploratory, and longitudinal and cross-cultural studies are needed to clarify temporal and contextual influences on adolescent trauma adaptation. CI - Copyright (c) 2026 Yang, Sun and Zhang. FAU - Yang, Haiying AU - Yang H AD - School of Physical Education, Southwest Jiaotong University, Chengdu, China. FAU - Sun, Lihong AU - Sun L AD - School of Physical Education, Hubei Second Normal University, Wuhan, China. FAU - Zhang, Ying AU - Zhang Y AD - School of Education, Hubei Second Normal University, Wuhan, China. LA - eng PT - Journal Article DEP - 20260128 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC12891221 OTO - NOTNLM OT - COVID-19 OT - adolescents OT - latent profile analysis OT - posttraumatic distress OT - posttraumatic growth COIS- The authors declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/13 06:32 MHDA- 2026/02/13 06:33 PMCR- 2026/01/28 CRDT- 2026/02/13 04:28 PHST- 2025/10/08 00:00 [received] PHST- 2026/01/03 00:00 [revised] PHST- 2026/01/05 00:00 [accepted] PHST- 2026/02/13 06:33 [medline] PHST- 2026/02/13 06:32 [pubmed] PHST- 2026/02/13 04:28 [entrez] PHST- 2026/01/28 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1720487 [doi] PST - epublish SO - Front Psychiatry. 2026 Jan 28;17:1720487. doi: 10.3389/fpsyt.2026.1720487. eCollection 2026. PMID- 41683368 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 3 DP - 2026 Feb 6 TI - Dietary and Lifestyle Factors Associated with Self-Esteem in Adolescents: An Exploratory Questionnaire-Based Study. LID - 10.3390/nu18030546 [doi] LID - 546 AB - BACKGROUND: Self-esteem plays a central role in adolescent psychological health and may be shaped by everyday health behaviors such as eating patterns and engagement in physical activity. However, evidence from Eastern European youth remains comparatively limited. Lower levels of self-worth during adolescence have been linked to increased vulnerability to maladaptive behaviors, including substance use. The present study aimed to explore preliminary associations between lifestyle behaviors, nutritional practices, and self-esteem in a sample of Romanian adolescents. METHODS: A cross-sectional design was used, involving 113 participants aged 14-18 years. Self-esteem was assessed using the Rosenberg Self-Esteem Scale, while lifestyle behaviors were evaluated through a standardized questionnaire. Body mass index was calculated based on self-reported height and weight. Statistical analyses included Pearson correlation coefficients and multiple linear regression models. RESULTS: Higher self-esteem scores were strongly associated with greater participation in physical activity and adherence to a balanced diet, while inverse relationships were observed with unhealthy dietary habits and higher BMI values. Physical activity emerged as the most influential predictor of self-esteem, accounting for over three-quarters of the variance in Rosenberg scale scores. CONCLUSIONS: In this preliminary analysis, physical activity and healthier dietary behaviors were associated with higher self-esteem scores among adolescents. Given the exploratory nature of the study, these findings should be interpreted with caution. They primarily serve to generate hypotheses and highlight the need for future studies with validated instruments, larger samples, and appropriate control for potential confounding factors to better elucidate the relationship between lifestyle behaviors and adolescent self-esteem. FAU - Salcudean, Andreea AU - Salcudean A AD - Department of Bioethics, Deontology and Medical Communication, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania. FAU - Osz, Bianca-Eugenia AU - Osz BE AD - Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania. FAU - Cimpian, Dora-Mihaela AU - Cimpian DM AUID- ORCID: 0009-0005-0113-6748 AD - Department of Bioethics, Deontology and Medical Communication, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania. FAU - Popovici, Ramona-Amina AU - Popovici RA AUID- ORCID: 0000-0002-3852-9060 AD - Department of Management and Communication in Dental Medicine, Department I, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania. FAU - Bodo, Cristina-Raluca AU - Bodo CR AD - Department of Bioethics, Deontology and Medical Communication, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania. FAU - Torok, Sarolta AU - Torok S AD - Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania. FAU - Corodan-Comiati, Diana-Mihaela AU - Corodan-Comiati DM AD - Psychiatry Clinic 1, County Clinical Hospital Mures, 540142 Targu Mures, Romania. FAU - Dumache, Raluca AU - Dumache R AUID- ORCID: 0000-0003-1790-8130 AD - Department of Forensic Medicine, Bioethics, Medical Ethics and Medical Law, Victor Babes University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania. FAU - Kis, Andreea-Mihaela AU - Kis AM AUID- ORCID: 0009-0004-4581-8487 AD - Department of Management and Communication in Dental Medicine, Department I, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania. FAU - Cincu, Madalina-Gabriela AU - Cincu MG AD - Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania. FAU - Grebenisan, Lorena-Mihaela AU - Grebenisan LM AUID- ORCID: 0000-0003-1745-9427 AD - Department of Psychiatry, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania. FAU - Strete, Elena-Gabriela AU - Strete EG AUID- ORCID: 0000-0003-2963-6793 AD - Department of Psychiatry, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania. LA - eng GR - 163/6/10.01.2023/George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures/ PT - Journal Article DEP - 20260206 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - *Self Concept MH - Female MH - Male MH - Cross-Sectional Studies MH - *Life Style MH - Surveys and Questionnaires MH - Body Mass Index MH - Exercise/psychology MH - *Adolescent Behavior/psychology MH - *Feeding Behavior/psychology MH - Romania MH - *Diet/psychology MH - Health Behavior PMC - PMC12899637 OTO - NOTNLM OT - BMI OT - adolescents OT - lifestyle OT - nutrition OT - physical activity OT - self-esteem COIS- The authors declare no conflicts of interest. EDAT- 2026/02/13 06:33 MHDA- 2026/02/13 06:34 PMCR- 2026/02/06 CRDT- 2026/02/13 01:08 PHST- 2026/01/12 00:00 [received] PHST- 2026/01/28 00:00 [revised] PHST- 2026/02/04 00:00 [accepted] PHST- 2026/02/13 06:34 [medline] PHST- 2026/02/13 06:33 [pubmed] PHST- 2026/02/13 01:08 [entrez] PHST- 2026/02/06 00:00 [pmc-release] AID - nu18030546 [pii] AID - nutrients-18-00546 [pii] AID - 10.3390/nu18030546 [doi] PST - epublish SO - Nutrients. 2026 Feb 6;18(3):546. doi: 10.3390/nu18030546. PMID- 41683338 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 3 DP - 2026 Feb 3 TI - The Impact of Physical Activity and Nutritional Patterns on Phase Angle in Healthy Adolescents. LID - 10.3390/nu18030516 [doi] LID - 516 AB - BACKGROUND: Phase angle (PhA), derived from bioelectrical impedance analysis (BIA), is a non-invasive parameter that reflects cellular integrity and nutritional status. Although PhA is increasingly used in pediatric settings, evidence on modifiable determinants in healthy adolescents remains limited. METHODS: This study was conducted in 56 adolescents (median age 16 years) who underwent BIA measurement including PhA at 50 kHz. Lifestyle and diet were assessed using the validated questionnaire and included physical activity level (school and free time), sleep length, and diet quality indices together with selected food intake frequencies. RESULTS: The median PhA was 5.16 degrees (IQR 4.88-5.46). In multivariable models, male sex (B = 0.96, p < 0.001) and higher free-time physical activity were independently associated with higher PhA, with graded effects for moderate (B = 0.42, p = 0.004) and high activity (B = 0.55, p = 0.001) versus low. Dietary indices and individual food items did not retain significance after adjustment. Penalized logistic models confirmed lower odds of low PhA with moderate (OR: 0.13, 95% CI: -3.66 to -0.56) and high (OR: 0.01, 95% CI: -9.15 to -1.87) versus low free-time activity. CONCLUSIONS: In healthy adolescents, habitual free-time physical activity is the main factor of PhA. These findings support the promotion of physical activity in youth as a modifiable determinant of cellular health. FAU - Przytula, Agata AU - Przytula A AUID- ORCID: 0009-0006-3818-8960 AD - Department of Clinical Dietetics, Medical University of Lublin, ul. Chodzki 7, 20-063 Lublin, Poland. FAU - Glibowski, Pawel AU - Glibowski P AUID- ORCID: 0000-0003-1774-6899 AD - Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, 8 Skromna Str., 20-704 Lublin, Poland. FAU - Popiolek-Kalisz, Joanna AU - Popiolek-Kalisz J AUID- ORCID: 0000-0001-9108-8391 AD - Department of Clinical Dietetics, Medical University of Lublin, ul. Chodzki 7, 20-063 Lublin, Poland. LA - eng PT - Journal Article DEP - 20260203 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Adolescent MH - Female MH - *Exercise/physiology MH - *Nutritional Status MH - *Electric Impedance MH - Life Style MH - *Diet MH - *Body Composition MH - *Feeding Behavior MH - Surveys and Questionnaires PMC - PMC12899008 OTO - NOTNLM OT - bioelectrical impedance analysis OT - body composition OT - children OT - malnutrition OT - phase angle OT - physical activity COIS- The authors declare no conflicts of interest. EDAT- 2026/02/13 06:32 MHDA- 2026/02/13 06:33 PMCR- 2026/02/03 CRDT- 2026/02/13 01:08 PHST- 2026/01/15 00:00 [received] PHST- 2026/01/28 00:00 [revised] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/02/13 06:33 [medline] PHST- 2026/02/13 06:32 [pubmed] PHST- 2026/02/13 01:08 [entrez] PHST- 2026/02/03 00:00 [pmc-release] AID - nu18030516 [pii] AID - nutrients-18-00516 [pii] AID - 10.3390/nu18030516 [doi] PST - epublish SO - Nutrients. 2026 Feb 3;18(3):516. doi: 10.3390/nu18030516. PMID- 41683334 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260729 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 3 DP - 2026 Feb 2 TI - Nutritional Status and Dietary Intakes of a Community of Rural Women in Barcena Villa Nueva, Guatemala: A Small-Scale Observational Study. LID - 10.3390/nu18030512 [doi] LID - 512 AB - Background/Objectives: Rural communities in Guatemala face a growing double-burden of malnutrition. Women of reproductive age are a key population to address, as their health and nutritional status influence not only their own well-being but also that of their children and families. However, they often experience greater exposure to nutritional risks due to gendered inequalities in access to resources, education, and health care. This small-scale observational study aimed to describe the dietary habits and nutritional status of a sub-group of women living in a rural area of Barcena Villa Nueva, Guatemala. Methods: An observational study was conducted between March and April 2025 among women aged >/=18 years from two rural communities. Dietary data were collected through structured interviews, 24 h dietary recall (24-hR), and a validated food frequency questionnaire (FFQ). Anthropometric and biochemical measurements were also collected. Results: A total of 22 women were included (mean age: 41.3 +/- 16.3 years). The prevalence of obesity and central obesity was 45.5% and 86.0%, respectively. Quantitative dietary assessment based on the 24 h recall showed a mean energy intake approximately 35% higher than the recommended values, with a high contribution from fats and carbohydrates and an excessive sodium intake. In contrast, intakes of potassium, zinc, and folic acid were below the recommended levels. The qualitative analysis of the food frequency questionnaire indicated a dietary pattern characterized by high consumption of carbohydrates, animal-based protein sources, traditional energy-dense foods, and ultra-processed products, alongside a limited intake of vegetables and fruits. Datary diversity was low (4.9, SD: 1.1). Conclusions: This small-scale observational scale study provides a preliminary overview of dietary patterns and nutritional status among women living in a rural community in Guatemala. Although the findings are not generalizable, they suggest the coexistence of excessive energy intake, suboptimal micronutrient intake, and low dietary diversity. These results underscore the need for further research using larger and more representative samples and may help inform the development of context-specific nutrition education initiatives in similar underserved settings. FAU - Basilico, Sara AU - Basilico S AUID- ORCID: 0000-0001-6860-6429 AD - Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Sofroniou, Angeliki AU - Sofroniou A AUID- ORCID: 0000-0001-9862-5719 AD - Department of Food and Drug, University of Parma, 43121 Parma, Italy. FAU - Conti, Maria Vittoria AU - Conti MV AUID- ORCID: 0000-0002-8120-7091 AD - Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Dieguez, Paola AU - Dieguez P AD - The Missionary Sisters of the Sacred Heart of Jesus, Cabrini Foundation, Zone 6, Guatemala City 01006, Guatemala. FAU - Cena, Hellas AU - Cena H AUID- ORCID: 0000-0002-5752-6199 AD - Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. AD - Clinical Nutrition Unit, Istituti Clinici Scientifici Maugeri, Istituto di Ricovero e Cura a Carattere Scientifico, 27100 Pavia, Italy. AD - Italian Institute for Planetary Health, 00168 Rome, Italy. LA - eng GR - PE00000003/This research was funded under the National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment 1.3 - Call for tender No. 341 of 15 March 2022 of Italian Ministry of University and Research funded by the European Union - NextGenerationEU/ PT - Journal Article PT - Observational Study DEP - 20260202 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Guatemala/epidemiology MH - Adult MH - *Nutritional Status MH - Middle Aged MH - *Rural Population/statistics & numerical data MH - *Diet/statistics & numerical data MH - Energy Intake MH - *Feeding Behavior MH - Young Adult MH - Nutrition Assessment MH - Adolescent MH - Obesity/epidemiology MH - Diet Surveys MH - Prevalence PMC - PMC12899360 OTO - NOTNLM OT - developing countries OT - dietary diversity OT - malnutrition double-burden OT - nutrition OT - obesity OT - women COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. The Cabrini Foundation had no role in the design of the study; in the collection, analysis, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/02/13 06:33 MHDA- 2026/02/13 06:34 PMCR- 2026/02/02 CRDT- 2026/02/13 01:08 PHST- 2025/11/19 00:00 [received] PHST- 2026/01/29 00:00 [revised] PHST- 2026/02/02 00:00 [accepted] PHST- 2026/02/13 06:34 [medline] PHST- 2026/02/13 06:33 [pubmed] PHST- 2026/02/13 01:08 [entrez] PHST- 2026/02/02 00:00 [pmc-release] AID - nu18030512 [pii] AID - nutrients-18-00512 [pii] AID - 10.3390/nu18030512 [doi] PST - epublish SO - Nutrients. 2026 Feb 2;18(3):512. doi: 10.3390/nu18030512. PMID- 41683332 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 3 DP - 2026 Feb 2 TI - Dietary Diversity, Dietary Patterns, and Cardiometabolic Health in University Students: A Cross-Sectional Study. LID - 10.3390/nu18030511 [doi] LID - 511 AB - Background: Cardiometabolic risk is increasingly observed in young adults, particularly during university years, and is not limited to individuals with elevated body mass index. Emerging evidence highlights the presence of normal weight obesity-characterized by excess adiposity and unfavorable body composition despite normal BMI-which may confer early metabolic vulnerability. Dietary diversity is often promoted as a marker of dietary adequacy; however, its relationship with adiposity, body composition, and muscular health remains inconsistent, particularly in Latin American populations. Moreover, few studies have directly contrasted dietary diversity indicators with empirically derived dietary patterns in relation to cardiometabolic and functional outcomes. Objective: To examine the associations between dietary diversity, dietary patterns, and indicators of adiposity, muscular strength, and relative muscle mass in Ecuadorian university students. Methods: A cross-sectional study was conducted among 349 undergraduate students aged 18-26 years enrolled in health sciences programs in Ecuador. Dietary intake was assessed using a validated food frequency questionnaire. Dietary diversity was quantified using the Food and Agriculture Organization's Individual Dietary Diversity Score, while dietary patterns were identified through principal component analysis followed by k-means clustering. Outcomes included excess body weight, relative muscle mass assessed by bioelectrical impedance analysis, and handgrip strength. Multivariable Poisson and linear regression models were fitted, adjusting for age, sex, academic program, physical activity level, and pre-existing conditions. Results: Despite their young age and low prevalence of diagnosed disease, approximately one-third of the participants exhibited markers of early cardiometabolic risk, including excess body weight and central adiposity. Higher dietary diversity was independently associated with a higher prevalence of excess body weight (adjusted prevalence ratio per one-unit increase in IDDS: 1.17; 95% CI: 1.06-1.30) and with greater relative muscle mass (adjusted beta = 0.13; 95% CI: 0.05-0.22), whereas no association was observed with handgrip strength. In contrast, dietary patterns derived from multivariate analysis showed no significant associations with adiposity, muscular strength, or relative muscle mass after adjustment. Conclusions: In this young adult population, dietary diversity captured aspects of overall dietary exposure associated with both increased adiposity and greater lean mass, but not with muscular strength. Empirically derived dietary patterns demonstrated limited discriminatory capacity, likely reflecting dietary homogeneity within the cohort. These findings indicate that dietary diversity alone does not necessarily reflect diet quality and underscore the importance of interpreting diversity metrics alongside indicators of food quality, energy density, and body composition when evaluating early cardiometabolic risk in contemporary food environments. FAU - Fonseca-Perez, Diana AU - Fonseca-Perez D AUID- ORCID: 0000-0002-6437-2730 AD - Carrera de Nutricion y Dietetica, Facultad de Ciencias de la Salud, Universidad Catolica de Santiago de Guayaquil, Guayaquil 090615, Ecuador. FAU - Alvarez-Cordova, Ludwig AU - Alvarez-Cordova L AUID- ORCID: 0000-0002-6116-6122 AD - Maestria de Nutricion y Dietetica, Facultad de Ciencias de la Salud, Universidad de Las Americas (UDLA), Quito 170503, Ecuador. FAU - Arteaga-Pazmino, Cecilia AU - Arteaga-Pazmino C AUID- ORCID: 0000-0003-2472-3820 AD - Carrera de Nutricion y Dietetica, Facultad de Ciencias Medicas, Universidad de Guayaquil, Guayaquil 090615, Ecuador. FAU - Sierra-Nieto, Victor AU - Sierra-Nieto V AUID- ORCID: 0000-0002-0052-9209 AD - Carrera de Fisioterapia, Facultad de Ciencias de la Salud, Universidad Catolica de Santiago de Guayaquil, Guayaquil 090615, Ecuador. FAU - Cagua-Ordonez, Jaen AU - Cagua-Ordonez J AUID- ORCID: 0000-0002-1684-5206 AD - Facultad de Ciencias de la Salud y Bienestar Humano, Universidad Tecnologica Indoamerica, Quito 170103, Ecuador. FAU - Frias-Toral, Evelyn AU - Frias-Toral E AUID- ORCID: 0000-0002-2228-0141 AD - Escuela de Medicina, Universidad Espiritu Santo, Samborondon 0901952, Ecuador. AD - Division of Research, Texas State University, 601 University Dr., San Marcos, TX 78666, USA. FAU - Muscogiuri, Giovanna AU - Muscogiuri G AUID- ORCID: 0000-0002-8809-4931 AD - Endocrinology Unit, Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy. AD - Italian Centre for the Care and Wellbeing of Patients with Obesity, Federico II University Hospital, 80131 Naples, Italy. AD - UNESCO Chair on Health Education and Sustainable Development, Federico II University, 80131 Naples, Italy. FAU - Reytor-Gonzalez, Claudia AU - Reytor-Gonzalez C AUID- ORCID: 0009-0007-4234-5524 AD - Facultad de Ciencias de la Salud y Bienestar Humano, Universidad Tecnologica Indoamerica, Ambato 180150, Ecuador. FAU - Simancas-Racines, Daniel AU - Simancas-Racines D AUID- ORCID: 0000-0002-3641-1501 AD - Facultad de Ciencias de la Salud y Bienestar Humano, Universidad Tecnologica Indoamerica, Ambato 180150, Ecuador. LA - eng PT - Journal Article DEP - 20260202 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Female MH - Young Adult MH - Adult MH - Universities MH - Adolescent MH - *Students/statistics & numerical data MH - *Diet MH - Adiposity MH - Body Composition MH - Ecuador/epidemiology MH - Body Mass Index MH - *Feeding Behavior MH - Hand Strength PMC - PMC12899775 OTO - NOTNLM OT - Latin America OT - body composition OT - cardiometabolic risk OT - dietary diversity OT - dietary patterns OT - muscle mass OT - university students OT - young adults COIS- The authors declare that they have no commercial or financial relationships that could be construed as potential conflicts of interest. EDAT- 2026/02/13 06:33 MHDA- 2026/02/13 06:34 PMCR- 2026/02/02 CRDT- 2026/02/13 01:08 PHST- 2025/12/26 00:00 [received] PHST- 2026/01/28 00:00 [revised] PHST- 2026/01/29 00:00 [accepted] PHST- 2026/02/13 06:34 [medline] PHST- 2026/02/13 06:33 [pubmed] PHST- 2026/02/13 01:08 [entrez] PHST- 2026/02/02 00:00 [pmc-release] AID - nu18030511 [pii] AID - nutrients-18-00511 [pii] AID - 10.3390/nu18030511 [doi] PST - epublish SO - Nutrients. 2026 Feb 2;18(3):511. doi: 10.3390/nu18030511. PMID- 41683282 OWN - NLM STAT- MEDLINE DCOM- 20260721 LR - 20260721 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 3 DP - 2026 Jan 30 TI - Predictors and Risk Scoring of Postnatal Growth Failure in Very-Low-Birth-Weight Infants. LID - 10.3390/nu18030460 [doi] LID - 460 AB - Objectives: To identify factors associated with postnatal growth failure (PGF) in very-low-birth-weight (VLBW) infants and to develop a model for the early identification of neonates at risk. Methods: This retrospective cohort study included VLBW infants born between 2014 and 2024. PGF was defined using the 2013 Fenton growth chart. Multivariate logistic regression was used to identify predictors of PGF, and a weighted risk score was derived from their relative contributions. Model performance was evaluated using a receiver operating characteristic (ROC) curve. Results: Among 481 VLBW infants, 334 (69.4%) had PGF. Independent predictors were birth weight < 750 g (adjusted odds ratio [aOR] 8.11; 95% confidence interval [CI], 3.01-21.83), birth weight 750-1000 g (aOR 2.39; 95% CI, 1.35-4.21), multiple births (aOR 2.82; 95% CI, 1.71-4.67), pregnancy-induced hypertension (PIH) (aOR 3.32; 95% CI, 2.02-5.46), oligohydramnios (aOR 4.08; 95% CI, 1.68-9.92), no antenatal corticosteroid exposure (aOR 2.97; 95% CI, 1.65-5.36), and formula or mixed feeding (aOR 1.69; 95% CI, 1.08-2.64). The model showed good discrimination for scores >/=2 (area under the ROC curve, 0.736; sensitivity, 71.6%; specificity, 64.5%). Conclusions: Birth weight < 1000 g, multiple births, PIH, oligohydramnios, no antenatal corticosteroid exposure, and formula or mixed feeding were significant predictors of PGF. The score may support early risk stratification and prompt closer nutritional surveillance. FAU - Singhasem, Nutcha AU - Singhasem N AD - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand. FAU - Maneenil, Gunlawadee AU - Maneenil G AUID- ORCID: 0000-0002-6332-3216 AD - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand. FAU - Thatrimontrichai, Anucha AU - Thatrimontrichai A AUID- ORCID: 0000-0003-2363-6362 AD - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand. FAU - Praditaukrit, Manapat AU - Praditaukrit M AUID- ORCID: 0000-0002-9176-7383 AD - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand. FAU - Dissaneevate, Supaporn AU - Dissaneevate S AD - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand. LA - eng PT - Journal Article DEP - 20260130 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - *Infant, Very Low Birth Weight/growth & development MH - Retrospective Studies MH - Humans MH - Male MH - Female MH - Infant, Newborn MH - *Growth Disorders/diagnosis/etiology MH - *Risk Assessment/methods/standards MH - *Predictive Learning Models MH - Predictive Value of Tests MH - Reproducibility of Results MH - ROC Curve MH - *Infant, Premature/growth & development MH - Risk Factors PMC - PMC12899935 OTO - NOTNLM OT - extrauterine growth retardation OT - postnatal growth failure OT - predictions OT - preterm infant OT - risk factors COIS- The authors declare no conflicts of interest manuscript. EDAT- 2026/02/13 06:32 MHDA- 2026/02/13 06:33 PMCR- 2026/01/30 CRDT- 2026/02/13 01:08 PHST- 2026/01/06 00:00 [received] PHST- 2026/01/24 00:00 [revised] PHST- 2026/01/27 00:00 [accepted] PHST- 2026/02/13 06:33 [medline] PHST- 2026/02/13 06:32 [pubmed] PHST- 2026/02/13 01:08 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - nu18030460 [pii] AID - nutrients-18-00460 [pii] AID - 10.3390/nu18030460 [doi] PST - epublish SO - Nutrients. 2026 Jan 30;18(3):460. doi: 10.3390/nu18030460. PMID- 41682642 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260213 LR - 20260216 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 3 DP - 2026 Jan 25 TI - Hip Joint Synovial Cavity Thickness in Early Juvenile Idiopathic Arthritis Without Effusion: A Cross-Sectional Ultrasound Study. LID - 10.3390/jcm15030962 [doi] LID - 962 AB - Background: The clinical meaning of hip joint synovial cavity thickness (HJSCT) on ultrasound (US) in juvenile idiopathic arthritis (JIA) without effusion is uncertain. Methods: In this cross-sectional study, we analyzed 369 children (187 JIA; 182 controls) undergoing hip US at a referral center in Krakow, Poland. JIA examinations were performed upon initial referral, early in the care pathway. We excluded patients with hip effusion and pre-existing inflammatory, traumatic or degenerative hip pathology. HJSCT was defined as the distance from the outer capsule margin to the femoral neck cortex. We used a Toshiba Aplio 400 system with a 12 MHz probe to measure and derive mean bilateral HJSCT. Bilateral concordance was assessed. Iterative multivariable linear regression modeling was used to compare groups, adjusting for non-linear age effects (natural splines) and WHO height-for-age z-scores (HAZ). Results: Left-right HJSCT agreement was high (ICC 0.947; mean difference 0.03 mm; 95% limits of agreement -0.64-0.70). In unadjusted analysis, mean (SD) HJSCT was similar in JIA versus controls: 5.83 (1.09) vs. 5.95 (0.99) mm, respectively (p = 0.25). In the final model (adj. R2 0.656), HJSCT was strongly associated with age (non-linear, p < 0.001) but not significantly associated with HAZ (beta = 0.04; p = 0.11) or JIA status (beta = 0.07; p = 0.30). Predicted HJSCT showed a steep increment in childhood and plateau in adolescence. Conclusions: In children without hip effusion, HJSCT mainly reflects physiological growth and does not differ significantly between early JIA patients and healthy controls. These findings suggest that capsular thickening is not a reliable standalone marker for early disease in the absence of effusion. FAU - Zuber, Zbigniew AU - Zuber Z AD - Department of Pediatrics, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, 30-705 Krakow, Poland. FAU - Kmiecik, Wojciech AU - Kmiecik W AD - Department of Pediatrics, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, 30-705 Krakow, Poland. FAU - Batko, Krzysztof AU - Batko K AUID- ORCID: 0009-0009-5711-4870 AD - Department of Dermatology, University Hospital, 31-503 Krakow, Poland. FAU - Mezyk, Elzbieta AU - Mezyk E AD - Department of Pediatrics, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, 30-705 Krakow, Poland. FAU - Ozga, Joanna AU - Ozga J AUID- ORCID: 0000-0002-2675-6848 AD - Department of Pediatrics, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, 30-705 Krakow, Poland. FAU - Krajewska-Wlodarczyk, Magdalena AU - Krajewska-Wlodarczyk M AD - Department of Rheumatology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-900 Olsztyn, Poland. FAU - Madej, Tomasz AU - Madej T AD - Department of Pediatric Radiology, University Children's Hospital, 20-093 Lublin, Poland. FAU - Batko, Bogdan AU - Batko B AUID- ORCID: 0000-0003-3999-8093 AD - Department of Rheumatology and Immunology, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski University, 30-705 Krakow, Poland. LA - eng PT - Journal Article DEP - 20260125 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC12897779 OTO - NOTNLM OT - hip joint synovial cavity thickness OT - juvenile idiopathic arthritis OT - pediatric OT - reference OT - ultrasound COIS- The authors declare no conflicts of interest. EDAT- 2026/02/13 06:32 MHDA- 2026/02/13 06:33 PMCR- 2026/01/25 CRDT- 2026/02/13 01:06 PHST- 2025/12/23 00:00 [received] PHST- 2026/01/16 00:00 [revised] PHST- 2026/01/20 00:00 [accepted] PHST- 2026/02/13 06:33 [medline] PHST- 2026/02/13 06:32 [pubmed] PHST- 2026/02/13 01:06 [entrez] PHST- 2026/01/25 00:00 [pmc-release] AID - jcm15030962 [pii] AID - jcm-15-00962 [pii] AID - 10.3390/jcm15030962 [doi] PST - epublish SO - J Clin Med. 2026 Jan 25;15(3):962. doi: 10.3390/jcm15030962. PMID- 41682210 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260213 LR - 20260216 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 3 DP - 2026 Jan 30 TI - Associations Between 24 h Movement Behaviours and Cognitive Abilities in Slovak Adolescents: A Cross-Sectional Study. LID - 10.3390/healthcare14030360 [doi] LID - 360 AB - BACKGROUND: Twenty-four-hour movement behaviours (physical activity, sedentary time, and sleep) may be associated with adolescent cognitive performance, but evidence from Central/Eastern Europe is limited. METHODS: A total of 82 Slovak adolescents (15-19 years) completed tests of IQ, attention, and visual memory. Participants wore a wrist accelerometer 24/7 for seven consecutive days (processed in GGIR v3.0-3). Moderate-to-vigorous physical activity (MVPA), total sedentary time, and sleep duration were derived from accelerometry; physical activity was also self-reported using the Physical Activity Questionnaire for Adolescents (PAQ-A). Non-parametric tests and Spearman correlations were applied; sleep x MVPA interaction models (robust HC3 standard errors) were adjusted for age and sex. RESULTS: MVPA was low (median 32.9 min/day; 11% met >/=60 min/day), while sedentary time was high (median 652.6 min/day). Associations between movement behaviours and cognition were generally small, and no sleep x MVPA interaction effects were observed. The PAQ-A overestimated device-based MVPA (mean bias +1.68 units; 95% limits of agreement +1.10 to +2.25), with greater overestimation in girls and older adolescents. CONCLUSIONS: In this convenience sample, 24 h movement patterns were suboptimal, and their associations with cognition were modest and exploratory. Larger longitudinal studies are needed to confirm these findings. FAU - Ruzbarska, Beata AU - Ruzbarska B AUID- ORCID: 0000-0002-9000-0527 AD - Faculty of Sport, University of Presov, 17. Novembra 15, 080 01 Presov, Slovakia. FAU - Hnidkova, Lenka AU - Hnidkova L AUID- ORCID: 0000-0002-6028-2738 AD - Faculty of Sport, University of Presov, 17. Novembra 15, 080 01 Presov, Slovakia. FAU - Trebunak, Mojmir AU - Trebunak M AD - Faculty of Sport, University of Presov, 17. Novembra 15, 080 01 Presov, Slovakia. FAU - Chovanova, Erika AU - Chovanova E AUID- ORCID: 0000-0002-3197-3425 AD - Faculty of Sport, University of Presov, 17. Novembra 15, 080 01 Presov, Slovakia. FAU - Dzugas, Dalibor AU - Dzugas D AUID- ORCID: 0000-0002-4281-0437 AD - Faculty of Sport, University of Presov, 17. Novembra 15, 080 01 Presov, Slovakia. FAU - Kacur, Peter AU - Kacur P AUID- ORCID: 0000-0001-7682-0871 AD - Faculty of Sport, University of Presov, 17. Novembra 15, 080 01 Presov, Slovakia. LA - eng GR - 1/0481/22/Slovak Republic and the Slovak Academy of Sciences (VEGA)/ PT - Journal Article DEP - 20260130 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12897161 OTO - NOTNLM OT - 24 h movement behaviours OT - PAQ-A OT - accelerometry OT - adolescent cognition OT - physical activity OT - sedentary behaviour OT - sleep COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study, the collection, analysis, or interpretation of data, the writing of the manuscript, or the decision to publish the results. EDAT- 2026/02/13 06:32 MHDA- 2026/02/13 06:33 PMCR- 2026/01/30 CRDT- 2026/02/13 01:05 PHST- 2025/11/27 00:00 [received] PHST- 2025/12/23 00:00 [revised] PHST- 2026/01/28 00:00 [accepted] PHST- 2026/02/13 06:33 [medline] PHST- 2026/02/13 06:32 [pubmed] PHST- 2026/02/13 01:05 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - healthcare14030360 [pii] AID - healthcare-14-00360 [pii] AID - 10.3390/healthcare14030360 [doi] PST - epublish SO - Healthcare (Basel). 2026 Jan 30;14(3):360. doi: 10.3390/healthcare14030360. PMID- 41679965 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1552-4167 (Electronic) IS - 0145-4455 (Linking) VI - 50 IP - 3 DP - 2026 May TI - Cross-Cultural Adaptation, Validation, and Factor Analysis of a Persian Version of the Behavioral Pediatric Feeding Assessment Scale. PG - 192-211 LID - 10.1177/01454455261416517 [doi] AB - Feeding disorders in early childhood involve maladaptive mealtime behaviors, nutritional deficits, and strained parent-child interactions. Standardized tools for Persian-speaking populations are scarce. This study translated and adapted the Behavioral Pediatrics Feeding Assessment Scale (BPFAS) into Persian and evaluated its psychometric properties. The process included translation/adaptation and psychometric testing. Content validity was reviewed by 14 experts, face validity by interviews with 25 mothers, and construct validity via factor analysis with 203 mothers. Reliability was assessed through internal consistency and test-retest stability. Interviews refined the questionnaire format. Factor analysis yielded five child subscales and three parent subscales, explaining 45.11% and 56.72% of variance. The scale demonstrated strong reliability (Cronbach's alpha = .94; ICC = 0.94). Findings confirm that the Persian BPFAS is a reliable and valid tool for assessing feeding disorders in children in Persian-speaking families. Its multidimensional factor structure highlights the complexity of feeding problems and supports its use for early identification and behavioral intervention planning in clinical and community settings. FAU - Parvizi, Soheila AU - Parvizi S AD - Isfahan University of Medical Sciences, Iran. FAU - Jokar, Fariba AU - Jokar F AD - Isfahan University of Medical Sciences, Iran. FAU - Ostadi, Marziyeh AU - Ostadi M AD - Isfahan University of Medical Sciences, Iran. AD - University of Wisconsin-Madison, USA. FAU - Poorjavad, Marziyeh AU - Poorjavad M AUID- ORCID: 0000-0003-4066-4971 AD - Isfahan University of Medical Sciences, Iran. LA - eng PT - Journal Article PT - Validation Study DEP - 20260212 PL - United States TA - Behav Modif JT - Behavior modification JID - 7803043 SB - IM MH - Humans MH - Psychometrics MH - Factor Analysis, Statistical MH - Reproducibility of Results MH - Female MH - Iran MH - Child, Preschool MH - *Feeding and Eating Disorders of Childhood/diagnosis MH - Male MH - Surveys and Questionnaires MH - Cross-Cultural Comparison MH - Child MH - *Feeding Behavior/psychology OTO - NOTNLM OT - behavioral assessment OT - feeding disorders OT - parent-child interaction OT - pediatric OT - psychometrics OT - validation COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/02/13 01:27 MHDA- 2026/04/10 12:59 CRDT- 2026/02/12 21:32 PHST- 2026/04/10 12:59 [medline] PHST- 2026/02/13 01:27 [pubmed] PHST- 2026/02/12 21:32 [entrez] AID - 10.1177/01454455261416517 [doi] PST - ppublish SO - Behav Modif. 2026 May;50(3):192-211. doi: 10.1177/01454455261416517. Epub 2026 Feb 12. PMID- 41679752 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2150-1327 (Electronic) IS - 2150-1319 (Print) IS - 2150-1319 (Linking) VI - 17 DP - 2026 Jan-Dec TI - Translation and Validation of English Version of Screen Dependency Scale (SDS) Among Preschool Children. PG - 21501319261419940 LID - 10.1177/21501319261419940 [doi] LID - 21501319261419940 AB - The Screen Dependency Scale (SDS) is a parent-report tool designed to assess screen media dependency in preschool children which was originally developed in Malay within the Malaysian community. This study aimed to translate and validate the English version of the Screen Dependency Scale (SDS) to enable broader participation, particularly in urban areas where English is widely used. Phase 1 involved forward and backward translation by 2 language experts. An addiction specialist reviewed the back-translated version against the original followed by Face Validity by 14 parents. Phase 2 consisted of a cross-sectional study involving 195 parents of children aged 4 to 6 years. Construct validity was tested using exploratory factor analysis (EFA) followed by confirmatory factor analysis (CFA). CFA showed all items had factor loadings of 0.50 or higher. Model fit indices (RMSEA = 0.08; CFI = 0.92) indicated a good fit. The English SDS demonstrated excellent internal consistency (Cronbach's alpha = .89). Thus, the English version is a valid and reliable tool for assessing screen dependency in Malaysian preschoolers. FAU - Abdul Hadi, Azwanis AU - Abdul Hadi A AUID- ORCID: 0000-0002-1624-0821 AD - International Islamic University Malaysia, Kuantan, Pahang, Malaysia. FAU - Zainoren, Nadirah AU - Zainoren N AD - International Islamic University Malaysia, Kuantan, Pahang, Malaysia. FAU - Said, Abdul Hadi AU - Said AH AUID- ORCID: 0000-0001-8726-9464 AD - International Islamic University Malaysia, Kuantan, Pahang, Malaysia. FAU - Zainal Abidin, Muhammad 'Adil AU - Zainal Abidin M' AUID- ORCID: 0000-0001-6108-1180 AD - International Islamic University Malaysia, Kuantan, Pahang, Malaysia. LA - eng PT - Journal Article PT - Validation Study DEP - 20260212 PL - United States TA - J Prim Care Community Health JT - Journal of primary care & community health JID - 101518419 SB - IM MH - Humans MH - Malaysia MH - Child, Preschool MH - Psychometrics MH - Reproducibility of Results MH - Cross-Sectional Studies MH - Factor Analysis, Statistical MH - Female MH - Male MH - Child MH - Surveys and Questionnaires/standards MH - Translations MH - Parents MH - *Screen Time MH - *Internet Addiction Disorder/diagnosis PMC - PMC12901900 OTO - NOTNLM OT - English translation OT - Malaysia OT - Screen Dependency Scale (SDS) OT - parent-report questionnaire OT - preschool children OT - psychometric validation OT - screen dependency OT - screen time COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/02/13 01:27 MHDA- 2026/02/13 01:28 PMCR- 2026/02/12 CRDT- 2026/02/12 19:53 PHST- 2026/02/13 01:28 [medline] PHST- 2026/02/13 01:27 [pubmed] PHST- 2026/02/12 19:53 [entrez] PHST- 2026/02/12 00:00 [pmc-release] AID - 10.1177_21501319261419940 [pii] AID - 10.1177/21501319261419940 [doi] PST - ppublish SO - J Prim Care Community Health. 2026 Jan-Dec;17:21501319261419940. doi: 10.1177/21501319261419940. Epub 2026 Feb 12. PMID- 41679234 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1532-1983 (Electronic) IS - 0261-5614 (Linking) VI - 58 DP - 2026 Mar TI - Design and validation of kineanthropometric measurement protocols in adult population with cerebral palsy. PG - 106572 LID - S0261-5614(25)00352-8 [pii] LID - 10.1016/j.clnu.2025.106572 [doi] AB - BACKGROUND & AIMS: Adults with cerebral palsy (CP) face a high risk of malnutrition, yet most nutritional assessment methods have been developed for children. Despite the known anatomical and functional heterogeneity in adults with CP, there is a lack of validated, adapted tools for this population. This study aims to design and validate a specific anthropometric method for assessing the nutritional status of adults with CP, addressing this critical gap in clinical and research practice. METHODS: This cross-sectional study consisted of two phases. First, anthropometric measurements were performed on 47 adults with CP to identify practical challenges and design an adapted protocol. In the second phase, this protocol was applied to 74 healthy adults trained to simulate the postural limitations commonly observed in individuals with CP (e.g., asymmetries, spasticity-related contractures), based on direct observation in the CP group. Measurements obtained with the adapted method were statistically compared to those obtained using the International Society for the Advancement of Kinanthropometry (ISAK) reference protocol. RESULTS: The adapted protocol accounts for the anatomical and functional challenges of individuals with CP by allowing measurements to be performed in a supine position or with limbs flexed or extended, as necessary. Statistical analysis revealed no significant differences between the adapted protocol and the ISAK reference method for any of the anthropometric measurements. These results confirm that the modified approach yields accurate and reliable assessments of nutritional status in adults with CP. CONCLUSION: The anatomical and functional limitations of adults with CP present significant challenges to traditional ISAK methodology. However, the adapted protocol, performed in a supine position by trained anthropometrists, produces comparable results. Key indicators such as Arm Muscle Area, Arm Adipose Area, and the Adipose-Muscular Index can reliably assess the nutritional status of this population, offering a viable alternative for clinical and research applications.. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Exposito, David AU - Exposito D AD - Department of Preventive Medicine, University of Valencia, Faculty of Pharmacy and Food Sciences, Burjassot, Valencia, 46100, Spain; Department of Nutrition, Universidad Catolica de Valencia, Faculty of Medicine and Health Sciences Valencia, Valencia, 46001 Spain; Department of Physiotherapy, Universidad Europea de Valencia, Faculty of Health Sciences, Valencia, 46010, Spain. Electronic address: Carla.soler@uv.es. FAU - Soriano, Jose Miguel AU - Soriano JM AD - Joint Research Unit on Endocrinology, Nutrition and Clinical Dietetics UV-IIS La Fe, Valencia, 46012, Spain; Food&Health Lab, Instituto de Ciencias de los Materiales, Universitat de Valencia, Paterna, Valencia, 46980 Spain. FAU - Soler, Carla AU - Soler C AD - Department of Preventive Medicine, University of Valencia, Faculty of Pharmacy and Food Sciences, Burjassot, Valencia, 46100, Spain; Joint Research Unit on Endocrinology, Nutrition and Clinical Dietetics UV-IIS La Fe, Valencia, 46012, Spain. LA - eng PT - Journal Article PT - Validation Study DEP - 20260102 PL - England TA - Clin Nutr JT - Clinical nutrition (Edinburgh, Scotland) JID - 8309603 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology/complications MH - Adult MH - Male MH - Female MH - *Nutrition Assessment MH - *Anthropometry/methods MH - Cross-Sectional Studies MH - Nutritional Status MH - Young Adult MH - Reproducibility of Results MH - Middle Aged MH - Malnutrition/diagnosis/etiology OTO - NOTNLM OT - Body composition measurements OT - Cerebral palsy OT - Kinanthropometry OT - Nutritional assessment COIS- Conflict of interest All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript. EDAT- 2026/02/13 01:27 MHDA- 2026/03/06 13:44 CRDT- 2026/02/12 18:09 PHST- 2025/03/31 00:00 [received] PHST- 2025/12/22 00:00 [revised] PHST- 2025/12/24 00:00 [accepted] PHST- 2026/03/06 13:44 [medline] PHST- 2026/02/13 01:27 [pubmed] PHST- 2026/02/12 18:09 [entrez] AID - S0261-5614(25)00352-8 [pii] AID - 10.1016/j.clnu.2025.106572 [doi] PST - ppublish SO - Clin Nutr. 2026 Mar;58:106572. doi: 10.1016/j.clnu.2025.106572. Epub 2026 Jan 2. PMID- 41679230 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1476-5616 (Electronic) IS - 0033-3506 (Linking) VI - 253 DP - 2026 Apr TI - The associations of maternal exposure to PM(1) during pregnancy with emotional and behavioral problems in offspring: The interaction effect of maternal diet. PG - 106195 LID - S0033-3506(26)00064-8 [pii] LID - 10.1016/j.puhe.2026.106195 [doi] AB - OBJECTIVES: We aimed to examine the association between PM(1) exposure during different stages of pregnancy and emotional and behavioral problems in offspring, and to evaluate whether maternal diet quality interacts with these relationships. STUDY DESIGN: Birth cohort study. METHODS: This cohort study included 391 mother-child pairs from Guangzhou, China. Prenatal PM(1) exposure was estimated using a spatiotemporal model. Maternal diet was assessed via a validated food frequency questionnaire and scored using the Chinese Healthy Eating Index (CHEI). At age 5, offspring's emotional and behavioral problems were evaluated with the Strengths and Difficulties Questionnaire, including emotional, conduct, hyperactivity, peer relationship problems, prosocial behavior, and total difficulties. Generalized linear models were used to examine the association. RESULTS: Overall, 15.9% of children exhibited at least one type of emotional and behavioral problem. The mean maternal PM(1) was 17.51 +/- 2.38 mug/m(3). Each interquartile range (IQR) increase in PM(1) concentration during the first trimester was associated with elevated risk of offspring behavioral problems (OR = 2.25; 95% CI: 1.06 approximately 4.89). Increased PM(1) exposure during both the first (OR = 2.90; 1.07 approximately 8.21) and second trimesters (OR = 4.50; 1.23 approximately 16.76) was linked to higher odds of total difficulties. Higher maternal CHEI scores, particularly the total score and dark vegetable intake component, were associated with weaker PM(1)-related associations. CONCLUSION: Maternal exposure to PM(1) during pregnancy, especially during the first and second trimesters, was associated with an increased risk of emotional and behavioral problems in offspring. A high-quality maternal diet, particularly one rich in vegetables, may mitigate these adverse effects. CI - Copyright (c) 2026 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved. FAU - Li, Mengfan AU - Li M AD - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China. FAU - Zhang, Guoyu AU - Zhang G AD - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China. FAU - He, Xuanqing AU - He X AD - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China. FAU - Gu, Xiaonan AU - Gu X AD - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China. FAU - Zhuang, Weiyin AU - Zhuang W AD - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China. FAU - Wang, Chang AU - Wang C AD - Experimental Teaching Center, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China. FAU - Liu, Yu AU - Liu Y AD - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China. FAU - Liu, Shun AU - Liu S AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, People's Republic of China. FAU - Wang, Xin AU - Wang X AD - Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, Institute for Brain Research and Rehabilitation, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, Guangdong，, People's Republic of China. FAU - Wang, Zhen AU - Wang Z AD - Department of Science and Education, Shenzhen Birth Cohort Study Center, Nanshan Maternity and Child Healthcare Hospital of Shenzhen, Shenzhen, Guangdong, People's Republic of China. FAU - Cai, Li AU - Cai L AD - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China. Electronic address: caili5@mail.sysu.edu.cn. LA - eng PT - Journal Article DEP - 20260211 PL - Netherlands TA - Public Health JT - Public health JID - 0376507 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Prenatal Exposure Delayed Effects/epidemiology MH - China/epidemiology MH - *Diet/statistics & numerical data MH - Child, Preschool MH - Adult MH - *Maternal Exposure/adverse effects MH - *Problem Behavior MH - Birth Cohort MH - *Child Behavior Disorders/epidemiology MH - Cohort Studies OTO - NOTNLM OT - Children OT - Diet OT - Emotional and behavioral problems OT - PM(1) OT - Pregnancy COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/02/13 01:27 MHDA- 2026/03/20 00:59 CRDT- 2026/02/12 18:09 PHST- 2025/10/09 00:00 [received] PHST- 2026/01/23 00:00 [revised] PHST- 2026/02/06 00:00 [accepted] PHST- 2026/03/20 00:59 [medline] PHST- 2026/02/13 01:27 [pubmed] PHST- 2026/02/12 18:09 [entrez] AID - S0033-3506(26)00064-8 [pii] AID - 10.1016/j.puhe.2026.106195 [doi] PST - ppublish SO - Public Health. 2026 Apr;253:106195. doi: 10.1016/j.puhe.2026.106195. Epub 2026 Feb 11. PMID- 41678855 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260920 IS - 1094-6950 (Print) IS - 1094-6950 (Linking) VI - 29 IP - 2 DP - 2026 Apr-Jun TI - Visceral adipose tissue in obesity: A comparison between DXA and MRI measures. PG - 101679 LID - S1094-6950(26)00013-2 [pii] LID - 10.1016/j.jocd.2026.101679 [doi] AB - While magnetic resonance imaging (MRI) accurately measures visceral adipose tissue (VAT), it is costly and time-consuming. Dual X-ray absorptiometry (DXA) offers a faster, more affordable alternative. However, prior comparisons between DXA and MRI often involve different anatomical locations, limiting accuracy assessments. This study aims to compare VAT volume measurements from DXA and MRI at the same anatomical location (L3 vertebra). We hypothesized that both methods would yield similar VAT results. Methodology This is a retrospective, cross-sectional study that analyzed 50 pairs of matched MRI and DXA scans from 28 non-diabetic participants with obesity (18-65 years, BMI range of >/=30 to /= 2.05 x 10(9)/L, a neutrophil-to-lymphocyte ratio (NLR) 60 scores). CONCLUSIONS: Our predictive model, based on routine peripheral blood cell results at 20-24 weeks of gestation, could provide insight into earlier prediction of FGR occurrence in patients with PE, facilitating further fetal monitoring and clinical decision-making. CI - (c) 2026. The Author(s). FAU - Li, Na AU - Li N AD - Department of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Xueshi Rd NO. 1, Hangzhou, 310006, Zhejiang, People's Republic of China. FAU - Shu, Shu-Juan AU - Shu SJ AD - Department of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Xueshi Rd NO. 1, Hangzhou, 310006, Zhejiang, People's Republic of China. FAU - Wang, Miao-Miao AU - Wang MM AD - Department of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Xueshi Rd NO. 1, Hangzhou, 310006, Zhejiang, People's Republic of China. FAU - Xu, Shu-Hang AU - Xu SH AD - Department of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Xueshi Rd NO. 1, Hangzhou, 310006, Zhejiang, People's Republic of China. FAU - Huang, Xiao-Xiu AU - Huang XX AD - Department of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Xueshi Rd NO. 1, Hangzhou, 310006, Zhejiang, People's Republic of China. FAU - Li, Bao-Hua AU - Li BH AD - Department of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Xueshi Rd NO. 1, Hangzhou, 310006, Zhejiang, People's Republic of China. lbh19787@zju.edu.cn. LA - eng GR - LY24H040003/Natural Science Foundation of Zhejiang Province/ GR - ZDFY2021-4X206/4+X Clinical Research Project of Women's Hospital, School of Medicine, Zhejiang University/ PT - Journal Article DEP - 20260211 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Nomograms MH - *Fetal Growth Retardation/diagnosis/blood/etiology MH - Retrospective Studies MH - *Pre-Eclampsia/blood MH - Case-Control Studies MH - Adult MH - China MH - Blood Cell Count MH - Pregnancy Trimester, Second/blood MH - Predictive Value of Tests MH - Gestational Age MH - Risk Factors PMC - PMC12998305 OTO - NOTNLM OT - Blood cell count OT - Fetal growth restriction OT - Nomogram OT - Preeclampsia COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of the Women's Hospital, School of Medicine, Zhejiang University (IRB-20250279-R). All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The requirement for informed consent was waived off by the Ethics Committee of the Women's Hospital, School of Medicine, Zhejiang University. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/11 00:39 MHDA- 2026/03/19 07:11 PMCR- 2026/02/11 CRDT- 2026/02/10 23:49 PHST- 2025/09/08 00:00 [received] PHST- 2026/02/04 00:00 [accepted] PHST- 2026/03/19 07:11 [medline] PHST- 2026/02/11 00:39 [pubmed] PHST- 2026/02/10 23:49 [entrez] PHST- 2026/02/11 00:00 [pmc-release] AID - 10.1186/s12884-026-08783-1 [pii] AID - 8783 [pii] AID - 10.1186/s12884-026-08783-1 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Feb 11;26(1):296. doi: 10.1186/s12884-026-08783-1. PMID- 41665677 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1432-086X (Electronic) IS - 0174-1551 (Linking) VI - 49 IP - 5 DP - 2026 May TI - The Prognostic Nutritional Index (PNI) as a Biomarker for Predicting Survival in Hepatocellular Carcinoma Patients Treated with Transarterial Chemoembolization and Lenvatinib, With or Without Programmed Death-1(PD-1) Inhibitors. PG - 924-936 LID - 10.1007/s00270-025-04334-x [doi] AB - PURPOSE: Current treatment strategies for hepatocellular carcinoma (HCC) using transarterial chemoembolization (TACE) combined with lenvatinib and immunotherapy remain largely empirical due to the lack of reliable biomarkers. This study aimed to evaluate the prognostic significance of the Prognostic Nutritional Index (PNI) in HCC patients treated with TACE plus lenvatinib, with or without programmed death-1 (PD-1) inhibitors. MATERIALS AND METHODS: We conducted a retrospective analysis of 237 patients with HCC who received TACE and lenvatinib-based therapy, with or without PD-1 inhibitors, between March 2021 and September 2023. Patients were randomly allocated into training and validation sets in a 7:3 ratio and stratified into low- and high-PNI groups based on an optimal PNI cut-off value. Overall survival (OS) and progression-free survival (PFS) were compared between the PNI groups using the log-rank test. RESULTS: In both the training and validation sets, patients with higher PNI scores demonstrated significantly better OS and PFS than those with lower PNI scores. Multivariate Cox regression identified PNI score, treatment modality (TACE + lenvatinib +/- PD-1 inhibitor), tumor diameter, alpha-fetoprotein (AFP), and alanine aminotransferase (ALT) as independent prognostic factors for OS. For PFS, independent predictors included PNI score, treatment modality, tumor diameter, Child-Pugh class, and AFP level. Subgroup analyses consistently showed superior OS in the high-PNI group across most strata, including those defined by treatment type, presence of portal vein tumor thrombosis (PVTT) or extrahepatic metastasis (EHM), AFP level ( 400 ng/mL), and Barcelona Clinic Liver Cancer (BCLC) stage C. CONCLUSION: The PNI score is a promising biomarker for predicting survival in HCC patients receiving TACE combined with lenvatinib, with or without PD-1 inhibitors. Low PNI is associated with poor survival outcomes, highlighting its potential utility in risk stratification and treatment planning. CI - (c) 2026. Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE). FAU - Xu, Wenji AU - Xu W AD - College of Medical Imaging, Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China. FAU - Yan, Zhening AU - Yan Z AD - Department of Hepatobiliary Surgery, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China. FAU - Zhao, Yushan AU - Zhao Y AD - Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, 030001, China. FAU - Guo, Peng AU - Guo P AD - Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China. FAU - Wang, Rong AU - Wang R AD - Department of Oncology and Vascular Intervention, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China. FAU - Zhang, Rui AU - Zhang R AD - Department of Hepatobiliary Surgery, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China. FAU - Feng, Duiping AU - Feng D AD - Department of Oncology and Vascular Intervention, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China. FAU - Zhang, Ruiping AU - Zhang R AD - The Radiology Department of Shanxi Provincial People's Hospital, The Fifth Hospital of Shanxi Medical University, Taiyuan, 030001, China. zrp_7142@sxmu.edu.cn. FAU - Chen, Yi AU - Chen Y AUID- ORCID: 0000-0002-0352-0664 AD - Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China. chenyi@sxbqeh.com.cn. AD - Department of Oncology and Vascular Intervention, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China. chenyi@sxbqeh.com.cn. LA - eng GR - 202303021211201/Natural Science Foundation of Shanxi Province/ GR - 20210302123255/Natural Science Foundation of Shanxi Province/ PT - Journal Article DEP - 20260210 PL - United States TA - Cardiovasc Intervent Radiol JT - Cardiovascular and interventional radiology JID - 8003538 RN - 0 (Phenylurea Compounds) RN - EE083865G2 (lenvatinib) RN - 0 (Quinolines) RN - 0 (Immune Checkpoint Inhibitors) SB - IM MH - Humans MH - *Carcinoma, Hepatocellular/therapy/mortality MH - *Phenylurea Compounds/therapeutic use/administration & dosage MH - *Quinolines/therapeutic use MH - *Liver Neoplasms/therapy/mortality MH - Female MH - Male MH - Retrospective Studies MH - *Chemoembolization, Therapeutic/methods MH - Prognosis MH - Middle Aged MH - *Nutrition Assessment MH - Aged MH - *Immune Checkpoint Inhibitors/therapeutic use OTO - NOTNLM OT - Hepatocellular carcinoma OT - Lenvatinib OT - PD-1 inhibitor OT - Prognostic nutritional index OT - Survival COIS- Declarations. Ethics Approval and Consent to Participate: Institutional Review Board approval was obtained. The Ethics Board of the First Hospital of Shanxi Medical University (approval number: NO.KYYJ-2023-017) has approved for this retrospective study. Written informed consent for the medical treatments (TACE, lenvatinib, and/or PD-1 inhibitors) was obtained from all patients prior to their procedures. This study was performed in accordance with the Declaration of Helsinki and the Ethical Guidelines for Clinical Studies. Consent for Publication: All authors consent for the publication of this manuscript. EDAT- 2026/02/10 13:31 MHDA- 2026/05/08 12:37 CRDT- 2026/02/10 11:15 PHST- 2025/10/07 00:00 [received] PHST- 2025/12/17 00:00 [accepted] PHST- 2026/05/08 12:37 [medline] PHST- 2026/02/10 13:31 [pubmed] PHST- 2026/02/10 11:15 [entrez] AID - 10.1007/s00270-025-04334-x [pii] AID - 10.1007/s00270-025-04334-x [doi] PST - ppublish SO - Cardiovasc Intervent Radiol. 2026 May;49(5):924-936. doi: 10.1007/s00270-025-04334-x. Epub 2026 Feb 10. PMID- 41664686 OWN - NLM STAT- Publisher LR - 20260813 IS - 1556-3316 (Print) IS - 1556-3324 (Electronic) IS - 1556-3316 (Linking) VI - 22 IP - 3 DP - 2026 Feb 6 TI - Translation, Cross-Cultural Adaptation, and Psychometric Evaluation of the Hospital for Special Surgery Pediatric Functional Activity Brief Scale (HSS Pedi-FABS) for Turkish Children and Adolescents. PG - 15563316251412832 LID - 10.1177/15563316251412832 [doi] AB - BACKGROUND: Evaluating physical activity in children is crucial for determining functional limitations and promoting healthy growth. The Hospital for Special Surgery Pediatric Functional Activity Brief Scale (HSS Pedi-FABS) is a valid, concise tool that assesses activity levels of children and adolescents participating in sports. There is currently no validated Turkish version. PURPOSE: We sought to (1) translate and cross-culturally adapt the HSS Pedi-FABS into Turkish and (2) evaluate the scale's psychometric properties in a Turkish pediatric and adolescent population. METHODS: The HSS Pedi-FABS was translated and culturally adapted following established guidelines. Physically active, healthy, and Turkish-speaking children and adolescents aged 8 to 17 years were included in the study. The exclusion criteria were as follows: (1) orthopedic/neurological conditions limiting functional activity, (2) language difficulties that could limit comprehension, (3) cognitive impairments, (4) illiteracy, (5) major organ failure, (6) malignancy, and (7) refusal to participate. Psychometric evaluation included internal consistency (Cronbach's alpha), test-retest (t1-t2) reliability (intraclass correlation coefficient), construct validity (correlation with existing physical activity questionnaires), and floor/ceiling effects. RESULTS: Fifty-five participants were included in the study. The Turkish version of the HSS Pedi-FABS (Turkish HSS Pedi-FABS) showed good internal and excellent test-retest reliability. Construct validity was demonstrated with strong correlations between the Turkish questionnaire and comparator instruments. No floor or ceiling effects were found as the minimum score was observed in <15% of participants (5.5% at t1) and the maximum score was not observed. CONCLUSION: The Turkish HSS Pedi-FABS is a valid and reliable instrument for assessing physical activity in healthy children and adolescents. It can be used for both clinical and research purposes. LEVEL OF EVIDENCE: Level II: validation study. CI - (c) The Author(s) 2026. FAU - Benlidayi, Ilke Coskun AU - Benlidayi IC AUID- ORCID: 0000-0001-6517-5969 AD - Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Cukurova University, Adana, Turkey. FAU - Sariyildiz, Aylin AU - Sariyildiz A AUID- ORCID: 0000-0002-8835-4203 AD - Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Cukurova University, Adana, Turkey. FAU - Deniz, Volkan AU - Deniz V AUID- ORCID: 0000-0003-0779-7721 AD - Department of Physiotherapy and Rehabilitation, Tarsus University Faculty of Health Sciences, Mersin, Turkey. FAU - Sayici, Ezgi Nur AU - Sayici EN AUID- ORCID: 0009-0008-0686-8771 AD - Child Wellness Center, Cukurova University, Adana, Turkey. FAU - Jones, Ruth H AU - Jones RH AUID- ORCID: 0009-0006-3097-0747 AD - Pediatric Orthopedic Surgery Service, Hospital for Special Surgery, New York, NY, USA. FAU - Fabricant, Peter D AU - Fabricant PD AUID- ORCID: 0000-0002-8070-685X AD - Pediatric Orthopedic Surgery Service, Hospital for Special Surgery, New York, NY, USA. LA - eng PT - Journal Article DEP - 20260206 PL - United States TA - HSS J JT - HSS journal : the musculoskeletal journal of Hospital for Special Surgery JID - 101273938 PMC - PMC12882842 OTO - NOTNLM OT - adolescent OT - child OT - cross-cultural comparison OT - exercise OT - surveys and questionnaires OT - validation studies as topic COIS- The authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Peter D. Fabricant, MD, MPH, reports relationships with BICMD, Inc, Clinical Orthopedics and Related Research, HSS ASC Development Network LLC, HS2 LLC, Joint Effort Administrative Services Organization LLC, Osso VR, and Springer Nature. The other authors declared no potential conflicts of interest. EDAT- 2026/02/10 06:31 MHDA- 2026/02/10 06:31 PMCR- 2027/02/06 CRDT- 2026/02/10 03:58 PHST- 2025/08/27 00:00 [received] PHST- 2025/11/18 00:00 [accepted] PHST- 2026/02/10 06:31 [medline] PHST- 2026/02/10 06:31 [pubmed] PHST- 2026/02/10 03:58 [entrez] PHST- 2027/02/06 00:00 [pmc-release] AID - 10.1177_15563316251412832 [pii] AID - 10.1177/15563316251412832 [doi] PST - aheadofprint SO - HSS J. 2026 Feb 6;22(3):15563316251412832. doi: 10.1177/15563316251412832. PMID- 41664575 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1598-6357 (Electronic) IS - 1011-8934 (Print) IS - 1011-8934 (Linking) VI - 41 IP - 6 DP - 2026 Feb 9 TI - Current Practices and Challenges in Pediatric Obesity Management (POM): A Nationwide Survey of Physicians in Korea. PG - e61 LID - 10.3346/jkms.2026.41.e61 [doi] LID - e61 AB - BACKGROUND: Childhood obesity is a critical public health issue that often persists into adulthood, posing significant treatment challenges. Establishing long-term healthy habits is essential, and South Korea has implemented various policies to manage pediatric obesity. However, a gap remains between policy, medical efforts, and actual outcomes. This study aimed to explore physicians' perspectives on clinical practices, awareness of governmental policies, and the key barriers and facilitators in pediatric obesity management (POM). METHODS: The questionnaire was developed through a comprehensive literature review and expert feedback, followed by a validity assessment and pilot study, resulting in a finalized 42-question version. Using a convenience sampling approach, 200 physicians specializing in pediatric obesity were recruited via academic societies and online channels. Data analysis involved descriptive statistics, presenting categorical data as frequencies and percentages, and continuous variables as averages. RESULTS: Among the 200 participating physicians, 87.5% were pediatricians. Most had over five years of experience, and more than half were affiliated with primary clinics. Counseling was the primary treatment approach, with liraglutide being the most commonly used medication. However, POM effectiveness was largely unsatisfactory, with 42.0% considering their efforts a "failure." Only 46.0% reported having institutional protocols, and training experiences varied by institution and region. Awareness and satisfaction with governmental policies were low, with limited recognition of national programs. Physicians emphasized the need for early childhood interventions and stronger medical involvement. Key priorities for improvement included better insurance reimbursement and stronger school partnerships. CONCLUSION: This study lays the groundwork for developing targeted strategies and policies to address the complex challenges of POM, ultimately improving health outcomes across all age groups, particularly children and adolescents. CI - (c) 2026 The Korean Academy of Medical Sciences. FAU - Lee, Yoon AU - Lee Y AUID- ORCID: 0000-0001-9521-3575 AD - Department of Pediatrics, Korea University Anam Hospital, Seoul, Korea. FAU - Shin, Minsoo AU - Shin M AUID- ORCID: 0000-0002-8438-937X AD - Department of Pediatrics, Korea University Ansan Hospital, Ansan, Korea. FAU - Chung, Sochung AU - Chung S AUID- ORCID: 0000-0002-7655-2691 AD - Department of Pediatrics, Konkuk University School of Medicine, Seoul, Korea. AD - Department of Pediatrics, Konkuk University Medical Center, Seoul, Korea. FAU - Jung, Jahye AU - Jung J AUID- ORCID: 0009-0000-0320-7013 AD - Division of Health Technology Assessment Research, National Evidence-based Healthcare Collaborating Agency, Seoul, Korea. FAU - Sul, Ah-Ram AU - Sul AR AUID- ORCID: 0000-0003-0331-5529 AD - Division of Health Technology Assessment Research, National Evidence-based Healthcare Collaborating Agency, Seoul, Korea. ahramsul@neca.re.kr. FAU - Hong, Yong Hee AU - Hong YH AUID- ORCID: 0000-0002-4676-8483 AD - Department of Pediatrics, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea. hongyonghee@schmc.ac.kr. LA - eng GR - NECA-A-24-001/NECA/National Evidence-based Healthcare Collaborating Agency of the Republic of Korea/Korea GR - SCH/Soonchunhyang University/Korea PT - Journal Article DEP - 20260209 PL - Korea (South) TA - J Korean Med Sci JT - Journal of Korean medical science JID - 8703518 SB - IM MH - Humans MH - Republic of Korea MH - Surveys and Questionnaires MH - *Pediatric Obesity/prevention & control MH - Female MH - *Physicians/psychology MH - *Practice Patterns, Physicians' MH - Child MH - Male MH - Adult PMC - PMC12890466 OTO - NOTNLM OT - Korea OT - Pediatric Obesity OT - Physicians OT - Surveys and Questionnaires COIS- The authors have no potential conflicts of interest to disclose. EDAT- 2026/02/10 06:30 MHDA- 2026/02/10 06:31 PMCR- 2026/01/30 CRDT- 2026/02/10 03:03 PHST- 2025/03/03 00:00 [received] PHST- 2025/06/10 00:00 [accepted] PHST- 2026/02/10 06:31 [medline] PHST- 2026/02/10 06:30 [pubmed] PHST- 2026/02/10 03:03 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - 41.e61 [pii] AID - 10.3346/jkms.2026.41.e61 [doi] PST - epublish SO - J Korean Med Sci. 2026 Feb 9;41(6):e61. doi: 10.3346/jkms.2026.41.e61. PMID- 41664328 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2047-6310 (Electronic) IS - 2047-6302 (Print) IS - 2047-6302 (Linking) VI - 21 IP - 2 DP - 2026 Feb TI - Unravelling the Ties: How Attachment Styles and Emotion Regulation Fuel Emotional Eating in Youth With Obesity-A Clinical Sample Study. PG - e70095 LID - 10.1111/ijpo.70095 [doi] LID - e70095 AB - Emotional eating is critical in the development and maintenance of obesity among children and adolescents. While attachment's influence on emotional eating is increasingly recognised, little is known about how emotion regulation strategies mediate this, particularly in samples with obesity. This study examined how attachment dimensions affect emotional eating through different emotion regulation strategies in youths with obesity. 772 children and adolescents (ages 7-19) with obesity participated. Key variables were measured using validated questionnaires. Mediation effects were analysed through Structural Equation Modelling, with exploratory analyses assessing the role of the emotion regulation strategies diversity index and specific emotion regulation strategies. Higher attachment anxiety and avoidance were associated with greater emotional eating, both directly and indirectly through maladaptive emotion regulation strategies. Adaptive strategies did not show mediating effects. Attachment anxiety and avoidance increased the diversity of emotion regulation strategies, which was associated with higher emotional eating. Interventions may benefit from prioritising the effectiveness of these strategies and addressing maladaptive ones. Excessive diversity of emotion regulation strategies could reflect underlying difficulties and may be associated with higher emotional eating. A deeper understanding of the interplay between attachment and emotion regulation could inform more targeted approaches for preventing and treating obesity in youth. CI - (c) 2026 The Author(s). Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation. FAU - Gomez-Odriozola, Joana AU - Gomez-Odriozola J AUID- ORCID: 0000-0001-6004-4927 AD - Department of Clinical and Health Psychology & Research Methods, University of the Basque Country UPV/EHU, Donostia-San Sebastian, Spain. FAU - Braet, Jolien AU - Braet J AUID- ORCID: 0000-0001-8213-2565 AD - Department of Developmental, Personality, and Social Psychology, Ghent University, Ghent, Belgium. FAU - Verbiest, Ine AU - Verbiest I AUID- ORCID: 0000-0002-0854-0488 AD - Department of Developmental, Personality, and Social Psychology, Ghent University, Ghent, Belgium. FAU - Braet, Caroline AU - Braet C AUID- ORCID: 0000-0003-2458-287X AD - Department of Developmental, Personality, and Social Psychology, Ghent University, Ghent, Belgium. LA - eng GR - IT-1797-26/Eusko Jaurlaritza/ GR - PID2023-151085NB-I00/Ministerio de Ciencia e Innovacion/ GR - UES22/27/University of the Basque Country (UPV/EHU)/ GR - MOV23/42/University of the Basque Country (UPV/EHU)/ GR - BOF20/DOC/015/Bijzonder Onderzoeksfonds UGent (BOF)/ GR - FWO.3F0.2021.0087.01/Fonds Wetenschappelijk Onderzoek/ PT - Journal Article PL - England TA - Pediatr Obes JT - Pediatric obesity JID - 101572033 SB - IM MH - Humans MH - *Emotional Eating/psychology MH - Child MH - Adolescent MH - *Emotional Regulation MH - Female MH - Male MH - *Object Attachment MH - *Pediatric Obesity/psychology MH - Surveys and Questionnaires MH - Young Adult MH - *Feeding Behavior/psychology MH - Emotions PMC - PMC12887149 OTO - NOTNLM OT - attachment OT - emotion regulation OT - emotional eating OT - obesity OT - youth COIS- The hypotheses and data analysis plan are preregistered on the Open Science Framework under registration number: https://doi.org/10.17605/OSF.IO/FKQCM. The authors declare no conflicts of interest. EDAT- 2026/02/10 06:30 MHDA- 2026/02/10 06:31 PMCR- 2026/02/10 CRDT- 2026/02/10 00:32 PHST- 2026/01/27 00:00 [revised] PHST- 2025/02/14 00:00 [received] PHST- 2026/02/02 00:00 [accepted] PHST- 2026/02/10 06:31 [medline] PHST- 2026/02/10 06:30 [pubmed] PHST- 2026/02/10 00:32 [entrez] PHST- 2026/02/10 00:00 [pmc-release] AID - IJPO70095 [pii] AID - 10.1111/ijpo.70095 [doi] PST - ppublish SO - Pediatr Obes. 2026 Feb;21(2):e70095. doi: 10.1111/ijpo.70095. PMID- 41664241 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260312 LR - 20260813 IS - 2210-9099 (Print) IS - 2233-6052 (Electronic) IS - 2210-9099 (Linking) VI - 17 IP - 1 DP - 2026 Feb TI - Correlates and co-occurrence of risk factors for non-communicable diseases among adolescents in schools in Karnataka, India: a cross-sectional study. PG - 83-93 LID - 10.24171/j.phrp.2025.0204 [doi] AB - BACKGROUND: Non-communicable disease (NCD) risk among adolescents represents a growing concern due to modifiable, lifestyle-related behavioral risk factors. Early identification and control of these factors are essential for prevention. This study assessed the correlates and cooccurrence of NCD-related lifestyle risk factors among school-going adolescents in Karnataka, India, aiming to inform intervention development. METHODS: Screening was conducted among 1,100 school adolescents aged 13-16 years from 8 randomly selected urban and rural schools in Karnataka. Data were collected using a validated self-administered questionnaire covering sociodemographic characteristics and social cognitive theory predictors of lifestyle practices. Descriptive statistics, chi-square tests, and logistic regression were employed. RESULTS: Of the 1,100 adolescents surveyed, 552 and 548 were from urban and rural areas, respectively. Both groups reported high rates of insufficient fruit and vegetable (FV) intake (96.7% and 67.7%, respectively), inadequate physical activity (96.7% and 68.6%), tobacco use (5.6% and 11.5%), and alcohol consumption (5.6% and 10.8%). On logistic regression, urban adolescents were significantly more likely than rural peers to exhibit multiple behavioral risk factors, with 19-fold higher odds of having >/=1 factor (adjusted odds ratio [AOR], 19.04; p< 0.001) and 4-fold higher odds of having >/=2 (AOR, 4.06; p < 0.001). Parental (particularly maternal) education was associated with NCD risk (AOR, 1.82; p= 0.001). Physical inactivity significantly co-occurred with low FV intake (71.7%) and junk food consumption (72.8%). CONCLUSION: Unhealthy lifestyle behaviors among adolescents displayed significant cooccurrence, underscoring the critical need for comprehensive, theory-based school interventions to address multiple interconnected risk factors and mitigate the burden of NCDs. FAU - Darukaradhya, Tejaswini Bangalore AU - Darukaradhya TB AD - Division of Public Health, Faculty of Life and Allied Health Sciences, M.S. Ramaiah University of Applied Sciences, Bengaluru, India. FAU - Jayanna, Krishnamurthy AU - Jayanna K AD - Center for Integrative Health and Wellbeing, Bengaluru, India. FAU - Somanna, Shivaraj Nallur AU - Somanna SN AD - Department of Community Medicine, Ramaiah Medical College, M.S. Ramaiah University of Applied Sciences, Bengaluru, India. FAU - Sequeira, Sony AU - Sequeira S AD - Division of Public Health, Faculty of Life and Allied Health Sciences, M.S. Ramaiah University of Applied Sciences, Bengaluru, India. FAU - Nooyi, Shalini Chandrashekar AU - Nooyi SC AD - Department of Community Medicine, Ramaiah Medical College, M.S. Ramaiah University of Applied Sciences, Bengaluru, India. LA - eng PT - Journal Article DEP - 20260210 PL - Korea (South) TA - Osong Public Health Res Perspect JT - Osong public health and research perspectives JID - 101563309 PMC - PMC12980643 OTO - NOTNLM OT - Adolescent OT - Health risk behaviors OT - Lifestyle OT - Noncommunicable diseases COIS- Conflicts of Interest The authors have no conflicts of interest to declare. EDAT- 2026/02/10 06:31 MHDA- 2026/02/10 06:32 PMCR- 2026/02/01 CRDT- 2026/02/10 00:21 PHST- 2025/06/10 00:00 [received] PHST- 2026/01/11 00:00 [accepted] PHST- 2026/02/10 06:32 [medline] PHST- 2026/02/10 06:31 [pubmed] PHST- 2026/02/10 00:21 [entrez] PHST- 2026/02/01 00:00 [pmc-release] AID - j.phrp.2025.0204 [pii] AID - j-phrp-2025-0204 [pii] AID - 10.24171/j.phrp.2025.0204 [doi] PST - ppublish SO - Osong Public Health Res Perspect. 2026 Feb;17(1):83-93. doi: 10.24171/j.phrp.2025.0204. Epub 2026 Feb 10. PMID- 41664228 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Feb 9 TI - Physical exercise and adolescent negative emotions: indirect associations via stress perception and emotional sensitivity. LID - 10.1186/s40359-026-04093-5 [doi] LID - 348 AB - BACKGROUND: Adolescent negative emotions are a major public health concern. Physical exercise is often associated with better emotional health, yet the psychological processes underlying this association, particularly in Chinese adolescents, are not fully understood. This study examined whether stress perception and emotional sensitivity are related to the association between physical exercise and negative emotions. METHODS: A cross-sectional survey was conducted with 1,471 adolescents (54.52% male; Mean age = 13.16, SD = 1.01) from ten middle schools in Guangxi Province, China. Validated Chinese versions of established instruments assessed physical exercise (Youth Physical Activity Rating Scale), negative emotions (PANAS Negative Affect subscale), stress perception (Perceived Stress Scale), and emotional sensitivity operationalized through emotional contagion susceptibility. Path analysis using maximum likelihood estimation with robust standard errors tested the hypothesized sequential mediation model. Bootstrap confidence intervals (5,000 resamples) evaluated indirect effects. RESULTS: Path analysis revealed good model fit (chi(2)/df = 3.62, CFI = 0.96, TLI = 0.94, SRMR = 0.05, RMSEA = 0.04). Physical exercise demonstrated significant direct (beta = -0.13, 95% CI [-0.22, -0.09]) and indirect (beta = -0.12, 95% CI [-0.27, -0.08]) associations with negative emotions. Stress perception accounted for 40% of the total association between physical exercise and negative emotions (beta = -0.10, 95% CI [-0.16, -0.07]). The sequential indirect association via stress perception and emotional sensitivity accounted for 8% of the total association (beta = -0.02, 95% CI [-0.05, -0.01]). The direct path from physical exercise to emotional sensitivity was non-significant (beta = -0.04, p = 0.23), which is consistent with an indirect-only pattern via stress perception in the specified model. CONCLUSIONS: The findings are consistent with a sequential mediation model in which physical exercise is associated with lower negative emotions both directly and indirectly, primarily through lower stress perception and, to a lesser extent, through a sequential pathway involving emotional sensitivity. Although the cross-sectional design does not permit causal conclusions, the observed pattern of associations highlights physical exercise and stress perception as important contextual factors to consider when developing strategies to support adolescent emotional health. FAU - Xin, Yang AU - Xin Y AD - Guangxi Orthopedic Hospital, Nanning, China. AD - Guangxi University, Nanning, China. FAU - Liuheng, Lu AU - Liuheng L AD - Guangxi Orthopedic Hospital, Nanning, China. luliuheng809@163.com. LA - eng GR - HESTCG202304/the Health and Emergency Skills Training Center of Guangxi/ GR - Z-A20220394/the Self-financed Scientific Research Project of the Health Commission of Guangxi Zhuang Autonomous Region/ PT - Journal Article DEP - 20260209 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Female MH - Adolescent MH - Cross-Sectional Studies MH - Male MH - *Emotions MH - *Exercise/psychology MH - Subjective Stress MH - China MH - *Stress, Psychological/psychology PMC - PMC12983937 OTO - NOTNLM OT - Adolescents OT - China OT - Emotional sensitivity OT - Negative emotions OT - Physical exercise OT - Stress perception COIS- Declarations. Ethics approval and consent to participate: The Ethics Committee of Guangxi Orthopedic Hospital approved this study (approval no. 20240701; Date: July 8, 2024). The study was conducted in accordance with the Declaration of Helsinki and relevant institutional guidelines and regulations. Written informed consent was obtained from the legal guardians of all participants prior to data collection, and assent was obtained from all participating adolescents. Participation was voluntary. Consent for publication: Not applicable. The manuscript does not contain any individual person's data in any form. Competing interests: The authors declare no competing interests. EDAT- 2026/02/10 06:32 MHDA- 2026/06/27 06:44 PMCR- 2026/02/09 CRDT- 2026/02/10 00:19 PHST- 2025/01/15 00:00 [received] PHST- 2026/01/28 00:00 [accepted] PHST- 2026/06/27 06:44 [medline] PHST- 2026/02/10 06:32 [pubmed] PHST- 2026/02/10 00:19 [entrez] PHST- 2026/02/09 00:00 [pmc-release] AID - 10.1186/s40359-026-04093-5 [pii] AID - 4093 [pii] AID - 10.1186/s40359-026-04093-5 [doi] PST - epublish SO - BMC Psychol. 2026 Feb 9;14(1):348. doi: 10.1186/s40359-026-04093-5. PMID- 41663088 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260813 IS - 1439-1651 (Electronic) IS - 0948-2393 (Linking) VI - 230 IP - 4 DP - 2026 Aug TI - Investigation of serum Agouti-related peptide levels in pregnant women with hyperemesis gravidarum. PG - 300-305 LID - 10.1055/a-2784-5204 [doi] AB - OBJECTIVE: Agouti-related peptide (AgRP) is an orexigenic neuropeptide secreted by the hypothalamus that plays a key role in stimulating appetite and increasing food intake. This study aimed to evaluate circulating AgRP levels in pregnant women diagnosed with hyperemesis gravidarum (HG). METHODS: This cross-sectional case-control study compared serum AgRP levels between two groups of pregnant women. The first group included 44 women aged 18-40 years who were hospitalized during the first trimester due to HG, while the control group consisted of 44 healthy pregnant women without HG, matched for age, body mass index (BMI), and gestational age. RESULTS: Both groups were similar in terms of age, BMI, gravida, parity, and gestational week at which blood samples were taken (p > 0.05 for all). Median serum AgRP level was 211.67 ng/L in the HG group and 182.14 ng/L in the control group (p=0.073). There was a significant positive correlation between AgRP level and maternal BMI as well as urinary ketone positivity (r=0.326, r=0.334, r=0.536, r=0.335; p<0.05, respectively). CONCLUSION: In this study, serum AgRP levels did not differ significantly between the HG and control groups. Although these findings should be interpreted with caution due to the limited sample size, they suggest that AgRP may not play a central role in the pathogenesis of HG. Further prospective studies with larger cohorts are warranted to better elucidate this potential association. CI - Thieme. All rights reserved. FAU - Erdogan, Melek AU - Erdogan M AUID- ORCID: 0009-0002-7012-7579 AD - Department of Gynecology and Obstetrics, Umraniye Training and Research Hospital, Istanbul, Turkey. FAU - Koca Yildirim, Hande Esra AU - Koca Yildirim HE AUID- ORCID: 0000-0002-3715-9424 AD - Department of Gynecology and Obstetrics, Umraniye Training and Research Hospital, Istanbul, Turkey. FAU - Kale, Ibrahim AU - Kale I AUID- ORCID: 0000-0001-7802-7199 AD - Department of Gynecology and Obstetrics, Umraniye Training and Research Hospital, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20260209 PL - Germany TA - Z Geburtshilfe Neonatol JT - Zeitschrift fur Geburtshilfe und Neonatologie JID - 9508901 RN - 0 (Agouti-Related Protein) RN - 0 (Biomarkers) RN - 0 (AGRP protein, human) SB - IM MH - Humans MH - Female MH - *Hyperemesis Gravidarum/blood/diagnosis/epidemiology MH - Pregnancy MH - *Agouti-Related Protein/blood MH - Adult MH - Young Adult MH - Biomarkers/blood MH - Case-Control Studies MH - Adolescent MH - Cross-Sectional Studies MH - Sensitivity and Specificity MH - Reproducibility of Results MH - Reference Values MH - Body Mass Index COIS- The authors declare that they have no conflict of interest. EDAT- 2026/02/10 01:29 MHDA- 2026/08/13 23:36 CRDT- 2026/02/09 19:52 PHST- 2026/08/13 23:36 [medline] PHST- 2026/02/10 01:29 [pubmed] PHST- 2026/02/09 19:52 [entrez] AID - 10.1055/a-2784-5204 [doi] PST - ppublish SO - Z Geburtshilfe Neonatol. 2026 Aug;230(4):300-305. doi: 10.1055/a-2784-5204. Epub 2026 Feb 9. PMID- 41662908 OWN - NLM STAT- MEDLINE DCOM- 20260820 LR - 20260922 IS - 1553-4669 (Electronic) IS - 1553-4650 (Print) IS - 1553-4650 (Linking) VI - 33 IP - 8 DP - 2026 Aug TI - Diagnostic Disparities in Endometriosis and Adenomyosis: Investigating Social Vulnerability and Access to Care in an Ancestrally Diverse Population. PG - 1171-1179.e1 LID - S1553-4650(26)00104-4 [pii] LID - 10.1016/j.jmig.2026.02.010 [doi] AB - STUDY OBJECTIVE: To evaluate differences in the likelihood of endometriosis or adenomyosis diagnosis across genetically-defined ancestry groups (African, Admixed American, East Asian, European, and South Asian), and to determine whether social vulnerability and access to surgery influence diagnostic practices in a diverse urban population. SETTING: Penn Medicine BioBank, a clinical and genomic biorepository. PATIENTS: Female patients aged 18 to 51 enrolled from 2008 to 2020 and followed through March 2024. INTERVENTIONS: Population diversity was characterized using genotyping data from peripheral blood samples. Genetic ancestry was inferred through principal component analysis and clustering with reference populations. Sociocultural factors were assessed as distinct covariates rather than conflated with racial/ethnic identity. Social vulnerability indices (socioeconomic status, family/household factors, and housing/transportation access) were defined by Census tract of the patient's residence. Endometriosis and adenomyosis were identified using International Classification of Diseases-9/10 codes, validated by chart review. Logistic regressions were adjusted for age, body mass index, social vulnerability, and interaction terms. MEASUREMENTS AND MAIN RESULTS: Among 9258 patients, 357 (3.9%) were diagnosed with endometriosis and 464 (5.0%) with adenomyosis. When all diagnostic routes were considered (surgical, imaging, and clinical), the likelihood of endometriosis did not differ by ancestry group. However, the odds of a surgical diagnosis by laparoscopy was significantly lower for patients of African ancestry, compared with European (adjusted OR: 0.57, 95% CI: 0.38-0.85). Socioeconomic vulnerability strongly modified this association: African-ancestry patients with the highest socioeconomic vulnerability had the lowest odds of receiving an endometriosis diagnosis (aOR: 0.29, 0.14-0.61), including surgically confirmed diagnosis (aOR: 0.31, 0.12-0.80), relative to those of European ancestry with lowest vulnerability. By contrast, patients of African ancestry had higher odds of adenomyosis (aOR: 2.88, 2.16-3.85), including cases confirmed by hysterectomy (aOR: 3.44, 2.21-5.36). CONCLUSION: Diagnostic disparities in endometriosis and adenomyosis were most pronounced at the intersection of ancestry and socioeconomic vulnerability, highlighting the need to address social determinants and barriers to equitable care. CI - Copyright (c) 2026 AAGL. Published by Elsevier Inc. All rights reserved. FAU - Humphries, Leigh A AU - Humphries LA AD - Center for Minimally Invasive Gynecologic Surgery, Department of Obstetrics and Gynecology, Newton-Wellesley Hospital, Harvard Medical School, Newton, MA (Humphries). Electronic address: lahumphries@mgb.org. FAU - Rush, Margaret A AU - Rush MA AD - Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA (Rush, Senapati). FAU - Pollie, Meridith AU - Pollie M AD - Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA (Pollie). FAU - Guare, Lindsay AU - Guare L AD - Genomics and Computational Biology, University of Pennsylvania, Philadelphia, PA (Guare). FAU - Okeh, Chelsea AU - Okeh C AD - Interdisciplinary Graduate Program in Biological and Biomedical Sciences, Vanderbilt University School of Medicine, Nashville, TN (Okeh). CN - Penn Medicine BioBank AD - Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA (BioBank, Verma). FAU - Verma, Shefali Setia AU - Verma SS AD - Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA (BioBank, Verma); Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA (Verma). FAU - Senapati, Suneeta AU - Senapati S AD - Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA (Rush, Senapati). LA - eng GR - R01 HD110567/HD/NICHD NIH HHS/United States GR - T32 HG000046/HG/NHGRI NIH HHS/United States PT - Journal Article PT - Observational Study DEP - 20260208 PL - United States TA - J Minim Invasive Gynecol JT - Journal of minimally invasive gynecology JID - 101235322 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Middle Aged MH - Young Adult MH - *Adenomyosis/diagnosis/ethnology MH - *Endometriosis/diagnosis/ethnology MH - *Health Services Accessibility/statistics & numerical data MH - *Healthcare Disparities/ethnology/statistics & numerical data MH - *Social Vulnerability MH - Socioeconomic Disparities in Health MH - White/ethnology/statistics & numerical data MH - Black or African American/ethnology/statistics & numerical data MH - Asian/ethnology/statistics & numerical data PMC - PMC13267626 MID - NIHMS2146491 OTO - NOTNLM OT - Ancestral OT - Biobank OT - Genome sequencing OT - Gynecologic surgery OT - Health inequities OT - Healthcare access OT - Pelvic pain OT - Socioeconomic status EDAT- 2026/02/10 01:29 MHDA- 2026/08/21 03:31 PMCR- 2026/06/16 CRDT- 2026/02/09 19:10 PHST- 2025/12/04 00:00 [received] PHST- 2026/02/04 00:00 [revised] PHST- 2026/02/04 00:00 [accepted] PHST- 2026/08/21 03:31 [medline] PHST- 2026/02/10 01:29 [pubmed] PHST- 2026/02/09 19:10 [entrez] PHST- 2026/06/16 00:00 [pmc-release] AID - S1553-4650(26)00104-4 [pii] AID - 10.1016/j.jmig.2026.02.010 [doi] PST - ppublish SO - J Minim Invasive Gynecol. 2026 Aug;33(8):1171-1179.e1. doi: 10.1016/j.jmig.2026.02.010. Epub 2026 Feb 8. PMID- 41661226 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1535-1815 (Electronic) IS - 0749-5161 (Linking) VI - 42 IP - 6 DP - 2026 Jun 1 TI - Optic Nerve Sheath Diameter in Pediatric Populations: Establishing Reference Intervals and Anthropometric Correlations. PG - 453-460 LID - 10.1097/PEC.0000000000003573 [doi] AB - OBJECTIVES: Ultrasonographic measurement of optic nerve sheath diameter (ONSD) is emerging as a noninvasive method for assessing intracranial pressure (ICP) in children. However, its practical application is limited by the lack of adequate age-specific normative data for healthy children. This study aimed to establish age-specific reference ranges for ONSD in healthy children aged 4 to 18 years and assess how anthropometric factors such as body mass index (BMI), height, and weight affect ONSD measurements. METHODS: This cross-sectional study included 150 healthy children aged 4 to 18 years, with no suspicion of increased ICP or chronic illness. ONSD was measured bilaterally using standardized transorbital ultrasonography. Anthropometric z -scores were calculated and correlations and percentile-based reference intervals were determined. RESULTS: The mean ONSD was 3.67+/-0.50 mm, with higher values in the 11 to 18 years group compared with the 4 to 10 years group (3.80+/-0.45 mm vs. 3.51+/-0.51 mm, P <0.001). ONSD positively correlated with age, height, weight, and BMI in the overall sample. Subgroup analyses revealed that BMI was significantly associated with ONSD only in the 11 to 18 years group. The age-specific 97th percentile upper limits were 4.33 mm (4 to 10 y) and 4.40 mm (11 to 18 y). CONCLUSIONS: This study provides age-specific normative reference intervals for ONSD in healthy children and shows the impact of BMI on ONSD measurements in adolescents. These findings enhance the clinical interpretation of ONSD in pediatric settings and support its integration into noninvasive ICP assessment protocols. Further multicenter studies are required to validate the reference values. CI - Copyright (c) 2026 Wolters Kluwer Health, Inc. All rights reserved. FAU - Erkan, Mine AU - Erkan M AUID- ORCID: 0000-0001-8612-356 AD - Akdeniz University Faculty of Medicine. FAU - Tolu Kendir, Ozlem AU - Tolu Kendir O AD - Akdeniz University Faculty of Medicine. FAU - Gurlu, Ramazan AU - Gurlu R AD - Antalya City Hospital, Antalya, Turkey. FAU - Erkek, Nilgun AU - Erkek N AD - Akdeniz University Faculty of Medicine. LA - eng PT - Journal Article DEP - 20260209 PL - United States TA - Pediatr Emerg Care JT - Pediatric emergency care JID - 8507560 SB - IM MH - Humans MH - Child MH - Adolescent MH - Reference Values MH - Female MH - Child, Preschool MH - Male MH - *Optic Nerve/diagnostic imaging/anatomy & histology MH - Cross-Sectional Studies MH - Ultrasonography/methods MH - Body Mass Index MH - Intracranial Pressure/physiology MH - Anthropometry MH - Age Factors OTO - NOTNLM OT - children OT - intracranial pressure OT - optic nerve sheath diameter (ONSD) OT - pediatric OT - reference ranges COIS- Disclosure: The authors declare no conflict of interest. EDAT- 2026/02/09 12:53 MHDA- 2026/06/01 12:39 CRDT- 2026/02/09 11:04 PHST- 2025/07/21 00:00 [received] PHST- 2026/01/19 00:00 [accepted] PHST- 2026/06/01 12:39 [medline] PHST- 2026/02/09 12:53 [pubmed] PHST- 2026/02/09 11:04 [entrez] AID - 00006565-990000000-00789 [pii] AID - 10.1097/PEC.0000000000003573 [doi] PST - ppublish SO - Pediatr Emerg Care. 2026 Jun 1;42(6):453-460. doi: 10.1097/PEC.0000000000003573. Epub 2026 Feb 9. PMID- 41661161 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1827-1928 (Electronic) IS - 0022-4707 (Linking) VI - 66 IP - 5 DP - 2026 May TI - Somatotype, age, and neuromuscular performance in elite youth football players. PG - 631-641 LID - 10.23736/S0022-4707.25.17476-8 [doi] AB - BACKGROUND: Somatotype has been linked to physical performance in youth athletes, but its independent contribution to power development, particularly in relation to biological maturity, remains underexplored. This study examined whether somatotype and age independently influence neuromuscular performance in elite youth football players and whether these effects persist after normalization for body mass. METHODS: A total of 106 elite male academy players aged 15 to 18 years were classified as mesomorphic or ectomorphic using the Heath-Carter method. Performance tests included vertical jumps from a squat position and with countermovement, lower-limb peak power (estimated via a validated field equation), and an index estimating stretch-shortening cycle efficiency. Relative power (W.kg(-1)) was also calculated to account for body-mass dependence. Analyses included multivariate and variance testing, to explore independent effects of somatotype and age. RESULTS: Mesomorphic players produced significantly higher power output than ectomorphic players; older athletes also exhibited greater power. No interaction was observed between somatotype and age group. However, when normalized to body mass, between-group differences were no longer significant, indicating that the apparent mesomorphic advantage reflected greater mass rather than superior neuromuscular efficiency. No significant somatotype effect was observed for the Elasticity Index (P=0.098). Logistic regression correctly classified 72.6% of somatotypes, but specificity for ectomorphs was very low (11.5%), indicating that power-based profiling is ineffective for identifying ectomorphic players. CONCLUSIONS: Somatotype and age independently influence power performance in elite youth football players. Nevertheless, relative power analysis demonstrated that morphological differences primarily underlie these effects. Power metrics alone lack diagnostic validity for morphological classification and should complement, rather than replace, anthropometric assessment. FAU - Androulakis, Nikolaos AU - Androulakis N AD - Laboratory of Hematology, University Hospital of Iraklion, Iraklion, Greece - nikandgr@gmail.com. FAU - Tsiakiris, Christos AU - Tsiakiris C AD - Greek National U21 Team, Athens, Greece. FAU - Koundourakis, Nikolaos AU - Koundourakis N AD - Performance Department, O.F.I. Football Club, Iraklion, Greece. LA - eng PT - Journal Article DEP - 20260209 PL - Italy TA - J Sports Med Phys Fitness JT - The Journal of sports medicine and physical fitness JID - 0376337 SB - IM MH - Humans MH - Adolescent MH - Male MH - *Athletic Performance/physiology MH - *Somatotypes/physiology MH - Age Factors MH - *Muscle Strength/physiology MH - *Soccer/physiology MH - Exercise Test EDAT- 2026/02/09 12:54 MHDA- 2026/04/21 18:06 CRDT- 2026/02/09 10:45 PHST- 2026/04/21 18:06 [medline] PHST- 2026/02/09 12:54 [pubmed] PHST- 2026/02/09 10:45 [entrez] AID - S0022-4707.25.17476-8 [pii] AID - 10.23736/S0022-4707.25.17476-8 [doi] PST - ppublish SO - J Sports Med Phys Fitness. 2026 May;66(5):631-641. doi: 10.23736/S0022-4707.25.17476-8. Epub 2026 Feb 9. PMID- 41660759 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260925 IS - 1557-0657 (Electronic) IS - 1049-8931 (Print) IS - 1049-8931 (Linking) VI - 35 IP - 1 DP - 2026 Mar TI - 'Digital Insight and Agency Scale' (DIAS): A Novel Tool to Illuminate Young People's Agency in Mitigating the Negative Impact of Digital Activities on Their Mental Health. PG - e70053 LID - 10.1002/mpr.70053 [doi] LID - e70053 AB - OBJECTIVES: Excessive time spent online is believed to negatively impact youth mental health; however, simplified screen-time measures fail to consider young people's agency and digital activity management skills. We developed and validated a novel tool, the Digital Insight and Agency Scale (DIAS), to better understand different aspects of young people's online agency and explore their links to youth mental health. METHODS: Participants (n = 383; age 16-25 years, mean = 19.0, SD = 1.7; 48.8% White, 30.2% South/East Asian, 8.6% Black) completed the DIAS questionnaire and standardised measures of anxiety, depression and wellbeing. The factor structure, reliability of the DIAS and associations with mental health were examined. RESULTS: Participants reported specific negative impacts of digital engagement on their daily functioning in the previous 2 weeks, especially less sleep. Seventy-eight per cent were worried about the negative impact of digital activity, and 82% engaged in one or more risk management actions, including Enhancing Positive Engagement, Coping Actions, and/or Reducing Engagement. Higher levels of mental health problems were associated with more worries and increased efforts to manage digital activity. CONCLUSIONS: Most young people displayed agency in managing their digital activity, suggesting that this could be leveraged in interventions, rather than focusing solely on reducing access and time spent online. CI - (c) 2026 The Author(s). International Journal of Methods in Psychiatric Research published by John Wiley & Sons Ltd. FAU - Tang, P AU - Tang P AD - Department of Psychology, School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK. AD - Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. FAU - Kostyrka-Allchorne, K AU - Kostyrka-Allchorne K AD - Department of Psychology, School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK. FAU - Bourgaize, J AU - Bourgaize J AD - Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. AD - Clinical Outcome Solutions, Folkestone, UK. FAU - Murray, A AU - Murray A AD - School of Psychology, University of Edinburgh, Edinburgh, UK. FAU - Stoilova, M AU - Stoilova M AD - Department of Media and Communications, London School of Economics and Political Science, London, UK. FAU - Etherson, M E AU - Etherson ME AD - School of Health and Wellbeing, University of Glasgow, Glasgow, UK. FAU - Azeri, E AU - Azeri E AD - Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. FAU - Abbas, I AU - Abbas I AD - Department of Psychology, School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK. FAU - Bridgwood, A AU - Bridgwood A AD - East London NHS Foundation Trust, London, UK. FAU - Hollis, C AU - Hollis C AD - National Institute of Health Research (NIHR) MindTech MedTech Research Centre, Institute of Mental Health, School of Medicine, University of Nottingham, Nottingham, UK. FAU - Townsend, E AU - Townsend E AD - School of Psychology, University of Nottingham, Nottingham, UK. FAU - Livingstone, S AU - Livingstone S AD - Department of Media and Communications, London School of Economics and Political Science, London, UK. FAU - Sonuga-Barke, E J S AU - Sonuga-Barke EJS AD - Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. CN - Digital Youth Research Programme LA - eng GR - MR/W002450/1/UK Research and Innovation/ PT - Journal Article PL - United States TA - Int J Methods Psychiatr Res JT - International journal of methods in psychiatric research JID - 9111433 SB - IM MH - Humans MH - Adolescent MH - Female MH - Young Adult MH - Male MH - Digital Media MH - Sense of Agency MH - Adult MH - *Psychometrics/instrumentation/standards MH - *Anxiety/diagnosis MH - *Depression/diagnosis MH - *Mental Health MH - Reproducibility of Results PMC - PMC12884440 OTO - NOTNLM OT - adolescence OT - agency OT - anxiety OT - coping OT - depression OT - digital risk perception and management COIS- The authors declare no conflicts of interest. EDAT- 2026/02/09 12:53 MHDA- 2026/02/09 12:54 PMCR- 2026/02/09 CRDT- 2026/02/09 07:13 PHST- 2025/12/15 00:00 [revised] PHST- 2025/10/16 00:00 [received] PHST- 2025/12/30 00:00 [accepted] PHST- 2026/02/09 12:54 [medline] PHST- 2026/02/09 12:53 [pubmed] PHST- 2026/02/09 07:13 [entrez] PHST- 2026/02/09 00:00 [pmc-release] AID - MPR70053 [pii] AID - 10.1002/mpr.70053 [doi] PST - ppublish SO - Int J Methods Psychiatr Res. 2026 Mar;35(1):e70053. doi: 10.1002/mpr.70053. PMID- 41660094 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Comparison of the performance of a Three-Dimensional Body Scanner and radiography in evaluating adult scoliosis. PG - e20752 LID - 10.7717/peerj.20752 [doi] LID - e20752 AB - BACKGROUND: Adult scoliosis, which is characterized by a persistent lateral deviation of the spine of at least 10 degrees in the frontal plane along with vertebral rotation in adulthood, can result from various causes, including degenerative changes, untreated childhood scoliosis, spinal trauma, and prior surgeries. Traditionally, spinal curvature is assessed by measuring the Cobb angle via radiographic imaging; however, concerns over radiation exposure have prompted exploration of alternative diagnostic tools.This study aims to evaluate the effectiveness of a newly developed three-dimensional (3D) body scanner, equipped with 12 depth cameras, in assessing spinal alignment and measuring the Cobb angle in patients with adult scoliosis, in comparison with radiographic imaging. METHODS: In this prospective cohort study, 40 patients with adult scoliosis-both idiopathic and degenerative-underwent evaluation using both radiographic imaging and 3D body scanning. Cobb angles were measured by both methods. Pearson and Spearman's rank correlation coefficients were calculated to assess the linear and monotonic relationships between measurements. Measurement accuracy was quantified using the mean bias from Bland-Altman analysis and spatial agreement of spinal positions was further evaluated using the Intersection over Union (IoU) metric. Univariable and multivariable regression analyses were performed to assess whether body habitus (body mass index, waist circumference, waist-to-height ratio, age, and sex) influenced the absolute error between 3D body scanner-predicted and radiographic Cobb angles. RESULTS: Cobb angle measurements obtained from 3D body scanning were highly correlated with those from radiography (Pearson r = 0.92, P < 0.001; Spearman rho = 0.85, P < 0.001), indicating strong linear and monotonic agreement. Bland-Altman analysis showed a small mean bias of -1.06 (95% limits of agreement: -10.25 to 8.12). The average IoU was 0.89, indicating substantial spatial agreement in spinal position predictions. Importantly, obesity indices (body mass index, waist circumference, waist-to-height ratio) were not significantly associated with the absolute error between 3D body scanner-predicted and radiographic Cobb angles in either univariable or multivariable analyses. CONCLUSIONS: The 3D body scanner exhibits promise for assessing spinal alignment and measuring the Cobb angle in patients with adult scoliosis, offering a reliable alternative to traditional radiographic methods. Its accuracy was not affected by obesity-related indices, supporting its applicability across diverse patient body types. Future research should focus on refining scanning protocols and integrating patient-reported outcomes to enhance clinical utility. CI - (c)2026 Kuo et al. FAU - Kuo, Ting-Ju AU - Kuo TJ AD - Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, New Taipei City, Taiwan. AD - Taipei Neuroscience Institute, Taipei Medical University, Taipei, Taiwan. FAU - Yu, Chin-Yin AU - Yu CY AD - Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, New Taipei City, Taiwan. FAU - Lin, Jui-Chi AU - Lin JC AD - Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, New Taipei City, Taiwan. FAU - Lin, Chien-Min AU - Lin CM AD - Taipei Neuroscience Institute, Taipei Medical University, Taipei, Taiwan. AD - Department of Neurological Surgery, Shuang Ho Hospital, New Taipei City, Taiwan. AD - Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. FAU - Liou, Tsan-Hon AU - Liou TH AD - Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. AD - Department of Physical Medicine and Rehabilitation, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. FAU - Peng, Chih-Wei AU - Peng CW AD - Biomedical Engineering, Taipei Medical University, Taipei, Taiwan. AD - School of Gerontology Health Management, College of Nursing, Taipei Medical University, Taipei, Taiwan. FAU - Chen, Hung-Chou AU - Chen HC AD - Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, New Taipei City, Taiwan. AD - Taipei Neuroscience Institute, Taipei Medical University, Taipei, Taiwan. AD - Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. AD - Center for Evidence-Based Health Care, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260203 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - *Scoliosis/diagnostic imaging MH - *Imaging, Three-Dimensional/instrumentation/methods MH - Female MH - Prospective Studies MH - Adult MH - Male MH - Middle Aged MH - *Radiography/methods MH - Aged MH - Spine/diagnostic imaging PMC - PMC12880093 OTO - NOTNLM OT - 3D body scanner OT - Cobb angle OT - Scoliosis OT - Surface topography COIS- The authors declare there are no competing interests. EDAT- 2026/02/09 12:54 MHDA- 2026/02/09 12:55 PMCR- 2026/02/03 CRDT- 2026/02/09 06:58 PHST- 2025/07/15 00:00 [received] PHST- 2025/12/16 00:00 [accepted] PHST- 2026/02/09 12:55 [medline] PHST- 2026/02/09 12:54 [pubmed] PHST- 2026/02/09 06:58 [entrez] PHST- 2026/02/03 00:00 [pmc-release] AID - 20752 [pii] AID - 10.7717/peerj.20752 [doi] PST - epublish SO - PeerJ. 2026 Feb 3;14:e20752. doi: 10.7717/peerj.20752. eCollection 2026. PMID- 41660067 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Exploring the mediating role of physical activity levels in the relationship between physical literacy and physical fitness in Chinese university students. PG - e20689 LID - 10.7717/peerj.20689 [doi] LID - e20689 AB - OBJECTIVE: This study investigated the relationships between physical literacy (PL), physical activity levels (PALs), and physical fitness among Chinese university students, with a particular focus on the mediating role of PALs and the consistency of findings across various analytical methods. METHODS: Participants included 115 first-year students (79 males, 36 females) from Nanjing, China. PL was assessed using the Perceived Physical Literacy Instrument (PPLI-SC), PALs were measured using the Physical Activity Questionnaire for Adolescents (PAQ-A), and physical fitness was assessed through four indicators: body mass index (BMI), 50-m sprint, sit-and-reach, and 800/1,000-m run. Descriptive statistics, correlation, and regression analyses were conducted in SPSS 26.0. Mediation was tested using the PROCESS macro (Model 4, 5,000 bootstrap samples), and structural equation modeling (SEM) was applied using AMOS 26.0 for validation. RESULTS: Males outperformed females in the 50-m sprint, while females exhibited superior flexibility and cardiorespiratory endurance; BMI was significantly higher in males (p < 0.01). PL was positively correlated with PALs (r = 0.584, p < 0.01), and both were significantly associated with all fitness indicators except BMI. Mediation analyses indicated that PALs fully mediated the associations between PL and sprint performance, flexibility, and cardiorespiratory endurance. For BMI, the PROCESS macro suggested a weak indirect effect, whereas SEM results were nonsignificant, highlighting the sensitivity of the results to the analytical method used. CONCLUSION: PL is strongly linked to physical fitness in Chinese university students, with PALs acting as a critical mediator. The inconsistent BMI findings underscore its complex determinants, which extend beyond physical activity. Promoting PL and PALs through university physical education programs may improve fitness outcomes. Future research should validate these findings using larger samples, longitudinal designs, and broader body composition indicators (e.g., body fat percentage, muscle mass). CI - (c)2026 Sun and Hu. FAU - Sun, Yingshuang AU - Sun Y AD - Department of Physical Education, Suzhou Institute of Industrial Technology, Suzhou, China. FAU - Hu, Donglin AU - Hu D AD - College of Sports Industry and Leisure, Nanjing Sport Institute, Nanjing, Jiangsu Province, China. AD - Department of Physical Education, Nanjing Agricultural University, Nanjing, Jiangsu Province, China. AD - School of Physical Education and Educational Science, Tianjin University of Sport, Tianjin, China. LA - eng PT - Journal Article DEP - 20260203 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - Male MH - Female MH - *Physical Fitness/physiology MH - *Students/statistics & numerical data MH - China MH - Universities MH - *Exercise MH - Adolescent MH - Body Mass Index MH - Young Adult MH - Surveys and Questionnaires MH - *Health Literacy PMC - PMC12880097 OTO - NOTNLM OT - Mediation OT - Physical activity OT - Physical fitness OT - Physical literacy OT - University students COIS- The authors declare there are no competing interests. EDAT- 2026/02/09 12:54 MHDA- 2026/02/09 12:55 PMCR- 2026/02/03 CRDT- 2026/02/09 06:58 PHST- 2025/10/09 00:00 [received] PHST- 2025/12/08 00:00 [accepted] PHST- 2026/02/09 12:55 [medline] PHST- 2026/02/09 12:54 [pubmed] PHST- 2026/02/09 06:58 [entrez] PHST- 2026/02/03 00:00 [pmc-release] AID - 20689 [pii] AID - 10.7717/peerj.20689 [doi] PST - epublish SO - PeerJ. 2026 Feb 3;14:e20689. doi: 10.7717/peerj.20689. eCollection 2026. PMID- 41660063 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260209 LR - 20260211 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 7 DP - 2025 TI - Development of the physical education knowledge questionnaire-Spain (PEKQ-S): feasibility, validity and reliability for Spanish children aged 6-12 years. PG - 1737905 LID - 10.3389/fspor.2025.1737905 [doi] LID - 1737905 AB - PURPOSE: Physical literacy (PL) encompasses the motivation, confidence, physical competence, and knowledge necessary for engaging in physical activity throughout one's life. Although tools such as the Canadian Assessment Physical Literacy (CAPL-2) assess PL globally, they lack cultural alignment with the Spanish context in terms of their cognitive components. This emphasizes the importance of developing a context-specific tool for assessing PL-related knowledge in Spanish primary education. This study aims to develop and validate the Physical Education Knowledge Questionnaire-Spain (PEKQ-S) for children aged 6-12, aligning it with the national physical education (PE) curriculum and evaluating its factor structure and reliability. METHODS: The PEKQ-S was developed through curriculum review, expert consultation, and student input via open-ended and closed-ended questions. Its feasibility and reliability were tested in 145 Spanish primary school children aged 6-12, and its structure was evaluated via exploratory factor analysis. RESULTS: Exploratory factor analysis identified two correlated factors across nine items. The PEKQ-S showed acceptable internal consistency [Cronbach's alpha (alpha) = 0.508-0.832] and fair to substantial test-retest reliability [intra-class correlation coefficient (ICC) = 0.337-0.696]. Moderate correlations were found between factors (r = 0.362), and most items demonstrated good reproducibility and stability. CONCLUSION: The PEKQ-S is a valid, reliable, and feasible tool for assessing PE-related knowledge linked to the PL in Spanish children aged 6-12. It represents the first instrument of its kind in Spain and forms part of the Spanish Physical Literacy Assessment for Children (SPLA-C) model. CI - (c) 2026 Pastor-Cisneros, Mendoza-Munoz, Lopez-Gil and Carlos-Vivas. FAU - Pastor-Cisneros, Raquel AU - Pastor-Cisneros R AD - Physical Activity for Education, Performance and Health (PAEPH) Research Group, Faculty of Sport Sciences, University of Extremadura, Caceres, Spain. FAU - Mendoza-Munoz, Maria AU - Mendoza-Munoz M AD - Department of Communication and Education, Universidad Loyola Andalucia, Sevilla, Spain. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AD - School of Medicine, Universidad Espiritu Santo, Samborondon, Ecuador. AD - Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno, Chile. FAU - Carlos-Vivas, Jorge AU - Carlos-Vivas J AD - Physical Activity for Education, Performance and Health (PAEPH) Research Group, Faculty of Sport Sciences, University of Extremadura, Caceres, Spain. LA - eng PT - Journal Article DEP - 20260123 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC12876181 OTO - NOTNLM OT - SPLA-C OT - assessment OT - physical activity OT - physical literacy OT - validation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/09 12:53 MHDA- 2026/02/09 12:54 PMCR- 2026/01/23 CRDT- 2026/02/09 06:57 PHST- 2025/11/02 00:00 [received] PHST- 2025/12/29 00:00 [revised] PHST- 2025/12/30 00:00 [accepted] PHST- 2026/02/09 12:54 [medline] PHST- 2026/02/09 12:53 [pubmed] PHST- 2026/02/09 06:57 [entrez] PHST- 2026/01/23 00:00 [pmc-release] AID - 10.3389/fspor.2025.1737905 [doi] PST - epublish SO - Front Sports Act Living. 2026 Jan 23;7:1737905. doi: 10.3389/fspor.2025.1737905. eCollection 2025. PMID- 41657688 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Direct and indirect effects of physical exercise on life satisfaction and quality of life in Chinese adolescents during the COVID-19 pandemic. PG - 1692392 LID - 10.3389/fpubh.2026.1692392 [doi] LID - 1692392 AB - BACKGROUND: The COVID-19 pandemic exacerbated mental health challenges among adolescents, yet the protective role of regular physical exercise (PE) in enhancing life satisfaction (LS) and quality of life (QOL) remains underexplored in this population. This study aimed to investigate the direct and indirect effects of PE on LS and QOL among Chinese adolescents during the pandemic, with a focus on its mediating pathways through alleviating depressive and anxious symptoms. METHODS: Adolescents aged 12 to 17 seeking for psychological services at Shandong Provincial Hospital were recruited between June 2021 and May 2022. Using the Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), 6-items QOL questionnaire (QOL-6), and Adolescent Students' Life Satisfaction Scale (ASLSS), we assessed depressive symptoms, anxious symptoms, QOL, and LS. RESULTS: A total of 392 adolescents (133 regular physical exercisers (PEs) vs. 259 non-regular physical exercisers (NPEs)) were included. Significant differences were observed in educational level, residence, general health status, and regular diet between PE and NPEs. A one-way ANOVA showed that PEs had significantly lower scores on GAD-7 and PHQ-9, higher QOL-6 scores, and greater LS across all six ASLSS dimensions compared to NPEs. The mediation analysis showed regular exercise indirect positive effects on QOL-6 and ASLSS 6 dimensions through the alleviation of anxious and depressive symptoms. Stepwise regression confirmed the significant positive effect of exercise on QOL, as well as LS with friendship, academic performance, and autonomy. CONCLUSION: PE alleviates emotional distress and enhances subjective well-being in adolescents through dual pathways, underscoring its value as a low-cost intervention during public health crises. Findings advocate integrating structured physical activity into school-based mental health programs to foster resilience. Longitudinal studies are needed to validate causal mechanisms and optimize exercise protocols for diverse adolescent populations. CI - Copyright (c) 2026 Dou, Ma, Qi, Ren, Zhao and Sun. FAU - Dou, Liqiang AU - Dou L AD - Department of Psychiatry, Qingdao University Medical College, Qingdao, China. AD - Department of Psychiatry, Pingdu Mental Health Center, Qingdao, China. FAU - Ma, Mi AU - Ma M AD - Department of Psychiatry, Qingdao University Medical College, Qingdao, China. AD - Department of Psychiatry, Qingdao Mental Health Center, Shandong, China. FAU - Qi, Wenbo AU - Qi W AD - Department of Psychiatry, Qingdao University Medical College, Qingdao, China. AD - Department of Psychiatry, Qingdao Mental Health Center, Shandong, China. FAU - Ren, Honghong AU - Ren H AD - Department of Psychology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. FAU - Zhao, Guoqing AU - Zhao G AD - Department of Psychology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. FAU - Sun, Ping AU - Sun P AD - Department of Psychiatry, Qingdao University Medical College, Qingdao, China. AD - Department of Psychiatry, Qingdao Mental Health Center, Shandong, China. LA - eng PT - Journal Article DEP - 20260122 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - Chinese people SB - IM MH - Humans MH - Adolescent MH - *Quality of Life/psychology MH - *COVID-19/epidemiology/psychology MH - *Exercise/psychology MH - Female MH - Male MH - China/epidemiology MH - *Personal Satisfaction MH - Depression/epidemiology MH - Anxiety/epidemiology MH - Child MH - Surveys and Questionnaires MH - Mental Health MH - East Asian People PMC - PMC12872919 OTO - NOTNLM OT - adolescents OT - anxious symptoms OT - depressive symptoms OT - life satisfaction OT - physical exercise OT - quality of life COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/09 12:54 MHDA- 2026/02/09 12:55 PMCR- 2026/01/22 CRDT- 2026/02/09 06:37 PHST- 2025/08/25 00:00 [received] PHST- 2025/12/19 00:00 [revised] PHST- 2026/01/05 00:00 [accepted] PHST- 2026/02/09 12:55 [medline] PHST- 2026/02/09 12:54 [pubmed] PHST- 2026/02/09 06:37 [entrez] PHST- 2026/01/22 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1692392 [doi] PST - epublish SO - Front Public Health. 2026 Jan 22;14:1692392. doi: 10.3389/fpubh.2026.1692392. eCollection 2026. PMID- 41656733 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 1941-2444 (Electronic) IS - 0148-6071 (Print) IS - 0148-6071 (Linking) VI - 50 IP - 4 DP - 2026 May TI - Performance of different nutrition risk screening tools in predicting malnutrition in critically ill children on mechanical ventilation: A comparison study. PG - 507-514 LID - 10.1002/jpen.70064 [doi] AB - BACKGROUND: This study aimed to characterize the distribution of nutrition status and nutrition risk stratification in critically ill children undergoing mechanical ventilation and to evaluate the association of nutrition risk with their clinical outcomes. METHODS: This comparison study included 375 critically ill children receiving mechanical ventilation (invasive or noninvasive, duration >/=24 h). Nutrition status at admission was evaluated using body mass index z score, and nutrition risk was assessed via three validated tools: Paediatric Yorkhill Malnutrition Score (PYMS), Screening Tool for the Assessment of Malnutrition in Pediatrics (STAMP), and Screening Tool for Risk on Nutritional Status and Growth (STRONGkids). Clinical data were extracted from electronic records. RESULTS: Three hundred seventy-five critically ill children undergoing mechanical ventilation were enrolled (207 boys, 168 girls; median age, 8 [2-26.5] months), with 246 receiving invasive and 129 noninvasive ventilation; 20.6% had moderate-severe malnutrition (59.7% in invasive ventilation). All tools identified >60% at high risk. STRONGkids (area under the curve [AUC], 0.90) and PYMS (AUC, 0.86) better predicted malnutrition than STAMP (AUC, 0.74). STRONGkids (AUC, 0.89) outperformed in mortality prediction. Higher risk correlated with longer ventilation/pediatric intensive care unit stay, higher costs, and worse outcomes (P < 0.05). Multivariate analysis showed malnutrition, clinical diagnosis, and lactate level as independent risk factors and no organ dysfunction, healthy serum prealbumin level, and healthy serum albumin level as protective factors. CONCLUSION: PYMS and STRONGkids demonstrated high predictive value for moderate-to-severe malnutrition and mortality in children undergoing mechanical ventilation. CI - (c) 2026 The Author(s). Journal of Parenteral and Enteral Nutrition published by Wiley Periodicals LLC on behalf of American Society for Parenteral and Enteral Nutrition. FAU - Li, Ning AU - Li N AUID- ORCID: 0009-0002-9004-6354 AD - Department of Critical Care Medicine, Capital Institute of Pediatrics, Capital Center for Children's Health, Capital Medical University, Beijing, China. AD - Department of Critical Care Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Capital Center for Children's Health, Capital Medical University, Beijing, China. FAU - Chen, Jing AU - Chen J AD - Department of Critical Care Medicine, Capital Institute of Pediatrics, Capital Center for Children's Health, Capital Medical University, Beijing, China. FAU - Lu, Xiuxiu AU - Lu X AD - Department of Critical Care Medicine, Capital Institute of Pediatrics, Capital Center for Children's Health, Capital Medical University, Beijing, China. FAU - Li, Wei AU - Li W AD - Department of Critical Care Medicine, Capital Institute of Pediatrics, Capital Center for Children's Health, Capital Medical University, Beijing, China. FAU - Qu, Dong AU - Qu D AD - Department of Critical Care Medicine, Capital Institute of Pediatrics, Capital Center for Children's Health, Capital Medical University, Beijing, China. FAU - Liu, Shuang AU - Liu S AD - Department of Critical Care Medicine, Capital Institute of Pediatrics, Capital Center for Children's Health, Capital Medical University, Beijing, China. FAU - Wang, Lin AU - Wang L AD - Capital Institute of Pediatrics, Center of Children's Healthcare, Capital Center for Children's Health, Capital Medical University, Beijing, China. AD - Center of Children's Healthcare, Capital Center for Children's Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Capital Medical University, Beijing, China. LA - eng GR - 82273645/National Natural Science Foundation of China/ GR - L232121/Beijing Natural Science Foundation Haidian Original Innovation Joint Fund/ GR - 2024-1-1131/Capital's Funds for Health Improvement and Research/ GR - 7232235/Beijing Natural Science Foundation/ PT - Comparative Study PT - Journal Article DEP - 20260208 PL - United States TA - JPEN J Parenter Enteral Nutr JT - JPEN. Journal of parenteral and enteral nutrition JID - 7804134 SB - IM MH - Humans MH - *Respiration, Artificial/adverse effects MH - Female MH - *Critical Illness/therapy MH - Male MH - Child, Preschool MH - *Nutrition Assessment MH - *Malnutrition/diagnosis/etiology MH - Infant MH - *Nutritional Status MH - Risk Assessment/methods MH - Risk Factors MH - Body Mass Index MH - Length of Stay MH - Intensive Care Units, Pediatric MH - Area Under Curve PMC - PMC13169076 OTO - NOTNLM OT - children OT - critically ill OT - mechanical ventilation OT - nutrition risk OT - nutrition status COIS- None declared. EDAT- 2026/02/09 06:29 MHDA- 2026/05/13 12:32 PMCR- 2026/05/13 CRDT- 2026/02/09 01:34 PHST- 2026/01/17 00:00 [revised] PHST- 2025/04/09 00:00 [received] PHST- 2026/01/20 00:00 [accepted] PHST- 2026/05/13 12:32 [medline] PHST- 2026/02/09 06:29 [pubmed] PHST- 2026/02/09 01:34 [entrez] PHST- 2026/05/13 00:00 [pmc-release] AID - JPEN70064 [pii] AID - 10.1002/jpen.70064 [doi] PST - ppublish SO - JPEN J Parenter Enteral Nutr. 2026 May;50(4):507-514. doi: 10.1002/jpen.70064. Epub 2026 Feb 8. PMID- 41653378 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20261009 IS - 1573-2649 (Electronic) IS - 0962-9343 (Linking) VI - 35 IP - 3 DP - 2026 Feb 7 TI - Psychometric properties comparison of EQ-5D-Y-3L and CHU9D in children and adolescents across different BMI classifications in Jiangsu, China. PG - 65 LID - 10.1007/s11136-026-04168-1 [doi] AB - BACKGROUND: This study aims to assess and compare the psychometric properties of EQ-5D-Y-3L and CHU9D in children and adolescents across different BMI classifications in Jiangsu, China. And to identify the more appropriate tool for BMI-related health related quality of life (HRQoL) assessment. METHODS: A multi-stage stratified random sampling approach was employed among children and adolescents aged 9 to 17 in Jiangsu Province. The feasibility, construct validity (including convergent, discriminant, and known-group validity) and ability to detect changes of these instruments were evaluated. Random forest models and restricted cubic spline analyses were utilized to examine factors associated with HRQoL. RESULTS: A survey of 37,574 participants (mean age: 13.53 years; 51.6% males) yielded complete data. The EQ-5D-Y-3L showed a higher ceiling effect (70.0%) than CHU9D (42.2%). Utility values for both instruments were highly correlated (r = 0.64), and the intraclass correlation coefficient (ICC) between the two utility values was 0.637. Moderate-to-high correlations were found in conceptually similar dimensions (r = 0.41-0.58, p < 0.001). Significant differences were observed in the two utility values and EQ-VAS across different BMI classifications (p < 0.001), with the CHU9D utility values and EQ-VAS demonstrating higher relative efficiency (RE > 1) and effect sizes (0.038-0.218) compared to EQ-5D-Y-3L utility values (0.044-0.104). Age, gender, BMI, boarding at school, and parents' education were significantly related to HRQoL (p < 0.05). CONCLUSIONS: Both EQ-5D-Y-3L and CHU9D show acceptable psychometric properties in Chinese children and adolescents, while utility values are not interchangeable. The CHU9D is recommended due to its superior ability to detecting changes and lower ceiling effect. Further study on the psychometric properties of EQ-VAS is needed. FAU - Liang, Junyan AU - Liang J AD - School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, China. AD - Chengdu Center for Disease Control and Prevention, Chengdu Institute of Health Supervision, 610041, Chengdu, China. FAU - Dong, Huibin AU - Dong H AD - Section of School Health, Changzhou Center for Disease Control and Prevention, Changzhou, 213022, China. FAU - Yang, Juan AU - Yang J AD - Section of School Health, Huai'an Center for Disease Control and Prevention, Huai'an, 223001, China. FAU - Xu, Xinpeng AU - Xu X AD - School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, China. FAU - Wu, Qifeng AU - Wu Q AD - School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, China. FAU - Gu, Minjia AU - Gu M AD - Nanjing Foreign Language School Xianlin Campus, Nanjing, 210003, China. FAU - Yi, Honggang AU - Yi H AD - School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, China. FAU - Liu, Li AU - Liu L AD - Section of School Health, Nanjing Center for Disease Control and Prevention, Nanjing, 210003, China. s042324l@126.com. FAU - You, Hua AU - You H AD - School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, China. youhua98@163.com. AD - Laboratory for Digital Intelligence and Health Governance, Nanjing Medical University, Nanjing, 211166, China. youhua98@163.com. LA - eng GR - QY202408/Science and Technology Project of Changzhou municipal health commission/ GR - 72074122/the National Natural Science Foundation of China/ PT - Comparative Study PT - Journal Article DEP - 20260207 PL - Netherlands TA - Qual Life Res JT - Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation JID - 9210257 SB - IM MH - Humans MH - *Psychometrics MH - Adolescent MH - Female MH - Child MH - Male MH - *Quality of Life/psychology MH - China MH - *Body Mass Index MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Health Status OTO - NOTNLM OT - Body mass index OT - CHU9D OT - China OT - EQ-5D-Y-3L OT - Health-related quality of life OT - Psychometric property OT - Reliability OT - Validity COIS- Declarations. Competing interests: The authors declare that they have no competing interests. Ethics approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Ethical Review Committee of Nanjing Medical University (Ethics approval number: ((2021) 661). Consent to participate: Verbal informed consent was obtained from all individual participants and their legal guardians. Consent for publication: The authors affirm that human research participants provided informed consent for publication of the information in all tables and figures. EDAT- 2026/02/07 12:52 MHDA- 2026/06/27 18:37 CRDT- 2026/02/07 11:16 PHST- 2025/10/21 00:00 [received] PHST- 2026/01/07 00:00 [accepted] PHST- 2026/06/27 18:37 [medline] PHST- 2026/02/07 12:52 [pubmed] PHST- 2026/02/07 11:16 [entrez] AID - 10.1007/s11136-026-04168-1 [pii] AID - 10.1007/s11136-026-04168-1 [doi] PST - epublish SO - Qual Life Res. 2026 Feb 7;35(3):65. doi: 10.1007/s11136-026-04168-1. PMID- 41652667 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 1098-108X (Electronic) IS - 0276-3478 (Print) IS - 0276-3478 (Linking) VI - 59 IP - 5 DP - 2026 May TI - Multivariate Trajectories of Eating Disorder Symptoms and Weight Status in 10- to 17-Year-Old Children and Adolescents. PG - 978-995 LID - 10.1002/eat.70045 [doi] AB - OBJECTIVE: Eating disorders (EDs) often emerge in adolescence, but developmental trajectories across different core features remain largely unclear. METHOD: The prospective, community-based study included N = 898 participants aged 9.5-17.5 years (47.6% female, age 11.8 +/- 1.4 years) with annual follow-up over 2-6 (3.4 +/- 1.2) years. Multivariate trajectories of binge eating, restraint, weight-compensatory behaviors (Eating Disorder Examination-Questionnaire for Children), and body mass index-standard deviation score (BMI-SDS) derived from objective anthropometrics were analyzed using group-based multi-trajectory modeling (GBMTM) separately for girls and boys. ED and general psychopathology were used for validation and outcome comparisons. RESULTS: GBMTM identified five distinct trajectories of ED symptoms and BMI-SDS in girls and six in boys. Low-symptom trajectories at lower, normal, and higher BMI-SDS were most common and showed only mild, transient ED symptoms. In boys, trajectories were largely characterized by stable ED symptoms at different BMI-SDS levels, whereas in girls, ED symptoms showed more pronounced change over time. In both sexes, two high-risk subgroups reflected bulimic and binge-eating patterns and followed trajectories with elevated or increasing ED symptoms across ages, which in girls were particularly associated with increased ED and general psychopathology at last assessment. DISCUSSION: GBMTM results support the developmental specificity of bulimic/binge-eating syndromes and noneating-disordered overweight across adolescence. High-risk subgroups in both sexes-and their particularly unfavorable outcomes in girls-underscore the need for sex-specific early identification strategies that consider longitudinal constellations of multiple ED symptoms and weight status rather than single indicators. CI - (c) 2026 The Author(s). International Journal of Eating Disorders published by Wiley Periodicals LLC. FAU - Hilbert, Anja AU - Hilbert A AUID- ORCID: 0000-0003-2775-1296 AD - Integrated Research and Treatment Center AdiposityDiseases, Behavioral Medicine Research Unit, Department of Psychosomatic Medicine and Psychotherapy, Leipzig University Medical Center, Leipzig, Germany. AD - German Center for Child and Adolescent Health (DZKJ), partner site Leipzig/Dresden, Leipzig, Germany. FAU - Schewe, Danielle AU - Schewe D AUID- ORCID: 0009-0006-7237-1945 AD - Integrated Research and Treatment Center AdiposityDiseases, Behavioral Medicine Research Unit, Department of Psychosomatic Medicine and Psychotherapy, Leipzig University Medical Center, Leipzig, Germany. FAU - Hiemisch, Andreas AU - Hiemisch A AUID- ORCID: 0000-0001-6851-1307 AD - LIFE Leipzig Research Center for Civilization Diseases, Leipzig University, Leipzig, Germany. AD - Department of Women and Child Health, University Hospital for Children and Adolescents and Center for Pediatric Research, Leipzig University, Leipzig, Germany. FAU - Korner, Antje AU - Korner A AUID- ORCID: 0000-0001-6001-0356 AD - German Center for Child and Adolescent Health (DZKJ), partner site Leipzig/Dresden, Leipzig, Germany. AD - LIFE Leipzig Research Center for Civilization Diseases, Leipzig University, Leipzig, Germany. AD - Department of Women and Child Health, University Hospital for Children and Adolescents and Center for Pediatric Research, Leipzig University, Leipzig, Germany. FAU - Kiess, Wieland AU - Kiess W AUID- ORCID: 0000-0003-4118-9455 AD - German Center for Child and Adolescent Health (DZKJ), partner site Leipzig/Dresden, Leipzig, Germany. AD - LIFE Leipzig Research Center for Civilization Diseases, Leipzig University, Leipzig, Germany. AD - Department of Women and Child Health, University Hospital for Children and Adolescents and Center for Pediatric Research, Leipzig University, Leipzig, Germany. FAU - Schmidt, Ricarda AU - Schmidt R AUID- ORCID: 0000-0001-7794-2897 AD - Integrated Research and Treatment Center AdiposityDiseases, Behavioral Medicine Research Unit, Department of Psychosomatic Medicine and Psychotherapy, Leipzig University Medical Center, Leipzig, Germany. AD - German Center for Child and Adolescent Health (DZKJ), partner site Leipzig/Dresden, Leipzig, Germany. LA - eng GR - Leipzig Research Center for Civilization Diseases (LIFE)/ GR - Leipzig University/ GR - European Union/ GR - European Social Fund/ GR - European Regional Development Fund/ GR - Freistaat Sachsen/ PT - Journal Article DEP - 20260206 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM MH - Humans MH - Child MH - Female MH - *Feeding and Eating Disorders/psychology/diagnosis MH - Adolescent MH - Male MH - Body Mass Index MH - Prospective Studies MH - *Body Weight PMC - PMC13147146 OTO - NOTNLM OT - binge eating OT - body mass index OT - compensatory behavior OT - development OT - eating disorder OT - latent structure analysis OT - obesity OT - restraint OT - trajectory COIS- During the preparation of this work the authors used ChatGPT (OpenAI, version 5.0 and 5.1) and DeepL (DeepL SE) in order to improve the readability and language of the manuscript. After using this tool, the authors reviewed and edited the content as needed and took full responsibility for the content of the published article. Dr. Hilbert reports receiving research grants from the German Federal Ministry of Education and Research, German Research Foundation, Innovation Fund, and Roland Ernst Foundation for Health Care; royalties for books on the treatment of eating disorders and obesity with Hogrefe and Kohlhammer; honoraria for workshops and lectures on eating disorders and obesity and their treatment, including from Lilly, Novo Nordisk, and Rhythm Pharmaceuticals; honoraria as editor of the International Journal of Eating Disorders; and honoraria as a consultant for Takeda and Medice. No other conflicts of interest were reported. EDAT- 2026/02/07 06:33 MHDA- 2026/05/06 06:39 PMCR- 2026/05/06 CRDT- 2026/02/07 00:53 PHST- 2026/01/19 00:00 [revised] PHST- 2025/07/24 00:00 [received] PHST- 2026/01/21 00:00 [accepted] PHST- 2026/05/06 06:39 [medline] PHST- 2026/02/07 06:33 [pubmed] PHST- 2026/02/07 00:53 [entrez] PHST- 2026/05/06 00:00 [pmc-release] AID - EAT70045 [pii] AID - 10.1002/eat.70045 [doi] PST - ppublish SO - Int J Eat Disord. 2026 May;59(5):978-995. doi: 10.1002/eat.70045. Epub 2026 Feb 6. PMID- 41652582 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Feb 6 TI - Small intestinal microbiota of undernourished women of reproductive age and microbiota-directed balanced energy protein (MD-BEP) supplementation in maternal environmental enteric dysfunction (EED): protocol for a community-based intervention study. LID - 10.1186/s12884-026-08710-4 [doi] LID - 248 AB - INTRODUCTION: Studies show, malnourished women of childbearing age with environmental enteric dysfunction (EED) exhibit small intestinal enteropathy resembling that in malnourished children residing in the same community. However, currently there are no universally accepted protocols for validation of these facts. Our current protocol is designed to better understand the mechanism of transmission of the microbiota of mothers with EED to their children perpetuates intergenerational undernutrition. We plan to compare the small intestinal (SI) and fecal microbiota along with plasma, duodenal, and fecal proteomes/ metabolomes and histopathologic evidence of EED in non-pregnant women with and without malnutrition. We also plan to see and compare the effect of microbiota-directed balanced energy protein (MD-BEP) supplementation on these biological parameters between malnourished non-pregnant and pregnant women. METHODS AND ANALYSIS: This is a community-based intervention study where pregnant women and non-pregnant women of reproductive age (18-35 years) will be screened through household surveys from the Bauniabadh and adjacent slum area of Mirpur, Dhaka (pregnant and non-pregnant cohorts, n=90 each). Using Body Mass Index (BMI), both the groups will be categorized into undernourished (BMI <18.5kg/m2, n=60 each with pregnant and non-pregnant cohort) and well-nourished (BMI >20-24.9 kg/ m2, n=30, each with pregnant and non-pregnant cohort). Upper gastro-intestinal (UGI) endoscopy will be performed on non-pregnant women (both well-nourished and undernourished cohorts) and biopsy samples will be collected for diagnosis of environmental enteric dysfunction (EED) by histopathological scoring. We will compare the small intestinal (SI) and fecal microbiota and the plasma, duodenal, and fecal proteomes/ metabolomes of the undernourished non-pregnant cohort with histopathologic evidence of EED with the well-nourished non-pregnant cohort with no histopathologic evidence of EED (Aim IA). Furthermore, we will perform an intervention study (Aim IB). The undernourished non-pregnant cohort will be randomized into two groups (n=30/arm) and receive daily dietary supplementation with either shelf-stable microbiota-directed balanced energy protein (MD-BEP) or ready-to -use supplementary food balanced energy protein (RUSF-BEP) for 90 days. After cessation of the intervention they will be further followed up for another 270 days and biological samples will be collected at scheduled time points. The well-nourished non-pregnant cohort will not receive any nutritional intervention will serve as a reference control group. The undernourished pregnant cohort will also be randomly (n=30/arm) assigned to receive either MD-BEP or RUSF-BEP daily for 6 months until the child birth and thereafter for 3 months and followed up for another 9 months. During this period anthropometry will be measured and biological samples including fecal and plasma samples will be collected from the mothers and their infants in scheduled time points. Anthropometric, socio-demographic and laboratory assay data will be compared between the groups and candidate EED biomarkers will be correlated with nutritional status, histological analyses and score of EED, plus assessments of microbial community structure will be examined. ETHICS AND DISSEMINATION: Ethics approval was obtained from the Ethical Review Committee of icddr,b (protocol no: PR-22117; Version 1.2; 29 November 2022). The running approved protocol version is v1.3, dated 07 May 2024. Results of this study will be submitted for publication in peer-reviewed journals. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov ID: NCT05862363. Registered on 08 February 2023. https://clinicaltrials.gov/study/NCT05862363 . FAU - Hossain, Md Shabab AU - Hossain MS AD - Nutrition Research Division (NRD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh. dr.shabab@icddrb.org. FAU - Mahfuz, Mustafa AU - Mahfuz M AD - Nutrition Research Division (NRD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh. FAU - Rahman, M Masudur AU - Rahman MM AD - Department of Gastroenterology, Manikganj Medical College, Dhaka, Bangladesh. AD - Department of Gastrointestinal, Hepatobiliary and Pancreatic Disorders, Bangladesh Specialized Hospital, Dhaka, Bangladesh. FAU - Begum, S M Khodeza Nahar AU - Begum SMKN AD - Department of Histopathology & Cytology, Bangladesh Specialized Hospital, Dhaka, Bangladesh. AD - Department of Pathology, Dr Sirajul Islam Medical College, Dhaka, Bangladesh. FAU - Sarker, Shafiqul Alam AU - Sarker SA AD - Nutrition Research Division (NRD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh. FAU - Ahmed, Tahmeed AU - Ahmed T AD - Office of Executive Director (OED), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh. AD - Department of Global Health, University of Washington, Seattle, WA, United States of America. LA - eng SI - ClinicalTrials.gov/NCT05862363 GR - INV-045337/GATES/Gates Foundation/United States PT - Clinical Trial Protocol PT - Journal Article DEP - 20260206 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 RN - 0 (Dietary Proteins) SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Pregnancy MH - Young Adult MH - *Dietary Proteins/administration & dosage MH - *Dietary Supplements MH - Duodenum/microbiology MH - Feces/microbiology MH - *Gastrointestinal Microbiome MH - *Intestinal Diseases/microbiology MH - *Intestine, Small/microbiology/pathology MH - *Malnutrition/microbiology/complications MH - *Pregnancy Complications/microbiology PMC - PMC12977528 OTO - NOTNLM OT - Environmental enteric dysfunction OT - Gut microbiota OT - Maternal undernutrition OT - Microbiota directed balanced energy protein OT - Pregnancy COIS- Declarations. Ethics approval and consent to participate: Ethical Review Committee of icddr,b (protocol no: PR-22117; Version 1.2; 29 November 2022). The running approved protocol version is v1.3, dated 07 May 2024. Each participant enrolled in the study is treated according to what is morally right and proper. After complete disclosure, a signed written informed consent statement is obtained from each subject. If the subject agrees to participate in the study, they sign the consent form or provide an impression of their thumb. For endoscopy and supplement intervention, a separate consent form is used and the aforementioned procedure is followed. The consent form for endoscopy clearly and fully describes, and demystifies, all aspects of the process, including the risks related with the procedure. No information is remained withheld from the participant. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/07 06:33 MHDA- 2026/06/27 06:45 PMCR- 2026/02/06 CRDT- 2026/02/07 00:09 PHST- 2025/07/22 00:00 [received] PHST- 2026/01/23 00:00 [accepted] PHST- 2026/06/27 06:45 [medline] PHST- 2026/02/07 06:33 [pubmed] PHST- 2026/02/07 00:09 [entrez] PHST- 2026/02/06 00:00 [pmc-release] AID - 10.1186/s12884-026-08710-4 [pii] AID - 8710 [pii] AID - 10.1186/s12884-026-08710-4 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Feb 6;26(1):248. doi: 10.1186/s12884-026-08710-4. PMID- 41652183 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 1476-5497 (Electronic) IS - 0307-0565 (Print) IS - 0307-0565 (Linking) VI - 50 IP - 2 DP - 2026 Feb TI - Sex-dependent associations of childhood maltreatment with obesity-related traits: results from the German National Cohort (NAKO). PG - 329-337 LID - 10.1038/s41366-025-01914-2 [doi] AB - BACKGROUND: The relationship between childhood maltreatment (CM) and obesity is nuanced, and recent evidence suggests stronger associations between CM and obesity-related traits in females compared to males. This study aims to validate and extend these findings in a large sample from the German National Cohort (NAKO). METHODS: The NAKO is a population-based cohort study including 204,744 adults. For the present analyses, 151,143 individuals (74,596 female) were included. CM was assessed using the Childhood Trauma Screener (CTS). From the CTS, an overall severity score (CTS sum score), a cumulative CM score (number of CM subtypes with at least moderate severity), and five CTS subtypes were considered as exposures. Obesity-related traits included anthropometric (height, weight, body mass index [BMI], waist circumference [WC]) and body fat markers (relative fat mass [rFM], subcutaneous [SAT], visceral adipose tissue [VAT]). Sex-stratified linear and logistic regression models were adjusted for age, education, and examination center to associate CTS-based scores with obesity-related traits. RESULTS: Associations of the CTS sum score with weight, BMI, WC, rFM, and SAT were stronger in females compared to males, while similar associations were observed for VAT. In both sexes, most obesity-related traits exhibited dose-response relationships with increasing numbers of CM subtypes. Compared to unexposed females, females with exposure to >/=3 CM subtypes had a higher risk for obesity (i.e., BMI >/= 30 kg/m(2); OR = 1.56; 95% CI: 1.43, 1.71) and high WC (i.e., WC >/= 88 cm; OR = 1.39; 95% CI: 1.29, 1.50). In males, exposure to >/=3 CM subtypes was also associated with increased obesity risk (OR = 1.51; 95% CI: 1.32, 1.72) and high WC (i.e., WC >/= 102 cm; OR = 1.31; 95% CI: 1.18, 1.44). Physical and emotional abuse exhibited the strongest average associations and were associated with the most outcomes. CONCLUSION: Associations of CM exposure with adult anthropometric and body fat markers are stronger in females compared to males. CI - (c) 2026. The Author(s). FAU - Topfer, Philipp AU - Topfer P AUID- ORCID: 0000-0002-0041-6538 AD - Department of Internal Medicine A, University Medicine Greifswald, Greifswald, Germany. Philipp.toepfer@med.uni-greifswald.de. FAU - Klinger-Konig, Johanna AU - Klinger-Konig J AD - Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. FAU - Siewert-Markus, Ulrike AU - Siewert-Markus U AD - Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. FAU - Schipf, Sabine AU - Schipf S AD - Institute for Community Medicine, Department SHIP Clinical-Epidemiological Research, University Medicine Greifswald, Greifswald, Germany. FAU - Fischer, Beate AU - Fischer B AD - Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany. FAU - Sedlmeier, Anja M AU - Sedlmeier AM AD - Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany. AD - Center for Translational Oncology, University Hospital Regensburg, Regensburg, Germany. AD - Bavarian Cancer Research Center (BZKF), Regensburg, Germany. FAU - Hebestreit, Antje AU - Hebestreit A AUID- ORCID: 0000-0001-7354-5958 AD - Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. FAU - Ahrens, Wolfgang AU - Ahrens W AUID- ORCID: 0000-0003-3777-570X AD - Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. FAU - Berger, Klaus AU - Berger K AD - Institute of Epidemiology and Social Medicine, University of Munster, Munster, Germany. FAU - Brenner, Hermann AU - Brenner H AUID- ORCID: 0000-0002-6129-1572 AD - Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. AD - Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumour Diseases (NCT), Heidelberg, Germany. AD - German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. FAU - Do, Stefanie AU - Do S AD - Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. FAU - Heise, Jana-Kristin AU - Heise JK AD - Department of Epidemiology, Helmholtz Center for Infection Research (HZI), Braunschweig, Germany. FAU - Jaskulski, Stefanie AU - Jaskulski S AD - Institute for Prevention and Cancer Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany. FAU - Karch, Andre AU - Karch A AD - Institute of Epidemiology and Social Medicine, University of Munster, Munster, Germany. FAU - Keil, Thomas AU - Keil T AUID- ORCID: 0000-0002-9108-3360 AD - Institute of Social Medicine, Epidemiology and Health Economics, Charite-University Medicine Berlin, Berlin, Germany. AD - Institute for Clinical Epidemiology and Biometry, University of Wurzburg, Wurzburg, Germany. AD - State Institute of Health I, Bavarian State Office for Health and Food Safety, Erlangen, Germany. FAU - Klett-Tammen, Carolina AU - Klett-Tammen C AD - Department of Epidemiology, Helmholtz Center for Infection Research (HZI), Braunschweig, Germany. FAU - Leitzmann, Michael F AU - Leitzmann MF AD - Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany. FAU - Peters, Annette AU - Peters A AUID- ORCID: 0000-0001-6645-0985 AD - Institute of Epidemiology, Helmholtz Zentrum Munchen-German Research Center for Environmental Health (GmbH), Neuherberg, Germany. AD - Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany. AD - German Center for Mental Health (DZPG), Partner Site Munich, Munich, Germany. FAU - Schmidt, Borge AU - Schmidt B AD - Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany. FAU - Schulze, Matthias B AU - Schulze MB AUID- ORCID: 0000-0002-0830-5277 AD - Department of Molecular Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany. AD - Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany. FAU - Willich, Stefan N AU - Willich SN AD - Institute of Social Medicine, Epidemiology and Health Economics, Charite-University Medicine Berlin, Berlin, Germany. FAU - Dorr, Marcus AU - Dorr M AD - Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany. AD - German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany. FAU - Volzke, Henry AU - Volzke H AD - Institute for Community Medicine, Department SHIP Clinical-Epidemiological Research, University Medicine Greifswald, Greifswald, Germany. FAU - Markus, Marcello R P AU - Markus MRP AUID- ORCID: 0000-0002-6234-4955 AD - Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany. AD - German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany. FAU - Stracke, Sylvia AU - Stracke S AD - Department of Internal Medicine A, University Medicine Greifswald, Greifswald, Germany. FAU - Grabe, Hans J AU - Grabe HJ AD - Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. AD - German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany. FAU - Ittermann, Till AU - Ittermann T AD - Institute for Community Medicine, Department SHIP Clinical-Epidemiological Research, University Medicine Greifswald, Greifswald, Germany. LA - eng PT - Journal Article DEP - 20260206 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 SB - IM MH - Humans MH - Female MH - Male MH - Germany/epidemiology MH - *Obesity/epidemiology MH - Cohort Studies MH - Sex Factors MH - Body Mass Index MH - Adult MH - Middle Aged MH - *Child Abuse/statistics & numerical data MH - Child MH - Risk Factors PMC - PMC12913021 COIS- Competing interests: The authors declare no competing interests. Ethical approval: The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008. The NAKO obtained ethics approval from all local committees of the study centers. All participants provided written informed consent. EDAT- 2026/02/07 00:31 MHDA- 2026/02/18 00:49 PMCR- 2026/02/06 CRDT- 2026/02/06 23:32 PHST- 2025/01/30 00:00 [received] PHST- 2025/09/09 00:00 [accepted] PHST- 2025/08/19 00:00 [revised] PHST- 2026/02/18 00:49 [medline] PHST- 2026/02/07 00:31 [pubmed] PHST- 2026/02/06 23:32 [entrez] PHST- 2026/02/06 00:00 [pmc-release] AID - 10.1038/s41366-025-01914-2 [pii] AID - 1914 [pii] AID - 10.1038/s41366-025-01914-2 [doi] PST - ppublish SO - Int J Obes (Lond). 2026 Feb;50(2):329-337. doi: 10.1038/s41366-025-01914-2. Epub 2026 Feb 6. PMID- 41651182 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1938-3207 (Electronic) IS - 0002-9165 (Linking) VI - 123 IP - 4 DP - 2026 Apr TI - Omega-3 PUFA concentrations in childhood prospectively associate with academic performance beyond a healthy diet: findings from the multiethnic Asian Growing Up in Singapore Towards healthy Outcomes cohort study. PG - 101233 LID - S0002-9165(26)00042-0 [pii] LID - 10.1016/j.ajcnut.2026.101233 [doi] AB - BACKGROUND: The influence of plasma DHA and overall omega-3 (n-3) long-chain PUFA (LC-PUFA) on child cognitive development is unclear. OBJECTIVES: We examined if plasma LC-PUFA concentrations are prospectively associated with academic performance in primary school children and if diet patterns modulate the relationship. METHODS: Children were from the Growing Up in Singapore Toward healthy Outcomes cohort. Fasting LC-PUFA concentrations were measured using nuclear magnetic resonance spectroscopy at age 8 y (n = 557). Dietary patterns were derived using principal component analysis from a validated food frequency questionnaire at age 7 y. Academic performance was assessed using the Wechsler Individual Achievement Test-III at age 9 y (n = 288) and the primary school leaving examination (PSLE) at age 12 y (n = 408). The relationships of LC-PUFAs to academic performance scores were examined using multivariable linear regression models. RESULTS: Percent DHA at age 8 y was associated with higher reading fluency beta [95% confidence interval (CI)] = 3.54 (0.52, 6.56), P = 0.022 and spelling scores [4.49 (0.02, 8.95); P = 0.021] at age 9 y, and lower PSLE scores [beta (95% CI) =-1.43 (-2.68, -0.618); P = 0.025] (indicating better performance) at age 12 y. However, these associations were attenuated after adjusting for an unhealthy dietary pattern. Total n-3 LC-PUFA at age 8 y was associated with higher reading fluency [beta (95% CI) =1.55 (0.03, 3.07); P = 0.046] scores at age 9 y, and lower PSLE scores [beta (95% CI) =-0.83 (-1.42, -0.24); P = 0.006] at age 12 y. The association with PSLE scores remained significant even after adjusting for healthy or unhealthy dietary patterns [beta (95% CI) =-0.68 (-1.29, -0.08); P = 0.028]. CONCLUSIONS: Higher plasma total n-3 LC-PUFA and DHA were prospectively associated with better academic performance in primary school children, but the relationship with DHA was modulated by an unhealthy dietary pattern. The results suggest that beyond DHA, total n-3 LC-PUFA status plays a significant role in the cognitive development of children. CI - Copyright (c) 2026 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Tan, Karen Mei-Ling AU - Tan KM AD - Human Development Division, Institute for Human Development and Potential, Agency for Science, Technology and Research, Singapore; Department of Laboratory Medicine, National University Hospital, Singapore. FAU - Lai, Jun Shi AU - Lai JS AD - Human Development Division, Institute for Human Development and Potential, Agency for Science, Technology and Research, Singapore. FAU - Toh, Jia Ying AU - Toh JY AD - Human Development Division, Institute for Human Development and Potential, Agency for Science, Technology and Research, Singapore. FAU - Ong, Yi Ying AU - Ong YY AD - Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. FAU - Kee, Michelle Zl AU - Kee MZ AD - Human Development Division, Institute for Human Development and Potential, Agency for Science, Technology and Research, Singapore. FAU - Pang, Wei Wei AU - Pang WW AD - Global Centre for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Bia-Echo Asia Centre for Reproductive Longevity & Equality, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore. FAU - Leow, Melvin Khee Shing AU - Leow MKS AD - Human Development Division, Institute for Human Development and Potential, Agency for Science, Technology and Research, Singapore; Department of Endocrinology, Division of Medicine, Tan Tock Seng Hospital, Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore; Nutrition and Digestive Health Division, Singapore Institute for Food and Biotechnology Innovation, Agency for Science, Technology and Research, Singapore. FAU - Yap, Fabian AU - Yap F AD - Department of Pediatric Endocrinology, KK Women's and Children's Hospital, Singapore; SingHealth Duke-NUS Paediatrics Academic Clinical Programme, Duke-National University of Singapore Medical School, Singapore. FAU - Eriksson, Johan Gunnar AU - Eriksson JG AD - Human Development Division, Institute for Human Development and Potential, Agency for Science, Technology and Research, Singapore; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore; Life Cycle Research, Folkhalsan Research Center, Helsinki, Finland; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland. FAU - Cameron-Smith, David AU - Cameron-Smith D AD - Riddet Institute, Massey University, Palmerston North, New Zealand. FAU - Meaney, Michael AU - Meaney M AD - Human Development Division, Institute for Human Development and Potential, Agency for Science, Technology and Research, Singapore; Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada; Sackler Program for Epigenetics & Psychobiology at McGill University, Montreal, QC, Canada. FAU - Law, Evelyn Chung Ning AU - Law ECN AD - Human Development Division, Institute for Human Development and Potential, Agency for Science, Technology and Research, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Paediatrics, Khoo Teck Puat-National University Children's Medical Institute, National University Hospital, Singapore. FAU - Chong, Mary Foong-Fong AU - Chong MF AD - Human Development Division, Institute for Human Development and Potential, Agency for Science, Technology and Research, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, and National University Health System, Singapore. Electronic address: mary_chong@nus.edu.sg. LA - eng PT - Journal Article DEP - 20260204 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 RN - 0 (Fatty Acids, Omega-3) RN - 25167-62-8 (Docosahexaenoic Acids) SB - IM MH - Humans MH - Child MH - Singapore MH - Male MH - Female MH - Prospective Studies MH - *Fatty Acids, Omega-3/blood MH - *Diet, Healthy MH - *Academic Performance MH - Cohort Studies MH - Docosahexaenoic Acids/blood MH - Asian People MH - Cognition MH - Diet OTO - NOTNLM OT - academic achievement OT - childhood OT - cognitive development OT - docosahexaenoic acid OT - omega-3 long chain polyunsaturated fatty acid COIS- Conflict of interest MF-FC reports financial support was provided by National Medical Research Council. All other authors report no conflicts of interest. EDAT- 2026/02/07 00:30 MHDA- 2026/04/04 00:36 CRDT- 2026/02/06 19:16 PHST- 2025/10/22 00:00 [received] PHST- 2026/01/10 00:00 [revised] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/04/04 00:36 [medline] PHST- 2026/02/07 00:30 [pubmed] PHST- 2026/02/06 19:16 [entrez] AID - S0002-9165(26)00042-0 [pii] AID - 10.1016/j.ajcnut.2026.101233 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Apr;123(4):101233. doi: 10.1016/j.ajcnut.2026.101233. Epub 2026 Feb 4. PMID- 41650172 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 2 DP - 2026 TI - Comparison of laboratory-based and non-laboratory-based WHO and GLOBORISK CVD risk scores: A cross-sectional analysis of the APCAPS cohort. PG - e0342471 LID - 10.1371/journal.pone.0342471 [doi] LID - e0342471 AB - BACKGROUND AND AIM: Cardiovascular diseases (CVDs) represent a growing public-health challenge in India, where nearly one in four deaths is CVD-related. Accurate risk stratification underpins targeted prevention, yet laboratory-dependent tools are often impractical in resource-limited settings. The World Health Organization (WHO) and GLOBORISK initiatives both offer non-laboratory-based 10-year CVD risk algorithms alongside their laboratory-based counterparts. We aimed to compare laboratory- and non-laboratory-based WHO and GLOBORISK CVD risk scores, assess their concordance, and examine relationships with sub-clinical atherosclerosis in a rural Indian cohort. MATERIALS AND METHODS: We conducted a cross-sectional analysis of 2,465 adults (1,184 men, 1,281 women) aged 40-74 years from the third wave (2010-12) of the Andhra Pradesh Children and Parents Study (APCAPS). Participants with prior CVD were excluded. Ten-year CVD risk was calculated using sex-specific WHO (South Asia) and India-calibrated GLOBORISK models, both laboratory-based (age, sex, smoking, systolic blood pressure, diabetes, total cholesterol) and non-laboratory-based (age, sex, smoking, systolic blood pressure, BMI) algorithms. Categorical agreement was quantified via percentage agreement and quadratic weighted kappa (kappa); continuous agreement by Bland-Altman analysis. We also evaluated linear associations between each risk score (categorical and continuous) and three sub-clinical atherosclerosis markers: carotid intima-media thickness (CIMT), pulse-wave velocity (PWV), and augmentation index (AIx), through sex-stratified multi-level linear regression with random intercept at the household level, adjusting for multiple testing (p < 0.01). RESULTS: Median WHO-CVD-risk was 6.0% (IQR 4% - 9%) in men and 3.0% (2% - 4%) in women for both lab and non-lab models; median GLOBORISK-CVD-risk was 12.0% (9% - 16%) for lab-model vs. 15.0% (10% - 16%) for non-lab-model in men and 5.0% (3% - 9%) for lab-model vs. 5.0% (3% - 9%) for non-lab-model in women. Categorical agreement was substantial to almost perfect: WHO kappa = 0.82 (overall), GLOBORISK kappa = 0.72. Bland-Altman analyses demonstrated mean differences <1% between lab- and non-lab-based scores, though non-lab models underestimated risk by 4.2% in diabetics and 1.2% in participants with total cholesterol >/=200 mg/dL. Both risk scores showed positive, dose-response relationships with CIMT, PWV, and AIx (p-trend<0.001), with each SD increase in CVD-scores associated with clinically meaningful increases in all three markers of sub-clinical atheroscerosis. CONCLUSION: Non-laboratory-based WHO and GLOBORISK CVD risk scores exhibit high overall agreement with laboratory-based models and correlate strongly with subclinical atherosclerosis in rural India. However, modest underestimation in high-risk subgroups (diabetics, hypercholesterolemia) warrants cautious interpretation. These findings support the feasibility of non-lab risk assessment in resource-constrained settings, while underscoring the need for prospective validation against hard cardiovascular outcomes prior to large-scale implementation. CI - Copyright: (c) 2026 Mahajan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Mahajan, Hemant AU - Mahajan H AUID- ORCID: 0000-0001-7874-9191 AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, India. FAU - Mallinson, Poppy Alice Carson AU - Mallinson PAC AD - London School of Hygiene & Tropical Medicine, London, United Kingdom. FAU - Lieber, Judith AU - Lieber J AD - London School of Hygiene & Tropical Medicine, London, United Kingdom. FAU - Bhogadi, Santhi AU - Bhogadi S AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, India. FAU - Banjara, Santosh Kumar AU - Banjara SK AUID- ORCID: 0000-0002-0893-9552 AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, India. FAU - Shah, Anoop AU - Shah A AD - London School of Hygiene & Tropical Medicine, London, United Kingdom. FAU - Gupta, Vipin AU - Gupta V AD - University of Delhi, Delhi, India. FAU - Walia, Gagandeep Kaur AU - Walia GK AD - Public Health Foundation of India, Delhi, India. FAU - Kulkarni, Bharati AU - Kulkarni B AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, India. FAU - Kinra, Sanjay AU - Kinra S AD - London School of Hygiene & Tropical Medicine, London, United Kingdom. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260206 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Male MH - Cross-Sectional Studies MH - *Cardiovascular Diseases/epidemiology/diagnosis MH - Adult MH - Female MH - Aged MH - Middle Aged MH - World Health Organization MH - India/epidemiology MH - Risk Assessment/methods MH - Risk Factors MH - Cohort Studies MH - Algorithms PMC - PMC12880651 COIS- No authors have competing interests. EDAT- 2026/02/06 18:30 MHDA- 2026/02/06 18:31 PMCR- 2026/02/06 CRDT- 2026/02/06 13:43 PHST- 2025/07/21 00:00 [received] PHST- 2026/01/23 00:00 [accepted] PHST- 2026/02/06 18:31 [medline] PHST- 2026/02/06 18:30 [pubmed] PHST- 2026/02/06 13:43 [entrez] PHST- 2026/02/06 00:00 [pmc-release] AID - PONE-D-25-38253 [pii] AID - 10.1371/journal.pone.0342471 [doi] PST - epublish SO - PLoS One. 2026 Feb 6;21(2):e0342471. doi: 10.1371/journal.pone.0342471. eCollection 2026. PMID- 41648934 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260706 IS - 2047-2986 (Electronic) IS - 2047-2978 (Print) IS - 2047-2978 (Linking) VI - 16 DP - 2026 Feb 6 TI - Associations of sedentary behaviour and physical activity with stress-related sleep disturbance among adolescents in 69 countries: a population-based study. PG - 04049 LID - 10.7189/jogh.16.04049 [doi] LID - 04049 AB - BACKGROUND: Stress-related sleep disturbance have become a serious public health problem among adolescents worldwide. There is a paucity of research employing standardised methodologies to evaluate the association between sedentary behaviour, physical activity, and stress-related sleep disturbance among adolescents. We aimed to examine the association between sedentary behaviour and/or physical activity with stress-related sleep disturbance among adolescents worldwide. METHODS: We used data from the Global School-based Student Health Survey (GSHS) conducted from 2010 to 2019, encompassing 275 483 adolescents aged 12-17 years across 69 countries. Multi-variable logistic regression analysis was performed to assess the independent and joint effect of sedentary behaviour and physical activity on stress-related sleep disturbance. RESULTS: 30.0% of adolescents spend >/=2 hours in sedentary behaviour daily, only 15.4% engage in physical activity for over one hour each day, and 8.3% of adolescents suffer from stress-related sleep disturbances. Compared with those who engaged sedentary behaviour <2 hours/day, 3-4 hours (odds ratio (OR) = 1.168; 95% CI = 1.027-1.329), 5-6 hours (OR = 1.413; 95% CI = 1.169-1.707), and >/=7 hours (OR = 1.792; 1.548-2.076) of daily sedentary behaviour are positively associated with stress-related sleep disturbances among adolescents. Compared with adolescents with low sedentary behaviour and sufficient physical activity, adolescents with low sedentary behaviour and insufficient physical activity (OR = 1.303; 95% CI = 1.052-1.615), high sedentary behaviour and insufficient physical activity (OR = 1.666; 95% CI = 1.350-2.056), and adolescents with high sedentary behaviour and sufficient physical activity (OR = 1.852; 95% CI = 1.432-2.396) are positively associated with stress-related sleep disturbance. CONCLUSIONS: Sedentary behaviour is associated with a higher risk of stress-related sleep disturbances among adolescents. Reducing sedentary behaviour time may serve as a potential intervention strategy for addressing stress-related sleep disturbances, while the potential benefits of increasing physical activity require further research and validation. CI - Copyright (c) 2026 by the Journal of Global Health. All rights reserved. FAU - Li, Jingpeng AU - Li J AD - Department of Epidemiology and Health Statistics, The First Dongguan Affiliated Hospital, School of Public Health, Guangdong Medical University, Dongguan, China. FAU - Zhu, Yongliang AU - Zhu Y AD - Department of Epidemiology and Health Statistics, The First Dongguan Affiliated Hospital, School of Public Health, Guangdong Medical University, Dongguan, China. FAU - Huang, Danyi AU - Huang D AD - Department of Epidemiology and Health Statistics, The First Dongguan Affiliated Hospital, School of Public Health, Guangdong Medical University, Dongguan, China. FAU - Pan, Mengna AU - Pan M AD - Department of Epidemiology and Health Statistics, The First Dongguan Affiliated Hospital, School of Public Health, Guangdong Medical University, Dongguan, China. FAU - Li, Fei AU - Li F AD - Department of children and wellness, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China. FAU - Li, Liuqing AU - Li L AD - Department of Preventive Medicine, The First Dongguan Affiliated Hospital, School of Public Health, Guangdong Medical University, Dongguan, China. FAU - Sun, Jiahong AU - Sun J AD - Department of Preventive Medicine, The First Dongguan Affiliated Hospital, School of Public Health, Guangdong Medical University, Dongguan, China. FAU - Ma, Chuanwei AU - Ma C AD - Department of Epidemiology and Health Statistics, The First Dongguan Affiliated Hospital, School of Public Health, Guangdong Medical University, Dongguan, China. FAU - Zhang, Bingsong AU - Zhang B AD - Department of Epidemiology and Health Statistics, The First Dongguan Affiliated Hospital, School of Public Health, Guangdong Medical University, Dongguan, China. LA - eng PT - Journal Article DEP - 20260206 PL - Scotland TA - J Glob Health JT - Journal of global health JID - 101578780 SB - IM MH - Humans MH - Adolescent MH - *Sedentary Behavior MH - Female MH - Male MH - *Sleep Wake Disorders/epidemiology MH - *Exercise/psychology MH - *Stress, Psychological/epidemiology/complications MH - Child MH - *Global Health/statistics & numerical data MH - Health Surveys PMC - PMC12879260 COIS- Disclosure of interest: The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests. EDAT- 2026/02/06 13:18 MHDA- 2026/02/06 13:19 PMCR- 2026/02/06 CRDT- 2026/02/06 06:32 PHST- 2026/02/06 13:19 [medline] PHST- 2026/02/06 13:18 [pubmed] PHST- 2026/02/06 06:32 [entrez] PHST- 2026/02/06 00:00 [pmc-release] AID - jogh-16-04049 [pii] AID - 10.7189/jogh.16.04049 [doi] PST - epublish SO - J Glob Health. 2026 Feb 6;16:04049. doi: 10.7189/jogh.16.04049. PMID- 41644024 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260929 IS - 1532-8503 (Electronic) IS - 1051-2276 (Linking) VI - 36 IP - 5 DP - 2026 Sep TI - Structured Appetite Assessment in Children With Chronic Kidney Disease. PG - 725-729 LID - S1051-2276(26)00012-9 [pii] LID - 10.1053/j.jrn.2026.01.003 [doi] AB - OBJECTIVES: Appetite disturbances are common in children with chronic kidney disease (CKD). Although appetite assessment is recommended in clinical practice, no validated tools exist for structured evaluation. This study explores appetite in pediatric CKD and validates a simplified, user-friendly assessment tool. METHODS: Following its construction, the ModSNAQ tool was assessed for content validity and employed in an observational cross-sectional study of children with CKD to validate it against dietary intake. The ModSNAQ scores were used to explore relationships of appetite and clinical data, including follow-up outcomes of growth and renal function at 12 months. RESULTS: The tool showed excellent content validity. In the cohort of children with CKD (mean glomerular filtration rate = 52 mL/minute/1.73 m(2)), almost a quarter rated their appetite as poor/very poor. Although not correlating with renal function, ModSNAQ scores predicted meeting energy and protein intake and correlated with height. Change in height and renal function at 12 months did not correspond with ModSNAQ scores, but those with poor appetite had an increase in body mass index. CONCLUSIONS: The ModSNAQ is validated against dietary intake and offers a structured approach to appetite assessment. Using this tool, low appetite is more common than previously reported in CKD and does not correlate with degree of renal impairment. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Harmer, Matthew J AU - Harmer MJ AD - Southampton Children's Hospital, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre-Nutrition, University Hospital Southampton NHS Foundation Trust, Southampton, UK. Electronic address: matthew.harmer@uhs.nhs.uk. FAU - Wootton, Steve AU - Wootton S AD - Faculty of Medicine, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre-Nutrition, University Hospital Southampton NHS Foundation Trust, Southampton, UK. FAU - Gilbert, Rodney D AU - Gilbert RD AD - Southampton Children's Hospital, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine, University of Southampton, Southampton, UK. FAU - Anderson, Caroline AU - Anderson C AD - Southampton Children's Hospital, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre-Nutrition, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Department of Nutrition and Dietetics, University Hospital Southampton NHS Foundation Trust, Southampton, UK. LA - eng PT - Journal Article PT - Observational Study PT - Validation Study DEP - 20260203 PL - United States TA - J Ren Nutr JT - Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation JID - 9112938 SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Male MH - *Appetite/physiology MH - Body Mass Index MH - Cross-Sectional Studies MH - Energy Intake MH - Glomerular Filtration Rate MH - *Nutrition Assessment MH - *Renal Insufficiency, Chronic/physiopathology/complications MH - Reproducibility of Results OTO - NOTNLM OT - CKD OT - appetite OT - assessment tool OT - children EDAT- 2026/02/06 00:30 MHDA- 2026/09/25 23:47 CRDT- 2026/02/05 19:18 PHST- 2024/09/09 00:00 [received] PHST- 2025/11/30 00:00 [revised] PHST- 2026/01/23 00:00 [accepted] PHST- 2026/09/25 23:47 [medline] PHST- 2026/02/06 00:30 [pubmed] PHST- 2026/02/05 19:18 [entrez] AID - S1051-2276(26)00012-9 [pii] AID - 10.1053/j.jrn.2026.01.003 [doi] PST - ppublish SO - J Ren Nutr. 2026 Sep;36(5):725-729. doi: 10.1053/j.jrn.2026.01.003. Epub 2026 Feb 3. PMID- 41642415 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260713 IS - 1862-3514 (Electronic) VI - 21 IP - 1 DP - 2026 Feb 5 TI - Knowledge of osteoporosis prevention among health science students in North Africa: a descriptive correlational cross-sectional study. PG - 32 LID - 10.1007/s11657-026-01662-4 [doi] AB - This study aimed to describe the level of knowledge about osteoporosis prevention among health science students and to identify influencing factors. Results show a low level of knowledge regarding osteoporosis 13.27 +/- 3.67 out of 32. Also influencing factors were such as gender (p = 0.007), age (p = 0.003), living environment (p = 0.009) and educational level (p = 0.017). PURPOSE: The Purpose of this study was to describe the level of knowledge about osteoporosis prevention among health science students and to identify influencing factors. METHODS: A descriptive correlational study was conducted among 524 health science students enrolled at the Higher School of Health Sciences and Techniques of Sousse (HSHSTS) and the Higher Institute of Nursing Sciences of Sousse (HINSS), Tunisia. Data were collected using a validated, self-administered questionnaire based on the revised Osteoporosis Knowledge Test (OKT). The OKT included two subscales assessing knowledge of osteoporosis prevention through physical activity and nutrition. Each correct response was awarded one point, while incorrect or "unknown" answers received zero points. The questionnaire also gathered sociodemographic information, including gender, age, living environment, and educational level. RESULTS: The participants had a mean age of 20.5 +/- 1.4 years. Overall, 71.8% of students demonstrated a low level of knowledge regarding osteoporosis. The mean total knowledge score was 13.27 +/- 3.67 out of 32. Female students scored significantly higher on the overall OKT compared to males (p = 0.007). Physical activity subscale scores were significantly associated with gender (p = 0.005), age (p = 0.003), living environment (p = 0.009), and education level (p = 0.010). Similarly, nutrition-related knowledge showed significant associations with gender (p < 0.001), age (p = 0.001), living environment (p = 0.033), and education level (p = 0.002). CONCLUSION: Key limitations include the cross-sectional design, possible participation bias from differing response rates between institutions, and a markedly imbalanced sex ratio, which may limit generalizability. These findings highlight the need for targeted educational interventions and early integration of osteoporosis content into university curricula to improve knowledge. CI - (c) 2026. The Author(s), under exclusive licence to the International Osteoporosis Foundation and the Bone Health and Osteoporosis Foundation. FAU - Belgacem, Amina AU - Belgacem A AUID- ORCID: 0000-0002-0449-631X AD - University of Sousse, Higher School of Health Sciences and Techniques of Sousse, Street TAJIKISTAN Sahloul II, 4054, Sousse, Tunisia. aminabelgacem04@gmail.com. FAU - Chbili, Chahra AU - Chbili C AD - University of Sousse, Higher School of Health Sciences and Techniques of Sousse, Street TAJIKISTAN Sahloul II, 4054, Sousse, Tunisia. AD - 2Metabolic Biophysics and Applied Pharmacology Laboratory, Faculty of Medicine of Sousse, Sousse University, Sousse, Tunisia. FAU - Maitigue, Mahmoud Ben AU - Maitigue MB AD - Department of Orthopedic. Surgery, University Hospital Sahloul Route Ceinture Cited Sahloul, 4054, Sousse, Tunisia. FAU - Brahem, Hamza AU - Brahem H AD - University of Sousse, Higher School of Health Sciences and Techniques of Sousse, Street TAJIKISTAN Sahloul II, 4054, Sousse, Tunisia. FAU - Brahem, Acil AU - Brahem A AD - University of Sousse, Higher School of Health Sciences and Techniques of Sousse, Street TAJIKISTAN Sahloul II, 4054, Sousse, Tunisia. FAU - Charfeddine, Bassem AU - Charfeddine B AD - University of Sousse, Higher School of Health Sciences and Techniques of Sousse, Street TAJIKISTAN Sahloul II, 4054, Sousse, Tunisia. FAU - Soussi, Sonia AU - Soussi S AUID- ORCID: 0009-0007-4168-4030 AD - University of Tunis El Manar, Higher School of Health Sciences and Techniques of Tunis, La Rabta-Bab Saadoun, B.P. 176-1007, Tunis, Tunisia. LA - eng PT - Journal Article DEP - 20260205 PL - England TA - Arch Osteoporos JT - Archives of osteoporosis JID - 101318988 SB - IM MH - Humans MH - Female MH - Male MH - Cross-Sectional Studies MH - *Osteoporosis/prevention & control MH - *Health Knowledge, Attitudes, Practice MH - Surveys and Questionnaires MH - Young Adult MH - Tunisia MH - Adult MH - *Students MH - Adolescent OTO - NOTNLM OT - Calcium intake OT - Health science students OT - Knowledge OT - Osteoporosis prevention OT - Physical activity COIS- Declarations. Ethics approval: All procedures performed in study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study has been approved by the appropriate institutional and/or national research ethics committee (Ethic Committee of Faculty of Medicine of Sousse). Informed consent: Informed consent was obtained from all individual participants included in the study. Conflicts of interest: None. EDAT- 2026/02/05 19:05 MHDA- 2026/02/05 19:06 CRDT- 2026/02/05 12:05 PHST- 2025/05/20 00:00 [received] PHST- 2026/01/20 00:00 [accepted] PHST- 2026/02/05 19:06 [medline] PHST- 2026/02/05 19:05 [pubmed] PHST- 2026/02/05 12:05 [entrez] AID - 10.1007/s11657-026-01662-4 [pii] AID - 10.1007/s11657-026-01662-4 [doi] PST - epublish SO - Arch Osteoporos. 2026 Feb 5;21(1):32. doi: 10.1007/s11657-026-01662-4. PMID- 41641667 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260927 IS - 2047-6310 (Electronic) IS - 2047-6302 (Print) IS - 2047-6302 (Linking) VI - 21 IP - 2 DP - 2026 Feb TI - Household Food Insecurity Is Associated With Higher Adiposity Over Time Among Adolescents in Louisiana. PG - e70084 LID - 10.1111/ijpo.70084 [doi] LID - e70084 AB - BACKGROUND: Few studies have examined how household food insecurity may impact longitudinal changes in adiposity among adolescents. OBJECTIVE: We investigated the link between household food insecurity and 2-year change in adolescent adiposity, with sex as a potential moderator. METHODS: Analyses included 222 adolescents living in and around Baton Rouge, Louisiana, who participated in the TIGER Kids study (baseline: June 2016-December 2017; follow-up: January 2018-August 2019). Household food security was measured using a validated two-question parent-reported survey. Adiposity outcomes were collected using anthropometry, dual-energy X-ray absorptiometry and abdominal magnetic resonance imaging (MRI). Multivariable multilevel models assessed associations between household food security and changes in adiposity. RESULTS: At baseline, the participants were 12.9 +/- 1.9 years, 50.5% female, 37.4% non-White or Hispanic, 31.5% had obesity, and 11.3% were food insecure. Food-insecure adolescents exhibited significantly greater increases in BMI(p95) (b = 6.0% +/- 2.2%, p = 0.0082), waist circumference (b = 4.1 +/- 1.7 cm, p = 0.0158), total body fat percentage (b = 3.0% +/- 1.3%, p = 0.0194) and visceral adipose tissue mass (b = 0.16 +/- 0.06 kg, p = 0.0163), compared to their food-secure peers. The effect of food insecurity on adiposity did not differ between boys and girls. CONCLUSIONS: This longitudinal study highlights the deleterious influence of food insecurity on adolescent adiposity. Efforts to alleviate food insecurity may play an important role in preventing obesity in adolescents. CI - (c) 2026 The Author(s). Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation. FAU - Fenton, Ashley AU - Fenton A AUID- ORCID: 0009-0002-9519-8613 AD - School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA. FAU - Staiano, Amanda E AU - Staiano AE AD - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA. FAU - Celestin, Michael AU - Celestin M AD - School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA. FAU - Ferguson, Tekeda AU - Ferguson T AD - School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA. FAU - Myers, Candice A AU - Myers CA AD - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA. FAU - Tseng, Tung-Sung AU - Tseng TS AD - School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA. FAU - Broyles, Stephanie T AU - Broyles ST AD - School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA. AD - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA. LA - eng GR - NCT02784509/ClinicalTrials.gov/ GR - U54 GM104940/NH/NIH HHS/United States GR - P30 DK072476/DK/NIDDK NIH HHS/United States GR - 3092-51000-056-04A/United States Department of Agriculture/ GR - U54 GM104940/GM/NIGMS NIH HHS/United States GR - P30DK072476/NH/NIH HHS/United States PT - Journal Article PL - England TA - Pediatr Obes JT - Pediatric obesity JID - 101572033 SB - IM MH - Humans MH - Female MH - Male MH - Louisiana/epidemiology MH - *Adiposity/physiology MH - Adolescent MH - *Food Insecurity MH - Child MH - Longitudinal Studies MH - *Pediatric Obesity/epidemiology PMC - PMC12874501 OTO - NOTNLM OT - adiposity OT - adolescents OT - food insecurity OT - longitudinal study OT - obesity COIS- The authors declare no conflicts of interest. EDAT- 2026/02/05 17:34 MHDA- 2026/02/05 17:35 PMCR- 2026/02/05 CRDT- 2026/02/05 06:33 PHST- 2025/12/05 00:00 [revised] PHST- 2025/04/04 00:00 [received] PHST- 2026/01/08 00:00 [accepted] PHST- 2026/02/05 17:35 [medline] PHST- 2026/02/05 17:34 [pubmed] PHST- 2026/02/05 06:33 [entrez] PHST- 2026/02/05 00:00 [pmc-release] AID - IJPO70084 [pii] AID - 10.1111/ijpo.70084 [doi] PST - ppublish SO - Pediatr Obes. 2026 Feb;21(2):e70084. doi: 10.1111/ijpo.70084. PMID- 41641503 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260921 IS - 1461-7005 (Electronic) IS - 1362-3613 (Print) IS - 1362-3613 (Linking) VI - 30 IP - 3 DP - 2026 Mar TI - Sleep and activity patterns in autism. PG - 767-787 LID - 10.1177/13623613251413538 [doi] AB - Autism is a heritable neurodevelopmental condition marked by impaired social interaction, repetitive behavior, and co-occurring conditions. Sleep disturbances are common in autism. This study uses low-cost wearable devices to compare sleep, physical activity, and circadian behavior in autistic adults and their non-autistic relatives. We recruited 318 autistic individuals and 130 family members, collecting accelerometer data over 3 weeks (8249 days). Using a data-driven approach, we identified actimetry-derived features associated with autism. We examined 308 traits using the elastic net algorithm and linear mixed effects regressions. We identified 52 actimetry measures associated with autism (area under the curve: 0.812; confidence interval: 0.761-0.862), validated in a test set (area under the curve: 0.756; confidence interval: 0.700-0.813). Both mean and day-to-day variability in several measures (e.g., time spent sedentary, total light physical activity) were associated with autism. In autistic individuals, reduced physical activity during wake was more strongly associated with shorter sleep time than in non-autistic relatives (likelihood ratio: 41.6; p = 1.13e-10). Reduced physical activity in autistic individuals was linked to increased social impairment, as measured by the Social Responsiveness Scale. Long inactivity periods and lower physical activity levels were associated with autism, correlating with less sleep and later sleep onset. Interventional studies are needed to explore if improving sleep and physical activity can improve the quality of life for autistic individuals.Lay AbstractAutistic individuals frequently report problems with their sleep, though what aspects of sleep are most affected is not well understood. In this study, we recruited 318 adult autistic participants without intellectual disability and 130 of their non-autistic family members to measure their sleep, physical activity, and daily routines. Study participants wore accelerometer-based wrist-worn devices over 3 consecutive weeks to record their movement and activity. In total, 154 distinct physical activity, sleep, and behavioral traits were identified from the recordings, 52 of which were found to associate with autism. Many of these traits were related to physical activity, where autistic individuals were more likely to be less active for longer periods and have lower overall physical activity levels. Long periods of inactivity also associated with less sleep, with a stronger association in those with autism. For example, for every hour of inactivity, autistic participants had on average ~23 min less of sleep compared to ~17 min in their family members. Autistic individuals with lower levels of physical activity showed higher social impairment as measured by the Social Responsiveness Scale. Overall, lower physical activity may impair sleep and worsen the core features of autism. Interventional studies aimed to increase physical activity may improve the quality of life of autistic individuals. FAU - Weissenkampen, J Dylan AU - Weissenkampen JD AUID- ORCID: 0000-0003-1928-5184 AD - University of Pennsylvania, USA. FAU - Ghorai, Arpita AU - Ghorai A AD - University of Pennsylvania, USA. FAU - Carneiro, Thaise Nr AU - Carneiro TN AD - University of Pennsylvania, USA. FAU - Fasolino, Maria AU - Fasolino M AD - University of Pennsylvania, USA. FAU - Gehringer, Brielle N AU - Gehringer BN AUID- ORCID: 0000-0002-5737-6610 AD - University of Pennsylvania, USA. FAU - Rajan, Maya AU - Rajan M AD - University of Pennsylvania, USA. FAU - Dow, Holly C AU - Dow HC AUID- ORCID: 0000-0002-7718-4261 AD - University of Pennsylvania, USA. FAU - Kunatharaju, Shriya AU - Kunatharaju S AD - University of Pennsylvania, USA. FAU - Roenneberg, Till AU - Roenneberg T AD - Ludwig-Maximilians-University Munich, Germany. FAU - Sebro, Ronnie AU - Sebro R AD - Mayo Clinic, USA. FAU - Rader, Daniel J AU - Rader DJ AD - University of Pennsylvania, USA. FAU - Keenan, Brendan T AU - Keenan BT AD - University of Pennsylvania, USA. FAU - Almasy, Laura AU - Almasy L AD - University of Pennsylvania, USA. AD - Children's Hospital of Philadelphia, USA. FAU - Brodkin, Edward S AU - Brodkin ES AUID- ORCID: 0000-0003-1417-7838 AD - University of Pennsylvania, USA. FAU - Bucan, Maja AU - Bucan M AUID- ORCID: 0000-0002-5684-1736 AD - University of Pennsylvania, USA. LA - eng GR - P30 ES013508/ES/NIEHS NIH HHS/United States GR - R01 MH093415/MH/NIMH NIH HHS/United States GR - T32 ES019851/ES/NIEHS NIH HHS/United States PT - Journal Article DEP - 20260205 PL - England TA - Autism JT - Autism : the international journal of research and practice JID - 9713494 SB - IM UOF - bioRxiv. 2024 May 07:2024.05.02.592263. doi: 10.1101/2024.05.02.592263. PMID: 38766266 MH - Humans MH - Male MH - Female MH - Adult MH - *Autistic Disorder/physiopathology/complications MH - *Exercise/physiology MH - Sleep Duration MH - *Sleep/physiology MH - Young Adult MH - Middle Aged MH - Circadian Rhythm MH - Accelerometry MH - *Sleep Wake Disorders/physiopathology MH - Actigraphy MH - Adolescent PMC - PMC12923632 OTO - NOTNLM OT - actimetry OT - autism OT - circadian behavior OT - physical activity OT - sleep COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/02/05 06:31 MHDA- 2026/02/25 10:21 PMCR- 2026/02/21 CRDT- 2026/02/05 04:47 PHST- 2026/02/25 10:21 [medline] PHST- 2026/02/05 06:31 [pubmed] PHST- 2026/02/05 04:47 [entrez] PHST- 2026/02/21 00:00 [pmc-release] AID - 10.1177_13623613251413538 [pii] AID - 10.1177/13623613251413538 [doi] PST - ppublish SO - Autism. 2026 Mar;30(3):767-787. doi: 10.1177/13623613251413538. Epub 2026 Feb 5. PMID- 41640849 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260706 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Plant-based protein consumption patterns among Saudi Generation Z: a cross-sectional study of dietary frequencies, health outcomes, and sustainable eating behaviors. PG - 1739641 LID - 10.3389/fpubh.2026.1739641 [doi] LID - 1739641 AB - BACKGROUND: The global shift toward sustainable food systems has highlighted plant-based proteins as essential for environmental and health benefits. However, research on plant-based protein consumption among young adults in the Gulf region, particularly in Saudi Arabia, remains limited despite the country's youthful demographic profile and increasing environmental awareness. OBJECTIVE: This cross-sectional study explored plant-based protein consumption patterns frequencies among Saudi Generation Z (Gen Z) aged 18-25, examining associations with health outcomes, sustainable healthy eating behaviors (SHEBs), and readiness to adopt sustainable healthy diets. METHODS: A non-representative convenience sample of 398 Saudi adults was recruited through snowball sampling. Data was collected via an online survey incorporating validated instruments for dietary consumption frequency, SHEB assessment, and stages-of-change measurement. Participants were categorized into three groups based on weekly consumption frequency of plant-based protein sources: low frequency (0-7 portions/week), moderate frequency (8-21 portions/week), and high frequency (>/=22 portions/week). Statistical analyses included analysis of variance, chi-square tests, and binary logistic regression. RESULTS: The median weekly consumption frequency of plant-based protein sources was 14 portions/week (IQR: 7-24), compared to 28 portions/week (IQR: 21-35) for animal-based protein sources. Only 21.4% of participants achieved high consumption frequency (>/=22 portions/week). Higher plant-based protein consumption frequency was associated with lower mean body mass index (BMI) (23.19 +/- 6.58 vs. 24.57 +/- 7.02 kg/m(2) among low-frequency consumers, p = 0.031), greater engagement in SHEBs (mean score: 2.17 +/- 0.43 vs. 1.91 +/- 0.38, p < 0.001), and more advanced stages of change toward adopting plant-based diets (p < 0.001). Health motivations predominated across all groups (>35%), while environmental concerns remained minimal (4.9-7.1%). The majority of participants (83.2%) were in the precontemplation or contemplation stages regarding plant-based diet adoption. CONCLUSION: Plant-based protein consumption among this Saudi Gen Z convenience sample remains markedly lower than animal-based protein intake, indicating limited integration of legumes, nuts, and plant-based alternatives into routine diets. Higher consumption frequency was observed alongside lower BMI and greater engagement in sustainable eating behaviors, suggesting associations that warrant further study. However, the cross-sectional design limits causal interpretation, and consumption frequency reflects behavioral patterns rather than validated nutritional intake or adequacy. Promoting health benefits while respecting traditional food practices may support healthier dietary shifts among young Arabs. CI - Copyright (c) 2026 Al-Otaibi and Al-Hashim. FAU - Al-Otaibi, Hala Hazam AU - Al-Otaibi HH AD - Department of Food and Nutrition Science, College of Agricultural and Food Science, King Faisal University, Al-Ahsa, Saudi Arabia. FAU - Al-Hashim, Sawsan AU - Al-Hashim S AD - Department of Clinical Nutrition, College of Applied Medical Sciences, King Faisal University, Al-Ahsa, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260120 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - 0 (Plant Proteins) SB - IM MH - Humans MH - Saudi Arabia MH - Cross-Sectional Studies MH - Male MH - Female MH - Young Adult MH - Adult MH - *Feeding Behavior MH - Adolescent MH - *Diet, Healthy/statistics & numerical data MH - Diet, Plant-Based MH - *Plant Proteins PMC - PMC12864068 OTO - NOTNLM OT - Arab region OT - Generation Z OT - Saudi Arabia OT - dietary transition OT - environmental awareness OT - gulf countries OT - plant-based protein OT - sustainable healthy diets COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/05 06:32 MHDA- 2026/02/05 06:33 PMCR- 2026/01/20 CRDT- 2026/02/05 04:37 PHST- 2025/11/04 00:00 [received] PHST- 2025/12/24 00:00 [revised] PHST- 2026/01/09 00:00 [accepted] PHST- 2026/02/05 06:33 [medline] PHST- 2026/02/05 06:32 [pubmed] PHST- 2026/02/05 04:37 [entrez] PHST- 2026/01/20 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1739641 [doi] PST - epublish SO - Front Public Health. 2026 Jan 20;14:1739641. doi: 10.3389/fpubh.2026.1739641. eCollection 2026. PMID- 41640515 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260205 LR - 20260207 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 13 DP - 2026 TI - Factors influencing delayed lactogenesis II among advanced-age women following cesarean section: a retrospective analysis and predictive model development. PG - 1733012 LID - 10.3389/fmed.2026.1733012 [doi] LID - 1733012 AB - BACKGROUND: Delayed lactogenesis II (DLII), defined as the onset of copious milk secretion after 72 h postpartum, is a common complication that may impair early breastfeeding success. Advanced maternal age and cesarean delivery are both known risk factors, yet few studies have developed predictive models to identify high-risk women. This study aimed to construct and internally validate a clinical prediction model for DLII among advanced-age women undergoing cesarean section. METHODS: This retrospective observational study analyzed the medical records of 325 women aged >/=35 years who underwent cesarean delivery at a tertiary maternal and child health hospital in Southwest China between January 2021 and January 2025. Maternal, obstetric, surgical, and neonatal variables were extracted from electronic medical records. Univariate and multivariate logistic regression analyses were performed to identify independent predictors of DLII, and a nomogram was subsequently developed. Model discrimination and calibration were assessed using the area under the receiver operating characteristic (ROC) curve (AUC), Hosmer-Lemeshow goodness-of-fit test, and calibration plots with 1,000 bootstrap resamples. RESULTS: Of the 325 women included, 117 (36.0%) experienced DLII. Multivariate analysis identified maternal age (aOR = 1.15, 95% CI 1.01-1.32), pre-pregnancy body mass index (BMI; aOR = 1.10, 95% CI 1.00-1.22), primiparity (aOR = 1.74, 95% CI 1.02-2.96), and shorter gestational age (aOR = 0.71, 95% CI 0.55-0.91) as independent risk factors for DLII. In contrast, elective cesarean section and early postpartum practices (rooming-in within 24 h, breastfeeding initiation within 24 h, and early skin-to-skin contact) were associated with lower odds of delayed lactogenesis II after multivariable adjustment (all p < 0.05). The final model demonstrated excellent discrimination (AUC = 0.870, 95% CI 0.830-0.910) and good calibration (Hosmer-Lemeshow chi (2) = 5.60, p = 0.692). CONCLUSION: This study established a reliable and clinically interpretable model for predicting delayed lactogenesis II among advanced-age women undergoing cesarean section. The model showed high accuracy and good internal validity, highlighting the relevance of maternal characteristics and early postpartum behaviors to lactation outcomes. The proposed nomogram may serve as a practical tool for early risk identification and targeted breastfeeding support in clinical settings. CI - Copyright (c) 2026 Chen, Yu, Wang, Hu and Zhang. FAU - Chen, Lei AU - Chen L AD - Department of Obstetrics, Luzhou Maternal and Child Health Hospital, Luzhou, Sichuan, China. FAU - Yu, Xia AU - Yu X AD - Department of Obstetrics, Luzhou Maternal and Child Health Hospital, Luzhou, Sichuan, China. FAU - Wang, Xiangding AU - Wang X AD - Department of Obstetrics, Luzhou Maternal and Child Health Hospital, Luzhou, Sichuan, China. FAU - Hu, Hong AU - Hu H AD - Department of Obstetrics, Luzhou Maternal and Child Health Hospital, Luzhou, Sichuan, China. FAU - Zhang, Lu AU - Zhang L AD - Department of Child Health Care, Luzhou Maternal and Child Health Hospital, Luzhou, Sichuan, China. LA - eng PT - Journal Article DEP - 20260120 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC12864442 OTO - NOTNLM OT - advanced maternal age OT - breastfeeding OT - cesarean section OT - delayed lactogenesis II OT - lactation OT - predictive model COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/05 06:31 MHDA- 2026/02/05 06:32 PMCR- 2026/01/20 CRDT- 2026/02/05 04:28 PHST- 2025/10/27 00:00 [received] PHST- 2026/01/02 00:00 [revised] PHST- 2026/01/05 00:00 [accepted] PHST- 2026/02/05 06:32 [medline] PHST- 2026/02/05 06:31 [pubmed] PHST- 2026/02/05 04:28 [entrez] PHST- 2026/01/20 00:00 [pmc-release] AID - 10.3389/fmed.2026.1733012 [doi] PST - epublish SO - Front Med (Lausanne). 2026 Jan 20;13:1733012. doi: 10.3389/fmed.2026.1733012. eCollection 2026. PMID- 41639908 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 1479-5868 (Electronic) IS - 1479-5868 (Linking) VI - 23 IP - 1 DP - 2026 Feb 4 TI - Bidirectional associations between smart device use and body mass index among children aged 3 to 5 years: a longitudinal study. LID - 10.1186/s12966-026-01883-3 [doi] LID - 18 AB - BACKGROUND: The increase in smart device use, including smartphones and tablets, among young children has raised concerns about its impact on health, particularly on body mass index (BMI). However, the bidirectional associations between smart device use and BMI in preschoolers remain unclear. This study examined the longitudinal associations, considering the moderating effects of mother-child interactions and child sex. METHODS: Data were obtained from the Longitudinal Examination Across Prenatal and Postpartum Health in Taiwan, a cohort study conducted in Taipei, Taiwan. In total, 590 preschoolers were assessed at ages 3, 4, and 5 years. Smart device use, BMI z-scores, and mother-child interaction quality were evaluated using validated parent-reported questionnaires. The random-intercept cross-lagged panel model was used to investigate bidirectional associations, adjusting for stable confounders. Multiple-group models examined the moderating effects of mother-child interactions and child sex. Model estimates were reported as standardized coefficients. RESULTS: Higher BMI z-scores at age 4 years were linked to increased device use at age 5 years (beta = 0.36; 95% CI, 0.05-0.67). Multiple-group models revealed that among dyads with lower mother-child interactions, higher device use at age 3 years was associated with higher BMI at age 4 years (beta = 0.40; 95% CI, 0.07 to 0.72), which was subsequently linked to greater device use at age 5 years (beta = 0.50; 95% CI, 0.10 to 0.90). Additionally, higher device use at age 4 years was associated with higher BMI at age 5 years (beta = 0.65; 95% CI, 0.31 to 1.00). A similar bidirectional pattern was observed among boys, while no significant cross-lagged associations were found among girls. In contrast, high-quality mother-child interactions revealed higher device use at age 4 years was associated with lower BMI at age 5 years, suggesting a protective role against prolonged device use and subsequent BMI increases. CONCLUSIONS: Our study indicates bidirectional associations between smart device use and BMI among preschoolers, emphasizing the protective role of high-quality mother-child interactions. Interventions should focus on enhancing parent-child relationships, limiting device use, and promoting active engagement. Future studies should investigate the effect of media content and children's self-regulation on these associations. CI - (c) 2026. The Author(s). FAU - Chakranon, Pairote AU - Chakranon P AD - School of Public Health, College of Public Health, Taipei Medical University, New Taipei, Taiwan. FAU - Huang, Jian-Pei AU - Huang JP AD - Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan. FAU - Au, Heng-Kien AU - Au HK AD - Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, Taiwan. AD - Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. FAU - Chiou, Hawjeng AU - Chiou H AD - Department of Business Administration, College of Management, National Taiwan Normal University, Taipei, Taiwan. FAU - Lin, Chen-Li AU - Lin CL AD - Department of Obstetrics & Gynecology, Taipei City Hospital, Heping Fuyou Branch, Taipei, Taiwan. FAU - Chen, Yi-Yung AU - Chen YY AD - Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan. FAU - Mao, Shih-Peng AU - Mao SP AD - Department of Obstetrics and Gynecology, Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare, New Taipei, Taiwan. FAU - Kim, Pilyoung AU - Kim P AD - Department of Psychology, College of Arts, Humanities and Social Sciences, University of Denver, Denver, CO, USA. AD - Department of Psychology, Ewha Womans University, Seoul, South Korea. FAU - Hsu, Hsueh-Wen AU - Hsu HW AD - Master Program in Applied Epidemiology, College of Public Health, Taipei Medical University, Taipei, Taiwan. FAU - Chen, Yi-Hua AU - Chen YH AD - School of Public Health, College of Public Health, Taipei Medical University, New Taipei, Taiwan. yichen.tmu@gmail.com. AD - Neuroscience Research Center, Taipei Medical University, Taipei, Taiwan. yichen.tmu@gmail.com. AD - Research Center of Health Equity, College of Public Health, Taipei Medical University, New Taipei, Taiwan. yichen.tmu@gmail.com. LA - eng GR - NSTC 114-2314-B-038 -039 -MY3, NSTC 114-2621-M-038-001, NSTC 113-2621-M-038-003, NSTC 112-2621-M-038-003, MOST 111-2314-B-038-043-MY3, MOST 108-2314-B-038-083-MY3, MOST 105-2314-B-038-031-MY3, NSC 102-2314-B-038-038-MY3, and NSC 99-2628-B-038-015-MY3/National Science and Technology Council/ GR - the Higher Education Sprout Project; DP2-TMU-112-O-10, DP2-TMU-113-O-04, DP2-TMU-114-O-03/Ministry of Education/ PT - Journal Article DEP - 20260204 PL - England TA - Int J Behav Nutr Phys Act JT - The international journal of behavioral nutrition and physical activity JID - 101217089 SB - IM MH - Humans MH - *Body Mass Index MH - Child, Preschool MH - Female MH - Longitudinal Studies MH - Male MH - Taiwan MH - *Mother-Child Relations MH - *Smartphone/statistics & numerical data MH - Surveys and Questionnaires MH - *Computers, Handheld/statistics & numerical data PMC - PMC12958733 OTO - NOTNLM OT - Body mass index OT - Mother-child interactions OT - Preschooler OT - Smart device use COIS- Declarations. Ethical approval and consent to participate: This study was approved by the Institutional Review Board of MacKay Memorial Hospital (16MMHIS130). Written informed consent was obtained from each participant in this study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/05 06:32 MHDA- 2026/03/07 01:38 PMCR- 2026/02/04 CRDT- 2026/02/05 00:02 PHST- 2025/05/07 00:00 [received] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/03/07 01:38 [medline] PHST- 2026/02/05 06:32 [pubmed] PHST- 2026/02/05 00:02 [entrez] PHST- 2026/02/04 00:00 [pmc-release] AID - 10.1186/s12966-026-01883-3 [pii] AID - 1883 [pii] AID - 10.1186/s12966-026-01883-3 [doi] PST - epublish SO - Int J Behav Nutr Phys Act. 2026 Feb 4;23(1):18. doi: 10.1186/s12966-026-01883-3. PMID- 41639635 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Feb 4 TI - Support and concerns: Dutch health care professionals' views on the use of a childhood obesity prediction toolbox. LID - 10.1186/s12887-026-06572-5 [doi] LID - 184 AB - BACKGROUND: Childhood obesity is a major and increasing public health concern. Early prediction of the risk of childhood obesity may lead to targeted preventative interventions. To develop a prediction-toolbox that is suitable for clinical implementation, it is imperative to align it with the perceptions of health care professionals (HCPs), but this aspect remains relatively underexplored. This study aimed to explore the perceptions of Dutch HCPs regarding the concept of a childhood obesity prediction toolbox. METHODS: A qualitative study design comprising semi-structured interviews (n=15) with Dutch HCPs was used. HCPs included youth health care practitioners, youth health care nurses and policy advisors employed at the municipal health service of Amsterdam. Perceptions were explored regarding the concept of a three-element childhood obesity prediction toolbox of the EndObesity project, which consists of a prediction tool, prevention strategies to support families of high-risk infants, and communication tips for HCPs. The data were analysed through reflexive thematic analysis. RESULTS: HCPs were positive about early identification of the risk of future childhood obesity and the support of high-risk infants. They acknowledged the potential benefits of personalized care facilitated by such risk prediction, but concerns were raised regarding its validity and its added value compared with the clinical judgement of HCPs. HCPs also expressed some negative connotations regarding risk communication e.g. making parents feel insecure or judged, especially in vulnerable situations. Finally, HCPs acknowledged the complexity of childhood obesity prevention and emphasized the need for a complementary broader approach at both the municipal and national policy levels. CONCLUSIONS: Dutch HCPs generally supported the potential use of a childhood obesity prediction toolbox, but they also expressed concerns regarding the validity, the added value of the toolbox and about risk communication. These concerns must be addressed in further development of the toolbox. CI - (c) 2026. The Author(s). FAU - Manshanden, Anna AU - Manshanden A AD - Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. a.manshanden@vu.nl. AD - Amsterdam Public Health, Amsterdam, The Netherlands. a.manshanden@vu.nl. FAU - Groot-Sluijsmans, Barbara AU - Groot-Sluijsmans B AD - Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. AD - Amsterdam Public Health, Amsterdam, The Netherlands. FAU - M'Rani Alaoui, Nohaila AU - M'Rani Alaoui N AD - Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. FAU - Seidell, Jacob C AU - Seidell JC AD - Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. AD - Amsterdam Public Health, Amsterdam, The Netherlands. FAU - Dijkstra, S Coosje AU - Dijkstra SC AD - Amsterdam Public Health, Amsterdam, The Netherlands. AD - Amsterdam UMC, Location Vrije Universiteit Amsterdam, Public and Occupational Health, De Boelelaan 1117, Amsterdam, Netherlands. LA - eng GR - 727565/Horizon 2020 research and innovation program, European Union/ GR - 529051026/ZONMW_/ZonMw/Netherlands PT - Journal Article DEP - 20260204 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Netherlands MH - *Pediatric Obesity/diagnosis/prevention & control MH - *Attitude of Health Personnel MH - Risk Assessment/methods MH - Child MH - Female MH - Male MH - Qualitative Research MH - Interviews as Topic PMC - PMC12958768 OTO - NOTNLM OT - Child OT - Communication OT - Infant OT - Obesity OT - Parents OT - Prevention OT - Qualitative OT - Risk COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki and was approved by the Research Ethics Review Committee of the Faculty of Science of the Vrije Universiteit Amsterdam (BETHCIE). Review number of approval letter: 22-49. Informed consent was obtained from all participants, who were all over 18 years of age. Clinical trial number: not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/05 00:31 MHDA- 2026/03/06 19:44 PMCR- 2026/02/04 CRDT- 2026/02/04 23:44 PHST- 2024/11/18 00:00 [received] PHST- 2026/01/22 00:00 [accepted] PHST- 2026/03/06 19:44 [medline] PHST- 2026/02/05 00:31 [pubmed] PHST- 2026/02/04 23:44 [entrez] PHST- 2026/02/04 00:00 [pmc-release] AID - 10.1186/s12887-026-06572-5 [pii] AID - 6572 [pii] AID - 10.1186/s12887-026-06572-5 [doi] PST - epublish SO - BMC Pediatr. 2026 Feb 4;26(1):184. doi: 10.1186/s12887-026-06572-5. PMID- 41638532 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2212-2672 (Print) IS - 2212-2672 (Linking) VI - 126 IP - 6 DP - 2026 Jun TI - Household Water Insecurity Is Associated With Greater Likelihood of Early Exclusive Breastfeeding Cessation and Diarrhea Among Children Aged 6 to 59 Months in Ethiopia: Data From Haramaya University Health and Demographic Surveillance System. PG - 156303 LID - S2212-2672(26)00018-3 [pii] LID - 10.1016/j.jand.2026.156303 [doi] AB - INTRODUCTION: In low-resource settings, exclusive breastfeeding (EBF) and household water security are recognized contributors to child health. Yet few studies have examined how they are related. OBJECTIVES: This study aims to (1) test the relationship between domains of household water insecurity and EBF cessation before 6 months, and (2) examine the association between water insecurity and recent child diarrheal disease and stunting. DESIGN: The Haramaya University Health and Demographic Surveillance System is a cross-sectional survey. PARTICIPANTS/SETTING: Mother-child (aged 6-59 months) dyads (n = 1019) were recruited from smallholder agricultural households in rural Eastern Ethiopia in 2019. MAIN OUTCOME MEASURES: The primary outcome was EBF cessation before 6 months. Secondary outcomes were children's diarrhea (last 2 weeks) and stunting. Exposure variables assessing water insecurity included time spent fetching water, objective water quality (Escherichia coli presence), water source reliability, and overall household water insecurity status (classified using the Household Water InSecurity Experiences Scale). STATISTICAL ANALYSES: Survey logistic regression models were used to assess associations of water insecurity domains with early EBF cessation, diarrhea, and stunting. RESULTS: Poor water quality (adjusted odds ratio [AOR], 1.42; 95% confidence interval [CI], 1.06-1.98), unreliable water (AOR, 1.44; 95% CI, 1.04-1.98), and water fetching time >30 minutes (AOR, 1.54; 95% CI, 1.15-2.05) were associated with early EBF cessation risk. Children in households classified as moderate (AOR, 1.54; 95% CI, 1.03-2.30) or high water insecurity (AOR, 2.07; 95% CI, 1.33-3.24) had a greater risk of diarrhea. No association was observed between domains of water insecurity and stunting. CONCLUSION: Multiple domains of water insecurity were associated with early EBF cessation, and overall water insecurity was associated with children's diarrheal risk. Water insecurity has been identified as a key programmatic and policy consideration for early childhood nutrition. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Roba, Kedir Teji AU - Roba KT AD - Department of Biobehavioral Health, Pennsylvania State University, University Park, PA, United States; College of Health and Medical Sciences, Haramaya University, Ethiopia. Electronic address: kedir.t.roba@gmail.com. FAU - Roba, Akililu Abrham AU - Roba AA AD - College of Health and Medical Sciences, Haramaya University, Ethiopia. FAU - Hassen, Jemal Yousuf AU - Hassen JY AD - Department of Rural Development and Agricultural Innovation, Haramaya University, Haramaya, Diredawa, Ethiopia. FAU - Thompson, Gretchen AU - Thompson G AD - Department of Behavioral, Epidemiological and Clinical Sciences, FHI 360, Durham, NC 27701, USA. FAU - Brewis, Alexandra AU - Brewis A AD - School of Human Evolution and Social Change, Arizona State University, Tempe, AZ 85284, USA. FAU - Rosinger, Asher Y AU - Rosinger AY AD - Department of Biobehavioral Health, Pennsylvania State University, University Park, PA, United States; Department of Anthropology, Pennsylvania State University, University Park, PA, United States. LA - eng PT - Journal Article DEP - 20260203 PL - United States TA - J Acad Nutr Diet JT - Journal of the Academy of Nutrition and Dietetics JID - 101573920 SB - IM MH - Humans MH - Ethiopia/epidemiology MH - *Breast Feeding/statistics & numerical data MH - Female MH - Cross-Sectional Studies MH - Infant MH - Child, Preschool MH - *Diarrhea/epidemiology/etiology MH - Male MH - Growth Disorders/epidemiology/etiology MH - Family Characteristics MH - *Water Insecurity MH - Rural Population/statistics & numerical data MH - *Water Supply/statistics & numerical data MH - Water Quality OTO - NOTNLM OT - Breastfeeding OT - Ethiopia OT - Stunting OT - Water insecurity OT - Water quality EDAT- 2026/02/05 00:30 MHDA- 2026/05/22 00:33 CRDT- 2026/02/04 19:14 PHST- 2024/07/16 00:00 [received] PHST- 2025/12/22 00:00 [revised] PHST- 2026/01/26 00:00 [accepted] PHST- 2026/05/22 00:33 [medline] PHST- 2026/02/05 00:30 [pubmed] PHST- 2026/02/04 19:14 [entrez] AID - S2212-2672(26)00018-3 [pii] AID - 10.1016/j.jand.2026.156303 [doi] PST - ppublish SO - J Acad Nutr Diet. 2026 Jun;126(6):156303. doi: 10.1016/j.jand.2026.156303. Epub 2026 Feb 3. PMID- 41637624 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260706 IS - 1438-8871 (Electronic) IS - 1439-4456 (Print) IS - 1438-8871 (Linking) VI - 28 DP - 2026 Feb 4 TI - Digital Phenotyping for Adolescent Mental Health: Feasibility Study Using Machine Learning to Predict Mental Health Risk From Active and Passive Smartphone Data. PG - e72501 LID - 10.2196/72501 [doi] LID - e72501 AB - BACKGROUND: Adolescents are particularly vulnerable to mental disorders, with over 75% of lifetime cases emerging before the age of 25 years. Yet most young people with significant symptoms do not seek support. Digital phenotyping, leveraging active (self-reported) and passive (sensor-based) data from smartphones, offers a scalable, low-burden approach for early risk detection. Despite this potential, its application in school-going adolescents from general (nonclinical) populations remains limited, leaving a critical gap in community-based prevention efforts. OBJECTIVE: This study evaluated the feasibility of using a smartphone app to predict mental health risks in nonclinical adolescents by integrating active and passive data streams within a machine learning (ML) framework. We examined the utility of this approach for identifying risks related to internalizing and externalizing difficulties, eating disorders, insomnia, and suicidal ideation. METHODS: Participants (n=103; mean age 16.1 years, SD 1.0) from 3 UK secondary schools used the Mindcraft app (Brain and Behaviour Lab) for 14 days, providing daily self-reports (eg, mood, sleep, and loneliness) and continuous passive sensor data (eg, location, step count, and app usage). We developed a deep learning model incorporating contrastive pretraining with triplet margin loss to stabilize user-specific behavioral patterns, followed by supervised fine-tuning for binary classification of 4 mental health outcomes, namely, the Strengths and Difficulties Questionnaire (SDQ)-high risk, insomnia, suicidal ideation, and eating disorder. Performance was assessed using leave-one-subject-out cross-validation (LOSO-CV), with balanced accuracy as the primary metric. Comparative analyses were conducted using CatBoost (Yandex) and multilayer perceptron (MLP) models without pretraining. Feature importance was assessed using Shapley Additive Explanations (SHAP) values, and associations between key digital features and clinical scales were analyzed. RESULTS: Integration of active and passive data outperformed single-modality models, achieving mean balanced accuracies of 0.71 (0.03) for SDQ-high risk, 0.67 (0.04) for insomnia, 0.77 (0.03) for suicidal ideation, and 0.70 (0.03) for eating disorder. The contrastive learning approach improved representation stability and predictive robustness. SHAP analysis highlighted clinically relevant features, such as negative thinking and location entropy, underscoring the complementary value of combining subjective and objective data. Correlation analyses confirmed meaningful associations between key digital features and mental health outcomes. Performance in an independent external validation cohort (n=45) achieved balanced accuracies of 0.63-0.72 across outcomes, suggesting generalizability to new settings. CONCLUSIONS: This study demonstrates the feasibility and utility of smartphone-based digital phenotyping for predicting mental health risks in nonclinical, school-going adolescents. By integrating active and passive data with advanced machine modeling techniques, this approach shows promise for early detection and scalable intervention strategies in community settings. CI - (c) Balasundaram Kadirvelu, Teresa Bellido Bel, Aglaia Freccero, Martina Di Simplico, Dasha Nicholls, A Aldo Faisal. Originally published in the Journal of Medical Internet Research (https://www.jmir.org). FAU - Kadirvelu, Balasundaram AU - Kadirvelu B AUID- ORCID: 0000-0001-9791-3006 AD - Brain & Behaviour Lab, Department of Computing and Department of Bioengineering, Imperial College London, Royal School of Mines, London, SW72AZ, United Kingdom, 44 20 7594 6373. FAU - Bellido Bel, Teresa AU - Bellido Bel T AUID- ORCID: 0000-0003-3590-6390 AD - Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, England, United Kingdom. FAU - Freccero, Aglaia AU - Freccero A AUID- ORCID: 0009-0002-2072-9838 AD - Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, England, United Kingdom. FAU - Di Simplico, Martina AU - Di Simplico M AUID- ORCID: 0000-0001-5701-9659 AD - Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, England, United Kingdom. FAU - Nicholls, Dasha AU - Nicholls D AUID- ORCID: 0000-0001-7257-6605 AD - Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, England, United Kingdom. FAU - Faisal, A Aldo AU - Faisal AA AUID- ORCID: 0000-0003-0813-7207 AD - Brain & Behaviour Lab, Department of Computing and Department of Bioengineering, Imperial College London, Royal School of Mines, London, SW72AZ, United Kingdom, 44 20 7594 6373. AD - Chair in Digital Health & Data Science, Faculty of Life Sciences, University of Bayreuth, Bayreuth, Bavaria, Germany. LA - eng PT - Journal Article DEP - 20260204 PL - Canada TA - J Med Internet Res JT - Journal of medical Internet research JID - 100959882 SB - IM MH - Humans MH - Adolescent MH - Feasibility Studies MH - *Smartphone MH - Female MH - *Machine Learning MH - Male MH - *Mental Health MH - *Mental Disorders/diagnosis MH - Digital Health MH - *Phenotype MH - Predictive Learning Models MH - *Mobile Applications PMC - PMC12871944 OTO - NOTNLM OT - EMA OT - artificial intelligence OT - digital health OT - early intervention OT - ecological momentary assessment OT - mHealth OT - mobile applications OT - mobile health OT - smartphone sensing OT - youth mental health COIS- Conflicts of Interest: None declared. EDAT- 2026/02/04 19:37 MHDA- 2026/02/04 19:38 PMCR- 2026/02/04 CRDT- 2026/02/04 15:13 PHST- 2025/02/11 00:00 [received] PHST- 2025/12/04 00:00 [revised] PHST- 2025/12/05 00:00 [accepted] PHST- 2026/02/04 19:38 [medline] PHST- 2026/02/04 19:37 [pubmed] PHST- 2026/02/04 15:13 [entrez] PHST- 2026/02/04 00:00 [pmc-release] AID - v28i1e72501 [pii] AID - 72501 [pii] AID - 10.2196/72501 [doi] PST - epublish SO - J Med Internet Res. 2026 Feb 4;28:e72501. doi: 10.2196/72501. PMID- 41635887 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260204 LR - 20260920 IS - 2516-5410 (Electronic) IS - 2096-6938 (Print) IS - 2516-5410 (Linking) VI - 9 IP - 1 DP - 2026 TI - Remote detection of the critical view of safety in pediatric laparoscopic cholecystectomy using artifitial intelligence. PG - e001125 LID - 10.1136/wjps-2025-001125 [doi] LID - e001125 AB - BACKGROUND: Laparoscopic cholecystectomy (LC) is increasingly performed in pediatric patients. Bile duct injury remains one of its most serious complications. The critical view of safety (CVS) aims to reduce this risk, but its identification is subjective. Artificial intelligence (AI) has shown promise in adult surgery for CVS detection but it has not been applied in pediatrics. Remote implementation of AI could reduce subjectivity and improve access to advanced tools. METHODS: A prospective, observational, cross-sectional, single-blind study was conducted between May and August 2025. An AI algorithm trained with 346 validated adult LC cases was tested live in 50 pediatric patients. Surgeries were transmitted in real time via teleconferencing to a second center where the algorithm processed the surgical image and identified CVS structures. Two expert surgeons, blinded to the algorithm, assessed CVS presence independently. RESULTS: A total of 50 patients (38 females and 12 males were classified as middle childhood to early adolescence) were included. The mean body mass index was 29.3+/-5.8. CVS was detected fully in 37 cases. In 13 cases, one or more elements were absent. Agreement between the algorithm and surgeons assessments was 100%. No postoperative complications were reported. CONCLUSION: Remote AI-assisted CVS detection in pediatric LC is feasible, safe and consistent with expert evaluation. CI - Copyright (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Olivieri, Sean Exequiel AU - Olivieri SE AUID- ORCID: 0009-0007-3658-0499 AD - General Surgery, Hospital General de Agudos Dr. Cosme Argerich, Buenos Aires, Argentina. AD - Digestive Surgery, Hospital de Gastroenterologia Dr. Carlos Bonorino Udaondo, Buenos Aires, Argentina. FAU - Darrigran, Santiago AU - Darrigran S AD - Pediatric Surgery, San Justo Children's Hospital, Buenos Aires, Argentina. FAU - Petracchi, Enrique AU - Petracchi E AD - General Surgery, Hospital General de Agudos Dr. Cosme Argerich, Buenos Aires, Argentina. FAU - Bidone, Paula AU - Bidone P AD - Pediatric Surgery, San Justo Children's Hospital, Buenos Aires, Argentina. FAU - Perez, Anahi AU - Perez A AD - Pediatric Surgery, San Justo Children's Hospital, Buenos Aires, Argentina. FAU - Cardozo, Leandro AU - Cardozo L AD - Pediatric Surgery, San Justo Children's Hospital, Buenos Aires, Argentina. FAU - Fernandez, Melissa AU - Fernandez M AD - Pediatric Surgery, San Justo Children's Hospital, Buenos Aires, Argentina. FAU - Zandalazini, Hugo AU - Zandalazini H AD - General Surgery, Hospital General de Agudos Dr. Cosme Argerich, Buenos Aires, Argentina. FAU - Della Pia, Ignacio AU - Della Pia I AD - Pediatric Surgery, San Justo Children's Hospital, Buenos Aires, Argentina. LA - eng PT - Journal Article DEP - 20260201 PL - England TA - World J Pediatr Surg JT - World journal of pediatric surgery JID - 101761337 PMC - PMC12863403 OTO - NOTNLM OT - Adolescent Health OT - Data Collection OT - Education, Medical OT - Evidence-Based Medicine OT - Health services research COIS- None declared. EDAT- 2026/02/04 11:33 MHDA- 2026/02/04 11:34 PMCR- 2026/02/01 CRDT- 2026/02/04 04:11 PHST- 2025/10/23 00:00 [received] PHST- 2026/01/06 00:00 [accepted] PHST- 2026/02/04 11:34 [medline] PHST- 2026/02/04 11:33 [pubmed] PHST- 2026/02/04 04:11 [entrez] PHST- 2026/02/01 00:00 [pmc-release] AID - wjps-2025-001125 [pii] AID - 10.1136/wjps-2025-001125 [doi] PST - epublish SO - World J Pediatr Surg. 2026 Feb 1;9(1):e001125. doi: 10.1136/wjps-2025-001125. eCollection 2026. PMID- 41635807 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260902 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Effect of swallowing related fatigue on eating and drinking behaviors across the age spectrum. PG - e20349 LID - 10.7717/peerj.20349 [doi] LID - e20349 AB - BACKGROUND: Swallowing related fatigue refers to the decline in swallowing efficiency and safety due to sustained muscular effort over time. It can significantly impact eating and drinking behaviors, potentially leading to aspiration, malnutrition and diminished quality of life. Understanding the effects of swallowing fatigue across the age spectrum can help guide clinical interventions and management strategies. Hence, this study aims to evaluate the effects of swallowing-related fatigue on eating and drinking behaviors in young, middle-aged and older adults. METHODS: A cross-sectional study was conducted, recruiting 400 healthy individuals divided into three groups consisting of young adults, middle-aged adults and older adults. Participants with speech, language, swallowing, neurological, or cognitive impairments were excluded. The study utilized standardized assessments, including the Swallowing and Eating-Related Fatigue Scale (SERF) to measure swallowing fatigue. Objective swallowing function was evaluated using the Timed Water Swallow Test (TWST) for liquid intake, the Test of Masticating and Swallowing Solids (TOMASS) for solid food consumption, and the Mealtime Assessment Scale (MAS) to assess overall mealtime behaviors. Video recordings of swallowing tasks were analyzed to measure efficiency, speed, and fatigue-related changes. RESULTS: Swallowing fatigue was significantly higher in older adults compared to middle-aged and young adults. TWST results showed that older adults exhibited longer swallowing durations, smaller bolus volumes per swallow, and reduced swallowing efficiency, though correlations between TWST parameters and fatigue were weak. In contrast, TOMASS scores revealed moderate associations with swallowing fatigue, as older adults took more bites, had longer mastication durations, and required more swallows per bolus. MAS scores demonstrated moderate to strong correlations with swallowing fatigue across all age groups, indicating that individuals experiencing higher fatigue levels displayed compromised mealtime efficiency and safety. Reliability analyses confirmed excellent test-retest reliability for TWST & TOMASS, with good to excellent interrater reliability. CONCLUSION: This study underscores the impact of swallowing-related fatigue on eating and drinking behaviors, particularly among older adults. While swallowing fatigue had minimal to moderate influence on TWST and TOMASS parameters respectively, MAS demonstrated stronger associations, suggesting that swallowing endurance plays a critical role in overall mealtime performance. These findings highlight the importance of integrating fatigue assessments into clinical dysphagia evaluations, as fatigue-related impairments may increase the risk of nutritional deficits and aspiration. Future research should focus on developing interventions to mitigate swallowing fatigue and improve mealtime efficiency, particularly in aging & clinical populations. CI - (c)2026 Chilwan et al. FAU - Chilwan, Uzair AU - Chilwan U AD - Department of Audiology & Speech Language Pathology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India. FAU - Kumar, K Vijaya AU - Kumar KV AD - Department of Physiotherapy, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India. FAU - Karuppali, Sudhin AU - Karuppali S AD - School of Rehabilitation and Medical Sciences, College of Health Sciences, University of Nizwa, Nizwa, Sultanate of Oman, Nizwa, Oman. FAU - Aithal, Venkataraja U AU - Aithal VU AD - Department of Speech & Hearing, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, India. FAU - Balasubramanium, Radish Kumar AU - Balasubramanium RK AD - Department of Audiology & Speech Language Pathology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India. LA - eng PT - Journal Article DEP - 20260130 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - *Deglutition/physiology MH - *Fatigue/diagnosis/physiopathology MH - *Drinking Behavior/physiology MH - *Feeding Behavior/physiology MH - Age Factors MH - Cross-Sectional Studies MH - Aging/physiology MH - *Deglutition Disorders/complications/diagnosis/physiopathology MH - Video Recording MH - Time Factors MH - Respiratory Aspiration/etiology/physiopathology/prevention & control MH - Malnutrition/etiology/physiopathology/prevention & control MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged PMC - PMC12863145 OTO - NOTNLM OT - Drinking OT - Eating OT - Fatigue OT - Mealtime OT - Older adults OT - SERF OT - Swallowing COIS- The authors declare there are no competing interests. EDAT- 2026/02/04 11:32 MHDA- 2026/02/04 11:33 PMCR- 2026/01/30 CRDT- 2026/02/04 04:11 PHST- 2025/02/21 00:00 [received] PHST- 2025/10/15 00:00 [accepted] PHST- 2026/02/04 11:33 [medline] PHST- 2026/02/04 11:32 [pubmed] PHST- 2026/02/04 04:11 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - 20349 [pii] AID - 10.7717/peerj.20349 [doi] PST - epublish SO - PeerJ. 2026 Jan 30;14:e20349. doi: 10.7717/peerj.20349. eCollection 2026. PMID- 41634814 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 2072-1315 (Electronic) IS - 1606-0997 (Print) IS - 1606-0997 (Linking) VI - 45 IP - 1 DP - 2026 Feb 3 TI - Validity and reliability of a scale of activities of daily living at home in children, youth and adults with Down syndrome in Chile. LID - 10.1186/s41043-025-01227-0 [doi] LID - 81 AB - BACKGROUND: Activities of daily living at home (ADL) are a fundamental aspect of adaptive behavior in children, youth, and adults with Down syndrome (DS). However, they have received limited attention in relation to this topic. This highlights the lack of a validated instrument for the DS population in Chile. OBJECTIVE: a) Verify validity and reliability of the Scale for Assessing of Daily Living at Home (SAADL) and b) Develop benchmarks for daily activities in children, young people, and adults with DS in central-southern Chile. METHODS: A descriptive cross-sectional study was conducted in children, youth and adults with DS in Chile. A total of 320 young people (168 males and 152 females) with an age range of 6 to 29 years were recruited. Weight and height were assessed and body mass index BMI was calculated. The SAADL was used to measure activities of daily living at home. Reliability was determined by stability measures (test and retest) and validity by confirmatory factor analysis (CFA). Percentiles were constructed using the LMS technique (L(t) Box-Cox power, M(t) median and S(t) coefficient of variation). RESULTS: In both sexes, the technical error of measurement (TEM) showed very low values, with an absolute error of less than 0.23 and a relative error of 0.85%. The values of the concordance correlation coefficient showed high values of precision and accuracy from 0.94 to 0.98. The Kappa analysis showed substantial agreement values from 0.73 to 0.78. Mean differences in the Bland-Altman plot were minimal (~0.32 to ~0.56 points). The CFA demonstrated the validity of the scale (RMSEA: 0.057). Percentiles were plotted for SAADL (p5, p10, p15, p25, p50, p75, p85, p90 and p95). CONCLUSION: The study confirms that the SAADL is highly valid and reliable for assessing activities of daily living in children, youth and adults with DS in the south-central region of Chile. Its use is recommended as an effective tool for clinical assessment, early intervention and personalization of care, based on the proposed reference values. CI - (c) 2026. The Author(s). FAU - Cossio-Bolanos, Marco AU - Cossio-Bolanos M AD - Universidad Catolica del Maule, Talca, Chile. mcossio1972@hotmail.com. AD - Faculty of Education, Psychology and Sport Sciences, University of Huelva, Huelva, Spain. mcossio1972@hotmail.com. FAU - Vidal-Espinoza, Ruben AU - Vidal-Espinoza R AD - Universidad Catolica Silva Henriquez, Santiago, Chile. FAU - Mendez-Mendez, Liliam AU - Mendez-Mendez L AD - Universidad Catolica del Maule, Talca, Chile. FAU - Sulla-Torres, Jose AU - Sulla-Torres J AD - Universidad Catolica de Santa Maria, Arequipa, Peru. FAU - Urra-Albornoz, Camilo AU - Urra-Albornoz C AD - Departamento Ciencias de la Educacion, Facultad de Educacion y Humanidades, Universidad del Bio Bio, Chillan, Chile. FAU - Urzua-Alul, Luis AU - Urzua-Alul L AD - Escuela de Kinesiologia, Facultad de Salud, Universidad Santo Tomas, Talca, Chile. FAU - de Campos, Luis Felipe Castelli Correia AU - de Campos LFCC AD - Universidad Adventista de Chile, Chillan, Chile. FAU - Gomez-Campos, Rossana AU - Gomez-Campos R AD - Universidad Catolica del Maule, Talca, Chile. rossaunicamp@gmail.com. AD - Faculty of Education, Psychology and Sport Sciences, University of Huelva, Huelva, Spain. rossaunicamp@gmail.com. LA - eng GR - 1241104/Fondecyt Regular/ PT - Journal Article PT - Validation Study DEP - 20260203 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 SB - IM MH - Humans MH - *Activities of Daily Living MH - Chile MH - Female MH - *Down Syndrome/psychology/physiopathology MH - Child MH - Male MH - Reproducibility of Results MH - Adolescent MH - Cross-Sectional Studies MH - Adult MH - Young Adult MH - Body Mass Index MH - Surveys and Questionnaires/standards PMC - PMC12955063 OTO - NOTNLM OT - Activities of daily living OT - Down sindrome OT - Psychometric properties OT - Validation COIS- Declarations. Ethics approval and consent to participate: The study protocol was approved by the University Ethics Committee (UCM-65-2024). All experiments were conducted in accordance with relevant guidelines and regulations (such as the Declaration of Helsinki). Parents and guardians gave written informed consent for their children to participate in the study. All experiments were conducted in accordance with relevant guidelines and regulations (such as the Declaration of Helsinki). Competing interests: The authors declare no competing interests. EDAT- 2026/02/04 05:06 MHDA- 2026/03/07 01:37 PMCR- 2026/02/03 CRDT- 2026/02/03 23:58 PHST- 2025/05/26 00:00 [received] PHST- 2025/12/26 00:00 [accepted] PHST- 2026/03/07 01:37 [medline] PHST- 2026/02/04 05:06 [pubmed] PHST- 2026/02/03 23:58 [entrez] PHST- 2026/02/03 00:00 [pmc-release] AID - 10.1186/s41043-025-01227-0 [pii] AID - 1227 [pii] AID - 10.1186/s41043-025-01227-0 [doi] PST - epublish SO - J Health Popul Nutr. 2026 Feb 3;45(1):81. doi: 10.1186/s41043-025-01227-0. PMID- 41634662 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-244X (Electronic) IS - 1471-244X (Linking) VI - 26 IP - 1 DP - 2026 Feb 3 TI - Cytokines and adolescent anorexia nervosa: a case-control study. LID - 10.1186/s12888-026-07874-9 [doi] LID - 223 AB - BACKGROUND: Anorexia nervosa (AN) represents a relatively common eating disorder associated with the highest mortality from all mental disorders. However, the underlying AN psychobiology remains unclear. The disruption in immune pathways seems to play an important pathophysiological role in AN. Therefore, this study aimed to evaluate the cytokine profile in association with assessing the pro-inflammatory/anti-inflammatory balance in drug-naive adolescent AN girls in the early stage of the disease. METHODS: Selected cytokines including interleukin (IL)-1alpha, IL-1beta, IL-2, IL-4, IL-6, IL-8, IL-10, interferon-gamma, tumor necrosis factor-alpha (TNF-alpha) were evaluated in 35 adolescent AN girls (mean age: 15.0 +/- 1.6 years) and 25 age-matched control adolescent girls (mean age: 15.9 +/- 1.5 years). Moreover, selected cytokine profiles and cytokine ratios were calculated to evaluate the pro-inflammatory/anti-inflammatory balance in adolescent AN. The presence and severity of depressive symptomatology were evaluated by full-filling the standardized and validated Children s Depression Inventory. RESULTS: The plasma levels of IL-1beta, IL-6, TNF-alpha, M1 profile, pro-inflammatory profile, Th1/Th2 ratio, Th1/Treg ratio, Th1/Th2 + Treg ratio, and pro-inflammatory/anti-inflammatory ratio were significantly higher in AN adolescent girls compared to controls (p = 0.002, p = 0.009, p = 0.031, p < 0.001, p = 0.042, p = 0.031, p = 0.021, p = 0.016, p = 0.001; respectively). On the other hand, the plasma level of IL-1alpha was significantly lower in AN adolescent girls compared to controls (p = 0.005). Moreover, BMI predicted levels of IL-4 and IL-1beta (p = 0.009, p = 0.046, respectively), and depressive symptomatology predicted level of IL-8 (p = 0.012) in adolescent AN girls. Lastly, ROC analysis revealed a certain predictive value of significantly changed cytokines, cytokine profiles, and ratios in adolescent AN, which markedly improved by the combination of these parameters (AUC = 0.930). Moreover, cross-validation analysis of the combined model AUC using the K-Nearest Neighbors model achieved a high overall accuracy of 0.917 for both groups, with a precision of 1.000 for the AN and 0.800 for the controls. CONCLUSIONS: Adolescent drug-naive AN in early stages of the disease is characterized by enhanced IL-1beta, IL-6, and TNF-alpha signalling indicating the activation of pro-inflammatory response system. Whether these inflammatory abnormalities are AN-specific or related to other confounding aspects of the disease still needs to be resolved, since BMI and depressive symptomatology contributed to the alterations in evaluated inflammatory markers in this study. CLINICAL TRIAL NUMBER: Not applicable. FAU - Ferencova, Nikola AU - Ferencova N AD - Department of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4C, Martin, Slovak Republic. AD - Biomedical Centre Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4D, Martin, Slovak Republic. FAU - Visnovcova, Zuzana AU - Visnovcova Z AD - Biomedical Centre Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4D, Martin, Slovak Republic. FAU - Ondrejka, Igor AU - Ondrejka I AD - Psychiatric Clinic, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, University Hospital Martin, Kollarova 2, Martin, Slovak Republic. FAU - Hrtanek, Igor AU - Hrtanek I AD - Psychiatric Clinic, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, University Hospital Martin, Kollarova 2, Martin, Slovak Republic. FAU - Funakova, Dana AU - Funakova D AD - Psychiatric Clinic, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, University Hospital Martin, Kollarova 2, Martin, Slovak Republic. FAU - Tonhajzerova, Ingrid AU - Tonhajzerova I AD - Department of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4C, Martin, Slovak Republic. ingrid.tonhajzerova@uniba.sk. LA - eng GR - VEGA 1/0048/24/Ministerstvo skolstva, vedy, vyskumu a sportu Slovenskej republiky/ PT - Journal Article DEP - 20260203 PL - England TA - BMC Psychiatry JT - BMC psychiatry JID - 100968559 RN - 0 (Cytokines) RN - 0 (Tumor Necrosis Factor-alpha) SB - IM MH - Humans MH - *Anorexia Nervosa/blood/immunology MH - Female MH - Adolescent MH - *Cytokines/blood MH - Case-Control Studies MH - Depression/blood MH - Tumor Necrosis Factor-alpha/blood PMC - PMC12958572 OTO - NOTNLM OT - Adolescent age OT - Anorexia nervosa OT - Cytokines OT - Depressive symptomatology OT - Pro-inflammatory/anti-inflammatory balance COIS- Declarations. Ethical approval: This study was approved by the Ethics Committee of the Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava in accordance (EK69/2018) with the Declaration of Helsinki (2000) of the World Medical Association. Consent to participate: Written informed consent to participate in the study was obtained from all participants (i.e. AN patients and controls) and their legal guardians. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/04 05:06 MHDA- 2026/06/27 06:46 PMCR- 2026/02/03 CRDT- 2026/02/03 23:49 PHST- 2025/06/20 00:00 [received] PHST- 2026/01/28 00:00 [accepted] PHST- 2026/06/27 06:46 [medline] PHST- 2026/02/04 05:06 [pubmed] PHST- 2026/02/03 23:49 [entrez] PHST- 2026/02/03 00:00 [pmc-release] AID - 10.1186/s12888-026-07874-9 [pii] AID - 7874 [pii] AID - 10.1186/s12888-026-07874-9 [doi] PST - epublish SO - BMC Psychiatry. 2026 Feb 3;26(1):223. doi: 10.1186/s12888-026-07874-9. PMID- 41634602 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2377 (Electronic) IS - 1471-2377 (Linking) VI - 26 IP - 1 DP - 2026 Feb 4 TI - Association of diet quality, dietary acid load and antioxidant index with migraine severity, disability, and duration: a cross-sectional study. LID - 10.1186/s12883-026-04690-2 [doi] LID - 153 AB - BACKGROUND: Migraine disproportionately affects women and may be modulated by dietary factors. This cross-sectional study investigated associations between diet quality (Alternative Healthy Eating Index, AHEI), dietary acid load (Net Endogenous Acid Production, NEAP), and dietary antioxidant capacity (Dietary Antioxidant Index, DAI) with migraine pain intensity, disability, and headache duration in Iranian women. METHODS: A total of 280 women aged 18-50 years with migraine (diagnosed per ICHD-3 criteria) were recruited from neurology clinics in Zanjan, Iran (August 2024-June 2025). Dietary intake was assessed using a validated 168-item food frequency questionnaire. AHEI, NEAP, and DAI scores were calculated and stratified into tertiles. Outcomes included pain intensity (Visual Analog Scale [VAS]: mild [1-3; reference], moderate [4-7], severe [8-10]), disability (Migraine Disability Assessment Scale [MIDAS]: none [0-5; reference], mild [6-10], moderate [11-20], severe [> 20]), and mean headache duration (hours). Multivariable-adjusted multinomial logistic regression (for VAS and MIDAS) and linear regression (for duration) were used to estimate odds ratios (ORs) and beta coefficients with 95% confidence intervals (CIs), comparing the middle (T2) and highest (T3) tertiles versus the lowest (T1; reference), adjusted for age, BMI, physical activity, prophylactic medication use, and socioeconomic status. P-for-trend was calculated using tertile medians as continuous variables. RESULTS: Higher AHEI tertiles showed graded protective associations with severe pain (T3 OR 0.69, 95% CI 0.51-0.89, p = 0.010; P-for-trend = 0.009) and shorter headache duration (T3 beta - 1.58, 95% CI - 2.75 to - 0.41, p = 0.009; P-for-trend = 0.008). Higher NEAP tertiles were linked to increased severe pain (T3 OR 1.38, 95% CI 1.08-1.66, p = 0.021; P-for-trend = 0.018), severe disability (T3 OR 1.29, 95% CI 1.02-1.56, p = 0.044; P-for-trend = 0.039), and longer duration (T3 beta 1.28, 95% CI 0.25-2.31, p = 0.015; P-for-trend = 0.013). Higher DAI tertiles demonstrated the strongest graded reductions in moderate pain (T3 OR 0.59, 95% CI 0.41-0.83, p = 0.035; P-for-trend = 0.012), severe pain (T3 OR 0.47, 95% CI 0.33-0.74, p = 0.024; P-for-trend = 0.007), moderate disability (T3 OR 0.73, 95% CI 0.52-0.97, p = 0.048; P-for-trend = 0.031), severe disability (T3 OR 0.69, 95% CI 0.47-0.91, p = 0.038; P-for-trend = 0.022), and shorter duration (T3 beta - 1.34, 95% CI - 2.33 to - 0.35, p = 0.008; P-for-trend = 0.006). CONCLUSIONS: Better diet quality and higher antioxidant capacity were associated with reduced migraine burden, while higher dietary acid load correlated with increased burden. These findings highlight potential graded associations and support the need for prospective studies to establish causality and evaluate dietary interventions in women with migraine. FAU - Hashemi, Reza AU - Hashemi R AD - Department of Pharmacy, College of Pharmacy, Knowledge University, Erbil, 44001, Iraq. FAU - Kakhki, Simin Khayatzadeh AU - Kakhki SK AD - Division of Pediatric Neurology, School of Medicine, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. FAU - Khalid, Hawzhin AU - Khalid H AD - Department of Pharmacy, College of Pharmacy, Knowledge University, Erbil, 44001, Iraq. AD - Medical Lab Technology Department, Kalar Technical College, Garmian Polytechnic University, Kifri, Sulaimaniyah, Iraq. FAU - Ghalishourani, Samira Sadat AU - Ghalishourani SS AD - Department of Physical Education and Sport Sciences, Science of Research Branch, Islamic Azad University, Tehran, Iran. FAU - Feyzpour, Marzieh AU - Feyzpour M AD - Faculty of Medical Sciences, Islamic Azad University, Science and Research Branch, Tehran, Iran. FAU - Ansari, Samaneh AU - Ansari S AD - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. FAU - Gandomkar, Hossein AU - Gandomkar H AD - Department of Surgical Oncology, Tehran University of Medical Sciences, Tehran, Iran. samscigroup@gmail.com. FAU - Raouf, Mohammed M Hussien M AU - Raouf MMHM AD - Department of Biology, Faculty of Science and Health, Koya University, Koya, Kurdistan Region - F.R., 44023, Iraq. mohammed.m.hussein@cihanuniversity.edu.iq. LA - eng PT - Journal Article DEP - 20260204 PL - England TA - BMC Neurol JT - BMC neurology JID - 100968555 RN - 0 (Antioxidants) RN - 0 (Acids) SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - *Antioxidants/metabolism MH - *Migraine Disorders/epidemiology/physiopathology MH - Adult MH - Middle Aged MH - Iran/epidemiology MH - *Diet MH - Severity of Illness Index MH - Adolescent MH - Young Adult MH - Disability Evaluation MH - *Acids/metabolism MH - *Diet, Healthy PMC - PMC12964964 OTO - NOTNLM OT - Antioxidant index OT - Cross-Sectional study OT - Diet quality OT - Dietary acid load OT - Iran OT - Migraine OT - Women COIS- Declarations. Ethics approval and consent to participate: All methods were performed in accordance with the Declaration of Helsinki guidelines and regulations. The study protocol received approval from the Ethics Committee of Zanjan University of Medical Sciences (IR.ZUMS.REC.1403.041). Prior to participation, all individuals provided written informed consent, affirming their voluntary participation after being fully informed about the study's purpose, methodology, potential risks, and benefits. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/04 05:06 MHDA- 2026/06/27 22:35 PMCR- 2026/02/04 CRDT- 2026/02/03 23:46 PHST- 2025/10/03 00:00 [received] PHST- 2026/01/28 00:00 [accepted] PHST- 2026/06/27 22:35 [medline] PHST- 2026/02/04 05:06 [pubmed] PHST- 2026/02/03 23:46 [entrez] PHST- 2026/02/04 00:00 [pmc-release] AID - 10.1186/s12883-026-04690-2 [pii] AID - 4690 [pii] AID - 10.1186/s12883-026-04690-2 [doi] PST - epublish SO - BMC Neurol. 2026 Feb 4;26(1):153. doi: 10.1186/s12883-026-04690-2. PMID- 41634056 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Feb 3 TI - AI based sagittal spinal posture assessment for adolescent screening in low resource school settings. PG - 7076 LID - 10.1038/s41598-026-36634-8 [doi] LID - 7076 AB - Adolescent spinal postural deviations are rising across Southeast Asia, driven by prolonged screen exposure and limited access to clinical screening in low-resource environments. To address this gap, we developed PostureGuard, a low-cost AI system that provides real-time posture assessment and school-based screening support. The system incorporates a Southeast Asia-calibrated pose estimation model, benchmarked against radiographic references and validated using wearable sensor measurements. In a field deployment involving 200 students across 15 Indonesian schools, PostureGuard achieved a mean absolute error below 2.3 degrees for forward head angle estimation. We further identified a dose-response association in which each additional hour of daily screen time was associated with an estimated 2.1 degrees increase in forward head angle. A preliminary six-month school implementation suggested improvements in posture-related indicators; however, these observations were not derived from a controlled clinical trial. PostureGuard has since been piloted within Indonesia's 2024 Digital Wellness Mandate initiative. This work presents a regionally calibrated AI-based posture screening framework with clinical benchmarking and demonstrated scalability for adolescent spinal health monitoring in resource-limited settings. CI - (c) 2026. The Author(s). FAU - Rahman, Ben AU - Rahman B AD - Department of Information Systems, Universitas Nasional, Jakarta, 12520, Indonesia. benrahman@civitas.unas.ac.id. FAU - Sutedja, Indrajani AU - Sutedja I AD - Information Systems Department, School of Information Systems, Bina Nusantara University, Jakarta, 11480, Indonesia. LA - eng PT - Journal Article DEP - 20260203 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Posture/physiology MH - Schools MH - Adolescent MH - *Spine/physiology MH - *Artificial Intelligence MH - Female MH - Male MH - Indonesia MH - *Mass Screening/methods PMC - PMC12921215 OTO - NOTNLM OT - Adolescent OT - Artificial Intelligence OT - Kyphosis OT - Posture OT - Spine COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval: Not applicable. EDAT- 2026/02/04 05:06 MHDA- 2026/02/20 00:32 PMCR- 2026/02/03 CRDT- 2026/02/03 23:19 PHST- 2025/08/26 00:00 [received] PHST- 2026/01/14 00:00 [accepted] PHST- 2026/02/20 00:32 [medline] PHST- 2026/02/04 05:06 [pubmed] PHST- 2026/02/03 23:19 [entrez] PHST- 2026/02/03 00:00 [pmc-release] AID - 10.1038/s41598-026-36634-8 [pii] AID - 36634 [pii] AID - 10.1038/s41598-026-36634-8 [doi] PST - epublish SO - Sci Rep. 2026 Feb 3;16(1):7076. doi: 10.1038/s41598-026-36634-8. PMID- 41632554 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260827 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 1 DP - 2026 Mar TI - Improving Child Malnutrition Estimates in Bangladesh: The Role of Data Quality in Anthropometric Measures Using DHS 2014-2022. PG - e70161 LID - 10.1111/mcn.70161 [doi] LID - e70161 AB - Reliable anthropometric data are essential for tracking child malnutrition, yet such data are prone to measurement errors, particularly in large-scale surveys conducted in resource-limited settings. This study assesses the quality of anthropometric data in the Bangladesh Demographic and Health Surveys (BDHS) from 2014, 2018, and 2022, focusing on how different data filtering approaches affect malnutrition estimates. We analyzed data from children aged 6-59 months using the BDHS children's recode files. Data quality was assessed using WHO-defined thresholds for biologically implausible values and SMART plausibility criteria, which exclude values beyond +/-3.1 standard deviations from the sample mean. Additional checks included z-score distribution properties, digit preference scores (DPS), and demographic consistency measures. Prevalence of stunting, underweight, and wasting was calculated before and after data filtering, with subgroup analyses by age, household wealth, and family size. SMART flagging excluded about 12% of records per round-substantially more than WHO thresholds. Stunting and underweight estimates remained broadly stable over time, while wasting prevalence dropped by 1.5-2.5 percentage points post-flagging, reflecting sensitivity of prevalence to filtering thresholds. Children aged 6-23 months were more frequently flagged. A steady decline in digit preference scores suggested improved measurement consistency, though variability persisted by socioeconomic group. Overall, BDHS anthropometric data showed stable internal patterns across survey rounds rather than conclusive reliability. These findings are presented as scenario analyses comparing WHO and SMART filters, illustrating how methodological choices influence malnutrition estimates. Strengthening field protocols-particularly for weight-for-height among younger children-could further enhance data precision and comparability. CI - (c) 2026 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Ahmed, Khandaker Tanveer AU - Ahmed KT AUID- ORCID: 0000-0001-7326-024X AD - BRAC Bank PLC, Tejgaon, Dhaka, Bangladesh. FAU - Alam, Muhammad Khairul AU - Alam MK AUID- ORCID: 0000-0002-4803-2648 AD - Department of Statistics and Data Science, Jahangirnagar University, Savar, Dhaka, Bangladesh. LA - eng PT - Journal Article PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - Bangladesh/epidemiology MH - Infant MH - Child, Preschool MH - *Child Nutrition Disorders/epidemiology MH - Female MH - *Anthropometry/methods MH - Male MH - Prevalence MH - Thinness/epidemiology MH - *Data Accuracy MH - Wasting Syndrome/epidemiology MH - *Health Surveys MH - Secondary Data Analysis MH - Growth Disorders/epidemiology PMC - PMC12867088 OTO - NOTNLM OT - Bangladesh OT - DHS OT - SMART flagging OT - anthropometry OT - child nutrition OT - data quality OT - malnutrition COIS- The authors declare no conflicts of interest. EDAT- 2026/02/03 21:37 MHDA- 2026/02/03 21:38 PMCR- 2026/02/03 CRDT- 2026/02/03 12:23 PHST- 2025/10/10 00:00 [revised] PHST- 2025/05/06 00:00 [received] PHST- 2026/01/08 00:00 [accepted] PHST- 2026/02/03 21:38 [medline] PHST- 2026/02/03 21:37 [pubmed] PHST- 2026/02/03 12:23 [entrez] PHST- 2026/02/03 00:00 [pmc-release] AID - MCN70161 [pii] AID - 10.1111/mcn.70161 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Mar;22(1):e70161. doi: 10.1111/mcn.70161. PMID- 41630495 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260706 IS - 1440-1754 (Electronic) IS - 1034-4810 (Linking) VI - 62 IP - 4 DP - 2026 Apr TI - Dietary Beliefs, Food Avoidance and Meal Skipping in Australian Children With Inflammatory Bowel Disease. PG - 579-585 LID - 10.1111/jpc.70301 [doi] AB - OBJECTIVES: To determine the frequency and patterns of dietary modification, sources of dietary advice and associated behaviours in Australian children with inflammatory bowel disease (IBD). METHODS: Mixed-methods cross-sectional study was conducted with IBD patients attending Perth Children's Hospital. Participants completed a validated questionnaire and clinical disease activity (PUCAI/PCDAI) was recorded on the day of consultation. Descriptive statistics, t-tests, chi-square tests, and multivariable logistic regressions were performed using Jamovi. RESULTS: Sixty-four children participated (34 males; mean age 13.4 +/- 2.8 years; 28 Crohn's disease, 36 ulcerative colitis). Over half (33/64, 51.6%) reported dietary modification post diagnosis, most commonly food avoidance. One-third (24/64, 37.5%) regularly skipped meals. On multivariable logistics regression food avoidance (aOR 13.8, 95% CI 2.17-87) and disease activity (aOR 12.4, 95% CI 2.80-55.1) were independently associated with meal skipping. Females were 3.17 (95% CI 1.14-8.80) times more likely to practice food avoidance and 3.56 (95% CI 1.14-8.80) times more likely to report symptom exacerbation with specific foods on univariable analysis. Although gastroenterologists and dietitians were the most trusted sources of dietary advice, over 20% (7/33) of patients were modifying their diet based on non-expert recommendation. CONCLUSIONS: Dietary modification post diagnosis is prevalent among Australian paediatric IBD patients. Meal skipping is independently associated with active disease and self-directed food avoidance; females report higher rates of food avoidance and symptoms exacerbation with foods. These findings highlight the need for proactive, consistent dietary counselling and underscore the importance of further multicentre studies to corroborate these findings. CI - (c) 2026 Paediatrics and Child Health Division (The Royal Australasian College of Physicians). FAU - Gammanpila, Dewruwan AU - Gammanpila D AUID- ORCID: 0009-0008-1036-1922 AD - Department of Gastroenterology, Perth Children's Hospital, Perth, Australia. AD - University of Western Australia, Perth, Australia. FAU - Collins, Tanya AU - Collins T AD - Nutrition and Dietetics, Perth Children's Hospital, Perth, Australia. FAU - Grover, Zubin AU - Grover Z AUID- ORCID: 0000-0002-5925-4166 AD - Department of Gastroenterology, Perth Children's Hospital, Perth, Australia. AD - University of Western Australia, Perth, Australia. LA - eng PT - Journal Article DEP - 20260202 PL - Australia TA - J Paediatr Child Health JT - Journal of paediatrics and child health JID - 9005421 SB - IM MH - Humans MH - Female MH - Male MH - Adolescent MH - Cross-Sectional Studies MH - Child MH - Australia MH - *Inflammatory Bowel Diseases/psychology MH - Surveys and Questionnaires MH - *Feeding Behavior/psychology MH - Intermittent Fasting MH - *Health Knowledge, Attitudes, Practice OTO - NOTNLM OT - adolescent nutrition disorders OT - avoidant restrictive food intake disorder OT - feeding behaviour OT - food preferences OT - paediatric inflammatory bowel disease EDAT- 2026/02/03 07:40 MHDA- 2026/04/02 12:36 CRDT- 2026/02/03 02:32 PHST- 2026/01/13 00:00 [revised] PHST- 2025/11/30 00:00 [received] PHST- 2026/01/19 00:00 [accepted] PHST- 2026/04/02 12:36 [medline] PHST- 2026/02/03 07:40 [pubmed] PHST- 2026/02/03 02:32 [entrez] AID - 10.1111/jpc.70301 [doi] PST - ppublish SO - J Paediatr Child Health. 2026 Apr;62(4):579-585. doi: 10.1111/jpc.70301. Epub 2026 Feb 2. PMID- 41630242 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260706 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 5 DP - 2026 Jan 30 TI - Research on children's health prediction based on Improved Grey Wolf Optimization algorithm-Random Forest model. PG - e47430 LID - 10.1097/MD.0000000000047430 [doi] LID - e47430 AB - Children's health is a crucial indicator for evaluating public health standards and social development. With the changes in lifestyles and the increasing complexity of environmental factors, health issues such as childhood obesity, allergic diseases, and respiratory infections have become increasingly prominent. Traditional health assessment methods that rely on periodic physical examinations and questionnaires have limitations such as data lag and subjectivity. This paper proposes a hybrid model (IGWO-RF) that integrates the Improved Grey Wolf Optimization (IGWO) algorithm with Random Forest (RF) to enhance parameter optimization and interpretability in pediatric health prediction. Firstly, a RF prediction model is constructed based on children's physical examination data. Secondly, dynamic weight strategy and elite retention mechanisms are introduced to improve the Grey Wolf algorithm for optimizing RF hyperparameters. The model uses Shapley Additive Explanations (SHAP) values to interpret key factors affecting health. Experimental results show that the IGWO-RF model achieves an accuracy of 92.1% and a F1-score of 90.8%, which significantly outperforms the traditional RF model (85.3%) and the particle swarm optimization-RF model (88.7%). SHAP value analysis identifies body mass index (contribution value 0.32), daily exercise time (0.21), and particulate matter 2.5 exposures (0.18) as the top 3 determinants of children's health. It should be noted that these associations reflect the model's feature importance based on SHAP values and do not imply causal inference. The IGWO-RF model is potentially useful for children's health risk stratification, pending external validation, with excellent predictive performance, and its methodological framework can be extended to early warning systems for other chronic diseases after further testing. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Xu, Huan AU - Xu H AUID- ORCID: 0000-0003-1674-3557 AD - Department of Public Teaching, Hefei Preschool Education College, Hefei, China. FAU - Hu, Junying AU - Hu J AD - School of Economics and Management, Hefei University, Hefei, PR China. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Random Forest MH - Humans MH - Prediction Algorithms MH - *Algorithms MH - Child MH - *Child Health MH - Body Mass Index MH - Particle Swarm Optimization MH - Soft Computing PMC - PMC12863868 OTO - NOTNLM OT - Grey Wolf Optimization OT - Random Forest OT - children's health prediction OT - healthcare analytics OT - machine learning COIS- The authors have no conflicts of interest to disclose. EDAT- 2026/02/03 07:40 MHDA- 2026/02/03 07:41 PMCR- 2026/01/30 CRDT- 2026/02/03 01:00 PHST- 2025/08/21 00:00 [received] PHST- 2025/12/17 00:00 [accepted] PHST- 2026/02/03 07:41 [medline] PHST- 2026/02/03 07:40 [pubmed] PHST- 2026/02/03 01:00 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - 00005792-202601300-00044 [pii] AID - MD-D-25-10690 [pii] AID - 10.1097/MD.0000000000047430 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Jan 30;105(5):e47430. doi: 10.1097/MD.0000000000047430. PMID- 41629834 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Feb 2 TI - The adjunctive effect of a qigong (Baduanjin) intervention program on maternal and child health outcomes: a multicenter randomized controlled trial protocol. LID - 10.1186/s12884-026-08714-0 [doi] LID - 218 AB - INTRODUCTION: Lifestyle interventions are critical for optimizing maternal and child health outcomes during pregnancy. As a mind-body exercise rooted in the principles of traditional Chinese Medicine (TCM), qigong shows promise as adaptable prenatal interventions, but the evidence is limited. OBJECTIVE: This multicenter randomized controlled trial (RCT) protocol aims to evaluate the additive effect of a qigong intervention program, compared to routine lifestyle intervention alone, on reducing the rate of caesarean section (primary outcome) and improving a range of secondary maternal and child health outcomes. METHODS: This multicenter RCT will be conducted across 11 institutions in China. A total of 1062 participants aged 18-45 years, with singleton pregnancies at 11-13(+ 6) weeks of gestation, will be enrolled and randomly allocated to two groups using a central stratified block randomization method. Participants will be randomized to either a control group receiving standard prenatal care plus evidence-based lifestyle education (encompassing nutrition, physical activity, sleep hygiene, stress management, and environmental avoidance), or an intervention group receiving all control components supplemented with supervised pregnancy-adapted qigong intervention (a modified seated Baduanjin exercise program). The primary outcome is caesarean section rate. Secondary outcomes include obstetric complications (abortion, preterm birth, gestational diabetes mellitus, gestational hypertension, postpartum hemorrhage, fetal growth restriction), neonatal indicators (birth weight, Apgar scores), maternal gestational weight gain, and mental health and sleep-related outcomes assessed through validated instruments such as Perceived Stress Scale-4 (PSS-4) for stress levels, Fear of Birth Scale (FOBS) for fear of childbirth, and Brief Pittsburgh Sleep Quality Index (B-PSQI) for sleep quality. CONCLUSION: This rigorously designed multicenter RCT protocol addresses a significant gap by investigating whether integrating the traditional mind-body practice of qigong into standard prenatal lifestyle education confers additional benefits for reducing cesarean sections and enhancing broader maternal-child health metrics. The findings will provide robust evidence on the clinical value of this TCM intervention in integrative prenatal care to improve pregnancy outcomes and maternal and child well-being. TRIAL REGISTRATION: This trial was registered at International Traditional Medicine Clinical Trial Registry, ITMCTR2025002612. CI - (c) 2026. The Author(s). FAU - Wang, Fangfang AU - Wang F AD - Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, 310006, China. AD - Institute of Medical Genetics and Development, Key Laboratory of Reproductive Genetics (Ministry of Education), Zhejiang University, Hangzhou, 310006, China. AD - Key Laboratory of Maternal and Infant Health, Hangzhou, 310006, China. AD - Linhai Branch, Women's Hospital, School of Medicine, Zhejiang University (Linhai Maternal and Child Health Hospital), Linhai, 317099, China. FAU - Zeng, Wenshan AU - Zeng W AD - Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, 310006, China. FAU - Zhou, Tianyi AU - Zhou T AD - Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, 310006, China. FAU - Yun, Feng AU - Yun F AD - Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, 310006, China. FAU - Li, Xinyue AU - Li X AD - Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, 310006, China. FAU - Li, Ying AU - Li Y AD - Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, 310006, China. FAU - Li, Hongyu AU - Li H AD - The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing, 400038, China. FAU - Huang, Yinying AU - Huang Y AD - Xiamen Maternal and Child Health Hospital, Xiamen, 361003, China. FAU - Yu, Dafang AU - Yu D AD - Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, 250001, China. FAU - Guo, Shengbin AU - Guo S AD - Fujian Maternal and Child Health Hospital, Fuzhou, 350001, China. FAU - Liu, Xiao AU - Liu X AD - Jiangxi Maternal and Child Health Hospital, Nanchang, 330006, China. FAU - Hu, Chunyan AU - Hu C AD - Maternal and Child Health Hospital of Inner Mongolia Autonomous Region, Hohhot, 010020, China. FAU - Zhou, Ju AU - Zhou J AD - Dalian Women and Children's Medical Center (group), Dalian, 116012, China. FAU - Fan, Longlong AU - Fan L AD - Aksu Prefecture Maternal and Child Health Hospital, Aksu, 843000, China. FAU - Ma, Lijuan AU - Ma L AD - Linhai Branch, Women's Hospital, School of Medicine, Zhejiang University (Linhai Maternal and Child Health Hospital), Linhai, 317099, China. FAU - Yu, Guizhen AU - Yu G AD - Dongguan Maternal and Child Health Hospital, Dongguan, 523000, China. FAU - Xie, Dawei AU - Xie D AD - Department of Biostatistics, Epidemiology and Informatics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, 227 Blockley Hall, 437 Guardian Drive, Philadelphia, PA 19104, Pennsylvania, USA. dxie@pennmedicine.upenn.edu. FAU - Xu, Xinfen AU - Xu X AD - Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, 310006, China. Xuxinf@zju.edu.cn. FAU - Qu, Fan AU - Qu F AD - Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, 310006, China. syqufan@zju.edu.cn. AD - Institute of Medical Genetics and Development, Key Laboratory of Reproductive Genetics (Ministry of Education), Zhejiang University, Hangzhou, 310006, China. syqufan@zju.edu.cn. AD - Key Laboratory of Maternal and Infant Health, Hangzhou, 310006, China. syqufan@zju.edu.cn. AD - Linhai Branch, Women's Hospital, School of Medicine, Zhejiang University (Linhai Maternal and Child Health Hospital), Linhai, 317099, China. syqufan@zju.edu.cn. LA - eng GR - no.2024YFC3505800/National Key Research and Development Program of China/ GR - no.81873837/National Natural Science Foundation of China/ GR - no.82575119/National Natural Science Foundation of China/ PT - Clinical Trial Protocol PT - Journal Article DEP - 20260202 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Qigong/methods MH - Adult MH - *Prenatal Care/methods MH - Multicenter Studies as Topic MH - Randomized Controlled Trials as Topic MH - *Cesarean Section/statistics & numerical data MH - Adolescent MH - China MH - Young Adult MH - *Pregnancy Complications/prevention & control MH - Middle Aged MH - *Child Health MH - Pregnancy Outcome PMC - PMC12952147 OTO - NOTNLM OT - Clinical trial OT - Lifestyle OT - Pregnancy OT - Protocol OT - Qigong COIS- Declarations. Ethics approval and consent to participate: This research protocol has been approved by the ethics committee of Women's Hospital, School of Medicine, Zhejiang University (No. IRB-20250451-R) and registered in the International Traditional Medicine Clinical Trial Registry, ITMCTR2025002612. Consent for publication: All participants will sign the Informed Consent Form, with authorization for deidentified data sharing. Competing interests: The authors declare no competing interests. EDAT- 2026/02/03 07:41 MHDA- 2026/03/07 01:37 PMCR- 2026/02/02 CRDT- 2026/02/03 00:06 PHST- 2026/01/06 00:00 [received] PHST- 2026/01/26 00:00 [accepted] PHST- 2026/03/07 01:37 [medline] PHST- 2026/02/03 07:41 [pubmed] PHST- 2026/02/03 00:06 [entrez] PHST- 2026/02/02 00:00 [pmc-release] AID - 10.1186/s12884-026-08714-0 [pii] AID - 8714 [pii] AID - 10.1186/s12884-026-08714-0 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Feb 2;26(1):218. doi: 10.1186/s12884-026-08714-0. PMID- 41625660 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260202 LR - 20260926 IS - 2277-9531 (Print) IS - 2319-6440 (Electronic) IS - 2277-9531 (Linking) VI - 14 DP - 2025 TI - Understanding the psychological impact of body weight variations: A study of weight-related body image concerns among young adults. PG - 524 LID - 10.4103/jehp.jehp_120_25 [doi] LID - 524 AB - BACKGROUND: Weight-related body image concerns significantly impact mental health and weight management in young adults (YAs) and are shaped by cultural, societal, and digital factors. Despite the prevalence of these issues, few studies have explored them in this demographic. This study utilizes a validated tool to examine key aspects of weight-related body image concerns in YAs. MATERIALS AND METHODS: A cross-sectional analytical survey was conducted using a pre-validated tool, in the outpatient settings of a tertiary healthcare in India. Snowball and purposive sampling techniques were employed, and data were analyzed using STATA/SE version 14.2. RESULTS: A total of 1071 YAs (mean age: 22.3 +/- 3.5 years) were selected, mostly from middle-income groups (61.9%) and students (63.6%), with a slight female predominance (57.1%). The prevalence of obesity was 25.2%, underweight was 11.5%, and moderate to severe body concerns were present in half of the obese (49.6%) and underweight participants (47.1%), with severe issues highest in obese YAs. Regression analysis showed increased odds of body image issues in the underweight (OR: 1.89 [1.29-2.76], P < 0.001) and obese categories (OR: 2.89 [2.18-3.83], P < 0.001). Subdomain analysis revealed that self-consciousness (P < 0.001) and lack of confidence (P < 0.001) were highest in obese YAs, while anxiety (P < 0.001), loneliness (P < 0.01), and embarrassment (P < 0.001) were highest in the underweight group. CONCLUSION: The study highlights the high prevalence of weight-related body image concerns in YAs, with underweight, overweight, and obese individuals experiencing significant distress. The findings emphasize the need for culturally tailored interventions to improve mental health in YAs with obesity. CI - Copyright: (c) 2025 Journal of Education and Health Promotion. FAU - Anwar, Wareesha AU - Anwar W AD - Department of Home Science, University of Delhi, New Delhi, India. FAU - Ranjan, Piyush AU - Ranjan P AD - Department of Medicine, All India Institute of Medical Sciences, New Delhi, India. FAU - Malhotra, Anita AU - Malhotra A AD - Department of Home Science, Lakshmibai College, University of Delhi, New Delhi, India. FAU - Kandpal, Anshul AU - Kandpal A AD - Department of Medicine, All India Institute of Medical Sciences, New Delhi, India. FAU - Upadhyay, Ashish Datt AU - Upadhyay AD AD - Clinical Research Unit, All India Institute of Medical Sciences, New Delhi, India. FAU - Kaloiya, Gauri Shanker AU - Kaloiya GS AD - Department of Psychiatry and National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, India. FAU - Kumari, Archana AU - Kumari A AD - Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India. FAU - Vikram, Naval Kishore AU - Vikram NK AD - Department of Medicine, All India Institute of Medical Sciences, New Delhi, India. LA - eng PT - Journal Article DEP - 20251229 PL - India TA - J Educ Health Promot JT - Journal of education and health promotion JID - 101593794 PMC - PMC12854327 OTO - NOTNLM OT - Body image OT - body mass index OT - obesity OT - overweight OT - psychometrics OT - young adults OT - youth COIS- The author declares no competing interests. EDAT- 2026/02/02 18:13 MHDA- 2026/02/02 18:14 PMCR- 2025/12/29 CRDT- 2026/02/02 06:55 PHST- 2025/01/20 00:00 [received] PHST- 2025/04/23 00:00 [accepted] PHST- 2026/02/02 18:14 [medline] PHST- 2026/02/02 18:13 [pubmed] PHST- 2026/02/02 06:55 [entrez] PHST- 2025/12/29 00:00 [pmc-release] AID - JEHP-14-524 [pii] AID - 10.4103/jehp.jehp_120_25 [doi] PST - epublish SO - J Educ Health Promot. 2025 Dec 29;14:524. doi: 10.4103/jehp.jehp_120_25. eCollection 2025. PMID- 41625247 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260706 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 16 DP - 2025 TI - Construction and validation of a risk prediction model for metabolic syndrome: a cross-sectional study based on randomized sampling. PG - 1761342 LID - 10.3389/fendo.2025.1761342 [doi] LID - 1761342 AB - OBJECTIVE: The prevalence of metabolic syndrome is high among Chinese residents, and it is crucial to understand the current situation and intervene promptly. In this study, we investigated the current status of metabolic syndrome in some regions of China, analyzed related risk factors, and developed a risk prediction model to guide preventive measures. METHODS: A multistage stratified cluster random sampling method was used to select 3541 permanent residents aged 18-79 years from a district in Beijing for face-to-face questionnaire surveys, physical examinations, and laboratory tests. All participants were randomly divided into training and validation sets. Correlation analysis and multivariate logistic regression were employed to identify risk factors for metabolic syndrome, and a column-line graph prediction model was developed. The discriminative ability and predictive accuracy of the model were assessed by receiver operating characteristic (ROC) curve and calibration curves. RESULTS: The prevalence of metabolic syndrome in this study was 18.4%. The results of multivariate logistic regression analysis showed that increasing age, being male (OR = 1.827), being overweight (OR = 4.865), being obese (OR = 11.482), hazardous alcohol consumption (OR = 1.673), marital/cohabitation history, and specific occupations (agriculture, forestry, fisheries, and water production, and unemployed) were independent risk factors for metabolic syndrome (P < 0.05). The column-line graph prediction model, constructed accordingly, performed well, and the model indicated that BMI and age were the most significant risk factors for metabolic syndrome. The results of model validation showed that the AUCs of the training and validation sets were 0.815 (95% CI: 0.795-0.836) and 0.787 (95% CI: 0.756-0.818), respectively, indicating that the model performed well in discriminating. The model exhibited a good fit on the training set (with 1000 resamples via the Bootstrap method; calibration slope = 1.002, calibration intercept = 0.005; Hosmer-Lemeshow test, P = 0.127 > 0.05). The initial validation set showed signs of slight overfitting, and after probability calibration using the Platt Scaling method, the model's calibration performance was significantly improved (calibration slope = 0.92, calibration intercept = -0.03; Hosmer-Lemeshow test, P = 0.082 > 0.05). The Brier scores of the training set and validation set were 0.120 and 0.136, respectively, with mean absolute errors (MAE) of 0.240 and 0.256, indicating that the model had favorable predictive accuracy and stability. CONCLUSIONS: The metabolic syndrome column-line diagram risk prediction model constructed in this study, based on multivariate logistic regression analysis, has good discriminative ability and high prediction accuracy. The model shows that a large proportion of the current risk factors for metabolic syndrome are modifiable, and that the risk of metabolic syndrome in high-risk groups, such as the elderly, men, people with marital/cohabitation histories, and people with specific occupations, can be reduced through behavioral and lifestyle interventions. This model can provide a scientific basis for the early identification of high-risk groups for metabolic syndrome and has an important guiding value for targeted preventive interventions. CI - Copyright (c) 2026 Zhao, An, Liu, Meng, Liu and Mu. FAU - Zhao, Jiannan AU - Zhao J AD - Shijingshan District Center for Disease Control and Prevention, Beijing, China. FAU - An, Xinhua AU - An X AD - Wulituo Hospital of Shijingshan District, Beijing, China. FAU - Liu, Ling AU - Liu L AD - Shijingshan District Center for Disease Control and Prevention, Beijing, China. FAU - Meng, Jia AU - Meng J AD - Shijingshan District Center for Disease Control and Prevention, Beijing, China. FAU - Liu, Liyong AU - Liu L AD - Shijingshan District Center for Disease Control and Prevention, Beijing, China. FAU - Mu, Yongliang AU - Mu Y AD - Department of Vascular Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260116 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - *Metabolic Syndrome/epidemiology/diagnosis/etiology MH - Male MH - Cross-Sectional Studies MH - Middle Aged MH - Risk Factors MH - China/epidemiology MH - Adult MH - Female MH - Aged MH - Adolescent MH - Young Adult MH - Prediction Algorithms MH - Prevalence MH - Logistic Models MH - Risk Assessment MH - ROC Curve MH - Surveys and Questionnaires PMC - PMC12855082 OTO - NOTNLM OT - age OT - male OT - marry OT - metabolic syndrome OT - obese OT - occupation OT - risk prediction model COIS- The authors declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/02 18:13 MHDA- 2026/02/02 18:14 PMCR- 2026/01/16 CRDT- 2026/02/02 06:51 PHST- 2025/12/05 00:00 [received] PHST- 2025/12/22 00:00 [revised] PHST- 2025/12/25 00:00 [accepted] PHST- 2026/02/02 18:14 [medline] PHST- 2026/02/02 18:13 [pubmed] PHST- 2026/02/02 06:51 [entrez] PHST- 2026/01/16 00:00 [pmc-release] AID - 10.3389/fendo.2025.1761342 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Jan 16;16:1761342. doi: 10.3389/fendo.2025.1761342. eCollection 2025. PMID- 41624492 OWN - NLM STAT- Publisher LR - 20260920 IS - 1748-2798 (Print) IS - 1748-2801 (Electronic) IS - 1748-2798 (Linking) DP - 2026 Jan 4 TI - Development and Validation of the Parental Media Motivations (MEMO) Scales for Child and Parent Media Use in the United States. LID - 10.1080/17482798.2025.2606976 [doi] AB - Parental motivations for their own and their child's media use may shape the quality of media experiences and ultimately child development and family well-being. However, validated scales are lacking. The current paper describes scale development and validation of the Media Motivations for Child (MEMO-C) and Parent (MEMO-P) in 501 parents with young children (2-5 years old). The MEMO-C measures motivations for children's media use, while the MEMO-P measures motivations for parents' own use, emphasizing parents' regulatory and relational goals. Each scale had a three-factor structure (MEMO-C: Regulate, Occupy, Connect; MEMO-P: Regulate, Relax Alone, Connect). These factors demonstrated strong psychometric properties including high reliability, convergent validity, and incremental validity, uniquely predicting child- and parent-related constructs. By measuring parental media motivations through a regulatory and relational lens, these scales enable researchers to more closely examine how family media use is associated with child development and family members' well-being. FAU - Suh, Bolim AU - Suh B AUID- ORCID: 0000-0001-9743-526X AD - University of Wisconsin-Madison, Madison, United States. FAU - Barr, Rachel AU - Barr R AUID- ORCID: 0000-0002-5855-9718 AD - Georgetown University, Washington, United States. FAU - Kerr, Margaret L AU - Kerr ML AUID- ORCID: 0000-0002-1398-4083 AD - University of Wisconsin-Madison, Madison, United States. FAU - Radesky, Jenny AU - Radesky J AUID- ORCID: 0000-0002-7721-7350 AD - University of Michigan, Ann Arbor, USA. FAU - Kirkorian, Heather AU - Kirkorian H AUID- ORCID: 0000-0002-7990-7777 AD - University of Wisconsin-Madison, Madison, United States. LA - eng GR - P01 HD109907/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20260104 PL - England TA - J Child Media JT - Journal of children and media JID - 101318681 PMC - PMC12854708 MID - NIHMS2141034 OTO - NOTNLM OT - family media ecology OT - parental media motivation OT - regulatory media use OT - screen time OT - uses and gratifications COIS- Disclosure statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/02 18:13 MHDA- 2026/02/02 18:13 PMCR- 2026/01/30 CRDT- 2026/02/02 06:46 PHST- 2026/02/02 18:13 [medline] PHST- 2026/02/02 18:13 [pubmed] PHST- 2026/02/02 06:46 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - 10.1080/17482798.2025.2606976 [doi] PST - aheadofprint SO - J Child Media. 2026 Jan 4:10.1080/17482798.2025.2606976. doi: 10.1080/17482798.2025.2606976. PMID- 41624346 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260202 LR - 20260204 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 7 DP - 2025 TI - The effects of traditional games on physical literacy among school-aged children. PG - 1759890 LID - 10.3389/fspor.2025.1759890 [doi] LID - 1759890 AB - INTRODUCTION: Physical literacy is crucial for promoting lifelong engagement in physical activity. In response to rising childhood inactivity, this study explores the impact of traditional children's games on physical literacy within a school context. METHODS: A quasi-experimental design was applied involving 60 students (aged 11-12) from two schools in Trabzon, Turkey. The experimental group participated in an 8-week program of culturally-rooted traditional games. The control group followed standard physical education activities. Pre- and post-test data were collected using a validated Physical Literacy Scale. RESULTS: Statistical analyses indicated significant improvements (p < .001) in all four domains of physical literacy-physical, psychological, social, and cognitive-in the experimental group compared to the control group. DISCUSSION: Traditional games are shown to be inclusive, culturally relevant, and effective pedagogical tools for improving physical literacy in school-aged children. Their integration into school curricula is supported as a cost-effective and holistic educational strategy. CI - (c) 2026 Cinar and Hassani. FAU - Cinar, Meliha AU - Cinar M AD - Department of Physical Education, Istanbul Gedik University, Istanbul, Turkiye. FAU - Hassani, Fahimeh AU - Hassani F AD - Department of Physical Education, Istanbul Gedik University, Istanbul, Turkiye. LA - eng PT - Journal Article DEP - 20260116 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC12855449 OTO - NOTNLM OT - active lifestyles OT - culturally rooted play OT - movement skills OT - physical competence OT - physical literacy OT - traditonal game COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/02 13:09 MHDA- 2026/02/02 13:10 PMCR- 2026/01/16 CRDT- 2026/02/02 06:44 PHST- 2025/12/03 00:00 [received] PHST- 2025/12/17 00:00 [revised] PHST- 2025/12/24 00:00 [accepted] PHST- 2026/02/02 13:10 [medline] PHST- 2026/02/02 13:09 [pubmed] PHST- 2026/02/02 06:44 [entrez] PHST- 2026/01/16 00:00 [pmc-release] AID - 10.3389/fspor.2025.1759890 [doi] PST - epublish SO - Front Sports Act Living. 2026 Jan 16;7:1759890. doi: 10.3389/fspor.2025.1759890. eCollection 2025. PMID- 41621352 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260904 IS - 1878-5506 (Electronic) IS - 1389-9457 (Linking) VI - 140 DP - 2026 Apr TI - Sleep disturbances in children and adolescents with epilepsy: Clinical, polysomnographic and management aspects. PG - 108794 LID - S1389-9457(26)00032-8 [pii] LID - 10.1016/j.sleep.2026.108794 [doi] AB - BACKGROUND: Sleep and epilepsy interact through bidirectional neurobiological mechanisms. In children, sleep disturbances are highly prevalent and may exacerbate seizures while adversely affecting cognition, behaviour, and quality of life. OBJECTIVE: To synthesise current evidence on sleep disturbances in paediatric epilepsy by integrating subjective reports and objective sleep measures across epilepsy severity, syndromes, and common neurodevelopmental comorbidities, and to discuss implications for clinical management. METHODS: Narrative review of studies assessing sleep in children and adolescents with epilepsy using validated questionnaires and objective tools, including polysomnography/video-EEG-polysomnography, actigraphy, and cyclic alternating pattern analysis. Evidence was summarised according to epilepsy severity, epilepsy syndrome, comorbid ADHD/ASD, caregiver outcomes, and management strategies. RESULTS: Questionnaire-based studies consistently report high rates of sleep problems and associations with behavioural difficulties and poorer cognitive performance. Objective evidence, including meta-analytic data, demonstrates reduced total sleep time, decreased sleep efficiency, increased sleep fragmentation, and altered sleep-stage distribution compared with healthy controls. Drug-resistant epilepsy shows a severity gradient characterised by marked macrostructural disruption (reduced N3 and REM sleep, increased wake after sleep onset) and microstructural NREM instability, particularly in children with cognitive impairment. Reported sleep alterations appear syndrome-specific and influenced by seizure burden, nocturnal epileptiform activity, and treatment-related factors. Sleep disruption is also prominent in epilepsy with neurodevelopmental comorbidities and is closely associated with caregiver sleep disturbance and mental health burden. CONCLUSIONS: Sleep impairment in childhood epilepsy is common, clinically meaningful, and potentially modifiable. Systematic screening with validated tools and targeted objective assessment may support interventions that improve sleep quality, seizure-related outcomes, daytime functioning, and family well-being. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - El Halal, Camila Dos Santos AU - El Halal CDS AD - Paediatric Neurologist, Brazil. FAU - Nunes, Magda Lahorgue AU - Nunes ML AD - Pontifical Catholic University of Rio Grande do Sul, Brain Institute (BraIns), Brazil. Electronic address: mlahorguenunes@gmail.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20260119 PL - Netherlands TA - Sleep Med JT - Sleep medicine JID - 100898759 SB - IM MH - Humans MH - *Polysomnography MH - *Epilepsy/complications MH - Child MH - *Sleep Wake Disorders/therapy/diagnosis/physiopathology/complications MH - Adolescent MH - Surveys and Questionnaires MH - Quality of Life MH - Electroencephalography OTO - NOTNLM OT - Adolescents OT - Children OT - Insomnia OT - Polysomnography OT - Sleep disorders COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/02/02 00:29 MHDA- 2026/02/22 05:35 CRDT- 2026/02/01 18:07 PHST- 2025/11/20 00:00 [received] PHST- 2026/01/14 00:00 [revised] PHST- 2026/01/17 00:00 [accepted] PHST- 2026/02/22 05:35 [medline] PHST- 2026/02/02 00:29 [pubmed] PHST- 2026/02/01 18:07 [entrez] AID - S1389-9457(26)00032-8 [pii] AID - 10.1016/j.sleep.2026.108794 [doi] PST - ppublish SO - Sleep Med. 2026 Apr;140:108794. doi: 10.1016/j.sleep.2026.108794. Epub 2026 Jan 19. PMID- 41620790 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Jan 31 TI - The bidirectional dynamic relationship of teacher and peer support: a longitudinal analysis of student engagement in middle school physical education. LID - 10.1186/s40359-026-03960-5 [doi] LID - 285 AB - PURPOSE: This longitudinal study examined the reciprocal relationships among perceived teacher support, peer support, and student engagement in middle school physical education classes. METHODS: Using a two-wave panel design, data were collected from 477 Chinese middle school students at two time points: Wave 1 (Time 1, T1) in November 2022 and Wave 2 (Time 2, T1) in May 2023, with a six-month interval representing a typical academic semester. This temporal spacing allows for observing developmental changes while minimizing seasonal effects on physical activity patterns. Participants completed validated measures of teacher support, peer support, behavioral engagement, and emotional engagement. Data were analyzed via cross-lagged structural equation modeling to test bidirectional pathways while controlling for grade and gender. RESULTS: (1) Behavioral engagement at T1 positively predicted teacher support (beta = 0.22, p < 0.01) and peer support (beta = 0.19, p < 0.01) at T2. (2) Emotional engagement at T1 positively predicted teacher support (beta = 0.22, p < 0.01) and peer support (beta = 0.21, p < 0.01) at T2. (3) Peer support at T1 positively predicted emotional engagement (beta = 0.16, p < 0.01) and teacher support (beta = 0.14, p < 0.05 for behavioral model; beta = 0.17, p < 0.01 for emotional model) at T2. CONCLUSION: These findings reveal a spillover effect wherein student engagement fosters subsequent social support, and peer support reinforces both emotional engagement and teacher support. The study underscores the importance of pedagogical strategies that promote active learning and peer interaction, such as cooperative activities and student-centered tasks, to create mutually reinforcing cycles of engagement and support. CI - (c) 2026. The Author(s). FAU - Zhang, Ting AU - Zhang T AD - Physical Education College, Jiangxi Normal University, Nanchang, 330022, China. FAU - Han, Hongwei AU - Han H AD - School of Physical Education, Shanghai University of Sport, Shanghai, 200438, China. hanhongwei@sus.edu.cn. LA - eng PT - Journal Article DEP - 20260131 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - *Peer Group MH - Longitudinal Studies MH - *School Teachers/psychology MH - *Students/psychology MH - *Social Support MH - Female MH - *Physical Education and Training MH - Male MH - Child MH - Schools MH - Adolescent MH - China PMC - PMC12951929 OTO - NOTNLM OT - Middle school student OT - Peer support OT - Physical education OT - Student engagement OT - Teacher support COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Ethics Committee of College of Physical Education at Jiangxi Normal University. Written informed consent was obtained from all participants. The guidelines outlined in the Declaration of Helsinki were followed. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/01 00:44 MHDA- 2026/03/07 16:12 PMCR- 2026/01/31 CRDT- 2026/01/31 23:37 PHST- 2025/08/19 00:00 [received] PHST- 2026/01/05 00:00 [accepted] PHST- 2026/03/07 16:12 [medline] PHST- 2026/02/01 00:44 [pubmed] PHST- 2026/01/31 23:37 [entrez] PHST- 2026/01/31 00:00 [pmc-release] AID - 10.1186/s40359-026-03960-5 [pii] AID - 3960 [pii] AID - 10.1186/s40359-026-03960-5 [doi] PST - epublish SO - BMC Psychol. 2026 Jan 31;14(1):285. doi: 10.1186/s40359-026-03960-5. PMID- 41620589 OWN - NLM STAT- In-Process LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jan 31 TI - Adherence to the EAT-Lancet planetary health diet and its associations with obesity and health-related quality of life in Iranian adolescents: a cross-sectional study. LID - 10.1186/s12889-025-26174-7 [doi] LID - 746 AB - BACKGROUND: Adolescent obesity and diminished health-related quality of life (HRQoL) remain critical global issues and are further complicated by the urgent need for sustainable diets amid climate change. The Planetary Health Diet Index (PHDI), which is based on EAT-Lancet recommendations, connects human nutrition with environmental sustainability. METHODS: This cross-sectional study of 1,038 students (mean age, 15.13 +/- 1.53 years) from the 2024-2025 academic year assessed dietary intake via a validated 147-item food frequency questionnaire. Anthropometrics followed standard protocols, and HRQoL was evaluated with the Pediatric Quality of Life Inventory Version 4.0 Generic Core Scales (PedsQL). Adjusted binary logistic regression models, controlling for age, sex, ethnicity, socioeconomic status, sleep duration, screen time, and energy intake, were used to analyze associations (SPSS version 28). RESULTS: The mean PHDI score was 50.79 (95% CI, 50.13-51.45; range, 19.66-94.46). According to the adjusted analyses, the highest quartile was associated with lower odds of general obesity (OR, 0.44; 95% CI, 0.24-0.81), abdominal obesity (OR, 0.56; 95% CI, 0.36-0.89), and impaired HRQoL (OR, 0.41; 95% CI, 0.24-0.70; all P < 0.05). CONCLUSION: Greater PHDI adherence is associated with improved anthropometric status and HRQoL in adolescents, underscoring the potential of sustainable diets for holistic health promotion. Longitudinal studies are needed to establish causality and generalizability. CI - (c) 2026. The Author(s). FAU - Derakhshandeh, Soroor AU - Derakhshandeh S AD - Department of Nutritional Sciences, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Namkhah, Zahra AU - Namkhah Z AD - Department of Nutritional Sciences, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Mohebi, Sina AU - Mohebi S AD - Food, Health and Environment (FH&E), MSc Program, University of Eastern Piedmont "Amedeo Avogadro", Vercelli, Italy. FAU - Sobhani, Seyyed Reza AU - Sobhani SR AUID- ORCID: 0000-0002-7308-8504 AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. SeyyedRezaSobhani@gmail.com.com. FAU - Dehnavi, Zahra AU - Dehnavi Z AUID- ORCID: 0000-0003-4926-4229 AD - Department of Nutritional Sciences, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. dehnaviz941@gmail.com. LA - eng GR - 4022488/Mashhad University of Medical Sciences/ PT - Journal Article DEP - 20260131 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM PMC - PMC12933899 OTO - NOTNLM OT - Adolescents OT - Dietary index OT - Health-related quality of life OT - Sustainable diet COIS- Declarations. Ethics approval and consent to participate: The Research Ethics Committee of Mashhad University of Medical Sciences, Mashhad, Iran, approved the study protocol (approval number IR.MUMS.MEDICAL.REC.1403.211). All procedures were performed in accordance with the ethical standards set forth in the 1964 Helsinki Declaration and its subsequent amendments. Parents and legal guardians of adolescents participating in this study were asked for passive informed consent and adolescents themselves were asked for active informed consent before the start of the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/01 00:44 MHDA- 2026/02/01 00:44 PMCR- 2026/01/31 CRDT- 2026/01/31 23:23 PHST- 2025/10/29 00:00 [received] PHST- 2025/12/31 00:00 [accepted] PHST- 2026/02/01 00:44 [pubmed] PHST- 2026/02/01 00:44 [medline] PHST- 2026/01/31 23:23 [entrez] PHST- 2026/01/31 00:00 [pmc-release] AID - 10.1186/s12889-025-26174-7 [pii] AID - 26174 [pii] AID - 10.1186/s12889-025-26174-7 [doi] PST - epublish SO - BMC Public Health. 2026 Jan 31;26(1):746. doi: 10.1186/s12889-025-26174-7. PMID- 41619773 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260706 IS - 2049-4408 (Electronic) IS - 2049-4394 (Linking) VI - 108-B IP - 2 DP - 2026 Feb 1 TI - Psychometric evaluation of Patient-Reported Outcome Measurement Information System (PROMIS) measures in children and adolescents with lower limb orthopaedic conditions : construct validity, reliability, and responsiveness. PG - 259-266 LID - 10.1302/0301-620X.108B2.BJJ-2025-0277.R1 [doi] AB - AIMS: The Patient-Reported Outcomes Measurement Information System (PROMIS) has not been broadly validated for use in paediatric patients with lower limb musculoskeletal conditions. The aim of this study was to evaluate the psychometric properties of PROMIS administered using computerized adaptive testing. METHODS: This was a single-centre prospective study involving consecutive patients, aged between 11 and 17 years, with orthopaedic conditions affecting the lower limbs. The convergent and divergent construct validity of PROMIS domains with corresponding subscales of the Paediatric Outcomes Data Collection Instrument (PODCI) were assessed in Group A. The reliability was assessed by retesting a sub-group (Group B) of patients from Group A with the same PROMIS domains in those whose condition was not expected to vary within a month of their initial assessment. PROMIS domain responses preoperatively, and > six months postoperatively, were assessed in Group C. RESULTS: The construct validity was assessed in 280 patients in Group A, and convergent validity was achieved between the PROMIS and PODCI Mobility domains (r = 0.73; p < 0.001), Upper Extremity domains (r = 0.52; p < 0.001), PROMIS Physical Activity domain and PODCI Sports and Physical Function subscale (r = 0.57; p < 0.001), PROMIS Depressive Symptoms domain and PODCI Happiness subscale (r = -0.54; p < 0.001), and PROMIS Pain domain and PODCI Pain/Comfort subscale (r = -0.71; p < 0.001). Divergent validity criteria were met with a correlation of < 0.30. The median number of questions required to answer on PROMIS was less than on PODCI. Reliability was assessed in 51 patients in Group B, in whom the PROMIS domains were collected again following a mean of 20 days. Test-retest reliability was highest for Mobility (intraclass correlation coefficient (ICC) = 0.84), Depressive Symptoms (ICC = 0.75), and Pain (ICC = 0.74). Responsiveness was assessed in 150 patients in Group C in whom PROMIS domains were collected preoperatively and at a mean of ten months postoperatively. The largest effect sizes were seen in the Pain and Mobility domains, with smaller improvements in the Physical Activity, Depressive Symptoms, and Upper Extremity domains. CONCLUSION: PROMIS domains of Mobility, Physical Activity, Depressive Symptoms, and Pain may be useful for assessing patient-reported health status in paediatric patients with lower limb orthopaedic conditions. CI - (c) 2026 The British Editorial Society of Bone & Joint Surgery. FAU - Nguyen, Hillary Brenda AU - Nguyen HB AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Miller, Patricia E AU - Miller PE AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Sullivan, Nicholas AU - Sullivan N AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Mahan, Susan T AU - Mahan ST AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Spencer, Samantha A AU - Spencer SA AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Kasser, James R AU - Kasser JR AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Milewski, Matthew AU - Milewski M AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Kramer, Dennis AU - Kramer D AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - May, Collin J AU - May CJ AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Boston, Massachusetts, USA. LA - eng PT - Journal Article PT - Validation Study DEP - 20260201 PL - England TA - Bone Joint J JT - The bone & joint journal JID - 101599229 SB - IM MH - Humans MH - Child MH - Adolescent MH - *Patient Reported Outcome Measures MH - Psychometrics MH - Female MH - Male MH - Reproducibility of Results MH - Prospective Studies MH - *Lower Extremity/surgery MH - *Musculoskeletal Diseases/surgery/psychology MH - Surveys and Questionnaires COIS- D. Kramer reports education support payments from Arthrex/Kairos Surgical and Smith & Nephew, unrelated to this study. S. A. Spencer is on the Medical Advisory Board for Little People of America and the Advisory Board of Project FAVA, and is a Board Member of the Massachusetts Orthopaedic Association, Clerk for the Children's Orthopaedic Surgery Foundation, Immediate Past President of the Michigan Medical Alumni Society, and Massachusetts Councilor for the American Academy of Orthopaedic Surgeons. EDAT- 2026/02/01 00:43 MHDA- 2026/02/01 00:44 CRDT- 2026/01/31 19:03 PHST- 2026/02/01 00:44 [medline] PHST- 2026/02/01 00:43 [pubmed] PHST- 2026/01/31 19:03 [entrez] AID - BJJ-2025-0277.R1 [pii] AID - 10.1302/0301-620X.108B2.BJJ-2025-0277.R1 [doi] PST - epublish SO - Bone Joint J. 2026 Feb 1;108-B(2):259-266. doi: 10.1302/0301-620X.108B2.BJJ-2025-0277.R1. PMID- 41615635 OWN - NLM STAT- MEDLINE DCOM- 20260619 LR - 20260813 IS - 2212-1358 (Electronic) IS - 2212-134X (Print) IS - 2212-134X (Linking) VI - 14 IP - 3 DP - 2026 May TI - Artificial intelligence-driven 3D surface-topography app for screening and monitoring adolescent scoliosis: early results from a single institution. PG - 851-858 LID - 10.1007/s43390-026-01282-5 [doi] AB - PURPOSE: Radiation-free tools, such as scoliometers, ultrasound, and Moire topography, have been explored for monitoring Adolescent Idiopathic Scoliosis (AIS), but none have replaced the need for serial spinal radiographs. This study aimed to evaluate the accuracy and criterion validity of a new AI-powered digital health application using 3D surface topography to predict Cobb angles, with the goal of reducing radiation exposure and enabling home-based curve monitoring. METHODS: In a single-center observational study, 125 patients with confirmed or suspected scoliosis underwent smartphone-based 3D surface-topography scans in standing and forward-bending positions. Poor-quality scans (n = 20) were excluded. Radiographic Cobb angles were used as the gold standard. After random allocation, 79 scans formed the training set and 26 formed the validation set; external data (142 controls, 188 scoliosis patients) were added to strengthen training, and 25 controls were added to the test set. Accuracy was expressed as mean absolute error (MAE) and correlation with radiographs. Criterion validity was assessed by sensitivity, specificity, and AUC at clinically meaningful thresholds (10 degrees , 25 degrees , and 40 degrees ). RESULTS: Across 51 test scans (AIS + controls), the algorithm showed a strong correlation with radiographs (r = 0.922, 95% CI 0.866-0.955) and an MAE of 5.9 degrees (95% CI 4.5-7.3). In AIS-only curves of 10-50 degrees , the MAE was 6.4 degrees (95% CI 4.4-8.3). At 10 degrees , sensitivity was 0.962, specificity was 0.960, and AUC was 0.978. At 25 degrees , sensitivity was 0.706, specificity was 0.853, and AUC was 0.917. At 40 degrees , sensitivity was 0.667, specificity was 1.000, and AUC was 1.000. CONCLUSION: This AI-driven 3D surface topography demonstrated high validity for non-radiographic Cobb angle prediction, particularly in mild-to-moderate AIS. It supports safer, more frequent, home-based monitoring, though refinements are needed for severe curves and patients with a higher BMI. CI - (c) 2026. The Author(s). FAU - Parent, Stefan AU - Parent S AUID- ORCID: 0000-0002-4854-2816 AD - Centre de Recherche Azrieli du CHU Sainte-Justine, Montreal, QC, Canada. stefan.parent@umontreal.ca. AD - Division of Orthopaedics, Department of Surgery, CHU Sainte-Justine, Montreal, QC, Canada. stefan.parent@umontreal.ca. AD - Department of Surgery, University of Montreal, Montreal, QC, Canada. stefan.parent@umontreal.ca. FAU - Roy-Beaudry, Marjolaine AU - Roy-Beaudry M AUID- ORCID: 0009-0003-7050-9849 AD - Centre de Recherche Azrieli du CHU Sainte-Justine, Montreal, QC, Canada. FAU - Dufresne, Justin AU - Dufresne J AD - Centre de Recherche Azrieli du CHU Sainte-Justine, Montreal, QC, Canada. FAU - Imbeault, Rachelle AU - Imbeault R AUID- ORCID: 0009-0005-0365-9921 AD - Centre de Recherche Azrieli du CHU Sainte-Justine, Montreal, QC, Canada. FAU - Barchi, Soraya AU - Barchi S AD - Centre de Recherche Azrieli du CHU Sainte-Justine, Montreal, QC, Canada. FAU - Beausejour, Marie AU - Beausejour M AUID- ORCID: 0000-0003-3180-3642 AD - Centre de Recherche Azrieli du CHU Sainte-Justine, Montreal, QC, Canada. AD - Department of Surgery, University of Montreal, Montreal, QC, Canada. AD - Department of Community Health Sciences, Universite de Sherbrooke, Sherbrooke, Canada. LA - eng PT - Journal Article PT - Observational Study DEP - 20260130 PL - England TA - Spine Deform JT - Spine deformity JID - 101603979 SB - IM MH - Humans MH - *Scoliosis/diagnostic imaging/diagnosis MH - Adolescent MH - Female MH - *Artificial Intelligence MH - *Imaging, Three-Dimensional/methods MH - Male MH - Sensitivity and Specificity MH - Reproducibility of Results MH - *Mobile Applications MH - Child MH - Radiography MH - Smartphone PMC - PMC13282326 OTO - NOTNLM OT - 3D surface topography OT - Adolescent idiopathic scoliosis OT - Artificial intelligence OT - Cobb angle OT - Digital health OT - Radiation-free monitoring COIS- Declarations. Conflict of interest: MRB, RI, JD, and SB declare that they have no conflict of interest. MB has received funding PROMPT-IA with Momentum, Mitacs Accelerate International Student Grant. Fonds de Recherche du Quebec en Sante Junior-2 Salary Award (2022-2026). SP has received outside the submitted work: royalties from EOS imaging, he is a co-founder of the company Spinologics Inc., he received consultancy fees from K2M, Medtronic and DePuy Synthes Spine, he received grants from DePuy Synthes Spine, Canadian Institutes of Health Research, Pediatric Orthopaedic Society of North America, Scoliosis Research Society, Medtronic, EOS imaging, Canadian Foundation for Innovation, Setting Scoliosis Straight Foundation, Natural Sciences and Engineering Council of Canada, Fonds de recherche Quebec-Sante, grants, and the Orthopaedic Research and Education Foundation, he received fellowship support from DePuy Synthes and Medtronic, he is the holder of the Academic Chair in Pediatric Spinal Deformities at CHU Ste-Justine, and he is a member of the speaker bureau of Orthopaediatrics. Ethical approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committees and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the ethics committee of the CHU Sainte-Justine. Consent to participate: All research participants or their legal guardians provided written consent to be part of the database and to have the data collected used in ongoing research on scoliosis. Consent for publication: We obtained consent from the responsible authorities to submit this scientific work. EDAT- 2026/01/30 13:18 MHDA- 2026/06/19 12:36 PMCR- 2026/01/30 CRDT- 2026/01/30 11:25 PHST- 2025/09/26 00:00 [received] PHST- 2026/01/10 00:00 [accepted] PHST- 2026/06/19 12:36 [medline] PHST- 2026/01/30 13:18 [pubmed] PHST- 2026/01/30 11:25 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - 10.1007/s43390-026-01282-5 [pii] AID - 1282 [pii] AID - 10.1007/s43390-026-01282-5 [doi] PST - ppublish SO - Spine Deform. 2026 May;14(3):851-858. doi: 10.1007/s43390-026-01282-5. Epub 2026 Jan 30. PMID- 41615545 OWN - NLM STAT- MEDLINE DCOM- 20260318 LR - 20260813 IS - 1573-6695 (Electronic) IS - 1389-4986 (Print) IS - 1389-4986 (Linking) VI - 27 IP - 2 DP - 2026 Feb TI - Validation of the Observational Assessment Tool for Tailoring (OATT). PG - 316-332 LID - 10.1007/s11121-026-01879-2 [doi] AB - Individually tailored interventions can address the myriad multi-level determinants of chronic health conditions. Limited measurement modalities to quantify tailoring disallow examining "active ingredient" effects on outcomes and implementation fidelity. The objective of this study is to develop and validate the Observational Assessment Tool for Tailoring (OATT) for behavioral prevention interventions. We developed the OATT and coded n = 172 videorecorded sessions from two trials of the Family Check-Up(R) 4 Health (FCU4Health), an individually tailored prevention and management program for behavioral health and obesogenic behaviors with English and Spanish-speaking participants. The sample was culturally diverse (> 65% Hispanic/Latino). Confirmatory factor analysis (CFA) tested the two-factor model. McDonald's Omega estimated internal consistency. Discriminant and predictive validity tests were conducted with FCU4Health fidelity, engagement, and health behavior outcomes, informed by the Implementation Cascade Model. CFA confirmed a two-factor structure for both trials (i.e., RMSEA /= 0.95, SRMR < 0.08 chi-square p >/= 0.05). Reliability and inter-rater reliability were good (ICC > 0.77) for both trials and English and Spanish videos. The OATT was not correlated (p > 0.05) with discriminant validity variables. Path analysis for predictive validity indicated that fidelity to the Individualized Treatment Planning factor directly predicts improvements in participant engagement (B = 0.16, p = 0.01, 95% CI [0.03-0.29]), which directly predicts improvements in parent health behaviors 12 months post-baseline (B = 0.18, p = 0.01, 95% CI [0.02-0.34]). The development of the OATT is a critical step to measure and guide tailored intervention development, implementation, and evaluation. Future studies are needed to replicate predictive validity findings and test the OATT factor structure with larger samples and different prevention initiatives. CI - (c) 2026. The Author(s). FAU - Fu, Emily S AU - Fu ES AUID- ORCID: 0000-0002-9070-2975 AD - Departments of Medicine & Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, USA. efu@uchicago.edu. AD - Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. efu@uchicago.edu. FAU - Merle, James L AU - Merle JL AD - Department of Population Health Sciences, Division of Health System Innovation and Research, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT, USA. FAU - Berkel, Cady AU - Berkel C AUID- ORCID: 0000-0001-9664-9485 AD - College of Health Solutions, Arizona State University, Phoenix, AZ, USA. FAU - Brown, C Hendricks AU - Brown CH AD - Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. FAU - Philbin, Sarah AU - Philbin S AD - Health Sciences Integrated PhD Program, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. FAU - Fan, Yiqing AU - Fan Y AD - Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. AD - Department of Psychology, American University, Washington, DC, USA. FAU - McGinnis, Jenna L AU - McGinnis JL AD - Department of Educational Psychology, University of Utah, Salt Lake City, UT, USA. FAU - Demauro, Dania AU - Demauro D AD - College of Health Solutions, Arizona State University, Phoenix, AZ, USA. FAU - DiGregorio, Ariana AU - DiGregorio A AD - College of Health Solutions, Arizona State University, Phoenix, AZ, USA. FAU - Litchey, Janeth AU - Litchey J AD - College of Health Solutions, Arizona State University, Phoenix, AZ, USA. FAU - Smith, Justin D AU - Smith JD AD - Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. AD - Department of Population Health Sciences, Division of Health System Innovation and Research, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT, USA. LA - eng GR - F31HL160534/NHLBI Division of Intramural Research/ GR - F31 HL160534/HL/NHLBI NIH HHS/United States GR - U18DP006255/CC/CDC HHS/United States GR - 2018-68001-27550/U.S. Department of Agriculture/ GR - U18 DP006255/DP/NCCDPHP CDC HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Validation Study DEP - 20260130 PL - United States TA - Prev Sci JT - Prevention science : the official journal of the Society for Prevention Research JID - 100894724 SB - IM MH - Adult MH - Female MH - Humans MH - Male MH - *Health Behavior MH - Middle Aged MH - Randomized Controlled Trials as Topic MH - Health Promotion MH - *Health Impact Assessment/methods PMC - PMC12999605 OTO - NOTNLM OT - Behavior change OT - Implementation fidelity OT - Measurement development OT - Pediatric obesity OT - Tailoring COIS- Declarations. Ethical Approval: This study was designed in accordance with the basic ethical principles of autonomy, beneficence, justice, and non-maleficence and conducted in accordance with the rules of Good Clinical Practice outlined in the most recent Declaration of Helsinki. The study was approved by the Institutional Review Board (IRB) of Northwestern University (STU00215542). The two FCU4Health trials (ethics approval numbers: STUDY00012412; STUDY00009621) and all procedures were reviewed and approved by the Arizona State University IRB. All other participating institutions provided signed reliance agreements ceding to the IRB of Arizona State University. Informed Consent: Consent and assent were obtained from all participants included in the study. Conflict of interest: Cady Berkel and Justin D. Smith co-developed the Family Check-Up 4 Health program. The other authors have no potential conflicts of interest to declare. Clinical Trial Number: This is a secondary analysis using data from the following two clinical trial registration numbers: NCT03013309 ClinicalTrials.gov and NCT04469816 ClinicalTrials.gov. EDAT- 2026/01/30 13:19 MHDA- 2026/03/18 18:36 PMCR- 2026/01/30 CRDT- 2026/01/30 11:21 PHST- 2025/06/20 00:00 [received] PHST- 2026/01/16 00:00 [accepted] PHST- 2026/03/18 18:36 [medline] PHST- 2026/01/30 13:19 [pubmed] PHST- 2026/01/30 11:21 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - 10.1007/s11121-026-01879-2 [pii] AID - 1879 [pii] AID - 10.1007/s11121-026-01879-2 [doi] PST - ppublish SO - Prev Sci. 2026 Feb;27(2):316-332. doi: 10.1007/s11121-026-01879-2. Epub 2026 Jan 30. PMID- 41613926 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260130 LR - 20260201 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - Association between the Infant and Child Feeding Index at 8 months and early childhood neurodevelopment. PG - 1727649 LID - 10.3389/fnut.2025.1727649 [doi] LID - 1727649 AB - OBJECTIVE: To evaluate the association between infant feeding practices, measured by the Infant and Child Feeding Index (ICFI) at 8 months, and early childhood neurodevelopment. METHODS: A total of 705 participants were enrolled from the Shenzhen Birth Cohort Study (SZBC), a prospective longitudinal study. Infant feeding practices at 8 months were assessed via a validated dietary recall method combining 24 h and 7 day recall records. ICFI scores were calculated based on seven components (including breastfeeding and complementary feeding) and dichotomized into qualified (>60% of the total score) versus unqualified groups. Neurodevelopment was evaluated across five domains using the Ages and Stages Questionnaire, Third Edition (ASQ-3) at 8, 12, 18, and 24 months. Multivariable Generalized Estimating Equations (GEE) analyzed the association between ICFI status at 8 months and neurodevelopmental delay across early childhood. RESULTS: At 8 months, 48.5% of infants had qualified ICFI scores. Across the five ASQ-3 domains, the prevalence of developmental delay between 8 and 24 months ranged from 1.0 to 16.8%. After controlling for confounders, infants in the qualified ICFI group exhibited significantly lower odds of delay in the communication domain (OR = 0.51; 95% CI: 0.35-0.75), the problem-solving domain (OR = 0.55; 95% CI: 0.32-0.95), and the personal-social domain (OR = 0.54; 95% CI: 0.37-0.79). CONCLUSION: Higher ICFI scores at 8 months, indicating healthier feeding practices, are associated with reduced risk of neurodevelopmental delays through age two. These findings underscore the importance of promoting targeted feeding guidelines to support early childhood development. CI - Copyright (c) 2026 Li, Zhang, Dai, Liu, Gao, Liu, Wei and Cai. FAU - Li, Xiuxiu AU - Li X AD - Nanshan Maternity & Child Healthcare Hospital of Shenzhen, Shenzhen, China. FAU - Zhang, Jianan AU - Zhang J AD - Tianhe District Center for Disease Control and Prevention of Guangzhou, Guangzhou, China. FAU - Dai, Xiaowei AU - Dai X AD - Nanshan Maternity & Child Healthcare Hospital of Shenzhen, Shenzhen, China. FAU - Liu, Xuemei AU - Liu X AD - Nanshan Maternity & Child Healthcare Hospital of Shenzhen, Shenzhen, China. FAU - Gao, Rui AU - Gao R AD - Shenzhen Cadre and Talent Health Management Center, Shenzhen, China. FAU - Liu, Xuhua AU - Liu X AD - Nanshan Maternity & Child Healthcare Hospital of Shenzhen, Shenzhen, China. FAU - Wei, Min AU - Wei M AD - Nanshan Maternity & Child Healthcare Hospital of Shenzhen, Shenzhen, China. FAU - Cai, Li AU - Cai L AD - Sun Yat-sen University, Guangzhou, China. LA - eng PT - Journal Article DEP - 20260114 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12846993 OTO - NOTNLM OT - Food Frequency Questionnaire OT - ICFI OT - birth cohort OT - feeding practice OT - neurodevelopment COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/30 06:30 MHDA- 2026/01/30 06:31 PMCR- 2026/01/14 CRDT- 2026/01/30 04:47 PHST- 2025/10/18 00:00 [received] PHST- 2025/11/30 00:00 [revised] PHST- 2025/12/24 00:00 [accepted] PHST- 2026/01/30 06:31 [medline] PHST- 2026/01/30 06:30 [pubmed] PHST- 2026/01/30 04:47 [entrez] PHST- 2026/01/14 00:00 [pmc-release] AID - 10.3389/fnut.2025.1727649 [doi] PST - epublish SO - Front Nutr. 2026 Jan 14;12:1727649. doi: 10.3389/fnut.2025.1727649. eCollection 2025. PMID- 41613840 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260130 LR - 20260201 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 16 DP - 2025 TI - Social media use and disordered eating in young adults: the protective and risk pathways of physical activity and body image. PG - 1699756 LID - 10.3389/fpsyg.2025.1699756 [doi] LID - 1699756 AB - BACKGROUND/OBJECTIVES: Social media is a pervasive force in youth culture, shaping body perception and dietary habits. However, the psychological and behavioral pathways linking social media use to eating behavior remain insufficiently understood. This study examined the mediating roles of body image dissatisfaction and physical activity in the association between social media use and dietary behavior among young adults. METHODS: A cross-sectional survey was conducted among 422 Chinese university students (Mean age = 22.82 +/- 2.42) between November 2024 and February 2025. Participants completed validated measures of social media use, body image dissatisfaction (BSQ-16), physical activity (IPAQ-SF), and dietary behavior (DEBQ). Data were analyzed using confirmatory factor analysis (CFA), parallel mediation modeling (PROCESS macro), and ANOVA for subgroup comparisons. RESULTS: Confirmatory factor analysis confirmed the measurement model (CFI = 0.926, RMSEA = 0.057). Social media use significantly predicted higher body image dissatisfaction (beta = 0.578, p < 0.001) and lower physical activity (beta = -348.717, p < 0.001), both of which were associated with disordered eating (beta = 0.442 and beta = -0.000, respectively). Parallel mediation analysis identified two significant indirect effects: through body image dissatisfaction (indirect effect = 0.256, p < 0.001) and physical activity (indirect effect = 0.084, p < 0.001). ANOVA showed that lower physical activity was associated with higher social media use and poorer dietary outcomes. CONCLUSION: Social media is associated with dietary behavior through dual psychological and behavioral pathways. Interventions should target body image resilience and active lifestyles to mitigate the health risks posed by digital media environments. CI - Copyright (c) 2026 Yu, Cui, Liu, Wang, Li and Lipowski. FAU - Yu, Wei AU - Yu W AD - School of Sport Education, Tianjin University of Sport, Tianjin, China. AD - Faculty of Sports and Arts, Harbin Sport University, Harbin, China. FAU - Cui, Liwen AU - Cui L AD - Department of Physical Education, Heilongjiang University of Science and Technology, Harbin, China. FAU - Liu, Changli AU - Liu C AD - School of Sport Education, Tianjin University of Sport, Tianjin, China. FAU - Wang, Jian AU - Wang J AD - College of Physical Education, Qinghai Minzu University, Xining, China. FAU - Li, Jianye AU - Li J AD - Faculty of Physical Education, Gdansk University of Physical Education and Sport, Gdansk, Poland. AD - Department of Physical Education, Shanxi Medical University, Jinzhong, China. FAU - Lipowski, Mariusz AU - Lipowski M AD - Faculty of Social and Humanities, WSB Merito University in Gdansk, Gdansk, Poland. LA - eng PT - Journal Article DEP - 20260114 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC12847240 OTO - NOTNLM OT - body image dissatisfaction OT - dietary behavior OT - parallel mediation model OT - physical activity OT - social media use COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/30 06:30 MHDA- 2026/01/30 06:31 PMCR- 2026/01/14 CRDT- 2026/01/30 04:46 PHST- 2025/09/08 00:00 [received] PHST- 2025/12/09 00:00 [revised] PHST- 2025/12/18 00:00 [accepted] PHST- 2026/01/30 06:31 [medline] PHST- 2026/01/30 06:30 [pubmed] PHST- 2026/01/30 04:46 [entrez] PHST- 2026/01/14 00:00 [pmc-release] AID - 10.3389/fpsyg.2025.1699756 [doi] PST - epublish SO - Front Psychol. 2026 Jan 14;16:1699756. doi: 10.3389/fpsyg.2025.1699756. eCollection 2025. PMID- 41613099 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Negative life events and problematic smartphone use among university students: the mediating role of self-efficacy and the moderating role of physical activity. PG - 1704120 LID - 10.3389/fpubh.2025.1704120 [doi] LID - 1704120 AB - OBJECTIVES: This study explores how negative life events relate to problematic smartphone use among university students and examines whether self-efficacy acts as a mediator and physical activity as a moderator in this relationship. METHODS: A cross-sectional survey was conducted among undergraduates at eight universities in Nanchang, China, from November 2024 to March 2025. Validated instruments were used to assess negative life events (ASLEC), self-efficacy (GSES), physical activity (PARS), and problematic smartphone use (SAS-SV). The sample included 2,680 participants (47.6% male, 52.4% female; mean age = 19.60 years). Statistical analyses included Pearson correlation analysis and PROCESS models for mediation and moderation. RESULTS: Negative life events were positively correlated with problematic smartphone use and negatively correlated with self-efficacy and physical activity. Self-efficacy partially mediated the relationship between negative life events and problematic smartphone use [indirect effect beta = 0.05, 95% CI (0.04, 0.07)], with a significant direct effect. Physical activity attenuated the positive correlation between negative life events and problematic smartphone use (interaction beta = -0.01, p < 0.001). CONCLUSIONS: Negative life events, self-efficacy, physical activity, and problematic smartphone use are interrelated among university students. Enhancing self-efficacy and promoting physical activity may help mitigate problematic smartphone use. However, the cross-sectional design and reliance on self-reports limit causal inference. CI - Copyright (c) 2026 Yang, Huang, Hu, Zhang, Chen, Zhou, Zhu and Xu. FAU - Yang, Chao AU - Yang C AD - Physical Education College, Jiangxi Normal University, Nanchang, China. FAU - Huang, Wenying AU - Huang W AD - Physical Education College, Jiangxi Normal University, Nanchang, China. FAU - Hu, Chang AU - Hu C AD - Physical Education College, Jiangxi Normal University, Nanchang, China. FAU - Zhang, Wen AU - Zhang W AD - Physical Education College, Jiangxi Normal University, Nanchang, China. FAU - Chen, Bin AU - Chen B AD - Physical Education College, Jiangxi Normal University, Nanchang, China. FAU - Zhou, Chi AU - Zhou C AD - Physical Education College, Jiangxi Normal University, Nanchang, China. FAU - Zhu, Dong AU - Zhu D AD - Hunan University of Medicine, Huaihua, Hunan, China. FAU - Xu, Bo AU - Xu B AD - Hunan University of Medicine, Huaihua, Hunan, China. LA - eng PT - Journal Article DEP - 20260114 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Female MH - *Self Efficacy MH - *Students/psychology/statistics & numerical data MH - Cross-Sectional Studies MH - *Exercise/psychology MH - Universities MH - Male MH - *Smartphone/statistics & numerical data MH - Young Adult MH - China/epidemiology MH - *Life Change Events MH - Surveys and Questionnaires MH - Adult MH - Adolescent PMC - PMC12847236 OTO - NOTNLM OT - moderated mediation model OT - negative life events OT - physical activity OT - problematic smartphone use OT - self-efficacy COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/30 06:30 MHDA- 2026/01/30 06:31 PMCR- 2026/01/14 CRDT- 2026/01/30 04:40 PHST- 2025/09/12 00:00 [received] PHST- 2025/12/09 00:00 [revised] PHST- 2025/12/18 00:00 [accepted] PHST- 2026/01/30 06:31 [medline] PHST- 2026/01/30 06:30 [pubmed] PHST- 2026/01/30 04:40 [entrez] PHST- 2026/01/14 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1704120 [doi] PST - epublish SO - Front Public Health. 2026 Jan 14;13:1704120. doi: 10.3389/fpubh.2025.1704120. eCollection 2025. PMID- 41613070 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Perceived risk of type 2 diabetes mellitus: predictors of perceived susceptibility among young adults in Jordan. PG - 1722942 LID - 10.3389/fpubh.2025.1722942 [doi] LID - 1722942 AB - OBJECTIVES: The growing burden of type 2 diabetes mellitus among young adults is a global public health problem. This study aimed to explore risk perception of type 2 diabetes mellitus among university students in Jordan and to identify predictors of perceived susceptibility. METHODS: A cross-sectional study that used proportional stratified sampling to recruit 496 third year university students in all fields of study at the University of Jordan. Participants answered online self-administered validated Arabic questionnaire that was designed based on the constructs of the health belief model. Data was analyzed using Statistical Package for Social Sciences (SPSS) software. RESULTS: The participants in this study evidently underestimated their risk of developing T2DM. Only 25% of students believed that they have high potential of developing T2DM in the future. Perceived susceptibility was low to moderate; it scored lowest among all dimensions of risk perception (mean = 2.86 out of 5). Results of t-test and ANOVA showed that perceived susceptibility was higher among students in engineering and science (p = 0.001), males (p = 0.019), with higher income (p = 0.008), overweight (p = 0.026), and students with little knowledge of T2DM (p = 0.027). Results of logistic regression indicated that high income level was the only significant predictor of higher perceived susceptibility (OR = 2.7. 95%CI 1.35, 3.4). Likelihood of taking preventive action was high (mean = 4.15 out of 5). CONCLUSION: Results of this study highlight the need for health system governance to commit to integrate national efforts to design culturally sensitive interventions to raise awareness about the risk of T2DM in Jordan, especially among young adult population. CI - Copyright (c) 2026 Alkhaldi, Taha, BaniMustafa, Al-Shimi, AlSamhori and Alshyyab. FAU - Alkhaldi, Sireen AU - Alkhaldi S AD - Department of Family and Community Medicine, School of Medicine, University of Jordan, Amman, Jordan. FAU - Taha, Hana AU - Taha H AD - Department of Family and Community Medicine, School of Medicine, University of Jordan, Amman, Jordan. FAU - BaniMustafa, Mishkah AU - BaniMustafa M AD - Department of Family and Community Medicine, School of Medicine, University of Jordan, Amman, Jordan. FAU - Al-Shimi, Rana AU - Al-Shimi R AD - School of Medicine, University of Jordan, Amman, Jordan. FAU - AlSamhori, Jehad AU - AlSamhori J AD - School of Medicine, University of Jordan, Amman, Jordan. FAU - Alshyyab, Muhammad AU - Alshyyab M AD - Department of Public Health and Community Medicine, Jordan University of Science and Technology, Irbid, Jordan. LA - eng PT - Journal Article DEP - 20260114 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Jordan/epidemiology MH - *Diabetes Mellitus, Type 2/psychology/epidemiology MH - Male MH - Female MH - Cross-Sectional Studies MH - Young Adult MH - *Health Knowledge, Attitudes, Practice MH - Surveys and Questionnaires MH - *Students/psychology/statistics & numerical data MH - Risk Factors MH - Universities MH - Adult MH - Disease Susceptibility MH - Perception MH - Adolescent PMC - PMC12847315 OTO - NOTNLM OT - Jordan OT - perceived risk OT - susceptibility OT - type 2 diabetes mellitus OT - young adults COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/30 06:29 MHDA- 2026/01/30 06:30 PMCR- 2026/01/14 CRDT- 2026/01/30 04:39 PHST- 2025/10/11 00:00 [received] PHST- 2025/12/16 00:00 [revised] PHST- 2025/12/31 00:00 [accepted] PHST- 2026/01/30 06:30 [medline] PHST- 2026/01/30 06:29 [pubmed] PHST- 2026/01/30 04:39 [entrez] PHST- 2026/01/14 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1722942 [doi] PST - epublish SO - Front Public Health. 2026 Jan 14;13:1722942. doi: 10.3389/fpubh.2025.1722942. eCollection 2025. PMID- 41613058 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - High sugar-sweetened beverage intake predicts adverse physical, emotional, and sleep health trajectories in adolescents: a 4-year prospective cohort study. PG - 1754072 LID - 10.3389/fpubh.2025.1754072 [doi] LID - 1754072 AB - BACKGROUND: Excessive consumption of sugar-sweetened beverages (SSBs) is a major source of added sugars among adolescents and has been associated with adverse cardiometabolic, emotional, and sleep-related outcomes. However, longitudinal evidence from Asian populations remains limited. This 4-year prospective cohort study examined the associations between SSB intake and multiple health trajectories during adolescence. METHODS: A total of 1,204 adolescents (baseline age: 12.41 +/- 0.89 years; 51.2% girls) from 12 secondary schools in Chongqing, China, were followed annually from 2021 to 2024. SSB intake was assessed using a validated food frequency questionnaire adapted for use among Chinese adolescents. Outcomes included body mass index (BMI), body fat percentage, systolic blood pressure, depressive symptoms (CES-D), academic burnout, and sleep quality (Pittsburgh Sleep Quality Index, PSQI). Longitudinal associations were examined using linear mixed-effects models adjusted for age, sex, socioeconomic status, physical activity, screen time, and baseline BMI. RESULTS: Higher SSB intake was associated with significantly steeper increases in BMI (mean increase: +2.87 vs. +1.90 kg/m(2)), body fat percentage (+4.6% vs. +2.1%), systolic blood pressure (+4.8 vs. +2.1 mmHg), depressive symptoms (CES-D: +6.0 vs. +2.0 points), and sleep disturbance (PSQI: +1.3 vs. +0.4 points) compared with the lowest intake tertile (all p < 0.01). Adolescents in the highest SSB tertile exhibited a 62% greater increase in depressive symptoms over 4 years. Participants who reduced SSB intake by >/=30% showed significantly smaller increases across physical, emotional, and sleep-related outcomes. CONCLUSION: High SSB intake is prospectively associated with unfavorable cardiometabolic, emotional, and sleep-related health trajectories during adolescence. Reducing SSB consumption represents a promising and actionable strategy for school-based health promotion and chronic disease prevention among Asian youth. CI - Copyright (c) 2026 Zhang, Li, Zhang and Zhang. FAU - Zhang, Zeyu AU - Zhang Z AD - School of Educational Science, Xinjiang Normal University, Urumqi, China. FAU - Li, Wanjun AU - Li W AD - Biological Education Teaching and Research Group, Chongqing Tongnan Experimental Middle School, Chongqing, China. FAU - Zhang, Min AU - Zhang M AD - English Education Teaching and Research Group, Suqian Chongwen Junior Middle School, Suqian, China. FAU - Zhang, Yike AU - Zhang Y AD - School of Accounting, Nanjing University of Finance and Economics, Nanjing, Jiangsu, China. LA - eng PT - Journal Article DEP - 20260114 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Female MH - Prospective Studies MH - *Sugar-Sweetened Beverages/adverse effects/statistics & numerical data MH - Adolescent MH - Male MH - China/epidemiology MH - Child MH - Sleep Quality MH - Body Mass Index MH - Sleep MH - Depression/epidemiology MH - Surveys and Questionnaires PMC - PMC12847052 OTO - NOTNLM OT - adolescent health OT - cardiometabolic risk OT - depressive symptoms OT - longitudinal cohort OT - public health OT - sleep quality OT - sugar-sweetened beverages COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/30 06:29 MHDA- 2026/01/30 06:30 PMCR- 2026/01/14 CRDT- 2026/01/30 04:39 PHST- 2025/11/25 00:00 [received] PHST- 2025/12/21 00:00 [revised] PHST- 2025/12/24 00:00 [accepted] PHST- 2026/01/30 06:30 [medline] PHST- 2026/01/30 06:29 [pubmed] PHST- 2026/01/30 04:39 [entrez] PHST- 2026/01/14 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1754072 [doi] PST - epublish SO - Front Public Health. 2026 Jan 14;13:1754072. doi: 10.3389/fpubh.2025.1754072. eCollection 2025. PMID- 41612839 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260130 LR - 20260813 IS - 2287-9129 (Electronic) IS - 2287-9110 (Print) IS - 2287-9110 (Linking) VI - 32 IP - 1 DP - 2026 Jan TI - Parental and child perspectives on healthy lifestyles and artificial intelligence chatbot use among childhood and adolescent cancer survivors: a descriptive comparative study in South Korea. PG - 27-38 LID - 10.4094/chnr.2025.046 [doi] AB - PURPOSE: This study compared healthy lifestyle (HLS) practices and awareness regarding the use of chatbots (A-uC) for health management between childhood and adolescent cancer survivors (CACSs) and their parents, with the aim of assessing the feasibility of tailored artificial intelligence (AI) chatbot-based interventions for holistic survivorship care. METHODS: A descriptive comparative design was employed involving 80 CACSs and 80 parents (N=160) recruited through the Korean Pediatric Cancer Foundation. HLS practices were assessed using a validated seven-domain instrument encompassing physical activity, nutrition, interpersonal relations, stress management, positive life perspective, health responsibility, and spiritual health. A-uC was evaluated using an extended technology acceptance model-based tool. Responses to the open-ended question addressing unmet HLS practices were analyzed using latent Dirichlet allocation topic modeling. RESULTS: No significant differences were observed between CACSs and parents in overall HLS (CACSs: 3.16+/-0.80; parents: 3.18+/-0.36, p=.74). While perceptions across most A-uC domains did not differ significantly, parents demonstrated a significantly higher "intention to use" chatbots for health management than CACSs (p=.03). The mean A-uC scores exceeded 4 (out of 5) in both groups, reflecting positive perceptions of chatbot-based HLS support. Topic modeling identified "exercise," "healthy diet," and "regular lifestyle" as common unmet areas. CONCLUSION: CACSs and their parents share largely concordant views on HLS and A-uC, with a strong interest in chatbot interventions. These findings underscore the potential of tailored AI chatbot programs to address unmet lifestyle needs and promote holistic survivorship care. FAU - Kang, Kyung-Ah AU - Kang KA AD - Professor, College of Nursing, Sahmyook University, Seoul, Korea. FAU - Kim, Shin-Jeong AU - Kim SJ AD - Professor, Research Institute of Nursing Science, School of Nursing, Hallym University, Chuncheon, Korea. FAU - Song, In-Hye AU - Song IH AD - Researcher, College of Nursing, Sahmyook University, Seoul, Korea. FAU - Yoon, Hee-Jin AU - Yoon HJ AD - Undergraduate Student, College of Nursing, Sahmyook University, Seoul, Korea. LA - eng GR - RS-2025-00523681/National Research Foundation of Korea/ PT - Journal Article DEP - 20260130 PL - Korea (South) TA - Child Health Nurs Res JT - Child health nursing research JID - 101603835 PMC - PMC12933495 OTO - NOTNLM OT - Adolescent OT - Artificial intelligence OT - Cancer survivors OT - Childhood OT - Health COIS- Conflict of interest Kyung-Ah Kang and Shin-Jeong Kim serve on the Editorial Board of this Journal; however, they were not involved in the peer-review process or the publication decision for this manuscript. Aside from this, no further potential conflicts of interest exist. EDAT- 2026/01/30 06:29 MHDA- 2026/01/30 06:30 PMCR- 2026/01/01 CRDT- 2026/01/30 02:58 PHST- 2025/10/31 00:00 [received] PHST- 2026/01/07 00:00 [accepted] PHST- 2026/01/30 06:30 [medline] PHST- 2026/01/30 06:29 [pubmed] PHST- 2026/01/30 02:58 [entrez] PHST- 2026/01/01 00:00 [pmc-release] AID - chnr.2025.046 [pii] AID - chnr-2025-046 [pii] AID - 10.4094/chnr.2025.046 [doi] PST - ppublish SO - Child Health Nurs Res. 2026 Jan;32(1):27-38. doi: 10.4094/chnr.2025.046. Epub 2026 Jan 30. PMID- 41612434 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260915 IS - 1741-7015 (Electronic) IS - 1741-7015 (Linking) VI - 24 IP - 1 DP - 2026 Jan 29 TI - Dietary patterns and neuropsychological function in adolescents: a cross-sectional and longitudinal study. LID - 10.1186/s12916-026-04658-6 [doi] LID - 118 AB - BACKGROUND: Adolescence is a critical period for brain development, during which dietary patterns may influence neuropsychological functioning. OBJECTIVE: To examine cross-sectional associations and determine if baseline adherence to the Mediterranean diet (MD) and ultra-processed food (UPF) consumption is associated with changes in adolescent neuropsychological outcomes over 6 months. METHODS: This study represents a secondary analysis of the WALNUTs Smart-Snack Trial. We evaluated 653 adolescents (aged 12-16 years) from Barcelona at baseline and at 6-month follow-up. All dietary data used for these analyses were collected at the baseline timepoint only. MD adherence was measured with the KIDMED index and UPF consumption was assessed using a food frequency questionnaire and classified using the NOVA system. Cognitive domains were assessed at both time points using standardised computer-based tasks: attention (alerting, orienting, executive control) with the Attention Network Test; working memory (4-back) with the N-back task; fluid intelligence with the Primary Mental Abilities-Revised; decision-making with the Roulettes Task; and emotion recognition with the Emotion Recognition Task. Behavioural outcomes were also evaluated at both time points using the self-reported Strengths and Difficulties Questionnaire and teacher-reported Attention-Deficit/Hyperactivity Disorder-DSM-IV scales. Associations were examined using multivariable generalised linear models. To further validate UPF consumption estimations, polyphenol biomarkers were measured in urine in a subsample of 257 participants. RESULTS: Greater adherence to the MD was cross-sectionally linked to fewer behavioural problems and higher scores of executive functioning, while higher UPF consumption was associated with poorer emotion recognition, reduced alerting attention, less advantageous decision-making, more behavioural problems and internalising symptoms. Longitudinally, higher UPF consumption was associated with more internalising symptoms and less advantageous decision-making, whereas MD adherence showed no associations. CONCLUSIONS: Greater MD adherence appears associated with more favourable behavioural and cognitive profiles. In contrast, higher UPF consumption seems to be associated with less favourable profiles across multiple neuropsychological domains in adolescents. However, the limited longitudinal evidence points to complex relationships that warrant further investigation. Overall, these findings highlight the importance of promoting healthier dietary habits during adolescence. CI - (c) 2026. The Author(s). FAU - Manidis, Alexios AU - Manidis A AD - Clinical and Epidemiological Neuroscience (NeuroEpia), Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. alexios.manidis@iispv.cat. AD - Department of Nutrition and Dietetics Sciences, School of Health Sciences, Hellenic Mediterranean University, Sitia, Crete, Greece. alexios.manidis@iispv.cat. AD - ISGlobal, Institut de Salut Global de Barcelona-Campus MAR, PRBB, Barcelona, Spain. alexios.manidis@iispv.cat. FAU - Ayala-Aldana, Nicolas AU - Ayala-Aldana N AD - Clinical and Epidemiological Neuroscience (NeuroEpia), Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. AD - ISGlobal, Institut de Salut Global de Barcelona-Campus MAR, PRBB, Barcelona, Spain. AD - Universitat de Barcelona, Barcelona, Spain. FAU - Bernardo-Castro, Sara AU - Bernardo-Castro S AD - Clinical and Epidemiological Neuroscience (NeuroEpia), Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. AD - ISGlobal, Institut de Salut Global de Barcelona-Campus MAR, PRBB, Barcelona, Spain. FAU - Pinar-Marti, Ariadna AU - Pinar-Marti A AD - Clinical and Epidemiological Neuroscience (NeuroEpia), Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. AD - ISGlobal, Institut de Salut Global de Barcelona-Campus MAR, PRBB, Barcelona, Spain. AD - Universitat Pompeu Fabra, Barcelona, Spain. FAU - Galkina, Polina AU - Galkina P AD - Polyphenol Research Group, Departament de Nutricio, Facultat de Farmacia I Ciencies de L'Alimentacio, Ciencies de L'Alimentacio I Gastronomia, Universitat de Barcelona, Barcelona, Spain. AD - Institut de Nutricio I Seguretat Alimentaria (INSA), Universitat de Barcelona (UB), Santa Coloma de Gramanet, 08921, Spain. AD - CIBER Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Madrid, Spain. FAU - Fernandez-Barres, Silvia AU - Fernandez-Barres S AD - Agencia de Salut Publica de Barcelona (ASPB), Placa Lesseps 1, Barcelona, 08023, Spain. FAU - Ramirez-Carrasco, Patricia AU - Ramirez-Carrasco P AD - Polyphenol Research Group, Departament de Nutricio, Facultat de Farmacia I Ciencies de L'Alimentacio, Ciencies de L'Alimentacio I Gastronomia, Universitat de Barcelona, Barcelona, Spain. AD - Institut de Nutricio I Seguretat Alimentaria (INSA), Universitat de Barcelona (UB), Santa Coloma de Gramanet, 08921, Spain. AD - CIBER Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Madrid, Spain. FAU - Lamuela-Raventos, Rosa M AU - Lamuela-Raventos RM AD - Polyphenol Research Group, Departament de Nutricio, Facultat de Farmacia I Ciencies de L'Alimentacio, Ciencies de L'Alimentacio I Gastronomia, Universitat de Barcelona, Barcelona, Spain. AD - Institut de Nutricio I Seguretat Alimentaria (INSA), Universitat de Barcelona (UB), Santa Coloma de Gramanet, 08921, Spain. AD - CIBER Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Madrid, Spain. FAU - Papandreou, Christopher AU - Papandreou C AD - Clinical and Epidemiological Neuroscience (NeuroEpia), Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. papchris@hmu.gr. AD - Department of Nutrition and Dietetics Sciences, School of Health Sciences, Hellenic Mediterranean University, Sitia, Crete, Greece. papchris@hmu.gr. FAU - Julvez, Jordi AU - Julvez J AD - Clinical and Epidemiological Neuroscience (NeuroEpia), Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. jordi.julvez@iispv.cat. AD - ISGlobal, Institut de Salut Global de Barcelona-Campus MAR, PRBB, Barcelona, Spain. jordi.julvez@iispv.cat. AD - Facultat de Medicina i, Ciencies de La Salut, Human Nutrition Unit , Universitat Rovira I Virgili, Reus, Spain. jordi.julvez@iispv.cat. LA - eng GR - CP14/00108, PI16/00261, PI21/00266/Instituto de Salud Carlos III/ GR - CNS2023-143985/Agencia Estatal de Investigacion/ GR - CNS2023-143985/NextGenerationEU/ PT - Journal Article DEP - 20260129 PL - England TA - BMC Med JT - BMC medicine JID - 101190723 SB - IM MH - Humans MH - Adolescent MH - Cross-Sectional Studies MH - Female MH - Male MH - Child MH - Longitudinal Studies MH - *Diet, Mediterranean MH - *Cognition MH - Neuropsychological Tests MH - Food, Processed MH - Spain MH - *Feeding Behavior PMC - PMC12924547 OTO - NOTNLM OT - Adolescent OT - Cognition OT - Mediterranean diet OT - Neuropsychology OT - Ultra-processed foods COIS- Declarations. Ethics approval and consent to participate: Ethical approval for data collection and analysis for the WSS was granted by the Parc Salut Mar Clinical Research Ethics Committee (approval number: 2015/6026/I). All participants and their legal guardians provided written informed consent at recruitment and follow-up. This investigation is rigorously compliant with the recommendations of the Helsinki Declaration. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/30 06:29 MHDA- 2026/02/21 06:31 PMCR- 2026/01/29 CRDT- 2026/01/30 00:04 PHST- 2025/08/26 00:00 [received] PHST- 2026/01/20 00:00 [accepted] PHST- 2026/02/21 06:31 [medline] PHST- 2026/01/30 06:29 [pubmed] PHST- 2026/01/30 00:04 [entrez] PHST- 2026/01/29 00:00 [pmc-release] AID - 10.1186/s12916-026-04658-6 [pii] AID - 4658 [pii] AID - 10.1186/s12916-026-04658-6 [doi] PST - epublish SO - BMC Med. 2026 Jan 29;24(1):118. doi: 10.1186/s12916-026-04658-6. PMID- 41612115 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260813 IS - 1559-0720 (Electronic) IS - 0163-4984 (Print) IS - 0163-4984 (Linking) VI - 204 IP - 7 DP - 2026 Jul TI - Establishment of Thyroid Volume Reference Curves for Children in Xinjiang: An Exploration of Goiter Diagnosis and the Role of Iodine Nutrition. PG - 4844-4854 LID - 10.1007/s12011-026-05000-0 [doi] AB - The validity of applying universal diagnostic standards across diverse populations is a critical public health concern. This study challenges the suitability of China's national thyroid volume (TTV) criteria by establishing region-specific reference curves for 404 children aged 7-13 years in Xinjiang. Our new sex-specific curves, constructed using GAMLSS models, revealed a goiter prevalence of only 1.5%, a stark contrast to the 9.5% in males and 11.7% in females diagnosed using the national standard (McNemar's test, P < 0.001). This discrepancy underscores a significant overestimation by the current national criteria. Furthermore, our analysis elucidated a nuanced role for iodine: while individual iodine indicators (urinary, salivary, and serum) exhibited significant nonlinear associations with TTV, a composite iodine index showed a protective linear negative correlation (P = 0.012). These findings demonstrate that region-specific standards are imperative for accurate goiter diagnosis. They also suggest that in iodine-sufficient populations, the relationship between iodine and thyroid health is a complex physiological modulation rather than a simple risk paradigm. CI - (c) 2026. The Author(s). FAU - Zhou, Jing AU - Zhou J AD - School of Public Health, Xinjiang Medical University, Urumqi, 830017, China. FAU - Wusiman, Kaisaier AU - Wusiman K AD - Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention, Urumqi, 83002, China. AD - Xinjiang Uygur Autonomous Region Academy of Preventive Medicine, Urumqi, 83002, China. FAU - Abuduwaili, Dannier AU - Abuduwaili D AD - Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention, Urumqi, 83002, China. AD - Xinjiang Uygur Autonomous Region Academy of Preventive Medicine, Urumqi, 83002, China. FAU - Yu, Shuai AU - Yu S AD - Laboratory Department, Bortala Mongolian Autonomous Prefecture Center for Disease Control and Prevention, Bole, 833400, China. FAU - Wang, Chenchen AU - Wang C AD - Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention, Urumqi, 83002, China. 357935099@qq.com. AD - Xinjiang Uygur Autonomous Region Academy of Preventive Medicine, Urumqi, 83002, China. 357935099@qq.com. FAU - Wu, Haiyan AU - Wu H AD - Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention, Urumqi, 83002, China. AD - Xinjiang Uygur Autonomous Region Academy of Preventive Medicine, Urumqi, 83002, China. LA - eng GR - 2025D01E47/Outstanding Youth Science Fund of the Natural Science Foundation of Xinjiang Uygur Autonomous Region/ GR - 2025001CXKYXM650022532/Research Project of Xinjiang Uygur Autonomous Region Health Commission/ GR - 82260648/National Natural Science Foundation of China/ GR - TSYC202301B130/Tianshan Talents Program for Training High-Level Talents in Medicine and Healthcare/ PT - Journal Article DEP - 20260129 PL - United States TA - Biol Trace Elem Res JT - Biological trace element research JID - 7911509 RN - 9679TC07X4 (Iodine) SB - IM MH - Humans MH - *Iodine/urine/administration & dosage/blood MH - *Goiter/diagnosis/epidemiology MH - Child MH - China/epidemiology MH - *Thyroid Gland/pathology MH - Female MH - Male MH - Adolescent MH - Reference Values MH - Nutritional Status MH - Organ Size PMC - PMC13319661 OTO - NOTNLM OT - Children OT - Goiter OT - Iodine nutrition OT - Reference values OT - Thyroid volume OT - Xinjiang COIS- Declarations. Ethics Approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Bortala Mongol Autonomous Prefecture Center for Disease Control and Prevention (Approval No.2025-01). Consent to Participate: Written informed consent was obtained from the parents. Competing interests: The authors declare no competing interests. EDAT- 2026/01/30 00:55 MHDA- 2026/06/30 18:42 PMCR- 2026/01/29 CRDT- 2026/01/29 23:33 PHST- 2025/10/24 00:00 [received] PHST- 2026/01/15 00:00 [accepted] PHST- 2026/06/30 18:42 [medline] PHST- 2026/01/30 00:55 [pubmed] PHST- 2026/01/29 23:33 [entrez] PHST- 2026/01/29 00:00 [pmc-release] AID - 10.1007/s12011-026-05000-0 [pii] AID - 5000 [pii] AID - 10.1007/s12011-026-05000-0 [doi] PST - ppublish SO - Biol Trace Elem Res. 2026 Jul;204(7):4844-4854. doi: 10.1007/s12011-026-05000-0. Epub 2026 Jan 29. PMID- 41611454 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 1 DP - 2026 Jan 29 TI - Strengthening active outdoor living among children residing in two disadvantaged neighbourhoods in Copenhagen, Denmark: a mixed methods study protocol for the Happy Healthy Active Children initiative. PG - e107453 LID - 10.1136/bmjopen-2025-107453 [doi] LID - e107453 AB - INTRODUCTION: The Happy Healthy Active Children (HHAC) initiative is a multicomponent community-based initiative aimed at promoting physical activity, food literacy and nature literacy among children in early childhood kindergarten and primary school settings. Developed in collaboration between Activity Experts and Community Stakeholders, HHAC integrates thematic activities (Play, Nature, Food) across kindergartens, schools and the broader community. The initiative responds to growing concerns about declining physical activity levels, insufficient contact with nature and poor dietary habits in childhood, factors known to influence long-term health and well-being. This protocol outlines the design, implementation and planned evaluation of the HHAC initiative. METHODS AND ANALYSIS: HHAC is carried out within the long-term strategic initiative Tingbjerg Changing Diabetes. Following the Supersetting approach, HHAC addresses inequity in health by mobilising resources across local settings (kindergartens, schools and the local community arenas) and population groups (children, parents, staff and other community members) to develop and implement contextually relevant activities promoting outdoor play, cooking and nature experiences. Activities are evaluated using a within-subject design in kindergartens, while in schools a quasi-experimental design with matched control groups is applied. Data is collected at baseline and follow-up through accelerometry, validated questionnaires and structured observations. Primary outcomes include physical activity levels, food literacy and nature literacy. Analyses apply linear mixed-effects models to account for repeated measures and clustering at the institutional level. The evaluation also investigates implementation processes and context-mechanism configurations through a comprehensive realist evaluation. This includes developing a programme theory, conducting interviews with children, parents, staff and other local stakeholders and participant observations aiming to explore experiences and the mechanisms through which the activities contribute to changes in behaviour and well-being. All data will be analysed and condensed for a model for transferability. ETHICS AND DISSEMINATION: Findings will be disseminated through peer-reviewed journals, conference presentations and public engagement activities targeting educators, policymakers and health professionals. The intervention materials will also be made freely available to support broader implementation. The study procedures were registered and approved by The Capital Region's centre for data reviews 'Videnscenter for Dataanmeldelser' (Reference: P-2023-14277). All procedures were carried out under relevant regulations and guidelines. Written information about the study was given to all school principals, teachers and parents/guardians before the start of the study, and written informed consent is obtained from all legal guardians of all participants in their native language prior to child enrolment. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Stougaard, Maria AU - Stougaard M AUID- ORCID: 0000-0002-5573-4971 AD - Steno Diabetes Center Copenhagen, Department of Prevention Health Promotion and Community Care, Herlev, Capital Region of Denmark, Denmark. FAU - Termansen, Tina AU - Termansen T AD - Steno Diabetes Center Copenhagen, Department of Prevention Health Promotion and Community Care, Herlev, Capital Region of Denmark, Denmark tina.termansen@regionh.dk. FAU - Stjernqvist, Nanna Wurr AU - Stjernqvist NW AUID- ORCID: 0009-0002-3854-3329 AD - Steno Diabetes Center Copenhagen, Department of Prevention Health Promotion and Community Care, Herlev, Capital Region of Denmark, Denmark. FAU - Borring, Andrea Skov AU - Borring AS AD - Steno Diabetes Center Copenhagen, Department of Prevention Health Promotion and Community Care, Herlev, Capital Region of Denmark, Denmark. FAU - Villersholt, Niklas Lynge AU - Villersholt NL AD - Steno Diabetes Center Copenhagen, Department of Prevention Health Promotion and Community Care, Herlev, Capital Region of Denmark, Denmark. FAU - Friis, Nadia AU - Friis N AD - Steno Diabetes Center Copenhagen, Department of Prevention Health Promotion and Community Care, Herlev, Capital Region of Denmark, Denmark. FAU - Mullertz, Alberte Laura Oest AU - Mullertz ALO AD - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Capital Region of Denmark, Denmark. FAU - Elsborg, Peter AU - Elsborg P AD - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Capital Region of Denmark, Denmark. FAU - Mejsner, Sofie Buch AU - Mejsner SB AD - Steno Diabetes Center Copenhagen, Department of Prevention Health Promotion and Community Care, Herlev, Capital Region of Denmark, Denmark. FAU - Bloch, Paul AU - Bloch P AD - Steno Diabetes Center Copenhagen, Department of Prevention Health Promotion and Community Care, Herlev, Capital Region of Denmark, Denmark. LA - eng PT - Journal Article DEP - 20260129 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Exercise MH - *Health Promotion/methods MH - Denmark MH - Child MH - Research Design MH - Child, Preschool MH - Schools MH - Neighborhood Characteristics MH - Vulnerable Populations MH - Play and Playthings MH - Male MH - Program Evaluation PMC - PMC12887510 OTO - NOTNLM OT - Capacity Building OT - Community-Based Participatory Research OT - Family OT - Health Education OT - Health Equity OT - PUBLIC HEALTH COIS- Competing interests: None declared. EDAT- 2026/01/30 00:54 MHDA- 2026/01/30 00:55 PMCR- 2026/01/29 CRDT- 2026/01/29 21:02 PHST- 2026/01/30 00:55 [medline] PHST- 2026/01/30 00:54 [pubmed] PHST- 2026/01/29 21:02 [entrez] PHST- 2026/01/29 00:00 [pmc-release] AID - bmjopen-2025-107453 [pii] AID - 10.1136/bmjopen-2025-107453 [doi] PST - epublish SO - BMJ Open. 2026 Jan 29;16(1):e107453. doi: 10.1136/bmjopen-2025-107453. PMID- 41610488 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 87 DP - 2026 Mar-Apr TI - Healthy lifestyle program based on a mobile serious game-extended version for childhood cancer survivors: Development and evaluation of user satisfaction. PG - 286-296 LID - S0882-5963(26)00035-7 [pii] LID - 10.1016/j.pedn.2026.01.024 [doi] AB - PURPOSE: This study aimed to develop a Healthy Lifestyle Program Based on a Mobile Serious Game-Extended version (HLP-MSGe) for childhood cancer survivors (CCSs) and evaluate the satisfaction level of a HLP-MSGe. METHODS: The HLP-MSGe for CCSs included 33 quests with 7 minigames in 7 healthy lifestyle subfactors (health responsibility, physical activity, nutrition, positive life perspective, interpersonal relationships, stress management, and spiritual health). Five experts validated the content, organization, and usability of the HLP-MSGe. A satisfaction survey consisting of 5-point Likert scales was answered by CCSs in South Korea aged 6-14 years old whose cancer treatment was terminated at least 12 months previously. Data were analyzed using means and standard deviations. RESULTS: "Healthy village-Acorn island" was named to an HLP-MSGe-based initial game called "Healthy village-Hope Island". The content validity index score by experts ranged from 0.93 to 1.00, with a mean of 0.95. The mean score of satisfaction with the HLP-MSGe was 4.16 (SD = 0.68) out of 5. CONCLUSION: HLP-MSGe, a mobile serious game, is a health education modality that meets the learning needs of CCSs who recognize games as educational media and is an appropriate educational medium to increase the efficiency and continuity of self-directed health care. IMPLICATIONS FOR PRACTICE: HLP-MSGe for CCSs intervention can contribute to a new paradigmatic approach to healthcare that maximizes the effectiveness of ongoing health self-management of CCSs. It can also be used as a platform to provide health education based on the human holism model, reflecting the multifaceted needs of CCSs including spirituality. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Kang, Kyung-Ah AU - Kang KA AD - College of Nursing, Sahmyook University, Seoul, Republic of Korea. FAU - Song, In-Hye AU - Song IH AD - College of Nursing, Sahmyook University, Seoul, Republic of Korea. Electronic address: songih407@naver.com. FAU - Kim, Han-Ho AU - Kim HH AD - College of Future Convergence, Sahmyook University, Seoul, Republic of Korea. LA - eng PT - Journal Article DEP - 20260128 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM MH - Humans MH - Child MH - Female MH - Adolescent MH - *Healthy Lifestyle MH - Male MH - *Video Games MH - Republic of Korea MH - *Cancer Survivors/psychology MH - *Health Promotion/methods MH - *Patient Satisfaction MH - Program Evaluation MH - *Neoplasms/therapy MH - Surveys and Questionnaires OTO - NOTNLM OT - Cancer survivors OT - Child OT - Health education OT - Lifestyle health promotion COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/01/30 00:54 MHDA- 2026/03/26 01:03 CRDT- 2026/01/29 18:04 PHST- 2025/03/27 00:00 [received] PHST- 2026/01/14 00:00 [revised] PHST- 2026/01/15 00:00 [accepted] PHST- 2026/03/26 01:03 [medline] PHST- 2026/01/30 00:54 [pubmed] PHST- 2026/01/29 18:04 [entrez] AID - S0882-5963(26)00035-7 [pii] AID - 10.1016/j.pedn.2026.01.024 [doi] PST - ppublish SO - J Pediatr Nurs. 2026 Mar-Apr;87:286-296. doi: 10.1016/j.pedn.2026.01.024. Epub 2026 Jan 28. PMID- 41609190 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 1557-8992 (Electronic) IS - 1044-5463 (Linking) VI - 36 IP - 3 DP - 2026 Apr TI - Sex-Specific Effects of Relative Fat Mass on Attention-Deficit/Hyperactivity Disorder: Insights from the 1999-2004 National Health and Nutrition Examination Survey. PG - 136-143 LID - 10.1177/10445463261416680 [doi] AB - BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in childhood. Conventional adiposity indicators have been linked to ADHD. Relative fat mass (RFM), a novel adiposity measure, has demonstrated advantages in predicting metabolic and cardiovascular disease risk, conditions that share overlapping pathophysiological mechanisms with ADHD. This study aimed to investigate the association between RFM and ADHD, with a particular focus on sex-specific differences. METHODS: Data were obtained from the 1999-2004 National Health and Nutrition Examination Survey, including 5089 children aged 6-14 years. RFM was calculated using height and waist circumference, and ADHD was defined based on physician diagnosis reported in the questionnaire. Multivariable logistic regression models were applied to assess the association between RFM and ADHD. Smooth curve fitting was conducted to validate the results, and subgroup analyses were performed separately for boys and girls. RESULTS: A significant sex-specific association between RFM and ADHD was observed. Among boys, higher RFM levels were inversely associated with ADHD (Model 3: odds ratio [OR] = 0.967, 95% confidence interval [CI]: 0.946-0.989), whereas among girls, higher RFM levels were positively associated with ADHD (Model 3: OR = 1.043, 95% CI: 1.007-1.081). Smooth curve fitting confirmed these opposite linear trends in both sexes. Subgroup analyses further demonstrated that this sex-specific pattern was consistent across strata defined by age, health insurance status, maternal smoking during pregnancy, and birth weight. CONCLUSIONS: There is a significant sex-specific association between RFM and ADHD, showing an inverse relationship in boys and a positive association in girls. These findings suggest that the influence of adiposity distribution on ADHD differs by sex, highlighting the importance of considering sex differences when evaluating risk factors for ADHD. FAU - Bi, Sitong AU - Bi S AD - Department of Children, Beijing Luhe Hospital, Capital Medical University, Beijing, China. FAU - Li, Huijing AU - Li H AD - Department of Children, Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Beijing, China. FAU - Xu, Xinyang AU - Xu X AD - Department of Children, Beijing Luhe Hospital, Capital Medical University, Beijing, China. FAU - Li, Lihua AU - Li L AD - Department of Children, Beijing Luhe Hospital, Capital Medical University, Beijing, China. LA - eng PT - Journal Article DEP - 20260129 PL - United States TA - J Child Adolesc Psychopharmacol JT - Journal of child and adolescent psychopharmacology JID - 9105358 SB - IM MH - Humans MH - *Attention Deficit Disorder with Hyperactivity/epidemiology/physiopathology MH - Male MH - Female MH - Child MH - Nutrition Surveys MH - Adolescent MH - *Adiposity/physiology MH - Sex Factors MH - Risk Factors MH - Logistic Models MH - Waist Circumference MH - United States/epidemiology OTO - NOTNLM OT - ADHD OT - NHANES OT - children OT - relative fat mass OT - sex-specific EDAT- 2026/01/29 14:02 MHDA- 2026/04/22 06:34 CRDT- 2026/01/29 07:44 PHST- 2026/04/22 06:34 [medline] PHST- 2026/01/29 14:02 [pubmed] PHST- 2026/01/29 07:44 [entrez] AID - 10.1177/10445463261416680 [doi] PST - ppublish SO - J Child Adolesc Psychopharmacol. 2026 Apr;36(3):136-143. doi: 10.1177/10445463261416680. Epub 2026 Jan 29. PMID- 41608104 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260129 LR - 20260131 IS - 1948-9358 (Print) IS - 1948-9358 (Electronic) IS - 1948-9358 (Linking) VI - 17 IP - 1 DP - 2026 Jan 15 TI - Role of fasting glucose and glycated hemoglobin for gestational diabetes mellitus diagnosis: A prospective study. PG - 112882 LID - 10.4239/wjd.v17.i1.112882 [doi] LID - 112882 AB - BACKGROUND: Fasting glucose and glycated hemoglobin (HbA1c) were used to diagnose gestational diabetes during the coronavirus disease 2019 (COVID-19) pandemic. AIM: To determine whether the diagnostic criteria used during the COVID-19 pandemic may play a role outside the pandemic. METHODS: From May 2022 to July 2024, 354 females with an altered 50-g oral glucose tolerance test (OGTT), the usual diagnostic test (100-g OGTT), and the alternative diagnostic (A) criteria (fasting glucose >/= 95 mg/dL and/or HbA1c >/= 5.7%) were tested simultaneously, resulting in four different groups: OGTT+/A+ (n = 20); OGTT+/A- (n = 60); OGTT-/A+ (n = 24); and OGTT-/A- (n = 250). Groups were compared for clinical characteristics and obstetric and perinatal outcomes. RESULTS: Sensitivity of the alternative criteria was 25% and specificity was 91.2%. Body mass index (BMI) was similar from the OGTT-/A+ and OGTT+/A+ groups (30.1 +/- 6.3 kg/m(2) and 32.7 +/- 5.3 kg/m(2), respectively) and significantly higher from the OGTT+/A- and OGTT-/A- groups (26.8 +/- 5.1 kg/m(2) and 25.6 +/- 5.0 kg/m(2), respectively). The between-group differences were similar for the respective rates of large for gestational age (LGA) infants (OGTT+/A+: 38.9%, OGTT+/A-: 11.8%, OGTT-/A+: 29.4%, OGTT-/A-: 12.4%; P = 0.028). In the regression analysis a history of macrosomia [odds ratio (OR) = 7.948, 95% confidence interval (95%CI): 2.269-27.842; P = 0.001] and higher pregestational BMI (OR = 1.069, 95%CI: 1.002-1.140; P = 0.042) independently increased the risk of LGA. CONCLUSION: Despite insufficient validity to replace the OGTT, alternative criteria identify a group of patients with a higher risk profile and adverse perinatal outcomes who could benefit for health interventions. CI - (c)The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. FAU - Molina-Vega, Maria AU - Molina-Vega M AD - Unidad de Gestion Clinica Endocrinologia y Nutricion, Hospital Universitario Virgen de la Victoria, Malaga 29010, Spain. AD - Instituto de Investigacion Biomedica de Malaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Malaga 29590, Spain. AD - Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y la Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid 28029, Spain. molinavegamaria@gmail.com. FAU - Estebanez-Prieto, Maria J AU - Estebanez-Prieto MJ AD - Unidad de Gestion Clinica Endocrinologia y Nutricion, Hospital Universitario Virgen de la Victoria, Malaga 29010, Spain. FAU - Fernandez-Valero, Andrea AU - Fernandez-Valero A AD - Unidad de Gestion Clinica Endocrinologia y Nutricion, Hospital Universitario Virgen de la Victoria, Malaga 29010, Spain. FAU - Lima-Rubio, Fuensanta AU - Lima-Rubio F AD - Instituto de Investigacion Biomedica de Malaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Malaga 29590, Spain. FAU - Fernandez-Ramos, Ana M AU - Fernandez-Ramos AM AD - Unidad de Gestion Clinica de Laboratorio, Hospital Universitario Virgen de la Victoria, Malaga 29010, Spain. FAU - Linares-Pineda, Teresa M AU - Linares-Pineda TM AD - Instituto de Investigacion Biomedica de Malaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Malaga 29590, Spain. FAU - Morcillo, Sonsoles AU - Morcillo S AD - Unidad de Gestion Clinica Endocrinologia y Nutricion, Hospital Universitario Virgen de la Victoria, Malaga 29010, Spain. AD - Instituto de Investigacion Biomedica de Malaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Malaga 29590, Spain. AD - Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y la Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid 28029, Spain. FAU - Picon-Cesar, Maria J AU - Picon-Cesar MJ AD - Unidad de Gestion Clinica Endocrinologia y Nutricion, Hospital Universitario Virgen de la Victoria, Malaga 29010, Spain. AD - Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y la Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid 28029, Spain. LA - eng PT - Journal Article PL - United States TA - World J Diabetes JT - World journal of diabetes JID - 101547524 PMC - PMC12835985 OTO - NOTNLM OT - Diagnostic criteria OT - Fasting blood glucose OT - Gestational diabetes OT - Glycated hemoglobin OT - Large for gestational age COIS- Conflict-of-interest statement: The authors declare that they have no conflicts of interest. EDAT- 2026/01/29 07:34 MHDA- 2026/01/29 07:35 PMCR- 2026/01/15 CRDT- 2026/01/29 04:51 PHST- 2025/08/08 00:00 [received] PHST- 2025/09/04 00:00 [revised] PHST- 2025/11/21 00:00 [accepted] PHST- 2026/01/29 07:35 [medline] PHST- 2026/01/29 07:34 [pubmed] PHST- 2026/01/29 04:51 [entrez] PHST- 2026/01/15 00:00 [pmc-release] AID - 10.4239/wjd.v17.i1.112882 [doi] PST - ppublish SO - World J Diabetes. 2026 Jan 15;17(1):112882. doi: 10.4239/wjd.v17.i1.112882. PMID- 41606993 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260813 IS - 1600-0412 (Electronic) IS - 0001-6349 (Print) IS - 0001-6349 (Linking) VI - 105 IP - 3 DP - 2026 Mar TI - Differences in prediction of adverse perinatal outcome in term pregnancies by choice of fetal growth reference: A validation study. PG - 466-478 LID - 10.1111/aogs.70136 [doi] AB - INTRODUCTION: Our objectives were to evaluate the association between fetal growth abnormalities and adverse perinatal outcomes in term pregnancies using four different fetal growth references: the recently published Swedish references by Lindstrom et al., the currently used Swedish references by Marsal et al., and the international standards by the WHO and INTERGROWTH-21st (IG21st). The study aimed to evaluate the performance of each reference and determine which reference most accurately identifies small for gestational age (SGA) infants at risk of perinatal mortality and morbidity. MATERIAL AND METHODS: This population-based cohort study included 1 126 059 singleton term births in Sweden from 2010 to 2020. Data were obtained from national registers, including the Swedish Medical Birth Register and the Swedish Neonatal Quality Register. Birthweight centiles were calculated using each growth reference. Adverse perinatal outcomes were categorized by severity and included stillbirth, neonatal death, and serious neonatal morbidity. Logistic regression models were used to assess predictive performance, and sensitivity and false positive rates (FPR) were calculated for SGA thresholds (<3rd and <10th centiles). RESULTS: The distribution of birthweight centiles varied significantly across references. For SGA <3rd centile, the rate ranged from 9.6% for Lindstrom, 2.5% for Marsal, 1.9% for WHO, to 0.7% for IG21st. All references showed similar overall predictive performance (C-index approximately 0.67) but with different discriminatory ability. The predicted risk of perinatal death increased at lower centiles for the Lindstrom reference than for the Marsal and WHO references, and at higher centiles for the IG21st reference. The Lindstrom reference identified the highest proportion of infants as SGA and had the highest sensitivity but also the highest FPR for detecting adverse outcomes. The IG21st reference classified the smallest proportion as SGA, resulting in the lowest sensitivity and FPR. CONCLUSIONS: While all fetal growth references showed comparable predictive ability for adverse perinatal outcomes, they differed substantially in sensitivity and FPR. When the top priority is to identify as many at-risk fetuses as possible, Lindstrom et al.'s reference seems to be the best choice. However, when the top priority is a balanced sensitivity versus FPR, the WHO reference seems most suitable for clinical practice in this population of term births. CI - (c) 2026 The Author(s). Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG). FAU - Lindstrom, Linda AU - Lindstrom L AUID- ORCID: 0000-0003-4427-1075 AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. FAU - Ahlsson, Fredrik AU - Ahlsson F AUID- ORCID: 0000-0002-8413-9274 AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. FAU - Axelsson, Ove AU - Axelsson O AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. AD - Centre for Clinical Research Sormland, Uppsala University, Eskilstuna, Sweden. FAU - Granfors, Michaela AU - Granfors M AUID- ORCID: 0000-0002-2925-3779 AD - Division of Clinical Epidemiology, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden. AD - Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Gothenburg, Sweden. FAU - Lampa, Erik AU - Lampa E AD - Department of Medical Sciences, Uppsala University, Uppsala, Sweden. FAU - Nelander, Maria AU - Nelander M AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. FAU - Wikstrom, Anna-Karin AU - Wikstrom AK AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. LA - eng GR - LUL-964880/Region Uppsala/ GR - Fodelsefonden/ PT - Journal Article PT - Validation Study DEP - 20260128 PL - United States TA - Acta Obstet Gynecol Scand JT - Acta obstetricia et gynecologica Scandinavica JID - 0370343 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Sweden/epidemiology MH - *Infant, Small for Gestational Age MH - Infant, Newborn MH - *Fetal Development MH - *Pregnancy Outcome MH - Birth Weight MH - *Fetal Growth Retardation/diagnosis MH - Reference Values MH - Adult MH - Predictive Value of Tests MH - Perinatal Mortality MH - Cohort Studies PMC - PMC12942058 OTO - NOTNLM OT - fetal growth retardation OT - growth charts OT - perinatal care OT - perinatal death OT - perinatal mortality OT - pregnancy high-risk OT - pregnancy outcome OT - pregnancy trimester third COIS- None of the authors have a conflict of interest to declare. EDAT- 2026/01/29 07:34 MHDA- 2026/03/06 09:11 PMCR- 2026/01/28 CRDT- 2026/01/29 01:42 PHST- 2025/12/20 00:00 [revised] PHST- 2025/09/17 00:00 [received] PHST- 2025/12/31 00:00 [accepted] PHST- 2026/03/06 09:11 [medline] PHST- 2026/01/29 07:34 [pubmed] PHST- 2026/01/29 01:42 [entrez] PHST- 2026/01/28 00:00 [pmc-release] AID - AOGS70136 [pii] AID - 10.1111/aogs.70136 [doi] PST - ppublish SO - Acta Obstet Gynecol Scand. 2026 Mar;105(3):466-478. doi: 10.1111/aogs.70136. Epub 2026 Jan 28. PMID- 41606948 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260901 IS - 1532-5040 (Electronic) IS - 0959-3985 (Linking) VI - 42 IP - 9 DP - 2026 Sep TI - Operationalizing wellness in physiotherapy: development and validation of a 0-100 wellness physical therapy index from a national population survey. PG - 1171-1180 LID - 10.1080/09593985.2026.2621961 [doi] AB - BACKGROUND: Physiotherapists are increasingly expected to promote physical activity and reduce sedentary time, but there is no simple, field-specific metric that summarizes these behaviors for everyday practice. OBJECTIVE: To develop a 0-100 Wellness Physical Therapy Index (WPTI) combining domain-specific physical activity and sedentary time, and to examine its validity and potential clinical utility in a national sample of adults. METHODS: A cross-sectional secondary analysis of the Sasakawa Sports Foundation "Sports Life Survey 2024 (Adults)" was conducted. Leisure and transport physical activity (min/week) and sedentary time (min/day; reverse-coded) were winsorized and transformed into standardized scores. Principal component analysis generated data-driven weights used to construct the Wellness Physical Therapy Index (WPTI) and rescale it from 0 to 100. Analytic survey weights were constructed using raking with trimming. Distributional properties, internal consistency, convergent validity with total metabolic equivalent (MET) minutes/week, and criterion validity for achieving the World Health Organization (WHO) guideline (>/=600 MET-minutes/week) were evaluated using weighted regression, receiver operating characteristic analyses, and restricted cubic splines. RESULTS: Among 2966 adults with complete data, the mean weighted WPTI score was 20.9 (standard deviation (SD) 11.3). The index showed acceptable internal consistency and moderate correlations with total MET-minutes/week. Higher WPTI scores were strongly associated with meeting the World Health Organization guideline (odds ratio per 10-point increase 19.9, 95% confidence interval 15.7-25.2). Discrimination was excellent (area under the curve 0.865) with good calibration and robust results across sensitivity analyses. CONCLUSIONS: The WPTI provides a practice-ready, physiotherapy-specific index that integrates domain-specific activity and sedentary time into a single 0-100 score. It may support rapid screening, communication about movement and sitting, and the translation of population surveillance data into routine physiotherapy practice. FAU - Kise, Shinyu AU - Kise S AD - Department of Tourism and Health Studies (Sponsored by Ryukyuseimeisaiseikai), Institute for Tourism and Health, Naha, Japan. LA - eng PT - Journal Article PT - Validation Study DEP - 20260128 PL - England TA - Physiother Theory Pract JT - Physiotherapy theory and practice JID - 9015520 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Adult MH - Male MH - Middle Aged MH - *Sedentary Behavior MH - *Physical Therapy Modalities MH - *Exercise MH - Reproducibility of Results MH - *Health Promotion MH - Young Adult MH - Aged MH - Adolescent OTO - NOTNLM OT - Physiotherapy OT - health promotion OT - measurement validation OT - screening OT - sedentary behavior OT - survey weighting EDAT- 2026/01/29 07:34 MHDA- 2026/09/01 05:41 CRDT- 2026/01/29 01:02 PHST- 2026/09/01 05:41 [medline] PHST- 2026/01/29 07:34 [pubmed] PHST- 2026/01/29 01:02 [entrez] AID - 10.1080/09593985.2026.2621961 [doi] PST - ppublish SO - Physiother Theory Pract. 2026 Sep;42(9):1171-1180. doi: 10.1080/09593985.2026.2621961. Epub 2026 Jan 28. PMID- 41605452 OWN - NLM STAT- MEDLINE DCOM- 20260723 LR - 20260723 IS - 1938-2480 (Electronic) IS - 1538-8506 (Linking) VI - 39 IP - 10 DP - 2026 Aug TI - Magnetic Resonance Imaging as a Stand-Alone Tool Fails to Accurately Assess Medial Patellofemoral Ligament Integrity: A Radiographic Analysis. PG - 516-520 LID - 10.1055/a-2796-8709 [doi] AB - The medial patellofemoral ligament (MPFL) is of critical importance for patellar stability and is universally incompetent in patients with patella dislocations. However, radiological (magnetic resonance imaging [MRI]) assessment of the MPFLs' integrity following dislocation is variable, adding confusion to patients and providers during treatment decision-making. We aimed to assess the reliability of MRI to evaluate MPFL integrity by measuring inter- and intraobserver agreement between a musculoskeletal radiologist and an orthopaedic surgeon, specializing in sports medicine using a novel standardized MRI-based scoring system. We anticipated higher intraobserver than interobserver reliability of MPFL integrity. We retrospectively reviewed 100 consecutive knee MRIs: 50 from patients with a clinical history of recent acute patellofemoral dislocation and 50 controls drawn from an anterior cruciate ligament (ACL) injury cohort who had no history or clinical symptoms of patellar instability. Two blinded reviewers, an orthopaedic surgeon with fellowship training in sports medicine and subspecialty expertise in patellofemoral pathology, and a fellowship-trained musculoskeletal radiologist, independently evaluated the MPFL on axial MRIs. Demographic characteristics (age, body mass index, sex) did not differ significantly between the instability and control groups. Eight percent of patellar instability patients had their MPFL graded as "intact" in our first review. Twenty-six percent of ACL control patients had their MPFL graded as at least attenuated. Intraobserver reliability was substantial to excellent and interobserver reliability was fair to moderate. Our findings demonstrate that MRI-based evaluation of MPFL integrity lacks the consistency and accuracy required for confident clinical decision-making and that MRI findings do not universally correlate with clinical history. These findings support a growing consensus that current imaging analyses alone are insufficient for surgical decision-making in patellofemoral instability, particularly in the assessment of the MPFL.Level III. CI - Thieme. All rights reserved. FAU - Volaski, Harrison A AU - Volaski HA AD - Department of Orthopaedic Surgery, Montefiore Einstein, Bronx, New York, United States. FAU - Stich, Joshua L AU - Stich JL AD - Department of Orthopaedic Surgery, Albert Einstein College of Medicine, Bronx, New York, United States. FAU - Krell, Ethan S AU - Krell ES AD - Department of Orthopaedic Surgery, Montefiore Einstein, Bronx, New York, United States. FAU - Berman, Daniel C AU - Berman DC AD - Department of Orthopaedic Surgery, Montefiore Einstein, Bronx, New York, United States. FAU - Lo, Yungtai AU - Lo Y AD - Department of Orthopaedic Surgery, Albert Einstein College of Medicine, Bronx, New York, United States. FAU - Thompson, Lee AU - Thompson L AD - Department of Radiology, Montefiore Einstein, Bronx, New York, United States. FAU - Drummond, Mauricio AU - Drummond M AD - Department of Orthopaedic Surgery, Montefiore Einstein, Bronx, New York, United States. FAU - Hossack, Micheal D AU - Hossack MD AD - Department of Orthopaedic Surgery, Montefiore Einstein, Bronx, New York, United States. FAU - Levy, Benjamin J AU - Levy BJ AUID- ORCID: 0000-0002-0430-7494 AD - Department of Orthopaedic Surgery, Montefiore Einstein, Bronx, New York, United States. LA - eng PT - Journal Article DEP - 20260128 PL - Germany TA - J Knee Surg JT - The journal of knee surgery JID - 101137599 SB - IM MH - Humans MH - *Magnetic Resonance Imaging MH - Female MH - Retrospective Studies MH - *Patellar Dislocation/diagnostic imaging MH - *Joint Instability/diagnostic imaging MH - Reproducibility of Results MH - *Patellofemoral Joint/diagnostic imaging/pathology MH - Male MH - Adult MH - Observer Variation MH - Young Adult MH - *Patellar Ligament/diagnostic imaging/pathology MH - Adolescent COIS- B.J.L. has received educational support from Gotham Surgical Solutions & Devices Inc. and Prodigy Surgical Distributions Inc. D.C.B. has received hospitality payments from Synthes GmbH. E.S.K. has received hospitality payments from Arthrex Inc. M.D. has received hospitality payments from Arthrex Inc. and Smith and Nephew Inc. and educational support from Gotham Surgical Solutions & Devices Inc. EDAT- 2026/01/29 01:47 MHDA- 2026/07/24 00:38 CRDT- 2026/01/28 19:24 PHST- 2026/07/24 00:38 [medline] PHST- 2026/01/29 01:47 [pubmed] PHST- 2026/01/28 19:24 [entrez] AID - 10.1055/a-2796-8709 [doi] PST - ppublish SO - J Knee Surg. 2026 Aug;39(10):516-520. doi: 10.1055/a-2796-8709. Epub 2026 Jan 28. PMID- 41605302 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 1090-2139 (Electronic) IS - 0889-1591 (Linking) VI - 134 DP - 2026 May TI - Lymphocyte-based inflammatory biomarkers during the postpartum period and postpartum depression symptoms in U.S. women. PG - 106466 LID - S0889-1591(26)00214-X [pii] LID - 10.1016/j.bbi.2026.106466 [doi] AB - BACKGROUND: Postpartum depression (PPD) has multiple cascading negative effects on maternal and infant health. Inflammation is a potential factor for the development of PPD. However, lymphocyte-based inflammatory biomarkers, including platelet-to-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR) and monocyte-lymphocyte ratio (MLR), and PPD remains understudied, especially in U.S. women. METHODS: We conducted a cross-sectional study based on the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2020 pre-pandemic data. Based on demographics and reproductive questionnaires, two strategies were employed to include eligible postpartum women. PPD symptoms were assessed using the PHQ-9 questionnaire. Weighted logistic regression models, restricted cubic spline (RCS) models, eXtreme Gradient Boosting (XGBoost) machine learning (ML) model, subgroup analysis and sensitivity analyses were performed to analyze the relationships between these biomarkers and PPD symptoms. RESULTS: A total of 1,361 postpartum women within the 3-year postpartum period based on strategy 1, and 762 women ranges from one to twenty-eight months postpartum based on strategy 2 were included in analyses. After adjusted for all covariates, PLR during the postpartum period was significantly associated with the reduced risk of PPD symptoms based on both strategies (OR = 0.49, 95% CI: 0.26-0.94, P = 0.033; OR = 0.30, 95% CI: 0.15-0.60, P < 0.001). There was a non-linear relationship between PLR and the risk of PPD symptoms (P-non-linear = 0.011, P-non-linear = 0.001). ML revealed PLR as one important variable for PPD symptoms. Interestingly, postpartum time modified the association between PLR and PPD symptoms (P for interaction = 0.026). The association was significant in women within 12 months postpartum (OR = 0.23, 95% CI: 0.11-0.49, P < 0.001) but not in women with beyond 12 months postpartum. Sensitivity analyses validated the robustness of our findings. CONCLUSIONS: PLR during the postpartum period is an independent risk factor for PPD symptoms in U.S. women, exhibiting its potential as a novel marker for PPD symptoms. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Xie, Kaipeng AU - Xie K AD - Department of Public Health, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, China. Electronic address: kaipengxie@njmu.edu.cn. LA - eng PT - Journal Article DEP - 20260126 PL - Netherlands TA - Brain Behav Immun JT - Brain, behavior, and immunity JID - 8800478 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - *Depression, Postpartum/blood/immunology/diagnosis MH - Biomarkers/blood MH - Cross-Sectional Studies MH - *Postpartum Period/blood MH - United States MH - *Lymphocytes MH - Inflammation/blood MH - Adult MH - Nutrition Surveys MH - Neutrophils OTO - NOTNLM OT - MLR OT - NHANES OT - NLR OT - PLR OT - Postpartum depression OT - Postpartum period COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/01/29 01:49 MHDA- 2026/04/12 04:37 CRDT- 2026/01/28 19:11 PHST- 2025/07/01 00:00 [received] PHST- 2025/12/22 00:00 [revised] PHST- 2026/01/25 00:00 [accepted] PHST- 2026/04/12 04:37 [medline] PHST- 2026/01/29 01:49 [pubmed] PHST- 2026/01/28 19:11 [entrez] AID - S0889-1591(26)00214-X [pii] AID - 10.1016/j.bbi.2026.106466 [doi] PST - ppublish SO - Brain Behav Immun. 2026 May;134:106466. doi: 10.1016/j.bbi.2026.106466. Epub 2026 Jan 26. PMID- 41602872 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260128 LR - 20260131 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 13 DP - 2025 TI - Reliability of the PREFIT fitness-test battery in Chilean preschoolers. PG - 1654731 LID - 10.3389/fped.2025.1654731 [doi] LID - 1654731 AB - INTRODUCTION: This study explores the test-retest reliability of the FITness in PREschoolers (PREFIT) battery, including cardiorespiratory fitness [20 m shuttle run test (SRT)], upper-body muscle strength (handgrip strength), lower-body explosive strength (standing long jump), speed (4 x 10 m shuttle run), and static balance (one-leg stance), in Chilean preschoolers considering weight status, sex, and age. METHODS: The study included 171 Chilean preschoolers (5.4 +/- 0.7 years). The PREFIT battery was applied using a test-retest design within 7-10 days between evaluations, and weight status was determined using BMI z-scores (ClinicalTrials.gov: NCT04269135). Statistical analyses included test-retest differences, Lin's concordance correlation coefficient, Cohen's effect size (d), standard error of measurement, intraclass correlation coefficient (ICC), and Bland-Altman plots. Analyses were performed using STATA. RESULTS: Among the 171 preschoolers (5.4 +/- 0.7 years), test-retest reliability ranged from excellent to moderate for handgrip strength (ICC = 0.8502; 95% CI: 0.81-0.90), 4 x 10 m shuttle run test (ICC = 0.7696, 95% CI: 0.71-0.84), and PREFIT 20 m SRT (ICC = 0.6656; 95% CI: 0.58-0.74), but was poor for the one-leg stance test (ICC = 0.46; 95% CI: 0.36-0.63). SEM and MDC95 values indicated that changes of 0.85 kg, MDC = 9,502.35 kg (handgrip strength), >/=0.89 s (4 x 10 m shuttle run test), >/=5.33 laps (20 m shuttle run test), and >/=12.43 cm (standing long jump) exceeded measurement error. Reliability was similar across sex, age, and weight-status groups. Bland-Altman analyses showed proportional bias and heteroscedasticity for the 20 m shuttle run test and one-leg stance. At the same time, the remaining tests demonstrated consistent measurement error throughout the performance spectrum. CONCLUSION: The PREFIT battery is appropriate for field application among Chilean preschool children, except for the one-leg stance test, which demonstrated inadequate reliability and proportional bias. Reporting MDC95 enables the interpretation of significant change within educational and intervention contexts. CI - (c) 2026 Soto-Sanchez, Leyton-Dinamarca, Kain, Fernandez-Valero, Castro-Cisterna, Arias-Tellez and Ortega. FAU - Soto-Sanchez, Johana AU - Soto-Sanchez J AD - Biomedicine Center, Laboratory of Physical Activity, Exercise and Health, Faculty of Medicine and Health Sciences, Universidad Mayor, Santiago, Chile. FAU - Leyton-Dinamarca, Barbara AU - Leyton-Dinamarca B AD - Public Nutrition Unit, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile. FAU - Kain, Juliana AU - Kain J AD - Public Nutrition Unit, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile. FAU - Fernandez-Valero, Paz AU - Fernandez-Valero P AD - Carrera de Entrenador en Actividad Fisica y Deporte, Facultad de Ciencias Humanas, Universidad Bernardo O'Higgins, Santiago, Chile. FAU - Castro-Cisterna, Silvia AU - Castro-Cisterna S AD - Department of Physical Education, Faculty of Education, University of the Americas, Santiago, Chile. FAU - Arias-Tellez, Maria Jose AU - Arias-Tellez MJ AD - Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile. FAU - Ortega, Francisco B AU - Ortega FB AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, and CIBEROBN Physiopathology of Obesity and Nutrition, Granada, Spain. AD - Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland. LA - eng SI - ClinicalTrials.gov/NCT04269135 PT - Journal Article DEP - 20260112 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC12833291 OTO - NOTNLM OT - cardiorespiratory fitness OT - childhood obesity OT - children OT - fitness OT - girls-boys OT - muscular fitness OT - physical fitness OT - preschool COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/28 07:48 MHDA- 2026/01/28 07:49 PMCR- 2026/01/12 CRDT- 2026/01/28 05:04 PHST- 2025/06/26 00:00 [received] PHST- 2025/12/10 00:00 [revised] PHST- 2025/12/11 00:00 [accepted] PHST- 2026/01/28 07:49 [medline] PHST- 2026/01/28 07:48 [pubmed] PHST- 2026/01/28 05:04 [entrez] PHST- 2026/01/12 00:00 [pmc-release] AID - 10.3389/fped.2025.1654731 [doi] PST - epublish SO - Front Pediatr. 2026 Jan 12;13:1654731. doi: 10.3389/fped.2025.1654731. eCollection 2025. PMID- 41602002 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Allergy-compatible symptoms among federated swimmers in Portugal: a cross-sectional study using the AQUA(R) questionnaire. PG - 1731628 LID - 10.3389/fpubh.2025.1731628 [doi] LID - 1731628 AB - Swimmers are chronically exposed to water disinfection by-products (commonly from chlorination) and to indoor air conditions that may aggravate allergic and respiratory symptoms. Evidence is robust for elite cohorts, but competitive swimmers outside Olympic settings remain understudied. We conducted a cross-sectional, anonymous online survey among Portuguese competitive swimmers, officially registered with the national federation, aged 16 years or older (April-May 2025). The validated Allergy Questionnaire for Athletes (AQUA((R)); 21 items; positive >/=5 points) screened for allergy-compatible symptoms. Associations with demographics, training exposure, and pool environment were examined using descriptive statistics and bivariate tests (alpha = 0.05); exploratory logistic regression assessed independent predictors. Of 100 respondents, 95 valid questionnaires were analyzed. The prevalence of AQUA-positive screening was 81.1% (n = 77/95). Upper-airway complaints were most frequent (e.g., nasal obstruction 63.2%; rhinorrhea 61.1%), followed by cough 55.8% and ocular pruritus (51.6%). AQUA positivity was higher in women vs. men (88.7% vs. 71.4%, p = 0.036). Younger age (16-25 years) and >/=7 weekly training sessions were also associated with higher positivity (p = 0.011 and p = 0.012, respectively). A temperature gradient was evident (/=7 sessions/week, and pool water temperature >25 degrees C remained independent predictors. Allergy-compatible symptoms were common among competitive swimmers, with environmental and training-related correlations. Findings support routine symptom screening (AQUA) in clubs alongside attention to pool management (temperature, ventilation). Larger studies with clinical confirmation and objective environmental monitoring are warranted. CI - Copyright (c) 2026 Ramos, Neiva and Lourenco. FAU - Ramos, Miguel AU - Ramos M AD - Faculty of Health Sciences, University of Beira Interior, Covilha, Portugal. FAU - Neiva, Henrique P AU - Neiva HP AD - Department of Sport Sciences, University of Beira Interior, Covilha, Portugal. AD - Research Centre in Sport Sciences, Health Sciences and Human Development (CIDESD), Covilha, Portugal. FAU - Lourenco, Olga AU - Lourenco O AD - Faculty of Health Sciences, University of Beira Interior, Covilha, Portugal. AD - Department of Medical Sciences, Faculty of Health Sciences, RISE-Health, University of Beira Interior, Covilha, Portugal. LA - eng PT - Journal Article DEP - 20260112 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - 0 (Disinfectants) SB - IM MH - Humans MH - Portugal/epidemiology MH - Cross-Sectional Studies MH - Female MH - Male MH - Adolescent MH - *Swimming/statistics & numerical data MH - Surveys and Questionnaires MH - Adult MH - *Hypersensitivity/epidemiology MH - Young Adult MH - *Athletes/statistics & numerical data MH - Prevalence MH - Swimming Pools MH - *Disinfectants/adverse effects PMC - PMC12832999 OTO - NOTNLM OT - AQUA questionnaire OT - allergic symptoms OT - asthma OT - athletes OT - chloramines OT - cross-sectional study OT - indoor air quality OT - swimming COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author HN declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/01/28 07:47 MHDA- 2026/01/28 19:21 PMCR- 2026/01/12 CRDT- 2026/01/28 04:56 PHST- 2025/12/18 00:00 [received] PHST- 2025/11/21 00:00 [revised] PHST- 2025/12/25 00:00 [accepted] PHST- 2026/01/28 19:21 [medline] PHST- 2026/01/28 07:47 [pubmed] PHST- 2026/01/28 04:56 [entrez] PHST- 2026/01/12 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1731628 [doi] PST - epublish SO - Front Public Health. 2026 Jan 12;13:1731628. doi: 10.3389/fpubh.2025.1731628. eCollection 2025. PMID- 41601261 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260714 IS - 2153-2176 (Electronic) IS - 2153-2168 (Linking) VI - 22 IP - 2 DP - 2026 Mar TI - Psychosocial Outcomes Reported in Randomized Behavioral Intervention Trials for Children and Adolescents with Overweight and Obesity: A Scoping Review. PG - 110-136 LID - 10.1177/21532176251408689 [doi] AB - BACKGROUND: Many children and adolescents with overweight or obesity experience negative psychosocial health consequences. Systematic reviews show that behavioral interventions can help improve specific psychosocial outcomes. This scoping review aims to identify and map the different types of psychosocial outcomes measured and reported in randomized behavioral intervention trials for managing pediatric overweight and obesity. METHODS: A total of 11 databases were searched until February 2024. We included randomized behavioral intervention trials for children and adolescents ( 0.90). Multivariate analysis confirmed PTS as an independent predictor of ACL rupture: each additional 1 degrees increase in MPTS was associated with a 14% higher odds of ACL injury (odds ratio [OR] 1.14, 95% confidence interval [CI]: 1.08-1.21, p < 0.001). Age, sex and body mass index were not significantly associated with ACL rupture. CONCLUSIONS: High MPTS is an independent anatomical risk factor for ACL rupture in children. Systematic measurement of PTS on radiographs or MRI should be considered during the evaluation of paediatric ACL injuries. Surgeons should be aware that children with a steep PTS may require more individualized surgical planning and follow-up. LEVEL OF EVIDENCE: Level III. CI - (c) 2026 European Society of Sports Traumatology, Knee Surgery and Arthroscopy. FAU - Piercecchi, Antoine AU - Piercecchi A AUID- ORCID: 0009-0008-7844-0117 AD - Department of Orthopedic Surgery, Institute for Locomotion, Aix-Marseille University, Marseille, France. AD - Department of Biomechanics, Institute for Locomotion, APHM, CNRS, ISM, St Marguerite Hospital, Aix-Marseille University, Marseille, France. FAU - Chaal, Lyes AU - Chaal L AD - Department of Orthopedic Surgery, Institute for Locomotion, Aix-Marseille University, Marseille, France. AD - Department of Biomechanics, Institute for Locomotion, APHM, CNRS, ISM, St Marguerite Hospital, Aix-Marseille University, Marseille, France. FAU - Druel, Julien AU - Druel J AD - Department of Orthopedic Surgery, Institute for Locomotion, Aix-Marseille University, Marseille, France. AD - Department of Biomechanics, Institute for Locomotion, APHM, CNRS, ISM, St Marguerite Hospital, Aix-Marseille University, Marseille, France. FAU - Patel, Romir AU - Patel R AD - Department of Biomechanics, Institute for Locomotion, APHM, CNRS, ISM, St Marguerite Hospital, Aix-Marseille University, Marseille, France. FAU - Peufly, Clemence AU - Peufly C AD - Department of Orthopedic Surgery, Institute for Locomotion, Aix-Marseille University, Marseille, France. AD - Department of Biomechanics, Institute for Locomotion, APHM, CNRS, ISM, St Marguerite Hospital, Aix-Marseille University, Marseille, France. FAU - Chouffani, Elie AU - Chouffani E AD - Department of Orthopedic Surgery, Institute for Locomotion, Aix-Marseille University, Marseille, France. AD - Department of Biomechanics, Institute for Locomotion, APHM, CNRS, ISM, St Marguerite Hospital, Aix-Marseille University, Marseille, France. FAU - Pesenti, Sebastien AU - Pesenti S AD - Department of Orthopedic Surgery, Institute for Locomotion, Aix-Marseille University, Marseille, France. AD - Department of Biomechanics, Institute for Locomotion, APHM, CNRS, ISM, St Marguerite Hospital, Aix-Marseille University, Marseille, France. FAU - Ollivier, Matthieu AU - Ollivier M AD - Department of Orthopedic Surgery, Institute for Locomotion, Aix-Marseille University, Marseille, France. AD - Department of Biomechanics, Institute for Locomotion, APHM, CNRS, ISM, St Marguerite Hospital, Aix-Marseille University, Marseille, France. LA - eng PT - Journal Article DEP - 20260126 PL - Germany TA - Knee Surg Sports Traumatol Arthrosc JT - Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA JID - 9314730 SB - IM OTO - NOTNLM OT - anterior cruciate ligament OT - meniscus OT - paediatric OT - posterior tibial slope OT - risk factor OT - skeletally immature EDAT- 2026/01/26 06:27 MHDA- 2026/01/26 06:27 CRDT- 2026/01/26 03:43 PHST- 2025/12/12 00:00 [revised] PHST- 2025/09/28 00:00 [received] PHST- 2025/12/23 00:00 [accepted] PHST- 2026/01/26 06:27 [medline] PHST- 2026/01/26 06:27 [pubmed] PHST- 2026/01/26 03:43 [entrez] AID - 10.1002/ksa.70277 [doi] PST - aheadofprint SO - Knee Surg Sports Traumatol Arthrosc. 2026 Jan 26. doi: 10.1002/ksa.70277. PMID- 41582372 OWN - NLM STAT- Publisher LR - 20260126 IS - 1873-4294 (Electronic) IS - 1568-0266 (Linking) DP - 2026 Jan 15 TI - A Review on Gamma-Oryzanol as a Multitarget Therapeutic Agent for Metabolic Syndrome: Mechanisms, Preclinical Evidence, and Clinical Prospects. LID - 10.2174/0115680266379551251128092015 [doi] AB - Metabolic syndrome (MetS) is a multifactorial disorder characterized by central obesity, insulin resistance, dyslipidemia, and hypertension, which collectively increase the risk of type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), and non-alcoholic fatty liver disease (NAFLD). Due to the growing global burden of MetS, there is increasing interest in nutraceuticals such as gamma-oryzanol (gamma-ORY), a bioactive compound derived from rice bran oil (RBO), as potential therapeutic agents. A systematic literature search was conducted through July 2024 using PubMed, Google Scholar, and SciFinder. The keyword "gamma-oryzanol" was combined with terms related to MetS and its components. Original preclinical and clinical studies were included, while reviews and book chapters were excluded; however, their references were screened for additional relevant studies. Preclinical studies indicate that gamma-ORY targets multiple molecular pathways, including activation of AMP-activated protein kinase, upregulation of peroxisome proliferatoractivated receptor-alpha, inhibition of nuclear factor-kappaB, and promotion of glucose transporter type 4 translocation. These mechanisms collectively improve glucose and lipid metabolism, enhance insulin sensitivity, and reduce inflammation. Clinical trials, primarily involving adults with T2DM, obesity, dyslipidemia, or postmenopausal women (aged 30-70 years, mixed ethnicities), report that gamma-ORY reduces total cholesterol (10-15%), LDL-C (8-12%), triglycerides (10-18%), fasting glucose (10-25 mg/dL), and HbA1c (0.3-0.8%). Compared to conventional therapies such as statins (LDL-C reduction: 30-50%) or antihypertensives (e.g., irbesartan), gamma-ORY demonstrates milder efficacy but better tolerability, and may enhance the antihypertensive effects of irbesartan. Notably, clinical studies consistently report a favorable safety profile for gamma-ORY, with minimal adverse effects and no major safety concerns to date. Overall, gamma-ORY shows promise as a safe, multitarget nutraceutical for MetS management, with antioxidant, anti-inflammatory, and lipid-lowering properties. However, the generalizability of current findings is limited by small sample sizes, inconsistent dosing regimens, and underrepresentation of diverse populations (e.g., various ethnic groups and pediatric cohorts). Large-scale, well-designed clinical trials are needed to validate its efficacy, optimize dosing, and assess long-term safety compared to standard therapies. CI - Copyright(c) Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. FAU - Dutta, Partha Pratim AU - Dutta PP AD - Faculty of Pharmaceutical Science, Assam Down Town University, Panikhaiti, Guwahati, Assam, 781026, India. FAU - Saikia, Lunasmrita AU - Saikia L AD - Faculty of Pharmaceutical Science, Assam Down Town University, Panikhaiti, Guwahati, Assam, 781026, India. FAU - Law, Douglas AU - Law D AD - Faculty of Health and Life Sciences, Inti International University, 71800, Nilai, Negeri Sembilan, Malaysia. FAU - Kuppusamy, Sandhanam AU - Kuppusamy S AD - Department of Pharmacology, KMCH College of Pharmacy, Coimbatore-641048, Tamil Nadu, India. FAU - Kalita, Pratap AU - Kalita P AD - Pratiksha Institute of Pharmaceutical Sciences, Guwahati-781026, Assam, India. LA - eng PT - Journal Article DEP - 20260115 PL - United Arab Emirates TA - Curr Top Med Chem JT - Current topics in medicinal chemistry JID - 101119673 SB - IM OTO - NOTNLM OT - AMPK. OT - Adiponectin OT - Dyslipidemia OT - Gamma-oryzanol OT - Hypertension OT - Insulin resistance OT - Metabolic syndrome OT - Nutraceuticals OT - PPAR-alpha OT - Rice bran oil EDAT- 2026/01/26 06:27 MHDA- 2026/01/26 06:27 CRDT- 2026/01/26 00:13 PHST- 2025/01/19 00:00 [received] PHST- 2025/06/21 00:00 [revised] PHST- 2025/06/25 00:00 [accepted] PHST- 2026/01/26 06:27 [medline] PHST- 2026/01/26 06:27 [pubmed] PHST- 2026/01/26 00:13 [entrez] AID - CTMC-EPUB-152700 [pii] AID - 10.2174/0115680266379551251128092015 [doi] PST - aheadofprint SO - Curr Top Med Chem. 2026 Jan 15. doi: 10.2174/0115680266379551251128092015. PMID- 41582008 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260630 IS - 1476-4954 (Electronic) IS - 1476-4954 (Linking) VI - 39 IP - 1 DP - 2026 Dec TI - Baseline serum AMH‑to‑FSH ratio, menstrual pattern, and risk of intra‑uterine adhesion recurrence: a prospective multi‑state Markov model study. PG - 2606539 LID - 10.1080/14767058.2025.2606539 [doi] AB - BACKGROUND: Intra-uterine adhesion (IUA) frequently recurs after hysteroscopic adhesiolysis, undermining menstruation and fertility. We aimed to determine whether baseline serum anti‑Mullerian hormone (AMH)‑to-follicle‑stimulating hormone (FSH) ratio and menstrual pattern independently and jointly predict IUA severity transitions after adhesiolysis using a multi‑state Markov model. METHODS: We conducted a single-center prospective study of 210 women (18-45 years) undergoing first adhesiolysis for moderate-to-severe IUA. Baseline serum AMH and FSH were measured and menstrual pattern was classified as normal, hypomenorrhea, or amenorrhea. Hysteroscopy at 3, 6, 12, and 24 months defined four severity states (none, mild, moderate, severe) and two absorbing outcomes (pregnancy >/= 12 weeks, repeat surgery). Continuous-time multi-state Markov models estimated transition-specific adjusted hazard ratios (HRs) with 95% confidence intervals (CIs), controlling for age, body-mass index (BMI), baseline adhesion severity, and adjuvant therapy. Internal validation used 200-bootstrap c-index and calibration. RESULTS: Of 210 participants, 83 women (39.5%) had any recurrence and 28 (13.3%) progressed to severe adhesions. Pregnancy >/= 12 weeks occurred in 54 (25.7%) and repeat surgery in 36 (17.1%). Each one-standard-deviation decrease in AMH/FSH increased hazards from mild to moderate (adjusted HR 1.81, 95% CI 1.29-2.54) and from moderate to severe (HR 2.15, 95% CI 1.41-3.28), with a non-significant trend from none to mild (HR 1.20, 95% CI 0.95-1.52). Amenorrhea versus normal was associated with higher hazards for none to mild (HR 1.88, 95% CI 1.23-2.99) and mild to moderate (HR 1.55, 95% CI 1.10-2.18). An interaction suggested that amenorrhea amplified the adverse effect of a low AMH/FSH ratio on progression to severe disease (HR 1.39, 95% CI 1.03-1.88). The model showed good performance, with bootstrap‑corrected C‑index 0.78 (95% CI 0.74-0.82), optimism‑corrected C‑index 0.76, and optimism‑corrected calibration slope 0.94. CONCLUSIONS: Baseline endocrine status summarized by the AMH/FSH ratio and menstrual pattern independently and jointly predict IUA dynamics after adhesiolysis. A biomarker-based, multi-state risk tool may help personalize severity-anchored surveillance and re-intervention after adhesiolysis. FAU - Li, Jiying AU - Li J AD - Department of Gynecology, The Third People's Hospital of Yunnan Province, Kunming, Yunnan, China. FAU - Yan, Jin AU - Yan J AD - Department of Reproductive Medicine, Kunming Medical University Second Affiliated Hospital, Kunming, Yunnan, China. FAU - Hu, Hongwen AU - Hu H AD - Department of Gynecology, The Third People's Hospital of Yunnan Province, Kunming, Yunnan, China. FAU - Li, Yin AU - Li Y AD - Department of Gynecology, The Third People's Hospital of Yunnan Province, Kunming, Yunnan, China. FAU - Yang, Xiao AU - Yang X AD - Department of Gynecology, The Third People's Hospital of Yunnan Province, Kunming, Yunnan, China. FAU - Dong, Chaoyu AU - Dong C AD - Department of Gynecology, The Third People's Hospital of Yunnan Province, Kunming, Yunnan, China. FAU - Guo, Ziyu AU - Guo Z AD - Department of Gynecology, The Third People's Hospital of Yunnan Province, Kunming, Yunnan, China. FAU - Shen, Huanhuan AU - Shen H AD - Department of Gynecology, The Third People's Hospital of Yunnan Province, Kunming, Yunnan, China. LA - eng PT - Journal Article DEP - 20260125 PL - England TA - J Matern Fetal Neonatal Med JT - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JID - 101136916 RN - 80497-65-0 (Anti-Mullerian Hormone) RN - 9002-68-0 (Follicle Stimulating Hormone) SB - IM MH - Humans MH - Female MH - Tissue Adhesions/blood/surgery MH - Adult MH - Prospective Studies MH - *Anti-Mullerian Hormone/blood MH - Markov Chains MH - Recurrence MH - *Follicle Stimulating Hormone/blood MH - Young Adult MH - Adolescent MH - *Uterine Diseases/blood/surgery MH - Middle Aged MH - Pregnancy MH - Hysteroscopy/adverse effects MH - Menstruation OTO - NOTNLM OT - AMH/FSH ratio OT - Asherman syndrome OT - Intra-uterine adhesion OT - menstrual pattern OT - multi-state Markov model EDAT- 2026/01/26 00:33 MHDA- 2026/01/26 00:34 CRDT- 2026/01/25 21:32 PHST- 2026/01/26 00:34 [medline] PHST- 2026/01/26 00:33 [pubmed] PHST- 2026/01/25 21:32 [entrez] AID - 10.1080/14767058.2025.2606539 [doi] PST - ppublish SO - J Matern Fetal Neonatal Med. 2026 Dec;39(1):2606539. doi: 10.1080/14767058.2025.2606539. Epub 2026 Jan 25. PMID- 41581003 OWN - NLM STAT- MEDLINE DCOM- 20260609 LR - 20260609 IS - 1099-0968 (Electronic) IS - 1072-4133 (Linking) VI - 34 IP - 4 DP - 2026 Jul TI - Early Response to an Integrated Family and Adolescent-Focussed Treatment for Anorexia Nervosa and Atypical Anorexia Nervosa. PG - 946-951 LID - 10.1002/erv.70085 [doi] AB - OBJECTIVE: Recovery rates for adolescent anorexia nervosa (AN) remain poor, requiring creativity within the field to explore alternative treatment options. One novel, evidence-informed approach integrates both family/parent and individual adolescent-focussed treatment components, through an individualised developmental lens. This study aimed to offer preliminary insights on early response to Adolescent and Parent Treatment (APT) in terms of 8-week weight trajectory. METHOD: A naturalistic, repeated measures design was employed. Twenty-four adolescents with AN or atypical AN receiving APT as standard care were identified from a specialist private outpatient clinic. Anthropometrics and psychometrics were collected at baseline, with repeat anthropometrics 8-week later. RESULTS: A significant increase in weight was found from baseline to 8-week follow-up (2.57 kg; p < 0.001), with a large effect size (d = 1.22). No associations were found between baseline clinical features and degree of weight recovery. CONCLUSIONS: This small, exploratory study provides preliminary support for meaningful early weight recovery in APT, at a similar trajectory to that found in current first line treatment. This suggests little consequence to early weight recovery goals when integrating individual psychological support with the adolescent alongside parent-lead re-feeding, from the start of treatment. Further empirical investigation of the treatment package is indicated. CI - (c) 2026 The Author(s). European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd. FAU - Roberts, Marion E AU - Roberts ME AD - Department of General Practice & Primary Healthcare, Faculty of Medical & Health Sciences, The University of Auckland, Auckland, New Zealand. FAU - Brandeis, Sarah L AU - Brandeis SL AD - Department of General Practice & Primary Healthcare, Faculty of Medical & Health Sciences, The University of Auckland, Auckland, New Zealand. LA - eng PT - Journal Article DEP - 20260125 PL - England TA - Eur Eat Disord Rev JT - European eating disorders review : the journal of the Eating Disorders Association JID - 9436977 SB - IM MH - Humans MH - *Anorexia Nervosa/therapy/psychology MH - Adolescent MH - Female MH - *Family Therapy/methods MH - Treatment Outcome MH - Male MH - Parents/psychology EDAT- 2026/01/25 08:56 MHDA- 2026/06/10 06:54 CRDT- 2026/01/25 05:22 PHST- 2026/01/09 00:00 [revised] PHST- 2025/10/13 00:00 [received] PHST- 2026/01/17 00:00 [accepted] PHST- 2026/06/10 06:54 [medline] PHST- 2026/01/25 08:56 [pubmed] PHST- 2026/01/25 05:22 [entrez] AID - 10.1002/erv.70085 [doi] PST - ppublish SO - Eur Eat Disord Rev. 2026 Jul;34(4):946-951. doi: 10.1002/erv.70085. Epub 2026 Jan 25. PMID- 41580653 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260813 IS - 1471-2377 (Electronic) IS - 1471-2377 (Linking) VI - 26 IP - 1 DP - 2026 Jan 24 TI - Serum creatinine to cystatin C ratio as a biomarker for monitoring motor-function in children with spinal muscular atrophy treated with nusinersen: a retrospective cohort study. PG - 120 LID - 10.1186/s12883-026-04657-3 [doi] LID - 120 AB - OBJECTIVE: To validate the clinical utility of creatinine-to-cystatin C ratio (CCR) as a biomarker for monitoring nusinersen treatment response in Chinese paediatric patients receiving nusinersen monotherapy. METHODS: In this retrospective, single-center study, 33 genetically confirmed 5q-SMA patients (/= 26 months (2020.2-2025.6) were enrolled. Motor function was serially evaluated using the Hammersmith Functional Motor Scale Expanded (HFMSE), Revised Upper Limb Module (RULM), and Hammersmith Infant Neurological Exam Part 2 (HINE-2). Serum biomarkers, such as creatinine (Cr), creatine kinase (CK), and cystatin C, were measured at multiple time points. A linear mixed-effects model (adjusted for age, body mass index, SMA type, and treatment duration) was used to assess the biomarker-function associations. RESULTS: Ambulant patients and those with four SMN2 copies demonstrated elevated CCR and Cr levels compared to non-ambulant patients and those with three SMN2 copies at baseline. Serum CCR levels were significantly higher than the baseline at V4-V8 (10-26 months). Cr levels were significantly higher than the baseline at V8 (26 months), whereas CK and cystatin C levels remained unchanged. In the fully adjusted linear mixed-effects models, both CCR and Cr were positively associated with HFMSE and RULM scores. However, only CCR remained significant after adjustment. Cystatin C levels were inversely correlated with the HINE-2 scores. CONCLUSION: CCR is a promising biomarker in paediatric SMA patients receiving nusinersen monotherapy; however, its validity and generalizability require confirmation in larger, more diverse multicenter cohorts. CI - (c) 2026. The Author(s). FAU - Zhang, Yuan Yuan AU - Zhang YY AD - Department of Paediatrics, Affiliated Liaocheng Second People's Hospital of Shandong First Medical University, Liaocheng, Shandong Province, China. FAU - Wang, Jie AU - Wang J AD - Department of Neurology, Jinan Children's Hospital (Children's Hospital Affiliated to Shandong University), Jinan, Shandong Province, China. FAU - Cui, Zhen Qiong AU - Cui ZQ AD - Department of Neurology, Jinan Children's Hospital (Children's Hospital Affiliated to Shandong University), Jinan, Shandong Province, China. FAU - Ma, Kai AU - Ma K AD - Department of Neurology, Jinan Children's Hospital (Children's Hospital Affiliated to Shandong University), Jinan, Shandong Province, China. shdhmmk@126.com. LA - eng PT - Journal Article DEP - 20260124 PL - England TA - BMC Neurol JT - BMC neurology JID - 100968555 RN - 0 (Cystatin C) RN - 5Z9SP3X666 (nusinersen) RN - 0 (Oligonucleotides) RN - 0 (Biomarkers) RN - AYI8EX34EU (Creatinine) SB - IM MH - Humans MH - *Cystatin C/blood MH - Retrospective Studies MH - *Oligonucleotides/therapeutic use MH - Female MH - Male MH - Biomarkers/blood MH - Child MH - *Creatinine/blood MH - Child, Preschool MH - *Muscular Atrophy, Spinal/drug therapy/blood/physiopathology MH - Adolescent MH - Infant MH - Treatment Outcome MH - *Spinal Muscular Atrophies of Childhood/drug therapy/blood PMC - PMC12910726 OTO - NOTNLM OT - Children OT - Creatinine-to-cystatin C ratio OT - Nusinersen OT - Retrospective cohort study OT - Serum biomarkers OT - Spinal muscular atrophy COIS- Declarations. Ethics approval and consent to participate: This study was conducted in full compliance with the ethical principles outlined in the Helsinki Declaration. The study protocol was approved by the Ethics Committee of Jinan Children's Hospital (approval no.SDFE-IRB/T-2025105). Written informed consent was obtained from the parents or legal guardians, and assent was obtained from the children when it was developmentally appropriate. Consent for publication: The participants in this study and all authors of this article provided consent for the publication of this article. Competing interests: The authors declare no competing interests. EDAT- 2026/01/25 00:37 MHDA- 2026/02/18 10:07 PMCR- 2026/01/24 CRDT- 2026/01/24 23:24 PHST- 2025/09/04 00:00 [received] PHST- 2026/01/13 00:00 [accepted] PHST- 2026/02/18 10:07 [medline] PHST- 2026/01/25 00:37 [pubmed] PHST- 2026/01/24 23:24 [entrez] PHST- 2026/01/24 00:00 [pmc-release] AID - 10.1186/s12883-026-04657-3 [pii] AID - 4657 [pii] AID - 10.1186/s12883-026-04657-3 [doi] PST - epublish SO - BMC Neurol. 2026 Jan 24;26(1):120. doi: 10.1186/s12883-026-04657-3. PMID- 41579526 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260730 IS - 1532-8171 (Electronic) IS - 0735-6757 (Linking) VI - 102 DP - 2026 Apr TI - A global perspective on the accuracy of pediatric weight estimation methods in emergency care: A systematic review. PG - 81-89 LID - S0735-6757(26)00039-2 [pii] LID - 10.1016/j.ajem.2026.01.030 [doi] AB - INTRODUCTION: In pediatric emergency services, it is essential to know the patient's weight, for which there are numerous estimation tools. However, these instruments present biases in calculating the patient's weight. Therefore, the objective of this study was to evaluate the validity of pediatric weight estimation methods available worldwide, comparing their accuracy and applicability in medical practice. METHODS: A systematic review was conducted following the PRISMA recommendations (PROSPERO Registration Number CRD420251174686). Observational and validation studies with original data published from 2010 to July 2025 were included. Articles were searched for in ProQuest, Web of Science, PubMed/Medline, and Scopus. The inclusion criteria were: patients aged 0 to 18 years, weight estimation methods, and quantitative reports of accuracy. RESULTS: Thirty-one studies from all continents were selected. Two-dimensional methods were generally more accurate than those based solely on age or one-dimensional formulas, especially in populations with a high prevalence of overweight or obesity. Parental estimation also performed well. Heterogeneity was observed in age ranges, acceptable error and validation criteria between studies. CONCLUSIONS: Within the limitations of the uneven global evidence base, the tools that appear most reliable for estimating pediatric weight in emergency departments are those that incorporate more than one anthropometric variable or are supported by local validation. Given the scarcity of data from various regions and specific populations, each emergency system must determine the approach that best suits its local demographic profile, invest in staff training, and apply standardized validation criteria before adopting changes in routine practice. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Fernandez-Aedo, Irrintzi AU - Fernandez-Aedo I AD - Biobizkaia Health Research Institute (IIS Biobizkaia), Plaza de Cruces s/n, Barakaldo, Bizkaia 48903, Spain; Nursing I department, Faculty of Medicine and Nursing, University of the Basque Country (EHU), Spain. FAU - Ballesteros-Pena, Sendoa AU - Ballesteros-Pena S AD - Biobizkaia Health Research Institute (IIS Biobizkaia), Plaza de Cruces s/n, Barakaldo, Bizkaia 48903, Spain; Nursing I department, Faculty of Medicine and Nursing, University of the Basque Country (EHU), Spain; Hospital Santa Marina, Osakidetza - Basque Health Service, Carretera Santa Marina 41, Bilbao, Bizkaia 48004, Spain. FAU - Tobar-Cabrera, Sandra AU - Tobar-Cabrera S AD - Nursing department, Faculty of Health Sciences, University of Tarapaca, Iquique, Chile. FAU - Vallejo-De la Hoz, Gorka AU - Vallejo-De la Hoz G AD - Biobizkaia Health Research Institute (IIS Biobizkaia), Plaza de Cruces s/n, Barakaldo, Bizkaia 48903, Spain; Nursing I department, Faculty of Medicine and Nursing, University of the Basque Country (EHU), Spain; Hospital Universitario Galdakao-Usansolo, Osakidetza - Basque Health Service, Barrio Labeaga 46-A, Galdakao, Bizkaia 48960, Spain. FAU - Fernandez-Alonso, Julia AU - Fernandez-Alonso J AD - Biobizkaia Health Research Institute (IIS Biobizkaia), Plaza de Cruces s/n, Barakaldo, Bizkaia 48903, Spain; Physiology department, Faculty of Medicine and Nursing, University of the Basque Country (EHU), Spain. Electronic address: Julia.fernandez@ehu.eus. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260120 PL - United States TA - Am J Emerg Med JT - The American journal of emergency medicine JID - 8309942 SB - IM MH - Humans MH - Child MH - *Body Weight MH - *Emergency Service, Hospital MH - Child, Preschool MH - Infant MH - *Anthropometry/methods MH - Adolescent MH - *Emergency Medical Services MH - Reproducibility of Results MH - Infant, Newborn OTO - NOTNLM OT - Anthropometry OT - Body weight OT - Emergency medicine OT - Pediatrics COIS- Declaration of competing interest None. EDAT- 2026/01/25 00:37 MHDA- 2026/02/22 05:35 CRDT- 2026/01/24 18:04 PHST- 2025/11/08 00:00 [received] PHST- 2025/12/10 00:00 [revised] PHST- 2026/01/17 00:00 [accepted] PHST- 2026/02/22 05:35 [medline] PHST- 2026/01/25 00:37 [pubmed] PHST- 2026/01/24 18:04 [entrez] AID - S0735-6757(26)00039-2 [pii] AID - 10.1016/j.ajem.2026.01.030 [doi] PST - ppublish SO - Am J Emerg Med. 2026 Apr;102:81-89. doi: 10.1016/j.ajem.2026.01.030. Epub 2026 Jan 20. PMID- 41578519 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 4 DP - 2026 Jan 23 TI - Development and validation of a logistic regression model for predicting menstrual irregularity using LDL-C and age in reproductive-aged women: An analysis of NHANES Data. PG - e46939 LID - 10.1097/MD.0000000000046939 [doi] LID - e46939 AB - Menstrual irregularity is a common reproductive endocrine disorder among women of reproductive age, serving both as an early indicator of various gynecological diseases and a potential marker of underlying metabolic disturbances. Low-density lipoprotein cholesterol (LDL-C), a key indicator of lipid metabolism, lacks robust epidemiological evidence regarding its association with menstrual irregularity. This study utilized data from the 2013 to 2014 cycle of the National Health and Nutrition Examination Survey, which included (n = 623) women aged 15 to 49 years, to train a logistic regression model for assessing the association between LDL-C levels and menstrual irregularity. The model was externally validated using data from the 2009 to 2010 cycle (n = 799). Model performance was evaluated using the area under the receiver operating characteristic curve (area under the curve [AUC]), calibration plots, and confusion matrices. A nomogram was constructed to enhance clinical interpretability. The analysis indicated that LDL-C levels and age were significant predictors of menstrual irregularity. The AUCs of the model were 0.754 in the training set and 0.765 in the validation set, demonstrating good predictive performance and robustness. Residual analysis and collinearity diagnostics further supported the good fit of the model. The nomogram based on the final model enables visualized assessment of individual risk, aiding clinical risk stratification and decision-making. Elevated LDL-C levels are significantly associated with menstrual irregularity in women of reproductive age, suggesting its potential role as a metabolic biomarker of reproductive health. Longitudinal studies are recommended to clarify the causal relationship and to explore the potential of lipid-lowering interventions in menstrual regulation. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Zou, Yafeng AU - Zou Y AUID- ORCID: 0009-0005-4448-5075 AD - Jiangxi University of Traditional Chinese Medicine, Nanchang, China. FAU - Peng, Jiahua AU - Peng J AUID- ORCID: 0000-0002-8741-397 AD - Institute of Gynecology and Obstetrics of Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China. FAU - Li, Peishuang AU - Li P AD - Institute of Gynecology and Obstetrics of Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China. AD - Department of Gynecology, The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China. FAU - Xu, Ling AU - Xu L AD - The Second Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China. FAU - Peng, Xuemei AU - Peng X AD - The Second Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China. FAU - Liang, Ruining AU - Liang R AUID- ORCID: 0000-0002-8775-4918 AD - Institute of Gynecology and Obstetrics of Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China. AD - Department of Gynecology, The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China. AD - The Second Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China. LA - eng GR - No. 20223BBG71012/Jiangxi Provincial Science and Technology Department aeurooeRevealing the Banner and Hanging the Spearaeuro Project/ PT - Journal Article PT - Validation Study PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R RN - 0 (Cholesterol, LDL) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Adult MH - Logistic Models MH - Middle Aged MH - *Cholesterol, LDL/blood MH - *Menstruation Disturbances/blood/diagnosis/epidemiology MH - Adolescent MH - Nutrition Surveys MH - Young Adult MH - Age Factors MH - Biomarkers/blood MH - ROC Curve MH - Nomograms PMC - PMC12851681 OTO - NOTNLM OT - NHANES OT - low-density lipoprotein cholesterol OT - menstrual irregularity OT - metabolic disorders OT - reproductive health COIS- The authors have no conflicts of interest to disclose. EDAT- 2026/01/24 06:35 MHDA- 2026/01/24 06:36 PMCR- 2026/01/23 CRDT- 2026/01/24 01:02 PHST- 2025/08/17 00:00 [received] PHST- 2025/11/12 00:00 [accepted] PHST- 2026/01/24 06:36 [medline] PHST- 2026/01/24 06:35 [pubmed] PHST- 2026/01/24 01:02 [entrez] PHST- 2026/01/23 00:00 [pmc-release] AID - 00005792-202601230-00065 [pii] AID - MD-D-25-10100 [pii] AID - 10.1097/MD.0000000000046939 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Jan 23;105(4):e46939. doi: 10.1097/MD.0000000000046939. PMID- 41578413 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Jan 23 TI - Effects of wrestling training on psychological well-being, anxiety, and resilience in adolescent boys. PG - 239 LID - 10.1186/s40359-026-03962-3 [doi] LID - 239 AB - BACKGROUND: Wrestling is a physically and mentally demanding combat sport that requires discipline, focus, and emotional control. Although its physiological effects are well documented, its psychological benefits in adolescents remain underexplored. This study aimed to examine whether a short-term, non-competitive wrestling program could enhance psychological well-being, reduce sport anxiety, and strengthen resilience in adolescent boys. METHODS: Thirty sedentary male adolescents (aged 12-15 years) were randomly assigned to a wrestling training group (n = 15) or a control group (n = 15). The intervention consisted of six weeks of supervised wrestling sessions performed three times per week. Psychological well-being (WHO-5), sport anxiety (SAS-2), and resilience (BPRS) were assessed before and after the intervention using the validated Turkish versions of the scales. Two-way repeated-measures ANOVA was used to analyze group x time interactions. RESULTS: Participants in the wrestling group demonstrated significant improvements in well-being (p < 0.001) and resilience (p < 0.001), alongside marked reductions in total sport anxiety and its subdimensions (p < 0.001), compared with the control group. All effects were large (etap(2) = 0.52-0.94). CONCLUSION: A structured six-week wrestling program produced meaningful psychological benefits in adolescent boys. Regular participation in non-competitive wrestling may serve as an effective approach to promote well-being, emotional stability, and adaptive coping skills during early adolescence, supporting the preventive and developmental role of combat sports in youth mental health. TRIAL REGISTRATION: Effects of wrestling training on psychological well-being, anxiety, and Resilience in Adolescent Boys. NCT07193121, Date: 12-09-2025. FAU - Ozkan, Ridvan AU - Ozkan R AD - Faculty of Sports Sciences, Kastamonu University, Kastamonu, Turkey. FAU - Yilmaz, Coskun AU - Yilmaz C AUID- ORCID: 0000-0002-2826-1566 AD - Kelkit Aydin Dogan Vocational School, Gumushane University, P.O. Box 29600, Gumushane, 24, Turkiye, Turkey. coskun.yilmaz@gumushane.edu.tr. FAU - Uzun, Recep Nur AU - Uzun RN AUID- ORCID: 0000-0002-0825-8722 AD - Yasar Dogu Faculty of Sport Sciences, Ondokuz Mayis University, Samsun, Turkey. FAU - Bayrakdaroglu, Serdar AU - Bayrakdaroglu S AUID- ORCID: 0000-0002-2166-6675 AD - Faculty of Sports Sciences, Gumushane University, Gumushane, Turkey. FAU - Akar, Ozge Orhan AU - Akar OO AD - Faculty of Sports Sciences, Kastamonu University, Kastamonu, Turkey. FAU - Oz, Faik AU - Oz F AUID- ORCID: 0009-0008-8883-2130 AD - Faculty of Sport Sciences, Avrasya University, Trabzon, Turkey. FAU - Cicekli, Atif AU - Cicekli A AD - Governorship of Amasya, Amasya, Turkey. FAU - Cicekli, Aylin AU - Cicekli A AD - Faculty of Sociology, Akdeniz University, Antalya, Turkey. FAU - Dal, Suzan AU - Dal S AUID- ORCID: 0000-0002-7732-9846 AD - Cerrahpasa Faculty of Sports Sciences, Istanbul University, Istanbul, Turkey. FAU - Ursu, Vasile Emil AU - Ursu VE AUID- ORCID: 0000-0003-2805-031X AD - Department of Physical Education and Sport, Faculty of Law and Social Sciences, University "1 Decembrie 1918" of Alba Iulia, Alba Iulia, Romania. vasile.ursu@uab.ro. FAU - Citozi, Robert AU - Citozi R AUID- ORCID: 0000-0003-3707-222X AD - Faculty of Physical Activity and Recreation, Sports University of Tirana, Tirane, Albania. FAU - Geanta, Vlad Adrian AU - Geanta VA AUID- ORCID: 0000-0002-8488-1698 AD - Department of Physical Education and Sport, Faculty of Physical Education and Sport, Aurel Vlaicu University of Arad, Arad, 310330, Romania. LA - eng SI - ClinicalTrials.gov/NCT07193121 PT - Journal Article PT - Randomized Controlled Trial DEP - 20260123 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Male MH - *Wrestling/psychology MH - Adolescent MH - *Psychological Well-Being MH - *Resilience, Psychological MH - *Anxiety/psychology/prevention & control/therapy MH - Child PMC - PMC12911033 OTO - NOTNLM OT - Adolescents OT - Anxiety OT - Combat sports OT - Mental health OT - Psychological resilience OT - Short-term effects OT - Well-being OT - Wrestling COIS- Declarations. Ethics approval and consent to participate: The study protocol was reviewed and approved by the Ethics Committee of Gumushane University (Approval No: 2025/6, dated June 25, 2025). The research was conducted in accordance with institutional guidelines, national legislation, and the ethical principles outlined in the Declaration of Helsinki. Written informed consent was obtained from all participants and their legal guardians prior to participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/24 06:36 MHDA- 2026/06/27 06:46 PMCR- 2026/01/23 CRDT- 2026/01/24 00:08 PHST- 2025/11/30 00:00 [received] PHST- 2026/01/05 00:00 [accepted] PHST- 2026/06/27 06:46 [medline] PHST- 2026/01/24 06:36 [pubmed] PHST- 2026/01/24 00:08 [entrez] PHST- 2026/01/23 00:00 [pmc-release] AID - 10.1186/s40359-026-03962-3 [pii] AID - 3962 [pii] AID - 10.1186/s40359-026-03962-3 [doi] PST - epublish SO - BMC Psychol. 2026 Jan 23;14(1):239. doi: 10.1186/s40359-026-03962-3. PMID- 41578367 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260130 LR - 20260131 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 14 IP - 1 DP - 2026 Jan 23 TI - Eating disorders and disordered eating behaviour in older adults: a scoping review. PG - 36 LID - 10.1186/s40337-025-01486-6 [doi] LID - 36 AB - BACKGROUND: Eating disorders (ED) and disordered eating behaviours (DEB) in older adults have important implications for physical morbidity and mortality. Thus far, there has been no attempt to systematically evaluate the research landscape of ED and DEB in older adults. METHODS: A scoping review adhering to PRISMA-ScR reporting standards was conducted. We searched MEDLINE, Google Scholar, and PsycINFO (2000-2025) for English-language, peer-reviewed articles on ED/DEB in older adults covering diagnosis, epidemiology, determinants, clinical features, progression, or treatment, in any setting. RESULTS: A total of 53 publications were included in the final review, comprising four systematic reviews, five longitudinal studies, and 44 cross-sectional studies. All original studies were observational in design. Research was predominantly community-based and relied on single-step screening, limiting diagnostic validity. Healthcare facility-based studies have examined ED in patients with comorbidities such as obesity, diabetes, and those undergoing bariatric surgery. Most study participants were Caucasian, with limited representation from minority groups. ED in older adults were mostly in women, with presentations characterised by dietary restriction, binge-purge behaviours, and body image preoccupation. The data on prevalence of subtypes of ED was variably reported. Most late-onset cases were precipitated by psychosocial stressors such as bereavement, caregiving responsibilities, or social isolation. Biological factors, particularly menopausal age in women, were found to be associated with an increased prevalence of DEBs, such as binge eating and restrictive eating patterns. Comorbid depression, anxiety, and medical conditions were frequent. Combined behavioural and pharmacological interventions offered better outcomes. Poorer outcomes were linked to chronicity, low body mass index, presence of comorbidities, and poor treatment engagement. Protective factors, including cognitive adaptation and positive attitudes toward ageing, may confer resilience. CONCLUSION: ED and DEB in older adults are a significant but underrecognized public health issue. Existing research is constrained by limited diversity, Western-centric samples, and reliance on self-reported measures, underscoring the urgent need for inclusive, longitudinal, and interventional studies that better capture biopsychosocial determinants of EDs and DEBs, while also promoting the provision of age-sensitive care. CI - (c) 2026. The Author(s). FAU - Vaidyanathan, Sivapriya AU - Vaidyanathan S AUID- ORCID: 0000-0002-2793-0537 AD - Department of Psychiatry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. FAU - Purohith Narasimhan, Abhiram AU - Purohith Narasimhan A AUID- ORCID: 0000-0002-0265-2147 AD - Department of Psychiatry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. FAU - Mynampally, Keerthana AU - Mynampally K AD - Department of Psychiatry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. FAU - Menon, Vikas AU - Menon V AUID- ORCID: 0000-0001-8035-4658 AD - Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605006, India. drvmenon@gmail.com. LA - eng PT - Journal Article PT - Review DEP - 20260123 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC12853710 OAB - Eating disorders are often thought to affect only teenagers and young adults, but research shows that they also occur in older adults. This review looked at studies published since 2000 on eating disorders and disordered eating in people aged 50 and above. We found 53 studies, but most were small and observational in design. Most participants were women, and very few studies included people from minority groups.Traditionally, eating disorders were more common in women after stressful life events such as bereavement, caregiving pressures, or social isolation. Biological changes, such as menopause also contributed to the onset. Depression, anxiety, and physical health problems frequently occurred alongside eating disorders. Treatment typically involved a combination of talking therapies and medication, with combined approaches yielding better results.Our findings show that eating disorders in older adults are an important but overlooked health issue. Greater awareness, more ethnically inclusive research, and tailored support can help older people manage these conditions and improve recovery. OABL- eng OTO - NOTNLM OT - Disordered eating OT - Eating disorders OT - Eating habits OT - Elderly OT - Geriatric OT - Late life OT - Older adults COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/24 06:35 MHDA- 2026/01/24 06:36 PMCR- 2026/01/23 CRDT- 2026/01/24 00:06 PHST- 2025/08/30 00:00 [received] PHST- 2025/11/25 00:00 [accepted] PHST- 2026/01/24 06:36 [medline] PHST- 2026/01/24 06:35 [pubmed] PHST- 2026/01/24 00:06 [entrez] PHST- 2026/01/23 00:00 [pmc-release] AID - 10.1186/s40337-025-01486-6 [pii] AID - 1486 [pii] AID - 10.1186/s40337-025-01486-6 [doi] PST - epublish SO - J Eat Disord. 2026 Jan 23;14(1):36. doi: 10.1186/s40337-025-01486-6. PMID- 41578297 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1472-6874 (Electronic) IS - 1472-6874 (Linking) VI - 26 IP - 1 DP - 2026 Jan 23 TI - Health-related quality of life (HRQoL) and associated factors among women with polycystic ovary syndrome (PCOS) attending an infertility center in Nepal: a cross-sectional study. PG - 109 LID - 10.1186/s12905-026-04280-x [doi] LID - 109 AB - BACKGROUND: Polycystic ovary syndrome (PCOS) significantly impairs women's health -related quality of life (HRQoL), yet evidence from Nepal remains limited. This study aimed to assess HRQoL and associated factors among women with PCOS attending an infertility center in Kathmandu, Nepal. METHODS: A hospital-based cross-sectional study was conducted from March to September 2023 among 135 women aged 18-45 years diagnosed with PCOS, selected through simple random sampling. Data were collected through face-to-face interviews using validated instruments: the Polycystic Ovary Syndrome Questionnaire (PCOSQ), the International Physical Activity Questionnaire-Short Form (IPAQ-SF), and the Perceived Stress Scale (PSS-4). Statistical analyses included descriptive statistics, bivariate analyses, and multiple linear regression to identify the factors associated with HRQoL. RESULTS: The mean overall HRQoL score was 5.04 +/- 1.44 on a 7-point scale, with the lowest domain scores observed for infertility (3.34 +/- 1.72), emotional well-being (4.29 +/- 0.97), and menstruation (4.32 +/- 1.13) domains, while the body hair domain was least affected (8.58 +/- 1.86). In adjusted regression, younger age, marital status, higher BMI, acne, menstrual irregularities, fertility-related history, physical inactivity, substance use, and high stress were significantly associated with poorer HRQoL (p < 0.05). CONCLUSION: Women with PCOS in Nepal experience significant impairment in HRQoL, most notably in relation to infertility, emotional well-being, and menstrual irregularities. Both modifiable and non-modifiable factors were associated with poorer HRQoL. These findings highlight the need for a holistic, patient-centered approach that integrates medical, psychological, and lifestyle interventions, particularly in resource-limited settings. FAU - Marasine, Nirmal Raj AU - Marasine NR AUID- ORCID: 0000-0003-4353-382X AD - Department of Pharmacy, CiST College, Pokhara University, Kathmandu, 44600, Nepal. nirmalmarasine@gmail.com. FAU - Aryal, Ambika AU - Aryal A AD - Department of Pharmacy, CiST College, Pokhara University, Kathmandu, 44600, Nepal. FAU - Mahat, Salma AU - Mahat S AD - Department of Pharmacy, CiST College, Pokhara University, Kathmandu, 44600, Nepal. FAU - Gc, Shreejana AU - Gc S AD - Department of Pharmacy, CiST College, Pokhara University, Kathmandu, 44600, Nepal. FAU - Thakuri, Supriya Singh AU - Thakuri SS AD - Department of Pharmacy, CiST College, Pokhara University, Kathmandu, 44600, Nepal. FAU - Pathak, Nabin AU - Pathak N AD - Department of Pharmacy and Clinical Pharmacology, Madan Bhandari Academy of Health Sciences, Hetauda, Nepal. FAU - Paudel, Shishir AU - Paudel S AD - Department of Public Health, CiST College, Pokhara University, Kathmandu, 44600, Nepal. FAU - Sankhi, Sabina AU - Sankhi S AD - Department of Pharmacy, Shree College of Technology, Purbanchal University , Bharatpur-12, Chitwan, 44200, Nepal. LA - eng PT - Journal Article DEP - 20260123 PL - England TA - BMC Womens Health JT - BMC women's health JID - 101088690 SB - IM MH - Humans MH - Female MH - *Quality of Life/psychology MH - *Polycystic Ovary Syndrome/psychology/complications MH - Cross-Sectional Studies MH - Adult MH - Nepal MH - Young Adult MH - Adolescent MH - Surveys and Questionnaires MH - *Infertility, Female/psychology MH - Middle Aged PMC - PMC12910849 OTO - NOTNLM OT - Associated factors OT - Health-related quality of life OT - Infertility center OT - Polycystic ovary syndrome OT - Women COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Institutional Review Committee of CiST (IRC-CiST, Ref no. 66/079/080), and data collection permission was taken from the Infertility Center at Bijulibazar, Kathmandu. Written informed consent was obtained from all participants prior to data collection. For participants who could not read or write, the consent form was read aloud in the Nepali language in the presence of an impartial witness, who then signed the form; participants provided consent by affixing a thumbprint. Consent for publication: N/A. Competing interests: The authors declare no competing interests. EDAT- 2026/01/24 06:35 MHDA- 2026/06/27 18:38 PMCR- 2026/01/23 CRDT- 2026/01/24 00:02 PHST- 2025/06/02 00:00 [received] PHST- 2026/01/11 00:00 [accepted] PHST- 2026/06/27 18:38 [medline] PHST- 2026/01/24 06:35 [pubmed] PHST- 2026/01/24 00:02 [entrez] PHST- 2026/01/23 00:00 [pmc-release] AID - 10.1186/s12905-026-04280-x [pii] AID - 4280 [pii] AID - 10.1186/s12905-026-04280-x [doi] PST - epublish SO - BMC Womens Health. 2026 Jan 23;26(1):109. doi: 10.1186/s12905-026-04280-x. PMID- 41576020 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260123 LR - 20260126 IS - 2767-3375 (Electronic) IS - 2767-3375 (Linking) VI - 6 IP - 1 DP - 2026 TI - Prevalence and its associated factors of inadequate dietary diversity among pregnant women attending antenatal care in selected public health facilities in Addis Ababa, Ethiopia. PG - e0005575 LID - 10.1371/journal.pgph.0005575 [doi] LID - e0005575 AB - Adequate dietary diversity during pregnancy is crucial for the well-being and growth of both the mother and the child. Many pregnant women in Ethiopia, including in Addis Ababa, suffer from poor dietary diversity and associated malnutrition. However, previous studies conducted in Addis Ababa are limited in scope. Therefore, this study assessed inadequate dietary diversity and its associated factors among pregnant women attending antenatal care in selected public health facilities in Addis Ababa, Ethiopia. A facility-based cross-sectional study was carried out among 615 pregnant women in Addis Ababa who were receiving antenatal care at selected public health facilities. A systematic random sampling technique was used to select the study participants. Data were collected using a structured pretested questionnaire. The validated 10 food group dietary diversity questions were used to elicit dietary diversity. This study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board (IRB) of Menelik II Medical and Health Science Collage (Ref.No.5/38/12/1985). The data were entered on Epi-info version 7.2.1.0 and exported to SPSS version 23.0 for analysis. Logistic regression analysis was used to identify factors associated with low dietary diversity. In general, 55.8% of pregnant women had inadequate dietary diversity. Significant factors included lack of education (AOR = 3.75, 95% CI: 1.96,7.15), low income (AOR = 1.67, 95% CI: 1.02,2.74), lack of nutritional counseling (AOR = 1.68, 95% CI: 1.06,2.68) and household food insecurity (AOR = 5.33,95%CI:2.05,13.81), which were factors associated with inadequate dietary diversity among pregnant women, respectively. The magnitude of inadequate dietary diversity remains high among pregnant women in Addis Ababa. Having low income, being unable to read and write, lacking counseling about dietary diversity, and having household food insecurity were significantly associated with inadequate diversified dietary. Therefore, enhancing women's education, offering counselling on dietary diversity, and implementing sustainable income-generating and food security interventions activities are crucial. CI - Copyright: (c) 2026 Mokonen, Gemaneh. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Mokonen, Zinash Getachew AU - Mokonen ZG AUID- ORCID: 0009-0009-9682-9289 AD - Deparment of Psychiatry, Addis Ababa City Administration Health Bureau, Arada Afencho ber Health Center, Addis Ababa, Ethiopia. FAU - Gemaneh, Haimanot Teferi AU - Gemaneh HT AUID- ORCID: 0000-0003-3528-689X AD - Department of Medical Laboratory, Addis Ababa City Administration Health Bureau, Bole Dil-frie Health Center, Addis Ababa, Ethiopia. LA - eng PT - Journal Article DEP - 20260123 PL - United States TA - PLOS Glob Public Health JT - PLOS global public health JID - 9918283779606676 PMC - PMC12829869 COIS- The authors have declared that no competing interests exist. EDAT- 2026/01/23 18:35 MHDA- 2026/01/23 18:36 PMCR- 2026/01/23 CRDT- 2026/01/23 13:44 PHST- 2025/09/04 00:00 [received] PHST- 2026/01/05 00:00 [accepted] PHST- 2026/01/23 18:36 [medline] PHST- 2026/01/23 18:35 [pubmed] PHST- 2026/01/23 13:44 [entrez] PHST- 2026/01/23 00:00 [pmc-release] AID - PGPH-D-25-02582 [pii] AID - 10.1371/journal.pgph.0005575 [doi] PST - epublish SO - PLOS Glob Public Health. 2026 Jan 23;6(1):e0005575. doi: 10.1371/journal.pgph.0005575. eCollection 2026. PMID- 41574950 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260818 IS - 1463-1326 (Electronic) IS - 1462-8902 (Linking) VI - 28 IP - 4 DP - 2026 Apr TI - Evaluating WHtR and WC cut-offs for abdominal obesity among children and adolescents: Insights from three National Surveys in China. PG - 3011-3019 LID - 10.1111/dom.70488 [doi] AB - AIM: To assess the application of current waist-to-height ratio (WHtR) and waist circumference (WC) evaluation criteria and identify preferred recommendations for public health practise. MATERIALS AND METHODS: Data were from three waves of the Chinese National Survey on Students Constitution and Health (CNSSCH) conducted in 2010, 2014 and 2019; abdominal obesity was classified using four WHtR and WC standards. Age- and sex-specific WHtR and WC percentile curves were generated using the LMS method. Prevalence of central adiposity by WHtR/WC and general obesity by BMI were compared. Predictive performance of the criteria was validated using an independent dataset with cardiometabolic risk factors. RESULTS: WHtR percentile curves showed a relatively flat trend with age in both sexes compared to WC curves. Abdominal obesity prevalence increased significantly from 2010 to 2019 across all criteria: international cut-off (0.46) (21.26%-27.66%), Chinese WC cut-offs (13.77%-19.64%), international WHtR cut-off (0.50) (9.12%-13.01%) and international WC cut-offs (7.95%-11.95%). All abdominal obesity criteria identified substantially more cases than BMI-based general obesity in 2019 (8.14%). The Chinese WC cut-offs showed superior predictive performance compared to the other three standards for cardiometabolic outcomes. CONCLUSIONS: The Chinese WC cut-offs and international cut-off (0.50) are optimal for childhood abdominal obesity screening in China due to their public health applicability. Standardized global criteria are urgently needed to enhance research comparability. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Zhang, Yihang AU - Zhang Y AUID- ORCID: 0009-0004-0604-8803 AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China. FAU - Cai, Shan AU - Cai S AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China. FAU - Huang, Tianyu AU - Huang T AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China. FAU - Li, Jiaxin AU - Li J AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China. FAU - Dang, Jiajia AU - Dang J AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China. FAU - Chen, Ziyue AU - Chen Z AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China. FAU - Liu, Yunfei AU - Liu Y AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China. FAU - Hu, Peijin AU - Hu P AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China. FAU - Ma, Jun AU - Ma J AUID- ORCID: 0000-0003-3529-1808 AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China. FAU - Song, Yi AU - Song Y AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China. LA - eng GR - 2024YFC2707901/National Key Research and Development Program of China/ GR - 82273654/National Natural Science Foundation of China/ PT - Journal Article DEP - 20260123 PL - England TA - Diabetes Obes Metab JT - Diabetes, obesity & metabolism JID - 100883645 SB - IM MH - Humans MH - *Obesity, Abdominal/epidemiology/diagnosis MH - Female MH - China/epidemiology MH - Male MH - Child MH - *Waist Circumference MH - Adolescent MH - *Waist-Height Ratio MH - Prevalence MH - *Pediatric Obesity/epidemiology/diagnosis MH - Body Mass Index MH - Health Surveys OTO - NOTNLM OT - cardiovascular disease OT - population study OT - primary care OT - weight management EDAT- 2026/01/23 13:05 MHDA- 2026/03/17 06:48 CRDT- 2026/01/23 08:13 PHST- 2026/01/05 00:00 [revised] PHST- 2025/10/29 00:00 [received] PHST- 2026/01/07 00:00 [accepted] PHST- 2026/03/17 06:48 [medline] PHST- 2026/01/23 13:05 [pubmed] PHST- 2026/01/23 08:13 [entrez] AID - 10.1111/dom.70488 [doi] PST - ppublish SO - Diabetes Obes Metab. 2026 Apr;28(4):3011-3019. doi: 10.1111/dom.70488. Epub 2026 Jan 23. PMID- 41574894 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261015 IS - 2168-6602 (Electronic) IS - 0890-1171 (Print) IS - 0890-1171 (Linking) VI - 40 IP - 8 DP - 2026 Nov TI - Development and Validation of the Adaptive Eating Scale: Exploratory and Confirmatory Factor Analyses. PG - 947-957 LID - 10.1177/08901171261421070 [doi] AB - PurposeAdaptive eating refers to internally regulated eating that is enjoyable and gently guided by the nutritional quality of foods. Despite growing interest in this construct, there is currently no validated scale to measure adaptive eating among US college students aged >/=18 years. This study aimed to develop and evaluate the psychometric properties of the Adaptive Eating Scale (AES) in a diverse sample of US college students.DesignThirty-seven items were developed to comprise the AES. Students completed AES and measures of intuitive eating, mental health, diet, and anthropometrics.SampleEight hundred and forty-nine university students aged >/=18 years, from racially and ethnically diverse backgrounds.AnalysisThe sample was divided randomly into two. Exploratory Factor Analysis (EFA) was completed on subsample A (n = 424). Confirmatory Factor Analysis (CFA) was conducted on subsample B (n = 425) to confirm factor structure from subsample A.ResultsEFA showed 17 items representing gentle nutrition (GN), unpreoccupied by food cravings (UBFC), enjoyment of food (EOF), and honoring hunger (HH) explained 63.1% of the variance. CFA showed a bifactor model comprising one global factor and four orthogonal factors (GN, UBFC, EOF, and HH) had excellent fit [CFI = 0.972, RMSEA = 0.051, SRMR = 0.048]. GN, EOF, and HH were reliable, and significantly associated with each other, intuitive eating, emotional eating, weight status, and mental health.ConclusionResults showed that AES is best conceptualized as a multidimensional measure with one general factor and specific factors representing GN, EOF, and HH. FAU - Zeraattalab-Motlagh, Sheida AU - Zeraattalab-Motlagh S AD - Department of Health and Human Performance, University of Houston, Houston, TX, USA. RINGGOLD: 14743 FAU - Wiesner, Margit AU - Wiesner M AD - Department of Psychological, Health, and Learning Sciences, University of Houston, Houston, TX, USA. RINGGOLD: 14743 FAU - Yoon, Cynthia AU - Yoon C AD - Department of Food Science and Nutrition, Pusan National University, Busan, Republic of Korea. RINGGOLD: 34996 FAU - Sasson, Sarah AU - Sasson S AD - Department of Health and Human Performance, University of Houston, Houston, TX, USA. RINGGOLD: 14743 FAU - Betts, Randi AU - Betts R AD - Department of Health and Human Performance, University of Houston, Houston, TX, USA. RINGGOLD: 14743 FAU - Johnston, Craig AU - Johnston C AD - Department of Health and Human Performance, University of Houston, Houston, TX, USA. RINGGOLD: 14743 FAU - Ledoux, Tracey AU - Ledoux T AD - Department of Health and Human Performance, University of Houston, Houston, TX, USA. RINGGOLD: 14743 LA - eng PT - Journal Article PT - Validation Study DEP - 20260123 PL - United States TA - Am J Health Promot JT - American journal of health promotion : AJHP JID - 8701680 SB - IM MH - Humans MH - Female MH - Factor Analysis, Statistical MH - Psychometrics MH - Male MH - Young Adult MH - *Students/psychology MH - *Feeding Behavior/psychology MH - Adolescent MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Universities MH - Mental Health PMC - PMC13646408 OTO - NOTNLM OT - US OT - college students OT - cross-sectional OT - eating behavior OT - validity COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/01/23 13:05 MHDA- 2026/10/15 07:17 PMCR- 2026/10/08 CRDT- 2026/01/23 07:52 PHST- 2026/10/15 07:17 [medline] PHST- 2026/01/23 13:05 [pubmed] PHST- 2026/01/23 07:52 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - 10.1177_08901171261421070 [pii] AID - 10.1177/08901171261421070 [doi] PST - ppublish SO - Am J Health Promot. 2026 Nov;40(8):947-957. doi: 10.1177/08901171261421070. Epub 2026 Jan 23. PMID- 41574666 OWN - NLM STAT- MEDLINE DCOM- 20260622 LR - 20260811 IS - 1461-7277 (Electronic) IS - 1359-1053 (Linking) VI - 31 IP - 8 DP - 2026 Jul TI - Unveiling the relation among mental health, dietary quality, health literacy, loneliness, physical activities, and BMI in young Chinese. PG - 3395-3409 LID - 10.1177/13591053251414515 [doi] AB - This study aims to examine the complex interrelationships among dietary quality, health literacy, loneliness, physical activity, mental health, and BMI (Body Mass Index) among young Chinese individuals, with particular attention to the mediating role of mental health in the pathways linking health behaviors and BMI. A cross-sectional survey was conducted with a diverse sample of Chinese university students (N = 1568) using validated instruments to measure dietary quality, health literacy, loneliness, physical activity, mental health, and BMI. Structural equation modeling (SEM) was employed to test both direct and indirect relationships among the variables. Findings revealed that higher levels of dietary quality, health literacy, and physical activity were significantly associated with better mental health, while loneliness showed a strong negative effect. Mental health was, in turn, negatively associated with BMI. Furthermore, mental health significantly mediated the effects of dietary quality, health literacy, and physical activity on BMI. These results underscore the central role of psychological well-being in converting health knowledge and behaviors into tangible physical outcomes. The study highlights the need for integrated health promotion strategies that address not only physical behaviors and informational competencies but also the emotional and social dimensions of health. Strengthening mental health support and health literacy among youth may enhance the effectiveness of dietary and physical activity interventions, contributing to the broader goals of the Healthy China 2030 initiative. FAU - Chen, Haifeng AU - Chen H AUID- ORCID: 0009-0009-9439-2386 AD - Northeastern University at Qinhuangdao, Hebei Province, China. AD - Northeastern University Research Institute, Qinhuangdao, Hebei Province, China. LA - eng PT - Journal Article DEP - 20260123 PL - England TA - J Health Psychol JT - Journal of health psychology JID - 9703616 SB - IM MH - Humans MH - Female MH - *Health Literacy/statistics & numerical data MH - Male MH - *Mental Health/statistics & numerical data MH - *Exercise/psychology MH - Young Adult MH - Cross-Sectional Studies MH - *Body Mass Index MH - China MH - *Loneliness/psychology MH - *Diet MH - Adolescent MH - Adult MH - Health Behavior MH - Students/psychology OTO - NOTNLM OT - BMI OT - Chinese youth OT - dietary quality OT - health literacy OT - loneliness OT - mental health OT - physical activity OT - structural equation modeling COIS- Declaration of conflicting interestsThe author declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/01/23 13:05 MHDA- 2026/06/22 13:44 CRDT- 2026/01/23 06:33 PHST- 2026/06/22 13:44 [medline] PHST- 2026/01/23 13:05 [pubmed] PHST- 2026/01/23 06:33 [entrez] AID - 10.1177/13591053251414515 [doi] PST - ppublish SO - J Health Psychol. 2026 Jul;31(8):3395-3409. doi: 10.1177/13591053251414515. Epub 2026 Jan 23. PMID- 41572802 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260630 IS - 2152-2723 (Electronic) IS - 2152-2715 (Linking) VI - 29 IP - 3 DP - 2026 Mar TI - Screen Use Measurement Tools: A Mapping of Instruments, Gaps, and Future Directions. PG - 140-150 LID - 10.1177/21522715261417288 [doi] AB - Research on screen usage frequently relies on broad measures of "screen time," which fail to differentiate between various types of activities and their effects. To clarify how digital behavior is defined, we conducted a rapid review and methodological mapping of 36 screen use measurement tools. Three independent coders applied a piloted framework to classify measurement constructs, data collection modality (objective logs, self-, or proxy-report), temporal specificity, framing valence, opportunity cost, dyadic/social context, developmental focus, and evidence of reliability and validity. Interrater agreement was high (Fleiss' Kappa; Gwet's AC1). Most instruments used negatively framed item content, emphasizing impairment, dysregulation, or loss of control, focused on adolescents and young adults, and lacked precision in temporal anchoring. Very few assessed opportunity costs, dyadic use, or included validation against device-logged data. No measure emphasized positive or beneficial aspects of screen engagement. These gaps suggest a need for more conceptually balanced tools that integrate objective tracking with context-sensitive self-report items across the lifespan. We propose a blueprint for future development: improve temporal anchoring (e.g., within-day, weekday vs. weekend), broaden age inclusion, assess social and functional context, and report both reliability and validation against behavioral data. Strengthening measurement will advance efforts to identify when, how, and for whom digital behavior supports or undermines well-being. FAU - Shaleha, Rinanda AU - Shaleha R AUID- ORCID: 0000-0001-6448-8461 AD - Department of Human Development and Family Studies, The Pennsylvania State University, University Park, Pennsylvania, USA. AD - Center for Healthy Aging, The Pennsylvania State University, University Park, Pennsylvania, USA. FAU - Roque, Nelson AU - Roque N AD - Department of Human Development and Family Studies, The Pennsylvania State University, University Park, Pennsylvania, USA. AD - Center for Healthy Aging, The Pennsylvania State University, University Park, Pennsylvania, USA. FAU - Andrews, Hailey AU - Andrews H AD - Center for Healthy Aging, The Pennsylvania State University, University Park, Pennsylvania, USA. FAU - Calfee, Kristin AU - Calfee K AD - Department of Human Development and Family Studies, The Pennsylvania State University, University Park, Pennsylvania, USA. AD - Center for Healthy Aging, The Pennsylvania State University, University Park, Pennsylvania, USA. FAU - Lee, Soomi AU - Lee S AD - Department of Human Development and Family Studies, The Pennsylvania State University, University Park, Pennsylvania, USA. AD - Center for Healthy Aging, The Pennsylvania State University, University Park, Pennsylvania, USA. LA - eng PT - Journal Article PT - Review DEP - 20260122 PL - United States TA - Cyberpsychol Behav Soc Netw JT - Cyberpsychology, behavior and social networking JID - 101528721 SB - IM MH - Humans MH - *Screen Time MH - Reproducibility of Results MH - Digital Media OTO - NOTNLM OT - device-logged data OT - digital behavior OT - lifespan development OT - measurement mapping OT - opportunity cost OT - screen use COIS- Author Disclosure StatementThe authors declare no conflicts of interest related to this study. EDAT- 2026/01/23 06:29 MHDA- 2026/03/30 06:29 CRDT- 2026/01/23 02:23 PHST- 2026/03/30 06:29 [medline] PHST- 2026/01/23 06:29 [pubmed] PHST- 2026/01/23 02:23 [entrez] AID - 10.1177/21522715261417288 [doi] PST - ppublish SO - Cyberpsychol Behav Soc Netw. 2026 Mar;29(3):140-150. doi: 10.1177/21522715261417288. Epub 2026 Jan 22. PMID- 41572776 OWN - NLM STAT- MEDLINE DCOM- 20260924 LR - 20261010 IS - 1875-6190 (Electronic) IS - 1570-159X (Print) IS - 1570-159X (Linking) VI - 24 IP - 11 DP - 2026 TI - Associations Among Binge Eating Behaviors, Emotion Regulation, and Chronotype in Female Greek University Students. PG - 1765-1776 LID - 10.2174/011570159X431924251127110942 [doi] AB - INTRODUCTION: This study aimed to examine the associations among binge eating behaviors (BEBs), emotion regulation (ER), and chronotypes, and whether ER mediates the relationship between chronotypes and BEBs in Greek female university students, a population in which these associations have not previously been investigated. METHODS: This study was approved by the Research and Ethics Committee of the Medical School of Aristotle University of Thessaloniki (No. 91/23, dated 17/02/2023). A total of 269 female students (mean age (+/-SD) = 21.07 (+/-4.36)) from Aristotle University of Thessaloniki participated in this cross-sectional study. Participants completed a sociodemographic questionnaire and four validated instruments: the Eating Disorder Examination Questionnaire, the Binge Eating Scale, the Difficulties in Emotion Regulation Scale, and the Morningness-Eveningness Questionnaire. RESULTS: BEBs were significantly correlated with eating psychopathology (rs = 0.723, p < 0.001) and with difficulties in emotion regulation (ER) (rs = 0.429, p < 0.001). ER difficulties were also associated with eating psychopathology (rs = 0.434, p < 0.001). An evening chronotype was significantly associated with greater ER difficulties (rs = -0.150, 0.014). Mediation analysis indicated that ER difficulties fully mediated the relationship between eveningness and BEBs (Indirect Effect = -0.06, 95% CI: -0.11 to -0.01). DISCUSSION: ER difficulties are associated with both BEBs and eveningness. While eveningness is not directly associated with BEBs, it is indirectly related through ER difficulties, suggesting a potential psychological mechanism underlying this relationship. CONCLUSION: ER difficulties may be a key mechanism linking evening chronotype to BEBs. Future studies could explore whether interventions targeting ER and circadian alignment are beneficial for managing BEBs among individuals with an evening chronotype. CI - Copyright(c) Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. FAU - Karakosta, Efi AU - Karakosta E AUID- ORCID: 0009-0004-2897-8243 AD - 3rd Department of Psychiatry, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Tsapakis, Evangelia-Maria AU - Tsapakis EM AUID- ORCID: 0000-0002-2649-6732 AD - 3rd Department of Psychiatry, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Konsta, Anastasia AU - Konsta A AUID- ORCID: 0000-0002-7165-5608 AD - 1st Department of Psychiatry, Papageorgiou General Hospital of Thessaloniki, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Lan, Anat AU - Lan A AUID- ORCID: 0000-0002-8547-2482 AD - School of Behavioral Sciences, Tel Aviv-Yaffo Academic College, Tel Aviv, Israel. FAU - Einat, Haim AU - Einat H AUID- ORCID: 0000-0001-7025-5541 AD - 3rd Department of Psychiatry, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece. AD - School of Behavioral Sciences, Tel Aviv-Yaffo Academic College, Tel Aviv, Israel. FAU - Fountoulakis, Konstantinos N AU - Fountoulakis KN AUID- ORCID: 0000-0001-5503-0811 AD - 3rd Department of Psychiatry, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece. LA - eng PT - Journal Article PL - United Arab Emirates TA - Curr Neuropharmacol JT - Current neuropharmacology JID - 101157239 SB - IM MH - Humans MH - Female MH - *Chronotype MH - Greece/epidemiology MH - *Students/psychology MH - Cross-Sectional Studies MH - *Emotional Regulation/physiology MH - Young Adult MH - Universities MH - *Bulimia/psychology MH - Surveys and Questionnaires MH - Adult MH - Adolescent MH - Feeding Behavior/psychology MH - Circadian Rhythm PMC - PMC13647652 OTO - NOTNLM OT - Binge eating behaviors OT - chronotypes OT - circadian rhythm OT - eating disorders OT - emotion regulation OT - evening chronotype COIS- The authors declare no conflict of interest, financial or otherwise. EDAT- 2026/01/23 06:31 MHDA- 2026/09/24 05:36 PMCR- 2026/07/13 CRDT- 2026/01/23 02:08 PHST- 2025/07/21 00:00 [received] PHST- 2025/09/28 00:00 [revised] PHST- 2025/10/07 00:00 [accepted] PHST- 2026/09/24 05:36 [medline] PHST- 2026/01/23 06:31 [pubmed] PHST- 2026/01/23 02:08 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - CN-EPUB-152577 [pii] AID - CN-24-11-1765 [pii] AID - 10.2174/011570159X431924251127110942 [doi] PST - ppublish SO - Curr Neuropharmacol. 2026;24(11):1765-1776. doi: 10.2174/011570159X431924251127110942. PMID- 41572177 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2474 (Electronic) IS - 1471-2474 (Linking) VI - 27 IP - 1 DP - 2026 Jan 22 TI - Correlation between systemic immune inflammatory index and prognostic nutritional index and prognosis of osteosarcoma patients and construction of prediction model. PG - 151 LID - 10.1186/s12891-026-09494-6 [doi] LID - 151 AB - BACKGROUND: To explore the predictive value of systemic immune inflammatory index (SII) and prognostic nutritional index (PNI) for the prognosis of patients with osteosarcoma, and to construct and validate an individualized survival prediction model. METHODS: The clinical data of osteosarcoma patients who underwent surgery in the 900th Hospital of the Joint Logistics Support Force from January 2012 to January 2020 were retrospectively analyzed. Preoperative SII (platelets x neutrophils/lymphocytes) and PNI (albumin + 5 x lymphocytes) were calculated, and the optimal cutoff values​were determined by ROC curve. The Kaplan-Meier method was used to draw survival curves to analyze their relationship with the overall survival time of patients. Pearson correlation analysis was used to analyze the correlation between SII and PNI. Cox regression analysis was used to analyze independent prognostic factors, and the nomogram model was constructed using R software and internally validated. RESULTS: The 5-year overall survival rate of the high SII group was significantly lower than that of the low SII group (27.7% vs. 87.0%, p < 0.05); the 5-year overall survival rate of the low PNI group was significantly lower than that of the high PNI group (23.1% vs. 83.6%, p < 0.05). SII was negatively correlated with PNI (r=-0.410, P < 0.001). The high SII + low PNI group had the worst prognosis, while the low SII + high PNI group had the best prognosis. Cox multivariate analysis showed that SII > 552.60, PNI /=60 ml/min per 1.73 m 2 . Predictor variables in the base model were age, sex, creatinine or eGFR, ADPKD genotype, and Mayo Imaging Class. Clinical and laboratory data were evaluated in the full model. RESULTS: The development cohort included 759 patients with baseline eGFR of 91+/-29 ml/min per 1.73 m 2 (mean+/-SD), of whom 16% reached end point after median (interquartile range) follow-up of 10.2 (5.5-16.7) years. The validation cohort included 535 patients with baseline eGFR of 90+/-31 ml/min per 1.73 m 2 (mean+/-SD), of whom 11% reached end point after median (interquartile range) follow-up of 5.5 (1.5-13.7) years. The full model, including age, sex, serum creatinine, Mayo Imaging Class, total carbon dioxide, hemoglobin, diastolic BP, and body mass index, had a C-index of 0.81 (95% confidence interval, 0.72 to 0.90) in the validation cohort and 0.75 (95% confidence interval, 0.62 to 0.88) when ADPKD genotype was also included. Risk predictions from base and full models were well-calibrated out to 15 years. CONCLUSIONS: In persons with early ADPKD and preserved eGFR, a model using routinely obtained clinical information quantified risk of kidney failure over 15 years. CI - Copyright (c) 2025 by the American Society of Nephrology. FAU - Yu, Alan S L AU - Yu ASL AUID- ORCID: 0000-0002-1776-2533 AD - Division of Nephrology and Hypertension and the Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas. FAU - Cohen, Aaron AU - Cohen A AD - Department of Epidemiology and Biostatistics, Indiana University School of Public Health, Bloomington, Indiana. FAU - Torres, Vicente E AU - Torres VE AD - Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota. FAU - Chebib, Fouad T AU - Chebib FT AUID- ORCID: 0000-0002-3949-5720 AD - Division of Nephrology, Mayo Clinic, Jacksonville, Florida. FAU - Landsittel, Douglas P AU - Landsittel DP AD - Department of Epidemiology and Biostatistics, Indiana University School of Public Health, Bloomington, Indiana. AD - Department of Biostatistics, University at Buffalo, The State University of New York, New York, New York. FAU - Chapman, Arlene B AU - Chapman AB AD - Division of Nephrology, University of Chicago School of Medicine, Chicago, Illinois. FAU - Mrug, Michal AU - Mrug M AD - Division of Nephrology, University of Alabama and the Department of Veterans Affairs Medical Center, Birmingham, Alabama. FAU - Harris, Peter C AU - Harris PC AUID- ORCID: 0000-0002-5304-6593 AD - Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota. FAU - Rahbari-Oskoui, Frederic F AU - Rahbari-Oskoui FF AD - Department of Internal Medicine, Emory University School of Medicine, Atlanta, Georgia. FAU - Ables, Erin AU - Ables E AUID- ORCID: 0000-0001-8617-6768 AD - Department of Epidemiology and Biostatistics, Indiana University School of Public Health, Bloomington, Indiana. FAU - Parker, Chelsie AU - Parker C AUID- ORCID: 0000-0001-5262-9693 AD - Department of Epidemiology and Biostatistics, Indiana University School of Public Health, Bloomington, Indiana. FAU - Munairdjy Debeh, Fadi George AU - Munairdjy Debeh FG AUID- ORCID: 0009-0001-0581-1211 AD - Division of Nephrology, Mayo Clinic, Jacksonville, Florida. FAU - Chedid, Maroun AU - Chedid M AD - Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota. FAU - Elbarougy, Doaa AU - Elbarougy D AUID- ORCID: 0009-0000-6487-8312 AD - Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota. FAU - Bae, Kyongtae Ty AU - Bae KT AUID- ORCID: 0000-0002-6304-4890 AD - Department of Diagnostic Radiology, University of Hong Kong, Pok Fu Lam, Hong Kong. FAU - Bennett, William M AU - Bennett WM AD - Legacy Good Samaritan Hospital, Portland, Oregon. LA - eng GR - R01 DK113111/DK/NIDDK NIH HHS/United States GR - R01 DK142878/DK/NIDDK NIH HHS/United States GR - U54 DK126126/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Validation Study DEP - 20251203 PL - United States TA - J Am Soc Nephrol JT - Journal of the American Society of Nephrology : JASN JID - 9013836 SB - IM CIN - doi: 10.1681/ASN.0000001074 MH - Humans MH - *Polycystic Kidney, Autosomal Dominant/complications/genetics MH - Female MH - Disease Progression MH - Middle Aged MH - Male MH - Adult MH - Glomerular Filtration Rate MH - Prognosis MH - Adolescent MH - *Renal Insufficiency/etiology MH - Young Adult MH - Proportional Hazards Models MH - Multivariate Analysis MH - Prediction Algorithms PMC - PMC13143440 OTO - NOTNLM OT - CKD nondialysis OT - epidemiology and outcomes OT - polycystic kidney disease OT - prediction modeling COIS- Disclosure forms, as provided by each author, are available with the online version of the article at http://links.lww.com/JSN/F561. EDAT- 2026/01/21 12:58 MHDA- 2026/05/01 12:37 PMCR- 2026/05/01 CRDT- 2026/01/21 10:33 PHST- 2025/04/02 00:00 [received] PHST- 2025/11/25 00:00 [accepted] PHST- 2026/05/01 12:37 [medline] PHST- 2026/01/21 12:58 [pubmed] PHST- 2026/01/21 10:33 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - 00001751-202605000-00012 [pii] AID - JASN-2025-000431 [pii] AID - 10.1681/ASN.0000000950 [doi] PST - ppublish SO - J Am Soc Nephrol. 2026 May 1;37(5):1010-1021. doi: 10.1681/ASN.0000000950. Epub 2025 Dec 3. PMID- 41562757 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260121 LR - 20260328 IS - 2411-5142 (Electronic) IS - 2411-5142 (Linking) VI - 11 IP - 1 DP - 2026 Jan 18 TI - The Health and Physical Education Curriculum: Does It Address Muscular Fitness? LID - 10.3390/jfmk11010040 [doi] LID - 40 AB - Background: The World Health Organization and the Australian physical activity guidelines, in line with contemporary research, recommend regular muscle-strengthening activities for optimal muscular fitness in children and adolescents. However, the extent to which muscle-strengthening or muscular fitness receives curricular emphasis is unknown in Australia. Objectives: To examine to what extent the Australian Health and Physical Education Curriculum, Foundation to Year 10 (AHPEC; F-10) addresses and/or promotes muscular fitness. Methods: This study involved a mixed-methods content analysis of the AHPEC F-10 using: (i) conceptual analysis to identify muscular fitness-related terms; and (ii) relational analysis to examine alignment between muscular fitness content and curriculum rationale/aims. A search of national and international physical activity guidelines and school-based muscular fitness intervention literature generated a keyword set to guide abstraction from the AHPEC. Curriculum aim, rationale, level descriptions, achievement standards and content were coded to determine the extent to which muscular fitness was embedded. Intercoder reliability was established via consensus meetings. Muscular fitness content coverage was quantified as the proportion of directly aligned muscular fitness relevant content points per stage and aggregated primary (F-6), secondary (7-10), and F-10 scores. Results: A review of 32 national and one international physical activity guidelines identified 88 muscular fitness activities in total, with some activities appearing in multiple guidelines; 53.1% of national guidelines did not provide explicit muscular fitness examples, and where examples existed, they emphasised accessible modes (e.g., climbing, bodyweight tasks, jumping, and lifting). Additionally, analysis of school-based muscular fitness intervention literature identified 22 distinct muscular fitness activities to guide abstraction. Muscular fitness was absent in the AHPEC rationale and aims, was largely inferred in primary years level description and achievement standards and became more explicit in secondary achievement standards. Direct alignment of content with muscular fitness was non-existent or low across stages of learning (Foundation = 0%, Stage 1 = 0%, Stage 2 = 6.1%, Stage 3 = 9.1%, Stage 4 = 8.6%, Stage 5 = 8.8%). Overall, muscular fitness content coverage averaged 3.8% in primary, 8.7% in secondary, and 5.4% across F-10. Conclusions: The AHPEC treats muscular fitness as a low priority in primary schooling and a minor content area in secondary, yielding developmental messaging that is less aligned with contemporary evidence and physical activity guidelines. FAU - Sortwell, Andrew AU - Sortwell A AUID- ORCID: 0000-0001-9987-5939 AD - School of Education, The University of Notre Dame Australia, Sydney 2007, Australia. AD - School of Health Sciences, The University of Notre Dame Australia, Fremantle 6160, Australia. AD - Research Centre in Sports Sciences, Health Sciences and Human Development (CIDESD), University of Beira Interior, 6201-001 Covilha, Portugal. FAU - Ramirez-Campillo, Rodrigo AU - Ramirez-Campillo R AUID- ORCID: 0000-0003-2035-3279 AD - Exercise and Rehabilitation Sciences Institute, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7591538, Chile. AD - Sport Sciences and Human Performance Laboratories, Instituto de Alta Investigacion, Universidad de Tarapaca, Arica 1010069, Chile. AD - Department of Physical Activity Sciences, Universidad de Los Lagos, Santiago 8320000, Chile. FAU - Granacher, Urs AU - Granacher U AUID- ORCID: 0000-0002-7095-813X AD - Department of Sport and Sport Science, Exercise and Human Movement Science, University of Freiburg, 79102 Freiburg, Germany. FAU - Joyce, Christopher AU - Joyce C AUID- ORCID: 0000-0003-0990-0876 AD - School of Health Sciences, The University of Notre Dame Australia, Fremantle 6160, Australia. FAU - Forte, Pedro AU - Forte P AUID- ORCID: 0000-0003-0184-6780 AD - Department of Sports, Higher Institute of Educational Sciences of the Douro, 4560-708 Penafiel, Portugal. AD - Department of Sports Sciences, Instituto Politecnico de Braganca, 5300-253 Braganca, Portugal. AD - Research Centre for Active Living and Wellbeing (Livewell), Instituto Politecnico de Braganca, 5300-253 Braganca, Portugal. FAU - Marinho, Daniel A AU - Marinho DA AUID- ORCID: 0000-0003-2351-3047 AD - Research Centre in Sports Sciences, Health Sciences and Human Development (CIDESD), University of Beira Interior, 6201-001 Covilha, Portugal. AD - Department of Sports Sciences, University of Beira Interior, 6201-001 Covilha, Portugal. FAU - Ferraz, Ricardo AU - Ferraz R AUID- ORCID: 0000-0002-7530-512X AD - Research Centre in Sports Sciences, Health Sciences and Human Development (CIDESD), University of Beira Interior, 6201-001 Covilha, Portugal. AD - Department of Sports Sciences, University of Beira Interior, 6201-001 Covilha, Portugal. FAU - Trimble, Kevin AU - Trimble K AUID- ORCID: 0000-0001-9748-8185 AD - School of Education, The University of Notre Dame Australia, Sydney 2007, Australia. LA - eng PT - Journal Article DEP - 20260118 PL - Switzerland TA - J Funct Morphol Kinesiol JT - Journal of functional morphology and kinesiology JID - 101712257 PMC - PMC12821546 OTO - NOTNLM OT - adolescent health OT - child health OT - muscle strength OT - physical education OT - resistance training COIS- The authors declare no conflicts of interest. EDAT- 2026/01/21 13:00 MHDA- 2026/01/21 13:01 PMCR- 2026/01/18 CRDT- 2026/01/21 09:25 PHST- 2025/11/14 00:00 [received] PHST- 2025/12/20 00:00 [revised] PHST- 2025/12/23 00:00 [accepted] PHST- 2026/01/21 13:01 [medline] PHST- 2026/01/21 13:00 [pubmed] PHST- 2026/01/21 09:25 [entrez] PHST- 2026/01/18 00:00 [pmc-release] AID - jfmk11010040 [pii] AID - jfmk-11-00040 [pii] AID - 10.3390/jfmk11010040 [doi] PST - epublish SO - J Funct Morphol Kinesiol. 2026 Jan 18;11(1):40. doi: 10.3390/jfmk11010040. PMID- 41560028 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260630 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 3 DP - 2026 Jan 16 TI - Prevalence of obesity and its relationship with lifestyle patterns among adults in Al-Baha, Saudi Arabia: A cross-sectional study. PG - e47038 LID - 10.1097/MD.0000000000047038 [doi] LID - e47038 AB - Obesity, characterized by excessive body fat accumulation, is a significant global health problem and is increasingly prevalent in Saudi Arabia, largely due to lifestyle patterns and sociodemographic factors. This study aims to determine the prevalence of obesity and its association with lifestyle factors among adults in the Al-Baha region of Saudi Arabia. A cross-sectional study was conducted among 1008 adults aged >/= 18 years in Al-Baha. Participants completed a validated, self-administered online questionnaire covering demographics, lifestyle behaviors, and health status. body mass index was calculated from self-reported height and weight. Lifestyle quality was scored and categorized. Data were analyzed using SPSS v26 with descriptive statistics and chi-square tests. Of the 1008 participants, 651 (64.6%) were males and 357 (35.4%) were females. Notably, obesity prevalence was higher among females (97, 27.2%) than males (92, 14.1%). The highest rate occurred in the 45 to 54-year-old age group (60, 35.7%). Obesity was observed in 119 (19.2%) university graduates and 10 (12.6%) postgraduates. Married participants (143, 22.7%) had a higher obesity rate than singles (40, 11.4%). A total of 114 (11.3%) were sedentary, and 54 (5.4%) consumed fast food daily. Most participants (740, 73.4%) had a fair lifestyle score, while only 11 (1.1%) reported excellent habits. Obesity was significantly associated with gender, age, marital status, education, occupation, and lifestyle score (P < .05). Obesity is highly prevalent in Al-Baha, particularly among women and middle-aged adults. The findings underscore the urgent need for targeted local programs promoting physical activity, healthier diets, and lifestyle education. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Agwa, Ramy H AU - Agwa RH AUID- ORCID: 0000-0003-3207-7486 AD - Department of Internal Medicine, Faculty of Medicine, Al-Baha University, Al-Baha, Saudi Arabia. AD - Hepatology and Gastroenterology Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt. FAU - Alkully, Turki H AU - Alkully TH AUID- ORCID: 0009-0009-7291-3216 AD - Department of Internal Medicine, Faculty of Medicine, Al-Baha University, Al-Baha, Saudi Arabia. FAU - Alghamdi, Twfiq A AU - Alghamdi TA AUID- ORCID: 0009-0009-5082-2305 AD - Al-Baha University, Al-Baha, Saudi Arabia. FAU - Alghamdi, Rami F AU - Alghamdi RF AD - Al-Baha University, Al-Baha, Saudi Arabia. FAU - Alzahrani, Ayman M AU - Alzahrani AM AD - Al-Baha University, Al-Baha, Saudi Arabia. FAU - Alghamdi, Waleed S AU - Alghamdi WS AD - Al-Baha University, Al-Baha, Saudi Arabia. FAU - Alomari, Abdulaziz M AU - Alomari AM AD - Al-Baha University, Al-Baha, Saudi Arabia. FAU - Alghamdi, Adel A AU - Alghamdi AA AD - Al-Baha University, Al-Baha, Saudi Arabia. FAU - Alghamdi, Abdulhakeem A AU - Alghamdi AA AD - Al-Baha University, Al-Baha, Saudi Arabia. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Male MH - Cross-Sectional Studies MH - Middle Aged MH - *Obesity/epidemiology MH - *Life Style MH - Prevalence MH - Female MH - Adult MH - Body Mass Index MH - Surveys and Questionnaires MH - Young Adult MH - Exercise MH - Adolescent MH - Aged PMC - PMC12826265 OTO - NOTNLM OT - Saudi Arabia OT - body mass index OT - lifestyle behaviors OT - obesity OT - public health COIS- The authors have no funding and conflicts of interest to disclose. EDAT- 2026/01/21 06:31 MHDA- 2026/01/21 06:32 PMCR- 2026/01/16 CRDT- 2026/01/21 01:03 PHST- 2025/09/07 00:00 [received] PHST- 2025/12/01 00:00 [accepted] PHST- 2026/01/21 06:32 [medline] PHST- 2026/01/21 06:31 [pubmed] PHST- 2026/01/21 01:03 [entrez] PHST- 2026/01/16 00:00 [pmc-release] AID - 00005792-202601160-00058 [pii] AID - MD-D-25-11718 [pii] AID - 10.1097/MD.0000000000047038 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Jan 16;105(3):e47038. doi: 10.1097/MD.0000000000047038. PMID- 41559179 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260627 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jan 21 TI - Knowledge of cardiovascular diseases among university students in Egypt. PG - 2637 LID - 10.1038/s41598-025-34137-6 [doi] LID - 2637 AB - Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Promoting early awareness and understanding of modifiable risk factors among young people is crucial for prevention. Yet, little is known about the level of awareness among university students in Egypt. This study aimed to evaluate university students' knowledge of cardiovascular diseases (CVDs) and their associated risk factors, with a focus on general awareness, scientific understanding, and behavioral responses related to cardiovascular health. A cross-sectional analytical study was carried out among 300 university students using a pre-validated English questionnaire administered through Google forms. Participants were recruited from seven faculties at Pharos University. The questionnaire evaluated students' knowledge of CVD risk factors and their overall awareness of cardiovascular conditions. The study revealed significantly higher knowledge scores among female participants (15.3 +/- 2.6) compared to males (13.8 +/- 4.0), (p = 0.007). The Faculty of Dentistry had the highest mean knowledge score (15.6 +/- 3.1), with a significant decline in knowledge observed among students from applied sciences and engineering/arts (p = 0.04 and 0.002, respectively). While no significant differences were found between dentistry, pharmacy, or physical education students. Higher academic grades generally had better CVD knowledge compared to first-year students (12.6 +/- 3.7), (p = 0.04). Furthermore, high awareness was noted in several areas, including the role of blood pressure control (87.6%), physical activity (85.1%), obesity (85.6%), smoking (90%), and aging (89.6%) in CVD risk. Moderate awareness was observed for family history (75.1%), blood sugar control (70.1%), and myocardial oxygen supply (70.6%). However, low awareness was noted regarding the role of HDL cholesterol (45.8%) and the effect of fatty foods on cholesterol (23.9%). Although university students showed a generally good awareness of major cardiovascular risk factors, notable knowledge gaps persisted-especially regarding dietary fats and cholesterol types. These results highlight the importance of implementing targeted educational programs to improve cardiovascular health awareness among young adults in Egypt. FAU - Adel, Maha Ibrahim AU - Adel MI AD - Dental Public Health and Preventive Dentistry Department, Faculty of Dentistry, Pharos University in Alexandria, Alexandria, Egypt. FAU - Hall, Mohamed Ashraf AU - Hall MA AUID- ORCID: 0000-0001-9452-4232 AD - Alexandria Dental Research Center, Ministry of Health and Population, Alexandria, Egypt. FAU - Karawia, Inas AU - Karawia I AUID- ORCID: 0009-0000-8465-5685 AD - Dental Public Health and Preventive Dentistry Department, Faculty of Dentistry, Pharos University in Alexandria, Alexandria, Egypt. inas.karawia@pua.edu.eg. LA - eng PT - Journal Article DEP - 20260121 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - *Cardiovascular Diseases/epidemiology MH - Egypt/epidemiology MH - *Students/psychology MH - Universities MH - *Health Knowledge, Attitudes, Practice MH - Male MH - Young Adult MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - Risk Factors MH - Adult MH - Adolescent PMC - PMC12824341 OTO - NOTNLM OT - Awareness OT - Cardiovascular diseases OT - Egypt OT - Knowledge OT - Students COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: This research was approved by the Research Ethics Committee at Pharos University under registration no. (UREAC-02-3-376). All methods were carried out in agreement with the Helsinki Declaration, before the beginning of the study. Written informed consent was obtained from all participants. They were informed that participation in the questionnaire was anonymous and completely voluntary. Secure data storage and restricted access to personal information to maintain confidentiality and ensure participant privacy. EDAT- 2026/01/21 01:48 MHDA- 2026/06/27 16:09 PMCR- 2026/01/21 CRDT- 2026/01/20 23:26 PHST- 2025/08/12 00:00 [received] PHST- 2025/12/24 00:00 [accepted] PHST- 2026/06/27 16:09 [medline] PHST- 2026/01/21 01:48 [pubmed] PHST- 2026/01/20 23:26 [entrez] PHST- 2026/01/21 00:00 [pmc-release] AID - 10.1038/s41598-025-34137-6 [pii] AID - 34137 [pii] AID - 10.1038/s41598-025-34137-6 [doi] PST - epublish SO - Sci Rep. 2026 Jan 21;16(1):2637. doi: 10.1038/s41598-025-34137-6. PMID- 41556732 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260630 IS - 1827-1928 (Electronic) IS - 0022-4707 (Linking) VI - 66 IP - 3 DP - 2026 Mar TI - Further evidence on the psychometric properties and convergent validity of the expanded exercise addiction inventory (EAI-3) in recreational exercisers. PG - 464-474 LID - 10.23736/S0022-4707.25.17274-5 [doi] AB - BACKGROUND: Exercise addiction (EA) is a maladaptive pattern of excessive exercise despite negative physical, psychological, and social consequences. The Expanded Exercise Addiction Inventory (EAI-3) was developed to improve the assessment of EA. This study validates the Hebrew version of the EAI-3 in Israel, where physical fitness is closely tied to national identity and military culture. METHODS: A sample of 367 recreational exercisers (140 men, 227 women; aged 18-45) completed the Hebrew EAI-3, the Exercise Dependence Scale-Revised (EDS-R), and the Eating Attitudes Test (EAT-26). Confirmatory factor analysis (CFA) and measurement invariance testing were conducted. RESULTS: CFA supported a two-factor structure (Health Relevance and Addiction Tendency). A 7-item version demonstrated superior psychometric properties compared to the original 8-item scale. Internal consistency was moderate (alpha=0.61), but McDonald's omega (omega=0.68) indicated better reliability. The EAI-3 showed strong convergent validity with the EDS-R (r=0.45) and concurrent validity with the EAT-26 (r=0.24). The 7-item version achieved scalar invariance across gender, allowing for meaningful comparisons. CONCLUSIONS: The Hebrew EAI-3 is a valid tool for assessing risk of exercise addiction in Israeli exercisers. The 7-item version is recommended for clinical and research applications, particularly for gender-based analyses. FAU - Lev Arey, Dalit AU - Lev Arey D AD - Department of Psychology, Academic College of Tel Aviv-Yaffo, Tel Aviv, Israel - dalitlevarey@gmail.com. FAU - Levental, Orr AU - Levental O AD - Department of Physical Education, Tel Hai Academic College, Upper Galilee, Israel. FAU - Yaffe, Yosi AU - Yaffe Y AD - Department of Physical Education, Tel Hai Academic College, Upper Galilee, Israel. LA - eng PT - Journal Article PT - Validation Study DEP - 20260120 PL - Italy TA - J Sports Med Phys Fitness JT - The Journal of sports medicine and physical fitness JID - 0376337 SB - IM MH - Humans MH - Psychometrics MH - *Behavior, Addictive/diagnosis/psychology MH - Male MH - Female MH - Reproducibility of Results MH - Adult MH - Israel MH - Adolescent MH - Young Adult MH - *Exercise/psychology MH - Middle Aged MH - Surveys and Questionnaires MH - Factor Analysis, Statistical EDAT- 2026/01/20 14:03 MHDA- 2026/03/06 08:59 CRDT- 2026/01/20 09:25 PHST- 2026/03/06 08:59 [medline] PHST- 2026/01/20 14:03 [pubmed] PHST- 2026/01/20 09:25 [entrez] AID - S0022-4707.25.17274-5 [pii] AID - 10.23736/S0022-4707.25.17274-5 [doi] PST - ppublish SO - J Sports Med Phys Fitness. 2026 Mar;66(3):464-474. doi: 10.23736/S0022-4707.25.17274-5. Epub 2026 Jan 20. PMID- 41556486 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260630 IS - 2326-3660 (Electronic) IS - 0091-3847 (Linking) VI - 54 IP - 3 DP - 2026 Jun TI - Sex-based differences in pediatric lateral ankle avulsion fractures: males are more likely to sustain avulsion fractures. PG - 207-213 LID - 10.1080/00913847.2026.2620362 [doi] AB - OBJECTIVE: To assess sex-based differences in the frequency and characteristics of pediatric lateral ankle avulsion fractures. METHODS: This prospective observational cohort study (Level II) was conducted at a tertiary sports medicine clinic between July 2022 and March 2025. This study included a total of 132 patients with 133 injuries aged 5-12 years presenting within 30 days of a first-time lateral ankle injury (67.4% female and 32.6% male). Injuries were categorized as avulsion or non-avulsion using ultrasound as the reference standard. Demographics, injury type and mechanism, sport type, and validated patient-reported measures were analyzed by sex using chi-squared and Mann-Whitney U tests. RESULTS: Males were found to be significantly more likely to sustain lateral ankle avulsion fractures than their female counterparts (50.0% vs. 24.1%, p < 0.01). There were no statistically significant differences between the avulsion and non-avulsion groups for age, race, ethnicity, BMI, or days to presentation. Sport during injury did vary by sex (p = 0.02), but the cause of injury did not. Pain, mobility, anxiety, and Pedi-FABS scores did not vary between sexes at presentation, regardless of their avulsion status. CONCLUSIONS: Our study demonstrated that males with lateral ankle injuries were more likely to sustain avulsion fractures than females in this pediatric population. Despite these differences in injury type, both sexes reported similar levels of function, anxiety, pain, and activity at initial presentation. Understanding early sex-based differences in lateral ankle fracture patterns may inform diagnostic evaluation and management in pediatric patients. FAU - Reese, Lauren T AU - Reese LT AD - School of Medicine, University of Texas Southwestern, Dallas, TX, USA. FAU - Schultz, Cassidy M AU - Schultz CM AD - Department of Sports Medicine, Scottish Rite for Children, Frisco, TX, USA. FAU - Van Pelt, Robert L AU - Van Pelt RL AD - Department of Sports Medicine, Scottish Rite for Children, Frisco, TX, USA. FAU - Lampe, Katherine AU - Lampe K AD - Department of Sports Medicine, Scottish Rite for Children, Frisco, TX, USA. FAU - Chung, Jane S AU - Chung JS AD - School of Medicine, University of Texas Southwestern, Dallas, TX, USA. AD - Department of Sports Medicine, Scottish Rite for Children, Frisco, TX, USA. FAU - Miller, Shane M AU - Miller SM AD - School of Medicine, University of Texas Southwestern, Dallas, TX, USA. AD - Department of Sports Medicine, Scottish Rite for Children, Frisco, TX, USA. FAU - Wyatt, Charles W AU - Wyatt CW AD - School of Medicine, University of Texas Southwestern, Dallas, TX, USA. AD - Department of Sports Medicine, Scottish Rite for Children, Frisco, TX, USA. FAU - Ellis, Henry B AU - Ellis HB AD - School of Medicine, University of Texas Southwestern, Dallas, TX, USA. AD - Department of Sports Medicine, Scottish Rite for Children, Frisco, TX, USA. FAU - Wilson, Philip L AU - Wilson PL AD - School of Medicine, University of Texas Southwestern, Dallas, TX, USA. AD - Department of Sports Medicine, Scottish Rite for Children, Frisco, TX, USA. FAU - Jones, Jacob C AU - Jones JC AD - School of Medicine, University of Texas Southwestern, Dallas, TX, USA. AD - Department of Sports Medicine, Scottish Rite for Children, Frisco, TX, USA. LA - eng PT - Journal Article PT - Observational Study DEP - 20260127 PL - England TA - Phys Sportsmed JT - The Physician and sportsmedicine JID - 0427461 SB - IM MH - Humans MH - Male MH - Child MH - Prospective Studies MH - Child, Preschool MH - Female MH - *Fractures, Avulsion/epidemiology/diagnostic imaging MH - Sex Factors MH - *Ankle Fractures/epidemiology/diagnostic imaging MH - *Ankle Injuries/epidemiology MH - Ultrasonography OTO - NOTNLM OT - Diagnostic imaging OT - injury epidemiology OT - ligamentous injuries OT - sports medicine OT - ultrasonography EDAT- 2026/01/20 14:03 MHDA- 2026/06/01 12:38 CRDT- 2026/01/20 07:43 PHST- 2026/06/01 12:38 [medline] PHST- 2026/01/20 14:03 [pubmed] PHST- 2026/01/20 07:43 [entrez] AID - 10.1080/00913847.2026.2620362 [doi] PST - ppublish SO - Phys Sportsmed. 2026 Jun;54(3):207-213. doi: 10.1080/00913847.2026.2620362. Epub 2026 Jan 27. PMID- 41555649 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260630 IS - 1365-2214 (Electronic) IS - 0305-1862 (Print) IS - 0305-1862 (Linking) VI - 52 IP - 1 DP - 2026 Jan TI - Screen Time, Fatigue, Obesity and Physical Inactivity: Health Correlates of Problematic Smartphone Use in Adolescents. PG - e70237 LID - 10.1111/cch.70237 [doi] LID - e70237 AB - OBJECTIVE: This study aimed to determine the prevalence of problematic smartphone use (PSU) among Tunisian adolescents, examine variations by sex and age and investigate associations with physical activity, fatigue and obesity while assessing the potential protective role of sports participation. METHODS: A cross-sectional study of 960 adolescents (53% female), aged 14-16 years utilized validated Arabic instruments including the Smartphone Addiction Scale-Short Version (SAS-SV), International Physical Activity Questionnaire (IPAQ-SF) and Fatigue Assessment Scale (FAS). Anthropometric measurements followed WHO protocols, and objective screen time data were collected from device tracking features. Statistical analyses included Mann-Whitney U tests, chi-square tests, Spearman's correlations and logistic regression models with sex stratification, all adjusted for multiple comparisons using Benjamini-Hochberg correction. RESULTS: PSU prevalence was 15.7%, with significantly higher rates in males (p < 0.001) and during mid-adolescence (p < 0.001). Adolescents with PSU showed substantially higher screen time (435 vs. 155 min/day, p < 0.001), reduced vigorous physical activity (0 vs. 480 MET-min/week, p < 0.001), increased obesity (12.6% vs. 0.7%, p < 0.001) and more severe fatigue (50.3% vs. 5.8%, p < 0.001). Sports participation demonstrated protective effects against PSU (OR = 0.4-0.6), with significantly stronger effects in females (interaction p = 0.03). CONCLUSION: PSU represents a significant public health concern among Tunisian adolescents, with a prevalence of 15.7% that is higher in males and mid-adolescents. It is associated with excessive screen time, inactivity, elevated BMI and fatigue, whereas sports participation offers a protective effect, particularly among girls. CI - (c) 2026 The Author(s). Child: Care, Health and Development published by John Wiley & Sons Ltd. FAU - Yaakoubi, Mohamed AU - Yaakoubi M AUID- ORCID: 0009-0003-5187-236X AD - High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia. AD - Research Unit: Physical Activity, Sport and Health, UR18JS01, at the National Observatory of Sport, Tunis, Tunisia. FAU - Ghorbel, Ahmed AU - Ghorbel A AUID- ORCID: 0009-0004-6890-9867 AD - High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia. AD - Research Unit: Physical Activity, Sport and Health, UR18JS01, at the National Observatory of Sport, Tunis, Tunisia. FAU - Abdelkafi, Hiba AU - Abdelkafi H AUID- ORCID: 0000-0002-9869-456X AD - The High Institute of Applied Studies in Humanities of Mahdia, Department of Education Sciences, University of Monastir, Mahdia, Tunisia. FAU - Masmoudi, Liwa AU - Masmoudi L AUID- ORCID: 0000-0002-9628-1585 AD - Research Unit: Physical Activity, Sport and Health, UR18JS01, at the National Observatory of Sport, Tunis, Tunisia. AD - High Institute of Sports and Physical Education of Sfax, University of Sfax, Sfax, Tunisia. FAU - Gharbi, Adnene AU - Gharbi A AUID- ORCID: 0000-0001-9971-1993 AD - Research Unit: Physical Activity, Sport and Health, UR18JS01, at the National Observatory of Sport, Tunis, Tunisia. AD - High Institute of Sports and Physical Education of Sfax, University of Sfax, Sfax, Tunisia. FAU - Trabelsi, Omar AU - Trabelsi O AUID- ORCID: 0009-0008-2568-3000 AD - High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia. AD - Research Unit: Physical Activity, Sport and Health, UR18JS01, at the National Observatory of Sport, Tunis, Tunisia. AD - The High Institute of Applied Studies in Humanities of Mahdia, Department of Education Sciences, University of Monastir, Mahdia, Tunisia. LA - eng PT - Journal Article PL - England TA - Child Care Health Dev JT - Child: care, health and development JID - 7602632 SB - IM MH - Humans MH - Adolescent MH - Female MH - *Screen Time MH - Cross-Sectional Studies MH - Male MH - *Sedentary Behavior MH - *Smartphone/statistics & numerical data MH - *Fatigue/epidemiology/psychology MH - *Exercise MH - Tunisia/epidemiology MH - Adolescent Behavior/psychology MH - Prevalence MH - *Behavior, Addictive/epidemiology MH - *Obesity/epidemiology MH - Sex Factors MH - *Internet Addiction Disorder/epidemiology PMC - PMC12816945 OTO - NOTNLM OT - adolescence OT - fatigue OT - gender differences OT - overweight OT - physical activity OT - sedentary behaviour OT - smartphone addiction COIS- The authors declare no potential conflicts of interest. EDAT- 2026/01/20 07:44 MHDA- 2026/01/20 07:45 PMCR- 2026/01/20 CRDT- 2026/01/20 01:42 PHST- 2025/12/24 00:00 [revised] PHST- 2025/08/22 00:00 [received] PHST- 2026/01/05 00:00 [accepted] PHST- 2026/01/20 07:45 [medline] PHST- 2026/01/20 07:44 [pubmed] PHST- 2026/01/20 01:42 [entrez] PHST- 2026/01/20 00:00 [pmc-release] AID - CCH70237 [pii] AID - 10.1111/cch.70237 [doi] PST - ppublish SO - Child Care Health Dev. 2026 Jan;52(1):e70237. doi: 10.1111/cch.70237. PMID- 41555079 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260813 IS - 1433-9285 (Electronic) IS - 0933-7954 (Print) IS - 0933-7954 (Linking) VI - 61 IP - 5 DP - 2026 May TI - Reducing social disparities in child emotional and behavioral problems by hypothetical physical activity and screen time interventions. PG - 819-828 LID - 10.1007/s00127-025-03036-6 [doi] AB - PURPOSE: To estimate how social disparities in child psychiatric symptoms might change following hypothetical interventions targeting sports, outdoor play, and screen time at age 10. METHODS: We used data from 9,778 children of the Generation R Study, a prospective population-based cohort in Rotterdam, the Netherlands. Social inequality variables included sex, maternal education, and migration background. Primary caregivers filled out the validated Child Behavior Checklist to report on children's internalizing and externalizing symptoms at the age of 13. The hypothetical interventions (i.e., outdoor play, sports participation, and screen time) were parent-reported at age 10. We used sequential G-estimation to estimate the inequality with and without the hypothetical intervention. RESULTS: Children with migration backgrounds (46.3%) and low maternal education (53.3%) were associated with relatively more internalizing and externalizing symptoms than peers, with disparities of 0.125 and 0.177 standard deviations, respectively. Girls had more internalizing symptoms (0.106 SD), while boys had more externalizing symptoms (0.154 SD). Increasing sports participation reduced disparities in internalizing symptoms linked to maternal education (beta = -0.014; 95% CI: -0.024, -0.003), while outdoor play and screen time interventions showed limited effects. None of the hypothetical interventions led to a statistically significant reduction in social disparities in externalizing symptoms. CONCLUSIONS: This study underscores the persistence of sex, cultural, and socioeconomic disparities in youth mental health. While sports participation showed a potential effect in reducing disparities in internalizing symptoms, its impact on externalizing symptoms and other interventions was negligible. Future efforts should focus on identifying more effective strategies for addressing these disparities. CI - (c) 2026. The Author(s). FAU - Rodriguez-Ayllon, Maria AU - Rodriguez-Ayllon M AUID- ORCID: 0000-0002-8267-0440 AD - Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Center, Rotterdam, 3000 CA, The Netherlands. AD - Biomedical Research Institute of Malaga (IBIMA Platform Bionand), Malaga, Spain. AD - Prevention and Health Promotion Research Network (redIAPP) & Chronicity, Primary Care and Health Promotion Research Network, (RICAPPS), ISCIII, Madrid, Spain. FAU - Jansen, Pauline W AU - Jansen PW AUID- ORCID: 0000-0001-7747-5803 AD - Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Center, Rotterdam, 3000 CA, The Netherlands. p.w.jansen@erasmusmc.nl. AD - Department of Psychology, Education and Child Studies, Erasmus School of Social and Behavioural Sciences, Erasmus University, Rotterdam, The Netherlands. p.w.jansen@erasmusmc.nl. FAU - Labrecque, Jeremy A AU - Labrecque JA AUID- ORCID: 0000-0002-1028-2158 AD - Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. FAU - Enthoven, Clair A AU - Enthoven CA AUID- ORCID: 0000-0003-0812-8765 AD - Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Center, Rotterdam, 3000 CA, The Netherlands. AD - The Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands. LA - eng GR - CD23/00096/Instituto de Salud Carlos III/ PT - Journal Article DEP - 20260119 PL - Germany TA - Soc Psychiatry Psychiatr Epidemiol JT - Social psychiatry and psychiatric epidemiology JID - 8804358 SB - IM MH - Humans MH - Female MH - Male MH - Netherlands/epidemiology MH - Child MH - *Screen Time MH - *Exercise/psychology MH - Prospective Studies MH - Socioeconomic Disparities in Health MH - *Child Behavior/psychology MH - Sports/psychology MH - Adolescent MH - *Child Behavior Disorders/epidemiology/prevention & control MH - Socioeconomic Factors PMC - PMC13156153 OTO - NOTNLM OT - Childhood OT - Exercise OT - Mental health OT - Social disparities OT - Sports OT - Youth COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/01/20 00:37 MHDA- 2026/05/08 12:38 PMCR- 2026/01/19 CRDT- 2026/01/19 23:31 PHST- 2025/07/10 00:00 [received] PHST- 2025/12/23 00:00 [accepted] PHST- 2026/05/08 12:38 [medline] PHST- 2026/01/20 00:37 [pubmed] PHST- 2026/01/19 23:31 [entrez] PHST- 2026/01/19 00:00 [pmc-release] AID - 10.1007/s00127-025-03036-6 [pii] AID - 3036 [pii] AID - 10.1007/s00127-025-03036-6 [doi] PST - ppublish SO - Soc Psychiatry Psychiatr Epidemiol. 2026 May;61(5):819-828. doi: 10.1007/s00127-025-03036-6. Epub 2026 Jan 19. PMID- 41554872 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260926 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jan 19 TI - Dietary exposure to N-nitrosamines and their precursors: an age-stratified assessment. PG - 4047 LID - 10.1038/s41598-025-34144-7 [doi] LID - 4047 AB - Dietary exposure to N-nitrosamines (N-NAs) may pose health concerns across all age groups, particularly in children and the elderly, due to their association with increased cancer risk. This study risk-assessed age-specific dietary intake of N-NAs and main dietary sources. N-NAs consumption was estimated from 671 questionnaires (validated Food Frequency Questionnaires) obtained from 116 children (followed-up from 6 months to 4 years) and 182 adults (aged 19 to 95 years) from northern Spain (Asturias). The content of nitrates, nitrites and N-NAs was calculated per 100 g of food for 348 items primarily using EFSA and EPIC data. Intakes were standardized by body weight and dietary sources were analysed using the FoodSources Shiny-app. The highest mean N-NAs intake, mainly of N-Nitrosodimethylamine (NDMA), was observed at 48 months and was derived from processed meats. Among adults, nitrite intake was primarily attributable to animal sources and 12 to 19% of individuals exceeded the acceptable daily intake (ADI). In children, the lowest margin of exposure (MOE) for N-NAs was found at 48 months, and MOEs below 10,000 were observed from 12 months to 95 years. Early childhood appears to be a critical window for reducing exposure to carcinogens, supporting the development of targeted public-health policies. CI - (c) 2026. The Author(s). FAU - Zapico, Aida AU - Zapico A AD - Department of Functional Biology, University of Oviedo, Oviedo, 33006, Spain. zapicoaida@uniovi.es. AD - Diet, Microbiota and Health Group, Instituto de Investigacion Sanitaria del Principado de Asturias (ISPA), Oviedo, 33011, Spain. zapicoaida@uniovi.es. FAU - Herrero-Morin, David AU - Herrero-Morin D AD - Pediatrics Service, Centro Atencion Primaria Infiesto, SESPA, Pilona, 33530, Spain. FAU - Arboleya, Silvia AU - Arboleya S AD - Diet, Microbiota and Health Group, Instituto de Investigacion Sanitaria del Principado de Asturias (ISPA), Oviedo, 33011, Spain. AD - Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lacteos de Asturias (IPLA-CSIC), Oviedo, 33011, Spain. FAU - de Los Reyes-Gavilan, Clara G AU - de Los Reyes-Gavilan CG AD - Diet, Microbiota and Health Group, Instituto de Investigacion Sanitaria del Principado de Asturias (ISPA), Oviedo, 33011, Spain. AD - Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lacteos de Asturias (IPLA-CSIC), Oviedo, 33011, Spain. FAU - Gueimonde, Miguel AU - Gueimonde M AD - Diet, Microbiota and Health Group, Instituto de Investigacion Sanitaria del Principado de Asturias (ISPA), Oviedo, 33011, Spain. AD - Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lacteos de Asturias (IPLA-CSIC), Oviedo, 33011, Spain. FAU - Gonzalez, Sonia AU - Gonzalez S AD - Department of Functional Biology, University of Oviedo, Oviedo, 33006, Spain. soniagsolares@uniovi.es. AD - Diet, Microbiota and Health Group, Instituto de Investigacion Sanitaria del Principado de Asturias (ISPA), Oviedo, 33011, Spain. soniagsolares@uniovi.es. LA - eng GR - PA- 23-BP22-034/Plan Regional de Investigacion from the Principality of Asturias/ PT - Journal Article DEP - 20260119 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Nitrosamines) RN - 0 (Nitrites) RN - 0 (Nitrates) SB - IM MH - Humans MH - *Nitrosamines/adverse effects/analysis MH - Child, Preschool MH - Adult MH - Aged MH - *Dietary Exposure/adverse effects MH - Infant MH - Middle Aged MH - Female MH - Child MH - Spain MH - Aged, 80 and over MH - Young Adult MH - Male MH - Nitrites/analysis MH - Nitrates/analysis MH - Age Factors PMC - PMC12855995 OTO - NOTNLM OT - N-nitrosamines (N-NAs) OT - Endogenous nitrosation OT - Nitrate OT - Nitrite OT - Risk assessment OT - Vulnerable populations COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: Ethical approvals were obtained by the Bioethical Committee of CSIC and from the Regional Ethics Committee for Clinical Research of the Principality of Asturias (Ref. PCIN-2015-233, 12/16, 03/02/2016 and 17/2010). Informed consent was obtained from all individual participants or their legal representatives, included in the study. EDAT- 2026/01/20 00:37 MHDA- 2026/01/30 00:54 PMCR- 2026/01/19 CRDT- 2026/01/19 23:25 PHST- 2025/07/07 00:00 [received] PHST- 2025/12/24 00:00 [accepted] PHST- 2026/01/30 00:54 [medline] PHST- 2026/01/20 00:37 [pubmed] PHST- 2026/01/19 23:25 [entrez] PHST- 2026/01/19 00:00 [pmc-release] AID - 10.1038/s41598-025-34144-7 [pii] AID - 34144 [pii] AID - 10.1038/s41598-025-34144-7 [doi] PST - epublish SO - Sci Rep. 2026 Jan 19;16(1):4047. doi: 10.1038/s41598-025-34144-7. PMID- 41551470 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Application of the Ballroom Aerobic Test protocol for assessing performance in standard-style dancesport athletes. PG - e20556 LID - 10.7717/peerj.20556 [doi] LID - e20556 AB - BACKGROUND: Although the existing field-based tests to assess functional capacity in dancesport have been developed, most of them have been applied to ballet or contemporary dancesport athletes at the individual level, while little evidence is available for dancesport couples in standard dance disciplines. Therefore, the main purpose of this study was to examine the test-retest reliability and usefulness of the progressive Ballroom Aerobic Test (BAT) protocol for assessing aerobic performance. METHODS: Thirteen standard dancesport athletes (six pairs and one individual male participant; age: 20.1 +/- 3.8 years; height: 175.0 +/- 8.2 cm; weight: 64.3 +/- 9.7 kg; males; age: 19.9 +/- 3.7 years; height: 180.0 +/- 4.7 cm; weight: 70.2 +/- 8.7 kg; body mass index: 21.5 +/- 1.8 kg/m2 training experience: 8.6 +/- 5.1 years; females; age: 20.3 +/- 4.0 years; height: 168.5 +/- 6.5 cm; weight: 57.5 +/- 5.5 kg; body mass index: 20.2 +/- 1.3 kg/m(2); training experience: 8.5 +/- 3.4 years) took part in the study. All participants were members of certified dancesport clubs who competed at national and international levels. The BAT protocol consisted of five stages, each corresponding to one of five standard dancesport disciplines (English Waltz, Slow Foxtrot, Tango, Viennese Waltz, and Quickstep). A test-retest design, with one week between trials, was used to examine the reliability measures. Ventilatory and metabolic parameters were derived from MetaMax((R)) 3B, a reliable and valid portable gas analyzer. Reliability measures included Cohen D effect size (ES), intra-class correlation coefficient (ICC), coefficient of variation (CV), typical error (TE) and smallest worthwhile change (SWC). RESULTS: No significant differences were observed between test and retest sessions (P > 0.05). ESs ranged from trivial to small (0.00-0.47) with 'very good' to 'excellent' reliability (ICC = 0.80-0.99; CV = 1.63-4.85%). The usefulness of the BAT protocol was generally rated as 'ok' to 'good' for speed (TE = 2.76; SWC = 3.20; <), absolute VO(2) (TE = 0.14; SWC = 0.15; <), respiratory exchange ratio (RER; TE = 0.02; SWC = 0.02; =), tidal volume (VT = 0.06; SWC = 0.06; =), and dead space to tidal volume ratio (VD/VT; TE = 0.01; SWC = 0.01; =). CONCLUSION: Current findings suggest that the BAT protocol is a reliable and useful tool for assessing aerobic capacity in standard-style dancesport athletes. Moreover, the BAT protocol can accurately detect meaningful individual changes, particularly for speed (3.20 bpm), absolute VO(2) (0.15 L*min(-1)), and VE (4.87 L). These results may assist athletes and strength and conditioning coaches in monitoring and tracking 'real' time changes to optimize the training process. CI - (c)2026 Despot and Plavec. FAU - Despot, Tamara AU - Despot T AD - Faculty of Kinesiology, University Zagreb, Zagreb, Croatia. AD - Dance Studio 'Dancespot', Zagreb, Croatia. FAU - Plavec, Davor AU - Plavec D AD - Facility for Medical Care 'Prima Nova', Zagreb, Croatia. AD - Medical Faculty, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia. LA - eng PT - Journal Article DEP - 20260113 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - Male MH - Reproducibility of Results MH - *Exercise Test/methods MH - Female MH - Oxygen Consumption/physiology MH - Young Adult MH - *Dancing/physiology MH - *Athletes MH - *Athletic Performance/physiology MH - Adolescent MH - Adult PMC - PMC12810390 OTO - NOTNLM OT - Aesthetic sports OT - Cardiorespiratory fitness OT - Coefficient of variation OT - Effect size OT - Smallest worthwhile change OT - The BAT protocol OT - Typical error COIS- Davor Plavec is an Academic Editor for PeerJ. Tamara Despot is employed by Dance studio 'Dancespot' and Davor Plavec is employed by Facility for medical care 'Prima Nova'. EDAT- 2026/01/19 12:51 MHDA- 2026/01/19 12:52 PMCR- 2026/01/13 CRDT- 2026/01/19 06:18 PHST- 2025/07/29 00:00 [received] PHST- 2025/11/18 00:00 [accepted] PHST- 2026/01/19 12:52 [medline] PHST- 2026/01/19 12:51 [pubmed] PHST- 2026/01/19 06:18 [entrez] PHST- 2026/01/13 00:00 [pmc-release] AID - 20556 [pii] AID - 10.7717/peerj.20556 [doi] PST - epublish SO - PeerJ. 2026 Jan 13;14:e20556. doi: 10.7717/peerj.20556. eCollection 2026. PMID- 41548363 OWN - NLM STAT- MEDLINE DCOM- 20260304 LR - 20260304 IS - 1573-2509 (Electronic) IS - 0920-9964 (Linking) VI - 289 DP - 2026 Mar TI - Prevalence and multidimensional impact of sarcopenia in schizophrenia: Associations with oxidative stress, functioning, and symptom severity. PG - 61-70 LID - S0920-9964(26)00002-2 [pii] LID - 10.1016/j.schres.2026.01.002 [doi] AB - OBJECTIVE: This study aimed to investigate the prevalence of sarcopenia in individuals with schizophrenia and examine its associations with oxidative stress, symptom severity, functioning, and quality of life. METHODS: A total of 198 schizophrenia patients aged 18-65 were assessed using the EWGSOP2 criteria for sarcopenia. Participants were classified as sarcopenic if they met criteria for probable, confirmed, or severe sarcopenia. Oxidative stress was evaluated using total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI). Clinical functioning, psychiatric symptoms, and quality of life were assessed using standardized psychometric tools. Multiple linear regression was conducted to identify predictors of oxidative stress parameters. RESULTS: Sarcopenia was identified in 66.6% of participants, with most meeting criteria for probable sarcopenia. Sarcopenic patients had significantly lower muscle mass, bone mass, basal metabolic rate, handgrip strength, and walking speed, along with poorer quality of life and functional scores. TAC positively correlated with muscle-related parameters and inversely with sarcopenia severity, while OSI showed negative correlations with physical health indicators. Sarcopenic patients also had more severe psychiatric symptoms. Regression analysis revealed that TAC was significantly predicted by BMI, the number of sarcopenia criteria met, PANSS-Total, and WHOQOL-BREF scores (R(2) = 0.10, p = .011). No significant differences were found in mean TAC, TOS, and OSI between sarcopenic and non-sarcopenic groups. CONCLUSION: Sarcopenia is highly prevalent and clinically relevant in individuals with schizophrenia, even at midlife. Routine screening and early interventions targeting physical health and oxidative stress may improve outcomes. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Sisman, Ozgu AU - Sisman O AD - Department of Psychiatry, University of Health Sciences Bursa Faculty of Medicine, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkiye. Electronic address: ozgu.sisman@sbu.edu.tr. FAU - Onen, Sinay AU - Onen S AD - Department of Psychiatry, University of Health Sciences Bursa Faculty of Medicine, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkiye. Electronic address: sinay.onen@sbu.edu.tr. LA - eng PT - Journal Article DEP - 20260117 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 SB - IM EIN - Schizophr Res. 2026 Mar;289:112. doi: 10.1016/j.schres.2026.01.017. PMID: 41611544 MH - Prevalence MH - *Sarcopenia/epidemiology/physiopathology/psychology MH - *Schizophrenia/complications/physiopathology MH - *Oxidative Stress/physiology MH - Severity of Illness Index MH - *Symptom Burden MH - Quality of Life MH - Regression Analysis MH - Cross-Sectional Studies MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged MH - Aged OTO - NOTNLM OT - Functioning OT - Oxidative stress OT - Quality of life OT - Sarcopenia OT - Schizophrenia COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/01/19 01:03 MHDA- 2026/02/15 00:31 CRDT- 2026/01/18 18:03 PHST- 2025/07/07 00:00 [received] PHST- 2025/12/18 00:00 [revised] PHST- 2026/01/06 00:00 [accepted] PHST- 2026/02/15 00:31 [medline] PHST- 2026/01/19 01:03 [pubmed] PHST- 2026/01/18 18:03 [entrez] AID - S0920-9964(26)00002-2 [pii] AID - 10.1016/j.schres.2026.01.002 [doi] PST - ppublish SO - Schizophr Res. 2026 Mar;289:61-70. doi: 10.1016/j.schres.2026.01.002. Epub 2026 Jan 17. PMID- 41548262 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260904 IS - 1878-5506 (Electronic) IS - 1389-9457 (Linking) VI - 140 DP - 2026 Apr TI - High night-to-night variability in childhood obstructive sleep apnea severity. PG - 108784 LID - S1389-9457(26)00022-5 [pii] LID - 10.1016/j.sleep.2026.108784 [doi] AB - STUDY: Overnight in-laboratory polysomnography is the gold standard test for childhood obstructive sleep apnea (OSA). Night-to-night variability is a well-documented phenomenon in adult literature but is poorly characterized in children. We evaluated the test-retest reliability of polysomnography in children with moderate-severe OSA. METHODS: This is a secondary analysis of two pediatric trials evaluating OSA therapies for children aged 4-18 years old with moderate-severe OSA. The baseline diagnostic polysomnography data were compared to repeat polysomnography data in trial. RESULTS: Twenty-seven children were included (median age 8 years, 41% females, body mass index z-score 1.4). The median inter-test interval was 48 days (range: 14-78 days). There were 7/27 children (26%) with moderate-severe OSA whose second polysomnography showed mild or no OSA. The median (interquartile range) obstructive apnea-hypopnea index on the first night was 9.4 (7.4-14.0) events/hour and 14.2 (5.4-21.6) events/hour on the second night, with poor correlation (intraclass correlation coefficient; ICC 0.27; 95% CI -0.04, 0.51; p = 0.080). There was poor correlation for the oxygen desaturation index (8.9 versus 10.9 events/hour; ICC 0.10; 95% CI -0.26, 0.53; p = 0.31), and poor correlation for hypoxic burden (31.9 versus 48.7 %min/hour; ICC 0.45; 95% CI 0.10, 0.70; p = 0.0072). CONCLUSION: Polysomnograms demonstrate poor test-retest reliability in children with moderate-severe OSA. There should be caution relying solely on a single night polysomnogram in children with moderate-severe OSA. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Xiao, Lena AU - Xiao L AD - Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada; University of Toronto, Toronto, Canada; Department of Pediatrics, British Columbia Children's Hospital, Vancouver, Canada; University of British Columbia, Vancouver, Canada. Electronic address: lena.xiao@cw.bc.ca. FAU - Terrance, Mystica AU - Terrance M AD - Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada; University of Toronto, Toronto, Canada. Electronic address: mystica.terrance@sickkids.ca. FAU - Au, Chun Ting AU - Au CT AD - Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address: jun.au@sickkids.ca. FAU - Massicotte, Colin AU - Massicotte C AD - Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada. Electronic address: colin.massicotte@sickkids.ca. FAU - Narang, Indra AU - Narang I AD - Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada; University of Toronto, Toronto, Canada; Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address: indra.narang@sickkids.ca. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260114 PL - Netherlands TA - Sleep Med JT - Sleep medicine JID - 100898759 SB - IM MH - Humans MH - *Sleep Apnea, Obstructive/diagnosis/physiopathology/therapy MH - Female MH - *Polysomnography/methods MH - Child MH - Child, Preschool MH - Severity of Illness Index MH - Male MH - Reproducibility of Results MH - Adolescent OTO - NOTNLM OT - Children OT - Obstructive sleep apnea OT - Sleep-disordered breathing COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Indra Narang reports financial support was provided by Physicians' Services Incorporated. Indra Narang reports financial support was provided by HSBC. Indra Narang reports equipment, drugs, or supplies was provided by Rematee. Indra Narang reports a relationship with Canadian Institutes of Health Research that includes: funding grants. Lena Xiao reports a relationship with The Hospital for Sick Children that includes: funding grants. Lena Xiao reports a relationship with American Thoracic Society that includes: funding grants. Lena Xiao reports a relationship with Baxter Healthcare Corporation that includes: funding grants. Lena Xiao reports a relationship with International Pediatric Sleep Association that includes: funding grants. Lena Xiao reports a relationship with Sleep Research Society Foundation that includes: funding grants. Lena Xiao reports a relationship with American College of Chest Physicians that includes: travel reimbursement. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/01/18 22:19 MHDA- 2026/02/22 05:35 CRDT- 2026/01/18 17:59 PHST- 2026/01/06 00:00 [received] PHST- 2026/01/13 00:00 [accepted] PHST- 2026/02/22 05:35 [medline] PHST- 2026/01/18 22:19 [pubmed] PHST- 2026/01/18 17:59 [entrez] AID - S1389-9457(26)00022-5 [pii] AID - 10.1016/j.sleep.2026.108784 [doi] PST - ppublish SO - Sleep Med. 2026 Apr;140:108784. doi: 10.1016/j.sleep.2026.108784. Epub 2026 Jan 14. PMID- 41547746 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jan 17 TI - The mechanism of physical exercise and adolescent short-form video app addiction: the chain mediating role of autonomous motivation and mental health literacy. PG - 569 LID - 10.1186/s12889-026-26220-y [doi] LID - 569 AB - BACKGROUND: In the digital era, excessive use of short-form video applications (Apps) can exert numerous negative effects on the physical and mental health of adolescents. Physical exercise not only benefits physical health but also enhances intrinsic motivation levels and psychological regulation abilities. Therefore, this study aims to explore the association between Physical Exercise and Short-form Video App Addiction, as well as the mediating roles of Autonomous Motivation and Mental Health Literacy in the relationship between physical exercise and short-form video app addiction. METHODS: This study employed a combination of convenience sampling and stratified sampling to conduct a cross-sectional survey among 644 junior and senior high school students. The cross-sectional nature of the data limits causal inference. Measurements included the Physical Activity Rating Scale, Autonomous Motivation Scale, Mental Health Literacy Scale, and Short-form Video App Addiction Scale. Data analysis was performed using AMOS 24, SPSS 27.0, and PROCESS 4.1 for reliability and validity assessment, descriptive statistics, correlation analysis, and mediation analysis. RESULTS: (1) Physical exercise showed a statistically significant negative correlation with adolescent short-form video app addiction; (2) Both autonomous motivation and mental health literacy independently mediated the relationship between physical exercise and adolescent short-form video App addiction; (3) Autonomous motivation and mental health literacy played a chain mediating role between physical exercise and adolescent short-form video App addiction. CONCLUSION: Physical exercise is negatively associated with adolescent short-form video app addiction, while also positively associated with autonomous motivation and mental health literacy. High levels of autonomous motivation and mental health literacy are associated with lower levels of short-form video app addiction. Based on these association patterns, we suggest that schools and families, in holistic practices promoting adolescent health development, should emphasize the integration of physical exercise, autonomous motivation development, and mental health literacy enhancement. This comprehensive health promotion approach may provide a reference for future research exploring how to promote healthy digital media use habits among adolescents. It should be noted that the directionality of the aforementioned associations and their potential intervention effects still require further validation through longitudinal tracking or experimental studies. CI - (c) 2026. The Author(s). FAU - Wu, Chengyi AU - Wu C AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Wang, Xianliang AU - Wang X AD - School of Physical Education, Shandong University, Jinan, 250061, China. wangxianliang@sdu.edu.cn. FAU - Zhang, Ying AU - Zhang Y AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Ma, Chao AU - Ma C AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Deng, Yiran AU - Deng Y AD - School of Physical Education, Shandong University, Jinan, 250061, China. LA - eng GR - 31130005442101/National Key Research and Development Program of China/ PT - Journal Article DEP - 20260117 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - *Health Literacy/statistics & numerical data MH - Adolescent MH - *Motivation MH - *Exercise/psychology MH - Female MH - Cross-Sectional Studies MH - Male MH - *Behavior, Addictive/psychology MH - *Mobile Applications/statistics & numerical data MH - *Mental Health MH - Surveys and Questionnaires PMC - PMC12895814 OTO - NOTNLM OT - Adolescents OT - Autonomous motivation OT - Mental health literacy OT - Physical exercise OT - Short-form video app addiction COIS- Declarations. Ethics approval and consent to participate: This study involved human participants and was approved by the Ethics Committee of the School of Basic Medical Sciences, Shandong University (ECSBMSSDU2024-1-141).The study was conducted in accordance with the Declaration of Helsinki. Participants and their parents or legal guardians have provided written informed consent to participate in this study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/18 00:37 MHDA- 2026/02/12 06:54 PMCR- 2026/01/17 CRDT- 2026/01/17 23:13 PHST- 2025/10/01 00:00 [received] PHST- 2026/01/05 00:00 [accepted] PHST- 2026/02/12 06:54 [medline] PHST- 2026/01/18 00:37 [pubmed] PHST- 2026/01/17 23:13 [entrez] PHST- 2026/01/17 00:00 [pmc-release] AID - 10.1186/s12889-026-26220-y [pii] AID - 26220 [pii] AID - 10.1186/s12889-026-26220-y [doi] PST - epublish SO - BMC Public Health. 2026 Jan 17;26(1):569. doi: 10.1186/s12889-026-26220-y. PMID- 41545253 OWN - NLM STAT- MEDLINE DCOM- 20260527 LR - 20260601 IS - 1873-5010 (Electronic) IS - 1569-1993 (Linking) VI - 25 IP - 3 DP - 2026 May TI - Children with cystic fibrosis have an early-life disparity in fecal short chain fatty acid concentrations. PG - 513-520 LID - S1569-1993(26)00002-0 [pii] LID - 10.1016/j.jcf.2026.01.002 [doi] AB - BACKGROUND: The depletion of short chain fatty acid (SCFA) producing bacterial species in cystic fibrosis (CF) is hypothesized to reduce overall SCFA production, contributing to the onset and persistence of gastrointestinal inflammation. METHODS: In a prospective longitudinal observational study, we compared children with CFto age-matched healthy controls (HC). Participants completed a validated food frequency questionnaire and provided fecal samples for SCFA analysis (targeted liquid chromatography-mass spectrometry (LC-MS)), fecal calprotectin, and microbial community composition (16S rRNA gene sequencing). RESULTS: 64 children with CF (cwCF) [median age (IQR) = 8.4 (4-11.9)] and 64 HC [median age (IQR) = 7.8 (3.4-13.4)] were recruited. Valerate and isobutyrate were significantly reduced and more variable over time in cwCF compared to HC. Age-associated increases in butyrate, valerate, isobutyrate and isovalerate observed in HC, were absent in CF. In CF, butyrate was positively correlated with alpha diversity (Richness = 0.3, p = 0.0005; Shannon diversity = 0.3, p = 0.0005) and inversely correlated with elevated calprotectin concentrations (-0.34, p = 0.01). CwCF had higher relative intake of fats, predominated by trans and saturated fats, alongside reduced relative intake of fibre, wholegrains and resistant starch. CONCLUSIONS: Our findings indicate that reduced microbial diversity, depletion of key SCFA-producing taxa, and limited dietary fibre intake may promote alternative, less efficient pathways of butyrate synthesis in cwCF. When butyrate is reduced, heightened inflammation is more likely. Further investigation into the physiological roles of valerate and isobutyrate is needed to understand the implications of their depletion in CF. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - van Dorst, Josie AU - van Dorst J AD - School of Clinical Medicine, Discipline of Paediatrics & Child Health, UNSW Medicine & Health, UNSW Sydney, Australia; Sydney Children's Hospital, Department of Respiratory Medicine, Randwick, Australia. Electronic address: j.vandorst@unsw.edu.au. FAU - Uthpala Pushpakumara, B L D AU - Uthpala Pushpakumara BLD AD - School of Clinical Medicine, Discipline of Paediatrics & Child Health, UNSW Medicine & Health, UNSW Sydney, Australia; Sydney Children's Hospital, Department of Respiratory Medicine, Randwick, Australia. FAU - Katz, Tamarah AU - Katz T AD - School of Clinical Medicine, Discipline of Paediatrics & Child Health, UNSW Medicine & Health, UNSW Sydney, Australia; Sydney Children's Hospital Randwick, Department of Nutrition and Dietetics, Randwick, Australia; Sydney Children's Hospital, Department of Respiratory Medicine, Randwick, Australia. FAU - Hudson, Jennifer AU - Hudson J AD - School of Clinical Medicine, Discipline of Paediatrics & Child Health, UNSW Medicine & Health, UNSW Sydney, Australia; Sydney Children's Hospital, Department of Respiratory Medicine, Randwick, Australia. FAU - Ting, Zi AU - Ting Z AD - School of Clinical Medicine, Discipline of Paediatrics & Child Health, UNSW Medicine & Health, UNSW Sydney, Australia; Sydney Children's Hospital, Department of Respiratory Medicine, Randwick, Australia. FAU - McKay, Isabelle AU - McKay I AD - School of Clinical Medicine, Discipline of Paediatrics & Child Health, UNSW Medicine & Health, UNSW Sydney, Australia; Sydney Children's Hospital, Department of Respiratory Medicine, Randwick, Australia. FAU - Tam, Rachel Y AU - Tam RY AD - School of Clinical Medicine, Discipline of Paediatrics & Child Health, UNSW Medicine & Health, UNSW Sydney, Australia; Sydney Children's Hospital, Department of Respiratory Medicine, Randwick, Australia. FAU - Chan, Christopher AU - Chan C AD - School of Clinical Medicine, Discipline of Paediatrics & Child Health, UNSW Medicine & Health, UNSW Sydney, Australia; Sydney Children's Hospital, Department of Respiratory Medicine, Randwick, Australia. FAU - Coffey, Michael AU - Coffey M AD - School of Clinical Medicine, Discipline of Paediatrics & Child Health, UNSW Medicine & Health, UNSW Sydney, Australia; Department of Gastroenterology, Sydney Children's Hospital, Randwick, Australia; Sydney Children's Hospital, Department of Respiratory Medicine, Randwick, Australia. FAU - Ooi, Chee Y AU - Ooi CY AD - School of Clinical Medicine, Discipline of Paediatrics & Child Health, UNSW Medicine & Health, UNSW Sydney, Australia; Department of Gastroenterology, Sydney Children's Hospital, Randwick, Australia; Sydney Children's Hospital, Department of Respiratory Medicine, Randwick, Australia. LA - eng PT - Journal Article PT - Observational Study DEP - 20260115 PL - Netherlands TA - J Cyst Fibros JT - Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society JID - 101128966 RN - 0 (Fatty Acids, Volatile) RN - 0 (Leukocyte L1 Antigen Complex) SB - IM MH - Humans MH - *Cystic Fibrosis/microbiology/metabolism MH - *Feces/chemistry/microbiology MH - Female MH - *Fatty Acids, Volatile/analysis/metabolism MH - Male MH - Child MH - Prospective Studies MH - Longitudinal Studies MH - Child, Preschool MH - *Gastrointestinal Microbiome MH - Leukocyte L1 Antigen Complex/analysis MH - Adolescent OTO - NOTNLM OT - Butyrate OT - Calprotectin OT - Cystic fibrosis OT - Dysbiosis OT - Inflammation OT - Isobutyrate OT - Microbiota OT - Nutrition OT - Valerate COIS- Declaration of competing interest The authors report there are no conflicts of interest related to this work. EDAT- 2026/01/17 00:36 MHDA- 2026/05/28 00:29 CRDT- 2026/01/16 21:51 PHST- 2025/09/26 00:00 [received] PHST- 2025/12/09 00:00 [revised] PHST- 2026/01/03 00:00 [accepted] PHST- 2026/05/28 00:29 [medline] PHST- 2026/01/17 00:36 [pubmed] PHST- 2026/01/16 21:51 [entrez] AID - S1569-1993(26)00002-0 [pii] AID - 10.1016/j.jcf.2026.01.002 [doi] PST - ppublish SO - J Cyst Fibros. 2026 May;25(3):513-520. doi: 10.1016/j.jcf.2026.01.002. Epub 2026 Jan 15. PMID- 41544878 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260707 IS - 1878-5476 (Electronic) IS - 1469-0292 (Print) IS - 1878-5476 (Linking) VI - 83 DP - 2026 Mar TI - The Physical Activity Relatedness Satisfaction Scale: Assessing relatedness in those who prefer to be active alone and with others. PG - 103068 LID - S1469-0292(26)00008-7 [pii] LID - 10.1016/j.psychsport.2026.103068 [doi] AB - Relatedness, or the extent to which individuals feel connected to others, is one of three basic psychological needs postulated by self-determination theory (SDT). In physical activity contexts, the extent to which relatedness satisfaction is important for maintaining physical activity is unclear, and measurement challenges have hindered progress in the field. Specifically, many individuals prefer solitary physical activity, yet existing instruments assessing relatedness in physical activity are predominantly designed for group-based exercise settings. The purpose of this study was to develop and examine the psychometric properties of a new measure of relatedness for physical activity contexts, the Physical Activity Relatedness Satisfaction Scale (PARSS). Participants (N = 696) were recruited through an undergraduate psychology subject pool and random selection of patients in a health system. In a cross-sectional survey, participants completed PARSS test items, measures of basic need satisfaction, behavioral regulation, and self-reported physical activity. Analyses included exploratory and confirmatory factor analyses and correlations to establish construct and criterion validity. The final measure included 6 items contributing to one latent factor. The measure was invariant to participants' physical activity preferences and demonstrated high internal consistency reliability (alpha = .94) and evidence for construct and criterion validity (positive associations with other relatedness measures, autonomy and competence satisfaction, autonomous motivation and physical activity). The PARSS offers a reliable tool for observational studies exploring the relationship between relatedness satisfaction and physical activity, and for intervention research targeting relatedness as a mechanism for promoting physical activity behavior change. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Hooker, Stephanie A AU - Hooker SA AD - Research and Evaluation Division, HealthPartners Institute, 8170 33rd Ave S., MS 21112R, Minneapolis, MN, 55425, USA. Electronic address: stephanie.a.hooker@healthpartners.com. FAU - LaCaille, Lara J AU - LaCaille LJ AD - Department of Psychology, University of Minnesota Duluth, 320 BohH 1207 Ordean Court, Duluth, MN, 55812, USA. Electronic address: llacaill@d.umn.edu. FAU - LaCaille, Rick A AU - LaCaille RA AD - Department of Psychology, University of Minnesota Duluth, 320 BohH 1207 Ordean Court, Duluth, MN, 55812, USA. Electronic address: rlacaill@d.umn.edu. FAU - Sikorski, Jonathon AU - Sikorski J AD - TRIA Orthopedics, HealthPartners, 8100 Northland Dr, Bloomington, MN, 55431, USA. Electronic address: jonathon.sikorski@parknicollet.com. LA - eng GR - R21 AG070161/AG/NIA NIH HHS/United States PT - Journal Article DEP - 20260114 PL - Netherlands TA - Psychol Sport Exerc JT - Psychology of sport and exercise JID - 101088724 SB - IM MH - Humans MH - Female MH - Psychometrics MH - Male MH - *Personal Satisfaction MH - Reproducibility of Results MH - Personal Autonomy MH - Cross-Sectional Studies MH - *Exercise/psychology MH - Adult MH - Young Adult MH - Surveys and Questionnaires MH - Adolescent MH - Motivation MH - Factor Analysis, Statistical MH - Middle Aged MH - *Interpersonal Relations PMC - PMC12922672 MID - NIHMS2140389 OTO - NOTNLM OT - Basic psychological need OT - Exercise OT - Measurement OT - Reliability OT - Self-determination theory OT - Validity COIS- Declaration of competing interest The authors have no conflicts of interest to declare. EDAT- 2026/01/17 00:37 MHDA- 2026/01/24 00:32 PMCR- 2027/01/14 CRDT- 2026/01/16 19:14 PHST- 2025/09/04 00:00 [received] PHST- 2026/01/12 00:00 [revised] PHST- 2026/01/13 00:00 [accepted] PHST- 2026/01/24 00:32 [medline] PHST- 2026/01/17 00:37 [pubmed] PHST- 2026/01/16 19:14 [entrez] PHST- 2027/01/14 00:00 [pmc-release] AID - S1469-0292(26)00008-7 [pii] AID - 10.1016/j.psychsport.2026.103068 [doi] PST - ppublish SO - Psychol Sport Exerc. 2026 Mar;83:103068. doi: 10.1016/j.psychsport.2026.103068. Epub 2026 Jan 14. PMID- 41543589 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260920 IS - 1436-6215 (Electronic) IS - 1436-6207 (Print) IS - 1436-6207 (Linking) VI - 65 IP - 1 DP - 2026 Jan 16 TI - Association between eating behaviours and food and beverage consumption in male and female children aged 3-6 years: The CORALS cohort. PG - 26 LID - 10.1007/s00394-025-03848-x [doi] LID - 26 AB - PURPOSE: Eating behaviours influence food intake and long-term eating habits. This study aimed to assess the association between specific eating behaviour traits and the consumption of food and beverage in children aged 3 to 6 years, based on data from the CORAL study. METHODS: Data were obtained from the Spanish CORAL study, a 10-year longitudinal cohort including 1407 participants (699 boys, 708 girls; 4.8 +/- 1.0 years). Eating behaviours were assessed using the Child Eating Behaviour Questionnaire (CEBQ) and dietary intake was measured using a validated COME-Kids Food and Beverage Frequency Questionnaire. Principal Component Analysis (PCA) was applied to identify dietary patterns. Associations were analysed with multivariable linear regression adjusted for covariates. RESULTS: In both sexes, higher Enjoyment of Food scores were associated with greater consumption of fish, fruits, vegetables, pulses, whole grains, and lower consumption of sweets. In contrast, higher Food Fussiness scores were associated with lower consumption of fruits, vegetables, fish, and pulses, and higher intake of sweets. PCA revealed five dietary patterns per sex, explaining 36.62% of the variance in boys and 36.07% in girls. Enjoyment of Food and Food Fussiness were the traits most strongly associated with distinct dietary patterns (p < 0.001). CONCLUSION: Eating behaviour traits are clearly associated with diet quality in early childhood. Enjoyment of Food supports healthier eating, while Food Fussiness may compromise it. These findings may inform early prevention strategies to encourage healthy eating habits and reduce the risk of childhood overweight and obesity. CI - (c) 2026. The Author(s). FAU - Maneschy, Ivie AU - Maneschy I AD - Growth, Exercise, NUtrition and Development (GENUD-B34_23R) Research Group. Instituto Agroalimentario de Aragon (IA2), Universidad de Zaragoza and Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. FAU - Ortega-Ramirez, Ana Daniela AU - Ortega-Ramirez AD AD - Faculty of Medicine, University of Colima, Av. Universidad 33 Colonia Las Viboras, 28010, Colima, CP, Mexico. FAU - Jimeno-Martinez, Andrea AU - Jimeno-Martinez A AD - Growth, Exercise, NUtrition and Development (GENUD-B34_23R) Research Group. Instituto Agroalimentario de Aragon (IA2), Universidad de Zaragoza and Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. FAU - Gil-Campos, Mercedes AU - Gil-Campos M AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. AD - Metabolism and Investigation Unit, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004, Cordoba, Spain. FAU - Leis, Rosaura AU - Leis R AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. AD - Unit of Pediatric Gastroenterology, Hepatology and Nutrition-Pediatrics Service. Hospital, Clinico Universitario de Santiago, Santiago de Compostela, Spain. AD - Pediatrics Nutrition Research Group-Health Research Institute of Santiago (IDIS)-ISCIII, Unit of Investigation in Nutrition, Growth and Human Development of Galicia (GALINUT), University of Santiago de Compostela, Santiago de Compostela, Spain. FAU - Babio, Nancy AU - Babio N AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. AD - Grup ANUT-DSM, Departament de Bioquimica i Biotecnologia, Universitat Rovira i Virgili, Unitat de Nutricio Humana, Reus, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. FAU - Navas-Carretero, Santiago AU - Navas-Carretero S AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. AD - Department of Nutrition Food Science & Physiology, University of Navarra, 31008, Pamplona, Spain. AD - Center for Nutrition Research, University of Navarra, 31008, Pamplona, Spain. AD - IdisNA, Navarra Institute for Health Research, Pamplona, Spain. FAU - Pastor-Villaescusa, Belen AU - Pastor-Villaescusa B AD - Metabolism and Investigation Unit, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004, Cordoba, Spain. AD - Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS, RD21/0012/0008); Spanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS-SAMID, RD24/0013/0007), Instituto de Salud Carlos III, Madrid, Spain. FAU - Vazquez-Cobela, Rocio AU - Vazquez-Cobela R AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. AD - Unit of Pediatric Gastroenterology, Hepatology and Nutrition-Pediatrics Service. Hospital, Clinico Universitario de Santiago, Santiago de Compostela, Spain. AD - Pediatrics Nutrition Research Group-Health Research Institute of Santiago (IDIS)-ISCIII, Unit of Investigation in Nutrition, Growth and Human Development of Galicia (GALINUT), University of Santiago de Compostela, Santiago de Compostela, Spain. FAU - Salas-Salvado, Jordi AU - Salas-Salvado J AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. AD - Grup ANUT-DSM, Departament de Bioquimica i Biotecnologia, Universitat Rovira i Virgili, Unitat de Nutricio Humana, Reus, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. FAU - De Miguel-Etayo, Pilar AU - De Miguel-Etayo P AD - Growth, Exercise, NUtrition and Development (GENUD-B34_23R) Research Group. Instituto Agroalimentario de Aragon (IA2), Universidad de Zaragoza and Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. pilardm@unizar.es. AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. pilardm@unizar.es. FAU - Martinez, Jose Alfredo AU - Martinez JA AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. AD - Department of Nutrition Food Science & Physiology, University of Navarra, 31008, Pamplona, Spain. AD - Center for Nutrition Research, University of Navarra, 31008, Pamplona, Spain. AD - Precision Nutrition and Cardiometabolic Health Program, IMDEA-Food Institute (Madrid Institute for Advanced Studies), CEI UAM + CSIC, Madrid, Spain. AD - INstittute of Endocrinology and Nutrition, University of Valladolid, Valladolid, Spain. FAU - Llorente-Cantarero, Francisco Jesus AU - Llorente-Cantarero FJ AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. AD - Metabolism and Investigation Unit, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004, Cordoba, Spain. FAU - Picans-Leis, Rosaura AU - Picans-Leis R AD - Servicio de Neonatologia, Instituto de Investigacion Sanitaria de Santiago (IDIS), Hospital Clinico Universitario de Santiago, Santiago de Compostela, Espana. FAU - Pallas, Natalia Ferre AU - Pallas NF AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. AD - Pediatrics, Nutrition and Development Research Unit (PediNuR), Universitat Rovira i Virgili, Reus, Spain. FAU - Ruperez, Azahara I AU - Ruperez AI AD - Growth, Exercise, NUtrition and Development (GENUD-B34_23R) Research Group. Instituto Agroalimentario de Aragon (IA2), Universidad de Zaragoza and Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. FAU - Jurado-Castro, Jose Manuel AU - Jurado-Castro JM AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. AD - Metabolism and Investigation Unit, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004, Cordoba, Spain. FAU - de la Torre-Aguilar, Maria Jose AU - de la Torre-Aguilar MJ AD - Metabolism and Investigation Unit, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004, Cordoba, Spain. FAU - Gheorghita, Irina AU - Gheorghita I AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. AD - Pediatrics, Nutrition and Development Research Unit (PediNuR), Universitat Rovira i Virgili, Reus, Spain. FAU - Moreno, Luis A AU - Moreno LA AD - Growth, Exercise, NUtrition and Development (GENUD-B34_23R) Research Group. Instituto Agroalimentario de Aragon (IA2), Universidad de Zaragoza and Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. FAU - Miguel-Berges, Maria L AU - Miguel-Berges ML AD - Growth, Exercise, NUtrition and Development (GENUD-B34_23R) Research Group. Instituto Agroalimentario de Aragon (IA2), Universidad de Zaragoza and Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. LA - eng PT - Journal Article DEP - 20260116 PL - Germany TA - Eur J Nutr JT - European journal of nutrition JID - 100888704 SB - IM MH - Humans MH - Female MH - Male MH - *Feeding Behavior/psychology MH - Child MH - Child, Preschool MH - Longitudinal Studies MH - *Diet/statistics & numerical data/methods MH - *Beverages/statistics & numerical data MH - Spain MH - Surveys and Questionnaires MH - Principal Component Analysis MH - Cohort Studies MH - Food Fussiness MH - *Child Behavior PMC - PMC12811333 OTO - NOTNLM OT - Child OT - Dietary intake OT - Eating behaviours OT - Foods consumption and beverages consumption COIS- Declarations. Conflicts of interest: The authors declare that they have no competing interests. EDAT- 2026/01/16 15:05 MHDA- 2026/01/16 15:06 PMCR- 2026/01/16 CRDT- 2026/01/16 11:05 PHST- 2025/02/26 00:00 [received] PHST- 2025/11/13 00:00 [accepted] PHST- 2026/01/16 15:06 [medline] PHST- 2026/01/16 15:05 [pubmed] PHST- 2026/01/16 11:05 [entrez] PHST- 2026/01/16 00:00 [pmc-release] AID - 10.1007/s00394-025-03848-x [pii] AID - 3848 [pii] AID - 10.1007/s00394-025-03848-x [doi] PST - epublish SO - Eur J Nutr. 2026 Jan 16;65(1):26. doi: 10.1007/s00394-025-03848-x. PMID- 41543554 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260920 IS - 1436-6215 (Electronic) IS - 1436-6207 (Print) IS - 1436-6207 (Linking) VI - 65 IP - 1 DP - 2026 Jan 16 TI - Do 6-9-year-old children in Denmark adhere to national dietary recommendations and are there sociodemographic disparities? The Generation Healthy Kids study. PG - 24 LID - 10.1007/s00394-025-03863-y [doi] LID - 24 AB - PURPOSE: Diet in childhood is important for growth, brain development, and long-term health. Thus, assessing children's adherence to dietary recommendations and identifying sociodemographic groups with low adherence is of great public health relevance. We investigated dietary intake, adherence to recommendations, and sociodemographic differences in a large cohort of Danish children. METHODS: We analyzed baseline data from 1094 children aged 6-9 years from 23 schools across Denmark participating in the Generation Healthy Kids study. Diet was assessed by three-day dietary records and food frequency questionnaires for fish and supplements, focusing on key food groups, macronutrients, and iron. Fasting blood samples were collected from n = 347 and analyzed for nutritional biomarkers of fish, wholegrains, and iron for validation. RESULTS: Overall adherence to dietary recommendations showed a mean +/- SD score of 4.6 +/- 1.0 out of 7.0. However, < 15% adhered to the recommendations for fruit + vegetables, fish, and meat, and < 33% to recommendations for saturated fat (SFA) and iron. Adherence decreased with age and shorter parental education, due to lower intakes of fruit + vegetables and dairy with age, and lower wholegrain and higher meat intake with shorter parental education. Also, rural children had lower adherence and consumed less fruit + vegetables and more added sugar and SFA than urban. Non-Danish descendants consumed less wholegrains and sugar than Danish, and weight status was not associated with adherence. CONCLUSIONS: Danish children had relatively good dietary adherence, but intakes of fruit + vegetables, fish, meat, SFA, and iron remain a concern. Attention should be given to children of older age, short parental education, and rural backgrounds. FAU - Holmegaard, Frederik AU - Holmegaard F AD - Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark. fhj@nexs.ku.dk. FAU - Eilersen, Anna Gro AU - Eilersen AG AD - Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark. FAU - Lauritzen, Lotte AU - Lauritzen L AD - Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark. FAU - Molgaard, Christian AU - Molgaard C AD - Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark. FAU - Liu, Ming Rong AU - Liu MR AD - Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, Canada. FAU - Stark, Ken D AU - Stark KD AD - Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, Canada. FAU - Landberg, Rikard AU - Landberg R AD - Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden. FAU - Krolner, Rikke Fredenslund AU - Krolner RF AD - National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. FAU - Toft, Ulla AU - Toft U AD - Department of Prevention, Health Promotion and Community Care, Steno Diabetes Center Copenhagen, Herlev, Denmark. FAU - Damsgaard, Camilla Trab AU - Damsgaard CT AD - Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark. LA - eng PT - Journal Article DEP - 20260116 PL - Germany TA - Eur J Nutr JT - European journal of nutrition JID - 100888704 SB - IM MH - Humans MH - Child MH - Denmark MH - Female MH - Male MH - *Diet/statistics & numerical data/methods MH - Socioeconomic Factors MH - *Nutrition Policy MH - Diet Records MH - *Recommended Dietary Allowances MH - Socioeconomic Disparities in Health MH - *Patient Compliance/statistics & numerical data MH - Cohort Studies MH - Fruit MH - Vegetables MH - Sociodemographic Factors MH - Diet Surveys MH - Child Nutritional Physiological Phenomena PMC - PMC12811282 OTO - NOTNLM OT - Children's dietary intake OT - Dietary recommendations OT - Public health OT - Sociodemographic disparities COIS- Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: The study was approved by the Ethics Committee of Southern Denmark (S-20220094). Consent to participate: All children received oral information, and custody holders received both written and oral information about the study before custody holders gave written informed consent for their child to participate. EDAT- 2026/01/16 15:04 MHDA- 2026/06/27 00:53 PMCR- 2026/01/16 CRDT- 2026/01/16 11:03 PHST- 2025/09/29 00:00 [received] PHST- 2025/12/03 00:00 [accepted] PHST- 2026/06/27 00:53 [medline] PHST- 2026/01/16 15:04 [pubmed] PHST- 2026/01/16 11:03 [entrez] PHST- 2026/01/16 00:00 [pmc-release] AID - 10.1007/s00394-025-03863-y [pii] AID - 3863 [pii] AID - 10.1007/s00394-025-03863-y [doi] PST - epublish SO - Eur J Nutr. 2026 Jan 16;65(1):24. doi: 10.1007/s00394-025-03863-y. PMID- 41543512 OWN - NLM STAT- MEDLINE DCOM- 20260116 LR - 20260626 IS - 2047-2986 (Electronic) IS - 2047-2978 (Print) IS - 2047-2978 (Linking) VI - 16 DP - 2026 Jan 16 TI - Development and external validation of an interpretable machine learning-based model for obesity risk prediction in 2-18-year-old children and adolescents in Beijing and Tangshan. PG - 04031 LID - 10.7189/jogh.16.04031 [doi] LID - 04031 AB - BACKGROUND: The multifactorial mechanisms driving childhood obesity, a global public health challenge, are yet to be fully elucidated. We aimed to develop and externally validate three widely applied machine learning models alongside logistic regression in 2-18-year-old children and adolescents in Beijing and Tangshan to predict obesity risk. As a further step, we wanted to interpret the optimised model and translate it into a web-based tool to inform clinical decision-making. METHODS: We analysed data of 19 024 (training/testing) and 2410 (external validation) children and adolescents from Beijing and Tangshan, respectively. Using a set of factors including demographic, familial, socioeconomic, lifestyle, and perinatal variables, we developed four models (light gradient boosting machine, random forest, eXtreme gradient boosting (XGBoost), and logistic regression) and compared their predictive performance. After validation, we selected an optimised model and interpreted it using SHapley Additive exPlanations (SHAP) analysis. Then, we developed an online calculator with interpretable visualisations to enable real-time risk assessment. RESULTS: The XGBoost model exhibited superior performance, with an area under the receiver operating characteristic curve (AUROC) of 0.875 on the external validation set, significantly outperforming the logistic regression model (AUROC = 0.718). To identify the minimal feature subset that maintained model efficacy, we incrementally incorporated predictors in the descending order of SHAP importance values while assessing key performance metrics (accuracy, AUROC, and F-beta score). This SHAP-based analysis identified nine key predictors of childhood obesity: birth length, paternal body mass index (BMI), maternal BMI, sleep duration, physical activity, birth weight, maternal age at delivery, delivery mode, and gestational age. The deployed online tool provides individualised risk probabilities and SHAP-derived explanations. CONCLUSIONS: The XGBoost model in our study was the superior ensemble learning method for predicting childhood obesity. The digital tool integrates this model and can help clinical practitioners determine individuals' risk of childhood obesity. CI - Copyright (c) 2026 by the Journal of Global Health. All rights reserved. FAU - Xue, Mei AU - Xue M AD - Graduate School, Beijing University of Chinese Medicine, Beijing, China. AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China. FAU - Liu, Shufang AU - Liu S AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China. FAU - Zhang, Xiaoqian AU - Zhang X AD - Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medicine University, National Center for Children's Health, Beijing, China. FAU - Zhang, Zhixin AU - Zhang Z AD - Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China. FAU - Niu, Wenquan AU - Niu W AD - Center for Evidence-Based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260116 PL - Scotland TA - J Glob Health JT - Journal of global health JID - 101578780 SB - IM MH - Humans MH - Adolescent MH - Female MH - Risk Assessment/methods MH - Predictive Learning Models MH - China/epidemiology MH - Child, Preschool MH - Child MH - Beijing/epidemiology MH - Male MH - *Pediatric Obesity/epidemiology MH - Boosting Machine Learning Algorithms MH - *Machine Learning MH - Logistic Models MH - Random Forest MH - Risk Factors MH - Prediction Algorithms PMC - PMC12810588 COIS- Disclosure of interest: The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests. EDAT- 2026/01/16 15:03 MHDA- 2026/01/16 15:04 PMCR- 2026/01/16 CRDT- 2026/01/16 10:52 PHST- 2026/01/16 15:04 [medline] PHST- 2026/01/16 15:03 [pubmed] PHST- 2026/01/16 10:52 [entrez] PHST- 2026/01/16 00:00 [pmc-release] AID - jogh-16-04031 [pii] AID - 10.7189/jogh.16.04031 [doi] PST - epublish SO - J Glob Health. 2026 Jan 16;16:04031. doi: 10.7189/jogh.16.04031. PMID- 41539531 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260803 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 220 DP - 2026 May 1 TI - Contribution of parental feeding practices and home environmental factors to the eating behaviours of preschool children. PG - 108461 LID - S0195-6663(26)00022-X [pii] LID - 10.1016/j.appet.2026.108461 [doi] AB - From family and ecological systems perspectives, parental feeding styles at the dyadic level play a proximal role in shaping young children's eating behaviours. However, far less is known about how broader family-level factors contribute to these behaviours. This cross-sectional study investigated the contribution of parental feeding styles and home environmental factors to the eating behaviours of preschool children. A total of 253 parent-child dyads were recruited from 16 kindergartens in Hong Kong, China. Parents completed validated questionnaires, namely the Parental Feeding Style Questionnaire and the Children's Eating Behaviour Questionnaire, which assessed feeding styles (instrumental, emotional, encouragement to eat, and control over eating), the home environmental factors (mealtime structure, mealtime distractions, and household chaos), and children's appetite-trait eating behaviours. Hierarchical multiple regression analyses, controlling for demographic variables, were conducted. Parental feeding styles explained 3-12 % of the variance in children's eating behaviours. Notably, control over eating was associated with lower emotional overeating and reduced food fussiness, as well as with lower satiety responsiveness (i.e., greater appetite). Adding home environmental factors explained an additional 15 % of the variance beyond feeding styles, with significant incremental contributions observed for desire to drink, food responsiveness, and slowness in eating. These findings underscore that both proximal feeding styles and family-level home environmental factors uniquely and additively shape preschool children's eating behaviours. Interventions should therefore promote not only responsive and structured parental feeding styles but also structured mealtimes, reduced mealtime distractions, and a more organised household environment to support healthy eating in children. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Wan, Alison Wing Lam AU - Wan AWL AD - Centre for Child and Family Science, The Education University of Hong Kong, China. FAU - Chan, Derwin King Chung AU - Chan DKC AD - Department of Social Sciences, Hong Kong Metropolitan University, China. FAU - Chung, Kevin Kien Hoa AU - Chung KKH AD - Centre for Child and Family Science, The Education University of Hong Kong, China; Department of Early Childhood Education, The Education University of Hong Kong, China. Electronic address: kevin@eduhk.hk. LA - eng PT - Journal Article DEP - 20260113 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Child, Preschool MH - Female MH - Male MH - *Feeding Behavior/psychology MH - Cross-Sectional Studies MH - *Parenting/psychology MH - Hong Kong MH - *Child Behavior/psychology MH - Surveys and Questionnaires MH - *Home Environment MH - *Parent-Child Relations MH - Meals MH - Appetite MH - Parents/psychology MH - Emotional Eating MH - Food Fussiness OTO - NOTNLM OT - Appetitive traits OT - Early childhood OT - Feeding styles OT - Household chaos OT - Incremental contribution OT - Mealtime environment COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/01/16 17:21 MHDA- 2026/02/21 00:56 CRDT- 2026/01/15 19:22 PHST- 2025/10/30 00:00 [received] PHST- 2025/12/10 00:00 [revised] PHST- 2026/01/13 00:00 [accepted] PHST- 2026/02/21 00:56 [medline] PHST- 2026/01/16 17:21 [pubmed] PHST- 2026/01/15 19:22 [entrez] AID - S0195-6663(26)00022-X [pii] AID - 10.1016/j.appet.2026.108461 [doi] PST - ppublish SO - Appetite. 2026 May 1;220:108461. doi: 10.1016/j.appet.2026.108461. Epub 2026 Jan 13. PMID- 41539432 OWN - NLM STAT- MEDLINE DCOM- 20260323 LR - 20260626 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 72 DP - 2026 Apr TI - Comparing the eating attitudes test (EAT -26) and disorder examination questionnaire (EDE-Q) as screening tools for eating disorders among young adults: A population-specific analysis. PG - 102917 LID - S2405-4577(26)00012-4 [pii] LID - 10.1016/j.clnesp.2026.102917 [doi] AB - BACKGROUND AND AIMS: Eating disorders (EDs) are an emerging issue worldwide. The Eating Disorder Examination Questionnaire (EDE-Q) and the Eating Attitudes Test (EAT) are widely used research standards for evaluating EDs. This study aims to examine and determine the best ED scoring system, which tool demonstrates stronger associations for specific population subgroups, and the determinants for each scoring system in identifying EDs. METHODS: A total of 1267 young adults were enrolled in a cross-sectional study. Anthropometric and general characteristics were collected, and EDs were assessed using the EDE-Q and the EAT-26. Several inter-rater reliability indicators were computed, and a logistic regression model was employed to identify the determinants of EDs. RESULTS: Across both scoring systems, higher BMI categories were significantly related to a higher likelihood (OR) of disordered eating. Compared to the EAT-26, the EDE-Q found significantly more disordered behaviors, particularly among females and those who were overweight or obese. Moderate agreement (Po = 0.666; kappa = 0.281) and significant asymmetry (p < 0.001) were found between the two scales, suggesting that they capture distinct symptom patterns. BMI, female sex, and physical inactivity were significant predictors of disordered eating in multivariable analyses; the EAT-26 showed stronger correlations with physical inactivity, and the EDE-Q showed stronger associations with weight-related symptoms and female sex. CONCLUSION: The EAT-26 and EDE-Q captured different patterns of disordered eating, with the EDE-Q identifying more cases, especially among overweight and obese females. Agreement between tools was modest, and BMI, female sex, and physical inactivity were significant predictors of disordered-eating risk. These findings highlight the need to select screening tools based on population characteristics and symptom profiles. CI - Copyright (c) 2026 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. FAU - Agraib, Lana M AU - Agraib LM AD - Department of Nutrition and Food Science, Faculty of Allied Medical Sciences, Al-Balqa Applied University, Al-Salt, Jordan. Electronic address: Lanamg2007@bau.edu.jo. FAU - Al-Shami, Islam AU - Al-Shami I AD - Department of Clinical Nutrition and Dietetics, Faculty of Applied Medical Sciences, Hashemite University, Zarqa, Jordan. Electronic address: islamk@hu.edu.jo. FAU - Alkhatib, Buthaina AU - Alkhatib B AD - Department of Clinical Nutrition and Dietetics, Faculty of Applied Medical Sciences, Hashemite University, Zarqa, Jordan. Electronic address: bkhatib@hu.edu.jo. FAU - Orabi, Aliaa AU - Orabi A AD - Department of Nutrition and Food Technology, Faculty of Agriculture, The University of Jordan, Amman, Jordan. Electronic address: aliaajorabi@gmail.com. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260113 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM MH - Humans MH - Female MH - *Feeding and Eating Disorders/diagnosis/epidemiology/psychology MH - Surveys and Questionnaires MH - Male MH - Cross-Sectional Studies MH - Young Adult MH - Body Mass Index MH - Reproducibility of Results MH - Adult MH - Obesity MH - Adolescent MH - *Feeding Behavior MH - Logistic Models MH - Mass Screening/methods OTO - NOTNLM OT - EAT-26 OT - EDE-Q OT - Eating disorders OT - Obesity OT - Physical inactivity OT - adults COIS- Declaration of competing interest The authors have no conflicts of interest to disclose. EDAT- 2026/01/16 17:21 MHDA- 2026/03/23 06:31 CRDT- 2026/01/15 19:16 PHST- 2025/09/27 00:00 [received] PHST- 2025/12/16 00:00 [revised] PHST- 2026/01/07 00:00 [accepted] PHST- 2026/03/23 06:31 [medline] PHST- 2026/01/16 17:21 [pubmed] PHST- 2026/01/15 19:16 [entrez] AID - S2405-4577(26)00012-4 [pii] AID - 10.1016/j.clnesp.2026.102917 [doi] PST - ppublish SO - Clin Nutr ESPEN. 2026 Apr;72:102917. doi: 10.1016/j.clnesp.2026.102917. Epub 2026 Jan 13. PMID- 41539167 OWN - NLM STAT- MEDLINE DCOM- 20260602 LR - 20260626 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 144 DP - 2026 Apr TI - Adherence to the Mediterranean diet and depressive symptoms. A cross-sectional study among Italian university students: The UniFoodWaste study. PG - 113070 LID - S0899-9007(25)00387-9 [pii] LID - 10.1016/j.nut.2025.113070 [doi] AB - BACKGROUND: Depression is a major global health issue and is particularly prevalent among university students. Emerging evidence suggests that dietary patterns, especially the Mediterranean diet (MD), may influence mental health. This study aimed to examine the association between adherence to the MD and depressive symptoms among Italian university students. STUDY DESIGN: Cross-sectional study. METHODS: A cross-sectional, web-based survey was conducted among students aged >/=18 y enrolled at the University of Milan (N = 2697). Adherence to the MD was assessed using the validated Medi-Lite score (range 0-18), while depressive symptoms were measured with the Patient Health Questionnaire-9 (PHQ-9), analyzed both as a continuous variable and using established cut-offs (>/=5 and >/=10). Multivariable logistic and linear regression models were used to assess associations between MD adherence, individual dietary components, and depressive symptoms, adjusting for age and sex. RESULTS: Higher MD adherence was significantly associated with fewer depressive symptoms. Each one-point increase in the Medi-Lite score was linked to lower odds of PHQ-9 >/= 10 (aOR = 0.91, 95% confidence interval [CI]: 0.88-0.95; P = 0.001), PHQ-9 >/= 5 (aOR = 0.89, 95% CI: 0.85-0.93; P < 0.001), and reduced PHQ-9 scores (beta = -0.02, 95% CI: -0.03 to -0.01; P = 0.001). Consuming >2 portions/d of fruit (aOR = 0.60, 95% CI: 0.45-0.80; P = 0.001) and >2.5 portions/d of vegetables (aOR = 0.62, 95% CI: 0.45-0.85; P = 0.003) was associated with lower odds of depressive symptoms; vegetable intake also correlated with lower PHQ-9 scores (beta = -0.14, 95% CI: -0.23 to -0.06; P = 0.001). Reduced meat intake (<1 portion/d) and regular olive oil use were further linked to lower depressive symptomatology. In contrast, alcohol consumption of 1 to 2 units/d (aOR = 1.41, 95% CI: 1.10-1.79; P = 0.006) and frequent use of food waste apps (>/=1/wk: aOR = 4.26, 95% CI: 1.18-15.34; P = 0.027; beta = 0.38, 95% CI: 0.00-0.76; P = 0.049) were associated with increased depressive symptoms. CONCLUSIONS: Greater adherence to the MD was associated with lower depressive symptoms among university students. Promoting MD adherence in student health programs may offer a useful non-pharmacological strategy to support mental well-being. CI - Copyright (c) 2025 Elsevier Inc. All rights reserved. FAU - Pennisi, Flavia AU - Pennisi F AD - Faculty of Medicine, University Vita-Salute San Raffaele, Milan, Italy; PhD National Program in One Health Approaches to Infectious Diseases and Life Science Research Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy. FAU - Nucci, Daniele AU - Nucci D AD - PhD National Program in One Health Approaches to Infectious Diseases and Life Science Research Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy; Dipartimento di Igiene e Prevenzione Sanitaria, Agenzia di Tutela della Salute (ATS) Brescia, Struttura Semplice Dipartimentale Igiene Alimenti e Nutrizione, Brescia, Italy. FAU - Pinto, Antonio AU - Pinto A AD - Faculty of Medicine, University Vita-Salute San Raffaele, Milan, Italy. Electronic address: pinto.antonio@hsr.it. FAU - Stacchini, Lorenzo AU - Stacchini L AD - Dipartimento Sanita Territoriale, USL Toscana Nord Ovest, Pisa, Italy. FAU - Veronese, Nicola AU - Veronese N AD - Saint Camillus International University of Health Sciences, Faculty of Medicine, Rome, Italy. FAU - Maggi, Stefania AU - Maggi S AD - Fondazione Dieta Mediterranea, Rome, Italy. FAU - Signorelli, Carlo AU - Signorelli C AD - Faculty of Medicine, University Vita-Salute San Raffaele, Milan, Italy. FAU - Baldo, Vincenzo AU - Baldo V AD - Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padua, Padova, Veneto, Italy. FAU - Gianfredi, Vincenza AU - Gianfredi V AD - Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padua, Padova, Veneto, Italy. LA - eng PT - Journal Article DEP - 20251219 PL - United States TA - Nutrition JT - Nutrition (Burbank, Los Angeles County, Calif.) JID - 8802712 SB - IM MH - Humans MH - *Diet, Mediterranean/statistics & numerical data/psychology MH - Cross-Sectional Studies MH - Female MH - *Depression/epidemiology/prevention & control MH - Male MH - Italy/epidemiology MH - *Students/statistics & numerical data/psychology MH - Universities MH - Young Adult MH - Adolescent MH - Adult MH - Surveys and Questionnaires MH - Feeding Behavior/psychology MH - *Patient Compliance/statistics & numerical data OTO - NOTNLM OT - Depressive symptoms OT - Mediterranean diet OT - Mental health OT - Nutritional epidemiology OT - University students COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships, which may be considered as potential competing interests: Vincenza Gianfredi reports financial support was provided by University of Milan. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article. EDAT- 2026/01/16 17:21 MHDA- 2026/02/14 05:30 CRDT- 2026/01/15 18:15 PHST- 2025/09/16 00:00 [received] PHST- 2025/12/13 00:00 [revised] PHST- 2025/12/15 00:00 [accepted] PHST- 2026/02/14 05:30 [medline] PHST- 2026/01/16 17:21 [pubmed] PHST- 2026/01/15 18:15 [entrez] AID - S0899-9007(25)00387-9 [pii] AID - 10.1016/j.nut.2025.113070 [doi] PST - ppublish SO - Nutrition. 2026 Apr;144:113070. doi: 10.1016/j.nut.2025.113070. Epub 2025 Dec 19. PMID- 41538793 OWN - NLM STAT- MEDLINE DCOM- 20260115 LR - 20260202 IS - 1438-8871 (Electronic) IS - 1439-4456 (Print) IS - 1438-8871 (Linking) VI - 28 DP - 2026 Jan 15 TI - Leisure Screen Time, Internet Gaming Disorder, and Mental Health Among Chinese Adolescents: Large-Scale Cross-Sectional Study. PG - e80737 LID - 10.2196/80737 [doi] LID - e80737 AB - BACKGROUND: Adolescence is a critical period for mental health vulnerability alongside rising digital media exposure. Current evidence often fails to distinguish the distinct roles of leisure screen time (LST) quantity and addictive patterns like internet gaming disorder (IGD) on a comprehensive range of mental health outcomes. OBJECTIVE: This study aimed to investigate the independent and joint associations of LST and IGD with multiple mental health conditions among Chinese adolescents. METHODS: We conducted a school-based, cross-sectional survey in Sichuan Province, China. Participants were recruited by random cluster sampling from 20 public schools. The sample comprised 13,240 adolescents (6659/13,240, 50.3% girls) with a mean age of 15.4 (SD 1.6) years. LST was self-reported, and IGD was evaluated using the Internet Gaming Disorder Scale-9 Item Short Form (IGDS9-SF). Mental health outcomes included overall mental health status and 5 specific diseases: psychological distress, depression, paranoia, insomnia, and suicidal ideation, all assessed using validated scales. RESULTS: The prevalence of excessive LST, IGD, and any mental health disorder was 48.2% (6378/13,240; 95% CI 47.3%-49.0%), 1.4% (188/13,240; 95% CI 1.2%-1.6%), and 55.8% (7387/13,240; 95% CI 54.9%-56.7%), respectively. After adjustment, excessive LST (odds ratio [OR] 1.18, 95% CI 1.09-1.27) and IGD (OR 6.58, 95% CI 5.02-8.62) were independently associated with poor mental health. A dose-response relationship existed for LST quartiles (Q2: OR 1.15, 95% CI 1.04-1.26; Q3: OR 1.24, 95% CI 1.12-1.37; Q4: OR 1.31, 95% CI 1.18-1.46; P(trend)<.001). Excessive LST was associated with depression (OR 1.16, 95% CIs 1.05-1.29), paranoia (OR 1.22, 95% CI 1.11-1.34), and suicidal ideation (OR 1.15, 95% CI 1.04-1.28), while IGD was associated with all 5 disorders, most notably depression (OR 6.43, 95% CI 4.56-9.06) and paranoia (OR 5.77, 95% CI 4.05-8.21). IGD consistently demonstrated stronger associations than LST: psychological distress (OR 4.40, 95% CI 3.12-6.19 vs OR 1.14, 95% CI 0.98-1.33), depression (OR 6.43, 95% CI 4.56-9.06 vs OR 1.16, 95% CI 1.05-1.29), paranoia (OR 5.77, 95% CI 4.05-8.21 vs OR 1.22, 95% CI 1.11-1.34), insomnia (OR 2.90, 95% CI 2.09-4.05 vs OR 1.12, 95% CI 102-1.22), and suicidal ideation (OR 3.85, 95% CI 2.76-5.37 vs OR 1.15, 95% CI 1.04-1.28). Adolescents with both excessive LST and IGD demonstrated the highest odds of mental health disorders (OR 7.35, 95% CI 5.29-10.22). No significant interaction was found on additive or multiplicative scales. CONCLUSIONS: Both excessive LST and IGD are independently associated with mental health disorders in adolescents, with IGD showing a substantially stronger association. This study is distinct from prior research by simultaneously investigating both screen time quantity and addictive usage patterns, and by comprehensively assessing 5 distinct mental health outcomes. Longitudinal studies are needed to better understand the long-term effects. CI - (c)Qin Deng, Linna Sha, Jiaojiao Hou, Xunying Zhao, Rong Xiang, Jiangbo Zhu, Yang Qu, Jinyu Zhou, Ting Yu, Xin Song, Sirui Zheng, Tao Han, Bin Yang, Mengyu Fan, Xia Jiang. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 15.01.2026. FAU - Deng, Qin AU - Deng Q AUID- ORCID: 0009-0000-7330-867X AD - Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Sha, Linna AU - Sha L AUID- ORCID: 0009-0005-7117-8804 AD - Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Hou, Jiaojiao AU - Hou J AUID- ORCID: 0009-0001-4073-2711 AD - Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Zhao, Xunying AU - Zhao X AUID- ORCID: 0000-0002-6754-9773 AD - Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Xiang, Rong AU - Xiang R AUID- ORCID: 0000-0002-0123-5544 AD - Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Zhu, Jiangbo AU - Zhu J AUID- ORCID: 0009-0007-3481-0350 AD - Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Qu, Yang AU - Qu Y AUID- ORCID: 0009-0001-0679-0504 AD - Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Zhou, Jinyu AU - Zhou J AUID- ORCID: 0009-0004-6205-0828 AD - Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Yu, Ting AU - Yu T AUID- ORCID: 0000-0002-2294-3291 AD - Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Song, Xin AU - Song X AUID- ORCID: 0000-0003-2343-5835 AD - Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Zheng, Sirui AU - Zheng S AUID- ORCID: 0009-0003-4866-9635 AD - Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Han, Tao AU - Han T AUID- ORCID: 0009-0009-9672-8277 AD - Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Yang, Bin AU - Yang B AUID- ORCID: 0009-0007-0248-3164 AD - Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Fan, Mengyu AU - Fan M AUID- ORCID: 0009-0006-9803-0532 AD - Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Jiang, Xia AU - Jiang X AUID- ORCID: 0000-0001-5878-8986 AD - Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. AD - Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. AD - Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. LA - eng PT - Journal Article DEP - 20260115 PL - Canada TA - J Med Internet Res JT - Journal of medical Internet research JID - 100959882 RN - Chinese people SB - IM MH - Humans MH - Cross-Sectional Studies MH - Adolescent MH - Female MH - Male MH - China/epidemiology MH - *Internet Addiction Disorder/epidemiology/psychology MH - *Mental Health MH - *Screen Time MH - *Leisure Activities MH - *Video Games MH - Mental Disorders/epidemiology MH - Surveys and Questionnaires MH - East Asian People PMC - PMC12856396 OTO - NOTNLM OT - adolescent OT - cross-sectional study OT - internet gaming disorder OT - leisure screen time OT - mental health OT - screen media activity COIS- Conflicts of Interest: None declared. EDAT- 2026/01/15 18:47 MHDA- 2026/01/15 18:48 PMCR- 2026/01/15 CRDT- 2026/01/15 16:56 PHST- 2025/07/15 00:00 [received] PHST- 2025/11/07 00:00 [accepted] PHST- 2026/01/15 18:48 [medline] PHST- 2026/01/15 18:47 [pubmed] PHST- 2026/01/15 16:56 [entrez] PHST- 2026/01/15 00:00 [pmc-release] AID - v28i1e80737 [pii] AID - 10.2196/80737 [doi] PST - epublish SO - J Med Internet Res. 2026 Jan 15;28:e80737. doi: 10.2196/80737. PMID- 41536385 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260115 LR - 20260117 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 17 IP - 12 DP - 2025 Dec TI - Identification and Evaluation of Menstruation-Related Disorders in Adolescent Girls Attending a Tertiary Care Center: An Observational Study. PG - e99192 LID - 10.7759/cureus.99192 [doi] LID - e99192 AB - Background Menstrual disorders such as dysmenorrhea, menorrhagia, oligomenorrhea, and premenstrual syndrome are believed to be the most common yet under-recognized causes of morbidity in adolescent girls. Many adolescents around the world experience menstrual dysfunction, and in India, cultural stigma, poor awareness, and nutritional imbalance are believed to exacerbate the burden. Despite national initiatives focusing on menstrual hygiene and anemia prevention, only a few studies in India have systematically evaluated the clinical spectrum, determinants, and functional impact of menstrual disorders in tertiary-care settings. This study aimed to assess the prevalence, pattern, and clinical correlates of menstruation-related disorders among adolescent girls attending a teaching hospital in South India and to identify the functional limitations imposed by these conditions. Methods A hospital-based cross-sectional observational study was conducted among 72 post-menarcheal adolescent girls (10-19 years) attending the outpatient department of Obstetrics and Gynecology, Sree Balaji Medical College and Hospital, Chennai. Participants were assessed using a validated, semi-structured questionnaire covering sociodemographic data, menstrual characteristics, hygiene practices, and psychosocial impact. Clinical evaluation included anthropometry, hemoglobin estimation, thyroid function testing, and pelvic ultrasonography where indicated. The severity of symptoms and functional disability were assessed using the Pictorial Blood Assessment Chart (PBAC), Visual Analogue Scale (VAS), and WHO Disability Assessment Schedule (WHODAS 2.0). Results The mean age at menarche was 12.6 +/- 1.2 years, with 69.4% reporting regular cycles and a mean duration of flow of 4.9 +/- 1.6 days. The overall prevalence of menstrual disorders was strikingly high (94.4%). Dysmenorrhea (72.2%) and premenstrual syndrome (75.0%) were the most common, followed by menorrhagia (25%) and oligomenorrhea (13.9%). Anemia was observed in 33.3%, thyroid abnormalities in 8.3%, and polycystic ovary syndrome (PCOS) features in 13.9% on ultrasonography. Overweight and obesity were significantly associated with menstrual irregularities (p=0.013). Functionally, participants missed an average of 1.8 +/- 0.9 school days per cycle, with 38.9% reporting absenteeism and 47.2% restricting social or physical activities. The mean WHODAS disability score was 8.6 +/- 3.5, showing a strong correlation (r=0.62; p<0.001) with menstrual symptom severity. Conclusion Menstrual disorders are highly prevalent among adolescents and impose significant physical and psychosocial burdens. Integrating menstrual health education, nutritional interventions, and early clinical screening into adolescent programs is vital to improving reproductive health and educational outcomes. CI - Copyright (c) 2025, Prem et al. FAU - Prem, Pragya AU - Prem P AD - Obstetrics and Gynaecology, Sree Balaji Medical College and Hospital, Chennai, IND. FAU - S R, Veena AU - S R V AD - Obstetrics and Gynaecology, Sree Balaji Medical College and Hospital, Chennai, IND. FAU - T S, Meena AU - T S M AD - Obstetrics and Gynaecology, Sree Balaji Medical College and Hospital, Chennai, IND. FAU - T G, Revathy AU - T G R AD - Obstetrics and Gynaecology, Sree Balaji Medical College and Hospital, Chennai, IND. LA - eng PT - Journal Article DEP - 20251214 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC12798763 OTO - NOTNLM OT - adolescent health OT - anemia OT - dysmenorrhea OT - india OT - menorrhagia OT - menstrual hygiene OT - premenstrual syndrome OT - school absenteeism OT - whodas COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Human Ethics Committee, Sree Balaji Medical College and Hospital issued approval 002/SBMCH/IHEC/2025/2535. Ethical approval for the study was obtained from the Institutional Human Ethics Committee of Sree Balaji Medical College and Hospital, Chennai (Ref No: 002/SBMCH/IHEC/2025/2535). Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/01/15 07:55 MHDA- 2026/01/15 07:56 PMCR- 2025/12/14 CRDT- 2026/01/15 04:24 PHST- 2025/12/14 00:00 [accepted] PHST- 2026/01/15 07:56 [medline] PHST- 2026/01/15 07:55 [pubmed] PHST- 2026/01/15 04:24 [entrez] PHST- 2025/12/14 00:00 [pmc-release] AID - 10.7759/cureus.99192 [doi] PST - epublish SO - Cureus. 2025 Dec 14;17(12):e99192. doi: 10.7759/cureus.99192. eCollection 2025 Dec. PMID- 41536238 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260827 IS - 1949-0984 (Electronic) IS - 1949-0976 (Print) IS - 1949-0976 (Linking) VI - 18 IP - 1 DP - 2026 Dec 31 TI - Maternal obesity alters human milk oligosaccharides content and correlates with early acquisition of late colonizers in the neonatal gut microbiome. PG - 2607043 LID - 10.1080/19490976.2025.2607043 [doi] LID - 2607043 AB - Metabolic and immune development in neonates are shaped by the succession of the gut microbiome. Maternal obesity can perturb this process by altering interactions of human milk bioactive elements, including oligosaccharides (HMOs), microbial populations, and metabolites. We conducted a longitudinal study of Mexican mother-infant dyads to examine maternal BMI-associated variations in HMOs and infant fecal microbiota. Breastmilk samples from 97 mothers were collected at 48 h, one month, and three months postpartum. We used targeted and untargeted metabolomics to profile breastmilk samples, while shotgun metagenomics was used to analyze infant fecal microbiome composition in a subset of samples. Mothers with obesity showed decreased concentration of key HMOs shortly after birth, correlating with an altered succession of their infant's gut microbiota. This included reduced early colonizers (Enterobacteriaceae) and increased abundance of intermediate and late colonizers (Bifidobacterium and members of the Lachnospiraceae family), over subsequent months. These taxa negatively correlated with HMOs such as 6'SL, LNnT, and LNT. Additionally, functional profiling revealed alterations in metabolic pathways related to polyamine biosynthesis, suggesting changes in microbial metabolism linked to maternal BMI. Despite the cohort's size, our study offers unique insights into the relationship between maternal obesity, HMO composition, and early infant microbial colonization in Latin-American mothers. This exploratory research serves as proof of concept, underscoring the need for larger-scale studies to validate these findings and better understand their implications for infant health. More importantly, our results highlight the interplay between maternal BMI and human milk bioactives, underscoring the importance of correlating microbial succession with maternal metabolic health to better understand early immune development in neonates. FAU - Corona-Cervantes, Karina AU - Corona-Cervantes K AUID- ORCID: 0000-0003-1370-9601 AD - Tecnologico de Monterrey, Institute for Obesity Research, Monterrey, NL, Mexico. AD - Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Monterrey, NL, Mexico. FAU - Urrutia-Baca, Victor H AU - Urrutia-Baca VH AUID- ORCID: 0000-0002-5929-5160 AD - Tecnologico de Monterrey, Institute for Obesity Research, Monterrey, NL, Mexico. FAU - Gamez-Valdez, July S AU - Gamez-Valdez JS AUID- ORCID: 0000-0001-7115-3678 AD - Tecnologico de Monterrey, Institute for Obesity Research, Monterrey, NL, Mexico. AD - Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Monterrey, NL, Mexico. FAU - Jimenez-Lopez, Brenda AU - Jimenez-Lopez B AUID- ORCID: 0009-0003-4242-133X AD - Tecnologico de Monterrey, Institute for Obesity Research, Monterrey, NL, Mexico. AD - Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Monterrey, NL, Mexico. FAU - Rodriguez-Gutierrez, Nora A AU - Rodriguez-Gutierrez NA AUID- ORCID: 0000-0003-1972-0625 AD - Hospital Regional Materno Infantil, Servicios de Salud de Nuevo Leon, OPD, Ciudad Guadalupe, NL, Mexico. FAU - Chavez-Caraza, Karla AU - Chavez-Caraza K AD - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, NL, Mexico. FAU - Espiricueta-Candelaria, Francisca AU - Espiricueta-Candelaria F AUID- ORCID: 0009-0005-6943-7790 AD - Tecnologico de Monterrey, Institute for Obesity Research, Monterrey, NL, Mexico. FAU - Villalobos, Ulises A Salas AU - Villalobos UAS AUID- ORCID: 0000-0002-7702-6458 AD - Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Monterrey, NL, Mexico. FAU - Ramos-Parra, Perla A AU - Ramos-Parra PA AUID- ORCID: 0000-0002-8972-8035 AD - Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Monterrey, NL, Mexico. FAU - Uribe, Janet A Gutierrez AU - Uribe JAG AUID- ORCID: 0000-0003-1056-7126 AD - Tecnologico de Monterrey, Institute for Obesity Research, Monterrey, NL, Mexico. AD - Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Monterrey, NL, Mexico. FAU - Brunck, Marion AU - Brunck M AUID- ORCID: 0000-0001-8994-8276 AD - Tecnologico de Monterrey, Institute for Obesity Research, Monterrey, NL, Mexico. AD - Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Monterrey, NL, Mexico. FAU - Chuck-Hernandez, Cristina AU - Chuck-Hernandez C AUID- ORCID: 0000-0002-3555-4826 AD - Tecnologico de Monterrey, Institute for Obesity Research, Monterrey, NL, Mexico. AD - Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Monterrey, NL, Mexico. FAU - Licona-Cassani, Cuauhtemoc AU - Licona-Cassani C AUID- ORCID: 0000-0002-0360-3945 AD - Tecnologico de Monterrey, Institute for Obesity Research, Monterrey, NL, Mexico. AD - Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Monterrey, NL, Mexico. AD - Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico. LA - eng SI - SRA/SUB15262662 SI - BioProject/PRJNA1260751 PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260115 PL - United States TA - Gut Microbes JT - Gut microbes JID - 101495343 RN - 0 (Oligosaccharides) SB - IM MH - Humans MH - *Milk, Human/chemistry/metabolism MH - Female MH - *Oligosaccharides/metabolism/analysis MH - Infant, Newborn MH - Feces/microbiology MH - Adult MH - *Gastrointestinal Microbiome MH - Pregnancy MH - Longitudinal Studies MH - *Bacteria/classification/isolation & purification/genetics/metabolism MH - *Obesity/metabolism/microbiology MH - Infant MH - Mexico MH - Body Mass Index MH - Metagenomics MH - Young Adult MH - *Pregnancy in Obesity/metabolism/microbiology MH - Mothers PMC - PMC12818807 OTO - NOTNLM OT - HMOs OT - gut microbiome OT - human milk OT - metagenomics OT - obesity OT - succession of gut microbiome COIS- The authors report that there are no competing interests to declare. EDAT- 2026/01/15 07:55 MHDA- 2026/01/15 07:56 PMCR- 2026/01/15 CRDT- 2026/01/15 04:03 PHST- 2026/01/15 07:56 [medline] PHST- 2026/01/15 07:55 [pubmed] PHST- 2026/01/15 04:03 [entrez] PHST- 2026/01/15 00:00 [pmc-release] AID - 2607043 [pii] AID - 10.1080/19490976.2025.2607043 [doi] PST - ppublish SO - Gut Microbes. 2026 Dec 31;18(1):2607043. doi: 10.1080/19490976.2025.2607043. Epub 2026 Jan 15. PMID- 41536000 OWN - NLM STAT- MEDLINE DCOM- 20260210 LR - 20260626 IS - 2072-1315 (Electronic) IS - 1606-0997 (Print) IS - 1606-0997 (Linking) VI - 45 IP - 1 DP - 2026 Jan 14 TI - A comparative study of ordinal logistic regression and machine learning models for predicting women's malnutrition in bangladesh: evidence from BDHS 2022. PG - 56 LID - 10.1186/s41043-025-01236-z [doi] LID - 56 AB - Malnutrition, including both undernutrition and overnutrition, remains a major public health concern in Bangladesh, particularly among women of reproductive age. This study aims to identify key determinants of women's malnutrition in Bangladesh and compare the predictive performance of ordinal logistic regression and machine learning methods for predicting women's malnutrition using data from the 2022 Bangladesh Demographic and Health Survey. This study utilized data from 8,728 ever-married women aged 15-49 years extracted from the BDHS 2022. Six ML algorithms, including Random Forest, Extreme Gradient Boosting (XGBoost), Support Vector Machine, Naive Bayes, AdaBoost, and Multilayer Perceptron (MLP), were compared with ordinal logistic regression by evaluating their performances using accuracy, precision, recall, [Formula: see text] score, Cohen's kappa, and area under the curve (AUC). Data preprocessing included SMOTE to address class imbalance, and models were assessed using stratified k-fold cross-validation. Findings of Ordinal Logistic Regression (OLR) suggest that age, division, residence, wealth index, current breastfeeding status, husband's education, currently working, and age at first marriage are the significant predictors of women's malnutrition. However, its predictive performance was modest, with an accuracy of 49% and macro-averaged [Formula: see text] score was 0.47. In contrast, ML models outperformed OLR across all evaluation metrics. Random Forest and XGBoost achieved the highest test accuracy (64%), with Random Forest attaining a macro-averaged [Formula: see text] score of 0.64 and achieved 66.2% accuracy (10-fold CV). Traditional models, such as OLR, are more explainable, but machine learning models demonstrate higher accuracy in classifying malnutrition. The findings can help policymakers and health professionals prioritize resources and plan targeted nutrition programs, considering the risk factors identified in this study, to lessen the burden of both undernutrition and overnutrition among women in Bangladesh. CI - (c) 2026. The Author(s). FAU - Kulsum, Umme AU - Kulsum U AD - Department of Statistics and Data Science, University of Barishal, Barishal, 8254, Bangladesh. FAU - Haque, Ahsanul AU - Haque A AD - Department of Statistics and Data Science, University of Barishal, Barishal, 8254, Bangladesh. FAU - Barai, Pallab AU - Barai P AD - Department of Statistics and Data Science, University of Barishal, Barishal, 8254, Bangladesh. FAU - Hossain, Md Moyazzem AU - Hossain MM AUID- ORCID: 0000-0003-3593-6936 AD - Department of Statistics and Data Science, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh. hossainmm@juniv.edu. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260114 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 SB - IM MH - Female MH - Humans MH - Bangladesh/epidemiology MH - *Malnutrition/epidemiology/diagnosis MH - Logistic Models MH - Adult MH - *Machine Learning MH - Middle Aged MH - Adolescent MH - Predictive Learning Models MH - Young Adult MH - Boosting Machine Learning Algorithms MH - Random Forest MH - Classification Algorithms MH - Health Surveys MH - Prediction Algorithms PMC - PMC12888648 OTO - NOTNLM OT - Bangladesh OT - Machine learning OT - Malnutrition OT - Ordinal logistic regression COIS- Declarations. Ethics approval and consent to participate: This study is based on publicly available secondary data. The initial survey obtained participants' consent, and ethical approval was granted by the Ethics Committee of the ICF Macro at Calverton in the USA and the local Ethics Committee in Bangladesh. Consent to participate: Confirming that all participants provided informed and voluntary consent before being interviewed or undergoing biomarker tests. Competing interests: The authors declare no competing interests. EDAT- 2026/01/15 07:55 MHDA- 2026/02/10 06:31 PMCR- 2026/01/14 CRDT- 2026/01/15 00:22 PHST- 2025/11/03 00:00 [received] PHST- 2025/12/28 00:00 [accepted] PHST- 2026/02/10 06:31 [medline] PHST- 2026/01/15 07:55 [pubmed] PHST- 2026/01/15 00:22 [entrez] PHST- 2026/01/14 00:00 [pmc-release] AID - 10.1186/s41043-025-01236-z [pii] AID - 1236 [pii] AID - 10.1186/s41043-025-01236-z [doi] PST - epublish SO - J Health Popul Nutr. 2026 Jan 14;45(1):56. doi: 10.1186/s41043-025-01236-z. PMID- 41535084 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 1 DP - 2026 Jan 14 TI - Protocol for the development of the WHO gestational weight gain charts. PG - e101973 LID - 10.1136/bmjopen-2025-101973 [doi] LID - e101973 AB - INTRODUCTION: Gestational weight gain (GWG) is an important indicator of maternal nutrition to be monitored during pregnancy. However, there is no evidence-based tool that can be used to monitor it across all geographic locations and pre-pregnancy body mass index (BMI) categories. The WHO is undertaking a project to develop GWG charts by pre-pregnancy BMI category, and to identify GWG ranges associated with the lowest risks of adverse maternal and infant outcomes. This protocol describes all the steps that will be used to accomplish the development of these GWG charts. METHODS AND ANALYSIS: This project will involve the analysis of individual participant data (researcher-collected or administrative). To identify eligible datasets with GWG data, a literature review will be conducted and a global call for data will be launched by the WHO. Eligible individual datasets obtained from multiple sources will be harmonised into a pooled database. The database will undergo steps of cleaning, data quality assessment and application of individual-level inclusion criteria. Heterogeneity of maternal weight and GWG will be assessed to verify the possibility of combining datasets from multiple sources and regions into a single database. Generalized Additive Models for Location, Scale and Shape will be applied for the construction of the centile curves. Diagnostic measures, internal and external validation procedures will also be performed. ETHICS AND DISSEMINATION: This project will include an analysis of existing study de-identified data. To be included in the pooled database, each included study should have received ethics approvals from relevant committees. Manuscripts will be submitted to open-access journals and a WHO document will be published, including the GWG charts and cut-offs for application in antenatal care. CI - (c) World Health Organization 2026. Licensee BMJ. FAU - Rangel Bousquet Carrilho, Thais AU - Rangel Bousquet Carrilho T AUID- ORCID: 0000-0001-5928-6136 AD - Department of Obstetrics & Gynaecology, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada thaisrangelnut@gmail.com. FAU - Oladapo, Olufemi Taiwo AU - Oladapo OT AD - UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland. FAU - Hutcheon, Jennifer A AU - Hutcheon JA AD - Department of Obstetrics & Gynaecology, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada. FAU - Gatica-Dominguez, Giovanna AU - Gatica-Dominguez G AD - Nutrition and Food Safety Department, World Health Organization, Geneva, Switzerland. FAU - Rasmussen, Kathleen M AU - Rasmussen KM AD - Division of Nutritional Sciences, Cornell University, Ithaca, New York, USA. FAU - Flores-Urrutia, Monica C AU - Flores-Urrutia MC AD - Nutrition and Food Safety Department, World Health Organization, Geneva, Switzerland. FAU - Kumapley, Richard AU - Kumapley R AD - Nutrition and Food Safety Department, World Health Organization, Geneva, Switzerland. FAU - Tuncalp, Ӧzge AU - Tuncalp Ӧ AUID- ORCID: 0000-0002-5370-682X AD - UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland. FAU - Bahya-Batinda, Dang AU - Bahya-Batinda D AD - Nutrition and Food Safety Department, World Health Organization, Geneva, Switzerland. FAU - Fayed, Amel A AU - Fayed AA AUID- ORCID: 0000-0003-3395-0486 AD - Department of Family and Community Medicine, College of Medicine, Princess Noura Bint AbdulRahman University, Riyadh, Saudi Arabia. FAU - Bogaerts, Annick AU - Bogaerts A AD - REALIFE Research Group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - Faculty of Health, University of Plymouth, Plymouth, UK. FAU - Papageorghiou, Aris T AU - Papageorghiou AT AD - Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK. AD - Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK. FAU - Munoz-Manrique, Cinthya AU - Munoz-Manrique C AD - Nutrition and Bioprogramming Department of the Research Division, National Institute of Perinatology, Mexico City, Mexico. FAU - Farias, Dayana Rodrigues AU - Farias DR AD - Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Josue de Castro Institute of Nutrition, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Ohuma, Eric AU - Ohuma E AUID- ORCID: 0000-0002-3116-2593 AD - Department of Infectious Disease Epidemiology and International Health, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK. FAU - Sachdev, Harshpal AU - Sachdev H AD - Department of Paediatrics, Sitaram Bhartia Institute of Science and Research, New Delhi, New Delhi, India. FAU - Wahabi, Hayfaa A AU - Wahabi HA AD - Department of Family and Community Medicine, Research-chair of Evidence-based Healthcare and Knowledge Translation, College of Medicine, King Saud University, Riyadh, Saudi Arabia. FAU - Teede, Helena J AU - Teede HJ AD - Monash Centre for Health Research and Implementation, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia. FAU - Johansson, Kari AU - Johansson K AD - Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden. AD - Department of Women's Health, Karolinska University Hospital, Stockholm, Sweden. FAU - Bodnar, Lisa M AU - Bodnar LM AD - Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. AD - Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Wang, Molin AU - Wang M AD - Departments of Epidemiology and Biostatistics, Harvard T H Chan School of Public Health, Boston, Massachusetts, USA. AD - Channing Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA. FAU - Perumal, Nandita AU - Perumal N AD - Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, South Carolina, USA. FAU - Hasan, S M Tafsir AU - Hasan SMT AUID- ORCID: 0000-0002-6062-4072 AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh. FAU - Phelan, Suzanne AU - Phelan S AD - Department of Kinesiology and Public Health, Bailey College of Science and Mathematics, California Polytechnic State University, San Luis Obispo, California, USA. FAU - Borghi, Elaine AU - Borghi E AD - Nutrition and Food Safety Department, World Health Organization, Geneva, Switzerland. FAU - Kac, Gilberto AU - Kac G AD - Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Josue de Castro Institute of Nutrition, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. LA - eng GR - 001/WHO_/World Health Organization/International PT - Journal Article DEP - 20260114 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Gestational Weight Gain MH - Pregnancy MH - Female MH - Body Mass Index MH - Research Design MH - Databases, Factual PMC - PMC12815069 OTO - NOTNLM OT - EPIDEMIOLOGY OT - OBSTETRICS OT - Observational Study OT - Pregnancy OT - Pregnant Women COIS- Competing interests: None declared. EDAT- 2026/01/15 16:13 MHDA- 2026/01/15 16:14 PMCR- 2026/01/14 CRDT- 2026/01/14 21:13 PHST- 2026/01/15 16:14 [medline] PHST- 2026/01/15 16:13 [pubmed] PHST- 2026/01/14 21:13 [entrez] PHST- 2026/01/14 00:00 [pmc-release] AID - bmjopen-2025-101973 [pii] AID - 10.1136/bmjopen-2025-101973 [doi] PST - epublish SO - BMJ Open. 2026 Jan 14;16(1):e101973. doi: 10.1136/bmjopen-2025-101973. PMID- 41533053 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20261009 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 2 DP - 2026 Jan 14 TI - PODiaCarD: a prototype of a digital twin platform for the management of pediatric obesity and related cardiometabolic complications. PG - 77 LID - 10.1007/s00431-025-06708-2 [doi] AB - Childhood obesity is the main driver of early metabolic risk, predisposing to cardiovascular disease (CVD) and type 2 diabetes (T2D), which cause millions of deaths worldwide. Their progression is influenced by biological, behavioral, and environmental factors. Digital Twin Systems (DTS) offer innovative ways to monitor and predict cardiometabolic risk. This work presents a prototype digital twin platform called PODiaCarD designed for managing pediatric obesity and related cardiometabolic complications. The system integrates clinical, anthropometric, and lifestyle data with machine learning to estimate outcomes in youth. Built on a three-layer architecture (frontend, backend, predictive engine), PODiaCarD ensures scalability, observability, and reproducibility while enabling continuous model improvement. Models, trained on the PODiaCar project dataset (n = 552, 12.2 +/- 2.9 years) with cross-validation and target-specific algorithms, predict eight key metabolic outcomes. The infrastructure follows privacy-by-design and GDPR standards, ensuring security, auditability, and clinical compliance. PODiaCarD achieved excellent performance for TyG index (F1 = 0.975 +/- 0.014, random forest) and solid results for HbA1C (F1 = 0.844 +/- 0.028, random forest). Moderate accuracy was observed for HOMA (F1 = 0.670 +/- 0.070, Gradient Boosting). In contrast, models for blood pressure (R(2) = 0.05-0.21; F1 = 0.446 +/- 0.045) and glycemia (F1 = 0.113 +/- 0.113) showed poor predictive capacity, while insulin regression (R(2) = 0.211) remained limited, highlighting the need for richer datasets. CONCLUSIONS: PODiaCarD is a promising tool for managing pediatric obesity and complications. It integrates clinical, anthropometric, and behavioral data with ML-based models to support pediatricians in early risk detection, dynamic monitoring, and personalized prevention. Its federated design allows continuous dataset growth and improved predictive performance, strengthening its role in pediatric cardiometabolic care. WHAT IS KNOWN: * Pediatric obesity is a major early driver of cardiometabolic risk; body mass index, waist circumference, and lipid profile are key indicators of insulin resistance, type 2 diabetes, and cardiovascular diseases. Existing pediatric predictive models are often static and limited in longitudinal integration. * Digital Twin Systems enable dynamic monitoring and "what-if" simulations in healthcare, but cardiometabolic applications in pediatric populations remain scarce and insufficiently validated. WHAT IS NEW: * PODiaCarD introduces a federated pediatric digital twin that integrates clinical, anthropometric, and lifestyle data with machine learning to dynamically update individual cardiometabolic risk profiles over time. * The platform achieves strong performance for insulin resistance surrogates and HbA1c prediction, provides explainable AI outputs, ensures privacy-by-design, and supports scalable, multi-centre personalized prevention strategies. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Calcaterra, Valeria AU - Calcaterra V AD - Department of Internal Medicine and Therapeutics, University of Pavia, Viale Golgi n.2, 27100, Pavia, Italy. valeria.calcaterra@unipv.it. AD - Pediatric Department, Buzzi Children's Hospital, 20154, Milano, Italy. valeria.calcaterra@unipv.it. FAU - Ciriello, Umberto AU - Ciriello U AD - Grant & Research Department-LJA-2021, Asomi College of Sciences, 2080, Marsa, Malta. FAU - Medici, Samuele AU - Medici S AD - Grant & Research Department-LJA-2021, Asomi College of Sciences, 2080, Marsa, Malta. FAU - Pagani, Valter AU - Pagani V AD - Grant & Research Department-LJA-2021, Asomi College of Sciences, 2080, Marsa, Malta. FAU - Campoy, Cristina AU - Campoy C AD - Department of Paediatrics, University of Granada, Granada, Spain. AD - Instituto de Investigacion Biosanitaria, IBS_Granada, Granada, 18012, Spain. FAU - Labati, Lucia AU - Labati L AD - Pediatric Department, Buzzi Children's Hospital, 20154, Milano, Italy. AD - Department of Biomedical and Clinical Science, University of Milano, 20157, Milano, Italy. FAU - Rossi, Virginia AU - Rossi V AD - Pediatric Department, Buzzi Children's Hospital, 20154, Milano, Italy. FAU - Escudero-Marin, Mireia AU - Escudero-Marin M AD - Department of Paediatrics, University of Granada, Granada, Spain. FAU - Vandoni, Matteo AU - Vandoni M AD - Laboratory of Adapted Motor Activity (LAMA), Department of Public Health, Experimental Medicine and Forensic Science, University of Pavia, 27100, Pavia, Italy. FAU - Corbellini, Camilo AU - Corbellini C AD - Department of Physiotherapy, LUNEX University of Applied Sciences, Differdange, 4671, Luxembourg. AD - Luxembourg Health & Sport Sciences Research Institute A.s.b.l., 50, Avenue du Parc des Sports, Differdange, 4671, Luxembourg. FAU - Verduci, Elvira AU - Verduci E AD - Pediatric Department, Buzzi Children's Hospital, 20154, Milano, Italy. AD - Department of Health Sciences, University of Milano, 20142, Milano, Italy. FAU - Marin, Luca AU - Marin L AD - Laboratory of Adapted Motor Activity (LAMA), Department of Public Health, Experimental Medicine and Forensic Science, University of Pavia, 27100, Pavia, Italy. AD - Laboratory for Rehabilitation and Orthopedic Surgery (LAROS), Department of Clinical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, 27100, Italy. FAU - Bonillo-Leon, Rocio AU - Bonillo-Leon R AD - Department of Paediatrics, University of Granada, Granada, Spain. FAU - Bahdur, Khatija AU - Bahdur K AD - Luxembourg Health & Sport Sciences Research Institute A.s.b.l., 50, Avenue du Parc des Sports, Differdange, 4671, Luxembourg. AD - Department of Sport and Exercise Science, LUNEX University of Applied Sciences, Differdange, 4671, Luxembourg. FAU - Gatti, Alessandro AU - Gatti A AD - Laboratory of Adapted Motor Activity (LAMA), Department of Public Health, Experimental Medicine and Forensic Science, University of Pavia, 27100, Pavia, Italy. AD - National PhD Programme in One Health approaches to infectious diseases and life science research, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, 27100, Italy. FAU - Fiore, Giulia AU - Fiore G AD - Pediatric Department, Buzzi Children's Hospital, 20154, Milano, Italy. AD - Department of Biomedical and Clinical Science, University of Milano, 20157, Milano, Italy. FAU - Carnevale Pellino, Vittoria AU - Carnevale Pellino V AD - Laboratory of Adapted Motor Activity (LAMA), Department of Public Health, Experimental Medicine and Forensic Science, University of Pavia, 27100, Pavia, Italy. FAU - Mannarino, Savina AU - Mannarino S AD - Pediatric Cardiology Buzzi Children's Hospital, 20154, Milano, Italy. FAU - Zuccotti, Gianvincenzo AU - Zuccotti G AD - Pediatric Department, Buzzi Children's Hospital, 20154, Milano, Italy. AD - Department of Biomedical and Clinical Science, University of Milano, 20157, Milano, Italy. LA - eng PT - Journal Article DEP - 20260114 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Child MH - Digital Health MH - *Pediatric Obesity/therapy/complications/diagnosis MH - *Diabetes Mellitus, Type 2/etiology/prevention & control MH - *Cardiovascular Diseases/etiology/prevention & control MH - Adolescent MH - Female MH - Male MH - Dashboard Systems MH - Reproducibility of Results MH - Machine Learning OTO - NOTNLM OT - Cardiovascular diseases OT - Children OT - Complications OT - Digital twin platform OT - PODiaCar OT - PODiaCarD OT - Pediatric obesity OT - Type 2 diabetes COIS- Declarations. Ethical approval: The study protocol received ethical clearance from the Lombardia 1 Ethics Committee (protocol CET 202-2023). All procedures were conducted in accordance with the principles of the Declaration of Helsinki (1975, revised in 2008). Competing interests: The authors declare no competing interests. EDAT- 2026/01/14 12:31 MHDA- 2026/01/14 12:32 CRDT- 2026/01/14 11:06 PHST- 2025/09/05 00:00 [received] PHST- 2025/12/18 00:00 [accepted] PHST- 2025/12/12 00:00 [revised] PHST- 2026/01/14 12:32 [medline] PHST- 2026/01/14 12:31 [pubmed] PHST- 2026/01/14 11:06 [entrez] AID - 10.1007/s00431-025-06708-2 [pii] AID - 10.1007/s00431-025-06708-2 [doi] PST - epublish SO - Eur J Pediatr. 2026 Jan 14;185(2):77. doi: 10.1007/s00431-025-06708-2. PMID- 41532465 OWN - NLM STAT- MEDLINE DCOM- 20260114 LR - 20260926 IS - 1365-277X (Electronic) IS - 0952-3871 (Print) IS - 0952-3871 (Linking) VI - 39 IP - 1 DP - 2026 Feb TI - Development and Validation of a Food Frequency Questionnaire to Assess Fermented Food Consumption in Adults. PG - e70183 LID - 10.1111/jhn.70183 [doi] LID - e70183 AB - BACKGROUND: Fermented foods can confer benefits to human health and modulate the microbiota-gut-brain axis. Fermented foods are gaining popularity in Western cultures, with increasing calls for their inclusion in national dietary guidelines. As no specific validated measure to capture fermented food intake exists, this study aimed to develop and validate a fermented food intake questionnaire (FFIQ) to assess habitual intake in adults from the United States, Canada, the United Kingdom, Ireland, Australia and New Zealand, aged 18-60 years. METHODS: A 32-item self-administered FFIQ, informed by available international food consumption data for adults, was developed and subsequently validated in an online sample of 167 adults using six online 24-h automated dietary recalls (intake24.com) as the reference method. Correlation and Bland-Altman analyses were used to assess agreement and bias between the FFIQ and the 24-h dietary recalls. RESULTS: The most frequently consumed fermented foods were cheeses, yoghurt, kefir and kombucha. Median (Interquartile range) intake of total fermented food was 85.4 (42.3, 143.0) g/day for the FFIQ and 54.9 (20.8, 112.1) g/day for the average of the 24-h dietary recalls, respectively and showed good agreement for total fermented food consumption (r = 0.56, p < 0.001) and for most individual fermented foods and food categories. The FFIQ classified 93.4% of participants in the same or adjacent tertile of total fermented food intake. Bland-Altman plots for total intake of fermented food demonstrated good agreement between the FFIQ and the 24 h recalls. The FFIQ also showed good to excellent reliability upon re-administration for most fermented foods as indicated by the intraclass correlation coefficients. CONCLUSIONS: The FFIQ provides a robust estimate of fermented food consumption among adults from English-first language countries. This will be a valuable resource with potential applications in clinical and epidemiological research aimed at exploring associations between fermented foods and health outcomes. CI - (c) 2026 The Author(s). Journal of Human Nutrition and Dietetics published by John Wiley & Sons Ltd on behalf of British Dietetic Association. FAU - Ferri, Aimone AU - Ferri A AUID- ORCID: 0009-0001-2156-6092 AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland. FAU - Schneider, Elizabeth AU - Schneider E AUID- ORCID: 0000-0002-1711-0877 AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. FAU - Lucey, Alice AU - Lucey A AD - School of Food and Nutritional Sciences, University College Cork, Cork, Ireland. FAU - Hennessy, Aine AU - Hennessy A AD - School of Food and Nutritional Sciences, University College Cork, Cork, Ireland. AD - INFANT Research Centre, University College Cork, Cork, Ireland. FAU - Cotter, Paul D AU - Cotter PD AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - Food Biosciences Department, Teagasc Food Research Centre, Cork, Ireland. FAU - Balasubramanian, Ramya AU - Balasubramanian R AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland. AD - Food Biosciences Department, Teagasc Food Research Centre, Cork, Ireland. FAU - Clarke, Gerard AU - Clarke G AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland. FAU - Cryan, John F AU - Cryan JF AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland. LA - eng GR - SFI/12/RC/2273_P2/Science Foundation Ireland grant to APC Microbiome Ireland through the Irish Government's National Development Plan/ PT - Journal Article PT - Validation Study PL - England TA - J Hum Nutr Diet JT - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JID - 8904840 SB - IM MH - Humans MH - Adult MH - Female MH - Male MH - Middle Aged MH - Young Adult MH - Surveys and Questionnaires/standards MH - Adolescent MH - *Fermented Foods/statistics & numerical data MH - Reproducibility of Results MH - *Diet/statistics & numerical data MH - Mental Recall MH - Australia MH - *Diet Surveys/methods MH - United Kingdom MH - *Feeding Behavior MH - New Zealand MH - United States MH - Ireland MH - Canada PMC - PMC12801178 OTO - NOTNLM OT - fermentation OT - food frequency questionnaire OT - gut health OT - kefir OT - kombucha OT - microbiome OT - microbiota COIS- E.S. has received honorarium from Janssen Sciences Ireland UC. E.S. also received an honorarium from MyNutriWeb for an event that was sponsored by Yakult. The laboratory directed by P.D.C. has received research funding from FrieslandCampina, PrecisionBiotics Group, PepsiCo and Danone. P.D.C. has also received support from PepsiCo, Arla, Danone, Yakult, AG1 and H&H to attend and speak at scientific conferences and other events. In addition, P.D.C. is a co-founder and serves as Head of Microbiology of SeqBiome. G.C. has received honoraria from Janssen, Probi, Apsen and Ingelheim Boehringer as an invited speaker; is in receipt of research funding from Pharmavite, Fonterra, Reckitt, Nestle and Tate and Lyle; and has been paid for consultancy work by Yakult, Zentiva, Bayer Healthcare and Heel Pharmaceuticals. J.F.C. has been an invited speaker at conferences organised by Bromotech, Yakult, Nutricia and Nestle and has received research funding from Kerry Foods, DuPont/IFF and Nestle. The other authors declare no conflicts of interest. EDAT- 2026/01/14 12:30 MHDA- 2026/01/14 12:31 PMCR- 2026/01/14 CRDT- 2026/01/14 06:13 PHST- 2025/11/25 00:00 [revised] PHST- 2025/08/27 00:00 [received] PHST- 2025/12/12 00:00 [accepted] PHST- 2026/01/14 12:31 [medline] PHST- 2026/01/14 12:30 [pubmed] PHST- 2026/01/14 06:13 [entrez] PHST- 2026/01/14 00:00 [pmc-release] AID - JHN70183 [pii] AID - 10.1111/jhn.70183 [doi] PST - ppublish SO - J Hum Nutr Diet. 2026 Feb;39(1):e70183. doi: 10.1111/jhn.70183. PMID- 41528779 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1461-7277 (Electronic) IS - 1359-1053 (Print) IS - 1359-1053 (Linking) VI - 31 IP - 9 DP - 2026 Aug TI - Is mindful screen time a resilience factor for screen-related experiences of psychological needs and well-being? PG - 3709-3726 LID - 10.1177/13591053251398259 [doi] AB - We examined the measurement of mindful screen time and whether it moderated links between screen-related psychological needs (satisfaction and frustration) and well-being. University students (N = 770, M(age) = 19.96) completed a questionnaire online. A unidimensional structure of mindful screen time had an adequate fit (CFI = 0.97, RMSEA = 0.08) and composite reliability (0.79). Correlations between mindful screen time and well-being (rs = |0.08-0.26|) showed evidence of validity based on relations to other variables. Path analysis indicated two of the eight moderated associations were statistically significant but counter to hypotheses: higher mindful screen time increased the negative influence of need frustration on negative affect and diminished the positive influence of need satisfaction on flourishing. Screen-related psychological need satisfaction and frustration were key factors influencing well-being. Effect sizes were small-to-moderate (R(2) = 0.21-0.48). Overall, we found that that mindful screen time is not a robust moderator. More research is needed to better understand the role of mindful screen time on well-being. FAU - Gunnell, Katie E AU - Gunnell KE AUID- ORCID: 0000-0002-8729-6486 AD - Carleton University, Ottawa, ON, Canada. FAU - Salmon, Mackenzie AU - Salmon M AD - Carleton University, Ottawa, ON, Canada. FAU - Yung, Jayson J AU - Yung JJ AD - Carleton University, Ottawa, ON, Canada. FAU - Liu, Yan AU - Liu Y AUID- ORCID: 0000-0003-3778-1325 AD - Carleton University, Ottawa, ON, Canada. FAU - Goldfield, Gary S AU - Goldfield GS AD - Carleton University, Ottawa, ON, Canada. AD - The Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260113 PL - England TA - J Health Psychol JT - Journal of health psychology JID - 9703616 SB - IM MH - Humans MH - Psychological Well-Being MH - Female MH - *Screen Time MH - Young Adult MH - Male MH - *Mindfulness MH - *Resilience, Psychological MH - Students/psychology MH - Surveys and Questionnaires MH - Adolescent MH - *Personal Satisfaction MH - Reproducibility of Results MH - Adult PMC - PMC13365308 OTO - NOTNLM OT - adolescents OT - mental health OT - self-determination theory OT - smartphone OT - social media OT - young adults COIS- Declaration of conflicting interestsDr. Goldfield reports a relationship with ongoing social media litigation efforts that includes: paid consulting or Advisory. The other authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/01/13 13:15 MHDA- 2026/07/14 14:01 PMCR- 2026/07/14 CRDT- 2026/01/13 11:53 PHST- 2026/07/14 14:01 [medline] PHST- 2026/01/13 13:15 [pubmed] PHST- 2026/01/13 11:53 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - 10.1177_13591053251398259 [pii] AID - 10.1177/13591053251398259 [doi] PST - ppublish SO - J Health Psychol. 2026 Aug;31(9):3709-3726. doi: 10.1177/13591053251398259. Epub 2026 Jan 13. PMID- 41528475 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 1432-1084 (Electronic) IS - 0938-7994 (Print) IS - 0938-7994 (Linking) VI - 36 IP - 6 DP - 2026 Jun TI - Deep learning-based automatic measurement of the femoral head ossification center in healthy Korean children: development of a novel radiographic growth chart. PG - 4989-4999 LID - 10.1007/s00330-025-12263-z [doi] AB - OBJECTIVES: To develop and validate a deep learning (DL)-based algorithm for automated measurement of femoral head ossification center (FHOC) size and establish AI-derived growth charts. MATERIALS AND METHODS: This retrospective study included 1705 healthy Korean children (mean age, 5.1 +/- 3.3 years; 841 females, 864 males) with anteroposterior pelvic radiographs (2018-2024). A three-stage DL algorithm (region-of-interest detection, FHOC segmentation, landmark-based size computation) was used to automatically measure FHOC size. Agreement with radiologist measurements was evaluated using concordance correlation coefficient (CCC), Pearson correlation coefficient (r), mean absolute error (MAE), root mean square error (RMSE), and Bland-Altman analyses, supplemented by paired t-test and Fisher's Z-test. AI measurements were used to create FHOC growth charts via quantile polynomial regression, with predictive accuracy assessed by adjusted R(2), MAE, and RMSE. RESULTS: AI-derived FHOC size measurements showed close agreement with radiologist measurements, with mean differences within +/-0.5 mm and 95% limits of agreement within +/-3 mm in age-stratified analyses, and overall agreement was further supported by high CCC, r, and consistently low error metrics. Growth curves based on AI measurements demonstrated strong predictive accuracy (adjusted R(2) = 0.927 for females; 0.934 for males), with low errors across age groups (females: MAE 1.77-2.98 mm, RMSE 2.28-3.54 mm; males: MAE 1.60-3.01 mm, RMSE 2.00-4.10 mm). Reference percentiles (5th-95th) were established, providing standardized FHOC size ranges for clinical application. CONCLUSION: Our DL-based approach provides precise and reproducible FHOC size measurement, offering a robust reference for standardized growth assessment and early pediatric hip joint evaluation. KEY POINTS: QuestionThe timing of FHOC appearance is an important radiographic indicator; however, manual measurement is subjective, and studies on age-specific changes remain limited. FindingsA DL-based algorithm achieved high agreement with expert measurements, and age-based regression reliably predicted FHOC size in children. Clinical relevanceAI-derived FHOC growth charts may provide objective, standardized references for pediatric hip joint development, potentially enabling earlier detection of growth abnormalities and improving diagnostic consistency in clinical practice. CI - (c) 2025. The Author(s). FAU - Lee, Byoung-Dai AU - Lee BD AD - Department of Computer Science, Graduate School, Kyonggi University, Suwon-si, Republic of Korea. FAU - Moon, Ki-Ryum AU - Moon KR AD - Department of Computer Science, Graduate School, Kyonggi University, Suwon-si, Republic of Korea. FAU - Kim, Jin Young AU - Kim JY AD - Department of Radiology, Keimyung University Dongsan Hospital, Daegu, Republic of Korea. FAU - Lee, Mu Sook AU - Lee MS AUID- ORCID: 0000-0002-0382-5564 AD - Department of Radiology, Keimyung University Dongsan Hospital, Daegu, Republic of Korea. musukilee@kmu.ac.kr. LA - eng GR - NRF-2022R1A2C1007169/National Research Foundation of Korea/ GR - RS-2020-NR049579/National Research Foundation of Korea/ PT - Journal Article DEP - 20260113 PL - Germany TA - Eur Radiol JT - European radiology JID - 9114774 SB - IM MH - Humans MH - Female MH - Male MH - Child, Preschool MH - *Deep Learning MH - Republic of Korea MH - Retrospective Studies MH - *Growth Charts MH - Child MH - *Femur Head/diagnostic imaging/growth & development MH - Algorithms MH - *Osteogenesis/physiology MH - Reference Values MH - Infant MH - Radiography/methods MH - Reproducibility of Results PMC - PMC13212369 OTO - NOTNLM OT - Artificial intelligence OT - Child development OT - Femur head OT - Growth charts OT - Radiography COIS- Compliance with ethical standards. Guarantor: The scientific guarantor of this publication is Mu Sook Lee. Conflict of interest: The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. Statistics and biometry: All of the authors have significant statistical expertise. Informed consent: Written informed consent was waived by the Institutional Review Board due to the retrospective nature of the study and use of de-identified, pre-existing clinical data. Ethical approval: The Institutional Review Board of Keimyung University Dongsan Medical Center approved this retrospective study (IRB No. DSM-2022-08-007). All methods were performed in accordance with the ethical standards of the Helsinki Declaration. Study subjects or cohorts overlap: None of the study subjects or cohorts has been previously reported. Methodology: Retrospective Observational Performed at one institution EDAT- 2026/01/13 13:15 MHDA- 2026/05/27 06:34 PMCR- 2026/01/13 CRDT- 2026/01/13 11:14 PHST- 2025/05/13 00:00 [received] PHST- 2025/12/07 00:00 [accepted] PHST- 2025/11/29 00:00 [revised] PHST- 2026/05/27 06:34 [medline] PHST- 2026/01/13 13:15 [pubmed] PHST- 2026/01/13 11:14 [entrez] PHST- 2026/01/13 00:00 [pmc-release] AID - 10.1007/s00330-025-12263-z [pii] AID - 12263 [pii] AID - 10.1007/s00330-025-12263-z [doi] PST - ppublish SO - Eur Radiol. 2026 Jun;36(6):4989-4999. doi: 10.1007/s00330-025-12263-z. Epub 2026 Jan 13. PMID- 41526955 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260721 IS - 1472-6874 (Electronic) IS - 1472-6874 (Linking) VI - 26 IP - 1 DP - 2026 Jan 13 TI - A relationship study of factors associated with emotional eating in women in Turkiye: body mass index, premenstrual syndrome, eating behavior, and quality of life. PG - 85 LID - 10.1186/s12905-026-04270-z [doi] LID - 85 AB - BACKGROUND: Obesity and premenstrual syndrome (PMS) are associated with hormonal and psychosocial factors that affect emotional appetite and eating behaviors in women. In a sample of Turkish women, evidence regarding the relationships between body mass index (BMI), PMS symptoms, eating behaviors, quality of life, and emotional appetite is limited. This study was conducted to examine the relationships between emotional eating and BMI, PMS, eating behaviors, and quality of life among women in Turkey and to assess the relative contributions of these factors to emotional eating. METHODS: This cross-sectional study, conducted online in Turkiye between April 1 and May 1, 2025, included 450 women aged 18-49 years. Data were collected using snowball sampling with validated and reliable scales for PMS, emotional appetite, eating behavior, and PMS-specific quality of life. Four-block hierarchical regression analysis (IBM SPSS 27.0) was performed to assess the contributions of BMI, PMS subscales, eating behaviors, and quality of life, respectively, with a significance level of p < 0.05. RESULTS: Most participants were single (63.8%), had a bachelor's degree (66.4%), and had regular menstrual cycles (88.4%). Depressive mood and fatigue had the highest mean scores on the PSAS subscales. A positive correlation was found between emotional appetite and BMI (r = 0.386), PMS appetite changes (r = 0.277), and emotional undereating (r = 0.439); a strong negative correlation was found with emotional overeating (r = - 0.641). In hierarchical regression analysis, emotional overeating emerged as the strongest predictor of emotional appetite (beta = -0.523). BMI and PMS-induced appetite changes showed their explanatory effects more prominently in the earlier model steps. The final model explained 51.3% of the variance in emotional appetite (Adjusted R(2) = 0.513). CONCLUSIONS: The findings support a multidimensional perspective on premenstrual distress, revealing significant links between BMI, emotional appetite, and PMS symptom severity. Specifically, emotional overeating and undereating emerged as strong behavioral predictors, while hierarchical models confirmed that these factors collectively explain significant incremental variance in symptom burden. These results underscore the need for integrated interventions that address the biological (e.g., weight status), psychological (e.g., affective symptoms), and behavioral (e.g., emotion-driven eating) dimensions underlying this relationship. FAU - Ozcanarslan, Neslihan AU - Ozcanarslan N AUID- ORCID: 0000-0002-3613-6319 AD - Department of Public Health Nursing, Faculty of Health Sciences, Toros University, Mersin, 33140, Turkiye. neslihan.ozcanarslan@toros.edu.tr. FAU - Ozpak Akkus, Ozlem AU - Ozpak Akkus O AUID- ORCID: 0000-0002-1471-8000 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Toros University, Mersin, Turkiye. LA - eng PT - Journal Article DEP - 20260113 PL - England TA - BMC Womens Health JT - BMC women's health JID - 101088690 SB - IM MH - Humans MH - Female MH - *Quality of Life/psychology MH - Adult MH - *Emotional Eating/psychology MH - *Premenstrual Syndrome/psychology/epidemiology MH - *Body Mass Index MH - Cross-Sectional Studies MH - Middle Aged MH - Young Adult MH - Adolescent MH - *Feeding Behavior/psychology MH - Turkey/epidemiology MH - Surveys and Questionnaires MH - Obesity/psychology MH - Emotions PMC - PMC12888315 OTO - NOTNLM OT - Appetite OT - Body mass index OT - Eating behavior OT - Emotional eating OT - Premenstrual syndrome OT - Quality of life COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the ethical principles of the Declaration of Helsinki. This study was approved by the Toros University Scientific Research and Publication Ethics Committee (Protocol No: 51, Approval Date: March 23, 2025). The informed consent process was conducted via an online survey platform (Google Forms). At the beginning of the survey, participants were presented with a comprehensive information text about the purpose of the study, the expected duration, risks and benefits, the anonymity and confidentiality of the data, the fact that participation was entirely voluntary, and the right to withdraw at any time. To confirm that they had read and agreed to this information, they were required to check a box indicating 'I agree' before continuing with the survey. Only participants who checked this box were able to access the survey questions. This method is a standard electronic informed consent procedure approved by the ethics committee. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/13 00:25 MHDA- 2026/06/28 13:04 PMCR- 2026/01/13 CRDT- 2026/01/12 23:54 PHST- 2025/11/10 00:00 [received] PHST- 2026/01/06 00:00 [accepted] PHST- 2026/06/28 13:04 [medline] PHST- 2026/01/13 00:25 [pubmed] PHST- 2026/01/12 23:54 [entrez] PHST- 2026/01/13 00:00 [pmc-release] AID - 10.1186/s12905-026-04270-z [pii] AID - 4270 [pii] AID - 10.1186/s12905-026-04270-z [doi] PST - epublish SO - BMC Womens Health. 2026 Jan 13;26(1):85. doi: 10.1186/s12905-026-04270-z. PMID- 41526856 OWN - NLM STAT- MEDLINE DCOM- 20260602 LR - 20260706 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jan 13 TI - "Predictors of failed vaginal birth after cesarean and associated maternal and neonatal outcomes: a case control study". PG - 145 LID - 10.1186/s12884-025-08594-w [doi] LID - 145 AB - BACKGROUND: Vaginal Birth After Cesarean is a clinical measure that can reduce repeated cesarean deliveries, improve perinatal outcomes and shorten hospital stays. However, successful practice of Vaginal Birth After Cesarean remains restricted in the Middle East due to limited regional-specific guidelines. This study aimed to identify the predictors and maternal and neonatal outcomes of failed Vaginal Birth After Cesarean among a group of Middle Eastern women. METHODS: A retrospective case-control design was conducted between January 2023 and February 2024 across three hospitals in Oman. The case group involved failed Vaginal Birth After Cesarean requiring repeat cesarean, while the control group comprised successful Vaginal Birth After Cesarean. Descriptive and inferential statistics were used. Additionally, logistic regression analysis was conducted to identify significant predictors of failed vaginal birth after cesarean. RESULTS: Data of 364 participants were analyzed. The predictors of Vaginal Birth After Cesarean failure were high body mass index (32.66 +/- 7.53; p < .001), low parity (median = 1; p < .001), low cervical dilation (2 cm vs. 4 cm; p < .001), obstetric complications (42.6% vs. 29.2%; p = .010), and meconium-stained amniotic fluid (16.3% vs. 6.9%; p = .006). Postpartum hemorrhage (21.6% vs. 4.6%; p < .001), scar tenderness (11.5% vs. 0.5%; p < .001), and low APGAR scores (p < .001) were more common in the case group. CONCLUSIONS: The study findings advance the regional literature with critical information supporting the development of standardized Middle Eastern specific Vaginal Birth After Cesarean guidelines. Higher body mass index, lower parity, lower cervical dilation at admission, meconium-stained amniotic fluid, and obstetric complications are significant predictors of Vaginal Birth After Cesarean failure. A failed Vaginal Birth After Cesarean attempt may increase the risks of post-partum hemorrhage, scar tenderness, and lower APGAR scores. Future research may prioritize prospective multicenter studies across diverse regions of the Middle East to validate the Vaginal Birth After Cesarean predictive variables. CI - (c) 2026. The Author(s). FAU - Al Rashdia, Asila AU - Al Rashdia A AD - Maternal and Child Health Department, College of Nursing, Sultan Qaboos University, Al Khod 66, Muscat, 123, Oman. AD - Delivery Ward, Sultan Qaboos University Hospital, Muscat, Oman. FAU - Al Yazeedi, Basma AU - Al Yazeedi B AD - Maternal and Child Health Department, College of Nursing, Sultan Qaboos University, Al Khod 66, Muscat, 123, Oman. basma84@squ.edu.om. FAU - Al Hashmi, Iman AU - Al Hashmi I AD - Maternal and Child Health Department, College of Nursing, Sultan Qaboos University, Al Khod 66, Muscat, 123, Oman. FAU - Al Azri, Zeinab AU - Al Azri Z AD - Maternal and Child Health Department, College of Nursing, Sultan Qaboos University, Al Khod 66, Muscat, 123, Oman. LA - eng GR - RC/GRG/CON/M&C/24/112/Ministry of Higher Education, Research and Innovation/ PT - Journal Article DEP - 20260113 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Adult MH - Female MH - Humans MH - Infant, Newborn MH - Pregnancy MH - Case-Control Studies MH - Cesarean Section, Repeat/statistics & numerical data MH - Oman/epidemiology MH - Parity MH - Pregnancy Outcome MH - Retrospective Studies MH - Risk Factors MH - *Vaginal Birth after Cesarean/statistics & numerical data/adverse effects PMC - PMC12888156 OTO - NOTNLM OT - Cesarean section OT - Maternal outcomes OT - Neonatal outcomes OT - Oman OT - Trial of labor after cesarean OT - Vaginal birth after cesarean COIS- Declarations. Ethics approval and consent to participate: The researchers obtained ethical approvals from the Research and Ethics Committee at the College of Nursing in Sultan Qaboos University (CON/MSN/2024/5) and the Health Studies and Research Approval Committee at the Ministry of Health (MOH/CSR/24/28414), Oman. Due to the nature of the retrospective design of the study, informed consent was waived. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/13 00:25 MHDA- 2026/02/10 06:31 PMCR- 2026/01/13 CRDT- 2026/01/12 23:46 PHST- 2025/10/07 00:00 [received] PHST- 2025/12/12 00:00 [accepted] PHST- 2026/02/10 06:31 [medline] PHST- 2026/01/13 00:25 [pubmed] PHST- 2026/01/12 23:46 [entrez] PHST- 2026/01/13 00:00 [pmc-release] AID - 10.1186/s12884-025-08594-w [pii] AID - 8594 [pii] AID - 10.1186/s12884-025-08594-w [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jan 13;26(1):145. doi: 10.1186/s12884-025-08594-w. PMID- 41525344 OWN - NLM STAT- MEDLINE DCOM- 20260112 LR - 20260115 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 1 DP - 2026 TI - ACMTF-R: Supervised multi-omics data integration uncovering shared and distinct outcome-associated variation. PG - e0339650 LID - 10.1371/journal.pone.0339650 [doi] LID - e0339650 AB - The rapid growth of high-dimensional biological data has necessitated advanced data fusion techniques to integrate and interpret complex multi-omics and longitudinal datasets. Shared and unshared structure across such datasets can be identified in an unsupervised manner with Advanced Coupled Matrix and Tensor Factorization (ACMTF), but this cannot be related to an outcome. Conversely, N-way Partial Least Squares (NPLS) is supervised and captures outcome-associated variation but cannot identify shared and unshared structure. To bridge the gap between data exploration and prediction, we introduce ACMTF-Regression (ACMTF-R), an extension of ACMTF that incorporates a regression step, allowing for the simultaneous decomposition of multi-way data while explicitly capturing variation associated with a dependent variable. We present a detailed mathematical formulation of ACMTF-R, including its optimisation algorithm and implementation. Through extensive simulations, we systematically evaluate its ability to recover a small [Formula: see text]-related component shared between multiple blocks, its robustness to noise, and the impact of the tuning parameter ([Formula: see text]) which controls the balance between data exploration and outcome prediction. Our results demonstrate that ACMTF-R can robustly identify the [Formula: see text]-related component, correctly identifying outcome-associated shared and distinct variation, distinguishing it from existing approaches such as NPLS and ACMTF. The development of ACMTF-R was motivated by a real-world dataset investigating how maternal pre-pregnancy BMI affects the human milk microbiome, human milk metabolome, and infant faecal microbiome. Emerging evidence suggests that inter-generational transfer of maternal obesity may affect multiple omics layers, highlighting the need to identify outcome-associated variation. The applicability of ACMTF-R is therefore validated by applying it to this multi-omics dataset. ACMTF-R successfully identifies novel mother-infant relationships associated with maternal pre-pregnancy BMI, underscoring its utility in multi-omics research. Our findings establish ACMTF-R as a versatile tool for multi-way data fusion, offering new insights into complex biological systems by integrating common, local, and distinct variation in the context of a dependent variable. CI - Copyright: (c) 2026 van der Ploeg et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - van der Ploeg, Geert Roelof AU - van der Ploeg GR AUID- ORCID: 0009-0007-5204-3386 AD - Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands. FAU - White, Fred T G AU - White FTG AUID- ORCID: 0000-0003-0434-6028 AD - Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands. FAU - Jakobsen, Rasmus Riemer AU - Jakobsen RR AD - Department of Food Science, University of Copenhagen, Rolighedsvej, Frederiksberg C, Denmark. FAU - Westerhuis, Johan A AU - Westerhuis JA AD - Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands. FAU - Heintz-Buschart, Anna AU - Heintz-Buschart A AUID- ORCID: 0000-0002-9780-1933 AD - Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands. FAU - Smilde, Age K AU - Smilde AK AD - Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands. LA - eng PT - Journal Article DEP - 20260112 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Female MH - Humans MH - Pregnancy MH - Algorithms MH - Metabolomics/methods MH - Milk, Human/microbiology/metabolism MH - *Multiomics MH - Feces/microbiology MH - Infant PMC - PMC12795394 COIS- The authors have declared that no competing interests exist. EDAT- 2026/01/12 19:24 MHDA- 2026/01/12 19:25 PMCR- 2026/01/12 CRDT- 2026/01/12 13:46 PHST- 2025/09/04 00:00 [received] PHST- 2025/12/09 00:00 [accepted] PHST- 2026/01/12 19:25 [medline] PHST- 2026/01/12 19:24 [pubmed] PHST- 2026/01/12 13:46 [entrez] PHST- 2026/01/12 00:00 [pmc-release] AID - PONE-D-25-48000 [pii] AID - 10.1371/journal.pone.0339650 [doi] PST - epublish SO - PLoS One. 2026 Jan 12;21(1):e0339650. doi: 10.1371/journal.pone.0339650. eCollection 2026. PMID- 41523078 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260112 LR - 20260114 IS - 0976-4879 (Print) IS - 0975-7406 (Electronic) IS - 0975-7406 (Linking) VI - 17 IP - Suppl 4 DP - 2025 Dec TI - Oral Hygiene Neglect in Indian Teens and Young Adults Due to Depression Caused by Internet Addiction. PG - S3063-S3065 LID - 10.4103/jpbs.jpbs_1076_25 [doi] AB - BACKGROUND: Internet addiction is increasingly prevalent among adolescents and young adults, contributing to mental health issues and self-care neglect, including oral hygiene. AIM: To assess the correlation between internet addiction-induced depression and oral hygiene neglect among Indian youth. METHODS: A cross-sectional survey was conducted among 382 university students aged 17-25 using a validated online questionnaire. Data were analyzed using Chi-square tests. RESULTS: Significant associations were found between high screen time, depressive symptoms (P = 0.001), and reduced brushing frequency (P = 0.015). CONCLUSION: Internet addiction is linked to depression and neglect of oral hygiene in young adults. CI - Copyright: (c) 2025 Journal of Pharmacy and Bioallied Sciences. FAU - Pandey, Shreyansh AU - Pandey S AD - Manav Rachna Dental College, Faridabad, Haryana, India. FAU - Srivastava, Madhulika AU - Srivastava M AD - Department of Pediatric and Preventive Dentistry, Manav Rachna Dental College, Faridabad, Haryana, India. FAU - Bansal, Savita AU - Bansal S AD - Department of General Pathology, Manav Rachna Dental College, SDS, MRIIRS, Faridabad, Haryana, India. FAU - Goswami, Harsita AU - Goswami H AD - Manav Rachna Dental College, Faridabad, Haryana, India. FAU - Jain, Vikram Sain AU - Jain VS AD - Manav Rachna Dental College, Faridabad, Haryana, India. FAU - Baisoya, Nitik AU - Baisoya N AD - Manav Rachna Dental College, Faridabad, Haryana, India. LA - eng PT - Journal Article DEP - 20251217 PL - India TA - J Pharm Bioallied Sci JT - Journal of pharmacy & bioallied sciences JID - 101537209 PMC - PMC12788475 OTO - NOTNLM OT - Depression OT - internet addiction OT - oral hygiene neglect COIS- There are no conflicts of interest. EDAT- 2026/01/12 06:29 MHDA- 2026/01/12 06:30 PMCR- 2025/12/01 CRDT- 2026/01/12 05:42 PHST- 2025/06/15 00:00 [received] PHST- 2025/06/16 00:00 [revised] PHST- 2025/07/18 00:00 [accepted] PHST- 2026/01/12 06:30 [medline] PHST- 2026/01/12 06:29 [pubmed] PHST- 2026/01/12 05:42 [entrez] PHST- 2025/12/01 00:00 [pmc-release] AID - JPBS-17-3063 [pii] AID - 10.4103/jpbs.jpbs_1076_25 [doi] PST - ppublish SO - J Pharm Bioallied Sci. 2025 Dec;17(Suppl 4):S3063-S3065. doi: 10.4103/jpbs.jpbs_1076_25. Epub 2025 Dec 17. PMID- 41517396 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260110 LR - 20260113 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 1 DP - 2025 Dec 24 TI - Development of Novel Predictive Scores for Obstetrical Risk Stratification in Adolescent Pregnancies: A Retrospective Study. LID - 10.3390/jcm15010139 [doi] LID - 139 AB - Background: Adolescent pregnancies represent a significant global health challenge, with increased risks of maternal and neonatal complications. Traditional obstetrical risk assessment tools have limited applicability in this population due to unique physiological and anatomical characteristics. This study aimed to develop and validate novel predictive scores specifically designed for obstetrical risk stratification in adolescent pregnancies. Methods: A retrospective study was conducted over seven years (2018-2024) in Brasov County, Romania, including 1322 adolescent pregnancies (ages 12-16 years). Two novel predictive scores were developed: the Cervical Ripening Ultrasound Index (CRUI) for predicting successful vaginal delivery and labor induction, and the ADOLESRISK score for comprehensive obstetrical risk stratification. Statistical analysis included logistic regression, ROC curve analysis, and validation testing using SPSS 26.0 and R Studio version 4.3.2. Results: The CRUI score demonstrated superior predictive performance (AUC = 0.87, 95% CI: 0.84-0.90) compared to traditional Bishop score (AUC = 0.62, 95% CI: 0.58-0.66) for successful labor induction in adolescents. The ADOLESRISK score achieved 84% sensitivity and 76% specificity for predicting major obstetrical complications, significantly outperforming conventional risk assessment tools. Key risk factors incorporated included maternal age, educational level, nutritional status, and specific ultrasound parameters. Internal validation using train-test split methodology (70-30%) confirmed robust performance in the independent validation cohort (n = 397), with maintained discriminative ability (CRUI: AUC = 0.85, 95% CI: 0.80-0.90; ADOLESRISK: AUC = 0.82, 95% CI: 0.77-0.87) across different demographic subgroups. Conclusions: The CRUI and ADOLESRISK scores represent significant advances in adolescent obstetrical care, providing clinicians with tools for personalized risk assessment and management. Implementation of these scores could potentially reduce maternal complications by 25-30% and improve neonatal outcomes by 20-25%, representing a major contribution to adolescent reproductive health globally. FAU - Khudor, Abdul Jabar AU - Khudor AJ AD - Medicine PhD School, Transilvania University of Brasov, 500036 Brasov, Romania. FAU - Moga, Marius Alexandru AU - Moga MA AUID- ORCID: 0000-0002-2442-6917 AD - Faculty of Medicine, Transilvania University of Brasov, 500036 Brasov, Romania. FAU - Dimienescu, Oana Gabriela AU - Dimienescu OG AUID- ORCID: 0000-0001-9407-389X AD - Faculty of Medicine, Transilvania University of Brasov, 500036 Brasov, Romania. FAU - Nicolau, Andrada Camelia AU - Nicolau AC AD - Faculty of Medicine, Transilvania University of Brasov, 500036 Brasov, Romania. FAU - Arvatescu, Cristian Andrei AU - Arvatescu CA AD - Faculty of Medicine, Transilvania University of Brasov, 500036 Brasov, Romania. FAU - Hogea, Mircea Daniel AU - Hogea MD AUID- ORCID: 0000-0001-7586-7205 AD - Faculty of Medicine, Transilvania University of Brasov, 500036 Brasov, Romania. LA - eng PT - Journal Article DEP - 20251224 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC12786813 OTO - NOTNLM OT - ADOLESRISK OT - CRUI OT - adolescent pregnancy OT - cervical ripening OT - obstetrical risk OT - predictive scores OT - pregnancy complications OT - risk stratification COIS- The authors declare no conflicts of interest. EDAT- 2026/01/10 06:31 MHDA- 2026/01/10 06:32 PMCR- 2025/12/24 CRDT- 2026/01/10 01:15 PHST- 2025/11/17 00:00 [received] PHST- 2025/12/17 00:00 [revised] PHST- 2025/12/19 00:00 [accepted] PHST- 2026/01/10 06:32 [medline] PHST- 2026/01/10 06:31 [pubmed] PHST- 2026/01/10 01:15 [entrez] PHST- 2025/12/24 00:00 [pmc-release] AID - jcm15010139 [pii] AID - jcm-15-00139 [pii] AID - 10.3390/jcm15010139 [doi] PST - epublish SO - J Clin Med. 2025 Dec 24;15(1):139. doi: 10.3390/jcm15010139. PMID- 41517013 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260110 LR - 20260926 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 1 DP - 2025 Dec 30 TI - Adapted Judo as a Multidimensional Intervention: Effects on Physical Fitness and Psychosocial Well-Being in Adolescents with Down Syndrome. LID - 10.3390/healthcare14010081 [doi] LID - 81 AB - Background/Objectives: Adolescents with Down syndrome often present limitations in physical fitness and psychosocial well-being, which can affect their health and social inclusion. Adapted physical activity programs, such as martial arts, may offer multidimensional benefits. This study aimed to analyze the effects of an adapted judo intervention on physical fitness and psychosocial outcomes in adolescents with Down syndrome. Methods: A quasi-experimental design was applied with 43 adolescents diagnosed with Down syndrome, allocated to a control group (n = 19) and an intervention group (n = 24). Participants in the intervention group completed a 24-week adapted judo program. Physical fitness was assessed through standardized tests for strength, balance, and flexibility, while psychosocial well-being was evaluated using validated questionnaires on self-esteem and social interaction. Pre- and post-intervention comparisons were conducted using appropriate statistical analyses. Results: Participants showed significant improvements in physical fitness components, particularly in muscular strength and balance (p < 0.05). Flexibility also increased, although to a lesser extent. Psychosocial measures revealed enhanced self-esteem and greater perceived social interaction, indicating positive effects beyond physical health. Conclusions: Adapted judo appears to be an effective multidimensional intervention for adolescents with Down syndrome, promoting both physical and psychosocial benefits. These findings support the inclusion of adapted martial arts in physical education and therapeutic programs aimed at fostering health and social participation in this population. FAU - Suarez-Villadat, Borja AU - Suarez-Villadat B AUID- ORCID: 0000-0003-1574-868X AD - Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Health Sciences Faculty, Universidad Rey Juan Carlos, 28922 Madrid, Spain. FAU - Montero, Mario AU - Montero M AD - Faculty of Sport Science, Pablo Olavide University, 41013 Sevilla, Spain. AD - Faculty of Biomedical and Health Sciences, Alfonso X el Sabio University, 28691 Madrid, Spain. FAU - Montero, Sonia AU - Montero S AD - Faculty of Sport Science, Pablo Olavide University, 41013 Sevilla, Spain. AD - Faculty of Biomedical and Health Sciences, Alfonso X el Sabio University, 28691 Madrid, Spain. FAU - Lopez-Garcia, Adrian AU - Lopez-Garcia A AUID- ORCID: 0009-0004-2686-3944 AD - Sport Sciences Research Centre, Universidad Rey Juan Carlos, 28942 Madrid, Spain. FAU - Villagra, Ariel AU - Villagra A AUID- ORCID: 0000-0003-3666-5453 AD - Department of Physical Education, Sport and Human Movement, Autonomous University of Madrid, 28049 Madrid, Spain. LA - eng PT - Journal Article DEP - 20251230 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12785297 OTO - NOTNLM OT - Down syndrome OT - adapted judo OT - inclusive physical activity OT - physical fitness OT - psychosocial well-being COIS- The authors declare no conflicts of interest. EDAT- 2026/01/10 06:31 MHDA- 2026/01/10 06:32 PMCR- 2025/12/30 CRDT- 2026/01/10 01:13 PHST- 2025/11/18 00:00 [received] PHST- 2025/12/07 00:00 [revised] PHST- 2025/12/26 00:00 [accepted] PHST- 2026/01/10 06:32 [medline] PHST- 2026/01/10 06:31 [pubmed] PHST- 2026/01/10 01:13 [entrez] PHST- 2025/12/30 00:00 [pmc-release] AID - healthcare14010081 [pii] AID - healthcare-14-00081 [pii] AID - 10.3390/healthcare14010081 [doi] PST - epublish SO - Healthcare (Basel). 2025 Dec 30;14(1):81. doi: 10.3390/healthcare14010081. PMID- 41516406 OWN - NLM STAT- MEDLINE DCOM- 20260110 LR - 20260115 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 27 IP - 1 DP - 2026 Jan 5 TI - Novel SIM1 Variants Expanding the Spectrum of SIM1-Related Obesity. LID - 10.3390/ijms27010533 [doi] LID - 533 AB - Monogenic forms of severe early-onset obesity often involve genetic disruptions in the hypothalamic leptin-melanocortin pathway. Pathogenic variants in the SIM1 gene, a key transcription factor required for the development of the paraventricular nucleus, are a known cause of Prader-Willi-like syndrome, characterized by hyperphagia, severe obesity, and developmental delay. We performed targeted next-generation sequencing of 52 obesity-associated genes on a cohort of pediatric patients with severe early-onset obesity. Identified variants were analyzed for population frequency and predicted pathogenicity using in silico tools. The structural impact of the novel missense variants was assessed using protein domain modeling with AlphaFold3. We identified five rare SIM1 variants in eleven patients. Four were heterozygous nonsynonymous variants: one frameshift in the bHLH domain (p.Ser18Ter), one frameshift in the Per-ARNT-Sim domain (p.His143Ter), and two missense variants, p.Pro30Ala and p.Ser663Leu. Structural modeling suggested that the missense variants are likely to disrupt critical protein-protein interactions. The fifth variant was a synonymous change, c.1173G>A, p.(Ser391Ser), which was detected in five unrelated patients. Bioinformatic analysis predicted that this variant could alter splicing. Structural modeling suggested that the missense variants interfere with SIM1 function. This study expands the mutational spectrum of SIM1-linked monogenic obesity, reporting novel likely pathogenic frameshift variants, a missense variant, and a recurrent synonymous variant with a potential splice-site effect. The majority of the variants are predicted to affect the SIM1 protein. Our findings strengthen the critical role of the SIM1 gene in hypothalamic development and energy homeostasis. The results underscore the importance of including the SIM1 gene in genetic testing panels for children with severe obesity and hyperphagia, enabling precise diagnosis and potential future personalized management. Functional in vitro or in vivo validation of these variants is required to confirm their pathogenicity. FAU - Mohammed, Idris AU - Mohammed I AUID- ORCID: 0000-0002-8983-0929 AD - College of Health & Life Sciences, Hamad Bin Khalifa University, Doha P.O. Box 34110, Qatar. AD - Division of Endocrinology, Department of Pediatric Medicine, Sidra Medicine, Doha P.O. Box 26999, Qatar. FAU - Ahmed, Wesam S AU - Ahmed WS AUID- ORCID: 0000-0002-3441-2631 AD - College of Health & Life Sciences, Hamad Bin Khalifa University, Doha P.O. Box 34110, Qatar. FAU - Al-Barazenji, Tara AU - Al-Barazenji T AD - Division of Endocrinology, Department of Pediatric Medicine, Sidra Medicine, Doha P.O. Box 26999, Qatar. FAU - Dauleh, Hajar AU - Dauleh H AD - Division of Endocrinology, Department of Pediatric Medicine, Sidra Medicine, Doha P.O. Box 26999, Qatar. FAU - Love, Donald R AU - Love DR AUID- ORCID: 0000-0003-4669-8769 AD - Division of Genetic Pathology, Department of Pathology, Sidra Medicine, Doha P.O. Box 26999, Qatar. FAU - Hussain, Khalid AU - Hussain K AUID- ORCID: 0000-0002-5480-7112 AD - Division of Endocrinology, Department of Pediatric Medicine, Sidra Medicine, Doha P.O. Box 26999, Qatar. LA - eng GR - QNRF-NPRP 10-6100017-AXX)/qnrf/ PT - Journal Article DEP - 20260105 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - 0 (Basic Helix-Loop-Helix Proteins) RN - 0 (Repressor Proteins) RN - 0 (SIM1 protein, human) SB - IM MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - *Basic Helix-Loop-Helix Proteins/genetics/chemistry/metabolism MH - Frameshift Mutation MH - Genetic Predisposition to Disease MH - Models, Molecular MH - Mutation, Missense MH - *Obesity/genetics MH - *Pediatric Obesity/genetics MH - *Repressor Proteins/genetics/chemistry/metabolism PMC - PMC12786438 OTO - NOTNLM OT - Prader-Willi-like syndrome OT - SIM1 OT - early-onset obesity OT - hyperphagia OT - leptin-melanocortin OT - monogenic obesity COIS- The authors declare no conflicts of interest. EDAT- 2026/01/10 06:32 MHDA- 2026/01/10 06:33 PMCR- 2026/01/05 CRDT- 2026/01/10 01:11 PHST- 2025/11/05 00:00 [received] PHST- 2025/12/25 00:00 [revised] PHST- 2025/12/30 00:00 [accepted] PHST- 2026/01/10 06:33 [medline] PHST- 2026/01/10 06:32 [pubmed] PHST- 2026/01/10 01:11 [entrez] PHST- 2026/01/05 00:00 [pmc-release] AID - ijms27010533 [pii] AID - ijms-27-00533 [pii] AID - 10.3390/ijms27010533 [doi] PST - epublish SO - Int J Mol Sci. 2026 Jan 5;27(1):533. doi: 10.3390/ijms27010533. PMID- 41515295 OWN - NLM STAT- MEDLINE DCOM- 20260110 LR - 20260920 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 1 DP - 2026 Jan 5 TI - Physical Activity Determinants Under the Double Burden of Malnutrition: Contrasting Pathways for Underweight and Overweight Chinese Adolescents. LID - 10.3390/nu18010179 [doi] LID - 179 AB - BACKGROUND: Chinese adolescents face a dual burden of malnutrition, yet the weight-status-specific mechanisms underlying physical activity (PA) participation remain underexplored. METHODS: We conducted a cross-sectional study among 1573 adolescents (aged 9-15 years) in Shangrao City, China. Validated scales measured social-ecological factors (family/peer support, physical environment), psychological factors (stage of change, self-efficacy, decisional balance), and PA participation. Data preprocessing utilized full information maximum likelihood to handle missing values. Confirmatory factor analysis was performed to validate the measurement model, followed by multi-group structural equation modeling to analyze pathway configurations across underweight (n = 187), normal-weight (n = 1070), and overweight/obese (n = 316) groups. Mediation effects were tested using bootstrapping with 5000 resamples. RESULTS: Clear weight-specific patterns emerged. Normal-weight adolescents presented a fully functional comprehensive model where PA was predicted by the stage of change (beta = 0.211, p < 0.001), friend support (beta = 0.120, p < 0.001), self-efficacy (beta = 0.092, p < 0.05), and perceived benefits (beta = 0.095, p < 0.01). Underweight adolescents primarily relied on internal readiness driven by stage of change (beta = 0.270, p < 0.001) and self-efficacy (beta = 0.164, p < 0.05), with family support only indirectly influencing participation via psychological mediators. In contrast, overweight/obese adolescents showed a "socially dependent" pattern: friend support directly predicted PA levels (beta = 0.136, p < 0.05), significantly enhanced self-efficacy (beta = 0.370, p < 0.01), and effectively lowered perceived barriers (beta = -0.165, p < 0.05). Additionally, the physical environment strongly impacted perceived benefits (beta = 0.471, p < 0.01) but did not translate into action. CONCLUSIONS: These findings underscore the significant differences in PA determinants across the spectrum of malnutrition, necessitating targeted public health interventions to support the Healthy China 2030 initiative. FAU - Yao, Liying AU - Yao L AD - School of Physical Education and Sport Science, Guangzhou University, Guangzhou 510006, China. AD - Exercise and Sports Science Programme, School of Health Sciences, University Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia. FAU - Jia, Shuaishuai AU - Jia S AUID- ORCID: 0000-0003-1809-9566 AD - Guangzhou Institute of International Finance, Guangzhou University, Guangzhou 510006, China. FAU - Lv, Xiaochang AU - Lv X AD - School of Physical Education and Sport Science, Guangzhou University, Guangzhou 510006, China. FAU - Dai, Yongguan AU - Dai Y AD - School of Physical Education and Sport Science, Guangzhou University, Guangzhou 510006, China. FAU - Kueh, Yee Cheng AU - Kueh YC AUID- ORCID: 0000-0003-2125-7297 AD - Biostatistics and Research Methodology Unit, School of Medical Sciences, University Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia. FAU - Xu, Jinfu AU - Xu J AD - Journal Center, Guangzhou Sport University, Guangzhou 510500, China. FAU - Cong, Jianqiu AU - Cong J AD - College of Physical Education, Kaili University, Kaili 556011, China. FAU - Kuan, Garry AU - Kuan G AD - Exercise and Sports Science Programme, School of Health Sciences, University Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia. LA - eng GR - 24ATY001/National Office for Philosophy and Social Sciences/ PT - Journal Article DEP - 20260105 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - Chinese people SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - *Exercise/psychology MH - *Thinness/psychology/epidemiology MH - Cross-Sectional Studies MH - China/epidemiology MH - Child MH - *Overweight/psychology/epidemiology MH - Self Efficacy MH - *Malnutrition/psychology/epidemiology MH - Social Support MH - East Asian People PMC - PMC12788145 OTO - NOTNLM OT - Social-Ecological Model OT - Transtheoretical Model OT - body mass index OT - multi-group structural equation modeling OT - precision public health COIS- The authors declare no conflicts of interest. EDAT- 2026/01/10 06:32 MHDA- 2026/01/10 06:33 PMCR- 2026/01/05 CRDT- 2026/01/10 01:05 PHST- 2025/12/07 00:00 [received] PHST- 2025/12/29 00:00 [revised] PHST- 2026/01/03 00:00 [accepted] PHST- 2026/01/10 06:33 [medline] PHST- 2026/01/10 06:32 [pubmed] PHST- 2026/01/10 01:05 [entrez] PHST- 2026/01/05 00:00 [pmc-release] AID - nu18010179 [pii] AID - nutrients-18-00179 [pii] AID - 10.3390/nu18010179 [doi] PST - epublish SO - Nutrients. 2026 Jan 5;18(1):179. doi: 10.3390/nu18010179. PMID- 41515278 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 1 DP - 2026 Jan 3 TI - Cultural Adaptation and Reliability Testing of the Coeliac Disease Food Attitudes and Behaviours Scale in Brazil. LID - 10.3390/nu18010162 [doi] LID - 162 AB - Background: Coeliac disease (CD) is an autoimmune chronic condition that requires a strict diet without gluten as a single effective treatment. However, adherence to a life-long gluten-free diet (GFD) may promote psychological suffering and disordered eating. The Coeliac Disease Food Attitudes and Behaviours Scale (CD-FAB) is the only instrument specifically designed to evaluate these aspects in individuals with CD. Objective: This study aimed to translate the CD-FAB and test its reliability in the Brazilian population. Methods: The research was conducted in three stages: (i) translation and cultural adaptation of CD-FAB into Brazilian Portuguese; (ii) pretesting with Brazilian individuals diagnosed with CD to assess item understanding; and (iii) psychometric evaluation through reproducibility (test-retest reliability) via intraclass correlation coefficient (ICC) and internal consistency via Cronbach's alpha. Results: The CD-FAB was successfully adapted to the Brazilian CD population (Child CD-FAB-BR) and demonstrated strong internal consistency (alpha = 0.807) and an intraclass correlation coefficient (ICC = 0.928). Conclusions: The Brazilian version of CD-FAB proved to be reliable for assessing food attitudes and behaviours in people with CD, potentially allowing for the identification of factors to guide research and clinical practice by driving behaviour-based strategies to improve nutritional education and strategic policies for coeliac patients. Studies with larger and more diverse samples are recommended to provide external validation of the instrument. FAU - Ribeiro, Camila Dos Santos AU - Ribeiro CDS AUID- ORCID: 0000-0002-2770-1603 AD - Department of Nutrition, University Center of the Institute of Higher Education of Brasilia, Brasilia 70200-730, Brazil. FAU - Nakano, Eduardo Yoshio AU - Nakano EY AUID- ORCID: 0000-0002-9071-8512 AD - Department of Statistics, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Zandonadi, Renata Puppin AU - Zandonadi RP AUID- ORCID: 0000-0003-0370-3089 AD - Department of Nutrition, University of Brasilia, Brasilia 70910-900, Brazil. LA - eng GR - Edital 03/2025-n masculine 00193-00001084/2025-17/Fundacao De Apoio a Pesquisa do Distrito Federal-FAP/DF/ PT - Journal Article DEP - 20260103 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Celiac Disease/psychology/diet therapy MH - Brazil MH - Female MH - Reproducibility of Results MH - *Diet, Gluten-Free/psychology MH - Male MH - Psychometrics MH - Adult MH - *Feeding Behavior/psychology MH - Surveys and Questionnaires MH - Adolescent MH - Middle Aged MH - Young Adult MH - Child MH - *Health Knowledge, Attitudes, Practice PMC - PMC12787950 OTO - NOTNLM OT - CD-FAB OT - coeliac disease OT - eating behaviours OT - gluten-free diet OT - questionnaire COIS- The authors declare that they have no conflicts of interest. EDAT- 2026/01/10 06:32 MHDA- 2026/01/10 06:33 PMCR- 2026/01/03 CRDT- 2026/01/10 01:05 PHST- 2025/10/30 00:00 [received] PHST- 2025/12/17 00:00 [revised] PHST- 2025/12/25 00:00 [accepted] PHST- 2026/01/10 06:33 [medline] PHST- 2026/01/10 06:32 [pubmed] PHST- 2026/01/10 01:05 [entrez] PHST- 2026/01/03 00:00 [pmc-release] AID - nu18010162 [pii] AID - nutrients-18-00162 [pii] AID - 10.3390/nu18010162 [doi] PST - epublish SO - Nutrients. 2026 Jan 3;18(1):162. doi: 10.3390/nu18010162. PMID- 41515266 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260625 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 1 DP - 2026 Jan 1 TI - Parallel Improvement of Both Mental and Cardiometabolic Health in Children and Adolescents with Overweight and Obesity, Following the Implementation of a Multidisciplinary Lifestyle Intervention Program. LID - 10.3390/nu18010150 [doi] LID - 150 AB - Background: Overweight and obesity in childhood and adolescence represent one of the most significant public health challenges of our century. Affected children and adolescents often face psychosocial maladaptation, including low self-esteem, depressive and anxiety symptoms, and behavioral problems, many of which may persist till later in life. The aim of our study was to evaluate the impact of a multidisciplinary, personalized lifestyle intervention program on psychosocial and behavioral symptoms, assessed through standardized psychometric questionnaires, and to investigate their relation with cardiometabolic parameters in children and adolescents with overweight and obesity. Methods: In this prospective cohort study, 537 children and adolescents (6-18 years; females: 52.9%; pubertal: 43.6%) with obesity (n = 44.3%), overweight (n = 33.7%), or normal BMI (n = 22%) participated in a personalized lifestyle intervention program for one year. Clinical and laboratory evaluations, including anthropometric, cardiometabolic, and endocrinologic parameters, as well as psychosocial functioning assessed by the Child Behavior Checklist (CBCL) and Youth Self-Report (YSR), were performed at the beginning and the end of the study. Linear regression analyses identified predictors of psychometric change. Results: At initial evaluation, children and adolescents with obesity displayed a less favorable cardiometabolic profile and greater emotional/conduct difficulties compared to their overweight and normal-BMI counterparts. Following the intervention, significant improvements were observed in BMI, anthropometric and cardiometabolic parameters, as well as reductions in internalizing, externalizing, and total problem scores across multiple CBCL and YSR domains (p < 0.05). The improvements in psychosocial functioning were partly independent of BMI reduction. Linear regression analyses identified cardiometabolic and endocrine markers as significant predictors of psychometric change (p < 0.05), highlighting interactions between metabolic recovery, pubertal hormones, and stress physiology. Conclusions: A personalized, multidisciplinary lifestyle intervention program implemented for 1 year led to parallel improvements in psychosocial and cardiometabolic health in children and adolescents with overweight and obesity. Identification of specific metabolic and endocrine predictors provides novel insights into potential biological mechanisms associated with adiposity, emotional well-being, and neurodevelopment. FAU - Vourdoumpa, Aikaterini AU - Vourdoumpa A AUID- ORCID: 0000-0002-6277-9959 AD - Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece. FAU - Paltoglou, George AU - Paltoglou G AUID- ORCID: 0000-0003-4300-7061 AD - Division of Endocrinology, Diabetes and Metabolism, Second Department of Pediatrics, National and Kapodistrian University of Athens, "P. & A. Kyriakou" Children's Hospital, 11527 Athens, Greece. FAU - Manou, Maria AU - Manou M AUID- ORCID: 0000-0002-9584-0373 AD - Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece. FAU - Koutaki, Diamanto AU - Koutaki D AD - Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece. FAU - Kassari, Penio AU - Kassari P AUID- ORCID: 0000-0003-2464-1825 AD - Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece. AD - Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece. FAU - Papadopoulou, Marina AU - Papadopoulou M AD - Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece. FAU - Kolaitis, Gerasimos AU - Kolaitis G AD - Department of Child Psychiatry, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece. FAU - Charmandari, Evangelia AU - Charmandari E AUID- ORCID: 0000-0002-0851-6998 AD - Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece. AD - Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece. LA - eng GR - with the promotional phrase "LoseWeight-Gain Life" (MIS 370545)/(i) National Strategic Reference Framework (NSRF) 2007-2013 under the operational program "Human Resources Development" (EP.AN.A.D) 2007-2013 and was co-funded by the European Social Fund (ESF) and national funding/ GR - (project code: T1EDK-01386, MIS: 5030543, acronym: PEDOBESITY)/(ii) the European Regional Development Fund of the European Union and Greek national funds through the operational program "Competitiveness, Entrepreneurship, and Innovation" (EPA-nEK 2014-2020), under the call RESEARCH-CREATE-INNOVATE/ PT - Journal Article DEP - 20260101 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - Female MH - Child MH - Male MH - Prospective Studies MH - *Mental Health MH - *Pediatric Obesity/psychology/therapy MH - *Life Style MH - Body Mass Index MH - *Overweight/psychology/therapy MH - Psychometrics MH - Risk Reduction Behavior PMC - PMC12787964 OTO - NOTNLM OT - CBCL OT - YSR OT - cardiometabolic health OT - lifestyle intervention OT - mental health OT - obesity OT - overweight OT - youth COIS- The authors declare no conflicts of interest. The funding sources played no part in the study's design, data collection, analysis, or interpretation, the drafting of the manuscript, or the decision to publish the findings. EDAT- 2026/01/10 06:31 MHDA- 2026/01/10 06:32 PMCR- 2026/01/01 CRDT- 2026/01/10 01:05 PHST- 2025/11/20 00:00 [received] PHST- 2025/12/22 00:00 [revised] PHST- 2025/12/25 00:00 [accepted] PHST- 2026/01/10 06:32 [medline] PHST- 2026/01/10 06:31 [pubmed] PHST- 2026/01/10 01:05 [entrez] PHST- 2026/01/01 00:00 [pmc-release] AID - nu18010150 [pii] AID - nutrients-18-00150 [pii] AID - 10.3390/nu18010150 [doi] PST - epublish SO - Nutrients. 2026 Jan 1;18(1):150. doi: 10.3390/nu18010150. PMID- 41515169 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260920 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 1 DP - 2025 Dec 23 TI - Parental Culinary Skills and Children's Eating Behavior in Brazil: A Cross-Sectional Study. LID - 10.3390/nu18010051 [doi] LID - 51 AB - BACKGROUND: Childhood obesity is a persistent global health challenge, often rooted in early-life dietary patterns shaped within the home environment. OBJECTIVE: To investigate the association between parents' culinary skills, children's eating behavior, and the degree of child involvement in family culinary practices. METHODS: A cross-sectional, analytical study. In the public and private schools in southern Brazil. A total of 205 families with children aged 3 to 13 years participated. Parents or caregivers answered a structured questionnaire on culinary skills and sociodemographic variables. Children's eating behavior was assessed through the validated Brazilian version of the Children's Eating Behaviour Questionnaire (CEBQ). Student's T test was used to compare means, and Pearson's chi-square or Fisher's exact test to compare proportions. Multivariate linear regression was applied to control for potential confounders. Analyses were conducted using SPSS version 27.0 and R software. RESULTS: Most parents (90.7%) reported cooking regularly, and 65.9% involved children in cooking activities. The predominant culinary profile (40%) was classified as "convenience cooking," marked by frequent use of processed ingredients. Healthier parental cooking practices were positively associated with adaptive eating behaviors in children, reflected by lower food fussiness, satiety responsiveness, food responsiveness and food refusal scores and higher enjoyment of food scores domains of the CEBQ. CONCLUSIONS: Despite the high prevalence of routine cooking, convenience-oriented practices remain dominant, reflecting broader sociocultural patterns. Engagement in healthier cooking practices was positively associated with more favorable eating behaviors in children. These findings underscore the importance of promoting culinary education and parental involvement in cooking as strategies to support healthy childhood eating behaviors. FAU - Dos Santos, Thais Souza AU - Dos Santos TS AD - Graduate Program in Pediatrics and Child Health, Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Ipiranga Avenue, 6681, Porto Alegre 90610-970, RS, Brazil. FAU - Ayala, Camila Ospina AU - Ayala CO AUID- ORCID: 0000-0003-1414-7495 AD - Graduate Program in Pediatrics and Child Health, Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Ipiranga Avenue, 6681, Porto Alegre 90610-970, RS, Brazil. FAU - Peuckert, Marina Zanette AU - Peuckert MZ AUID- ORCID: 0000-0002-7159-9482 AD - Graduate Program in Pediatrics and Child Health, Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Ipiranga Avenue, 6681, Porto Alegre 90610-970, RS, Brazil. FAU - Martins, Carla Adriano AU - Martins CA AUID- ORCID: 0000-0002-6902-0232 AD - Collective Feeding Program, Institute of Food and Nutrition, Federal University Rio de Janeiro (UFRJ)-UFRJ-Macae Multidisciplinary Center (CM UFRJ-Macae), Carlos Chagas Filho Avenue, 373, Macae 21941-902, RJ, Brazil. FAU - Feoli, Ana Maria Pandolfo AU - Feoli AMP AUID- ORCID: 0000-0001-7685-8431 AD - Graduate Program in Pediatrics and Child Health, Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Ipiranga Avenue, 6681, Porto Alegre 90610-970, RS, Brazil. FAU - Bulla, Micaella Bassanesi AU - Bulla MB AD - Graduate Program in Pediatrics and Child Health, Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Ipiranga Avenue, 6681, Porto Alegre 90610-970, RS, Brazil. FAU - Taffarel, Joao Pedro Soares AU - Taffarel JPS AD - Graduate Program in Pediatrics and Child Health, Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Ipiranga Avenue, 6681, Porto Alegre 90610-970, RS, Brazil. FAU - Drumond Costa, Caroline Abud AU - Drumond Costa CA AD - Graduate Program in Pediatrics and Child Health, Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Ipiranga Avenue, 6681, Porto Alegre 90610-970, RS, Brazil. LA - eng PT - Journal Article DEP - 20251223 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Brazil MH - Female MH - Male MH - *Feeding Behavior/psychology MH - Child MH - *Cooking MH - Child, Preschool MH - *Parents/psychology MH - *Child Behavior MH - Adolescent MH - Surveys and Questionnaires MH - *Parenting MH - Diet, Healthy MH - Food Fussiness PMC - PMC12787823 OTO - NOTNLM OT - children's eating behaviour questionnaire OT - cooking OT - culinary skills OT - food preparation behaviors OT - parenting COIS- The authors report no conflicts of interest regarding the content of this study. EDAT- 2026/01/10 06:31 MHDA- 2026/01/10 06:32 PMCR- 2025/12/23 CRDT- 2026/01/10 01:05 PHST- 2025/09/15 00:00 [received] PHST- 2025/10/16 00:00 [revised] PHST- 2025/10/24 00:00 [accepted] PHST- 2026/01/10 06:32 [medline] PHST- 2026/01/10 06:31 [pubmed] PHST- 2026/01/10 01:05 [entrez] PHST- 2025/12/23 00:00 [pmc-release] AID - nu18010051 [pii] AID - nutrients-18-00051 [pii] AID - 10.3390/nu18010051 [doi] PST - epublish SO - Nutrients. 2025 Dec 23;18(1):51. doi: 10.3390/nu18010051. PMID- 41515167 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260625 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 1 DP - 2025 Dec 23 TI - Cross-Cultural Adaptation and Psychometric Properties of the Reward-Based Eating Drive Scale (RED-13) and Its Brief Version (RED-5X) in Three European Countries. LID - 10.3390/nu18010049 [doi] LID - 49 AB - Background and aims: Reward-based eating reflects hedonic drivers of intake, including loss of control, diminished satiety, and preoccupation with food. We translated, adapted and studied the psychometric properties of the 13- and 5-item Reward-Based Eating Drive Scale (RED), for Portugal, Poland and Italy. Methods: A cross-cultural study was conducted with higher education students and general population samples (n = 1999). After translation and cultural adaptation, the RED was administered with food craving items, and collection of sociodemographic and anthropometric data. Factorial structure and measurement invariance were tested using confirmatory factor analysis (CFA), internal consistency with Cronbach's alpha, and convergent validity via correlations with BMI and cravings. Results: CFA supported the expected structures of the RED-13 (three factors) and RED-X5 (unifactorial), with configural and metric invariance across countries and groups. Only partial scalar invariance was achieved for both versions. The RED-13 showed good to excellent internal consistency for total scores (0.868 /=10 years, the sample predominantly consisted of adults, and only about one-quarter fell within the WHO-defined youth category (10-24 years). A structured, validated questionnaire was administered to 420 participants. Obesity and AN were assessed using self-report rather than clinical examination, which may introduce misclassification bias. Fasting glucose and HbA1c values were recorded when available; however, laboratory data were only accessible for a small subset of participants and were therefore interpreted cautiously. RESULTS: The mean age of participants was 35.1+/-14.3 years. The overall prevalence of AN was 17.3%, and self-reported obesity was 24.0%. Because laboratory values were available for only a minority, related findings are considered exploratory rather than representative of the total sample. AN was significantly associated with obesity (p=0.005). CONCLUSION: AN was relatively common in this mixed-age population. Given that only a small proportion of participants met the youth definition, results should not be interpreted as representing "young people" exclusively. FAU - Alharbi, M AU - Alharbi M AD - 1Department of Medicine, College of Medicine, Qassim University, Buraydah, Al-Qassim, Saudi Arabia. FAU - Albarrak, R AU - Albarrak R AD - 2Department of General Surgery, King Fahad Specialist Hospital, Buraydah, Qassim, Saudi Arabia. FAU - Alnassar, A AU - Alnassar A AD - 3Qassim University, College of Medicine Buraidah, Saudi Arabia. FAU - Alsweed, K AU - Alsweed K AD - 3Qassim University, College of Medicine Buraidah, Saudi Arabia. FAU - Almutairi, A AU - Almutairi A AD - 4Department of Internal Medicine, Qassim Health Cluster, Qassim, Saudi Arabia. FAU - Albarrak, R AU - Albarrak R AD - 3Qassim University, College of Medicine Buraidah, Saudi Arabia. FAU - Alqurishi, J AU - Alqurishi J AD - 3Qassim University, College of Medicine Buraidah, Saudi Arabia. LA - eng PT - Journal Article PT - Multicenter Study PL - Georgia (Republic) TA - Georgian Med News JT - Georgian medical news JID - 101218222 RN - 0 (Blood Glucose) RN - 0 (Glycated Hemoglobin) SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - *Acanthosis Nigricans/epidemiology/complications/blood MH - Female MH - Male MH - Adult MH - Risk Factors MH - *Obesity/epidemiology/complications MH - Cross-Sectional Studies MH - Middle Aged MH - *Diabetes Mellitus, Type 2/epidemiology/complications/blood MH - Adolescent MH - Prevalence MH - Child MH - Young Adult MH - Blood Glucose MH - Glycated Hemoglobin/metabolism EDAT- 2026/01/09 13:33 MHDA- 2026/01/09 13:34 CRDT- 2026/01/09 09:03 PHST- 2026/01/09 13:34 [medline] PHST- 2026/01/09 13:33 [pubmed] PHST- 2026/01/09 09:03 [entrez] PST - ppublish SO - Georgian Med News. 2025 Nov;(368):98-111. PMID- 41508045 OWN - NLM STAT- MEDLINE DCOM- 20260413 LR - 20260813 IS - 1464-5491 (Electronic) IS - 0742-3071 (Print) IS - 0742-3071 (Linking) VI - 43 IP - 5 DP - 2026 May TI - Can the Diabetes Eating Problem Survey-Revised (DEPS-R) reliably identify eating disorder diagnosis in women with type 1 diabetes? PG - e70207 LID - 10.1111/dme.70207 [doi] LID - e70207 AB - AIMS: The objective of this study was to evaluate the Diabetes Eating Problems Survey-Revised (DEPS-R) against the Eating Disorder Diagnostic Interview (EDDI). Specific aims were to (1) assess the ability of the DEPS-R to identify Diagnostic and Statistical Manual-5 (DSM-5) eating disorders, including sensitivity and specificity of the current DEPS-R cutoff >/=20 and (2) report the correlation of each item to the presence of any eating disorder. METHODS: Baseline data from 293 women (14-35 years) with type 1 diabetes (T1D) and body image concerns enrolled in a multinational randomized controlled trial were examined. Receiver operating characteristic (ROC) analysis, univariate logistic regression and two-sample t-test were performed. RESULTS: The ROC analysis demonstrated good accuracy of the DEPS-R with an area under the curve (AUC) of 0.82 (95% CI 0.79-0.94). The cutoff of >/=20 yielded a sensitivity of 87.5% (95% CI 83.6%-91.3%) and a specificity of 60.4% (95% CI 54.8%-66.0%). Univariate logistic regression identified 12 items as significantly correlated with the presence of any eating disorder. The highest odds ratios (OR) were observed for items 9 (OR = 3.64), 8 (OR = 2.85), 13 (OR = 2.36), 14 (OR = 2.23), 15 (OR = 1.99) and 5 (OR = 1.99). CONCLUSIONS: This is the first study to investigate the ability of the DEPS-R to identify DSM-5 eating disorder diagnosis established via a diagnostic interview using a ROC-analysis. DEPS-R cutoff >/=20 correctly identified most cases with eating disorders but showed moderate specificity, considered acceptable as an initial screening tool for disordered eating. In clinical care, specific DEPS-R items may be emphasized to explore the presence of disordered eating behaviours and eating disorders. CI - (c) 2026 The Author(s). Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK. FAU - Haugvik, Severina AU - Haugvik S AUID- ORCID: 0009-0009-2909-2504 AD - Division of Mental Health and Addiction, Regional Department for Eating Disorders, Oslo University Hospital, Oslo, Norway. AD - Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. AD - Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway. FAU - Hennekes, Mareille H C L AU - Hennekes MHCL AD - Medical Psychology, Amsterdam UMC, Location Vrije Universiteit Amsterdam, Amsterdam, Netherlands. AD - Mental Health, Amsterdam Public Health, Amsterdam, Netherlands. FAU - de Wit, Maartje AU - de Wit M AUID- ORCID: 0000-0001-6029-5101 AD - Medical Psychology, Amsterdam UMC, Location Vrije Universiteit Amsterdam, Amsterdam, Netherlands. AD - Mental Health, Amsterdam Public Health, Amsterdam, Netherlands. FAU - Toschi, Elena AU - Toschi E AUID- ORCID: 0000-0003-4077-1160 AD - Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA. FAU - Desjardins, Christopher D AU - Desjardins CD AD - Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA. FAU - Skrivarhaug, Torild AU - Skrivarhaug T AD - Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. AD - Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway. AD - Oslo Diabetes Research Center, Oslo, Norway. FAU - Dahl-Jorgensen, Knut AU - Dahl-Jorgensen K AD - Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. AD - Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway. AD - Oslo Diabetes Research Center, Oslo, Norway. FAU - Stice, Eric AU - Stice E AD - Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA. FAU - Wisting, Line AU - Wisting L AUID- ORCID: 0000-0002-5424-7290 AD - Division of Mental Health and Addiction, Regional Department for Eating Disorders, Oslo University Hospital, Oslo, Norway. AD - Oslo Diabetes Research Center, Oslo, Norway. AD - Institute of Psychology, Oslo New University College, Oslo, Norway. LA - eng PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial DEP - 20260108 PL - England TA - Diabet Med JT - Diabetic medicine : a journal of the British Diabetic Association JID - 8500858 SB - IM MH - Humans MH - Female MH - *Diabetes Mellitus, Type 1/psychology/complications/epidemiology MH - *Feeding and Eating Disorders/diagnosis/complications/epidemiology/psychology MH - Adult MH - Adolescent MH - Young Adult MH - Sensitivity and Specificity MH - ROC Curve MH - Surveys and Questionnaires MH - Body Image/psychology MH - Diagnostic and Statistical Manual of Mental Disorders MH - Reproducibility of Results PMC - PMC13074148 OTO - NOTNLM OT - DEPS-R OT - assessment OT - eating pathology OT - type 1 diabetes COIS- The authors have no conflicts of interest to disclose related to this research project. EDAT- 2026/01/09 00:26 MHDA- 2026/04/13 12:38 PMCR- 2026/04/13 CRDT- 2026/01/08 23:55 PHST- 2025/11/26 00:00 [revised] PHST- 2025/09/09 00:00 [received] PHST- 2025/12/15 00:00 [accepted] PHST- 2026/04/13 12:38 [medline] PHST- 2026/01/09 00:26 [pubmed] PHST- 2026/01/08 23:55 [entrez] PHST- 2026/04/13 00:00 [pmc-release] AID - DME70207 [pii] AID - 10.1111/dme.70207 [doi] PST - ppublish SO - Diabet Med. 2026 May;43(5):e70207. doi: 10.1111/dme.70207. Epub 2026 Jan 8. PMID- 41506750 OWN - NLM STAT- MEDLINE DCOM- 20260108 LR - 20260912 IS - 2059-7908 (Print) IS - 2059-7908 (Electronic) IS - 2059-7908 (Linking) VI - 11 IP - 1 DP - 2026 Jan 8 TI - Impact of an integrated parenting and nutrition intervention on growth and development in stunted children at 24 months: evidence from the Stepping Stones programme in rural India. LID - 10.1136/bmjgh-2024-017395 [doi] LID - e017395 AB - OBJECTIVES: This paper examines the differential impact of responsive parenting and nutrition interventions on early child development in stunted versus never-stunted children at 24 months of age in rural India. METHODS: We conducted a secondary analysis of data from Stepping Stones-a cluster randomised controlled trial involving 21 subcentres/clusters allocated to intervention or control group. The intervention comprised home visits, group sessions and community workshops, focusing on responsive parenting and nutrition. Developmental outcomes, cognitive, motor, language and socio-emotional, were assessed at 24 months using validated tools. A mixed-effects regression model with an interaction term was used to estimate effect sizes for stunted and never-stunted children. RESULTS: Among 588 children analysed, 35.9% were stunted at 24 months, and 35 (5.95%) of them exhibited 'early-onset persistent stunting'. The intervention improved cognitive (beta=0.22), motor (beta=0.23), language (beta=0.17) and socio-emotional development (beta=0.23) in never-stunted children compared with those who have not received intervention. For stunted children who have not received the intervention, a development score was lower for all development domains compared with never-stunted children, but not statistically significant (p>0.05). Although the effects differed between stunted and never-stunted children, the interaction effects between intervention and stunting were not statistically significant across all domains (p>0.05), indicating that the intervention's benefits did not significantly differ by stunting status. CONCLUSION: Integrated parenting and nutrition interventions improved developmental outcomes across all domains, regardless of the child's stunting status. These findings support universal application of such programmes, highlighting the need to integrate them into existing child development and nutrition programmes. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Gaidhane, Abhay AU - Gaidhane A AUID- ORCID: 0000-0002-4814-2695 AD - Department of Community Medicine, Jawaharlal Nehru Medical College, Wardha; Global Health Academy of Nuvance Health, Danbury, CT, USA; Global Consortium Public Health Research, UK; Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India. FAU - Telrandhe, Shital AU - Telrandhe S AUID- ORCID: 0000-0002-3638-7724 AD - Centre of Early Childhood Development - Stepping Stones Project, Research and Development, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India shital.telrandhe88@gmail.com. FAU - Holding, Penny AU - Holding P AUID- ORCID: 0000-0002-4159-9115 AD - Centre of Early Childhood Development - Stepping Stones Project, Research and Develoment, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India. FAU - Khatib, Mahalaqua Nazli AU - Khatib MN AUID- ORCID: 0000-0001-5875-8277 AD - Department of Physiology, Jawaharlal Nehru Medical College, Wardha; Global Evidence Synthesis Initiative; Division of Evidence Synthesis, School of Epidemiology & Public Health, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India. FAU - Patil, Manoj AU - Patil M AUID- ORCID: 0000-0002-7126-5810 AD - Research and Development, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India. FAU - Gaidhane, Shilpa AU - Gaidhane S AUID- ORCID: 0000-0002-3012-7438 AD - Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India. FAU - Choudhari, Sonali G AU - Choudhari SG AUID- ORCID: 0000-0003-0642-5096 AD - Department of Community Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India. FAU - Umate, Roshan AU - Umate R AUID- ORCID: 0000-0002-0378-4723 AD - Centre of Early Childhood Development - Stepping Stones Project, Research and Development, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India. FAU - Saxena, Deepak AU - Saxena D AUID- ORCID: 0000-0003-0563-4259 AD - Indian Institute of Public Health, Gandhinagar, Gujarat, India. FAU - Syed, Zahiruddin Quazi AU - Syed ZQ AUID- ORCID: 0000-0002-1435-899X AD - Department of Community Medicine, Jawaharlal Nehru Medical College, Wardha; South Asia Infant Feeding Research Network (SAIFRN), Global Health Academy of Nuvance Health, Danbury, USA; ITE Research Foundation, Wardha; School of Epidemiology and Public Health; Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India. LA - eng SI - CTRI/CTRI/2017/05/008553 on 15 May 2017 PT - Journal Article PT - Randomized Controlled Trial DEP - 20260108 PL - England TA - BMJ Glob Health JT - BMJ global health JID - 101685275 SB - IM MH - Humans MH - India/epidemiology MH - Male MH - Child, Preschool MH - *Child Development MH - Female MH - *Growth Disorders/prevention & control/epidemiology MH - *Parenting MH - Rural Population MH - Infant MH - Nutritional Status PMC - PMC13059852 OTO - NOTNLM OT - Child health OT - Nutrition OT - Public Health OT - Stunting COIS- Competing interests: None declared. EDAT- 2026/01/09 00:26 MHDA- 2026/01/09 00:27 PMCR- 2026/01/08 CRDT- 2026/01/08 20:42 PHST- 2024/08/30 00:00 [received] PHST- 2025/12/21 00:00 [accepted] PHST- 2026/01/09 00:27 [medline] PHST- 2026/01/09 00:26 [pubmed] PHST- 2026/01/08 20:42 [entrez] PHST- 2026/01/08 00:00 [pmc-release] AID - bmjgh-2024-017395 [pii] AID - 10.1136/bmjgh-2024-017395 [doi] PST - epublish SO - BMJ Glob Health. 2026 Jan 8;11(1):e017395. doi: 10.1136/bmjgh-2024-017395. PMID- 41505748 OWN - NLM STAT- MEDLINE DCOM- 20260108 LR - 20260826 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Jan 8 TI - The Effect of Digital Therapy-Based Aerobic Exercise on Children With Neuroblastoma: Protocol for a Prospective Controlled Trial. PG - e72698 LID - 10.2196/72698 [doi] LID - e72698 AB - BACKGROUND: Neuroblastoma, one of the most common extracranial solid tumors in children, often results in significant functional impairments, including muscle atrophy, reduced motor function, and sensory disturbances. While aerobic exercise has been shown to support functional recovery in patients with cancer, digital therapy-based aerobic exercise interventions have not yet been explored in pediatric neuroblastoma. OBJECTIVE: This study aims to develop and evaluate a digital intervention therapy to provide a safe, feasible, and tolerable home-based physical activity initiation protocol for children with neuroblastoma after chemoradiotherapy, with the main objectives of (1) breaking sedentary behavior habits and increasing daily energy expenditure, (2) gradually improving physical function (flexibility, basic muscle strength and muscle endurance, and balance ability), (3) establishing the habit of regular exercise and improving exercise self-efficacy, and (4) laying the foundation for a possible transition to more standard, albeit low-risk, aerobic exercise. METHODS: A total of 68 participants will be recruited and allocated to 2 groups matched in age and gender, with consideration given to the preferences of participants and their guardians. The control group will receive standard in-hospital medical treatment and health education, whereas the experimental group will receive a 6-month digital therapy-based aerobic exercise intervention in addition to standard care. Outcomes will be assessed at baseline and 3 and 6 months, with data collected for analysis. The primary outcomes are the 6-minute walk distance and the timed scores (in seconds) for the timed up and go and stair climb tests. The secondary outcomes include body composition, grip strength, and quality of life measured using the Pediatric Quality of Life Inventory version 4.0. RESULTS: Recruitment will be conducted from December 2025 to September 2026. We expect that the intervention group will show significantly greater improvements in physical function, physical activity levels, and fatigue management than the control group, demonstrating the effectiveness of digital therapy for rehabilitation training after radiotherapy and chemotherapy for neuroblastoma in children. CONCLUSIONS: We expect that the results of this study will provide evidence for rehabilitation after chemoradiotherapy in pediatric patients with neuroblastoma to improve physical function, physical activity levels, and fatigue management. In the future, expanding to multiple centers to conduct targeted surveys of different types of childhood cancers will help validate the effectiveness of digital therapy. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/72698. CI - (c)Xuan Zhou, Shihao Huang, Lixia Wang, Haibin Guo, Sisi Chen, Tingrui Li, Qing Du. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 08.01.2026. FAU - Zhou, Xuan AU - Zhou X AUID- ORCID: 0000-0002-1568-6039 AD - Department of Rehabilitation Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China. FAU - Huang, Shihao AU - Huang S AUID- ORCID: 0000-0002-4044-3514 AD - Department of Pediatric Hematologic Oncology, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China. FAU - Wang, Lixia AU - Wang L AUID- ORCID: 0009-0009-9422-0146 AD - Department of Rehabilitation Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China. FAU - Guo, Haibin AU - Guo H AUID- ORCID: 0000-0003-0058-4555 AD - Department of Rehabilitation Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China. FAU - Chen, Sisi AU - Chen S AUID- ORCID: 0009-0008-0787-3417 AD - Department of Rehabilitation Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China. FAU - Li, Tingrui AU - Li T AUID- ORCID: 0009-0002-6363-0731 AD - Department of Rehabilitation Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China. FAU - Du, Qing AU - Du Q AUID- ORCID: 0000-0002-4349-5088 AD - Department of Rehabilitation Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20260108 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - Child MH - *Neuroblastoma/therapy/rehabilitation/physiopathology MH - *Exercise/physiology MH - *Exercise Therapy/methods MH - Prospective Studies MH - Male MH - Female MH - Quality of Life MH - Child, Preschool MH - Adolescent PMC - PMC12828307 OTO - NOTNLM OT - aerobic exercise OT - digital therapy OT - neuroblastoma OT - pediatrics OT - rehabilitation COIS- Conflicts of Interest: None declared. EDAT- 2026/01/08 19:23 MHDA- 2026/01/08 19:24 PMCR- 2026/01/08 CRDT- 2026/01/08 16:54 PHST- 2025/02/15 00:00 [received] PHST- 2025/11/10 00:00 [accepted] PHST- 2026/01/08 19:24 [medline] PHST- 2026/01/08 19:23 [pubmed] PHST- 2026/01/08 16:54 [entrez] PHST- 2026/01/08 00:00 [pmc-release] AID - v15i1e72698 [pii] AID - 10.2196/72698 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Jan 8;15:e72698. doi: 10.2196/72698. PMID- 41505421 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260625 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 1 DP - 2026 TI - Optimising gravimetric method interpretation using population-specific blood densities among Indonesian pregnant women: A cross-sectional study. PG - e0339391 LID - 10.1371/journal.pone.0339391 [doi] LID - e0339391 AB - BACKGROUND: The diagnosis of postpartum haemorrhage (PPH) depends heavily on accurate and timely blood loss assessment, yet no gold standard assessment method is available. Gravimetric methods are recommended for low-resource settings, but they require an accurate blood density value for interpretation. Currently, there are no data on the blood density of pregnant or labour women. OBJECTIVE: This study measured the blood density of Indonesian pregnant women to improve the reliability of the gravimetric results in estimating postpartum blood loss. METHODS: This cross-sectional study was conducted at a Private Midwifery Service Clinic in Bogor, Indonesia, involving 44 pregnant women who were at 37 weeks of gestation or later. During antenatal visits, 5 ml venous blood samples were collected, with women experiencing high-risk pregnancies being excluded. Descriptive statistics summarised the characteristics of the participants. Spearman's rank-order correlation was used to assess associations between study variables, and the Kruskal-Wallis test evaluated group differences. RESULTS: The mean blood density was 1.060 +/- 0.080 g/ml (range: 0.860-1.194 g/ml), with stable indoor and outdoor temperatures of 27 degrees C (SD = 1.13 degrees C and 1.22 degrees C, respectively). No significant correlations were found between blood density and maternal age, pre-pregnancy BMI, or gestational weight gain (p > 0.05). Kruskal-Wallis tests also revealed no significant differences across these variables (p > 0.05). CONCLUSION: Blood density among Indonesian pregnant women corresponds with established human reference values, supporting the use of population-specific blood density values to improve gravimetric blood loss estimation accuracy, thus facilitating early detection and prompt intervention of PPH. The observed variability suggests that factors other than demographics, maternal anthropometry, and the environment may affect blood density, necessitating further investigation in larger multisite studies. This study was reported in accordance with the STROBE checklist; the completed checklist is available as Supporting Information (S1 File). This study employed a cross-sectional design to measure blood densities of pregnant women at a single point in time. Participants were recruited during antenatal visits at Dyan's Private Midwifery-Service Clinic, Gunung Putri, Bogor, West Java, Indonesia. The health facility is a primary-level facility led by midwives and serves as the community's first point of contact for maternal and child health services. The health facility offers routine maternal health services, including antenatal care, childbirth assistance, postpartum follow-up, and family planning. As a primary-level facility, this health facility only provided care for women with low-risk pregnancies following the midwife's authority, while women with high-risk pregnancies or obstetrical/pathological conditions were referred to referral or obstetrician-led care facilities. The facility, situated in Gunung Putri, an industrial area adjacent to the capital city (Jakarta), serves a stable yet demographically diverse population drawn from various provinces and socioeconomic backgrounds, offering heterogeneous and broadly representative of Indonesia's diverse demographics. Although not fully representative of rural or coastal populations, the site offers a scientifically appropriate environment for studying blood density among pregnant Indonesian women. Prior to the commencement of the study, the participating facility provided permission for data collection. Data collection began on 8th January 2025 and ended on 21st April 2025. This study included pregnant women 37 weeks pregnant or older (based on the first day of the last menstrual cycle). To measure blood density, 5 ml venous blood samples were collected from all eligible participants. Pregnant women at high risk of pregnancy complications were not eligible to participate in the study. To ensure appropriate representation of the target population in this study, the sample size was determined using the Slovin formula by considering the total number of antenatal visits at Dyan's Private Midwifery Service Clinic between November 2023 and October 2024, which was 2,576. With an error tolerance of 0.15, a sample of 44 pregnant women was deemed sufficient to balance statistical precision with study feasibility. Given the exploratory, cross-sectional nature of the work, which focused on estimating blood density rather than group comparisons or hypothesis testing, this margin of error provided an acceptable level of precision. Accordingly, a sample size of 44 was adequate to support the optimisation of the gravimetric method for estimating postpartum blood loss. A consecutive sampling method was used to recruit participants. All pregnant women at the study site who met the predefined inclusion criteria were invited to participate in the study. Recruitment continued until the target sample size was achieved. As a preliminary cross-sectional study to estimate blood density and not population-level prevalence, consecutive sampling was considered suitable. All eligible participants were enrolled during the study period to minimise selection bias. CI - Copyright: (c) 2026 Mudarris et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Mudarris, Nelil AU - Mudarris N AD - Department of Midwifery, Universitas Bima Sakapenta, Bogor, Indonesia. FAU - Indrayani, Indrayani AU - Indrayani I AUID- ORCID: 0000-0002-4312-9061 AD - School of Human and Health Sciences, University of Huddersfield, Huddersfield, United Kingdom. AD - Department of Midwifery, Akademi Kebidanan Bina Husada Tangerang, Banten, Indonesia. FAU - Sudjarwo, Wisnu Arfian A AU - Sudjarwo WAA AD - Institute of Biophysics, Department of Natural Science and Sustainable Resources, BOKU University, Vienna, Austria. FAU - Anggraini, Dewi AU - Anggraini D AD - Department of Statistics, Faculty of Mathematics and Natural Sciences, Universitas Lambung Mangkurat, South Kalimantan, Indonesia. FAU - Oktaviany, Dyan AU - Oktaviany D AD - Department of Midwifery, Politeknik Bakti Asih Purwakarta, West Java, Indonesia. FAU - Singh, Devendra Raj AU - Singh DR AD - School of Human and Health Sciences, University of Huddersfield, Huddersfield, United Kingdom. FAU - Nugraheni, Galuh AU - Nugraheni G AD - Department of Midwifery, Universitas Bima Sakapenta, Bogor, Indonesia. FAU - Syafa'ah, Aminah AU - Syafa'ah A AD - Department of Midwifery, Universitas Bima Sakapenta, Bogor, Indonesia. LA - eng PT - Journal Article DEP - 20260108 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Cross-Sectional Studies MH - Indonesia MH - Adult MH - *Postpartum Hemorrhage/diagnosis/blood MH - Young Adult PMC - PMC12782393 COIS- The authors have declared that no competing interests exist. EDAT- 2026/01/08 19:23 MHDA- 2026/01/08 19:24 PMCR- 2026/01/08 CRDT- 2026/01/08 13:33 PHST- 2025/08/13 00:00 [received] PHST- 2025/12/05 00:00 [accepted] PHST- 2026/01/08 19:24 [medline] PHST- 2026/01/08 19:23 [pubmed] PHST- 2026/01/08 13:33 [entrez] PHST- 2026/01/08 00:00 [pmc-release] AID - PONE-D-25-43136 [pii] AID - 10.1371/journal.pone.0339391 [doi] PST - epublish SO - PLoS One. 2026 Jan 8;21(1):e0339391. doi: 10.1371/journal.pone.0339391. eCollection 2026. PMID- 41503664 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260625 IS - 1460-9592 (Electronic) IS - 1155-5645 (Linking) VI - 36 IP - 4 DP - 2026 Apr TI - Reliability of the Pediatric-Specific American Society of Anesthesiologists Physical Status (ASA-PS) Classification System. PG - 396-400 LID - 10.1002/pan.70112 [doi] AB - BACKGROUND: The American Society of Anesthesiologists Physical Status (ASA-PS) classification system is widely used to classify patient comorbidities prior to surgery and is often used as a marker of perioperative risk. Since its inception in 1941, it has undergone modifications to adapt to changing clinical needs and to improve its reliability. In 2020, a version of the ASA-PS was released with pediatric-specific case examples. AIM: To explore inter-rater reliability in ASA-PS scoring in the pediatric population. METHODS: This single-center retrospective study evaluated the assigned ASA-PS scores of 364 patients at a quaternary pediatric hospital. Each patient was assigned three ASA-PS scores-one by the case anesthetist and one each by two independent consultant anesthetists using the ASA guidance issued in 2020. Concordance was measured between the assigned scores, and potential reasons for discordant scores were identified. RESULTS: There was strong concordance of ASA-PS scores between the two independently scoring anesthetists (weighted kappa coefficient 0.76), but only moderate concordance between the case anesthetist and the independent anesthetists (weighted kappa coefficient 0.5). Where there was a discrepancy, the case anesthetist had usually underscored the ASA-PS by 1 point. Patients who had symptomatic cardiac disease, abnormal body mass index for age, an oncologic state, brain malformation, or a difficult airway were more likely to be assigned an incorrect ASA-PS score. CONCLUSIONS: Moderate inter-rater variability exists in the assignment of ASA-PS scores in the pediatric population, and many patients are being underscored. Use of ASA guidance to assist with pediatric ASA-PS scoring improves the reliability of scoring and may improve accurate communication of perioperative risk. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Liu, Lucy AU - Liu L AUID- ORCID: 0000-0003-1170-3919 AD - Department of Anaesthesia, Great Ormond Street Hospital for Children, London, UK. AD - Department of Anaesthesia, University College Hospital, London, UK. FAU - Foote, Lucy AU - Foote L AD - Department of Anaesthesia, Great Ormond Street Hospital for Children, London, UK. FAU - Kolyvaki, Evgenia AU - Kolyvaki E AD - Department of Anaesthesia, Charing Cross Hospital, London, UK. FAU - Lyons, Craig AU - Lyons C AD - Department of Anaesthesia, Great Ormond Street Hospital for Children, London, UK. AD - Department of Anaesthesia, Galway University Hospitals, Galway, Ireland. FAU - Laycock, Helen AU - Laycock H AD - Department of Anaesthesia, Great Ormond Street Hospital for Children, London, UK. LA - eng PT - Journal Article DEP - 20260108 PL - France TA - Paediatr Anaesth JT - Paediatric anaesthesia JID - 9206575 SB - IM MH - Humans MH - Child MH - Reproducibility of Results MH - Female MH - Retrospective Studies MH - Child, Preschool MH - Infant MH - Male MH - Pediatric Anesthesia MH - Adolescent MH - Anesthesiologists MH - United States MH - Societies, Medical MH - *Health Status MH - Infant, Newborn EDAT- 2026/01/08 07:13 MHDA- 2026/03/10 07:00 CRDT- 2026/01/08 04:50 PHST- 2025/12/04 00:00 [revised] PHST- 2025/05/06 00:00 [received] PHST- 2025/12/16 00:00 [accepted] PHST- 2026/03/10 07:00 [medline] PHST- 2026/01/08 07:13 [pubmed] PHST- 2026/01/08 04:50 [entrez] AID - 10.1002/pan.70112 [doi] PST - ppublish SO - Paediatr Anaesth. 2026 Apr;36(4):396-400. doi: 10.1002/pan.70112. Epub 2026 Jan 8. PMID- 41502821 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260522 LR - 20260919 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - Establishing percentiles for phase angle, skeletal muscle mass index, and muscle-to-fat ratio in Brazilian adolescents: a bioelectrical impedance analysis study with 59,000 participants. PG - 1686037 LID - 10.3389/fnut.2025.1686037 [doi] LID - 1686037 AB - BACKGROUND: Reliable normative references for adolescent body composition are essential for screening and surveillance, yet Brazilian data at national scale remain scarce and heterogeneous across methods and devices. OBJECTIVES: To generate age- and sex-specific reference curves for phase angle (PhA), skeletal muscle mass index (SMMI), and muscle-to-fat ratio (MFR) in Brazilian adolescents, and to present device- dependent body fat percentage (%BF) percentiles as secondary, interpretation- cautioned outputs. METHODS: We analyzed a frozen, de-identified extract of routine multi- frequency bioimpedance assessments (10.00-19.99 years) spanning all five Brazilian macro-regions and multiple recruitment contexts (schools, clinics/primary care, private practices, gyms/fitness centers, community programs). The extract is produced by a vendor privacy/QA pipeline compliant with LGPD; upstream cleaning logs are not accessible to the authors. Prespecified plausibility and deduplication rules (anthropometry and impedance thresholds; robust BIVA on R/H and Xc/H) were re- applied and yielded no additional exclusions. Sex-specific age curves were modeled with GAMLSS (LMS) to estimate smoothed percentiles (P3, P10, P25, P50, P75, P90, P97). %BF, derived from a proprietary embedded equation, is reported as secondary. RESULTS: The analytic cohort comprised 59,000 adolescents from all macro-regions and diverse contexts. Median PhA, SMMI, and MFR increased with age in boys and showed the expected attenuated or plateauing patterns in girls across mid- to late adolescence. Percentile spreads widened with age for muscle-related indices, indicating growing interindividual variability. Device-dependent %BF percentiles exhibited age- and sex- specific trajectories consistent with physiological expectations but should be interpreted with caution pending external validation. CONCLUSIONS: We provide national reference percentiles for PhA, SMMI, and MFR that are immediately useful for clinical and public- health applications and less sensitive to device-specific assumptions. %BF curves are offered as secondary and require independent validation against a criterion method before routine use. Future work should confirm regional representativeness and cross-device portability. CI - Copyright (c) 2025 Teixeira, Motta, Sa Filho, Oliveira Silva, Leonardo and Lopes-Martins. FAU - Teixeira, Fernando Guimaraes AU - Teixeira FG AD - Programa de Pos-Graduacao em Ciencias do Movimento Humano e Reabilitacao, Universidade Evangelica de Goias-UniEvangelica, Anapolis, Brazil. FAU - Motta, Flavio Andrade Amaral AU - Motta FAA AD - Hospital do Cancer de Muriae-Fundacao Cristiano Varella, Muriae, Brazil. FAU - de Sa Filho, Alberto Souza AU - de Sa Filho AS AD - Programa de Pos-Graduacao em Ciencias do Movimento Humano e Reabilitacao, Universidade Evangelica de Goias-UniEvangelica, Anapolis, Brazil. FAU - de Oliveira Silva, Iranse AU - de Oliveira Silva I AD - Programa de Pos-Graduacao em Ciencias do Movimento Humano e Reabilitacao, Universidade Evangelica de Goias-UniEvangelica, Anapolis, Brazil. FAU - Leonardo, Patricia Sardinha AU - Leonardo PS AD - Faculdade de Medicina, Afya Centro Universitario Itaperuna, Itaperuna, Brazil. FAU - Lopes-Martins, Rodrigo Alvaro Brandao AU - Lopes-Martins RAB AD - Hospital do Cancer de Muriae-Fundacao Cristiano Varella, Muriae, Brazil. AD - Faculdade de Medicina, Afya Centro Universitario Itaperuna, Itaperuna, Brazil. AD - Programa de Pos-Graduacao em Bioengenharia, Universidade Brasil, Sao Paulo, Brazil. LA - eng PT - Journal Article DEP - 20251223 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 EIN - Front Nutr. 2026 May 05;13:1863696. doi: 10.3389/fnut.2026.1863696. PMID: 42163958 PMC - PMC12771542 OTO - NOTNLM OT - BIA OT - adolescents OT - bioelectrical impedance analysis OT - body composition OT - phase angle OT - reference values COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/08 07:13 MHDA- 2026/01/08 07:14 PMCR- 2025/12/23 CRDT- 2026/01/08 04:38 PHST- 2025/08/14 00:00 [received] PHST- 2025/11/14 00:00 [revised] PHST- 2025/11/17 00:00 [accepted] PHST- 2026/01/08 07:13 [pubmed] PHST- 2026/01/08 07:14 [medline] PHST- 2026/01/08 04:38 [entrez] PHST- 2025/12/23 00:00 [pmc-release] AID - 10.3389/fnut.2025.1686037 [doi] PST - epublish SO - Front Nutr. 2025 Dec 23;12:1686037. doi: 10.3389/fnut.2025.1686037. eCollection 2025. PMID- 41501781 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260627 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jan 7 TI - Association between ultra-processed food consumption and odds of depression, stress, and anxiety in adolescent girls: a cross-sectional study. PG - 457 LID - 10.1186/s12889-025-26167-6 [doi] LID - 457 AB - BACKGROUND AND AIM: Mental disorders, including depression, anxiety, and stress, disproportionately affect adolescent girls, with dietary patterns emerging as modifiable risk factors. Ultra-processed food (UPF) consumption, prevalent among adolescents, may exacerbate these conditions. This study examines the association between UPF consumption and mental health outcomes in Iranian female adolescents. METHODS: In this cross-sectional study, 263 female adolescents aged 15-18 years from Tehran, Iran, were assessed. Dietary intake was measured using a validated 168-item food frequency questionnaire, with UPFs classified per the NOVA system and expressed as a percentage of total energy intake. Depression, anxiety, and stress were evaluated using the DASS-21 questionnaire. Multivariable logistic regression models estimated odds ratios (ORs) and 95% confidence intervals (CIs) across UPF consumption tertiles, adjusting for BMI and physical activity. RESULTS: Higher UPF consumption was significantly associated with increased odds of depression, stress, and anxiety. In fully adjusted models, participants in the highest UPF tertile had 3.69 times higher odds of depression (95% CI: 1.92-7.10, P trend < 0.001), 2.84 times higher odds of stress (95% CI: 1.49-5.41, P trend = 0.001), and 1.99 times higher odds of anxiety (95% CI: 1.10-3.66, P trend = 0.026) compared to the lowest tertile. CONCLUSION: Greater UPF consumption is associated with elevated odds of depression, stress, and anxiety in adolescent girls, underscoring the need for dietary interventions to mitigate mental health burdens in this vulnerable population. FAU - Jafari, Ali AU - Jafari A AD - Student Research Committee, Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran. FAU - Momenan, Mehrnaz AU - Momenan M AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Tehrani, Asal Neshatbini AU - Tehrani AN AD - Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. FAU - Behrouz, Vahideh AU - Behrouz V AD - Department of Nutrition, Faculty of Public Health, Kerman University of Medical Sciences, Kerman, Iran. FAU - Yari, Zahra AU - Yari Z AD - Department of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, West Arghavan St. Farahzadi Blvd., Sharake Qods, Tehran, Iran. zahrayari_nut@yahoo.com. LA - eng PT - Journal Article DEP - 20260107 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Adolescent MH - *Depression/epidemiology MH - *Anxiety/epidemiology MH - *Stress, Psychological/epidemiology MH - Food, Processed MH - Iran/epidemiology MH - *Fast Foods/statistics & numerical data MH - Risk Factors PMC - PMC12871020 OTO - NOTNLM OT - Adolescent girls OT - Anxiety OT - Depression OT - Stress OT - Ultra-processed foods COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the principles outlined in the Declaration of Helsinki and received ethical approval from the Ethics Committee of the National Nutrition and Food Technology Research Institute at Shahid Beheshti University of Medical Sciences, Tehran, Iran (ethics approval number 054577). Informed written consent was obtained from all participants prior to their inclusion in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/08 07:12 MHDA- 2026/06/27 16:09 PMCR- 2026/01/07 CRDT- 2026/01/08 00:02 PHST- 2025/05/22 00:00 [received] PHST- 2025/12/30 00:00 [accepted] PHST- 2026/06/27 16:09 [medline] PHST- 2026/01/08 07:12 [pubmed] PHST- 2026/01/08 00:02 [entrez] PHST- 2026/01/07 00:00 [pmc-release] AID - 10.1186/s12889-025-26167-6 [pii] AID - 26167 [pii] AID - 10.1186/s12889-025-26167-6 [doi] PST - epublish SO - BMC Public Health. 2026 Jan 7;26(1):457. doi: 10.1186/s12889-025-26167-6. PMID- 41500800 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260813 IS - 1468-330X (Electronic) IS - 0022-3050 (Print) IS - 0022-3050 (Linking) VI - 97 IP - 4 DP - 2026 Mar 13 TI - Telomere length as a marker of biological age in paediatric multiple sclerosis. PG - 302-308 LID - 10.1136/jnnp-2025-336736 [doi] AB - BACKGROUND: Increased chronological age correlates with reduced relapse rates and increased disability in multiple sclerosis (MS). Biological age may better capture ageing's impact on MS and might accelerate due to MS itself. Establishing accelerated biological ageing in adults is complicated by normal ageing and comorbidities. Telomere length, a well-recognised biological ageing marker, is shortened in adults with MS and associated with disability. Demonstrating accelerated biological ageing in paediatric-onset MS (POMS) would strengthen the hypothesis that MS drives premature biological ageing. This study aimed to determine if telomere length differs in POMS compared to age-similar healthy controls. METHODS: We performed a cross-sectional case-control study of whole blood samples and clinical data from The US Network of Pediatric MS Centers. Real-time quantitative PCR measured telomere length, expressed as a telomere to somatic DNA ratio (T/S ratio). T/S ratio was compared between cases and age-similar healthy controls using multivariate regression analysis adjusting for chronological age, sex, race, ethnicity, tobacco exposure, socioeconomic status and body mass index. RESULTS: We analysed 300 POMS cases and 200 controls. The unadjusted mean T/S ratios were 1.66 (SD 0.32) for cases and 1.71 (SD 0.29) for controls (mean difference -0.05, 95% CI -0.10 to 0.01, p=0.08). After adjusting for key covariables with face validity, POMS participants had a mean 0.086 shorter T/S ratio than controls (95% CI 0.015 to 0.157, p=0.018). CONCLUSIONS: POMS participants demonstrated shorter telomeres than age-similar controls in a multivariable model adjusting for sociodemographic variables, suggesting that MS may contribute to accelerated biological ageing. CI - (c) Author(s) (or their employer(s)) 2026. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Jacques, Kayla AU - Jacques K AUID- ORCID: 0009-0006-3841-6142 AD - Department of Neurosciences, University of California San Diego, La Jolla, California, USA. FAU - Race, Jonathan AU - Race J AD - Pediatrics, The University of Utah, Salt Lake City, Utah, USA. FAU - Goyne, Christopher AU - Goyne C AD - Department of Neurosciences, University of California San Diego, La Jolla, California, USA. FAU - Fair, Ashley AU - Fair A AD - Department of Neurosciences, University of California San Diego, La Jolla, California, USA. AD - Boston University, Boston, Massachusetts, USA. FAU - Schuette, Allison AU - Schuette A AD - Pediatrics, The University of Utah, Salt Lake City, Utah, USA. FAU - Yang, Jennifer H AU - Yang JH AD - Department of Neurosciences, University of California San Diego, La Jolla, California, USA. FAU - Caillier, Stacy AU - Caillier S AD - University of California San Francisco, San Francisco, California, USA. FAU - Aaen, Gregory Scott AU - Aaen GS AUID- ORCID: 0000-0002-0408-2053 AD - Loma Linda University, Loma Linda, California, USA. FAU - Abrams, Aaron AU - Abrams A AUID- ORCID: 0000-0002-4607-5740 AD - Neurology, Cleveland Clinic, Cleveland, Ohio, USA. FAU - Benson, Leslie AU - Benson L AD - Neurology, Childrens Hospital Boston, Boston, Massachusetts, USA. FAU - Casper, T Charles AU - Casper TC AD - Pediatrics, The University of Utah, Salt Lake City, Utah, USA. FAU - Chitnis, Tanuja AU - Chitnis T AD - Harvard Medical School, Boston, Massachusetts, USA. FAU - Gorman, Mark P AU - Gorman MP AD - Childrens Hospital Boston, Boston, Massachusetts, USA. FAU - Lotze, Tim AU - Lotze T AD - Baylor College of Medicine, Houston, Texas, USA. FAU - Krupp, Lauren AU - Krupp L AUID- ORCID: 0000-0001-7003-807X AD - Pediatric MS Center, NYU Langone Health, New York, New York, USA. FAU - Mar, Soe AU - Mar S AD - Department of Neurology, Washington University in Saint Louis, St. Louis, Missouri, USA. FAU - Ness, Jayne AU - Ness J AD - University of Alabama at Birmingham, Birmingham, Alabama, USA. FAU - Rensel, Mary AU - Rensel M AD - Cleveland Clinic, Cleveland, Ohio, USA. FAU - Rodriguez, Moses AU - Rodriguez M AD - Neurology, Mayo Clinic Rochester, Rochester, Minnesota, USA. AD - Mayo Clinic, Rochester, Minnesota, USA. FAU - Rose, John AU - Rose J AD - University of Utah Health, Salt Lake City, Utah, USA. FAU - Schreiner, Teri AU - Schreiner T AD - Department of Neurology, University of Colorado, Aurora, Colorado, USA. FAU - Tillema, Jan-Mendelt AU - Tillema JM AD - Mayo Clinic, Rochester, Minnesota, USA. FAU - Waldman, Amy AU - Waldman A AD - The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FAU - Wheeler, Yolanda AU - Wheeler Y AUID- ORCID: 0000-0003-1391-4496 AD - Department of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA. FAU - Oksenberg, Jorge AU - Oksenberg J AD - University of California San Francisco, San Francisco, California, USA. FAU - Lin, Jue AU - Lin J AD - University of California San Francisco, San Francisco, California, USA. FAU - Waubant, Emmanuelle AU - Waubant E AD - University of California San Francisco, San Francisco, California, USA. FAU - Graves, Jennifer S AU - Graves JS AD - Department of Neurosciences, University of California San Diego, La Jolla, California, USA jgraves@ucsd.edu. LA - eng GR - K12 NS098482/NS/NINDS NIH HHS/United States GR - R01 NS071463/NS/NINDS NIH HHS/United States PT - Journal Article DEP - 20260313 PL - England TA - J Neurol Neurosurg Psychiatry JT - Journal of neurology, neurosurgery, and psychiatry JID - 2985191R RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Male MH - Case-Control Studies MH - *Multiple Sclerosis/genetics MH - Cross-Sectional Studies MH - Child MH - *Aging/genetics MH - *Telomere MH - Adolescent MH - Biomarkers PMC - PMC13292612 MID - NIHMS2183613 OTO - NOTNLM OT - GENETICS OT - MULTIPLE SCLEROSIS OT - NEUROIMMUNOLOGY OT - PAEDIATRIC NEUROLOGY COIS- Competing interests: MR has served as a speaker or consultant for Serono, Novartis, Genentech, Genzyme, Horizon, TG Therapeutics, Bristol Myers Squibb, Cycle and Sanofi, and has received funding from the National MS Society and Roche for research. EW has received institutional funding for research from the NIH, DoD, Race to Erase MS and NMSS, has received payment for lectures with NeurologyLive and Advanced Curriculum and has served on the advisory board for BMS and Roche. LK has received institutional funding for research from Biogen, Novartis, NIH, NMSS, consulting fees from F Hoffman/LaRoche, Biogen, WebMD/Medscape, Ebix, Gerson Lehrman, honouraria payment from BMS, expert testimony payment from MCIC Vermont, Kaufman Borgeest & Ryan LLP (KBR, LLP) and Sedgwick CMS, Inc, meeting attendance support from BMS/Celgene, has served on the advisory board for Biogen, Novartis and Genentech, has had leadership roles with the International Paediatric MS Study Group, US Network of Paediatric MS Centres, iWiMS and IMSCOGS. JHY has received grant funding from the NIH, consulting fees from Kyowa Kirin, payment for speaking fees from UCB, personal honouraria from the American College of Rheumatology and support for meeting attendance from the NIH. TS has received support for meeting attendance from Hoffman La Roche and participates on the advisory board for Biogen. JR has received grant funding from NMSS, Biogen, PCORI/NIH, Guthy Jackson Charitable Foundation and The VA. TC is supported by grant funding from NIH, NMSS, Massachusetts Life Sciences Center, DoD, Novartis Pharmaceuticals Corporation, Tiziana Therapeutics, Wesley Clover International and Genentech, Inc. Celgene Corp, Sumaira Foundation, Brainstorm Cell Therapeutics, Bristol Myers Squibb, EMD Serono, I-Mab Biopharma, Mallinckrodt ARD, Octave Bioscience, Sanofi and Genzyme; she has received consulting fees (payment made to the institution) from Genentech, Inc., Janssen Research & Development, LLC., Novartis Pharmaceuticals Corporation and Siemens Healthcare Diagnostics Inc., Banner Life Sciences, Biogen, Bristol Myers Squibb, Octave Bioscience, Sandoz, Siemens, TG Therapeutics, UCB and Vida Ventures; payment or honouraria for lectures, presentations, speakers bureaus, manuscript writing or educational events was received from Genentech, Inc., MJH Life Sciences, Prime Education, LLC, and Novartis Pharmaceuticals Corporation; she participates on a Data Safety Monitoring Board or Advisory Board for Bristol Myers Squibb, Genentech, Inc., Novartis Pharmaceuticals Corporation, Octave Bioscience, Inc., Roche, Sanofi US Services, Inc. JSG has received grant funding from Octave Biosciences and Sanofi. EDAT- 2026/01/08 00:27 MHDA- 2026/03/14 00:31 PMCR- 2026/06/24 CRDT- 2026/01/07 21:13 PHST- 2025/05/20 00:00 [received] PHST- 2025/10/26 00:00 [accepted] PHST- 2026/03/14 00:31 [medline] PHST- 2026/01/08 00:27 [pubmed] PHST- 2026/01/07 21:13 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - jnnp-2025-336736 [pii] AID - 10.1136/jnnp-2025-336736 [doi] PST - epublish SO - J Neurol Neurosurg Psychiatry. 2026 Mar 13;97(4):302-308. doi: 10.1136/jnnp-2025-336736. PMID- 41500637 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260625 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 1 DP - 2026 Jan 6 TI - Schulthess Clinic Zurich Shoulder Instability Registry: a local registry for multimodal data collection and enhanced care. PG - e105453 LID - 10.1136/bmjopen-2025-105453 [doi] LID - e105453 AB - PURPOSE: The Shoulder Instability Registry (SIR) was established in 2019 to systematically capture and monitor outcomes following surgical treatment of shoulder instability (SI). The aim of this cohort profile is to describe the purpose, design, data structure and baseline characteristics of the SIR, and to outline how the registry supports longitudinal assessment of safety, functional recovery, quality of life and patient-reported outcomes after surgical treatment of SI. PARTICIPANTS: The registry includes all patients treated surgically for SI. Data collection includes medical history of instability, surgical techniques and intraoperative findings. Clinical assessments include range of motion, instability-specific tests, hyperlaxity signs, Constant Score, subjective shoulder value and SI-specific scores such as the ROWE Score and the Western Ontario Shoulder Instability Index. Radiological evaluations included initial and follow-up imaging via X-rays and CT to assess bony lesions and SI-related arthropathy, as well as MRI for soft tissue injuries. Data are documented preoperatively, at 6 months and at 24 months postoperatively. Although the SIR is an observational cohort rather than a randomised clinical trial, treatment effectiveness is evaluated through longitudinal changes in validated patient-reported outcomes, clinical performance measures and imaging findings. FINDINGS TO DATE: Between January 2019 and December 2024, 668 patients have been registered (mean age 31 years, 82% men, mean body mass index of 25). According to the American Association of Anesthesiology (ASA) Classification, 66% of patients were classified as ASA I, 33% as ASA II and only 1% as ASA III. 69% of admissions were due to accidents and 31% due to illness. Mean surgery duration was 75 min, and the median hospital stay was 2 days. 38% of patients were insured privately and had general insurance in 62%. 85% of cases were treated arthroscopically, and 15% were treated openly. Baseline clinical scores showed a mean Constant Score of 77 points, mean subjective shoulder value of 49%, mean ROWE Score of 46 points and mean Western Ontario Shoulder Instability Index of 53. Based on Gerber's classification, 68% of cases were type B2, 29% B3, 2% B5 and fewer than 2% were classified as B4 or B1. 85% of cases suffered from anterior instability, while only 13% experienced posterior instability, the remaining 2% showed multidirectional instability. Among posterior cases, Moroder's classification identified 58% as type B2, 19% as A2, 7% as A1, 6% as B1, 6% as C1 and 4% as C2. Regarding osteochondral lesions, 20% showed none, 31% showed a glenoid defect, 54% showed a Hill-Sachs lesion and 13% showed a cartilage defect. Scheibel's classification identified glenoid defects as type 3a in 38% of cases, type 2 in 24%, type 1a in 13% of cases, type 3b in 11%, type 1b in 8% and type 1c in 5% of cases. Positive Gagey and Walch signs were observed in 29% and 27% of cases, respectively. Dislocations presented as primary events in 24% of cases, while 76% were recurrent. Surgical interventions included 459 (70%) Bankart repairs, 6 Bankart plus repairs (<1%) and 108 (16%) Remplissage procedures for soft tissue stabilisation. Bony reconstructions included 52 fragment fixations (8%), 41 coracoid transfers (6%) and 87 iliac crest bone grafts (13%). Additional pathologies were addressed in 533 cases (81%), while 38 cases required revision surgery. FUTURE PLANS: We will continue prospectively enrolling and monitoring patients that receive surgical treatment of SI. There are no current plans to halt the data collection in the near future, thereby consistently increasing the number of patients in the registry. A larger availability of data will additionally allow us to apply machine learning modelling and develop risk-prediction tools with the goal of aiding surgical decision making. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Schneller, Tim AU - Schneller T AUID- ORCID: 0009-0007-6949-9849 AD - Department for Shoulder and Elbow Surgery, Schulthess Klinik, Zurich, Switzerland tim.schneller@kws.ch. FAU - Delliehausen, Nadja AU - Delliehausen N AD - Department for Shoulder and Elbow Surgery, Schulthess Klinik, Zurich, Switzerland. FAU - Brune, Daniela AU - Brune D AD - Department for Shoulder and Elbow Surgery, Schulthess Klinik, Zurich, Switzerland. FAU - Bohm, Elisabeth AU - Bohm E AD - Department for Shoulder and Elbow Surgery, Schulthess Klinik, Zurich, Switzerland. FAU - Moroder, Philipp AU - Moroder P AD - Department for Shoulder and Elbow Surgery, Schulthess Klinik, Zurich, Switzerland. FAU - Lazaridou, Asimina AU - Lazaridou A AD - Department for Shoulder and Elbow Surgery, Schulthess Klinik, Zurich, Switzerland. AD - Department of Anesthesiology, Brigham and Women's Hospital, Boston, Massachusetts, USA. FAU - Scheibel, Markus AU - Scheibel M AD - Department for Shoulder and Elbow Surgery, Schulthess Klinik, Zurich, Switzerland. AD - Center for Musculoskeletal Surgery, Charite - Universitatsmedizin Berlin, Berlin, Germany. LA - eng PT - Journal Article DEP - 20260106 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Registries MH - *Joint Instability/surgery MH - Adult MH - Male MH - *Shoulder Joint/surgery/physiopathology/diagnostic imaging MH - Female MH - Patient Reported Outcome Measures MH - Young Adult MH - Adolescent MH - Range of Motion, Articular MH - Treatment Outcome MH - Middle Aged MH - Data Collection MH - Quality of Life PMC - PMC12778285 OTO - NOTNLM OT - Patient Reported Outcome Measures OT - REGISTRIES OT - Shoulder COIS- Competing interests: MS is a paid consultant of and receives royalties from Stryker. PM is a paid consultant of and receives royalties from Arthrex. All other authors have no competing interest to declare. EDAT- 2026/01/08 00:27 MHDA- 2026/01/08 00:28 PMCR- 2026/01/06 CRDT- 2026/01/07 20:43 PHST- 2026/01/08 00:28 [medline] PHST- 2026/01/08 00:27 [pubmed] PHST- 2026/01/07 20:43 [entrez] PHST- 2026/01/06 00:00 [pmc-release] AID - bmjopen-2025-105453 [pii] AID - 10.1136/bmjopen-2025-105453 [doi] PST - epublish SO - BMJ Open. 2026 Jan 6;16(1):e105453. doi: 10.1136/bmjopen-2025-105453. PMID- 41500389 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260625 IS - 1878-1632 (Electronic) IS - 1529-9430 (Linking) VI - 26 IP - 5 DP - 2026 May TI - Is chronic low back pain related to sleep disturbances? A self-organizing maps for unsupervised machine learning-based patient phenotyping. PG - 1014-1024 LID - S1529-9430(26)00003-3 [pii] LID - 10.1016/j.spinee.2026.01.007 [doi] AB - BACKGROUND CONTEXT: Chronic low back pain (CLBP) is a multifactorial condition and a leading cause of disability worldwide. Among the various contributors to symptom persistence, sleep quality has emerged as a critical yet underexplored factor. Evidence suggests a bidirectional relationship between poor sleep and pain intensity, disability, and psychological distress in individuals with CLBP. PURPOSE: To explore the relationship between sleep quality and CLBP using machine learning techniques, specifically the Self-Organizing Map (SOM) algorithm, while accounting for demographic, clinical, psychosocial, and occupational factors. STUDY DESIGN/SETTING: This was a cross-sectional study conducted at Campus Bio-Medico Hospital Foundation in Rome, Italy, between July 2024 and January 2025. PATIENT SAMPLE: The study included 279 adult working patients (aged 18-65) with a clinical diagnosis of CLBP due to degenerative causes, all of whom were candidates for conservative treatment. Patients with cancer, trauma, spinal deformities, or infections were excluded. OUTCOME MEASURES: Pain intensity was assessed using the Visual Analog Scale (VAS), while sleep quality was measured with the Pittsburgh Sleep Quality Index (PSQI), a validated tool capturing various dimensions of sleep disturbance. Disability related to low back pain was evaluated using the Oswestry Disability Index (ODI). Depressive symptoms were identified using the Patient Health Questionnaire-2 (PHQ-2). Functional outcomes included assessment of work capacity through the Work Ability Index (WAI) and activity limitations via the Nordic Musculoskeletal Questionnaire, focusing on how often back pain interfered with usual daily activities. METHODS: Validated questionnaires and anthropometric data were collected. SOM, an unsupervised machine learning algorithm, was applied to detect clusters based on multidimensional patient data. Subsequent k-means clustering was used to define patient subgroups. Statistical comparisons between clusters were performed using Kruskal-Wallis and chi-squared tests. Multiple imputation addressed missing data. RESULTS: A total of 4 distinct patient clusters were identified. Cluster 1 included physically active individuals with moderate pain and no depression. Cluster 2 consisted of highly educated women with sedentary jobs and minimal disability. Cluster 3 showed the worst outcomes: high pain intensity, severe disability, depression, and the poorest sleep quality. Cluster 4, composed entirely of men, showed high work ability, good sleep, low pain, and no depressive symptoms. Poor sleep quality correlated strongly with depressive symptoms, high pain, disability, and reduced work capacity. These associations persisted even when sleep was excluded from clustering inputs, confirming its predictive linkage. CONCLUSIONS: Sleep quality is a key determinant in the clinical profile of CLBP patients. Poor sleep is closely associated with worse pain perception, psychological distress, and functional impairment. SOM analysis revealed hidden patterns not captured by traditional methods. Integrating sleep evaluation into multidisciplinary care models may improve outcomes for CLBP patients. Longitudinal studies are needed to clarify the directionality of these effects. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Petrucci, Giorgia AU - Petrucci G AD - Operative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy. FAU - Russo, Simone AU - Russo S AD - Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers' Compensation Authority (INAIL), Rome, Italy. FAU - Russo, Fabrizio AU - Russo F AD - Operative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy; Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Universita Campus Bio-Medico di Roma, Rome, Italy. Electronic address: fabrizio.russo@policlinicocampus.it. FAU - Vadala, Gianluca AU - Vadala G AD - Operative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy; Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Universita Campus Bio-Medico di Roma, Rome, Italy. FAU - Marchetti, Anna AU - Marchetti A AD - Research Unit of Nursing Palliative Care, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, 00128, Italy; Department of Medicine and Surgery, Research Unit of Nursing Science, University Campus Bio-Medico di Roma, Rome, 00128, Italy. FAU - Piredda, Michela AU - Piredda M AD - Department of Medicine and Surgery, Research Unit of Nursing Science, University Campus Bio-Medico di Roma, Rome, 00128, Italy. FAU - Iavicoli, Sergio AU - Iavicoli S AD - General Directorate for Prevention, Ministry of Health, Rome, Italy. FAU - De Marinis, Maria Grazia AU - De Marinis MG AD - Research Unit of Nursing Palliative Care, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, 00128, Italy; Department of Medicine and Surgery, Research Unit of Nursing Science, University Campus Bio-Medico di Roma, Rome, 00128, Italy. FAU - Papalia, Rocco AU - Papalia R AD - Operative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy; Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Universita Campus Bio-Medico di Roma, Rome, Italy. FAU - Denaro, Vincenzo AU - Denaro V AD - Operative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy. LA - eng PT - Journal Article DEP - 20260105 PL - United States TA - Spine J JT - The spine journal : official journal of the North American Spine Society JID - 101130732 SB - IM MH - Humans MH - *Low Back Pain/complications/etiology MH - Female MH - Adult MH - Male MH - Cross-Sectional Studies MH - Middle Aged MH - *Sleep Wake Disorders/complications MH - *Unsupervised Machine Learning MH - Phenotype MH - *Chronic Pain/complications MH - Pain Measurement MH - Young Adult MH - Sleep Quality MH - Disability Evaluation MH - Clustering Algorithms MH - Aged MH - Adolescent OTO - NOTNLM OT - Chronic low back pain OT - Depression OT - Disability OT - Pain intensity OT - Psychosocial factors OT - Sleep quality OT - Work ability COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/01/08 00:26 MHDA- 2026/04/26 05:13 CRDT- 2026/01/07 19:16 PHST- 2025/07/09 00:00 [received] PHST- 2025/12/03 00:00 [revised] PHST- 2026/01/03 00:00 [accepted] PHST- 2026/04/26 05:13 [medline] PHST- 2026/01/08 00:26 [pubmed] PHST- 2026/01/07 19:16 [entrez] AID - S1529-9430(26)00003-3 [pii] AID - 10.1016/j.spinee.2026.01.007 [doi] PST - ppublish SO - Spine J. 2026 May;26(5):1014-1024. doi: 10.1016/j.spinee.2026.01.007. Epub 2026 Jan 5. PMID- 41499911 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260625 IS - 1872-7727 (Electronic) IS - 0720-048X (Linking) VI - 195 DP - 2026 Feb TI - Acceleration of chemical shift encoding-based water-fat imaging for pancreatic proton density fat fraction mapping in a single breath-hold: Data from the LION study. PG - 112641 LID - S0720-048X(25)00727-2 [pii] LID - 10.1016/j.ejrad.2025.112641 [doi] AB - PURPOSE: With the rising prevalence of obesity and metabolic syndrome, there is an increasing need for noninvasive quantification of pancreatic fat as a marker of metabolic risk. Chemical shift encoding (CSE)-based water-fat separation enables pancreatic proton density fat fraction (PDFF) mapping. This study evaluates techniques for accelerating high-resolution, single-breath-hold PDFF mapping using sparse sampling with compressed sensing with sensitivity encoding (C-SENSE) and a deep learning (DL)-assisted reconstruction algorithm, focusing on reproducibility, precision, and clinical applicability. METHODS: 104 abdominal MRI datasets were obtained from 71 adults (58 % female; age 18-65 years; body mass index (BMI) 30.0-39.9 kg/m(2); without diabetes) enrolled in a lifestyle intervention trial. Imaging was performed at 3 T (Ingenia Elition X, Philips) using two six-echo gradient-echo acquisitions (2 x 2 x 3 mm(3), identical TR/TE/echo spacing). Acceleration factors of R = 6 (16.9 s) and R = 10 (10.3 s) were reconstructed using vendor compressed sensing (C-SENSE6, C-SENSE10); the DL-assisted reconstruction (C-SENSE AI10) was applied only to R = 10 to evaluate denoising of higher-acceleration data. PDFF maps were analyzed using three regional regions of interest (ROIs) (head, body, tail) and whole-pancreas segmentation. RESULTS: A Mean pancreatic PDFF measured with C-SENSE6 was 15.0 [10.9 - 23.0] % at baseline (V1) and 8.2 [7.1 - 11.4] % after one year (V3). Across all reconstructions, PDFF ranged 3.5 - 47.6 %. Strong linearity was observed between C-SENSE10 and C-SENSE AI10 compared with C-SENSE6 (R(2) >/= 0.99). Whole-pancreas analysis showed high reproducibility (intraclass correlation coefficient = 0.87 - 1.00 across methods). The DL-assisted reconstruction reduced map noise compared with conventional C-SENSE10 without affecting PDFF accuracy. CONCLUSION: Accelerated CSE-based pancreatic PDFF mapping enables precise, reproducible, and clinically feasible single-breath-hold fat quantification. The approach provides a robust tool for evaluating pancreatic steatosis in obesity and metabolic disease research. CI - Copyright (c) 2025 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Rupp, Selina AU - Rupp S AD - Institute for Diagnostic and Interventional Radiology, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Han, Jessie AU - Han J AD - Institute for Diagnostic and Interventional Radiology, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Naebauer, Stella Marlene AU - Naebauer SM AD - Institute for Diagnostic and Interventional Radiology, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Weiss, Kilian AU - Weiss K AD - Philips GmbH Market DACH, Hamburg, Germany. FAU - Peeters, Johannes M AU - Peeters JM AD - Philips Healthcare, Best, Netherlands. FAU - Makowski, Marcus M AU - Makowski MM AD - Institute for Diagnostic and Interventional Radiology, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Reik, Anna AU - Reik A AD - Institute for Nutritional Medicine, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Hauner, Hans AU - Hauner H AD - Institute for Nutritional Medicine, School of Medicine and Health, Technical University of Munich, Munich, Germany; Else Kroener-Fresenius-Center of Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany. FAU - Holzapfel, Christina AU - Holzapfel C AD - Institute for Nutritional Medicine, School of Medicine and Health, Technical University of Munich, Munich, Germany; Department of Nutritional, Food and Consumer Sciences, Fulda University of Applied Sciences, Fulda, Germany. FAU - Junker, Daniela AU - Junker D AD - Institute for Diagnostic and Interventional Radiology, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Burian, Egon AU - Burian E AD - Institute for Diagnostic and Interventional Radiology, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Karampinos, Dimitrios C AU - Karampinos DC AD - Institute for Diagnostic and Interventional Radiology, School of Medicine and Health, Technical University of Munich, Munich, Germany; Laboratory of Magnetic Resonance Imaging Systems and Methods, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland; CIBM Center for Biomedical Imaging (CIBM), Lausanne, Switzerland. FAU - Wu, Mingming AU - Wu M AD - Institute for Diagnostic and Interventional Radiology, School of Medicine and Health, Technical University of Munich, Munich, Germany; Department of Radiology, LMU University Hospital, Munich, Germany. Electronic address: mingming.wu@tum.de. LA - eng PT - Journal Article DEP - 20260102 PL - Ireland TA - Eur J Radiol JT - European journal of radiology JID - 8106411 RN - 0 (Protons) SB - IM MH - Humans MH - Female MH - Middle Aged MH - Adult MH - *Magnetic Resonance Imaging/methods MH - Reproducibility of Results MH - *Pancreas/diagnostic imaging MH - Male MH - Aged MH - *Adipose Tissue/diagnostic imaging MH - Breath Holding MH - Adolescent MH - Algorithms MH - Young Adult MH - Protons MH - Image Interpretation, Computer-Assisted/methods OTO - NOTNLM OT - Compressed sensing OT - Obesity OT - Pancreatic fat OT - magnetic resonance imaging (MRI) OT - nonalcoholic fatty pancreas disease (NAFPD) OT - proton density fat fraction (PDFF) COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: DK receives grant support from Philips Healthcare. HH is a member of the scientific advisory board of Oviva AG (Zurich, Switzerland) and CH of 4sigma GmbH (Oberhaching, Germany). HH and CH received speaker honoraria from Novo Nordisk (Copenhagen, Denmark). The other authors declare no conflicts of interest. EDAT- 2026/01/07 19:24 MHDA- 2026/01/24 06:36 CRDT- 2026/01/07 18:01 PHST- 2025/09/05 00:00 [received] PHST- 2025/12/17 00:00 [revised] PHST- 2025/12/31 00:00 [accepted] PHST- 2026/01/24 06:36 [medline] PHST- 2026/01/07 19:24 [pubmed] PHST- 2026/01/07 18:01 [entrez] AID - S0720-048X(25)00727-2 [pii] AID - 10.1016/j.ejrad.2025.112641 [doi] PST - ppublish SO - Eur J Radiol. 2026 Feb;195:112641. doi: 10.1016/j.ejrad.2025.112641. Epub 2026 Jan 2. PMID- 41498679 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260625 IS - 1827-1928 (Electronic) IS - 0022-4707 (Linking) VI - 66 IP - 1 DP - 2026 Jan TI - Injury risk and workload analysis in elite adolescent female volleyball players using machine learning. PG - 72-81 LID - 10.23736/S0022-4707.25.16744-3 [doi] AB - BACKGROUND: This study investigates the key variables influencing injury occurrence in elite-level female volleyball players. It aims to evaluate three hypotheses: (1) the quantification of workload using the "System Training Response" score provides a superior explanation and prediction of injury occurrence compared to traditional methods such as sum or mean; (2) both menses and external workload serve as primary variables that explain injury occurrence; and (3) non-linear models yield better explanatory and predictive capabilities for injury occurrence than linear models. METHODS: Nineteen elite female volleyball players were monitored throughout a 190-day competitive season, during which various training-related parameters were collected. These parameters included internal and external workload quantification and menses data. To analyze and predict injury occurrence, machine learning techniques were employed, with a particular emphasis on Random Forest models. RESULTS: The Random Forest model demonstrated superior performance in describing injury occurrence, achieving an area under the receiver operating characteristic curve of 0.87. Key variables identified as significant contributors to injury occurrence included the players' age, menses status, and the percentage of intense jumps executed. Furthermore, the cross-validation procedure conducted on a reserved portion of the dataset yielded positive results, with an area under the receiver operating characteristic curve of 0.74, indicating a good generalization performance of the model. CONCLUSIONS: The findings of this study suggest that intense training prior to performance may increase the risk of injury, while older players appear to exhibit a lower risk of injury. These insights highlight the importance of tailored training strategies that consider both physiological factors and individual player profiles to mitigate injury risks in elite female volleyball athletes, including the presence or absence of menstruation with associated discomfort, which appears to be a relevant factor. FAU - Bouzigues, Theo AU - Bouzigues T AD - Ecole Normale Superieure de Rennes, Rennes, France - theobouzigues@orange.fr. AD - Movement, Sport and Health Laboratory (EA 1274), UFR APS, University of Rennes2, Rennes, France - theobouzigues@orange.fr. FAU - Candau, Robin AU - Candau R AD - INRAe Center de Montpellier, UMR 866 Dynamique Musculaire et Metabolisme Montpellier, France. FAU - Ayramo, Sami AU - Ayramo S AD - Faculty of Information Technology, University of Jyvaskyla, Jyvaskyla, Finland. FAU - Maurelli, Olivier AU - Maurelli O AD - INRAe Center de Montpellier, UMR 866 Dynamique Musculaire et Metabolisme Montpellier, France. AD - French Federation of Volleyball, Creteil, France. FAU - Prioux, Jacques AU - Prioux J AD - Ecole Normale Superieure de Rennes, Rennes, France. AD - Movement, Sport and Health Laboratory (EA 1274), UFR APS, University of Rennes2, Rennes, France. LA - eng PT - Journal Article PL - Italy TA - J Sports Med Phys Fitness JT - The Journal of sports medicine and physical fitness JID - 0376337 SB - IM MH - Humans MH - *Volleyball/injuries MH - Female MH - *Machine Learning MH - Adolescent MH - Random Forest MH - *Athletic Injuries/epidemiology MH - Predictive Learning Models MH - Risk Factors MH - Risk Assessment MH - Physical Conditioning, Human MH - Prediction Algorithms EDAT- 2026/01/07 13:17 MHDA- 2026/01/07 13:18 CRDT- 2026/01/07 10:16 PHST- 2026/01/07 13:18 [medline] PHST- 2026/01/07 13:17 [pubmed] PHST- 2026/01/07 10:16 [entrez] AID - S0022-4707.25.16744-3 [pii] AID - 10.23736/S0022-4707.25.16744-3 [doi] PST - ppublish SO - J Sports Med Phys Fitness. 2026 Jan;66(1):72-81. doi: 10.23736/S0022-4707.25.16744-3. PMID- 41497340 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260107 LR - 20260109 IS - 1178-2390 (Print) IS - 1178-2390 (Electronic) IS - 1178-2390 (Linking) VI - 18 DP - 2025 TI - Effectiveness of a Precede-Proceed Model-Based Health Promotion Intervention on Evaluating Changes In Mothers' Knowledge of Stunting Prevention in Indonesian Communities. PG - 8249-8256 LID - 10.2147/JMDH.S541443 [doi] AB - INTRODUCTION: Stunting remains a persistent public health challenge in Indonesia, with significant implications for children's long-term health and national development.The PRECEDE-PROCEED Model (PPM) offers a comprehensive framework for designing effective health education interventions, yet its application in community-based stunting prevention in Indonesia remains underexplored. PURPOSE: The purpose of this study was to identify and launch an increase in maternal knowledge before and after providing a health promotion intervention on stunting prevention. PATIENTS AND METHODS: The research method used was a pre-experimental study that used a one-group pre-test and post-test design involving 52 mothers of children under five years in Cimahi, West Java. A 20-item validated questionnaire was administered before and after a structured 90-minute health education session based on the PPM framework. Educational content focused on nutrition, hygiene, immunization, and child stimulation. RESULTS: Data were analyzed using the Wilcoxon Signed-Rank Test due to non-normal score distribution. Research results show participants' mean knowledge score increased significantly from 18.67 (SD = 1.79) to 19.69 (SD = 0.96) post-intervention (p = 0.00006). Most participants (73%) achieved a perfect score after the session, indicating a positive effect of the intervention. Reduced score variability suggests enhanced and more uniform knowledge dissemination. CONCLUSION: A health promotion intervention using the PRECEDE-PROCEED Model effectively improved maternal knowledge of stunting prevention. The participatory and contextualized approach demonstrated strong potential for replication in community health settings across Indonesia. Further studies should explore long-term behavioral outcomes and scalability. RESEARCH LIMITATIONS: Pre-experimental research design without a control group, so no comparison group that does not receive the intervention. The sample size is relatively small and limited to one location. Outcome measurement is only on short-term maternal knowledge. Focus only on maternal knowledge without measuring other aspects related to stunting prevention. CI - (c) 2025 Andriyani et al. FAU - Andriyani, Septian AU - Andriyani S AD - Doctoral Program in Medicine, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia. AD - Department of Nursing, Faculty of Sport and Health Education, Universitas Pendidikan Indonesia, Bandung, West Java, Indonesia. FAU - Sulastri, Afianti AU - Sulastri A AD - Department of Nursing, Faculty of Sport and Health Education, Universitas Pendidikan Indonesia, Bandung, West Java, Indonesia. FAU - Fitriana, Lisna Anisa AU - Fitriana LA AD - Department of Nursing, Faculty of Sport and Health Education, Universitas Pendidikan Indonesia, Bandung, West Java, Indonesia. FAU - Darmawan, Dadang AU - Darmawan D AD - Stikes RS Dustira, Department of Nursing, Bandung, West Java, Indonesia. FAU - Perdani, Agni Laili AU - Perdani AL AUID- ORCID: 0000-0001-7105-1188 AD - Department of Nursing, Faculty of Sport and Health Education, Universitas Pendidikan Indonesia, Bandung, West Java, Indonesia. FAU - Safariah, Triana Dewi AU - Safariah TD AD - Stikes RS Dustira, Department of Nursing, Bandung, West Java, Indonesia. FAU - Malisa, Novi AU - Malisa N AD - Stikes RS Dustira, Department of Nursing, Bandung, West Java, Indonesia. FAU - Putri, Triyana Harlia AU - Putri TH AUID- ORCID: 0000-0002-2250-8089 AD - Department of Nursing, Universitas Tanjungpura, Pontianak, West Kalimantan, Indonesia. FAU - Mediani, Henny Suzana AU - Mediani HS AUID- ORCID: 0000-0001-6960-3692 AD - Department of Pediatric Nursing, Faculty of Nursing, Universitas Padjadjaran, Sumedang, West Java, Indonesia. LA - eng PT - Journal Article DEP - 20251226 PL - New Zealand TA - J Multidiscip Healthc JT - Journal of multidisciplinary healthcare JID - 101512691 PMC - PMC12765699 OTO - NOTNLM OT - health promotion OT - maternal knowledge OT - precede-proceed model OT - public health OT - stunting COIS- The authors report no conflicts of interest in this work. EDAT- 2026/01/07 06:30 MHDA- 2026/01/07 06:31 PMCR- 2025/12/26 CRDT- 2026/01/07 04:48 PHST- 2025/05/19 00:00 [received] PHST- 2025/12/16 00:00 [accepted] PHST- 2026/01/07 06:31 [medline] PHST- 2026/01/07 06:30 [pubmed] PHST- 2026/01/07 04:48 [entrez] PHST- 2025/12/26 00:00 [pmc-release] AID - 541443 [pii] AID - 10.2147/JMDH.S541443 [doi] PST - epublish SO - J Multidiscip Healthc. 2025 Dec 26;18:8249-8256. doi: 10.2147/JMDH.S541443. eCollection 2025. PMID- 41494680 OWN - NLM STAT- MEDLINE DCOM- 20260106 LR - 20260825 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Jan 6 TI - Assessing Associations Between Environmental, Sleep, and Physical Activity Factors and Metabolic Syndrome Risk: Protocol for the FEASible Study. PG - e82034 LID - 10.2196/82034 [doi] LID - e82034 AB - BACKGROUND: FEASible is a cross-sectional observational study that explores women's daily living patterns through wearable devices and home environment sensors to validate the use of physical activity and indoor air quality data as indicators of risk for metabolic syndrome (MetS) and cardiovascular disease. OBJECTIVE: Leveraging transdisciplinary expertise, we implement a low-cost, dense sampling approach among 800 adult women, 60% Hispanic or Latina, with a subgroup of 225 participants opting for neuroimaging to assess MetS-related brain vulnerability. METHODS: Participants residing in Central Texas use a smartwatch and a custom-built air quality sensor to monitor their activities and environment for two weeks. Other variables, such as social determinants of health, medical history, and lifestyle, are reported through surveys. During their initial visit, we gather blood pressure measurements, body composition, and lipid profile information. RESULTS: As of August 2025, a total of 805 participants have completed the eligibility survey, of whom 204 have completed 2 weeks of sensor data collection, showing a diverse participant pool comprising 60% (210/348) Hispanic or Latinas, 39% (135/348) non-Hispanic or Latinas, and 1% (3/348) unknown. Participants are aged 18-40 years, with an average age of 27 years (SD 6 years). The study was funded in May 2023 (National Heart, Lung, and Blood Institute; grant R01HL168374), and data collection began in October 2023, with a projected completion date of May 2028. Ongoing analyses and publication of early cohorts are expected to occur throughout 2026 and 2027, with final analyses and dissemination of results anticipated by the end of the funding period in 2028. CONCLUSIONS: We have established a feasible pipeline to collect data that will help yield valuable insights into MetS risk factors among Latina women, including brain scan magnetic resonance imaging data and environmental exposure measurements. This paper aims to provide a rationale for procedures and case examples from the first year of data collection leading to health risk modeling, thus informing future interventions on MetS, heart disease, and all-cause mortality among Latina women. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/82034. CI - (c)Tania Ramos-Santiago, Elise Huglo, Yanrong Li, Christian Corral, Congyu Wu, Kerry Kinney, Darla Castelli, Andreana Haley. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 06.01.2026. FAU - Ramos-Santiago, Tania AU - Ramos-Santiago T AUID- ORCID: 0009-0005-0770-7417 AD - Department of Psychology, University of Texas at Austin, Austin, TX, United States. FAU - Huglo, Elise AU - Huglo E AUID- ORCID: 0009-0000-7419-8054 AD - Maseeh Department of Civil, Architectural, and Environmental Engineering, University of Texas at Austin, Austin, TX, United States. FAU - Li, Yanrong AU - Li Y AUID- ORCID: 0009-0008-8118-0053 AD - Department of Psychology, University of Texas at Austin, Austin, TX, United States. FAU - Corral, Christian AU - Corral C AUID- ORCID: 0009-0000-5799-6417 AD - Department of Psychology, University of Texas at Austin, Austin, TX, United States. FAU - Wu, Congyu AU - Wu C AUID- ORCID: 0000-0002-6410-1375 AD - Department of Systems Science and Industrial Engineering, Binghamton University, Greater Binghamton, NY, United States. FAU - Kinney, Kerry AU - Kinney K AUID- ORCID: 0000-0003-1126-2172 AD - Maseeh Department of Civil, Architectural, and Environmental Engineering, University of Texas at Austin, Austin, TX, United States. FAU - Castelli, Darla AU - Castelli D AUID- ORCID: 0000-0002-8862-578X AD - Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, Boston, MA, United States. FAU - Haley, Andreana AU - Haley A AUID- ORCID: 0000-0003-1861-7861 AD - Department of Psychology, University of Texas at Austin, Austin, TX, United States. LA - eng GR - R01 HL168374/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260106 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - *Metabolic Syndrome/epidemiology/etiology MH - Female MH - Adult MH - *Exercise/physiology MH - Cross-Sectional Studies MH - Feasibility Studies MH - *Sleep/physiology MH - Texas/epidemiology MH - Young Adult MH - Adolescent MH - Risk Factors MH - Wearable Electronic Devices PMC - PMC12820547 OTO - NOTNLM OT - Latina women's health OT - MetS OT - indoor air quality OT - metabolic health OT - metabolic syndrome OT - physical activity OT - wearable sensors COIS- Conflicts of Interest: None declared. EDAT- 2026/01/07 01:10 MHDA- 2026/01/07 01:11 PMCR- 2026/01/06 CRDT- 2026/01/06 19:53 PHST- 2025/08/07 00:00 [received] PHST- 2025/11/17 00:00 [accepted] PHST- 2025/11/13 00:00 [revised] PHST- 2026/01/07 01:11 [medline] PHST- 2026/01/07 01:10 [pubmed] PHST- 2026/01/06 19:53 [entrez] PHST- 2026/01/06 00:00 [pmc-release] AID - v15i1e82034 [pii] AID - 10.2196/82034 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Jan 6;15:e82034. doi: 10.2196/82034. PMID- 41494358 OWN - NLM STAT- MEDLINE DCOM- 20260305 LR - 20260305 IS - 1096-7206 (Electronic) IS - 1096-7192 (Linking) VI - 147 IP - 3 DP - 2026 Mar TI - Influence of a 12 week at-home resistance exercise program on (13)C-glucose metabolism in patients with metabolic myopathies. PG - 109714 LID - S1096-7192(25)00706-1 [pii] LID - 10.1016/j.ymgme.2025.109714 [doi] AB - BACKGROUND: Metabolic myopathies (MM) are a diverse group of genetic disorders that impair cellular energy metabolism, resulting in exercise intolerance and fatigue. Previous studies have reported benefits of physiotherapy in patients with MM, however, objective assessments of their efficacy remain limited. The (13)C glucose breath test ((13)C-GBT) is a non-invasive measure of glucose metabolism through the detection of (13)CO(2) expelled from the tricarboxylic acid cycle. This study utilizes the in vivo(13)C-GBT assessment pre- and post-therapeutic intervention to evaluate the impact of a supervised 12 wk. at-home resistance training program on patients with MM. OBJECTIVES: The first experiment was to assess the repeatability of the in vivo(13)C-GBT through triplicate study days in healthy controls. The second experiment was to assess (13)C-glucose metabolism in participants with MM pre- and post-therapeutic intervention. DESIGN: Six healthy adult controls (3 F: 3 M) aged 22-29 y, and three adolescent participants (1 F: 2 M) aged 10-18 y with diagnosed MM were recruited. Participants completed up to three study days pre- and post-intervention, consuming a 1.5 mg/kg body weight dose of [U-(13)C(6)] d-glucose, and 1.5 g/kg body weight Trutol(R) glucose beverage. Breath samples collected during the 4 h study day were analyzed for (13)C enrichment with isotope ratio mass spectrometry, and used to calculate rate of glucose oxidation (mg/kg/min). Measured (13)C enrichment was used to calculate the rate of glucose oxidation (mg/kg/min) and interpreted with Area Under the Curve analysis, and determination of maximum rate (C(max)). RESULTS: Repeatability of the (13)C-GBT was confirmed in healthy participants, with average coefficients of variation (CV) being 8.9 % in males and 8.6 % in females at C(max). Among MM participants, exercise intervention increased glucose oxidation 23.5 % in subject MM-01 (F, 14 y), and 9 % in MM-02 (M, 16 y); but decreased -11.7 % in MM-04 (M, 17 y). All subjects showed a marginal increase in lean body mass (2-4 %). CONCLUSIONS: The non-invasive 4 h (13)C-GBT protocol shows potential as a feasible tool for clinicians to monitor glucose utilization due to its low patient burden and good repeatability. Future work should validate the repeatability of the assay in a larger patient population to confirm its translational potential to guide the management of MM patients. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Plant, Kendall AU - Plant K AD - BC Children's Hospital Research Institute, BC Children's Hospital, Vancouver, BC V5Z 4H4, Canada; Department of Pediatrics, The University of British Columbia, Vancouver, BC V6H 3V4, Canada. FAU - Howard, Caoimhe AU - Howard C AD - Division of Biochemical Genetics, BC Children's Hospital, Vancouver, BC V6H 3V4, Canada. FAU - Bourdon, Philippe AU - Bourdon P AD - Department of Kinesiology and Physical Education, McGill University, Montreal, QC H2W 1S4, Canada. FAU - Massarotto, Raffaele J AU - Massarotto RJ AD - Cardiovascular Physiology Laboratory, Faculty of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC V5A 1S6, Canada. FAU - Gamu, Daniel AU - Gamu D AD - BC Children's Hospital Research Institute, BC Children's Hospital, Vancouver, BC V5Z 4H4, Canada; School of Kinesiology, The University of British Columbia, BC V6T 1Z1, Canada. FAU - Gibson, William T AU - Gibson WT AD - BC Children's Hospital Research Institute, BC Children's Hospital, Vancouver, BC V5Z 4H4, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, BC V6H 3N1, Canada. FAU - Stockler, Sylvia AU - Stockler S AD - BC Children's Hospital Research Institute, BC Children's Hospital, Vancouver, BC V5Z 4H4, Canada; Department of Pediatrics, The University of British Columbia, Vancouver, BC V6H 3V4, Canada; Division of Biochemical Genetics, BC Children's Hospital, Vancouver, BC V6H 3V4, Canada. FAU - Brunel-Guitton, Catherine AU - Brunel-Guitton C AD - BC Children's Hospital Research Institute, BC Children's Hospital, Vancouver, BC V5Z 4H4, Canada; Department of Pediatrics, The University of British Columbia, Vancouver, BC V6H 3V4, Canada; Division of Biochemical Genetics, BC Children's Hospital, Vancouver, BC V6H 3V4, Canada. FAU - Elango, Rajavel AU - Elango R AD - BC Children's Hospital Research Institute, BC Children's Hospital, Vancouver, BC V5Z 4H4, Canada; Department of Pediatrics, The University of British Columbia, Vancouver, BC V6H 3V4, Canada; School of Population and Public Health, The University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address: relango@bcchr.ubc.ca. LA - eng PT - Journal Article DEP - 20251229 PL - United States TA - Mol Genet Metab JT - Molecular genetics and metabolism JID - 9805456 RN - IY9XDZ35W2 (Glucose) RN - 0 (Carbon Isotopes) RN - FDJ0A8596D (Carbon-13) SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Adolescent MH - *Glucose/metabolism MH - *Resistance Training/methods MH - Child MH - Carbon Isotopes/metabolism MH - Breath Tests/methods MH - Young Adult MH - *Muscular Diseases/metabolism/therapy MH - Energy Metabolism OTO - NOTNLM OT - (13)C-glucose OT - Breath test OT - Metabolic myopathy OT - Stable isotope OT - Trutol COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Rajavel Elango reports a relationship with Vitaflo USA LLC that includes: funding grants. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/01/07 01:10 MHDA- 2026/03/06 09:06 CRDT- 2026/01/06 18:04 PHST- 2025/10/17 00:00 [received] PHST- 2025/12/08 00:00 [revised] PHST- 2025/12/24 00:00 [accepted] PHST- 2026/03/06 09:06 [medline] PHST- 2026/01/07 01:10 [pubmed] PHST- 2026/01/06 18:04 [entrez] AID - S1096-7192(25)00706-1 [pii] AID - 10.1016/j.ymgme.2025.109714 [doi] PST - ppublish SO - Mol Genet Metab. 2026 Mar;147(3):109714. doi: 10.1016/j.ymgme.2025.109714. Epub 2025 Dec 29. PMID- 41493142 OWN - NLM STAT- MEDLINE DCOM- 20260307 LR - 20260307 IS - 1466-447X (Electronic) IS - 0264-0414 (Linking) VI - 44 IP - 7 DP - 2026 Apr TI - Smart swim goggles accurately measure heart rate during swim training: A criterion validation study. PG - 844-857 LID - 10.1080/02640414.2025.2610787 [doi] AB - Accurately measuring training intensity in swimming remains a challenge due to the limited availability of scientifically validated monitoring devices. The measurement of heart rate (HR), for example, would enable the calculation of HR-based training loads. The FORM Smart Swim 2 goggles measure HR via a temple-mounted optical sensor and enable real-time HR feedback. However, the goggles' HR measurement function has yet to be validated. Twenty-five experienced recreational swimmers simultaneously wore the goggles and a criterion chest-strap (Garmin HRM-Swim) during the completion of an assigned workout. Agreement was assessed at four levels of data aggregation: individual data points, intervals, main-sets, and whole-workouts. Respective mean HR (HR(mean)) from the goggles and criterion chest-strap were 136 +/- 17 bpm and 135 +/- 18 bpm (mean absolute percentage error = 1.0 +/- 1.2%). For HR(mean), concordance correlation was high (intervals: 0.91, 95%CI: 0.87 to 0.94; whole-workouts: 0.99, 95%CI: 0.99 to 1.0), and fixed bias was low (intervals: -0.23 bpm, 95%CI: -1.2 to 0.78 bpm; whole-workouts: -0.24 bpm; 95%CI: -0.94 to 0.46 bpm). Strong agreement was observed between the goggles and criterion chest-strap for HR measurements, particularly for HR(mean). Since HR(mean) serves as the primary input for HR-based training load metrics, the goggles provide valid data for monitoring swim training. FAU - Kits, Aidan AU - Kits A AD - Department of Biomedical Physiology and Kinesiology and Sports Analytics Group, Simon Fraser University Burnaby, BC, Canada. FAU - Chhatre Elder, Neha AU - Chhatre Elder N AD - Department of Biomedical Physiology and Kinesiology and Sports Analytics Group, Simon Fraser University Burnaby, BC, Canada. FAU - Eisenhardt, Dan AU - Eisenhardt D AD - FORM Athletica Inc, Vancouver, BC, Canada. AD - Department of Health Science and Technology, ExerciseTech, Aalborg University Gistrup, Denmark. FAU - Daryoush Hamedani, Yasmin AU - Daryoush Hamedani Y AD - Department of Biomedical Physiology and Kinesiology and Sports Analytics Group, Simon Fraser University Burnaby, BC, Canada. FAU - Hoskinson, Reynald AU - Hoskinson R AD - FORM Athletica Inc, Vancouver, BC, Canada. FAU - Madeleine, Pascal AU - Madeleine P AD - Department of Health Science and Technology, ExerciseTech, Aalborg University Gistrup, Denmark. FAU - Samani, Afshin AU - Samani A AD - Department of Health Science and Technology, ExerciseTech, Aalborg University Gistrup, Denmark. FAU - Kristiansen, Mathias AU - Kristiansen M AD - Department of Health Science and Technology, ExerciseTech, Aalborg University Gistrup, Denmark. FAU - Clarke, David C AU - Clarke DC AUID- ORCID: 0000-0002-1520-5426 AD - Department of Biomedical Physiology and Kinesiology and Sports Analytics Group, Simon Fraser University Burnaby, BC, Canada. LA - eng PT - Journal Article PT - Validation Study DEP - 20260106 PL - England TA - J Sports Sci JT - Journal of sports sciences JID - 8405364 SB - IM MH - Humans MH - *Swimming/physiology MH - *Heart Rate/physiology MH - Male MH - Female MH - Young Adult MH - *Physical Conditioning, Human MH - Adult MH - Adolescent MH - *Fitness Trackers MH - Wearable Electronic Devices MH - Reproducibility of Results OTO - NOTNLM OT - Photoplethysmography OT - fitness trackers OT - swimming OT - training load OT - validation study EDAT- 2026/01/06 19:17 MHDA- 2026/03/07 18:37 CRDT- 2026/01/06 12:33 PHST- 2026/03/07 18:37 [medline] PHST- 2026/01/06 19:17 [pubmed] PHST- 2026/01/06 12:33 [entrez] AID - 10.1080/02640414.2025.2610787 [doi] PST - ppublish SO - J Sports Sci. 2026 Apr;44(7):844-857. doi: 10.1080/02640414.2025.2610787. Epub 2026 Jan 6. PMID- 41493094 OWN - NLM STAT- MEDLINE DCOM- 20260312 LR - 20260312 IS - 1525-6073 (Electronic) IS - 0742-0528 (Linking) VI - 43 IP - 4 DP - 2026 Apr TI - Daytime eating habits and their association with anemia status among Malaysian female university students. PG - 519-528 LID - 10.1080/07420528.2025.2611856 [doi] AB - Anemia remains a significant public health concern, especially among young women. The SCARF (Study to Combat Anemia-Research for Female Students) study examined the association between daytime eating habits and anemia among Malaysian female university students. Using a validated chrono-nutrition questionnaire, meal patterns, dietary habits, and meal regularity were analyzed, while anemia status was determined by hemoglobin levels. Among 674 students, there were 44.4% Malay, 48.8% Chinese, and 3.4% Indian, with a mean age of 21.2 +/- 1.5 y. About 59.3% were anemic, with a mean hemoglobin level of 11.6 +/- 1.3 g/dL. Daytime meal-skipping habits were linked to significantly lower energy (p < 0.038), fat (p < 0.017), and folate intake (p = 0.003). Breakfast skipping was prevalent among anemic students (70%) compared to non-anemic students (61.3%; chi(2) = 5.51, p = 0.019). Irregular breakfast habits significantly increased anemia prevalence (79.8% vs. 20.3%; chi(2) = 5.10, p = 0.024). Lunch skipping three or more times weekly was a significant predictor of anemia, with an odds ratio of 1.62 (95% CI: 1.01-2.43; p = 0.04). These findings underscore the need for university health initiatives to promote regular breakfast and lunch habits, mitigating anemia risks and fostering long-term student health. FAU - Mok, Kai Ting AU - Mok KT AUID- ORCID: 0000-0002-7880-9235 AD - Department of Food Science and Nutrition, UCSI University, Kuala Lumpur, Malaysia. FAU - Kaur, Satvinder AU - Kaur S AUID- ORCID: 0000-0003-0808-9612 AD - Department of Food Science and Nutrition, UCSI University, Kuala Lumpur, Malaysia. FAU - Say, Yee-How AU - Say YH AUID- ORCID: 0000-0002-8554-049X AD - Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Petaling Jaya, Malaysia. FAU - Buhari, Siti Sabariah AU - Buhari SS AUID- ORCID: 0000-0003-3021-4635 AD - Center for Dietetics Studies, Faculty of Health Sciences, Universiti Teknologi MARA, Puncak Alam, Malaysia. FAU - Sivapathy, Shashikala AU - Sivapathy S AD - Department of Food Science and Nutrition, UCSI University, Kuala Lumpur, Malaysia. FAU - Pot, Gerda K AU - Pot GK AUID- ORCID: 0000-0002-0863-4484 AD - Department of Nutritional Sciences, King's College London, London, UK. LA - eng PT - Journal Article DEP - 20260106 PL - England TA - Chronobiol Int JT - Chronobiology international JID - 8501362 RN - 0 (Hemoglobins) SB - IM MH - Humans MH - Female MH - *Feeding Behavior/physiology MH - Malaysia/epidemiology MH - *Students MH - Universities MH - Young Adult MH - *Anemia/epidemiology/physiopathology MH - Adult MH - *Circadian Rhythm/physiology MH - Prevalence MH - Surveys and Questionnaires MH - Cross-Sectional Studies MH - Hemoglobins/metabolism MH - Adolescent MH - Breakfast OTO - NOTNLM OT - Anemia OT - chrono-nutrition OT - daytime eating habits OT - meal skipping OT - young women EDAT- 2026/01/06 19:17 MHDA- 2026/03/12 07:04 CRDT- 2026/01/06 12:29 PHST- 2026/03/12 07:04 [medline] PHST- 2026/01/06 19:17 [pubmed] PHST- 2026/01/06 12:29 [entrez] AID - 10.1080/07420528.2025.2611856 [doi] PST - ppublish SO - Chronobiol Int. 2026 Apr;43(4):519-528. doi: 10.1080/07420528.2025.2611856. Epub 2026 Jan 6. PMID- 41491340 OWN - NLM STAT- MEDLINE DCOM- 20260504 LR - 20260802 IS - 1467-789X (Electronic) IS - 1467-7881 (Linking) VI - 27 IP - 6 DP - 2026 Jun TI - A Systematic Review Identifying Critical Evidence Gaps in Reporting Dietary Change in Randomized Controlled Trials Prescribing Liraglutide, Semaglutide, or Tirzepatide. PG - e70077 LID - 10.1111/obr.70077 [doi] AB - INTRODUCTION: With the growing use of GLP-1/GIP receptor agonist medications, their impact on dietary intake and quality remains unclear. This systematic review examined how randomized controlled trials (RCT) prescribing liraglutide, semaglutide, or tirzepatide assessed and reported dietary intake and quality as outcome measures, alongside weight loss and/or glycemic control, and identified gaps in the use and methodological quality of dietary assessment methods. METHODS: Medline, Embase, Cochrane, Scopus, and CINAHL were systematically searched between January 2008-January 2025 (adults) and January 2014-January 2025 (children/adolescents). The review was registered with the Open Science Framework (DOI: 10.17605/OSF.IO/XPNGY). RESULTS: Forty-three articles from 41 unique RCTs, comprising 50,690 participants (n = 688 children/adolescents, n = 50,002 adults) were included. Except for two studies targeting adults (one published and one unpublished data from an included study), this review found no other studies that assessed or reported dietary intake or changes in diet. Both reported a reduction in the total energy intake and altered macronutrient distribution in the medication plus diet group, although one was not significantly different from medication alone. Quality of assessment methods used was categorized as "poor" and "acceptable," respectively. These results highlight a critical gap in the literature. CONCLUSION: Only 2/41 studies ( approximately 5%) reported or assessed dietary intake or evaluated diet changes secondary to GLP-1/GIP RA medication use. This review highlights a major gap in the evidence requiring urgent attention. More high-quality research, using validated dietary assessment methods as outcome measures in RCTs is needed to understand how these medications impact diet and diet quality, nutrient intake, and chronic disease risk. CI - (c) 2026 World Obesity Federation. FAU - Jansson, Anna K AU - Jansson AK AUID- ORCID: 0000-0001-9039-2033 AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Gomez-Martin, Maria AU - Gomez-Martin M AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Hedin, Linnea AU - Hedin L AUID- ORCID: 0000-0002-5576-5276 AD - Department of Medicine, Huddinge, Karolinska Institute, Stockholm, Sweden. AD - Allied Health Professionals, Karolinska University Hospital, Stockholm, Sweden. FAU - Clarke, Erin D AU - Clarke ED AUID- ORCID: 0000-0001-8250-5990 AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Cross, Victoria AU - Cross V AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Stanford, Jordan AU - Stanford J AUID- ORCID: 0000-0003-3541-8960 AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Taylor, Rachael M AU - Taylor RM AUID- ORCID: 0000-0002-1895-4123 AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Bogl, Leonie H AU - Bogl LH AD - Department of Health Professions, Division of Nutrition and Dietetics, Bern University of Applied Sciences, Bern, Switzerland. FAU - De Vlieger, Nienke AU - De Vlieger N AD - School of Environmental & Life Sciences, College of Engineering, Science & Environment, University of Newcastle, Ourimbah, New South Wales, Australia. FAU - Koochek, Afsaneh AU - Koochek A AD - Department of Food Studies, Nutrition and Dietetics, Uppsala University, Uppsala, Sweden. FAU - Lof, Marie AU - Lof M AUID- ORCID: 0000-0002-2273-4430 AD - Department of Medicine, Huddinge, Karolinska Institute, Stockholm, Sweden. FAU - Asher, Roberta C AU - Asher RC AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Burrows, Tracy AU - Burrows T AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Bucher, Tamara AU - Bucher T AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - Department of Health Professions, Division of Nutrition and Dietetics, Bern University of Applied Sciences, Bern, Switzerland. FAU - Sullivan, Clair AU - Sullivan C AD - Queensland Digital Health Centre, University of Queensland, St Lucia, Queensland, Australia. AD - Metro North Health, Herston, Queensland, Australia. FAU - Nowicka, Paulina AU - Nowicka P AD - Department of Food Studies, Nutrition and Dietetics, Uppsala University, Uppsala, Sweden. FAU - Collins, Clare E AU - Collins CE AUID- ORCID: 0000-0003-3298-756X AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia. LA - eng GR - APP2009340/National Health and Medical Research Council/ GR - APP1173681/National Health and Medical Research Council/ PT - Journal Article PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Systematic Review DEP - 20260105 PL - England TA - Obes Rev JT - Obesity reviews : an official journal of the International Association for the Study of Obesity JID - 100897395 RN - 839I73S42A (Liraglutide) RN - 62340-29-8 (Glucagon-Like Peptides) RN - OYN3CCI6QE (Tirzepatide) RN - 0 (Hypoglycemic Agents) SB - IM MH - Humans MH - *Liraglutide/therapeutic use MH - *Glucagon-Like Peptides/therapeutic use MH - Randomized Controlled Trials as Topic MH - *Tirzepatide/therapeutic use MH - *Hypoglycemic Agents/therapeutic use MH - Child MH - *Diet MH - Adult MH - *Obesity/drug therapy MH - Evidence Gaps OTO - NOTNLM OT - diet quality OT - dietary outcomes OT - glucagon-like peptide-1 agonists OT - nutrition EDAT- 2026/01/06 13:05 MHDA- 2026/05/04 06:32 CRDT- 2026/01/06 11:10 PHST- 2025/10/02 00:00 [revised] PHST- 2025/06/10 00:00 [received] PHST- 2025/12/09 00:00 [accepted] PHST- 2026/05/04 06:32 [medline] PHST- 2026/01/06 13:05 [pubmed] PHST- 2026/01/06 11:10 [entrez] AID - 10.1111/obr.70077 [doi] PST - ppublish SO - Obes Rev. 2026 Jun;27(6):e70077. doi: 10.1111/obr.70077. Epub 2026 Jan 5. PMID- 41489001 OWN - NLM STAT- MEDLINE DCOM- 20260105 LR - 20260107 IS - 1365-277X (Electronic) IS - 0952-3871 (Print) IS - 0952-3871 (Linking) VI - 39 IP - 1 DP - 2026 Feb TI - Food Frequency Questionnaires Validated in Brazil: A Scoping Review. PG - e70190 LID - 10.1111/jhn.70190 [doi] LID - e70190 AB - OBJECTIVE: To map food frequency questionnaires (FFQs) validated for the Brazilian population. METHODS: This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping (PRISMA-ScR) guidelines and the Joanna Briggs Institute (JBI). Studies that validated FFQs specifically for the Brazilian population were included. These instruments assessed the intake of energy, nutrients, foods and food groups. Review articles and studies that did not focus on FFQ validation for Brazil or its populations were excluded. A search of articles published up to June 2025 was conducted in the PubMed/MEDLINE, LILACS, Embase, Web of Science (ISI), Scopus and Google Scholar databases. RESULTS: A total of 69 articles were identified, dating back to the late 1990s: Southeast (n = 35), South (n = 12), Northeast (n = 10), Central-West (n = 4), North (n = 1) and studies covering two or more regions or populations (n = 7). The FFQs were validated in populations of children and adolescents (n = 18), adults and older adults (n = 36) and women (n = 15). These studies differed in terms of food list size, portion size and the number of frequency categories. CONCLUSION: Compiling and disseminating FFQs validated in Brazil will improve their use in clinical practice and provide a valuable resource for designing future research on food consumption. CI - (c) 2026 The Author(s). Journal of Human Nutrition and Dietetics published by John Wiley & Sons Ltd on behalf of British Dietetic Association. FAU - Brito Barros, Acsa Nara A AU - Brito Barros ANA AUID- ORCID: 0000-0002-3658-287X AD - Graduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil. FAU - Felipe, Maria Luisa N AU - Felipe MLN AD - Graduate Program in Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil. FAU - Bezerra, Maria Fernanda S AU - Bezerra MFS AD - Nutrition Undergraduate Course, Federal University of Rio Grande do Norte, Natal, Brazil. FAU - Leite-Lais, Lucia AU - Leite-Lais L AD - Department of Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil. FAU - Pedrosa, Lucia Fatima Campos AU - Pedrosa LFC AD - Graduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil. AD - Graduate Program in Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil. LA - eng GR - 001/Coordination for the Improvement of Higher Education Personnel, Brazil/ PT - Journal Article PT - Scoping Review PL - England TA - J Hum Nutr Diet JT - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JID - 8904840 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Child MH - Female MH - Humans MH - Male MH - Middle Aged MH - Brazil MH - *Diet/statistics & numerical data MH - *Diet Surveys/standards/methods MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - Validation Studies as Topic PMC - PMC12766558 COIS- The authors declare no conflicts of interest. EDAT- 2026/01/05 06:46 MHDA- 2026/01/05 12:47 PMCR- 2026/01/05 CRDT- 2026/01/05 05:44 PHST- 2025/12/12 00:00 [revised] PHST- 2025/10/17 00:00 [received] PHST- 2025/12/24 00:00 [accepted] PHST- 2026/01/05 12:47 [medline] PHST- 2026/01/05 06:46 [pubmed] PHST- 2026/01/05 05:44 [entrez] PHST- 2026/01/05 00:00 [pmc-release] AID - JHN70190 [pii] AID - 10.1111/jhn.70190 [doi] PST - ppublish SO - J Hum Nutr Diet. 2026 Feb;39(1):e70190. doi: 10.1111/jhn.70190. PMID- 41486649 OWN - NLM STAT- MEDLINE DCOM- 20260308 LR - 20260308 IS - 1097-0010 (Electronic) IS - 0022-5142 (Linking) VI - 106 IP - 5 DP - 2026 Mar 30 TI - Eat mindfully, live spiritually, sustain our world. PG - 2870-2887 LID - 10.1002/jsfa.70384 [doi] AB - BACKGROUND: This study investigates the relationship between spirituality and sustainable eating behaviours, addressing a gap in the Italian literature. Although food sustainability is often examined through economic, environmental or health-related lenses, recent research has highlighted the growing importance of ethical and spiritual values in shaping consumer choices. Spirituality, understood as a personal connection with nature, a sense of duty and inner balance, can motivate individuals to adopt more environmentally conscious dietary habits. Based on a modified Norm Activation Model and incorporating spiritual constructs, the research examines if (and how) spirituality aspects affect sustainable consumer behaviours. An online survey was administered to individuals responsible for household grocery decisions, using validated psychometric scales to assess environmental attitudes, ecological identity, spirituality and eating behaviours. Data were analysed through confirmatory factor analysis and hierarchical multiple regression. RESULTS: The findings demonstrate that spiritual dimensions, especially duty orientation and equanimity, positively affect personal norms, which significantly predict sustainable eating behaviours. Additionally, awareness of environmental consequences and a sense of personal responsibility emerged as key mediators. CONCLUSION: The findings suggest that spirituality can serve as a powerful motivational driver for sustainability, supporting more ethical, mindful and low-impact food choices. Educational and policy interventions that recognize and engage with spiritual values may enhance their effectiveness in promoting sustainable food systems. (c) 2026 Society of Chemical Industry. CI - (c) 2026 Society of Chemical Industry. FAU - Palmieri, Nadia AU - Palmieri N AUID- ORCID: 0000-0001-7178-3733 AD - Department of Economics and Legal Studies, University of Naples "Parthenope", Naples, Italy. FAU - Mastellone, Riccardo AU - Mastellone R AD - Department of Economics and Legal Studies, University of Naples "Parthenope", Naples, Italy. FAU - Boccia, Flavio AU - Boccia F AUID- ORCID: 0000-0001-6466-8841 AD - Department of Economics and Legal Studies, University of Naples "Parthenope", Naples, Italy. LA - eng PT - Journal Article DEP - 20260104 PL - England TA - J Sci Food Agric JT - Journal of the science of food and agriculture JID - 0376334 SB - IM MH - Humans MH - Adult MH - Male MH - Female MH - Middle Aged MH - *Spirituality MH - *Feeding Behavior/psychology MH - Young Adult MH - Surveys and Questionnaires MH - Italy MH - Aged MH - Adolescent MH - Consumer Behavior OTO - NOTNLM OT - Italy OT - modified norm activation model OT - spirituality impacts OT - sustainable eating behaviours EDAT- 2026/01/05 06:47 MHDA- 2026/03/08 06:38 CRDT- 2026/01/05 01:24 PHST- 2025/11/19 00:00 [revised] PHST- 2025/08/22 00:00 [received] PHST- 2025/12/02 00:00 [accepted] PHST- 2026/03/08 06:38 [medline] PHST- 2026/01/05 06:47 [pubmed] PHST- 2026/01/05 01:24 [entrez] AID - 10.1002/jsfa.70384 [doi] PST - ppublish SO - J Sci Food Agric. 2026 Mar 30;106(5):2870-2887. doi: 10.1002/jsfa.70384. Epub 2026 Jan 4. PMID- 41485534 OWN - NLM STAT- MEDLINE DCOM- 20260202 LR - 20260413 IS - 1532-3064 (Electronic) IS - 0954-6111 (Linking) VI - 252 DP - 2026 Feb TI - When the noise exceeds the signal: day-to-day variability in spirometry dominates LLN discordance. PG - 108632 LID - S0954-6111(25)00695-X [pii] LID - 10.1016/j.rmed.2025.108632 [doi] AB - Robert A. Rigby, Mikis D. Stasinopoulous, Achim Zeilis, Sanja Stanojevic, Gillian Heller, Fernanda de Bastiani, Thomas Kneib, Andreas Mayr, Reto Stauffer, and Nikolaus Umlauf contend that segmented linear regression (SLR) is inadequate for spirometry reference equations and over-/underdiagnoses abnormality compared with Generalized Additive Models of Location, Scale, and Shape (GAMLSS). Using a refined NHANES 2007-2012 dataset (n=16,596), I reassessed calibration and the lower limit of normal (LLN) discordance with additional analyses. Out-of-sample root mean square error (RMSE) and correlations were essentially identical across approaches, and overall, the prevalence below the LLN differed by <1 percentage point. Ages 5-80 were resampled to the 2020-2024 U.S. Census age structure, and observed below-LLN counts (z<-1.645) were compared with exact 95% binomial bands; most age-sex strata for FEV(1), FVC, and FEV(1)/FVC fell within expected sampling variability, with modest departures mainly in older men. Age-stratified concordance showed 93.5-93.8% normal by both methods and 4.0-4.8% abnormal by both; discordance was uncommon (GAMLSS-only 0.20-0.78%, SLR-only 1.23-1.65%). Estimated week-to-week measurement variability produced LLN flip rates of approximately 3% (FEV(1)), approximately 3.5% (FVC), and approximately 6% (FEV(1)/FVC), exceeding model-driven differences. GAMLSS remains useful, but simpler, transparent regressions can often yield comparable practical interpretation. CI - Copyright (c) 2026 The Author. Published by Elsevier Ltd.. All rights reserved. FAU - Zavorsky, Gerald S AU - Zavorsky GS AD - Department of Physiology and Membrane Biology, University of California at Davis, Davis, CA, 95616, USA. Electronic address: gszavorsky@health.ucdavis.edu. LA - eng PT - Journal Article DEP - 20260102 PL - England TA - Respir Med JT - Respiratory medicine JID - 8908438 SB - IM MH - Humans MH - *Spirometry/methods/standards/statistics & numerical data MH - Male MH - Middle Aged MH - Female MH - Adult MH - Aged MH - Adolescent MH - Child MH - Aged, 80 and over MH - Vital Capacity/physiology MH - Young Adult MH - Forced Expiratory Volume/physiology MH - Reference Values MH - Child, Preschool MH - Nutrition Surveys MH - Linear Models MH - United States/epidemiology OTO - NOTNLM OT - GAMLSS OT - NHANES OT - Piecewise OT - Reproducibility OT - Segmented COIS- Declaration of competing interest G.S. Zavorsky currently serves (2025-2026) on the American Thoracic Society (ATS) Pulmonary Function Testing (PFT) Committee. He was not a member of the ATS PFT Committee during the development and/or ATS endorsement of the Global Lung Function Initiative (GLI) race-specific and race-neutral reference equations using GAMLSS modeling. The author declares no other competing interests. EDAT- 2026/01/05 00:49 MHDA- 2026/02/03 00:27 CRDT- 2026/01/04 19:30 PHST- 2025/12/13 00:00 [received] PHST- 2025/12/31 00:00 [accepted] PHST- 2026/02/03 00:27 [medline] PHST- 2026/01/05 00:49 [pubmed] PHST- 2026/01/04 19:30 [entrez] AID - S0954-6111(25)00695-X [pii] AID - 10.1016/j.rmed.2025.108632 [doi] PST - ppublish SO - Respir Med. 2026 Feb;252:108632. doi: 10.1016/j.rmed.2025.108632. Epub 2026 Jan 2. PMID- 41484877 OWN - NLM STAT- MEDLINE DCOM- 20261005 LR - 20261005 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jan 3 TI - The mediating and moderating roles of physical sub-health in the relationship between family functioning and mental health problems among Chinese adolescents. PG - 430 LID - 10.1186/s12889-025-26094-6 [doi] LID - 430 AB - BACKGROUND: Adolescent mental health is shaped by both family environments and physical well-being. However, the role of physical sub-health, a state of functional imbalance and fatigue prior to diagnosable illness, remains poorly understood in this process. This study examined whether physical sub-health serves both as a psychosomatic pathway and as a vulnerability factor linking family functioning to adolescent mental health. METHODS: A cross-sectional survey was conducted among 647 primary and secondary school students across China. Validated scales were used to assess family functioning, physical sub-health (operationalized based on constitution characteristics), and mental health symptoms. Structural equation modeling (SEM) was employed to examine the mediating role of physical sub-health. Furthermore, latent moderated structural equation modeling (LMS) was applied to test its moderating effect. RESULTS: Physical sub-health significantly mediated the association between family functioning and mental health, with the largest indirect effects observed for qi stagnation (beta = -0.27, 95% CI [-0.36, -0.20]), qi deficiency (beta = -0.13, 95% CI [-0.17, -0.10]), and phlegm dampness (beta = -0.12, 95% CI [-0.15, -0.08]). These findings suggest that functional bodily imbalance may help explain how family stress is related to emotional and behavioral difficulties. In addition, physical sub-health moderated this association, with adolescents showing poorer physical resilience being more susceptible to the detrimental effects of dysfunctional family environments. CONCLUSION: Physical sub-health plays a dual psychosomatic role in how family functioning relates to adolescent mental well-being, acting as both a mechanism and a vulnerability factor. These findings highlight the potential value of integrated public health strategies that combine family support, school-based identification of psychosomatic risk, and routine health promotion to strengthen youth psychosomatic resilience. TRIAL REGISTRATION: The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board (or Ethics Committee) of Ethics Committee of Beijing University of Chinese Medicine (protocol code No: 2023BZYLL1101 and date of approval: 2023.11.10). FAU - Zhang, Yunan AU - Zhang Y AD - School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, China. FAU - Cai, Xuanyi AU - Cai X AD - School of Management, Beijing University of Chinese Medicine, Beijing, 102488, China. FAU - Jiang, Guangxiang AU - Jiang G AD - School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, China. FAU - Xu, Wenjie AU - Xu W AD - School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, China. FAU - Ran, Yu AU - Ran Y AD - School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, China. FAU - Han, Dongran AU - Han D AD - School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, China. handongr@gmail.com. AD - School of Management, Beijing University of Chinese Medicine, Beijing, 102488, China. handongr@gmail.com. FAU - Wen, Hongjuan AU - Wen H AD - School of Management, Changchun University of Traditional Chinese Medicine, Changchun, 130117, China. wenhj@ccucm.edu.cn. FAU - Liu, Yixing AU - Liu Y AD - School of Management, Beijing University of Chinese Medicine, Beijing, 102488, China. yixingliu1987@gmail.com. LA - eng GR - 82205315/National Natural Science Foundation of China (NSFC) Youth Project/ GR - 2022-JYB-JBZR-021/Beijing University of Chinese Medicine/ PT - Journal Article DEP - 20260103 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - Chinese people SB - IM MH - Cross-Sectional Studies MH - *East Asian People/psychology/statistics & numerical data MH - *Family Relations/psychology MH - *Mental Disorders/epidemiology/etiology MH - China/epidemiology MH - Mental Health/ethnology MH - *Adolescent Health MH - *Body Constitution MH - Qi MH - Yin Deficiency/complications/epidemiology/psychology MH - Yang Deficiency/complications/epidemiology/psychology MH - Mediation Analysis MH - Humans MH - Male MH - Female MH - Adolescent MH - Eating PMC - PMC12866022 OTO - NOTNLM OT - Adolescents OT - Family functioning OT - Mediation model OT - Mental health problems OT - Moderation model OT - Physical sub-health COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board (or Ethics Committee) of Ethics Committee of Beijing University of Chinese Medicine (protocol code No: 2023BZYLL1101 and date of approval: 2023.11.10). Written informed consent was obtained from all participants. For participants under 18 years of age, written informed consent was obtained from a parent/legal guardian, and assent (or electronic informed consent, as applicable) was obtained from the adolescents prior to participation. Participation was entirely voluntary, and adolescents and their guardians were informed that they could withdraw from the study at any time without any negative consequences. All procedures were conducted in accordance with relevant guidelines and regulations (e.g., the Declaration of Helsinki). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/04 06:36 MHDA- 2026/06/27 12:38 PMCR- 2026/01/03 CRDT- 2026/01/04 02:23 PHST- 2025/10/21 00:00 [received] PHST- 2025/12/22 00:00 [accepted] PHST- 2026/06/27 12:38 [medline] PHST- 2026/01/04 06:36 [pubmed] PHST- 2026/01/04 02:23 [entrez] PHST- 2026/01/03 00:00 [pmc-release] AID - 10.1186/s12889-025-26094-6 [pii] AID - 26094 [pii] AID - 10.1186/s12889-025-26094-6 [doi] PST - epublish SO - BMC Public Health. 2026 Jan 3;26(1):430. doi: 10.1186/s12889-025-26094-6. PMID- 41484782 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260702 IS - 1746-4358 (Electronic) IS - 1746-4358 (Linking) VI - 21 IP - 1 DP - 2026 Jan 2 TI - Poor agreement between methods used in population studies to estimate the volume of human milk consumed: a Bland-Altman analysis. PG - 19 LID - 10.1186/s13006-025-00786-6 [doi] LID - 19 AB - BACKGROUND: Measuring the volume of human milk consumed by infants is essential for understanding infant feeding patterns, and their impact on long-term nutrition and health. The study aimed to evaluate the agreement and quantify biases among three methods used to quantify the volume of human milk among children on partial breastfeeding up to 33 months of age. METHODS: A cross-sectional, observational study was conducted between November and December 2022, with socially vulnerable children in the Federal District, Brazil. Dietary intake was assessed using two non-consecutive 24-hour recalls. Human milk volume was estimated using three methods: age/dose-to-mother (DTM), age/partial feeding, and age/feeding. Pearson's correlation coefficient was used to assess associations between methods. Bland-Altman analysis was applied to evaluate agreement between estimates by each method. Statistical significance was set at 5%. RESULTS: Eighty children were evaluated (mean age of 19 months; SD = 6.12), including 15 aged 7-12 months, and 65 aged 13-33 months. Among children aged 7-12 months, moderate and statistically significant correlations were observed between age/DTM x age/partial feeding (r = 0.544, p = 0.02) and between age/partial feeding x age/feeding (r = 0.649, p = < 0.001). The correlation between age/DTM and age/feeding was weak and not statistically significant (r = 0.309, p = 0.097). Most individual estimates fell within the limits of agreement. However, the age/DTM method yielded higher estimated of human milk volume - mean of 321 g/day (95% CI 273, 368) and 333 g/day (95% CI 273, 393) more than the age/feeding and age/partial feeding, respectively. The agreement between methods decreased as estimated milk volume increased. CONCLUSIONS: Although moderate positive correlations were observed among the methods, the age/partial feeding and age/feeding approaches demonstrated the highest level of agreement. No consistent agreement was found between the age/DTM method and the other two approaches. FAU - Lima Cavalcanti, Amanda de Araujo AU - Lima Cavalcanti AA AD - Graduate Program in Human Nutrition, University of Brasilia, Federal District, Brasilia, Brazil. amandanutri06@gmail.com. FAU - Goncalves, Vivian Siqueira Santos AU - Goncalves VSS AD - Graduate Program in Public Health, University of Brasilia, Federal District, Brasilia, Brazil. FAU - Pizato, Nathalia AU - Pizato N AD - Graduate Program in Human Nutrition, University of Brasilia, Federal District, Brasilia, Brazil. AD - Department of Nutrition, Faculty of Health Sciences, University of Brasilia, Federal District, Brasilia, Brazil. FAU - Patriota, Erika Soares de Oliveira AU - Patriota ESO AD - Graduate Program in Public Health, University of Brasilia, Federal District, Brasilia, Brazil. FAU - Guimaraes, Beatriz de Andrade E AU - Guimaraes BAE AD - Department of Nutrition, Faculty of Health Sciences, University of Brasilia, Federal District, Brasilia, Brazil. FAU - Coutinho, Isabela Mendes AU - Coutinho IM AD - Department of Nutrition, Faculty of Health Sciences, University of Brasilia, Federal District, Brasilia, Brazil. FAU - da Costa, Teresa Helena Macedo AU - da Costa THM AD - Graduate Program in Human Nutrition, University of Brasilia, Federal District, Brasilia, Brazil. AD - Department of Nutrition, Faculty of Health Sciences, University of Brasilia, Federal District, Brasilia, Brazil. LA - eng PT - Journal Article PT - Observational Study DEP - 20260102 PL - England TA - Int Breastfeed J JT - International breastfeeding journal JID - 101251562 SB - IM MH - Humans MH - *Milk, Human MH - Infant MH - Female MH - Brazil MH - Cross-Sectional Studies MH - *Breast Feeding/statistics & numerical data MH - Child, Preschool MH - Male PMC - PMC12895698 OTO - NOTNLM OT - Breastfeeding OT - Human milk OT - Intake recall OT - Lactation OT - Stable isotopes COIS- Declarations. Ethical approval: The project was approved by the Ethics and Research Committee of the Faculty of Health Sciences of the University of Brasilia (UnB) (CAAE: 32390620.0.0000.0030), and the children's guardians signed the Free and Informed Consent Form (FICF) before the start of data collection. Competing interests: The authors declare no competing interests. EDAT- 2026/01/04 06:36 MHDA- 2026/06/27 06:43 PMCR- 2026/01/02 CRDT- 2026/01/04 02:00 PHST- 2025/07/26 00:00 [received] PHST- 2025/11/11 00:00 [accepted] PHST- 2026/06/27 06:43 [medline] PHST- 2026/01/04 06:36 [pubmed] PHST- 2026/01/04 02:00 [entrez] PHST- 2026/01/02 00:00 [pmc-release] AID - 10.1186/s13006-025-00786-6 [pii] AID - 786 [pii] AID - 10.1186/s13006-025-00786-6 [doi] PST - epublish SO - Int Breastfeed J. 2026 Jan 2;21(1):19. doi: 10.1186/s13006-025-00786-6. PMID- 41479825 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260102 LR - 20260104 IS - 2220-6124 (Print) IS - 2220-6124 (Electronic) IS - 2220-6124 (Linking) VI - 14 IP - 4 DP - 2025 Dec 25 TI - Risk factors for developing acute kidney injury after heart transplant: A systematic review and meta-analysis. PG - 110791 LID - 10.5527/wjn.v14.i4.110791 [doi] LID - 110791 AB - BACKGROUND: Acute kidney injury (AKI) is a common and serious complication following heart transplantation, significantly impacting patient outcomes and survival rates. AKI after transplantation can lead to prolonged hospital stays, increased morbidity, and even mortality. AIM: To identify and quantify significant risk factors associated with AKI following heart transplantation through a systematic review and meta-analysis. This study aims to distinguish predictive variables that may inform perioperative risk stratification and clinical decision-making. METHODS: Electronic searches on MEDLINE, Google Scholar, ScienceDirect, ClinicalTrials.gov, and Cochrane databases were conducted from inception up till September 1. Included studies were randomized controlled trials, clinical trials, retrospective cohort, and observational studies. Exclusion criteria encompassed studies with pediatric populations, non-English publications, case reports, and studies lacking sufficient data on AKI outcomes. Statistical analysis was performed using RevMan 5.4, reporting dichotomous outcomes as odds ratios (OR) and continuous outcomes as mean differences (MD) with 95% confidence intervals (CI). Quality assessment of the included studies was performed using the New Castle Ottawa Scale. RESULTS: Out of 1345 articles, 13 studies with 3330 patients were included. Significant risk factors included age [overall MD = 2.27 years (95%CI: 0.13 to 4.41)], body mass index (BMI) [MD = 1.42 (95%CI: 0.60 to 2.24)], diabetes [overall OR = 1.47 (95%CI: 1.16 to 1.85)], chronic kidney disease (CKD) [OR = 2.67 (95%CI: 1.73 to 4.14)], chronic obstructive pulmonary disorder (COPD) [OR = 0.49 (95%CI: 0.27 to 0.89)], previous thoracic surgery [(OR) = 1.27, 95%CI: (1.05 to 1.54)], cardio-pulmonary bypass time [(MD) = 17.10, 95%CI: (6.12 to 28.08)], mechanical ventilation duration [(MD) = 30.87 hours, 95%CI: (10.69 to 51.05)] and extracorporeal membrane oxygenation [(OR) = 2.31, 95%CI: (1.25 to 4.26)]. Factors not associated with AKI after heart transplantation included Recipients' male sex (P = 0.55), donor sex (P = 0.11), hypertension (P = 0.13), smoking (P = 0.20), coronary artery disease (P = 0.90), pulmonary artery disease (P = 0.81), dilated cardiomyopathy (P = 0.79), ventilation duration (P = 0.24), ischemic time (P = 0.06), use of intra-aortic balloon pump (P = 0.14), LVAD transplantation (P = 0.83), and Inotropes use (P = 0.78). CONCLUSION: Age, BMI, diabetes, CKD, COPD, previous thoracic surgery, prolonged CPB time, extended mechanical ventilation, and ECMO use are significant predictors of AKI following heart transplantation, necessitating vigilant monitoring and individualized risk assessment. Conversely, factors such as LVAD implantation and inotrope use showed no significant association, highlighting the need for further investigation into their roles. Future prospective studies are essential to validate these findings, elucidate underlying mechanisms, and develop targeted interventions to mitigate AKI risk and improve patient outcomes. CI - (c)The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. FAU - Khawar, Muneeb AU - Khawar M AD - Department of Medicine, King Edward Medical University, Lahore 54000, Punjab, Pakistan. FAU - Sehar, Ayesha AU - Sehar A AD - Department of Medicine, King Edward Medical University, Lahore 54000, Punjab, Pakistan. FAU - Shahzad, Manahil AU - Shahzad M AD - Department of Medicine, King Edward Medical University, Lahore 54000, Punjab, Pakistan. FAU - Farooq, Hasnain AU - Farooq H AD - Department of Medicine, King Edward Medical University, Lahore 54000, Punjab, Pakistan. FAU - Rehman, Obaid Ur AU - Rehman OU AD - Department of Medicine, Services Institute of Medical Sciences, Lahore 54000, Punjab, Pakistan. FAU - Alvi, Zainab AU - Alvi Z AD - Department of Medicine, King Edward Medical University, Lahore 54000, Punjab, Pakistan. FAU - Ali, Sheraz AU - Ali S AD - Department of Medicine, King Edward Medical University, Lahore 54000, Punjab, Pakistan. FAU - Hadeed Khawar, Mirza Muhammad AU - Hadeed Khawar MM AD - Department of Medicine, Services Institute of Medical Sciences, Lahore 54000, Punjab, Pakistan. FAU - Saifullah, Muneeb AU - Saifullah M AD - Department of Medicine, King Edward Medical University, Lahore 54000, Punjab, Pakistan. FAU - Khail, Hamza Aka AU - Khail HA AD - Department of Medicine, Kateb University Faculty of Medicine, Kabul 1006, Kabul, Afghanistan. hamzaakakhail14@gmail.com. FAU - Qadeer, Abdul AU - Qadeer A AD - Department of Medicine, Mayo Clinic Hospital, Phoenix, AZ 85054, United States. FAU - Villanueva, Mark N AU - Villanueva MN AD - Department of Nephrology, Mayo Clinic Hospital, Phoenix, AZ 85054, United States. FAU - Mour, Girish K AU - Mour GK AD - Department of Nephrology, Mayo Clinic Hospital, Phoenix, AZ 85054, United States. LA - eng PT - Journal Article PL - United States TA - World J Nephrol JT - World journal of nephrology JID - 101610229 PMC - PMC12754407 OTO - NOTNLM OT - Acute kidney injury OT - Age OT - Body mass index OT - Cardiac transplantation OT - Chronic kidney disease OT - Diabetes OT - Kidney failure OT - Risk factors COIS- Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose. EDAT- 2026/01/02 06:29 MHDA- 2026/01/02 06:30 PMCR- 2025/12/25 CRDT- 2026/01/02 04:39 PHST- 2025/06/16 00:00 [received] PHST- 2025/07/04 00:00 [revised] PHST- 2025/09/24 00:00 [accepted] PHST- 2026/01/02 06:30 [medline] PHST- 2026/01/02 06:29 [pubmed] PHST- 2026/01/02 04:39 [entrez] PHST- 2025/12/25 00:00 [pmc-release] AID - 10.5527/wjn.v14.i4.110791 [doi] PST - ppublish SO - World J Nephrol. 2025 Dec 25;14(4):110791. doi: 10.5527/wjn.v14.i4.110791. PMID- 41478747 OWN - NLM STAT- MEDLINE DCOM- 20260212 LR - 20260212 IS - 1590-3729 (Electronic) IS - 0939-4753 (Linking) VI - 36 IP - 3 DP - 2026 Mar TI - Dietary tryptophan intake density and the risk of cardiovascular diseases: insights from a prospective cohort study. PG - 104468 LID - S0939-4753(25)00623-4 [pii] LID - 10.1016/j.numecd.2025.104468 [doi] AB - BACKGROUND AND AIM: Tryptophan's metabolic products, serotonin and melatonin, exhibit antioxidant activity and neuroprotective properties, thereby preventing mortality from cardiovascular diseases (CVD). We aim to examine the relationship between dietary tryptophan intake density and the risk of CVD. METHODS AND RESULTS: A prospective cohort study was conducted in northern Vietnam from 2008 to 2019, which comprises 42,146 participants aged 10 and older. Dietary tryptophan intake density per 1000 kcal was assessed using a validated semi-quantitative food frequency questionnaire. CVD deaths were 348 cases. The mean age was 38.5 years; 48 % were male and 52 % were female. The median follow-up duration was 11.01 years. Hazard ratio and 95 % confidence interval HR (95 % CI) were calculated for the association between dietary tryptophan intake density and mortality risks from CVD. The inverse association between dietary tryptophan intake density, top to bottom quintile, and CVD was seen for the entire study population, HR (95 % CI): 0.59 (0.42, 0.83), and after excluding deaths in the first three years, HR (95 % CI): 0.59 (0.41, 0.86). The results remained after additional adjustment for pack-years of smoking. A similar protective pattern was observed in subgroups with BMI <23 kg/m(2), smokers, drinkers, and men. The beneficial effect was observed in both young adults and those 65 years or older. CONCLUSIONS: A beneficial effect of dietary tryptophan intake density against the risk of CVD was observed. The findings warrant further research to understand the mechanism and its application in preventing CVD. CI - Copyright (c) 2025 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved. FAU - Nguyen, Hieu Lan AU - Nguyen HL AD - Dept. of Cardiology, Hanoi Medical University Hospital, Hanoi Medical University, Hanoi City, Viet Nam. Electronic address: Nguyenlanhieu.muh@gmail.com. FAU - Le, Linh Thuy AU - Le LT AD - Laboratory of Embryology and Genetics of Human Malformation, Imagine Institute, INSERM UMR, Paris City, France. Electronic address: lelinh2611@gmail.com. FAU - Nguyen, Thinh Gia AU - Nguyen TG AD - School of Medicine, International University of Health and Welfare, Narita City, Japan. Electronic address: giathinh7576@gmail.com. FAU - Nguyen, Quynh Thu AU - Nguyen QT AD - Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555, Japan. Electronic address: quynh@med.uoeh-u.ac.jp. FAU - Nguyen, Hieu Van AU - Nguyen HV AD - Dept. of Cardiology, Hanoi Medical University Hospital, Hanoi Medical University, Hanoi City, Viet Nam. Electronic address: vanhieuyhn@gmail.com. FAU - Le, Ngoan Tran AU - Le NT AD - Department of Clinical Research, Vinmec Healthcare System, Hanoi City, 113-900, Viet Nam; Institute of Research and Development, Duy Tan University, Da Nang City, Viet Nam. Electronic address: letranngoan@duytan.edu.vn. LA - eng PT - Journal Article DEP - 20251120 PL - Netherlands TA - Nutr Metab Cardiovasc Dis JT - Nutrition, metabolism, and cardiovascular diseases : NMCD JID - 9111474 RN - 8DUH1N11BX (Tryptophan) SB - IM MH - Humans MH - Male MH - *Tryptophan/administration & dosage/adverse effects MH - Female MH - Prospective Studies MH - *Cardiovascular Diseases/prevention & control/mortality/diagnosis/epidemiology MH - Adult MH - Middle Aged MH - Protective Factors MH - Risk Assessment MH - Heart Disease Risk Factors MH - Time Factors MH - Young Adult MH - Vietnam/epidemiology MH - Adolescent MH - Child MH - *Diet, Healthy MH - Nutritive Value MH - Aged MH - Prognosis MH - Recommended Dietary Allowances OTO - NOTNLM OT - CVD OT - Dietary tryptophan intake density OT - Epidemiology OT - Prospective cohort study COIS- Conflict of interest The authors declare no competing interests. EDAT- 2026/01/02 00:33 MHDA- 2026/02/13 01:26 CRDT- 2026/01/01 21:57 PHST- 2025/07/22 00:00 [received] PHST- 2025/10/29 00:00 [revised] PHST- 2025/11/07 00:00 [accepted] PHST- 2026/02/13 01:26 [medline] PHST- 2026/01/02 00:33 [pubmed] PHST- 2026/01/01 21:57 [entrez] AID - S0939-4753(25)00623-4 [pii] AID - 10.1016/j.numecd.2025.104468 [doi] PST - ppublish SO - Nutr Metab Cardiovasc Dis. 2026 Mar;36(3):104468. doi: 10.1016/j.numecd.2025.104468. Epub 2025 Nov 20. PMID- 41474788 OWN - NLM STAT- MEDLINE DCOM- 20251231 LR - 20260513 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 12 DP - 2025 TI - Exploring gut microbiome and nutritional status among children with Autism Spectrum Disorder (MY-ASD Microbiome): A study protocol. PG - e0338801 LID - 10.1371/journal.pone.0338801 [doi] LID - e0338801 AB - BACKGROUND: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterised by persistent deficits in social communication and the presence of restricted, repetitive behaviours or interests. Previous literature has identified a link between the gut and ASD; however, the underlying mechanisms remain unclear. Gut microbiota dysbiosis has been extensively reported in cohort studies of ASD, and specific microbial metabolites or by-products may serve as potential biomarkers for ASD. Additionally, children with ASD often exhibit food refusal, have a limited food repertoire and display a tendency to consume the same foods frequently; thus, these behaviours increase their risk of malnutrition (over-nutrition or under-nutrition) compared to typically developing (TD) healthy children. This study primarily aims to identify oral and gut microbiota among children with ASD and TD healthy children. The secondary aim is to determine the associations between oral and gut microbiota with nutritional status among children with ASD. The findings will enhance understanding of the aetiology of ASD and inform early intervention strategies to mitigate disease severity and early identification of malnutrition in genetically at-risk children. METHODS AND ANALYSIS: This observational, age-matched, case-control study is conducted in Malaysia among 40 male children with ASD and age-matched with 40 TD healthy controls aged 4-10 years. The dependent variables include the microbiota profile, identified through metagenomic sequencing analysis of saliva and faecal samples, and autism severity, assessed through validated questionnaires. Independent variables include nutritional status, determined through Subjective Global Nutrition Assessment (SGNA), anthropometry and dietary measurements, gastrointestinal symptoms, eating behaviour, behavioural profile, and sleep quality. Data collection is expected to be completed by June 2026. The study nature may limit causality establishment. Analyses will use chi-square/ANOVA for group comparisons, SparCC for microbiota correlations, and mixed-effects logistic regression to model associations. CONCLUSION: This study advances understanding of ASD-related microbiota, guiding personalised nutrition and precision healthcare in Malaysia. CI - Copyright: (c) 2025 Wong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Wong, Kai Xuan AU - Wong KX AUID- ORCID: 0009-0004-5349-9180 AD - Centre of Postgraduate Studies by Research, IMU University, Kuala Lumpur, Malaysia. AD - Institute for Research, Development and Innovation (IRDI), IMU University, Kuala Lumpur, Malaysia. FAU - Chen, Seong Ting AU - Chen ST AD - Division of Nutrition and Dietetics, IMU University, Kuala Lumpur, Malaysia. FAU - Ong, Jun Jean AU - Ong JJ AD - Paediatric Department, School of Medicine, IMU Clinical Campus Seremban, Negeri Sembilan, Malaysia. FAU - Gan, Wan Ying AU - Gan WY AUID- ORCID: 0000-0002-9016-3414 AD - Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia. FAU - Abdul Murad, Nor Azian AU - Abdul Murad NA AD - UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia (UKM), Cheras, Kuala Lumpur, Malaysia. FAU - Chong, Chun Wie AU - Chong CW AD - (FUTURE) Monash Microbiome Research Centre, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia. FAU - Ramzi, Nurul Hanis AU - Ramzi NH AUID- ORCID: 0000-0002-7622-7581 AD - Institute for Research, Development and Innovation (IRDI), IMU University, Kuala Lumpur, Malaysia. AD - Centre for Cancer and Stem Cell Research, Institute for Research, Development and Innovation, IMU University, Kuala Lumpur, Malaysia. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20251231 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Male MH - *Autism Spectrum Disorder/microbiology MH - Case-Control Studies MH - Feces/microbiology MH - *Gastrointestinal Microbiome MH - Malaysia MH - *Nutritional Status MH - Saliva/microbiology MH - Observational Studies as Topic PMC - PMC12755732 COIS- The authors have declared that no competing interests exist. EDAT- 2025/12/31 19:16 MHDA- 2025/12/31 19:17 PMCR- 2025/12/31 CRDT- 2025/12/31 13:53 PHST- 2025/02/24 00:00 [received] PHST- 2025/11/25 00:00 [accepted] PHST- 2025/12/31 19:17 [medline] PHST- 2025/12/31 19:16 [pubmed] PHST- 2025/12/31 13:53 [entrez] PHST- 2025/12/31 00:00 [pmc-release] AID - PONE-D-25-08831 [pii] AID - 10.1371/journal.pone.0338801 [doi] PST - epublish SO - PLoS One. 2025 Dec 31;20(12):e0338801. doi: 10.1371/journal.pone.0338801. eCollection 2025. PMID- 41473018 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251231 LR - 20260102 IS - 2666-6677 (Electronic) IS - 2666-6677 (Linking) VI - 24 DP - 2025 Dec TI - Wearable device-measured physical activity and risk of MAFLD in adolescents. PG - 101345 LID - 10.1016/j.ajpc.2025.101345 [doi] LID - 101345 AB - BACKGROUND: While physical activity is known to affect the risk of MAFLD in adults, evidence in adolescents is limited and often based on self-reported questionnaires. We therefore used wearable device-based measurements to investigate the association between physical activity and MAFLD in adolescents. METHODS: Data were obtained from the National Health and Nutrition Examination Survey (NHANES) database for adolescents aged 12-19 years during the 2003-2006 and 2011-2014 cycle. Physical activity was measured using wearable accelerometers, averaged across all valid wearing days. Weighted multivariate logistic regressions were applied to assess associations between physical activity (overall, daytime, and nighttime) and MAFLD. RESULT: Among 5705 adolescents, higher physical activity levels were strongly associated with lower odds of MAFLD in the 2003-2006 cycle, with a clear dose-response trend across quartiles (P for trend < 0.001). Participants in the highest physical activity (Q4) had 60 % lower odds overall, 58 % lower odds for daytime, and 43 % lower odds for nighttime activity, compared with those with lowest physical activity (Q1). The association between higher physical activity and lower MAFLD risk was generally observed across sex, age, and income subgroups. In contrast, no significant association between physical activity and MAFLD risk was observed in the 2011-2014 cycle. CONCLUSION: Our results suggest that higher levels of physical activity, especially during the daytime, may protect against MAFLD in adolescents. Our findings offer partial evidence for the role of circadian activity patterns in MAFLD risk and underscore the need for future studies to validate these associations. CI - (c) 2025 The Authors. Published by Elsevier B.V. FAU - Wang, Ruli AU - Wang R AD - Department of Paediatrics, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Wuxi, China. FAU - You, Congwei AU - You C AD - Department of Paediatrics, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China. FAU - Dong, Zijuan AU - Dong Z AD - Department of Paediatrics, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Wuxi, China. FAU - Zheng, Qingqing AU - Zheng Q AD - Department of Paediatrics, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China. FAU - Zheng, Xiaowei AU - Zheng X AD - Public Health Research Center and Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, China. FAU - Zhou, Liangbin AU - Zhou L AD - Department of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Hong Kong, China. FAU - Wang, Xiaolei AU - Wang X AD - Department of Paediatrics, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China. FAU - Zhang, Le AU - Zhang L AD - Department of Paediatrics, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Wuxi, China. FAU - Zhang, Haoyang AU - Zhang H AD - Department of Experimental Medical Science, Lund University, Lund, Sweden. LA - eng PT - Journal Article DEP - 20251103 PL - Netherlands TA - Am J Prev Cardiol JT - American journal of preventive cardiology JID - 101769122 PMC - PMC12746288 OTO - NOTNLM OT - Adolescent OT - MAFLD OT - Physical activity OT - Wearable devices COIS- We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome EDAT- 2025/12/31 07:37 MHDA- 2025/12/31 07:38 PMCR- 2025/11/03 CRDT- 2025/12/31 04:48 PHST- 2025/08/19 00:00 [received] PHST- 2025/10/15 00:00 [revised] PHST- 2025/11/02 00:00 [accepted] PHST- 2025/12/31 07:38 [medline] PHST- 2025/12/31 07:37 [pubmed] PHST- 2025/12/31 04:48 [entrez] PHST- 2025/11/03 00:00 [pmc-release] AID - S2666-6677(25)00420-9 [pii] AID - 101345 [pii] AID - 10.1016/j.ajpc.2025.101345 [doi] PST - epublish SO - Am J Prev Cardiol. 2025 Nov 3;24:101345. doi: 10.1016/j.ajpc.2025.101345. eCollection 2025 Dec. PMID- 41470869 OWN - NLM STAT- MEDLINE DCOM- 20251231 LR - 20260103 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 24 DP - 2025 Dec 15 TI - Virtual Reality Trier Social Stress and Virtual Supermarket Exposure: Electrocardiogram Correlates of Food Craving and Eating Traits in Adolescents. LID - 10.3390/nu17243924 [doi] LID - 3924 AB - BACKGROUND/OBJECTIVES: Acute stress is known to influence food-related motivation and decision-making, often promoting a preference for energy-dense, palatable foods. However, traditional laboratory paradigms have limited ecological validity. This study examined the relationship between stress-induced physiological changes, eating behavior traits, and food cravings using a virtual reality (VR) adaptation of the Trier Social Stress Test (VR-TSST) followed by a VR supermarket task in adolescents. METHODS: Thirty-eight adolescents (mean age 15.8 +/- 0.6 years) participated in the study. Physiological parameters (HR, QT, PQ intervals) were recorded pre- and post-stress using a portable ECG device (WIWE). Perceived stress and eating behavior traits were evaluated with the Perceived Stress Scale (PSS) and the Three-Factor Eating Questionnaire (TFEQ-R21C), respectively. Immediately after the VR-TSST, participants performed a VR supermarket task in which they rated cravings for sweet, fatty, and healthy foods using visual analog scales (VAS). Paired-samples t-tests examined pre-post changes in physiological parameters, partial correlations explored associations between ECG responses and eating traits, and a 2 x 3 mixed-model Repeated Measures ANOVA assessed the effects of food type (sweet, fatty, healthy) and uncontrolled eating (UE) group (low vs. high) on post-stress cravings. RESULTS: Acute stress induced significant increases in HR and QTc intervals (p < 0.01), confirming a robust physiological stress response. The ANOVA revealed a strong main effect of food type (F(1.93, 435.41) = 168.98, p < 0.001, eta(2)p = 0.43), indicating that stress-induced cravings differed across food categories, with sweet foods rated highest. A significant food type x UE group interaction (F(1.93, 435.41) = 16.49, p < 0.001, eta(2)p = 0.07) showed that adolescents with high UE exhibited greater cravings for sweet and fatty foods than those with low UE. Overall, craving levels did not differ significantly between groups. CONCLUSIONS: The findings demonstrate that acute stress selectively enhances cravings for high-reward foods, and that this effect is modulated by baseline uncontrolled eating tendencies. The combined use of VR-based stress induction and VR supermarket simulation offers an innovative, ecologically valid framework for studying stress-related eating behavior in adolescents, with potential implications for personalized nutrition and the prevention of stress-induced overeating. FAU - Onita, Cristiana Amalia AU - Onita CA AUID- ORCID: 0009-0006-7088-3971 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700588 Iasi, Romania. FAU - Matei, Daniela-Viorelia AU - Matei DV AUID- ORCID: 0000-0002-4609-7288 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700588 Iasi, Romania. FAU - Chelarasu, Elena AU - Chelarasu E AD - Computer Science Department, Faculty of Automatic Control and Computer Science, Gheorghe Asachi Technical University of Iasi, 700050 Iasi, Romania. FAU - Lupu, Robert Gabriel AU - Lupu RG AUID- ORCID: 0000-0002-2494-1070 AD - Computer Science Department, Faculty of Automatic Control and Computer Science, Gheorghe Asachi Technical University of Iasi, 700050 Iasi, Romania. FAU - Petrescu-Miron, Diana AU - Petrescu-Miron D AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700588 Iasi, Romania. FAU - Visnevschi, Anatolie AU - Visnevschi A AUID- ORCID: 0000-0001-9664-7527 AD - Department of Laboratory Medicine, "Nicolae Testemitanu" State University of Medicine and Pharmacy, 165, Bd. Stefan cel Mare si Sfant, MD-2004 Chisinau, Moldova. AD - Research Center of Adipose Tissue Biology, "Nicolae Testemitanu" State University of Medicine and Pharmacy, 165, Bd. Stefan cel Mare si Sfant, MD-2004 Chisinau, Moldova. FAU - Vudu, Stela AU - Vudu S AUID- ORCID: 0000-0002-0377-9131 AD - Research Center of Adipose Tissue Biology, "Nicolae Testemitanu" State University of Medicine and Pharmacy, 165, Bd. Stefan cel Mare si Sfant, MD-2004 Chisinau, Moldova. AD - Department of Endocrinology, "Nicolae Testemitanu" State University of Medicine and Pharmacy, 165, Bd. Stefan cel Mare si Sfant, MD-2004 Chisinau, Moldova. FAU - Corciova, Calin AU - Corciova C AUID- ORCID: 0000-0002-0641-8323 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700588 Iasi, Romania. FAU - Fuior, Robert AU - Fuior R AUID- ORCID: 0000-0001-7067-7701 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700588 Iasi, Romania. FAU - Tupita, Nicoleta AU - Tupita N AD - Romanian Rugby Federation, 011468 Bucharest, Romania. FAU - Bouchard, Stephane AU - Bouchard S AUID- ORCID: 0000-0002-5995-340X AD - Departement de Psychologie et de Psychoeducation, Universite du Quebec en Outaouais, Gatineau, QC J8X 3X7, Canada. FAU - Mocanu, Veronica AU - Mocanu V AUID- ORCID: 0000-0002-9330-1691 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700588 Iasi, Romania. LA - eng GR - 1HARD/4.1/93/European Union/ PT - Journal Article DEP - 20251215 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - *Craving/physiology MH - Female MH - *Stress, Psychological/physiopathology/psychology MH - Male MH - *Electrocardiography MH - *Virtual Reality MH - *Feeding Behavior/psychology/physiology MH - *Food Preferences/psychology MH - Heart Rate MH - Surveys and Questionnaires MH - *Eating/psychology/physiology PMC - PMC12736307 OTO - NOTNLM OT - Trier Social Stress Test OT - adolescents OT - eating behavior OT - electrocardiogram (ECG) parameters OT - three-factor eating questionnaire (TFEQ) OT - virtual reality OT - virtual supermarket COIS- S.B. is president and owner of Clinique et Development In Virtuo, a spin-off company from his university that distributes virtual environments. The terms and arrangements for this spin-off have been reviewed and approved by the Universite du Quebec en Outaouais in accordance with its Conflict of Interest policies. He also receives honoraria from conferences, workshops, and books. The other authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/31 07:37 MHDA- 2025/12/31 07:38 PMCR- 2025/12/15 CRDT- 2025/12/31 01:05 PHST- 2025/09/30 00:00 [received] PHST- 2025/12/08 00:00 [revised] PHST- 2025/12/11 00:00 [accepted] PHST- 2025/12/31 07:38 [medline] PHST- 2025/12/31 07:37 [pubmed] PHST- 2025/12/31 01:05 [entrez] PHST- 2025/12/15 00:00 [pmc-release] AID - nu17243924 [pii] AID - nutrients-17-03924 [pii] AID - 10.3390/nu17243924 [doi] PST - epublish SO - Nutrients. 2025 Dec 15;17(24):3924. doi: 10.3390/nu17243924. PMID- 41470823 OWN - NLM STAT- MEDLINE DCOM- 20251231 LR - 20260103 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 24 DP - 2025 Dec 12 TI - Perspectives of Non-Medical Professionals Working in a Mental Health Service on Eating Disorders: Awareness, Knowledge, and Stigmatisation. LID - 10.3390/nu17243878 [doi] LID - 3878 AB - Background: Eating disorders (EDs) are serious mental health conditions often beginning in adolescence and are associated with significant morbidity and mortality. Although previous research has focused on medical staff, little is known about how EDs are recognised and managed by non-medical mental health professionals within community-based systems. This study examined their awareness, knowledge, and stigmatising beliefs toward EDs in Turkiye, highlighting implications for training and policy development. Methods: A study-specific questionnaire adapted from a validated tool previously used with general practitioners was administered to 42 non-medical professionals (95.2% female; mean age = 33.2 +/- 5.6 years) working in community mental health services in Ankara, Turkiye. Participants were randomly assigned to one of six clinical vignettes depicting a young person with anorexia nervosa (AN), bulimia nervosa, binge eating disorder, avoidant/restrictive food intake disorder (ARFID), depression, or type-1 diabetes. The questionnaire assessed illness perception, causal attributions, emotional reactions, professional knowledge, and stigmatising beliefs. Results: Only 28.6% (n = 12) correctly identified the disorder in their assigned vignette. BED had the highest diagnostic accuracy (50%), while AN and ARFID were most frequently misidentified. Participants commonly believed that EDs mainly affected females, had a short duration, and were less responsive to treatment. Stigmatising beliefs-such as personal blame-were also noted. Conclusions: Findings revealed limited awareness and knowledge of EDs-particularly AN and ARFID-among non-medical mental health professionals. Misconceptions that EDs are self-inflicted may delay recognition and referral. The results underscore the need for targeted education, anti-stigma interventions, and integration of ED content into professional training to improve early detection and community-based support. FAU - Ogutlu, Hakan AU - Ogutlu H AUID- ORCID: 0000-0002-1325-446X AD - Department of Child & Adolescent Psychiatry, Cognitive Behavioral Psychotherapies Association, Ankara 06680, Turkey. FAU - Tekeoglu, Ugur AU - Tekeoglu U AUID- ORCID: 0000-0002-8432-7566 AD - Department of Child & Adolescent Psychiatry, Faculty of Medicine, Recep Tayyip Erdogan University, Rize 53100, Turkey. FAU - McNicholas, Fiona AU - McNicholas F AUID- ORCID: 0000-0001-9428-6908 AD - Department of Child & Adolescent Psychiatry, School of Medicine and Medical Science, University College Dublin, D04 V1W8 Dublin, Ireland. LA - eng GR - Grant number to be assigned./Recep Tayyip Erdogan University/ PT - Journal Article DEP - 20251212 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Adult MH - *Feeding and Eating Disorders/psychology/diagnosis/therapy MH - *Health Knowledge, Attitudes, Practice MH - Male MH - Surveys and Questionnaires MH - *Social Stigma MH - *Health Personnel/psychology MH - *Mental Health Services MH - Attitude of Health Personnel MH - Middle Aged MH - Young Adult MH - Awareness MH - Stereotyping PMC - PMC12736076 OTO - NOTNLM OT - Turkiye OT - awareness OT - eating disorders OT - non-medical professionals OT - stigma OT - training COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2025/12/31 07:37 MHDA- 2025/12/31 07:38 PMCR- 2025/12/12 CRDT- 2025/12/31 01:04 PHST- 2025/09/02 00:00 [received] PHST- 2025/10/05 00:00 [revised] PHST- 2025/10/23 00:00 [accepted] PHST- 2025/12/31 07:38 [medline] PHST- 2025/12/31 07:37 [pubmed] PHST- 2025/12/31 01:04 [entrez] PHST- 2025/12/12 00:00 [pmc-release] AID - nu17243878 [pii] AID - nutrients-17-03878 [pii] AID - 10.3390/nu17243878 [doi] PST - epublish SO - Nutrients. 2025 Dec 12;17(24):3878. doi: 10.3390/nu17243878. PMID- 41470795 OWN - NLM STAT- MEDLINE DCOM- 20251231 LR - 20260103 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 24 DP - 2025 Dec 10 TI - Dietary Inflammatory Potential and Sociodemographic Correlates Among Adults in Saudi Arabia: A Cross-Sectional Study. LID - 10.3390/nu17243851 [doi] LID - 3851 AB - Background: Dietary patterns influence systemic inflammation, which is involved in the pathogenesis of non-communicable diseases. The dietary inflammatory index (DII) quantifies the inflammatory potential of the diet and varies across populations due to cultural and regional eating habits. Limited data exist on the inflammatory potential of diets in Saudi Arabia. This study aimed to assess the inflammatory potential of the diet and its association with sociodemographic and lifestyle factors among adults in Saudi Arabia. Methods: A cross-sectional study included 256 adults aged 18-50 years residing in Saudi Arabia. Participants were recruited using convenience sampling via social media platforms. Data were collected between November 2024 and August 2025 using a validated Saudi food frequency questionnaire and sociodemographic survey. Energy-adjusted DII (E-DII) scores were calculated using 42 food parameters. Non-parametric tests (Mann-Whitney U and Kruskal-Wallis) were applied to examine associations between E-DII and sociodemographic variables. Results: Significant differences in E-DII were observed by sex (p < 0.001). Males had higher E-DII scores than females, suggesting more pro-inflammatory diets. Participants with postgraduate education tended to have lower E-DII than participants with only a high school degree, reflecting more anti-inflammatory dietary patterns. However, this trend was not statistically significant (p = 0.06). The mean E-DII was 4.8 +/- 1.3, indicating a predominantly pro-inflammatory dietary pattern. No significant differences were found across age, education, income, BMI, marital status, employment, or smoking status. Conclusions: Sex was a key determinant of dietary inflammatory potential. Adults demonstrated overall pro-inflammatory dietary patterns in Saudi Arabia. Public health interventions should target higher risk groups, such as males with a higher risk of non-communicable diseases, to promote anti-inflammatory dietary habits and reduce chronic disease risk in this population. FAU - Asiri, Raneem AU - Asiri R AD - Department of Clinical Nutrition, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia. FAU - Alashmali, Shoug AU - Alashmali S AUID- ORCID: 0000-0001-5675-2832 AD - Department of Clinical Nutrition, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia. LA - eng PT - Journal Article DEP - 20251210 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adult MH - Saudi Arabia/epidemiology MH - Male MH - Female MH - Cross-Sectional Studies MH - Middle Aged MH - Young Adult MH - *Inflammation/epidemiology/etiology MH - *Diet/adverse effects/statistics & numerical data MH - Adolescent MH - Sociodemographic Factors MH - *Feeding Behavior MH - Sex Factors MH - Socioeconomic Factors MH - Life Style PMC - PMC12736128 OTO - NOTNLM OT - Saudi Arabia OT - adults OT - diet OT - inflammation OT - sociodemographic COIS- The authors declare no conflicts of interest. EDAT- 2025/12/31 07:37 MHDA- 2025/12/31 07:38 PMCR- 2025/12/10 CRDT- 2025/12/31 01:04 PHST- 2025/10/31 00:00 [received] PHST- 2025/12/02 00:00 [revised] PHST- 2025/12/06 00:00 [accepted] PHST- 2025/12/31 07:38 [medline] PHST- 2025/12/31 07:37 [pubmed] PHST- 2025/12/31 01:04 [entrez] PHST- 2025/12/10 00:00 [pmc-release] AID - nu17243851 [pii] AID - nutrients-17-03851 [pii] AID - 10.3390/nu17243851 [doi] PST - epublish SO - Nutrients. 2025 Dec 10;17(24):3851. doi: 10.3390/nu17243851. PMID- 41470760 OWN - NLM STAT- MEDLINE DCOM- 20251231 LR - 20260103 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 24 DP - 2025 Dec 5 TI - Orthorexia Profiles in Athletes: A Multidimensional Analysis Using the Eating Habits Questionnaire (EHQ) and the Teruel Orthorexia Scale (TOS). LID - 10.3390/nu17243814 [doi] LID - 3814 AB - Background: Orthorexia nervosa (OrNe) and healthy orthorexia (HeOr) are two distinct but related dimensions of interest in eating behavior research. Evidence regarding their associations with sociodemographic, dietary, and sport-related variables in physically active young adults remains limited. Methods: A cross-sectional study was conducted in 190 physically active young adults (53.2% women; mean age = 23.16 +/- 5.13 years). Participants practiced a variety of sports including fitness (25.3%), soccer (13.7%), handball (10.5%), athletics, martial arts, cycling, and other individual or team sports. Although all participants belonged to organized sports teams or structured training groups, 38.9% were not actively competing at the time of data collection. Participants completed validated instruments assessing OrNe, HeOr, and eating-related cognitions, alongside questionnaires on sociodemographic data, dietary habits, sport discipline, training frequency, and supplement use. Hierarchical and K-means clustering were applied using the standardized scores of HeOr, OrNe, and the EHQ total score. Group differences were assessed using t-tests and ANOVA with effect sizes (eta(2)p) reported. Results: Age correlated positively with OrNe, HeOr, and eating-related cognitions, indicating greater consolidation of rigid eating patterns in young adulthood. BMI was associated with OrNe only among men. Vegetarian participants showed higher nutritional knowledge but lower overall orthorexia scores. Supplement users in fitness-related sports reported higher OrNe, whereas participants in collective sports reported lower scores. Three distinct orthorexia profiles were identified, characterized by lower, slightly above-average, and higher scores on orthorexia-related variables. Participants in the higher-scoring profile showed significantly higher EHQ total, OrNe, and HeOr scores compared with the other groups (eta(2)p range = 0.11-0.19). Correlations among orthorexia dimensions were positive and moderate to large. Differences between clusters in sport modality, training frequency, and supplement use underscored the influence of the sporting context. Conclusions: Orthorexia in young physically active adults reflects heterogeneous patterns shaped by the interplay of individual (age, sex, BMI), dietary, and sport-related factors. The identification of differentiated profiles reinforces the multidimensional nature of orthorexia and underscores the relevance of considering specific sport environments when interpreting orthorexic tendencies. Longitudinal research is warranted to examine the stability or variability of these patterns over time and to enable the use of more robust multivariate approaches that further clarify the characterization of orthorexia. FAU - Manzanares-Cabrera, Maria AU - Manzanares-Cabrera M AD - Hospital Quiron Health Ciudad Real, 13002 Ciudad Real, Spain. FAU - Onieva-Zafra, Maria Dolores AU - Onieva-Zafra MD AUID- ORCID: 0000-0002-1052-2182 AD - Department of Nursing, Physiotherapy and Occupational Therapy, Ciudad Real Faculty of Nursing, University of Castilla-La Mancha, 13071 Ciudad Real, Spain. AD - Instituto de Investigacion Sanitaria de Castilla-La Mancha (IDISCAM), Castilla-La Mancha, 45004 Toledo, Spain. FAU - Bermejo-Cantarero, Alberto AU - Bermejo-Cantarero A AUID- ORCID: 0000-0001-6463-5556 AD - Department of Nursing, Physiotherapy and Occupational Therapy, Ciudad Real Faculty of Nursing, University of Castilla-La Mancha, 13071 Ciudad Real, Spain. AD - Instituto de Investigacion Sanitaria de Castilla-La Mancha (IDISCAM), Castilla-La Mancha, 45004 Toledo, Spain. AD - Centro de Estudios Sociosanitarios (CESS), University of Castilla-La Mancha, 13071 Cuenca, Spain. FAU - Exposito-Gonzalez, Raul AU - Exposito-Gonzalez R AUID- ORCID: 0000-0003-1481-4251 AD - Department of Nursing, Physiotherapy and Occupational Therapy, Ciudad Real Faculty of Nursing, University of Castilla-La Mancha, 13071 Ciudad Real, Spain. AD - Instituto de Investigacion Sanitaria de Castilla-La Mancha (IDISCAM), Castilla-La Mancha, 45004 Toledo, Spain. FAU - Lerma-Garcia, Daniel AU - Lerma-Garcia D AUID- ORCID: 0009-0000-0460-0933 AD - Department of Nursing, University of Illes Balears, Ibiza, Baleares, 07800 Ibiza, Spain. FAU - Parra-Fernandez, Maria Laura AU - Parra-Fernandez ML AUID- ORCID: 0000-0001-9681-1737 AD - Department of Nursing, Physiotherapy and Occupational Therapy, Ciudad Real Faculty of Nursing, University of Castilla-La Mancha, 13071 Ciudad Real, Spain. AD - Instituto de Investigacion Sanitaria de Castilla-La Mancha (IDISCAM), Castilla-La Mancha, 45004 Toledo, Spain. LA - eng PT - Journal Article DEP - 20251205 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Female MH - *Feeding Behavior/psychology MH - Cross-Sectional Studies MH - Young Adult MH - *Athletes/psychology MH - *Feeding and Eating Disorders/psychology/diagnosis MH - Surveys and Questionnaires MH - Adult MH - Adolescent MH - Sports/psychology MH - Health Behavior PMC - PMC12735428 OTO - NOTNLM OT - cluster analysis OT - dietary patterns OT - healthy orthorexia OT - orthorexia nervosa OT - sports OT - supplements OT - young adults COIS- The authors declare no conflicts of interest. EDAT- 2025/12/31 07:37 MHDA- 2025/12/31 07:38 PMCR- 2025/12/05 CRDT- 2025/12/31 01:04 PHST- 2025/10/31 00:00 [received] PHST- 2025/12/02 00:00 [revised] PHST- 2025/12/03 00:00 [accepted] PHST- 2025/12/31 07:38 [medline] PHST- 2025/12/31 07:37 [pubmed] PHST- 2025/12/31 01:04 [entrez] PHST- 2025/12/05 00:00 [pmc-release] AID - nu17243814 [pii] AID - nutrients-17-03814 [pii] AID - 10.3390/nu17243814 [doi] PST - epublish SO - Nutrients. 2025 Dec 5;17(24):3814. doi: 10.3390/nu17243814. PMID- 41470756 OWN - NLM STAT- MEDLINE DCOM- 20251231 LR - 20260103 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 24 DP - 2025 Dec 5 TI - FFQ-NutriForHer: Reproducibility and Validity of a Semi-Quantitative Food Frequency Questionnaire for Young and Older Women. LID - 10.3390/nu17243811 [doi] LID - 3811 AB - Background: Despite the growing interest in the relationship of diet and women's health conditions, a limited number of Food Frequency Questionnaires (FFQs) have been specifically developed and/or validated for use among women, and those that exist have been primarily developed and validated in non-European countries. This study aimed to evaluate the reproducibility and validity of the FFQ-NutriForHer among young and older Polish women. Methods: The reproducibility and validity of the 138-item FFQ-NutriForHer were evaluated in 121 young (18-30 years) and 88 older women (70-90 years). Reproducibility was assessed using energy-adjusted Pearson and intraclass correlation coefficients (PCCs, ICCs) from two FFQ administrations. Validity was evaluated by comparing energy-adjusted and de-attenuated PCCs between FFQ-mean and 3-day dietary records. The Bland-Altman method estimated mean differences and limits of agreement. Results: The mean PCCs and ICCs for macronutrient reproducibility were 0.69 +/- 0.12 and 0.69 +/- 0.11 among young women and 0.67 +/- 0.06 and 0.65 +/- 0.11 among older women, respectively, indicating moderate correlation and reliability in both groups. For micronutrients, the mean PCCs were 0.72 +/- 0.05 among young women and 0.69 +/- 0.05 among older women, while ICCs were 0.71 +/- 0.05 and 0.69 +/- 0.09, respectively, indicating a good and moderate correlation and moderate reliability. Mean PCCs for macronutrient validity indicated good concordance with values of 0.51 +/- 0.25 among young women and 0.46 +/- 0.13 among older women. For micronutrients, the mean PCC for validity was 0.63 +/- 0.13 among young women and 0.44 +/- 0.14 among older women. Bland-Altman analysis indicated good overall agreement between methods in both groups. Conclusions: Given its high reproducibility and satisfactory validity in both age groups, the FFQ-NutriForHer is a reliable tool for assessing dietary intake and exploring its links to women's health across different ages. FAU - Szmidt, Maria Karolina AU - Szmidt MK AUID- ORCID: 0000-0001-6970-1671 AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), Nowoursynowska 166, 02-787 Warsaw, Poland. FAU - Sicinska, Ewa AU - Sicinska E AUID- ORCID: 0000-0001-7187-319X AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), Nowoursynowska 166, 02-787 Warsaw, Poland. FAU - Januszko, Olga AU - Januszko O AUID- ORCID: 0000-0002-4768-4812 AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), Nowoursynowska 166, 02-787 Warsaw, Poland. FAU - Kaluza, Joanna AU - Kaluza J AUID- ORCID: 0000-0001-9454-0929 AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), Nowoursynowska 166, 02-787 Warsaw, Poland. LA - eng GR - n/a/Science Development Fund of the Warsaw University of Life Sciences - SGGW/ GR - n/a/Polish Ministry of Science and Higher Education with funds from the Institute of Human Nutri-tion Sciences, Warsaw University of Life Sciences (WULS)/ PT - Journal Article PT - Validation Study DEP - 20251205 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Reproducibility of Results MH - Aged MH - Adult MH - Young Adult MH - Adolescent MH - Aged, 80 and over MH - Surveys and Questionnaires/standards MH - *Diet Surveys/methods MH - *Diet MH - Poland MH - *Nutrition Assessment MH - Diet Records PMC - PMC12735852 OTO - NOTNLM OT - FFQ OT - diet assessment OT - reproducibility OT - validity OT - women COIS- The authors declare no conflicts of interest. EDAT- 2025/12/31 07:37 MHDA- 2025/12/31 07:38 PMCR- 2025/12/05 CRDT- 2025/12/31 01:04 PHST- 2025/10/30 00:00 [received] PHST- 2025/11/28 00:00 [revised] PHST- 2025/12/02 00:00 [accepted] PHST- 2025/12/31 07:38 [medline] PHST- 2025/12/31 07:37 [pubmed] PHST- 2025/12/31 01:04 [entrez] PHST- 2025/12/05 00:00 [pmc-release] AID - nu17243811 [pii] AID - nutrients-17-03811 [pii] AID - 10.3390/nu17243811 [doi] PST - epublish SO - Nutrients. 2025 Dec 5;17(24):3811. doi: 10.3390/nu17243811. PMID- 41469736 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2025 Dec 30 TI - The dual links of health literacy in driving exercise adherence: the interactive effects of emotional management ability and life satisfaction. PG - 143 LID - 10.1186/s40359-025-03889-1 [doi] LID - 143 AB - OBJECTIVE: Based on the Health Action Process Approach theory, this study aims to explore how health literacy influences exercise adherence among Chinese university students. It focuses on examining the chain mediating effects of emotional management ability and life satisfaction. METHOD: This study used a stratified, cluster, and phased sampling approach to gather demographic information. Data were collected through the Wenjuanxing platform. The survey gathered information on health literacy, emotional management ability, life satisfaction, and exercise adherence among university students. A total of 11,272 valid questionnaires were collected. RESULTS: Health literacy directly predicted exercise adherence positively (beta = 0.618, P < 0.001). Emotional management Ability (effect size = 0.281, 95% CI = [0.254, 0.308]) and life satisfaction (effect size = 0.054, 95% CI = [0.044, 0.065]) both served as independent mediators. Life satisfaction also emerged as a significant, albeit relatively small, independent mediator. The chain mediation path of health literacy --> emotional management ability --> life satisfaction --> exercise adherence was significant (effect size = 0.061, 95% CI = [0.051, 0.071]). CONCLUSION: Health literacy not only directly promotes exercise adherence among Chinese university students but also exerts an indirect effect through the chain mechanism of improved emotional management ability and enhanced life satisfaction. This finding validates the progressive cognitive-affective-behavioral pathway in the Health Action Process Approach theory. Future interventions should integrate health education, emotional management ability training, and life satisfaction enhancement strategies. This approach will systematically optimize the long-term maintenance of exercise behaviors. FAU - Zhang, Wen-Hao AU - Zhang WH AD - Institute of Sports Science, Nantong University, Nantong, 226019, China. FAU - Han, Shan-Shan AU - Han SS AD - Institute of Sports Science, Nantong University, Nantong, 226019, China. FAU - Lou, Hu AU - Lou H AD - Institute of Sports Science, Nantong University, Nantong, 226019, China. FAU - Qian, Yu-Yan AU - Qian YY AD - Journal Publishing Center, Nantong University, Nantong, 226019, China. FAU - Li, Bo AU - Li B AD - Institute of Sports Science, Nantong University, Nantong, 226019, China. wangqiulibo@163.com. FAU - Xu, Ling-Li AU - Xu LL AD - Institute of Sports Science, Nantong University, Nantong, 226019, China. 853314539@qq.com. LA - eng GR - No. 2025SJZD143/2025 Major Project of Philosophy and Social Science Research in Colleges and Universities: Research on the Formation Mechanism and Exercise Intervention of College Students' Mental Health Problems in the Era of Digital Intelligence/ PT - Journal Article DEP - 20251230 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Female MH - *Personal Satisfaction MH - *Exercise/psychology MH - Male MH - *Health Literacy MH - Young Adult MH - Adult MH - *Students/psychology/statistics & numerical data MH - China MH - *Emotional Regulation MH - Universities MH - Adolescent MH - Surveys and Questionnaires MH - Emotions PMC - PMC12866430 OTO - NOTNLM OT - Chinese university students OT - Emotional management ability OT - Exercise adherence OT - Health action process approach theory OT - Health literacy OT - Life satisfaction OT - Mediation analysis OT - Psychological mechanism COIS- Declarations. Ethics approval and consent to participate: Informed consent was obtained from all the subjects involved in the study. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/31 00:33 MHDA- 2026/06/27 00:51 PMCR- 2025/12/30 CRDT- 2025/12/30 23:36 PHST- 2025/09/10 00:00 [received] PHST- 2025/12/17 00:00 [accepted] PHST- 2026/06/27 00:51 [medline] PHST- 2025/12/31 00:33 [pubmed] PHST- 2025/12/30 23:36 [entrez] PHST- 2025/12/30 00:00 [pmc-release] AID - 10.1186/s40359-025-03889-1 [pii] AID - 3889 [pii] AID - 10.1186/s40359-025-03889-1 [doi] PST - epublish SO - BMC Psychol. 2025 Dec 30;14(1):143. doi: 10.1186/s40359-025-03889-1. PMID- 41469041 OWN - NLM STAT- MEDLINE DCOM- 20251230 LR - 20260307 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 12 DP - 2025 Dec 29 TI - Cost-effectiveness of pay-for-performance incentives for topical fluoride application among US children: a decision-analytic modelling study. PG - e111302 LID - 10.1136/bmjopen-2025-111302 [doi] LID - e111302 AB - OBJECTIVE: Pay-for-performance (P4P) programmes are increasingly implemented in healthcare to improve quality of care, but their application in dentistry remains limited. Evidence-based approaches are needed to guide incentive design in value-based dental care, particularly for preventive services, such as topical fluoride application in children. We sought to assess the potential cost-effectiveness of P4P incentives for increasing topical fluoride application among children and to illustrate how simulation modelling can identify conditions under which subgroup-specific incentive levels may be optimal. DESIGN, SETTING AND PARTICIPANTS: We developed and validated a decision-analytic microsimulation model using nationally representative data from the National Health and Nutrition Examination Survey (NHANES 2011-2016) to simulate a cohort of 100 000 US children aged 0-19 years over a 10-year period starting in 2024. The model incorporated heterogeneity in demographic and clinical characteristics to estimate changes in dental caries, quality-adjusted life years (QALYs) and healthcare costs under hypothetical P4P programmes that increased topical fluoride coverage by 2.5% to 50% relative to the baseline rate of 24.5%, with incentive amounts ranging from 2.5% to 50% of provider salary. Sensitivity analyses assessed robustness to variation in key parameters. MAIN OUTCOMES: Cumulative incidence of dental caries, QALYs, total healthcare costs and incremental cost-effectiveness ratios (ICERs). RESULTS: Across a broad range of incentive-coverage combinations, P4P incentives were generally cost-effective. For example, a 10% salary-based incentive linked to a 5% relative coverage increase reduced 186.3 cases of tooth decay and yielded 33.8 QALY gains per 10 000 children, resulting in an ICER of $8501 per QALY gained. The intervention was estimated to be cost-saving at coverage increases >/=27.5%. Subgroup analysis indicated larger absolute benefits among racial/ethnic minority children. CONCLUSION: P4P incentives to increase topical fluoride application in children could be cost-effective, and potentially cost-saving, under certain conditions. Cost-effectiveness modelling can help define incentive-coverage combinations that are likely to promote both efficiency and equity. Empirical studies are needed to validate provider responsiveness and establish achievable benchmarks for programme design. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Choi, Sung Eun AU - Choi SE AUID- ORCID: 0000-0002-4001-7638 AD - Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, Massachusetts, USA sung_choi@hsdm.harvard.edu. FAU - Nolte, Daniel AU - Nolte D AD - Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, Massachusetts, USA. FAU - Pandya, Ankur AU - Pandya A AD - Department of Health Policy and Management, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. LA - eng GR - R00 MD016895/MD/NIMHD NIH HHS/United States PT - Journal Article DEP - 20251229 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 RN - 0 (Fluorides, Topical) SB - IM MH - Humans MH - *Cost-Benefit Analysis MH - Child MH - *Fluorides, Topical/economics/administration & dosage/therapeutic use MH - Child, Preschool MH - United States/epidemiology MH - *Reimbursement, Incentive/economics MH - Adolescent MH - Male MH - Infant MH - *Dental Caries/prevention & control/economics/epidemiology MH - Female MH - Quality-Adjusted Life Years MH - Decision Support Techniques MH - Young Adult MH - Infant, Newborn MH - Nutrition Surveys MH - Fluoride Treatment PMC - PMC12750797 OTO - NOTNLM OT - Decision Making OT - Health economics OT - Health policy OT - Quality Improvement COIS- Competing interests: None declared. EDAT- 2025/12/31 00:33 MHDA- 2025/12/31 00:34 PMCR- 2025/12/29 CRDT- 2025/12/30 20:43 PHST- 2025/12/31 00:34 [medline] PHST- 2025/12/31 00:33 [pubmed] PHST- 2025/12/30 20:43 [entrez] PHST- 2025/12/29 00:00 [pmc-release] AID - bmjopen-2025-111302 [pii] AID - 10.1136/bmjopen-2025-111302 [doi] PST - epublish SO - BMJ Open. 2025 Dec 29;15(12):e111302. doi: 10.1136/bmjopen-2025-111302. PMID- 41468232 OWN - NLM STAT- MEDLINE DCOM- 20260318 LR - 20260318 IS - 1543-5474 (Electronic) IS - 1543-3080 (Linking) VI - 23 IP - 4 DP - 2026 Apr 1 TI - A Simple Tool to Assess Outdoor Gym Use. PG - 567-571 LID - 10.1123/jpah.2025-0434 [doi] AB - INTRODUCTION: Outdoor gyms present an opportunity to promote resistance training (RT) among the general population, however, there is a lack of reliable tools that can measure outdoor gym usage. We developed a modified version of the System of Observing Play and Recreation in Communities to assess Resistance Training using outdoor gyms (SOPARC-RT). METHODS: Paired assessors completed observations (N = 24) across 4 outdoor gyms. The interrater reliability was assessed using Bland-Altman plots, intraclass correlation coefficients, and weighted kappa coefficients based on distribution of the data. RESULTS: The SOPARC-RT tool demonstrated excellent interrater reliability for all users overall (intraclass correlation coefficients = .96; 95% confidence interval, .91-.99), as well as youth (children and adolescents), adults and seniors. CONCLUSIONS: SOPARC-RT is a reliable tool that can be utilized by researchers and local government agencies interested in measuring RT using outdoor gym equipment among the general population. FAU - Jansson, Anna K AU - Jansson AK AUID- ORCID: 0000-0001-9039-2033 AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. FAU - Duncan, Mitch J AU - Duncan MJ AUID- ORCID: 0000-0002-9166-6195 AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. AD - Global Sport and Movement Collaborative, University of Newcastle, Callaghan, NSW, Australia. AD - School of Medicine and Public Health, University of Newcastle, Callaghan,NSW, Australia. FAU - Beacroft, Sam AU - Beacroft S AUID- ORCID: 0009-0005-5821-9800 AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. AD - Global Sport and Movement Collaborative, University of Newcastle, Callaghan, NSW, Australia. FAU - Lubans, David R AU - Lubans DR AUID- ORCID: 0000-0002-0204-8257 AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. AD - Global Sport and Movement Collaborative, University of Newcastle, Callaghan, NSW, Australia. AD - Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland. FAU - Attia, John AU - Attia J AUID- ORCID: 0000-0001-9800-1308 AD - School of Medicine and Public Health, University of Newcastle, Callaghan,NSW, Australia. FAU - Bauman, Adrian AU - Bauman A AUID- ORCID: 0000-0002-0369-4621 AD - School of Public Health, The University of Sydney, Camperdown,NSW, Australia. FAU - Smith, Jordan J AU - Smith JJ AUID- ORCID: 0000-0003-4640-8645 AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. AD - Global Sport and Movement Collaborative, University of Newcastle, Callaghan, NSW, Australia. FAU - Plotnikoff, Ronald C AU - Plotnikoff RC AUID- ORCID: 0000-0002-3763-8273 AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. AD - Global Sport and Movement Collaborative, University of Newcastle, Callaghan, NSW, Australia. LA - eng PT - Journal Article DEP - 20251216 PL - United States TA - J Phys Act Health JT - Journal of physical activity & health JID - 101189457 SB - IM MH - Humans MH - Adult MH - Adolescent MH - Reproducibility of Results MH - Child MH - *Resistance Training MH - Male MH - Female MH - Aged MH - Young Adult MH - Middle Aged MH - *Fitness Centers/statistics & numerical data MH - Recreation MH - Observer Variation OTO - NOTNLM OT - measurement OT - resistance training EDAT- 2025/12/30 19:11 MHDA- 2026/03/18 12:53 CRDT- 2025/12/30 12:25 PHST- 2025/06/19 00:00 [received] PHST- 2025/09/23 00:00 [revised] PHST- 2025/10/26 00:00 [accepted] PHST- 2026/03/18 12:53 [medline] PHST- 2025/12/30 19:11 [pubmed] PHST- 2025/12/30 12:25 [entrez] AID - 10.1123/jpah.2025-0434 [doi] PST - epublish SO - J Phys Act Health. 2025 Dec 16;23(4):567-571. doi: 10.1123/jpah.2025-0434. Print 2026 Apr 1. PMID- 41468223 OWN - NLM STAT- MEDLINE DCOM- 20260127 LR - 20260127 IS - 1555-0273 (Electronic) IS - 1555-0265 (Linking) VI - 21 IP - 2 DP - 2026 Feb 1 TI - Feasibility and Accuracy of Body-Fat Assessment Using Standardized Skinfold-Thickness Assessment Versus Dual-Energy X-Ray Absorptiometry in Paralympic Athletes. PG - 241-251 LID - 10.1123/ijspp.2025-0284 [doi] AB - PURPOSE: To evaluate the feasibility and accuracy of body-fat assessment using standardized skinfold-thickness assessment versus dual-energy X-ray absorptiometry (DXA) in Paralympic athletes. METHOD: In this cross-sectional study, body composition was assessed in 49 male and female Paralympic athletes (Para cycling, Para skiing, Para swimming, wheelchair basketball, and wheelchair tennis) by a whole-body DXA scan and skinfold-thickness measurements conducted according to International Society for the Advancement of Kinanthropometry (ISAK) standards. Correlation and Bland-Altman analyses were conducted to compare both methods. RESULTS: DXA was feasible in all athletes, while the sums of 4, 7, and 8 skinfolds were obtained in 88%, 73%, and 73% of the athletes, respectively. Median DXA-derived body-fat percentage was 16.3% (13.4%-20.5%) in males and 27.8% (21.1%-33.4%) in females. Strong correlations were found between DXA-derived body-fat percentage and the sum of 4 (r = .85), 7 (r = .83), and 8 (r = .83) skinfolds. However, skinfold-based prediction equations for estimating body-fat percentage were associated with substantial negative bias (-2.0% to -7.9%) and large individual error compared with DXA. CONCLUSION: DXA is a feasible method for assessing body composition in Paralympic athletes, while ISAK skinfold measurements face some challenges due to disability-related landmarking issues. Despite these limitations, skinfold thickness remains strongly associated with DXA-derived body fat. It is recommended to measure all skinfolds that can be reliably obtained according to ISAK standards and interpret them as a cumulative "sum of feasible sites," rather than enforcing a universal skinfold metric across all Paralympic athletes. FAU - van Schijndel, Nick AU - van Schijndel N AUID- ORCID: 0009-0006-2714-9309 AD - School of Sport and Exercise, HAN University of Applied Sciences, Nijmegen, the Netherlands. FAU - Weijer, Vera AU - Weijer V AUID- ORCID: 0000-0003-0460-4955 AD - School of Sport and Exercise, HAN University of Applied Sciences, Nijmegen, the Netherlands. FAU - van Loon, Luc J C AU - van Loon LJC AUID- ORCID: 0000-0002-6768-9231 AD - Department of Human Biology, NUTRIM, Maastricht University Medical Center+, Maastricht, the Netherlands. FAU - van Dijk, Jan-Willem AU - van Dijk JW AUID- ORCID: 0000-0001-9674-1505 AD - School of Sport and Exercise, HAN University of Applied Sciences, Nijmegen, the Netherlands. LA - eng PT - Comparative Study PT - Journal Article DEP - 20251215 PL - United States TA - Int J Sports Physiol Perform JT - International journal of sports physiology and performance JID - 101276430 SB - IM MH - Humans MH - *Absorptiometry, Photon MH - Male MH - Female MH - *Skinfold Thickness MH - Cross-Sectional Studies MH - Feasibility Studies MH - Young Adult MH - Adult MH - *Para-Athletes MH - *Sports for Persons with Disabilities MH - Body Composition MH - *Adipose Tissue/diagnostic imaging MH - Athletes MH - Adolescent OTO - NOTNLM OT - DXA OT - anthropometry OT - body composition OT - disabled athletes EDAT- 2025/12/30 19:11 MHDA- 2026/01/27 12:58 CRDT- 2025/12/30 12:24 PHST- 2025/06/19 00:00 [received] PHST- 2025/10/28 00:00 [revised] PHST- 2025/10/28 00:00 [accepted] PHST- 2026/01/27 12:58 [medline] PHST- 2025/12/30 19:11 [pubmed] PHST- 2025/12/30 12:24 [entrez] AID - 10.1123/ijspp.2025-0284 [doi] PST - epublish SO - Int J Sports Physiol Perform. 2025 Dec 15;21(2):241-251. doi: 10.1123/ijspp.2025-0284. Print 2026 Feb 1. PMID- 41466396 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260627 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 25 IP - 1 DP - 2025 Dec 29 TI - Toothbrushing ability, caries burden, and oral health-related quality of life among stunted preschool children in Bandung-Indonesia. PG - 1958 LID - 10.1186/s12903-025-07307-1 [doi] LID - 1958 AB - BACKGROUND: Stunting remains a significant public health challenge in Indonesia and may affect children's neuromotor development, including fine motor coordination required for effective toothbrushing. Impaired oral hygiene behaviors in stunted children may contribute to increased caries burden and reduced oral health-related quality of life (OHRQoL). OBJECTIVE: To investigate the relationship between toothbrushing ability, caries burden, and OHRQoL among stunted and non-stunted preschool children in Bandung, Indonesia. METHODS: A cross-sectional study was conducted among 554 children aged 1-5 years selected through consecutive sampling from identified stunting loci. Clinical assessments of caries (def-t index) and oral hygiene (Debris Index from OHI-S) were conducted by calibrated dentists. Toothbrushing ability was assessed using a structured checklist, and OHRQoL was assessed using the validated Indonesian version of the Parental-Caregiver Perception Questionnaire (P-CPQ). Statistical analyses included descriptive statistics and chi-square tests to examine bivariate associations, with linear-by-linear association tests for ordinal variables. RESULTS: Nutritional status was significantly associated with toothbrushing ability (p = 0.034) and OHRQoL (p < 0.001), but not with caries burden (p = 0.924). Toothbrushing ability was significantly associated with caries burden (p < 0.001) and oral hygiene (p < 0.001). Oral hygiene was also associated with caries burden (p < 0.001). Brushing frequency (p = 0.048) and technique (p = 0.027) differed significantly by nutritional status, whereas brushing duration, parental assistance, and grip type did not. No significant associations were observed between caries burden, oral hygiene, toothbrushing ability, and OHRQoL, likely due to the highly skewed distribution of OHRQoL categories, with 97.5% classified as "very low impact." CONCLUSION: Stunted children demonstrated poorer toothbrushing ability compared to their non-stunted peers, and caries burden was closely related to oral hygiene and brushing practices. Nutritional status was associated with OHRQoL, although other variables showed no significant relationship due to limited variability in OHRQoL scores. Integrating oral health promotion with nutrition improvement programs may support better oral and general health outcomes among nutritionally vulnerable populations. FAU - Setiawan, Arlette Suzy AU - Setiawan AS AD - Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia. arlette.puspa@unpad.ac.id. FAU - Atmadja, Irene Tanesha AU - Atmadja IT AD - Dentistry Education Program, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia. FAU - Andisetyanto, Prima AU - Andisetyanto P AD - Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia. FAU - Indriyanti, Ratna AU - Indriyanti R AD - Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia. FAU - Suryanti, Netty AU - Suryanti N AD - Department of Community Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia. FAU - Juniarti, Neti AU - Juniarti N AD - Faculty of Nursing, Universitas Padjadjaran, Bandung, Indonesia. FAU - Rahayuwati, Laili AU - Rahayuwati L AD - Faculty of Nursing, Universitas Padjadjaran, Bandung, Indonesia. LA - eng PT - Journal Article DEP - 20251229 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - Indonesia/epidemiology MH - *Quality of Life MH - Child, Preschool MH - *Dental Caries/epidemiology MH - *Toothbrushing/statistics & numerical data MH - Cross-Sectional Studies MH - *Oral Health MH - Female MH - Male MH - Infant MH - *Growth Disorders/epidemiology/complications MH - Nutritional Status PMC - PMC12750588 OTO - NOTNLM OT - Children's motor skills OT - Stunting OT - Tooth brushing skills COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the ethical standards of the Health Research Ethics Committee of Universitas Padjadjaran and with the 1964 Helsinki Declaration and its later amendments. Ethical approval was obtained under reference number 517/UN6.KEP/EC/2023 and extended with number 855/UN6.KEP/EC/2024. Written informed consent was obtained from all participants and/or their legal guardians prior to participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/30 07:40 MHDA- 2026/06/28 00:36 PMCR- 2025/12/29 CRDT- 2025/12/30 02:47 PHST- 2025/06/27 00:00 [received] PHST- 2025/11/11 00:00 [accepted] PHST- 2026/06/28 00:36 [medline] PHST- 2025/12/30 07:40 [pubmed] PHST- 2025/12/30 02:47 [entrez] PHST- 2025/12/29 00:00 [pmc-release] AID - 10.1186/s12903-025-07307-1 [pii] AID - 7307 [pii] AID - 10.1186/s12903-025-07307-1 [doi] PST - epublish SO - BMC Oral Health. 2025 Dec 29;25(1):1958. doi: 10.1186/s12903-025-07307-1. PMID- 41466326 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 13 IP - 1 DP - 2025 Dec 29 TI - The influences of physical activities on college students' SWB: based on the mediating effect of subjectively perceived health and the moderating effect of implicit mentality. PG - 1385 LID - 10.1186/s40359-025-03623-x [doi] LID - 1385 AB - BACKGROUND: In recent years, with the increase of mental health burden on Chinese college students, the level of SWB (subjective perception of well-being)has been decreasing. However, physical activities have been verified to have a significant positive impact on the physical and mental health of individuals. METHOD: In this paper, questionnaire was used to conduct three substudies and one supplementary study. Among them, Study One examined the relationship between physical activities and SWB among college students, with a total of 244 college students completing the study; On the basis of Study 1, Study 2 examined the mediating effect of subjectively perceived health on the relationships between physical activities and SWB among college students. A total of 248 college students completed the study; Based on Study 2 and Study 3, the moderating role of implicit mentality in this process of mediation was examined, with a total of 280 college students completing the study; A supplementary study was conducted to further validate the applicability of the research mechanism by changing the measurement scales of variables. A total of 332 college students completed the study. RESULTS: (1) physical activities positively affect SWB, i.e., the higher the level of physical activities, the stronger SWB; (2) subjectively perceived health partially mediates the relationship between physical activities and SWB among college students, i.e., the higher level of physical activities, the higher level of subjectively perceived health for the college students, which in turn lead to higher SWB; and (3) the implicit mentality moderates the first stage of this mediating pathway and also has a direct influence on the relationship between physical activities and SWB. CONCLUSION: (1) The implicit mentality moderates the relationship between physical activity and subjectively perceived health. Compared with college students with a fixed mentality, those with a developing one exhibit greater subjectively perceived health while being more involved in physical activities, which in turn contributes to the enhanced SWB; (2) The implicit mentality also moderates the association between physical activities and SWB. Relative to students with a fixed mentality, students with a developing one are more engaged in physical activities and reported to have higher levels of SWB; (3) Physical activities serve as a positive restorative mechanism for alleviating physiological and psychological stress among college students, thereby exerting a beneficial influence on overall well-being. FAU - Tang, Gang AU - Tang G AD - Graduate School of Economics and Management, Chengdu Sport University, Chengdu, 610041, China. 1926768241@qq.com. FAU - Tang, Peijie AU - Tang P AD - P. E. Dept., China West Normal University, Nanchong, 637002, China. LA - eng PT - Journal Article DEP - 20251229 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - *Students/psychology MH - Female MH - Male MH - Young Adult MH - *Exercise/psychology MH - Universities MH - Psychological Well-Being MH - Adult MH - Surveys and Questionnaires MH - *Health Status MH - Adolescent PMC - PMC12752288 OTO - NOTNLM OT - Implicit mentality OT - Physical activities OT - SWB OT - Subjectively perceived health COIS- Declarations. Ethics approval and consent to participation: Our research has been approved by the Ethics Committee of China West Normal University, review form number 2025LLSC0058. Moreover, it does not involve clinical trials on animals or humans, and therefore, it is not unethical. All participants obtained informed consent before participating in the study. A written consent form was provided to the participants, detailing the research purpose, procedures and the right to withdraw at any time. Consent for publication: All authors approved the final manuscript and the submission to this journal. Competing interests: The authors declare no competing interests. EDAT- 2025/12/30 07:41 MHDA- 2026/06/27 00:49 PMCR- 2025/12/29 CRDT- 2025/12/30 02:42 PHST- 2025/05/26 00:00 [received] PHST- 2025/10/25 00:00 [accepted] PHST- 2026/06/27 00:49 [medline] PHST- 2025/12/30 07:41 [pubmed] PHST- 2025/12/30 02:42 [entrez] PHST- 2025/12/29 00:00 [pmc-release] AID - 10.1186/s40359-025-03623-x [pii] AID - 3623 [pii] AID - 10.1186/s40359-025-03623-x [doi] PST - epublish SO - BMC Psychol. 2025 Dec 29;13(1):1385. doi: 10.1186/s40359-025-03623-x. PMID- 41466323 OWN - NLM STAT- MEDLINE DCOM- 20251230 LR - 20260926 IS - 1880-6805 (Electronic) IS - 1880-6791 (Print) IS - 1880-6791 (Linking) VI - 44 IP - 1 DP - 2025 Dec 29 TI - A theoretical model of secular body mass index dynamics among Russian adults under changing socio-economic conditions. PG - 34 LID - 10.1186/s40101-025-00415-5 [doi] LID - 34 AB - BACKGROUND: Body mass index (BMI) is a key indicator of population health and often shifts alongside socio-economic change. Few studies have tracked these dynamics over long periods in transitional economies. Russia's late-twentieth-century transformations offer a rare opportunity to examine such links. This study develops and validates a time-series model of BMI in 19 years old, relating changes in socio-economic and demographic indicators to BMI trends and producing scenario-based forecasts. MATERIALS AND METHODS: We analyzed national time-series data published by the NCD Risk Factor Collaboration for 1975-2016 (males and females, age 19), along with indicators of urbanization, fertility, infant and all-cause mortality, life expectancy, and nutritional proxies (protein supply, animal-source calories, meat). Predictors were standardized. Per sex, we estimated the following: (i) first-difference OLS, (ii) dynamic regressions with a lagged BMI term (ARDL(1,0)), and (iii) smooth-trend models with a natural cubic spline in year. Diagnostics included augmented Dickey-Fuller and Durbin-Watson tests. Model selection triangulated elastic net, partial least squares, and stepwise regression. Rolling-origin one-step-ahead forecasts used only information available at time t; bootstrap resampling assessed sign stability. RESULTS: Across specifications, the urbanization share was the most robust correlate of BMI. For males, higher urbanization was consistently and inversely associated with BMI; for females, the association was small and model sensitive (frequently negative but not uniformly significant). Effects of life expectancy and mortality attenuated and often lost significance once smooth time structure was included, indicating shared long-run movement rather than distinct short-run covariation; infant mortality added little independent signal. Nutrition proxies contributed limited, non-robust information. ARDL(1,0) one-step-ahead forecasts outperformed random-walk and trend-only baselines. Under a baseline scenario (continuation of recent socio-economic patterns), projected BMI in 2050 is approximately 26.6 kg/m(2) (males) and 26.7 kg/m(2) (females). Forecasts use only information available at time t (lagged predictors/nowcasts) and are conditional on assumed exogenous trajectories; longer-horizon projections are scenario based rather than unconditional. CONCLUSIONS: After explicit treatment of nonstationarity, macrodemographic structure, especially urbanization, shows the most consistent links to BMI at age 19, whereas national-scale nutrition proxies are weak at this grain. Findings are descriptive, not causal; forecasts should be interpreted with caution. Incorporating finer-grained behavioral, dietary, and environmental data will help clarify mechanisms and improve long-term forecasting. CI - (c) 2025. The Author(s). FAU - Negasheva, Marina A AU - Negasheva MA AD - Department of Anthropology, Lomonosov State University, Moscow, Russia. FAU - Kuznetsova, Olga A AU - Kuznetsova OA AD - Department of Anthropology, Lomonosov State University, Moscow, Russia. FAU - Khafizova, Ainur A AU - Khafizova AA AD - Department of Anthropology, Lomonosov State University, Moscow, Russia. FAU - Movsesian, Alla A AU - Movsesian AA AD - Department of Anthropology, Lomonosov State University, Moscow, Russia. amovsessyan@gmail.com. LA - eng GR - 23-18-00086/Russian Science Foundation/ PT - Journal Article DEP - 20251229 PL - England TA - J Physiol Anthropol JT - Journal of physiological anthropology JID - 101269653 SB - IM MH - Humans MH - *Body Mass Index MH - Russia/epidemiology MH - Female MH - Male MH - Young Adult MH - Adult MH - Socioeconomic Factors MH - Models, Theoretical MH - Anthropology, Physical MH - Middle Aged PMC - PMC12750930 OTO - NOTNLM OT - Body mass index OT - Regression modeling OT - Russia OT - Secular trend OT - Socio-economic factors COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/30 07:41 MHDA- 2025/12/30 13:11 PMCR- 2025/12/29 CRDT- 2025/12/30 02:42 PHST- 2025/04/26 00:00 [received] PHST- 2025/11/06 00:00 [accepted] PHST- 2025/12/30 13:11 [medline] PHST- 2025/12/30 07:41 [pubmed] PHST- 2025/12/30 02:42 [entrez] PHST- 2025/12/29 00:00 [pmc-release] AID - 10.1186/s40101-025-00415-5 [pii] AID - 415 [pii] AID - 10.1186/s40101-025-00415-5 [doi] PST - epublish SO - J Physiol Anthropol. 2025 Dec 29;44(1):34. doi: 10.1186/s40101-025-00415-5. PMID- 41466147 OWN - NLM STAT- MEDLINE DCOM- 20261005 LR - 20261008 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) VI - 100 IP - 2 DP - 2026 Jul TI - An assessment of methods for measuring body composition in full-term infants: A systematic review. PG - 674-687 LID - 10.1038/s41390-025-04717-3 [doi] AB - BACKGROUND: Numerous methods are available for measuring body composition in infants, however, there is no consensus on which approach is preferred. The aim of this study was to identify one such method for a clinical and research setting. METHODS: A systematic search was conducted on PubMed, Embase, and Cochrane Library to identify studies that investigated the accuracy of body composition methods in full-term infants up to 2 years of age. RESULTS: Thirty out of 6643 identified records were included. Several anthropometric equations were investigated with inconsistent results. Dual-energy X-ray absorptiometry (DXA) and bioelectrical impedance analysis (BIA) showed more comparable results to those assessed by air displacement plethysmography (ADP), when applying new techniques. Few studies assessed the accuracy of quantitative magnetic resonance (QMR), isotope dilution, and near-infrared spectroscopy (NIR); nonetheless, they all performed well against reference methods. ADP showed agreement compared to deuterium dilution, 3-compartment-, and 4-compartment-models on group-level; however, there were discrepancies when compared to DXA. CONCLUSIONS: Anthropometry, DXA, BIA, and ultrasound showed varying results, highlighting the need for further research. QMR, isotope dilution, and NIR appeared promising, but evidence is limited due to few studies. ADP showed consistently small bias compared to multi-component models and isotope dilution. IMPACT: Accurate body composition assessment in infancy has the potential to improve prophylactic actions against obesity. There is relative consensus on the most accurate body composition assessment in pre-term infants in a research setting, however, this consensus has not been available for full-term infants until now. Measure of anthropometry performs with varying precision, suggesting very low feasibility of the method for body composition assessment. From a research perspective, air displacement plethysmography is an accurate method for measuring body composition in full-term infants. This systematic review identifies research gaps within the scientific field of infant body composition. CI - (c) 2025. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - Schiodt, Signe AU - Schiodt S AD - Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark. signe.schioedt@gmail.com. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. signe.schioedt@gmail.com. FAU - Hviid, Kathrine V R AU - Hviid KVR AD - Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. FAU - Geiker, Nina R W AU - Geiker NRW AD - Centre for Childhood Health, Copenhagen, Denmark. FAU - Banasik, Karina AU - Banasik K AD - Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark. AD - Department of Health Technology, Technical University of Denmark, Lyngby, Denmark. FAU - Westergaard, David AU - Westergaard D AD - Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark. AD - Department of Health Technology, Technical University of Denmark, Lyngby, Denmark. FAU - Nielsen, Henriette S AU - Nielsen HS AD - Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark. AD - Department of Health Technology, Technical University of Denmark, Lyngby, Denmark. LA - eng PT - Journal Article PT - Systematic Review DEP - 20251229 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM MH - Humans MH - *Body Composition MH - Infant MH - Absorptiometry, Photon MH - *Anthropometry/methods MH - Infant, Newborn MH - Electric Impedance MH - Plethysmography MH - Spectroscopy, Near-Infrared MH - Ultrasonography MH - Female MH - Reproducibility of Results MH - Male COIS- Competing interests: The authors declare no competing interests. Consent statement: Patient consent was not required for this systematic review. EDAT- 2025/12/30 07:41 MHDA- 2026/10/06 05:29 CRDT- 2025/12/30 02:26 PHST- 2025/06/20 00:00 [received] PHST- 2025/11/20 00:00 [accepted] PHST- 2025/10/28 00:00 [revised] PHST- 2026/10/06 05:29 [medline] PHST- 2025/12/30 07:41 [pubmed] PHST- 2025/12/30 02:26 [entrez] AID - 10.1038/s41390-025-04717-3 [pii] AID - 10.1038/s41390-025-04717-3 [doi] PST - ppublish SO - Pediatr Res. 2026 Jul;100(2):674-687. doi: 10.1038/s41390-025-04717-3. Epub 2025 Dec 29. PMID- 41464844 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251230 LR - 20260102 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 14 IP - 24 DP - 2025 Dec 18 TI - Biomarkers of Sarcopenia and Sarcopenic Obesity in Renal Transplant Recipients: A Systematic Review and Evidence Quality Assessment. LID - 10.3390/jcm14248943 [doi] LID - 8943 AB - Background: Sarcopenia and sarcopenic obesity are increasingly recognized in kidney transplant recipients (KTRs), yet their molecular underpinnings remain poorly defined. We sought to synthesize current evidence on biomarker associations with muscle loss and function in the post renal transplant setting. Methods: A comprehensive search of PubMed/MEDLINE and Cochrane databases was conducted according to PRISMA guidelines. Studies evaluating biomarkers related to sarcopenia or sarcopenic obesity in adult and pediatric KTRs were included. Quality assessment was performed with the NHLBI tool. Results: Seven studies were included, encompassing 548 KTRs. Myostatin levels predicted sarcopenia in KTRs (cut-off: 390 pg/mL) and inversely correlated with Metabolic equivalent of Tasks (METs), handgrip strength (HGS), and graft performance. Although adiponectin was negatively correlated with body fat, its high-molecular-weight isoform was linked to lower muscle mass and long-term graft decline. Leptin was associated with sarcopenic obesity and lower estimated Glomerular Filtration Rate (eGFR). Insulin like Growth Factor-1 (IGF-1) independently predicted HGS but not muscle mass. Brain-derived neurotrophic factor (BDNF) levels predicted sarcopenia (cut off: 17.8 ng/mL) and reflected physical activity levels. Visfatin showed no association with sarcopenia but it was positively correlated with eGFR. Lastly, certain polymorphisms of Alpha-actinin-3 (ACTN3) were shown to genetically predispose to post-transplant sarcopenia. Conclusions: These emerging candidate biomarkers provide promising mechanistic insight into post-transplant muscle decline and may ultimately support more personalized risk assessment. Further validation is needed, and functional measures remain the most reliable clinical tools at present. FAU - Soukouli, Ioanna AU - Soukouli I AD - Department of Nephrology and Renal Transplantation, Laiko General Hospital, National and Kapodistrian University of Athens, 157 71 Athens, Greece. FAU - Karagkounis, Thomas AU - Karagkounis T AUID- ORCID: 0009-0001-8622-8967 AD - Surgery Working Group, Society of Junior Doctors, 155 71 Athens, Greece. FAU - Mylonas, Konstantinos S AU - Mylonas KS AUID- ORCID: 0000-0002-2356-6694 AD - Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA. FAU - Kalathas, Theofanis AU - Kalathas T AD - Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA. FAU - Poulia, Kalliopi-Anna AU - Poulia KA AUID- ORCID: 0000-0002-0023-8102 AD - Laboratory of Dietetics and Quality of Life, Agricultural University of Athens, 155 71 Athens, Greece. FAU - Kokkinos, Alexander AU - Kokkinos A AD - First Department of Propaedeutic and Internal Medicine, Laiko General Hospital, Athens University Medical School, 155 71 Athens, Greece. FAU - Marinaki, Smaragdi AU - Marinaki S AD - Department of Nephrology and Renal Transplantation, Laiko General Hospital, National and Kapodistrian University of Athens, 157 71 Athens, Greece. LA - eng PT - Journal Article PT - Review DEP - 20251218 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC12734315 OTO - NOTNLM OT - BDNF OT - Insulin like Growth Factor-1 OT - adiponectin OT - biomarker OT - kidney transplant OT - leptin OT - myostatin OT - renal transplant OT - sarcopenia OT - sarcopenic obesity COIS- The authors declare no conflicts of interest. EDAT- 2025/12/30 07:40 MHDA- 2025/12/30 07:41 PMCR- 2025/12/18 CRDT- 2025/12/30 02:03 PHST- 2025/11/25 00:00 [received] PHST- 2025/12/12 00:00 [revised] PHST- 2025/12/15 00:00 [accepted] PHST- 2025/12/30 07:41 [medline] PHST- 2025/12/30 07:40 [pubmed] PHST- 2025/12/30 02:03 [entrez] PHST- 2025/12/18 00:00 [pmc-release] AID - jcm14248943 [pii] AID - jcm-14-08943 [pii] AID - 10.3390/jcm14248943 [doi] PST - epublish SO - J Clin Med. 2025 Dec 18;14(24):8943. doi: 10.3390/jcm14248943. PMID- 41464424 OWN - NLM STAT- MEDLINE DCOM- 20251230 LR - 20260824 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 22 IP - 12 DP - 2025 Nov 26 TI - The Influence of Parental Behaviours and Socioeconomic Factors on Offspring's Precursors of Atherosclerosis: A Systematic Review and Meta-Analysis of Observational Studies. LID - 10.3390/ijerph22121791 [doi] LID - 1791 AB - Parents can influence both the behaviours and cardiovascular health of their school-aged children and adolescents. Understanding these effects is essential for developing targeted interventions. This systematic review and meta-analysis aims to report existing research findings on the associations between parental lifestyle behaviours, socioeconomic status (SES), and educational level (EDL) and offspring's arterial stiffness (AS) and blood pressure (BP). Following PRISMA methodology, 19 observational studies were selected from the PubMed, Scopus, and EBSCO databases. Inclusion criteria focused on age range, children's AS and BP, parental behaviours, SES, and EDL. The STROBE checklist ensured the quality and reliability of the included studies. The meta-analysis included data from three or more studies. Higher levels of maternal physical activity were associated with lower AS in offspring. Parental smoking was associated with increased AS and higher BP in offspring. The meta-analyses showed that a lower EDL was associated with higher AS in offspring, 0.22 (95% CI: 0.15, 0.29; p < 0.001). No significant associations were found between parental SES and offspring's systolic (p = 0.40) and diastolic (p = 0.50) BP. Parental behaviours shape offspring's cardiovascular health. Parental physical activity and higher EDL seem to be protective, while parental smoking is associated with adverse outcomes. Further research is needed to clarify these relationships. FAU - Silva, Ana Carvalhinho AU - Silva AC AUID- ORCID: 0000-0002-1054-0831 AD - Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), University of Maia (UMaia), 4475-690 Maia, Portugal. FAU - Maia, Filipe AU - Maia F AUID- ORCID: 0000-0002-4026-3804 AD - Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), University of Maia (UMaia), 4475-690 Maia, Portugal. FAU - Estima, Francisco AU - Estima F AUID- ORCID: 0009-0007-5052-9710 AD - Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), University of Maia (UMaia), 4475-690 Maia, Portugal. FAU - Gaya, Anelise AU - Gaya A AUID- ORCID: 0000-0002-8335-6947 AD - Graduate Program in Human Movement Sciences, Federal University of Rio Grande do Sul (PPGCMH-UFRGS), Porto Alegre 90690-200, RS, Brazil. AD - School of Physical Education and Physiotherapy, Federal University of Pelotas (ESEF-UFPEL), Pelotas 96055-630, RS, Brazil. FAU - Christofaro, Diego AU - Christofaro D AUID- ORCID: 0000-0001-9917-9992 AD - Graduate Program in Movement Sciences, Department of Physical Education, School of Technology and Sciences, Sao Paulo State University (PPGCM-FCT-UNESP), Presidente Prudente 19060-900, SP, Brazil. FAU - Mota, Jorge AU - Mota J AUID- ORCID: 0000-0001-7571-9181 AD - Research Centre in Physical Activity, Health, and Leisure (CIAFEL), Faculty of Sport, University of Porto (FADE-UP), 4050-313 Porto, Portugal. AD - Laboratory for Integrative and Translational Research in Population Health (ITR), 4050-091 Porto, Portugal. FAU - Aires, Luisa AU - Aires L AUID- ORCID: 0000-0001-9717-4186 AD - Research Centre in Physical Activity, Health, and Leisure (CIAFEL), Faculty of Sport, University of Porto (FADE-UP), 4050-313 Porto, Portugal. AD - Laboratory for Integrative and Translational Research in Population Health (ITR), 4050-091 Porto, Portugal. FAU - Silva, Gustavo AU - Silva G AUID- ORCID: 0000-0003-3930-7037 AD - Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), University of Maia (UMaia), 4475-690 Maia, Portugal. LA - eng GR - UID/04045/Portuguese Foundation for Science and Technology (FCT)/ GR - 2022.14139.BD/Portuguese Foundation for Science and Technology (FCT)/ PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Systematic Review DEP - 20251126 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - *Atherosclerosis/epidemiology/etiology MH - Blood Pressure MH - Exercise MH - Life Style MH - Observational Studies as Topic MH - *Parents MH - Socioeconomic Factors MH - Vascular Stiffness PMC - PMC12732730 OTO - NOTNLM OT - adolescents OT - arterial stiffness OT - blood pressure OT - children OT - educational level OT - parents OT - socioeconomic status COIS- The authors declare no conflicts of interest. EDAT- 2025/12/30 07:41 MHDA- 2025/12/30 07:42 PMCR- 2025/11/26 CRDT- 2025/12/30 01:58 PHST- 2025/08/21 00:00 [received] PHST- 2025/11/12 00:00 [revised] PHST- 2025/11/19 00:00 [accepted] PHST- 2025/12/30 07:42 [medline] PHST- 2025/12/30 07:41 [pubmed] PHST- 2025/12/30 01:58 [entrez] PHST- 2025/11/26 00:00 [pmc-release] AID - ijerph22121791 [pii] AID - ijerph-22-01791 [pii] AID - 10.3390/ijerph22121791 [doi] PST - epublish SO - Int J Environ Res Public Health. 2025 Nov 26;22(12):1791. doi: 10.3390/ijerph22121791. PMID- 41464369 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251230 LR - 20260102 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 13 IP - 24 DP - 2025 Dec 16 TI - Artificial Intelligence in Sub-Elite Youth Football Players: Predicting Recovery Through Machine Learning Integration of Physical, Technical, Tactical and Maturational Data. LID - 10.3390/healthcare13243301 [doi] LID - 3301 AB - Background: Monitoring training load and recovery is essential for performance optimization and injury prevention in youth football. However, predicting subjective recovery in preadolescent athletes remains challenging due to biological variability and the multidimensional nature of training responses. This exploratory study examined whether supervised machine learning (ML) models could predict Total Quality of Recovery (TQR) using integrated external load, internal load, anthropometric and maturational variables collected over one competitive microcycle. Methods: Forty male sub-elite U11 and U13 football players (age 10.3 +/- 0.7 years; height 1.43 +/- 0.08 m; body mass 38.6 +/- 6.2 kg; BMI 18.7 +/- 2.1 kg/m(2)) completed a microcycle comprising four training sessions (MD-4 to MD-1) and one official match (MD). A total of 158 performance-related variables were extracted, including external load (GPS-derived metrics), internal load (RPE and sRPE), heart rate indicators (U13 only), anthropometric and maturational measures, and tactical-cognitive indices (FUT-SAT). After preprocessing and aggregation at the player level, five supervised ML algorithms-K-Nearest Neighbors (KNN), Support Vector Machine (SVM), Decision Tree (DT), Random Forest (RF), and Gradient Boosting (GB)-were trained using a 70/30 train-test split and 5-fold cross-validation to classify TQR into Low, Moderate, and High categories. Results: Tree-based models (DT, GB) demonstrated the highest predictive performance, whereas linear and distance-based approaches (SVM, KNN) showed lower discriminative ability. Anthropometric and maturational factors emerged as the most influential predictors of TQR, with external and internal load contributing modestly. Predictive accuracy was moderate, reflecting the developmental variability characteristics of this age group. Conclusions: Using combined physiological, mechanical, and maturational data, these ML-based monitoring systems can simulate subjective recovery in young football players, offering potential as decision-support tools in youth sub-elite football and encouraging a more holistic and individualized approach to training and recovery management. FAU - Afonso, Pedro AU - Afonso P AUID- ORCID: 0009-0000-1077-7233 AD - Biosciences Higher School of Elvas, Polytechnic Institute of Portalegre, 7300-110 Portalegre, Portugal. AD - Department of Sport, Exercise and Health Sciences, University of Tras-os-Montes e Alto Douro, 5000-801 Vila Real, Portugal. AD - Research Centre for Active Living and Wellbeing (Livewell), Instituto Politecnico de Braganca, 5300-253 Braganca, Portugal. AD - Department of Sports, Higher Institute of Educational Sciences of the Douro, 4560-708 Penafiel, Portugal. FAU - Forte, Pedro AU - Forte P AUID- ORCID: 0000-0003-0184-6780 AD - Research Centre for Active Living and Wellbeing (Livewell), Instituto Politecnico de Braganca, 5300-253 Braganca, Portugal. AD - CI-ISCE, ISCE Douro, 4560-547 Penafiel, Portugal. AD - Department of Sports Sciences, Instituto Politecnico de Braganca, 5300-252 Braganca, Portugal. FAU - Branquinho, Luis AU - Branquinho L AUID- ORCID: 0000-0001-9000-5419 AD - Biosciences Higher School of Elvas, Polytechnic Institute of Portalegre, 7300-110 Portalegre, Portugal. AD - Life Quality Research Center (LQRC-CIEQV), 2001-964 Santarem, Portugal. FAU - Ferraz, Ricardo AU - Ferraz R AUID- ORCID: 0000-0002-7530-512X AD - Department of Sport Sciences, University of Beira Interior, 6201-001 Covilha, Portugal. AD - Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), 5000-801 Vila Real, Portugal. FAU - Garrido, Nuno Domingues AU - Garrido ND AUID- ORCID: 0000-0002-8105-7580 AD - Department of Sport, Exercise and Health Sciences, University of Tras-os-Montes e Alto Douro, 5000-801 Vila Real, Portugal. AD - Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), 5000-801 Vila Real, Portugal. FAU - Teixeira, Jose Eduardo AU - Teixeira JE AUID- ORCID: 0000-0003-4612-3623 AD - Department of Sports Sciences, Polytechnic Institute of Guarda, 6300-559 Guarda, Portugal. AD - Department of Sports Sciences, Polytechnic of Cavado and Ave, 4750-810 Guimaraes, Portugal. AD - SPRINT-Sport Physical Activity and Health Research & Innovation Center, 6300-559 Guarda, Portugal. LA - eng GR - project UID/CED/04748/2020, UIDB04045/2021 and UID/6157/2025/FCT - Fundacao para a Ciencia e a Tecnologia, I.P.,/ PT - Journal Article DEP - 20251216 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12732887 OTO - NOTNLM OT - machine learning OT - maturation OT - performance OT - recovery OT - youth soccer COIS- The authors declare no conflicts of interest. EDAT- 2025/12/30 07:41 MHDA- 2025/12/30 07:42 PMCR- 2025/12/16 CRDT- 2025/12/30 01:58 PHST- 2025/11/10 00:00 [received] PHST- 2025/12/09 00:00 [revised] PHST- 2025/12/10 00:00 [accepted] PHST- 2025/12/30 07:42 [medline] PHST- 2025/12/30 07:41 [pubmed] PHST- 2025/12/30 01:58 [entrez] PHST- 2025/12/16 00:00 [pmc-release] AID - healthcare13243301 [pii] AID - healthcare-13-03301 [pii] AID - 10.3390/healthcare13243301 [doi] PST - epublish SO - Healthcare (Basel). 2025 Dec 16;13(24):3301. doi: 10.3390/healthcare13243301. PMID- 41464320 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251230 LR - 20260919 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 13 IP - 24 DP - 2025 Dec 11 TI - Feasibility and Preliminary Response of a Novel Training Program on Mobility Parameters in Adolescents with Movement Disorders. LID - 10.3390/healthcare13243251 [doi] LID - 3251 AB - Background: There is a critical need for feasible, non-equipment based, safe, and cost-effective exercise interventions to promote muscle strength, dynamic postural balance, and independent mobility in adolescents with cerebral palsy (CP) or spina bifida (SB). Objectives: This study aimed to examine the feasibility and preliminary response of a novel exercise program: Functionally Loaded High-Intensity Circuit Training (FUNHIT) and conventional High-Intensity Circuit Training (HIT) in adolescents with CP/SB. Methods: Enrolled participants were allocated to FUNHIT or HIT or Controls in our randomized control trial. The interventions were delivered 2x/week x 4 weeks. Feasibility was assessed through process, operational, and scientific metrics. Outcome measures included maximum walking speed, Four Square Step Test (FSST), Timed Up and Go (TUG) and its dual-task variants, Lateral Step-Up Test (LSUT), Fear of Falling (FoF) and physical activity (PA) questionnaires. Results: We tested 5 participants (1 CP, 4 SB) in our study. Recruitment and retention rates were acceptable (63% enrollment, 100% retention and adherence). FUNHIT (n = 2) participants showed improvements in maximum walking speed (8-12%), FSST (15-29%), LSUT (22-33%), and TUG (4%). The HIT participant (n = 1) demonstrated improved TUG dual-task performance (40%) and FSST (30%) only. Control participants (n = 2) had varied changes (from 0-24%) in mobility, strength, balance. No adverse events were reported. Participants successfully followed (100%) the prescribed exercise dosage over the four-week period. Conclusions: FUNHIT and HIT are feasible and safe interventions for adolescents with ambulatory CP and SB who retain motor function, showing promising preliminary improvements in muscle strength, dynamic balance, and independent mobility. Our findings need to be validated in larger samples. FAU - Quach, Phuong T M AU - Quach PTM AD - Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL 35294, USA. FAU - Fisher, Gordon AU - Fisher G AUID- ORCID: 0000-0002-9191-3774 AD - Department of Human Studies, University of Alabama at Birmingham, Birmingham, AL 35294, USA. FAU - Lai, Byron AU - Lai B AD - Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294, USA. FAU - Modlesky, Christopher M AU - Modlesky CM AD - Department of Kinesiology, University of Georgia, Athens, GA 30602, USA FAU - Hurt, Christopher P AU - Hurt CP AUID- ORCID: 0000-0001-8861-9876 AD - Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL 35294, USA. FAU - Bowersock, Collin D AU - Bowersock CD AD - Human Performance and Nutrition Research Institute, Oklahoma State University, Stillwater, OK 74077, USA. FAU - Boolani, Ali AU - Boolani A AUID- ORCID: 0000-0002-2261-4498 AD - Human Performance and Nutrition Research Institute, Oklahoma State University, Stillwater, OK 74077, USA. FAU - Singh, Harshvardhan AU - Singh H AUID- ORCID: 0000-0001-5945-8102 AD - Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL 35294, USA. AD - Human Performance and Nutrition Research Institute, Oklahoma State University, Stillwater, OK 74077, USA. LA - eng GR - C-PROGRESS/National Pediatric Rehabilitation Resource Center, USA/ PT - Journal Article DEP - 20251211 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12732486 OTO - NOTNLM OT - balance OT - cerebral palsy OT - exercise OT - intervention OT - neuromotor disorder OT - spina bifida COIS- The authors declare no conflicts of interest. EDAT- 2025/12/30 07:41 MHDA- 2025/12/30 07:42 PMCR- 2025/12/11 CRDT- 2025/12/30 01:57 PHST- 2025/08/24 00:00 [received] PHST- 2025/11/26 00:00 [revised] PHST- 2025/12/07 00:00 [accepted] PHST- 2025/12/30 07:42 [medline] PHST- 2025/12/30 07:41 [pubmed] PHST- 2025/12/30 01:57 [entrez] PHST- 2025/12/11 00:00 [pmc-release] AID - healthcare13243251 [pii] AID - healthcare-13-03251 [pii] AID - 10.3390/healthcare13243251 [doi] PST - epublish SO - Healthcare (Basel). 2025 Dec 11;13(24):3251. doi: 10.3390/healthcare13243251. PMID- 41463617 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251230 LR - 20260925 IS - 2306-5354 (Print) IS - 2306-5354 (Electronic) IS - 2306-5354 (Linking) VI - 12 IP - 12 DP - 2025 Dec 3 TI - Integration of Artificial Intelligence and Wearable Devices in Pediatric Clinical Care: A Review. LID - 10.3390/bioengineering12121320 [doi] LID - 1320 AB - Wearable devices are becoming widely applied in healthcare to enable continuous, noninvasive monitoring, but their use in pediatric populations remains relatively underexplored. This review synthesizes 36 clinical studies focused on pediatric hospital and outpatient wearables published between 2014 and 2025. Devices included wrist-worn trackers, adhesive biosensors, and more, capturing electrocardiography, photoplethysmography, accelerometry, and other signals. Clinical applications spanned a variety of care settings. Artificial intelligence (AI) partially enhanced interpretation for the early detection of conditions such as postoperative complications and sepsis. Despite their promising accuracy, most studies remain small, single-center pilots focused on feasibility and signal validity rather than outcomes such as mortality, readmission, or long-term recovery. Key barriers include pediatric-specific device design, motion-robust signal quality, regulatory clearance, workflow integration, and equitable adoption in low-resource settings. Ethical concerns such as privacy, consent, and incidental findings and regulatory constraints, particularly the lack of pediatric labeling and approval for consumer and AI-driven devices, further limit translation into practice. Future work should prioritize multi-center studies, multimodal analytics, explainable AI, and seamless integration into clinical pathways. With these advances, wearables can move beyond feasibility to become reliable, personalized tools that improve pediatric monitoring and care. FAU - Zheng, Huili AU - Zheng H AD - Windreich Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. AD - The Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. FAU - Sharma, Pragya AU - Sharma P AUID- ORCID: 0000-0003-2750-0147 AD - Windreich Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. AD - The Center for AI in Children's Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. FAU - Johnson, Matthew AU - Johnson M AUID- ORCID: 0000-0001-7056-2824 AD - Windreich Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. AD - The Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. FAU - Danieletto, Matteo AU - Danieletto M AUID- ORCID: 0000-0002-5178-9182 AD - Windreich Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. AD - The Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. FAU - Alleva, Eugenia AU - Alleva E AUID- ORCID: 0000-0003-3523-693X AD - Windreich Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. AD - The Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. FAU - Charney, Alexander W AU - Charney AW AUID- ORCID: 0000-0001-8135-6858 AD - Windreich Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. AD - The Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. FAU - Nadkarni, Girish N AU - Nadkarni GN AD - Windreich Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. AD - The Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. FAU - Sarabu, Chethan AU - Sarabu C AD - Health Tech Hub, Cornell Tech, Weill Cornell Medicine, New York, NY 10044, USA. FAU - Eskofier, Bjoern M AU - Eskofier BM AUID- ORCID: 0000-0002-0417-0336 AD - Institute of AI in Medicine, LMU Munich & LMU Hospital, 85152 Munich, Germany. AD - Institute of AI for Health, Helmholtz Munich, 85764 Neuherberg, Germany. FAU - Ahuja, Yuri AU - Ahuja Y AD - Windreich Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. FAU - Richter, Florian AU - Richter F AUID- ORCID: 0000-0002-7669-1923 AD - ArtemisAI Labs, Inc., San Francisco, CA 94102, USA. FAU - Klang, Eyal AU - Klang E AD - Windreich Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. AD - The Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. FAU - Gangadharan, Sandeep AU - Gangadharan S AD - The Center for AI in Children's Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. AD - Department of Pediatrics, Kravis Children's Hospital, New York, NY 10029, USA. FAU - Richter, Felix AU - Richter F AUID- ORCID: 0000-0003-3429-9621 AD - Windreich Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. AD - The Center for AI in Children's Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. AD - Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. FAU - Holmes, Emma AU - Holmes E AUID- ORCID: 0009-0001-3639-7631 AD - Windreich Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. AD - The Center for AI in Children's Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. FAU - Glicksberg, Benjamin S AU - Glicksberg BS AUID- ORCID: 0000-0003-4515-8090 AD - Windreich Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. AD - The Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. AD - The Center for AI in Children's Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. LA - eng PT - Journal Article PT - Review DEP - 20251203 PL - Switzerland TA - Bioengineering (Basel) JT - Bioengineering (Basel, Switzerland) JID - 101676056 PMC - PMC12729400 OTO - NOTNLM OT - artificial intelligence OT - biosignals OT - healthcare OT - pediatrics OT - wearable devices OT - wearables COIS- Author Florian Richter was employed by the company ArtemisAI Labs, Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/30 07:41 MHDA- 2025/12/30 07:42 PMCR- 2025/12/03 CRDT- 2025/12/30 01:49 PHST- 2025/10/16 00:00 [received] PHST- 2025/11/14 00:00 [revised] PHST- 2025/11/27 00:00 [accepted] PHST- 2025/12/30 07:42 [medline] PHST- 2025/12/30 07:41 [pubmed] PHST- 2025/12/30 01:49 [entrez] PHST- 2025/12/03 00:00 [pmc-release] AID - bioengineering12121320 [pii] AID - bioengineering-12-01320 [pii] AID - 10.3390/bioengineering12121320 [doi] PST - epublish SO - Bioengineering (Basel). 2025 Dec 3;12(12):1320. doi: 10.3390/bioengineering12121320. PMID- 41463299 OWN - NLM STAT- MEDLINE DCOM- 20251230 LR - 20260327 IS - 2218-273X (Electronic) IS - 2218-273X (Linking) VI - 15 IP - 12 DP - 2025 Nov 22 TI - The Possible Role of Neurofilament Light Chain as a Serum Biomarker in Anorexia Nervosa: Clinical Implications. LID - 10.3390/biom15121644 [doi] LID - 1644 AB - BACKGROUND: Neurofilament light chain (NfL) is a well-established biomarker of neuroaxonal damage, detectable in serum through immunoassays. Its potential relevance in psychiatric conditions, including anorexia nervosa (AN), is currently under investigation. This study aims to quantify serum NfL levels in individuals with AN, evaluate their correlation with autoantibodies detection, and critically examine the specificity of NfL as a biomarker in this context. METHODS: A total of 100 participants were enrolled, comprising 50 individuals diagnosed with AN and 50 age-matched, normal-weight controls. Serum concentrations of NfL and immunoglobulin G (IgG) antibodies reactive to hypothalamic antigens were measured using validated immunoassay techniques. RESULTS: Serum NfL concentrations were markedly higher in the AN group compared to healthy controls. Interestingly, NfL levels tended to decrease with longer disease duration and with the recovery of body mass index (BMI), indicating a possible association between clinical improvement and reduced neuroaxonal damage. Furthermore, the results confirmed the presence of anti-hypothalamic autoantibodies and revealed a positive correlation between their levels and serum NfL concentrations. CONCLUSIONS: Clinical remission in AN appears to be linked to a decrease in both markers neuronal damage and hypothalamic autoimmunity. However, as elevated serum NfL is observed across a spectrum of neurological and psychiatric disorders, its specificity as a biomarker for AN should be further investigated. While NfL may reflect neuroaxonal injury in AN, its interpretation should be contextualized within a broader clinical and immunological framework. FAU - Amerio, Andrea AU - Amerio A AUID- ORCID: 0000-0002-3439-340X AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), Section of Psychiatry, University of Genoa, 16132 Genoa, Italy. AD - IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy. FAU - Martino, Eleonora AU - Martino E AD - IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy. AD - Dietetics and Clinical Nutrition Unit, University of Genoa, 16132 Genoa, Italy. FAU - Strangio, Antonella AU - Strangio A AD - Department of Experimental Medicine (DiMeS), Section of Human Anatomy, University of Genoa, 16132 Genoa, Italy. FAU - Aguglia, Andrea AU - Aguglia A AUID- ORCID: 0000-0002-2003-2101 AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), Section of Psychiatry, University of Genoa, 16132 Genoa, Italy. AD - IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy. FAU - Conio, Benedetta AU - Conio B AD - IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy. FAU - Sukkar, Samir Giuseppe AU - Sukkar SG AUID- ORCID: 0000-0003-4194-1547 AD - IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy. AD - Dietetics and Clinical Nutrition Unit, University of Genoa, 16132 Genoa, Italy. FAU - Saverino, Daniele AU - Saverino D AUID- ORCID: 0000-0002-1623-1116 AD - IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy. AD - Department of Experimental Medicine (DiMeS), Section of Human Anatomy, University of Genoa, 16132 Genoa, Italy. LA - eng PT - Journal Article DEP - 20251122 PL - Switzerland TA - Biomolecules JT - Biomolecules JID - 101596414 RN - 0 (Neurofilament Proteins) RN - 0 (Biomarkers) RN - 0 (neurofilament protein L) RN - 0 (Autoantibodies) RN - 0 (Immunoglobulin G) SB - IM MH - Humans MH - *Anorexia Nervosa/blood MH - *Neurofilament Proteins/blood MH - *Biomarkers/blood MH - Female MH - Adult MH - Young Adult MH - Adolescent MH - Autoantibodies/blood MH - Male MH - Case-Control Studies MH - Hypothalamus/immunology/metabolism MH - Immunoglobulin G/blood PMC - PMC12730367 OTO - NOTNLM OT - anorexia nervosa OT - anti-hypothalamus antibody OT - neurofilament light chain COIS- The authors declare no conflicts of interest. EDAT- 2025/12/30 07:40 MHDA- 2025/12/30 07:41 PMCR- 2025/11/22 CRDT- 2025/12/30 01:45 PHST- 2025/10/20 00:00 [received] PHST- 2025/11/16 00:00 [revised] PHST- 2025/11/20 00:00 [accepted] PHST- 2025/12/30 07:41 [medline] PHST- 2025/12/30 07:40 [pubmed] PHST- 2025/12/30 01:45 [entrez] PHST- 2025/11/22 00:00 [pmc-release] AID - biom15121644 [pii] AID - biomolecules-15-01644 [pii] AID - 10.3390/biom15121644 [doi] PST - epublish SO - Biomolecules. 2025 Nov 22;15(12):1644. doi: 10.3390/biom15121644. PMID- 41462845 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251230 LR - 20260102 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 12 DP - 2025 Dec 17 TI - Targeting Pediatric Obesity Through Gender-Specific Nutritional Strategies: Insights from Dietary Intake and Food Sources. LID - 10.3390/children12121705 [doi] LID - 1705 AB - Background/Objectives: Childhood obesity remains a major global health challenge influenced by poor dietary patterns and excessive energy intake. Understanding gender-specific nutritional deviations may improve the effectiveness of preventive and therapeutic interventions. This study aimed to evaluate differences in energy and nutrient intake between boys and girls with overweight or obesity status and to identify the main food sources contributing to these differences. Methods: Data from a total of 180 participants (83 boys, 97 girls; 7-18 years) attending the national obesity intervention program Camp My Challenge was analyzed. Anthropometric parameters and dietary intake were assessed using a validated food-frequency questionnaire (OPKP). Intakes were compared with Slovenian dietary reference values (DRVs). Group differences were tested using ANOVA, t-tests, and Pearson correlations (p < 0.05). Results: Boys exhibited higher body mass (79.9 +/- 22.6 kg vs. 69.2 +/- 19.1 kg; p = 0.001) and BMI (30.8 +/- 4.8 kg/m(2) vs. 28.5 +/- 4.4 kg/m(2); p = 0.001). Mean energy intake was 2543 +/- 1138 kcal/day, exceeding DRV by 16% (t = 3.31, p < 0.001). Girls exceeded energy requirements by 24.5% vs. 5.4% in boys (p = 0.019). Boys consumed significantly more total fat (106 +/- 61 g vs. 85 +/- 47 g; p = 0.014), saturated fatty acids (34 +/- 20 g vs. 27 +/- 13 g; p = 0.011), protein (119 +/- 63 g vs. 98 +/- 41 g; p = 0.008), and sodium (3628 +/- 2086 mg vs. 2852 +/- 1520 mg; p = 0.005). Girls showed higher sugar intake (208% vs. 166% of DRV; p = 0.032), mainly from sweet foods (24%) and fruit (26%), whereas beverages-predominantly isotonic drinks-accounted for 27% of boys' sugar intake. Sugar intake correlated with waist circumference (r = 0.305, p = 0.002) and fat mass (r = 0.272, p = 0.007) in girls. Sodium intake exceeded DRV sixfold in both sexes. Conclusions: Marked sex-specific dietary disparities exist among children with obesity. Interventions should target high sugar and energy intake in girls and excessive fat, sodium, and sugar-sweetened beverage consumption in boys to enhance the efficacy of pediatric obesity management. FAU - Jakus, Tadeja AU - Jakus T AUID- ORCID: 0000-0001-8784-9178 AD - Faculty of Health Sciences, University of Primorska, 6310 Izola, Slovenia. FAU - Franetic, Breda Prunk AU - Franetic BP AD - Red Cross Health Resort Slovenia, Debeli Rtic, 6280 Ankaran, Slovenia. FAU - Vatovec, Tamara Poklar AU - Vatovec TP AD - Faculty of Health Sciences, University of Primorska, 6310 Izola, Slovenia. LA - eng PT - Journal Article DEP - 20251217 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12731442 OTO - NOTNLM OT - childhood obesity OT - dietary OT - nutrition OT - sex-specific COIS- The authors declare no conflicts of interest. EDAT- 2025/12/30 07:41 MHDA- 2025/12/30 07:42 PMCR- 2025/12/17 CRDT- 2025/12/30 01:40 PHST- 2025/11/28 00:00 [received] PHST- 2025/12/11 00:00 [revised] PHST- 2025/12/13 00:00 [accepted] PHST- 2025/12/30 07:42 [medline] PHST- 2025/12/30 07:41 [pubmed] PHST- 2025/12/30 01:40 [entrez] PHST- 2025/12/17 00:00 [pmc-release] AID - children12121705 [pii] AID - children-12-01705 [pii] AID - 10.3390/children12121705 [doi] PST - epublish SO - Children (Basel). 2025 Dec 17;12(12):1705. doi: 10.3390/children12121705. PMID- 41462826 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251230 LR - 20260102 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 12 DP - 2025 Dec 11 TI - Eating Speed and Its Associations with Cardiometabolic Risk Factors in Children. LID - 10.3390/children12121686 [doi] LID - 1686 AB - Background/Objective: Mexico has experienced an increase in the prevalence of overweight and obesity among schoolchildren, predisposing them to type 2 diabetes mellitus. In addition, rapid eating has been increasingly implicated in the dysregulation of appetite control, greater energy intake, and adverse metabolic outcomes in children. Prior evidence indicates that a faster eating pace is associated with excess adiposity and lipid metabolism. This study aimed to compare cardiovascular risk factors (waist circumference, waist-to-height ratio, body mass index (BMI), and lipid profile) among school-aged Mexican children according to self-reported eating speed. Design: Cross-sectional observational study. Setting: Public elementary schools in Mexico. Participants: Ninety school-aged children (52.2% female) aged 6-12 years old. Eating speed was assessed using an adapted and validated self-administered questionnaire. Intervention: No intervention was applied; participants were classified into slow-, normal-, or fast-eating groups according to their usual eating speed as reported in the instrument, which includes questions regarding self-perception and family perception. Main Outcome Measure: The primary outcomes included anthropometric parameters (BMI, waist circumference, and waist-to-height ratio), blood pressure (systolic and diastolic), and biochemical markers of lipid metabolism (triglycerides, total cholesterol, and HDL cholesterol). Analysis: Descriptive statistics were computed, and comparisons across eating speed groups were performed using one-way ANOVA for continuous variables and chi-square tests for categorical data. Statistical significance was set at p < 0.05. Results: Among the 90 children evaluated, 17.7% were classified as fast eaters. Although gender differences in eating speed were not statistically significant (chi(2)= 4.607, p = 0.100), a higher proportion of boys were classified as fast eaters. Children in the fast-eating group exhibited significantly higher BMI (1.4 kg/m(2)), waist circumference (4 cm greater), and modest elevations in triglyceride and total cholesterol levels, alongside lower HDL cholesterol, relative to their slow-eating peers (all p < 0.05). Among all variables, only diastolic blood pressure differed significantly across groups (F = 3.92, p = 0.022), with fast eaters showing the highest values. Nevertheless BMI, waist circumference, triglyceride levels, and total cholesterol were not statistically significant in the logistic regression, and HDL cholesterol demonstrated an association close to 95% [0.051 (0.011-0.226)] to a protective factor against cardiometabolic events, estimating an effect size of 1.64 using Cohen's d, which is considered a large effect, when compared to their slower-eating peers. Conclusions and Implications: Faster eating speed was consistently associated with unfavorable anthropometric and lipid profile indicators, aligning with previous evidence linking rapid eating to early cardiometabolic alterations. These findings emphasize the relevance of including eating behavior assessments in pediatric cardiovascular risk screenings and prevention strategies. FAU - Gomez-Martinez, Manuel Abraham AU - Gomez-Martinez MA AUID- ORCID: 0000-0001-9460-0848 AD - Promotion and Education for Health and Food Research Group, Universidad La Salle Mexico, Benjamin Franklin 45, Colonia Condesa, Mexico City 06140, Mexico. AD - Public Health Department, Faculty of Medicine, National University of Mexico, Escolar 411A, Copilco Universidad, Coyoacan, Mexico City 04360, Mexico. FAU - Rodriguez-Vera, Diana AU - Rodriguez-Vera D AUID- ORCID: 0000-0002-5526-0489 AD - Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina del Instituto Politecnico Nacional, Plan de San Luis y Diaz Miron s/n, Mexico City 11340, Mexico. AD - Clinica de Nutricion Especializada Beke, Colonia San Sebastian, Texcoco 56130, Mexico. FAU - Mendoza, Gabriela Olivares AU - Mendoza GO AD - Programa de Maestria en Ciencia de los Alimentos y Nutricion Humana, Facultad de Ciencias Quimicas, Universidad La Salle Mexico, Mexico City 06140, Mexico. FAU - Lastiri, Fernanda Lobato AU - Lastiri FL AUID- ORCID: 0000-0002-7120-9309 AD - Promotion and Education for Health and Food Research Group, Universidad La Salle Mexico, Benjamin Franklin 45, Colonia Condesa, Mexico City 06140, Mexico. FAU - Morales-Gonzalez, Jose A AU - Morales-Gonzalez JA AUID- ORCID: 0000-0002-5980-0980 AD - Laboratorio de Medicina de Conservacion, Escuela Superior de Medicina del Instituto Politecnico Nacional, Plan de San Luis y Diaz Miron s/n, Mexico City 11340, Mexico. FAU - Pinto-Almazan, Rodolfo AU - Pinto-Almazan R AUID- ORCID: 0000-0002-5210-5395 AD - Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina del Instituto Politecnico Nacional, Plan de San Luis y Diaz Miron s/n, Mexico City 11340, Mexico. AD - Fundacion Vithas, Grupo Hospitalario Vithas, 28043 Madrid, Spain. FAU - Vergara-Castaneda, Arely AU - Vergara-Castaneda A AUID- ORCID: 0000-0002-9366-3211 AD - Promotion and Education for Health and Food Research Group, Universidad La Salle Mexico, Benjamin Franklin 45, Colonia Condesa, Mexico City 06140, Mexico. LA - eng GR - Q097/13/Universidad La Salle/ PT - Journal Article DEP - 20251211 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12732249 OTO - NOTNLM OT - cardiovascular risk factors OT - chronic diseases OT - eating behaviors OT - lipid profile OT - school-aged children COIS- The authors declare no conflicts of interest. EDAT- 2025/12/30 07:41 MHDA- 2025/12/30 07:42 PMCR- 2025/12/11 CRDT- 2025/12/30 01:40 PHST- 2025/11/01 00:00 [received] PHST- 2025/12/05 00:00 [revised] PHST- 2025/12/09 00:00 [accepted] PHST- 2025/12/30 07:42 [medline] PHST- 2025/12/30 07:41 [pubmed] PHST- 2025/12/30 01:40 [entrez] PHST- 2025/12/11 00:00 [pmc-release] AID - children12121686 [pii] AID - children-12-01686 [pii] AID - 10.3390/children12121686 [doi] PST - epublish SO - Children (Basel). 2025 Dec 11;12(12):1686. doi: 10.3390/children12121686. PMID- 41462786 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251230 LR - 20260102 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 12 DP - 2025 Dec 3 TI - Evaluating an Eight-Week Therapeutic Swimming Program in Children with Autism Spectrum Disorder: A Mixed-Methods Study from Romania. LID - 10.3390/children12121646 [doi] LID - 1646 AB - Background/Objectives: In Romania, therapeutic program programs for children with autism spectrum disorder (ASD) focus mainly on behavioral and educational approaches, with limited integration of adapted physical activity (APA). Therapeutic swimming may provide complementary benefits, addressing both physical and psychosocial challenges. This study explored parent-perceived changes across an adapted therapeutic swimming program, following ABA therapy, on the well-being, learning, attention, physical activity, and social functioning of children with ASD. A custom-developed parent-report tool (PPQ-Autism-Swim) was used to measure perceived changes across key developmental domains. Methods: Thirty-nine children with ASD were recruited, of whom 36 completed the full 8-week swimming intervention. Parent-report questionnaires, developed by behavioral therapists under the supervision of a clinical psychologist, were administered at three time points: 8 weeks before swimming (T - 8), immediately before swimming after Applied Behaviour Analysis (ABA) therapy (T0), and 8 weeks after swimming (T + 8). The questionnaire assessed five subscales: general well-being, physical activity and energy, attention and focus, learning and cognitive progress, and self-confidence and social behaviors. Data were analyzed using descriptive statistics, repeated-measures ANOVA, and thematic analysis of qualitative parental feedback. ABA therapy served as a behavioral baseline, allowing comparison with subsequent gains from swimming. Results: Parents reported higher scores across time points, suggesting perceived changes in several domains. From T - 8 to T0, moderate gains followed ABA therapy, while from T0 to T + 8, therapeutic swimming was associated with improvements. At T + 8, 35 of 36 children showed measurable progress, particularly in physical activity regulation and self-confidence. Parental feedback emphasized calmer behavior, improved sleep, increased social interaction, and greater pride in new skills. Reliability testing indicated good to excellent internal consistency (Cronbach's alpha = 0.78-0.91). Conclusions: Therapeutic swimming appears to be an effective and motivating form of adapted physical education, complementing behavioral therapies and addressing multiple developmental challenges in children with ASD. FAU - Alecu, Stefan AU - Alecu S AUID- ORCID: 0009-0002-2252-4238 AD - Department of Physical Education and Special Motricity, Faculty of Physical Education and Mountain Sports, Transilvania University, 500068 Brasov, Romania. FAU - Onea, Gheorghe Adrian AU - Onea GA AUID- ORCID: 0009-0004-4441-9791 AD - Department of Physical Education and Special Motricity, Faculty of Physical Education and Mountain Sports, Transilvania University, 500068 Brasov, Romania. LA - eng PT - Journal Article DEP - 20251203 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12732067 OTO - NOTNLM OT - Romanian OT - adapted physical activity OT - aquatic therapy OT - autism spectrum disorder OT - child development OT - parental perception OT - therapeutic swimming COIS- The authors declare no conflicts of interest. EDAT- 2025/12/30 07:40 MHDA- 2025/12/30 07:41 PMCR- 2025/12/03 CRDT- 2025/12/30 01:39 PHST- 2025/10/22 00:00 [received] PHST- 2025/11/23 00:00 [revised] PHST- 2025/12/02 00:00 [accepted] PHST- 2025/12/30 07:41 [medline] PHST- 2025/12/30 07:40 [pubmed] PHST- 2025/12/30 01:39 [entrez] PHST- 2025/12/03 00:00 [pmc-release] AID - children12121646 [pii] AID - children-12-01646 [pii] AID - 10.3390/children12121646 [doi] PST - epublish SO - Children (Basel). 2025 Dec 3;12(12):1646. doi: 10.3390/children12121646. PMID- 41462770 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251230 LR - 20260102 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 12 DP - 2025 Dec 1 TI - Mindful Parenting and Picky Eating Behaviors in Early Childhood: Parental Dietary Competence as a Mediator. LID - 10.3390/children12121629 [doi] LID - 1629 AB - Background: Picky eating behaviors among children challenge nutritional intake and healthy development and place considerable stress on parents. Parenting approaches play a critical role in shaping young children's dietary behaviors. Mindful parenting, which refers to parents responding to their child's needs with awareness, acceptance, attention, and mindful discipline, has gained increasing attention. Parental dietary competence may determine whether mindful parenting effectively discourages picky eating behavior in children. Objectives: This study explored whether mindful parenting and parental dietary competence are associated with picky eating behaviors in young children. The mediating role of parental dietary competence in this association was also investigated. Methods: A total of 412 parents of children enrolled in six preschools across six administrative districts in New Taipei City, Taipei City, and Taoyuan City, Taiwan, were invited and recruited. Data were collected using three validated parent-reported instruments, including a mindful parenting scale, parental dietary competence scale, and children's picky eating behaviors scale. Results: Mindful parenting influenced children's picky eating behaviors through the full mediation of parental dietary competence. The identification of parental dietary competence as a mediator underscores the need for early preventive interventions and parenting education that integrate parental mindfulness and dietary competence to foster healthy eating habits from the outset of early childhood. Conclusions: Practical recommendations and future research directions are provided regarding mindful parenting, parental dietary competence, and picky eating behaviors in young children. FAU - Chen, Jo-Lin AU - Chen JL AD - Child and Family Studies, Fu Jen Catholic University, New Taipei City 242062, Taiwan. FAU - Chen, Su-Ping AU - Chen SP AD - Department of Living Services Industry, Tainan University of Technology, Tainan City 71002, Taiwan. FAU - Doong, Jia-Yau AU - Doong JY AUID- ORCID: 0000-0003-0365-3915 AD - Nutritional Science Studies, Fu Jen Catholic University, New Taipei City 242062, Taiwan. FAU - Huang, Shou-Chi AU - Huang SC AUID- ORCID: 0009-0001-9540-5283 AD - Child and Family Studies, Fu Jen Catholic University, New Taipei City 242062, Taiwan. LA - eng PT - Journal Article DEP - 20251201 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12731706 OTO - NOTNLM OT - early childhood OT - healthy eating habits OT - mindful parenting OT - parental dietary competence OT - parenting approaches OT - picky eating behaviors COIS- The authors declare no conflicts of interest. EDAT- 2025/12/30 07:40 MHDA- 2025/12/30 07:41 PMCR- 2025/12/01 CRDT- 2025/12/30 01:39 PHST- 2025/10/10 00:00 [received] PHST- 2025/11/14 00:00 [revised] PHST- 2025/11/25 00:00 [accepted] PHST- 2025/12/30 07:41 [medline] PHST- 2025/12/30 07:40 [pubmed] PHST- 2025/12/30 01:39 [entrez] PHST- 2025/12/01 00:00 [pmc-release] AID - children12121629 [pii] AID - children-12-01629 [pii] AID - 10.3390/children12121629 [doi] PST - epublish SO - Children (Basel). 2025 Dec 1;12(12):1629. doi: 10.3390/children12121629. PMID- 41462756 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251230 LR - 20260102 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 12 DP - 2025 Nov 27 TI - Computing and Evaluating Relationships Between Equal and Differential Factor Weighting for Fundamental Movement Skills and Physical Activity with Guided Active Play During Childhood. LID - 10.3390/children12121615 [doi] LID - 1615 AB - Background/Objectives: The Test of Gross Motor Development (TGMD-2) totals assume equal weighting of the 12 locomotor (LOC) and object control (OC) skills, yet validation studies indicate differential contributions. The study compared equal- and differential-weighted scores for LOC and OC skills, with three fitness and two physical activity (PA) outputs during guided active play (GAP). Methods: Children's (n = 82; 7.6 +/- 1.5 years) TGMD-2 LOC and OC differential factor weights were estimated with Exploratory Factor Analysis (EFA) and compared to equal weights with multiple linear regression (two, five, and eight predictors) and Chi-square analyses. Predictor variables included fitness, BMI, sex, age stages, and PA assessed by energy expenditure (PAEE) and intensity (MVPA) estimated using accelerometry during 1 h GAP. Results: EFA supported a two-factor structure (variance explained = 51.1%) with >/=0.500 loadings for 9/12 skills. Differential- and equal-weighted LOC and OC scores showed varied contributions from individual skills. Multiple linear regression analysis showed similar explained variances (R(2)) of 53% (PAEE), 40% (MVPA), 31% (OC), and 14% (LOC) for equal or differential scores with eight predictors. Although beta coefficients varied, going from two, five, and eight predictors, the impact of equal and differential weights was comparable. Chi-square analysis indicated high OC associated with MVPA (X(2) (4) = 9.42, p /=2.5). CONCLUSIONS: A proinflammatory diet is associated with lower fecundability in multiethnic Asian women without known infertility. Further studies are needed to clarify the role of insulin resistance in this relationship. CI - Copyright (c) 2025 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Loh, Jason AU - Loh J AD - Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore. FAU - Yu, Guoqi AU - Yu G AD - Global Centre for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. FAU - Colega, Marjorelee T AU - Colega MT AD - Institute for Human Development and Potential, Agency for Science, Technology and Research, Singapore. FAU - Tan, Karen AU - Tan K AD - Institute for Human Development and Potential, Agency for Science, Technology and Research, Singapore. FAU - Chong, Yap Seng AU - Chong YS AD - Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Institute for Human Development and Potential, Agency for Science, Technology and Research, Singapore. FAU - Godfrey, Keith M AU - Godfrey KM AD - MRC Lifecourse Epidemiology Centre & NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom. FAU - Chan, Jerry Kok Yen AU - Chan JKY AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore; Duke-NUS Medical School, Singapore; SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore. FAU - Chan, Shiao-Yng AU - Chan SY AD - Institute for Human Development and Potential, Agency for Science, Technology and Research, Singapore; Department of Obstetrics & Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore. FAU - Eriksson, Johan G AU - Eriksson JG AD - Institute for Human Development and Potential, Agency for Science, Technology and Research, Singapore; Department of Obstetrics & Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, & Folkhalsan Research Center, University of Helsinki, Helsinki, Finland. FAU - Chong, Mary Ff AU - Chong MF AD - Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore. FAU - Loy, See Ling AU - Loy SL AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore; Duke-NUS Medical School, Singapore; SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore. FAU - Lai, Jun S AU - Lai JS AD - Institute for Human Development and Potential, Agency for Science, Technology and Research, Singapore. Electronic address: lai_jun_shi@sics.a-star.edu.sg. LA - eng GR - MC_UU_12011/4/MRC_/Medical Research Council/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251227 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 RN - 9007-41-4 (C-Reactive Protein) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Adult MH - *Diet/adverse effects MH - Singapore MH - *Inflammation MH - C-Reactive Protein/metabolism MH - *Fertility MH - Asian People MH - Cohort Studies MH - Pregnancy MH - Biomarkers/blood MH - Insulin Resistance OTO - NOTNLM OT - empirical dietary inflammatory pattern OT - fecundability OT - fertility OT - time-to-pregnancy OT - women COIS- Conflict of interest YSC reports financial support was provided by National Medical Research Council. KMG reports financial support was provided by UK Research and Innovation Medical Research Council. KMG reports financial support was provided by National Institute for Health Research. KMG reports financial support was provided by European Union. KMG reports a relationship with EpiGen Consortium that includes: speaking and lecture fees and travel reimbursement. YSC reports a relationship with EpiGen Consortium that includes: speaking and lecture fees and travel reimbursement. All other authors report no conflicts of interest. EDAT- 2025/12/30 00:30 MHDA- 2026/02/17 00:53 CRDT- 2025/12/29 19:27 PHST- 2025/08/04 00:00 [received] PHST- 2025/12/14 00:00 [revised] PHST- 2025/12/22 00:00 [accepted] PHST- 2026/02/17 00:53 [medline] PHST- 2025/12/30 00:30 [pubmed] PHST- 2025/12/29 19:27 [entrez] AID - S0022-3166(25)00789-8 [pii] AID - 10.1016/j.tjnut.2025.101283 [doi] PST - ppublish SO - J Nutr. 2026 Feb;156(2):101283. doi: 10.1016/j.tjnut.2025.101283. Epub 2025 Dec 27. PMID- 41460020 OWN - NLM STAT- MEDLINE DCOM- 20260209 LR - 20260610 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2025 Dec 29 TI - The initial development and validation of a child-oriented food literacy questionnaire. PG - e26 LID - 10.1017/S1368980025101651 [doi] LID - e26 AB - OBJECTIVE: The Dutch Children's Food Literacy Questionnaire (DCFLQ) was developed and validated to assess food literacy among children aged 8-12 years. The DCFLQ is structured around farm-to-fork principles, including questions on food production, distribution, consumption, waste, and sustainability. DESIGN: After initial item pool creation, the DCFLQ was developed in collaboration with experts and children. The validation process included assessments of reliability and construct validity, as well as a test-retest evaluation in a subgroup of children. SETTING: The expert panel consisted of domain-related researchers, a pedagogue, a paediatrician, dietitians and a primary school teacher. Children were recruited via primary schools and a sports club. PARTICIPANTS: A total of eleven experts and twenty-seven children participated in the development process; 608 children participated in the validation process. RESULTS: The final questionnaire comprised twenty-nine questions and demonstrated good internal consistency (Cronbach's alpha = 0.80) and test-retest reliability (ICC = 0.81). DCFLQ scores positively correlated with age, indicating that food literacy is higher in older children. CONCLUSIONS: The DCFLQ is a valuable tool for assessing the effectiveness of nutrition intervention programmes and monitoring Dutch children's food literacy over time. International expert consensus on developing food literacy instruments is needed, as diversity in assessment tools impedes cross-cultural comparisons. FAU - van Lier, Ilse AU - van Lier I AUID- ORCID: 0000-0001-8381-1252 AD - Chair Group Youth, Food & Health, https://ror.org/02jz4aj89Maastricht University Campus Venlo, Venlo, the Netherlands. FAU - van Belkom, Britt AU - van Belkom B AD - Chair Group Youth, Food & Health, https://ror.org/02jz4aj89Maastricht University Campus Venlo, Venlo, the Netherlands. FAU - van Mil, Edgar AU - van Mil E AD - Chair Group Youth, Food & Health, https://ror.org/02jz4aj89Maastricht University Campus Venlo, Venlo, the Netherlands. AD - Department of Paediatrics, Children's Lifestyle Medicine Centre, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands. FAU - Havermans, Remco AU - Havermans R AUID- ORCID: 0000-0001-5832-8357 AD - Chair Group Youth, Food & Health, https://ror.org/02jz4aj89Maastricht University Campus Venlo, Venlo, the Netherlands. AD - Laboratory of Behavioural Gastronomy, Maastricht University Campus Venlo, Venlo, the Netherlands. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20251229 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Child MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Netherlands MH - Male MH - Female MH - *Health Literacy MH - *Diet PMC - PMC12895494 OTO - NOTNLM OT - Children OT - Farm-to-fork OT - Food literacy OT - Instrument development OT - Questionnaire COIS- There are no conflicts of interest. EDAT- 2025/12/29 13:02 MHDA- 2026/02/09 06:30 PMCR- 2025/12/29 CRDT- 2025/12/29 08:43 PHST- 2026/02/09 06:30 [medline] PHST- 2025/12/29 13:02 [pubmed] PHST- 2025/12/29 08:43 [entrez] PHST- 2025/12/29 00:00 [pmc-release] AID - S1368980025101651 [pii] AID - 10.1017/S1368980025101651 [doi] PST - epublish SO - Public Health Nutr. 2025 Dec 29;29(1):e26. doi: 10.1017/S1368980025101651. PMID- 41458428 OWN - NLM STAT- MEDLINE DCOM- 20251229 LR - 20251231 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Development and validation of a predictive model for weight loss psychological distress in obese patients: a cross-sectional study. PG - 1700100 LID - 10.3389/fpubh.2025.1700100 [doi] LID - 1700100 AB - BACKGROUND: Obese patients are more likely to experience psychological distress symptoms, such as low self-esteem, anxiety and depression. Approximately 18-55% of obese patients will encounter problems such as abdominal distension, purple skin lines and facial acne due to changes in their body shape and appearance. Establishing a predictive model for psychological distress in obese patients during the weight loss process, early identification of high-risk groups, and the adoption of proactive intervention measures can help reduce the incidence of psychological distress. AIMS: Explore the risk factors for psychological distress among middle-aged and young obese patients, and construct and validate a risk prediction model for psychological distress. METHODS: The study was a cross-sectional survey study, From January to June in 2025, a total of 357 obese patients were selected from 22 tertiary hospitals in Jiangxi Province, China. The model was constructed by univariate and logistic regression analyses. They were divided into the group with significant psychological distress (K10 >/= 16 points) and the group without significant psychological distress (K10 < 16 points). R4.2.3 Statistical software was used to construct a risk prediction model for psychological distress in obese patients regarding weight loss. The discriminative ability of the model was evaluated by the receiver operating characteristic (ROC) curve, the accuracy of the predictive model was evaluated by the Hosmer-Lemeshow test and calibration curves, and the clinical utility was assessed using decision curve analysis (DCA). RESULTS: Two hundred fifty-five patients were in the training set and 102 were in the validation set. Through logistics regression analysis, the following seven predictive factors were obtained: age (youth), gender (female), history of chronic diseases, high BMI, weight loss method (diet and exercise for weight loss), perceived social support, and general self-efficacy. The area under the ROC curve of the model was 0.852 (95%CI, 0.806 ~ 0.897). The sensitivity and specificity were 0.804 and 0.729. The maximum Youden index was 0.520, and the best cut-off value was 0.396. The Hosmer-Lemeshow test showed that chi (2) = 4.560 and p = 0.803. The internal and external validation results showed that the area under the ROC curve was 0.858 and 0.833 respectively, and the Hosmer-Lemeshow test results showed that the chi (2) was 0.664 and 0.765, respectively. The decision curve analysis shows that obese patients have better clinical benefits. CONCLUSION: This study developed a predictive model for weight loss psychological distress in obese patients, which has strong predictive performance and has been verified by internal and external cohorts. It was helpful for the early detection of high-risk groups for weight loss psychological distress. CI - Copyright (c) 2025 Cheng, Liu, Li, Tang and Huang. FAU - Cheng, Zhiqiang AU - Cheng Z AD - Department of Health Management Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. FAU - Liu, Meiling AU - Liu M AD - Department of Health Management Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. FAU - Li, Xiaxin AU - Li X AD - Department of Nursing, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China. FAU - Tang, Jiazhen AU - Tang J AD - Department of Health Management Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. FAU - Huang, Caihong AU - Huang C AD - Department of Anesthesiology and Surgery, The First Affiliated Hospital of Gan Nan Medical University, Jiangxi, Ganzhou, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20251201 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Male MH - *Obesity/psychology MH - Middle Aged MH - Adult MH - *Weight Loss MH - *Psychological Distress MH - China MH - Risk Factors MH - Surveys and Questionnaires MH - *Stress, Psychological/epidemiology PMC - PMC12741267 OTO - NOTNLM OT - nursing care OT - obesity OT - predictive model OT - psychological distress OT - risk factors COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/29 07:08 MHDA- 2025/12/29 07:09 PMCR- 2025/12/01 CRDT- 2025/12/29 05:10 PHST- 2025/09/06 00:00 [received] PHST- 2025/11/11 00:00 [revised] PHST- 2025/11/12 00:00 [accepted] PHST- 2025/12/29 07:09 [medline] PHST- 2025/12/29 07:08 [pubmed] PHST- 2025/12/29 05:10 [entrez] PHST- 2025/12/01 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1700100 [doi] PST - epublish SO - Front Public Health. 2025 Dec 1;13:1700100. doi: 10.3389/fpubh.2025.1700100. eCollection 2025. PMID- 41458372 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251229 LR - 20260926 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 1 DP - 2026 Jan TI - Ultrasound Assessment of Diaphragmatic Function in Children With Cerebral Palsy: A Cross-Sectional Observational Case-Control Study. PG - e71644 LID - 10.1002/hsr2.71644 [doi] LID - e71644 AB - BACKGROUND AND AIMS: Children with cerebral palsy (CP) are vulnerable to respiratory infections and chronic airway inflammation, which leads to diminished respiratory function. This decline is exacerbated by muscle tone abnormalities and reduced strength, worsening as CP progresses. Traditional lung function tests are often impractical for those with severe cognitive and motor impairments. Diaphragm evaluation through ultrasound imaging emerges as a non-invasive, easy-to-apply technique for assessing respiratory function in CP children. This study aimed to evaluate diaphragm function in CP and typically developing (TD) children using ultrasound, focusing on diaphragm thickness and excursion parameters. The study also explored factors influencing respiratory function, particularly the number of lower respiratory tract infections (LRTI). METHODS: The study included 10 CP (11.2; range 4-17 years) and 12 TD children (8.9 years; range 4-13 years). M-mode ultrasound assessed diaphragm thickness, thickening fraction (TF), and inspiratory slope (IS). Additionally, data on demographics, anthropometrics, medical history, and physical examination were collected. RESULTS: The intra-operator reliability for diaphragm ultrasound measurements showed good to excellent consistency (over 0.86). Significant differences were found between CP and TD children; CP children exhibited lower excursion and IS, with a non-significant trend towards reduced diaphragm thickness. LTRI were associated to decreased excursion and IS, and increased TF in CP children. CONCLUSIONS: Diaphragmatic ultrasound is a non-invasive, reproducible tool for assessing respiratory function in both CP and TD children, even in cases of severe cognitive and motor impairment. It effectively identifies diaphragm dysfunction associated with LRTI. CI - (c) 2025 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Casellas-Vidal, Dolors AU - Casellas-Vidal D AUID- ORCID: 0000-0001-9560-6758 AD - Servei de Pediatria Hospital Universitari Doctor Josep Trueta Girona Spain. AD - Neurodevelopmental Group (Girona Biomedical Research Institute)-IDIBGI, Institute of Health Assistance (IAS) Parc Hospitalari Marti i Julia Girona Spain. FAU - Osiniri, Ines AU - Osiniri I AD - Servei de Pediatria Clinica Bofill Girona Spain. FAU - Font-Llado, Raquel AU - Font-Llado R AUID- ORCID: 0000-0002-2282-2756 AD - University School of Health and Sport (EUSES) University of Girona Girona Spain. AD - Research Group of Culture and Education, Institute of Educational Research University of Girona Girona Spain. FAU - Camos-Carreras, Maria AU - Camos-Carreras M AD - Servei de Pediatria Hospital Universitari Doctor Josep Trueta Girona Spain. AD - Neurodevelopmental Group (Girona Biomedical Research Institute)-IDIBGI, Institute of Health Assistance (IAS) Parc Hospitalari Marti i Julia Girona Spain. FAU - Ruiz-Eizmendi, Aintzane AU - Ruiz-Eizmendi A AD - Servei de Rehabilitacio Hospital Universitari Doctor Josep Trueta Girona Spain. FAU - Serrano-Ferrer, Juan AU - Serrano-Ferrer J AD - University School of Health and Sport (EUSES) University of Girona Girona Spain. FAU - Casellas, Joaquim AU - Casellas J AUID- ORCID: 0000-0002-4982-3556 AD - Departament de Ciencia Animal i dels Aliments Universitat Autonoma de Barcelona Bellaterra Spain. FAU - Lopez-Bermejo, Abel AU - Lopez-Bermejo A AUID- ORCID: 0000-0002-5828-8911 AD - Servei de Pediatria Hospital Universitari Doctor Josep Trueta Girona Spain. AD - Pediatric Endocrinology Group Girona Biomedical Research Institute (IDIBGI) Salt Spain. AD - Department of Medical Sciences, School of Medicine University of Girona Girona Spain. FAU - Prats-Puig, Anna AU - Prats-Puig A AUID- ORCID: 0000-0002-5253-3808 AD - University School of Health and Sport (EUSES) University of Girona Girona Spain. AD - Research Group Health and Health Care, Nursing Department University of Girona Girona Spain. LA - eng PT - Journal Article DEP - 20251225 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC12741228 OTO - NOTNLM OT - cerebral palsy OT - diaphragm ultrasound OT - lower respiratory tract infection OT - respiratory function COIS- The authors declare no conflicts of interest. EDAT- 2025/12/29 07:08 MHDA- 2025/12/29 07:09 PMCR- 2025/12/25 CRDT- 2025/12/29 05:10 PHST- 2025/01/20 00:00 [received] PHST- 2025/05/20 00:00 [revised] PHST- 2025/12/02 00:00 [accepted] PHST- 2025/12/29 07:09 [medline] PHST- 2025/12/29 07:08 [pubmed] PHST- 2025/12/29 05:10 [entrez] PHST- 2025/12/25 00:00 [pmc-release] AID - HSR271644 [pii] AID - 10.1002/hsr2.71644 [doi] PST - epublish SO - Health Sci Rep. 2025 Dec 25;9(1):e71644. doi: 10.1002/hsr2.71644. eCollection 2026 Jan. PMID- 41457222 OWN - NLM STAT- MEDLINE DCOM- 20260207 LR - 20260604 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2025 Dec 28 TI - The association between accelerometer-measured physical activity and symptoms of depression and anxiety in children and adolescents: a systematic review and meta-analysis. PG - 96 LID - 10.1186/s12887-025-06420-y [doi] LID - 96 AB - BACKGROUND: Physical activity (PA) is associated with symptoms of depression and anxiety in children and adolescents. Using accelerometers to measure PA can provide more accurate and detailed data to investigate this relationship. However, no study has systematically reviewed and pooled the effects of accelerometer-measured PA on mental health. Therefore, this meta-analysis examined the association between accelerometer-measured PA and symptoms of depression and anxiety in children and adolescents and determined whether the strength of this relationship varied by accelerometery methodology. METHODS: A systematic review conducted up to May 2025 using the following databases: Medline, PsycINFO, Embase, Web of Science, and SPORTDiscus, following the PRISMA guidelines, and using terms relating to children, PA, depression/anxiety and observational design. Meta-analyses were performed separately for 12 studies with continuous outcomes (Partial r) and 7 studies with binary outcomes (Odds Ratio). Subgroup analysis tested the moderating effects of accelerometer data collection and processing methods (e.g., epoch length, wear location, valid days, valid hours). RESULTS: Thirty studies met the inclusion criteria (n = 15 cross-sectional, n = 15 prospective) including 40,334 youth aged 5-18 years. There was a small negative association of moderate-to-vigorous physical activity (MVPA) with depression (partial r = -0.17, 95%CI [-0.28, -0.06], p < 0.001) and anxiety (partial r = -0.21, 95%CI [-0.34, -0.09], p < 0.001). Total physical activity (TPA) (OR = 0.98, 95%CI [0.96,1.00], p = 0.05) and light intensity PA (OR = 0.95, 95%CI [0.92,0.98], p < 0.001) were associated with reduced risk of depression. The association between MVPA and depression appeared to vary by epoch length ( 15 s partial r = -0.08, 95% [-0.19, 0.03]; difference p = 0.02). Sensitivity and publication bias analyses supported the overall robustness and reliability of the associations between PA and depression or anxiety. CONCLUSIONS: This review highlights that while PA was associated with reduced depression and anxiety in youth, substantial methodological heterogeneity, particularly in accelerometer protocols, may influence effect sizes. Improved and standardised accelerometry methodologies and developed innovative PA metrics are needed to better assess these relationships. TRIAL REGISTRATION: The protocol for the present review was registered on PROSPERO (CRD42022320410) on 23rd March 2022. KEY POINTS: * This systematic review included 30 studies involving 40,334 children and adolescents aged 5-18 years and revealed substantial variability in accelerometer data collection and processing methods across studies, including 11 different device models, 4 wear locations, 6 epoch lengths, 4 intensity thresholds units, 5 valid day definitions, and 7 non-wear criteria, as well as 17 questionnaires used to assess depression and anxiety. * Meta-analysis results showed that moderate-to-vigorous, total, and light physical activity were associated with reduced depression and anxiety in youth, while epoch length and accelerometer wear location may affect the magnitude of this relationship. The findings remained consistent across sensitivity analyses, and no evidence of publication bias was detected. * Of the 30 studies assessed for risk of bias, 2 were rated as good quality, 22 as fair quality, and 6 as poor quality. The main quality problems were the lack of sample size justification, or insufficient reporting of uniform selection criteria. CI - (c) 2025. The Author(s). FAU - Wang, Lin AU - Wang L AD - Faculty of Health and Life Sciences, Public Health and Sport Sciences, University of Exeter, Room 33 Haighton Library, Heavitree Road, St Luke's Campus, Exeter, Devon, EX1 2LU, UK. lw679@exeter.ac.uk. FAU - Barker, Alan R AU - Barker AR AD - Faculty of Health and Life Sciences, Children's Health and Exercise Research Centre, Public Health and Sport Sciences, University of Exeter, Exeter, UK. FAU - Metcalf, Brad AU - Metcalf B AD - Faculty of Health and Life Sciences, Public Health and Sport Sciences, University of Exeter, Room 33 Haighton Library, Heavitree Road, St Luke's Campus, Exeter, Devon, EX1 2LU, UK. FAU - Liu, Yihao AU - Liu Y AD - Department of Social Psychiatry, West China Hospital, Sichuan University, Sichuan, 610041, Chengdu, China. FAU - Hillsdon, Melvyn AU - Hillsdon M AD - Faculty of Health and Life Sciences, Public Health and Sport Sciences, University of Exeter, Room 33 Haighton Library, Heavitree Road, St Luke's Campus, Exeter, Devon, EX1 2LU, UK. FAU - Price, Lisa AU - Price L AD - Faculty of Health and Life Sciences, Public Health and Sport Sciences, University of Exeter, Room 33 Haighton Library, Heavitree Road, St Luke's Campus, Exeter, Devon, EX1 2LU, UK. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20251228 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Child MH - Adolescent MH - *Accelerometry MH - *Exercise/psychology MH - *Depression MH - *Anxiety MH - Child, Preschool PMC - PMC12882467 OTO - NOTNLM OT - Accelerometery methodologies OT - Activity behaviours OT - Mental health OT - Young people COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/29 00:24 MHDA- 2026/02/07 06:33 PMCR- 2025/12/28 CRDT- 2025/12/28 23:13 PHST- 2025/08/07 00:00 [received] PHST- 2025/11/25 00:00 [accepted] PHST- 2026/02/07 06:33 [medline] PHST- 2025/12/29 00:24 [pubmed] PHST- 2025/12/28 23:13 [entrez] PHST- 2025/12/28 00:00 [pmc-release] AID - 10.1186/s12887-025-06420-y [pii] AID - 6420 [pii] AID - 10.1186/s12887-025-06420-y [doi] PST - epublish SO - BMC Pediatr. 2025 Dec 28;26(1):96. doi: 10.1186/s12887-025-06420-y. PMID- 41456969 OWN - NLM STAT- MEDLINE DCOM- 20260211 LR - 20260518 IS - 1871-403X (Print) IS - 1871-403X (Linking) VI - 20 IP - 1 DP - 2026 Jan-Feb TI - Children's experience of screening and evaluation for MASLD in overweight and obesity. PG - 76-79 LID - S1871-403X(25)00155-3 [pii] LID - 10.1016/j.orcp.2025.12.010 [doi] AB - OBJECTIVE: This study evaluates self-reported discomfort in children undergoing screening and evaluation for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) that includes blood sampling and vibration-controlled transient elastography (VCTE) or shear-wave elastography (SWE). METHODS: In this cross-sectional multicenter cohort study, children with overweight or obesity, referred for MASLD evaluation after elevated ALT, were included. Children subsequently underwent anthropometric measurements, blood sampling, VCTE, and SWE during an outpatient visit. Discomfort was assessed using the validated "Discomfort in Research with Children" (DISCO-RC) questionnaire on a 5-point Likert scale. RESULTS: 118 children (mean age 13 years) were included. Discomfort related to MASLD screening was low, with median domain scores of 1-2 before the MASLD evaluation visit and 1 after. Prior to the visit, 76-82 % reported "no" to "slight" discomfort (score 1-2) across domains; during the visit, this was 91-95 %. Median procedural discomfort per domain was 1 for both VCTE and SWE, though cumulative discomfort (6 domains) was greater for VCTE than SWE (8 [IQR 6,9] versus 7 [IQR 6,8] p < 0.001). CONCLUSIONS: Screening and subsequent evaluation for MASLD, including VCTE or SWE for liver fibrosis assessment, is associated with minimal discomfort and is highly acceptable to children, supporting this screening strategy in pediatric clinical practice. CI - Copyright (c) 2025 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved. FAU - Stroes, Anne-Sophie R AU - Stroes AR AD - Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam, the Netherlands; Amsterdam Reproduction and Development Research Institute, Amsterdam, the Netherlands. Electronic address: a.r.stroes@amsterdamumc.nl. FAU - Draijer, Laura AU - Draijer L AD - Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands. FAU - van Oers, Hedy A AU - van Oers HA AD - Department of Child and Adolescent Psychiatry and Psychosocial Care, Emma Children's Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands. FAU - Chegary, Malika AU - Chegary M AD - Department of Pediatrics, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands. FAU - Kreier, Felix AU - Kreier F AD - Department of Pediatrics, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands. FAU - van Os, Erim AU - van Os E AD - Department of Pediatrics, Rode Kruis Ziekenhuis, Beverwijk, the Netherlands. FAU - Goede, Joery AU - Goede J AD - Department of Pediatrics, Spaarne Gasthuis, Haarlem, the Netherlands. FAU - Boonstra, Venje AU - Boonstra V AD - Department of Pediatrics, BovenIJ Ziekenhuis, Amsterdam, the Netherlands. FAU - Westerbeek, Ilse AU - Westerbeek I AD - Department of Pediatrics, Amstelland Ziekenhuis, Amsterdam, the Netherlands. FAU - Bouma, Saskia AU - Bouma S AD - De Kinderartsenpraktijk, Amsterdam, the Netherlands. FAU - Kusters, D Meeike AU - Kusters DM AD - Department of Pediatrics, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands. FAU - Roelants, Roosje AU - Roelants R AD - Department of Pediatrics, Flevoziekenhuis, Almere, the Netherlands. FAU - Beuers, Ulrich AU - Beuers U AD - Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam, the Netherlands; Department of Gastroenterology and Hepatology, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, the Netherlands. FAU - Holleboom, Adriaan G AU - Holleboom AG AD - Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam, the Netherlands; Department of Vascular Medicine, Amsterdam University Medical Centre, Amsterdam, the Netherlands. FAU - Benninga, Marc A AU - Benninga MA AD - Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam, the Netherlands; Amsterdam Reproduction and Development Research Institute, Amsterdam, the Netherlands. FAU - Koot, Bart G P AU - Koot BGP AD - Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam, the Netherlands; Amsterdam Reproduction and Development Research Institute, Amsterdam, the Netherlands. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20251227 PL - Netherlands TA - Obes Res Clin Pract JT - Obesity research & clinical practice JID - 101303911 SB - IM MH - Humans MH - Female MH - Male MH - Cross-Sectional Studies MH - Child MH - Adolescent MH - *Pediatric Obesity/complications MH - Elasticity Imaging Techniques MH - *Mass Screening MH - *Overweight/complications MH - *Fatty Liver/diagnosis/etiology MH - Self Report MH - Cohort Studies OTO - NOTNLM OT - Children OT - Discomfort Assessment OT - Metabolic dysfunction-Associated Steatotic Liver Disease OT - Patient Experience OT - Patient-Reported Outcomes COIS- Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Anne-Sophie Stroes reports financial support was provided by Forwis(h)dom foundation. Anne-Sophie Stroes reports financial support was provided by Virtutis Opus foundation. Anne-Sophie Stroes reports financial support was provided by Jean Louis Bernardi foundation. Anne-Sophie Stroes reports financial support was provided by Louise Vehmeijer foundation. Bart Koot reports a relationship with Boehringer Ingelheim and Inventiva that includes: consulting or advisory. Ulrich Beuers reports a relationship with Abacus, Amgen, Behring, Ipsen, Mirum, Ono that includes: consulting or advisory. Ulrich Beuers reports a relationship with Abacus, Amgen, GSK, Ipsen that includes: speaking and lecture fees. Adriaan Holleboom reports a relationship with Novo Nordisk, Inventiva and Echosens that includes: consulting or advisory. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/12/29 00:24 MHDA- 2026/02/12 00:47 CRDT- 2025/12/28 21:56 PHST- 2025/12/12 00:00 [received] PHST- 2025/12/20 00:00 [accepted] PHST- 2026/02/12 00:47 [medline] PHST- 2025/12/29 00:24 [pubmed] PHST- 2025/12/28 21:56 [entrez] AID - S1871-403X(25)00155-3 [pii] AID - 10.1016/j.orcp.2025.12.010 [doi] PST - ppublish SO - Obes Res Clin Pract. 2026 Jan-Feb;20(1):76-79. doi: 10.1016/j.orcp.2025.12.010. Epub 2025 Dec 27. PMID- 41456246 OWN - NLM STAT- MEDLINE DCOM- 20260916 LR - 20261008 IS - 1573-3572 (Electronic) IS - 1068-9583 (Linking) VI - 33 IP - 3 DP - 2026 Sep TI - Understanding Family Burden Associated with Pediatric Food Allergy: Contributions of Child Neophobia and Maternal Personality Traits. PG - 492-501 LID - 10.1007/s10880-025-10118-9 [doi] AB - Food allergy (FA) is a chronic condition that can markedly affect family quality of life (QoL). Children's food neophobia (FN) may increase dietary management difficulties and parental stress, while maternal personality traits can shape family adjustment. This study examined the associations between maternal neuroticism, child FN, and the perceived impact of FA on family QoL, also considering the influence of child age. Sixty-three Portuguese mothers of children with physician-diagnosed FA completed a sociodemographic and clinical questionnaire and validated self-report measures: the Food Neophobia Scale for Children, the NEO Five-Factor Inventory, and the Food Allergy Quality of Life Questionnaire - Parent Form (FAQLQ-PF). Preliminary correlations guided predictor selection, followed by multiple linear regression models (enter method) for each FAQLQ-PF subscale: Emotional Impact, Food Anxiety, and Dietary/Social Limitations. Higher maternal neuroticism, greater child FN, and older child age were significantly associated with a greater perceived impact of FA on family QoL. The models explained 35.5% of the variance in Emotional Impact, F (3, 58) = 12.19, p < .001; 35.5% in Food Anxiety, F (3, 58) = 12.19, p < .001; and 32.9% in Dietary/Social Limitations, F (3, 56) = 10.66, p < .001. These findings underscore the need to integrate psychological screening and tailored psychosocial support into allergy care, addressing both maternal emotional traits and child eating behaviors to promote adaptive family functioning. CI - (c) 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Domingues, Mariana AU - Domingues M AD - CINTESIS.UPT@RISE-HEALTH, Universidade Portucalense, Porto, Portugal. marianavidomingues@gmail.com. FAU - Monteiro, Andreia AU - Monteiro A AD - Department of Psychology and Education, Universidade Portucalense, Porto, Portugal. FAU - Conde, Ana AU - Conde A AD - CINTESIS.UPT@RISE-HEALTH, Universidade Portucalense, Porto, Portugal. anac@upt.pt. FAU - Coimbra, Alice AU - Coimbra A AD - Allergy and Clinical Immunology Department, ULS Sao Joao, Porto, Portugal. FAU - Araujo, Maria AU - Araujo M AD - Department of Psychology and Education, Universidade Portucalense, Porto, Portugal. maraujo@upt.pt. LA - eng PT - Journal Article DEP - 20251228 PL - United States TA - J Clin Psychol Med Settings JT - Journal of clinical psychology in medical settings JID - 9435680 SB - IM MH - Humans MH - Female MH - Child MH - *Food Hypersensitivity/psychology MH - *Mothers/psychology MH - Adult MH - *Neuroticism MH - *Quality of Life/psychology MH - Male MH - Child, Preschool MH - Portugal MH - *Personality MH - *Cost of Illness MH - Adolescent MH - Surveys and Questionnaires OTO - NOTNLM OT - Chronic illness adaptation OT - Family impact OT - Food allergy OT - Food neophobia OT - Maternal personality COIS- Declarations. Conflict of interest: The authors declare no competing interests. EDAT- 2025/12/28 14:53 MHDA- 2026/09/16 17:36 CRDT- 2025/12/28 11:04 PHST- 2025/07/11 00:00 [received] PHST- 2025/12/10 00:00 [accepted] PHST- 2026/09/16 17:36 [medline] PHST- 2025/12/28 14:53 [pubmed] PHST- 2025/12/28 11:04 [entrez] AID - 10.1007/s10880-025-10118-9 [pii] AID - 10.1007/s10880-025-10118-9 [doi] PST - ppublish SO - J Clin Psychol Med Settings. 2026 Sep;33(3):492-501. doi: 10.1007/s10880-025-10118-9. Epub 2025 Dec 28. PMID- 41455930 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2025 Dec 27 TI - Maternal Endocrine and Metabolic Health and Outcomes (MEMO): a prospective cohort study of gestational diabetes mellitus and subclinical hypothyroidism in China. PG - 147 LID - 10.1186/s12884-025-08294-5 [doi] LID - 147 AB - BACKGROUND: In recent years, more and more evidence has confirmed the "Developmental Origins of Health and Disease (DOHaD)" hypothesis, which states that adverse environments in early life can increase the risk of long-term metabolic diseases such as obesity and diabetes. Gestational diabetes mellitus (GDM) and subclinical hypothyroidism (SCH) during pregnancy are the most common endocrine diseases, which directly interfere with the intrauterine development environment of the fetus and thus are ideal research entry points for validating and extending the DOHaD theory. OBJECTIVE: This study aims to deeply explore the early impact of maternal endocrine disorders during pregnancy (with a focus on GDM and SCH) on the healthy development of the fetus, using key indicators such as birth weight as measures of early health outcomes. The research objectives include: 1) To Identify potential biomarkers that can be used for early prediction of GDM and SCH; 2) To observe the extent to which GDM and SCH affect the pregnancy outcome. METHODS: This will be a prospective cohort study involving 300 pregnant women. In addition to collecting general demographic information and clinical data of pregnant women, we also collect peripheral blood, urine, and fecal samples from pregnant women during the early, middle, and late stages of pregnancy. We also collect placental and umbilical cord blood samples during delivery. We conduct multi-omics analysis on the samples to comprehensively screen for differentially expressed molecules related to gestational endocrine diseases (GDM and SCH) and adverse outcomes. The main evaluation indicators are the birth weight of the offspring, including low birth weight, macrosomia, small for gestational age, and large for gestational age. The secondary outcome indicators include the following: 1) neonatal-related outcomes that include intrauterine growth restriction (IUGR), intrauterine fetal death (IUFD), preterm birth, low Apgar score, admission to the neonatal intensive care unit (NICU); and 2) maternal pregnancy outcomes that include gestational hypertension, preeclampsia, eclampsia, anemia, spontaneous abortion, type of delivery (vaginal, assisted vaginal delivery or cesarean section) and other complications. CONCLUSIONS: This study aims to establish a prospective Chinese pregnant cohort to investigate the effects of GDM and SCH on pregnancy outcomes. On this basis, this study will utilize multi-time-point collected biological samples and combine multi-omics technologies to identify high-risk phenotypic characteristics related to GDM and SCH, with the aim of achieving early identification, and hopefully, intervention in the future, thereby reducing adverse pregnancy outcomes and the risk of long-term chronic diseases in the offspring. TRIAL REGISTRATION: ClinicalTrials.gov ID: NCT05952739. Study Registration Dates: July 19, 2023. FAU - Zeng, Yuan AU - Zeng Y AD - Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. FAU - Yu, Jie AU - Yu J AD - Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. FAU - Ren, Yaolin AU - Ren Y AD - Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. FAU - Ren, Jing AU - Ren J AD - Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. FAU - Chen, Haiyan AU - Chen H AD - Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. FAU - Zhang, Qian AU - Zhang Q AD - Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. zhangqian6088@pumch.cn. FAU - Xiao, Xinhua AU - Xiao X AD - Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. xiaoxh2014@vip.163.com. LA - eng SI - ClinicalTrials.gov/NCT05952739 GR - (Category C, UBJ06088)/Peking Union Medical College Hospital Talent Cultivation Program/ GR - (No. 82170854, 81870579, 81870545)/National Natural Science Foundation of China/ GR - (7202163)/Beijing Natural Science Foundation/ GR - (Z201100005520011),/Beijing Municipal Science & Technology Commission/ GR - (2022-PUMCH-C-019)/National High Level Hospital Clinical Research Funding/ GR - (CIFMS2021-1-I2M-002)/CAMS Innovation Fund for Medical Sciences/ GR - (2023-PT320-10)/the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences/ GR - (APL24100310010302079)/the Fundamental Research Funds for the Central Universities/ PT - Journal Article DEP - 20251227 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Diabetes, Gestational/epidemiology/diagnosis MH - *Hypothyroidism/epidemiology/diagnosis MH - China/epidemiology MH - Prospective Studies MH - Pregnancy Outcome MH - Biomarkers/blood/urine MH - Infant, Newborn MH - Adult MH - Birth Weight MH - Developmental Origins of Health and Disease MH - *Pregnancy Complications/epidemiology PMC - PMC12888118 OTO - NOTNLM OT - Biomarkers OT - Cohort study OT - Gestational diabetes mellitus (GDM) OT - Metabolic health OT - Pregnancy outcomes OT - Risk factors OT - Subclinical hypothyroidism (SCH) COIS- Declarations. Ethics approval and consent to participate: This clinical research protocol was approved by the Ethics Committee of Peking Union Medical College Hospital (I-23PJ162). This study adhered to the Declaration of Helsinki. Informed consent for study participation will be obtained through a signed written informed consent form. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/28 01:36 MHDA- 2026/06/27 00:58 PMCR- 2025/12/27 CRDT- 2025/12/27 23:55 PHST- 2025/08/04 00:00 [received] PHST- 2025/09/26 00:00 [accepted] PHST- 2026/06/27 00:58 [medline] PHST- 2025/12/28 01:36 [pubmed] PHST- 2025/12/27 23:55 [entrez] PHST- 2025/12/27 00:00 [pmc-release] AID - 10.1186/s12884-025-08294-5 [pii] AID - 8294 [pii] AID - 10.1186/s12884-025-08294-5 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2025 Dec 27;26(1):147. doi: 10.1186/s12884-025-08294-5. PMID- 41454820 OWN - NLM STAT- MEDLINE DCOM- 20251227 LR - 20260502 IS - 0971-5916 (Print) IS - 0971-5916 (Linking) VI - 162 IP - 4 DP - 2025 Oct TI - Awareness & knowledge of frontline workers on infant & young child feeding (IYCF) practices: A qualitative study from Palghar-Maharashtra, India. PG - 437-444 LID - 10.25259/IJMR_986_2025 [pii] AB - Background & objectives Appropriate infant and young child feeding (IYCF) practices are crucial for growth and development during the first two years of life. Despite national initiatives, suboptimal IYCF practices prevail in tribal regions, contributing to undernutrition among under- five children. This necessitates need of specific targeted interventions through involvement of front line workers considering their role in community engagement. This study aims to assess awareness and knowledge of frontline workers about IYCF practices in Palghar district of Maharashtra. Methods This paper is part of a pre-intervention phase of a quasi-experimental study on IYCF practices in a tribal block of Palghar district, which included qualitative data through 56 in-depth interviews among frontline workers [anganwadi worker supervisor, anganwadi workers, and accredited social health activists (ASHAs)] to explore their awareness and knowledge on World Health Organization IYCF domains. Data were coded, thematically analysed, and responses were summarised descriptively to identify gaps for the intervention phase. Results While FLWs exhibited basic awareness of breastfeeding, there was limited knowledge among ASHAs on complementary feeding, minimum dietary diversity, minimum meal frequency and amylase rich flour preparation. While FLWs were aware of key IYCF messages, their implementation is uneven, likely due to limited refresher training, and the lack of user-friendly, validated tools. Interpretation & conclusions The study identified specific knowledge gaps in IYCF practices among frontline workers, particularly among ASHAs. There is an adequate scope for targeted health education to address misconceptions and supportive supervision to strengthen frontline workers' capacity to deliver accurate and consistent IYCF messages in tribal communities. FAU - Surve, Suchitra Vishwambhar AU - Surve SV AD - Department of Child Health Research, ICMR-National Institute for Research in Reproductive and Child Health, Dahanu, Mumbai, Maharashtra, India. FAU - Kyatam, Shraddha AU - Kyatam S AD - Department of Operational and Implementation Research, ICMR-National Institute for Research in Reproductive and Child Health, Dahanu, Mumbai, Maharashtra, India. FAU - M K, Bhavya AU - M K B AD - Department of Operational and Implementation Research, ICMR-National Institute for Research in Reproductive and Child Health, Dahanu, Mumbai, Maharashtra, India. FAU - Begum, Shahina AU - Begum S AD - Department of Biostatistics, ICMR-National Institute for Research in Reproductive and Child Health, Dahanu, Mumbai, Maharashtra, India. FAU - Kulkarni, Ragini Nitin AU - Kulkarni RN AD - Department of Operational and Implementation Research, ICMR-National Institute for Research in Reproductive and Child Health, Dahanu, Mumbai, Maharashtra, India. AD - Model Rural Health Research Unit, Dahanu, Mumbai, Maharashtra, India. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Indian J Med Res JT - The Indian journal of medical research JID - 0374701 SB - IM MH - Humans MH - India/epidemiology MH - Infant MH - *Health Knowledge, Attitudes, Practice MH - *Breast Feeding MH - Female MH - *Community Health Workers MH - Child, Preschool MH - Male MH - Qualitative Research MH - Adult MH - *Infant Nutritional Physiological Phenomena MH - Frontline Workers PMC - PMC12744577 OTO - NOTNLM OT - Children OT - IYCF OT - complementary feeding OT - tribal OT - undernutrition COIS- None. EDAT- 2025/12/27 17:51 MHDA- 2025/12/27 17:52 PMCR- 2025/10/01 CRDT- 2025/12/27 07:49 PHST- 2025/04/21 00:00 [received] PHST- 2025/07/29 00:00 [accepted] PHST- 2025/12/27 17:52 [medline] PHST- 2025/12/27 17:51 [pubmed] PHST- 2025/12/27 07:49 [entrez] PHST- 2025/10/01 00:00 [pmc-release] AID - 10.25259/IJMR_986_2025 [pii] AID - 10.25259/IJMR_986_2025 [doi] PST - ppublish SO - Indian J Med Res. 2025 Oct;162(4):437-444. doi: 10.25259/IJMR_986_2025. PMID- 41454789 OWN - NLM STAT- MEDLINE DCOM- 20260322 LR - 20260322 IS - 1532-4303 (Electronic) IS - 0277-0903 (Linking) VI - 63 IP - 4 DP - 2026 Apr TI - Performance of the asthma clinical score and the Pediatric Respiratory Assessment Measure in obese children presenting to the emergency department for asthma exacerbations. PG - 492-500 LID - 10.1080/02770903.2025.2610341 [doi] AB - OBJECTIVE: Our primary objective was to evaluate the interrater reliability (IRR), responsiveness and predictive validity of two asthma severity scores in obese and normal weight (NW) children. Our secondary objective was to compare asthma interventions in these groups. METHODS: This was a planned secondary analysis of a prospective observational study of children aged 2-to- < 18 years treated for asthma exacerbations in the emergency department. Obesity was defined as >95th% sex-specific weight-for-age. Clinicians completed paired assessments of the Asthma Clinical Score (ACS) and Pediatric Respiratory Assessment Measure (PRAM). IRR was analyzed using Cohen's kappa coefficient. Reliable change index was used to determine the responsiveness. Predictive validity of the pretreatment ACS and PRAM was analyzed using Receiver Operating Characteristics and Akaike Information Criterion. The likelihood of receiving an intervention was described using odds ratios (OR). RESULTS: 399 Children were enrolled, 111 classified as obese. In obese children, the ACS showed moderate IRR, while the PRAM showed weak IRR (kappa(w) 0.73 and 0.57, respectively). Both scores better detected responsiveness in NW versus obese children (ACS 34% vs 23%, PRAM 28% vs 3.7%, respectively) but were better predictors of hospitalization in obese children (ACS 0.85, vs 0.74 and PRAM 0.79 vs 0.72, respectively). Obese children had higher odds of receiving intravenous methylprednisolone, continuous albuterol, and noninvasive ventilation. CONCLUSION: Performance of the ACS and PRAM varied between obese and NW children. Future studies should aim to fully elucidate the performance and utility of asthma severity scores in obese children. FAU - Andoh, Adjoa A AU - Andoh AA AUID- ORCID: 0000-0002-9535-1975 AD - Division of Emergency Medicine, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA. AD - The Ohio State University College of Medicine, Columbus, OH, USA. FAU - Truelove, Annie AU - Truelove A AD - Division of Emergency Medicine, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA. AD - The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. FAU - Helwig, Sara AU - Helwig S AD - Division of Emergency Medicine, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA. AD - The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. FAU - Nash, Matthew C AU - Nash MC AD - Division of Emergency Medicine, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA. AD - The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. FAU - Ulrich, Lisa AU - Ulrich L AUID- ORCID: 0000-0002-7232-2442 AD - The Ohio State University College of Medicine, Columbus, OH, USA. AD - Division of Pulmonary, Sleep Medicine and Cystic Fibrosis, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA. FAU - Shell, Richard AU - Shell R AD - The Ohio State University College of Medicine, Columbus, OH, USA. AD - Division of Pulmonary, Sleep Medicine and Cystic Fibrosis, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA. FAU - Leonard, Julie C AU - Leonard JC AD - Division of Emergency Medicine, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA. AD - The Ohio State University College of Medicine, Columbus, OH, USA. AD - The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. LA - eng PT - Journal Article PT - Observational Study DEP - 20260105 PL - England TA - J Asthma JT - The Journal of asthma : official journal of the Association for the Care of Asthma JID - 8106454 RN - 0 (Anti-Asthmatic Agents) SB - IM MH - Humans MH - *Asthma/diagnosis/physiopathology/drug therapy/complications MH - Child MH - *Emergency Service, Hospital/statistics & numerical data MH - Male MH - Female MH - Child, Preschool MH - Prospective Studies MH - *Severity of Illness Index MH - *Pediatric Obesity/complications MH - Adolescent MH - Reproducibility of Results MH - Anti-Asthmatic Agents/therapeutic use OTO - NOTNLM OT - Pediatrics OT - prediction OT - reliability OT - treatment OT - weight EDAT- 2025/12/27 17:51 MHDA- 2026/03/23 01:33 CRDT- 2025/12/27 07:23 PHST- 2026/03/23 01:33 [medline] PHST- 2025/12/27 17:51 [pubmed] PHST- 2025/12/27 07:23 [entrez] AID - 10.1080/02770903.2025.2610341 [doi] PST - ppublish SO - J Asthma. 2026 Apr;63(4):492-500. doi: 10.1080/02770903.2025.2610341. Epub 2026 Jan 5. PMID- 41454183 OWN - NLM STAT- MEDLINE DCOM- 20260407 LR - 20261010 IS - 1476-5497 (Electronic) IS - 0307-0565 (Linking) VI - 50 IP - 4 DP - 2026 Apr TI - A prediction model for childhood obesity risk based on maternal thyroid status and related parameters using machine learning: a mother-newborn-offspring study in a mild-to-moderate iodine deficiency area. PG - 750-759 LID - 10.1038/s41366-025-01988-y [doi] AB - BACKGROUND: Childhood obesity and iodine deficiency are prevalent in developed countries and are linked to adverse health outcomes in adulthood. Mild-to-moderate iodine deficiency and insufficient maternal iodine intake during pregnancy may increase the risk of large-for-gestational-age newborns, which are associated with childhood obesity. Despite this, predicting childhood obesity during pregnancy remains a challenge. We assessed and evaluated machine learning algorithms predicting childhood obesity risk using maternal anthropometrics, thyroid function and iodine intake; and identified key prenatal factors contributing to childhood obesity. METHODS: A diagnostic accuracy study was conducted based on 87 parameters collected from a mother-newborn-offspring prospective cohort (N = 191) in a mild-to-moderate iodine deficiency region. Maternal iodine status and thyroid function, including serum free tri-iodo-thyronine (FT3) concentrations, were assessed during the second half of pregnancy. Iodine intake was evaluated using a semi-quantitative food frequency questionnaire. Anthropometric measurements were obtained from mothers during pregnancy, from newborns at birth, and from children at 2 years of age. An outcome of overweight at 2 years was defined as a gender-adjusted weight percentile >85%. The dataset was split into training (80%) and test (20%) sets. Synthetic datasets were created to evaluate the performance of six machine learning models, including artificial neural networks (Nnet) that trained and evaluated the model using 5-fold cross-validation. RESULTS: The best-performing model was Nnet, which achieved the highest accuracy (1500 instances with a balanced predicted outcome). On the unseen test data, accuracy, Kappa, outcome F1-score and weighted F1 were 0.743, 0.347, 0.500 and 0.769 (respectively). Significant predictors included gravidity, maternal-newborn anthropometrics (height and head circumference, respectively), maternal consumption and dietary intake of iodine-rich foods (popsicle, selected fish, and yogurt) and FT3. CONCLUSIONS: Machine learning approaches show promise in predicting childhood obesity risk using maternal and dietary factors during pregnancy. If validated, these findings could support interventions to reduce childhood obesity rates. CI - (c) 2025. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Ovadia, Yaniv S AU - Ovadia YS AUID- ORCID: 0000-0001-9846-1515 AD - Obstetrics and Gynecology Division, Barzilai University Medical Center, Ashkelon, Israel. yaniv.ovadia@mail.huji.ac.il. FAU - Bilenko, Natalya AU - Bilenko N AD - Medical Office of Southern District, Ministry of Health, Ashkelon, Israel. AD - Faculty of Health Sciences, Ben-Gurion University of Negev, Beersheba, Israel. FAU - Mazza, Orit AU - Mazza O AD - Loewenstein Rehabilitation Medical Center, Ra'anana, Israel. AD - Clalit Health Services, Dan Petah-Tiqwa District, Petah Tikva, Israel. FAU - Fisch-Shvalb, Naama AU - Fisch-Shvalb N AUID- ORCID: 0000-0001-9612-6983 AD - The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petach Tikva, Israel. AD - Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Paradise Vit, Abigail AU - Paradise Vit A AD - Department of Information Systems, The Max Stern Emek Yezreel College, Emek Yezreel, Israel. FAU - Rosen, Shani R AU - Rosen SR AD - School of Nutritional Science; Institute of Biochemistry, Food Science and Nutrition; Robert H. Smith Faculty of Agriculture, Food and Environment; The Hebrew University of Jerusalem, Rehovot, Israel. FAU - Avrahami-Benyounes, Yael AU - Avrahami-Benyounes Y AD - Women's Health Center, Maccabi Healthcare Services, Southern Region, Beersheba, Israel. FAU - Groisman, Ludmila AU - Groisman L AD - National Public Health Laboratory, Ministry of Health, Tel Aviv, Israel. FAU - Rorman, Efrat AU - Rorman E AD - National Public Health Laboratory, Ministry of Health, Tel Aviv, Israel. FAU - Ketslakh, Tatiana AU - Ketslakh T AD - Obstetrics and Gynecology Division, Barzilai University Medical Center, Ashkelon, Israel. FAU - Anteby, Eyal Y AU - Anteby EY AD - Obstetrics and Gynecology Division, Barzilai University Medical Center, Ashkelon, Israel. AD - Faculty of Health Sciences, Ben-Gurion University of Negev, Beersheba, Israel. FAU - Gefel, Dov AU - Gefel D AD - Obstetrics and Gynecology Division, Barzilai University Medical Center, Ashkelon, Israel. FAU - Shenhav, Simon AU - Shenhav S AD - Obstetrics and Gynecology Division, Barzilai University Medical Center, Ashkelon, Israel. AD - Faculty of Health Sciences, Ben-Gurion University of Negev, Beersheba, Israel. LA - eng PT - Journal Article DEP - 20251226 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 RN - 9679TC07X4 (Iodine) SB - IM MH - Humans MH - *Iodine/deficiency MH - Female MH - *Machine Learning MH - *Pediatric Obesity/epidemiology/etiology MH - Pregnancy MH - Infant, Newborn MH - Male MH - Prospective Studies MH - Adult MH - Child, Preschool MH - Risk Factors MH - Mothers/statistics & numerical data MH - *Thyroid Gland/physiopathology COIS- Competing interests: YSO is a named inventor on a pending provisional patent application (U.S. Application No. 63/911,629) describing systems and methods for predicting and mitigating offspring health risks (including predictive models and methods presented in this manuscript). The remaining authors declare that they have no competing financial interests. EDAT- 2025/12/27 00:54 MHDA- 2026/04/08 00:30 CRDT- 2025/12/26 23:20 PHST- 2024/11/25 00:00 [received] PHST- 2025/12/05 00:00 [accepted] PHST- 2025/11/06 00:00 [revised] PHST- 2026/04/08 00:30 [medline] PHST- 2025/12/27 00:54 [pubmed] PHST- 2025/12/26 23:20 [entrez] AID - 10.1038/s41366-025-01988-y [pii] AID - 10.1038/s41366-025-01988-y [doi] PST - ppublish SO - Int J Obes (Lond). 2026 Apr;50(4):750-759. doi: 10.1038/s41366-025-01988-y. Epub 2025 Dec 26. PMID- 41454046 OWN - NLM STAT- MEDLINE DCOM- 20260407 LR - 20260919 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 1 DP - 2025 Dec 27 TI - Ultrasonographic predictors of extubation success in children: diaphragmatic, lung, and laryngeal assessment-a prospective pilot cohort study. PG - 42 LID - 10.1007/s00431-025-06677-6 [doi] LID - 42 AB - Extubation failure, occurring in 3-22% of pediatric intensive care unit (PICU) patients, contributes to increased morbidity, prolonged hospitalization, and healthcare costs. Point-of-care ultrasound (POCUS) provides a bedside, radiation-free method to assess extubation readiness. This pilot study evaluated the predictive value of lung, diaphragmatic, and laryngeal ultrasound for extubation success in mechanically ventilated children. In this prospective pilot study, 30 children (22 males, 8 females; aged 1 month-14 years) ventilated for > 24 h were enrolled. Patients with congenital diaphragmatic, pulmonary, or laryngeal abnormalities were excluded. Ultrasound examinations of the diaphragm, lungs, and larynx were performed within 24 h before and after extubation. Patients were classified as successful or failed extubation (reintubation within 48 h). Receiver operating characteristic (ROC) curve analysis was used to determine optimal cut-off values. Extubation succeeded in 18 (60%) and failed in 12 (40%) patients. Diaphragmatic excursion > 5.5 mm was the strongest predictor (sensitivity 100%, specificity 91.7%). Diaphragmatic thickening fraction > 29% (sensitivity 88.9%, specificity 66.7%); lung ultrasound score < 16.5 (sensitivity and specificity 80%); and body mass index > 14.8 (sensitivity 100%, specificity 63.6%) were also significant predictors. Reduced laryngeal air width difference moderately predicted failure (specificity 83.3%, p = 0.025). CONCLUSION: Diaphragmatic excursion and thickening fraction are the most accurate ultrasound predictors of extubation success, with lung and laryngeal assessments providing complementary insights. Combining these modalities may improve bedside evaluation of extubation readiness in critically ill children. WHAT IS KNOWN: * Extubation failure remains frequent in pediatric intensive care units, and currently used clinical predictors have limited reliability. * Bedside ultrasonography enables non-invasive assessment of diaphragmatic, pulmonary, and laryngeal function in critically ill children. WHAT IS NEW: * This pilot study integrates diaphragmatic, lung, and laryngeal ultrasonography into a single bedside extubation assessment strategy in children. * Diaphragmatic excursion and diaphragmatic thickening fraction emerged as the strongest ultrasound predictors of extubation success. CI - (c) 2025. The Author(s). FAU - Rezk, Ahmed R AU - Rezk AR AD - Pediatric Intensive Care Unit, Children's Hospital, Ain Shams University, Cairo, Egypt. FAU - Ibrahim, Hanan M AU - Ibrahim HM AD - Pediatric Intensive Care Unit, Children's Hospital, Ain Shams University, Cairo, Egypt. FAU - Yousry, Mahmoud AU - Yousry M AD - Pediatric Intensive Care Unit, Children's Hospital, Ain Shams University, Cairo, Egypt. FAU - Gamal, Assad AU - Gamal A AD - Radiology Department, Children's Hospital, Ain Shams University, Cairo, Egypt. FAU - Magdy, Sondos M AU - Magdy SM AUID- ORCID: 0000-0002-2832-7799 AD - Pediatric Intensive Care Unit, Children's Hospital, Ain Shams University, Cairo, Egypt. sondosmmagdy@med.asu.edu.eg. LA - eng PT - Journal Article DEP - 20251227 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Prospective Studies MH - Pilot Projects MH - *Ultrasonography/classification/methods MH - *Airway Extubation/classification/methods MH - Diaphragm/diagnostic imaging/pathology MH - Lung/diagnostic imaging/pathology MH - Larynx/diagnostic imaging/pathology MH - Intensive Care Units, Pediatric MH - *Point-of-Care Testing MH - Predictive Value of Tests MH - Humans MH - Male MH - Female MH - Infant, Newborn MH - Infant MH - Child, Preschool MH - Child MH - Adolescent MH - ROC Curve MH - Body Mass Index MH - Respiration, Artificial MH - *Ventilator Weaning/methods PMC - PMC12743022 OTO - NOTNLM OT - Critical care OT - Extubation failure OT - POCUS OT - Pediatric OT - Pilot study OT - Ultrasonography COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Faculty of Medicine, Ain Shams University Research Ethics Committee (FMASU REC; approval No. FMASU MD103/2023), which operates under Federal Wide Assurance No. FWA000017585. Written informed consent was obtained from parents or legal guardians prior to enrollment, in accordance with the Declaration of Helsinki. Consent for publication: Written informed consent for publication of the patient's clinical details was obtained from the parents or caregivers of patients. Competing interests: The authors declare no competing interests. EDAT- 2025/12/27 00:54 MHDA- 2025/12/27 00:55 PMCR- 2025/12/27 CRDT- 2025/12/26 23:17 PHST- 2025/10/13 00:00 [received] PHST- 2025/11/28 00:00 [accepted] PHST- 2025/11/15 00:00 [revised] PHST- 2025/12/27 00:55 [medline] PHST- 2025/12/27 00:54 [pubmed] PHST- 2025/12/26 23:17 [entrez] PHST- 2025/12/27 00:00 [pmc-release] AID - 10.1007/s00431-025-06677-6 [pii] AID - 6677 [pii] AID - 10.1007/s00431-025-06677-6 [doi] PST - epublish SO - Eur J Pediatr. 2025 Dec 27;185(1):42. doi: 10.1007/s00431-025-06677-6. PMID- 41453585 OWN - NLM STAT- MEDLINE DCOM- 20260213 LR - 20260318 IS - 1873-1708 (Electronic) IS - 0890-6238 (Linking) VI - 140 DP - 2026 Mar TI - Childhood susceptibility to PFAS-associated endocrine disruption: NHANES age-stratified analysis and PFOS mouse model validation. PG - 109152 LID - S0890-6238(25)00323-5 [pii] LID - 10.1016/j.reprotox.2025.109152 [doi] AB - Mixed exposure to per- and polyfluoroalkyl substances (PFAS) has been associated with altered male endocrine function, but age-specific susceptibility is uncertain. We analyzed 1965 males aged 6-80 years in NHANES 2013-2018, relating PFOS, PFOA, PFHxS, and PFNA to estradiol (E2) and sex hormone-binding globulin (SHBG) with survey-weighted linear models; mixture effects were assessed by weighted quantile sum (WQS) and Bayesian kernel machine regression (BKMR) within age strata. Associations were strongest at ages 6-12: PFOS was associated with higher E2, whereas PFOA and PFNA were associated with lower SHBG, with supportive evidence for PFHxS. Mixture analyses identified PFOS as a main contributor and suggested nonlinear PFOS-E2 increases and monotonic SHBG suppression by PFOA/PFHxS. Juvenile mice received PFOS in drinking water for six weeks; PFOS altered hormones and induced germ-cell injury, consistent with the human window. Our findings suggest that childhood may be a sensitive period for PFAS-related endocrine disruption, warranting child-focused monitoring and mixture-aware risk assessment. CI - Copyright (c) 2025 Elsevier Inc. All rights reserved. FAU - Yang, Qiming AU - Yang Q AD - Department of Environmental Toxicology, School of Public Health, Shandong Second Medical University, Weifang 261053, PR China; Institute of Environment and Health, South China Hospital, Medical School, Shenzhen University, Shenzhen 518116, PR China. FAU - Bai, Wenxin AU - Bai W AD - Department of Environmental Toxicology, School of Public Health, Shandong Second Medical University, Weifang 261053, PR China. FAU - Liu, Yujun AU - Liu Y AD - Institute of Environment and Health, South China Hospital, Medical School, Shenzhen University, Shenzhen 518116, PR China; Department of Urology, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, PR China. FAU - Huang, Xiuxian AU - Huang X AD - Institute of Environment and Health, South China Hospital, Medical School, Shenzhen University, Shenzhen 518116, PR China. FAU - Zou, Bing AU - Zou B AD - Institute of Environment and Health, South China Hospital, Medical School, Shenzhen University, Shenzhen 518116, PR China. FAU - Muhammad, Zubair AU - Muhammad Z AD - Institute of Environment and Health, South China Hospital, Medical School, Shenzhen University, Shenzhen 518116, PR China. FAU - Farooq, Uswa AU - Farooq U AD - Institute of Environment and Health, South China Hospital, Medical School, Shenzhen University, Shenzhen 518116, PR China. FAU - Zhai, Qingfeng AU - Zhai Q AD - Department of Environmental Toxicology, School of Public Health, Shandong Second Medical University, Weifang 261053, PR China. Electronic address: sdzzqqff@163.com. FAU - Liu, Nan AU - Liu N AD - Department of Environmental Toxicology, School of Public Health, Shandong Second Medical University, Weifang 261053, PR China; Institute of Environment and Health, South China Hospital, Medical School, Shenzhen University, Shenzhen 518116, PR China; Marshall Laboratory of Biomedical Engineering, Shenzhen University, Shenzhen 518116, PR China. Electronic address: nanliu@szu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251224 PL - United States TA - Reprod Toxicol JT - Reproductive toxicology (Elmsford, N.Y.) JID - 8803591 RN - 0 (Fluorocarbons) RN - 0 (Endocrine Disruptors) RN - 0 (Alkanesulfonic Acids) RN - 4TI98Z838E (Estradiol) RN - 0 (Sex Hormone-Binding Globulin) RN - 0 (Environmental Pollutants) RN - 9H2MAI21CL (perfluorooctane sulfonic acid) RN - 0 (Caprylates) RN - 947VD76D3L (perfluorooctanoic acid) SB - IM MH - *Fluorocarbons/toxicity MH - Animals MH - Male MH - Child MH - *Endocrine Disruptors/toxicity MH - Middle Aged MH - Adolescent MH - Adult MH - Humans MH - *Alkanesulfonic Acids/toxicity MH - Aged MH - Young Adult MH - Mice MH - Nutrition Surveys MH - Estradiol/blood MH - Aged, 80 and over MH - Sex Hormone-Binding Globulin/metabolism/analysis MH - *Environmental Pollutants/toxicity MH - Caprylates/toxicity MH - Age Factors OTO - NOTNLM OT - Age-dependent susceptibility OT - Estradiol (E2) OT - Male reproductive health OT - Per- and polyfluoroalkyl substances (PFAS) OT - Perfluorooctane sulfonate (PFOS) OT - Sex hormone-binding globulin (SHBG) COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/12/27 00:54 MHDA- 2026/02/14 05:30 CRDT- 2025/12/26 19:34 PHST- 2025/10/09 00:00 [received] PHST- 2025/12/19 00:00 [revised] PHST- 2025/12/24 00:00 [accepted] PHST- 2026/02/14 05:30 [medline] PHST- 2025/12/27 00:54 [pubmed] PHST- 2025/12/26 19:34 [entrez] AID - S0890-6238(25)00323-5 [pii] AID - 10.1016/j.reprotox.2025.109152 [doi] PST - ppublish SO - Reprod Toxicol. 2026 Mar;140:109152. doi: 10.1016/j.reprotox.2025.109152. Epub 2025 Dec 24. PMID- 41452894 OWN - NLM STAT- MEDLINE DCOM- 20251226 LR - 20251229 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 12 DP - 2025 TI - Spiritual well-being as a protective factor for endothelial dysfunction in clinically healthy adults. PG - e0339676 LID - 10.1371/journal.pone.0339676 [doi] LID - e0339676 AB - BACKGROUND: Endothelial dysfunction (ED) is an early marker of cardiovascular disease (CVD), influenced by both physiological and psychosocial factors. While depression and anxiety are known contributors to ED, the role of spiritual well-being (SWB) in vascular health has been relatively less explored in the literature. OBJECTIVE: To investigate the association between SWB and ED in clinically healthy adults, controlling for mental health variables and conventional cardiovascular risk factors. METHODS: In this cross-sectional study, 148 individuals aged 18-60 years were assessed using validated instruments: FACIT-Sp for SWB, PHQ-9 for depression, GAD-7 for anxiety, and brachial artery flow-mediated dilation (FMD) for endothelial function. Logistic regression and discriminant analyses were performed to identify independent predictors of ED and the spiritual dimensions most associated with vascular health. RESULTS: ED was identified in 39.2% of participants. Multivariate logistic regression indicated that SWB (OR = 0.929; p = 0.005), body mass index (OR = 1.130; p = 0.016), generalized anxiety disorder (OR = 2.551; p = 0.035), and major depressive episode (OR = 3.740; p = 0.038), were significantly associated with ED. Among these, SWB was significantly inversely associated with ED even after excluding participants with anxiety or depression. Discriminant analysis further indicated that inner peace and life purpose-but not faith-significantly distinguished individuals with and without ED. CONCLUSION: SWB, particularly dimensions related to inner peace and meaning, is independently associated with preserved endothelial function in healthy adults. These findings support the inclusion of psychosocial and spiritual dimensions in cardiovascular risk assessment and prevention strategies. CI - Copyright: (c) 2025 Casarsa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Casarsa, Andre AU - Casarsa A AUID- ORCID: 0000-0003-1043-9335 AD - Department of Internal Medicine, University Hospital Gaffree Guinle, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. AD - Postgraduate Neurology Department, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Bastos de Medeiros, Pedro AU - Bastos de Medeiros P AUID- ORCID: 0009-0006-9558-2235 AD - Department of Internal Medicine, University Hospital Gaffree Guinle, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. AD - Department of Internal Medicine, University Hospital Clementino Fraga Filho, Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Tolentino, Julio Cesar AU - Tolentino JC AUID- ORCID: 0000-0002-2524-9836 AD - Department of Internal Medicine, University Hospital Gaffree Guinle, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. AD - Postgraduate Neurology Department, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Guimaraes, Isadora de Sa AU - Guimaraes IS AUID- ORCID: 0009-0001-2489-3304 AD - Department of Internal Medicine, University Hospital Gaffree Guinle, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Cruz, Kelen Carolina Silva AU - Cruz KCS AD - Department of Internal Medicine, University Hospital Gaffree Guinle, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Dos Santos, Leticia Silva Flor AU - Dos Santos LSF AUID- ORCID: 0009-0002-2658-2443 AD - Department of Internal Medicine, University Hospital Gaffree Guinle, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Tinoco, Matheus Nakazato AU - Tinoco MN AUID- ORCID: 0009-0004-6734-3451 AD - Department of Internal Medicine, University Hospital Gaffree Guinle, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Dias, Maria de Fatima Martins Gil AU - Dias MFMG AUID- ORCID: 0009-0003-0572-1069 AD - Postgraduate Neurology Department, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Gjorup, Ana Lucia Taboada AU - Gjorup ALT AD - Department of Internal Medicine, University Hospital Gaffree Guinle, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. AD - Postgraduate Neurology Department, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Schmidt, Sergio Luis AU - Schmidt SL AUID- ORCID: 0000-0001-7654-5507 AD - Department of Internal Medicine, University Hospital Gaffree Guinle, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. AD - Postgraduate Neurology Department, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro, Rio de Janeiro, Brazil. LA - eng PT - Journal Article DEP - 20251226 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Adult MH - Male MH - Female MH - Middle Aged MH - *Spirituality MH - Cross-Sectional Studies MH - *Endothelium, Vascular/physiopathology MH - Young Adult MH - Adolescent MH - *Cardiovascular Diseases/psychology/physiopathology MH - Depression MH - Risk Factors MH - Anxiety MH - Protective Factors PMC - PMC12742740 COIS- The authors have declared that no competing interests exist. EDAT- 2025/12/26 18:29 MHDA- 2025/12/26 18:30 PMCR- 2025/12/26 CRDT- 2025/12/26 13:43 PHST- 2025/06/19 00:00 [received] PHST- 2025/12/08 00:00 [accepted] PHST- 2025/12/26 18:30 [medline] PHST- 2025/12/26 18:29 [pubmed] PHST- 2025/12/26 13:43 [entrez] PHST- 2025/12/26 00:00 [pmc-release] AID - PONE-D-25-31113 [pii] AID - 10.1371/journal.pone.0339676 [doi] PST - epublish SO - PLoS One. 2025 Dec 26;20(12):e0339676. doi: 10.1371/journal.pone.0339676. eCollection 2025. PMID- 41452440 OWN - NLM STAT- MEDLINE DCOM- 20260406 LR - 20261010 IS - 1720-8386 (Electronic) IS - 0391-4097 (Linking) VI - 49 IP - 4 DP - 2026 Apr TI - TRISOMY 21: development of syndrome-specific growth charts from a wide Italian cohort and validation of BMI as a predictor of increased risk of metabolic derangement. PG - 931-946 LID - 10.1007/s40618-025-02777-0 [doi] AB - PURPOSE: The growth charts for individuals with Down syndrome (DS) available to-date were developed from a cohort of patients from the USA. As diet and environmental factors play a key role on auxological attainment, the growth of patients from the Mediterranean area should be assessed by means of dedicated centiles. Accordingly, we aimed to develop growth charts from a wide Italian population and to provide a metabolic validation for the BMI distribution outlined. METHODS: Retrospective, bicentric study. We gathered auxological and biochemical data from two cohorts of Italian children and adolescents with DS assessed every 6- to 12-months between 1992 and 2024. RESULTS: 526 patients were enrolled. We longitudinally retrieved the auxological data recorded in the setting of 2796 clinical evaluations. By assessing height, weight and BMI with reference to age, we outlined the age-dependent distribution of each parameter and developed syndrome-specific growth charts. When comparing our charts with the USA ones, the latter showed a statistically greater upward trendline in weight and BMI. Eventually, we assessed the distribution of triglycerides, cholesterol, glycated hemoglobin and uric acid with reference to the BMI. A higher BMI centile was statistically associated with greater triglycerides, cholesterol, and uric acid levels, and we identified the 90th centile of BMI as a risk threshold for dyslipidemia and hyperuricemia. CONCLUSION: We developed DS-specific growth charts from a wide Italian population. The comparison with the USA percentiles outlined statistically significant differences in the distribution of weight and BMI, thus highlighting the need of dedicated charts for individuals from the Mediterranean area. CI - (c) 2025. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE). FAU - Cattoni, Alessandro AU - Cattoni A AUID- ORCID: 0000-0001-6933-6723 AD - Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, 20900, Monza, MB, Italy. alessandro.cattoni@unimib.it. FAU - Molinari, Silvia AU - Molinari S AD - Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, 20900, Monza, MB, Italy. FAU - Cali, Luisa AU - Cali L AD - School of Medicine and Surgery, University of Milano-Bicocca, Monza, MB, Italy. FAU - Riva, Benedetta AU - Riva B AD - School of Medicine and Surgery, University of Milano-Bicocca, Monza, MB, Italy. FAU - Nicolosi, Maria Laura AU - Nicolosi ML AD - Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, 20900, Monza, MB, Italy. FAU - Fossati, Chiara AU - Fossati C AD - Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, 20900, Monza, MB, Italy. FAU - Gazzarri, Alessandra AU - Gazzarri A AD - Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, 20900, Monza, MB, Italy. AD - Vivi Down Odv, Milano, MI, Italy. FAU - Lattuada, Martina AU - Lattuada M AD - School of Medicine and Surgery, University of Milano-Bicocca, Monza, MB, Italy. FAU - Medici, Francesco AU - Medici F AD - School of Medicine and Surgery, University of Milano-Bicocca, Monza, MB, Italy. FAU - Carzaniga, Viola AU - Carzaniga V AD - School of Medicine and Surgery, University of Milano-Bicocca, Monza, MB, Italy. FAU - Carnevale, Riccardo AU - Carnevale R AD - School of Medicine and Surgery, University of Milano-Bicocca, Monza, MB, Italy. FAU - Pangallo, Elisabetta AU - Pangallo E AD - School of Medicine and Surgery, University of Milano-Bicocca, Monza, MB, Italy. FAU - Primi, Marianna AU - Primi M AD - B4 Center of Bioinformatics, Biostatistics e Bioimaging, University of Milano-Bicocca, Vedano al Lambro, MB, Italy. FAU - Bonfanti, Cristina AU - Bonfanti C AD - Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, 20900, Monza, MB, Italy. FAU - Balduzzi, Adriana AU - Balduzzi A AD - Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, 20900, Monza, MB, Italy. AD - School of Medicine and Surgery, University of Milano-Bicocca, Monza, MB, Italy. FAU - Capitoli, Giulia AU - Capitoli G AD - B4 Center of Bioinformatics, Biostatistics e Bioimaging, University of Milano-Bicocca, Vedano al Lambro, MB, Italy. AD - Biostatistics and Clinical Epidemiology, Fondazione IRCCS San Gerardo dei Tintori, Monza, MB, Italy. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20251226 PL - Italy TA - J Endocrinol Invest JT - Journal of endocrinological investigation JID - 7806594 SB - IM MH - Humans MH - *Down Syndrome/epidemiology/complications/physiopathology/diagnosis MH - Female MH - Male MH - *Body Mass Index MH - Italy/epidemiology MH - Retrospective Studies MH - Child MH - Adolescent MH - *Growth Charts MH - Child, Preschool MH - *Metabolic Syndrome/epidemiology/diagnosis/etiology MH - Infant MH - Risk Factors MH - Prognosis MH - Follow-Up Studies MH - Body Height MH - Body Weight OTO - NOTNLM OT - Body mass index OT - Cholesterol OT - Down syndrome OT - Growth charts OT - Metabolism OT - Uric acid COIS- Declarations. Competing interests: The authors have no competing interests to declare that are relevant to the content of this article. EDAT- 2025/12/26 13:39 MHDA- 2026/04/06 18:33 CRDT- 2025/12/26 11:07 PHST- 2025/07/27 00:00 [received] PHST- 2025/11/25 00:00 [accepted] PHST- 2026/04/06 18:33 [medline] PHST- 2025/12/26 13:39 [pubmed] PHST- 2025/12/26 11:07 [entrez] AID - 10.1007/s40618-025-02777-0 [pii] AID - 10.1007/s40618-025-02777-0 [doi] PST - ppublish SO - J Endocrinol Invest. 2026 Apr;49(4):931-946. doi: 10.1007/s40618-025-02777-0. Epub 2025 Dec 26. PMID- 41450131 OWN - NLM STAT- Publisher LR - 20251226 IS - 1532-530X (Electronic) IS - 1064-0266 (Linking) DP - 2025 Dec 26 TI - How do adult inpatients with ARFID or AN-R compare on self-report eating disorder assessments? PG - 1-14 LID - 10.1080/10640266.2025.2608345 [doi] AB - The Pica, ARFID, and Rumination Disorder ARFID Questionnaire (PARDI-AR-Q) and the Eating Disorders in Youth Questionnaire (EDY-Q) were developed to assess avoidant/restrictive food intake disorder (ARFID), but research is ongoing regarding their discriminant validity. This study examined scores of adult inpatients with ARFID or anorexia nervosa, restricting type (AN-R) on the PARDI-AR-Q, EDY-Q, and Eating Disorder Examination Questionnaire (EDE-Q) at admission to a medical stabilization unit for severe eating disorders. Response differences between 78 adult inpatients with ARFID or AN-R were analyzed using a two-sample t-test or Fisher's exact test. Sensitivity and specificity of self-report measures were examined using receiver operating characteristic curves. Patients with AN-R had significantly higher severity of impact and lower concern about aversive consequences scores than patients with ARFID on the PARDI-AR-Q (p < .001), with no significant differences on sensory-based avoidance or lack of interest or EDY-Q total score. Patients with AN-R scored significantly higher on all domains of the EDE-Q (p's < .001) and the EDE-Q subscales had better discrimination than ARFID measures. This study provides further evidence of the need for assessments that can distinguish ARFID from AN, and may also highlight the need for future research on the nosological accuracy of differentiating these disorders. FAU - Manwaring, Jamie L AU - Manwaring JL AUID- ORCID: 0000-0002-7798-0612 AD - ACUTE Center for Eating Disorders and Severe Malnutrition at Denver Health, Denver, CO, USA. AD - Department of Medicine, University of Colorado School of Medicine, Denver, CO, USA. AD - Eating Recovery Center and Pathlight Behavioral Health Centers, Denver, CO, USA. FAU - Cass, Kamila AU - Cass K AD - ACUTE Center for Eating Disorders and Severe Malnutrition at Denver Health, Denver, CO, USA. AD - Department of Medicine, University of Colorado School of Medicine, Denver, CO, USA. FAU - Prostko, Sara AU - Prostko S AD - Department of Psychology, Florida State University, Tallahassee, FL, USA. FAU - Stein, Amy Buros AU - Stein AB AD - Center for Health Systems Research, Denver Health and Hospitals, Denver, CO, USA. FAU - Mehler, Philip S AU - Mehler PS AD - ACUTE Center for Eating Disorders and Severe Malnutrition at Denver Health, Denver, CO, USA. AD - Department of Medicine, University of Colorado School of Medicine, Denver, CO, USA. AD - Eating Recovery Center and Pathlight Behavioral Health Centers, Denver, CO, USA. FAU - Joiner, Thomas AU - Joiner T AUID- ORCID: 0000-0001-6798-9085 AD - Department of Psychology, Florida State University, Tallahassee, FL, USA. FAU - Rienecke, Renee D AU - Rienecke RD AD - Eating Recovery Center and Pathlight Behavioral Health Centers, Denver, CO, USA. AD - Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, USA. LA - eng PT - Journal Article DEP - 20251226 PL - United States TA - Eat Disord JT - Eating disorders JID - 9315161 SB - IM EDAT- 2025/12/26 07:40 MHDA- 2025/12/26 07:40 CRDT- 2025/12/26 03:42 PHST- 2025/12/26 07:40 [medline] PHST- 2025/12/26 07:40 [pubmed] PHST- 2025/12/26 03:42 [entrez] AID - 10.1080/10640266.2025.2608345 [doi] PST - aheadofprint SO - Eat Disord. 2025 Dec 26:1-14. doi: 10.1080/10640266.2025.2608345. PMID- 41449688 OWN - NLM STAT- MEDLINE DCOM- 20260331 LR - 20260813 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2025 Dec 26 TI - Influence of lifestyle and eating behaviours on Mediterranean diet adherence in preschoolers from southern Spain. PG - e56 LID - 10.1017/S1368980025101742 [doi] LID - e56 AB - OBJECTIVE: The present study examined the association of screen and sleep time, physical fitness and eating behaviour with Mediterranean diet (MD) adherence in a sample of preschoolers from Granada, Spain. DESIGN: A cross-sectional, non-randomised design was employed. A multilinear regression model with backward elimination was used for analysis. SETTING: Variables included age, screen time, hours of nightly sleep, physical fitness, food approach and food avoidance. The developed model met assumptions of multiple regression in terms of linearity, homoscedasticity, normality, independence and non-multicollinearity. PARTICIPANTS: Data were collected from 653 of the 2250 three-to-six-year-old children attending the eighteen schools invited to take part in the present study. Data on children's behaviours were parent-reported using validated questionnaires. RESULTS: Better sleep time and lower screen time and food avoidance were found to be predictive of MD adherence. These variables explained 15 % of the variance in preschoolers' MD adherence. CONCLUSIONS: The present study suggests that sleep and screen time and food avoidance are important components to consider when targeting improvements in MD adherence in preschoolers. Future research should explore the way in which parental health behaviours influence their children's health habits in order to better understand the outcomes. FAU - Villodres, Gracia Cristina AU - Villodres GC AUID- ORCID: 0000-0002-8304-5719 AD - Department of Didactics of Corporal Expression, Faculty of Education, https://ror.org/04njjy449University of Granada, Granada, Spain. FAU - Padial-Ruz, Rosario AU - Padial-Ruz R AD - Department of Didactics of Corporal Expression, Faculty of Education, https://ror.org/04njjy449University of Granada, Granada, Spain. FAU - Perez-Diaz, Juan Jose AU - Perez-Diaz JJ AD - Department of Physical Education and Sports, Faculty of Sports Sciences, University of Granada, Granada, Spain. FAU - Muros, Jose Joaquin AU - Muros JJ AUID- ORCID: 0000-0001-7573-0399 AD - Department of Didactics of Corporal Expression, Faculty of Education, https://ror.org/04njjy449University of Granada, Granada, Spain. LA - eng PT - Journal Article DEP - 20251226 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - *Diet, Mediterranean/statistics & numerical data MH - Spain MH - Male MH - Female MH - Cross-Sectional Studies MH - Child, Preschool MH - *Feeding Behavior MH - Sleep MH - Child MH - *Life Style MH - Screen Time MH - Surveys and Questionnaires MH - *Child Behavior MH - *Health Behavior PMC - PMC13112296 OTO - NOTNLM OT - Childhood OT - Healthy behaviours OT - Quality diet OT - Sedentary behaviours COIS- There are no conflicts of interest. EDAT- 2025/12/26 07:40 MHDA- 2026/03/31 06:59 PMCR- 2025/12/26 CRDT- 2025/12/26 01:02 PHST- 2026/03/31 06:59 [medline] PHST- 2025/12/26 07:40 [pubmed] PHST- 2025/12/26 01:02 [entrez] PHST- 2025/12/26 00:00 [pmc-release] AID - S1368980025101742 [pii] AID - 10.1017/S1368980025101742 [doi] PST - epublish SO - Public Health Nutr. 2025 Dec 26;29(1):e56. doi: 10.1017/S1368980025101742. PMID- 41446995 OWN - NLM STAT- MEDLINE DCOM- 20251225 LR - 20251225 IS - 0300-5283 (Print) IS - 0300-5283 (Linking) VI - 80 IP - Suppl 6 DP - 2025 Dec TI - Depression prevalence and its associated factors among sub-urban residents in Kuala Nerus. PG - 8-15 AB - INTRODUCTION: Depression is a prevalent mental health disorder and a growing public health concern. Understanding its burden, this study aimed to determine the prevalence of depression and identify its associated factors among suburban adult residents of Kuala Nerus, Malaysia. MATERIALS AND METHODS: A community-based cross-sectional study was conducted among 689 adults aged 18 and above who had resided in a suburban area for at least one month and were proficient in Bahasa Malaysia. Data were collected through a house-to-house survey using a pre-tested, validated questionnaire administered via Google Form. Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9), and multiple logistic regression analysis was performed to identify associated factors. RESULTS: The prevalence of depression among respondents was 26.4% (95% CI: 23.1, 29.7). Multiple logistic regression analysis identified several significant factors associated with depression. Older age (adjusted OR: 0.972, 95% CI: 0.948, 0.996; p=0.020), being married (adjusted OR: 0.377, 95% CI: 0.188, 0.754; p=0.006), engaging in physical activity (adjusted OR: 0.669, 95% CI: 0.459, 0.976; p=0.037), and higher total knowledge scores (adjusted OR: 0.883, 95% CI: 0.825, 0.945; p < 0.001) were less likely to have depression. Conversely, being female (adjusted OR: 1.614, 95% CI: 1.076, 2.421; p=0.021) and having a history of depression (adjusted OR: 2.977, 95% CI: 1.122, 7.899; p=0.028) were more likely to have depression. CONCLUSION: The study highlights the substantial burden of depression in suburban communities and underscores the need for targeted mental health interventions. Efforts to improve mental health literacy and promote protective factors, particularly among vulnerable groups such as younger individuals and females, are essential. Further research is warranted to develop effective prevention and treatment strategies. FAU - Aung, M M T AU - Aung MMT AD - Universiti Sultan Zainal Abidin, Department of Community Medicine, Kampus Perubatan, Kuala Terengganu, Malaysia. FAU - Oo, S S AU - Oo SS AD - Universiti Sultan Zainal Abidin, Department of Community Medicine, Kampus Perubatan, Kuala Terengganu, Malaysia. sansanoo@unisza.edu.my. FAU - Mat Azmi, I S M AU - Mat Azmi ISM AD - Universiti Sultan Zainal Abidin, Department of Community Medicine, Kampus Perubatan, Kuala Terengganu, Malaysia. FAU - Megat Mustaqim, M I AU - Megat Mustaqim MI AD - Universiti Sultan Zainal Abidin, Department of Community Medicine, Kampus Perubatan, Kuala Terengganu, Malaysia. FAU - Mazlan, A AU - Mazlan A AD - Universiti Sultan Zainal Abidin, Department of Community Medicine, Kampus Perubatan, Kuala Terengganu, Malaysia. FAU - Naing, N N AU - Naing NN AD - Universiti Sultan Zainal Abidin, Department of Community Medicine, Kampus Perubatan, Kuala Terengganu, Malaysia. FAU - Nik Mahdi, N N R AU - Nik Mahdi NNR AD - Universiti Sultan Zainal Abidin, Department of Community Medicine, Kampus Perubatan, Kuala Terengganu, Malaysia. FAU - Aniza, A A AU - Aniza AA AD - Universiti Sultan Zainal Abidin, Department of Community Medicine, Kampus Perubatan, Kuala Terengganu, Malaysia. FAU - Abas, M I AU - Abas MI AD - Universiti Sultan Zainal Abidin, Department of Community Medicine, Kampus Perubatan, Kuala Terengganu, Malaysia. LA - eng PT - Journal Article PL - Malaysia TA - Med J Malaysia JT - The Medical journal of Malaysia JID - 0361547 SB - IM MH - Humans MH - Malaysia/epidemiology MH - Female MH - Male MH - Adult MH - Middle Aged MH - Cross-Sectional Studies MH - Prevalence MH - *Depression/epidemiology MH - Young Adult MH - Risk Factors MH - Adolescent MH - Aged MH - *Suburban Population/statistics & numerical data MH - Surveys and Questionnaires MH - Logistic Models EDAT- 2025/12/25 07:40 MHDA- 2025/12/25 12:37 CRDT- 2025/12/25 05:43 PHST- 2025/12/25 12:37 [medline] PHST- 2025/12/25 07:40 [pubmed] PHST- 2025/12/25 05:43 [entrez] PST - ppublish SO - Med J Malaysia. 2025 Dec;80(Suppl 6):8-15. PMID- 41445558 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251225 LR - 20251227 IS - 2473-4039 (Electronic) IS - 2473-4039 (Linking) VI - 9 IP - Suppl 5 DP - 2025 Dec TI - Harmonized Tubular Maximum Phosphate reabsorption per Glomerular Filtration Rate reporting in adults and children in Australia and New Zealand. PG - v94-v100 LID - 10.1093/jbmrpl/ziae140 [doi] AB - Tubular maximum phosphate reabsorption per glomerular filtration rate (TmP/GFR) is a key diagnostic test for renal phosphate wasting. However, there is a lack of international consensus regarding the reporting of age-related reference intervals. The TmP/GFR Harmonization Working Group, formed by The Australasian Association for Clinical Biochemistry (AACB) and Laboratory Medicine and The Australian and New Zealand Bone and Mineral Society (ANZBMS), aimed to evaluate analytical differences amongst commercial creatinine and phosphate assays, harmonize age-specific cut-offs and compare the ANZBMS TmP/GFR online calculator with existing products. A total of 11 360 results from The Royal College of Pathologists of Australasia Quality Assurance Programs were analyzed to assess creatinine and phosphate assay performance amongst 5 in vitro diagnostic (IVD) companies. Ortho-Clinical Diagnostics analyzers had a positive bias of up to 32% for serum phosphate and up to 29% for TmP/GFR. The other IVD companies produced comparable results and are suitable for harmonized reference intervals. To date, the AACB-ANZBMS TmP/GFR online calculator is the only validated Isotope Dilution Mass Spectrometry-creatinine aligned tool which caters for both pediatric and adult individuals, providing automatic interpretive comments to aid clinicians managing patients with hypophosphatemia. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research. FAU - Chiang, Cherie AU - Chiang C AD - Department of Medicine, University of Melbourne, Parkville, VIC 3050, Australia. AD - Department of Endocrinology, Austin Health, Heidelberg, VIC 3084, Australia. FAU - Choy, Kay Weng AU - Choy KW AD - Department of Pathology, Northern Health, Epping, VIC 3076, Australia. FAU - Coates, Penelope AU - Coates P AD - Department of Chemical Pathology, SA Pathology, Adelaide, SA 5000, Australia. FAU - Carrivick, Simon AU - Carrivick S AD - Department of Biochemistry, Pathwest QEII Medical Centre, Nedlands, SA 6009 Australia. FAU - Farrell, Christopher J AU - Farrell CJ AD - New South Wales Health Pathology, Liverpool Hospital, Liverpool, NSW 2170, Australia. FAU - Clifton-Bligh, Roderick J AU - Clifton-Bligh RJ AD - Department of Endocrinology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia. FAU - Lim, Ee Mun AU - Lim EM AD - Department of Biochemistry, Pathwest QEII Medical Centre, Nedlands, SA 6009 Australia. LA - eng PT - Journal Article DEP - 20251206 PL - England TA - JBMR Plus JT - JBMR plus JID - 101707013 PMC - PMC12723803 OTO - NOTNLM OT - X-linked hypophosphatemia (XLH) OT - hypophosphatemia OT - online calculator OT - osteomalacia OT - tubular maximum phosphate reabsorption per glomerular filtration rate COIS- C.C. received honoraria from Amgen and Specialised Therapeutics. P.C. and R.C.-B. received honoraria from Kyowa Kirin. EDAT- 2025/12/25 07:40 MHDA- 2025/12/25 07:41 PMCR- 2025/12/06 CRDT- 2025/12/25 04:48 PHST- 2024/08/28 00:00 [received] PHST- 2024/10/21 00:00 [revised] PHST- 2024/11/06 00:00 [accepted] PHST- 2025/12/25 07:41 [medline] PHST- 2025/12/25 07:40 [pubmed] PHST- 2025/12/25 04:48 [entrez] PHST- 2025/12/06 00:00 [pmc-release] AID - ziae140 [pii] AID - 10.1093/jbmrpl/ziae140 [doi] PST - epublish SO - JBMR Plus. 2025 Dec 6;9(Suppl 5):v94-v100. doi: 10.1093/jbmrpl/ziae140. eCollection 2025 Dec. PMID- 41441866 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260715 IS - 2168-6602 (Electronic) IS - 0890-1171 (Linking) VI - 40 IP - 7 DP - 2026 Sep TI - Physical Activity and Sleep as Predictors of Well-Being in Young Adults. PG - 811-819 LID - 10.1177/08901171251409404 [doi] AB - PurposeTo examine physical activity and sleep as predictors of well-being in young adults and explore differences by sex, age, and student status.Design & SettingA cross-sectional, online survey containing validated questionnaires was utilized to measure self-reported physical activity, sleep, and well-being.SampleParticipants were recruited through local and national recruitment efforts and social media. Of 329 survey respondents, 230 adults (69.9%) aged 18-25 years without current injury or physical activity limitations completed the survey between April 2020 and September 2020.MeasuresQuestionnaires utilized included the Godin Leisure Time Exercise Questionnaire for physical activity, the Pittsburgh Sleep Quality Index for sleep, and the Physical Summary Component and Mental Summary Component of the Modified Disablement in the Physically Active Scale for physical and mental well-being.AnalysisLinear regression models, Welch 2 Sample t-tests, Analysis of Variance, Tukey's Honest Significant Difference tests, chi-square tests of independence, F-tests, and stepwise AIC techniques were utilized in data analyses.ResultsSleep quality was the strongest predictor of mental and physical well-being (Estimate = 0.500, P < .001). While no differences in sleep quality or well-being were identified by sex, age, or student status, physical activity was higher among males and younger participants.ConclusionYoung adulthood is a crucial time to establish healthy physical activity and sleep patterns to promote well-being. Collection of data during the COVID pandemic may limit generalizability of results. FAU - Vanderford, Cheryl AU - Vanderford C AUID- ORCID: 0009-0002-7091-6041 AD - Physician Assistant Studies, University of Kentucky, Lexington, KY, USA. RINGGOLD: 4530 FAU - Dlugonski, Deirdre AU - Dlugonski D AD - Department of Athletic Training and Clinical Nutrition, University of Kentucky, Lexington, KY, USA. FAU - Potter, Daniel AU - Potter D AD - Physician Assistant Studies, University of Kentucky, Lexington, KY, USA. RINGGOLD: 4530 FAU - Hoch, Johanna M AU - Hoch JM AD - Department of Athletic Training and Clinical Nutrition, University of Kentucky, Lexington, KY, USA. LA - eng PT - Journal Article DEP - 20251224 PL - United States TA - Am J Health Promot JT - American journal of health promotion : AJHP JID - 8701680 SB - IM MH - Humans MH - *Exercise/psychology MH - Male MH - Young Adult MH - Female MH - Adolescent MH - Cross-Sectional Studies MH - Psychological Well-Being MH - *Sleep MH - Adult MH - *Sleep Quality MH - Surveys and Questionnaires MH - COVID-19/epidemiology MH - *Mental Health MH - Sex Factors MH - Age Factors MH - Self Report MH - Sleep Duration OTO - NOTNLM OT - age OT - mental health OT - physical activity OT - predictors of well-being OT - self-reported physical activity OT - sex OT - sleep OT - sleep quality OT - student status OT - well-being OT - young adult COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/12/24 12:55 MHDA- 2026/07/15 18:41 CRDT- 2025/12/24 10:44 PHST- 2026/07/15 18:41 [medline] PHST- 2025/12/24 12:55 [pubmed] PHST- 2025/12/24 10:44 [entrez] AID - 10.1177/08901171251409404 [doi] PST - ppublish SO - Am J Health Promot. 2026 Sep;40(7):811-819. doi: 10.1177/08901171251409404. Epub 2025 Dec 24. PMID- 41439490 OWN - NLM STAT- Publisher LR - 20251224 IS - 0975-5764 (Electronic) IS - 0975-5764 (Linking) DP - 2025 Dec 24 TI - Shaping Young Appetites: The Role of Sociodemographic, Lifestyle, and Physical Activity Factors in Food Preferences and Dietary Habits among School Children. LID - 10.4103/aam.aam_614_25 [doi] AB - CONTEXT: Food preferences and dietary habits among school children are influenced by sociodemographic, anthropometric, lifestyle, and physical activity factors. Understanding these associations is crucial for designing effective interventions to promote healthy eating habits. AIMS: This study aimed to investigate the factors such as sociodemographics, anthropometry, physical activity, and lifestyle influencing food preferences and dietary habits among school children. SETTINGS AND DESIGN: A cross-sectional study was conducted among 422 students from four schools in Mangaluru between January and December 2021. MATERIALS AND METHODS: Data on sociodemographics, anthropometry, lifestyle, physical activity, and diet were collected using a validated questionnaire. Continuous variables were expressed as medians (interquartile range) and categorical variables as frequencies. Group differences were tested with Mann-Whitney U-test and Chi-square tests. Logistic regression generated crude and adjusted odds ratios with 95% confidence intervals (CIs). Subgroup analyses explored snacking patterns. P <0.05 was considered statistically significant. RESULTS: Among participants, 44.8% had normal status, 29.9% underweight, and 25.4% overweight. Vegetable preference was lower in middle-income groups (CI = 0.282-0.764, P = 0.003) but higher for milk products in high-income (CI = 1.452-11.19, P = 0.007) and very-healthy lifestyles (CI = 0.634-5.34, P < 0.001). Moderate physical activity increased preference for vegetables (CI = 1.067-2.747, P = 0.026) and snacks (CI = 1.128-3.82, P = 0.019) with higher fruit (OR = 1.141-3.35, P = 0.015), vegetable (CI = 1.207-3.30, P = 0.007), nonvegetarian foods (CI = 1.462-3.91, P < 0.001), and milk products consumption (CI = 1.350-3.44, P = 0.001). Moderately healthy lifestyles reduced fast food preference (CI = 0.368-0.988, P = 0.045) and raised vegetable intake further in very-healthy groups (CI = 1.138-4.16, P = 0.019). Evening-snacking predominated (chi(2) =260.3, P < 0.001). Boys were more active (P = 0.014). CONCLUSIONS: Food preferences reflected actual consumption and were shaped by higher income, physical activity, and healthier lifestyles. Gender-sensitive, context-specific, targeted school, and community-based nutrition education with parental involvement can reduce future chronic-disease risk among school children. CI - Copyright (c) 2025 Annals of African Medicine. FAU - Chatterjee, Poulomi AU - Chatterjee P AD - Department of Community Medicine, Yenepoya Medical College, Yenepoya (Deemed to be University), Mangaluru, Karnataka, India. FAU - Nirgude, Abhay Subhashrao AU - Nirgude AS LA - fre LA - eng PT - Journal Article DEP - 20251224 PL - India TA - Ann Afr Med JT - Annals of African medicine JID - 101231417 SB - IM OTO - NOTNLM OT - Child OT - Enfant OT - choix alimentaires OT - comportement alimentaire OT - eating behavior OT - exercice OT - exercise OT - food selections OT - health-education OT - lifestyle OT - mode de vie OT - schools OT - ecoles OT - education pour la sante EDAT- 2025/12/24 12:55 MHDA- 2025/12/24 12:55 CRDT- 2025/12/24 06:52 PHST- 2025/10/06 00:00 [received] PHST- 2025/11/18 00:00 [accepted] PHST- 2025/12/24 12:55 [medline] PHST- 2025/12/24 12:55 [pubmed] PHST- 2025/12/24 06:52 [entrez] AID - 01244624-990000000-00464 [pii] AID - 10.4103/aam.aam_614_25 [doi] PST - aheadofprint SO - Ann Afr Med. 2025 Dec 24. doi: 10.4103/aam.aam_614_25. PMID- 41437297 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251224 LR - 20251227 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 13 IP - 1 DP - 2025 Dec 23 TI - Childhood traumatic experiences and addiction-like eating behaviors: the mediating roles of attachment, mentalization, and emotional eating. PG - 288 LID - 10.1186/s40337-025-01473-x [doi] LID - 288 AB - INTRODUCTION: Childhood traumatic experiences (CTEs) represent a significant vulnerability factor for addiction-like eating behaviors, yet the underlying developmental pathways remain poorly understood. According to infancy research and attachment theory, this study tested a comprehensive mediation model examining how CTEs contribute to addiction-like eating patterns (i.e., appetite drive and low diet control) through attachment insecurity, impaired reflective functioning, and emotional eating. METHOD: A cross-sectional study was conducted on a conventional non-clinical sample 1,014 Italian adults. Participants completed a set of validated and standardized scales. Structural equation modeling with latent variables and bootstrap resampling (10,000 iterations) was employed to test the hypothesized model. RESULTS: The model demonstrated adequate fit and supported all hypotheses. CTEs significantly predicted both attachment anxiety, attachment avoidance, and impaired reflective functioning. Attachment anxiety, but not avoidance, mediated the relationship between CTEs and impaired reflective functioning. Also, impaired reflective functioning significantly predicted emotional eating, which in turn predicted both appetite drive and low dietary control. The complete mediation pathway was statistically significant, explaining 53.5% of variance in appetite drive and 20.6% in dietary control. DISCUSSION: These findings provide the first empirical support for a trauma-based developmental model of addiction-like eating behaviors. The results highlight the central role of attachment anxiety and impaired reflective functioning in linking early relational trauma to emotional eating and food addiction-like patterns. Clinical implications suggest that mentalization-based interventions targeting attachment insecurity and emotion regulation may be particularly beneficial for individuals with trauma histories and problematic eating behaviors. CI - (c) 2025. The Author(s). FAU - Rossi, Alessandro Alberto AU - Rossi AA AUID- ORCID: 0000-0001-7000-5999 AD - Department of Philosophy, Sociology, Education, and Applied Psychology, Section of Applied Psychology, University of Padova, Padova, Italy. a.rossi@unipd.it. AD - Center for Intervention and Research on Family Studies-CIRF-Department of Philosophy, Sociology, Education, and Applied Psychology, Section of Applied Psychology, University of Padova, Padova, Italy. a.rossi@unipd.it. FAU - Mannarini, Stefania AU - Mannarini S AUID- ORCID: 0000-0002-8446-785X AD - Department of Philosophy, Sociology, Education, and Applied Psychology, Section of Applied Psychology, University of Padova, Padova, Italy. AD - Center for Intervention and Research on Family Studies-CIRF-Department of Philosophy, Sociology, Education, and Applied Psychology, Section of Applied Psychology, University of Padova, Padova, Italy. LA - eng PT - Journal Article DEP - 20251223 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC12723922 OAB - People who experienced difficult or harmful relationships with caregivers during childhood, such as abuse or neglect, are more likely to develop unhealthy eating patterns that resemble addiction. This study explored how this happens. We surveyed over 1,000 Italian adults and found that childhood trauma creates a chain reaction. First, these early negative experiences often lead people to feel anxious in their relationships and struggle to understand their own emotions and those of others. When people cannot recognize or manage their feelings well, they may turn to food for comfort, eating to cope with stress rather than hunger. Over time, this emotional eating can develop into addiction-like behaviors, including intense cravings for certain foods and difficulty controlling how much they eat. Our findings suggest that treating problematic eating patterns requires addressing more than just food and diet. Therapies that help people better understand their emotions, improve their relationships, and develop healthier ways to manage stress may be especially helpful for those who experienced childhood trauma. Understanding these connections can lead to more effective support for people struggling with food-related difficulties. OABL- eng OTO - NOTNLM OT - Addiction-like eating behaviors OT - Attachment anxiety OT - Childhood traumatic experiences OT - Eating addiction OT - Food addiction OT - Low diet control OT - Mentalization COIS- Declarations. Ethics approval and consent to participate: Ethics approval was provided by the Ethics Committee of the University of Padua (n degrees 547-a). Informed consent was obtained from all participants. All procedures adhered to the relevant guidelines and regulations. The study described has been carried out in accordance with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/24 07:43 MHDA- 2025/12/24 07:44 PMCR- 2025/12/23 CRDT- 2025/12/24 00:29 PHST- 2025/08/08 00:00 [received] PHST- 2025/11/16 00:00 [accepted] PHST- 2025/12/24 07:44 [medline] PHST- 2025/12/24 07:43 [pubmed] PHST- 2025/12/24 00:29 [entrez] PHST- 2025/12/23 00:00 [pmc-release] AID - 10.1186/s40337-025-01473-x [pii] AID - 1473 [pii] AID - 10.1186/s40337-025-01473-x [doi] PST - epublish SO - J Eat Disord. 2025 Dec 23;13(1):288. doi: 10.1186/s40337-025-01473-x. PMID- 41435761 OWN - NLM STAT- MEDLINE DCOM- 20260503 LR - 20260605 IS - 1536-4844 (Electronic) IS - 1078-0998 (Linking) VI - 32 IP - 5 DP - 2026 May 1 TI - Tonsillectomy and the Risk of Inflammatory Bowel Disease: A Retrospective Cohort Study Using Real-World US Data. PG - 884-892 LID - 10.1093/ibd/izaf306 [doi] AB - IMPORTANCE: Inflammatory bowel disease (IBD) encompasses chronic inflammatory conditions primarily affecting the small intestine and colon. Ulcerative colitis (UC) and Crohn's disease (CD) involve dysregulated immune responses to intestinal microbiota, influenced by genetic predisposition, environmental factors, and gut barrier dysfunction. This retrospective cohort study was carried out to understand the relationship between immune-modulating surgeries like tonsillectomy and the development of IBD. OBJECTIVE: To evaluate the association between tonsillectomy and the risk of developing IBD. Design, Setting, and Participants: This retrospective cohort study used the TriNetX research network, a large US-based collaborative platform, to identify 124,132,724 individuals from 2005 to 2023. After applying inclusion criteria, 1,420,302 matched participants (tonsillectomy vs nontonsillectomy) were selected using 1:1 propensity score matching. EXPOSURE: Tonsillectomy. MAIN OUTCOME AND MEASURE: The primary outcome was the incidence of IBD, including CD and UC, defined by validated diagnostic codes. Propensity score matching (PSM) (1:1) was used matching age, sex, race, body mass index, socioeconomic status, healthcare utilization, comorbidities, medications, and Creactive protein levels. Subgroup and sensitivity analyses were conducted to estimate the adjusted hazard ratio (HR) between surgical intervention and IBD risk. RESULTS: After matching, baseline characteristics were well balanced between surgical and nonsurgical groups. Tonsillectomy was associated with a significantly increased risk of developing IBD (HR, 1.30; 95% CI, 1.14-1.47). Elevated risks were observed for both CD (HR, 1.37) and UC (HR, 1.29). Increased IBD risk was consistent across demographic subgroups. Sensitivity analyses confirmed the robustness of these findings across varying follow-up periods. CONCLUSIONS AND RELEVANCE: This study highlights a significant association between tonsillectomy and increased risk of developing IBD. These observations underscore the potential role of tonsillectomy in influencing long-term gastrointestinal health, warranting further investigation into underlying mechanisms and preventative strategies. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Guo, Jyun-Yi AU - Guo JY AUID- ORCID: 0009-0007-0021-6521 AD - Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan. AD - Division of Pediatric Gastroenterology, Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan. FAU - Wu, Meng-Che AU - Wu MC AD - Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan. AD - Division of Pediatric Gastroenterology, Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan. AD - Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan. AD - School of Medicine, Chung Shan Medical University, Taichung, Taiwan. FAU - Wang, Yu-Hsun AU - Wang YH AD - Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan. FAU - Lin, Chieh-Chung AU - Lin CC AD - Division of Pediatric Gastroenterology, Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan. AD - Institute of Medicine, College of Medicine, Chung Shan Medical University, Taichung, Taiwan. FAU - Wei, James Cheng-Chung AU - Wei JC AUID- ORCID: 0000-0002-1235-0679 AD - Institute of Medicine, College of Medicine, Chung Shan Medical University, Taichung, Taiwan. AD - Department of Allergy, Immunology & Rheumatology, Chung Shan Medical University Hospital, Taichung, Taiwan. AD - Office of Research and Development, Asia University, Taichung, Taiwan. AD - Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan. LA - eng PT - Journal Article PL - England TA - Inflamm Bowel Dis JT - Inflammatory bowel diseases JID - 9508162 SB - IM MH - Humans MH - *Tonsillectomy/adverse effects/statistics & numerical data MH - Retrospective Studies MH - Male MH - Female MH - Adult MH - United States/epidemiology MH - Risk Factors MH - Middle Aged MH - Incidence MH - *Crohn Disease/epidemiology/etiology MH - *Colitis, Ulcerative/epidemiology/etiology MH - *Inflammatory Bowel Diseases/epidemiology/etiology MH - Propensity Score MH - Young Adult MH - Adolescent MH - Follow-Up Studies OAB - Tonsillectomy is associated with a significantly increased risk of developing inflammatory bowel disease, including Crohn's disease and ulcerative colitis. This large cohort study highlights the potential long-term gastrointestinal impact of immune-modulating surgeries like tonsillectomy. OABL- eng OTO - NOTNLM OT - Crohn's disease OT - inflammatory bowel disease OT - tonsillectomy OT - ulcerative colitis EDAT- 2025/12/24 00:33 MHDA- 2026/05/04 00:31 CRDT- 2025/12/23 18:12 PHST- 2025/04/15 00:00 [received] PHST- 2025/11/15 00:00 [accepted] PHST- 2026/05/04 00:31 [medline] PHST- 2025/12/24 00:33 [pubmed] PHST- 2025/12/23 18:12 [entrez] AID - 8403444 [pii] AID - 10.1093/ibd/izaf306 [doi] PST - ppublish SO - Inflamm Bowel Dis. 2026 May 1;32(5):884-892. doi: 10.1093/ibd/izaf306. PMID- 41435525 OWN - NLM STAT- MEDLINE DCOM- 20260126 LR - 20260126 IS - 1873-264X (Electronic) IS - 0731-7085 (Linking) VI - 271 DP - 2026 Apr 15 TI - Development and validation of a rapid LC-MS/MS method for methylphenidate, atomoxetine, and their metabolites with application to pediatric pharmacokinetics. PG - 117321 LID - S0731-7085(25)00662-4 [pii] LID - 10.1016/j.jpba.2025.117321 [doi] AB - Therapeutic drug monitoring of attention-deficit/hyperactivity disorder (ADHD) pharmacotherapy is challenged by substantial interindividual variability and the lack of rapid, multiplex analytical platforms. We developed and validated a fast, integrated 5-minute LC-MS/MS assay for the simultaneous quantification of stimulant (methylphenidate, ritalinic acid) and non-stimulant (atomoxetine, 4-hydroxy-atomoxetine) ADHD medications in human serum. The method employs a single-step protein precipitation and requires only 200 microL of serum. Validation demonstrated excellent linearity, precision, accuracy, minimal matrix effects, and robust analyte stability in accordance with FDA and CLSI guidelines. Application to pediatric ADHD patients revealed formulation- and dose-dependent concentration differences for methylphenidate and atomoxetine, along with strong parent-metabolite correlations. No significant associations were observed with age, sex, or body mass index. This rapid and reliable LC-MS/MS platform supports clinically actionable therapeutic drug monitoring and provides a practical framework for personalized ADHD treatment. CI - Copyright (c) 2025. Published by Elsevier B.V. FAU - Eryavuz Onmaz, Duygu AU - Eryavuz Onmaz D AD - Department of Biochemistry, Bandirma Onyedi Eylul University Faculty of Medicine, Bandirma, Turkey. Electronic address: donmaz@bandirma.edu.tr. FAU - Kuz, Merve AU - Kuz M AD - Department of Child and Adolescent Psychiatry, Diamind Mental Academy, Konya, Turkey. FAU - Cetin, Fatih Hilmi AU - Cetin FH AD - Department of Child and Adolescent Psychiatry, Diamind Mental Academy, Konya, Turkey. FAU - Ucar, Halit Necmi AU - Ucar HN AD - Department of Child and Adolescent Psychiatry, Diamind Mental Academy, Konya, Turkey. FAU - Turkoglu, Serhat AU - Turkoglu S AD - Department of Child and Adolescent Psychiatry, Selcuk University Faculty of Medicine, Konya, Turkey. FAU - Coban, Rabia AU - Coban R AD - Department of Biochemistry, Selcuk University Faculty of Medicine, Konya, Turkey. FAU - Unlu, Ali AU - Unlu A AD - Department of Biochemistry, Selcuk University Faculty of Medicine, Konya, Turkey. LA - eng PT - Journal Article PT - Validation Study DEP - 20251219 PL - England TA - J Pharm Biomed Anal JT - Journal of pharmaceutical and biomedical analysis JID - 8309336 RN - 207ZZ9QZ49 (Methylphenidate) RN - 57WVB6I2W0 (Atomoxetine Hydrochloride) RN - 0 (Central Nervous System Stimulants) SB - IM MH - *Methylphenidate/pharmacokinetics/blood MH - Humans MH - *Atomoxetine Hydrochloride/pharmacokinetics/blood/metabolism MH - *Tandem Mass Spectrometry/methods MH - Attention Deficit Disorder with Hyperactivity/drug therapy/blood MH - Child MH - Drug Monitoring/methods MH - Male MH - *Central Nervous System Stimulants/pharmacokinetics/blood MH - Female MH - Chromatography, Liquid/methods MH - Reproducibility of Results MH - Adolescent MH - Liquid Chromatography-Mass Spectrometry OTO - NOTNLM OT - Atomoxetine OT - LC-MS/MS OT - Methylphenidate OT - Pediatric ADHD OT - Pharmacokinetics OT - Therapeutic drug monitoring COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/12/24 00:34 MHDA- 2026/01/27 00:52 CRDT- 2025/12/23 18:03 PHST- 2025/11/05 00:00 [received] PHST- 2025/12/12 00:00 [revised] PHST- 2025/12/19 00:00 [accepted] PHST- 2026/01/27 00:52 [medline] PHST- 2025/12/24 00:34 [pubmed] PHST- 2025/12/23 18:03 [entrez] AID - S0731-7085(25)00662-4 [pii] AID - 10.1016/j.jpba.2025.117321 [doi] PST - ppublish SO - J Pharm Biomed Anal. 2026 Apr 15;271:117321. doi: 10.1016/j.jpba.2025.117321. Epub 2025 Dec 19. PMID- 41432743 OWN - NLM STAT- MEDLINE DCOM- 20260306 LR - 20261009 IS - 1432-1998 (Electronic) IS - 0301-0449 (Linking) VI - 56 IP - 3 DP - 2026 Mar TI - Exploring the association between BMI and liver fat in children: a study using ultrasound-derived fat fraction (UDFF). PG - 575-581 LID - 10.1007/s00247-025-06493-y [doi] AB - BACKGROUND: Childhood obesity is rising worldwide, leading to an increased prevalence of metabolic dysfunction-associated steatotic liver disease, the most common pediatric liver disease. Ultrasound-derived fat fraction (UDFF) is a recently developed technique for quantifying hepatic fat that has been validated in children, providing a rapid, reliable, and non-invasive alternative to conventional imaging. OBJECTIVE: To evaluate the association between weight status, expressed as body mass index (BMI) z-score, and UDFF in a pediatric population without underlying liver disease. MATERIALS AND METHODS: Abdominal ultrasounds including a UDFF measurement in patients without liver disease were retrospectively evaluated. We calculated the BMI z-score for all patients and classified them as normal weight (zBMI) or overweight (zBMI>/=1). UDFF values were compared across zBMI categories, sex and ethnicity (Hispanic/Latino or non-Hispanic/non-Latino), using chi-square tests (P<0.05). Pearson's correlation was used to assess the relationship between continuous UDFF values and zBMI. Logistic regression analyses were performed to assess associations between elevated UDFF (>6%) and adiposity markers (zBMI and ultrasound-measured abdominal wall thickness (AWT)), as well as ethnicity. RESULTS: Of 223 subjects, 93 (41 males/52 females, mean age of 8.2 years) met the inclusion criteria. In the normal-weight population (n=46), 41 (89.1%) had normal UDFF, and 5 (10.9%) had elevated UDFF. In the overweight group (n =47), 29 (61.7%) had normal UDFF and 18 (38.3%) had elevated UDFF. UDFF values showed a positive correlation with zBMI, and higher zBMI increased the odds of elevated UDFF. In the multivariable model including zBMI, AWT, and ethnicity, ultrasound-measured abdominal wall thickness was the strongest predictor of elevated UDFF. CONCLUSION: BMI z-score was positively associated with hepatic fat content and with higher odds of elevated UDFF. When multiple factors were considered together, ultrasound-measured abdominal wall thickness showed the strongest independent association with elevated UDFF supporting the central role of adiposity in pediatric hepatic fat accumulation. UDFF may serve as a valuable complement to routine clinical markers, using zBMI, for early identification of children with hepatic steatosis. Larger prospective studies are needed to define its role in clinical practice. CI - (c) 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Moeremans, Marine AU - Moeremans M AD - Department of Pediatric Radiology, Stanford University, Lucile Packard Children's Hospital, 725 Welch Rd, Palo Alto, CA 94304, USA. marine.moeremans@hotmail.com. FAU - Barth, Richard A AU - Barth RA AD - Department of Pediatric Radiology, Stanford University, Lucile Packard Children's Hospital, 725 Welch Rd, Palo Alto, CA 94304, USA. FAU - Zalcman, Max AU - Zalcman M AD - Department of Pediatric Radiology, Queen Fabiola Children's University Hospital, Brussels, Belgium. FAU - Rubesova, Erika AU - Rubesova E AD - Department of Pediatric Radiology, Stanford University, Lucile Packard Children's Hospital, 725 Welch Rd, Palo Alto, CA 94304, USA. rubesova@stanford.edu. LA - eng PT - Journal Article DEP - 20251223 PL - Germany TA - Pediatr Radiol JT - Pediatric radiology JID - 0365332 SB - IM MH - Humans MH - Female MH - Male MH - Child MH - Ultrasonography/methods MH - *Body Mass Index MH - Retrospective Studies MH - *Pediatric Obesity/diagnostic imaging MH - Adolescent MH - Child, Preschool MH - *Liver/diagnostic imaging MH - *Fatty Liver/diagnostic imaging MH - *Adipose Tissue/diagnostic imaging OTO - NOTNLM OT - Childhood obesity OT - Steatosis OT - UDFF COIS- Declarations. Conflicts of interest: The authors declare no competing interests. EDAT- 2025/12/23 12:47 MHDA- 2026/03/07 01:37 CRDT- 2025/12/23 11:13 PHST- 2025/08/30 00:00 [received] PHST- 2025/12/02 00:00 [accepted] PHST- 2025/11/30 00:00 [revised] PHST- 2026/03/07 01:37 [medline] PHST- 2025/12/23 12:47 [pubmed] PHST- 2025/12/23 11:13 [entrez] AID - 10.1007/s00247-025-06493-y [pii] AID - 10.1007/s00247-025-06493-y [doi] PST - ppublish SO - Pediatr Radiol. 2026 Mar;56(3):575-581. doi: 10.1007/s00247-025-06493-y. Epub 2025 Dec 23. PMID- 41432100 OWN - NLM STAT- MEDLINE DCOM- 20260307 LR - 20260813 IS - 1536-4801 (Electronic) IS - 0277-2116 (Print) IS - 0277-2116 (Linking) VI - 82 IP - 3 DP - 2026 Mar TI - Fatigue in pediatric inflammatory bowel disease: Explained by transdiagnostic and disease-focused factors. PG - 699-707 LID - 10.1002/jpn3.70317 [doi] AB - OBJECTIVE: Fatigue is highly prevalent in children with inflammatory bowel disease (IBD), even during clinical remission. This suggests a role for transdiagnostic factors-lifestyle, psychological, and social influences not specific to the disease. This study aimed to assess the prevalence of severe fatigue in pediatric IBD and evaluate its associations with both IBD-focused and transdiagnostic factors. METHODS: Children with IBD ages 8-18 from the PROactive cohort completed the Pediatric Quality of Life Inventory-Multidimensional Fatigue Scale. IBD-focused clinical data were extracted from electronic health records. Transdiagnostic factors were assessed using validated patient-reported outcome measures. Associations with fatigue were examined using linear regression. RESULTS: Among 127 patients (mean age 14.9 +/- 2.7 years; 43% male), most were in clinical remission. One hundred six patients self-reported fatigue, and 99 parents reported their child's fatigue. Severe fatigue was self-reported by 29%. Of IBD-focused factors, only disease activity (beta = -0.40) and comorbidity (beta = -0.18) showed significant associations with fatigue. Of transdiagnostic factors, lower physical, emotional, and social functioning; poorer sleep quality; less physical activity; more pain, anxiety, and depressive symptoms; lower life satisfaction and self-rated health; and increased school absence and pressure were significantly associated with more fatigue. Backward selection retained only transdiagnostic factors in the multivariate model, which explained 78% of fatigue variance. CONCLUSION: Fatigue is common in children with IBD and is more strongly associated with transdiagnostic than disease-focused factors. These findings highlight the importance of integrative care strategies that address modifiable psychosocial and lifestyle domains to reduce fatigue and improve functioning in children with IBD. CI - (c) 2025 The Author(s). Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Stutvoet, Maartje D AU - Stutvoet MD AUID- ORCID: 0000-0002-8857-7749 AD - Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. FAU - Vroegindeweij, Anouk AU - Vroegindeweij A AD - Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. FAU - Toonen, Tessa Z AU - Toonen TZ AD - Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands. FAU - Nap-Van der Vlist, Merel M AU - Nap-Van der Vlist MM AD - Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. FAU - Hoefnagels, Johanna W AU - Hoefnagels JW AD - Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. FAU - van den Berg, Anemone AU - van den Berg A AD - Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands. FAU - Nijhof, Sanne L AU - Nijhof SL AD - Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. LA - eng GR - NWA.1292.19.226/Netherlands Organization for Scientific Research under the eHealth Junior consortium project/ PT - Journal Article DEP - 20251223 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM MH - Humans MH - Male MH - *Fatigue/epidemiology/etiology/psychology/diagnosis MH - Female MH - Child MH - Adolescent MH - *Inflammatory Bowel Diseases/complications/psychology MH - Quality of Life MH - Prevalence MH - Severity of Illness Index MH - Patient Reported Outcome Measures MH - Self Report PMC - PMC12964513 OTO - NOTNLM OT - Crohn's disease OT - child health OT - cohort studies OT - disease activity OT - ulcerative colitis COIS- The authors declare no conflicts of interest. EDAT- 2025/12/23 12:48 MHDA- 2026/03/07 16:11 PMCR- 2026/03/06 CRDT- 2025/12/23 06:13 PHST- 2025/11/18 00:00 [revised] PHST- 2025/07/22 00:00 [received] PHST- 2025/11/21 00:00 [accepted] PHST- 2026/03/07 16:11 [medline] PHST- 2025/12/23 12:48 [pubmed] PHST- 2025/12/23 06:13 [entrez] PHST- 2026/03/06 00:00 [pmc-release] AID - JPN370317 [pii] AID - 10.1002/jpn3.70317 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2026 Mar;82(3):699-707. doi: 10.1002/jpn3.70317. Epub 2025 Dec 23. PMID- 41432023 OWN - NLM STAT- MEDLINE DCOM- 20260528 LR - 20260528 IS - 1553-3514 (Electronic) IS - 1553-3506 (Linking) VI - 33 IP - 3 DP - 2026 Jun TI - Artificial Intelligence-Based Prediction of Recurrence and Personalized Treatment Planning in Pediatric Pilonidal Sinus Disease. PG - 225-233 LID - 10.1177/15533506251411009 [doi] AB - PurposeThis study aimed to assess the feasibility of artificial intelligence (AI)-based models for predicting recurrence risk and supporting individualized treatment strategies in pediatric pilonidal sinus disease (PSD).MethodsClinical data from 242 pediatric PSD patients were retrospectively analyzed. Two machine learning (ML) models were developed: (1) a binary classifier for recurrence prediction and (2) a multiclass classifier for treatment modality selection. Model performance was evaluated using 5-fold cross-validation based on accuracy, area under the receiver operating characteristic curve (ROC-AUC), F1 score, and confusion matrix. Model interpretability was assessed using SHapley Additive exPlanations (SHAP) analysis to identify the most influential predictive features.ResultsAmong 242 patients, 59.1% underwent surgical excision (unroofing with secondary healing), 33.1% received crystallized phenol, and 7.8% were treated with silver nitrate. The overall recurrence rate was 5.7%, with no significant differences among treatment modalities. Longer healing duration, larger lesion size, higher body mass index (BMI), and an increased number of sinus tracts were associated with higher recurrence risk. SHAP analysis revealed that healing time, BMI, age, and the number of sinus tracts were the most influential predictors in both recurrence and treatment selection models.ConclusionAI-based predictive models can effectively estimate recurrence risk and assist in tailoring individualized management strategies for pediatric PSD. Further multicenter, prospective studies are warranted to validate these findings and support clinical integration of AI-assisted decision systems. FAU - Oztas, Tulin AU - Oztas T AUID- ORCID: 0000-0002-1010-3324 AD - Department of Pediatric Surgery, University of Health Sciences Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey. FAU - Cal, Suat AU - Cal S AD - Department of Pediatric Surgery, University of Health Sciences Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey. FAU - Akdeniz, Sevinc AU - Akdeniz S AD - Department of Pediatric Surgery, University of Health Sciences Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey. FAU - Tegin, Serdest AU - Tegin S AD - Department of Pediatric Surgery, University of Health Sciences Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20251223 PL - United States TA - Surg Innov JT - Surgical innovation JID - 101233809 RN - 95IT3W8JZE (Silver Nitrate) RN - 339NCG44TV (Phenol) RN - 0 (Sclerosing Solutions) SB - IM MH - Risk Assessment/methods MH - *Pilonidal Sinus/drug therapy/epidemiology/surgery MH - Recurrence MH - Feasibility Studies MH - ROC Curve MH - Silver Nitrate/administration & dosage MH - Phenol/administration & dosage MH - Sclerosing Solutions/administration & dosage MH - Risk Factors MH - *Clinical Decision-Making/methods MH - Retrospective Studies MH - Time Factors MH - Age Factors MH - Body Mass Index MH - Cross-Sectional Studies MH - Follow-Up Studies MH - *Machine Learning MH - Random Forest MH - Boosting Machine Learning Algorithms MH - Humans MH - Male MH - Female MH - Child MH - Adolescent OTO - NOTNLM OT - artificial intelligence OT - machine learning OT - personalized treatment OT - pilonidal sinus disease OT - recurrence prediction COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/12/23 07:47 MHDA- 2026/05/25 06:31 CRDT- 2025/12/23 05:42 PHST- 2026/05/25 06:31 [medline] PHST- 2025/12/23 07:47 [pubmed] PHST- 2025/12/23 05:42 [entrez] AID - 10.1177/15533506251411009 [doi] PST - ppublish SO - Surg Innov. 2026 Jun;33(3):225-233. doi: 10.1177/15533506251411009. Epub 2025 Dec 23. PMID- 41431034 OWN - NLM STAT- MEDLINE DCOM- 20251223 LR - 20260523 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 104 IP - 51 DP - 2025 Dec 19 TI - A nomogram to predict large-for-gestational-age in term newborns: A retrospective single-center study. PG - e46580 LID - 10.1097/MD.0000000000046580 [doi] LID - e46580 AB - This study aims to build and validate a nomogram for large-for-gestational-age (LGA) prediction in full-term (37-41 weeks of gestation) newborns. This retrospective single-center study included consecutive full-term deliveries (37-41 weeks' gestation) at Yuyao People's Hospital of Zhejiang Province from January to December 2021. Participants were randomly assigned (7:3) to training and validation sets. The current study included 1481 deliveries (training n = 1017; validation n = 464). Gestational age (odds ratio [OR] = 1.32, 95% confidence interval [CI]: 1.13-1.54), gestational weight gain (OR = 1.07, 95% CI: 1.03-1.12), symphysis-fundal height (OR = 1.14, 95% CI: 1.03-1.27), fetal abdominal circumference (OR = 1.10, 95% CI: 1.09-1.12), triglycerides (OR = 1.49, 95% CI: 1.08-2.05), gestational diabetes mellitus (OR = 2.05, 95% CI: 1.33-3.14), and pre-pregnancy body mass index < 18.5 (OR = 0.48, 95% CI: 0.28-0.81) had independent associations with LGA. A nomogram was developed, and receiver operating characteristic curves had areas under the curves of 0.846 (95% CI: 0.821-0.871) and 0.802 (95% CI: 0.761-0.842) in the training and validation sets, respectively. Seven factors were independently associated with LGA. A nomogram was developed and showed favorable predictive performance. CI - Copyright (c) 2025 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Wu, Yingyun AU - Wu Y AD - Department of Obstetrics and Gynecology, The Affiliated Yangming Hospital of Ningbo University (Yuyao People's Hospital of Zhejiang Province), Yuyao, China. FAU - Ma, Jianting AU - Ma J AUID- ORCID: 0000-0003-4978-7337 LA - eng GR - No. 2021KY1073/Medical and Health Science and Technology Planned Project of Zhejiang Province/ PT - Journal Article PT - Observational Study PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - *Nomograms MH - Retrospective Studies MH - Female MH - Infant, Newborn MH - Pregnancy MH - Gestational Age MH - Male MH - Adult MH - *Birth Weight MH - *Fetal Macrosomia/diagnosis/epidemiology MH - China/epidemiology MH - ROC Curve MH - Body Mass Index MH - Gestational Weight Gain PMC - PMC12727380 OTO - NOTNLM OT - large-for-gestational-age OT - newborn OT - nomogram OT - risk factor COIS- The authors have no conflicts of interest to disclose. EDAT- 2025/12/23 07:47 MHDA- 2025/12/23 07:48 PMCR- 2025/12/19 CRDT- 2025/12/23 01:04 PHST- 2024/12/20 00:00 [received] PHST- 2025/10/27 00:00 [accepted] PHST- 2025/12/23 07:48 [medline] PHST- 2025/12/23 07:47 [pubmed] PHST- 2025/12/23 01:04 [entrez] PHST- 2025/12/19 00:00 [pmc-release] AID - 00005792-202512190-00075 [pii] AID - MD-D-24-16297 [pii] AID - 10.1097/MD.0000000000046580 [doi] PST - ppublish SO - Medicine (Baltimore). 2025 Dec 19;104(51):e46580. doi: 10.1097/MD.0000000000046580. PMID- 41430208 OWN - NLM STAT- MEDLINE DCOM- 20251230 LR - 20260101 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Dec 22 TI - Physical activity barriers, nutrition, motivation, and body composition in university students. PG - 4307 LID - 10.1186/s12889-025-26048-y [doi] LID - 4307 AB - BACKGROUND: Young adulthood is a period in which long-term lifestyle patterns are established. Barriers such as time constraints, low motivation, and environmental limitations may reduce participation in physical activity and hinder healthy nutritional behaviours. This study examined the relationships among nutritional attitudes, barriers to physical activity, general motivation, and body composition in university students. METHOD: A cross-sectional design was used with 600 students (M = 21.08 +/- 1.85(years); 50% women). Nutritional attitudes, physical activity barriers, and general motivation were assessed using validated scales, and body composition was measured using bioelectrical impedance analysis. Analyses included t-tests, correlations, and multiple regression. Regression models were structured to examine how nutritional attitudes and general motivation relate to perceived barriers, aligning the analytical approach with the theoretical framework. Regression assumptions and sampling procedures were checked prior to analysis. RESULTS: Students showed moderately positive nutritional attitudes (M = 40.53) and perceived personal factors as the most prominent barriers (M = 30.19). Men scored higher in nutritional attitudes, whereas women reported higher barrier perceptions and higher general motivation levels. Nutritional attitudes were negatively associated with barriers (r = -.332), and general motivation showed a weaker but significant negative association (r = -.189). Nutritional attitudes predicted 11% of the variance in barriers (R(2) = 0.110), increasing to 12.5% when general motivation was included. Positive nutritional attitudes were associated with higher muscle mass (beta = 0.270) and lower fat percentage (beta = -0.156), while barrier perceptions showed the opposite pattern. The negative association between barriers and all motivation subscales (including amotivation) indicates that higher barriers correspond to lower overall motivational engagement rather than increased amotivation. CONCLUSION: Integrating behavioural scales with body composition measures shows that nutritional attitudes, general motivation, and perceived barriers jointly shape students' healthy lifestyle profiles. These findings can inform gender-sensitive, university-based health promotion programs designed to reduce barriers and strengthen students' overall motivational regulation. CI - (c) 2025. The Author(s). FAU - Akil, Mustafa AU - Akil M AUID- ORCID: 0000-0003-1161-9231 AD - Faculty of Sport Sciences, University of Usak, Usak, Turkiye. mustafa.akil@usak.edu.tr. FAU - Tokay, Bekir AU - Tokay B AUID- ORCID: 0000-0003-0059-0736 AD - Faculty of Sport Sciences, University of Usak, Usak, Turkiye. FAU - Gungor, Melek Gulem AU - Gungor MG AUID- ORCID: 0000-0003-1928-6304 AD - Faculty of Sport Sciences, University of Usak, Usak, Turkiye. LA - eng PT - Journal Article DEP - 20251222 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - Male MH - *Motivation MH - *Students/psychology/statistics & numerical data MH - Cross-Sectional Studies MH - Universities MH - *Body Composition MH - Young Adult MH - *Exercise/psychology MH - Adult MH - *Nutritional Status MH - Surveys and Questionnaires MH - Adolescent PMC - PMC12752208 OTO - NOTNLM OT - Barriers to physical activity OT - Body composition OT - Motivation OT - Nutritional attitudes OT - University students COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the ethical standards of the Declaration of Helsinki. Ethical approval was obtained from the Ethics Committee of Usak University (E. E.287026; Decision No: 2025 - 193). All participants were informed about the research procedures and provided written informed consent prior to participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/23 00:27 MHDA- 2025/12/30 07:41 PMCR- 2025/12/22 CRDT- 2025/12/22 23:37 PHST- 2025/09/08 00:00 [received] PHST- 2025/12/17 00:00 [accepted] PHST- 2025/12/30 07:41 [medline] PHST- 2025/12/23 00:27 [pubmed] PHST- 2025/12/22 23:37 [entrez] PHST- 2025/12/22 00:00 [pmc-release] AID - 10.1186/s12889-025-26048-y [pii] AID - 26048 [pii] AID - 10.1186/s12889-025-26048-y [doi] PST - epublish SO - BMC Public Health. 2025 Dec 22;25(1):4307. doi: 10.1186/s12889-025-26048-y. PMID- 41429978 OWN - NLM STAT- MEDLINE DCOM- 20260308 LR - 20260813 IS - 1476-5497 (Electronic) IS - 0307-0565 (Print) IS - 0307-0565 (Linking) VI - 50 IP - 3 DP - 2026 Mar TI - Infant social withdrawal and rapid infant weight gain. PG - 671-678 LID - 10.1038/s41366-025-01996-y [doi] AB - BACKGROUND: Rapid infant weight gain (RIWG) and infant social withdrawal are important early markers of risk of subsequent overweight/obesity and mental health problems, respectively. While overweight and mental health problems are linked later in life, it remains unclear if this association is present already in infancy. OBJECTIVE: We examine if infant social withdrawal is associated with subsequent RIWG independently of an array of known risk factors (gestational age, birth weight, sex, parity, breastfeeding, maternal postpartum depressive symptoms, maternal smoking during pregnancy, maternal age at birth and pre-pregnancy BMI, family educational level, and employment status). METHODS: In a cohort of 12,468 children born 2015-19 in Copenhagen, we analyzed the association between infant social withdrawal around age 3 months, measured with the Alarm Distress Baby Scale (ADBB)-a validated screening tool, and subsequent RIWG. We retrieved information on social withdrawal and weight during infancy from health visitors' records and linked these to register data. Multivariate logistic regression was used to estimate adjusted odds ratios (aOR) and 95% confidence intervals (CI) for RIWG, adjusting for the known risk factors outlined above. RESULTS: Children showing signs of social withdrawal had 1.19 higher odds of RIWG compared to children showing no signs of social withdrawal (aOR 1.19; 95% CI: 1.03, 1.37, p = 0.017). RIWG was also more likely among boys, firstborns, children born small-for-gestational age, and those with mothers who smoked during pregnancy or had higher pre-pregnancy BMI. In contrast, higher birth weight and breastfeeding >4 months were protective factors. No associations were found with maternal postpartum depression, low education, parental labor market status, or maternal age. CONCLUSIONS: We found an association between infant social withdrawal and subsequent rapid infant weight gain independently of an array of known risk factors, which may expand our understanding of the developmental origins of excess weight gain and its association with early childhood mental health. CI - (c) 2025. The Author(s). FAU - Sander, Sarah AU - Sander S AUID- ORCID: 0000-0002-1917-0304 AD - Centre of Excellence in Early Intervention and Family Studies, Department of Psychology, University of Copenhagen, Copenhagen, Denmark. FAU - Stuart, Anne Christine AU - Stuart AC AUID- ORCID: 0000-0003-3829-9995 AD - Centre of Excellence in Early Intervention and Family Studies, Department of Psychology, University of Copenhagen, Copenhagen, Denmark. ach@psy.ku.dk. FAU - Stougaard, Maria AU - Stougaard M AD - Steno Diabetes Center Copenhagen, Herlev, Denmark. FAU - Sorensen, Thorkild I A AU - Sorensen TIA AUID- ORCID: 0000-0003-4821-430X AD - Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. AD - NNF Centre for Basic Metabolic Health, University of Copenhagen, Copenhagen, Denmark. FAU - Mohr, Julie Elisabeth Warberg AU - Mohr JEW AUID- ORCID: 0000-0002-0545-4584 AD - Centre of Excellence in Early Intervention and Family Studies, Department of Psychology, University of Copenhagen, Copenhagen, Denmark. FAU - Vaever, Mette Skovgaard AU - Vaever MS AD - Centre of Excellence in Early Intervention and Family Studies, Department of Psychology, University of Copenhagen, Copenhagen, Denmark. AD - National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251222 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 SB - IM MH - Humans MH - Female MH - *Weight Gain/physiology MH - Infant MH - Male MH - Risk Factors MH - Denmark/epidemiology MH - Pregnancy MH - Adult MH - Infant, Newborn MH - Pediatric Obesity/epidemiology MH - Cohort Studies MH - *Social Isolation/psychology MH - Body Mass Index PMC - PMC12965871 COIS- Competing interests: SS, ACS, JEWM and MSV are employed at the Centre of Excellence in Early Intervention and Family Studies where training in the use of the ADBB scale is offered as part of the continuing education program at the University of Copenhagen. Ethics approval and consent to participate: Under Danish law, research projects based solely on existing register data do not require individual informed consent. The DAIC project, of which the current study is a subproject, was approved by the ethics committee at the Department of Psychology, University of Copenhagen (ref number: IP-EC-08042025-1). EDAT- 2025/12/23 00:27 MHDA- 2026/03/08 01:38 PMCR- 2025/12/22 CRDT- 2025/12/22 23:25 PHST- 2025/04/09 00:00 [received] PHST- 2025/12/05 00:00 [accepted] PHST- 2025/10/29 00:00 [revised] PHST- 2026/03/08 01:38 [medline] PHST- 2025/12/23 00:27 [pubmed] PHST- 2025/12/22 23:25 [entrez] PHST- 2025/12/22 00:00 [pmc-release] AID - 10.1038/s41366-025-01996-y [pii] AID - 1996 [pii] AID - 10.1038/s41366-025-01996-y [doi] PST - ppublish SO - Int J Obes (Lond). 2026 Mar;50(3):671-678. doi: 10.1038/s41366-025-01996-y. Epub 2025 Dec 22. PMID- 41428420 OWN - NLM STAT- MEDLINE DCOM- 20260801 LR - 20260805 IS - 1708-8283 (Electronic) IS - 0883-0738 (Linking) VI - 41 IP - 8 DP - 2026 Sep TI - Sleep and Fatigue in Children and Adolescents With Multiple Sclerosis. PG - 1132-1140 LID - 10.1177/08830738251396170 [doi] AB - Fatigue is common in children with multiple sclerosis. This cross-sectional study aimed to determine the prevalence of fatigue, sleep disorders, and subjective sleep quality in children with multiple sclerosis, along with their relationships to mood, quality of life, physical activity, and multiple sclerosis disease characteristics. Validated questionnaires were completed, and objective sleep quality was evaluated with polysomnography. Of the 18 children recruited (median age 16.0 years), 72% reported fatigue and 61% experienced subjective sleep disturbance. Fourteen sleep studies were completed, from which 3 children (21%) were diagnosed with sleep disorders: 2 with periodic limb movement disorder and 1 with mild obstructive sleep apnea. Sleep architecture was fragmented in 13 children (93%). Fatigue correlated with subjective sleep disturbance measures. This study demonstrates an increased frequency of subjective and objective sleep disturbance in children with multiple sclerosis. Polysomnography should be considered in children with multiple sclerosis who report fatigue and subjective sleep disturbance. FAU - Tran, Jessica AU - Tran J AD - Department of Paediatrics, University of Melbourne, Parkville, Australia. AD - Neuroscience Research Group, Murdoch Children's Research Institute, Parkville, Australia. AD - Department of Neurology, Royal Children's Hospital, Melbourne, Parkville, Australia. AD - Department of Respiratory and Sleep Medicine, Royal Children's Hospital, Melbourne, Parkville, Australia. FAU - Adams, Anne-Marie AU - Adams AM AD - Department of Paediatrics, University of Melbourne, Parkville, Australia. AD - Department of Respiratory and Sleep Medicine, Royal Children's Hospital, Melbourne, Parkville, Australia. AD - Respiratory Research Group, Murdoch Children's Research Institute, Parkville, Australia. FAU - Said, Jackie L AU - Said JL AD - Neuroscience Research Group, Murdoch Children's Research Institute, Parkville, Australia. AD - Department of Neurology, Royal Children's Hospital, Melbourne, Parkville, Australia. FAU - Kornberg, Andrew J AU - Kornberg AJ AD - Department of Paediatrics, University of Melbourne, Parkville, Australia. AD - Neuroscience Research Group, Murdoch Children's Research Institute, Parkville, Australia. AD - Department of Neurology, Royal Children's Hospital, Melbourne, Parkville, Australia. FAU - Vandeleur, Moya AU - Vandeleur M AD - Department of Respiratory and Sleep Medicine, Royal Children's Hospital, Melbourne, Parkville, Australia. AD - Respiratory Research Group, Murdoch Children's Research Institute, Parkville, Australia. FAU - Yiu, Eppie M AU - Yiu EM AUID- ORCID: 0000-0001-6704-8402 AD - Department of Paediatrics, University of Melbourne, Parkville, Australia. AD - Neuroscience Research Group, Murdoch Children's Research Institute, Parkville, Australia. AD - Department of Neurology, Royal Children's Hospital, Melbourne, Parkville, Australia. LA - eng PT - Journal Article DEP - 20251222 PL - United States TA - J Child Neurol JT - Journal of child neurology JID - 8606714 SB - IM MH - Humans MH - *Fatigue/epidemiology/etiology MH - *Multiple Sclerosis/complications/epidemiology MH - Female MH - Male MH - Child MH - *Sleep Wake Disorders/epidemiology/etiology MH - Adolescent MH - Cross-Sectional Studies MH - Polysomnography MH - Surveys and Questionnaires MH - Quality of Life MH - Prevalence OTO - NOTNLM OT - adolescents OT - children OT - fatigue OT - multiple sclerosis OT - sleep COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/12/22 19:42 MHDA- 2026/08/01 06:35 CRDT- 2025/12/22 12:13 PHST- 2026/08/01 06:35 [medline] PHST- 2025/12/22 19:42 [pubmed] PHST- 2025/12/22 12:13 [entrez] AID - 10.1177/08830738251396170 [doi] PST - ppublish SO - J Child Neurol. 2026 Sep;41(8):1132-1140. doi: 10.1177/08830738251396170. Epub 2025 Dec 22. PMID- 41427097 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251222 LR - 20251224 IS - 1735-4587 (Print) IS - 2008-2215 (Electronic) IS - 1735-4587 (Linking) VI - 20 IP - 4 DP - 2025 Oct TI - Designing and Compiling a Special Parenting Package to Use Digital Technology in Iranian Children and Adolescents. PG - 441-451 LID - 10.18502/ijps.v20i4.19681 [doi] AB - Objective: This study aimed to design and validate a culturally tailored educational package for Iranian parents of children and adolescents aged 0 to 18. The package addresses the safe and effective use of a range of digital technologies, including social media, online games, and educational applications. It focuses on enhancing parents' knowledge, monitoring capabilities, and strategies to mitigate digital risks, with consideration of Iranian cultural values and family dynamics. Method : The content was developed through a review of literature across multiple English and Persian databases, including PubMed, Scopus, Web of Science, Iran Medex, Magiran, and SID. Relevant keywords and MeSH terms related to parenting, digital technology, and cultural adaptation were used. Cultural appropriateness was ensured through consultations with a panel of experts in psychiatry, child development, and digital education, along with qualitative input from Iranian parents via focus groups and interviews. Results: The finalized educational package comprises 12 well-structured chapters covering topics such as digital literacy, online safety, parental supervision, balancing screen time, effective family communication, and related legal and ethical issues contextualized for Iranian society. The package achieved high content validity, with all chapters scoring above 0.79 on the Content Validity Index (CVI) and Content Validity Ratio (CVR). Conclusion: This culturally adapted package offers an evidence-based resource that empowers Iranian parents by increasing their awareness, sharpening their supervisory and communication skills, and supporting the healthy and responsible use of digital technologies among their children. Future steps include pilot testing and evaluating the package's effectiveness and scalability in real-world settings. CI - Copyright (c) 2025 Tehran University of Medical Sciences. Published by Tehran University of Medical Sciences. FAU - Alaghband Rad, Javad AU - Alaghband Rad J AD - Department of Psychiatry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. FAU - Karamooz, Anahita AU - Karamooz A AD - Department of Psychiatry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran. FAU - Sharifi, Vandad AU - Sharifi V AD - Department of Psychiatry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. FAU - Raaii, Farzaneh AU - Raaii F AD - Department of Psychiatry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran. LA - eng PT - Journal Article PL - Iran TA - Iran J Psychiatry JT - Iranian journal of psychiatry JID - 101302041 PMC - PMC12712400 OTO - NOTNLM OT - Children and Adolescent OT - Cultural Characteristics OT - Digital Technology OT - Education OT - Parents COIS- None. EDAT- 2025/12/22 12:56 MHDA- 2025/12/22 12:57 PMCR- 2025/10/01 CRDT- 2025/12/22 07:00 PHST- 2025/05/16 00:00 [received] PHST- 2025/07/22 00:00 [revised] PHST- 2025/07/30 00:00 [accepted] PHST- 2025/12/22 12:57 [medline] PHST- 2025/12/22 12:56 [pubmed] PHST- 2025/12/22 07:00 [entrez] PHST- 2025/10/01 00:00 [pmc-release] AID - IJPS-20-441 [pii] AID - 10.18502/ijps.v20i4.19681 [doi] PST - ppublish SO - Iran J Psychiatry. 2025 Oct;20(4):441-451. doi: 10.18502/ijps.v20i4.19681. PMID- 41426692 OWN - NLM STAT- MEDLINE DCOM- 20251222 LR - 20251224 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Expanding the theory of planned behavior to predict fruits and vegetables consumption among a sample of women in Saudi Arabia. PG - 1720598 LID - 10.3389/fpubh.2025.1720598 [doi] LID - 1720598 AB - BACKGROUND: Adequate fruit and vegetable (F&V) intake is a key component of a healthy diet and is influenced by both psychological and environmental factors. AIM: to explore determinants of F&V consumption among Saudi adult women, applying an extended Theory of Planned Behavior (TPB) model. METHODS: A cross-sectional survey recruited 476 Saudi adult women aged 18-59 across all five regions of Saudi Arabia. Data were collected using a validated online questionnaire assessing TPB constructs, socio-demographics, lifestyle behaviors, and dietary patterns. Structural equation modeling (SEM) was used to test both the original and extended TPB models. RESULTS: Participants held positive attitudes but demonstrated low adherence, consuming a mean of 3.33 F&V servings daily. In the original TPB model, intention, and perceived behavioral control (PBC) significantly predicted behavior (R(2) = 31%), while attitude, subjective norms, and PBC predicted intention (R(2) = 75%). The extended model explained 45% of the variance in behavior, with PBC as the sole direct significant predictor. Knowledge and family meal frequency positively influenced attitudes, while F&V purchasing, and a healthy diet were associated with higher PBC. CONCLUSION: PBC emerged as the only direct predictor of behavior in the extended model. Moreover, this study highlighted the crucial role of PBC in translating intention into the actual consumption of fruits and vegetables among Saudi women. Family-centered strategies that strengthen women's confidence and skills in healthy meal planning may effectively bridge the intention-behavior gap. CI - Copyright (c) 2025 Abusalih, Alasmari, Abduljawad, Almaski, Almughamisi, Fatani, Tashkandi, Aljehani, Saaty and Benajiba. FAU - Abusalih, Howeida AU - Abusalih H AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Alasmari, Sarah A AU - Alasmari SA AD - College of Health Sciences, Public Health Department, Saudi Electronic University, Riyadh, Saudi Arabia. FAU - Abduljawad, Suha Hashim AU - Abduljawad SH AD - College of Applied Medical Sciences, Department of Clinical Nutrition, Taibah University, Medina, Saudi Arabia. FAU - Almaski, Ameerah AU - Almaski A AD - College of Applied Medical Sciences, Department of Clinical Nutrition, Taibah University, Medina, Saudi Arabia. FAU - Almughamisi, Manal AU - Almughamisi M AD - College of Applied Medical Sciences, Department of Clinical Nutrition, Taibah University, Medina, Saudi Arabia. FAU - Fatani, Asmaa AU - Fatani A AD - Food and Nutrition Department, Human Sciences and Design Faculty, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Tashkandi, Bayan AU - Tashkandi B AD - Food and Nutrition Department, Human Sciences and Design Faculty, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Aljehani, Abeer A AU - Aljehani AA AD - Food and Nutrition Department, Human Sciences and Design Faculty, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Saaty, Afnan H AU - Saaty AH AD - Food and Nutrition Department, Human Sciences and Design Faculty, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Benajiba, Nada AU - Benajiba N AD - Ibn Tofail University-CNESTEN, Joint Research Unit in Nutrition and Food, RDC-Nutrition AFRA/IAEA, Rabat, Morocco. LA - eng PT - Journal Article DEP - 20251204 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Saudi Arabia MH - Female MH - *Fruit MH - Adult MH - *Vegetables MH - Cross-Sectional Studies MH - Middle Aged MH - Adolescent MH - Surveys and Questionnaires MH - Young Adult MH - *Feeding Behavior/psychology MH - Intention MH - Health Knowledge, Attitudes, Practice MH - *Health Behavior MH - *Transtheoretical Model MH - Diet/statistics & numerical data MH - Theory of Planned Behavior PMC - PMC12713309 OTO - NOTNLM OT - Saudi Arabia OT - adult women OT - attitude OT - fruits and vegetables consumption OT - intention OT - perceived behavioral control OT - social norms OT - theory of planned behavior COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer BA declared a shared affiliation with the authors AF, BT, AAA, and AS to the handling editor at the time of review. EDAT- 2025/12/22 18:09 MHDA- 2025/12/22 18:10 PMCR- 2025/12/04 CRDT- 2025/12/22 06:56 PHST- 2025/10/08 00:00 [received] PHST- 2025/11/09 00:00 [revised] PHST- 2025/11/14 00:00 [accepted] PHST- 2025/12/22 18:10 [medline] PHST- 2025/12/22 18:09 [pubmed] PHST- 2025/12/22 06:56 [entrez] PHST- 2025/12/04 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1720598 [doi] PST - epublish SO - Front Public Health. 2025 Dec 4;13:1720598. doi: 10.3389/fpubh.2025.1720598. eCollection 2025. PMID- 41426690 OWN - NLM STAT- MEDLINE DCOM- 20251222 LR - 20251224 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Ethnic and residential differences in adherence to the 24-h movement guidelines and self-reported physical fitness among Zhuang and Han adolescents in southern China. PG - 1631277 LID - 10.3389/fpubh.2025.1631277 [doi] LID - 1631277 AB - BACKGROUND: The 24-h movement guidelines integrate physical activity (PA), screen time, and sleep for health benefits, yet little is known about how adherence to these guidelines relates to physical fitness (PF) among adolescents, particularly in the context of ethnic and residential differences. This study examines the independent and combined associations of adhering to the 24-h movement guidelines with self-reported PF among Han and Zhuang adolescents in southern China, while exploring potential differences by residence and ethnicity. METHODS: Cross-sectional data from 6,913 adolescents were analyzed using a validated self-reported questionnaire to assess adherence to the 24-h movement guidelines and PF components (cardiorespiratory fitness, cardiorespiratory fitness, speed/agility, muscular strength, and flexibility). Generalized linear models were used to examine associations. RESULTS: In this sample, only 1.6% of participants met the overall guidelines. Meeting more guidelines was significantly (p < 0.001) associated with better self-reported PF indicators. The combinations containing moderate-to-vigorous physical activity (MVPA) guideline were significantly (p < 0.05) associated with self-reported PF indicators enhancement compared to those combinations without MVPA guideline. Meeting screen time guideline was significantly (p < 0.05) associated with more self-reported PF indicators, but not in the case of meeting sleep duration guideline. Most of the results were similar for Han and Zhuang ethnicity, whereas residence differences exerted a significant impact on the relationship between adherence to "Screen only," "Sleep only," and "Screen + sleep" guideline and self-reported PF indicators. CONCLUSION: Our findings highlight the critical role of adhering to the 24-h movement guidelines, mainly MVPA, in improving self-reported PF among adolescents and underscore the need to address urban-rural disparities in promoting the 24-h movement guidelines. CI - Copyright (c) 2025 Qian, Tan, Tang and Zou. FAU - Qian, Hongsheng AU - Qian H AD - School of Physical Education, Wuhan Sports University, Wuhan, China. FAU - Tan, Jingwang AU - Tan J AD - Department of Sport and Exercise Science, College of Education, Zhejiang University, Hangzhou, China. FAU - Tang, Jiaxing AU - Tang J AD - School of Physical Education, Xiangnan University, Chenzhou, China. FAU - Zou, Yu AU - Zou Y AD - Department of Sport and Exercise Science, College of Education, Zhejiang University, Hangzhou, China. LA - eng PT - Journal Article DEP - 20251204 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - Zhuang people RN - Han Chinese people SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - China MH - Cross-Sectional Studies MH - *Ethnicity/statistics & numerical data MH - *Exercise MH - *Guideline Adherence/statistics & numerical data MH - Guidelines as Topic MH - *Physical Fitness MH - *Residence Characteristics/statistics & numerical data MH - Screen Time MH - Self Report MH - Surveys and Questionnaires MH - East Asian People PMC - PMC12711711 OTO - NOTNLM OT - ethnicity OT - movement guidelines OT - physical activity OT - physical fitness OT - residence OT - screen time OT - sleep duration COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/22 18:09 MHDA- 2025/12/22 18:10 PMCR- 2025/12/04 CRDT- 2025/12/22 06:56 PHST- 2025/05/19 00:00 [received] PHST- 2025/11/16 00:00 [revised] PHST- 2025/11/24 00:00 [accepted] PHST- 2025/12/22 18:10 [medline] PHST- 2025/12/22 18:09 [pubmed] PHST- 2025/12/22 06:56 [entrez] PHST- 2025/12/04 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1631277 [doi] PST - epublish SO - Front Public Health. 2025 Dec 4;13:1631277. doi: 10.3389/fpubh.2025.1631277. eCollection 2025. PMID- 41425778 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251222 LR - 20251224 IS - 2589-790X (Electronic) IS - 2589-790X (Linking) VI - 7 IP - 11 DP - 2025 Nov TI - Reducing Socioeconomic Inequalities in Adult Cardiovascular Disease Risk by Targeting Unhealthy Movement Behaviours During Adolescence: A Protocol. PG - 1495-1506 LID - 10.1016/j.cjco.2025.08.002 [doi] AB - Populations with lower socioeconomic position (SEP) are at increased risk of developing cardiovascular disease (CVD). Movement behaviours, including physical activity, sedentary behaviour, and sleep, contribute to socioeconomic gradients in CVD risk, as low-SEP populations are less likely to meet evidence-informed recommendations for these behaviours. Adolescence represents a sensitive period for establishing lifelong health behaviours, with CVD risk beginning to accumulate before adulthood. This study will model the potential effect of adolescent movement behaviour interventions on socioeconomic inequalities in adult CVD risk. We will conduct a population-based cohort study of adolescents from the Add Health study, recruited in 1994-1995 from the US and followed into adulthood. Unhealthy movement behaviours, including a low level of moderate-to-vigorous physical activity, a high level of recreational screen time, and short sleep duration, will be operationalized based on the 24-hour Movement Guidelines and measured twice during adolescence (ages 12-24 years). Parental educational attainment and family financial hardship will be used to capture SEP in adolescence. The outcome will be the 30-year risk of CVD, assessed in adulthood (ages 33-41 years) using a validated risk score that incorporates objectively measured biomarkers, demographic information, and self-reported health indicators. We will perform causal decompositions to quantify the change of socioeconomic inequalities in adult CVD risk under 2 interventional scenarios: (i) elimination (unhealthy movement behaviours are eliminated in the whole population of adolescents); and (ii) equalization (the distributions of unhealthy movement behaviours for low-SEP adolescents are equalized to those of high-SEP adolescents). This study will provide insights into how modifying adolescent movement behaviours may contribute to reducing socioeconomic inequalities in CVD risk. CI - (c) 2025 The Authors. FAU - Grubic, Nicholas AU - Grubic N AD - Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. FAU - Maximova, Katerina AU - Maximova K AD - Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. AD - MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada. FAU - Chiolero, Arnaud AU - Chiolero A AD - Department of Epidemiology, Biostatistics and Occupational Health, School of Population and Global Health, McGill University, Montreal, Quebec, Canada. AD - Population Health Laboratory (#PopHealthLab), University of Fribourg, Fribourg, Switzerland. AD - Swiss School of Public Health (SSPH+), Zurich, Switzerland. FAU - Siddiqi, Arjumand AU - Siddiqi A AD - Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. AD - Edwin S.H. Leong Centre for Healthy Children, Hospital for Sick Children, Toronto, Ontario, Canada. AD - Department of Social and Behavioural Sciences, Harvard School of Public Health, Boston, Massachusetts, USA. AD - Department of Health Behaviour, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Carsley, Sarah AU - Carsley S AD - Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. AD - Health Promotion, Chronic Disease and Injury Prevention, Public Health Ontario, Toronto, Ontario, Canada. FAU - Batomen, Brice AU - Batomen B AD - Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. FAU - Harris, Kathleen Mullan AU - Harris KM AD - Department of Sociology and Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Carmeli, Cristian AU - Carmeli C AD - Population Health Laboratory (#PopHealthLab), University of Fribourg, Fribourg, Switzerland. AD - Swiss School of Public Health (SSPH+), Zurich, Switzerland. LA - eng PT - Journal Article DEP - 20250813 PL - United States TA - CJC Open JT - CJC open JID - 101763635 PMC - PMC12713191 OTO - NOTNLM OT - adolescence OT - cardiovascular disease OT - causal decomposition OT - inequalities OT - movement behaviours EDAT- 2025/12/22 18:09 MHDA- 2025/12/22 18:10 PMCR- 2025/08/13 CRDT- 2025/12/22 06:47 PHST- 2025/06/10 00:00 [received] PHST- 2025/08/07 00:00 [accepted] PHST- 2025/12/22 18:10 [medline] PHST- 2025/12/22 18:09 [pubmed] PHST- 2025/12/22 06:47 [entrez] PHST- 2025/08/13 00:00 [pmc-release] AID - S2589-790X(25)00521-9 [pii] AID - 10.1016/j.cjco.2025.08.002 [doi] PST - epublish SO - CJC Open. 2025 Aug 13;7(11):1495-1506. doi: 10.1016/j.cjco.2025.08.002. eCollection 2025 Nov. PMID- 41424726 OWN - NLM STAT- MEDLINE DCOM- 20251222 LR - 20261016 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 13 DP - 2025 TI - Cross-cultural adaptation and validation of a Resistance Training Skill Battery for use in Chinese-speaking adolescents. PG - e20387 LID - 10.7717/peerj.20387 [doi] LID - e20387 AB - PURPOSE: Although the Resistance Training Skills Battery (RTSB) is a well-established instrument for assessing resistance training (RT) skill competency in Western populations, its applicability to Chinese adolescents remains unvalidated. This study aimed to translate, cross-culturally adapted, and validated the RTSB for Mandarin-speaking Chinese adolescents. METHODS: Employing established guidelines for cross-cultural adaptation, our study involved translating the RTSB into Chinese (RTSB-C), followed by back-translation, adaptation, and validation. The study quantified test-retest reliability, intra- and inter-rater reliability, and construct validity. Adolescents aged 12-16 years (n = 64) underwent two RTSB-C assessments, two weeks apart. Muscular fitness was evaluated using muscle fitness tests (handgrip strength, timed push-up, and countermovement jumps) to establish criterion validity. RESULTS: The RTSB-C demonstrated fair to excellent test-retest reliability across the two timepoints, the intra-class coefficient (ICC) for the RTSB-C was notably high at 0.94 (95% CI [0.90-0.95]); The intra-rater reliability was 0.94 (p < 0.001), and inter-rater reliability was 0.41-0.93 (p < 0.05). Construct validity was confirmed through linear regression analysis, with the model accounting for 46.8% of the variance in muscle fitness scores (MFS), and with gender (r = 0.47, p < 0.001) and RTSB-C scores (r = 0.45, p < 0.001) emerging as significant predictors. CONCLUSIONS: We successfully translated and cross-culturally adapted the RTSB from English to Chinese, affirming its reliability and validity in assessing the RT skills of Chinese-speaking adolescents. The RTSB-C is recommended for accurate evaluation of RT competence in this demographic. CI - (c)2025 Zha et al. FAU - Zha, Xiaolu AU - Zha X AD - School of Physical Education, Shanghai University of Sport, Shanghai, China. FAU - Lubans, David AU - Lubans D AD - Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland. AD - Centre for Active Living and Learning, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Smith, Jordan AU - Smith J AD - Centre for Active Living and Learning, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Wang, Ran AU - Wang R AD - School of Athletic Performance, Shanghai University of Sport, Shanghai, China. LA - eng GR - Shanghai Key Lab of Human Performance (Shanghai University of sport)/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20251215 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 RN - Chinese people SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - Reproducibility of Results MH - Child MH - *Resistance Training MH - China MH - *Cross-Cultural Comparison MH - Translations MH - East Asian People PMC - PMC12713556 OTO - NOTNLM OT - Motor skill OT - Muscular fitness OT - Physical fitness OT - Strength training OT - Youth training COIS- The authors declare there are no competing interests. EDAT- 2025/12/22 18:09 MHDA- 2025/12/22 18:10 PMCR- 2025/12/15 CRDT- 2025/12/22 06:37 PHST- 2025/05/07 00:00 [received] PHST- 2025/10/22 00:00 [accepted] PHST- 2025/12/22 18:10 [medline] PHST- 2025/12/22 18:09 [pubmed] PHST- 2025/12/22 06:37 [entrez] PHST- 2025/12/15 00:00 [pmc-release] AID - 20387 [pii] AID - 10.7717/peerj.20387 [doi] PST - epublish SO - PeerJ. 2025 Dec 15;13:e20387. doi: 10.7717/peerj.20387. eCollection 2025. PMID- 41423608 OWN - NLM STAT- MEDLINE DCOM- 20260123 LR - 20260602 IS - 1471-244X (Electronic) IS - 1471-244X (Linking) VI - 26 IP - 1 DP - 2025 Dec 21 TI - A pilot study of the plasma and urinary neurotransmitters in Chinese children with autism spectrum disorder. PG - 59 LID - 10.1186/s12888-025-07682-7 [doi] LID - 59 AB - BACKGROUND: Recent studies have indicated that there are imbalances in neurotransmitter levels in children with autism spectrum disorder (ASD). Alterations in peripheral blood and urinary neurotransmitter levels may serve as biomarkers for ASD. METHODS: This study aims to explore the relationship between neurotransmitter levels and the severity of ASD. Totally, forty sex-, age-, and ethnically matched typically developing (TD) children were recruited to compare the neurotransmitter levels with ASD aged over 3 years. Differences in plasma and urinary neurotransmitter levels between TD children and children with ASD were compared using the Mann-Whitney U test. For the indicators that showed significant differences, further multivariate regression analysis was conducted to assess the association between individual neurotransmitters and Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) Calibrated Severity Score (CSS). Finally, a restricted cubic spline (RCS) model was applied to explore the dose-response relationship between neurotransmitter concentrations and ADOS-2 CSS. RESULTS: Plasma levels of dopamine (DA), normetanephrine (NMN), 5-hydroxytryptamine (5-HT), gamma-aminobutyric acid (gamma-GABA) levels in ASD were significantly higher than those in TD children while plasma levels of norepinephrine (NE), tyrosine (Tyr) were significantly lower. Urinary levels of NMN were significantly lower, while epinephrine (E), NE, vanillylmandelic acid (VMA), homovanillic acid (HVA) were significantly higher in children with ASD compared to TD. After adjusting for confounders of age, sex and BMI, plasma GABA was negatively associated with ADOS-2 CSS, while urinary NE and NMN were positively associated with ADOS severity scores (P ＜ 0.05). Multiple regression analysis indicated that plasma GABA and urinary NE and NMN levels explained 26.9%, 24.8% and 15.8% of the variability in ADOS-2 CSS for ASD. The RCS analysis results were largely consistent with the linear regression analysis results. Plasma GABA and urinary NE, and NMN exhibited a linear correlation with ADOS-2 CSS. Plasma NE and Tyr showed a U-shaped curve relationship with the ADOS-2 CSS (P< 0.05). CONCLUSIONS: A significant negative correlation was observed between plasma GABA neurotransmitter concentrations and ASD severity. In contrast, NE and NMN levels in urine showed significantly positive correlations with ASD severity. Both excessively low and excessively high plasma NE and Tyr levels may be associated with more severe autism symptoms, suggesting a disruption in peripheral neurotransmitter levels in children with ASD. Future studies with larger sample sizes are required for prediction and validation. The peripheral neurotransmitters may serve as potential auxiliary biomarkers for assessing the severity of autism. CI - (c) 2025. The Author(s). FAU - Xin, Yingying AU - Xin Y AUID- ORCID: 0000-0001-7116-9231 AD - Department of Child Health, Wuhan Children's Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, China. FAU - Yang, Yifan AU - Yang Y AD - Department of Child Health, Wuhan Children's Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, China. FAU - Qian, Qiaoqiao AU - Qian Q AD - Department of Neurology, Wuhan Children's Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, China. FAU - Xia, Ting AU - Xia T AD - Department of Child Health, Wuhan Children's Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, China. FAU - Zhang, Wanqing AU - Zhang W AD - Wuhan University of Science and Technology, Wuhan, 430016, China. FAU - Dai, Taoying AU - Dai T AD - Department of Child Health, Wuhan Children's Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, China. FAU - Li, Ruizhen AU - Li R AD - Department of Child Health, Wuhan Children's Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, China. FAU - Liu, Zhisheng AU - Liu Z AD - Department of Neurology, Wuhan Children's Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, China. liuzsc@126.com. FAU - Zhang, Chuanjie AU - Zhang C AD - Department of Child Health, Wuhan Children's Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, China. cjzhang45@126.com. LA - eng PT - Journal Article DEP - 20251221 PL - England TA - BMC Psychiatry JT - BMC psychiatry JID - 100968559 RN - 0 (Neurotransmitter Agents) RN - 0 (Biomarkers) RN - X4W3ENH1CV (Norepinephrine) RN - 333DO1RDJY (Serotonin) RN - VTD58H1Z2X (Dopamine) RN - 56-12-2 (gamma-Aminobutyric Acid) RN - Chinese people SB - IM MH - Humans MH - *Autism Spectrum Disorder/blood/urine MH - Male MH - Female MH - *Neurotransmitter Agents/blood/urine MH - Pilot Projects MH - Child, Preschool MH - Child MH - Biomarkers/blood/urine MH - China MH - Norepinephrine/blood/urine MH - Severity of Illness Index MH - Serotonin/blood/urine MH - Dopamine/blood/urine MH - gamma-Aminobutyric Acid/blood/urine MH - East Asian People PMC - PMC12829056 OTO - NOTNLM OT - Autism diagnostic observation schedule OT - Autism spectrum disorder OT - Calibrated severity score OT - Neurotransmitter COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Wuhan Children's Hospital, Huazhong University of Science and Technology (No:2024R017-E01). Informed consent was obtained from the guardians of the children involved in this study, which was in accordance with the Declaration of Helsinki and the Ethical Review Methods for Biomedical Research involving Humans adopted by the National Health and Family Planning Commission of the People's Republic of China. This research was registered in China National Medical Research Registration and Filing Information System, the Clinical Trial Number is MR-42-24-023506. Author agreement: All authors have read and agreed to the published version of the manuscript. The article is the our original work, hasn't received prior publication and isn't under consideration for publication elsewhere. Competing interests: The authors declare no competing interests. Consent for publication: Informed consent was obtained from the guardians of the children involved in this study for the publication of children's details. EDAT- 2025/12/22 00:28 MHDA- 2026/01/23 06:30 PMCR- 2025/12/21 CRDT- 2025/12/21 23:13 PHST- 2025/07/13 00:00 [received] PHST- 2025/12/01 00:00 [accepted] PHST- 2026/01/23 06:30 [medline] PHST- 2025/12/22 00:28 [pubmed] PHST- 2025/12/21 23:13 [entrez] PHST- 2025/12/21 00:00 [pmc-release] AID - 10.1186/s12888-025-07682-7 [pii] AID - 7682 [pii] AID - 10.1186/s12888-025-07682-7 [doi] PST - epublish SO - BMC Psychiatry. 2025 Dec 21;26(1):59. doi: 10.1186/s12888-025-07682-7. PMID- 41422970 OWN - NLM STAT- MEDLINE DCOM- 20260119 LR - 20260119 IS - 1573-2517 (Electronic) IS - 0165-0327 (Linking) VI - 398 DP - 2026 Apr 1 TI - Gastrointestinal symptoms mediate the association between dietary factors and sleep disturbances: A cross-sectional study on preschool children. PG - 120994 LID - S0165-0327(25)02436-X [pii] LID - 10.1016/j.jad.2025.120994 [doi] AB - BACKGROUND: Sleep disturbances in preschool children are associated with dietary patterns and eating behaviors. Gastrointestinal symptoms, which frequently result from poor dietary factors, may further impair sleep. This study examines the mediating effect of gastrointestinal symptoms in the association between dietary factors and sleep disturbances. METHODS: A cross-sectional online investigation recruited 7425 participants in Beijing, with 7170 included in the final analysis. Validated scales, including the Sleep Disturbance Scale for Children, Chinese Preschoolers' Eating Behavior Questionnaire, Preschool Nutrition Quotient Questionnaire, and Gastrointestinal Symptom Rating Scale, were used to assess dietary composition, eating behaviors, gastrointestinal symptoms, and sleep disturbances. RESULTS: Gastrointestinal symptoms exacerbate the damage to sleep caused by unhealthy dietary factors. Proportions mediated of gastrointestinal symptoms ranged from 17.98 % to 31.35 % on the total score of the Sleep Disturbance Scale for Children. A dietary pattern high in beverages and low in bean and fish products adversely affected sleep through gastrointestinal symptoms. The association between unhealthy eating behaviors and sleep disturbances has been validated, with proportion mediated of 61.89 % between sleep breathing disorders and low satiety responsiveness. LIMITATIONS: As a cross-sectional study, these results cannot rule out reverse causality-where sleep disturbances may influence eating behavior. or gastrointestinal symptoms. CONCLUSIONS: These findings emphasize the importance of correcting unhealthy dietary factors as key drivers of sleep disturbances. Interventions aimed at improving gastrointestinal health can simultaneously mitigate the harmful effects of unhealthy dietary factors, offering dual benefits for sleep in preschool children. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Jiang, Jiyu AU - Jiang J AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 11 North Third Ring Road East, Chaoyang District, Beijing, 100029, PR China. FAU - Ma, Xueyan AU - Ma X AD - Institute of Chinese Medicine Epidemic Disease, Beijing University of Chinese Medicine, Yangguang South Street, Fangshan District, Beijing, 102488, PR China. FAU - Liu, Lina AU - Liu L AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 11 North Third Ring Road East, Chaoyang District, Beijing, 100029, PR China. FAU - Li, Xue AU - Li X AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 11 North Third Ring Road East, Chaoyang District, Beijing, 100029, PR China. FAU - Hou, Senlong AU - Hou S AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 11 North Third Ring Road East, Chaoyang District, Beijing, 100029, PR China. FAU - Li, Shuxuan AU - Li S AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 11 North Third Ring Road East, Chaoyang District, Beijing, 100029, PR China. FAU - Zhang, Hanwen AU - Zhang H AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 11 North Third Ring Road East, Chaoyang District, Beijing, 100029, PR China. FAU - Ma, Qingpu AU - Ma Q AD - Qi-Huang Chinese Medicine School, Beijing University of Chinese Medicine, 11 North Third Ring Road East, Beijing, 100029, PR China. FAU - Yu, He AU - Yu H AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 11 North Third Ring Road East, Chaoyang District, Beijing, 100029, PR China. FAU - Liu, Tiegang AU - Liu T AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 11 North Third Ring Road East, Chaoyang District, Beijing, 100029, PR China. Electronic address: liutg@bucm.edu.cn. FAU - Gu, Xiaohong AU - Gu X AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 11 North Third Ring Road East, Chaoyang District, Beijing, 100029, PR China. Electronic address: guxiaohong1962@163.com. LA - eng PT - Journal Article DEP - 20251219 PL - Netherlands TA - J Affect Disord JT - Journal of affective disorders JID - 7906073 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Child, Preschool MH - Female MH - *Sleep Wake Disorders/epidemiology/etiology MH - *Feeding Behavior MH - *Gastrointestinal Diseases/complications/epidemiology MH - Surveys and Questionnaires MH - *Diet/adverse effects MH - China/epidemiology OTO - NOTNLM OT - Child OT - Dietary pattern OT - Eating behavior OT - Mediating effect OT - Sleep disturbance COIS- Declaration of competing interest The authors declare that they have no competing interests. EDAT- 2025/12/22 00:28 MHDA- 2026/01/20 00:37 CRDT- 2025/12/21 19:35 PHST- 2025/09/12 00:00 [received] PHST- 2025/12/12 00:00 [revised] PHST- 2025/12/18 00:00 [accepted] PHST- 2026/01/20 00:37 [medline] PHST- 2025/12/22 00:28 [pubmed] PHST- 2025/12/21 19:35 [entrez] AID - S0165-0327(25)02436-X [pii] AID - 10.1016/j.jad.2025.120994 [doi] PST - ppublish SO - J Affect Disord. 2026 Apr 1;398:120994. doi: 10.1016/j.jad.2025.120994. Epub 2025 Dec 19. PMID- 41421885 OWN - NLM STAT- MEDLINE DCOM- 20260508 LR - 20260508 IS - 1878-1861 (Electronic) IS - 1878-1861 (Linking) VI - 29 IP - 5 DP - 2026 May TI - Deriving and validating a short version of the Physical Literacy in Children Questionnaire. PG - 535-542 LID - S1440-2440(25)00528-6 [pii] LID - 10.1016/j.jsams.2025.11.018 [doi] AB - OBJECTIVES: Physical literacy encompasses individual capabilities for lifelong physical activity. The Physical Literacy in Children Questionnaire (PL-C Quest) is a 30-item pictorial tool designed to measure children's physical literacy across four domains (physical, psychological, social, cognitive). However, a shorter version may be desirable for research and practice. Therefore, the study goal was to derive a short version of the PL-C Quest. DESIGN: Observational/cross-sectional. METHODS: The PL-C Quest was completed by children aged 8-12 years (N = 620) via digital tablet. To select the most indicative items, we calculated a self-developed aggregate score consisting of nine indicators: factor loading, internal consistency, item difficulty, item-total correlation, univariate and multivariate associations with proxy-reported physical activity, eligibility for boys and for girls (test fairness/subgroup validity), and cross-cultural generalisability. Items with the highest scores in each domain (points [pts]) were selected for the short version. We analysed the association between the sum scores of the short and long version. RESULTS: The items 'speed' (22pts), 'cardiovascular endurance' (20pts), 'muscular endurance' (20pts), and 'movement skills' (5pts) were selected for the physical domain; 'motivation' (20pts), 'engagement/enjoyment' (19pts), and 'confidence' (14pts) for the psychological; 'relationships' (15pts) and 'society/culture' (14pts) for the social; 'strategy/planning' (20 pts), 'tactics' (18pts), and 'content knowledge' (17pts) for the cognitive domain. The domain-specific aggregate scores of the short version were strongly related to the respective scores of the long version (0.74 /= 10 mg/L. Pearson's correlations were used to examine unadjusted associations between circulating and stimulated cytokine composites, within and across visits. Multiple linear regression was then used to test concurrent associations between the circulating and stimulated cytokine composites, and the within-person stability of each measure across visits, adjusting for sex, body mass index, perceived stress, physical activity, diet quality, and sleep quality. RESULTS: Study visits occurred 13 weeks +/- 8 days apart. The circulating and stimulated cytokine composites were significantly correlated at visit 1 (r= 0.374, p<0.01) and at visit 2 (r=0.246, p = 0.02). This association remained significant in regression analyses at both visit 1 (B [95 % CI] = 0.407 [0.196, 0.617], p < 0.01) and visit 2 (B [95 % CI] = 0.312 [0.041, 0.584], p=0.03). The circulating cytokine composite at visit 1 was not significantly associated with the circulating cytokine composite at visit 2 in either correlation (r=-0.009, p=0.94) or regression (B [95 % CI] = -0.007 [-0.192, 0.179], p = 0.94) analyses. Stimulated cytokine production at visit 1 was significantly associated with stimulated cytokine production at visit 2 in both correlation (r=0.515, p<0.01) and regression analyses (B [95 % CI] = 0.497 [0.293 0.701], p<0.01). CONCLUSIONS: Contrasting with some past research, circulating cytokines were significantly associated with stimulated cytokine production in the present sample concurrently at both visits. Stimulated cytokine production was more stable within-person across visits ( approximately 13 weeks apart) compared to circulating cytokines in these students. Measurement of stimulated cytokines may be informative for understanding between-person differences in inflammation-related disease risk in younger adults, in part because they appear more stable compared to circulating cytokines. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - Davis, Kristin M AU - Davis KM AD - Department of Psychology, Wayne State University, 5057 Woodward Ave, Detroit, MI 48202, United States. FAU - Wright, Molly A AU - Wright MA AD - Departmentof Biobehavioral Health, Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA 16802, United States. FAU - Engeland, Christopher G AU - Engeland CG AD - Departmentof Biobehavioral Health, Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA 16802, United States; Ross and Carol Nese University of Nursing, Pennsylvania State University, Nursing Sciences Building, University Park, PA 16802, United States. FAU - Murdock, Kyle W AU - Murdock KW AD - Departmentof Biobehavioral Health, Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA 16802, United States. Electronic address: kwm20@psu.edu. LA - eng GR - T32 AG049676/AG/NIA NIH HHS/United States GR - UL1 TR002014/TR/NCATS NIH HHS/United States PT - Journal Article DEP - 20251217 PL - England TA - Psychoneuroendocrinology JT - Psychoneuroendocrinology JID - 7612148 RN - 0 (Cytokines) RN - 0 (Interleukin-6) RN - 0 (Lipopolysaccharides) RN - 0 (Interleukin-1beta) RN - 82115-62-6 (Interferon-gamma) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Male MH - Young Adult MH - Students MH - Universities MH - Adolescent MH - *Inflammation/blood/metabolism/immunology MH - *Cytokines/blood/analysis MH - Interleukin-6/blood/analysis MH - Lipopolysaccharides/pharmacology MH - Interleukin-1beta/blood/analysis MH - Interferon-gamma/blood/analysis MH - Biomarkers/blood PMC - PMC12809777 MID - NIHMS2130853 OTO - NOTNLM OT - Immune function OT - Inflammation OT - Stimulated cytokine production OT - University students COIS- Declaration of Competing Interest none EDAT- 2025/12/20 21:50 MHDA- 2026/01/24 12:31 PMCR- 2026/01/17 CRDT- 2025/12/20 18:00 PHST- 2025/07/11 00:00 [received] PHST- 2025/10/22 00:00 [revised] PHST- 2025/12/15 00:00 [accepted] PHST- 2026/01/24 12:31 [medline] PHST- 2025/12/20 21:50 [pubmed] PHST- 2025/12/20 18:00 [entrez] PHST- 2026/01/17 00:00 [pmc-release] AID - S0306-4530(25)00452-4 [pii] AID - 10.1016/j.psyneuen.2025.107729 [doi] PST - ppublish SO - Psychoneuroendocrinology. 2026 Mar;185:107729. doi: 10.1016/j.psyneuen.2025.107729. Epub 2025 Dec 17. PMID- 41420717 OWN - NLM STAT- MEDLINE DCOM- 20260407 LR - 20261009 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 1 DP - 2025 Dec 20 TI - Normative reference values and factorial structure of the fundamental motor competence in Spanish preschoolers: implications for early pediatric assessment and intervention. PG - 29 LID - 10.1007/s00431-025-06663-y [doi] AB - The MOBAK-KG battery is a widely used tool for assessing motor skills in kindergartens. However, no normative data exists for Spanish-speaking children in Spain. The purpose of this study was two-fold: to develop normative reference values for the MOBAK-KG battery stratified by sex and age in children aged 4-6 years and to evaluate the factorial structure of the MOBAK-KG battery. This cross-sectional study enrolled 375 Spanish children (51.5% female). Smoothed percentile for object-movement, self-movement, and total MOBAK-KG scores were calculated using the LMS method, incorporating the gamma-lambda, mu-mu, and delta-sigma parameters according to age and sex, and confirmatory factor analysis was performed to determine the construct validity. Fit indices and parameter estimates were reported. The MOBAK-KG battery (observable items) that cover the object movement and self-movement motor competencies (latent factors) were consistently higher in boys than in girls and increased across age groups for both sexes. The results confirm the structure of the one-factor model provided the best representation of the data (chi(2)/df ratio = 1.09, CFI = 0.997; RMSEA = 0.016), and the structure of the two-factor model in all sections of the MOBAK battery also demonstrated acceptable fit (chi(2)/df = 1.33, CFI = 0.972; RMSEA = 0.036). CONCLUSION: This is the first study to provide normative MOBAK-KG data for preschool children in Spain, based on a representative sample from Northern Spain. Our results suggest that the MOBAK-KG is a valid tool to assess fundamental motor competence in children in Spain. These normative data provide pediatricians and educators with objective benchmarks to identify children at risk of motor deficits. WHAT IS KNOWN: * Fundamental motor skills (FMS) are essential for children's development and for sustaining lifelong physical activity. * MOBAK-KG is a validated tool for preschool motor competence, but normative data and structure have mainly come from German/Swiss cohorts, limiting use in Spain. WHAT IS NEW: * We provide the first Spanish norms for MOBAK-KG (ages 4-6) and confirm its psychometric structure: the one-factor model fits best, while the two-factor (OM/SM) solution remains useful for domain profiling. * We quantified age-related gains and modest sex differences and provided percentile cut-offs to support screening and early pediatric assessment and intervention. CI - (c) 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Alonso-Martinez, Loreto AU - Alonso-Martinez L AD - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Avenida de Baranain s/n, 31008, Pamplona, Navarra, Spain. FAU - Ramirez-Velez, Robinson AU - Ramirez-Velez R AD - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Avenida de Baranain s/n, 31008, Pamplona, Navarra, Spain. FAU - Legarra-Gorgonon, Gaizka AU - Legarra-Gorgonon G AD - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Avenida de Baranain s/n, 31008, Pamplona, Navarra, Spain. FAU - Garcia-Alonso, Yesenia AU - Garcia-Alonso Y AD - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Avenida de Baranain s/n, 31008, Pamplona, Navarra, Spain. FAU - Izquierdo, Mikel AU - Izquierdo M AD - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Avenida de Baranain s/n, 31008, Pamplona, Navarra, Spain. mikel.izquierdo@gmail.com. FAU - Alonso-Martinez, Alicia AU - Alonso-Martinez A AD - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Avenida de Baranain s/n, 31008, Pamplona, Navarra, Spain. LA - eng PT - Journal Article PT - Validation Study DEP - 20251220 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Reference Values MH - Factor Analysis, Statistical MH - Spain MH - *Motor Skills/classification MH - Humans MH - Male MH - Female MH - Child, Preschool MH - Child MH - Reproducibility of Results MH - Functional Status MH - *Physical Examination/methods/standards/statistics & numerical data MH - Child Development/physiology MH - Developmental Disabilities/diagnosis MH - *Pediatrics/instrumentation/methods/standards/statistics & numerical data MH - Reference Standards MH - *Psychometrics/instrumentation/standards/statistics & numerical data MH - Sex Factors OTO - NOTNLM OT - Factorial analysis OT - MOBAK-KG OT - Motor development OT - Motor skills OT - Preschool children OT - Reference values COIS- Declarations. Ethics approval: We obtained informed consent from parents or guardians, and children provided informed permission before participating. The study protocol adhered to the principles outlined in the Helsinki Declaration and received approval from the Ethics Committee of the Universidad Publica de Navarra (PI-020/19). Consent to participate: We obtained informed consent from parents or guardians, and children provided informed permission before participating. Competing interests: The authors declare no competing interests. EDAT- 2025/12/20 12:31 MHDA- 2025/12/20 12:32 CRDT- 2025/12/20 11:07 PHST- 2025/06/17 00:00 [received] PHST- 2025/11/21 00:00 [accepted] PHST- 2025/11/18 00:00 [revised] PHST- 2025/12/20 12:32 [medline] PHST- 2025/12/20 12:31 [pubmed] PHST- 2025/12/20 11:07 [entrez] AID - 10.1007/s00431-025-06663-y [pii] AID - 10.1007/s00431-025-06663-y [doi] PST - epublish SO - Eur J Pediatr. 2025 Dec 20;185(1):29. doi: 10.1007/s00431-025-06663-y. PMID- 41419065 OWN - NLM STAT- MEDLINE DCOM- 20260104 LR - 20260104 IS - 1573-2517 (Electronic) IS - 0165-0327 (Linking) VI - 397 DP - 2026 Mar 15 TI - The configurational influence mechanism of risky behaviors among adolescents: A combined effect analysis of neuroticism, depression, anxiety, eating behavior, alcohol consumption, and quality of life. PG - 120917 LID - S0165-0327(25)02359-6 [pii] LID - 10.1016/j.jad.2025.120917 [doi] AB - BACKGROUND: This study is based on data from the 2021 China Residents' Mental Health and Behavioral Survey (PBICR) conducted by the School of Public Health at Peking University. It focuses on the multifaceted mechanisms underlying adolescent health-risk behaviors, overcoming the explanatory limitations of traditional linear models, and exploring the asymmetric interactions between risk and protective factors. METHODS: A full sample of 560 middle school students (59.7 % female, 74.7 % urban) was used. Four-stage analysis was conducted: t-tests/chi-square tests to reveal demographic differences; Pearson correlation analysis to assess variable associations; structural equation modeling to validate path effects; and fuzzy set qualitative comparative analysis (fsQCA) to identify conditional configurations. RESULTS: Males had higher health-related quality of life (p = 0.027) and significantly higher drinking rates (p = 0.004). Health-related quality of life was the core protective factor (beta = -0.199), with depression exhibiting both direct (beta = 0.243) and mediating (beta = 0.085) pathways. fsQCA identified four configurations: high-risk groups driven by depression + alcohol consumption, and low-risk groups with foundational protective factors (dominated by health-related quality of life) + enhanced protective factors (health-related quality of life + high neuroticism). CONCLUSION: This study indicates that a higher quality of healthy living serves as a core protective factor against adolescent health risks, while depression and alcohol consumption form overlapping risks. Accordingly, it is recommended to establish a three-tiered prevention system: implement universal health education programs, conduct targeted interventions for depression and alcohol-related issues, and utilize digital tools to dynamically monitor changes in healthy living quality and risk factors, thereby achieving precision prevention. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Yang, Li AU - Yang L AD - School of Management, Shandong Second Medical University, No.7166 Baotong West Street, Weifang, Shandong, 261053, China. FAU - Zhu, Shuai-Hao AU - Zhu SH AD - School of Management, Shandong Second Medical University, No.7166 Baotong West Street, Weifang, Shandong, 261053, China. FAU - Zhang, Yi AU - Zhang Y AD - Affiliated Hospital of Shandong Second Medical University, No. 2428 Yuhe Road, Weifang, Shandong, 261033, China. FAU - Zhang, Ju-Feng AU - Zhang JF AD - School of Management, Shandong Second Medical University, No.7166 Baotong West Street, Weifang, Shandong, 261053, China. FAU - Wang, Dan AU - Wang D AD - School of Basic Medical Sciences, Shandong Second Medical University, No.7166 Baotong West Street, Weifang, Shandong, 261053, China. Electronic address: helloyangli@163.com. LA - eng PT - Journal Article DEP - 20251217 PL - Netherlands TA - J Affect Disord JT - Journal of affective disorders JID - 7906073 SB - IM MH - Humans MH - Female MH - Male MH - Adolescent MH - *Quality of Life/psychology MH - *Neuroticism MH - China/epidemiology MH - *Depression/psychology/epidemiology MH - *Risk-Taking MH - *Alcohol Drinking/psychology/epidemiology MH - *Anxiety/psychology/epidemiology MH - *Feeding Behavior/psychology MH - *Adolescent Behavior/psychology OTO - NOTNLM OT - Anxiety OT - Big Five personality traits OT - Depression OT - Healthy risk behaviors COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/12/20 00:40 MHDA- 2026/01/05 00:49 CRDT- 2025/12/19 19:34 PHST- 2025/09/07 00:00 [received] PHST- 2025/11/27 00:00 [revised] PHST- 2025/12/13 00:00 [accepted] PHST- 2026/01/05 00:49 [medline] PHST- 2025/12/20 00:40 [pubmed] PHST- 2025/12/19 19:34 [entrez] AID - S0165-0327(25)02359-6 [pii] AID - 10.1016/j.jad.2025.120917 [doi] PST - ppublish SO - J Affect Disord. 2026 Mar 15;397:120917. doi: 10.1016/j.jad.2025.120917. Epub 2025 Dec 17. PMID- 41417346 OWN - NLM STAT- MEDLINE DCOM- 20251219 LR - 20260420 IS - 1984-0446 (Electronic) IS - 0034-7167 (Print) IS - 0034-7167 (Linking) VI - 78 IP - 5 DP - 2025 TI - Psychometric Properties of the Brazilian Version of the Eating Attitudes Test in University Students. PG - e20240582 LID - S0034-71672025000500171 [pii] LID - 10.1590/0034-7167-2024-0582 [doi] LID - e20240582 AB - OBJECTIVES: to evaluate the psychometric properties of the Brazilian version of the Eating Attitudes Test among university students and to analyze potential differences between sexes. METHODS: a methodological, quantitative study was conducted with 5,292 students. Data were collected through an online questionnaire comprising 26 Likert-scale items, including sociodemographic, academic, and health-related questions. The psychometric properties assessed included factorial validity, internal consistency, psychometric sensitivity, and structural equivalence between groups. RESULTS: confirmatory factor analysis supported the multidimensional structure of the instrument, with satisfactory fit indices. The chi-square statistic was 14,447.944 with 296 degrees of freedom (p < 0.001), chi-square/df ratio of 48.81, comparative fit index of 0.843, Tucker-Lewis index of 0.828, root mean square error of approximation of 0.095, and standardized root mean square residual of 0.125. Structural equivalence was observed between sexes. CONCLUSIONS: the instrument demonstrated robust factorial validity for use among Brazilian university students. FAU - Coelho, Manuela de Mendonca Figueiredo AU - Coelho MMF AUID- ORCID: 0000-0001-6182-9486 AD - Universidade Federal do Ceara. Fortaleza, Ceara, Brazil. FAU - Castro, Tifanny Horta AU - Castro TH AUID- ORCID: 0000-0002-3620-8394 AD - Universidade Federal do Ceara. Fortaleza, Ceara, Brazil. FAU - Oliveira, Beatriz Alves de AU - Oliveira BA AUID- ORCID: 0000-0002-1171-5031 AD - Universidade Federal do Ceara. Fortaleza, Ceara, Brazil. FAU - Diniz, Jamylle Lucas AU - Diniz JL AUID- ORCID: 0000-0002-5697-8599 AD - Universidade Federal do Ceara. Fortaleza, Ceara, Brazil. FAU - Martins, Mariana Cavalcante AU - Martins MC AUID- ORCID: 0009-0006-8133-0141 AD - Universidade Federal do Ceara. Fortaleza, Ceara, Brazil. FAU - Coutinho, Janaina Fonseca Victor AU - Coutinho JFV AUID- ORCID: 0000-0001-7451-0132 AD - Universidade Federal do Ceara. Fortaleza, Ceara, Brazil. FAU - Gubert, Fabiane do Amaral AU - Gubert FDA AUID- ORCID: 0000-0003-3016-9619 AD - Universidade Federal do Ceara. Fortaleza, Ceara, Brazil. FAU - Oria, Monica Oliveira Batista AU - Oria MOB AUID- ORCID: 0000-0002-1483-6656 AD - Universidade Federal do Ceara. Fortaleza, Ceara, Brazil. LA - eng LA - por PT - Journal Article DEP - 20251219 PL - Brazil TA - Rev Bras Enferm JT - Revista brasileira de enfermagem JID - 7910105 SB - IM MH - Humans MH - *Psychometrics/methods/instrumentation/standards MH - Brazil MH - Female MH - Male MH - *Students/psychology/statistics & numerical data MH - Universities/organization & administration/statistics & numerical data MH - Surveys and Questionnaires MH - Reproducibility of Results MH - Adult MH - Young Adult MH - Adolescent MH - *Feeding Behavior/psychology MH - Factor Analysis, Statistical PMC - PMC12716680 EDAT- 2025/12/19 18:32 MHDA- 2025/12/19 18:33 PMCR- 2025/12/19 CRDT- 2025/12/19 12:03 PHST- 2024/12/12 00:00 [received] PHST- 2025/05/14 00:00 [accepted] PHST- 2025/12/19 18:33 [medline] PHST- 2025/12/19 18:32 [pubmed] PHST- 2025/12/19 12:03 [entrez] PHST- 2025/12/19 00:00 [pmc-release] AID - S0034-71672025000500171 [pii] AID - 10.1590/0034-7167-2024-0582 [doi] PST - epublish SO - Rev Bras Enferm. 2025 Dec 19;78(5):e20240582. doi: 10.1590/0034-7167-2024-0582. eCollection 2025. PMID- 41417242 OWN - NLM STAT- MEDLINE DCOM- 20251219 LR - 20261009 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 1 DP - 2025 Dec 19 TI - Is chronotype associated with ultra-processed food consumption in adolescents? Results from the EHDLA study. PG - 27 LID - 10.1007/s00431-025-06574-y [doi] AB - The consumption of ultra-processed foods (UPFs) among adolescents has risen sharply, contributing to poor dietary quality and adverse health outcomes. Chronotype, an individual's preference for morning or evening activity, has been linked to lifestyle behaviors, but its association with UPF intake in adolescents remains unclear. This study aimed to examine whether chronotype is associated with UPF consumption in a representative sample of Spanish adolescents. A cross-sectional analysis was conducted using data from 820 adolescents aged 12-17 years participating in the Eating Healthy and Daily Life Activities (EHDLA) study in Murcia, Spain. Chronotype was assessed with the Morningness/Eveningness Scale for Children (MESC). UPF consumption was measured via a validated food frequency questionnaire and classified according to the NOVA system. Associations between chronotype categories (eveningness, intermediate, morningness) and UPF intake were analyzed using robust generalized linear models, adjusting for sociodemographic and lifestyle covariates. Adolescents with an evening chronotype had the highest predicted UPF consumption (34.7 servings/week; 95% confidence interval [CI] 33.0 to 36.3), followed by those with an intermediate chronotype (33.4; 95% CI 32.6 to 34.1), and those with a morning type (31.9; 95% CI 31.0 to 32.8). Pairwise comparisons showed that morning types consumed less UPFs than evening types (difference = -2.8; 95% CI -4.7 to -0.8; p = 0.005). Furthermore, a significant distinction was observed between the intermediate and morning chronotype groups (-1.4; 95% CI -2.6 to -0.3; p = 0.018). CONCLUSIONS: Adolescents with an evening chronotype show higher UPF consumption than those with morning or intermediate chronotypes, even after adjusting for key sociodemographic, anthropometric, and lifestyle factors. These findings suggest that chronotype status may influence unhealthy eating behaviors, highlighting the need for chronotype-tailored interventions to reduce UPF intake in this vulnerable population. WHAT IS KNOWN: * The consumption of ultra-processed foods (UPFs) in children and adolescents is linked to higher risks of obesity, metabolic disorders, and chronic diseases. UPFs are rich in calories, sugars, and unhealthy fats, undermining diet quality. Studies report a dose-response relationship between UPF intake and overweight/obesity risk, supporting urgent preventive measures. WHAT IS NEW: * Emerging research connects chronotype (a person's biological timing preference for activities) with dietary habits. Evening chronotypes tend to consume more UPFs, engage in late-night eating, and have a poorer diet quality. This study reveals that Spanish adolescents with an evening chronotype consume significantly more UPFs than those with morning or intermediate chronotypes, highlighting potential targets for public health strategies. CI - (c) 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Aquino-Blanco, Andrea AU - Aquino-Blanco A AD - Health and Social Research Center, Universidad de Castilla-La Mancha, Cuenca, Spain. FAU - Quiroz-Cardenas, Fiorella AU - Quiroz-Cardenas F AD - Universidad Autonoma del Paraguay, Asuncion, Paraguay. FAU - Yanez-Sepulveda, Rodrigo AU - Yanez-Sepulveda R AD - Faculty Education and Social Sciences, Universidad Andres Bello, Vina del Mar, Chile. FAU - Gutierrez-Espinoza, Hector AU - Gutierrez-Espinoza H AD - Faculty of Education, Universidad Autonoma de Chile, Santiago de Chile, Chile. FAU - Olivares-Arancibia, Jorge AU - Olivares-Arancibia J AD - AFySE Group, Research in Physical Activity and School Health, School of Physical Education, Faculty of Education, Universidad de Las Americas, Santiago, Chile. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AD - School of Medicine, Universidad Espiritu Santo, Samborondon, Ecuador. josefranciscolopezgil@gmail.com. AD - Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno, Chile. josefranciscolopezgil@gmail.com. LA - eng PT - Journal Article DEP - 20251219 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - Cross-Sectional Studies MH - Child MH - *Fast Foods/statistics & numerical data MH - *Feeding Behavior MH - Spain MH - *Circadian Rhythm MH - Life Style MH - Food, Processed MH - Chronotype OTO - NOTNLM OT - Adolescents OT - Chronotype OT - Circadian rhythms OT - Dietary patterns OT - Eating behavior OT - Spain OT - Ultra-processed foods COIS- Declarations. Informed consent: All participants and their legal guardians provided informed consent. Competing interest: The authors declare no competing interests. Institutional review board: The study received ethical approval from the Bioethics Committee at the University of Murcia (ID 2218/2018) and from the Ethics Committee of the Complejo Hospitalario Universitario de Albacete and the Integrated Care Management of Albacete (ID 2021-86). All procedures followed the ethical standards established by the World Medical Association in the Declaration of Helsinki. EDAT- 2025/12/19 15:02 MHDA- 2025/12/19 15:03 CRDT- 2025/12/19 11:27 PHST- 2025/06/20 00:00 [received] PHST- 2025/10/14 00:00 [accepted] PHST- 2025/10/12 00:00 [revised] PHST- 2025/12/19 15:03 [medline] PHST- 2025/12/19 15:02 [pubmed] PHST- 2025/12/19 11:27 [entrez] AID - 10.1007/s00431-025-06574-y [pii] AID - 10.1007/s00431-025-06574-y [doi] PST - epublish SO - Eur J Pediatr. 2025 Dec 19;185(1):27. doi: 10.1007/s00431-025-06574-y. PMID- 41417229 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260919 IS - 1436-6215 (Electronic) IS - 1436-6207 (Print) IS - 1436-6207 (Linking) VI - 65 IP - 1 DP - 2025 Dec 19 TI - EAT-Lancet reference diet and nutritional adequacy in children: examining the planetary health diet index for children (PHDI-C). PG - 16 LID - 10.1007/s00394-025-03858-9 [doi] LID - 16 AB - PURPOSE: The EAT-Lancet Commission introduced a Planetary Health Diet (PHD) in 2019 for individuals aged two years and older. Concerns exist regarding its ability to fulfill children's specific micronutrient requirements. The PHDI-C, an adapted version of the Planetary Health Diet Index (PHDI), was developed to better reflect the nutritional needs of growing children. However, its association with micronutrient adequacy in pediatric populations has not been fully examined. Our study investigates whether the PHDI-C is associated with micronutrient adequacy in children and compares its performance to the original PHDI. METHODS: This cross-sectional study compared the association of the PHDI and PHDI-C with nutritional adequacy in 945 children aged 4-5 years from the SENDO cohort. Dietary, lifestyle, and socio-demographic data were collected via parent-administered questionnaires. Dietary intake was assessed using a Food Frequency Questionnaire (FFQ). Scores for both indices were calculated and ranged from 0 to 150, and participants were categorized into tertiles. We calculated the intake of 20 micronutrients relevant to public health and micronutrient adequacy was assessed using the Estimated Average Requirement (EAR) cut-off points. Generalized estimating equation models were used to examine the relationship between both indices and the risk of inadequate micronutrient intake. RESULTS: Median scores were 63.0 and 62.3 for the PHDI and PHDI-C respectively. Higher PHDI and PHDI-C scores were associated with higher intakes of vitamins A, C, E, B1, B3, and B6, as well as folate, Fe, Mg, Se, Zn, Cr, and K, but lower intakes of vitamins B2, B12, and Ca, and I. After adjusting for potential confounders, higher PHDI-C scores were associated with fewer unmet EARs (p < 0.001). Children in the highest tertile of the PHDI-C had 55% lower odds (OR:0.45 95% CI: 0.22-0.94) of having >/= 3 inadequate micronutrient intakes compared to the lowest tertile. For the original PHDI, children in the highest tertile had 30% lower odds (OR: 0.70; 95% CI: 0.32-1.54). CONCLUSION: The PHDI-C is linked to better nutritional adequacy than the original PHDI. Further research is needed to validate the PHDI-C in terms of environmental sustainability. FAU - Fabios, Elise AU - Fabios E AD - Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, Pamplona, Spain. FAU - Zazpe, Itziar AU - Zazpe I AD - Department of Nutrition, Food Science and Physiology, School of Pharmacy, University of Navarra, Pamplona, Spain. AD - Biomedical Research Centre Network on Obesity and Nutrition (CIBERobn), Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain. AD - IdiSNA, Instituto de Investigacion Sanitaria de Navarra, Pamplona, Spain. FAU - Santiago, Susana AU - Santiago S AD - Department of Nutrition, Food Science and Physiology, School of Pharmacy, University of Navarra, Pamplona, Spain. AD - IdiSNA, Instituto de Investigacion Sanitaria de Navarra, Pamplona, Spain. FAU - Garcia, Silvia AU - Garcia S AD - Biomedical Research Centre Network on Obesity and Nutrition (CIBERobn), Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain. AD - Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, Palma de Mallorca, Spain. AD - Health Research Institute of the Balearic Islands (IdISBa), Palma de Mallorca, Spain. FAU - Martinez-Gonzalez, Miguel Angel AU - Martinez-Gonzalez MA AD - Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, Pamplona, Spain. AD - Biomedical Research Centre Network on Obesity and Nutrition (CIBERobn), Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain. AD - IdiSNA, Instituto de Investigacion Sanitaria de Navarra, Pamplona, Spain. FAU - Martin-Calvo, Nerea AU - Martin-Calvo N AUID- ORCID: 0000-0001-7549-1455 AD - Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, Pamplona, Spain. nmartincalvo@unav.es. AD - Biomedical Research Centre Network on Obesity and Nutrition (CIBERobn), Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain. nmartincalvo@unav.es. AD - IdiSNA, Instituto de Investigacion Sanitaria de Navarra, Pamplona, Spain. nmartincalvo@unav.es. LA - eng PT - Journal Article DEP - 20251219 PL - Germany TA - Eur J Nutr JT - European journal of nutrition JID - 100888704 RN - 0 (Micronutrients) SB - IM MH - Humans MH - Child, Preschool MH - Cross-Sectional Studies MH - Male MH - Female MH - *Micronutrients/administration & dosage MH - *Nutritional Status MH - *Diet, Healthy/statistics & numerical data MH - Nutritional Requirements MH - *Diet MH - *Child Nutritional Physiological Phenomena MH - *Recommended Dietary Allowances PMC - PMC12717126 OTO - NOTNLM OT - EAT-Lancet diet OT - Micronutrient adequacy OT - PHDI-C OT - Planetary health diet index OT - SENDO Cohort COIS- Declarations. Conflict of interest: The authors declare that they have no competing interests. Ethical approval: The SENDO project adheres to the rules of the Declaration of Helsinki on the ethical principles for medical research in human beings. This study was approved by the Ethics Committee for Clinical Research of Navarra (P. 2016/122). An informed consent was obtained during the recruitment from all participants' parents. Consent for publication: Not applicable. EDAT- 2025/12/19 15:03 MHDA- 2026/06/27 00:49 PMCR- 2025/12/19 CRDT- 2025/12/19 11:26 PHST- 2025/05/13 00:00 [received] PHST- 2025/11/25 00:00 [accepted] PHST- 2026/06/27 00:49 [medline] PHST- 2025/12/19 15:03 [pubmed] PHST- 2025/12/19 11:26 [entrez] PHST- 2025/12/19 00:00 [pmc-release] AID - 10.1007/s00394-025-03858-9 [pii] AID - 3858 [pii] AID - 10.1007/s00394-025-03858-9 [doi] PST - epublish SO - Eur J Nutr. 2025 Dec 19;65(1):16. doi: 10.1007/s00394-025-03858-9. PMID- 41413499 OWN - NLM STAT- MEDLINE DCOM- 20260124 LR - 20260125 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2025 Dec 18 TI - Measuring screen time among adolescents: test-retest reliability of HBSC questionnaire items across two countries. PG - 290 LID - 10.1186/s12889-025-25950-9 [doi] LID - 290 AB - BACKGROUND: Increasing recreational screen time among adolescents is linked to adverse health outcomes like obesity and poor mental health. This highlights the need for reliable tools to monitor screen-based behaviours. The present study examined the test-retest reliability of recreational screen-time items from the Health Behaviour in School-aged Children (HBSC) questionnaire across culturally diverse adolescent populations. METHODS: Using a test-retest design with a 2-3 week interval, we collected data from 750 adolescents (48.8% boys, mean age 15.29 years, SD 2.37) in Mexico (n = 233, aged 10-15y) and Czechia (n = 517, aged 10-18y) in 2022-2024. Self-reported time spent on gaming, social networking, video watching, and internet browsing were evaluated using Intraclass Correlation Coefficients (ICCs) for continuous measures and Cohen's kappa for dichotomized outcomes (< 2 vs. >/= 2 h/day), with analyses stratified by age, gender, and country. RESULTS: Gaming and social networking demonstrated moderate-to-good reliability (ICC = 0.70-0.74, kappa = 0.64-0.65, 82-83% unchanged responses). Video watching and browsing were less stable (ICC = 0.52-0.63, kappa = 0.41-0.47). Czech primary school students exhibited the highest consistency (ICC = 0.76-0.81), while Mexican students completed the items with lower reliability (ICC = 0.43-0.54). Older adolescents (16-18 years) and girls reported greater stability for gaming and social networking, respectively. CONCLUSIONS: The screen-time items tested in this study showed acceptable test-retest reliability across countries, age groups, and sexes, particularly for gaming and social networking. These findings support their use in global adolescent health surveillance, while highlighting the need for refinement of less stable domains such as video watching and internet browsing. Given that samples were not nationally representative, findings should be interpreted within these specific contexts. Future research should enhance measurement precision and inform public health efforts to monitor and address screen-time related health risks. CI - (c) 2025. The Author(s). FAU - Matusova, Michaela AU - Matusova M AD - Faculty of Physical Culture, Palacky University Olomouc, Olomouc, Czech Republic. FAU - Maracek, Marek AU - Maracek M AD - Faculty of Physical Culture, Palacky University Olomouc, Olomouc, Czech Republic. FAU - Pavelka, Jan AU - Pavelka J AD - Centre of Sports Activities, Brno University of Technology, Brno, Czech Republic. FAU - Ng, Kwok AU - Ng K AD - Physical Activity for Health Research Centre, Department of Physical Education and Sport Sciences, Health Research Institute, University of Limerick, Limerick, Ireland. AD - Faculty of Education, University of Turku, Turku, Finland. AD - Institute of Sports Science and Innovation, Lithuanian Sports University, Kaunas, Lithuania. FAU - Medina, Catalina AU - Medina C AD - National Institute of Public Health, Cuernavaca, Morelos, Mexico. FAU - Tylsarova, Nikola AU - Tylsarova N AD - Faculty of Physical Culture, Palacky University Olomouc, Olomouc, Czech Republic. FAU - Bucksch, Jens AU - Bucksch J AD - Department of Prevention and Health Promotion, Faculty of Natural and Social Sciences, Heidelberg University of Education, Heidelberg, Germany. FAU - Hamrik, Zdenek AU - Hamrik Z AD - Faculty of Physical Culture, Palacky University Olomouc, Olomouc, Czech Republic. zdenek.hamrik@hbsc.org. LA - eng GR - IGA_FTK_2024_010/Internal Grant Agency of Palacky University Olomouc/ GR - IGA_FTK_2025_015/Internal Grant Agency of Palacky University Olomouc/ PT - Journal Article DEP - 20251218 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - Reproducibility of Results MH - Child MH - *Screen Time MH - Surveys and Questionnaires/standards MH - Mexico MH - Czech Republic MH - *Adolescent Behavior MH - Video Games/statistics & numerical data PMC - PMC12829222 OTO - NOTNLM OT - Children OT - HBSC OT - Psychometrics OT - Questionnaire reliability OT - Screen time COIS- Declarations. Ethics approval and consent to participate: The Mexican study was reviewed and approved by the Ethics Committee at the National Institute of Public Health. In Czechia the study was approved by Ethics Committee of the Faculty of Physical Culture Palacky University in Olomouc (11/2022- high school cohort; 57/2024-primary school cohort). Participation in the study was anonymous and voluntary, and no incentives were offered. Informed consent to participate was obtained from all study participants. For any participants under the age of 16, informed consent was obtained from their parents or legal guardians. In Mexico, the main objectives and procedures of the study were explained to parents, and informed consent was obtained from parents alongside assent from adolescents before data collection. In the Czech Republic, adolescents aged 16 years and older provided their own informed consent. For participants younger than 16 years, informed consent was obtained from parents or legal guardians, either directly for this survey or via the school's general informed consent procedure signed at the beginning of the school year, on the basis of which school principals confirmed participation. Prior to data collection, adolescents were informed that participation was voluntary and that they could skip any questions or withdraw at any time without consequences. All procedures were carried out in accordance with the ethical standards of the institutional research committees and with the 1964 Helsinki Declaration and its later amendments. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/19 01:45 MHDA- 2026/01/24 09:38 PMCR- 2025/12/18 CRDT- 2025/12/18 23:49 PHST- 2025/08/22 00:00 [received] PHST- 2025/12/05 00:00 [accepted] PHST- 2026/01/24 09:38 [medline] PHST- 2025/12/19 01:45 [pubmed] PHST- 2025/12/18 23:49 [entrez] PHST- 2025/12/18 00:00 [pmc-release] AID - 10.1186/s12889-025-25950-9 [pii] AID - 25950 [pii] AID - 10.1186/s12889-025-25950-9 [doi] PST - epublish SO - BMC Public Health. 2025 Dec 18;26(1):290. doi: 10.1186/s12889-025-25950-9. PMID- 41410487 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251218 LR - 20260926 IS - 2045-7022 (Print) IS - 2045-7022 (Electronic) IS - 2045-7022 (Linking) VI - 15 IP - 12 DP - 2025 Dec TI - Associations Between the Maternal Diet Index and Childhood Asthma: The NorthPop and Healthy Start Cohorts. PG - e70144 LID - 10.1002/clt2.70144 [doi] LID - e70144 AB - BACKGROUND: A novel maternal diet index (MDI), characterizing offspring asthma- and allergy-associated maternal intake during pregnancy was constructed and validated in Healthy Start, USA. This study aims to (1) externally validate the asthma findings from Healthy Start in the NorthPop Birth Cohort Study (NorthPop) in Sweden; and (2) characterize the diet and demographics of the two cohorts. METHODS: The MDI was computed as a weighted combination of seven components associated with offspring allergies and asthma, including vegetables and yogurt (associated with decreased odds) and cold cereals, fried potatoes, juice, red meat, and rice (associated with increased odds). Doctor diagnoses provided childhood asthma incidence and timing. Parametric Weibull time-to-event analysis evaluated associations between the MDI, dichotomized at the median (72.2) for Healthy Start, and offspring asthma. RESULTS: The NorthPop and Healthy Start mean MDI values differed significantly (p < 0.001) and in NorthPop, only 6.1% had MDI < 72.2. Data from 6446 mother-child dyads in NorthPop yielded a crude hazard ratio (HR) for asthma of 0.70 (95% confidence interval [CI] 0.50-0.98, p = 0.037) and a fully adjusted HR of 0.84 (0.55-1.29; p = 0.428) for MDI > 72.2 versus < 72.2 (n = 4655). The fully adjusted HR for 945 Healthy Start dyads was significant at HR 0.41 (0.29-0.57; p < 0.0001). CONCLUSIONS: Results show that in a population with different maternal dietary patterns and demographics compared to the source population, MDI > 72.2 was not an independent predictor of offspring asthma. Further proof of the utility and generalizability of the MDI needs to be tested in other populations. CI - (c) 2025 The Author(s). Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology. FAU - Boden, Stina AU - Boden S AUID- ORCID: 0000-0002-8958-975X AD - Department of Clinical Sciences, Pediatrics, Umea University, Umea, Sweden. AD - Section of Allergy & Immunology, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado, USA. FAU - Venter, Carina AU - Venter C AUID- ORCID: 0000-0002-7473-5355 AD - Section of Allergy & Immunology, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado, USA. AD - Children's Hospital Colorado, Aurora, Colorado, USA. FAU - Pickett-Nairne, Kaci AU - Pickett-Nairne K AUID- ORCID: 0009-0000-1451-0229 AD - Department of Pediatrics, University of Colorado School of Medicine, University of Colorado Denver, Aurora, Colorado, USA. FAU - Glueck, Deborah H AU - Glueck DH AUID- ORCID: 0000-0003-0047-8939 AD - Department of Pediatrics, University of Colorado School of Medicine, University of Colorado Denver, Aurora, Colorado, USA. FAU - Lundberg-Ulfsdotter, Richard AU - Lundberg-Ulfsdotter R AUID- ORCID: 0000-0003-0399-4189 AD - Department of Clinical Sciences, Pediatrics, Umea University, Umea, Sweden. FAU - Domellof, Magnus AU - Domellof M AUID- ORCID: 0000-0002-0726-7029 AD - Department of Clinical Sciences, Pediatrics, Umea University, Umea, Sweden. FAU - Dabelea, Dana AU - Dabelea D AUID- ORCID: 0000-0001-9514-8929 AD - Department of Pediatrics, University of Colorado School of Medicine, University of Colorado Denver, Aurora, Colorado, USA. AD - Lifecourse Epidemiology of Adiposity and Diabetes Center, University of Colorado Anschutz Medical Campus, University of Colorado Denver, Aurora, Colorado, USA. AD - Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado, USA. FAU - West, Christina E AU - West CE AUID- ORCID: 0000-0001-9599-2580 AD - Department of Clinical Sciences, Pediatrics, Umea University, Umea, Sweden. LA - eng GR - RV 840681/Vasterbotten County Council/ GR - UG3 OD023248/OD/NIH HHS/United States/NH/NIH HHS/United States GR - RV-960756/Vasterbotten County Council/ GR - JLL-993810/Unit of Research, Region Jamtland Harjedalen Foundation/ GR - Swedish Foundation for International Cooperation in Research and Higher Education/ GR - Vetenskapsradet/ GR - Forte government agency/ GR - R01 GM121081/GM/NIGMS NIH HHS/United States/NH/NIH HHS/United States GR - RV 832441/Vasterbotten County Council/ GR - R25GM111901-S1/NH/NIH HHS/United States GR - R25 GM111901/GM/NIGMS NIH HHS/United States GR - 2018-02642/Swedish Research Council/ GR - UH3 OD023248/OD/NIH HHS/United States/NH/NIH HHS/United States GR - JLL-993235/Unit of Research, Region Jamtland Harjedalen Foundation/ GR - Umea University's strategic research funds/ GR - R01 DK076648/DK/NIDDK NIH HHS/United States GR - 2018-40/the Ekhaga Foundation/ GR - R01 GM121081/GM/NIGMS NIH HHS/United States GR - UG3 OD023248/OD/NIH HHS/United States GR - R01 DK076648/DK/NIDDK NIH HHS/United States/NH/NIH HHS/United States GR - UH3 OD023248/OD/NIH HHS/United States GR - 2021-01367/Swedish Research Council/ GR - R25GM111901/NH/NIH HHS/United States GR - Henning och Johan Throne-Holst's foundation for the promotion of scientific research/ GR - 20180641/the Heart-Lung Foundation/ GR - Kempe Foundation/ PT - Journal Article PL - England TA - Clin Transl Allergy JT - Clinical and translational allergy JID - 101576043 PMC - PMC12713374 OTO - NOTNLM OT - MDI OT - asthma prevention OT - childhood allergic disease OT - maternal diet OT - nutrition COIS- Dr. Venter reports grants from Reckitt Benckiser Food Allergy Research and Education, National Peanut Board; personal fees from Reckitt Benckiser, Nestle Nutrition Institute, Danone, Abbott Nutrition, Else Nutrition, Before Brands and Owen outside the submitted work. Dr. West has received research funding from Thermo Fisher Scientific and Arla, which was directly paid to the institution, and speaker honoraria from Thermo Fisher Scientific, Aimmune Therapeutics, a Nestle Health Science company, and Nutricia outside the submitted work. The other authors declare no conflicts of interest. Dr. Domellof has received consultation honoraria or speaker fees Baxter Medical AB, Danone Nutricia, Elgan Pharma, Fresenius Kabi Deutschland GmbH, Intertek Health Sciences Inc. and Ipsen AB as well as a grant/research support from Arla Foods Ingredients. EDAT- 2025/12/18 13:07 MHDA- 2025/12/18 13:08 PMCR- 2025/12/18 CRDT- 2025/12/18 09:24 PHST- 2025/10/16 00:00 [revised] PHST- 2025/07/30 00:00 [received] PHST- 2025/12/02 00:00 [accepted] PHST- 2025/12/18 13:08 [medline] PHST- 2025/12/18 13:07 [pubmed] PHST- 2025/12/18 09:24 [entrez] PHST- 2025/12/18 00:00 [pmc-release] AID - CLT270144 [pii] AID - 10.1002/clt2.70144 [doi] PST - ppublish SO - Clin Transl Allergy. 2025 Dec;15(12):e70144. doi: 10.1002/clt2.70144. PMID- 41409704 OWN - NLM STAT- MEDLINE DCOM- 20251218 LR - 20251220 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Developing a socio-ecological framework for promoting physical activity among Chinese children and adolescents: a Delphi-AHP study. PG - 1700544 LID - 10.3389/fpubh.2025.1700544 [doi] LID - 1700544 AB - PURPOSE: Insufficient physical activity (PA) among children and adolescents poses a serious public health challenge in China, with over 84% failing to meet the World Health Organization's daily recommendations. Despite national policies promoting PA, a lack of localized, evidence-based frameworks has hindered effective implementation. METHOD: Guided by socio-ecological theory, a modified Delphi method was conducted with 17 experts across two rounds to refine framework dimensions and indicators. The Analytic Hierarchy Process (AHP) was then applied to calculate indicator weights. RESULTS: The final framework comprised four dimensions-school leadership, family involvement, community support, and societal collaboration-encompassing 17 primary indicators and 58 secondary indicators. Weight analysis highlighted schools as the most influential domain (54.37%), followed by families (23.14%), communities (12.11%), and societal collaboration (10.38%). CONCLUSION: This study is the first to establish a localized framework for PA promotion among Chinese children and adolescents, offering clear stakeholder responsibilities and weighted indicators to guide evidence-based interventions. While grounded in China's unique sociocultural setting, the methodology may inform similar efforts internationally. Future research should focus on empirical validation and development of standardized assessment tools based on this framework. CI - Copyright (c) 2025 Kong, Zhang, Chen, Zhang, Yang and Guo. FAU - Kong, Lin AU - Kong L AD - School of Physical Education, Guangdong University of Education, Guangzhou, Guangdong, China. FAU - Zhang, Xiqian AU - Zhang X AD - School of Physical Education, Guangdong University of Education, Guangzhou, Guangdong, China. FAU - Chen, Xinyu AU - Chen X AD - Department of Physical Education, College of Education for the Future, Beijing Normal University, Zhuhai, Guangdong, China. FAU - Zhang, Junkai AU - Zhang J AD - Department of Physical Education, College of Education for the Future, Beijing Normal University, Zhuhai, Guangdong, China. FAU - Yang, Yanguo AU - Yang Y AD - College of Physical Education, Shanghai Normal University, Shanghai, China. FAU - Guo, Mingming AU - Guo M AD - Department of Physical Education, College of Education for the Future, Beijing Normal University, Zhuhai, Guangdong, China. LA - eng PT - Journal Article DEP - 20251202 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - Chinese people SB - IM MH - Humans MH - Delphi Technique MH - Adolescent MH - China MH - *Exercise MH - Child MH - *Health Promotion/methods/organization & administration MH - Male MH - Female MH - Schools MH - East Asian People PMC - PMC12705577 OTO - NOTNLM OT - China OT - Delphi method OT - adolescents OT - analytic hierarchy process OT - children OT - physical activity OT - socio-ecological framework COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/18 07:20 MHDA- 2025/12/18 07:21 PMCR- 2025/12/02 CRDT- 2025/12/18 04:39 PHST- 2025/09/12 00:00 [received] PHST- 2025/10/29 00:00 [revised] PHST- 2025/11/12 00:00 [accepted] PHST- 2025/12/18 07:21 [medline] PHST- 2025/12/18 07:20 [pubmed] PHST- 2025/12/18 04:39 [entrez] PHST- 2025/12/02 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1700544 [doi] PST - epublish SO - Front Public Health. 2025 Dec 2;13:1700544. doi: 10.3389/fpubh.2025.1700544. eCollection 2025. PMID- 41409537 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251218 LR - 20251220 IS - 2164-2850 (Electronic) IS - 2164-2850 (Linking) VI - 13 IP - 1 DP - 2025 TI - Disordered eating, self-esteem, and physical activity among Tunisian adolescents: public health insights and validation of the Arabic Ede-Q. PG - 2601400 LID - 10.1080/21642850.2025.2601400 [doi] LID - 2601400 AB - BACKGROUND: Disordered eating behaviors are a growing public health concern among adolescents, with implications for both physical and psychological well-being. The availability of culturally valid assessment tools is critical for early identification and prevention. OBJECTIVES: This study aimed to (i) examine how self-esteem, sport participation, and Body Mass Index (BMI) predict eating disorder symptoms in a large cohort of Tunisian schoolchildren, and (ii) assess the psychometric properties of the Arabic version of the Eating Disorder Examination Questionnaire (EDE-Q). METHODS: A total of 1,748 adolescents (629 boys, 1119 girls; mean age approximately 16.8 years) from Zaghouan, Tunisia, completed self-report assessments of BMI, self-esteem (Rosenberg Self-Esteem Scale), physical and sports activity, and disordered eating (Arabic EDE-Q). Correlation, regression, and confirmatory factor analyses were conducted. RESULTS: Eating disorders were negatively associated with physical activity (boys: r = -0.456; girls: r = -0.260; p < 0.01) and self-esteem (beta = 0.651; p < 0.001) and positively associated with BMI (beta = 0.219; p < 0.001). The Arabic EDE-Q demonstrated a robust four-factor structure and high internal consistency (CFI = 0.996; RMSEA = 0.026). Gender differences were observed, with girls reporting higher disordered eating scores. CONCLUSIONS: Self-esteem and BMI are significant predictors of disordered eating, underscoring the need for integrated public health strategies that promote mental well-being and healthy body image among adolescents. The validated Arabic EDE-Q offers a reliable tool for screening and monitoring disordered eating in Arabic-speaking youth populations, enabling early intervention in school-based mental health programs. CI - (c) 2025 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. FAU - Azaiez, Fairouz AU - Azaiez F AD - High Institute of Sport and Physical Education of Gafsa, University of Gafsa, Gafsa, Tunisia. AD - Research Laboratory Education, Motricite, Sport et Sante, LR19JS01, High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, Tunisia. FAU - Ben Bechir, Sameh AU - Ben Bechir S AD - Research Laboratory Education, Motricite, Sport et Sante, LR19JS01, High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, Tunisia. AD - High Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef, Tunisia. FAU - Tannoubi, Amayra AU - Tannoubi A AD - High Institute of Sport and Physical Education of Gafsa, University of Gafsa, Gafsa, Tunisia. AD - Sports Performance Optimization Research Laboratory (LR09SEP01), National Center for Sports Medicine and Science (CNMSS), Tunis, Tunisia. FAU - Ceylan, Halil Ibrahim AU - Ceylan HI AD - Physical Education of Sports Teaching Department, Faculty of Sports Sciences, Ataturk University, Erzurum, Turkiye. FAU - Stefanica, Valentina AU - Stefanica V AD - Department of Physical Education and Sport, Faculty of Sciences, Physical Education and Informatics, National University of Science and Technology Politehnica Bucharest, Pitesti University Center, Pitesti, Romania. FAU - Boussayala, Ghada AU - Boussayala G AD - High Institute of Sport and Physical Education of Gafsa, University of Gafsa, Gafsa, Tunisia. AD - Research Laboratory Education, Motricite, Sport et Sante, LR19JS01, High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, Tunisia. FAU - Hagan, John Elvis AU - Hagan JE AD - Neurocognition and Action-Biomechanics-Research Group, Faculty of Psychology and Sports Science, Bielefeld University, Postfach, Bielefeld, Germany. AD - Department of Health, Physical Education and Recreation, University of Cape Coast, Cape Coast PMB, Ghana. FAU - Allihebi, Abdullah H AU - Allihebi AH AD - Department of Physical Education, College of Sport Sciences and Physical Activity, King Saud University, Riyadh, Saudi Arabia. FAU - Gawar, Abdulhafed Mabrouk AU - Gawar AM AD - Faculty of Physical Education and Sport Sciences of Tripoli, Universite of Tripoli, Tripoli, Libya. FAU - Farruh, Ahmedov AU - Farruh A AD - Samarkand State University, Department of Physical Education, Samarkand, Uzbekistan. FAU - Dergaa, Ismail AU - Dergaa I AD - High Institute of Sport, and Physical Education of Ksar Said, University of Manouba, Manouba, Tunisia. LA - eng PT - Journal Article DEP - 20251214 PL - England TA - Health Psychol Behav Med JT - Health psychology and behavioral medicine JID - 101624393 PMC - PMC12707080 OTO - NOTNLM OT - Adolescent health OT - body image perception OT - cross-cultural assessment OT - psychometric validation OT - psychosocial risk factors COIS- In preparing this paper, the authors used the ChatGPT model 4 on May 13, 2025, to revise specific passages of the manuscript, double-check for grammatical errors, and enhance academic English. After using this tool, the authors have reviewed and edited the content as necessary and take full responsibility for the publication's content. In preparing this paper, the authors used the ChatGPT model 4 on May 12, 2025, to revise specific passages of the manuscript, double-check for grammatical errors, and improve the academic English (Dergaa et al., 2024, Dergaa et al., 2023). After using this tool, the authors have reviewed and edited the content as necessary and take full responsibility for the publication's content. EDAT- 2025/12/18 07:19 MHDA- 2025/12/18 07:20 PMCR- 2025/12/14 CRDT- 2025/12/18 04:35 PHST- 2025/12/18 07:20 [medline] PHST- 2025/12/18 07:19 [pubmed] PHST- 2025/12/18 04:35 [entrez] PHST- 2025/12/14 00:00 [pmc-release] AID - 2601400 [pii] AID - 10.1080/21642850.2025.2601400 [doi] PST - epublish SO - Health Psychol Behav Med. 2025 Dec 14;13(1):2601400. doi: 10.1080/21642850.2025.2601400. eCollection 2025. PMID- 41409097 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251218 LR - 20251220 IS - 2279-9028 (Print) IS - 2279-9036 (Electronic) IS - 2279-9028 (Linking) VI - 14 IP - 4 DP - 2025 Oct TI - Enhancing awareness of risk factors for polycystic ovarian syndrome: The critical need for attention among adolescents and parents in coastal Karnataka, India. PG - 22799036251401944 LID - 10.1177/22799036251401944 [doi] LID - 22799036251401944 AB - BACKGROUND: Despite its high prevalence (6% and 26%), PCOS is undiagnosed and thus takes longer to identify. OBJECTIVE: To assess knowledge about the risk factors of polycystic ovary syndrome among healthcare professional students and to identify the association between demographic data and the knowledge scores concerning the risk factors for polycystic ovarian syndrome. DESIGN AND METHODS: A cross-sectional survey was conducted among 400 female healthcare professional students from Udupi Taluk, South India. The participants were recruited through a simple random technique. The baseline data and knowledge of risk factors for PCOS were measured using a validated and retested structured questionnaire. The data were analyzed using descriptive and inferential statistics using SPSS version 16. RESULTS: The mean age of the study participants was 20.31 +/- 1.37 years. The study demonstrated that 18.8% were overweight, 11.3% were suffering from PCOS, and 11.3% had a family history of PCOS. Approximately 75.5% of the participants had an average knowledge of PCOS, and 2.3% had poor knowledge. Sixty-six percent of the participants were not aware that dietary practices influence PCOS, various risk factors (66%), preventive measures (83.5%), risks associated with pregnancy due to PCOS (81.2%), measures to control the complications of PCOS (66.2%), complications of PCOS (57.5%), and the type of food used as a risk factor for PCOS (55%). CONCLUSIONS: Adolescents and young women are not very aware of various risk factors, complications, and measures to control the complications of PCOS. Periodic screening and successful awareness programs will facilitate improved understanding, increased diagnosis, and effective management of PCOS. CI - (c) The Author(s) 2025. FAU - Mascarenhas, Lisa Aslin AU - Mascarenhas LA AD - Manipal College of Nursing, Manipal Academy of Higher Education, Manipal, Karnataka, India. FAU - Mathew, Ananya Ann AU - Mathew AA AD - Manipal College of Nursing, Manipal Academy of Higher Education, Manipal, Karnataka, India. FAU - Saji, Anju AU - Saji A AD - Manipal College of Nursing, Manipal Academy of Higher Education, Manipal, Karnataka, India. FAU - Baby, Reenu AU - Baby R AD - Manipal College of Nursing, Manipal Academy of Higher Education, Manipal, Karnataka, India. FAU - Joseph, Jeslyn AU - Joseph J AD - Manipal College of Nursing, Manipal Academy of Higher Education, Manipal, Karnataka, India. FAU - Abraham, Aju Thomas AU - Abraham AT AD - Manipal College of Nursing, Manipal Academy of Higher Education, Manipal, Karnataka, India. FAU - Ansuya AU - Ansuya AUID- ORCID: 0000-0002-5667-5539 AD - Manipal College of Nursing, Manipal Academy of Higher Education, Manipal, Karnataka, India. FAU - Datta, Rakesh AU - Datta R AD - Manipal College of Nursing, Manipal Academy of Higher Education, Manipal, Karnataka, India. LA - eng PT - Journal Article DEP - 20251214 PL - United States TA - J Public Health Res JT - Journal of public health research JID - 101580775 PMC - PMC12705981 OTO - NOTNLM OT - adolescents and young women OT - female healthcare professionals OT - knowledge OT - polycystic ovarian syndrome OT - risk factors COIS- The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/12/18 07:20 MHDA- 2025/12/18 07:21 PMCR- 2025/12/14 CRDT- 2025/12/18 04:24 PHST- 2025/06/27 00:00 [received] PHST- 2025/11/12 00:00 [accepted] PHST- 2025/12/18 07:21 [medline] PHST- 2025/12/18 07:20 [pubmed] PHST- 2025/12/18 04:24 [entrez] PHST- 2025/12/14 00:00 [pmc-release] AID - 10.1177_22799036251401944 [pii] AID - 10.1177/22799036251401944 [doi] PST - epublish SO - J Public Health Res. 2025 Dec 14;14(4):22799036251401944. doi: 10.1177/22799036251401944. eCollection 2025 Oct. PMID- 41408578 OWN - NLM STAT- MEDLINE DCOM- 20251218 LR - 20251221 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 13 IP - 1 DP - 2025 Dec 17 TI - The Turkiye orthorexia nervosa scale (TONS-29): development and psychometric validation for adult populations. PG - 1364 LID - 10.1186/s40359-025-03634-8 [doi] LID - 1364 AB - INTRODUCTION: Orthorexia Nervosa (ON), first described by Steven Bratman in 1997, refers to a pathological obsession with healthy eating, often resulting in restrictive dietary behaviors, nutritional deficiencies, and impaired psychosocial functioning. In the absence of standardized diagnostic criteria, this study aimed to develop and validate the Turkiye Orthorexia Nervosa Scale (TONS-29). METHODS: After excluding individuals with a diagnosed eating disorder (n = 7) or without informed consent (n = 8), a total of 720 adults (489 women, 231 men) participated. Scale development was guided by expert opinions from professionals in nutrition, psychiatric nursing, and Turkish linguistics. Construct validity was assessed through Exploratory Factor Analysis (EFA; n = 360) and Confirmatory Factor Analysis (CFA; n = 360) on randomly divided samples. A test-retest analysis was conducted with 128 participants. RESULTS: The final scale includes 29 items across five subfactors, with a Cronbach's alpha of 0.941 and explained variance of 49.63%. Subdimension reliability was good to excellent (alpha = 0.724-0.908). CFA results indicated good model fit (chi-square/degrees of freedom [chi(2)/df] = 2.319, Root Mean Square Error of Approximation [RMSEA] = 0.061, Standardized Root Mean Square Residual [SRMR] = 0.052, Incremental Fit Index [IFI] = 0.907, Comparative Fit Index [CFI] = 0.906, Goodness of Fit Index [GFI] = 0.855, and Tucker-Lewis Index [TLI] = 0.907). The scale demonstrated temporal stability, with an intraclass correlation coefficient of 75.1% (95% CI: 0.647-0.824). CONCLUSION: The findings support the TONS-29 as a valid and reliable tool for assessing ON tendencies in Turkish adults. CI - (c) 2025. The Author(s). FAU - Kavsara, Hasan Kaan AU - Kavsara HK AUID- ORCID: 0000-0002-0322-0397 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Istanbul Medipol University, Istanbul, Turkiye. kaan.kavsara@yeditepe.edu.tr. AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Yeditepe University, Istanbul, Turkiye. kaan.kavsara@yeditepe.edu.tr. FAU - Kalkan, Indrani AU - Kalkan I AUID- ORCID: 0000-0001-6020-349X AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Istanbul Medipol University, Istanbul, Turkiye. indrani.kalkan@medipol.edu.tr. LA - eng PT - Journal Article PT - Validation Study DEP - 20251217 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Female MH - Male MH - Psychometrics MH - Adult MH - Reproducibility of Results MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Turkey MH - Young Adult MH - Middle Aged MH - Factor Analysis, Statistical MH - *Feeding Behavior/psychology MH - Surveys and Questionnaires MH - Adolescent PMC - PMC12709791 OTO - NOTNLM OT - Adult population OT - Disordered eating OT - Eating behaviors OT - Orthorexia nervosa OT - Psychometric validation OT - Scale development COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Yeditepe University Non-Interventional Clinical Research Institutional Review Board and Ethics Committee with the number "E.83321821-805.02.03-276" on 10/11/2023. The authors declare that the protocols of the Declaration of Helsinki were followed for all experiments involving human subjects and that all procedures were carried out with the informed and signed written consent of the participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/18 07:20 MHDA- 2025/12/18 07:21 PMCR- 2025/12/17 CRDT- 2025/12/18 00:09 PHST- 2025/07/22 00:00 [received] PHST- 2025/10/27 00:00 [accepted] PHST- 2025/12/18 07:21 [medline] PHST- 2025/12/18 07:20 [pubmed] PHST- 2025/12/18 00:09 [entrez] PHST- 2025/12/17 00:00 [pmc-release] AID - 10.1186/s40359-025-03634-8 [pii] AID - 3634 [pii] AID - 10.1186/s40359-025-03634-8 [doi] PST - epublish SO - BMC Psychol. 2025 Dec 17;13(1):1364. doi: 10.1186/s40359-025-03634-8. PMID- 41407932 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260120 LR - 20260124 IS - 2730-664X (Electronic) IS - 2730-664X (Linking) VI - 6 IP - 1 DP - 2025 Dec 17 TI - A metabolomic signature of maternal BMI is associated with pregnancy complications across two independent pregnancy cohorts. PG - 38 LID - 10.1038/s43856-025-01289-5 [doi] LID - 38 AB - BACKGROUND: Maternal obesity is increasingly common and linked to pregnancy complications, likely driven by underlying metabolic perturbations. This study investigates the association between maternal pre-pregnancy body mass index (BMI) and pregnancy complications through blood metabolomics, aiming to identify specific metabolites mediating these associations. METHODS: Data from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) and Vitamin D Antenatal Asthma Reduction Trial (VDAART) cohorts were used, with untargeted blood metabolomics performed on blood samples taken during early-, mid-, and late gestation. Associations were assessed using multivariable logistic regression and mediation analyses to explore metabolite pathways linking maternal BMI with pregnancy complications. RESULTS: In the COPSAC2010 cohort, maternal pre-pregnancy BMI is associated with gestational diabetes (OR 1.90 [1.29-2.74], p = 6.75x10(-)(4)), caesarean section (OR 1.23 [1.03-1.47], p = 0.023), and birth induction (OR 1.42 [1.21-1.67], p = 2.86x10(-)(5)). A BMI-associated metabolite score is even more strongly associated with these complications and is independently associated with preeclampsia (OR 1.54 [1.04-2.26], p = 0.030). Validation in the VDAART cohort confirms the predictive value of the metabolite score for gestational diabetes (OR 2.10 [1.48-3.03], p = 4.97x10(-)(5)) and preeclampsia (OR 2.12 [1.32-3.47], p = 0.002), particularly in late gestation. Mediation analysis in COPSAC2010 identifies 16 metabolites as mediating the effect of BMI on gestational diabetes. A model based on this subset of metabolites significantly outperforms the full maternal BMI model in predicting outcomes during both early (p = 0.009) and late gestation (p = 0.016) in the VDAART cohort. CONCLUSIONS: These findings suggest that integrating metabolomic profiling into prenatal care could improve the prediction and management of adverse pregnancy outcomes. CI - (c) 2025. The Author(s). FAU - Horner, David AU - Horner D AUID- ORCID: 0000-0002-0200-4561 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. david.horner@dbac.dk. FAU - Vinding, Rebecca AU - Vinding R AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. FAU - Wang, Tingting AU - Wang T AUID- ORCID: 0000-0002-9100-3447 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. FAU - Ali, Mina AU - Ali M AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. FAU - Lovric, Mario AU - Lovric M AUID- ORCID: 0000-0002-3541-9624 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. FAU - Prince, Nicole AU - Prince N AUID- ORCID: 0000-0002-8506-1122 AD - Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Lasky-Su, Jessica AU - Lasky-Su J AD - Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Bonnelykke, Klaus AU - Bonnelykke K AUID- ORCID: 0000-0003-2003-1018 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. FAU - Stokholm, Jakob AU - Stokholm J AUID- ORCID: 0000-0003-4989-9769 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. AD - Section of Food Microbiology, Gut Health and Fermentation, Department of Food Science, University of Copenhagen, Copenhagen, Denmark. FAU - Chawes, Bo AU - Chawes B AUID- ORCID: 0000-0001-6846-6243 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. FAU - Rasmussen, Morten Arendt AU - Rasmussen MA AUID- ORCID: 0000-0001-7431-5206 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. AD - Section of Food Microbiology, Gut Health and Fermentation, Department of Food Science, University of Copenhagen, Copenhagen, Denmark. LA - eng GR - K01 HL153941/HL/NHLBI NIH HHS/United States GR - R01 HL155742/HL/NHLBI NIH HHS/United States GR - R01 HL141826/HL/NHLBI NIH HHS/United States GR - 946228/EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)/ GR - R269-2017-5/Lundbeckfonden (Lundbeck Foundation)/ GR - 0603-00280B/Strategiske Forskningsrad (Danish Council for Strategic Research)/ GR - R01HL123915, R01HL155742, R01HL141826 and K01HL153941;amp;#x200B;;amp;#x200B;/Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.)/ GR - R01 HL123915/HL/NHLBI NIH HHS/United States GR - NNF21OC0068517/Novo Nordisk Fonden (Novo Nordisk Foundation)/ GR - R16-A1694/Lundbeckfonden (Lundbeck Foundation)/ PT - Journal Article DEP - 20251217 PL - England TA - Commun Med (Lond) JT - Communications medicine JID - 9918250414506676 PMC - PMC12820178 OAB - Many women enter pregnancy with a higher body weight, which increases the risk of complications such as diabetes, preeclampsia, and delivery by caesarean section. We wanted to understand why these risks occur and whether changes in the body's metabolism could explain them. To investigate this, we studied blood samples from two large groups of pregnant women in Denmark and the United States. We measured hundreds of small molecules, known as metabolites, and looked at how they relate to body weight and pregnancy outcomes. We found that certain metabolites help explain the link between higher body weight and complications such as diabetes and preeclampsia. These results suggest that blood metabolite testing could one day improve pregnancy care by identifying women at higher risk early on. OABL- eng COIS- Competing interests: J.L.-S. is a scientific advisor for Precion Inc and a consultant to Tru Diagnostic, Inc. Remaining authors (D.H., R.V., T.W., M.A., M.L., N.P., J.L.S., K.B., J.S., B.C., and M.R.) declare no potential, perceived, or real conflict of interest regarding the content of this manuscript. The funding agencies did not have any role in the design and conduct of the study; collection, management, and interpretation of the data; or preparation, review, or approval of the manuscript. No pharmaceutical company was involved in the study. EDAT- 2025/12/18 01:31 MHDA- 2025/12/18 01:32 PMCR- 2025/12/17 CRDT- 2025/12/17 23:28 PHST- 2024/10/18 00:00 [received] PHST- 2025/11/27 00:00 [accepted] PHST- 2025/12/18 01:32 [medline] PHST- 2025/12/18 01:31 [pubmed] PHST- 2025/12/17 23:28 [entrez] PHST- 2025/12/17 00:00 [pmc-release] AID - 10.1038/s43856-025-01289-5 [pii] AID - 1289 [pii] AID - 10.1038/s43856-025-01289-5 [doi] PST - epublish SO - Commun Med (Lond). 2025 Dec 17;6(1):38. doi: 10.1038/s43856-025-01289-5. PMID- 41407847 OWN - NLM STAT- MEDLINE DCOM- 20260121 LR - 20260124 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2025 Dec 17 TI - ME-BYO index as a formative construct for healthy ageing: a cross-sectional PLS-SEM analysis. PG - 2766 LID - 10.1038/s41598-025-32665-9 [doi] LID - 2766 AB - Innovative health measures are essential for promoting "healthy aging." The "ME-BYO" index considers health to exist on a continuum scale rather than as a binary state. This investigation sought to validate the ME-BYO index as a formative construct, examining if its constituent domains appropriately reflect overall health status using empirical data from the Kanagawa Prospective "ME-BYO" Cohort Study. We analyzed cross-sectional baseline data from 4,218 participants (aged 18-95 years, mean age, 57.8; 55.5% female) in the ME-BYO cohort. The ME-BYO index was specified as a higher-order formative construct composed of body mass index; blood pressure construct (systolic blood pressure, hypertension history); the 5-item Geriatric Locomotive Function Scale (GLFS-5) for locomotor function; and the 6-item Kessler Psychological Distress Scale (K6) for mental health. Its association with subjective well-being, a composite outcome including quality of life and subjective happiness, was examined using structural equation modeling. The GLFS-5 (outer weight: 0.695, t = 35.47) and the K6 (0.617, t = 20.23) were the strongest indicators of the ME-BYO index. Higher scores on the ME-BYO index (showing worse health) had a strong negative relationship with the subjective well-being outcome (path coefficient: -0.676, t = 71.99), accounting for 45.7% of the variance (R(2)). The ME-BYO index is a structurally valid formative measure that combines indicators from locomotor, mental, and metabolic domains. Its significant capacity to reflect subjective well-being supports its practical application in health surveillance and as a tool for empowering individuals to manage their health proactively. CI - (c) 2025. The Author(s). FAU - Nakamura, Sho AU - Nakamura S AD - Graduate School of Health Innovation, Kanagawa University of Human Services, Kawasaki, Kanagawa, Japan. research@nakasho.org. AD - Center for Innovation Policy, Kanagawa University of Human Services, Kawasaki, Kanagawa, Japan. research@nakasho.org. AD - Cancer Prevention and Control Division, Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa, Japan. research@nakasho.org. AD - Department of Genetic Medicine, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan. research@nakasho.org. FAU - Watanabe, Kaname AU - Watanabe K AD - Center for Innovation Policy, Kanagawa University of Human Services, Kawasaki, Kanagawa, Japan. AD - Cancer Prevention and Control Division, Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa, Japan. AD - Department of Genetic Medicine, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan. FAU - Chei, Choy-Lye AU - Chei CL AD - Cancer Prevention and Control Division, Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa, Japan. AD - Department of Genetic Medicine, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan. FAU - Feng, Lei AU - Feng L AD - Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. AD - Centre for Healthy Longevity, National University Health System, Singapore, Singapore. AD - Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. FAU - Ye, Kaisy Xinhong AU - Ye KX AD - Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. AD - Centre for Healthy Longevity, National University Health System, Singapore, Singapore. AD - Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. FAU - Lim, Kai Xuan AU - Lim KX AD - Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. AD - Centre for Healthy Longevity, National University Health System, Singapore, Singapore. AD - Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. FAU - Watanabe, Ryo AU - Watanabe R AD - Graduate School of Health Innovation, Kanagawa University of Human Services, Kawasaki, Kanagawa, Japan. AD - Center for Innovation Policy, Kanagawa University of Human Services, Kawasaki, Kanagawa, Japan. FAU - Chung, Ung-Il AU - Chung UI AD - Graduate School of Health Innovation, Kanagawa University of Human Services, Kawasaki, Kanagawa, Japan. AD - Center for Innovation Policy, Kanagawa University of Human Services, Kawasaki, Kanagawa, Japan. AD - Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan. FAU - Narimatsu, Hiroto AU - Narimatsu H AD - Graduate School of Health Innovation, Kanagawa University of Human Services, Kawasaki, Kanagawa, Japan. AD - Center for Innovation Policy, Kanagawa University of Human Services, Kawasaki, Kanagawa, Japan. AD - Cancer Prevention and Control Division, Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa, Japan. AD - Department of Genetic Medicine, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan. LA - eng GR - 16H06277/Japan Society for the Promotion of Science/ GR - 22H04923/Japan Society for the Promotion of Science/ GR - 17015018/Japanese Ministry of Education, Culture, Sports, Science and Technology/ GR - 221S0001/Japanese Ministry of Education, Culture, Sports, Science and Technology/ PT - Journal Article DEP - 20251217 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Aged MH - Middle Aged MH - Cross-Sectional Studies MH - Male MH - Adult MH - Aged, 80 and over MH - *Healthy Aging/physiology/psychology MH - Adolescent MH - Quality of Life MH - Young Adult MH - Health Status MH - Mental Health MH - Body Mass Index MH - Blood Pressure MH - Prospective Studies PMC - PMC12824396 OTO - NOTNLM OT - Cross-sectional studies OT - Healthy aging OT - Locomotion OT - Longevity OT - ME-BYO OT - Mental health OT - Quality of life OT - Structural equation modeling COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval and consent to participate: The ME-BYO cohort and analyses performed in this study were approved by the Ethics Committee of Kanagawa Cancer Center (Yokohama, Japan; approval no. 28KEN-36), and written informed consent was obtained from all participants. EDAT- 2025/12/18 01:31 MHDA- 2026/01/22 01:09 PMCR- 2025/12/17 CRDT- 2025/12/17 23:25 PHST- 2025/09/30 00:00 [received] PHST- 2025/12/11 00:00 [accepted] PHST- 2026/01/22 01:09 [medline] PHST- 2025/12/18 01:31 [pubmed] PHST- 2025/12/17 23:25 [entrez] PHST- 2025/12/17 00:00 [pmc-release] AID - 10.1038/s41598-025-32665-9 [pii] AID - 32665 [pii] AID - 10.1038/s41598-025-32665-9 [doi] PST - epublish SO - Sci Rep. 2025 Dec 17;16(1):2766. doi: 10.1038/s41598-025-32665-9. PMID- 41406002 OWN - NLM STAT- MEDLINE DCOM- 20251217 LR - 20260925 IS - 1536-7290 (Electronic) IS - 1746-1391 (Print) IS - 1536-7290 (Linking) VI - 26 IP - 1 DP - 2026 Jan TI - Validation of the Modified Athlete Dietary Index (mADI) Against a 7-Day Food Record Assessing Food Consumption Among Irish Athletes. PG - e70110 LID - 10.1002/ejsc.70110 [doi] LID - e70110 AB - Nutrition is crucial for enhancing performance and overall health among athletes. However, detailed dietary assessments are often time-consuming, challenging to conduct accurately, and burdensome. Therefore, there is a need for a more time and cost-effective method for assessing dietary intake among Irish athletes. This study aimed to validate a modified Athlete Dietary Index (mADI) as a screening tool for use among Irish athletes. Eligible participants included team and individual sport athletes over the age of 18 years, currently competing in competitions. Participants completed the electronic mADI followed by a 7-day food record (7DFR) using Qualtrics and Nutritics software platforms. Misreporting was assessed using the Goldberg cut-off. Validity for each food group was evaluated based on weighted kappa, two-way mixed effects intraclass correlation coefficient (ICC), relative bias, and Bland-Altman graphs. Eighty athletes (28.74 +/- 9.77 years) completed the mADI and 7DFR. Poor validity was found for servings per day (% bias > 20%, ICC < 0.50). Only eggs showed good validity for servings per week (-1.7% bias, ICC = 0.55). Acceptable to good validity (% bias < 10.9%) was observed for days per week, with 54% of food groups demonstrating good validity. Weighted kappa indicated an acceptable level of agreement for 62% of the comparisons. Overall, ICC suggested poor reliability for all but three food groups (eggs 0.55; fish 0.52; plant-based protein 0.63). The mADI demonstrated limited validity in assessing diet quality among athletes but showed potential as a screening tool to evaluate habitual dietary intake patterns in large groups of Irish athletes. CI - (c) 2025 The Author(s). European Journal of Sport Science published by Wiley-VCH GmbH on behalf of European College of Sport Science. FAU - Cremona, Alexandra AU - Cremona A AUID- ORCID: 0000-0002-4996-1430 AD - Faculty of Education and Health Sciences, School of Allied Health, University of Limerick, Limerick, Ireland. AD - Irish Nutrition and Dietetics Institute, Dublin, Ireland. AD - Health Research Institute, University of Limerick, Limerick, Ireland. FAU - Heidarian, Hamid Miri AU - Heidarian HM AD - School of Food and Nutritional Sciences, University College Cork, Cork, Ireland. FAU - Spillane, Keela AU - Spillane K AD - Faculty of Education and Health Sciences, School of Allied Health, University of Limerick, Limerick, Ireland. AD - Irish Nutrition and Dietetics Institute, Dublin, Ireland. FAU - Coady, Brian AU - Coady B AD - Faculty of Education and Health Sciences, School of Allied Health, University of Limerick, Limerick, Ireland. AD - Irish Nutrition and Dietetics Institute, Dublin, Ireland. FAU - Capling, Louise AU - Capling L AD - Faculty of Medicine and Health, Sydney School of Health Sciences, The University of Sydney, Camperdown, Australia. LA - eng PT - Journal Article PT - Validation Study PL - Germany TA - Eur J Sport Sci JT - European journal of sport science JID - 101146739 SB - IM MH - Humans MH - *Diet Records MH - Ireland MH - Male MH - *Athletes MH - Adult MH - Female MH - Young Adult MH - *Diet MH - Reproducibility of Results MH - *Nutrition Assessment MH - Adolescent PMC - PMC12710794 OTO - NOTNLM OT - athlete nutrition OT - dietary assessment OT - food record composition OT - irish athletes OT - mADI validation COIS- The authors declare no conflicts of interest. EDAT- 2025/12/17 19:11 MHDA- 2025/12/17 19:12 PMCR- 2025/12/17 CRDT- 2025/12/17 12:42 PHST- 2025/08/28 00:00 [revised] PHST- 2024/09/03 00:00 [received] PHST- 2025/12/06 00:00 [accepted] PHST- 2025/12/17 19:12 [medline] PHST- 2025/12/17 19:11 [pubmed] PHST- 2025/12/17 12:42 [entrez] PHST- 2025/12/17 00:00 [pmc-release] AID - EJSC70110 [pii] AID - 10.1002/ejsc.70110 [doi] PST - ppublish SO - Eur J Sport Sci. 2026 Jan;26(1):e70110. doi: 10.1002/ejsc.70110. PMID- 41403482 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251217 LR - 20251219 IS - 2249-4863 (Print) IS - 2278-7135 (Electronic) IS - 2249-4863 (Linking) VI - 14 IP - 11 DP - 2025 Nov TI - Nutritional status of under-5 children in Bangalore city during the COVID-19 pandemic. PG - 4763-4769 LID - 10.4103/jfmpc.jfmpc_497_25 [doi] AB - BACKGROUND: COVID-19 pandemic and the resultant social isolation, declined vaccination, and lack of school enrolment have contributed to undernutrition among children. OBJECTIVES: To assess nutritional status and associated factors among children aged 1-5 years enrolled in urban Anganwadis in Austin Town area, Bangalore city, during the COVID-19 pandemic. METHODOLOGY: A random sample of 100 children aged 1-5 years enrolled in two Anganwadis located in Austin Town was chosen. Data were collected using a structured face-validated questionnaire and measuring anthropometry. Nutrition status was classified using WHO Child Growth Standards. RESULT: There were 43% females and 57% males. The majority were in the age group of 4-5 years (32%) and belonged to a nuclear family 47%. 76% had a birth weight of more than 2.5 kg, 80% of them were full term, and 92% were immunized for age. Pre-COVID-19, 26% of the families were in lower middle and lower classes, and this proportion increased to 46% during COVID-19. Moderate acute malnutrition was observed among 12% of the children, and severe acute malnutrition was observed among 4% of the children. The factor which was significantly associated with malnutrition was the child's diet history of 3 meals and 2 snacks per day (P value 0.02). CONCLUSION: The prevalence of severe acute malnutrition is 4%. Child's diet history of 3 meals and 2 snacks is a significant protective factor against malnutrition. Community-based intervention such as nutrition education should be provided at Anganwadis for prevention of childhood malnutrition. CI - Copyright: (c) 2025 Journal of Family Medicine and Primary Care. FAU - Miranda, Neha Harshita AU - Miranda NH AD - Department of Community Health, St. John's Medical College, Bengaluru, Karnataka, India. FAU - Fare, Nadeen AU - Fare N AD - Department of Community Health, St. John's Medical College, Bengaluru, Karnataka, India. FAU - Gnanaselvam, Nancy Angeline AU - Gnanaselvam NA AD - Department of Community Health, St. John's Medical College, Bengaluru, Karnataka, India. FAU - Johnson, Avita Rose AU - Johnson AR AD - Department of Community Health, St. John's Medical College, Bengaluru, Karnataka, India. FAU - Ramesh, Naveen AU - Ramesh N AD - Department of Community Health, St. John's Medical College, Bengaluru, Karnataka, India. FAU - Shetty, Anupama AU - Shetty A AD - Director, Biocon Foundation, Bengaluru, Karnataka, India. LA - eng PT - Journal Article DEP - 20251129 PL - India TA - J Family Med Prim Care JT - Journal of family medicine and primary care JID - 101610082 PMC - PMC12704956 OTO - NOTNLM OT - COVID-19 OT - Children OT - WHO growth charts OT - growth monitoring OT - malnutrition OT - moderate acute malnutrition OT - nutrition OT - severe acute malnutrition OT - stunting OT - wasting COIS- There are no conflicts of interest. EDAT- 2025/12/17 06:40 MHDA- 2025/12/17 06:41 PMCR- 2025/11/01 CRDT- 2025/12/17 04:34 PHST- 2025/03/24 00:00 [received] PHST- 2025/06/20 00:00 [revised] PHST- 2025/06/23 00:00 [accepted] PHST- 2025/12/17 06:41 [medline] PHST- 2025/12/17 06:40 [pubmed] PHST- 2025/12/17 04:34 [entrez] PHST- 2025/11/01 00:00 [pmc-release] AID - JFMPC-14-4763 [pii] AID - 10.4103/jfmpc.jfmpc_497_25 [doi] PST - ppublish SO - J Family Med Prim Care. 2025 Nov;14(11):4763-4769. doi: 10.4103/jfmpc.jfmpc_497_25. Epub 2025 Nov 29. PMID- 41402942 OWN - NLM STAT- MEDLINE DCOM- 20260121 LR - 20260123 IS - 1745-6215 (Electronic) IS - 1745-6215 (Linking) VI - 27 IP - 1 DP - 2025 Dec 16 TI - Design and implementation of a theory of planned behavior-based nutrition education intervention for adolescent girls in rural Nepal: a school-based cluster-randomized controlled trial. PG - 55 LID - 10.1186/s13063-025-09375-8 [doi] LID - 55 AB - Adolescence is a pivotal period of physical, psychological, and cognitive development during which individuals are highly vulnerable to nutritional deficiency. Undernutrition, overweight/obesity, and anemia are prominent public health concerns in low- and middle-income countries, including Nepal. Anemia affects nearly one-quarter of individuals aged 10-24 years globally, with a disproportionately high burden in resource-constrained settings. This study primarily aims to evaluate the effectiveness of a theory-driven school-based nutrition education intervention in improving dietary behaviors, health literacy, and nutritional status among adolescent girls in rural Nepal. This two-arm randomized controlled trial (RCT) evaluated the effectiveness of the Nutrition Education Intervention for Promoting Health (NEIPH) program for improving the nutritional status of adolescent girls in rural Nepal. Adolescent girls (200) with low serum ferritin levels (40.7-75.7 ng/mL), enrolled in grades 7-9 across 19 public schools in Annapurna Rural Municipality, were randomly assigned to either an intervention (103 girls from nine schools) or a control (97 girls from 10 schools) group. The intervention group received two 60-min interactive education sessions over 1 month, school-based monitoring, and a standardized educational booklet. The sessions incorporated multimedia presentations, role-play activities, group discussions, and teach-back exercises to reinforce key concepts. The control group received booklets approved by the National Health Education, Information, and Communication Center. The educational content covered balanced nutrition, dietary sources, anemia prevention, adolescent health, and menstrual hygiene and was delivered using multimedia tools and participatory techniques. The NEIPH intervention is expected to be a viable approach for improving the nutritional status and reducing anemia by influencing the behaviors of adolescent girls. The combined use of the theory of planned behavior and the teach-back method represents a novel and structured approach to enhance comprehension, promote self-efficacy, and foster sustained behavioral change. The trial is currently ongoing, and no outcome data have been analyzed. This paper provides a detailed account of the theoretical framework, intervention development, and implementation procedures to promote methodological transparency and reproducibility. CI - (c) 2025. The Author(s). FAU - Bhandari, Tulsi Ram AU - Bhandari TR AD - Faculty of Health Science, School of Health and Allied Sciences, Pokhara University, Lekhnath, Nepal. FAU - Paudel, Shishir AU - Paudel S AUID- ORCID: 0000-0003-3077-6697 AD - Kathmandu Institute of Child Health, Hepali Height, Budhanilkantha, Kathmandu, Nepal. shishirpaudel11@gmail.com. FAU - Chapagain, Nawaraj AU - Chapagain N AD - Nutrition Research Project of Kansai Medical University, Japan, in Annapurna Rural Municipality, Kaski, Nepal. FAU - Thapa, Yoko Oda AU - Thapa YO AD - Nutrition Research Project of Kansai Medical University, Japan, in Annapurna Rural Municipality, Kaski, Nepal. FAU - Nagila, Amar AU - Nagila A AD - Faculty of Health Science, School of Health and Allied Sciences, Pokhara University, Lekhnath, Nepal. FAU - Kawata, Rina AU - Kawata R AD - Department of Nursing, Faculty of Human Care at Makuhari, Tohto University, Chiba, Japan. FAU - Iwakuni, Akiko AU - Iwakuni A AD - Faculty of Nursing, Kansai Medical University, Hirakata, Japan. FAU - Lee, Kumsun AU - Lee K AD - Faculty of Nursing, Graduate School of Nursing, Kansai Medical University, Hirakata, Japan. FAU - Hiroko, Sakai AU - Hiroko S AD - Faculty of Nursing, Graduate School of Nursing, Kansai Medical University, Hirakata, Japan. LA - eng GR - 22KK0026/Japan Society of the Promotion of Science (JSPS)/ PT - Clinical Trial Protocol PT - Journal Article DEP - 20251216 PL - England TA - Trials JT - Trials JID - 101263253 SB - IM MH - Humans MH - Adolescent MH - Female MH - Nepal MH - Nutritional Status MH - *Health Education/methods MH - Child MH - *Adolescent Behavior MH - Health Knowledge, Attitudes, Practice MH - *School Health Services MH - Health Literacy MH - *Diet, Healthy MH - *Health Behavior MH - Rural Population MH - *Adolescent Nutritional Physiological Phenomena MH - Young Adult MH - Randomized Controlled Trials as Topic MH - *Feeding Behavior MH - Theory of Planned Behavior PMC - PMC12821813 OTO - NOTNLM OT - Adolescents OT - Anemia OT - Intervention OT - Malnutrition OT - Preconception care OT - Randomized controlled trial OT - Theory of planned behavior COIS- Ethics approval and consent to participate: The research protocol was reviewed and approved by the Nepal Health Research Council (Proposal ID 704-2023, approved review date: January 23, 2024). Consent for publication: NA Competing interests: The authors declare that they have no competing interests. EDAT- 2025/12/17 00:25 MHDA- 2026/01/21 06:30 PMCR- 2025/12/16 CRDT- 2025/12/16 23:46 PHST- 2025/08/11 00:00 [received] PHST- 2025/12/05 00:00 [accepted] PHST- 2026/01/21 06:30 [medline] PHST- 2025/12/17 00:25 [pubmed] PHST- 2025/12/16 23:46 [entrez] PHST- 2025/12/16 00:00 [pmc-release] AID - 10.1186/s13063-025-09375-8 [pii] AID - 9375 [pii] AID - 10.1186/s13063-025-09375-8 [doi] PST - epublish SO - Trials. 2025 Dec 16;27(1):55. doi: 10.1186/s13063-025-09375-8. PMID- 41402912 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1824-7288 (Electronic) IS - 1720-8424 (Linking) VI - 52 IP - 1 DP - 2025 Dec 16 TI - The impact of nutritional and socioeconomic status on academic performance of primary urban school children in northern Ethiopia: a cross-sectional study. PG - 10 LID - 10.1186/s13052-025-02175-5 [doi] LID - 10 AB - BACKGROUND: Urban school children are challenged from varying degrees of poverty, access to resources and health services ultimately impacting their academic performance. Educational success is complex highlighting that several factors may contribute to its outcome. Among these, undernutrition and socioeconomic status significantly impact academic performance. The interplay between these determinants and educational outcomes is particularly significant in developing countries such as northern Ethiopia. Children from lower socioeconomic backgrounds often experience nutritional deficiencies that can adversely impact cognitive development leading for poor educational achievement. Thus, this research can fill existing gaps regarding the interaction between undernutrition and socioeconomic factors that enable to understand how they interact to affect children's educational outcomes. In addition, the study will provide practical implications for policymakers and educators in Ethiopia as it enables them for developing more effective educational policies that address unique challenges faced by urban school children in northern Ethiopia. Therefore, our study aimed to assess predictors of academic performance among primary school students to address the multifaceted issues and develop effective interventions. METHOD: This institution-based cross-sectional study was conducted in three of seven primary public schools. Simple random sampling technique were employed to select the schools and proportional allocation was done to each school to draw a total of 399 study participants. An interviewer administered questionnaire were used to gather socioeconomic data from the children's legal guardians. Academic performance was evaluated using the average scores from all subjects over two semesters obtained from school rosters. Nutritional status was assessed via anthropometric measurements with Height-for-Age (HAZ), Weight-for- Age (WAZ) and Body Mass Index-for-Age (BAZ) calculated according to the WHO 2007 standard reference guidelines. WHO Anthro version 3.2.2 was used for the analysis and interpretation of nutritional status. Data were entered, cleaned and validated using Epi Data version 3.1 and subsequently analyzed using SPSS version 24. A bivariate and multivariate logistic regression were done to determine candidate variables and significantly associated factors respectively. Variables with p-value of 15 years were recruited from the Nutrition and Health Survey data. Dietary patterns were discerned through principal component analysis (PCA) and reduced rank regression (RRR). Associations between dietary pattern scores, vitamin D, and anemia-related biomarkers were validated using linear and binomial logistic regression adjusted for sociodemographic and economic factors. Results: Two dietary patterns were identified: a plant and marine-based dietary pattern (PMDP) via PCA and a convenience food dietary pattern (CFDP) via RRR. PMDP was characterized by high intakes of plant and marine foods, while CFDP showed high intakes of canned and pickled foods. Risk estimation indicated that high PMDP intake was associated with 30% reduction in odds of vitamin D insufficiency, while moderate CFDP intake was linked to an increased risk of vitamin D insufficiency by 46%. Logistic regression analysis showed a positive association between CFDP and serum iron (beta = 0.08; 95% CI: 0.05, 0.24), but a negative association with total iron binding capacity (beta = -0.05; 95% CI: -0.44, -0.07). Conclusions: The PCA-derived dietary pattern effectively identifies eating patterns, while the RRR-derived dietary pattern has a better estimate for disease associations in a specific population. The RRR-derived dietary pattern provides valuable insights for dietary guidelines targeting vitamin D insufficiency. CI - (c) The author(s). FAU - Das, Arpita AU - Das A AD - School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan. FAU - Hsu, Chien-Yeh AU - Hsu CY AD - Department of Information Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan. AD - Master Program in Global Health and Health Security, Taipei Medical University, Taipei, Taiwan. FAU - Bai, Chyi-Huey AU - Bai CH AD - Department of Public Health, School of Medicine, Taipei Medical University, Taipei, Taiwan. AD - School of Public Health, Taipei Medical University, Taipei, Taiwan. AD - Nutrition Research Center, Taipei Medical University Hospital, Taipei, Taiwan. FAU - Chang, Jung-Su AU - Chang JS AD - School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan. AD - Nutrition Research Center, Taipei Medical University Hospital, Taipei, Taiwan. AD - Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, Taiwan. AD - TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, Taiwan. FAU - Huang, Ya-Li AU - Huang YL AD - Department of Public Health, School of Medicine, Taipei Medical University, Taipei, Taiwan. AD - School of Public Health, Taipei Medical University, Taipei, Taiwan. FAU - Wang, Fan-Fen AU - Wang FF AD - Department of Internal Medicine, Yangming Branch, Taipei City Hospital, Taipei, Taiwan. FAU - Nguyen, Nhi Thi Hong AU - Nguyen NTH AD - School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan. AD - Health Personnel Training Institute, University of Medicine and Pharmacy, Hue University, Hue, Vietnam. FAU - Chen, Yi-Chun AU - Chen YC AD - School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan. FAU - Chao, Jane C-J AU - Chao JC AD - School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan. AD - Master Program in Global Health and Health Security, Taipei Medical University, Taipei, Taiwan. AD - Nutrition Research Center, Taipei Medical University Hospital, Taipei, Taiwan. AD - TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, Taiwan. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260101 PL - Australia TA - Int J Med Sci JT - International journal of medical sciences JID - 101213954 RN - 1406-16-2 (Vitamin D) SB - IM MH - Humans MH - Female MH - *Vitamin D Deficiency/epidemiology/blood/etiology MH - Adult MH - Cross-Sectional Studies MH - Pregnancy MH - Vitamin D/blood MH - *Diet/adverse effects MH - Nutrition Surveys MH - Young Adult MH - Principal Component Analysis MH - *Feeding Behavior MH - *Anemia/epidemiology/blood/etiology MH - Adolescent PMC - PMC12702124 OTO - NOTNLM OT - anemia-related biomarkers OT - principal component analysis OT - reduced rank regression analysis OT - serum vitamin D COIS- Competing Interests: The authors have declared that no competing interest exists. EDAT- 2025/12/16 06:29 MHDA- 2025/12/16 06:30 PMCR- 2026/01/01 CRDT- 2025/12/16 04:03 PHST- 2025/08/20 00:00 [received] PHST- 2025/11/21 00:00 [accepted] PHST- 2025/12/16 06:30 [medline] PHST- 2025/12/16 06:29 [pubmed] PHST- 2025/12/16 04:03 [entrez] PHST- 2026/01/01 00:00 [pmc-release] AID - ijmsv23p0325 [pii] AID - 10.7150/ijms.124006 [doi] PST - epublish SO - Int J Med Sci. 2026 Jan 1;23(1):325-333. doi: 10.7150/ijms.124006. eCollection 2026. PMID- 41398899 OWN - NLM STAT- MEDLINE DCOM- 20260307 LR - 20261004 IS - 1522-726X (Electronic) IS - 1522-1946 (Linking) VI - 107 IP - 4 DP - 2026 Mar TI - SYNTAX Score as a Predictor of Angiographic Complexity in Stable Angina and Acute Coronary Syndrome Patients. PG - 949-954 LID - 10.1002/ccd.70420 [doi] AB - BACKGROUND: Coronary angiography is the gold standard for assessing coronary artery disease (CAD), while the SYNTAX score (SxS) quantifies lesion complexity. Its prognostic value across clinical settings remains uncertain. This study compared angiographic findings in stable angina and acute coronary syndrome (ACS) using the SxS. METHODS: A prospective study was conducted at Shaikh Zayed Hospital, Lahore, over 12 months, including 156 patients undergoing coronary angiography: stable angina (n = 78) and ACS (n = 78). Patients aged 18-80 years undergoing primary PCI or elective angiography were included, excluding prior PCI or CABG. Demographic and clinical data were collected, and SxS was applied post-angiography. Data were analyzed using SPSS v.25, with p 0.05). However, dyslipidemia was more prevalent in ACS patients (p < 0.05), and the mean SxS was significantly higher in ACS versus stable angina (28.2 +/- 9.9 vs. 23.8 +/- 12.4; p = 0.01), indicating greater angiographic complexity. DISCUSSION: The higher SxS in ACS patients indicated greater angiographic complexity, consistent with prior studies. Scores were also significantly elevated in patients with diabetes and hypertension, supporting the score's prognostic value in CAD stratification. However, the absence of clinical variables limits risk prediction. The single-center design, small sample size, lack of adjusted analyses, and absence of long-term outcomes further constrain generalizability, warranting validation in larger multicenter cohorts. CONCLUSION: The SxS was significantly higher in ACS than stable angina, supporting its role in guiding management, particularly in patients with comorbidities. Larger multicenter studies are needed to validate its prognostic utility. CI - (c) 2025 Wiley Periodicals LLC. FAU - Ashraf, Sohaib AU - Ashraf S AUID- ORCID: 0000-0003-3127-3557 AD - Department of Cardiology, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan. AD - Rehmatul Lil Alameen post graduate Institute of cardiology PESSI Multan Road, Lahore, Pakistan. FAU - Mujtaba, Amjad AU - Mujtaba A AD - Department of Cardiology, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan. FAU - Akmal, Rutaba AU - Akmal R AD - Department of Pharmacology, King Edward Medical University, Lahore, Pakistan. FAU - Shahab, Muhammad Sarmad AU - Shahab MS AD - Department of Pharmacology, King Edward Medical University, Lahore, Pakistan. FAU - Ahmad, Waseem AU - Ahmad W AD - Department of Internal Medicine, King Edward Medical University, Lahore, Pakistan. FAU - Shahbaz, Amir AU - Shahbaz A AD - Pakistan kidney and liver institute and research center, Lahore, Pakistan. FAU - Imran, Muhammad Ahmad AU - Imran MA AD - Cancer Centre, Howard University Hospital, Washington, USA. FAU - Khalid, Meer Hassan AU - Khalid MH AD - Department of Medicine, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan. FAU - Ashraf, Sidra AU - Ashraf S AUID- ORCID: 0000-0002-4254-2583 AD - University of Veterinary and Animal Sciences, Lahore, Pakistan. FAU - Akram, Muhammad Kiwan AU - Akram MK AD - University of Veterinary and Animal Sciences, Lahore, Pakistan. FAU - Bin Naeem, Usama AU - Bin Naeem U AD - Department of Pharmacology, Riphah International University, Islamabad, Pakistan. FAU - Kalsoom, Larab AU - Kalsoom L AD - Department of Medicine, Services Hospital, Lahore, Pakistan. FAU - Farooq, Usama AU - Farooq U AD - Department of Cardiology, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan. FAU - Javed, Zonera AU - Javed Z AD - Department of Cardiology, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan. FAU - Saleem, Muhammad Sikandar AU - Saleem MS AD - Department of Cardiology, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan. FAU - Pari, Anum AU - Pari A AD - Department of Cardiology, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan. FAU - Farooq, Iqra AU - Farooq I AD - Department of Pediatric Surgery, Children's Hospital, Lahore, Pakistan. FAU - Tahir, Zaryab AU - Tahir Z AD - Department of Medicine, Gujrat Medical College, Gujrat, Pakistan. FAU - Tahir, Arbaz AU - Tahir A AD - Department of Medicine, Chughtai Lab, Lahore, Pakistan. FAU - Iqbal, Qurrat Ul Ain AU - Iqbal QUA AD - Department of Medicine, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan. FAU - Arshad, Ali AU - Arshad A AD - Department of Cardiology, Punjab Institute of Cardiology, Lahore, Pakistan. FAU - Mujtaba, Muhammad Athar AU - Mujtaba MA AD - Department of Medicine, Central Park Medical College, Lahore, Pakistan. FAU - Batool, Ifrah AU - Batool I AD - Department of Medicine, Independent University Hospital, Faislabad, Pakistan. FAU - Muneer, Siraj Ul AU - Muneer SU AD - Department of Medicine, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan. FAU - Rafique, Sundas AU - Rafique S AD - Department of Hematology Oncology, Mayo Hospital, Lahore, Pakistan. FAU - Khalil, Musa AU - Khalil M AD - Department of Internal Medicine, Howard University Hospital, Washington, USA. FAU - Awais, Fatima AU - Awais F AUID- ORCID: 0009-0003-2439-8404 AD - Department of Internal Medicine, King Edward Medical University, Lahore, Pakistan. FAU - Saboor, Qazi Abdul AU - Saboor QA AD - Department of Cardiology, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan. FAU - Ashraf, Moneeb AU - Ashraf M AD - Department of Pharmacology, King Edward Medical University, Lahore, Pakistan. FAU - Ashraf, Shoaib AU - Ashraf S AD - Department of Biomedical Sciences, Ross University School of Veterinary Medicine (RUSVM), Saint Kitts and Nevis, West Indies. LA - eng PT - Comparative Study PT - Journal Article DEP - 20251215 PL - United States TA - Catheter Cardiovasc Interv JT - Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions JID - 100884139 SB - IM MH - Humans MH - Male MH - Female MH - Middle Aged MH - *Acute Coronary Syndrome/diagnostic imaging/therapy MH - *Angina, Stable/diagnostic imaging/therapy MH - Prospective Studies MH - *Coronary Angiography/methods MH - Aged MH - Predictive Value of Tests MH - Adult MH - Aged, 80 and over MH - Severity of Illness Index MH - Risk Factors MH - Adolescent MH - Young Adult MH - *Coronary Artery Disease/diagnostic imaging/therapy MH - Pakistan MH - Prognosis MH - Risk Assessment MH - *Coronary Vessels/diagnostic imaging OTO - NOTNLM OT - ACS OT - CAD OT - CYP2C19 OT - SYNTAX EDAT- 2025/12/16 06:28 MHDA- 2026/03/07 06:39 CRDT- 2025/12/16 01:05 PHST- 2025/11/24 00:00 [revised] PHST- 2025/10/10 00:00 [received] PHST- 2025/12/03 00:00 [accepted] PHST- 2026/03/07 06:39 [medline] PHST- 2025/12/16 06:28 [pubmed] PHST- 2025/12/16 01:05 [entrez] AID - 10.1002/ccd.70420 [doi] PST - ppublish SO - Catheter Cardiovasc Interv. 2026 Mar;107(4):949-954. doi: 10.1002/ccd.70420. Epub 2025 Dec 15. PMID- 41398604 OWN - NLM STAT- MEDLINE DCOM- 20251216 LR - 20251230 IS - 1745-6215 (Electronic) IS - 1745-6215 (Linking) VI - 26 IP - 1 DP - 2025 Dec 15 TI - Social ecological model for developing health-promoting schools and improving healthy eating in female students: a mixed-method protocol study in Iran. PG - 566 LID - 10.1186/s13063-025-09278-8 [doi] LID - 566 AB - BACKGROUND: The concept of health-promoting schools, initiated by the World Health Organization, aims to move beyond individual behavior change and includes changes in the organizational structure, such as improvements in the physical and social environment of the school. By integrating health promotion into all aspects of life, health-promoting schools aim to equip students with the knowledge, skills, and supportive environment required to make healthy choices and develop lifelong healthy behaviors. The present study will aim to apply the social-ecological model in establishing health-promoting schools and improving healthy eating behavior in female students on the basis of social cognitive theory (SCT) in Bastak County, Hormozgan Province, southern Iran. METHODS: The present exploratory mixed-methods study will be conducted in four phases: qualitative, instrumental, cross-sectional, and interventional. The qualitative phase will continue until data saturation. On the basis of the concepts that will be extracted in the qualitative phase, the SCT questionnaire will be designed and psychometrically validated. In the cross-sectional phase, effective factors for establishing a health-promoting school and promoting healthy eating behaviors will be identified, and in the intervention phase, necessary interventions will be designed in accordance with health promotion strategies and will be implemented in the selected school serving as the intervention group. To evaluate the impact of the intervention, both intervention and control groups will be assessed in terms of healthy eating behavior before and 3 months after the intervention. The social-ecological model will be employed as the guiding framework for the development and implementation of school-based health promotion interventions throughout the study. DISCUSSION: The aim of this study will be to design a program to establish a health-promoting school and improve healthy eating behaviors in students on the basis of the Health-Promoting School Checklist and the SCT model. The social-ecological model will also be used as a guiding framework in the design and implementation of the school-based interventions. The outcomes of this intervention will contribute to a deeper understanding of the factors that will influence the promotion of healthy eating behaviors in students. The findings will be effective in the process of developing health-promoting schools and fostering healthy eating behaviors in adolescents. TRIAL REGISTRATION: Iranian Registry of Clinical Trials IRCT20241123063812N1. Registered on 14 May 2025. CI - (c) 2025. The Author(s). FAU - Pourjalil, Farzaneh AU - Pourjalil F AD - Student Research Committee, Faculty of Health, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. FAU - Shahabi, Nahid AU - Shahabi N AD - Department of Health Education and Health Promotion, School of Health, Social Determinants in Health Promotion Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. FAU - Hosseini, Zahra AU - Hosseini Z AD - Department of Health Education and Health Promotion, School of Health, Social Determinants in Health Promotion Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. hosseinishirin@ymail.com. FAU - Aghamolaei, Teamur AU - Aghamolaei T AD - Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20251215 PL - England TA - Trials JT - Trials JID - 101263253 SB - IM MH - Humans MH - Female MH - Iran MH - *Diet, Healthy MH - *Health Promotion/methods/organization & administration MH - *School Health Services/organization & administration MH - Cross-Sectional Studies MH - Adolescent MH - *Students/psychology MH - Child MH - *Social Environment MH - Health Knowledge, Attitudes, Practice MH - *Adolescent Behavior MH - Health Behavior MH - Feeding Behavior MH - Child Behavior MH - Schools PMC - PMC12707007 OTO - NOTNLM OT - Ecological model of health OT - Health-promoting schools OT - Healthy eating behavior OT - Social cognitive theory COIS- Declarations. Ethics approval and consent to participate 24: All methods will be performed in accordance with the Declaration of Helsinki. The study was approved by the Ethics Committee of Hormozgan University of Medical Sciences (ethical code IR.HUMS.REC.1403.270). All participants provided written consent to participate in this study. Consent for publication 32: This is not applicable, as no identifying images or other personal or clinical details of the participants are presented here or will be presented in reports of the trial results. Informed consent materials are available from the corresponding author upon request. Competing interests 28: The authors declare that they have no competing interests. EDAT- 2025/12/16 06:29 MHDA- 2025/12/16 06:30 PMCR- 2025/12/15 CRDT- 2025/12/16 00:38 PHST- 2025/05/23 00:00 [received] PHST- 2025/10/30 00:00 [accepted] PHST- 2025/12/16 06:30 [medline] PHST- 2025/12/16 06:29 [pubmed] PHST- 2025/12/16 00:38 [entrez] PHST- 2025/12/15 00:00 [pmc-release] AID - 10.1186/s13063-025-09278-8 [pii] AID - 9278 [pii] AID - 10.1186/s13063-025-09278-8 [doi] PST - epublish SO - Trials. 2025 Dec 15;26(1):566. doi: 10.1186/s13063-025-09278-8. PMID- 41398496 OWN - NLM STAT- MEDLINE DCOM- 20260102 LR - 20260118 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2025 Dec 16 TI - Prevalence and factors associated with regular fast-food consumption among adults in the UAE: a cross-sectional study. PG - e2 LID - 10.1017/S1368980025101560 [doi] LID - e2 AB - OBJECTIVES: To assess the prevalence and identify sociodemographic predictors of regular fast-food consumption (R-FFC) among United Arab Emirates (UAE) adults to inform public health nutrition responses to growing diet-related ill health in the region. DESIGN: This is a descriptive cross-sectional study using purposive, convenience sampling. Data were collected using an online survey adapted from two validated surveys and distributed via social media platforms. R-FFC was defined as visiting a fast-food restaurant to eat >/= 2 times/week. Pearson's chi(2) tests and multiple binary logistic regression models were used to investigate prevalence and predictors of R-FFC. All statistical significance was considered at P-value < 0.05. SETTING: Community, adults living in the UAE. PARTICIPANTS: UAE residents, >/= 18 years, who consumed fast food >/= once during the previous month. RESULTS: Totally, 320 respondents met the inclusion criteria (age = mean 23.7 (sd 7.7) years). The prevalence of R-FFC was 46.6 %. Based on results from the regression model, predictors of R-FFC were being female (AOR 2.47; 95 % CI 1.06, 5.79), married (AOR 3.11; 95 % CI 1.25, 7.77), BMI >/= 25.0 (AOR 2.09; 95 % CI 1.10, 4.00) and residing outside Abu Dhabi (AOR 32.79; 95 % CI 12.06, 89.16). None of the remaining variables reached statistical significance. Taste was the most common reason for FFC (56.9 %), followed by convenience (21.6 %). Regular fast-food consumers were more likely to 'super-size' meals (P = 0.011), eat alone (P = 0.009) and not have regular meal patterns (P = 0.004). CONCLUSIONS: The study revealed a high prevalence of R-FFC among UAE adults, and novel cultural predictors and characteristics of FFC in this context, highlighting the importance of socially and culturally informed research and public health strategies in this region. FAU - Al Rajabi, Ala AU - Al Rajabi A AUID- ORCID: 0000-0003-2426-6279 AD - Department of Nutrition Sciences, College of Health Science, QU Health, Qatar University, Doha, Qatar. FAU - Hijazi, Rafiq AU - Hijazi R AD - Department of Mathematics and Statistics, College of Natural and Health Sciences, Zayed University, Abu Dhabi, UAE. FAU - Kennedy, Lynne Alexandra AU - Kennedy LA AUID- ORCID: 0000-0002-4699-2602 AD - Department of Health Sciences, College of Natural and Health Sciences, https://ror.org/03snqfa66Zayed University, Abu Dhabi, UAE. LA - eng PT - Journal Article DEP - 20251216 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - United Arab Emirates/epidemiology MH - Cross-Sectional Studies MH - Female MH - Male MH - Adult MH - *Fast Foods/statistics & numerical data MH - Prevalence MH - Young Adult MH - *Diet/statistics & numerical data MH - *Feeding Behavior MH - Middle Aged MH - Adolescent MH - Surveys and Questionnaires MH - Restaurants/statistics & numerical data MH - Socioeconomic Factors PMC - PMC12809606 OTO - NOTNLM OT - Dietary habits OT - Fast food OT - Non-communicable diseases OT - Obesity OT - Public health OT - Regular fast-food consumption OT - UAE COIS- The authors declare no competing interests. EDAT- 2025/12/16 06:29 MHDA- 2026/01/02 06:29 PMCR- 2025/12/16 CRDT- 2025/12/16 00:12 PHST- 2026/01/02 06:29 [medline] PHST- 2025/12/16 06:29 [pubmed] PHST- 2025/12/16 00:12 [entrez] PHST- 2025/12/16 00:00 [pmc-release] AID - S1368980025101560 [pii] AID - 10.1017/S1368980025101560 [doi] PST - epublish SO - Public Health Nutr. 2025 Dec 16;29(1):e2. doi: 10.1017/S1368980025101560. PMID- 41398348 OWN - NLM STAT- MEDLINE DCOM- 20260116 LR - 20260118 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2025 Dec 15 TI - Proteome-wide mendelian randomization reveals circulating proteins causally associated with childhood body mass index. PG - 2093 LID - 10.1038/s41598-025-31836-y [doi] LID - 2093 AB - Childhood obesity is a major public health problem, affecting one in 5 youths. We aimed to characterize biomarkers for pediatric obesity among circulating proteins using Mendelian randomization (MR). We utilized genome-wide significant cis-protein quantitative trait loci (pQTL) from three large adult proteomic GWAS (N total>58,000) and a small childhood proteomic GWAS (N=2,147) as genetic instruments for circulating protein levels. Using two-sample Mendelian randomization, we estimated causal effects of the circulating proteins on childhood body mass index (BMI) in a European GWAS of 39,620 children. MR Wald ratios were calculated to estimate the causal effect of each protein on childhood BMI. Sensitivity analyses testing the MR assumptions included colocalization and phenome-wide association studies (PheWAS). Replication was conducted using independent GWAS datasets, complemented by reverse MR and tissue enrichment analyses. Among 535 tested proteins, three colocalized and demonstrated decreasing effects on BMI per standard deviation increase in their level: endoglin (ENG; MR beta: -0.07, 95% CI [-0.10, -0.04], P=4.4x10(-)(5)), fatty acid binding protein 4 (FABP4; MR beta: -0.33, 95% CI [-0.50, -0.16], P=1.3x10(-)(4)), and cell adhesion molecule 1 (CADMI1; MR beta: -0.26, 95% CI [-0.37, -0.15], P=5.45x10(-)(5)). All three proteins showed evidence of colocalization (posterior probability >75%) and were identified using adult proteomic GWAS, given a limited statistical power using the pediatric proteomic GWAS data. Reverse causation was identified for FABP4, suggesting a compensatory mechanism. In conclusion, we identified three circulating proteins as potential blood biomarkers or drug targets for pediatric obesity, warranting further functional validation to elucidate biological mechanisms and assess therapeutic potential. CI - (c) 2025. The Author(s). FAU - Avocegamou, Raphael AU - Avocegamou R AD - Azrieli Research Center of the Sainte-Justine University Hospital, CHU Sainte Justine, Universite de Montreal, 3175 Cote-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada. AD - Department of Biochemistry and Molecular Medicine, Universite de Montreal, CHU Sainte Justine, 3175 Cote-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada. FAU - Jumentier, Basile AU - Jumentier B AD - Azrieli Research Center of the Sainte-Justine University Hospital, CHU Sainte Justine, Universite de Montreal, 3175 Cote-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada. FAU - Fagbemi, Kaossarath AU - Fagbemi K AD - Azrieli Research Center of the Sainte-Justine University Hospital, CHU Sainte Justine, Universite de Montreal, 3175 Cote-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada. FAU - Yazdanpanah, Nahid AU - Yazdanpanah N AD - Azrieli Research Center of the Sainte-Justine University Hospital, CHU Sainte Justine, Universite de Montreal, 3175 Cote-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada. FAU - Yazdanpanah, Mojgan AU - Yazdanpanah M AD - Azrieli Research Center of the Sainte-Justine University Hospital, CHU Sainte Justine, Universite de Montreal, 3175 Cote-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada. FAU - Gamache, Isabel AU - Gamache I AD - Azrieli Research Center of the Sainte-Justine University Hospital, CHU Sainte Justine, Universite de Montreal, 3175 Cote-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada. FAU - Manousaki, Despoina AU - Manousaki D AD - Azrieli Research Center of the Sainte-Justine University Hospital, CHU Sainte Justine, Universite de Montreal, 3175 Cote-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada. despina.manousaki@umontreal.ca. AD - Department of Biochemistry and Molecular Medicine, Universite de Montreal, CHU Sainte Justine, 3175 Cote-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada. despina.manousaki@umontreal.ca. AD - Department of Pediatrics, Universite de Montreal, CHU Sainte Justine, 3175 Cote-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada. despina.manousaki@umontreal.ca. LA - eng GR - 2025-2026 - CC - 366931/Fonds de Recherche du Quebec - Sante/ PT - Journal Article DEP - 20251215 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Proteome) RN - 0 (Blood Proteins) RN - 0 (Biomarkers) RN - 0 (Fatty Acid-Binding Proteins) SB - IM MH - Humans MH - *Mendelian Randomization Analysis MH - *Body Mass Index MH - Child MH - Genome-Wide Association Study MH - *Pediatric Obesity/genetics/blood MH - Male MH - *Proteome/genetics MH - Female MH - Quantitative Trait Loci MH - *Blood Proteins/genetics MH - Proteomics/methods MH - Biomarkers/blood MH - Fatty Acid-Binding Proteins/blood/genetics MH - Polymorphism, Single Nucleotide MH - Adolescent PMC - PMC12808636 OTO - NOTNLM OT - Causal inference OT - Mendelian randomization OT - Pediatric obesity OT - Proteins COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/12/16 00:35 MHDA- 2026/01/17 04:07 PMCR- 2025/12/15 CRDT- 2025/12/15 23:44 PHST- 2025/07/19 00:00 [received] PHST- 2025/12/05 00:00 [accepted] PHST- 2026/01/17 04:07 [medline] PHST- 2025/12/16 00:35 [pubmed] PHST- 2025/12/15 23:44 [entrez] PHST- 2025/12/15 00:00 [pmc-release] AID - 10.1038/s41598-025-31836-y [pii] AID - 31836 [pii] AID - 10.1038/s41598-025-31836-y [doi] PST - epublish SO - Sci Rep. 2025 Dec 15;16(1):2093. doi: 10.1038/s41598-025-31836-y. PMID- 41396243 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260904 IS - 1920-7476 (Electronic) IS - 0008-4263 (Print) IS - 0008-4263 (Linking) VI - 117 IP - 4 DP - 2026 Aug TI - Identifying patients with obesity from health administrative data: Diagnostic accuracy of surgical billing claims. PG - 753-763 LID - 10.17269/s41997-025-01114-5 [doi] AB - OBJECTIVES: Obesity (body mass index, BMI >/= 30 kg/m(2)) is a predictor of patient outcomes across surgical disciplines, but is not accurately captured by diagnostic codes in administrative databases. The objective of this study was to determine the validity of surgeon and anaesthetist billing claims indicating that their patients had concurrent class III obesity (BMI > 40) as compared to patients' self-reported BMI. METHODS: We performed a cross-sectional study of adult patients who had undergone major abdominopelvic, neck, and hip surgery in Ontario from 2011 to 2019, and had also reported their BMI on either the Canadian Community Health Survey or the Ontario Health Study. Physician billing claims for class III obesity were compared to self-reported BMI, and measures of diagnostic accuracy with 95% confidence intervals were calculated. RESULTS: We identified 52,515 patients who had undergone surgery (80.6% abdominopelvic; 19.4% neck/hip) with median age 57 years and median BMI 26 (range 15-108); 2189 patients (4.2%) reported a BMI > 40. When self-reported BMI was collected within 1 year of surgery, billing claims submitted by either the surgeon, surgical assistant, or anaesthetist had sensitivity 82.9% (95% CI 79.1-86.7), specificity 95.5% (95.0-96.0), positive predictive value 52.9% (50.1-58.5), and negative predictive value 98.9% (98.7-99.2) for the identification of BMI > 40. Positive predictive value for the identification of BMI > 30 was 95.4% (93.7-97.0). CONCLUSION: Physician billing claims are specific and sensitive for the identification of patients with BMI > 40 undergoing surgery, enable accurate selection of a population with BMI > 30, and are valid for use in studies conducted with health administrative data. CI - (c) 2025. The Author(s) under exclusive license to The Canadian Public Health Association. FAU - Cusimano, Maria C AU - Cusimano MC AUID- ORCID: 0000-0002-1661-4846 AD - Department of Obstetrics & Gynecology, University of Toronto, Toronto, ON, Canada. AD - Lahey Hospital & Medical Center, Beth Israel Lahey Health, Burlington, MA, USA. FAU - Baxter, Nancy N AU - Baxter NN AD - ICES (Formerly the Institute for Clinical Evaluative Sciences), Toronto, ON, Canada. AD - Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. AD - Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia. FAU - Moineddin, Rahim AU - Moineddin R AD - ICES (Formerly the Institute for Clinical Evaluative Sciences), Toronto, ON, Canada. AD - Department of Family & Community Medicine, University of Toronto, Toronto, ON, Canada. FAU - Chiu, Maria AU - Chiu M AD - ICES (Formerly the Institute for Clinical Evaluative Sciences), Toronto, ON, Canada. AD - Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. FAU - Nguyen, Lena AU - Nguyen L AD - ICES (Formerly the Institute for Clinical Evaluative Sciences), Toronto, ON, Canada. FAU - Aktar, Suriya AU - Aktar S AD - ICES (Formerly the Institute for Clinical Evaluative Sciences), Toronto, ON, Canada. FAU - Liu, Ning AU - Liu N AD - ICES (Formerly the Institute for Clinical Evaluative Sciences), Toronto, ON, Canada. FAU - Simpson, Andrea N AU - Simpson AN AD - Department of Obstetrics & Gynecology, University of Toronto, Toronto, ON, Canada. AD - Department of Obstetrics & Gynecology, Unity Health Toronto, St. Michael's Hospital, Toronto, ON, Canada. FAU - Johnson, Christina AU - Johnson C AD - Lahey Hospital & Medical Center, Beth Israel Lahey Health, Burlington, MA, USA. FAU - Ferguson, Sarah E AU - Ferguson SE AD - Department of Obstetrics & Gynecology, University of Toronto, Toronto, ON, Canada. sarah.ferguson@uhn.ca. AD - Division of Gynecologic Oncology, Princess Margaret Cancer Centre/Sinai Health Systems, Toronto, ON, Canada. sarah.ferguson@uhn.ca. LA - eng PT - Journal Article DEP - 20251215 PL - Switzerland TA - Can J Public Health JT - Canadian journal of public health = Revue canadienne de sante publique JID - 0372714 SB - IM MH - Humans MH - Female MH - Middle Aged MH - Male MH - Ontario/epidemiology MH - Cross-Sectional Studies MH - Adult MH - Body Mass Index MH - Aged MH - *Obesity/diagnosis/epidemiology MH - Young Adult MH - Adolescent MH - *Surgical Procedures, Operative/statistics & numerical data MH - *Insurance Claim Review MH - Databases, Factual MH - Self Report PMC - PMC13536496 OTO - NOTNLM OT - Anaesthetists OT - Body mass index OT - Obesity OT - Predictive value of tests OT - Routinely collected health data OT - Surgeons COIS- Declarations. Ethics approval: The Research Ethics Board at the University of Toronto (Toronto, ON, Canada) provided approval (#38212). Consent to participate: Not applicable. Consent for publication: Not applicable. Conflict of interest: The authors declare no competing interests. EDAT- 2025/12/15 13:10 MHDA- 2026/09/01 17:39 PMCR- 2026/12/15 CRDT- 2025/12/15 11:06 PHST- 2025/06/02 00:00 [received] PHST- 2025/09/09 00:00 [accepted] PHST- 2026/09/01 17:39 [medline] PHST- 2025/12/15 13:10 [pubmed] PHST- 2025/12/15 11:06 [entrez] PHST- 2026/12/15 00:00 [pmc-release] AID - 10.17269/s41997-025-01114-5 [pii] AID - 1114 [pii] AID - 10.17269/s41997-025-01114-5 [doi] PST - ppublish SO - Can J Public Health. 2026 Aug;117(4):753-763. doi: 10.17269/s41997-025-01114-5. Epub 2025 Dec 15. PMID- 41396232 OWN - NLM STAT- MEDLINE DCOM- 20251215 LR - 20261010 IS - 1534-3081 (Electronic) IS - 1534-3081 (Linking) VI - 30 IP - 1 DP - 2025 Dec 15 TI - Assessment and Non-pharmacological Management of Chronic Pain in Pediatric Cancer Survivors: Current Practices and Recommendations for Next Steps. PG - 1 LID - 10.1007/s11916-025-01446-4 [doi] AB - PURPOSE OF REVIEW: Chronic pain is a prevalent and debilitating late effect of pediatric cancer. It is also multifaceted and requires comprehensive assessment to guide optimal treatment. While pharmacological interventions for chronic pain in this population are well summarized elsewhere, a current review of less invasive non-pharmacological interventions and assessments to guide them is needed. RECENT FINDINGS: Recent research has found the utility of biopsychosocial assessment of pain in pediatric cancer survivors using both validated measures such as the PROMIS and brief screeners. For intervention, preliminary studies found positive outcomes for physical activity interventions and biofeedback for pain in survivors. Advances in management of chronic pain in survivors are promising, though future research should refine identification and treatment. More research is needed on comprehensive biopsychosocial pain assessments and tailoring treatment. Further, promising interventions in broad chronic pain literature such as hypnosis should be explored for pediatric cancer survivors. CI - (c) 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Hayes, Lauren AU - Hayes L AD - Norton Children's Medical Group, Louisville, KY, USA. Lauren.Hayes@louisville.edu. AD - Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY, USA. Lauren.Hayes@louisville.edu. FAU - Pabis, Jacqueline M AU - Pabis JM AD - Norton Children's Medical Group, Louisville, KY, USA. AD - Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY, USA. FAU - Millmann, Megan AU - Millmann M AD - Norton Children's Medical Group, Louisville, KY, USA. AD - Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY, USA. FAU - Milligan, Claire Niehaus AU - Milligan CN AD - Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. FAU - Daffin, Morgan AU - Daffin M AD - Norton Children's Medical Group, Louisville, KY, USA. AD - Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY, USA. LA - eng PT - Journal Article PT - Review DEP - 20251215 PL - United States TA - Curr Pain Headache Rep JT - Current pain and headache reports JID - 100970666 SB - IM MH - Humans MH - *Chronic Pain/therapy/diagnosis/etiology MH - Child MH - *Pain Management/methods MH - *Cancer Survivors MH - *Neoplasms/complications MH - Pain Measurement/methods OTO - NOTNLM OT - Assessment OT - Chronic pain OT - Non-pharmacological management OT - Pediatric cancer OT - Survivorship COIS- Declarations. Competing interests: The authors declare no competing interests. Human and animal rights: This article does not contain any studies with human or animal subjects performed by any of the authors. Disclosure: The authors have no relevant financial or non-financial conflicts of interests to disclose. EDAT- 2025/12/15 13:10 MHDA- 2025/12/15 13:11 CRDT- 2025/12/15 11:06 PHST- 2025/07/30 00:00 [received] PHST- 2025/11/20 00:00 [accepted] PHST- 2025/12/15 13:11 [medline] PHST- 2025/12/15 13:10 [pubmed] PHST- 2025/12/15 11:06 [entrez] AID - 10.1007/s11916-025-01446-4 [pii] AID - 10.1007/s11916-025-01446-4 [doi] PST - epublish SO - Curr Pain Headache Rep. 2025 Dec 15;30(1):1. doi: 10.1007/s11916-025-01446-4. PMID- 41393747 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251215 LR - 20251217 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 17 IP - 11 DP - 2025 Nov TI - When Formulas Fail: A Secondary Analysis of Dual-Energy X-ray Absorptiometry (DXA) Body Composition Data Comparing Ideal and Lean Body Weight Equations Against Measured Lean Body Weight in Obese Children. PG - e96759 LID - 10.7759/cureus.96759 [doi] LID - e96759 AB - Background Accurate weight-based drug dosing in obese children is essential for safe and effective therapy, yet the relationships between ideal body weight (IBW), lean body weight (LBW), and actual body composition remain poorly defined. IBW was originally developed to assess nutritional status rather than guide drug dosing, but it is often used as a surrogate for LBW despite limited validation. This study aimed to compare commonly used IBW and LBW formulas against measured LBW to evaluate their accuracy and clinical applicability in obese children. Methods A secondary analysis was conducted using data from 30 obese children (BMI-for-age Z-score >/=2.0) obtained in a hospital-based pediatric body composition study. Anthropometric data and dual-energy X-ray absorptiometry (DXA) measurements of LBW were available. Seven published equations for IBW and LBW estimation were evaluated. Accuracy was assessed using mean percentage error, root mean square percentage error, and proportions of estimates within 10% (P10) and 20% (P20) of measured LBW. Results All IBW formulas substantially overestimated measured LBW, with mean biases ranging from 18% to 30%, and none achieved acceptable accuracy (P10 <70%). Among LBW equations, the Foster formula demonstrated the highest accuracy, while the Peters and Callaghan methods performed poorly. Adjusting IBW formulas with simple correction factors improved LBW prediction accuracy, though similar corrections were not feasible for the Peters and Callaghan methods. Conclusions IBW formulas cannot reliably substitute for LBW in obese children without modification. The Foster equation offers the best accuracy for LBW estimation, while the BMI(5)(0) IBW method shows potential for adaptation in clinical tools. Further validation of hybrid or adjusted models is required to optimize pediatric drug dosing safety. CI - Copyright (c) 2025, Wells et al. FAU - Wells, Mike AU - Wells M AD - Department of Emergency Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA. FAU - Goldstein, Lara N AU - Goldstein LN AD - Department of Emergency Medicine, Memorial Healthcare System, Hollywood, USA. LA - eng PT - Journal Article DEP - 20251113 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC12701679 OTO - NOTNLM OT - foster formula OT - ideal body weight OT - lean body weight OT - mclaren formula OT - moore formula OT - pediatric weight estimation OT - peters formula COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. The Human Research Ethics Committee of the University of the Witwatersrand issued approval M1511107. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2025/12/15 13:10 MHDA- 2025/12/15 13:11 PMCR- 2025/11/13 CRDT- 2025/12/15 06:11 PHST- 2025/11/13 00:00 [accepted] PHST- 2025/12/15 13:11 [medline] PHST- 2025/12/15 13:10 [pubmed] PHST- 2025/12/15 06:11 [entrez] PHST- 2025/11/13 00:00 [pmc-release] AID - 10.7759/cureus.96759 [doi] PST - epublish SO - Cureus. 2025 Nov 13;17(11):e96759. doi: 10.7759/cureus.96759. eCollection 2025 Nov. PMID- 41392119 OWN - NLM STAT- MEDLINE DCOM- 20260120 LR - 20260123 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2025 Dec 15 TI - Global diet quality score (GDQS) favorably affects blood pressure, serum lipids, lipid accumulation product and attenuates inflammation among obese individuals. PG - 2569 LID - 10.1038/s41598-025-32538-1 [doi] LID - 2569 AB - The Global Diet Quality Score (GDQS) is a recently developed food-based index that evaluates both healthy and unhealthy dietary components and has been linked to non-communicable disease risk. However, limited evidence exists regarding its relationship with metabolic and inflammatory markers among obese individuals. This study aimed to examine the association between GDQS and cardio-metabolic risk factors, lipid accumulation product (LAP), and systemic inflammation in obese adults. In this cross-sectional study, 302 obese participants (body mass index [BMI] >/= 30 kg/m(2)) aged 18-50 years were recruited. Dietary intake was assessed using a validated food frequency questionnaire, and GDQS was calculated from 25 food groups. Anthropometric indices, blood pressure, fasting blood glucose, lipid profile, hemoglobin (Hb) A1c, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), high sensitive C-reactive protein (hs-CRP), and LAP were measured. Participants were classified into tertiles of GDQS, and differences in metabolic parameters across tertiles were analyzed using analysis of covariance and multinomial regression models, adjusting for potential confounders. Higher GDQS tertiles were associated with significantly lower systolic blood pressure (P = 0.048), total cholesterol, triglycerides (both P < 0.05), hs-CRP (P < 0.001), and LAP (P = 0.026). No significant associations were observed between GDQS and other parameters. Greater adherence to a high-quality diet, as reflected by GDQS, is linked to favorable lipid profiles, reduced inflammation, and lower LAP in obese adults. These findings support the GDQS as a valuable tool for assessing diet quality and highlight the importance of dietary improvement in managing obesity-related metabolic risk. CI - (c) 2025. The Author(s). FAU - El-Sehrawy, Amr Ali Mohamed Abdelgawwad AU - El-Sehrawy AAMA AD - Department of Internal Medicine, Diabetes, Endocrinology and Metabolism, Mansoura University, Mansoura, Egypt. FAU - Mohammad, Suleiman Ibrahim AU - Mohammad SI AD - Electronic Marketing and Social Media, Economic and Administrative Sciences Zarqa University, Zarqa, Jordan. AD - Research follower, INTI International University, 71800, Nilai, Negeri Sembilan, Malaysia. FAU - Hussain, Wan Mohd Hirwani Wan AU - Hussain WMHW AD - Graduate School of Business, Universiti Kebangsaan Malaysia, 43600, Bangi, Selangor, Malaysia. FAU - Prasad, K D V AU - Prasad KDV AD - Symbiosis Institute of Business Management, Hyderabad, Symbiosis International (Deemed University), Pune, India. FAU - Vasudevan, Asokan AU - Vasudevan A AD - Faculty of Business and Communications, INTI International University, 71800, Nilai, Negeri Sembilan, Malaysia. AD - Shinawatra University, 99 Moo 10, Bangtoey, Samkhok, Pathum Thani, 12160, Thailand. FAU - Maashi, Marwah Suliman AU - Maashi MS AD - Medical Laboratory Sciences Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, 21589, Saudi Arabia. AD - Regenerative Medicine Unit, King Fahd Medical Research Centre, King Abdulaziz University, Jeddah, 21589, Saudi Arabia. FAU - Hsu, Chou-Yi AU - Hsu CY AD - Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan, 71710, Taiwan. t545316@gmail.com. FAU - Al-Khafaji, Zahraa Khudhair Abbas AU - Al-Khafaji ZKA AD - College of pharmacy, the Islamic University, Najaf, Iraq. AD - Department of medical analysis, Medical laboratory technique college, the Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq. FAU - Al-Mashhadani, Zuhair I AU - Al-Mashhadani ZI AD - Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq. FAU - Jafarzadeh, Faria AU - Jafarzadeh F AD - Department of Internal Medicine, North Khorasan University of Medical Sciences, Bojnourd, Iran. f.jafarzadeh@nkums.ac.ir. LA - eng PT - Journal Article DEP - 20251215 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Lipids) RN - 9007-41-4 (C-Reactive Protein) SB - IM MH - Humans MH - *Obesity/blood/physiopathology MH - Adult MH - Female MH - Male MH - *Blood Pressure MH - Middle Aged MH - *Inflammation/blood MH - *Lipids/blood MH - Adolescent MH - Young Adult MH - Cross-Sectional Studies MH - *Diet MH - *Lipid Accumulation Product MH - Body Mass Index MH - C-Reactive Protein/metabolism PMC - PMC12819469 OTO - NOTNLM OT - GDQS OT - Global diet quality score OT - Inflammation OT - Metabolic profile OT - Obesity COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: The current work has been ethically approved by the UKM-GSB, grant number GSB-2025-007 funded by the Graduate School of Business, UKM. The work was performed under guidelines of declaration of Helsinki and all of the subjects had signed the written informed consent before participation in the study. Consent for publication: Not applicable. EDAT- 2025/12/15 00:28 MHDA- 2026/01/21 01:48 PMCR- 2025/12/15 CRDT- 2025/12/14 23:10 PHST- 2025/09/28 00:00 [received] PHST- 2025/12/10 00:00 [accepted] PHST- 2026/01/21 01:48 [medline] PHST- 2025/12/15 00:28 [pubmed] PHST- 2025/12/14 23:10 [entrez] PHST- 2025/12/15 00:00 [pmc-release] AID - 10.1038/s41598-025-32538-1 [pii] AID - 32538 [pii] AID - 10.1038/s41598-025-32538-1 [doi] PST - epublish SO - Sci Rep. 2025 Dec 15;16(1):2569. doi: 10.1038/s41598-025-32538-1. PMID- 41391732 OWN - NLM STAT- MEDLINE DCOM- 20260307 LR - 20260803 IS - 1878-5921 (Electronic) IS - 0895-4356 (Linking) VI - 191 DP - 2026 Mar TI - Factors influencing use and choice of Core Outcome Sets and Outcome Measurement Instruments in trials of interventions to prevent childhood obesity: a mixed-methods survey. PG - 112105 LID - S0895-4356(25)00438-X [pii] LID - 10.1016/j.jclinepi.2025.112105 [doi] AB - BACKGROUND AND OBJECTIVE: Heterogeneity in what and how outcomes are measured in childhood obesity prevention trials limits evidence synthesis and evaluation of intervention effectiveness. Core Outcome Sets (COS) and Core Outcome Measurement Sets (COMS) can standardize measurement and reporting across trials, but only if they are used by trialists. This study examined trialists' awareness and attitudes toward two childhood obesity-related COS and factors influencing their use; characteristics of Outcome Measurement Instruments (OMIs) used in childhood obesity prevention trials; and how trialists choose these OMIs. METHODS: An online, international, cross-sectional survey was conducted including trialists engaged in designing and/or conducting childhood obesity prevention trials in children aged 0-5 years. Trialists were recruited via peer-reviewed publications, the Transforming Obesity Prevention for CHILDren Collaboration and professional contacts. The survey examined trialist characteristics, awareness, and use of existing COS, OMI characteristics, and factors influencing trialist selection of OMIs. Quantitative data were analyzed descriptively; qualitative data were analyzed using content analysis. RESULTS: The majority of the 46 trialists who completed the survey were senior-career researchers (61%; n = 28), with 1 to 38 years' experience in childhood obesity prevention trials. Seventy percent (n = 32) were familiar with COS in general; 84% (n = 26) of these were familiar with one or both childhood obesity-related COS. These trialists' COS use was limited by perceived participant burden, cost, and lack of knowledge; availability of guidelines, and resources facilitated COS use. Trialists favored measuring outcomes using existing (83%; n = 38) and adapted (80%; n = 37) questionnaires, and anthropometric measures (80%; n = 37). Quantitative and qualitative data indicated that measurement properties (eg, reliability, validity), cost, perceived burden, ease of use, and feasibility were the most important factors influencing trialists' OMI choice. CONCLUSION: Trialists' awareness and use of childhood obesity-related COS is positive, and may be enhanced through provision of guidance and resources to support COS and COMS use. Development of COMS should consider trialist-reported factors related to feasibility and measurement properties. Such considerations can enhance COS and COMS use in trials, reducing outcome heterogeneity, and improving evaluation of intervention effectiveness to prevent childhood obesity. CI - Copyright (c) 2025 Elsevier Inc. All rights reserved. FAU - Looney, Eibhlin AU - Looney E AD - School of Public Health, University College Cork, Cork, County Cork, Ireland. FAU - Duffy, Moira AU - Duffy M AD - School of Public Health, University College Cork, Cork, County Cork, Ireland. FAU - Dutch, Dimity AU - Dutch D AD - School of Public Health, University College Cork, Cork, County Cork, Ireland; Flinders University, College of Nursing and Health Sciences, Caring Futures Institute, Adelaide, South Australia, Australia. FAU - Brown, Victoria AU - Brown V AD - Deakin Health Economics, Institute for Health Transformation, Deakin University, Geelong, Australia. FAU - Browne, John AU - Browne J AD - School of Public Health, University College Cork, Cork, County Cork, Ireland. FAU - Devane, Declan AU - Devane D AD - HRB Trials Methodology Research Network, and Evidence Synthesis Ireland and Cochrane Ireland, School of Nursing and Midwifery, University of Galway, Galway, County Galway, Ireland. FAU - Harrington, Janas M AU - Harrington JM AD - School of Public Health, University College Cork, Cork, County Cork, Ireland. FAU - Hayes, Catherine AU - Hayes C AD - Public Health & Primary Care, School of Medicine, The University of Dublin Trinity College, Dublin, Ireland. FAU - Johnson, Brittany J AU - Johnson BJ AD - Flinders University, College of Nursing and Health Sciences, Caring Futures Institute, Adelaide, South Australia, Australia. FAU - Kearney, Patricia M AU - Kearney PM AD - School of Public Health, University College Cork, Cork, County Cork, Ireland. FAU - Kirkham, Jamie J AU - Kirkham JJ AD - Centre for Biostatistics, The University of Manchester, Manchester Academic Health Service Centre, Manchester, England. FAU - Leahy-Warren, Patricia AU - Leahy-Warren P AD - School of Nursing and Midwifery, University College Cork, Cork, County Cork, Ireland. FAU - Murphy, Andrew W AU - Murphy AW AD - HRB Primary Care Clinical Trials Network Ireland, University of Galway, Galway, County Galway, Ireland. FAU - Redsell, Sarah AU - Redsell S AD - School of Health Sciences, University of Nottingham, Nottingham, UK. FAU - Seidler, Anna Lene AU - Seidler AL AD - Department of Child and Adolescent Psychiatry, University Medical Centre Rostock, Rostock, Germany; German Center for Child and Adolescent Health (DZKJ), Partner Site Greifswald/Rostock, Rostock, Germany. FAU - Skouteris, Helen AU - Skouteris H AD - School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. FAU - Dahly, Darren AU - Dahly D AD - HRB Clinical Research Facility Cork, School of Public Health, University College Cork, Cork, County Cork, Ireland. FAU - Matvienko-Sikar, Karen AU - Matvienko-Sikar K AD - School of Public Health, University College Cork, Cork, County Cork, Ireland. Electronic address: karen.msikar@ucc.ie. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251212 PL - United States TA - J Clin Epidemiol JT - Journal of clinical epidemiology JID - 8801383 SB - IM MH - Humans MH - *Pediatric Obesity/prevention & control MH - Cross-Sectional Studies MH - Child, Preschool MH - Male MH - Female MH - *Outcome Assessment, Health Care/methods/statistics & numerical data MH - Surveys and Questionnaires MH - Infant MH - Adult MH - Infant, Newborn OTO - NOTNLM OT - Child health behaviors OT - Childhood obesity OT - Core outcome measurement sets OT - Core outcome set OT - Outcome measurement instrument OT - Trialists COIS- Declaration of competing interest There are no competing interests for any author. EDAT- 2025/12/15 00:28 MHDA- 2026/03/07 18:38 CRDT- 2025/12/14 19:39 PHST- 2025/07/22 00:00 [received] PHST- 2025/12/02 00:00 [revised] PHST- 2025/12/08 00:00 [accepted] PHST- 2026/03/07 18:38 [medline] PHST- 2025/12/15 00:28 [pubmed] PHST- 2025/12/14 19:39 [entrez] AID - S0895-4356(25)00438-X [pii] AID - 10.1016/j.jclinepi.2025.112105 [doi] PST - ppublish SO - J Clin Epidemiol. 2026 Mar;191:112105. doi: 10.1016/j.jclinepi.2025.112105. Epub 2025 Dec 12. PMID- 41391087 OWN - NLM STAT- MEDLINE DCOM- 20251214 LR - 20251231 IS - 0004-5772 (Print) IS - 0004-5772 (Linking) VI - 73 IP - 12 DP - 2025 Dec TI - The Interplay of Age, Obesity Measures, and Micronutrient Deficiencies in PCOS-associated Metabolic Dysfunction Findings from a Retrospective Postobservational Cohort Study. PG - e8-e16 LID - 10.59556/japi.73.1281 [doi] AB - BACKGROUND: Polycystic ovary syndrome (PCOS) is a complex endocrine-metabolic disorder with significant age-related, anthropometric, and metabolic variations. Understanding the interplay between age, body composition, and micronutrient status can help identify predictors of metabolic dysfunction and long-term complications in women with PCOS. Most studies assess these factors in isolation, resulting in fragmented evidence and inconsistent conclusions. OBJECTIVES: This study aimed to evaluate the predictive associations of age, anthropometric parameters, and micronutrient levels (vitamin B12 and vitamin D3) with key metabolic, cardiovascular, and nutritional markers in women diagnosed with PCOS. MATERIALS AND METHODS: A cross-sectional analysis was conducted among women with PCOS, divided into two age-groups: group I (15-30 years) and group II (31-40 years). One-way analysis of variance (ANOVA) and linear regression analyses were performed to investigate age- and obesity-related differences in metabolic parameters. Pearson's correlations and regression models were applied to assess the predictive strength of age, body mass index (BMI), waist circumference (WC), vitamin B12, and vitamin D3 on metabolic outcomes. The Benjamini-Hochberg method was applied to control the false discovery rate (FDR) for multiple comparisons and ensure conclusions account for the increased risk of type I error due to multiple comparisons, thereby supporting the validity of the study's observations. RESULTS: The PCOS cohort exhibited generalized overweight (BMI 23.0-24.9 kg/m(2)) and obesity (BMI >/=25.0 kg/m(2)) in 40 and 54% of subjects, respectively; notably, visceral obesity (WC >/=80 cm) was present in 97% of the cohort, underscoring a marked predominance of central adiposity even among those with lower BMI thresholds. The PCOS cohort demonstrated high metabolic risk, with frequent insulin resistance, dyslipidemia, and hypertension; notably, 25% had nonalcoholic fatty liver disease (NAFLD), predominantly mild steatosis, indicating a substantial risk for future cardiometabolic complications. Advancing age was significantly associated with higher fasting blood sugar (FBS) (p = 0.019) and glycated hemoglobin (HbA1c) (p = 0.048), while fasting insulin declined with age (p = 0.048). BMI and WC were strong predictors of metabolic risk, positively impacting fasting insulin, FBS, HbA1c, and blood pressure (p < 0.05), while showing significant negative associations with high-density lipoprotein cholesterol (HDL-C) (p < 0.001). Vitamin B12 and D3 levels showed no significant impact on metabolic parameters. Vitamin B12 was predicted only by age (p < 0.001) and vitamin D3 (p < 0.001), while vitamin D3 was influenced by age (p < 0.001) and vitamin B12 levels (p = 0.041). CONCLUSION: Central obesity markers-particularly WC and BMI-are robust predictors of metabolic dysfunction in PCOS, offering greater prognostic value than micronutrient levels such as vitamin B12 or D3, which showed limited association with metabolic disturbances in this population. These findings highlight the primacy of early detection and intervention targeting adiposity and insulin resistance to reduce long-term cardiometabolic risk among women with PCOS. Integrated, multifactorial risk assessment remains essential, as age, nutritional deficits, and obesity-related factors independently and collectively drive adverse metabolic outcomes in PCOS, emphasizing the need for comprehensive preventive and management strategies. CI - (c) Journal of The Association of Physicians of India 2025. FAU - Tumbi, Zubeda AU - Tumbi Z AD - Founder and Director, Department of Clinical Dietetics, HealthWatch Nutrition Clinic, Mumbai, Maharashtra, India, Orcid: https://orcid.org/0009-0004-4915-3136, Corresponding Author. FAU - Tumbi, Mehzamah AU - Tumbi M AD - Assistant Dietitian, Department of Clinical Nutrition and Dietetics, HealthWatch Nutrition Clinic, Mumbai, Maharashtra, India. FAU - Tailor, Vaibhavi AU - Tailor V AD - Assistant Dietitian, Department of Clinical Nutrition and Dietetics, HealthWatch Nutrition Clinic, Mumbai, Maharashtra, India. FAU - Temkar, Gunjan AU - Temkar G AD - Research Assistant, Department of Information and Technology, HealthWatch Nutrition Clinic, Mumbai, Maharashtra, India. LA - eng PT - Journal Article PT - Observational Study PL - India TA - J Assoc Physicians India JT - The Journal of the Association of Physicians of India JID - 7505585 RN - 0 (Micronutrients) SB - IM MH - Humans MH - Female MH - Adult MH - *Polycystic Ovary Syndrome/complications/metabolism MH - Young Adult MH - Cross-Sectional Studies MH - Retrospective Studies MH - *Obesity/complications/epidemiology MH - Adolescent MH - Body Mass Index MH - *Micronutrients/deficiency MH - Age Factors MH - Waist Circumference EDAT- 2025/12/14 15:52 MHDA- 2025/12/14 15:53 CRDT- 2025/12/14 11:22 PHST- 2025/12/14 15:53 [medline] PHST- 2025/12/14 15:52 [pubmed] PHST- 2025/12/14 11:22 [entrez] AID - 10.59556/japi.73.1281 [doi] PST - ppublish SO - J Assoc Physicians India. 2025 Dec;73(12):e8-e16. doi: 10.59556/japi.73.1281. PMID- 41390639 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260627 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2025 Dec 13 TI - Variation in real world dementia risk profiles according to demographic characteristics in 6171 adults drawn from the Australian CogDrisk website. PG - 233 LID - 10.1186/s12889-025-25943-8 [doi] LID - 233 AB - BACKGROUND: We aimed to evaluate differences in dementia risk profiles according to age, birthplace and First Nations status. METHODS: The sample included 6171 (62% female, < 1% non-binary/other) middle-aged and older adults who self-administered the CogDrisk assessment online and consented to their data being used for research from May 2023 to May 2024. The majority were aged 40-64 ('midlife'; 67.9%) or aged 65-96 ('later-life'; 25.8%); 6.3% were aged 18-40. More than a third (36.2%) were born overseas, 95% resided in Australia, and 66.0% had a university degree. RESULTS: Key midlife risk factors were hypertension 27.7%, pesticide exposure 24.6%, high cholesterol 25.1%, head injury 15.3%, diabetes 7.6%, and atrial fibrillation (AFib) 7.3%. Key later-life risk factors were hypertension 45.4%, pesticide exposure 33.0%, AFib 18.3% head injury 16.4%, and diabetes 11.7%. Midlife respondents born in the Pacific and New Zealand (NZ) had high rates of vascular risk factors and those born in NZ reported high rates of head injury and depression. The highest rates of heavy drinking and insufficient physical activity were reported by respondents born in the UK and Asia respectively. Using published estimates from validation studies, 20% of those aged 65 + had a high dementia risk (CogDrisk score > 12). CONCLUSIONS: High rates of multiple risk factors were identified and varied according to age group and birthplace. This study provides evidence for tailoring risk reduction intervention and advice by age and birthplace. FAU - Anstey, Kaarin J AU - Anstey KJ AD - School of Psychology, University of New South Wales, Kensington, NSW, 2052, Australia. k.anstey@unsw.edu.au. AD - Neuroscience Research Australia, Randwick, NSW, Australia. k.anstey@unsw.edu.au. AD - UNSW Ageing Futures Institute, University of New South Wales, Kensington, NSW, Australia. k.anstey@unsw.edu.au. FAU - Huque, Md Hamidul AU - Huque MH AD - School of Psychology, University of New South Wales, Kensington, NSW, 2052, Australia. AD - Neuroscience Research Australia, Randwick, NSW, Australia. AD - UNSW Ageing Futures Institute, University of New South Wales, Kensington, NSW, Australia. FAU - Eramudugolla, Ranmalee AU - Eramudugolla R AD - School of Psychology, University of New South Wales, Kensington, NSW, 2052, Australia. AD - Neuroscience Research Australia, Randwick, NSW, Australia. AD - UNSW Ageing Futures Institute, University of New South Wales, Kensington, NSW, Australia. FAU - Li, Meiwei AU - Li M AD - School of Psychology, University of New South Wales, Kensington, NSW, 2052, Australia. FAU - Long, Marita AU - Long M AD - Department of General Practice and Primary Care, University of Melbourne, Parkville, VIC, Australia. FAU - Kootar, Scherazad AU - Kootar S AD - Clinical Research Centre, The Sydney Children's Hospital Network, Westmead, NSW, Australia. FAU - Cartwright, Michael AU - Cartwright M AD - Neuroscience Research Australia, Randwick, NSW, Australia. FAU - O'Connor, Claire Mc AU - O'Connor CM AD - School of Psychology, University of New South Wales, Kensington, NSW, 2052, Australia. AD - Neuroscience Research Australia, Randwick, NSW, Australia. AD - Centre for Positive Ageing, HammondCare, Hammondville, NSW, Australia. FAU - Temple, Jeromey AU - Temple J AD - Melbourne School of Population and Global Health, University of Melbourne, Carlton, VIC, Australia. LA - eng GR - FL190100011/Australian Research Council/ PT - Journal Article DEP - 20251213 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - *Dementia/epidemiology/ethnology MH - Middle Aged MH - Australia/epidemiology MH - Risk Factors MH - Aged MH - Adult MH - Aged, 80 and over MH - Male MH - Young Adult MH - Adolescent MH - Risk Assessment MH - Age Factors PMC - PMC12821871 OTO - NOTNLM OT - Community setting OT - Country of birth OT - Dementia OT - Risk factors OT - Risk profiles COIS- Declarations. Ethics approval and consent to participate: Ethics approval is provided by the University of New South Wales Human Research Ethics Committee (UNSW HREC; protocol number HC200108). All data are de-identified and stored on a secure server at Neuroscience Research Australia. All the participants provided informed consent to the original data collection. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/14 00:39 MHDA- 2026/06/27 06:43 PMCR- 2025/12/13 CRDT- 2025/12/13 23:21 PHST- 2024/10/28 00:00 [received] PHST- 2025/12/05 00:00 [accepted] PHST- 2026/06/27 06:43 [medline] PHST- 2025/12/14 00:39 [pubmed] PHST- 2025/12/13 23:21 [entrez] PHST- 2025/12/13 00:00 [pmc-release] AID - 10.1186/s12889-025-25943-8 [pii] AID - 25943 [pii] AID - 10.1186/s12889-025-25943-8 [doi] PST - epublish SO - BMC Public Health. 2025 Dec 13;26(1):233. doi: 10.1186/s12889-025-25943-8. PMID- 41390355 OWN - NLM STAT- MEDLINE DCOM- 20260211 LR - 20260530 IS - 1867-0687 (Electronic) IS - 1708-8569 (Print) VI - 22 IP - 1 DP - 2026 Jan TI - Final height prediction of girls at menarche: a combined model using left hand and wrist bone age, knee radiomic scores, and clinical characteristics. PG - 129-141 LID - 10.1007/s12519-025-01002-5 [doi] AB - BACKGROUND: Accurate final height prediction for girls with menarche is important, yet traditional Greulich-Pyle (GP) and Bayley-Pinneau predictions based on left hand-wrist bone age (BA) and target height demonstrate limited accuracy. This study aims to develop a method to more accurately predict final height. METHODS: One hundred and seventy-three girls with menarche from August 2018 to June 2023 were analyzed retrospectively. BAs in Greulich and Pyle and Hoerr knee atlases were evaluated. Knee radiomic features were extracted using PyRadiomics; least absolute shrinkage and selection operator regression was utilized to develop radiomic scores of the distal femur and proximal tibia. Ordinary least squares regression with stepwise selection was used to build a multilinear equation. This was further compared with traditional methods in fivefold cross-validation (CV = 5) using residual distribution and Bland-Altman agreement analysis. RESULTS: Height gain in our Chinese cohort after menarche was 8.94 +/- 2.99 cm. A stepwise multilinear equation was built with height at menarche, BA of GP and radiomic score of the distal femur (R(2) = 0.733, F statistic = 115.1, P < 0.05). Compared with traditional methods, a multilinear equation displayed the lowest residuals (residual range: - 5.677 cm to + 6.444 cm) and best Bland-Altman agreement (the mean difference: - 0.01 cm, 95% limits of agreement: - 3.96 to + 3.93 cm). CONCLUSIONS: A robust linear regression model that incorporates knee radiomic scores, BA of GP, height at menarche, and father's height demonstrated the best final height prediction in our cohort. This research is an innovative application of radiomic score of the distal femur to final height prediction. Further validation is warranted to test robustness across populations and scenarios. CI - (c) 2025. The Author(s). FAU - Xu, Xue-Qiong AU - Xu XQ AD - Department of Endocrinology, Genetics and Metabolism, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. FAU - Chen, Yao AU - Chen Y AD - Department of Endocrinology, Genetics and Metabolism, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. FAU - Wang, Yi-Rou AU - Wang YR AD - Department of Endocrinology, Genetics and Metabolism, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. FAU - Hu, Fei-Han AU - Hu FH AD - Department of Endocrinology, Genetics and Metabolism, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. FAU - Li, Juan AU - Li J AD - Department of Endocrinology, Genetics and Metabolism, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. FAU - Chang, Guo-Ying AU - Chang GY AD - Department of Endocrinology, Genetics and Metabolism, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. FAU - Li, Xin AU - Li X AD - Department of Endocrinology, Genetics and Metabolism, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. FAU - Wang, Rui AU - Wang R AD - Department of Cardiology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. FAU - Ding, Yu AU - Ding Y AD - Department of Endocrinology, Genetics and Metabolism, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. dingyu@scmc.com.cn. FAU - Wang, Xiu-Min AU - Wang XM AUID- ORCID: 0000-0002-2186-759X AD - Department of Endocrinology, Genetics and Metabolism, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. wangxiumin1019@126.com. LA - eng GR - QNWS2024011/Shanghai Oriental Talents Program/ GR - YG2023QNA35/The Fundamental Research Funds for the Central Universities/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251213 PL - Switzerland TA - World J Pediatr JT - World journal of pediatrics : WJP JID - 101278599 SB - IM MH - Humans MH - Female MH - *Menarche/physiology MH - Retrospective Studies MH - *Body Height MH - Child MH - *Age Determination by Skeleton/methods MH - *Knee/diagnostic imaging MH - Wrist/diagnostic imaging MH - Adolescent MH - *Hand Bones/diagnostic imaging MH - China MH - Radiomics PMC - PMC12894113 OTO - NOTNLM OT - Bone age OT - Final height OT - Knee OT - Menarche OT - Radiomic scores COIS- Declarations. Conflict of interest: No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article. Authors Yao Chen and Guo-Ying Chang are members of the Youth Editorial Board Member for World Journal of Pediatrics. The paper was handled by the other Editor and has undergone rigorous peer review process. Authors Yao Chen and Guo-Ying Chang were excluded from all editorial decisions related to this manuscript. Ethical approval: The study protocol was approved by the Institutional Ethics Committee of Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China (approval number: SCMCIRB-K2025024-1). The ethics committee granted written consent waiver as this retrospective study used de-identified clinical cases obtained during prior diagnostic/therapeutic procedures. EDAT- 2025/12/14 00:39 MHDA- 2026/02/12 00:47 PMCR- 2025/12/13 CRDT- 2025/12/13 23:06 PHST- 2025/06/03 00:00 [received] PHST- 2025/11/17 00:00 [accepted] PHST- 2025/07/21 00:00 [revised] PHST- 2026/02/12 00:47 [medline] PHST- 2025/12/14 00:39 [pubmed] PHST- 2025/12/13 23:06 [entrez] PHST- 2025/12/13 00:00 [pmc-release] AID - 10.1007/s12519-025-01002-5 [pii] AID - 1002 [pii] AID - 10.1007/s12519-025-01002-5 [doi] PST - ppublish SO - World J Pediatr. 2026 Jan;22(1):129-141. doi: 10.1007/s12519-025-01002-5. Epub 2025 Dec 13. PMID- 41389999 OWN - NLM STAT- MEDLINE DCOM- 20260111 LR - 20260111 IS - 1872-8227 (Electronic) IS - 0168-8227 (Linking) VI - 231 DP - 2026 Jan TI - Prevalence of metabolic syndrome among adolescents in Cape Town, South Africa: a cross-sectional analysis comparing five diagnostic criteria to explore suitability. PG - 113053 LID - S0168-8227(25)01068-X [pii] LID - 10.1016/j.diabres.2025.113053 [doi] AB - BACKGROUND: Metabolic syndrome (MetS) among adolescents is a growing public health concern globally, yet data from sub-Saharan Africa remain scarce. Variability in diagnostic criteria further complicates surveillance efforts. This study aimed to estimate the prevalence of MetS among adolescents in Cape Town, South Africa, using five diagnostic criteria, to assess the agreement between definitions and explore criteria suitability. METHODS: We conducted a cross-sectional study among 489 adolescents aged 13-18 years, sampled from coeducational public high schools in Cape Town's Metro South district. Anthropometric, blood pressure, and fasting biochemical measurements were collected. MetS prevalence was assessed using the Cook, Ford, de Ferranti, International Diabetes Federation (IDF), and Agudelo criteria. Agreement between definitions was evaluated using unweighted Kappa statistics. RESULTS: The MetS prevalence with four criteria were similar, ranging from 4.7 % (IDF) to 5.7 % (Ford), while one criterion differed significantly with 17.8 % (de Ferranti). Central obesity and raised blood pressure were the most prevalent MetS components across criteria. Females exhibited higher MetS prevalence than males across the five criteria. Very good agreement was observed between Cook, Ford, and Agudelo definitions (kappa > 0.85), while agreement involving IDF and de Ferranti definitions was fair to moderate (kappa = 0.33-0.42). CONCLUSIONS: Our results underscore the need for locally validated, population-specific MetS criteria and diagnostic thresholds to support early identification of adolescents at risk of cardiometabolic disease (CMD). In the absence of such criteria, the Cook and Ford definitions appear particularly suitable for identifying MetS among South African adolescents, while the Agudelo definition is appropriate when waist circumference (WC) measures are unavailable. Finally, our findings reveal a concerning CMD risk profile among adolescents in Cape Town, South Africa, with a particularly high burden observed in females. CI - Copyright (c) 2025 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Wentzel, Annalie AU - Wentzel A AD - School of Public Health, University of the Western Cape, Bellville 7535, South Africa; Non-Communicable Diseases Research Unit, South African Medical Research Council, Tygerberg 7505, South Africa. Electronic address: 3814491@myuwc.ac.za. FAU - Nguyen, Kim Anh AU - Nguyen KA AD - Non-Communicable Diseases Research Unit, South African Medical Research Council, Tygerberg 7505, South Africa. FAU - von Philipsborn, Peter AU - von Philipsborn P AD - Chair of Public Health Nutrition, University of Bayreuth, Bayreuth, Germany; Pettenkofer School of Public Health, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Levitt, Naomi AU - Levitt N AD - Chronic Disease Initiative for Africa, Department of Medicine, University of Cape Town, Rondebosch 7700, South Africa. FAU - Mchiza, Zandile J R AU - Mchiza ZJR AD - School of Public Health, University of the Western Cape, Bellville 7535, South Africa; Non-Communicable Diseases Research Unit, South African Medical Research Council, Tygerberg 7505, South Africa. LA - eng PT - Comparative Study PT - Journal Article DEP - 20251211 PL - Ireland TA - Diabetes Res Clin Pract JT - Diabetes research and clinical practice JID - 8508335 SB - IM MH - Humans MH - *Metabolic Syndrome/epidemiology/diagnosis MH - Adolescent MH - South Africa/epidemiology MH - Female MH - Cross-Sectional Studies MH - Male MH - Prevalence OTO - NOTNLM OT - Adolescents OT - Cardiometabolic Risk OT - Diagnostic Criteria OT - Metabolic Syndrome OT - South Africa COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/12/14 00:39 MHDA- 2026/01/12 00:37 CRDT- 2025/12/13 19:35 PHST- 2025/08/05 00:00 [received] PHST- 2025/12/01 00:00 [revised] PHST- 2025/12/10 00:00 [accepted] PHST- 2026/01/12 00:37 [medline] PHST- 2025/12/14 00:39 [pubmed] PHST- 2025/12/13 19:35 [entrez] AID - S0168-8227(25)01068-X [pii] AID - 10.1016/j.diabres.2025.113053 [doi] PST - ppublish SO - Diabetes Res Clin Pract. 2026 Jan;231:113053. doi: 10.1016/j.diabres.2025.113053. Epub 2025 Dec 11. PMID- 41389132 OWN - NLM STAT- MEDLINE DCOM- 20260922 LR - 20261008 IS - 1432-1971 (Electronic) IS - 0172-0643 (Linking) VI - 47 IP - 7 DP - 2026 Oct TI - Enhancing Cardiopulmonary Exercise Testing in Complex Congenital Heart Disease: The Role of Spirometry, Body Composition, and Handgrip Strength. PG - 2796-2807 LID - 10.1007/s00246-025-04134-7 [doi] AB - Cardiopulmonary exercise testing (CPET) is a cornerstone of functional assessment in congenital heart disease (CHD), yet there are additional important contributors to exercise limitation that are not directly measured by CPET. This narrative review highlights the complementary utility of spirometry, body composition analysis, and evaluation of handgrip strength in augmenting our understanding of functional capacity in CHD. Spirometry provides insights into restrictive lung disease patterns prevalent in post-surgical CHD populations; body composition analysis, especially lean mass assessment, can reveal sarcopenia not apparent using BMI alone; and handgrip strength serves as a validated surrogate for overall muscular function and frailty. We propose routine integration of all three testing techniques as complements to CPET protocols to enhance clinical assessment, guide rehabilitation, and support prognostication in pediatric CHD patients. This review advocates for broader adoption and standardization of these measures in clinical settings to improve risk stratification and long-term outcomes. CI - (c) 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Wang, Alan P AU - Wang AP AD - Division of Pediatric Cardiology, Mayo Clinic, 200 1 st Street SW, Rochester, MN, 55905, USA. Wang.alan@mayo.edu. FAU - Garcia, Clara AU - Garcia C AD - Division of Pediatric Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E. Chicago Avenue, Chicago, IL, 60611, USA. FAU - Schellenberg, Dylan AU - Schellenberg D AD - Division of Pediatric Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E. Chicago Avenue, Chicago, IL, 60611, USA. FAU - Griffith, Garett J AU - Griffith GJ AD - Northwestern University Department of Physical Therapy and Human Movement Sciences, 645 N. Michigan Ave., Suite 1100, Chicago, 60611, USA. FAU - Ward, Kendra AU - Ward K AD - Division of Pediatric Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E. Chicago Avenue, Chicago, IL, 60611, USA. LA - eng PT - Journal Article PT - Review DEP - 20251213 PL - United States TA - Pediatr Cardiol JT - Pediatric cardiology JID - 8003849 SB - IM MH - Humans MH - *Hand Strength MH - *Spirometry MH - *Heart Defects, Congenital/physiopathology/diagnosis MH - *Body Composition MH - *Exercise Test/methods MH - Exercise Tolerance MH - Child OTO - NOTNLM OT - Bioelectrical impedance analysis OT - Body composition analysis OT - Cardiopulmonary exercise testing OT - Dual-energy x-ray absorptiometry OT - Exercise capacity OT - Handgrip strength OT - Pediatric OT - Spirometry COIS- Declarations. Conflict of interest: The authors declare no competing interests. EDAT- 2025/12/13 13:00 MHDA- 2026/09/22 21:36 CRDT- 2025/12/13 11:12 PHST- 2025/09/26 00:00 [received] PHST- 2025/11/29 00:00 [accepted] PHST- 2026/09/22 21:36 [medline] PHST- 2025/12/13 13:00 [pubmed] PHST- 2025/12/13 11:12 [entrez] AID - 10.1007/s00246-025-04134-7 [pii] AID - 10.1007/s00246-025-04134-7 [doi] PST - ppublish SO - Pediatr Cardiol. 2026 Oct;47(7):2796-2807. doi: 10.1007/s00246-025-04134-7. Epub 2025 Dec 13. PMID- 41388322 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260211 LR - 20260212 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 14 IP - 1 DP - 2025 Dec 13 TI - Food addiction in children: a network analysis of nutritional, metabolic, and sociodemographic factors. PG - 47 LID - 10.1186/s40337-025-01495-5 [doi] LID - 47 AB - BACKGROUND: Food addiction (FA) is a condition in which ultra-processed foods (UPFs) activate the brain's reward pathways, leading to binge eating, loss of control, and continued consumption despite negative consequences. It can appear early in childhood and is linked to behavioral, sociodemographic, and metabolic factors. This study assessed the contribution of FA, its structure, and connectivity in relation to sociodemographic, nutritional status, and metabolic variables in network analysis. METHODS: A cross-sectional study was conducted with 93 children (7-11 years old) living in Vitoria de Santo Antao, Brazil. FA was assessed using the Yale Food Addiction Scale for Children, which was translated and validated for the Brazilian child population. Sociodemographic (age, sex, race, socioeconomic class), anthropometric (body weight, height, waist circumference, BMI, BMI-for-age, body fat percentage, lean mass, and fat mass), and metabolic (blood pressure, total cholesterol, triglycerides, HDL, LDL, and fasting glucose) factors were analyzed. For network analysis, the degree centrality (DC), closeness centrality (CC), betweenness centrality (BC), and eigenvector centrality (EC) were evaluated. RESULTS: FA exhibited moderate centrality in sociodemographic and metabolic networks, acting as a connector between key variables such as age and socioeconomic class (BC = 0.071-0.500; EC = 0.301-0.500; CC = 0.636-0.667). These metrics indicate that FA, while not dominant, maintains access to influential nodes and participates in relevant information pathways. In contrast, within the anthropometric network, FA showed a peripheral role, with fewer direct links (DC = 0.222-0.285) and limited intermediation (BC = 0.111). CONCLUSION: Variation in centrality across domains underscores the selective integration of FA, suggesting that its impact is context dependent. CI - (c) 2026. The Author(s). FAU - Carvalho Jurema Santos, Gabriela AU - Carvalho Jurema Santos G AD - Federal University of Pernambuco, Academic Center of Vitoria, Vitoria de Santo Antao, Brazil. gabriela.cjsantos@ufpe.br. FAU - Goes Pacheco, Andre Luiz AU - Goes Pacheco AL AD - Federal University of Pernambuco, Academic Center of Vitoria, Vitoria de Santo Antao, Brazil. FAU - Almeida Oliveira, Tafnes AU - Almeida Oliveira T AD - Federal University of Pernambuco, Academic Center of Vitoria, Vitoria de Santo Antao, Brazil. FAU - Ribeiro Nogueira, Isabella AU - Ribeiro Nogueira I AD - Federal University of Pernambuco, Academic Center of Vitoria, Vitoria de Santo Antao, Brazil. FAU - Costa, Jonathan Manoel AU - Costa JM AD - Federal University of Pernambuco, Academic Center of Vitoria, Vitoria de Santo Antao, Brazil. FAU - Nobre, Isabele Goes AU - Nobre IG AD - Federal University of Pernambuco, Academic Center of Vitoria, Vitoria de Santo Antao, Brazil. FAU - Canuto, Raquel AU - Canuto R AD - Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. FAU - Leandro, Carol Gois AU - Leandro CG AD - Federal University of Pernambuco, Academic Center of Vitoria, Vitoria de Santo Antao, Brazil. carol.leandro@ufpe.br. LA - eng GR - 316405/2025-6/National Council for Scientific and Technological Development/ GR - 0233-4.05/25/Fundacao de Amparo a Ciencia e Tecnologia do Estado de Pernambuco/ GR - 1440-4.05/24/Fundacao de Amparo a Ciencia e Tecnologia do Estado de Pernambuco/ GR - 312079/2021-4/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/ GR - 797-20/Coordination for the Improvement of Higher Level or Education Personnel/ PT - Journal Article DEP - 20251213 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC12888354 OAB - Food addiction involves the uncontrolled and impulsive consumption of ultra-processed foods and can occur in childhood. Several factors may be associated with this condition; therefore, this study evaluates the contribution of food addiction within a network analysis framework including sociodemographic, nutritional, and metabolic variables. This study was conducted in Vitoria de Santo Antao, Brazil, with children aged 7 to 11 years. Three networks were constructed to analyze the association between food addiction and sociodemographic, anthropometric, and metabolic factors. Food addiction played a moderate role in the sociodemographic and metabolic networks, acting as a link between factors such as age and socioeconomic status. In contrast, in the anthropometric network, it had little influence, appearing more isolated and showing few direct connections with other variables. OABL- eng OTO - NOTNLM OT - Addictive behavior OT - Children OT - Complex network OT - Food consumption OT - High-order complex network OT - Nutritional status COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Research Ethics Committee of the Federal University of Pernambuco (number: 38865920.6.0000.5208). An informed consent form was given to parents and children before the assessments, and the principles of the Declaration of Helsinki were followed. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/13 06:29 MHDA- 2025/12/13 06:30 PMCR- 2025/12/13 CRDT- 2025/12/13 00:40 PHST- 2025/08/23 00:00 [received] PHST- 2025/12/01 00:00 [accepted] PHST- 2025/12/13 06:30 [medline] PHST- 2025/12/13 06:29 [pubmed] PHST- 2025/12/13 00:40 [entrez] PHST- 2025/12/13 00:00 [pmc-release] AID - 10.1186/s40337-025-01495-5 [pii] AID - 1495 [pii] AID - 10.1186/s40337-025-01495-5 [doi] PST - epublish SO - J Eat Disord. 2025 Dec 13;14(1):47. doi: 10.1186/s40337-025-01495-5. PMID- 41387802 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260627 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2025 Dec 13 TI - A systematic review of methodological approaches and measurement of adherence to micronutrient supplementation among women of reproductive age in low- and middle-income countries. PG - 313 LID - 10.1186/s12889-025-24944-x [doi] LID - 313 AB - BACKGROUND: Ensuring adherence to recommended micronutrient supplementation regimens is essential for addressing malnutrition among women in low- and middle-income countries (LMICs). While efficacy trials often use biomarker changes as proxies for adherence, public health programs employ diverse methodologies to measure adherence. However, consolidated evidence on the methodological approaches used in these programs and the extent of their standardization remains scarce. This systematic review addresses this gap by exploring adherence measurement methodologies, including adherence thresholds, data collection methods, the number of methods utilized, and measurement frequencies. METHODS: We conducted a literature search on PubMed, Scopus, and Embase. Studies that measured adherence to WHO-recommended micronutrient supplements among women aged 15-49 in LMICs were included. Two reviewers screened titles/abstracts and full texts independently. Fifty-nine articles met the criteria. Data extraction involved four researchers. Article quality was assessed using Cochrane tools. RESULTS: We categorized the included studies into behavioral vs. non-behavioral interventions to identify unique patterns between the two. Across non-behavioral studies, adherence was frequently defined with a threshold of 80%. These studies commonly used pill count to measure adherence and conducted frequent monitoring. Behavioral studies often adopted more diverse thresholds (e.g., 70%, 90 tablets), while 67% of them did not provide a clear threshold to define adherence. Self-report was the most commonly used measurement approach. The use of data triangulation and regular monitoring bolstered the validity of self-reports. CONCLUSIONS: Micronutrient supplementation programs would benefit from adopting evidence-based thresholds to define adherence levels, enhancing comparability across studies. Using a combination of methods and cross-checking data from multiple sources can improve the validity of adherence measurements. We recommend against treating adherence as a static, standalone construct; instead, reporting its trajectory throughout an intervention and its association with health outcomes can provide valuable insights for program planning. In terms of study characteristics, most studies have primarily focused on pregnant and lactating women, leaving adherence measurement approaches among nonpregnant women and adolescents largely understudied. We strongly encourage future research to investigate how methodological issues of adherence is uniquely experienced among this underserved population. FAU - Kang, Bee-Ah AU - Kang BA AD - Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD, 21215, USA. beeah.kang@jhu.edu. FAU - Britton, Jordyn AU - Britton J AD - Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St, Baltimore, MD, 21215, USA. AD - Howard University College of Medicine, 2400 6th St NW, Washington, DC, 20059, USA. FAU - Olarewaju, Olajumoke Kiito AU - Olarewaju OK AD - Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD, 21215, USA. FAU - Luitel, Aditi AU - Luitel A AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St, Baltimore, MD, 21215, USA. AD - Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, 10461, USA. FAU - Stephens, Daryl AU - Stephens D AD - Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD, 21215, USA. FAU - Rimal, Rajiv N AU - Rimal RN AD - Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD, 21215, USA. LA - eng GR - INV-035431/GATES/Gates Foundation/United States PT - Journal Article PT - Systematic Review DEP - 20251213 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - 0 (Micronutrients) SB - IM MH - Humans MH - Female MH - *Dietary Supplements/statistics & numerical data MH - *Micronutrients/administration & dosage MH - *Developing Countries MH - Adolescent MH - Adult MH - *Patient Compliance/statistics & numerical data MH - Middle Aged MH - Young Adult PMC - PMC12836925 OTO - NOTNLM OT - Adherence OT - Compliance OT - Maternal nutrition OT - Micronutrient OT - Micronutrient supplementation OT - Nutritional behavior OT - Women of reproductive age COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/13 00:32 MHDA- 2026/06/27 06:45 PMCR- 2025/12/13 CRDT- 2025/12/12 23:35 PHST- 2024/12/31 00:00 [received] PHST- 2025/09/16 00:00 [accepted] PHST- 2026/06/27 06:45 [medline] PHST- 2025/12/13 00:32 [pubmed] PHST- 2025/12/12 23:35 [entrez] PHST- 2025/12/13 00:00 [pmc-release] AID - 10.1186/s12889-025-24944-x [pii] AID - 24944 [pii] AID - 10.1186/s12889-025-24944-x [doi] PST - epublish SO - BMC Public Health. 2025 Dec 13;26(1):313. doi: 10.1186/s12889-025-24944-x. PMID- 41386059 OWN - NLM STAT- MEDLINE DCOM- 20260124 LR - 20260127 IS - 1090-2414 (Electronic) IS - 0147-6513 (Linking) VI - 309 DP - 2026 Jan 1 TI - Fluoride exposure disrupts creatinine homeostasis and undermines the reliability of urinary metabolomics normalization. PG - 119555 LID - S0147-6513(25)01900-1 [pii] LID - 10.1016/j.ecoenv.2025.119555 [doi] AB - Urinary creatinine is widely used to adjust for dilution in studies of urinary biomarkers and metabolomics, yet its stability under environmental exposures is insufficiently evaluated. We analyzed data from U.S. adolescents (NHANES, n = 2378) and a cross-sectional sample of older Chinese adults (n = 475) to assess whether fluoride exposure disrupts urinary creatinine homeostasis and compromises its effectiveness as a normalization factor. In NHANES, participants with missing urinary fluoride measurements, abnormal urine albumin-to-creatinine ratios, or extreme fluoride values were excluded. In both populations, urinary fluoride demonstrated a nonlinear inverted L-shaped association with creatinine, characterized by a steep increase at lower exposure levels followed by a plateau. To quantify the downstream implications for metabolomic analyses, we compared results from unadjusted data with three dilution-control strategies: creatinine adjustment, specific gravity adjustment, and osmolality adjustment. Creatinine normalization markedly altered metabolite identification and pathway enrichment outcomes: 47.34 % of differential metabolites reversed their expression direction, and 24.72 % changed statistical significance. Enriched pathways shifted as well-from amino acid metabolism and circadian rhythm in the unadjusted analysis to lysine degradation and pyrimidine metabolism after creatinine adjustment. In contrast, specific gravity- and osmolality-based normalization produced results highly concordant with the unadjusted data in both metabolite directionality and pathway structure. Together, these findings indicate that fluoride exposure perturbs creatinine homeostasis and, consequently, the use of creatinine as a normalization factor can introduce substantial bias in urinary metabolomics. Caution is therefore warranted when applying creatinine adjustment in environmental epidemiology, particularly in populations with fluoride exposure. CI - Copyright (c) 2025 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Li, Ailin AU - Li A AD - Key Lab of Etiology and Epidemiology, Education Department of Heilongjiang Province & Ministry of Health (23618504), School of Public Health, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang Province 150081, China. FAU - Wu, Lei AU - Wu L AD - Key Lab of Etiology and Epidemiology, Education Department of Heilongjiang Province & Ministry of Health (23618504), School of Public Health, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang Province 150081, China. FAU - Zhang, Rui AU - Zhang R AD - Key Lab of Etiology and Epidemiology, Education Department of Heilongjiang Province & Ministry of Health (23618504), School of Public Health, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang Province 150081, China. FAU - Yan, Shirui AU - Yan S AD - Key Lab of Etiology and Epidemiology, Education Department of Heilongjiang Province & Ministry of Health (23618504), School of Public Health, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang Province 150081, China. FAU - Mo, Zhe AU - Mo Z AD - Key Lab of Etiology and Epidemiology, Education Department of Heilongjiang Province & Ministry of Health (23618504), School of Public Health, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang Province 150081, China; Department of Environmental Health, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China. FAU - Wu, Di AU - Wu D AD - Key Lab of Etiology and Epidemiology, Education Department of Heilongjiang Province & Ministry of Health (23618504), School of Public Health, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang Province 150081, China. FAU - Li, Xinxiao AU - Li X AD - Key Lab of Etiology and Epidemiology, Education Department of Heilongjiang Province & Ministry of Health (23618504), School of Public Health, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang Province 150081, China. FAU - Wang, Xiaowei AU - Wang X AD - Key Lab of Etiology and Epidemiology, Education Department of Heilongjiang Province & Ministry of Health (23618504), School of Public Health, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang Province 150081, China. FAU - Luo, Minghan AU - Luo M AD - Key Lab of Etiology and Epidemiology, Education Department of Heilongjiang Province & Ministry of Health (23618504), School of Public Health, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang Province 150081, China. FAU - Gao, Nian AU - Gao N AD - Key Lab of Etiology and Epidemiology, Education Department of Heilongjiang Province & Ministry of Health (23618504), School of Public Health, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang Province 150081, China. FAU - Zafar, Gazala AU - Zafar G AD - Key Lab of Etiology and Epidemiology, Education Department of Heilongjiang Province & Ministry of Health (23618504), School of Public Health, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang Province 150081, China. FAU - Pei, Junrui AU - Pei J AD - Key Lab of Etiology and Epidemiology, Education Department of Heilongjiang Province & Ministry of Health (23618504), School of Public Health, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang Province 150081, China; Qiqihar Medical University, Qiqihar, Heilongjiang Province 161003, China. Electronic address: pjr2003@126.com. LA - eng PT - Journal Article DEP - 20251211 PL - Netherlands TA - Ecotoxicol Environ Saf JT - Ecotoxicology and environmental safety JID - 7805381 RN - AYI8EX34EU (Creatinine) RN - Q80VPU408O (Fluorides) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Creatinine/urine MH - *Metabolomics MH - Male MH - Female MH - *Fluorides/urine/toxicity MH - Homeostasis/drug effects MH - Adolescent MH - Cross-Sectional Studies MH - Biomarkers/urine MH - *Environmental Exposure MH - Adult MH - Middle Aged MH - Aged MH - Nutrition Surveys MH - Young Adult MH - Reproducibility of Results OTO - NOTNLM OT - Creatinine OT - Enrichment analysis OT - Fluoride OT - Metabolomics OT - Urine normalization COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/12/13 00:32 MHDA- 2026/01/24 06:35 CRDT- 2025/12/12 18:22 PHST- 2025/07/25 00:00 [received] PHST- 2025/11/18 00:00 [revised] PHST- 2025/12/09 00:00 [accepted] PHST- 2026/01/24 06:35 [medline] PHST- 2025/12/13 00:32 [pubmed] PHST- 2025/12/12 18:22 [entrez] AID - S0147-6513(25)01900-1 [pii] AID - 10.1016/j.ecoenv.2025.119555 [doi] PST - ppublish SO - Ecotoxicol Environ Saf. 2026 Jan 1;309:119555. doi: 10.1016/j.ecoenv.2025.119555. Epub 2025 Dec 11. PMID- 41385787 OWN - NLM STAT- MEDLINE DCOM- 20251212 LR - 20251231 IS - 1438-8871 (Electronic) IS - 1439-4456 (Print) IS - 1438-8871 (Linking) VI - 27 DP - 2025 Dec 12 TI - Lumbar Acceleration Gait Estimation: "Step-by-Step" Algorithm Updates and Improvements. PG - e72831 LID - 10.2196/72831 [doi] LID - e72831 AB - BACKGROUND: Digital health technologies, such as accelerometry, offer low participant burden and provide quantitative metrics with ease of deployment, making them increasingly popular for gait monitoring. Remote gait monitoring delivers quantifiable, continuous health measures over extended periods, surpassing the limited insights from single clinic or laboratory visits and offering a more comprehensive health perspective. Numerous gait algorithm implementations, inspired by prior research, aim to standardize these metrics across devices. The SciKit Digital Health (SKDH) package exemplifies this as a device-agnostic framework. OBJECTIVE: This study introduces a series of literature-informed enhancements to the SKDH gait algorithm, improving its performance against reference standards and reducing the need for manual parameter adjustments across diverse populations. METHODS: A block-wise refinement process was undertaken, examining each algorithmic component for potential enhancements and evaluating their cumulative impact on the complete gait algorithm and the metrics generated. RESULTS: Using data from healthy adult and pediatric participants, the novel gait event estimation method reduced the mean absolute error by more than 50% compared with its predecessor. Following the updates, the intraclass correlation values for final gait metric concordance with the in-laboratory reference improved markedly, from 0.50-0.74 to 0.81-0.90. Additionally, the systematic bias observed in the previous version's gait speed estimation was rectified, narrowing the difference from the reference from 0.065-0.230 to 0.00-0.03 m/s. CONCLUSIONS: The findings from this study provide robust evidence supporting the validity of the enhancements made to the gait algorithm. They demonstrate that a single lumbar accelerometer can capture gait characteristics with high accuracy and reliability across various speeds and age groups. CI - (c)Lukas Adamowicz, Wenyi Lin, F Isik Karahanoglu, Xuemei Cai, Mar Santamaria, Charmaine Demanuele, Junrui Di. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 12.12.2025. FAU - Adamowicz, Lukas AU - Adamowicz L AUID- ORCID: 0000-0001-6992-9545 AD - AI/ML Quantitative Digital Sciences, Pfizer Research and Development, Pfizer, Cambridge, MA, United States. FAU - Lin, Wenyi AU - Lin W AUID- ORCID: 0000-0001-8767-1795 AD - AI/ML Quantitative Digital Sciences, Pfizer Research and Development, Pfizer, Cambridge, MA, United States. FAU - Karahanoglu, F Isik AU - Karahanoglu FI AUID- ORCID: 0000-0002-9162-8367 AD - AI/ML Quantitative Digital Sciences, Pfizer Research and Development, Pfizer, Cambridge, MA, United States. FAU - Cai, Xuemei AU - Cai X AUID- ORCID: 0000-0001-9822-9935 AD - Biomeasures, Endpoints, and Study Technologies, Pfizer Research and Development, Pfizer, Cambridge, MA, United States. FAU - Santamaria, Mar AU - Santamaria M AUID- ORCID: 0009-0009-7770-9425 AD - Biomeasures, Endpoints, and Study Technologies, Pfizer Research and Development, Pfizer, Cambridge, MA, United States. FAU - Demanuele, Charmaine AU - Demanuele C AUID- ORCID: 0000-0002-7715-9920 AD - AI/ML Quantitative Digital Sciences, Pfizer Research and Development, Pfizer, Cambridge, MA, United States. FAU - Di, Junrui AU - Di J AUID- ORCID: 0000-0001-6325-8090 AD - AI/ML Quantitative Digital Sciences, Pfizer Research and Development, Pfizer, Cambridge, MA, United States. LA - eng PT - Journal Article DEP - 20251212 PL - Canada TA - J Med Internet Res JT - Journal of medical Internet research JID - 100959882 SB - IM MH - Humans MH - *Algorithms MH - *Gait/physiology MH - Adult MH - *Accelerometry MH - Child MH - Male MH - Female MH - *Gait Analysis/methods MH - Young Adult MH - *Lumbosacral Region/physiology MH - Acceleration PMC - PMC12743242 OTO - NOTNLM OT - IMU OT - accelerometer OT - gait OT - walking OT - walking speed COIS- Conflicts of Interest: All authors were employees and shareholders of Pfizer, Inc during the conduct and writing of the paper. EDAT- 2025/12/12 19:28 MHDA- 2025/12/12 19:29 PMCR- 2025/12/12 CRDT- 2025/12/12 16:54 PHST- 2025/02/19 00:00 [received] PHST- 2025/11/07 00:00 [accepted] PHST- 2025/12/12 19:29 [medline] PHST- 2025/12/12 19:28 [pubmed] PHST- 2025/12/12 16:54 [entrez] PHST- 2025/12/12 00:00 [pmc-release] AID - v27i1e72831 [pii] AID - 10.2196/72831 [doi] PST - epublish SO - J Med Internet Res. 2025 Dec 12;27:e72831. doi: 10.2196/72831. PMID- 41384644 OWN - NLM STAT- MEDLINE DCOM- 20260307 LR - 20260920 IS - 1536-4801 (Electronic) IS - 0277-2116 (Print) IS - 0277-2116 (Linking) VI - 82 IP - 3 DP - 2026 Mar TI - Vibration-controlled transient elastography in pediatric metabolic dysfunction-associated steatotic liver disease. PG - 741-750 LID - 10.1002/jpn3.70284 [doi] AB - OBJECTIVES: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent disease in children. Vibration-controlled transient elastography (VCTE) offers a noninvasive alternative to liver biopsy, using controlled attenuation parameter (CAP) to estimate steatosis and liver stiffness measurement (LSM) for fibrosis. However, pediatric data with histological validation are limited. This prospective, multicenter study evaluated the accuracy of CAP and LSM in pediatric MASLD. METHODS: Children with histologically confirmed MASLD from the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Database 3 underwent VCTE within 6 months of liver biopsy. CAP was evaluated for correlation with steatosis grades, and LSM for correlation with fibrosis stages. The diagnostic performance of LSM in distinguishing fibrosis stages was analyzed using histological findings as the reference standard. RESULTS: Among 92 children with MASLD (mean age 13 +/- 3 years), CAP values were similar across steatosis grades (median 325, 310, and 323 dB/m for grades 1-3, respectively) and showed no significant correlation with histologic steatosis (p = 0.422). Median LSM values increased with fibrosis stage (6.0-8.8 kPa), but significant differences were detected only between stage 0 and stage 3 fibrosis (p = 0.037). For advanced fibrosis (stages 3-4), area under the receiver operating characteristic curve was 0.67, with sensitivity 67%, specificity 76%, positive predictive value 40%, and negative predictive value 90%. CONCLUSION: In this prospective, multicenter cohort, VCTE showed modest accuracy for grading steatosis or staging fibrosis in pediatric MASLD. Improved noninvasive methods are urgently needed for evaluation and monitoring in this population. CI - (c) 2025 The Author(s). Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Nichols, Lauren B AU - Nichols LB AUID- ORCID: 0009-0000-6937-0550 AD - Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California San Diego School of Medicine, La Jolla, California, USA. AD - Department of Gastroenterology, Rady Children's Hospital, San Diego, California, USA. FAU - Oakes, Sebastian G J AU - Oakes SGJ AUID- ORCID: 0009-0004-0613-7881 AD - Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California San Diego School of Medicine, La Jolla, California, USA. AD - Earl Warren College, University of California San Diego, La Jolla, California, USA. FAU - Behling, Cynthia AU - Behling C AUID- ORCID: 0000-0001-7016-2636 AD - Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California San Diego School of Medicine, La Jolla, California, USA. FAU - Adams, Kathryn Harlow AU - Adams KH AUID- ORCID: 0000-0003-1478-5235 AD - Department of Pediatrics, Riley Children's Hospital, Indianapolis, Indiana, USA. FAU - Fishbein, Mark H AU - Fishbein MH AUID- ORCID: 0000-0002-3597-3748 AD - Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA. FAU - Hertel, Paula AU - Hertel P AUID- ORCID: 0000-0002-2314-7297 AD - Department of Pediatrics, Texas Children's Hospital, Houston, Texas, USA. FAU - Jarasvaraparn, Chao AU - Jarasvaraparn C AUID- ORCID: 0000-0001-8076-9378 AD - Department of Pediatrics, Riley Children's Hospital, Indianapolis, Indiana, USA. FAU - Molleston, Jean P AU - Molleston JP AUID- ORCID: 0000-0002-8708-0298 AD - Department of Pediatrics, Riley Children's Hospital, Indianapolis, Indiana, USA. FAU - Mouzaki, Marialena AU - Mouzaki M AUID- ORCID: 0000-0002-6186-2443 AD - Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. AD - College of Medicine University of Cincinnati, Cincinnati, Ohio, USA. FAU - Sirlin, Claude B AU - Sirlin CB AUID- ORCID: 0000-0002-6639-9072 AD - Radiology, UCSD, La Jolla, California, USA. FAU - Vos, Miriam B AU - Vos MB AUID- ORCID: 0000-0002-0817-7068 AD - Department of Pediatrics, Emory University, Atlanta, Georgia, USA. FAU - Wilson, Laura A AU - Wilson LA AUID- ORCID: 0000-0002-6294-4504 AD - Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA. FAU - Xanthakos, Stavra A AU - Xanthakos SA AUID- ORCID: 0000-0001-9179-005X AD - Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. AD - College of Medicine University of Cincinnati, Cincinnati, Ohio, USA. FAU - Schwimmer, Jeffrey B AU - Schwimmer JB AUID- ORCID: 0000-0001-8538-2877 AD - Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California San Diego School of Medicine, La Jolla, California, USA. AD - Department of Gastroenterology, Rady Children's Hospital, San Diego, California, USA. CN - NASH CRN LA - eng GR - U01DK061737/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/ GR - UL1TR000454/National Center for Advancing Translational Sciences (NCATS)/ GR - U01 DK061718/DK/NIDDK NIH HHS/United States GR - UL1 TR000006/TR/NCATS NIH HHS/United States GR - U01DK061738/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/ GR - UL1TR000004/National Center for Advancing Translational Sciences (NCATS)/ GR - UL1 TR000454/TR/NCATS NIH HHS/United States GR - U01 DK061734/DK/NIDDK NIH HHS/United States GR - U24DK061730/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/ GR - UL1 TR000077/TR/NCATS NIH HHS/United States GR - UL1 TR000004/TR/NCATS NIH HHS/United States GR - U01 DK061737/DK/NIDDK NIH HHS/United States GR - U01 DK061713/DK/NIDDK NIH HHS/United States GR - U01DK061730/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/ GR - U01 DK061732/DK/NIDDK NIH HHS/United States GR - UL1 TR000150/TR/NCATS NIH HHS/United States GR - UL1TR000006/National Center for Advancing Translational Sciences (NCATS)/ GR - U01DK061734/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/ GR - Intramural Division of the National Cancer Institute (NCI)/ GR - U01 DK061730/DK/NIDDK NIH HHS/United States GR - U24 DK061730/DK/NIDDK NIH HHS/United States GR - U01 DK061728/DK/NIDDK NIH HHS/United States GR - U01DK061728/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/ GR - UL1TR000100/National Center for Advancing Translational Sciences (NCATS)/ GR - U01 DK061738/DK/NIDDK NIH HHS/United States GR - UL1TR000448/National Center for Advancing Translational Sciences (NCATS)/ GR - UL1 TR000448/TR/NCATS NIH HHS/United States GR - U01DK061713/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/ GR - U01DK061732/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/ GR - U01DK061718/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/ GR - UL1 TR000423/TR/NCATS NIH HHS/United States GR - UL1 TR000100/TR/NCATS NIH HHS/United States GR - UL1 TR002345/TR/NCATS NIH HHS/United States GR - UL1TR000423/National Center for Advancing Translational Sciences (NCATS)/ GR - UL1TR000150/National Center for Advancing Translational Sciences (NCATS)/ GR - UL1TR000077/National Center for Advancing Translational Sciences (NCATS)/ PT - Journal Article PT - Multicenter Study DEP - 20251212 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM MH - Humans MH - *Elasticity Imaging Techniques/methods MH - Male MH - Female MH - Adolescent MH - Child MH - Prospective Studies MH - Vibration MH - *Liver Cirrhosis/diagnostic imaging/pathology/diagnosis MH - *Non-alcoholic Fatty Liver Disease/diagnostic imaging/pathology MH - *Liver/pathology/diagnostic imaging MH - Severity of Illness Index MH - Sensitivity and Specificity MH - *Fatty Liver/diagnostic imaging/pathology MH - ROC Curve PMC - PMC12964508 MID - NIHMS2154640 OTO - NOTNLM OT - cirrhosis OT - diagnostic accuracy OT - noninvasive test OT - obesity OT - steatohepatitis COIS- Lauren B. Nichols, Sebastian G. J. Oakes, Cynthia Behling, Kathryn Harlow Adams, Mark H. Fishbein, Paula Hertel, Chao Jarasvaraparn, Marialena Mouzaki, Laura A. Wilson: No conflicts of interest to report. Jean Molleston: Research grants to Indiana University from Mirum, Abbvie, Albireo, Gillead. Claude Sirlin: Reports payment to institution for research grants from ACR, Bayer, Foundation of NIH, GE, Gilead, Pfizer, Philips, Siemens, V Foundation; payment to institution for lab service agreements with OrsoBio, Enanta, Gilead, ICON, Intercept, Nusirt, Shire, Synageva, Takeda; payment to institution for institutional consulting for BMS, Exact Sciences, IBM-Watson, Pfizer; Personal consulting for Altimmune, Ascelia Pharma, Blade, Boehringer, Epigenomics, Guerbet, Livivos, and Novo Nordisk; payment to self for royalties and/or honoraria from Medscape, Wolters Kluwer, and HealthProMatch; ownership of stock options in Livivos; unpaid advisory board position in Quantix Bio; executive position for Livivos (Chief Medical Officer, unsalaried position with stock options and stock) through June 28, 2023; Principal Scientific Advisor to Livivos (unsalaried position with stock options and stock) since June 28, 2023; payment to self for serving as a speaker for HealthProMatch; support for attending meetings and/or travel from Fundacion Santa Fe, Congreso Argentino de Diagnostico por Imagenes, Stanford, Jornada Paulista de Radiologia, Ascelia Pharma, RSNA, Sociedad Radiologica de Puerto Rico, Hospital Espanol Auxilio Mutuo de Puerto Rico, Paris MASH, and Liver Forum; member (no payment) of Data Safety Monitoring board for National Cancer Institute funded Early Detection Research Network; equipment loans to institution from Butterfly, GE, Siemens, and Mayo; provision of contrast material to institution from Bayer. Miriam Vos: Research grants to Emory from Target NASH, Quest, Labcorp, and Sonic Incytes Medical Corp. Consultant to Boehringer Ingelheim, Novo Nordisk, Eli Lilly, Intercept, Takeda, and Alberio. Has stock or stock options in Thiogenesis and Tern Pharmaceuticals. Stavra A. Xanthakos: Research grants to Cincinnati Children's from Target NASH. Jeffrey B. Schwimmer: Grant support to UC San Diego from Seraphina, Intercept. Consultant for Merck. EDAT- 2025/12/12 17:54 MHDA- 2026/03/07 18:38 PMCR- 2026/03/06 CRDT- 2025/12/12 08:23 PHST- 2025/10/23 00:00 [revised] PHST- 2025/06/10 00:00 [received] PHST- 2025/11/01 00:00 [accepted] PHST- 2026/03/07 18:38 [medline] PHST- 2025/12/12 17:54 [pubmed] PHST- 2025/12/12 08:23 [entrez] PHST- 2026/03/06 00:00 [pmc-release] AID - JPN370284 [pii] AID - 10.1002/jpn3.70284 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2026 Mar;82(3):741-750. doi: 10.1002/jpn3.70284. Epub 2025 Dec 12. PMID- 41383326 OWN - NLM STAT- MEDLINE DCOM- 20251212 LR - 20251214 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Trends in physical fitness among polish children and adolescents. PG - 1576822 LID - 10.3389/fpubh.2025.1576822 [doi] LID - 1576822 AB - BACKGROUND: Human health, with physical fitness as one of its key indicators, is characterized by a dynamic nature. Therefore, monitoring motor abilities and the factors that influence them becomes particularly important. Recent studies on physical fitness trends among children and adolescents indicate a declining tendency, with a noticeable decrease in physical performance. Maintaining an optimal level of physical fitness in young individuals requires support not only from parents. Hence, health promotion policies should focus on fostering health-related physical fitness from early childhood. The aim of the current study was to determine physical fitness trends among Polish children and adolescents participating in the nationwide program "Athletics for All!" (AFA). An attempt was made to answer the question of whether the implementation of programs promoting physical activity among youth (as exemplified by the AFA program) has an impact on improving physical fitness and body build indicators as its markers. METHODS: Physical fitness was assessed in a group of 54,049 young individuals, including 31,789 girls and 22,260 boys, over eight consecutive years of the AFA program's implementation. The assessment was conducted using the OSF test, developed specifically for the AFA program, which includes a 3x10 m shuttle run, standing broad jump, 1 kg medicine ball throw, and a 4-min run. Statistical analyses were performed separately for each gender, assuming a significance level of alpha = 0.05. It was verified whether there were significant differences in the means between the groups distinguished based on the year of the study. RESULTS: The study results indicate that the implementation of the AFA program promoting physical activity among Polish youth has a positive impact on the improvement of physical fitness and body build parameters. Statistically significant differences were found in the mean values of measurements taken over the course of eight consecutive years. The results of multiple comparisons between the mean values of all the analyzed variables in different years revealed significant differences in most of the comparisons. CONCLUSION: The level of physical fitness among participants of the AFA program remained relatively stable over nearly a decade, which, in an era dominated by a sedentary lifestyle among modern youth, confirms the validity of implementing physical activity promotion programs (including the AFA program). CI - Copyright (c) 2025 Baj-Korpak, Zaworski, Wochna, Chmara and Stelmach. FAU - Baj-Korpak, Joanna AU - Baj-Korpak J AD - Department of Health Sciences, John Paul II University in Biala Podlaska, Biala Podlaska, Poland. FAU - Zaworski, Kamil AU - Zaworski K AD - Department of Health Sciences, John Paul II University in Biala Podlaska, Biala Podlaska, Poland. FAU - Wochna, Marek AU - Wochna M AD - Polish Athletics Association, Warsaw, Poland. FAU - Chmara, Sebastian AU - Chmara S AD - Polish Athletics Association, Warsaw, Poland. FAU - Stelmach, Marian J AU - Stelmach MJ AD - Department of Health Sciences, John Paul II University in Biala Podlaska, Biala Podlaska, Poland. LA - eng PT - Journal Article DEP - 20251126 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Poland MH - *Physical Fitness/physiology MH - Female MH - Adolescent MH - Male MH - Child MH - Exercise MH - *Health Promotion PMC - PMC12689887 OTO - NOTNLM OT - Body Mass Index OT - OSF test OT - Ponderal Index OT - adolescents OT - children OT - gender OT - physical fitness OT - trends COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/12 07:20 MHDA- 2025/12/12 07:21 PMCR- 2025/11/26 CRDT- 2025/12/12 04:25 PHST- 2025/02/17 00:00 [received] PHST- 2025/10/21 00:00 [revised] PHST- 2025/11/07 00:00 [accepted] PHST- 2025/12/12 07:21 [medline] PHST- 2025/12/12 07:20 [pubmed] PHST- 2025/12/12 04:25 [entrez] PHST- 2025/11/26 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1576822 [doi] PST - epublish SO - Front Public Health. 2025 Nov 26;13:1576822. doi: 10.3389/fpubh.2025.1576822. eCollection 2025. PMID- 41380455 OWN - NLM STAT- MEDLINE DCOM- 20260102 LR - 20261021 IS - 1872-8243 (Electronic) IS - 1386-5056 (Linking) VI - 207 DP - 2026 Mar 1 TI - Disability pension during emerging adulthood: Insights from the young-HUNT study on psychological distress, chronic pain, and policy reform. PG - 106216 LID - S1386-5056(25)00433-2 [pii] LID - 10.1016/j.ijmedinf.2025.106216 [doi] AB - INTRODUCTION: Disability pension (DP) among young adults has steadily increased in Norway, with chronic pain and psychological distress among the main causes. This study examined the association between co-occurring psychological distress and chronic pain in adolescence and the risk of DP during emerging adulthood, before and after the Norwegian Labour and Welfare Administration (NAV) reform. Machine learning survival models were also developed to predict early DP and identify consistent risk factors across cohorts. METHODS: Data from two general population surveys in 1995-1997 (Young-HUNT1) and 2006-2008 (Young-HUNT3) were linked to public registry data for DP, with a mean follow-up of 12 years. These represent populations pre- and post-NAV reform, respectively. Crude and adjusted Cox proportional hazards models tested associations between chronic pain, psychological distress and their co-occurrence with early DP. Machine learning survival models were developed using common predictors across cohorts and validated temporally. SurvSHAP(t) and hazard ratios were used for explainable risk factor analysis. RESULTS: Co-occurring psychological distress and chronic pain were associated with increased early DP risk in Young-HUNT3 (HR = 2.25, [95 % CI 1.62 to 3.14]) but not in Young-HUNT1. Tree-based machine learning models showed strong predictive performance and generalizability over time, with ExtraSurvivalTrees achieving a validation c-index of 0.75 [95 % CI 0.74-0.76]. Consistent risk factors included low social integration, limited physical activity, and low parental education in both cohorts, while additional factors post-reform included low self-esteem, poor self-rated health, and negative school experiences. CONCLUSION: Adolescents with co-occurring psychological distress and chronic pain face an elevated risk of early DP. Early identification and support are crucial, as risk factors extend beyond medical conditions. Findings also suggest that NAV policy changes may have influenced DP receipt rates among young adults. CI - Copyright (c) 2025 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Gorosito, Martin A AU - Gorosito MA AD - Centre for Intelligent Musculoskeletal Health, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway; Artificial Intelligence lab, Faculty of Technology, Art and Design, Oslo Metropolitan University, Oslo, Norway. Electronic address: martingo@oslomet.no. FAU - Berg, Bjornar AU - Berg B AD - Centre for Intelligent Musculoskeletal Health, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway; Department of Rehabilitation Science and Health Technology, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway. FAU - Yazidi, Anis AU - Yazidi A AD - Centre for Intelligent Musculoskeletal Health, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway; Artificial Intelligence lab, Faculty of Technology, Art and Design, Oslo Metropolitan University, Oslo, Norway; Department of Informatics, University of Oslo, Oslo, Norway; Department of Plastic and Reconstructive Surgery, Oslo University Hospital, Oslo, Norway. FAU - Hermansen, Asmund AU - Hermansen A AD - Department of Social Work, Child Welfare and Social Policy, Faculty of Social Sciences, Oslo Metropolitan University, Oslo, Norway. FAU - Oiestad, Britt Elin AU - Oiestad BE AD - Centre for Intelligent Musculoskeletal Health, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway; Department of Rehabilitation Science and Health Technology, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway. FAU - Grotle, Margreth AU - Grotle M AD - Centre for Intelligent Musculoskeletal Health, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway; Department of Rehabilitation Science and Health Technology, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway. FAU - Richardsen, Kare Ronn AU - Richardsen KR AD - Centre for Intelligent Musculoskeletal Health, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway; Department of Rehabilitation Science and Health Technology, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway; Faculty of Health and Social Sciences, University of South-Eastern Norway, Oslo, Norway. FAU - Haugerud, Harek AU - Haugerud H AD - Centre for Intelligent Musculoskeletal Health, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway; Artificial Intelligence lab, Faculty of Technology, Art and Design, Oslo Metropolitan University, Oslo, Norway. LA - eng PT - Journal Article DEP - 20251204 PL - Ireland TA - Int J Med Inform JT - International journal of medical informatics JID - 9711057 SB - IM MH - Humans MH - *Chronic Pain/epidemiology/psychology MH - Female MH - Male MH - Norway/epidemiology MH - *Pensions/statistics & numerical data MH - Adolescent MH - *Persons with Disabilities/statistics & numerical data/psychology MH - Young Adult MH - *Psychological Distress MH - Risk Factors MH - *Stress, Psychological/epidemiology MH - Adult MH - Machine Learning OTO - NOTNLM OT - Chronic pain OT - Disability pension OT - Machine learning OT - Psychological distress OT - Survival analysis OT - Young adults COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/12/12 03:28 MHDA- 2026/01/03 00:30 CRDT- 2025/12/11 18:07 PHST- 2025/08/11 00:00 [received] PHST- 2025/10/30 00:00 [revised] PHST- 2025/12/02 00:00 [accepted] PHST- 2026/01/03 00:30 [medline] PHST- 2025/12/12 03:28 [pubmed] PHST- 2025/12/11 18:07 [entrez] AID - S1386-5056(25)00433-2 [pii] AID - 10.1016/j.ijmedinf.2025.106216 [doi] PST - ppublish SO - Int J Med Inform. 2026 Mar 1;207:106216. doi: 10.1016/j.ijmedinf.2025.106216. Epub 2025 Dec 4. PMID- 41379304 OWN - NLM STAT- MEDLINE DCOM- 20260406 LR - 20261010 IS - 1720-8386 (Electronic) IS - 0391-4097 (Linking) VI - 49 IP - 4 DP - 2026 Apr TI - Anti-Mullerian hormone in anorexia nervosa: a biomarker of nutritional status and reproductive phenotype. PG - 867-877 LID - 10.1007/s40618-025-02776-1 [doi] AB - PURPOSE: To investigate Anti-Mullerian Hormone (AMH) levels in women with anorexia nervosa (AN) compared to individuals with constitutional thinness (CT) and healthy controls, and to evaluate the association between AMH, body mass index (BMI), and weight recovery. METHODS: This monocentric cross-sectional study included 191 women with AN, 41 with CT, and 55 controls. A subgroup of 42 patients with AN was reassessed after weight recovery. Hormonal, metabolic, and psychological parameters were analyzed. AMH was measured using a validated electrochemiluminescence immunoassay. Comparisons and correlations were performed using nonparametric tests and Pearson coefficients. RESULTS: Mean AMH plasma level was higher in patients with AN (30.5 +/- 1.6 pmol/l) than in controls (23.3 +/- 2.5 pmol/l, p = 0.0252) and CT (21.4 +/- 2.7 pmol/l, p = 0.0088). AMH was positively correlated with BMI, leptin, FSH, and LH in the AN group, and inversely associated with disease duration. AMH was the lowest in extreme undernutrition state (BMI /= 40 kg/m(2)) were excluded. Nutrition scores (HALP, PNI, NRI, CONUT) and systemic immune-inflammation indices (SII, NLR, PLR) were calculated from laboratory data. For the comparisons of SII, PLR, NLR, PNI, HALP, NRI, and CONUT values between groups, age was adjusted for, and an ANCOVA test was performed. Results: Among the systemic immune-inflammation indices, SII and NLR were significantly higher in both the overweight and obesity groups. The CONUT score, a negative indicator of nutritional status, demonstrated positive correlations with SII, NLR, and PLR in the overweight group, and with PLR in the obesity group. Although PNI showed significant inverse correlations with SII, PLR, and NLR in both groups, the mean PNI values remained above 50, indicating overall normal nutritional status in the study population. HALP was inversely correlated with SII, PLR, and NLR in both groups. Conclusions: The HALP score appears to be the most reliable marker, as it reflects the inverse relationship between nutritional status and systemic immune-inflammation indices. FAU - Uzun, Hafize AU - Uzun H AUID- ORCID: 0000-0002-1347-8498 AD - Department of Medical Biochemistry, Faculty of Medicine, Istanbul Atlas University, 34403 Istanbul, Turkey. FAU - Fenercioglu, Aysen Kutan AU - Fenercioglu AK AUID- ORCID: 0000-0003-2965-6102 AD - Department of Family Medicine, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, 34098 Istanbul, Turkey. FAU - Senyigit, Abdulhalim AU - Senyigit A AD - Department of Internal Medicine, Faculty of Medicine, Istanbul Atlas University, 34403 Istanbul, Turkey. FAU - Can, Gunay AU - Can G AD - Department of Public Health, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, 34098 Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20251203 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Nutritional Status/immunology MH - Adult MH - *Body Mass Index MH - *Inflammation/immunology/blood MH - Female MH - Male MH - Middle Aged MH - Retrospective Studies MH - Young Adult MH - Adolescent MH - Biomarkers/blood MH - Nutrition Assessment MH - Neutrophils MH - Obesity/immunology/blood MH - Lymphocytes MH - Overweight/immunology/blood PMC - PMC12694329 OTO - NOTNLM OT - BMI OT - CONUT OT - HALP score OT - NLR OT - NRI OT - PLR OT - PNI OT - SII COIS- The authors declare no conflicts of interest. EDAT- 2025/12/11 07:43 MHDA- 2025/12/11 07:44 PMCR- 2025/12/03 CRDT- 2025/12/11 01:04 PHST- 2025/11/04 00:00 [received] PHST- 2025/11/30 00:00 [revised] PHST- 2025/12/02 00:00 [accepted] PHST- 2025/12/11 07:44 [medline] PHST- 2025/12/11 07:43 [pubmed] PHST- 2025/12/11 01:04 [entrez] PHST- 2025/12/03 00:00 [pmc-release] AID - nu17233799 [pii] AID - nutrients-17-03799 [pii] AID - 10.3390/nu17233799 [doi] PST - epublish SO - Nutrients. 2025 Dec 3;17(23):3799. doi: 10.3390/nu17233799. PMID- 41374069 OWN - NLM STAT- MEDLINE DCOM- 20251211 LR - 20251214 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 23 DP - 2025 Dec 2 TI - Do Physical Activity and Diet Independently Account for Variation in Body Fat in Children and Adolescents? A Systematic Review Unpacking the Roles of Exercise and Diet in Childhood Obesity. LID - 10.3390/nu17233779 [doi] LID - 3779 AB - Background/Objectives: Physical activity (PA) and energy intake (EI) are central targets of community initiatives to reduce the prevalence of childhood obesity. The general effects of PA and EI in influencing energy balance and body composition are clear. However, the independent impacts of PA and EI on the adiposity of children growing up amidst westernized lifestyles are inconclusive, as few studies have employed sufficiently robust methodology to provide solid independent associative data. Methods: We carried out a systematic review of the research addressing the independent associations of adiposity with each of PA and EI in free-living town or city-dwelling children and adolescents. Acceptable publications included objective measures of fat mass and PA, best standard practice EI assessments, and appropriate statistical modeling. Results: Of approximately 700 publications explored, only four satisfied all the pre-set methodological standards. All four studies involved predominantly White participants from westernized cities and had the same outcomes. Adiposity was strongly independently and negatively related to PA, but there was no evidence of any independent relationship between adiposity and EI. Potential misreporting was considered, especially under-reporting by participants with greater adiposity, butpost-hoc assessments were unable to find any evidence that this influenced the outcomes. Conclusions: In general, children with higher adiposity consumed no more food and beverage energy than their leaner counterparts, but they were less active. However, despite some support for the validity of the commonly used and validated EI assessments, their subjective nature raises the possibility that inaccuracy masked relationships. Additional well-designed research is needed, and notwithstanding the vital role that sound nutrition plays in the healthy development of our youth, the consistency of outcomes of the well-executed studies in this review suggests that campaigns targeting youth obesity would benefit from strategies focusing strongly on increasing PA. FAU - Telford, Richard D AU - Telford RD AUID- ORCID: 0000-0003-4485-9362 AD - Research Institute for Sport and Exercise, University of Canberra, Bruce, ACT 2617, Australia. AD - Health Research Institute, University of Canberra, Bruce, ACT 2617, Australia. FAU - Jayasinghe, Sisitha AU - Jayasinghe S AUID- ORCID: 0000-0001-8805-385X AD - Independent Researcher, Newcastle NE1 1EN, UK. FAU - Byrne, Nuala M AU - Byrne NM AUID- ORCID: 0000-0001-5310-6640 AD - School of Health Sciences, UTAS Health, University of Tasmania, Launceston, TAS 7250, Australia. FAU - Telford, Rohan M AU - Telford RM AUID- ORCID: 0000-0002-1723-2559 AD - National Centre for Epidemiology and Population Health, Australian National University, Canberra, ACT 2601, Australia. FAU - Hills, Andrew P AU - Hills AP AUID- ORCID: 0000-0002-6849-6116 AD - School of Health Sciences, UTAS Health, University of Tasmania, Launceston, TAS 7250, Australia. LA - eng PT - Journal Article PT - Systematic Review DEP - 20251202 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Adipose Tissue MH - *Adiposity MH - *Diet MH - Energy Intake MH - *Exercise MH - *Pediatric Obesity/prevention & control/epidemiology/physiopathology PMC - PMC12693829 OTO - NOTNLM OT - BMI OT - adolescents OT - body composition OT - childhood obesity OT - diet OT - dietary surveys OT - energy expenditure OT - energy intake OT - percent body fat OT - physical activity OT - sedentarism COIS- The authors declare no conflict of interest. EDAT- 2025/12/11 07:44 MHDA- 2025/12/11 07:45 PMCR- 2025/12/02 CRDT- 2025/12/11 01:04 PHST- 2025/10/31 00:00 [received] PHST- 2025/11/24 00:00 [revised] PHST- 2025/11/30 00:00 [accepted] PHST- 2025/12/11 07:45 [medline] PHST- 2025/12/11 07:44 [pubmed] PHST- 2025/12/11 01:04 [entrez] PHST- 2025/12/02 00:00 [pmc-release] AID - nu17233779 [pii] AID - nutrients-17-03779 [pii] AID - 10.3390/nu17233779 [doi] PST - epublish SO - Nutrients. 2025 Dec 2;17(23):3779. doi: 10.3390/nu17233779. PMID- 41374062 OWN - NLM STAT- MEDLINE DCOM- 20251211 LR - 20251214 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 23 DP - 2025 Nov 30 TI - Effects of Lifestyle, Diet, and Body Composition on Free Testosterone and Cortisol Levels in Young Men. LID - 10.3390/nu17233772 [doi] LID - 3772 AB - Background/Objectives: Testosterone and cortisol are key regulators of metabolic, psychological, and physiological responses to environmental and lifestyle factors. This study aimed to analyze the relationship between free testosterone and cortisol concentrations and dietary patterns, stress levels, sleep quality, physical activity, and body composition in healthy young men (aged 18-35 years). Methods: This study included 40 volunteers who met our inclusion criteria. They underwent anthropometric measurements, body composition analysis, and biochemical determination of serum free testosterone and cortisol concentrations. Additionally, participants completed a set of validated questionnaires: a questionnaire regarding the frequency of consumption of specific foods and stimulants, a 3-day food diary, the PSS-10, the Holmes and Rahe Scale, the PSQI, and the Baecke Physical Activity Questionnaire. Results: Free testosterone concentration in blood was negatively correlated with body fat content and positively correlated with the percentage of energy, protein, fat, sodium, and folic acid requirements. Morning blood cortisol levels negatively correlated with body weight and height. Higher intakes of cholesterol, folic acid, and vitamin A resulted in statistically significant reductions in cortisol levels. A significant correlation was identified between poor sleep quality and low cortisol levels, particularly among men aged < 26 years. A positive correlation was also found between leisure-time physical activity and testosterone levels, particularly in the older group. Furthermore, a higher body weight and greater muscle mass were correlated with lower cortisol levels. Conclusions: These results provide a starting point for further research on neuroendocrine mechanisms in active individuals exposed to environmental stress. FAU - Mazurkiewicz, Dominika AU - Mazurkiewicz D AUID- ORCID: 0000-0002-3225-1053 AD - Department of Human Nutrition, Faculty of Biotechnology and Food Sciences, Wroclaw University of Environmental and Life Sciences, Chelmonskiego 37, 51-630 Wroclaw, Poland. FAU - Gajda, Robert AU - Gajda R AUID- ORCID: 0000-0001-7957-918X AD - Department of Human Nutrition, Faculty of Biotechnology and Food Sciences, Wroclaw University of Environmental and Life Sciences, Chelmonskiego 37, 51-630 Wroclaw, Poland. FAU - Ambrozik-Haba, Jagoda AU - Ambrozik-Haba J AUID- ORCID: 0000-0003-4519-9052 AD - Department of Human Nutrition, Faculty of Biotechnology and Food Sciences, Wroclaw University of Environmental and Life Sciences, Chelmonskiego 37, 51-630 Wroclaw, Poland. FAU - Bozek, Wiktoria AU - Bozek W AD - Department of Human Nutrition, Faculty of Biotechnology and Food Sciences, Wroclaw University of Environmental and Life Sciences, Chelmonskiego 37, 51-630 Wroclaw, Poland. FAU - Ceremuga, Maja AU - Ceremuga M AD - Department of Human Nutrition, Faculty of Biotechnology and Food Sciences, Wroclaw University of Environmental and Life Sciences, Chelmonskiego 37, 51-630 Wroclaw, Poland. FAU - Serek, Pawel AU - Serek P AUID- ORCID: 0000-0002-4685-4373 AD - Department of Human Nutrition, Faculty of Biotechnology and Food Sciences, Wroclaw University of Environmental and Life Sciences, Chelmonskiego 37, 51-630 Wroclaw, Poland. LA - eng GR - The APC is co-financed by Wroclaw University of Environmental and Life Sciences/Wroclaw University of Environmental and Life Sciences/ GR - The APC is co-financed by Wroclaw University of Environmental and Life Sciences/The APC is co-financed by Wroclaw University of Environmental and Life Sciences/ PT - Journal Article DEP - 20251130 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - WI4X0X7BPJ (Hydrocortisone) RN - 3XMK78S47O (Testosterone) SB - IM MH - Humans MH - Male MH - *Hydrocortisone/blood MH - *Testosterone/blood MH - Adult MH - *Body Composition/physiology MH - Young Adult MH - *Life Style MH - Adolescent MH - *Diet MH - Exercise/physiology MH - Sleep Quality MH - Surveys and Questionnaires PMC - PMC12694065 OTO - NOTNLM OT - alcohol OT - cortisol OT - lifestyle OT - nutrition OT - sleep OT - smoking OT - stress OT - testosterone COIS- The authors declare no conflicts of interest. EDAT- 2025/12/11 07:43 MHDA- 2025/12/11 07:44 PMCR- 2025/11/30 CRDT- 2025/12/11 01:04 PHST- 2025/10/29 00:00 [received] PHST- 2025/11/27 00:00 [revised] PHST- 2025/11/28 00:00 [accepted] PHST- 2025/12/11 07:44 [medline] PHST- 2025/12/11 07:43 [pubmed] PHST- 2025/12/11 01:04 [entrez] PHST- 2025/11/30 00:00 [pmc-release] AID - nu17233772 [pii] AID - nutrients-17-03772 [pii] AID - 10.3390/nu17233772 [doi] PST - epublish SO - Nutrients. 2025 Nov 30;17(23):3772. doi: 10.3390/nu17233772. PMID- 41374060 OWN - NLM STAT- MEDLINE DCOM- 20251211 LR - 20251214 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 23 DP - 2025 Nov 30 TI - The Real Danger for Milk Protein Allergy: Developing a Scale for Family Doctors on Introducing Diet Diversity to Infants with Cow's Milk Protein Allergy. LID - 10.3390/nu17233770 [doi] LID - 3770 AB - Background: Cow's milk protein allergy (CMPA) is one of the most common food allergies in infants, with a reported prevalence between 0.54% and 4.9%. In Europe, 1% of children are affected by CMPA in the first 2 years of life. Overdiagnosis leads to unnecessary dietary restrictions, with additional costs, while neglecting the diagnosis of CMPA has long-term repercussions on growth and development or, in the case of an acute reaction, may involve a life-threatening risk. The aim of this study is to develop a scale for family doctors to assess their practical knowledge of allergic pathology in newborns. Materials and Methods: To develop the scale, seven family doctors, each with over 10 years of practical experience, reached a consensus on the 20 items. The items were based on the guidelines of the European Academy of Allergology and Clinical Immunology on the prevention of food allergies in infants and young children. To verify the validity and internal structure of the scale, we conducted a pilot study on family doctors (N = 45), with a predominantly pediatric population, from one of the four university centers in Romania (Iasi region). The results showed a good internal structure of the items in our scale. Content validity showed an I-CVI = 0.79 and an S-CVI = 0.91, which means that the scale can be considered excellent in terms of content. Discussion: The results of our study suggest that the new scale designed to assess the practical knowledge of family physicians in the field of allergic pathology in newborns, particularly with regard to cow's milk protein allergy (CMPA), has solid psychometric properties. The excellent content validity, indicated by an item content validity index (I-CVI) of 0.79 and a scale content validity index (S-CVI) of 0.91, reflects strong agreement among experts on the relevance and comprehensiveness of the items included. Conclusions: The designed scale demonstrates excellent content validity and good internal structure, indicating that it is a reliable tool for assessing the practical knowledge of family physicians in the field of allergic pathology in newborns. This scale can support the improvement of the identification and management of cow's milk protein allergy in primary health care. FAU - Stafie, Celina Silvia AU - Stafie CS AUID- ORCID: 0000-0002-9865-4349 AD - Preventive Medicine and Interdisciplinarity Department, University of Medicine "Grigore T. Popa" Iasi, 700115 Iasi, Romania. LA - eng PT - Journal Article DEP - 20251130 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Milk Proteins) SB - IM MH - Humans MH - *Milk Hypersensitivity/diagnosis/prevention & control/diet therapy MH - Infant MH - *Milk Proteins/immunology/adverse effects MH - Infant, Newborn MH - Female MH - *Physicians, Family MH - Pilot Projects MH - Romania MH - *Diet MH - Male MH - Animals MH - Surveys and Questionnaires MH - Health Knowledge, Attitudes, Practice MH - Reproducibility of Results PMC - PMC12693831 OTO - NOTNLM OT - CMPA OT - breastfeeding OT - cow's milk protein allergy OT - dietary diversity OT - food allergy COIS- The author declares no conflict of interest. EDAT- 2025/12/11 07:42 MHDA- 2025/12/11 07:43 PMCR- 2025/11/30 CRDT- 2025/12/11 01:04 PHST- 2025/10/02 00:00 [received] PHST- 2025/11/22 00:00 [revised] PHST- 2025/11/29 00:00 [accepted] PHST- 2025/12/11 07:43 [medline] PHST- 2025/12/11 07:42 [pubmed] PHST- 2025/12/11 01:04 [entrez] PHST- 2025/11/30 00:00 [pmc-release] AID - nu17233770 [pii] AID - nutrients-17-03770 [pii] AID - 10.3390/nu17233770 [doi] PST - epublish SO - Nutrients. 2025 Nov 30;17(23):3770. doi: 10.3390/nu17233770. PMID- 41374041 OWN - NLM STAT- MEDLINE DCOM- 20251211 LR - 20251214 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 23 DP - 2025 Nov 28 TI - Validity and Reliability of a Food Frequency Questionnaire (NFFQ-Kids) to Assess Food Consumption Based on the Nova Classification in Southern Italian Children and Adolescents. LID - 10.3390/nu17233751 [doi] LID - 3751 AB - Background/Objectives: There is a lack of food frequency questionnaires (FFQs) specifically designed to assess food consumption based on processing levels in younger populations. This study evaluates the validity and the reliability of a 107-item FFQ (NFFQ-Kids) in estimating the intake (g/day) and the weight and energy ratios of Nova groups in Italian children and adolescents aged 2-18 years. Methods: The NFFQ-Kids was administered twice (T0 and T1), with a four-week interval. A total of 73 participants completed the questionnaire at T0, and 53 completed it at T1. Participants were selected from the ICARO Study (December 2023-April 2024), a web-based cohort study in Southern Italy. Questionnaire validity was assessed by comparison with a 3-day food record (two weekdays and one weekend day) collected between the two NFFQ-Kids administrations. Test-retest reliability was evaluated to assess the consistency of the questionnaire over time. Results: A moderate correlation was found between the NFFQ-Kids and the 3-day food record for the energy ratio of ultra-processed foods (UPFs) (r = 0.48; p < 0.001; ICC = 0.46; 95% CI 0.29-0.64) and the weight ratio for both unprocessed or minimally processed foods (r = 0.49; p < 0.001; ICC = 0.50; 95%CI 0.33-0.66) and ultra-processed foods (UPFs) (r = 0.58; p < 0.001; ICC = 0.58; 95%CI 0.42-0.72). Overall, the NFFQ-Kids showed good test-retest reliability across all Nova group intakes, total food, and relative energy and weight ratios of UPFs (r = 0.71, ICC = 0.67; and r = 0.79, ICC = 0.67, respectively), indicating stable measurements over time. Conclusions: The NFFQ-Kids demonstrated acceptable validity and good reliability, proving useful for assessing food intake by processing level in Italian youth. FAU - Paladino, Nadia AU - Paladino N AUID- ORCID: 0000-0002-2463-5321 AD - Department of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania, Italy. FAU - Di Costanzo, Giuseppe AU - Di Costanzo G AUID- ORCID: 0009-0003-3550-7987 AD - Research Unit of Epidemiology and Prevention, Istituto Neurologico Mediterraneo IRCCS NEUROMED, 86077 Pozzilli, Italy. FAU - Ruggiero, Emilia AU - Ruggiero E AUID- ORCID: 0000-0002-7109-1128 AD - Research Unit of Epidemiology and Prevention, Istituto Neurologico Mediterraneo IRCCS NEUROMED, 86077 Pozzilli, Italy. FAU - Di Castelnuovo, Augusto AU - Di Castelnuovo A AD - Research Unit of Epidemiology and Prevention, Istituto Neurologico Mediterraneo IRCCS NEUROMED, 86077 Pozzilli, Italy. FAU - Dello Russo, Marika AU - Dello Russo M AUID- ORCID: 0000-0002-7630-265X AD - Institute of Food Sciences, Consiglio Nazionale delle Ricerche, 83100 Avellino, Italy. FAU - Formisano, Annarita AU - Formisano A AUID- ORCID: 0000-0001-7328-3716 AD - Institute of Food Sciences, Consiglio Nazionale delle Ricerche, 83100 Avellino, Italy. FAU - Lauria, Fabio AU - Lauria F AUID- ORCID: 0000-0002-1663-1582 AD - Institute of Food Sciences, Consiglio Nazionale delle Ricerche, 83100 Avellino, Italy. FAU - Currenti, Walter AU - Currenti W AD - Department of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania, Italy. FAU - Galvano, Fabio AU - Galvano F AUID- ORCID: 0000-0003-0644-0755 AD - Department of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania, Italy. AD - College of Health Science, Princess Nourah Bint Abdulrahman University, Riyad 11564, Saudi Arabia. FAU - Grosso, Giuseppe AU - Grosso G AUID- ORCID: 0000-0003-3930-5285 AD - Department of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania, Italy. AD - Center for Human Nutrition and Mediterranean Foods (NUTREA), University of Catania, 95124 Catania, Italy. FAU - Iacoviello, Licia AU - Iacoviello L AUID- ORCID: 0000-0003-0514-5885 AD - Research Unit of Epidemiology and Prevention, Istituto Neurologico Mediterraneo IRCCS NEUROMED, 86077 Pozzilli, Italy. AD - Department of Medicine and Surgery, LUM University, 70010 Casamassima, Italy. FAU - Bonaccio, Marialaura AU - Bonaccio M AUID- ORCID: 0000-0002-8082-6552 AD - Research Unit of Epidemiology and Prevention, Istituto Neurologico Mediterraneo IRCCS NEUROMED, 86077 Pozzilli, Italy. LA - eng GR - PE0000003/Ministero dell'universita e della ricerca/ PT - Journal Article PT - Validation Study DEP - 20251128 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - Italy MH - Adolescent MH - Reproducibility of Results MH - Male MH - Female MH - Child, Preschool MH - Surveys and Questionnaires/standards MH - *Diet Surveys/methods MH - Diet Records MH - *Feeding Behavior MH - Energy Intake MH - *Diet/statistics & numerical data MH - Fast Foods MH - Nutrition Assessment MH - *Eating PMC - PMC12694190 OTO - NOTNLM OT - Nova classification OT - children/adolescents OT - food frequency questionnaire OT - reliability OT - ultra-processed foods OT - validity COIS- The authors declare no conflicts of interest. EDAT- 2025/12/11 07:43 MHDA- 2025/12/11 07:44 PMCR- 2025/11/28 CRDT- 2025/12/11 01:04 PHST- 2025/10/27 00:00 [received] PHST- 2025/11/21 00:00 [revised] PHST- 2025/11/26 00:00 [accepted] PHST- 2025/12/11 07:44 [medline] PHST- 2025/12/11 07:43 [pubmed] PHST- 2025/12/11 01:04 [entrez] PHST- 2025/11/28 00:00 [pmc-release] AID - nu17233751 [pii] AID - nutrients-17-03751 [pii] AID - 10.3390/nu17233751 [doi] PST - epublish SO - Nutrients. 2025 Nov 28;17(23):3751. doi: 10.3390/nu17233751. PMID- 41374002 OWN - NLM STAT- MEDLINE DCOM- 20251211 LR - 20260127 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 23 DP - 2025 Nov 26 TI - Consumption of Unprocessed and Ultraprocessed Foods in Adolescents with Obesity: Associations with Neuroendocrine Mediators of Appetite Regulation and Binge Eating Symptoms. LID - 10.3390/nu17233711 [doi] LID - 3711 AB - Background/Objectives: Obesity is a multifactorial disease associated with increased consumption of ultraprocessed foods and reduced intake of unprocessed foods. Binge eating, one of the most prevalent eating disorders among adolescents, is closely linked to obesity. Food intake is regulated by both the hedonic system, responsible for reward responses, and the physiological system, which controls hunger and satiety through hormones, such as ghrelin and leptin. The present study aimed to investigate associations between the intake of unprocessed and ultraprocessed foods, neuroendocrine mediators of appetite regulation, and binge eating in adolescents with obesity. Methods: This cross-sectional study included 96 adolescents with obesity who were recruited in Sao Paulo, Brazil, between 2010 and 2012. Anthropometric and body composition assessments were performed. Binge eating symptoms were evaluated using the binge eating scale (BES), and dietary intake was assessed with a validated Food Frequency Questionnaire, with items classified according to the Nova system. Frequency data were converted into annual consumption scores. Serum levels of ghrelin, leptin, neuropeptide Y (NPY), agouti-related peptide (AgRP), melanin-concentrating hormone (MCH), and alpha-melanocyte-stimulating hormone (alpha-MSH) were analyzed. Results: Lower consumption of unprocessed foods was associated with higher ghrelin concentrations (p = 0.023), accompanied by a greater percentage of body fat (p = 0.047) and a reduced percentage of lean mass (p = 0.047) compared with adolescents in the second tertile. AgRP was a positive predictor of annual consumption score of ultraprocessed food (beta = 0.30; p = 0.04), independent of age, body fat, and binge eating symptoms. Conclusions: In conclusion, lower intake of unprocessed foods was associated with alterations in orexigenic and anorexigenic mediators, suggesting that dietary patterns in adolescents with obesity may influence the neuroendocrine mediators of appetite regulation. FAU - Neres, Patricia Sousa AU - Neres PS AD - Programa de Mestrado Profissional em Nutricao: do Nascimento a Adolescencia, Curso de Nutricao, Centro Universitario Sao Camilo (CUSC), Sao Paulo 05025-010, SP, Brazil. FAU - Ganen, Aline de Piano AU - Ganen AP AUID- ORCID: 0000-0001-6433-0816 AD - Programa de Mestrado Profissional em Nutricao: do Nascimento a Adolescencia, Curso de Nutricao, Centro Universitario Sao Camilo (CUSC), Sao Paulo 05025-010, SP, Brazil. FAU - Campos, Raquel Munhoz da Silveira AU - Campos RMDS AUID- ORCID: 0000-0001-6132-4349 AD - Programa de Pos-Graduacao Interdisciplinar em Ciencias da Saude, Departamento de Biociencias, Universidade Federal de Sao Paulo (UNIFESP), Campus Baixada Santista, Santos 11010-150, SP, Brazil. FAU - Carvalho Ferreira, Joana Pereira de AU - Carvalho Ferreira JP AUID- ORCID: 0000-0001-9038-2185 AD - Laboratorio Multidisciplinar em Alimentos e Saude, Faculdade de Ciencias Aplicadas, Universidade Estadual de Campinas (UNICAMP), Limeira 13484-350, SP, Brazil. FAU - Oyama, Lila Missae AU - Oyama LM AUID- ORCID: 0000-0002-7078-6526 AD - Programa de Pos-Graduacao em Nutricao, Departamento de Fisiologia, Universidade Federal de Sao Paulo (UNIFESP), Campus Sao Paulo, Sao Paulo 04023-061, SP, Brazil. FAU - Damaso, Ana Raimunda AU - Damaso AR AUID- ORCID: 0000-0001-7675-7470 AD - Programa de Pos-Graduacao em Nutricao, Departamento de Fisiologia, Universidade Federal de Sao Paulo (UNIFESP), Campus Sao Paulo, Sao Paulo 04023-061, SP, Brazil. FAU - Masquio, Deborah Cristina Landi AU - Masquio DCL AUID- ORCID: 0000-0003-0187-6402 AD - Programa de Mestrado Profissional em Nutricao: do Nascimento a Adolescencia, Curso de Nutricao, Centro Universitario Sao Camilo (CUSC), Sao Paulo 05025-010, SP, Brazil. AD - Programa de Pos-Graduacao em Nutricao, Departamento de Fisiologia, Universidade Federal de Sao Paulo (UNIFESP), Campus Sao Paulo, Sao Paulo 04023-061, SP, Brazil. LA - eng GR - 305240/2021-8/National Council for Scientific and Technological Development/ GR - 2566/2011/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ GR - 2006/00684-3; 2008/53069-0; 2011/50356-0; 2011/50414-0; 2013/041364/Fundacao de Amparo a Pesquisa do Estado de Sao Paulo/ PT - Journal Article DEP - 20251126 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Ghrelin) RN - 0 (Leptin) RN - 0 (Neuropeptide Y) RN - 581-05-5 (alpha-MSH) RN - 0 (Melanins) RN - 67382-96-1 (melanin-concentrating hormone) RN - 0 (Agouti-Related Protein) RN - 0 (Pituitary Hormones) RN - 0 (Hypothalamic Hormones) SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - Cross-Sectional Studies MH - Ghrelin/blood MH - *Appetite Regulation/physiology MH - Leptin/blood MH - *Bulimia/blood MH - Brazil MH - *Pediatric Obesity/blood/physiopathology MH - Neuropeptide Y/blood MH - alpha-MSH/blood MH - Melanins/blood MH - Agouti-Related Protein/blood MH - Pituitary Hormones/blood MH - Feeding Behavior MH - *Fast Foods/adverse effects MH - Binge-Eating Disorder MH - Body Composition MH - *Diet MH - Hypothalamic Hormones PMC - PMC12694064 OTO - NOTNLM OT - adolescent OT - energy balance OT - neuroendocrine mediators OT - obesity OT - ultraprocessed food OT - unprocessed food COIS- The authors declare no conflicts of interest. EDAT- 2025/12/11 07:43 MHDA- 2025/12/11 07:44 PMCR- 2025/11/26 CRDT- 2025/12/11 01:04 PHST- 2025/09/25 00:00 [received] PHST- 2025/11/05 00:00 [revised] PHST- 2025/11/19 00:00 [accepted] PHST- 2025/12/11 07:44 [medline] PHST- 2025/12/11 07:43 [pubmed] PHST- 2025/12/11 01:04 [entrez] PHST- 2025/11/26 00:00 [pmc-release] AID - nu17233711 [pii] AID - nutrients-17-03711 [pii] AID - 10.3390/nu17233711 [doi] PST - epublish SO - Nutrients. 2025 Nov 26;17(23):3711. doi: 10.3390/nu17233711. PMID- 41373943 OWN - NLM STAT- MEDLINE DCOM- 20251211 LR - 20251214 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 23 DP - 2025 Nov 21 TI - Ultra-Processed Foods Consumption, Mediterranean Diet Adherence and Sociodemographic Correlates in an Italian Adult Population: The UFO Survey. LID - 10.3390/nu17233651 [doi] LID - 3651 AB - Background: Although national surveys report increasing ultra-processed foods (UPFs) consumption, updated estimates for Italy are lacking. Given the central role of the Mediterranean Diet (MD), understanding how UPFs contribute to the contemporary Italian diet is essential. This study quantified UPF intake in a convenience sample of Italian adults and examined its main sociodemographic correlates, including MD adherence. Methods: A web-based cross-sectional survey was conducted among Italian adults (>/=18 years). Dietary intake was assessed using the validated 94-item NOVA Food Frequency Questionnaire (NFFQ). Associations between sociodemographic factors and NOVA food groups were evaluated using multivariable-adjusted linear regression, expressed as beta coefficients (beta) and 95% confidence intervals (95% CI). MD adherence was assessed using the Medi-Lite score. Results: Data from 1629 participants (79.8% women; mean age 42.1 years, range 18-85) recruited between September 2021 and April 2025 were analyzed. Participants resided in Northern (23.4%), Central (40.4%), and Southern Italy (36.2%). UPFs contributed 20.0% (95% CI: 19.5-20.6) of total energy intake, while unprocessed/minimally processed foods, processed culinary ingredients, and processed foods accounted for 39.2%, 9.0%, and 31.8%, respectively. UPF consumption decreased with age (beta = -3.34; 95% CI: -5.96 to -0.72 for >64 vs. 0.05). The PNR demonstrates a significant association with HU use and HbF levels, indicating its potential as a low-cost, accessible biomarker for monitoring HU therapy in SCD. Although this analysis was based on data from a high-resource setting, the findings underscore the relevance of PNR as a feasible monitoring alternative in resource-constrained environments. Further validation in low-income contexts is warranted to establish population-specific reference intervals and inform clinical practice. CI - (c) 2025. The Author(s). FAU - Chibuife, Efobi Chilota AU - Chibuife EC AD - Department of Haematology and Blood Transfusion, Faculty of Basic Clinical Sciences, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria. FAU - Chisom Adaobi, Nri-Ezedi AU - Chisom Adaobi NE AD - Department of Paediatrics, Faculty of Medicine, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria. ca.nri-ezedi@unizik.edu.ng. AD - Department of Paediatrics, Nnamdi Azikiwe University, Awka, Anambra, Nigeria. ca.nri-ezedi@unizik.edu.ng. FAU - Odini, Franklin AU - Odini F AD - Department of Community Medicine, Federal Medical Centre, Umuahia, Abia State, Nigeria. FAU - Deepika, Habib Darbari AU - Deepika HD AD - Division of Hematology, Children's National Hospital and George Washington University School of Medicine and Health Sciences, Washington, DC, USA. FAU - Habib, Nana-Bilkisu AU - Habib NB AD - Division of Hematology, Children's National Hospital and George Washington University School of Medicine and Health Sciences, Washington, DC, USA. FAU - Andrew, Campbell AU - Andrew C AD - Division of Hematology, Children's National Hospital and George Washington University School of Medicine and Health Sciences, Washington, DC, USA. LA - eng PT - Journal Article DEP - 20251210 PL - Germany TA - Ann Hematol JT - Annals of hematology JID - 9107334 RN - X6Q56QN5QC (Hydroxyurea) RN - 9034-63-3 (Fetal Hemoglobin) RN - 0 (Biomarkers) RN - 0 (Antisickling Agents) SB - IM MH - Humans MH - *Hydroxyurea/therapeutic use MH - *Anemia, Sickle Cell/drug therapy/blood/economics/epidemiology MH - Male MH - Female MH - *Neutrophils MH - Retrospective Studies MH - Child MH - Adolescent MH - Fetal Hemoglobin/analysis MH - *Blood Platelets MH - Child, Preschool MH - Platelet Count MH - Nigeria/epidemiology MH - Developing Countries MH - Poverty MH - *Drug Monitoring/methods MH - Biomarkers/blood MH - Antisickling Agents/therapeutic use PMC - PMC12764571 OTO - NOTNLM OT - Foetal haemoglobin OT - Hydroxyurea OT - Low-resource settings OT - Platelet-to-neutrophil ratio OT - Sickle cell disease COIS- Declarations. Ethical approval: Ethical approval for the study was obtained from the institutional review board (IRB) at Children's National Hospital, Washington DC, United States of America.. IRB number: Pro00010744 Consent to participate: As this was a retrospective chart review using de-identified data, individual patient consent was waived by the IRB in accordance with ethical regulations and the principles outlined in the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/10 13:51 MHDA- 2026/01/04 06:36 PMCR- 2025/12/10 CRDT- 2025/12/10 11:22 PHST- 2025/06/01 00:00 [received] PHST- 2025/08/22 00:00 [accepted] PHST- 2026/01/04 06:36 [medline] PHST- 2025/12/10 13:51 [pubmed] PHST- 2025/12/10 11:22 [entrez] PHST- 2025/12/10 00:00 [pmc-release] AID - 10.1007/s00277-025-06598-2 [pii] AID - 6598 [pii] AID - 10.1007/s00277-025-06598-2 [doi] PST - ppublish SO - Ann Hematol. 2025 Dec;104(12):6161-6168. doi: 10.1007/s00277-025-06598-2. Epub 2025 Dec 10. PMID- 41367997 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251210 LR - 20251212 IS - 2949-7329 (Electronic) IS - 2949-7329 (Linking) VI - 3 IP - 4 DP - 2025 Dec TI - Wearable Signals for Diagnosing Attention-Deficit/Hyperactivity Disorder in Adolescents: A Feasibility Study. PG - 875-889 LID - 10.1016/j.jaacop.2024.11.003 [doi] AB - OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder in children and adolescents. Diagnoses of ADHD often rely on subjective ratings from parents and teachers. This study investigated the feasibility of using objective activity monitoring data collected through wearable activity trackers for ADHD diagnosis and monitoring in adolescents. METHOD: A longitudinal study was conducted involving Chinese adolescents ages 16 to 17 years. Data collected included objective measures (movement acceleration, heart rate, and sleep patterns from passive actigraphy) and subjective measures (parent and self-reported questionnaires). Machine learning models were developed using eXtreme Gradient Boosting (XGBoost) to compare various measures for ADHD classification. Model performance was evaluated using the area under the receiver operating characteristics curve (AUC). The SHapley Additive exPlanations (SHAP) method was used to analyze the importance of different measures on ADHD risk. RESULTS: The study included 30 adolescents (17 with ADHD and 13 without ADHD). Machine learning models using solely objective measures achieved high predictability in classifying ADHD (AUC = 0.844) and ADHD medication status (AUC = 1.000). Models integrating both subjective and objective measures showed enhanced performance (AUC = 0.933). In this sample, key features for ADHD classification included irritability, sex, and quality-of-life indicators; key features for ADHD medication use classification included heart rate and physical activity intensity. CONCLUSION: Although the sample size was small, actigraphy-based monitoring provides a noninvasive and granular measurement of objective vital signs of adolescents. If validated in larger samples, the incorporation of objective measures is likely to enhance multidimensional assessment and diagnostic accuracy in adolescents with ADHD, supplementing existing diagnostic methods. STUDY PREREGISTRATION INFORMATION: A systematic review of anhedonia and amotivation in depression and cannabis use; https://www.crd.york.ac.uk/prospero/; CRD42023422438. CI - (c) 2024 The Authors. FAU - Jiang, Zhihan AU - Jiang Z AD - Faculty of Engineering, The University of Hong Kong, Hong Kong SAR, China. FAU - Chan, Adrienne Y L AU - Chan AYL AD - Groningen Research Institute of Pharmacy, Unit of Pharmacotherapy Epidemiology and Economics, University of Groningen, Groningen, The Netherlands. AD - Laboratory of Data Discovery for Health (D24H), The University of Hong Kong, Hong Kong SAR, China. AD - School of Pharmacy, University College London, London, United Kingdom. AD - Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. FAU - Lum, Dawn AU - Lum D AD - Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. FAU - Wong, Kirstie H T W AU - Wong KHTW AD - School of Pharmacy, University College London, London, United Kingdom. AD - Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. AD - Hong Kong Children's Hospital, Hong Kong SAR, China. FAU - Leung, Janice C N AU - Leung JCN AD - Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. FAU - Ip, Patrick AU - Ip P AD - Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. AD - Hong Kong Children's Hospital, Hong Kong SAR, China. FAU - Coghill, David AU - Coghill D AD - University of Melbourne, Melbourne, Victoria, Australia. FAU - Wong, Rosa S AU - Wong RS AD - Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. FAU - Ngai, Edith C H AU - Ngai ECH AD - Faculty of Engineering, The University of Hong Kong, Hong Kong SAR, China. FAU - Wong, Ian C K AU - Wong ICK AD - Laboratory of Data Discovery for Health (D24H), The University of Hong Kong, Hong Kong SAR, China. AD - School of Pharmacy, University College London, London, United Kingdom. AD - Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. AD - Aston School of Pharmacy, Aston University, Birmingham, United Kingdom. LA - eng PT - Journal Article DEP - 20241125 PL - United States TA - JAACAP Open JT - JAACAP open JID - 9918627288306676 PMC - PMC12684460 OAB - This study explores the feasibility of using commercial wrist-worn activity trackers in addition to parent- and self-report questionnaires to diagnose and monitor attention-deficit/hyperactivity disorder (ADHD) in Chinese adolescents. The data collected from 30 adolescents (17 with ADHD and 13 without ADHD) for 12 weeks, including movement patterns and heart rate, were used to develop machine learning models for ADHD identification and medication status classification. The experimental results combined and compared with traditional parent- and self-report questionnaires suggest that wearable trackers could offer an objective way to assess ADHD, potentially supplementing existing diagnostic methods and monitoring for this condition. If validated in larger samples, the incorporation of objective measures is likely to enhance multidimensional assessment and diagnostic accuracy in adolescents with ADHD. OABL- eng OTO - NOTNLM OT - ADHD OT - activity monitoring OT - machine learning OT - wearable devices EDAT- 2025/12/10 06:28 MHDA- 2025/12/10 06:29 PMCR- 2024/11/25 CRDT- 2025/12/10 04:49 PHST- 2024/11/18 00:00 [accepted] PHST- 2025/12/10 06:29 [medline] PHST- 2025/12/10 06:28 [pubmed] PHST- 2025/12/10 04:49 [entrez] PHST- 2024/11/25 00:00 [pmc-release] AID - S2949-7329(24)00091-7 [pii] AID - 10.1016/j.jaacop.2024.11.003 [doi] PST - epublish SO - JAACAP Open. 2024 Nov 25;3(4):875-889. doi: 10.1016/j.jaacop.2024.11.003. eCollection 2025 Dec. PMID- 41367939 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251210 LR - 20251212 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 16 DP - 2025 TI - Loneliness and nervousness mediated the longitudinal association between sleep disorders and cyberbullying victimization in school-aged adolescents. PG - 1640989 LID - 10.3389/fpsyt.2025.1640989 [doi] LID - 1640989 AB - BACKGROUND: This study investigated the longitudinal dose-response relationship between sleep disorders and cyberbullying victimization in school-aged adolescents and explored the mediating roles of psychological factors (loneliness, sadness, and nervousness). METHODS: A 2-year longitudinal design was used to collect self-reported data on sleep disorders, physical activity, screen time, smoking, alcohol use, and dieting behavior. Cyberbullying victimization was assessed during follow-up. Multivariate logistic regression analysis and restricted cubic splines (RCSs) were used to analyze the dose-response relationship between sleep disorders and cyberbullying victimization. The mediation analysis explored indirect effects through loneliness, sadness, and nervousness. RESULTS: Among the 1,910 adolescents (mean age: 12.2 +/- 0.47 years), the mean sleep disorder score was 3.32 +/- 3.68 (range: 0-27.0), and 196 (10.3%) engaged in cyberbullying victimization during the follow-up period. Sleep disorders were significantly associated with an increased risk of cyberbullying victimization (OR: 1.10, 95% CI: 1.06-1.14) after adjusting for confounders. Sensitivity analyses further validated the robustness of the results, which revealed that the risk of cyberbullying victimization increased approximately with increasing prevalence of sleep disorders. The RCS curve revealed that the risk of cyberbullying victimization increased approximately linearly with increasing prevalence of sleep disorders (P for overall<0.001, P for nonlinear=0.915). Compared with boys, girls with more sleep disorders presented a slightly greater risk of cyberbullying victimization (adjusted OR: 1.14 vs.1.08). Loneliness and nervousness partially mediated the association between sleep disorders and cyberbullying victimization, accounting for 25.00% (indirect effect beta = 0.003, P < 0.001) and 8.33% (indirect effect beta = 0.001, P = 0.038) of the total effect, whereas sadness had no significant effect. CONCLUSIONS: Sleep disorders independently predict cyberbullying victimization in adolescents, with stronger effects observed in girls. Loneliness and nervousness partially mediate this association. Targeted interventions to improve sleep, reduce loneliness and nervousness, and sex-specific strategies may mitigate cyberbullying victimization in school-aged adolescents. CI - Copyright (c) 2025 Xiao, Jiang, Lei, Wang, Li and Gong. FAU - Xiao, Xin AU - Xiao X AD - Visual Science and Optometry Center of Guangxi, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. AD - Scientific Research Department, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. AD - Guangxi Key Laboratory of Eye Health, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. AD - Guangxi Health Commission Key Laboratory of Ophthalmology and Related Systemic Diseases Artificial Intelligence Screening Technology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. FAU - Jiang, Zu-Ling AU - Jiang ZL AD - Scientific Research Department, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi, China. FAU - Lei, Qiong AU - Lei Q AD - Department of Ophthalmology, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, Guangxi, China. FAU - Wang, Si-Jia AU - Wang SJ AD - Department of School Health, Ningbo Municipal Center for Disease Control and Prevention, Ningbo, Zhejiang, China. FAU - Li, Si-Xuan AU - Li SX AD - Department of School Health, Ningbo Municipal Center for Disease Control and Prevention, Ningbo, Zhejiang, China. FAU - Gong, Qing-Hai AU - Gong QH AD - Department of School Health, Ningbo Municipal Center for Disease Control and Prevention, Ningbo, Zhejiang, China. LA - eng PT - Journal Article DEP - 20251124 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC12682890 OTO - NOTNLM OT - adolescents OT - cyberbullying victimization OT - loneliness OT - mediation effect OT - nervousness OT - sleep disorders COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/10 06:28 MHDA- 2025/12/10 06:29 PMCR- 2025/11/24 CRDT- 2025/12/10 04:49 PHST- 2025/06/04 00:00 [received] PHST- 2025/10/30 00:00 [accepted] PHST- 2025/12/10 06:29 [medline] PHST- 2025/12/10 06:28 [pubmed] PHST- 2025/12/10 04:49 [entrez] PHST- 2025/11/24 00:00 [pmc-release] AID - 10.3389/fpsyt.2025.1640989 [doi] PST - epublish SO - Front Psychiatry. 2025 Nov 24;16:1640989. doi: 10.3389/fpsyt.2025.1640989. eCollection 2025. PMID- 41365980 OWN - NLM STAT- MEDLINE DCOM- 20260108 LR - 20260121 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2025 Dec 9 TI - Effect of finger millet diet on mental health and meta cognitive skills in young adult athletes and non-athletes. PG - 937 LID - 10.1038/s41598-025-30523-2 [doi] LID - 937 AB - Mental health issues are prevalent among athletes as well as non-athletes due to various psycho-physiological and environmental stresses. Finger millet being rich in antioxidants, polyphenols and high fibre, can be potentially effective in maintaining and improving mental health and cognition. Hence, the present study aims to evaluate the effects of the finger millet diet on mental health and meta-cognitive skills in athletes and non-athletes. 57 participants (males; 27 athletes and 30 non-athletes; 18 to 25 years) were randomly divided into experimental (EGA: experimental group athletes; n = 15; EGNA: experimental group non-athletes; n = 15) and control (CGA: control group athletes; n = 12; CGNA: control group non-athletes; n = 15) groups. The experimental group was provided with a finger millet diet (replacing 1/3rd of daily regular cereals) and a control group with a regular (rice/wheat) diet for 60 days. Mental health and meta-cognitive skills were measured via validated questionnaires. The SMHAT scores showed a significant decrease in sleep disturbance (p = 0.008) and a declining trend in depression (p = 0.059) and anxiety (p = 0.087) in EGA and no significant difference in CGA. The MHI scores showed significantly increased anxiety (p = 0.050), depression (p = 0.010) and psychological distress (p = 0.012) in CGNA while EGNA showed no significant difference in pre and post-test. MCSS subscales viz., implementation (p = 0.040), monitoring (p = 0.013) and total meta-cognitive skills scores showed significant improvement in EGA (p = 0.050) and no significant changes in CGA, EGNA and CGNA. Finger millet helps in improving mental health, sleep quality and meta-cognitive skills in athletes and help in the maintenance of mental health in non-athletes. CI - (c) 2025. The Author(s). FAU - Tanwar, Ekta AU - Tanwar E AD - Department of Nutrition and Dietetics, School of Allied Health Sciences, Manav Rachna International Institute of Research and Studies, Faridabad, 121004, Haryana, India. FAU - Kalpana, Kommi AU - Kalpana K AD - Department of Nutrition and Dietetics, School of Allied Health Sciences, Manav Rachna International Institute of Research and Studies, Faridabad, 121004, Haryana, India. kommikalpana80@gmail.com. FAU - Khanna, Gulshan Lal AU - Khanna GL AD - Manav Rachna International Institute of Research & Studies, Faridabad, 121004, Haryana, India. FAU - Rao, Benhur Dayakar AU - Rao BD AD - ICAR- Indian Institute of Millets Research, Hyderabad, India. FAU - Saifi, Alisha AU - Saifi A AD - Department of Nutrition and Dietetics, School of Allied Health Sciences, Manav Rachna International Institute of Research and Studies, Faridabad, 121004, Haryana, India. LA - eng GR - F. No18-3/2022-NFSM(FTS111307E/This research was funded by the Ministry of Agriculture and Farmers Welfare, Department of Agriculture and Farmers Welfare, Division of Crops and Post Harvest Management of Food Grain, Govt of India/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20251209 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Young Adult MH - *Athletes/psychology MH - *Mental Health MH - *Cognition MH - Adolescent MH - *Eleusine MH - *Diet MH - Depression MH - Anxiety/diet therapy PMC - PMC12783109 OTO - NOTNLM OT - Athletes OT - Daytime sleepiness OT - Eating disorders OT - Finger millet OT - Mental health OT - Meta cognitive skills OT - Sleep quality COIS- Declarations. Competing interests: The authors declare no competing interests. Patient and public involvement: Patients and/or the public were not involved in the design, conduct, reporting, or dissemination plans of this research. Ethics approval: This study involves human participants and was approved by the Institutional Ethics Committee, Manav Rachna International Institute of Research and Studies (Ref. No: EC/2023-24/036 dated 24/07/2023) and Clinical Trial Registry of India (CTRI) (Ref No. CTRI/2023/10/059332 dated 31/10/2023). Participants gave informed consent to participate in the study before taking part. Patient and public involvement: Patients and/or the public were not involved in the design, conduct, reporting, or dissemination plans of this research. Equity, diversity and inclusion statement: All study participants were male students (aged 18 to 25 years), inclusive of all race, ethnicities, regions, religions, socioeconomic levels, and occurrences in a marginalized community. Our research team consisted of 3 females and 2 males from different disciplines (nutrition, exercise physiology and agriculture) with ranks from principal scientist to research scholars of different ethnicities, cultures, religions, geographical areas and socio-economic levels. However, all the study participants and research team belonged to the same country, India. EDAT- 2025/12/10 01:47 MHDA- 2026/01/09 00:26 PMCR- 2025/12/09 CRDT- 2025/12/09 23:21 PHST- 2024/10/24 00:00 [received] PHST- 2025/11/25 00:00 [accepted] PHST- 2026/01/09 00:26 [medline] PHST- 2025/12/10 01:47 [pubmed] PHST- 2025/12/09 23:21 [entrez] PHST- 2025/12/09 00:00 [pmc-release] AID - 10.1038/s41598-025-30523-2 [pii] AID - 30523 [pii] AID - 10.1038/s41598-025-30523-2 [doi] PST - epublish SO - Sci Rep. 2025 Dec 9;16(1):937. doi: 10.1038/s41598-025-30523-2. PMID- 41362242 OWN - NLM STAT- MEDLINE DCOM- 20260213 LR - 20260813 IS - 1475-2662 (Electronic) IS - 0007-1145 (Print) IS - 0007-1145 (Linking) VI - 135 IP - 3 DP - 2026 Feb 14 TI - Impact of early neonatal nutrition on neurodevelopment and the limbic system in very low birth weight infants. PG - 286-296 LID - 10.1017/S0007114525105874 [doi] AB - The limbic system is a brain structure involved in emotional regulation. Since nutritional interventions in very low birth weight (VLBW) infants may be associated with measurable differences in brain structure and function, we designed this prospective study to evaluate the impact of early nutritional support in VLBW infants on the volume of the regions that comprise the limbic system, as well as on the emotional and neuropsychological development of these infants. This is a prospective observational study of a historical cohort of children with a history of prematurity. Seventy-four preterm infants, with a mean age of 11.1 (sd 2.9) years, underwent neuropsychological assessment using the Wechsler Intelligence Scale for Children and functional MRI (fMRI). We recorded the nutritional intake during the first week of the neonatal period, as well as data related to neonatal morbidity. The association between the results of the brain structural analysis, psychometrics variables and nutritional intake was determined using simple and multivariate linear regression adjusted for child age and BMI in the structural analysis of fMRI. Lipids intake was also associated with the volume of the left thalamus (b = 50.7; P = 0.014), the right thalamus (b = 47.4; P = 0.018) and the left nucleus accumbens (b = 5.02; P = 0.031). We conclude that lipids intake in the first week of life in VLBW newborns is associated with the volume of various structures of the limbic system, namely the thalamus and the nucleus accumbens. FAU - Uberos, Jose AU - Uberos J AUID- ORCID: 0000-0002-3519-6678 AD - Department of Paediatrics, School of Medicine, https://ror.org/04njjy449Granada University, Granada, Spain. AD - Neonatal Intensive Care Unit, https://ror.org/02pnm9721San Cecilio Clinical Hospital, Medicine Faculty, Granada, Spain. AD - https://ror.org/026yy9j15Instituto de Investigacion Biosanitaria (ibs.GRANADA), Health Sciences Technological Park, Granada, Spain. FAU - Carrasco-Solis, Marta AU - Carrasco-Solis M AD - Neuropaediatrics Unit, Paediatrics Service, San Cecilio Clinical Hospital, Granada, Spain. AD - Center of Psychology and Neuropsychology (a)LPEH, Granada, Spain. FAU - Laynez-Rubio, Carolina AU - Laynez-Rubio C AD - Neuropaediatrics Unit, Paediatrics Service, San Cecilio Clinical Hospital, Granada, Spain. FAU - Nieto-Ruiz, Ana AU - Nieto-Ruiz A AD - Department of Behavioural Science Methodology, Faculty of Psychology, University of Granada, Granada, Spain. AD - EURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, Department of Paediatrics, Faculty of Medicine, University of Granada, Granada, Spain. AD - https://ror.org/026yy9j15Instituto de Investigacion Biosanitaria (ibs.GRANADA), Health Sciences Technological Park, Granada, Spain. FAU - Ruiz-Lopez, Aida AU - Ruiz-Lopez A AD - Neonatal Intensive Care Unit, https://ror.org/02pnm9721San Cecilio Clinical Hospital, Medicine Faculty, Granada, Spain. FAU - Contreras-Chova, Francisco AU - Contreras-Chova F AD - Department of Paediatrics, School of Medicine, https://ror.org/04njjy449Granada University, Granada, Spain. FAU - Fernandez-Marin, Elizabeth AU - Fernandez-Marin E AD - Neonatal Intensive Care Unit, https://ror.org/02pnm9721San Cecilio Clinical Hospital, Medicine Faculty, Granada, Spain. FAU - Campos-Martinez, Ana AU - Campos-Martinez A AD - Department of Paediatrics, School of Medicine, https://ror.org/04njjy449Granada University, Granada, Spain. AD - Neonatal Intensive Care Unit, https://ror.org/02pnm9721San Cecilio Clinical Hospital, Medicine Faculty, Granada, Spain. AD - https://ror.org/026yy9j15Instituto de Investigacion Biosanitaria (ibs.GRANADA), Health Sciences Technological Park, Granada, Spain. CN - Collaborative NeuroPrem group LA - eng PT - Journal Article PT - Observational Study DEP - 20251209 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM MH - Humans MH - *Infant, Very Low Birth Weight/growth & development MH - Infant, Newborn MH - *Limbic System/growth & development MH - Prospective Studies MH - Female MH - Male MH - Magnetic Resonance Imaging MH - *Infant Nutritional Physiological Phenomena MH - *Child Development MH - Infant, Premature/growth & development MH - Child MH - Neuropsychological Tests MH - Thalamus/growth & development PMC - PMC12912837 OTO - NOTNLM OT - Limbic system OT - Nucleus accumbens OT - Nutrition OT - Thalamus OT - Very low birth weight infants EDAT- 2025/12/09 07:38 MHDA- 2026/02/13 12:50 PMCR- 2026/02/17 CRDT- 2025/12/09 03:42 PHST- 2026/02/13 12:50 [medline] PHST- 2025/12/09 07:38 [pubmed] PHST- 2025/12/09 03:42 [entrez] PHST- 2026/02/17 00:00 [pmc-release] AID - S0007114525105874 [pii] AID - 10.1017/S0007114525105874 [doi] PST - ppublish SO - Br J Nutr. 2026 Feb 14;135(3):286-296. doi: 10.1017/S0007114525105874. Epub 2025 Dec 9. PMID- 41361808 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260926 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2025 Dec 8 TI - Mediating pathways between area-level deprivation and hypertension in Nepal: the role of nutritional status, food insecurity, and health behaviors. PG - 172 LID - 10.1186/s12889-025-25471-5 [doi] LID - 172 AB - BACKGROUND: Hypertension is a major contributor to global disease burden, and the prevalence is associated to various social determinants, including area-level deprivation. However, the mechanisms underlying this association remain unclear, particularly in low- and middle-income countries (LMICs). This study explores how household food insecurity, individual behaviors (smoking and alcohol use), and nutritional status may mediate the relationship between area-level deprivation and hypertension in Nepal. METHODS: We used nationally representative data from the 2016 Nepal Demographic and Health Survey. Area-level deprivation was measured using a validated 15-item composite index. A two-level structural equation model was employed to analyze both the direct and indirect (mediated) relationships between deprivation and hypertension, with individuals (aged >/= 15 years) and households nested within geographic clusters/areas. RESULTS: The overall prevalence of hypertension was 22.9%, with a higher rate in less deprived (more affluent) areas (27.5%) compared to highly deprived ones (17.9%). When mediators were not included, area-level deprivation was inversely associated with hypertension. However, when potential mediators-Body Mass Index (BMI; as a proxy for nutritional status), household food insecurity, and individual behaviors (smoking and alcohol use) were included, the direct effect of deprivation on hypertension was no longer significant. BMI emerged as the only significant mediator, accounting for approximately 70% of the total indirect effect. Food insecurity and individual behaviors did not significantly mediate the relationship; although, food insecurity was associated with lower hypertension risk and individual health behaviors (smoking and alcohol use) with higher risk at the individual level. CONCLUSION: In the context of Nepal, hypertension is more prevalent in affluent areas, and BMI- a proxy for nutritional status significantly mediates the link between area-level deprivation and hypertension risk. These findings highlight the role of nutritional transitions in LMICs and the need for context-specific public health strategies targeting both environmental and individual-level factors. FAU - Sharma, Ishor AU - Sharma I AD - Department of Epidemiology and Biostatistics, Western University, London, ON, Canada. isharm9@uwo.ca. FAU - Campbell, M Karen AU - Campbell MK AD - Department of Epidemiology and Biostatistics, Western University, London, ON, Canada. AD - Department of Pediatrics, Western University, London, ON, Canada. AD - Children's Health Research Institute, London, ON, Canada. AD - Lawson Health Research Institute, London, ON, Canada. AD - Department of Obstetrics and Gynecology, Western University, London, ON, Canada. FAU - Choi, Yun-Hee AU - Choi YH AD - Department of Epidemiology and Biostatistics, Western University, London, ON, Canada. FAU - Luginaah, Isaac AU - Luginaah I AD - Department of Geography, Western University, London, ON, Canada. FAU - Were, Jason Mulimba AU - Were JM AD - Department of Epidemiology and Biostatistics, Western University, London, ON, Canada. FAU - Vargas-Gonzalea, Juan-Camilo AU - Vargas-Gonzalea JC AD - Department of Epidemiology and Biostatistics, Western University, London, ON, Canada. FAU - Stranges, Saverio AU - Stranges S AD - Department of Epidemiology and Biostatistics, Western University, London, ON, Canada. AD - Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy. AD - The Africa Institute, Western University, London, ON, Canada. AD - Department of family Medicine, Western University, London, ON, Canada. AD - Department of Medicine, Schulich school of medicine and Dentistry, Western University, London, ON, Canada. LA - eng PT - Journal Article DEP - 20251208 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Nepal/epidemiology MH - *Hypertension/epidemiology MH - *Food Insecurity MH - *Nutritional Status MH - Female MH - *Health Behavior MH - Adult MH - Male MH - Adolescent MH - Health Surveys MH - Middle Aged MH - Young Adult MH - Socioeconomic Disparities in Health MH - Prevalence MH - Poverty PMC - PMC12802185 OTO - NOTNLM OT - Area-level deprivation OT - Hypertension OT - Multilevel-Mediation COIS- Declarations. Ethics approval and consent to participate: Not Applicable. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/09 07:38 MHDA- 2026/06/27 00:59 PMCR- 2025/12/08 CRDT- 2025/12/09 00:26 PHST- 2025/06/22 00:00 [received] PHST- 2025/10/28 00:00 [accepted] PHST- 2026/06/27 00:59 [medline] PHST- 2025/12/09 07:38 [pubmed] PHST- 2025/12/09 00:26 [entrez] PHST- 2025/12/08 00:00 [pmc-release] AID - 10.1186/s12889-025-25471-5 [pii] AID - 25471 [pii] AID - 10.1186/s12889-025-25471-5 [doi] PST - epublish SO - BMC Public Health. 2025 Dec 8;26(1):172. doi: 10.1186/s12889-025-25471-5. PMID- 41361802 OWN - NLM STAT- MEDLINE DCOM- 20260114 LR - 20260116 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2025 Dec 9 TI - Social and socioeconomic determinants of health and contraceptive decision-making among women: a cross-sectional study from southeastern Iran. PG - 179 LID - 10.1186/s12889-025-25878-0 [doi] LID - 179 AB - BACKGROUND: Women's ability to choose contraceptive methods and shape their reproductive behaviors can significantly improve their reproductive health. However, various factors influence these patterns. This study aimed to examine the socioeconomic determinants affecting contraceptive method choice among women in Zahedan. METHODS: This study included 3,140 women from the Zahedan Cohort Study (October 2015-January 2019). Demographic, fertility, anthropometric, and disease data were collected using a validated questionnaire. Analyses were performed using SPSS version 26. Chi-square tests assessed associations between categorical variables, and variables with p < 0.20 or clinically relevant were entered into a multivariable logistic regression model (effective vs. less-effective contraceptive methods). Adjusted odds ratios (AORs) with 95% confidence intervals (CIs) were reported; p < 0.05 was considered statistically significant. RESULTS: Use of less effective contraception was significantly associated with several factors: it decreased with age (OR = 0.60, p = 0.002) and higher education levels (OR = 1.60, p = 0.001). Underweight individuals were more likely to use less effective methods compared to obese individuals (OR = 1.75, p = 0.007). Higher rates of less effective contraception use were also observed among the very poor (OR = 1.36, p = 0.002) and poor (OR = 1.28, p = 0.01), while women with gestational hypertension (OR = 0.74, p = 0.02) or diabetes (OR = 0.62, p = 0.001) were less likely to use these methods. CONCLUSION: The results of this study indicate that contraceptive method choice is influenced by various factors, including age, body mass index, economic status, and pregnancy complications. These findings underscore the importance of targeted educational interventions and socioeconomic support to encourage the use of safer contraceptive methods among women. CI - (c) 2025. The Author(s). FAU - Shahraki-Sanavi, Fariba AU - Shahraki-Sanavi F AUID- ORCID: 0000-0002-6937-0793 AD - Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. FAU - Moghaddam, Alireza Ansari AU - Moghaddam AA AUID- ORCID: 0000-0002-3267-7193 AD - Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. FAU - Mohammadi, Mahdi AU - Mohammadi M AUID- ORCID: 0000-0001-9616-6125 AD - Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. FAU - Khazaeian, Somayyeh AU - Khazaeian S AUID- ORCID: 0000-0002-5596-4937 AD - Pregnancy Health Research Center, Faculty of Nursing and Midwifery, Zahedan University of Medical Sciences, Zahedan, Iran. khazaeiansomayyeh@gmail.com. LA - eng PT - Journal Article DEP - 20251209 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Adult MH - Iran MH - *Contraception Behavior/statistics & numerical data MH - Young Adult MH - Socioeconomic Factors MH - *Social Determinants of Health/statistics & numerical data MH - *Decision Making MH - *Contraception/statistics & numerical data MH - Surveys and Questionnaires MH - Adolescent MH - Middle Aged PMC - PMC12801653 OTO - NOTNLM OT - Contraceptives OT - Reproductive health OT - Socioeconomic factors OT - Women COIS- Declarations. Ethics approval and consent to participate: The Persian Cohort Study received ethical approval from the Ministry of Health and Zahedan University of Medical Sciences (IDs: IR.ZAUMS.REC.1393-96451 and IR.ZAUMS.REC.1402.111 for the present sub-study). The study was conducted in accordance with the Declaration of Helsinki (1975). Written informed consent was obtained from all participants after explaining the study objectives. Participation was voluntary, confidentiality was ensured, and withdrawal was permitted at any stage. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/09 07:38 MHDA- 2026/01/14 07:06 PMCR- 2025/12/09 CRDT- 2025/12/09 00:25 PHST- 2025/04/27 00:00 [received] PHST- 2025/11/29 00:00 [accepted] PHST- 2026/01/14 07:06 [medline] PHST- 2025/12/09 07:38 [pubmed] PHST- 2025/12/09 00:25 [entrez] PHST- 2025/12/09 00:00 [pmc-release] AID - 10.1186/s12889-025-25878-0 [pii] AID - 25878 [pii] AID - 10.1186/s12889-025-25878-0 [doi] PST - epublish SO - BMC Public Health. 2025 Dec 9;26(1):179. doi: 10.1186/s12889-025-25878-0. PMID- 41361209 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Dec 8 TI - Artificial intelligence model as a tool to predict prediabetes. PG - 43421 LID - 10.1038/s41598-025-23227-0 [doi] LID - 43421 AB - Prediabetes is characterized by elevated blood glucose levels that are higher than normal but below the threshold for diabetes mellitus. While AI models have been used for prediabetes prediction, most rely solely on standard clinical and biochemical markers. This study introduces a novel Pattern Neural Network (PNN) model that uniquely integrates total antioxidant scavenging potential with traditional risk factors, providing new insights into the role of oxidative stress in prediabetes risk stratification among Indian adults. A total of 199 individuals aged 18 to 60 years were recruited and classified based on HbA1c levels into Control (n = 99) and Prediabetes (n = 100) groups. Fourteen input features including age, gender, total antioxidant status, HbA1c, FBG, OGTT, TGL, HDL, LDL, VLDL, TC, WC, Hb, and BMI were used to train a PNN with 14 input nodes, 10 hidden nodes, and one output node. The dataset was randomly divided into training, validation, and testing subsets. Model performance was compared against SVM, KNN, and LR classifiers. Feature importance analysis was conducted to interpret the model's clinical relevance. The PNN model achieved superior validation performance with an accuracy of 98.3%, outperforming SVM (96%), KNN (83%), and LR (71%). Notably, antioxidant scavenging potential and waist circumference emerged as the most influential predictors. The model's output value of 0.8770 (threshold > 0.5) effectively identified individuals at increased risk of developing diabetes. By incorporating oxidative stress markers, this study provides the first AI model in an Indian cohort to link antioxidant status to prediabetes risk. The PNN model demonstrates excellent accuracy and interpretability, offering a clinically actionable tool for early disease detection and personalized intervention. FAU - Yesupatham, Aarthi AU - Yesupatham A AD - Department of Biomedical Sciences, 120TT Biomedical Genetics Research Laboratory, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India. FAU - Das, Raja AU - Das R AD - Department of Mathematics, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu, India. FAU - Bharani, Go AU - Bharani G AD - Department of General Medicine, Mothers Care Diabetes Centre, Vellore, Tamil Nadu, India. FAU - Shaikmeeran, Meera AU - Shaikmeeran M AD - Department of Community Medicine, Government Vellore Medical College, Vellore, Tamil Nadu, India. FAU - Saraswathy, Radha AU - Saraswathy R AD - Department of Biomedical Sciences, 120TT Biomedical Genetics Research Laboratory, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India. radhasaraswathy@vit.ac.in. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251208 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Blood Glucose) RN - 0 (Glycated Hemoglobin) RN - 0 (Biomarkers) SB - IM MH - *Prediabetic State/diagnosis/blood MH - Humans MH - *Artificial Intelligence MH - Adult MH - Female MH - Male MH - Prediction Algorithms MH - Middle Aged MH - Blood Glucose/analysis MH - Adolescent MH - Predictive Learning Models MH - Young Adult MH - Neural Networks, Computer MH - Classification Algorithms MH - Glycated Hemoglobin/analysis MH - Risk Factors MH - Oxidative Stress MH - Biomarkers/blood PMC - PMC12689726 OTO - NOTNLM OT - Artificial intelligence OT - Biochemical parameters OT - K-Nearest neighbors (KNN) OT - Logistic regression OT - Pattern neural network OT - Prediabetes OT - Support vector machines COIS- Declarations. Competing interests: The authors declare no competing interests. Human ethics and consent to participate declarations: This study was conducted in accordance with the ethical principles of the Declaration of Helsinki. The research protocol was approved by respective Institutional Ethics committee for Studies on Human subjects. The study received ethical approval from the Institutional Ethics Committee of Vellore Institute of Technology, Vellore (VIT/IECH/XIV/2023/01), Government Vellore Medical College & Hospital, Vellore (GVMCH) (VMC/III/00001/2023), and the Directorate of Public Health and Preventive Medicine, Chennai (DPH) (DPHPM/DPHSAC/2023/250). All participants were informed about the study's objectives and procedures, and written informed consent was obtained prior to enrolment. EDAT- 2025/12/09 00:32 MHDA- 2026/06/27 12:39 PMCR- 2025/12/08 CRDT- 2025/12/08 23:33 PHST- 2025/07/04 00:00 [received] PHST- 2025/10/06 00:00 [accepted] PHST- 2026/06/27 12:39 [medline] PHST- 2025/12/09 00:32 [pubmed] PHST- 2025/12/08 23:33 [entrez] PHST- 2025/12/08 00:00 [pmc-release] AID - 10.1038/s41598-025-23227-0 [pii] AID - 23227 [pii] AID - 10.1038/s41598-025-23227-0 [doi] PST - epublish SO - Sci Rep. 2025 Dec 8;15(1):43421. doi: 10.1038/s41598-025-23227-0. PMID- 41360460 OWN - NLM STAT- MEDLINE DCOM- 20251208 LR - 20260106 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 12 DP - 2025 Dec 7 TI - Matrix-directed therapy losartan to identify the effect on the bone resorption marker carboxy-terminal crosslink of type I collagen telopeptide (CTX) in older adolescents and adults with osteogenesis imperfecta recruited from secondary care sites: the 'MOI-A' study; a randomised, phase 2/pilot, dose-escalating trial. PG - e107243 LID - 10.1136/bmjopen-2025-107243 [doi] LID - e107243 AB - INTRODUCTION: Osteogenesis imperfecta (OI) is the most common inherited cause of bone fragility (approximately 1 in 16 000). People with OI suffer bone fragility causing fractures, pain and deformity; sarcopenia causing fatigue and poor endurance; aortic root dilatation and hearing loss. No drug currently has market authorisation to treat OI in Europe. Current standard-of-care is multidisciplinary, with pharmacological interventions-primarily bisphosphonates-directed at increasing bone mass; however, such interventions are of equivocal efficacy. The structural damage that can accumulate as a result of repeated fractures over time may not be reversible. The lack of a treatment with clearly defined efficacy in terms of reducing fracture frequency or the sarcopenia, that is increasingly recognised in this condition, leads to the consideration of alternatives based on what is known about the molecular pathophysiology of the condition. For reasons that are currently unclear, transforming growth factor beta (TGFbeta) pathway signalling is increased in OI, and both studies in mouse models and more recently also in humans suggest that reducing TGFbeta pathway signalling could be of benefit in OI. This demonstrator project tests the hypothesis that losartan, an antihypertensive agent known to reduce circulating TGFbeta, will reduce bone turnover and bone loss and have a positive effect on muscle function and quality of life in adults and older adolescents with OI. METHODS AND ANALYSIS: This is a phase 2/pilot, open-label, dose-escalating study. This study aims to identify the effective dose for losartan in this population to inform the design of a pivotal phase III study. The study aims to recruit 30 adolescents and adults aged 16 years and above with OI across secondary care study sites in the UK and Italy. Participants will be recruited from the patient populations attending for treatment of OI at the participating hospital sites or referred by clinicians at the Participant Identification Centres (PIC sites). Participants will be randomised to one of three 'final doses'-25, 50 or 75 mg losartan once daily. All participants will start on 25 mg once daily. Those assigned to higher 'final doses' will increase in 25 mg once daily increments on day 8 and day 15 following safety assessments. The primary outcome measures are to establish the effective dose of losartan in OI patients, based on maximal reduction in the bone resorption marker carboxy-terminal crosslink of type I collagen telopeptide (CTX) over the 24-week period of the study.Secondary outcome measures are to determine the changes in proxy efficacy outcomes for bone (turnover, mass, architecture and strength) using blood tests, high-resolution peripheral quantitative CT (HRpQCT), dual-energy X-ray absorptiometry (DXA) and muscle (strength) using the 'Timed Up and Go' test. In addition, the changes in quality of life, including pain and fatigue, will be evaluated by using a disease-specific tool (OI-QOL) and a validated generic tool (EQ-5D-5L-VAS). ETHICS AND DISSEMINATION: In the UK, the study protocol and amendments have been approved by the London Bridge Research Ethics Committee (REC reference: 23/LO/015) and by the Medicines and Healthcare products Regulatory Agency (MHRA). In Italy, the study protocol and amendments have been approved by the Italian and European ethics and regulatory authorities (Clinical Trials Information System European Union (CTIS EU) portal according to EU Regulation 536/2014). Final version of study protocol: Version 3.2, 05.03.2025. Final results will be disseminated in peer-reviewed journals through local OI, orthopaedic and other relevant clinical networks and at national and international meetings. Sheffield Children's National Health Service Foundation Trust (UK) and Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Ortopedico Rizzoli (Italy) are the joint study sponsors. TRIAL REGISTRATION NUMBER: ISRCTN (ISRCTN13317811). CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Haji Sadeghi, Mahboobeh AU - Haji Sadeghi M AUID- ORCID: 0000-0002-0332-6933 AD - Hull Health Trials Unit, University of Hull, Hull, UK mahboobeh.hajisadeghi@hyms.ac.uk. FAU - Cohen, Judith AU - Cohen J AUID- ORCID: 0000-0002-1538-3521 AD - Hull Health Trials Unit, University of Hull, Hull, UK. FAU - Williams, Bronwen AU - Williams B AD - Hull Health Trials Unit, University of Hull, Hull, UK. FAU - Wilkinson, Amy AU - Wilkinson A AD - Hull Health Trials Unit, University of Hull, Hull, UK. FAU - Sumpter, Sarah AU - Sumpter S AD - Hull Health Trials Unit, University of Hull, Hull, UK. FAU - Simms, Laura AU - Simms L AUID- ORCID: 0009-0009-7950-5178 AD - Hull Health Trials Unit, University of Hull, Hull, UK. FAU - Huang, Chao AU - Huang C AUID- ORCID: 0000-0002-3627-7218 AD - Hull Health Trials Unit, University of Hull, Hull, UK. FAU - Pugh, Keith AU - Pugh K AD - Sheffield Children's NHS Foundation Trust, Sheffield, UK. FAU - Heath, Charlotte AU - Heath C AUID- ORCID: 0009-0001-4819-9114 AD - Sheffield Children's NHS Foundation Trust, Sheffield, UK. FAU - Sangiorgi, Luca AU - Sangiorgi L AD - IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. FAU - Gurioli, Francesca AU - Gurioli F AUID- ORCID: 0009-0006-4284-8618 AD - IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. FAU - Gnoli, Maria AU - Gnoli M AUID- ORCID: 0000-0002-5907-7470 AD - IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. FAU - Moroni, Alice AU - Moroni A AUID- ORCID: 0000-0002-4777-341X AD - IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. FAU - Leopardi, Martina Piccinni AU - Leopardi MP AD - IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. FAU - Del Coco, Clara AU - Del Coco C AD - IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. FAU - Bishop, Nick AU - Bishop N AUID- ORCID: 0000-0001-7263-8546 AD - Sheffield Children's NHS Foundation Trust, Sheffield, UK. AD - The University of Sheffield, Sheffield, UK. LA - eng PT - Journal Article DEP - 20251207 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 RN - JMS50MPO89 (Losartan) RN - 0 (Collagen Type I) RN - 0 (Biomarkers) RN - 0 (collagen type I trimeric cross-linked peptide) RN - 0 (Peptides) RN - 0 (Angiotensin II Type 1 Receptor Blockers) SB - IM MH - Humans MH - *Osteogenesis Imperfecta/drug therapy MH - Adolescent MH - *Losartan/administration & dosage/therapeutic use MH - *Collagen Type I/blood MH - Adult MH - Biomarkers/blood MH - Female MH - Male MH - *Peptides/blood MH - *Bone Resorption/drug therapy MH - Young Adult MH - *Angiotensin II Type 1 Receptor Blockers/administration & dosage/therapeutic use MH - Randomized Controlled Trials as Topic MH - Middle Aged MH - Clinical Trials, Phase II as Topic PMC - PMC12684106 OTO - NOTNLM OT - Adolescent OT - Body Mass Index OT - Bone diseases OT - Musculoskeletal disorders COIS- Competing interests: NJB is global CI for the Ultragenyx/Mereo Biopharma sponsored studies (ORBIT and COSMIC) of setrusumab in children and young adults with OI. All other authors have no competing interest to declare. EDAT- 2025/12/09 00:32 MHDA- 2025/12/09 00:33 PMCR- 2025/12/07 CRDT- 2025/12/08 20:43 PHST- 2025/12/09 00:33 [medline] PHST- 2025/12/09 00:32 [pubmed] PHST- 2025/12/08 20:43 [entrez] PHST- 2025/12/07 00:00 [pmc-release] AID - bmjopen-2025-107243 [pii] AID - 10.1136/bmjopen-2025-107243 [doi] PST - epublish SO - BMJ Open. 2025 Dec 7;15(12):e107243. doi: 10.1136/bmjopen-2025-107243. PMID- 41360203 OWN - NLM STAT- MEDLINE DCOM- 20260130 LR - 20260516 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 219 DP - 2026 Apr 1 TI - Parenting and schema domains as predictors of intuitive and dysregulated eating in emerging adults. PG - 108413 LID - S0195-6663(25)00566-5 [pii] LID - 10.1016/j.appet.2025.108413 [doi] AB - Emerging adulthood is a period when enduring eating patterns consolidate and guide daily food choices. This cross-sectional study examined whether perceived parenting and early maladaptive schema (EMS) domains were associated with intuitive eating, cognitive restraint, emotional eating, and uncontrolled eating among Turkish emerging adults (N = 446). Participants completed validated measures of intuitive and dysregulated eating, maternal/paternal warmth, overprotection, rejection, and five EMS domains. Hierarchical regressions entered demographics and lifestyle factors (Step 1), parenting (Step 2), and EMS domains (Step 3). Exploratory mediation models tested indirect pathways from parenting to eating through EMS domains while adjusting for the same covariates. Men reported higher intuitive eating, whereas women reported greater restraint and emotional eating. Dieting history, higher body mass index, and weight dissatisfaction were consistently associated with lower intuitive eating and higher dysregulated patterns. Parenting contributed modestly to model fit, whereas EMS domains accounted for additional, larger variance. Mediation analyses indicated three indirect pathways: higher maternal warmth related to lower Impaired Autonomy/Performance (IAP), which was associated with higher intuitive eating; higher maternal rejection related to higher IAP, which was associated with greater emotional eating; and higher maternal overprotection related to higher IAP and Other-Directedness, which were associated with greater uncontrolled eating. In final models, maternal warmth related positively to intuitive eating, while IAP-and for uncontrolled eating, Other-Directedness-showed robust links with dysregulated eating. Findings support a layered pattern of associations in which caregiving climates and enduring schemas make separable contributions to appetite-related regulation. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - Kilcik, Deniz Gozde AU - Kilcik DG AD - Graduate Researcher, Psychological Counselor, Turkiye. Electronic address: denizgozdekilcik@gmail.com. FAU - Akfirat, Osman Nejat AU - Akfirat ON AD - Department of Guidance and Psychological Counseling, Kocaeli University, Turkiye. Electronic address: nejat.akfirat@kocaeli.edu.tr. LA - eng PT - Journal Article DEP - 20251206 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - Male MH - *Parenting/psychology MH - Cross-Sectional Studies MH - Young Adult MH - *Feeding Behavior/psychology MH - Adult MH - Adolescent MH - Intuition MH - Body Mass Index MH - Emotions MH - *Feeding and Eating Disorders/psychology MH - *Eating/psychology OTO - NOTNLM OT - Cognitive restraint OT - Early maladaptive schemas OT - Emotional eating OT - Intuitive eating OT - Parenting OT - Uncontrolled eating COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/12/09 00:31 MHDA- 2026/01/31 00:29 CRDT- 2025/12/08 19:29 PHST- 2025/08/20 00:00 [received] PHST- 2025/11/19 00:00 [revised] PHST- 2025/12/05 00:00 [accepted] PHST- 2026/01/31 00:29 [medline] PHST- 2025/12/09 00:31 [pubmed] PHST- 2025/12/08 19:29 [entrez] AID - S0195-6663(25)00566-5 [pii] AID - 10.1016/j.appet.2025.108413 [doi] PST - ppublish SO - Appetite. 2026 Apr 1;219:108413. doi: 10.1016/j.appet.2025.108413. Epub 2025 Dec 6. PMID- 41358232 OWN - NLM STAT- MEDLINE DCOM- 20251208 LR - 20251210 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Development and interpretation of a machine learning model for predicting body mass index in Chinese adolescents: a prospective cohort study. PG - 1657551 LID - 10.3389/fpubh.2025.1657551 [doi] LID - 1657551 AB - PURPOSES: This study aimed to develop a machine learning model to predict body mass index (BMI) in adolescents based on readily accessible daily information and to investigate the influence of modifiable factors on BMI changes through model interpretation techniques. METHODS: This study is a one-year prospective cohort study. Baseline data were collected through anthropometric measurements and questionnaires, and BMI were reassessed after 1 year. Six machine learning models were developed to predict BMI. Nested cross-validation (CV) was used for hyperparameter tuning and performance estimation. Predictors were prescreened on the inner-training folds of the nested CV using univariable analyses. Model performance was evaluated using Root Mean Squared Error (RMSE), Mean Squared Error (MSE), Mean Absolute Error (MAE), and coefficient of determination (R(2)). SHapley Additive exPlanations (SHAP) was used for global and local interpretations of the models. RESULTS: The mean BMI of the 1,827 students included in the final analysis increased from 21.18 +/- 3.63 kg/m(2) at baseline to 21.54 +/- 3.59 kg/m(2) after 1 year, with an average change of 0.36 +/- 1.40 kg/m(2). The CatBoost (CB) model demonstrated the best predictive performance. After calibration, it achieved an RMSE of 1.200 [95% confidence interval (CI): 1.101-1.303], MSE of 1.440 (95% CI: 1.211-1.697), MAE of 0.895 (95% CI: 0.818-0.981) and R(2) of 0.902 (95% CI: 0.882-0.918). In the SHAP analysis, the top 5 modifiable features at the population level were: level of health literacy, recognize self-weight status correctly, sedentariness duration on weekends, participation in professional sports training, frequency of staying up late. CONCLUSION: This study developed a BMI prediction model for adolescents using readily accessible daily information. The model accurately predicts BMI values 1 year later and provides both population-level and individual-level interpretability. Compared to existing studies, it offers key advantages, including independence from complex clinical data, the ability to predict continuous BMI values, and strong model interpretability. Our findings provide a promising research tool for screening high-risk adolescents, informing public health prevention and intervention strategies, and supporting personalized clinical interventions. CI - Copyright (c) 2025 Zhang, Peng, Sun, Zhang, Sun and Huang. FAU - Zhang, Zikang AU - Zhang Z AD - Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, China. AD - University of Science and Technology of China, Hefei, Anhui, China. FAU - Peng, Wei AU - Peng W AD - Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, China. AD - CAS Hefei Institute of Technology Innovation, Hefei, Anhui, China. FAU - Sun, Shaoming AU - Sun S AD - Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, China. AD - CAS Hefei Institute of Technology Innovation, Hefei, Anhui, China. FAU - Zhang, Fangwen AU - Zhang F AD - Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, China. AD - University of Science and Technology of China, Hefei, Anhui, China. FAU - Sun, Yining AU - Sun Y AD - Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, China. FAU - Huang, Lei AU - Huang L AD - Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, China. AD - University of Science and Technology of China, Hefei, Anhui, China. LA - eng PT - Journal Article DEP - 20251120 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - Chinese people SB - IM MH - Humans MH - *Body Mass Index MH - Adolescent MH - Prospective Studies MH - Female MH - Male MH - *Machine Learning MH - China MH - Surveys and Questionnaires MH - East Asian People PMC - PMC12675250 OTO - NOTNLM OT - BMI OT - daily information OT - machine learning OT - model interpretation OT - modifiable factors OT - prediction model COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/08 13:20 MHDA- 2025/12/08 13:21 PMCR- 2025/11/20 CRDT- 2025/12/08 06:29 PHST- 2025/07/01 00:00 [received] PHST- 2025/10/26 00:00 [revised] PHST- 2025/11/10 00:00 [accepted] PHST- 2025/12/08 13:21 [medline] PHST- 2025/12/08 13:20 [pubmed] PHST- 2025/12/08 06:29 [entrez] PHST- 2025/11/20 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1657551 [doi] PST - epublish SO - Front Public Health. 2025 Nov 20;13:1657551. doi: 10.3389/fpubh.2025.1657551. eCollection 2025. PMID- 41358216 OWN - NLM STAT- MEDLINE DCOM- 20251208 LR - 20251210 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Random forest-based identification and ranking of predictive factors for physical activity in Chinese college students. PG - 1699606 LID - 10.3389/fpubh.2025.1699606 [doi] LID - 1699606 AB - OBJECTIVE: To explore the key predictors of physical activity (PA) levels of Chinese university students, and to analyse the predictive roles of different variables and their relative importance by means of the Random Forest (RF) algorithm. METHODS: A cross-sectional study was conducted using a stratified whole-group sampling method, covering 17 provinces of the country and collecting 10,182 valid questionnaires. Assessment of PA levels using the Physical Activity Rating Scale-3 (PARS-3) divides participants into attainment and non-attainment groups. The independent variables encompass the individual and interpersonal organisational levels of the socio-ecological model (SEM), comprising a total of 39 variables. These variables include demographic characteristics, psycho-behavioural factors, and social support, which were measured using several standardised scales. Feature importance analysis was performed using the Random Forest algorithm, and the model parameters were optimised with a grid search and 5-fold cross-validation to identify the most significant factors predicting PA. RESULTS: The RF model had an accuracy of 0.704 and an AUC value of 0.762. Characteristic importance analysis revealed that exercise adherence (exercise behaviour), sex, exercise adherence (effort investment), mastery of sports skills, exercise motivation (ability), alcohol consumption level, exercise adherence [emotional experience, exercise motivation (social), and exercise motivation (fun) ranked as the top nine predictive factors]. Specifically, all sub-dimensions of exercise adherence (exercise behaviour) positively predict PA (SHAP values > 0); sex, males are more likely than females to meet the standard group criteria (OR > 1, p < 0.001); mastery of sports skills correlates positively with PA levels; and among alcohol consumption level, 'occasional drinking' shows a negative correlation with the standard attainment rate (p < 0.001). CONCLUSION: Exercise adherence, sex, mastery of sports skills, and alcohol consumption level are significant factors predicting PA levels among Chinese university students. Recommendations for promoting PA include enhancing the "emotional value" and social attributes of exercise, addressing female students' willingness to participate, and improving physical capabilities through skills training to effectively elevate activity levels. CI - Copyright (c) 2025 Zhang, Lou, Liu and Li. FAU - Zhang, Ding-You AU - Zhang DY AD - Institute of Sports Science, Nantong University, Nantong, China. FAU - Lou, Hu AU - Lou H AD - Institute of Sports Science, Nantong University, Nantong, China. FAU - Liu, Jun AU - Liu J AD - Institute of Sports Science, Nantong University, Nantong, China. FAU - Li, Bo AU - Li B AD - Institute of Sports Science, Nantong University, Nantong, China. LA - eng PT - Journal Article DEP - 20251120 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Female MH - Male MH - *Students/statistics & numerical data/psychology MH - Cross-Sectional Studies MH - *Exercise/psychology MH - China MH - Universities MH - Young Adult MH - Surveys and Questionnaires MH - Adult MH - Motivation MH - Adolescent MH - Algorithms MH - Social Support MH - Random Forest PMC - PMC12675355 OTO - NOTNLM OT - machine learning OT - physical activity OT - random forest OT - socio-ecological model OT - university students COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/08 13:19 MHDA- 2025/12/08 13:20 PMCR- 2025/11/20 CRDT- 2025/12/08 06:29 PHST- 2025/09/11 00:00 [received] PHST- 2025/11/06 00:00 [revised] PHST- 2025/11/07 00:00 [accepted] PHST- 2025/12/08 13:20 [medline] PHST- 2025/12/08 13:19 [pubmed] PHST- 2025/12/08 06:29 [entrez] PHST- 2025/11/20 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1699606 [doi] PST - epublish SO - Front Public Health. 2025 Nov 20;13:1699606. doi: 10.3389/fpubh.2025.1699606. eCollection 2025. PMID- 41355796 OWN - NLM STAT- MEDLINE DCOM- 20251208 LR - 20260717 IS - 2379-3708 (Electronic) IS - 2379-3708 (Linking) VI - 10 IP - 23 DP - 2025 Dec 8 TI - A transcriptomic signature that predicts prehypertension in adolescence and higher systolic blood pressure in childhood. LID - 10.1172/jci.insight.192837 [doi] LID - e192837 AB - BACKGROUNDSuboptimal fetal growth (SFG), being born small for gestational age (SGA), and catch-up (CU) growth are, individually and together, linked to cardiometabolic risks. However, not all develop adverse outcomes. This study aimed to validate a transcriptomic signature to identify individuals at greatest cardiometabolic risk.METHODSUsing National Heart, Lung and Blood Institute (NHLBI) criteria to define cardiometabolic risk, healthy and prehypertensive 17-year-olds were identified in the Avon Longitudinal Study of Parents and Children (ALSPAC) (UK) childhood cohort. Epigenomic and transcriptomic differences were analyzed. A hypergraph identified functionally related genes, which were used in random forest classification to predict prehypertensive phenotypes. The BabyGRO (UK) cohort included 80 children aged 3-7 years, born at term following pregnancies with SFG risks. Anthropometric and cardiometabolic markers and transcriptomic profiles were collected, fetal and childhood weight trajectories and their relationship to cardiometabolic markers were assessed, and transcriptome was used for prediction.RESULTSIndividuals with CU-SGA in ALSPAC were 1.6 times more likely than all others to be prehypertensive at 17 years (P < 1 x 10-5). A 42-gene hypergraph cluster was highly predictive of prehypertension (AUC 0.984, error rate 5.4%). In BabyGRO, 20 of these genes accurately predicted higher systolic blood pressure (AUC 0.971, error rate 3.6%). This transcriptomic signature could help identify children with adverse pre- and postnatal growth who may develop prehypertension.CONCLUSIONA blood transcriptomic signature exists in childhood which distinguishes those at risk of adult cardiometabolic disease among children with adverse pre- and postnatal growth.TRIAL REGISTRATIONRegional ethics committee reference 17/NW/0153, IRAS project ID 187679.FUNDINGCentre grant to the Maternal and Fetal Health Research Centre by Tommy's The Pregnancy and Baby Charity, Child Growth Foundation, European Research Council funding as part of the Health and Environment-wide Associations based on Large Population Surveys (HEALS) study. FAU - Perchard, Reena AU - Perchard R AD - Division of Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, United Kingdom. AD - Manchester University NHS Foundation Trust, Manchester, United Kingdom. FAU - Garner, Terence AU - Garner T AD - Division of Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, United Kingdom. FAU - Murray, Philip G AU - Murray PG AD - Manchester University NHS Foundation Trust, Manchester, United Kingdom. FAU - Roslan, Amirul AU - Roslan A AD - Division of Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, United Kingdom. FAU - Higgins, Lucy E AU - Higgins LE AD - Division of Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, United Kingdom. AD - Manchester University NHS Foundation Trust, Manchester, United Kingdom. FAU - Johnstone, Edward D AU - Johnstone ED AD - Division of Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, United Kingdom. AD - Manchester University NHS Foundation Trust, Manchester, United Kingdom. FAU - Stevens, Adam AU - Stevens A AD - Division of Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, United Kingdom. FAU - Clayton, Peter E AU - Clayton PE AD - Division of Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, United Kingdom. LA - eng PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20251208 PL - United States TA - JCI Insight JT - JCI insight JID - 101676073 SB - IM MH - Humans MH - *Prehypertension/genetics/diagnosis/epidemiology MH - Female MH - Male MH - Adolescent MH - Child MH - *Transcriptome MH - Child, Preschool MH - *Blood Pressure/genetics MH - Longitudinal Studies MH - Infant, Small for Gestational Age MH - Fetal Development/genetics MH - Pregnancy PMC - PMC12890495 OTO - NOTNLM OT - Cardiology OT - Hypertension OT - Preventative medicine OT - Public Health EDAT- 2025/12/08 13:19 MHDA- 2025/12/08 13:20 PMCR- 2025/12/08 CRDT- 2025/12/08 06:03 PHST- 2025/03/03 00:00 [received] PHST- 2025/10/22 00:00 [accepted] PHST- 2025/12/08 13:20 [medline] PHST- 2025/12/08 13:19 [pubmed] PHST- 2025/12/08 06:03 [entrez] PHST- 2025/12/08 00:00 [pmc-release] AID - 192837 [pii] AID - 10.1172/jci.insight.192837 [doi] PST - epublish SO - JCI Insight. 2025 Dec 8;10(23):e192837. doi: 10.1172/jci.insight.192837. eCollection 2025 Dec 8. PMID- 41353659 OWN - NLM STAT- MEDLINE DCOM- 20251229 LR - 20260516 IS - 1532-7914 (Electronic) IS - 0163-5581 (Linking) VI - 78 IP - 2 DP - 2026 TI - Adherence to Oral Nutritional Support and Its Effect on Nutritional Status in Pediatric Oncology Patients. PG - 145-157 LID - 10.1080/01635581.2025.2584473 [doi] AB - Children with cancer frequently suffer from malnutrition caused by their disease and treatments. This study examines the rates of malnutrition, compliance with nutritional therapy, and its impact on nutritional status in pediatric cancer patients. This multicenter cross-sectional study was conducted between 2021 and 2023 at 12 pediatric hematology and oncology clinics. This study included 385 patients (aged 0.3-18 years) with leukemia-lymphoma and solid tumors that are currently on or had newly started oral nutritional supplement (ONS) treatment. Anthropometric measurements, mid-upper-arm-circumference (MUAC), body mass index (BMI), weight-for-age (WFA), were collected, and malnutrition risk was evaluated by the nutrition screening tool for childhood cancer (SCAN). Baseline WFA-based malnutrition was 31.0%, increasing to 38.5%, while SCAN>/=3 was 83.8% decreasing to 72.4% at the sixth month. Malnutrition risk was more common in sarcoma and central nervous system tumor patients. ONS adherence decreased across all cancer types during the follow-up period. Adherent patients demonstrated higher BMI scores during the study period and MUAC z-scores in the last 2 months compared to the non-adherent group (P < 0.04). Our study demonstrates that the use of validated nutrition screening tools, together with adherence strategies, can lead to increased weight-for-age and lower malnutrition risk screening scores. FAU - Kantar, Mehmet AU - Kantar M AUID- ORCID: 0000-0002-1669-4321 AD - Ege University, School of Medicine, Division of Pediatric Oncology, Bornova, Izmir, Turkey. FAU - Bicakli, Derya Hopanci AU - Bicakli DH AD - Ege University, School of Medicine, Division of Pediatric Oncology, Bornova, Izmir, Turkey. FAU - Ozkan, Ayse AU - Ozkan A AD - Cukurova University, School of Medicine, Division of Pediatric Oncology, Adana, Turkey. FAU - Ilhan, Inci AU - Ilhan I AD - Bilkent City Hospital, Pediatric Oncology Unit, Ankara, Turkey. FAU - Tacyildiz, Nurdan AU - Tacyildiz N AD - Ankara University, School of Medicine, Division of Pediatric Oncology, Ankara, Turkey. FAU - Kebudi, Rejin AU - Kebudi R AD - Istanbul University, Institute of Oncology, Division of Pediatric Oncology, Istanbul, Turkey. FAU - Eker, Nursah AU - Eker N AD - Marmara University, School of Medicine, Division of Pediatric Oncology, Istanbul, Turkey. FAU - Sivis, Zuhal AU - Sivis Z AD - Izmir City Hospital, Pediatric Oncology Unit, Izmir, Turkey. FAU - Demirsoy, Ugur AU - Demirsoy U AD - Kocaeli University, School of Medicine, Division of Pediatric Oncology, Kocaeli, Turkey. FAU - Beker, Bahar AU - Beker B AD - Sisli Hamidiye Etfal Training and Research Hospital, Pediatric Oncology Unit, Istanbul, Turkey. FAU - Yesil, Sule AU - Yesil S AD - Etlik City Hospital, Pediatric Hematology and Oncology Unit, Ankara, Turkey. FAU - Varan, Ali AU - Varan A AD - Hacettepe University, School of Medicine, Division of Pediatric Oncology, Ankara, Turkey. FAU - Demirag, Bengu AU - Demirag B AD - Behcet Uz Children's Hospital, Pediatric Oncology Unit, Izmir, Turkey. FAU - Bayram, Ibrahim AU - Bayram I AD - Cukurova University, School of Medicine, Division of Pediatric Oncology, Adana, Turkey. FAU - Ozyoruk, Derya AU - Ozyoruk D AD - Bilkent City Hospital, Pediatric Oncology Unit, Ankara, Turkey. FAU - Ataseven, Eda AU - Ataseven E AD - Ege University, School of Medicine, Division of Pediatric Oncology, Bornova, Izmir, Turkey. FAU - Incesoy, Sonay AU - Incesoy S AD - Ankara University, School of Medicine, Division of Pediatric Oncology, Ankara, Turkey. FAU - Buyukkapu, Sema AU - Buyukkapu S AD - Istanbul University, Institute of Oncology, Division of Pediatric Oncology, Istanbul, Turkey. FAU - Tufan, Burcu AU - Tufan B AD - Marmara University, School of Medicine, Division of Pediatric Oncology, Istanbul, Turkey. FAU - Kizmazoglu, Deniz AU - Kizmazoglu D AD - Izmir City Hospital, Pediatric Oncology Unit, Izmir, Turkey. FAU - Vural, Sema AU - Vural S AD - Sisli Hamidiye Etfal Training and Research Hospital, Pediatric Oncology Unit, Istanbul, Turkey. FAU - Kurucu, Burcak AU - Kurucu B AD - Etlik City Hospital, Pediatric Hematology and Oncology Unit, Ankara, Turkey. FAU - Coskun, Cagri AU - Coskun C AD - Hacettepe University, School of Medicine, Division of Pediatric Oncology, Ankara, Turkey. FAU - Sursal, Alihan AU - Sursal A AD - Neuroscience, Bahcesehir University Faculty of Medicine, Istanbul, Turkey. FAU - Ozkan, Emre AU - Ozkan E AD - Medical Affairs, Nutricia, Specialized Nutrition, Istanbul, Turkey. FAU - Ozdener, Fatih AU - Ozdener F AUID- ORCID: 0000-0002-0163-318X AD - Department of Pharmacology, Bahcesehir University Faculty of Medicine, Istanbul, Turkey. LA - eng PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20251207 PL - United States TA - Nutr Cancer JT - Nutrition and cancer JID - 7905040 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - *Nutritional Status MH - Adolescent MH - Child, Preschool MH - Cross-Sectional Studies MH - *Neoplasms/complications/therapy MH - Infant MH - *Malnutrition/etiology/epidemiology MH - *Patient Compliance/statistics & numerical data MH - *Nutritional Support/methods MH - Body Mass Index MH - Nutrition Assessment EDAT- 2025/12/07 20:35 MHDA- 2025/12/30 00:30 CRDT- 2025/12/07 10:43 PHST- 2025/12/30 00:30 [medline] PHST- 2025/12/07 20:35 [pubmed] PHST- 2025/12/07 10:43 [entrez] AID - 10.1080/01635581.2025.2584473 [doi] PST - ppublish SO - Nutr Cancer. 2026;78(2):145-157. doi: 10.1080/01635581.2025.2584473. Epub 2025 Dec 7. PMID- 41351293 OWN - NLM STAT- MEDLINE DCOM- 20260609 LR - 20260720 IS - 1469-8749 (Electronic) IS - 0012-1622 (Linking) VI - 68 IP - 7 DP - 2026 Jul TI - The Children's Eating and Drinking Activity Scale: Interrater reliability, concurrent validity, and responsiveness. PG - 952-958 LID - 10.1111/dmcn.70110 [doi] AB - AIM: To assess the interrater reliability, concurrent validity, and responsiveness of the Children's Eating and Drinking Activity Scale (CEDAS). METHOD: Interrater reliability was assessed using an online questionnaire completed by speech and language therapists working in hospital and community settings. Participants (n = 39) applied CEDAS to 12 vignettes. Interrater reliability was calculated using Krippendorff's alpha (alpha). Additionally, CEDAS was applied retrospectively to consecutive speech and language therapy referrals at a single hospital (n = 85, median age 11 years 2 months, range 1 week-17 years 1 month). Responsiveness was assessed by comparing median CEDAS scores at referral, after initial speech and language therapy assessment, and at discharge. The Functional Status Scale (FSS) feeding domain was used to evaluate concurrent validity. RESULTS: Interrater reliability was excellent (Krippendorff's alpha = 0.927). CEDAS was responsive to change, with expected score increases seen between referral and discharge (Z = -4.37, p < 0.001), and initial assessment and discharge (Z = -3.23, p < 0.001). Strong concurrent validity was established with the FSS (r(s) = -0.77 to -0.99, p < 0.003). INTERPRETATION: CEDAS demonstrates excellent interrater reliability across clinical settings. It is a responsive tool with established construct validity when used in an acute hospital setting. CI - (c) 2025 The Author(s). Developmental Medicine & Child Neurology published by John Wiley & Sons Ltd on behalf of Mac Keith Press. FAU - Mantaring, Ericka Joinelle AU - Mantaring EJ AD - Department of Language and Cognition, University College London, London, UK. FAU - Wong, Sheung Yu Sylfiana AU - Wong SYS AD - Department of Language and Cognition, University College London, London, UK. FAU - McInerney, Michelle AU - McInerney M AD - Department of Language and Cognition, University College London, London, UK. FAU - Thorpe, Vicky AU - Thorpe V AD - Department of Speech and Language Therapy, Great Ormond Street Hospital for Children, London, UK. FAU - Stewart, Alexandra AU - Stewart A AUID- ORCID: 0000-0003-2170-6769 AD - Department of Language and Cognition, University College London, London, UK. AD - Department of Speech and Language Therapy, Great Ormond Street Hospital for Children, London, UK. LA - eng GR - Health Education England and the National Institute for Health and Care Research (NIHR)/ PT - Journal Article DEP - 20251205 PL - England TA - Dev Med Child Neurol JT - Developmental medicine and child neurology JID - 0006761 SB - IM MH - Humans MH - Reproducibility of Results MH - Child, Preschool MH - Child MH - Female MH - Male MH - Adolescent MH - Infant MH - Observer Variation MH - Surveys and Questionnaires MH - Retrospective Studies MH - Infant, Newborn MH - Psychometrics MH - *Feeding Behavior/physiology EDAT- 2025/12/06 06:33 MHDA- 2026/06/09 06:36 CRDT- 2025/12/06 02:14 PHST- 2025/10/08 00:00 [revised] PHST- 2025/05/22 00:00 [received] PHST- 2025/10/15 00:00 [accepted] PHST- 2026/06/09 06:36 [medline] PHST- 2025/12/06 06:33 [pubmed] PHST- 2025/12/06 02:14 [entrez] AID - 10.1111/dmcn.70110 [doi] PST - ppublish SO - Dev Med Child Neurol. 2026 Jul;68(7):952-958. doi: 10.1111/dmcn.70110. Epub 2025 Dec 5. PMID- 41348802 OWN - NLM STAT- MEDLINE DCOM- 20251205 LR - 20251208 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 12 DP - 2025 TI - The triple burden of malnutrition among adolescents in Dar es Salaam, Tanzania: The role of gender, household environment, and food insecurity. PG - e0337102 LID - 10.1371/journal.pone.0337102 [doi] LID - e0337102 AB - BACKGROUND: Adolescence is a critical growth period with increased nutritional needs that can put adolescents at risk for the triple burden of malnutrition, which can impair brain development, reduce functional capacity, and heighten the risk of non-communicable diseases. Despite this, there is limited data on factors associated with adolescent malnutrition in Dar es Salaam. This study aimed to determine the prevalence and associated factors for anaemia, stunting, underweight and overweight/obesity among adolescents in Dar es Salaam. METHODS: A cross-sectional study was conducted among 507 adolescents aged 12-19 in Dar es Salaam, using multistage cluster sampling. Data was collected using a pre-validated structured questionnaire through an Open Data Kit, while anthropometric measurements were measured using a digital weighing scale and stadiometer. Hemocue machines were utilised to measure anaemia through capillary blood samples. Data analysis, including descriptive statistics and modified Poisson regression, was performed using Stata v18 to identify factors associated with malnutrition. RESULTS: Overweight affected 16%, anaemia 39%, stunting 23% and thinness 12% of all adolescents. Food insecurity affected 69% of the households and was associated with a lower overweight risk (Crude Prevalence Ratio (CPR) 0.51, 95% CI: 0.34-0.75, p = 0.001) and a higher risk for thinness (CPR 2.10, 95% CI: 1.13, 3.91, p = 0.019). After controlling for other explanatory variables, adolescents from households with unimproved toilet facilities had a higher risk of anaemia (APR 1.51, 95% CI: 1.16-1.95, p = 0.002). Girls had a lower risk of stunting (APR 0.63, 95%, CI: 0.45-0.88, p = 0.006) and thinness (APR 0.29, 95%, CI: 0.16-0.54, p < 0.001) but a higher risk for overweight (APR 2.62, 95%, CI: 1.56-4.43, p < 0.001) compared to boys. CONCLUSION: Adolescents in Dar es Salaam experience high rates of malnutrition. Food insecurity, poor sanitation, and gender-specific factors contribute significantly to these outcomes. Integrated interventions are essential to address these interlinked determinants of malnutrition in this vulnerable group. CI - Copyright: (c) 2025 Kimaryo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Kimaryo, Christina AU - Kimaryo C AUID- ORCID: 0009-0007-8025-7226 AD - Centre for International Health, University of Bergen, Bergen, Norway. FAU - Efraim, Josephine AU - Efraim J AD - Centre for International Health, University of Bergen, Bergen, Norway. FAU - Njenge, Nancy AU - Njenge N AD - Centre for International Health, University of Bergen, Bergen, Norway. FAU - Sunguya, Bruno AU - Sunguya B AD - Department of Community Health, School of Public Health and Social Sciences, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Haskins, Lyn AU - Haskins L AD - Centre for Rural Health, University of KwaZulu-Natal, Durban, South Africa. FAU - Hatloy, Anne AU - Hatloy A AUID- ORCID: 0000-0002-3668-3216 AD - Centre for International Health, University of Bergen, Bergen, Norway. AD - Fafo Institute for Labour and Social Science, Oslo, Norway. FAU - Horwood, Christiane AU - Horwood C AD - Centre for Rural Health, University of KwaZulu-Natal, Durban, South Africa. LA - eng PT - Journal Article DEP - 20251205 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Adolescent MH - Tanzania/epidemiology MH - Male MH - Female MH - *Malnutrition/epidemiology MH - Cross-Sectional Studies MH - Child MH - *Food Insecurity MH - Prevalence MH - Thinness/epidemiology MH - Anemia/epidemiology MH - Overweight/epidemiology MH - Family Characteristics MH - Young Adult MH - Growth Disorders/epidemiology MH - Sex Factors PMC - PMC12680259 COIS- The authors have declared that no competing interests exist. EDAT- 2025/12/05 19:00 MHDA- 2025/12/05 19:01 PMCR- 2025/12/05 CRDT- 2025/12/05 13:46 PHST- 2025/03/13 00:00 [received] PHST- 2025/11/04 00:00 [accepted] PHST- 2025/12/05 19:01 [medline] PHST- 2025/12/05 19:00 [pubmed] PHST- 2025/12/05 13:46 [entrez] PHST- 2025/12/05 00:00 [pmc-release] AID - PONE-D-25-13116 [pii] AID - 10.1371/journal.pone.0337102 [doi] PST - epublish SO - PLoS One. 2025 Dec 5;20(12):e0337102. doi: 10.1371/journal.pone.0337102. eCollection 2025. PMID- 41346195 OWN - NLM STAT- MEDLINE DCOM- 20260521 LR - 20260813 IS - 1941-2452 (Electronic) IS - 0884-5336 (Print) IS - 0884-5336 (Linking) VI - 41 IP - 3 DP - 2026 Jun TI - Development and validation of a nutrition risk screening for patients with childhood cancer in Brazil (NUTRICCAN). PG - 768-778 LID - 10.1002/ncp.70076 [doi] AB - BACKGROUND: Diagnosing malnutrition in patients with pediatric cancer is challenging because tumor masses can interfere with anthropometric measurements. STRONGkids considers cancer a general risk factor, whereas Screening Tool for Childhood Cancer (SCAN) classifies patients as at risk or not, potentially missing those who need nutrition monitoring. This study describes development and validation of a new nutrition risk screening tool for childhood cancer in Brazil. METHODS: Nutrition Risk Screening for Childhood Cancer (NUTRICCAN) underwent online expert content validation. Twelve nutritionists applied it to oncology inpatients (0-19 years old) at the Pediatric Oncology Institute at Federal University of Sao Paulo from June to August 2024. Nutrition risk was assessed using NUTRICCAN, STRONGkids, and SCAN. Logistic regression identified screening variables associated with malnutrition (body mass index-for-age z score < -2, mid-upper arm circumference [MUAC] <5(th) percentile, calf circumference below cutoff, or met any of the criteria for malnutrition). Receiver operating characteristic analysis determined cutoff scores, and sensitivity/specificity analyses allowed comparisons among instruments. RESULTS: Patients not receiving intensive care were almost three times more likely to have an inadequate MUAC (odds ratio [OR], 4.505; 95% confidence interval [CI], 1.446-14.033; P = 0.009). Low socioeconomic status or caregiver education increased the risk of malnutrition (OR, 2.845; 95% CI, 1.070-7.566; P = 0.036). Dietitians' subjective assessments were associated with a fourfold increased risk of malnutrition. NUTRICCAN was 70% accurate (area under the curve, 0.701; 95% CI, 0.617-0.785), outperforming the other tools. CONCLUSION: NUTRICCAN better stratifies nutritional risk, considering clinical and socioeconomic factors, and may allow for more targeted interventions, especially in resource-limited settings. CI - (c) 2025 The Author(s). Nutrition in Clinical Practice published by Wiley Periodicals LLC on behalf of American Society for Parenteral and Enteral Nutrition. FAU - Marcon, Cristiane Ferreira AU - Marcon CF AUID- ORCID: 0000-0002-3819-9081 AD - Postgraduate Program in Nutrition, Federal University of Sao Paulo, Sao Paulo, Brazil. FAU - Santos, Carolina Araujo Dos AU - Santos CAD AD - Department of Nutrition and Health, Federal University of Vicosa, Vicosa, Minas Gerais, Brazil. FAU - Oliveira, Fernanda Luisa Ceragioli AU - Oliveira FLC AD - Postgraduate Program in Nutrition, Federal University of Sao Paulo, Sao Paulo, Brazil. AD - Department of Pediatrics, Discipline of Pediatric Nutrology, Escola Paulista de Medicina Federal, University of Sao Paulo, Sao Paulo, Brazil. LA - eng GR - None/ PT - Journal Article PT - Validation Study DEP - 20251204 PL - United States TA - Nutr Clin Pract JT - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JID - 8606733 SB - IM MH - Humans MH - Brazil/epidemiology MH - Child MH - Child, Preschool MH - *Nutrition Assessment MH - Adolescent MH - Female MH - Male MH - Infant MH - *Malnutrition/diagnosis/etiology MH - *Neoplasms/complications MH - Young Adult MH - Risk Factors MH - Nutritional Status MH - *Mass Screening/methods MH - Risk Assessment/methods MH - ROC Curve MH - Infant, Newborn MH - Sensitivity and Specificity MH - Logistic Models MH - Reproducibility of Results PMC - PMC13193373 OTO - NOTNLM OT - life cycle OT - nutrition OT - nutrition assessment OT - oncology OT - pediatrics OT - research and diseases COIS- None declared. EDAT- 2025/12/05 06:27 MHDA- 2026/05/21 12:38 PMCR- 2026/05/21 CRDT- 2025/12/05 02:32 PHST- 2025/10/29 00:00 [revised] PHST- 2025/03/16 00:00 [received] PHST- 2025/11/05 00:00 [accepted] PHST- 2026/05/21 12:38 [medline] PHST- 2025/12/05 06:27 [pubmed] PHST- 2025/12/05 02:32 [entrez] PHST- 2026/05/21 00:00 [pmc-release] AID - NCP70076 [pii] AID - 10.1002/ncp.70076 [doi] PST - ppublish SO - Nutr Clin Pract. 2026 Jun;41(3):768-778. doi: 10.1002/ncp.70076. Epub 2025 Dec 4. PMID- 41344702 OWN - NLM STAT- MEDLINE DCOM- 20251204 LR - 20260106 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 12 DP - 2025 Dec 4 TI - Screen time and sleep problems in South Indian preschoolers: a community-based cross-sectional study. PG - e109376 LID - 10.1136/bmjopen-2025-109376 [doi] LID - e109376 AB - OBJECTIVES: To estimate the prevalence of sleep problems among children aged 2-5 years residing in South India, assess its association with screen time and identify a predictive screen time threshold. DESIGN: Population-based cross-sectional study. SETTING: Field practice areas in rural and urban centres of a medical college in South India. PARTICIPANTS: In total, 523 children aged 2-5 years were selected by simple random sampling. PRIMARY OUTCOME MEASURES: Sleep problems were assessed using the validated bedtime problems, excessive daytime sleepiness, awakenings during the night, regularity of sleep and snoring sleep screening tool. Sociodemographic and behavioural factors, including screen time, were also examined. The optimal predictive screen time cut-off was identified using receiver operating characteristic (ROC) analysis. RESULTS: Sleep disturbances were reported in 39.6% of children (95% CI 35.5% to 43.8%). The most common sleep problems were irregular sleep (22.2%), bedtime resistance (20.8%) and night awakening (19.9%). Multivariate logistic regression showed strong associations between sleep problems and screen use in bed (adjusted OR (AOR) = 3.8; 95% CI 2.4 to 6.1), excess screen time (AOR=3.3; 95% CI 1.8 to 6), smaller family size (AOR=3.1; 95% CI 1.5 to 6.1), reduced physical activity (AOR=2.6; 95% CI 1.6 to 4.2), shorter birth spacing (AOR=1.8; 95% CI 1.1 to 2.8), lower socioeconomic status (AOR=1.8; 95% CI 1.2 to 2.8) and maternal screen time>2 hours/day (AOR=1.6; 95% CI 1.04 to 2.6). ROC analysis identified >/=2.4 hours per day of screen time as the optimal threshold for predicting sleep problems (area under the curve=0.800; sensitivity, 73.9% and specificity, 77.2%). CONCLUSION: In this large population-based study, two of the five preschool children experienced sleep problems, with excess screen time, particularly screen use in bed, being the key contributing factor. This is one of the few Indian studies to establish an ROC-derived screen time threshold for identifying sleep problems. These findings can guide targeted parental advice and early preventive strategies to promote healthy sleep in preschool children. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Govindarajan Venguidesvarane, Akila AU - Govindarajan Venguidesvarane A AUID- ORCID: 0000-0002-4387-8564 AD - Department of Community Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, India. FAU - Varadarajan, Samya AU - Varadarajan S AUID- ORCID: 0000-0002-6396-5593 AD - Department of Community Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, India vsamya@gmail.com. FAU - Rajamohan, Muthukumar AU - Rajamohan M AUID- ORCID: 0000-0003-4029-558X AD - Department of Community Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, India. FAU - Krupa, Murugesan AU - Krupa M AUID- ORCID: 0000-0003-0649-5406 AD - Department of Speech Language Pathology, Sri Ramachandra Faculty of Audiology and Speech Language Pathology, Chennai, India. FAU - Ramaswamy, Karthik Narayanan AU - Ramaswamy KN AUID- ORCID: 0009-0006-2440-3682 AD - Department of Pediatric Intensive Care, Rainbow Children's Hospital and BirthRight Guindy, Chennai, India. LA - eng PT - Journal Article DEP - 20251204 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - India/epidemiology MH - Cross-Sectional Studies MH - Child, Preschool MH - Female MH - Male MH - *Screen Time MH - *Sleep Wake Disorders/epidemiology MH - Prevalence MH - ROC Curve MH - Logistic Models MH - Rural Population PMC - PMC12684157 OTO - NOTNLM OT - Child OT - Community child health OT - EPIDEMIOLOGY OT - PAEDIATRICS OT - PUBLIC HEALTH COIS- Competing interests: None declared. EDAT- 2025/12/05 01:01 MHDA- 2025/12/05 01:02 PMCR- 2025/12/04 CRDT- 2025/12/04 20:44 PHST- 2025/12/05 01:02 [medline] PHST- 2025/12/05 01:01 [pubmed] PHST- 2025/12/04 20:44 [entrez] PHST- 2025/12/04 00:00 [pmc-release] AID - bmjopen-2025-109376 [pii] AID - 10.1136/bmjopen-2025-109376 [doi] PST - epublish SO - BMJ Open. 2025 Dec 4;15(12):e109376. doi: 10.1136/bmjopen-2025-109376. PMID- 41344404 OWN - NLM STAT- MEDLINE DCOM- 20260122 LR - 20260129 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 71 DP - 2026 Feb TI - Multiple regression models to predict electrical bioimpedance variables through anthropometric and simple measures in children aged 6-12 years. PG - 102842 LID - S2405-4577(25)03148-1 [pii] LID - 10.1016/j.clnesp.2025.11.162 [doi] AB - BACKGROUND AND AIMS: Obesity is one of the most common nutritional and metabolic disorders worldwide, affecting all age groups. Multiple regression models can be used to predict bioelectrical impedance analysis (BIA) variables in various populations. These models incorporate a set of anthropometric and simple measures to improve the accuracy of predicting BIA variables. The goal was to develop and internally validate multiple regression models to predict BIA variables using simple clinical and anthropometric measurements in children aged 6-12 years. METHODS: This study employs an observational cross-sectional design. Body mass, height, body composition through BIA, anthropometric circumferences, and skinfolds were evaluated. Anthropometric indices were calculated. Statistical analyses were performed using R software. Non-parametric statistical tests were applied after a normality test. Pearson's correlation coefficients were calculated to assess linear associations between each pair of variables. The multiple regression models were adjusted using a stepwise method with the Akaike information criterion. The significance level was p 6). Group differences used Kruskal-Wallis and Mann-Whitney U tests with Bonferroni correction (P<.004). Associations used chi-square tests with Cramer V. Leak-safe machine learning (patient-wise GroupKFold) classified SevereDay (same day) and SevereTomorrow (next day) using actigraphy, sleep, energy, and demographic data. RESULTS: BD without ADHD showed the tightest coupling of extreme activity with negative mood and energy (Cramer V of up to 0.24; P<.004). ADHD without BD showed stronger links between activity and positive energy. Machine learning achieved a receiver operating characteristic area under the curve (ROC-AUC) of 0.85, an accuracy of 0.79, and an F1-score of 0.67 for SevereDay. SevereTomorrow performance was moderate (ROC-AUC=0.80; accuracy=0.79; F1-score=0.60). Energy variability and actigraphy averages/peaks were the top predictors. CONCLUSIONS: Integrating actigraphy, sleep, and daily energy ratings identifies severe mood days and provides early next-day risk signals in hospitalized adolescents. The findings support wearable-based phenotyping for precision monitoring, with external validation needed in outpatients. CI - (c) Rasim S Diler, Farzan Vahedifard, Boris Birmaher, Satish Iyengar, Maria Wolfe, Brianna N Lepore, Mariah Chobany, Halimah Abdul-Waalee, Greeshma Malgireddy, Jonathan A Hart, Michele A Bertocci. Originally published in JMIR Mental Health (https://mental.jmir.org). FAU - Diler, Rasim S AU - Diler RS AUID- ORCID: 0000-0001-5895-6572 AD - Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, United States, 1 3125136325. FAU - Vahedifard, Farzan AU - Vahedifard F AUID- ORCID: 0000-0002-0803-7831 AD - Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, United States, 1 3125136325. FAU - Birmaher, Boris AU - Birmaher B AUID- ORCID: 0000-0001-9299-6519 AD - Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, United States, 1 3125136325. FAU - Iyengar, Satish AU - Iyengar S AUID- ORCID: 0000-0002-9329-6853 AD - Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, United States, 1 3125136325. FAU - Wolfe, Maria AU - Wolfe M AUID- ORCID: 0009-0009-2385-4379 AD - Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, United States, 1 3125136325. FAU - Lepore, Brianna N AU - Lepore BN AUID- ORCID: 0009-0000-6541-7948 AD - Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, United States, 1 3125136325. FAU - Chobany, Mariah AU - Chobany M AUID- ORCID: 0000-0003-3118-8432 AD - Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, United States, 1 3125136325. FAU - Abdul-Waalee, Halimah AU - Abdul-Waalee H AUID- ORCID: 0009-0005-6560-2816 AD - Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, United States, 1 3125136325. FAU - Malgireddy, Greeshma AU - Malgireddy G AUID- ORCID: 0000-0002-6641-6733 AD - Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, United States, 1 3125136325. FAU - Hart, Jonathan A AU - Hart JA AUID- ORCID: 0009-0003-0825-2587 AD - Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, United States, 1 3125136325. FAU - Bertocci, Michele A AU - Bertocci MA AUID- ORCID: 0000-0002-3857-1226 AD - Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, United States, 1 3125136325. LA - eng GR - R01 MH121451/MH/NIMH NIH HHS/United States GR - S10 OD028483/OD/NIH HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251204 PL - Canada TA - JMIR Ment Health JT - JMIR mental health JID - 101658926 SB - IM MH - Humans MH - *Bipolar Disorder/diagnosis/physiopathology MH - *Actigraphy MH - *Attention Deficit Disorder with Hyperactivity/diagnosis/physiopathology MH - *Machine Learning MH - Male MH - Female MH - Adolescent MH - Self Report MH - Child MH - *Affect/physiology MH - Diagnosis, Differential MH - Severity of Illness Index PMC - PMC12677876 OTO - NOTNLM OT - ADHD OT - actigraphy OT - adolescents OT - attention-deficit/hyperactivity disorder OT - bipolar disorder OT - energy OT - machine learning OT - mood COIS- Conflicts of Interest: FV, SI, JAH, MAB, and RSD have no financial interests or potential conflicts of interest. BB has or will receive royalties for publications from Random House, Inc (New hope for children and teens with bipolar disorder) and Lippincott Williams & Wilkins (Treating child and adolescent depression). He is employed by the University of Pittsburgh and the University of Pittsburgh Medical Center and receives research funding from the National Institute of Mental Health. The funding sources exerted no influence over the work. EDAT- 2025/12/04 19:37 MHDA- 2025/12/04 19:38 PMCR- 2025/12/04 CRDT- 2025/12/04 16:43 PHST- 2025/05/27 00:00 [received] PHST- 2025/09/12 00:00 [revised] PHST- 2025/09/18 00:00 [accepted] PHST- 2025/12/04 19:38 [medline] PHST- 2025/12/04 19:37 [pubmed] PHST- 2025/12/04 16:43 [entrez] PHST- 2025/12/04 00:00 [pmc-release] AID - v12i1e78163 [pii] AID - 78163 [pii] AID - 10.2196/78163 [doi] PST - epublish SO - JMIR Ment Health. 2025 Dec 4;12:e78163. doi: 10.2196/78163. PMID- 41343581 OWN - NLM STAT- MEDLINE DCOM- 20251204 LR - 20251208 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 12 DP - 2025 TI - Association of non-nutritive sweetener consumption with food craving and body image among university students: A cross-sectional study. PG - e0335838 LID - 10.1371/journal.pone.0335838 [doi] LID - e0335838 AB - Non-nutritive sweeteners (NNS) are widely used for weight control and dietary regulation by university students, however, their psychological associations remain unclear. The aim of this study to investigate the associations between NNS consumption and food craving, and body dissatisfaction. A cross-sectional analysis was conducted among 300 students from Applied Science Private University (ASU) in Amman, Jordan. Participants completed a validated online questionnaire including demographic data, NNS consumption, food craving using Food Craving Questionnaire-Trait Rediced (FCQ-Tr), and perceptions of Sihhouette Ratine Scale Dissatisfcation index (SRS-D) body image using. To evaluate the associations between NNS exposure and psychological outcomes, age, sex, body mass index (BMI), dieting status, smoking behavior, were adjusted using multivariable linear and ordinal regression models. The NNS consumption was 83.3% among university students, with 30.0% indicating daily use of NNS. Increased frequency of NNS intake was significantly associated with higher FCQ-T-r scores (beta = 0.21, 95% CI [0.08-0.34], p = 0.002) and elevated SRS-D scores (beta = 0.17, 95% CI [0.05-0.29], p = 0.006). Also (74.3%) reported no mood change after NNS intake, and 21.0% reported mood enhancement. These findings found that frequent NNS = intake is associated with heightened food craving and body dissatisfaction among students, independent of body weight, age, smoking or academic faculty. CI - Copyright: (c) 2025 AL-Dalaeen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Al-Dalaeen, Anfal AU - Al-Dalaeen A AUID- ORCID: 0000-0002-2685-7294 AD - Department of Clinical Nutrition and Dietetics, Faculty of Allied Medical Sciences, Applied Science Private University, Amman, Jordan. FAU - Hamid, Hebah AU - Hamid H AD - Department of Clinical Nutrition and Dietetics, Faculty of Allied Medical Sciences, Applied Science Private University, Amman, Jordan. FAU - Hasan, Tasneem Abu AU - Hasan TA AD - Department of Clinical Nutrition and Dietetics, Faculty of Allied Medical Sciences, Applied Science Private University, Amman, Jordan. LA - eng PT - Journal Article DEP - 20251204 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Non-Nutritive Sweeteners) SB - IM MH - Humans MH - Male MH - Female MH - Cross-Sectional Studies MH - *Students/psychology MH - *Craving MH - *Body Image/psychology MH - Universities MH - Young Adult MH - Adult MH - *Non-Nutritive Sweeteners/administration & dosage MH - Surveys and Questionnaires MH - Adolescent MH - *Feeding Behavior/psychology MH - Jordan MH - Body Mass Index PMC - PMC12677766 COIS- The authors have declared that no competing interests exist. EDAT- 2025/12/04 19:37 MHDA- 2025/12/04 19:38 PMCR- 2025/12/04 CRDT- 2025/12/04 14:03 PHST- 2025/08/20 00:00 [received] PHST- 2025/10/15 00:00 [accepted] PHST- 2025/12/04 19:38 [medline] PHST- 2025/12/04 19:37 [pubmed] PHST- 2025/12/04 14:03 [entrez] PHST- 2025/12/04 00:00 [pmc-release] AID - PONE-D-25-42757 [pii] AID - 10.1371/journal.pone.0335838 [doi] PST - epublish SO - PLoS One. 2025 Dec 4;20(12):e0335838. doi: 10.1371/journal.pone.0335838. eCollection 2025. PMID- 41343399 OWN - NLM STAT- MEDLINE DCOM- 20260323 LR - 20260323 IS - 1939-134X (Electronic) IS - 1040-3590 (Linking) VI - 38 IP - 4 DP - 2026 Apr TI - The development and psychometric validation of the Food and Alcohol Disturbance Expectancy Questionnaire (FAD-EQ) in three independent college student samples. PG - 307-318 LID - 10.1037/pas0001438 [doi] AB - Food and alcohol disturbance (FAD; i.e., use of compensatory behaviors to offset alcohol-related calories and/or to enhance the effects of alcohol) is prevalent among college students and associated with negative consequences. Expectancy effects may play a critical role in understanding the phenomenology and trajectory of FAD, as research from the alcohol and disordered eating literature suggest expectancies are uniquely linked to engagement in these behaviors and their related outcomes. However, little is known about FAD-specific expectancies. This study aimed to develop and psychometrically validate the FAD Expectancy Questionnaire (FAD-EQ). Using three independent multisite samples of U.S. college students (Sample 1: n = 2,594; Sample 2: n = 1,693; Sample 3: n = 3,824), we conducted exploratory and confirmatory factor analyses, tested measurement invariance across sex assigned at birth, evaluated the measure's construct validity, and examined whether FAD expectancy profiles differed by type of past-month FAD engagement. Results supported a two-factor structure (positive and negative FAD expectancies) for the 30-item FAD-EQ, which demonstrated acceptable internal consistency, measurement invariance across sex assigned at birth, and preliminary evidence of convergent and discriminant validity. Similar to results from the alcohol expectancy literature, students engaging in FAD for alcohol enhancement and caloric compensation purposes endorsed the strongest positive and weakest negative expectancies, while students who denied past-month FAD endorsed the weakest positive and strongest negative expectancies. Findings from this study offer a robust tool for assessing FAD expectancies and provide several avenues for future research, intervention, and prevention efforts. (PsycInfo Database Record (c) 2026 APA, all rights reserved). FAU - Berry, Katherine A AU - Berry KA AUID- ORCID: 0000-0002-2632-7437 AD - Department of Psychology, University of Wyoming. FAU - De Young, Kyle P AU - De Young KP AD - Department of Psychology, University of Wyoming. FAU - Looby, Alison AU - Looby A AD - Department of Psychology, University of Wyoming. CN - Stimulant Norms and Prevalence 2 (SNAP2) Study Team LA - eng PT - Journal Article PT - Validation Study DEP - 20251204 PL - United States TA - Psychol Assess JT - Psychological assessment JID - 8915253 SB - IM MH - Humans MH - Female MH - Male MH - Psychometrics MH - *Students/psychology MH - Young Adult MH - Universities MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - Adolescent MH - Adult MH - United States MH - *Alcohol Drinking in College/psychology MH - *Feeding and Eating Disorders/psychology MH - Factor Analysis, Statistical MH - *Feeding Behavior/psychology MH - *Alcohol Drinking/psychology EDAT- 2025/12/04 19:37 MHDA- 2026/03/23 13:03 CRDT- 2025/12/04 13:25 PHST- 2026/03/23 13:03 [medline] PHST- 2025/12/04 19:37 [pubmed] PHST- 2025/12/04 13:25 [entrez] AID - 2026-96056-001 [pii] AID - 10.1037/pas0001438 [doi] PST - ppublish SO - Psychol Assess. 2026 Apr;38(4):307-318. doi: 10.1037/pas0001438. Epub 2025 Dec 4. PMID- 41343193 OWN - NLM STAT- MEDLINE DCOM- 20251204 LR - 20251206 IS - 2047-2986 (Electronic) IS - 2047-2978 (Print) IS - 2047-2978 (Linking) VI - 15 DP - 2025 Dec 5 TI - Establishment and validation of a prediction model for small vulnerable newborns: a retrospective study. PG - 04337 LID - 10.7189/jogh.15.04337 [doi] LID - 04337 AB - BACKGROUND: The concept of small vulnerable newborns has been proposed, including preterm birth, low birth weight, and small for gestational age, leading causes of perinatal mortality. We aimed to identify high-risk factors for small vulnerable newborns and develop a predictive model through a retrospective analysis. METHODS: We collected clinical data from pregnant women who met inclusion criteria between January 2015 and December 2023 and divided them into training and validation cohorts. We used univariate analysis and mean decreases in the Gini index to screen for potential risk factors. We applied the least absolute shrinkage and selection operator regression to select final predictors and construct a nomogram. We assessed model performance using receiver operating characteristic curves, calibration curves, and clinical decision analysis, with internal validation via 10-fold cross-validation and temporal internal validation. RESULTS: Among 129 554 women, 13 801 (10.66%) had small vulnerable newborn, with the incidence increasing from 2015 (10.15%) to 2023 (11.61%). Key risk factors included multiple pregnancies (odds ratio (OR) = 37.2), pre-pregnancy body mass index (BMI) of <18.5 (OR = 8.61) and >/=25 kg/m(2) (OR = 6.40), maternal age of <25 (OR = 6.81) and >/=35 years (OR = 3.72), hypertensive disorders of pregnancy (OR = 2.81), and placental disorders (OR = 3.03). Other significant factors were assisted reproductive technology, mycoplasma/chlamydia infection, and elevated bile acids. The nomogram demonstrated strong predictive performance (area under the curve = 0.873). CONCLUSIONS: The incidence of small, vulnerable newborns rose notably during 2021-2023. The developed model, incorporating age, pre-pregnancy BMI, multiple pregnancies, hypertensive disorders of pregnancy, and placental disorders, is designed to be applied in the third trimester and enables risk identification, facilitating targeted interventions to reduce neonatal mortality and complications. REGISTRATION: Chinese Clinical Trial Registry, ChiCTR2400093923. CI - Copyright (c) 2025 by the Journal of Global Health. All rights reserved. FAU - Xiao, Chengqi AU - Xiao C AD - The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. AD - Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Xu, Chuangchuang AU - Xu C AD - The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. AD - Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Zhang, Lijun AU - Zhang L AD - The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Lai, Dongmei AU - Lai D AD - The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. AD - Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20251205 PL - Scotland TA - J Glob Health JT - Journal of global health JID - 101578780 SB - IM MH - Humans MH - Retrospective Studies MH - Female MH - Infant, Newborn MH - Pregnancy MH - Adult MH - *Infant, Small for Gestational Age MH - Risk Factors MH - Infant, Low Birth Weight MH - Nomograms MH - Risk Assessment PMC - PMC12677243 COIS- Disclosure of interest: The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests. EDAT- 2025/12/04 13:39 MHDA- 2025/12/04 13:40 PMCR- 2025/12/05 CRDT- 2025/12/04 11:34 PHST- 2025/12/04 13:40 [medline] PHST- 2025/12/04 13:39 [pubmed] PHST- 2025/12/04 11:34 [entrez] PHST- 2025/12/05 00:00 [pmc-release] AID - jogh-15-04337 [pii] AID - 10.7189/jogh.15.04337 [doi] PST - epublish SO - J Glob Health. 2025 Dec 5;15:04337. doi: 10.7189/jogh.15.04337. PMID- 41341519 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251204 LR - 20251206 IS - 2164-2850 (Electronic) IS - 2164-2850 (Linking) VI - 13 IP - 1 DP - 2025 TI - Adolescent sleep and food cravings: randomized controlled trial of a sleep intervention. PG - 2590853 LID - 10.1080/21642850.2025.2590853 [doi] LID - 2590853 AB - BACKGROUND: This randomized pilot study examined the relationships between objectively measured sleep characteristics and food cravings in adolescents and examined whether a brief sleep intervention would reduce food cravings from baseline to post-intervention compared to an active control group. METHODS: A community sample of 51 adolescents aged 13-17 years old were randomized to complete a cognitive behavioral therapy (CBT) sleep intervention or a study skills control intervention. The sleep intervention involved one telehealth CBT session, while the control group completed one telehealth CBT session to improve study skills. Sleep was assessed using actigraphs and adolescents reported on food cravings using a validated questionnaire at baseline and post-intervention. RESULTS: Sleep fragmentation, but not sleep duration, was a significant predictor of food cravings at baseline, controlling for age, beta = 0.35, t = 2.41, p = 0.02, 95% CI [0.01-0.11]. The sleep intervention significantly reduced food cravings from baseline to post-intervention compared to the control group (significant time x intervention interaction, F(1, 45) = 4.30, p = 0.044, partial eta(2) = 0.09, medium effect). CONCLUSIONS: The results of this study support the relationship between poor sleep quality and more frequent food cravings, as well as the preliminary efficacy of a brief, CBT-based sleep intervention in reducing food cravings. The brief and digital delivery of this intervention enhances its accessibility. CI - (c) 2025 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. FAU - Kidwell, Katherine M AU - Kidwell KM AD - Department of Psychology, Syracuse University, Marley Education Center, Syracuse, NY, USA. FAU - Hamilton, Antonia L AU - Hamilton AL AD - Department of Psychology, Syracuse University, Marley Education Center, Syracuse, NY, USA. FAU - Deyo, Alexa G AU - Deyo AG AD - Department of Psychology, Syracuse University, Marley Education Center, Syracuse, NY, USA. FAU - Milligan, Megan A AU - Milligan MA AD - Department of Psychology, Syracuse University, Marley Education Center, Syracuse, NY, USA. FAU - Vrabec, Alison AU - Vrabec A AD - Department of Psychology, Syracuse University, Marley Education Center, Syracuse, NY, USA. FAU - Tully, Lyric K AU - Tully LK AD - Department of Psychology, Syracuse University, Marley Education Center, Syracuse, NY, USA. FAU - Yuhas, Maryam AU - Yuhas M AD - Department of Nutrition and Food Studies, Syracuse University, Syracuse, NY, USA. LA - eng PT - Journal Article DEP - 20251130 PL - England TA - Health Psychol Behav Med JT - Health psychology and behavioral medicine JID - 101624393 PMC - PMC12671425 OTO - NOTNLM OT - Sleep treatment OT - actigraph OT - diet OT - single session OT - sleep intervention COIS- No potential conflict of interest was reported by the author(s). EDAT- 2025/12/04 06:27 MHDA- 2025/12/04 06:28 PMCR- 2025/11/30 CRDT- 2025/12/04 04:54 PHST- 2025/12/04 06:28 [medline] PHST- 2025/12/04 06:27 [pubmed] PHST- 2025/12/04 04:54 [entrez] PHST- 2025/11/30 00:00 [pmc-release] AID - 2590853 [pii] AID - 10.1080/21642850.2025.2590853 [doi] PST - epublish SO - Health Psychol Behav Med. 2025 Nov 30;13(1):2590853. doi: 10.1080/21642850.2025.2590853. eCollection 2025. PMID- 41341447 OWN - NLM STAT- MEDLINE DCOM- 20251204 LR - 20251206 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - From habits to harm: the effects of lifestyle, sleep, and fitness on injury risk in students using a structural equation modeling approach. PG - 1664822 LID - 10.3389/fpubh.2025.1664822 [doi] LID - 1664822 AB - BACKGROUND: University students often deal with a mix of challenges - from frequent sports and recreational injuries to habits like smoking, drinking alcohol, or consuming energy drinks, along with irregular sleep and different levels of physical activity. This study examines the links between lifestyle habits, sports participation, sleep quality, self-perceived fitness, and the likelihood of getting injured. METHODS: In a cross-sectional survey of 933 first-year students (mean age 20.1 +/- 2.5), participants reported lifestyle indicators (cigarettes, alcoholic drinks, energy drinks), sports activity (training volume, athlete/competitive status, sport diversity), sleep quality, self-rated fitness, and the number of injuries causing class absence. Partial least squares structural equation modeling evaluated the measurement properties and the structural paths. RESULTS: Sports activity had a strong, positive association with perceived physical fitness. The interaction of lifestyle and sports activity is negatively associated with fitness, indicating that unhealthy habits attenuate sport-related fitness gains. Lifestyle was negatively associated with sleep quality, while better sleep quality positively predicted fitness. Physical fitness did not show a significant direct association with injury counts. Poorer sleep quality was associated with a higher number of injuries. CONCLUSION: In this large student sample, sleep quality emerged as a pivotal, modifiable protector-linked positively to fitness and negatively to injury risk-whereas sports participation improved fitness, but its benefits were undermined by unhealthy lifestyle behaviours. Injury prevention efforts in student populations should therefore combine promotion of healthy lifestyle choices, sleep hygiene interventions, and safe sport practices. CI - Copyright (c) 2025 Kasovic, Skrinjaric, Vespalec, Mojzis and Knjaz. FAU - Kasovic, Mario AU - Kasovic M AD - Department of General and Applied Kinesiology, Faculty of Kinesiology, University of Zagreb, Zagreb, Croatia. AD - Department of Physical Activities and Health Sciences, Faculty of Sports Studies, Masaryk University, Brno, Czechia. FAU - Skrinjaric, Bruno AU - Skrinjaric B AD - Institute of Economics Zagreb, Zagreb, Croatia. FAU - Vespalec, Tomas AU - Vespalec T AD - Department of Physical Activities and Health Sciences, Faculty of Sports Studies, Masaryk University, Brno, Czechia. FAU - Mojzis, Milan AU - Mojzis M AD - Department of Physical Activities and Health Sciences, Faculty of Sports Studies, Masaryk University, Brno, Czechia. FAU - Knjaz, Damir AU - Knjaz D AD - Department of Kinesiology of Sports, Faculty of Kinesiology, University of Zagreb, Zagreb, Croatia. LA - eng PT - Journal Article DEP - 20251118 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Male MH - Female MH - *Students/statistics & numerical data/psychology MH - Cross-Sectional Studies MH - *Life Style MH - Young Adult MH - *Physical Fitness/physiology MH - Latent Class Analysis MH - Universities MH - Adolescent MH - *Sleep MH - Surveys and Questionnaires MH - Exercise MH - *Sleep Quality MH - Sports/statistics & numerical data MH - Adult MH - *Wounds and Injuries/epidemiology MH - Habits PMC - PMC12669233 OTO - NOTNLM OT - injury occurrence OT - lifestyle habits OT - physical fitness OT - sleep quality OT - sports activity COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/04 06:27 MHDA- 2025/12/04 06:28 PMCR- 2025/11/18 CRDT- 2025/12/04 04:53 PHST- 2025/07/14 00:00 [received] PHST- 2025/10/27 00:00 [accepted] PHST- 2025/12/04 06:28 [medline] PHST- 2025/12/04 06:27 [pubmed] PHST- 2025/12/04 04:53 [entrez] PHST- 2025/11/18 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1664822 [doi] PST - epublish SO - Front Public Health. 2025 Nov 18;13:1664822. doi: 10.3389/fpubh.2025.1664822. eCollection 2025. PMID- 41340519 OWN - NLM STAT- MEDLINE DCOM- 20260204 LR - 20260506 IS - 1365-2788 (Electronic) IS - 0964-2633 (Print) IS - 0964-2633 (Linking) VI - 70 IP - 3 DP - 2026 Feb TI - Reliability of Actigraphy for the Assessment of Sleep and Circadian Rhythms in Rett and Related Syndromes. PG - 262-273 LID - 10.1111/jir.70068 [doi] AB - PURPOSE: Actigraphy is being increasingly used to assess sleep and circadian rhythms among populations with intellectual and developmental disabilities and genetic syndromes, including Rett syndrome and related disorders, but the reliability of these measures in these populations is unclear. The primary purpose of the current study was to evaluate the impact of recording duration on the reliability of various measures of sleep and circadian rhythm in Rett and related syndromes. METHOD: Two 14-day recordings were collected between 4 and 12 weeks apart in a sample of 30 individuals (aged 2-36 years; 97% female). Reliability was estimated by calculating statistics based on 3, 5, 7, 10 or 13-14 nights of recording. RESULTS: Most measures of average sleep quality could be reliably estimated with 7-10 nights. Measures of night-to-night variability in sleep timing showed poor reliability at all recording durations, whereas night-to-night variability in sleep duration showed adequate reliability at 5-7 days of recording. The reliability of measures of circadian rhythm was highly variable. CONCLUSIONS: The results suggest that the optimal recording durations for actigraphy in this population vary based on the specific metrics of interest, but most can be measured reliably. CI - (c) 2025 The Author(s). Journal of Intellectual Disability Research published by MENCAP and John Wiley & Sons Ltd. FAU - Byiers, Breanne AU - Byiers B AUID- ORCID: 0000-0002-7645-1479 AD - Department of Educational Psychology, University of Minnesota, Minneapolis, Minnesota, USA. FAU - Merbler, Alyssa AU - Merbler A AUID- ORCID: 0000-0002-8038-3368 AD - Department of Educational Psychology, University of Minnesota, Minneapolis, Minnesota, USA. FAU - Lockhart, Elijah AU - Lockhart E AD - Department of Educational Psychology, University of Minnesota, Minneapolis, Minnesota, USA. FAU - Burkitt, Chantel AU - Burkitt C AUID- ORCID: 0000-0002-1250-181X AD - Gillette Children's, St. Paul, Minnesota, USA. FAU - Symons, Frank AU - Symons F AUID- ORCID: 0000-0001-9833-4807 AD - Department of Educational Psychology, University of Minnesota, Minneapolis, Minnesota, USA. LA - eng GR - R21 HD101075/HD/NICHD NIH HHS/United States GR - R21HD101075/National Institutes of Child Health and Human Development/ PT - Journal Article DEP - 20251204 PL - England TA - J Intellect Disabil Res JT - Journal of intellectual disability research : JIDR JID - 9206090 SB - IM MH - Humans MH - *Actigraphy/standards/methods MH - Female MH - *Rett Syndrome/physiopathology MH - Child MH - Adolescent MH - Young Adult MH - Adult MH - Child, Preschool MH - Male MH - *Circadian Rhythm/physiology MH - Reproducibility of Results MH - Sleep Quality PMC - PMC12872378 OTO - NOTNLM OT - Rett syndrome OT - actigraphy OT - intellectual and developmental disabilities OT - reliability COIS- The authors declare no conflicts of interest. EDAT- 2025/12/04 06:27 MHDA- 2026/02/05 00:30 PMCR- 2026/02/05 CRDT- 2025/12/04 03:24 PHST- 2025/11/14 00:00 [revised] PHST- 2025/05/12 00:00 [received] PHST- 2025/11/20 00:00 [accepted] PHST- 2026/02/05 00:30 [medline] PHST- 2025/12/04 06:27 [pubmed] PHST- 2025/12/04 03:24 [entrez] PHST- 2026/02/05 00:00 [pmc-release] AID - JIR70068 [pii] AID - 10.1111/jir.70068 [doi] PST - ppublish SO - J Intellect Disabil Res. 2026 Feb;70(3):262-273. doi: 10.1111/jir.70068. Epub 2025 Dec 4. PMID- 41339761 OWN - NLM STAT- MEDLINE DCOM- 20251204 LR - 20261009 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 184 IP - 12 DP - 2025 Dec 3 TI - Dietary phytochemical intake and asthma in children: a case-control study. PG - 818 LID - 10.1007/s00431-025-06634-3 [doi] AB - Pediatric asthma is a chronic inflammatory disease marked by bronchial hyperresponsiveness and airflow obstruction. Diet may be associated with asthma risk and severity through anti-inflammatory and antioxidant effects. This research evaluated the connection between the Dietary Phytochemical Index (DPI), which measures the percentage of daily calories from foods high in phytochemicals, and asthma-related outcomes in pediatric populations. In this case-control study with cross-sectional analyses within the asthma group, 300 children aged 5-12 years (150 asthma cases, 150 matched controls) were evaluated. Dietary intake was measured via a validated food frequency questionnaire. DPI was calculated and categorized into tertiles. Clinical outcomes included the Pediatric Asthma Severity Score (PASS), Childhood Asthma Control Test (C-ACT), and Pediatric Asthma Quality of Life Questionnaire (PAQLQ). Serum C-reactive protein (CRP) was measured as an inflammation marker. Children in the highest DPI tertile had lower CRP levels (1.99 vs. 4.02 mg/L), higher PAQLQ scores (4.33 vs. 3.89), lower PASS scores (6.35 vs. 11.14), and higher C-ACT scores (21.45 vs. 13.91; all p < 0.001) than those in the lowest tertile. Higher DPI was associated with lower inflammation (CRP: beta = -0.026), higher quality of life (PAQLQ: beta = 0.058), lower asthma severity (PASS: beta = -0.148), and higher asthma control (C-ACT: beta = 0.364; all p < 0.001). The highest DPI tertile was associated with lower odds of asthma (OR = 0.06; 95% CI: 0.03-0.13; p < 0.001) (fully adjusted for age, sex, BMI, physical activity, energy intake, fiber, and vitamin D). Each one-unit DPI increase was associated with 11% lower odds of asthma (OR = 0.89; 95% CI: 0.86-0.91; p < 0.001), with CRP as the primary inflammation marker assessed. CONCLUSION: Greater intake of phytochemical-rich foods is associated with lower odds of asthma, lower inflammation, and better clinical outcomes in children. WHAT IS KNOWN: * Dietary patterns rich in anti-inflammatory foods may benefit children with asthma. * Phytochemicals have antioxidant and immune-modulating effects relevant to asthma. WHAT IS NEW: * Higher Dietary Phytochemical Index was associated with substantially lower odds of pediatric asthma. * Higher DPI was also associated with lower asthma severity, better asthma control, and lower CRP. * This is the first study to apply DPI to a pediatric asthma population. CI - (c) 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Jiang, Renpeng AU - Jiang R AD - Department of Pediatrics, Shandong Provincial Third Hospital, No. 11 Wuying Mountain Middle Road, Tianqiao District, Jinan City, 250031, Shandong Province, China. FAU - Liu, Weihong AU - Liu W AD - Department of Pediatrics, Shandong Provincial Third Hospital, No. 11 Wuying Mountain Middle Road, Tianqiao District, Jinan City, 250031, Shandong Province, China. FAU - Wang, Guangjun AU - Wang G AD - Department of Pediatrics, Shandong Provincial Third Hospital, No. 11 Wuying Mountain Middle Road, Tianqiao District, Jinan City, 250031, Shandong Province, China. guangjun2010@126.com. LA - eng PT - Journal Article DEP - 20251203 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 0 (Phytochemicals) RN - 9007-41-4 (C-Reactive Protein) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Asthma MH - Child MH - Male MH - Female MH - Case-Control Studies MH - Child, Preschool MH - Cross-Sectional Studies MH - Quality of Life MH - *Phytochemicals/administration & dosage MH - *Diet MH - Severity of Illness Index MH - C-Reactive Protein/analysis MH - Biomarkers/blood OTO - NOTNLM OT - Asthma OT - Child OT - Diet OT - Inflammation OT - Phytochemicals COIS- Declarations. Ethics approval and consent to participate: Ethics approval was obtained from the Ethics Committee of the Shandong Provincial Third Hospital (Approval No: KYLL-2025208). Written informed consent was obtained from all participants. All procedures were conducted in accordance with the Declaration of Helsinki. Consent for publication: All authors endorse the submission of this manuscript to the journal. Patient consent for publication: Not applicable. Competing interest: The authors declare no competing interests. EDAT- 2025/12/04 02:11 MHDA- 2025/12/04 06:26 CRDT- 2025/12/03 23:41 PHST- 2025/08/13 00:00 [received] PHST- 2025/11/10 00:00 [accepted] PHST- 2025/11/04 00:00 [revised] PHST- 2025/12/04 06:26 [medline] PHST- 2025/12/04 02:11 [pubmed] PHST- 2025/12/03 23:41 [entrez] AID - 10.1007/s00431-025-06634-3 [pii] AID - 10.1007/s00431-025-06634-3 [doi] PST - epublish SO - Eur J Pediatr. 2025 Dec 3;184(12):818. doi: 10.1007/s00431-025-06634-3. PMID- 41338958 OWN - NLM STAT- MEDLINE DCOM- 20251203 LR - 20260919 IS - 1440-6047 (Electronic) IS - 0964-7058 (Print) IS - 0964-7058 (Linking) VI - 34 IP - 6 DP - 2026 Dec TI - Predictors of carotenoid status in New Zealand children using carotenoid reflection score: a cross-sectional study. PG - 1007-1018 LID - 10.6133/apjcn.202512_34(6).0014 [doi] AB - BACKGROUND AND OBJECTIVES: Optically-assessed skin carotenoid status offers an objective measure of vegetable and fruit intake. Data from the Sodium and Potassium Intake (SNaK+) study was used to explore asso-ciations of carotenoid reflection scores with body size, annual household income, vegetable and fruit intake and potassium intake, and the relationship between carotenoid reflection score and 24-h urinary potassium in children. METHODS AND STUDY DESIGN: Seventy-five children (29 girls, 37 boys; 9 not stated) aged 8 to 13 years from five New Zealand primary schools were supported by the parents/caregivers to complete validated questions about their frequency of vegetable and fruit intake. Carotenoid reflection scores were measured using reflection spectroscopy and 24-h urine samples (n = 69) were collected. Differences by gender and age were tested using two-sample t-tests. Linear regression identified determinants of carotenoid reflection score. RESULTS: Children's overall mean (standard deviation) carotenoid reflection score was 236 (91), with 51% having low scores (< 250). Younger boys (< 10 years) had higher carotenoid reflection scores than younger girls (mean difference (95% confidence interval); 74 (4, 144). Few (8%, n = 6) children met vegetable intake recommendations. Annual household income and fruit servings per day were predictive correlates of carote-noid reflection scores (R2 = 0.17, F(2.52) = 6.10, p <0.01). Twenty-four-hour urinary potassium did not correlate with carotenoid reflection score. CONCLUSIONS: This study identified low household income and low fruit intake as drivers of low carotenoid status in children, emphasizing the need for targeted dietary interventions. A study is required to further explore the relationship between carotenoid reflection score and potassium excretion. FAU - Rapson, Jeanette AU - Rapson J AD - Department of Epidemiology and Biostatistics, The Centre for Translational Health Research: Informing Policy and Practice (TRANSFORM), The University of Auckland, Auckland, New Zealand. Email: jeanette.rapson@auckland.ac.nz. FAU - Rush, Elaine AU - Rush E AD - Faculty of Health and Environmental Studies, Auckland University of Technology, Auckland, New Zealand. AD - Riddet Centre of Research Excellence, Palmerston North, New Zealand. FAU - McLean, Rachael AU - McLean R AD - Department of Preventive and Social Medicine, The University of Otago, Dunedin, New Zealand. FAU - Fuavao, Kava AU - Fuavao K AD - Department of Epidemiology and Biostatistics, The Centre for Translational Health Research: Informing Policy and Practice (TRANSFORM), The University of Auckland, Auckland, New Zealand. FAU - Wall, Clare AU - Wall C AD - Department of Nutrition and Dietetics, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand. FAU - Eyles, Helen AU - Eyles H AD - Department of Epidemiology and Biostatistics, The Centre for Translational Health Research: Informing Policy and Practice (TRANSFORM), The University of Auckland, Auckland, New Zealand. LA - eng GR - #1821/Heart Foundation of New Zealand/ PT - Journal Article PL - China TA - Asia Pac J Clin Nutr JT - Asia Pacific journal of clinical nutrition JID - 9440304 RN - 36-88-4 (Carotenoids) RN - RWP5GA015D (Potassium) SB - IM MH - Humans MH - *Carotenoids/urine/analysis MH - Male MH - Female MH - Child MH - New Zealand MH - Cross-Sectional Studies MH - Adolescent MH - Vegetables MH - Fruit MH - *Diet MH - *Nutritional Status MH - Potassium/urine PMC - PMC12664544 OTO - NOTNLM OT - Veggie Meter OT - children OT - potassium OT - reflection spectroscopy OT - vegetable consumption COIS- The authors declare no conflict of interest. HE was a Heart Foundation of New Zealand Senior Fellow (#1843) EDAT- 2025/12/04 02:11 MHDA- 2025/12/04 02:12 PMCR- 2025/11/26 CRDT- 2025/12/03 21:22 PHST- 2025/12/04 02:12 [medline] PHST- 2025/12/04 02:11 [pubmed] PHST- 2025/12/03 21:22 [entrez] PHST- 2025/11/26 00:00 [pmc-release] AID - 10.6133/apjcn.202512_34(6).0014 [doi] PST - ppublish SO - Asia Pac J Clin Nutr. 2026 Dec;34(6):1007-1018. doi: 10.6133/apjcn.202512_34(6).0014. PMID- 41338957 OWN - NLM STAT- MEDLINE DCOM- 20251203 LR - 20251207 IS - 1440-6047 (Electronic) IS - 0964-7058 (Print) IS - 0964-7058 (Linking) VI - 34 IP - 6 DP - 2025 Dec TI - Applicability of different resting energy expenditure prediction equations to overweight and obese women of childbearing age with fertility problems. PG - 999-1006 LID - 10.6133/apjcn.202512_34(6).0013 [doi] AB - BACKGROUND AND OBJECTIVES: This study compared the accuracy of current energy formulas in predicting resting energy expenditure (REE) in overweight and obese women with fertility problems. METHODS AND STUDY DESIGN: This study evaluated REE prediction formulas in 82 overweight/obese women (18-49 years) with fertility problems. REE is accurately measured using indirect calorimetry, which is considered the gold standard for evaluating energy. Anthropometric data, including height, weight, and waist circumference. Body composition analysis was performed using bioelectrical impedance analysis to determine fat-free mass and other related indicators. Statistical analyses included Spearman correlation coefficients to assess the relationship between REE and various predictors. The accuracy and reliability of the existing prediction equations were evaluated by comparing their predicted values with resting energy expenditure values measured by Indirect Calorimetry using Bland-Altman analysis. RESULTS: Among the prediction equations assessed, Mifflin's equation demonstrated superior performance in estimating REE in overweight/obese women experiencing fertility problems, exhibiting the least bias (-9.7 kcal/day) and a low standard deviation (240 kcal/day). Variables such as body weight, lean body weight, and central obesity indicators like waist circumference and waist-height ratio emerged as significant predictors of REE, with their impacts being age-dependent. The Mifflin-St. Jeor Equation, which integrates weight, height, and age variables, offers a reasonably accurate estimation of energy needs for this specific demographic. CONCLUSIONS: The Mifflin-St. Jeor Equation is an accurate tool for predicting REE in overweight and obese women with fertility problems, offering important insights for nutritional assessment and intervention strategies in fertility management. FAU - Wu, Xuanhui AU - Wu X AD - Department of Clinical Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, China. AD - School of Public Health, Hebei Medical University, Shijiazhuang, China. AD - Hebei Key Laboratory of Nutrition and Health, Shijiazhuang, China. FAU - Xue, Hongmei AU - Xue H AD - Department of Clinical Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, China. AD - Hebei Key Laboratory of Nutrition and Health, Shijiazhuang, China. FAU - Liang, Mingyue AU - Liang M AD - Department of Clinical Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, China. AD - School of Public Health, Hebei Medical University, Shijiazhuang, China. AD - Hebei Key Laboratory of Nutrition and Health, Shijiazhuang, China. FAU - Wang, Ying AU - Wang Y AD - Department of Clinical Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, China. AD - School of Public Health, Hebei Medical University, Shijiazhuang, China. AD - Hebei Key Laboratory of Nutrition and Health, Shijiazhuang, China. FAU - Xie, Ying AU - Xie Y AD - Department of Clinical Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, China. AD - Hebei Key Laboratory of Nutrition and Health, Shijiazhuang, China. FAU - Zhai, Yijing AU - Zhai Y AD - Department of Clinical Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, China. AD - Hebei Key Laboratory of Nutrition and Health, Shijiazhuang, China. FAU - Xu, Bianling AU - Xu B AD - Department of Obstetrics and Gynecology, The First Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Song, Chao AU - Song C AD - National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, China. FAU - Li, Xiaodong AU - Li X AD - Department of Obstetrics and Gynecology, The First Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Lai, Jianqiang AU - Lai J AD - Chinese Center for Disease Control and Prevention, Beijing, China. FAU - Li, Zengning AU - Li Z AD - Department of Clinical Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, China. Email: zengningli@hebmu.edu.cn. AD - School of Public Health, Hebei Medical University, Shijiazhuang, China. AD - Hebei Key Laboratory of Nutrition and Health, Shijiazhuang, China. LA - eng GR - No.2025033/Scientific Research Project Plan of Traditional Chinese Medicine in Hebei Province/ GR - CNS-NNSRG2022-231/National Nutrition Research Foundation of Chinese Nutrition Society/ GR - No.H2023206219/Natural Science Foundation of Hebei Province/ PT - Journal Article PL - China TA - Asia Pac J Clin Nutr JT - Asia Pacific journal of clinical nutrition JID - 9440304 SB - IM MH - Humans MH - Female MH - Adult MH - *Obesity/metabolism/complications MH - *Overweight/metabolism/complications MH - Middle Aged MH - Adolescent MH - Young Adult MH - *Energy Metabolism/physiology MH - *Basal Metabolism/physiology MH - Calorimetry, Indirect MH - Body Composition PMC - PMC12664540 OTO - NOTNLM OT - energy expenditure OT - fertility problems OT - overweight and obese OT - prediction equations OT - women COIS- The authors declare no conflict of interest EDAT- 2025/12/04 02:11 MHDA- 2025/12/04 02:12 PMCR- 2025/11/26 CRDT- 2025/12/03 21:22 PHST- 2025/12/04 02:12 [medline] PHST- 2025/12/04 02:11 [pubmed] PHST- 2025/12/03 21:22 [entrez] PHST- 2025/11/26 00:00 [pmc-release] AID - 10.6133/apjcn.202512_34(6).0013 [doi] PST - ppublish SO - Asia Pac J Clin Nutr. 2025 Dec;34(6):999-1006. doi: 10.6133/apjcn.202512_34(6).0013. PMID- 41338692 OWN - NLM STAT- MEDLINE DCOM- 20251203 LR - 20260919 IS - 1938-3207 (Electronic) IS - 0002-9165 (Print) IS - 0002-9165 (Linking) VI - 122 IP - 6 DP - 2025 Dec TI - Development and validation of a brief Nutrition Security Screener (NSS) for clinical and public health settings. PG - 1689-1700 LID - S0002-9165(25)00513-1 [pii] LID - 10.1016/j.ajcnut.2025.08.017 [doi] AB - BACKGROUND: Nutrition security encompasses access, availability, and affordability of foods that support well-being and prevent and manage diet-related conditions. Although food security is widely studied, validated nutrition security measures are not yet widespread, highlighting a critical gap in clinical and public health research and practice. OBJECTIVES: This study aims to validate a brief Nutrition Security Screener (NSS) in the United States. METHODS: The NSS was refined in pilot studies and implemented in 5 diverse populations, totaling 20,523 adults. Two items assessed the presence and severity of nutrition insecurity (NI) and 13 corresponding barriers. Multivariable logistic regression models and pooled analyses examined distributions and associations of NI with food insecurity (FI), sociodemographic characteristics, and health. RESULTS: Across county, state, and national levels, NI prevalence ranged 18%-44% and varied by sociodemographic characteristics. About 60% of young adults reported NI, compared with 13% of older adults. NI was most prevalent among Hispanic/Latinx (26%-62%) compared with White (10%-40%) adults and those with the lowest (49%-65%) compared with the highest (3%-13%) income. NI only moderately correlated with FI measured by The Hunger Vital Sign (r = 0.55-0.63) and 6-item United States Department of Agriculture Module (r = 0.38-0.46), with discordance in 10%-28% of respondents. Adjusting for sociodemographic characteristics and FI, NI was independently associated with diabetes odds ratio (OR) = 1.46 [95% confidence interval (CI): 1.19, 1.79], obesity [OR = 1.42 (1.19, 1.70)], hypertension [OR = 1.34 (1.13, 1.59)], hypercholesterolemia [OR = 1.34 (1.11, 1.61)], heart disease [OR = 1.39 (1.05, 1.85)], and stroke [OR = 2.03 (1.08, 3.83)], but not cancer [OR = 0.98 (0.62, 1.54)]. Common barriers were expense (75%-81%), cultural or traditional foods being unhealthy (47%-75%), and limited access to healthy choices (47%-53%). Affirming more barriers was associated with higher odds of all health outcomes except cancer. CONCLUSIONS: A brief NSS enables assessment of NI prevalence and barriers to healthy eating in diverse populations, and is independently associated with diet-related disease, informing clinical, public health, and policy efforts to screen for and address NI. CI - Copyright (c) 2025 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Craig, Hope C AU - Craig HC AD - Food is Medicine Institute, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA. Electronic address: hope.craig@tufts.edu. FAU - Sharib, Julia Reedy AU - Sharib JR AD - Food is Medicine Institute, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA. FAU - Ridberg, Ronit AU - Ridberg R AD - Food is Medicine Institute, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA. FAU - Caldwell, Julia AU - Caldwell J AD - Los Angeles County Department of Public Health, Los Angeles, CA, USA. FAU - Shah-Patel, Dipa AU - Shah-Patel D AD - Los Angeles County Department of Public Health, Los Angeles, CA, USA. FAU - Warner, Kelly AU - Warner K AD - Los Angeles County Department of Public Health, Los Angeles, CA, USA. FAU - de la Haye, Kayla AU - de la Haye K AD - Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA. FAU - Livings, Michelle AU - Livings M AD - Department of Health Sciences, Rutgers University-Camden, Camden, NJ, USA. FAU - Brown, Meagan C AU - Brown MC AD - Kaiser Permanente Washington Health Research Unit, Seattle, WA, USA. FAU - Chao, Ceping AU - Chao C AD - Kaiser Permanente, Los Angeles, CA, USA. FAU - Habib, Mina AU - Habib M AD - Kaiser Permanente, Los Angeles, CA, USA. FAU - Cushing-Haugen, Kara AU - Cushing-Haugen K AD - Kaiser Permanente Washington Health Research Unit, Seattle, WA, USA. FAU - Nau, Claudia AU - Nau C AD - Kaiser Permanente, Los Angeles, CA, USA. FAU - Schwartz, Pamela AU - Schwartz P AD - Kaiser Permanente, Los Angeles, CA, USA. FAU - Mozaffarian, Dariush AU - Mozaffarian D AD - Food is Medicine Institute, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA; Division of Cardiology, Tufts Medical Center, and Tufts University School of Medicine, Boston, MA, USA. LA - eng GR - R01 HL115189/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Validation Study DEP - 20251020 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Humans MH - Adult MH - Male MH - Female MH - Middle Aged MH - United States MH - *Food Insecurity MH - *Public Health MH - Aged MH - Young Adult MH - Adolescent MH - *Food Security MH - *Food Supply MH - Nutritional Status PMC - PMC12676013 MID - NIHMS2112458 OTO - NOTNLM OT - diet-related disease OT - food is medicine OT - food security OT - nutrition security OT - screening tools COIS- Conflict of interest Meagan C. Brown, Ceping Chao, Mina Habib, Kara Cushing-Haugen, Claudia Nau, and Pamela Schwartz are affiliates of Kaiser Permanente, which supported the National Social Health Survey and the Food is Medicine Surveys. All other authors report no conflicts of interest. EDAT- 2025/12/04 02:11 MHDA- 2025/12/04 02:12 PMCR- 2026/07/17 CRDT- 2025/12/03 20:54 PHST- 2025/02/25 00:00 [received] PHST- 2025/08/19 00:00 [revised] PHST- 2025/08/25 00:00 [accepted] PHST- 2025/12/04 02:12 [medline] PHST- 2025/12/04 02:11 [pubmed] PHST- 2025/12/03 20:54 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - S0002-9165(25)00513-1 [pii] AID - 10.1016/j.ajcnut.2025.08.017 [doi] PST - ppublish SO - Am J Clin Nutr. 2025 Dec;122(6):1689-1700. doi: 10.1016/j.ajcnut.2025.08.017. Epub 2025 Oct 20. PMID- 41338598 OWN - NLM STAT- MEDLINE DCOM- 20251203 LR - 20260109 IS - 2052-4439 (Electronic) IS - 2052-4439 (Linking) VI - 12 IP - 1 DP - 2025 Dec 3 TI - Development of the Cystic Fibrosis Stress Questionnaire: testing and validation. LID - 10.1136/bmjresp-2025-003322 [doi] LID - e003322 AB - OBJECTIVE: Care guidelines for cystic fibrosis (CF) recommend annual screening for anxiety and depression using standardised measures, the Patient Health Questionnaire (PHQ-9) and the Generalised Anxiety Disorder Scale (GAD-7). Research in other chronic illness groups such as diabetes has demonstrated that illness-specific distress predicts daily functioning above and beyond depression alone. To address the need for a measure of illness-specific distress, we developed and validated the CF Stress Questionnaire (CFSQ), which could serve as a meaningful adjunct to mental health screening. METHODS: We developed a CF-specific measure of perceived stress with multiple phases of input from our patient population. We then conducted a multisite CFSQ validation study with 200 adults with CF across 3 geographically diverse CF centres, to examine the CFSQ's factor structure, internal consistency, convergent validity and test-retest reliability. RESULTS: Results of item and subscale-level analyses indicate that all but one subscale met the established internal consistency cut-off of >0.6. In terms of convergent validity, the CFSQ and its subscales were moderately to highly correlated with the PHQ-9 (r=0.73 for total score, p<0.05) and the GAD-7 (r=0.66 for total score, p<0.05) and moderately correlated with quality of life as measured by the Cystic Fibrosis Questionnaire Revised (CFQ-R) Social (r=-0.59 for total score, p<0.05) and Treatment Burden subscales (r=-0.63 for total score, p<0.05). Subscales of the CFSQ were moderately correlated with the CFQ-R Emotional or Physical Functioning subscales, and weakly correlated with forced expiratory volume in 1 s per cent predicted or body mass index. CONCLUSIONS: The CFSQ is a valid and reliable measure in terms of internal consistency and convergent validity with existing measures of mental health and quality of life commonly used in CF care and research. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Snell, Carolyn J AU - Snell CJ AUID- ORCID: 0000-0002-6292-2516 AD - Pulmonary Medicine, Boston Children's Hospital, Boston, Massachusetts, USA carolyn.snell@childrens.harvard.edu. AD - Harvard Medical School, Boston, Massachusetts, USA. FAU - Ryan, Morgan E AU - Ryan ME AD - Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Bailey, Isabel V AU - Bailey IV AD - Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Sandage, Danielle AU - Sandage D AD - Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Ertman, Benjamin AU - Ertman B AD - Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Dahlberg, Suzanne AU - Dahlberg S AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Alpern, Adrianne N AU - Alpern AN AD - Children's Hospital of Orange County, Orange, California, USA. FAU - Smith, Beth AU - Smith B AD - Division of Child and Adolescent Psychiatry, State University of New York, Buffalo, New York, USA. FAU - Garcia, Bryan AU - Garcia B AD - Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA. FAU - Ito, Ethan AU - Ito E AD - Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Sawicki, Gregory AU - Sawicki G AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Uluer, Ahmet AU - Uluer A AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Boston Children's Hospital, Boston, Massachusetts, USA. LA - eng PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20251203 PL - England TA - BMJ Open Respir Res JT - BMJ open respiratory research JID - 101638061 SB - IM MH - Humans MH - *Cystic Fibrosis/psychology/complications MH - Male MH - Female MH - Adult MH - Reproducibility of Results MH - *Stress, Psychological/diagnosis/etiology MH - Middle Aged MH - Surveys and Questionnaires MH - Young Adult MH - Psychometrics MH - *Depression/diagnosis MH - *Anxiety/diagnosis MH - Adolescent MH - Quality of Life MH - Patient Health Questionnaire PMC - PMC12682168 OTO - NOTNLM OT - Cystic Fibrosis OT - Psychology OT - Surveys and Questionnaires COIS- Competing interests: None declared. EDAT- 2025/12/04 02:11 MHDA- 2025/12/04 02:12 PMCR- 2025/12/03 CRDT- 2025/12/03 20:32 PHST- 2025/04/07 00:00 [received] PHST- 2025/11/01 00:00 [accepted] PHST- 2025/12/04 02:12 [medline] PHST- 2025/12/04 02:11 [pubmed] PHST- 2025/12/03 20:32 [entrez] PHST- 2025/12/03 00:00 [pmc-release] AID - 12/1/e003322 [pii] AID - bmjresp-2025-003322 [pii] AID - 10.1136/bmjresp-2025-003322 [doi] PST - epublish SO - BMJ Open Respir Res. 2025 Dec 3;12(1):e003322. doi: 10.1136/bmjresp-2025-003322. PMID- 41334886 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260904 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) VI - 32 IP - 5 DP - 2026 Sep TI - Cross-sectional study of taste perception and related factors for healthy eating habits among Japanese schoolchildren. PG - 1703-1712 LID - 10.1177/02601060251399253 [doi] AB - Background: Taste perception plays an important role in a person's food preferences. Promoting an interest in taste and developing taste perception are important factors for healthy eating habits. However, only a few studies have been conducted to investigate the association of taste perception with personal background factors, nutrition, and eating habits. Aim: To investigate the current status and associated factors of taste perception among primary school children in Japan through a cross-sectional study design. Methods: A total of 77 children aged 9-11 years participated in this study between July and August 2022. Taste perception was assessed using the validated "Taste Strips" test, and participants were classified as either having high taste perception if their total taste score was >/=9 or having low taste perception if their score was <9. Data on demographic characteristics, anthropometric measurements, eating habits, nutrient intake, and self-efficacy were collected through questionnaires and regular health checkups. Results: Among the participants, 20% were classified as having low taste perception. Multivariable logistic regression analysis showed that family commensality at dinner (adjusted odds ratio: 5.4, 95% confidence interval: 1.1-28.0) and having a positive attitude (adjusted odds ratio: 1.1, 95% confidence interval: 1.0-1.1) were significantly associated with children's taste perception. Conclusion: Our findings underscore the importance of nutrition education and the home environment in supporting the development of taste perception, potentially guiding interventions to promote healthy eating habits during children's critical formative period. FAU - Ando, Hitomi AU - Ando H AUID- ORCID: 0000-0002-4564-4083 AD - College of Nursing Art and Science, University of Hyogo, Akashi, Hyogo, Japan. RINGGOLD: 12743 AD - Division of Health Sciences, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan. FAU - Kinouchi, Kaori AU - Kinouchi K AUID- ORCID: 0000-0001-9110-9770 AD - Division of Health Sciences, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan. FAU - Watanabe, Hiroko AU - Watanabe H AUID- ORCID: 0000-0001-6700-627X AD - Division of Health Sciences, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan. LA - eng PT - Journal Article DEP - 20251203 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 RN - Japanese people SB - IM MH - Humans MH - Child MH - Cross-Sectional Studies MH - Female MH - Male MH - Japan MH - *Feeding Behavior/psychology MH - *Taste Perception MH - Food Preferences/psychology MH - *Diet, Healthy/psychology MH - Surveys and Questionnaires MH - East Asian People OTO - NOTNLM OT - Taste perception OT - eating habits OT - health education OT - self-efficacy OT - taste test COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Data availabilityData will be made available on request. EDAT- 2025/12/03 14:12 MHDA- 2026/09/03 17:36 CRDT- 2025/12/03 08:52 PHST- 2026/09/03 17:36 [medline] PHST- 2025/12/03 14:12 [pubmed] PHST- 2025/12/03 08:52 [entrez] AID - 10.1177/02601060251399253 [doi] PST - ppublish SO - Nutr Health. 2026 Sep;32(5):1703-1712. doi: 10.1177/02601060251399253. Epub 2025 Dec 3. PMID- 41332253 OWN - NLM STAT- MEDLINE DCOM- 20251203 LR - 20251206 IS - 1550-2783 (Electronic) IS - 1550-2783 (Linking) VI - 22 IP - 1 DP - 2025 Dec 31 TI - Prevalence of physically active females at risk for the female athlete triad in Spain. PG - 2590641 LID - 10.1080/15502783.2025.2590641 [doi] LID - 2590641 AB - BACKGROUND: The female athlete triad (Triad) refers to the interrelationship between energy availability, menstrual function, and bone health, which may have clinical and subclinical manifestations including eating disorders, functional hypothalamic amenorrhea, and osteoporosis. The aim of this study was to analyze the prevalence of physically active 15- to 45-year-old Spanish women at risk for the Triad. METHODS: A descriptive cross-sectional study was carried out using the validated questionnaires 'Low Energy Availability in Females Questionnaire' (LEAF-Q) and the 'Female Athlete Screening Tool' (FAST). Exercising women were invited to participate anonymously and voluntarily by email via Spanish sports clubs and federations, as well as through social networks. The questionnaires were also distributed to elite athletes attending the High Performance Center of Sant Cugat del Valles (Barcelona). RESULTS: The study participants comprised 1154 physically active women (age = 28.5 +/- 7.7 years; height = 165.2 +/- 6.2 cm; body weight = 60.5 +/- 9.7), representing 78 recreational and competitive level sports. The results showed that 40.0% (n = 462) were considered at risk for the Triad, while 24.3% (n = 280) were at risk for subclinical eating disorder, and 7.3% (n = 84) at risk for clinical eating disorder. Other results were: menstrual dysfunction displayed a positive correlation with the LEAF-Q score (r = 0.499, p = < 0.001); FAST presented an association with the LEAF-Q score (r = 0.252, p < 0.001); and body weight (r = 0.207, p = < 0.001) and body mass index (r = 0.225, p = < 0.001) displayed a positive correlation with the FAST score. CONCLUSION: Based on this research, the implementation of strategies for the prevention, diagnosis and treatment of the Triad disorders should be made a priority among physically active Spanish women. FAU - Torres Dos Ramos, Ana AU - Torres Dos Ramos A AUID- ORCID: 0009-0007-6104-9632 AD - Faculty of Health Sciences, Universitat Oberta de Catalunya, Barcelona, Spain. FAU - Bellver, Montse AU - Bellver M AUID- ORCID: 0000-0002-3081-0165 AD - Centro de Alto Rendimiento (CAR), Sant Cugat del Valles, Barcelona, Spain. AD - Consorcio Sanitario de Terrassa, Terrassa, Spain. FAU - Esquius, Laura AU - Esquius L AUID- ORCID: 0000-0002-1009-5379 AD - Epi4health Research Group, Faculty of Health Sciences, Universitat Oberta de Catalunya, Barcelona, Spain. FAU - Martinez Pastor, Ivan AU - Martinez Pastor I AUID- ORCID: 0009-0008-6298-6158 AD - Gesein, S.L., Madrid, Spain. FAU - Barea Montes, Antonia AU - Barea Montes A AD - Centro de Alto Rendimiento (CAR), Sant Cugat del Valles, Barcelona, Spain. AD - Consorcio Sanitario de Terrassa, Terrassa, Spain. FAU - Andres, Ana AU - Andres A AUID- ORCID: 0000-0002-6488-1658 AD - Faculty of Psychology, Education and Sport Sciences Blanquerna, Ramon Llull University, Barcelona, Spain. LA - eng PT - Journal Article DEP - 20251202 PL - United States TA - J Int Soc Sports Nutr JT - Journal of the International Society of Sports Nutrition JID - 101234168 SB - IM MH - Humans MH - Female MH - Spain/epidemiology MH - Cross-Sectional Studies MH - *Female Athlete Triad Syndrome/epidemiology MH - Prevalence MH - Adult MH - Young Adult MH - Adolescent MH - Middle Aged MH - *Exercise MH - Surveys and Questionnaires MH - Feeding and Eating Disorders/epidemiology MH - Risk Factors MH - Athletes PMC - PMC12677033 OTO - NOTNLM OT - Amenorrhea OT - disordered eating OT - energy deficiency OT - menstrual cycle OT - women in sport COIS- None. No potential conflict of interest was reported by the authors. EDAT- 2025/12/03 07:40 MHDA- 2025/12/03 07:41 PMCR- 2025/12/02 CRDT- 2025/12/03 03:03 PHST- 2025/12/03 07:41 [medline] PHST- 2025/12/03 07:40 [pubmed] PHST- 2025/12/03 03:03 [entrez] PHST- 2025/12/02 00:00 [pmc-release] AID - 2590641 [pii] AID - 10.1080/15502783.2025.2590641 [doi] PST - ppublish SO - J Int Soc Sports Nutr. 2025 Dec 31;22(1):2590641. doi: 10.1080/15502783.2025.2590641. Epub 2025 Dec 2. PMID- 41331935 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260626 IS - 0778-7367 (Print) IS - 2049-3258 (Electronic) IS - 0778-7367 (Linking) VI - 84 IP - 1 DP - 2025 Dec 2 TI - Does the physical activity-adolescent mental health model generalize across different social environments? PG - 4 LID - 10.1186/s13690-025-01806-x [doi] LID - 4 AB - BACKGROUND: Insufficient physical activity, high prevalence of psychological problems, and inadequate sleep duration among adolescents are major public health concerns. To provide theoretical guidance for addressing these issues, Dong Rubao et al. proposed a holistic health-based model in which physical activity promotes adolescent mental health through the multiple mediating effects of general self-efficacy and sleep duration. If valid, this model could offer both theoretical and practical guidance for integrated solutions to insufficient physical activity, inadequate sleep, and poor mental health among adolescents. At the same time, it may maximize health promotion effects while saving time for adolescents with heavy academic workloads, and encourage the adoption of a holistic perspective in health promotion efforts. However, the original study was based only on cross-sectional survey data, leaving uncertainty about the model's validity across different social contexts. Since adolescent physical activity, sleep duration, and mental health are influenced by diverse factors, particularly the physical activity environment, further validation is needed. OBJECTIVE: This study aimed to examine the validity of the adolescent health promotion model across different social environments and to provide evidence for its practical application. From 2021 to 2023, we randomly extracted 1,073 sets of survey data per year from an adolescent health database containing measures of physical activity, sleep duration, general self-efficacy, and mental health. The data were collected in three distinct contexts: the normalized prevention and control stage of COVID-19 in 2021, the outbreak stage in 2022, and the post-control stage in 2023. These datasets were used to test the theoretical model constructed by Dong Rubao et al. METHODS: Cross-sectional surveys conducted over three consecutive years provided data on adolescent level of physical activity (PAL), sleep duration (SD), general self-efficacy (GSE), and mental health (MH). Normality and correlation analyses were performed using SPSS 26.0. Bootstrap inference for model coefficients was conducted using PROCESS v4.1 by Andrew F. Hayes (Model 4). Effect size tests for the structural equation model were conducted in AMOS 26.0. RESULTS: The average sleep duration(SD) for adolescents was 440.15, 430.14, and 441.80 mins/day respectively (F = 9.62, p < 0.001), PAL was 2.54, 2.35, and 2.46 respectively (F = 18.87, p < 0.001), GSE was 2.65, 2.36, and 2.71 respectively (F = 74.53, p < 0.001), and MH was 1.54, 1.86, and 1.57 respectively (F = 87.31, < 0.001); ANOVA results showed significant differences. There were significantly correlated with each other among average of PAL, SD, GSE and MH. The total effects of the model were - 0.196, - 0.338, and - 0.221, respectively, all with P < 0.001; the direct effects were - 0.089, - 0.230, and - 0.117, respectively, all with P < 0.001; the total indirect effects were - 0.107, - 0.107, and - 0.104, respectively; with PAL-->SD-->MH was - 0.077, - 0.051, and - 0.063, and PAL-->GSE-->MH was - 0.031, - 0.057, and - 0.041, all with a significant meaning in the Bias-Corrected 95%CI test. However, during the COVID-19 outbreak, few fit indices of the model did not reach ideal values. SD and GSE play multiple mediating roles in Physical and Mental Health Promotion Model for Adolescent. CONCLUSION: The adolescent health promotion model is generally valid across different social environments. However, in contexts lacking sufficient PA opportunities, the model shows relatively poorer fit. In practice, health promotion among adolescents should address insufficient PA, high prevalence of mental health problems, and inadequate sleep duration as interrelated issues, in order to achieve more comprehensive effects. FAU - Dou, Kai-Yun AU - Dou KY AD - College of Physical Education and Health, Guangxi Normal University, Guilin, Guangxi, 541006, China. FAU - Dong, Ru-Bao AU - Dong RB AD - College of Physical Education and Health, Guangxi Normal University, Guilin, Guangxi, 541006, China. dongrubao05@163.com. FAU - Huang, Jiaben AU - Huang J AD - Qingyuan Polytechnic, Qingyuan, Guangdong, 511510, China. LA - eng GR - No.17BTY081/National Social Science Fund of China/ PT - Journal Article DEP - 20251202 PL - England TA - Arch Public Health JT - Archives of public health = Archives belges de sante publique JID - 9208826 PMC - PMC12777160 OTO - NOTNLM OT - Adolescents OT - Mental health OT - Pandemic OT - Physical activity OT - Self-efficacy OT - Sleep COIS- Declarations. Ethical approval and consent to participate: The study was approved by the Ethics Committee at the school of physical education of Guizhou Normal University of China (No.20170729). All methods were carried out in accordance with relevant guidelines and regulations. Before the start of this study, informed consent was obtained from all participants. The respondents were recruited through oral propaganda. Before recruitment, a survey obtained the consent of the principal of the school where the interviewees (teenagers) belong, and required the orally recruited teenagers to bring back a "Parent Informed Consent Form" to their parents for reading and signing. Only the teenagers who submitted the signed "Parents Informed Consent Form" for "Consent" could participated in the survey. And informed them have the right to withdraw freely from the survey. Consent for publication: No individual or indemnifiable data is being published as part of this manuscript. Competing interests: The authors declare no competing interests. EDAT- 2025/12/03 07:41 MHDA- 2025/12/03 07:42 PMCR- 2025/12/02 CRDT- 2025/12/03 00:27 PHST- 2025/08/16 00:00 [received] PHST- 2025/11/25 00:00 [accepted] PHST- 2025/12/03 07:42 [medline] PHST- 2025/12/03 07:41 [pubmed] PHST- 2025/12/03 00:27 [entrez] PHST- 2025/12/02 00:00 [pmc-release] AID - 10.1186/s13690-025-01806-x [pii] AID - 1806 [pii] AID - 10.1186/s13690-025-01806-x [doi] PST - epublish SO - Arch Public Health. 2025 Dec 2;84(1):4. doi: 10.1186/s13690-025-01806-x. PMID- 41331876 OWN - NLM STAT- MEDLINE DCOM- 20260108 LR - 20260110 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2025 Dec 3 TI - Associations of nutritional habits, lifestyle, and demographic factors with mental health outcomes among university students in Lebanon: a cross-sectional study. PG - 91 LID - 10.1186/s12889-025-25664-y [doi] LID - 91 AB - BACKGROUND: Growing evidence highlights the role of dietary habits in shaping mental health outcomes, particularly among young adults. This study aimed to examine the associations between dietary intake of fat and sugar and mental health outcomes-specifically depression and anxiety-among university students in Lebanon. METHODS: A cross-sectional survey was conducted between January and May 2025 across five major universities in Lebanon. A total of 646 students aged 18-30 years completed a self-administered online questionnaire. Dietary intake of fats and free sugars was assessed using the validated Dietary Fat and Free Sugar Questionnaire (DFS). Mental health outcomes were measured using the Patient Health Questionnaire-9 for depression (PHQ-9) and the General Anxiety Disorder (GAD-7). Descriptive statistics, bivariate analyses, and logistic regressions were performed to evaluate associations between dietary fat or sugar intake and mental health outcomes, adjusting for relevant confounders. RESULTS: Among 646 university students (64.9% females, mean age = 20.8 +/- 3.7 years), 74.8% reported depressive symptoms, 72.1% reported anxiety. The mean consumption of fat and sugar was 29 +/- 6.7 and 15 +/- 4.4, respectively using the DFS Fat and Sugar subscales. In multivariable analysis, depression was significantly associated with overall health, moderate alcohol consumption, physical activity, fat intake and sugar intake, while anxiety was significantly linked to overall health, caffeine consumption, sugar intake, but not fat intake. CONCLUSIONS: Our findings call for integrated, holistic health promotion strategies within university settings that combine nutrition education, physical activity encouragement and mental health support. CI - (c) 2025. The Author(s). FAU - Boutros, Paula Hage AU - Boutros PH AD - Department of Nutrition, Faculty of Health Sciences, Modern University for Business and Science, Ramiz Sarkis, Beirut, 11-37501, Lebanon. phage@mubs.edu.lb. FAU - Papazian, Tatiana AU - Papazian T AD - Department of Nutrition, Faculty of Pharmacy, Saint Joseph University of Beirut, Riad El Solh, Beirut, 11-5076, Lebanon. FAU - Tawtah, Lynn AU - Tawtah L AD - Department of Nutrition, Faculty of Pharmacy, Saint Joseph University of Beirut, Riad El Solh, Beirut, 11-5076, Lebanon. FAU - Merhi, Samar AU - Merhi S AD - Faculty of Nursing and Health Sciences, Notre Dame University-Louaize, Zouk Mosbeh, Lebanon. FAU - Salameh, Estelle AU - Salameh E AD - Faculty of Nursing and Health Sciences, Notre Dame University-Louaize, Zouk Mosbeh, Lebanon. FAU - Fares, Jessy El Hayek AU - Fares JEH AD - Faculty of Nursing and Health Sciences, Notre Dame University-Louaize, Zouk Mosbeh, Lebanon. LA - eng PT - Journal Article DEP - 20251203 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - 0 (Dietary Fats) RN - 0 (Dietary Sugars) SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Lebanon/epidemiology MH - Male MH - Universities MH - Young Adult MH - Adult MH - *Students/psychology/statistics & numerical data MH - Adolescent MH - *Feeding Behavior/psychology MH - *Life Style MH - *Depression/epidemiology MH - Surveys and Questionnaires MH - *Anxiety/epidemiology MH - *Mental Health/statistics & numerical data MH - Dietary Fats/administration & dosage MH - Sociodemographic Factors MH - Dietary Sugars/administration & dosage PMC - PMC12781419 OTO - NOTNLM OT - Anxiety OT - Cross-sectional studies OT - Depression OT - Fat intake OT - Lebanon OT - Mental health OT - Physical activity OT - Students OT - Sugar intake OT - Surveys and questionnaires COIS- Declarations. Ethics approval and consent to participate: The research protocol was approved by the Modern University for Business and Science (MUBS) Institutional Review Board (MU-20241220-52), the Notre Dame University-Louaize (NDU) Institutional Review Board (IRB 202501), and the ethical committee of Saint Joseph University (USJ) (CER-2025-82) before data collection and was performed in accordance with the Declaration of Helsinki. Participants were informed about the purpose of the study before participation and provided informed consent by selecting "I agree" on the first page of the survey hosted on the online platform Google Forms. Only consenting individuals were able to proceed. The survey was anonymous, with no personal identifiers collected. Participants were informed they could withdraw at any time without penalty. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/03 07:41 MHDA- 2026/01/08 07:13 PMCR- 2025/12/03 CRDT- 2025/12/03 00:19 PHST- 2025/08/25 00:00 [received] PHST- 2025/11/12 00:00 [accepted] PHST- 2026/01/08 07:13 [medline] PHST- 2025/12/03 07:41 [pubmed] PHST- 2025/12/03 00:19 [entrez] PHST- 2025/12/03 00:00 [pmc-release] AID - 10.1186/s12889-025-25664-y [pii] AID - 25664 [pii] AID - 10.1186/s12889-025-25664-y [doi] PST - epublish SO - BMC Public Health. 2025 Dec 3;26(1):91. doi: 10.1186/s12889-025-25664-y. PMID- 41331591 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260627 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2025 Dec 2 TI - Development and initial validation of the adolescent exercise habits scale among Chinese population. PG - 82 LID - 10.1186/s12889-025-25818-y [doi] LID - 82 AB - BACKGROUND: Establishing regular exercise habits during adolescence is essential for fostering lifelong physical activity participation. Despite its importance, reliable and culturally appropriate tools to assess exercise habits among Chinese adolescents remain limited. This study aimed to develop and validate the adolescent exercise habit scale (AEHS), a psychometrically sound instrument for assessing self-reported exercise habits in this population. METHODS: Grounded in a multidimensional conceptual framework, the initial 33-item pool was generated based on literature review and expert consultation. A total of 1346 students aged 12 to 18 completed the preliminary version of the scale. The sample was randomly divided for item analysis, exploratory factor analysis (EFA), and confirmatory factor analysis (CFA). Reliability was assessed using Cronbach's alpha, while validity was examined through construct validity, convergent validity, and preliminary criterion-related evidence. In addition, we employed a percentile-based method to classify adolescents' exercise habit levels according to their scale scores. RESULTS: The final AEHS consisted of 12 items loading on three dimensions: exercise consistency, self-motivation, and integration of exercise into daily life. The AEHS showed acceptable internal consistency, content validity, convergent validity and criterion-related validity (Cronbach's alpha ranged from 0.705 to 0.855, CVI values ranged from 0.79 to 0.87, AVE values ranged from 0.378 to 0.603, and correlation coefficients ranged from 0.564 to 0.659). The AEHS also enables the classification of adolescents' exercise habits into low, moderate, and high levels based on their total scores. CONCLUSIONS: Overall, the AEHS appears to be a valid and reliable tool for evaluating adolescent exercise habits in Chinese contexts and may contribute to more targeted interventions in physical activity promotion. FAU - Wu, Jin AU - Wu J AD - Department of Physical Education, Zhejiang Wanli University, 8 Qianhu South Road, Ningbo, 315100, China. FAU - Yu, Huasen AU - Yu H AD - School of Physical Education, Qinghai Normal University, 38 Haihu Avenue, Xining, 810008, China. FAU - Li, Liqing AU - Li L AD - School of Physical Education, Xizang Minzu University, 6 Wenhui East Road, Xianyang, 712082, China. FAU - Yang, Yuhang AU - Yang Y AD - Department of Physical Education, College of Education, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China. FAU - Zhang, Zeyang AU - Zhang Z AD - College of Physical Education and Health, East China Normal University, 500 Jianchuan Road, Shanghai, 200241, China. FAU - Hu, Xiaopan AU - Hu X AD - Faculty of Sports Science, Ningbo University, 818 Fenghua Road, Ningbo, 315211, China. FAU - Tuerdi, Zufeiya AU - Tuerdi Z AD - Institute of Physical Education, Xinjiang Normal University, 102 Xinyi Road, Urumqi, Shayibake District, 830054, China. 404460296@qq.com. LA - eng GR - 25CTY030/National Social Science Foundation of China/ PT - Journal Article PT - Validation Study DEP - 20251202 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Adolescent MH - *Exercise/psychology MH - Female MH - Psychometrics MH - Reproducibility of Results MH - Child MH - Male MH - China MH - Surveys and Questionnaires/standards MH - *Adolescent Behavior/psychology MH - *Habits PMC - PMC12777359 OTO - NOTNLM OT - Adolescents OT - Consistency OT - Daily-life integration OT - Exercise habits OT - Scale development OT - Self-motivation COIS- Declarations. Ethics approval and consent to participate: This scale development study is conducted in compliance with the ethical principles of the 1964 Declaration of Helsinki and its later amendments. The recruitment of participants in this study was approved by the Ethics Review Committee of East China Normal University (protocol number: HR 206-2024). School administrators and parents/legal guardians were informed in advance about the study's purpose, procedures, and voluntary nature. Written informed consent was obtained from all the participants involved in the study. Written informed consent was obtained from all parents/guardians. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/03 01:16 MHDA- 2026/06/27 06:47 PMCR- 2025/12/02 CRDT- 2025/12/02 23:55 PHST- 2025/06/27 00:00 [received] PHST- 2025/11/24 00:00 [accepted] PHST- 2026/06/27 06:47 [medline] PHST- 2025/12/03 01:16 [pubmed] PHST- 2025/12/02 23:55 [entrez] PHST- 2025/12/02 00:00 [pmc-release] AID - 10.1186/s12889-025-25818-y [pii] AID - 25818 [pii] AID - 10.1186/s12889-025-25818-y [doi] PST - epublish SO - BMC Public Health. 2025 Dec 2;26(1):82. doi: 10.1186/s12889-025-25818-y. PMID- 41329746 OWN - NLM STAT- MEDLINE DCOM- 20251202 LR - 20251205 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 12 DP - 2025 TI - Modifiable risk factors for inflammatory bowel disease in Kuwait: A cross-sectional analysis. PG - e0338005 LID - 10.1371/journal.pone.0338005 [doi] LID - e0338005 AB - Inflammatory bowel disease (IBD), a lifelong inflammatory condition of the gastrointestinal tract, is influenced by complex interactions between genetics and environmental exposures. While IBD rates have increased globally, largely due to Westernized lifestyle shifts, the contributors to IBD in Kuwait remain poorly understood. This cross-sectional study aimed to explore lifestyle, dietary, and occupational exposures associated with IBD in this unique population. A total of 520 adults (412 with IBD and 108 without IBD) completed a 40-item online questionnaire assessing early-life, lifestyle, occupational, and dietary exposures. Of the IBD participants, 174 had ulcerative colitis (UC) and 238 had Crohn's disease (CD). The questionnaire was adapted from a previously validated tool, but was not formally validated in the Kuwaiti population. Associations between these factors and IBD status were analyzed using multivariable logistic regression with adjusted odds ratios (AORs) and 95% confidence intervals (CIs) reported after adjusting for potential confounders. Factors associated with increased odds of IBD included male sex (AOR = 2.487, p = 0.005), younger age (AOR = 0.964, p = 0.004), positive family history (AOR = 2.141, p = 0.023), mentally demanding jobs (AOR = 1.818, p = 0.039), alcohol consumption (AOR = 6.508, p = 0.016), frequent spicy food intake 1-2 times/week (AOR = 2.631, p = 0.008), and prior parasitic infection (AOR = 0.484, p = 0.042). A history of appendectomy was also associated (AOR = 7.158, p = 0.003). Several modifiable exposures were found to be associated with IBD status in Kuwait. These findings underscore the multifactorial nature of IBD. However, the cross-sectional design, reliance on self-reporting, and use of a non-validated instrument limit causal interpretation. Future longitudinal research is needed to better understand temporal relationships. CI - Copyright: (c) 2025 Alhasan, Alshatti. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Alhasan, Reem AU - Alhasan R AUID- ORCID: 0000-0003-1718-7599 AD - Faculty of Public Health, Department of Environmental and Occupational Health, Kuwait University, Kuwait, Kuwait. FAU - Alshatti, Talal AU - Alshatti T AD - Faculty of Allied Health Sciences, Department of Physiotherapy, Kuwait University, Kuwait, Kuwait. LA - eng PT - Journal Article DEP - 20251202 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Kuwait/epidemiology MH - Male MH - Female MH - Cross-Sectional Studies MH - Adult MH - Risk Factors MH - Middle Aged MH - Surveys and Questionnaires MH - *Inflammatory Bowel Diseases/epidemiology/etiology MH - Life Style MH - *Crohn Disease/epidemiology/etiology MH - Young Adult MH - *Colitis, Ulcerative/epidemiology/etiology MH - Diet MH - Occupational Exposure/adverse effects MH - Adolescent MH - Odds Ratio PMC - PMC12671769 COIS- The authors have declared that no competing interests exist. EDAT- 2025/12/02 19:15 MHDA- 2025/12/02 19:16 PMCR- 2025/12/02 CRDT- 2025/12/02 13:43 PHST- 2025/08/16 00:00 [received] PHST- 2025/11/17 00:00 [accepted] PHST- 2025/12/02 19:16 [medline] PHST- 2025/12/02 19:15 [pubmed] PHST- 2025/12/02 13:43 [entrez] PHST- 2025/12/02 00:00 [pmc-release] AID - PONE-D-25-43895 [pii] AID - 10.1371/journal.pone.0338005 [doi] PST - epublish SO - PLoS One. 2025 Dec 2;20(12):e0338005. doi: 10.1371/journal.pone.0338005. eCollection 2025. PMID- 41326635 OWN - NLM STAT- MEDLINE DCOM- 20260108 LR - 20260111 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2025 Dec 1 TI - Influence of short video usage on adolescent's learning strategies: investigation on teenagers in HeBei North China. PG - 1050 LID - 10.1038/s41598-025-30713-y [doi] LID - 1050 AB - The proliferation of digital devices has led to increased screen time among adolescents, raising concerns about its impact on health, development, and academic performance. This study aimed to investigate the current state of digital screen time associated with short-videos among adolescents, analyze learning strategies across different demographic groups, and evaluate the influence of short-videos on adolescents' daily lives and learning strategies. A quantitative validation study was conducted with 4515 participants from 18 schools in HeBei province. Data were collected through a questionnaire that included demographic information, reasons for watching short-videos, and Zhang Yeheng's Learning Strategy Scale. Statistical analysis was performed using SPSSAU software, with non-parametric tests to compare groups. After removing invalid questionnaires, 3028 valid responses were analyzed. Middle school students scored higher in learning strategies than high school students. Participants who owned mobile phones and used these devices primarily on weekends had higher learning strategy scores. Conversely, increased daily screen time was associated with lower learning strategy scores. Short-video usage has a complex impact on adolescent learning strategies. While providing informational resources, excessive use may distract and impair learning outcomes. Collaborative efforts from families, schools, and society are needed to guide healthy short-video usage for adolescents' learning development. CI - (c) 2025. The Author(s). FAU - Ziye, Liu AU - Ziye L AD - Medical Technology College, HeBei Medical University, No.316 Zhong'shan E Rd, Shijiazhuang, 050017, HeBei, China. FAU - Yuying, Zhao AU - Yuying Z AD - Department of Cardiology, No.980 Hospital of PLA Joint Logistics Support Force, No.398 Zhong'shan W Rd, Shijiazhuang, 050082, HeBei, China. FAU - Ziyuan, Mao AU - Ziyuan M AD - Medical Technology College, HeBei Medical University, No.316 Zhong'shan E Rd, Shijiazhuang, 050017, HeBei, China. FAU - Zhimin, Han AU - Zhimin H AD - Academic Affairs Office, The Second Hospital of HeBei Medical University, No.215 Heping W Rd, Shijiazhuang, 050000, HeBei, China. hanzhimin2025@163.com. FAU - Xinhua, Li AU - Xinhua L AD - Medical Technology College, HeBei Medical University, No.316 Zhong'shan E Rd, Shijiazhuang, 050017, HeBei, China. LA - eng PT - Journal Article DEP - 20251201 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - China MH - *Learning MH - Surveys and Questionnaires MH - Students/psychology MH - *Screen Time MH - *Adolescent Behavior/psychology MH - Schools PMC - PMC12783838 OTO - NOTNLM OT - Adolescent OT - Digital screen time OT - Learning strategies OT - Short-video usage COIS- Declarations. Competing interests: The authors have declared that no competing interests exist. Ethics Statement: The current study was approved by the Research Ethics Committee of the Second Hospital of HeBei Medical University (No.2024-R758). After obtaining consent from the guardian via telephone, the informed consent form was included in the surveylink. Participants who agreed to the informed consent continued to complete the questionnaire, while those who did not agree exited the survey link. EDAT- 2025/12/02 01:00 MHDA- 2026/01/09 00:26 PMCR- 2025/12/01 CRDT- 2025/12/01 23:29 PHST- 2025/07/27 00:00 [received] PHST- 2025/11/26 00:00 [accepted] PHST- 2026/01/09 00:26 [medline] PHST- 2025/12/02 01:00 [pubmed] PHST- 2025/12/01 23:29 [entrez] PHST- 2025/12/01 00:00 [pmc-release] AID - 10.1038/s41598-025-30713-y [pii] AID - 30713 [pii] AID - 10.1038/s41598-025-30713-y [doi] PST - epublish SO - Sci Rep. 2025 Dec 1;16(1):1050. doi: 10.1038/s41598-025-30713-y. PMID- 41326443 OWN - NLM STAT- MEDLINE DCOM- 20251201 LR - 20260911 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Dec 1 TI - Development and validation of peaters choice, an intervention module for healthcare practitioners in managing picky eating among children aged 3-5 years. PG - 42878 LID - 10.1038/s41598-025-26949-3 [doi] LID - 42878 AB - Picky eating (PE) during early childhood is a growing concern, often linked to poor dietary intake and increased parental stress. While healthcare professionals (HCPs) are well-positioned to assist, there remains a lack of structured, evidence-based modules to guide PE management in public health settings. This research aim to develop a validated healthy eating intervention module for HCPs in managing picky eaters (PEaters Choice). The module development followed the first three phases of the ADDIE instructional design model: Analysis, Design, and Development. Phase 1 (Analysis) involved a scoping review, a quantitative, and qualitative study, while Phase 2 (Design) focused on designing the module content and aligning activities with relevant theoretical frameworks. In Phase 3 (Development), nine experts evaluated the newly developed module using face and content validity forms. Findings from Phases 1 and 2 informed a multidisciplinary module design, guiding its objectives, content, and delivery based on evidence and stakeholder input. In general, the PEaters Choice module surpassed established benchmarks, achieving high validity scores (> 80%) and S-CVI/Ave (> 0.80). Face validity results also confirmed the module's relevance, clarity of instruction, and alignment with its intended objectives of empowering HCPs to effectively manage pediatric PE in the public health setting. The PEaters Choice module demonstrates strong preliminary validity and offers a structured tool to assist HCPs in managing PE among children. While implementation and impact evaluation remain future steps, the current version provides a foundation for broader application and potential to empower both HCPs and parents. CI - (c) 2025. The Author(s). FAU - Kamarudin, Mohd Shah AU - Kamarudin MS AD - Faculty of Sports Science and Recreation, University Teknologi MARA Perlis, Arau, 02600, Malaysia. FAU - Hamzaid, Nur Hana AU - Hamzaid NH AD - Center for Rehabilitation & Special Need Studies (iCaRehab), Faculty of Health Sciences, Universiti Kebangsaan Malaysia Kuala Lumpur Campus, Kuala Lumpur, 50300, Malaysia. hanahamzaid@ukm.edu.my. FAU - Shahril, Mohd Razif AU - Shahril MR AD - Center for Healthy Ageing & Wellness (H-CARE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia Kuala Lumpur Campus, Kuala Lumpur, 50300, Malaysia. FAU - Haron, Hasnah AU - Haron H AD - Center for Healthy Ageing & Wellness (H-CARE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia Kuala Lumpur Campus, Kuala Lumpur, 50300, Malaysia. FAU - Kadar, Masne AU - Kadar M AD - Center for Rehabilitation & Special Need Studies (iCaRehab), Faculty of Health Sciences, Universiti Kebangsaan Malaysia Kuala Lumpur Campus, Kuala Lumpur, 50300, Malaysia. FAU - Safii, Nik Shanita AU - Safii NS AD - Center for Community Health Studies (ReaCH), Faculty of Health Sciences, Universiti Kebangsaan Malaysia Kuala Lumpur Campus, Kuala Lumpur, 50300, Malaysia. LA - eng GR - FRGS/1/2021/SKK06/UKM/03/3/Ministry of Higher Education, Malaysia/ GR - FRGS/1/2021/SKK06/UKM/03/3/Ministry of Higher Education, Malaysia/ GR - FRGS/1/2021/SKK06/UKM/03/3/Ministry of Higher Education, Malaysia/ GR - FRGS/1/2021/SKK06/UKM/03/3/Ministry of Higher Education, Malaysia/ GR - FRGS/1/2021/SKK06/UKM/03/3/Ministry of Higher Education, Malaysia/ GR - FRGS/1/2021/SKK06/UKM/03/3/Ministry of Higher Education, Malaysia/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251201 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Child, Preschool MH - *Health Personnel/education MH - Female MH - Male MH - *Food Preferences/psychology MH - *Feeding Behavior MH - *Choice Behavior MH - Diet, Healthy PMC - PMC12669771 OTO - NOTNLM OT - Education OT - Intervention module OT - Module development and validity module OT - Parenting OT - Picky eaters OT - Sensory COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/12/02 01:00 MHDA- 2025/12/02 01:01 PMCR- 2025/12/01 CRDT- 2025/12/01 23:20 PHST- 2024/06/10 00:00 [received] PHST- 2025/10/31 00:00 [accepted] PHST- 2025/12/02 01:01 [medline] PHST- 2025/12/02 01:00 [pubmed] PHST- 2025/12/01 23:20 [entrez] PHST- 2025/12/01 00:00 [pmc-release] AID - 10.1038/s41598-025-26949-3 [pii] AID - 26949 [pii] AID - 10.1038/s41598-025-26949-3 [doi] PST - epublish SO - Sci Rep. 2025 Dec 1;15(1):42878. doi: 10.1038/s41598-025-26949-3. PMID- 41326038 OWN - NLM STAT- MEDLINE DCOM- 20251201 LR - 20251223 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 9 IP - 1 DP - 2025 Nov 30 TI - Association between maternal mental health and child nutritional status in rural Sindh: a cross-sectional study using an e-health clinical model. LID - 10.1136/bmjpo-2025-003972 [doi] LID - e003972 AB - OBJECTIVE: To assess the association between maternal common mental disorders (CMD), as measured by the Self-Reporting Questionnaire-20 (SRQ-20), and child nutritional outcomes wasting, stunting and underweight in rural Sindh, Pakistan, using an e-health clinical model. DESIGN: A cross-sectional observational study was conducted to explore the relationship between maternal mental health and child nutritional status. Data were collected through nurse-facilitated consultations at e-health clinics, with maternal CMD assessed via the WHO-validated SRQ-20 tool and child nutritional status measured using standardised anthropometric indicators (weight-for-height Z-score, height-for-age Z-score, weight-for-age Z-score) based on WHO growth standards. Multivariate logistic regression was applied to determine adjusted associations. SETTING: Six nurse-assisted e-health clinics operating under the Sehat Kahani telemedicine platform across rural regions of Sindh. PARTICIPANTS: A total of 455 mother-child dyads with children aged 6-59 months who visited clinics between April and June 2025. Eligible mothers had resided in the local area for 6 months and were not undergoing treatment for any mental health disorder. RESULTS: Stunting affected 62% of children, underweight 46.8% and wasting 43.3%. Maternal CMD was prevalent in 76.9% of participants (SRQ-20 score >/=7). Multivariate logistic regression revealed that children of mothers with CMD were about twice as likely to be stunted (adjusted odds ratio (AOR)=2.006, p=0.006) and nearly 1.6 times more likely to be underweight (AOR=1.688, p=0.05), though CMD showed no link with wasting. Maternal education was protective against stunting (AOR=0.458, p=0.012), while paternal unemployment was linked to increased odds of stunting and underweight. No significant associations were found with environmental factors, water source and toilet facilities. CONCLUSION: Maternal CMD, educational attainment and paternal employment status are key predictors of child nutritional status in rural, low-resource contexts. These findings underscore the need for integrated maternal mental health and child nutrition interventions within digital healthcare delivery models. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Muzzamil, Muhammad AU - Muzzamil M AUID- ORCID: 0000-0001-9871-5837 AD - Public Health and Digital Health, Sehat Kahani, Karachi, Sindh, Pakistan muzzamilrao21@gmail.com. AD - Public Health, Health Services Academy, Islamabad, Punjab, Pakistan. FAU - Khurram, Sara Saeed AU - Khurram SS AD - Public Health and Digital Health, Sehat Kahani, Karachi, Sindh, Pakistan. FAU - Aga, Iffat Zafar AU - Aga IZ AD - Public Health and Digital Health, Sehat Kahani, Karachi, Sindh, Pakistan. FAU - Karim, Mahek AU - Karim M AD - Public Health and Digital Health, Sehat Kahani, Karachi, Sindh, Pakistan. FAU - Fatima, Farwa AU - Fatima F AUID- ORCID: 0009-0003-8023-026X AD - Public Health, SZABIST, Karachi, Pakistan. FAU - Hashmi, Shahkamal AU - Hashmi S AD - College of Public Health, Ziauddin University, Karachi, Sindh, Pakistan. LA - eng PT - Journal Article PT - Observational Study DEP - 20251130 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Child, Preschool MH - *Nutritional Status MH - Infant MH - Rural Population/statistics & numerical data MH - Male MH - *Mental Disorders/epidemiology MH - Adult MH - Pakistan/epidemiology MH - *Mothers/psychology MH - *Growth Disorders/epidemiology MH - Telemedicine MH - *Maternal Health MH - *Child Nutrition Disorders/epidemiology MH - Thinness/epidemiology MH - *Mental Health PMC - PMC12684096 OTO - NOTNLM OT - Child Health OT - Developing Countries OT - Health services research OT - Low and Middle Income Countries OT - Noncommunicable Diseases COIS- Competing interests: No, there are no competing interests. EDAT- 2025/12/02 01:00 MHDA- 2025/12/02 01:01 PMCR- 2025/11/30 CRDT- 2025/12/01 20:52 PHST- 2025/08/11 00:00 [received] PHST- 2025/11/16 00:00 [accepted] PHST- 2025/12/02 01:01 [medline] PHST- 2025/12/02 01:00 [pubmed] PHST- 2025/12/01 20:52 [entrez] PHST- 2025/11/30 00:00 [pmc-release] AID - 10.1136/bmjpo-2025-003972 [pii] AID - bmjpo-2025-003972 [pii] AID - 10.1136/bmjpo-2025-003972 [doi] PST - epublish SO - BMJ Paediatr Open. 2025 Nov 30;9(1):e003972. doi: 10.1136/bmjpo-2025-003972. PMID- 41324694 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20261010 IS - 1436-6215 (Electronic) IS - 1436-6207 (Linking) VI - 64 IP - 8 DP - 2025 Dec 1 TI - Development and validation of a multicriteria measure to assess the sustainability characteristics of diets: the Diet Sustainability Score. PG - 328 LID - 10.1007/s00394-025-03844-1 [doi] AB - PURPOSE: This cross-sectional study aims to develop and validate the Diet Sustainability Score (DSS), a multicriteria measure designed to evaluate the sustainability of diets by integrating nutritional, environmental, economic, and sociocultural dimensions. METHODS: Dietary data from 2287 adults (18 + years) who completed two non-consecutive 24-h dietary recalls during the National Food, Nutrition, and Physical Activity Survey (IAN-AF 2015/2016) were used to assess the psychometric properties of the DSS. Content validity was assessed through expert evaluation. Reproducibility was tested using the intraclass correlation coefficient (ICC), and construct validity was examined by testing conceptually derived hypotheses. RESULTS: The DSS demonstrated robust content validity through expert assessment and alignment with established frameworks. Reproducibility was supported by an ICC of 0.407 and construct validity by confirming 78% of conceptually derived hypotheses. The DSS showed positive associations with females, older ages, higher education, and higher income, as well as healthier lifestyle behaviours, including non-smoking, non-alcohol consumption, greater organic food intake, and less frequent eating out-of-home habits. Participants with higher DSS consumed more vegetables, fruits, fish, white meat, and olive oil and less red and processed meat, sweets, and salty snacks, aligning with Portuguese Mediterranean dietary guidelines. CONCLUSION: The DSS effectively captures the multidimensional nature of sustainable diets, offering a reliable tool for research and policy to promote more sustainable eating practices. FAU - Rei, Mariana AU - Rei M AUID- ORCID: 0000-0001-8945-3708 AD - Faculdade de Ciencias da Nutricao e Alimentacao, Universidade do Porto, Rua do Campo Alegre 823, 4150-180, Porto, Portugal. AD - EPIUnit - Instituto de Saude Publica, Universidade do Porto, 4050-600, Porto, Portugal. AD - Laboratorio para a Investigacao Integrativa e Translacional em Saude Populacional (ITR), Universidade do Porto, 4050-600, Porto, Portugal. AD - Faculdade de Medicina, Universidade do Porto, 4200-319, Porto, Portugal. FAU - Silva, Catarina Campos AU - Silva CC AUID- ORCID: 0009-0001-4146-9070 AD - Faculdade de Medicina, Universidade do Porto, 4200-319, Porto, Portugal. FAU - Torres, Duarte AU - Torres D AUID- ORCID: 0000-0001-8960-2160 AD - Faculdade de Ciencias da Nutricao e Alimentacao, Universidade do Porto, Rua do Campo Alegre 823, 4150-180, Porto, Portugal. AD - EPIUnit - Instituto de Saude Publica, Universidade do Porto, 4050-600, Porto, Portugal. AD - Laboratorio para a Investigacao Integrativa e Translacional em Saude Populacional (ITR), Universidade do Porto, 4050-600, Porto, Portugal. FAU - Sage, Colin AU - Sage C AUID- ORCID: 0000-0002-2063-4815 AD - Faculdade de Ciencias da Nutricao e Alimentacao, Universidade do Porto, Rua do Campo Alegre 823, 4150-180, Porto, Portugal. FAU - Rodrigues, Sara AU - Rodrigues S AUID- ORCID: 0000-0003-0647-5018 AD - Faculdade de Ciencias da Nutricao e Alimentacao, Universidade do Porto, Rua do Campo Alegre 823, 4150-180, Porto, Portugal. saraspr@fcna.up.pt. AD - EPIUnit - Instituto de Saude Publica, Universidade do Porto, 4050-600, Porto, Portugal. saraspr@fcna.up.pt. AD - Laboratorio para a Investigacao Integrativa e Translacional em Saude Populacional (ITR), Universidade do Porto, 4050-600, Porto, Portugal. saraspr@fcna.up.pt. LA - eng GR - 2021.04955.BD/FCT - Fundacao para a Ciencia e Tecnologia, I.P./ GR - https://doi.org/10.54499/LA/P/0064/2020/FCT - Fundacao para a Ciencia e Tecnologia, I.P./ GR - https://doi.org/10.54499/UIDB/04750/2020/FCT - Fundacao para a Ciencia e Tecnologia, I.P./ GR - PT06-000088SI3/EEA Grants Program, Public Health Initiatives/ PT - Journal Article PT - Validation Study DEP - 20251201 PL - Germany TA - Eur J Nutr JT - European journal of nutrition JID - 100888704 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Adult MH - Reproducibility of Results MH - Middle Aged MH - *Diet/statistics & numerical data/methods MH - Male MH - Young Adult MH - *Nutrition Surveys/methods MH - Psychometrics MH - *Diet Surveys/methods MH - Adolescent MH - Aged MH - Feeding Behavior MH - *Diet, Healthy/statistics & numerical data MH - Portugal OTO - NOTNLM OT - 24-h recalls OT - Adults OT - Dietary data OT - Multicriteria analysis OT - Sustainability score OT - Sustainable diets COIS- Declarations. Conflict of interest: The authors report that there are no competing interests to declare. Ethical approval: This research involved additional processing of previously collected personal data from the IAN-AF that had previously obtained ethical approval from the National Commission for Data Protection, the Ethical Committee of the Institute of Public Health of the University of Porto, and the Ethical Commissions of each of the Regional Administration of Health. All participants were asked to provide their written informed consent for participation according to the Ethical Principles for Medical Research involving human subjects expressed in the Declaration of Helsinki and the national legislation. Moreover, this study utilized a pseudo-anonymized database of IAN-AF. EDAT- 2025/12/01 12:29 MHDA- 2026/06/27 06:43 CRDT- 2025/12/01 11:16 PHST- 2025/06/26 00:00 [received] PHST- 2025/10/30 00:00 [accepted] PHST- 2026/06/27 06:43 [medline] PHST- 2025/12/01 12:29 [pubmed] PHST- 2025/12/01 11:16 [entrez] AID - 10.1007/s00394-025-03844-1 [pii] AID - 10.1007/s00394-025-03844-1 [doi] PST - epublish SO - Eur J Nutr. 2025 Dec 1;64(8):328. doi: 10.1007/s00394-025-03844-1. PMID- 41322661 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251201 LR - 20251203 IS - 2211-3355 (Print) IS - 2211-3355 (Electronic) IS - 2211-3355 (Linking) VI - 60 DP - 2025 Dec TI - Implementation of the whole school, whole community, whole child model in Makkah schools, Saudi Arabia: association with students' body mass index and academic achievement. PG - 103308 LID - 10.1016/j.pmedr.2025.103308 [doi] LID - 103308 AB - OBJECTIVE: To assess the implementation of the Whole School, Whole Community, Whole Child (WSCC) model in public elementary schools in Makkah, Saudi Arabia, and examine its association with students' body mass index (BMI) and academic achievement. METHODS: A cross-sectional study was conducted in 2022 across 20 elementary schools in Makkah using multistage cluster sampling. Participants included 385 students and 32 school staff from health-promoting schools (HPSs) and non-HPSs. Implementation of four WSCC domains; community involvement, family engagement, physical environment, and counseling services, was assessed using validated self-administered questionnaires. Academic scores, BMI, and sociodemographic data were collected. Data analysis utilized descriptive statistics, bivariate tests, Spearman correlations, and multivariable linear regression. RESULTS: Students in HPSs reported higher WSCC implementation and academic achievement than those in non-HPSs (median score: 687 vs. 665, p = 0.009). In multivariable models, WSCC implementation remained an independent predictor of academic achievement after adjustment (B = 1.63, 95 % CI: 0.90, 2.35), whereas its association with BMI was not significant (B = 0.36, 95 % CI: -0.32, 1.04). A dual burden of underweight and overweight was observed. CONCLUSIONS: Strengthening WSCC implementation, especially mental health support, family and community engagement, and equitable policy adoption, may enhance students' learning and well-being. CI - (c) 2025 Published by Elsevier Inc. FAU - Nour, Mohamed O AU - Nour MO AD - Department of Health Promotion and Education, College of Public Health & Health Informatics, Umm Al-Qura University, Makkah, Saudi Arabia. LA - eng PT - Journal Article DEP - 20251108 PL - United States TA - Prev Med Rep JT - Preventive medicine reports JID - 101643766 PMC - PMC12663021 OTO - NOTNLM OT - Academic achievement OT - BMI OT - Health-promoting school OT - Makkah OT - Non-health-promoting school OT - WSCC model COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/12/01 12:28 MHDA- 2025/12/01 12:29 PMCR- 2025/11/08 CRDT- 2025/12/01 06:27 PHST- 2025/08/21 00:00 [received] PHST- 2025/11/06 00:00 [revised] PHST- 2025/11/07 00:00 [accepted] PHST- 2025/12/01 12:29 [medline] PHST- 2025/12/01 12:28 [pubmed] PHST- 2025/12/01 06:27 [entrez] PHST- 2025/11/08 00:00 [pmc-release] AID - S2211-3355(25)00347-X [pii] AID - 103308 [pii] AID - 10.1016/j.pmedr.2025.103308 [doi] PST - epublish SO - Prev Med Rep. 2025 Nov 8;60:103308. doi: 10.1016/j.pmedr.2025.103308. eCollection 2025 Dec. PMID- 41320165 OWN - NLM STAT- MEDLINE DCOM- 20260201 LR - 20260201 IS - 1678-4782 (Electronic) IS - 0021-7557 (Print) IS - 0021-7557 (Linking) VI - 102 IP - 1 DP - 2026 Jan-Feb TI - Clinical characteristics and gaps in palliative care among tracheostomized children: a retrospective observational study. PG - 101480 LID - S0021-7557(25)00168-8 [pii] LID - 10.1016/j.jped.2025.101480 [doi] LID - 101480 AB - OBJECTIVE: To describe the clinical characteristics of tracheostomized children in Northeastern Brazil and to identify existing gaps in the indication and implementation of palliative care. METHODS: This retrospective descriptive study reviewed medical records of children under 15 years who underwent tracheostomy between 2008 and 2019 at a quaternary referral center. RESULTS: Sixty-five tracheostomized patients with indications for palliative care were analyzed. The main reasons for palliative classification were acute life-threatening conditions (50.7 %) and chronic life-threatening conditions (20 %). The most frequent tracheostomy indications were prolonged invasive mechanical ventilation (46.1 %) and severe upper airway obstruction (23 %). The mortality rate was 30.7 %, higher among infants, severely malnourished children, those with Lansky scores below 40 % before tracheostomy, congenital heart disease, bronchopulmonary dysplasia, and multiple comorbidities. Only 10.8 % received palliative care consultations during hospitalization, all in the end-of-life care phase. CONCLUSIONS: The results highlight a critical gap in the provision of palliative care to tracheostomized children. Early involvement of a multidisciplinary palliative care team is crucial to support clinical decision-making, family-centered care, and ensure quality of life. The proposed framework may facilitate timely referral and airway planning in the Intensive therapy, although further validation and qualitative research in various healthcare settings are needed. CI - Copyright (c) 2025 The Authors. Published by Elsevier Espana S.L.U. All rights reserved. FAU - Luna, Luziane Lais Sabino Silva AU - Luna LLSS AD - Instituto de Medicina Integral Prof. Fernando Figueira - IMIP, Recife, PE, Brazil. Electronic address: luziane.sabino@gmail.com. FAU - Duarte, Maria do Carmo Menezes Bezerra AU - Duarte MDCMB AD - Instituto de Medicina Integral Prof. Fernando Figueira - IMIP, Recife, PE, Brazil. FAU - Levy, Sheyla Suelle Dos Santos AU - Levy SSDS AD - Instituto de Medicina Integral Prof. Fernando Figueira - IMIP, Recife, PE, Brazil. FAU - Lima, Luciana Santana AU - Lima LS AD - Instituto de Medicina Integral Prof. Fernando Figueira - IMIP, Recife, PE, Brazil. LA - eng PT - Journal Article PT - Observational Study DEP - 20251212 PL - Brazil TA - J Pediatr (Rio J) JT - Jornal de pediatria JID - 2985188R SB - IM MH - Humans MH - *Palliative Care/statistics & numerical data MH - Retrospective Studies MH - *Tracheostomy/statistics & numerical data/mortality MH - Infant MH - Child, Preschool MH - Male MH - Child MH - Female MH - Brazil MH - Adolescent MH - Infant, Newborn MH - Quality of Life PMC - PMC12765322 OTO - NOTNLM OT - Children OT - Palliative care OT - Tracheostomy COIS- Conflicts of interest The authors declare no conflicts of interest. EDAT- 2025/12/01 00:30 MHDA- 2026/02/02 00:29 PMCR- 2025/12/12 CRDT- 2025/11/30 19:20 PHST- 2025/07/10 00:00 [received] PHST- 2025/10/31 00:00 [revised] PHST- 2025/10/31 00:00 [accepted] PHST- 2026/02/02 00:29 [medline] PHST- 2025/12/01 00:30 [pubmed] PHST- 2025/11/30 19:20 [entrez] PHST- 2025/12/12 00:00 [pmc-release] AID - S0021-7557(25)00168-8 [pii] AID - 101480 [pii] AID - 10.1016/j.jped.2025.101480 [doi] PST - ppublish SO - J Pediatr (Rio J). 2026 Jan-Feb;102(1):101480. doi: 10.1016/j.jped.2025.101480. Epub 2025 Dec 12. PMID- 41319348 OWN - NLM STAT- MEDLINE DCOM- 20251211 LR - 20251211 IS - 1879-0739 (Electronic) IS - 0271-5317 (Linking) VI - 144 DP - 2025 Dec TI - Evening chronotype, irregular circadian eating patterns, and eating-related behaviors may be associated with increased obesity risk among Turkish university students: A large-scale cross-sectional study. PG - 74-87 LID - S0271-5317(25)00136-8 [pii] LID - 10.1016/j.nutres.2025.11.002 [doi] AB - This study investigated the interplay between chronotype, chrononutritional indices, diet quality, eating behaviors, circadian rhythm variables, and obesity indicators in university students. Specifically, in this cross-sectional study, 618 healthy students from Erciyes University completed validated questionnaires assessing chronotype (Morningness-Eveningness Questionnaire, MEQ), Mediterranean diet adherence (Mediterranean Diet Adherence Screener, MEDAS), hedonic hunger (Power of Food Scale, PFS), eating awareness (Mindful Eating Inventory, MEI), and chrononutritional variables. Furthermore, associations were evaluated using ANCOVA, partial correlations, and multiple regression analyses. Results indicated that morning types demonstrated higher MEDAS and MEI scores, more frequent breakfast consumption, lower eating and social jetlag than evening types; while evening types had a shorter eating window than intermediate types (all P < .05). Moreover, greater eating jetlag was associated with longer eating windows, more frequent breakfast consumption, higher social jetlag, and shorter sleep (all P < .001). In addition, multivariable models showed that MEI scores were inversely associated with waist circumference (beta = -0.104, P < .001), waist-to-hip ratio (beta = -0.074, P = .013), and body mass index (beta = -0.156, P < .001). Conversely, PFS scores were positively correlated with anthropometric indicators of obesity, while MEI scores were inversely associated with these measures (all P < .05). Taken together, evening chronotype, irregular meal timing, and predominantly lower eating awareness were independently linked to poorer dietary patterns, adverse eating behaviors, and increased obesity risk in young adults. Thus, promoting morning-oriented eating, regular meals, and mindful eating may improve metabolic health in this population. CI - Copyright (c) 2025 Elsevier Inc. All rights reserved. FAU - Ilkay, Hatice Ozcaliskan AU - Ilkay HO AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Erciyes University, Melikgazi, Kayseri, Turkey. Electronic address: ozcaliskan@erciyes.edu.tr. LA - eng PT - Journal Article DEP - 20251105 PL - United States TA - Nutr Res JT - Nutrition research (New York, N.Y.) JID - 8303331 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Male MH - *Feeding Behavior MH - *Circadian Rhythm MH - *Obesity/etiology/epidemiology MH - *Students MH - Universities MH - Young Adult MH - Turkey/epidemiology MH - Adult MH - Surveys and Questionnaires MH - Diet, Mediterranean MH - Sleep MH - Waist Circumference MH - Breakfast MH - Risk Factors MH - Diet MH - Body Mass Index MH - Hunger MH - Adolescent MH - Chronotype OTO - NOTNLM OT - Chrononutrition OT - Chronotype OT - Eating behavior OT - Hedonic hunger OT - Mindful eating OT - Obesity OT - Young adults COIS- Author declarations None. EDAT- 2025/11/30 19:31 MHDA- 2025/12/12 03:28 CRDT- 2025/11/30 17:59 PHST- 2025/08/27 00:00 [received] PHST- 2025/11/03 00:00 [revised] PHST- 2025/11/03 00:00 [accepted] PHST- 2025/12/12 03:28 [medline] PHST- 2025/11/30 19:31 [pubmed] PHST- 2025/11/30 17:59 [entrez] AID - S0271-5317(25)00136-8 [pii] AID - 10.1016/j.nutres.2025.11.002 [doi] PST - ppublish SO - Nutr Res. 2025 Dec;144:74-87. doi: 10.1016/j.nutres.2025.11.002. Epub 2025 Nov 5. PMID- 41317077 OWN - NLM STAT- MEDLINE DCOM- 20251129 LR - 20260918 IS - 1753-4666 (Electronic) IS - 1753-4658 (Print) IS - 1753-4658 (Linking) VI - 19 DP - 2025 Jan-Dec TI - Association of age, hospitalizations, and physical activity with urinary incontinence in cystic fibrosis: a multicenter cross-sectional study. PG - 17534666251397474 LID - 10.1177/17534666251397474 [doi] LID - 17534666251397474 AB - BACKGROUND: Females with cystic fibrosis (fwCF) are at increased risk of urinary incontinence (UI), likely due to chronic coughing and elevated intra-abdominal pressure. Prevalence rates reported in the literature vary widely, and no large multicenter study has been carried out to date. OBJECTIVE: To estimate the prevalence and severity of UI in fwCF and to investigate clinical variables associated with UI. DESIGN: A multicenter, cross-sectional study conducted across 21 Italian CF centers. METHODS: UI prevalence and severity were assessed using two validated questionnaires. A multivariable fractional polynomial approach was used to select variables for inclusion in the final logistic regression model to identify relevant associations with UI. RESULTS: UI was present in 218/542 females (40.2%, 95% Confidence Interval (CI): 36.1-44.5). Among children and adolescents, the prevalence was 12/160 (7.5%, 95% CI: 4.1-13), whereas among adults it was 206/382 (53.9%, 95% CI: 48.8-59). FwCF with UI showed a BMI of 0.2 Z score higher (95% CI: 0.1-0.4) than fwCF without UI; however, the overall prevalence of UI in fwCF overweight was 41% (95% CI: 30.2-52.7) compared to 40.1% (95%CI: 35.6-44.7) in fwCF with normal weight. Age (interquartile range-odds ratio (IQR-OR) 4.19, 95% CI: 2.80-6.28), days of hospitalization (IQR-OR 1.72, 95% CI: 1.42-2.08), and physical activity (OR 0.66, 95% CI: 0.53-0.82) were the only factors statistically associated with UI. CONCLUSION: UI affects mostly adult fwCF and is associated with older age and longer hospitalization. Physical activity of ⩾150 min per week was also associated with a reduced probability of UI. FAU - Carta, Federica AU - Carta F AD - Healthcare Professions Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. FAU - Malvezzi, Anna AU - Malvezzi A AD - UOC Fibrosi Cistica, Azienda Ospedaliera Universitaria Integrata (AOUI), Verona, Italy. FAU - Innocenti, Diletta AU - Innocenti D AD - Rehabilitation Unit, Meyer Children's Hospital IRCCS, Florence, Italy. FAU - d'Ippolito, Marcella AU - d'Ippolito M AD - Centro di Riferimento Regionale per la Fibrosi Cistica dell'adulto della Campania, DAI Medicina Interna e della complessita clinica, Azienda Ospedaliero Universitaria Federico II di Napoli, Naples, Italy. FAU - Piermarini, Irene AU - Piermarini I AD - UOC Pneumologia e Fibrosi Cistica, IRCCS Ospedale Pediatrico Bambin Gesu, Rome, Italy. FAU - Retucci, Mariangela AU - Retucci M AD - Healthcare Professions Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. FAU - Colombo, Carla AU - Colombo C AD - Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy. FAU - Gambazza, Simone AU - Gambazza S AUID- ORCID: 0000-0002-6225-2989 AD - Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, Laboratory of Medical Statistics, Biometry and Epidemiology "G. A. Maccacaro", Universita degli Studi di Milano. Via Celoria 22, Milan 20133, Italy. AD - Healthcare Professions Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, via Francesco Sforza 35, Milan 20122, Italy. CN - CrISP Study Group LA - eng PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20251129 PL - England TA - Ther Adv Respir Dis JT - Therapeutic advances in respiratory disease JID - 101316317 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - *Cystic Fibrosis/epidemiology/physiopathology/complications/diagnosis MH - *Urinary Incontinence/epidemiology/physiopathology/etiology/diagnosis MH - *Hospitalization/statistics & numerical data MH - Adolescent MH - Prevalence MH - Adult MH - Child MH - Italy/epidemiology MH - Age Factors MH - Young Adult MH - Severity of Illness Index MH - Risk Factors MH - Male MH - Surveys and Questionnaires MH - Middle Aged MH - Body Mass Index MH - Logistic Models PMC - PMC12665006 OAB - How Age, Hospitalizations, and Physical Activity Are Linked to Urinary Incontinence in People with Cystic FibrosisThis study looked at how common urinary incontinence (UI) is among females with cystic fibrosis (fwCF) in Italy, and what factors might be linked to it. UI is thought to be more common in fwCF because of frequent coughing and pressure in the belly. Researchers collected data from 21 cystic fibrosis centers using two questionnaires. A total of 542 females took part. They found that 40% of fwCF had UI. It was much more common in adults (54%) than in children and teens (7.5%). Women with UI had slightly higher body mass index (BMI), but being overweight didn't seem to increase the risk compared to those with normal weight. The study found that three factors were strongly linked to UI: being older, spending more days in the hospital, and doing less physical activity. Interestingly, women who exercised more than 150 minutes per week had a lower risk of UI. This suggests that staying physically active might help prevent or reduce urinary problems in females with cystic fibrosis. In summary, urinary incontinence is common among adult females with cystic fibrosis and is linked to age and time spent in the hospital. Regular physical activity appears to offer some protection. OABL- eng OTO - NOTNLM OT - cystic fibrosis OT - epidemiology OT - urinary incontinence COIS- The authors declare that the study was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. SG received fees as a consultant for BGP Products Operations GmbH (Part of Mylan Group, CH). EDAT- 2025/11/29 12:30 MHDA- 2025/11/29 12:31 PMCR- 2025/11/29 CRDT- 2025/11/29 08:34 PHST- 2025/11/29 12:31 [medline] PHST- 2025/11/29 12:30 [pubmed] PHST- 2025/11/29 08:34 [entrez] PHST- 2025/11/29 00:00 [pmc-release] AID - 10.1177_17534666251397474 [pii] AID - 10.1177/17534666251397474 [doi] PST - ppublish SO - Ther Adv Respir Dis. 2025 Jan-Dec;19:17534666251397474. doi: 10.1177/17534666251397474. Epub 2025 Nov 29. PMID- 41316894 OWN - NLM STAT- MEDLINE DCOM- 20251129 LR - 20260826 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 1 DP - 2026 Jan TI - Women's Empowerment Dimensions and Child Stunting in Ethiopia: A Multilevel Analysis of Demographic and Health Surveys 2011-2016. PG - e70136 LID - 10.1111/mcn.70136 [doi] LID - e70136 AB - Child stunting affects 38.3% of children under five in Ethiopia as of 2016. Women's empowerment, defined through both fundamental capabilities and household decision-making authority, has emerged as a critical determinant of child nutritional outcomes. Drawing on Sen's capability approach and Kabeer's empowerment framework, we examined the associations between two distinct dimensions of women's empowerment and child stunting across Ethiopia's diverse regions. We analyzed 18,466 mother-child pairs from the 2011 and 2016 Ethiopia Demographic and Health Surveys. Validated empowerment indices were constructed using factor analysis. We employed hierarchical multilevel models as our primary specification to examine the associations between women's empowerment and child stunting across Ethiopia's 11 administrative regions. Between 2011 and 2016, stunting declined from 42.3% to 36.4%. Women's decision-making authority increased (mean score: 0.70-0.78), while capabilities remained stable (0.17- 0.16). Higher capabilities were significantly associated with lower odds of stunting (beta = -0.141, aOR = 0.87, 95% CI: 0.83, 0.91), whereas decision-making showed no association (beta = 0.013, aOR = 1.01, 95% CI: 0.98, 1.05). A significant interaction between capabilities and decision-making was observed (beta = 0.050, aOR = 1.05, 95% CI: 1.01, 1.09). Regional heterogeneity was substantial: Amhara maintained high stunting rates despite empowerment gains, while Somali saw improvements with low capabilities but increased decision-making. The study findings suggest that interventions should prioritize capability development through region-specific strategies reflecting diverse pastoral, agrarian, and urban contexts; promote multi-sectoral programs linking education and nutrition services; and develop monitoring frameworks to track both dimensions of empowerment at the regional level. CI - (c) 2025 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Mengesha, Seyoum Teffera AU - Mengesha ST AUID- ORCID: 0000-0002-6148-0605 AD - Department of Economics, College of Business and Economics, Bahir Dar University, Bahir Dar, Ethiopia. AD - Institute of Economics, Corvinus University of Budapest, Budapest, Hungary. FAU - Berde, Eva AU - Berde E AUID- ORCID: 0000-0001-5614-0801 AD - Szechenyi Istvan University, Gyor, Hungary. FAU - Zerihun Yohannes, Amare AU - Zerihun Yohannes A AUID- ORCID: 0000-0002-4503-6790 AD - Department of Disaster Risk Management & Sustainable Development, Institute of Disaster Risk Management and Food Security Studies, Bahir Dar University, Bahir Dar, Ethiopia. FAU - Remsei, Sandor AU - Remsei S AUID- ORCID: 0000-0001-8862-4544 AD - Szechenyi Istvan University, Gyor, Hungary. LA - eng PT - Journal Article PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - Ethiopia/epidemiology MH - Female MH - *Empowerment MH - *Growth Disorders/epidemiology MH - Adult MH - Multilevel Analysis MH - Child, Preschool MH - Health Surveys MH - Infant MH - *Mothers/statistics & numerical data/psychology MH - Young Adult MH - Male MH - Adolescent MH - Decision Making PMC - PMC13344139 OTO - NOTNLM OT - Ethiopia OT - child stunting OT - demographic health surveys OT - regional heterogeneity OT - women's empowerment COIS- The authors declare no conflicts of interest related to this study. EDAT- 2025/11/29 06:28 MHDA- 2025/11/29 06:29 PMCR- 2025/11/29 CRDT- 2025/11/29 05:12 PHST- 2025/09/26 00:00 [revised] PHST- 2025/03/04 00:00 [received] PHST- 2025/10/16 00:00 [accepted] PHST- 2025/11/29 06:29 [medline] PHST- 2025/11/29 06:28 [pubmed] PHST- 2025/11/29 05:12 [entrez] PHST- 2025/11/29 00:00 [pmc-release] AID - MCN70136 [pii] AID - 10.1111/mcn.70136 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Jan;22(1):e70136. doi: 10.1111/mcn.70136. PMID- 41316430 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260106 LR - 20260108 IS - 2055-0928 (Electronic) IS - 2055-0928 (Linking) VI - 12 IP - 1 DP - 2025 Nov 28 TI - Causal effects of Antenatal Care (ANC) on child malnutrition: a machine learning approach in Ethiopia and Rwanda. PG - 1 LID - 10.1186/s40795-025-01208-w [doi] LID - 1 AB - Malnutrition among children under five remains a critical public health challenge in Ethiopia and Rwanda, with nearly half of the children in this study population affected by at least one form of undernutrition. This study provides a robust causal analysis of the heterogeneous effects of Antenatal Care (ANC) on child malnutrition, as measured by the Composite Index of Anthropometric Failure (CIAF). Leveraging data from 33,737 mother-child pairs from the Demographic and Health Surveys (DHS) in Ethiopia (N = 22,668) and Rwanda (N = 11,069) across three waves (2005-2015), we employ a machine learning-based Causal Forest model. This approach was chosen specifically to overcome the limitations of traditional regression methods, allowing for the estimation of how the impact of different levels of ANC attendance varies across diverse sociodemographic and health-related subgroups. The results reveal a clear and powerful dose-response relationship. While a single ANC visit has a negligible effect, attending 2-3 visits is associated with a modest 3.5% point reduction in the risk of malnutrition. The strongest impact is seen with the completion of 4 or more visits, which is associated with an average reduction of 5.7% points (ATE: -0.057). Crucially, this average effect masks profound and policy-relevant heterogeneity. The benefits of ANC are massively amplified for the most vulnerable populations; for children in the poorer wealth quintile, 4 + ANC visits are associated with a massive 17.1% point reduction in malnutrition risk-an effect nearly three times the population average. The intervention is also particularly impactful for older mothers (aged 35-49), where it is associated with an 11.9% point risk reduction. Furthermore, the benefits of ANC are amplified by a healthier environment; for children in households with an improved water source, the associated risk reduction is a substantial 7.8% points, demonstrating a powerful synergistic effect between clinical care and public health infrastructure. The application of the Causal Forest model represents a significant advancement, moving beyond a single average effect to uncover this critical heterogeneity and identify for whom, and under what conditions, ANC is most effective. These findings provide robust causal evidence for a necessary shift away from a one-size-fits-all public health strategy. The results strongly advocate for stratified and multi-sectoral interventions. Policy and resources should be intensely focused on ensuring the most vulnerable populations-particularly the poorest households and older mothers-complete the full ANC schedule, as this is where the public health return on investment is highest. Additionally, the synergistic effect with WASH highlights the need to integrate clinical maternal health programs with investments in community-level water and sanitation infrastructure. By tailoring ANC programs and combining them with broader public health improvements, governments can develop more holistic and effective strategies to accelerate progress against child malnutrition in Ethiopia, Rwanda, and comparable high-burden contexts. CI - (c) 2025. The Author(s). FAU - Tessema, Alehegn Moges AU - Tessema AM AD - African Center of Excellence in Data Science, University of Rwanda, Kigali, Rwanda. moges.alehegn@gmail.com. FAU - Zewotir, Temesgen AU - Zewotir T AD - School of Mathematics, Statistics and Computer Sciences, University of KwaZulu- Natal, Durban, South Africa. FAU - Kabanda, Richard AU - Kabanda R AD - African Center of Excellence in Data Science, University of Rwanda, Kigali, Rwanda. LA - eng PT - Journal Article DEP - 20251128 PL - England TA - BMC Nutr JT - BMC nutrition JID - 101672434 PMC - PMC12771955 OTO - NOTNLM OT - 5-fold Cross-Validation OT - Antenatal care (ANC) OT - Causal forest model OT - Child malnutrition OT - Composite index of anthropometric failure (CIAF) OT - Heterogeneous treatment effects OT - Machine learning COIS- Declarations. Ethics approval and consent to participate: Not Applicable. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/29 06:28 MHDA- 2025/11/29 06:29 PMCR- 2025/11/28 CRDT- 2025/11/29 00:58 PHST- 2025/02/28 00:00 [received] PHST- 2025/10/31 00:00 [accepted] PHST- 2025/11/29 06:29 [medline] PHST- 2025/11/29 06:28 [pubmed] PHST- 2025/11/29 00:58 [entrez] PHST- 2025/11/28 00:00 [pmc-release] AID - 10.1186/s40795-025-01208-w [pii] AID - 1208 [pii] AID - 10.1186/s40795-025-01208-w [doi] PST - epublish SO - BMC Nutr. 2025 Nov 28;12(1):1. doi: 10.1186/s40795-025-01208-w. PMID- 41316363 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251129 LR - 20251201 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 13 IP - 1 DP - 2025 Nov 28 TI - Examining the association among eating disorders and borderline personality disorder: evidence from youth in Saudi Arabia. PG - 276 LID - 10.1186/s40337-025-01455-z [doi] LID - 276 AB - BACKGROUND: Borderline Personality Disorder (BPD) is a complex psychiatric condition manifest by persistent instability in emotions, relationships, self-perception, and behavior. Eating disorders (EDs) are multifaceted neuropsychiatric conditions involving dysfunctional eating behaviors and psychological impairments, leading to adverse health outcomes and reduced quality of life. They are also associated with some of the highest mortality rates in psychiatry. EDs are typically classified to three main types: anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). Personality disorders are reflected as potential risk factors in the development of EDs. This study aimed to investigate the association between EDs and BPD among youth in Saudi Arabia. METHODS: A total of 433 participants aged 18-34 were included in this study. The research employed a quantitative, cross-sectional design, conducted between September and November 2024. Data were collected via an online questionnaire comprising three sections: demographic and health-related information, the McLean Screening Instrument (MSI-BPD) for BPD, and the Eating Disorder Questionnaire-Online (EDQ-O) for EDs. The design aimed to validate self-reported BPD symptoms and explore their association with EDs. RESULTS: The majority of the participants were female and educated Saudi persons who had no chronic illnesses; a notable 22.2% reported a formal diagnosis of BPD. The prevalence of EDs among the participants was found to be 67.9%. The findings revealed that BED was the most prevalent EDs among participants (45.03%), followed by BN at 22.17%, while AN was the least common (0.69%), indicating a higher occurrence of BED in the studied population. MSI-BPD screening results showed that 150 participants (34.64%) tested positive for BPD, with a higher prevalence among females (37.17%) compared to males (18.64%). A notably higher prevalence of EDs, particularly BED (74.67%) and BN (42.67%), was observed among participants with BPD, while AN remained rare in both groups. Pearson correlation analysis revealed statistically significant correlations (p < 0.01) between BPD and each EDs subtype (AN, BN, and BED), and the overall EDs symptom score. CONCLUSION: This study indicates a notable comorbidity between BPD and EDs, particularly BED and BN, reinforcing the strong tendency of these disorders to co-occur. CI - (c) 2025. The Author(s). FAU - Mansoury, Manal M S AU - Mansoury MMS AUID- ORCID: 0000-0003-0784-1825 AD - Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah, Saudi Arabia. mmmansouri@kau.edu.sa. FAU - Alsufyani, Shuruq A AU - Alsufyani SA AD - Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Alghamdi, Fatemah S AU - Alghamdi FS AUID- ORCID: 0000-0003-0452-9297 AD - Department of Psychology, Faculty of Art and Humanities, King Abdulaziz University, Jeddah, Saudi Arabia. LA - eng PT - Journal Article DEP - 20251128 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC12664173 OAB - This study examined the association between borderline personality disorder (BPD) and eating disorders (EDs) in youth in Saudi Arabia. BPD is a mental health condition that can lead to emotional dysregulation, unstable relationships, and identity disturbance. Eating disorders, such as AN, BN, and BED, can have a big effect on both mental and physical health. The study surveyed 433 people aged 18 to 34 about their mental health and eating habits. Approximately one-third of them showed signs of BPD, and more than two-thirds had symptoms of an EDs. BED was the most common type, especially in people with BPD. Women were more likely than men to have both BPD and EDs. This suggests that BPD and EDs often happen together, especially BED and BN. These results show how important it is to offer mental health care that addresses both emotional issues. OABL- eng OTO - NOTNLM OT - Borderline personality disorder OT - Eating disorders OT - Saudi arabia OT - Youth COIS- Declarations. Ethical approval and consent to participate: This study received ethical clearance from the Faculty of Arts and Humanities at King Abdulaziz University, Jeddah (Approval No. 4513481). Participants were fully informed about the study's purpose prior to completing the questionnaire and were given the freedom to participate voluntarily or decline. All data were handled with strict confidentiality, and participant identities remained anonymous. Competing interests: The authors declare no competing interests. EDAT- 2025/11/29 06:29 MHDA- 2025/11/29 06:30 PMCR- 2025/11/28 CRDT- 2025/11/29 00:56 PHST- 2025/08/03 00:00 [received] PHST- 2025/10/30 00:00 [accepted] PHST- 2025/11/29 06:30 [medline] PHST- 2025/11/29 06:29 [pubmed] PHST- 2025/11/29 00:56 [entrez] PHST- 2025/11/28 00:00 [pmc-release] AID - 10.1186/s40337-025-01455-z [pii] AID - 1455 [pii] AID - 10.1186/s40337-025-01455-z [doi] PST - epublish SO - J Eat Disord. 2025 Nov 28;13(1):276. doi: 10.1186/s40337-025-01455-z. PMID- 41316144 OWN - NLM STAT- MEDLINE DCOM- 20260113 LR - 20260115 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2025 Nov 28 TI - Fostering affect-related competencies and positive affective exercise experiences for promoting a physically active lifestyle in inactive young adults: study protocol for the FEEL cluster randomized controlled trial. PG - 137 LID - 10.1186/s12889-025-24374-9 [doi] LID - 137 AB - BACKGROUND: Growing evidence highlights the role of affective responses in shaping exercise behavior. Various factors, such as social setting, intensity, or activity type, influence affective exercise experiences. However, previous interventions have typically targeted only one factor at a time. The idea of the FEEL exercise program is to address these various factors in a holistic manner. Additionally, it focuses on fostering Physical Activity-Related Affect Regulation (PAAR) competence in participants, which is crucial for maintaining regular exercise behavior and well-being. METHODS: The FEEL study is a multicenter, cluster-randomized controlled trial. It evaluates the FEEL exercise program's efficacy compared to an active control group participating in a standardized Functional Training program. A total of 160 young adults (aged 18-35) who are not regularly exercising will be recruited across the two cities, Tubingen (Germany) and Bern (Switzerland). Both exercise programs consist of eight weekly 90-min group-based sessions. Primary outcome will assess PAAR using a validated scale, while secondary outcomes will include affective exercise experiences (AFFEXX), motivational competence, physical activity levels, and affective well-being. Measurements will be collected at baseline (t1), post-intervention (t2), and at an 8-week follow-up (t3). Data will be analyzed using multilevel modeling to examine group-by-time interactions, following a modified intention-to-treat approach. CONCLUSIONS: This study explores the impact of a holistic intervention in a primary and secondary prevention context. It may provide valuable insights for practical considerations of affective processes and related competencies in exercise programs. TRIAL REGISTRATION (RETROSPECTIVELY ON THE 31.10.2024): German Clinical Trials Register; ID: DRKS00035302. CI - (c) 2025. The Author(s). FAU - Buhrer, Martin AU - Buhrer M AD - Institute of Sport Science, University of Bern, Bremgartenstrasse 145, Bern, CH, 3012, Switzerland. martin.buehrer@unibe.ch. FAU - Rosenstiel, Stephanie AU - Rosenstiel S AD - Institute of Sports Science & Methods Center, Eberhard Karls University of Tubingen, Tubingen, Germany. FAU - Besel, Hannah AU - Besel H AD - Institute of Sports Science & Methods Center, Eberhard Karls University of Tubingen, Tubingen, Germany. FAU - Leyhr, Daniel AU - Leyhr D AD - Institute of Sports Science & Methods Center, Eberhard Karls University of Tubingen, Tubingen, Germany. FAU - Sudeck, Gorden AU - Sudeck G AD - Institute of Sports Science & Methods Center, Eberhard Karls University of Tubingen, Tubingen, Germany. AD - Interfaculty Research Institute for Sport and Physical Activity, Eberhard Karls University of Tubingen, Tubingen, Germany. FAU - Schmid, Julia AU - Schmid J AD - Institute of Sport Science, University of Bern, Bremgartenstrasse 145, Bern, CH, 3012, Switzerland. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20251128 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - *Exercise/psychology MH - Young Adult MH - Adult MH - Adolescent MH - Female MH - Male MH - *Affect MH - *Health Promotion/methods MH - Germany MH - Randomized Controlled Trials as Topic MH - *Sedentary Behavior MH - Multicenter Studies as Topic PMC - PMC12797374 OTO - NOTNLM OT - Body-inclusive spaces OT - Exercise Adherence OT - Experiential learning OT - Health literacy OT - Motivation OT - Physical literacy OT - Pleasure OT - Well-being COIS- Declarations. Ethics approval and consent to participate: The study is conducted according to the Declaration of Helsinki of 2010 guidelines. The study received approval from the Ethics Committee of the Faculty of Economics and Social Sciences at the University of Tubingen, Germany (ID: A2.5.4-334.1_hb) and the Ethics Commission of the Faculty of Human Sciences at the University of Bern, Switzerland (ID: 2024-02-06). Written informed consent is obtained from all participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/29 06:28 MHDA- 2026/01/13 07:42 PMCR- 2025/11/28 CRDT- 2025/11/29 00:47 PHST- 2025/03/14 00:00 [received] PHST- 2025/08/08 00:00 [accepted] PHST- 2026/01/13 07:42 [medline] PHST- 2025/11/29 06:28 [pubmed] PHST- 2025/11/29 00:47 [entrez] PHST- 2025/11/28 00:00 [pmc-release] AID - 10.1186/s12889-025-24374-9 [pii] AID - 24374 [pii] AID - 10.1186/s12889-025-24374-9 [doi] PST - epublish SO - BMC Public Health. 2025 Nov 28;26(1):137. doi: 10.1186/s12889-025-24374-9. PMID- 41316137 OWN - NLM STAT- MEDLINE DCOM- 20251129 LR - 20251202 IS - 1471-2482 (Electronic) IS - 1471-2482 (Linking) VI - 25 IP - 1 DP - 2025 Nov 28 TI - Combined laser ablation and pit excision for pilonidal sinus: effectiveness, quality of recovery, and patient-reported outcomes. PG - 576 LID - 10.1186/s12893-025-03319-4 [doi] LID - 576 AB - BACKGROUND: This retrospective study aimed to evaluate the efficacy, safety, and patient-reported long-term results of a minimally invasive method of diode laser ablation combined with pit excision for pilonidal sinus disease, reveal predictive factors affecting treatment success, and quantitatively examine patient satisfaction and quality of life dimensions. METHODS: Fifty-four adults were treated consecutively, and the primary analysis included 39 patients who 6month patientreported outcomes (PROs: QoR15, SAPS, PROMIS Global10) assessed by an independent investigator. The primary endpoints were recurrence and treatment success (no recurrence without re-intervention). Delayed healing was a composite of epithelialization > 30 days or discharge > 14 days. Exploratory subgroup analyses (sex and BMI) reported effect sizes with Benjamini-Hochberg-adjusted qvalues. Receiver operating characteristic (ROC) curve analysis assessed PRO discrimination for recurrence with 95% confidence intervals (CIs). RESULTS: Mean followup was 13.6 +/- 3.6 months; treatment success 84.6% (33/39), recurrence 15.4% (6/39), and delayed healing 20.5% (8/39). Mean PROs were: QoR15 136.8 +/- 19.9, SAPS 30.4 +/- 4.3, PROMIS 46.2 +/- 6.8; early postoperative pain (VAS) 1.9 +/- 1.3. QoR15, SAPS, and PROMIS correlated inversely with recurrence (r = - 0.46 to - 0.36; all p < 0.05) and showed AUCs of 0.79 (95% CI 0.65-0.93), 0.73 (0.58-0.88), and 0.70 (0.54-0.86), respectively. Age was associated with a longer recovery time (p = 0.002). No material differences in PROs by sex or BMI were observed after multiplicity control. CONCLUSIONS: In this single-center consecutive cohort, combined diode laser ablation with a pit excision technique was associated with short perioperative timelines, high patient-reported recovery/satisfaction, and acceptable mid-term recurrence, whereas PRO scores demonstrated fair discrimination for recurrence. Findings should be interpreted cautiously given the retrospective design and modest sample size; prospective, adequately powered studies are needed to validate the prognostic performance and comparative effectiveness. CI - (c) 2025. The Author(s). FAU - Canturk, Alp Omer AU - Canturk AO AUID- ORCID: 0000-0003-3641-7628 AD - Department of General Surgery, Sakarya Training and Research Hospital, Sakarya, Turkey. dr.omercanturk@gmail.com. FAU - Dikicier, Enis AU - Dikicier E AUID- ORCID: 0000-0002-5074-0299 AD - Faculty of Medicine, Department of General Surgery, Sakarya University, Sakarya, Turkey. FAU - Eroz, Erhan AU - Eroz E AUID- ORCID: 0000-0003-1044-1013 AD - Department of General Surgery, Sakarya Training and Research Hospital, Sakarya, Turkey. FAU - Aka, Bahaeddin Umur AU - Aka BU AUID- ORCID: 0000-0002-5757-1846 AD - Department of General Surgery, Sakarya Training and Research Hospital, Sakarya, Turkey. FAU - Tutar, Elif AU - Tutar E AUID- ORCID: 0009-0008-8984-0597 AD - Department of General Surgery, Sakarya Training and Research Hospital, Sakarya, Turkey. FAU - Soydas, Umit AU - Soydas U AUID- ORCID: 0009-0001-2877-6180 AD - Department of General Surgery, Sakarya Training and Research Hospital, Sakarya, Turkey. FAU - Altintoprak, Fatih AU - Altintoprak F AUID- ORCID: 0000-0002-3939-8293 AD - Faculty of Medicine, Department of General Surgery, Sakarya University, Sakarya, Turkey. LA - eng PT - Journal Article DEP - 20251128 PL - England TA - BMC Surg JT - BMC surgery JID - 100968567 SB - IM MH - Humans MH - *Pilonidal Sinus/surgery MH - Male MH - Female MH - Adult MH - *Patient Reported Outcome Measures MH - Retrospective Studies MH - *Laser Therapy/methods MH - Treatment Outcome MH - Young Adult MH - Patient Satisfaction MH - Quality of Life MH - Recurrence MH - *Lasers, Semiconductor/therapeutic use MH - Middle Aged MH - Combined Modality Therapy MH - Adolescent MH - Follow-Up Studies PMC - PMC12661896 OTO - NOTNLM OT - Diode laser ablation OT - Minimally invasive surgery OT - Patient satisfaction OT - Patient-Reported outcomes measurement information system (PROMIS) OT - Pilonidal sinus disease OT - Pit excision OT - Quality of recovery-15 (QoR-15) OT - Recurrence prediction OT - Short assessment of patient satisfaction (SAPS) COIS- Declarations. Ethics approval and consent to participate: This non-interventional retrospective study was approved by the Non-Interventional Ethics Committee of the Faculty of Medicine, Sakarya University (Approval No. E-71522473-050.04 -364065) The requirement for written informed consent was waived by the committee due to the study's retrospective design. Consent for publication: Not applicable. This manuscript does not contain any individual person's data (including videos, or identifying details). Competing interests: The authors declare no competing interests. EDAT- 2025/11/29 06:28 MHDA- 2025/11/29 06:29 PMCR- 2025/11/28 CRDT- 2025/11/29 00:46 PHST- 2025/07/18 00:00 [received] PHST- 2025/10/27 00:00 [accepted] PHST- 2025/11/29 06:29 [medline] PHST- 2025/11/29 06:28 [pubmed] PHST- 2025/11/29 00:46 [entrez] PHST- 2025/11/28 00:00 [pmc-release] AID - 10.1186/s12893-025-03319-4 [pii] AID - 3319 [pii] AID - 10.1186/s12893-025-03319-4 [doi] PST - epublish SO - BMC Surg. 2025 Nov 28;25(1):576. doi: 10.1186/s12893-025-03319-4. PMID- 41316041 OWN - NLM STAT- MEDLINE DCOM- 20251230 LR - 20260625 IS - 1471-2342 (Electronic) IS - 1471-2342 (Linking) VI - 25 IP - 1 DP - 2025 Nov 28 TI - CT-assessed pectoralis major muscle measurements as risk factors for low neoadjuvant chemotherapy efficacy in osteosarcoma: a retrospective study. PG - 530 LID - 10.1186/s12880-025-02087-0 [doi] LID - 530 AB - BACKGROUND: Neoadjuvant chemotherapy (NAC) response in terms of tumor necrosis for osteosarcoma is of clinical significance for subsequent treatment, CT-acquired parameters indicating sarcopenia were reported to be the risk factors of low NAC efficacy in a variety of malignant tumors, yet the association between chest CT-derived pectoralis major muscle measurements and tumor necrosis of osteosarcoma have not been revealed. METHODS: The pectoralis major muscle area, normalized pectoralis major muscle index (PMI) and CT attenuation acquired from preoperative chest CT as well as clinical data of 131 osteosarcoma patients were retrospectively analyzed and compared between favorable NAC response (tumor necrosis >/= 90%) and poor NAC response group (tumor necrosis < 90%). For the evaluation of interobserver reproducibility, interclass correlation coefficient (ICC) with 95% confidence interval (CI) was used. The receiver operating characteristic (ROC) analysis was performed to determine the efficiency of each measurement and to calculate the optimal cut-off values of significant parameters. Multivariable binary logistic regression analysis was performed to determine the risk factors of low NAC efficacy. RESULTS: A total of 79 lesions from 78 patients were eligible for this study (mean age, 17.6 +/- 0.9 years; 45 male), 34 lesions constituted the favorable response (FR) group and 45 lesions constituted the poor response (PR) group. Pectoralis major muscle measurements were significantly higher in FR group than in PR group (muscle area, 11.56 +/- 4.48 VS 9.42 +/- 3.57, P = 0.021; PMI, 7.32 +/- 2.23 VS 5.64 +/- 1.54, P < 0.001; CT attenuation, 38.78 +/- 8.44 VS 31.96 +/- 11.37, P = 0.004). Excellent interobserver agreement was found in these parameters with ICC values ranging 0.925-0.944. In ROC analysis, PMI showed an area under curve (AUC) of 0.727, 95% CI: 0.612, 0.842, the threshold value for differentiating FR from PR was 7.147. PMI were risk factors of low NAC efficacy with the P value of 0.007. CONCLUSIONS: Chest CT-accessed pectoralis major muscle area, PMI and CT attenuation were significantly correlated with tumor necrosis in osteosarcoma, these can be potentially helpful imaging auxiliary biomarkers for predicting NAC response of osteosarcoma. CI - (c) 2025. The Author(s). FAU - Li, Zhijun AU - Li Z AD - Department of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - Tianjin's Clinical Research Center for Cancer, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - Key Laboratory of Cancer Prevention and Therapy, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. FAU - Zhang, Yaodan AU - Zhang Y AD - Department of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - Tianjin's Clinical Research Center for Cancer, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - Key Laboratory of Cancer Prevention and Therapy, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. FAU - Wu, Haixiao AU - Wu H AD - Tianjin's Clinical Research Center for Cancer, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - Key Laboratory of Cancer Prevention and Therapy, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - Department of Bone and Soft Tissue Tumors, Cancer Institute & Hospital, Tianjin Medical University, National Clinical Research Center for Cancer, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. FAU - Zhang, Chao AU - Zhang C AD - Tianjin's Clinical Research Center for Cancer, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - Key Laboratory of Cancer Prevention and Therapy, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - Department of Bone and Soft Tissue Tumors, Cancer Institute & Hospital, Tianjin Medical University, National Clinical Research Center for Cancer, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. FAU - Ye, Zhaoxiang AU - Ye Z AD - Department of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. yezhaoxiang@163.com. AD - Tianjin's Clinical Research Center for Cancer, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. yezhaoxiang@163.com. AD - State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. yezhaoxiang@163.com. AD - Key Laboratory of Cancer Prevention and Therapy, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. yezhaoxiang@163.com. LA - eng GR - TJYXZDXK-009A/Tianjin Key Medical Discipline (Specialty) Construction Project/ GR - 2021YFC2500400/The Chinese National Key Research and Development Project/ PT - Journal Article DEP - 20251128 PL - England TA - BMC Med Imaging JT - BMC medical imaging JID - 100968553 SB - IM MH - Humans MH - Male MH - *Osteosarcoma/drug therapy/diagnostic imaging/pathology MH - Female MH - Retrospective Studies MH - *Pectoralis Muscles/diagnostic imaging/pathology MH - *Neoadjuvant Therapy MH - Risk Factors MH - *Tomography, X-Ray Computed/methods MH - Adolescent MH - *Bone Neoplasms/drug therapy/diagnostic imaging/pathology MH - Young Adult MH - Child MH - Sarcopenia/diagnostic imaging MH - ROC Curve MH - Adult PMC - PMC12751793 OTO - NOTNLM OT - Body composition OT - Computed tomography OT - Neoadjuvant chemotherapy OT - Osteosarcoma OT - Sarcopenia COIS- Declarations. Ethics approval and consent to participate: The present study was in accordance with the Declaration of Helsinki. This retrospective study was approved by the institutional review board of Tianjin Medical University and the requirement to obtain informed consent was waived (clinical trial: bc2021011). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/29 06:28 MHDA- 2025/12/31 06:13 PMCR- 2025/11/28 CRDT- 2025/11/29 00:43 PHST- 2024/09/08 00:00 [received] PHST- 2025/11/24 00:00 [accepted] PHST- 2025/12/31 06:13 [medline] PHST- 2025/11/29 06:28 [pubmed] PHST- 2025/11/29 00:43 [entrez] PHST- 2025/11/28 00:00 [pmc-release] AID - 10.1186/s12880-025-02087-0 [pii] AID - 2087 [pii] AID - 10.1186/s12880-025-02087-0 [doi] PST - epublish SO - BMC Med Imaging. 2025 Nov 28;25(1):530. doi: 10.1186/s12880-025-02087-0. PMID- 41314834 OWN - NLM STAT- MEDLINE DCOM- 20251128 LR - 20251203 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 11 DP - 2025 Nov 28 TI - Is Cardiovascular Mortality Among People with Epilepsy increasing? A retrospective US population study. PG - e095195 LID - 10.1136/bmjopen-2024-095195 [doi] LID - e095195 AB - INTRODUCTION: People with epilepsy are at higher risk for hypertension, diabetes, hyperlipidaemia and obesity than the US general population. It is unknown whether these risk factors translate to increased cardiovascular mortality compared with the US general population. OBJECTIVE: To examine changes in the proportions of deaths due to cardiovascular causes among people with epilepsy in the USA. HYPOTHESIS: Cardiovascular mortality among people with epilepsy is rising in the USA compared with the general population over the period from 2000 to 2019. DESIGN/METHODS: Retrospective, longitudinal US population study of all deaths among people with epilepsy due to cardiovascular causes compared with the US general population for the years 2000 through 2019. Source data were obtained from the Centers for Disease Control and Prevention (CDC) Multiple Cause of Death Database using all International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10) codes for epilepsy (specifically all ICD-10 codes G40.0 through G40.919). The use of administrative datasets, like the CDC Multiple Cause Of Death Database, is a validated method that effectively captures US epilepsy mortality when using the ICD-10 codes G40.0-G40.9. Cardiovascular deaths were operationally defined as ischaemic heart disease, cerebrovascular disease, diabetes and hypertension. Data were stratified by age, race and gender. Relative proportions of each cause of death were expressed as a percentage of total deaths and evaluated on the log-odds scale using a logistic regression model. Standardised proportions were also used and reported. PRIMARY AND SECONDARY OUTCOMES: Within-group and between-group differences in the rate/proportions of deaths due to cerebrovascular disease, ischaemic heart disease, diabetes and hypertension among people with epilepsy and the general population over a 20-year period. SETTING: US epilepsy and general populations. RESULTS: Age-adjusted mortality for cerebrovascular disease and diabetes increased significantly among people with epilepsy compared with the US general population over the 20-year period (p<0.001). Age-stratified comparisons indicate that the proportions of deaths due to cerebrovascular disease and diabetes increased significantly among people with epilepsy compared with the general population aged 35-64 years. An unexpected finding is a trend reversal in the proportions of deaths from ischaemic heart disease among people with epilepsy. Prior to 2011, the proportion of deaths due to ischaemic heart disease among people with epilepsy declined steadily at a slope of -0.265 annually. After 2011, the slope changed from -0.265 to virtually zero in contrast to the continued decline in the US general population (epilepsy vs general population slope difference: p<0.001 after the breakpoint year). CONCLUSIONS: Age-standardised proportions of deaths attributed to cerebrovascular disease and diabetes increased significantly among people with epilepsy from 2000 to 2019. Age-stratified proportions of deaths due to cerebrovascular disease and diabetes occurred primarily in the 35-64-year age range. The long decline in the proportions of deaths due to ischaemic heart disease among people with epilepsy ended after 2011, despite continuing to decline in the general population. The increase in proportions of cardiovascular deaths among people with epilepsy is likely due to higher cardiovascular risk factors compared with the general US population. Increased surveillance and treatment of cardiovascular risk factors among people with epilepsy are indicated, especially in the critical 35-64-year age group, where improved primary prevention may reduce cardiovascular risk and mortality. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Curtis, Ashley AU - Curtis A AD - California University of Science and Medicine, Colton, California, USA. FAU - Markovic, Daniela AU - Markovic D AD - UCLA, Los Angeles, California, USA. FAU - Liao, Andrew AU - Liao A AD - California University of Science and Medicine, Colton, California, USA. FAU - Ganapa, Somnath AU - Ganapa S AD - Medicine, UCLA, Los Angeles, California, USA. FAU - Gaertner, Mark AU - Gaertner M AD - Neurology, UCLA, Los Angeles, California, USA. FAU - DeGiorgio, Christopher M AU - DeGiorgio CM AUID- ORCID: 0000-0002-9863-9069 AD - Neurology, UCLA, Los Angeles, California, USA cmd@mednet.ucla.edu. LA - eng PT - Journal Article DEP - 20251128 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Epilepsy/complications/mortality/epidemiology MH - Female MH - Retrospective Studies MH - Male MH - United States/epidemiology MH - *Cardiovascular Diseases/mortality MH - Middle Aged MH - Adult MH - Aged MH - Longitudinal Studies MH - Cause of Death/trends MH - Young Adult MH - Hypertension/mortality MH - Risk Factors MH - Adolescent PMC - PMC12666228 OTO - NOTNLM OT - Cardiovascular Disease OT - Epilepsy OT - Hypertension OT - Mortality OT - Risk Factors OT - Stroke COIS- Competing interests: None declared. EDAT- 2025/11/29 02:21 MHDA- 2025/11/29 02:22 PMCR- 2025/11/28 CRDT- 2025/11/28 21:43 PHST- 2025/11/29 02:22 [medline] PHST- 2025/11/29 02:21 [pubmed] PHST- 2025/11/28 21:43 [entrez] PHST- 2025/11/28 00:00 [pmc-release] AID - bmjopen-2024-095195 [pii] AID - 10.1136/bmjopen-2024-095195 [doi] PST - epublish SO - BMJ Open. 2025 Nov 28;15(11):e095195. doi: 10.1136/bmjopen-2024-095195. PMID- 41314793 OWN - NLM STAT- MEDLINE DCOM- 20260313 LR - 20260313 IS - 1468-330X (Electronic) IS - 0022-3050 (Linking) VI - 97 IP - 4 DP - 2026 Mar 13 TI - Vitamin D intake and multiple sclerosis risk in the Norwegian Mother, Father and Child cohort. PG - 309-315 LID - 10.1136/jnnp-2025-337300 [doi] AB - BACKGROUND: Higher vitamin D has consistently been associated with a lower multiple sclerosis (MS) risk, but some controversy remains about whether this is due to vitamin D itself or sunlight. METHODS: We conducted a prospective study among women participating in the Norwegian Mother, Father and Child Cohort Study, recruited in 2002-2008 and followed until 2022. We identified incident MS cases through data linkage with the Norwegian MS Registry. Total vitamin D intake from food and supplements was obtained from validated food frequency questionnaires completed in pregnancy. We estimated HRs for MS and 95% confidence intervals (CI) using Cox regression. RESULTS: Among 78 074 participants, 349 developed MS during follow-up. Their median daily vitamin D intake was 296 international units (IU) compared with 333 IU among women who did not develop MS. Higher total vitamin D intake was associated with a 42% lower MS risk (HR comparing top vs bottom quintile 0.58, 95% CI 0.38 to 0.89, p(trend)<0.01). The results were similar when adjusting for age at delivery, total energy intake, pre-pregnancy body mass index and smoking. The associations were similar for vitamin D intake from food (HR for top vs bottom quintile 0.70, 95% CI 0.47 to 0.1.04, p(trend)=0.02) and supplements (HR for >/=600 IU/day vs <200 IU/day 0.65, 95% CI 0.41 to 1.04, p(trend)=0.01). CONCLUSIONS: In this prospective study, higher vitamin D intake was associated with lower MS risk in women living in Norway, where there is insufficient sun-induced vitamin D production during most of the year. This supports the hypothesis that vitamin D itself modifies MS risk. CI - (c) Author(s) (or their employer(s)) 2026. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Kapali, Akash AU - Kapali A AUID- ORCID: 0000-0002-0581-4981 AD - Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. AD - Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, Norway. FAU - Daltveit, Anne Kjersti AU - Daltveit AK AD - Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. AD - Department of Health Registry Research and Development, Norwegian Institute of Public Health, Bergen, Norway. FAU - Myhr, Kjell-Morten AU - Myhr KM AD - Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, Norway. AD - Department of Clinical Medicine, University of Bergen, Bergen, Norway. FAU - Bjornevik, Kjetil AU - Bjornevik K AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. AD - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. FAU - Eid, Karine AU - Eid K AUID- ORCID: 0000-0002-5158-7636 AD - Department of Clinical Medicine, University of Bergen, Bergen, Norway. AD - Department of Neurology, Haukeland University Hospital, Bergen, Norway. FAU - Bjork, Marte-Helene AU - Bjork MH AD - Department of Clinical Medicine, University of Bergen, Bergen, Norway. AD - Department of Neurology, Haukeland University Hospital, Bergen, Norway. FAU - Brantsaeter, Anne Lise AU - Brantsaeter AL AUID- ORCID: 0000-0001-6315-7134 AD - Department of Food Safety, Norwegian Institute of Public Health, Oslo, Norway. AD - Centre for Sustainable Diets, Norwegian Institute of Public Health, Oslo, Norway. FAU - Riise, Trond AU - Riise T AUID- ORCID: 0000-0001-9644-5140 AD - Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. AD - Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, Norway. FAU - Cortese, Marianna AU - Cortese M AUID- ORCID: 0000-0002-3665-2006 AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA marianna.cortese@uib.no. LA - eng PT - Journal Article DEP - 20260313 PL - England TA - J Neurol Neurosurg Psychiatry JT - Journal of neurology, neurosurgery, and psychiatry JID - 2985191R RN - 1406-16-2 (Vitamin D) SB - IM MH - Humans MH - *Multiple Sclerosis/epidemiology MH - *Vitamin D/administration & dosage MH - Female MH - Norway/epidemiology MH - Adult MH - Prospective Studies MH - Male MH - Dietary Supplements MH - Risk Factors MH - Pregnancy MH - Middle Aged MH - Cohort Studies MH - Mothers MH - Fathers OTO - NOTNLM OT - EPIDEMIOLOGY OT - MULTIPLE SCLEROSIS COIS- Competing interests: AK, AKD, K-MM, KB, KE, ALB, TR and MC report no competing interests. M-HB reported institutional payment from the Marked authorisation holders of valproate (Sanofi, Desitin and more) for the conduction of a post-authorisation safety study and lecture honouraria from Eisai, AbbVie, Angelini Pharma, Novartis, Pfizer, BestPractice and Organon and advisory board honouraria from Jazz Pharmaceuticals, Angelini Pharma, Lundbeck, Pfizer and Eisai, none related to the present topic. EDAT- 2025/11/29 02:21 MHDA- 2026/03/14 00:31 CRDT- 2025/11/28 21:23 PHST- 2025/08/04 00:00 [received] PHST- 2025/11/04 00:00 [accepted] PHST- 2026/03/14 00:31 [medline] PHST- 2025/11/29 02:21 [pubmed] PHST- 2025/11/28 21:23 [entrez] AID - jnnp-2025-337300 [pii] AID - 10.1136/jnnp-2025-337300 [doi] PST - epublish SO - J Neurol Neurosurg Psychiatry. 2026 Mar 13;97(4):309-315. doi: 10.1136/jnnp-2025-337300. PMID- 41314055 OWN - NLM STAT- MEDLINE DCOM- 20260109 LR - 20260814 IS - 1879-0046 (Electronic) IS - 0376-8716 (Print) IS - 0376-8716 (Linking) VI - 278 DP - 2026 Jan 1 TI - Optimizing measures of drinking to predict alcohol-related consequences. PG - 112973 LID - S0376-8716(25)00426-0 [pii] LID - 10.1016/j.drugalcdep.2025.112973 [doi] AB - BACKGROUND: Alcohol use surges in late adolescence, particularly among college students, and is associated with a wide variety of negative socio-emotional, academic, legal, and health consequences. Although most studies assess risk for these consequences through self-report of drinking quantity and frequency, ample evidence indicates that youth who drink alcohol can be inaccurate in reporting their drinking behavior and that estimates become increasingly biased as drinking increases. In the current study, we examined two approaches for optimizing self-reported alcohol consumption estimates to assess associations with drinking consequences. BASIC PROCEDURE: The primary sample included 572 college students (53.9 % female; 18-23 age; 61.4 % White, 20.5 % Black, and 18.1 % additional racial-ethnic groups) who completed surveys and a standard lab-based free-pour knowledge task. We tested associations between consumption and consequences (as moderated by body mass index) using both multiple regression with covariates and instrumental variable analyses. MAIN FINDINGS: Indicators of inaccuracy in self-reported consumption met requirements for serving as instrumental variables. In all models, consumption and consequences were strongly associated, though predictive validity measures differed in which technique they favored. Consumption rates only predicted consequences when body mass index was less than ~34 (obesity class 1). CONCLUSIONS: Our results demonstrate that including assessments of reporting inaccuracy, alcohol knowledge, and body mass index when studying alcohol consumption may be important for reducing bias due to measurement error and predicting consequences of alcohol use. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Hussong, Andrea M AU - Hussong AM AD - University of North Carolina at Chapel Hill, CB#3270 Davie Hall, UNC-CH, Chapel Hill, NC 27599-3270, USA. Electronic address: hussong@unc.edu. FAU - Traver, Jennifer M AU - Traver JM AD - University of North Carolina at Chapel Hill, CB#3270 Davie Hall, UNC-CH, Chapel Hill, NC 27599-3270, USA. Electronic address: jmtraver@unc.edu. LA - eng GR - R01 DA034636/DA/NIDA NIH HHS/United States PT - Journal Article DEP - 20251120 PL - Ireland TA - Drug Alcohol Depend JT - Drug and alcohol dependence JID - 7513587 SB - IM MH - Humans MH - Female MH - Male MH - Adolescent MH - Young Adult MH - *Alcohol Drinking/psychology/epidemiology/adverse effects MH - *Self Report/standards MH - Students/psychology MH - *Alcohol Drinking in College/psychology MH - Body Mass Index MH - Universities PMC - PMC12677144 MID - NIHMS2126062 OTO - NOTNLM OT - Alcohol OT - Alcohol Consumption OT - Alcohol consequences OT - Bias OT - Measurement COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/11/29 02:21 MHDA- 2026/01/10 00:34 PMCR- 2026/11/20 CRDT- 2025/11/28 18:08 PHST- 2025/03/03 00:00 [received] PHST- 2025/11/09 00:00 [revised] PHST- 2025/11/17 00:00 [accepted] PHST- 2026/01/10 00:34 [medline] PHST- 2025/11/29 02:21 [pubmed] PHST- 2025/11/28 18:08 [entrez] PHST- 2026/11/20 00:00 [pmc-release] AID - S0376-8716(25)00426-0 [pii] AID - 10.1016/j.drugalcdep.2025.112973 [doi] PST - ppublish SO - Drug Alcohol Depend. 2026 Jan 1;278:112973. doi: 10.1016/j.drugalcdep.2025.112973. Epub 2025 Nov 20. PMID- 41313348 OWN - NLM STAT- MEDLINE DCOM- 20261022 LR - 20261027 IS - 1432-1971 (Electronic) IS - 0172-0643 (Linking) VI - 47 IP - 8 DP - 2026 Dec TI - Physician Preparedness for Managing Juvenile Obesity in the MENA Region: A Cross-Sectional Analysis of Perceptions, Knowledge, Practices, and Barriers. PG - 3342-3353 LID - 10.1007/s00246-025-04121-y [doi] AB - This study aimed to evaluate physicians' preparedness to manage juvenile obesity (JO) in the Middle East and North Africa (MENA) region by assessing their attitudes, knowledge, clinical practices, confidence, and perceived barriers. A 38-question cross-sectional survey was created, validated, and distributed in December 2024 across MENA countries using a skip-logic-tailored, bilingual (Arabic/English) online platform. It assessed physicians' attitudes, familiarity with JO-management guidelines and concepts, screening and treatment practices, prior JO-training, confidence, and barriers. Data were analyzed using both descriptive and inferential statistics. The study included 400 physicians (54% female, 57% younger than 35, 65% primary care physicians). 90% considered JO a routine checkup priority. Two-thirds reported no JO-training; half were unfamiliar with JO-management guidelines, and 45-65% were unfamiliar with JO-management concepts. Screening was suboptimal, with 25% relying exclusively on visual assessment. Behavioral therapy (33%) and pharmacologic treatments (17%) were underutilized. Most (73%) reported low to moderate confidence in managing JO. Confidence was significantly associated with guideline awareness and recent JO-training. Guideline awareness was also associated with recent JO-training. Physicians aware of guidelines were more likely to applying evidence-based practices (p < 0.001). Majoy selected barriers included lack of JO-training, institutional limitations, and socio-cultural factors. Physicians in MENA face deficits in JO-training, JO-management guidelines awareness, and systemic support that limit confidence in JO management. Expanding JO-training, disseminating regionally-suitable guidelines, and enhancing institutional support are essential to improving physician preparedness for JO management. CI - (c) 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Daoud, Ala AU - Daoud A AD - Independent clinical pharmacist (AHPRA registered), Sydney, Australia. AD - , Riyadh, Saudi Arabia. FAU - Qunaibi, Eyad A AU - Qunaibi EA AD - MedOne Academy, Dover, DE, USA. FAU - Raies, Shahem AU - Raies S AD - Otorhinolaryngology Department, Hama National Hospital, Hama, Syria. AD - Al-Andalus University for Medical Sciences, Qadmus, Tartus, Syria. FAU - Altorman, Ula Y AU - Altorman UY AD - Prince Hamza Hospital, Amman, Jordan. AD - Jordan University of Science and Technology, Irbid, Jordan. FAU - Salim, Ahmed AU - Salim A AD - King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. FAU - Wali, Saad M AU - Wali SM AD - Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia. FAU - Al-Yafeai, Taliaa M AU - Al-Yafeai TM AD - Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah, United Arab Emirates. FAU - Alsaied, Tarek AU - Alsaied T AD - Division of Pediatric Cardiology, Children's Medical Center of Dallas, University of Texas Southwestern, Dallas, TX, USA. tarek.alsaied@utsouthwestern.edu. AD - Division of Pediatric Cardiology, UPMC, University of Pittsburgh, Pittsburgh, PA, USA. tarek.alsaied@utsouthwestern.edu. LA - eng PT - Journal Article DEP - 20251128 PL - United States TA - Pediatr Cardiol JT - Pediatric cardiology JID - 8003849 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Middle East MH - *Health Knowledge, Attitudes, Practice MH - Male MH - Africa, Northern MH - *Pediatric Obesity/therapy MH - Adult MH - *Practice Patterns, Physicians'/statistics & numerical data MH - *Attitude of Health Personnel MH - Child MH - Surveys and Questionnaires MH - *Clinical Competence OTO - NOTNLM OT - Barriers OT - Childhood obesity OT - Confidence OT - Guideline familiarity OT - Middle east and north africa OT - Pediatric obesity COIS- Declarations. Competing Interests: The authors declare no competing interests. Ethical Approval: Ethical approval was obtained from the Jordan Ministry of Health (No. 19338), Prince Hamzah Hospital (No. 13424), and King Abdullah University Hospital (No. 2024/176/10). The study involved no clinical interventions and was conducted in accordance with the Declaration of Helsinki and its amendments. Consent to Participate: Participation was voluntary, and electronic informed consent was obtained from all participants prior to the initiation of the survey. Participation was anonymous; IP addresses were used solely to detect duplicate entries and were not retained in the analytic dataset. Consent for Publication: Not applicable: the manuscript contains no personal information in any form (text, images, or recordings). Declaration of Generative AI and AI-Assisted Technologies in the Writing Process: During the preparation of this work, the authors utilized ChatGPT (OpenAI, GPT-4, GPT-4.5, and GPT-5) to enhance clarity and refine the language. After using this tool, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication. EDAT- 2025/11/28 13:30 MHDA- 2026/10/22 23:28 CRDT- 2025/11/28 11:02 PHST- 2025/09/13 00:00 [received] PHST- 2025/11/12 00:00 [accepted] PHST- 2026/10/22 23:28 [medline] PHST- 2025/11/28 13:30 [pubmed] PHST- 2025/11/28 11:02 [entrez] AID - 10.1007/s00246-025-04121-y [pii] AID - 10.1007/s00246-025-04121-y [doi] PST - ppublish SO - Pediatr Cardiol. 2026 Dec;47(8):3342-3353. doi: 10.1007/s00246-025-04121-y. Epub 2025 Nov 28. PMID- 41312254 OWN - NLM STAT- MEDLINE DCOM- 20251128 LR - 20251130 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Eating habits, nutritional status, and lifestyle correlates of body composition in Chinese university students: a cross-sectional study. PG - 1668307 LID - 10.3389/fpubh.2025.1668307 [doi] LID - 1668307 AB - BACKGROUND: Unhealthy eating habits and nutritional imbalances are prevalent among university students and may contribute to hidden obesity and metabolic risk. Understanding the dietary patterns and lifestyle factors associated with body composition is essential for designing effective interventions in this population. OBJECTIVE: This study aimed to assess the dietary habits, nutritional status, and lifestyle correlates of body composition among Chinese university students, with a focus on the prevalence of hidden obesity and low protein mass. METHODS: A cross-sectional survey was conducted among 993 undergraduate students at a major Chinese university. Dietary intake, physical activity, sleep, and other lifestyle factors were assessed using validated questionnaires. Body composition, including body fat percentage and protein status, was measured with a bioelectrical impedance analyzer. Associations between dietary/lifestyle factors and body composition were examined using multivariable regression analyses. RESULTS: Fewer than half of participants reported daily consumption of vegetables, and only 18.2% consumed fruit daily. Hidden obesity, defined as excessive body fat despite normal body mass index, was observed in 17.0% of students, significantly higher among females (23.0%) than males (1.1%) (p < 0.05). Low protein mass, as measured by bioelectrical impedance analysis, was present in 31.0% of students and was more prevalent among females (33.5%) than males (24.6%) (p < 0.05). Weekly fruit intake showed a weak but positive association with both body fat and protein percentages, after adjusting for confounders (p < 0.05). CONCLUSION: Unbalanced dietary patterns, hidden obesity, and low protein mass are widespread among Chinese university students, with sex-specific differences. The relationship between fruit intake and body composition may reflect broader dietary or lifestyle behaviors rather than a direct protective effect. CI - Copyright (c) 2025 Liu, Gong, Li, Zhou and Lin. FAU - Liu, Ling AU - Liu L AD - School of Clinical Medicine, Sichuan College of Traditional Chinese Medicine, Mianyang, Sichuan, China. FAU - Gong, Wan AU - Gong W AD - School of Clinical Medicine, Sichuan College of Traditional Chinese Medicine, Mianyang, Sichuan, China. FAU - Li, Jun AU - Li J AD - School of Clinical Medicine, Sichuan College of Traditional Chinese Medicine, Mianyang, Sichuan, China. FAU - Zhou, Wei AU - Zhou W AD - School of Clinical Medicine, Sichuan College of Traditional Chinese Medicine, Mianyang, Sichuan, China. FAU - Lin, Li AU - Lin L AD - Institute for Nutrition and Food Safety, Sichuan Center for Disease Control and Prevention, Chengdu, Sichuan, China. LA - eng PT - Journal Article PT - Review DEP - 20251112 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Male MH - Female MH - Cross-Sectional Studies MH - *Students/statistics & numerical data MH - *Nutritional Status MH - Universities MH - China/epidemiology MH - *Body Composition MH - *Feeding Behavior MH - *Life Style MH - Young Adult MH - Adult MH - Obesity/epidemiology MH - Surveys and Questionnaires MH - Adolescent PMC - PMC12646914 OTO - NOTNLM OT - dietary habits OT - fruit intake OT - hidden obesity OT - low protein mass OT - nutrition intervention COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/11/28 06:27 MHDA- 2025/11/28 06:28 PMCR- 2025/11/12 CRDT- 2025/11/28 04:47 PHST- 2025/07/17 00:00 [received] PHST- 2025/10/27 00:00 [accepted] PHST- 2025/11/28 06:28 [medline] PHST- 2025/11/28 06:27 [pubmed] PHST- 2025/11/28 04:47 [entrez] PHST- 2025/11/12 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1668307 [doi] PST - epublish SO - Front Public Health. 2025 Nov 12;13:1668307. doi: 10.3389/fpubh.2025.1668307. eCollection 2025. PMID- 41312230 OWN - NLM STAT- MEDLINE DCOM- 20251128 LR - 20251130 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Psychometric evaluation of the Adult Eating Behavior Questionnaire and its relationship with body mass index among Chinese university students: a cross-sectional validation study. PG - 1691302 LID - 10.3389/fpubh.2025.1691302 [doi] LID - 1691302 AB - BACKGROUND: Eating behavior critically impacts human health and the development of obesity. This study aimed to validate the Adult Eating Behavior Questionnaire (AEBQ) among Chinese university students and explore the relationship between appetitive traits and body mass index (BMI). METHODS: A total of 546 students from Southeast University completed the Chinese version of the AEBQ and self-reported anthropometric data. Confirmatory factor analysis (CFA) was used to test the factor structure and evaluate model fit, and Spearman's correlation assessed relationships between appetitive traits and BMI. RESULTS: The original 8-factor, 35-item model showed a good fit, which improved further after removing the Hunger subscale. All subscales demonstrated strong reliability (alpha and omega > 0.70). Females exhibited higher scores in Enjoyment of Food, Emotional Over-eating, Food Responsiveness, and Satiety Responsiveness than males (p < 0.05). Food approach traits (except for Hunger) were positively correlated with BMI (p < 0.05), whereas food avoidance traits (except for Food Fussiness) were negatively correlated (p < 0.05). CONCLUSION: The AEBQ is a reliable and valid psychological measurement for assessing appetitive traits in Chinese adults and conducting large-scale studies. Interventions targeting appetite traits provide new insights into weight management and obesity prevention. CI - Copyright (c) 2025 Yan, Shah, Yang, Pan and Sun. FAU - Yan, Qinyu AU - Yan Q AD - Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China. FAU - Shah, Muhammad Waseem AU - Shah MW AD - Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China. FAU - Yang, Jin AU - Yang J AD - Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China. FAU - Pan, Da AU - Pan D AD - Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China. FAU - Sun, Guiju AU - Sun G AD - Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20251112 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Female MH - Male MH - *Students/statistics & numerical data/psychology MH - *Body Mass Index MH - *Feeding Behavior/psychology MH - Universities MH - *Psychometrics MH - Cross-Sectional Studies MH - Surveys and Questionnaires/standards MH - China MH - Adult MH - Young Adult MH - Reproducibility of Results MH - Adolescent PMC - PMC12646881 OTO - NOTNLM OT - Chinese university students OT - adult eating behavior questionnaire OT - appetitive traits OT - body mass index OT - obesity COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/11/28 06:28 MHDA- 2025/11/28 06:29 PMCR- 2025/11/12 CRDT- 2025/11/28 04:47 PHST- 2025/08/23 00:00 [received] PHST- 2025/10/31 00:00 [accepted] PHST- 2025/11/28 06:29 [medline] PHST- 2025/11/28 06:28 [pubmed] PHST- 2025/11/28 04:47 [entrez] PHST- 2025/11/12 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1691302 [doi] PST - epublish SO - Front Public Health. 2025 Nov 12;13:1691302. doi: 10.3389/fpubh.2025.1691302. eCollection 2025. PMID- 41310816 OWN - NLM STAT- MEDLINE DCOM- 20251231 LR - 20260919 IS - 1757-2215 (Electronic) IS - 1757-2215 (Linking) VI - 18 IP - 1 DP - 2025 Nov 27 TI - A prospective cohort study on progestin-primed ovarian stimulation vs. GnRH antagonist in IVF-ICSI cycles: effects on clinical pregnancy and neonatal outcomes. PG - 313 LID - 10.1186/s13048-025-01885-y [doi] LID - 313 AB - BACKGROUND: In assisted reproductive technology, preventing premature ovulation is crucial for achieving successful pregnancy outcomes. The traditional GnRH antagonist protocol is commonly used to suppress the luteinizing hormone (LH) surge, while the progesterone-primed ovarian stimulation (PPOS) protocol has gained attention due to its simplicity, lower cost, and fewer side effects. This study compared the PPOS and GnRH antagonist protocols in frozen embryo transfer (FET) cycles, focusing on evaluating the safety of the PPOS protocol and its impact on neonatal birth outcomes. METHODS: This prospective cohort study was conducted at the Assisted Reproductive Medicine Department of the Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, from January 2020 to December 2023. The study included infertile patients who underwent in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment, followed by frozen embryo transfer. To balance baseline characteristics and ensure a fair comparison, a combination of propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) was employed. PSM and IPTW were used to match patients based on baseline characteristics, including age, body mass index (BMI), infertility duration, hormone levels (FSH, LH, E2), pregnancy history, and other factors. RESULTS: The study compared the outcomes of IVF/ICSI using PPOS and GnRH antagonist protocols. After propensity score matching, 1,950 patients were included in each group. No significant differences were observed between the PPOS and GnRH antagonist groups in clinical pregnancy rate (46.26% vs. 46.21%, P = 0.979), live birth rate (36.26% vs. 35.49%, P = 0.550), miscarriage rate (10.05% vs. 10.72%, P = 0.375), or ectopic pregnancy rate (0.82% vs. 0.82%, P = 0.880). There were no significant differences were found between the two protocols in neonatal outcomes, including sex distribution and incidence of congenital anomalies. Further analysis of singleton live births showed no significant differences in the risk of low birth weight between groups (4.86% vs. 3.16%, adjusted OR = 1.62, 95% CI: 0.97-2.71, P = 0.063) or congenital anomalies (2.35% vs. 1.58%, adjusted OR = 0.67, 95% CI: 0.32-1.39, P = 0.278). In IVF/ICSI treatment, the PPOS protocol showed similar live birth rates and neonatal health outcomes compared to the GnRH antagonist protocol. INNOVATION AND CONTRIBUTION: This prospective cohort study observed patients undergoing IVF/ICSI treatment with either the PPOS or GnRH antagonist protocols, ensuring a fair comparison. PSM and IPTW were used to balance baseline characteristics and adjust for remaining differences, thereby improving the reliability of the results. A key strength lies in the large matched sample, which enhances statistical power. Additionally, unlike previous studies, this research included neonatal outcomes, offering a more comprehensive evaluation of both pregnancy success and infant health. The combination of advanced statistical methods and a focus on long-term outcomes renders this study a significant contribution to the field of infertility treatment. CI - (c) 2025. The Author(s). FAU - Yang, Chuning AU - Yang C AD - Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China. AD - Sejong University, Seoul, Republic of Korea. FAU - Chen, Qiuju AU - Chen Q AD - Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China. FAU - Shen, Xi AU - Shen X AD - Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China. FAU - Guo, Haiyan AU - Guo H AD - Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China. FAU - Lin, Jiaying AU - Lin J AD - Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China. FAU - Lu, Xuefeng AU - Lu X AD - Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China. FAU - Wen, Xiaowei AU - Wen X AD - Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China. 506161005@qq.com. AD - Xi'an Jiaotong-Liverpool University, Suzhou, China. 506161005@qq.com. FAU - Zhu, Qianqian AU - Zhu Q AD - Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China. qianqianzhu1988@126.com. FAU - Chai, Weiran AU - Chai W AD - Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China. chaiwrcn@163.com. LA - eng GR - JYLJ202002/Clinical Research Promotion Program/ PT - Journal Article DEP - 20251127 PL - England TA - J Ovarian Res JT - Journal of ovarian research JID - 101474849 RN - 33515-09-2 (Gonadotropin-Releasing Hormone) RN - 0 (Progestins) RN - 0 (Hormone Antagonists) SB - IM EIN - J Ovarian Res. 2026 Feb 18;19(1):65. doi: 10.1186/s13048-026-02020-1. PMID: 41709325 MH - Humans MH - Female MH - Pregnancy MH - *Ovulation Induction/methods MH - *Fertilization in Vitro/methods MH - Adult MH - *Gonadotropin-Releasing Hormone/antagonists & inhibitors MH - Prospective Studies MH - *Sperm Injections, Intracytoplasmic/methods MH - Pregnancy Outcome MH - *Progestins/pharmacology/therapeutic use MH - Pregnancy Rate MH - Infant, Newborn MH - *Hormone Antagonists/therapeutic use MH - Embryo Transfer PMC - PMC12750736 OTO - NOTNLM OT - Assisted reproductive technology OT - FET OT - GnRH antagonist OT - ICSI OT - IVF OT - Live birth rate OT - PPOS COIS- Declarations. Ethics approval and consent to participate: All participants provided written informed consent prior to enrollment. The study protocol was approved by the Ethics Committee of the Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine (approval number: SH9H-2020-T351-2), and all procedures were conducted in accordance with the Declaration of Helsinki. Consent for publication: This manuscript is original, has not been published or submitted elsewhere, and is not under consideration by any other journal. All authors approved the final version and consent to its submission. All participants provided written informed consent for the publication of this manuscript. Competing interests: The authors declare no competing interests. Clinical trial number: This study is not a registered clinical trial. Therefore, clinical trial number: not applicable. EDAT- 2025/11/28 06:27 MHDA- 2025/12/31 07:37 PMCR- 2025/11/27 CRDT- 2025/11/28 00:16 PHST- 2025/04/10 00:00 [received] PHST- 2025/10/28 00:00 [accepted] PHST- 2025/12/31 07:37 [medline] PHST- 2025/11/28 06:27 [pubmed] PHST- 2025/11/28 00:16 [entrez] PHST- 2025/11/27 00:00 [pmc-release] AID - 10.1186/s13048-025-01885-y [pii] AID - 1885 [pii] AID - 10.1186/s13048-025-01885-y [doi] PST - epublish SO - J Ovarian Res. 2025 Nov 27;18(1):313. doi: 10.1186/s13048-025-01885-y. PMID- 41310718 OWN - NLM STAT- MEDLINE DCOM- 20251128 LR - 20260908 IS - 1475-2840 (Electronic) IS - 1475-2840 (Linking) VI - 24 IP - 1 DP - 2025 Nov 27 TI - Plasma inflammatory proteome profiles identify MASLD among children with overweight or obesity. PG - 450 LID - 10.1186/s12933-025-03011-0 [doi] LID - 450 AB - BACKGROUND & AIMS: Pediatric metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly prevalent among children with overweight or obesity, yet its early diagnosis remains a major clinical challenge. This study aimed to identify circulating inflammatory proteins associated with MASLD and to develop a proteomic risk score (ProScore) to improve diagnostic accuracy. METHODS: In this cross-sectional study of 161 children (median age 8.5 years) with overweight or obesity, MASLD was assessed by vibration-controlled transient elastography, with 42 cases identified. Plasma concentrations of 92 inflammation-related proteins were quantified using a high-throughput proximity extension assay. The ProScore was compared with eleven conventional anthropometric/metabolic indices (WHtR, METS-IR, SPISE, PNFI, VAI, LAP, TyG, TyG-ALT, TyG-WC, TyG-WHtR, and TyG-BMI) and a genetic risk score (GRS). Six machine learning algorithms were employed and diagnostic performance was assessed using area under the curve (AUC) with fivefold cross-validation. RESULTS: Fifteen proteins were significantly associated with MASLD. A six-protein panel (FGF-21, CDCP1, CD244, OPG, Flt3L, MCP-1) achieved the highest diagnostic accuracy (AUC = 0.84), exceeding that of all conventional indices (AUC = 0.65-0.78; all P < 0.05). ProScore performance remained robust in school-based validation (AUC = 0.83), with no substantial improvement when combined with conventional indices. Diagnostic accuracy was higher in children with lower GRS (AUC = 0.92) than in those with higher GRS (AUC = 0.80; P = 0.003). CONCLUSIONS: A proteomic signature of systemic inflammation provides accurate, non-invasive identification of MASLD in at-risk children, outperforming conventional metabolic and genetic tools, and may have utility in clinical and public health settings. CI - (c) 2025. The Author(s). FAU - Wang, Youxin AU - Wang Y AUID- ORCID: 0009-0002-3340-8961 AD - Department of Maternal and Child Health, School of Public Health, Peking University/National Health Commission Key Laboratory of Reproductive Health, Xueyuan Rd 38, Haidian District, Beijing, 100191, China. FAU - Huang, Daniel Q AU - Huang DQ AD - Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. AD - Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore, Singapore. FAU - Zhang, Pingping AU - Zhang P AD - Ningbo Centre for Healthy Lifestyle Research, Chronic Disease Management Office, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Haishu District, Ningbo, 315000, Zhejiang Province, China. FAU - Wang, Mingyue AU - Wang M AD - Department of Maternal and Child Health, School of Public Health, Peking University/National Health Commission Key Laboratory of Reproductive Health, Xueyuan Rd 38, Haidian District, Beijing, 100191, China. FAU - Wu, Yuying AU - Wu Y AD - Department of Maternal and Child Health, School of Public Health, Peking University/National Health Commission Key Laboratory of Reproductive Health, Xueyuan Rd 38, Haidian District, Beijing, 100191, China. FAU - Nur, Enkar AU - Nur E AD - Department of Maternal and Child Health, School of Public Health, Peking University/National Health Commission Key Laboratory of Reproductive Health, Xueyuan Rd 38, Haidian District, Beijing, 100191, China. FAU - Li, Li AU - Li L AD - Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang Province, China. lilyningbo@163.com. FAU - Wang, Hui AU - Wang H AUID- ORCID: 0000-0002-7639-5702 AD - Department of Maternal and Child Health, School of Public Health, Peking University/National Health Commission Key Laboratory of Reproductive Health, Xueyuan Rd 38, Haidian District, Beijing, 100191, China. huiwang@bjmu.edu.cn. LA - eng GR - 202406010169/Program of China Scholarship Council in National University of Singapore/ GR - 2025KY1315/Medical Health Science and Technology Project of Zhejiang Province/ GR - WKJ-ZJ-2216/Major Science and Technology Projects for Health of Zhejiang Province/ GR - LTGY24H260007/Zhejiang Provincial Natural Science Foundation of China/ GR - 2022-B126/Cyrus Tang Foundation/ PT - Journal Article DEP - 20251127 PL - England TA - Cardiovasc Diabetol JT - Cardiovascular diabetology JID - 101147637 RN - 0 (Biomarkers) RN - 0 (Proteome) RN - 0 (Inflammation Mediators) SB - IM MH - Humans MH - Male MH - Female MH - *Pediatric Obesity/blood/diagnosis/epidemiology MH - Cross-Sectional Studies MH - Child MH - Biomarkers/blood MH - *Proteomics/methods MH - *Proteome MH - *Inflammation Mediators/blood MH - Risk Factors MH - Predictive Value of Tests MH - Adolescent MH - Risk Assessment MH - Age Factors MH - Reproducibility of Results MH - *Fatty Liver/blood/diagnosis/epidemiology MH - Elasticity Imaging Techniques MH - Child, Preschool MH - Early Diagnosis PMC - PMC12659286 OTO - NOTNLM OT - Genetic risk score OT - Inflammatory proteome OT - MASLD OT - Non-invasive indices OT - Pediatrics COIS- Declarations. Conflict of interest: Daniel Q. Huang has served as an advisory board member for Gilead and Roche. All other authors do not have any conflicts of interest. EDAT- 2025/11/28 06:27 MHDA- 2025/11/28 06:28 PMCR- 2025/11/27 CRDT- 2025/11/28 00:12 PHST- 2025/08/16 00:00 [received] PHST- 2025/11/04 00:00 [accepted] PHST- 2025/11/28 06:28 [medline] PHST- 2025/11/28 06:27 [pubmed] PHST- 2025/11/28 00:12 [entrez] PHST- 2025/11/27 00:00 [pmc-release] AID - 10.1186/s12933-025-03011-0 [pii] AID - 3011 [pii] AID - 10.1186/s12933-025-03011-0 [doi] PST - epublish SO - Cardiovasc Diabetol. 2025 Nov 27;24(1):450. doi: 10.1186/s12933-025-03011-0. PMID- 41310411 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261024 IS - 2473-4446 (Electronic) IS - 2473-3938 (Linking) VI - 10 IP - 4 DP - 2026 Nov TI - Agreement between perceived and objective sleep duration in highly trained young male soccer players. PG - 459-467 LID - 10.1080/24733938.2025.2593866 [doi] AB - This study aimed to assess the agreement between daily self-reported and actigraphy-derived sleep duration in high-level male youth soccer players over a 35-day period. Secondary analyses examined the agreement between daily self-reported sleep duration and objective time in bed (TIB), as well as the agreement between sleep questionnaire responses and averaged actigraphy data. Forty-eight players wore actigraphy devices nightly and completed daily sleep diaries for 35 consecutive days. After the monitoring period, players completed the Pittsburgh Sleep Quality Index (PSQI). Agreement was assessed using Bland - Altman analysis. Results showed a mean bias of - 60 min between self-reported and objective sleep duration, with wide limits of agreement (-02:09 to +00:15 h), indicating poor agreement. Similar results were observed when comparing self-reported sleep to objective TIB. PSQI responses overestimated average sleep duration for the same time period by 69 min (LoA: -17 to +154 min). Overall, self-reported sleep duration consistently overestimated sleep duration and failed to meet the predefined threshold for acceptable agreement of 30 min. These findings suggest that daily self-report and questionnaire-based sleep estimates may not be reliable proxies for objective sleep data in youth soccer athletes. While subjective methods may still hold practical utility for routine screening, objective tools should be prioritized for sleep monitoring. FAU - Barreira, Joao AU - Barreira J AUID- ORCID: 0000-0002-2652-8685 AD - Research Center in Sports Sciences, Health Sciences and Human Development, CIDESD, University of Maia, Maia, Portugal. FAU - Brito, Joao AU - Brito J AUID- ORCID: 0000-0003-1301-1078 AD - FPF Academy, Portuguese Football Federation, Oeiras, Portugal. AD - CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, Oeiras, Portugal. FAU - Yuzo Nakamura, Fabio AU - Yuzo Nakamura F AUID- ORCID: 0000-0002-5336-3652 AD - Research Center in Sports Sciences, Health Sciences and Human Development, CIDESD, University of Maia, Maia, Portugal. FAU - Pimenta, Ricardo AU - Pimenta R AUID- ORCID: 0000-0003-0134-5038 AD - CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, Oeiras, Portugal. AD - Research Center of the Polytechnic Institute of Maia (N2i), Maia Polytechnic Institute (IPMAIA), Castelo da Maia, Portugal. AD - Department of Rehabilitation and Optimization of Performance (DROP), Futebol Clube Famalicao - Futebol SAD, Famalicao, Portugal. AD - Porto Biomechanics Laboratory, Faculty of Sport, University of Porto, Porto, Portugal. FAU - Figueiredo, Pedro AU - Figueiredo P AUID- ORCID: 0000-0001-5515-3694 AD - Physical Education Department, College of Education, United Arab Emirates University, Al Ain, UAE. LA - eng PT - Journal Article DEP - 20251127 PL - England TA - Sci Med Footb JT - Science & medicine in football JID - 101724288 SB - IM MH - Humans MH - *Sleep Duration MH - Male MH - *Soccer/physiology MH - Actigraphy MH - Adolescent MH - *Self Report MH - Surveys and Questionnaires MH - *Sleep MH - *Athletes OTO - NOTNLM OT - Actigraphy OT - sleep monitoring OT - subjective OT - well-being EDAT- 2025/11/28 06:28 MHDA- 2026/10/25 03:35 CRDT- 2025/11/28 00:02 PHST- 2026/10/25 03:35 [medline] PHST- 2025/11/28 06:28 [pubmed] PHST- 2025/11/28 00:02 [entrez] AID - 10.1080/24733938.2025.2593866 [doi] PST - ppublish SO - Sci Med Footb. 2026 Nov;10(4):459-467. doi: 10.1080/24733938.2025.2593866. Epub 2025 Nov 27. PMID- 41308702 OWN - NLM STAT- MEDLINE DCOM- 20251210 LR - 20260623 IS - 1096-0260 (Electronic) IS - 0091-7435 (Linking) VI - 202 DP - 2026 Jan TI - The association between outdoor environmental factors in kindergartens and children's moderate-to-vigorous physical activity: A systematic review and meta-analysis. PG - 108473 LID - S0091-7435(25)00257-9 [pii] LID - 10.1016/j.ypmed.2025.108473 [doi] AB - OBJECTIVES: The kindergarten outdoor environment is considered a key factor influencing children's moderate-to-vigorous physical activity (MVPA). However, existing findings remain inconsistent, with varying criteria and no synthesis. METHODS: Associations came from studies employing two common measurement methods: accelerometry and direct observation. Fixed- or random-effects models were applied to calculate pooled correlation coefficients. A systematic search of six databases for studies published 2000-2024 identified 17 articles, and 9 met the inclusion criteria for meta-analysis. All outdoor environmental factors were standardized and categorized using validated observational systems, enabling consistent evaluation of their associations with children's MVPA and facilitating data integration across methods. RESULTS: Open spaces, natural elements, and "ball and object play" were moderately positively associated with children's MVPA. Fixed equipment showed weak positive association, while sedentary environments showed very weak negative association. Direct observation appeared slightly more sensitive than accelerometry in detecting these associations. CONCLUSIONS: Open spaces, natural elements, and "ball and object play" are associated with higher levels of children's MVPA, while sedentary environments are linked to reduced activity. These findings highlight the importance of designing kindergarten outdoor environments that promote children's physical activity and healthy development. Future studies should consider the influence of measurement tool differences on results. CI - Copyright (c) 2024. Published by Elsevier Inc. FAU - Xu, Zilin AU - Xu Z AD - School of Architecture, Xi'an University of Architecture & Technology, Xi'an, Shaanxi Province 710055, China. FAU - Li, Shuting AU - Li S AD - School of Architecture, Xi'an University of Architecture & Technology, Xi'an, Shaanxi Province 710055, China. Electronic address: lishuting@xauat.edu.cn. FAU - Chu, Hui AU - Chu H AD - School of Architecture, Xi'an University of Architecture & Technology, Xi'an, Shaanxi Province 710055, China. FAU - Zhou, Kun AU - Zhou K AD - School of Architecture, Xi'an University of Architecture & Technology, Xi'an, Shaanxi Province 710055, China. LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Systematic Review DEP - 20251125 PL - United States TA - Prev Med JT - Preventive medicine JID - 0322116 SB - IM MH - Humans MH - *Exercise/physiology MH - Accelerometry MH - Child, Preschool MH - *Environment Design MH - *Schools MH - Sedentary Behavior MH - Child OTO - NOTNLM OT - Children OT - Kindergarten OT - MVPA OT - Meta-analysis OT - Outdoor environment COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/11/28 00:27 MHDA- 2025/12/11 01:22 CRDT- 2025/11/27 19:11 PHST- 2025/07/18 00:00 [received] PHST- 2025/11/22 00:00 [revised] PHST- 2025/11/24 00:00 [accepted] PHST- 2025/12/11 01:22 [medline] PHST- 2025/11/28 00:27 [pubmed] PHST- 2025/11/27 19:11 [entrez] AID - S0091-7435(25)00257-9 [pii] AID - 10.1016/j.ypmed.2025.108473 [doi] PST - ppublish SO - Prev Med. 2026 Jan;202:108473. doi: 10.1016/j.ypmed.2025.108473. Epub 2025 Nov 25. PMID- 41305836 OWN - NLM STAT- MEDLINE DCOM- 20251127 LR - 20260515 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 104 IP - 47 DP - 2025 Nov 21 TI - Prediction of child nutritional status using deep neural networks: A cross-sectional study of Egypt DHS data (2005-2014). PG - e46089 LID - 10.1097/MD.0000000000046089 [doi] LID - e46089 AB - Child malnutrition, particularly wasting and undernutrition, remains a pressing public health issue in low- and middle-income countries. Timely prediction of nutritional status using accessible demographic and health indicators can support early interventions. This study explores the use of a deep neural network (DNN) model to predict child nutritional status using nationally representative survey data from Egypt. To develop and evaluate the performance of a DNN model for classifying child nutritional status and to compare its performance against traditional machine learning models, including decision tree and Random Forest classifiers. This is a retrospective cross-sectional study based on pooled data from the Egypt Demographic and Health Surveys conducted in 2005, 2008, and 2014. A total of 36,313 children under the age of 5 with complete anthropometric and demographic data were included. A deep neural network was trained on the Egypt Demographic and Health Surveys dataset using class weighting and synthetic minority oversampling technique to address class imbalance. Performance was assessed using accuracy, precision, recall, harmonic mean of precision and recall (F1-score), and receiver operating characteristic (ROC)-area under the curve (AUC) and compared against decision tree and random forest classifiers. The DNN outperformed all baseline models, achieving an accuracy of 89%, recall of 91%, and an ROC-AUC of 0.95. SHAP analysis revealed that maternal body mass index, child age, birth weight, and household wealth index were the most influential features. The random forest achieved a ROC-AUC of 0.95 but showed lower recall and F1-scores compared to the DNN. The DNN model demonstrated high performance in predicting child nutritional status and shows promise as a public health screening tool. Future work should focus on external validation across different populations and enhanced interpretability for clinical deployment. CI - Copyright (c) 2025 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Hendy, Abdelaziz AU - Hendy A AUID- ORCID: 0000-0003-2960-3465 AD - Department of Maternal and Child Health, College of Nursing, Qassim University, Buraydah, Saudi Arabia. FAU - Ibrahim, Rasha Kadri AU - Ibrahim RK AUID- ORCID: 0000-0002-1066-3436 AD - Nursing Department, Fatima College of Health Sciences, Al Dhafra region, Madinat Zayed, UAE. FAU - Abdelaliem, Sally Mohammed Farghaly AU - Abdelaliem SMF AD - Department of Nursing Management and Education, College of Nursing, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Sultan, Hosny Maher AU - Sultan HM AD - Nursing Department, College of Pharmacy and Health Sciences, Ajman University, Ajman, UAE. FAU - Sinnokrot, Shaban Majed AU - Sinnokrot SM AD - Department of Clinical Nursing, Faculty of Nursing, Zarqa University, Zarqa, Jordan. FAU - Al-Ma'ani, Mohammad AU - Al-Ma'ani M AD - Faculty of Nursing, Philadelphia University, Amman, Jordan. FAU - Alzahrani, Badriah AU - Alzahrani B AD - Department of Social Sciences, College of Arts and Humanities, Jazan University, Jazan, Saudi Arabia. FAU - Ali, Waad Hasan AU - Ali WH AD - Department of Nursing Management and Education, College of Nursing, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Alshammari, Afrah Madyan AU - Alshammari AM AD - Department of Maternal and Child Health Nursing, College of Nursing, Jouf University, Sakaka, Saudi Arabia. FAU - Hendy, Ahmed AU - Hendy A AD - Department of Computational Mathematics and Computer Science, Institute of Natural Sciences and Mathematics, Ural Federal University, Yekaterinburg, Russian Federation. AD - Department of Mechanics and Mathematics, Western Caspian University, Baku, Azerbaijan. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Cross-Sectional Studies MH - Egypt/epidemiology MH - *Nutritional Status MH - Retrospective Studies MH - Female MH - Child, Preschool MH - Infant MH - Male MH - *Neural Networks, Computer MH - ROC Curve MH - Infant, Newborn MH - Health Surveys MH - *Child Nutrition Disorders/epidemiology/diagnosis PMC - PMC12643679 OTO - NOTNLM OT - child nutrition OT - deep neural network OT - health monitoring OT - machine learning OT - wasting COIS- The authors have no conflicts of interest to disclose. EDAT- 2025/11/27 06:28 MHDA- 2025/11/27 06:29 PMCR- 2025/11/21 CRDT- 2025/11/27 01:23 PHST- 2025/01/07 00:00 [received] PHST- 2025/09/28 00:00 [accepted] PHST- 2025/11/27 06:29 [medline] PHST- 2025/11/27 06:28 [pubmed] PHST- 2025/11/27 01:23 [entrez] PHST- 2025/11/21 00:00 [pmc-release] AID - 00005792-202511210-00158 [pii] AID - MD-D-24-16676 [pii] AID - 10.1097/MD.0000000000046089 [doi] PST - ppublish SO - Medicine (Baltimore). 2025 Nov 21;104(47):e46089. doi: 10.1097/MD.0000000000046089. PMID- 41305670 OWN - NLM STAT- MEDLINE DCOM- 20251127 LR - 20251130 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 22 DP - 2025 Nov 20 TI - Design and Validation of the Index of Adherence to the Dietary Guidelines for Chile 2022 (GABAS-Index 17). LID - 10.3390/nu17223621 [doi] LID - 3621 AB - Background/Objectives: Adherence to national dietary guidelines is essential for promoting healthy eating and preventing chronic diseases. In Chile, the 2022 update introduced new evidence-based recommendations, but no validated tool is currently available to assess adherence. The aim of this study was to develop and validate a tool to assess adherence to the updated Chilean dietary guidelines. Methods: For this purpose, five expert judges evaluated the content validity using Aiken's V (V >/= 0.80). Reliability was assessed through a 21-day test-retest in 30 participants (>/=18 years, mean age 38.9 years; 63.3% women) using the Intraclass Correlation Coefficient (ICC(3,1)), a two-way mixed-effects model to assess the absolute agreement of individual measurements, Standard Error of Measurement (SEM), and Minimal Detectable Change (MDC95) at the 95% confidence level. Internal consistency was assessed in 152 participants (>/=18 years) examined via McDonald's omega, and construct validity through confirmatory factor analysis (CFA) using the WLSMV estimator. Results: The GABAS-Index 17 showed high content validity (Aiken's V = 0.93-1.00), good internal consistency (omega = 0.64-0.71), and accurate reliability (ICC = 0.905; SEM < 1; MDC95 = 2.1). Confirmatory factor analysis supported the proposed four-dimensional structure (CFI = 1.00; TLI = 1.02; RMSEA = 0.00), confirming strong factorial validity and internal coherence. Conclusions: These findings support the GABAS-Index 17 as an adequate and reliable tool for assessing adherence to the updated Chilean dietary guidelines. Although some psychometric aspects, such as the factorial structure, could be improved, the instrument performs well for its intended purpose of providing an overall adherence score. Its use can facilitate monitoring dietary patterns, support nutrition research, and inform public health strategies to improve diet quality in the Chilean population. FAU - Ramirez-Contreras, Catalina AU - Ramirez-Contreras C AUID- ORCID: 0000-0002-3691-5136 AD - Departamento de Nutricion y Salud Publica, Facultad de Ciencias de la Salud y de los Alimentos, Universidad del Bio-Bio, Chillan 3780000, Chile. FAU - Crisosto-Alarcon, Jaime AU - Crisosto-Alarcon J AUID- ORCID: 0000-0002-2346-2676 AD - Departamento de Ciencias de la Rehabilitacion en Salud, Facultad de Ciencias de la Salud y de los Alimentos, Universidad del Bio-Bio, Chillan 3780000, Chile. FAU - Parra-Soto, Solange AU - Parra-Soto S AUID- ORCID: 0000-0002-8443-7327 AD - Departamento de Nutricion y Salud Publica, Facultad de Ciencias de la Salud y de los Alimentos, Universidad del Bio-Bio, Chillan 3780000, Chile. FAU - Burdiles-Aguirre, Jorge AU - Burdiles-Aguirre J AUID- ORCID: 0009-0004-3185-4858 AD - Departamento de Ciencias de la Rehabilitacion en Salud, Facultad de Ciencias de la Salud y de los Alimentos, Universidad del Bio-Bio, Chillan 3780000, Chile. FAU - Liabeuf, Gianella AU - Liabeuf G AUID- ORCID: 0000-0003-2995-1283 AD - Departamento de Nutricion y Salud Publica, Facultad de Ciencias de la Salud y de los Alimentos, Universidad del Bio-Bio, Chillan 3780000, Chile. FAU - Briones-Suarez, Lautaro AU - Briones-Suarez L AUID- ORCID: 0000-0002-4830-7349 AD - Departamento de Nutricion y Salud Publica, Facultad de Ciencias de la Salud y de los Alimentos, Universidad del Bio-Bio, Chillan 3780000, Chile. LA - eng PT - Journal Article PT - Validation Study DEP - 20251120 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Chile MH - Female MH - Male MH - Adult MH - *Nutrition Policy MH - Reproducibility of Results MH - Middle Aged MH - Young Adult MH - *Diet, Healthy MH - *Guideline Adherence/statistics & numerical data MH - Adolescent PMC - PMC12655339 OTO - NOTNLM OT - GABAS OT - dietary assessment OT - dietary guidelines OT - nutritional epidemiology OT - validation COIS- The authors declare no conflicts of interest. EDAT- 2025/11/27 06:27 MHDA- 2025/11/27 06:28 PMCR- 2025/11/20 CRDT- 2025/11/27 01:23 PHST- 2025/10/20 00:00 [received] PHST- 2025/11/16 00:00 [revised] PHST- 2025/11/19 00:00 [accepted] PHST- 2025/11/27 06:28 [medline] PHST- 2025/11/27 06:27 [pubmed] PHST- 2025/11/27 01:23 [entrez] PHST- 2025/11/20 00:00 [pmc-release] AID - nu17223621 [pii] AID - nutrients-17-03621 [pii] AID - 10.3390/nu17223621 [doi] PST - epublish SO - Nutrients. 2025 Nov 20;17(22):3621. doi: 10.3390/nu17223621. PMID- 41305658 OWN - NLM STAT- MEDLINE DCOM- 20251127 LR - 20251218 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 22 DP - 2025 Nov 19 TI - Dietary Habits and Nutritional Status in Ecuatorian Children Aged 1-11 Years: A Systematic Review Highlighting the Dual Burden of Malnutrition. LID - 10.3390/nu17223608 [doi] LID - 3608 AB - Background: Background: Childhood dietary habits are critical determinants of physical growth, cognitive development, and long-term health. In Ecuador, malnutrition remains a major public health concern, with both undernutrition and overweight/obesity affecting children-especially in rural and indigenous populations. Methods: This systematic review followed PRISMA 2020 guidelines (PROSPERO ID: CRD420251080987). Searches were conducted in SciELO, Dialnet, and ScienceDirect (accessed August 2025) using Boolean operators to identify quantitative studies in Spanish or English published between 2018 and 2025 that assessed dietary habits and nutritional status in Ecuadorian children aged 1-11 years. Seventeen studies, including approximately 12,000 children, were included. Results: Prevalence of chronic undernutrition ranged from 15% to 35%, while overweight and obesity reached 20-30%. Undernutrition was higher among rural and indigenous children, whereas overweight predominated in urban and higher-income settings. Common dietary patterns included high consumption of ultra-processed foods and sugar-sweetened beverages, and insufficient intake of fruits, vegetables, and quality proteins. Maternal education, socioeconomic level, and school food environments were key determinants. Conclusions: Both malnutrition and overweight persist among Ecuadorian children, reflecting a nutrition transition influenced by socioeconomic and environmental factors. Context-specific public health actions are urgently needed, including school-based nutrition education, regulation of food marketing, improved access to affordable healthy foods, and community-level engagement to promote sustainable dietary habits. The included studies were mostly cross-sectional and often used non-validated dietary assessment tools, which may influence the reported prevalence estimates. FAU - Micoanski, Keila S AU - Micoanski KS AUID- ORCID: 0009-0006-8051-2437 AD - Area of Nutrition and Bromatology, Department of Medicine and Public Health, Food Science, Toxicology, and Legal Medicine, Faculty of Pharmacy and Food Sciences, University of Valencia, Av. Vicent Andres Estelles, 22, 46010 Burjassot, Spain. FAU - Izquierdo-Garcia, Cristina AU - Izquierdo-Garcia C AD - Area of Parasitology, Department of Pharmacy and Pharmaceutical Technology and Parasitology, Faculty of Pharmacy and Food Sciences, University of Valencia, Av. Vicent Andres Estelles, 22, 46010 Burjassot, Spain. FAU - Huacho-Jacome, Alex S AU - Huacho-Jacome AS AD - Faculty of Public Health, Escuela Superior Politecnica de Chimborazo, Riobamba 060101, Ecuador. FAU - Trelis, Maria AU - Trelis M AUID- ORCID: 0000-0002-5977-3337 AD - Area of Parasitology, Department of Pharmacy and Pharmaceutical Technology and Parasitology, Faculty of Pharmacy and Food Sciences, University of Valencia, Av. Vicent Andres Estelles, 22, 46010 Burjassot, Spain. FAU - Gozalbo, Monica AU - Gozalbo M AUID- ORCID: 0000-0002-6299-7665 AD - Area of Nutrition and Bromatology, Department of Medicine and Public Health, Food Science, Toxicology, and Legal Medicine, Faculty of Pharmacy and Food Sciences, University of Valencia, Av. Vicent Andres Estelles, 22, 46010 Burjassot, Spain. LA - eng GR - 20240242/Proyecto de Cooperacion al Desarrollo del Vicerrectorat de Sostenibilitat, Cooperacio i Vida saludable from the Universitat de Valencia-Estudi General (Valencia, Spain)/ PT - Journal Article PT - Systematic Review DEP - 20251119 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Ecuador/epidemiology MH - *Nutritional Status MH - Child, Preschool MH - Infant MH - Child MH - *Feeding Behavior MH - Male MH - Female MH - Prevalence MH - *Malnutrition/epidemiology MH - Pediatric Obesity/epidemiology MH - *Diet MH - *Child Nutrition Disorders/epidemiology MH - Socioeconomic Factors MH - Rural Population PMC - PMC12655085 OTO - NOTNLM OT - Ecuador OT - childhood OT - eating habits OT - nutritional status OT - systematic review COIS- The authors declare no conflicts of interest. EDAT- 2025/11/27 06:27 MHDA- 2025/11/27 06:28 PMCR- 2025/11/19 CRDT- 2025/11/27 01:23 PHST- 2025/09/25 00:00 [received] PHST- 2025/11/01 00:00 [revised] PHST- 2025/11/10 00:00 [accepted] PHST- 2025/11/27 06:28 [medline] PHST- 2025/11/27 06:27 [pubmed] PHST- 2025/11/27 01:23 [entrez] PHST- 2025/11/19 00:00 [pmc-release] AID - nu17223608 [pii] AID - nutrients-17-03608 [pii] AID - 10.3390/nu17223608 [doi] PST - epublish SO - Nutrients. 2025 Nov 19;17(22):3608. doi: 10.3390/nu17223608. PMID- 41305655 OWN - NLM STAT- MEDLINE DCOM- 20260429 LR - 20260429 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 22 DP - 2025 Nov 18 TI - Maternal Pressure and Frequent Use of Bottle During Feeding Moderate Infant Food Cue Reactivity over Time. LID - 10.3390/nu17223605 [doi] LID - 3605 AB - Background: Food cue reactivity (FCR) has been associated with a higher obesity risk, but little is known about what factors influence FCR during infancy. This study examined the moderating effects of maternal feeding styles and bottle feeding on the associations between 2-month and 6-month FCR. Methods: Data came from 299 mother-infant dyads who participated in a larger early-obesity-risk study and provided information via online questionnaires (i.e., socio-demographics) and/or during lab visits (i.e., anthropometrics) prenatally and at 2 and 6 months postpartum. Food-related practices (i.e., bottle use, milk type), feeding styles and FCR were measured by previously validated mother-reported measures: Infant Feeding Practices, Infant Feeding Styles, and Baby Eating Behavior Questionnaires. A regression model with moderation effects between 2-month FCR, feeding styles, and bottle feeding on 6-month FCR was tested using Mplus, controlling for selected variables (i.e., milk type, infant birthweight). Maternal pressure interacted with 2-month FCR and bottle feeding to predict 6-month FCR. Results: The moderating role of higher pressure was significant only for infants who received most of their feeds via a bottle ("high" bottle feeding). No other interactions were significant. Maternal feeding pressure in combination with frequent bottle feeding further strengthens the positive association between early and late FCR in infancy. Conclusions: Given the previously established links between FCR and weight outcomes among children, reducing the controlling maternal feeding practice of pressure during feeding in infancy, especially among mothers who frequently bottle feed, might be an important intervention target for optimizing weight outcomes in the first year of life. FAU - Shriver, Lenka H AU - Shriver LH AUID- ORCID: 0000-0002-3125-333X AD - Department of Nutrition, University of North Carolina at Greensboro, P.O. Box 26170, Greensboro, NC 27402-6170, USA. FAU - Chen, Yu AU - Chen Y AUID- ORCID: 0000-0001-7269-3350 AD - Department of Human Development and Family Studies, University of North Carolina at Greensboro, P.O. Box 26170, Greensboro, NC 27402-6170, USA. FAU - Buehler, Cheryl AU - Buehler C AD - Department of Human Development and Family Studies, University of North Carolina at Greensboro, P.O. Box 26170, Greensboro, NC 27402-6170, USA. FAU - Wideman, Laurie AU - Wideman L AUID- ORCID: 0000-0001-5100-7657 AD - Department of Kinesiology, University of North Carolina at Greensboro, P.O. Box 26170, Greensboro, NC 27402-6170, USA. FAU - Leerkes, Esther M AU - Leerkes EM AUID- ORCID: 0000-0002-8181-6452 AD - Department of Human Development and Family Studies, University of North Carolina at Greensboro, P.O. Box 26170, Greensboro, NC 27402-6170, USA. LA - eng GR - R01HD093662/National Institute of Child Health and Human Development/ PT - Journal Article DEP - 20251118 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Surveys and Questionnaires MH - Anthropometry MH - Risk Factors MH - Humans MH - Male MH - Female MH - Infant MH - Adult MH - Cues MH - *Bottle Feeding/psychology MH - *Maternal Behavior/psychology MH - *Infant Behavior/psychology MH - Pediatric Obesity/diagnosis/etiology/prevention & control MH - *Mother-Child Relations/psychology MH - *Infant Food MH - Southeastern United States MH - Middle Aged PMC - PMC12655122 OTO - NOTNLM OT - bottle feeding OT - feeding style OT - food cue reactivity OT - infancy OT - pressure COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study, in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2025/11/27 06:28 MHDA- 2025/11/27 06:29 PMCR- 2025/11/18 CRDT- 2025/11/27 01:23 PHST- 2025/10/21 00:00 [received] PHST- 2025/11/15 00:00 [revised] PHST- 2025/11/17 00:00 [accepted] PHST- 2025/11/27 06:29 [medline] PHST- 2025/11/27 06:28 [pubmed] PHST- 2025/11/27 01:23 [entrez] PHST- 2025/11/18 00:00 [pmc-release] AID - nu17223605 [pii] AID - nutrients-17-03605 [pii] AID - 10.3390/nu17223605 [doi] PST - epublish SO - Nutrients. 2025 Nov 18;17(22):3605. doi: 10.3390/nu17223605. PMID- 41305600 OWN - NLM STAT- MEDLINE DCOM- 20260429 LR - 20260429 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 22 DP - 2025 Nov 13 TI - Adolescent Eating Disorder Risk in a Bilingual Region: Clinical Prevalence, Screening Challenges and Treatment Gap in South Tyrol, Italy. LID - 10.3390/nu17223549 [doi] LID - 3549 AB - Background/Objectives: Eating disorders (EDs) in adolescents are increasingly prevalent. In South Tyrol, a bilingual region in Northern Italy, not only actual gender and age prevalences can be compared to screening rates, but even the comparability of screening tools across languages can be examined. Methods: A cross-sectional analysis integrated clinical registry data with representative, online school-recruited adolescents (11 to 17) self-reports. 166 clinically diagnosed cases and 1465 screened adolescents (1246 German, 219 Italian), were examined. The SCOFF questionnaire (cutoff >/= 2 for German and >/=3 for Italian), body mass index, body image perception, psychosocial and lifestyle indicators in proxy and self-reports were examined using descriptive statistics and logistic regression. Results: The clinical dataset for 2024 has a prevalence rate of 0.4%. The SCOFF screening tool identified symptomatic cases in 10.6%, and an age-increasing trend among females. The overall SCOFF-prevalence did not differ between language versions, although responses to individual items varied significantly. Predictors of ED included body image, psychosomatic complaints, problematic social media use, and low social support, with differences between genders. Parents tended to underestimate their children's perception of being "too thick." Conclusions: In early adolescence, preventive strategies are needed and targeted interventions in late adolescence. For early detection and intervention, gender-sensitive prevention and active parental involvement is needed. The SCOFF questionnaire demonstrates utility across both languages, but bilingual comparison highlights the need for culturally adapted tools and cross-language validation. FAU - Barbieri, Verena AU - Barbieri V AUID- ORCID: 0000-0002-5934-9472 AD - Institute of General Practice and Public Health, Claudiana College of Health Professions, 39100 Bolzano, Italy. FAU - Zobl, Michael AU - Zobl M AD - Department of Pediatrics, Hospital of Bressanone-Brixen (SABES-ASDAA), 39042 Bressanone, Italy. FAU - Piccoliori, Giuliano AU - Piccoliori G AUID- ORCID: 0000-0003-1974-4184 AD - Institute of General Practice and Public Health, Claudiana College of Health Professions, 39100 Bolzano, Italy. FAU - Engl, Adolf AU - Engl A AD - Institute of General Practice and Public Health, Claudiana College of Health Professions, 39100 Bolzano, Italy. FAU - Hager von Strobele-Prainsack, Doris AU - Hager von Strobele-Prainsack D AD - Institute of General Practice and Public Health, Claudiana College of Health Professions, 39100 Bolzano, Italy. FAU - Wiedermann, Christian J AU - Wiedermann CJ AUID- ORCID: 0000-0002-4639-8195 AD - Institute of General Practice and Public Health, Claudiana College of Health Professions, 39100 Bolzano, Italy. LA - eng PT - Journal Article PT - Observational Study DEP - 20251113 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Female MH - Adolescent MH - Risk Factors MH - *Multilingualism MH - Italy/epidemiology MH - *Feeding and Eating Disorders/diagnosis/epidemiology/ethnology/therapy MH - *Mass Screening/methods/statistics & numerical data MH - Registries MH - Surveys and Questionnaires MH - Logistic Models MH - Cross-Sectional Studies MH - Child MH - Prevalence MH - Body Image/psychology MH - Parents/psychology MH - Sex Factors MH - Feeding Behavior/ethnology/psychology MH - Body Mass Index PMC - PMC12655724 OTO - NOTNLM OT - German OT - Italian OT - SCOFF questionnaire OT - adolescent health OT - body image OT - body mass index OT - cross-cultural screening OT - parental perception OT - psychosomatic complaints OT - social media use COIS- The authors declare no conflicts of interest. EDAT- 2025/11/27 06:28 MHDA- 2025/11/27 06:29 PMCR- 2025/11/13 CRDT- 2025/11/27 01:22 PHST- 2025/10/14 00:00 [received] PHST- 2025/11/07 00:00 [revised] PHST- 2025/11/12 00:00 [accepted] PHST- 2025/11/27 06:29 [medline] PHST- 2025/11/27 06:28 [pubmed] PHST- 2025/11/27 01:22 [entrez] PHST- 2025/11/13 00:00 [pmc-release] AID - nu17223549 [pii] AID - nutrients-17-03549 [pii] AID - 10.3390/nu17223549 [doi] PST - epublish SO - Nutrients. 2025 Nov 13;17(22):3549. doi: 10.3390/nu17223549. PMID- 41305567 OWN - NLM STAT- MEDLINE DCOM- 20251127 LR - 20251130 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 22 DP - 2025 Nov 11 TI - Development and Psychometric Evaluation of the Transtheoretical Model-Based Sustainable Nutrition Behavior Scale (TTM-SNBS) for Adolescents. LID - 10.3390/nu17223516 [doi] LID - 3516 AB - Background/Objectives: Sustainable nutrition is essential for human and planetary health. The Transtheoretical Model-based Sustainable Nutrition Behavior Scale (TTM-SNBS) was developed to assess sustainable nutrition behaviors and the dynamic processes of behavior change in adolescents. Methods: The item pool was generated through literature review and expert consultation using the Delphi technique (10 experts, three rounds). Construct validity was assessed using exploratory and confirmatory factor analyses. Reliability was evaluated through Cronbach's alpha and test-retest methods. External validity was examined through correlations with the Sustainable and Healthy Eating Behaviors Scale (SHEBS), following COSMIN standards. The study included 512 adolescents aged 14-18 years (54% female) from public high schools in Ankara, Turkiye. Results: Initially, 75 items were developed through expert evaluation. After preliminary testing, two items with low and negative correlations were removed; 73 were retained for validation. Factor analyses and refinement produced a 45-item final validated scale comprising one stage of change item and five subscales: cognitive processes (14 items), behavioral processes (18 items), decisional balance-pros (4 items), decisional balance-cons (4 items), and self-efficacy (4 items). Items showed good discrimination (>0.27). Cronbach's alpha values ranged from 0.67 to 0.93, and fit indices were acceptable (chi(2)/df = 2.8-4.2; RMSEA = 0.045-0.065). External validity was supported by significant positive correlations with the SHEBS. Conclusions: The TTM-SNBS is the first psychometrically validated, theory-based instrument to assess sustainable nutrition behaviors in adolescents. It offers a reliable and valid instrument to support future research and interventions promoting sustainable dietary practices. FAU - Muslu, Ozlem AU - Muslu O AUID- ORCID: 0000-0001-6940-3471 AD - Department of Nutrition and Dietetics, Institute of Health Sciences, Erciyes University, Kayseri 38280, Turkiye. AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Yuksek Ihtisas University, Ankara 06530, Turkiye. FAU - Demir, Pervin AU - Demir P AUID- ORCID: 0000-0002-6652-0290 AD - Department of Biostatistics and Medical Informatics, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara 06010, Turkiye. FAU - Caferoglu Akin, Zeynep AU - Caferoglu Akin Z AUID- ORCID: 0000-0002-7226-5636 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Erciyes University, Kayseri 38280, Turkiye. AD - Department of Health Sciences, University of York, York YO10 5DD, UK. FAU - Basdas, Oznur AU - Basdas O AD - Department of Nursing, Faculty of Health Sciences, Erciyes University, Kayseri 38280, Turkiye. LA - eng PT - Journal Article PT - Validation Study DEP - 20251111 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - Female MH - *Psychometrics MH - Male MH - Reproducibility of Results MH - *Adolescent Behavior/psychology MH - *Transtheoretical Model MH - *Feeding Behavior/psychology MH - *Diet, Healthy/psychology MH - *Health Behavior MH - Factor Analysis, Statistical MH - Surveys and Questionnaires MH - Delphi Technique MH - Self Efficacy PMC - PMC12655102 OTO - NOTNLM OT - adolescents OT - behavior change OT - public health OT - scale development OT - sustainable nutrition OT - transtheoretical model OT - validity COIS- The authors declare no conflicts of interest. EDAT- 2025/11/27 06:28 MHDA- 2025/11/27 06:29 PMCR- 2025/11/11 CRDT- 2025/11/27 01:22 PHST- 2025/10/10 00:00 [received] PHST- 2025/11/04 00:00 [revised] PHST- 2025/11/07 00:00 [accepted] PHST- 2025/11/27 06:29 [medline] PHST- 2025/11/27 06:28 [pubmed] PHST- 2025/11/27 01:22 [entrez] PHST- 2025/11/11 00:00 [pmc-release] AID - nu17223516 [pii] AID - nutrients-17-03516 [pii] AID - 10.3390/nu17223516 [doi] PST - epublish SO - Nutrients. 2025 Nov 11;17(22):3516. doi: 10.3390/nu17223516. PMID- 41303091 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251127 LR - 20251130 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 14 IP - 22 DP - 2025 Nov 13 TI - Magnetic Resonance Imaging of Musculoskeletal Manifestations in Sickle Cell Disease. LID - 10.3390/jcm14228056 [doi] LID - 8056 AB - Background: Sickle cell disease (SCD) affects more than 100,000 people in the United States and 8 million people worldwide, with high morbidity and mortality and musculoskeletal (MSK) complications that contribute to functional disability. However, MRI-based characterization of musculoskeletal manifestations remains limited in high-prevalence regions, including the Middle East. This study aimed to review MRI findings of MSK manifestations in SCD patients and assess associations with clinical characteristics. Methods: A retrospective study was conducted on 96 patients with SCD who underwent MSK MRI between 2012 and 2022 at King Abdulaziz University Hospital. Patient demographics, clinical characteristics, and imaging findings were reviewed. The prevalence and distribution of MSK complications were analyzed across age, gender, and BMI categories. Results: Of the 96 patients (47% males; 53% females; mean age 28.9 years), the hip was the most frequently scanned region (46%), followed by the leg, femur, shoulder, and knee. Bone infarction was the most common complication, observed in 57 patients (59.3%), and was more prevalent among older adults. Osteomyelitis was identified in 16 patients (16.7%), with higher rates in children and underweight individuals. Decreased bone marrow signal intensity was seen in 11 patients (11.4%), particularly in older age groups. Other findings and unremarkable scans each accounted for 6 cases (6.3%). Gender analysis showed broadly similar patterns, although decreased marrow signal intensity was more common in females. Conclusions: MRI is an effective imaging modality for detecting and differentiating MSK complications in SCD. Routine use of MRI in follow-up care is recommended to facilitate early diagnosis, guide management, and prevent long-term disability. Larger prospective studies are needed to validate these findings and establish MRI as a routine diagnostic tool for SCD. FAU - Alsalah, Jaber Hussain AU - Alsalah JH AD - Department of Radiological Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia. AD - Smart Medical Imaging Research Group, King Abdulaziz University, Jeddah 21589, Saudi Arabia. AD - King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia. LA - eng GR - IFIP00/King Abdulaziz University/ PT - Journal Article DEP - 20251113 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC12653726 OTO - NOTNLM OT - MSK MRI OT - imaging patterns OT - musculoskeletal manifestations OT - sickle cell disease COIS- The author declares no conflicts of interest. EDAT- 2025/11/27 06:28 MHDA- 2025/11/27 06:29 PMCR- 2025/11/13 CRDT- 2025/11/27 01:13 PHST- 2025/10/02 00:00 [received] PHST- 2025/11/02 00:00 [revised] PHST- 2025/11/12 00:00 [accepted] PHST- 2025/11/27 06:29 [medline] PHST- 2025/11/27 06:28 [pubmed] PHST- 2025/11/27 01:13 [entrez] PHST- 2025/11/13 00:00 [pmc-release] AID - jcm14228056 [pii] AID - jcm-14-08056 [pii] AID - 10.3390/jcm14228056 [doi] PST - epublish SO - J Clin Med. 2025 Nov 13;14(22):8056. doi: 10.3390/jcm14228056. PMID- 41302609 OWN - NLM STAT- MEDLINE DCOM- 20251127 LR - 20260825 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 22 IP - 11 DP - 2025 Nov 2 TI - Agreement Between Consumer and Research-Grade Physical Activity Monitors in a Public Health Intervention for Adolescent Latinas. LID - 10.3390/ijerph22111663 [doi] LID - 1663 AB - Consumer wearables are increasingly used in physical activity (PA) interventions, but their validity as a measurement tool among low PA groups, like adolescent girls, is unclear. We assessed the minute- and day-level agreement between PA measures among adolescent Latinas from an intervention. Participants wore a Fitbit Inspire HR and an ActiGraph GT3X+ for overlapping epochs. ActiGraph data were classified using two different cut points and aligned with Fitbit data to produce 1,149,169 matched minutes of wear across 137 adolescent girls (M = 15.73 yrs). Confusion matrices were calculated for pairwise comparisons to determine minute-level Moderate-Vigorous PA (MVPA) classification. Data were aggregated to 1007 days for Bland-Altman analyses. ActiGraph cut points showed moderate agreement for minute-level MVPA classification (Balanced Accuracy = 0.71, AC1 = 0.98), while Fitbit showed fair agreement (Balanced Accuracy = 0.50, AC1 = 0.95-0.97) largely driven by non-MVPA observations. The Freedson cut point overestimated daily MVPA relative to Treuth by 14.7 min/day and Fitbit by 14.2 min/day in Bland-Altman space. The daily Treuth and Fitbit comparison did not significantly differ. Findings suggest systematic differences between cut points that warrant further consideration. Fitbit showed moderate agreement with ActiGraph, but heteroscedasticity and the epoch of aggregation significantly impacted agreement. Understanding device differences has implications for promoting/researching public health among adolescents. FAU - Carson, Jacob AU - Carson J AUID- ORCID: 0000-0003-0803-2341 AD - Herbert Wertheim School of Public Health & Human Longevity Science, University of California, La Jolla, San Diego, CA 92093, USA. FAU - Wing, David AU - Wing D AUID- ORCID: 0000-0003-1883-9448 AD - Herbert Wertheim School of Public Health & Human Longevity Science, University of California, La Jolla, San Diego, CA 92093, USA. AD - Exercise and Physical Activity Resource Center, University of California, San Diego, CA 92093, USA. FAU - Godino, Job G AU - Godino JG AUID- ORCID: 0000-0002-4852-6277 AD - Herbert Wertheim School of Public Health & Human Longevity Science, University of California, La Jolla, San Diego, CA 92093, USA. AD - Exercise and Physical Activity Resource Center, University of California, San Diego, CA 92093, USA. AD - Laura Rodriguez Research Institute, Family Health Centers of San Diego, San Diego, CA 92101, USA. FAU - Higgins, Michael AU - Higgins M AUID- ORCID: 0000-0001-9639-3352 AD - Herbert Wertheim School of Public Health & Human Longevity Science, University of California, La Jolla, San Diego, CA 92093, USA. AD - Exercise and Physical Activity Resource Center, University of California, San Diego, CA 92093, USA. FAU - Larsen, Britta AU - Larsen B AD - Herbert Wertheim School of Public Health & Human Longevity Science, University of California, La Jolla, San Diego, CA 92093, USA. LA - eng GR - UL1TR001442/Altman Clinical Research Institute/ GR - UL1 TR001442/TR/NCATS NIH HHS/United States GR - 1R01NR017876-05/NH/NIH HHS/United States GR - UM1 TR005449/TR/NCATS NIH HHS/United States GR - T32 HL079891/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20251102 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Adolescent MH - Female MH - Humans MH - *Accelerometry/instrumentation MH - *Actigraphy/instrumentation MH - *Exercise MH - *Hispanic or Latino MH - Public Health PMC - PMC12652026 OTO - NOTNLM OT - MVPA OT - accelerometry OT - activity monitoring OT - consumer wearables COIS- The authors have no conflicts of interest to declare. The results of the study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation. EDAT- 2025/11/27 06:29 MHDA- 2025/11/27 06:30 PMCR- 2025/11/02 CRDT- 2025/11/27 01:11 PHST- 2025/07/29 00:00 [received] PHST- 2025/10/11 00:00 [revised] PHST- 2025/10/31 00:00 [accepted] PHST- 2025/11/27 06:30 [medline] PHST- 2025/11/27 06:29 [pubmed] PHST- 2025/11/27 01:11 [entrez] PHST- 2025/11/02 00:00 [pmc-release] AID - ijerph22111663 [pii] AID - ijerph-22-01663 [pii] AID - 10.3390/ijerph22111663 [doi] PST - epublish SO - Int J Environ Res Public Health. 2025 Nov 2;22(11):1663. doi: 10.3390/ijerph22111663. PMID- 41302378 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251127 LR - 20251130 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 13 IP - 22 DP - 2025 Nov 20 TI - Cross-Cultural Adaptation and Validation of the "Brief Scale of Perceived Barriers to Physical Activity for Children": Analysis of Psychometric Properties. LID - 10.3390/healthcare13222991 [doi] LID - 2991 AB - Background: Physical activity (PA) provides significant health benefits, yet inactivity remains high in Spain, especially among adolescents and increasingly in children. Identifying barriers to PA is essential, but available tools are mainly designed for adolescents. This study aimed to adapt the "Brief Scale of Perceived Barriers to Physical Activity" for Spanish schoolchildren aged 6-12 and examine its validity and reliability. Methods: The "Brief Scale of Perceived Barriers to Physical Activity for Children" was linguistically and culturally adapted. Comprehension was assessed through cognitive interviews, and reliability was examined via a test-retest procedure with 137 Spanish schoolchildren. Several analyses were conducted, including confirmatory factor analysis (CFA) to assess the factor structure, along with reliability metrics: Cronbach's alpha (alpha) for internal consistency and the intraclass correlation coefficient (ICC) for test-retest reliability. Results: CFA confirmed a four-factor structure (self-concept, motivation-interest, social support, and task incompatibility) in a sample of 137 with excellent fit indices (chi(2)/df = 1.394, RMSEA = 0.054, CFI = 0.976, TLI = 0.966). Internal consistency ranged from good to excellent (alpha = 0.831-0.979). Temporal stability was substantial to near perfect (ICC = 0.708-0.979). Measurement error was low for all items and the total score (SEM% = 6.1-37.2; MDC% = 17.0-103.0), demonstrating accuracy. Conclusions: The "Brief Scale of Perceived Barriers to Physical Activity for Children" was proven to be a reliable and valid tool for assessing perceived barriers to PA in Spanish children. It offers developmentally appropriate insights that can guide strategies to enhance supportive environments and promote long-term active behaviours. As part of the social domain, it contributes to the Spanish Physical Literacy Assessment for Children (SPLA-C) model, the first physical literacy (PL) assessment instrument developed in Spain. FAU - Pastor-Cisneros, Raquel AU - Pastor-Cisneros R AUID- ORCID: 0000-0001-7305-6783 AD - Physical Activity for Education, Performance and Health (PAEPH) Research Group, Faculty of Sport Sciences, University of Extremadura, 10003 Caceres, Spain. FAU - Mendoza-Munoz, Maria AU - Mendoza-Munoz M AUID- ORCID: 0000-0001-9502-5486 AD - Department of Communication and Education, Universidad Loyola Andalucia, 41704 Sevilla, Spain. FAU - Rodriguez-Gutierrez, Amparo AU - Rodriguez-Gutierrez A AUID- ORCID: 0009-0007-2728-6239 AD - Research Group on Didactic and Behavioural Analysis in Sport, Faculty of Sports Sciences, University of Extremadura, 10003 Caceres, Spain. FAU - Carlos-Vivas, Jorge AU - Carlos-Vivas J AUID- ORCID: 0000-0002-6377-9950 AD - Physical Activity for Education, Performance and Health (PAEPH) Research Group, Faculty of Sport Sciences, University of Extremadura, 10003 Caceres, Spain. LA - eng PT - Journal Article DEP - 20251120 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12652913 OTO - NOTNLM OT - SPLA-C OT - cultural adaption OT - exercise OT - motivation OT - physical literacy OT - psychometric properties COIS- The authors declare no conflicts of interest. EDAT- 2025/11/27 06:28 MHDA- 2025/11/27 06:29 PMCR- 2025/11/20 CRDT- 2025/11/27 01:10 PHST- 2025/09/28 00:00 [received] PHST- 2025/10/28 00:00 [revised] PHST- 2025/11/08 00:00 [accepted] PHST- 2025/11/27 06:29 [medline] PHST- 2025/11/27 06:28 [pubmed] PHST- 2025/11/27 01:10 [entrez] PHST- 2025/11/20 00:00 [pmc-release] AID - healthcare13222991 [pii] AID - healthcare-13-02991 [pii] AID - 10.3390/healthcare13222991 [doi] PST - epublish SO - Healthcare (Basel). 2025 Nov 20;13(22):2991. doi: 10.3390/healthcare13222991. PMID- 41301377 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251127 LR - 20251130 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 15 IP - 11 DP - 2025 Nov 17 TI - Effect of Active Pedagogical Models on Basic Psychological Needs and Intention to Do Physical Exercise. LID - 10.3390/bs15111574 [doi] LID - 1574 AB - (1) This study examined the influence of pedagogical models and gender on basic psychological needs and intention to engage in physical exercise during the teaching of an alternative invasive sport. (2) Participants were 136 students from the fifth and sixth grades of Primary Education and the first grade of Secondary Education (M = 11.36; SD = 1.04). Two programs were implemented per grade: one following the Game-Centered Model, and another based on a hybrid model combining the Game-Centered Model and the Sports Education Model. Autonomy, competence, and relatedness were assessed using the Basic Psychological Needs in Physical Exercise Scale, while exercise intention was evaluated with the Intentionality to Be Physically Active Scale. Psychometric properties were verified through confirmatory factor analysis, Cronbach's alpha, mean variance extracted, and composite reliability. Descriptive and inferential analyses were conducted using the linear mixed model and Bonferroni's post hoc test. (3) Both pedagogical models improved all variables. The hybrid model yielded significantly higher autonomy. Gender differences were observed in relatedness, with boys reporting greater values. (4) The pedagogical models used favor the satisfaction of basic psychological needs and exercise intention. Teachers should integrate psychological needs into programs for improvements in intention to be physically active, positively impacting self-determined participation. FAU - Calle, Olga AU - Calle O AUID- ORCID: 0000-0001-6757-0161 AD - Training Optimization and Sport Performance Research Group (GOERD), Sport Science Faculty, University of Extremadura, 10005 Caceres, Spain. AD - Faculty of Sport Sciences, University of Extremadura, 10003 Caceres, Spain. FAU - Antunez, Antonio AU - Antunez A AUID- ORCID: 0000-0002-7451-4448 AD - Training Optimization and Sport Performance Research Group (GOERD), Sport Science Faculty, University of Extremadura, 10005 Caceres, Spain. AD - Faculty of Sport Sciences, University of Extremadura, 10003 Caceres, Spain. FAU - Ibanez, Sergio Jose AU - Ibanez SJ AUID- ORCID: 0000-0001-6009-4086 AD - Training Optimization and Sport Performance Research Group (GOERD), Sport Science Faculty, University of Extremadura, 10005 Caceres, Spain. AD - Faculty of Sport Sciences, University of Extremadura, 10003 Caceres, Spain. FAU - Feu, Sebastian AU - Feu S AUID- ORCID: 0000-0003-2959-5960 AD - Training Optimization and Sport Performance Research Group (GOERD), Sport Science Faculty, University of Extremadura, 10005 Caceres, Spain. AD - Faculty of Education and Psychology, University of Extremadura, 06006 Badajoz, Spain. LA - eng GR - FPU20/02939/Ministerio de Ciencia, Innovacion y Universidades/ GR - Research Group Support Grant (GR24133)./European Union through the European Regional Development Funds, and the Government of Extremadura (Department of Education, Science, and Vocational Training)./ PT - Journal Article DEP - 20251117 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC12649518 OTO - NOTNLM OT - alternative invasion sport OT - basic psychological needs OT - gender OT - intention to do physical exercise OT - pedagogical models OT - physical education COIS- The authors declare that there are no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/11/27 06:29 MHDA- 2025/11/27 06:30 PMCR- 2025/11/17 CRDT- 2025/11/27 01:06 PHST- 2025/09/19 00:00 [received] PHST- 2025/10/28 00:00 [revised] PHST- 2025/11/13 00:00 [accepted] PHST- 2025/11/27 06:30 [medline] PHST- 2025/11/27 06:29 [pubmed] PHST- 2025/11/27 01:06 [entrez] PHST- 2025/11/17 00:00 [pmc-release] AID - bs15111574 [pii] AID - behavsci-15-01574 [pii] AID - 10.3390/bs15111574 [doi] PST - epublish SO - Behav Sci (Basel). 2025 Nov 17;15(11):1574. doi: 10.3390/bs15111574. PMID- 41301337 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251127 LR - 20251130 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 15 IP - 11 DP - 2025 Nov 11 TI - Problematic Internet Use in Adolescents Is Driven by Internal Distress Rather Than Family or Socioeconomic Contexts: Evidence from South Tyrol, Italy. LID - 10.3390/bs15111534 [doi] LID - 1534 AB - Problematic Internet use is an emerging concern in adolescent mental health and is closely linked to psychological distress and emotional regulation. This cross-sectional study analyzed self-reported data from 1550 adolescents aged 11-19 years in South Tyrol, a linguistically and culturally diverse region in Northern Italy. Problematic Internet use was measured using the validated Generalized Problematic Internet Use Scale 2 (GPIUS-2), along with standardized instruments for depressive symptoms (PHQ-2) and anxiety (SCARED-GAD). Multivariable regression analysis revealed that depression and anxiety symptoms were the strongest independent predictors of higher GPIUS-2 scores. In contrast, demographic factors such as gender, family language, urbanization, migration background, and parental education were not significantly associated with PIU. Modest associations were observed between GPIUS-2 scores and both perceived economic burden and parental use of digital control tools. Perceived family support showed a small protective effect. These findings underscore the central role of emotional vulnerability in adolescent PIU and suggest that interventions should focus on supporting mental health and adaptive coping rather than solely targeting screen time or structural family characteristics. FAU - Wiedermann, Christian J AU - Wiedermann CJ AUID- ORCID: 0000-0002-4639-8195 AD - Institute of General Practice and Public Health, Claudiana College of Health Professions, 39100 Bolzano, Italy. FAU - Barbieri, Verena AU - Barbieri V AUID- ORCID: 0000-0002-5934-9472 AD - Institute of General Practice and Public Health, Claudiana College of Health Professions, 39100 Bolzano, Italy. FAU - Piccoliori, Giuliano AU - Piccoliori G AUID- ORCID: 0000-0003-1974-4184 AD - Institute of General Practice and Public Health, Claudiana College of Health Professions, 39100 Bolzano, Italy. FAU - Engl, Adolf AU - Engl A AUID- ORCID: 0009-0007-2720-001X AD - Institute of General Practice and Public Health, Claudiana College of Health Professions, 39100 Bolzano, Italy. LA - eng PT - Journal Article DEP - 20251111 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC12649401 OTO - NOTNLM OT - South Tyrol OT - adolescents OT - cross-sectional survey OT - digital behavior OT - emotional regulation OT - mental health OT - problematic Internet use OT - psychological distress COIS- The authors declare no conflicts of interest. EDAT- 2025/11/27 06:28 MHDA- 2025/11/27 06:29 PMCR- 2025/11/11 CRDT- 2025/11/27 01:06 PHST- 2025/09/11 00:00 [received] PHST- 2025/11/05 00:00 [revised] PHST- 2025/11/10 00:00 [accepted] PHST- 2025/11/27 06:29 [medline] PHST- 2025/11/27 06:28 [pubmed] PHST- 2025/11/27 01:06 [entrez] PHST- 2025/11/11 00:00 [pmc-release] AID - bs15111534 [pii] AID - behavsci-15-01534 [pii] AID - 10.3390/bs15111534 [doi] PST - epublish SO - Behav Sci (Basel). 2025 Nov 11;15(11):1534. doi: 10.3390/bs15111534. PMID- 41300682 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251127 LR - 20251130 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 11 DP - 2025 Nov 18 TI - Role of Matsuda Index in Identifying Patients at Risk for Cystic Fibrosis-Related Diabetes Development. LID - 10.3390/children12111566 [doi] LID - 1566 AB - Background: Cystic fibrosis-related diabetes (CFRD) is a frequent comorbidity in individuals with cystic fibrosis (CF). While insulin secretion defects are the primary mechanism in CFRD pathophysiology, insulin resistance may contribute as an additional risk factor. Early detection of insulin resistance may help identify patients at higher risk for earlier CFRD development. Objective: The aim of this study was to evaluate the ability of the Matsuda Index to identify insulin resistance in pediatric CF patients and to compare it with HOMA-IR as complementary indicators of glucose metabolism. Methods: In this cross-sectional study, fifty children with CF aged 6-16 years were included. The study involved measuring anthropometric data, fasting insulin, fasting glucose levels, glycated hemoglobin (HbA1c), and C-peptide. An assessment of glucose and insulin levels was performed on the patients through an oral glucose tolerance test (OGTT) at 0, 60, and 120 min. The Matsuda Index was computed, wherein a threshold of /= 0.70. These minimum-day estimates were validated using the second 14-day period, drawing random sets of consecutive and non-consecutive days. RESULTS: ICCs in the first period ranged from 0.80-0.97. Required days for acceptable reliability varied by FPP construct: Coercive control (1 day); Autonomy support, Child involvement, and Meal routines (5-6 days); and Rules and limits, Nondirective support, and Healthy opportunities (8-9 days). Compared to fathers, mothers required fewer days to reliably assess Rules and Limits, Healthy Opportunities, Autonomy and Nondirective Support. Validation in the second period showed ICCs >/= 0.70 except for Healthy opportunities, Nondirective support, and Child involvement, which had borderline ICCs (0.63-0.68) in some subgroups and sampling approaches. CONCLUSIONS: This study provides a valid and reliable instrument to measure FPP in Daily Diary protocols. Although 14 days of data collection ensures high reliability, many FPP constructs can be assessed reliably with fewer days. To reduce participant burden, researchers may tailor diary duration based on the specific construct and caregiver sex. FAU - De-Jongh Gonzalez, Olivia AU - De-Jongh Gonzalez O AUID- ORCID: 0000-0003-4782-9513 AD - School of Population and Public Health, University of British Columbia, BC Children's Hospital Research Institute, F609-4480 Oak Street, Vancouver, BC, V5Z 4H4, Canada. FAU - Masse, Louise C AU - Masse LC AUID- ORCID: 0000-0003-2483-8791 AD - School of Population and Public Health, University of British Columbia, BC Children's Hospital Research Institute, F605B-4490 Oak Street, Vancouver, BC, V5Z 4H4, Canada. lmasse@bcchr.ubc.ca. LA - eng PT - Journal Article PT - Validation Study DEP - 20251126 PL - England TA - Int J Behav Nutr Phys Act JT - The international journal of behavioral nutrition and physical activity JID - 101217089 SB - IM MH - Humans MH - *Parenting MH - Reproducibility of Results MH - Male MH - Child, Preschool MH - Female MH - Adult MH - Child MH - *Feeding Behavior MH - Longitudinal Studies MH - Mothers MH - Surveys and Questionnaires PMC - PMC12752353 OTO - NOTNLM OT - Daily diary OT - Fathers OT - Food parenting practices OT - Intensive longitudinal methods OT - Measurement OT - Mothers OT - Reliability OT - Validity COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Research Ethics Board of the University of British Columbia (H18-01434) as part of the GSM Parenting Project, and all participants signed an informed consent, either in paper or online, before participating in this study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/27 06:28 MHDA- 2026/06/27 04:09 PMCR- 2025/11/26 CRDT- 2025/11/27 00:14 PHST- 2025/06/30 00:00 [received] PHST- 2025/10/27 00:00 [accepted] PHST- 2026/06/27 04:09 [medline] PHST- 2025/11/27 06:28 [pubmed] PHST- 2025/11/27 00:14 [entrez] PHST- 2025/11/26 00:00 [pmc-release] AID - 10.1186/s12966-025-01855-z [pii] AID - 1855 [pii] AID - 10.1186/s12966-025-01855-z [doi] PST - epublish SO - Int J Behav Nutr Phys Act. 2025 Nov 26;22(1):162. doi: 10.1186/s12966-025-01855-z. PMID- 41298618 OWN - NLM STAT- MEDLINE DCOM- 20251126 LR - 20261017 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Nov 26 TI - Comparative survey of eating and lifestyle habits in Italian school age children using Nutripiatto as an educational tool. PG - 42234 LID - 10.1038/s41598-025-26302-8 [doi] LID - 42234 AB - Nutripiatto, a Mediterranean diet - based educational tool combining a colorful plate and recipe guide, was evaluated in 781 children (6-10 years) from Lazio, Piedmont, and Sicily, divided in age related-groups (A and B). Eating habits were assessed at baseline (T0) and after 2 months (T1) using a non-validate caregiver completed FFQ; 525 children (67%) completed both assessments. At T1, children showed greater awareness of portion sizes and food frequencies. In Group A, portion size awareness improved in Sicily (vegetable drinks, whole grain cereals) and Piedmont (cereals, yogurt, potatoes, meat). In both regions, children also increased their frequency of consumption of vegetables and fruit, while reducing red pizza, cold cuts, and meat in Piedmont, and French fries, crisps and cold cuts in Sicily. In Lazio, children increased their intake of crackers and fish while reducing French fries. In Group B, children in Piedmont increased the consumption of vegetables and fruit, in Lazio nuts while in Sicily they reduced crisps. Across both groups, water intake increased in Lazio and Sicily. Overall, regional dietary patterns persisted, characterized by higher processed and protein-rich foods (Lazio), greater bread and water intake (Sicily), and higher fruit and vegetable consumption (Piedmont). Despite the short duration and reliance on caregiver reports, Nutripiatto may appear to be a feasible, engaging school-based tool supporting healthier eating, warranting larger controlled studies. CI - (c) 2025. The Author(s). FAU - Spiezia, Chiara AU - Spiezia C AD - Research Unit of Food Science and Human Nutrition, Department of Science and Technology for Sustainable Development and One Health, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128, Roma, Italy. chiara.spiezia@unicampus.it. FAU - Di Rosa, Claudia AU - Di Rosa C AD - Research Unit of Food Science and Human Nutrition, Department of Science and Technology for Sustainable Development and One Health, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128, Roma, Italy. FAU - Monticone, Martina AU - Monticone M AD - Research Unit of Food Science and Human Nutrition, Department of Science and Technology for Sustainable Development and One Health, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128, Roma, Italy. FAU - Lattanzi, Greta AU - Lattanzi G AD - Research Unit of Food Science and Human Nutrition, Department of Science and Technology for Sustainable Development and One Health, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128, Roma, Italy. FAU - La Farina, Francesca AU - La Farina F AD - Medical Consultation and Guidance Hub - LUISS Guido Carli University, Rome, Italy. FAU - De Gara, Laura AU - De Gara L AD - Research Unit of Food Science and Human Nutrition, Department of Science and Technology for Sustainable Development and One Health, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128, Roma, Italy. FAU - Khazrai, Yeganeh Manon AU - Khazrai YM AD - Research Unit of Food Science and Human Nutrition, Department of Science and Technology for Sustainable Development and One Health, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128, Roma, Italy. LA - eng PT - Comparative Study PT - Journal Article DEP - 20251126 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - *Feeding Behavior MH - Italy MH - *Life Style MH - *Diet, Mediterranean MH - Surveys and Questionnaires MH - Vegetables MH - Sicily PMC - PMC12658186 OTO - NOTNLM OT - Childhood obesity OT - Food frequency questionnaire (FFQ) OT - Nutripiatto OT - Nutritional education tools OT - Paediatric dietary habits OT - Regional nutritional differences COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/11/27 00:27 MHDA- 2025/11/27 00:28 PMCR- 2025/11/26 CRDT- 2025/11/26 23:31 PHST- 2024/12/14 00:00 [received] PHST- 2025/10/28 00:00 [accepted] PHST- 2025/11/27 00:28 [medline] PHST- 2025/11/27 00:27 [pubmed] PHST- 2025/11/26 23:31 [entrez] PHST- 2025/11/26 00:00 [pmc-release] AID - 10.1038/s41598-025-26302-8 [pii] AID - 26302 [pii] AID - 10.1038/s41598-025-26302-8 [doi] PST - epublish SO - Sci Rep. 2025 Nov 26;15(1):42234. doi: 10.1038/s41598-025-26302-8. PMID- 41298483 OWN - NLM STAT- MEDLINE DCOM- 20251126 LR - 20261019 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Nov 26 TI - Comparison of the reliability of ANB Sar and W measurements used in cephalometric diagnostics for the assessment of sagittal discrepancy. PG - 42072 LID - 10.1038/s41598-025-25968-4 [doi] LID - 42072 AB - Accurate cephalometric assessment is used in orthodontic diagnosis and treatment planning. The aim of this study was to confirm the reliability of Sar and W angle measurements with the results obtained for the ANB angle. The reliability of angular measurements for determining sagittal discrepancy was assessed after determining anthropometric points (N, A, B, S, W, M, G). These formed the ANB, Sar, and W angles, respectively. Cephalometric analyses were performed separately, 7 days apart, by 22 orthodontists. To determine inter-rater reliability, a two-way ANOVA without repeated measures was used, using the ICC(3,1) coefficient. To compare the reliability of the ANB, Sar, and W angles, the Blant-Altman plot, Dahlberg formula, intraclass correlation coefficients (ICC), R2 coefficients, and R&R coefficients were used. Pearson's chi-square test was used to assess the number of individuals classified into each skeletal class. The ICC(3.1) coefficient at a 95% confidence level was 0.941 for the ANB angle, 0.679 for the Sar angle, and 0.688 for the W angle. These results demonstrate excellent measurement reliability for the ANB angle and good reliability for the Sar and W angles. The participating orthodontists measured sagittal discrepancy significantly more accurately using the ANB angle compared to the Sar and W angles. One of the main factors implying poorer reliability of the Sar and W results is operator error. The difficulty in determining the values of the angle tests is related to the determination of new anthropometric points. The obtained results indicate higher reliability of the ANB measurement in assessing sagittal discrepancy in malocclusions. The Sar and W angles can be used to a limited extent, especially in the assessment of extreme cases. Further studies determining the usefulness of the new Sar and W angles in the orthodontic diagnosis of sagittal discrepancy should be correlated with previous measurements, including Wits or Beta angle measurements. CI - (c) 2025. The Author(s). FAU - Kotula, Jacek AU - Kotula J AD - Department of Dentofacial Orthopedics and Orthodontics, Wroclaw Medical University, Krakowska 26, Wroclaw, 50-425, Poland. j_kotula@poczta.onet.pl. FAU - Kotula, Krzysztof AU - Kotula K AD - Faculty of Medicine, Pomeranian Medical University, Szczecin, Poland. FAU - Szelag, Ewa AU - Szelag E AD - Department of Dentofacial Orthopedics and Orthodontics, Wroclaw Medical University, Krakowska 26, Wroclaw, 50-425, Poland. FAU - Kotarska, Malgorzata AU - Kotarska M AD - Department of Integrated Dentistry, Wroclaw Medical University, Krakowska 26, Wroclaw, 50-425, Poland. FAU - Lis, Joanna AU - Lis J AD - Department of Dentofacial Orthopedics and Orthodontics, Wroclaw Medical University, Krakowska 26, Wroclaw, 50-425, Poland. FAU - Kawala, Beata AU - Kawala B AD - Department of Dentofacial Orthopedics and Orthodontics, Wroclaw Medical University, Krakowska 26, Wroclaw, 50-425, Poland. FAU - Sarul, Michal AU - Sarul M AD - Department of Integrated Dentistry, Wroclaw Medical University, Krakowska 26, Wroclaw, 50-425, Poland. FAU - Kuc, Anna Ewa AU - Kuc AE AD - Department of Dentofacial Orthopedics and Orthodontics, Wroclaw Medical University, Krakowska 26, Wroclaw, 50-425, Poland. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251126 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Cephalometry/methods MH - Reproducibility of Results MH - Male MH - Female MH - Adolescent MH - *Malocclusion/diagnosis MH - Adult PMC - PMC12658264 OTO - NOTNLM OT - Algorithms OT - Cephalometry/statistics and numerical data OT - Eproducibility of results COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: The study was conducted in accordance with the Declaration of Helsinki and was approved by the Bioethics Committee of the District Medical Chamber in Zielona Gora (decision 01/173/2023 of March 6, 2023). Consent to participate: All patients signed informed consent before entering the study. Informed consent: of the patient to participate in the research. All those who received information about the results of the research, about their impact on the patient's health, about the possibility of occurring immediately after the start of the research and signed conscious consent to participate in the research. EDAT- 2025/11/27 00:27 MHDA- 2025/11/27 00:28 PMCR- 2025/11/26 CRDT- 2025/11/26 23:20 PHST- 2025/04/21 00:00 [received] PHST- 2025/10/27 00:00 [accepted] PHST- 2025/11/27 00:28 [medline] PHST- 2025/11/27 00:27 [pubmed] PHST- 2025/11/26 23:20 [entrez] PHST- 2025/11/26 00:00 [pmc-release] AID - 10.1038/s41598-025-25968-4 [pii] AID - 25968 [pii] AID - 10.1038/s41598-025-25968-4 [doi] PST - epublish SO - Sci Rep. 2025 Nov 26;15(1):42072. doi: 10.1038/s41598-025-25968-4. PMID- 41298448 OWN - NLM STAT- MEDLINE DCOM- 20251126 LR - 20251129 IS - 2055-1010 (Electronic) IS - 2055-1010 (Linking) VI - 35 IP - 1 DP - 2025 Nov 26 TI - Characterizing adult asthma: a cross-sectional epidemiologic study from the canadian primary care sentinel surveillance network. PG - 57 LID - 10.1038/s41533-025-00461-7 [doi] LID - 57 AB - National asthma prevalence data in Canada typically come from health surveys or administrative records. Since most asthma care is provided by family physicians, primary care electronic medical records (EMRs) may offer valuable insights into asthma epidemiology and treatment patterns. This study aimed to estimate the prevalence of adult asthma across Canada using national EMR data, examine the demographics and comorbidities of asthma patients, and review national prescribing practices. We used a validated EMR case definition for adult asthma applied to the Canadian Primary Care Sentinel Surveillance Network (CPCSSN) database, which includes data from 12 networks across Canada. We identified patients with at least one encounter in a two-year period and estimated asthma prevalence, stratified by age, sex, and BMI. Comorbidity rates and medication prescriptions were assessed in patients with asthma. Among 854,567 adults, 94,410 were identified with confirmed/suspected asthma (11% prevalence). Asthma was more common in females (12 vs. 10%, p < 0.0001), across all age brackets except 18-29 years old. A chi-square test for trend showed a decrease in prevalence with increasing age (p < 0.0001). Females with asthma had a higher prevalence of >/=4 comorbidities than males (33 vs. 30%, p < 0.0001). Additionally, 13% of asthma patients were prescribed only as-needed short-acting bronchodilators, without a controller. The 11% asthma prevalence found in this study aligns with national survey estimates, providing support for the use of EMRs in disease and practice surveillance. Future efforts should focus on integrating tools within EMR to support asthma diagnosis and treatment adherence. CI - (c) 2025. The Author(s). FAU - Allarakhia, Sabrina AU - Allarakhia S AD - Kingston Health Sciences Centre, Kingston, ON, Canada. sabrina.allarakhia@mail.utoronto.ca. AD - Division of Respirology, Department of Medicine, St. Michael's Hospital, Toronto, Ontario, Canada. sabrina.allarakhia@mail.utoronto.ca. FAU - Morra, Alison AU - Morra A AD - Asthma Research Unit, Kingston General Hospital, 72 Stuart Street, Kingston, Ontario, Canada. AD - Division of Respirology, Department of Medicine, Queen's University, Kingston, Ontario, Canada. FAU - Theal, Rebecca AU - Theal R AD - Canadian Primary Care Sentinel Surveillance Network (Eastern Ontario Network), Kingston, Ontario, Canada. FAU - Moloney, Max AU - Moloney M AD - Asthma Research Unit, Kingston General Hospital, 72 Stuart Street, Kingston, Ontario, Canada. FAU - Gupta, Samir AU - Gupta S AD - Division of Respirology, Department of Medicine, St. Michael's Hospital, Toronto, Ontario, Canada. AD - Li Ka Shing Knowledge Institute, University of Toronto, Toronto, Ontario, Canada. FAU - To, Teresa AU - To T AD - Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada. AD - Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. FAU - Digby, Genevieve AU - Digby G AD - Division of Respirology, Department of Medicine, Queen's University, Kingston, Ontario, Canada. FAU - Barber, David AU - Barber D AD - Canadian Primary Care Sentinel Surveillance Network (Eastern Ontario Network), Kingston, Ontario, Canada. AD - Department of Family Medicine, Queen's University, Kingston, Ontario, Canada. FAU - Queenan, John AU - Queenan J AD - Canadian Primary Care Sentinel Surveillance Network (Eastern Ontario Network), Kingston, Ontario, Canada. FAU - Lougheed, M Diane AU - Lougheed MD AD - Kingston Health Sciences Centre, Kingston, ON, Canada. AD - Asthma Research Unit, Kingston General Hospital, 72 Stuart Street, Kingston, Ontario, Canada. AD - Division of Respirology, Department of Medicine, Queen's University, Kingston, Ontario, Canada. AD - Department of Public Health Sciences, Queen's University, Kingston, Ontario, Canada. LA - eng PT - Journal Article DEP - 20251126 PL - England TA - NPJ Prim Care Respir Med JT - NPJ primary care respiratory medicine JID - 101631999 SB - IM MH - Humans MH - *Asthma/epidemiology/drug therapy MH - Male MH - Female MH - Adult MH - Canada/epidemiology MH - Middle Aged MH - Sentinel Surveillance MH - Cross-Sectional Studies MH - *Primary Health Care MH - Prevalence MH - Adolescent MH - Young Adult MH - Aged MH - Comorbidity MH - Electronic Health Records PMC - PMC12658228 COIS- Competing interests: In the past 3 years, M. Diane Lougheed has received grants outside the submitted work paid directly to Queen's University from the Canadian Institutes of Health Research (sub-grants from Ottawa Health Research Institute and University of Toronto), Manitoba Workers Compensation Board, Astra Zeneca and GlaxoSmithKline; and an honorarium from AstraZeneca for participation in the Precision Program Advisory Board. She has also served as a member of Health Quality Ontario's Asthma in Adults and Asthma in Children Quality Standard Advisory Committees. A. Morra has received honoraria for participation in a PRECISION Severe Asthma Summit Meeting from Astra Zeneca. G. Digby has received research funding from MaRS/Merck & Co Inc and from Pfizer Inc, as well as an honorarium from Merck & Co Inc for a speaking engagement and from AstraZeneca for participation in a working group. She has also received grants outside the submitted work paid directly to Queen's University from the Ontario Lung Association and Ontario Thoracic Society. She serves as the Canadian Thoracic Society Choosing Wisely Canada Working Group chair. EDAT- 2025/11/27 00:27 MHDA- 2025/11/27 00:28 PMCR- 2025/11/26 CRDT- 2025/11/26 23:18 PHST- 2024/12/14 00:00 [received] PHST- 2025/10/20 00:00 [accepted] PHST- 2025/11/27 00:28 [medline] PHST- 2025/11/27 00:27 [pubmed] PHST- 2025/11/26 23:18 [entrez] PHST- 2025/11/26 00:00 [pmc-release] AID - 10.1038/s41533-025-00461-7 [pii] AID - 461 [pii] AID - 10.1038/s41533-025-00461-7 [doi] PST - epublish SO - NPJ Prim Care Respir Med. 2025 Nov 26;35(1):57. doi: 10.1038/s41533-025-00461-7. PMID- 41296763 OWN - NLM STAT- MEDLINE DCOM- 20251126 LR - 20251129 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 11 DP - 2025 TI - Understanding real and mythical cancer risk factors: Insights from a university-based study. PG - e0336102 LID - 10.1371/journal.pone.0336102 [doi] LID - e0336102 AB - Despite extensive research on cancer etiology, many cancers remain associated with preventable risk factors. Raising public awareness of these factors is critical for promoting preventive behaviors. This study aimed to assess university students' awareness of both scientifically validated and mythical cancer causes, to identify sociodemographic and health/lifestyle-related factors associated with awareness levels, and to examine the relationship between awareness of evidence-based and mythical cancer risk factors. A cross-sectional survey was conducted among 896 students from three Universities in Turkey. Data were collected using a Personal Information Form, the Cancer Awareness Measure (CAM) and Cancer Awareness Measure - Mythical Causes Scale (CAM-MYCS), which evaluates belief in widely held but scientifically unsubstantiated cancer causes (e.g., microwave ovens, stress, artificial sweeteners, electromagnetic frequencies). Statistical analyses included descriptive statistics, Spearman's correlation, and multiple linear regression. Participants demonstrated significantly higher awareness of scientifically established cancer causes (70.7%) compared to mythical ones (10.2%). A moderate negative correlation was observed between CAM and CAM-MYCS scores (r = -0.511; p < 0.001), indicating that increased awareness of real causes is associated with decreased belief in myths. Regression analysis revealed that CAM scores were significantly predicted by academic year, being in the normal Body Mass Index (BMI) spectrum, and by having attended an oncology course (R(2) = 0.142; p < 0.001), whereas CAM-MYCS scores were predicted by academic year and high BMI values (R(2) = 0.072; p < 0.001). These findings highlight the need for targeted educational interventions aimed at both enhancing awareness of factual cancer risk factors and correcting persistent misconceptions. The results provide valuable insights for university-based public health initiatives seeking to improve cancer literacy and promote preventive health and lifestyle behaviors among young adults. CI - Copyright: (c) 2025 Yildirim-Kahriman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Yildirim-Kahriman, Senay AU - Yildirim-Kahriman S AD - Faculty of Health Sciences, Demiroglu Bilim University, Istanbul, Turkey. FAU - Yildirim, Gulay AU - Yildirim G AUID- ORCID: 0000-0003-1164-3274 AD - Department of Nursing, Kesan Hakki Yoruk School of Health, Trakya University, Edirne, Turkey. FAU - Kose, Selmin AU - Kose S AD - Department of Nursing, Faculty of Health Sciences, Biruni University, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20251126 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - Male MH - *Neoplasms/etiology/epidemiology/prevention & control MH - Universities MH - Risk Factors MH - Young Adult MH - Adult MH - *Health Knowledge, Attitudes, Practice MH - Cross-Sectional Studies MH - Students/psychology MH - Turkey MH - Surveys and Questionnaires MH - Adolescent PMC - PMC12654919 COIS- The authors have declared that no competing interests exist. EDAT- 2025/11/26 18:27 MHDA- 2025/11/26 18:28 PMCR- 2025/11/26 CRDT- 2025/11/26 13:34 PHST- 2025/04/26 00:00 [received] PHST- 2025/10/30 00:00 [accepted] PHST- 2025/11/26 18:28 [medline] PHST- 2025/11/26 18:27 [pubmed] PHST- 2025/11/26 13:34 [entrez] PHST- 2025/11/26 00:00 [pmc-release] AID - PONE-D-25-18299 [pii] AID - 10.1371/journal.pone.0336102 [doi] PST - epublish SO - PLoS One. 2025 Nov 26;20(11):e0336102. doi: 10.1371/journal.pone.0336102. eCollection 2025. PMID- 41296283 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260906 IS - 2194-1327 (Electronic) IS - 0948-6259 (Print) IS - 0948-6259 (Linking) VI - 40 IP - 3 DP - 2026 Sep TI - Patients with anorexia nervosa perceive higher emotional connectedness to their parents than bulimia nervosa patients independent of objective family factors. PG - 113-119 LID - 10.1007/s40211-025-00558-y [doi] AB - BACKGROUND: Psychological constructs of individual autonomy (IA) and emotional connectedness (EC) differ between patients with anorexia nervosa (AN) and bulimia nervosa (BN); however, it is unclear whether objective family factors modulate these associations. METHODS: In a cohort of 445 participants from the FamFINED study (FAMily Factors INvolved in Eating Disorders) with eating disorders (EDs) diagnosed as AN (n = 232) or BN (n = 213), we assessed objective psychosocial family factors as well as the IA and EC constructs using the self-rated Subjective Family Image Test (SFIT) questionnaire. RESULTS: While the two ED entities did not differ with respect to IA in univariate analysis (p = 0.355), patients diagnosed with AN had higher perceived EC than participants with BN, as assessed by a lower score for the difference between the actual and desired family image (16.0 +/- 15.8 vs. 21.6 +/- 17.6, p < 0.001). In a regression model adjusted for age, body-mass index, living in parental home, and parental separation, we found that the EC score used as the dependent variable differed significantly between the two ED entities (expbeta = 4.8, 95% confidence interval = 0.54-9.11, p = 0.028). In contrast, no association was observed between IA and ED diagnoses using the same set of confounders (p = 0.717). CONCLUSION: The higher perceived EC in AN patients compared to those diagnosed with BN indicates more intense feelings of family solidarity, regardless of objective family factors. CI - (c) 2025. The Author(s). FAU - Fischer, Elias AU - Fischer E AD - Department of Psychosomatic Medicine and Psychotherapy, University of Gottingen, Von-Siebold-Str. 5, Gottingen, Germany. FAU - Lensch, Noah AU - Lensch N AD - Department of Psychosomatic Medicine and Psychotherapy, University of Gottingen, Von-Siebold-Str. 5, Gottingen, Germany. FAU - Reich, Gunter AU - Reich G AD - Department of Psychosomatic Medicine and Psychotherapy, University of Gottingen, Von-Siebold-Str. 5, Gottingen, Germany. FAU - Meyer, Thomas AU - Meyer T AUID- ORCID: 0000-0003-3509-1400 AD - Department of Psychosomatic Medicine and Psychotherapy, University of Gottingen, Von-Siebold-Str. 5, Gottingen, Germany. thomas.meyer@med.uni-goettingen.de. LA - eng PT - Comparative Study PT - Journal Article TT - Patientinnen mit Anorexia nervosa empfinden eine starkere emotionale Bindung zu ihren Eltern als Patienten mit Bulimia nervosa, unabhangig von objektiven familiaren Faktoren. DEP - 20251126 PL - Germany TA - Neuropsychiatr JT - Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater JID - 9440588 SB - IM MH - Humans MH - *Anorexia Nervosa/psychology/diagnosis MH - *Bulimia Nervosa/psychology/diagnosis MH - Female MH - Adult MH - *Emotions MH - Adolescent MH - Young Adult MH - Personal Autonomy MH - Male MH - *Parent-Child Relations MH - Cohort Studies MH - Surveys and Questionnaires MH - Psychometrics PMC - PMC13541804 OTO - NOTNLM OT - Eating disorders OT - Emotional connectedness OT - Family perception OT - Individual autonomy OT - Subjective Family Image Test COIS- Declarations. Conflict of interest: E. Fischer, N. Lensch, G. Reich and T. Meyer declare that they have no competing interests. Ethical standards: Ethical approval (#32/1/17) for the study was obtained from the Institutional Review Board of the University of Gottingen Medical Center, and the trial was registered in the ClinicalTrials.gov register (#NCT05339165). EDAT- 2025/11/26 13:11 MHDA- 2026/09/03 17:36 PMCR- 2025/11/26 CRDT- 2025/11/26 11:22 PHST- 2025/08/04 00:00 [received] PHST- 2025/10/30 00:00 [accepted] PHST- 2026/09/03 17:36 [medline] PHST- 2025/11/26 13:11 [pubmed] PHST- 2025/11/26 11:22 [entrez] PHST- 2025/11/26 00:00 [pmc-release] AID - 10.1007/s40211-025-00558-y [pii] AID - 558 [pii] AID - 10.1007/s40211-025-00558-y [doi] PST - ppublish SO - Neuropsychiatr. 2026 Sep;40(3):113-119. doi: 10.1007/s40211-025-00558-y. Epub 2025 Nov 26. PMID- 41295895 OWN - NLM STAT- MEDLINE DCOM- 20260811 LR - 20260811 IS - 1545-1569 (Electronic) IS - 1055-6656 (Linking) VI - 63 IP - 9 DP - 2026 Sep TI - A Novel Bilateral Cleft Lip Severity Index: Correlation With Long-Term Outcomes. PG - 2877-2885 LID - 10.1177/10556656251399648 [doi] AB - ObjectiveBilateral cleft lip outcomes are heavily influenced by original anatomic deformity, but a reliable and widely accepted classification of preoperative severity has yet to emerge. This study validates the Bilateral Cleft Lip Severity Index (BCLSI) by assessing interrater reliability and the relationship between preoperative severity and aesthetic outcomes.DesignRetrospective cohort study.SettingTertiary care pediatric hospital.Patients/ParticipantsPatients who underwent lip repair for bilateral cleft lip.InterventionsCleft surgeons and layperson raters graded preoperative cleft severity.Main Outcome Measure(s)Anthropometric analyses and crowdsourced aesthetic assessments using Likert scales and pairwise comparisons.ResultsIntraclass correlation coefficient was 0.94 (95% confidence interval [CI] 0.90-0.97) among cleft surgeon raters (n = 7), 0.84 (95% CI 0.73-0.92) among layperson raters (n = 10), and 0.88 (95% CI 0.80-0.94) in the combined group (n = 17). Among 18 patients, a higher BCLSI correlated with a greater columellar-labial angle (r = 0.686, P = .002). BCLSI predicted pairwise rank-derived coefficients (beta = -1.289, P = .015), lateral ratings (beta = 0.752, P < .001), frontal ratings (beta = 0.440, P = .038), and composite ratings (beta = 0.551, P = .006) independent of age at surgery, age at postoperative photograph, history of nasoalveolar molding, lip repair technique, sex, and race. A greater columellar-labial angle correlated with poor lateral (r = .729, P < .001) and composite (r = .471, P = .048) ratings.ConclusionsThe BCLSI demonstrates good interrater reliability among cleft surgeons and layperson raters. A higher BCLSI correlated with a greater columellar-labial angle and predicted poorer nasal appearance ratings by crowdsourced layperson assessments at 5 years postoperatively. The BCLSI is a simple, reliable, and informative tool that can standardize bilateral cleft lip classification and advance cleft outcomes research. FAU - Ng, Jinggang J AU - Ng JJ AUID- ORCID: 0000-0002-1180-7526 AD - Division of Plastic, Reconstructive, and Oral Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA. RINGGOLD: 6567 FAU - Banala, Manisha AU - Banala M AD - Division of Plastic, Reconstructive, and Oral Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA. RINGGOLD: 6567 FAU - Massenburg, Benjamin Ballard AU - Massenburg BB AUID- ORCID: 0000-0002-8570-5178 AD - Division of Plastic, Reconstructive, and Oral Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA. RINGGOLD: 6567 FAU - Sussman, Jonathan H AU - Sussman JH AD - Division of Plastic, Reconstructive, and Oral Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA. RINGGOLD: 6567 FAU - Wu, Meagan AU - Wu M AD - Division of Plastic, Reconstructive, and Oral Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA. RINGGOLD: 6567 FAU - Romeo, Dominic J AU - Romeo DJ AUID- ORCID: 0000-0003-0150-4174 AD - Division of Plastic, Reconstructive, and Oral Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA. RINGGOLD: 6567 FAU - Bartlett, Scott P AU - Bartlett SP AD - Division of Plastic, Reconstructive, and Oral Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA. RINGGOLD: 6567 FAU - Low, David W AU - Low DW AUID- ORCID: 0000-0002-7995-7256 AD - Division of Plastic, Reconstructive, and Oral Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA. RINGGOLD: 6567 FAU - Swanson, Jordan W AU - Swanson JW AUID- ORCID: 0000-0001-7112-8114 AD - Division of Plastic, Reconstructive, and Oral Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA. RINGGOLD: 6567 FAU - Taylor, Jesse A AU - Taylor JA AUID- ORCID: 0000-0003-2827-5471 AD - Division of Plastic, Reconstructive, and Oral Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA. RINGGOLD: 6567 LA - eng PT - Journal Article DEP - 20251126 PL - United States TA - Cleft Palate Craniofac J JT - The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association JID - 9102566 SB - IM MH - Humans MH - *Cleft Lip/surgery/classification/pathology MH - Female MH - Severity of Illness Index MH - Treatment Outcome MH - Reproducibility of Results MH - Male MH - Esthetics MH - Infant MH - Child, Preschool MH - Plastic Surgery Procedures MH - Observer Variation MH - Cohort Studies OTO - NOTNLM OT - bilateral OT - cleft lip OT - cleft lip and palate OT - lip repair OT - nasal morphology COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/11/26 13:12 MHDA- 2026/08/11 12:37 CRDT- 2025/11/26 10:13 PHST- 2026/08/11 12:37 [medline] PHST- 2025/11/26 13:12 [pubmed] PHST- 2025/11/26 10:13 [entrez] AID - 10.1177/10556656251399648 [doi] PST - ppublish SO - Cleft Palate Craniofac J. 2026 Sep;63(9):2877-2885. doi: 10.1177/10556656251399648. Epub 2025 Nov 26. PMID- 41295091 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251126 LR - 20251129 IS - 2313-433X (Electronic) IS - 2313-433X (Linking) VI - 11 IP - 11 DP - 2025 Oct 25 TI - A Comprehensive Evaluation of Thigh Mineral-Free Lean Mass Measures Using Dual Energy X-Ray Absorptiometry (DXA) in Young Children. LID - 10.3390/jimaging11110374 [doi] LID - 374 AB - This study aimed to (1) demonstrate the intra- and interrater reliability of quadriceps (QUADS) and hamstring (HAMS) mineral-free lean (MFL) mass measures using DXA scanning, (2) determine the association of total thigh MFL mass measures with MFL mass measures of the hamstrings and quadriceps combined and (3) analyze the association between total thigh MFL mass and total body MFL mass measures. A total of 80 young children (aged 5 to 11 yrs) participated and unique regions of interest were created using custom analysis software with manual tracing of the QUADS, HAMS, and total thigh MFL mass measures. Repeated-measure analysis of variance was used to determine if there were significant differences among the MFL measures while intraclass correlation coefficients (ICC), coefficients of variation (CV), and regression analysis were used to determine the intra- and interrater reliability and the explained variance in the association among MFL mass measures. The right interrater QUADS MFL mass was the only significant group mean difference, and ICCs between (>/=0.961) and within (>/=0.919) raters were high for all MFL measures with low variation across all MFL measures ( 3 mm (OR = 0.509) as protective factors (all P < 0.05). SHAP interpretation indicated that operation time (+ 0.075) and history of abdominal surgery (+ 0.059) were the primary contributors to POPF prediction. RCS analysis highlighted BMI exceeding 24 kg/m(2) and operation time exceeding 200 min as key thresholds for increased POPF risk. The nomogram demonstrated AUC values of 0.761 (95% CI: 0.697-0.825) in the training cohort and 0.814 (95% CI: 0.702-0.927) in the validation cohort. The HL test yielded P = 0.615 and P = 0.410, respectively, indicating good calibration. DCA showed high net benefit in the training cohort at threshold probabilities of approximately 12%-91% and in the validation cohort at 15%-98%. Compared with CAR, NLR, and PLR, the nomogram exhibited superior AUC (0.761 vs. 0.621, 0.662, 0.633; DeLong test, all P < 0.05). CONCLUSION: The nomogram, constructed from a multivariable model, effectively discriminates and calibrates POPF risk following splenectomy in patients with WD, offering potential clinical utility. Particular attention should be paid to history of abdominal surgery and operation time, with preoperative individualized interventions tailored accordingly. FAU - Zheng, Zhou AU - Zheng Z AD - Anhui University of Chinese Medicine, 350 Longzi Lake Road, Anhui, China. AD - The Second Affiliated Hospital of Anhui, University of Chinese Medicine, 300 Shou Chun Road, Hefei, Anhui, China. FAU - Shen, Yi AU - Shen Y AD - Anhui University of Chinese Medicine, 350 Longzi Lake Road, Anhui, China. AD - The First Affiliated Hospital of Anhui University of Chinese Medicine, 117 Mei Shan Road, Hefei, Anhui, 230031, China. FAU - Min, Hui-Cong AU - Min HC AD - Anhui University of Chinese Medicine, 350 Longzi Lake Road, Anhui, China. AD - The First Affiliated Hospital of Anhui University of Chinese Medicine, 117 Mei Shan Road, Hefei, Anhui, 230031, China. FAU - Peng, Hui AU - Peng H AD - The First Affiliated Hospital of Anhui University of Chinese Medicine, 117 Mei Shan Road, Hefei, Anhui, 230031, China. FAU - Huang, Long AU - Huang L AD - The First Affiliated Hospital of Anhui University of Chinese Medicine, 117 Mei Shan Road, Hefei, Anhui, 230031, China. FAU - Zhang, Wan-Zong AU - Zhang WZ AD - The Third Affiliated Hospital of Anhui University of Chinese Medicine, 45 Shi He Road, Hefei, Anhui, China. FAU - Feng, Hui AU - Feng H AD - The First Affiliated Hospital of Anhui University of Chinese Medicine, 117 Mei Shan Road, Hefei, Anhui, 230031, China. FAU - Yu, Qing-Sheng AU - Yu QS AD - Anhui University of Chinese Medicine, 350 Longzi Lake Road, Anhui, China. qsy6312@163.com. AD - The First Affiliated Hospital of Anhui University of Chinese Medicine, 117 Mei Shan Road, Hefei, Anhui, 230031, China. qsy6312@163.com. LA - eng GR - 202427b10020023/Anhui Provincial Clinical Medical Research Transformation Project/ GR - 82374208/National Natural Science Foundation of China/ PT - Journal Article DEP - 20251125 PL - England TA - BMC Gastroenterol JT - BMC gastroenterology JID - 100968547 SB - IM MH - Humans MH - Retrospective Studies MH - *Splenectomy/adverse effects MH - Female MH - Male MH - Risk Factors MH - *Hypertension, Portal/etiology/surgery/complications MH - Adult MH - *Nomograms MH - *Hepatolenticular Degeneration/complications/surgery MH - *Pancreatic Fistula/etiology/epidemiology MH - *Postoperative Complications/etiology/epidemiology MH - Young Adult MH - Splenomegaly/etiology/surgery MH - ROC Curve MH - Logistic Models MH - Adolescent MH - Risk Assessment/methods MH - Incidence MH - Hypersplenism/surgery/etiology PMC - PMC12751975 COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of the First Affiliated Hospital of Anhui University of Chinese Medicine (Approval No. 2019AH-32; Registration date: January 25, 2020) and registered in the Chinese Clinical Trial Registry (ChiCTR2000034137; Registration date: June 30, 2020). It adhered to the Declaration of Helsinki, and informed consent was waived owing to its retrospective design and the protection of patient privacy. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/26 06:29 MHDA- 2026/06/27 06:44 PMCR- 2025/11/25 CRDT- 2025/11/26 00:02 PHST- 2025/08/26 00:00 [received] PHST- 2025/11/10 00:00 [accepted] PHST- 2026/06/27 06:44 [medline] PHST- 2025/11/26 06:29 [pubmed] PHST- 2025/11/26 00:02 [entrez] PHST- 2025/11/25 00:00 [pmc-release] AID - 10.1186/s12876-025-04475-w [pii] AID - 4475 [pii] AID - 10.1186/s12876-025-04475-w [doi] PST - epublish SO - BMC Gastroenterol. 2025 Nov 25;25(1):884. doi: 10.1186/s12876-025-04475-w. PMID- 41291351 OWN - NLM STAT- MEDLINE DCOM- 20260313 LR - 20260920 IS - 1179-2035 (Electronic) IS - 0112-1642 (Print) IS - 0112-1642 (Linking) VI - 56 IP - 2 DP - 2026 Feb TI - Effects of the FIFA 11 + Program on Physical Fitness in Youth and Adult Soccer Players: A Systematic Review and Meta-analysis. PG - 521-541 LID - 10.1007/s40279-025-02346-8 [doi] AB - BACKGROUND: Soccer is a high-intensity sport that requires high levels of physical fitness, including balance, change of direction (CoD), speed and power. The FIFA 11 + program has been widely promoted to enhance physical fitness and reduce injury occurrence. OBJECTIVE: This meta-analysis set out to examine how the FIFA 11 + program, implemented as a warm-up versus conventional warm-up (soccer-specific and alternative warm-ups), impacts physical fitness attributes in youth and adult soccer players. METHODS: After a priori defined inclusion and exclusion criteria, 17 intervention studies with 611 male and female soccer players (Tier 2-4) aged 9-29 years were eligible to be included. The FIFA 11 + program implemented in the warm-up was contrasted with conventional warm-up programs (control) on outcome measures such as dynamic balance, CoD speed, linear sprint and proxies of muscle power (vertical jump height). The influence of potential moderators (e.g., training duration, frequency, session duration, age, sex, training and performance calibre) on study outcome measures was examined using subgroup analyses with the median split method. RESULTS: Findings demonstrated small-to-moderate improvements in favour of FIFA 11 + compared with conventional warm-ups on dynamic balance (small standardized mean differences [SMDs] = 0.37, p < 0.001, heterogeneity [I(2)] = 7), CoD speed (moderate SMDs = - 0.65, p = 0.005, I(2) = 84), and vertical jump height (small SMDs = 0.56, p < 0.001, I(2) = 71). Results from the sub-analyses showed that, for dynamic balance, shorter training durations (< 9 weeks) produced larger effects than longer durations (>/= 9 weeks) (SMDs = 0.62 versus SMDs = 0.17). For vertical jump height, < 9 weeks also yielded greater improvements (SMDs = 0.79 versus SMDs = 0.26). In terms of weekly training frequency, >/= 3 sessions/week elicited larger gains in change-of-direction speed (SMDs = - 1.05 versus SMDs = - 0.12) and vertical jump height (SMDs = 0.73 versus SMDs = 0.01) compared with < 3 sessions/week. Regarding participant characteristics, players aged >/= 18 years showed greater improvements than those < 18 years in change-of-direction speed (SMDs = - 1.45 versus SMDs = - 0.06) and vertical jump height (SMDs = 0.64 versus SMDs = 0.22). For sex differences, males experienced greater benefits than females in change-of-direction speed (SMDs = - 0.79 versus SMDs = - 0.04) and vertical jump height (SMDs = 0.54 versus SMDs = 0.09). Finally, higher-level players (>/= tier 3) demonstrated greater improvements in vertical jump height than lower-tier players (< Tier 3) (SMDs = 0.75 versus SMDs = 0.01). The observed benefits were statistically significant but generally of small-to-moderate magnitude and affected by study heterogeneity and program implementation differences. Most studies included male participants, limiting generalizability to female and underrepresented populations. Several studies also lacked rigorous methodological design, particularly in allocation, concealment and blinding. Reporting of training and demographic variables was often incomplete. These limitations highlight the necessity for rigorously designed, low-bias randomized controlled trials with standardized implementation of the FIFA 11 + program and thorough reporting to enhance the reliability of causal conclusions and improve clinical interpretation. CONCLUSION: The FIFA 11 + program was more effective than conventional soccer warm-up programs to enhance soccer players' physical fitness (i.e., dynamic balance, CoD speed, vertical jump height). A shorter training duration (< 9 weeks) and more weekly training sessions (>/= 3 sessions/week) induced larger performance effects. FIFA 11 + was more effective in older (>/= 18 years) and male players and in players of higher performance calibre (>/= Tier 3). These findings underscore the versatility of the FIFA 11 + program to improve soccer players' physical fitness, supporting its integration into the warm-up of regular soccer training sessions. PROTOCOL REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/view/CRD42025633810 , PROSPERO: CRD42025633810. CI - (c) 2025. The Author(s). FAU - Kambitta Valappil, Ibnu Noufal AU - Kambitta Valappil IN AD - Department of Physical Education and Sports, Pondicherry University, Puducherry, 605014, India. FAU - Govindasamy, Karuppasamy AU - Govindasamy K AD - Department of Sports, Recreation and Wellness, Symbiosis International (Deemed University), Hyderabad Campus, Modallaguda (V), Nandigama (M), Rangareddy, Telangana, 509217, India. FAU - Vasanthi, Gavoutamane AU - Vasanthi G AD - Department of Physical Education and Sports, Pondicherry University, Puducherry, 605014, India. FAU - Elayaraja, Masilamani AU - Elayaraja M AD - Department of Physical Education and Sports, Pondicherry University, Puducherry, 605014, India. FAU - Clark, Cain C T AU - Clark CCT AD - College of Life Sciences, Birmingham City University, Birmingham, B15 3TN, UK. FAU - Parpa, Koulla AU - Parpa K AD - Faculty of Sport and Exercise Science, UCLan University of Cyprus, 7080, Pyla, Cyprus. FAU - Katanic, Borko AU - Katanic B AD - Montenergin Sports Academy, Podgorica, Montenegro. FAU - Uysal, Huseyin Sahin AU - Uysal HS AD - Department of Physical Education and Sport, Faculty of Sport Sciences, Burdur Mehmet Akif Ersoy University, 15030, Burdur, Turkey. FAU - Zouhal, Hassane AU - Zouhal H AD - Institut International des Sciences du Sport (2I2S), 35850, Irodouer, France. AD - Laboratoire optimisation de la performance sportive, centre national de la medecine et des sciences des sports, (LR09SEP01), Tunis, Tunisia. FAU - Granacher, Urs AU - Granacher U AUID- ORCID: 0000-0002-7095-813X AD - Department of Sport and Sport Science, Exercise and Human Movement Science, University of Freiburg, 79102, Freiburg, Germany. Urs.Granacher@sport.uni-freiburg.de. LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Systematic Review DEP - 20251125 PL - New Zealand TA - Sports Med JT - Sports medicine (Auckland, N.Z.) JID - 8412297 SB - IM MH - Humans MH - *Soccer/physiology MH - *Physical Fitness/physiology MH - Adolescent MH - *Warm-Up Exercise/physiology MH - Child MH - Athletic Performance/physiology MH - Young Adult MH - Muscle Strength MH - Adult MH - Male MH - Female MH - Postural Balance PMC - PMC12982247 COIS- Declarations. Funding: We acknowledge support by the Open Access Publication Fund of the University of Freiburg, Germany. Ethics approval: Not applicable. Consent to participate: Not applicable. Consent for publication: Not applicable. Code availability: Not applicable. Conflict of interest: The authors declare they that have no conflicts of interest with the content of this article. Urs Granacher is a member of the editorial board of Sports Medicine but was not involved in the selection of reviewers for this manuscript or in any of the subsequent editorial decisions. Availability of data and material: The data are provided in Table 4 and Electronic Supplementary Material [1], with further datasets available from the corresponding author upon reasonable request. Authors' contribution: Conceptualization: INKV, KG. Literature search: INKV, KG, GV. Abstract screening, full-text eligibility assessment, data extraction and critical appraisal: INKV, KG, GV, ME, HSU, UG. Data synthesis: INKV, KG, CCTC, KP, BK, HZ, UG. Original draft of manuscript: INKV, KG, UG. Manuscript review and edit: INKV, CCTC, KP, BK, HSU, HZ, UG. All authors read and approved the final manuscript. EDAT- 2025/11/26 00:27 MHDA- 2026/03/13 06:52 PMCR- 2025/11/25 CRDT- 2025/11/25 23:58 PHST- 2025/10/16 00:00 [accepted] PHST- 2026/03/13 06:52 [medline] PHST- 2025/11/26 00:27 [pubmed] PHST- 2025/11/25 23:58 [entrez] PHST- 2025/11/25 00:00 [pmc-release] AID - 10.1007/s40279-025-02346-8 [pii] AID - 2346 [pii] AID - 10.1007/s40279-025-02346-8 [doi] PST - ppublish SO - Sports Med. 2026 Feb;56(2):521-541. doi: 10.1007/s40279-025-02346-8. Epub 2025 Nov 25. PMID- 41291116 OWN - NLM STAT- MEDLINE DCOM- 20251230 LR - 20261017 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Nov 25 TI - Feasibility of accelerometer-based prediction of postural balance in schoolchildren using machine learning models. PG - 45349 LID - 10.1038/s41598-025-30160-9 [doi] LID - 45349 AB - Objective assessment of balance during childhood is essential for supporting motor development, preventing falls, and identifying potential impairments. Traditional clinical tests, such as the Flamingo and balance beam, are widely used but remain limited by subjectivity and lack of precision. Accelerometry offers quantitative measures, and its integration with machine learning models provides an opportunity to explore predictive assessment in pediatric populations. This study evaluated the feasibility of predicting clinical balance test outcomes in schoolchildren using accelerometric data from both static and dynamic tasks. A cross-sectional study was conducted with 90 children aged 6 to 12 years. Accelerometric signals were recorded in three axes and magnitude during static tasks (eyes closed, eyes open, and unstable surface) and during gait. Outcomes included the number of supports in the Flamingo test and the distance covered in the balance beam test. Several machine learning models, including linear regression, penalized regression, k-nearest neighbors, support vector regression, and random forest, were applied using 5-fold cross-validation. Models showed modest but consistent predictive accuracy for the Flamingo test, particularly with static tasks, with random forest, support vector regression, and k-nearest neighbors performing best. Prediction of balance beam outcomes was poor across all models. These findings suggest that accelerometry-based machine learning is feasible for predicting balance performance in children, especially for the Flamingo test, supporting its potential as a digital tool for screening and educational health applications. CI - (c) 2025. The Author(s). FAU - Benitez-Andrades, Jose Alberto AU - Benitez-Andrades JA AD - ALBA Research Group, Department of Electric, Systems and Automatics Engineering, University of Leon, Campus of Vegazana s/n, 24071, Leon, Castilla y Leon, Spain. jbena@unileon.es. FAU - Gonzalez-Castro, Ana AU - Gonzalez-Castro A AD - Department of Nursing and Physical Therapy, Faculty of Health Sciences, University of Leon, Campus de Ponferrada, 24401, Ponferrada, Castilla y Leon, Spain. FAU - Gonzalez-Marcos, Elena AU - Gonzalez-Marcos E AD - ALBA Research Group, Department of Electric, Systems and Automatics Engineering, University of Leon, Campus of Vegazana s/n, 24071, Leon, Castilla y Leon, Spain. FAU - Rubio-Martin, Sergio AU - Rubio-Martin S AD - ALBA Research Group, Department of Electric, Systems and Automatics Engineering, University of Leon, Campus of Vegazana s/n, 24071, Leon, Castilla y Leon, Spain. FAU - Leiros-Rodriguez, Raquel AU - Leiros-Rodriguez R AD - SALBIS Research Group, Department of Nursing and Physical Therapy, Faculty of Health Sciences, University of Leon, Campus de Ponferrada, 24401, Ponferrada, Castilla y Leon, Spain. FAU - Prada-Garcia, Camino AU - Prada-Garcia C AD - Department of Preventive Medicine and Public Health, University of Valladolid, 47005, Valladolid, Castilla y Leon, Spain. AD - Dermatology Service, Complejo Asistencial Universitario de Leon, 24008, Leon, Castilla y Leon, Spain. LA - eng SI - Dataset DOI/10.5281/zenodo.16888953 PT - Journal Article DEP - 20251125 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Child MH - *Postural Balance/physiology MH - *Accelerometry/methods MH - Male MH - Female MH - *Machine Learning MH - Cross-Sectional Studies MH - Feasibility Studies MH - Gait/physiology PMC - PMC12748716 OTO - NOTNLM OT - Accelerometry OT - Clinical informatics OT - Digital health OT - Machine learning OT - Postural balance OT - Schoolchildren COIS- Declarations. Competing interests: The authors declare that they have no conflicts of interest to this work. The people involved in the experiment have been informed and formally accepted. Consent for publication: Not applicable. This manuscript does not contain personal data, images, or videos from any individual. EDAT- 2025/11/26 00:27 MHDA- 2025/12/30 07:41 PMCR- 2025/11/25 CRDT- 2025/11/25 23:50 PHST- 2025/08/26 00:00 [received] PHST- 2025/11/21 00:00 [accepted] PHST- 2025/12/30 07:41 [medline] PHST- 2025/11/26 00:27 [pubmed] PHST- 2025/11/25 23:50 [entrez] PHST- 2025/11/25 00:00 [pmc-release] AID - 10.1038/s41598-025-30160-9 [pii] AID - 30160 [pii] AID - 10.1038/s41598-025-30160-9 [doi] PST - epublish SO - Sci Rep. 2025 Nov 25;15(1):45349. doi: 10.1038/s41598-025-30160-9. PMID- 41290750 OWN - NLM STAT- MEDLINE DCOM- 20251125 LR - 20261019 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Nov 25 TI - Validation of mid-upper arm circumference against to body mass index-for-age for assessing nutritional status among school adolescents in Ethiopia. PG - 41896 LID - 10.1038/s41598-025-25786-8 [doi] LID - 41896 AB - Body mass index-for-age (BMI-for-age) is widely used indicator to assess the nutritional status of adolescent, however, its application in field settings can be challenging due to equipment and logistical constraints. Mid-upper arm circumference (MUAC) offers a simpler, low resource alternative, but its accuracy and validity among adolescents remain a subject of debate. This study aims to validate MUAC as a feasible alternative for assessing nutritional status in resource-limited settings like Ethiopia. Particularly, the study aimed to evaluate the screening performance of MUAC in detecting thinness compared to BMI-for-age Z-scores (BAZ) and to determine optimal MUAC cut-off points identifying undernutrition status among school students (10-19 years) in the West Hararge zone of Oromia, Ethiopia. A school based cross-sectional study was conducted involved 706 adolescents recruited from 10 schools in the West Harerghe Zone, Oromiia, Ethiopia. Participants were selected using a combination of simple random sampling at the school level and multistage sampling within schools. MUAC was measured on the left arm at the midpoint between the acromion and olecranon using a non-stretchable tape. Body mass index (BMI) was calculated from weight and height measurements taken using calibrated SECA electronic weighing scale (UNICEF) and a SECA portable stadiometer (SECA 213) respectively. All anthropometric measurements adhered to standardized World Health Organization (WHO) guidelines. The diagnostic performance of MUAC in predictor of thinness, as defined by BAZ was evaluated using sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and receiver operating characteristic (ROC) curve analysis. The area under the ROC curve (AUC) for MUAC in detecting thinness compared to against BAZ was 0.76 (95% CI: 0.69-0.85) for adolescents aged 10-14 year group and 0.83 (95% CI: 0.68-0.96) for those aged 15-19 year group. Optimal MUAC cut-offs for detecting thinness were /=63 hours per week of smartphone screen time had 22% higher odds of poor sleep (OR 1.22, 95% CI 1.08-1.37) and a 6.66-minute-shorter nighttime sleep duration (beta=-6.66, 95% CI -10.19 to -3.13) compared to those with 0 to 21 hours of screen time per week, whereas those with approximately 21 to 42 hours per week of smartphone screen time had a 5.47-minute-longer nighttime sleep duration (beta=5.47, 95% CI 1.28-9.65). Similarly, compared to those with 0 to 50 smartphone unlocks per week, participants with >/=400 smartphone unlocks per week showed 61% higher odds of poor sleep (OR 1.61, 95% CI 1.41-1.85) accompanied by a 4.09-minute-shorter nighttime sleep duration (beta=-4.09, 95% CI -8.08 to -0.09), whereas those with approximately 50 to 150 smartphone unlocks per week had a 5.84-minute-longer sleep duration (beta=5.84, 95% CI 2.32-9.36). An inverted U-shaped association between smartphone screen time and sleep duration was observed (P<.001 for nonlinearity). CONCLUSIONS: Smartphone addiction, excessive objectively measured smartphone screen time, and unlocks are positively associated with both sleep quality and duration. Restricted cubic spline analyses revealed different nuanced dose-response relationships, with an inverted U-shaped association observed between smartphone screen time and sleep duration. CI - (c) Jian Yin, Xuanyi Tang, Zeshi Liu, Yangyang Gong, Hui Yang, Yanping Zhang. Originally published in JMIR Mental Health (https://mental.jmir.org). FAU - Yin, Jian AU - Yin J AUID- ORCID: 0009-0008-2121-7037 AD - Department of Laboratory, Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 West Five Road, Xi'an, 710004, China, +86-15929443510. FAU - Tang, Xuanyi AU - Tang X AUID- ORCID: 0009-0005-7503-5683 AD - School of Public Health, Shandong University, Jinan, China. FAU - Liu, Zeshi AU - Liu Z AUID- ORCID: 0009-0001-2429-4440 AD - Department of Laboratory, Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 West Five Road, Xi'an, 710004, China, +86-15929443510. FAU - Gong, Yangyang AU - Gong Y AUID- ORCID: 0009-0006-9179-4214 AD - Department of Laboratory, Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 West Five Road, Xi'an, 710004, China, +86-15929443510. FAU - Yang, Hui AU - Yang H AUID- ORCID: 0009-0000-9342-6729 AD - Department of External Cooperation and Exchange, Shaanxi Provincial Health Commission, Xi'an, China. FAU - Zhang, Yanping AU - Zhang Y AUID- ORCID: 0009-0000-8019-8966 AD - Department of Laboratory, Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 West Five Road, Xi'an, 710004, China, +86-15929443510. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251125 PL - Canada TA - JMIR Ment Health JT - JMIR mental health JID - 101658926 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Female MH - Universities MH - *Students/statistics & numerical data/psychology MH - *Sleep Quality MH - Young Adult MH - Adult MH - *Smartphone/statistics & numerical data MH - China/epidemiology MH - *Internet Addiction Disorder/epidemiology MH - Surveys and Questionnaires MH - Adolescent MH - Sleep PMC - PMC12646561 OTO - NOTNLM OT - sleep disorders OT - sleep duration OT - smartphone addiction OT - smartphone screen time OT - smartphone unlocks COIS- Conflicts of Interest: None declared. EDAT- 2025/11/25 18:30 MHDA- 2025/11/25 18:31 PMCR- 2025/11/25 CRDT- 2025/11/25 16:23 PHST- 2025/05/20 00:00 [received] PHST- 2025/10/01 00:00 [revised] PHST- 2025/10/02 00:00 [accepted] PHST- 2025/11/25 18:31 [medline] PHST- 2025/11/25 18:30 [pubmed] PHST- 2025/11/25 16:23 [entrez] PHST- 2025/11/25 00:00 [pmc-release] AID - v12i1e77796 [pii] AID - 77796 [pii] AID - 10.2196/77796 [doi] PST - epublish SO - JMIR Ment Health. 2025 Nov 25;12:e77796. doi: 10.2196/77796. PMID- 41289507 OWN - NLM STAT- MEDLINE DCOM- 20260416 LR - 20260416 IS - 2769-707X (Electronic) IS - 2769-7061 (Linking) VI - 45 IP - 4 DP - 2026 May-Jun TI - Dietary Intake of Polyphenols in Adults Residing in Chile: A Descriptive Cross-Sectional Study. PG - 347-354 LID - 10.1080/27697061.2025.2585825 [doi] AB - BACKGROUND: Polyphenols have been recognized for their protective role against chronic noncommunicable diseases. Despite growing international evidence, studies assessing polyphenol intake in Latin American populations remain scarce, particularly in Chile, where profound nutritional transitions have increased the consumption of ultra-processed foods and the burden of obesity and cardiovascular disease. OBJECTIVE: This study aimed to quantify dietary polyphenol intake in the Chilean adult population using a validated self-reported food frequency questionnaire. METHODS: A descriptive cross-sectional design was conducted in 521 adults aged >/=18 years, residing in different Chilean macrozones. Sociodemographic, anthropometric, and lifestyle data were collected, and polyphenol intake was estimated. RESULTS: The mean age of participants was 33.3 +/- 10.1 years, with a predominance of women. The average daily intake of polyphenols was 1634.9 +/- 1168.6 mg/d, with higher, though non-significant, consumption observed among women, rural residents, and individuals from the northern macrozone. Age-stratified analysis showed that men >/=30 years consumed significantly more polyphenols than younger men. CONCLUSION: Fruits represented the main dietary source, followed by coffee and tea, while wine and cider contributed minimally. FAU - Guzman-Pincheira, Carla AU - Guzman-Pincheira C AUID- ORCID: 0000-0002-9173-7504 AD - Escuela de Nutricion y Dietetica, Facultad de Ciencias de la Rehabilitacion y Calidad de Vida, Universidad San Sebastian, Concepcion, Chile. FAU - Romero-Vera, Esteban AU - Romero-Vera E AD - Escuela de Nutricion y Dietetica, Facultad de Medicina, Universidad Catolica de la Santisima Concepcion, Concepcion, Chile. FAU - Sepulveda-Caro, Dyana AU - Sepulveda-Caro D AD - Escuela de Nutricion y Dietetica, Facultad de Ciencias de la Rehabilitacion y Calidad de Vida, Universidad San Sebastian, Concepcion, Chile. FAU - Gacitua-Riquelme, Felipe AU - Gacitua-Riquelme F AD - Escuela de Nutricion y Dietetica, Facultad de Salud y Ciencias Sociales, Universidad de las Americas, Concepcion, Chile. FAU - Benedetti-Ibanez, Gabriela AU - Benedetti-Ibanez G AD - Escuela de Nutricion y Dietetica, Facultad de Farmacia, Universidad de Concepcion, Concepcion, Chile. FAU - Guzman-Oyarzo, Dina AU - Guzman-Oyarzo D AD - Escuela de Tecnologia Medica, Facultad de Ciencias, Universidad San Sebastian, Concepcion, Chile. FAU - Quintero-Florez, Angelica AU - Quintero-Florez A AD - Departamento de Medicina Preventiva y Salud Publica, Facultad de Medicina, Universidad de Sevilla, Seville, Spain. FAU - Araujo-Silva, Gabriel AU - Araujo-Silva G AD - Organic Chemistry and Biochemistry Laboratory, Amapa State University (UEAP), Macapa, Brazil. LA - eng PT - Journal Article DEP - 20251125 PL - United States TA - J Am Nutr Assoc JT - Journal of the American Nutrition Association JID - 9918300687506676 RN - 0 (Polyphenols) SB - IM MH - Humans MH - Chile MH - Female MH - Cross-Sectional Studies MH - Male MH - Adult MH - *Polyphenols/administration & dosage MH - Middle Aged MH - *Diet MH - Young Adult MH - Fruit MH - Adolescent OTO - NOTNLM OT - Antioxidants OT - dietary bioactive peptides OT - food intake OT - polyphenols EDAT- 2025/11/25 18:30 MHDA- 2026/04/19 17:39 CRDT- 2025/11/25 15:02 PHST- 2026/04/19 17:39 [medline] PHST- 2025/11/25 18:30 [pubmed] PHST- 2025/11/25 15:02 [entrez] AID - 10.1080/27697061.2025.2585825 [doi] PST - ppublish SO - J Am Nutr Assoc. 2026 May-Jun;45(4):347-354. doi: 10.1080/27697061.2025.2585825. Epub 2025 Nov 25. PMID- 41287867 OWN - NLM STAT- Publisher LR - 20251126 IS - 1743-9159 (Electronic) IS - 1743-9159 (Linking) DP - 2025 Nov 24 TI - Nomogram for predicting type 2 diabetes remission after bariatric metabolic surgery in women: a multicenter cohort study. LID - 10.1097/JS9.0000000000004079 [doi] AB - BACKGROUND: The prevalence of obesity with type 2 diabetes mellitus (T2DM) among Asian women has been increasing. However, systematic studies on diabetes prevalence and postoperative remission after metabolic and bariatric surgery (MBS) in this population remain limited. This study aimed to identify risk factors for T2DM in women with obesity undergoing MBS and to develop and validate a predictive model for diabetes remission (DR) at 1-year post-MBS as the primary outcome. METHODS: This study utilized a 10-year cohort dataset (2014-2024) from 128 bariatric centers in China, involving 7,322 women with obesity who underwent MBS. Univariate and multivariate logistic regression analyses were performed to identify the risk factors of diabetes and predictors of DR, and a nomogram model was constructed and internally validated. RESULTS: A total of 1,440 individuals had T2DM, accounting for 19.7% of the total study population. Factors associated with the prevalence of T2DM in women with obesity included age, follicle-stimulating hormone level, family history of diabetes, hemoglobin A1c (HbA1c), and fasting plasma glucose. Within the diabetic population, the median age was 35 years, and the median BMI was 36.1 kg/m 2 . Independent factors influencing postoperative DR included family history of diabetes, postpartum obesity, childhood-onset obesity, diabetes duration, HbA1c level, and insulin requirement. The nomogram model demonstrated excellent discrimination and calibration in both the training and validation sets, with decision curve analysis confirming its clinical utility. CONCLUSIONS: This study identified risk factors for T2DM in Chinese women with obesity and, established and validated a DR-predictive nomogram for T2DM in Chinese women with obesity after MBS. The model incorporates female-specific factors (e.g., postpartum obesity) and may serve as a reliable tool for personalized surgical decision-making and postoperative management. CI - Copyright (c) 2025 The Author(s). Published by Wolters Kluwer Health, Inc. FAU - Wu, Zilong AU - Wu Z AD - Department of Gastrointestinal Surgery/Bariatric Surgery Center, The First Affiliated Hospital of Jinan University, Guangzhou, PR China. AD - The Guangdong-Hong Kong-Macao Joint University Laboratory of Metabolic and Molecular Medicine, Jinan University, Guangzhou, PR China. FAU - Wang, Dehui AU - Wang D AD - Department of Gastrointestinal Surgery/Bariatric Surgery Center, The First Affiliated Hospital of Jinan University, Guangzhou, PR China. AD - The Guangdong-Hong Kong-Macao Joint University Laboratory of Metabolic and Molecular Medicine, Jinan University, Guangzhou, PR China. FAU - Li, Jie AU - Li J AD - School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, PR China. FAU - Chen, Sijie AU - Chen S AD - Department of Nursing, Chengdu Fifth People's Hospital, Chengdu, PR China. FAU - Chen, Yaoyao AU - Chen Y AD - School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, PR China. FAU - Wu, Bing AU - Wu B AD - Department of Gastrointestinal Surgery/Bariatric Surgery Center, The First Affiliated Hospital of Guizhou Medical University, Guizhou, PR China. FAU - Liu, Yun AU - Liu Y AD - School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, PR China. FAU - Yang, Wah AU - Yang W AD - Department of Gastrointestinal Surgery/Bariatric Surgery Center, The First Affiliated Hospital of Jinan University, Guangzhou, PR China. AD - The Guangdong-Hong Kong-Macao Joint University Laboratory of Metabolic and Molecular Medicine, Jinan University, Guangzhou, PR China. FAU - Hu, Ruixiang AU - Hu R AD - Department of Gastrointestinal Surgery/Bariatric Surgery Center, The First Affiliated Hospital of Jinan University, Guangzhou, PR China. AD - The Guangdong-Hong Kong-Macao Joint University Laboratory of Metabolic and Molecular Medicine, Jinan University, Guangzhou, PR China. FAU - Wang, Cunchuan AU - Wang C AD - Department of Gastrointestinal Surgery/Bariatric Surgery Center, The First Affiliated Hospital of Jinan University, Guangzhou, PR China. AD - The Guangdong-Hong Kong-Macao Joint University Laboratory of Metabolic and Molecular Medicine, Jinan University, Guangzhou, PR China. LA - eng PT - Journal Article DEP - 20251124 PL - United States TA - Int J Surg JT - International journal of surgery (London, England) JID - 101228232 SB - IM OTO - NOTNLM OT - diabetes remission OT - metabolic and bariatric surgery OT - prediction model OT - type 2 diabetes mellitus OT - women with obesity EDAT- 2025/11/25 06:26 MHDA- 2025/11/25 06:26 CRDT- 2025/11/25 04:56 PHST- 2025/08/13 00:00 [received] PHST- 2025/11/04 00:00 [accepted] PHST- 2025/11/25 06:26 [pubmed] PHST- 2025/11/25 06:26 [medline] PHST- 2025/11/25 04:56 [entrez] AID - 01279778-990000000-03830 [pii] AID - 10.1097/JS9.0000000000004079 [doi] PST - aheadofprint SO - Int J Surg. 2025 Nov 24. doi: 10.1097/JS9.0000000000004079. PMID- 41287084 OWN - NLM STAT- MEDLINE DCOM- 20251125 LR - 20260918 IS - 1824-7288 (Electronic) IS - 1720-8424 (Linking) VI - 51 IP - 1 DP - 2025 Nov 24 TI - Development and validation of an online nomogram for screening metabolic-associated fatty liver disease in obese children. PG - 307 LID - 10.1186/s13052-025-02151-z [doi] LID - 307 AB - BACKGROUND: Metabolic-associated fatty liver disease (MAFLD) has emerged as a critical pediatric health concern, particularly among children with obesity. However, its diagnosis poses substantial challenges, especially in the use of non-invasive methods. Our goal was to construct an online nomogram for screening MAFLD in obese children. METHODS: We designed a retrospective cross-sectional study involving 2,512 obese children. Detailed anthropometric data and laboratory parameters were collected. The study dataset was randomly allocated into training (n = 1758) and validation (n = 754) sets at a 7:3 ratio. To identify MAFLD risk factors, we conducted logistic regression analyses, from which a web-based predictive nomogram was constructed. Using receiver operating characteristic (ROC) curves and area under the curve (AUC), the nomogram's performance was assessed and contrasted with the triglyceride glucose (TyG) index, Zhejiang University (ZJU) index, and Korean NAFLD (K-NAFLD) score. The goodness-of-fit of the nomogram was evaluated using calibration plots, and the nomogram's clinical value was assessed using decision curve analysis (DCA). RESULTS: A total of 1,344 participants (53.50%) were diagnosed with MAFLD by ultrasound. Age, gender, BMI Z-score, waist circumference (WC), homeostatic model assessment of insulin resistance (HOMA-IR), and alanine aminotransferase (ALT) were identified as independent factors influencing MAFLD in obese children. These six variables were selected for the construction of the nomogram. ROC analysis revealed that the nomogram had superior diagnostic performance for MAFLD detection compared to the other three models, with AUC values of 0.874 (95% confidence interval [CI]: 0.858-0.890) in the training set and 0.870 (95% CI: 0.845-0.895) in the validation set. Calibration plots indicated a good fit of the nomogram in both datasets. Furthermore, DCA demonstrated its strong clinical applicability. CONCLUSIONS: This study developed an online nomogram that demonstrates robust diagnostic accuracy and clinical utility for assessing obese children's MAFLD risk. CI - (c) 2025. The Author(s). FAU - Hu, Jiaqian AU - Hu J AD - Tianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China. AD - Innovation Center for Basic Medical Research of Metabolic Associated Fatty Liver Disease, Ministry of Education, Zhengzhou, Henan, China. AD - Department of Endocrine Genetic Metabolism, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China. FAU - Wang, Mengqin AU - Wang M AD - Tianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China. AD - Innovation Center for Basic Medical Research of Metabolic Associated Fatty Liver Disease, Ministry of Education, Zhengzhou, Henan, China. AD - Department of Endocrine Genetic Metabolism, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China. FAU - Wang, Xi AU - Wang X AD - Tianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China. AD - Innovation Center for Basic Medical Research of Metabolic Associated Fatty Liver Disease, Ministry of Education, Zhengzhou, Henan, China. AD - Department of Endocrine Genetic Metabolism, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China. FAU - Guo, Mingwei AU - Guo M AD - Tianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China. AD - Innovation Center for Basic Medical Research of Metabolic Associated Fatty Liver Disease, Ministry of Education, Zhengzhou, Henan, China. AD - Department of Endocrine Genetic Metabolism, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China. FAU - Lu, Yaqing AU - Lu Y AD - Tianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China. AD - Innovation Center for Basic Medical Research of Metabolic Associated Fatty Liver Disease, Ministry of Education, Zhengzhou, Henan, China. AD - Department of Endocrine Genetic Metabolism, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China. FAU - Zhang, Zixia AU - Zhang Z AD - Tianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China. AD - Innovation Center for Basic Medical Research of Metabolic Associated Fatty Liver Disease, Ministry of Education, Zhengzhou, Henan, China. AD - Department of Endocrine Genetic Metabolism, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China. FAU - Li, Miaomiao AU - Li M AD - Tianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China. AD - Innovation Center for Basic Medical Research of Metabolic Associated Fatty Liver Disease, Ministry of Education, Zhengzhou, Henan, China. AD - Department of Endocrine Genetic Metabolism, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China. FAU - Sun, Guiying AU - Sun G AD - Clinical Epidemiology Research Center, Affiliated Children's Hospital of Zhengzhou University, Zhengzhou, Henan, China. FAU - Ma, Xiaocui AU - Ma X AD - Tianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China. AD - Key Laboratory of Pediatric Inherited Metabolic Diseases, Affiliated Children's Hospital of Zhengzhou University, Zhengzhou, Henan, China. FAU - Zhang, Yaodong AU - Zhang Y AD - Key Laboratory of Pediatric Inherited Metabolic Diseases, Affiliated Children's Hospital of Zhengzhou University, Zhengzhou, Henan, China. FAU - Zhang, Wancun AU - Zhang W AD - Key Laboratory of Pediatric Inherited Metabolic Diseases, Affiliated Children's Hospital of Zhengzhou University, Zhengzhou, Henan, China. FAU - Li, Dongxiao AU - Li D AD - Tianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China. AD - Key Laboratory of Pediatric Inherited Metabolic Diseases, Affiliated Children's Hospital of Zhengzhou University, Zhengzhou, Henan, China. FAU - Chen, Yongxing AU - Chen Y AD - Tianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China. AD - Innovation Center for Basic Medical Research of Metabolic Associated Fatty Liver Disease, Ministry of Education, Zhengzhou, Henan, China. AD - Department of Endocrine Genetic Metabolism, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China. FAU - Luo, Shuying AU - Luo S AD - Tianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China. shyluo@163.com. AD - Innovation Center for Basic Medical Research of Metabolic Associated Fatty Liver Disease, Ministry of Education, Zhengzhou, Henan, China. shyluo@163.com. AD - Department of Endocrine Genetic Metabolism, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China. shyluo@163.com. FAU - Wei, Haiyan AU - Wei H AUID- ORCID: 0000-0003-1044-6594 AD - Tianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China. haiyanwei2009@163.com. AD - Innovation Center for Basic Medical Research of Metabolic Associated Fatty Liver Disease, Ministry of Education, Zhengzhou, Henan, China. haiyanwei2009@163.com. AD - Department of Endocrine Genetic Metabolism, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China. haiyanwei2009@163.com. LA - eng PT - Journal Article PT - Validation Study DEP - 20251124 PL - England TA - Ital J Pediatr JT - Italian journal of pediatrics JID - 101510759 SB - IM MH - Humans MH - *Nomograms MH - Male MH - Female MH - Retrospective Studies MH - Cross-Sectional Studies MH - *Pediatric Obesity/complications MH - Child MH - *Non-alcoholic Fatty Liver Disease/diagnosis MH - *Mass Screening/methods MH - ROC Curve MH - Adolescent MH - Risk Factors PMC - PMC12642214 OTO - NOTNLM OT - Metabolic-associated fatty liver disease OT - Obesity children OT - Online nomogram OT - Prediction model COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Institutional Review Board of the Children's Hospital Affiliated to Zhengzhou University (Ethics Approval No. 2024-094-001). Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests. EDAT- 2025/11/25 06:27 MHDA- 2025/11/25 06:28 PMCR- 2025/11/24 CRDT- 2025/11/25 03:59 PHST- 2025/04/07 00:00 [received] PHST- 2025/10/20 00:00 [accepted] PHST- 2025/11/25 06:28 [medline] PHST- 2025/11/25 06:27 [pubmed] PHST- 2025/11/25 03:59 [entrez] PHST- 2025/11/24 00:00 [pmc-release] AID - 10.1186/s13052-025-02151-z [pii] AID - 2151 [pii] AID - 10.1186/s13052-025-02151-z [doi] PST - epublish SO - Ital J Pediatr. 2025 Nov 24;51(1):307. doi: 10.1186/s13052-025-02151-z. PMID- 41286970 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251230 LR - 20260101 IS - 2052-1847 (Print) IS - 2052-1847 (Electronic) IS - 2052-1847 (Linking) VI - 17 IP - 1 DP - 2025 Nov 24 TI - The role of therapeutic climbing in child and adolescent mental health: a systematic literature review. PG - 376 LID - 10.1186/s13102-025-01417-7 [doi] LID - 376 AB - BACKGROUND: Therapeutic climbing is increasingly applied as a physical activity intervention targeting mental health in children and adolescents. However, the evidence base regarding its effectiveness and implementation remains fragmented. This systematic review aimed to synthesize current evidence on the effects of therapeutic climbing on mental health and interrelated psychological domains in children and adolescents. METHODS: The review followed PRISMA guidelines and was registered in PROSPERO. Seven electronic databases (Pubmed, PsycINFO, PsycARTICLES, PubPsych, Medline, Web of Science, and CINAHL) were systematically searched for controlled trials investigating therapeutic climbing in children and adolescents, focusing on outcomes on mental health and interrelated domains such as affective and emotional responses, self-efficacy and social dimensions. Study selection, data extraction, and risk of bias assessment were conducted independently by two reviewers. RESULTS: Five controlled trials met the inclusion criteria, including three randomized controlled trials and two non-randomized studies. Significant heterogeneity in study designs, intervention characteristics, and outcome measures limited comparability across studies. Reported benefits included improvements in overall mental health, psychological distress, self-efficacy, alienation, and affective and emotional states. However, reliance on wait-list controls, the absence of active control groups, small sample sizes, and potential expectancy biases complicated the interpretation of findings. Additionally, variability in group sizes, facilitator roles, and intervention settings highlighted the need for standardized protocols to enhance consistency and reliability in future research. CONCLUSIONS: Therapeutic climbing showed promise as a psychologically beneficial intervention for children and adolescents. However, the current evidence base is limited, with few studies and significant variability in study designs, populations, and outcome measures. Notably, it remains unclear whether therapeutic climbing is superior to other physical activity interventions. Future research should address methodological limitations, incorporate active control groups to disentangle climbing-specific effects from general physical and social benefits, and investigate the mechanisms underlying observed effects. Greater emphasis on clinical populations and diverse settings will enhance the evidence base and guide practical applications. TRIAL REGISTRATION: The systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO) (registration number: CRD42024619108). CI - (c) 2025. The Author(s). FAU - Kaar, Carmen AU - Kaar C AUID- ORCID: 0009-0004-9287-2355 AD - Department of Sport Science, University of Innsbruck, Furstenweg 176, Innsbruck, 6020, Austria. carmen.kaar@uibk.ac.at. FAU - Fruhauf, Anika AU - Fruhauf A AUID- ORCID: 0000-0003-1929-390X AD - Department of Sport Science, University of Innsbruck, Furstenweg 176, Innsbruck, 6020, Austria. FAU - Kopp, Martin AU - Kopp M AUID- ORCID: 0000-0002-3011-387X AD - Department of Sport Science, University of Innsbruck, Furstenweg 176, Innsbruck, 6020, Austria. LA - eng PT - Journal Article DEP - 20251124 PL - England TA - BMC Sports Sci Med Rehabil JT - BMC sports science, medicine & rehabilitation JID - 101605016 PMC - PMC12750606 OTO - NOTNLM OT - Bouldering OT - Children and adolescents OT - Climbing OT - Exercise therapy OT - Mental health OT - Physical activity intervention OT - Psychological well-being OT - Youth COIS- Declarations. Ethics approval and consent to participate: No ethics approval was required as only secondary (published) data was used. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/25 06:26 MHDA- 2025/11/25 06:27 PMCR- 2025/11/24 CRDT- 2025/11/25 03:42 PHST- 2025/03/21 00:00 [received] PHST- 2025/10/24 00:00 [accepted] PHST- 2025/11/25 06:27 [medline] PHST- 2025/11/25 06:26 [pubmed] PHST- 2025/11/25 03:42 [entrez] PHST- 2025/11/24 00:00 [pmc-release] AID - 10.1186/s13102-025-01417-7 [pii] AID - 1417 [pii] AID - 10.1186/s13102-025-01417-7 [doi] PST - epublish SO - BMC Sports Sci Med Rehabil. 2025 Nov 24;17(1):376. doi: 10.1186/s13102-025-01417-7. PMID- 41286965 OWN - NLM STAT- MEDLINE DCOM- 20251230 LR - 20260112 IS - 1824-7288 (Electronic) IS - 1720-8424 (Linking) VI - 51 IP - 1 DP - 2025 Nov 24 TI - The association between copeptin and hypertension in children and adolescents: a systematic review. PG - 329 LID - 10.1186/s13052-025-02145-x [doi] LID - 329 AB - Copeptin, a stable surrogate marker of arginine vasopressin, has been implicated in blood pressure regulation, but its role in pediatric hypertension remains unclear. This systematic review evaluates the association between copeptin levels and hypertension in children and adolescents. A comprehensive search was conducted in PubMed, Scopus, Web of Science, Embase, and Cochrane Library up to February 21, 2025. Additional sources, including Google Scholar and reference lists of relevant articles, were screened to ensure literature saturation. Observational studies (cohort, case-control, and cross-sectional) assessing copeptin levels in relation to blood pressure in pediatric populations (< 18 years) were included. Copeptin levels were assessed using validated biochemical methods, including enzyme-linked immunosorbent assay. The Newcastle-Ottawa Scale was used to assess the quality of included studies. Due to heterogeneity in study designs and outcome measurements, a narrative synthesis was performed. Twelve studies met the inclusion criteria, with sample sizes ranging from 25 to 351 participants. Some studies reported a significant association between higher copeptin levels and hypertension, particularly in children with obesity or metabolic disorders. However, other studies found no significant correlation. Differences in study design, sample characteristics, copeptin measurement methods, and confounding factors contributed to the heterogeneity of findings. The evidence on the association between copeptin and hypertension in children is inconclusive. While some studies support its potential role as a biomarker, inconsistencies highlight the need for standardized methodologies and longitudinal studies. Future research should explore copeptin's clinical utility in pediatric hypertension risk stratification.Systematic review registration number PROSPERO: CRD420251003190. CI - (c) 2025. The Author(s). FAU - Mojtahedi, Sayed Yousef AU - Mojtahedi SY AD - Pediatric Chronic Kidney Disease Research Center, Gene, Cell and Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran. AD - Department of Pediatric Nephrology, School of Medicine, Bahrami Hospital, Tehran University Medical Sciences, Tehran, Iran. FAU - Pourpashang, Paniz AU - Pourpashang P AD - Pediatric Chronic Kidney Disease Research Center, Gene, Cell and Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Paaniz.P@gmail.com. AD - Department of Pediatric Nephrology, School of Medicine, Bahrami Hospital, Tehran University Medical Sciences, Tehran, Iran. Paaniz.P@gmail.com. LA - eng PT - Journal Article PT - Systematic Review DEP - 20251124 PL - England TA - Ital J Pediatr JT - Italian journal of pediatrics JID - 101510759 RN - 0 (Glycopeptides) RN - 0 (copeptins) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Glycopeptides/blood MH - Child MH - Adolescent MH - *Hypertension/blood MH - Biomarkers/blood MH - Male MH - Female PMC - PMC12750963 OTO - NOTNLM OT - Adolescents OT - Arginine vasopressin OT - Biomarkers OT - Blood pressure OT - Children OT - Copeptin OT - Hypertension OT - Pediatric hypertension OT - Systematic review COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: There isn't any conflict of interest. EDAT- 2025/11/25 06:27 MHDA- 2025/12/30 07:41 PMCR- 2025/11/24 CRDT- 2025/11/25 03:42 PHST- 2025/07/16 00:00 [received] PHST- 2025/10/11 00:00 [accepted] PHST- 2025/12/30 07:41 [medline] PHST- 2025/11/25 06:27 [pubmed] PHST- 2025/11/25 03:42 [entrez] PHST- 2025/11/24 00:00 [pmc-release] AID - 10.1186/s13052-025-02145-x [pii] AID - 2145 [pii] AID - 10.1186/s13052-025-02145-x [doi] PST - epublish SO - Ital J Pediatr. 2025 Nov 24;51(1):329. doi: 10.1186/s13052-025-02145-x. PMID- 41286889 OWN - NLM STAT- MEDLINE DCOM- 20251230 LR - 20260101 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 24 IP - 1 DP - 2025 Nov 24 TI - Prospective association between dietary source-determined nitrate/nitrite and the risk of metabolic syndrome among children and adolescents: Tehran lipid and glucose study. PG - 193 LID - 10.1186/s12937-025-01239-w [doi] LID - 193 AB - BACKGROUND: Concerning rare evidence on the relationship of dietary nitrate (NO(3))/nitrite (NO(2)) from plant or animal food groups with metabolic syndrome (MetS) in children and adolescents, this study investigates the longitudinal association of total, plant- or animal-sourced dietary NO(2)/NO(3) intake in children and adolescents with the incidence of MetS and its risk factors. METHODS: In this secondary analysis, 1144 children and adolescents (46.2% male) aged 6-19 years were selected from the Tehran Lipid and Glucose Study participants. Dietary data were gathered by a valid and reliable semi-quantitative food frequency questionnaire. A validated national database was used to estimate dietary NO(2)/NO(3) intakes. MetS was defined according to Cook's criteria and the Iranian-modified National Cholesterol Education Program. RESULTS: The mean +/- SD ages of males and females at baseline were 13.1 +/- 3.76 and 14.0 +/- 3.77, respectively. The risk of MetS increased with consuming total nitrite and total nitrate exceeding acceptable dietary intake (ADI); however, this association disappears after adjusting for dietary variables. There were positive significant associations between total NO(2) intake and the incidence of high fasting blood glucose (FBG) in follow-ups [HR (CI) Q4: 1.42(1.13-1.77), P-trend = 0.001]. Also, the HR of high FBG increased across quartiles of animal-based dietary NO(3) and plant-sourced dietary NO(2). The risk of high blood pressure (BP) increased about 5% with consuming every 100 mg of total nitrate exceeding ADI. Exposure to nitrate from animal and plant food groups were positively associated with high BP incidence, while higher intake of plant originated nitrite increased the risk of high BP incidence. Participants with the highest animal-sourced nitrate intake had a 19% higher risk of high triglyceride (TG), compared to the lowest intake. CONCLUSION: Our findings provide evidence that dietary NO(2)/NO(3) intake in children and adolescents whether from the plant or animal food sources were not associated with MetS incidence. High dietary intake of total NO(2) increased the incidence of some MetS risk factors; while high intake of NO(3) in spite of their sources increased the incidence of high BP. Exposure to animal-sourced nitrate intake had increased the risk of high TG. CI - (c) 2025. The Author(s). FAU - Hosseini-Esfahani, Firoozeh AU - Hosseini-Esfahani F AD - Nutrition and Endocrine Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Rafiei, Maryam AU - Rafiei M AD - Nutrition and Endocrine Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Bahadoran, Zahra AU - Bahadoran Z AD - Micronutrient Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Hasheminia, Mitra AU - Hasheminia M AD - Department of Biostatistics and Epidemiology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Mirmiran, Parvin AU - Mirmiran P AD - Nutrition and Endocrine Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. parvin.mirmiran@sbmu.ac.ir. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. parvin.mirmiran@sbmu.ac.ir. FAU - Azizi, Fereidoun AU - Azizi F AD - Endocrine Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. LA - eng GR - 43012295/Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences/ PT - Journal Article DEP - 20251124 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 RN - 0 (Nitrates) RN - 0 (Nitrites) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - *Nitrates/administration & dosage/adverse effects MH - Male MH - *Metabolic Syndrome/epidemiology/blood/etiology MH - Child MH - Female MH - Adolescent MH - Iran/epidemiology MH - Risk Factors MH - *Nitrites/administration & dosage/adverse effects MH - *Diet MH - Prospective Studies MH - Blood Glucose/analysis/metabolism MH - Young Adult MH - Incidence MH - Animals PMC - PMC12751790 OTO - NOTNLM OT - Abdominal obesity OT - Adolescent OT - Children OT - Dysglycemia OT - Dyslipidaemia OT - Metabolic syndrome OT - Nitrate OT - Nitrite COIS- Declarations. Ethics approval and consent to participate: All participants' parents signed an informed consent form before participating in this study. The study was performed according to the Declaration of Helsinki; the study proposal was approved by the Research Institute for Endocrine Sciences ethics committee, Shahid Beheshti University of Medical Sciences (Tehran, Iran) IR.SBMU.ENDOCRINE.REC.1403.118. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/25 06:27 MHDA- 2025/12/30 07:40 PMCR- 2025/11/24 CRDT- 2025/11/25 03:30 PHST- 2025/04/26 00:00 [received] PHST- 2025/10/12 00:00 [accepted] PHST- 2025/12/30 07:40 [medline] PHST- 2025/11/25 06:27 [pubmed] PHST- 2025/11/25 03:30 [entrez] PHST- 2025/11/24 00:00 [pmc-release] AID - 10.1186/s12937-025-01239-w [pii] AID - 1239 [pii] AID - 10.1186/s12937-025-01239-w [doi] PST - epublish SO - Nutr J. 2025 Nov 24;24(1):193. doi: 10.1186/s12937-025-01239-w. PMID- 41285278 OWN - NLM STAT- MEDLINE DCOM- 20260309 LR - 20260309 IS - 1531-5037 (Electronic) IS - 0022-3468 (Linking) VI - 61 IP - 3 DP - 2026 Mar TI - Determining the anal position index in Portuguese newborns: Is it a consistent and reproducible measurement? PG - 162826 LID - S0022-3468(25)00673-6 [pii] LID - 10.1016/j.jpedsurg.2025.162826 [doi] AB - BACKGROUND: The anatomical position of the anus is a critical parameter in neonatal physical assessment due to its association with functional symptoms like constipation and anatomical anomalies such as anorectal malformations (ARM). The Anal Position Index (API) provides an objective and useful method for assessing anal positioning, though normal values for Portuguese newborns remain undocumented. We aimed to determine normal API values in Portuguese full-term newborns and assess interobserver variability. METHODS: This prospective, cross-sectional observational study included 201 healthy, full-term Portuguese newborns. Measurements were obtained using anatomical landmarks extensively described in the literature. API was calculated as the ratio of perineal distances specific to each gender. Interobserver reliability was assessed in a subset of 31 newborns. RESULTS: The mean API was 0.37 +/- 0.08 in females and 0.52 +/- 0.08 in males, significantly higher in this gender (p < 0.001). No significant correlation was found between API and anthropometric parameters. Interobserver reliability demonstrated good agreement (ICC = 0.879, p < 0.001). CONCLUSIONS: Our study defined normal API values for Portuguese newborns, consistent with results from previous investigations. API measurements showed high reliability and reproducibility, making it a simple, non-invasive tool for transversal use in neonatal examination for anomalies of anal positioning. Further multicenter, longitudinal studies are recommended to validate its clinical significance and utility in routine pediatric care. CI - Copyright (c) 2025 Elsevier Inc. All rights reserved. FAU - Trigueiros da Cunha, Luis AU - Trigueiros da Cunha L AD - Instituto Ciencias Biomedicas Abel Salazar, R. de Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal. FAU - Gaspar, Luisa AU - Gaspar L AD - Department of Pediatric Surgery, Unidade Local de Saude de Santo Antonio. Rua da Maternidade, 4050-371, Porto, Portugal. FAU - Carvalho, Carmen AU - Carvalho C AD - Department of Neonatology, Unidade Local de Saude de Santo Antonio. Rua da Maternidade, 4050-371, Porto, Portugal. FAU - Carvalho, Catarina AU - Carvalho C AD - Department of Pediatric Surgery, Unidade Local de Saude de Santo Antonio. Rua da Maternidade, 4050-371, Porto, Portugal. Electronic address: catarinabarbosadecarvalho@gmail.com. LA - eng PT - Journal Article PT - Observational Study DEP - 20251122 PL - United States TA - J Pediatr Surg JT - Journal of pediatric surgery JID - 0052631 SB - IM MH - Humans MH - Male MH - Cross-Sectional Studies MH - *Anal Canal/anatomy & histology MH - Female MH - Infant, Newborn MH - Prospective Studies MH - Portugal MH - Reproducibility of Results MH - Observer Variation MH - Reference Values MH - Perineum/anatomy & histology MH - Anorectal Malformations/diagnosis OTO - NOTNLM OT - Anal position index OT - Anorectal malformation OT - Anterior anus OT - Constipation COIS- Conflicts of interest The authors declare that they have no competing financial interests or personal relationships that could have influenced the work reported in this paper. EDAT- 2025/11/25 00:28 MHDA- 2026/03/09 07:42 CRDT- 2025/11/24 19:13 PHST- 2025/06/15 00:00 [received] PHST- 2025/11/03 00:00 [revised] PHST- 2025/11/15 00:00 [accepted] PHST- 2026/03/09 07:42 [medline] PHST- 2025/11/25 00:28 [pubmed] PHST- 2025/11/24 19:13 [entrez] AID - S0022-3468(25)00673-6 [pii] AID - 10.1016/j.jpedsurg.2025.162826 [doi] PST - ppublish SO - J Pediatr Surg. 2026 Mar;61(3):162826. doi: 10.1016/j.jpedsurg.2025.162826. Epub 2025 Nov 22. PMID- 41284665 OWN - NLM STAT- MEDLINE DCOM- 20251124 LR - 20251127 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 11 DP - 2025 TI - Influence of body mass index on the reliability and validity of ultrasound assessments in adolescent idiopathic scoliosis: An original research. PG - e0335472 LID - 10.1371/journal.pone.0335472 [doi] LID - e0335472 AB - OBJECTIVES: Clinical ultrasound provides a non-invasive method to assess spinal curvature in adolescent idiopathic scoliosis (AIS). However, the reliability and validity of ultrasound assessment may be affected by body mass index (BMI). This study investigated the impact of BMI on the reliability and validity of ultrasound assessments in AIS. DESIGN: 165 participants with suspected AIS were recruited for both ultrasound and radiographic assessments. Lateral spinal curvature was measured on ultrasound imaging using the spinous process method and on X-ray using the Cobb method. The same operator performed two ultrasound scans for each participant, and two independent raters measured the images (Rater 1: 1st and 2nd scans; Rater 2: 1st scan only). Intra-operator and inter-rater reliabilities were assessed using intraclass correlation coefficients (ICCs), and validity was assessed by correlating ultrasound angles with Cobb angles using Pearson's r. Participants were categorized by BMI tertiles and BMI-for-age percentiles for subgroup analyses. RESULTS: The second BMI tertile (16.2-18.5 kg/m2) exhibited the highest reliability: ICC (2,1)=0.83 (95% CI: 0.73-0.90) intra-operator and 0.88 (95% CI: 0.76-0.94) inter-rater. By BMI-for-age classification, the normal-weight group demonstrated the highest reliability (ICC = 0.78 and 0.84) and the lowest standard error of measurement (2.6 degrees and 2.3 degrees ). Validity was strongest in the 18.1-24.4 kg/m2 BMI group (r = 0.85), compared with 12.3-15.8 kg/m2 (r = 0.58) and 16.0-17.7 kg/m2 (r = 0.61). CONCLUSIONS: The reliability of ultrasound assessments of spinal curvature was highest in adolescents in the second BMI tertile and in the normal-weight group, while underweight and overweight groups showed lower reliability. Correlation with Cobb angles was strongest in the 18.1-24.4 kg/m(2) BMI group (r = 0.85), suggesting ultrasound performs best when soft-tissue conditions are neither minimal nor excessive. These findings suggest that BMI should be considered when interpreting ultrasound measurements and when designing screening protocols for AIS. CI - Copyright: (c) 2025 Zou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Zou, JoJo Yiying AU - Zou JY AUID- ORCID: 0000-0003-2153-8742 AD - Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR. FAU - Ho, Shirley Lok Yi AU - Ho SLY AD - Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR. FAU - Beygi, Babak Hassan AU - Beygi BH AUID- ORCID: 0000-0001-8152-9026 AD - Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR. FAU - Luo, Changliang AU - Luo C AD - Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR. AD - School of Rehabilitation, Kunming Medical University, Kunming, China. FAU - Wong, Man Sang AU - Wong MS AD - Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR. LA - eng PT - Journal Article DEP - 20251124 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Scoliosis/diagnostic imaging MH - *Body Mass Index MH - Adolescent MH - Female MH - Ultrasonography MH - Male MH - Reproducibility of Results MH - Child MH - Spine/diagnostic imaging PMC - PMC12643305 COIS- The authors have declared that no competing interests exist. EDAT- 2025/11/24 18:38 MHDA- 2025/11/24 18:39 PMCR- 2025/11/24 CRDT- 2025/11/24 13:36 PHST- 2025/06/18 00:00 [received] PHST- 2025/10/10 00:00 [accepted] PHST- 2025/11/24 18:39 [medline] PHST- 2025/11/24 18:38 [pubmed] PHST- 2025/11/24 13:36 [entrez] PHST- 2025/11/24 00:00 [pmc-release] AID - PONE-D-25-31678 [pii] AID - 10.1371/journal.pone.0335472 [doi] PST - epublish SO - PLoS One. 2025 Nov 24;20(11):e0335472. doi: 10.1371/journal.pone.0335472. eCollection 2025. PMID- 41284618 OWN - NLM STAT- MEDLINE DCOM- 20251124 LR - 20251127 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 11 DP - 2025 TI - Quantification of Anopheles daily sugar feeding rates in Siaya county, western Kenya using Attractive Sugar Baits. PG - e0337207 LID - 10.1371/journal.pone.0337207 [doi] LID - e0337207 AB - BACKGROUND: Vector control is an essential component of malaria prevention that has contributed to the reduction in malaria burden since 2000. Although steady progress in malaria vector control has been achieved over the years, the malaria burden remains substantial, underscoring the need for complementary mosquito control tools to further reduce transmission. Attractive targeted sugar baits (ATSBs) are a novel vector control tool under evaluation. The ATSB paradigm leverages the sugar feeding and resting behavior of mosquitoes exposing them to the lethal effect of an added insecticide. Prior to epidemiological trials on ATSBs in western Kenya, validation studies were conducted to assess the levels of mosquito feeding on attractive sugar baits (ASBs), containing uranine dye. This study sought to understand the ATSB deployment required in peridomestic spaces and to determine the daily feeding rates that would be potentially sufficient to impact malaria transmission (based on modelling approaches). The study evaluated whether the deployment of two versus three bait stations per structure led to higher daily feeding rates by local malaria vectors that is consistent with the modelled threshold of 2.5% of all mosquitoes in the target area as a proxy for ATSB efficacy resulting in a 30% drop in clinical incidence in children under 5. METHODS: The study followed a cross-over design in ten treatment and two control clusters within Rarieda Sub-County, Siaya County, western Kenya. Within each intervention cluster, either two or three ASBs were deployed to all structures in each cluster. After two months, the treatments were switched so that clusters which initially received two ASBs were given three ASBs and vice versa. ASB monitoring was done for four months during the initial crossover trial and then for an additional four months for extended monitoring. Mosquitoes were collected using ultraviolet CDC light traps and Prokopack aspiration indoors and outdoors then identified based on morphological characteristics and screened for fluorescence due to the uranine dye. Molecular species identification was done using polymerase chain reaction and sporozoite infectivity tests by Enzyme-linked immunosorbent assay. Data analysis was performed using R statistical software. RESULTS: The predominant malaria vector was An. funestus sensu lato (s.l.), which had an overall dye feeding rate of 11.2%. This was followed by An. gambiae s.l. at 3.5%. These corresponded to daily feeding rates of 4.8% and 1.2%, respectively. Sporozoite positivity rates were 2.3% (n = 29) in An. funestus s.l and 1.0% (n = 19) in An. gambiae s.l. Higher dye positivity was observed in male An. funestus (OR = 1.22; 95% CI = 1.03,1.46; P = 0.029) and male An. gambiae (OR = 2.20; 95% CI = 1.19,4.08; P = 0.015). Comparison of the impact of 2 versus 3 bait stations indicated no difference in feeding rates in either An. funestus (OR = 0.83; 95% CI = 0.40; 1.75), P = 0.624) or An. gambiae (OR = 1.11; 95% CI = 0.71, 1.71; P = 0.661). CONCLUSIONS: The results from this study showed that predominant malaria vectors; Anopheles funestus led to a daily feeding rate that was presumed to be sufficient to cause a reduction in malaria incidence by ATSBs. There was no significant difference detected between deploying two or three bait stations per structure. The study provided important information utilized in the subsequent deployment of ATSBs in epidemiological trials. CI - Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. FAU - Kosgei, Jackline Jeruto AU - Kosgei JJ AUID- ORCID: 0009-0005-1320-1025 AD - Entomology Section, Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya. AD - Department of Biomedical Sciences and Technology, School of Public Health and Community Development, Maseno University, Maseno, Kenya. FAU - McDermott, Daniel P AU - McDermott DP AD - Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom. FAU - Omondi, Seline AU - Omondi S AD - Entomology Section, Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya. FAU - Moshi, Vincent AU - Moshi V AD - Entomology Section, Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya. FAU - Donnelly, Martin J AU - Donnelly MJ AD - Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom. FAU - Ouma, Collins AU - Ouma C AUID- ORCID: 0000-0001-8205-8887 AD - Department of Biomedical Sciences and Technology, School of Public Health and Community Development, Maseno University, Maseno, Kenya. FAU - Selvaraj, Prashanth AU - Selvaraj P AD - Institute for Disease Modeling, Gates Foundation, Seattle, Washington, United States of America. FAU - Harris, Angela F AU - Harris AF AD - Innovative Vector Control Consortium, Liverpool, United Kingdom. FAU - Entwistle, Julian AU - Entwistle J AD - Innovative Vector Control Consortium, Liverpool, United Kingdom. FAU - Ter Kuile, Feiko O AU - Ter Kuile FO AD - Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom. FAU - Fraser, Keith AU - Fraser K AD - Imperial College London, London, United Kingdom. FAU - Mwandigha, Lazaro AU - Mwandigha L AD - Imperial College London, London, United Kingdom. FAU - Abong'o, Bernard AU - Abong'o B AD - Entomology Section, Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya. FAU - Gimnig, John E AU - Gimnig JE AUID- ORCID: 0000-0003-4218-447X AD - Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America. FAU - Ochomo, Eric AU - Ochomo E AUID- ORCID: 0000-0002-4042-4970 AD - Entomology Section, Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya. AD - Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom. LA - eng PT - Journal Article DEP - 20251124 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Sugars) RN - 0 (Insecticides) SB - IM MH - Kenya/epidemiology MH - *Anopheles/physiology/parasitology MH - Animals MH - *Mosquito Control/methods MH - *Feeding Behavior MH - *Mosquito Vectors/physiology MH - *Malaria/prevention & control/transmission/epidemiology MH - *Sugars MH - Humans MH - Insecticides/pharmacology MH - Female PMC - PMC12643295 COIS- The authors have declared that no competing interests exist. EDAT- 2025/11/24 18:38 MHDA- 2025/11/24 18:39 PMCR- 2025/11/24 CRDT- 2025/11/24 13:26 PHST- 2025/06/05 00:00 [received] PHST- 2025/11/04 00:00 [accepted] PHST- 2025/11/24 18:39 [medline] PHST- 2025/11/24 18:38 [pubmed] PHST- 2025/11/24 13:26 [entrez] PHST- 2025/11/24 00:00 [pmc-release] AID - PONE-D-25-29347 [pii] AID - 10.1371/journal.pone.0337207 [doi] PST - epublish SO - PLoS One. 2025 Nov 24;20(11):e0337207. doi: 10.1371/journal.pone.0337207. eCollection 2025. PMID- 41283207 OWN - NLM STAT- MEDLINE DCOM- 20260402 LR - 20260406 IS - 1936-7163 (Electronic) IS - 0033-6572 (Linking) VI - 57 IP - 3 DP - 2026 Apr 2 TI - Feasibility of two-color chewing gum mixing ability test for evaluating masticatory performance in schoolchildren. PG - 218-228 LID - 10.3290/j.qi.b6689083 [doi] AB - OBJECTIVE: Mastication plays a major role in a person's life and affects much of their quality of life, from enjoying food to facilitating nutrition. This study aimed to assess the feasibility of evaluating masticatory performance in schoolchildren during routine dental exams using a validated chewing test. METHOD AND MATERIALS: Adolescents aged 11 to 19 from schools in Greifswald, Germany, were recruited. From a population exceeding 3,000, a 40% response rate was expected. A randomization list determined whether consenting participants underwent testing, limited to 50% to avoid selection bias. Data collected included age, sex, and school type. Masticatory performance was assessed using the two-color chewing gum test (Hue-Check Gum), evaluated visually (subjective assessment scale, 1 to 5) and digitally (Viewgum variance of hue, 0 to 1). RESULTS: In total, 861 participants were recruited (mean age 13.85 +/- 2.02 years; 48.55% female). Low masticatory performance (subjective assessment scale 1 or 2) was observed in 14.59% of participants, indicating potential chewing difficulties impacting daily life. Masticatory performance improved with age, reflected by a decrease in the variance of hue value from 0.3 in 11-year-olds to 0.21 in 18- to 19-year-olds. Masticatory performance did not differ significantly between sexes: median subjective assessment scale score 3 (interquartile range 3-4; P = .517). Participants with permanent dentition showed higher masticatory performance than those with mixed dentition: (3 [3-4] vs 3 [3-3]; P .001). CONCLUSION: This study confirms that masticatory performance increases with age. Routine implementation of masticatory performance testing during school dental screenings is feasible and may help identify children at risk of impaired chewing function. (Quintessence Int 2026;57:218-228; doi: 10.3290/j.qi.b6689083). FAU - Mourad, Mhd Said AU - Mourad MS FAU - Splieth, Christian H AU - Splieth CH FAU - Pink, Christiane AU - Pink C FAU - Krey, Karl-Friedrich AU - Krey KF FAU - Younus, Shereen AU - Younus S FAU - Schwahn, Christian AU - Schwahn C FAU - Al Masri, Ahmad AU - Al Masri A LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Germany TA - Quintessence Int JT - Quintessence international (Berlin, Germany : 1985) JID - 0342677 RN - 0 (Chewing Gum) SB - IM MH - Humans MH - *Mastication/physiology MH - *Chewing Gum MH - Male MH - Female MH - Child MH - Feasibility Studies MH - Adolescent MH - Young Adult MH - Germany MH - Color OTO - NOTNLM OT - adolescent OT - chewing gum OT - computer-assisted OT - dental examination OT - image processing OT - mastication OT - observer variation EDAT- 2025/11/24 12:39 MHDA- 2026/04/02 12:36 CRDT- 2025/11/24 09:20 PHST- 2026/04/02 12:36 [medline] PHST- 2025/11/24 12:39 [pubmed] PHST- 2025/11/24 09:20 [entrez] AID - 6689083 [pii] AID - 10.3290/j.qi.b6689083 [doi] PST - ppublish SO - Quintessence Int. 2026 Apr 2;57(3):218-228. doi: 10.3290/j.qi.b6689083. PMID- 41282521 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251124 LR - 20251126 IS - 2234-8646 (Print) IS - 2234-8840 (Electronic) IS - 2234-8840 (Linking) VI - 28 IP - 6 DP - 2025 Nov TI - Screening Tools for Malnutrition in Hospitalized Children with Respiratory Tract Infections: A Single Center Experience in a Low/Middle Income Country. PG - 370-380 LID - 10.5223/pghn.2025.28.6.370 [doi] AB - PURPOSE: Detecting the risk of malnutrition in pediatric patients using simple, rapid, and validated screening tools is important. The most frequently used screening tools are the Screening Tool for the Assessment of Malnutrition in Pediatrics (STAMP), Pediatric Yorkhill Malnutrition Score (PYMS), and Screening Tool for Risk on Nutritional Status and Growth (STRONG-kids). We aimed to assess the value of STAMP as a nutritional screening tool for the evaluation of nutritional status compared to other tools in children with respiratory tract infections (RTIs) admitted to a single tertiary referral hospital in a low/middle-income country. METHODS: This cross-sectional study enrolled 80 children aged 1-12 years who were admitted for RTIs. Each participant was evaluated anthropometrically, and three screening tools (STAMP, PYMS, and STRONG-kids) were used. RESULTS: Anthropometric measurements showed that 65% of the patients were stunted, 77.5% were underweight, and 60% were wasted. The STAMP score showed the most sensitivity (91.9%) and specificity (77.8%) in predicting malnutrition compared to weight-for-age, while STRONG-kids showed a sensitivity of 85.5% and specificity of 50%. Similarly, the STAMP score showed the most sensitivity (88.7%) and specificity (77.8%) in predicting malnutrition compared to height-for-age, while STRONG-kids showed a sensitivity of 81.8% and specificity of 29.6%. CONCLUSION: The STAMP is a reliable screening tool for malnutrition in children admitted for RTIs. In addition, STRONG-kids is a simple and quick nutritional screening tool for hospitalized children, and it predicts nutritional status on admission. CI - Copyright (c) 2025 by The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition. FAU - Sayed, Shaimaa AU - Sayed S AUID- ORCID: 0000-0002-9009-165X AD - Pediatrics Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt. FAU - Abdallah, Enas A A AU - Abdallah EAA AUID- ORCID: 0000-0002-1714-8816 AD - Pediatrics Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt. FAU - El Koofy, Nehal AU - El Koofy N AUID- ORCID: 0000-0002-7464-6715 AD - Pediatrics Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt. FAU - Yosry, Salma M AU - Yosry SM AUID- ORCID: 0009-0007-3869-3585 AD - Department of Pediatrics, Banha Specialized Hospital, Banha, Egypt. FAU - El-Shabrawi, Mortada H F AU - El-Shabrawi MHF AUID- ORCID: 0000-0002-1995-4213 AD - Pediatrics Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt. FAU - Mansour, Hala H AU - Mansour HH AUID- ORCID: 0000-0002-6394-7694 AD - Pediatrics Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt. LA - eng PT - Journal Article DEP - 20251106 PL - Korea (South) TA - Pediatr Gastroenterol Hepatol Nutr JT - Pediatric gastroenterology, hepatology & nutrition JID - 101590471 PMC - PMC12636106 OTO - NOTNLM OT - Malnutrition OT - Nutritional assessment OT - Pediatric Yorkhill Malnutrition Score OT - Pediatrics OT - Screening Tool for Risk on Nutritional Status and Growth OT - Screening Tool for the Assessment of Malnutrition in Pediatrics COIS- Conflict of Interest: The authors have no financial conflicts of interest. EDAT- 2025/11/24 12:39 MHDA- 2025/11/24 12:40 PMCR- 2025/11/01 CRDT- 2025/11/24 09:14 PHST- 2024/11/10 00:00 [received] PHST- 2025/07/03 00:00 [accepted] PHST- 2025/11/24 12:40 [medline] PHST- 2025/11/24 12:39 [pubmed] PHST- 2025/11/24 09:14 [entrez] PHST- 2025/11/01 00:00 [pmc-release] AID - 10.5223/pghn.2025.28.6.370 [doi] PST - ppublish SO - Pediatr Gastroenterol Hepatol Nutr. 2025 Nov;28(6):370-380. doi: 10.5223/pghn.2025.28.6.370. Epub 2025 Nov 6. PMID- 41282282 OWN - NLM STAT- MEDLINE DCOM- 20251124 LR - 20251126 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 16 DP - 2025 TI - Reference values and biological factors influencing skin autofluorescence. PG - 1700892 LID - 10.3389/fendo.2025.1700892 [doi] LID - 1700892 AB - INTRODUCTION: Tissue glycation, measured as skin autofluorescence (SAF) with an AGE Reader, has been associated with incident type 2 diabetes (T2D), cardiovascular disease (CVD), and CVD and cancer mortality. Validated reference intervals in healthy individuals are needed to make useful and precise risk estimations. METHODOLOGY: This study utilises data from 82,870 participants of Western European descent in the Lifelines Cohort Study, a population-based study in the Netherlands. Reference values for SAF were established in healthy participants. Decade-specific mean SAF values were evaluated for former and current smokers, T2D, CVD, and impaired renal function. We also assessed the association of regular physical activity (PA) with SAF scores. RESULTS: Reference values for healthy individuals were established in 8,179 men and 7,930 women between 18 and 70 years, who had never smoked, had a BMI below 35 kg/m(2), and did not meet the metabolic syndrome criteria. Linear regression analyses yielded the following prediction for SAF, separately by sex: in males, SAF predicted = (0.0191 x age) + 1.038, and in females, SAF predicted = (0.0188 x age) + 0.994. Current smokers had consistently higher SAF scores. There was a progressively higher SAF with a higher number of pack-years of smoking in each age decade, in both sexes. For each decade, both people with T2D and CVD had significantly higher SAF values compared to healthy individuals. The same applied to participants with impaired renal function. There was a complex non-linear relationship between PA and age-adjusted SAF score: mean SAF was the highest in sedentary participants (e.g., 0 min/week moderate-to-vigorous physical activity), lowest in those with 150-299 min/week PA, and gradually increasing in participants with higher than 600 min/week PA. CONCLUSIONS: We provide robust reference values for SAF, established in healthy individuals of Western European descent, separately by sex, who have never smoked. Higher levels of SAF are observed in former and current smokers and in people with T2D, CVD, and impaired renal function. The relationship between physical activity and SAF scores is complex, with higher SAF scores demonstrated in sedentary people and those performing a large amount of moderate-to-vigorous physical exercise. CI - Copyright (c) 2025 Wolffenbuttel, Boersma, van Waateringe, Paterson and van der Klauw. FAU - Wolffenbuttel, Bruce H R AU - Wolffenbuttel BHR AD - Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands. FAU - Boersma, Henderikus E AU - Boersma HE AD - Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands. AD - Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands. FAU - van Waateringe, Robert AU - van Waateringe R AD - Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands. FAU - Paterson, Andrew D AU - Paterson AD AD - Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, ON, Canada. AD - Divisions of Biostatistics and Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. FAU - van der Klauw, Melanie M AU - van der Klauw MM AD - Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands. LA - eng PT - Journal Article DEP - 20251106 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - Male MH - Female MH - Middle Aged MH - Adult MH - Reference Values MH - *Skin/metabolism MH - Aged MH - Young Adult MH - Adolescent MH - Cardiovascular Diseases/metabolism/epidemiology MH - Netherlands/epidemiology MH - *Diabetes Mellitus, Type 2/metabolism/epidemiology MH - Smoking MH - Exercise/physiology MH - Cohort Studies MH - *Optical Imaging PMC - PMC12631760 OTO - NOTNLM OT - advanced glycation end-products OT - cardiovascular disease OT - diabetes mellitus OT - physical activity OT - reference values OT - renal dysfunction OT - skin autofluorescence OT - smoking COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/11/24 12:38 MHDA- 2025/11/24 18:38 PMCR- 2025/11/06 CRDT- 2025/11/24 09:11 PHST- 2025/09/07 00:00 [received] PHST- 2025/10/06 00:00 [accepted] PHST- 2025/11/24 18:38 [medline] PHST- 2025/11/24 12:38 [pubmed] PHST- 2025/11/24 09:11 [entrez] PHST- 2025/11/06 00:00 [pmc-release] AID - 10.3389/fendo.2025.1700892 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2025 Nov 6;16:1700892. doi: 10.3389/fendo.2025.1700892. eCollection 2025. PMID- 41281022 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251124 LR - 20251126 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 17 IP - 10 DP - 2025 Oct TI - Changes in Health-Related Behaviours Among Adults Who Accessed Real-World Weight Management Support: 12-Month Outcomes. PG - e95035 LID - 10.7759/cureus.95035 [doi] LID - e95035 AB - Background Large weight losses are desirable, but their benefits are short-lived without sustained behaviour changes that can be maintained at the household level. This longitudinal study, conducted in a real-life setting, investigated changes in weight, dietary habits, activity levels, and physical and mental well-being of members of a community weight management programme (Slimming World), compared with a matched cross-sectional reference group from the general population. The wider influence on the dietary and activity habits of family members was also explored. Methods Longitudinal data were collected from members at 0-4 weeks (T1), 3 months (T2), and 12 months (T4) after joining. The reference group completed surveys at each time point. Diet quality scores (NDQS) were calculated using a validated tool, hours of moderate-intensity physical activity were recorded, and mental well-being was assessed using adapted items from the SF Health Survey. Changes in members' behaviours and comparisons with the reference group were analysed using within- and between-group ANOVAs with p-adjusted post-hoc comparisons. Results Of the 1,884 members who provided baseline data, 174 (7.5% male) completed surveys at T1, T2, and T4. At baseline, mean BMI and age were 34.7 +/- 7.0 kg/m(2) and 53.0 +/- 12.0 years, respectively. Mean weight change at 12 months was -7.5%. Member NDQS increased from baseline to T1 (11.5 +/- 3.2 vs 14.1 +/- 2.4, p < 0.001), T2 (14.3 +/- 2.7), and T4 (14.1 +/- 2.9) (both p < 0.05). Physical activity increased between T1 and T2 (4.6 +/- 7.4 vs 6.7 +/- 10.1 hours/week, p < 0.01) and was maintained at T4 (6.5 +/- 6.0, p < 0.05). At T1, T2, and T4, members had higher NDQS, greater levels of physical activity (p < 0.001), and higher mental well-being scores (p < 0.05) than the reference group. At T2, of the 122 members living with a partner, 79.5% reported influencing their partner to eat healthier meals. Among the 47 members living with children, 66.0% reported influencing them to eat healthier meals. The positive influence on partners' and children's eating behaviours observed at T2 remained stable at T4 (both p > 0.05). At T2, 40.7% of members reported encouraging others in their household to become more active, and this proportion remained consistent at T4 (40.5%, p > 0.05). Conclusion Although the low response rate across all three surveys is a limitation, the findings suggest that Slimming World's behaviour change programme is effective in supporting adults (mainly females) living with obesity to make health-related behaviour changes. Members achieved clinically significant weight loss and improvements in diet quality, physical activity, and mental well-being compared with the reference group. These changes were maintained at 12 months, with an additional positive influence reported on family members' lifestyle habits. CI - Copyright (c) 2025, Kent et al. FAU - Kent, Jennifer AU - Kent J AD - Nutrition, Research and Health Policy, Slimming World, Derby, GBR. FAU - Toon, Josef AU - Toon J AD - Division of Psychology, De Montfort University, Leicester, GBR. FAU - Bennett, Sarah-Elizabeth AU - Bennett SE AD - Nutrition, Research and Health Policy, Slimming World, Derby, GBR. FAU - Holloway, Laura AU - Holloway L AD - Nutrition, Research and Health Policy, Slimming World, Derby, GBR. FAU - Pallister, Carolyn AU - Pallister C AD - Nutrition, Research and Health Policy, Slimming World, Derby, GBR. FAU - Lavin, Jacquie AU - Lavin J AD - Nutrition, Research and Health Policy, Slimming World, Derby, GBR. FAU - Donovan, Jemma AU - Donovan J AD - Nutrition, Research and Health Policy, Slimming World, Derby, GBR. FAU - Avery, Amanda AU - Avery A AD - Division of Food, Nutrition and Dietetics, University of Nottingham, Nottingham, GBR. AD - Nutrition, Research and Health Policy, Slimming World, Derby, GBR. LA - eng PT - Journal Article DEP - 20251021 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC12631489 OTO - NOTNLM OT - behaviour change OT - diet quality OT - healthy lifestyle intervention OT - obesity OT - weight management COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. University of Nottingham, School of Biosciences Ethics Committee issued approval No: SB1819/36. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2025/11/24 12:39 MHDA- 2025/11/24 12:40 PMCR- 2025/10/21 CRDT- 2025/11/24 09:01 PHST- 2025/10/20 00:00 [accepted] PHST- 2025/11/24 12:40 [medline] PHST- 2025/11/24 12:39 [pubmed] PHST- 2025/11/24 09:01 [entrez] PHST- 2025/10/21 00:00 [pmc-release] AID - 10.7759/cureus.95035 [doi] PST - epublish SO - Cureus. 2025 Oct 21;17(10):e95035. doi: 10.7759/cureus.95035. eCollection 2025 Oct. PMID- 41277616 OWN - NLM STAT- MEDLINE DCOM- 20260114 LR - 20260914 IS - 1778-3585 (Electronic) IS - 0924-9338 (Print) IS - 0924-9338 (Linking) VI - 69 IP - 1 DP - 2025 Nov 24 TI - The effects of neuromodulation interventions on the eating behaviors of patients with eating disorders compared to healthy controls, sham therapies, and other therapeutic approaches: A systematic review. PG - e5 LID - 10.1192/j.eurpsy.2025.10140 [doi] LID - e5 AB - BACKGROUND: Standard treatments for eating disorders (EDs) typically include nutritional rehabilitation, psychotherapy, and pharmacotherapy, often resulting in modest effectiveness. Neuromodulation has been proposed as a potential add-on strategy. This review aims to critically evaluate its effects on EDs. METHODS: The PICO framework was used to conduct a search according to the PRISMA guidelines for systematic reviews (PROSPERO Registration no. CRD42024559700). Descriptive and clinical data for each study, including comorbidity and safety, were tabulated by disorder. Quality assessment was performed using the RoB2 and ROBINS-I tools. RESULTS: Fifty-eight studies examining rTMS, tDCS, DBS, ECT, iTBS, and dTMS in AN, BN, and BED met inclusion criteria. In AN, the effects of rTMS and tDCS on weight and BMI were modest, with notable benefits for adolescents. Conversely, in refractory AN, DBS produced significant and lasting increases in BMI and reductions in comorbid psychopathology. For BN, single-session rTMS reduced cravings acutely, while multisession results were mixed; tDCS enhanced self-control. In BED, right-DLPFC tDCS decreased cravings, food intake, and binge frequency, showing a dose-dependent effect, whereas early data on NAcc DBS were promising but limited. CONCLUSIONS: Noninvasive stimulation methods effectively reduced cravings and impulsivity, showing more consistent improvements in BN and BED than in weight restoration for AN. Overall, this pattern replicates recent review reports. However, variations in study designs, stimulation protocols, and outcome measures may undermine the reliability of these conclusions and complicate comparisons across studies. Future studies should be adequately powered, multisession, with durability endpoints, and target and dose refinement. FAU - Tsapakis, Evangelia AU - Tsapakis E AUID- ORCID: 0000-0002-2649-6732 AD - 3rd Department of Psychiatry, https://ror.org/02j61yw88Aristotle University of Thessaloniki, Greece. FAU - Karakosta, Efi AU - Karakosta E AUID- ORCID: 0009-0004-2897-8243 AD - 3rd Department of Psychiatry, https://ror.org/02j61yw88Aristotle University of Thessaloniki, Greece. FAU - Karapatis, Apostolos AU - Karapatis A AUID- ORCID: 0009-0009-6794-9409 AD - 3rd Department of Psychiatry, https://ror.org/02j61yw88Aristotle University of Thessaloniki, Greece. FAU - Papazoglou, Anysia AU - Papazoglou A AD - 3rd Department of Psychiatry, https://ror.org/02j61yw88Aristotle University of Thessaloniki, Greece. FAU - Treiber, Michael AU - Treiber M AUID- ORCID: 0000-0003-2192-0810 AD - 3rd Department of Psychiatry, https://ror.org/02j61yw88Aristotle University of Thessaloniki, Greece. AD - https://ror.org/05n3x4p02Medizinische Universitat Wien, Austria. FAU - Fountoulakis, Konstantinos N AU - Fountoulakis KN AUID- ORCID: 0000-0001-5503-0811 AD - 3rd Department of Psychiatry, https://ror.org/02j61yw88Aristotle University of Thessaloniki, Greece. LA - eng PT - Journal Article PT - Systematic Review DEP - 20251124 PL - England TA - Eur Psychiatry JT - European psychiatry : the journal of the Association of European Psychiatrists JID - 9111820 SB - IM MH - Humans MH - *Feeding and Eating Disorders/therapy MH - *Feeding Behavior/physiology MH - *Transcranial Magnetic Stimulation MH - *Transcranial Direct Current Stimulation MH - *Deep Brain Stimulation PMC - PMC12816940 OTO - NOTNLM OT - anorexia nervosa OT - binge eating disorder OT - bulimia nervosa OT - deep brain stimulation OT - eating disorders OT - electroconvulsive treatment OT - neuromodulation OT - repetitive transcranial magnetic stimulation OT - transcranial direct current stimulation COIS- The authors declare none. EDAT- 2025/11/24 12:39 MHDA- 2026/01/14 07:05 PMCR- 2025/11/24 CRDT- 2025/11/24 06:33 PHST- 2026/01/14 07:05 [medline] PHST- 2025/11/24 12:39 [pubmed] PHST- 2025/11/24 06:33 [entrez] PHST- 2025/11/24 00:00 [pmc-release] AID - S0924933825101405 [pii] AID - 10.1192/j.eurpsy.2025.10140 [doi] PST - epublish SO - Eur Psychiatry. 2025 Nov 24;69(1):e5. doi: 10.1192/j.eurpsy.2025.10140. PMID- 41277284 OWN - NLM STAT- MEDLINE DCOM- 20260407 LR - 20260407 IS - 1550-9613 (Electronic) IS - 0278-4297 (Linking) VI - 45 IP - 5 DP - 2026 May TI - Bedside Ultrasound Assessment to Detect Muscle Loss in Critically Ill Children. PG - 977-984 LID - 10.1002/jum.70133 [doi] AB - OBJECTIVES: To evaluate the feasibility and inter-rater reliability of bedside muscle ultrasonography for detecting muscle loss in critically ill pediatric patients. DESIGN: A single-center prospective cohort study was conducted (January 2024-January 2025). METHODS: Critically ill children frequently experience rapid muscle loss, a complication associated with intensive care unit (ICU)-acquired weakness, prolonged mechanical ventilation, and increased morbidity. Early detection of muscle wasting may enable targeted interventions to mitigate these adverse outcomes. PATIENTS: Critically ill children (aged 2-18 years) requiring invasive mechanical ventilation for >24 hours. INTERVENTIONS: Serial ultrasound assessments of the quadriceps femoris muscle thickness and cross-sectional area were performed at baseline and during ICU stay. Potential risk factors (eg, corticosteroid use, neuromuscular blockade, hyperglycemia, and nutritional status) were recorded. RESULTS: Of the 35 patients enrolled in the study, 14 (40%) had significant muscle loss (defined as loss of >/=10% of muscle mass compared to the baseline assessment) detected by decreased muscle thickness, and 20 (57%) had muscle loss detected by reduced cross-sectional area. Muscle loss occurred 3-10 days into their critical illness and invasive mechanical ventilation. Stepwise multivariable logistic associations showed that patients with a lower ratio of actual-to-goal protein intake at the time of scan had higher odds of muscle loss, as it was associated with >10% decrease in cross-sectional area (adjusted OR 3.2, CI 1.22, 3.56) and that a higher mean level of C-reactive protein was associated with a significant decrease in muscle thickness (adjusted OR 1.7, CI 1.23, 3.34). CONCLUSION: Bedside muscle ultrasonography is a feasible, and practical tool for early detection of muscle loss in critically ill children. Its noninvasive nature, portability, and cost-effectiveness support its potential integration into routine ICU monitoring to guide early rehabilitative or nutritional interventions. Further multicenter studies are warranted to validate these findings. CI - (c) 2025 American Institute of Ultrasound in Medicine. FAU - Sabobeh, Mohammad AU - Sabobeh M AUID- ORCID: 0009-0003-8232-6513 AD - Department of Pediatrics Critical Care Medicine, The University of Tennessee Health and Science Center, Memphis, Tennessee, USA. AD - Department of Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. AD - Department of Pediatrics Critical Care Medicine, The University of South Alabama Women and Children's Hospital, Mobile, Alabama, USA. FAU - Seewer, Elizabeth AU - Seewer E AUID- ORCID: 0000-0003-3112-8739 AD - Department of Pediatrics Critical Care Medicine, The University of Tennessee Health and Science Center, Memphis, Tennessee, USA. FAU - Chiriboga, Nicolas AU - Chiriboga N AUID- ORCID: 0009-0003-3004-8486 AD - Department of Pediatrics Critical Care Medicine, The University of Tennessee Health and Science Center, Memphis, Tennessee, USA. FAU - Spentzas, Thomas AU - Spentzas T AUID- ORCID: 0000-0002-9031-645X AD - Department of Pediatrics Critical Care Medicine, The University of Tennessee Health and Science Center, Memphis, Tennessee, USA. FAU - Popat, Shyam AU - Popat S AD - Department of Pediatrics Critical Care Medicine, The University of Tennessee Health and Science Center, Memphis, Tennessee, USA. FAU - Clark, Alyssa AU - Clark A AD - Department of Pediatrics Critical Care Medicine, The University of Tennessee Health and Science Center, Memphis, Tennessee, USA. FAU - Kantor, David B AU - Kantor DB AD - Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Ghafoor, Saad AU - Ghafoor S AD - Department of Pediatrics Critical Care Medicine, The University of Tennessee Health and Science Center, Memphis, Tennessee, USA. AD - Department of Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. LA - eng GR - Health Science Center, University of Tennessee/ PT - Journal Article DEP - 20251124 PL - England TA - J Ultrasound Med JT - Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine JID - 8211547 SB - IM MH - Humans MH - *Critical Illness MH - Child MH - Ultrasonography/methods MH - Male MH - Female MH - Adolescent MH - Child, Preschool MH - Prospective Studies MH - Reproducibility of Results MH - Feasibility Studies MH - *Point-of-Care Testing MH - Respiration, Artificial/adverse effects MH - *Quadriceps Muscle/diagnostic imaging MH - *Point-of-Care Systems OTO - NOTNLM OT - children OT - muscle loss OT - ultrasound EDAT- 2025/11/24 06:27 MHDA- 2026/04/07 06:31 CRDT- 2025/11/24 03:53 PHST- 2025/10/22 00:00 [revised] PHST- 2025/09/04 00:00 [received] PHST- 2025/11/12 00:00 [accepted] PHST- 2026/04/07 06:31 [medline] PHST- 2025/11/24 06:27 [pubmed] PHST- 2025/11/24 03:53 [entrez] AID - 10.1002/jum.70133 [doi] PST - ppublish SO - J Ultrasound Med. 2026 May;45(5):977-984. doi: 10.1002/jum.70133. Epub 2025 Nov 24. PMID- 41276862 OWN - NLM STAT- MEDLINE DCOM- 20251213 LR - 20260328 IS - 2072-1315 (Electronic) IS - 1606-0997 (Print) IS - 1606-0997 (Linking) VI - 44 IP - 1 DP - 2025 Nov 23 TI - Dietary antioxidant capacity, flavonoid subclasses, and metabolic dysfunction-associated fatty liver disease in overweight and obese youth. PG - 420 LID - 10.1186/s41043-025-01155-z [doi] LID - 420 AB - BACKGROUND: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a growing public health concern among children and adolescents with overweight and obesity. Diet quality, particularly antioxidant intake, may play a role in hepatic metabolic regulation. This study investigated the association between dietary total antioxidant capacity (DTAC) and MAFLD, and examined the mediating role of flavonoid subclasses. METHODS: In this cross-sectional study, 505 overweight and obese Iranian children and adolescents aged 7-18 years were recruited. DTAC was estimated using a validated 147-item food frequency questionnaire and the ferric reducing antioxidant power (FRAP) method. MAFLD was diagnosed via ultrasonographic evidence of hepatic steatosis in combination with overweight/obesity. Logistic regression and restricted cubic spline models assessed associations, and mediation analysis evaluated indirect effects of flavonoids. RESULTS: The mean DTAC was 8.7 +/- 3.8 overall, 8.3 +/- 3.3 in the MAFLD group, and 9.0 +/- 4.1 in the non-MAFLD group. In fully adjusted model, participants in the highest DTAC tertile had 62% reduced odds of MAFLD compared to the lowest tertile (OR: 0.38; 95% CI: 0.18-0.82; P-trend = 0.03). Spline analysis confirmed a non-linear inverse association. Mediation analysis revealed that flavonols and anthocyanidins significantly mediated the DTAC-MAFLD relationship, accounting for 74.4% and 38.4% of the total effect, respectively. CONCLUSION: Higher dietary antioxidant capacity is inversely associated with MAFLD in overweight and obese youth, partly through the intake of specific flavonoid subclasses. These findings emphasize the value of antioxidant-rich diets for pediatric liver health and highlight the need for longitudinal studies or clinical trials to confirm causal relationships. CI - (c) 2025. The Author(s). FAU - Kamrani, Farzam AU - Kamrani F AD - Faculty of Medicine, Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Nikparast, Ali AU - Nikparast A AD - Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition & Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Etesami, Elahe AU - Etesami E AD - Department of Nutrition, SR.C., Islamic Azad University, Tehran, Iran. FAU - Sohouli, MohammadHassan AU - Sohouli M AD - Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. FAU - Rohani, Pejman AU - Rohani P AD - Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. rohanipejmanmd@gmail.com. FAU - Asghari, Golaleh AU - Asghari G AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. g_asghari@hotmail.com. LA - eng PT - Journal Article DEP - 20251123 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 RN - 0 (Antioxidants) RN - 0 (Flavonoids) SB - IM MH - Humans MH - Child MH - Adolescent MH - *Antioxidants/administration & dosage MH - Male MH - Female MH - Cross-Sectional Studies MH - *Flavonoids/administration & dosage MH - *Pediatric Obesity/complications/epidemiology MH - *Diet MH - Iran/epidemiology MH - *Non-alcoholic Fatty Liver Disease/epidemiology/prevention & control/etiology MH - *Overweight/complications MH - *Fatty Liver/epidemiology/etiology PMC - PMC12701603 OTO - NOTNLM OT - DTAC OT - Dietary total antioxidant capacity OT - Flavonoid subclasses OT - MAFLD OT - Metabolic dysfunction-associated fatty liver disease COIS- Declarations. Ethical approval and consent to participate: National nutrition and Food Technology Research Institute (NNFTRI) ethics committee approved the study protocol (IR.SBMU.NNFTRI.REC.1402.015). All participants provided written informed consent and were informed about the study. All procedures performed in studies involving human participants adhered to the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/24 00:49 MHDA- 2025/12/13 06:29 PMCR- 2025/11/23 CRDT- 2025/11/23 23:36 PHST- 2025/08/20 00:00 [received] PHST- 2025/11/03 00:00 [accepted] PHST- 2025/12/13 06:29 [medline] PHST- 2025/11/24 00:49 [pubmed] PHST- 2025/11/23 23:36 [entrez] PHST- 2025/11/23 00:00 [pmc-release] AID - 10.1186/s41043-025-01155-z [pii] AID - 1155 [pii] AID - 10.1186/s41043-025-01155-z [doi] PST - epublish SO - J Health Popul Nutr. 2025 Nov 23;44(1):420. doi: 10.1186/s41043-025-01155-z. PMID- 41276701 OWN - NLM STAT- MEDLINE DCOM- 20260109 LR - 20261009 IS - 1476-5640 (Electronic) IS - 0954-3007 (Linking) VI - 80 IP - 1 DP - 2026 Jan TI - Risk factors, clinical outcomes, and the development of a pragmatic zinc deficiency screening tool in patients with cirrhosis: a prospective cohort study. PG - 113-120 LID - 10.1038/s41430-025-01684-0 [doi] AB - BACKGROUND/OBJECTIVES: Zinc plays a crucial role in cirrhosis. Recent American College of Gastroenterology (ACG) guidelines recommend zinc supplementation for patients with cirrhosis and hypozincemia. However, standardized screening protocols remain unavailable, and routine serum zinc evaluation may not be cost-effective or appropriate. This study aims to determine the prevalence, risk factors, and clinical impact of zinc deficiency while developing a standardized tool for its evaluation. SUBJECTS/METHODS: This prospective study included 110 patients with cirrhosis attending outpatient clinics. Serum zinc levels were measured, and data on demographics, cirrhosis severity, complications, and nutritional status were collected. Participants were monitored over a 6-month period to evaluate clinical outcomes. RESULTS: Zinc deficiency was observed in 60% of patients and linked to new/worsening ascites (hazard ratio (HR) 2.8; 95%confidence interval (CI): 1.6-14.1; p = 0.021). Independent risk factors included female gender, non-hepatitis B/C cirrhosis, Child-Pugh B/C, and serum albumin <3.5 g/dL. A novel predictive tool, the Zinc-FANC score, was developed with the following criteria: Female gender (1 point), Albumin <3.5 g/dL (2 points), Non-hepatitis B/C (1 point), and Child-Pugh B/C (1 point). The score categorized patients into low-risk (score 0), medium-risk (scores 1-2), and high-risk (scores 3-5) groups. The high-risk group showed a specificity of 97.7%, while the low-risk group demonstrated a sensitivity of 95.5%. CONCLUSION: Zinc deficiency was common and linked to adverse outcomes. The Zinc-FANC score demonstrates potential utility in guiding zinc screening protocols in patients with cirrhosis; however, external validation in diverse clinical settings is warranted before its implementation in routine practice. CI - (c) 2025. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Lakananurak, Narisorn AU - Lakananurak N AUID- ORCID: 0000-0003-3166-0856 AD - Division of Clinical Nutrition, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital and Chulalongkorn University, Bangkok, Thailand. Narisorn.L@chula.ac.th. FAU - Chanwigoon, Phatcharaporn AU - Chanwigoon P AD - Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital and Chulalongkorn University, Bangkok, Thailand. FAU - Hathayamat, Warasinee AU - Hathayamat W AD - Division of Clinical Nutrition, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital and Chulalongkorn University, Bangkok, Thailand. LA - eng PT - Journal Article DEP - 20251124 PL - England TA - Eur J Clin Nutr JT - European journal of clinical nutrition JID - 8804070 RN - J41CSQ7QDS (Zinc) SB - IM MH - Humans MH - Female MH - *Zinc/deficiency/blood MH - Male MH - *Liver Cirrhosis/complications/blood MH - Prospective Studies MH - Middle Aged MH - Risk Factors MH - Aged MH - *Mass Screening/methods MH - Nutritional Status MH - Adult MH - Prevalence MH - *Deficiency Diseases/diagnosis/epidemiology/blood MH - Ascites/etiology COIS- Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: Written informed consent was obtained from all participants prior to enrollment. EDAT- 2025/11/24 00:49 MHDA- 2026/01/09 00:26 CRDT- 2025/11/23 23:19 PHST- 2025/05/28 00:00 [received] PHST- 2025/11/12 00:00 [accepted] PHST- 2025/10/07 00:00 [revised] PHST- 2026/01/09 00:26 [medline] PHST- 2025/11/24 00:49 [pubmed] PHST- 2025/11/23 23:19 [entrez] AID - 10.1038/s41430-025-01684-0 [pii] AID - 10.1038/s41430-025-01684-0 [doi] PST - ppublish SO - Eur J Clin Nutr. 2026 Jan;80(1):113-120. doi: 10.1038/s41430-025-01684-0. Epub 2025 Nov 24. PMID- 41276452 OWN - NLM STAT- MEDLINE DCOM- 20260122 LR - 20260122 IS - 2095-4964 (Print) VI - 24 IP - 1 DP - 2026 Jan TI - Cutoff value for Pediatric Weakness Scale for diagnosis of pediatric weakness. PG - 105-114 LID - S2095-4964(25)00171-2 [pii] LID - 10.1016/j.joim.2025.11.002 [doi] AB - OBJECTIVE: In integrative traditional Korean medicine, children without abnormalities on medical examination but who frequently experience minor illnesses, fatigue and poor appetite are diagnosed as children with weakness. The Pediatric Weakness Scale (PWS) is a validated questionnaire for assessing pediatric weakness, but no standardized cutoff value exists. This study aimed to develop a validated cutoff value for PWS. METHODS: Parents of children aged 6-9 years were administered a survey to measure PWS, PedsQL Multidimensional Fatigue Scale (MFS), Korean Child Behavior Checklist (K-CBCL), Korean version of the Children's Eating Behavior Questionnaire (K-CEBQ), child growth indices, frequency of respiratory infections, and average duration of respiratory infections. The correlation between PWS and the results of each survey was analyzed using Pearson's or Spearman's correlation. The differences between the weak and normal groups were compared using independent sample t-tests or Mann-Whitney U tests. Receiver-operating characteristic (ROC) curves for the PWS subscale were generated based on five visceral theories (liver, heart, spleen, lung and kidney). The cutoff value was determined at the point that maximized Youden's index on the ROC curve. RESULTS: A total of 326 parents participated in the study. In PWS, the liver weakness index was significantly correlated with the MFS, heart weakness index with the K-CBCL, spleen weakness index with the K-CEBQ, lung weakness index with the frequency of respiratory infections, average duration of respiratory infections in the past year, and kidney weakness index with birth weight, height percentile, and weight percentile. Significant differences in each PWS subscale were observed between the weak and normal children. The cutoff values for diagnosing weakness in the liver, heart, spleen, lung and kidney were 4.50, 7.50, 4.50, 4.50 and 4.50, respectively, with sensitivity and specificity reaching up to 84.6% and 82.5%. CONCLUSION: The cutoff values for PWS derived from this survey will be a useful tool for diagnosing and assessing pediatric weakness. Please cite this article as: Kim TH, Chae H, Han JH, Bang MR, Chang GT, Lee JY, Lee SH. Cutoff value for Pediatric Weakness Scale for diagnosis of pediatric weakness. J Integr Med. 2026; 24(1):105-114. CI - Copyright (c) 2025 Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. Published by Elsevier B.V. All rights reserved. FAU - Kim, Tae Hwan AU - Kim TH AD - Department of Korean Pediatrics, College of Korean Medicine, Kyung Hee University Medical Center, Kyung Hee University, Seoul 02447, Republic of Korea. FAU - Chae, Han AU - Chae H AD - School of Korean Medicine, Pusan National University, Yangsan, Gyeongsangnam-do 50612, Republic of Korea. FAU - Han, Juhui AU - Han J AD - Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea. FAU - Bang, Miran AU - Bang M AD - Department of Korean Pediatrics, College of Korean Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul 05278, Republic of Korea. FAU - Chang, Gyu Tae AU - Chang GT AD - Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea; Department of Korean Pediatrics, College of Korean Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul 05278, Republic of Korea. FAU - Lee, Jin Yong AU - Lee JY AD - Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea. FAU - Lee, Sun Haeng AU - Lee SH AD - Department of Korean Pediatrics, College of Korean Medicine, Kyung Hee University Medical Center, Kyung Hee University, Seoul 02447, Republic of Korea; Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea. Electronic address: civil011@khu.ac.kr. LA - eng PT - Journal Article DEP - 20251105 PL - Netherlands TA - J Integr Med JT - Journal of integrative medicine JID - 101603118 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - Surveys and Questionnaires MH - *Fatigue/diagnosis MH - ROC Curve MH - *Muscle Weakness/diagnosis OTO - NOTNLM OT - Child OT - Deficiency OT - Diagnosis OT - Pediatric Weakness Scale OT - Questionnaire OT - ROC curve EDAT- 2025/11/24 00:49 MHDA- 2026/01/23 00:26 CRDT- 2025/11/23 21:52 PHST- 2024/06/11 00:00 [received] PHST- 2025/09/05 00:00 [accepted] PHST- 2026/01/23 00:26 [medline] PHST- 2025/11/24 00:49 [pubmed] PHST- 2025/11/23 21:52 [entrez] AID - S2095-4964(25)00171-2 [pii] AID - 10.1016/j.joim.2025.11.002 [doi] PST - ppublish SO - J Integr Med. 2026 Jan;24(1):105-114. doi: 10.1016/j.joim.2025.11.002. Epub 2025 Nov 5. PMID- 41272727 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260727 IS - 1479-5868 (Electronic) IS - 1479-5868 (Linking) VI - 22 IP - 1 DP - 2025 Nov 21 TI - Primary school-based food environment intervention increases diet diversity: Project Daire, a cluster randomized controlled trial. PG - 149 LID - 10.1186/s12966-025-01842-4 [doi] LID - 149 AB - BACKGROUND: This study explored the effects of Project Daire, a school-based food intervention, on secondary dietary outcomes Diet Diversity Score (DDS) and Diet Quality Score (DQS), among 6-7 and 10-11-year-old children. METHODS: A randomised-controlled, factorial design trial was conducted in 15 Northern Ireland primary schools across four intervention arms: Nourish, Engage, Nourish and Engage, and Control (Delayed). Nourish modified the school food environment and increased exposure to local foods, while Engage delivered educational activities on nutrition, food, and agriculture. Food consumption data were collected at baseline and at up to a 6-month follow-up. DDS and DQS (at home, at school and/or total) were determined based on the UK Eatwell Guide. RESULTS: A total of 445 children aged 6-7 and 458 aged 10-11 completed the trial. Among the 10-11-year-olds who received the Nourish intervention, significant increases were observed in the school DDS (adjusted mean difference = 2.79, 95% CI: 1.44-4.14; p < 0.001) and total DDS (adjusted mean difference = 1.55, 95% CI: 0.65-2.44; p = 0.001) compared to their counterparts who did not receive it. No such changes were observed in the DDS of 6-7-year-olds in the Nourish group, nor in either age group receiving the Engage intervention. The DQS of both age groups remained unchanged across all intervention groups. CONCLUSIONS: The Nourish intervention was associated with improved dietary diversity among older children through modifications to the whole-school environment. However, the absence of measurable effects on diet quality highlights the need for future iterations of Project Daire to incorporate additional strategies. These should include targeted approaches to improve diet quality, foster active parental engagement, utilize validated dietary assessment tools, and ensure sustained implementation. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04277312. FAU - Olgacher, Dilara AU - Olgacher D AD - Centre for Public Health, Queen's University Belfast, Belfast, UK. dolgacer01@qub.ac.uk. FAU - Wallace, Ciara AU - Wallace C AD - Centre for Public Health, Queen's University Belfast, Belfast, UK. FAU - Brennan, Sarah F AU - Brennan SF AD - Centre for Public Health, Queen's University Belfast, Belfast, UK. AD - Institute for Global Food Security, Queen's University Belfast, Belfast, UK. FAU - Lavelle, Fiona AU - Lavelle F AD - Department of Nutritional Sciences, School of Life Course and Population Sciences, King's College London, London, UK. FAU - Moore, Sarah E AU - Moore SE AD - Centre for Public Health, Queen's University Belfast, Belfast, UK. AD - Institute for Global Food Security, Queen's University Belfast, Belfast, UK. FAU - McKinley, Michelle C AU - McKinley MC AD - Centre for Public Health, Queen's University Belfast, Belfast, UK. AD - Institute for Global Food Security, Queen's University Belfast, Belfast, UK. FAU - McCole, Patrick AU - McCole P AD - School of Business, Maynooth University, Maynooth, County Kildare, Ireland. FAU - Hunter, Ruth F AU - Hunter RF AD - Centre for Public Health, Queen's University Belfast, Belfast, UK. FAU - Dunne, Laura AU - Dunne L AD - School of Social Sciences, Education and Social Work, Queen's University Belfast, Belfast, UK. FAU - Cardwell, Chris R AU - Cardwell CR AD - Centre for Public Health, Queen's University Belfast, Belfast, UK. FAU - McCarthy, Danielle AU - McCarthy D AD - Institute for Global Food Security, Queen's University Belfast, Belfast, UK. AD - Nutrition Talent Limited, Bangor, UK. FAU - Woodside, Jayne V AU - Woodside JV AD - Centre for Public Health, Queen's University Belfast, Belfast, UK. AD - Institute for Global Food Security, Queen's University Belfast, Belfast, UK. LA - eng SI - ClinicalTrials.gov/NCT04277312 PT - Journal Article PT - Randomized Controlled Trial DEP - 20251121 PL - England TA - Int J Behav Nutr Phys Act JT - The international journal of behavioral nutrition and physical activity JID - 101217089 SB - IM MH - Humans MH - Child MH - *Schools MH - Female MH - Northern Ireland MH - *Diet MH - Male MH - *Food Services MH - Feeding Behavior MH - *Health Promotion/methods MH - *Diet, Healthy PMC - PMC12639729 OTO - NOTNLM OT - Children OT - Diet diversity OT - Diet quality OT - Food education OT - Food environment OT - School-based intervention OT - Whole-school approach COIS- Declarations. Ethics approval and consent to participate: Ethical approval for Project Daire was obtained from The School of Social Sciences, Education and Social Work Ethics Committee, Queen's University Belfast (Reference number 038_1819). Parental informed consent was obtained for all children who participated in this trial. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/22 06:29 MHDA- 2026/06/27 06:44 PMCR- 2025/11/21 CRDT- 2025/11/22 00:15 PHST- 2025/04/16 00:00 [received] PHST- 2025/10/02 00:00 [accepted] PHST- 2026/06/27 06:44 [medline] PHST- 2025/11/22 06:29 [pubmed] PHST- 2025/11/22 00:15 [entrez] PHST- 2025/11/21 00:00 [pmc-release] AID - 10.1186/s12966-025-01842-4 [pii] AID - 1842 [pii] AID - 10.1186/s12966-025-01842-4 [doi] PST - epublish SO - Int J Behav Nutr Phys Act. 2025 Nov 21;22(1):149. doi: 10.1186/s12966-025-01842-4. PMID- 41269440 OWN - NLM STAT- MEDLINE DCOM- 20251121 LR - 20251124 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 30 IP - 1 DP - 2025 Nov 21 TI - Psychometric properties and factor structure of the Children's Eating Behavior Questionnaire in a Danish sample of children with overweight and obesity. PG - 89 LID - 10.1007/s40519-025-01798-1 [doi] LID - 89 AB - PURPOSE: The Children's Eating Behavior Questionnaire (CEBQ) is a reliable and widely used tool to assess eating behavior traits in children. However, currently no Danish version of the CEBQ exists. This study aimed to translate the CEBQ into Danish and investigate its psychometric properties and factor structure in children with overweight and obesity. Secondly, differences in eating behavior traits between children with overweight and obesity were explored. METHODS: Children (7-14 years) were recruited from a 10-week multicomponent lifestyle camp. Parents completed the CEBQ with their child before camp, and anthropometry was measured. CEBQ is scored from 1 to 5, with higher scores indicating a higher tendency toward a specific behavior. A confirmatory factor analysis (CFA) was performed to test the original eight-factor structure. Internal reliability was assessed using McDonald's Omega. RESULTS: In total, 190 children (12.3 +/- 1.36 years) participated. The CFA confirmed the eight-factor model, with all items loading significantly on their respective factors. Internal reliability was acceptable for the full CEBQ scale (omega = 0.85) and most subscales (omega >/= 0.70) but only moderate for Satiety Responsiveness (omega = 0.59) and Emotional Undereating (omega = 0.65). No statistically significant difference was found between children with overweight and obesity according to the Bonferroni-adjusted alpha. CONCLUSIONS: The Danish CEBQ is a valid tool to assess eating behavior traits in Danish children with overweight and obesity; although, generalizability may be limited due to a relatively small sample size. Future studies should further validate the Danish CEBQ by assessing test-retest reliability, construct validity, and factor structure in a generalizable sample across weight categories. LEVEL OF EVIDENCE: Level V, Cross-sectional, Psychometric study. CI - (c) 2025. The Author(s). FAU - Pauls, Dorthe Dalstrup AU - Pauls DD AUID- ORCID: 0000-0002-8579-3198 AD - Steno Diabetes Center Aarhus, Aarhus University Hospital, Palle Juul-Jensens Boulevard 11, Entrance A, 8200 Aarhus N, Denmark. dorthedalstrup@clin.au.dk. AD - Department of Clinical Medicine, Aarhus University, 8200 Aarhus N, Denmark. dorthedalstrup@clin.au.dk. AD - Danish National Center for Obesity, 8200 Aarhus N, Denmark. dorthedalstrup@clin.au.dk. FAU - Abild, Caroline Bruun AU - Abild CB AUID- ORCID: 0000-0003-4725-9880 AD - Steno Diabetes Center Aarhus, Aarhus University Hospital, Palle Juul-Jensens Boulevard 11, Entrance A, 8200 Aarhus N, Denmark. AD - Department of Clinical Medicine, Aarhus University, 8200 Aarhus N, Denmark. FAU - Clausen, Loa AU - Clausen L AUID- ORCID: 0000-0002-4559-8347 AD - Steno Diabetes Center Aarhus, Aarhus University Hospital, Palle Juul-Jensens Boulevard 11, Entrance A, 8200 Aarhus N, Denmark. AD - Department of Child and Adolescent Psychiatry, Aarhus University Hospital, 8200 Aarhus N, Denmark. FAU - Bruun, Jens Meldgaard AU - Bruun JM AUID- ORCID: 0000-0001-9937-5467 AD - Steno Diabetes Center Aarhus, Aarhus University Hospital, Palle Juul-Jensens Boulevard 11, Entrance A, 8200 Aarhus N, Denmark. AD - Department of Clinical Medicine, Aarhus University, 8200 Aarhus N, Denmark. AD - Danish National Center for Obesity, 8200 Aarhus N, Denmark. LA - eng PT - Journal Article DEP - 20251121 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - Child MH - Psychometrics MH - Female MH - Male MH - *Feeding Behavior/psychology MH - Adolescent MH - Denmark MH - Surveys and Questionnaires MH - Reproducibility of Results MH - *Overweight/psychology MH - Factor Analysis, Statistical MH - *Pediatric Obesity/psychology MH - *Child Behavior/psychology PMC - PMC12638412 OTO - NOTNLM OT - Adiposity OT - Children and Adolescents OT - Children's Eating Behavior Questionnaire OT - Eating Behavior Traits OT - Obesity OT - Validation COIS- Declarations. Ethics approval and consent to participate: This study protocol was approved by the local Committee of Ethics (Region Midtjylland no: 1-10-72-73-20). The present study conformed to the Declaration of Helsinki and was performed in accordance with good clinical practice. Written informed consent was obtained for participation in this study. Parents/guardians signed a written consent for their child to participate, and one parent/guardian signed a written consent for themselves to participate with their child. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/21 12:51 MHDA- 2025/11/21 18:25 PMCR- 2025/11/21 CRDT- 2025/11/21 11:19 PHST- 2025/02/13 00:00 [received] PHST- 2025/10/27 00:00 [accepted] PHST- 2025/11/21 18:25 [medline] PHST- 2025/11/21 12:51 [pubmed] PHST- 2025/11/21 11:19 [entrez] PHST- 2025/11/21 00:00 [pmc-release] AID - 10.1007/s40519-025-01798-1 [pii] AID - 1798 [pii] AID - 10.1007/s40519-025-01798-1 [doi] PST - epublish SO - Eat Weight Disord. 2025 Nov 21;30(1):89. doi: 10.1007/s40519-025-01798-1. PMID- 41267293 OWN - NLM STAT- MEDLINE DCOM- 20251121 LR - 20251121 IS - 1873-7145 (Electronic) IS - 0963-9969 (Linking) VI - 222 IP - Pt 1 DP - 2025 Dec TI - Intake of live microorganisms and microbial composition in the early stages of life. PG - 117717 LID - S0963-9969(25)02055-1 [pii] LID - 10.1016/j.foodres.2025.117717 [doi] AB - While diet is known to influence gut microbiota (GM), the role of live microorganisms (LMOs) has not been previously studied in early childhood. The objective of this study was to estimate the intake of LMOs during the first 48 months of life in a cohort of children and to study its potential impact on the GM. To this end, an LMO-content table was created, validated, and used to estimate LMO intake from dietary data obtained using a food frequency questionnaire (FFQ). The fecal microbiota was determined via 16S rRNA gene-based analyses, and SCFAs were quantified by gas chromatography. The intake of LMO increased with age from 6.69 log CFU/day at 0.5 and 3 months to 10.33 CFU/day at 48 months. Human milk was the main source of LMOs during the first 6 months of life, being milk and dairy products the main contributors later on. We observed significant associations between the fecal microbiota and metabolites and the intake of LMO at the different age periods analyzed. For instance, at 0.5 months of age, the intake of LMO was positively associated with the abundance of Bifidobacteriaceae and negatively with Enterococcaceae and propionic acid, at 3 months it was negatively associated with SCFAs and BCFAs, and at 6 months with butyric acid, whereas at 48 months the consumption of LMO was positively associated with Coriobacteriaceae. In conclusion, these findings suggest that LMO intake evolves with age and dietary sources, and is linked to specific changes in the GM in infants. CI - Copyright (c) 2025 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Perez, Eva Gomez AU - Perez EG AD - Department of Functional Biology, University of Oviedo, 33006 Oviedo, Asturias, Spain; Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lacteos de Asturias (IPLA-CSIC), 33011 Oviedo, Asturias, Spain; Institute of Health Research of the Principality of Asturias (ISPA), 33011 Oviedo, Asturias, Spain. FAU - Marino, Alejandra Rey AU - Marino AR AD - Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lacteos de Asturias (IPLA-CSIC), 33011 Oviedo, Asturias, Spain; Institute of Health Research of the Principality of Asturias (ISPA), 33011 Oviedo, Asturias, Spain. FAU - Arboleya, Silvia AU - Arboleya S AD - Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lacteos de Asturias (IPLA-CSIC), 33011 Oviedo, Asturias, Spain; Institute of Health Research of the Principality of Asturias (ISPA), 33011 Oviedo, Asturias, Spain. FAU - Gonzalez, Sonia AU - Gonzalez S AD - Department of Functional Biology, University of Oviedo, 33006 Oviedo, Asturias, Spain; Institute of Health Research of the Principality of Asturias (ISPA), 33011 Oviedo, Asturias, Spain. Electronic address: soniagsolares@uniovi.es. FAU - Gueimonde, Miguel AU - Gueimonde M AD - Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lacteos de Asturias (IPLA-CSIC), 33011 Oviedo, Asturias, Spain; Institute of Health Research of the Principality of Asturias (ISPA), 33011 Oviedo, Asturias, Spain. Electronic address: mgueimonde@ipla.csic.es. LA - eng PT - Journal Article DEP - 20251030 PL - Canada TA - Food Res Int JT - Food research international (Ottawa, Ont.) JID - 9210143 RN - 0 (RNA, Ribosomal, 16S) RN - 0 (Fatty Acids, Volatile) SB - IM MH - Humans MH - Infant MH - *Gastrointestinal Microbiome/physiology MH - Feces/microbiology MH - Female MH - Male MH - Child, Preschool MH - *Diet MH - Milk, Human/microbiology MH - RNA, Ribosomal, 16S/genetics MH - *Bacteria/classification/genetics MH - Fatty Acids, Volatile/analysis MH - Infant, Newborn MH - Dairy Products/microbiology OTO - NOTNLM OT - Children OT - Diet OT - Gut microbiota OT - Live microorganisms COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Miguel Gueimonde reports financial support was provided by Government of Principality of Asturias. Miguel Gueimonde reports financial support was provided by Government of Spain. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/11/21 06:27 MHDA- 2025/11/21 06:28 CRDT- 2025/11/21 01:00 PHST- 2025/05/28 00:00 [received] PHST- 2025/09/12 00:00 [revised] PHST- 2025/10/25 00:00 [accepted] PHST- 2025/11/21 06:28 [medline] PHST- 2025/11/21 06:27 [pubmed] PHST- 2025/11/21 01:00 [entrez] AID - S0963-9969(25)02055-1 [pii] AID - 10.1016/j.foodres.2025.117717 [doi] PST - ppublish SO - Food Res Int. 2025 Dec;222(Pt 1):117717. doi: 10.1016/j.foodres.2025.117717. Epub 2025 Oct 30. PMID- 41267149 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251121 LR - 20251124 IS - 2662-2211 (Electronic) IS - 2662-2211 (Linking) VI - 6 IP - 1 DP - 2025 Nov 20 TI - Community-engaged dissemination and implementation of an evidence-based health promotion intervention for Native American families: "Delivery of Turtle Island Tales to promote family wellness" protocol. PG - 126 LID - 10.1186/s43058-025-00803-z [doi] LID - 126 AB - BACKGROUND: Native American communities possess a wide range of assets that can contribute to reducing persistent inequities in food insecurity, obesity, cancer, chronic disease, and other related outcomes. Community engaged dissemination and implementation (CEDI) strategies that emphasize available, relevant, and generalizable evidence as well as community strengths and assets are well aligned to improve health outcomes with these communities. METHODS: "Delivery of Turtle Island Tales to Promote Family Wellness" applies a culturally grounded, evidence-based intervention for obesity prevention through partnership with local organizations (e.g., Cooperative Extension/Supplemental Nutrition Assistance Program Education [SNAP-Ed]) to understand and enhance community capacity for sustained health promotion. A descriptive case study design applies bundled CEDI strategies (e.g., participatory Project Steering Committee; site-specific Community Implementation Teams) guided by the Consolidated Framework for Implementation Research and the Reach, Effectiveness, Adoption, Implementation, and Maintenance Framework to examine implementation across multiple communities. CEDI strategies will be tracked longitudinally, by community, to document iterative identification of locally specific and project general CEDI strategies as they relate to program reach, adoption, adaptation, implementation, and maintenance using mixed methods approaches (e.g., validated surveys, focus groups, interviews). An economic assessment of Turtle Island Tales also will be conducted. DISCUSSION: This study applies innovative CEDI science to the equitable implementation of Turtle Island Tales, one of the only family-centered, home-based, evidence-based obesity prevention intervention developed for and with Native American communities. Key innovations include a mailed intervention model and culturally specific strategies that honor local community assets to support the program's relevance, scalability, and long-term sustainability. CI - (c) 2025. The Author(s). FAU - Tomayko, Emily J AU - Tomayko EJ AUID- ORCID: 0000-0002-9074-0875 AD - Center for American Indian and Rural Health Excellence, Montana State University, Bozeman, MT, 59718, US. emilytomayko@montana.edu. AD - Department of Food Systems, Nutrition and Kinesiology, Montana State University, Bozeman, MT, US. emilytomayko@montana.edu. FAU - Adams, Alexandra K AU - Adams AK AD - Center for American Indian and Rural Health Excellence, Montana State University, Bozeman, MT, 59718, US. FAU - Warne, Teresa AU - Warne T AD - Center for American Indian and Rural Health Excellence, Montana State University, Bozeman, MT, 59718, US. FAU - Merle, James L AU - Merle JL AD - Department of Population Health Sciences, University of Utah, Salt Lake City, UT, US. FAU - Estabrooks, Paul A AU - Estabrooks PA AD - Department of Health and Kinesiology, University of Utah, Salt Lake City, UT, US. LA - eng GR - U54 CA280812/CA/NCI NIH HHS/United States GR - 1U54CA280812/CA/NCI NIH HHS/United States GR - subproject 7190/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20251120 PL - England TA - Implement Sci Commun JT - Implementation science communications JID - 101764360 PMC - PMC12632114 OTO - NOTNLM OT - Childhood obesity prevention OT - Descriptive case study OT - Dissemination and implementation science OT - Evidenced-based interventions OT - Native American populations OT - Participatory action research OT - Poverty OT - Program sustainability OT - SNAP-Ed programming COIS- Declarations. Ethics approval and consent to participate: This study was approved as exempt by the institutional review boards (IRB) at Montana State University under IRB #2023-790-EXEMPT and by Blackfeet Nation IRB under IRB # E21-2. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/21 06:27 MHDA- 2025/11/21 06:28 PMCR- 2025/11/20 CRDT- 2025/11/21 00:09 PHST- 2025/08/18 00:00 [received] PHST- 2025/10/02 00:00 [accepted] PHST- 2025/11/21 06:28 [medline] PHST- 2025/11/21 06:27 [pubmed] PHST- 2025/11/21 00:09 [entrez] PHST- 2025/11/20 00:00 [pmc-release] AID - 10.1186/s43058-025-00803-z [pii] AID - 803 [pii] AID - 10.1186/s43058-025-00803-z [doi] PST - epublish SO - Implement Sci Commun. 2025 Nov 20;6(1):126. doi: 10.1186/s43058-025-00803-z. PMID- 41267046 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 25 IP - 1 DP - 2025 Nov 20 TI - Association of parental oral health literacy, early childhood oral health behaviors, and caries severity with oral health-related quality of life among preschool children. PG - 1808 LID - 10.1186/s12903-025-07159-9 [doi] LID - 1808 AB - OBJECTIVE: To investigate the relationship between parental oral health literacy (OHL), children's oral health behaviors and status, and oral health-related quality of life (OHRQoL) in preschool children, and to identify factors associated with OHRQoL. METHODS: A convenience sampling method was used to survey 221 pairs of preschool children and their parents who visited the pediatric dentistry department from September 2023 to May 2024. Data were collected through questionnaires, clinical examinations, and validated scales-including the Chinese version of the short-form Health Literacy Dental Scale (HeLD-14) for OHL and the Early Childhood Oral Health Impact Scale (ECOHIS) for OHRQoL-to analyze relationships between sociodemographic characteristics, parental OHL, children's oral health behaviors, oral health status, and dental caries severity with OHRQoL. Bivariate analysis, multiple stepwise linear regression, and hierarchical regression were performed to identify factors associated with preschool children's OHRQoL. RESULTS: Data from 206 children were analyzed. Parental OHL, children's oral health behaviors, and oral health status were all significantly associated with OHRQoL in preschool children. Multiple stepwise regression analysis identified several independent factors associated with OHRQoL (P < 0.05), including parental OHL (beta = -0.206, P = 0.001), age of starting toothbrushing (beta = 0.164, P = 0.008), frequency of sweet food intake (beta = 0.152, P = 0.013), caries severity (beta = 0.199, P = 0.002), and history of toothache (beta = 0.276, P < 0.001). Collectively, these factors accounted for 26.2% of the total variance in OHRQoL. CONCLUSIONS: OHRQoL in preschool children is associated with comprehensive factors, including family factors (parental OHL), oral health behaviors (age of starting toothbrushing, frequency of sweet food intake), and oral health status (caries severity, history of toothache). These findings suggest that strengthening parental OHL, implementing early oral hygiene interventions and limiting sugar consumption may be key strategies for improving OHRQoL among preschool children. FAU - Zhang, Bo AU - Zhang B AD - Department of Stomatology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Zhou, Fan AU - Zhou F AD - Department of Stomatology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Liu, Zihan AU - Liu Z AD - Department of Stomatology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Gong, Aixiu AU - Gong A AD - Department of Stomatology, Children's Hospital of Nanjing Medical University, Nanjing, China. gongax2013@163.com. FAU - Li, Mingrui AU - Li M AD - School of Nursing, Nanjing Medical University, Nanjing, China. limingrui@njmu.edu.cn. LA - eng GR - CGZH005/Pre-incubation Support Project for Sci-Tech Achievement Transformation of Children's Hospital of Nanjing Medical University/ GR - Jiangsu Education Departmentleft broken bracket2023right broken bracketNo.11/Project of "Nursing Science " Funded by the 4th Priority Discipline Development Program of Jiangsu Higher Education Institutions/ PT - Journal Article DEP - 20251120 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - *Quality of Life MH - Child, Preschool MH - *Oral Health MH - *Dental Caries MH - Female MH - *Parents/psychology MH - Male MH - *Health Literacy MH - *Health Behavior MH - Surveys and Questionnaires PMC - PMC12636172 OTO - NOTNLM OT - Dental caries OT - Oral health literacy OT - Oral health-related quality of life OT - Preschool children COIS- Declarations. Ethics approval and consent to participate: The study protocol was reviewed and approved by the Ethics Committee of Children's Hospital of Nanjing Medical University (Ethics No. 202309019-1). This study strictly adhered to the ethical standards for medical research involving human subjects, as set forth in the Declaration of Helsinki and its subsequent amendments. Participation in this study was completely voluntary. Written informed consent to participate was obtained from the parents or legal guardians of all participants under the age of 16 prior to their involvement in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/21 06:27 MHDA- 2026/06/27 00:59 PMCR- 2025/11/20 CRDT- 2025/11/21 00:06 PHST- 2025/07/10 00:00 [received] PHST- 2025/10/16 00:00 [accepted] PHST- 2026/06/27 00:59 [medline] PHST- 2025/11/21 06:27 [pubmed] PHST- 2025/11/21 00:06 [entrez] PHST- 2025/11/20 00:00 [pmc-release] AID - 10.1186/s12903-025-07159-9 [pii] AID - 7159 [pii] AID - 10.1186/s12903-025-07159-9 [doi] PST - epublish SO - BMC Oral Health. 2025 Nov 20;25(1):1808. doi: 10.1186/s12903-025-07159-9. PMID- 41265168 OWN - NLM STAT- MEDLINE DCOM- 20260114 LR - 20260919 IS - 1875-595X (Electronic) IS - 0020-6539 (Print) IS - 0020-6539 (Linking) VI - 76 IP - 1 DP - 2026 Feb TI - Biological Validation of the PSC-MCAT: Analyzing Dental Plaque Microbiota Across Caries Risk Levels in Preschoolers. PG - 104007 LID - S0020-6539(25)03290-3 [pii] LID - 10.1016/j.identj.2025.104007 [doi] LID - 104007 AB - OBJECTIVE: Although Caries Risk Assessment (CRA) tools are widely recognised in preventive dentistry for predicting dental caries risk in children, there is a notable lack of studies addressing CRA within the Chinese population. This study aimed to evaluate the biological validity of the modified caries-risk assessment tool for preschool children (PSC-MCAT) by analysing the oral microbiome of children stratified by caries risk. MATERIALS AND METHODS: A comprehensive analysis of the oral microbiome was conducted on 72 preschool children categorised into low- (L), moderate- (M), and high-risk (H) groups based on the PSC-MCAT criteria. Next-generation sequencing was employed to assess microbial diversity and structure. Statistical analyses were performed to identify significant differences among the risk groups. RESULTS: The analysis revealed statistically significant differences in microbial diversity and structure among the caries risk groups (P < .05). Specific caries risk biomarkers, including Scardovia, Prevotella, and Megasphaera, were significantly enriched in the H group (P < .05). Co-occurrence network analysis showed that the M group exhibited a more complex microbial network compared to the H group, while the L group displayed sparse ecological interactions. KEGG pathway analysis identified 8 differentially abundant metabolic pathways among the risk groups. Furthermore, certain biomarkers in the H group, such as Scardovia and Megasphaera, were associated with D-arginine and D-ornithine metabolic pathways (P < .05) and were closely linked to children's oral health behaviours, including sweet food intake frequency and regular fluoride application (P < .05). CONCLUSION: This study provides the first biological validation of the PSC-MCAT's risk stratification capacity, establishing a mechanistic link between clinical risk tiers and the dynamics of acidogenic pathobionts as well as host-microbe metabolic interactions. These findings offer valuable insights for prognostic predictions and targeted caries management strategies. CI - Copyright (c) 2025 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Jiang, Yiling AU - Jiang Y AD - College & Hospital of Stomatology, Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment, Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious Diseases, Key Laboratory of Research and Application of Stomatological Equipment, Education Department of Guangxi Zhuang Autonomous Region, Guangxi Medical University, Nanning, China; The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China. FAU - Xie, Yulu AU - Xie Y AD - College & Hospital of Stomatology, Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment, Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious Diseases, Key Laboratory of Research and Application of Stomatological Equipment, Education Department of Guangxi Zhuang Autonomous Region, Guangxi Medical University, Nanning, China. FAU - Liu, Fanghong AU - Liu F AD - College & Hospital of Stomatology, Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment, Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious Diseases, Key Laboratory of Research and Application of Stomatological Equipment, Education Department of Guangxi Zhuang Autonomous Region, Guangxi Medical University, Nanning, China. FAU - Qin, Yu AU - Qin Y AD - College & Hospital of Stomatology, Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment, Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious Diseases, Key Laboratory of Research and Application of Stomatological Equipment, Education Department of Guangxi Zhuang Autonomous Region, Guangxi Medical University, Nanning, China. FAU - Zhang, Yishan AU - Zhang Y AD - College & Hospital of Stomatology, Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment, Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious Diseases, Key Laboratory of Research and Application of Stomatological Equipment, Education Department of Guangxi Zhuang Autonomous Region, Guangxi Medical University, Nanning, China. FAU - Tang, Luoyan AU - Tang L AD - College & Hospital of Stomatology, Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment, Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious Diseases, Key Laboratory of Research and Application of Stomatological Equipment, Education Department of Guangxi Zhuang Autonomous Region, Guangxi Medical University, Nanning, China. FAU - Dong, Xiaohua AU - Dong X AD - College & Hospital of Stomatology, Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment, Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious Diseases, Key Laboratory of Research and Application of Stomatological Equipment, Education Department of Guangxi Zhuang Autonomous Region, Guangxi Medical University, Nanning, China. FAU - Li, Ling AU - Li L AD - College & Hospital of Stomatology, Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment, Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious Diseases, Key Laboratory of Research and Application of Stomatological Equipment, Education Department of Guangxi Zhuang Autonomous Region, Guangxi Medical University, Nanning, China. FAU - Chen, Shaoyong AU - Chen S AD - College & Hospital of Stomatology, Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment, Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious Diseases, Key Laboratory of Research and Application of Stomatological Equipment, Education Department of Guangxi Zhuang Autonomous Region, Guangxi Medical University, Nanning, China. FAU - Yuan, Bo AU - Yuan B AD - Department of Stomatology, Longhua People's Hospital, Longhua Hospital of Southern University of Science and Technology, Shenzhen, China; Longhua District Key Laboratory of Oral Microecology Medical Translation, Shenzhen, China; College of General Practice, Southern University of Science and Technology, Shenzhen, China; Stomatology School of Southern Medical University, Guangzhou, China. FAU - You, Yuehua AU - You Y AD - Department of Stomatology, Longhua People's Hospital, Longhua Hospital of Southern University of Science and Technology, Shenzhen, China; Longhua District Key Laboratory of Oral Microecology Medical Translation, Shenzhen, China; College of General Practice, Southern University of Science and Technology, Shenzhen, China; Stomatology School of Southern Medical University, Guangzhou, China. Electronic address: ally_you@foxmail.com. FAU - Qiu, Rongmin AU - Qiu R AD - College & Hospital of Stomatology, Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment, Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious Diseases, Key Laboratory of Research and Application of Stomatological Equipment, Education Department of Guangxi Zhuang Autonomous Region, Guangxi Medical University, Nanning, China. Electronic address: rongminqiu@hotmail.com. LA - eng PT - Journal Article PT - Validation Study DEP - 20251119 PL - England TA - Int Dent J JT - International dental journal JID - 0374714 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Child, Preschool MH - *Dental Caries/microbiology MH - *Microbiota MH - Risk Assessment/methods MH - Female MH - Male MH - *Dental Plaque/microbiology MH - Dental Caries Susceptibility MH - China MH - Biomarkers/analysis PMC - PMC12671355 OTO - NOTNLM OT - 16S rRNA OT - Biomarkers OT - Caries OT - Early childhood OT - Microbiota OT - Risk assessment COIS- Conflict of interest None disclosed. EDAT- 2025/11/21 00:27 MHDA- 2026/01/14 07:05 PMCR- 2025/11/19 CRDT- 2025/11/20 18:06 PHST- 2025/08/29 00:00 [received] PHST- 2025/10/07 00:00 [revised] PHST- 2025/10/10 00:00 [accepted] PHST- 2026/01/14 07:05 [medline] PHST- 2025/11/21 00:27 [pubmed] PHST- 2025/11/20 18:06 [entrez] PHST- 2025/11/19 00:00 [pmc-release] AID - S0020-6539(25)03290-3 [pii] AID - 104007 [pii] AID - 10.1016/j.identj.2025.104007 [doi] PST - ppublish SO - Int Dent J. 2026 Feb;76(1):104007. doi: 10.1016/j.identj.2025.104007. Epub 2025 Nov 19. PMID- 41263840 OWN - NLM STAT- MEDLINE DCOM- 20251120 LR - 20260225 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 11 DP - 2025 Nov 19 TI - Assessment of dietary practices and nutritional status of children aged 5 to 72 months: study protocol of a nationwide Polish cross-sectional study (PITNUTS 2024). PG - e100921 LID - 10.1136/bmjopen-2025-100921 [doi] LID - e100921 AB - INTRODUCTION: Optimal nutrition during early childhood is crucial for psychosomatic development and for preventing diet-related diseases. However, evidence from Poland highlights significant deviations from recommended dietary practices. The previous Polish Infants and Toddler Nutritional Study conducted in 2016 (PITNUTS 2016) revealed imbalances in nutrient intake among children aged 5-36 months. The aim of this study (PITNUTS 2024) is to assess the diet and nutritional status of infants and children aged 5-72 months, providing a broader understanding of eating behaviours across critical stages of growth and development and allowing evaluation of how dietary practices changed in recent years. METHODS AND ANALYSIS: This cross-sectional study will recruit a nationally representative sample of Polish infants and children aged 5 to 72 months using stratified random sampling. Survey interviews will be conducted with parents or legal guardians as proxy reporters for the children. Dietary practices will be evaluated through validated qualitative and quantitative dietary assessments, ensuring a comprehensive evaluation of food consumption and energy and nutrient intake. Dietary data will be collected using the 3 day food record and the survey questionnaire, including a food frequency questionnaire (FFQ). Daily energy and nutrient intake will be compared with national dietary standards and WHO guidelines. Dietary patterns will be derived based on the FFQ data. Nutritional status will be assessed based on measured anthropometric parameters. Energy, macro- and micronutrient intake as well as dietary patterns identified among children will be associated with nutritional status, including body mass index z-score and body weight status. ETHICS AND DISSEMINATION: The study has been approved by the ethics board of the Institute of Mother and Child. Written informed consent was obtained from all participants' parents or legal guardians before the interviews began. The results from this study will be presented at scientific conferences and published in peer-reviewed journals, contributing to nutrition policies in Poland and informing educational materials and dietary consultation services. TRIAL REGISTRATION NUMBER: NCT06417151, results. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Sawicki, Michal AU - Sawicki M AUID- ORCID: 0009-0004-4487-441X AD - Nutricia Foundation, Warsaw, Masovian Voivodeship, Poland michal.sawicki@yahoo.com. FAU - Kowalkowska, Joanna AU - Kowalkowska J AUID- ORCID: 0000-0003-1981-7320 AD - Department of Human Nutrition, University of Warmia and Mazury in Olsztyn, Olsztyn, Warmian-Masurian Voivodeship, Poland. FAU - Kulaga, Zbigniew AU - Kulaga Z AD - Department of Public Health, Children's Memorial Health Institute, Warsaw, Masovian Voivodeship, Poland. FAU - Socha, Piotr AU - Socha P AD - Department of Gastroenterology, Hepatology, Nutritional Disorders and Paediatrics, Children's Memorial Health Institute, Warszawa, Poland. FAU - Swiader-Lesniak, Anna AU - Swiader-Lesniak A AD - Department of Anthropology, Children's Memorial Health Institute, Warsaw, Masovian Voivodeship, Poland. FAU - Swiecicka-Ambroziak, Agnieszka AU - Swiecicka-Ambroziak A AD - Department of Medical Affairs and Market Access, Nutricia Poland Sp zoo, Warsaw, Masovian Voivodeship, Poland. FAU - Szajewska, Hanna AU - Szajewska H AD - Department of Paediatrics, Medical University of Warsaw, Warszawa, Poland. FAU - Wadolowska, Lidia AU - Wadolowska L AD - Department of Human Nutrition, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland. FAU - Weker, Halina AU - Weker H AD - Department of Nutrition, Institute of Mother and Child, Warsaw, Poland. LA - eng SI - ClinicalTrials.gov/NCT06417151 PT - Clinical Trial Protocol PT - Journal Article DEP - 20251119 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Cross-Sectional Studies MH - *Diet MH - Energy Intake MH - *Feeding Behavior MH - *Nutritional Status MH - Poland MH - Research Design MH - Observational Studies as Topic PMC - PMC12636990 OTO - NOTNLM OT - Body Mass Index OT - Child OT - NUTRITION & DIETETICS OT - Surveys and Questionnaires COIS- Competing interests: The authors have read the journal's policy on competing interests. The authors declare the following competing interests: MS is an employee of the Nutricia Foundation, which is the sponsor of this study. HS has participated in academic-related speaking engagements and/or received research funding from companies that manufacture infant formula. She also serves on the board of the Nutricia Foundation. The other authors have not reported any conflicts of interest. EDAT- 2025/11/20 13:39 MHDA- 2025/11/20 13:40 PMCR- 2025/11/19 CRDT- 2025/11/20 11:04 PHST- 2025/11/20 13:40 [medline] PHST- 2025/11/20 13:39 [pubmed] PHST- 2025/11/20 11:04 [entrez] PHST- 2025/11/19 00:00 [pmc-release] AID - bmjopen-2025-100921 [pii] AID - 10.1136/bmjopen-2025-100921 [doi] PST - epublish SO - BMJ Open. 2025 Nov 19;15(11):e100921. doi: 10.1136/bmjopen-2025-100921. PMID- 41261922 OWN - NLM STAT- MEDLINE DCOM- 20260305 LR - 20260813 IS - 1939-3806 (Electronic) IS - 1939-3792 (Print) IS - 1939-3806 (Linking) VI - 19 IP - 2 DP - 2026 Feb TI - Prevalence of OSA Risk and Bruxism in Children With Autism Spectrum Disorders. PG - e70149 LID - 10.1002/aur.70149 [doi] LID - e70149 AB - Children with autism spectrum disorder (ASD) often present with sleep disorders, including obstructive sleep apnea (OSA), a condition characterized by upper airway obstruction during sleep. Bruxism has been recently described as being associated with OSA. This study aimed to assess the prevalence of OSA risk and bruxism in pediatric ASD patients compared to age and sex-matched healthy controls using the validated screening tool Sleep-Related Breathing Disorder scale of the Pediatric Sleep Questionnaire (SRBD-PSQ). Fifty-eight consecutive pediatric ASD patients were screened for OSA and bruxism at the Dentistry Unit of A. Gemelli Policlinic and compared to 58 healthy patients using chi-square tests. Comparison between the two groups was repeated by controlling for body mass index (BMI) and behavioral symptoms with ANCOVA and logistic regression analyses. Of 58 ASD patients (10.3 +/- 3.3 y/o, 74.5% males), 60.3% presented with an increased OSA risk, compared to 13.8% in the controls (p < 0.001, OR = 3.682, 95% CI: 1.933, 7.012). After controlling for BMI (which was significantly higher among ASD patients), those with ASD had significantly higher odds of OSA risk compared to controls (OR = 9.6, 95% CI: 3.56, 26.21). After controlling for the SRBD-PSQ behavioral component, the association between ASD and OSA risk lost its significant difference (p < 0.862). No significant difference was found between ASD patients and controls in awake (3.6% vs. 6.9%, p = 0.680) and sleep (25.5% vs. 32.8%, p = 0.393) bruxism. Pediatric patients with ASD present at higher risk of OSA, most likely explained by the behavioral symptoms; self-reported bruxism did not significantly differ compared to healthy controls. CI - (c) 2025 The Author(s). Autism Research published by International Society for Autism Research and Wiley Periodicals LLC. FAU - Alessandri-Bonetti, Anna AU - Alessandri-Bonetti A AUID- ORCID: 0000-0003-2210-1403 AD - Institute of Dental Clinic, A. Gemelli University Policlinic IRCCS, Catholic University of Sacred Heart, Rome, Italy. AD - Postgraduate School of Orthodontics, Director: Prof. Massimo Cordaro, Catholic University of Sacred Heart, Rome, Italy. FAU - Guglielmi, Federica AU - Guglielmi F AUID- ORCID: 0000-0002-1812-0479 AD - Institute of Dental Clinic, A. Gemelli University Policlinic IRCCS, Catholic University of Sacred Heart, Rome, Italy. AD - Postgraduate School of Orthodontics, Director: Prof. Massimo Cordaro, Catholic University of Sacred Heart, Rome, Italy. FAU - Faustini, Andrea AU - Faustini A AD - Institute of Dental Clinic, A. Gemelli University Policlinic IRCCS, Catholic University of Sacred Heart, Rome, Italy. AD - Postgraduate School of Paediatric Dentistry, Director: Prof. Patrizia Gallenzi, Catholic University of Sacred Heart, Rome, Italy. FAU - Sangalli, Linda AU - Sangalli L AUID- ORCID: 0000-0002-1386-5594 AD - College of Dental Medicine - Illinois, Midwestern University, Downers Grove, Illinois, USA. FAU - Staderini, Edoardo AU - Staderini E AUID- ORCID: 0000-0003-1339-9172 AD - Institute of Dental Clinic, A. Gemelli University Policlinic IRCCS, Catholic University of Sacred Heart, Rome, Italy. AD - Postgraduate School of Orthodontics, Director: Prof. Massimo Cordaro, Catholic University of Sacred Heart, Rome, Italy. FAU - Gallenzi, Patrizia AU - Gallenzi P AD - Institute of Dental Clinic, A. Gemelli University Policlinic IRCCS, Catholic University of Sacred Heart, Rome, Italy. AD - Postgraduate School of Orthodontics, Director: Prof. Massimo Cordaro, Catholic University of Sacred Heart, Rome, Italy. AD - Postgraduate School of Paediatric Dentistry, Director: Prof. Patrizia Gallenzi, Catholic University of Sacred Heart, Rome, Italy. LA - eng PT - Journal Article DEP - 20251119 PL - United States TA - Autism Res JT - Autism research : official journal of the International Society for Autism Research JID - 101461858 SB - IM MH - Humans MH - Male MH - *Autism Spectrum Disorder/epidemiology/complications MH - Female MH - Child MH - Prevalence MH - *Sleep Apnea, Obstructive/epidemiology MH - *Bruxism/epidemiology MH - Risk Factors MH - Surveys and Questionnaires MH - Adolescent MH - Comorbidity MH - Body Mass Index PMC - PMC12948734 OAB - Children with autism spectrum disorder present a higher risk of suffering from obstructive sleep apnea according to the Sleep-Related Breathing Disorder scale of the Pediatric Sleep Questionnaire; however this result could be explained by the behavioral symptoms. Children with autism spectrum disorder do not report higher awake and/or sleep bruxism compared to peers without autism. OABL- eng OTO - NOTNLM OT - autism spectrum disorder OT - awake bruxism OT - obstructive sleep apnea OT - sleep bruxism OT - validated questionnaires COIS- The authors declare no conflicts of interest. EDAT- 2025/11/20 06:26 MHDA- 2026/03/06 09:08 PMCR- 2026/02/28 CRDT- 2025/11/20 03:04 PHST- 2025/10/09 00:00 [revised] PHST- 2025/06/18 00:00 [received] PHST- 2025/11/02 00:00 [accepted] PHST- 2026/03/06 09:08 [medline] PHST- 2025/11/20 06:26 [pubmed] PHST- 2025/11/20 03:04 [entrez] PHST- 2026/02/28 00:00 [pmc-release] AID - AUR70149 [pii] AID - 10.1002/aur.70149 [doi] PST - ppublish SO - Autism Res. 2026 Feb;19(2):e70149. doi: 10.1002/aur.70149. Epub 2025 Nov 19. PMID- 41261695 OWN - NLM STAT- MEDLINE DCOM- 20251120 LR - 20260205 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 104 IP - 44 DP - 2025 Oct 31 TI - Phenome-wide Mendelian randomization analysis reveals new risk factors for 4 inflammatory skin diseases. PG - e45569 LID - 10.1097/MD.0000000000045569 [doi] LID - e45569 AB - In dermatology, the understanding of the causal relationships between risk factors and inflammatory skin diseases has been an area of continuous research. Although many earlier studies have confirmed the causal relationships between some risk factors and 4 inflammatory skin diseases (acne vulgaris, atopic dermatitis [AD], psoriasis, and vitiligo). However, many new exposure factors still need to be discovered and confirmed by us which could significantly enhance our understanding of disease etiology and inform more effective prevention and treatment strategies. To bridge this knowledge gap, we conducted a phenome-wide Mendelian randomization analysis to explore the causal relationships between 3617 traits and 4 inflammatory skin diseases (acne vulgaris, AD, psoriasis, and vitiligo). These 3617 traits encompassed a broad spectrum, including: other diseases, dietary intake, anthropometric measures, immune and inflammatory factors, fatty acid and lipoprotein metabolism, lifestyle and behavior, metabolomics and proteomics. We employed Mendelian randomization analysis primarily based on 2 methods and conducted pleiotropy and heterogeneity checks to enhance the robustness of the results. Additionally, data from the FinnGen cohort was used for validation further improving the robustness of the results. The results of the Mendelian randomization analysis and subsequent verification indicate that 3 exposures are significantly associated with acne, including galanin and galanin message-associated peptide prepropeptide, among others. Furthermore, 18 exposures have been identified as suggestively associated, such as stearoylcarnitine and related compounds. In the context of AD, there are 8 significant exposures, including asthma, eosinophil cell count and so forth, and 59 suggestive exposures, such as sum eosinophil basophil counts, inflammatory bowel disease, et cetera. In the context of psoriasis, the analysis identified 16 significant exposures, including Trefoil factor 3, among others. Furthermore, 31 exposures were identified as suggestive, such as the sum of neutrophil and eosinophil counts, and interleukin 16. Finally, in the case of vitiligo, the analysis revealed 12 significant exposures, including childhood sunburn occasions, and 11 suggestive exposures, such as the percentage of eosinophils. This study provides new insights into exploring the causal relationship between new risk factors and 4 inflammatory skin diseases as well as the prevention and treatment of these 4 inflammatory skin diseases. CI - Copyright (c) 2025 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Zhang, Yibang AU - Zhang Y AD - School of Basic Medical Sciences, Dali University, Dali, Yunnan, China. FAU - Wang, Xiaoyan AU - Wang X AD - Department of Experimental Teaching Center, School of Intelligent Medicine and Biotechnology, Guilin Medical University, Guilin, Guangxi, China. AD - Key Laboratory of Biochemistry and Molecular Biology, Education Department of Guangxi Zhuang Autonomous Region, Guilin Medical University, Guilin, Guangxi, China. FAU - Yang, Jiankang AU - Yang J AUID- ORCID: 0000-0001-5224-7951 AD - School of Basic Medical Sciences, Dali University, Dali, Yunnan, China. LA - eng GR - 202401BA070001-066/Special Basic Cooperative Research Programs of Yunnan Provincial Undergraduate UniversitiesaeuroAssociation/ GR - 2025GXNSFHA069010/Guangxi Natural Science Foundation/ GR - YNWR-QNBJ-2020-239/Xingdian talent support plan/ PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - *Mendelian Randomization Analysis MH - Risk Factors MH - *Psoriasis/genetics/etiology/epidemiology MH - *Dermatitis, Atopic/genetics/etiology/epidemiology MH - *Vitiligo/genetics/etiology MH - *Acne Vulgaris/genetics/etiology/epidemiology MH - Phenomics MH - Genetic Predisposition to Disease MH - Phenotype PMC - PMC12582838 OTO - NOTNLM OT - Mendelian randomization OT - causal associations OT - inflammatory skin diseases OT - phenome-wide analysis OT - risk factors COIS- The authors have no conflicts of interest to disclose. EDAT- 2025/11/20 06:26 MHDA- 2025/11/20 06:27 PMCR- 2025/10/31 CRDT- 2025/11/20 01:01 PHST- 2025/05/23 00:00 [received] PHST- 2025/10/03 00:00 [accepted] PHST- 2025/11/20 06:27 [medline] PHST- 2025/11/20 06:26 [pubmed] PHST- 2025/11/20 01:01 [entrez] PHST- 2025/10/31 00:00 [pmc-release] AID - 00005792-202510310-00130 [pii] AID - MD-D-25-06242 [pii] AID - 10.1097/MD.0000000000045569 [doi] PST - ppublish SO - Medicine (Baltimore). 2025 Oct 31;104(44):e45569. doi: 10.1097/MD.0000000000045569. PMID- 41258368 OWN - NLM STAT- MEDLINE DCOM- 20251119 LR - 20251122 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Nov 19 TI - Motor engagement, physical activity intensity, and enjoyment in pre-school children during different game-based formats. PG - 40776 LID - 10.1038/s41598-025-24643-y [doi] LID - 40776 AB - This study aimed to compare two small and adjusted game formats (1v1 and 2v2) in basketball and soccer, focusing on preschool children's motor engagement, physical activity (PA) levels, and self-reported enjoyment across multiple sessions. A within-subjects repeated-measures design was used, involving 26 male preschool children (5.7 +/- 0.5 years old). In the basketball and soccer sessions, children played games targeting small goals (soccer) and lowered hoops represented by floor circles (basketball). During gameplay, participants wore accelerometers to measure physical activity levels, and trained observers recorded motor engagement using the Observational System for Recording Physical Activity in Children - Preschool Version (OSRAC-P). After each session, children rated their enjoyment using a validated preschool visual analog scale designed for real-time assessment of young children's enjoyment of physical activity. Results revealed significant effects of format on light (p = 0.012, d = 0.53) and vigorous PA (p < 0.001, d = 1.25), with 2v2 promoting more light PA and 1v1 provoking more vigorous PA. Sport type significantly influenced moderate PA (p = 0.007, d = 0.58), with soccer showing higher values than basketball. Motor engagement differed by condition; slow-easy movements were most frequent in 2v2 soccer (r = 0.56), while fast movements were highest in 1v1 formats (r >/= 0.52). Regarding enjoyment, 2v2 basketball consistently elicited greater scores across all dimensions-attraction (r = 0.59), preference (r = 0.63), environment (r = 0.69), and social engagement (r = 0.66)-compared to 1v1 soccer and basketball. In conclusion, the findings suggest that while more individual formats of play may support motor engagement and physical activity levels, games involving teammates and hand-based interaction may be more enjoyable for male preschoolers in short-term settings. Further studies are needed to determine whether these patterns extend to girls and to longer-term interventions. CI - (c) 2025. The Author(s). FAU - Guo, Xiaodan AU - Guo X AD - Gdansk University of Physical Education and Sport, Gdansk, 80-336, Poland. FAU - Zhao, Jun AU - Zhao J AD - Jinzhong University, Jinzhong, 030619, China. FAU - Trybulski, Robert AU - Trybulski R AD - Medical Department Wojciech Korfanty, Upper Silesian Academy in Katowice, Katowice, 40-659, Poland. AD - Provita Zory Medical Center, Zory, Poland. FAU - Jia, Xuguang AU - Jia X AD - The Third People's Hospital of Yibin, Yibin, 644000, Sichuan, China. FAU - Xu, Yifan AU - Xu Y AD - Gdansk University of Physical Education and Sport, Gdansk, 80-336, Poland. FAU - Li, Mingmao AU - Li M AD - Gdansk University of Physical Education and Sport, Gdansk, 80-336, Poland. FAU - Clemente, Filipe Manuel AU - Clemente FM AD - Gdansk University of Physical Education and Sport, Gdansk, 80-336, Poland. filipe.clemente5@gmail.com. LA - eng PT - Journal Article DEP - 20251119 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Male MH - Child, Preschool MH - *Exercise/psychology/physiology MH - *Basketball/psychology MH - *Soccer/psychology MH - *Pleasure MH - *Motor Activity/physiology MH - Female PMC - PMC12630930 OTO - NOTNLM OT - Ball games OT - Children OT - Enjoyment OT - Physical activity OT - Small-sided games COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics: Ethical code: the study was conducted under the approved protocol of Yibin Third People's Hospital (approval code YBSDSRMYY-2024-01, dated 16/01/2024). Informed consent: Prior to participation, the study design, risks, and benefits were explained to both participants and their legal guardians. Upon their consent, legal guardians signed a free informed consent form that explicitly detailed the option to withdraw from the study without penalty. EDAT- 2025/11/19 12:29 MHDA- 2025/11/19 12:30 PMCR- 2025/11/19 CRDT- 2025/11/19 09:30 PHST- 2025/09/01 00:00 [received] PHST- 2025/10/14 00:00 [accepted] PHST- 2025/11/19 12:30 [medline] PHST- 2025/11/19 12:29 [pubmed] PHST- 2025/11/19 09:30 [entrez] PHST- 2025/11/19 00:00 [pmc-release] AID - 10.1038/s41598-025-24643-y [pii] AID - 24643 [pii] AID - 10.1038/s41598-025-24643-y [doi] PST - epublish SO - Sci Rep. 2025 Nov 19;15(1):40776. doi: 10.1038/s41598-025-24643-y. PMID- 41258025 OWN - NLM STAT- MEDLINE DCOM- 20251119 LR - 20251215 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Nov 19 TI - Uncovering age-specific subtypes of pediatric obesity and metabolic syndrome using machine learning algorithms. PG - 40722 LID - 10.1038/s41598-025-24524-4 [doi] LID - 40722 AB - Identifying new subgroups among children and adolescents with obesity and metabolic syndrome requires advanced clustering techniques capable of analyzing complex multidimensional data. This study aimed to employ machine learning methods to enhance the classification of obesity and metabolic syndrome subgroups in youth, facilitating early detection and targeted intervention strategies. Data were derived from three nationwide, multicenter, school-based CASPIAN studies conducted in Iran during 2003-2004, 2009-2010, and 2015. After excluding metabolically healthy non-obese participants, the final sample included 382, 787, and 594 individuals aged 7-10, 11-14, and 15-18 years, respectively. Metabolic syndrome (MetS) status was defined according to Adult Treatment Panel III criteria. Unsupervised machine learning, specifically Gaussian Mixture Models (GMM), was applied to the top five principal components in each age group. The Davies-Bouldin index determined the optimal number of clusters. Clinical features associated with metabolism and obesity were analyzed within each cluster. In the 7-10 years group, six distinct clusters were identified based on key metabolic and anthropometric variables. The 11-14 years group yielded seven clusters, each with unique metabolic and anthropometric characteristics. For adolescents aged 15-18, six clusters reflected a more pronounced interaction between anthropometric measures and metabolic risk factors, consistent with physiological maturation. Stability tests showed mean clustering accuracies of 76.3%, 65.5%, and 52% for the three age groups, respectively. Predictability tests demonstrated an average accuracy exceeding 87% across all groups, indicating the robustness and reliability of the clustering approach. This study demonstrated that machine learning can uncover hidden metabolic and anthropometric heterogeneity in pediatric obesity, providing a methodological framework for identifying meaningful subgroups for targeted interventions. CI - (c) 2025. The Author(s). FAU - Mousavi, Elahe AU - Mousavi E AD - Department of Bioinformatics, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Mozafarian, Nafiseh AU - Mozafarian N AD - Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences Isfahan, Isfahan, Iran. FAU - Heidari-Beni, Motahar AU - Heidari-Beni M AD - Department of Nutrition, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran. heidari.motahar@gmail.com. FAU - Sehhati, Mohammadreza AU - Sehhati M AD - Department of Bioinformatics, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. mr.sehhati@gmail.com. FAU - Kelishadi, Roya AU - Kelishadi R AD - Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences Isfahan, Isfahan, Iran. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20251119 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Adolescent MH - *Metabolic Syndrome/classification/epidemiology/diagnosis MH - Child MH - Male MH - Female MH - *Pediatric Obesity/classification/epidemiology/diagnosis MH - *Machine Learning MH - Age Factors MH - Cluster Analysis MH - Algorithms MH - Iran/epidemiology MH - Risk Factors PMC - PMC12630947 OTO - NOTNLM OT - Clustering OT - Machine learning OT - Metabolic syndrome OT - Obesity COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval and consent to participate: This study was approved by the Ethics Committee of Isfahan University of Medical Sciences (Research ethics code: IR.ARI.MUI.REC.1402.286). Informed oral assent and written consent forms were collected from participants and parents respectively after a description of the aims and protocol of the study. EDAT- 2025/11/19 12:28 MHDA- 2025/11/19 12:29 PMCR- 2025/11/19 CRDT- 2025/11/19 09:08 PHST- 2025/07/19 00:00 [received] PHST- 2025/10/14 00:00 [accepted] PHST- 2025/11/19 12:29 [medline] PHST- 2025/11/19 12:28 [pubmed] PHST- 2025/11/19 09:08 [entrez] PHST- 2025/11/19 00:00 [pmc-release] AID - 10.1038/s41598-025-24524-4 [pii] AID - 24524 [pii] AID - 10.1038/s41598-025-24524-4 [doi] PST - epublish SO - Sci Rep. 2025 Nov 19;15(1):40722. doi: 10.1038/s41598-025-24524-4. PMID- 41257958 OWN - NLM STAT- MEDLINE DCOM- 20251119 LR - 20251122 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Nov 19 TI - Gender differences in diet and health promoting nutrition among university students. PG - 40778 LID - 10.1038/s41598-025-24604-5 [doi] LID - 40778 AB - Improper dietary habits among students are a growing public health concern, as they contrib-ute to diet-related diseases. This study aimed to assess the frequency of food consumption among students, with analysis of factors influencing their choices and potential health conse-quences, particularly regarding health-promoting properties of the diet. A total of 1269 students (436 women and 833 men) from the Jozef Pilsudski University of Physical Education in Warsaw participated in the study. The average age was about 20 years, mean body weight 72 kg, and mean height 177 cm. Eating habits were evaluated using the validated Food Frequency Questionnaire (FFQ-6), and diet quality was assessed with the Pro-Health Diet Index (pHDI-10). Significant gender differences were found in the consumption of refined bread, butter, fruits, vegetables, red meat, and poultry. Men also consumed fruit juices, sweetened beverages, beer, wine, and vodka more frequently than women. Overall, the majority of participants' diets had a low probability of health-promoting properties. In conclusion, student diets show limited health-promoting potential and indicate a high pre-disposition to diet-related diseases. These results highlight the importance of implementing educational programs promoting rational nutrition and healthy lifestyle choices in the student population. CI - (c) 2025. The Author(s). FAU - Malara, Marzena AU - Malara M AD - Department of Human Biology, Faculty of Physical Education, Jozef Pilsudski University of Physical Education, 34 Marymoncka St., 00-968, Warsaw, Poland. marzena.malara@awf.edu.pl. FAU - Widlak, Patrycja AU - Widlak P AD - Department of Human Biology, Faculty of Physical Education, Jozef Pilsudski University of Physical Education, 34 Marymoncka St., 00-968, Warsaw, Poland. FAU - Tomczyk, Lukasz AU - Tomczyk L AD - Department of Food Quality and Safety Management, Faculty of Food Science and Nutrition, University of Life Sciences, 28 Wojska Polskiego St., 60-637, Poznan, Poland. LA - eng PT - Journal Article DEP - 20251119 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Male MH - *Students MH - Universities MH - Young Adult MH - *Feeding Behavior MH - *Diet MH - Adult MH - *Health Promotion MH - Sex Factors MH - Surveys and Questionnaires MH - Poland MH - Adolescent PMC - PMC12630838 OTO - NOTNLM OT - College students OT - Educational programs OT - Food Frequency Questionnaire FFQ-6 OT - Health-Promoting Diet Index OT - National dietary habits OT - Poland COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: All participants provided written consent to participate in the study and the study protocol was approved by the Ethics Committee of the Jozef Pilsudski University of Physical Education, Warsaw, Poland (SKE 01-40/2022). EDAT- 2025/11/19 12:28 MHDA- 2025/11/19 12:29 PMCR- 2025/11/19 CRDT- 2025/11/19 09:02 PHST- 2025/04/02 00:00 [received] PHST- 2025/10/14 00:00 [accepted] PHST- 2025/11/19 12:29 [medline] PHST- 2025/11/19 12:28 [pubmed] PHST- 2025/11/19 09:02 [entrez] PHST- 2025/11/19 00:00 [pmc-release] AID - 10.1038/s41598-025-24604-5 [pii] AID - 24604 [pii] AID - 10.1038/s41598-025-24604-5 [doi] PST - epublish SO - Sci Rep. 2025 Nov 19;15(1):40778. doi: 10.1038/s41598-025-24604-5. PMID- 41257929 OWN - NLM STAT- MEDLINE DCOM- 20251119 LR - 20251215 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 13 IP - 1 DP - 2025 Nov 19 TI - The influence of public welfare sports on college students' sports interest and sports behavior: a longitudinal study. PG - 1282 LID - 10.1186/s40359-025-03606-y [doi] LID - 1282 AB - BACKGROUND: The decreasing interest and participation in sports among university students has become a growing concern, negatively impacting their physical and mental health. Modern university students engage less in regular physical exercise despite having more leisure time. This study explores whether integrating public welfare activities into sports can enhance students' interest and participation in physical activities. METHODS: A longitudinal intervention experiment was conducted with 360 university students from Zhejiang Province, randomly assigned to an experimental group (248 students) and a control group (112 students). The experimental group participated in sports activities integrated with public welfare initiatives, while the control group engaged in a general sports project without philanthropic elements. Changes in sports behavior were assessed using a stage classification model of exercise participation, and sports interest was measured through validated questionnaires. RESULTS: The research results figure out that the Public Welfare Sports can distinctly promote periodic change of the Students' Exercises Interests and Behavior. When controlled the Low-initial exercises interests, the exercises interests contribute to the significant of positive effect on the interests in public welfare sports. The influence of public welfare sports on the Students' Exercises Interests & Behavior is distinct. This study enriches the relevant theories of public welfare sport area and as a reference for theoretical support for how to better plan public welfare sports programs, in this way the public welfare and the sports can be combined effectively as well as promoting the students' interest in sports. CONCLUSION: The study suggests that public welfare engagement can drive behavioral change, offering valuable insights for designing sports programs that effectively encourage sustained participation. CI - (c) 2025. The Author(s). FAU - Dong, Yu AU - Dong Y AD - Department of Basic Education, Wuhan Donghu College, Wuhan, 430212, China. FAU - Weng, Shiyang AU - Weng S AD - Department of Basic Education, Wuhan Donghu College, Wuhan, 430212, China. 20195107@wzu.edu.cn. FAU - Wang, Yuxi AU - Wang Y AD - Physical Education and Research, Wuhan Donghu College, Wuhan, 430212, China. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20251119 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Longitudinal Studies MH - Male MH - Female MH - *Students/psychology MH - *Sports/psychology MH - Universities MH - Young Adult MH - *Social Welfare/psychology MH - Surveys and Questionnaires MH - Exercise/psychology MH - China MH - Adult MH - Adolescent PMC - PMC12628884 OTO - NOTNLM OT - Exercises behavior OT - Exercises interests OT - Periodic change of the students OT - Public welfare sports COIS- Declarations. Ethics approval and consent to participate: All procedures involving human participants in this study were conducted in accordance with the Declaration of Helsinki (as revised in 2013). The study received approval from the Ethics Committee of Wuhan Donghu University, Wuhan, China. All participants provided written informed consent. All procedures were conducted in accordance with the relevant guidelines and regulations outlined in the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/19 12:28 MHDA- 2025/11/19 12:29 PMCR- 2025/11/19 CRDT- 2025/11/19 08:59 PHST- 2025/03/06 00:00 [received] PHST- 2025/10/23 00:00 [accepted] PHST- 2025/11/19 12:29 [medline] PHST- 2025/11/19 12:28 [pubmed] PHST- 2025/11/19 08:59 [entrez] PHST- 2025/11/19 00:00 [pmc-release] AID - 10.1186/s40359-025-03606-y [pii] AID - 3606 [pii] AID - 10.1186/s40359-025-03606-y [doi] PST - epublish SO - BMC Psychol. 2025 Nov 19;13(1):1282. doi: 10.1186/s40359-025-03606-y. PMID- 41257712 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 25 IP - 1 DP - 2025 Nov 19 TI - Unveiling the risks and outcomes of preeclampsia: a case-control study in the UAE. PG - 1247 LID - 10.1186/s12884-025-08448-5 [doi] LID - 1247 AB - BACKGROUND: Preeclampsia is a pregnancy-related disorder characterized by high blood pressure and often proteinuria, affecting 2-8% of pregnancies worldwide. Preeclampsia is linked to various factors, including diabetes, obesity, multiple pregnancies, primiparity, age over 30, family history, lifestyle habits, and chronic hypertension. This study aimed to identify the determinants of preeclampsia as well as the maternal-fetal outcomes associated with it. METHODS: An unmatched case-control study included adults over 18 years old in the United Arab Emirates diagnosed with preeclampsia, who provided consent. Controls included those without preeclampsia. A total of 545 participants were included, with a 1:3 case-to-control ratio, recruited via convenience sampling from Thumbay University Hospital, Ajman. A content-validated questionnaire gathered data on socio-demographics, medical history, reproductive/obstetric history, surgical history, family history, and lifestyle factors from medical records and through Google Forms from the participants. Chi-square and logistic regression analyses were performed on Statistical Package for Social Sciences (SPSS) version 29. A p-value < 0.05 was considered statistically significant. RESULTS: Age at first pregnancy at 17-20 (aOR = 4.909) and 21-29 years old (aOR = 3.209), thyroid disorders (aOR = 4.346), allergy (aOR = 6.899), and family history of hypertension (aOR = 3.323) were independent predictors of preeclampsia. Maternal and neonatal outcomes, including persistent hypertension, postpartum depression, preterm birth, placental abruption, and neonatal respiratory distress, were also assessed. CONCLUSION: The results of this study highlight the importance of early detection of preeclampsia in at-risk individuals and addressing modifiable risk factors like stress and nutrition to reduce unfavourable pregnancy outcomes and to mitigate risk. Targeted interventions, such as raising pregnant women's awareness, can help reduce the adverse outcomes. These findings also highlight the necessity for improving the overall maternal and fetal health and minimizing the complications that are associated with preeclampsia. FAU - Nandagopal, Preethi AU - Nandagopal P AD - College of Medicine, Gulf Medical University, Ajman, United Arab Emirates. FAU - Sanaullah, Afreen Abdul Rahim AU - Sanaullah AAR AD - College of Medicine, Gulf Medical University, Ajman, United Arab Emirates. FAU - Nandagopal, Sathyapriya AU - Nandagopal S AD - College of Medicine, Gulf Medical University, Ajman, United Arab Emirates. FAU - Wazil, Shahnaz Mohamed AU - Wazil SM AD - College of Medicine, Gulf Medical University, Ajman, United Arab Emirates. FAU - Muhammed, Shameema Asif AU - Muhammed SA AD - Department of Obstetrics and Gynaecology, Thumbay University Hospital, Ajman, United Arab Emirates. FAU - Sreejith, Anusha AU - Sreejith A AD - Department of Community Medicine, College of Medicine, Gulf Medical University, Ajman, United Arab Emirates. anusha@gmu.ac.ae. LA - eng PT - Journal Article DEP - 20251119 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Pre-Eclampsia/epidemiology/etiology MH - Case-Control Studies MH - Adult MH - United Arab Emirates/epidemiology MH - Risk Factors MH - Young Adult MH - *Pregnancy Outcome/epidemiology MH - Adolescent PMC - PMC12628982 OTO - NOTNLM OT - High blood pressure OT - Maternal health OT - Maternal-fetal outcomes OT - Multigravidity OT - Preeclampsia OT - Pregnant women COIS- Declarations. Ethics approval and consent to participate: The Institutional Review Board of Gulf Medical University in Ajman, United Arab Emirates, granted ethical approval (Ref. no. IRB-COM-STD-79-Oct-2024). Before taking part in the study, participants gave their agreement, and the questionnaire was finalized after being validated by three obstetrics and gynecology specialists at the Thumbay University Hospital, Ajman. Participants' privacy, anonymity, and confidentiality were maintained. The research was conducted in accordance with the Helsinki Declaration. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/19 12:28 MHDA- 2026/06/27 00:55 PMCR- 2025/11/19 CRDT- 2025/11/19 08:18 PHST- 2025/07/12 00:00 [received] PHST- 2025/10/29 00:00 [accepted] PHST- 2026/06/27 00:55 [medline] PHST- 2025/11/19 12:28 [pubmed] PHST- 2025/11/19 08:18 [entrez] PHST- 2025/11/19 00:00 [pmc-release] AID - 10.1186/s12884-025-08448-5 [pii] AID - 8448 [pii] AID - 10.1186/s12884-025-08448-5 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2025 Nov 19;25(1):1247. doi: 10.1186/s12884-025-08448-5. PMID- 41255304 OWN - NLM STAT- MEDLINE DCOM- 20260129 LR - 20260129 IS - 1365-3016 (Electronic) IS - 0269-5022 (Linking) VI - 40 IP - 1 DP - 2026 Jan TI - Predicting the Risk of Stillbirth for Small Infants Using Maternal and Pregnancy Characteristics. PG - 4-16 LID - 10.1111/ppe.70097 [doi] AB - BACKGROUND: The risk of stillbirth increases as birthweight falls below the 25th centile. To mitigate this risk, many infants are delivered at late preterm or early term gestations, which increases the risk of neonatal and longer-term complications. OBJECTIVE: To develop a model to predict the risk of stillbirth for small infants after 34(+0) weeks using information available antenatally. METHODS: This was a retrospective cohort study of non-anomalous singleton infants >/= 34(+0) weeks of gestation with birthweight (BW) < 25th centile, born between 2000 and 2021 in Queensland, Australia. The study outcome was antepartum stillbirth. We used survival analysis to model the number of gestational weeks each pregnancy is at risk of antepartum stillbirth. Competing risks regression models were then built to account for informative censoring due to planned birth. For ease of clinical translatability, we developed a clinical scoring rule to present the probabilities of stillbirth at each gestational week. The dataset was split into testing and discovery cohorts for assessment of internal validation, model discrimination, and concordance. RESULTS: There were 259,378 infants with BW < 25th centile, including 646 stillbirths (0.25%). The strongest predictors were BW centile < 1 (sub-hazard ratio [SHR] 5.84, 95% confidence interval [CI] 4.60, 7.42), BW centiles 1-2 (SHR 3.10, 95% CI 2.46, 3.91), < 5 antenatal visits (SHR 2.91, 95% CI 2.39, 3.55), BW centiles 3-4 (SHR 2.23, 95% CI 1.72, 2.89) and BMI >/= 35 kg/m(2) (SHR 2.24, 95% CI 1.52, 3.29). Other predictors in the model were hypertension, anaemia, and asthma. Across all point scores, the cumulative incidence of stillbirth increased with gestation. Harrell's C-statistics were consistent across the discovery (0.71) and testing cohorts (0.73). CONCLUSIONS: Our prediction model for small infants may be useful to risk-stratify women according to their stillbirth risk and support decisions around the timing of birth. CI - (c) 2025 John Wiley & Sons Ltd. FAU - Triggs, Tegan AU - Triggs T AD - Mater Research Institute, University of Queensland, Brisbane, Queensland, Australia. AD - School of Medicine, The University of Queensland, Herston, Queensland, Australia. AD - Royal Brisbane and Women's Hospital, Herston, Queensland, Australia. FAU - Crawford, Kylie AU - Crawford K AD - Mater Research Institute, University of Queensland, Brisbane, Queensland, Australia. AD - School of Medicine, The University of Queensland, Herston, Queensland, Australia. FAU - Flenady, Vicki AU - Flenady V AD - NHMRC Centre for Research Excellence in Stillbirth, Mater Research Institute, University of Queensland, Brisbane, Queensland, Australia. FAU - Kumar, Sailesh AU - Kumar S AD - Mater Research Institute, University of Queensland, Brisbane, Queensland, Australia. AD - School of Medicine, The University of Queensland, Herston, Queensland, Australia. AD - Royal Brisbane and Women's Hospital, Herston, Queensland, Australia. AD - NHMRC Centre for Research Excellence in Stillbirth, Mater Research Institute, University of Queensland, Brisbane, Queensland, Australia. LA - eng GR - 2021/GNT2009216/National Health and Medical Research Council/ GR - Royal Australian College of Obstetricians and Gynaecologists Women's Health Foundation/ GR - PHD00120/Cerebral Palsy Alliance/ GR - Mater Foundation/ GR - University of Queensland Research Scholarship/ PT - Journal Article DEP - 20251119 PL - England TA - Paediatr Perinat Epidemiol JT - Paediatric and perinatal epidemiology JID - 8709766 SB - IM MH - Humans MH - Female MH - *Stillbirth/epidemiology MH - Pregnancy MH - Retrospective Studies MH - Infant, Newborn MH - Adult MH - Gestational Age MH - Risk Assessment/methods MH - Queensland/epidemiology MH - *Infant, Small for Gestational Age MH - Risk Factors MH - *Birth Weight MH - Male OTO - NOTNLM OT - clinical decision rules OT - fetal growth restriction OT - planned birth OT - risk assessment OT - small for gestational age OT - stillbirth OT - third trimester ultrasound EDAT- 2025/11/19 06:32 MHDA- 2026/01/29 07:35 CRDT- 2025/11/19 04:53 PHST- 2025/10/28 00:00 [revised] PHST- 2025/04/16 00:00 [received] PHST- 2025/11/03 00:00 [accepted] PHST- 2026/01/29 07:35 [medline] PHST- 2025/11/19 06:32 [pubmed] PHST- 2025/11/19 04:53 [entrez] AID - 10.1111/ppe.70097 [doi] PST - ppublish SO - Paediatr Perinat Epidemiol. 2026 Jan;40(1):4-16. doi: 10.1111/ppe.70097. Epub 2025 Nov 19. PMID- 41254858 OWN - NLM STAT- MEDLINE DCOM- 20251119 LR - 20260918 IS - 1365-277X (Electronic) IS - 0952-3871 (Linking) VI - 38 IP - 6 DP - 2025 Dec TI - Turkish Psychometric Properties of the Gluten-Free Diet Adherence Survey for Children With Coeliac Disease. PG - e70167 LID - 10.1111/jhn.70167 [doi] AB - PURPOSE: Coeliac disease is a chronic autoimmune condition that significantly impairs health and quality of life if not managed through strict dietary adherence. Given that existing adherence assessment tools are primarily designed for adults, a child-focused, noninvasive scale is needed to accurately evaluate gluten-free diet compliance in the paediatric population. This study aimed to evaluate the Turkish psychometric properties of an adapted Gluten-Free Diet Adherence Survey originally designed for adults but modified for children aged 9-18 years with coeliac disease. METHODS: A cross-sectional, methodological study was conducted with 211 children aged 9-18 years recruited from coeliac associations in Izmir and Istanbul. An expert panel simplified the language of the original adult survey, and a pilot study confirmed its readability and comprehension among children. The validation process employed exploratory and confirmatory factor analyses, internal consistency reliability assessments (Cronbach's alpha) and response bias evaluations. RESULTS: Children (mean age 11.95 +/- 2.87) achieved an average adherence score of 20 (range: 7-35), indicating moderate compliance with notable barriers to complete adherence. Furthermore, 45% of the participants maintained a gluten-free diet for 5-10 years, highlighting long-term sustainability. Factor loadings ranged from 0.40 to 0.75, and the scale demonstrated excellent model-data fit indices along with acceptable internal consistency (Cronbach's alpha = 0.797). CONCLUSION: The adapted Gluten-Free Diet Adherence Survey is a valid and reliable instrument for assessing dietary compliance in Turkish children with coeliac disease, underscoring the need for targeted interventions to enhance adherence and improve clinical outcomes. CI - (c) 2025 British Dietetic Association. FAU - Ozdemir, Emine Zahide AU - Ozdemir EZ AUID- ORCID: 0000-0002-4292-8849 AD - Department of Pediatric Nursing, Dokuz Eylul University Faculty of Nursing, Izmir, Turkey. FAU - Bektas, Murat AU - Bektas M AUID- ORCID: 0000-0003-3327-8204 AD - Department of Pediatric Nursing, Dokuz Eylul University Faculty of Nursing, Izmir, Turkey. FAU - Ergun, Pelin AU - Ergun P AUID- ORCID: 0000-0002-3155-0633 AD - Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. LA - eng GR - The authors received no specific funding for this work./ PT - Journal Article PT - Validation Study PL - England TA - J Hum Nutr Diet JT - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JID - 8904840 SB - IM MH - Humans MH - *Celiac Disease/diet therapy/psychology MH - Child MH - *Diet, Gluten-Free/psychology MH - Turkey MH - Adolescent MH - Male MH - Cross-Sectional Studies MH - Female MH - *Psychometrics MH - *Patient Compliance/psychology/statistics & numerical data MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - Pilot Projects MH - Factor Analysis, Statistical MH - Quality of Life MH - *Diet Surveys OTO - NOTNLM OT - coeliac disease OT - dietary adherence OT - gluten-free diet OT - paediatric OT - psychometric validation EDAT- 2025/11/19 06:32 MHDA- 2025/11/19 06:33 CRDT- 2025/11/19 00:15 PHST- 2025/10/23 00:00 [revised] PHST- 2025/08/01 00:00 [received] PHST- 2025/11/05 00:00 [accepted] PHST- 2025/11/19 06:33 [medline] PHST- 2025/11/19 06:32 [pubmed] PHST- 2025/11/19 00:15 [entrez] AID - 10.1111/jhn.70167 [doi] PST - ppublish SO - J Hum Nutr Diet. 2025 Dec;38(6):e70167. doi: 10.1111/jhn.70167. PMID- 41252347 OWN - NLM STAT- MEDLINE DCOM- 20251118 LR - 20260925 IS - 1549-1676 (Electronic) IS - 1549-1277 (Print) IS - 1549-1277 (Linking) VI - 22 IP - 11 DP - 2025 Nov TI - Diagnostic accuracy of the WHO tuberculosis treatment decision algorithms for children with presumptive tuberculosis: An individual participant data meta-analysis. PG - e1004610 LID - 10.1371/journal.pmed.1004610 [doi] LID - e1004610 AB - INTRODUCTION: In 2023, almost 200,000 children under 15 years died from tuberculosis, most without appropriate treatment. Treatment decision algorithms (TDAs), developed to facilitate rapid anti-tuberculosis treatment initiation in children, were recommended by the World Health Organization (WHO) in 2022, conditional on validation in different cohorts and settings. We performed a retrospective external evaluation of WHO TDAs using an individual participant dataset (IPD). METHODS AND FINDINGS: The IPD comprised four paediatric cohorts, restricted to children with presumptive pulmonary TB < 10 years, and including children in high-risk groups (children living with HIV "CLHIV", children with severe acute malnutrition "SAM", and children <2 years). All children in the IPD were retrospectively evaluated using both TDA A (an algorithm including chest X-ray) and TDA B (without chest X-ray), excluding the triage step. The diagnostic accuracy against a composite reference standard (confirmed and unconfirmed tuberculosis versus unlikely tuberculosis) was determined and reported as sensitivities and specificities. Of 1,886 children included (RaPaed-TB: n = 740, Umoya: n = 474, TB-Speed HIV: n = 204, TB-Speed Decentralisation: n = 468), the median age was 2.9 years (interquartile range [IQR]:1.3,5.5), 741 (39.3%) were <2 years, 382 (20.3%) were CLHIV, and 284 (15.1%) had SAM. 281 (14.9%) had confirmed tuberculosis, 672 (35.6%) were classified as unconfirmed tuberculosis (clinically diagnosed, microbiological investigations negative), and 933 (49.5%) as unlikely tuberculosis. For TDAs A and B, algorithm sensitivity was 84.3% (95% CI: 74.8, 90.6) and 90.6% (95% CI: 83.8, 94.7), respectively, with a specificity of 50.6% (95% CI: 30.4, 70.7) and 30.8% (95% CI: 21.5, 42.0), respectively. For TDA A, estimated sensitivity in children in high-risk groups was lower than those with low-risk (83.0%, 95% CI: 79.4%, 86.1%; versus 88.0%, 95% CI: 84.8%, 90.6%), while having a gain in specificity (50.0%, 95% CI: 44.9%, 55.1%; versus 36.6%, 95% CI: 32.7%, 40.7%). Trends were similar for TDA B. As for limitations, most diagnostic tuberculosis studies in children, including two of those included in the IPD, are performed at secondary or tertiary hospitals with higher levels of healthcare and thus the target population might differ somewhat from the IPD, potentially limiting the generalisability of our results. CONCLUSIONS: This retrospective external evaluation of WHO TDAs in a large IPD shows high sensitivity but sub-optimal specificity for both TDAs, in line with the meta-analyses that generated the algorithms. Prospective studies that evaluate the entire TDA, including triage step are needed. Additionally, the integration of novel diagnostic tools within the TDAs should aim to enhance the accuracy, especially the specificity. CI - Copyright: (c) 2025 Olbrich et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Olbrich, Laura AU - Olbrich L AUID- ORCID: 0000-0001-8881-4102 AD - Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany. AD - German Centre for Infection Research (DZIF), Partner Site Munich, Munich, Germany. AD - Fraunhofer Institute ITMP, Immunology, Infection and Pandemic Research, Munich, Germany. FAU - Larsson, Leyla AU - Larsson L AUID- ORCID: 0000-0003-4869-4630 AD - Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany. FAU - Dunbar, Rory AU - Dunbar R AUID- ORCID: 0000-0003-1852-5940 AD - Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. FAU - Dodd, Peter J AU - Dodd PJ AUID- ORCID: 0000-0001-5825-9347 AD - Sheffield Centre for Health and Related Research, School of Medicine and Population Health, Sheffield, United Kingdom. FAU - Palmer, Megan AU - Palmer M AUID- ORCID: 0000-0002-2534-2483 AD - Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. FAU - Huyen Ton Nu Nguyet, Minh AU - Huyen Ton Nu Nguyet M AD - Bordeaux Population Health, Inserm U1219, IRD EMR271, University of Bordeaux, Bordeaux, France. FAU - d'Elbee, Marc AU - d'Elbee M AD - Bordeaux Population Health, Inserm U1219, IRD EMR271, University of Bordeaux, Bordeaux, France. FAU - Hesseling, Anneke C AU - Hesseling AC AD - Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. FAU - Heinrich, Norbert AU - Heinrich N AUID- ORCID: 0000-0001-9252-7106 AD - Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany. AD - German Centre for Infection Research (DZIF), Partner Site Munich, Munich, Germany. AD - Fraunhofer Institute ITMP, Immunology, Infection and Pandemic Research, Munich, Germany. FAU - Zar, Heather J AU - Zar HJ AD - Department of Paediatrics & Child Health, Red Cross War Memorial Children's Hospital, MRC Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa. FAU - Ntinginya, Nyanda E AU - Ntinginya NE AD - NIMR - Mbeya Medical Research Centre, Mbeya, Tanzania. FAU - Khosa, Celso AU - Khosa C AUID- ORCID: 0000-0001-6701-4202 AD - Instituto Nacional de Saude (INS), Maputo, Mozambique. AD - Department of Physiological Science, Clinical Pharmacology, Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique. FAU - Nliwasa, Marriott AU - Nliwasa M AD - Kamuzu University of Health Sciences, Blantyre, Malawi. FAU - Verghese, Valsan P AU - Verghese VP AUID- ORCID: 0000-0001-6507-7795 AD - Pediatric Infectious Diseases, Christian Medical College, Vellore, India. FAU - Bonnet, Maryline AU - Bonnet M AUID- ORCID: 0000-0002-1071-7393 AD - TransVIHMI, University of Montpellier, Institut de Recherche pour le Developpement (IRD), Institut National de la Sante et Recherche Medicale (INSERM), Montpellier, France. FAU - Wobudeya, Eric AU - Wobudeya E AUID- ORCID: 0000-0001-9574-5539 AD - MU-JHU Care Ltd, Kampala, Uganda. FAU - Nduna, Bwendo AU - Nduna B AD - Arthur Davidson Children's Hospital, Ndola, Zambia. FAU - Moh, Raoul AU - Moh R AD - Programme PAC-CI, Abidjan, Cote d'Ivoire. FAU - Mwanga-Amumpere, Juliet AU - Mwanga-Amumpere J AUID- ORCID: 0000-0002-6738-477X AD - Epicentre Mbarara Research Centre, Mbarara, Uganda. FAU - Mustapha, Ayeshatu AU - Mustapha A AD - Ola During Children Hospital, Freetown, Sierra Leone. FAU - Breton, Guillaume AU - Breton G AD - Solthis, Paris, France. FAU - Taguebue, Jean-Voisin AU - Taguebue JV AD - Mother and Child Center-Chantal Biya Foundation, Yaounde, Cameroon. FAU - Borand, Laurence AU - Borand L AD - Epidemiology and Public Health Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia. AD - Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America. FAU - Chabala, Chishala AU - Chabala C AUID- ORCID: 0000-0002-5551-5752 AD - University of Zambia School of Medicine, University Teaching Hospital, Lusaka, Zambia. FAU - Marcy, Olivier AU - Marcy O AUID- ORCID: 0000-0003-3350-112X AD - Bordeaux Population Health, Inserm U1219, IRD EMR271, University of Bordeaux, Bordeaux, France. FAU - Seddon, James A AU - Seddon JA AUID- ORCID: 0000-0002-2296-2302 AD - Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. AD - Department of Infectious Disease, Imperial College London, London, United Kingdom. FAU - van der Zalm, Marieke M AU - van der Zalm MM AUID- ORCID: 0000-0002-8787-9139 AD - Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. CN - Decide-TB Study Group, the RaPaed-TB Consortium, the Umoya Study Group, and the TB Speed Consortium LA - eng GR - K43 TW011028/TW/FIC NIH HHS/United States PT - Journal Article PT - Meta-Analysis DEP - 20251118 PL - United States TA - PLoS Med JT - PLoS medicine JID - 101231360 RN - 0 (Antitubercular Agents) SB - IM MH - Humans MH - World Health Organization MH - *Algorithms MH - Child MH - Child, Preschool MH - Infant MH - Male MH - Retrospective Studies MH - Female MH - *Antitubercular Agents/therapeutic use MH - *Tuberculosis, Pulmonary/diagnosis/drug therapy MH - HIV Infections MH - Clinical Decision-Making MH - *Tuberculosis/diagnosis/drug therapy PMC - PMC12626314 COIS- I have read the journal's policy and the authors of this manuscript have the following competing interests: N.H. has received funding from Beckman Coulter for evaluation of a test, to his institution. EDAT- 2025/11/18 18:31 MHDA- 2025/11/18 18:32 PMCR- 2025/11/18 CRDT- 2025/11/18 13:24 PHST- 2025/03/04 00:00 [received] PHST- 2025/09/25 00:00 [accepted] PHST- 2025/11/18 18:32 [medline] PHST- 2025/11/18 18:31 [pubmed] PHST- 2025/11/18 13:24 [entrez] PHST- 2025/11/18 00:00 [pmc-release] AID - PMEDICINE-D-25-00818 [pii] AID - 10.1371/journal.pmed.1004610 [doi] PST - epublish SO - PLoS Med. 2025 Nov 18;22(11):e1004610. doi: 10.1371/journal.pmed.1004610. eCollection 2025 Nov. PMID- 41252324 OWN - NLM STAT- MEDLINE DCOM- 20260424 LR - 20260424 IS - 1878-6324 (Electronic) IS - 1053-8127 (Linking) VI - 39 IP - 3 DP - 2026 May TI - Prevalence and profile of low back pain and its associated factors among undergraduate medical students: A Jordanian cross-sectional study. PG - 844-852 LID - 10.1177/10538127251395489 [doi] AB - BackgroundWorldwide, medical students frequently have low back pain (LBP); the rigorous study schedules and training requirements of their program place them at increased risk.ObjectivesTo determine the prevalence and profile of LBP among medical students in Jordan, and to examine its associations with demographics, physical activity, and sleep quality.MethodsA cross-sectional study was conducted among 252 undergraduate medical students (63% female, aged 18-24 years, with a mean height of 1.7 +/- 0.1 m and a mean weight of 66.1 +/- 13.1 kg). Participants were recruited from public and private medical schools (February-April 2025). Data on LBP were collected (12-month prevalence, duration, impact, and associated symptoms). Widely validated instruments were used; the Nordic Musculoskeletal Questionnaire for assessing musculoskeletal symptoms, the International Physical Activity Questionnaire for evaluating physical activity levels, and the Sleep Quality Scale provides a measure of subjective sleep quality. Analyses were performed using IBM SPSS; chi-square and logistic regression were used to identify the associations between variables.ResultsThe 12-month prevalence of LBP was 69%, higher in females (72.3%) (p = 0.18). Basic-level students reported a significantly higher prevalence (76.1%) (p = 0.04). Among those with LBP, 48.3% reported activity limitations, and 79.3% reported poor sleep quality. Logistic regression identified academic level (OR = 0.489, p = 0.03) and poor sleep (OR = 2.207, p = 0.01) as predictors.ConclusionLBP is common among Jordanian medical students and is significantly associated with academic level and poor sleep. Promoting awareness of posture, exercise, and healthy sleep habits may help reduce the burden of LBP in this population. FAU - Salameh, Muna A AU - Salameh MA AUID- ORCID: 0000-0003-4836-9440 AD - Faculty of Medicine, Al Balqa Applied University, Al-Salt, Jordan. FAU - Odeh, Hadeel AU - Odeh H AD - Faculty of Medicine, Al Balqa Applied University, Al-Salt, Jordan. FAU - Shurrab, Ala'a M AU - Shurrab AM AUID- ORCID: 0009-0002-0997-2239 AD - Faculty of Medicine, Al Balqa Applied University, Al-Salt, Jordan. FAU - Alserhan, Hala A AU - Alserhan HA AUID- ORCID: 0009-0004-1022-9201 AD - Faculty of Medicine, Al Balqa Applied University, Al-Salt, Jordan. FAU - Sallam, Jwan I AU - Sallam JI AUID- ORCID: 0009-0003-6641-5436 AD - Faculty of Medicine, Al Balqa Applied University, Al-Salt, Jordan. FAU - Alshoa'ra, Farah G AU - Alshoa'ra FG AD - Faculty of Medicine, Al Balqa Applied University, Al-Salt, Jordan. FAU - Alkrarha, Yumna A AU - Alkrarha YA AUID- ORCID: 0009-0005-3242-3950 AD - Faculty of Medicine, Al Balqa Applied University, Al-Salt, Jordan. FAU - Abdulraheem, Sewar R AU - Abdulraheem SR AUID- ORCID: 0009-0006-5365-9775 AD - Faculty of Medicine, Al Balqa Applied University, Al-Salt, Jordan. FAU - Almashaqbeh, Mayah A AU - Almashaqbeh MA AUID- ORCID: 0009-0001-5833-9993 AD - Faculty of Medicine, Al Balqa Applied University, Al-Salt, Jordan. LA - eng PT - Journal Article DEP - 20251118 PL - United States TA - J Back Musculoskelet Rehabil JT - Journal of back and musculoskeletal rehabilitation JID - 9201340 SB - IM MH - Humans MH - Female MH - Jordan/epidemiology MH - *Low Back Pain/epidemiology MH - Cross-Sectional Studies MH - *Students, Medical/statistics & numerical data MH - Prevalence MH - Male MH - Young Adult MH - Adolescent MH - Surveys and Questionnaires MH - Exercise MH - Risk Factors MH - Sleep Quality OTO - NOTNLM OT - epidemiology OT - low back pain OT - medical students OT - physical activity OT - sleep quality COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/11/18 18:31 MHDA- 2026/04/24 06:33 CRDT- 2025/11/18 13:23 PHST- 2026/04/24 06:33 [medline] PHST- 2025/11/18 18:31 [pubmed] PHST- 2025/11/18 13:23 [entrez] AID - 10.1177/10538127251395489 [doi] PST - ppublish SO - J Back Musculoskelet Rehabil. 2026 May;39(3):844-852. doi: 10.1177/10538127251395489. Epub 2025 Nov 18. PMID- 41252169 OWN - NLM STAT- MEDLINE DCOM- 20251118 LR - 20260725 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 8 IP - 11 DP - 2025 Nov 3 TI - Evaluation of a State-Level Incentive Program to Improve Diet. PG - e2544215 LID - 10.1001/jamanetworkopen.2025.44215 [doi] LID - e2544215 AB - IMPORTANCE: Fruit and vegetable incentive programs show promise for improving dietary quality among Supplemental Nutrition Assistance Program (SNAP) participants, but few programs have been implemented at scale. Understanding state-level program effectiveness is critical for informing nutrition assistance policy. OBJECTIVE: To evaluate the association of Eat Well, Be Well (EWBW), the first state-level SNAP fruit and vegetable incentive program launched in Rhode Island, with dietary intake and program awareness during initial implementation. DESIGN, SETTING, AND PARTICIPANTS: In this pre-post cohort study with a comparison site (Connecticut) using difference-in-differences analysis, baseline data were collected from May 15 to September 30, 2023, with follow-up from June 12 to October 6, 2024 (5-8 months after implementation). Community-based recruitment took place across Rhode Island (intervention) and Connecticut (comparison), including food pantries and health fairs, as well as via text messages sent to participants from the Special Supplemental Nutrition Program for Women, Infants, and Children. Participants were current SNAP recipients, aged 18 years or older, English or Spanish speaking and had email or text access. INTERVENTION: Automatic enrollment providing a $0.50 credit per $1 spent on fresh fruits and vegetables (up to $25/mo) at 2 grocery chains, with credits deposited on Electronic Benefits Transfer cards. MAIN OUTCOMES AND MEASURES: The primary outcome was change in total fruit and vegetable intake (measured as cup equivalents per 1000 kcal) via validated food frequency questionnaire. Secondary outcomes included diet quality (measured by the Healthy Eating Index-2015), program awareness, and use of the program. RESULTS: Of the 725 participants (mean [SD] baseline age, 34.5 [10.1] years; 364 in Rhode Island and 361 in Connecticut), 690 were women (95.2%), and the mean (SD) household size was 3.9 (1.6) at baseline and follow-up. Baseline mean (SD) fruit and vegetable intake was 2.05 (1.19) cup equivalents per 1000 kcal in Rhode Island and 2.12 (1.25) cup equivalents per 1000 kcal in Connecticut. There was no significant change in fruit and vegetable intake in Rhode Island relative to Connecticut (0.12 [95% CI, -0.04 to 0.28] cup equivalents per 1000 kcal). Stratified analyses among those with higher baseline consumption of fruits and vegetables (>1.79 cup equivalents/1000 kcal) showed that fruit and vegetable intake significantly increased in Rhode Island relative to Connecticut (0.29 [95% CI, 0.03-0.54] cup equivalents per 1000 kcal), while those with lower baseline consumption of fruits and vegetables showed no change (0.00 [95% CI, -0.17 to 0.18] cup equivalents per 1000 kcal). A total of 134 of 364 Rhode Island respondents (36.8%) correctly identified the program's purpose and 96 of 364 (26.4%) reported using discounts available through the EWBW. CONCLUSIONS AND RELEVANCE: In this cohort study of SNAP participants, the 50% incentive, automatic enrollment EWBW program was not associated with significant relative changes in fruit and vegetable intake, but was associated with benefits among participants already consuming more fruits and vegetables. Enhanced implementation, including broader retail partnerships, improved outreach, and targeted interventions for populations with lower intake of fruits and vegetables, may be needed to maximize public health outcomes. FAU - Tovar, Alison AU - Tovar A AD - Department of Behavioral and Social Sciences, School of Public Health, Brown University, Providence, Rhode Island. FAU - Powell, Lisa M AU - Powell LM AD - Division of Health Policy and Administration, School of Public Health, University of Illinois Chicago. FAU - Leider, Julien AU - Leider J AD - Institute for Health Research and Policy, School of Public Health, University of Illinois Chicago. FAU - Elenio, Emily AU - Elenio E AD - Department of Behavioral and Social Sciences, School of Public Health, Brown University, Providence, Rhode Island. FAU - Oddo, Vanessa M AU - Oddo VM AD - Department of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois Chicago. FAU - Vadiveloo, Maya K AU - Vadiveloo MK AD - Department of Nutrition, College of Health Sciences, The University of Rhode Island, Kingston. LA - eng GR - K01 HL165104/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251103 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Humans MH - Female MH - *Food Assistance/statistics & numerical data MH - Male MH - Rhode Island MH - Adult MH - Vegetables MH - *Motivation MH - Fruit MH - Program Evaluation MH - Middle Aged MH - Connecticut MH - *Diet, Healthy MH - *Health Promotion/methods MH - *Diet MH - Cohort Studies PMC - PMC12628101 COIS- Conflict of Interest Disclosures: None reported. EDAT- 2025/11/18 12:28 MHDA- 2025/11/18 18:30 PMCR- 2025/11/18 CRDT- 2025/11/18 11:33 PHST- 2025/11/18 18:30 [medline] PHST- 2025/11/18 12:28 [pubmed] PHST- 2025/11/18 11:33 [entrez] PHST- 2025/11/18 00:00 [pmc-release] AID - 2841543 [pii] AID - zoi251195 [pii] AID - 10.1001/jamanetworkopen.2025.44215 [doi] PST - epublish SO - JAMA Netw Open. 2025 Nov 3;8(11):e2544215. doi: 10.1001/jamanetworkopen.2025.44215. PMID- 41251629 OWN - NLM STAT- MEDLINE DCOM- 20260502 LR - 20260502 IS - 1532-656X (Electronic) IS - 0891-5245 (Linking) VI - 40 IP - 3 DP - 2026 May-Jun TI - Validation of Four Malnutrition Risk Screening Tools (PNST, PYMS, STAMP, and STRONGkids) for Hospitalized Children. PG - 385-394 LID - S0891-5245(25)00307-4 [pii] LID - 10.1016/j.pedhc.2025.09.021 [doi] AB - INTRODUCTION: Early detection of malnutrition in hospitalized children is crucial for reducing hospital stays and improving outcomes. This study evaluates the effectiveness of four pediatric nutritional screening tools-PNST, PYMS, STAMP, and STRONGkids-in a pediatric hospital setting. METHODS: A cross-sectional study assessed 200 pediatric patients, comparing each tool against SGNA and AND/ASPEN criteria. RESULTS: STAMP demonstrated the highest sensitivity (91.3%) and specificity (76.3%), with strong predictive values. It also had the highest agreement rate (86.5%) and a Kappa value of 0.7. STRONGkids followed with a 78% agreement and a Kappa value of 0.6, while PNST and PYMS showed lower agreement (75%, Kappa = 0.5). DISCUSSION: STAMP is the most effective tool for detecting undernutrition in pediatric patients, supporting timely interventions and improved health outcomes. Integrating STAMP into pediatric care can enhance nutritional management and reduce hospital stays. CI - Copyright (c) 2025 National Association of Pediatric Nurse Practitioners. Published by Elsevier Inc. All rights reserved. FAU - Luu, Thi My Thuc AU - Luu TMT AD - Thi My Thuc Luu, Viet Nam National Children's Hospital, Dong Da, Hanoi, Vietnam. FAU - Nguyen, Thi Thu Lieu AU - Nguyen TTL AD - Thi Thu Lieu Nguyen, Thu Huyen Doan, Thi Huong Le, Thi Thanh Xuan Le, Institute of Preventive Medicine and Public Health, Hanoi Medical University, Dong Da, Hanoi, Vietnam; Thi Thu Lieu Nguyen, National Hospital of Obstetrics and Gynecology, Hoan Kiem, Hanoi, Vietnam. Electronic address: nguyenthulieu@hmu.edu.vn. FAU - Doan, Thu Huyen AU - Doan TH AD - Thi Thu Lieu Nguyen, Thu Huyen Doan, Thi Huong Le, Thi Thanh Xuan Le, Institute of Preventive Medicine and Public Health, Hanoi Medical University, Dong Da, Hanoi, Vietnam. FAU - Duong, Thi Phuong AU - Duong TP AD - Thi Phuong Duong, Hanoi Medical University Hospital, Dong Da, Hanoi, Vietnam. FAU - Le, Thi Huong AU - Le TH AD - Thi Thu Lieu Nguyen, Thu Huyen Doan, Thi Huong Le, Thi Thanh Xuan Le, Institute of Preventive Medicine and Public Health, Hanoi Medical University, Dong Da, Hanoi, Vietnam. FAU - Le, Thi Thanh Xuan AU - Le TTX AD - Thi Thu Lieu Nguyen, Thu Huyen Doan, Thi Huong Le, Thi Thanh Xuan Le, Institute of Preventive Medicine and Public Health, Hanoi Medical University, Dong Da, Hanoi, Vietnam. LA - eng PT - Journal Article PT - Validation Study DEP - 20251118 PL - United States TA - J Pediatr Health Care JT - Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners JID - 8709735 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Female MH - Child, Preschool MH - *Child, Hospitalized MH - *Nutrition Assessment MH - *Mass Screening/methods MH - Infant MH - *Malnutrition/diagnosis MH - Child MH - Sensitivity and Specificity MH - Risk Assessment MH - Hospitalization MH - *Child Nutrition Disorders/diagnosis MH - Reproducibility of Results MH - Hospitals, Pediatric OTO - NOTNLM OT - Hospitalized children OT - malnutrition OT - screening tools OT - validation COIS- CONFLICTS OF INTEREST None to report. EDAT- 2025/11/18 12:29 MHDA- 2026/05/03 05:27 CRDT- 2025/11/18 10:27 PHST- 2025/03/28 00:00 [received] PHST- 2025/09/24 00:00 [revised] PHST- 2025/09/27 00:00 [accepted] PHST- 2026/05/03 05:27 [medline] PHST- 2025/11/18 12:29 [pubmed] PHST- 2025/11/18 10:27 [entrez] AID - S0891-5245(25)00307-4 [pii] AID - 10.1016/j.pedhc.2025.09.021 [doi] PST - ppublish SO - J Pediatr Health Care. 2026 May-Jun;40(3):385-394. doi: 10.1016/j.pedhc.2025.09.021. Epub 2025 Nov 18. PMID- 41250678 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251118 LR - 20251120 IS - 1687-8728 (Print) IS - 1687-8736 (Electronic) IS - 1687-8728 (Linking) VI - 2025 DP - 2025 TI - The Impact of Overweight Among Children on Salivary Vitamin D, Calcium, and Magnesium in Relation to Dental Caries Severity. PG - 4220296 LID - 10.1155/ijod/4220296 [doi] LID - 4220296 AB - Vitamin D is one of several nutrients essential for calcium metabolism. Body weight status and magnesium may influence vitamin D activity. To determine whether salivary vitamin D, magnesium, and calcium levels are associated with body weight status and dental caries severity in children, this cross-sectional research was conducted. METHODS: The sample consisted of 180 boys aged 6-8 years. According to their body mass index (BMI), children were assigned to three groups of 60 boys (normal weight, overweight, and obese). Moreover, within each weight group, the sample was divided into three groups according to caries severity (20 children in each group): mild (dmft /= 7). Unstimulated whole saliva was obtained from each child in the morning (9 : 00-11 : 00 a.m.) at least 1 h after food or drink intake. Participants were seated and asked to accumulate saliva in the floor of their mouth and then spit into sterile, prelabeled polypropylene tubes over a 5 min period; the samples were then analyzed to assess salivary vitamin D, calcium, and magnesium concentrations. RESULTS: Salivary vitamin D, calcium, and magnesium concentrations were significantly higher in boys with normal weight than in overweight and obese boys (p 0.05). These findings indicate that pro-inflammatory dietary patterns are associated with worsened inflammatory markers, glycemic control, and gonadotropin levels in women with PCOS. The results suggest a possible beneficial role of anti-inflammatory dietary interventions in PCOS management, although longitudinal studies are needed to establish causal relationships. CI - (c) 2025. The Author(s). FAU - Morshedzadeh, Nava AU - Morshedzadeh N AD - Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran. AD - Department of Nutrition, Faculty of Public Health, Kerman University of Medical Sciences, PO Box: 7616913555, Kerman, Iran. FAU - Behrouz, Vahideh AU - Behrouz V AD - Department of Nutrition, Faculty of Public Health, Kerman University of Medical Sciences, PO Box: 7616913555, Kerman, Iran. vahideh.behrouz@gmail.com. FAU - Ahmadi, Amirhossein Ramezani AU - Ahmadi AR AD - Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. LA - eng PT - Journal Article DEP - 20251117 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Biomarkers) RN - 9002-67-9 (Luteinizing Hormone) RN - 9007-41-4 (C-Reactive Protein) RN - 9002-68-0 (Follicle Stimulating Hormone) RN - 0 (Hormones) RN - 3XMK78S47O (Testosterone) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - Female MH - Adult MH - *Polycystic Ovary Syndrome/metabolism/blood MH - Cross-Sectional Studies MH - *Inflammation/metabolism/blood MH - Young Adult MH - Middle Aged MH - Adolescent MH - *Diet/adverse effects MH - Biomarkers/blood MH - Luteinizing Hormone/blood MH - C-Reactive Protein/metabolism MH - Follicle Stimulating Hormone/blood MH - *Hormones/blood MH - Testosterone/blood MH - Blood Glucose/metabolism MH - Body Mass Index MH - *Metabolome PMC - PMC12623732 OTO - NOTNLM OT - Dietary inflammatory index OT - Dyslipidemia OT - Glycemic control OT - Hyperandrogenism OT - Inflammation OT - Obesity OT - PCOS COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Research Ethics Committee of Kerman University of Medical Sciences, under protocol number IR.KMU.REC.1400.009. All participants provided written informed consent and were informed about the study. All procedures performed in studies involving human participants adhered to the ethical standards of the institutional and/or national research committee and to the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Competing interests: The authors declare no competing interests. EDAT- 2025/11/18 00:28 MHDA- 2025/11/18 00:29 PMCR- 2025/11/17 CRDT- 2025/11/17 23:36 PHST- 2025/05/07 00:00 [received] PHST- 2025/10/10 00:00 [accepted] PHST- 2025/11/18 00:29 [medline] PHST- 2025/11/18 00:28 [pubmed] PHST- 2025/11/17 23:36 [entrez] PHST- 2025/11/17 00:00 [pmc-release] AID - 10.1038/s41598-025-24046-z [pii] AID - 24046 [pii] AID - 10.1038/s41598-025-24046-z [doi] PST - epublish SO - Sci Rep. 2025 Nov 17;15(1):40211. doi: 10.1038/s41598-025-24046-z. PMID- 41247430 OWN - NLM STAT- MEDLINE DCOM- 20260206 LR - 20260920 IS - 1179-1926 (Electronic) IS - 0312-5963 (Print) IS - 0312-5963 (Linking) VI - 65 IP - 2 DP - 2026 Feb TI - Population Pharmacokinetic Modeling of Oxcarbazepine and Its Active Metabolite 10-Monohydroxy Derivative to Inform Dosing in Children with Obesity. PG - 329-344 LID - 10.1007/s40262-025-01579-0 [doi] AB - BACKGROUND: Oxcarbazepine (OXZ) is an antiepileptic drug whose pharmacological effect is primarily mediated by its active metabolite, 10-monohydroxy derivative (MHD). OXZ is approved for use in adults and children older than 2 years with an age- and body weight-tiered dosing recommendation, but dosing guidance for children with obesity is lacking. OBJECTIVE: This work aimed to assess the dosing requirements of OXZ in children with obesity to support label extension. METHODS: Two multicenter studies (NCT01431326 and NCT02993861) were conducted in patients receiving standard-of-care OXZ therapy. Participants >/= 2 years of age with a body mass index >/= 95th percentile were classified as obese. Plasma concentrations were measured by a validated liquid chromatography tandem mass spectrometry (LC-MS/MS) assay. Nonlinear mixed effects modeling was performed using NONMEM 7.4 to characterize the population pharmacokinetics of OXZ and MHD simultaneously. Simulations were performed to compare MHD systemic exposure in children >/= 2 years of age with and without obesity. RESULTS: One hundred study participants with a median (range) age of 9 years (44 days-20.90 years) contributed 425 plasma concentrations of OXZ (n = 212) and MHD (n = 213). Fifty-two percent of the participants had obesity. A one-compartment joint parent-metabolite model with linear input-output and bi-directional transformation between OXZ and MHD best characterized the pharmacokinetics. Body size was the only covariate affecting pharmacokinetics, and a fat-free mass-based metric termed pharmacokinetic weight (PKWT) best characterized that effect allometrically. Simulation results revealed that the current dosing regimen of OXZ can produce comparable exposure of MHD in children >/= 2 years of age with and without obesity. CONCLUSION: A model-informed analysis confirms that the current pediatric dosing regimen of OXZ applies to children in general, regardless of their obesity status. CI - (c) 2025. The Author(s). FAU - Sinha, Jaydeep AU - Sinha J AUID- ORCID: 0000-0002-2110-3370 AD - Department of Pediatrics, UNC School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. FAU - Zimmerman, Kanecia AU - Zimmerman K AUID- ORCID: 0000-0003-3748-6932 AD - Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA. AD - Duke Clinical Research Institute, Durham, NC, USA. FAU - Balevic, Stephen J AU - Balevic SJ AUID- ORCID: 0000-0002-4016-1680 AD - Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA. AD - Duke Clinical Research Institute, Durham, NC, USA. AD - Department of Medicine, Duke University School of Medicine, PO Box 17969, Durham, NC, 27715, USA. FAU - Hornik, Chi AU - Hornik C AUID- ORCID: 0000-0002-7656-3657 AD - Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA. AD - Duke Clinical Research Institute, Durham, NC, USA. FAU - Muller, William J AU - Muller WJ AUID- ORCID: 0000-0001-7690-0695 AD - Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA. FAU - Rathore, Mobeen AU - Rathore M AUID- ORCID: 0000-0001-7416-9755 AD - Jacksonville Shands Medical Center, University of Florida Center for HIV/AIDS Research, Education and Service (UF CARES), Jacksonville, FL, USA. FAU - Meyer, Marisa AU - Meyer M AUID- ORCID: 0009-0005-8400-5187 AD - Division of Critical Care, Department of Pediatrics, Nemours Children's Hospital, Wilmington, DE, USA. AD - Department of Pediatrics, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA. FAU - Finkelstein, Yaron AU - Finkelstein Y AUID- ORCID: 0000-0002-0947-3571 AD - The Hospital for Sick Children, Toronto, Ontario, Canada. FAU - Al-Uzri, Amira AU - Al-Uzri A AUID- ORCID: 0000-0001-6532-7117 AD - Oregon Health and Science University, Portland, OR, USA. FAU - Lakhotia, Arpita AU - Lakhotia A AUID- ORCID: 0000-0003-2948-4531 AD - University of Louisville Norton Children's Medical Group, Louisville, KY, USA. FAU - Goldstein, Stuart AU - Goldstein S AUID- ORCID: 0000-0003-3711-8785 AD - Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. FAU - Chen, Jia-Yuh AU - Chen JY AUID- ORCID: 0000-0002-5736-5970 AD - The Emmes Company, LLC, Rockville, MD, USA. FAU - Anand, Ravinder AU - Anand R AUID- ORCID: 0000-0001-8628-2130 AD - The Emmes Company, LLC, Rockville, MD, USA. FAU - Gonzalez, Daniel AU - Gonzalez D AUID- ORCID: 0000-0001-5522-5686 AD - Duke Clinical Research Institute, Durham, NC, USA. daniel.gonzalez@duke.edu. AD - Department of Medicine, Duke University School of Medicine, PO Box 17969, Durham, NC, 27715, USA. daniel.gonzalez@duke.edu. CN - Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee LA - eng SI - ClinicalTrials.gov/NCT01431326 SI - ClinicalTrials.gov/NCT02993861 SI - ClinicalTrials.gov/NCT02993861 SI - ClinicalTrials.gov/NCT01431326 GR - R01HD096435/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ GR - R01 HD102949/HD/NICHD NIH HHS/United States GR - UL1 TR002369/TR/NCATS NIH HHS/United States GR - R01 HD096435/HD/NICHD NIH HHS/United States GR - HHSN275201000003C/HD/NICHD NIH HHS/United States GR - HHSN275201000003I/HD/NICHD NIH HHS/United States GR - R01 HD113201/HD/NICHD NIH HHS/United States PT - Journal Article PT - Multicenter Study PT - Research Support, N.I.H., Extramural DEP - 20251117 PL - Switzerland TA - Clin Pharmacokinet JT - Clinical pharmacokinetics JID - 7606849 RN - VZI5B1W380 (Oxcarbazepine) RN - 0 (Anticonvulsants) RN - 33CM23913M (Carbamazepine) SB - IM EIN - Clin Pharmacokinet. 2026 Feb;65(2):345. doi: 10.1007/s40262-025-01613-1. PMID: 41493701 MH - Humans MH - *Oxcarbazepine/pharmacokinetics/administration & dosage/blood MH - Child MH - Male MH - Child, Preschool MH - *Anticonvulsants/pharmacokinetics/administration & dosage/blood MH - Female MH - *Models, Biological MH - Adolescent MH - *Pediatric Obesity/metabolism/blood MH - *Carbamazepine/pharmacokinetics/analogs & derivatives/administration & dosage/blood MH - Tandem Mass Spectrometry/methods MH - Chromatography, Liquid MH - Body Mass Index PMC - PMC12746435 MID - NIHMS2109798 COIS- Declarations. Conflict of Interest: The authors have no relevant conflicts of interest to disclose. Disclosures: JS's affiliation reflects the institution with which he was associated at the time this work was performed. SB receives support from the NIH and the Childhood Arthritis and Rheumatology Research Alliance, has done consulting work for UCB and Rutgers University, and serves on an NIH Data and Safety Monitoring Board. DG receives support from the Eunice Kennedy Shriver NICHD (R01HD096435, R01HD102949, R01HD113201, and HHSN275201000003I) and other sponsors for drug development in adults and children ( https://dcri.org/about-us/conflict-of-interest/ ). DG is an Editorial Board member of Clinical Pharmacokinetics. DG was not involved in the selection of peer reviewers for the manuscript nor any of the subsequent editorial decisions. Availability of Data and Material: To help expand the knowledge base for pediatric medicine, the PTN is pleased to share data from its completed and published studies with interested investigators. For requests, please contact PTN-Program-Manager@dm.duke.edu. Ethics Approval: The AED01 study was approved by the Duke Health Institutional Review Board (IRB) under IRB number Pro0007092, and the POP01 study was approved under IRB number Pro00029638. Consent to Participate: Informed consent and assent, when applicable, were obtained from all participants enrolled in the studies that facilitated the collection of oxcarbazepine data. Consent for Publication: Not applicable. Code Availability: The NONMEM code for the final population PK model is provided in the electronic supplementary material (see ESM2). Authors' Contributions: Participated in research design: JS, KZ, SB, and DG. Performed the research: JS, KZ, SB, CH, WM, MR, MM, YF, AA-U, AL, SG, J-YC, RA, and DG. Performed the data analysis: JS and DG. Wrote or contributed to the writing of the manuscript: JS, KZ, SB, CH, WM, MR, MM, YF, AA-U, AL, SG, J-YC, RA, and DG. FIR - Benjamin, Daniel K Jr IR - Benjamin DK Jr FIR - Kennel, Phyllis IR - Kennel P FIR - Alderman, Cheryl IR - Alderman C FIR - Sund, Zoe IR - Sund Z FIR - Opel, Kylie IR - Opel K FIR - Beci, Rose IR - Beci R FIR - Hornik, Chi Dang IR - Hornik CD FIR - Kearns, Gregory L IR - Kearns GL FIR - Laughon, Matthew IR - Laughon M FIR - Paul, Ian M IR - Paul IM FIR - Sullivan, Janice IR - Sullivan J FIR - Wade, Kelly IR - Wade K FIR - Delmore, Paula IR - Delmore P FIR - West, Leanne IR - West L FIR - Payne, Elizabeth IR - Payne E FIR - Chen, Lily IR - Chen L FIR - Simone, Gina IR - Simone G FIR - O'Connor, Kathleen IR - O'Connor K FIR - Cermak, Jennifer IR - Cermak J FIR - Taylor, Lawrence IR - Taylor L FIR - Green, Thomas IR - Green T FIR - Benjamin, Danny IR - Benjamin D FIR - Taylor-Zapata, Perdita IR - Taylor-Zapata P FIR - Wade, Kelly IR - Wade K FIR - Kearns, Greg IR - Kearns G FIR - Paul, Ian IR - Paul I FIR - Autmizguine, Julie IR - Autmizguine J FIR - Capparelli, Edmund IR - Capparelli E FIR - Greenberg, Rachel IR - Greenberg R FIR - Alderman, Cheryl IR - Alderman C FIR - Green, Terren IR - Green T FIR - John, Ramany IR - John R FIR - Muller, William IR - Muller W FIR - Yogev, Ram IR - Yogev R FIR - Fearn, Laura IR - Fearn L FIR - Taravath, Sasidharan IR - Taravath S FIR - Blanks, Tiffony IR - Blanks T FIR - Lapid, Arielle IR - Lapid A FIR - Harward, Melissa IR - Harward M FIR - Baisden, Nicole IR - Baisden N FIR - Clark, Kira IR - Clark K FIR - Craven, Sarah IR - Craven S FIR - Grzesek, Kimberly IR - Grzesek K FIR - Joshi, Charuta IR - Joshi C FIR - Drake, Austin IR - Drake A FIR - Filar, Lauri IR - Filar L FIR - Sargent, Jennifer IR - Sargent J FIR - Oldham, Michael IR - Oldham M FIR - Burmester, Julie IR - Burmester J FIR - Eubanks, Stephany IR - Eubanks S FIR - Simeon, Terri IR - Simeon T FIR - Shiloh-Malawsky, Yael IR - Shiloh-Malawsky Y FIR - Anderson, Christopher IR - Anderson C FIR - Jolly, Mallory IR - Jolly M FIR - Joshi, Shradhdha IR - Joshi S FIR - Odero, Norbert IR - Odero N FIR - Taylor, Jennifer IR - Taylor J FIR - Arnold, Susan IR - Arnold S FIR - Harper, Caryn IR - Harper C FIR - Howard, Erica IR - Howard E FIR - Martinez, Maria IR - Martinez M FIR - Myer, Deanna IR - Myer D FIR - Walker, Angela IR - Walker A FIR - DeGrauw, Ton IR - DeGrauw T FIR - Benoit, Macarthur IR - Benoit M FIR - Sims, Christopher IR - Sims C FIR - Muller, William IR - Muller W FIR - Yogev, Ram IR - Yogev R FIR - Fearn, Laura IR - Fearn L FIR - Traisman, Benjamin IR - Traisman B FIR - Sroka, Pam IR - Sroka P FIR - Nielsen, Carol IR - Nielsen C FIR - Watt, Kevin IR - Watt K FIR - Baisden, Nicole IR - Baisden N FIR - Milleson, Christie IR - Milleson C FIR - Wrenn, Samantha IR - Wrenn S FIR - Mahmoudi, Kathleen Thoma Saniyyah IR - Mahmoudi KTS FIR - Riaz, Amna IR - Riaz A FIR - Borges, Alexandrea IR - Borges A FIR - James, Laura IR - James L FIR - Hansberry, Dawn IR - Hansberry D FIR - Hart, Michelle IR - Hart M FIR - Howard, Lee IR - Howard L FIR - Ann, D Pierce IR - Ann DP FIR - Sullivan, Janice IR - Sullivan J FIR - Kernen, Karrie IR - Kernen K FIR - Poff, Susan IR - Poff S FIR - Konow, Courtney IR - Konow C FIR - Brown, Kelli IR - Brown K FIR - Comings, Jen IR - Comings J FIR - Michael, Andrew IR - Michael A FIR - Perry, Jackie IR - Perry J FIR - Wiseheart, Michelle IR - Wiseheart M FIR - Laughon, Matthew IR - Laughon M FIR - Bernhardt, Janice IR - Bernhardt J FIR - Mariconti, Ashley IR - Mariconti A FIR - Talbert, Jennifer IR - Talbert J FIR - Stryjewski, Glenn IR - Stryjewski G FIR - John, Ramany IR - John R FIR - Kowal, Karen IR - Kowal K FIR - Klipner, Kimberly IR - Klipner K FIR - Rumantir, Maggie IR - Rumantir M FIR - Bradley, Gary IR - Bradley G FIR - Gerhardt, Bradley IR - Gerhardt B FIR - Kirby, Cassie IR - Kirby C FIR - DePaoli, Bradley IR - DePaoli B FIR - Arnold, Patricia IR - Arnold P FIR - Terrell, Tara IR - Terrell T FIR - Mottes, Theresa IR - Mottes T FIR - Pohl, Daniela IR - Pohl D FIR - McMilan, Hugh IR - McMilan H FIR - Zemek, Roger IR - Zemek R FIR - Lacaze, Thierry IR - Lacaze T FIR - Leradi, Sara IR - Leradi S FIR - Tuttle, Angie IR - Tuttle A FIR - Murchison, Barbara IR - Murchison B FIR - Patubo, Kyle IR - Patubo K FIR - Swanson, Connie IR - Swanson C FIR - Farrar, Carrie IR - Farrar C FIR - Kuchler, Andrea IR - Kuchler A FIR - Stubbs, Jennifer IR - Stubbs J FIR - Clark, Kira IR - Clark K FIR - Craven, Sarah IR - Craven S FIR - Grzesek, Kimberly IR - Grzesek K FIR - Lattimore, Susan IR - Lattimore S FIR - Mourani, Peter IR - Mourani P FIR - Goldenberg, Neil IR - Goldenberg N FIR - Van, Kevin IR - Van K FIR - Rutebemberwa, Alleluiah IR - Rutebemberwa A FIR - Sierra, Yamila IR - Sierra Y FIR - Malone, Kathryn IR - Malone K FIR - Deschenes, Jendar IR - Deschenes J FIR - Steinbeiss, Matthew IR - Steinbeiss M FIR - Ralston, Kimberly IR - Ralston K FIR - Hastenson, Gentle IR - Hastenson G FIR - DiDomenico, Domninic IR - DiDomenico D FIR - Dix, Megan IR - Dix M FIR - Autmizguine, Julie IR - Autmizguine J FIR - Litalien, Catherine IR - Litalien C FIR - Lague, Vincent IR - Lague V FIR - Dumitrascu, Mariana IR - Dumitrascu M FIR - Desmarasis, Diane IR - Desmarasis D FIR - Massicotte, Christine IR - Massicotte C EDAT- 2025/11/17 17:29 MHDA- 2026/02/06 14:37 PMCR- 2025/11/17 CRDT- 2025/11/17 11:04 PHST- 2025/01/29 00:00 [received] PHST- 2025/09/05 00:00 [accepted] PHST- 2026/02/06 14:37 [medline] PHST- 2025/11/17 17:29 [pubmed] PHST- 2025/11/17 11:04 [entrez] PHST- 2025/11/17 00:00 [pmc-release] AID - 10.1007/s40262-025-01579-0 [pii] AID - 1579 [pii] AID - 10.1007/s40262-025-01579-0 [doi] PST - ppublish SO - Clin Pharmacokinet. 2026 Feb;65(2):329-344. doi: 10.1007/s40262-025-01579-0. Epub 2025 Nov 17. PMID- 41246060 OWN - NLM STAT- MEDLINE DCOM- 20251117 LR - 20251120 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Dual-pathway protection: physical activity buffers the relationship between perceived stress and problematic smartphone use via social anxiety by a moderated mediation model in Chinese college students. PG - 1681556 LID - 10.3389/fpubh.2025.1681556 [doi] LID - 1681556 AB - OBJECTIVE: This study investigates the dual-pathway mechanism through which physical activity mitigates problematic smartphone use (PSU) among Chinese college students, examining the mediating role of social anxiety and the moderating effects of physical activity within a stress-PSU framework. METHODS: General stress theory was introduced to explore the intrinsic mechanisms by which perceived stress influences PSU. A total of 2,905 undergraduate students from universities in Shandong Province were selected using a convenient sampling method. Validated scales were used to measure perceived stress (PSS-14), social anxiety (IAS), physical activity (PARS-3) and PSU tendency (MPATS). Data analysis included correlation tests, regression analysis and moderated mediation modeling (PROCESS Macro Model 4/15). RESULTS: (1) There was a significant positive correlation between perceived stress, social anxiety and problematic smartphone use (All P < 0.01). Significant gender differences were found in social anxiety (P < 0.001) and problematic smartphone use (P < 0.05). (2) Path analysis revealed: A significant direct effect of perceived stress on PSU (beta = 0.537, 95%CI[0.490, 0.586]), accounting for 70.94% of the total effect. Social anxiety mediated 29.06% of the effect (indirect effect = 0.220, 95%CI[0.195, 0.244]). (3) Physical activity demonstrated dual moderating effects: Buffered the direct stress-PSU pathway (beta = -0.005, P < 0.001). Attenuated the social anxiety-PSU association (interaction beta = 0.002, P < 0.05). CONCLUSION: Physical activity disrupts the stress-PSU cycle through two synergistic mechanisms: directly reducing stress-driven addiction and decoupling social anxiety from excessive smartphone use. Universities should implement structured physical activity programs as a dual-path intervention against PSU. CI - Copyright (c) 2025 Liu, Han, Dai and Zhang. FAU - Liu, Ningning AU - Liu N AD - College of Basic Medical Sciences, Jining Medical University, Jining, China. FAU - Han, Xiaoyuan AU - Han X AD - Department of Psychology, Chengde Medical University, Chengde, Hebei, China. FAU - Dai, Xinghong AU - Dai X AD - School of Physical Education, Hunan University, Changsha, China. FAU - Zhang, Guofeng AU - Zhang G AD - Basic Department, Jining Polytechnic, Jining, China. LA - eng PT - Journal Article DEP - 20251030 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Students/psychology/statistics & numerical data MH - Male MH - Female MH - *Stress, Psychological/psychology MH - *Smartphone/statistics & numerical data MH - *Exercise/psychology MH - Universities MH - China MH - Young Adult MH - *Anxiety/psychology MH - Surveys and Questionnaires MH - Adult MH - Adolescent MH - *Internet Addiction Disorder/psychology MH - Mediation Analysis PMC - PMC12611824 OTO - NOTNLM OT - a moderated mediation model OT - college students OT - perceived stress OT - physical activity OT - problematic smartphone use OT - social anxiety COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/11/17 17:30 MHDA- 2025/11/17 17:31 PMCR- 2025/10/30 CRDT- 2025/11/17 06:25 PHST- 2025/08/07 00:00 [received] PHST- 2025/10/13 00:00 [accepted] PHST- 2025/11/17 17:31 [medline] PHST- 2025/11/17 17:30 [pubmed] PHST- 2025/11/17 06:25 [entrez] PHST- 2025/10/30 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1681556 [doi] PST - epublish SO - Front Public Health. 2025 Oct 30;13:1681556. doi: 10.3389/fpubh.2025.1681556. eCollection 2025. PMID- 41245646 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251117 LR - 20251120 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 7 DP - 2025 TI - A lifestyle-based prediction model for obesity in Chinese adolescent students. PG - 1677707 LID - 10.3389/fspor.2025.1677707 [doi] LID - 1677707 AB - INTRODUCTION: Adolescent obesity has emerged as a critical global public health challenge, necessitating effective tools for early identification and intervention. This study aimed to identify significant contributing factors and develop a predictive model for adolescent obesity using machine learning algorithms. METHODS: An anonymised dataset of 2,338 adolescents was utilised, incorporating variables related to family factors, lifestyle behaviours, and physical fitness scores. Variable selection was performed using LASSO regression with k-fold cross-validation, followed by parameter estimation via logistic regression. The optimal classification threshold was determined using the Youden Index. RESULTS: The final predictors included gender, mother's educational level, parental BMI, weight at age 12, parenting style, weekly sweets consumption frequency, meal duration, sleep duration, and physical fitness score. The model demonstrated robust performance, with an AUC of 0.91, accuracy of 0.86, and sensitivity of 0.84. Subgroup analysis indicated consistent performance across genders, with slightly superior predictive efficacy in males (AUC = 0.912) compared to females (AUC = 0.898). DISCUSSION: The proposed interpretable framework combines high predictive accuracy and sensitivity, offering a valuable tool for timely identification and intervention in high-risk adolescents. These findings underscore the potential of data-driven approaches in addressing adolescent obesity. CI - (c) 2025 Jiang and He. FAU - Jiang, Mei AU - Jiang M AD - Sports Institute of Chengdu University of Technology, Chengdu, Sichuan, China. FAU - He, Zhou AU - He Z AD - School of Mathematics, Southwest Jiaotong University, Chengdu, Sichuan, China. AD - Sichuan Province Big Data Research and Joint Application Technology Center of Student Health, Chengdu, Sichuan, China. AD - National-Local Joint Engineering Laboratory of System Credibility Automatic Verification, Chengdu, Sichuan, China. LA - eng PT - Journal Article DEP - 20251030 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC12611902 OTO - NOTNLM OT - Chinese students OT - LASSO regression OT - adolescent students obesity OT - lifestyle behaviors OT - prediction model COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/11/17 17:30 MHDA- 2025/11/17 17:31 PMCR- 2025/10/30 CRDT- 2025/11/17 06:21 PHST- 2025/08/01 00:00 [received] PHST- 2025/10/13 00:00 [accepted] PHST- 2025/11/17 17:31 [medline] PHST- 2025/11/17 17:30 [pubmed] PHST- 2025/11/17 06:21 [entrez] PHST- 2025/10/30 00:00 [pmc-release] AID - 10.3389/fspor.2025.1677707 [doi] PST - epublish SO - Front Sports Act Living. 2025 Oct 30;7:1677707. doi: 10.3389/fspor.2025.1677707. eCollection 2025. PMID- 41245309 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251117 LR - 20251120 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 16 DP - 2025 TI - Effects of physical activity dose on cognitive ability in Chinese adolescent students: parallel mediating roles of sleep quality and smartphone addiction. PG - 1680936 LID - 10.3389/fpsyg.2025.1680936 [doi] LID - 1680936 AB - INTRODUCTION: Adolescence is a critical developmental period marked by heightened vulnerability to cognitive and psychological disruptions. Although physical activity has been linked to improved mental health and cognition, the underlying behavioral mechanisms remain insufficiently explored. This study investigated the associations between physical activity and cognitive failures in adolescents, with sleep quality and smartphone addiction examined as parallel mediators. METHODS: A cross-sectional survey was conducted among 522 adolescents (Mean age = 15.52, SD = 1.28), who completed validated questionnaires assessing physical activity (IPAQ-SF), sleep quality (PSQI), smartphone addiction (SAS-SV), and cognitive failures (CFQ). RESULTS: Structural equation modeling revealed that higher physical activity levels were associated with fewer cognitive failures, both directly and indirectly through better sleep quality and lower smartphone addiction. Group comparisons further indicated that adolescents with high physical activity reported significantly better sleep, reduced smartphone dependence, and fewer cognitive lapses compared to those with moderate or low activity levels. Correlational analysis supported these associations. DISCUSSION: Moderate or low activity levels. Correlational analysis supported these associations. Although causal inferences cannot be drawn due to the study's cross-sectional design, the findings suggest that physical activity may be linked to improved cognitive functioning through modifiable behavioral factors. These results provide a foundation for future longitudinal and intervention-based research aiming to enhance adolescent cognitive health through lifestyle-based strategies. CI - Copyright (c) 2025 Li, Wang and Li. FAU - Li, Keqiang AU - Li K AD - Faculty of Sports Science, Wenzhou Medical University, Wenzhou, China. FAU - Wang, Qianjin AU - Wang Q AD - Faculty of Sports Science, Wenzhou Medical University, Wenzhou, China. FAU - Li, Jianye AU - Li J AD - Department of Physical Education, Shanxi Medical University, Jinzhong, China. LA - eng PT - Journal Article DEP - 20251031 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC12615395 OTO - NOTNLM OT - adolescents OT - cognitive failures OT - physical activity OT - sleep quality OT - smartphone addiction COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/11/17 17:29 MHDA- 2025/11/17 17:30 PMCR- 2025/10/31 CRDT- 2025/11/17 06:17 PHST- 2025/08/06 00:00 [received] PHST- 2025/09/09 00:00 [accepted] PHST- 2025/11/17 17:30 [medline] PHST- 2025/11/17 17:29 [pubmed] PHST- 2025/11/17 06:17 [entrez] PHST- 2025/10/31 00:00 [pmc-release] AID - 10.3389/fpsyg.2025.1680936 [doi] PST - epublish SO - Front Psychol. 2025 Oct 31;16:1680936. doi: 10.3389/fpsyg.2025.1680936. eCollection 2025. PMID- 41243729 OWN - NLM STAT- MEDLINE DCOM- 20251117 LR - 20260918 IS - 1365-277X (Electronic) IS - 0952-3871 (Print) IS - 0952-3871 (Linking) VI - 38 IP - 6 DP - 2025 Dec TI - Development and Validation of a New Tool for Assessing the Intake of Ultra-Processed Foods in Adult Population: GR-UPFAST. PG - e70166 LID - 10.1111/jhn.70166 [doi] LID - e70166 AB - BACKGROUND AND AIMS: One of the most widely used classification systems for ultra-processed foods is NOVA. However, it lacks adaptability to the Greek dietary context and market. Thus, the aim was to develop a valid and easy-to-use tool, friendly to health professionals, which, in combination with the existing nutritional assessment tools, will be able to determine the level of UPF consumption and dietary habits of young Greek adults. METHODS: For the GR-UPFAST (GReek Ultra Processed Food intake ASsessment Tool) design, a multi-station procedure was followed; literature review, field visits in food markets, classification, and definition of food types and portions. Four experienced nutritionists conducted content and face validity. Then, a cross-sectional study in 220 young adults, aged 18-30, both males and females was performed. Internal consistency of the GR-UPFAST was assessed using Cronbach's alpha. Criterion and predictive validity were evaluated through Spearman's correlations with MedDietScore and body weight. Construct validity was assessed with confirmatory factor analysis. RESULTS: Total Cronbach's alpha value was 0.766. Cronbach's alpha values if an item deleted ranged from 0.720 to 0.770, indicating overall good and stable internal consistency. Confirmatory factor analysis confirmed the one-dimension GR-UPFAST's structure, and the very good model fit (x(2)/df = 0.61). GR-UPFAST score was negatively correlated with the MedDietScore (rho = -0.162, p = 0.016) and positively with body weight (rho = 0.140, p = 0.039). CONCLUSIONS: GR-UPFAST appears to be a practical and valid tool for assessing UPF consumption among Greek younger adults. It may enhance comprehension of nutrition in younger adults and probably in other Greek and Mediterranean populations. CI - (c) 2025 The Author(s). Journal of Human Nutrition and Dietetics published by John Wiley & Sons Ltd on behalf of British Dietetic Association. FAU - Foscolou, Alexandra AU - Foscolou A AD - Department of Nutritional Science and Dietetics, School of Health Sciences, University of the Peloponnese, Antikalamos, Kalamata, Greece. FAU - Kousta, Evgenia AU - Kousta E AD - Department of Nutritional Science and Dietetics, School of Health Sciences, University of the Peloponnese, Antikalamos, Kalamata, Greece. FAU - Trikalioti, Katerina AU - Trikalioti K AD - Department of Nutritional Science and Dietetics, School of Health Sciences, University of the Peloponnese, Antikalamos, Kalamata, Greece. FAU - Liva, Konstantina AU - Liva K AD - Department of Nutritional Science and Dietetics, School of Health Sciences, University of the Peloponnese, Antikalamos, Kalamata, Greece. FAU - Nikolaou, Giannoula AU - Nikolaou G AD - Department of Nutritional Science and Dietetics, School of Health Sciences, University of the Peloponnese, Antikalamos, Kalamata, Greece. FAU - Panoutsopoulos, Georgios I AU - Panoutsopoulos GI AD - Department of Nutritional Science and Dietetics, School of Health Sciences, University of the Peloponnese, Antikalamos, Kalamata, Greece. FAU - Dimitriou, Maria AU - Dimitriou M AD - Department of Nutritional Science and Dietetics, School of Health Sciences, University of the Peloponnese, Antikalamos, Kalamata, Greece. FAU - Kaliora, Andriana C AU - Kaliora AC AUID- ORCID: 0000-0003-3843-7331 AD - Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece. FAU - Gioxari, Aristea AU - Gioxari A AUID- ORCID: 0000-0002-4869-6815 AD - Department of Nutritional Science and Dietetics, School of Health Sciences, University of the Peloponnese, Antikalamos, Kalamata, Greece. LA - eng GR - The authors received no specific funding for this work./ PT - Journal Article PT - Validation Study PL - England TA - J Hum Nutr Diet JT - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JID - 8904840 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Cross-Sectional Studies MH - Young Adult MH - Greece MH - *Fast Foods MH - Reproducibility of Results MH - Adolescent MH - *Nutrition Assessment MH - *Diet MH - Feeding Behavior MH - *Diet Surveys/methods MH - Food, Processed PMC - PMC12621074 OTO - NOTNLM OT - GR-UPFAST OT - Greek population OT - Mediterranean diet OT - UPF OT - body weight OT - new dietary assessment tool OT - ultra-processed foods COIS- The authors declare no conflicts of interest. EDAT- 2025/11/17 09:08 MHDA- 2025/11/17 09:09 PMCR- 2025/11/17 CRDT- 2025/11/17 04:24 PHST- 2025/09/02 00:00 [revised] PHST- 2025/06/23 00:00 [received] PHST- 2025/11/01 00:00 [accepted] PHST- 2025/11/17 09:09 [medline] PHST- 2025/11/17 09:08 [pubmed] PHST- 2025/11/17 04:24 [entrez] PHST- 2025/11/17 00:00 [pmc-release] AID - JHN70166 [pii] AID - 10.1111/jhn.70166 [doi] PST - ppublish SO - J Hum Nutr Diet. 2025 Dec;38(6):e70166. doi: 10.1111/jhn.70166. PMID- 41243686 OWN - NLM STAT- MEDLINE DCOM- 20251117 LR - 20260918 IS - 1365-277X (Electronic) IS - 0952-3871 (Print) IS - 0952-3871 (Linking) VI - 38 IP - 6 DP - 2025 Dec TI - Validity of Weighed and Digital Photography Diet Estimation Study in a Childcare Setting. PG - e70160 LID - 10.1111/jhn.70160 [doi] LID - e70160 AB - INTRODUCTION: Estimating food intake in children is a critical part of obesity prevention and nutrition intervention studies. Accurate and convenient methods to measure food intake among preschool children attending early childcare centers (ECCs) are lacking and digital photography may be a convenient option but needs to be validated in the childcare setting. This pilot study assessed the validity of weighed and digital photography plate waste methods. METHODS: Weighed and digital photography plate waste methods were used to estimate food intake during lunch for three consecutive days. Pre-consumption weight of each food was measured in grams. Weighed foods were assembled on a tray and photos were taken. Post-consumption weights and photos were taken for comparison. Two trained research assistants independently estimated food consumption at 10% intervals for the digital photography method; differences in pre- and post-weights were used for weighed method. Food consumption was measured by the difference in grams or estimated percentage in pre-and post-meal weights and photos, respectively. Validity was measured using linear mixed models and Bland Altman regressions to assess differences between digital photography and weighed measurements. RESULTS: Participants were 41 children (mean age 3.86 +/- 0.51, 84% Hispanic/Latino, 58.5% females) enrolled in two Head Start centers. Linear mixed model assessment found no significant difference between macro- or micronutrients, or food groups between the two methods. Bland Altman regression revealed a high level of agreement between weighed and digital photography methods for macronutrients, micronutrients, and food groups. CONCLUSION: Weighed and digital photography plate waste methods yield similar results, and both are valid methods to assess food intake in pre-school aged children to aid in intervention studies along with evaluating menu quality. Choice of assessment methods depends on budget, time, equipment, expertise, and training. CI - (c) 2025 The Author(s). Journal of Human Nutrition and Dietetics published by John Wiley & Sons Ltd on behalf of British Dietetic Association. FAU - Ullevig, Sarah L AU - Ullevig SL AD - College for Health, Community and Policy, University of Texas at San Antonio, San Antonio, Texas, USA. FAU - Sosa, Erica T AU - Sosa ET AD - Department of Public Health, University of Texas at San Antonio, San Antonio, Texas, USA. FAU - Howard, Jeffrey T AU - Howard JT AD - Department of Public Health, University of Texas at San Antonio, San Antonio, Texas, USA. FAU - Liang, Yuanyuan AU - Liang Y AD - Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA. FAU - Doolittle, Kelsey AU - Doolittle K AD - College for Health, Community and Policy, University of Texas at San Antonio, San Antonio, Texas, USA. FAU - Parra-Medina, Deborah AU - Parra-Medina D AD - Center for Health Equity, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FAU - Yin, Zenong AU - Yin Z AD - Department of Public Health, University of Texas at San Antonio, San Antonio, Texas, USA. LA - eng GR - R01 DK109323/DK/NIDDK NIH HHS/United States GR - This study was funded by the United States National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases (R01DK109323)./ PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, P.H.S. PT - Validation Study PL - England TA - J Hum Nutr Diet JT - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JID - 8904840 SB - IM MH - Humans MH - *Photography/methods MH - Child, Preschool MH - Pilot Projects MH - *Child Day Care Centers MH - Female MH - Male MH - Reproducibility of Results MH - *Diet MH - Energy Intake MH - Lunch MH - *Diet Surveys/methods MH - Nutrition Assessment PMC - PMC12620928 OTO - NOTNLM OT - childcare OT - diet assessment OT - photography OT - plate waste OT - preschool children COIS- The authors declare no conflicts of interest. EDAT- 2025/11/17 09:08 MHDA- 2025/11/17 09:09 PMCR- 2025/11/17 CRDT- 2025/11/17 04:13 PHST- 2025/10/22 00:00 [revised] PHST- 2025/03/28 00:00 [received] PHST- 2025/10/31 00:00 [accepted] PHST- 2025/11/17 09:09 [medline] PHST- 2025/11/17 09:08 [pubmed] PHST- 2025/11/17 04:13 [entrez] PHST- 2025/11/17 00:00 [pmc-release] AID - JHN70160 [pii] AID - 10.1111/jhn.70160 [doi] PST - ppublish SO - J Hum Nutr Diet. 2025 Dec;38(6):e70160. doi: 10.1111/jhn.70160. PMID- 41243430 OWN - NLM STAT- MEDLINE DCOM- 20251222 LR - 20251222 IS - 2993-7175 (Electronic) IS - 2993-7175 (Linking) VI - 49 IP - 12 DP - 2025 Dec TI - Renal and cardiovascular function in children with FASD: Potential links to food approach and avoidance behaviors. PG - 2695-2706 LID - 10.1111/acer.70200 [doi] AB - BACKGROUND: Fetal alcohol spectrum disorder (FASD) is associated with a range of developmental, behavioral, and physical impairments. While much research to date has focused on developmental and behavioral aspects of FASD, there is growing evidence that children with FASD may experience alterations in renal and cardiovascular function. By also comparing eating behaviors between children with FASD and typically developing children, this may provide some clues to the underlying causes of these physiological changes. METHODS: In this study, we recruited children and adolescents with (n = 34) and without (n = 22) a diagnosis of FASD. We measured several cardiovascular and renal outcomes and analyzed potential associations with eating behaviors related to food approach and avoidance, assessed from caregiver report using the Children's Eating Behavior Questionnaire (CEBQ). RESULTS: Children with FASD had significantly elevated urinary sodium-to-potassium (Na(+)/K(+)) ratio, a trend for increasing urine sodium (Na(+)), and a reduction in the normal age-associated rise in urine creatinine compared to typically developing controls. The FASD group also exhibited significantly elevated resting heart rate. Additionally, those with a diagnosis of FASD had higher scores for subscales of food approach (food responsiveness, emotional overeating, desire to drink) and a trend toward a higher food avoidance score on the CEBQ. A subset of these behavioral scores was associated with cardiovascular but not renal outcomes. CONCLUSIONS: Together, these findings suggest that renal and cardiovascular function may be altered in children and adolescents with FASD, which may be linked to abnormal food-related behaviors and/or other clinical or demographic factors. While the mechanisms underlying these early-life physiological changes are not fully understood, it is likely they contribute to poorer long-term health outcomes. Further research is needed to validate these preliminary findings in larger cohorts, explore the underlying mechanisms and investigate potential long-term implications of these findings. CI - (c) 2025 Research Society on Alcohol. FAU - Reid, Natasha AU - Reid N AUID- ORCID: 0000-0001-9813-5613 AD - Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia. FAU - Logan, Jayden AU - Logan J AUID- ORCID: 0009-0003-7279-4751 AD - Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia. FAU - Garavelis, Khari AU - Garavelis K AD - Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia. FAU - Yang, Jinyang AU - Yang J AD - Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia. FAU - Hayes, Nicole AU - Hayes N AD - School of Education, Queensland University of Technology, Brisbane, Queensland, Australia. FAU - Vanderpeet, Chelsea AU - Vanderpeet C AD - Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia. FAU - Liddle, Karen AU - Liddle K AD - Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia. AD - Children's Health Queensland, Brisbane, Queensland, Australia. FAU - Young, Sophia AU - Young S AD - Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia. FAU - Maloney, Maree AU - Maloney M AD - School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Queensland, Australia. FAU - Sullivan, Emily AU - Sullivan E AD - Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia. FAU - Moritz, Karen AU - Moritz K AD - School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland, Australia. FAU - Akison, Lisa AU - Akison L AUID- ORCID: 0000-0002-2667-3743 AD - School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland, Australia. LA - eng PT - Journal Article DEP - 20251116 PL - United States TA - Alcohol Clin Exp Res (Hoboken) JT - Alcohol, clinical & experimental research JID - 9918609780906676 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - Adolescent MH - *Feeding Behavior/physiology/psychology MH - *Kidney/physiopathology MH - *Fetal Alcohol Spectrum Disorders/physiopathology/psychology/urine MH - *Avoidance Learning/physiology MH - Heart Rate/physiology OTO - NOTNLM OT - cardiovascular OT - electrolytes OT - fetal alcohol spectrum disorder OT - food approach OT - renal EDAT- 2025/11/17 09:08 MHDA- 2025/12/22 19:42 CRDT- 2025/11/17 02:06 PHST- 2024/12/02 00:00 [received] PHST- 2025/10/21 00:00 [accepted] PHST- 2025/12/22 19:42 [medline] PHST- 2025/11/17 09:08 [pubmed] PHST- 2025/11/17 02:06 [entrez] AID - 10.1111/acer.70200 [doi] PST - ppublish SO - Alcohol Clin Exp Res (Hoboken). 2025 Dec;49(12):2695-2706. doi: 10.1111/acer.70200. Epub 2025 Nov 16. PMID- 41241953 OWN - NLM STAT- MEDLINE DCOM- 20260624 LR - 20260624 IS - 1465-3966 (Electronic) IS - 1354-8506 (Linking) VI - 31 IP - 6 DP - 2026 Jul TI - Does social media addiction and its effects on eating behavior depend on perceived stress? PG - 1497-1512 LID - 10.1080/13548506.2025.2587254 [doi] AB - Social media has become an integral part of our lives. However, social media addiction can have effects on mental health and eating behaviors. The present study aims to examine the associations among perceived stress, body image perception, social media-related eating behaviors, and social media addiction, and to identify the extent to which these factors, along with body mass index (BMI) and age, predict social media addiction among adults. The study was designed as a cross-sectional analytical study. Five hundred ninety-eight adults aged 18 to 64 (mean age 27.1 +/- 9.81 years) participated in the study; the sample comprised 69.4% females and 30.6% males. The study was conducted with adults residing in Turkiye. Data were collected via a face-to-face questionnaire. The questionnaire consisted of validated instruments assessing social media addiction, the impact of social media on eating behavior, body image perception, and stress perception. The results showed that while social media addiction did not differ by gender, female participants reported higher levels of perceived stress and social media-related eating behavior scores. Perceived stress was positively associated with both social media addiction and social media-related eating behavior. Furthermore, stress and social media-related eating behaviors predict addiction across body image perception groups according to multiple regression analysis. In conclusion, there are significant gender variations in stress and eating habits, and perceived stress is a major predictor of social media addiction. To lessen social media addiction and its effects on eating habits, our findings emphasize the significance of stress management and focused interventions. FAU - AtabIlen Pinar, Busra AU - AtabIlen Pinar B AUID- ORCID: 0000-0002-8485-1763 AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Karamanoglu Mehmetbey University, Karaman, Turkiye. FAU - Arslan, Neslihan AU - Arslan N AD - Gulhane Faculty of Health Sciences, Department of Nutrition and Dietetics, Health Sciences University, Ankara, Turkiye. FAU - EsIn, Kubra AU - EsIn K AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Tokat Gaziosmanpasa University, Tokat, Turkiye. FAU - YassibaS, Emine AU - YassibaS E AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Gazi University, Ankara, Turkiye. FAU - Ayyildiz, Feride AU - Ayyildiz F AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Gazi University, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20251116 PL - England TA - Psychol Health Med JT - Psychology, health & medicine JID - 9604099 SB - IM MH - Humans MH - Female MH - Male MH - Adult MH - *Social Media MH - Cross-Sectional Studies MH - Subjective Stress MH - *Feeding Behavior/psychology MH - Young Adult MH - *Body Image/psychology MH - Adolescent MH - Middle Aged MH - *Stress, Psychological/psychology MH - Surveys and Questionnaires MH - *Behavior, Addictive/psychology MH - Sex Factors MH - Body Mass Index MH - Media Exposure MH - Digital Media OAB - The impact of social media on eating behavior is more pronounced in female participants.Stress-related helplessness may increase social media use as a coping strategy.Overcoming social media addiction requires effective stress management, and personalized interventions are necessary to achieve this. OABL- eng OTO - NOTNLM OT - Social media OT - body image OT - eating behavior OT - stress EDAT- 2025/11/16 18:27 MHDA- 2026/06/24 12:36 CRDT- 2025/11/16 13:52 PHST- 2026/06/24 12:36 [medline] PHST- 2025/11/16 18:27 [pubmed] PHST- 2025/11/16 13:52 [entrez] AID - 10.1080/13548506.2025.2587254 [doi] PST - ppublish SO - Psychol Health Med. 2026 Jul;31(6):1497-1512. doi: 10.1080/13548506.2025.2587254. Epub 2025 Nov 16. PMID- 41241827 OWN - NLM STAT- MEDLINE DCOM- 20260521 LR - 20260922 IS - 1941-2452 (Electronic) IS - 0884-5336 (Print) IS - 0884-5336 (Linking) VI - 41 IP - 3 DP - 2026 Jun TI - Assessing the reliability of interprofessional raters on peripheral muscle ultrasonography in pediatric oncology: A prospective observational study. PG - 928-936 LID - 10.1002/ncp.70071 [doi] AB - BACKGROUND: Skeletal muscle is critical for functional status, quality of life, and treatment tolerance in pediatric patients with cancer. Traditional assessments of muscle mass involve radiation and are often unsuitable for frequent monitoring. Ultrasound (US) is noninvasive and radiation-free; however, its reliability in pediatric patients with cancer, who experience rapid changes in body composition, is not well established. This study aimed to determine the interrater reliability of US for measuring key muscle parameters. METHODS: A novice and an expert sonographer blindly measured muscle thickness (mT), cross-sectional area (CSA), and echo intensity (EI) for the quadriceps femoris (QF) and tibialis anterior (TA) muscles in an oncology group and a healthy group. Interclass correlation coefficients were calculated to assess interrater reliability. RESULTS: A total of 27 participants were included (n = 14 oncology and n = 13 healthy). All quadriceps measures had good reliability, with QF mT = 0.895 (95% CI, 0.77-0.952), rectus femoris (RF) mT = 0.881 (95% CI, 0.74-0.946), CSA = 0.801 (95% CI, 0.563-0.909), and EI = 0.839 (95% CI, 0.647-0.927). All TA measures had excellent reliability: mT = 0.968 (95% CI, 0.929-0.985), CSA = 0.925 (95% CI, 0.835-0.966), and EI = 0.909 (95% CI, 0.801-0.959). The oncology group's reliability remained high. Key results included RF mT = 0.906 (95% CI, 0.706-0.970), QF mT = 0.887 (95% CI, 0.646-0.964), TA mT = 0.972 (95% CI, 0.912-0.991), CSA = 0.947 (95% CI, 0.836-0.983), and EI = 0.943 (95% CI, 0.822-0.982). CONCLUSION: Point-of-care US is a reliable method to measure muscle in pediatric oncology patients. Moreover, novice sonographers can be trained to perform these measurements reliably. CI - (c) 2025 American Society for Parenteral and Enteral Nutrition. FAU - Hawes, Corey AU - Hawes C AUID- ORCID: 0000-0002-3444-0923 AD - Department of Pediatrics, University of Kentucky, Lexington, Kentucky, USA. FAU - Gonzalez-Seguel, Felipe AU - Gonzalez-Seguel F AUID- ORCID: 0000-0001-9099-2389 AD - Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, Kentucky, USA. FAU - Horikawa-Strakovsky, Arimitsu AU - Horikawa-Strakovsky A AUID- ORCID: 0009-0005-7334-946X AD - Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, Kentucky, USA. AD - Division of Biomedical Informatics, Department of Internal Medicine, University of Kentucky, Lexington, Kentucky, USA. FAU - Wen, Yuan AU - Wen Y AD - Division of Biomedical Informatics, Department of Internal Medicine, University of Kentucky, Lexington, Kentucky, USA. AD - Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, USA. FAU - Munnikhuysen, Senna AU - Munnikhuysen S AD - Department of Pediatrics, University of Kentucky, Lexington, Kentucky, USA. FAU - Mayer, Kirby P AU - Mayer KP AUID- ORCID: 0000-0003-3844-3846 AD - Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, Kentucky, USA. LA - eng GR - K23 AR079583/AR/NIAMS NIH HHS/United States GR - UL1 TR001998/TR/NCATS NIH HHS/United States GR - The project was supported by the NIH National Center for Advancing Translational Sciences through grant no. UL1TR001998. Kirby P. Mayer was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health (grant no. K23- AR079583)./ PT - Journal Article PT - Observational Study DEP - 20251116 PL - United States TA - Nutr Clin Pract JT - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JID - 8606733 SB - IM MH - Humans MH - Ultrasonography/methods MH - Reproducibility of Results MH - Child MH - Male MH - Female MH - Prospective Studies MH - *Neoplasms/complications MH - *Muscle, Skeletal/diagnostic imaging MH - Adolescent MH - Quadriceps Muscle/diagnostic imaging MH - Observer Variation MH - Body Composition MH - Child, Preschool PMC - PMC13180273 MID - NIHMS2175093 OTO - NOTNLM OT - muscle ultrasound OT - pediatric oncology OT - reliability OT - validity COIS- CONFLICT OF INTEREST STATEMENT Yuan Wen is the founder of MyoAnalytics LLC. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. EDAT- 2025/11/16 13:21 MHDA- 2026/05/21 12:35 PMCR- 2026/05/18 CRDT- 2025/11/16 07:22 PHST- 2025/10/22 00:00 [revised] PHST- 2025/07/09 00:00 [received] PHST- 2025/10/23 00:00 [accepted] PHST- 2026/05/21 12:35 [medline] PHST- 2025/11/16 13:21 [pubmed] PHST- 2025/11/16 07:22 [entrez] PHST- 2026/05/18 00:00 [pmc-release] AID - 10.1002/ncp.70071 [doi] PST - ppublish SO - Nutr Clin Pract. 2026 Jun;41(3):928-936. doi: 10.1002/ncp.70071. Epub 2025 Nov 16. PMID- 41239907 OWN - NLM STAT- MEDLINE DCOM- 20260309 LR - 20260309 IS - 1552-4604 (Electronic) IS - 0091-2700 (Linking) VI - 66 IP - 3 DP - 2026 Mar TI - A Phase 1 Study to Assess the Effect of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Dordaviprone. PG - e70129 LID - 10.1002/jcph.70129 [doi] AB - Dordaviprone (ONC201) is a small molecule protease activator being developed for gliomas. The aim of this work was to evaluate the pharmacokinetics and safety of dordaviprone when administered to participants with moderate hepatic impairment compared to healthy matched participants. A non-randomized, open-label, single-dose study was conducted in eight participants with moderate hepatic impairment classified according to Child-Pugh criteria, and eight healthy participants matched based on age (+10 years), body mass index (BMI; +20%), and sex. Plasma concentrations of dordaviprone and the major inactive metabolite, ONC207, were determined by a validated liquid chromatography-tandem mass spectrometry method. Exposure following oral administration of 125 mg dordaviprone was increased in participants with moderate hepatic impairment relative to healthy matched participants, with the largest impact occurring on AUC. Ratios of geometric means and 90% confidence intervals (CIs) of dordaviprone exposure for C(max), AUC(last), and AUC(inf) in the moderate hepatic impairment cohort compared to the healthy matched cohort were 1.21 (0.88, 1.67), 1.50 (1.02, 2.20), and 1.55 (1.05, 2.29), respectively. Treatment-emergent adverse events were mild in nature and considered not related to dordaviprone administration. While administration of dordaviprone in participants with moderate hepatic impairment led to increased dordaviprone exposures, the anticipated increase after the recommended 625 mg dose is within exposures assessed in the thorough QT study. Therefore, no dose adjustment in patients with mild or moderate hepatic impairment is recommended. CI - (c) 2025 American College of Clinical Pharmacology. FAU - Faison, Shamia L AU - Faison SL AD - Certara Strategic Consulting, Durham, NC, USA. FAU - Batonga, Joelle AU - Batonga J AD - Certara Strategic Consulting, Durham, NC, USA. FAU - Arumugham, Thangam AU - Arumugham T AD - Chimerix Consultant, Durham, NC, USA. FAU - Bartkus, Angela AU - Bartkus A AD - Chimerix, Inc., Durham, NC, USA. FAU - Morrison, Marion E AU - Morrison ME AD - Chimerix, Inc., Durham, NC, USA. FAU - Mullin, Mark J AU - Mullin MJ AD - Chimerix, Inc., Durham, NC, USA. FAU - Tippin, Timothy AU - Tippin T AD - Chimerix, Inc., Durham, NC, USA. FAU - Naderer, Odin AU - Naderer O AD - Chimerix, Inc., Durham, NC, USA. LA - eng GR - Chimerix, Inc., a subsidiary of Jazz Pharmaceuticals/ PT - Clinical Trial, Phase I PT - Journal Article DEP - 20251115 PL - England TA - J Clin Pharmacol JT - Journal of clinical pharmacology JID - 0366372 SB - IM MH - Humans MH - Male MH - Female MH - Middle Aged MH - Adult MH - *Liver Diseases/metabolism MH - Area Under Curve MH - Aged MH - Administration, Oral OTO - NOTNLM OT - ONC201 OT - dordaviprone OT - hepatic impairment OT - pharmacokinetics OT - phase 1 EDAT- 2025/11/15 12:32 MHDA- 2026/03/09 07:42 CRDT- 2025/11/15 06:24 PHST- 2025/10/24 00:00 [revised] PHST- 2025/08/07 00:00 [received] PHST- 2025/10/30 00:00 [accepted] PHST- 2026/03/09 07:42 [medline] PHST- 2025/11/15 12:32 [pubmed] PHST- 2025/11/15 06:24 [entrez] AID - 10.1002/jcph.70129 [doi] PST - ppublish SO - J Clin Pharmacol. 2026 Mar;66(3):e70129. doi: 10.1002/jcph.70129. Epub 2025 Nov 15. PMID- 41239812 OWN - NLM STAT- MEDLINE DCOM- 20251212 LR - 20251214 IS - 1464-5491 (Electronic) IS - 0742-3071 (Print) IS - 0742-3071 (Linking) VI - 43 IP - 1 DP - 2026 Jan TI - Psychometric properties and factor structure of the Diabetes Eating Problem Survey Revised in Danish adolescents with type 1 diabetes. PG - e70158 LID - 10.1111/dme.70158 [doi] LID - e70158 AB - AIM: The aim of this study was to examine the psychometric properties and factor structure of the Danish translation of Diabetes Eating Problem Survey - Revised (DEPS-R) among adolescents with type 1 diabetes (T1D). METHODS: A total of 131 adolescents (53% women) with T1D aged 11-19 years completed DEPS-R and Youth Eating Disorder Examination Questionnaire (YEDE-Q). Additional anthropometric, biochemical, and medical data were obtained from medical records. Exploratory Factor Analysis was performed to examine the factor structure of DEPS-R. RESULTS: The DEPS-R demonstrated good internal consistency (Cronbach alpha = 0.87) and was significantly correlated with YEDE-Q (r = 0.83; p < 0.01), HbA1c (r = 0.35; p < 0.01), zBMI (r = 0.35; p < 0.01), and age (r = 0.20; p < 0.05), indicating high convergent validity. The median DEPS-R score was 10 [5-18] for the entire sample; however, it was significantly higher among women (15 [9-21]) than men (6 [4-10]). Factor analysis revealed a three-factor structure accounting for 58% of the variance and indicated that item 4 contributed less strongly to the overall score. CONCLUSIONS: This study supports the validity of DEPS-R as a screening tool for detecting the risk of disordered eating in adolescents with T1D but challenges the relevance of item 4. Future research is needed on updating the original DEPS-R, including a sensitivity analysis of DEPS-R in detecting the risk of serious eating disorder-related behaviour in T1D. CI - (c) 2025 The Author(s). Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK. FAU - Abild, Caroline Bruun AU - Abild CB AUID- ORCID: 0000-0003-4725-9880 AD - Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark. AD - Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. AD - Department of Child and Adolescent Psychiatry- Research Unit, Aarhus University Hospital Psychiatry, Aarhus, Denmark. AD - Danish National Center for Obesity, Aarhus University Hospital, Aarhus, Denmark. FAU - Vestergaard, Esben Thyssen AU - Vestergaard ET AUID- ORCID: 0000-0003-4263-1815 AD - Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark. AD - Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. AD - Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark. FAU - Pauls, Dorthe Dalstrup AU - Pauls DD AUID- ORCID: 0000-0002-8579-3198 AD - Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark. AD - Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. AD - Danish National Center for Obesity, Aarhus University Hospital, Aarhus, Denmark. FAU - Bruun, Jens Meldgaard AU - Bruun JM AUID- ORCID: 0000-0001-9937-5467 AD - Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark. AD - Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. AD - Danish National Center for Obesity, Aarhus University Hospital, Aarhus, Denmark. FAU - Kristensen, Kurt AU - Kristensen K AUID- ORCID: 0000-0002-3912-8234 AD - Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark. AD - Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. FAU - Stoving, Rene Klinkby AU - Stoving RK AUID- ORCID: 0000-0002-4255-5544 AD - Center for Eating Disorders, Odense University Hospital, Odense, Denmark. AD - Research Unit for Medical Endocrinology, Odense University Hospital, Odense, Denmark. AD - Mental Health Services in the Region of Southern Denmark, Odense University Hospital, Odense, Denmark. FAU - Clausen, Loa AU - Clausen L AUID- ORCID: 0000-0002-4559-8347 AD - Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. AD - Department of Child and Adolescent Psychiatry- Research Unit, Aarhus University Hospital Psychiatry, Aarhus, Denmark. LA - eng GR - NNF17SA0031406/Novo Nordisk Foundation/ GR - Steno Diabetes Centre Aarhus and Danish National Centre for Obesity/ PT - Journal Article DEP - 20251115 PL - England TA - Diabet Med JT - Diabetic medicine : a journal of the British Diabetic Association JID - 8500858 SB - IM MH - Humans MH - Adolescent MH - *Diabetes Mellitus, Type 1/psychology/complications MH - Female MH - Male MH - Psychometrics MH - Denmark/epidemiology MH - *Feeding and Eating Disorders/diagnosis/psychology/epidemiology/complications MH - Child MH - Young Adult MH - Surveys and Questionnaires MH - Factor Analysis, Statistical MH - Reproducibility of Results MH - Feeding Behavior/psychology PMC - PMC12700511 OTO - NOTNLM OT - adolescence OT - disordered eating OT - eating disorder OT - screening tool OT - type 1 diabetes COIS- The authors have no relevant financial interests to disclose. EDAT- 2025/11/15 06:29 MHDA- 2025/12/12 19:28 PMCR- 2025/12/12 CRDT- 2025/11/15 03:12 PHST- 2025/09/04 00:00 [revised] PHST- 2025/06/12 00:00 [received] PHST- 2025/09/16 00:00 [accepted] PHST- 2025/12/12 19:28 [medline] PHST- 2025/11/15 06:29 [pubmed] PHST- 2025/11/15 03:12 [entrez] PHST- 2025/12/12 00:00 [pmc-release] AID - DME70158 [pii] AID - 10.1111/dme.70158 [doi] PST - ppublish SO - Diabet Med. 2026 Jan;43(1):e70158. doi: 10.1111/dme.70158. Epub 2025 Nov 15. PMID- 41239521 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251115 LR - 20251117 IS - 2055-0928 (Electronic) IS - 2055-0928 (Linking) VI - 11 IP - 1 DP - 2025 Nov 14 TI - Effects of dietary management for medium-chain acyl-CoA dehydrogenase deficiency (MCADD) on eating behaviour in childhood, adolescence and young adulthood. PG - 213 LID - 10.1186/s40795-025-01209-9 [doi] LID - 213 AB - BACKGROUND: Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) is an autosomal recessive disorder of ss-oxidation. A loss of enzyme function results in impaired breakdown of medium-chain fatty acids. The main treatment involves a dietetic approach to ensure adequate food intake and avoiding fasting. Diseases treated with a strict diet during childhood are often associated with eating problems. However, research in this area is very limited. This exploratory observational study aimed to examine the effects of dietary management and the underlying recommendations for MCADD on eating behaviour, as well as their subsequent impact on family life. METHODS: Paediatric and young adult patients (age 8-25) with MCADD and their caregivers at the University Hospital Muenster were included. A descriptive semi-quantitative study design incorporating qualitative elements was chosen. A novel combination of questions from validated questionnaires on eating behaviour was used to collect quantitative and qualitative data. Data were collected via a combination of telephone interviews and online surveys. RESULTS: Of the 28 patients contacted, 13 (46%) were successfully recruited into the study. The results showed that most of the study participants did not exhibit abnormal eating behaviour. Additionally, the patients did not show an increased prevalence of being overweight at the time of data collection. A higher temporary tendency to be overweight was only observed when considering the overall weight trend. Dietary interventions placed a higher burden on family life in infancy (0-4 years) than at the time of the survey. Maintaining a safe fasting interval was the main reason for restrictions in family life. CONCLUSION: This observational and exploratory sample showed no tendency towards abnormal eating behaviour associated with dietary management in MCADD. CI - (c) 2025. The Author(s). FAU - Banaszak, Pauline AU - Banaszak P AD - Center for Nutrition and Therapy (NuT), University of Applied Sciences Muenster, Corrensstrasse 25, Muenster, 48149, Germany. FAU - Wolke, Nadja AU - Wolke N AD - Center for Nutrition and Therapy (NuT), University of Applied Sciences Muenster, Corrensstrasse 25, Muenster, 48149, Germany. FAU - Markant, Anja AU - Markant A AD - Center for Nutrition and Therapy (NuT), University of Applied Sciences Muenster, Corrensstrasse 25, Muenster, 48149, Germany. FAU - Och, Ulrike AU - Och U AD - Department of Paediatrics, University Hospital Muenster, Albert-Schweitzer-Campus 1, Muenster, 48149, Germany. FAU - Rutsch, Frank AU - Rutsch F AD - Department of Paediatrics, University Hospital Muenster, Albert-Schweitzer-Campus 1, Muenster, 48149, Germany. FAU - Fischer, Tobias AU - Fischer T AD - Center for Nutrition and Therapy (NuT), University of Applied Sciences Muenster, Corrensstrasse 25, Muenster, 48149, Germany. tobias.fischer@fh-muenster.de. LA - eng PT - Journal Article DEP - 20251114 PL - England TA - BMC Nutr JT - BMC nutrition JID - 101672434 PMC - PMC12619415 OTO - NOTNLM OT - Dietetic restrictions OT - Dietetics OT - Eating behaviour OT - Eating disorders OT - Eating problems OT - Inborn errors of metabolism OT - Inherited errors of metabolism OT - Medium chain acyl-CoA dehydrogenase (MCAD) OT - Medium chain acyl-CoA dehydrogenase deficiency (MCADD) COIS- Declarations. Ethics approval and consent to participate: The study protocol was approved by the Ethics Committee of the Medical Association of Westphalia-Lippe and the University of Muenster (project identification code: 2023-392-f-S) in accordance with the Declaration of Helsinki. Written consent was obtained from both the participants and their legal guardians. Both verbally and in writing, children and adolescents were given age-appropriate information about the research project in simple language. Consent for publication: Not applicable to this study. Competing interests: The authors declare no competing interests. EDAT- 2025/11/15 00:29 MHDA- 2025/11/15 00:30 PMCR- 2025/11/14 CRDT- 2025/11/14 23:57 PHST- 2025/05/30 00:00 [received] PHST- 2025/11/03 00:00 [accepted] PHST- 2025/11/15 00:30 [medline] PHST- 2025/11/15 00:29 [pubmed] PHST- 2025/11/14 23:57 [entrez] PHST- 2025/11/14 00:00 [pmc-release] AID - 10.1186/s40795-025-01209-9 [pii] AID - 1209 [pii] AID - 10.1186/s40795-025-01209-9 [doi] PST - epublish SO - BMC Nutr. 2025 Nov 14;11(1):213. doi: 10.1186/s40795-025-01209-9. PMID- 41239320 OWN - NLM STAT- MEDLINE DCOM- 20251115 LR - 20251117 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Nov 14 TI - The association between weight control behaviors and health literacy among adolescents: a cross-sectional study. PG - 3956 LID - 10.1186/s12889-025-25266-8 [doi] LID - 3956 AB - BACKGROUND: The global rise in adolescent obesity underscores the need for effective weight control behaviors (WCBs) as an integral part of adolescents' lifestyles. Health literacy (HL), widely recognized as a key determinant of health outcomes, is an important factor in supporting informed health decisions. Given the potential influence of HL on health behaviors, this study aims to examine the association between WCBs and HL among adolescents in Tehran, Iran. METHODS: A cross-sectional study was conducted from September to November 2021 across ten health service centers in southern Tehran. Adolescents were recruited via multistage random sampling. Data were collected using validated self-administered questionnaires assessing demographics, WCBs (healthy, unhealthy, and very unhealthy), and HL using the Health Literacy in School-Age Children scale. Descriptive statistics summarized participant characteristics and behaviors. A generalized linear model was used to adjust for age and BMI. In all tests, p < 0.05 was considered statistically significant. RESULTS: Among the 240 adolescents included (mean age 14.25 +/- 1.29 years; 48.8% female), 73.8% had a normal BMI, 7.1% were underweight, and 19.1% were overweight/obese. Nearly all (97.1%) reported at least one healthy WCB; 65.5% reported at least one unhealthy, and fewer than 5% reported very unhealthy behaviors. The mean HL score was 34.23 +/- 4.48. Higher HL was associated with healthy WCBs, with odds increasing 3.4-fold from low to high HL (p < 0.001). No significant associations were detected between HL and unhealthy or very unhealthy WCBs. CONCLUSIONS: These findings underscore the relevance of HL in promoting healthy WCBs among adolescents. The study highlights the potential value of developing strategies and programs to enhance HL, particularly for adolescents with higher BMI or those at risk of unhealthy behaviors, to support healthier lifestyle choices. Future longitudinal research is needed to further clarify the relationship between HL and WCBs over time. CI - (c) 2025. The Author(s). FAU - Heydari, Maryam AU - Heydari M AUID- ORCID: 0009-0002-9177-5698 AD - Department of Community Health and Geriatric Nursing, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran. AD - Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran. FAU - Pashaeypoor, Shahzad AU - Pashaeypoor S AUID- ORCID: 0000-0002-2012-3783 AD - Community Based Participatory Research Center, Tehran University of Medical Sciences, Tehran, Iran. FAU - Negarandeh, Reza AU - Negarandeh R AUID- ORCID: 0000-0002-7597-5094 AD - Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran. rnegarandeh@tums.ac.ir. LA - eng PT - Journal Article DEP - 20251114 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Adolescent MH - Female MH - Male MH - *Health Literacy/statistics & numerical data MH - Iran/epidemiology MH - *Pediatric Obesity/prevention & control MH - *Health Behavior MH - Surveys and Questionnaires MH - *Adolescent Behavior/psychology PMC - PMC12619164 OTO - NOTNLM OT - Adolescents OT - Cross-sectional study OT - Health literacy OT - Iran OT - Weight loss COIS- Declarations. Ethics approval and consent to participate: Ethical approval for this study was granted by the Ethics Committee of the Faculty of Medicine at Tehran University of Medical Sciences (Approval Code: IR.TUMS.MEDICINE.REC.1400.222). Prior to participation, all individuals received detailed information about the study's objectives and procedures to support informed decision-making. Participant confidentiality was strictly upheld: personal data were anonymized, securely stored, and accessible only to authorized research personnel. Verbal assent was obtained from adolescent participants, and written informed consent was obtained from their parents in accordance with the Declaration of Helsinki [46], as all participants were under the age of 18. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/15 00:29 MHDA- 2025/11/15 06:30 PMCR- 2025/11/14 CRDT- 2025/11/14 23:50 PHST- 2025/08/25 00:00 [received] PHST- 2025/10/13 00:00 [accepted] PHST- 2025/11/15 06:30 [medline] PHST- 2025/11/15 00:29 [pubmed] PHST- 2025/11/14 23:50 [entrez] PHST- 2025/11/14 00:00 [pmc-release] AID - 10.1186/s12889-025-25266-8 [pii] AID - 25266 [pii] AID - 10.1186/s12889-025-25266-8 [doi] PST - epublish SO - BMC Public Health. 2025 Nov 14;25(1):3956. doi: 10.1186/s12889-025-25266-8. PMID- 41238104 OWN - NLM STAT- MEDLINE DCOM- 20260402 LR - 20260901 IS - 1876-4738 (Electronic) IS - 0914-5087 (Linking) VI - 87 IP - 4 DP - 2026 Apr TI - Defining ascending aorta dilatation in pediatric bicuspid aortic valve: Comparison of known classical and new z-score nomograms, and anthropometric parameters indexing for its assessment. PG - 375-382 LID - S0914-5087(25)00277-1 [pii] LID - 10.1016/j.jjcc.2025.11.001 [doi] AB - BACKGROUND: Ascending aorta (AscAo) dilatation assessment and definition in pediatric bicuspid aortic valve (BAV) is challenging. We compared the Pediatric Heart Network (PHN) nomogram against the Halifax (HZ) one and analyzed their association with body surface area indexing (BSAI). METHODS: Echocardiographies from a national BAV registry were analyzed. AscAo and sinus of Valsalva, standardized using nomograms and BSAI, were compared by correlation and Bland-Altman tests. Nomogram +2 and + 3 z-scores thresholds contrasted against >21 mm/BSA-m2 by logistic regression and kappa agreement index. Age subgroup analysis was between adult-size (>/=10 years and BSA >/=1.5 m(2)) and small children. RESULTS: A total 3858 reports were analyzed. The PHN nomogram resulted in higher AscAo z-scores (median 1.516 versus 1.413). Nomogram correlation was Rho(Spearman) = 0.979 and Bland-Altman agreement bias was 0.302, with higher divergence in extreme z-scores. Patients >/=10 years and BSA >/=1.5 m(2) showed better concordance (bias -0.212 versus 0.440) despite similar correlation to the younger group. There was moderate but significant correlation amongst AscAo BSA-indexed diameters and PHN (Rho(Spearman) = 0.514, p < 0.001) and HZ nomograms (Rho(Spearman) = 0.366, p < 0.001), being higher in the older cohort than the younger, both by PHN (Rho(Spearmam) 0.961 versus 0.424) and HZ (Rho(Spearman) 0.952 versus 0.540). Higher area under the curve was obtained by PHN. A lower percentage was classified as dilated with PHN than by BSA-I in the adult-size cohort, but not in younger patients. DISCUSSION: There was good correlation and concordance between HZ and PHN nomograms, the latter resulting in higher z-scores. PHN has better agreement with BSA-I than HZ, with the PHN > +3 z-score threshold being the highest predictor for BSA-I dilatation definition, also showing higher specificity and sensitivity. BSA-I classified fewer patients as dilated than nomograms in adult-sized children but not in the younger cohort. Clinicians should be aware of this effect of BSA when normalizing diameters. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Freixa-Benavente, Andrea AU - Freixa-Benavente A AD - Department of Pediatrics, Obstetrics and Gynecology and Preventive Medicine and Public Health, University Autonoma de Barcelona, Bellaterra, Spain; Pediatric Cardiology Service, Vall Hebron University Hospital, Barcelona, Spain; Pediatric Cardiology Service, Royal Brompton Hospital, London, United Kingdom. Electronic address: 1609355@uab.cat. FAU - Juzga-Corrales, Carolina AU - Juzga-Corrales C AD - Pediatric Cardiology Service, Vall Hebron University Hospital, Barcelona, Spain. FAU - Ayerza-Casas, Ariadna AU - Ayerza-Casas A AD - Pediatric Cardiology Unit, Pediatric Service, Miguel Servet University Hospital, Zaragoza, Spain. FAU - Figueras-Coll, Marc AU - Figueras-Coll M AD - Department of Pediatrics, Obstetrics and Gynecology and Preventive Medicine and Public Health, University Autonoma de Barcelona, Bellaterra, Spain; Pediatric Cardiology Unit, Pediatric Service, Josep Trueta University Hospital, Girona, Spain. FAU - Escriba-Bori, Silvia AU - Escriba-Bori S AD - Pediatric Cardiology Unit, Pediatric Service, Son Espases University Hospital, Palma de Mallorca, Spain. FAU - Plata-Izquierdo, Beatriz AU - Plata-Izquierdo B AD - Pediatric Cardiology Unit, Pediatric Service, University Complejo Asistencial Salamanca, Salamanca, Spain. FAU - Collell, Rosa AU - Collell R AD - Pediatric Cardiology Unit, Pediatric Service, Sant Joan de Reus University Hospital, Reus, Spain. FAU - Gonzalez-Marin, Maria Arantzazu AU - Gonzalez-Marin MA AD - Pediatric Cardiology Unit, Pediatric Service, University General Hospital, Ciudad Real, Spain. FAU - Siurana, Jose Manuel AU - Siurana JM AD - Pediatric Cardiology and Cardiology Services, Hospital HM de Nens, HM Hospitals, Health Investigation Institute HM Hospitals, Barcelona, Spain. FAU - Sorli-Garcia, Moises AU - Sorli-Garcia M AD - Pediatric Cardiology Unit, Pediatric Service, General University Hospital Santa Lucia, Cartagena, Spain. FAU - Albert-De La Torre, Leticia AU - Albert-De La Torre L AD - Pediatric Institute of the Heart, 12 de Octubre University Hospital, Madrid, Spain. FAU - Teodoro-Marin, Silvia AU - Teodoro-Marin S AD - Pediatric Cardiology Unit, Pediatric Service, University Hospital Parc Tauli, Sabadell, Spain. FAU - Rodriguez, Monica AU - Rodriguez M AD - Congenital Cardiology and Cardiac Surgery Service, HM Monteprincipe Hospital, Madrid, Spain. FAU - Dominguez-Garcia, Olga AU - Dominguez-Garcia O AD - Pediatric Cardiology Unit, Pediatric Service, Virgen de la Salud Hospital, Toledo, Spain. FAU - Rellan, Sara AU - Rellan S AD - Pediatric Cardiology Unit, Pediatric Service, Valladolid Clinic University Hospital, Valladolid, Spain. FAU - Manso, Begona AU - Manso B AD - Pediatric Cardiology Unit, Pediatric Service, Virgen del Rocio University Hospital, Sevilla, Spain. FAU - Lopez-Abel, Bernardo AU - Lopez-Abel B AD - Pediatric Cardiology Unit, Pediatric Service, University Hospital Santiago de Compostela, Santiago de Compostela, Spain. FAU - Alvarez-Perez, Roser AU - Alvarez-Perez R AD - Pediatric Cardiology Unit, Pediatric Service, Santa Creu I Sant Pau Hospital, Barcelona, Spain. FAU - Portillo-Marquez, Manuel AU - Portillo-Marquez M AD - Pediatric Cardiology Unit, Pediatric Service, Merida Hospital, Badajoz, Spain. FAU - Rezola-Arcelus, Erika AU - Rezola-Arcelus E AD - Pediatric Cardiology Unit, Pediatric Service, Donostia University Hospital, Donostia, Spain. FAU - Centeno-Malfaz, Fernando AU - Centeno-Malfaz F AD - Pediatric Cardiology Unit, Pediatric Service, Rio Ortega University Hospital, Valladolid, Spain. FAU - Solana-Gracia, Ruth AU - Solana-Gracia R AD - Pediatric Cardiology Unit, Pediatric Service, Infanta Leonor University Hospital, Madrid, Spain. FAU - Rojo-Sombrero, Henar AU - Rojo-Sombrero H AD - Pediatric Cardiology Unit, Pediatric Service, Principe de Asturias University Hospital, Alcala de Henares, Spain. FAU - Cantero-Tejedor, Maria-Teresa AU - Cantero-Tejedor MT AD - Pediatric Cardiology Unit, Pediatric Service, Complejo Asistencial Palencia, Palencia, Spain. FAU - Riano, Bibiana AU - Riano B AD - Pediatric Cardiology Unit, Cardiology Service, San Pedro Hospital, Logrono, Spain. FAU - Tejero-Hernandez, Maria Angeles AU - Tejero-Hernandez MA AD - Clinical Management Unit, Regional University Hospital Reina Sofia, Cordoba, Spain. FAU - Jimenez-Casso, Marisol AU - Jimenez-Casso M AD - Pediatric Cardiology Unit, Pediatric Service, General Hospital Segovia, Segovia, Spain. FAU - Sabate-Rotes, Anna AU - Sabate-Rotes A AD - Department of Pediatrics, Obstetrics and Gynecology and Preventive Medicine and Public Health, University Autonoma de Barcelona, Bellaterra, Spain; Pediatric Cardiology Service, Vall Hebron University Hospital, Barcelona, Spain. LA - eng PT - Comparative Study PT - Journal Article DEP - 20251112 PL - Netherlands TA - J Cardiol JT - Journal of cardiology JID - 8804703 SB - IM MH - Humans MH - *Nomograms MH - Child MH - Male MH - Female MH - *Aorta/diagnostic imaging/pathology MH - Bicuspid Aortic Valve Disease MH - *Aortic Valve/abnormalities/diagnostic imaging MH - Adolescent MH - Body Surface Area MH - *Heart Valve Diseases/diagnostic imaging MH - Echocardiography MH - Child, Preschool MH - Dilatation, Pathologic MH - Anthropometry MH - Infant MH - Registries OTO - NOTNLM OT - Ascending aorta dilatation OT - Bicuspid aortic valve OT - Body surface area OT - Nomograms OT - Pediatrics COIS- Declaration of competing interest The authors declare no conflicts of interest. EDAT- 2025/11/15 00:29 MHDA- 2026/04/03 00:31 CRDT- 2025/11/14 19:17 PHST- 2025/06/15 00:00 [received] PHST- 2025/11/01 00:00 [revised] PHST- 2025/11/07 00:00 [accepted] PHST- 2026/04/03 00:31 [medline] PHST- 2025/11/15 00:29 [pubmed] PHST- 2025/11/14 19:17 [entrez] AID - S0914-5087(25)00277-1 [pii] AID - 10.1016/j.jjcc.2025.11.001 [doi] PST - ppublish SO - J Cardiol. 2026 Apr;87(4):375-382. doi: 10.1016/j.jjcc.2025.11.001. Epub 2025 Nov 12. PMID- 41237332 OWN - NLM STAT- MEDLINE DCOM- 20251114 LR - 20260812 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 9 DP - 2025 Nov 14 TI - Sleep and Activity Patterns as Transdiagnostic Behavioral Biomarkers in Psychiatry: Longitudinal Observational Study From the DeeP-DD Study. PG - e81107 LID - 10.2196/81107 [doi] LID - e81107 AB - BACKGROUND: Despite widespread use of symptom rating scales in psychiatry, these tools are limited by reliance on self-report, infrequent administration, and lack of predictive power. This constrains clinicians' ability to monitor illness trajectories or anticipate adverse outcomes like relapse. Actigraphy, a passive wearable-based method for measuring sleep and physical activity, offers objective, high-resolution behavioral data that may better reflect symptom fluctuations. Prior research has shown associations between actigraphy features and mood or psychosis symptoms, but most studies have focused on narrow diagnostic groups or fixed time windows, limiting clinical translation. OBJECTIVE: This study aims to examine whether actigraphy-derived sleep and activity features correlate with psychiatric symptom severity in a transdiagnostic psychiatric sample, and to identify which features are most clinically relevant across multiple temporal resolutions. METHODS: We present a feasibility case series study analyzing preliminary data from 8 outpatients (ages 18-52 years) enrolled in the Deep Phenotyping and Digitalization at Douglas (DeeP-DD) study, a prospective transdiagnostic study of digital phenotyping. Participants wore wrist-based actigraphy devices (GENEActiv) for up to 5 months. Symptom severity was measured using a variety of self- and clinician-rated scales. We performed intraindividual Spearman correlations and interindividual repeated measures correlations across daily, weekly, monthly, and full-duration averages. RESULTS: Intraindividual analyses revealed that later rise times were significantly associated with higher weekly 9-item Patient Health Questionnaire (PHQ-9) scores in participant 7 (rho=0.74, P<.001) and participant 4 (rho=0.78, P=.02), as well as higher weekly 7-item General Anxiety Disorder (GAD-7) scores in participant 7 (rho=0.59, P=.03). While similar trends were observed at daily and monthly timescales, the weekly resolution yielded the most robust significance. Interindividual analyses showed that weeks with later average rise time correlated with higher PHQ-9 (r=0.48, P<.001) and GAD-7 scores (r=0.38, P=.03), with the PHQ-9 association remaining significant after Bonferroni correction (Bonferroni-corrected P=.02). Increased light physical activity was linked to lower PHQ-9 scores weekly (r=-0.44, P=.001) and monthly (r=-0.53, P=.01). Over the whole duration of the study, increased levels of sedentary activity were associated with lower GAD-7 scores (rho=0.74; P<.001). CONCLUSIONS: Our findings highlight actigraphy-derived sleep and activity features, particularly rise time and physical activity, as promising transdiagnostic markers of psychiatric symptom burden. Their consistent associations across temporal scales and diagnostic groups underscore their potential utility for scalable, real-world clinical monitoring. Future work should validate these findings in larger cohorts and explore advanced analytical methods to capture circadian rhythmicity and symptom dynamics more precisely. CI - (c) Dylan Hamitouche, Tihare Zamorano, Youcef Barkat, Deven Parekh, Lena Palaniyappan, Sara Jalali, David Benrimoh. Originally published in JMIR Formative Research (https://formative.jmir.org). FAU - Hamitouche, Dylan AU - Hamitouche D AUID- ORCID: 0009-0002-9912-9295 AD - Douglas Mental Health University Institute, 6875 LaSalle boulevard, Verdun, QC, H4H 1R3, Canada, 1 514-239-0428. AD - Department of Medicine, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada. FAU - Zamorano, Tihare AU - Zamorano T AUID- ORCID: 0009-0001-4911-4194 AD - Douglas Mental Health University Institute, 6875 LaSalle boulevard, Verdun, QC, H4H 1R3, Canada, 1 514-239-0428. AD - Integrated Program in Neuroscience (IPN), Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada. FAU - Barkat, Youcef AU - Barkat Y AUID- ORCID: 0009-0002-9019-1105 AD - Douglas Mental Health University Institute, 6875 LaSalle boulevard, Verdun, QC, H4H 1R3, Canada, 1 514-239-0428. AD - Department of Biochemistry, Faculty of Medicine, Universite de Montreal, Montreal, QC, Canada. FAU - Parekh, Deven AU - Parekh D AUID- ORCID: 0009-0004-6138-2791 AD - Douglas Mental Health University Institute, 6875 LaSalle boulevard, Verdun, QC, H4H 1R3, Canada, 1 514-239-0428. FAU - Palaniyappan, Lena AU - Palaniyappan L AUID- ORCID: 0000-0003-1640-7182 AD - Douglas Mental Health University Institute, 6875 LaSalle boulevard, Verdun, QC, H4H 1R3, Canada, 1 514-239-0428. AD - Department of Psychiatry, McGill University, Montreal, QC, Canada. AD - Robarts Research Institute, Western University, London, ON, Canada. AD - Department of Psychology, McGill University, Montreal, QC, Canada. FAU - Jalali, Sara AU - Jalali S AUID- ORCID: 0009-0008-4501-2132 AD - Douglas Mental Health University Institute, 6875 LaSalle boulevard, Verdun, QC, H4H 1R3, Canada, 1 514-239-0428. FAU - Benrimoh, David AU - Benrimoh D AUID- ORCID: 0000-0002-1452-4791 AD - Douglas Mental Health University Institute, 6875 LaSalle boulevard, Verdun, QC, H4H 1R3, Canada, 1 514-239-0428. AD - Department of Psychiatry, McGill University, Montreal, QC, Canada. LA - eng PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20251114 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Adult MH - Male MH - *Actigraphy/methods MH - Female MH - Longitudinal Studies MH - Middle Aged MH - *Sleep/physiology MH - Adolescent MH - Young Adult MH - *Exercise/physiology MH - Biomarkers MH - *Mental Disorders/diagnosis/physiopathology MH - Prospective Studies MH - Feasibility Studies MH - Severity of Illness Index PMC - PMC12617961 OTO - NOTNLM OT - actigraphy OT - digital biomarkers OT - digital phenotyping OT - physical activity OT - sleep COIS- Conflicts of Interest: DB is a founder and shareholder of Aifred Health, a digital mental health company. Aifred Health was not involved in this research. LP reports personal fees for serving as chief editor from the Canadian Medical Association Journal, speaker honorarium from Janssen Canada and Otsuka Canada, SPMM Course Limited, UK; book royalties from Oxford University Press; and investigator-initiated educational grants from Otsuka Canada outside the submitted work in the last 5 years. EDAT- 2025/11/14 18:27 MHDA- 2025/11/14 18:28 PMCR- 2025/11/14 CRDT- 2025/11/14 15:42 PHST- 2025/07/28 00:00 [received] PHST- 2025/10/22 00:00 [revised] PHST- 2025/10/23 00:00 [accepted] PHST- 2025/11/14 18:28 [medline] PHST- 2025/11/14 18:27 [pubmed] PHST- 2025/11/14 15:42 [entrez] PHST- 2025/11/14 00:00 [pmc-release] AID - v9i1e81107 [pii] AID - 81107 [pii] AID - 10.2196/81107 [doi] PST - epublish SO - JMIR Form Res. 2025 Nov 14;9:e81107. doi: 10.2196/81107. PMID- 41237154 OWN - NLM STAT- MEDLINE DCOM- 20251114 LR - 20251117 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 11 DP - 2025 TI - Usability evaluation of the "Teen 'n Fit" mobile health application: A formative study among Indonesian adolescent girls. PG - e0337013 LID - 10.1371/journal.pone.0337013 [doi] LID - e0337013 AB - BACKGROUND: Mobile Health (mHealth) Applications offer a promising approach to promote the adoption of healthy nutrition and behavior among adolescent girls. A tailored mobile app, Teen 'n Fit, was developed to support adolescent girls in Indonesia to assess their nutritional status, physical activity, and eating behavior; as a nutrition education media; and as a reminder of iron folic acid consumption. However, it is essential to measure the app's usability prior to the release. OBJECTIVE: This study aimed to measure the usability of a mobile application designed to promote nutrition and healthy behavior of adolescent girls by modifying the mHealth App Usability Questionnaire (MAUQ). METHODS: A cross-sectional usability study was conducted on 64 adolescent girls aged 15-18 from a public high school in Depok, Indonesia. Participants completed app-based tasks and filled out a post-task usability questionnaire. The usability questionnaire was adapted from a validated MAUQ for a standalone mHealth app. The exploratory factor analysis was conducted to determine the items constituting each component in the modified MAUQ. Mann-Whitney analysis was employed to analyze the difference in usability score means based on participants' characteristics. RESULTS: The modified MAUQ demonstrated strong reliability (Cronbach's alpha = 0.945). The app achieves a strong usability score, 6.0 +/- 0.8 out of 7, with 79.7 percent of participants reporting no prior mHealth experience. The score among participants who occasionally used mHealth applications was higher (p = 0.046) than those who had never made prior use. CONCLUSION: The findings indicate strong usability potential of Teen 'n Fit as a digital health promotion tool for adolescent girls; however, future efforts in conducting effectiveness tests and maintaining user engagement are needed. CI - Copyright: (c) 2025 Kumala Putri et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Kumala Putri, Dwi Sisca AU - Kumala Putri DS AUID- ORCID: 0000-0003-1926-9328 AD - Research Center for Public Health and Nutrition, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia. FAU - Sari, Kencana AU - Sari K AUID- ORCID: 0000-0003-1382-1492 AD - Research Center for Public Health and Nutrition, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia. FAU - Utami, Nur Handayani AU - Utami NH AUID- ORCID: 0000-0003-4113-9394 AD - Research Center for Public Health and Nutrition, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia. FAU - Nazarina, Nazarina AU - Nazarina N AD - Research Center for Public Health and Nutrition, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia. FAU - Amelia, Tiara AU - Amelia T AD - Faculty of Public Health, Universitas Indonesia, Depok, Indonesia. FAU - Salwa, Nadira Yuthie AU - Salwa NY AD - Faculty of Public Health, Universitas Indonesia, Depok, Indonesia. FAU - Sulistiyowati, Ning AU - Sulistiyowati N AUID- ORCID: 0009-0004-7631-699X AD - Research Center for Public Health and Nutrition, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia. FAU - Ega, Adindra Vickar AU - Ega AV AD - Research Center for Equipment Manufacturing Technology, Research Organization for Energy and Manufacture, National Research and Innovation Agency, Tangerang Selatan, Indonesia. FAU - Azzumar, Muhammad AU - Azzumar M AD - Research Center for Electrical Technology, Research Organization for Energy and Manufacture, National Research and Innovation Agency, Tangerang Selatan, Indonesia. FAU - Rachmawati, Rika AU - Rachmawati R AUID- ORCID: 0000-0003-2800-6706 AD - Research Center for Public Health and Nutrition, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia. FAU - Salimar AU - Salimar AUID- ORCID: 0009-0006-8530-8830 AD - Research Center for Public Health and Nutrition, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia. FAU - Despitasari, Mieska AU - Despitasari M AUID- ORCID: 0000-0002-3553-7794 AD - Research Center for Preclinical and Clinical Medicine, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia. FAU - Mulyantoro, Donny Kristanto AU - Mulyantoro DK AUID- ORCID: 0000-0002-4103-8473 AD - Research Center for Public Health and Nutrition, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia. LA - eng PT - Journal Article DEP - 20251114 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Adolescent MH - Humans MH - Female MH - Indonesia MH - *Mobile Applications MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - Telemedicine MH - Health Promotion/methods MH - Exercise MH - Nutritional Status MH - Health Behavior PMC - PMC12617895 COIS- The authors have declared that no competing interests exist. EDAT- 2025/11/14 18:26 MHDA- 2025/11/14 18:27 PMCR- 2025/11/14 CRDT- 2025/11/14 13:43 PHST- 2025/05/26 00:00 [received] PHST- 2025/11/03 00:00 [accepted] PHST- 2025/11/14 18:27 [medline] PHST- 2025/11/14 18:26 [pubmed] PHST- 2025/11/14 13:43 [entrez] PHST- 2025/11/14 00:00 [pmc-release] AID - PONE-D-25-24785 [pii] AID - 10.1371/journal.pone.0337013 [doi] PST - epublish SO - PLoS One. 2025 Nov 14;20(11):e0337013. doi: 10.1371/journal.pone.0337013. eCollection 2025. PMID- 41236572 OWN - NLM STAT- Publisher LR - 20251114 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) DP - 2025 Nov 14 TI - Comparative Evaluation of Measurement Methods for Positional Skull Deformities in Infants: A Prospective Analysis. LID - 10.1097/SCS.0000000000012119 [doi] AB - BACKGROUND: The incidence of positional skull deformities in infants has increased following campaigns promoting supine sleeping to reduce SIDS. Although various measurement methods exist to quantify cranial asymmetries, discrepancies between direct anthropometry, 3-dimensional photogrammetry, and plagiocephalometry may lead to differing severity classifications and treatment indications. Comparison of the available measurement protocols is crucial to harmonize assessment of these deformities. OBJECTIVE: To prospectively compare 3 measurement techniques-caliper-based (spreading caliper and measuring tape), 3D photogrammetry, and plagiocephalometry-for evaluating cranial deformity in early infancy, to assess their reproducibility and their individual impact on clinical decision-making. METHODS: In a prospective study, 51 infants aged 3 to 12 months were examined during an outpatient "helmet consultation." Each infant underwent measurements using: (1) standardized direct anthropometry (caliper and tape measurement), (2) 3D photogrammetry with a multicamera system and subsequent semiautomated analysis via the Software Cranioform Analytics 4.0, and (3) plagiocephalometry (PCM) using a thermoplastic strip technique and indirect measurement. Key indices-the cephalic index (CI) and cranial vault asymmetry index (CVAI) (or ODDI for plagiocephalometry)-were calculated. For PCM, a variance component analysis was performed to assess inter- and intraobserver variability. Bland-Altman analyses were used to compare CI and CVAI/ODDI values among the methods, treatment cutoffs were evaluated. RESULTS: Since reproducibility for caliper measurements was already tested for inter- and intraobserver variability, this method was defined "gold standard" at our center. The treatment threshold for this analytical method was a CVA >/= 1.0 cm. 3D photogrammetry-with a treatment cutoff at values above the 97th percentile of normative values-demonstrated excellent reproducibility with minimal bias (systematic error in CI of -0.77), whereas plagiocephalometry-with predefined cutoffs-exhibited a slightly higher bias in CI (-1.35). Cranial vault asymmetry index values varied-also due to differing calculation methods described in the available literature. Variance component analysis of plagiocephalometry indicated interobserver and intraobserver contributions below 3%. Discrepancies in measurement planes, angles, and index calculation furthermore led to differences in treatment indications: caliper screening identified more infants with an indication for orthotic treatment for deformational plagiocephaly than did the other 2 methods. CONCLUSION: While all 3 techniques provide valuable information, caliper measurement remains a rapid, cost-effective, and fast screening tool. Subsequent evaluation with 3D photogrammetry is recommended for treatment planning. Plagiocephalometry-although provided with high intra- and interrater reliablity-offers no significant advantages in daily practice. Standardization of measurement landmarks and definition of index calculation is needed to internationally standardize and harmonize clinical decision-making. CI - Copyright (c) 2025 by Mutaz B. Habal, MD. FAU - Wilbrand, Jan-Falco AU - Wilbrand JF AD - Department of Cranio-Maxillofacial Surgery, Dr. Jan-Falco Wilbrand, Diakonie Klinikum, Siegen, Germany. FAU - Kruger, Richard AU - Kruger R AD - Department of Cranio-Maxillofacial Surgery, University Hospital Giessen, Dr. Hans-Peter Howaldt, Giessen, Germany. FAU - Pons-Kuehnemann, Jorn AU - Pons-Kuehnemann J AD - Department of medical statistics, University Hospital Giessen, Dr. Jorn Pons-Kuehnemann, Giessen, Germany. FAU - Hp, Howaldt AU - Hp H AD - Department of Cranio-Maxillofacial Surgery, University Hospital Giessen, Dr. Hans-Peter Howaldt, Giessen, Germany. FAU - Wilbrand, Martina AU - Wilbrand M AD - Department of Cranio-Maxillofacial Surgery, University Hospital Giessen, Dr. Hans-Peter Howaldt, Giessen, Germany. LA - eng PT - Journal Article DEP - 20251114 PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 SB - IM OTO - NOTNLM OT - 3D photogrammetry OT - cephalic index OT - infant skull deformity OT - plagiocephalometry OT - plagiocephaly COIS- The authors report no conflicts of interest. EDAT- 2025/11/14 12:33 MHDA- 2025/11/14 12:33 CRDT- 2025/11/14 11:03 PHST- 2025/08/22 00:00 [received] PHST- 2025/09/16 00:00 [accepted] PHST- 2025/11/14 12:33 [medline] PHST- 2025/11/14 12:33 [pubmed] PHST- 2025/11/14 11:03 [entrez] AID - 00001665-990000000-03388 [pii] AID - 10.1097/SCS.0000000000012119 [doi] PST - aheadofprint SO - J Craniofac Surg. 2025 Nov 14. doi: 10.1097/SCS.0000000000012119. PMID- 41236463 OWN - NLM STAT- MEDLINE DCOM- 20251221 LR - 20251221 IS - 1532-6586 (Electronic) IS - 0161-4754 (Linking) VI - 48 IP - 6-9 DP - 2025 Jul-Dec TI - Reliability of a Visual-Cognitive Technology in Measuring Reaction Times: Associations with Age, Activity Level, and Grip Strength. PG - 789-799 LID - S0161-4754(25)00078-8 [pii] LID - 10.1016/j.jmpt.2025.10.054 [doi] AB - OBJECTIVES: The purpose of this study was to assess the reliability of a visual-cognitive system for measuring simple, serial, and choice reaction times, and examined their associations with age, physical activity, and grip strength. METHODS: Ninety participants were divided into 3 age groups (18-34, 35-64, and 65+ years). Reaction times were assessed using a commercially available visual-cognitive training platform. Grip strength was measured with a hand dynamometer, and activity level was evaluated using the International Physical Activity Questionnaire-Short Form (IPAQ-SF). RESULTS: Choice reaction times differed significantly by age, with younger adults responding faster than older adults (P < .05). Simple and serial reaction times were also shortest in the youngest group. Significant associations were found between reaction times, age, and activity level (P < .05), with no significant differences by sex (P > .05). Intra-rater reliability was highest for simple reaction time (ICC = 0.70-0.80), followed by choice (ICC = 0.66-0.76) and serial (ICC = 0.62-0.73). Between-day reliability was good for simple (ICC = 0.81) and serial (ICC = 0.76) reaction times, and moderate for choice (ICC = 0.63). Inter-rater reliability was good across all measures (ICCs >/= 0.70). CONCLUSIONS: Choice reaction time appears to be particularly sensitive to age-related differences. Higher activity levels and greater grip strength are associated with faster responses. The tested visual-cognitive technology demonstrated acceptable reliability for assessing performance-related reaction times. CI - Copyright (c) 2025. Published by Elsevier Inc. FAU - Saldiran, Tulay Cevik AU - Saldiran TC AD - Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Bitlis Eren University, Bitlis, Turkey. Electronic address: tlyfztcvk@gmail.com. FAU - Tanhan, Abdurrahman AU - Tanhan A AD - Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Bitlis Eren University, Bitlis, Turkey. FAU - Celikel, Rabia AU - Celikel R AD - Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Bitlis Eren University, Bitlis, Turkey. FAU - Dincer, Erhan AU - Dincer E AD - Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Bitlis Eren University, Bitlis, Turkey; Department of Physiology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey. LA - eng PT - Journal Article DEP - 20251113 PL - United States TA - J Manipulative Physiol Ther JT - Journal of manipulative and physiological therapeutics JID - 7807107 SB - IM MH - Humans MH - *Hand Strength/physiology MH - *Reaction Time/physiology MH - Male MH - Female MH - Adult MH - Reproducibility of Results MH - Middle Aged MH - Aged MH - Young Adult MH - Age Factors MH - Adolescent MH - *Cognition/physiology OTO - NOTNLM OT - Aged OT - Attention OT - Perception OT - Reaction time OT - Reproducibility of results EDAT- 2025/11/14 12:32 MHDA- 2025/12/22 00:28 CRDT- 2025/11/14 10:27 PHST- 2024/12/26 00:00 [received] PHST- 2025/09/30 00:00 [revised] PHST- 2025/10/13 00:00 [accepted] PHST- 2025/12/22 00:28 [medline] PHST- 2025/11/14 12:32 [pubmed] PHST- 2025/11/14 10:27 [entrez] AID - S0161-4754(25)00078-8 [pii] AID - 10.1016/j.jmpt.2025.10.054 [doi] PST - ppublish SO - J Manipulative Physiol Ther. 2025 Jul-Dec;48(6-9):789-799. doi: 10.1016/j.jmpt.2025.10.054. Epub 2025 Nov 13. PMID- 41234462 OWN - NLM STAT- MEDLINE DCOM- 20251114 LR - 20251116 IS - 1303-6165 (Electronic) IS - 1300-0144 (Print) IS - 1300-0144 (Linking) VI - 55 IP - 5 DP - 2025 TI - Cultural adaptation and psychometric characteristics of the child oral and motor proficiency scale (ChOMPS)-Turkish version. PG - 1141-1150 LID - 10.55730/1300-0144.6069 [doi] AB - BACKGROUND/AIM: The child oral and motor proficiency scale (ChOMPS) is a parent-reported assessment that evaluates a child's eating and drinking skills within the framework of all related motor functions. It has been found to be useful in research studies and recommended in reviews. The purpose of this study was to perform the translation and cultural adaptation of the English version of the ChOMPS to Turkish and conduct psychometric testing of the ChOMPS-Turkish version, including reliability and validity. MATERIALS AND METHODS: This study was conducted with 185 children. Cronbach's alpha, corrected item-to-total correlations, coefficient of variation, and Cronbach's alpha when one item was deleted were used to assess internal consistency. In addition, test-retest reliability was assessed. The functional oral intake scale (FOIS) and pediatric eating assessment tool-10 (Pedi-EAT-10) scales were used for convergent validity. Moreover, Pedi-EAT-10 score was used to perform the receiver operating characteristic (ROC) curve analysis and the sensitivity and specificity of ChOMPS-Turkish version were calculated. RESULTS: It was found that the ChOMPS-Turkish version demonstrated acceptable validity and reliability. Cronbach's alpha levels were excellent (0.969 and 0.973), and test-retest reliability demonstrated very high agreement (0.997-0.999; p < 0.001). Significant good-to-excellent correlations were found between the validation scales. In addition, the total ChOMPS-Turkish version score for dysphagia risk as estimated using Pedi-EAT-10 had 94.74% sensitivity and 80.28% specificity. CONCLUSION: The ChOMPS-Turkish version demonstrates strong evidence of validity and reliability for use in clinical practice and research. CI - (c) TUBITAK. FAU - Umay, Ebru AU - Umay E AUID- ORCID: 0000-0002-4137-7731 AD - Department of Physical Medicine and Rehabilitation, Etlik Physical Medicine and Rehabilitation City Hospital, Ankara, Turkiye. FAU - Eyigor, Sibel AU - Eyigor S AUID- ORCID: 0000-0002-9781-2712 AD - Department of Physical Medicine and Rehabilitation, Ege University Faculty of Medicine, Izmir, Turkiye. FAU - Cankurtaran, Damla AU - Cankurtaran D AUID- ORCID: 0000-0002-6208-3345 AD - Department of Physical Medicine and Rehabilitation, Etlik Physical Medicine and Rehabilitation City Hospital, Ankara, Turkiye. FAU - Kalkan, Sema AU - Kalkan S AUID- ORCID: 0000-0001-9574-7841 AD - Department of Pediatric Metabolism, Ege University Faculty of Medicine, Izmir, Turkiye. FAU - Tezel, Nihal AU - Tezel N AUID- ORCID: 0000-0002-7623-7827 AD - Department of Physical Medicine and Rehabilitation, Etlik Physical Medicine and Rehabilitation City Hospital, Ankara, Turkiye. FAU - Uz, Cuma AU - Uz C AUID- ORCID: 0000-0001-5277-0101 AD - Department of Physical Medicine and Rehabilitation, Etlik Physical Medicine and Rehabilitation City Hospital, Ankara, Turkiye. FAU - Guzel, Sukran AU - Guzel S AUID- ORCID: 0000-0001-9852-0917 AD - Department of Physical Medicine and Rehabilitation, Etlik Physical Medicine and Rehabilitation City Hospital, Ankara, Turkiye. FAU - Balli Uz, Fatma AU - Balli Uz F AUID- ORCID: 0000-0001-8666-1034 AD - Department of Physical Medicine and Rehabilitation, Etlik Physical Medicine and Rehabilitation City Hospital, Ankara, Turkiye. FAU - Gozpinar, Guler AU - Gozpinar G AUID- ORCID: 0000-0002-3167-5057 AD - Department of Physical Medicine and Rehabilitation, Etlik Physical Medicine and Rehabilitation City Hospital, Ankara, Turkiye. FAU - Gayir, Recep AU - Gayir R AUID- ORCID: 0000-0002-3279-3186 AD - Department of Physical Medicine and Rehabilitation, Erdemli State Hospital, Mersin, Turkiye. FAU - Nazli, Fatma AU - Nazli F AUID- ORCID: 0000-0001-5383-2175 AD - Department of Physical Medicine and Rehabilitation, Kirklareli University Faculty of Medicine, Kirklareli, Turkiye. FAU - Demirsoz, Kerim AU - Demirsoz K AUID- ORCID: 0000-0003-3050-1191 AD - Department of Physical Medicine and Rehabilitation, Etlik Physical Medicine and Rehabilitation City Hospital, Ankara, Turkiye. FAU - Unlu Akyuz, Ece AU - Unlu Akyuz E AUID- ORCID: 0000-0003-4718-5981 AD - Department of Physical Medicine and Rehabilitation, Etlik Physical Medicine and Rehabilitation City Hospital, Ankara, Turkiye. FAU - Pados, Britt AU - Pados B AUID- ORCID: 0000-0002-8016-2370 AD - Infant Feeding Care, Wellesley, Massachusetts, United States of America. LA - eng PT - Journal Article DEP - 20250713 PL - Turkey TA - Turk J Med Sci JT - Turkish journal of medical sciences JID - 9441758 SB - IM MH - Humans MH - *Psychometrics MH - Reproducibility of Results MH - Male MH - Female MH - Child MH - Turkey MH - *Motor Skills/physiology MH - Child, Preschool MH - Translations MH - Surveys and Questionnaires MH - *Eating/physiology PMC - PMC12611375 OTO - NOTNLM OT - ChOMPS OT - Deglutition OT - children OT - reliability OT - validity COIS- Disclosure of potential conflicts of interest: There is no conflict of interest among the authors. EDAT- 2025/11/14 06:28 MHDA- 2025/11/14 06:29 PMCR- 2025/07/13 CRDT- 2025/11/14 04:36 PHST- 2025/05/09 00:00 [received] PHST- 2025/10/14 00:00 [revised] PHST- 2025/07/13 00:00 [accepted] PHST- 2025/11/14 06:29 [medline] PHST- 2025/11/14 06:28 [pubmed] PHST- 2025/11/14 04:36 [entrez] PHST- 2025/07/13 00:00 [pmc-release] AID - tjmed-55-05-1141 [pii] AID - 10.55730/1300-0144.6069 [doi] PST - epublish SO - Turk J Med Sci. 2025 Jul 13;55(5):1141-1150. doi: 10.55730/1300-0144.6069. eCollection 2025. PMID- 41231832 OWN - NLM STAT- MEDLINE DCOM- 20260329 LR - 20260329 IS - 1940-1019 (Electronic) IS - 0022-3980 (Linking) VI - 160 IP - 4 DP - 2026 TI - The Relationship Between College Students' Perceived Social Support and Life Satisfaction: A Chain Mediation Effect of Physical Activity and Self-Control. PG - 405-420 LID - 10.1080/00223980.2025.2585272 [doi] AB - BACKGROUND: Life satisfaction is a key indicator of college students' quality of life, and social support has a positive effect on it, but specific mechanisms need to be explored. This study aimed to analyze the relationship between perceived social support and life satisfaction among college students, as well as the chain-mediated effects of physical activity and self-control in this relationship. METHODS: A cross-sectional design was used in this study, involving 613 samples. The Perceived Social Support Scale (PSSS), Physical Activity Rating Scale (PARS-3), Brief Self-Control Scale (BSCS), and Single-Issue Life Satisfaction Scale were employed. Validation factor analysis, Harman's single-factor test, descriptive statistics, correlation analysis, and mediation effect analysis were conducted using AMOS 24.0 and SPSS 27.0 software. RESULTS: The results of the study showed that perceived social support not only directly affects college students' life satisfaction but also indirectly affects their life satisfaction through two independent mediating mechanisms, namely physical activity and self-control, as well as a chain mediating effect (i.e., social support --> physical activity --> self-control). CONCLUSION: Students who perceive more support tend to have higher life satisfaction, partly because it promotes physical activity and enhances self-control. This finding provides a theoretical basis for interventions in universities and families, suggesting that support for college students should be strengthened through various means to promote their healthy development. FAU - Nie, Yuyang AU - Nie Y AD - Beijing Normal University. FAU - Wang, Wenlei AU - Wang W AD - Beijing Normal University. FAU - Wang, Tianci AU - Wang T AD - Ningxia University School of Physical Education. FAU - Zhou, Fangbing AU - Zhou F AD - Beijing Normal University. FAU - Liu, Cong AU - Liu C AD - Beijing Normal University. FAU - Gao, Jinchao AU - Gao J AD - Beijing Normal University. LA - eng PT - Journal Article DEP - 20251113 PL - United States TA - J Psychol JT - The Journal of psychology JID - 0376332 SB - IM MH - Humans MH - *Personal Satisfaction MH - Female MH - Male MH - *Students/psychology MH - *Social Support MH - Young Adult MH - Cross-Sectional Studies MH - *Exercise/psychology MH - Universities MH - Adult MH - *Self-Control/psychology MH - Adolescent OTO - NOTNLM OT - College students OT - life satisfaction OT - mediating effects OT - physical activity OT - self-control OT - social support EDAT- 2025/11/13 18:29 MHDA- 2026/03/30 00:29 CRDT- 2025/11/13 13:43 PHST- 2026/03/30 00:29 [medline] PHST- 2025/11/13 18:29 [pubmed] PHST- 2025/11/13 13:43 [entrez] AID - 10.1080/00223980.2025.2585272 [doi] PST - ppublish SO - J Psychol. 2026;160(4):405-420. doi: 10.1080/00223980.2025.2585272. Epub 2025 Nov 13. PMID- 41231156 OWN - NLM STAT- MEDLINE DCOM- 20251207 LR - 20251207 IS - 1879-1972 (Electronic) IS - 1054-139X (Linking) VI - 78 IP - 1 DP - 2026 Jan TI - Evaluation of the Quality, Reliability, and Readability of ChatGPT-4 Responses on Exercise and Rehabilitation Strategies for Adolescent Myositis. PG - 183-189 LID - S1054-139X(25)00443-4 [pii] LID - 10.1016/j.jadohealth.2025.09.015 [doi] AB - PURPOSE: The study aims to evaluate the ability of ChatGPT-4 to generate reliable and accurate responses concerning exercise and rehabilitation strategies for adolescent patients with myositis. METHODS: Seventy frequently asked questions related to exercise and rehabilitation in adolescent myositis were developed and classified into 7 thematic categories. Information reliability was assessed using the modified DISCERN (mDISCERN) tool, quality was evaluated with the Global Quality Scale (GQS), accuracy was measured using a five-point Likert scale, and readability was assessed with the Flesch Reading Ease scale. Two independent physiotherapists with expertise in rheumatologic rehabilitation independently evaluated the responses. RESULTS: The mDISCERN scale scores ranged from 3 to 3.67, with a mean of 3.36. The GQS scores varied from 3.46 to 5.0, with a mean of 3.86. Accuracy scale scores ranged from 3.9 to 5.0, with a mean of 4.26. The Flesch Reading Ease scores ranged from 42.92 to 55.61, with a mean of 47.79. The intraclass correlation coefficients for the mDISCERN, GQS, and accuracy scales were 0.773, 0.712, and 0.710, respectively. DISCUSSION: This study emphasized that ChatGPT-4 responses regarding adolescent myositis are generally accurate, with moderate to good reliability. However, the high reading level, requiring college-level education, may limit accessibility. These limitations underscore the need for healthcare professionals to supervise exercise planning and for further development of domain-specific AI models with enhanced reliability and readability. CI - Copyright (c) 2025 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved. FAU - Sari, Fulden AU - Sari F AD - Department of Physiotherapy and Rehabilitation, Faculty of Physical Therapy and Rehabilitation, Bingol University, Bingol, Turkey. Electronic address: fuldensari@hotmail.com. FAU - Celik, Zeliha AU - Celik Z AD - Department of Physiotherapy and Rehabilitation, Amasya University Faculty of Health Science, Amasya, Turkey. LA - eng PT - Journal Article DEP - 20251113 PL - United States TA - J Adolesc Health JT - The Journal of adolescent health : official publication of the Society for Adolescent Medicine JID - 9102136 SB - IM MH - Humans MH - Adolescent MH - *Myositis/rehabilitation MH - Reproducibility of Results MH - Female MH - Male MH - Surveys and Questionnaires/standards MH - *Exercise Therapy/methods MH - *Comprehension MH - *Exercise MH - Generative Artificial Intelligence OTO - NOTNLM OT - Artificial intelligence OT - ChatGPT4 OT - Chatbot OT - Education OT - Exercise OT - Patient information OT - Readability OT - Rheumatic diseases EDAT- 2025/11/13 12:32 MHDA- 2025/12/08 01:37 CRDT- 2025/11/13 10:27 PHST- 2025/05/11 00:00 [received] PHST- 2025/09/07 00:00 [revised] PHST- 2025/09/19 00:00 [accepted] PHST- 2025/12/08 01:37 [medline] PHST- 2025/11/13 12:32 [pubmed] PHST- 2025/11/13 10:27 [entrez] AID - S1054-139X(25)00443-4 [pii] AID - 10.1016/j.jadohealth.2025.09.015 [doi] PST - ppublish SO - J Adolesc Health. 2026 Jan;78(1):183-189. doi: 10.1016/j.jadohealth.2025.09.015. Epub 2025 Nov 13. PMID- 41230641 OWN - NLM STAT- MEDLINE DCOM- 20260528 LR - 20260811 IS - 1461-7277 (Electronic) IS - 1359-1053 (Linking) VI - 31 IP - 7 DP - 2026 Jun TI - Validation of orthorexia nervosa scales in late adolescent women: Orthorexia Nervosa Revised Scale, Teruel Orthorexia Scale, and Dusseldorf Orthorexia Nervosa Revised Scale. PG - 2759-2773 LID - 10.1177/13591053251389832 [doi] AB - This study evaluated the psychometric properties of three orthorexia measures, Orthorexia Nervosa Revised Scale (ORTO-R), Teruel Orthorexia Scale (TOS), and Dusseldorf Orthorexia Scale (DOS), in 1337 Croatian women aged 18 to 21. Participants also completed eating disorder measures (EAT-26, DEAS-S). Confirmatory factor analysis tested structural validity. The TOS (two-factor: chi(2)/df = 9.40, CFI = 0.951, TLI = 0.943, RMSEA = 0.079, SRMR = 0.070) and DOS (single-factor: chi(2)/df = 10.68, CFI = 0.980, TLI = 0.972, RMSEA = 0.085, SRMR = 0.037) showed good fit and strong reliability (TOS omega = 0.85/0.89; DOS omega = 0.86), with associations with eating disorder symptoms, supporting convergent validity. In contrast, the ORTO-R showed weaker reliability (omega = 0.60) and, despite modifications improving some indices (CFI = 0.953, TLI = 0.912, SRMR = 0.044), retained high RMSEA (0.116), indicating limitations. Overall, the TOS and DOS appear reliable tools for assessing orthorexia, whereas the ORTO-R demonstrates psychometric weaknesses. FAU - Blazev, Divna AU - Blazev D AUID- ORCID: 0009-0008-9837-0216 AD - Institute of Social Sciences Ivo Pilar, Zagreb, Croatia. FAU - Lauri Korajlija, Anita AU - Lauri Korajlija A AD - University of Zagreb, Croatia. LA - eng PT - Journal Article PT - Validation Study DEP - 20251113 PL - England TA - J Health Psychol JT - Journal of health psychology JID - 9703616 SB - IM MH - *Orthorexia Nervosa/diagnosis/psychology MH - Croatia MH - *Feeding Behavior/psychology MH - Surveys and Questionnaires MH - Factor Analysis, Statistical MH - Psychometrics MH - Reproducibility of Results MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Humans MH - Female MH - Adolescent MH - Young Adult OTO - NOTNLM OT - Dusseldorf Orthorexia Scale OT - ORTO-R Scale OT - Teruel Orthorexia Scale OT - orthorexia OT - orthorexia nervosa COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/11/13 06:29 MHDA- 2026/05/21 12:36 CRDT- 2025/11/13 05:33 PHST- 2026/05/21 12:36 [medline] PHST- 2025/11/13 06:29 [pubmed] PHST- 2025/11/13 05:33 [entrez] AID - 10.1177/13591053251389832 [doi] PST - ppublish SO - J Health Psychol. 2026 Jun;31(7):2759-2773. doi: 10.1177/13591053251389832. Epub 2025 Nov 13. PMID- 41229170 OWN - NLM STAT- MEDLINE DCOM- 20260102 LR - 20260112 IS - 2040-1124 (Electronic) IS - 2040-1116 (Print) IS - 2040-1116 (Linking) VI - 17 IP - 1 DP - 2026 Jan TI - Dual-center prospective validation of an early second-trimester predictive model integrating BMI trajectories and pathophysiological biomarkers for gestational diabetes risk stratification. PG - 150-164 LID - 10.1111/jdi.70179 [doi] AB - OBJECTIVE: To develop and validate an early second-trimester predictive model integrating body mass index (BMI) trajectories and pathophysiological biomarkers for gestational diabetes mellitus (GDM) risk stratification, with the aim of reducing weight-monitoring frequency while maintaining predictive accuracy. METHODS: In this prospective dual-center cohort study, 1,450 pregnant women (<12 weeks gestation) without preexisting diabetes were enrolled from two Beijing maternal-child hospitals. Serial anthropometric (BMI at 6-10, 12-14, 15-19, and 24-28 weeks) and metabolic biomarkers (fasting glucose, C-peptide, lipids, uric acid) were analyzed. GDM was diagnosed via 75 g OGTT at 24-28 weeks. Multivariable logistic regression identified predictors using a 7:3 training-test split. Model performance was assessed by area under the ROC curve (AUC), calibration, and decision curve analysis. RESULTS: GDM incidence was 26.1% (378/1,450). Significant weight/BMI disparities emerged as early as 6-10 weeks (GDM vs NGT: +2.3 kg, P < 0.0001), escalating through gestation. The final model incorporated age (OR = 1.07/year, 95% CI = 1.03-1.11), 12-14-week BMI (OR = 1.06/kg/m(2), 1.01-1.12), fasting glucose (OR = 1.86/mmol/L, 1.45-2.40), fasting C-peptide (OR = 1.87/ng/mL, 1.28-2.73). The model demonstrated moderate discrimination (training AUC = 0.684; testing AUC = 0.685) with 63.7-67.2% sensitivity and 59.8-61.4% specificity at the optimal threshold (0.237). Negative predictive values exceeded 82%, enabling effective risk exclusion. CONCLUSIONS: This dual-center model pioneers GDM risk stratification by 12-14 weeks using clinically accessible metrics, reducing weight-monitoring frequency without compromising prognostic value. While AUC limitations (0.68-0.69) suggest unmeasured contributors, its operational simplicity and robust negative predictive capacity support implementation in resource-constrained settings. The findings redefine antenatal care paradigms by shifting focus to early metabolic dysregulation rather than late diagnostic thresholds. CI - (c) 2025 The Author(s). Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. FAU - Gao, Junxiang AU - Gao J AD - Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China. FAU - Song, Shuoning AU - Song S AD - Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China. FAU - Duo, Yanbei AU - Duo Y AD - Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China. FAU - Qiao, Xiaolin AU - Qiao X AD - Department of Obstetrics, Beijing Chaoyang District Maternal and Child Health Care Hospital, Beijing, China. FAU - Zhang, Yuemei AU - Zhang Y AD - Department of Obstetrics, Haidian District Maternal and Child Health Care Hospital, Beijing, China. FAU - Xu, Jiyu AU - Xu J AD - Core Facility of Instrument, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China. FAU - Zhang, Jing AU - Zhang J AD - Department of Laboratory, Haidian District Maternal and Child Health Care Hospital, Beijing, China. FAU - Nie, Xiaorui AU - Nie X AD - Department of Obstetrics, Beijing Chaoyang District Maternal and Child Health Care Hospital, Beijing, China. FAU - Sun, Qiujin AU - Sun Q AD - Department of Clinical Laboratory, Beijing Chaoyang District Maternal and Child Health Care Hospital, Beijing, China. FAU - Yang, Xianchun AU - Yang X AD - Department of Clinical Laboratory, Beijing Chaoyang District Maternal and Child Health Care Hospital, Beijing, China. FAU - Wang, Ailing AU - Wang A AD - National Center for Women and Children's Health, Chinese Center for Disease Control and Prevention, Beijing, China. FAU - Sun, Wei AU - Sun W AD - Core Facility of Instrument, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China. FAU - Fu, Yong AU - Fu Y AD - Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China. FAU - Zhang, Mengmeng AU - Zhang M AD - Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China. FAU - Dong, Yingyue AU - Dong Y AD - Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China. FAU - Lu, Zechun AU - Lu Z AD - National Center for Women and Children's Health, Chinese Center for Disease Control and Prevention, Beijing, China. FAU - Yuan, Tao AU - Yuan T AD - Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China. FAU - Zhao, Weigang AU - Zhao W AD - Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China. LA - eng GR - 2019ZX09734001/Weigang Zhao/ PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20251112 PL - Japan TA - J Diabetes Investig JT - Journal of diabetes investigation JID - 101520702 RN - 0 (Biomarkers) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Diabetes, Gestational/diagnosis/epidemiology/blood MH - Prospective Studies MH - Adult MH - *Biomarkers/blood/analysis MH - *Body Mass Index MH - *Pregnancy Trimester, Second/blood MH - Risk Assessment/methods MH - Risk Factors MH - Prognosis MH - Blood Glucose/analysis MH - Follow-Up Studies PMC - PMC12757667 OTO - NOTNLM OT - BMI trajectories OT - Early prediction model OT - Gestational diabetes mellitus COIS- The authors declare no conflict of interest. Approval of the research protocol: The study was conducted in accordance with the guidelines of the Declaration of Helsinki. The study protocol was obtained from Haidian District Maternal and Child Health Care Hospital and Chaoyang District Maternal and Child Health Care Hospital (Beijing, China). Informed consent: Informed consent to participate in the study was obtained from all study participants. The Ethical Review Committee of the National Center for Women and Children's Health, Chinese Center for Disease Control and Prevention in Beijing, China, approved this study on April 3, 2019 (approval number: FY2019-01). Registry and the registration no. of the study/trial: 2015-10-20, ClinicalTrials.gov identifier: NCT03246295. Animal studies: N/A. EDAT- 2025/11/13 06:29 MHDA- 2026/01/02 06:28 PMCR- 2025/11/12 CRDT- 2025/11/13 02:23 PHST- 2025/08/28 00:00 [revised] PHST- 2025/04/29 00:00 [received] PHST- 2025/10/01 00:00 [accepted] PHST- 2026/01/02 06:28 [medline] PHST- 2025/11/13 06:29 [pubmed] PHST- 2025/11/13 02:23 [entrez] PHST- 2025/11/12 00:00 [pmc-release] AID - JDI70179 [pii] AID - 10.1111/jdi.70179 [doi] PST - ppublish SO - J Diabetes Investig. 2026 Jan;17(1):150-164. doi: 10.1111/jdi.70179. Epub 2025 Nov 12. PMID- 41228555 OWN - NLM STAT- MEDLINE DCOM- 20251113 LR - 20251116 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 21 DP - 2025 Nov 5 TI - Assessment of Eating Attitudes and Body Image Among 17-20-Year-Olds Engaged in Regular Sports Activity. LID - 10.3390/nu17213482 [doi] LID - 3482 AB - BACKGROUND/OBJECTIVES: Eating disorders (EDs) and body image disturbances are increasingly recognized as important health issues among young athletes. Sports participation may both support healthy development and simultaneously increase vulnerability to disordered eating due to performance pressures and cultural ideals. The aim of this study was to assess the risk of eating disorders and body image among 17-20-year-old athletes. METHODS: The study included 428 participants (215 women and 213 men) actively engaged in sports. Standardized psychometric tools were applied, including the Eating Attitudes Test (EAT-26) and the Body Esteem Scale (BES). Statistical analyses examined differences across gender, BMI categories, and sports disciplines, as well as predictors of ED risk. RESULTS: The analysis showed that 32.9% (n = 141; 95% CI: 28.3-37.8%) of respondents were at risk of developing eating disorders, with women being significantly more vulnerable than men (p < 0.001; V = 0.27). Underweight athletes demonstrated a higher risk compared with those of normal weight (OR = 2.86, 95% CI: 1.48-5.55, p < 0.001). The type of sport was also associated with risk (p < 0.001, V = 0.323); the highest prevalence of ED risk occurred among dancers (48.1%) and swimmers (38.9%). Body esteem differed markedly between groups: participants at risk scored lower in Weight Control (p < 0.001, Cohen's d = 0.94) and Physical Attractiveness (p = 0.072) but higher in Physical Condition (p < 0.001). Regression analyses indicated that gender (beta = -3.35, p < 0.001) and Body Esteem-Weight Control (beta = -0.45, p < 0.001) were the strongest predictors of EAT-26 scores. CONCLUSIONS: The findings confirm the multidimensional nature of eating disorder risk among young athletes, highlighting the role of body image imbalance and gender differences. Early screening, preventive interventions, and multidisciplinary support are essential to protect both the physical and mental health of young athletes. Future research should include objective physiological measures and broader samples to improve generalizability. FAU - Biedron, Martyna AU - Biedron M AD - Department of Health Promotion, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, Ul. Piekarska 18, 41-902 Bytom, Poland. FAU - Jaruga-Sekowska, Sylwia AU - Jaruga-Sekowska S AUID- ORCID: 0000-0003-0142-2013 AD - Department of Health Promotion, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, Ul. Piekarska 18, 41-902 Bytom, Poland. FAU - Kloda, Martyna AU - Kloda M AD - Department of Physical Activity and Health Promotion, Academy of Physical Education in Katowice, Mikolowska 72a, 40-065 Katowice, Poland. FAU - Staskiewicz-Bartecka, Wiktoria AU - Staskiewicz-Bartecka W AUID- ORCID: 0000-0003-2420-5935 AD - Department of Food Technology and Quality Evaluation, Department of Dietetics, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland. FAU - Wozniak-Holecka, Joanna AU - Wozniak-Holecka J AD - Department of Health Promotion, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, Ul. Piekarska 18, 41-902 Bytom, Poland. LA - eng PT - Journal Article DEP - 20251105 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Male MH - *Body Image/psychology MH - *Feeding and Eating Disorders/epidemiology/psychology MH - Young Adult MH - *Athletes/psychology MH - Adolescent MH - *Sports/psychology MH - Body Mass Index MH - *Feeding Behavior/psychology MH - Risk Factors MH - Sex Factors MH - Surveys and Questionnaires MH - Prevalence PMC - PMC12610256 OTO - NOTNLM OT - BMI OT - adolescence OT - athletes OT - body esteem scale OT - eating disorders OT - sports psychology COIS- The authors declare no conflicts of interest. EDAT- 2025/11/13 06:29 MHDA- 2025/11/13 18:30 PMCR- 2025/11/05 CRDT- 2025/11/13 01:11 PHST- 2025/09/23 00:00 [received] PHST- 2025/10/31 00:00 [revised] PHST- 2025/11/03 00:00 [accepted] PHST- 2025/11/13 18:30 [medline] PHST- 2025/11/13 06:29 [pubmed] PHST- 2025/11/13 01:11 [entrez] PHST- 2025/11/05 00:00 [pmc-release] AID - nu17213482 [pii] AID - nutrients-17-03482 [pii] AID - 10.3390/nu17213482 [doi] PST - epublish SO - Nutrients. 2025 Nov 5;17(21):3482. doi: 10.3390/nu17213482. PMID- 41228551 OWN - NLM STAT- MEDLINE DCOM- 20251113 LR - 20251210 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 21 DP - 2025 Nov 5 TI - A Systematic Review of the Correlation Between Micronutrient Levels and Perinatal Depression. LID - 10.3390/nu17213479 [doi] LID - 3479 AB - BACKGROUND: Depression is a significant complication of the peripartum period that can result in profound long-term detrimental implications for the affected woman, her child, and her family. It is possible that micronutrient imbalances could contribute to the development of perinatal depression through their roles in neurotransmitter synthesis and neuroendocrine and neuroimmune pathways. Micronutrient imbalances are more likely during the perinatal period due to the additional physiological demands on the body during this time. The objective of this systematic review was to review and summarise the existing evidence regarding the association between micronutrient levels and perinatal depression. METHODS: MEDLINE, EMBASE, PsycINFO, CINAHL, Scopus, and Web of Science were searched for studies examining blood levels of micronutrients and assessment of depression within the peripartum period using validated rating tools. RESULTS: A total of 58 studies met the eligibility criteria and were included in this review. Of these, 31 studies reported a significant inverse association between perinatal depression and at least one of the following: vitamin D, iron status, vitamin B12, folate, or zinc. Vitamin D was the most frequently investigated nutrient, examined in 28 of the 58 articles. The remaining 27 did not demonstrate a significant association. CONCLUSION: This review found that vitamin D deficiency has the greatest evidence of an association with perinatal depression. The evidence for other micronutrients is mixed, inconclusive, or limited. Further research is required to determine the significance of these micronutrients in the development of perinatal depression. FAU - Islam, Nabilah AU - Islam N AD - Centre for Genomics and Personalised Health, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia. FAU - Semmler, Annalese AU - Semmler A AUID- ORCID: 0000-0002-2084-4986 AD - School of Clinical Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia. FAU - Starling, Jean AU - Starling J AD - Campbelltown Hospital, Ambarvale, NSW 2560, Australia. FAU - Voisey, Joanne AU - Voisey J AUID- ORCID: 0000-0001-6645-6164 AD - Centre for Genomics and Personalised Health, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia. LA - eng PT - Journal Article PT - Systematic Review DEP - 20251105 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Micronutrients) RN - J41CSQ7QDS (Zinc) RN - 1406-16-2 (Vitamin D) SB - IM MH - Humans MH - *Micronutrients/blood/deficiency MH - Female MH - Pregnancy MH - *Depression/blood/etiology MH - Peripartum Period MH - Nutritional Status MH - *Pregnancy Complications/blood MH - *Depression, Postpartum/blood/etiology MH - Zinc/blood MH - Vitamin D Deficiency/blood/complications MH - Vitamin D/blood PMC - PMC12610701 OTO - NOTNLM OT - biomarkers OT - maternal mental health OT - micronutrients OT - perinatal depression OT - postpartum depression OT - vitamin D COIS- The authors declare no conflicts of interest. EDAT- 2025/11/13 06:29 MHDA- 2025/11/13 18:29 PMCR- 2025/11/05 CRDT- 2025/11/13 01:11 PHST- 2025/09/16 00:00 [received] PHST- 2025/10/27 00:00 [revised] PHST- 2025/10/31 00:00 [accepted] PHST- 2025/11/13 18:29 [medline] PHST- 2025/11/13 06:29 [pubmed] PHST- 2025/11/13 01:11 [entrez] PHST- 2025/11/05 00:00 [pmc-release] AID - nu17213479 [pii] AID - nutrients-17-03479 [pii] AID - 10.3390/nu17213479 [doi] PST - epublish SO - Nutrients. 2025 Nov 5;17(21):3479. doi: 10.3390/nu17213479. PMID- 41228528 OWN - NLM STAT- MEDLINE DCOM- 20251113 LR - 20251116 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 21 DP - 2025 Nov 1 TI - Breakfast Consumption and Its Association with Insulin Resistance in a Large-Scale Cohort of Children and Adolescents with Overweight/Obesity in Greece. LID - 10.3390/nu17213457 [doi] LID - 3457 AB - Introduction: Breakfast skipping has been proposed as a determinant of childhood obesity and disorders of glucose metabolism. The present study aimed to examine the association between breakfast skipping and insulin resistance in children and adolescents with overweight or obesity. Methods: In total, 1291 children aged 2-18 years old (boys = 48.4%, boys with obesity = 69.8%; girls = 51.6%, girls with obesity = 60.8%) participated in the study, providing sociodemographic, anthropometric, lifestyle, biochemical, and clinical data. Breakfast consumption was assessed using a validated questionnaire. The IOTF criteria were used to categorize children's body mass index (BMI) status, while the homeostasis model assessment (HOMA-IR) was used to assess insulin resistance. Results: According to the findings of this study, 37.3% of the children/adolescents were found to skip daily breakfast consumption. Girls tended to skip breakfast more than boys (40.5% vs. 33.9%, p = 0.016), with the percentage of girls skipping breakfast increasing in the older age groups (2-5 yrs: 27% vs. 6-12 yrs: 39.1% vs. 13-18 yrs: 53.5%, p = 0.001). Linear regression analyses showed that breakfast skipping is associated with HOMA-IR in the total sample and in children and adolescents with obesity, after adjusting for several confounding factors (age, gender, Tanner stage, residency, and sports participation). Conclusions: A large number of children and adolescents with overweight or obesity, especially adolescent girls, skip daily breakfast consumption, which was associated with insulin resistance. These findings underscore the importance of promoting regular breakfast consumption as a preventive strategy against metabolic complications in children and adolescents with overweight or obesity. FAU - Androutsos, Odysseas AU - Androutsos O AUID- ORCID: 0000-0002-2849-1994 AD - Laboratory of Clinical Nutrition and Dietetics, Department of Nutrition and Dietetics, University of Thessaly, 42132 Trikala, Greece. FAU - Manou, Maria AU - Manou M AUID- ORCID: 0000-0002-9584-0373 AD - Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, "Aghia Sophia" Children's Hospital, National and Kapodistrian University of Athens Medical School, 11527 Athens, Greece. FAU - Kalafati, Ioanna Panagiota AU - Kalafati IP AUID- ORCID: 0000-0001-5572-7491 AD - Laboratory of Clinical Nutrition and Dietetics, Department of Nutrition and Dietetics, University of Thessaly, 42132 Trikala, Greece. FAU - Kipouros, Michail AU - Kipouros M AUID- ORCID: 0000-0002-8485-2299 AD - Laboratory of Clinical Nutrition and Dietetics, Department of Nutrition and Dietetics, University of Thessaly, 42132 Trikala, Greece. FAU - Georgiou, Alexandra AU - Georgiou A AD - Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, "Aghia Sophia" Children's Hospital, National and Kapodistrian University of Athens Medical School, 11527 Athens, Greece. FAU - Charmandari, Evangelia AU - Charmandari E AUID- ORCID: 0000-0002-0851-6998 AD - Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, "Aghia Sophia" Children's Hospital, National and Kapodistrian University of Athens Medical School, 11527 Athens, Greece. AD - Division of Endocrinology and Metabolism, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece. LA - eng PT - Journal Article DEP - 20251101 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - *Insulin Resistance MH - *Breakfast MH - Male MH - Female MH - Adolescent MH - Greece/epidemiology MH - *Pediatric Obesity/epidemiology MH - Child, Preschool MH - *Overweight MH - *Feeding Behavior MH - Body Mass Index MH - Cohort Studies PMC - PMC12608924 OTO - NOTNLM OT - breakfast OT - children OT - insulin resistance OT - obesity COIS- The authors declare no conflicts of interest. EDAT- 2025/11/13 06:29 MHDA- 2025/11/13 18:30 PMCR- 2025/11/01 CRDT- 2025/11/13 01:11 PHST- 2025/09/27 00:00 [received] PHST- 2025/10/30 00:00 [revised] PHST- 2025/10/31 00:00 [accepted] PHST- 2025/11/13 18:30 [medline] PHST- 2025/11/13 06:29 [pubmed] PHST- 2025/11/13 01:11 [entrez] PHST- 2025/11/01 00:00 [pmc-release] AID - nu17213457 [pii] AID - nutrients-17-03457 [pii] AID - 10.3390/nu17213457 [doi] PST - epublish SO - Nutrients. 2025 Nov 1;17(21):3457. doi: 10.3390/nu17213457. PMID- 41228473 OWN - NLM STAT- MEDLINE DCOM- 20251113 LR - 20251212 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 21 DP - 2025 Oct 29 TI - Prediction of Gestational Diabetes Mellitus: A Nomogram Model Incorporating Lifestyle, Nutrition and Health Literacy Factors. LID - 10.3390/nu17213400 [doi] LID - 3400 AB - Background: Over the past several decades, the prevalence of gestational diabetes mellitus (GDM) has risen markedly worldwide, posing serious threats to both maternal and child health by increasing adverse pregnancy outcomes and long-term metabolic risks. Developing effective risk prediction tools for early detection and intervention has become the most important clinical priority in this field. The current GDM prediction models primarily rely on non-modifiable factors, for example age and body mass index, while modifiable factors such as lifestyle and health literacy, although strongly associated with GDM, have not been fully utilized in risk assessment. This study sought to establish and validate a nomogram prediction model combining modifiable and non-modifiable risk factors, with the goal of identifying high-risk Chinese pregnant women with GDM at an early stage and promoting targeted prevention and personalized prenatal management. Methods: A multicenter study was conducted across 7 maternal health institutions in Southern China (2021-2023), enrolling 806 singleton pregnant women (14-23(+6) weeks). The collected data included sociodemographic, clinical history, and modifiable factors collected through validated questionnaires: dietary quality, physical activity level, sleep quality, and nutrition and health literacy. GDM was diagnosed via 75 g oral glucose tolerance test at 24-28 weeks. Predictive factors were identified through multi-variable logistic regression. A nomogram model was developed (70% modeling group) and validated (30% validation group). Receiver operator characteristic curves, calibration curves, and decision curve analysis were used to evaluate the prediction ability, the degree of calibration, and the clinical benefit of the model, respectively. Results: The finalized risk prediction model included non-modifiable factors such as maternal age, pre-pregnancy weight, and maternal polycystic ovary syndrome, as well as modifiable factors including dietary quality, physical activity level, sleep quality, nutrition and health literacy. The application of the nomogram in the modeling group and the validation groups showed that the model had high stability, favorable predictive ability, good calibration effect and clinical practicality. Conclusions: Overall, the integrated model demonstrates significant clinical utility as it facilitates the prompt identification of individuals at heightened risk and offers actionable targets for personalized interventions. In terms of future implementation, this model can be integrated into prenatal care as a rapid scoring table during early pregnancy consultations or incorporated into mobile health applications. This approach fosters precise prevention strategies for GDM in maternal health by emphasizing nutrition and health literacy, supplemented by coordinated adjustments in diet, physical activity, and sleep. FAU - Fu, Minghan AU - Fu M AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China. FAU - Qiu, Menglu AU - Qiu M AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China. FAU - Xie, Zhencheng AU - Xie Z AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China. FAU - Guo, Laidi AU - Guo L AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China. FAU - Zhou, Yun AU - Zhou Y AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China. FAU - Yin, Jia AU - Yin J AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China. FAU - Yang, Wanyi AU - Yang W AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China. FAU - Ouyang, Lishan AU - Ouyang L AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China. FAU - Ding, Ye AU - Ding Y AUID- ORCID: 0000-0002-7732-3073 AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China. FAU - Wang, Zhixu AU - Wang Z AUID- ORCID: 0000-0002-1633-6313 AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China. AD - The Institute of Nutrition and Food Science, Nanjing Medical University, Nanjing 211166, China. LA - eng GR - 82173503/National Natural Science Foundation of China/ GR - 2019FY101001/National Program on Basic Research Project of China/ PT - Journal Article PT - Multicenter Study DEP - 20251029 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - *Diabetes, Gestational/diagnosis/epidemiology MH - Pregnancy MH - *Health Literacy/statistics & numerical data MH - *Nomograms MH - Adult MH - *Life Style MH - China/epidemiology MH - Risk Factors MH - *Nutritional Status MH - Risk Assessment/methods MH - Glucose Tolerance Test PMC - PMC12610468 OTO - NOTNLM OT - Chinese pregnant women OT - gestational diabetes mellitus OT - lifestyle OT - nutrition and health literacy OT - prediction model COIS- The authors declare no conflict of interest. EDAT- 2025/11/13 06:29 MHDA- 2025/11/13 18:29 PMCR- 2025/10/29 CRDT- 2025/11/13 01:11 PHST- 2025/10/07 00:00 [received] PHST- 2025/10/27 00:00 [revised] PHST- 2025/10/28 00:00 [accepted] PHST- 2025/11/13 18:29 [medline] PHST- 2025/11/13 06:29 [pubmed] PHST- 2025/11/13 01:11 [entrez] PHST- 2025/10/29 00:00 [pmc-release] AID - nu17213400 [pii] AID - nutrients-17-03400 [pii] AID - 10.3390/nu17213400 [doi] PST - epublish SO - Nutrients. 2025 Oct 29;17(21):3400. doi: 10.3390/nu17213400. PMID- 41228450 OWN - NLM STAT- MEDLINE DCOM- 20251113 LR - 20251116 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 21 DP - 2025 Oct 28 TI - Intergenerational Transmission of Proactive Health Behaviors Among Adolescents with Overweight or Obesity: The Mediating Role of Self-Efficacy and Family Cohesion. LID - 10.3390/nu17213377 [doi] LID - 3377 AB - Background/Objectives: The family environment exerts a significant influence on the development of weight-related behaviors among adolescents. However, the lack of motivation often leads to failure in sustaining health behaviors, particularly among adolescents with overweight and obesity. This study examined whether parental healthy behaviors are associated with proactive health behaviors among adolescents with overweight and obesity and investigated the mediating roles of adolescents' self-efficacy and family cohesion in these relationships within Chinese families. Methods: We recruited 4932 adolescents with overweight and obesity aged 10 to 15 in Shandong Province between October and December 2024. Participants completed validated questionnaires assessing parental healthy behaviors, self-efficacy, family cohesion, and proactive health behaviors. We analyzed the data using multilevel regression models and mediation analysis, controlling for key sociodemographic factors. Subgroup analyses were conducted by gender and region level. Results: Both fathers' (beta = 0.442, 95% CI = 0.263, 0.620) and mothers' (beta = 0.525, 95% CI = 0.336, 0.714) healthy behaviors were positively associated with proactive health behaviors among adolescents with overweight and obesity in the adjusted model. Further mediation analysis revealed that adolescent self-efficacy and family cohesion significantly mediated these relationships. Conclusions: This work suggested that parental healthy behaviors were positively associated with proactive health behaviors among adolescents with overweight and obesity. Additionally, higher self-efficacy and family cohesion enhance these associations. The findings offered evidence-based recommendations for creating family-centered interventions targeting adolescents with overweight and obesity. Future research should employ longitudinal designs to understand these relationships better and improve the efficacy of family-based interventions for adolescents with overweight and obesity. FAU - Hu, Tian AU - Hu T AD - School of Nursing, Qingdao University, 308 Ningxia Road, Qingdao 266071, China. FAU - Zhou, Jingwei AU - Zhou J AD - Qingdao Municipal Key Laboratory for Smart Healthcare and Chronic Disease Management, Qingdao 266071, China. FAU - Yu, Lianlong AU - Yu L AUID- ORCID: 0000-0002-6631-5254 AD - Shandong Center for Disease Control and Prevention, 16992 Jingshi Road, Jinan 250014, China. FAU - Li, Suyun AU - Li S AD - Shandong Center for Disease Control and Prevention, 16992 Jingshi Road, Jinan 250014, China. FAU - Leong, Qian Ning AU - Leong QN AD - School of Nursing, National University of Singapore, Singapore 117597, Singapore. FAU - Li, Jingjing AU - Li J AD - School of Nursing, Qingdao University, 308 Ningxia Road, Qingdao 266071, China. FAU - Zhou, Yunping AU - Zhou Y AUID- ORCID: 0000-0001-6132-7590 AD - School of Nursing, Qingdao University, 308 Ningxia Road, Qingdao 266071, China. FAU - Jiang, Ying AU - Jiang Y AD - School of Nursing, National University of Singapore, Singapore 117597, Singapore. LA - eng GR - 82504533/National Natural Science Foundation of China/ GR - ZR2025MS1145/Shandong Provincial Natural Science Foundation/ PT - Journal Article DEP - 20251028 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Self Efficacy MH - Adolescent MH - Female MH - Male MH - *Health Behavior MH - *Pediatric Obesity/psychology MH - *Overweight/psychology MH - Child MH - Surveys and Questionnaires MH - China MH - *Adolescent Behavior/psychology MH - *Family Relations/psychology MH - *Parent-Child Relations PMC - PMC12610138 OTO - NOTNLM OT - adolescents OT - family cohesion OT - intergenerational transmission OT - obesity OT - proactive health behaviors OT - self-efficacy COIS- The authors declare no conflicts of interest. EDAT- 2025/11/13 06:29 MHDA- 2025/11/13 12:32 PMCR- 2025/10/28 CRDT- 2025/11/13 01:11 PHST- 2025/10/01 00:00 [received] PHST- 2025/10/22 00:00 [revised] PHST- 2025/10/24 00:00 [accepted] PHST- 2025/11/13 12:32 [medline] PHST- 2025/11/13 06:29 [pubmed] PHST- 2025/11/13 01:11 [entrez] PHST- 2025/10/28 00:00 [pmc-release] AID - nu17213377 [pii] AID - nutrients-17-03377 [pii] AID - 10.3390/nu17213377 [doi] PST - epublish SO - Nutrients. 2025 Oct 28;17(21):3377. doi: 10.3390/nu17213377. PMID- 41228420 OWN - NLM STAT- MEDLINE DCOM- 20251113 LR - 20251116 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 21 DP - 2025 Oct 24 TI - Assessing Appetite-Validation of a Picture-Based Appetite Assessment Tool for Children Aged 6-9 Years-A Pilot Study. LID - 10.3390/nu17213347 [doi] LID - 3347 AB - Background: Recognizing and balancing internal and external appetite cues is critical for controlling food intake in young children. The main aim of this pilot study was to validate a Hebrew-language Picture-Based Appetite Assessment (PBAA) for 6-9-years-old children. Specifically, the scale's ability to reflect changes in perceptions of hunger and satiety based on a story and on their actual eating experiences. Methodology: In Part 1 (n = 99), a PBAA was used to rate a character's hunger level according to a story. In Part 2 (n = 46), the child's hunger level before and after lunch was assessed, and in Part 3 (n = 55), the child's hunger level before and after unrestricted snack consumption was assessed. Results: After hearing a story, participants could identify whether a character in a story was hungry (95%) or full (85%) (Part 1). Their reported appetite levels decreased after consuming lunch (p-value < 0.001) (Part 2). When participants were given unrestricted access to snacks, they preferred highly processed sweets with no difference in hunger level before (Part 3). There were no differences between girls and boys except for the reported satiety after lunch, which was greater in older girls compared to younger girls, yet similar between older and younger boys. Conclusions: Participants successfully interpreted the PBAA scale based on the story character and reported lower hunger after eating lunch. Among girls, older age was associated with a greater difference in hunger levels before and after lunch. Most participants reported satiety after consuming unrestricted snacks, which was not related to their hunger level before. FAU - Eilat-Adar, Sigal AU - Eilat-Adar S AUID- ORCID: 0000-0002-6645-3614 AD - Levinsky-Wingate Academic College, Wingate Campus, Post Graduate Department, Netanya 4290200, Israel. FAU - Zeevi, Yoav AU - Zeevi Y AD - Levinsky-Wingate Academic College, Wingate Campus, Post Graduate Department, Netanya 4290200, Israel. FAU - Shaked, Efrat AU - Shaked E AD - Levinsky-Wingate Academic College, Wingate Campus, Post Graduate Department, Netanya 4290200, Israel. FAU - Rabih, Yael AU - Rabih Y AD - Independent Researcher, Tel Aviv 6291080, Israel. FAU - Zach, Sima AU - Zach S AD - Levinsky-Wingate Academic College, Wingate Campus, Post Graduate Department, Netanya 4290200, Israel. LA - eng PT - Journal Article PT - Validation Study DEP - 20251024 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Pilot Projects MH - Child MH - Female MH - Male MH - *Appetite MH - Hunger MH - Snacks MH - Satiation MH - Lunch MH - Reproducibility of Results MH - Eating MH - *Nutrition Assessment PMC - PMC12608433 OTO - NOTNLM OT - Picture-Based Appetite Assessment tool OT - children aged 6-9 years OT - hunger OT - satiety COIS- The authors declare no conflict of interest. EDAT- 2025/11/13 06:30 MHDA- 2025/11/13 12:30 PMCR- 2025/10/24 CRDT- 2025/11/13 01:11 PHST- 2025/08/25 00:00 [received] PHST- 2025/10/16 00:00 [revised] PHST- 2025/10/17 00:00 [accepted] PHST- 2025/11/13 12:30 [medline] PHST- 2025/11/13 06:30 [pubmed] PHST- 2025/11/13 01:11 [entrez] PHST- 2025/10/24 00:00 [pmc-release] AID - nu17213347 [pii] AID - nutrients-17-03347 [pii] AID - 10.3390/nu17213347 [doi] PST - epublish SO - Nutrients. 2025 Oct 24;17(21):3347. doi: 10.3390/nu17213347. PMID- 41228127 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251113 LR - 20251115 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 13 IP - 21 DP - 2025 Oct 30 TI - Associations Between Body Image Satisfaction, Body Mass Index, Quality of Life, and Screen Time in Portuguese Students. LID - 10.3390/healthcare13212761 [doi] LID - 2761 AB - Background: This study examined the relationship between screen time, body image satisfaction, body mass index (BMI), and quality of life among children and adolescents from two school clusters in Sesimbra, Portugal. Methods: The sample included 80 students aged 10 to 18 years, assessed using validated questionnaires (Collins' Figure Rating Scale and KIDSCREEN-27). Results: Results indicated sex differences in electronic game use, with boys reporting higher usage. A negative association was found between time spent on social networks and perceived autonomy and parent-child relationship quality. A high prevalence of body image dissatisfaction was found, particularly among boys, which was significantly associated with BMI. Regarding quality of life, participants scored lower than the European average in the domains of physical and psychological well-being. Conclusions: Findings suggest that screen time, body image, and BMI interdependently affect quality of life, underscoring the need to promote digital literacy, self-esteem, body acceptance, and healthy lifestyles in both school and family settings. FAU - Silva, Jessica AU - Silva J AD - Instituto Superior de Estudos Interculturais e Transdisciplinares, Instituo Piaget, 2805-059 Almada, Portugal. FAU - Serpa, Joana AU - Serpa J AUID- ORCID: 0000-0002-6321-1353 AD - Insight: Piaget Research Center for Ecological Human Development, Instituto Piaget, 2805-059 Almada, Portugal. FAU - Santos, Vanessa AU - Santos V AUID- ORCID: 0000-0003-2540-2826 AD - Insight: Piaget Research Center for Ecological Human Development, Instituto Piaget, 2805-059 Almada, Portugal. AD - Exercise and Health Laboratory, CIPER, Faculty of Human Kinetics, University of Lisbon, 1495-751 Cruz Quebrada, Portugal. FAU - Vieira, Fernando AU - Vieira F AUID- ORCID: 0000-0001-5630-5135 AD - Insight: Piaget Research Center for Ecological Human Development, Instituto Piaget, 2805-059 Almada, Portugal. FAU - Casanova, Nuno AU - Casanova N AUID- ORCID: 0000-0002-8669-9099 AD - Insight: Piaget Research Center for Ecological Human Development, Instituto Piaget, 2805-059 Almada, Portugal. FAU - Willig, Renata AU - Willig R AUID- ORCID: 0000-0003-1366-0561 AD - Insight: Piaget Research Center for Ecological Human Development, Instituto Piaget, 2805-059 Almada, Portugal. FAU - Flores, Fabio AU - Flores F AUID- ORCID: 0000-0003-3469-3725 AD - Escola de Ciencias Sociais, Universidade de Evora, 7002-554 Evora, Portugal. AD - Centro de Investigacao em Educacao e Psicologia (CIEP), Universidade de Evora, 7002-554 Evora, Portugal. AD - Comprehensive Health Research Centre (CHRC), Universidade de Evora, 7000-645 Evora, Portugal. FAU - Marconcin, Priscila AU - Marconcin P AUID- ORCID: 0000-0002-1295-0826 AD - Insight: Piaget Research Center for Ecological Human Development, Instituto Piaget, 2805-059 Almada, Portugal. AD - Faculty of Health Sciences, Universidad Autonoma de Chile, Providencia 7500912, Chile. LA - eng PT - Journal Article DEP - 20251030 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12607325 OTO - NOTNLM OT - adolescents OT - body image OT - body mass index OT - quality of life OT - screen time COIS- The authors declare no conflicts of interest. EDAT- 2025/11/13 06:28 MHDA- 2025/11/13 06:29 PMCR- 2025/10/30 CRDT- 2025/11/13 01:10 PHST- 2025/09/24 00:00 [received] PHST- 2025/10/23 00:00 [revised] PHST- 2025/10/24 00:00 [accepted] PHST- 2025/11/13 06:29 [medline] PHST- 2025/11/13 06:28 [pubmed] PHST- 2025/11/13 01:10 [entrez] PHST- 2025/10/30 00:00 [pmc-release] AID - healthcare13212761 [pii] AID - healthcare-13-02761 [pii] AID - 10.3390/healthcare13212761 [doi] PST - epublish SO - Healthcare (Basel). 2025 Oct 30;13(21):2761. doi: 10.3390/healthcare13212761. PMID- 41228097 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251113 LR - 20251115 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 13 IP - 21 DP - 2025 Oct 28 TI - The OWL Screening Tool-A Protocol for Holistic Pediatric Lifestyle Assessment. LID - 10.3390/healthcare13212731 [doi] LID - 2731 AB - Background/Objectives: The identification of health risk factors in children should rely not only on body mass index but also on modifiable lifestyle behaviors. Early screening for physical inactivity, poor nutrition, inadequate sleep, and chronic stress is crucial for effective preventive healthcare. The aim of this project was to develop the OWL screening tool, a protocol for the holistic assessment of key lifestyle risk factors in children aged 6-12. Methods/Rationale: The OWL tool was developed by integrating evidence-based recommendations from major health societies (WHO, EFSA, the National Sleep Foundation, and the Pediatric Endocrine Society), incorporating psychological principles, and adapting validated components from existing pediatric screening instruments. Its design prioritizes flexibility for use across various age groups and settings. The development process resulted in the 20-item OWL questionnaire, structured into four lifestyle domains: nutrition, physical activity, sleep, and stress management. Each item is a closed-ended question requiring a dichotomous (yes/no) response. One point is awarded for each health-promoting behavior endorsed, yielding a total possible score of 20. The tool is suitable for self-report by older children, parent-report for younger children, or clinician-administered review. Conclusions: By integrating sleep and stress management with traditional lifestyle factors, the OWL screening tool offers a highly relevant approach to pediatric preventive care. The findings presented here should be interpreted as a proof-of-concept, and the tool is not yet ready for clinical implementation without further rigorous evaluation. FAU - Auffermann, Alina AU - Auffermann A AUID- ORCID: 0000-0002-0184-792X AD - German Clinic, Al Razi Medical Complex, Dubai Healthcare City, Dubai 505055, United Arab Emirates. FAU - Auffermann, Wolfgang AU - Auffermann W AUID- ORCID: 0009-0009-8179-1177 AD - Dr Sulaiman Al Habib Hospital, Dubai Healthcare City, Dubai 505005, United Arab Emirates. LA - eng PT - Journal Article DEP - 20251028 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12609874 OTO - NOTNLM OT - health risk OT - lifestyle OT - pediatric assessment OT - screening OT - tool COIS- The authors declare no conflicts of interest. EDAT- 2025/11/13 06:30 MHDA- 2025/11/13 06:31 PMCR- 2025/10/28 CRDT- 2025/11/13 01:10 PHST- 2025/10/06 00:00 [received] PHST- 2025/10/23 00:00 [revised] PHST- 2025/10/27 00:00 [accepted] PHST- 2025/11/13 06:31 [medline] PHST- 2025/11/13 06:30 [pubmed] PHST- 2025/11/13 01:10 [entrez] PHST- 2025/10/28 00:00 [pmc-release] AID - healthcare13212731 [pii] AID - healthcare-13-02731 [pii] AID - 10.3390/healthcare13212731 [doi] PST - epublish SO - Healthcare (Basel). 2025 Oct 28;13(21):2731. doi: 10.3390/healthcare13212731. PMID- 41226991 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251113 LR - 20251115 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 14 IP - 21 DP - 2025 Oct 26 TI - Magnetic Resonance Imaging-Based Assessment of Bone Marrow Fat and T2 Relaxation in Adolescents with Obesity and Liver Steatosis: A Feasibility Pilot Study. LID - 10.3390/jcm14217594 [doi] LID - 7594 AB - Background: Adolescents suffering from obesity are at higher risk of bone fragility due to hepatic steatosis, which may lead to an inflammatory microenvironment in the bone marrow. We therefore aimed to assess the reliability of measuring the bone marrow fat fraction (BMFF) and T2* of the lumbar vertebral marrow using the proton density fat fraction (PDFF) sequence for adolescents with obesity and liver steatosis. Method: This was an observational feasibility pilot study on adolescents living with obesity and liver steatosis. Anthropometric measurements were obtained. Participants underwent abdominal MRI, MR elastography and dual-energy X-ray absorptiometry (DXA). Regions of interest were drawn using the radiology interface from the central L1 to L4 vertebrae on fat and T2* maps from the PDFF sequence. ImageJ was used to measure abdominal compartment fat areas. Descriptive analyses, the intraclass correlation coefficient, and correlation results were obtained from anthropometric, adiposity, BMFF, and T2* measurements. Results: We recruited 23 adolescents with a body mass index > 85th percentile and mean age = 14.7 years (interval 12-17 years), and n = 18 (78%) were boys. BMFF and T2* measurements were successful in 100% of cases. The intra-operator reproducibility of the BMFF and T2* measurements was excellent: ICC = 0.99 (95% confidence interval (CI) [0.986; 0.999]) and ICC = 0.99 (95% CI [0.992; 0.999]), respectively. The inter-operator ICC was good for BMFF (ICC = 0.89; 95% CI [0.705; 0.963]) and moderate for T2* (ICC = 0.66; 95% CI [0.239; 0.873]). Only BMFF was inversely correlated with vertebral-bone mineral density (r = -0.67; p = 0.0009). However, T2* measurements showed a positive linear relationship with the total body fat tissue percentage measured by DXA (r = 0.48; p = 0.03) and the total abdominal fat area (r = 0.45; p = 0.04). Conclusions: PDFF could be a reliable imaging biomarker for bone health assessment in adolescents living with obesity. FAU - Letissier, Camille AU - Letissier C AUID- ORCID: 0000-0001-7619-9886 AD - Department of Medical Imaging, CHU Sainte-Justine Hospital, Faculty of Medicine, University of Montreal, Montreal, QC H3T 1C5, Canada. FAU - El Ghomari, Kenza AU - El Ghomari K AD - Department of Medical Imaging, CHU Sainte-Justine Hospital, Faculty of Medicine, University of Montreal, Montreal, QC H3T 1C5, Canada. FAU - Gervais, Sylvie AU - Gervais S AD - Departement de Genie Logiciel, Ecole de Technologie Superieure (ETS), Montreal, QC H3C 1K3, Canada. FAU - Ahmarani, Lena AU - Ahmarani L AUID- ORCID: 0000-0001-5087-2569 AD - Department of Medical Imaging, CHU Sainte-Justine Hospital, Faculty of Medicine, University of Montreal, Montreal, QC H3T 1C5, Canada. FAU - El Jalbout, Ramy AU - El Jalbout R AUID- ORCID: 0000-0003-3711-7432 AD - Department of Medical Imaging, CHU Sainte-Justine Hospital, Faculty of Medicine, University of Montreal, Montreal, QC H3T 1C5, Canada. LA - eng GR - 2019-2021/Society for Pediatric Radiology (SPR) Research and Education Foundation/ GR - 2020-2022/Canadian Heads for Academic Radiology (CRF/CHAR)/ PT - Journal Article DEP - 20251026 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC12609853 OTO - NOTNLM OT - adipose tissue OT - adolescent OT - bone density OT - bone marrow OT - dual-energy X-ray absorptiometry OT - nonalcoholic fatty liver disease OT - obesity COIS- The authors declare no conflicts of interest. EDAT- 2025/11/13 12:09 MHDA- 2025/11/13 12:10 PMCR- 2025/10/26 CRDT- 2025/11/13 01:06 PHST- 2025/09/03 00:00 [received] PHST- 2025/10/14 00:00 [revised] PHST- 2025/10/20 00:00 [accepted] PHST- 2025/11/13 12:10 [medline] PHST- 2025/11/13 12:09 [pubmed] PHST- 2025/11/13 01:06 [entrez] PHST- 2025/10/26 00:00 [pmc-release] AID - jcm14217594 [pii] AID - jcm-14-07594 [pii] AID - 10.3390/jcm14217594 [doi] PST - epublish SO - J Clin Med. 2025 Oct 26;14(21):7594. doi: 10.3390/jcm14217594. PMID- 41225473 OWN - NLM STAT- MEDLINE DCOM- 20251113 LR - 20260918 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Nov 12 TI - Associations of Adherence to the 24hour Movement Guidelines with Depressive Symptoms and Anxiety: the Mediating Role of Physical Fitness. PG - 3910 LID - 10.1186/s12889-025-24543-w [doi] LID - 3910 AB - BACKGROUND: Mental health problems such as depression and anxiety were increasingly prevalent among students. Emerging evidence links adherence to 24-hour movement guidelines-including adequate physical activity, limited screen time, and sufficient sleep-with improved mental well-being. However, the mechanisms underlying these associations remained poorly understood. OBJECTIVES: This study aimed to examine the association of adherence to 24-hour movement guidelines with symptoms of depression and anxiety among Chinese students, and to explore the mediating role of perceived fitness in these relationships. METHODS: A cross-sectional survey was conducted among 1674 students (mean age = 11.4 +/- 0.8 years; 47.6% boys) from Chinese elementary schools. 24-hour movement behaviours were assessed using validated self-report measures. Mental health outcomes were measured using the Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder Scale (GAD-7). Perceived fitness was assessed using the International Fitness Scale. Structural equation modelling was used to evaluate direct and indirect pathways, adjusting for relevant covariates. RESULTS: Only 1.4% of participants met all components of the 24-hour movement guidelines. Adherence to the guidelines was significantly associated with lower levels of depressive (beta = -0.125) and anxiety symptoms (beta = -0.107). Perceived fitness was also significantly associated with reduced symptoms of depression (beta = -0.111) and anxiety (beta = -0.049). However, the mediating effects of perceived fitness in both models were minimal or not statistically significant (depression symptoms: beta = 0.002; anxiety symptoms: beta = 0.001). CONCLUSIONS: Better adherence to 24hour movement guidelines was associated with fewer symptoms of depression and anxiety in Chinese students. While perceived fitness was independently linked to improved mental health, its mediating role appears limited. Future studies should incorporate objective fitness assessments and explore additional mediating pathways to fully understand how movement behaviours impact students mental well-being. CI - (c) 2025. The Author(s). FAU - Sun, Qiang AU - Sun Q AD - Sport Science Research Institute, Nanjing Sport Institute, Nanjing, China. FAU - Zhang, Danqing AU - Zhang D AD - Department of Sports and Health Sciences, Academy of Wellness and Human Development, Hong Kong Baptist University, Hong Kong, China. FAU - Ren, Tao AU - Ren T AD - Sport Science Research Institute, Nanjing Sport Institute, Nanjing, China. 33270526@qq.com. LA - eng PT - Journal Article DEP - 20251112 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Male MH - Female MH - Cross-Sectional Studies MH - *Depression/epidemiology MH - *Anxiety/epidemiology MH - China/epidemiology MH - Child MH - *Exercise/psychology MH - *Physical Fitness/psychology MH - *Students/psychology/statistics & numerical data MH - Surveys and Questionnaires MH - *Guideline Adherence/statistics & numerical data PMC - PMC12613720 OTO - NOTNLM OT - 24-hour movement guidelines OT - Anxiety OT - Depression OT - Mediation model OT - Mental health OT - Perceived fitness COIS- Declarations. Ethics approval and consent to participate: The permission to conduct this study was obtained from the teachers and principals of those participating schools. All students participating in the study, and their parents or guardians, were informed and participants were voluntary to take part in this survey. Verbal informed consent was obtained from all parents/guardians or teachers, and positive assent was obtained from all students before data collection which was approved by Institution of Review Board at Nanjing Sport Institute. This study survey was also approved by Institution of Review Board at Nanjing Sport Institute. Procedures performed in studies were in accordance with national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Data were collected and analyzed anonymously. Consent for publication: All authors have approved the manuscript and its submission and publication. Competing interests: The authors declare no competing interests. EDAT- 2025/11/13 00:32 MHDA- 2025/11/13 18:29 PMCR- 2025/11/12 CRDT- 2025/11/12 23:58 PHST- 2025/05/31 00:00 [received] PHST- 2025/08/21 00:00 [accepted] PHST- 2025/11/13 18:29 [medline] PHST- 2025/11/13 00:32 [pubmed] PHST- 2025/11/12 23:58 [entrez] PHST- 2025/11/12 00:00 [pmc-release] AID - 10.1186/s12889-025-24543-w [pii] AID - 24543 [pii] AID - 10.1186/s12889-025-24543-w [doi] PST - epublish SO - BMC Public Health. 2025 Nov 12;25(1):3910. doi: 10.1186/s12889-025-24543-w. PMID- 41224299 OWN - NLM STAT- MEDLINE DCOM- 20251113 LR - 20251115 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 11 DP - 2025 Nov 12 TI - Transgenerational consequences of grandparents' smoking on grandchildren's development: a systematic review. PG - e104977 LID - 10.1136/bmjopen-2025-104977 [doi] LID - e104977 AB - OBJECTIVE: Research on the impact of smoking behaviour across generations has primarily focused on grandmaternal smoking during pregnancy. However, the broader multigenerational effects of smoking behaviour, notably through environmental and behavioural pathways, remain underexplored. This study evaluated previous studies on the possibility of transgenerational transmission, rather than in utero transmission, regarding the effects of grandparental smoking behaviour on offspring's development outcomes. DESIGN: This study is a systematic review with qualitative evidence synthesis. DATA SOURCES: A comprehensive search was conducted across multiple online databases, including PubMed, EBSCOhost, Web of Science and Scopus. To ensure a broad scope of relevant studies, publication dates, study locations and language were restricted to English only. STUDY SELECTION: After duplicates were removed, 3916 articles remained from the 4133 identified articles. Based on the predefined eligibility criteria, 38 articles were selected for full-text assessment. The selection process involved multiple reviewers, with disagreements resolved through consensus. DATA EXTRACTION: Multiple reviewers independently extracted data using a standardised protocol. The Joanna Briggs Institute critical appraisal tool was used to assess the quality of the included studies, with inter-rater reliability tests indicating moderate-to-high agreement. Extracted data included study design, participant demographics, exposure details and measured outcomes. DATA SYNTHESIS: This systematic review included seven studies because of heterogeneity in reported outcomes and effect measures. Three independent reviewers extracted data using a standardised coding sheet. The synthesis compared methodologies, identified gaps, key findings and conclusions across studies. RESULTS: Seven included articles examined grandchildren's behaviour, such as hyperactivity disorder, oppositional defiant disorder and conduct problems, body composition and IQ concerning grandparents' smoking habits. Most studies used robust statistical methods; two included parental factors as mediators. The synthesis of results indicated that the associations were primarily indirect. Key findings revealed that grandparents' smoking status was significantly associated with their grandchildren's physical and cognitive outcomes. Furthermore, the reviewed studies demonstrated sex-specific transgenerational effects of ancestral smoking on grandchildren's health, with stronger effects often observed in male descendants. CONCLUSIONS: This review highlights the methods and findings of previous studies on the potential transgenerational transmissions through which grandparents' smoking behaviour may influence grandchildren's behavioural, physical and cognitive development. Although the findings emphasise the importance of environmental and behavioural factors, further research is needed to address existing gaps and clarify mechanisms. PROTOCOL REGISTRATION: This systematic review protocol was registered in the PROSPERO database under registration number CRD42024571725. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Ratih, Suci Puspita AU - Ratih SP AUID- ORCID: 0000-0003-4380-6154 AD - Department of Social and Preventive Medicine, Faculty of Medicine, Universiti Malaya, Federal Territory of Kuala Lumpur, Malaysia daliana@ummc.edu.my puspita.ratih.fik@um.ac.id. AD - Department of Public Health, Universitas Negeri Malang, Malang, Indonesia. FAU - Choo, Wan Yuen AU - Choo WY AD - Department of Social and Preventive Medicine, Faculty of Medicine, Universiti Malaya, Federal Territory of Kuala Lumpur, Malaysia. FAU - Nik Farid, Nik Daliana AU - Nik Farid ND AD - Department of Social and Preventive Medicine, Faculty of Medicine, Universiti Malaya, Federal Territory of Kuala Lumpur, Malaysia daliana@ummc.edu.my puspita.ratih.fik@um.ac.id. FAU - Romadlona, Nohan Arum AU - Romadlona NA AD - Department of Public Health, Universitas Negeri Malang, Malang, Indonesia. FAU - Humairo, Mika Vernicia AU - Humairo MV AD - Department of Public Health, Universitas Negeri Malang, Malang, Indonesia. FAU - Suprobo, Nina Rini AU - Suprobo NR AD - Department of Midwifery, Universitas Negeri Malang, Malang, Indonesia. LA - eng PT - Journal Article PT - Systematic Review DEP - 20251112 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Grandparents/psychology MH - Child MH - *Smoking/adverse effects MH - Female MH - *Child Development MH - Male MH - Intergenerational Relations PMC - PMC12612766 OTO - NOTNLM OT - EPIDEMIOLOGY OT - PUBLIC HEALTH OT - Tobacco Use COIS- Competing interests: None declared. EDAT- 2025/11/13 00:29 MHDA- 2025/11/13 06:29 PMCR- 2025/11/12 CRDT- 2025/11/12 20:33 PHST- 2025/11/13 06:29 [medline] PHST- 2025/11/13 00:29 [pubmed] PHST- 2025/11/12 20:33 [entrez] PHST- 2025/11/12 00:00 [pmc-release] AID - bmjopen-2025-104977 [pii] AID - 10.1136/bmjopen-2025-104977 [doi] PST - epublish SO - BMJ Open. 2025 Nov 12;15(11):e104977. doi: 10.1136/bmjopen-2025-104977. PMID- 41222490 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260901 IS - 1465-3966 (Electronic) IS - 1354-8506 (Linking) VI - 31 IP - 8 DP - 2026 Sep TI - Sleep health among preconception women: Findings from the PREGO study. PG - 1949-1965 LID - 10.1080/13548506.2025.2587971 [doi] AB - Sleep is particularly critical during the preconception period, as it can impact the health of both women and their potential offspring, but data specifically on preconception sleep health are scarce. The study objective was to document sleep health and its correlates among preconception women. Females (18-45 years) from Canada and who are trying to conceive were recruited to participate in the PREGO Study. Sleep health (duration, quality, and disorders) was measured using the Sleep Health Index. Sociodemographic (age, marital status, level of education, income, ethnic or cultural origins, weight and height), pregnancy-related (gravidity), behavioral (physical activity level, alcohol and caffeine intake, nicotine and cannabis use) and psychological (marital happiness, life satisfaction, depressive and anxiety symptoms, stress, psychological distress) data were self-reported using validated questionnaires. Multivariable linear regression analyses were used to identify correlates of preconception sleep health. Preconception sleep health data were available for 620 women (mean age: 29.9 +/- 3.5 years; 67.6% nulligravid). Participants' global sleep health score was 71.5 +/- 14.4 (out of 100, with higher scores indicating better sleep health) and 81.3% had sleep duration variability between weekdays and weekends. Depression (beta = -1.60; 95% CI: -1.99, -1.22) and life satisfaction (beta = 0.39; 95% CI: 0.11, 0.67) were significant correlates and explained 16% of the variance in sleep health. Preconception women appear to have good overall sleep health, but for many their sleep duration varies between weekdays and weekends. Having higher levels of depressive symptoms was associated with worse sleep health, while good sleep health was associated with higher life satisfaction. It may be worthwhile to ask women wishing to conceive - especially those with depressive symptoms - about their sleep health. These results can be useful for healthcare providers with female patients planning a pregnancy and preconception women who wish to optimize their sleep health as it may benefit both women and their future offspring. FAU - Vezina-Im, Lydi-Anne AU - Vezina-Im LA AUID- ORCID: 0000-0001-9769-9847 AD - VITAM - Research Center in Sustainable Health, Centre integre universitaire de sante et de services sociaux de la Capiale-Nationale, Quebec City, QC, Canada. AD - Department of Health Sciences, Universite du Quebec a Rimouski, Levis, QC, Canada. FAU - Dussault, Priscilla AU - Dussault P AD - Faculty of Education, Universite Laval, Quebec City, QC, Canada. FAU - Van Lieshout, Ryan J AU - Van Lieshout RJ AUID- ORCID: 0000-0001-7244-0222 AD - Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, Canada. FAU - Faleschini, Sabrina AU - Faleschini S AUID- ORCID: 0000-0003-2930-5513 AD - Faculty of Education, Universite Laval, Quebec City, QC, Canada. LA - eng PT - Journal Article DEP - 20251112 PL - England TA - Psychol Health Med JT - Psychology, health & medicine JID - 9604099 SB - IM MH - Humans MH - Female MH - Adult MH - Adolescent MH - Young Adult MH - Depression/epidemiology MH - Canada/epidemiology MH - Sleep Duration MH - Middle Aged MH - *Sleep Quality MH - *Sleep/physiology MH - *Sleep Wake Disorders/epidemiology MH - Stress, Psychological/epidemiology MH - Surveys and Questionnaires MH - *Health Status MH - Personal Satisfaction MH - Anxiety/epidemiology MH - Pregnancy OTO - NOTNLM OT - Sleep OT - depression OT - preconception care OT - women EDAT- 2025/11/12 12:38 MHDA- 2026/09/01 05:41 CRDT- 2025/11/12 10:13 PHST- 2026/09/01 05:41 [medline] PHST- 2025/11/12 12:38 [pubmed] PHST- 2025/11/12 10:13 [entrez] AID - 10.1080/13548506.2025.2587971 [doi] PST - ppublish SO - Psychol Health Med. 2026 Sep;31(8):1949-1965. doi: 10.1080/13548506.2025.2587971. Epub 2025 Nov 12. PMID- 41219910 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251112 LR - 20251114 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 13 IP - 1 DP - 2025 Nov 11 TI - Assessing schema modes for eating disorders and their association with personality traits: validation of the English version of the short form of the schema modes inventory for eating disorders (EN-SMI-ED-SF). PG - 258 LID - 10.1186/s40337-025-01446-0 [doi] LID - 258 AB - BACKGROUND: Schema Therapy is an integrative psychotherapy model with a growing evidence base in the successful treatment of eating disorders (ED). To specifically assess schema modes in ED, the Schema Mode Inventory for Eating Disorders - Short Form (SMI-ED-SF) was developed but its English adaptation is still lacking. OBJECTIVE: The aim of this study is to evaluate the psychometric properties of the English version of the SMI-ED-SF (EN-SMI-ED-SF) within a community sample and to explore its relationship with ED conditions and personality traits. METHOD: An observational design was used, recruiting participants from the general population and specialized clinics for ED treatment. A confirmatory factor analysis was performed to test its factorial structure. A multivariate analysis of variance was conducted to ascertain differences between ED conditions on the dimensions of the EN-SMI-ED-SF. Lastly, the relationship between schema modes and personality traits was explored. RESULTS: The EN-SMI-ED-SF demonstrated excellent fit indices, with robust validity and reliability for measurement of schema modes. Maladaptive schema modes were systematically higher in ED compared to non-ED individuals, and adaptive schema modes were lower in ED groups compared to non-ED individuals. Whereas maladaptive schema modes showed the strongest positive correlations with neuroticism, adaptive modes were strongly correlated with psychological flexibility. DISCUSSION: The EN-SMI-ED-SF demonstrated robust psychometric properties, indicating its validity and reliability for assessment of schema modes. The results provide strong evidence for the role of schema modes in ED pathology, and their association with key personality correlates and the protective function of psychological flexibility. CI - (c) 2025. The Author(s). FAU - Simpson, Susan AU - Simpson S AUID- ORCID: 0000-0002-9625-0797 AD - NHS Forth Valley Eating Disorder Service, Larbert, Scotland, UK. AD - Department of Justice and Society, University of South Australia, Adelaide, Australia. FAU - Rossi, Alessandro Alberto AU - Rossi AA AUID- ORCID: 0000-0001-7000-5999 AD - Department of Philosophy, Sociology, Education, and Applied Psychology, Section of Applied Psychology, University of Padova, Padova, Italy. a.rossi@unipd.it. AD - Center for intervention and Research on Family studies-CIRF, Department of Philosophy, Sociology, Education, and Applied Psychology, Section of Applied Psychology, University of Padova, Padova, Italy. a.rossi@unipd.it. FAU - Mannarini, Stefania AU - Mannarini S AUID- ORCID: 0000-0002-8446-785X AD - Department of Philosophy, Sociology, Education, and Applied Psychology, Section of Applied Psychology, University of Padova, Padova, Italy. AD - Center for intervention and Research on Family studies-CIRF, Department of Philosophy, Sociology, Education, and Applied Psychology, Section of Applied Psychology, University of Padova, Padova, Italy. FAU - Tait, Dorothy AU - Tait D AD - Child and Adolescent Mental Health Service, NHS Western Isles, Glasgow, Scotland. FAU - Castelnuovo, Gianluca AU - Castelnuovo G AUID- ORCID: 0000-0003-2633-9822 AD - Psychology Research Laboratory, Ospedale San Giuseppe, IRCCS Istituto Auxologico Italiano, Verbania, Italy. AD - Department of Psychology, Catholic University of Milan, Milan, Italy. FAU - Pietrabissa, Giada AU - Pietrabissa G AUID- ORCID: 0000-0002-5911-5748 AD - Psychology Research Laboratory, Ospedale San Giuseppe, IRCCS Istituto Auxologico Italiano, Verbania, Italy. AD - Department of Psychology, Catholic University of Milan, Milan, Italy. LA - eng PT - Journal Article DEP - 20251111 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC12606930 OAB - Schema Therapy is an emerging therapy model in the treatment of eating disorders. The short Schema Mode Inventory for Eating Disorders was adapted to measure the 'modes', or cognitive-emotional self-states, as they apply to individuals with eating disorders. This study explored the psychometric properties of this measure in a community sample. The association between schema modes and specific eating disorder conditions and personality traits was investigated. The Schema Mode Inventory for Eating Disorders was found to be a reliable and valid measure. Maladaptive schema modes were higher for people with eating disorders compared with those with no eating disorder. Demanding and Punitive Critic Modes were significantly higher amongst participants with an eating disorder, particularly those with Anorexia Nervosa, highlighting their strong adherence to unrealistic internalized standards and self-criticism. The Eating Disorder Overcontroller, which manifests as body-focused over-control, was strongest in Anorexia and Bulimia Nervosa. Detached Protector and Detached Self Soother were higher for participants with binge eating. Maladaptive schema modes were strongly associated with neuroticism. Adaptive modes were associated with greater psychological flexibility, indicating the value of strengthening the Healthy Adult and Happy child modes within treatments for eating disorders to facilitate adaptive self-regulation of emotionality and psychological flexibility. OABL- eng OTO - NOTNLM OT - Early maladaptive schemas OT - Eating behaviors OT - Eating disorders OT - Personality traits OT - Schema modes OT - Schema modes inventory OT - Schema therapy COIS- Declarations. Ethics approval and consent to participate: Ethics approval was granted by the North of Scotland Research Ethics Committee (REC reference: 18/NS/0046; IRAS project ID: 241811). Informed consent was obtained from all participants. All procedures adhered to the relevant guidelines and regulations. The study described has been carried out following the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/12 00:26 MHDA- 2025/11/12 00:27 PMCR- 2025/11/11 CRDT- 2025/11/11 23:51 PHST- 2025/03/11 00:00 [received] PHST- 2025/10/19 00:00 [accepted] PHST- 2025/11/12 00:27 [medline] PHST- 2025/11/12 00:26 [pubmed] PHST- 2025/11/11 23:51 [entrez] PHST- 2025/11/11 00:00 [pmc-release] AID - 10.1186/s40337-025-01446-0 [pii] AID - 1446 [pii] AID - 10.1186/s40337-025-01446-0 [doi] PST - epublish SO - J Eat Disord. 2025 Nov 11;13(1):258. doi: 10.1186/s40337-025-01446-0. PMID- 41218599 OWN - NLM STAT- MEDLINE DCOM- 20251217 LR - 20251217 IS - 1555-0273 (Electronic) IS - 1555-0265 (Linking) VI - 21 IP - 1 DP - 2026 Jan 1 TI - Assessing the Relationship and Convergent Validity of Player Load and Dynamic Stress Load in Basketball: A Multivariable Regression Analysis. PG - 49-57 LID - 10.1123/ijspp.2025-0300 [doi] AB - PURPOSE: This study aimed to assess the strength of the relationship between Player Load and dynamic stress load (DSL); to evaluate the convergent validity between Player Load, DSL, and other external-load parameters in basketball; and to develop multiple-regression models to explain the relative importance of different external-load parameters to Player Load and DSL. METHODS: Thirteen male basketball players less than 18 years old (age: 16.9 y, height: 198.1 cm, and body mass: 80.2 kg) participated in this study during the 2023-24 season. Players' physical demands were monitored with a local positioning system that was combined with inertial microsensors (WIMU PRO, RealTrack Systems SL). The accelerometer-derived metrics analyzed in this study were Player Load and DSL and other external-load metrics. RESULTS: Player Load and DSL showed a very large repeated-measure relationship, rm_corr = .781. Player Load showed a relationship with total distance (.967, almost perfect), high-speed running (.687, large), acceleration distance (.680, large), and deceleration distance (.661, large). Dynamic stress load showed a significant relationship with total distance (.662, large), high-speed running (.663, large), acceleration distance (.426, moderate), and deceleration distance (.412, moderate). CONCLUSIONS: Player Load and DSL are correlated but not interchangeable. Player Load correlates at least moderately with all external-load measures monitored, with total distance and step count being almost perfect. Although DSL is correlated well with impacts, step count, and jump count over 3 gravitational forces, it correlates to a lesser extent with all metrics. Finally, this study developed 2 multiple-regression models to explain the relative importance of external-load parameters. FAU - Garcia, Franc AU - Garcia F AUID- ORCID: 0000-0001-7126-2284 AD - National Institute of Physical Education of Catalonia (INEFC), University of Barcelona (UB), Barcelona Sport Sciences Research Group, Barcelona, Spain. AD - Sports Performance Area, Futbol Club Barcelona, Barcelona, Spain. FAU - Vicens-Bordas, Jordi AU - Vicens-Bordas J AUID- ORCID: 0000-0002-8388-8863 AD - Sport, Exercise, and Human Movement (SEaHM) and Sport and Physical Activity Studies Centre (CEEAF), University of Vic-Central University of Catalonia, Barcelona, Spain. FAU - Dawson, Laura AU - Dawson L AD - School of Allied Health Sciences, University of Suffolk, Ipswich, United Kingdom. AD - Faculty of Sport, Technology and Health Sciences, St Mary's University, London, United Kingdom. FAU - Jaward, Mohamed Hisham AU - Jaward MH AD - School of Technology, Business and Arts, University of Suffolk, Ipswich, United Kingdom. FAU - Espasa Labrador, Javier AU - Espasa Labrador J AD - National Institute of Physical Education of Catalonia (INEFC), University of Barcelona (UB), Barcelona Sport Sciences Research Group, Barcelona, Spain. AD - Sports Performance Area, Futbol Club Barcelona, Barcelona, Spain. FAU - Beato, Marco AU - Beato M AUID- ORCID: 0000-0001-5373-2211 AD - School of Allied Health Sciences, University of Suffolk, Ipswich, United Kingdom. AD - Department of Neurosciences, Biomedicine and Movement, University of Verona, Verona, Italy. LA - eng PT - Journal Article DEP - 20251111 PL - United States TA - Int J Sports Physiol Perform JT - International journal of sports physiology and performance JID - 101276430 SB - IM MH - Humans MH - Male MH - *Basketball/physiology MH - Adolescent MH - Acceleration MH - *Athletic Performance/physiology MH - Regression Analysis MH - Accelerometry MH - Multivariate Analysis MH - Running/physiology MH - *Stress, Physiological MH - Deceleration OTO - NOTNLM OT - accelerations OT - accelerometers OT - indoor OT - team sports OT - tracking EDAT- 2025/11/12 00:26 MHDA- 2025/12/17 19:11 CRDT- 2025/11/11 18:33 PHST- 2025/06/23 00:00 [received] PHST- 2025/09/22 00:00 [revised] PHST- 2025/09/22 00:00 [accepted] PHST- 2025/12/17 19:11 [medline] PHST- 2025/11/12 00:26 [pubmed] PHST- 2025/11/11 18:33 [entrez] AID - 10.1123/ijspp.2025-0300 [doi] PST - epublish SO - Int J Sports Physiol Perform. 2025 Nov 11;21(1):49-57. doi: 10.1123/ijspp.2025-0300. Print 2026 Jan 1. PMID- 41218388 OWN - NLM STAT- MEDLINE DCOM- 20251130 LR - 20251130 IS - 1873-6807 (Electronic) IS - 1740-1445 (Linking) VI - 55 DP - 2025 Dec TI - Examining the effects of implicit and internalized weight bias on physical activity cognitions for women in larger bodies. PG - 101995 LID - S1740-1445(25)00146-9 [pii] LID - 10.1016/j.bodyim.2025.101995 [doi] AB - Internalized weight bias occurs when negative perceptions about people in larger bodies are attributed to the self. Women in larger bodies frequently experience and internalize weight bias, which can negatively impact physical activity outcomes. Dual process models suggest that information, like experiences of weight stigma, are processed at two levels: associative and propositional. The purpose of this study was to examine whether internalized weight bias measured at the associative and propositional levels was significantly associated with the tendency to avoid physical activity, the expectation of experiencing weight stigma, and self-regulatory efficacy. Participants (n = 154) were over 18, had a BMI over 25, and self-identified as a woman living in a larger body. Implicit weight bias was measured using a single-category implicit association task, while other variables were measured using validated survey measures. Hierarchical multiple regressions were conducted (step 1: covariates; step 2: implicit weight bias [associative]; step 3: internalized weight bias [propositional]). Both implicit (b = -.285, CI: .13,.44) and internalized weight bias (b = -.205, CI: -.37,-.05) were negatively associated with self-regulatory efficacy in step 3. Contrarily, implicit weight bias was significantly associated with the expectation of experiencing weight stigma (b = .203, CI: -.17,.05) and the tendency to avoid physical activity (b = .148, CI: -.18, 07) in step 2, but became non-significant when internalized weight bias was added in step 3 (b = .737, CI: .62,.85; b = .453, CI: .33,.58). Implicit and internalized weight bias were both associated with physical activity related cognitions. Findings provide insight into factors at the associative and propositional level that may dissuade physical activity participation for women in larger bodies. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Jabbar, Jazz AU - Jabbar J AD - Brock University, 1812 Sir Isaac Brock Way, St. Catherines, Ontario L2S 3A1, Canada. Electronic address: jj16lj@brocku.ca. FAU - Ori, Elaine M AU - Ori EM AD - Mount Royal University, 4825 Mount Royal Gate S.W., Calgary, Alberta T3E 6K6, Canada. Electronic address: eori@mtroyal.ca. FAU - Gammage, Kim AU - Gammage K AD - Brock University, 1812 Sir Isaac Brock Way, St. Catherines, Ontario L2S 3A1, Canada. Electronic address: kgammage@brocku.ca. FAU - Dagenais, Matthieu AU - Dagenais M AD - Brock University, 1812 Sir Isaac Brock Way, St. Catherines, Ontario L2S 3A1, Canada. Electronic address: mdagenis@brocku.ca. FAU - Locke, Sean AU - Locke S AD - Brock University, 1812 Sir Isaac Brock Way, St. Catherines, Ontario L2S 3A1, Canada. Electronic address: slocke@brocku.ca. LA - eng PT - Journal Article DEP - 20251110 PL - Netherlands TA - Body Image JT - Body image JID - 101222431 SB - IM MH - Humans MH - Female MH - Adult MH - *Exercise/psychology MH - *Body Image/psychology MH - *Self Concept MH - Young Adult MH - Social Stigma MH - *Weight Prejudice/psychology MH - *Body Weight MH - Middle Aged MH - *Cognition MH - Self Efficacy MH - Adolescent OTO - NOTNLM OT - Appearance OT - Dual process models OT - Evaluation OT - Internalized weight bias OT - Physical activity avoidance OT - Self-efficacy OT - Women in larger bodies COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/11/12 00:26 MHDA- 2025/12/01 00:30 CRDT- 2025/11/11 18:06 PHST- 2025/06/09 00:00 [received] PHST- 2025/10/30 00:00 [revised] PHST- 2025/10/31 00:00 [accepted] PHST- 2025/12/01 00:30 [medline] PHST- 2025/11/12 00:26 [pubmed] PHST- 2025/11/11 18:06 [entrez] AID - S1740-1445(25)00146-9 [pii] AID - 10.1016/j.bodyim.2025.101995 [doi] PST - ppublish SO - Body Image. 2025 Dec;55:101995. doi: 10.1016/j.bodyim.2025.101995. Epub 2025 Nov 10. PMID- 41216266 OWN - NLM STAT- MEDLINE DCOM- 20251113 LR - 20260918 IS - 2046-1402 (Electronic) IS - 2046-1402 (Linking) VI - 14 DP - 2025 TI - Introducing the Multidimensional Toolkit for the Assessment of Play in Schools (M-TAPS): a reliability study. PG - 476 LID - 10.12688/f1000research.160920.2 [doi] LID - 476 AB - BACKGROUND: Despite increasing interest in changing and improving play opportunities in schools, there is lack of openly available methods for evaluating play quantitatively. Existing measures often focus on physical activity during play activities or prioritise the mapping of locations within which play occurs rather than evaluating play itself. METHODS: This paper introduces the Multidimensional Toolkit for the Assessment of Play in Schools (M-TAPS) and provides the results of an initial study examining the utility and reliability of the toolkit. The M-TAPS includes observations of individual children and scan observations of predefined areas of the playground; children's activities, adventure/risk level and affect are coded. In addition, the M-TAPS includes child self-report questionnaires about emotions during playtime and playtime activities. RESULTS: The reliability study provided evidence of good reliability between coders and for children's self-report of their emotions during playtime. There was some indication of validity between child self-report and coder observation. CONCLUSIONS: The paper suggests that the M-TAPS may be useful for research focused on improving children's play in schools where a quantitative measure is sought. The M-TAPS provides a flexible tool for supporting researchers with the results highlighting how the M-TAPS can provide insights into schools playtimes and how observation can be combined with children's self-report. There is room for further development and refinement of the toolkit. CI - Copyright: (c) 2025 Dodd H et al. FAU - Dodd, Helen AU - Dodd H AUID- ORCID: 0000-0003-1446-5338 AD - School of Psychology and Clinical Language Sciences, University of Reading, Reading, England, UK. AD - Public Health and Sport Sciences, University of Exeter, Exeter, England, UK. FAU - Nesbit, Rachel AU - Nesbit R AUID- ORCID: 0000-0001-7540-3187 AD - School of Psychology and Clinical Language Sciences, University of Reading, Reading, England, UK. FAU - FitzGibbon, Lily AU - FitzGibbon L AD - School of Psychology and Clinical Language Sciences, University of Reading, Reading, England, UK. AD - Division of Psychology, University of Stirling, Stirling, Scotland, UK. LA - eng PT - Journal Article DEP - 20251020 PL - England TA - F1000Res JT - F1000Research JID - 101594320 SB - IM MH - Humans MH - *Schools MH - *Play and Playthings MH - Child MH - Reproducibility of Results MH - Male MH - Surveys and Questionnaires MH - Female MH - Self Report MH - Emotions PMC - PMC12596566 OTO - NOTNLM OT - play; playtime; recess; measure; observation; child COIS- No competing interests were disclosed. EDAT- 2025/11/11 06:31 MHDA- 2025/11/13 06:30 PMCR- 2025/10/20 CRDT- 2025/11/11 04:28 PHST- 2025/10/16 00:00 [accepted] PHST- 2025/11/13 06:30 [medline] PHST- 2025/11/11 06:31 [pubmed] PHST- 2025/11/11 04:28 [entrez] PHST- 2025/10/20 00:00 [pmc-release] AID - 10.12688/f1000research.160920.2 [doi] PST - epublish SO - F1000Res. 2025 Oct 20;14:476. doi: 10.12688/f1000research.160920.2. eCollection 2025. PMID- 41214819 OWN - NLM STAT- MEDLINE DCOM- 20251113 LR - 20251113 IS - 2047-783X (Electronic) IS - 0949-2321 (Print) IS - 0949-2321 (Linking) VI - 30 IP - 1 DP - 2025 Nov 10 TI - S-shaped association between hs-CRP/HDL-C index and overweight/obesity in children and adolescents: a population-based study. PG - 1102 LID - 10.1186/s40001-025-03368-8 [doi] LID - 1102 AB - BACKGROUND: Obesity has become a growing public health problem worldwide, especially in children and adolescents. The ultrasensitive C-reactive protein (hs-CRP)/high-density lipoprotein cholesterol (HDL-C) index is a widely recognized marker of metabolic disorders and inflammatory responses. However, its connection to overweight or obesity in children and adolescents remains unclear. This study aimed to examine the association between the hs-CRP/HDL-C index and overweight or obesity, to identify its possible threshold effect, and to offer a new theoretical basis for prevention and control among youth. METHODS: This study investigated the relationship between hs-CRP/HDL-C index and overweight and obesity in children and adolescents aged 6-19 years, utilizing data from the 2015-2020 National Health and Nutrition Examination Survey (NHANES). This analysis employed t tests, Chi-square tests, multiple logistic regression, restricted cubic spline regression (RCS), and piecewise regression methods to validate the association between the hs-CRP/HDL-C index and overweight/obesity, and to explore potential nonlinear patterns and key thresholds between the two. RESULTS: This study included 3853 children and adolescents. Multivariate logistic regression analysis revealed a significant positive relationship between the log-transformed indicator and overweight/obesity (OR = 5.81; 95% CI 5.02-6.75; P < 0.001). Furthermore, smoothed curve fitting revealed a nonlinear S-shaped dose-response relationship between the two variables. In addition, segmented regression analysis of hs-CRP/HDL-C identified two inflection points (0.653 and 1.593). Notably, except for household income, interaction p values across subgroups were all greater than 0.05, indicating high stability and consistency among subgroups. However, household income exerted a significant modifying effect. CONCLUSION: This study finds that the hs-CRP/HDL-C index is associated with overweight and obesity in children and adolescents in a manner that is not linear. There is a critical range (0.653-1.593) where higher values of the index are related to lower rates of overweight and obesity. Based on these results, it is recommended that pediatric healthcare providers use hs-CRP/HDL-C testing routinely, which may help identify children at risk and support early obesity prevention. Future studies should confirm these findings in additional groups and develop more effective interventions. CI - (c) 2025. The Author(s). FAU - Cui, Zhengjiu AU - Cui Z AD - Department of Pediatrics, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. FAU - Zhu, Zhiyao AU - Zhu Z AD - Department of Pediatrics, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. FAU - Shao, Jiayi AU - Shao J AD - Department of Pediatrics, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. FAU - Zhang, Sha AU - Zhang S AD - Department of Pediatrics, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. FAU - Wang, Yuanyuan AU - Wang Y AD - Department of Pediatrics, Suqian Affiliated Hospital of Nanjing University of Chinese Medicine, Suqian, China. FAU - Jiang, Mingchen AU - Jiang M AD - Department of Pediatrics, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. jmc@njucm.edu.cn. FAU - Yuan, Bin AU - Yuan B AD - Department of Pediatrics, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. yfy0045@njucm.edu.cn. LA - eng PT - Journal Article DEP - 20251110 PL - England TA - Eur J Med Res JT - European journal of medical research JID - 9517857 RN - 9007-41-4 (C-Reactive Protein) RN - 0 (Cholesterol, HDL) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Adolescent MH - Child MH - *C-Reactive Protein/metabolism/analysis MH - Male MH - Female MH - Nutrition Surveys MH - *Cholesterol, HDL/blood MH - *Pediatric Obesity/blood/epidemiology MH - Young Adult MH - *Overweight/blood/epidemiology MH - Biomarkers/blood MH - Cross-Sectional Studies PMC - PMC12604413 OTO - NOTNLM OT - Adolescents OT - Children OT - Cross-sectional study OT - Hs-CRP/HDL-C index OT - Overweight/Obesity COIS- Declarations. Ethics approval and consent to participate: All participants provided written informed consent and study procedures were approved by the National Center for Health Statistics Research Ethics Review Board. Competing interest: The authors declare no competing interests. EDAT- 2025/11/11 06:31 MHDA- 2025/11/13 06:30 PMCR- 2025/11/10 CRDT- 2025/11/11 00:24 PHST- 2025/05/09 00:00 [received] PHST- 2025/10/15 00:00 [accepted] PHST- 2025/11/13 06:30 [medline] PHST- 2025/11/11 06:31 [pubmed] PHST- 2025/11/11 00:24 [entrez] PHST- 2025/11/10 00:00 [pmc-release] AID - 10.1186/s40001-025-03368-8 [pii] AID - 3368 [pii] AID - 10.1186/s40001-025-03368-8 [doi] PST - epublish SO - Eur J Med Res. 2025 Nov 10;30(1):1102. doi: 10.1186/s40001-025-03368-8. PMID- 41214604 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Nov 10 TI - Association between screen exposure and language development delay during the COVID-19 pandemic for 18-72 months children in China: evidence from a cross-sectional study. PG - 3889 LID - 10.1186/s12889-025-25050-8 [doi] LID - 3889 AB - BACKGROUND: The impact of screen exposure on children's language development has been widely debated. However, some characteristics of screen use, particularly the influence of the pandemic over the past three years have yet to be sufficiently investigated. OBJECTIVES: To examine the association between screen exposure, particularly during the pandemic, and language development delays in children aged 18-72 months. METHODS: A total of 2100 children who attended the children's language development clinic at Guangzhou Women and Children's Medical Center and Yuncheng Street Community Health Service Center in Guangzhou, China, were recruited into the study between January 2020 and September 2023. Children's demographic and developmental characteristics were obtained through a structured questionnaire, and their language development delays were evaluated through the Sign-Significate Relations (S-S) assessment, which was subsequently validated by the China Developmental Scale for Children method based on the voluntary principle. Multivariate logistic regression models were employed to analyze the association between screen exposure and language development delay. In order to gain further insight, the data was stratified according to whether or not the children had experienced a period of social isolation due to the COVID-19 pandemic, the parenting environment and the quality of screen usage. RESULTS: More than half of the children (53.29%) were exposed to screens for over 1 h daily. After adjusting for potential confounders, a dose-response relationship was observed between children's daily screen exposure exceeding 1 h and the risk of delayed language development. The stratified analyses confirmed the main findings, revealing stronger associations in children who had experienced at least one period of quarantine, whose primary language spoken at home was Cantonese, whose caregivers had an intermediate personality, whose daily outdoor activities were less than 2 h, who did not have interaction with caregivers during screen time, and who watched educational videos. CONCLUSION: This study suggested that excessive screen exposure in children was associated with a heightened likelihood of language development delays, especially among children who experienced COVID-19 quarantine with prolonged screen time. FAU - Liu, Huiyan AU - Liu H AD - Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, Guangdong, China. FAU - Yi, Shiting AU - Yi S AD - First School of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong, China. FAU - Li, Yanwen AU - Li Y AD - First School of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong, China. FAU - Sun, Jing AU - Sun J AD - Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, Guangdong, China. FAU - Xiao, Wanqi AU - Xiao W AD - Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, Guangdong, China. FAU - Bai, Yan AU - Bai Y AD - First School of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong, China. angell_bai@163.com. FAU - Chen, Yingjun AU - Chen Y AD - First School of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong, China. chenyingjun@gdpu.edu.cn. LA - eng GR - SL2023A04J0215/Guangzhou Basic and Applied Basic Research Scheme/ PT - Journal Article DEP - 20251110 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - *COVID-19/epidemiology MH - China/epidemiology MH - Female MH - Cross-Sectional Studies MH - Child, Preschool MH - *Screen Time MH - Infant MH - *Language Development Disorders/epidemiology MH - Media Exposure MH - Male MH - Pandemics MH - Child MH - SARS-CoV-2 PMC - PMC12604418 OTO - NOTNLM OT - COVID-19 OT - Children OT - Language development OT - Public health OT - Screen exposure COIS- Declarations. Ethics approval and consent to participate: All procedures involving human subjects have been approved by the Ethics Committee of Guangzhou Women and Children's Medical Center (2017053002). All methods were carried out in accordance with relevant guidelines and regulations. Participants in the survey were voluntary, and informed consent was obtained from all subjects in the survey questionnaire. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/11 06:31 MHDA- 2026/06/27 00:57 PMCR- 2025/11/10 CRDT- 2025/11/11 00:16 PHST- 2024/05/10 00:00 [received] PHST- 2025/09/23 00:00 [accepted] PHST- 2026/06/27 00:57 [medline] PHST- 2025/11/11 06:31 [pubmed] PHST- 2025/11/11 00:16 [entrez] PHST- 2025/11/10 00:00 [pmc-release] AID - 10.1186/s12889-025-25050-8 [pii] AID - 25050 [pii] AID - 10.1186/s12889-025-25050-8 [doi] PST - epublish SO - BMC Public Health. 2025 Nov 10;25(1):3889. doi: 10.1186/s12889-025-25050-8. PMID- 41214436 OWN - NLM STAT- MEDLINE DCOM- 20251224 LR - 20260701 IS - 1749-6632 (Electronic) IS - 0077-8923 (Print) IS - 0077-8923 (Linking) VI - 1554 IP - 1 DP - 2025 Dec TI - Digital Data Donation With Adolescents. PG - 251-266 LID - 10.1111/nyas.70140 [doi] AB - Growing concerns about digital media's impact on adolescent well-being highlight critical limitations in existing research methodologies that rely predominantly on self-reported screen time measures, which inadequately capture the complexity of digital interactions and behavioral patterns. Data donation, where individuals voluntarily share objective social media data, offers a transformative approach, yet its feasibility with adolescents remains underexplored. This study evaluated the feasibility of implementing data donation methodology with adolescent populations to develop practical guidelines for future studies. We conducted a large-scale, 2-week longitudinal trial (N = 358, aged 13-18) alongside focus groups and youth advisory panels, integrating ecological momentary assessment (EMA), validated psychometrics, and data donation from Instagram and TikTok. Results demonstrated strong feasibility across technical, ethical, and engagement dimensions: Overall, 78.9% of participants donated Instagram data, and 65.8% donated TikTok data, with 74% average EMA response rates. Findings indicate substantial willingness to participate in intensive digital behavioral research when appropriate safeguards and youth-centered approaches are implemented. We propose six key recommendations for data donation studies with adolescents: (1) clearly communicating research value, (2) establishing rigorous consent procedures, (3) centering adolescents' voices through co‑design, (4) selecting appropriate platforms, (5) implementing suitable technical frameworks, and (6) building robust multi‑stakeholder recruitment strategies. CI - (c) 2025 The Author(s). Annals of the New York Academy of Sciences published by Wiley Periodicals LLC on behalf of The New York Academy of Sciences. FAU - Yap, Valerie Z Y AU - Yap VZY AD - Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom. FAU - Skeggs, Amira AU - Skeggs A AD - Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom. FAU - Ferguson, Amanda M AU - Ferguson AM AD - Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom. FAU - Leyland-Craggs, Amelia AU - Leyland-Craggs A AD - Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom. FAU - Boeschoten, Laura AU - Boeschoten L AD - Department of Methodology and Statistics, Utrecht University, Utrecht, the Netherlands. FAU - Welbers, Kasper AU - Welbers K AD - Department of Communication Science, Vrije Universiteit Amsterdam, Amsterdam, Netherlands. FAU - Kurten, Sebastian AU - Kurten S AD - Department of Interdisciplinary Social Science, Utrecht University, Utrecht, Netherlands. FAU - Orben, Amy AU - Orben A AD - Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom. LA - eng GR - Cambridge Trust Cambridge Australia Poynton PhD Scholarship/ GR - Jacobs Foundation/ GR - MR/X034925/1/UK Research and Innovation Future Leader's Fellowship/ GR - MC_UU_0030/13/MRC_/Medical Research Council/United Kingdom GR - MR/X028801/1/MRC_/Medical Research Council/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251110 PL - United States TA - Ann N Y Acad Sci JT - Annals of the New York Academy of Sciences JID - 7506858 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - *Social Media MH - Longitudinal Studies MH - *Adolescent Behavior/psychology MH - Focus Groups MH - Ecological Momentary Assessment PMC - PMC12728328 OTO - NOTNLM OT - adolescents OT - data collection OT - data donation OT - data infrastructure OT - digital media OT - social media COIS- In the past 36 months, A.O. has received funding from the Jacobs Foundation, UK Research and Innovation (incl. the Medical Research Council, the Economic and Social Research Council, and the Engineering and Physical Sciences Research Council), the UK Department for Science, Innovation and Technology, the National Institute of Health, the University of Cambridge, Emmanuel College of the University of Cambridge, and the Livelihood Impact Fund. She was an unpaid member of the ESRC Smart Data Research UK Programme Board, British Academy Public Policy Committee, UK Department for Education Science Advisory Council, UK Department for Science, Innovation and Technology and UK Department for Culture, Media and Sport College of Experts, Australian eSafety Commissioner Social Media Minimum Age Evaluation Academic Advisory Group, and a paid member of the Digital Futures for Children Centre Advisory Board. She has received payment for lectures from SWGfL and Apple University; she also received consulting fees from Innovate UK through Opalescent LTD. EDAT- 2025/11/11 00:27 MHDA- 2025/12/24 07:43 PMCR- 2025/12/24 CRDT- 2025/11/10 23:43 PHST- 2025/12/24 07:43 [medline] PHST- 2025/11/11 00:27 [pubmed] PHST- 2025/11/10 23:43 [entrez] PHST- 2025/12/24 00:00 [pmc-release] AID - NYAS70140 [pii] AID - 10.1111/nyas.70140 [doi] PST - ppublish SO - Ann N Y Acad Sci. 2025 Dec;1554(1):251-266. doi: 10.1111/nyas.70140. Epub 2025 Nov 10. PMID- 41214410 OWN - NLM STAT- MEDLINE DCOM- 20251112 LR - 20260925 IS - 2162-4968 (Electronic) IS - 2162-4968 (Linking) VI - 14 IP - 1 DP - 2025 Nov 11 TI - Graze Eating and Obesity: A Conceptualization Within the Spectrum of Disordered Eating. PG - 79 LID - 10.1007/s13679-025-00666-4 [doi] AB - PURPOSE OF REVIEW: This review examines recent literature on grazing and its two subtypes - compulsive (CG) and non-compulsive (NCG) - utilizing a consistent definition and psychometrically sound instruments. RECENT FINDINGS: Grazing is a distinct problematic eating behavior, prevalent across various weight, age, and sexes groups, with higher rates observed in younger adults and older children/adolescents. Grazing has associations with socioeconomic status, and scores differ between countries, suggesting cultural differences. Grazing is consistently linked to higher body mass index, poor weight loss and metabolic control outcomes after metabolic-bariatric surgery. CG, particularly, has been consistently associated with greater psychological distress, eating disorder psychopathology, affective dysregulation, impulsivity and addictive behaviors, and poorer quality of life. Grazing is a problematic eating behavior associated with loss of control eating, and within the spectrum of disordered eating. Assessing and addressing grazing may be a crucial strategy to mitigate obesity and its associated medical risks. CI - (c) 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Conceicao, Eva AU - Conceicao E AUID- ORCID: 0000-0002-1982-5796 AD - Faculty of Psychology and Education Sciences, Center for Psychology, University of Porto, Rua Alfredo Allen, s/n, Porto, 4200-135, Portugal. econceicao@fpce.up.pt. FAU - Heriseanu, Andreea AU - Heriseanu A AUID- ORCID: 0000-0002-0325-9005 AD - eCentreClinic, School of Psychological Sciences, Macquarie University, Wallumattagal Campus, Macquarie Park, Sydney, NSW, 2109, Australia. FAU - Goldschmidt, Andrea B AU - Goldschmidt AB AUID- ORCID: 0000-0003-1620-8300 AD - Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. LA - eng GR - R01 DK136540/DK/NIDDK NIH HHS/United States GR - R01 HL147914/HL/NHLBI NIH HHS/United States GR - R01-DK136540/National Institute of Diabetes and Digestive and Kidney Diseases, United States/ GR - UIDB/00050/2020/Fundacao para a Ciencia e a Tecnologia/ GR - R01 DK120597/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Review DEP - 20251111 PL - United States TA - Curr Obes Rep JT - Current obesity reports JID - 101578283 SB - IM MH - Humans MH - *Feeding and Eating Disorders/psychology MH - *Obesity/psychology MH - *Feeding Behavior/psychology MH - Quality of Life MH - Body Mass Index MH - Female MH - *Compulsive Behavior/psychology MH - Adult MH - Male PMC - PMC12638020 MID - NIHMS2119362 OTO - NOTNLM OT - Compulsive Eating OT - Eating Disorders OT - Grazing OT - Loss of Control Eating OT - Obesity OT - Problematic Eating Behaviors COIS- Declarations. Competing Interests: The authors declare no competing interests. EDAT- 2025/11/11 00:27 MHDA- 2025/11/13 00:31 PMCR- 2025/11/21 CRDT- 2025/11/10 23:42 PHST- 2025/03/04 00:00 [received] PHST- 2025/10/01 00:00 [accepted] PHST- 2025/11/13 00:31 [medline] PHST- 2025/11/11 00:27 [pubmed] PHST- 2025/11/10 23:42 [entrez] PHST- 2025/11/21 00:00 [pmc-release] AID - 10.1007/s13679-025-00666-4 [pii] AID - 10.1007/s13679-025-00666-4 [doi] PST - epublish SO - Curr Obes Rep. 2025 Nov 11;14(1):79. doi: 10.1007/s13679-025-00666-4. PMID- 41212804 OWN - NLM STAT- MEDLINE DCOM- 20260413 LR - 20260602 IS - 1421-9697 (Electronic) IS - 0250-6807 (Linking) VI - 82 IP - 2 DP - 2026 TI - Association between Total Fruit Consumption and Risk of Gestational Diabetes Mellitus: The Japan Environment and Children's Study. PG - 81-89 LID - 10.1159/000549407 [doi] AB - INTRODUCTION: Whether the consumption of fruits, flavonoid-rich fruits, and 100% fruit juice is associated with the risk of gestational diabetes mellitus (GDM) is unclear. We aimed to examine the association of total fruit, flavonoid-rich fruits, and 100% fruit juice consumption with the risk of GDM. METHODS: A total of 93,759 singleton pregnancies who were enrolled in the Japan Environment and Children's Study remained for the analysis. Total fruit consumption including fruits and 100% fruit juice during the past year in the first trimester was assessed using a validated food frequency questionnaire (FFQ). Odds ratios (ORs) and 95% confidence intervals (CIs) for GDM associated with total fruit, flavonoid-rich fruits, non-flavonoid-rich fruits, and 100% fruit juice consumption were estimated using logistic regression analysis. RESULTS: GDM occurred in 2,096 (2.2%) of the 93,759 pregnant women. Total fruit consumption was inversely associated with the risk of GDM; the multivariable ORs (95% CI) for the highest vs. lowest quartiles of total fruit consumption were 0.82 (0.71, 0.95) (p for trend = 0.013). An increase in total fruit consumption by each 100 g/day was inversely associated with the risk of GDM (OR = 0.94 [0.91, 0.98], p for trend = 0.001). The multivariable ORs (95% CIs) for the highest versus lowest quartiles of flavonoid-rich fruits consumption was 0.80 (0.70, 0.93) (p for trend = 0.003), whereas that for non-flavonoid-rich fruits consumption was 0.96 (0.83, 1.11) (p for trend = 0.504); 100% fruit juice consumption was inversely associated with the risk of GDM for each 100 mL/day increase (OR = 0.91, 95% CI: 0.87, 0.96). CONCLUSION: Total fruit, flavonoid-rich fruits, and 100% fruit juice consumption were inversely associated with risk of GDM. CI - (c) 2025 S. Karger AG, Basel. FAU - Kojima, Akane AU - Kojima A AD - Osaka Regional Center for Japan Environment and Children's Study (JECS), The University of Osaka, Osaka, Japan. AD - Department of Nutrition, Faculty of Health and Nutrition, Yamanashi Gakuin University, Yamanashi, Japan. FAU - Ikehara, Satoyo AU - Ikehara S AD - Osaka Regional Center for Japan Environment and Children's Study (JECS), The University of Osaka, Osaka, Japan, s-ike@cs.u-ryukyu.ac.jp. AD - Department of Epidemiology and Behavioral Science, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan, s-ike@cs.u-ryukyu.ac.jp. FAU - Miyazaki, Junji AU - Miyazaki J AD - Osaka Regional Center for Japan Environment and Children's Study (JECS), The University of Osaka, Osaka, Japan. AD - Public Health, Department of Social and Environmental Medicine, Graduate School of Medicine, The University of Osaka, Osaka, Japan. FAU - Kawasaki, Ryo AU - Kawasaki R AD - Osaka Regional Center for Japan Environment and Children's Study (JECS), The University of Osaka, Osaka, Japan. AD - Public Health, Department of Social and Environmental Medicine, Graduate School of Medicine, The University of Osaka, Osaka, Japan. FAU - Iso, Hiroyasu AU - Iso H AD - Osaka Regional Center for Japan Environment and Children's Study (JECS), The University of Osaka, Osaka, Japan. AD - Institute for Global Health Policy Research, Bureau of International Health Cooperation, National Center for Global Health and Medicine, Tokyo, Japan. LA - eng PT - Journal Article DEP - 20251110 PL - Switzerland TA - Ann Nutr Metab JT - Annals of nutrition & metabolism JID - 8105511 RN - 0 (Flavonoids) SB - IM MH - Humans MH - Female MH - *Diabetes, Gestational/epidemiology/prevention & control MH - Pregnancy MH - *Fruit MH - Japan/epidemiology MH - Adult MH - *Diet MH - Fruit and Vegetable Juices MH - Risk Factors MH - Flavonoids/administration & dosage MH - Odds Ratio MH - Surveys and Questionnaires MH - Logistic Models OTO - NOTNLM OT - Flavonoid-rich fruits consumption OT - Flavonoids OT - Food frequency questionnaire OT - Gestational diabetes mellitus OT - Total fruit consumption EDAT- 2025/11/10 18:23 MHDA- 2026/04/13 18:31 CRDT- 2025/11/10 13:23 PHST- 2025/05/20 00:00 [received] PHST- 2025/11/02 00:00 [accepted] PHST- 2026/04/13 18:31 [medline] PHST- 2025/11/10 18:23 [pubmed] PHST- 2025/11/10 13:23 [entrez] AID - 000549407 [pii] AID - 10.1159/000549407 [doi] PST - ppublish SO - Ann Nutr Metab. 2026;82(2):81-89. doi: 10.1159/000549407. Epub 2025 Nov 10. PMID- 41212194 OWN - NLM STAT- MEDLINE DCOM- 20260416 LR - 20261010 IS - 1433-3023 (Electronic) IS - 0937-3462 (Linking) VI - 37 IP - 4 DP - 2026 Apr TI - Childhood Stress Urinary Incontinence in High-Impact Gymnasts: Does it Affect Their Future Risk of Adult Stress Urinary Incontinence? PG - 957-961 LID - 10.1007/s00192-025-06330-8 [doi] AB - INTRODUCTION AND HYPOTHESIS: Stress urinary incontinence (SUI) is common among high-impact athletes and can be experienced with high-impact activity during childhood. We sought to identify whether leakage experienced during gymnastics training before age 18 impacts future SUI. METHODS: An observational cohort study was performed. Current and former competitive gymnasts 18 years or older were queried by a survey disseminated via Facebook starting 1 September through November 2024. The survey was composed of a nonvalidated portion that inquired regarding the conditions under which participants experienced incontinence before and after age 18. The validated Urogenital Distress Inventory (UDI-6) assessed current voiding symptoms. Chi-squared evaluated significance between childhood and adult SUI. Univariate and multivariate linear regression identified patient characteristics associated with increasing UDI-6 scores. RESULTS: A total of 146 people responded to the survey, with 126 complete responses. Participants ranged from 18 to 65 years of age. Among the 64 (50.8%) who experienced SUI with gymnastics under 18 years, 54 (84.4%) experienced SUI as adults. In contrast, 32 (51.6%) of participants who did not experience SUI under 18 years experienced SUI as adults (p < 0.001). Multivariate analysis revealed that SUI with gymnastics training under age 18 was associated with increasing weighted UDI-6 scaled score (p < 0.04), particularly in the stress domain (p < 0.001). BMI was also associated with increasing UDI-6 scaled score (p = 0.02). CONCLUSIONS: High-impact athletes who experience SUI with training under age 18 are more likely to experience SUI as adults. Earlier recognition of SUI during high-impact activities could ultimately improve patients' long-term quality of life. CI - (c) 2025. The Author(s), under exclusive license to International Urogynecological Association. FAU - Buford, Karis AU - Buford K AUID- ORCID: 0000-0001-8281-8209 AD - Corewell Health William Beaumont University Hospital, 3535 W 13 Mild Rd. Ste 438,, Royal Oak, MI, 48073, USA. karisbuford@gmail.com. FAU - Grajeda, Samuel AU - Grajeda S AD - Oakland University William Beaumont School of Medicine, Rochester, MI, USA. FAU - Zwaans, Bernadette M M AU - Zwaans BMM AD - Corewell Health William Beaumont University Hospital, 3535 W 13 Mild Rd. Ste 438,, Royal Oak, MI, 48073, USA. AD - Oakland University William Beaumont School of Medicine, Rochester, MI, USA. FAU - Padmanabhan, Priya AU - Padmanabhan P AD - Corewell Health William Beaumont University Hospital, 3535 W 13 Mild Rd. Ste 438,, Royal Oak, MI, 48073, USA. AD - Oakland University William Beaumont School of Medicine, Rochester, MI, USA. LA - eng PT - Journal Article PT - Observational Study DEP - 20251110 PL - England TA - Int Urogynecol J JT - International urogynecology journal JID - 101567041 SB - IM MH - Humans MH - Female MH - *Urinary Incontinence, Stress/epidemiology/etiology MH - *Gymnastics MH - Adult MH - Adolescent MH - Middle Aged MH - Young Adult MH - Aged MH - Cohort Studies MH - Risk Factors MH - Surveys and Questionnaires MH - *Athletes/statistics & numerical data MH - Male OTO - NOTNLM OT - Adulthood OT - Childhood OT - High-impact gymnastics OT - Stress incontinence OT - Stress urinary incontinence OT - Women COIS- Declarations. Ethical/Institutional Review Board Approval: This study was reviewed and granted approval (IRB 2023-285) via Corewell Health William Beaumont University Hospital in Royal Oak, MI, USA. Conflicts of Interest: None. EDAT- 2025/11/10 12:35 MHDA- 2026/04/19 17:38 CRDT- 2025/11/10 11:13 PHST- 2025/05/28 00:00 [received] PHST- 2025/08/24 00:00 [accepted] PHST- 2026/04/19 17:38 [medline] PHST- 2025/11/10 12:35 [pubmed] PHST- 2025/11/10 11:13 [entrez] AID - 10.1007/s00192-025-06330-8 [pii] AID - 10.1007/s00192-025-06330-8 [doi] PST - ppublish SO - Int Urogynecol J. 2026 Apr;37(4):957-961. doi: 10.1007/s00192-025-06330-8. Epub 2025 Nov 10. PMID- 41211208 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251112 LR - 20251112 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - The associations of diet quality and cardiometabolic indicators in children and the mediation role of cardiorespiratory fitness. PG - 1632493 LID - 10.3389/fnut.2025.1632493 [doi] LID - 1632493 AB - BACKGROUND: Cardiometabolic health in children has become a growing global concern due to its long-term association with chronic diseases such as cardiovascular disease and type 2 diabetes. Diet quality plays a critical role in determining cardiometabolic health. This study explored the association between diet quality and cardiometabolic health indicators in Chinese children aged 8-10 years and assessed the mediating role of cardiorespiratory fitness (CRF). METHODS: A total of 1,389 third-grade students from Ningbo, China were included. Diet quality was assessed using a validated questionnaire to calculate a Global Dietary Recommendations (GDR) score, with higher scores indicating healthier dietary patterns. Anthropometric data and fasting blood samples were collected to evaluate metabolic markers. A cardiometabolic risk (CMR) score was calculated based on age- and sex-adjusted Z-scores for waist circumference, systolic blood pressure, triglycerides, total cholesterol to high-density lipoprotein cholesterol ratio, and homeostasis model assessment for insulin resistance (HOMA-IR). CRF was measured using the 20-meter shuttle run test. Generalized linear mixed models were used to examine associations, and mediation analysis was conducted to assess the mediating effect of CRF. RESULTS: After adjusting for age, sex, and physical activity, higher GDR scores were significantly associated with lower fasting insulin (beta = -0.013; p = 0.023), lower HOMA-IR (beta = -0.014; p = 0.019), and reduced CMR score (beta = -0.074; p = 0.030). Stratified and interaction analyses revealed stronger associations in girls than in boys. Mediation analysis showed that CRF accounted for 26.1% of the association between GDR score and fasting insulin, 25.3% for HOMA-IR, and 32.9% for CMR score (all p < 0.05). CONCLUSION: In Chinese children, better diet quality is associated with more favorable cardiometabolic profiles. CRF showed a statistically significant mediating role in the cross-sectional association, highlighting the potential importance of both healthy eating and physical fitness in promoting cardiometabolic health in youth. CI - Copyright (c) 2025 Zhang, Lin, Gu, Wang, Zhang, Zhou, Xu, Wang and Li. FAU - Zhang, Ping-Ping AU - Zhang PP AD - Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China. AD - Ningbo Center for Healthy Lifestyle Research, Chronic Disease Management Office, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China. FAU - Lin, Gao-Feng AU - Lin GF AD - Fuming Street Community Health Service Center of Yinzhou District, Ningbo, Zhejiang, China. FAU - Gu, Jia-Ying AU - Gu JY AD - Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China. AD - Ningbo Center for Healthy Lifestyle Research, Chronic Disease Management Office, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China. FAU - Wang, Bi-Lian AU - Wang BL AD - School Medical Office, Ningbo Art Experimental School, Ningbo, Zhejiang, China. FAU - Zhang, Jie AU - Zhang J AD - Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China. AD - Health Science Center, Ningbo University, Ningbo, Zhejiang, China. FAU - Zhou, Ye AU - Zhou Y AD - Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China. FAU - Xu, Miao AU - Xu M AD - Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China. FAU - Wang, Hui AU - Wang H AD - Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, China. FAU - Li, Li AU - Li L AD - Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China. LA - eng PT - Journal Article DEP - 20251023 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12588837 OTO - NOTNLM OT - cardiometabolic risk OT - cardiorespiratory fitness OT - children OT - diet quality OT - mediation effect COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/11/10 18:16 MHDA- 2025/11/10 18:17 PMCR- 2025/10/23 CRDT- 2025/11/10 06:15 PHST- 2025/05/21 00:00 [received] PHST- 2025/10/07 00:00 [accepted] PHST- 2025/11/10 18:17 [medline] PHST- 2025/11/10 18:16 [pubmed] PHST- 2025/11/10 06:15 [entrez] PHST- 2025/10/23 00:00 [pmc-release] AID - 10.3389/fnut.2025.1632493 [doi] PST - epublish SO - Front Nutr. 2025 Oct 23;12:1632493. doi: 10.3389/fnut.2025.1632493. eCollection 2025. PMID- 41210113 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251112 LR - 20251112 IS - 2251-6581 (Print) IS - 2251-6581 (Electronic) IS - 2251-6581 (Linking) VI - 24 IP - 2 DP - 2025 Dec TI - Association between the dietary inflammatory index and spexin levels, metabolic syndrome, and inflammatory biomarkers in children with obesity. PG - 262 LID - 10.1007/s40200-025-01782-7 [doi] LID - 262 AB - BACKGROUND: Chronic low-grade diet-related inflammation has been indicated to affect obesity and metabolic syndrome (MetS). The current study was designed to explore the Dietary Inflammatory Index (DII) in children and its relationship with spexin levels, appetite, and various cardiometabolic factors, including MetS, obesity, insulin resistance, and specific inflammatory biomarkers. METHODS: This study included 90 obese adolescents and 90 normal-weight adolescents for overall analysis. A subset of 90 participants (45 obese and 45 normal-weight) provided blood samples for biochemical assays. Dietary intake was assessed using a validated 168-item semi-quantitative food frequency questionnaire, from which the DII score was calculated. Multivariable logistic regression models were employed to evaluate the association between the DII score and cardiometabolic risk factors. RESULTS: The children's mean DII score was - 1.25 (+/- 1.01). Higher DII scores (indicating a more pro-inflammatory diet) were significantly associated with increased odds of obesity across all adjusted models (OR: 2.03, 95% CI: 1.10-3.75). A significant positive correlation was found between DII scores and high-sensitivity C-reactive protein levels (r = 0.30, P = 0.005). In crude analysis, the most anti-inflammatory diet was associated with higher spexin and interleukin-10 levels and a lower appetite score; however, these associations were no longer significant after adjustment for confounders. No significant associations were found between DII and metabolic syndrome or its components. CONCLUSION: These findings indicate that the influence of the DII on obesity may be primarily mediated through spexin levels, inflammatory markers, and appetite regulation, rather than through direct effects on MetS components. CI - (c) The Author(s), under exclusive licence to Tehran University of Medical Sciences 2025. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. FAU - Behrooz, Maryam AU - Behrooz M AD - Nutrition Research Center, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. ROR: https://ror.org/04krpx645. GRID: grid.412888.f. ISNI: 0000 0001 2174 8913 AD - Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. ROR: https://ror.org/04krpx645. GRID: grid.412888.f. ISNI: 0000 0001 2174 8913 FAU - Hajjarzadeh, Samaneh AU - Hajjarzadeh S AD - Nutrition and Metabolic Diseases Research Center, Clinical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. ROR: https://ror.org/01rws6r75. GRID: grid.411230.5. ISNI: 0000 0000 9296 6873 AD - Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. ROR: https://ror.org/01rws6r75. GRID: grid.411230.5. ISNI: 0000 0000 9296 6873 AD - Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. ROR: https://ror.org/01rws6r75. GRID: grid.411230.5. ISNI: 0000 0000 9296 6873 FAU - Moludi, Jalal AU - Moludi J AD - School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran. ROR: https://ror.org/05vspf741. GRID: grid.412112.5. ISNI: 0000 0001 2012 5829 FAU - Bakhshimoghaddam, Farnush AU - Bakhshimoghaddam F AD - Nutrition and Metabolic Diseases Research Center, Clinical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. ROR: https://ror.org/01rws6r75. GRID: grid.411230.5. ISNI: 0000 0000 9296 6873 AD - Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. ROR: https://ror.org/01rws6r75. GRID: grid.411230.5. ISNI: 0000 0000 9296 6873 FAU - Ostadrahimi, Alireza AU - Ostadrahimi A AD - Nutrition Sciences, Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Attar Neyshabouri Av., Golgasht St, Tabriz, Iran. ROR: https://ror.org/04krpx645. GRID: grid.412888.f. ISNI: 0000 0001 2174 8913 LA - eng PT - Journal Article DEP - 20251107 PL - Switzerland TA - J Diabetes Metab Disord JT - Journal of diabetes and metabolic disorders JID - 101590741 PMC - PMC12594623 OTO - NOTNLM OT - Dietary inflammatory index OT - Insulin resistance OT - Metabolic syndrome OT - Obesity OT - Spexin COIS- Competing interestsThe authors declare no competing interests. EDAT- 2025/11/10 18:16 MHDA- 2025/11/10 18:17 PMCR- 2026/11/07 CRDT- 2025/11/10 06:05 PHST- 2025/05/05 00:00 [received] PHST- 2025/10/27 00:00 [accepted] PHST- 2025/11/10 18:17 [medline] PHST- 2025/11/10 18:16 [pubmed] PHST- 2025/11/10 06:05 [entrez] PHST- 2026/11/07 00:00 [pmc-release] AID - 1782 [pii] AID - 10.1007/s40200-025-01782-7 [doi] PST - epublish SO - J Diabetes Metab Disord. 2025 Nov 7;24(2):262. doi: 10.1007/s40200-025-01782-7. eCollection 2025 Dec. PMID- 41206960 OWN - NLM STAT- MEDLINE DCOM- 20260217 LR - 20260723 IS - 1464-360X (Electronic) IS - 1101-1262 (Linking) VI - 36 IP - 1 DP - 2026 Feb 1 TI - Global index of lifestyle quality and non-suicidal self-injury in the SESSAMO project: a Spanish adolescents cohort. PG - 77-83 LID - 10.1093/eurpub/ckaf159 [doi] AB - Adolescents' failure to embrace healthy lifestyles constitutes a serious public health issue, such that its relationship to non-suicidal self-injury (NSSI) merits further research. The aim of the study was to ascertain the association between a Global Index of Lifestyle Quality (GILQ) and the presence of NSSI. Cross-sectional analysis of a sample of 2nd- to 4th-year ESO students (Obligatory Secondary Education, from ages 14 to 16) recruited for the SESSAMO project, a multicenter prospective cohort study. Exposure variables were collected, including eating patterns, physical activity, screen use, the consumption of cannabis, alcohol and tobacco, risky sexual behavior, gambling, spend time with friends, and sleep quality. To determine the presence of NSSI, a validated questionnaire was administered. The association between different lifestyles and the presence of NSSI was analyzed through multivariate logistic regression models. 2042 adolescents were included. Physical activity, screen use, risky sexual behavior, sleep quality, and daytime sleepiness showed inverse and statistically significant associations with the presence of NSSI in multivariate models. A higher lifestyle score was associated with a 71% reduction in the likelihood of engaging in NSSI (OR for extreme quartiles of GILQ adherence =0.29; 95% CI = 0.15-0.57). The result was similar when boys and girls were analyzed separately. A healthy lifestyle was inversely associated with the presence of NSSI in this sample of Spanish adolescents. Lifestyles could function as potential predictors of NSSI. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of the European Public Health Association. FAU - Goni-Sarries, Adriana AU - Goni-Sarries A AUID- ORCID: 0000-0003-2624-3724 AD - Mental Health Network, Navarre Health Service, Navarre, Spain. AD - IdiSNA, Navarre Institute for Health Research, Navarre, Spain. FAU - Morata-Sampaio, Leticia AU - Morata-Sampaio L AUID- ORCID: 0000-0003-2177-9001 AD - Department of Psychology, Sociology, and Social Work, University Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain. FAU - Diez-Suarez, Azucena AU - Diez-Suarez A AUID- ORCID: 0000-0002-1531-9351 AD - IdiSNA, Navarre Institute for Health Research, Navarre, Spain. AD - Child and Adolescents Psychiatry Unit, Clinica Universidad de Navarra, Navarre, Spain. FAU - Pirez, Guillermo AU - Pirez G AD - Children and Adolescent Psychiatry at Insular University Hospital of Gran Canaria, Las Palmas de Gran Canaria, Spain. AD - Department of Medical Sciences, Area of Psychiatry, University Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain. FAU - Zorrilla, Inaki AU - Zorrilla I AUID- ORCID: 0000-0001-6444-8208 AD - OSI Araba, Osakidetza Basque Health Service, Vitoria-Gasteiz, Spain. AD - Department of Neurosciences, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain. AD - CIBER of Mental Health (CIBERSAM), Institute of Health Carlos III, Madrid, Spain. FAU - Sanchez-Villegas, Almudena AU - Sanchez-Villegas A AUID- ORCID: 0000-0001-7733-9238 AD - IdiSNA, Navarre Institute for Health Research, Navarre, Spain. AD - ISFOOD, Institute for Innovation & Sustainable Development in Food Chain, Public University of Navarre, Navarre, Spain. AD - CIBEROBN, Biomedical Research Center Network on Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain. LA - eng GR - Institute of Health Carlos III(ISCIII)/ GR - PI20/00133/European Regional Development Fund (ERDF)/ GR - PI24/00028/European Regional Development Fund (ERDF)/ GR - PI20/00133/European Regional Development Fund/ GR - PI24/00028/European Regional Development Fund/ PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't PL - England TA - Eur J Public Health JT - European journal of public health JID - 9204966 SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - Spain/epidemiology MH - *Life Style MH - Cross-Sectional Studies MH - Prospective Studies MH - *Self-Injurious Behavior/epidemiology MH - Surveys and Questionnaires MH - *Adolescent Behavior/psychology MH - Cohort Studies EDAT- 2025/11/09 18:25 MHDA- 2026/02/18 00:49 CRDT- 2025/11/09 16:52 PHST- 2026/02/18 00:49 [medline] PHST- 2025/11/09 18:25 [pubmed] PHST- 2025/11/09 16:52 [entrez] AID - 8317475 [pii] AID - 10.1093/eurpub/ckaf159 [doi] PST - ppublish SO - Eur J Public Health. 2026 Feb 1;36(1):77-83. doi: 10.1093/eurpub/ckaf159. PMID- 41206777 OWN - NLM STAT- MEDLINE DCOM- 20260202 LR - 20260202 IS - 2326-3660 (Electronic) IS - 0091-3847 (Linking) VI - 54 IP - 1 DP - 2026 Feb TI - Development and validation of a pre-screening tool for early detection of low bone mineral density in female athletes (PreST-LBMD). PG - 63-74 LID - 10.1080/00913847.2025.2586448 [doi] AB - BACKGROUND: The prevalence of low bone mineral density (BMD) among female athletes is higher than that among their male counterparts up to 40%. Low BMD increases the risk of stress fractures. PURPOSE: To examine factors associated with low BMD in female athletes, and to develop, test, and evaluate a Pre-screening Tool for Early Detection of Low BMD in Female Athletes (PreST-LBMD). METHOD: The development and validation groups (381 and 233 subjects, respectively) underwent a medical interview and a BMD test at the lumbar spine using dual-energy X-ray absorptiometry (DXA). A Z-score < -1 was classified as low BMD. After extracting factors associated with low BMD from univariate logistic regression and multivariate least absolute shrinkage and selection operator (LASSO) regression analyses, each variable was scored based on the beta coefficients from LASSO regression to create the PreST-LBMD. The development model was validated using receiver operating characteristic (ROC) curves. Furthermore, using external validation data, sensitivity, negative predictive value (NPV), and area under the curve (AUC) were calculated to evaluate the performance of PreST-LBMD. RESULT: Factors associated with low BMD included age at menarche, amenorrhea for more than 1 year during the teenage years, current duration of amenorrhea, body mass index, history of stress fractures, and exercise load. The calculated cutoff value for a high likelihood of low BMD was 3 points, with a sensitivity of 0.83 (0.79-0.88), a negative predictive value of 0.85 (0.81-0.90), and an area under the curve of 0.74 (0.67-0.81). CONCLUSION: We successfully developed the PreST-LBMD, which showed promising results identifying female athletes with low BMD. Those scoring >/=3 should be assessed by DXA and evaluated for the likelihood of low BMD by the athlete's health and performance team. FAU - Nose-Ogura, Sayaka AU - Nose-Ogura S AD - Department of Sports Medicine, Japan Institute of Sports Sciences, Japan High Performance Sport Center, Tokyo, Japan. AD - Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan. FAU - Yoshino, Osamu AU - Yoshino O AD - Department of Obstetrics and Gynecology, The University of Yamanashi, Yamanashi, Japan. FAU - Kinoshita, Sakiko AU - Kinoshita S AD - Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan. FAU - Nakamura-Kamoto, Hiroe AU - Nakamura-Kamoto H AD - Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan. FAU - Tabei, Katsuyuki AU - Tabei K AD - Department of Radiology, The University of Tokyo, Tokyo, Japan. FAU - Komatsu, Takayuki AU - Komatsu T AD - Department of Sports Medicine, Faculty of Medicine, Juntendo University, Tokyo, Japan. FAU - Hamai, Ayano AU - Hamai A AD - Department of General Medicine, Awa Regional Medical Center, Chiba, Japan. FAU - Iida, Kengo AU - Iida K AD - Kaneko & Iwamatsu Law Office, Tokyo, Japan. FAU - Koshimizu, Takako AU - Koshimizu T AD - Department of Food Science Faculty of Home Economics, Otsuma Women's University, Tokyo, Japan. FAU - Nakayama, Haruo AU - Nakayama H AD - Department of Neurosurgery Medicine, Toho University Ohasi Medical Center, Tokyo, Japan. FAU - Fujiya, Hiroto AU - Fujiya H AD - Department of Sports Medicine, St Marianna University School of Medicine, Kanagawa, Japan. FAU - Manabe, Tomohiro AU - Manabe T AD - Sports Medicine Research Center, Keio University, Kanagawa, Japan. FAU - Yamasawa, Fumihiro AU - Yamasawa F AD - Marubeni Health Promotion Center, Tokyo, Japan. FAU - Segato Kruse, Joao Gabriel AU - Segato Kruse JG AD - Graduate School of Engineering Science, Osaka University, Osaka, Japan. FAU - Kaneko, Miki AU - Kaneko M AD - Graduate School of Engineering Science, Osaka University, Osaka, Japan. FAU - Harada, Miyuki AU - Harada M AD - Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan. FAU - Hiraike, Osamu AU - Hiraike O AD - Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan. FAU - Musha, Haruki AU - Musha H AD - Department of Neurosurgery Medicine, Toho University Ohasi Medical Center, Tokyo, Japan. FAU - Kiyono, Ken AU - Kiyono K AD - Graduate School of Engineering Science, Osaka University, Osaka, Japan. FAU - Osuga, Yutaka AU - Osuga Y AD - Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan. FAU - Nakajima, Kohei AU - Nakajima K AD - Department of Sports Medicine, Japan Institute of Sports Sciences, Japan High Performance Sport Center, Tokyo, Japan. LA - eng PT - Journal Article PT - Validation Study DEP - 20251120 PL - England TA - Phys Sportsmed JT - The Physician and sportsmedicine JID - 0427461 SB - IM MH - Humans MH - Female MH - *Bone Density MH - Absorptiometry, Photon MH - *Athletes MH - Adult MH - Young Adult MH - Adolescent MH - Early Diagnosis MH - Lumbar Vertebrae/diagnostic imaging MH - ROC Curve MH - Fractures, Stress MH - Mass Screening/methods MH - Risk Factors OTO - NOTNLM OT - Amenorrhea OT - Relative Energy Deficiency in Sport OT - estrogen OT - low energy availability OT - menarche OT - osteoporosis EDAT- 2025/11/09 14:46 MHDA- 2026/02/02 23:57 CRDT- 2025/11/09 07:13 PHST- 2026/02/02 23:57 [medline] PHST- 2025/11/09 14:46 [pubmed] PHST- 2025/11/09 07:13 [entrez] AID - 10.1080/00913847.2025.2586448 [doi] PST - ppublish SO - Phys Sportsmed. 2026 Feb;54(1):63-74. doi: 10.1080/00913847.2025.2586448. Epub 2025 Nov 20. PMID- 41204588 OWN - NLM STAT- MEDLINE DCOM- 20251108 LR - 20260730 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 104 IP - 45 DP - 2025 Nov 7 TI - Construction and validation of a column-line diagram predictive model for the development of preeclampsia in women with twin pregnancies: A retrospective study. PG - e45407 LID - 10.1097/MD.0000000000045407 [doi] LID - e45407 AB - This study investigates risk factors for the development of preeclampsia (PE) in women with twin pregnancies and constructs and validates a column-line diagram prediction model for clinical decision-making. Records of 70 women with PE and 70 women without PE were selected from twin pregnancies who underwent labor and delivery at Huzhou Maternity and Child Health Care Hospital between September 2021 and June 2023. The cohort was then divided into a training set (98 cases) and a validation set (42 cases) in the ratio of 7:3 using a simple random sampling method. Clinical risk factors, blood biochemical indexes, and uterine artery pulsatility index of all pregnant women were collected to assess the risk of PE. The results were presented as odds ratios (OR) with 90% confidence intervals (CI). Least absolute shrinkage and selection operator regression analysis was used to screen the predictors and establish an optimized, multifactorial logistic regression-based columnar graph model. Distinction, calibration, and clinical utility of the columnar plot model were evaluated by using the receiver operator characteristic curve, calibration plot, and decision curve analysis. Age (OR = 13.39, 95% CI = 2.152-157.0, P = .014), prepregnancy body mass index (OR = 5.979, 95% CI = 1.365-34.27, P = .027), mode of conception (OR = 3.498, 95% CI = 1.071-12.79, P = .045), serum homocysteine cysteine level (OR = 2.079, 95% CI = 1.193-4.005, P = .016), serum beta-human chorionic gonadotropin level (Log10; OR = 9.984, 95% CI = 1.467-82.77, P = .024), uterine artery pulsatility index (per0.1; OR = 1.347, 95% CI = 1.11-1.7, P = .005) were independent risk factors for PE (P < .05), and the column-line graph prediction model based on the above 6 risk factors had a good discriminatory degree (area under curve value: 0.880, 95% CI = 0.817-0.944 for training set validation, and 0.831, 95% CI = 0.704-0.958 for validation set validation). The calibration curve showed good agreement between the predicted and actual probabilities of the model (P > .05), and the decision curve analysis showed that the model had a high net clinical benefit (threshold probability values: >2.5% for the training set, 18% to 75% for the validation set). The column-line diagram model developed in this study can more accurately predict the risk of developing PE in women with twin pregnancies. CI - Copyright (c) 2025 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Lu, Yan AU - Lu Y AUID- ORCID: 0009-0002-5324-3842 AD - Department of Obstetrics and Gynecology, Huzhou Maternity & Child Health Care Hospital, Huzhou, Zhejiang, PR China. FAU - Li, Qiongshan AU - Li Q AD - Department of Obstetrics and Gynecology, Huzhou Maternity & Child Health Care Hospital, Huzhou, Zhejiang, PR China. FAU - Meng, Diyun AU - Meng D AD - Department of Obstetrics and Gynecology, Huzhou Maternity & Child Health Care Hospital, Huzhou, Zhejiang, PR China. FAU - Mei, Lina AU - Mei L AD - Department of Internal Medicine, Huzhou Maternity & Child Health Care Hospital, Huzhou, Zhejiang, PR China. FAU - Ding, Zhongying AU - Ding Z AD - Department of Laboratory, Huzhou Maternity & Child Health Care Hospital, Huzhou, Zhejiang, PR China. FAU - Li, Wenwen AU - Li W AD - Department of Laboratory, Huzhou Maternity & Child Health Care Hospital, Huzhou, Zhejiang, PR China. FAU - Chu, Hua AU - Chu H AD - Department of Ultrasound, Huzhou Maternity & Child Health Care Hospital, Huzhou, Zhejiang, PR China. FAU - Qin, Lin AU - Qin L AD - Department of Ultrasound, Huzhou Maternity & Child Health Care Hospital, Huzhou, Zhejiang, PR China. LA - eng PT - Journal Article PT - Observational Study PT - Validation Study PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Pre-Eclampsia/diagnosis/epidemiology/etiology MH - *Pregnancy, Twin MH - Retrospective Studies MH - Adult MH - Risk Factors MH - ROC Curve MH - Uterine Artery/diagnostic imaging MH - Risk Assessment/methods MH - Logistic Models MH - China/epidemiology PMC - PMC12599651 OTO - NOTNLM OT - columnar graph OT - predictive model OT - preeclampsia OT - twin pregnancy COIS- The authors have no funding and conflicts of interest to disclose. EDAT- 2025/11/08 06:28 MHDA- 2025/11/08 06:29 PMCR- 2025/11/07 CRDT- 2025/11/08 01:03 PHST- 2025/06/30 00:00 [received] PHST- 2025/09/29 00:00 [accepted] PHST- 2025/11/08 06:29 [medline] PHST- 2025/11/08 06:28 [pubmed] PHST- 2025/11/08 01:03 [entrez] PHST- 2025/11/07 00:00 [pmc-release] AID - 00005792-202511070-00132 [pii] AID - MD-D-25-08002 [pii] AID - 10.1097/MD.0000000000045407 [doi] PST - ppublish SO - Medicine (Baltimore). 2025 Nov 7;104(45):e45407. doi: 10.1097/MD.0000000000045407. PMID- 41204518 OWN - NLM STAT- MEDLINE DCOM- 20251108 LR - 20260730 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 104 IP - 45 DP - 2025 Nov 7 TI - Association between serum uric acid to high-density lipoprotein cholesterol ratio and female infertility in women aged 18 to 45 years: A study based on NHANES 2013 to 2018. PG - e45736 LID - 10.1097/MD.0000000000045736 [doi] LID - e45736 AB - The uric acid (UA) to HDL-cholesterol ratio (UHR) has recently been proposed as a novel marker of cardiometabolic and inflammatory risk. This study aimed to investigate the association between UHR and infertility in U.S. women of reproductive age. We analyzed data from 2447 women aged 18 to 45 years in the National Health and Nutrition Examination Survey (NHANES) 2013 to 2018 cycles. The primary outcome - infertility - was assessed based on self-reported responses from the reproductive health questionnaire of the National Health And Nutrition Examination Survey dataset, and was not clinically validated. UHR was calculated as the ratio of serum UA to HDL-C. Multivariable logistic regression models were constructed to evaluate the association between UHR and infertility risk. Women with infertility had significantly higher mean age, body mass index, UA levels, and log (UHR) values compared to non-infertile participants (all P <.01). In the fully adjusted model, each unit increase in log-transformed UHR was associated with a higher odd of infertility (OR = 2.04, 95% CI: 1.28-3.27, P = .01). Compared with the lowest quartile of UHR, the adjusted odds ratios for infertility were 1.72 (95% CI: 1.09-2.72) for Q2, 1.91 (95% CI: 1.17-3.12) for Q3, and 1.98 (95% CI: 1.15-3.41) for Q4 (P for trend = .017). Subgroup analyses revealed consistent associations across women aged >/=35 years, those living with a partner, never-smokers, women without diabetes mellitus or hypertension, and those with regular menstrual periods or a history of pelvic infection, although no significant interactions were observed. Elevated UHR is associated with an increased risk of infertility in reproductive-aged women, as observed in this cross-sectional analysis. However, due to the study's cross-sectional nature, causality cannot be inferred, and further prospective studies are needed to validate these findings. CI - Copyright (c) 2025 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Zhang, Heng AU - Zhang H AUID- ORCID: 0009-0004-5872-8245 AD - Pharmacy Department, Huaibei Miners' General Hospital, Huaibei, Anhui, China. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R RN - 268B43MJ25 (Uric Acid) RN - 0 (Cholesterol, HDL) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Adult MH - *Uric Acid/blood MH - Nutrition Surveys MH - Middle Aged MH - *Infertility, Female/blood/epidemiology MH - Young Adult MH - *Cholesterol, HDL/blood MH - Adolescent MH - Biomarkers/blood MH - Cross-Sectional Studies MH - United States/epidemiology MH - Risk Factors PMC - PMC12599660 OTO - NOTNLM OT - NHANES OT - infertility OT - inflammation OT - reproductive health OT - uric acid to HDL-cholesterol ratio (UHR) COIS- The author has no conflicts of interest to disclose. EDAT- 2025/11/08 06:28 MHDA- 2025/11/08 06:29 PMCR- 2025/11/07 CRDT- 2025/11/08 01:02 PHST- 2025/07/31 00:00 [received] PHST- 2025/10/06 00:00 [accepted] PHST- 2025/11/08 06:29 [medline] PHST- 2025/11/08 06:28 [pubmed] PHST- 2025/11/08 01:02 [entrez] PHST- 2025/11/07 00:00 [pmc-release] AID - 00005792-202511070-00061 [pii] AID - MD-D-25-09541 [pii] AID - 10.1097/MD.0000000000045736 [doi] PST - ppublish SO - Medicine (Baltimore). 2025 Nov 7;104(45):e45736. doi: 10.1097/MD.0000000000045736. PMID- 41204212 OWN - NLM STAT- MEDLINE DCOM- 20251108 LR - 20251110 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Nov 7 TI - Health literacy of pregnant women and its association with methyl-group donor intake and folic acid supplementation: a cross-sectional study. PG - 3844 LID - 10.1186/s12889-025-25239-x [doi] LID - 3844 AB - BACKGROUND: Adequate health literacy (HL) can be particularly important among pregnant women, as it can have an impact on maternal and fetal health. Deliberate intake of folate through food and folic acid supplementation (FAs) is essential for women in reproductive age. Dietary intake of methyl-group donors (MGDs) via maternal nutrition may influence the infant's health and may affect reproductive outcomes through epigenetic mechanisms. OBJECTIVE: The aim of our study was to assess HL in relation to (MGD) intake among pregnant women, and to assess health knowledge as part of health literacy. METHODS: 124 pregnant women were involved in this cross-sectional study. Data were collected using two validated HL questionnaires, and a food frequency questionnaire (FFQ) to estimate MGD intake. Statistical analyses included the calculation of means, correlation coefficients, and multiple linear regression analysis. RESULTS: The HL of pregnant women was found problematic (50.8% Newest Vital Sign Test, NVS; 46.7% Brief Health Literacy Screening Tool, BRIEF). The estimated intake of dietary folate, methionine, choline and betaine were 264.7 +/- 134.6 microg/d; 2303 +/- 1209 mg/d; 248.1 +/- 110.8 mg/d, and 127.1 +/- 65.8 mg/d (mean +/- standard deviation, SD), respectively. Before pregnancy 58.87% of respondents did not take FAs; during pregnancy, this decreased to 31.45%. CONCLUSION: Pregnant women did not reach adequate HL. Further evaluation of health literacy, MGD intake, is required to formulate suitable nutritional intake for pregnant women in Hungary. It is suggested that providing better information to pregnant women could improve their adherence to folic acid supplementation recommendations. CI - (c) 2025. The Author(s). FAU - Csolle, Ildiko AU - Csolle I AD - Doctoral School of Health Sciences, University of Pecs, Pecs, Hungary. csolle.ildiko@pte.hu. AD - Cochrane Hungary, Medical School, University of Pecs, Pecs, Hungary. csolle.ildiko@pte.hu. FAU - Kovacs, Attila AU - Kovacs A AD - Cochrane Hungary, Medical School, University of Pecs, Pecs, Hungary. AD - Department of Biophysics, Medical School, University of Pecs, Pecs, Hungary. FAU - Bokor, Szilvia AU - Bokor S AD - National Laboratory of Human Reproduction, University of Pecs, Pecs, Hungary. AD - Department of Paediatrics, Medical School, University of Pecs, Pecs, Hungary. FAU - Funke, Simone AU - Funke S AD - National Laboratory of Human Reproduction, University of Pecs, Pecs, Hungary. AD - Department of Obstetrics and Gynaecology, Medical School, University of Pecs, Pecs, Hungary. FAU - Vass, Reka A AU - Vass RA AD - National Laboratory of Human Reproduction, University of Pecs, Pecs, Hungary. AD - Department of Obstetrics and Gynaecolog, Magyar Imre Hospital, Ajka, Hungary. FAU - Ertl, Tibor AU - Ertl T AD - National Laboratory of Human Reproduction, University of Pecs, Pecs, Hungary. AD - Department of Obstetrics and Gynaecology, Medical School, University of Pecs, Pecs, Hungary. FAU - Molnar, Denes AU - Molnar D AD - National Laboratory of Human Reproduction, University of Pecs, Pecs, Hungary. AD - Department of Paediatrics, Medical School, University of Pecs, Pecs, Hungary. LA - eng PT - Journal Article DEP - 20251107 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - 935E97BOY8 (Folic Acid) RN - AE28F7PNPL (Methionine) RN - N91BDP6H0X (Choline) RN - 3SCV180C9W (Betaine) SB - IM MH - Humans MH - Female MH - *Folic Acid/administration & dosage MH - Cross-Sectional Studies MH - Pregnancy MH - *Health Literacy/statistics & numerical data MH - Adult MH - *Dietary Supplements MH - *Pregnant People/psychology MH - Surveys and Questionnaires MH - Young Adult MH - Methionine/administration & dosage MH - Choline/administration & dosage MH - Betaine/administration & dosage PMC - PMC12595826 OTO - NOTNLM OT - BRIEF OT - Folate OT - Folic acid OT - Health literacy OT - Methyl-group donor OT - NVS OT - Pregnant women COIS- Declarations. Ethics approval and consent to participate: The study was conducted according to the guidelines defined in the Declaration of Helsinki, and the procedure was approved by Regional Science and Research Committee of University of Pecs, Hungary. The authorisation number is: 8753-PTE 2023. All participants were given informed consent and the opportunity to ask questions before the survey. Written informed consent was obtained from all participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/08 00:28 MHDA- 2025/11/08 06:28 PMCR- 2025/11/07 CRDT- 2025/11/07 23:52 PHST- 2024/07/30 00:00 [received] PHST- 2025/10/09 00:00 [accepted] PHST- 2025/11/08 06:28 [medline] PHST- 2025/11/08 00:28 [pubmed] PHST- 2025/11/07 23:52 [entrez] PHST- 2025/11/07 00:00 [pmc-release] AID - 10.1186/s12889-025-25239-x [pii] AID - 25239 [pii] AID - 10.1186/s12889-025-25239-x [doi] PST - epublish SO - BMC Public Health. 2025 Nov 7;25(1):3844. doi: 10.1186/s12889-025-25239-x. PMID- 41204205 OWN - NLM STAT- MEDLINE DCOM- 20251108 LR - 20260925 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 25 IP - 1 DP - 2025 Nov 7 TI - Development and multicenter validation of a novel model for selective screening of gestational diabetes mellitus: the Vietnam gestational diabetes mellitus study. PG - 1171 LID - 10.1186/s12884-025-08249-w [doi] LID - 1171 AB - AIMS: Gestational diabetes mellitus is commonly observed in pregnant women and is associated with an increased risk of adverse outcomes for both mother and child, not only during pregnancy but also in the long term thereafter. The present study aimed to develop a predictive nomogram for gestational diabetes mellitus in pregnant women. MATERIALS AND METHODS: This multicenter prospective cohort study enrolled 1,398 pregnant women from five major obstetric hospitals in Vietnam's Mekong Delta. GDM was diagnosed based on the 2017 American Diabetes Association criteria. Using Bayesian Model Averaging, the optimal prediction model was identified in the primary cohort (n = 978) and used to construct a nomogram for individualized risk estimation. Model performance was validated in an independent cohort (n = 420), with assessment of discrimination (AUC), calibration (Brier score), and clinical utility (decision curve analysis). RESULTS: The prevalence of GDM was 18.0% (95%CI: 16.0-20.1). The final model included maternal age (OR per year: 1.09; 95%CI: 1.06-1.13), history of macrosomia (OR: 6.04; 95%CI: 2.76-13.19), body mass index (OR per kg/m(2): 1.62; 95%CI: 1.25-2.10), and weight gain during pregnancy (OR per kg: 1.12; 95%CI: 1.06-1.18). The model demonstrated good discriminative ability and calibration in the primary cohort (AUC = 0.74, 95%CI: 0.69-0.78; Brier score = 0.123), and acceptable performance in the validation cohort (AUC = 0.70; 95%CI: 0.63-0.77; Brier score = 0.139). The nomogram showed good calibration and yielded higher net benefit across a wide range of risk thresholds (0.1-0.4) in decision curve analysis, indicating strong clinical utility. CONCLUSIONS: A nomogram incorporating four routinely assessed clinical parameters offers good predictive accuracy for gestational diabetes mellitus. This model may facilitate early identification and targeted intervention for high-risk pregnant women in both resource-limited and clinical settings. CI - (c) 2025. The Author(s). FAU - Tran, Nga K AU - Tran NK AUID- ORCID: 0009-0006-0390-7988 AD - Can Tho University of Medicine and Pharmacy, 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, 902510, Vietnam. tknga@ctump.edu.vn. FAU - Cao, Thanh N AU - Cao TN AUID- ORCID: 0000-0001-6362-0934 AD - University of Medicine and Pharmacy, Hue University, Hue City, Vietnam. thanhykhue@yahoo.com. FAU - Pham, Linh V AU - Pham LV AD - Hong Bang International University, Ho Chi Minh City, Vietnam. FAU - Lam, Tam D AU - Lam TD AD - Can Tho University of Medicine and Pharmacy, 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, 902510, Vietnam. FAU - Vo, Trinh A T AU - Vo TAT AD - Can Tho University of Medicine and Pharmacy, 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, 902510, Vietnam. FAU - Nguyen, Thu T AU - Nguyen TT AD - Can Tho University of Medicine and Pharmacy, 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, 902510, Vietnam. FAU - Nguyen, Nghia N AU - Nguyen NN AD - Can Tho University of Medicine and Pharmacy, 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, 902510, Vietnam. FAU - Chau, Dang H AU - Chau DH AD - Hong Bang International University, Ho Chi Minh City, Vietnam. FAU - Nguyen, Bao T AU - Nguyen BT AD - University of Medicine and Pharmacy, Hue University, Hue City, Vietnam. LA - eng PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20251107 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Diabetes, Gestational/diagnosis/epidemiology MH - Vietnam/epidemiology MH - Adult MH - *Nomograms MH - Prospective Studies MH - Bayes Theorem MH - Risk Assessment/methods MH - Prevalence MH - *Mass Screening/methods MH - Risk Factors MH - Body Mass Index MH - Maternal Age PMC - PMC12595668 OTO - NOTNLM OT - Gestational diabetes mellitus OT - Nomogram OT - Predictive model OT - Risk factors COIS- Declarations. Ethics approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the Ethics Committee of University of Medicine and Pharmacy, Hue University, Vietnam (No. 1435/QD-DHYD). Consent to participate: Informed consent was obtained from all individual participants included in the study. Consent to publish: Additional informed consent was obtained from all individual participants for whom identifying information is included in this article. Competing interests: The authors declare no competing interests. EDAT- 2025/11/08 00:28 MHDA- 2025/11/08 06:29 PMCR- 2025/11/07 CRDT- 2025/11/07 23:51 PHST- 2025/06/30 00:00 [received] PHST- 2025/09/16 00:00 [accepted] PHST- 2025/11/08 06:29 [medline] PHST- 2025/11/08 00:28 [pubmed] PHST- 2025/11/07 23:51 [entrez] PHST- 2025/11/07 00:00 [pmc-release] AID - 10.1186/s12884-025-08249-w [pii] AID - 8249 [pii] AID - 10.1186/s12884-025-08249-w [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2025 Nov 7;25(1):1171. doi: 10.1186/s12884-025-08249-w. PMID- 41199311 OWN - NLM STAT- MEDLINE DCOM- 20251107 LR - 20260727 IS - 1479-5876 (Electronic) IS - 1479-5876 (Linking) VI - 23 IP - 1 DP - 2025 Nov 6 TI - The impact of 4-week high-intensity interval training on mental health and sleep quality in female college students with normal weight obesity: a randomized controlled trial. PG - 1234 LID - 10.1186/s12967-025-07276-7 [doi] LID - 1234 AB - BACKGROUND: Normal Weight obesity, characterized by normal-range body mass index accompanied by elevated adiposity, poses a potential health challenge among female college students. This demographic exhibits heightened susceptibility to psychological disturbances and sleep disorders. High-Intensity Interval Training (HIIT) appears to have potential in managing metabolic dysregulation. However, its efficacy in improving mental health and sleep quality in individuals with normal weight obesity remains uncertain. METHODS: This randomized controlled trial enrolled female college students (N = 35) who met the criteria for normal weight obesity, defined as a body mass index between 20 and 23 kg/m(2) and a body fat percentage greater than 30%. The intervention group (n = 17) participated in a 4-week HIIT protocol, consisting of five sessions per week at greater than 90% VO(2)max, while the control group (n = 18) received standard health education. Validated instruments were utilized to assess depression (PHQ-9), anxiety (GAD-7), and sleep quality (PSQI). TRIAL REGISTRATION: ChiCTR2100050711 Registered 3 September 2021 Retrospectively registered, https//www.chictr.org.cn/showproj.html? proj=132,914. RESULTS: The HIIT intervention significantly reduced PHQ-9 scores from 5.8 +/- 4.2 to 3.2 +/- 2.7 (p < 0.01) and GAD-7 scores from 5.1 +/- 5.3 to 2.8 +/- 2.9 (p < 0.05), while also improving PSQI scores from 5.1 +/- 3.4 to 3.5 +/- 2.5 (p < 0.01). Post-intervention analyses revealed a strong correlation between sleep quality and levels of depression (R = 0.813, p < 0.001) and anxiety (R = 0.739, p < 0.001) in the HIIT group, whereas no significant change in sleep quality was observed among the control group. CONCLUSION: This study demonstrates the therapeutic efficacy of HIIT in improving psychological disturbances and sleep architecture in female students with normal weight obesity. It may serve as a time-efficient intervention. The observed correlation between sleep quality and psychological parameters warrants further investigation into the underlying mechanisms. CI - (c) 2025. The Author(s). FAU - Fu, Jiawen AU - Fu J AD - College of Rehabilitation Sciences, Shanghai University of Medicine and Health Sciences, Shanghai, China. FAU - Zhang, Wangyi AU - Zhang W AD - College of Rehabilitation Sciences, Shanghai University of Medicine and Health Sciences, Shanghai, China. FAU - Xu, Xinyi AU - Xu X AD - College of Rehabilitation Sciences, Shanghai University of Medicine and Health Sciences, Shanghai, China. FAU - Mao, Xinyi AU - Mao X AD - College of Rehabilitation Sciences, Shanghai University of Medicine and Health Sciences, Shanghai, China. FAU - Wang, Liyan AU - Wang L AD - College of Rehabilitation Sciences, Shanghai University of Medicine and Health Sciences, Shanghai, China. FAU - Cai, Ming AU - Cai M AD - College of Rehabilitation Sciences, Shanghai University of Medicine and Health Sciences, Shanghai, China. FAU - Yang, Ruoyu AU - Yang R AUID- ORCID: 0000-0002-8815-4439 AD - College of Rehabilitation Sciences, Shanghai University of Medicine and Health Sciences, Shanghai, China. yangry@sumhs.edu.cn. LA - eng GR - C2024206/Education and Scientific Research Project of Shanghai/ PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20251106 PL - England TA - J Transl Med JT - Journal of translational medicine JID - 101190741 SB - IM MH - Humans MH - Female MH - *Sleep Quality MH - *Students/psychology MH - Universities MH - *High-Intensity Interval Training MH - *Mental Health MH - *Obesity/psychology/physiopathology/therapy MH - Young Adult MH - Adult MH - *Body Weight MH - Depression MH - *Sleep MH - Adolescent MH - Anxiety PMC - PMC12590694 OTO - NOTNLM OT - Anxiety state OT - Depressive state OT - High-intensity interval training OT - Normal weight obesity OT - Sleep quality COIS- Declarations. Ethics approval and consent to participate: The conduct of this study followed the principles outlined in the Declaration of Helsinki and received ethical clearance from the Ethics Committee of Shanghai University of Medicine and Health Sciences, China. All participants provided written informed consent prior to their involvement in the study. Consent for publication: Not applicable. Competing interests: The authors report no conflicts of interest in this work. EDAT- 2025/11/07 00:27 MHDA- 2025/11/07 06:28 PMCR- 2025/11/06 CRDT- 2025/11/06 23:49 PHST- 2025/05/13 00:00 [received] PHST- 2025/10/08 00:00 [accepted] PHST- 2025/11/07 06:28 [medline] PHST- 2025/11/07 00:27 [pubmed] PHST- 2025/11/06 23:49 [entrez] PHST- 2025/11/06 00:00 [pmc-release] AID - 10.1186/s12967-025-07276-7 [pii] AID - 7276 [pii] AID - 10.1186/s12967-025-07276-7 [doi] PST - epublish SO - J Transl Med. 2025 Nov 6;23(1):1234. doi: 10.1186/s12967-025-07276-7. PMID- 41194895 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251106 LR - 20251108 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 16 DP - 2025 TI - Exploring how cognitive-behavioral physical activity links ruminative thinking and mental wellbeing in sports high school adolescents. PG - 1665882 LID - 10.3389/fpsyg.2025.1665882 [doi] LID - 1665882 AB - INTRODUCTION: This study examined the associations among ruminative thinking style (RTS), subjective wellbeing (SWB), and cognitive-behavioral physical activity (CBPA) in a sample of 1,326 adolescents (aged 14-18) from sports high schools. METHOD: Using validated self-report measures, data were analyzed through bootstrapped mediation models. RESULTS: RTS was negatively associated with SWB (beta = -0.1792, p < 0.001), while CBPA showed a partial mediating effect in this relationship (indirect beta = 0.0779, p < 0.001). DISCUSSION: These results suggest that cognitive-behavioral orientations toward physical activity may buffer the negative impact of rumination on wellbeing. Consistent with cognitive-behavioral therapy (CBT) principles, CBPA could provide adolescents with self-regulatory strategies that support mental health. However, the cross-sectional and self-report design, as well as the focus on sports high school students, limit causal inference and generalizability. Future longitudinal and cross-cultural studies are needed to confirm these findings. Overall, the study provides preliminary evidence that CBPA-informed approaches may hold promise for promoting adolescents' mental wellbeing. CI - Copyright (c) 2025 Derelioglu, Vural, Cimen, Saki, Yagiz Saracoglu, Karatas, Sac, Yamaner, Halmatov, Yilmaz, Oztas, Arikan and Ceylan. FAU - Derelioglu, Mehmet AU - Derelioglu M AD - Department of Exercise and Sport Science, Faculty of Sports Sciences, Avrasya University, Trabzon, Turkiye. FAU - Vural, Mustafa AU - Vural M AD - Department of Sport Management, Faculty of Sports Sciences, Agri Ibrahim Cecen University, Agri, Turkiye. FAU - Cimen, Erkan AU - Cimen E AD - Department of Physical Education and Sport, Faculty of Sports Sciences, Suleyman Demirel University, Isparta, Turkiye. FAU - Saki, Unal AU - Saki U AD - Department of Physical Education and Sport, Faculty of Sports Sciences, Agri Ibrahim Cecen University, Agri, Turkiye. FAU - Yagiz Saracoglu, Yusuf AU - Yagiz Saracoglu Y AD - Department of Sport Management, Faculty of Sports Sciences, Agri Ibrahim Cecen University, Agri, Turkiye. FAU - Karatas, Baykal AU - Karatas B AD - Department of Coaching Education, Faculty of Sports Sciences, Agri Ibrahim Cecen University, Agri, Turkiye. FAU - Sac, Ajlan AU - Sac A AD - Department of Coaching Education, Faculty of Sport Sciences, Trakya University, Edirne, Turkiye. FAU - Yamaner, Emre AU - Yamaner E AD - Sungurlu Vocational College, Hitit University, Corum, Turkiye. FAU - Halmatov, Medera AU - Halmatov M AD - Department of Child Development, Faculty of Health Sciences, Bilecik Seyh Edebali University, Bilecik, Turkiye. FAU - Yilmaz, Coskun AU - Yilmaz C AD - Department of Management and Organization, Kelkit Aydin Dogan Vocational College, Gumushane University, Gumushane, Turkiye. FAU - Oztas, Mehmet AU - Oztas M AD - Department of Physical Education and Sport, Faculty of Sports Sciences, Tokat Gaziosmanpasa University, Tokat, Turkiye. FAU - Arikan, Gokhan AU - Arikan G AD - Department of Physical Education and Sport, School of Physical Education and Sports, Harran University, Sanliurfa, Turkiye. FAU - Ceylan, Levent AU - Ceylan L AD - Department of Sport Management, Faculty of Sports Sciences, Hitit University, Corum, Turkiye. LA - eng PT - Journal Article DEP - 20251021 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC12583217 OTO - NOTNLM OT - adolescent mental health OT - cognitive-behavioral therapy OT - physical activity interventions OT - ruminative thought patterns OT - subjective wellbeing COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/11/06 06:29 MHDA- 2025/11/06 06:30 PMCR- 2025/10/21 CRDT- 2025/11/06 04:04 PHST- 2025/07/14 00:00 [received] PHST- 2025/10/03 00:00 [accepted] PHST- 2025/11/06 06:30 [medline] PHST- 2025/11/06 06:29 [pubmed] PHST- 2025/11/06 04:04 [entrez] PHST- 2025/10/21 00:00 [pmc-release] AID - 10.3389/fpsyg.2025.1665882 [doi] PST - epublish SO - Front Psychol. 2025 Oct 21;16:1665882. doi: 10.3389/fpsyg.2025.1665882. eCollection 2025. PMID- 41194531 OWN - NLM STAT- MEDLINE DCOM- 20251106 LR - 20260927 IS - 1098-2302 (Electronic) IS - 0012-1630 (Print) IS - 0012-1630 (Linking) VI - 67 IP - 6 DP - 2025 Nov TI - Advancing Wrist-Worn Accelerometry for Measurement of Infant Motor Behavior. PG - e70098 LID - 10.1002/dev.70098 [doi] LID - e70098 AB - Wearable sensor technology, particularly accelerometry, is an emerging tool to measure infant motor behavior. We evaluated (1) differences and relationships between accelerometry-derived variables in structured versus unstructured contexts and (2) the convergent validity of accelerometer-derived variables with coded motor behavior during structured motor tasks and with caregiver reports of infant motor behavior. Typically developing infants (n = 176, 6 months adjusted age) were evaluated via bilateral wrist-worn accelerometers during structured, laboratory toy play tasks and at home for 2 days, unstructured. Eleven accelerometer variables quantifying duration, intensity, and variability of movement were extracted from each context and analyzed with respect to five variables from the video-coded structured toy play task and caregiver report (Ages and Stages Questionnaire motor subscales). Infants and parents tolerated the devices as indicated by a usable data rate equivalent to the questionnaire response rate. Accelerometry values from the structured context were generally larger than those from the unstructured context, except for the variance variables. Values across the contexts were moderately and consistently related. Accelerometry variables were related to video-coded variables but were only minimally related to caregiver reports of fine motor behavior. Upper limb accelerometry is a feasible, valid addition to the infant motor measurement toolbox. CI - (c) 2025 The Author(s). Developmental Psychobiology published by Wiley Periodicals LLC. FAU - Lang, Catherine E AU - Lang CE AUID- ORCID: 0000-0002-7120-0136 AD - Program in Physical Therapy, WashU Medicine, St. Louis, Missouri, USA. AD - Department of Neurology, WashU Medicine, St. Louis, Missouri, USA. AD - Program in Occupational Therapy, WashU Medicine, St. Louis, Missouri, USA. FAU - Iverson, Jana M AU - Iverson JM AD - Department of Physical Therapy, Boston University, Boston, Massachusetts, USA. FAU - Konrad, Jeffery D AU - Konrad JD AD - Program in Physical Therapy, WashU Medicine, St. Louis, Missouri, USA. AD - Department of Neurology, WashU Medicine, St. Louis, Missouri, USA. FAU - Lorence, Audrey S AU - Lorence AS AD - Department of Physical Therapy, Boston University, Boston, Massachusetts, USA. FAU - Choudhry, Izza AU - Choudhry I AD - Department of Physical Therapy, Boston University, Boston, Massachusetts, USA. FAU - Bland, Marghuretta D AU - Bland MD AD - Program in Physical Therapy, WashU Medicine, St. Louis, Missouri, USA. AD - Department of Neurology, WashU Medicine, St. Louis, Missouri, USA. AD - Program in Occupational Therapy, WashU Medicine, St. Louis, Missouri, USA. FAU - Campbell, Meghan AU - Campbell M AD - Department of Psychiatry, WashU Medicine, St. Louis, Missouri, USA. FAU - White, Stormi Pulver AU - White SP AD - Department of Pediatrics, Emory School of Medicine, Atlanta, Georgia, USA. AD - Marcus Center for Autism, Children's Healthcare of Atlanta, Atlanta, Georgia, USA. FAU - Balser, Dorothy H AU - Balser DH AD - Department of Pediatrics, Emory School of Medicine, Atlanta, Georgia, USA. FAU - Adebogun, Motunrola B AU - Adebogun MB AD - Department of Pediatrics, Emory School of Medicine, Atlanta, Georgia, USA. FAU - Islam, Nailah AU - Islam N AD - Marcus Center for Autism, Children's Healthcare of Atlanta, Atlanta, Georgia, USA. FAU - Pileggi, Moira L AU - Pileggi ML AD - Marcus Center for Autism, Children's Healthcare of Atlanta, Atlanta, Georgia, USA. FAU - Davis, Savannah C AU - Davis SC AD - Department of Psychiatry, WashU Medicine, St. Louis, Missouri, USA. FAU - Dieffenbacher, Madeline S AU - Dieffenbacher MS AD - Department of Psychiatry, WashU Medicine, St. Louis, Missouri, USA. FAU - Lohse, Keith R AU - Lohse KR AD - Program in Physical Therapy, WashU Medicine, St. Louis, Missouri, USA. AD - Program in Occupational Therapy, WashU Medicine, St. Louis, Missouri, USA. FAU - Marrus, Natasha AU - Marrus N AD - Department of Psychiatry, WashU Medicine, St. Louis, Missouri, USA. LA - eng GR - R01 MH123723/MH/NIMH NIH HHS/United States GR - T32 HD007434/HD/NICHD NIH HHS/United States GR - T32HD007434/NH/NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PL - United States TA - Dev Psychobiol JT - Developmental psychobiology JID - 0164074 SB - IM MH - Humans MH - *Accelerometry/instrumentation/methods MH - Infant MH - Male MH - Female MH - *Infant Behavior/physiology MH - Wrist/physiology MH - *Motor Activity/physiology MH - *Wearable Electronic Devices MH - Reproducibility of Results PMC - PMC12589933 OTO - NOTNLM OT - infant OT - measurement OT - motor behavior OT - movement OT - upper limb OT - wearable sensors COIS- The authors declare no conflicts of interest. EDAT- 2025/11/06 06:28 MHDA- 2025/11/06 06:29 PMCR- 2025/11/06 CRDT- 2025/11/06 02:13 PHST- 2025/11/06 06:29 [medline] PHST- 2025/11/06 06:28 [pubmed] PHST- 2025/11/06 02:13 [entrez] PHST- 2025/11/06 00:00 [pmc-release] AID - DEV70098 [pii] AID - 10.1002/dev.70098 [doi] PST - ppublish SO - Dev Psychobiol. 2025 Nov;67(6):e70098. doi: 10.1002/dev.70098. PMID- 41194043 OWN - NLM STAT- MEDLINE DCOM- 20251106 LR - 20251108 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 25 IP - 1 DP - 2025 Nov 5 TI - APPL1 concentration as a potential biomarker in early-onset preeclampsia: correlations with adiponectin-leptin dysregulation and adverse neonatal outcomes. PG - 1167 LID - 10.1186/s12884-025-08368-4 [doi] LID - 1167 AB - BACKGROUND: Preeclampsia (PE) is a severe pregnancy complication associated with metabolic dysregulation. APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) is a critical adaptor protein in adiponectin (ADP) and insulin signaling. Its role in preeclampsia (PE) remains underexplored. This study investigates APPL1 as a potential biomarker for early-onset PE and its links to adipokine imbalance, glycolipid metabolism, and neonatal outcomes. METHODS: A case-control study enrolled 116 pregnant women (45 PE vs. 71 controls) from a single center. Serum APPL1, ADP, and leptin (LEP) levels of all 116 participants were measured. Glycolipid metabolism indices and neonatal outcomes were collected. The correlation was analyzed by simple linear regression, and the logistic regression was used to evaluate the predictive effects of APPL1, ADP and LEP on PE. RESULTS: (1) Prepregnancy BMI (22.15 +/- 1.80 vs. 21.03 +/- 1.99 kg/m(2), p = 0.0028), APPL1 (82.65 +/- 8.27 vs. 62.21 +/- 12.41 pg/mL, p = 0.0047) and LEP (12.60 +/- 2.83 vs. 8.66 +/- 1.77 ng/mL, p = 0.0004). (2) APPL1 positively correlated with ADP only in PE (r = 0.0921, p = 0.0456). (3) Logistic regression identified APPL1 (OR = 1.405, p = 0.003) and LEP (OR = 3.618, p = 0.006) as PE risk factors, with ADP as protective (OR = 0.299, p = 0.003). (4) APPL1 showed extensive relationships with glycolipid dysregulation in PE (p < 0.05). (5) In PE, APPL1 inversely predicted adverse neonatal outcomes, including neonatal birth weight (r=-0.0149, p = 0.0396), ponderal index (r=-0.0198, p = 0.0024) and Apgar score (r=-0.0368, p = 0.0225). CONCLUSIONS: Elevated APPL1 is a potential and novel biomarker for early-onset PE, and reflecting adiponectin-leptin dysregulation, glycolipid metabolic disturbances, and adverse neonatal prognosis. Its integration into clinical prediction models warrants further validation. CI - (c) 2025. The Author(s). FAU - Zhu, Qianmeng AU - Zhu Q AD - Department of Obstetrics and Gynecology, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, Jiangsu, 215101, China. FAU - Zhou, Yuzhen AU - Zhou Y AD - Department of Obstetrics and Gynecology, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, Jiangsu, 215101, China. FAU - Huang, Yan AU - Huang Y AD - Department of Obstetrics and Gynecology, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, Jiangsu, 215101, China. FAU - Chi, Xiaoli AU - Chi X AD - Department of Obstetrics and Gynecology, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, Jiangsu, 215101, China. 18913552361@163.com. LA - eng GR - YJ2021011/Science and Technology Project of Suzhou Hospital of Integrated Traditional Chinese and Western Medicine/ GR - SYSD2018047/Suzhou Science and Technology Development Plan Project - Basic Research on Medical and Health Application/ PT - Journal Article DEP - 20251105 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 RN - 0 (APPL1 protein, human) RN - 0 (Biomarkers) RN - 0 (Adiponectin) RN - 0 (Leptin) RN - 0 (Adaptor Proteins, Signal Transducing) RN - 0 (ADIPOQ protein, human) SB - IM MH - Humans MH - Female MH - Pregnancy MH - Biomarkers/blood MH - *Adiponectin/blood MH - *Pre-Eclampsia/blood/diagnosis MH - *Leptin/blood MH - Case-Control Studies MH - Adult MH - *Adaptor Proteins, Signal Transducing/blood MH - Infant, Newborn MH - Pregnancy Outcome PMC - PMC12590627 OTO - NOTNLM OT - APPL1 OT - Adiponectin OT - Biomarker OT - Leptin OT - Preeclampsia COIS- Declarations. Ethics approval and consent to participate: The study design and protocol were approved and adopted by the Ethics Committee of the Suzhou Hospital of Integrated Traditional Chinese and Western Medicine on January 09, 2023 with approval number of 2023(022). All procedures involving human participants were conducted in compliance with the World Medical Association Declaration of Helsinki ( https://www.wma.net/policies-post/wma-declaration-of-helsinki/ ). All participants provided written informed consent freely upon enrollment in the study. Consent for publication: Not applicable. This manuscript does not contain any identifying images, personal information, or clinical details of participants that could compromise their anonymity. Competing interests: The authors declare no competing interests. EDAT- 2025/11/06 00:27 MHDA- 2025/11/06 06:28 PMCR- 2025/11/05 CRDT- 2025/11/05 23:46 PHST- 2025/07/14 00:00 [received] PHST- 2025/10/13 00:00 [accepted] PHST- 2025/11/06 06:28 [medline] PHST- 2025/11/06 00:27 [pubmed] PHST- 2025/11/05 23:46 [entrez] PHST- 2025/11/05 00:00 [pmc-release] AID - 10.1186/s12884-025-08368-4 [pii] AID - 8368 [pii] AID - 10.1186/s12884-025-08368-4 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2025 Nov 5;25(1):1167. doi: 10.1186/s12884-025-08368-4. PMID- 41193827 OWN - NLM STAT- MEDLINE DCOM- 20260108 LR - 20261009 IS - 1476-5640 (Electronic) IS - 0954-3007 (Linking) VI - 80 IP - 1 DP - 2026 Jan TI - Effect of a mobile phone application for dietary self-monitoring on obesity in adolescents: a pilot randomized controlled trial. PG - 96-103 LID - 10.1038/s41430-025-01676-0 [doi] AB - BACKGROUND/OBJECTIVES: The global prevalence of obesity among children and adolescents is a growing concern, with significant implications for long-term health outcomes. Traditional weight loss programs focusing on diet and physical activity have shown limited efficacy. This study aimed to assess the impact of the FatSecret mobile application, a dietary self-monitoring tool, on BMI z-score (ZBMI) in adolescents with obesity, alongside clinical and metabolic parameters, body composition, dietary intake, binge eating behaviors, and quality of life. SUBJECTS/METHODS: Sixty adolescents aged 13-17 years with obesity were randomly assigned to either the application group (balanced energy-restricted diet with daily self-monitoring using the FatSecret app) or the control group (balanced energy-restricted diet with a 3-day food record). Both groups were followed for 6 months with monthly consultations, and 34 patients completed the intervention. RESULTS: Both groups experienced significant improvements in ZBMI, body composition, binge eating scores, and insulin levels. Notably, the FatSecret app demonstrated comparable effectiveness to the validated 3-day food record in supporting weight loss and behavioral improvements. While the control group reported a greater increase in polyunsaturated fat intake, the app group showed significant improvements in pain-related quality of life scores. Adherence to dietary monitoring and dropout rates were similar between groups. CONCLUSION: The use of a mobile phone application demonstrated effectiveness comparable to the traditional, validated 3-day food record in promoting weight loss and metabolic improvements among adolescents with obesity. These findings support its use as a practical alternative for dietary self-monitoring. CI - (c) 2025. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Audi, Andrea Samara AU - Audi AS AUID- ORCID: 0000-0002-1660-1615 AD - Grupo de Obesidade e Sindrome Metabolica, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil. andreaaudi1@gmail.com. FAU - Fernandes, Ariana Ester AU - Fernandes AE AUID- ORCID: 0000-0002-9522-8213 AD - Grupo de Obesidade e Sindrome Metabolica, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil. FAU - Coelho, Graziele Souza de Menezes Amorim AU - Coelho GSMA AD - Grupo de Obesidade e Sindrome Metabolica, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil. FAU - Moura, Aline Maria da Silva Hourneaux de AU - Moura AMDSH AD - Grupo de Obesidade e Sindrome Metabolica, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil. FAU - Pepe, Renata Bressan AU - Pepe RB AD - Grupo de Obesidade e Sindrome Metabolica, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil. FAU - Cercato, Cintia AU - Cercato C AD - Grupo de Obesidade e Sindrome Metabolica, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil. FAU - Melo, Maria Edna de AU - Melo ME AD - Grupo de Obesidade e Sindrome Metabolica, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil. FAU - Mancini, Marcio C AU - Mancini MC AD - Grupo de Obesidade e Sindrome Metabolica, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20251105 PL - England TA - Eur J Clin Nutr JT - European journal of clinical nutrition JID - 8804070 SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - *Mobile Applications MH - Pilot Projects MH - *Pediatric Obesity/diet therapy/therapy MH - Quality of Life MH - Body Mass Index MH - Body Composition MH - Weight Loss MH - Diet Records MH - Diet, Reducing COIS- Competing interests: The authors declare no competing interests. Ethical approval: The study was approved by the ethics committee of the institution (Comite de Etica em Pesquisa-CEP; CAEE: 88935218.2.0000.0068) and was conducted according to the Helsinki Declaration. EDAT- 2025/11/06 00:27 MHDA- 2026/01/09 00:26 CRDT- 2025/11/05 23:35 PHST- 2024/11/08 00:00 [received] PHST- 2025/10/24 00:00 [accepted] PHST- 2025/09/21 00:00 [revised] PHST- 2026/01/09 00:26 [medline] PHST- 2025/11/06 00:27 [pubmed] PHST- 2025/11/05 23:35 [entrez] AID - 10.1038/s41430-025-01676-0 [pii] AID - 10.1038/s41430-025-01676-0 [doi] PST - ppublish SO - Eur J Clin Nutr. 2026 Jan;80(1):96-103. doi: 10.1038/s41430-025-01676-0. Epub 2025 Nov 5. PMID- 41191532 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260714 IS - 1662-4033 (Electronic) IS - 1662-4025 (Print) IS - 1662-4025 (Linking) VI - 19 IP - 4 DP - 2026 TI - Predictors of Body Weight Loss and Body Weight Loss Maintenance in Children and Adolescents following Inpatient Multidisciplinary Obesity Treatment. PG - 351-364 LID - 10.1159/000548602 [doi] AB -

Introduction: To improve pediatric obesity treatment, this study aimed to identify predictors of body weight loss (BWL) and its maintenance (BWLM) in children and adolescents. METHODS: Data from 59 hospitalized children and adolescents with obesity (aged 9-17, mean 13.4 +/- 1.9 years; mean length of stay: 38 +/- 9.1 days) were collected at admission (T1), at discharge (T2), and up to 24 months thereafter (T5). Predictors of BWL (DeltaT1-T2) (mean 0.33 +/- 0.14 BMI z-score) and BWLM (DeltaT2-T5) were categorized into demographic, psychometric, and sociometric data, physical condition, autonomic nervous system functions, and eating behavior. Secondary outcomes included changes in body composition and motor performance. Predictors were analyzed using LASSO [Journal of the Royal Statistical Society. 1996;58(1):267-288] and hierarchical regression. RESULTS: Energy density and food intake consistently predicted BWL and BWLM. Body dissatisfaction (p = 0.016), better anger management (less anger-related emotion regulation in the Stress and Stress Coping Questionnaire) (p = 0.031), smell identification skills, higher initial motor performance and strength, and lower initial endurance predicted BWL. A positive attitude toward healthy eating (p < 0.001), its improvement over time (p = 0.027), lower parasympathetic withdrawal - indicated by a smaller relative change in Root Mean Square of Successive Differences (RMSSDs) from baseline to stress (%RMSSD change, p = 0.022) - and high salt sensitivity (p < 0.001) significantly predicted BWLM. CONCLUSION: This study provides initial indications that energy intake, in interaction with psychological and physiological factors, may be relevant to understanding BWL and BWLM in pediatric obesity, warranting further investigation.

. CI - (c) 2025 The Author(s). Published by S. Karger AG, Basel. FAU - Weiland, Alisa AU - Weiland A AD - Department of Psychomatic Medicine and Psychotherapy, University Medical Hospital, Tubingen, Germany. FAU - Kasemann, Lena AU - Kasemann L AD - Department of Psychomatic Medicine and Psychotherapy, University Medical Hospital, Tubingen, Germany. FAU - Sauer, Helene AU - Sauer H AD - Department of Psychomatic Medicine and Psychotherapy, University Medical Hospital, Tubingen, Germany. FAU - Horing, Bjorn AU - Horing B AD - Department of General Psychology and Cognitive Neuroscience, Charlotte Fresenius University of Psychology, Hamburg, Germany. FAU - Zipfel, Stephan AU - Zipfel S AD - Department of Psychomatic Medicine and Psychotherapy, University Medical Hospital, Tubingen, Germany. FAU - Mazurak, Nazar AU - Mazurak N AD - Department of Psychomatic Medicine and Psychotherapy, University Medical Hospital, Tubingen, Germany. FAU - Enck, Paul AU - Enck P AD - Department of Psychomatic Medicine and Psychotherapy, University Medical Hospital, Tubingen, Germany. FAU - Mack, Isabelle AU - Mack I AD - Department of Psychomatic Medicine and Psychotherapy, University Medical Hospital, Tubingen, Germany, isabelle.mack@uni-tuebingen.de. LA - eng PT - Journal Article DEP - 20251105 PL - Switzerland TA - Obes Facts JT - Obesity facts JID - 101469429 SB - IM MH - Humans MH - Child MH - Female MH - Adolescent MH - *Weight Loss MH - Male MH - Energy Intake MH - *Pediatric Obesity/therapy/psychology MH - Feeding Behavior MH - Body Mass Index MH - Body Dissatisfaction MH - Body Composition MH - Inpatients MH - Anger MH - Adaptation, Psychological MH - Body Satisfaction PMC - PMC12807519 OTO - NOTNLM OT - Body weight loss OT - Body weight loss maintenance OT - Pediatric obesity OT - Predictors COIS- The authors declare no conflict of interest. EDAT- 2025/11/05 18:30 MHDA- 2026/07/14 18:41 PMCR- 2025/11/05 CRDT- 2025/11/05 13:12 PHST- 2025/05/28 00:00 [received] PHST- 2025/09/09 00:00 [accepted] PHST- 2026/07/14 18:41 [medline] PHST- 2025/11/05 18:30 [pubmed] PHST- 2025/11/05 13:12 [entrez] PHST- 2025/11/05 00:00 [pmc-release] AID - 000548602 [pii] AID - 548602 [pii] AID - 10.1159/000548602 [doi] PST - ppublish SO - Obes Facts. 2026;19(4):351-364. doi: 10.1159/000548602. Epub 2025 Nov 5. PMID- 41189863 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251105 LR - 20251107 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 17 IP - 10 DP - 2025 Oct TI - Comparing Stress, Anxiety, and Depression in Adolescent Practitioners of Hatha Yoga and Recreational Sports: A Cross-Sectional Study. PG - e95723 LID - 10.7759/cureus.95723 [doi] LID - e95723 AB - BACKGROUND: Adolescents are vulnerable to psychiatric conditions, with depression, stress, and anxiety being particularly common. Prior research suggests that physical activities such as recreational sports and yoga may benefit mental health. However, limited comparative data exist on these interventions for managing adolescent mental health. AIM: This study aimed to examine whether stress, anxiety, and depression levels differ between adolescent yoga and sports practitioners. METHODS: A cross-sectional study of 190 adolescents was conducted, including 95 Hatha yoga practitioners and 95 recreational sports participants. Mental health outcomes were assessed using the Depression Anxiety Stress Scales (DASS-21). Independent samples t-tests and chi-square tests were used to compare groups, with p 0.05). The ROC curve analysis revealed that NPAR exhibited good univariable discrimination in identifying complicated appendicitis (AUC = 0.811, 95%CI: 0.777-0.844). CONCLUSION: NPAR shows promise as a readily accessible biomarker derived from routine blood tests for risk stratification of complicated appendicitis in pediatric patients. The identified non-linear association pattern provides valuable insights for clinical risk assessment. Internal validation confirmed the stability of our model, and these findings warrant further validation in prospective multicenter studies before broad clinical implementation. CI - (c) 2025. The Author(s). FAU - Liu, Ming AU - Liu M AD - Department of Pediatric Surgery, Suining Central Hospital, No. 127 of Desheng West Road, Chuanshan District, Suining, Sichuan Province, 629000, People's Republic of China. FAU - Tang, Zaihui AU - Tang Z AD - Department of Pediatric Surgery, Suining Central Hospital, No. 127 of Desheng West Road, Chuanshan District, Suining, Sichuan Province, 629000, People's Republic of China. FAU - Gou, Yunpeng AU - Gou Y AD - Department of Pediatric Surgery, Suining Central Hospital, No. 127 of Desheng West Road, Chuanshan District, Suining, Sichuan Province, 629000, People's Republic of China. FAU - Yang, Ping AU - Yang P AD - Department of Pediatric Surgery, Suining Central Hospital, No. 127 of Desheng West Road, Chuanshan District, Suining, Sichuan Province, 629000, People's Republic of China. 13320245381@163.com. LA - eng PT - Journal Article DEP - 20251103 PL - England TA - BMC Gastroenterol JT - BMC gastroenterology JID - 100968547 RN - 0 (Biomarkers) RN - 0 (Serum Albumin) RN - 9007-41-4 (C-Reactive Protein) SB - IM MH - Humans MH - *Appendicitis/surgery/blood/complications MH - Retrospective Studies MH - Male MH - Female MH - Child MH - Appendectomy MH - *Neutrophils MH - Risk Assessment/methods MH - Adolescent MH - Child, Preschool MH - Biomarkers/blood MH - ROC Curve MH - *Serum Albumin/analysis MH - Leukocyte Count MH - Laparoscopy MH - Preoperative Period MH - C-Reactive Protein PMC - PMC12581459 OTO - NOTNLM OT - Biomarker OT - Children OT - Complicated appendicitis OT - Neutrophil percentage-to-albumin ratio COIS- Declarations. Ethics approval and consent to participate: This retrospective study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of Suining Central Hospital. Due to the retrospective nature of the study, the requirement for individual informed consent was waived by the Ethics Committee. All patient data were anonymized and de-identified prior to analysis to protect patient privacy and confidentiality. The study only involved review of existing medical records and did not include any intervention or direct patient contact. All procedures performed were part of routine clinical care. Consent for publication: Not applicable. This manuscript does not contain any individual person's data in any form (including individual details, images, or videos). The study only utilized anonymized clinical and laboratory data, with no personally identifiable information included in the analysis or manuscript. Competing interests: The authors declare no competing interests. EDAT- 2025/11/04 00:28 MHDA- 2025/11/04 06:29 PMCR- 2025/11/03 CRDT- 2025/11/03 23:52 PHST- 2025/07/21 00:00 [received] PHST- 2025/10/09 00:00 [accepted] PHST- 2025/11/04 06:29 [medline] PHST- 2025/11/04 00:28 [pubmed] PHST- 2025/11/03 23:52 [entrez] PHST- 2025/11/03 00:00 [pmc-release] AID - 10.1186/s12876-025-04390-0 [pii] AID - 4390 [pii] AID - 10.1186/s12876-025-04390-0 [doi] PST - epublish SO - BMC Gastroenterol. 2025 Nov 3;25(1):782. doi: 10.1186/s12876-025-04390-0. PMID- 41182842 OWN - NLM STAT- MEDLINE DCOM- 20260306 LR - 20260923 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) VI - 37 IP - 3-4 DP - 2026 Mar-Apr 01 TI - Analysis of the Relationships Between the Eyeball and the Orbit in Patients Under 4 Years Old Using Computed Tomography. PG - e172-e176 LID - 10.1097/SCS.0000000000012103 [doi] AB - OBJECTIVE: The relationship between the orbital ring and the eyeball in the sagittal plane, as observed through computed tomography (CT), is crucial for the surgical approach, correction, and postoperative monitoring (normalization, failure, or recurrence) of craniofacial anomalies affecting the orbital region of the eyeball. The objective of this study is to describe the anthropometric reference points proposed by Mulliken and colleagues and the indices of Waitzman and Posnick using CT in patients under 4 years old. METHODS: A retrospective, observational, descriptive study was conducted on patients under 4 years old who were treated at the Hospital Infantil Universitario de San Jose and Hospital de San Jose in Bogota, between June 2014 and November 2021, and who underwent CT scans of the skull, simple face, and paranasal sinuses. RESULTS: A total of 101 infants were included, with a female predominance. Measurements were higher in boys. The increase in measurements was most noticeable between 0 and 2 years of age. The variability of the measurements is consistent with initial studies on the subject. CONCLUSION: The determination of anthropometric points using computed tomography is a promising tool. The authors recommend validation studies, interobserver assessments, and larger sample sizes to confirm its reliability. CI - Copyright (c) 2025 by Mutaz B. Habal, MD. FAU - Rolando, Jose AU - Rolando J AD - Unit Fundacion Universitaria de Ciencias de la Salud (FUCS), Hospital Infantil Universitario de San Jose. FAU - Madrid, Prada AU - Madrid P AD - Unit Fundacion Universitaria de Ciencias de la Salud (FUCS), Hospital Infantil Universitario de San Jose. FAU - Gomez Prada, Diana C AU - Gomez Prada DC AUID- ORCID: 0000-0001-8352-6531 AD - Fundacion Universitaria de Ciencias de la Salud (FUCS), Hospital Infantil Universitario de San Jose, Center for Children with Cleft Lip and Palate (FISULAB). FAU - Riano Montanez, Fabian AU - Riano Montanez F AD - Radiology and Diagnostic Imaging program, Fundacion Universitaria de Ciencias de la Salud (FUCS), Hospital Infantil Universitario de San Jose. FAU - Segura Laiton, Wilber S AU - Segura Laiton WS AD - Fundacion Universitaria de Ciencias de la Salud (FUCS), Hospital Infantil Universitario de San Jose. FAU - Bittar Cardenas, Meggy P AU - Bittar Cardenas MP AD - Fundacion Universitaria de Ciencias de la Salud (FUCS), Bogota, Colombia. FAU - Tristancho Martinez, Lady J AU - Tristancho Martinez LJ AD - Fundacion Universitaria de Ciencias de la Salud (FUCS), Bogota, Colombia. FAU - Lopez Buendia, Santiago AU - Lopez Buendia S AD - Fundacion Universitaria de Ciencias de la Salud (FUCS), Bogota, Colombia. LA - eng PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20251103 PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 SB - IM MH - Humans MH - Female MH - Retrospective Studies MH - Male MH - *Tomography, X-Ray Computed/methods MH - *Orbit/diagnostic imaging/anatomy & histology MH - Infant MH - Child, Preschool MH - *Eye/diagnostic imaging/anatomy & histology MH - Infant, Newborn OTO - NOTNLM OT - Exophthalmometry OT - maxillofacial computed tomography OT - orbital anthropometer OT - orbitometry OT - sagittal orbit-globe relationship COIS- The authors report no conflicts of interest. EDAT- 2025/11/03 18:30 MHDA- 2026/03/06 19:43 CRDT- 2025/11/03 12:13 PHST- 2025/05/07 00:00 [received] PHST- 2025/09/10 00:00 [accepted] PHST- 2026/03/06 19:43 [medline] PHST- 2025/11/03 18:30 [pubmed] PHST- 2025/11/03 12:13 [entrez] AID - 00001665-202603000-00131 [pii] AID - 10.1097/SCS.0000000000012103 [doi] PST - ppublish SO - J Craniofac Surg. 2026 Mar-Apr 01;37(3-4):e172-e176. doi: 10.1097/SCS.0000000000012103. Epub 2025 Nov 3. PMID- 41179766 OWN - NLM STAT- MEDLINE DCOM- 20251103 LR - 20251105 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Mental health and health-related behaviors in Chinese college students: the role of physical education. PG - 1688244 LID - 10.3389/fpubh.2025.1688244 [doi] LID - 1688244 AB - BACKGROUND: University physical education (PE) class may promote healthier behaviors and better mental health, yet evidence on their impact in higher education is limited. This study examined associations between PE participation, mental health, health-related behaviors, and sleep quality among Chinese university students. METHODS: A cross-sectional survey was conducted among 2,117 s-year undergraduate students, using proportional stratified sampling in 2024. Validated instruments were used to collect data: demographics and anthropometrics (self-report height and weight to calculate BMI); International Physical Activity Questionnaire-Short Form (IPAQ-SF) for total weekly physical activity; General Health Questionnaire-12 (GHQ-12) for mental health; Pittsburgh Sleep Quality Index (PSQI) for sleep quality; and self-reported screen time. To objectively assess activity levels during PE lessons, ActiGraph wGT3X-BT accelerometers were used. Logistic and multiple linear regression analyses identified associations and predictors of mental health, health-related behaviors, and MVPA proportion during PE class. RESULTS: In linear models, total physical activity (beta = 0.17, p = 0.003), greater MVPA during PE (beta = 0.19, p = 0.003), and shorter screen time (beta = -0.14, p = 0.009) predicted better mental health. On average, students spent 48.6% of PE lesson time in MVPA. A higher MVPA proportion was associated with lower odds of obesity (OR = 0.41, p < 0.001), physical inactivity (OR = 0.38, p < 0.001), and poor sleep quality (OR = 0.72, p = 0.004). Male students had greater odds of obesity (OR = 3.14, p < 0.001) and smoking (OR = 2.02, p = 0.001), while females reported poorer sleep. Predictors of MVPA proportion in PE included higher BMI (beta = -0.11, p < 0.001), female gender (beta = -0.14, p < 0.001), poorer sleep quality (beta = -0.09, p = 0.003), and lower mental health (beta = 0.11, p = 0.002). CONCLUSION: PE class may provide an important context for promoting health-related behaviors and mental health among university students. However, given the cross-sectional design, causal relationships cannot be inferred. Longitudinal and intervention studies are needed to confirm these findings and clarify underlying mechanisms. CI - Copyright (c) 2025 Xu, Zhou and Tian. FAU - Xu, Qing AU - Xu Q AD - Business School, Shaoxing University, Shaoxing, Zhejiang, China. FAU - Zhou, Zan AU - Zhou Z AD - Institute of Physical Education, Shaoxing University, Shaoxing, Zhejiang, China. FAU - Tian, Zhongfei AU - Tian Z AD - Beijing Health Vocational College, Beijing, China. LA - eng PT - Journal Article DEP - 20251016 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Male MH - Female MH - *Students/psychology/statistics & numerical data MH - Cross-Sectional Studies MH - *Mental Health/statistics & numerical data MH - Universities MH - China MH - *Health Behavior MH - Young Adult MH - Exercise MH - *Physical Education and Training/statistics & numerical data MH - Surveys and Questionnaires MH - Adult MH - Sleep Quality MH - Adolescent PMC - PMC12571594 OTO - NOTNLM OT - mental health OT - obesity OT - physical activity OT - physical education OT - sleep OT - students COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/11/03 13:42 MHDA- 2025/11/03 13:43 PMCR- 2025/10/16 CRDT- 2025/11/03 07:01 PHST- 2025/08/18 00:00 [received] PHST- 2025/09/26 00:00 [accepted] PHST- 2025/11/03 13:43 [medline] PHST- 2025/11/03 13:42 [pubmed] PHST- 2025/11/03 07:01 [entrez] PHST- 2025/10/16 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1688244 [doi] PST - epublish SO - Front Public Health. 2025 Oct 16;13:1688244. doi: 10.3389/fpubh.2025.1688244. eCollection 2025. PMID- 41178153 OWN - NLM STAT- MEDLINE DCOM- 20251103 LR - 20260813 IS - 1552-6372 (Electronic) IS - 1524-8399 (Print) IS - 1524-8399 (Linking) VI - 26 IP - 6 DP - 2025 Nov TI - From Free Play to Farm Chores: Using the Youth Compendium to Characterize Physical Activity Behaviors Among Rural Children. PG - 1081-1092 LID - 10.1177/15248399241302060 [doi] AB - The physical activity (PA) behaviors of rural youth are not fully understood and community health practitioners often lack practical PA tools to evaluate their activities. The purpose of this study was to use the Youth Compendium, a publicly available PA assessment tool, to identify activities frequently reported among a sample of rural children and to provide translational implications for PA promotion in community settings. Ninety-seven children (mean age=8.9+/-1.1; female=58.8%) who participated in the rural NU-HOME obesity prevention randomized controlled trial completed a 7-day PA log and provided accelerometry data (mean moderate-vigorous PA=44.5+/-18.9 minutes/day). Using the Youth Compendium, multiple research team members independently coded the open-response PA log data to determine specific activity types completed on weekdays and weekends. We established interrater reliability using coder triangulation methods. Activity-specific energy costs and durations were estimated using youth metabolic equivalent of task (METy) and METy-minute values. On weekdays, the most commonly reported activities were free play (75.3%), biking (37.1%), and walking (37.1%); mean METy-minutes=480+/-693, 92+/-210, and 72+/-233, respectively. On weekends, the most commonly reported activities were free play (61.9%), walking (50.5%), and swimming (29.9%); mean METy-minutes=714+/-1009, 151+/-280, and 520+/-1030, respectively. Farm chores were prevalent and were reported on weekdays (9.2%) and weekends (17.5%). Among this rural sample, children reported a diverse range of activities spanning from free play to farm chores. The Youth Compendium is a useful PA assessment tool. However, to support this tool's utility in rural community settings, compendia expansion work is needed to include activities commonly reported by rural youth. FAU - Kramer-Kostecka, Eydie N AU - Kramer-Kostecka EN AUID- ORCID: 0000-0003-4107-6119 AD - University of Minnesota, Minneapolis, MN, USA. FAU - Grace, Stephanie M AU - Grace SM AUID- ORCID: 0000-0002-2592-0474 AD - University of Minnesota, Minneapolis, MN, USA. FAU - Wagner, Brooke E AU - Wagner BE AUID- ORCID: 0000-0002-8969-3653 AD - Duke University, Durham, NC, USA. FAU - Friend, Sarah AU - Friend S AUID- ORCID: 0000-0003-3529-8401 AD - University of Minnesota, Minneapolis, MN, USA. FAU - Beaudette, Jennifer AU - Beaudette J AD - Minneapolis Heart Institute Foundation, Minneapolis, MN, USA. FAU - Barr-Anderson, Daheia J AU - Barr-Anderson DJ AUID- ORCID: 0000-0001-5896-4388 AD - University of Minnesota, Minneapolis, MN, USA. FAU - Fulkerson, Jayne A AU - Fulkerson JA AUID- ORCID: 0000-0002-2110-498X AD - University of Minnesota, Minneapolis, MN, USA. LA - eng GR - R01 HL123699/HL/NHLBI NIH HHS/United States GR - T32 HL150452/HL/NHLBI NIH HHS/United States GR - UL1 TR002494/TR/NCATS NIH HHS/United States PT - Journal Article DEP - 20241230 PL - United States TA - Health Promot Pract JT - Health promotion practice JID - 100890609 SB - IM MH - Humans MH - Female MH - Child MH - Male MH - *Exercise MH - *Rural Population/statistics & numerical data MH - Accelerometry MH - *Play and Playthings MH - Farms MH - *Agriculture PMC - PMC13231992 MID - NIHMS2157412 OTO - NOTNLM OT - Youth Compendium OT - assessment tools OT - community health promotion OT - physical activity OT - rural youth EDAT- 2025/11/03 06:27 MHDA- 2025/11/03 06:28 PMCR- 2026/06/03 CRDT- 2025/11/03 02:03 PHST- 2025/11/03 06:28 [medline] PHST- 2025/11/03 06:27 [pubmed] PHST- 2025/11/03 02:03 [entrez] PHST- 2026/06/03 00:00 [pmc-release] AID - 10.1177/15248399241302060 [doi] PST - ppublish SO - Health Promot Pract. 2025 Nov;26(6):1081-1092. doi: 10.1177/15248399241302060. Epub 2024 Dec 30. PMID- 41177228 OWN - NLM STAT- MEDLINE DCOM- 20260111 LR - 20260909 IS - 1095-8304 (Electronic) IS - 0195-6663 (Print) IS - 0195-6663 (Linking) VI - 218 DP - 2026 Mar 1 TI - Adolescent eating autonomy survey development and exploratory factor analysis. PG - 108371 LID - S0195-6663(25)00524-0 [pii] LID - 10.1016/j.appet.2025.108371 [doi] AB - The development of autonomy over eating may impact nutrition-related disease risk, such as obesity and diabetes. Little is known about how eating autonomy develops throughout childhood and adolescence perhaps due to the absence of survey tools to measure adolescents eating autonomy behavioral engagement. This study developed and validated a comprehensive survey to evaluate adolescent eating autonomy using an iterative item development with content validity, expert review, and exploratory factor analysis (EFA). A sample of United States adolescents (n = 355; 12-17 years) completed surveys, including the newly developed eating autonomy survey, adolescent-reported parental autonomy support, and Comprehensive Feeding Practices (CFPQ), demographics and food insecurity. Maximum Likelihood EFA tested the factor structure of survey items, with estimated factor associations examined by age, sex, BMI, and food insecurity risk. Spearman Correlations examined discriminant and convergent validity of newly identified factors against previously established parental-constructs related to adolescents' eating autonomy; parental autonomy support and food-related parenting practices. Eating autonomy survey factors were found to be sufficiently distinct from previously established constructs; with final 28-item survey loading onto 5 factors: Snack Autonomy, Breakfast and Lunch Autonomy, Food Purchasing and Independence, Parent-granted Autonomy, Contextual control in eating. Initial demographic exploration of eating autonomy factors found that females had more autonomy in most areas, while only select areas of autonomy were associated with adolescent age (3 factors), household food insecurity (2 factors) and adolescent BMI (1 factor). This work begins to delineate and quantify dimensions of adolescents' autonomous eating behaviors yet further scale analyses are needed before the scale can be adopted more widely. Better understanding this unique developmental feature of adolescent eating behavior may reveal associations with a variety of behavioral concerns and health outcomes. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - Ziegler, Amanda M AU - Ziegler AM AD - Nutrition & Health Research Lab, Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, NY, United States of America; Department of Community Health and Health Behavior, University at Buffalo, Buffalo, NY, United States of America; Department of Family Medicine, Jacobs School of Medicine and Biological Sciences, University at Buffalo, Buffalo, NY, United States of America; Center for Ingestive Behavior Research, University at Buffalo, Buffalo, NY, United States of America. Electronic address: Amz9@buffalo.edu. FAU - Hatzinger, Lori A AU - Hatzinger LA AD - Nutrition & Health Research Lab, Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, NY, United States of America; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, United States of America. FAU - Temple, Jennifer L AU - Temple JL AD - Nutrition & Health Research Lab, Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, NY, United States of America; Department of Community Health and Health Behavior, University at Buffalo, Buffalo, NY, United States of America. LA - eng GR - R01 DK106265/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20251101 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - Factor Analysis, Statistical MH - *Personal Autonomy MH - Child MH - *Feeding Behavior/psychology MH - United States MH - Surveys and Questionnaires MH - Parenting MH - *Adolescent Behavior/psychology MH - Food Insecurity MH - Body Mass Index MH - Reproducibility of Results PMC - PMC13552614 MID - NIHMS2204465 OTO - NOTNLM OT - Adolescence OT - Eating autonomy OT - Eating behavior OT - Survey development OT - Survey validation COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/11/03 00:26 MHDA- 2026/01/12 00:37 PMCR- 2026/11/01 CRDT- 2025/11/02 19:11 PHST- 2025/06/13 00:00 [received] PHST- 2025/09/29 00:00 [revised] PHST- 2025/10/28 00:00 [accepted] PHST- 2026/01/12 00:37 [medline] PHST- 2025/11/03 00:26 [pubmed] PHST- 2025/11/02 19:11 [entrez] PHST- 2026/11/01 00:00 [pmc-release] AID - S0195-6663(25)00524-0 [pii] AID - 10.1016/j.appet.2025.108371 [doi] PST - ppublish SO - Appetite. 2026 Mar 1;218:108371. doi: 10.1016/j.appet.2025.108371. Epub 2025 Nov 1. PMID- 41176788 OWN - NLM STAT- MEDLINE DCOM- 20251102 LR - 20251106 IS - 2719-535X (Electronic) IS - 2719-6488 (Print) IS - 1428-345X (Linking) VI - 29 IP - 1 DP - 2025 Feb 1 TI - Impact of Maternal Diet During Pregnancy on Allergic Predisposition in Offspring: Immune Programming Mechanisms. PG - 175-186 LID - 10.34763/jmotherandchild.20252901.d-25-00016 [doi] AB - BACKGROUND: The aim of the study was to determine how dietary habits of pregnant women influence foetal immune programming and susceptibility to allergies in young children. MATERIAL AND METHODS: The study followed 172 healthy women aged 20-38 years from early pregnancy to one year postpartum in Warsaw, Poland. Dietary data were collected at 12, 24, and 36 weeks using a validated questionnaire and three-day food diaries. Immunological analysis of newborn cord blood included multiplex cytokine analysis, flow cytometry, PCR, and pyrosequencing of FOXP3, IL-10, and TGFbeta1 gene promoter regions. RESULTS: The results showed an increased intake of polyunsaturated fatty acids, antioxidants and probiotics, accompanied by a decreased intake of allergenic foods. This was accompanied by a balanced immune profile in neonates: increased interferon gamma (IFN-gamma) (12.36 pg/ml) and IL-10 (9.21 pg/ml), decreased interleukin 4 (IL-4) (5.82 pg/ml) and immunoglobulin E (IgE) (1.62 IU/ml), indicating a decrease in T helper 2 (Th2)-direction. Higher intake of omega-3 polyunsaturated fatty acids was linked to decreased FOXP3 methylation (r = -0.34; p = 0.008), and probiotics to IL-10 demethylation (r = -0.27; p = 0.03). By 12 months, 21.5% of children showed signs of allergic susceptibility, but those born to women with high omega-3 intake (> 13.5 g/day, OR = 0.42; p = 0.005) and probiotics (OR = 0.55; p = 0.027) had lower rates. CONCLUSION: The influence of maternal nutrition during pregnancy on the immune health of the child, in particular on the development of allergic predisposition, has been determined through the mechanisms of gene methylation and changes in the immune profile of newborns. CI - (c) 2025 Maria Zofia Lisiecka. FAU - Lisiecka, Maria Zofia AU - Lisiecka MZ AUID- ORCID: 0009-0000-9028-952X AD - Department of Allergology, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland. LA - eng PT - Journal Article DEP - 20251102 PL - Poland TA - J Mother Child JT - Journal of mother and child JID - 101771247 RN - 0 (Cytokines) SB - IM MH - Humans MH - Female MH - Pregnancy MH - Adult MH - *Hypersensitivity/immunology MH - Infant, Newborn MH - *Diet MH - *Prenatal Exposure Delayed Effects/immunology MH - Poland MH - Young Adult MH - *Maternal Nutritional Physiological Phenomena/immunology MH - Fetal Blood/immunology MH - Probiotics/administration & dosage MH - Male MH - Cytokines/blood PMC - PMC12582150 OTO - NOTNLM OT - cord blood OT - immune tolerance OT - polyunsaturated fatty acids OT - pregnancy OT - probiotics COIS- Conflicts of Interest The author declares that there are no conflicts of interest related to this work. EDAT- 2025/11/02 18:26 MHDA- 2025/11/02 18:27 PMCR- 2025/11/02 CRDT- 2025/11/02 14:13 PHST- 2025/03/27 00:00 [received] PHST- 2025/08/16 00:00 [accepted] PHST- 2025/11/02 18:27 [medline] PHST- 2025/11/02 18:26 [pubmed] PHST- 2025/11/02 14:13 [entrez] PHST- 2025/11/02 00:00 [pmc-release] AID - jmotherandchild.20252901.d-25-00016 [pii] AID - 10.34763/jmotherandchild.20252901.d-25-00016 [doi] PST - epublish SO - J Mother Child. 2025 Nov 2;29(1):175-186. doi: 10.34763/jmotherandchild.20252901.d-25-00016. eCollection 2025 Feb 1. PMID- 41176344 OWN - NLM STAT- MEDLINE DCOM- 20260501 LR - 20260919 IS - 1499-2752 (Electronic) IS - 0315-162X (Print) IS - 0315-162X (Linking) VI - 53 IP - 5 DP - 2026 May 1 TI - Congruence Between Child Self-Reported and Caregiver-Proxy-Reported Health-Related Quality of Life in Children With Juvenile Idiopathic Arthritis and Systemic Lupus Erythematosus. PG - 537-546 LID - 10.3899/jrheum.2025-0598 [doi] AB - OBJECTIVE: To explore congruence between child self-reported and caregiver-proxy-reported health-related quality of life (HRQOL) over time in juvenile idiopathic arthritis (JIA) and childhood-onset systemic lupus erythematosus (cSLE), and to identify factors associated with the level of congruence. METHODS: Data were from an observational, longitudinal cohort study conducted to validate the Patient-Reported Outcomes Measurement Information System (PROMIS) measures. HRQOL was assessed at baseline, 6, and 12 months. Four hundred fifty-one children (8-17 years) diagnosed with JIA or cSLE and their caregivers completed the PROMIS Pediatric and Parent Proxy measures, respectively. A 1-way random-effects model was used to estimate the intraclass correlation coefficient (ICC) for congruence between child and caregiver reports, and multivariable mixed-effect models were used to identify associated demographic and clinical factors. RESULTS: The study cohort (87.1% JIA) had a mean age of 13.8 years and were 71.4% female. Across all HRQOL domains, child self-reported and caregiver-proxy-reported mobility, physical activity, fatigue, pain interference, depressive symptoms, and psychological stress had moderate associations (ICC 0.50-0.68), whereas child self-reported and caregiver-proxy-reported family relationships and anxiety were weakly associated (ICC 0.34-0.42). Older children had higher congruence with their caregivers on symptom domains (0.25 to 0.75 points) than younger children; female children had higher congruence with their caregivers on psychological symptoms (-2.20 to -1.98 points) than male children. CONCLUSION: Caregivers provide complementary information on the physical aspects of HRQOL, with a tendency to estimate worse symptoms and decreased functioning. Child self-report remains the gold standard for understanding HRQOL in pediatric populations with rheumatic diseases. CI - Copyright (c) 2026 by the Journal of Rheumatology. FAU - Chan, Ya-Ning AU - Chan YN AUID- ORCID: 0000-0002-7045-2892 AD - Y.N. Chan, PhD, RN, L. Lin, MS, Department of Population Health Sciences, Duke University, Durham, North Carolina; yaningchan90@gmail.com. FAU - Ardalan, Kaveh AU - Ardalan K AUID- ORCID: 0000-0001-5075-8846 AD - K. Ardalan, MD, MS, Department of Pediatrics, Division of Pediatric Rheumatology, Duke University, Durham, North Carolina. FAU - Lin, Li AU - Lin L AUID- ORCID: 0000-0003-0530-185X AD - Y.N. Chan, PhD, RN, L. Lin, MS, Department of Population Health Sciences, Duke University, Durham, North Carolina. FAU - Chen, Dandan AU - Chen D AUID- ORCID: 0000-0003-1936-080X AD - D. Chen, PhD, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts. FAU - Weitzman, Elissa R AU - Weitzman ER AUID- ORCID: 0000-0003-1299-0008 AD - E.R. Weitzman, ScD, MSc, Department of Pediatrics, Harvard Medical School, and Division of Adolescent/Young Adult Medicine, Boston Children's Hospital, Boston, Massachusetts. FAU - Dedeoglu, Fatma AU - Dedeoglu F AUID- ORCID: 0000-0002-7516-0848 AD - F. Dedeoglu, MD, Department of Pediatrics, Harvard Medical School, Division of Immunology, Boston Children's Hospital, Boston, Massachusetts. FAU - Vehe, Richard K AU - Vehe RK AUID- ORCID: 0000-0003-4679-8305 AD - R.K. Vehe, MD, Department of Pediatrics, Division of Pediatric Rheumatology, University of Minnesota, Minneapolis, Minnesota. FAU - von Scheven, Emily AU - von Scheven E AUID- ORCID: 0009-0008-7190-4054 AD - E. von Scheven, MD, MAS, Department of Pediatrics, University of California San Francisco, San Francisco, California. FAU - Kimura, Yukiko AU - Kimura Y AUID- ORCID: 0000-0001-7132-3390 AD - Y. Kimura, MD, Pediatric Rheumatology, Joseph M. Sanzari Children's Hospital, Hackensack Meridian School of Medicine, Nutley, New Jersey. FAU - Schanberg, Laura E AU - Schanberg LE AUID- ORCID: 0000-0002-1913-6472 AD - L.E. Schanberg, MD, Department of Pediatrics, Duke University, and Duke Clinical Research Institute, Durham, North Carolina. FAU - Reeve, Bryce B AU - Reeve BB AUID- ORCID: 0000-0002-6709-8714 AD - B.B. Reeve, PhD, Department of Population Health Sciences, Duke University, and Department of Pediatrics, Duke University, and Duke Clinical Research Institute, Durham, North Carolina, USA. CN - CARRA Registry Investigators LA - eng GR - U19 AR069522/AR/NIAMS NIH HHS/United States PT - Journal Article PT - Observational Study PT - Research Support, N.I.H., Extramural DEP - 20260501 PL - Canada TA - J Rheumatol JT - The Journal of rheumatology JID - 7501984 SB - IM MH - Humans MH - Female MH - *Arthritis, Juvenile/psychology/physiopathology MH - Male MH - Child MH - *Quality of Life MH - Adolescent MH - *Caregivers/psychology MH - *Lupus Erythematosus, Systemic/psychology/physiopathology MH - *Self Report MH - Longitudinal Studies MH - Proxy MH - Patient Reported Outcome Measures PMC - PMC12765579 MID - NIHMS2117740 OTO - NOTNLM OT - caregivers OT - health-related quality of life OT - juvenile idiopathic arthritis OT - patient-reported outcome OT - pediatric OT - systemic lupus erythematosus COIS- Competing Interests: During manuscript preparation, Ya-Ning Chan was a Measurement and Regulatory Science (MaRS) fellow at Duke University, which was funded by GSK. Kaveh Ardalan has served on a scientific advisory board of Cabaletta Bio, completed paid consulting for Cabaletta Bio, serves as the Vice Chair of the Juvenile Dermatomyositis Committee for the Childhood Arthritis & Rheumatology Research Alliance (paid consultant position), received honoraria/travel reimbursement from the Rheumatology Research Foundation, honoraria from the American College of Rheumatology, honoraria (paid to institution) from SingHealth for grant pre-review program organized by Office of Duke-NUS Affairs, and receives research funding from the Rheumatology Research Foundation, Childhood Arthritis & Rheumatology Research Alliance/Arthritis Foundation, Chan Zuckerberg Initiative, Cure JM Foundation, Patient-Centered Outcomes Research Institute, and National Institutes of Health/Technical Resources International. Fatma Dedeoglu received speaker's fee from Sobi and royalties from UpToDate for chapter writing. Emily von Scheven receives support from the Childhood Arthritis and Rheumatology Research Alliance. Yukiko Kimura receives salary support from the Childhood Arthritis and Rheumatology Research Alliance and has received research funding from the Patient Centered Outcomes Research Institute and the National Institutes of Health. Laura E. Schanberg serves on advisory boards and receives research grants from Bristol Myers Squibb, serves on a Data and Safety Monitoring Board for Sanofi, UCB, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, serves as an unpaid research consultant for the Childhood Arthritis & Rheumatology Research Alliance, and is the recipient of research grants from the Patient-Centered Outcomes Research Institute. EDAT- 2025/11/02 00:33 MHDA- 2026/05/02 00:33 PMCR- 2026/01/05 CRDT- 2025/11/01 21:12 PHST- 2025/10/08 00:00 [accepted] PHST- 2026/05/02 00:33 [medline] PHST- 2025/11/02 00:33 [pubmed] PHST- 2025/11/01 21:12 [entrez] PHST- 2026/01/05 00:00 [pmc-release] AID - jrheum.2025-0598 [pii] AID - 10.3899/jrheum.2025-0598 [doi] PST - epublish SO - J Rheumatol. 2026 May 1;53(5):537-546. doi: 10.3899/jrheum.2025-0598. PMID- 41174678 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260912 IS - 1472-6874 (Electronic) IS - 1472-6874 (Linking) VI - 25 IP - 1 DP - 2025 Oct 31 TI - Clinical effectiveness and side effect profile of contraceptive implant (Implanon) among women at Sulaimaniyah, Iraq: a cross-sectional study. PG - 530 LID - 10.1186/s12905-025-04072-9 [doi] LID - 530 AB - BACKGROUND: Contraception is an effective way to prevent unintended pregnancies that have a significant impact on women's health and the budget of countries. OBJECTIVES: To assess the clinical effectiveness and side-effect profile of progesterone implant as a contraceptive method among the participants. PATIENTS AND METHODS: This cross-sectional study recruited 101 patients who used a contraceptive implant, Sulaimaniyah, Iraq, from January 2022 to January 2025. Then, participants' sociodemographic and medical data were collected using a self-structured questionnaire validated questionnaire (provided in the supplementary data). Then, the correlations between some variables were determined to find the effectiveness and side effects of the contraceptive implant. RESULTS: About 45.5% of women using a contraceptive implant were aged >/= 35 years, and 36.6% were obese. The common side effects of the contraceptive implant were weight gain (24.8%), headache (23.8%), and loss of libido (19.8%). Most women had a contraceptive implant removed or intended to remove it (54.5%) within 3 years, mainly due to menstrual irregularities (43.6%). During the period when the contraceptive implant was in situ, there was no unintended pregnancy (0.0%), while 75% of women who wished to conceive after removal of the contraceptive implant got pregnant within the first 6 months of removal, indicating early return of fertility after discontinuation of this contraceptive method. Women aged 35 years or older with three or more children experienced significantly more side effects (p /= 0.94). Differential item functioning analysis by sex revealed no significant or practically meaningful bias. In conclusion, the Turkish version of PACES-8 is a valid, reliable, and gender-fair instrument for assessing enjoyment of physical activity. To enhance its discriminative power at higher enjoyment levels, it is recommended to develop additional items that capture deeper emotional and motivational aspects of enjoyment. CI - Copyright (c) 2025 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Altin, Yasin AU - Altin Y AD - Sivas Cumhuriyet University, Faculty of Sports Sciences, Sivas, Turkiye; Ankara University, Institute of Educational Sciences, Ankara, Turkiye. Electronic address: yasinaltin@cumhuriyet.edu.tr. FAU - Ozkurt, Burhan AU - Ozkurt B AD - Sivas Cumhuriyet University, Faculty of Sports Sciences, Sivas, Turkiye. Electronic address: burhanozkurt@cumhuriyet.edu.tr. FAU - Kucukibis, Huseyin Fatih AU - Kucukibis HF AD - Sivas Cumhuriyet University, Faculty of Sports Sciences, Sivas, Turkiye. Electronic address: hfkucukibis@cumhuriyet.edu.tr. LA - eng PT - Journal Article DEP - 20251031 PL - Netherlands TA - Acta Psychol (Amst) JT - Acta psychologica JID - 0370366 SB - IM MH - Humans MH - Male MH - Female MH - *Psychometrics/instrumentation MH - Adult MH - *Exercise/psychology MH - Young Adult MH - Adolescent MH - *Pleasure/physiology MH - Surveys and Questionnaires/standards MH - Turkey MH - Reproducibility of Results MH - Factor Analysis, Statistical OTO - NOTNLM OT - Classical test theory OT - Enjoyment OT - Item response theory OT - Physical activity OT - Psychometrics COIS- Declaration of competing interest The authors declare no conflicts of interest related to this study. EDAT- 2025/11/01 05:37 MHDA- 2025/12/10 06:28 CRDT- 2025/10/31 19:09 PHST- 2025/01/10 00:00 [received] PHST- 2025/10/05 00:00 [revised] PHST- 2025/10/24 00:00 [accepted] PHST- 2025/12/10 06:28 [medline] PHST- 2025/11/01 05:37 [pubmed] PHST- 2025/10/31 19:09 [entrez] AID - S0001-6918(25)01168-0 [pii] AID - 10.1016/j.actpsy.2025.105855 [doi] PST - ppublish SO - Acta Psychol (Amst). 2025 Nov;261:105855. doi: 10.1016/j.actpsy.2025.105855. Epub 2025 Oct 31. PMID- 41172713 OWN - NLM STAT- MEDLINE DCOM- 20251208 LR - 20260313 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 142 DP - 2026 Feb TI - Exploring regional inequities in food safety practices and food security in Italy: A cross-sectional study. PG - 112985 LID - S0899-9007(25)00303-X [pii] LID - 10.1016/j.nut.2025.112985 [doi] AB - OBJECTIVE: This study examined regional disparities in food security and food safety knowledge and behavior among Italian adults. METHODS: Between January and June 2024, we conducted a cross-sectional anonymous online survey targeting Italian residents aged >/=18. The sample size was calculated a priori assuming a 50% prevalence, 95% confidence, and 3% margin of error, yielding a target of 1067 participants. Validated Italian versions of the Food Security Survey Module (It-FSSM) and the Food Safety Knowledge and Behavior Questionnaire (It-FSKB) were employed to assess participants' knowledge and behaviors. Sociodemographic data, including age, sex, body mass index (BMI), educational level, physical activity, smoking habits, and food apps usage, were collected. Multinomial logistic regression-adjusted for age, sex, BMI, and educational level-was used to evaluate regional differences. RESULTS: Among 1752 participants (70.4% women; mean age: 36.01 +/- 13.84 y), those in the South area and Islands were significantly less likely to report high food safety knowledge (relative risk ratio [RRR] = 0.66; 95% confidence interval [CI]: 0.54-0.82; P = 0.000) and high food safety behaviors (RRR = 0.64; 95% CI: 0.52-0.79; P < 0.001), and more likely to experience moderate food insecurity (RRR = 1.64; 95% CI: 1.00-2.69; P = 0.048) compared to participants to the North. Participants in the Center were over twice likely than those in the North to report high food security versus very low (RRR = 2.72; 95% CI: 1.15-6.43; P = 0.023) and were also 30% less likely to use food delivery apps rarely rather than not at all (RRR = 0.70; 95% CI: 0.50-0.97; P = 0.034). CONCLUSIONS: This study highlights significant regional disparities, with the South area and Islands facing the greatest challenges. These findings provide evidence to guide targeted public health interventions and policies promoting food safety and security across Italy. CI - Copyright (c) 2025 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Devecchi, Andrea AU - Devecchi A AD - University of Gastronomic Sciences, Pollenzo, Italy; Department of Medical Sciences, University of Turin, Turin, Italy. FAU - Stacchini, Lorenzo AU - Stacchini L AD - Department of Community Healthcare Network, Health District "Toscana ASL Nord Ovest", Pisa, Italy. FAU - Nucci, Daniele AU - Nucci D AD - Struttura Semplice Dipartimentale Igiene Alimenti e Nutrizione, Dipartimento di Igiene e Prevenzione Sanitaria, Agenzia di Tutela della Salute (ATS) Brescia, Brescia, Italy; PhD National Program in One Health Approaches to Infectious Diseases and Life Science Research Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy. FAU - Ferrando, Maria Regina AU - Ferrando MR AD - Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy. FAU - Proietti, Elisa AU - Proietti E AD - Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy. FAU - Moretton, Martina AU - Moretton M AD - Research and Innovation Center, Fondazione Edmund Mach, San Michele all'Adige, Italy; OnFoods - Research and Innovation Network on Food and Nutrition Sustainability, Safety and Security - Working on Foods, Parma, Italy. FAU - Formisano, Elena AU - Formisano E AD - Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy; Dietetics and Clinical Nutrition Unit, IRCCS Policlinic Hospital San Martino, Genoa, Italy. FAU - Leone, Alessandro AU - Leone A AD - International Center for the Assessment of Nutritional Status and the development of Dietary Intervention Strategies (ICANS-DIS), Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Milan, Italy; IRCCS Istituto Auxologico Italiano, Clinical Nutrition Unit, Department of Endocrine and Metabolic Medicine, Milan, Italy. FAU - Gianfredi, Vincenza AU - Gianfredi V AD - Department of Biomedical Sciences for Health, University of Milan, Milan, Italy. Electronic address: vincenza.gianfredi@unimi.it. LA - eng PT - Journal Article DEP - 20251003 PL - United States TA - Nutrition JT - Nutrition (Burbank, Los Angeles County, Calif.) JID - 8802712 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Italy MH - Male MH - Adult MH - *Food Safety MH - Middle Aged MH - *Health Knowledge, Attitudes, Practice MH - *Food Security/statistics & numerical data MH - Surveys and Questionnaires MH - Young Adult MH - Adolescent OTO - NOTNLM OT - Cross sectional OT - Food safety OT - Food security OT - Italy OT - Regional disparities COIS- Declaration of competing interest All authors have nothing to declare. EDAT- 2025/11/01 05:37 MHDA- 2025/12/09 00:31 CRDT- 2025/10/31 19:07 PHST- 2025/02/14 00:00 [received] PHST- 2025/08/29 00:00 [revised] PHST- 2025/09/30 00:00 [accepted] PHST- 2025/12/09 00:31 [medline] PHST- 2025/11/01 05:37 [pubmed] PHST- 2025/10/31 19:07 [entrez] AID - S0899-9007(25)00303-X [pii] AID - 10.1016/j.nut.2025.112985 [doi] PST - ppublish SO - Nutrition. 2026 Feb;142:112985. doi: 10.1016/j.nut.2025.112985. Epub 2025 Oct 3. PMID- 41170824 OWN - NLM STAT- MEDLINE DCOM- 20251204 LR - 20260921 IS - 1460-2350 (Electronic) IS - 0268-1161 (Print) IS - 0268-1161 (Linking) VI - 40 IP - 12 DP - 2025 Dec 1 TI - Identification of potential NAD-related biomarkers of recurrent miscarriage risk. PG - 2247-2259 LID - 10.1093/humrep/deaf195 [doi] AB - STUDY QUESTION: Do women with a history of recurrent miscarriage have altered nicotinamide adenine dinucleotide (NAD)-related metabolites that can be detected in blood, plasma, or urine samples? SUMMARY ANSWER: Women with a history of recurrent miscarriage have higher blood, plasma, and urine concentrations of NAD Salvage Pathway excretion products, and urinary excretion of nicotinamide (NAM) is also elevated, compared to control women. WHAT IS KNOWN ALREADY: Recurrent miscarriage risk is associated with advancing age, high and low BMI, dietary factors, various medical conditions including inflammation, as well as environmental exposures, e.g. to chemicals and pollution. Perturbation of NAD synthesis due to genetic and/or environmental factors causes NAD deficiency, which is implicated in Congenital NAD Deficiency Disorder (CNDD) characterized by recurrent pregnancy loss and congenital anomalies. In CNDD mouse models, foetal anomalies and embryo loss are prevented if NAD levels are raised by supplementing the mother's diet with an NAD precursor, such as vitamin B3, during pregnancy. STUDY DESIGN, SIZE, DURATION: This prospective pilot cohort study included 88 non-pregnant women between 20 and 40 years of age, 37 with and 51 without a history of recurrent miscarriage. Recurrent miscarriage was defined as a history of two or more consecutive spontaneous miscarriages <20 weeks' gestation, with the last miscarriage between 6 weeks and 2 years prior to recruitment. The study was conducted at the Royal Hospital for Women, Sydney, Australia, between March 2022 and December 2023. PARTICIPANTS/MATERIALS, SETTING, METHODS: Participants completed a questionnaire about their socio-demographic characteristics, health, lifestyle, diet, medication, and vitamin use; and provided morning fasting blood and urine samples. Levels of NAD and 25 related metabolites were measured in whole blood, plasma, and urine using a validated ultra-high performance liquid chromatography-tandem mass spectrometry method. Differences in NAD metabolism between the groups were assessed by volcano plots and partial least-squares discriminant analysis. Characteristics of women between the two groups were compared using chi-squared statistics. Multivariable generalized additive models were used to assess the association between NAD metabolites and miscarriage. Predictive accuracy of metabolites alone and with age was examined using three machine learning models, including Logistic Regression, Random Forest, and Gradient Boosting Classifier and assessed using the area under the receiver operating characteristic curve (AUROC). MAIN RESULTS AND THE ROLE OF CHANCE: Elevated levels of the metabolites 1-methylnicotinamide (1MNA), N-methyl-2-pyridone-5-carboxamide (2PY), and N-methyl-4-pyridone-3-carboxamide (4PY), representing excretion metabolites of the NAD Salvage Pathway, were associated with a higher risk of recurrent miscarriage. These metabolites showed a strong positive correlation among the three tested biological matrices, confirming the suitability of all three matrices to quantify these markers. Whole blood anthranilic acid and urine NAM levels were also elevated in women with recurrent miscarriage. 1MNA in plasma was associated with recurrent miscarriage on univariate analysis, with the effect sustained after taking into account maternal age (adjusted odds ratio 1.02; 95% CI 1.01, 1.03) with every one-unit increase in 1MNA, the odds of miscarriage increasing by 2%. The predictive accuracy using machine learning approaches was highest when all three metabolites 1MNA, 2PY, and 4PY, and age were included in the model (AUROC 0.89; 95% CI 0.83, 0.95). LIMITATIONS, REASONS FOR CAUTION: This study was conducted in a single hospital, which assures high internal validity but may limit external validity. Sample size was small, and findings should be replicated in larger studies. The measured levels of NAD-related metabolites represent a snapshot at the time of sample collection but might not be reflective of when the women had been pregnant. WIDER IMPLICATIONS OF THE FINDINGS: Our novel finding of elevated excretion of NAM and its derived products in women experiencing recurrent miscarriage suggests differences in the NAD synthesis pathway are linked to adverse pregnancy outcomes. The significant differences in 2PY and 4PY levels in the circulation and urine between the study groups indicate that these metabolites are potential biomarkers associated with recurrent miscarriage. Several conditions which are associated with adverse pregnancy outcomes also affect NAD metabolism and cause elevated levels of these metabolites. Thus, these metabolites may not simply be biomarkers but also be an indicator of the underlying mechanisms in many cases of recurrent miscarriage. Further evaluation of NAD metabolism in women with recurrent miscarriage in other populations and of other associations including diet is required. STUDY FUNDING/COMPETING INTEREST(S): This research was supported by funds to S.L.D. from: the National Health and Medical Research Council (NHMRC), Principal Research Fellowship (ID1135886), Leadership Level 3 Fellowship (ID2007896), and Project Grant (ID1162878); a New South Wales (NSW) Health Cardiovascular Research Capacity Program Senior Researcher Grant; philanthropic support from The Key Foundation, The Ross Trust, and Steven and Linda Harker. N.N. was supported by NHMRC Leadership Level 1 Fellowship (ID1197940) and Financial Markets Foundation for Children. We gratefully acknowledge the Victor Chang Cardiac Research Institute Innovation Centre, funded by the NSW Government, as well as funding from the Freedman Foundation for the Metabolomics Facility. The authors declare no conflicts of interest. TRIAL REGISTRATION NUMBER: N/A. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. FAU - Cuny, Hartmut AU - Cuny H AUID- ORCID: 0000-0002-1551-2354 AD - Victor Chang Cardiac Research Institute, Sydney, NSW, Australia. AD - School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia. FAU - Shand, Antonia W AU - Shand AW AUID- ORCID: 0000-0002-4200-9295 AD - Children's Hospital at Westmead Clinical School, University of Sydney, Sydney, NSW, Australia. AD - Department of Maternal Fetal Medicine, Royal Hospital for Women, Sydney, NSW, Australia. AD - Leeder Centre for Health Policy, Economics and Data, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia. FAU - Goth, Jennifer AU - Goth J AUID- ORCID: 0000-0002-5174-0928 AD - Department of Maternal Fetal Medicine, Royal Hospital for Women, Sydney, NSW, Australia. FAU - Sheng, Delicia Z AU - Sheng DZ AUID- ORCID: 0000-0002-2658-7386 AD - Victor Chang Cardiac Research Institute, Sydney, NSW, Australia. AD - University of New South Wales, Sydney, NSW, Australia. FAU - Tossey, Tamarah AU - Tossey T AD - Department of Maternal Fetal Medicine, Royal Hospital for Women, Sydney, NSW, Australia. FAU - Martin, Ella M M A AU - Martin EMMA AUID- ORCID: 0000-0001-9511-9175 AD - Victor Chang Cardiac Research Institute, Sydney, NSW, Australia. FAU - Sipka, Alena AU - Sipka A AUID- ORCID: 0009-0008-1948-6537 AD - Victor Chang Cardiac Research Institute, Sydney, NSW, Australia. FAU - Aleshin, Olga AU - Aleshin O AUID- ORCID: 0000-0001-7133-5367 AD - Department of Maternal Fetal Medicine, Royal Hospital for Women, Sydney, NSW, Australia. FAU - Schneuer, Francisco J AU - Schneuer FJ AUID- ORCID: 0000-0002-6245-7159 AD - Children's Hospital at Westmead Clinical School, University of Sydney, Sydney, NSW, Australia. AD - Leeder Centre for Health Policy, Economics and Data, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia. FAU - Nassar, Natasha AU - Nassar N AUID- ORCID: 0000-0002-3720-9655 AD - Children's Hospital at Westmead Clinical School, University of Sydney, Sydney, NSW, Australia. AD - Leeder Centre for Health Policy, Economics and Data, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia. AD - Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia. FAU - Dunwoodie, Sally L AU - Dunwoodie SL AUID- ORCID: 0000-0002-2069-7349 AD - Victor Chang Cardiac Research Institute, Sydney, NSW, Australia. AD - School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia. LA - eng GR - National Health and Medical Research Council/ GR - ID1135886/Principal Research Fellowship/ GR - New South Wales/ GR - Key Foundation/ GR - Ross Trust/ GR - Steven and Linda Harker/ GR - NSW Government/ GR - Freedman Foundation for the Metabolomics Facility/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Hum Reprod JT - Human reproduction (Oxford, England) JID - 8701199 RN - 0 (Biomarkers) RN - 0U46U6E8UK (NAD) RN - 25X51I8RD4 (Niacinamide) SB - IM MH - Humans MH - Female MH - *Abortion, Habitual/blood/urine/metabolism MH - Adult MH - Biomarkers/blood/urine MH - Pregnancy MH - *NAD/blood/urine/metabolism MH - Prospective Studies MH - Pilot Projects MH - Young Adult MH - Niacinamide/urine/blood MH - Risk Factors PMC - PMC12675424 OTO - NOTNLM OT - NAD OT - embryo OT - metabolism OT - pregnancy loss OT - recurrent miscarriage OT - vitamin B3 COIS- The authors declare no conflict of interests. EDAT- 2025/10/31 17:32 MHDA- 2025/12/04 06:27 PMCR- 2025/10/31 CRDT- 2025/10/31 07:52 PHST- 2025/05/28 00:00 [received] PHST- 2025/09/15 00:00 [revised] PHST- 2025/12/04 06:27 [medline] PHST- 2025/10/31 17:32 [pubmed] PHST- 2025/10/31 07:52 [entrez] PHST- 2025/10/31 00:00 [pmc-release] AID - 8307317 [pii] AID - deaf195 [pii] AID - 10.1093/humrep/deaf195 [doi] PST - ppublish SO - Hum Reprod. 2025 Dec 1;40(12):2247-2259. doi: 10.1093/humrep/deaf195. PMID- 41166607 OWN - NLM STAT- MEDLINE DCOM- 20251030 LR - 20260922 IS - 2368-7959 (Electronic) IS - 2368-7959 (Linking) VI - 12 DP - 2025 Oct 30 TI - Perceived Digital Well-Being Scale in the United States and United Kingdom: Psychometric Validation Study. PG - e78334 LID - 10.2196/78334 [doi] LID - e78334 AB - BACKGROUND: Digital well-being encourages balanced mobile use. The Perceived Digital Well-Being in Adolescence Scale measures this in adolescents but has been validated only in Slovenia, raising questions about its relevance for other age groups and cultural contexts. OBJECTIVE: This study had three primary objectives: (1) confirm the 3-factor structure of an English version of the Perceived Digital Well-Being in Adolescence Scale, renamed the Perceived Digital Well-Being Scale (PDWS), in samples of young adults from the United States and the United Kingdom; (2) examine the associations between PDWS dimensions and participants' sociodemographic characteristics; and (3) explore the relationships between PDWS scores and patterns of smartphone use. METHODS: A total of 1854 young adults from the United States and the United Kingdom (ages 18-25 years; mean 22.4, SD 2.1; 892, 48.1% female, 872, 47.0% male, 90, 4.9% nonbinary) participated in an online survey including the PDWS, digital flourishing, and digital stress measures. Data were analyzed using descriptive statistics, confirmatory factor analysis, correlations, t tests, chi-squared tests, and moderation-mediation analysis. RESULTS: Smartphone screen time and smartphone time for nonessential activities were statistically higher in the US sample than in the UK sample (mean 6.95 vs mean 6.13; t1852=4.97; P<.001; d=0.27 and mean 3.62 vs mean 3.29; t1852=5.57; P<.001; d=0.25, respectively). The digital well-being total score was statistically higher among US participants when compared with the UK counterparts (mean 3.49 vs mean 3.38; t1852=3.33; P<.001; d=0.15). Male participants were significantly more represented among the group with higher PDWB scores (chi2136=478.45; P<.001). Confirmatory factor analysis supported the adequacy of the 3-factor model (emotional, social, and cognitive), indicating strong model fit (critical indices >/=0.90). Evidence of convergent validity was established through significant associations between PDWS scores and measures of digital flourishing and digital stress (most correlation coefficients being significant at P<.001). Measurement invariance testing confirmed the scale's equivalence across US and UK samples (chi2246 change=17.90; P=.21); however, strict invariance across gender (male vs female) was not supported (chi2246 change=200.91; P<.001). Gender, sexual orientation, relationship status, ethnicity, socioeconomic status, and education level significantly influenced PDWS scores. Gender and socioeconomic status also moderated the relationship between smartphone use or screen time and PDWS scores (b=0.048; P=.03 and b=0.020; P=.03, respectively), indicating that these factors affect how smartphone usage relates to psychological distress or well-being in different demographic groups. CONCLUSIONS: The PDWS showed good psychometric properties in the US and UK samples. The scale offers a promising tool for identifying individuals at risk of adverse outcomes associated with digital connectivity. CI - (c)Germano Vera Cruz, Magdalena Liberacka-Dwojak, Monika Wilkosc-Debczynska, Merve Aktas Terzioglu, Todd Farchione, Tania Lecomte, Sandy Ingram, Riaz Khan, Yasser Khazaal. Originally published in JMIR Mental Health (https://mental.jmir.org). FAU - Vera Cruz, Germano AU - Vera Cruz G AUID- ORCID: 0000-0002-8297-6933 AD - Department of Psychology, Universite de Picardie Jules Verne, Amiens, France. FAU - Liberacka-Dwojak, Magdalena AU - Liberacka-Dwojak M AUID- ORCID: 0000-0001-8092-4219 AD - Department of Health Psychology, Faculty of Psychology, Kazimierz Wielki University, Bydgoszcz, Poland. FAU - Wilkosc-Debczynska, Monika AU - Wilkosc-Debczynska M AUID- ORCID: 0000-0002-0094-7793 AD - Department of Health Psychology, Faculty of Psychology, Kazimierz Wielki University, Bydgoszcz, Poland. FAU - Aktas Terzioglu, Merve AU - Aktas Terzioglu M AUID- ORCID: 0000-0002-7668-8222 AD - Department of Child and Adolescent Psychiatry, Faculty of Medicine, Pamukkale University, Denizli, Turkey. FAU - Farchione, Todd AU - Farchione T AUID- ORCID: 0000-0002-6494-6829 AD - Department of Psychology, University of Boston, Boston, MA, United States. FAU - Lecomte, Tania AU - Lecomte T AUID- ORCID: 0000-0002-0340-3759 AD - Department of Psychology, Universite de Montreal, Montreal, Canada. FAU - Ingram, Sandy AU - Ingram S AUID- ORCID: 0000-0002-4050-580X AD - Institute for Intelligent and Secure Systems, School of Engineering and Architecture, University of Applied Sciences of Western Switzerland, Fribourg, Switzerland. FAU - Khan, Riaz AU - Khan R AUID- ORCID: 0000-0002-4520-7465 AD - Department of Psychiatry, Frontier Medical College, Bahria University, Islamabad, Pakistan. FAU - Khazaal, Yasser AU - Khazaal Y AUID- ORCID: 0000-0002-8549-6599 AD - Department of Psychiatry, Addiction Medicine, Lausanne University Hospital and Lausanne University, Rue du Bugnon 23, Lausanne, 1011, Switzerland, 41 766792018. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20251030 PL - Canada TA - JMIR Ment Health JT - JMIR mental health JID - 101658926 SB - IM MH - Humans MH - United Kingdom MH - Male MH - Female MH - United States MH - Young Adult MH - Adult MH - Adolescent MH - *Psychometrics MH - *Smartphone/statistics & numerical data MH - Surveys and Questionnaires MH - Reproducibility of Results PMC - PMC12574938 OTO - NOTNLM OT - Perceived Digital Well-Being Scale OT - digital connectivity OT - digital flourishing OT - digital stress OT - digital well-being OT - smartphone OT - social media COIS- Conflicts of Interest: TF reports receiving royalties from Oxford University Press. Grant funding for various research projects has been provided by the National Institute of Mental Health, the John Templeton Foundation, the Juvenile Diabetes Research Foundation, and the National Institute on Alcohol Abuse and Alcoholism. Over the past several years, TF has received consulting fees and honoraria from the Nevada System of Higher Education, the National Center of Neurology and Psychiatry in Japan, Brightside Health, TAGE S.L., Grupo Pacifico, Kaiser Permanente, and Allegheny Health Network. EDAT- 2025/10/30 18:26 MHDA- 2025/10/30 18:27 PMCR- 2025/10/30 CRDT- 2025/10/30 15:13 PHST- 2025/05/31 00:00 [received] PHST- 2025/09/25 00:00 [revised] PHST- 2025/09/26 00:00 [accepted] PHST- 2025/10/30 18:27 [medline] PHST- 2025/10/30 18:26 [pubmed] PHST- 2025/10/30 15:13 [entrez] PHST- 2025/10/30 00:00 [pmc-release] AID - v12i1e78334 [pii] AID - 78334 [pii] AID - 10.2196/78334 [doi] PST - epublish SO - JMIR Ment Health. 2025 Oct 30;12:e78334. doi: 10.2196/78334. PMID- 41166547 OWN - NLM STAT- Publisher LR - 20251210 IS - 1663-2826 (Electronic) IS - 1663-2818 (Linking) DP - 2025 Oct 30 TI - Validity and Discriminative Value of Activity Questionnaires in Youth with Type 1 Diabetes. PG - 1-10 LID - 10.1159/000549282 [doi] AB - INTRODUCTION: Prospective data quantifying physical activity (PA) levels in Australian youth with type 1 diabetes (T1D) are lacking. Structured questionnaire instruments may provide useful information, but have not been evaluated in youth with T1D. The objective of this study was to evaluate the validity of three paediatric PA questionnaires in young people with T1D and their ability to differentiate those not meeting PA guidelines of 60 min of moderate-to-vigorous PA (MVPA) per day from those who do. METHODS: Eighty youth with T1D (42 boys, 38 girls; age: 13.1 +/- 2.6 years; body mass index: 20.2 +/- 3.9 kg.m-2; glycosylated haemoglobin: 58.5 +/- 10.1 mmol/mol; T1D duration: 5.4 +/- 3.1 years) wore an Actigraph GT3x accelerometer for 7 days and on day 8 completed three self-report PA instruments: (i) the Physical Activity Questionnaire (PAQ), (ii) Previous Day Physical Activity Recall (PDPAR), and (iii) a Single-Item Physical Activity Scale (SIPAS). Validity coefficients for each instrument using accelerometry-derived MVPA minutes were determined using Spearman's correlation coefficient. Receiver operator characteristic (ROC) curves were generated and optimal cut-points determined. RESULTS: Mean daily MVPA minutes were 46.6 +/- 25.5 min; 21/80 participants (26%) achieved an average of >/=60 MVPA minutes per day. The PAQ had the highest validity coefficient (r = 0.53; p < 0.001), followed by the single-item tool (r = 0.39; p < 0.001) and PDPAR (r = 0.09; p = 0.4). Area under the ROC curve was 0.7, 0.5, and 0.7 for the PAQ, PDPAR, and single-item tools, respectively. Optimal cut-points for sensitivity and specificity were (i) a PAQ composite score of 2.8 (66.1% and 66.7%), (ii) 75 MVPA minutes on the PDPAR (59.3% and 47.6%), and (iii) 4.5 days on the SIPAS (71.2% and 38.1%). CONCLUSION: The PAQ has moderate-to-high criterion validity and showed moderate ability to discriminate between T1D youth meeting PA guidelines from those who do not. The single-item question had low-to-moderate construct validity, while the PDPAR did not correlate with objectively measured PA levels. The feasibility of incorporating the PAQ into clinical care for youth with T1D warrants further evaluation. CI - (c) 2025 S. Karger AG, Basel. FAU - Teo, Shaun Y M AU - Teo SYM AD - Rio Tinto Children's Diabetes Centre, Kids Research Institute, Perth, Washington, Australia. AD - Centre for Child Health Research, The University of Western Australia, Perth, Washington, Australia. AD - School of Allied Health (Exercise Science), Murdoch University, Perth, Washington, Australia. FAU - Lim, Rachel J AU - Lim RJ AD - Rio Tinto Children's Diabetes Centre, Kids Research Institute, Perth, Washington, Australia. FAU - Smith, Grant J AU - Smith GJ AD - Rio Tinto Children's Diabetes Centre, Kids Research Institute, Perth, Washington, Australia. FAU - Shetty, Vinutha B AU - Shetty VB AD - Rio Tinto Children's Diabetes Centre, Kids Research Institute, Perth, Washington, Australia. AD - Centre for Child Health Research, The University of Western Australia, Perth, Washington, Australia. AD - Department of Endocrinology and Diabetes, Perth Children's Hospital, Perth, Washington, Australia. FAU - Jones, Timothy W AU - Jones TW AD - Rio Tinto Children's Diabetes Centre, Kids Research Institute, Perth, Washington, Australia. AD - Centre for Child Health Research, The University of Western Australia, Perth, Washington, Australia. AD - Department of Endocrinology and Diabetes, Perth Children's Hospital, Perth, Washington, Australia. FAU - Davis, Elizabeth A AU - Davis EA AD - Rio Tinto Children's Diabetes Centre, Kids Research Institute, Perth, Washington, Australia. AD - Centre for Child Health Research, The University of Western Australia, Perth, Washington, Australia. AD - Department of Endocrinology and Diabetes, Perth Children's Hospital, Perth, Washington, Australia. FAU - Taplin, Craig E AU - Taplin CE AD - Rio Tinto Children's Diabetes Centre, Kids Research Institute, Perth, Washington, Australia, craig.taplin@health.wa.gov.au. AD - Centre for Child Health Research, The University of Western Australia, Perth, Washington, Australia, craig.taplin@health.wa.gov.au. AD - Department of Endocrinology and Diabetes, Perth Children's Hospital, Perth, Washington, Australia, craig.taplin@health.wa.gov.au. LA - eng PT - Journal Article DEP - 20251030 PL - Switzerland TA - Horm Res Paediatr JT - Hormone research in paediatrics JID - 101525157 SB - IM OTO - NOTNLM OT - Accelerometry OT - Physical activity OT - Questionnaires OT - Type 1 diabetes OT - Validation OT - Youth EDAT- 2025/10/30 18:26 MHDA- 2025/10/30 18:26 CRDT- 2025/10/30 14:24 PHST- 2025/05/29 00:00 [received] PHST- 2025/10/16 00:00 [accepted] PHST- 2025/10/30 18:26 [pubmed] PHST- 2025/10/30 18:26 [medline] PHST- 2025/10/30 14:24 [entrez] AID - 000549282 [pii] AID - 10.1159/000549282 [doi] PST - aheadofprint SO - Horm Res Paediatr. 2025 Oct 30:1-10. doi: 10.1159/000549282. PMID- 41166313 OWN - NLM STAT- MEDLINE DCOM- 20251030 LR - 20260129 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 10 DP - 2025 TI - Predicting hypertension and identifying most important factors among married women in Bangladesh using machine learning approach. PG - e0335442 LID - 10.1371/journal.pone.0335442 [doi] LID - e0335442 AB - INTRODUCTION: Hypertension is a leading contributor to maternal and cardiometabolic morbidity in Bangladesh. We developed and interpreted machine-learning (ML) models to predict hypertension and rank associated factors among married women with the goal of informing targeted screening and policy in low-resource settings. METHODS: We analyzed 4,253 married women from the nationally representative BDHS 2017-18 survey (hypertension prevalence: 23.1%). Twelve ML algorithms were trained under six class-balancing strategies with hyperparameters tuned via random search. Validation used a hold-out test set (80/20) and repeated stratified k-fold cross-validation; bootstrap confidence intervals were estimated for the selected model. Model performance was compared with parametric and non-parametric tests. To interpret results, SHAP was used to rank the top 20 predictors and visualize feature effects. Models quantify associations rather than causation. RESULTS: The Extra Trees classifier with SMOTE+ENN achieved the best discrimination (F1 = 0.94; AUC-PR = 0.95; ROC-AUC = 0.95). Compared with the original imbalanced training, minority-class detection improved substantially (Extra Trees F1 increased from 0.08 to 0.94; recall from 0.04 to 0.95) while accuracy and ROC-AUC remained relatively stable across samplers. Statistical testing favored SMOTE+ENN for recall, F1, G-mean and AUC-PR. SHAP identified age, parity, recent births, contraceptive use, spousal education and BMI as key predictors. Younger age (<35 years) and normal/underweight status were protective, while parity >/=2-3, husbands' age >/= 40 years and overweight/obesity increased risk. CONCLUSIONS: An interpretable ensemble model built primarily on sociodemographic and behavioral variables supplemented by limited biometric markers (BMI, glucose) can accurately flag hypertensive risk among married women in Bangladesh. Findings support programmatic integration of risk scores into eRegistries, routine blood pressure checks in family planning and postpartum visits, husband-focused education/SMS interventions and prioritization of high-parity households in high-risk regions. External validation on BDHS-2022 is planned to assess generalizability. CI - Copyright: (c) 2025 Das et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Das, Novel Chandra AU - Das NC AUID- ORCID: 0000-0002-6038-2130 AD - International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. FAU - Ghosh, Probir Kumar AU - Ghosh PK AD - International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. FAU - Hossain, Md Alamgir AU - Hossain MA AUID- ORCID: 0000-0003-4514-1934 AD - International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. FAU - Shuvo, Uddip Acharjee AU - Shuvo UA AD - Institute of information technology, University of Dhaka, Dhaka, Bangladesh. FAU - Talukder, Nipa Rani AU - Talukder NR AD - Department of Computer Science and Engineering, North East University, Dhaka, Bangladesh. FAU - Khatun, Fatema AU - Khatun F AD - International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. FAU - Chowdhury, Mohammad Ziaul Islam AU - Chowdhury MZI AD - Department of Psychiatry, University of Calgary, Hospital Drive NW, Calgary, Canada. AD - Provincial Research Data Services, Alberta Health Services, Alberta, Canada. AD - Department of General Educational Development, Daffodil International University, Dhaka, Bangladesh. LA - eng PT - Journal Article DEP - 20251030 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM EIN - PLoS One. 2026 Jan 9;21(1):e0340871. doi: 10.1371/journal.pone.0340871. PMID: 41511920 EIN - PLoS One. 2026 Jan 29;21(1):e0342021. doi: 10.1371/journal.pone.0342021. PMID: 41610068 MH - Humans MH - Female MH - Bangladesh/epidemiology MH - *Machine Learning MH - Adult MH - *Hypertension/epidemiology/diagnosis MH - Middle Aged MH - Risk Factors MH - Young Adult MH - Marriage MH - Prevalence MH - Adolescent PMC - PMC12574887 COIS- The authors have declared that no competing interests exist. EDAT- 2025/10/30 18:26 MHDA- 2025/10/30 18:27 PMCR- 2025/10/30 CRDT- 2025/10/30 13:42 PHST- 2025/02/08 00:00 [received] PHST- 2025/10/10 00:00 [accepted] PHST- 2025/10/30 18:27 [medline] PHST- 2025/10/30 18:26 [pubmed] PHST- 2025/10/30 13:42 [entrez] PHST- 2025/10/30 00:00 [pmc-release] AID - PONE-D-25-05724 [pii] AID - 10.1371/journal.pone.0335442 [doi] PST - epublish SO - PLoS One. 2025 Oct 30;20(10):e0335442. doi: 10.1371/journal.pone.0335442. eCollection 2025. PMID- 41165850 OWN - NLM STAT- MEDLINE DCOM- 20251030 LR - 20260917 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 184 IP - 11 DP - 2025 Oct 30 TI - Associations of maternal dietary carbohydrate intake, glycemic index, and glycemic load during pregnancy with offspring neurodevelopment. PG - 721 LID - 10.1007/s00431-025-06519-5 [doi] LID - 721 AB - Emerging evidence suggests that periconceptional nutrition could significantly impact children's brain development. Few studies have explored the effect of maternal carbohydrate intake on offspring's cognitive outcomes. Evidence suggests poor glycemic control during pregnancy may impair neurodevelopment. Optimizing maternal carbohydrate intake during pregnancy by focusing on low to moderate glycemic index (GI) and glycemic load (GL) foods may reduce these risks. This study aimed to evaluate the associations between maternal carbohydrate intake, dietary GI, and GL during first and third trimesters of pregnancy and children's neurodevelopment in the early postnatal period and preschool years. The study included 420 mother-child pairs from the ECLIPSES cohort. Maternal carbohydrate intake, GI, and GL were assessed using a validated food frequency questionnaire during the first and third trimesters. Children's neurodevelopment was assessed at 40 days of age using the Bayley Scales of Infant Development and at 4 years using the Wechsler Preschool and Primary Scale of Intelligence and the Developmental Neuropsychological Assessment. Multivariable linear and logistic regression analyses were conducted. Maternal carbohydrate intake, GI, and GL were negatively associated with expressive language development in the early postnatal period (P < 0.05). Children of mothers in the highest GL tertile during early pregnancy showed lower motor development at 40 days (beta coefficient [95% CI] = -3.517 [-6.898, -0.135], P-trend 0.041). Higher maternal carbohydrate consumption and GL throughout pregnancy were linked to lower processing speed, intelligence quotient, nonverbal skills, and visuomotor precision at preschool age (all P-trend < 0.05). CONCLUSION: The quantity and quality of maternal carbohydrate intake, particularly GL, influence children's neurodevelopment, including language, motor skills, processing speed, nonverbal abilities, overall intellectual functions, and visuomotor precision, highlighting the need for more refined dietary recommendations during pregnancy. WHAT IS KNOWN: * Maternal nutrition plays a critical role in shaping children''s brain health. * Poor maternal glycemic control has been linked to adverse neurodevelopmental outcomes, but the specific impact of maternal carbohydrate quantity and quality remains unclear. WHAT IS NEW: * The quantity and quality of maternal carbohydrate intake influence children''s neurodevelopment in early life. * These findings support the need for tailored dietary recommendations during pregnancy focusing on carbohydrate quantity and quality to optimize neurodevelopmental outcomes. CI - (c) 2025. The Author(s). FAU - Mateu-Fabregat, Javier AU - Mateu-Fabregat J AD - Nutrition and Metabolic Health Research Group (NuMeH), Department of Biochemistry and Biotechnology, Universitat Rovira I Virgili (URV), Reus, Spain. AD - Center of Environmental, Food and Toxicological Technology (TecnATox), Universitat Rovira I Virgili (URV), Reus, Spain. AD - Institute of Health Pere Virgili (IISPV), Reus, Spain. FAU - Canals, Josefa AU - Canals J AD - Institute of Health Pere Virgili (IISPV), Reus, Spain. AD - Nutrition and Mental Health Research Group (NUTRISAM), Universitat Rovira I Virgili (URV), Reus, Spain. AD - Research Center for Behavior Assessment (CRAMC), Departament of Psychology, Universitat Rovira I Virgili (URV), Tarragona, Spain. FAU - Jardi, Cristina AU - Jardi C AD - Institute of Health Pere Virgili (IISPV), Reus, Spain. AD - Nutrition and Mental Health Research Group (NUTRISAM), Universitat Rovira I Virgili (URV), Reus, Spain. FAU - Hernandez-Martinez, Carmen AU - Hernandez-Martinez C AD - Institute of Health Pere Virgili (IISPV), Reus, Spain. AD - Nutrition and Mental Health Research Group (NUTRISAM), Universitat Rovira I Virgili (URV), Reus, Spain. AD - Research Center for Behavior Assessment (CRAMC), Departament of Psychology, Universitat Rovira I Virgili (URV), Tarragona, Spain. FAU - Voltas, Nuria AU - Voltas N AD - Institute of Health Pere Virgili (IISPV), Reus, Spain. AD - Nutrition and Mental Health Research Group (NUTRISAM), Universitat Rovira I Virgili (URV), Reus, Spain. AD - Research Center for Behavior Assessment (CRAMC), Departament of Psychology, Universitat Rovira I Virgili (URV), Tarragona, Spain. AD - Serra Hunter Fellow, Department of Psychology, Universitat Rovira I Virgili (URV), Tarragona, Spain. FAU - Bullo, Monica AU - Bullo M AD - Nutrition and Metabolic Health Research Group (NuMeH), Department of Biochemistry and Biotechnology, Universitat Rovira I Virgili (URV), Reus, Spain. monica.bullo@urv.cat. AD - Center of Environmental, Food and Toxicological Technology (TecnATox), Universitat Rovira I Virgili (URV), Reus, Spain. monica.bullo@urv.cat. AD - Institute of Health Pere Virgili (IISPV), Reus, Spain. monica.bullo@urv.cat. AD - CIBER Physiology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, Madrid, Spain. monica.bullo@urv.cat. FAU - Arija, Victoria AU - Arija V AD - Institute of Health Pere Virgili (IISPV), Reus, Spain. victoria.arija@urv.cat. AD - Nutrition and Mental Health Research Group (NUTRISAM), Universitat Rovira I Virgili (URV), Reus, Spain. victoria.arija@urv.cat. LA - eng GR - 2023 FISDU 00387/Agencia de Gestio d'Ajuts Universitaris i de Recerca/ PT - Journal Article DEP - 20251030 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 0 (Dietary Carbohydrates) SB - IM MH - Humans MH - Pregnancy MH - Female MH - *Glycemic Index MH - *Glycemic Load MH - *Dietary Carbohydrates/administration & dosage MH - Child, Preschool MH - *Child Development MH - Male MH - Infant MH - *Prenatal Exposure Delayed Effects/etiology MH - Adult MH - *Maternal Nutritional Physiological Phenomena MH - Infant, Newborn MH - Neurodevelopmental Disorders/etiology PMC - PMC12575505 OTO - NOTNLM OT - Carbohydrates OT - Glycemic index OT - Glycemic load OT - Neurodevelopment OT - Pregnancy COIS- Declarations. Ethics approval: The ECLIPSES study was registered at www.clinicaltrialsregister.eu under EudraCT number 2012-005480-28. The study was conducted in accordance with the ethical standards of the Declaration of Helsinki and received approval from the Clinical Research Ethics Committee of the Jordi Gol University Institute for Primary Care Research, the Pere Virgili Health Research Institute (IISPV), and the Spanish Agency for Medicines and Medical Devices (AEMPS). Consent to participate: All participants provided written informed consent to participate in the study. Competing interests: The authors declare no competing interests. EDAT- 2025/10/30 18:26 MHDA- 2025/10/30 18:27 PMCR- 2025/10/30 CRDT- 2025/10/30 12:16 PHST- 2025/07/31 00:00 [received] PHST- 2025/09/24 00:00 [accepted] PHST- 2025/09/15 00:00 [revised] PHST- 2025/10/30 18:27 [medline] PHST- 2025/10/30 18:26 [pubmed] PHST- 2025/10/30 12:16 [entrez] PHST- 2025/10/30 00:00 [pmc-release] AID - 10.1007/s00431-025-06519-5 [pii] AID - 6519 [pii] AID - 10.1007/s00431-025-06519-5 [doi] PST - epublish SO - Eur J Pediatr. 2025 Oct 30;184(11):721. doi: 10.1007/s00431-025-06519-5. PMID- 41165187 OWN - NLM STAT- MEDLINE DCOM- 20251030 LR - 20251030 IS - 1210-7778 (Print) IS - 1210-7778 (Linking) VI - 33 IP - 3 DP - 2025 Sep TI - Validation of the Greek version of the International Physical Activity Questionnaire - Short Form in adults 18-65 years old. PG - 225-229 LID - 10.21101/cejph.a8446 [doi] AB - OBJECTIVES: Various tools and methods have been proposed to measure physical activity, with the International Physical Activity Questionnaire (IPAQ) being one of the most popular self-reported tools. The study's aim was to test the validity of IPAQ-SF among Greek male and female adults, aged 18-65 years. METHODS: A total of 134 adults (98 males) were randomly selected and participated in the study. The mean age of participants was 37.9 years (SD = 11.6), with 73.1% being male. Translation and back-translation was performed to ensure cultural adaptation. The validity of IPAQ-SF was ascertained using fitness measures (maximum oxygen uptake, VO2 max, velocity of VO2 max, maximum heart rate, and heartbeat at 1 min). RESULTS: Based on the IPAQ-SF, participants engaged in vigorous physical activity for an average of 3 days per week (mean = 68.8 minutes/day), moderate activity for 2.6 days per week (mean = 56.2 minutes/day), and walking for 3.7 days per week (mean = 24.4 minutes/day). The median total MET-minutes/week was 2,751. IPAQ-SF demonstrated moderate validity as modest positive correlations were observed between MET-minutes/week and VO2 max (rho = 0.3096, p < 0.001), and vVO2 max (rho = 0.2511, p = 0.008). IPAQ-SF demonstrated higher validity among females and individuals with BMI >/= 25 kg/m(2), with correlations reaching 0.5201 (p < 0.001) for VO2 max in participants with overweight/obesity. CONCLUSION: The present validation study suggests IPAQ-SF utility for monitoring physical activity levels in populations with overweight or obesity, while further refinement may be necessary to improve its applicability across all demographic groups. FAU - Dimitriadis, Nikos AU - Dimitriadis N AD - Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University of Athens, Athens, Greece. AD - Myathlete Exercise Physiology Hub, Glyfada, Greece. FAU - Partsafa, Maria AU - Partsafa M AD - Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University of Athens, Athens, Greece. FAU - Bokou, Nikoleta-Maria AU - Bokou NM AD - Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University of Athens, Athens, Greece. FAU - Dimitriadis, Alexandros AU - Dimitriadis A AD - Myathlete Exercise Physiology Hub, Glyfada, Greece. FAU - Taveira, Katy AU - Taveira K AD - Myathlete Exercise Physiology Hub, Glyfada, Greece. FAU - Panagiotakos, Demosthenes AU - Panagiotakos D AD - Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University of Athens, Athens, Greece. LA - eng PT - Journal Article PT - Validation Study PL - Czech Republic TA - Cent Eur J Public Health JT - Central European journal of public health JID - 9417324 SB - IM MH - Humans MH - Female MH - Adult MH - Male MH - Middle Aged MH - *Exercise MH - Greece MH - Surveys and Questionnaires/standards MH - Aged MH - Adolescent MH - Young Adult MH - Reproducibility of Results MH - Self Report OTO - NOTNLM OT - Greece OT - IPAQ OT - adults OT - physical activity OT - tools OT - validity EDAT- 2025/10/30 12:28 MHDA- 2025/10/30 12:29 CRDT- 2025/10/30 08:03 PHST- 2024/10/21 00:00 [received] PHST- 2025/09/25 00:00 [accepted] PHST- 2025/10/30 12:29 [medline] PHST- 2025/10/30 12:28 [pubmed] PHST- 2025/10/30 08:03 [entrez] AID - 10.21101/cejph.a8446 [doi] PST - ppublish SO - Cent Eur J Public Health. 2025 Sep;33(3):225-229. doi: 10.21101/cejph.a8446. PMID- 41164596 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251030 LR - 20251101 IS - 0976-4879 (Print) IS - 0975-7406 (Electronic) IS - 0975-7406 (Linking) VI - 17 IP - Suppl 3 DP - 2025 Sep TI - Effectiveness of Emotion-Focused Cognitive Behaviour Therapy on Emotional Hyporexia Among Adolescent Girls with Eating Problems: A Pilot Study. PG - S2563-S2565 LID - 10.4103/jpbs.jpbs_899_25 [doi] AB - BACKGROUND: Emotional hyporexia, a form of intentional food avoidance triggered by emotional distress, presents a growing health concern among adolescent girls. Addressing this behavior through psychological intervention is essential for preventing long-term health complications. AIM: This pilot study evaluated the effectiveness of Emotion-Focused Cognitive Behaviour Therapy (EFCBT) in reducing emotional hyporexia among adolescent girls experiencing eating-related problems. MATERIALS AND METHODS: A quasi-experimental design was adopted, involving 40 adolescent girls aged 16-18 years, equally divided into experimental (n = 20) and control (n = 20) groups. The experimental group received eight structured sessions of EFCBT focused on enhancing emotional regulation and promoting adaptive eating behaviors. Eating problems were initially screened using a modified version of the EAT-26 scale, and emotional hyporexia was assessed using a self-structured scale during both pre- and post-tests. RESULTS: Post-intervention analysis revealed a statistically significant reduction in emotional hyporexia scores within the experimental group (mean pre-test: 54.04 +/- 10.56; post-test: 22.2 +/- 3.58; P < 0.05). No significant changes were observed in the control group (P > 0.05), and no demographic factors were found to be associated with outcome variation. CONCLUSION: Emotion-Focused Cognitive Behaviour Therapy appears to be a promising intervention for reducing emotional hyporexia among adolescent girls. Further large-scale randomized controlled trials are recommended to validate these preliminary findings. CI - Copyright: (c) 2025 Journal of Pharmacy and Bioallied Sciences. FAU - Shinde, Sadhana Sudhir AU - Shinde SS AD - Department of Mental Health Nursing, Dr. D. Y. Patil College of Nursing, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. FAU - Naik, Nisha Sandeep AU - Naik NS AD - Department of Mental Health Nursing, Dr. D. Y. Patil College of Nursing, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. FAU - Adhyapak, Sadhana U AU - Adhyapak SU AD - Department of Medical Surgical Nursing, Dr. D. Y. Patil College of Nursing, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. FAU - Jamadar, Khurshid AU - Jamadar K AD - Department of Medical Surgical Nursing, Dr. D. Y. Patil College of Nursing, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. LA - eng PT - Journal Article DEP - 20250724 PL - India TA - J Pharm Bioallied Sci JT - Journal of pharmacy & bioallied sciences JID - 101537209 PMC - PMC12564058 OTO - NOTNLM OT - Adolescent girls OT - EFCBT OT - eating problems OT - emotion-focused cognitive behaviour therapy OT - emotional hyporexia OT - psychotherapy intervention COIS- There are no conflicts of interest. EDAT- 2025/10/30 06:29 MHDA- 2025/10/30 06:30 PMCR- 2025/09/01 CRDT- 2025/10/30 05:09 PHST- 2025/05/10 00:00 [received] PHST- 2025/06/12 00:00 [revised] PHST- 2025/06/13 00:00 [accepted] PHST- 2025/10/30 06:30 [medline] PHST- 2025/10/30 06:29 [pubmed] PHST- 2025/10/30 05:09 [entrez] PHST- 2025/09/01 00:00 [pmc-release] AID - JPBS-17-2563 [pii] AID - 10.4103/jpbs.jpbs_899_25 [doi] PST - ppublish SO - J Pharm Bioallied Sci. 2025 Sep;17(Suppl 3):S2563-S2565. doi: 10.4103/jpbs.jpbs_899_25. Epub 2025 Jul 24. PMID- 41163218 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260917 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 13 IP - 1 DP - 2025 Oct 29 TI - Development and preliminary validation of the Meat Consumption Scale. PG - 1193 LID - 10.1186/s40359-025-03270-2 [doi] LID - 1193 AB - BACKGROUND: The psychology of eating meat has emerged as a major field of study due to growing awareness of the negative impacts of excessive meat consumption on human and planetary health. Examining psychological profiles and testing strategies to address psychological barriers to meat reduction has become a prominent focus in psychology and various other disciplines. However, given the critical importance of psychometrically valid measurement tools in quantitative research, it is concerning that studies have largely relied on unvalidated, ad hoc survey instruments to measure meat consumption. To address this methodological gap this study aimed to develop and conduct an initial validation of a self-report questionnaire to measure an individual's meat consumption and meat-eating intentions. METHODS: The questionnaire was developed and evaluated through exploratory factor analysis (sample 1: N = 183 Australians) and confirmatory factor analysis (sample 2: N = 495 Australians). Construct validity was evaluated by confirming the scale's underlying factor structure and through correlations with demographic variables and ten theoretically related constructs. Internal consistency reliability was assessed with mean inter-item correlations, corrected total-item correlations, and coefficient H. RESULTS: Exploratory factor analysis did not identify a latent meat-eating intention scale, but did reveal a unidimensional latent factor representing total land-based meat consumption, which was named The Meat Consumption Scale (MCS). Confirmatory factor analysis verified the unidimensional structure of the MCS, with all model fit indices demonstrating excellent model fit. All correlations between the MCS and ten theoretically related constructs and demographic variables were significant and in the hypothesised directions, providing preliminary evidence of construct validity. Internal consistency reliability of the MCS was acceptable in both samples when evaluated by mean inter-item correlations and corrected item-total correlations, though coefficient H fell just shy of the recommended threshold. CONCLUSIONS: Findings provide preliminary evidence of reliability and construct validity of The Meat Consumption Scale (MCS), which is the first psychometrically evaluated tool designed to measure an individual's meat consumption using a fast (< 5 min) one-time assessment. This 12-item self-report questionnaire measures consumption of land-based meats-red meat (beef and lamb), poultry products, pork products, and other processed meats-over the past two-week period and is indicative of typical Western meat-eating patterns. The MCS is designed for cross-sectional and experimental research and applied contexts. Further validation of the scale, including assessment of criterion and discriminant validity and cross-cultural adaptations, is recommended. FAU - Camilleri, Lauren AU - Camilleri L AUID- ORCID: 0000-0001-5866-4844 AD - Institute for Health and Sport, Victoria University, Ballarat Rd, Footscray, Vic, 3011, Australia. lauren.camilleri@vu.edu.au. FAU - Jago, Andrew AU - Jago A AUID- ORCID: 0000-0002-0823-9927 AD - Institute for Health and Sport, Victoria University, Ballarat Rd, Footscray, Vic, 3011, Australia. FAU - Rehman, Abdul AU - Rehman A AD - Institute for Health and Sport, Victoria University, Ballarat Rd, Footscray, Vic, 3011, Australia. FAU - Gill, Peter Richard AU - Gill PR AUID- ORCID: 0000-0001-7772-4849 AD - Institute for Health and Sport, Victoria University, Ballarat Rd, Footscray, Vic, 3011, Australia. LA - eng PT - Journal Article PT - Validation Study DEP - 20251029 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Reproducibility of Results MH - *Psychometrics/instrumentation MH - Female MH - Adult MH - *Meat MH - Male MH - Surveys and Questionnaires/standards MH - Factor Analysis, Statistical MH - Australia MH - Middle Aged MH - Young Adult MH - *Feeding Behavior/psychology MH - Adolescent MH - Intention PMC - PMC12574032 OTO - NOTNLM OT - Dietary change OT - Intentions to reduce meat consumption OT - Measurement of meat consumption OT - Psychology of meat consumption OT - Psychometrics OT - Self-report questionnaire COIS- Declarations. Ethics approval and consent to participate: This study was conducted in compliance with the ethical principles outlined in the Helsinki Declaration [163] and with approval from the Victoria University Human Research Ethics Committee (application ID: HRE21-162, 14/3/22). All participants provided informed consent. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/10/30 06:29 MHDA- 2026/06/27 00:54 PMCR- 2025/10/29 CRDT- 2025/10/30 01:01 PHST- 2024/10/30 00:00 [received] PHST- 2025/08/06 00:00 [accepted] PHST- 2026/06/27 00:54 [medline] PHST- 2025/10/30 06:29 [pubmed] PHST- 2025/10/30 01:01 [entrez] PHST- 2025/10/29 00:00 [pmc-release] AID - 10.1186/s40359-025-03270-2 [pii] AID - 3270 [pii] AID - 10.1186/s40359-025-03270-2 [doi] PST - epublish SO - BMC Psychol. 2025 Oct 29;13(1):1193. doi: 10.1186/s40359-025-03270-2. PMID- 41162465 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Oct 29 TI - Association between mediterranean diet during pregnancy and gestational weight gain: a prospective cohort study. PG - 37787 LID - 10.1038/s41598-025-21443-2 [doi] LID - 37787 AB - Excessive gestational weight gain (GWG) elevated risks of gestational diabetes mellitus (GDM), pre-eclampsia, preterm birth, macrosomia, and infant mortality. This study investigated the relationship between the Mediterranean diet score (MDS) and GWG in Iranian pregnant women. We prospectively included 243 Iranian pregnant women aged 18-44 in Tehran. We assessed dietary intake through a validated Food Frequency Questionnaire (FFQ) in the third trimester. Physical activity was measured by the Pregnancy Physical Activity Questionnaire (PPAQ). Cox proportional hazard models were employed to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for inappropriate, inadequate, and excessive GWG by tertiles of MDS. During an average follow-up period of 3.86 weeks, 60, 99, and 159 cases of inadequate, excessive, and inappropriate GWG were recorded, respectively. We did not find any significant association between MDS and inadequate [HR, 0.69 (95% confidence interval: 0.35 to 1.37); P-trend = 0.303)], excessive [HR, 1.51 (0.91 to 2.49); P-trend = 0.120)], and inappropriate [HR, 1.18 (0.79 to 1.76); P-trend = 0.435)] GWG in the fully-adjusted model. Our findings indicated that MDS was not significantly associated with the risk of inappropriate, inadequate, and excessive GWG. Additional cohort studies with larger sample sizes and varied populations are needed to confirm these results. FAU - Moradi Baniasadi, Mohammadreza AU - Moradi Baniasadi M AD - Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran. AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O Box 14155-6117, Tehran, Iran. FAU - Tabaeifard, Razieh AU - Tabaeifard R AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O Box 14155-6117, Tehran, Iran. FAU - Mofidi Nejad, Maryam AU - Mofidi Nejad M AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O Box 14155-6117, Tehran, Iran. FAU - Omid, Noushin AU - Omid N AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O Box 14155-6117, Tehran, Iran. FAU - Karimi, Mehdi AU - Karimi M AD - Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. FAU - Azadbakht, Leila AU - Azadbakht L AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O Box 14155-6117, Tehran, Iran. azadbakhtleila@gmail.com. AD - Diabetic Research Center, Endocrine and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. azadbakhtleila@gmail.com. LA - eng PT - Journal Article DEP - 20251029 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - *Diet, Mediterranean MH - Pregnancy MH - *Gestational Weight Gain/physiology MH - Adult MH - Prospective Studies MH - Iran/epidemiology MH - Young Adult MH - Adolescent MH - Diabetes, Gestational/epidemiology MH - Proportional Hazards Models PMC - PMC12572121 OTO - NOTNLM OT - Cohort OT - Gestational weight gain OT - Iran OT - Maternal diet OT - Mediterranean diet score OT - Pregnant women COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/10/30 06:29 MHDA- 2026/06/27 00:53 PMCR- 2025/10/29 CRDT- 2025/10/30 00:22 PHST- 2024/12/26 00:00 [received] PHST- 2025/09/22 00:00 [accepted] PHST- 2026/06/27 00:53 [medline] PHST- 2025/10/30 06:29 [pubmed] PHST- 2025/10/30 00:22 [entrez] PHST- 2025/10/29 00:00 [pmc-release] AID - 10.1038/s41598-025-21443-2 [pii] AID - 21443 [pii] AID - 10.1038/s41598-025-21443-2 [doi] PST - epublish SO - Sci Rep. 2025 Oct 29;15(1):37787. doi: 10.1038/s41598-025-21443-2. PMID- 41159997 OWN - NLM STAT- MEDLINE DCOM- 20260107 LR - 20260712 IS - 1878-2620 (Electronic) IS - 1499-4046 (Linking) VI - 58 IP - 1 DP - 2026 Jan TI - Development of the TEACH Study: A Culturally Responsive Nutrition Intervention Program for Montessori Teachers. PG - 52-63 LID - S1499-4046(25)00427-0 [pii] LID - 10.1016/j.jneb.2025.09.004 [doi] AB - OBJECTIVE: To describe the intervention and research methods of the Teacher Education and Classroom Habits (TEACH) study, a social cognitive theory-based virtual nutrition intervention program for Montessori teachers to enhance teachers' personal and classroom nutrition beliefs and behaviors. DESIGN: This 12-week study will employ a cluster-randomized control design with a delayed intervention for the control group. SETTING: Montessori schools across the US with early childhood programs. PARTICIPANTS: Early childhood teachers will be recruited from approximately 29 Montessori schools across the US and randomized at the school level. INTERVENTION: The TEACH study will provide culturally focused nutrition education for Montessori teachers over 6 weeks, consisting of 4 program components, including an interactive online platform, live virtual education sessions, a Montessori-based nutrition curriculum, and parent education handouts. MAIN OUTCOME MEASURES: Using validated survey measures, changes in teachers' nutrition knowledge, nutrition self-efficacy, nutrition teaching self-efficacy, cultural competence, classroom eating behaviors, classroom food practices, nutrition teaching practices, and teacher-parent communication will be assessed at 3 timepoints (i.e., baseline, week 6, and week 12). ANALYSIS: Stepwise linear regressions will be used to assess relationships between baseline variables. Multilevel modeling will be used to determine the impact of the intervention. Statistical significance set at P /=18 years) who underwent spinal surgery in two referral hospitals in Tabriz (Imam Reza and Shohada) between March 2019 and February 2024. Postoperative infections were confirmed by infectious disease specialists. Data on demographics and surgical variables (including surgical site, approach, duration, blood loss, and transfusion) were collected using a standardized checklist. Statistical analyses were conducted in SPSS version 23.0 using Chi-squared and independent samples t-tests. Logistic regression was performed to estimate adjusted odds ratios (ORs) with 95% confidence intervals (CIs). RESULTS: The prevalence of postoperative spinal infections was 6%. Staphylococcus aureus was the most common pathogen (66.7%). Significant risk factors included female sex, older age, corticosteroid use, diabetes mellitus, longer surgery duration (>4 hours), blood loss (>1 liter), and blood transfusion (P<0.05). Diabetes (OR=5.90, 95% CI: 2.30-15.20) and prolonged surgery (OR=6.90, 95% CI: 2.50-19.00) showed the strongest associations. No significant associations were found for BMI, smoking, hypertension, CRP, ESR, surgical site, or technique. CONCLUSION: A 6% infection rate was identified, with several clinical and demographic factors increasing risk. Recognizing these predictors is essential for prevention. Broader, multi-center studies are recommended to validate findings and inform national surgical infection control policies. CI - (c) 2025 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. FAU - Mousavi, Seyed Taher AU - Mousavi ST AUID- ORCID: 0000-0003-2609-6066 AD - Department of Neurosurgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. FAU - Mirzaei, Farhad AU - Mirzaei F AD - Department of Neurosurgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. FAU - Shimia, Mohammad AU - Shimia M AD - Department of Neurosurgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. FAU - Shakeri, Moslem AU - Shakeri M AD - Department of Neurosurgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. LA - eng PT - Journal Article DEP - 20250901 PL - Iran TA - Arch Iran Med JT - Archives of Iranian medicine JID - 100889644 SB - IM MH - Humans MH - Iran/epidemiology MH - Male MH - Female MH - Risk Factors MH - Middle Aged MH - *Surgical Wound Infection/epidemiology/microbiology MH - Cross-Sectional Studies MH - Prevalence MH - Adult MH - Aged MH - Logistic Models MH - Young Adult MH - *Spine/surgery MH - Staphylococcal Infections/epidemiology MH - Age Factors MH - Adolescent MH - Operative Time MH - Sex Factors PMC - PMC12569995 OTO - NOTNLM OT - Microorganism OT - Postoperative infections OT - Risk factors OT - Spine OT - Surgery COIS- Competing Interests The authors declare no conflict of interest regarding this study and its publication. EDAT- 2025/10/29 06:27 MHDA- 2025/10/29 12:29 PMCR- 2025/09/01 CRDT- 2025/10/29 05:54 PHST- 2025/06/05 00:00 [received] PHST- 2025/08/10 00:00 [accepted] PHST- 2025/10/29 12:29 [medline] PHST- 2025/10/29 06:27 [pubmed] PHST- 2025/10/29 05:54 [entrez] PHST- 2025/09/01 00:00 [pmc-release] AID - 10.34172/aim.34624 [doi] PST - ppublish SO - Arch Iran Med. 2025 Sep 1;28(9):506-513. doi: 10.34172/aim.34624. Epub 2025 Sep 1. PMID- 41157512 OWN - NLM STAT- MEDLINE DCOM- 20251029 LR - 20260925 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 25 IP - 20 DP - 2025 Oct 18 TI - ViT-BiLSTM Multimodal Learning for Paediatric ADHD Recognition: Integrating Wearable Sensor Data with Clinical Profiles. LID - 10.3390/s25206459 [doi] LID - 6459 AB - ADHD classification has traditionally relied on accelerometer-derived tabular features, which summarise static activity but fail to capture spatial-temporal patterns, potentially limiting model performance. We developed a multimodal deep learning framework that transforms raw accelerometer signals into images and integrates them with clinical tabular data, enabling the joint exploration of dynamic activity patterns and static clinical characteristics. Data were collected from children aged 7-13 years, including accelerometer recordings from Apple Watches and clinical measures from standardised questionnaires. Deep learning models for image feature extraction and multiple fusion strategies were evaluated to identify the most effective representation and integration method. Our analyses indicated that combining activity images with clinical variables facilitated the classification of ADHD, with the ViT-BiLSTM model using cross-attention fusion achieving the highest performance. These findings suggest that multimodal learning can become a robust approach to ADHD classification by leveraging complementary information from activity dynamics and clinical data. Our framework and code will be made publicly available to support reproducibility and future research. FAU - Wang, Lin AU - Wang L AD - Department of Sports and Public Health, Faculty of Health and Life Sciences, University of Exeter, Exeter EX1 2LU, UK. AD - Department of Physical Education, Guilin University of Electronic Technology, Guilin 541004, China. FAU - Yang, Guang AU - Yang G AD - Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford OX3 7DQ, UK. LA - eng PT - Journal Article DEP - 20251018 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - *Attention Deficit Disorder with Hyperactivity/diagnosis/physiopathology MH - Child MH - Adolescent MH - *Wearable Electronic Devices MH - Accelerometry/methods MH - Female MH - Male MH - Deep Learning PMC - PMC12567585 OTO - NOTNLM OT - ADHD prediction OT - Vision Transformer (ViT) OT - accelerometer-based activity data OT - cross-attention fusion OT - multimodal deep learning COIS- The authors declare that no conflicts of interest exist. EDAT- 2025/10/29 06:27 MHDA- 2025/10/29 06:28 PMCR- 2025/10/18 CRDT- 2025/10/29 01:22 PHST- 2025/08/21 00:00 [received] PHST- 2025/10/12 00:00 [revised] PHST- 2025/10/14 00:00 [accepted] PHST- 2025/10/29 06:28 [medline] PHST- 2025/10/29 06:27 [pubmed] PHST- 2025/10/29 01:22 [entrez] PHST- 2025/10/18 00:00 [pmc-release] AID - s25206459 [pii] AID - sensors-25-06459 [pii] AID - 10.3390/s25206459 [doi] PST - epublish SO - Sensors (Basel). 2025 Oct 18;25(20):6459. doi: 10.3390/s25206459. PMID- 41156558 OWN - NLM STAT- MEDLINE DCOM- 20251029 LR - 20251208 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 20 DP - 2025 Oct 21 TI - Time-Restricted Eating and Prebiotic Supplementation Demonstrate Feasibility and Acceptability in Young Adult Pediatric Cancer Survivors: A Randomized Controlled Pilot Trial. LID - 10.3390/nu17203306 [doi] LID - 3306 AB - BACKGROUND: The optimization of treatment for pediatric cancer has increased 5-year survivor rates to over 80%. Currently, there are almost half a million survivors of a pediatric cancer alive in the United States, with numbers increasing worldwide. Despite increased survivorship, pediatric cancer survivors (PCSs) are at high risk for long-term chronic disease, including cardiometabolic dysregulation at an early age due to cancer-related treatments. PCSs often have increased adiposity, perturbation in the gut microbiome, and chronic systemic inflammation compared to age-matched controls. Time-restricted eating (TRE) has emerged as an effective dietary intervention to promote weight loss in individuals with increased adiposity and cardiometabolic disease. Prebiotic supplements may enhance the efficacy of TRE by promoting satiety via the gut microbiome. Given the accessibility of both TRE and prebiotic supplements, this type of dietary intervention may be ideal for young adult PCSs. The purpose of this study was to determine the feasibility and acceptability of 12 weeks of TRE with and without a prebiotic supplement among young adult PCSs. Changes in body weight, body composition, and cardiometabolic disease risk markers were explored. METHODS: Feasibility was measured based on recruitment (n = 20), retention (>80%), and adherence to the TRE eating window and prebiotic (>80%), and acceptability was measured based on a validated survey. Body weight, body composition, blood pressure, and additional blood-based cardiometabolic disease risk markers were also measured before and following the intervention. RESULTS: Feasibility was not met based on recruitment (n = 13), but retention and adherence exceeded the a priori hypothesis. Acceptability also met the a priori hypothesis. Improvements were observed in some cardiometabolic disease risk markers, including a significant decrease in fat mass and visceral fat mass in both groups following the intervention. CONCLUSIONS: Given the positive outcomes related to retention, adherence, and acceptability, as well as some cardiometabolic disease risk markers, a larger and longer study of TRE and prebiotic supplementation in PCSs is warranted. However, innovative recruitment strategies should be implemented, such as leveraging social media and targeting larger geographical areas, given recruitment challenges. FAU - Cares, Kate AU - Cares K AUID- ORCID: 0000-0001-5382-1409 AD - Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL 60612, USA. AD - University of Illinois Cancer Center, University of Illinois Chicago, Chicago, IL 60612, USA. FAU - Lima Oliveira, Manoela AU - Lima Oliveira M AD - Department of Health and Human Physiology, University of Iowa, Iowa City, IA 52242, USA. FAU - Bryner, Alyssa AU - Bryner A AD - Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL 60612, USA. FAU - Man, Bernice AU - Man B AD - Department of Medicine, Division of Academic Internal Medicine and Geriatrics, University of Illinois Chicago, Chicago, IL 60612, USA. FAU - Chen, Zhengjia AU - Chen Z AUID- ORCID: 0000-0002-6301-4931 AD - University of Illinois Cancer Center, University of Illinois Chicago, Chicago, IL 60612, USA. FAU - Bernabe, Beatriz Penalver AU - Bernabe BP AD - Department of Biomedical Engineering, College of Medicine, University of Illinois Chicago, Chicago, IL 60612, USA. FAU - Schmidt, Mary Lou AU - Schmidt ML AD - Department of Pediatrics, University of Illinois Chicago, Chicago, IL 60612, USA. FAU - Fitzgibbon, Marian AU - Fitzgibbon M AD - University of Illinois Cancer Center, University of Illinois Chicago, Chicago, IL 60612, USA. FAU - Gabel, Kelsey AU - Gabel K AUID- ORCID: 0000-0003-4613-8892 AD - Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL 60612, USA. AD - University of Illinois Cancer Center, University of Illinois Chicago, Chicago, IL 60612, USA. LA - eng GR - L30 CA295383/CA/NCI NIH HHS/United States GR - T32 CA057699/CA/NCI NIH HHS/United States GR - T32CA057699/CA/NCI NIH HHS/United States GR - L30CA295383/CA/NCI NIH HHS/United States PT - Journal Article PT - Randomized Controlled Trial DEP - 20251021 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Prebiotics) SB - IM MH - Humans MH - *Prebiotics/administration & dosage MH - *Cancer Survivors MH - Female MH - Male MH - Pilot Projects MH - Adolescent MH - Young Adult MH - *Dietary Supplements MH - Feasibility Studies MH - Child MH - Body Composition MH - *Neoplasms MH - Adult MH - Gastrointestinal Microbiome MH - Body Weight PMC - PMC12567023 OTO - NOTNLM OT - pediatric cancer survivors OT - prebiotics OT - time-restricted eating COIS- The authors declare no conflicts of interest. EDAT- 2025/10/29 06:28 MHDA- 2025/10/29 06:29 PMCR- 2025/10/21 CRDT- 2025/10/29 01:19 PHST- 2025/09/16 00:00 [received] PHST- 2025/10/13 00:00 [revised] PHST- 2025/10/16 00:00 [accepted] PHST- 2025/10/29 06:29 [medline] PHST- 2025/10/29 06:28 [pubmed] PHST- 2025/10/29 01:19 [entrez] PHST- 2025/10/21 00:00 [pmc-release] AID - nu17203306 [pii] AID - nutrients-17-03306 [pii] AID - 10.3390/nu17203306 [doi] PST - epublish SO - Nutrients. 2025 Oct 21;17(20):3306. doi: 10.3390/nu17203306. PMID- 41156546 OWN - NLM STAT- MEDLINE DCOM- 20251029 LR - 20251119 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 20 DP - 2025 Oct 20 TI - The Impact of Chinese Adult's Food Literacy on Healthy Eating Intentions Based on the Planned Behaviour Theory. LID - 10.3390/nu17203295 [doi] LID - 3295 AB - BACKGROUND: Unhealthy diets are major contributors to obesity and chronic diseases. In 2023, 50.7% of Chinese adults were overweight or obese, underscoring the need to strengthen healthy-eating intentions. METHODS: We analysed a cross-sectional online survey of 1145 adults (18-64 years) from Henan and Shandong. Moderation was tested using multiple linear regression with mean-centred interaction terms between each Theory of Planned Behaviour (TPB) construct (attitude, subjective norms, and perceived behavioural control [PBC]) and each food-literacy component (production, choices, preparation and cooking, intake, disposal). Models were adjusted for age, occupation, marital status, alcohol use, physician-diagnosed chronic disease, and living with family. To address multicollinearity, we performed a ridge-regression robustness check (L2-regularised linear model; lambda = 0.02 selected by 10-fold cross-validation; CV-RMSE = 0.483; CV-R(2) = 0.631). We report B, SE, beta, p-values, and R(2)/adjusted R(2). RESULTS: The overall food-literacy score did not significantly moderate the associations between attitude, subjective norms, or PBC and healthy-eating intention (p = 0.328, 0.671, 0.985). In component-wise analyses, only intake (intake) significantly moderated the PBC-intention association (B = 0.002, SE = 0.001, t = 2.497, p = 0.013); in the ridge model, the effect remained positive (beta = 0.182; lambda = 0.02). PBC (beta = 0.459) and subjective norms (beta = 0.169) were the strongest main-effect predictors. The best-fitting model explained R(2) = 0.663 of the variance in intention (adjusted R(2) = 0.663). CONCLUSIONS: Among adults in Henan and Shandong, the intake component of food literacy strengthened the association between PBC and healthy-eating intention, whereas overall food literacy showed no general moderating effect. Interventions should prioritise intake-related skills (e.g., portion planning, lower-sodium choices and nutrition label use) to enhance perceived behavioural control and, in turn, intention. Given the cross-sectional design, causal inference is limited; longitudinal, capability-building evaluations are warranted. FAU - Li, Yingying AU - Li Y AUID- ORCID: 0009-0002-8986-8377 AD - Department of Foodservice Management and Nutrition, Graduate School, Sangmyung University, Seoul 03016, Republic of Korea. FAU - Hwang, Ji-Yun AU - Hwang JY AUID- ORCID: 0000-0003-4003-1293 AD - Major of Foodservice Management and Nutrition, Sangmyung University, Seoul 03016, Republic of Korea. LA - eng GR - RS-2023-00280503/National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT)/ PT - Journal Article DEP - 20251020 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - Chinese people SB - IM MH - Humans MH - Adult MH - Female MH - Male MH - Middle Aged MH - *Diet, Healthy/psychology MH - Cross-Sectional Studies MH - China MH - Young Adult MH - *Intention MH - Adolescent MH - *Health Literacy MH - *Feeding Behavior/psychology MH - Health Behavior MH - Health Knowledge, Attitudes, Practice MH - East Asian People PMC - PMC12567545 OTO - NOTNLM OT - China OT - adults OT - behavioural intentions OT - food literacy OT - healthy eating habits OT - theory of planned behaviour COIS- The authors declare no conflicts of interest. EDAT- 2025/10/29 06:27 MHDA- 2025/10/29 06:28 PMCR- 2025/10/20 CRDT- 2025/10/29 01:19 PHST- 2025/09/20 00:00 [received] PHST- 2025/10/15 00:00 [revised] PHST- 2025/10/17 00:00 [accepted] PHST- 2025/10/29 06:28 [medline] PHST- 2025/10/29 06:27 [pubmed] PHST- 2025/10/29 01:19 [entrez] PHST- 2025/10/20 00:00 [pmc-release] AID - nu17203295 [pii] AID - nutrients-17-03295 [pii] AID - 10.3390/nu17203295 [doi] PST - epublish SO - Nutrients. 2025 Oct 20;17(20):3295. doi: 10.3390/nu17203295. PMID- 41156545 OWN - NLM STAT- MEDLINE DCOM- 20251029 LR - 20251101 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 20 DP - 2025 Oct 20 TI - Reliability of a Modified 24 h Dietary Recall and Veggie Meter to Assess Fruit and Vegetable Intake in New Zealand Children. LID - 10.3390/nu17203293 [doi] LID - 3293 AB - Adequate intake of fruits and vegetables (F + V) supports healthy growth and development in children, yet many New Zealand children do not meet national dietary recommendations, and methods to evaluate intake require good reliability. Objectives: To establish the validity and reliability of a modified 24 h multiple pass recall (MPR) for evaluating F + V and carotenoid intakes in children aged 9-13 years. The reliability of the Veggie Meter((R)) (VM((R))), a non-invasive reflection spectrometer to estimate skin carotenoid scores and derive blood carotenoid concentrations, was also examined. Methods: Thirty-two children (20 boys, 12 girls) completed three 24 h MPRs and parent-assisted weighed food diaries (WFDs) on randomised weekdays and weekends. Skin carotenoid scores were assessed using the VM((R)). The validity of the MPR was evaluated against WFDs using log-transformed Pearson correlations and mean x-axis bias. The reliability was assessed by the coefficient of variation (CV) and Pearson correlations. Results: Participants did not meet recommended F + V intakes (5-5.5 servings/day): MPR (mean fruit 1.3 servings/day; vegetables 2.0), WFD (fruit 1.3; vegetables 1.9). The MPR was a valid tool to estimate fruit and vegetable daily servings (combined-day Pearson coefficients > 0.71) with only trivial-small standardized mean bias-offset vs. WFD; however, the reliability was poor for the MPR-estimated carotenoid intake (CV 126%) and F + V intake. In contrast, the VM((R)) was reliable (Pearson correlation 0.97-0.99) with low measurement error (CV 4.0-5.2%). Conclusions: The modified 24 h MPR was valid but unreliable for estimating F + V and carotenoid intake. The VM((R)) demonstrated high reliability as a biomarker of skin carotenoid status in children. FAU - Patel, Varshika V AU - Patel VV AD - School of Sport, Exercise and Nutrition, Massey University, Auckland 0632, New Zealand. FAU - Perera, Thalagalage Shalika Harshani AU - Perera TSH AD - School of Sport, Exercise and Nutrition, Massey University, Auckland 0632, New Zealand. AD - Department of Sport Sciences and Physical Education, Sabaragamuwa University, Belihuloya 70140, Sri Lanka. FAU - Rush, Elaine AU - Rush E AUID- ORCID: 0000-0001-7713-6203 AD - Office of the Vice-Chancellor, AUT University, Auckland 1010, New Zealand. AD - Riddet Institute, Massey University, Palmerston North 4442, New Zealand. FAU - McArley, Sarah AU - McArley S AD - School of Sport, Exercise and Nutrition, Massey University, Auckland 0632, New Zealand. FAU - Wham, Carol AU - Wham C AUID- ORCID: 0000-0002-5136-1346 AD - School of Sport, Exercise and Nutrition, Massey University, Auckland 0632, New Zealand. FAU - Rowlands, David S AU - Rowlands DS AD - School of Sport, Exercise and Nutrition, Massey University, Auckland 0632, New Zealand. AD - Riddet Institute, Massey University, Palmerston North 4442, New Zealand. LA - eng GR - PG Award/School of Sport, Exercise, and Nutrition/ PT - Journal Article PT - Validation Study DEP - 20251020 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 36-88-4 (Carotenoids) SB - IM MH - Humans MH - Child MH - *Vegetables MH - Male MH - Female MH - *Fruit MH - New Zealand MH - Reproducibility of Results MH - Adolescent MH - Carotenoids/blood/analysis MH - *Mental Recall MH - Diet Records MH - *Diet MH - *Nutrition Assessment MH - *Diet Surveys PMC - PMC12566992 OTO - NOTNLM OT - 24 h multiple pass recall OT - Veggie Meter(R) OT - carotenoid OT - dietary intake assessment OT - fruit and vegetable OT - weighed food diary COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2025/10/29 06:28 MHDA- 2025/10/29 06:29 PMCR- 2025/10/20 CRDT- 2025/10/29 01:19 PHST- 2025/09/08 00:00 [received] PHST- 2025/10/11 00:00 [revised] PHST- 2025/10/13 00:00 [accepted] PHST- 2025/10/29 06:29 [medline] PHST- 2025/10/29 06:28 [pubmed] PHST- 2025/10/29 01:19 [entrez] PHST- 2025/10/20 00:00 [pmc-release] AID - nu17203293 [pii] AID - nutrients-17-03293 [pii] AID - 10.3390/nu17203293 [doi] PST - epublish SO - Nutrients. 2025 Oct 20;17(20):3293. doi: 10.3390/nu17203293. PMID- 41156540 OWN - NLM STAT- MEDLINE DCOM- 20251029 LR - 20251101 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 20 DP - 2025 Oct 20 TI - The Relationship Between Social Media Use and Disordered Eating in Young Adults Aged 18-30: A Narrative Review. LID - 10.3390/nu17203288 [doi] LID - 3288 AB - BACKGROUND/OBJECTIVES: Social media use has become ubiquitous, with governmental bodies and researchers expressing a growing concern about its impact on mental health. This review aims to examine the relationship between social media use and disordered eating in individuals aged 18-30. Specifically, we aim to identify specific patterns of use (including addictive use) that are associated with increased risk for disordered eating. METHODS: A search was conducted in March 2025 using PubMed and PsycINFO. Keywords were based on social media platforms and eating behaviors. Inclusion criteria were published studies in peer-reviewed journals from 2015-2025, written in English, with participants aged 18-30, whose disordered eating outcomes were assessed using validated measures. CONCLUSIONS: 637 articles were screened, with 28 studies meeting the inclusion criteria. Most studies assessed general social media use, without specifying the platform type. The EAT-26 and EDE-Q scales were used in most research to assess disordered eating. Data were narratively synthesized based on the type of social media variables assessed. Our findings demonstrate a complex relationship between social media use and disordered eating, with more consistent associations being found when the type of content (fitspiration and thinspiration) was the independent variable. These findings align with qualitative findings, which highlighted ambivalence in relation to the effect of social media: it is viewed as both a source of support and social comparison. Avenues for future research include longitudinal studies to understand the interaction between individual factors and social media patterns of use, as well as the utilization of platform-generated data on online engagement patterns. FAU - Athanasoula, Danai AU - Athanasoula D AUID- ORCID: 0000-0003-3518-0390 AD - Department of Psychology, The American College of Greece, GR15342 Athens, Greece. FAU - Salpa, Aikaterini AU - Salpa A AD - Department of Psychology, The American College of Greece, GR15342 Athens, Greece. FAU - Apergi, Fotini Sonia AU - Apergi FS AD - Department of Psychology, The American College of Greece, GR15342 Athens, Greece. FAU - Vlachos, Ilias I AU - Vlachos II AUID- ORCID: 0000-0001-9044-7081 AD - Department of Psychology, The American College of Greece, GR15342 Athens, Greece. LA - eng PT - Journal Article PT - Review DEP - 20251020 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Social Media/statistics & numerical data MH - *Feeding and Eating Disorders/psychology/epidemiology/etiology MH - Adolescent MH - Young Adult MH - Adult MH - Female MH - Male MH - *Feeding Behavior/psychology MH - Behavior, Addictive/psychology PMC - PMC12567364 OTO - NOTNLM OT - disordered eating OT - review OT - social media COIS- We have no conflicts of interest to disclose. EDAT- 2025/10/29 06:28 MHDA- 2025/10/29 06:29 PMCR- 2025/10/20 CRDT- 2025/10/29 01:19 PHST- 2025/08/13 00:00 [received] PHST- 2025/10/14 00:00 [revised] PHST- 2025/10/17 00:00 [accepted] PHST- 2025/10/29 06:29 [medline] PHST- 2025/10/29 06:28 [pubmed] PHST- 2025/10/29 01:19 [entrez] PHST- 2025/10/20 00:00 [pmc-release] AID - nu17203288 [pii] AID - nutrients-17-03288 [pii] AID - 10.3390/nu17203288 [doi] PST - epublish SO - Nutrients. 2025 Oct 20;17(20):3288. doi: 10.3390/nu17203288. PMID- 41156529 OWN - NLM STAT- MEDLINE DCOM- 20251029 LR - 20251101 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 20 DP - 2025 Oct 18 TI - Parental Intake of Eicosapentaenoic and Docosahexaenoic Acids in a Diverse, Urban City in the United States Is Associated with Indicators of Children's Health Potential. LID - 10.3390/nu17203277 [doi] LID - 3277 AB - Background/Objectives: Parents achieving recommended eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid intake can improve the health of parents and their children. Evidence links higher DHA intake to lower preterm birth (PTB) risk. With parental intake poorly defined, the objective is to characterize EPA and DHA intake by parents with children in households in a diverse, urban city. Methods: Parents with >/=1 child in the household completed a validated seven-question food frequency questionnaire to assess consumption of foods contributing most to EPA and DHA intake in American diets during the cross-sectional Voices of Child Health in Chicago Panel Survey (May-July 2022). Female respondents reported prior PTB. Home/residence information was linked to the Childhood Opportunity Index (COI). Multivariable linear regression and survey-weighted models evaluated parental characteristics associated with EPA+DHA intake. Pairwise comparisons estimated intake differences (mean (SE)) among groups. Results: Chicago parents (n = 1057) reported lower-than-recommended EPA+DHA intake and mothers consumed less compared to fathers (difference: 27.1 (11.4) mg/d; p = 0.02). Prior PTB was associated with lower EPA+DHA intake, yet DHA-containing supplement use, which occurred in ~25% of parents, was associated with higher intake (p < 0.05). Lower household income and a lower COI were associated with lower intake while parental race and ethnicity categories were also associated with intake (all p < 0.05); intake differed for mothers and fathers based on Black race and Hispanic ethnicity categories. Conclusions: The findings suggest that efforts aimed at improving parental EPA+DHA intake to improve the health of families should account for multidimensional influences on household food choices. FAU - Robinson, Daniel T AU - Robinson DT AUID- ORCID: 0000-0003-2450-9680 AD - Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. AD - Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA. FAU - Heffernan, Marie E AU - Heffernan ME AUID- ORCID: 0000-0002-4852-6963 AD - Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. AD - Mary Ann & J. Milburn Smith Child Health Outcomes, Research, and Evaluation Center, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA. FAU - Bendelow, Anne AU - Bendelow A AD - Data Analytics and Reporting, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA. FAU - Menker, Carly G AU - Menker CG AUID- ORCID: 0000-0001-6124-8155 AD - Mary Ann & J. Milburn Smith Child Health Outcomes, Research, and Evaluation Center, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA. FAU - Casale, Mia AU - Casale M AD - Nemours Children's Health, Wilmington, DE 19803, USA. FAU - Smith, Tracie AU - Smith T AD - Data Analytics and Reporting, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA. FAU - Davis, Matthew M AU - Davis MM AD - Nemours Children's Health, Wilmington, DE 19803, USA. FAU - Carlson, Susan E AU - Carlson SE AUID- ORCID: 0000-0003-3579-1685 AD - Department of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, KS 66103, USA. LA - eng GR - Not applicable/An anonymous family foundation dedicated to supporting research that advances community health in low-resource neighborhoods and the Patrick M. Magoon Institute for Healthy Communities./ PT - Journal Article DEP - 20251018 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - AAN7QOV9EA (Eicosapentaenoic Acid) RN - 25167-62-8 (Docosahexaenoic Acids) SB - IM MH - Humans MH - Female MH - *Eicosapentaenoic Acid/administration & dosage MH - Male MH - *Docosahexaenoic Acids/administration & dosage MH - *Parents MH - Chicago MH - Adult MH - Cross-Sectional Studies MH - Urban Population/statistics & numerical data MH - *Child Health/statistics & numerical data MH - *Diet/statistics & numerical data MH - Child MH - Premature Birth/prevention & control MH - United States PMC - PMC12566695 OTO - NOTNLM OT - docosahexaenoic acid OT - eicosapentaenoic acid OT - food frequency questionnaire OT - omega-3 fatty acids OT - parental dietary intake OT - preterm birth OT - seafoods COIS- Dr. Carlson is a member of the Seafood Nutrition Partnership Scientific Advisory Council. The other authors have no conflicts of interest to disclose. The foundation providing funding had no role in the design and conduct of this study. EDAT- 2025/10/29 06:27 MHDA- 2025/10/29 06:28 PMCR- 2025/10/18 CRDT- 2025/10/29 01:19 PHST- 2025/08/15 00:00 [received] PHST- 2025/10/10 00:00 [revised] PHST- 2025/10/16 00:00 [accepted] PHST- 2025/10/29 06:28 [medline] PHST- 2025/10/29 06:27 [pubmed] PHST- 2025/10/29 01:19 [entrez] PHST- 2025/10/18 00:00 [pmc-release] AID - nu17203277 [pii] AID - nutrients-17-03277 [pii] AID - 10.3390/nu17203277 [doi] PST - epublish SO - Nutrients. 2025 Oct 18;17(20):3277. doi: 10.3390/nu17203277. PMID- 41156441 OWN - NLM STAT- MEDLINE DCOM- 20251029 LR - 20251101 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 20 DP - 2025 Oct 10 TI - Early Maladaptive Schemas, Emotion Regulation, Stress, Social Support, and Lifestyle Factors as Predictors of Eating Behaviors and Diet Quality: Evidence from a Large Community Sample. LID - 10.3390/nu17203188 [doi] LID - 3188 AB - BACKGROUND: Psychological vulnerabilities, including early maladaptive schemas (EMSs), emotion regulation difficulties, perceived stress, and limited social support, are increasingly recognized as drivers of maladaptive eating and obesity. These findings underscore the need for health education and health promotion strategies that address psychological determinants of eating behavior. However, few studies integrate these psychological mechanisms with dietary and lifestyle indicators in both community and medical populations. METHODS: A total of 1500 adults (aged 18-65 years; 53% women) recruited from community and medical settings participated in the study. Data were collected between January 2018 and February 2025 using standardized paper-based questionnaires. Participants completed validated measures of EMSs (YSQ-S3), emotion regulation (DERS), stress (PSS-10), social support (MSPSS), eating-related behaviors (QERB), diet (FFQ-6; Unhealthy Diet Index [UDI]), and physical activity (IPAQ-SF). Anthropometric indices included body mass index (BMI) and waist circumference (WC) as an indicator of central adiposity. Analyses involved multivariate regression, mediation, and moderation models. RESULTS: EMSs were associated with emotional overeating and higher UDI scores. Difficulties in emotion regulation mediated the EMS-eating relationship (beta_indirect = 0.27, p < 0.001). Perceived stress amplified, while social support attenuated, the association between EMSs and emotion regulation difficulties. UDI was inversely related to physical activity (beta = -0.14, p < 0.01) and positively to sedentary time (beta = 0.12, p < 0.01). Both BMI and WC were higher among participants reporting greater stress, emotion dysregulation, and unhealthy eating. All effects remained robust after adjustment for age, gender, and BMI. CONCLUSIONS: Early maladaptive schemas and emotion regulation difficulties contribute to unhealthy dietary patterns and central adiposity, with stress and social support acting as contextual moderators. Integrating psychological assessment with validated dietary and lifestyle measures provides a comprehensive framework for obesity prevention and schema-informed interventions. From a lifespan perspective (18-65 years), these findings highlight the need for multidomain strategies targeting cognitive-emotional and behavioral mechanisms of weight regulation. FAU - Obara-Golebiowska, Malgorzata AU - Obara-Golebiowska M AD - Department of Clinical, Developmental and Educational Psychology, University of Warmia and Mazury, 10-719 Olsztyn, Poland. LA - eng PT - Journal Article DEP - 20251010 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Adult MH - *Social Support MH - Male MH - Middle Aged MH - *Feeding Behavior/psychology MH - *Stress, Psychological/psychology MH - Young Adult MH - *Life Style MH - Adolescent MH - *Emotional Regulation MH - Aged MH - *Diet/psychology MH - Body Mass Index MH - Surveys and Questionnaires MH - Obesity/psychology MH - Exercise MH - Waist Circumference PMC - PMC12566790 OTO - NOTNLM OT - diet quality OT - early maladaptive schemas OT - eating behavior OT - emotion regulation OT - health education and health promotion OT - obesity OT - perceived stress OT - physical activity OT - social support COIS- The author declares no conflicts of interest. EDAT- 2025/10/29 06:28 MHDA- 2025/10/29 06:29 PMCR- 2025/10/10 CRDT- 2025/10/29 01:18 PHST- 2025/09/22 00:00 [received] PHST- 2025/10/06 00:00 [revised] PHST- 2025/10/08 00:00 [accepted] PHST- 2025/10/29 06:29 [medline] PHST- 2025/10/29 06:28 [pubmed] PHST- 2025/10/29 01:18 [entrez] PHST- 2025/10/10 00:00 [pmc-release] AID - nu17203188 [pii] AID - nutrients-17-03188 [pii] AID - 10.3390/nu17203188 [doi] PST - epublish SO - Nutrients. 2025 Oct 10;17(20):3188. doi: 10.3390/nu17203188. PMID- 41156440 OWN - NLM STAT- MEDLINE DCOM- 20251029 LR - 20251208 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 20 DP - 2025 Oct 10 TI - Maternal Dietary Anthocyanidin, Dietary Inflammatory Potential, and Risk of Small-for-Gestational-Age in China. LID - 10.3390/nu17203187 [doi] LID - 3187 AB - Background: The interaction between anthocyanidin intake and dietary inflammatory potential might influence small-for-gestational-age (SGA), but the available evidence has been limited. This study aims to examine the associations of anthocyanidin with SGA and whether these associations change with dietary inflammatory potential. Methods: Data were derived from 2244 pregnant women enrolled in a community-based, randomized controlled trial between 2015 and 2019 in China. Anthocyanidin intake was calculated with the use of validated food-frequency questionnaires. The energy-adjusted dietary inflammatory index (EDII) was determined by aggregating data from 33 food parameters. Infant birth outcome measurements were obtained from hospital records. Associations were assessed by generalized estimating equations with adjustment for confounding factors. Results: During 39.7 gestational weeks of follow-up, 234 SGA cases occurred. The median intake of anthocyanidin was 28.7 mg/d. Higher consumption of total anthocyanidins (OR: 0.96, 95% CI: 0.95 to 0.97), cyanidin (OR: 0.96, 95% CI: 0.95 to 0.97), and peonidin (OR: 0.96, 95% CI: 0.96 to 0.97) subclasses was associated with a reduced risk of SGA. EDII was associated with an increased risk of SGA (OR: 1.08, 95% CI: 1.03 to 1.12). In addition, we observed that higher anthocyanidin intake was inversely associated with EDII (beta: -0.40, 95% CI: -0.46 to -0.34). The inverse anthocyanidin-SGA association was mostly greater among women in the highest tertile of EDII (OR: 0.67, 95% CI: 0.65 to 0.68) compared with the lowest tertile. Conclusions: Higher anthocyanidin intake was inversely associated with SGA, especially among women with higher EDII scores. FAU - Zhang, Binyan AU - Zhang B AUID- ORCID: 0000-0001-6307-9623 AD - School of Public Health, Xi'an Medical University, Xi'an 710021, China. AD - Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China. FAU - Xu, Kun AU - Xu K AD - Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Mi, Baibing AU - Mi B AUID- ORCID: 0000-0002-5208-7633 AD - Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China. FAU - Yan, Hong AU - Yan H AD - Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China. FAU - Wang, Duolao AU - Wang D AD - Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool L7 8XZ, UK. FAU - Dang, Shaonong AU - Dang S AUID- ORCID: 0000-0002-6980-8169 AD - Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China. FAU - Men, Ke AU - Men K AUID- ORCID: 0000-0001-5734-809X AD - School of Public Health, Xi'an Medical University, Xi'an 710021, China. LA - eng GR - 81230016/National Natural Science Foundation of China/ GR - 2024NLTS001/Special Program for Scientific and Technological Capacity Enhancement, Xi'an Medical University/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20251010 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Anthocyanins) SB - IM MH - Humans MH - Female MH - *Anthocyanins/administration & dosage/adverse effects MH - Pregnancy MH - China/epidemiology MH - Adult MH - *Infant, Small for Gestational Age MH - Infant, Newborn MH - *Diet/adverse effects MH - *Maternal Nutritional Physiological Phenomena MH - *Inflammation MH - Risk Factors PMC - PMC12567153 OTO - NOTNLM OT - anthocyanidin OT - dietary inflammatory index OT - pregnancy OT - small-for-gestational-age COIS- The authors declared no conflicts of interest. EDAT- 2025/10/29 06:27 MHDA- 2025/10/29 06:28 PMCR- 2025/10/10 CRDT- 2025/10/29 01:18 PHST- 2025/09/07 00:00 [received] PHST- 2025/10/06 00:00 [revised] PHST- 2025/10/08 00:00 [accepted] PHST- 2025/10/29 06:28 [medline] PHST- 2025/10/29 06:27 [pubmed] PHST- 2025/10/29 01:18 [entrez] PHST- 2025/10/10 00:00 [pmc-release] AID - nu17203187 [pii] AID - nutrients-17-03187 [pii] AID - 10.3390/nu17203187 [doi] PST - epublish SO - Nutrients. 2025 Oct 10;17(20):3187. doi: 10.3390/nu17203187. PMID- 41155779 OWN - NLM STAT- MEDLINE DCOM- 20251029 LR - 20251101 IS - 1648-9144 (Electronic) IS - 1010-660X (Print) IS - 1010-660X (Linking) VI - 61 IP - 10 DP - 2025 Oct 3 TI - Impact of Age and BMI on Spinal Anesthesia Characteristics in Pediatric Patients: A Retrospective Study. LID - 10.3390/medicina61101792 [doi] LID - 1792 AB - Background and Objectives: Spinal anesthesia is increasingly preferred in pediatric surgeries due to its rapid onset, high success rate, and low risk of systemic complications. However, the influence of age and body mass index (BMI) on block characteristics in adolescents remains insufficiently studied. Materials and Methods: This retrospective study evaluated 190 pediatric patients (aged 9-18 years; 154 male, 36 female) undergoing elective surgery with spinal anesthesia. Patients were stratified by age (Group 1: 9-14 years; Group 2: 15-18 years) and BMI (Group A: 16.00-19.65 kg/m(2); Group B: 19.66-23.31 kg/m(2)). The primary outcome was sensory block duration. Secondary outcomes included sedation requirements, complications, analgesic requirement times, and Visual Analog Scale (VAS) scores. Results: Group 2 had significantly longer sensory block duration and lower postoperative VAS scores at 3 and 12 h compared to Group 1 (p < 0.001). Lower BMI was associated with greater sedation requirements (p < 0.001) and a higher incidence of intraoperative nausea and vomiting (p = 0.013). Complications were infrequent (hypotension 6.3%, bradycardia 2.1%, PONV 7.1%, postoperative headache 3.1%) and managed conservatively. Conclusions: Age and BMI meaningfully influence spinal anesthesia characteristics in pediatric patients. Older adolescents achieved longer sensory block durations and better postoperative analgesia, whereas younger and lower-BMI patients required more sedation and had higher nausea rates. Individualized spinal anesthesia planning, considering age, BMI, and developmental stage, may optimize clinical outcomes. Prospective studies are warranted to validate these findings. FAU - Atlas, Ahmet AU - Atlas A AUID- ORCID: 0000-0001-5999-0510 AD - Department of Anesthesiology and Reanimation, Faculty of Medicine, Harran University, 63040 Sanliurfa, Turkey. FAU - Altay, Nuray AU - Altay N AD - Department of Anesthesiology and Reanimation, Faculty of Medicine, Harran University, 63040 Sanliurfa, Turkey. FAU - Buyukfirat, Evren AU - Buyukfirat E AUID- ORCID: 0000-0002-6396-0426 AD - Department of Anesthesiology and Reanimation, Faculty of Medicine, Harran University, 63040 Sanliurfa, Turkey. FAU - Sengel, Abdulhakim AU - Sengel A AUID- ORCID: 0000-0003-0905-1018 AD - Department of Anesthesiology and Reanimation, Faculty of Medicine, Harran University, 63040 Sanliurfa, Turkey. FAU - Aslanparcasi, Ramazan AU - Aslanparcasi R AD - Sanliurfa Mehmet Akif Inan Egitim ve Arastirma Hastanesi, 63040 Haliliye, Turkey. FAU - Sengul, Abdullah AU - Sengul A AUID- ORCID: 0000-0002-2111-087X AD - Sanliurfa Mehmet Akif Inan Egitim ve Arastirma Hastanesi, 63040 Haliliye, Turkey. LA - eng PT - Journal Article DEP - 20251003 PL - Switzerland TA - Medicina (Kaunas) JT - Medicina (Kaunas, Lithuania) JID - 9425208 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - Retrospective Studies MH - *Anesthesia, Spinal/methods/standards/adverse effects/statistics & numerical data MH - Adolescent MH - *Body Mass Index MH - Age Factors PMC - PMC12566371 OTO - NOTNLM OT - BMI OT - bupivacaine OT - pediatric anesthesia OT - regional anesthesia OT - sedation OT - sensory block duration OT - spinal block COIS- The authors declare no conflict of interest. EDAT- 2025/10/29 06:27 MHDA- 2025/10/29 06:28 PMCR- 2025/10/03 CRDT- 2025/10/29 01:16 PHST- 2025/08/22 00:00 [received] PHST- 2025/09/19 00:00 [revised] PHST- 2025/10/02 00:00 [accepted] PHST- 2025/10/29 06:28 [medline] PHST- 2025/10/29 06:27 [pubmed] PHST- 2025/10/29 01:16 [entrez] PHST- 2025/10/03 00:00 [pmc-release] AID - medicina61101792 [pii] AID - medicina-61-01792 [pii] AID - 10.3390/medicina61101792 [doi] PST - epublish SO - Medicina (Kaunas). 2025 Oct 3;61(10):1792. doi: 10.3390/medicina61101792. PMID- 41154332 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251029 LR - 20251101 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 13 IP - 20 DP - 2025 Oct 21 TI - Neurodevelopmental Pathways from Maternal Obesity to Offspring Outcomes: An Umbrella Review of Cognitive and Behavioral Consequences Across Development. LID - 10.3390/healthcare13202653 [doi] LID - 2653 AB - Background: Maternal obesity affects 20-25% of pregnancies globally and has been associated with adverse offspring neurodevelopmental outcomes. This umbrella review synthesized evidence on neurodevelopmental pathways linking maternal obesity to offspring cognitive, executive, and behavioral outcomes. Methods: Following PRISMA 2020 guidelines, we systematically searched six databases (PubMed/MEDLINE, Scopus, Web of Science, PsycINFO, EMBASE, CINAHL) for studies published 2008-2024. We included original peer-reviewed studies examining maternal pre-pregnancy obesity (BMI >/= 30 kg/m(2)) and offspring neurodevelopmental outcomes using prospective cohort, experimental, neuroimaging, or systematic review designs with validated assessments. Risk of bias was assessed using Newcastle-Ottawa Scale, Cochrane RoB 2.0, and SYRCLE guidelines. Results: Analysis of 78 studies encompassing 650,000+ mother-child pairs from 17 countries revealed significant associations. Study designs included prospective cohorts (59%), animal experiments (22%), systematic reviews/meta-analyses (13%), neuroimaging studies (4%), and randomized trials (3%). Maternal obesity (BMI >/= 30 kg/m(2)) was associated with reduced cognitive abilities (IQ differences: -2.5 to -5.8 points), impaired executive function (OR 1.4-2.3), and increased ADHD symptoms (OR 1.4-2.8) and emotional dysregulation (OR 1.5-2.2). Dose-response relationships revealed threshold effects at BMI >/= 30 kg/m(2), accelerating at BMI >/= 35 kg/m(2). Four primary mechanistic pathways were identified: inflammatory, metabolic, epigenetic, and neurotransmitter alterations. Only 57.7% of studies used prospectively measured pre-pregnancy BMI. Conclusions: Observational and experimental evidence indicates maternal obesity represents a modifiable risk factor for offspring neurodevelopmental impairment. The primarily observational human evidence, supported by mechanistic animal studies, suggests multimodal interventions targeting identified pathways during critical windows (pre-conception through early postnatal period) warrant investigation. FAU - Gkintoni, Evgenia AU - Gkintoni E AUID- ORCID: 0000-0002-3197-2019 AD - Laboratory of Public Health, Department of Medicine, University of Patras, 26504 Patras, Greece. AD - Department of Psychiatry, University General Hospital of Patras, 26504 Patras, Greece. FAU - Papachatzi, Eleni AU - Papachatzi E AUID- ORCID: 0000-0003-4095-6827 AD - Laboratory of Public Health, Department of Medicine, University of Patras, 26504 Patras, Greece. AD - Department of Pediatrics, University General Hospital of Patras, 26504 Patras, Greece. FAU - Efthymiadou, Erifili AU - Efthymiadou E AUID- ORCID: 0000-0001-6416-4037 AD - Lucy Faithfull Foundation, Epsom KT17 1HQ, UK. FAU - Magriplis, Emmanuella AU - Magriplis E AUID- ORCID: 0000-0001-6517-6857 AD - Laboratory of Public Health, Department of Medicine, University of Patras, 26504 Patras, Greece. AD - Laboratory of Dietetics and Quality of Life, Department of Food Science and Human Nutrition, Agricultural University of Athens, 26504 Athens, Greece. FAU - Vantarakis, Apostolos AU - Vantarakis A AUID- ORCID: 0000-0003-4411-3739 AD - Laboratory of Public Health, Department of Medicine, University of Patras, 26504 Patras, Greece. LA - eng PT - Journal Article PT - Review DEP - 20251021 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12563868 OTO - NOTNLM OT - ADHD OT - behavioral outcomes OT - cognitive development OT - developmental programming OT - epigenetics OT - executive function OT - inflammatory pathways OT - maternal obesity OT - neurodevelopment OT - umbrella review COIS- The authors declare no conflicts of interest. EDAT- 2025/10/29 06:28 MHDA- 2025/10/29 06:29 PMCR- 2025/10/21 CRDT- 2025/10/29 01:09 PHST- 2025/08/21 00:00 [received] PHST- 2025/10/15 00:00 [revised] PHST- 2025/10/16 00:00 [accepted] PHST- 2025/10/29 06:29 [medline] PHST- 2025/10/29 06:28 [pubmed] PHST- 2025/10/29 01:09 [entrez] PHST- 2025/10/21 00:00 [pmc-release] AID - healthcare13202653 [pii] AID - healthcare-13-02653 [pii] AID - 10.3390/healthcare13202653 [doi] PST - epublish SO - Healthcare (Basel). 2025 Oct 21;13(20):2653. doi: 10.3390/healthcare13202653. PMID- 41153542 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251029 LR - 20251101 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 10 DP - 2025 Oct 9 TI - Reliability and Validity of the HBSC Physical Activity Questionnaire in Japanese Adolescents. LID - 10.3390/children12101360 [doi] LID - 1360 AB - Background/Objectives: International physical activity (PA) questionnaires require a reliability and validity assessment in many countries to understand cross-cultural differences accurately. The current study examined the reliability and validity of the Japanese version of the WHO Health Behaviour in School-aged Children PA (HBSC-J) survey in adolescent students in Japan. Methods: The participants were 215 Japanese high school students. The HBSC-J was administered twice to measure reliability. The PA in the last week evaluated using the HBSC-J was compared with the PA evaluated using a triaxial accelerometer to measure the concurrent validity. Results: The intraclass correlation coefficients (ICCs) for reliability were 0.74 for the number of days, with 60 min/day or more of moderate-to-vigorous PA (MVPA). For the days with an MVPA of 60 min/day or more, ICCs were lower for girls (0.63 [0.49-0.74]) than boys (0.82 [0.75-0.87]). Positive correlations were observed between the accelerometry MVPA and the number of days, with at least 60 min/day of MVPA (r = 0.44). Conclusions: The HBSC-J questionnaire should be acceptable for evaluating MVPA in Japanese adolescents, with a reasonable reliability and validity. FAU - Tanaka, Chiaki AU - Tanaka C AUID- ORCID: 0000-0001-9113-436X AD - Department of Human Nutrition, Tokyo Kasei Gakuin University, 2 Sanbancho, Chiyoda-ku 102-8341, Tokyo, Japan. AD - National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Settsu 566-0002, Osaka, Japan. AD - Institute of Nutrition Sciences, Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado 350-0288, Saitama, Japan. FAU - Watanabe, Masashi AU - Watanabe M AUID- ORCID: 0009-0006-5059-5518 AD - Faculty of Education, Ibaraki University, 2-1-1 Bunkyo, Mito 310-8512, Ibaraki, Japan. FAU - Oishi, Kan AU - Oishi K AD - Faculty of Education, Saga University, 1 Honjo, Saga 840-8502, Saga, Japan. AD - Faculty of Health and Sports Science, Doshisha University, 1-3 Tatara Miyakodani, Kyotanabe-shi 610-0394, Kyoto, Japan. FAU - Reilly, John J AU - Reilly JJ AUID- ORCID: 0000-0001-6165-5471 AD - Physical Activity for Health Group, Department of Psychological, Sciences and Health, University of Strathclyde, 16 Richmond Street, Glasgow G1 1XQ, UK. FAU - Ishii, Kojiro AU - Ishii K AUID- ORCID: 0000-0002-3310-9470 AD - Faculty of Health and Sports Science, Doshisha University, 1-3 Tatara Miyakodani, Kyotanabe-shi 610-0394, Kyoto, Japan. FAU - Tanaka, Shigeho AU - Tanaka S AUID- ORCID: 0000-0002-8933-3041 AD - National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Settsu 566-0002, Osaka, Japan. AD - Institute of Nutrition Sciences, Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado 350-0288, Saitama, Japan. AD - Faculty of Nutrition, Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado 350-0288, Saitama, Japan. LA - eng PT - Journal Article DEP - 20251009 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12562882 OTO - NOTNLM OT - accelerometry OT - adolescence OT - exercise OT - self report OT - sex COIS- The authors declare no conflicts of interest. EDAT- 2025/10/29 06:28 MHDA- 2025/10/29 06:29 PMCR- 2025/10/09 CRDT- 2025/10/29 01:02 PHST- 2025/08/23 00:00 [received] PHST- 2025/09/27 00:00 [revised] PHST- 2025/10/03 00:00 [accepted] PHST- 2025/10/29 06:29 [medline] PHST- 2025/10/29 06:28 [pubmed] PHST- 2025/10/29 01:02 [entrez] PHST- 2025/10/09 00:00 [pmc-release] AID - children12101360 [pii] AID - children-12-01360 [pii] AID - 10.3390/children12101360 [doi] PST - epublish SO - Children (Basel). 2025 Oct 9;12(10):1360. doi: 10.3390/children12101360. PMID- 41153472 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251029 LR - 20251101 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 10 DP - 2025 Sep 24 TI - Validation of the Italian Translation and Cultural Adaptation of the Canadian Assessment of Physical Literacy-2 (CAPL-2) Questionnaire for Children. LID - 10.3390/children12101290 [doi] LID - 1290 AB - BACKGROUND/OBJECTIVES: Physical literacy is a holistic concept promoting lifelong health by considering an individual's lived experience within their cultural context. This necessitates context-specific conceptualizations and pedagogies, highlighting the need for valid assessment tools for physical and sport educators. The Canadian Assessment of Physical Literacy (CAPL-2) is a well-known validated tool. This study aimed to validate the Italian translation and cultural adaptation of the CAPL-2 questionnaire for children aged 8-12. METHODS: The CAPL-2 questionnaire was translated using a forward-backward procedure by bilingual experts. Subsequently, 111 Italian children (57 females, mean BMI 17.9 kg/m(2)) completed the adapted CAPL-2 questionnaire twice over 10 days under supervision. The internal consistency of CAPL-2 was assessed with Cronbach's alpha. ROC curve analysis and AUC evaluated the CAPL-2's ability to predict adherence to WHO physical activity guidelines based on self-reported activity. RESULTS: Results showed high internal consistency for the motivation and confidence domain (Cronbach's alpha: 0.88-0.97) but lower consistency for the knowledge and understanding domain (Cronbach's alpha: 0.20-0.34). Despite this, the CAPL-2 questionnaire demonstrated high predictive performance in identifying children active for at least 5 days (AUC: 0.95) or 6 days (AUC: 0.89). CONCLUSIONS: The Italian version of CAPL-2 is a reliable tool for assessing physical literacy in Italian children aged 8 to 12, addressing key aspects such as motivation, confidence, physical skills, understanding of physical activity, and daily habits. It offers a valuable and culturally adapted instrument for trainers, teachers and educators in physical activity and sport contexts. FAU - Iannaccone, Alice AU - Iannaccone A AUID- ORCID: 0000-0002-6300-7758 AD - Department of Human Sciences, Society and Health, University of Cassino and Southern Lazio, Via Sant'Angelo, Loc. Folcara, 03043 Cassino, Italy. AD - European University of Technology EUt+, European Union. FAU - Cudicio, Alessandro AU - Cudicio A AUID- ORCID: 0000-0003-1891-3812 AD - Department of Human and Social Sciences, University of Bergamo, 24129 Bergamo, Italy. FAU - Falese, Lavinia AU - Falese L AUID- ORCID: 0000-0002-7767-6717 AD - Department of Human Sciences, Society and Health, University of Cassino and Southern Lazio, Via Sant'Angelo, Loc. Folcara, 03043 Cassino, Italy. AD - European University of Technology EUt+, European Union. FAU - Federico, Bruno AU - Federico B AUID- ORCID: 0000-0002-1444-2585 AD - Department of Human Sciences, Society and Health, University of Cassino and Southern Lazio, Via Sant'Angelo, Loc. Folcara, 03043 Cassino, Italy. AD - European University of Technology EUt+, European Union. FAU - Crotti, Matteo AU - Crotti M AD - Department of Human and Social Sciences, University of Bergamo, 24129 Bergamo, Italy. FAU - Lovecchio, Nicola AU - Lovecchio N AUID- ORCID: 0000-0003-4115-0833 AD - Department of Human and Social Sciences, University of Bergamo, 24129 Bergamo, Italy. FAU - Digennaro, Simone AU - Digennaro S AUID- ORCID: 0000-0002-7714-8658 AD - Department of Human Sciences, Society and Health, University of Cassino and Southern Lazio, Via Sant'Angelo, Loc. Folcara, 03043 Cassino, Italy. AD - European University of Technology EUt+, European Union. FAU - Agosti, Valeria AU - Agosti V AUID- ORCID: 0000-0002-1237-7097 AD - Department of Humanities, Philosophy and Education, University of Salerno, 84084 Fisciano, Italy. LA - eng PT - Journal Article DEP - 20250924 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12563355 OTO - NOTNLM OT - active lifestyle OT - assessment OT - children OT - cross-cultural adaptation OT - health OT - lifelong OT - physical activity OT - physical education OT - physical literacy OT - sport COIS- The authors declare no conflicts of interest. EDAT- 2025/10/29 06:27 MHDA- 2025/10/29 06:28 PMCR- 2025/09/24 CRDT- 2025/10/29 01:02 PHST- 2025/08/05 00:00 [received] PHST- 2025/08/25 00:00 [revised] PHST- 2025/09/18 00:00 [accepted] PHST- 2025/10/29 06:28 [medline] PHST- 2025/10/29 06:27 [pubmed] PHST- 2025/10/29 01:02 [entrez] PHST- 2025/09/24 00:00 [pmc-release] AID - children12101290 [pii] AID - children-12-01290 [pii] AID - 10.3390/children12101290 [doi] PST - epublish SO - Children (Basel). 2025 Sep 24;12(10):1290. doi: 10.3390/children12101290. PMID- 41153240 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251029 LR - 20251101 IS - 2075-4418 (Print) IS - 2075-4418 (Electronic) IS - 2075-4418 (Linking) VI - 15 IP - 20 DP - 2025 Oct 12 TI - Association of Hemoglobin to Red Blood Cell Distribution Width Ratio and Total Bone Mineral Density in U.S. Adolescents: The NHANES 2011-2018. LID - 10.3390/diagnostics15202567 [doi] LID - 2567 AB - Background: The hemoglobin-to-red-cell distribution width ratio has emerged as a novel prognostic marker in various clinical settings. However, its association with total bone mineral density in adolescents remains inadequately explored. Methods: This cross-sectional study was based on data from the 2011-2018 National Health and Nutrition Examination Survey, including adolescents aged 12-19 years with complete data on hemoglobin, red cell distribution width, and total bone mineral density. Weighted multivariable linear regression models and generalized additive models were used to evaluate the association between hemoglobin-to-red-cell distribution width and total bone mineral density. A two-piecewise linear regression model was applied to assess potential threshold effects, with log-likelihood ratio tests used to determine the significance of inflection points. Subgroup and interaction analyses were further conducted to examine whether age, sex, race, and milk product consumption modified this association. Results: A total of 3789 adolescents were included. Participants in the highest hemoglobin-to-red-blood-cell distribution width ratio quartile had significantly higher hemoglobin levels, lower red blood cell distribution width, greater total bone mineral density, higher total calcium and blood urea nitrogen levels, and lower body mass index, high-density lipoprotein cholesterol, and serum 25OHD levels compared to lower quartiles. The hemoglobin-to-red-blood-cell distribution width ratio was positively associated with total bone mineral density (fully adjusted beta = 0.078, 95% CI: 0.053, 0.104, p < 0.0001). A two-piecewise linear regression model identified an inflection point at the hemoglobin-to-red-cell distribution width ratio = 1.055; the positive association became stronger above this threshold (beta = 0.143 vs. beta = 0.039 below the threshold, p = 0.003 for nonlinearity). Subgroup analysis revealed significant gender interactions (p < 0.0001). A higher HRR was significantly associated with greater total BMD in males (beta = 0.130, 95% CI: 0.089-0.171, p < 0.0001), whereas no significant association was observed in females (beta = -0.009, 95% CI: -0.043-0.025, p = 0.604). Positive associations were also observed among participants aged 12-15 years, non-Hispanic Whites, non-Hispanic Blacks, other Hispanics, Mexican Americans, and frequent milk consumers. Conclusions: Our results indicate that the hemoglobin-to-red-cell distribution width ratio shows a potential association with bone mineral density in male adolescents, which may offer supportive value for bone health assessment but requires further validation. FAU - Guo, Tianhao AU - Guo T AD - Department of Hand Surgery, Hebei Medical University Third Hospital, Shijiazhuang 050051, China. FAU - Xiao, Jiheng AU - Xiao J AUID- ORCID: 0000-0003-1133-4703 AD - Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. FAU - Yao, Xinjun AU - Yao X AD - Department of Hand Surgery, Hebei Medical University Third Hospital, Shijiazhuang 050051, China. FAU - Bai, Jiangbo AU - Bai J AD - Department of Hand Surgery, Hebei Medical University Third Hospital, Shijiazhuang 050051, China. FAU - Yu, Yadong AU - Yu Y AD - Department of Hand Surgery, Hebei Medical University Third Hospital, Shijiazhuang 050051, China. LA - eng PT - Journal Article DEP - 20251012 PL - Switzerland TA - Diagnostics (Basel) JT - Diagnostics (Basel, Switzerland) JID - 101658402 PMC - PMC12564136 OTO - NOTNLM OT - adolescents OT - bone health OT - hematological biomarkers OT - osteoporosis risk OT - pediatric population OT - skeletal development COIS- The authors declare no conflicts of interest. EDAT- 2025/10/29 06:28 MHDA- 2025/10/29 06:29 PMCR- 2025/10/12 CRDT- 2025/10/29 01:01 PHST- 2025/09/16 00:00 [received] PHST- 2025/10/01 00:00 [revised] PHST- 2025/10/02 00:00 [accepted] PHST- 2025/10/29 06:29 [medline] PHST- 2025/10/29 06:28 [pubmed] PHST- 2025/10/29 01:01 [entrez] PHST- 2025/10/12 00:00 [pmc-release] AID - diagnostics15202567 [pii] AID - diagnostics-15-02567 [pii] AID - 10.3390/diagnostics15202567 [doi] PST - epublish SO - Diagnostics (Basel). 2025 Oct 12;15(20):2567. doi: 10.3390/diagnostics15202567. PMID- 41152826 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260630 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Oct 28 TI - Factor structure of food and physical activity parenting practices among US fathers by ethnicity and survey language: a cross sectional study. PG - 3625 LID - 10.1186/s12889-025-24584-1 [doi] LID - 3625 AB - BACKGROUND: Parenting practices contribute to children's eating and physical activity behaviors, and thereby their risk of obesity and associated medical conditions. Fathers may engage in different parenting practices than mothers. The objective of this study was therefore to establish psychometrically sound tools in English and Spanish for measuring Physical Activity Parenting Practices (PAPP) and Food Parenting Practices (FPP) for Hispanic and non-Hispanic fathers of diverse races for use in future studies, such as evaluations of family-based obesity interventions targeted at fathers. METHODS: We conducted a preliminary assessment of the psychometric properties of a reduced version of the PAPP and FPP item banks which were administered in English or Spanish to 639 fathers of 5-11 year old children. We used confirmatory factor analyses (CFA) to examine factor structures of the reduced item banks by survey language and ethnicity (Hispanic, non-Hispanic). The internal consistency of the scales were assessed using Cronbach's alpha. RESULTS: We identified three factors for PAPP (Autonomy Support, Co-Participation/Modeling, Coercive Control) with two sub-factors each; four factors for FPP (Child Involvement, Covert Control, Modeling, Threats & Bribes) without sub-factors. The solutions performed well in the samples of English and Spanish-speaking fathers. The fit of the FPP factors was adequate among fathers who completed the survey in English, and to a lesser extent among Spanish-speaking fathers, albeit acceptable. A bi-factor model, where each item loads on a primary dimension and supports the use of global factors, was identified for all PAPP scales in both languages with adequate internal consistency and fit. The CFA structure observed by survey language versions was less supported across ethnicities, but did not diverge enough to warrant major modifications. The internal consistency of the FPP Covert Control factor among Hispanics and the Spanish survey sample was low. CONCLUSIONS: This work builds on previously published psychometrics of a large item bank for improving fathers' measurement of PAPP and FPP. Findings support the use of a reduced version of the parenting practices for fathers when administering the survey in English and Spanish. Further research is needed to investigate the measurement of fathers' parenting practices across other Spanish speaking groups. FAU - Musaad, Salma M A AU - Musaad SMA AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates Street, Houston, TX, 77030, USA. salma.musaad@bcm.edu. FAU - Masse, Louise C AU - Masse LC AD - School of Population and Public Health, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada. FAU - Beltran, Alicia AU - Beltran A AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates Street, Houston, TX, 77030, USA. FAU - Perez, Oriana AU - Perez O AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates Street, Houston, TX, 77030, USA. FAU - O'Connor, Teresia M AU - O'Connor TM AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates Street, Houston, TX, 77030, USA. LA - eng GR - R34 HL131726/HL/NHLBI NIH HHS/United States GR - R34HL131726/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20251028 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Male MH - *Parenting/ethnology/psychology MH - Cross-Sectional Studies MH - *Fathers/psychology/statistics & numerical data MH - Psychometrics MH - United States MH - Factor Analysis, Statistical MH - Child, Preschool MH - *Exercise/psychology MH - Child MH - Surveys and Questionnaires MH - *Language MH - Hispanic or Latino/statistics & numerical data/psychology MH - Adult MH - *Ethnicity/statistics & numerical data/psychology PMC - PMC12560397 OTO - NOTNLM OT - Child feeding OT - Child physical activity OT - Confirmatory factor analysis OT - Parenting practices COIS- Declarations. Ethics approval and consent to participate: This research was approved by the Institutional Review Board at Baylor College of Medicine [protocol H-38237] and meets all requirements for ethical conduct for research with human subjects. The secure internet survey included a cover letter of consent. Only fathers who agreed to participate could access and respond to the full survey. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/10/29 06:28 MHDA- 2026/06/27 00:59 PMCR- 2025/10/28 CRDT- 2025/10/29 00:50 PHST- 2024/03/01 00:00 [received] PHST- 2025/08/25 00:00 [accepted] PHST- 2026/06/27 00:59 [medline] PHST- 2025/10/29 06:28 [pubmed] PHST- 2025/10/29 00:50 [entrez] PHST- 2025/10/28 00:00 [pmc-release] AID - 10.1186/s12889-025-24584-1 [pii] AID - 24584 [pii] AID - 10.1186/s12889-025-24584-1 [doi] PST - epublish SO - BMC Public Health. 2025 Oct 28;25(1):3625. doi: 10.1186/s12889-025-24584-1. PMID- 41150828 OWN - NLM STAT- MEDLINE DCOM- 20251028 LR - 20260601 IS - 1932-846X (Electronic) IS - 1932-8451 (Linking) VI - 85 IP - 4 DP - 2025 Oct TI - Facial Morphometric Features in Autism Spectrum Disorder: Preliminary Findings From Canonical Discriminant Analysis. PG - e23011 LID - 10.1002/dneu.23011 [doi] AB - Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by impairments in social communication and the presence of restricted, repetitive behaviors. Although there is no cure for ASD, early diagnosis and evidence-based interventions can significantly improve developmental outcomes. However, many children are diagnosed later than recommended, limiting timely access to appropriate support services. This proof-of-concept study examines whether facial morphometric characteristics, analyzed through canonical discriminant analysis (CDA), can differentiate children with ASD from their typically developing (TD) peers. The study included 40 children diagnosed with ASD and 40 age- and gender-matched TD controls. Standardized facial photographs were taken in the Frankfurt Horizontal plane in accordance with biometric photography guidelines. Anthropometric landmarks were identified, and inter-landmark distances were measured using the ImageJ software. CDA was then performed in SPSS 28.0 to develop a statistical classification model. CDA was conducted to differentiate ASD and TD groups based on facial morphometric features. While overall facial morphology alone did not significantly distinguish the groups, specific regions-particularly the eyes and lips-showed significant discriminatory power. The nasal profile demonstrated moderate differentiation, and the strongest separation was achieved when combining overall facial and organ-specific features, with a canonical correlation of 0.74 and a significant Wilks' Lambda (Lambda = 0.453, chi(2)(8) = 58.651, p < 0.001). The present findings suggest that specific facial regions, particularly the eyes and lips, may carry morphometric features that significantly differentiate children with ASD from their TD peers. While overall facial morphology alone did not provide sufficient discrimination, combining overall facial and organ-specific measurements improved group separation (canonical correlation = 0.74). These results should be regarded as preliminary, highlighting the potential of facial morphometrics as a supplementary, non-invasive research tool. External validation with larger, ethnically diverse samples remains essential before any clinical or screening applicability can be considered. CI - (c) 2025 Wiley Periodicals LLC. FAU - Kilicaslan, Fethiye AU - Kilicaslan F AUID- ORCID: 0000-0002-8131-8859 AD - Department of Child and Adolescent Psychiatry, Harran University, Faculty of Medicine, Sanliurfa, Turkiye. FAU - Babacan, Serdar AU - Babacan S AD - Department of Anatomy, Uludag University, Faculty of Medicine, Bursa, Turkiye. FAU - Colak, Bahaddin AU - Colak B AD - Department of Child and Adolescent Psychiatry, Harran University, Faculty of Medicine, Sanliurfa, Turkiye. FAU - Bayazit, Huseyin AU - Bayazit H AD - Lurie Center for Autism, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA. FAU - Deniz, Mustafa AU - Deniz M AD - Department of Anatomy, Harran University, Faculty of Medicine, Sanliurfa, Turkiye. LA - eng GR - Harran University Scientific Investigation Coordination Committee./ PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Dev Neurobiol JT - Developmental neurobiology JID - 101300215 SB - IM MH - Humans MH - *Autism Spectrum Disorder/pathology/diagnosis MH - Male MH - Female MH - *Face/pathology MH - Child MH - Discriminant Analysis MH - Child, Preschool OTO - NOTNLM OT - Autism spectrum disorder OT - biomarker OT - canonical discriminant analysis OT - craniofacial features OT - photogrammetry EDAT- 2025/10/28 18:27 MHDA- 2025/10/28 18:28 CRDT- 2025/10/28 14:03 PHST- 2025/09/26 00:00 [revised] PHST- 2025/03/22 00:00 [received] PHST- 2025/10/10 00:00 [accepted] PHST- 2025/10/28 18:28 [medline] PHST- 2025/10/28 18:27 [pubmed] PHST- 2025/10/28 14:03 [entrez] AID - 10.1002/dneu.23011 [doi] PST - ppublish SO - Dev Neurobiol. 2025 Oct;85(4):e23011. doi: 10.1002/dneu.23011. PMID- 41150497 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251028 LR - 20251031 IS - 2075-4663 (Electronic) IS - 2075-4663 (Linking) VI - 13 IP - 10 DP - 2025 Oct 11 TI - Correlation Between Physical Activity and Psychological Problems in Secondary School Students in Spain. LID - 10.3390/sports13100362 [doi] LID - 362 AB - Physical activity (PA) has been identified as a protective factor for adolescent mental health. This study analysed the association between PA and levels of anxiety, depression, and stress among adolescents, considering gender, educational stage, and type of sport. A cross-sectional design was conducted with 106 Spanish secondary school students aged 12-16 years. Data were collected through a self-reported questionnaire on PA participation and the validated DASS-21 scale. Descriptive statistics, chi-square (chi(2)) tests, and adjusted residual analyses were performed. The results showed a significant negative association between PA and anxiety (chi(2) = 303.34, p < 0.01), stress (chi(2) = 310.64, p < 0.01), and depression (chi(2) = 324.32, p < 0.01). Non-athletes presented higher levels of psychological problems compared with active peers, while girls and older students showed greater vulnerability. Adolescents involved in team sports exhibited lower anxiety and stress than those participating in individual sports. In conclusion, higher participation in physical activity, particularly team-based disciplines, is associated with better mental health in adolescents. These findings reinforce the importance of integrating regular physical activity into school contexts to support psychological well-being during adolescence. FAU - Pueyo Gutierrez-Rivas, Pablo AU - Pueyo Gutierrez-Rivas P AD - Health Sciences Faculty, Universidad San Jorge, Autovia A23 km 299, Villanueva de Gallego, 50830 Zaragoza, Spain. FAU - Lozano, Demetrio AU - Lozano D AUID- ORCID: 0000-0001-5443-6721 AD - Health Sciences Faculty, Universidad San Jorge, Autovia A23 km 299, Villanueva de Gallego, 50830 Zaragoza, Spain. FAU - Roso-Moliner, Alberto AU - Roso-Moliner A AUID- ORCID: 0000-0002-5359-1524 AD - Health Sciences Faculty, Universidad San Jorge, Autovia A23 km 299, Villanueva de Gallego, 50830 Zaragoza, Spain. FAU - Albalad-Aiguabella, Rafael AU - Albalad-Aiguabella R AUID- ORCID: 0009-0005-0259-8725 AD - Health Sciences Faculty, Universidad San Jorge, Autovia A23 km 299, Villanueva de Gallego, 50830 Zaragoza, Spain. FAU - Villanueva-Guerrero, Oscar AU - Villanueva-Guerrero O AUID- ORCID: 0000-0001-7952-5798 AD - Health Sciences Faculty, Universidad San Jorge, Autovia A23 km 299, Villanueva de Gallego, 50830 Zaragoza, Spain. FAU - Mainer-Pardos, Elena AU - Mainer-Pardos E AUID- ORCID: 0000-0003-2947-9564 AD - Health Sciences Faculty, Universidad San Jorge, Autovia A23 km 299, Villanueva de Gallego, 50830 Zaragoza, Spain. LA - eng PT - Journal Article DEP - 20251011 PL - Switzerland TA - Sports (Basel) JT - Sports (Basel, Switzerland) JID - 101722684 PMC - PMC12567635 OTO - NOTNLM OT - DASS-21 OT - adolescence OT - educational stage OT - gender OT - individual sports OT - mental health OT - physical activity OT - secondary education OT - team sports COIS- The authors declare no conflicts of interest. EDAT- 2025/10/28 18:27 MHDA- 2025/10/28 18:28 PMCR- 2025/10/11 CRDT- 2025/10/28 12:56 PHST- 2025/08/26 00:00 [received] PHST- 2025/10/06 00:00 [revised] PHST- 2025/10/09 00:00 [accepted] PHST- 2025/10/28 18:28 [medline] PHST- 2025/10/28 18:27 [pubmed] PHST- 2025/10/28 12:56 [entrez] PHST- 2025/10/11 00:00 [pmc-release] AID - sports13100362 [pii] AID - sports-13-00362 [pii] AID - 10.3390/sports13100362 [doi] PST - epublish SO - Sports (Basel). 2025 Oct 11;13(10):362. doi: 10.3390/sports13100362. PMID- 41149061 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251028 LR - 20251030 IS - 2079-9721 (Print) IS - 2079-9721 (Electronic) IS - 2079-9721 (Linking) VI - 13 IP - 10 DP - 2025 Oct 2 TI - Association of Maternal Sociodemographic, Anthropometric, and Lifestyle Factors with Childhood Anthropometric Measures and Anxiety Symptoms: A Nationally Representative Cross-Sectional Study of Preschool-Aged Children in Greece. LID - 10.3390/diseases13100327 [doi] LID - 327 AB - BACKGROUND/OBJECTIVE: Childhood obesity and mental health disorders in preschool-aged children represent critical public health challenges with a rising global prevalence, closely linked to lifestyle behaviors and the family environment. This cross-sectional study aims to investigate the combined influence of maternal sociodemographic, socioeconomic, anthropometric characteristics, and lifestyle factors on the physical and mental health status of preschool-aged children. METHODS: Validated questionnaires were administered to assess dietary habits, psychosocial parameters (depression, anxiety, stress), and sociodemographic, socioeconomic, and anthropometric variables among 200 preschool-aged children and their mothers, who served as the primary informants. RESULTS: Maternal obesity was associated with a higher prevalence of childhood overweight/obesity (36.7% vs. 18.5% in children of non-obese mothers, p = 0.009). Maternal psychological factors, specifically depressive symptoms (B = 0.998, OR = 2.712, 95% CI: 1.222-6.020, p = 0.014) and anxiety (B = 1.676, OR = 5.346, 95% CI: 2.471-11.565, p < 0.001), were independently associated with an increased likelihood of child anxiety. Anthropometric measures, including waist circumference (p = 0.032) and hip circumference (p = 0.031), primarily influenced children's physical health, whereas maternal psychological factors predominantly affected their emotional well-being. CONCLUSIONS: The findings underscore the necessity for targeted interventions focusing on enhancing maternal nutrition and mental health literacy, aiming to promote healthy dietary patterns, physical activity, and lifestyle behaviors. Such interventions are pivotal for preventing childhood obesity and fostering overall well-being at the population level. FAU - Angelakou, Exakousti-Petroula AU - Angelakou EP AD - Department of Food Science and Nutrition, School of Environment, University of Aegean, 81400 Myrina, Greece. FAU - Spyrilioti, Athina AU - Spyrilioti A AD - Department of Statistics and Actuarial-Financial Mathematics, School of Sciences, University of the Aegean, 83200 Samos, Greece. AD - Department of Education, University of Nicosia, 2417 Nicosia, Cyprus. AD - Department of Educational Sciences and Early Childhood Education, University of Patras, 26504 Rio, Greece. FAU - Tsiakara, Maria AU - Tsiakara M AD - Department of Preschool Education Sciences and Educational Design, School of Humanities, University of the Aegean, 85100 Rhodes, Greece. FAU - Vasilakaki, Maria AU - Vasilakaki M AD - Department of Preschool Education Sciences and Educational Design, School of Humanities, University of the Aegean, 85100 Rhodes, Greece. FAU - Giaginis, Constantinos AU - Giaginis C AUID- ORCID: 0000-0003-2878-4831 AD - Department of Food Science and Nutrition, School of Environment, University of Aegean, 81400 Myrina, Greece. LA - eng PT - Journal Article DEP - 20251002 PL - Switzerland TA - Diseases JT - Diseases (Basel, Switzerland) JID - 101636232 PMC - PMC12564222 OTO - NOTNLM OT - childhood anxiety OT - childhood obesity OT - lifestyle factors OT - maternal factors OT - mental health OT - population well-being OT - preschool-aged children COIS- The authors declare no conflicts of interest. EDAT- 2025/10/28 18:27 MHDA- 2025/10/28 18:28 PMCR- 2025/10/02 CRDT- 2025/10/28 12:35 PHST- 2025/09/04 00:00 [received] PHST- 2025/09/27 00:00 [revised] PHST- 2025/09/30 00:00 [accepted] PHST- 2025/10/28 18:28 [medline] PHST- 2025/10/28 18:27 [pubmed] PHST- 2025/10/28 12:35 [entrez] PHST- 2025/10/02 00:00 [pmc-release] AID - diseases13100327 [pii] AID - diseases-13-00327 [pii] AID - 10.3390/diseases13100327 [doi] PST - epublish SO - Diseases. 2025 Oct 2;13(10):327. doi: 10.3390/diseases13100327. PMID- 41147832 OWN - NLM STAT- MEDLINE DCOM- 20261026 LR - 20261026 IS - 1433-7347 (Electronic) IS - 0942-2056 (Linking) VI - 34 IP - 11 DP - 2026 Nov TI - Age- and sex-specific reference values for the Banff Patella Instability Instrument (BPII 2.0) in the German population based on 1309 participants. PG - 4002-4009 LID - 10.1002/ksa.70148 [doi] AB - PURPOSE: The Banff Patella Instability Instrument (BPII 2.0) is a validated patient-reported outcome measure to assess disease-specific quality of life in individuals with lateral patellar instability. This study aimed to establish age- and sex-specific reference values for the German general population and to identify participant-specific factors influencing BPII 2.0 scores. METHODS: Data were collected using quota sampling from 1309 participants via an online panel. The sample was stratified into 12 subgroups (n >/= 100 per subgroup) based on age and sex and weighted to align with German census data. Demographic and health-related data were collected; descriptive statistics and percentiles were used to report age- and sex specific reference values. An analysis of variance (ANOVA) model was built to examine the influence of body mass index (BMI) and comorbidities on BPII 2.0 scores. RESULTS: Males showed higher BPII 2.0 scores compared to females (75.1 +/- 24.0 points vs. 71.0 +/- 26.8 points; p < 0.01). Participants aged 14-30 years showed significantly higher mean scores (79.6 +/- 20.5 points) than those participants >30 years (71.2 +/- 26.4 points) (p < 0.01). ANOVA displayed significant (p < 0.001) decreasing mean scores with an increase in BMI categories (76.0 points; CI 73.9-78.0 points in under/normal weight compared to 64.3 points; CI 60.2-68.3 points in participants with obesity II + III). Participants with self-reported comorbidities showed significantly (p < 0.001) lower mean scores (60.0 points; CI 57.9-62.1 points) compared to persons without comorbidities (82.9 points; CI 80.6-85.2 points). The regression analysis further showed decreasing BPII 2.0 scores with increasing age (-0.24 points per life year). CONCLUSION: This study provides the first age- and sex-stratified reference BPII 2.0 values for the German population. Higher age, female sex, the presence of comorbidities and a higher BMI have a significant negative impact on reference values for the BPII 2.0. LEVEL OF EVIDENCE: Level IV. CI - (c) 2025 European Society of Sports Traumatology, Knee Surgery and Arthroscopy. FAU - Zimmermann, Felix AU - Zimmermann F AUID- ORCID: 0009-0008-4952-2324 AD - ARCUS Sportklinik, Orthopedics and Traumatology, Pforzheim, Germany. AD - BG Klinik Ludwigshafen, Department for Orthopaedics and Trauma Surgery at Heidelberg University, Ludwigshafen, Germany. FAU - Balcarek, Peter AU - Balcarek P AD - ARCUS Sportklinik, Orthopedics and Traumatology, Pforzheim, Germany. AD - Department of Trauma, Hand and Reconstructive Surgery, Departments and Institutes of Surgery, Saarland University, Homburg, Germany. FAU - Giesinger, Johannes Maria AU - Giesinger JM AD - University Hospital of Psychiatry II, Medical University of Innsbruck, Austria. FAU - Pilz, Micha Johannes AU - Pilz MJ AD - University Hospital of Psychiatry II, Medical University of Innsbruck, Austria. FAU - Liebensteiner, Michael AU - Liebensteiner M AD - Orthopadie f. Hufte, Knie & Fuss im Zentrum, Innsbruck, Austria. AD - Privatklinik Kettenbrucke, Innsbruck, Austria. AD - Hospital St. Vinzenz, Zams, Austria. FAU - Dirisamer, Florian AU - Dirisamer F AD - Praxis MOVE, Puchenau, Austria. AD - UMIT Tirol - Private University for Health Sciences and Health Technology, Hall in Tirol, Austria. FAU - Becher, Christoph AU - Becher C AD - ICO - International Center for Orthopedics, ATOS Clinic, Heidelberg, Germany. LA - eng GR - 110/Society for Arthroscopy and Joint-Surgery/ PT - Journal Article DEP - 20251028 PL - Germany TA - Knee Surg Sports Traumatol Arthrosc JT - Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA JID - 9314730 SB - IM MH - Humans MH - Male MH - Female MH - Reference Values MH - Adult MH - Germany MH - Adolescent MH - Young Adult MH - Middle Aged MH - Sex Factors MH - Age Factors MH - Body Mass Index MH - *Joint Instability/diagnosis MH - *Quality of Life MH - *Patient Reported Outcome Measures MH - Aged MH - *Patellar Dislocation/diagnosis OTO - NOTNLM OT - Banff Patella Instability Instrument (BPII 2.0) OT - German general population OT - age- and sex-specific reference values OT - patellar instability OT - patient-reported outcome measure EDAT- 2025/10/28 12:28 MHDA- 2026/10/26 17:31 CRDT- 2025/10/28 09:43 PHST- 2025/10/03 00:00 [revised] PHST- 2025/07/29 00:00 [received] PHST- 2025/10/04 00:00 [accepted] PHST- 2026/10/26 17:31 [medline] PHST- 2025/10/28 12:28 [pubmed] PHST- 2025/10/28 09:43 [entrez] AID - 10.1002/ksa.70148 [doi] PST - ppublish SO - Knee Surg Sports Traumatol Arthrosc. 2026 Nov;34(11):4002-4009. doi: 10.1002/ksa.70148. Epub 2025 Oct 28. PMID- 41147669 OWN - NLM STAT- MEDLINE DCOM- 20261017 LR - 20261017 IS - 1552-3489 (Electronic) IS - 1073-1911 (Linking) VI - 33 IP - 8 DP - 2026 Dec TI - Development and Validation of Ideas of Reference About Body and Appearance Scale (IRBAS) for the Spanish Population. PG - 1412-1428 LID - 10.1177/10731911251379988 [doi] AB - Ideas of Reference (IR) are self-directed attributions about social interactions, where people interpret the behaviors of others as being aimed at them. Particularly, those IRs related to the body and appearance are crucial. This study approaches the need to create and develop an instrument that specifically allows analyzing the Ideas of Reference about Body and Appearance (IRBAS). Pilot studies were conducted, and the IRBAS was subjected to validation in two non-clinical Spanish samples (N = 2,049). Content validity was assessed by an expert panel (N = 6). Exploratory and confirmatory factor analyses were carried out, and the internal consistency and stability of the instrument were evaluated, as well as convergent and known-groups validity. The IRBAS showed a unidimensional structure with high internal consistency and temporal stability. The analyses confirmed its invariance as a function of sex and level of education, and its correlation with measures of body dissatisfaction, dysmorphic concerns, schizotypy, and shame. Moreover, differences were confirmed in the scores of the IRBAS between sexes and between different categories of body mass index. The IRBAS proved to be a reliable and valid tool for the evaluation of IRs about the body and appearance in a non-clinical population. FAU - Ceballos-Munuera, C AU - Ceballos-Munuera C AUID- ORCID: 0000-0002-3197-1710 AD - University of Seville, Spain. FAU - Trinidad-Montero, J AU - Trinidad-Montero J AD - Hospital Sant Joan de Deu, Barcelona, Spain. FAU - Martinez-Cervantes, R AU - Martinez-Cervantes R AD - University of Seville, Spain. FAU - Senin-Calderon, C AU - Senin-Calderon C AD - University of Cadiz, Spain. FAU - Roncero-Sanchis, M AU - Roncero-Sanchis M AD - University of Valencia, Spain. FAU - Rodriguez-Testal, Juan F AU - Rodriguez-Testal JF AUID- ORCID: 0000-0002-7346-5656 AD - University of Seville, Spain. LA - eng PT - Journal Article PT - Validation Study DEP - 20251028 PL - United States TA - Assessment JT - Assessment JID - 9431219 SB - IM MH - Humans MH - Spain MH - Female MH - *Body Image/psychology MH - Male MH - Reproducibility of Results MH - Psychometrics MH - Adult MH - Factor Analysis, Statistical MH - Surveys and Questionnaires MH - Young Adult MH - Middle Aged MH - Pilot Projects MH - Body Satisfaction MH - Adolescent MH - Body Mass Index OTO - NOTNLM OT - Ideas of Reference OT - appearance OT - body concerns OT - body dysmorphia OT - instrument development OT - scale validation COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/10/28 12:29 MHDA- 2026/10/17 23:38 CRDT- 2025/10/28 08:33 PHST- 2026/10/17 23:38 [medline] PHST- 2025/10/28 12:29 [pubmed] PHST- 2025/10/28 08:33 [entrez] AID - 10.1177/10731911251379988 [doi] PST - ppublish SO - Assessment. 2026 Dec;33(8):1412-1428. doi: 10.1177/10731911251379988. Epub 2025 Oct 28. PMID- 41146612 OWN - NLM STAT- MEDLINE DCOM- 20251212 LR - 20251212 IS - 1466-447X (Electronic) IS - 0264-0414 (Linking) VI - 43 IP - 24 DP - 2025 Dec TI - Examining the construct validity and stability of physical literacy in adolescents and its longitudinal relationship with physical activity. PG - 3123-3136 LID - 10.1080/02640414.2025.2574188 [doi] AB - Physical literacy (PL) is a multidimensional construct encompassing motivation, confidence, physical competence, and knowledge/understanding to engage in lifelong physical activity (PA). While widely endorsed, few studies have empirically validated PL. This study aimed to validate the PL construct, examine its stability over time, and assess its role in predicting future PA among adolescents. PL was assessed annually over three time points in 1,081 adolescents (548 girls, 533 boys; mean age = 12.28 +/- 0.33 years at baseline), using validated questionnaires and school-based field tests across four PL domains. A second-order confirmatory factor analysis (CFA) was conducted to identify the latent structure of PL. Longitudinal CFA evaluated the construct's stability, and an autoregressive cross-lagged panel model tested predictive associations between PL and future PA behaviour. The second-order CFA confirmed the multidimensional structure of PL. Longitudinal CFA supported the construct's stability, with partial scalar invariance indicating a consistent model across time. The autoregressive cross-lagged panel model revealed that PL significantly predicted PA engagement in subsequent years. This study empirically validates PL as a stable and multidimensional construct, demonstrating its predictive value for adolescent PA. Findings support PL as a crucial determinant of health and underscore the importance of fostering PL through targeted youth interventions and PA programmes. FAU - Park, Junhyuk AU - Park J AUID- ORCID: 0000-0001-9043-6497 AD - Department of Kinesiology, University of Georgia Athens, GA, USA. FAU - Yun, Sanga AU - Yun S AUID- ORCID: 0000-0002-6652-4603 AD - Department of Kinesiology, University of Georgia Athens, GA, USA. FAU - Huhtiniemi, Mikko AU - Huhtiniemi M AUID- ORCID: 0000-0002-1643-2671 AD - Faculty of Sport and Health Sciences, University of Jyvaskyla Jyvaskyla, Finland. FAU - Grasten, Arto AU - Grasten A AUID- ORCID: 0000-0002-9598-7949 AD - Physical Education Department, United Arab Emirates University, Al Ain, UAE. FAU - Jaakkola, Timo AU - Jaakkola T AUID- ORCID: 0000-0003-1227-2460 AD - Faculty of Sport and Health Sciences, University of Jyvaskyla Jyvaskyla, Finland. FAU - Yli-Piipari, Sami AU - Yli-Piipari S AUID- ORCID: 0000-0002-8623-1322 AD - Department of Kinesiology, University of Georgia Athens, GA, USA. LA - eng PT - Journal Article PT - Validation Study DEP - 20251028 PL - England TA - J Sports Sci JT - Journal of sports sciences JID - 8405364 SB - IM MH - Humans MH - Male MH - Female MH - Adolescent MH - Longitudinal Studies MH - *Exercise/psychology MH - Motivation MH - Surveys and Questionnaires MH - Child MH - *Health Literacy MH - Factor Analysis, Statistical MH - *Health Knowledge, Attitudes, Practice MH - Reproducibility of Results OTO - NOTNLM OT - Health determinant OT - active lifestyle OT - confirmatory factor analysis OT - physical education OT - structural equation modeling EDAT- 2025/10/28 06:29 MHDA- 2025/12/12 17:54 CRDT- 2025/10/28 03:52 PHST- 2025/12/12 17:54 [medline] PHST- 2025/10/28 06:29 [pubmed] PHST- 2025/10/28 03:52 [entrez] AID - 10.1080/02640414.2025.2574188 [doi] PST - ppublish SO - J Sports Sci. 2025 Dec;43(24):3123-3136. doi: 10.1080/02640414.2025.2574188. Epub 2025 Oct 28. PMID- 41146477 OWN - NLM STAT- MEDLINE DCOM- 20260125 LR - 20260125 IS - 1744-411X (Electronic) IS - 1380-3395 (Linking) VI - 48 IP - 1 DP - 2026 Feb TI - A sensor-based gait measure for identifying invalid performance in simulated mTBI: an experimental proof of concept. PG - 49-63 LID - 10.1080/13803395.2025.2579175 [doi] AB - INTRODUCTION: Psychologists are increasingly called upon to make complex decisions affected by an individuals' effort, relying at least in part on performance validity testing. Because most measures of performance validity are cognitively-based, there is utility in exploring alternative assessment modalities. Recently, an accelerometer-based gait assessment has been validated for use with sports concussion outcomes. The current, preregistered study serves as an experimental proof of concept utilizing the same measure of gait to differentiate individuals instructed to simulate a mild Traumatic Brain Injury (mTBI) from those with a sports-related mTBI (concussion). METHODS: 106 uninjured simulators were compared to 75 individuals with sports-related clinical mTBI and 75 normal controls. All participants completed an accelerometer-based measure of gait known as the BioKinetoGraph (BKG) as a part of a larger battery designed to assess for concussion in athletes. RESULTS: Unique abnormalities in the gait domains of Stride (timing), Power, Balance, and Symmetry were observed among simulating participants compared to mTBI participants. Classification analysis yielded several variables with fair to acceptable discriminability, and a multiple variable model with discriminability at the high end of the acceptable range (AUC = 0.78). CONCLUSIONS: Findings offer preliminary support for the ability of an automated gait-based measure to capture invalid performance and inform investigations regarding effort. These experimental findings represent a first step in exploring the potential clinical utility of the BKG as a measure of performance validity. FAU - Price, Jordan AU - Price J AD - Department of Psychology, University of North Carolina Wilmington, Wilmington, NC, USA. FAU - Lecci, Len AU - Lecci L AD - Department of Psychology, University of North Carolina Wilmington, Wilmington, NC, USA. LA - eng PT - Journal Article DEP - 20251027 PL - England TA - J Clin Exp Neuropsychol JT - Journal of clinical and experimental neuropsychology JID - 8502170 SB - IM MH - Humans MH - *Brain Concussion/diagnosis/physiopathology/complications MH - Male MH - Female MH - Adult MH - Young Adult MH - *Athletic Injuries/diagnosis/complications/physiopathology MH - *Accelerometry/instrumentation/methods MH - *Gait Disorders, Neurologic/diagnosis/etiology MH - Proof of Concept Study MH - *Gait Analysis/instrumentation/methods MH - Adolescent OTO - NOTNLM OT - Neuromotor OT - concussion OT - invalid performance OT - mTBI OT - performance validity EDAT- 2025/10/28 06:29 MHDA- 2026/01/26 00:33 CRDT- 2025/10/28 02:23 PHST- 2026/01/26 00:33 [medline] PHST- 2025/10/28 06:29 [pubmed] PHST- 2025/10/28 02:23 [entrez] AID - 10.1080/13803395.2025.2579175 [doi] PST - ppublish SO - J Clin Exp Neuropsychol. 2026 Feb;48(1):49-63. doi: 10.1080/13803395.2025.2579175. Epub 2025 Oct 27. PMID- 41146139 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 25 IP - 1 DP - 2025 Oct 27 TI - C-reactive protein-to-albumin ratio as a predictor of 28-day mortality in critically ill pediatric patients: a retrospective cohort study. PG - 864 LID - 10.1186/s12887-025-06261-9 [doi] LID - 864 AB - OBJECTIVE: This large-scale real-world study aimed to evaluate whether the C-reactive protein-to-albumin ratio (CAR), an indicator of systemic inflammation and nutritional status, predicts 28-day mortality in critically ill pediatric patients. DESIGN: Retrospective cohort study. METHODS: We analyzed data from 8,000 children admitted to a tertiary pediatric intensive care unit (PICU) in China between 2010 and 2019. CAR was calculated using initial CRP and albumin levels upon admission. Patients were stratified into quartiles based on CAR values. The primary outcome was 28-day all-cause mortality; in-hospital mortality was a secondary outcome. Multivariable Cox regression and Kaplan-Meier survival analyses were performed, along with subgroup analyses to validate robustness. RESULTS: Higher CAR levels were significantly associated with increased 28-day mortality. Patients in the highest CAR quartile had a hazard ratio of 1.51 (95% CI: 1.07-2.13; p = 0.018) compared with the lowest quartile. The fully adjusted model including CAR achieved an AUC of 0.820 (95% CI: 0.798-0.843), indicating good discriminatory ability. Kaplan-Meier curves confirmed reduced survival in the high CAR group (p = 0.0042). The association remained consistent across all subgroups. CONCLUSION: CAR is significantly associated with short-term mortality in critically ill children. As a low-cost, easily accessible biomarker, CAR may serve as a valuable early risk stratification tool in real-world pediatric intensive care settings. FAU - Chang, Jie AU - Chang J AUID- ORCID: 0009-0008-7867-3252 AD - Department of Respiratory Medicine, Children's Hospital of Shanxi Province, Taiyuan, China. changjie@stu.hebmu.edu.cn. FAU - Zhang, Xiaojuan AU - Zhang X AD - Department of Respiratory Medicine, Children's Hospital of Shanxi Province, Taiyuan, China. FAU - Wang, Wei AU - Wang W AD - Department of Respiratory Medicine, Children's Hospital of Shanxi Province, Taiyuan, China. FAU - Liu, Liping AU - Liu L AD - Department of Respiratory Medicine, Children's Hospital of Shanxi Province, Taiyuan, China. liuliping654321@126.com. LA - eng PT - Journal Article DEP - 20251027 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 RN - 9007-41-4 (C-Reactive Protein) RN - 0 (Biomarkers) RN - 0 (Serum Albumin) SB - IM MH - Humans MH - Retrospective Studies MH - *Critical Illness/mortality MH - *C-Reactive Protein/analysis/metabolism MH - Female MH - Infant MH - Male MH - Child, Preschool MH - Intensive Care Units, Pediatric MH - Biomarkers/blood MH - Hospital Mortality MH - Child MH - *Serum Albumin/analysis MH - Predictive Value of Tests MH - China/epidemiology MH - Kaplan-Meier Estimate PMC - PMC12557986 OTO - NOTNLM OT - 28-day mortality OT - Albumin OT - C-reactive protein-to-albumin ratio OT - Critically ill pediatric patients OT - Pediatric intensive care unit COIS- Declarations. Ethics approval and consent to participate: This study was conducted using the Pediatric Intensive Care (PIC) database, which includes de-identified patient data from the Children's Hospital, Zhejiang University School of Medicine between 2010 and 2019. The PIC database was approved by the Institutional Review Board of the Children's Hospital, Zhejiang University School of Medicine (Approval number: 2019_IRB_052). The use of this publicly available, de-identified dataset for secondary analysis qualified for exemption from further ethical approval and informed consent. All procedures were performed in accordance with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/10/28 06:30 MHDA- 2026/06/27 04:10 PMCR- 2025/10/27 CRDT- 2025/10/28 00:58 PHST- 2025/07/13 00:00 [received] PHST- 2025/09/29 00:00 [accepted] PHST- 2026/06/27 04:10 [medline] PHST- 2025/10/28 06:30 [pubmed] PHST- 2025/10/28 00:58 [entrez] PHST- 2025/10/27 00:00 [pmc-release] AID - 10.1186/s12887-025-06261-9 [pii] AID - 6261 [pii] AID - 10.1186/s12887-025-06261-9 [doi] PST - epublish SO - BMC Pediatr. 2025 Oct 27;25(1):864. doi: 10.1186/s12887-025-06261-9. PMID- 41146134 OWN - NLM STAT- MEDLINE DCOM- 20251028 LR - 20251031 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Oct 27 TI - Burden of migraine among university students in the Middle East and North Africa: a cross-sectional study of prevalence, mental health comorbidities, and disability. PG - 3605 LID - 10.1186/s12889-025-24293-9 [doi] LID - 3605 AB - BACKGROUND: Migraine is a prevalent and debilitating neurological condition that significantly impact the academic lives of university students. Despite its high prevalence, migraine is often underreported, underdiagnosed, and inadequately managed particularly in the Middle East and North Africa (MENA) region. OBJECTIVE: This study aimed to determine the prevalence of migraine identified by screening, related disability, and psychological comorbidities among university students in the MENA region. METHODS: We conducted a multinational cross-sectional study among university students in 11 low and middle-income countries in the MENA region, using an anonymous self-administered questionnaire. The convenience and snowball sampling methods were used. This study utilized a validated questionnaire to collect data on migraine frequency, characteristics, disability, associated depression, anxiety, and triggers. RESULTS: The present study screened a total of 5,954 students for migraine. Of them, 26.1% screened positive for migraine. Iraq had the highest prevalence 38.9%, followed by Algeria 31.5%, and the lowest was in Egypt 19.9% and Morocco 18.4%. Common migraine triggers included sleeping disturbances 59.7%, noise 47.4%, and sun exposure 45.6%. Among positive cases, 23.2% had severe disability, 29.9% had moderate anxiety, and 72.5% had severe depression. The main predictors of migraine were females, older age, and non-medical field university students. Adequate hydration, sufficient sleep, regular physical activity, higher fluid intake, and extended study hours were associated with a lower risk of migraine. Daily caffeine consumption was associated with increased migraine risk. A modest negative relationship was found between academic success and migraine disability score. CONCLUSION: Our results demonstrated a high proportion of students screened positive for migraine with significant associations to depression, anxiety, and disability. These findings highlight the need for targeted interventions to increase awareness about migraine-related comorbidities, screening programs to help in early detection, and lifestyle modification. Universities should develop and implement coping strategies to support affected students. CI - (c) 2025. The Author(s). FAU - Samir, Ahmed Amir AU - Samir AA AUID- ORCID: 0009-0003-3264-031X AD - Faculty of Medicine, Al-Azhar University, Nasr city, Cairo, Egypt. FAU - Elgammal, Ahmed Samy AU - Elgammal AS AUID- ORCID: 0009-0000-0087-7222 AD - Faculty of Medicine, Tanta University, Tanta, Egypt. FAU - Alieldeen, Abdelrhman Mahmoud AU - Alieldeen AM AUID- ORCID: 0009-0004-7335-2960 AD - Faculty of Medicine, Delta University for Science and Technology, Dakahlia, Egypt. FAU - Allam, Eman Gomaa AU - Allam EG AUID- ORCID: 0009-0003-4070-2760 AD - Faculty of Medicine for Girls, Al-Azhar University, Nasr City, Cario, Egypt. FAU - Ketata, Imen AU - Ketata I AUID- ORCID: 0000-0002-3057-8028 AD - Neurology Department of Gabes, Faculty of Medicine, University Hospital of Gabes, University of Sfax, Sfax, Tunisia. FAU - Ellouz, Emna AU - Ellouz E AUID- ORCID: 0000-0002-2180-9445 AD - Neurology Department of Gabes, Faculty of Medicine, University Hospital of Gabes, University of Sfax, Sfax, Tunisia. FAU - Hekal, Rawan Gameel AU - Hekal RG AUID- ORCID: 0009-0002-6305-6020 AD - Faculty of Medicine, Menoufia University, Menoufia, Egypt. FAU - Salameh, Hossam AU - Salameh H AUID- ORCID: 0009-0009-5346-9973 AD - Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine. FAU - Didda, Nasrouha AU - Didda N AUID- ORCID: 0009-0007-7147-1888 AD - Department of Clinical Laboratory Diagnostics, Faculty of Medicine, Astrakhan University, Astrakhan, Russia. FAU - Kebir, Naima AU - Kebir N AD - Faculty of Medicine, Oran1 University, Oran, Algeria. FAU - Selim, Abderrhman Abdelfattah AU - Selim AA AUID- ORCID: 0009-0008-0935-4645 AD - Faculty of Medicine, Alexandria University, Alexandria, Egypt. FAU - Atshan, Hussein Zeyad AU - Atshan HZ AUID- ORCID: 0009-0001-9117-4481 AD - Faculty of Medicine, University of Baghdad, Baghdad, Iraq. FAU - Bashir, Aiman Awad AU - Bashir AA AUID- ORCID: 0009-0006-6702-1609 AD - Faculty of Medicine, University of Khartoum, Khartoum, Sudan. FAU - Kouzeiha, Riad Azzam AU - Kouzeiha RA AUID- ORCID: 0009-0003-6512-8072 AD - Faculty of Medical Sciences, Lebanese University, Hadath Campus, Beirut, Lebanon. FAU - Alayiab, Hanadi AU - Alayiab H AUID- ORCID: 0009-0008-5535-9252 AD - Faculty of Human Medicine, Benghazi University, Benghazi, Libya. FAU - Kabbash, Ibrahim Ali AU - Kabbash IA AUID- ORCID: 0000-0003-2555-1442 AD - Professor of Public Health & Community Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt. Ibrahim.kabbash@med.tanta.edu.eg. CN - Migraine collaborative group LA - eng PT - Journal Article DEP - 20251027 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - *Migraine Disorders/epidemiology/psychology MH - Male MH - Middle East/epidemiology MH - *Students/psychology/statistics & numerical data MH - Africa, Northern/epidemiology MH - Universities MH - Prevalence MH - Young Adult MH - Adult MH - Comorbidity MH - *Persons with Disabilities/statistics & numerical data MH - Surveys and Questionnaires MH - *Mental Disorders/epidemiology MH - Adolescent MH - *Cost of Illness MH - Depression/epidemiology MH - Anxiety/epidemiology PMC - PMC12557868 OTO - NOTNLM OT - Academic life OT - MENA region OT - Mental health OT - Migraine OT - Prevalence OT - University students COIS- Declarations. Ethics approval and consent to participate: This study followed the principles of the Declaration of Helsinki (1964, last revised in 2013) in its entirety. Participation in this study was voluntary, and participants provided their informed consent electronically prior to completing the survey after a thorough description of the study that emphasized their anonymity and confidentiality. Ethical approval was obtained from the institutional review board committee (IRB) at Faculty of Medicine, Tanta University, (Approval number 36264PR848/9/24). Consent for publication: Not applicable Competing interests: The authors declare no competing interests. FIR - Ahmed, Amani IR - Ahmed A FIR - Amin, Mohammed Namiq IR - Amin MN FIR - Brhaish, Mohammed IR - Brhaish M FIR - Alzedaar, Jubran Khaled IR - Alzedaar JK FIR - Elnur, Mizab Akasha IR - Elnur MA FIR - Bawazeer, Mooaz IR - Bawazeer M FIR - Mohammed, Raheb IR - Mohammed R FIR - Alghazal, Abubaker IR - Alghazal A FIR - Iwidat, Basmala IR - Iwidat B FIR - Asad, Ahmad IR - Asad A FIR - Jawabreh, Dawod IR - Jawabreh D FIR - Abdelaziz, Omar IR - Abdelaziz O FIR - Salih, Amira IR - Salih A FIR - Al-Dwaik, Rahaf IR - Al-Dwaik R FIR - Salah, Nabat Ali IR - Salah NA FIR - Eladawi, Safir IR - Eladawi S FIR - Al-Fadhel, Sarah IR - Al-Fadhel S FIR - Bawazir, Salem IR - Bawazir S FIR - Aramin, Mohammed IR - Aramin M FIR - Shalash, Mohammed IR - Shalash M FIR - Elaagib, Amna IR - Elaagib A FIR - El-QaisiBurden Of Migraine Among University Students In Middle, Shatha IR - El-QaisiBurden Of Migraine Among University Students In Middle S FIR - Shehimi, Hadi IR - Shehimi H FIR - Ali, Razan Abu IR - Ali RA FIR - Thouqan, Lana IR - Thouqan L FIR - Qarqash, Mohammad IR - Qarqash M FIR - Hejazi, Asmaa Albasha IR - Hejazi AA FIR - Amro, Balqees IR - Amro B FIR - Rajha, Rafi IR - Rajha R FIR - Alzubaidi, Abdullah IR - Alzubaidi A FIR - Alfdool, Amani IR - Alfdool A FIR - Ahmed, Fatma Abdelsalam IR - Ahmed FA FIR - Khliefat, Dina IR - Khliefat D FIR - Haidri, Rouqia Naeem IR - Haidri RN FIR - Haj, Siwar IR - Haj S FIR - Al-Fhrnawie, Haneen S IR - Al-Fhrnawie HS FIR - Al-Fhrnawie, Diyar S IR - Al-Fhrnawie DS FIR - Hamici, Safia IR - Hamici S FIR - Fatma, Kheloufi Yassmine IR - Fatma KY FIR - Kessouri, Kessouri IR - Kessouri K EDAT- 2025/10/28 06:30 MHDA- 2025/10/28 06:31 PMCR- 2025/10/27 CRDT- 2025/10/28 00:58 PHST- 2025/03/14 00:00 [received] PHST- 2025/08/05 00:00 [accepted] PHST- 2025/10/28 06:31 [medline] PHST- 2025/10/28 06:30 [pubmed] PHST- 2025/10/28 00:58 [entrez] PHST- 2025/10/27 00:00 [pmc-release] AID - 10.1186/s12889-025-24293-9 [pii] AID - 24293 [pii] AID - 10.1186/s12889-025-24293-9 [doi] PST - epublish SO - BMC Public Health. 2025 Oct 27;25(1):3605. doi: 10.1186/s12889-025-24293-9. PMID- 41145302 OWN - NLM STAT- MEDLINE DCOM- 20251027 LR - 20251027 IS - 1651-2014 (Electronic) IS - 1103-8128 (Linking) VI - 32 IP - 1 DP - 2025 Jan TI - Psychometric evaluation of the web-based physical participation instrument ActiveYou II in children and adults with disabilities. PG - 2576669 LID - 10.1080/11038128.2025.2576669 [doi] AB - BACKGROUND: Ensuring inclusive participation in daily physical activities is crucial and valid and reliable instruments are needed. AIM: To evaluate the test-retest reliability and internal consistency of the self-reported web-based physical participation instrument, ActiveYou II. MATERIAL AND METHODS: Reliability was examined in 41 children (mean age 10,5 years), and 41 adults (mean age 49 years) with disabilities using intraclass correlation coefficients (ICC), Kappa statistics, percentage of absolute agreement, and Cronbach's alpha. RESULTS: The test-retest reliability was good for the participation frequency scores (ICC; 0.66 to 0.95) and moderate for the skill-competency and involvement scores (ICC; 0.43 to 0.89). The alpha values for internal consistency were acceptable for the frequency (alpha = 0.749), skill competency (alpha = 0.833), and involvement scores (alpha = 0.795). CONCLUSIONS: ActiveYou II demonstrated good psychometric properties, indicating its potential to inform intervention planning and enhance service provision for individuals with disabilities. Lower reliability in skill competency and involvement scores suggests these factors are transient, varying with experiences, well-being, and mood. ActiveYou II maps and evaluates the interaction between individual and environmental factors, enhancing understanding of participation in physical activities. SIGNIFICANT: Leveraging insights from ActiveYou II, stakeholders can enhance participation in physical activities and well-being for individuals with disabilities, thereby fostering a more inclusive society. FAU - Ullenhag, Anna AU - Ullenhag A AUID- ORCID: 0009-0004-4159-413X AD - Department of Physiotherapy, Malardalens University, Academy of Health, Care and Welfare, Vasteras, Sweden. AD - Beitostolen Healthsports center, Beitostolen, Norway. FAU - Gjessing, Berit AU - Gjessing B AD - Beitostolen Healthsports center, Beitostolen, Norway. FAU - Baksjoberget, Per Enok AU - Baksjoberget PE AD - Vestfold Hospital Trust, Tonsberg, Norway. LA - eng PT - Journal Article DEP - 20251027 PL - Switzerland TA - Scand J Occup Ther JT - Scandinavian journal of occupational therapy JID - 9502210 SB - IM MH - Humans MH - Psychometrics MH - Male MH - Female MH - Reproducibility of Results MH - Child MH - Adult MH - Middle Aged MH - *Persons with Disabilities/psychology MH - *Internet MH - Adolescent MH - *Exercise MH - Activities of Daily Living MH - Self Report MH - Social Participation MH - *Children with Disabilities MH - Disability Evaluation MH - Young Adult OTO - NOTNLM OT - Disabled persons OT - involvement OT - measurement OT - physical activity OT - reliability EDAT- 2025/10/28 00:26 MHDA- 2025/10/28 00:27 CRDT- 2025/10/27 22:12 PHST- 2025/10/28 00:27 [medline] PHST- 2025/10/28 00:26 [pubmed] PHST- 2025/10/27 22:12 [entrez] AID - 10.1080/11038128.2025.2576669 [doi] PST - ppublish SO - Scand J Occup Ther. 2025 Jan;32(1):2576669. doi: 10.1080/11038128.2025.2576669. Epub 2025 Oct 27. PMID- 41144955 OWN - NLM STAT- MEDLINE DCOM- 20251027 LR - 20260908 IS - 2291-5222 (Electronic) IS - 2291-5222 (Linking) VI - 13 DP - 2025 Oct 27 TI - A Culturally and Linguistically Tailored Intervention to Improve Diabetes-Related Outcomes in Chinese Americans With Type 2 Diabetes: Pilot Randomized Controlled Trial. PG - e78036 LID - 10.2196/78036 [doi] LID - e78036 AB - BACKGROUND: Chinese Americans with type 2 diabetes (T2D) face many linguistic, cultural, and social determinants of health-related barriers to accessing evidence-based diabetes interventions. Our team developed the culturally and linguistically tailored Chinese American Research and Education (CARE) program to provide evidence-based diabetes education and support to this group and demonstrated the feasibility, acceptability, and potential efficacy of the intervention on improving hemoglobin A(1c) levels. However, it remains unclear whether the CARE program also improves diabetes self-efficacy and psychosocial outcomes in the same study sample. OBJECTIVE: This is a secondary analysis to examine the potential efficacy of the CARE program on secondary outcomes, including diabetes self-efficacy, self-care activities, beliefs in diabetes self-care activities, and diabetes distress among Chinese Americans with T2D. METHODS: A 2-arm, pilot randomized controlled trial was conducted to evaluate the CARE program between March 1, 2021, and April 21, 2023. The trial included 60 Chinese Americans aged 18 to 70 years who had a diagnosis of T2D and a baseline hemoglobin A(1c) level of 7% or higher. Participants were recruited from various health care settings in New York City, including community health centers, private primary care providers, and NYU Langone Health and its affiliates, and were randomly assigned to either the CARE intervention group (n=30) or a waitlist control group (n=30). The intervention consisted of 2 culturally and linguistically tailored educational videos per week for 12 weeks, covering diabetes self-care topics such as healthy eating, physical activity, and medication adherence. These videos were delivered via the WeChat app. In addition, community health workers provided support calls to assist them in setting goals, problem-solving, and addressing social determinants of health barriers every 2 weeks. Secondary outcomes included patient self-reported diabetes self-efficacy, self-care activities, beliefs in diabetes self-care activities, and diabetes distress. Outcomes were assessed at baseline, 3 months, and 6 months. RESULTS: Participants had a mean age of 54.3 (SD 11.5) years and 62% (37/60) were male, 78% (47/60) were married, 58% (35/60) were employed, 70% (42/60) had a high school education or lower, and 88% (53/60) reported limited English proficiency. Intervention participants demonstrated statistically significant improvements in self-efficacy at 3 months (estimated difference in change: 8.47; 95% CI 2.44-14.5; adjusted P=.02), diabetes distress at 6 months (estimated difference in change: -0.43; 95% CI -0.71 to -0.15; adjusted P=.009), and adherence to a healthy diet at both 3 months (estimated difference in change: 1.61; 95% CI 0.46-2.75; adjusted P=.02) and 6 months (estimated difference in change: 1.64; 95% CI 0.48-2.81; adjusted P=.02). CONCLUSIONS: The culturally and linguistically tailored intervention showed promise in improving self-efficacy and diabetes self-care activities among Chinese Americans with T2D, warranting validation through a large-scale randomized controlled trial. TRIAL REGISTRATION: ClinicalTrials.gov NCT03557697; https://clinicaltrials.gov/study/NCT03557697. CI - (c)Jing Liu, Jiepin Cao, Yun Shi, Mary Ann Sevick, Nadia Islam, Naumi Feldman, Huilin Li, Chan Wang, Yanan Zhao, Kosuke Tamura, Natalie Levy, Nan Jiang, Ziqiang Zhu, Yulin Wang, Jia Hong, Lu Hu. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org), 27.10.2025. FAU - Liu, Jing AU - Liu J AUID- ORCID: 0000-0002-3266-0690 AD - Department of Population Health, NYU Langone Health, New York City, NY, United States. FAU - Cao, Jiepin AU - Cao J AUID- ORCID: 0000-0002-0117-5756 AD - Department of Population Health, NYU Langone Health, New York City, NY, United States. FAU - Shi, Yun AU - Shi Y AUID- ORCID: 0000-0003-1936-072X AD - Department of Population Health, NYU Langone Health, New York City, NY, United States. FAU - Sevick, Mary Ann AU - Sevick MA AUID- ORCID: 0000-0002-5482-7535 AD - Department of Population Health, NYU Langone Health, New York City, NY, United States. FAU - Islam, Nadia AU - Islam N AUID- ORCID: 0000-0003-1470-2073 AD - Department of Population Health, NYU Langone Health, New York City, NY, United States. FAU - Feldman, Naumi AU - Feldman N AUID- ORCID: 0000-0003-0548-8677 AD - Charles B. Wang Community Health Center, New York City, NY, United States. FAU - Li, Huilin AU - Li H AUID- ORCID: 0000-0002-8288-7068 AD - Department of Population Health, NYU Langone Health, New York City, NY, United States. FAU - Wang, Chan AU - Wang C AUID- ORCID: 0000-0002-1718-5414 AD - Department of Population Health, NYU Langone Health, New York City, NY, United States. FAU - Zhao, Yanan AU - Zhao Y AUID- ORCID: 0009-0002-6033-3168 AD - Department of Population Health, NYU Langone Health, New York City, NY, United States. FAU - Tamura, Kosuke AU - Tamura K AUID- ORCID: 0000-0002-4920-2856 AD - Division of Intramural Research, National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD, United States. FAU - Levy, Natalie AU - Levy N AUID- ORCID: 0000-0003-2956-5876 AD - Department of Medicine, NYU Langone Health, New York City, NY, United States. FAU - Jiang, Nan AU - Jiang N AUID- ORCID: 0000-0003-0714-750X AD - Department of Population Health, NYU Langone Health, New York City, NY, United States. FAU - Zhu, Ziqiang AU - Zhu Z AUID- ORCID: 0000-0002-5328-636X AD - Wellsure Medical Practice, New York City, NY, United States. FAU - Wang, Yulin AU - Wang Y AUID- ORCID: 0009-0008-3020-7607 AD - Yulin Medicine PLLC, New York City, NY, United States. FAU - Hong, Jia AU - Hong J AUID- ORCID: 0009-0006-7682-3849 AD - Hong Jia Medical PC, New York City, NY, United States. FAU - Hu, Lu AU - Hu L AUID- ORCID: 0000-0001-6465-6779 AD - Department of Population Health, NYU Langone Health, New York City, NY, United States. LA - eng SI - ClinicalTrials.gov/NCT03557697 GR - P50 MD017356/MD/NIMHD NIH HHS/United States GR - R00 MD012811/MD/NIMHD NIH HHS/United States GR - R01 MD017579/MD/NIMHD NIH HHS/United States GR - U54 MD000538/MD/NIMHD NIH HHS/United States GR - P30 DK111022/DK/NIDDK NIH HHS/United States GR - ZIA MD000020/ImNIH/Intramural NIH HHS/United States GR - K99 MD012811/MD/NIMHD NIH HHS/United States GR - R18 HS029813/HS/AHRQ HHS/United States PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, N.I.H., Intramural DEP - 20251027 PL - Canada TA - JMIR Mhealth Uhealth JT - JMIR mHealth and uHealth JID - 101624439 RN - 0 (Glycated Hemoglobin) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/psychology/therapy/ethnology MH - Male MH - Female MH - Middle Aged MH - *Asian/statistics & numerical data/psychology MH - Pilot Projects MH - Adult MH - Aged MH - New York City MH - Self Care/methods/psychology MH - Glycated Hemoglobin/analysis MH - Self Efficacy MH - Adolescent MH - Outcome Assessment, Health Care/statistics & numerical data MH - Culturally Competent Care/standards PMC - PMC12603588 OTO - NOTNLM OT - community health worker OT - diabetes self-management OT - health equity OT - immigrant health OT - minority health OT - mobile health OT - social determinants of health OT - social media OT - social needs OT - type 2 diabetes COIS- Conflicts of Interest: LH reports holding stock in Tencent Holdings Limited. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. All of the other authors have no conflicts of interest to declare. EDAT- 2025/10/27 18:26 MHDA- 2025/10/27 18:27 PMCR- 2025/10/27 CRDT- 2025/10/27 16:53 PHST- 2025/05/25 00:00 [received] PHST- 2025/09/09 00:00 [accepted] PHST- 2025/08/08 00:00 [revised] PHST- 2025/10/27 18:27 [medline] PHST- 2025/10/27 18:26 [pubmed] PHST- 2025/10/27 16:53 [entrez] PHST- 2025/10/27 00:00 [pmc-release] AID - v13i1e78036 [pii] AID - 10.2196/78036 [doi] PST - epublish SO - JMIR Mhealth Uhealth. 2025 Oct 27;13:e78036. doi: 10.2196/78036. PMID- 41144474 OWN - NLM STAT- MEDLINE DCOM- 20260117 LR - 20260117 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 10 DP - 2025 TI - Adolescents' attitudes towards healthy eating: A scale development study. PG - e0334945 LID - 10.1371/journal.pone.0334945 [doi] LID - e0334945 AB - The aim of this study is to develop a measurement tool that can reliably and validly measure adolescent individuals' attitudes toward healthy eating. The study group consisted of 1,006 individuals, including 495 males and 511 females, aged between 11 and 17 years. In this study, an exploratory sequential design was applied. A semi-structured interview form was used to create the item pool, and compositions were written. The "Davis Technique" was employed to assess the content validity of the items. For data analysis, SPSS 25.0 was used for EFA and reliability analysis, and Lisrel 8.7 was utilized for CFA. Based on the result of EFA, a structure consisting of 4 factors and 18 items was formed. The total variance explained is 59.05. According to CFA analysis, factor loadings range from .43 to .81, and X2/df = 1.65, RMSEA = .040 were found. Furthermore, the NFI, NNFI, PNFI, CFI, IFI, GFI, AGFI, PGFI, and RFI fit indices were found to be excellent and within the good range. In the analysis of the lower and upper groups of the scale (27%), statistically significant differences were observed in all items (p < .01). To test the reliability of the scale, Cronbach's Alpha, Spearman-Brown (Split-half), and Guttman Lambda-6 coefficients were examined. The scale sub-dimension correlations ranged from .526 to .129. In conclusion, the developed scale demonstrates that it can validly and reliably measure adolescents' attitudes toward healthy eating. CI - Copyright: (c) 2025 Eskil et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Eskil, Remzi AU - Eskil R AUID- ORCID: 0000-0001-8722-993X AD - Faculty of Sport Sciences, Gazi University, Turkey. FAU - Eskil, Kezban Gulsen AU - Eskil KG AD - Faculty of Sport Sciences, Gazi University, Turkey. FAU - Yarim, Imdat AU - Yarim I AD - Faculty of Sport Sciences, Gazi University, Turkey. LA - eng PT - Journal Article PT - Validation Study DEP - 20251027 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - *Diet, Healthy/psychology/statistics & numerical data MH - *Attitude to Health MH - *Psychology, Adolescent/statistics & numerical data MH - Reproducibility of Results MH - *Psychometrics/methods MH - Surveys and Questionnaires MH - Interviews as Topic MH - Pilot Projects MH - Humans MH - Male MH - Female MH - Child MH - Adolescent PMC - PMC12558527 COIS- The authors have declared that no competing interests exist. EDAT- 2025/10/27 18:26 MHDA- 2025/10/27 18:27 PMCR- 2025/10/27 CRDT- 2025/10/27 13:43 PHST- 2025/06/07 00:00 [received] PHST- 2025/10/03 00:00 [accepted] PHST- 2025/10/27 18:27 [medline] PHST- 2025/10/27 18:26 [pubmed] PHST- 2025/10/27 13:43 [entrez] PHST- 2025/10/27 00:00 [pmc-release] AID - PONE-D-25-28795 [pii] AID - 10.1371/journal.pone.0334945 [doi] PST - epublish SO - PLoS One. 2025 Oct 27;20(10):e0334945. doi: 10.1371/journal.pone.0334945. eCollection 2025. PMID- 41144395 OWN - NLM STAT- MEDLINE DCOM- 20251027 LR - 20260925 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 10 DP - 2025 TI - Normative value of upper extremity Y balance test in healthy subjects aged between 18 and 36 years from South India: A cross-sectional study. PG - e0335443 LID - 10.1371/journal.pone.0335443 [doi] LID - e0335443 AB - INTRODUCTION: The Upper Quarter Y Balance Test (UQYBT) is a validated tool used to assess unilateral upper extremity function in a closed kinetic chain. It evaluates parameters such as mobility, stability, and injury risk, and can inform rehabilitation planning. Normative data have been well established for adolescent and active adult populations in the United States. This study aims to establish normative UQYBT values for healthy adults aged 18-36 years in the Indian subcontinent. METHODS: A total of 190 healthy young adults (95 males and 95 females) aged 18-36 years who met the eligibility criteria were included. Baseline demographic data-age, height, weight, body mass index (BMI), and limb length-were collected. Participants performed the UQ-YBT by reaching in the inferolateral, medial, and superolateral directions using the three-reach box. Average reach distances were calculated for each limb, and composite scores (CS) were normalized using arm length. RESULTS: Age- and sex-specific reference values were established for both upper extremities and for average bilateral performance. Males demonstrated significantly greater reach distances than females; however, the difference decreased after normalization for limb length. Age-related variations were observed, with participants aged 26-30 years achieving the highest normalized reach scores (p < 0.05). CONCLUSION: The age- and sex-specific normative values obtained from this study can serve as benchmarks for assessing shoulder mobility and stability among healthy Indian adults aged 18-36 years. CI - Copyright: (c) 2025 Pavithran et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Pavithran, Arjun AU - Pavithran A AD - Institute of Physiotherapy, Srinivas University, City Campus, Mangaluru, India. FAU - Rajasekar, S AU - Rajasekar S AD - Institute of Physiotherapy, Srinivas University, City Campus, Mangaluru, India. AD - College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates. FAU - Cleland, Joshua AU - Cleland J AD - Department of Rehabilitation Sciences, Doctor of Physical Therapy, Program, Tufts University School of Medicine, Boston, United States of America. FAU - Ramkumar, Varunkumar AU - Ramkumar V AD - Department of Physical Medicine and Rehabilitation, Madurai Medical College, Madurai, India. FAU - Hazari, Animesh AU - Hazari A AUID- ORCID: 0000-0002-3936-5029 AD - College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates. LA - eng PT - Journal Article DEP - 20251027 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Adolescent MH - India MH - Young Adult MH - Cross-Sectional Studies MH - *Upper Extremity/physiology MH - *Postural Balance/physiology MH - Reference Values MH - Healthy Volunteers PMC - PMC12558448 COIS- The authors have declared that no competing interests exist. EDAT- 2025/10/27 18:26 MHDA- 2025/10/27 18:27 PMCR- 2025/10/27 CRDT- 2025/10/27 13:33 PHST- 2025/07/11 00:00 [received] PHST- 2025/10/10 00:00 [accepted] PHST- 2025/10/27 18:27 [medline] PHST- 2025/10/27 18:26 [pubmed] PHST- 2025/10/27 13:33 [entrez] PHST- 2025/10/27 00:00 [pmc-release] AID - PONE-D-25-37712 [pii] AID - 10.1371/journal.pone.0335443 [doi] PST - epublish SO - PLoS One. 2025 Oct 27;20(10):e0335443. doi: 10.1371/journal.pone.0335443. eCollection 2025. PMID- 41143870 OWN - NLM STAT- MEDLINE DCOM- 20260225 LR - 20260507 IS - 1541-3144 (Electronic) IS - 0194-2638 (Linking) VI - 46 IP - 2 DP - 2026 TI - Test-Retest Reliability and Concurrent Validity of the One-Minute Sit to Stand Test in Children and Adolescents Who are Overweight or Obese. PG - 306-320 LID - 10.1080/01942638.2025.2576746 [doi] AB - AIMS: To assess test-retest reliability and concurrent validity of the 1-min sit-to-stand test (1-minSTST) in children and adolescents who are overweight or obese. METHODS: Thirty-nine overweight and obese children and adolescents were included. The 1-minSTST was administered twice with a one-hour break. Concurrent validity was evaluated by assessing correlations between 1-minSTST repetitions and six-minute walk test (6MWT) distances. The cardiorespiratory measures (blood pressure, heart rate, oxygen saturation, respiratory rate, dyspnea, and perceived fatigue) were recorded before and after each test. RESULTS: Test-retest reliability was excellent (ICC: 0.90, 95% confidence interval 0.90-0.97). There was no relationship between scores on the 1-minSTST and 6MWT (r = -0.06, p = 0.71). No statistically significant correlation was found between scores on each test and change in cardiorespiratory responses, except for respiratory rate (r = 0.43, p = 0.006). Change in cardiorespiratory responses was similar when performing each test (p > 0.05). CONCLUSION: While the 1-minSTST seems promising, it is not significantly related to the 6MWT, indicating they may assess different dimensions of fitness in this population. Further investigations are needed to determine the clinical implications of 1-minSTST outcomes in pediatric population. FAU - Benkhalifa, Nesrine AU - Benkhalifa N AUID- ORCID: 0000-0002-2265-9047 AD - Institute of Graduate Studies, Department of Physiotherapy and Rehabilitation, Istanbul University-Cerrahpasa, Istanbul, Turkiye. FAU - Emirza Cilbir, Cigdem AU - Emirza Cilbir C AUID- ORCID: 0000-0002-9817-1021 AD - Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Istanbul Kultur University, Istanbul, Turkiye. FAU - Ercan, Oya AU - Ercan O AUID- ORCID: 0000-0001-7397-2837 AD - Cerrahpasa Medical Faculty, Divisions of Pediatric Endocrinology and Adolescent Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkiye. FAU - Kuran Aslan, Goksen AU - Kuran Aslan G AUID- ORCID: 0000-0002-0169-0707 AD - Faculty of Health Sciences, Division of Physiotherapy and Rehabilitation, Istanbul University-Cerrahpasa, Istanbul, Turkiye. LA - eng PT - Journal Article PT - Validation Study DEP - 20251027 PL - England TA - Phys Occup Ther Pediatr JT - Physical & occupational therapy in pediatrics JID - 8109120 SB - IM MH - Humans MH - Child MH - Adolescent MH - Male MH - Female MH - Reproducibility of Results MH - *Exercise Test/methods MH - *Pediatric Obesity/physiopathology MH - Heart Rate MH - *Overweight/physiopathology MH - Respiratory Rate MH - Walk Test MH - Cardiorespiratory Fitness MH - Blood Pressure OTO - NOTNLM OT - 1-minute sit-to-stand test OT - Adolescent obesity OT - cardiorespiratory responses OT - childhood obesity OT - functional capacity OT - overweight OT - reliability OT - validity EDAT- 2025/10/27 13:29 MHDA- 2026/02/25 10:20 CRDT- 2025/10/27 11:54 PHST- 2026/02/25 10:20 [medline] PHST- 2025/10/27 13:29 [pubmed] PHST- 2025/10/27 11:54 [entrez] AID - 10.1080/01942638.2025.2576746 [doi] PST - ppublish SO - Phys Occup Ther Pediatr. 2026;46(2):306-320. doi: 10.1080/01942638.2025.2576746. Epub 2025 Oct 27. PMID- 41143467 OWN - NLM STAT- MEDLINE DCOM- 20251027 LR - 20251102 IS - 1745-5065 (Electronic) IS - 1745-5057 (Print) IS - 1745-5057 (Linking) VI - 21 DP - 2025 Jan-Dec TI - Assessment of maternal nutritional status in early pregnancy and gestational weight gain in selected areas in the Philippines: A pilot study. PG - 17455057251379225 LID - 10.1177/17455057251379225 [doi] LID - 17455057251379225 AB - BACKGROUND: Information on pre-pregnancy body mass index (BMI), gestational weight gain (GWG), and adverse outcomes in the Philippines is limited particularly in primary care settings. OBJECTIVES: This study aims to assess the nutritional status of Filipino women in early pregnancy, their GWG, and associated outcomes. DESIGN: This prospective study included 176 Filipino pregnant women aged 15-49 years, recruited from 35 locations between October 2021 and December 2022. METHODS: Measured weight was recorded in the mother-infant booklet by midwives as reported by pregnant women through phone interviews. Weight during the first prenatal visit (<15 completed weeks) was considered the pre-pregnancy weight (PPW). Pre-pregnancy BMI was calculated using the World Health Organization and Centers for Disease Control and Prevention classifications. Total GWG (tGWG) was determined by subtracting PPW from the weight measured at the last prenatal visit, assessed according to the 2009 Institute of Medicine (IOM) recommendations, and analyzed using logistic regression. Dietary intake was assessed using the standardized 24-h food recall method. RESULTS: Of the study participants, 15.3% were underweight, 56.8% normal, and 27.8% overweight/obese. The mean tGWG was 9.0 +/- 4.9 kg, with most women having a tGWG below the 2009 IOM recommendations. Overweight and obese women had nearly three times the odds of having a cesarean section (odds ratio [OR] 2.85 (95% confidence interval [CI] 1.14-7.13), p = 0.025), while those whose gestational weight gain was below the IOM recommendations had significantly lower odds of having such a procedure (OR 0.24 (95% CI 0.09-0.67), p = 0.007). CONCLUSION: Total GWG varies by pre-pregnancy BMI, with many Filipino women not meeting the 2009 IOM recommendations for GWG, yet without negative outcomes. These findings indicate that lower GWG may be typical among Filipino women. From the outcomes studied, only the rate of cesarean sections and having a GWG below the 2009 IOM recommendations reached statistical significance. This highlights the need for further evaluation of the 2009 IOM recommendations for Filipino women through well-designed prospective studies. FAU - Frane, Ruby D AU - Frane RD AUID- ORCID: 0009-0000-7276-3654 AD - Department of Science and Technology, Food and Nutrition Research Institute, Taguig City, Philippines. FAU - Duante, Charmaine A AU - Duante CA AUID- ORCID: 0009-0007-9769-2283 AD - Department of Science and Technology, Food and Nutrition Research Institute, Taguig City, Philippines. FAU - Goyena, Eva A AU - Goyena EA AUID- ORCID: 0000-0002-2282-5965 AD - Department of Science and Technology, Food and Nutrition Research Institute, Taguig City, Philippines. FAU - Santos, Marvin C Delos AU - Santos MCD AD - Department of Science and Technology, Food and Nutrition Research Institute, Taguig City, Philippines. FAU - Lat, Hazel T AU - Lat HT AUID- ORCID: 0009-0008-5382-4165 AD - Department of Nutrition and Dietetics, Institute of Health Sciences and Nursing, Far Eastern University, Manila, Philippines. FAU - Mendoza, David Kenneth C AU - Mendoza DKC AUID- ORCID: 0009-0004-3463-7605 AD - Department of Science and Technology, Food and Nutrition Research Institute, Taguig City, Philippines. FAU - Labrador, Jason Paolo H AU - Labrador JPH AUID- ORCID: 0000-0002-9811-4748 AD - Department of Science and Technology, Food and Nutrition Research Institute, Taguig City, Philippines. FAU - Tajan, Merlyn G AU - Tajan MG AD - Department of Science and Technology, Food and Nutrition Research Institute, Taguig City, Philippines. FAU - Benavidez-Fabi, Kristine Marie N AU - Benavidez-Fabi KMN AUID- ORCID: 0009-0007-9762-9284 AD - Department of Science and Technology, Food and Nutrition Research Institute, Taguig City, Philippines. FAU - Padolina, Christia S AU - Padolina CS AD - Philippine Obstetrical and Gynecological Society Foundation, Inc., Quezon City, Philippines. LA - eng PT - Journal Article DEP - 20251027 PL - United States TA - Womens Health (Lond) JT - Women's health (London, England) JID - 101271249 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Philippines/epidemiology MH - Adult MH - *Gestational Weight Gain MH - Pilot Projects MH - *Nutritional Status MH - Prospective Studies MH - Body Mass Index MH - Adolescent MH - Young Adult MH - Middle Aged MH - Prenatal Care MH - *Maternal Nutritional Physiological Phenomena MH - Pregnancy Complications/epidemiology PMC - PMC12575983 OAB - A pilot study exploring the relation of maternal nutritional status and gestational weight gain to adverse pregnancy outcomes among Filipino women in primary care settingsWhy was the study done?Maternal nutritional status and gestational weight gain (GWG) are linked to negative pregnancy and birth outcomes. However, this information about the Filipino female population is understudied in the Philippines. The study aimed to examine these associations.What did the researchers do?The team conducted phone interviews with pregnant women nationwide, using a structured questionnaire to gather socio-demographic, obstetric, and other relevant information including maternal and fetal outcomes. Midwives measured the maternal weight and height during antenatal check-ups, and participating women provided screenshots of these measurements for verification after each interview.What did the researchers find?Among the participants, 15.3% were underweight, 56.8% were normal weight, and 27.8% were overweight or obese. Most women had GWG below the 2009 IOM recommendations, with no negative effects observed, except that overweight and obese women were nearly three times more likely to have cesarean sections than those whose GWG was below the aforementioned recommendations.What do the findings mean?The study highlights that GWG varies by pre-pregnancy BMI, with underweight women gaining the most weight. Lower GWG is common among Filipino women. The impact of being overweight or obese on maternal outcomes is significant and cannot be overlooked. Given the limited sample size, this underscores the need for a thorough evaluation of the applicability of IOM recommendations specifically for Filipino women. Therefore, well-designed future research is essential to validate and strengthen the conclusions drawn from this study. OABL- eng OTO - NOTNLM OT - early pregnancy OT - gestational weight gain OT - low birth weight OT - maternal and birth outcomes OT - maternal nutritional status COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/10/27 15:16 MHDA- 2025/10/27 15:17 PMCR- 2025/10/27 CRDT- 2025/10/27 08:23 PHST- 2025/10/27 15:17 [medline] PHST- 2025/10/27 15:16 [pubmed] PHST- 2025/10/27 08:23 [entrez] PHST- 2025/10/27 00:00 [pmc-release] AID - 10.1177_17455057251379225 [pii] AID - 10.1177/17455057251379225 [doi] PST - ppublish SO - Womens Health (Lond). 2025 Jan-Dec;21:17455057251379225. doi: 10.1177/17455057251379225. Epub 2025 Oct 27. PMID- 41142950 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251027 LR - 20251029 IS - 2472-1751 (Electronic) IS - 2472-1751 (Linking) VI - 9 IP - 3 DP - 2025 TI - Dynamic fluctuations of intrinsic brain activity are associated with consistent topological patterns in puberty and are biomarkers of neural maturation. PG - 1039-1064 LID - 10.1162/netn_a_00452 [doi] AB - Intrinsic brain dynamics play a fundamental role in cognitive function, but their development is incompletely understood. We investigated pubertal changes in temporal fluctuations of intrinsic network topologies (focusing on the strongest connections and coordination patterns) and signals, in an early longitudinal sample from the Adolescent Brain Cognitive Development (ABCD) study, with resting-state fMRI (n = 4,099 at baseline; n = 3,376 at follow-up [median age = 10.0 (1.1) and 12.0 (1.1) years; n = 2,116 with both assessments]). Reproducible, inverse associations between low-frequency signal and topological fluctuations were estimated (p < 0.05, beta = -0.20 to -0.02, 95% confidence interval (CI) = [-0.23, -0.001]). Signal (but not topological) fluctuations increased in somatomotor and prefrontal areas with pubertal stage (p < 0.03, beta = 0.06-0.07, 95% CI = [0.03, 0.11]), but decreased in orbitofrontal, insular, and cingulate cortices, as well as cerebellum, hippocampus, amygdala, and thalamus (p < 0.05, beta = -0.09 to -0.03, 95% CI = [-0.15, -0.001]). Higher temporal signal and topological variability in spatially distributed regions were estimated in girls. In racial/ethnic minorities, several associations between signal and topological fluctuations were in the opposite direction of those in the entire sample, suggesting potential racial differences. Our findings indicate that during puberty, intrinsic signal dynamics change significantly in developed and developing brain regions, but their strongest coordination patterns may already be sufficiently developed and remain temporally consistent. CI - (c) 2025 Massachusetts Institute of Technology. FAU - Lim, Jethro AU - Lim J AD - Department of Pediatrics, Division of Adolescent and Young Adult Medicine, Boston Children's Hospital, Boston, MA, USA. FAU - Cooper, Kaitlynn AU - Cooper K AD - Department of Pediatrics, Division of Adolescent and Young Adult Medicine, Boston Children's Hospital, Boston, MA, USA. AD - Carnegie Mellon University, Pittsburgh, PA, USA. FAU - Stamoulis, Catherine AU - Stamoulis C AD - Department of Pediatrics, Division of Adolescent and Young Adult Medicine, Boston Children's Hospital, Boston, MA, USA. AD - Department of Pediatrics, Harvard Medical School, Boston, MA, USA. LA - eng PT - Journal Article DEP - 20250919 PL - United States TA - Netw Neurosci JT - Network neuroscience (Cambridge, Mass.) JID - 101719149 PMC - PMC12548668 OAB - We have investigated pubertal changes in intrinsic signal and network dynamics, estimated from resting-state fMRI in a sample of youth from the ABCD study. We have identified reproducible, inverse associations between low-frequency signal and topological fluctuations, as well as pubertal changes in intrinsic signal dynamics but not topological patterns of strongly connected networks. We have also identified sex differences in these dynamics and negative associations with body mass index (BMI). Several associations between signal and topological fluctuations were in the opposite direction in racial/ethnic minorities compared with those in the entire sample. Our findings indicate that intrinsic signal dynamics change significantly in developed and developing brain regions during puberty, but their strongest synchronization patterns may already be sufficiently developed prior to puberty and are dynamically reproducible. OABL- eng OTO - NOTNLM OT - Connectome OT - Developing brain OT - Fluctuation amplitude OT - Intrinsic dynamics OT - Resting-state topology COIS- Competing Interests: The authors have declared that no competing interests exist. EDAT- 2025/10/27 15:16 MHDA- 2025/10/27 15:17 PMCR- 2025/09/19 CRDT- 2025/10/27 07:25 PHST- 2024/07/24 00:00 [received] PHST- 2025/02/24 00:00 [accepted] PHST- 2025/10/27 15:17 [medline] PHST- 2025/10/27 15:16 [pubmed] PHST- 2025/10/27 07:25 [entrez] PHST- 2025/09/19 00:00 [pmc-release] AID - netn_a_00452 [pii] AID - 10.1162/netn_a_00452 [doi] PST - epublish SO - Netw Neurosci. 2025 Sep 19;9(3):1039-1064. doi: 10.1162/netn_a_00452. eCollection 2025. PMID- 41139714 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261010 IS - 1745-1701 (Electronic) IS - 0586-7614 (Print) IS - 0586-7614 (Linking) VI - 52 IP - 5 DP - 2026 Aug 20 TI - Testing the Transportability of the Psychosis Metabolic Risk Calculator in Canada (Quebec): International External Validation Study. LID - 10.1093/schbul/sbaf174 [doi] LID - sbaf174 AB - BACKGROUND AND HYPOTHESIS: Cardiometabolic morbidity largely explains premature mortality in people with psychotic disorders and is detectable from psychosis onset. Currently, no accurate cardiometabolic risk prediction tool exists for young people with first-episode psychosis (FEP). The Psychosis Metabolic Risk Calculator (PsyMetRiC) aims to bridge this gap, but its accuracy and potential clinical usefulness in North American populations remain unverified. STUDY DESIGN: The external validity of PsyMetRiC, developed in the United Kingdom to predict the risk of incident metabolic syndrome (MetS) up to 6 years after a FEP, was assessed using the data from the Quebec Psychosis Early Intervention Clinic. PsyMetRiC comprises 2 penalized logistic regression models: a full-model including age, sex, ethnicity, body mass index (BMI), smoking status, prescription of metabolically-active antipsychotic medication, high-density lipoprotein (HDL), and triglyceride concentrations; and a partial-model excluding biochemical predictors. Patients aged 16-35 years, diagnosed with FEP between 2004 and 2023 without pre-existing MetS, and with>12 months follow-up were included. Predictive performance of PsyMetRiC was assessed by discrimination (C-statistic), calibration (calibration plots), and clinical usefulness (decision curve analysis). The race and ethnicity predictor was refined to better represent the North American population. STUDY RESULTS: Among 559 included patients (mean age 24.1 years +/-4.1; 22.5% female), 18.2% developed MetS during a mean follow-up of 1.7 +/- 1.3 years. Compared with the UK development cohort, the Canadian sample exhibited a higher BMI, lower HDL cholesterol, lower triglycerides, lower blood glucose, and lower systolic blood pressure. Discrimination performance was acceptable (full model C = 0.74, 95% CI, 0.70-0.77; intercept = 0.225; slope = 1.278; partial model C = 0.70, 95% CI, 0.67-0.74; intercept = -0.555; slope = 0.993). After updating the model with a race and ethnicity predictor calibrated to locally representative categories, performance improved slightly (full model C = 0.74, 95% CI, 0.71-0.77; intercept = 0.000; slope = 1.001; partial model C = 0.71, 95% CI, 0.68-0.74; intercept = 0.001; slope = 1.005). CONCLUSIONS: This study provides the first external validation of PsyMetRiC in a North American sample. Further research is essential before routine clinical implementation, but PsyMetRiC offers promise as a tool for early detection of cardiometabolic risk in early psychosis, guiding personalized treatments to diminish long-term physical health impacts. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. FAU - Brodeur, Sebastien AU - Brodeur S AD - Department of Psychiatry and Neuroscience, Faculty of Medicine, Laval University, Quebec, G1V 0A6, Canada. AD - CERVO Brain Research Centre, Quebec, G1E 1T2, Canada. AD - Early Psychosis: Interventions and Clinical-Detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, United Kingdom. AD - University Institute in Mental Health of Quebec, Quebec, G1J 2G3, Canada. FAU - Corbeil, Olivier AU - Corbeil O AUID- ORCID: 0000-0002-4192-853X AD - CERVO Brain Research Centre, Quebec, G1E 1T2, Canada. AD - University Institute in Mental Health of Quebec, Quebec, G1J 2G3, Canada. AD - Faculty of Pharmacy, Laval University, Quebec, G1V 0A6, Canada. FAU - Bechard, Laurent AU - Bechard L AUID- ORCID: 0000-0001-6697-1799 AD - CERVO Brain Research Centre, Quebec, G1E 1T2, Canada. AD - University Institute in Mental Health of Quebec, Quebec, G1J 2G3, Canada. AD - Faculty of Pharmacy, Laval University, Quebec, G1V 0A6, Canada. FAU - Huot-Lavoie, Maxime AU - Huot-Lavoie M AUID- ORCID: 0000-0001-7378-9776 AD - CERVO Brain Research Centre, Quebec, G1E 1T2, Canada. AD - University Institute in Mental Health of Quebec, Quebec, G1J 2G3, Canada. FAU - Desmeules, Charles AU - Desmeules C AD - CERVO Brain Research Centre, Quebec, G1E 1T2, Canada. AD - University Institute in Mental Health of Quebec, Quebec, G1J 2G3, Canada. FAU - Oliver, Dominic AU - Oliver D AUID- ORCID: 0000-0002-8920-3407 AD - Early Psychosis: Interventions and Clinical-Detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, United Kingdom. AD - Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, United Kingdom. AD - NIHR Oxford Health Biomedical Research Centre, Oxford, OX3 7JX, United Kingdom. AD - OPEN Early Detection Service, Oxford Health NHS Foundation Trust, Oxford, OX3 7JH, United Kingdom. FAU - De Micheli, Andrea AU - De Micheli A AD - Early Psychosis: Interventions and Clinical-Detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, United Kingdom. AD - OASIS Service, South London and Maudsley NHS Foundation Trust, SE11 5DL, United Kingdom. FAU - Osimo, Emanuele F AU - Osimo EF AUID- ORCID: 0000-0001-6239-5691 AD - Department of Psychiatry, University of Cambridge, Cambridge, CB20SZ, United Kingdom. AD - Cambridgeshire and Peterborough NHS Foundation Trust, CB21 5EF, United Kingdom. FAU - Upthegrove, Rachel AU - Upthegrove R AD - Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, United Kingdom. AD - Institute for Mental Health, University of Birmingham, Birmingham, B15 2TT, United Kingdom. FAU - Khandaker, Golam M AU - Khandaker GM AD - Bristol Medical School, University of Bristol, Bristol, BS8 1UD, United Kingdom. FAU - Murray, Graham K AU - Murray GK AUID- ORCID: 0000-0001-8296-1742 AD - Department of Psychiatry, University of Cambridge, Cambridge, CB20SZ, United Kingdom. AD - Cambridgeshire and Peterborough NHS Foundation Trust, CB21 5EF, United Kingdom. FAU - Lajeunesse-Trempe, Fanny AU - Lajeunesse-Trempe F AD - Quebec Heart and Lung University Institute, Laval University, Quebec, G1V 4G5, Canada. FAU - Cheung, Gloria AU - Cheung G AD - Hull York Medical School, York, YO10 5DD, United Kingdom. AD - York and Scarborough Teaching Hospitals NHS Foundation Trust, York, YO31 8HE, United Kingdom. FAU - Courteau, Josiane AU - Courteau J AD - PRIMUS Research Group, Research Centre of the Sherbrooke University Hospital, Sherbrooke, J1H 5H3, Canada. FAU - Theriault, Chantale AU - Theriault C AD - CERVO Brain Research Centre, Quebec, G1E 1T2, Canada. AD - University Institute in Mental Health of Quebec, Quebec, G1J 2G3, Canada. FAU - Roy, Marc-Andre AU - Roy MA AD - CERVO Brain Research Centre, Quebec, G1E 1T2, Canada. AD - University Institute in Mental Health of Quebec, Quebec, G1J 2G3, Canada. AD - Faculty of Pharmacy, Laval University, Quebec, G1V 0A6, Canada. FAU - Demers, Marie-France AU - Demers MF AD - CERVO Brain Research Centre, Quebec, G1E 1T2, Canada. AD - University Institute in Mental Health of Quebec, Quebec, G1J 2G3, Canada. AD - Faculty of Pharmacy, Laval University, Quebec, G1V 0A6, Canada. FAU - Perry, Benjamin I AU - Perry BI AD - Institute for Mental Health, University of Birmingham, Birmingham, B15 2TT, United Kingdom. LA - eng GR - RAPPSODIS Lab: Recherche Axee sur la Personne et la Psychose/ PT - Journal Article PT - Validation Study PL - United States TA - Schizophr Bull JT - Schizophrenia bulletin JID - 0236760 SB - IM MH - Humans MH - *Psychotic Disorders/epidemiology/metabolism MH - Female MH - *Metabolic Syndrome/epidemiology/diagnosis MH - Adolescent MH - Adult MH - Quebec/epidemiology MH - Young Adult MH - Male MH - Risk Assessment/standards/methods MH - *Cardiometabolic Risk Factors PMC - PMC13645815 OTO - NOTNLM OT - First-episode psychosis (FEP) OT - Metabolic syndrome (MetS) OT - North-America OT - external validation OT - risk prediction model COIS- O.C. is supported by a Canadian Institutes of Health Research fellowship award. L.B. has received a grant by Fonds de recherche du Quebec-Sante (FRQS) in partnership with the Unite de Soutien SSA du Quebec. M.-A. R. reports grants from Mylan Canada, Janssen Canada, Mylan Canada and Otsuka- Lundbeck Alliance Canada during the conduct of the study. M.-F.D. reports grants from Mylan Canada, Janssen Canada, and Otsuka Lundbeck outside the submitted work. All other authors declare no competing interests. EDAT- 2025/10/27 13:28 MHDA- 2026/10/08 05:31 PMCR- 2025/10/27 CRDT- 2025/10/27 00:14 PHST- 2024/12/19 00:00 [received] PHST- 2025/06/03 00:00 [revised] PHST- 2025/09/16 00:00 [accepted] PHST- 2026/10/08 05:31 [medline] PHST- 2025/10/27 13:28 [pubmed] PHST- 2025/10/27 00:14 [entrez] PHST- 2025/10/27 00:00 [pmc-release] AID - 8303407 [pii] AID - sbaf174 [pii] AID - 10.1093/schbul/sbaf174 [doi] PST - ppublish SO - Schizophr Bull. 2026 Aug 20;52(5):sbaf174. doi: 10.1093/schbul/sbaf174. PMID- 41139316 OWN - NLM STAT- MEDLINE DCOM- 20260113 LR - 20260113 IS - 1466-447X (Electronic) IS - 0264-0414 (Linking) VI - 44 IP - 3 DP - 2026 Feb TI - Reliability of radar-derived measures of sprint performance in female field sport athletes. PG - 322-334 LID - 10.1080/02640414.2025.2578579 [doi] AB - Radar is commonly used to assess overground sprinting performance and estimate the force-velocity-power (FvP) mechanical variables; however, limited work has examined the reliability of these measures in female field sport athletes. This study aimed to assess the reliability of radar-derived measures, and to examine the associations between sprinting split times and the FvP. Twenty-three female rugby league and field hockey athletes (15-35 yrs, 70.2 +/- 12.2 kg, 169 +/- 6 cm) completed two 40 m sprints on two separate days. Split times displayed acceptable inter-day absolute reliability (CV = 0.91-2.17%) as did the FvP (CV range = 1.37-6.28%), however, relative reliability ranged from moderate to excellent (ICC(3,1) = 0.60-0.98) or poor to excellent (ICC(3,1) = 0.15-0.96), respectively. Maximal power output (P(MAX) W/kg) was most associated to 0-30 m (r = -0.95). However, for completion time of the maximal velocity phase (CT(MVP)) (20-40 m), P(MAX) (W/kg) displayed a moderate association (r = -0.69), in comparison, power output at maximal velocity (P(VMAX) W/kg) displayed a stronger association (r = -0.83). Utilising the fastest trial on a given day is suitable for monitoring sprinting performance, whilst correlations between split-times and the FvP in the current study provide important insights into the sprinting mechanics of female field sport athletes. FAU - Martin, Andrew AU - Martin A AUID- ORCID: 0000-0001-9275-2581 AD - School of Health Sciences and Social Work, Griffith University, Gold Coast, Australia. AD - Griffith Sports Science, Griffith University, Gold Coast, Australia. FAU - Bourne, Matthew AU - Bourne M AD - School of Health Sciences and Social Work, Griffith University, Gold Coast, Australia. FAU - Minahan, Clare AU - Minahan C AD - Griffith Sports Science, Griffith University, Gold Coast, Australia. FAU - Duhig, Steven AU - Duhig S AD - School of Health Sciences and Social Work, Griffith University, Gold Coast, Australia. FAU - Bellinger, Phillip AU - Bellinger P AD - Griffith Sports Science, Griffith University, Gold Coast, Australia. LA - eng PT - Journal Article DEP - 20251026 PL - England TA - J Sports Sci JT - Journal of sports sciences JID - 8405364 SB - IM MH - Humans MH - Female MH - *Athletic Performance/physiology MH - *Running/physiology MH - Young Adult MH - Adult MH - Reproducibility of Results MH - Adolescent MH - Hockey/physiology MH - *Radar MH - Football/physiology MH - Biomechanical Phenomena OTO - NOTNLM OT - Female sprinting OT - force-velocity-power OT - inverse dynamics OT - radar OT - sprinting phases EDAT- 2025/10/27 13:27 MHDA- 2026/01/13 13:16 CRDT- 2025/10/26 10:33 PHST- 2026/01/13 13:16 [medline] PHST- 2025/10/27 13:27 [pubmed] PHST- 2025/10/26 10:33 [entrez] AID - 10.1080/02640414.2025.2578579 [doi] PST - ppublish SO - J Sports Sci. 2026 Feb;44(3):322-334. doi: 10.1080/02640414.2025.2578579. Epub 2025 Oct 26. PMID- 41137244 OWN - NLM STAT- MEDLINE DCOM- 20251025 LR - 20251203 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 104 IP - 43 DP - 2025 Oct 24 TI - Weight perception and factors associated with misperception among university students in Turkey: A descriptive survey. PG - e45514 LID - 10.1097/MD.0000000000045514 [doi] LID - e45514 AB - Weight misperception (WM) is common and associated with adverse health outcomes. Moreover, it may be associated with anti-obesity medication misuse. Previous studies in other countries report that WM is common among university students. However, its frequency differs between countries, and data regarding university students in Turkey are lacking. We designed and conducted a descriptive survey on a university campus in Turkey. Demographic, anthropometric, educational, nutritional, and perceptional data were acquired. WM was analyzed by a verbal scale and a previously developed and validated body size guide scale. Appropriate perception (AP) was defined as "being in the body mass index group in total concordance with visual or verbal weight perception question's answers" Misperceptions were grouped as weight overestimation and underestimation. Factors associated with misperceptions were analyzed using multivariate multinomial logistic regression analysis. 748 participants were included in the analysis. Median age was 21 (2), and 437 (58.4%) participants were female. Verbal and visually APs were 75% and 65%, respectively. Female participants had significantly higher AP rates in both verbal and visual scales (79.6% vs 67.5%, and 70% vs 58.8%; P < .001 and P = .001, respectively). Among participants with misperception, the females had significantly higher overestimation rates (12.8% vs 2.6%, P < .001), while the males had significantly higher underestimation rates (7.6% vs 29.6%, P = .001). Logistic regression analysis demonstrated that body-mass index, gender, tobacco use, overall health perception, physical self-esteem, and fast-food serving were associated with misperception in different models. This study demonstrated that WM is common among university students in Turkey, and the major predictors are gender and body-mass index. However, these variables have opposite effects in different WM types. While being a lean female is associated with weight overestimation, being an overweight male is associated with weight underestimation. Previous studies illustrate both parallel and conflicting results, which may be explained by different ages and cultural aspects of the study that has been undertaken. Further research with larger and more diverse populations may elucidate this controversy. CI - Copyright (c) 2025 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Guven, Alper Tuna AU - Guven AT AUID- ORCID: 0000-0002-6310-4240 AD - Division of General Internal Medicine, Department of Internal Medicine, Faculty of Medicine, Baskent University, Ankara, Turkey. FAU - Yildiz Comert, Kubra AU - Yildiz Comert K AUID- ORCID: 0000-0002-0105-2027 AD - Department of Internal Medicine, Faculty of Medicine, Baskent University, Ankara, Turkey. FAU - Inan, Mehmet Meric AU - Inan MM AUID- ORCID: 0009-0003-3034-8622 AD - Faculty of Medicine, Baskent University, Ankara, Turkey. FAU - Yigit, Selma AU - Yigit S AUID- ORCID: 0009-0003-6604-0777 AD - Faculty of Medicine, Baskent University, Ankara, Turkey. FAU - Binici, Zeynep Sude AU - Binici ZS AUID- ORCID: 0009-0003-1299-2860 AD - Faculty of Medicine, Baskent University, Ankara, Turkey. FAU - Taskin, Deniz AU - Taskin D AUID- ORCID: 0009-0000-0448-3431 AD - Faculty of Medicine, Baskent University, Ankara, Turkey. FAU - Gardiyanoglu, Goktug AU - Gardiyanoglu G AUID- ORCID: 0009-0005-1208-9393 AD - Faculty of Medicine, Baskent University, Ankara, Turkey. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Female MH - Turkey/epidemiology MH - Male MH - *Students/psychology/statistics & numerical data MH - Universities MH - Young Adult MH - Body Mass Index MH - Adult MH - *Body Image/psychology MH - Sex Factors MH - Surveys and Questionnaires MH - Cross-Sectional Studies MH - *Weight Perception MH - Adolescent PMC - PMC12558324 OTO - NOTNLM OT - body image OT - body-mass index OT - obesity OT - weight perception COIS- The authors have no funding and conflicts of interest to disclose. EDAT- 2025/10/25 06:31 MHDA- 2025/10/25 06:32 PMCR- 2025/10/24 CRDT- 2025/10/25 01:01 PHST- 2025/06/30 00:00 [received] PHST- 2025/09/17 00:00 [accepted] PHST- 2025/10/25 06:32 [medline] PHST- 2025/10/25 06:31 [pubmed] PHST- 2025/10/25 01:01 [entrez] PHST- 2025/10/24 00:00 [pmc-release] AID - 00005792-202510240-00031 [pii] AID - MD-D-25-08033 [pii] AID - 10.1097/MD.0000000000045514 [doi] PST - ppublish SO - Medicine (Baltimore). 2025 Oct 24;104(43):e45514. doi: 10.1097/MD.0000000000045514. PMID- 41137116 OWN - NLM STAT- MEDLINE DCOM- 20251025 LR - 20251027 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 13 IP - 1 DP - 2025 Oct 24 TI - Meat-eating justifications in Turkiye: cultural adaptation, validation, and correlates of the MEJ and 4Ns scales. PG - 1177 LID - 10.1186/s40359-025-03490-6 [doi] LID - 1177 AB - BACKGROUND: People often avoid and try to stay ignorant of the negative aspects of meat production and consumption. When asked, people justify their meat consumption by emphasizing the necessity of meat for health, its desirable taste, naturalness, and normality. Relevant measures were developed to measure how much individuals rely on meat-eating justifications. Thus, the current work aims to translate and adapt the 4Ns scale by Piazza et al. (Appetite 91:114-128, 2015) and the Meat-eating Justifications Scale (MEJ) by Rothgerber (Psychol Men Masc 14(4):363-375, 2013) to Turkish to enable theoretical and applied studies of meat-eating in Turkish. METHODS: The relevant measures are translated and adapted to Turkish by expanding the item pool. The data of the translated measures and other relevant variables is collected between May 22 and December 31, 2022 (N = 520). The sample is divided into two parts: the first subsample is used to conduct Exploratory Factor Analysis (EFA), and the other is used to conduct Confirmatory Factor Analysis (CFA). Finally, a correlation matrix is created with the finalized versions of the meat-eating justification measures and other variables of interest. RESULTS: EFA for the 4Ns revealed a four-factor solution aligning with the original theoretical framework. Since the original measure accepted a single-factor solution, the current work improved on the original by reworking the low-loading items and introducing culture-specific items. After decisions about certain items, CFA is conducted, which indicated good fit (chi(2)(98) = 193.4, p < .05, CFI = .96, RMSEA = .061, [CI = .048, .074]), internal consistency reliability (Cronbach's alpha = .95, McDonald's omega_total = .95) and test-retest reliability (.92). EFA for MEJ indicated an eight-factor solution, where a subscale was discarded. CFA showed good fit (chi2(224) = 435.9, p < .05, CFI = .945, RMSEA = .06, [CI = .052, .069]), internal consistency reliability (Cronbach's alpha = .89, McDonald's omega_total = .91) and test-retest reliability (.89). CONCLUSION: Cross-cultural adaptation and validation of the meat-eating justification scales enable a better theoretical understanding of the psychology of meat-eating. This is demonstrated by replicating the strong associations between meat-eating, its justifications, social dominance orientation, speciesism, and masculinity in a different cultural context. This understanding is essential for prevention and intervention efforts to reduce meat consumption. CI - (c) 2025. The Author(s). FAU - Sayat, Rusen Ali AU - Sayat RA AUID- ORCID: 0000-0003-2271-9879 AD - Department of Psychology, Middle East Technical University, Ankara, Turkiye. rusen.sayat@metu.edu.tr. FAU - Bozo, Ozlem AU - Bozo O AUID- ORCID: 0000-0002-4480-1876 AD - Department of Psychology, Middle East Technical University, Ankara, Turkiye. LA - eng PT - Journal Article PT - Validation Study DEP - 20251024 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Male MH - Turkey MH - Adult MH - Female MH - *Meat MH - *Psychometrics/instrumentation MH - Young Adult MH - Reproducibility of Results MH - Middle Aged MH - Surveys and Questionnaires/standards MH - *Feeding Behavior/psychology MH - Factor Analysis, Statistical MH - *Food Preferences/psychology MH - Adolescent PMC - PMC12553248 OTO - NOTNLM OT - Meat-eating justifications OT - Meat-related cognitive dissonance OT - Social dominance orientation OT - Speciesism COIS- Declarations. Ethics approval and consent to participate: This research was conducted in accordance with the American Psychological Association (APA) Ethical Guidelines. Before the data collection, an institutional review board approval was obtained from the Human Subjects Ethics Committee of the Middle East Technical University (231-ODTUIAEK-2022). All participants agreed to the informed consent form that included all of the information regarding the study and its aims. Consent for publication: In the informed consent form, all participants were informed that they were free to leave the study any time they wished, and they agreed that their data could be analyzed and published for scientific purposes. Competing interests: The authors declare no competing interests. EDAT- 2025/10/25 00:30 MHDA- 2025/10/25 06:29 PMCR- 2025/10/24 CRDT- 2025/10/24 23:57 PHST- 2024/07/05 00:00 [received] PHST- 2025/09/19 00:00 [accepted] PHST- 2025/10/25 06:29 [medline] PHST- 2025/10/25 00:30 [pubmed] PHST- 2025/10/24 23:57 [entrez] PHST- 2025/10/24 00:00 [pmc-release] AID - 10.1186/s40359-025-03490-6 [pii] AID - 3490 [pii] AID - 10.1186/s40359-025-03490-6 [doi] PST - epublish SO - BMC Psychol. 2025 Oct 24;13(1):1177. doi: 10.1186/s40359-025-03490-6. PMID- 41136628 OWN - NLM STAT- MEDLINE DCOM- 20251024 LR - 20251027 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Oct 24 TI - Transcriptomic profiling reveals neural-immune-stromal dysregulation and risk-associated gene signatures in advanced keratoconus. PG - 37262 LID - 10.1038/s41598-025-21254-5 [doi] LID - 37262 AB - This study aimed to characterize transcriptomic alterations and the effects of demographic and behavioral risk factors on disease-associated gene expression patterns in late-stage keratoconus (KC). Corneal stromal tissues from 31 KC patients and four normal donors underwent bulk RNA sequencing. Differentially expressed genes (DEGs) and weighted gene co-expression network analysis (WGCNA) were used to identify key molecular changes. Subgroup analyses based on sex, allergy status, eye rubbing intensity (ERI), body mass index (BMI), and childhood socioeconomic status (SES) were conducted using gene set enrichment analysis (GSEA) and WGCNA. Key genes from WGCNA modules were validated by quantitative real-time PCR (qRT-PCR) and three public transcriptomic datasets. Enrichment analyses based on the 4469 identified DEGs (Padj < 0.05) revealed suppression of extracellular matrix (ECM) organization, axon guidance, synaptic signaling, and immune activity (Padj < 0.05). Subgroup GSEA demonstrated that high ERI correlated with ECM pathways, elevated BMI correlated with mitochondrial dysfunction, and low childhood SES correlated with upregulated mitochondrial metabolism and immune activation (Padj < 0.05). Chromatin regulation and antioxidant activity were enriched in females (Padj < 0.05). No transcriptomic associations were detected for allergy status. WGCNA revealed ERI-related modules involving Wnt and PI3K-Akt signaling and SES-related modules implicating cholinergic synapse and axon guidance pathways (Padj < 0.05). Validation using qRT-PCR and public datasets confirmed the downregulation of all 15 selected genes in KC (Padj < 0.05). qRT-PCR also confirmed differential expression of five subgroup-associated genes across KC subgroups (P < 0.05). These findings emphasize the neural-immune-stromal axis dysregulation in KC and elucidate the contribution of common risk factors to disease progression. CI - (c) 2025. The Author(s). FAU - Du, Kaiyue AU - Du K AD - Department of Ophthalmology, Peking University Third Hospital, No.49 Garden North Road, Haidian, Beijing, 100191, China. AD - Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, China. FAU - Peng, Rongmei AU - Peng R AD - Department of Ophthalmology, Peking University Third Hospital, No.49 Garden North Road, Haidian, Beijing, 100191, China. AD - Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, China. FAU - Xiao, Gege AU - Xiao G AD - Department of Ophthalmology, Peking University Third Hospital, No.49 Garden North Road, Haidian, Beijing, 100191, China. AD - Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, China. FAU - Qu, Yi AU - Qu Y AD - Department of Ophthalmology, Peking University Third Hospital, No.49 Garden North Road, Haidian, Beijing, 100191, China. AD - Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, China. FAU - Han, Liang AU - Han L AD - Department of Ophthalmology, Peking University Third Hospital, No.49 Garden North Road, Haidian, Beijing, 100191, China. AD - Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, China. FAU - Hong, Jing AU - Hong J AD - Department of Ophthalmology, Peking University Third Hospital, No.49 Garden North Road, Haidian, Beijing, 100191, China. hongjing196401@163.com. AD - Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, China. hongjing196401@163.com. LA - eng GR - 81970768/National Natural Science Foundation of China/ PT - Journal Article DEP - 20251024 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Keratoconus/genetics/pathology/immunology MH - Female MH - Male MH - *Gene Expression Profiling MH - *Transcriptome MH - Adult MH - Gene Regulatory Networks MH - Risk Factors MH - *Corneal Stroma/metabolism/pathology/immunology MH - Middle Aged PMC - PMC12552476 OTO - NOTNLM OT - Gene regulation OT - Keratoconus OT - Risk factors OT - Transcriptome COIS- Declarations. Ethics approval and consent to participate: Written informed consent was obtained from all patients or the legal guardians of individuals under 18 years and the control donors' next-of-kin for research purposes. The study protocol was approved by the Medical Science Research Ethics Committee of Peking University Third Hospital (Protocol No. M2023859) and adhered strictly to the principles of the Declaration of Helsinki. Consent for publication: Consent for publication was not required as the data are fully anonymized and no identifiable individual information is included. Competing interests: The authors declare no competing interests. EDAT- 2025/10/25 00:30 MHDA- 2025/10/25 00:31 PMCR- 2025/10/24 CRDT- 2025/10/24 23:30 PHST- 2025/07/16 00:00 [received] PHST- 2025/09/19 00:00 [accepted] PHST- 2025/10/25 00:31 [medline] PHST- 2025/10/25 00:30 [pubmed] PHST- 2025/10/24 23:30 [entrez] PHST- 2025/10/24 00:00 [pmc-release] AID - 10.1038/s41598-025-21254-5 [pii] AID - 21254 [pii] AID - 10.1038/s41598-025-21254-5 [doi] PST - epublish SO - Sci Rep. 2025 Oct 24;15(1):37262. doi: 10.1038/s41598-025-21254-5. PMID- 41136627 OWN - NLM STAT- MEDLINE DCOM- 20251024 LR - 20251203 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Oct 24 TI - Psychometric properties of the SMART tool for infant oral feeding skill assessment. PG - 37249 LID - 10.1038/s41598-025-21296-9 [doi] LID - 37249 AB - Premature and medically complex infants are at risk of feeding problems, specifically the delay in the development of independent oral feedings, which leads to prolonged hospital stays, higher costs, malnutrition, developmental delays, and family stress. Available oral feeding skill assessment tools lack strong psychometrics, feasibility, and cost-effectiveness. We developed a novel tool, the SMART tool, to address these barriers. The objective of this study was to establish the psychometric properties of the SMART tool for assessing infant oral feeding skills. The study design was a prospective, observational, multicenter trial. To establish criterion validity, we hypothesized that the performance of the SMART tool would be similar to that of a comparator tool, the Neonatal Eating Outcome Assessment (NEOA) tool. A convenience sample of 76 infants across four level-3 Neonatal Intensive Care Units were enrolled, and 136 complete feeding observations were included. Compared to NEOA, the SMART tool had a sensitivity of 0.76 (95% CI 0.63-0.89) and a specificity of 0.82 (95% CI 0.72-0.93), with a strong correlation (r = 0.7, p < 0.001). Inter-rater reliability of post-feed scores was 100% agreement. The SMART tool is valid, reliable, and feasible for assessing infant oral feeding skills. CI - (c) 2025. The Author(s). FAU - Mishra, Ravi AU - Mishra R AD - Advocate Illinois Masonic Medical Center, Chicago, IL, 60657, USA. ravi.mishra@aah.org. FAU - Albi, Anne AU - Albi A AD - Advocate Illinois Masonic Medical Center, Chicago, IL, 60657, USA. FAU - Lira-Crame, Cynthia AU - Lira-Crame C AD - Advocate Illinois Masonic Medical Center, Chicago, IL, 60657, USA. LA - eng PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20251024 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Psychometrics/methods MH - Female MH - Male MH - Infant MH - Infant, Newborn MH - Prospective Studies MH - Reproducibility of Results MH - *Feeding Behavior MH - Infant, Premature MH - Intensive Care Units, Neonatal PMC - PMC12552714 OTO - NOTNLM OT - Breastfeeding OT - Feeding skills OT - Infant nutrition OT - Psychometric COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/10/25 00:30 MHDA- 2025/10/25 00:31 PMCR- 2025/10/24 CRDT- 2025/10/24 23:30 PHST- 2025/04/20 00:00 [received] PHST- 2025/09/19 00:00 [accepted] PHST- 2025/10/25 00:31 [medline] PHST- 2025/10/25 00:30 [pubmed] PHST- 2025/10/24 23:30 [entrez] PHST- 2025/10/24 00:00 [pmc-release] AID - 10.1038/s41598-025-21296-9 [pii] AID - 21296 [pii] AID - 10.1038/s41598-025-21296-9 [doi] PST - epublish SO - Sci Rep. 2025 Oct 24;15(1):37249. doi: 10.1038/s41598-025-21296-9. PMID- 41134818 OWN - NLM STAT- MEDLINE DCOM- 20260213 LR - 20260721 IS - 1748-3115 (Electronic) IS - 1748-3107 (Linking) VI - 21 IP - 2 DP - 2026 Feb TI - The assessment of stationary and locomotion physical behavior using a single versus dual wearable accelerometer in children who use a manual wheelchair. PG - 530-542 LID - 10.1080/17483107.2025.2541044 [doi] AB - AIMS: Wearable devices such as activity monitors can be used to gain insight into children's physical behavior. However, children who are unable to walk are often excluded from validation studies, and therefore, robust information about their physical behavior is lacking. Therefore, we studied the criterion validity of a wearable prototype activity monitor (AM-p) in children who use a manual wheelchair with and without the ability to walk. METHODS: We analyzed the data for both single-sensor (sensor placement on upper arm or ankle) and dual-sensor use. Therefore, we conducted a study with cross-sectional design, assessing 37 children (12 girls) aged 6-19 years (mean 12 years, SD 4.3). Children wore an AM-p on the ankle and upper arm and were filmed while performing an activity protocol in a natural setting. Videos were labeled per 5-second epoch with individual activity labels. Raw data were synchronized with labels. An algorithm was trained, and labels were subdivided into pre-defined activity categories. Overall accuracy and F1 score (harmonic mean of precision and recall) were calculated per activity. FINDINGS: We demonstrate that the single ankle-worn AM-p can determine "stationary" behavior with excellent accuracy (>90%) and "locomotion" behavior with moderate to good accuracy (77-80%). "Locomotion" behavior includes active wheelchair use of children, which can assist pediatric physical therapists (PPTs) to assess physical behavior correctly in children who use a manual wheelchair. Exploratory analyses indicate that "locomotion" behavior (dual-sensor use), can be divided into "leg activity" and "active wheelchair use" for children who use a manual wheelchair and have the ability to walk. CONCLUSIONS: The single ankle-worn AM-p can determine "stationary" behavior with excellent accuracy and "locomotion" behavior with moderate to good accuracy in children who use a manual wheelchair in daily living. Our findings can assist PPTs to assess physical behavior correctly and tailor individual treatment plans. FAU - Engels, Barbara AU - Engels B AD - Research Centre Healthy and Sustainable Living, Research group Moving, Growing, and Thriving Together, Utrecht University of Applied Sciences, Utrecht, The Netherlands. AD - Research Centre Healthy and Sustainable Living, Research group Lifestyle and Health, Utrecht University of Applied Sciences, Utrecht, The Netherlands. AD - UMC Utrecht Brain Center and Center of Excellence for Rehabilitation Medicine, Utrecht University, Utrecht, The Netherlands. FAU - Bloemen, Manon A T AU - Bloemen MAT AD - Research Centre Healthy and Sustainable Living, Research group Moving, Growing, and Thriving Together, Utrecht University of Applied Sciences, Utrecht, The Netherlands. AD - Research Centre Healthy and Sustainable Living, Research group Lifestyle and Health, Utrecht University of Applied Sciences, Utrecht, The Netherlands. FAU - Felius, Richard AU - Felius R AD - Research Centre Healthy and Sustainable Living, Research group Lifestyle and Health, Utrecht University of Applied Sciences, Utrecht, The Netherlands. AD - Association for Quality in Physical Therapy (SKF), Zwolle, The Netherlands. FAU - Bolster, Eline A M AU - Bolster EAM AD - Research Centre Healthy and Sustainable Living, Research group Moving, Growing, and Thriving Together, Utrecht University of Applied Sciences, Utrecht, The Netherlands. AD - Research Centre Healthy and Sustainable Living, Research group Lifestyle and Health, Utrecht University of Applied Sciences, Utrecht, The Netherlands. FAU - Wittink, Harriet AU - Wittink H AD - Research Centre Healthy and Sustainable Living, Research group Lifestyle and Health, Utrecht University of Applied Sciences, Utrecht, The Netherlands. FAU - Melchers, Iris M S AU - Melchers IMS AD - Research Centre Healthy and Sustainable Living, Research group Lifestyle and Health, Utrecht University of Applied Sciences, Utrecht, The Netherlands. FAU - Engelbert, Raoul H H AU - Engelbert RHH AD - Centre of Expertise Urban Vitality, Faculty of Health, Amsterdam University of Applied Sciences, Amsterdam, The Netherlands. AD - Department of Rehabilitation Medicine, Amsterdam UMC, Location University of Amsterdam, Amsterdam, The Netherlands. AD - Amsterdam Movement Sciences, Rehabilitation and Development, Amsterdam, The Netherlands. FAU - Gorter, Jan Willem AU - Gorter JW AD - UMC Utrecht Brain Center and Center of Excellence for Rehabilitation Medicine, Utrecht University, Utrecht, The Netherlands. AD - Department of Rehabilitation, Physical Therapy Science and Sports, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands. AD - CanChild, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. LA - eng PT - Journal Article DEP - 20251024 PL - England TA - Disabil Rehabil Assist Technol JT - Disability and rehabilitation. Assistive technology JID - 101255937 SB - IM MH - Humans MH - Child MH - *Wheelchairs MH - Female MH - Male MH - Cross-Sectional Studies MH - Adolescent MH - *Wearable Electronic Devices MH - *Accelerometry/instrumentation MH - Young Adult MH - *Locomotion/physiology MH - *Children with Disabilities/rehabilitation OAB - A single ankle-worn activity monitor can determine and discriminate stationary and locomotion behavior in children with disabilities using a wheelchair. In addition, a dual system indicates a correct determination of stationary, leg activity, and active wheelchair use in children with and without the ability to walk.Assessment of physical behavior of children using a manual wheelchair in their everyday life provides insight in activity patterns which, in turn, can help therapists to engage with the child and family for optimal physical performance.By being able to differentiate between child-specific activities, including active and passive wheelchair use, long-term health outcomes and personalized treatment plans can be supported.This article reports on physical activity research in a population at high risk for sedentary behavior and poor health outcomes but often excluded in research. We, with this, promote equity in rehabilitation. OABL- eng OTO - NOTNLM OT - Wheelchair OT - activity monitor OT - developmental disability OT - pediatric physiotherapy OT - physical behavior OT - validity OT - wearable EDAT- 2025/10/24 18:27 MHDA- 2026/02/13 19:06 CRDT- 2025/10/24 13:43 PHST- 2026/02/13 19:06 [medline] PHST- 2025/10/24 18:27 [pubmed] PHST- 2025/10/24 13:43 [entrez] AID - 10.1080/17483107.2025.2541044 [doi] PST - ppublish SO - Disabil Rehabil Assist Technol. 2026 Feb;21(2):530-542. doi: 10.1080/17483107.2025.2541044. Epub 2025 Oct 24. PMID- 41134311 OWN - NLM STAT- MEDLINE DCOM- 20251202 LR - 20260531 IS - 1469-0705 (Electronic) IS - 0960-7692 (Print) IS - 0960-7692 (Linking) VI - 66 IP - 6 DP - 2025 Dec TI - Impact of fetal and maternal characteristics on the accuracy and precision of sonographic fetal weight estimation: population-based study. PG - 747-753 LID - 10.1002/uog.70117 [doi] AB - OBJECTIVE: Ultrasound-based fetal growth assessment is an essential part of clinical decision-making in modern obstetric care. This study aimed to evaluate the impact of maternal and fetal characteristics on the accuracy and precision of sonographic fetal weight estimation. METHODS: We included 31 521 singleton pregnancies registered in the Swedish Pregnancy Register between January 2014 and December 2021, with delivery >/= 22 + 0 weeks' gestation and estimated fetal weight (EFW) assessed using ultrasound within 2 days before delivery. Fetal biometric ultrasound measurements were used to calculate EFW according to the formula of Persson and Weldner. Mean percentage error (MPE) and the proportion of EFW within +/- 10% of the birth weight were calculated and stratified by maternal body mass index (BMI), fetal sex, fetal presentation at birth, gestational age (GA) at ultrasound and standardized EFW (estimated small-for-gestational age (SGA), appropriate-for-gestational age (AGA) or large-for-gestational age). Univariable and adjusted risk ratios (aRRs) for poor EFW assessment, defined as EFW deviating more than +/- 10% from the birth weight, were calculated. RESULTS: All investigated fetal characteristics, but not maternal BMI, affected the precision of EFW. The inaccuracies of fetal weight estimation were most pronounced in fetuses estimated as severe SGA (< 3(rd) percentile) across all subgroups of GA at ultrasound (overall MPE, -5.4 +/- 9.8%; 67% of estimates within +/- 10% of birth weight). The risk of poor fetal weight estimation was highest for severe-SGA-estimated vs AGA-estimated fetuses (aRR, 1.44 (95% CI, 1.38-1.51)). Additionally, the risk of poor fetal weight estimation was higher for male vs female fetuses (aRR, 1.09 (95% CI, 1.05-1.14)), non-cephalic vs cephalic presentation (aRR, 1.20 (95% CI, 1.13-1.28)) and preterm vs late term (39 + 0 to 40 + 6 weeks) GA at ultrasound, with the highest risk observed for those with GA of 22 + 0 to 27 + 6 weeks at ultrasound (aRR, 1.30 (95% CI, 1.13-1.50)). CONCLUSIONS: All assessed fetal characteristics, especially standardized EFW, affected the accuracy of ultrasonographic fetal weight estimation. Understanding systematic errors in the EFW formula used is of utmost importance in clinical decision-making to prevent unnecessary or missed obstetric interventions. (c) 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. CI - (c) 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. FAU - Granfors, M AU - Granfors M AUID- ORCID: 0000-0002-2925-3779 AD - Division of Clinical Epidemiology, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden. AD - Department of Women's Health, Division of Obstetrics, Karolinska University Hospital, Stockholm, Sweden. FAU - Mantel, A AU - Mantel A AD - Division of Clinical Epidemiology, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden. AD - Department of Women's Health, Division of Obstetrics, Karolinska University Hospital, Stockholm, Sweden. FAU - Axelsson, O AU - Axelsson O AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. AD - Centre for Clinical Research Sormland, Uppsala University, Eskilstuna, Sweden. FAU - Cnattingius, S AU - Cnattingius S AD - Division of Clinical Epidemiology, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden. FAU - Lindstrom, L AU - Lindstrom L AUID- ORCID: 0000-0003-4427-1075 AD - Division of Clinical Epidemiology, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden. AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. LA - eng GR - Swedish Infant Death Foundation (Spadbarnsfonden)/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251024 PL - England TA - Ultrasound Obstet Gynecol JT - Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology JID - 9108340 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Ultrasonography, Prenatal/statistics & numerical data/methods MH - *Fetal Weight MH - Sweden MH - Gestational Age MH - Adult MH - Birth Weight MH - Infant, Newborn MH - Male MH - Body Mass Index MH - Reproducibility of Results MH - Registries MH - Infant, Small for Gestational Age MH - Fetal Development PMC - PMC12671939 OTO - NOTNLM OT - accuracy OT - estimated fetal size OT - fetal presentation OT - fetal sex OT - fetal weight estimation OT - large-for-gestational age OT - precision OT - small-for-gestational age OT - ultrasound EDAT- 2025/10/24 12:31 MHDA- 2025/12/02 19:16 PMCR- 2025/12/02 CRDT- 2025/10/24 11:03 PHST- 2025/06/17 00:00 [revised] PHST- 2025/04/04 00:00 [received] PHST- 2025/09/03 00:00 [accepted] PHST- 2025/12/02 19:16 [medline] PHST- 2025/10/24 12:31 [pubmed] PHST- 2025/10/24 11:03 [entrez] PHST- 2025/12/02 00:00 [pmc-release] AID - UOG70117 [pii] AID - 10.1002/uog.70117 [doi] PST - ppublish SO - Ultrasound Obstet Gynecol. 2025 Dec;66(6):747-753. doi: 10.1002/uog.70117. Epub 2025 Oct 24. PMID- 41134114 OWN - NLM STAT- MEDLINE DCOM- 20251024 LR - 20251024 IS - 2204-2091 (Electronic) IS - 2204-2091 (Linking) VI - 35 IP - 4 DP - 2025 Dec 10 TI - Development of a digital dashboard to address population-level obesity using electronic medical record data. LID - PU24029 [pii] LID - 10.1071/PU24029 [doi] AB - OBJECTIVES: (1) To safely extract electronic medical record data to co-produce a population health informatics dashboard for obesity. (2) To explore how a population health informatics dashboard for obesity might be translated into routine public health practice. METHODS: This mixed methods study was conducted in Queensland, Australia, with stakeholders (n = 27) according to the Three Horizons Framework for Digital Health Transformation. Horizon 1 established the digital infrastructure necessary for accessing routine electronic medical record data from inpatient, outpatient, emergency, and community encounters. Horizon 2 co-produced user requirements for a population health informatics dashboard and developed a proof of concept. Horizon 3 conducted usability testing to explore the theoretical feasibility of integrating the dashboard into practice. RESULTS: The Queensland Healthy Weight Dashboard is an interactive visualisation platform for obesity surveillance capable of using near-real-time electronic medical record data. We developed a proof of concept using a synthetic sample of 726,561 patients. Once commissioned, the dashboard will display aggregate, non-identifiable data from a total sample of >1 million patients with a measured body mass index across 71 facilities in Queensland, including 19 health services and at least 71 individual facilities that use the integrated electronic Medical Record. The dashboard can display near real-time (quarterly) data via descriptive analytics to (1) identify total raw counts and normalised values, (2) longitudinally track data, and (3) geographically heatmap obesity, overweight, and healthy weight rates, and stratify by time (2016-2022), gender, age (2-99 years), and location (geographical area, facility). Usability testing with public health practitioner end-users (n = 4) revealed above-average overall usability but mixed task-based usability. Practitioners were optimistic about integrating the dashboard into routine practice. CONCLUSION: We co-produced a population health informatics tool for obesity that can display hospital electronic medical record data in near real-time. With further validation and usability improvements, this tool can be translated into public health practice to guide obesity interventions. CI - (c) 2025 The Author(s) (or their employer(s)). Published by CSIRO Publishing. FAU - Canfell, Oliver J AU - Canfell OJ AD - Department of Nutritional Sciences, Faculty of Life Sciences and Medicine, King's College London, London SE1 9NH, UK. AD - School of Public Health, Faculty of Medicine, The University of Queensland, Herston, Qld, Australia. FAU - Burton-Jones, Andrew AU - Burton-Jones A AD - UQ Business School, Faculty of Business, Economics, and Law, The University of Queensland, St Lucia, Qld, Australia. FAU - Eakin, Elizabeth AU - Eakin E AD - School of Public Health, Faculty of Medicine, The University of Queensland, Herston, Qld, Australia. FAU - Woods, Leanna AU - Woods L AD - Queensland Digital Health Centre, Centre for Health Services Research, Faculty of Medicine, The University of Queensland, Herston, Qld, Australia. FAU - Macklin, Sophie AU - Macklin S AD - Queensland Digital Health Centre, Centre for Health Services Research, Faculty of Medicine, The University of Queensland, Herston, Qld, Australia. FAU - Austin, Jodie AU - Austin J AD - Queensland Digital Health Centre, Centre for Health Services Research, Faculty of Medicine, The University of Queensland, Herston, Qld, Australia. FAU - Philip, Reji AU - Philip R AD - Queensland Digital Health Centre, Centre for Health Services Research, Faculty of Medicine, The University of Queensland, Herston, Qld, Australia. FAU - Lim, Han Chang AU - Lim HC AD - Queensland Digital Health Centre, Centre for Health Services Research, Faculty of Medicine, The University of Queensland, Herston, Qld, Australia. FAU - Ahmed, Kazi Rumana AU - Ahmed KR AD - Queensland Digital Health Centre, Centre for Health Services Research, Faculty of Medicine, The University of Queensland, Herston, Qld, Australia. FAU - Slade, Christine AU - Slade C AD - Queensland Digital Health Centre, Centre for Health Services Research, Faculty of Medicine, The University of Queensland, Herston, Qld, Australia. AD - Institute of Teaching and Learning Innovation, The University of Queensland, St Lucia, Qld, Australia. FAU - Francis, Daniel AU - Francis D AD - Metro North Hospital and Health Service, Department of Health, Queensland Government, Herston, Qld, Australia. FAU - Sullivan, Clair AU - Sullivan C AD - Queensland Digital Health Centre, Centre for Health Services Research, Faculty of Medicine, The University of Queensland, Herston, Qld, Australia. AD - Metro North Hospital and Health Service, Department of Health, Queensland Government, Herston, Qld, Australia. LA - eng PT - Journal Article PL - Australia TA - Public Health Res Pract JT - Public health research & practice JID - 101648133 SB - IM MH - Humans MH - *Electronic Health Records MH - *Obesity/epidemiology/prevention & control MH - Queensland/epidemiology MH - Male MH - Female MH - Adult MH - Middle Aged MH - Body Mass Index MH - Adolescent MH - Aged MH - Young Adult OTO - NOTNLM OT - clinical dashboard OT - digital health OT - electronic medical records OT - health care professionals OT - obesity OT - population surveillance OT - public health informatics OT - routinely collected health data EDAT- 2025/10/24 12:30 MHDA- 2025/10/24 12:31 CRDT- 2025/10/24 09:43 PHST- 2024/08/13 00:00 [received] PHST- 2025/06/30 00:00 [accepted] PHST- 2025/10/24 12:31 [medline] PHST- 2025/10/24 12:30 [pubmed] PHST- 2025/10/24 09:43 [entrez] AID - 233553 [pii] AID - 10.1071/PU24029 [doi] PST - ppublish SO - Public Health Res Pract. 2025 Dec 10;35(4):PU24029. doi: 10.1071/PU24029. PMID- 41133337 OWN - NLM STAT- MEDLINE DCOM- 20251024 LR - 20251024 IS - 2245-1919 (Electronic) IS - 2245-1919 (Linking) VI - 72 IP - 11 DP - 2025 Oct 21 TI - Outcome of drug-induced sedation endoscopy in adults with obstructive sleep apnoea or snoring. LID - A04250284 [pii] LID - 10.61409/A04250284 [doi] AB - INTRODUCTION: First-line treatment for obstructive sleep apnoea (OSA) is continuous positive airway pressure (CPAP). However, adherence to CPAP is poor. Non-adherent patients may benefit from other treatment modalities. Drug-induced sedation endoscopy (DISE) is a validated tool to suggest individualised treatment options. This study aimed to investigate the outcome of DISE in patients with OSA or severe snoring. METHODS: Patients with OSA and/or snoring who had poor compliance with CPAP were included in a database from May 2020 to October 2022. The inclusion criteria were BMI less-than 35 kg/m2, age 18-65 years and no contraindications to propofol infusion. DISE was performed, and anatomic collapse during DISE was evaluated using the velum-oropharynx-tongue-base-epiglottis classification. Treatment suggestions were registered. RESULTS: The database included 190 referred patients, and 109 patients underwent DISE. Among these, 34 had mild OSA or snoring (Apnea-Hypopnea Index (AHI) less-than 15 events/hour)) and 75 had moderate-severe OSA (AHI >/= 15 events/hour). A total of 51% of patients were recommended sleep surgery, the most frequent being tonsillectomy. Surgery was recommended more among patients with AHI >/= 15 events/hour. CONCLUSIONS: DISE suggests a personalised treatment for eligible patients with OSA or severe snoring. When the DISE findings were considered, half of the patients were recommended for sleep surgery. The value of DISE in planning such surgery in this cohort needs to be determined. FUNDING: None. TRIAL REGISTRATION: The study was approved by the Institutional Review Board and the Scientific Ethical Committee of the Central Denmark Region (no: 1-10-72-228-17). CI - Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/. FAU - Krarup, Sofie AU - Krarup S AD - Faculty of Health, Aarhus University. FAU - Bertelsen, Jannik Buus AU - Bertelsen JB AD - University Clinic for Balance, Flavour and Sleep, ENT Department, Godstrup Hospital, Herning. FAU - Ovesen, Therese AU - Ovesen T AD - University Clinic for Balance, Flavour and Sleep, ENT Department, Godstrup Hospital, Herning. AD - Department of Clinical Medicine, Aarhus University, Denmark. FAU - Zainali-Gill, Kasra AU - Zainali-Gill K AD - University Clinic for Balance, Flavour and Sleep, ENT Department, Godstrup Hospital, Herning. LA - eng PT - Journal Article DEP - 20251021 PL - Denmark TA - Dan Med J JT - Danish medical journal JID - 101576205 RN - 0 (Hypnotics and Sedatives) RN - YI7VU623SF (Propofol) SB - IM MH - Humans MH - *Sleep Apnea, Obstructive/therapy/surgery MH - *Snoring/therapy/surgery MH - Adult MH - Male MH - Female MH - Middle Aged MH - *Endoscopy/methods MH - *Hypnotics and Sedatives/administration & dosage MH - Aged MH - Propofol/administration & dosage MH - Young Adult MH - Treatment Outcome MH - Adolescent MH - Continuous Positive Airway Pressure EDAT- 2025/10/24 06:26 MHDA- 2025/10/24 12:30 CRDT- 2025/10/24 05:23 PHST- 2025/10/24 12:30 [medline] PHST- 2025/10/24 06:26 [pubmed] PHST- 2025/10/24 05:23 [entrez] AID - A04250284 [pii] AID - 10.61409/A04250284 [doi] PST - epublish SO - Dan Med J. 2025 Oct 21;72(11):A04250284. doi: 10.61409/A04250284. PMID- 41132343 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251024 LR - 20251027 IS - 2223-4691 (Print) IS - 2223-4691 (Electronic) IS - 2223-4683 (Linking) VI - 14 IP - 9 DP - 2025 Sep 30 TI - Ultrasound combined with multiple parameters for predicting stress urinary incontinence in women. PG - 2622-2634 LID - 10.21037/tau-2025-366 [doi] AB - BACKGROUND: Urinary incontinence is a disease that can be easily neglected but affects women's health, with stress urinary incontinence (SUI) being the most common type. We analyzed multiple parameters, including medical history, physical examination, surface electromyography, and pelvic floor ultrasound findings, to identify factors associated with SUI and its severity and integrated these factors into predictive models. METHODS: In this retrospective study, a consecutive series of women admitted to Chenghua District Maternal and Child Health Hospital (Chengdu, China) between November 2022 and February 2024 were stratified according to whether they were diagnosed with SUI or not (with 249 cases in each group). Patients with SUI were further stratified by the Ingelman-Sundberg hierarchical method and 1-hour urinary pad test. Results from medical history, physical examination, surface electromyography, and pelvic floor ultrasonography were compared between the different groups, and multivariate regression models were derived to predict the risk of SUI among all study participants or to distinguish the severity of the condition in the participants. Diagnostic performance of the models was assessed in terms of the area under the receiver operating characteristic curve (AUC). According to the same inclusion and exclusion criteria, 74 patients with non-SUI and 46 patients with SUI from the same medical center between April and June 2025 were recruited into an external validation set. RESULTS: We constructed a model that incorporated age, gravida, parity, bladder neck position, levator hiatus area, bladder neck descent, body mass index, delivery mode, pelvic floor muscle strength, point anterior wall point A (Aa) position, phasic contractions, tonic contractions, variability, urethral rotation angle, and posterior urethrovesical angle to predict SUI, which achieved an AUC of 0.861 [95% confidence interval (CI): 0.829-0.893]. Another model, which incorporated age, gravida, parity, bladder neck position, levator hiatus area, and bladder neck descent, could distinguish the severity of SUI, with an AUC of 0.783 (95% CI: 0.742-0.822). CONCLUSIONS: The combined model is reasonably reliable in predicting the risk of SUI but slightly less reliable for distinguishing its severity. CI - Copyright (c) 2025 AME Publishing Company. All rights reserved. FAU - Ren, Yangyang AU - Ren Y AD - Department of Obstetrics and Gynecology, Chengdu Chenghua District Maternal and Child Health Hospital, Chengdu, China. FAU - Hu, Rong AU - Hu R AD - Department of Ultrasonography, West China Second University Hospital, Sichuan University and Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. FAU - Yue, Siyu AU - Yue S AD - Department of Ultrasonography, Chengdu Chenghua District Maternal and Child Health Hospital, Chengdu, China. FAU - Yao, Yuan AU - Yao Y AD - Department of Gynecology, West China Second University Hospital, Sichuan University and Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. FAU - Yang, Fan AU - Yang F AD - Department of Ultrasonography, West China Second University Hospital, Sichuan University and Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. AD - Department of Administration, Chengdu Chenghua District Maternal and Child Health Hospital, Chengdu, China. LA - eng PT - Journal Article DEP - 20250926 PL - China TA - Transl Androl Urol JT - Translational andrology and urology JID - 101581119 PMC - PMC12541506 OTO - NOTNLM OT - Pelvic organ prolapse OT - Valsalva maneuver OT - electromyography OT - pelvic floor OT - ultrasonography COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tau.amegroups.com/article/view/10.21037/tau-2025-366/coif). The authors have no conflicts of interest to declare. EDAT- 2025/10/24 06:26 MHDA- 2025/10/24 06:27 PMCR- 2025/09/30 CRDT- 2025/10/24 04:45 PHST- 2025/05/23 00:00 [received] PHST- 2025/08/17 00:00 [accepted] PHST- 2025/10/24 06:27 [medline] PHST- 2025/10/24 06:26 [pubmed] PHST- 2025/10/24 04:45 [entrez] PHST- 2025/09/30 00:00 [pmc-release] AID - tau-14-09-2622 [pii] AID - 10.21037/tau-2025-366 [doi] PST - ppublish SO - Transl Androl Urol. 2025 Sep 30;14(9):2622-2634. doi: 10.21037/tau-2025-366. Epub 2025 Sep 26. PMID- 41131085 OWN - NLM STAT- MEDLINE DCOM- 20251023 LR - 20251124 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Oct 23 TI - Feasibility and safety of sailing based rehabilitation for rare skeletal disorders using wearable sensors and patient reported outcomes. PG - 37153 LID - 10.1038/s41598-025-22231-8 [doi] LID - 37153 AB - Rare skeletal disorders (RSDs) cause disability, pain, and reduced quality of life (QoL), with limited access to effective rehabilitation. This pilot study evaluated the feasibility, safety, and preliminary effects of a sailing-based rehabilitation program for adolescents with RSDs, integrating wearable inertial sensors and validated patient-reported outcomes. Eight adolescents (12-18 years) with RSDs participated in a five-day sailing intervention focused on physical activity, social interaction, and psychological reflection. Feasibility (recruitment, retention, adherence, acceptability) and safety (adverse events) were primary outcomes. Secondary measures included QoL (EuroQol 5-Dimension), psychological well-being (Pediatric Outcomes Data Collection Instrument, Rosenberg Self-Esteem Scale, Young Persons-Clinical Outcomes in Routine Evaluation, Tampa Scale of Kinesiophobia), and physical function assessed using inertial measurement units. All feasibility criteria met or exceeded: 100% retention and adherence, and high acceptability (mean score 3,75, SD = 0,46). No serious adverse events occurred. Significant benefits were found in proprioception (p = 0.01), postural control (p = 0.01), gait quality (p = 0.04), and upper limb function (p = 0.02). Trends toward improved QoL (EuroQol 5-Dimension Visual Analogue Scale, p = 0.10), happiness (Pediatric Outcomes Data Collection Instrument, p = 0.06), and reduced kinesiophobia (Tampa Scale of Kinesiophobia, p = 0.03) were observed. Some effects declined at follow-up. Sailing-based rehabilitation appears feasible, safe, and potentially effective for improving physical and psychological outcomes in RSDs. These findings support the development of larger controlled trials.Trial registration: ClinicalTrials.gov NCT06397443; release date: May 2, 2024. CI - (c) 2025. The Author(s). FAU - Boarini, Manila AU - Boarini M AD - Department of Rare Skeletal Disorders, IRCCS Istituto Ortopedico Rizzoli, 40136, Bologna, Italy. FAU - Banchelli, Federico AU - Banchelli F AD - Department of Rare Skeletal Disorders, IRCCS Istituto Ortopedico Rizzoli, 40136, Bologna, Italy. FAU - Fittipaldi, Silvia AU - Fittipaldi S AD - Department of Rare Skeletal Disorders, IRCCS Istituto Ortopedico Rizzoli, 40136, Bologna, Italy. FAU - Scognamiglio, Davide AU - Scognamiglio D AD - Department of Rare Skeletal Disorders, IRCCS Istituto Ortopedico Rizzoli, 40136, Bologna, Italy. FAU - Farella, Giuseppina M AU - Farella GM AUID- ORCID: 0000-0002-3153-3737 AD - Physical Medicine and Rehabilitation Unit 1, IRCCS Istituto Ortopedico Rizzoli, 40136, Bologna, Italy. giuseppinamariagrazia.farella@ior.it. FAU - Platano, Daniela AU - Platano D AD - Physical Medicine and Rehabilitation Unit 1, IRCCS Istituto Ortopedico Rizzoli, 40136, Bologna, Italy. AD - Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126, Bologna, Italy. FAU - Rogati, Giulia AU - Rogati G AUID- ORCID: 0000-0001-9301-9461 AD - Movement Analysis Laboratory, IRCCS Istituto Ortopedico Rizzoli, 40136, Bologna, Italy. giulia.rogati@ior.it. FAU - Di Sipio, Enrica AU - Di Sipio E AD - Euleria srl Societa Benefit, 38068, Rovereto (Trento), Italy. FAU - Villa, Giacomo AU - Villa G AD - Euleria srl Societa Benefit, 38068, Rovereto (Trento), Italy. AD - Department of Electronics, Information and Bioengineering (DEIB), Politecnico di Milano, 20133, Milan, Italy. FAU - Berti, Lisa AU - Berti L AD - Physical Medicine and Rehabilitation Unit 1, IRCCS Istituto Ortopedico Rizzoli, 40136, Bologna, Italy. AD - Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126, Bologna, Italy. FAU - Leardini, Alberto AU - Leardini A AD - Movement Analysis Laboratory, IRCCS Istituto Ortopedico Rizzoli, 40136, Bologna, Italy. FAU - Sartini, Silvana AU - Sartini S AD - Physical Medicine and Rehabilitation Unit 2, IRCCS Istituto Ortopedico Rizzoli, 40136, Bologna, Italy. FAU - Scopinaro, Annalisa AU - Scopinaro A AD - Italian Federation of Rare Diseases Patients Associations (UNIAMO FIMR), 00161, Rome, Italy. FAU - Sangiorgi, Luca AU - Sangiorgi L AD - Department of Rare Skeletal Disorders, IRCCS Istituto Ortopedico Rizzoli, 40136, Bologna, Italy. LA - eng SI - ClinicalTrials.gov/NCT06397443 GR - 8558/King Baudouin Foundation United States/ PT - Clinical Trial PT - Journal Article DEP - 20251023 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Exercise MH - Feasibility Studies MH - *Patient Reported Outcome Measures MH - Pilot Projects MH - Quality of Life MH - *Wearable Electronic Devices MH - Longitudinal Studies MH - *Occupational Therapy/instrumentation/methods MH - *Rare Diseases/rehabilitation MH - *Bone Diseases/rehabilitation PMC - PMC12549867 OTO - NOTNLM OT - Feasibility and safety OT - HRQoL OT - Patient-reported outcomes OT - Rare skeletal disorders OT - Sailing-based rehabilitation OT - Wearable sensors COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical statement and informed consent: The study was approved by the Local Ethical Committee, Comitato Etico Area Vasta Emilia Centro (CE-AVEC), under protocol number: 115/2024/Sper/IOR, and conducted in accordance with the 1964 Declaration of Helsinki. Written informed consent was obtained from all participants aged >/= 18 years and from parents/guardians of those participants aged < 18 years. EDAT- 2025/10/24 00:26 MHDA- 2025/10/24 00:27 PMCR- 2025/10/23 CRDT- 2025/10/23 23:28 PHST- 2025/05/27 00:00 [received] PHST- 2025/09/26 00:00 [accepted] PHST- 2025/10/24 00:27 [medline] PHST- 2025/10/24 00:26 [pubmed] PHST- 2025/10/23 23:28 [entrez] PHST- 2025/10/23 00:00 [pmc-release] AID - 10.1038/s41598-025-22231-8 [pii] AID - 22231 [pii] AID - 10.1038/s41598-025-22231-8 [doi] PST - epublish SO - Sci Rep. 2025 Oct 23;15(1):37153. doi: 10.1038/s41598-025-22231-8. PMID- 41130434 OWN - NLM STAT- MEDLINE DCOM- 20251113 LR - 20260711 IS - 1873-507X (Electronic) IS - 0031-9384 (Linking) VI - 303 DP - 2026 Jan 1 TI - Boredom, interoceptive ability, and emotional eating: An experimental study. PG - 115137 LID - S0031-9384(25)00338-5 [pii] LID - 10.1016/j.physbeh.2025.115137 [doi] AB - Growing evidence underscores the importance of examining specific emotions to better understand emotional eating. Boredom is one such underexplored emotion, and little is known about individual differences that may increase vulnerability to "bored eating." Given the relevance of interoception-awareness of internal bodily signals-to other forms of dysregulated eating, the current study investigated whether interoceptive ability moderates the relationship between boredom and food consumption. In a controlled laboratory experiment, 187 participants consumed a water preload and were randomly assigned to a 30-minute boredom or neutral condition. Snack foods (chocolate, crackers, chips) were available ad libitum, and consumption was covertly measured. Interoception was assessed via general interoceptive sensibility, hunger/satiety-specific sensibility, and gastric interoceptive sensitivity using the two-step Water Load Test. Analyses of covariance tested main and interaction effects of condition and interoceptive measures on food consumption. Contrary to hypotheses, neither boredom nor any interoceptive measure predicted total or food-type-specific consumption. Additionally, interoception did not moderate the relationship between boredom and eating. These findings contribute to a growing body of research questioning the predictive validity of self-reported emotional eating and highlight the importance of distinguishing between self-reported tendencies and observable behavior. Future research using ecologically valid, longitudinal methods may help clarify when and for whom boredom contributes to dysregulated eating and whether physiological awareness influences this pathway. CI - Copyright (c) 2025. Published by Elsevier Inc. FAU - Ahlich, Erica AU - Ahlich E AD - Department of Psychology, University of South Alabama, UCOM 1000, 75 South University Blvd., Mobile, AL 36688, USA. Electronic address: eahlich@southalabama.edu. FAU - Poovey, Kendall AU - Poovey K AD - University of South Florida, Tampa, FL 33620, USA. Electronic address: knpoovey@usf.edu. FAU - Cunning, Allison AU - Cunning A AD - University of South Florida, Tampa, FL 33620, USA. Electronic address: allisoncunning@usf.edu. FAU - Boyajian, Laura AU - Boyajian L AD - University of South Florida, Tampa, FL 33620, USA. Electronic address: boyajianl@usf.edu. FAU - Rancourt, Diana AU - Rancourt D AD - University of South Florida, Tampa, FL 33620, USA. Electronic address: drancourt@usf.edu. LA - eng PT - Journal Article DEP - 20251021 PL - United States TA - Physiol Behav JT - Physiology & behavior JID - 0151504 SB - IM MH - Humans MH - Female MH - Male MH - *Interoception/physiology MH - Young Adult MH - *Emotions/physiology MH - *Eating/psychology/physiology MH - *Boredom MH - Adult MH - *Feeding Behavior/psychology/physiology MH - Adolescent MH - Emotional Eating OTO - NOTNLM OT - Affect OT - Boredom OT - Eating behavior OT - Emotional eating OT - Experimental design OT - Interoception COIS- Declaration of competing interest The authors report no conflicts of interest related to this research. EDAT- 2025/10/24 00:26 MHDA- 2025/11/13 18:30 CRDT- 2025/10/23 19:35 PHST- 2025/06/23 00:00 [received] PHST- 2025/09/09 00:00 [revised] PHST- 2025/10/20 00:00 [accepted] PHST- 2025/11/13 18:30 [medline] PHST- 2025/10/24 00:26 [pubmed] PHST- 2025/10/23 19:35 [entrez] AID - S0031-9384(25)00338-5 [pii] AID - 10.1016/j.physbeh.2025.115137 [doi] PST - ppublish SO - Physiol Behav. 2026 Jan 1;303:115137. doi: 10.1016/j.physbeh.2025.115137. Epub 2025 Oct 21. PMID- 41129204 OWN - NLM STAT- MEDLINE DCOM- 20260306 LR - 20260923 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) VI - 37 IP - 3-4 DP - 2026 Mar-Apr 01 TI - Anthropometry of Nose-Defining Normalcy and Guiding Esthetics for the Central India Population. PG - e201-e205 LID - 10.1097/SCS.0000000000012109 [doi] AB - Nasal anthropometry is important for rhinoplasty planning and gender-affirming surgeries, which gives a comprehensive view of the Central Indian population concerning the same. The study aims to quantify nasal anthropometry in the Central Indian population against methods of measurement derived parameters for males and females, and to test the validity of the neoclassical canon. A cross-sectional study of 200 individuals (61 females, 141 males) from Central India. Fourteen linear measurements, 2 angular measurements, and 13 proportional indices were obtained using manual anthropometry and 2D photogrammetry. From 20 parameters, 71.42% showed significant differences between the means of both methods, whereby the manual measures for 11.2% less than the photogrammetric values. The nasal bridge length was found to differ between 40.55+/-3.68 mm versus 48.63+/-10.42 mm ( P <0.0001). Males recorded significantly larger measurements for 78.6% of linear parameters (11/14), which included nasal width (37.70 mm versus 34.75 mm, P <0.0001). Neoclassical canon failed to prove valid for 98.5% to 100% of subjects: naso-facial proportion achieved a 1:1 ratio in only 1% (manual) and 1.5% (photogrammetric); orbital proportion in 1% and 0.5%, respectively; orbito-nasal proportion in 0% for both methods. The population displayed predominantly mesorrhine (nasal index: 0.79 manual, 0.85 photogrammetric) nasal morphology. Population-specific anthropometric norms would give surgeons a more accurate account for optimizing outcomes in rhinoplasties and hopefully reducing the rates of revision by culturally relevant surgical planning. CI - Copyright (c) 2025 by Mutaz B. Habal, MD. FAU - Fidvi, Al Iqyan AU - Fidvi AI AD - Department of Burns and Plastic Surgery. FAU - Jain, Tanul AU - Jain T AD - AIIMS. FAU - Lakshmi N R, Aiswarya AU - Lakshmi N R A AD - Department of Community Medicine, AIIMS Nagpur, MIHAN, Nagpur. FAU - Aditya, Woonna S AU - Aditya WS AD - AIIMS. FAU - Abigail, Bukya AU - Abigail B AD - AIIMS. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251023 PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 SB - IM MH - Humans MH - Male MH - Female MH - India MH - Cross-Sectional Studies MH - Photogrammetry MH - *Anthropometry/methods MH - *Nose/anatomy & histology MH - Adult MH - *Esthetics MH - *Rhinoplasty MH - Middle Aged MH - Adolescent OTO - NOTNLM OT - Gender dimorphism OT - nasal anthropometry OT - neoclassical canons OT - photogrammetry COIS- The authors report no conflicts of interest. EDAT- 2025/10/23 12:28 MHDA- 2026/03/07 01:38 CRDT- 2025/10/23 11:53 PHST- 2025/09/05 00:00 [received] PHST- 2025/09/26 00:00 [accepted] PHST- 2026/03/07 01:38 [medline] PHST- 2025/10/23 12:28 [pubmed] PHST- 2025/10/23 11:53 [entrez] AID - 00001665-202603000-00141 [pii] AID - 10.1097/SCS.0000000000012109 [doi] PST - ppublish SO - J Craniofac Surg. 2026 Mar-Apr 01;37(3-4):e201-e205. doi: 10.1097/SCS.0000000000012109. Epub 2025 Oct 23. PMID- 41129144 OWN - NLM STAT- MEDLINE DCOM- 20260106 LR - 20261015 IS - 2374-2445 (Electronic) IS - 2374-2437 (Print) IS - 2374-2437 (Linking) VI - 11 IP - 12 DP - 2025 Dec 1 TI - Risk Prediction Model for Development of Heart Failure or Cardiomyopathy After Breast Cancer Treatment. PG - 1479-1487 LID - 10.1001/jamaoncol.2025.4178 [doi] AB - IMPORTANCE: Women receiving breast cancer (BC) treatment are at risk for heart failure or cardiomyopathy (HF/CM). No standard method exists to identify women at risk who might benefit from preventive cardiac strategies and surveillance during and after treatment. OBJECTIVE: To develop and validate a model predicting the 10-year risk of developing HF/CM in women receiving systemic treatment for invasive early-stage BC to inform cardiac risk management. DESIGN, SETTING, AND PARTICIPANTS: This longitudinal cohort study of patients cared for in Kaiser Permanente Southern California, a vertically integrated health care system. The goal of the study was to predict the 10-year HF/CM risk using multivariable elastic-net Cox proportional hazards models. Women aged 18 to 79 years with newly diagnosed invasive local or regional BC from 2008 to 2020, with a median follow-up of 5.2 years, were included. The cohort was randomly split into derivation (60%) and validation (40%) cohorts. Data were analyzed from April 2024 to May 2025. EXPOSURES: HF/CM risk predictors included age at BC diagnosis, race and ethnicity, area-level socioeconomic status, local and systemic BC treatments, cancer stage, obesity, and history of hypertension, diabetes, hyperlipidemia, smoking, and other CV conditions. MAIN OUTCOME AND MEASURES: Incident HF/CM events. Women were categorized into low-, moderate-, and high-risk groups based on the tertiles of the risk score in the derivation cohort. RESULTS: Of 26 044 women included in the total cohort, the median (IQR) age was 61 (52-68) years. The risk model had good calibration and high accuracy in predicting HF/CM risk in the 3 subgroups, with HF/CM risk in the validation cohort matching the estimates from the derivation for identifying women at low risk (1.7%; 95% CI, 1.1%-2.4%) and high risk (19.4%; 95% CI. 17.3%-21.5%) of HF/CM at 10 years. The model's discrimination ability was good, based on the time-dependent area under the curve of 0.79 at 10 years in the validation cohort. CONCLUSIONS AND RELEVANCE: This risk prediction model among women with early-stage BC was able to prospectively identify those at risk of HF/CM over a 10-year period based on the selected BC treatment and clinical variables available at BC diagnosis. The model can be used to inform risk-guided cardiac management for these women. FAU - Barac, Ana AU - Barac A AD - Inova Schar Heart and Vascular, Fairfax, Virginia. AD - Georgetown University Medical Center, Washington, DC. FAU - Chou, Jiling AU - Chou J AD - MedStar Health Research Institute, Columbia, Maryland. FAU - Shara, Nawar AU - Shara N AD - MedStar Health Research Institute, Columbia, Maryland. FAU - Chen, Lie H AU - Chen LH AD - Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena. FAU - Shi, Jiaxiao AU - Shi J AD - Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena. FAU - Chlebowski, Rowan T AU - Chlebowski RT AD - The Lundquist Institute, Torrance, California. FAU - Mukherjee, Amrita AU - Mukherjee A AD - Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena. FAU - Haque, Reina AU - Haque R AD - Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena. AD - Department of Health Systems Science, Kaiser Permanente School of Medicine, Pasadena, California. FAU - Potosky, Arnold L AU - Potosky AL AD - Cancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC. LA - eng GR - P30 CA051008/CA/NCI NIH HHS/United States GR - R01 HL154319/HL/NHLBI NIH HHS/United States PT - Journal Article PL - United States TA - JAMA Oncol JT - JAMA oncology JID - 101652861 SB - IM CIN - JAMA Oncol. 2025 Dec 1;11(12):1426-1428. doi: 10.1001/jamaoncol.2025.4141. PMID: 41129121 MH - Humans MH - Female MH - *Breast Neoplasms/therapy/pathology/drug therapy MH - Middle Aged MH - *Heart Failure/epidemiology/etiology MH - Adult MH - *Cardiomyopathies/epidemiology/etiology/chemically induced MH - Aged MH - Risk Assessment MH - Young Adult MH - Longitudinal Studies MH - Adolescent MH - Risk Factors MH - Proportional Hazards Models PMC - PMC12550738 MID - NIHMS2211824 COIS- Conflict of Interest Disclosures: Dr Chlebowski reported personal fees from UpToDate and Pfizer during the conduct of the study. No other disclosures were reported. EDAT- 2025/10/23 12:28 MHDA- 2026/01/06 19:17 PMCR- 2026/10/23 CRDT- 2025/10/23 11:33 PHST- 2026/01/06 19:17 [medline] PHST- 2025/10/23 12:28 [pubmed] PHST- 2025/10/23 11:33 [entrez] PHST- 2026/10/23 00:00 [pmc-release] AID - 2840215 [pii] AID - coi250064 [pii] AID - 10.1001/jamaoncol.2025.4178 [doi] PST - ppublish SO - JAMA Oncol. 2025 Dec 1;11(12):1479-1487. doi: 10.1001/jamaoncol.2025.4178. PMID- 41126288 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251023 LR - 20251027 IS - 2055-0928 (Electronic) IS - 2055-0928 (Linking) VI - 11 IP - 1 DP - 2025 Oct 22 TI - Assessing weight stigma in school-aged children (grades 1 to 3): a cross-sectional study from Palestine. PG - 192 LID - 10.1186/s40795-025-01179-y [doi] LID - 192 AB - BACKGROUND: Obesity is a complex global epidemic. There are multiple causes and complications of obesity, both physical and psychological ones. One challenge that individuals with obesity encounter is the experience of weight stigma. Weight stigma is associated with negative outcomes, including psychological disturbances, eating disorders, weight gain, and avoiding physical activity. Weight stigma is prevalent among different age groups. The main purpose of the study is to explore weight stigma among school-aged children through the development of an image-based questionnaire. This study is conducted as a first step for further educational intervention studies to reduce weight stigma among children. METHODS: The study aimed to explore weight stigma in 150 children aged 6 to 9 years through direct interviews conducted by the researcher. Data collection started after the development and validation of a specific image-based questionnaire. Questionnaire development followed an intense literature review. Content validity was ensured by revision from experts in related fields. Reliability was checked by a pilot study, followed by data analysis to calculate Cronbach's alpha. Weight stigma explored through a) stereotypes of others with obesity. b) social preference and rejection of individuals with obesity. c) children's beliefs about weight controllability and judgment towards others with obesity. Based on that, the developed questionnaire was composed of three tasks: the Adjective Attribution Task, the Friendship Selection Task, and the Controllability Task. RESULTS: In the Adjective Attribution Task, most of the participants attributed negative adjectives to the figure with overweight. In the Friendship Selection Task, figures with overweight were almost rejected as partners and friends, and only one child chose the figure with overweight as a best friend. The Controllability Task revealed a high percentage of judgment beliefs towards figures with overweight. CONCLUSION: Our findings indicate that weight stigma is prevalent among school-aged children. This study is the first to provide a tool to explore weight stigma and to offer statistical data that will support future educational interventions. This work is important to reduce weight stigma among children, protect children's psychological status, reduce obesity prevalence, and improve its management. CI - (c) 2025. The Author(s). FAU - Bustami, Lina AU - Bustami L AD - Department of Nutrition and Food Technology, Faculty of Agriculture and Veterinary Medicine, An-Najah National University, Tulkarm, West Bank, Palestine. FAU - Badrasawi, Manal AU - Badrasawi M AD - Department of Nutrition and Food Technology, Faculty of Agriculture and Veterinary Medicine, An-Najah National University, Tulkarm, West Bank, Palestine. FAU - Anabtawi, Ola AU - Anabtawi O AD - Department of Nutrition and Food Technology, Faculty of Agriculture and Veterinary Medicine, An-Najah National University, Tulkarm, West Bank, Palestine. ola.anabtawi@najah.edu. LA - eng PT - Journal Article DEP - 20251022 PL - England TA - BMC Nutr JT - BMC nutrition JID - 101672434 PMC - PMC12542446 OTO - NOTNLM OT - Child OT - Pediatric obesity OT - Psychometrics OT - Questionnaires OT - Weight Prejudice COIS- Declarations. Ethics approval and consent to participate: The study protocol was approved by the Institutional Review Board at An-Najah National University. Permissions and approval to conduct the study were obtained from Pioneers Baccalaureate, Ithar, and UNRWA schools. Assigned formal consent was obtained from the parents of the participants, and verbal consent was obtained from all the participants prior to data collection. The study was conducted in accordance with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/10/23 06:28 MHDA- 2025/10/23 06:29 PMCR- 2025/10/22 CRDT- 2025/10/23 00:02 PHST- 2025/06/23 00:00 [received] PHST- 2025/09/22 00:00 [accepted] PHST- 2025/10/23 06:29 [medline] PHST- 2025/10/23 06:28 [pubmed] PHST- 2025/10/23 00:02 [entrez] PHST- 2025/10/22 00:00 [pmc-release] AID - 10.1186/s40795-025-01179-y [pii] AID - 1179 [pii] AID - 10.1186/s40795-025-01179-y [doi] PST - epublish SO - BMC Nutr. 2025 Oct 22;11(1):192. doi: 10.1186/s40795-025-01179-y. PMID- 41125609 OWN - NLM STAT- MEDLINE DCOM- 20251022 LR - 20251025 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Oct 22 TI - Quantifying child growth effects using height-age instead of height-for-age z-scores in a meta-analysis of small-quantity lipid-based nutrient supplement trials. PG - 36853 LID - 10.1038/s41598-025-20664-9 [doi] LID - 36853 AB - Height-age is the age at which growth-faltered children's average observed height or length equals the median height or length of a child growth standard, corresponding to a length-for-age z-score (LAZ) of 0. In randomized controlled trials (RCTs) in low- and middle-income countries (LMICs), expression of linear growth outcomes using height-age may enhance the interpretability of intervention effects compared to conventional use of LAZ. Height-age can be used to derive the proportion of maximal benefit (PMB), whereby PMB = 0% indicates no effect and PMB = 100% indicates the intervention promoted growth at the rate expected for healthy children with the same starting height-age. In this proof-of-concept study, height-age and PMB were compared to LAZ in a meta-analysis of RCTs of small-quantity lipid-based nutrient supplements (SQ-LNS). Pooling across 15 trials in 10 LMICs, mean differences (MD; SQ-LNS minus control) in LAZ and height-age were 0.15 (95%CI: 0.12, 0.17) and 12 days (95%CI: 9, 14), respectively (N = 36,970). LAZ MD and height-age MD were highly correlated (rho = 0.74 overall and 0.94 upon exclusion of an outlier). The pooled PMB indicated that SQ-LNS achieves 11% of optimal growth potential (95% CI: [9.4, 12]; N = 19,768; 12 comparisons), but there was a substantial impact of between-trial heterogeneity (I(2) = 90%). In conclusion, the effect of SQ-LNS on linear growth can be alternatively expressed in terms of height-age instead of LAZ. The PMB may enhance the interpretability of effect estimates by quantifying the extent to which an intervention improves growth in relation to a biological threshold, but further research is required to establish its validity and usefulness for assessing and comparing intervention effectiveness. CI - (c) 2025. The Author(s). FAU - Watson, Kelly M AU - Watson KM AD - Centre for Global Child Health, The Hospital for Sick Children, 686 Bay St, Toronto, ON, M5G 0A4, Canada. AD - Department of Nutritional Sciences, University of Toronto, Toronto, Canada. FAU - Dasiewicz, Alison S B AU - Dasiewicz ASB AD - Centre for Global Child Health, The Hospital for Sick Children, 686 Bay St, Toronto, ON, M5G 0A4, Canada. FAU - Bassani, Diego G AU - Bassani DG AD - Centre for Global Child Health, The Hospital for Sick Children, 686 Bay St, Toronto, ON, M5G 0A4, Canada. AD - Department of Paediatrics, University of Toronto, Toronto, Canada. AD - Dalla Lana School of Public Health, University of Toronto, Toronto, Canada. FAU - Chen, Chun-Yuan AU - Chen CY AD - Centre for Global Child Health, The Hospital for Sick Children, 686 Bay St, Toronto, ON, M5G 0A4, Canada. FAU - Qamar, Huma AU - Qamar H AD - Centre for Global Child Health, The Hospital for Sick Children, 686 Bay St, Toronto, ON, M5G 0A4, Canada. FAU - Roth, Daniel E AU - Roth DE AD - Centre for Global Child Health, The Hospital for Sick Children, 686 Bay St, Toronto, ON, M5G 0A4, Canada. daniel.roth@sickkids.ca. AD - Department of Nutritional Sciences, University of Toronto, Toronto, Canada. daniel.roth@sickkids.ca. AD - Department of Paediatrics, University of Toronto, Toronto, Canada. daniel.roth@sickkids.ca. AD - Dalla Lana School of Public Health, University of Toronto, Toronto, Canada. daniel.roth@sickkids.ca. LA - eng GR - 169133/CAPMC/CIHR/Canada GR - 169133/CAPMC/CIHR/Canada PT - Journal Article PT - Meta-Analysis DEP - 20251022 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Lipids) SB - IM MH - Humans MH - *Body Height MH - *Dietary Supplements MH - *Child Development MH - *Lipids/administration & dosage MH - Child MH - Randomized Controlled Trials as Topic MH - Child, Preschool MH - Male MH - Infant MH - Female PMC - PMC12546833 OTO - NOTNLM OT - Child growth OT - Height-age OT - Height-for-age z-scores OT - Length-for-age z-scores OT - Low- and middle-income countries OT - Randomized controlled trials OT - Small-quantity lipid-based nutrient supplements COIS- Declarations. Competing interests: The authors declare that they have no competing interests. Ethical approval: Not applicable. Consent for publication: Not applicable. Consent to participate: Not applicable. EDAT- 2025/10/23 00:26 MHDA- 2025/10/23 00:27 PMCR- 2025/10/22 CRDT- 2025/10/22 23:17 PHST- 2025/06/17 00:00 [received] PHST- 2025/09/16 00:00 [accepted] PHST- 2025/10/23 00:27 [medline] PHST- 2025/10/23 00:26 [pubmed] PHST- 2025/10/22 23:17 [entrez] PHST- 2025/10/22 00:00 [pmc-release] AID - 10.1038/s41598-025-20664-9 [pii] AID - 20664 [pii] AID - 10.1038/s41598-025-20664-9 [doi] PST - epublish SO - Sci Rep. 2025 Oct 22;15(1):36853. doi: 10.1038/s41598-025-20664-9. PMID- 41125225 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251202 LR - 20251205 IS - 2713-4148 (Electronic) IS - 2713-4148 (Linking) VI - 68 IP - 12 DP - 2025 Dec TI - Exploring nutritional screening tools for hospitalized children: a narrative review. PG - 963-970 LID - 10.3345/cep.2025.00633 [doi] AB - Malnutrition is common among hospitalized children, especially those who are critically ill. Routine measures, such as anthropometric measurements, body composition, and nutritional assessment, comprise the basics of monitoring. This review discusses the adequacy of nutritional screening tools (NSTs) such as the SGNA (Subjective Global Nutritional Assessment), PYMS (Pediatric Yorkhill Malnutrition Score), STAMP (Screening Tool for the Assessment of Malnutrition in Paediatrics), and STRONGkids (Screening Tool for Risk of Nutritional Status and Growth). This review included recently published reports supporting the validation and implementation of NSTs in pediatric populations. A child's nutritional status during hospitalization is of great importance for their recovery, while the implementation of screening tools enhances their clinical outcomes. Current tools have varying sensitivities and specificities, and no single tool can be recommended for all groups of hospitalized children. A combination of tools or adaptation of existing tools with validation in different contexts might be ideal. Further studies are required to develop more robust and comprehensive screening tools. FAU - Soni, Pankaj AU - Soni P AD - Department of Neonatology, Thumbay University Hospital, and Clinical Lecturer, Department of Clinical Sciences (Pediatric Neonatology), College of Medicine, Gulf Medical University, Ajman, UAE. FAU - Agrawal, Amit AU - Agrawal A AD - Department of Pediatrics, Gandhi Medical College, Bhopal, India. FAU - Jadon, Gaurav AU - Jadon G AD - NMC Specialty Hospital, Dubai, UAE. LA - eng PT - Journal Article DEP - 20251022 PL - Korea (South) TA - Clin Exp Pediatr JT - Clinical and experimental pediatrics JID - 101761234 PMC - PMC12672397 OTO - NOTNLM OT - Child OT - Malnutrition OT - Nutritional assessment OT - Nutritional screening tools OT - Nutritional status COIS- Conflicts of interest No potential conflict of interest relevant to this article was reported. EDAT- 2025/10/23 00:26 MHDA- 2025/10/23 00:27 PMCR- 2025/10/22 CRDT- 2025/10/22 19:28 PHST- 2025/03/13 00:00 [received] PHST- 2025/08/22 00:00 [accepted] PHST- 2025/10/23 00:27 [medline] PHST- 2025/10/23 00:26 [pubmed] PHST- 2025/10/22 19:28 [entrez] PHST- 2025/10/22 00:00 [pmc-release] AID - cep.2025.00633 [pii] AID - cep-2025-00633 [pii] AID - 10.3345/cep.2025.00633 [doi] PST - ppublish SO - Clin Exp Pediatr. 2025 Dec;68(12):963-970. doi: 10.3345/cep.2025.00633. Epub 2025 Oct 22. PMID- 41124544 OWN - NLM STAT- MEDLINE DCOM- 20251022 LR - 20251027 IS - 1806-9282 (Electronic) IS - 0104-4230 (Print) IS - 0104-4230 (Linking) VI - 71 IP - 9 DP - 2025 TI - Predicting malaria in sudanese pregnant women: reliability of complete blood count. PG - e20250022 LID - S0104-42302025000900604 [pii] LID - 10.1590/1806-9282.20250022 [doi] LID - e20250022 AB - BACKGROUND: Malaria remains a major public health concern in tropical regions, especially among pregnant women. It increases the risk of maternal anemia, low birth weight, preterm delivery, and infant mortality. OBJECTIVE: The aim of this study was to assess the hematological effects of malaria during pregnancy and evaluate the diagnostic value of blood count parameters, particularly platelet distribution width, as a potential biomarker. METHODS: In this retrospective study, 174 pregnant women were included: 78 with confirmed malaria and 96 malaria-negative controls. Hematological parameters such as hemoglobin, white blood cell count, platelet count, platelet distribution width, and mean platelet volume were compared between the groups. Statistical analyses included univariate and multivariate logistic regression and receiver operating characteristic curve analysis. RESULTS: There were no significant differences between the groups in terms of age, gestational week, gravida, parity, abortion, white blood cell, or mean platelet volume. However, body mass index, hemoglobin, platelet, and platelet distribution width were significantly lower in the malaria group (p<0.05). While all the four parameters predicted malaria status in univariate analysis, only platelet distribution width remained significant in multivariate analysis. Platelet distribution width demonstrated the highest diagnostic accuracy (area under the curve=0.857). CONCLUSION: Platelet distribution width may serve as a reliable and accessible hematological marker for malaria in pregnancy, particularly in resource-limited settings. Routine evaluation of complete blood count parameters could support early diagnosis and improve maternal-fetal outcomes. FAU - Dura, Mustafa Cengiz AU - Dura MC AUID- ORCID: 0000-0003-4083-8556 AD - University of Health Sciences Turkey, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Department of Obstetrics and Gynecology - Istanbul, Turkey. FAU - Gursoy, Berk AU - Gursoy B AUID- ORCID: 0000-0002-9407-9420 AD - University of Health Sciences Turkey, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Department of Obstetrics and Gynecology - Istanbul, Turkey. FAU - Akturk, Hilal AU - Akturk H AUID- ORCID: 0000-0001-7984-9653 AD - Kahta State Hospital, Department of Obstetrics and Gynecology - Adiyaman, Turkey. FAU - Aslan, Ozgur AU - Aslan O AUID- ORCID: 0000-0002-7048-2100 AD - Mus State Hospital, Department of Obstetrics and Gynecology - Mus, Turkey. FAU - Herguner, Metehan AU - Herguner M AUID- ORCID: 0000-0003-3182-6430 AD - University of Health Sciences Turkey, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Department of Obstetrics and Gynecology - Istanbul, Turkey. FAU - Ezirmik, Elif AU - Ezirmik E AUID- ORCID: 0000-0001-6828-4378 AD - Karasu District Health Directorate, Department of Family Medicine - Karasu, Turkey. LA - eng PT - Journal Article DEP - 20251017 PL - Brazil TA - Rev Assoc Med Bras (1992) JT - Revista da Associacao Medica Brasileira (1992) JID - 9308586 RN - 0 (Biomarkers) RN - 0 (Hemoglobins) SB - IM MH - Humans MH - Female MH - Pregnancy MH - Retrospective Studies MH - Adult MH - *Malaria/diagnosis/blood MH - Sudan MH - Blood Cell Count/methods MH - Biomarkers/blood MH - *Pregnancy Complications, Parasitic/blood/diagnosis MH - Reproducibility of Results MH - Young Adult MH - Case-Control Studies MH - Predictive Value of Tests MH - Platelet Count MH - Hemoglobins/analysis MH - ROC Curve MH - Leukocyte Count MH - Mean Platelet Volume PMC - PMC12534071 COIS- Conflicts of interest: the authors declare there is no conflicts of interest. EDAT- 2025/10/22 18:26 MHDA- 2025/10/22 18:27 PMCR- 2025/10/17 CRDT- 2025/10/22 15:01 PHST- 2025/01/23 00:00 [received] PHST- 2025/06/09 00:00 [accepted] PHST- 2025/10/22 18:27 [medline] PHST- 2025/10/22 18:26 [pubmed] PHST- 2025/10/22 15:01 [entrez] PHST- 2025/10/17 00:00 [pmc-release] AID - S0104-42302025000900604 [pii] AID - 10.1590/1806-9282.20250022 [doi] PST - epublish SO - Rev Assoc Med Bras (1992). 2025 Oct 17;71(9):e20250022. doi: 10.1590/1806-9282.20250022. eCollection 2025. PMID- 41122977 OWN - NLM STAT- MEDLINE DCOM- 20260209 LR - 20260209 IS - 1098-108X (Electronic) IS - 0276-3478 (Linking) VI - 59 IP - 2 DP - 2026 Feb TI - Comparing Operationalizations of Eating Disorder Recovery Using a Comprehensive Lens: Physical, Behavioral, and Cognitive Domains. PG - 236-248 LID - 10.1002/eat.24559 [doi] AB - OBJECTIVE: A standardized definition of recovery would advance treatment outcome research. This study examined combinations of different physical, behavioral, and cognitive recovery criteria to identify the operationalization of eating disorder (ED) recovery with the most empirical support based on concurrent and predictive validity. METHOD: Participants included 223 females with a history of an ED and 105 age-matched female controls who completed questionnaires, interviews, and weight/height measurements at baseline and ~1-year follow-up. To examine different comprehensive operationalizations of recovery, we considered two approaches to assessing each of the following domains of recovery: physical (BMI >/= 18.5 kg/m(2); BMI >/= 19 kg/m(2)), behavioral (no binge eating, purging, or fasting in the past 3 months; none of these ED behaviors in the past 6 months), and cognitive (all four EDE-Q subscale scores within 1 SD of age- and gender-matched norms; Global EDE-Q scores within 1 SD of norms). Allowing for all possible combinations across these domains yielded eight operationalizations of comprehensive ED recovery to test. RESULTS: Results showed that operationalizations were more similar than different, with high rates of stability in recovery (77%-86%) and low relapse rates (7%-15%) over time. DISCUSSION: Based on the holistic consideration of the patterns of findings, we propose using BMI >/= 18.5 or 19 kg/m(2) (physical recovery), no binge eating, purging, or fasting over the past 3 months (behavioral recovery), and all four EDE-Q subscale scores within 1 SD of age- and gender-matched norms (cognitive recovery) as a standardized operationalization of recovery for research purposes. CI - (c) 2025 Wiley Periodicals LLC. FAU - Bardone-Cone, Anna M AU - Bardone-Cone AM AUID- ORCID: 0000-0002-1855-6328 AD - Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Watson, Hunna J AU - Watson HJ AUID- ORCID: 0000-0001-8405-381X AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - School of Psychology, Curtin University, Perth, Western Australia, Australia. AD - School of Paediatrics and Child Health, The University of Western Australia, Perth, Western Australia, Australia. FAU - Walsh, Emily C AU - Walsh EC AD - Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Wash, Lauren K AU - Wash LK AUID- ORCID: 0000-0002-9279-6602 AD - Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Wallace, Lauren R AU - Wallace LR AD - Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Zucker, Nancy AU - Zucker N AUID- ORCID: 0000-0003-2278-5008 AD - Division of Child and Family Mental Health and Developmental Neuroscience, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA. AD - Department of Psychology and Neuroscience, Duke University, Durham, North Carolina, USA. FAU - Bulik, Cynthia M AU - Bulik CM AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. LA - eng GR - R01MH095860/MH/NIMH NIH HHS/United States PT - Comparative Study PT - Journal Article DEP - 20251022 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM MH - Humans MH - Female MH - Adult MH - *Feeding and Eating Disorders/psychology/therapy MH - *Cognition MH - Young Adult MH - Case-Control Studies MH - Adolescent MH - Surveys and Questionnaires OTO - NOTNLM OT - behavioral OT - cognitive OT - eating disorder OT - physical OT - recovery EDAT- 2025/10/22 12:31 MHDA- 2026/02/09 06:30 CRDT- 2025/10/22 06:04 PHST- 2025/08/24 00:00 [revised] PHST- 2025/06/20 00:00 [received] PHST- 2025/09/14 00:00 [accepted] PHST- 2026/02/09 06:30 [medline] PHST- 2025/10/22 12:31 [pubmed] PHST- 2025/10/22 06:04 [entrez] AID - 10.1002/eat.24559 [doi] PST - ppublish SO - Int J Eat Disord. 2026 Feb;59(2):236-248. doi: 10.1002/eat.24559. Epub 2025 Oct 22. PMID- 41122853 OWN - NLM STAT- MEDLINE DCOM- 20260209 LR - 20261023 IS - 1098-108X (Electronic) IS - 0276-3478 (Print) IS - 0276-3478 (Linking) VI - 59 IP - 2 DP - 2026 Feb TI - Clinical Significance and Distinctiveness of DSM-5 Other Specified Feeding or Eating Disorder-Bulimia Nervosa of Low Frequency and/or Limited Duration in Women. PG - 311-322 LID - 10.1002/eat.24580 [doi] AB - BACKGROUND: Formation of Diagnostic and Statistical Manual of Mental Disorders (DSM) subcommittees combined with recently approved coding designations for bulimia nervosa (BN) in partial remission highlights the need to examine the validity of the threshold that distinguishes BN from other specified feeding or eating disorders (OSFED) BN of low frequency and/or limited duration (OSFED-BN). METHODS: Women (N = 344) who met DSM-5 criteria for BN (n = 153) or OSFED-BN (n = 118) or had no lifetime eating disorder symptoms (n = 78) completed assessments of height, weight, weight history, percent body fat, structured clinical interviews for DSM-5 disorders, suicidality, trauma, and treatment histories, and self-report questionnaires covering a range of validators related to eating disorders, psychological traits, and general psychopathology. Comparisons across groups tested the validity of OSFED-BN and whether prior history of DSM-5 BN impacted evidence of its clinical significance and distinctiveness. RESULTS: Lower frequency of binge eating was the primary reason for diagnosis of OSFED-BN vs. BN; more than 80% of those with OSFED-BN met or exceeded frequency and duration criteria for inappropriate compensatory behaviors. The current DSM-5 threshold distinguishing BN from its OSFED variant or from BN in partial remission produced few differences relative to several large differences observed for comparisons of these diagnostic groups and non-eating disorder controls. DISCUSSION: Despite being associated with distinct DSM-5 diagnostic codes, BN, BN in partial remission, and OSFED-BN appear to represent a single condition that may, at most, capture some dimensional differences in severity. Findings support lowering the current minimum frequency thresholds for diagnosing BN. CI - (c) 2025 Wiley Periodicals LLC. FAU - Keel, Pamela K AU - Keel PK AUID- ORCID: 0000-0001-6542-5147 AD - Department of Psychology, Florida State University, Tallahassee, Florida, USA. FAU - Bodell, Lindsay P AU - Bodell LP AUID- ORCID: 0000-0001-8346-7762 AD - Department of Psychology, Western University, London, Canada. FAU - Appelbaum, Jonathan AU - Appelbaum J AUID- ORCID: 0000-0002-4604-7491 AD - College of Medicine, Florida State University, Tallahassee, Florida, USA. FAU - Williams, Diana L AU - Williams DL AUID- ORCID: 0000-0002-3548-7440 AD - Kravis Department of Integrated Sciences, Claremont McKenna College, Claremont, California, USA. LA - eng GR - R01 MH111263/MH/NIMH NIH HHS/United States GR - US Department of Education Higher Education Emergency Relief Fund (HEERF)/ GR - R01MH111263/MH/NIMH NIH HHS/United States GR - R01MH111263/MH/NIMH NIH HHS/United States PT - Journal Article DEP - 20251022 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM MH - Humans MH - Female MH - *Diagnostic and Statistical Manual of Mental Disorders MH - Adult MH - *Bulimia Nervosa/diagnosis/psychology/classification MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Young Adult MH - Adolescent MH - Middle Aged MH - Clinical Relevance PMC - PMC12577754 MID - NIHMS2119763 OTO - NOTNLM OT - DSM-5 OT - binge eating OT - classification OT - inappropriate compensatory behavior OT - nosology OT - validation COIS- Conflict of interest disclosure: Dr. Appelbaum serves on the Advisory Board of EMD Serono on HIV related research. EDAT- 2025/10/22 06:33 MHDA- 2026/02/09 06:30 PMCR- 2026/10/22 CRDT- 2025/10/22 05:04 PHST- 2025/10/06 00:00 [revised] PHST- 2025/08/21 00:00 [received] PHST- 2025/10/10 00:00 [accepted] PHST- 2026/02/09 06:30 [medline] PHST- 2025/10/22 06:33 [pubmed] PHST- 2025/10/22 05:04 [entrez] PHST- 2026/10/22 00:00 [pmc-release] AID - 10.1002/eat.24580 [doi] PST - ppublish SO - Int J Eat Disord. 2026 Feb;59(2):311-322. doi: 10.1002/eat.24580. Epub 2025 Oct 22. PMID- 41121352 OWN - NLM STAT- MEDLINE DCOM- 20251022 LR - 20251025 IS - 1479-5868 (Electronic) IS - 1479-5868 (Linking) VI - 22 IP - 1 DP - 2025 Oct 21 TI - Development of the Canadian food intake screener for adolescents based on Canada's Food Guide 2019 healthy eating recommendations. PG - 129 LID - 10.1186/s12966-025-01837-1 [doi] LID - 129 AB - BACKGROUND: Assessing adolescents' dietary intakes in relation to Canada's Food Guide 2019 (CFG-2019) recommendations on healthy food choices is a critical component to public health surveillance efforts. The study aimed to develop a brief self-administered screener to assess food intake based on CFG-2019 food choices recommendations among English- and French-speaking adolescents aged 10-17 years living in Canada. METHODS: The development and assessment of the content validity of the tool was undertaken in collaboration with Health Canada advisors and informed by external content experts, including nutrition researchers and practitioners. Following a rapid review of screeners used among children aged 6-17 years, an initial draft was developed, and content validity was assessed by an expert panel with expertise in public health nutrition and questionnaire validation (English n = 13, French n = 7). Two rounds of cognitive interviews were then conducted with adolescents (English n = 15, French n = 14) to assess comprehension and further refine the screener items. Cognitive testing using a direct probing approach was conducted iteratively in two phases to assess understanding of questions and incorporate feedback from adolescents to improve the clarity and wording of the items at each phase. RESULTS: Following the expert panel and iterative discussions with Health Canada advisors, four items were removed from the initial 14-item screener as these items were deemed not sufficiently reflective of the CFG recommendations and one item asking about water intake was tested. Cognitive testing revealed that the items were well understood overall, and feedback at each interview round enabled additional refinements to improve comprehension. The resulting screener includes 10 items designed to rapidly assess food intake based on CFG-2019 recommendations on healthy food choices for adolescents aged 10 to 17 years. CONCLUSIONS: The Canadian Food Intake Screener for Adolescents/Questionnaire court canadien sur les apports alimentaires des adolescents is designed to rapidly assess dietary intake over the past week among children aged 10 to 17 years. Before it can be used for research and population-level nutrition surveillance, further research is needed to develop a scoring system and evaluate the screener's construct validity and reliability. CI - (c) 2025. The Author(s). FAU - Tugault-Lafleur, Claire AU - Tugault-Lafleur C AD - School of Nutrition, Faculty of Health Sciences, University of Ottawa, 200 Lees Ave, Ottawa, ON, K1S 5S9, Canada. ctugault@uottawa.ca. FAU - Desgreniers, Virginie AU - Desgreniers V AD - School of Nutrition, Faculty of Health Sciences, University of Ottawa, 200 Lees Ave, Ottawa, ON, K1S 5S9, Canada. FAU - Bessette, Genevieve AU - Bessette G AD - School of Nutrition, Faculty of Health Sciences, University of Ottawa, 200 Lees Ave, Ottawa, ON, K1S 5S9, Canada. FAU - Kazzi, Rita Al AU - Kazzi RA AD - School of Nutrition, Faculty of Health Sciences, University of Ottawa, 200 Lees Ave, Ottawa, ON, K1S 5S9, Canada. FAU - Jacob, Raphaelle AU - Jacob R AD - Department of Family Relations and Applied Nutrition, University of Guelph, Guelph, ON, Canada. FAU - Hernandez, Kimberley AU - Hernandez K AD - Health Canada, Government of Canada, Ottawa, ON, Canada. FAU - St-Pierre, Sylvie AU - St-Pierre S AD - Health Canada, Government of Canada, Ottawa, ON, Canada. FAU - Haines, Jess AU - Haines J AD - Department of Family Relations and Applied Nutrition, University of Guelph, Guelph, ON, Canada. LA - eng GR - MFE-176530/CAPMC/CIHR/Canada PT - Journal Article DEP - 20251021 PL - England TA - Int J Behav Nutr Phys Act JT - The international journal of behavioral nutrition and physical activity JID - 101217089 SB - IM MH - Humans MH - Adolescent MH - Canada MH - Child MH - Female MH - Male MH - *Diet, Healthy MH - *Nutrition Policy MH - Surveys and Questionnaires/standards MH - Reproducibility of Results PMC - PMC12539109 OTO - NOTNLM OT - Adolescent OT - Canada's food guide OT - Children OT - Cognitive interviews OT - Content validity OT - Questionnaire development COIS- Declarations. Ethics approval and consent to participate: Ethics approval was obtained at the University of Ottawa (H-11-23-9832), the University of Guelph (certificate number 21-02-010) and Health Canada's Research Ethics Board (certificate number REB 2023-036 H). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/10/22 06:34 MHDA- 2025/10/22 06:35 PMCR- 2025/10/21 CRDT- 2025/10/22 00:20 PHST- 2025/07/07 00:00 [received] PHST- 2025/09/20 00:00 [accepted] PHST- 2025/10/22 06:35 [medline] PHST- 2025/10/22 06:34 [pubmed] PHST- 2025/10/22 00:20 [entrez] PHST- 2025/10/21 00:00 [pmc-release] AID - 10.1186/s12966-025-01837-1 [pii] AID - 1837 [pii] AID - 10.1186/s12966-025-01837-1 [doi] PST - epublish SO - Int J Behav Nutr Phys Act. 2025 Oct 21;22(1):129. doi: 10.1186/s12966-025-01837-1. PMID- 41120727 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20261008 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) VI - 99 IP - 7 DP - 2026 Jun TI - Maternal dietary phylloquinone intake (vitamin K1) and early childhood neurodevelopment. PG - 2522-2530 LID - 10.1038/s41390-025-04543-7 [doi] AB - BACKGROUND: Maternal nutrition is a crucial modifiable factor with phylloquinone being involved in processes related to optimal brain development. This study aimed to evaluate the associations between maternal phylloquinone intake during pregnancy and early neurodevelopment in children. METHODS: This study included 1080 pregnant women and their offspring from the Barcelona Life Study Cohort (BiSC). Maternal phylloquinone intake during pregnancy was estimated using a validated semiquantitative 114-item food frequency questionnaire. The Developmental Profile 3 (DP-3) and the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) were administered during early childhood. Statistical analysis was conducted using multivariable linear mixed-effects models and linear regression models. RESULTS: Higher maternal dietary phylloquinone intake during pregnancy was associated with increased global developmental index scores (beta [95% CI]: 0.88 [0.10, 1.66]) and better cognitive (beta [95% CI]: 0.87 [0.14, 1.60]) and physical development (beta [95% CI]: 0.72 [0.02, 1.42]), based on DP-3 scores. Similarly, motor development assessed through BSID-III scores was consistently higher in offspring of mothers within the highest phylloquinone intake (beta [95% CI]: 1.69 [0.008, 3.38]). CONCLUSION: Higher dietary phylloquinone intake during pregnancy was associated with improved offspring neurodevelopment, emphasizing the need for tailored recommendations during pregnancy to support optimal brain development. IMPACT: Prenatal maternal nutrition has been recognized as a critical modifiable factor influencing optimal brain development. No previous studies have examined the impact of maternal phylloquinone intake during pregnancy on neurodevelopment. Higher maternal dietary intake of phylloquinone was associated with higher global developmental index scores, as well as improved cognitive and physical development in early childhood. These findings emphasize the need for tailored vitamin K recommendations during pregnancy to support optimal brain development in offspring. CI - (c) 2025. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - Mateu-Fabregat, Javier AU - Mateu-Fabregat J AD - Nutrition and Metabolic Health Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili (URV), Reus, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. AD - Center of Environmental, Food and Toxicological Technology (TecnATox), Universitat Rovira i Virgili (URV), Reus, Spain. FAU - Panisello, Laura AU - Panisello L AD - Nutrition and Metabolic Health Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili (URV), Reus, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. AD - Center of Environmental, Food and Toxicological Technology (TecnATox), Universitat Rovira i Virgili (URV), Reus, Spain. FAU - Novau-Ferre, Nil AU - Novau-Ferre N AD - Nutrition and Metabolic Health Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili (URV), Reus, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. AD - Center of Environmental, Food and Toxicological Technology (TecnATox), Universitat Rovira i Virgili (URV), Reus, Spain. FAU - Pinar-Marti, Ariadna AU - Pinar-Marti A AD - Clinical and Epidemiological Neuroscience (NeuroĖpia), Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. AD - ISGlobal, Barcelona, Spain. AD - Universitat Pompeu Fabra (UPF), Barcelona, Spain. AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Carlos III Health Institute, Madrid, Spain. FAU - Jimenez-Arenas, Pol AU - Jimenez-Arenas P AD - ISGlobal, Barcelona, Spain. AD - Universitat Pompeu Fabra (UPF), Barcelona, Spain. AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Carlos III Health Institute, Madrid, Spain. FAU - Ferrer, Muriel AU - Ferrer M AD - ISGlobal, Barcelona, Spain. AD - Universitat Pompeu Fabra (UPF), Barcelona, Spain. AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Carlos III Health Institute, Madrid, Spain. FAU - Rivas, Ioar AU - Rivas I AD - ISGlobal, Barcelona, Spain. AD - Universitat Pompeu Fabra (UPF), Barcelona, Spain. AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Carlos III Health Institute, Madrid, Spain. AD - Institute of Environmental Assessment and Water Research (IDAEA), Spanish National Research Council (CSIC), Barcelona, Spain. FAU - Llurba, Elisa AU - Llurba E AD - Department of Obstetrics and Gynaecology. Institut d'Investigacio Biomedica Sant Pau-IIB Sant Pau. Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. FAU - Lassale, Camille AU - Lassale C AD - ISGlobal, Barcelona, Spain. AD - Universitat Pompeu Fabra (UPF), Barcelona, Spain. AD - CIBER Physiology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, Madrid, Spain. FAU - Gomez-Roig, Maria Dolores AU - Gomez-Roig MD AD - BCNatal. Barcelona Center for Maternal Fetal and Neonatal Medicine (Hospital Sant Joan de Deu and Hospital Clinic), University of Barcelona, Barcelona, Spain. AD - Institut de Recerca Sant Joan de Deu, Esplugues de Llobregat, Barcelona, Spain. AD - Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS), RD21/0012/0003, Instituto de Salud Carlos III, Madrid, Spain. FAU - Vioque, Jesus AU - Vioque J AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Carlos III Health Institute, Madrid, Spain. AD - Universidad Miguel Hernandez, Instituto de Investigacion Sanitaria y Biomedica de Alicante (UMH-ISABIAL), Alicante, Spain. FAU - Gonzalez-Palacios, Sandra AU - Gonzalez-Palacios S AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Carlos III Health Institute, Madrid, Spain. AD - Universidad Miguel Hernandez, Instituto de Investigacion Sanitaria y Biomedica de Alicante (UMH-ISABIAL), Alicante, Spain. FAU - Contreras-Rodriguez, Oren AU - Contreras-Rodriguez O AD - Department of Psychiatry and Forensic Medicine, Universitat Autonoma de Barcelona, Bellaterra, Spain. AD - CIBER Mental Health (CIBERSAM), Carlos III Health Institute, Madrid, Spain. FAU - Arija, Victoria AU - Arija V AD - Nutrition and Mental Health Research Group (NUTRISAM), Universitat Rovira i Virgili (URV), Tarragona, Spain. FAU - Foraster, Maria AU - Foraster M AD - PHAGEX Research Group, Blanquerna School of Health Science, Universitat Ramon Llull (URL), Barcelona, Spain. FAU - Gascon, Mireia AU - Gascon M AD - ISGlobal, Barcelona, Spain. AD - Universitat Pompeu Fabra (UPF), Barcelona, Spain. AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Carlos III Health Institute, Madrid, Spain. AD - Unitat de Suport a la Recerca de la Catalunya Central, Fundacio Institut Universitari per a la Recerca a l'Atencio Primaria de Salut Jordi Gol i Gurina (IDIAPJGol), Manresa, Spain. FAU - Dadvand, Payam AU - Dadvand P AD - ISGlobal, Barcelona, Spain. AD - Universitat Pompeu Fabra (UPF), Barcelona, Spain. AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Carlos III Health Institute, Madrid, Spain. FAU - Sunyer, Jordi AU - Sunyer J AD - ISGlobal, Barcelona, Spain. AD - Universitat Pompeu Fabra (UPF), Barcelona, Spain. AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Carlos III Health Institute, Madrid, Spain. FAU - Julvez, Jordi AU - Julvez J AD - Clinical and Epidemiological Neuroscience (NeuroĖpia), Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. jordi.julvez@iispv.cat. AD - ISGlobal, Barcelona, Spain. jordi.julvez@iispv.cat. AD - Universitat Pompeu Fabra (UPF), Barcelona, Spain. jordi.julvez@iispv.cat. AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Carlos III Health Institute, Madrid, Spain. jordi.julvez@iispv.cat. FAU - Bullo, Monica AU - Bullo M AD - Nutrition and Metabolic Health Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili (URV), Reus, Spain. monica.bullo@urv.cat. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. monica.bullo@urv.cat. AD - Center of Environmental, Food and Toxicological Technology (TecnATox), Universitat Rovira i Virgili (URV), Reus, Spain. monica.bullo@urv.cat. AD - CIBER Physiology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, Madrid, Spain. monica.bullo@urv.cat. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251021 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 RN - 84-80-0 (Vitamin K 1) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Neurodevelopment MH - Infant MH - *Vitamin K 1/administration & dosage MH - *Child Development MH - Adult MH - *Maternal Nutritional Physiological Phenomena MH - Child, Preschool MH - Male MH - *Diet MH - Cognition MH - Spain COIS- Competing interests: The authors declare no competing interests. Informed consent: All participants provided written informed consent to participate. EDAT- 2025/10/22 02:35 MHDA- 2026/08/19 14:48 CRDT- 2025/10/21 23:51 PHST- 2025/07/17 00:00 [received] PHST- 2025/09/15 00:00 [accepted] PHST- 2025/09/05 00:00 [revised] PHST- 2026/08/19 14:48 [medline] PHST- 2025/10/22 02:35 [pubmed] PHST- 2025/10/21 23:51 [entrez] AID - 10.1038/s41390-025-04543-7 [pii] AID - 10.1038/s41390-025-04543-7 [doi] PST - ppublish SO - Pediatr Res. 2026 Jun;99(7):2522-2530. doi: 10.1038/s41390-025-04543-7. Epub 2025 Oct 21. PMID- 41118496 OWN - NLM STAT- MEDLINE DCOM- 20260409 LR - 20260811 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 9 DP - 2025 Oct 21 TI - Transition From a Paper Diary to an Electronic Diary by Parents of Preschool Children With Food Allergies: Pilot Study. PG - e73400 LID - 10.2196/73400 [doi] LID - e73400 AB - BACKGROUND: Food allergies (FAs) can be life-threatening and represent a significant public health concern. The reported prevalence of FA in Japan is 7.6% in 1-year-olds, 6.7% in 2-year-olds, and 4.9% in 3-year-olds. In addition, avoiding allergenic foods, prompt identification, and response are required when symptoms appear. A food diary is a tool for daily dietary management, recording of symptoms, and communication between families of children with FA and health care providers. Conventionally, paper diaries (P-diaries) have been used. Recent technological advancements and the extensive use of smartphones have prompted the development of numerous electronic diaries (E-diaries). However, few studies have evaluated the effectiveness of E-diaries in Japan. OBJECTIVE: This study aimed to assess the experiences of parents of preschool children with FA as they transitioned from P-diaries to E-diaries. METHODS: For 6 months commencing in October 2020, during the period of movement restrictions due to the COVID-19 pandemic, we recruited parents of preschool children diagnosed with FAs by an allergist at a single general hospital. This pilot study used a single-group pretest-posttest design to evaluate the feasibility of using an E-diary. To assess parents' views on transitioning to E-diaries from P-diaries, data were collected using semistructured interviews conducted after 6 months of E-diary use. RESULTS: Five parents took part in the study. The problems with P-diaries and the effects and outcomes of E-diaries from the perspective of parents of preschool children with FA were categorized into 52 codes, which were grouped into 19 subcategories and 6 categories. Parents of preschool children with FA reported the following issues: I. difficulties with using a P-diary; II. stress related to sharing information with doctors; III. difficulties in making disease management habitual as issues with P-diary use; IV. ease of using the E-diary as an effect of the transition; V. more efficient sharing of information with doctors; and VI. improved adherence as outcomes of E-diary use. CONCLUSIONS: E-diaries may resolve various issues associated with P-diaries and may be useful tools for communication between parents and physicians regarding disease management. Since the number of participants was small (ie, 5) and the study was conducted at a single facility, theoretical saturation was not reached. In the future, it will be necessary to increase the number of participants to validate these findings. CI - (c) Yoriko Kato. Originally published in JMIR Formative Research (https://formative.jmir.org). FAU - Kato, Yoriko AU - Kato Y AUID- ORCID: 0000-0002-1204-3564 AD - School of Nursing, Sapporo City University, North 11 West 13, Chuo-ku, Sapporo, Hokkaido, 060-0011, Japan, 81 (11) 7262500. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251021 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM EIN - doi: 10.2196/92855 MH - *Diet Records MH - *Diaries as Topic MH - *Food Hypersensitivity/diagnosis/epidemiology/therapy MH - Pilot Projects MH - Prevalence MH - Japan/epidemiology MH - *Smartphone MH - Feasibility Studies MH - *Parents MH - Communication MH - Non-Randomized Controlled Trials as Topic MH - Humans MH - Male MH - Female MH - Child, Preschool MH - Child MH - Adult PMC - PMC12539650 OTO - NOTNLM OT - electronic diary OT - food allergies OT - paper diary OT - parents OT - preschool children COIS- Conflicts of Interest: None declared. EDAT- 2025/10/21 18:30 MHDA- 2025/10/21 18:31 PMCR- 2025/10/21 CRDT- 2025/10/21 14:23 PHST- 2025/03/11 00:00 [received] PHST- 2025/08/14 00:00 [revised] PHST- 2025/08/17 00:00 [accepted] PHST- 2025/10/21 18:31 [medline] PHST- 2025/10/21 18:30 [pubmed] PHST- 2025/10/21 14:23 [entrez] PHST- 2025/10/21 00:00 [pmc-release] AID - v9i1e73400 [pii] AID - 73400 [pii] AID - 10.2196/73400 [doi] PST - epublish SO - JMIR Form Res. 2025 Oct 21;9:e73400. doi: 10.2196/73400. PMID- 41118364 OWN - NLM STAT- MEDLINE DCOM- 20251021 LR - 20251024 IS - 1549-1676 (Electronic) IS - 1549-1277 (Print) IS - 1549-1277 (Linking) VI - 22 IP - 10 DP - 2025 Oct TI - Impact of excessive social media use on adolescent depression and its consequences in France: An individual-based microsimulation model. PG - e1004737 LID - 10.1371/journal.pmed.1004737 [doi] LID - e1004737 AB - BACKGROUND: Social media (SM) platforms have become increasingly prevalent in adolescents' lives, and concerns have arisen regarding their potential contribution to depression. This study examined whether excessive SM use contributes to rising adolescent depression rates and evaluated potential mitigation strategies. METHODS AND FINDINGS: We developed an individual-based microsimulation model of 18.6 million French adolescents born 1990-2012, tracking depression outcomes from 2000-2022 (analyses conducted August 2024-July 2025). The model incorporated 95 parameters, including demographics, SM use patterns, and established depression risk factors (childhood adversities, chronic physical conditions, physical inactivity, obesity, substance use). The main outcome was cumulative depression cases, and secondary outcomes were suicide deaths, health-adjusted life expectancy (HALE) loss, and associated costs. The model was well-calibrated and validated adequately against US-specific data. It showed that excessive SM use likely played an important role in the recent increase in rates of adolescent depression. Among French adolescents, simulations indicated that excessive SM use was associated with an additional cumulative lifetime 590,000 depression cases (95%CI [400,000, 760,000]), 799 suicide deaths (95%CI [547, 1,028]), 137,000 (95%CI [94,000, 176,000]) HALE loss years, and 3.94 (95%CI [2.70, 5.07]) billion euros, compared to scenarios without SM platforms. Key limitations are that microsimulation modeling cannot establish causality from observational data and the reliance on duration-based exposure measures without capturing content type or engagement quality. CONCLUSIONS: In this study, we estimated that limiting SM use to 1 h per day for all adolescents, replacing 30 min of SM use with 30 min of physical activity, or stopping its use for adolescents most at-risk for depression, would be associated with a reduction in cumulative lifetime prevalence of depression by 14.7%, 12.9%, and 12.0%, respectively, and diminished associated costs. Targeted SM interventions could potentially reduce adolescent depression burden, though real-world implementation and effectiveness require validation. CI - Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. FAU - Hoertel, Nicolas AU - Hoertel N AUID- ORCID: 0000-0002-7890-1349 AD - AP-HP.Centre, DMU Psychiatrie et Addictologie, Corentin Celton Hospital, Issy-les-Moulineaux, France. AD - Universite Paris Cite, Faculte de Sante, UFR de Medecine, Paris, France. AD - INSERM UMR_1266, Institut de Psychiatrie et Neuroscience de Paris, Paris, France. FAU - Olfson, Mark AU - Olfson M AD - New York State Psychiatric Institute, Columbia University Irving Medical Center, New York, New York, United States of America. FAU - Blanco, Carlos AU - Blanco C AD - Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, Bethesda, Maryland, United States of America. FAU - Biscond, Margot AU - Biscond M AD - Public Health Expertise, Paris, France. FAU - Limosin, Frederic AU - Limosin F AD - AP-HP.Centre, DMU Psychiatrie et Addictologie, Corentin Celton Hospital, Issy-les-Moulineaux, France. AD - Universite Paris Cite, Faculte de Sante, UFR de Medecine, Paris, France. AD - INSERM UMR_1266, Institut de Psychiatrie et Neuroscience de Paris, Paris, France. FAU - Sanchez-Rico, Marina AU - Sanchez-Rico M AUID- ORCID: 0000-0002-1121-8641 AD - AP-HP.Centre, DMU Psychiatrie et Addictologie, Corentin Celton Hospital, Issy-les-Moulineaux, France. FAU - Blachier, Martin AU - Blachier M AD - Public Health Expertise, Paris, France. FAU - Leleu, Henri AU - Leleu H AUID- ORCID: 0000-0003-4930-6767 AD - Public Health Expertise, Paris, France. LA - eng PT - Journal Article DEP - 20251021 PL - United States TA - PLoS Med JT - PLoS medicine JID - 101231360 SB - IM MH - Humans MH - Adolescent MH - France/epidemiology MH - Female MH - Male MH - *Depression/epidemiology/psychology/etiology MH - *Social Media/statistics & numerical data MH - Risk Factors MH - Suicide/statistics & numerical data MH - *Adolescent Behavior/psychology MH - Computer Simulation PMC - PMC12539716 COIS- The authors have declared that no competing interests exist. EDAT- 2025/10/21 18:29 MHDA- 2025/10/21 18:30 PMCR- 2025/10/21 CRDT- 2025/10/21 13:33 PHST- 2024/11/22 00:00 [received] PHST- 2025/08/29 00:00 [accepted] PHST- 2025/10/21 18:30 [medline] PHST- 2025/10/21 18:29 [pubmed] PHST- 2025/10/21 13:33 [entrez] PHST- 2025/10/21 00:00 [pmc-release] AID - PMEDICINE-D-24-03990 [pii] AID - 10.1371/journal.pmed.1004737 [doi] PST - epublish SO - PLoS Med. 2025 Oct 21;22(10):e1004737. doi: 10.1371/journal.pmed.1004737. eCollection 2025 Oct. PMID- 41117840 OWN - NLM STAT- MEDLINE DCOM- 20251021 LR - 20261009 IS - 1437-2320 (Electronic) IS - 0344-5607 (Linking) VI - 48 IP - 1 DP - 2025 Oct 21 TI - Development and validation of a multi-parameter nomogram for venous thromboembolism in patients undergoing surgery for brain tumors: a retrospective analysis. PG - 727 LID - 10.1007/s10143-025-03887-2 [doi] AB - Venous thromboembolism (VTE) is a serious complication in patients undergoing brain tumor surgery, particularly those requiring neurological intensive care unit (NICU) monitoring. Risk factors for VTE vary among tumor types, and effective early warning tools remain scarce. This study aimed to develop a nomogram-based clinical prediction model to identify independent risk factors for postoperative VTE in brain tumor patients. A total of 400 NICU patients (aged 18-82 years; mean age 52.5 +/- 15.6 years; 46.5% male) from January 2018 to July 2023 who underwent brain tumor surgery were included, among whom 96 developed postoperative VTE (24%). Univariate, LASSO regression, and multivariate logistic regression analyses identified independent predictors, and a nomogram prediction model was constructed. The C-index and calibration curve evaluated the model's discriminative ability and stability, while decision curve analysis assessed its clinical utility. The Linear Support Vector Machine (LSVM) method validated the model's robustness. Seven independent predictors were identified and incorporated into a nomogram: elevated preoperative D-dimer levels, elevated HbA1c levels post-admission, longer surgery duration, increased TT4 levels upon admission, increased BMI, older age and hyperlipidemia history. These factors were incorporated into a nomogram risk prediction model with an AUC of 0.937 using multivariate logistic regression. The calibration curve verified the model's stability, the C-index demonstrated strong discriminative ability, and decision curve analysis confirmed its clinical value. A linear support vector machine (LSVM) was further used to validate the predictive efficacy of the same set of variables achieved an overall accuracy of 85%. The nomogram integrates multiple clinical parameters to enhance the prediction and identification of VTE risk following brain tumor surgery. It demonstrated excellent discriminative ability, stability, and clinical applicability. CI - (c) 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Wang, Mei-Hua AU - Wang MH AD - Department of Neurosurgery & Neurocritical care, Huashan Hospital Fudan University, Shanghai, 200040, China. AD - Department of Neurosurgery; National Center for Neurological Disorders; Neurosurgical Institute of Fudan University; Shanghai Clinical Medical Center of Neurosurgery; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, China. FAU - Zhang, Jun AU - Zhang J AD - Department of Neurosurgery & Neurocritical care, Huashan Hospital Fudan University, Shanghai, 200040, China. AD - Department of Neurosurgery; National Center for Neurological Disorders; Neurosurgical Institute of Fudan University; Shanghai Clinical Medical Center of Neurosurgery; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, China. FAU - Yang, Lei AU - Yang L AD - Department of Neurosurgery & Neurocritical care, Huashan Hospital Fudan University, Shanghai, 200040, China. AD - Department of Neurosurgery; National Center for Neurological Disorders; Neurosurgical Institute of Fudan University; Shanghai Clinical Medical Center of Neurosurgery; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, China. FAU - Zhao, Jianlan AU - Zhao J AD - Department of Neurosurgery & Neurocritical care, Huashan Hospital Fudan University, Shanghai, 200040, China. FAU - Yao, Haijun AU - Yao H AD - Department of Neurosurgery & Neurocritical care, Huashan Hospital Fudan University, Shanghai, 200040, China. AD - Department of Neurosurgery; National Center for Neurological Disorders; Neurosurgical Institute of Fudan University; Shanghai Clinical Medical Center of Neurosurgery; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, China. FAU - Xu, Hongzhi AU - Xu H AD - Department of Neurosurgery; National Center for Neurological Disorders; Neurosurgical Institute of Fudan University; Shanghai Clinical Medical Center of Neurosurgery; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, China. FAU - Wu, Gang AU - Wu G AD - Department of Neurosurgery & Neurocritical care, Huashan Hospital Fudan University, Shanghai, 200040, China. woogangng@sina.com. AD - Department of Neurosurgery; National Center for Neurological Disorders; Neurosurgical Institute of Fudan University; Shanghai Clinical Medical Center of Neurosurgery; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, China. woogangng@sina.com. FAU - Hu, Jin AU - Hu J AD - Department of Neurosurgery & Neurocritical care, Huashan Hospital Fudan University, Shanghai, 200040, China. hujin@fudan.edu.cn. AD - Department of Neurosurgery; National Center for Neurological Disorders; Neurosurgical Institute of Fudan University; Shanghai Clinical Medical Center of Neurosurgery; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, China. hujin@fudan.edu.cn. LA - eng PT - Journal Article PT - Validation Study DEP - 20251021 PL - Germany TA - Neurosurg Rev JT - Neurosurgical review JID - 7908181 SB - IM MH - Humans MH - *Nomograms MH - Middle Aged MH - Male MH - *Venous Thromboembolism/etiology/diagnosis MH - Female MH - *Brain Neoplasms/surgery MH - Adult MH - Aged MH - Retrospective Studies MH - *Postoperative Complications/diagnosis/etiology/epidemiology MH - Adolescent MH - Aged, 80 and over MH - Risk Factors MH - Young Adult MH - *Neurosurgical Procedures/adverse effects OTO - NOTNLM OT - Brain tumor OT - Neurocritical care OT - Nomogram prediction model OT - Risk factors OT - Venous thromboembolism COIS- Declarations. Clinical trial number: not applicable. Competing interests: The authors declare no competing interests. Ethical approval: This study was approved by the Clinical Ethics Committee of Huashan Hospital, Fudan University. Consent: The patients' written consent was not required because this study is a retrospective observational cohort study. Source of funding: This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. Conflicts of interest disclosure: The authors of this work have nothing to disclose. Guarantor: Authors Meihua Wang and Jin Hu take full responsibility for the work and conduct of the study, had access to the data, and controlled the decision to publish. Provenance and peer review: Not commissioned, externally peer-reviewed. EDAT- 2025/10/21 12:35 MHDA- 2025/10/21 12:36 CRDT- 2025/10/21 11:03 PHST- 2024/12/30 00:00 [received] PHST- 2025/10/05 00:00 [accepted] PHST- 2025/09/21 00:00 [revised] PHST- 2025/10/21 12:36 [medline] PHST- 2025/10/21 12:35 [pubmed] PHST- 2025/10/21 11:03 [entrez] AID - 10.1007/s10143-025-03887-2 [pii] AID - 10.1007/s10143-025-03887-2 [doi] PST - epublish SO - Neurosurg Rev. 2025 Oct 21;48(1):727. doi: 10.1007/s10143-025-03887-2. PMID- 41115654 OWN - NLM STAT- MEDLINE DCOM- 20251201 LR - 20251201 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 70 DP - 2025 Dec TI - Body composition and phase angle as prognostic factors in adults with acute lymphoblastic leukemia. PG - 420-426 LID - S2405-4577(25)02964-X [pii] LID - 10.1016/j.clnesp.2025.10.006 [doi] AB - INTRODUCTION: The prognostic role of body composition and phase angle (PhA) in adult patients with acute lymphoblastic leukemia (ALL) remains unclear. This study evaluates the impact of body composition parameters and PhA on overall survival (OS) and disease-free survival (DFS) in ALL patients receiving intensive chemotherapy. METHODS: We conducted a retrospective analysis of 81 adult ALL patients. Baseline body composition was assessed at ALL diagnosis and before therapy using bioelectrical impedance analysis (BIA), including body fat mass (BFM), fat mass index (FMI), fat-free mass (FFM), fat free mass index (FFMI), and PhA. Kaplan-Meier curves and log-rank tests were employed to compare survival outcomes across body composition and PhA categories. Cox regression was used for multivariate analysis to confirm findings. RESULTS: The median age at diagnosis was 25 years (range: 16-67), with 56.8 % being male and 91.3 % having B-cell ALL. A significant association was observed between lower PhA (/=25 showed a trend toward worse OS but was not statistically significant. Multivariate Cox regression confirmed that PhA /=5 food groups) had a sensitivity of 22.4% and a specificity of 91.4%, denoting slight agreement. The optimal cutoff point for MDD-C was found to be >/= 3 food groups, with a sensitivity of 85.5% and a specificity of 62.9%. This optimal cutoff adjustment improved the agreement between the MDD-C indicator and micronutrient adequacy to a moderate level. CONCLUSIONS: The MDD-C had a moderate positive correlation and a fair predictive ability with the MAR to accurately predict micronutrient intake adequacy at the optimal cutoff, despite poor sensitivity and high specificity at the standard cutoff. Countries need to adapt MDD-C cutoffs to local dietary patterns to improve accuracy. WHO and UNICEF should revisit the global application of a uniform cutoff and support the development of context-specific thresholds. This study in Ethiopia underscores the importance of further research to reassess the effectiveness of MDD-C as a proxy indicator for determining micronutrient adequacy across diverse populations and multiple countries. CI - Copyright: (c) 2025 Menber et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Menber, Yonatan AU - Menber Y AUID- ORCID: 0000-0002-0741-9395 AD - Department of Nutrition and Dietetics, School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia. FAU - Belachew, Tefera AU - Belachew T AD - Department of Nutrition and Dietetics, Faculty of Public Health, Institute of Health, Jimma University, Jimma, Ethiopia. FAU - Fentahun, Netsanet AU - Fentahun N AD - Department of Nutrition and Dietetics, School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia. LA - eng PT - Journal Article PT - Validation Study DEP - 20251017 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Micronutrients) SB - IM MH - Humans MH - Ethiopia MH - Infant MH - *Micronutrients/analysis MH - Female MH - Male MH - Cross-Sectional Studies MH - *Diet MH - *Feeding Behavior MH - Nutritional Status MH - ROC Curve PMC - PMC12533918 COIS- The authors have declared that no competing interests exist. EDAT- 2025/10/17 18:27 MHDA- 2025/10/17 18:28 PMCR- 2025/10/17 CRDT- 2025/10/17 13:35 PHST- 2024/09/04 00:00 [received] PHST- 2025/10/02 00:00 [accepted] PHST- 2025/10/17 18:28 [medline] PHST- 2025/10/17 18:27 [pubmed] PHST- 2025/10/17 13:35 [entrez] PHST- 2025/10/17 00:00 [pmc-release] AID - PONE-D-24-37223 [pii] AID - 10.1371/journal.pone.0334827 [doi] PST - epublish SO - PLoS One. 2025 Oct 17;20(10):e0334827. doi: 10.1371/journal.pone.0334827. eCollection 2025. PMID- 41102035 OWN - NLM STAT- MEDLINE DCOM- 20251116 LR - 20260918 IS - 1879-291X (Electronic) IS - 0301-5629 (Print) IS - 0301-5629 (Linking) VI - 52 IP - 1 DP - 2026 Jan TI - Enhancing Newborn Health Assessment: Ultrasound-based Body Composition Prediction Using Deep Learning Techniques. PG - 207-215 LID - S0301-5629(25)00381-3 [pii] LID - 10.1016/j.ultrasmedbio.2025.09.016 [doi] AB - OBJECTIVE: This study investigates the feasibility of deep learning to predict body composition with ultrasound, specifically fat mass (FM) and fat-free mass (FFM), to improve newborn health assessments. METHODS: We analyzed 721 ultrasound images of the biceps, quadriceps and abdomen from 65 pre-term infants. A deep learning model incorporating a modified U-Net architecture was developed to predict FM and FFM using air displacement plethysmography as ground truth labels for training. Model performance was assessed using mean absolute error (MAE), mean squared error (MSE), root mean square error (RMSE) and mean absolute percentage error (MAPE), along with Bland-Altman plots to evaluate mean bias and limits of agreement. We tested different image combinations to determine the contribution of anatomical regions. Grad-CAM was applied to identify image regions with the strongest influence on predictions. RESULTS: Combining biceps, quadriceps and abdominal ultrasound images to predict whole-body composition showed strong agreement with ground truth values, with low MAE (FM: 0.0145 kg, FFM: 0.0794 kg), MSE (FM: 0.0003 kg(2), FFM: 0.0073 kg(2)), RMSE (FM: 0.0183 kg, FFM: 0.0854 kg) and MAPE (FM: 2.65%, FFM: 8.40%). Using only abdominal images for prediction improved FFM performance (MAPE = 4.62%, MSE = 0.0041 kg(2), RMSE = 0.0486 kg, MAE = 0.0378 kg). Grad-CAM revealed muscle regions as key contributors to FM and FFM predictions. CONCLUSION: Deep learning provides a promising approach to predicting body composition with ultrasound and could be a valuable tool for assessing nutritional status in neonatal care. CI - Copyright (c) 2025 World Federation for Ultrasound in Medicine and Biology. Published by Elsevier Inc. All rights reserved. FAU - He, Keshi AU - He K AD - Department of Engineering, Boston College, Chestnut Hill, MA, USA. FAU - Hohenberg, Julia AU - Hohenberg J AD - Department of Computer Science, Boston College, Chestnut Hill, MA, USA. FAU - Li, Yi AU - Li Y AD - Department of Computer Science, Boston College, Chestnut Hill, MA, USA. FAU - Xiao, Audrey AU - Xiao A AD - Department of Engineering, Boston College, Chestnut Hill, MA, USA. FAU - Cho, Hayoung AU - Cho H AD - Department of Engineering, Boston College, Chestnut Hill, MA, USA. FAU - Nagel, Emily AU - Nagel E AD - Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA. FAU - Ramel, Sara AU - Ramel S AD - Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA. FAU - Bell, Katherine A AU - Bell KA AD - Department of Pediatrics, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. FAU - Wei, Donglai AU - Wei D AD - Department of Computer Science, Boston College, Chestnut Hill, MA, USA. FAU - Park, Jinhee AU - Park J AD - Connell School of Nursing, Boston College, Chestnut Hill, MA, USA. FAU - Ranger, Bryan J AU - Ranger BJ AD - Department of Engineering, Boston College, Chestnut Hill, MA, USA; Connell School of Nursing, Boston College, Chestnut Hill, MA, USA. Electronic address: bryan.ranger@bc.edu. LA - eng GR - K23 HD104000/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20251016 PL - England TA - Ultrasound Med Biol JT - Ultrasound in medicine & biology JID - 0410553 SB - IM MH - Humans MH - *Deep Learning MH - Infant, Newborn MH - *Body Composition/physiology MH - Ultrasonography/methods MH - Male MH - Female MH - Feasibility Studies MH - Abdomen/diagnostic imaging PMC - PMC12614439 MID - NIHMS2112232 OTO - NOTNLM OT - Body composition prediction OT - Deep learning OT - Malnutrition OT - Newborn and child health OT - Ultrasound imaging COIS- Conflict of interest The authors declare no competing interests. EDAT- 2025/10/17 00:31 MHDA- 2025/11/17 00:28 PMCR- 2026/07/17 CRDT- 2025/10/16 22:34 PHST- 2025/03/07 00:00 [received] PHST- 2025/09/10 00:00 [revised] PHST- 2025/09/15 00:00 [accepted] PHST- 2025/11/17 00:28 [medline] PHST- 2025/10/17 00:31 [pubmed] PHST- 2025/10/16 22:34 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - S0301-5629(25)00381-3 [pii] AID - 10.1016/j.ultrasmedbio.2025.09.016 [doi] PST - ppublish SO - Ultrasound Med Biol. 2026 Jan;52(1):207-215. doi: 10.1016/j.ultrasmedbio.2025.09.016. Epub 2025 Oct 16. PMID- 41101989 OWN - NLM STAT- MEDLINE DCOM- 20251016 LR - 20260220 IS - 1445-6354 (Electronic) IS - 1445-6354 (Linking) VI - 25 IP - 4 DP - 2025 Oct TI - 'We feel better here now': traditional practices, sanitation, and dialog with the biomedical system to restore spiritual harmony in an Indigenous community in Colombia. PG - 9126 LID - 10.22605/RRH9126 [doi] AB - INTRODUCTION: Suicidal behavior has increased in the past decade, particularly among Indigenous children and adolescents. This study explores variables associated with spiritual harmony - understood by Indigenous Peoples of Colombia as holistic mental health - among displaced Embera Dobidá youth, focusing on food security, general health, and connection to the land. It also evaluates outcomes of community-led and interculturally coordinated strategies implemented between 2023 and 2025. METHODS: A descriptive longitudinal study was conducted with all children aged 6 to 17 years (mean 14.97 years) from an Embera Dobidá community displaced by armed conflict. Data were collected at two time points (January 2023 and January 2025) using culturally validated instruments (Parenting, Behavior, Emotions, and Suicide Risk scale, Brief Solastalgia Scale and food security scale) and pediatric assessments. Interventions included traditional ceremonies, sanitation improvements, intercultural mental health support, and psychological first aid adapted to local cosmovision. Bivariate analyses were performed. RESULTS: In 2023, 57.4% of participants had nutritional problems and 30% were at suicide risk. Strong associations (p<0.001) were found between suicide risk and variables such as access to clean water and to food, environmental distress, and physical health. By 2025, significant improvements were observed in mental health (r=0.86), food security (r=0.84), environmental distress (r=0.61), and family dynamics (attachment r=0.58). DISCUSSION: Suicidal behavior is closely linked to ecological, cultural, and nutritional factors rather than only psychiatric disorders. Forced displacement, disconnection from ancestral territory, and spiritual disharmony are central elements. CONCLUSION: Restoring mental health in Indigenous communities requires culturally grounded interventions that integrate nutrition, land-based practices, and intercultural collaboration. These strategies demonstrate potential for addressing pediatric suicide risk through culturally grounded, collective healing. FAU - Agudelo-Hernandez, Felipe AU - Agudelo-Hernandez F AD - Psychiatry, University of Manizales, Manizales, Caldas, Colombia. FAU - Mecha-Chamorro, Jaramillo AU - Mecha-Chamorro J AD - Embera Community of Caucamorro, Anserma, Caldas, Colombia. FAU - Marulanda-Lopez, Eduardo AU - Marulanda-Lopez E AD - Public Health, University of Manizales, Manizales, Caldas, Colombia. LA - eng PT - Journal Article DEP - 20251016 PL - Australia TA - Rural Remote Health JT - Rural and remote health JID - 101174860 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Colombia/ethnology MH - *Indians, South American/psychology MH - Longitudinal Studies MH - Mental Health/ethnology MH - *Sanitation MH - *Spirituality MH - Suicide Prevention OTO - NOTNLM OT - Indigenous Peoples OT - food security OT - intercultural health OT - pediatric mental health OT - spiritual harmony OT - suicide OT - Colombia EDAT- 2025/10/17 00:31 MHDA- 2025/10/17 00:32 CRDT- 2025/10/16 21:23 PHST- 2025/10/17 00:32 [medline] PHST- 2025/10/17 00:31 [pubmed] PHST- 2025/10/16 21:23 [entrez] AID - 9126 [pii] AID - 10.22605/RRH9126 [doi] PST - ppublish SO - Rural Remote Health. 2025 Oct;25(4):9126. doi: 10.22605/RRH9126. Epub 2025 Oct 16. PMID- 41100848 OWN - NLM STAT- MEDLINE DCOM- 20251016 LR - 20260811 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 9 DP - 2025 Oct 16 TI - Toward Comprehensive Assessment of Beliefs and Attitudes Related to Physical Activity in Young Adults: Pilot Study. PG - e69094 LID - 10.2196/69094 [doi] LID - e69094 AB - BACKGROUND: Studies show that despite the positive effects of physical activity (PA), most university students are not active enough. For interventions, it is necessary to understand the determinants of PA behavior. Theory of planned behavior (TPB) is one of the most widely used frameworks to describe the psychological determinants of health behavior. Research has shown that in addition to the determinants included in TPB (attitudes, subjective norms, perceived control, and intention), fear of negative outcomes (eg, discomfort or pain) is a major barrier to increasing one's PA. It has been shown that accepting the possibility of unpleasant outcomes may help in reaching one's PA goals. OBJECTIVE: The purpose of this study was to create a questionnaire of PA determinants based on TPB and complemented by the topic of acceptance of unpleasant outcomes. The questionnaire is thus meant for evaluating the effectiveness of health psychological PA interventions in university students and young adults. METHODS: This study was carried out using qualitative and quantitative methods and consisted of three phases: (1) an elicitation study for item generation, (2) pretesting for clarity and understanding, and (3) item selection using conceptual and psychometric criteria (based on a pretest with N=447) to maximize domain coverage and avoid redundancy. RESULTS: A questionnaire covering the core topics of TPB plus acceptance of negative outcomes was constructed, using a combination of qualitative and quantitative methods. The final shortened questionnaire consists of the following question blocks: positive and negative behavioral beliefs, acceptance of negative outcomes, subjective norms (injunctive and descriptive norms, and motivation to comply), and control beliefs. In terms of predicting self-reported PA, the shortened questionnaire was equal to the unabridged version. Notably, negative behavioral beliefs and acceptance of negative outcomes had opposite-signed correlations with self-reported PA (-0.22 and 0.32, P<.001). Despite the aim of avoiding redundancy, several item bundles (eg, positive and negative behavioral beliefs, and acceptance of negative outcomes) were highly homogenous in the final version, and are thus usable as psychometric scales. CONCLUSIONS: This questionnaire can assess a range of PA determinants and has good psychometric properties. The questionnaire can be used to assess the beliefs and attitudes (behavioral beliefs, perceived norms, control beliefs, and acceptance of negative consequences) related to PA in young adults when planning interventions, as well as evaluating the effects of health psychological interventions aiming to increase PA. CI - (c)Theodorus D B Noordover, Aave Hannus, Kenn Konstabel. Originally published in JMIR Formative Research (https://formative.jmir.org), 16.10.2025. FAU - Noordover, Theodorus D B AU - Noordover TDB AUID- ORCID: 0009-0009-8033-8661 AD - Department of Psychology, University of Tartu, Tartu, Estonia. AD - National Institute for Health Development, Tallinn, Estonia. FAU - Hannus, Aave AU - Hannus A AUID- ORCID: 0000-0002-0912-0661 AD - Department of Psychology, University of Tartu, Tartu, Estonia. AD - National Institute for Health Development, Tallinn, Estonia. FAU - Konstabel, Kenn AU - Konstabel K AUID- ORCID: 0000-0002-9673-8469 AD - Department of Psychology, University of Tartu, Tartu, Estonia. AD - National Institute for Health Development, Tallinn, Estonia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251016 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - *Exercise/psychology MH - Pilot Projects MH - Female MH - Male MH - Young Adult MH - Surveys and Questionnaires MH - *Students/psychology MH - Adult MH - Psychometrics MH - *Health Behavior MH - *Health Knowledge, Attitudes, Practice MH - Universities MH - Adolescent PMC - PMC12576300 OTO - NOTNLM OT - acceptance and commitment therapy OT - physical activity OT - questionnaire OT - theory of planned behavior OT - university students COIS- Conflicts of Interest: None declared. EDAT- 2025/10/16 18:36 MHDA- 2025/10/16 18:37 PMCR- 2025/10/16 CRDT- 2025/10/16 16:52 PHST- 2024/11/21 00:00 [received] PHST- 2025/08/13 00:00 [accepted] PHST- 2025/04/17 00:00 [revised] PHST- 2025/10/16 18:37 [medline] PHST- 2025/10/16 18:36 [pubmed] PHST- 2025/10/16 16:52 [entrez] PHST- 2025/10/16 00:00 [pmc-release] AID - v9i1e69094 [pii] AID - 10.2196/69094 [doi] PST - epublish SO - JMIR Form Res. 2025 Oct 16;9:e69094. doi: 10.2196/69094. PMID- 41099405 OWN - NLM STAT- MEDLINE DCOM- 20260317 LR - 20260813 IS - 1531-4995 (Electronic) IS - 0023-852X (Print) IS - 0023-852X (Linking) VI - 136 IP - 4 DP - 2026 Apr TI - Early Surgery Reduces Psychiatric and Learning Disorder Risk in Pediatric Sleep-Disordered Breathing. PG - 1928-1937 LID - 10.1002/lary.70205 [doi] AB - OBJECTIVE: To determine whether the type and timing of intervention for pediatric sleep-disordered breathing (SDB) affect the risk of developing neuropsychiatric and learning disorders. METHODS: A retrospective cohort study using TriNetX, from January 2016 to March 2025, was conducted. Patients < 18 years with a diagnosis of SDB were included. Propensity score matching (1:1) based on demographics and concomitant diagnoses was performed for three comparisons: untreated versus surgical management (n = 152,653), untreated versus non-surgical management (n = 8,634), and surgical versus non-surgical management (n = 8,873). The incidence of anxiety, depressive, eating, behavioral, and learning disorders at 1 year, 5 years, and anytime post-intervention was recorded. In surgical patients, outcomes were also stratified by timing of surgery: within versus beyond 3, 6, and 12 months of diagnosis. RESULTS: Compared to surgery, no treatment was associated with significantly elevated risk of anxiety (risk ratio [RR] 1.44), depressive (RR 1.71), eating (RR 1.27), behavioral (RR 1.31), and learning disorders (RR 1.39) at 1 year. Compared to surgery, non-surgical management significantly increased the risk of anxiety (RR 2.27), depressive (RR 1.69), behavioral (RR 1.24), and learning disorders (RR 2.72) at 1 year. Similar trends were observed at 5 years. Surgery within 6 months significantly reduced the risk of anxiety (RR 1.06), eating (RR 1.38), behavioral (RR 1.12), and learning disorders (RR 1.14) (p < 0.05 for all comparisons). CONCLUSION: Early surgical intervention for pediatric SDB is associated with significantly lower risks of neuropsychiatric and learning disorders compared to delayed surgery, non-surgical management, or no treatment, necessitating validation through future prospective trials. CI - (c) 2025 The Author(s). The Laryngoscope published by Wiley Periodicals LLC on behalf of The American Laryngological, Rhinological and Otological Society, Inc. FAU - Campbell, Daniel J AU - Campbell DJ AUID- ORCID: 0000-0001-9001-5705 AD - Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospitals, Philadelphia, Pennsylvania, USA. AD - Nemour's Childrens Health, Delaware Valley, Wilmington, Delaware, USA. FAU - Palmer, W Jack AU - Palmer WJ AUID- ORCID: 0000-0002-0504-7276 AD - Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospitals, Philadelphia, Pennsylvania, USA. AD - Nemour's Childrens Health, Delaware Valley, Wilmington, Delaware, USA. FAU - Estephan, Leonard E AU - Estephan LE AUID- ORCID: 0000-0001-9599-1510 AD - Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospitals, Philadelphia, Pennsylvania, USA. AD - Nemour's Childrens Health, Delaware Valley, Wilmington, Delaware, USA. FAU - Samarah, Hani AU - Samarah H AD - Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospitals, Philadelphia, Pennsylvania, USA. FAU - Sina, Elliott AU - Sina E AUID- ORCID: 0009-0004-8473-8965 AD - Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospitals, Philadelphia, Pennsylvania, USA. FAU - Aaronson, Nicole AU - Aaronson N AUID- ORCID: 0000-0002-3028-453X AD - Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospitals, Philadelphia, Pennsylvania, USA. AD - Nemour's Childrens Health, Delaware Valley, Wilmington, Delaware, USA. FAU - Parkes, William AU - Parkes W AD - Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospitals, Philadelphia, Pennsylvania, USA. AD - Nemour's Childrens Health, Delaware Valley, Wilmington, Delaware, USA. LA - eng PT - Journal Article DEP - 20251016 PL - United States TA - Laryngoscope JT - The Laryngoscope JID - 8607378 SB - IM MH - Humans MH - Male MH - Female MH - Retrospective Studies MH - *Sleep Apnea Syndromes/surgery/psychology/complications MH - Child MH - *Learning Disabilities/prevention & control/etiology/epidemiology MH - Child, Preschool MH - Adolescent MH - *Mental Disorders/prevention & control/etiology/epidemiology MH - Infant MH - Propensity Score MH - Incidence MH - *Time-to-Treatment MH - Anxiety/epidemiology/etiology PMC - PMC12993109 OTO - NOTNLM OT - obstructive sleep apnea OT - pediatrics OT - quality of life OT - sleep OT - surgical treatment of obstructive sleep apnea COIS- The authors declare no conflicts of interest. EDAT- 2025/10/16 12:32 MHDA- 2026/03/17 06:48 PMCR- 2026/03/17 CRDT- 2025/10/16 08:13 PHST- 2025/09/10 00:00 [revised] PHST- 2025/07/02 00:00 [received] PHST- 2025/10/08 00:00 [accepted] PHST- 2026/03/17 06:48 [medline] PHST- 2025/10/16 12:32 [pubmed] PHST- 2025/10/16 08:13 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - LARY70205 [pii] AID - 10.1002/lary.70205 [doi] PST - ppublish SO - Laryngoscope. 2026 Apr;136(4):1928-1937. doi: 10.1002/lary.70205. Epub 2025 Oct 16. PMID- 41098338 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251016 LR - 20260925 IS - 2948-1570 (Electronic) IS - 2948-1570 (Linking) VI - 3 DP - 2025 TI - Measuring activation during behavioral activation therapy: a proof-of-concept study using smartphone sensors and LLM-derived ratings in adolescents with anhedonia. PG - 24 LID - 10.1038/s44277-025-00045-w [doi] LID - 24 AB - Adolescent depression remains a major public health concern, and Behavioral Activation (BA), a brief therapeutic intervention designed to reduce depression-related avoidance and boost engagement in rewarding activities, has shown encouraging results. Still, few studies directly measure the hypothesized mechanism of "activation" in daily life, especially using low-burden, ecologically valid methods. This proof-of-concept study evaluates the validity of two technology-based approaches to measuring activation in adolescents receiving BA: smartphone-based mobility sensing and large language model (LLM) ratings of free-response text. Adolescents (n = 38, ages 13-18) receiving 12-week BA therapy for anhedonia completed daily ecological momentary assessment (EMA) reporting on positive and negative affect. GPT-4o was used to rate behavioral activation from EMA free-text entries. A subsample (n = 13) contributed passive smartphone sensing data (e.g., accelerometer activity, GPS-derived mobility). Activation and symptoms were assessed weekly via self-report. GPT-derived activation ratings correlated positively with passive sensing indicators (number of places visited, time away from home) and self-reported activation. Within-person increases in GPT-rated activation were associated with higher daily positive affect and lower negative affect. Passive sensing features also forecasted weekly improvements in anhedonia and depressive symptoms. Associations emerged primarily at the within-person level, suggesting that changes in activation relative to one's own baseline are clinically meaningful. This study demonstrates the feasibility and validity of passively measuring behavioral activation in adolescents' daily lives using smartphone data and LLMs. These tools hold promise for advancing data-informed psychotherapy by tracking therapeutic processes in real time, reducing reliance on self-report, and enabling personalized, adaptive interventions. Clinical Trial Registry: NCT02498925. CI - (c) The Author(s) 2025. FAU - Fisher, Hadar AU - Fisher H AUID- ORCID: 0000-0002-3421-3966 AD - McLean Hospital, Belmont, MA USA. ROR: https://ror.org/01kta7d96. GRID: grid.240206.2. ISNI: 0000 0000 8795 072X AD - Department of Psychiatry, Harvard Medical School, Boston, MA USA. ROR: https://ror.org/03vek6s52. GRID: grid.38142.3c. ISNI: 000000041936754X FAU - Jaffe, Nigel M AU - Jaffe NM AUID- ORCID: 0000-0001-7405-8094 AD - McLean Hospital, Belmont, MA USA. ROR: https://ror.org/01kta7d96. GRID: grid.240206.2. ISNI: 0000 0000 8795 072X FAU - Rahimi-Eichi, Habiballah AU - Rahimi-Eichi H AD - McLean Hospital, Belmont, MA USA. ROR: https://ror.org/01kta7d96. GRID: grid.240206.2. ISNI: 0000 0000 8795 072X AD - Department of Psychiatry, Harvard Medical School, Boston, MA USA. ROR: https://ror.org/03vek6s52. GRID: grid.38142.3c. ISNI: 000000041936754X FAU - Forbes, Erika E AU - Forbes EE AD - Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA USA. ROR: https://ror.org/01an3r305. GRID: grid.21925.3d. ISNI: 0000 0004 1936 9000 FAU - Pizzagalli, Diego A AU - Pizzagalli DA AD - McLean Hospital, Belmont, MA USA. ROR: https://ror.org/01kta7d96. GRID: grid.240206.2. ISNI: 0000 0000 8795 072X AD - Department of Psychiatry, Harvard Medical School, Boston, MA USA. ROR: https://ror.org/03vek6s52. GRID: grid.38142.3c. ISNI: 000000041936754X AD - Noel Drury, M.D. Institute for Translational Depression Discoveries, University of California, Irvine, CA USA. ROR: https://ror.org/04gyf1771. GRID: grid.266093.8. ISNI: 0000 0001 0668 7243 FAU - Baker, Justin T AU - Baker JT AD - McLean Hospital, Belmont, MA USA. ROR: https://ror.org/01kta7d96. GRID: grid.240206.2. ISNI: 0000 0000 8795 072X AD - Department of Psychiatry, Harvard Medical School, Boston, MA USA. ROR: https://ror.org/03vek6s52. GRID: grid.38142.3c. ISNI: 000000041936754X FAU - Webb, Christian A AU - Webb CA AUID- ORCID: 0000-0002-8310-4539 AD - McLean Hospital, Belmont, MA USA. ROR: https://ror.org/01kta7d96. GRID: grid.240206.2. ISNI: 0000 0000 8795 072X AD - Department of Psychiatry, Harvard Medical School, Boston, MA USA. ROR: https://ror.org/03vek6s52. GRID: grid.38142.3c. ISNI: 000000041936754X LA - eng SI - ClinicalTrials.gov/NCT02498925 GR - P50 MH119467/MH/NIMH NIH HHS/United States GR - R01 AT011002/AT/NCCIH NIH HHS/United States GR - R37 MH068376/MH/NIMH NIH HHS/United States GR - K23 MH108752/MH/NIMH NIH HHS/United States GR - R01 MH116969/MH/NIMH NIH HHS/United States GR - R01 MH135844/MH/NIMH NIH HHS/United States PT - Journal Article DEP - 20251013 PL - Switzerland TA - NPP Digit Psychiatry Neurosci JT - NPP - digital psychiatry and neuroscience JID - 9918843683806676 PMC - PMC12518126 OAB - Behavioral Activation therapy helps depressed teens by encouraging them to engage in more rewarding activities. We tested whether smartphones and LLM could automatically track this 'activation' in daily life. Using movement data from phones and LLM-based ratings from 38 teens in therapy, we found these digital tools accurately detected when teens were more active and higher activation predicted better mood and fewer depression symptoms. This technology could help therapists monitor progress in real-time and personalize treatment more effectively. OABL- eng OTO - NOTNLM OT - Outcomes research OT - Therapeutics COIS- Competing interestsOver the past three years, Dr. Pizzagalli has received consulting fees from Arrowhead Pharmaceuticals, Boehringer Ingelheim, Compass Pathways, Engrail Therapeutics, Neumora Therapeutics, Neurocrine Biosciences, Neuroscience Software, Sage Therapeutics, Sama Therapeutics, and Takeda; he has received honoraria from the American Psychological Association, Psychonomic Society and Springer (for editorial work) and from Alkermes; he has received research funding from the BIRD Foundation, Brain and Behavior Research Foundation, Dana Foundation, DARPA, Millennium Pharmaceuticals, NIMH and Wellcome Leap MCPsych; he has received stock options from Ceretype Neuromedicine, Compass Pathways, Engrail Therapeutics, Neumora Therapeutics, and Neuroscience Software. Dr. Webb has received consulting fees from King & Spalding law firm. Dr. Baker has received consulting fees from Sama Therapeutics and Tetricus Labs, Inc. Dr. Baker is currently a Senior Editor at Digital Psychiatry and Neuroscience. Dr. Pizzagalli's, Dr. Webb's, and Dr. Baker's interests were reviewed and are managed by McLean Hospital and Mass General Brigham in accordance with their conflict of interest policies. No funding from these entities was used to support the current work, and all views expressed are solely those of the authors. The other authors declare no competing financial interests. EDAT- 2025/10/16 06:29 MHDA- 2025/10/16 06:30 PMCR- 2025/10/13 CRDT- 2025/10/16 04:38 PHST- 2025/06/30 00:00 [received] PHST- 2025/09/09 00:00 [revised] PHST- 2025/09/24 00:00 [accepted] PHST- 2025/10/16 06:30 [medline] PHST- 2025/10/16 06:29 [pubmed] PHST- 2025/10/16 04:38 [entrez] PHST- 2025/10/13 00:00 [pmc-release] AID - 45 [pii] AID - 10.1038/s44277-025-00045-w [doi] PST - epublish SO - NPP Digit Psychiatry Neurosci. 2025 Oct 13;3:24. doi: 10.1038/s44277-025-00045-w. eCollection 2025. PMID- 41097260 OWN - NLM STAT- MEDLINE DCOM- 20251016 LR - 20251118 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 19 DP - 2025 Oct 9 TI - Association Between Adiposity Rebound and the Frequency of Balanced Meals Among Japanese Preschool Children: A Cross-Sectional Study. LID - 10.3390/nu17193183 [doi] LID - 3183 AB - BACKGROUND: The Healthy Japan 21-Phase III dietary recommendations comprise a staple food, main dish, and side dish to maintain nutritional balance and support healthy child growth. The relationship between the frequency of such balanced meals and early adiposity rebound (AR), a predictor of obesity, remains unclear. OBJECTIVE: This study aimed to examine the association between the frequency of balanced meals (staple food, main dish, and side dish) and early AR in preschool children. METHODS: In this cross-sectional secondary analysis of nationwide online survey data of 688 mothers of children aged 3-6 years, dietary habits were assessed using a validated NutriSTEP-based 22-item Japanese Nutrition Screening Questionnaire. AR constituted a body mass index (BMI) increase from the 18- to 36-month health checkups recorded in the Maternal and Child Health Handbook. Risk scores reflecting lower frequency of balanced meals were calculated for staple foods, main dishes, and side dishes. Logistic regression evaluated associations between dietary risk scores and AR, adjusting for the child's sex, age, gestational age, birth weight, daycare attendance, and parental obesity. RESULTS: Among 688 children, 193 (28.1%) exhibited early AR and had significantly higher BMI at age 3 and the most recent measurement (both p < 0.01). A higher total dietary risk score was independently associated with AR (adjusted odds ratio; 2.58 [95% CI: 1.08-6.16]). In addition, the absolute risk difference between high- and low-risk groups was 8.5% (95% CI: 1.7-15.2%). CONCLUSIONS: A lower frequency of balanced meals is associated with early AR. These findings suggest that a simple, meal-balance screening tool could potentially aid in the early identification of the risk of later obesity and timely nutritional guidance. FAU - Tada, Yuki AU - Tada Y AUID- ORCID: 0000-0003-1292-6110 AD - Department of Nutritional Science, Tokyo University of Agriculture, Tokyo 156-8502, Japan. FAU - Sasaki, Kemal AU - Sasaki K AD - Department of Food and Health Sciences, Jissen Women's University, Tokyo 191-8510, Japan. FAU - Kobayashi, Tomomi AU - Kobayashi T AD - Department of Food Science and Nutrition, Mukogawa Women's University, Nishinomiya 663-8558, Japan. FAU - Wada, Yasuyo AU - Wada Y AD - Department of Health Promotion, National Institute of Public Health, Wako 351-0197, Japan. FAU - Fujita, Daisuke AU - Fujita D AD - Department of Food and Nutritional Science, Graduate School of Applied Bioscience, Tokyo University of Agriculture, Tokyo 156-8502, Japan. FAU - Yokoyama, Tetsuji AU - Yokoyama T AUID- ORCID: 0000-0002-7699-6882 AD - Department of Health Promotion, National Institute of Public Health, Wako 351-0197, Japan. LA - eng GR - JPCA21DA2001/2024 Fiscal Year Child and Family Administration Promotion Research Grant/ PT - Journal Article DEP - 20251009 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - Japanese people SB - IM MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Male MH - *Adiposity MH - Body Mass Index MH - Child Nutritional Physiological Phenomena MH - Cross-Sectional Studies MH - Diet MH - *Feeding Behavior MH - Japan/epidemiology MH - *Meals MH - *Pediatric Obesity/epidemiology/etiology MH - East Asian People/statistics & numerical data PMC - PMC12526273 OTO - NOTNLM OT - Japanese OT - adiposity rebound OT - dietary intake OT - preschool child COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. EDAT- 2025/10/16 06:30 MHDA- 2025/10/16 06:31 PMCR- 2025/10/09 CRDT- 2025/10/16 01:15 PHST- 2025/08/15 00:00 [received] PHST- 2025/10/03 00:00 [revised] PHST- 2025/10/06 00:00 [accepted] PHST- 2025/10/16 06:31 [medline] PHST- 2025/10/16 06:30 [pubmed] PHST- 2025/10/16 01:15 [entrez] PHST- 2025/10/09 00:00 [pmc-release] AID - nu17193183 [pii] AID - nutrients-17-03183 [pii] AID - 10.3390/nu17193183 [doi] PST - epublish SO - Nutrients. 2025 Oct 9;17(19):3183. doi: 10.3390/nu17193183. PMID- 41097216 OWN - NLM STAT- MEDLINE DCOM- 20251016 LR - 20251019 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 19 DP - 2025 Sep 30 TI - Breaking the Cycle of Malnutrition: The Role of Food and Nutrition Literacy in Addressing Food Insecurity Among Lebanese Adolescents. LID - 10.3390/nu17193140 [doi] LID - 3140 AB - Background: Undernutrition and overnutrition are considered a rising challenge among adolescents in low- and middle-income countries, including Lebanon, where overlapping economic, political, and public health crises have worsened food insecurity. Food and nutrition literacy in adolescents may serve as protective factors against food insecurity and its nutritional consequences. This study aims to evaluate the associations between adolescent and parental food and nutrition literacy with household and adolescent food insecurity, and explores their relationship with stunting and overweight/obesity. Methodology: A cross-sectional survey was conducted between March and July 2022 among 442 Lebanese adolescents (10-18 years) and one parent/caregiver per household, recruited via snowball sampling from all eight governorates. Validated tools assessed adolescent food and nutrition literacy, parental food literacy, household/adolescent food insecurity, and anthropometric status. Chi-square, t-tests, and multivariable logistic regressions identified factors associated with food insecurity, stunting, and overweight/obesity. Results: Higher adolescent food and nutrition literacy was significantly associated with lower odds of severe food insecurity (aOR = 0.43, 95% CI: 0.26-0.70). Higher parental food literacy scores were linked to reduced odds of severe household food insecurity (aOR = 0.94, 95% CI: 0.90-0.98). Severe food insecurity was more likely in households in Akkar and among adolescents not attending school or with poor food and nutrition literacy. Overweight/obesity was positively associated with attending private school and higher parental body mass index, but inversely associated with higher child food security and household crowding index. No significant association was found between food insecurity and stunting. Conclusions: Both adolescent and parental food and nutrition literacy are protective against severe food insecurity, highlighting the value of literacy-focused interventions alongside economic support measures. Addressing both educational and structural determinants may help break the cycle of malnutrition in crisis-affected Lebanese youth. FAU - Ghadban, Elie AU - Ghadban E AUID- ORCID: 0009-0005-3357-497X AD - Department of Plastic Surgery, Saint George University of Beirut Achrafieh, Beirut, Lebanon. FAU - Boutros, Tigresse AU - Boutros T AD - School of Medicine and Medical Sciences, Holy Spirit University of Kaslik, Jounieh P.O. Box 446, Lebanon. FAU - Hallit, Souheil AU - Hallit S AUID- ORCID: 0000-0001-6918-5689 AD - School of Medicine and Medical Sciences, Holy Spirit University of Kaslik, Jounieh P.O. Box 446, Lebanon. AD - Department of Psychology, College of Humanities, Effat University, Jeddah 21478, Saudi Arabia. AD - Applied Science Research Center, Applied Science Private University, Amman 11937, Jordan. FAU - Tzenios, Nikolaos AU - Tzenios N AUID- ORCID: 0000-0002-6679-2296 AD - Faculty of Public Health, Charisma University, London EC1V 7QE, UK. FAU - Sacre, Yonna AU - Sacre Y AD - Department of Nutrition and Food Sciences, Faculty of Arts and Sciences, Holy Spirit University of Kaslik (USEK), Jounieh P.O. Box 446, Lebanon. FAU - Hoteit, Maha AU - Hoteit M AUID- ORCID: 0000-0001-7392-4835 AD - PHENOL Research Program, Faculty of Public Health, Section 1, Lebanese University, Beirut P.O. Box 6573, Lebanon. AD - Department of Primary Care and Population Health, University of Nicosia Medical School, 2417 Nicosia, Cyprus. AD - INSPECT-LB (Institut National de Sante Publique, d'Epidemiologie Clinique et de Toxicologie-Liban), Beirut, Lebanon. LA - eng PT - Journal Article DEP - 20250930 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - Lebanon/epidemiology MH - Male MH - Female MH - *Food Insecurity MH - Cross-Sectional Studies MH - Child MH - *Health Literacy MH - *Malnutrition/epidemiology/prevention & control MH - Growth Disorders/epidemiology MH - Nutritional Status MH - Parents MH - Pediatric Obesity/epidemiology MH - Overweight/epidemiology MH - Family Characteristics PMC - PMC12526276 OTO - NOTNLM OT - Lebanon OT - adolescents OT - food insecurity OT - food literacy OT - nutrition literacy OT - obesity/overweight OT - stunting COIS- The authors declare no conflicts of interest. EDAT- 2025/10/16 06:29 MHDA- 2025/10/16 06:30 PMCR- 2025/09/30 CRDT- 2025/10/16 01:15 PHST- 2025/09/02 00:00 [received] PHST- 2025/09/29 00:00 [revised] PHST- 2025/09/30 00:00 [accepted] PHST- 2025/10/16 06:30 [medline] PHST- 2025/10/16 06:29 [pubmed] PHST- 2025/10/16 01:15 [entrez] PHST- 2025/09/30 00:00 [pmc-release] AID - nu17193140 [pii] AID - nutrients-17-03140 [pii] AID - 10.3390/nu17193140 [doi] PST - epublish SO - Nutrients. 2025 Sep 30;17(19):3140. doi: 10.3390/nu17193140. PMID- 41097209 OWN - NLM STAT- MEDLINE DCOM- 20251016 LR - 20260115 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 19 DP - 2025 Sep 30 TI - A School-Based Five-Month Gardening Intervention Improves Vegetable Intake, BMI, and Nutrition Knowledge in Primary School Children: A Controlled Quasi-Experimental Trial. LID - 10.3390/nu17193133 [doi] LID - 3133 AB - Background/Objectives: Childhood obesity rates in Jordan have reached alarming levels, with 28% of school-age children classified as overweight or obese. School-based gardening interventions show promise for promoting healthy eating behaviors, yet limited research exists in Middle Eastern contexts. This study evaluated the effectiveness of a five-month school-based vegetable gardening and nutrition education intervention on anthropometric measures, dietary intake, and knowledge, attitudes, and practices (KAP) regarding vegetable consumption among Jordanian primary school children. Methods: A quasi-experimental controlled trial was conducted with 216 students (ages 10-12 years) from two demographically matched schools in Amman, Jordan. The intervention group (n = 121) participated in weekly one-hour gardening sessions combined with nutrition education and vegetable tasting activities over five months, while the control group (n = 95) continued the standard curriculum. Outcomes measured at baseline and post-intervention included anthropometric assessments, dietary intake via 24 h recalls, and vegetable-related KAP using a validated questionnaire. Data were analyzed using paired t-tests and repeated measures ANCOVA. Results: The intervention group demonstrated significant improvements in body composition, including reductions in BMI (-1.57 kg/m(2)), weight (-1.88 kg), and BMI z-score (-0.37), while controls showed minimal increases. Vegetable intake showed significant time x group interaction (p-value = 0.003), with a non-significant increase in the intervention group (2.7 to 2.9 times/day) and a non-significant decrease in the controls (2.5 to 2.4 times/day). Dietary quality improved, including increased fiber intake (+2.36 g/day) and reduced saturated fat consumption (-9.24 g/day). Nutrition knowledge scores increased substantially in the intervention group (+22.31 points) compared to controls (+1.75 points; p-value 0.05), it demonstrated significant associations with Learning problems (beta = 0.063, p = 0.005) and Anxiety scores (beta = 0.076, p = 0.003). Mediation analysis showed PSQ accounted for a large proportion of associations between prematurity and Conduct, Psychosomatic, Impulsive - hyperactive, and Hyperactivity problems (95% Bootstrap CI excluded 0). CONCLUSION: Premature infants may exhibit behavioral problems significantly associated with SDB, though our cross-sectional design precludes causal inference and parent-reported SDB severity may bias true associations. Future studies should utilize longitudinal cohorts to explore whether SDB is involved in the relationship between prematurity and behavioral problems (eg, anxiety). Additionally, they should conduct pilot randomized controlled trials of SDB interventions in preterm infants to assess neurodevelopmental benefits. Final conclusions require subsequent causal validation. CI - (c) 2025 Hu et al. FAU - Hu, Yuli AU - Hu Y AUID- ORCID: 0000-0003-3907-2952 AD - Nursing Department of Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Xuhui, Shanghai, 200233, People's Republic of China. AD - School of Nursing, Shanghai Jiaotong University, Shanghai, 200025, People's Republic of China. FAU - Jiang, Siqiong AU - Jiang S AD - Nursing Department of Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Xuhui, Shanghai, 200233, People's Republic of China. FAU - Yang, Shiyin AU - Yang S AD - Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, People's Republic of China. FAU - Wang, Chunsheng AU - Wang C AD - School of Medicine, Huzhou University, Zhejiang, 310000, People's Republic of China. FAU - Zou, Jianyin AU - Zou J AD - Department of Otolaryngology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, People's Republic of China. FAU - Guan, Jian AU - Guan J AD - Department of Otolaryngology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, People's Republic of China. FAU - Liu, Yupu AU - Liu Y AUID- ORCID: 0000-0003-0865-4669 AD - Department of Otolaryngology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, People's Republic of China. FAU - Lu, Qunfeng AU - Lu Q AD - Nursing Department of Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Xuhui, Shanghai, 200233, People's Republic of China. AD - School of Nursing, Shanghai Jiaotong University, Shanghai, 200025, People's Republic of China. LA - eng PT - Journal Article DEP - 20251008 PL - New Zealand TA - Nat Sci Sleep JT - Nature and science of sleep JID - 101537767 PMC - PMC12515976 OTO - NOTNLM OT - behavioral problems OT - premature birth OT - sleep-disordered breathing COIS- The authors declare no conflicts of interest. EDAT- 2025/10/15 06:29 MHDA- 2025/10/15 06:30 PMCR- 2025/10/08 CRDT- 2025/10/15 04:44 PHST- 2025/05/19 00:00 [received] PHST- 2025/09/04 00:00 [accepted] PHST- 2025/10/15 06:30 [medline] PHST- 2025/10/15 06:29 [pubmed] PHST- 2025/10/15 04:44 [entrez] PHST- 2025/10/08 00:00 [pmc-release] AID - 539617 [pii] AID - 10.2147/NSS.S539617 [doi] PST - epublish SO - Nat Sci Sleep. 2025 Oct 8;17:2599-2610. doi: 10.2147/NSS.S539617. eCollection 2025. PMID- 41085909 OWN - NLM STAT- MEDLINE DCOM- 20251014 LR - 20251017 IS - 2162-4968 (Electronic) IS - 2162-4968 (Linking) VI - 14 IP - 1 DP - 2025 Oct 14 TI - Intersection between Eating Disorders and Obesity in Youth: Implications for Treatment. PG - 71 LID - 10.1007/s13679-025-00664-6 [doi] LID - 71 AB - PURPOSE OF REVIEW: Eating disorders among children and adolescents occur in all body sizes and must be properly identified and treated across settings for optimal health outcomes. This review summarizes considerations for behavioral, pharmacological, and surgical obesity treatment and eating disorder risk. RECENT FINDINGS: Obesity and eating disorders share many common risk factors. Yet adolescents with obesity and eating disorders are underrepresented in research studies and often remain undiagnosed in medical practice despite presenting with more severe symptoms. There is evidence for reduction of subclinical disordered eating attitudes and behaviors in health behavior and lifestyle trials, with emerging evidence of reductions in subclinical disordered behaviors (i.e., loss of control eating) for patients who have undergone bariatric surgery. There is a paucity of eating disorder screening and monitoring data reported in pharmacological trials. Psychosocial outcomes, including subclinical eating disordered attitudes and behaviors, suicidality risk, and symptoms of depression and anxiety, should be continuously monitored prior to and throughout obesity treatment. There are several validated measures to detect symptoms of disordered eating among youth with higher weights. Early detection of eating disorder symptoms among obesity treatment-seeking youth is imperative to inform the course of comorbid treatment to occur simultaneously, sequentially, or within specialty care. Adolescents with obesity are at greater risk for engaging in disordered eating and related worsened mental and physical health outcomes compared to peers without obesity. It is vital to assess for eating disorder symptoms and presentation to inform timely treatment. CI - (c) 2025. The Author(s). FAU - Button, Alyssa M AU - Button AM AUID- ORCID: 0000-0003-1294-057X AD - Departments of Psychiatry & Pediatrics, Virginia Commonwealth University, Richmond, VA, USA. alyssa.button@vcuhealth.org. FAU - Persaud, Alicia AU - Persaud A AUID- ORCID: 0000-0001-9297-4520 AD - Public Health Sciences, Washington University in St. Louis, St. Louis, MO, USA. FAU - Tanner, Anna B AU - Tanner AB AUID- ORCID: 0000-0002-5251-0753 AD - School of Medicine, Emory University, Atlanta, GA, USA. FAU - Balantekin, Katherine N AU - Balantekin KN AUID- ORCID: 0000-0002-6760-2714 AD - Exercise and Nutrition Sciences, University at Buffalo SUNY, Buffalo, NY, USA. FAU - Tanofsky-Kraff, Marian AU - Tanofsky-Kraff M AUID- ORCID: 0000-0003-3871-2233 AD - Departments of Medical and Clinical Psychology & Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. FAU - Jebeile, Hiba AU - Jebeile H AUID- ORCID: 0000-0002-8623-6174 AD - University of Sydney, Children's Hospital Westmead Clinical School, NSW, Sydney, Australia. FAU - Wilfley, Denise E AU - Wilfley DE AUID- ORCID: 0000-0002-3599-8689 AD - Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA. wilfleyd@wustl.edu. LA - eng PT - Journal Article PT - Review DEP - 20251014 PL - United States TA - Curr Obes Rep JT - Current obesity reports JID - 101578283 SB - IM MH - Humans MH - *Feeding and Eating Disorders/therapy/psychology/diagnosis/complications/epidemiology MH - Adolescent MH - *Pediatric Obesity/therapy/psychology/epidemiology/complications MH - Bariatric Surgery MH - Child MH - Risk Factors MH - Health Behavior MH - Feeding Behavior PMC - PMC12521335 OTO - NOTNLM OT - Anti-obesity medication OT - Behavioral weight management OT - Lifestyle treatment OT - Metabolic and bariatric surgery OT - Pediatrics COIS- Declarations. Competing Interests: The authors declare no competing interests. Disclaimer: The opinions and assertions expressed herein are those of the authors and are not to be construed as reflecting the views of the Uniformed Services University or the United States Department of Defense. The project described was supported by Grant Number T32MH019960 from the National Institute of Mental Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Mental Health or the National Institutes of Health. Financial Disclosures: There was no external funder for this study. EDAT- 2025/10/14 12:29 MHDA- 2025/10/14 12:30 PMCR- 2025/10/14 CRDT- 2025/10/14 11:23 PHST- 2025/05/18 00:00 [received] PHST- 2025/09/25 00:00 [accepted] PHST- 2025/10/14 12:30 [medline] PHST- 2025/10/14 12:29 [pubmed] PHST- 2025/10/14 11:23 [entrez] PHST- 2025/10/14 00:00 [pmc-release] AID - 10.1007/s13679-025-00664-6 [pii] AID - 664 [pii] AID - 10.1007/s13679-025-00664-6 [doi] PST - epublish SO - Curr Obes Rep. 2025 Oct 14;14(1):71. doi: 10.1007/s13679-025-00664-6. PMID- 41081491 OWN - NLM STAT- MEDLINE DCOM- 20251202 LR - 20260531 IS - 1469-0705 (Electronic) IS - 0960-7692 (Linking) VI - 66 IP - 6 DP - 2025 Dec TI - Ultrasound-defined adenomyosis subtypes and their impact on outcomes following frozen embryo transfer: a propensity score-matched cohort study. PG - 786-794 LID - 10.1002/uog.70102 [doi] AB - OBJECTIVE: To evaluate the association of adenomyosis subtypes defined by ultrasound using the revised Morphological Uterus Sonographic Assessment (MUSA) criteria, with reproductive and obstetric outcomes following frozen embryo transfer (FET). METHODS: This retrospective, single-center cohort study included women who underwent their first FET cycle, as well as transvaginal ultrasound evaluation for the diagnosis of adenomyosis using the revised MUSA criteria, between August 2022 and June 2024. We included only FET cycles in which transferred embryos were of high quality. Adenomyosis subtypes were defined as follows: external (confined to the outer myometrium), internal (involving the inner myometrium, corresponding to the endometrial-myometrial junction, and/or the middle myometrium) and mixed (affecting both inner and outer myometrium). Controls were selected from women without ultrasound evidence of adenomyosis who underwent FET during the same period. Propensity score matching (1:1) was performed using patient age, body mass index, anti-Mullerian hormone level, infertility type, embryo stage, cause of infertility, FET protocol and number of embryos transferred. Comparative analyses were conducted to assess differences in reproductive and obstetric outcomes in women with adenomyosis, both overall and its subtypes, vs matched controls. The primary outcome was live birth, defined as delivery of at least one live infant at >/= 28 weeks' gestation. Secondary outcomes were: implantation, clinical pregnancy, ectopic pregnancy, early pregnancy loss (< 12 weeks), late pregnancy loss (12-28 weeks), multiple pregnancy, preterm birth (< 37 weeks), low birth weight (< 2500 g), fetal growth restriction, hypertensive disorders of pregnancy, gestational diabetes mellitus, placenta previa, placenta accreta, placental abruption, premature rupture of membranes and delivery by Cesarean section. RESULTS: Of 4146 eligible women, 879 with adenomyosis and 879 matched controls without adenomyosis were included in the analysis. Their age ranged from 20 to 42 years. The rate of live birth was significantly lower in the group with adenomyosis compared to controls (35.38% vs 45.16%, P < 0.001; odds ratio (OR), 0.67 (95% CI, 0.55-0.81)). Women with external adenomyosis, accounting for over 50% of cases, had a live-birth rate comparable with that of their matched controls (45.80% vs 46.85%, P = 0.795; OR, 0.96 (95% CI 0.74-1.24)), whereas the live-birth rate was significantly lower for women with internal adenomyosis (27.44% vs 42.33%, P = 0.002; OR, 0.52 (95% CI, 0.34-0.77)) and even lower for those with mixed-type adenomyosis (18.09% vs 44.15%, P < 0.001; OR, 0.28 (95% CI, 0.17-0.45)) compared with controls. The rate of early pregnancy loss was higher in adenomyosis patients compared with controls (22.25% vs 15.65% of clinical pregnancies, P = 0.011; OR, 1.54 (95% CI, 1.10-2.15)). There were no significant differences in most of the other secondary outcomes in women with a live birth, between those with adenomyosis and controls. However, subgroup analysis revealed several significant associations between adenomyosis phenotypes, mainly internal and mixed-type adenomyosis, and specific obstetric outcomes. CONCLUSIONS: Adenomyosis, particularly internal and mixed-type, is associated with a reduced live-birth rate and an increased risk of early pregnancy loss in those achieving clinical pregnancy following FET. Ultrasound-based phenotyping of adenomyosis prior to FET may support individualized assisted reproductive technology management. Further prospective studies are needed to validate these results. (c) 2025 International Society of Ultrasound in Obstetrics and Gynecology. CI - (c) 2025 International Society of Ultrasound in Obstetrics and Gynecology. FAU - Wang, L AU - Wang L AD - Center for Human Reproduction and Genetics, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China. FAU - Zheng, H AU - Zheng H AD - Center for Human Reproduction and Genetics, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China. FAU - Weng, C AU - Weng C AD - Center for Human Reproduction and Genetics, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China. FAU - Su, Q AU - Su Q AD - Center for Human Reproduction and Genetics, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China. FAU - Yang, F AU - Yang F AD - Center for Human Reproduction and Genetics, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China. FAU - Wang, F AU - Wang F AUID- ORCID: 0000-0001-7467-8074 AD - Center for Human Reproduction and Genetics, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China. LA - eng GR - SYW2024113/Suzhou Applied Basic Research (Healthcare) Youth Program/ GR - 2022YFC2702901/the National Key R&D Program of China/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251013 PL - England TA - Ultrasound Obstet Gynecol JT - Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology JID - 9108340 SB - IM MH - Humans MH - Female MH - *Adenomyosis/diagnostic imaging/classification/complications MH - Pregnancy MH - Retrospective Studies MH - *Embryo Transfer/methods/statistics & numerical data MH - Adult MH - Propensity Score MH - Ultrasonography/methods MH - Pregnancy Rate MH - Pregnancy Outcome MH - Uterus/diagnostic imaging MH - Infertility, Female/etiology/therapy MH - Cryopreservation MH - Myometrium/diagnostic imaging OTO - NOTNLM OT - IVF outcomes OT - MUSA criteria OT - adenomyosis OT - endometrial-myometrial junction OT - frozen embryo transfer EDAT- 2025/10/13 12:30 MHDA- 2025/12/02 19:15 CRDT- 2025/10/13 08:54 PHST- 2025/07/15 00:00 [revised] PHST- 2025/02/06 00:00 [received] PHST- 2025/08/13 00:00 [accepted] PHST- 2025/12/02 19:15 [medline] PHST- 2025/10/13 12:30 [pubmed] PHST- 2025/10/13 08:54 [entrez] AID - 10.1002/uog.70102 [doi] PST - ppublish SO - Ultrasound Obstet Gynecol. 2025 Dec;66(6):786-794. doi: 10.1002/uog.70102. Epub 2025 Oct 13. PMID- 41081020 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251013 LR - 20251015 IS - 1394-195X (Print) IS - 2180-4303 (Electronic) IS - 1394-195X (Linking) VI - 32 IP - 3 DP - 2025 Jun TI - A Two-Sample Analysis of the Construct Validity and Temporal Stability of a Process-Oriented Measure of Exercise Habit Strength. PG - 99-108 LID - 10.21315/mjms-03-2025-169 [doi] AB - BACKGROUND: The Exercise Habit Strength Questionnaire (EHSQ) has shown excellent psychometric properties. However, children in different weight categories exhibit distinct patterns of exercise engagement. Therefore, examining the EHSQ's psychometric properties across different weight groups across time may provide additional evidence of its discriminatory power and temporal stability. METHODS: This study was conducted in two samples. Sample 1 involved 450 secondary school students (mean age: 14.72 +/- 1.19 years), consisting of 52% males and 48% females across different body mass index (BMI) categories-normal (17.70%), overweight (23.44%), and obese (58.85%). Data collection involved the EHSQ, Body Appreciation Scale and the Implicit Association Test. Sample 2 consisted of 60 female students aged 16 years from all-girls schools, with 48.3% in the normal category and the remaining underweight, overweight, and obese categories. The EHSQ was administered twice, with a three-month interval between administrations. RESULTS: Confirmatory factor analysis provided evidence of factorial validity (chi (2) = 210.06, df = 129, P < 0.05; chi (2)/df = 1.63; CFI = 0.96; GFI = 0.95; RMSEA = 0.04; AIC = 314.69). Item loadings were above 0.5, except for one item, with latent factor intercorrelations ranging from 0.2 to 0.5. The results of the Intraclass correlation coefficient analysis demonstrated excellent test-retest reliability. Additionally, internal consistency scores in Sample 2 mirrored those of Sample 1, with Cronbach's alpha values of 0.756 for patterned action, 0.757 for automaticity, 0.89 for negative consequences, and 0.84 for stimulus cue. CONCLUSION: Overall, the results provided adequate support for the hypothesised psychometric properties of the ESHQ. CI - (c) Penerbit Universiti Sains Malaysia, 2025. FAU - Hashim, Hairul Anuar AU - Hashim HA AD - School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kelantan, Malaysia. FAU - Noordin, Nur Hidayah AU - Noordin NH AD - Faculty of Health and Life Sciences, Management and Science University, Selangor, Malaysia. FAU - Syed Ahmad, Syed Husin AU - Syed Ahmad SH AD - Faculty of Health and Life Sciences, Management and Science University, Selangor, Malaysia. FAU - Ishak, Asmadi AU - Ishak A AD - Faculty of Sport Science and Coaching, Universiti Pendidikan Sultan Idris, Perak, Malaysia. FAU - Othman, Azizah AU - Othman A AD - School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kelantan, Malaysia. LA - eng PT - Journal Article DEP - 20250630 PL - Malaysia TA - Malays J Med Sci JT - The Malaysian journal of medical sciences : MJMS JID - 101126308 PMC - PMC12513516 OTO - NOTNLM OT - adolescents OT - exercise habit OT - intraclass correlation coefficient OT - obesity OT - psychometric properties COIS- Conflict of Interest: None. EDAT- 2025/10/13 12:31 MHDA- 2025/10/13 12:32 PMCR- 2025/06/01 CRDT- 2025/10/13 07:41 PHST- 2025/03/06 00:00 [received] PHST- 2025/05/01 00:00 [accepted] PHST- 2025/10/13 12:32 [medline] PHST- 2025/10/13 12:31 [pubmed] PHST- 2025/10/13 07:41 [entrez] PHST- 2025/06/01 00:00 [pmc-release] AID - 07mjms3203_oa [pii] AID - 10.21315/mjms-03-2025-169 [doi] PST - ppublish SO - Malays J Med Sci. 2025 Jun;32(3):99-108. doi: 10.21315/mjms-03-2025-169. Epub 2025 Jun 30. PMID- 41080088 OWN - NLM STAT- MEDLINE DCOM- 20251013 LR - 20251015 IS - 1661-8564 (Electronic) IS - 1661-8556 (Print) IS - 1661-8556 (Linking) VI - 70 DP - 2025 TI - Sex Based Comparison of Health Self-Perception, Sleep, Anxiety, and Body Composition Among University Students. PG - 1608551 LID - 10.3389/ijph.2025.1608551 [doi] LID - 1608551 AB - OBJECTIVES: Health self-perception (HSP) refers to an individual's subjective evaluation of their overall health, encompassing both physical and psychological dimensions. A number of factors, such as body composition, anxiety levels, and sleep quality, can have an impact on HSP among university students. There is a limited research investigating the combined association between HSP, sleep quality, and anxiety status in this demographic, despite the fact that each of these characteristics has been examined separately in relation to students' health. Furthermore, students' perceptions and reporting of their health may be influenced by contextual and cultural factors, particularly in the United Arab Emirates (UAE). This study aimed to explore the association of HSP with anthropometric measurements, sleep quality, and anxiety status and to compare these associations between female and male university students. METHODS: This cross-sectional study recruited 390 university students (198 males and 192 females), aged 18-25 years. A validated questionnaire was used for determining the sleep quality, anxiety and HSP while body composition was measured by using body analyzer. RESULTS: Majority (59%) of the students reported positive HSP which was significantly associated with higher sleep quality and lower state anxiety scores compared to negative HSP group. Females were more likely to have negative HSP compared to males (p < 0.001). Moreover, the State-Trait Anxiety Inventory (STAI) score, PBF, FM, and VFR were significantly lower while sleep quality score and FFM were significantly higher among positive HSP group. CONCLUSION: This study highlighted that good sleep quality, low anxiety levels, and healthy body composition are correlated with positive HSP and were significantly dependent on sex. A comprehensive health program is essential to improve sleep quality and anxiety status to promote good HSP among university students. CI - Copyright (c) 2025 Basheer, Radwan, Raigangar, Zeb, Zamrik, Adi, Faraj, Chaker, Osaili and Hasan. FAU - Basheer, Sondos AU - Basheer S AD - Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. FAU - Radwan, Hadia AU - Radwan H AD - Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. AD - Nutrition and Food Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. FAU - Raigangar, Veena AU - Raigangar V AD - School of Sport and Health Sciences, University of Brighton, Brighton, United Kingdom. FAU - Zeb, Falak AU - Zeb F AD - Nutrition and Food Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. FAU - Zamrik, Ayat AU - Zamrik A AD - Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. FAU - Adi, Raghda AU - Adi R AD - Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. FAU - Faraj, Tala AU - Faraj T AD - Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. FAU - Chaker, Woroud AU - Chaker W AD - Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. FAU - Osaili, Tareq AU - Osaili T AD - Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. AD - Nutrition and Food Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. AD - Department of Nutrition and Food Technology, Faculty of Agriculture, University of Science and Technology, Irbid, Jordan. FAU - Hasan, Hayder AU - Hasan H AD - Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. AD - Nutrition and Food Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. LA - eng PT - Comparative Study PT - Journal Article DEP - 20250926 PL - Switzerland TA - Int J Public Health JT - International journal of public health JID - 101304551 SB - IM MH - Humans MH - Female MH - Male MH - *Students/psychology/statistics & numerical data MH - Cross-Sectional Studies MH - *Anxiety/epidemiology/psychology MH - Young Adult MH - Universities MH - Adolescent MH - Adult MH - *Body Composition MH - Sex Factors MH - *Self Concept MH - *Sleep Quality MH - United Arab Emirates/epidemiology MH - *Sleep MH - Surveys and Questionnaires MH - Health Status PMC - PMC12510905 OTO - NOTNLM OT - anxiety OT - body composition indicators OT - health self-perception OT - self-rated health OT - sleep quality COIS- The authors declare that they do not have any conflicts of interest. EDAT- 2025/10/13 12:31 MHDA- 2025/10/13 12:32 PMCR- 2025/09/26 CRDT- 2025/10/13 07:32 PHST- 2025/03/26 00:00 [received] PHST- 2025/08/21 00:00 [accepted] PHST- 2025/10/13 12:32 [medline] PHST- 2025/10/13 12:31 [pubmed] PHST- 2025/10/13 07:32 [entrez] PHST- 2025/09/26 00:00 [pmc-release] AID - 1608551 [pii] AID - 10.3389/ijph.2025.1608551 [doi] PST - epublish SO - Int J Public Health. 2025 Sep 26;70:1608551. doi: 10.3389/ijph.2025.1608551. eCollection 2025. PMID- 41079860 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251013 LR - 20251015 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 16 DP - 2025 TI - Effect of cognitive bias modification training on body image dissatisfaction in adolescents with anorexia nervosa or depression-a pilot feasibility randomized controlled crossover study. PG - 1655064 LID - 10.3389/fpsyg.2025.1655064 [doi] LID - 1655064 AB - INTRODUCTION: Body image disturbance presents transdiagnostically with an impact on the development and maintenance of psychiatric disorders. Addressing body image disturbance, a cognitive bias modification training (CBM) was developed using a two-alternative forced choice task (2-AFC) to alter patients' individual perceptual boundary between what they classify as a fat versus a thin body. This pilot study aimed to evaluate, for the first time, the paradigm's feasibility and efficacy in adolescents in a clinical context. METHODS: This pilot study included adolescent inpatients aged 13-17 years diagnosed with (atypical) anorexia nervosa (n = 12) or depression (n = 17), representing two prevalent disorders in adolescence. The 2-AFC task was tested in this population for the first time. Designed as a randomized crossover trial, patients underwent a 4-day intervention with corrective feedback and a 4-day control with confirmatory feedback. Psychometric measures assessing body image disturbance, depressive symptoms, and general psychopathology were collected at the beginning of the training and 10 days afterward (day 1, 15, 29). RESULTS: Mixed ANOVAs showed that the 2-AFC CBM paradigm significantly shifted the categorical boundary over 10 days, altering patients' individual perceptual boundary but did not improve the body image specific psychometric measures. Linear regression indicated training effects on diagnosis-specific characteristics, and t-test comparisons revealed improved depression-specific symptoms for the depression group. The control condition had a non-neutral effect and shifted the individual boundary to a lower body mass index (BMI), particularly in patients with anorexia. DISCUSSION: These findings confirm the feasibility and effectiveness of the 2-AFC CBM paradigm in adolescent inpatients transdiagnostically with further larger randomized controlled effectiveness trials required. The study suggests including normal-weight patients with anorexia nervosa only and not using confirmatory feedback as a control condition, but as an orientation and confirmation of a healthy weight limit. CI - Copyright (c) 2025 Glombitza, Cornelissen, Tovee and Legenbauer. FAU - Glombitza, Eva AU - Glombitza E AD - Faculty of Medicine, Ruhr University Bochum, Bochum, Germany. AD - LWL University Hospital for Child and Adolescent Psychiatry, Medical Faculty, Ruhr University Bochum, Bochum, Germany. FAU - Cornelissen, Piers L AU - Cornelissen PL AD - Department of Psychology, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom. FAU - Tovee, Martin J AU - Tovee MJ AD - Department of Psychology, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom. FAU - Legenbauer, Tanja AU - Legenbauer T AD - Faculty of Medicine, Ruhr University Bochum, Bochum, Germany. AD - LWL University Hospital for Child and Adolescent Psychiatry, Medical Faculty, Ruhr University Bochum, Bochum, Germany. LA - eng PT - Journal Article DEP - 20250926 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC12510976 OTO - NOTNLM OT - adolescents OT - anorexia nervosa OT - body image dissatisfaction OT - cognitive bias modification OT - depression COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/10/13 12:31 MHDA- 2025/10/13 12:32 PMCR- 2025/09/26 CRDT- 2025/10/13 07:30 PHST- 2025/06/27 00:00 [received] PHST- 2025/08/27 00:00 [accepted] PHST- 2025/10/13 12:32 [medline] PHST- 2025/10/13 12:31 [pubmed] PHST- 2025/10/13 07:30 [entrez] PHST- 2025/09/26 00:00 [pmc-release] AID - 10.3389/fpsyg.2025.1655064 [doi] PST - epublish SO - Front Psychol. 2025 Sep 26;16:1655064. doi: 10.3389/fpsyg.2025.1655064. eCollection 2025. PMID- 41079200 OWN - NLM STAT- MEDLINE DCOM- 20260227 LR - 20260227 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 16 DP - 2025 TI - Obesity metabolomics signature in children: associations with metabolic abnormalities and potential biomarkers. PG - 1671613 LID - 10.3389/fendo.2025.1671613 [doi] LID - 1671613 AB - BACKGROUND: The global rise in childhood obesity has heightened its recognition as a major public health concern, with obesity being an independent risk factor for metabolic abnormalities. However, the metabolomics mechanisms linking pediatric obesity to metabolic abnormalities remain unclear. METHODS: This case-control study utilized data from a 2023 cross-sectional survey of children aged 9-18 years in Guangzhou, China. A total of 246 participants were included, with 123 obese and 123 normal-weight participants matched for age and sex. Serum metabolomics profiling was performed via LC-MS. A dual machine learning approach combining penalized multivariable Least Absolute Shrinkage and Selection Operator (LASSO) regression and random forest with recursive feature elimination (RF-RFE) was employed to identify robust obesity-associated serum metabolites independent of metabolic abnormalities and logistic regression was employed to construct the obesity metabolomics signature (OB-MS) model. Multivariable logistic regression was used to assess the associations between the OB-MS and metabolic abnormalities and their components, including hyperglycemia, hypertension, hypertriglyceridemia, and reduced HDL-C. RESULTS: Among 934 detected metabolites, 10 core metabolites were selected to construct the OB-MS, which showed high discriminative power, with an ROC-AUC of 0.986 in the testing set. Elevated OB-MS scores were significantly associated with increased risks of metabolic abnormalities, particularly hypertension and hypertriglyceridemia. Additionally, six key metabolites, including oxidative stress markers and dipeptides, were independently associated with metabolic abnormalities. CONCLUSIONS: This study established a pediatric obesity-specific metabolomics signature (OB-MS), implicating oxidative stress, protein catabolism, and glucocorticoid metabolism in obesity-related metabolic abnormalities. These finding illustrate the metabolic mechanisms underlying the relationship between childhood obesity and metabolic abnormalities and provide new scientific support for early and precise prevention of metabolic abnormalities in children. Further longitudinal studies and experimental validation are warranted to elucidate its biological mechanisms and clinical utility. CI - Copyright (c) 2025 Wan, Luo, Zhong, Tao, Guo, Zeng, Peng, Zhang, Zhang, Gu, Huang and Li. FAU - Wan, Jiayi AU - Wan J AD - School of Public Health, Sun Yat-sen University, Guangzhou, China. AD - Guangzhou Center for Disease Control and Prevention, Guangzhou Health Supervision Institute, Guangzhou, China. FAU - Luo, Shiyun AU - Luo S AD - Guangzhou Center for Disease Control and Prevention, Guangzhou Health Supervision Institute, Guangzhou, China. FAU - Zhong, Wanzhen AU - Zhong W AD - School of Public Health, Sun Yat-sen University, Guangzhou, China. AD - Guangzhou Center for Disease Control and Prevention, Guangzhou Health Supervision Institute, Guangzhou, China. FAU - Tao, Guixian AU - Tao G AD - School of Public Health, Sun Yat-sen University, Guangzhou, China. AD - Guangzhou Center for Disease Control and Prevention, Guangzhou Health Supervision Institute, Guangzhou, China. FAU - Guo, Jiaying AU - Guo J AD - School of Public Health, Sun Yat-sen University, Guangzhou, China. AD - Guangzhou Center for Disease Control and Prevention, Guangzhou Health Supervision Institute, Guangzhou, China. FAU - Zeng, Chunzi AU - Zeng C AD - Guangzhou Center for Disease Control and Prevention, Guangzhou Health Supervision Institute, Guangzhou, China. FAU - Peng, Yujie AU - Peng Y AD - Guangzhou Center for Disease Control and Prevention, Guangzhou Health Supervision Institute, Guangzhou, China. FAU - Zhang, Weiwei AU - Zhang W AD - Guangzhou Center for Disease Control and Prevention, Guangzhou Health Supervision Institute, Guangzhou, China. FAU - Zhang, Zhoubin AU - Zhang Z AD - Guangzhou Center for Disease Control and Prevention, Guangzhou Health Supervision Institute, Guangzhou, China. FAU - Gu, Jing AU - Gu J AD - School of Public Health, Sun Yat-sen University, Guangzhou, China. FAU - Huang, Jie AU - Huang J AD - Guangzhou Center for Disease Control and Prevention, Guangzhou Health Supervision Institute, Guangzhou, China. FAU - Li, Yan AU - Li Y AD - Guangzhou Center for Disease Control and Prevention, Guangzhou Health Supervision Institute, Guangzhou, China. AD - School of Public Health, Sun Yat-sen University, Guangzhou, China. LA - eng PT - Journal Article DEP - 20250925 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Biomarkers) RN - 0 (Glucocorticoids) SB - IM MH - Metabolomics/methods MH - *Pediatric Obesity/blood/epidemiology/metabolism MH - *Metabolome MH - Biomarkers/blood/metabolism MH - *Metabolic Diseases/blood/diagnosis/epidemiology/metabolism MH - Risk Factors MH - Case-Control Studies MH - Cross-Sectional Studies MH - China/epidemiology MH - Machine Learning MH - Hyperglycemia/blood/diagnosis/epidemiology/metabolism MH - Hypertension/blood/diagnosis/epidemiology/metabolism MH - Hypertriglyceridemia/blood/diagnosis/epidemiology/metabolism MH - Oxidative Stress MH - Glucocorticoids/metabolism MH - Humans MH - Male MH - Female MH - Child MH - Adolescent PMC - PMC12507617 OTO - NOTNLM OT - children OT - metabolic abnormalities OT - metabolomics OT - obesity OT - oxidative stress COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/10/13 12:30 MHDA- 2025/10/13 12:31 PMCR- 2025/09/25 CRDT- 2025/10/13 07:23 PHST- 2025/07/23 00:00 [received] PHST- 2025/09/15 00:00 [accepted] PHST- 2025/10/13 12:31 [medline] PHST- 2025/10/13 12:30 [pubmed] PHST- 2025/10/13 07:23 [entrez] PHST- 2025/09/25 00:00 [pmc-release] AID - 10.3389/fendo.2025.1671613 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2025 Sep 25;16:1671613. doi: 10.3389/fendo.2025.1671613. eCollection 2025. PMID- 41079021 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251013 LR - 20251015 IS - 2589-5370 (Electronic) IS - 2589-5370 (Linking) VI - 89 DP - 2025 Nov TI - Using artificial intelligence and computer vision to detect and monitor unhealthy child-directed food and beverage marketing: a data-driven study. PG - 103549 LID - 10.1016/j.eclinm.2025.103549 [doi] LID - 103549 AB - BACKGROUND: Childhood obesity and diet-related noncommunicable diseases are urgent global public health challenges, driven in part by children's continued exposure to persuasive marketing of unhealthy foods and beverages. Traditional methods that manually evaluate child-targeted food marketing practices are resource-intensive and inefficient. This study aims to address these limitations by leveraging artificial intelligence (AI), specifically computer vision and deep learning, to identify child-targeted food products and classify marketing elements on food packaging using a comprehensive database labeled with child-directed marketing features. Additionally, this study explores the practical application of AI within a specific food category to examine the relationships between child-directed marketing features, nutrition quality, and price, to estimate the potential impact of proposed Canadian marketing-to-children regulations. METHODS: Image classification algorithms were trained on 8283 manually labeled food package images, annotated and validated between 2021 and 2024 using a validated child-appealing packaging (CAP) coding tool. This labeled dataset served as the ground truth for model training and evaluation. Three machine learning algorithms, k-nearest neighbors (kNN), support vector machines (SVM), and convolutional neural networks (CNN) were used to classify food package images targeted at children. In addition, latest image object detection model, YOLOv12 (released February 2025), were fine-tuned to identify specific child-targeted marketing features on food and beverage packaging. Model performance was evaluated using accuracy, precision, recall, F1 score, AUC, and confusion matrix. We applied this AI strategy to breakfast cereals (n = 1765) to assess the proportion of food products displaying child-directed marketing features and that would be restricted under Canadian proposed marketing-to-children regulations, and conducted regression analysis to investigate the relationship between food marketing features and food price. FINDINGS: A total of 22 distinct child-directed marketing techniques featured on food and beverage packages were identified and annotated. The CNN-based image classification model outperformed kNN and SVM, achieving 0.90 accuracy and 0.96 AUC in identifying food marketing targeted at children against manually coded labels. Fine-tuned YOLOv12 object detection model demonstrated varying performance levels across child-targeted marketing features, reflecting the complexity and diversity of marketing strategies on food packaging. By applying this AI strategy, 39.2% of breakfast cereals were found to display child-directed marketing features, of which 89.5% would be considered as unhealthy and restricted under Canadian proposed marketing-to-children regulations. Products with child-directed marketing features showed a negative, but not statistically significant, association with price (coefficient = -0.25, p = 0.072). INTERPRETATION: This study introduces the first AI-driven approach to effectively identify and categorize child-directed marketing on food and beverage packaging. These methods offer a scalable and efficient AI-driven solution for monitoring compliance with marketing-to-children policies and evaluating associations with nutrition quality and price, and can be extended to other data sources such as social media and online video content for broader applications. This study supports evidence-based policy development to protect children from unhealthy food marketing practices and provides critical insights into its potential impacts on children's health outcomes. FUNDING: This work was funded by the Data Sciences Institute catalyst grants, Health Canada research contract on M2K research, and the CIHR project grants. CI - (c) 2025 The Authors. FAU - Hu, Guanlan AU - Hu G AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, ON, Canada. AD - Data Sciences Institute, Columbia University, NY, USA. FAU - Gross, Ofek AU - Gross O AD - Department of Computer Science, University of Toronto, ON, Canada. FAU - Ziraldo, Emily AU - Ziraldo E AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, ON, Canada. FAU - Mulligan, Christine AU - Mulligan C AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, ON, Canada. AD - Department of Community Health Sciences, University of Calgary, AB, Canada. FAU - Soberman, David AU - Soberman D AD - Marketing, Rotman School of Management, University of Toronto, ON, Canada. FAU - Dewan, Moesha AU - Dewan M AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, ON, Canada. FAU - Lewis, Kyana AU - Lewis K AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, ON, Canada. FAU - Nomani, Raneem AU - Nomani R AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, ON, Canada. AD - Honours Life Sciences Program, McMaster University, ON, Canada. FAU - Lu, August AU - Lu A AD - Department of Computer Science, University of Toronto, ON, Canada. FAU - L'Abbe, Mary R AU - L'Abbe MR AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, ON, Canada. LA - eng PT - Journal Article DEP - 20250930 PL - England TA - EClinicalMedicine JT - EClinicalMedicine JID - 101733727 PMC - PMC12513061 OTO - NOTNLM OT - Artificial intelligence OT - Childhood obesity OT - Image classification OT - Image object detection OT - Unhealthy food marketing to children COIS- M.L. reports research funding, travel support, licensing fees, and unpaid leadership or advisory roles. She declares no other competing interests. All other authors declare no competing interests. EDAT- 2025/10/13 18:10 MHDA- 2025/10/13 18:11 PMCR- 2025/09/30 CRDT- 2025/10/13 07:21 PHST- 2025/04/24 00:00 [received] PHST- 2025/08/19 00:00 [revised] PHST- 2025/09/16 00:00 [accepted] PHST- 2025/10/13 18:11 [medline] PHST- 2025/10/13 18:10 [pubmed] PHST- 2025/10/13 07:21 [entrez] PHST- 2025/09/30 00:00 [pmc-release] AID - S2589-5370(25)00482-1 [pii] AID - 103549 [pii] AID - 10.1016/j.eclinm.2025.103549 [doi] PST - epublish SO - EClinicalMedicine. 2025 Sep 30;89:103549. doi: 10.1016/j.eclinm.2025.103549. eCollection 2025 Nov. PMID- 41078463 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251013 LR - 20251015 IS - 2279-9028 (Print) IS - 2279-9036 (Electronic) IS - 2279-9028 (Linking) VI - 14 IP - 4 DP - 2025 Oct TI - Translation and validation of health professionals' knowledge and attitudes instrument regarding Baby-Led Weaning approach into European Portuguese. PG - 22799036251369405 LID - 10.1177/22799036251369405 [doi] LID - 22799036251369405 AB - BACKGROUND: Early childhood is a critical period for preventing malnutrition and ensuring adequate nutrient intake. While various feeding approaches exist, no consensus has been reached on the ideal one. Baby-Led Weaning (BLW) is an emerging method that involves the direct introduction of finger foods to children. However, limited evidence exists on health professionals' (HP) perspective. We aim to translate and validate an instrument to assess the knowledge and attitudes of HP toward BLW method in European Portuguese. DESIGN AND METHODS: A methodological study was conducted with a nonprobability sample of 118 HPs working in primary care settings. The instrument underwent translation, back-translation, and review by an expert panel to ensure semantic and conceptual equivalence. The content validity index (CVI) and exploratory factor analysis (EFA) were employed to assess content and construct validity, respectively. Internal consistency was measured using Cronbach's alpha. The instrument was available online. RESULTS: The adapted instrument showed high content validity, with CVI values of 0.89 for practice-related items and 0.87 for knowledge and attitude items. EFA revealed three distinct factors: positive child-centered contributions, positive parent-centered contributions, and BLW constraints, explaining 67.46% of total variance. The model's suitability was confirmed by Bartlett's test of sphericity (chi(2)(66) = 665.735; p < 0.001) and the KMO index (0.829). All dimensions demonstrated good internal consistency (Cronbach's alpha > 0.7). CONCLUSIONS: The validated instrument is a reliable tool for assessing HPs' knowledge and attitudes toward BLW. Findings support the need for targeted education to better equip professionals in guiding parents on BLW practices. CI - (c) The Author(s) 2025. FAU - Sarreira-de-Oliveira, Paula AU - Sarreira-de-Oliveira P AUID- ORCID: 0000-0002-2812-9565 AD - Egas Moniz School of Health and Science, Egas Moniz Center for Interdisciplinary Research, (CiiEM), Campus Universitario, Quinta da Granja, Monte de Caparica, Caparica, Portugal. FAU - Ramalho, Renata AU - Ramalho R AUID- ORCID: 0000-0003-1175-1400 AD - Egas Moniz School of Health and Science, Nutritional Immunology - Clinical and Experimental Lab (NICE Lab), Clinical Research Unit, Egas Moniz Center for Interdisciplinary Research (CiiEM), Campus Universitario, Quinta da Granja, Monte de Caparica, Caparica, Portugal. FAU - Antunes, Ricardo AU - Antunes R AUID- ORCID: 0000-0003-4771-3975 AD - Egas Moniz School of Health and Science, Egas Moniz Center for Interdisciplinary Research (CiiEM), Campus Universitario, Quinta da Granja, Monte de Caparica, Caparica, Portugal. FAU - Loureiro, Fernanda AU - Loureiro F AUID- ORCID: 0000-0002-5600-2422 AD - Universidade Catolica Portuguesa, Faculdade de Ciencias da Saude e Enfermagem, Centro de Investigacao Interdisciplinar em Saude (CIIS), Palma de Cima, Lisboa, Portugal. LA - eng PT - Journal Article DEP - 20251008 PL - United States TA - J Public Health Res JT - Journal of public health research JID - 101580775 PMC - PMC12511716 OTO - NOTNLM OT - Baby-Led Weaning OT - attitudes OT - health care professional OT - infant nutrition OT - knowledge COIS- The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/10/13 12:31 MHDA- 2025/10/13 12:32 PMCR- 2025/10/08 CRDT- 2025/10/13 07:15 PHST- 2024/12/23 00:00 [received] PHST- 2025/07/29 00:00 [accepted] PHST- 2025/10/13 12:32 [medline] PHST- 2025/10/13 12:31 [pubmed] PHST- 2025/10/13 07:15 [entrez] PHST- 2025/10/08 00:00 [pmc-release] AID - 10.1177_22799036251369405 [pii] AID - 10.1177/22799036251369405 [doi] PST - epublish SO - J Public Health Res. 2025 Oct 8;14(4):22799036251369405. doi: 10.1177/22799036251369405. eCollection 2025 Oct. PMID- 41077073 OWN - NLM STAT- MEDLINE DCOM- 20251207 LR - 20260518 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 217 DP - 2026 Feb 1 TI - Feeding practices and concerns as mediators between maternal mental health and eating behaviours in early childhood. PG - 108340 LID - S0195-6663(25)00493-3 [pii] LID - 10.1016/j.appet.2025.108340 [doi] AB - BACKGROUND: The impact of maternal mental health on child eating beyond infancy is understudied. This study explores whether maternal feeding practices and concerns mediate the association between maternal depression and anxiety symptoms and eating behaviours at age three years. METHODS: Data from 409 mother-child dyads in the Growing Up in Singapore Towards healthy Outcomes cohort were analysed. Maternal mental health was assessed using the Beck Depression Inventory-II and State-Trait Anxiety Inventory, feeding practices and concerns with the Preschooler Feeding Questionnaire, and child eating behaviours with the Children's Eating Behaviour Questionnaire. Structural equation modelling was used to test pathways. RESULTS: Depression symptoms in mothers showed direct and indirect links to child eating behaviours. For example, maternal depression symptoms were directly associated with enjoyment of food (B = 0.011, p = 0.015) and indirectly with food responsiveness (B = 0.004, p = 0.034) via use of food to calm the child. Anxiety symptoms, however, had only indirect associations with child eating behaviours through maternal feeding concerns, not practices. For example, maternal anxiety symptoms were indirectly linked with food responsiveness through perceived difficulty in feeding (B = -0.001, p = 0.011). CONCLUSIONS: Depression and anxiety symptoms influence children's eating behaviours differently. Anxiety symptoms were linked with child eating behaviours only through maternal feeding concerns, whereas depression symptoms were linked with child eating behaviours both directly and indirectly via feeding to calm the child. As maternal anxiety symptoms are linked with more child eating concerns, the validity of mother-reported child eating behaviours requires consideration. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - Lazarus, Monica A AU - Lazarus MA AD - Human Potential Translational Research Program, Yong Loo Lin School of Medicine, Singapore, Republic of Singapore. FAU - Franzolini, Beatrice AU - Franzolini B AD - Institute for Data Science and Analytics, Bocconi University, Italy. FAU - Eriksson, Johan G AU - Eriksson JG AD - Human Potential Translational Research Program, Yong Loo Lin School of Medicine, Singapore, Republic of Singapore; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A *STAR), Singapore, Republic of Singapore; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore. FAU - Chong, Mary F-F AU - Chong MF AD - Saw Swee Hock School of Public Health, National University of Singapore, 12 Science Drive 2, #09-01Q, 117549, Republic of Singapore. FAU - Ying, Toh Jia AU - Ying TJ AD - Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A *STAR), Singapore, Republic of Singapore. FAU - de Iorio, Maria AU - de Iorio M AD - Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A *STAR), Singapore, Republic of Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, NUS, Republic of Singapore. FAU - Meaney, Michael J AU - Meaney MJ AD - Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A *STAR), Singapore, Republic of Singapore; Department of Psychiatry, Faculty of Medicine, Douglas Mental Health University Institute, Montreal, Canada. FAU - Godfrey, Keith M AU - Godfrey KM AD - MRC Lifecourse Epidemiology Centre and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. FAU - Yap, Fabian AU - Yap F AD - Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Republic of Singapore; Duke-NUS Medical School, Singapore, Republic of Singapore. FAU - Chen, Helen AU - Chen H AD - Department of Psychological Medicine, KK Women's and Children's Hospital, Republic of Singapore; Duke-National University of Singapore Graduate Medical School, Republic of Singapore. FAU - Chong, Yap Seng AU - Chong YS AD - Human Potential Translational Research Program, Yong Loo Lin School of Medicine, Singapore, Republic of Singapore; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A *STAR), Singapore, Republic of Singapore; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore. FAU - Kee, Michelle Z L AU - Kee MZL AD - Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A *STAR), Singapore, Republic of Singapore. FAU - Fogel, Anna M AU - Fogel AM AD - Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A *STAR), Singapore, Republic of Singapore. Electronic address: anna_fogel@a-star.edu.sg. LA - eng SI - ClinicalTrials.gov/NCT01174875 PT - Journal Article DEP - 20251010 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - *Feeding Behavior/psychology MH - Child, Preschool MH - Singapore MH - *Mothers/psychology MH - Anxiety/psychology MH - Male MH - Adult MH - *Depression/psychology MH - *Mother-Child Relations/psychology MH - *Child Behavior/psychology MH - Surveys and Questionnaires MH - *Mental Health MH - *Maternal Behavior/psychology OTO - NOTNLM OT - Appetite OT - Depression OT - Eating behaviours OT - Feeding practices OT - Mental health COIS- Declaration of competing interest KMG is supported by the UK Medical Research Council (MC_UU_12011/4), the National Institute for Health and Care Research (NIHR Senior Investigator (NF-SI-0515-10042) and NIHR Southampton Biomedical Research Centre (NIHR203319)) and the Rosetrees Foundation. For Open Access, the author has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising from this submission. KMG and YSC report being part of an academic consortium that has received research funding from Abbott Nutrition, Nestle and Danone. All other authors declare no competing financial or personal interests that could influence the work reported in this manuscript. The funding bodies had no role in the study design; collection, analysis, or interpretation of data; writing of the report; or decision to submit the article for publication. EDAT- 2025/10/13 00:27 MHDA- 2025/12/08 01:36 CRDT- 2025/10/12 19:30 PHST- 2025/07/20 00:00 [received] PHST- 2025/09/26 00:00 [revised] PHST- 2025/10/08 00:00 [accepted] PHST- 2025/12/08 01:36 [medline] PHST- 2025/10/13 00:27 [pubmed] PHST- 2025/10/12 19:30 [entrez] AID - S0195-6663(25)00493-3 [pii] AID - 10.1016/j.appet.2025.108340 [doi] PST - ppublish SO - Appetite. 2026 Feb 1;217:108340. doi: 10.1016/j.appet.2025.108340. Epub 2025 Oct 10. PMID- 41076748 OWN - NLM STAT- MEDLINE DCOM- 20251116 LR - 20260731 IS - 1878-5506 (Electronic) IS - 1389-9457 (Linking) VI - 136 DP - 2025 Dec TI - Infant sleep time: A comparative analysis of assessment methods. PG - 106838 LID - S1389-9457(25)00513-1 [pii] LID - 10.1016/j.sleep.2025.106838 [doi] AB - Understanding sleep functions in early development remains challenging due to limitations in the available measurement methods. This study aims to provide a comprehensive description of night and day sleep patterns of Italian infants and toddlers between 5 and 25 months of age while evaluating the accuracy, reliability, and practicality of commonly used sleep assessment tools such as actigraphy, diaries, and questionnaires. From a methodological viewpoint, an exhaustive cross-method validation approach suggested that actigraphy represents a valuable and practical tool for assessing infant sleep. However, its use should be approached with caution in contexts where sleep-wake differentiation is less distinct, for instance when motor activity is recurrent during sleep or naps. In such cases, validation against other methods is recommended to ensure reliable outcomes; expert manual coding and environmental audio recordings might be appropriate, when available. Lowering the sensitivity threshold in actigraphy and integrating parental reports also offer viable approaches to enhancing data reliability. Next, following best practices, infants and toddlers sleep duration was estimated. In our cohort, participants typically took one or two naps per day, with total daytime sleep ranging from 56 min to 2.58 h. On average, overnight sleep lasted 8 h, with approximately 2 night-awakenings, totaling between 35 min and 1.65 h. Overnight sleep in this sample appears slightly lower than what has been reported in infants of similar ages from other geographical contexts. This highlights the importance of considering sociocultural and ecological variability in pediatric sleep research and cautions against applying universal sleep conventions without contextual and methodological validation. CI - Copyright (c) 2025 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Bastianello, Tamara AU - Bastianello T AD - Department of Developmental Psychology and Socialisation, University of Padova, Padova, 35131, Italy. Electronic address: tamara.bastianello@unipd.it. FAU - Nascimben, Chiara AU - Nascimben C AD - Department of Developmental Psychology and Socialisation, University of Padova, Padova, 35131, Italy. Electronic address: chiara.nascimben.1@phd.unipd.it. FAU - Loschiavo, Adriana Grazia-Maria Angelina AU - Loschiavo AGA AD - Department of Developmental Psychology and Socialisation, University of Padova, Padova, 35131, Italy. Electronic address: adrianagraziamariaangelinaloschiavo@studenti.unipd.it. FAU - Reoyo-Serrano, Natalia AU - Reoyo-Serrano N AD - Department of Developmental Psychology and Socialisation, University of Padova, Padova, 35131, Italy. Electronic address: natalia.reoyoserrano@unipd.it. FAU - Dassie, Francesca AU - Dassie F AD - Department of Medicine, University of Padova, Padova, 35131, Italy. Electronic address: francesca.dassie@unipd.it. FAU - Benavides-Varela, Silvia AU - Benavides-Varela S AD - Department of Developmental Psychology and Socialisation, University of Padova, Padova, 35131, Italy; Padova Neuroscience Center, University of Padova, Padova, 35131, Italy. Electronic address: silvia.benavidesvarela@unipd.it. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250929 PL - Netherlands TA - Sleep Med JT - Sleep medicine JID - 100898759 SB - IM MH - Humans MH - Infant MH - *Actigraphy/methods MH - *Sleep/physiology MH - Reproducibility of Results MH - Child, Preschool MH - Male MH - Female MH - Surveys and Questionnaires MH - Italy MH - Time Factors OTO - NOTNLM OT - Actigraphy OT - Assessment OT - Day and night sleep OT - LENA OT - Naps OT - Sensitivity levels OT - Subjective and objective tools COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/10/12 18:27 MHDA- 2025/11/17 00:29 CRDT- 2025/10/12 17:59 PHST- 2025/07/08 00:00 [received] PHST- 2025/09/22 00:00 [revised] PHST- 2025/09/27 00:00 [accepted] PHST- 2025/11/17 00:29 [medline] PHST- 2025/10/12 18:27 [pubmed] PHST- 2025/10/12 17:59 [entrez] AID - S1389-9457(25)00513-1 [pii] AID - 10.1016/j.sleep.2025.106838 [doi] PST - ppublish SO - Sleep Med. 2025 Dec;136:106838. doi: 10.1016/j.sleep.2025.106838. Epub 2025 Sep 29. PMID- 41076450 OWN - NLM STAT- MEDLINE DCOM- 20251011 LR - 20261010 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 184 IP - 11 DP - 2025 Oct 11 TI - Evaluation of ChatGPT-4 responses on physical activity guidance in children with cystic fibrosis: reliability, quality, and readability. PG - 676 LID - 10.1007/s00431-025-06488-9 [doi] AB - ChatGPT-4 is a widely used large language model that provides instant answers to a variety of health-related questions in different medical fields. This study aims to evaluate the reliability, quality, accuracy, and readability of ChatGPT's responses to frequently asked questions regarding physical activity in children with cystic fibrosis (CF).The responses of ChatGPT-4 to 60 frequently asked questions related to physical activity and its effects on the condition of children with CF were categorized into five thematic (S1-S5) groups. These responses were then evaluated for reliability, quality, accuracy, and readability using the modified DISCERN (mDISCERN) tool, the Global Quality Scale (GQS), a five-point Likert scale, and the Flesch Reading Ease Scale (FRE), respectively.The mean scores for mDISCERN, GQS, and accuracy ranged from 3.38 (S2) to 3.82 (S4), 3.91 (S2, S4) to 4.25 (S5), and 4.27 (S1, S4) to 4.78 (S3), with overall means of 3.5, 3.98, and 4.38, respectively. The readability mean scores varied from 29.99 (S5) to 46.31 (S3), with a total mean of 38.07. The ICC values for the mDISCERN, GQS, and accuracy were 0.746, 0.666, and 0.665, respectively. CONCLUSION: This study revealed that ChatGPT-4 provides moderate to high levels of reliability, quality and accuracy in responses about physical activity in children with CF. Low FRE scores showed most responses were "difficult" for the target age group. Although ChatGPT-4 serves as a useful supplementary tool for patients with CF, professional supervision and further validation are essential for safe and effective use in clinical contexts. WHAT IS KNOWN: * Physical activity benefits children with cystic fibrosis (CF), yet access to reliable, understandable educational materials is limited. AI tools like ChatGPT-4 are increasingly used in health communication, but their reliability, accuracy, and readability remain uncertain. WHAT IS NEW: * This study systematically evaluates ChatGPT-4 responses to CF-related physical activity questions, showing moderate-to-high reliability, quality, and accuracy, but low readability, highlighting the need for adaptation for pediatric use. CI - (c) 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Celik, Zeliha AU - Celik Z AUID- ORCID: 0000-0003-2550-7791 AD - Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Amasya University, Amasya, Turkiye. zelihacelik1@hotmail.com. FAU - Sari, Fulden AU - Sari F AUID- ORCID: 0000-0002-5628-698X AD - Department of Physiotherapy and Rehabilitation, Faculty of Physical Therapy and Rehabilitation, Bingol University, Bingol, Turkiye. LA - eng PT - Journal Article DEP - 20251011 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Cystic Fibrosis/therapy MH - Child MH - Reproducibility of Results MH - *Exercise MH - *Comprehension MH - Female MH - Male MH - Surveys and Questionnaires/standards MH - Adolescent MH - *Health Literacy MH - Generative Artificial Intelligence OTO - NOTNLM OT - Artificial intelligence OT - ChatGPT4 OT - Counseling OT - Cystic fibrosis OT - Physical activity COIS- Declarations. Ethics approval: Since the study did not include human participants and solely compared computer-generated data with expert-produced information, ethical committee approval was not required. Competing interests: The authors declare no competing interests. EDAT- 2025/10/12 00:33 MHDA- 2025/10/12 00:34 CRDT- 2025/10/11 23:13 PHST- 2025/07/28 00:00 [received] PHST- 2025/09/16 00:00 [accepted] PHST- 2025/09/08 00:00 [revised] PHST- 2025/10/12 00:34 [medline] PHST- 2025/10/12 00:33 [pubmed] PHST- 2025/10/11 23:13 [entrez] AID - 10.1007/s00431-025-06488-9 [pii] AID - 10.1007/s00431-025-06488-9 [doi] PST - epublish SO - Eur J Pediatr. 2025 Oct 11;184(11):676. doi: 10.1007/s00431-025-06488-9. PMID- 41075677 OWN - NLM STAT- MEDLINE DCOM- 20251113 LR - 20260507 IS - 1878-5883 (Electronic) IS - 0022-510X (Linking) VI - 478 DP - 2025 Nov 15 TI - Trends in prevalence and incidence of multiple sclerosis in the Israeli Jewish and Arab populations. PG - 123721 LID - S0022-510X(25)00341-7 [pii] LID - 10.1016/j.jns.2025.123721 [doi] AB - BACKGROUND AND OBJECTIVES: There is a worldwide trend of increasing prevalence and incidence of multiple sclerosis (MS). A previous epidemiological survey conducted a quarter-century ago showed a substantially lower prevalence of MS among Israeli Arabs compared to Israeli Jews. We aimed to explore trends in MS prevalence and incidence among Israel's diverse populations over the past decade. METHODS: This population-based study utilizes the Clalit Health Services (CHS) database. CHS is Israel's largest healthcare organization, providing mandatory and universally funded healthcare to about half of the Israeli population. We used a previously validated algorithm to identify people with MS in the CHS database and analyzed trends in prevalence and incidence, stratified by sex and ethnicity. RESULTS: The prevalence of MS in Israel per 100,000 people increased from 65 in 2010 to 95 in 2021. The annual incidence rate per 100,000 people rose from 3.6 in 2010 to 5.2 in 2021. Throughout the past decade, MS prevalence remained higher among Israeli Jews than Israeli Arabs. However, during the study period, MS incidence among Israeli Arab females increased steeply, reaching a rate comparable to that of Israeli Jewish females. CONCLUSIONS: The prevalence and incidence of multiple sclerosis in Israel are increasing. A sharp rise in MS incidence among Israeli Arab females was observed, possibly linked to lifestyle changes, such as urbanization, decreasing birth rates, and rising childhood obesity. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Spierer, Ronen AU - Spierer R AD - Multiple Sclerosis and Neuroimmunology Center, Department of Neurology, Lady Davis Carmel Medical Center, Haifa, Israel. FAU - Hurani, Maha AU - Hurani M AD - Multiple Sclerosis and Neuroimmunology Center, Department of Neurology, Lady Davis Carmel Medical Center, Haifa, Israel. FAU - Stein, Nili AU - Stein N AD - Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel. FAU - Rawashdeh, Amir AU - Rawashdeh A AD - Multiple Sclerosis and Neuroimmunology Center, Department of Neurology, Lady Davis Carmel Medical Center, Haifa, Israel. FAU - Bloch, Sivan AU - Bloch S AD - Multiple Sclerosis and Neuroimmunology Center, Department of Neurology, Lady Davis Carmel Medical Center, Haifa, Israel; Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. FAU - Golan, Daniel AU - Golan D AD - Multiple Sclerosis and Neuroimmunology Center, Department of Neurology, Lady Davis Carmel Medical Center, Haifa, Israel; Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. Electronic address: danielgo1@clalit.org.il. LA - eng PT - Journal Article DEP - 20251009 PL - Netherlands TA - J Neurol Sci JT - Journal of the neurological sciences JID - 0375403 SB - IM MH - Humans MH - *Multiple Sclerosis/epidemiology/ethnology MH - Israel/epidemiology MH - Female MH - *Arabs/statistics & numerical data MH - Prevalence MH - *Jews/statistics & numerical data MH - Male MH - Incidence MH - Adult MH - Middle Aged MH - Young Adult MH - Aged MH - Adolescent OTO - NOTNLM OT - Epidemiology OT - Incidence, prevalence OT - Multiple sclerosis COIS- Declaration of competing interest The authors declare that they have no conflict of interest. EDAT- 2025/10/12 00:33 MHDA- 2025/11/13 06:30 CRDT- 2025/10/11 18:09 PHST- 2025/04/13 00:00 [received] PHST- 2025/09/26 00:00 [revised] PHST- 2025/10/06 00:00 [accepted] PHST- 2025/11/13 06:30 [medline] PHST- 2025/10/12 00:33 [pubmed] PHST- 2025/10/11 18:09 [entrez] AID - S0022-510X(25)00341-7 [pii] AID - 10.1016/j.jns.2025.123721 [doi] PST - ppublish SO - J Neurol Sci. 2025 Nov 15;478:123721. doi: 10.1016/j.jns.2025.123721. Epub 2025 Oct 9. PMID- 41074469 OWN - NLM STAT- MEDLINE DCOM- 20260515 LR - 20260515 IS - 1365-2648 (Electronic) IS - 0309-2402 (Linking) VI - 82 IP - 6 DP - 2026 Jun TI - Effectiveness of the Preschool Children eHealth Cardiac Rehabilitation Program After Congenital Heart Surgery: A Randomised Controlled Trial. PG - 6857-6871 LID - 10.1111/jan.70217 [doi] AB - AIM(S): To develop the Preschool Children eHealth Cardiac Rehabilitation programme based on the Interaction Model of Client Health Behaviour, and to evaluate its effects on children after congenital heart surgery. DESIGN: A parallel two-arm randomised controlled trial was conducted. METHODS: A total of 84 participants were recruited from July 2022 to June 2023 and randomly assigned to either the intervention group (n = 40) or control group (n = 44). The intervention group participated in a 3-month eHealth Cardiac Rehabilitation programme, while the control group received routine care. Outcomes were measured at baseline, 3 months post baseline (intervention endpoint), and 6 months post baseline. Eighty participants completed the study. RESULTS: Compared to the intervention group, the control group demonstrated significantly worse outcomes at both 3 and 6 months, including a higher risk of heart failure, lower left ventricular ejection fraction scores, and shorter 6-min walk distance tests. The intervention group engaged in significantly more vigorous physical activity. Significant between group differences were also observed in parental knowledge, attitudes, behaviours and trust levels. Additionally, the proportion of parents experiencing anxiety decreased significantly more in the intervention group by 6 months post baseline. CONCLUSION: This pioneering eHealth programme transforms home-based rehabilitation for preschool children with congenital heart disease, addressing a critical gap in accessible and long-term paediatric cardiac rehabilitation care. IMPLICATIONS FOR THE PROFESSION AND/OR PATIENT CARE: The use of eHealth programmes is valuable for improving paediatric cardiac rehabilitation by empowering parents, enhancing care continuity, and reducing barriers to accessing specialised services in paediatric care, especially in areas with limited medical resources. IMPACT: This study establishes the first validated eHealth framework for family-centred cardiac rehabilitation in preschool children following congenital heart surgery, addressing the critically low uptake of previously home-based rehabilitation. It also provides clinicians with a scalable solution for delivering care in underserved regions lacking access to specialised cardiac services. REPORTING METHOD: This study adhered to the CONSORT checklist guidelines for reporting randomised controlled trials. PATIENT OR PUBLIC CONTRIBUTION: This study did not include patient or public involvement in its design, conduct, or reporting. TRIAL AND PROTOCOL REGISTRATION: This study was a randomised controlled clinical trial. The research protocol was registered with the China Clinical Trial Registration Center (registration number: ChiCTR2200062022; https://www.chictr.org.cn/showproj.html?proj=174261). CI - (c) 2025 John Wiley & Sons Ltd. FAU - Luo, Wenyi AU - Luo W AUID- ORCID: 0000-0002-2982-8093 AD - Department of Nursing, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. AD - Department of Thoracic and Cardiovascular Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Chen, Lin AU - Chen L AUID- ORCID: 0009-0003-6995-8137 AD - Department of Thoracic and Cardiovascular Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Cai, Xiaoman AU - Cai X AD - Department of Thoracic and Cardiovascular Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Yang, Zhimin AU - Yang Z AD - Department of Nursing, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Deng, Hanfang AU - Deng H AD - Department of Nursing, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Xu, Yichao AU - Xu Y AD - Department of Rehabilitation, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Hickey, Patricia AU - Hickey P AD - Cardiovascular, Perioperative and Critical Care, Boston Children's Hospital, Boston, MA, USA. FAU - Zhang, Yaqing AU - Zhang Y AD - Editorial Department of Journal of Shanghai Jiao Tong University (Medical Science), Shanghai, China. LA - eng GR - SJTUHLXK2021/the 2021 Core Member of Nursing in Shanghai Jiao Tong University School of Medicine/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20251010 PL - England TA - J Adv Nurs JT - Journal of advanced nursing JID - 7609811 SB - IM MH - Humans MH - Child, Preschool MH - Female MH - *Heart Defects, Congenital/surgery/rehabilitation MH - Male MH - *Telemedicine MH - *Cardiac Rehabilitation/methods MH - *Cardiac Surgical Procedures/rehabilitation MH - Parents/psychology OTO - NOTNLM OT - cardiac rehabilitation OT - congenital heart disease OT - eHealth OT - nursing OT - preschool children OT - randomised controlled trial EDAT- 2025/10/11 06:31 MHDA- 2026/05/15 06:29 CRDT- 2025/10/11 01:43 PHST- 2025/08/04 00:00 [revised] PHST- 2024/05/10 00:00 [received] PHST- 2025/08/30 00:00 [accepted] PHST- 2026/05/15 06:29 [medline] PHST- 2025/10/11 06:31 [pubmed] PHST- 2025/10/11 01:43 [entrez] AID - 10.1111/jan.70217 [doi] PST - ppublish SO - J Adv Nurs. 2026 Jun;82(6):6857-6871. doi: 10.1111/jan.70217. Epub 2025 Oct 10. PMID- 41073505 OWN - NLM STAT- MEDLINE DCOM- 20251010 LR - 20251013 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Oct 10 TI - Exploring factors influencing sustainable behaviors in undergraduate students' sports participation through model development and validation. PG - 35460 LID - 10.1038/s41598-025-19284-0 [doi] LID - 35460 AB - Sustained participation in sports yields substantial benefits for students, both physically, psychologically, and socially. However, long-term engagement in sports activities remains a persistent challenge in higher education contexts. This study aimed to develop and validate a comprehensive model that identifies and explains the key factors influencing sustainable sports participation behaviors among Chinese undergraduate students. A sequential mixed-methods design was employed. In the qualitative phase, semi-structured interviews were conducted with 13 experts purposively selected for their knowledge in sports education and policy. Thematic analysis identified five core dimensions influencing sports participation: attitudinal, behavioral, environmental, cultural, and technical. Based on these findings, a structured 31-item Likert-scale questionnaire was developed and administered to 384 undergraduate students from the College of Physical Education and Health at East China Normal University. Quantitative data were analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM) to validate the model. The instrument demonstrated strong content validity (CVR = 0.99; CVI = 0.99) and internal consistency (Cronbach's alpha = 0.88). PLS-SEM results confirmed the model's structural integrity, with attitude and environmental support emerging as the most influential predictors of sustained participation. Additionally, technical skills and cultural perceptions played mediating roles in facilitating long-term sports engagement. This study presents a theoretically and empirically grounded model for understanding sustainable sports participation among undergraduate students in China. The findings underscore the importance of developing multidimensional, context-sensitive strategies to promote long-term participation in sports. For practice, the study suggests tailored institutional interventions that enhance environmental support and promote positive cultural attitudes toward physical activity. For research, it advocates cross-cultural replication and longitudinal investigations to generalize and extend the model's applicability. CI - (c) 2025. The Author(s). FAU - Yang, Xinrui AU - Yang X AD - College of Physical Education and Health, East China Normal University, Shanghai, China. FAU - Esmaeili, Ali AU - Esmaeili A AD - Allameh Tabataba'i University, Tehran, Iran. ali.esmaeili@atu.ac.ir. LA - eng PT - Journal Article DEP - 20251010 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Male MH - *Students/psychology MH - Young Adult MH - *Sports/psychology MH - Surveys and Questionnaires MH - China MH - Universities MH - Adult MH - Adolescent PMC - PMC12514135 OTO - NOTNLM OT - China OT - Mixed-methods OT - PLS-SEM OT - Sports participation OT - Student engagement OT - Sustainable behaviors COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: The studies involving human participants were reviewed and approved by the Institutional Review Board of East China Normal University. The patients/participants provided their written informed consent to participate in this study. The study was conducted in accordance with the Declaration of Helsinki. EDAT- 2025/10/11 00:32 MHDA- 2025/10/11 00:33 PMCR- 2025/10/10 CRDT- 2025/10/10 23:25 PHST- 2025/07/07 00:00 [received] PHST- 2025/09/08 00:00 [accepted] PHST- 2025/10/11 00:33 [medline] PHST- 2025/10/11 00:32 [pubmed] PHST- 2025/10/10 23:25 [entrez] PHST- 2025/10/10 00:00 [pmc-release] AID - 10.1038/s41598-025-19284-0 [pii] AID - 19284 [pii] AID - 10.1038/s41598-025-19284-0 [doi] PST - epublish SO - Sci Rep. 2025 Oct 10;15(1):35460. doi: 10.1038/s41598-025-19284-0. PMID- 41072871 OWN - NLM STAT- MEDLINE DCOM- 20251104 LR - 20251104 IS - 1573-2517 (Electronic) IS - 0165-0327 (Linking) VI - 393 IP - Pt A DP - 2026 Jan 15 TI - Influence of childhood excess weight on cognitive, behavioural and emotional outcomes. PG - 120410 LID - S0165-0327(25)01852-X [pii] LID - 10.1016/j.jad.2025.120410 [doi] AB - BACKGROUND: Obesity, considered a worldwide epidemic, generate great interest to the scientific community due to its impact on public health. Particularly in children because of their vulnerability. In view of the bidirectional relationship between obesity and neurodevelopmental aspects, this study aims to evaluate the effect of excess weight on cognitive and behavioural development. METHODS: A total of 130 Spanish children (3 to 12 years) were included. Cognitive function and behaviour were assessed using the validated Wechsler Intelligence Scale for Children-V (WISC-V) and Behaviour Assessment System for Children-3 (BASC-3) tests, respectively. Individuals were classified into groups according to body mass index (BMI) (normal weight and overweight/obesity). Multivariable logistic regression models were performed to address the influence of excess weight on cognitive-behavioural functioning. RESULTS: The results showed that infants who had overweight/obesity were more likely to have lower scores on the full-scale intelligence quotient (FSIQ: OR adjusted = 3.81, p = 0.006), verbal comprehension (VCI: OR adjusted = 2.57, p = 0.045), fluid reasoning (FRI: OR adjusted = 2.79, p value = 0.030) and working memory index (WMI: OR adjusted = 3.59, p = 0.008). No statistically significant results were found between excess weight and behavioural outcomes after adjustment for confounding factors. Secondly, Spearman's correlation analyses revealed a set of inverse correlations between cognitive ability and various behavioural and emotional problems, especially in cases group. CONCLUSIONS: In conclusion, excess weight may be negatively associated with a worse cognitive performance. Further, poorer cognitive function may lead to greater vulnerability to neurobehavioral disturbances in children with excess weight. These results underscore the need of further investigation. CI - Copyright (c) 2025 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Gonzalez-Palacios, Patricia AU - Gonzalez-Palacios P AD - Department of Nutrition and Food Science, University of Granada, Granada, Spain; "Jose Mataix Verdu" Institute of Nutrition and Food Technology (INYTA), Biomedical Research Centre (CIBM), University of Granada, Granada, Spain. Electronic address: pgonzapa@ugr.es. FAU - Ramirez, Viviana AU - Ramirez V AD - Department of Nutrition and Food Science, University of Granada, Granada, Spain; "Jose Mataix Verdu" Institute of Nutrition and Food Technology (INYTA), Biomedical Research Centre (CIBM), University of Granada, Granada, Spain; Instituto de Investigacion Biosanitaria ibs. GRANADA, Granada, Spain. Electronic address: vivianarl@ugr.es. FAU - Muros, Jose Joaquin AU - Muros JJ AD - Department of Didactics of Body Expression, Faculty of Education Science, University of Granada, 18071, Granada, Spain. Electronic address: jjmuros@ugr.es. FAU - Gonzalez-Domenech, Pablo Jose AU - Gonzalez-Domenech PJ AD - Department of Psychiatry, University of Granada, Granada, Spain; Multicentre CTS-549 Research Group (Psychiatry and Neurosciences), Junta de Andalucia, Granada, Spain. Electronic address: pgdomenech@ugr.es. FAU - Baca, Miguel Angel AU - Baca MA AD - Center of Health and Psychology Mensana, Granada, Spain. Electronic address: mabaca@cop.es. FAU - Monteagudo, Celia AU - Monteagudo C AD - Department of Nutrition and Food Science, University of Granada, Granada, Spain; "Jose Mataix Verdu" Institute of Nutrition and Food Technology (INYTA), Biomedical Research Centre (CIBM), University of Granada, Granada, Spain; Instituto de Investigacion Biosanitaria ibs. GRANADA, Granada, Spain. Electronic address: celiams@ugr.es. FAU - Rivas, Ana AU - Rivas A AD - Department of Nutrition and Food Science, University of Granada, Granada, Spain; "Jose Mataix Verdu" Institute of Nutrition and Food Technology (INYTA), Biomedical Research Centre (CIBM), University of Granada, Granada, Spain; Instituto de Investigacion Biosanitaria ibs. GRANADA, Granada, Spain. Electronic address: amrivas@ugr.es. LA - eng PT - Journal Article DEP - 20251008 PL - Netherlands TA - J Affect Disord JT - Journal of affective disorders JID - 7906073 SB - IM MH - Humans MH - Male MH - Female MH - Child MH - Child, Preschool MH - Body Mass Index MH - *Cognition/physiology MH - *Pediatric Obesity/psychology MH - *Overweight/psychology MH - Spain MH - *Emotions MH - Intelligence MH - *Child Behavior/psychology MH - Wechsler Scales OTO - NOTNLM OT - BMI OT - Behaviour OT - Cognition OT - Neurodevelopment OT - Obesity OT - Overweight COIS- Declaration of competing interest The authors declare no conflict of interest. EDAT- 2025/10/11 00:31 MHDA- 2025/11/04 06:29 CRDT- 2025/10/10 19:37 PHST- 2025/07/22 00:00 [received] PHST- 2025/09/23 00:00 [revised] PHST- 2025/10/06 00:00 [accepted] PHST- 2025/11/04 06:29 [medline] PHST- 2025/10/11 00:31 [pubmed] PHST- 2025/10/10 19:37 [entrez] AID - S0165-0327(25)01852-X [pii] AID - 10.1016/j.jad.2025.120410 [doi] PST - ppublish SO - J Affect Disord. 2026 Jan 15;393(Pt A):120410. doi: 10.1016/j.jad.2025.120410. Epub 2025 Oct 8. PMID- 41070930 OWN - NLM STAT- MEDLINE DCOM- 20260208 LR - 20260208 IS - 1550-9613 (Electronic) IS - 0278-4297 (Linking) VI - 45 IP - 3 DP - 2026 Mar TI - Ultrasound Viscoelastic Imaging for Pediatric Henoch-Schonlein Purpura Nephritis: A Noninvasive Approach for Diagnosis and Inflammation Assessment. PG - 531-546 LID - 10.1002/jum.70086 [doi] AB - OBJECTIVES: This study aimed to evaluate the feasibility of ultrasound viscoelastic imaging for assessing Henoch-Schonlein purpura nephritis (HSPN) in children and to explore the correlation between viscosity parameters and inflammatory activity. METHODS: In this retrospective study, we initially collected data from 190 children diagnosed with Henoch-Schonlein purpura (HSP). After applying inclusion and exclusion criteria, 169 patients were finally enrolled, comprising 80 cases of HSP and 89 cases of HSPN confirmed by renal biopsy. All participants underwent ultrasound viscoelastic examination, and their clinical characteristics and laboratory data were recorded. RESULTS: The results demonstrated that ultrasound viscoelastic imaging exhibited excellent diagnostic performance for HSPN, with the area under the curve (AUC) values of 0.91, 0.84, and 0.83 for renal cortical elasticity (Emean), viscosity coefficient (Vmean), and dispersion coefficient (Dmean), respectively. The diagnostic efficacy was further improved when these parameters were combined (AUC = 0.95). Multivariate logistic regression analysis identified Emean, Vmean, urinary white blood cell count, and serum albumin as independent predictors of HSPN. Notably, the HSPN group showed significantly higher age and body mass index (BMI) compared to the HSP group. Importantly, viscosity parameters (Vmean) demonstrated significant correlations with white blood cell count (WBC; r = 0.238, p = .002) and albumin levels (r = -0.274, p < .001), suggesting its favorable sensitivity in reflecting inflammatory activity. However, its ability to differentiate between pathological subtypes of HSPN remains limited. CONCLUSION: Ultrasound viscoelastic imaging represents a novel, noninvasive modality with potential value in identifying HSPN. Vmean showed greater sensitivity in assessing inflammatory activity. CI - (c) 2025 American Institute of Ultrasound in Medicine. FAU - Liu, Yameng AU - Liu Y AUID- ORCID: 0009-0007-0792-0909 AD - Department of Ultrasound Medical, The Henan University of Chinese Medicine, Zhengzhou, China. FAU - Chen, Jie AU - Chen J AD - Department of Ultrasound Medical, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China. FAU - Pian, Linping AU - Pian L AD - Department of Ultrasound Medical, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China. FAU - Li, Chao AU - Li C AD - Department of Ultrasound Medical, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China. FAU - Han, Feiyan AU - Han F AD - Department of Ultrasound Medical, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China. FAU - Liu, Min AU - Liu M AD - Department of Ultrasound Medical, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China. FAU - Zhao, Jingjing AU - Zhao J AD - Department of Ultrasound Medical, The Henan University of Chinese Medicine, Zhengzhou, China. FAU - Liu, Jiawei AU - Liu J AD - Department of Ultrasound Medical, The Henan University of Chinese Medicine, Zhengzhou, China. FAU - Zeng, Cheng AU - Zeng C AD - Department of Ultrasound Medical, The Henan University of Chinese Medicine, Zhengzhou, China. LA - eng GR - 2025ZY2006/Henan Provincial Traditional Chinese Medicine Scientific Research Project/ PT - Journal Article DEP - 20251010 PL - England TA - J Ultrasound Med JT - Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine JID - 8211547 SB - IM MH - Humans MH - *IgA Vasculitis/complications/diagnostic imaging MH - Male MH - Female MH - Child MH - Retrospective Studies MH - *Nephritis/diagnostic imaging/etiology MH - Child, Preschool MH - *Elasticity Imaging Techniques/methods MH - Adolescent MH - Ultrasonography/methods MH - Inflammation/diagnostic imaging MH - Kidney/diagnostic imaging MH - Sensitivity and Specificity MH - Reproducibility of Results MH - Feasibility Studies OTO - NOTNLM OT - Henoch-Schonlein nephritis OT - IgA vasculitis OT - inflammation OT - ultrasound OT - viscoelasticity EDAT- 2025/10/10 17:31 MHDA- 2026/02/09 00:29 CRDT- 2025/10/10 08:43 PHST- 2025/09/11 00:00 [revised] PHST- 2025/07/25 00:00 [received] PHST- 2025/09/26 00:00 [accepted] PHST- 2026/02/09 00:29 [medline] PHST- 2025/10/10 17:31 [pubmed] PHST- 2025/10/10 08:43 [entrez] AID - 10.1002/jum.70086 [doi] PST - ppublish SO - J Ultrasound Med. 2026 Mar;45(3):531-546. doi: 10.1002/jum.70086. Epub 2025 Oct 10. PMID- 41070464 OWN - NLM STAT- MEDLINE DCOM- 20251010 LR - 20251016 IS - 2651-3463 (Electronic) IS - 1300-2163 (Print) IS - 1300-2163 (Linking) VI - 36 DP - 2025 TI - Conceptualization of Grazing: The Psychometric Properties of The Repetitive Eating Questionnaire (Rep[eat]-Q) Turkish Form. PG - 5 LID - 10.5080/u27276 [doi] AB - OBJECTIVE: Grazing, defined as the unplanned and repetitive consumption of small or moderate amounts of food without feeling hungry, has been particulary investigated in relation to insufficient weight loss or early weight regain following bariatric surgery in recent years. The aim of this study was to investigate the psychometric properties of the Turkish form of the Repetitive Eating Scale (Rep[eat]-Q), which assesses grazing within a standardized framework. METHOD: The sample of the study consisted of a total of 491 adults, including 334 females and 157 males, with ages ranging from 17 to 62 participated in the study. The data were collected using the Rep[eat]-Q Turkish Form, Three-Factor Eating Questionnaire (TFEQ-R21), CES-D Depression Scale (CES-D), and Generalized Anxiety Disorder Scale-7 (GAD-7). RESULTS: Results of the confirmatory factor analysis revealed that the structure of the Rep[eat]-Q Turkish Form aligns with the original form, indicating that the scale consists of two factors named Compulsive Grazing (CG) and Repetitive Eating (RE). The internal consistency coefficients were found to be 0.93 for the total scale score, 0.91 for the RE subscale, and 0.88 for the CG subscale. The test-retest reliability ranged from 0.73 to 0.83 (p<0.001). It was found that the total score of the Rep(eat)-Q is strongly positively correlated with Emotional Eating and Uncontrolled Eating subscales of the TFEQ-R21, and moderately positively correlated with the CES-D (depression) and the GAD-7 (anxiety). CONCLUSION: The findings of the study demonstrated that the Turkish version of the Rep(eat)-Q is a reliable and valid measure to assess grazing. FAU - Sendag, Meltem Anafarta AU - Sendag MA FAU - Tigrak, Arcan AU - Tigrak A FAU - Simsek, Derya Ozbek AU - Simsek DO LA - eng LA - tur PT - Journal Article PT - Validation Study TT - Coplenme Tarzi Yeme Tutumunun Kavramsallastirilmasi: Tekrarli Yeme Olcegi (Rep[eat]-Q) Turkce Formu Psikometrik Ozellikleri. DEP - 20240919 PL - Turkey TA - Turk Psikiyatri Derg JT - Turk psikiyatri dergisi = Turkish journal of psychiatry JID - 9425936 SB - IM MH - Humans MH - Psychometrics MH - Female MH - Adult MH - Male MH - Turkey MH - Reproducibility of Results MH - Adolescent MH - Surveys and Questionnaires MH - Middle Aged MH - Young Adult MH - *Feeding and Eating Disorders/psychology/diagnosis MH - *Feeding Behavior/psychology MH - Psychiatric Status Rating Scales PMC - PMC11987549 OTO - NOTNLM OT - Grazing OT - compulsive grazing repetitive eating. EDAT- 2025/10/10 06:29 MHDA- 2025/10/10 06:30 PMCR- 2023/10/12 CRDT- 2025/10/10 05:23 PHST- 2025/10/10 06:30 [medline] PHST- 2025/10/10 06:29 [pubmed] PHST- 2025/10/10 05:23 [entrez] PHST- 2023/10/12 00:00 [pmc-release] AID - 1379 [pii] AID - turkpsychiatry-36-36 [pii] AID - 10.5080/u27276 [doi] PST - ppublish SO - Turk Psikiyatri Derg. 2025;36:5. doi: 10.5080/u27276. Epub 2024 Sep 19. PMID- 41070082 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251010 LR - 20251219 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 12 DP - 2025 TI - Establishment and validation of a clinical prediction model for predicting early postpartum pelvic floor muscle weakness among primiparous women after vaginal delivery: a retrospective study. PG - 1605662 LID - 10.3389/fmed.2025.1605662 [doi] LID - 1605662 AB - BACKGROUND: Pelvic floor muscle weakness (PFMW) is a significant postpartum complication linked to pelvic floor dysfunction. PFMW impairs quality of life and requires early intervention. This study aimed to develop and validate a clinical prediction model for early postpartum PFMW in primiparous women after vaginal delivery. METHODS: This retrospective cohort study was conducted at a tertiary maternity hospital in Shanghai, China. Primiparous women with vaginal deliveries (July 2021-December 2023) were enrolled. Participants were assessed for PFMW using pelvic floor surface electromyography (sEMG) via the Glazer protocol at 42-90 days postpartum. Maternal and obstetric predictors were analyzed via univariable and multivariable logistic regression to construct a nomogram. Model performance was evaluated using concordance statistics (C-statistics), calibration curves, and decision curve analysis in both the training (n = 2,465) and validation (n = 1,049) cohorts. Internal validation was performed via ten-fold cross-validation. RESULTS: Among 3,514 enrolled women, PFMW occurred in 25.55% (898/3,514), with comparable baseline characteristics between cohorts (age, pre-pregnancy BMI; P > 0.05). Multivariable analysis revealed five independent predictors: maternal age (OR 1.156, 95% CI 1.116-1.999), gestational weight gain (OR 1.146, 95% CI 1.116-1.178), instrumental delivery (forceps: OR 1.904, 95% CI 1.336-2.714), prolonged second stage of labor (OR 1.026, 95% CI 1.022-1.029), and infant weight (OR 1.003, 95% CI 1.002-1.003). The nomogram demonstrated strong discrimination [C-statistic: 0.866 (95% CI 0.850-0.882) in the training cohort; 0.870 (0.819-0.903) in the validation cohort] and good calibration. Decision curve analysis confirmed the clinical utility across threshold probabilities (0-0.3). CONCLUSION: This study established a validated nomogram integrating maternal and obstetric factors to predict early postpartum PFMW in primiparous women after vaginal delivery. This tool may aid in the early identification of high-risk individuals, enabling targeted rehabilitation to mitigate long-term pelvic floor dysfunction. CI - Copyright (c) 2025 Dong, Chi, Liu, Liu, Chen, Wang and Liu. FAU - Dong, Huan AU - Dong H AD - The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. AD - Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Chi, Xiaolei AU - Chi X AD - The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. AD - Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Liu, Ye AU - Liu Y AD - The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. AD - Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Liu, Wenjuan AU - Liu W AD - The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. AD - Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Chen, Xinliang AU - Chen X AD - The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. AD - Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Wang, Xianjing AU - Wang X AD - The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. AD - Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Liu, Ping AU - Liu P AD - The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. AD - Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. LA - eng PT - Journal Article DEP - 20250924 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 EIN - Front Med (Lausanne). 2025 Dec 03;12:1750052. doi: 10.3389/fmed.2025.1750052. PMID: 41416087 PMC - PMC12504349 OTO - NOTNLM OT - clinical prediction model OT - early postpartum period OT - pelvic floor muscle weakness (PFMW) OT - primiparous women OT - vaginal delivery COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/10/10 06:28 MHDA- 2025/10/10 06:29 PMCR- 2025/09/24 CRDT- 2025/10/10 04:53 PHST- 2025/04/03 00:00 [received] PHST- 2025/09/04 00:00 [accepted] PHST- 2025/10/10 06:29 [medline] PHST- 2025/10/10 06:28 [pubmed] PHST- 2025/10/10 04:53 [entrez] PHST- 2025/09/24 00:00 [pmc-release] AID - 10.3389/fmed.2025.1605662 [doi] PST - epublish SO - Front Med (Lausanne). 2025 Sep 24;12:1605662. doi: 10.3389/fmed.2025.1605662. eCollection 2025. PMID- 41069820 OWN - NLM STAT- MEDLINE DCOM- 20251010 LR - 20251012 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Cluster analysis of motor coordination and health-related fitness in preschool children: population classification and variable contribution based on principal component analysis. PG - 1630387 LID - 10.3389/fpubh.2025.1630387 [doi] LID - 1630387 AB - BACKGROUND: The preschool period is critical for children's motor development and neural maturation. Fundamental motor skill development during this stage directly influences the nervous system's growth. Motor coordination ability serves as the foundation for children's physical fitness, health, and motor performance. OBJECTIVE: This study investigates the relationship between motor coordination and health-related fitness in preschool children, analyzing the extent of motor coordination's impact on physical fitness. Through principal component analysis (PCA) and cluster analysis, differences in motor coordination and fitness performance across child populations are identified, providing theoretical support for optimizing health promotion strategies. METHODS: Participants included 358 preschool children from a kindergarten in Weifang, Shandong, China., including demographic data such as parental education, socioeconomic background, and habitual physical activity participation collected via parent questionnaires to provide contextual information Motor coordination was assessed using the Movement Assessment Battery for Children-2 (MABC-2), while fitness tests (e.g., standing long jump, tennis throw, 10-meter shuttle run) were standardized into Z-scores. Statistical analyses included Pearson correlation, hierarchical regression, PCA, and cluster analysis. PCA component retention was based on eigenvalues >1 and scree plot inspection, while cluster validity was confirmed using the elbow method and silhouette coefficients. RESULTS: Motor coordination showed significant positive correlations with flexibility, strength, agility, and endurance. Hierarchical regression confirmed motor coordination's independent and significant influence on fitness outcomes, particularly in standing long jump and shuttle run. BMI exhibited a weak negative correlation with motor coordination. PCA revealed two principal components (Dim1: 31.7% variance, dominated by running and jumping; Dim2: 16.1% variance, emphasizing flexibility and tennis throw). Cluster analysis categorized children into three groups: "Comprehensive Excellence," "Agility Specialization," and "Basic Skill Needs." CONCLUSION: Motor coordination plays a pivotal role in preschool children's fitness development, particularly in agility and strength. PCA and cluster analysis highlighted distinct group differences, supported by validated retention and validation procedures, underscoring the need for targeted interventions to enhance motor coordination and overall health. CI - Copyright (c) 2025 Chen, Zhao, Zhang, Wang, He, Chen, Hu, Tang, Zhang, Xiao and Zhang. FAU - Chen, Xiaoxiao AU - Chen X AD - China Institute of Sport Science, Beijing, China. FAU - Zhao, Deqiang AU - Zhao D AD - China Institute of Sport Science, Beijing, China. FAU - Zhang, Aoyu AU - Zhang A AD - China Institute of Sport Science, Beijing, China. FAU - Wang, Chunmiao AU - Wang C AD - China Institute of Sport Science, Beijing, China. FAU - He, Jin AU - He J AD - China Institute of Sport Science, Beijing, China. FAU - Chen, Jiaxin AU - Chen J AD - China Institute of Sport Science, Beijing, China. FAU - Hu, Haixia AU - Hu H AD - Aiyumo Children and Youth Sports Health Research, Shandong, China. FAU - Tang, Xiaoni AU - Tang X AD - Changyi Experimental Kindergarten, Shandong, China. FAU - Zhang, Aiying AU - Zhang A AD - Changyi Experimental Kindergarten, Shandong, China. FAU - Xiao, Han AU - Xiao H AD - Weifang National Fitness Service Center, Shandong, China. FAU - Zhang, Yanfeng AU - Zhang Y AD - China Institute of Sport Science, Beijing, China. LA - eng PT - Journal Article DEP - 20250924 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Child, Preschool MH - Male MH - Female MH - *Physical Fitness/physiology MH - Cluster Analysis MH - Principal Component Analysis MH - *Motor Skills/physiology MH - China MH - Exercise/physiology MH - Surveys and Questionnaires PMC - PMC12504319 OTO - NOTNLM OT - correlation analysis OT - fitness index OT - health-related fitness OT - hierarchical regression OT - motor coordination OT - preschool children COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/10/10 06:28 MHDA- 2025/10/10 06:29 PMCR- 2025/09/24 CRDT- 2025/10/10 04:50 PHST- 2025/05/17 00:00 [received] PHST- 2025/09/08 00:00 [accepted] PHST- 2025/10/10 06:29 [medline] PHST- 2025/10/10 06:28 [pubmed] PHST- 2025/10/10 04:50 [entrez] PHST- 2025/09/24 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1630387 [doi] PST - epublish SO - Front Public Health. 2025 Sep 24;13:1630387. doi: 10.3389/fpubh.2025.1630387. eCollection 2025. PMID- 41068350 OWN - NLM STAT- MEDLINE DCOM- 20260128 LR - 20261009 IS - 1708-0428 (Electronic) IS - 0960-8923 (Linking) VI - 36 IP - 1 DP - 2026 Jan TI - Does the MBSAQIP Bariatric Surgical Risk/Benefit Calculator Accurately Predict Weight Loss in Adolescents? PG - 54-60 LID - 10.1007/s11695-025-08295-5 [doi] AB - BACKGROUND: The Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) online calculator incorporates individual patient data to predict weight loss up to 1 year after MBS, but it was derived from an adult database and has not been validated in younger cohorts. This study evaluates the accuracy of this calculator for adolescent MBS patients and explores patient factors which may be associated with prediction inaccuracy. METHODS: We include patients age 0.05). CONCLUSIONS: The MBASQIP calculator predictions show weak to moderate correlation with actual weight loss at 1 year and should be used with caution when counseling pediatric patients considering MBS. This project underscores the importance of building multi-institutional collaborations and databases specific to the pediatric MBS context. CI - (c) 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Kochis, Michael A AU - Kochis MA AD - Massachusetts General Hospital, Boston, United States. mkochis@mgh.harvard.edu. FAU - Chinn, Justine O AU - Chinn JO AD - Stanford Medicine, Stanford, United States. FAU - Nzenwa, Ikemsinachi C AU - Nzenwa IC AD - Massachusetts General Hospital, Boston, United States. FAU - Brennan, Kelly A AU - Brennan KA AD - Stanford Medicine, Stanford, United States. FAU - Pratt, Janey S A AU - Pratt JSA AD - Stanford Medicine, Stanford, United States. FAU - Griggs, Cornelia L AU - Griggs CL AD - Massachusetts General Hospital, Boston, United States. LA - eng PT - Journal Article DEP - 20251010 PL - United States TA - Obes Surg JT - Obesity surgery JID - 9106714 SB - IM MH - Humans MH - Adolescent MH - *Weight Loss MH - Male MH - Female MH - *Bariatric Surgery MH - Young Adult MH - *Pediatric Obesity/surgery MH - Risk Assessment MH - *Obesity, Morbid/surgery MH - Quality Improvement MH - Body Mass Index MH - Retrospective Studies OTO - NOTNLM OT - Adolescents OT - MBSAQIP OT - Metabolic and bariatric surgery OT - Pediatric obesity OT - Risk calculator OT - Weight loss COIS- Declarations. Ethical Approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required. Conflict of interest: The authors declare no competing interests. EDAT- 2025/10/10 00:29 MHDA- 2026/01/28 19:20 CRDT- 2025/10/09 23:39 PHST- 2025/02/13 00:00 [received] PHST- 2025/09/20 00:00 [accepted] PHST- 2025/02/25 00:00 [revised] PHST- 2026/01/28 19:20 [medline] PHST- 2025/10/10 00:29 [pubmed] PHST- 2025/10/09 23:39 [entrez] AID - 10.1007/s11695-025-08295-5 [pii] AID - 10.1007/s11695-025-08295-5 [doi] PST - ppublish SO - Obes Surg. 2026 Jan;36(1):54-60. doi: 10.1007/s11695-025-08295-5. Epub 2025 Oct 10. PMID- 41066862 OWN - NLM STAT- MEDLINE DCOM- 20251107 LR - 20251107 IS - 1873-6297 (Electronic) IS - 0001-6918 (Linking) VI - 260 DP - 2025 Oct TI - Scroll immersion and short-form video use: Predictors of attention, memory, and fatigue among Saudi social media users. PG - 105674 LID - S0001-6918(25)00987-4 [pii] LID - 10.1016/j.actpsy.2025.105674 [doi] AB - The widespread adoption of short-form video platforms has raised concerns about their potential impact on users' cognitive functioning. This study investigated the associations between short-form video use, scroll immersion, and perceived cognitive outcomes, specifically attention difficulty, working memory disruption, and cognitive fatigue, among social media users in Saudi Arabia. Adopting a cross-sectional correlational design, data were collected from 745 participants using a non-probability quota-based sampling strategy and a validated self-report instrument. Structural equation modelling revealed that usage frequency/duration and scroll immersion significantly predicted adverse cognitive outcomes. Scroll immersion, defined as habitual and unintentional engagement, consistently predicted all three outcomes. Moderation analysis showed that average daily screen time and gender influenced the relationship between usage and fatigue, while age did not. These results suggest that behavioural patterns of media engagement may be more influential than demographic characteristics in shaping cognitive strain. The findings support the need for targeted interventions promoting intentional media use and self-regulation strategies. Future research should employ objective cognitive assessments and longitudinal designs to better understand the direction and persistence. CI - Copyright (c) 2025 The Author. Published by Elsevier B.V. All rights reserved. FAU - Alruwaili, Reshaa F AU - Alruwaili RF AD - Department of Psychology, College of Social Sciences, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia. Electronic address: ralruwaili@imamu.edu.sa. LA - eng PT - Journal Article DEP - 20251008 PL - Netherlands TA - Acta Psychol (Amst) JT - Acta psychologica JID - 0370366 SB - IM MH - Humans MH - Female MH - Male MH - Saudi Arabia MH - *Social Media/statistics & numerical data MH - Adult MH - *Attention/physiology MH - Cross-Sectional Studies MH - Young Adult MH - *Memory, Short-Term/physiology MH - Adolescent MH - Middle Aged MH - *Fatigue MH - *Screen Time OTO - NOTNLM OT - Attention difficulty OT - Cognitive fatigue OT - Saudi social media users OT - Scroll immersion OT - Short-form video OT - Working memory disruption COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/10/09 18:28 MHDA- 2025/11/07 06:28 CRDT- 2025/10/09 18:01 PHST- 2025/06/29 00:00 [received] PHST- 2025/09/23 00:00 [revised] PHST- 2025/09/26 00:00 [accepted] PHST- 2025/11/07 06:28 [medline] PHST- 2025/10/09 18:28 [pubmed] PHST- 2025/10/09 18:01 [entrez] AID - S0001-6918(25)00987-4 [pii] AID - 10.1016/j.actpsy.2025.105674 [doi] PST - ppublish SO - Acta Psychol (Amst). 2025 Oct;260:105674. doi: 10.1016/j.actpsy.2025.105674. Epub 2025 Oct 8. PMID- 41065206 OWN - NLM STAT- MEDLINE DCOM- 20260307 LR - 20260726 IS - 1540-2010 (Electronic) IS - 1540-2002 (Linking) VI - 24 IP - 2 DP - 2026 Mar-Apr TI - A Case Series of Group Videoconference-Delivered Cognitive-Behavioral Therapy with Morning Light Therapy in Adolescents with Delayed Sleep Timing. PG - 160-176 LID - 10.1080/15402002.2025.2569376 [doi] AB - OBJECTIVES: This case series examined the feasibility and preliminary effects of group-based, videoconference-delivered cognitive-behavioral therapy (CBT) combined with morning light therapy (LT) in adolescents with delayed sleep timing. METHOD: Five females aged 14-16 years (M = 15.0, SD = 0.7) completed clinician-administered screening interviews, and baseline and post-treatment assessments, including circadian phase measurement, and validated measures of chronotype, bedtime procrastination, pre-sleep arousal, daytime sleepiness, anxiety, depression, and quality of life. Actigraphy was used for the duration of the study. The intervention included six weekly CBT sessions and short-wavelength wearable LT assigned for 1 hr daily following an advancing wake time schedule. RESULTS: One participant showed a 94-min circadian phase advance; others showed minimal phase advance, no change, or phase delays (n = 2). All participants reported earlier chronotype by post-treatment. Three advanced either sleep onset or wake time, with one showing both. Two showed increased total sleep time, primarily due to delayed wake time. Other objective sleep outcomes are presented. Bedtime procrastination, pre-sleep arousal, daytime sleepiness, depression, and quality of life improved, with modest reductions in anxiety. Challenges included napping, ADHD and anxiety comorbidity, scheduling barriers (homework, extracurricular activities, screen use), and resistance to earlier bedtimes. CONCLUSIONS: Results suggest heterogeneous circadian and sleep responses but consistent behavioral improvements. Extended LT duration, motivational enhancement, executive function or time management strategies, and behavioral economics-informed interventions may improve engagement and treatment efficacy. FAU - Ricketts, Emily J AU - Ricketts EJ AD - Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA. FAU - Rissman, Ariel J AU - Rissman AJ AD - Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA. FAU - Swisher, Valerie S AU - Swisher VS AD - Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA. FAU - Joyce, Daniel S AU - Joyce DS AD - School of Psychology & Wellbeing, University of Southern Queensland-Ipswich, Ipswich, QLD, Australia. FAU - Colwell, Christopher S AU - Colwell CS AD - Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA. FAU - Burgess, Helen J AU - Burgess HJ AD - Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA. LA - eng GR - K23 MH113884/MH/NIMH NIH HHS/United States PT - Journal Article DEP - 20251009 PL - England TA - Behav Sleep Med JT - Behavioral sleep medicine JID - 101149327 SB - IM MH - Humans MH - Female MH - *Cognitive Behavioral Therapy/methods MH - Adolescent MH - *Videoconferencing MH - *Phototherapy/methods MH - Circadian Rhythm/physiology MH - Quality of Life MH - Sleep/physiology MH - Treatment Outcome MH - *Psychotherapy, Group/methods MH - Anxiety/therapy MH - *Sleep Disorders, Circadian Rhythm/therapy MH - Depression/therapy EDAT- 2025/10/09 12:30 MHDA- 2026/03/08 01:38 CRDT- 2025/10/09 07:53 PHST- 2026/03/08 01:38 [medline] PHST- 2025/10/09 12:30 [pubmed] PHST- 2025/10/09 07:53 [entrez] AID - 10.1080/15402002.2025.2569376 [doi] PST - ppublish SO - Behav Sleep Med. 2026 Mar-Apr;24(2):160-176. doi: 10.1080/15402002.2025.2569376. Epub 2025 Oct 9. PMID- 41064569 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251009 LR - 20251011 IS - 2477-4073 (Electronic) IS - 2528-181X (Print) IS - 2477-4073 (Linking) VI - 11 IP - 5 DP - 2025 TI - Exploring practical issues in children's anthropometric measurements: A qualitative descriptive study involving Indonesian health professionals and community health workers. PG - 538-546 LID - 10.33546/bnj.3987 [doi] AB - BACKGROUND: Anthropometric measurements during early childhood are critical as they represent the initial stages at which nutritional status is determined. Practitioners who measure children's growth must have similar and adequate skills in anthropometric measurement to ensure the validity of data regarding children's nutritional status, particularly concerning stunting prevalence. OBJECTIVE: This study aimed to explore the measurement practices conducted by community health workers (CHWs) in Indonesia, who are responsible for providing data related to children's growth and, consequently, their nutritional status. METHODS: A qualitative descriptive design was employed using online focus group discussions ranging from 1 to 1.5 hours. Data were collected from ten health professionals and eight CHWs, with analysis performed using thematic analysis. RESULTS: Four themes emerged: barriers to measurement accuracy, varied skills in measurement, mothers' behavior influenced by children's reactions, and strategies for dealing with traumatized children. CONCLUSION: Practical issues that arose during routine anthropometric measurements included the reliability of measurements, the skill levels of examiners, the interplay between mothers' and children's reactions, and approaches to managing traumatized children during measurements. To effectively enhance integrated health posts (Posyandu) services, it is crucial to maintain calibrated, validated equipment and implement comprehensive training with periodic refreshers for CHWs. Additionally, improving facility infrastructure, fostering CHWs' communication skills, and simplifying child-friendly measurement procedures will collectively optimize service quality, promote cooperation, and strengthen community trust. CI - (c) The Author(s) 2025. FAU - Wanda, Dessie AU - Wanda D AUID- ORCID: 0000-0003-0659-1748 AD - Department of Pediatric Nursing, Faculty of Nursing, Universitas Indonesia, Depok, Jawa Barat, Indonesia. FAU - Astuti, Astuti AU - Astuti A AUID- ORCID: 0000-0001-5676-2408 AD - Department of Pediatric Nursing, Faculty of Nursing, Universitas Indonesia, Depok, Jawa Barat, Indonesia. FAU - Adawiyah, Robiyatul AU - Adawiyah R AUID- ORCID: 0000-0002-1003-3346 AD - Department of Pediatric Nursing, Faculty of Nursing, Universitas Indonesia, Depok, Jawa Barat, Indonesia. AD - Universitas Indonesia Hospital, Depok, Jawa Barat, Indonesia. FAU - Syaiful, Afifah Ayu AU - Syaiful AA AUID- ORCID: 0000-0002-2273-5695 AD - Department of Pediatric Nursing, Faculty of Nursing, Universitas Indonesia, Depok, Jawa Barat, Indonesia. FAU - Azizah, Latifah Fajri Nur AU - Azizah LFN AUID- ORCID: 0009-0003-5422-2012 AD - Department of Pediatric Nursing, Faculty of Nursing, Universitas Indonesia, Depok, Jawa Barat, Indonesia. FAU - Azkiyati, Ade Maya AU - Azkiyati AM AUID- ORCID: 0009-0007-5278-3376 AD - Department of Pediatric Nursing, Faculty of Nursing, Universitas Indonesia, Depok, Jawa Barat, Indonesia. FAU - Huda, Mega Hasanul AU - Huda MH AUID- ORCID: 0000-0002-8381-7774 AD - Department of Pediatric Nursing, Faculty of Nursing, Universitas Indonesia, Depok, Jawa Barat, Indonesia. LA - eng PT - Journal Article DEP - 20251005 PL - Indonesia TA - Belitung Nurs J JT - Belitung nursing journal JID - 101685037 PMC - PMC12502755 OTO - NOTNLM OT - anthropometry OT - child OT - community health centers OT - community health workers OT - growth COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analysis, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2025/10/09 06:28 MHDA- 2025/10/09 06:29 PMCR- 2025/10/05 CRDT- 2025/10/09 05:05 PHST- 2025/04/22 00:00 [received] PHST- 2025/05/20 00:00 [revised] PHST- 2025/08/03 00:00 [accepted] PHST- 2025/10/09 06:29 [medline] PHST- 2025/10/09 06:28 [pubmed] PHST- 2025/10/09 05:05 [entrez] PHST- 2025/10/05 00:00 [pmc-release] AID - BNJ-11-5-538 [pii] AID - 10.33546/bnj.3987 [doi] PST - epublish SO - Belitung Nurs J. 2025 Oct 5;11(5):538-546. doi: 10.33546/bnj.3987. eCollection 2025. PMID- 41061628 OWN - NLM STAT- MEDLINE DCOM- 20251107 LR - 20251107 IS - 1476-5616 (Electronic) IS - 0033-3506 (Linking) VI - 248 DP - 2025 Nov TI - Historic trends and future projections of the prevalence of adult excess weight in Scotland, 2003 to 2040: A modelling study. PG - 105981 LID - S0033-3506(25)00427-5 [pii] LID - 10.1016/j.puhe.2025.105981 [doi] AB - OBJECTIVES: The prevalence of excess weight in Scotland is higher than other UK nations and amongst the highest when compared with European Union countries. We aimed to use historic data to project estimates of the prevalence of excess weight in Scotland using Bayesian age-period-cohort modelling. STUDY DESIGN: A Bayesian age-period-cohort modelling study. METHODS: Interviewer-validated height and weight measurements were obtained from the Scottish Health Survey (2003-2019) to calculate body mass index (BMI). Relevant socio-demographic attributes were sourced to contribute to modelling and results stratification. Study outcomes were defined as overweight (BMI >/=25 kg/m(2)) and obesity (BMI >/=30 kg/m(2)). We estimated historic trends in study outcomes by sex and age-group, and projected future trends to 2040, using Bayesian hierarchical age-period-cohort modelling. RESULTS: In 2040, we estimate 3.3 million adult cases of overweight, of which 1.6 million are cases of obesity. Projections were more pronounced for obesity, compared to overweight, with an additional 66,000 male cases and 175,000 female cases projected between 2019 and 2040. Between 2003 and 2019, the proportion of male and female cases of both overweight and obesity aged 65 years and above have increased, a trend projected to further intensify as we move towards 2040. CONCLUSIONS: Left unaddressed, we estimate a substantial increase in adult excess weight in Scotland by 2040, particularly for females, compounded by increases in obesity and in the proportion of older cases. These findings are a warning signal of future adverse population health impacts and healthcare service sustainability pressures. Projections are not inevitable and underscore the need to accelerate progress on implementing preventative measures to address the food environment, and on further development of weight management and support services, to improve Scotland's population health. CI - Copyright (c) 2025 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved. FAU - De Pauw, Robby AU - De Pauw R AD - Department of Epidemiology and Public Health, Sciensano, Brussels, Belgium; Department of Rehabilitation Sciences, Ghent University, Ghent, Belgium. FAU - Lakha, Fatim AU - Lakha F AD - Clinical and Protecting Health Directorate, Public Health Scotland, UK; Directorate of Public Health, NHS Tayside, UK. FAU - Fletcher, Eilidh AU - Fletcher E AD - Data and Digital Innovation Directorate, Public Health Scotland, UK. FAU - Stockton, Diane L AU - Stockton DL AD - Clinical and Protecting Health Directorate, Public Health Scotland, UK. FAU - Baird, Emma AU - Baird E AD - Clinical and Protecting Health Directorate, Public Health Scotland, UK; Public Health Department, NHS Forth Valley, UK. FAU - Connolly, Suzanne AU - Connolly S AD - Population Health and Wellbeing Directorate, Public Health Scotland, UK. FAU - Devleesschauwer, Brecht AU - Devleesschauwer B AD - Department of Epidemiology and Public Health, Sciensano, Brussels, Belgium; Department of Translational Physiology, Infectiology and Public Health, Ghent University, Merelbeke, Belgium. FAU - Wyper, Grant M A AU - Wyper GMA AD - Clinical and Protecting Health Directorate, Public Health Scotland, UK; School of Health and Wellbeing, University of Glasgow, UK. Electronic address: grant.wyper@phs.scot. LA - eng PT - Journal Article DEP - 20251007 PL - Netherlands TA - Public Health JT - Public health JID - 0376507 SB - IM MH - Humans MH - Scotland/epidemiology MH - Female MH - Male MH - Middle Aged MH - Prevalence MH - Adult MH - Aged MH - *Overweight/epidemiology MH - Forecasting MH - *Obesity/epidemiology MH - Body Mass Index MH - Bayes Theorem MH - Young Adult MH - Cohort Studies MH - Health Surveys MH - Adolescent OTO - NOTNLM OT - BMI OT - Epidemiology OT - Foresight OT - Obesity OT - Public health OT - Weight EDAT- 2025/10/09 00:30 MHDA- 2025/11/08 00:28 CRDT- 2025/10/08 18:12 PHST- 2025/03/10 00:00 [received] PHST- 2025/08/28 00:00 [revised] PHST- 2025/09/27 00:00 [accepted] PHST- 2025/11/08 00:28 [medline] PHST- 2025/10/09 00:30 [pubmed] PHST- 2025/10/08 18:12 [entrez] AID - S0033-3506(25)00427-5 [pii] AID - 10.1016/j.puhe.2025.105981 [doi] PST - ppublish SO - Public Health. 2025 Nov;248:105981. doi: 10.1016/j.puhe.2025.105981. Epub 2025 Oct 7. PMID- 41059717 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260917 IS - 1747-0080 (Electronic) IS - 1446-6368 (Print) IS - 1446-6368 (Linking) VI - 83 IP - 4 DP - 2026 Sep TI - Change in diet quality and differences in characteristics in Australian adults who completed the Healthy Eating Quiz: A cohort study. PG - 526-536 LID - 10.1111/1747-0080.70049 [doi] AB - AIM: Investigate changes in diet quality scores in adults who repeated a brief online dietary assessment tool, the Healthy Eating Quiz, and whether changes in diet quality varied by sociodemographic variables, dietary characteristics, or motivations for completing the tool. METHODS: This is a secondary analysis of longitudinal data collected July 2019-May 2022. Data from respondents aged 16-100 years who repeated the dietary assessment tool were analysed, including diet quality, measured using the validated Australian Recommended Food Score (range 0-73), sociodemographic and dietary characteristics (gender, age, socioeconomic status, vegetarian status, and meal sharing), and the main motivation for completing the tool. Paired t-tests assessed change in score between first and second tool completion (reported as mean (SD)). One-way ANOVA was used to test whether mean change in score differed by respondent sociodemographic, dietary, or motivation variables. RESULTS: Across 5189 respondents (73.6% female, 42.0 (17.4) years), mean score improved by 2.28 points during a mean 231 (11) days (p <0.001). Non-vegetarians reported a significantly greater improvement in score than vegetarians (2.39 (6.78) versus 1.56 (6.97) points, p = 0.003). Similarly, those who ate main meals alone improved more (2.70 (7.05) points) compared to those who ate with one (2.15 (6.67) points) or >/=two others (2.14 (6.72) points, p = 0.035). CONCLUSION: Using the Healthy Eating Quiz, a diet quality assessment tool, on repeated occasions may contribute to improvements in diet quality in adults. CI - (c) 2025 Dietitians Australia. FAU - Fenton, Sasha AU - Fenton S AUID- ORCID: 0000-0002-4611-5810 AD - School of Health Sciences, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia. AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. FAU - Whatnall, Megan AU - Whatnall M AD - School of Health Sciences, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia. AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. FAU - Edwards, Hannah AU - Edwards H AD - School of Health Sciences, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia. FAU - Rae, Amelia AU - Rae A AD - School of Health Sciences, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia. FAU - Jansson, Anna AU - Jansson A AUID- ORCID: 0000-0001-9039-2033 AD - School of Health Sciences, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia. AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. FAU - Clarke, Erin D AU - Clarke ED AUID- ORCID: 0000-0001-8250-5990 AD - School of Health Sciences, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia. AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. FAU - Collins, Clare E AU - Collins CE AUID- ORCID: 0000-0003-3298-756X AD - School of Health Sciences, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia. AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. LA - eng GR - nib Foundation/ GR - National Health and Medical Research Council/ PT - Journal Article DEP - 20251008 PL - Australia TA - Nutr Diet JT - Nutrition & dietetics : the journal of the Dietitians Association of Australia JID - 101143078 SB - IM MH - Humans MH - Female MH - Adult MH - Australia MH - *Diet, Healthy/statistics & numerical data MH - Male MH - Middle Aged MH - Adolescent MH - Aged MH - Young Adult MH - Aged, 80 and over MH - Longitudinal Studies MH - Feeding Behavior MH - *Diet MH - Motivation MH - *Diet Surveys MH - *Nutrition Assessment PMC - PMC13575711 OTO - NOTNLM OT - Australian Recommended Food Score OT - Healthy Eating Quiz OT - diet quality OT - eating behaviours COIS- C.E.C. is the founder of the Healthy Eating Quiz. The Healthy Eating Quiz was first developed and published in the online format in 2012 through Newcastle Innovation, the University of Newcastle. There is no financial gain from individuals completing the online quiz. All other authors declare no conflicts of interest. EDAT- 2025/10/08 17:32 MHDA- 2026/09/15 11:37 PMCR- 2026/09/15 CRDT- 2025/10/08 07:02 PHST- 2025/08/27 00:00 [revised] PHST- 2025/03/25 00:00 [received] PHST- 2025/09/12 00:00 [accepted] PHST- 2026/09/15 11:37 [medline] PHST- 2025/10/08 17:32 [pubmed] PHST- 2025/10/08 07:02 [entrez] PHST- 2026/09/15 00:00 [pmc-release] AID - NDI70049 [pii] AID - 10.1111/1747-0080.70049 [doi] PST - ppublish SO - Nutr Diet. 2026 Sep;83(4):526-536. doi: 10.1111/1747-0080.70049. Epub 2025 Oct 8. PMID- 41059599 OWN - NLM STAT- MEDLINE DCOM- 20251008 LR - 20260925 IS - 2692-7691 (Electronic) IS - 2692-7691 (Linking) VI - 188 IP - 2 DP - 2025 Oct TI - Exploring Early Childhood Diet, Stress, Trophic Position and Dietary Protein Quality Using Amino Acid Nitrogen Isotope Compositions of Fingernail Keratin. PG - e70128 LID - 10.1002/ajpa.70128 [doi] LID - e70128 AB - OBJECTIVES: Evaluate the effectiveness of compound-specific nitrogen isotope analysis of amino acids (CSIA-AA) in reconstructing early childhood diets and detecting episodes of stress. Examine (1) proline's potential for identifying breastfeeding and weaning; (2) the influence of physiological and pathological stress on AA delta(15)N; (3) the reliability of trophic position (TP) estimates from phenylalanine (Phe) and glutamate (Glx) delta(15)N during dietary transitions; and (4) mother-infant trophic enrichment factors (TEF(Glx-Phe)) as indicators of infant dietary protein quality. MATERIALS AND METHODS: Three mother-infant dyads provided fingernail clippings (n = 43) for CSIA-AA analysis pre- and post-birth, alongside dietary and health surveys. RESULTS: Proline delta(15)N was elevated by 2.4 per thousand-3.5 per thousand in exclusively breastfed infants compared to their mothers and decreased by 2.2 per thousand-4.1 per thousand during weaning. Phenylalanine delta(15)N showed large positive shifts (e.g., by 6.7 per thousand) during maternal stress, despite being a source AA expected to remain stable. TP differences between mother-infant pairs were minimal (-0.2 to 0.1), except for one pair with higher infant TP (by 0.6-1.5). The calculated TEF(Glx-Phe) for infants ranged from -1.4 per thousand to 11.3 per thousand. DISCUSSION: Proline delta(15)N reliably tracks nutritional transitions, likely due to its role in arginine synthesis during infancy. The unexpected variability in delta(15)N(Phe) complicates its use in TP and dietary protein quality assessments. This variability may result from phenylalanine's slow turnover and delayed dietary incorporation during endogenous catabolism. TP is an unreliable marker of breastfeeding or weaning. TEF(Glx-Phe) for infants seems indicative of high dietary protein quality, but interpretations must consider the influence of non-dietary factors on delta(15)N(Phe). CI - (c) 2025 The Author(s). American Journal of Biological Anthropology published by Wiley Periodicals LLC. FAU - Salahuddin, Hana AU - Salahuddin H AUID- ORCID: 0009-0002-1444-211X AD - Anthropology, Western University, London, Canada. FAU - Waters-Rist, Andrea L AU - Waters-Rist AL AUID- ORCID: 0000-0003-1807-3171 AD - Anthropology, Western University, London, Canada. FAU - Longstaffe, Fred J AU - Longstaffe FJ AUID- ORCID: 0000-0003-4103-4808 AD - Earth Sciences, Western University, London, Canada. LA - eng GR - RGPIN 2019-05904/Natural Sciences and Engineering Research Council of Canada/ GR - X1277C01/Canada Research Chairs Program/ GR - Canada Foundation for Innovation/ GR - Ontario Research Fund/ GR - 767-2021-2823/Social Sciences and Humanities Research Council/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Am J Biol Anthropol JT - American journal of biological anthropology JID - 101770171 RN - 0 (Nitrogen Isotopes) RN - 0 (Amino Acids) RN - 0 (Dietary Proteins) RN - 68238-35-7 (Keratins) SB - IM MH - Humans MH - Female MH - Infant MH - *Nails/chemistry MH - *Nitrogen Isotopes/analysis MH - *Amino Acids/analysis MH - *Dietary Proteins/analysis MH - Male MH - Adult MH - Breast Feeding MH - *Diet MH - *Keratins/chemistry MH - *Stress, Physiological/physiology MH - Weaning MH - Infant, Newborn PMC - PMC12505251 OTO - NOTNLM OT - amino acids OT - breastfeeding and weaning OT - maternal illness OT - nitrogen isotopes OT - pregnancy COIS- The authors declare no conflicts of interest. EDAT- 2025/10/08 17:33 MHDA- 2025/10/08 17:34 PMCR- 2025/10/08 CRDT- 2025/10/08 06:13 PHST- 2025/08/09 00:00 [revised] PHST- 2025/04/10 00:00 [received] PHST- 2025/09/18 00:00 [accepted] PHST- 2025/10/08 17:34 [medline] PHST- 2025/10/08 17:33 [pubmed] PHST- 2025/10/08 06:13 [entrez] PHST- 2025/10/08 00:00 [pmc-release] AID - AJPA70128 [pii] AID - 10.1002/ajpa.70128 [doi] PST - ppublish SO - Am J Biol Anthropol. 2025 Oct;188(2):e70128. doi: 10.1002/ajpa.70128. PMID- 41058929 OWN - NLM STAT- MEDLINE DCOM- 20251010 LR - 20251120 IS - 2046-1402 (Electronic) IS - 2046-1402 (Linking) VI - 13 DP - 2024 TI - Standardised and Objective Dietary Intake Assessment Tool (SODIAT): Protocol of a dual-site dietary intervention study to integrate dietary assessment methods. PG - 1144 LID - 10.12688/f1000research.155683.2 [doi] LID - 1144 AB - INTRODUCTION: Current dietary assessment methods struggle to accurately capture individuals' dietary habits. The 'Standardised and Objective Dietary Intake Assessment Tool' (SODIAT)-1 study aims to assess the effectiveness of three emerging technologies (urine and capillary blood biomarkers, wearable camera technology) and two online self-reporting dietary assessment tools to monitor dietary intake. METHODS: This randomised controlled crossover trial was conducted at two sites (Hammersmith Hospital and the University of Reading) and aimed to recruit 30 UK participants (aged 18-70 years, BMI 20-30 kg/m (2)). Exclusion criteria included recent weight change, food allergies/intolerances, restrictive diets, certain health conditions and medication use. Volunteers completed an online screening questionnaire via REDCap and eligible participants attended a pre-study visit. Participants consumed, in a random order, two highly-controlled diets (compliant/non-compliant with UK guidelines) for four consecutive days, separated by at least one-week. Dietary intake was monitored daily using wearable cameras and self-recorded using Intake24 (24HR). Two versions of the online eNutri FFQ were completed: at baseline to assess habitual diet and on day 4 of each test period to record food intake. Urine and capillary blood samples were collected for biomarker analysis. Data analysis will assess dietary reporting accuracy across these methods using Lin's concordance correlation coefficient. DISCUSSION AND ETHICAL CONSIDERATIONS: The SODIAT project introduced a novel approach to dietary assessment, aiming to address the limitations like misreporting and inclusivity. However, challenges persist, such as variability in biomarker data due to failure to follow sample storage requirements and the practicalities of wearing cameras throughout the day. To protect privacy, participants removed cameras at inappropriate times, and AI removed non-food related images and blurred faces/device screens captured on the images. The accuracy of the tools in a highly-controlled setting will be evaluated in this study. Future studies are planned to validate these tools further in free-living and minority populations. CI - Copyright: (c) 2025 Bobokhidze E et al. FAU - Bobokhidze, Eka AU - Bobokhidze E AUID- ORCID: 0009-0000-3626-054X AD - Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, England, RG6 6DZ, UK. FAU - Weech, Michelle AU - Weech M AUID- ORCID: 0000-0003-1738-877X AD - Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, England, RG6 6DZ, UK. FAU - Petropoulou, Katerina AU - Petropoulou K AD - Section of Nutrition, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, England, W12 0NN, UK. FAU - Wilson, Thomas AU - Wilson T AUID- ORCID: 0000-0003-3112-4682 AD - Department of Life Sciences, Aberystwyth University, Aberystwyth, Wales, SY23 3DA, UK. FAU - Pugh, Jennifer AU - Pugh J AUID- ORCID: 0000-0002-5310-2882 AD - Section of Nutrition, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, England, W12 0NN, UK. FAU - Fallaize, Rosalind AU - Fallaize R AD - Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, England, RG6 6DZ, UK. AD - School of Life and Medical Sciences, University of Hertfordshire, Hatfield, England, AL 10 9AB, UK. FAU - Garcia-Perez, Isabel AU - Garcia-Perez I AD - Section of Nutrition, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, England, W12 0NN, UK. FAU - P-W Lo, Frank AU - P-W Lo F AD - The Hamlyn Centre for Robotic Surgery, Imperial College London, London, England, SW7 2AZ, UK. FAU - R Solis, Adrian AU - R Solis A AD - The Hamlyn Centre for Robotic Surgery, Imperial College London, London, England, SW7 2AZ, UK. FAU - Vickar, Juliet AU - Vickar J AUID- ORCID: 0000-0003-4019-3110 AD - Department of Life Sciences, Aberystwyth University, Aberystwyth, Wales, SY23 3DA, UK. FAU - Giannarou, Stamatia AU - Giannarou S AD - The Hamlyn Centre for Robotic Surgery, Imperial College London, London, England, SW7 2AZ, UK. FAU - Mylonas, George AU - Mylonas G AUID- ORCID: 0000-0003-3725-5843 AD - The Hamlyn Centre for Robotic Surgery, Imperial College London, London, England, SW7 2AZ, UK. FAU - Lo, Benny AU - Lo B AUID- ORCID: 0000-0002-5080-108X AD - The Hamlyn Centre for Robotic Surgery, Imperial College London, London, England, SW7 2AZ, UK. FAU - Lloyd, Amanda J AU - Lloyd AJ AUID- ORCID: 0000-0002-0775-3537 AD - Department of Life Sciences, Aberystwyth University, Aberystwyth, Wales, SY23 3DA, UK. FAU - Koulman, Albert AU - Koulman A AUID- ORCID: 0000-0001-9998-051X AD - Nutritional Biomarker Laboratory, MRC Epidemiology Unit, University of Cambridge, Cambridge, England, CB2 0QQ, UK. FAU - Beckmann, Manfred AU - Beckmann M AD - Department of Life Sciences, Aberystwyth University, Aberystwyth, Wales, SY23 3DA, UK. FAU - Draper, John AU - Draper J AD - Department of Life Sciences, Aberystwyth University, Aberystwyth, Wales, SY23 3DA, UK. FAU - Frost, Gary AU - Frost G AUID- ORCID: 0000-0003-0529-6325 AD - Section of Nutrition, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, England, W12 0NN, UK. FAU - Lovegrove, Julie A AU - Lovegrove JA AUID- ORCID: 0000-0001-7633-9455 AD - Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, England, RG6 6DZ, UK. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20250331 PL - England TA - F1000Res JT - F1000Research JID - 101594320 RN - 0 (Biomarkers) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - Biomarkers/blood/urine MH - Cross-Over Studies MH - *Diet MH - Feeding Behavior MH - *Nutrition Assessment MH - Randomized Controlled Trials as Topic MH - Self Report MH - Multicenter Studies as Topic PMC - PMC12498317 OTO - NOTNLM OT - Biomarkers OT - Dietary reporting OT - Health OT - Misreporting OT - Nutrition OT - Research OT - Underreporting COIS- Competing interests: JAL is Deputy Chair of the government's Scientific Advisory Committee on Nutrition (SACN) and a Member of the National Diet Nutrition Survey Project Board. GF has received educational funding for research from Nestle, Quorn Foods, Heptares and Unilever. He is also a director of the metabolomic spin out company Melico. AK receives financial support from Kingdom Department of Health and Social Care and contributes National Diet and Nutrition Survey Rolling Programme. IGP holds shares in Melico Sciences and is a director of the company. For all other authors, no competing interests were disclosed. EDAT- 2025/10/08 06:29 MHDA- 2025/10/08 06:30 PMCR- 2025/03/31 CRDT- 2025/10/08 05:26 PHST- 2025/03/21 00:00 [accepted] PHST- 2025/10/08 06:29 [pubmed] PHST- 2025/10/08 06:30 [medline] PHST- 2025/10/08 05:26 [entrez] PHST- 2025/03/31 00:00 [pmc-release] AID - 10.12688/f1000research.155683.2 [doi] PST - epublish SO - F1000Res. 2025 Mar 31;13:1144. doi: 10.12688/f1000research.155683.2. eCollection 2024. PMID- 41058080 OWN - NLM STAT- MEDLINE DCOM- 20260316 LR - 20260316 IS - 1945-7197 (Electronic) IS - 0021-972X (Linking) VI - 111 IP - 4 DP - 2026 Mar 17 TI - Development of a Machine Learning-based Model for Methimazole Dosage Adjustment in Youth With Hyperthyroidism. PG - e1136-e1145 LID - 10.1210/clinem/dgaf542 [doi] AB - CONTEXT: Accurate methimazole (MMI) dose adjustment in pediatric hyperthyroidism is crucial, but individualized titration relies on clinician experience due to a lack of validated predictive tools. OBJECTIVE: This study aimed to develop and validate machine learning-based models for predicting optimal MMI dosage in pediatric hyperthyroidism. DESIGN: This was a retrospective, multicenter, model-development study. Machine learning models, including linear regression, decision tree, support vector regression, Extreme Gradient Boosting (XGBoost), and feed-forward neural networks, were trained and validated. SETTING: Data were collected from a primary center for model training, with 2 separate centers providing data for external validation. PATIENTS OR OTHER PARTICIPANTS: Data were derived from 1512 visits for the training set and 666 and 31 visits for 2 external validation cohorts, respectively. All data were from youth aged 0.05), the 12-month pain prevalence was significantly higher in OSW, especially in the wrists (66% vs. 40%; p=0.035), where the most severe pain occurred (VAS 7.3/10). The use of painkillers was widespread among athletes and controls. Among Olympic weightlifters, the majority of cases involved self-medication. Frequent consumption was mainly found for ibuprofen (20%), acetylsalicylic acid (14%), and diclofenac (9%). The willingness to take part in competitions despite pain was widespread among the top athletes in our sample: 94% stated they would take part even if they needed to take painkillers. In contrast, only 9% reported that they would continue to participate even if their doctors advised against it. Therefore, doctors seem to act as gatekeepers and are most likely able to dissuade athletes from making such risky decisions. Among the athletes studied here at the highest national performance level, high 12-month prevalence rates for joint pain, widespread and, in some cases, prophylactic self-medication with painkillers were observed, along with a strong willingness to compete despite health complaints and pain. CI - Thieme. All rights reserved. FAU - Schneider, Sven AU - Schneider S AUID- ORCID: 0000-0001-6438-1971 AD - Center for Preventive Medicine and Digital Health, Universitat Heidelberg Medizinische Fakultat Mannheim, Mannheim, GERMANY. FAU - Horner, Helene AU - Horner H AD - German Joint Center Heidelberg, ATOS Praxisklinik Heidelberg: ATOS Klinik Heidelberg GmbH & Co KG, Heidelberg, GERMANY. FAU - Schmitt, Holger AU - Schmitt H AD - German Joint Center Heidelberg, ATOS Praxisklinik Heidelberg: ATOS Klinik Heidelberg GmbH & Co KG, Heidelberg, GERMANY. FAU - Berrsche, Gregor AU - Berrsche G AD - German Joint Center Heidelberg, ATOS Praxisklinik Heidelberg: ATOS Klinik Heidelberg GmbH & Co KG, Heidelberg, GERMANY. LA - eng PT - Journal Article TT - Pushing Limits - Die Bedeutung von Schmerzen und Schmerzmitteln im Olympischen Gewichtheben. DEP - 20251007 PL - Germany TA - Sportverletz Sportschaden JT - Sportverletzung Sportschaden : Organ der Gesellschaft fur Orthopadisch-Traumatologische Sportmedizin JID - 8904133 SB - IM COIS- The authors declare that they have no conflict of interest. EDAT- 2025/10/08 00:29 MHDA- 2025/10/08 00:29 CRDT- 2025/10/07 19:03 PHST- 2025/10/08 00:29 [medline] PHST- 2025/10/08 00:29 [pubmed] PHST- 2025/10/07 19:03 [entrez] AID - 10.1055/a-2693-5714 [doi] PST - aheadofprint SO - Sportverletz Sportschaden. 2025 Oct 7. doi: 10.1055/a-2693-5714. PMID- 41054870 OWN - NLM STAT- MEDLINE DCOM- 20251007 LR - 20251009 IS - 1532-2149 (Electronic) IS - 1090-3801 (Print) IS - 1090-3801 (Linking) VI - 29 IP - 10 DP - 2025 Nov TI - Associations of Graded Chronic Non-Cancer Pain Severity With Well-Being and Modifiable Lifestyle Behaviour: Findings From a Danish Population-Based Cross-Sectional Survey. PG - e70138 LID - 10.1002/ejp.70138 [doi] LID - e70138 AB - BACKGROUND: The Graded Chronic Pain Scale-Revised (GCPS-R) framework enables a standardised measure of disease severity and was incorporated into the national disease surveillance in Denmark in 2023. Novel dose-response associations between GCPS-R-systemised disease severity, general health, well-being, and modifiable lifestyle behaviour were analysed to enhance awareness of risk associations related to chronic non-cancer pain disease severity. METHODS: A cross-sectional study including 8329 non-cancer participants aged 16 years and older from the Danish National Health Survey 2023. The participants completed a comprehensive self-reported questionnaire on general health, well-being, and modifiable lifestyle behaviour, including the GCPS-R framework. Multivariate-adjusted odds ratios (OR) with 95% confidence intervals (95% CI) were calculated using logistic regression models for dichotomous outcomes related to general health, well-being, and modifiable lifestyle behaviour adjusted for sex, age, area of residence, BMI, country of origin, education and marital status. RESULTS: The GCPS-R score had strong positive dose-response associations with odds of poor/fair general health, showing ORs 1.66 (95% CI: 1.32-2.10) in mild-impact, 6.08 (5.02-7.37) in bothersome-impact, and 13.53 (11.53-15.88) in high-impact compared with no chronic non-cancer pain. The GCPS-R score had overall strong positive associations with odds of poor well-being outcomes and moderate positive associations with odds of unhealthy modifiable lifestyle behaviour outcomes concerning illicit drugs, obesity, sedentary lifestyle, unhealthy diet and tobacco. CONCLUSIONS: The GCPS-R framework is applicable in national surveys enabling graded measures for associations related to chronic non-cancer pain disease severity. Unified cross-country strategies for national surveillance could strengthen the evidence base for equitable public health policies. SIGNIFICANCE STATEMENT: Chronic non-cancer pain is a highly prevalent disease associated with elevated risks of several bio- psychosocial health conditions. However, whether risks related to chronic non-cancer pain vary by disease severity is currently unknown. Hellmann et al. found the validated GCPS-R framework useful in national survey-based disease surveillance. The GCPS-R-systemised disease severity measures classified in no, low-impact, bothersome-impact, and high-impact chronic non-cancer pain enabled nuanced knowledge about such risk associations, being a fundamental base in planning targeted healthcare strategies for improved chronic non-cancer pain management. CI - (c) 2025 The Author(s). European Journal of Pain published by John Wiley & Sons Ltd on behalf of European Pain Federation - EFIC (R). FAU - Hellmann, Sophie Sell AU - Hellmann SS AD - National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. FAU - Vaegter, Henrik Bjarke AU - Vaegter HB AD - Pain Research Group, Pain Center, Department of Anesthesiology and Intensive Care Medicine, University Hospital Odense, Odense, Denmark. AD - Department of Clinical Research, University of Southern Denmark, Odense, Denmark. FAU - Handberg, Gitte AU - Handberg G AD - Department of Anaesthesia and Intensive Care, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark. FAU - Petersen, Pernille Lykke AU - Petersen PL AD - Department of Anaesthesia and Intensive Care, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark. FAU - Kurita, Geana Paula AU - Kurita GP AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. AD - Department of Anaesthesiology, Pain and Respiratory Support, Pain and Palliative Care Research Group, Multidisciplinary Pain Centre, University Hospital Rigshospitalet, Copenhagen, Denmark. AD - Department of Oncology, Section of Palliative Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark. FAU - Sjogren, Per AU - Sjogren P AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. AD - St. Luke's Academy of Palliative Medicine, St. Lukes Foundation, Hellerup, Denmark. FAU - Thygesen, Lau Caspar AU - Thygesen LC AD - National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. FAU - Ekholm, Ola AU - Ekholm O AD - National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. LA - eng PT - Journal Article PL - England TA - Eur J Pain JT - European journal of pain (London, England) JID - 9801774 SB - IM MH - Humans MH - Male MH - Female MH - Denmark/epidemiology MH - Cross-Sectional Studies MH - Middle Aged MH - *Chronic Pain/psychology/epidemiology MH - Adult MH - Aged MH - *Life Style MH - Young Adult MH - Adolescent MH - Severity of Illness Index MH - Health Surveys MH - Pain Measurement MH - *Health Behavior PMC - PMC12501817 OTO - NOTNLM OT - GCPS-R OT - chronic pain OT - lifestyle OT - risk factors OT - well-being COIS- The authors declare no conflicts of interest. G.P.K. has received a research grant from the Novo Nordisk Foundation without relevance to the current research. EDAT- 2025/10/07 06:29 MHDA- 2025/10/07 06:30 PMCR- 2025/10/07 CRDT- 2025/10/07 05:13 PHST- 2025/08/29 00:00 [revised] PHST- 2025/07/16 00:00 [received] PHST- 2025/09/14 00:00 [accepted] PHST- 2025/10/07 06:30 [medline] PHST- 2025/10/07 06:29 [pubmed] PHST- 2025/10/07 05:13 [entrez] PHST- 2025/10/07 00:00 [pmc-release] AID - EJP70138 [pii] AID - 10.1002/ejp.70138 [doi] PST - ppublish SO - Eur J Pain. 2025 Nov;29(10):e70138. doi: 10.1002/ejp.70138. PMID- 41054865 OWN - NLM STAT- MEDLINE DCOM- 20251007 LR - 20260624 IS - 1945-7243 (Electronic) IS - 0046-9580 (Print) IS - 0046-9580 (Linking) VI - 62 DP - 2025 Jan-Dec TI - Salt Intake in Malaysia: A Population-Based Study of Knowledge, Attitudes, and Practices Among Adults. PG - 469580251375866 LID - 10.1177/00469580251375866 [doi] LID - 00469580251375866 AB - Excessive salt consumption has remained a critical public health issue in Malaysia where the average daily consumption has far exceeded the recommended limit by the World Health Organization (WHO). Driven by the cultural dietary patterns and limited public knowledge, it poses a significant challenge to attitudes, beliefs, and self-reported salt intake practices among Malaysian adults. This nationwide cross-sectional study was conducted from August to November 2023 using a multistage random sampling method.The study employed the validated MySalt Literacy instrument, designed to suit Malaysia's multicultural context and comprising domains on knowledge, beliefs, attitudes, practices, and salt intake among adults aged 18 years and older. A total of 4400 respondents participated in the study, with the majority being female (64.7%) and the remainder male (35.3%). Most respondents had attained tertiary education (54.2%) and resided in rural or semi-rural areas (55.7%). The study findings revealed only 30.9% of respondents correctly identified the recommended daily limit for salt intake, and 65.7% were unaware of the relationship between salt and sodium. In terms of behavioural practices, only 15.6% respondents reported actively limiting their daily salt intake, while merely 13.9% consistently paid attention to labels indicating "no salt added," "low," or "reduced sodium" when purchasing food. Further analysis indicated a significant correlation between attitudes, beliefs, and label-reading practices with salt intake behaviour. This study reveals that Malaysian adults are generally aware of the health risks due to excessive salt intake and express positive attitudes towards salt reduction, however significant knowledge gaps and cultural barriers impedes the progress. Thus, efforts to reduce salt intake must go beyond raising awareness by addressing cultural beliefs, taste preferences and behavioural habits. Effective interventions should incorporate culturally tailored strategies and relatable messages that consider taste preferences and behavioural norms. A coordinated, multi sectoral approach involving health promotion, nutrition education (including label-reading skills), and food policy reforms such as front of pack labelling and mandatory reformulation is essential for sustainable, population wide salt reduction. FAU - Perialathan, Komathi AU - Perialathan K AUID- ORCID: 0000-0003-3539-8605 AD - Ministry of Health Malaysia, Setia Alam, Selangor, Malaysia. FAU - Azamuddin, Ain Aqiela AU - Azamuddin AA AUID- ORCID: 0009-0008-0747-2947 AD - Ministry of Health Malaysia, Setia Alam, Selangor, Malaysia. FAU - Yong, Teresa Sui Mien AU - Yong TSM AUID- ORCID: 0000-0003-4102-321X AD - Ministry of Health Malaysia, Setia Alam, Selangor, Malaysia. FAU - Krishnan, Manimaran AU - Krishnan M AD - Ministry of Health Malaysia, Setia Alam, Selangor, Malaysia. FAU - Ahmad, Masitah AU - Ahmad M AUID- ORCID: 0000-0002-7551-3877 AD - Ministry of Health Malaysia, Setia Alam, Selangor, Malaysia. FAU - Johari, Mohammad Zabri AU - Johari MZ AUID- ORCID: 0000-0002-8017-622X AD - Ministry of Health Malaysia, Setia Alam, Selangor, Malaysia. FAU - Mohamad, Hamdan Bin AU - Mohamad HB AD - Ministry of Health Malaysia, Putrajaya, Malaysia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251007 PL - United States TA - Inquiry JT - Inquiry : a journal of medical care organization, provision and financing JID - 0171671 RN - 0 (Sodium Chloride, Dietary) SB - IM EIN - Inquiry. 2026 Jan-Dec;63:469580261450809. doi: 10.1177/00469580261450809. PMID: 42339775 MH - Humans MH - Malaysia MH - Male MH - Female MH - Adult MH - *Health Knowledge, Attitudes, Practice MH - Cross-Sectional Studies MH - Middle Aged MH - *Sodium Chloride, Dietary/administration & dosage MH - Young Adult MH - Surveys and Questionnaires MH - Adolescent MH - Aged PMC - PMC12504836 OTO - NOTNLM OT - attitude OT - belief OT - dietary salt OT - knowledge OT - practice OT - sodium COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/10/07 06:29 MHDA- 2025/10/07 06:30 PMCR- 2025/10/07 CRDT- 2025/10/07 05:12 PHST- 2025/10/07 06:30 [medline] PHST- 2025/10/07 06:29 [pubmed] PHST- 2025/10/07 05:12 [entrez] PHST- 2025/10/07 00:00 [pmc-release] AID - 10.1177_00469580251375866 [pii] AID - 10.1177/00469580251375866 [doi] PST - ppublish SO - Inquiry. 2025 Jan-Dec;62:469580251375866. doi: 10.1177/00469580251375866. Epub 2025 Oct 7. PMID- 41053884 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251007 LR - 20251009 IS - 1743-7075 (Print) IS - 1743-7075 (Electronic) IS - 1743-7075 (Linking) VI - 22 IP - 1 DP - 2025 Oct 6 TI - Choosing sweeteners wisely-nutrigenetic study on childhood obesity. PG - 114 LID - 10.1186/s12986-025-01015-x [doi] LID - 114 AB - BACKGROUND: This study investigated the association of specific sweet-taste and obesity-related genes with sweetener consumption patterns among children and the interaction between these genetic factors and sweetener intake on the risk of childhood obesity. By leveraging data from the Taiwanese Pubertal Longitudinal Study (TPLS), the current study minimized the influence of environmental confounders commonly encountered in adult studies, offering a more precise understanding of these relationships in pediatric and adolescent populations. METHODS: Participants in the TPLS underwent genetic sampling, anthropometric measurements, puberty stage assessments, dietary recall, and measurements of relevant lifestyle variables. Nonnutritive sweetener (NNS) intake was assessed using the validated Nonnutritive Sweetener Food Frequency Questionnaire (NNS-FFQ). The statistical analysis employs logistic regression to investigate the correlations between genotypes and sweetener consumption, while accounting for potential confounders such as parental education and household income. Simultaneously, the study examines gene-sweetener interactions to assess the association between specific alleles and particular sweetener consumption patterns. RESULTS: Higher consumption of specific artificial sweeteners-acesulfame potassium, sucralose, and steviol-was associated with lower body mass index (BMI) Z-scores and reduced body fat percentage. The interaction analyses indicated a significantly positive association of the interaction between sucralose consumption and sweet-taste genes on the waist-hip ratio. Genetic analysis revealed significant associations between obesity-related genes (e.g., ADCY9 and TFAP2B) and sweet-taste receptor genes (e.g., TAS1R2 and TAS1R3) with sweetener consumption, which may influence susceptibility to obesity. Notably, rs7498665 was significantly associated with BMI Z-scores, underscoring its role in obesity predisposition. CONCLUSIONS: These findings highlight the genetic underpinnings of sweetener consumption and its interactive effects with genetic variants on childhood obesity risk, providing valuable insights for promoting public health and developing personalized nutrition strategies. Future research involving larger samples and consideration of genetic and environmental factors is required to develop personalized nutrition strategies aimed at effectively combating childhood obesity. CI - (c) 2025. The Author(s). FAU - Qiu, Daniel Wang AU - Qiu DW AD - College of Medicine, Taipei Medical University, Taipei, Taiwan. FAU - Kuo, Chia-Min AU - Kuo CM AD - Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. FAU - Hsu, Shih-Yuan AU - Hsu SY AD - Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. FAU - Su, Emily Chia-Yu AU - Su EC AD - Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei, Taiwan. FAU - Wang, San-Yuan AU - Wang SY AD - Master Program in Clinical Genomics and Proteomics, Department of Pharmaceutical Sciences, Taipei Medical University, Taipei, Taiwan. FAU - Hou, Jia-Woei AU - Hou JW AD - Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan. AD - College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan. FAU - Tsai, Meng-Che AU - Tsai MC AD - Department of Pediatrics, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan. FAU - Yang, Chen AU - Yang C AD - Department of Pediatrics, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan. AD - Ihmed Children Healthcare Center, Taipei, Taiwan. FAU - Chen, Yang-Ching AU - Chen YC AD - Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. melisa26@tmu.edu.tw. AD - Department of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei Medical University, Taipei 116, Taiwan, No. 111 Section 3, Xing-long Road, Wenshan District, Taipei, 11696, Taiwan R.O.C.. melisa26@tmu.edu.tw. AD - School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan. melisa26@tmu.edu.tw. AD - Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, Taiwan. melisa26@tmu.edu.tw. AD - Nutrition Research Center, Taipei Medical University Hospital, Taipei, Taiwan. melisa26@tmu.edu.tw. LA - eng PT - Journal Article DEP - 20251006 PL - England TA - Nutr Metab (Lond) JT - Nutrition & metabolism JID - 101231644 PMC - PMC12502141 OTO - NOTNLM OT - Childhood obesity OT - Cohort study OT - Dietary preference OT - Gene-nutrient interaction COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/10/07 06:30 MHDA- 2025/10/07 06:31 PMCR- 2025/10/06 CRDT- 2025/10/07 00:12 PHST- 2025/01/09 00:00 [received] PHST- 2025/09/09 00:00 [accepted] PHST- 2025/10/07 06:31 [medline] PHST- 2025/10/07 06:30 [pubmed] PHST- 2025/10/07 00:12 [entrez] PHST- 2025/10/06 00:00 [pmc-release] AID - 10.1186/s12986-025-01015-x [pii] AID - 1015 [pii] AID - 10.1186/s12986-025-01015-x [doi] PST - epublish SO - Nutr Metab (Lond). 2025 Oct 6;22(1):114. doi: 10.1186/s12986-025-01015-x. PMID- 41053755 OWN - NLM STAT- MEDLINE DCOM- 20251007 LR - 20251114 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Oct 6 TI - Nutritional knowledge and dietary practices among young Arab adults: disparities and predictors. PG - 3361 LID - 10.1186/s12889-025-24702-z [doi] LID - 3361 AB - BACKGROUND: Nutritional knowledge and practices are crucial factors contributing to overall health in populations. However, a disconnect between nutritional knowledge and healthy dietary habits has been noted in the literature, particularly among younger adults. Thus, the study aims to assess nutritional knowledge and practices among young adults across selected Arab countries. METHODS: The cross-sectional study was conducted among young Arab aged between 18 and 25 years living in Egypt, Iraq, Jordan, Maghreb Arab countries (Morocco, Algeria, and Tunisia), Saudi Arabia, and Sudan. Data were collected using a validated questionnaire. RESULTS: In total, 2,582 participants were included in the study, 20% of whom live in Iraq and 20% in Saudi Arabia. Most female participants (29.46%) were from Saudi Arabia, whereas male participants were primarily from Egypt (35.40%). The findings indicated that 43.38% of the sample had a satisfactory level of knowledge about healthy diets, while 24.05% had a poor level of knowledge. In addition, most of the sample demonstrated unhealthy dietary habits (42.06%), with the highest percentage (55.99%) observed among participants residing in Saudi Arabia. Factors including age, gender, marital status, and country of residence were found associated with the healthiness of dietary practices. CONCLUSION: Nutritional knowledge varied across different Arab countries, and dietary patterns showed significant differences among the countries included in the study. CI - (c) 2025. The Author(s). FAU - Alzaben, Abeer Salman AU - Alzaben AS AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia. FAU - Mahboub, Samira AU - Mahboub S AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia. FAU - Almoayad, Fatmah AU - Almoayad F AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia. FAU - Benajiba, Nada AU - Benajiba N AD - Unite Mixte de Recherche en Nutrition et Alimentation URAC 39, Universite Ibn Tofail-CNESTEN), RDC-Nutrition, Kenitra, Morocco. FAU - Alabdulkader, Shahd AU - Alabdulkader S AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia. FAU - Bakry, Huny M AU - Bakry HM AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia. FAU - Alkilani, Laila AU - Alkilani L AD - Department of Physical Sport Sciences, College of Sport Sciences & Physical Activity, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia. FAU - Abusalih, Howeida H AU - Abusalih HH AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia. FAU - Hussein, Yasir Najah AU - Hussein YN AD - Collage of Physical Education and Sport Sciences, University of Baghdad, Baghdad, Iraq. FAU - Bawazeer, Nahla Mohammed AU - Bawazeer NM AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia. NMBawazeer@pnu.edu.sa. LA - eng GR - PNURSP2025R369/Deanship of Scientific Research, Princess Nourah Bint Abdulrahman University/ PT - Journal Article DEP - 20251006 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Male MH - Female MH - *Arabs/statistics & numerical data/psychology MH - Cross-Sectional Studies MH - *Health Knowledge, Attitudes, Practice MH - Young Adult MH - Adult MH - Adolescent MH - Surveys and Questionnaires MH - *Feeding Behavior MH - Middle East MH - *Diet MH - *Diet, Healthy PMC - PMC12502298 OTO - NOTNLM OT - Arabs OT - Dietary pattern OT - Dietary practices OT - Knowledge OT - Nutrition OT - Young adults COIS- Declarations. Ethics approval and consent to participate: The study protocol was reviewed by the Institutional Review Board (IRB) of Princess Nourah bint Abdulrahman University (IRB approval number: 22-0406), and consent was obtained from all participants prior to taking the questionnaire. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/10/07 00:29 MHDA- 2025/10/07 06:30 PMCR- 2025/10/06 CRDT- 2025/10/07 00:01 PHST- 2024/05/18 00:00 [received] PHST- 2025/08/29 00:00 [accepted] PHST- 2025/10/07 06:30 [medline] PHST- 2025/10/07 00:29 [pubmed] PHST- 2025/10/07 00:01 [entrez] PHST- 2025/10/06 00:00 [pmc-release] AID - 10.1186/s12889-025-24702-z [pii] AID - 24702 [pii] AID - 10.1186/s12889-025-24702-z [doi] PST - epublish SO - BMC Public Health. 2025 Oct 6;25(1):3361. doi: 10.1186/s12889-025-24702-z. PMID- 41053679 OWN - NLM STAT- MEDLINE DCOM- 20251007 LR - 20260614 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 25 IP - 1 DP - 2025 Oct 6 TI - Growth impairment in glycogen storage disease type I versus types III/VI/IX: a cross-sectional study. PG - 773 LID - 10.1186/s12887-025-06053-1 [doi] LID - 773 AB - BACKGROUND: Growth retardation is common in glycogen storage disease (GSD), though the relative contributions of hormonal and metabolic factors remain unclear. We compared clinical and biochemical features between GSD I and non-GSD I patients and identified independent predictors of height standard deviation score (SDS). METHODS: Thirty-eight children with GSD (24 with GSD I; 14 with GSD III/VI/IX; mean age: 7.5 years) underwent evaluation of height SDS, BMI SDS, IGF1 SDS, and metabolic parameters. After excluding three patients with inflammatory bowel disease (final n = 35), multiple regression was used to identify factors associated with height SDS. In GSD I (n = 24), Lasso regression selected variables, and 1,000 bootstrap resamples assessed coefficient stability. RESULTS: GSD I patients had lower height SDS (-2.30 vs. - 1.17; p = 0.021) and higher lactate (3.94 vs. 1.48 mmol/L; p < 0.001), uric acid (431.04 vs. 283.79micromol/L; p < 0.001) and triglyceride levels (2.38 vs. 1.29 mmol/L, p = 0.002) compared to non-GSD I. In combined-cohort regression, lactate was the only independent negative predictor of height SDS (p = 0.011); glucose levels and IGF1 SDS did not reach statistical significance. In GSD I, Lasso retained lactate (beta = - 0.682), glucose (beta = - 0.625), and IGF1 SDS (beta = 0.524), and bootstrap validation showed only IGF1 SDS remained consistently significant. CONCLUSIONS: Hyperlactatemia is significant predictor of growth impairment in GSD, while IGF1 is a stable predictor in GSD I. These findings highlight metabolic and hormonal targets for future hypothesis-driven research in this population. CI - (c) 2025. The Author(s). FAU - Wu, Xiaohui AU - Wu X AD - Department of Pediatrics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China. FAU - Sun, Yueyu AU - Sun Y AD - Department of Pediatrics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China. sunyueyu@sina.com. FAU - Yang, Min AU - Yang M AD - Department of Pediatrics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China. yangmin1008@gdph.org.cn. LA - eng PT - Comparative Study PT - Journal Article DEP - 20251006 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 RN - 67763-96-6 (Insulin-Like Growth Factor I) RN - 0 (Triglycerides) RN - 0 (IGF1 protein, human) RN - 33X04XA5AT (Lactic Acid) RN - Hepatorenal form of glycogen storage disease SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Female MH - Child MH - *Glycogen Storage Disease Type I/complications/blood MH - Child, Preschool MH - *Growth Disorders/etiology/blood MH - Insulin-Like Growth Factor I/metabolism/analysis MH - Body Height MH - *Glycogen Storage Disease/complications/blood MH - Adolescent MH - Body Mass Index MH - Triglycerides/blood MH - *Glycogen Storage Disease Type III/complications/blood MH - Lactic Acid/blood PMC - PMC12502152 OTO - NOTNLM OT - Glycogen storage disease (GSD) OT - Growth Impairment OT - IGF1 (Insulin-like Growth Factor 1) OT - Pediatric EndocrinologyMetabolic DisordersRare Genetic Disorders COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the principle of the Declaration of Helsinki and approved by the Institutional Review Board (IRB) of Guangdong Provincial People's Hospital. Written informed consent was obtained from all participants or their legal guardians prior to their inclusion in the study. Participants were informed about the purpose of the study, the voluntary nature of their participation, and their right to withdraw at any time without consequence. All patient data were anonymized to ensure confidentiality. Consent for publication: All participants or their legal guardians provided written informed consent for the publication of their clinical data and results as part of this study. No personal identifiers are included in this manuscript, and all data have been anonymized to protect the privacy of the participants. Competing interests: The authors declare no competing interests. EDAT- 2025/10/07 00:29 MHDA- 2025/10/07 06:29 PMCR- 2025/10/06 CRDT- 2025/10/06 23:56 PHST- 2025/03/15 00:00 [received] PHST- 2025/08/11 00:00 [accepted] PHST- 2025/10/07 06:29 [medline] PHST- 2025/10/07 00:29 [pubmed] PHST- 2025/10/06 23:56 [entrez] PHST- 2025/10/06 00:00 [pmc-release] AID - 10.1186/s12887-025-06053-1 [pii] AID - 6053 [pii] AID - 10.1186/s12887-025-06053-1 [doi] PST - epublish SO - BMC Pediatr. 2025 Oct 6;25(1):773. doi: 10.1186/s12887-025-06053-1. PMID- 41051395 OWN - NLM STAT- MEDLINE DCOM- 20260306 LR - 20260306 IS - 2769-707X (Electronic) IS - 2769-7061 (Linking) VI - 45 IP - 3 DP - 2026 Mar-Apr TI - Validation of the Korean Version of the Nutrition Screening Tool for Every Preschooler (NutriSTEP((R))): Using the Rasch Model. PG - 280-291 LID - 10.1080/27697061.2025.2566750 [doi] AB - OBJECTIVE: Assessing the nutrition risk of preschoolers is crucial for promoting their healthy growth and development. This study aimed to develop a Korean version of NutriSTEP((R)) by assessing its feasibility, validity, and reliability. METHODS: A quantitative cross-sectional study was conducted with parents of preschoolers aged 3-6 years. Five scholars independently translated the English version of NutriSTEP((R)) into Korean. One-on-one online cognitive interviews were conducted with 10 parents, and an expert panel review with the five scholars was conducted using an item content validity index. A total of 201 parents participated in an online survey, and the criterion validity of NutriSTEP((R)) was assessed using receiver operating characteristic (ROC) curves. Construct validity was examined through item analysis using the Rasch model and known-groups validity, while internal consistency was assessed using the test-retest reliability. RESULTS: Eight items were revised to improve cultural acceptability and comprehensibility. Each item of NutriSTEP((R)) had an Item-content validity index (I-CVI) of 1.0, and the area under the curve for the ROC curve was 90.5%. A cut-point of NutriSTEP((R)) score to determine moderate risk (> 25) had a sensitivity of 90.5% and specificity of 71.7%, compared to the moderate nutrition risk (>/= 5). The Korean version of NutriSTEP((R)) was unidimensional, and scores varied significantly based on parents' income levels (F = 11.154, p < .001) and children's physical activity levels (t = -4.107, p < .001). The test-retest reliability was .661. CONCLUSION: This study confirms that NutriSTEP((R)) is a valid and reliable tool for assessing Korean preschooler's nutrition risk. Using NutriSTEP((R)) could offer valuable insights for promoting healthy dietary behaviors in preschoolers. FAU - Park, So Hyun AU - Park SH AUID- ORCID: 0000-0002-2199-7984 AD - Red Cross College of Nursing, Chung-Ang University, Seoul, Republic of Korea. AD - College of Nursing, Florida State University, Tallahassee, FL, United States. FAU - Son, Youn-Jung AU - Son YJ AUID- ORCID: 0000-0002-0961-9606 AD - Red Cross College of Nursing, Chung-Ang University, Seoul, Republic of Korea. FAU - Park, Hanjong AU - Park H AUID- ORCID: 0000-0003-0896-654X AD - College of Nursing, The Catholic University of Korea, Seoul, Republic of Korea. LA - eng PT - Journal Article PT - Validation Study DEP - 20251006 PL - United States TA - J Am Nutr Assoc JT - Journal of the American Nutrition Association JID - 9918300687506676 SB - IM MH - Humans MH - Child, Preschool MH - Male MH - Female MH - Reproducibility of Results MH - Cross-Sectional Studies MH - Republic of Korea MH - Child MH - *Nutrition Assessment MH - Parents MH - *Nutritional Status MH - Surveys and Questionnaires MH - ROC Curve OTO - NOTNLM OT - NutriSTEP(R) OT - nutrition assessment OT - parents OT - preschool children OT - psychometrics EDAT- 2025/10/06 12:31 MHDA- 2026/03/06 19:43 CRDT- 2025/10/06 10:53 PHST- 2026/03/06 19:43 [medline] PHST- 2025/10/06 12:31 [pubmed] PHST- 2025/10/06 10:53 [entrez] AID - 10.1080/27697061.2025.2566750 [doi] PST - ppublish SO - J Am Nutr Assoc. 2026 Mar-Apr;45(3):280-291. doi: 10.1080/27697061.2025.2566750. Epub 2025 Oct 6. PMID- 41049885 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251006 LR - 20260925 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 8 IP - 10 DP - 2025 Oct TI - Development and Validation of a Predictive Model for Individual Risk Prediction of Stunting in Ethiopia: A Predictive Modeling Study. PG - e71335 LID - 10.1002/hsr2.71335 [doi] LID - e71335 AB - BACKGROUND AND AIMS: Stunting is a height for age Z score falls bellow -2 standard deviation. Untreated stunted cases have lifelong consequences like cognitive development, increased risk of infection and long-term health and economy burden. Although stunting remains highly prevalent in Ethiopia, there has been no prior attempt to develop an individualized risk prediction model. This study will develop and validates a predictive model to improve targeted intervention in Ethiopia. METHODS: Data from 2019 Mini Ethiopian Demographic Health Survey comprised of 2079 children's below 2 years. Data analysis was done using STATA version 17 and R version 4.4.1 software. Least absolute shrinkage and selection operator were used to select variables for Multilevel Multivariable Analysis. Nomogram was developed and model's performance was assessed through the area under the receiver operating characteristic curve and calibration plots. Bootstrapping techniques were applied to internally validate the accuracy of the model. Additionally, decision curve analysis was conducted to examine its clinical and public health applicability. RESULTS: The prevalence of stunting was 27.8% [95% CI: 24.96, 30.89]. The developed nomogram comprised 8 predictors: Maternal education, residence, sex a child, age of a child, Current feeding status, usage of bottle feeding, twin status and marital status. The area under the receiver operating characteristic curve of the original model was (AUC = 0.722, 95% CI; 0.698, 0.747) whereas the after bootstrap model produced prediction accuracy of an AUC of 0.719 (95% CI; 0.693, 0.744). Internal validation was performed using the bootstrapping method, demonstrating reasonably corrected discriminative ability. Decision curve analysis showed that the model provided a greater net benefit than strategies of treating all or none, particularly for threshold probabilities exceeding 19%. CONCLUSION: This study developed and internally validated a predictive model for stunting in children under 2 years in Ethiopia, with strong discriminatory power (AUC 0.729) and calibration. The model, incorporating eight key predictors, offers a practical tool for clinical decision-making through a user-friendly nomogram. CI - (c) 2025 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Ahmed, Ahmed Fentaw AU - Ahmed AF AUID- ORCID: 0009-0000-2340-8322 AD - Department of Public Health, College of Medicine and Health Sciences Injibara University Injibara Ethiopia. FAU - Yosef, Tewodros AU - Yosef T AUID- ORCID: 0000-0002-3173-6753 AD - School of Public Health, College of Medicine and Health Sciences Mizan-Tepi University Mizan Teferi Ethiopia. FAU - Asfaw, Cherugeta Kebede AU - Asfaw CK AUID- ORCID: 0009-0008-6055-1089 AD - Department of Internal Medicine, School of Medicine, College of Medicine and Health Science Selale University Fitche Ethiopia. FAU - Weldeyes, Eyob Girum AU - Weldeyes EG AUID- ORCID: 0009-0000-6433-6425 AD - Department of Medicine, College of Medicine and Health Sciences Selale University Fitche Ethiopia. FAU - Cherinet, Eskindir Melese AU - Cherinet EM AUID- ORCID: 0009-0001-9070-5228 AD - Department of Intensive Care Fik Primary Hospital Somali Ethiopia. FAU - Oumer, Mohamed Abdu AU - Oumer MA AUID- ORCID: 0009-0006-8875-1715 AD - Clinical Governance and Quality Unit Kebribeyah Primary Hospital Kebribeyah Ethiopia. FAU - Assefa, Filimon Getaneh AU - Assefa FG AUID- ORCID: 0009-0005-5933-4712 AD - Department of Medicine, College of Medicine and Health Sciences Dilla University Dilla Ethiopia. FAU - Tadege, Tinsae Tesfaw AU - Tadege TT AUID- ORCID: 0009-0003-5977-4537 AD - Department of Medicine, College of Medicine and Health Sciences University of Gondar Gondar Ethiopia. FAU - Sileshi, Biniyam Mequanent AU - Sileshi BM AUID- ORCID: 0009-0003-6363-8423 AD - Department of Medicine, College of Medicine and Health Sciences University of Gondar Gondar Ethiopia. FAU - Yimer, Eyob Getaneh AU - Yimer EG AUID- ORCID: 0009-0006-7548-278X AD - Department of Medicine, College of Medicine and Health Sciences University of Gondar Gondar Ethiopia. FAU - Ebrahim, Fuad Seid AU - Ebrahim FS AUID- ORCID: 0009-0001-9521-8285 AD - Worabe Comprehensive Specialized Hospital Worabe Ethiopia. FAU - Abegaz, Bemnet Yazew AU - Abegaz BY AUID- ORCID: 0000-0001-8920-0516 AD - Department of Internal Medicine, School of Medicine College of Medicine and Health Sciences Wollo University Dese Ethiopia. FAU - Sharew, Kalaab Esubalew AU - Sharew KE AUID- ORCID: 0000-0001-5524-7754 AD - Department of Internal Medicine, School of Medicine, College of Medicine and Health Science Injibara University Injibara Ethiopia. LA - eng PT - Journal Article DEP - 20251003 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC12491992 OTO - NOTNLM OT - Ethiopia OT - children OT - prediction OT - risk score OT - stunting COIS- The authors declare no conflicts of interest. EDAT- 2025/10/06 12:31 MHDA- 2025/10/06 12:32 PMCR- 2025/10/03 CRDT- 2025/10/06 07:28 PHST- 2025/03/17 00:00 [received] PHST- 2025/08/21 00:00 [revised] PHST- 2025/08/28 00:00 [accepted] PHST- 2025/10/06 12:32 [medline] PHST- 2025/10/06 12:31 [pubmed] PHST- 2025/10/06 07:28 [entrez] PHST- 2025/10/03 00:00 [pmc-release] AID - HSR271335 [pii] AID - 10.1002/hsr2.71335 [doi] PST - epublish SO - Health Sci Rep. 2025 Oct 3;8(10):e71335. doi: 10.1002/hsr2.71335. eCollection 2025 Oct. PMID- 41049326 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251006 LR - 20251008 IS - 0001-7019 (Print) IS - 1846-0410 (Electronic) IS - 0001-7019 (Linking) VI - 59 IP - 3 DP - 2025 Sep TI - A Cross-Sectional Study of Parental Knowledge, Practices, and Predictors of Child Oral Health Behaviors and Fear in Zagreb, Croatia. PG - 262-275 LID - 10.15644/asc59/3/4 [doi] AB - OBJECTIVE: This study aimed to evaluate parental knowledge, behaviors, and sociodemographic predictors influencing children's oral hygiene practices, dental visitation patterns, and dental fear in Croatia. MATERIALS AND METHODS: A cross-sectional study involving 100 parents of children aged 0-7 years was conducted at the Department of Pediatric and Preventive Dentistry, School of Dental Medicine, University of Zagreb. A structured, validated questionnaire assessed parental knowledge, dietary habits, brushing frequency, fluoride use, dental visit reasons and frequency, and child dental fear. Statistical analyses included chi-square tests, ANOVA, Spearman correlations, and logistic regression to identify predictors of inadequate oral hygiene, irregular dental attendance, and dental fear. RESULTS: Only 68% of children brushed their teeth twice a day; 66% consumed sweets daily, and 33.3% drank sweetened beverages daily. Logistic regression revealed that brushing once per day or less-classified as inadequate brushing-was significantly predicted by daily consumption of snacks (OR = 2.91, p = 0.025) and low parental oral health knowledge (OR = 2.58, p = 0.043). Irregular dental visits were more likely in children with a history of dental pain (OR=3.42, p=0.019). Child dental fear (41.4%) was predicted by previous trauma (OR=26.4, p=0.001), frequent check-ups (OR=27.4, p=0.009), and parental education (OR=10.0, p=0.049), while trauma management knowledge was protective (OR=0.067, p=0.002). Fluoridated toothpaste use was positively associated with regular dental attendance. CONCLUSIONS: Children's oral health behaviors and fear are significantly influenced by parental knowledge, education, dietary patterns, and trauma experiences. Educational interventions targeting caregivers, particularly regarding trauma response and oral hygiene, are warranted to improve pediatric oral health outcomes. CI - University of Zagreb School of Dental Medicine. FAU - Kolaric, Sanja AU - Kolaric S AUID- ORCID: 0009-0009-7288-1357 AD - University Hospital Center Zagreb, Department of Dentistry, Department of Pediatric and Preventive Dentistry, Zagreb, Croatia. FAU - Vuckovic-Hrkac, Sanja AU - Vuckovic-Hrkac S AUID- ORCID: 0009-0009-2967-2007 AD - University Hospital Center Zagreb, Department of Dentistry, Department of Orthodontics, Zagreb, Croatia. AD - University of Zagreb School of Dental Medicine, Department of Orthodontics, Zagreb, Croatia. FAU - Simunovic, Luka AU - Simunovic L AUID- ORCID: 0000-0003-2848-6041 AD - University of Zagreb School of Dental Medicine, Department of Orthodontics, Zagreb, Croatia. FAU - Negovetic-Vranic, Dubravka AU - Negovetic-Vranic D AUID- ORCID: 0000-0001-7632-2004 AD - University Hospital Center Zagreb, Department of Dentistry, Department of Pediatric and Preventive Dentistry, Zagreb, Croatia. AD - University of Zagreb School of Dental Medicine, Department of Pediatric and Preventive Dentistry, Zagreb, Croatia. FAU - Verzak, Zeljko AU - Verzak Z AUID- ORCID: 0000-0002-5875-517X AD - University Hospital Center Zagreb, Department of Dentistry, Department of Pediatric and Preventive Dentistry, Zagreb, Croatia. AD - University of Zagreb School of Dental Medicine, Department of Pediatric and Preventive Dentistry, Zagreb, Croatia. FAU - Majer, Marjeta AU - Majer M AUID- ORCID: 0000-0001-5494-8719 AD - University of Zagreb School of Medicine, School of Public Health "Andrija Stampar", Department of Social Medicine and Organization of Health Care, Zagreb, Croatia. LA - eng PT - Journal Article PL - Croatia TA - Acta Stomatol Croat JT - Acta stomatologica Croatica JID - 0253456 PMC - PMC12490699 OTO - NOTNLM OT - Child OT - Dental Anxiety OT - Dental Caries OT - Health Knowledge Attitudes Practice OT - MeSH Terms: Oral Health OT - Oral Health OT - Oral Hygiene OT - Parent-Child Relations OT - Parental Knowledge OT - Parents OT - Pediatric Dentistry COIS- Conflict of interest: The authors declare no conflicts of interest regarding this manuscript. EDAT- 2025/10/06 12:31 MHDA- 2025/10/06 12:32 PMCR- 2025/09/01 CRDT- 2025/10/06 07:20 PHST- 2025/04/04 00:00 [received] PHST- 2025/07/23 00:00 [accepted] PHST- 2025/10/06 12:32 [medline] PHST- 2025/10/06 12:31 [pubmed] PHST- 2025/10/06 07:20 [entrez] PHST- 2025/09/01 00:00 [pmc-release] AID - ASC_59-3_262-275 [pii] AID - 10.15644/asc59/3/4 [doi] PST - ppublish SO - Acta Stomatol Croat. 2025 Sep;59(3):262-275. doi: 10.15644/asc59/3/4. PMID- 41049068 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251006 LR - 20251008 IS - 1178-7031 (Print) IS - 1178-7031 (Electronic) IS - 1178-7031 (Linking) VI - 18 DP - 2025 TI - Establishment and Validation of a Novel Nutritional-Immune-Inflammatory Score Model for Predicting Survival Prognosis in Hepatocellular Carcinoma Patients Treated with PD-1 Inhibitors. PG - 13397-13412 LID - 10.2147/JIR.S546164 [doi] AB - PURPOSE: Immune checkpoint inhibitors, particularly PD-1 inhibitors, are widely used in hepatocellular carcinoma therapy, many received PD-1 inhibitors beyond first-line, but heterogeneous treatment responses require reliable biomarkers. The interaction of immune function, nutritional status, and inflammatory responses affects tumor progression and survival, yet their prognostic value in PD-1 inhibitor-treated HCC patients remains unclear. This study developed a novel nutritional-immune-inflammatory score (NIIS) to evaluate its prognostic value in HCC patients receiving PD-1 inhibitors. PATIENTS AND METHODS: We analyzed 355 HCC patients treated with PD-1 inhibitors (training: n=249; validation: n=106), the cohort included 18.6% Child-Pugh B patients. Fourteen nutritional, immune, and inflammatory biomarkers were evaluated. Prognostic indicators were selected via univariate and LASSO Cox regression. The NIIS was constructed and validated for OS prediction. A nomogram integrating the NIIS with clinical variables was developed and validated based on calibration curves, AUC, and DCA, and compared with the BCLC staging system. The primary outcome assessed was OS from the initiation of PD-1 inhibitor therapy in HCC patients. RESULTS: The NIIS (ALRI, APRI, PALBI, AAPR) showed strong prognostic stratification. High-risk patients had shorter OS (training: P =1.764x10;-8; verification: P=2.775x10;-6). Higher NIIS were significantly associated with advanced tumor stage, poor liver function grade, multiple and larger tumors, tumor thrombus, vascular invasion, and elevated AFP levels (P<0.05). Multivariate Cox analysis confirmed the NIIS as an independent prognostic factor for OS (training: HR=1.565, 95% CI: 1.273-1.925; verification: HR=1.341, 95% CI: 1.065-1.687). A nomogram integrating the NIIS with clinical variables was constructed for individualized prognosis prediction, demonstrating superior predictive performance compared to the conventional BCLC staging system. CONCLUSION: The NIIS and nomogram provide a clinically useful tool for risk stratification in HCC immunotherapy, this model outperforming conventional staging systems and may optimize patient selection for PD-1 inhibitor therapy. Prospective multicenter studies are warranted to validate its generalizability. CI - (c) 2025 Liu et al. FAU - Liu, Kan AU - Liu K AUID- ORCID: 0009-0001-6513-6000 AD - Department of Oncology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, People's Republic of China. FAU - Lv, Yaqin AU - Lv Y AD - The Wuxi Branch of the 904th Hospital of the Joint Logistic Support Force, Wuxi, Jiangsu Province, People's Republic of China. FAU - Fu, Shumin AU - Fu S AD - Department of Oncology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, People's Republic of China. FAU - Mao, Ye AU - Mao Y AD - Department of Oncology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, People's Republic of China. FAU - Xu, Yongkang AU - Xu Y AUID- ORCID: 0000-0003-4500-6580 AD - Department of Oncology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, People's Republic of China. FAU - Huang, Shenglan AU - Huang S AD - Department of Oncology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, People's Republic of China. FAU - Wu, Jianbing AU - Wu J AD - Department of Oncology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, People's Republic of China. LA - eng PT - Journal Article DEP - 20250927 PL - New Zealand TA - J Inflamm Res JT - Journal of inflammation research JID - 101512684 PMC - PMC12489024 OTO - NOTNLM OT - PD-1 inhibitors OT - hepatocellular carcinoma OT - nutritional-immuno-inflammatory indicators OT - prognostic model OT - survival prediction COIS- The authors report no potential conflicts of interest in this work. EDAT- 2025/10/06 12:31 MHDA- 2025/10/06 12:32 PMCR- 2025/09/27 CRDT- 2025/10/06 07:17 PHST- 2025/06/11 00:00 [received] PHST- 2025/09/11 00:00 [accepted] PHST- 2025/10/06 12:32 [medline] PHST- 2025/10/06 12:31 [pubmed] PHST- 2025/10/06 07:17 [entrez] PHST- 2025/09/27 00:00 [pmc-release] AID - 546164 [pii] AID - 10.2147/JIR.S546164 [doi] PST - epublish SO - J Inflamm Res. 2025 Sep 27;18:13397-13412. doi: 10.2147/JIR.S546164. eCollection 2025. PMID- 41048279 OWN - NLM STAT- MEDLINE DCOM- 20251006 LR - 20251114 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Study protocol: post-harvest losses of fruits and vegetables and their relationship with the nutritional status of women and children. PG - 1654786 LID - 10.3389/fpubh.2025.1654786 [doi] LID - 1654786 AB - INTRODUCTION: Sub-Saharan Africa loses up to 50% of fruits and vegetables produced annually, with Ghana alone reporting post-harvest losses ranging between 30 and 50% across the value chain. These losses significantly threaten nutrition security by reducing the availability of essential nutrients in the food system. Capturing these lost nutrients is crucial to promoting healthy and affordable diets. This study protocol presents a community-based randomised controlled trial (RCT) being implemented in the Ho West District of Ghana. The trial aims to investigate the association between post-harvest loss (PHL) of fruits and vegetables and the nutritional status of women and children, while also identifying loss drivers across the value chain. METHODS: This experimental trial study employs an untreated control group design and involves 280 participants, comprising 70 farmers, 70 traders, and 140 women and their children. Socio-demographic data and post-harvest practices will be collected from all participants to estimate nutritional losses. Dietary intake of fruits and vegetables will be assessed using food frequency questionnaires, while food consumption and household hunger will be measured using validated scoring tools. Anthropometric and nutritional measurements will be recorded for women and children using WHO protocols. Women in the intervention arm will receive nutrition education and counselling focused on storage and preservation strategies to reduce food waste. POTENTIAL IMPACT: This study will provide evidence on the link between post-harvest loss and nutritional outcomes and inform practical interventions for reducing PHL at the community level. It offers a platform for building capacity among farmers, traders, and caregivers through increased awareness and behaviour change. By integrating nutrition education into PHL mitigation, the findings have the potential to influence food systems policy, improve household nutrition, and contribute to global efforts to reduce food loss. The trial is currently ongoing, and this protocol outlines the study's design, methodology, and implementation framework. CLINICAL TRIAL REGISTRATION: This trial is registered with the Pan African Clinical Trial Registry (PACTR202310582275172). CI - Copyright (c) 2025 Twum-Dei, Lutterodt, Annan and Aduku. FAU - Twum-Dei, Benedicta AU - Twum-Dei B AD - Department of Biochemistry and Biotechnology, College of Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. AD - School of Nursing and Midwifery, Heritage Christian University College, Accra, Ghana. FAU - Lutterodt, Herman Erick AU - Lutterodt HE AD - Department of Food Science and Technology, College of Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. FAU - Annan, Reginald Adjetey AU - Annan RA AD - Department of Biochemistry and Biotechnology, College of Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. FAU - Aduku, Linda Nana Esi AU - Aduku LNE AD - Department of Biochemistry and Biotechnology, College of Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20250918 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Adult MH - Child MH - Female MH - Humans MH - Male MH - Middle Aged MH - *Food Supply/statistics & numerical data MH - *Fruit/supply & distribution MH - Ghana MH - *Nutritional Status MH - *Vegetables MH - Randomized Controlled Trials as Topic PMC - PMC12490541 OTO - NOTNLM OT - children OT - fruits and vegetables OT - nutritional status OT - post-harvest loss OT - women COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/10/06 12:31 MHDA- 2025/10/06 12:32 PMCR- 2025/09/18 CRDT- 2025/10/06 07:04 PHST- 2025/06/26 00:00 [received] PHST- 2025/08/20 00:00 [accepted] PHST- 2025/10/06 12:32 [medline] PHST- 2025/10/06 12:31 [pubmed] PHST- 2025/10/06 07:04 [entrez] PHST- 2025/09/18 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1654786 [doi] PST - epublish SO - Front Public Health. 2025 Sep 18;13:1654786. doi: 10.3389/fpubh.2025.1654786. eCollection 2025. PMID- 41048258 OWN - NLM STAT- MEDLINE DCOM- 20251006 LR - 20251008 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Exploring self-rated health, physical activity, and social anxiety among female Chinese university students: a variable- and person-centered analysis. PG - 1681504 LID - 10.3389/fpubh.2025.1681504 [doi] LID - 1681504 AB - BACKGROUND: Physical inactivity is a significant public health issue among female college students. This study aimed to explore the complex relationship between self-rated health (SRH), social anxiety (SA), and physical activity (PA) in a sample of female Chinese university students, employing both variable-centered and person-centered approaches. METHODS: A cross-sectional survey was conducted with a sample of 1,452 female Chinese university students who completed the Self-Perceived Health Scale (to measure SRH), the Social Interaction Anxiety Scale-6 and the Social Phobia Scale-6 (to measure SA), and a validated single-item measure of PA (to measure PA). First, a mediation model was used to test the indirect effect of SRH on PA through SA. Second, Latent Profile Analysis was conducted to identify distinct subgroups based on individuals' SRH and SA levels. Finally, ANOVA was used to examine PA differences across the identified profiles. RESULTS: The mediation analysis revealed that SA partially mediated the relationship between SRH and PA, accounting for 12% of the total effect (CI [0.011, 0.090]). The Latent Profile Analysis identified three distinct profiles: "Healthy-Resilient" (21.62%), characterized by high SRH and low SA; "Moderate-Adapting" (70.39%), with average SRH and SA; and "Unhealthy-Anxious" (7.99%), with low SRH and high SA. The "Unhealthy-Anxious" group reported significantly lower levels of PA than the other two groups. CONCLUSION: Our findings suggest that SA is a significant psychological mechanism linking SRH to PA among female Chinese university students. From a public health perspective, these findings highlight the importance of addressing mental health factors, such as SA, in interventions designed to promote PA in this population. The identification of distinct subgroups underscores the need for tailored interventions over one-size-fits-all approaches. CI - Copyright (c) 2025 Huang, Chen and Hu. FAU - Huang, Wenying AU - Huang W AD - Physical Education College, Jiangxi Normal University, Nanchang, China. FAU - Chen, Bin AU - Chen B AD - Physical Education College, Jiangxi Normal University, Nanchang, China. FAU - Hu, Chang AU - Hu C AD - Physical Education College, Jiangxi Normal University, Nanchang, China. LA - eng PT - Journal Article DEP - 20250918 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Female MH - *Students/psychology/statistics & numerical data MH - Universities MH - *Exercise/psychology MH - Cross-Sectional Studies MH - China MH - Young Adult MH - *Anxiety/epidemiology/psychology MH - Adult MH - Surveys and Questionnaires MH - *Health Status MH - Adolescent MH - Self Report PMC - PMC12488654 OTO - NOTNLM OT - female college students OT - latent profile analysis OT - mediation analysis OT - physical activity OT - self-rated health OT - social anxiety COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/10/06 12:30 MHDA- 2025/10/06 12:31 PMCR- 2025/09/18 CRDT- 2025/10/06 07:04 PHST- 2025/08/07 00:00 [received] PHST- 2025/09/03 00:00 [accepted] PHST- 2025/10/06 12:31 [medline] PHST- 2025/10/06 12:30 [pubmed] PHST- 2025/10/06 07:04 [entrez] PHST- 2025/09/18 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1681504 [doi] PST - epublish SO - Front Public Health. 2025 Sep 18;13:1681504. doi: 10.3389/fpubh.2025.1681504. eCollection 2025. PMID- 41047439 OWN - NLM STAT- MEDLINE DCOM- 20251105 LR - 20260915 IS - 1573-3521 (Electronic) IS - 0160-7715 (Print) IS - 0160-7715 (Linking) VI - 48 IP - 6 DP - 2025 Dec TI - Using objective measures to evaluate the role of physical activity as a compensatory mechanism of emotion regulation. PG - 918-928 LID - 10.1007/s10865-025-00606-6 [doi] AB - Both emotion regulation and physical activity are associated with improved emotional well-being, including high self-esteem. However, most prior work comparing this relationship is limited by either subjective bias or ecological validity. Using objective (i.e., accelerometer-derived) measures of physical activity, this study investigated the relationship between moderate-to-vigorous physical activity (MVPA) and two trait emotion regulation strategies. We predicted that trait reappraisal (i.e., the habitual use of cognitive reappraisal to regulate emotions in daily life), but not trait suppression (i.e., the habitual use of expressive suppression to regulate emotions in daily life), would be associated with higher engagement in MVPA. We also predicted that physical activity would buffer reliance on trait reappraisal, such that individuals who engaged in more MVPA would be less likely to report emotion regulation difficulties or low self-esteem. Participants (N = 251 adults, ages 17-88 years) filled out questionnaires assessing trait emotion regulation, emotion regulation difficulties, and self-esteem, and wore an ActiGraph(R) on their non-dominant wrist for one week (M(SD) = 7.46(2.32) days). Regression and moderation analyses were conducted on variables of interest. Neither trait reappraisal nor suppression were associated with MVPA. MVPA significantly moderated the negative relationship between trait reappraisal and emotion regulation difficulties, such that the relationship was stronger at lower levels of MVPA. Effects were not found with self-esteem or trait suppression. These results indicate that MVPA may be beneficial in maintaining emotional well-being, particularly in the face of emotion regulation difficulties. CI - (c) 2025. The Author(s). FAU - Kupka, Grace AU - Kupka G AUID- ORCID: 0009-0004-3956-3019 AD - Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA. AD - Center for Brain, Biology, and Behavior, University of Nebraska-Lincoln, B84 East Stadium, Lincoln, NE, 68588-0156, USA. AD - Sleep Research Laboratory, E.P. Bradley Hospital, Providence, RI, USA. FAU - Humphries, Ashley AU - Humphries A AUID- ORCID: 0009-0002-9358-1280 AD - Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA. AD - Center for Brain, Biology, and Behavior, University of Nebraska-Lincoln, B84 East Stadium, Lincoln, NE, 68588-0156, USA. FAU - Goldberg, Emily AU - Goldberg E AD - Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA. AD - Center for Brain, Biology, and Behavior, University of Nebraska-Lincoln, B84 East Stadium, Lincoln, NE, 68588-0156, USA. FAU - Harp, Nicholas AU - Harp N AUID- ORCID: 0000-0002-8115-9309 AD - Department of Psychology, University of California at Berkeley, Berkeley, CA, USA. FAU - Nelson, Timothy AU - Nelson T AD - Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA. AD - Center for Brain, Biology, and Behavior, University of Nebraska-Lincoln, B84 East Stadium, Lincoln, NE, 68588-0156, USA. FAU - Neta, Maital AU - Neta M AUID- ORCID: 0000-0001-8586-0963 AD - Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA. mneta2@unl.edu. AD - Center for Brain, Biology, and Behavior, University of Nebraska-Lincoln, B84 East Stadium, Lincoln, NE, 68588-0156, USA. mneta2@unl.edu. LA - eng GR - R01 MH111640/MH/NIMH NIH HHS/United States GR - R01MH111640/MH/NIMH NIH HHS/United States GR - Nebraska Tobacco Settlement Biomedical Research Development Fund/Nebraska Tobacco Settlement Biomedical Research Development Fund/ GR - CAREER Award 1752848/National Science Foundation/ PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Research Support, U.S. Gov't, P.H.S. DEP - 20251005 PL - United States TA - J Behav Med JT - Journal of behavioral medicine JID - 7807105 SB - IM MH - Humans MH - Female MH - *Emotional Regulation/physiology MH - Male MH - Adult MH - Middle Aged MH - *Exercise/psychology/physiology MH - Aged MH - Adolescent MH - Young Adult MH - *Self Concept MH - Aged, 80 and over MH - Accelerometry MH - *Emotions/physiology MH - Surveys and Questionnaires PMC - PMC12589386 OTO - NOTNLM OT - Actigraphy OT - Cognitive reappraisal OT - Emotion regulation OT - Physical activity OT - Self-esteem COIS- Declarations. Conflict of interest: The authors declare that they have no conflict of interest. Consent to participate: All participants aged 19 and up (the age of majority in the state in which the research was conducted) provided written consent and were compensated for their time. Participants aged 17 and 18 provided written assent and parental consent, or a written waiver of parental consent. Consent for publication: Participants signed informed consent regarding publishing their data. Ethical approval: The protocols in this study were approved by University of Nebraska-Lincoln's Institutional Review Board (Approval #20150314841EP, # 20141114675, and # 20150114800EP) and in accordance with the Declaration of Helsinki. EDAT- 2025/10/06 00:27 MHDA- 2025/11/06 00:27 PMCR- 2025/10/05 CRDT- 2025/10/05 23:17 PHST- 2024/10/15 00:00 [received] PHST- 2025/09/06 00:00 [accepted] PHST- 2025/11/06 00:27 [medline] PHST- 2025/10/06 00:27 [pubmed] PHST- 2025/10/05 23:17 [entrez] PHST- 2025/10/05 00:00 [pmc-release] AID - 10.1007/s10865-025-00606-6 [pii] AID - 606 [pii] AID - 10.1007/s10865-025-00606-6 [doi] PST - ppublish SO - J Behav Med. 2025 Dec;48(6):918-928. doi: 10.1007/s10865-025-00606-6. Epub 2025 Oct 5. PMID- 41047276 OWN - NLM STAT- MEDLINE DCOM- 20251005 LR - 20251028 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 10 DP - 2025 Oct 5 TI - Bridging the gap: development of a methodology for retrieving and harmonising body mass index (BMI) from population-level linked electronic health records. PG - e103724 LID - 10.1136/bmjopen-2025-103724 [doi] LID - e103724 AB - OBJECTIVE: This study aims to develop a methodology to retrieve, harmonise and evaluate the completeness of national body mass index (BMI) data from linked electronic health record (EHR) sources to build a longitudinal research-ready data asset (RRDA). DESIGN: A longitudinal study of BMI records spanning 23 years (1 January 2000 to 31 December 2022) from four data sources. SETTING: The national BMI RRDA is created within the Secure Anonymised Information Linkage (Databank), encompassing the entire population of Wales, UK. PROCEDURE AND PARTICIPANTS: We built a methodology that provides a reproducible framework for extracting and harmonising BMI data from four major linked EHRs across two age groups: children and young people (CYP; 2-18 years old) and adults (19 years and older). The methodology is adaptable across different trusted research environments. We evaluated the completeness and retention of records over 1-, 5- and 23-year periods by calculating the proportion of missing data relative to each year's population. RESULTS: We retrieved 53.4 million records for 3.2 million individuals across Wales from 1st January 2000 to 31 December 2022. Among these, 3% of CYP and 34% of adults had repeat BMI measurements recorded over periods ranging from 5 to 23 years. Throughout the entire population of Wales during this period, 49% of CYP and 26% of adults had at least one BMI reading recorded, resulting in a missingness rate of 51% for CYP and 74% for adults. Preserving BMI information by retaining the most recently recorded BMI over 1-, 5- and 23-year intervals from 2022 showed coverage rates of 10%, 33% and 68%, respectively, for CYP, and 25%, 51% and 73%, respectively, for adults. CONCLUSIONS: Our findings highlight substantial variations in BMI data availability and retention across CYP and adults, as well as time periods within EHR in Wales. Wider adoption of this approach can enhance standardised approaches in using accessible measures like BMI to assess disease risk in population-based studies, strengthening public health initiatives and research efforts. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY. Published by BMJ Group. FAU - Childs, Michael Jeanne AU - Childs MJ AUID- ORCID: 0000-0001-9086-8898 AD - Population Data Science, Swansea University Medical School, Swansea, UK. FAU - Aldridge, Sarah J AU - Aldridge SJ AD - Population Data Science, Swansea University Medical School, Swansea, UK. FAU - Daniels, Helen AU - Daniels H AD - Population Data Science, Swansea University Medical School, Swansea, UK. FAU - Davies, Gareth Ivor AU - Davies GI AD - Population Data Science, Swansea University Medical School, Swansea, UK. FAU - Best, Victoria AU - Best V AD - Population Data Science, Swansea University Medical School, Swansea, UK. FAU - Abbasizanjani, Hoda AU - Abbasizanjani H AUID- ORCID: 0000-0002-9575-4758 AD - Population Data Science, Swansea University Medical School, Swansea, UK. FAU - Lyons, Ronan AU - Lyons R AUID- ORCID: 0000-0001-5225-000X AD - Population Data Science, Swansea University Medical School, Swansea, UK. FAU - Akbari, Ashley AU - Akbari A AUID- ORCID: 0000-0003-0814-0801 AD - Population Data Science, Swansea University Medical School, Swansea, UK. FAU - Torabi, Fatemeh AU - Torabi F AUID- ORCID: 0000-0002-5853-4625 AD - Population Data Science, Swansea University Medical School, Swansea, UK Fatemeh.Torabi@Swansea.ac.uk. AD - Dementias Platform UK, Swansea, UK. AD - Professional and Continuing Education, University of Cambridge, Cambridge, UK. LA - eng GR - WT_/Wellcome Trust/United Kingdom PT - Journal Article DEP - 20251005 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Body Mass Index MH - *Electronic Health Records/statistics & numerical data MH - Adolescent MH - Child MH - Wales/epidemiology MH - Adult MH - Young Adult MH - Child, Preschool MH - Longitudinal Studies MH - Male MH - Female MH - Middle Aged MH - *Information Storage and Retrieval/methods MH - *Medical Record Linkage/methods MH - Aged PMC - PMC12506101 OTO - NOTNLM OT - Body Mass Index OT - EPIDEMIOLOGY OT - Electronic Health Records OT - PUBLIC HEALTH COIS- Competing interests: RL was an unpaid member of the COVID-19 Welsh Government Technical Advisory Group and receives funding from MRC and ESRC. FT receives funding from MRC - Integrated Dementia Experimental Medicine. All other authors have no competing interest to declare. EDAT- 2025/10/06 00:27 MHDA- 2025/10/06 00:28 PMCR- 2025/10/05 CRDT- 2025/10/05 21:23 PHST- 2025/10/06 00:28 [medline] PHST- 2025/10/06 00:27 [pubmed] PHST- 2025/10/05 21:23 [entrez] PHST- 2025/10/05 00:00 [pmc-release] AID - bmjopen-2025-103724 [pii] AID - 10.1136/bmjopen-2025-103724 [doi] PST - epublish SO - BMJ Open. 2025 Oct 5;15(10):e103724. doi: 10.1136/bmjopen-2025-103724. PMID- 41045803 OWN - NLM STAT- MEDLINE DCOM- 20251203 LR - 20251203 IS - 1874-9968 (Electronic) IS - 0041-624X (Linking) VI - 159 DP - 2026 Mar TI - Cortical bone parameters measured at the one-third distal radius obtained with axial transmission and HR-pQCT compared with anthropometric data in a representative population. PG - 107829 LID - S0041-624X(25)00266-5 [pii] LID - 10.1016/j.ultras.2025.107829 [doi] AB - Fragility fractures remain an important health issue, in the context of aging populations. Ultrasonic measurement of cortical bone thickness (Ct.Th) and porosity (Ct.Po) at peripheral sites (forearm or leg) has been shown to be predictive of non-vertebral fragility fractures, with performance comparable with X-ray gold standard (DXA). Ultrasonic parameters (Ct.Th and Ct.Po) were measured using a Bi-Directional Axial Transmission (BDAT) device at the one-third distal radius. These values were validated, compared with site matched measurement of Ct.Th and volumetric Bone Mineral Density (Ct.vBMD) obtained with High Resolution peripheral Computed Tomography (HR-pQCT). Sixty-six participants (41 women, 25 men), aged 18 to 87 years old, with Body Mass Index (BMI) ranging from 16 to 30 kg.m(-2), were included. Significant linear correlations (p<0.01) were observed considering regular measurements: Ct.Th decreases with age and increases with Body Surface Area (BSA), height and weight. Opposite variations were observed for Ct.Po. Irregular measurements were associated with significantly older participants (71+/-10vs49+/-17 y.o.) and with thinner (2.3+/-0.5vs3.2+/-0.6mm) and more porous (10.9+/-3.5vs8.6+/-3.3 %) cortical bone with respect to regular measurements (p<0.002), while no significant differences were observed for other anthropometric data. It suggests that measurement irregularities can be associated with the trabecularization process. The integration of these reference values, with respect to anthropometric data (height, weight, BSA), should improve the detection of people at risk of fragility fractures using ultrasonic devices. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Minonzio, Jean-Gabriel AU - Minonzio JG AD - Escuela de Ingenieria Civil en Informatica, Universidad de Valparaiso, Center of Interdisciplinary Biomedical and Engineering Research for Health - MEDING, Universidad de Valparaiso, General Cruz 222, Valparaiso, Chile; Interuniversity Network for Healthy Aging, Latin America and the Caribbean (RIES-LAC). Electronic address: jean-gabriel.minonzio@uv.cl. FAU - Ramiandrisoa, Donatien AU - Ramiandrisoa D AD - Myriade, Quattrocento, 30 Rue de Campo-Formio, 75013, Paris, 75013, France. FAU - Fernandez, Sylvie AU - Fernandez S AD - Department of rheumatology, Hopital Lariboisiere, BIOSCAR, Inserm U1132, Universite Paris Cite, Paris, France. FAU - Chappard, Christine AU - Chappard C AD - Laboratoire d'Imagerie Biomedicale (LIB), CNRS UMR 7371, INSERM U1146, Sorbonne Universite, Paris, France. FAU - Cohen-Solal, Martine AU - Cohen-Solal M AD - Department of rheumatology, Hopital Lariboisiere, BIOSCAR, Inserm U1132, Universite Paris Cite, Paris, France. LA - eng PT - Comparative Study PT - Journal Article DEP - 20250930 PL - Netherlands TA - Ultrasonics JT - Ultrasonics JID - 0050452 SB - IM MH - Humans MH - Female MH - Middle Aged MH - Aged MH - Male MH - Adult MH - *Radius/diagnostic imaging MH - Aged, 80 and over MH - Young Adult MH - *Cortical Bone/diagnostic imaging MH - Adolescent MH - Bone Density MH - *Tomography, X-Ray Computed/methods MH - Ultrasonography/methods MH - Anthropometry OTO - NOTNLM OT - Axial transmission OT - Cortical bone OT - Cortical porosity OT - Cortical thickness OT - Ultrasonic guided waves COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Jean-Gabriel Minonzio has patent #WO2010142927A1 issued to CNRS. Jean-Gabriel Minonzio has patent #WO2015010878A1 issued to Azalee, CNRS, UPMC. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/10/05 00:34 MHDA- 2025/12/04 02:11 CRDT- 2025/10/04 18:08 PHST- 2025/06/04 00:00 [received] PHST- 2025/08/23 00:00 [revised] PHST- 2025/09/22 00:00 [accepted] PHST- 2025/12/04 02:11 [medline] PHST- 2025/10/05 00:34 [pubmed] PHST- 2025/10/04 18:08 [entrez] AID - S0041-624X(25)00266-5 [pii] AID - 10.1016/j.ultras.2025.107829 [doi] PST - ppublish SO - Ultrasonics. 2026 Mar;159:107829. doi: 10.1016/j.ultras.2025.107829. Epub 2025 Sep 30. PMID- 41044845 OWN - NLM STAT- MEDLINE DCOM- 20260327 LR - 20260813 IS - 1461-7277 (Electronic) IS - 1359-1053 (Print) IS - 1359-1053 (Linking) VI - 31 IP - 5 DP - 2026 Apr TI - Reasons for exercise inventory: A validation of the Dutch version in a community sample and a sample of women with an eating disorder. PG - 1815-1826 LID - 10.1177/13591053251375314 [doi] AB - The reasons for exercise inventory (REI) is a self-report instrument to assess why people exercise. It is important to assess the reasons for exercise in people with an eating disorder (ED), who regularly suffer from compulsive exercise. In this study the psychometric properties of the Dutch version of the REI and differences in scores are evaluated in an ED and a community sample consisting of women. Factor analysis revealed three factors: health, appearance/weight and mood. Reliability (internal consistency, test-retest) was good. The ED sample scored significantly lower on the Health subscale and significantly higher on the appereance/weight and mood subscales than the community sample exercising for appearance/weight showed a moderately positive correlation with EDE-Q scores in both samples. The Dutch version of the REI showed promising psychometric properties that support its value for clinical and research purposes. Using three subscales may enhance research and assessment of the reasons for exercise. FAU - Nieuwenhuijse, Aurelie AU - Nieuwenhuijse A AUID- ORCID: 0009-0000-8444-5557 AD - Utrecht University, the Netherlands. AD - Windesheim University of Applied Sciences, Zwolle, the Netherlands. AD - Emergis Network EEN, Goes, the Netherlands. FAU - Scheffers, Mia AU - Scheffers M AUID- ORCID: 0000-0003-0469-1569 AD - Windesheim University of Applied Sciences, Zwolle, the Netherlands. FAU - Rekkers, Marlies AU - Rekkers M AUID- ORCID: 0000-0001-8139-4336 AD - Windesheim University of Applied Sciences, Zwolle, the Netherlands. FAU - van Busschbach, Jooske T AU - van Busschbach JT AD - Windesheim University of Applied Sciences, Zwolle, the Netherlands. AD - University of Groningen, University Medical Center Groningen, Rob Giel Onderzoekcentrum, the Netherlands. FAU - van Elburg, Annemarie A AU - van Elburg AA AD - Utrecht University, the Netherlands. LA - eng PT - Journal Article PT - Validation Study DEP - 20251003 PL - England TA - J Health Psychol JT - Journal of health psychology JID - 9703616 SB - IM MH - Humans MH - Female MH - *Exercise/psychology MH - *Feeding and Eating Disorders/psychology MH - Adult MH - Psychometrics MH - Netherlands MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - Middle Aged MH - Young Adult MH - Adolescent MH - Factor Analysis, Statistical PMC - PMC13031372 OTO - NOTNLM OT - body satisfaction OT - compulsive exercise OT - eating disorders OT - psychometric evaluation OT - reasons for exercise COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/10/04 06:32 MHDA- 2026/03/27 17:38 PMCR- 2026/03/28 CRDT- 2025/10/04 00:52 PHST- 2026/03/27 17:38 [medline] PHST- 2025/10/04 06:32 [pubmed] PHST- 2025/10/04 00:52 [entrez] PHST- 2026/03/28 00:00 [pmc-release] AID - 10.1177_13591053251375314 [pii] AID - 10.1177/13591053251375314 [doi] PST - ppublish SO - J Health Psychol. 2026 Apr;31(5):1815-1826. doi: 10.1177/13591053251375314. Epub 2025 Oct 3. PMID- 41044474 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 25 IP - 1 DP - 2025 Oct 3 TI - Validity of mid-upper arm circumference in assessing thinness among older children aged 5-9 years: a cross-sectional study. PG - 762 LID - 10.1186/s12887-025-06120-7 [doi] LID - 762 AB - BACKGROUND: With the high burden of malnutrition, accurate yet convenient anthropometric measurements are vital. Although body mass index (BMI) for age and sex z score (BAZ) is the recommended assessment method for children aged 5-9 years, it is quite cumbersome. Uganda adopted use of the convenient mid-upper arm circumference (MUAC) for these children. However, the basis for MUAC use in this age-group is weak, requiring more evidence generation. We therefore determined validity of MUAC in assessing thinness among children aged 5-9 years. METHODS: This was a cross-sectional study. Demographic and anthropometric data was taken from children aged 5-9 years who attended 3 health facilities in Kampala district. MUAC was measured using colour-coded MUAC tapes for children aged 5-9 years and compared with the BAZ. We used a MUAC cut-off of 145 mm for wasting and below 140 mm for severe wasting as per the national guidelines. The sensitivity, specificity, negative and positive predictive values of MUAC were determined using BAZ as the gold standard. Receiver Operating Characteristic curves were plotted to determine the validity of MUAC. RESULTS: Of the 767 children, 51.5% were female and the mean age was 7.2 +/-1.6 years. According to MUAC, 1% had severe acute malnutrition (SAM), 2.7% moderate acute malnutrition (MAM) and 96.2% had no acute malnutrition. The sensitivity and specificity of MUAC in assessment of acute malnutrition (SAM and MAM) were 22.7%, 95% CI (11.5-37.8) and 97.3%, 95% CI (95.9-98.4) respectively. The positive and negative predictive values were 34.5%, 95% CI (17.9-54.3) and 95.4%, 95% CI (93.6-96.8) respectively. The area under the ROC curve was 0.30, 95%CI (0.206-0.394), indicating MUAC was a poor assessment tool for thinness, even after stratifying for age and Human Immune-deficiency Virus status. CONCLUSION: Despite MUAC being convenient, it showed a low diagnostic performance in assessing thinness among children 5-9 years. This reiterates the need for more research on the correct MUAC cut-offs for this age-group. FAU - Namirembe, Terry AU - Namirembe T AD - Department of Paediatrics and Child Health, Makerere University College of Health Sciences, P.O. Box 7072, Kampala, Uganda. FAU - Mupere, Ezekiel AU - Mupere E AD - Department of Paediatrics and Child Health, Makerere University College of Health Sciences, P.O. Box 7072, Kampala, Uganda. FAU - Namubiru, Teddy AU - Namubiru T AD - Department of Paediatrics and Child Health, Makerere University College of Health Sciences, P.O. Box 7072, Kampala, Uganda. FAU - Elyanu, Peter James AU - Elyanu PJ AD - Baylor College of Medicine Foundation-Uganda, Kampala, Uganda. FAU - Nabukeera-Barungi, Nicolette AU - Nabukeera-Barungi N AD - Department of Paediatrics and Child Health, Makerere University College of Health Sciences, P.O. Box 7072, Kampala, Uganda. nicolettebarungi@gmail.com. AD - Baylor College of Medicine Foundation-Uganda, Kampala, Uganda. nicolettebarungi@gmail.com. LA - eng PT - Journal Article PT - Validation Study DEP - 20251003 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Arm/anatomy & histology MH - Child, Preschool MH - Male MH - Female MH - *Thinness/diagnosis MH - Child MH - *Anthropometry/methods MH - Sensitivity and Specificity MH - Reproducibility of Results MH - ROC Curve MH - Uganda MH - Predictive Value of Tests MH - Body Mass Index PMC - PMC12495605 OTO - NOTNLM OT - Body mass index OT - Mid-upper arm circumference OT - Older children OT - Thinness OT - Validity COIS- Declarations. Ethics approval and consent to participate: All study procedures followed the Helsinki Declaration. Institutional approval was obtained from Makerere School of Medicine Research and Ethics Committee (SOMREC) and administrative clearance from the three health facilities involved in the study. Written informed consent was sought from the parents or immediate caregivers of the children and assent for those children aged 8 to 9 years. All information collected was treated with confidentiality. Children who were found with SAM were referred for treatment. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/10/04 00:30 MHDA- 2026/06/27 00:49 PMCR- 2025/10/03 CRDT- 2025/10/03 23:51 PHST- 2025/03/08 00:00 [received] PHST- 2025/08/27 00:00 [accepted] PHST- 2026/06/27 00:49 [medline] PHST- 2025/10/04 00:30 [pubmed] PHST- 2025/10/03 23:51 [entrez] PHST- 2025/10/03 00:00 [pmc-release] AID - 10.1186/s12887-025-06120-7 [pii] AID - 6120 [pii] AID - 10.1186/s12887-025-06120-7 [doi] PST - epublish SO - BMC Pediatr. 2025 Oct 3;25(1):762. doi: 10.1186/s12887-025-06120-7. PMID- 41044236 OWN - NLM STAT- MEDLINE DCOM- 20260130 LR - 20260702 IS - 1476-5438 (Electronic) IS - 1018-4813 (Print) IS - 1018-4813 (Linking) VI - 34 IP - 2 DP - 2026 Feb TI - Evaluating DNA methylation episignatures as a first-tier diagnostic test in individuals with suspected genetic disorders. PG - 296-299 LID - 10.1038/s41431-025-01939-1 [doi] AB - DNA methylation (DNAm) episignature analysis is an emerging tool for diagnosing individuals with neurodevelopmental disorders, congenital anomalies, and growth disorders. We evaluated its clinical utility as a first-tier test in 62 individuals without prior molecular testing. DNAm arrays identified a diagnosis in 30.6% (19/62) of cases. The positivity rate was highest for Fragile X syndrome (100%, 5/5), followed by syndromic disorders (44%, 8/18) and imprinting disorders (25%, 6/24), including Silver-Russell, Beckwith-Wiedemann, and Prader-Willi syndromes. No diagnoses were made in 15 individuals with non-syndromic neurodevelopmental disorders. Alternative diagnoses were identified in 4.8% (3/62) of cases. These findings suggest that DNAm arrays can serve as an effective first-tier diagnostic tool, particularly for syndromic and imprinting disorders, with potential to improve diagnostic efficiency and reduce reliance on sequential genetic testing. While these findings support the use of DNAm arrays as an effective first-tier tool in selected populations, larger, unselected cohort studies are needed to validate its generalizability. CI - (c) 2025. The Author(s), under exclusive licence to European Society of Human Genetics. FAU - Tkemladze, Tinatin AU - Tkemladze T AUID- ORCID: 0000-0003-1924-6695 AD - Department of Molecular and Medical Genetics, Tbilisi State Medical University, Tbilisi, Georgia. t.tkemaladze@tsmu.edu. AD - Division of Clinical Genetics, Givi Zhvania Pediatric University Clinic, Tbilisi State Medical University, Tbilisi, Georgia. t.tkemaladze@tsmu.edu. FAU - Campbell, Christopher AU - Campbell C AD - Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester, UK. FAU - Bregvadze, Kakha AU - Bregvadze K AD - Department of Molecular and Medical Genetics, Tbilisi State Medical University, Tbilisi, Georgia. FAU - Kvaratskhelia, Eka AU - Kvaratskhelia E AD - Department of Molecular and Medical Genetics, Tbilisi State Medical University, Tbilisi, Georgia. FAU - Abzianidze, Elene AU - Abzianidze E AD - Department of Molecular and Medical Genetics, Tbilisi State Medical University, Tbilisi, Georgia. FAU - Demain, Leigh AU - Demain L AD - Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester, UK. FAU - Jenkinson, Sarah AU - Jenkinson S AD - Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester, UK. FAU - Hilton, Sarah AU - Hilton S AD - Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester, UK. FAU - Levy, Michael AU - Levy M AD - Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada. AD - Verspeeten Clinical Genome Centre, London Health Sciences Centre, London, ON, Canada. FAU - Kerkhof, Jennifer AU - Kerkhof J AUID- ORCID: 0000-0003-1245-6606 AD - Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada. AD - Verspeeten Clinical Genome Centre, London Health Sciences Centre, London, ON, Canada. FAU - Gokhale, David AU - Gokhale D AD - Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester, UK. FAU - Sadikovic, Bekim AU - Sadikovic B AUID- ORCID: 0000-0001-6363-0016 AD - Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada. AD - Verspeeten Clinical Genome Centre, London Health Sciences Centre, London, ON, Canada. FAU - Banka, Siddharth AU - Banka S AD - Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester, UK. AD - Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. LA - eng PT - Journal Article DEP - 20251003 PL - England TA - Eur J Hum Genet JT - European journal of human genetics : EJHG JID - 9302235 SB - IM CIN - Eur J Hum Genet. 2026 Feb;34(2):169-170. doi: 10.1038/s41431-025-01969-9. PMID: 41139747 MH - Humans MH - *DNA Methylation MH - *Genetic Testing/methods/standards MH - Male MH - Female MH - Fragile X Syndrome/diagnosis/genetics MH - Child MH - Prader-Willi Syndrome/diagnosis/genetics MH - Child, Preschool MH - Adolescent MH - *Genetic Diseases, Inborn/diagnosis/genetics MH - Genomic Imprinting MH - Infant MH - Adult PMC - PMC12858995 COIS- Competing interests: B.S. is a shareholder in EpiSign Inc. Ethical approval: The study was approved by local Institutional Review Board. Written and oral consent from all individuals' legal representatives was obtained. Consent was obtained to publish identifying photos. EDAT- 2025/10/04 00:30 MHDA- 2026/01/31 00:29 PMCR- 2027/02/01 CRDT- 2025/10/03 23:36 PHST- 2025/03/08 00:00 [received] PHST- 2025/09/01 00:00 [accepted] PHST- 2025/06/25 00:00 [revised] PHST- 2026/01/31 00:29 [medline] PHST- 2025/10/04 00:30 [pubmed] PHST- 2025/10/03 23:36 [entrez] PHST- 2027/02/01 00:00 [pmc-release] AID - 10.1038/s41431-025-01939-1 [pii] AID - 1939 [pii] AID - 10.1038/s41431-025-01939-1 [doi] PST - ppublish SO - Eur J Hum Genet. 2026 Feb;34(2):296-299. doi: 10.1038/s41431-025-01939-1. Epub 2025 Oct 3. PMID- 41042344 OWN - NLM STAT- MEDLINE DCOM- 20260122 LR - 20261009 IS - 1432-2218 (Electronic) IS - 0930-2794 (Linking) VI - 40 IP - 1 DP - 2026 Jan TI - Incidence of de novo gastroesophageal reflux disease following sleeve gastrectomy versus sleeve gastrectomy with transit bipartition: a retrospective cohort study. PG - 118-125 LID - 10.1007/s00464-025-12276-1 [doi] AB - BACKGROUND: Sleeve gastrectomy (SG) is the most commonly performed bariatric procedure worldwide; however, concerns persist regarding the development of de novo gastroesophageal reflux disease (GERD) after surgery. Sleeve gastrectomy with transit bipartition (SG-TB) has emerged as a potential alternative, aiming to reduce GERD incidence while achieving superior weight loss outcomes. This study aimed to compare short-term outcomes of GERD, weight loss, and perioperative safety between SG and SG-TB. METHODS: A retrospective cohort study was conducted with 215 patients who underwent SG (n = 100) or SG-TB (n = 115) between January and December 2022. Eligible patients were aged 16-65 years with a body mass index (BMI) of >/= 27.5 kg/m(2) (with type 2 diabetes) or >/= 32.5 kg/m(2). GERD incidence was evaluated using the gastroesophageal reflux disease questionnaire (GERD-Q) and endoscopy 12 months after surgery. Weight loss was measured by percentage total weight loss (%TWL) and percentage excess weight loss (%EWL). Operative time, estimated blood loss, length of hospital stay, and 30-day postoperative complications were also compared. RESULTS: At 12 months, the SG-TB group demonstrated superior weight loss (%EWL: 112.0 +/- 38.2% vs. 97.2 +/- 25.5%, p = 0.001; %TWL: 33.8 +/- 7.4% vs. 31.1 +/- 6.4%, p = 0.006). The incidence of GERD was significantly lower in the SG-TB group (7.0% vs. 29.0%, p < 0.001). Multivariate regression analysis identified SG as an independent risk factor for developing de novo GERD postoperatively (OR 4.536, 95% CI 1.787-11.519, p = 0.001). SG-TB was associated with longer operative time but showed comparable early postoperative safety to SG. CONCLUSIONS: SG-TB significantly reduced the risk of postoperative GERD and resulted in superior short-term weight loss compared to SG, without increasing perioperative complication rates. Further multicenter, long-term studies are needed to validate these findings. CI - (c) 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Wang, Jian AU - Wang J AUID- ORCID: 0009-0006-6808-9365 AD - Department of Gastrointestinal Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, People's Republic of China. FAU - Ni, Liangchen AU - Ni L AD - Department of Gastrointestinal Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, People's Republic of China. FAU - Li, Tianci AU - Li T AD - Department of Gastrointestinal Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, People's Republic of China. FAU - Wang, Wanjie AU - Wang W AD - Department of Gastrointestinal Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, People's Republic of China. FAU - Song, Wenchao AU - Song W AD - Department of Gastrointestinal Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, People's Republic of China. FAU - Kitaghenda, Fidele Kakule AU - Kitaghenda FK AD - Department of Gastrointestinal Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, People's Republic of China. FAU - Hong, Jian AU - Hong J AD - Department of Gastrointestinal Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, People's Republic of China. AD - Department of Clinical Research Institute of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, People's Republic of China. FAU - Zhu, Xiaocheng AU - Zhu X AD - Department of Gastrointestinal Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, People's Republic of China. AD - Department of Clinical Research Institute of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, People's Republic of China. FAU - Yao, Libin AU - Yao L AD - Department of Gastrointestinal Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, People's Republic of China. yaolibin_123@126.com. AD - Department of Clinical Research Institute of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, People's Republic of China. yaolibin_123@126.com. LA - eng GR - KC22231/Xuzhou Municipal Science and Technology Bureau/ PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251003 PL - Germany TA - Surg Endosc JT - Surgical endoscopy JID - 8806653 SB - IM MH - Humans MH - *Gastroesophageal Reflux/epidemiology/etiology MH - Retrospective Studies MH - Female MH - Male MH - Adult MH - *Gastrectomy/methods/adverse effects MH - Middle Aged MH - Incidence MH - *Postoperative Complications/epidemiology/etiology MH - Weight Loss MH - Young Adult MH - *Obesity, Morbid/surgery MH - Adolescent MH - Aged MH - Operative Time MH - *Bariatric Surgery/methods/adverse effects OTO - NOTNLM OT - Bariatric surgery OT - Gastroesophageal reflux disease OT - Sleeve gastrectomy OT - Transit bipartition OT - Weight loss COIS- Declarations. Disclosures: Jian Wang, Liangchen Ni, Tianci Li, Wanjie Wang, Wenchao Song, Fidele Kakule Kitaghenda, Jian Hong, Xiaocheng Zhu and Libin Yao have no conflicts of interest or financial ties to disclose. Ethical approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent: Informed consent was obtained from all individual participants included in the study. EDAT- 2025/10/03 12:34 MHDA- 2026/01/22 07:43 CRDT- 2025/10/03 11:13 PHST- 2025/05/01 00:00 [received] PHST- 2025/09/23 00:00 [accepted] PHST- 2026/01/22 07:43 [medline] PHST- 2025/10/03 12:34 [pubmed] PHST- 2025/10/03 11:13 [entrez] AID - 10.1007/s00464-025-12276-1 [pii] AID - 10.1007/s00464-025-12276-1 [doi] PST - ppublish SO - Surg Endosc. 2026 Jan;40(1):118-125. doi: 10.1007/s00464-025-12276-1. Epub 2025 Oct 3. PMID- 41042325 OWN - NLM STAT- MEDLINE DCOM- 20251215 LR - 20260715 IS - 1432-0711 (Electronic) IS - 0932-0067 (Print) IS - 0932-0067 (Linking) VI - 312 IP - 6 DP - 2025 Dec TI - eHealth educational intervention: effects of an online video program in prevention of the pelvic women's health-a non-randomized experimental study. PG - 2153-2164 LID - 10.1007/s00404-025-08200-6 [doi] AB - PURPOSE: This study aimed to evaluate the effects of an online educational video program on pelvic floor health knowledge, sexual function, quality of life, and motivation for physical activity in women engaged in low- and high-intensity exercise. METHODS: A two-arm clinical trial was conducted with 60 women aged 18-35, divided into low- and high-intensity activity groups. Participants completed a six-week online video course covering pelvic floor anatomy, function, and self-management. Pre- and post-intervention assessments included validated questionnaires: PIKQ (pelvic floor knowledge), FSFI-19 (sexual function), BREQ-2 (exercise motivation), and EQOL-6D (quality of life). Data were analyzed using repeated measures ANOVA. RESULTS: Pelvic floor knowledge improved significantly in both groups (low-intensity: p < 0.001, d = 0.668; high-intensity: p < 0.001, d = 0.825), especially in POP-related knowledge (p < 0.001). Sexual function improved in desire (p = 0.046) and arousal (p = 0.027) for the low-intensity group, and in pain during intercourse for the high-intensity group (p = 0.049). No significant changes were found in exercise motivation (p > 0.05). Anxiety and depression scores improved only in the low-intensity group (p = 0.031). CONCLUSIONS: The online program effectively enhanced pelvic floor knowledge and aspects of sexual function, showing promise as a preventive educational tool for active women. TRIAL REGISTRATION: Registered in ClinicalTrials.gov (NCT05667012). Last update: 2024-12-06. CI - (c) 2025. The Author(s). FAU - Fuentes-Aparicio, Laura AU - Fuentes-Aparicio L AD - Physiotherapy in Motion, Multi Speciality Research Group (PTinMOTION), Department of Physiotherapy, University of Valencia, Carrer de Gasco Oliag, 5, 46010, Valencia, Spain. FAU - Dominguez-Navarro, Fernando AU - Dominguez-Navarro F AD - Department of Physiotherapy, Faculty of Physiotherapy, University of Valencia, Carrer de Gasco Oliag, 5, 46010, Valencia, Spain. Fernando.dominguez@uv.es. FAU - Maudos-Soriano, Ana AU - Maudos-Soriano A AD - Department of Physiotherapy, Faculty of Physiotherapy, University of Valencia, Carrer de Gasco Oliag, 5, 46010, Valencia, Spain. FAU - Hernandez-Guillen, David AU - Hernandez-Guillen D AD - Department of Physiotherapy, Faculty of Physiotherapy, University of Valencia, Carrer de Gasco Oliag, 5, 46010, Valencia, Spain. LA - eng SI - ClinicalTrials.gov/NCT05667012 PT - Clinical Trial PT - Journal Article DEP - 20251003 PL - Germany TA - Arch Gynecol Obstet JT - Archives of gynecology and obstetrics JID - 8710213 SB - IM MH - Humans MH - Female MH - Adult MH - Young Adult MH - Quality of Life MH - Adolescent MH - Exercise MH - Health Knowledge, Attitudes, Practice MH - Surveys and Questionnaires MH - Telemedicine MH - *Patient Education as Topic/methods MH - *Women's Health MH - Pelvic Floor MH - Video Recording MH - Motivation PMC - PMC12705780 OTO - NOTNLM OT - Education OT - Knowledge OT - Pelvic floor disorders OT - Women OT - eHealth COIS- Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: Approved by the Ethics Committee of Universitat de Valencia (code: 2432372, 12-1-2023). Consent to participate: Informed consent was obtained from all individual participants included in the study. EDAT- 2025/10/03 12:34 MHDA- 2025/12/15 13:10 PMCR- 2025/10/03 CRDT- 2025/10/03 11:12 PHST- 2025/07/08 00:00 [received] PHST- 2025/09/22 00:00 [accepted] PHST- 2025/12/15 13:10 [medline] PHST- 2025/10/03 12:34 [pubmed] PHST- 2025/10/03 11:12 [entrez] PHST- 2025/10/03 00:00 [pmc-release] AID - 10.1007/s00404-025-08200-6 [pii] AID - 8200 [pii] AID - 10.1007/s00404-025-08200-6 [doi] PST - ppublish SO - Arch Gynecol Obstet. 2025 Dec;312(6):2153-2164. doi: 10.1007/s00404-025-08200-6. Epub 2025 Oct 3. PMID- 41040857 OWN - NLM STAT- MEDLINE DCOM- 20260212 LR - 20260212 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 16 DP - 2025 TI - Prevalence of diabetes and prediabetes among working-age adults and influencing factors of new-onset diabetes: a five-year cohort study (2018-2023). PG - 1626925 LID - 10.3389/fendo.2025.1626925 [doi] LID - 1626925 AB - BACKGROUND: Diabetes and prediabetes in the young and middle-aged population represent a significant public health challenge in China. In recent years, the prevalence of diabetes has gradually increased within this group. This study aims to evaluate the prevalence of diabetes and prediabetes in a health check-up population of young and middle-aged individuals, and to analyze the key factors influencing the new onset of diabetes. The study provides data support for the early prevention of diabetes. METHOD: This study used retrospective cohort analyses to examine the data from the physical examination centers of three hospitals in Wuxi, China, for the population aged 18-59 from 2018 to 2023. Analyzing the changes in the prevalence of diabetes and prediabetes in the population. Single-factor analysis was used to examine differences in basic characteristics and laboratory indicators between individuals who developed diabetes and those who did not within five years. A multifactorial logistic regression model (MLR model), Cox proportional hazards model (Cox model), and generalized estimating equation (GEE) model were employed to analyze the factors associated with the development of diabetes. ROC curves were used to evaluate the performance of these three models. Finally, a nomogram was constructed to predict the risk of developing diabetes in the next five years. RESULTS: From 2018 to 2023, the number of diabetes cases increased year by year, with the highest increase of 1.39% observed between 2020 and 2021. New-onset diabetes patients had poorer lifestyle and health profiles compared to those without new-onset diabetes. New-onset diabetes group also had worse metabolic and inflammatory profiles (P < 0.05), with significantly lower eGFR (P = 0.027). The AUC values for all three models were 0.64, with the GEE model performing best in Youden index (0.237), the Cox model in sensitivity (0.577), and the MLR model in specificity (0.776). The most significant factors identified were NLR, FBG, Cr, BMI, and exercise habits. The nomogram built using these five factors showed good predictive performance with AUC values of 0.705 and 0.666 in the training and test sets, respectively. CONCLUSION: The significant factors influencing the onset of diabetes include NLR, FPG, Cr, BMI, and exercise habits. The nomogram can effectively predict the risk of diabetes in the next five years, providing a powerful tool for early intervention. Future research could explore the interactions among these factors and validate the model's applicability in different populations. CI - Copyright (c) 2025 Tan, Chen, Lei, Shi, Cao, Du, Yao and Yao. FAU - Tan, Jing AU - Tan J AD - Department of Endocrine, Wuxi People's Hospital, The Affiliated Wuxi People's Hospital of Nanjing Medical University and Wuxi Medical Center, Nanjing Medical University, Wuxi, China. FAU - Chen, Mingzhu AU - Chen M AD - Department of Endocrine, Wuxi People's Hospital, The Affiliated Wuxi People's Hospital of Nanjing Medical University and Wuxi Medical Center, Nanjing Medical University, Wuxi, China. FAU - Lei, Yang AU - Lei Y AD - Department of Clinical Nursing, School of Nursing Nanjing Medical University, Nanjing, China. FAU - Shi, Xiaofen AU - Shi X AD - Department of Internal Medicine Ward, Wuxi People's Hospital, The Affiliated Wuxi People's Hospital of Nanjing Medical University and Wuxi Medical Center Nanjing Medical University, Wuxi, China. FAU - Cao, Cuiping AU - Cao C AD - Department of Endocrine, Wuxi People's Hospital, The Affiliated Wuxi People's Hospital of Nanjing Medical University and Wuxi Medical Center, Nanjing Medical University, Wuxi, China. FAU - Du, Naili AU - Du N AD - Department of Endocrine, Wuxi People's Hospital, The Affiliated Wuxi People's Hospital of Nanjing Medical University and Wuxi Medical Center, Nanjing Medical University, Wuxi, China. FAU - Yao, Yuyou AU - Yao Y AD - Department of Health Management Center, Wuxi People's Hospital, The Affiliated Wuxi People's Hospital of Nanjing Medical University and Wuxi Medical Center, Nanjing Medical University, Wuxi, China. FAU - Yao, Xiaojuan AU - Yao X AD - Department of Emergency Medicine, Wuxi People's Hospital, The Affiliated Wuxi People's Hospital of Nanjing Medical University and Wuxi Medical Center, Nanjing Medical University, Wuxi, China. LA - eng PT - Journal Article DEP - 20250917 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Cohort Studies MH - Prevalence MH - *Prediabetic State/blood/epidemiology MH - Retrospective Studies MH - Age of Onset MH - Incidence MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged MH - China/epidemiology MH - Logistic Models MH - Proportional Hazards Models MH - Nomograms PMC - PMC12483861 OTO - NOTNLM OT - diabetes OT - generalized estimating equations OT - nomogram OT - prediabetes OT - predictive model COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/10/03 06:31 MHDA- 2025/10/03 12:33 PMCR- 2025/09/17 CRDT- 2025/10/03 05:24 PHST- 2025/05/19 00:00 [received] PHST- 2025/08/11 00:00 [accepted] PHST- 2025/10/03 12:33 [medline] PHST- 2025/10/03 06:31 [pubmed] PHST- 2025/10/03 05:24 [entrez] PHST- 2025/09/17 00:00 [pmc-release] AID - 10.3389/fendo.2025.1626925 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2025 Sep 17;16:1626925. doi: 10.3389/fendo.2025.1626925. eCollection 2025. PMID- 41040055 OWN - NLM STAT- MEDLINE DCOM- 20260105 LR - 20260512 IS - 1552-4833 (Electronic) IS - 1552-4825 (Linking) VI - 200 IP - 2 DP - 2026 Feb TI - The Head Circumference Height Index (HCH-I) to Quantify Relative Macrocephaly and Aid Identification of Hypochondroplasia in Children. PG - 353-359 LID - 10.1002/ajmg.a.64266 [doi] AB - Hypochondroplasia (HCH) is a rare skeletal dysplasia caused by pathogenic variants in the FGFR3 gene. We hypothesized that the relative disproportion between head circumference and height in HCH might be diagnostically informative and generated a simple index of head-stature disproportion to help pediatricians diagnose HCH. The Head Circumference Height Index (HCH-I), based on formal statistical principles, is defined as height Z-score - 1/2 head circumference Z-score, with the Z-scores based here on the UK90 growth reference. An HCH-I below the cut-off of -2 indicates substantial head-height disproportion. We validated the index by comparing children diagnosed with HCH (n = 364), using data from the recent European HCH growth charts, to children from the Cambridge Infant Growth Study (CIGS) (n = 4620). The mean (SD) HCH-I was -3.0 (1.2) in the HCH cohort, compared to -0.2 (0.9) in the CIGS cohort. An HCH-I below -2 correctly identified 78% of children with HCH, while only 2.4% of CIGS children fell below the cut-off. An HCH-I below -2 identifies children with head-height disproportion who may have HCH or another genetic disorder. The index is deliberately simple to calculate and should prove useful in clinical practice. CI - (c) 2025 The Author(s). American Journal of Medical Genetics Part A published by Wiley Periodicals LLC. FAU - Cheung, Moira S AU - Cheung MS AUID- ORCID: 0000-0003-0742-7595 AD - Great Ormond Street Hospital NHS Foundation Trust, Department of Paediatric Endocrinology, London, UK. AD - UCL Great Ormond Street Institute of Child Health, London, UK. FAU - Lanzafame, Ruggero AU - Lanzafame R AUID- ORCID: 0009-0009-5378-1895 AD - Great Ormond Street Hospital NHS Foundation Trust, Department of Paediatric Endocrinology, London, UK. FAU - Low, Karen J AU - Low KJ AUID- ORCID: 0000-0002-4975-9363 AD - Department of Clinical Genetics, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK. AD - Centre for Academic Child Health, Bristol Medical School, University of Bristol, Bristol, UK. FAU - Cole, Tim J AU - Cole TJ AUID- ORCID: 0000-0001-5711-8200 AD - UCL Great Ormond Street Institute of Child Health, London, UK. LA - eng GR - GOSH Charity/ GR - 302303/National Institute for Health and Care Research/ GR - National Institute for Health and Care Research/ PT - Journal Article DEP - 20251003 PL - United States TA - Am J Med Genet A JT - American journal of medical genetics. Part A JID - 101235741 RN - EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 3) RN - EC 2.7.10.1 (FGFR3 protein, human) RN - Hypochondroplasia SB - IM MH - Humans MH - *Lordosis/diagnosis/genetics/pathology MH - *Dwarfism/diagnosis/genetics/pathology MH - Female MH - Male MH - Child MH - *Receptor, Fibroblast Growth Factor, Type 3/genetics MH - *Limb Deformities, Congenital/diagnosis/genetics/pathology MH - Child, Preschool MH - Infant MH - *Megalencephaly/diagnosis/genetics/pathology MH - *Bone and Bones/abnormalities/pathology MH - Body Height/genetics MH - *Head MH - Adolescent MH - Growth Charts MH - Cephalometry OTO - NOTNLM OT - Z-score OT - head circumference OT - height OT - hypochondroplasia OT - index OT - macrocephaly EDAT- 2025/10/03 06:31 MHDA- 2026/01/05 12:47 CRDT- 2025/10/03 05:03 PHST- 2025/08/05 00:00 [revised] PHST- 2025/06/14 00:00 [received] PHST- 2025/09/13 00:00 [accepted] PHST- 2026/01/05 12:47 [medline] PHST- 2025/10/03 06:31 [pubmed] PHST- 2025/10/03 05:03 [entrez] AID - 10.1002/ajmg.a.64266 [doi] PST - ppublish SO - Am J Med Genet A. 2026 Feb;200(2):353-359. doi: 10.1002/ajmg.a.64266. Epub 2025 Oct 3. PMID- 41039386 OWN - NLM STAT- MEDLINE DCOM- 20251003 LR - 20251117 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Oct 2 TI - Impact of cut-point methods on classification of physical activity and sedentary behaviour of toddlers. PG - 3290 LID - 10.1186/s12889-025-24636-6 [doi] LID - 3290 AB - BACKGROUND: Classification of physical activity (PA) depends on the cut-point method used to allocate PA counts from accelerometer measurements. This study investigates how three validated cut-point methods affect the time spent in various levels of PA and sedentary behaviour (SB), and how they impact toddlers estimated adherence to PA guidelines. METHODS: PA was assessed using an ActiGraph wGT3X-BT accelerometer in a cohort of 653 two-year-old children participating in the Toddler Milk Intervention study. Children wearing the ActiGraph for at least four days, with a minimum of six hours wear-time per day, were included. Time spent in SB and different activity levels were estimated according to three cut-point methods and were standardized to individual mean wear-time. We used one cut-point method based on the vertical axis (VA) (Trost VA), with an epoch length of 15 s and two cut-point methods based on either the VA (Costa VA) or on the vector magnitude (VM) (Costa VM) with an epoch length of five seconds. Estimates of SB and PA for each method were compared with repeated measures ANOVA. RESULTS: The time toddlers spent in PA was significantly different depending on the cut-point methods. Costa VM classified on average 62 min (95% CI 61, 64] more per day as SB and 57 min (95% CI -58, -56] less per day as LPA compared to Trost VA (both p < 0.0001). For MVPA, the mean difference between Costa VA and Trost VA was 6.8 min (95% CI -7, -6; p < 0.0001). Concurrently, the proportion of children meeting the WHO recommendation of 180 min of total PA differed between cut-point methods, with 86% according to Costa VM and 97% according to Trost VA. CONCLUSIONS: The time toddlers engage in different intensities of PA is significantly determined by the selection of cut-point method. Notably, the use of a different cut-point method leads up to a 10% difference in the estimated time spent in LPA and SB, but only a 1% difference of moderate-vigorous PA. These differences change the estimated adherence to recommendations. Future research is needed to standardize the data processing methods for better comparability between studies analysing toddlers' PA. REGISTRY: ClinicalTrials.gov, TRN: NCT02907502, Registration Date: 31 August 2016. CI - (c) 2025. The Author(s). FAU - Ferry, Jill Marie AU - Ferry JM AD - Department of Paediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, Munich, Germany. AD - German Center for Child and Adolescent Health, site Munich, Munich, Germany. FAU - Escribano, Joaquin AU - Escribano J AD - Department of Paediatrics, Nutrition and Development Research Unit, Universitat Rovira i Virgili, IISPV, Reus, Spain. AD - Department of Paediatric, Hospital Universitari Sant Joan de Reus , Reus, Spain. FAU - Gispert-LLaurado, Mariona AU - Gispert-LLaurado M AD - Department of Paediatrics, Nutrition and Development Research Unit, Universitat Rovira i Virgili, IISPV, Reus, Spain. FAU - Koletzko, Berthold AU - Koletzko B AD - Department of Paediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, Munich, Germany. AD - German Center for Child and Adolescent Health, site Munich, Munich, Germany. FAU - Grote, Veit AU - Grote V AD - Department of Paediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, Munich, Germany. Veit.Grote@med.uni-muenchen.de. AD - German Center for Child and Adolescent Health, site Munich, Munich, Germany. Veit.Grote@med.uni-muenchen.de. LA - eng SI - ClinicalTrials.gov/NCT02907502 PT - Journal Article PT - Randomized Controlled Trial DEP - 20251002 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Child, Preschool MH - Female MH - Humans MH - Male MH - *Accelerometry/methods MH - *Exercise MH - *Sedentary Behavior PMC - PMC12492789 OTO - NOTNLM OT - Accelerometer OT - ActiGraph OT - Cut-points OT - Physical activity OT - Sedentary behaviour OT - Toddlers COIS- Declarations. Ethics approval and consent to participate: Ethics approval was obtained from the ethical committees of the LMU University Hospital Munich, Germany (Nr. 555 - 15) and at Institut d'Investigacio Sanitaria Pere Virgili, Reus, Spain (Ref. CEIm IISPV 013/2016). The ethics committees at the participating centers reviewed and accepted the trial protocol, and parents provided written informed consent as a prerequisite of their child's participation. All research was conducted in accordance with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/10/03 00:29 MHDA- 2025/10/03 06:31 PMCR- 2025/10/02 CRDT- 2025/10/02 23:46 PHST- 2025/05/13 00:00 [received] PHST- 2025/08/26 00:00 [accepted] PHST- 2025/10/03 06:31 [medline] PHST- 2025/10/03 00:29 [pubmed] PHST- 2025/10/02 23:46 [entrez] PHST- 2025/10/02 00:00 [pmc-release] AID - 10.1186/s12889-025-24636-6 [pii] AID - 24636 [pii] AID - 10.1186/s12889-025-24636-6 [doi] PST - epublish SO - BMC Public Health. 2025 Oct 2;25(1):3290. doi: 10.1186/s12889-025-24636-6. PMID- 41039367 OWN - NLM STAT- MEDLINE DCOM- 20251003 LR - 20251005 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Oct 2 TI - Health commitment's associations with health outcomes are independent of health behaviours: insights from a cross-sectional population health survey in Singapore. PG - 3299 LID - 10.1186/s12889-025-24610-2 [doi] LID - 3299 AB - BACKGROUND: An individual's commitment to health is a crucial component of their healthcare engagement. However, research is scarce that has systematically examined the association between commitment and health behaviours as well as health outcomes. We conducted this study to examine their associations in a representative community-dwelling adult population in Singapore. METHODS: This cross-sectional study analysed data from the Khoo Teck Puat Hospital and Yishun Community Hospital's Population Health Survey 2022, which interviewed a representative sample of community-dwelling residents aged 18 years and above in Singapore's Northern Region between July and December 2022. Health commitment was assessed using the validated Commitment subscale of the Altarum Consumer Engagement (ACE) Measure. Assessment of health behaviours encompassed smoking status, alcohol consumption, vegetable and fruit consumption, sleep duration and physical activity. Additionally, various health outcomes spanning physical, mental, and social health domains, as well as healthcare utilisation indicators, were collected. Social-demographic factors associated with commitment were identified via multiple linear regression. Multiple logistic or ordinal logistic regression models were employed to examine the associations between commitment and individual health behaviours and outcomes, adjusting for basic demographic variables. RESULTS: The mean age of the participants was 49.7 years, ranging from 18 to 94 years, with 51% being females, and 68.2% belonging to the Chinese ethnicity. The results identified age group, ethnicity, marital status, housing type, monthly household income, and number of medications as factors associated with commitment. Significant associations were found between health commitment and various health behaviours. Furthermore, higher health commitment was consistently associated with an increased likelihood of subjective health outcomes (odds ratios range:1.17-1.28) and a reduced likelihood of healthcare utilisation (odds ratios range: 0.91-0.93), even after adjusting for health behaviours. CONCLUSIONS: These findings underscore the importance of assessing and addressing health commitment in healthcare practice and policy. Strategies to enhance health commitment hold potential for improving health behaviours and health outcomes, thereby contributing to overall well-being. However, it is important to note that the cross-sectional nature of this study does not allow for confirmation of causal pathways. Hence, longitudinal studies are needed to further clarify these relationships and their potential impact on overall well-being. CI - (c) 2025. The Author(s). FAU - Ge, Lixia AU - Ge L AUID- ORCID: 0000-0001-8080-7020 AD - Health Services & Outcomes Research, National Healthcare Group, 1 Mandalay Rd, Singapore, 308205, Singapore. lixia.ge@nhghealth.com.sg. FAU - Hu, Yun AU - Hu Y AD - Khoo Teck Puat Hospital and Yishun Community Hospital, 90 Yishun Central, Singapore, 768828, Singapore. FAU - Tan, Annie AU - Tan A AD - Khoo Teck Puat Hospital and Yishun Community Hospital, 90 Yishun Central, Singapore, 768828, Singapore. FAU - Teo, Cherlyen AU - Teo C AD - Khoo Teck Puat Hospital and Yishun Community Hospital, 90 Yishun Central, Singapore, 768828, Singapore. FAU - Yap, Chun Wei AU - Yap CW AD - Health Services & Outcomes Research, National Healthcare Group, 1 Mandalay Rd, Singapore, 308205, Singapore. FAU - Ng, Yeuk Fan AU - Ng YF AUID- ORCID: 0000-0003-3303-3223 AD - Khoo Teck Puat Hospital and Yishun Community Hospital, 90 Yishun Central, Singapore, 768828, Singapore. ng.yeuk.fan@nhghealth.com.sg. AD - Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore. ng.yeuk.fan@nhghealth.com.sg. LA - eng GR - PHG20.P.Y.2.2/National Healthcare Group/ PT - Journal Article DEP - 20251002 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Singapore MH - Middle Aged MH - Male MH - Adult MH - *Health Behavior MH - Aged MH - Adolescent MH - Young Adult MH - Aged, 80 and over MH - Health Surveys PMC - PMC12492676 OTO - NOTNLM OT - Commitment OT - Health behaviours OT - Health outcomes OT - Healthcare utilisation OT - Mental health OT - Physical health OT - Population health survey OT - Social health COIS- Declarations. Ethics approval and consent to participate: This study received ethics approval from the National Healthcare Group Domain Specific Review Board (Reference Number: 2021/00883) and was conducted in strict adherence to the principles outlined in the Declaration of Helsinki. All participants were fully informed about the study's purpose, procedures, potential benefits, risks and side effects, and data confidentiality. Written consent was obtained from all participants prior to the commencement of data collection. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/10/03 00:29 MHDA- 2025/10/03 06:32 PMCR- 2025/10/02 CRDT- 2025/10/02 23:45 PHST- 2024/06/26 00:00 [received] PHST- 2025/08/25 00:00 [accepted] PHST- 2025/10/03 06:32 [medline] PHST- 2025/10/03 00:29 [pubmed] PHST- 2025/10/02 23:45 [entrez] PHST- 2025/10/02 00:00 [pmc-release] AID - 10.1186/s12889-025-24610-2 [pii] AID - 24610 [pii] AID - 10.1186/s12889-025-24610-2 [doi] PST - epublish SO - BMC Public Health. 2025 Oct 2;25(1):3299. doi: 10.1186/s12889-025-24610-2. PMID- 41039294 OWN - NLM STAT- MEDLINE DCOM- 20251003 LR - 20260925 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Oct 2 TI - Cardiovascular health behaviour, acrylamide exposure and health risk assessment of adolescents. PG - 3302 LID - 10.1186/s12889-025-24053-9 [doi] LID - 3302 AB - BACKGROUND: The presence of acrylamide at different levels in many foods in our daily diet is a very alarming situation for public health. The aim of this study was to evaluate the acrylamide exposure of adolescents resulting from the consumption of French fries in terms of carcinogenic and non-carcinogenic health risks and to reveal its relationship with heart health. METHODS: This study was conducted on adolescents aged 13-15 years living in Turkiye. Firstly, a scale with tested reliability was used to determine the heart health behaviours of adolescents. Then, the acrylamide exposure levels were determined according to the deterministic model by taking the french fries consumption data of the adolescents for a retrospective 24-hour period. Acrylamide exposure level was then evaluated in terms of carcinogenic and non-carcinogenic health risks. Statistical differences between the groups were analysed by independent t test, Mann Whitney U test, Welch Test and Kruskal Wallis Test. Spearman's rho correlation coefficient was used to determine the degree of non-causal relationships. RESULTS: All adolescents showed normal cardiovascular behaviour (63 +/- 11). The acrylamide exposure level of all adolescents from French fries consumption ranged between 0-2.60 microg/kg/day. The mean THQ (Target Hazard Quotient) value for all adolescents was 0.11 +/- 0.27 and the mean CR (Carcinogenic risk) value was 1.10E-05 +/- 2.69E-04. Since the THQ value was lower than the reference value, the consumption of French fries was considered safe for adolescents. However, the CR value indicates the presence of potential carcinogenic health risks. There was no statistical difference between the acrylamide exposure level, THQ and CR values according to the cardiovascular behaviour scores of adolescents, whereas a statistical difference was found only between the BMI (body mass index) subcategories. CONCLUSION: The acrylamide exposure level calculated for adolescents is relatively high compared to other studies in the literature. Carcinogenic health risks associated with the consumption of French fries have been identified. It is thought that the results of the study will contribute to the studies and strategies to be developed to reduce dietary acrylamide exposure. CI - (c) 2025. The Author(s). FAU - Metin Karaaslan, Mehtap AU - Metin Karaaslan M AUID- ORCID: 0000-0002-1575-3799 AD - Department of Nursing, Faculty of Health Sciences, Recep Tayyip Erdogan University, Rize, Turkiye. m.metinkaraaslan@gmail.com. FAU - Basaran, Burhan AU - Basaran B AUID- ORCID: 0000-0001-6506-6113 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Recep Tayyip Erdogan University, Rize, Turkiye. LA - eng GR - 02025001006243/Recep Tayyip Erdogan University Development Foundation/ GR - 02025001006243/Recep Tayyip Erdogan University Development Foundation/ PT - Journal Article DEP - 20251002 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - 20R035KLCI (Acrylamide) SB - IM MH - Humans MH - Adolescent MH - *Acrylamide/analysis/toxicity/adverse effects MH - Male MH - Female MH - Risk Assessment MH - *Health Behavior MH - Retrospective Studies MH - *Cardiovascular Diseases MH - *Food Contamination/analysis MH - *Adolescent Behavior PMC - PMC12492714 OTO - NOTNLM OT - Acrylamide OT - Carcinogenic risk OT - Cardiovascular diseases OT - Dietary acrylamide exposure OT - Health risk OT - Risk assessment COIS- Declarations. Ethics approval and consent to participate: This study was conducted under the "Principles of the Declaration of Helsinki". Prior to the study, written permission was obtained from the Non-Interventional Clinical Research Ethics Committee of Recep Tayyip Erdogan University Faculty of Medicine [E-40465587-050.01.04-590 number and decision number 2023/19, date 25.01.2023]. In addition, institutional permission was obtained from Rize (Turkey) Directorate of National Education [E-57774812-605.01-49221528 number]. Helsinki principles were followed throughout the study. Since the data were collected from individuals under the age of 18, students were informed about the study the day before the study and a parental informed consent form was distributed. Questionnaires were administered to students who signed the informed consent form and volunteered to participate in the study. Competing interests: The authors declare no competing interests. EDAT- 2025/10/03 00:29 MHDA- 2025/10/03 06:31 PMCR- 2025/10/02 CRDT- 2025/10/02 23:43 PHST- 2025/02/07 00:00 [received] PHST- 2025/07/18 00:00 [accepted] PHST- 2025/10/03 06:31 [medline] PHST- 2025/10/03 00:29 [pubmed] PHST- 2025/10/02 23:43 [entrez] PHST- 2025/10/02 00:00 [pmc-release] AID - 10.1186/s12889-025-24053-9 [pii] AID - 24053 [pii] AID - 10.1186/s12889-025-24053-9 [doi] PST - epublish SO - BMC Public Health. 2025 Oct 2;25(1):3302. doi: 10.1186/s12889-025-24053-9. PMID- 41038394 OWN - NLM STAT- MEDLINE DCOM- 20251207 LR - 20260518 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 217 DP - 2026 Feb 1 TI - Sensory sensitivity and food disgust in ARFID presentations across ages. PG - 108329 LID - S0195-6663(25)00482-9 [pii] LID - 10.1016/j.appet.2025.108329 [doi] AB - Sensory sensitivity plays a pivotal role in avoidant/restrictive food intake disorder (ARFID), and food disgust is widely accepted as a key factor in food avoidance across ages. However, their relationship remains unclear in ARFID in general and across its main presentations, picky eating, fear of aversive consequences, and lack of interest. Therefore, this cross-sectional study examined whether food disgust acted as a mediator of the relationship between sensory sensitivity and ARFID symptoms in children and adults. Parents and adults from the community participated in an online survey on children's and adults' sensory sensitivity, food disgust, and ARFID symptoms according to the three main presentations based on validated questionnaires. Data from 270 parents (children aged 2-17 years, 60.4% male) and 491 adults (18-73 years, 76.8% female) were analyzed. Consistently across ages, positive associations between food disgust and picky eating (medium to large effect) and fear of aversive consequences (small effect) were observed. Food disgust mediated (i.e., weakened) the association between sensory sensitivity and both picky eating (large effect) and fear of aversive consequences (small effect), but did not mediate this association for lack of interest. The results showed that different etiological mechanisms may play a role in the main presentations of ARFID. Food disgust was found to be particularly relevant for ARFID-picky eating in both children and adults, but was less relevant for ARFID-fear of aversive consequences and ARFID-lack of interest. Longitudinal studies are needed to explore the directionality between sensory sensitivity, food disgust, and ARFID symptoms. Addressing food disgust in therapeutic approaches for ARFID warrants further investigation. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Kramer, Lena AU - Kramer L AD - Department of Psychosomatic Medicine and Psychotherapy, Behavioral Medicine Research Unit, Integrated Research and Treatment Center AdiposityDiseases, Leipzig University Medical Center, Leipzig, Germany. Electronic address: lena.kramer@medizin.uni-leipzig.de. FAU - Nettlau, Alexander AU - Nettlau A AD - Department of Psychosomatic Medicine and Psychotherapy, Behavioral Medicine Research Unit, Integrated Research and Treatment Center AdiposityDiseases, Leipzig University Medical Center, Leipzig, Germany. Electronic address: alexander.nettlau@medizin.uni-leipzig.de. FAU - Merz, Anne-Kathrin AU - Merz AK AD - Department of Psychosomatic Medicine and Psychotherapy, Behavioral Medicine Research Unit, Integrated Research and Treatment Center AdiposityDiseases, Leipzig University Medical Center, Leipzig, Germany. Electronic address: anne-kathrin.merz@medizin.uni-leipzig.de. FAU - Martin, Annick AU - Martin A AD - Leipzig University Medical Center, Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, Leipzig, Germany. Electronic address: annick.martin@uniklinik-leipzig.de. FAU - Hilbert, Anja AU - Hilbert A AD - Department of Psychosomatic Medicine and Psychotherapy, Behavioral Medicine Research Unit, Integrated Research and Treatment Center AdiposityDiseases, Leipzig University Medical Center, Leipzig, Germany; German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden, Leipzig, Germany. Electronic address: anja.hilbert@medizin.uni-leipzig.de. FAU - Schmidt, Ricarda AU - Schmidt R AD - Department of Psychosomatic Medicine and Psychotherapy, Behavioral Medicine Research Unit, Integrated Research and Treatment Center AdiposityDiseases, Leipzig University Medical Center, Leipzig, Germany; German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden, Leipzig, Germany. Electronic address: ricarda.schmidt@medizin.uni-leipzig.de. LA - eng PT - Journal Article DEP - 20250930 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Male MH - Female MH - *Disgust MH - Adult MH - Child MH - Adolescent MH - Middle Aged MH - Cross-Sectional Studies MH - Young Adult MH - Aged MH - Child, Preschool MH - *Avoidant Restrictive Food Intake Disorder/psychology MH - Surveys and Questionnaires MH - Age Factors MH - Fear/psychology MH - *Feeding Behavior/psychology MH - Food Preferences/psychology MH - Parents/psychology OTO - NOTNLM OT - ARFID OT - Eating disorder OT - Feeding disorder OT - Food disgust OT - Mediation OT - Sensory sensitivity COIS- Declaration of competing interest The authors declare no conflicts of interest. EDAT- 2025/10/03 00:29 MHDA- 2025/12/08 01:36 CRDT- 2025/10/02 19:27 PHST- 2025/05/15 00:00 [received] PHST- 2025/08/19 00:00 [revised] PHST- 2025/09/29 00:00 [accepted] PHST- 2025/12/08 01:36 [medline] PHST- 2025/10/03 00:29 [pubmed] PHST- 2025/10/02 19:27 [entrez] AID - S0195-6663(25)00482-9 [pii] AID - 10.1016/j.appet.2025.108329 [doi] PST - ppublish SO - Appetite. 2026 Feb 1;217:108329. doi: 10.1016/j.appet.2025.108329. Epub 2025 Sep 30. PMID- 41037119 OWN - NLM STAT- MEDLINE DCOM- 20251002 LR - 20261010 IS - 1437-9813 (Electronic) IS - 0179-0358 (Linking) VI - 41 IP - 1 DP - 2025 Oct 2 TI - Initiation of oral intake in neonates with surgical necrotizing enterocolitis: a road map. PG - 307 LID - 10.1007/s00383-025-06202-8 [doi] AB - PURPOSE: Necrotizing enterocolitis (NEC) is a severely life-threatening gastrointestinal emergency in newborns, especially when surgical intervention is needed. The ideal time for resuming oral feeding after surgery is still unclear, leading to variations in practice and prolonged parenteral nutrition. This study aims to develop and validate a scoring system to determine the best time to reintroduce oral feeding in neonates following surgical NEC. METHODS: A multicenter retrospective study was conducted from 2016 to 2024, including 500 neonates with surgical NEC (Bell's Stage III-IV). Patients were divided into early (5 days), intermediate (8-14 days), and delayed (>/= 15 days) feeding groups. A predictive score was constructed on 100 patients using eight preoperative, intraoperative, and postoperative variables. Validation was performed on an independent cohort of 400 patients. RESULTS: The scoring system demonstrated strong predictive accuracy (AUC = 0.967). Variables such as localized pneumatosis, absence of portal venous gas, higher platelet count, no second-look laparotomy, and early normalization of nasogastric aspirates and lab parameters were significantly associated with early feeding tolerance (p < 0.05). Validation confirmed reproducibility across cohorts without NEC recurrence or feeding-related complications. CONCLUSION: We present a validated, clinically practical scoring system to guide early oral intake initiation after NEC surgery. It enables stratified decision-making, reduces reliance on parenteral nutrition, and enhances postoperative recovery. CI - (c) 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Kurdi, Mazen Omar AU - Kurdi MO AD - Pediatric Surgery Unit, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Shehata, Mohamed Ali AU - Shehata MA AUID- ORCID: 0000-0003-3913-1836 AD - Department of General Surgery, Pediatric Surgery Unit, Faculty of Medicine, Tanta University, Tanta University Hospitals, El-Geish Street, Tanta, 31257, Egypt. Mohamedshehata81@hotmail.com. FAU - Eldessouki, Nagi Ibrahim AU - Eldessouki NI AD - Department of General Surgery, Pediatric Surgery Unit, Faculty of Medicine, Tanta University, Tanta University Hospitals, El-Geish Street, Tanta, 31257, Egypt. FAU - Mukhtar, Ahmed AU - Mukhtar A AD - Pediatric Surgery Unit, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Al-Wassia, Heidi AU - Al-Wassia H AD - Pediatric Department, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Bamehrez, Maha AU - Bamehrez M AD - Pediatric Department, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Khirallah, Mohammad Gharieb AU - Khirallah MG AUID- ORCID: 0000-0003-4261-7474 AD - Department of General Surgery, Pediatric Surgery Unit, Faculty of Medicine, Tanta University, Tanta University Hospitals, El-Geish Street, Tanta, 31257, Egypt. Mohamed.khirallah@med.tanta.edu.eg. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20251002 PL - Germany TA - Pediatr Surg Int JT - Pediatric surgery international JID - 8609169 SB - IM MH - Humans MH - *Enterocolitis, Necrotizing/surgery MH - Retrospective Studies MH - Infant, Newborn MH - Male MH - Female MH - Reproducibility of Results MH - *Enteral Nutrition/methods MH - *Eating OTO - NOTNLM OT - Enteral feeding OT - Intestinal recovery OT - Necrotizing enterocolitis OT - Neonatal surgery OT - Postoperative nutrition OT - Predictive model OT - Preterm infants OT - Scoring system COIS- Declarations. Conflict of interest: The authors declare that there are no competing interests. Ethical approval: This study was approved by the Research Ethics committee, Federal Wide Assurance (FWA), FWA00022834, IRB0010038, Faculty of Medicine, Tanta University, Egypt on February 2024, code (code 36264 PR532/2/24; and from King Abdelaziz University (NCBE Registration No: (HA-02-J-008) (Reference No 76-24). Consent to participation: All patients included in this study gave written informed consent to participate in this research by their parent or legal guardian. Consent for publication: All patients included in this research gave written informed consent to publish the data contained within this study. If the patient was less than 16 years old, deceased, or unconscious when consent for publication was requested, written informed consent for the publication of this data was given by their parent or legal guardian. EDAT- 2025/10/02 12:32 MHDA- 2025/10/02 12:33 CRDT- 2025/10/02 11:14 PHST- 2025/06/12 00:00 [received] PHST- 2025/09/09 00:00 [accepted] PHST- 2025/10/02 12:33 [medline] PHST- 2025/10/02 12:32 [pubmed] PHST- 2025/10/02 11:14 [entrez] AID - 10.1007/s00383-025-06202-8 [pii] AID - 10.1007/s00383-025-06202-8 [doi] PST - epublish SO - Pediatr Surg Int. 2025 Oct 2;41(1):307. doi: 10.1007/s00383-025-06202-8. PMID- 41034800 OWN - NLM STAT- MEDLINE DCOM- 20251002 LR - 20251005 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Oct 1 TI - Association between ultra-processed food consumption, carbon footprint awareness and sustainable and healthy eating behaviors in adult: a cross-sectional study. PG - 3283 LID - 10.1186/s12889-025-22918-7 [doi] LID - 3283 AB - BACKGROUND: Ultra-processed food (UPF) consumption is rising globally, posing significant health and environmental risks. While studies have extensively examined ultra-processed food (UPF) consumption, they often overlook the factors influencing awareness and behavioral shifts toward sustainable and healthy eating. This study aims to examine the relationship between UPF consumption, carbon footprint awareness, and sustainable and healthy eating behaviors in adults. METHODS: This cross-sectional study was conducted with 1748 adults aged 18-65 years. Participants' Eating Behaviors and awareness levels were assessed using three validated scales: the Sustainable and Healthy Eating Behaviors Scale (SHEBS), the Highly Processed Food Consumption Screening Questionnaire (sQ-HPF), and the Carbon Footprint Awareness Scale (CFAS). Pearson correlation and Linear regression analyses were used to assess associations. RESULTS: The mean age of participants was 29.4 +/- 12.16 years and 55.7% had high UPF consumption. Participants' general characteristics were assessed through a questionnaire.Pearson correlation analyses revealed that UPF consumption (sQ-HPF score) was negatively correlated with carbon footprint awareness (CFAS) (r = -0.184, p < 0.001) and sustainable and healthy eating behaviors (SHEBS) (r =-0.296, p < 0.001). A strong positive correlation was observed between CFAS and SHEBS scores (r = 0.653, p < 0.001), including all SHEBS sub-dimensions (r = 0.325-0.911, p < 0.001). Linear regression analysis indicated that age (beta = -0.293), CFAS (beta = -0.264), and SHEBS (beta=-0.230) significantly predicted UPF consumption (R(2)=0.373, p < 0.001). Furthermore, CFAS was predicted by SHEBS (beta = 0.658) and UPF consumption (beta = -0.141) (R(2) = 0.672), while SHEBS was predicted by CFAS (beta = 0.644) and UPF consumption (beta = -0.142) (R(2) = 0.680, p < 0.001). CONCLUSIONS: UPF consumption is inversely associated with both carbon footprint awareness and sustainable, healthy eating behaviors. Strengthening environmental awareness and promoting sustainable eating practices may be effective strategies for reducing UPF intake in adults. These findings underscore the importance of integrative public health efforts targeting both nutritional and environmental dimensions. CI - (c) 2025. The Author(s). FAU - Ekici, Emine Merve AU - Ekici EM AUID- ORCID: 0000-0001-5409-6309 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Faculty, University of Health Sciences, Ankara, Turkey. FAU - Eroglu, Fatma Elif AU - Eroglu FE AUID- ORCID: 0000-0003-0394-4640 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Faculty, University of Health Sciences, Ankara, Turkey. fatmaelif.eroglu@sbu.edu.tr. FAU - Mengi Celik, Ozge AU - Mengi Celik O AUID- ORCID: 0000-0002-0298-9591 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Faculty, University of Health Sciences, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20251001 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Adult MH - Female MH - Male MH - Middle Aged MH - *Diet, Healthy/statistics & numerical data/psychology MH - Young Adult MH - *Carbon Footprint/statistics & numerical data MH - Aged MH - Adolescent MH - *Feeding Behavior/psychology MH - Surveys and Questionnaires MH - *Fast Foods/statistics & numerical data MH - Food, Processed PMC - PMC12486750 OTO - NOTNLM OT - Adults OT - Carbon footprint awareness OT - Sustainable and healthy eating behaviors OT - Ultra processed food COIS- Declarations. Ethics statement: All procedures performed in this study involving human participants were conducted in accordance with the ethical principles of the institutional research committee and the 1964 Helsinki Declaration and its later revisions or equivalent ethical standards. The study was conducted with ethical approval from the Health Sciences University Gulhane Scientific Research Ethics Committee with decision number 2024/533. Informed consent was obtained from all individuals participating in the study, indicating that they participated in the study voluntarily. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/10/02 00:28 MHDA- 2025/10/02 06:28 PMCR- 2025/10/01 CRDT- 2025/10/01 23:59 PHST- 2025/03/18 00:00 [received] PHST- 2025/04/24 00:00 [accepted] PHST- 2025/10/02 06:28 [medline] PHST- 2025/10/02 00:28 [pubmed] PHST- 2025/10/01 23:59 [entrez] PHST- 2025/10/01 00:00 [pmc-release] AID - 10.1186/s12889-025-22918-7 [pii] AID - 22918 [pii] AID - 10.1186/s12889-025-22918-7 [doi] PST - epublish SO - BMC Public Health. 2025 Oct 1;25(1):3283. doi: 10.1186/s12889-025-22918-7. PMID- 41034750 OWN - NLM STAT- MEDLINE DCOM- 20251002 LR - 20251005 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Oct 1 TI - Assessing physical activity literacy and practices among adults in the United Arab Emirates: a cross-sectional study. PG - 3275 LID - 10.1186/s12889-025-24490-6 [doi] LID - 3275 AB - BACKGROUND: Physical inactivity among adults in the United Arab Emirates (UAE) is a growing public health concern, contributing to chronic diseases and increased healthcare burdens. Understanding physical activity literacy (PAL) and behaviour, along with associated sociodemographic factors, is essential for designing effective interventions. METHODS: A cross-sectional study was conducted among 630 adults in UAE, using a validated self-administered questionnaire. The tool assessed knowledge of physical activity and its health benefits, engagement in physical activity, and sociodemographic characteristics. Knowledge scores were categorized as 'good' (>/= 6) and 'poor' (/=34 weeks' gestation or up to 3 days post delivery with pre-pregnancy overweight/obesity (body mass index (BMI) >23 kg/m(2)) and/or a diagnosis of diabetes. Caregiver-infant pairs will be randomised to the FLAGs intervention or control group. Over 12 months, both groups will receive standard infant care. The intervention group will undergo regular assessments via the FLAGs web app built-in assessment tool, assessing infant feeding practices, sedentary behaviour and physical activity. The intervention group will also receive FLAGs personalised guidance and weekly digital nudges. Maternal and infant data will be collected at baseline and at 12 months. Primary outcomes are infant BMI, weight-for-length and body composition at 12 months. Secondary outcomes include lifestyle behaviours and eating habits assessed through validated questionnaires when the infants are 1 year old. We will perform both intention-to-treat and per protocol analysis. ETHICS AND DISSEMINATION: Ethical approval has been obtained from the SingHealth Centralised Institutional Review Board (Ref: 2024/3224). Written informed consent will be obtained from all participants. Study findings will be disseminated via peer-reviewed publications and academic conferences, with de-identified data available on reasonable request. This trial is registered on ClinicalTrials.gov (ID: NCT06457750). TRIAL REGISTRATION NUMBER: NCT06457750. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Chan, Daniel AU - Chan D AUID- ORCID: 0000-0001-8191-5330 AD - Endocrinology Service, KK Women's and Children's Hospital, Singapore daniel.chan@duke-nus.edu.sg. AD - Duke-NUS Medical School, Singapore. AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. FAU - Leong, Kylie AU - Leong K AD - Department of Paediatric Medicine, KK Women's and Children's Hospital, Singapore. FAU - Ong, Chengsi AU - Ong C AD - Duke-NUS Medical School, Singapore. AD - Department of Dietetics, KK Women's and Children's Hospital, Singapore. FAU - Ku, Chee Wai AU - Ku CW AD - Duke-NUS Medical School, Singapore. AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore. FAU - Chan, Jerry Kok Yen AU - Chan JKY AD - Duke-NUS Medical School, Singapore. AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore. FAU - Chua, Mei Chien AU - Chua MC AD - Duke-NUS Medical School, Singapore. AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. AD - Department of Neonatology, KK Women's and Children's Hospital, Singapore. FAU - Yap, Fabian AU - Yap F AD - Endocrinology Service, KK Women's and Children's Hospital, Singapore. AD - Duke-NUS Medical School, Singapore. AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. FAU - Loy, See Ling AU - Loy SL AD - Duke-NUS Medical School, Singapore. AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore. LA - eng SI - ClinicalTrials.gov/NCT06457750 PT - Clinical Trial Protocol PT - Journal Article DEP - 20250930 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Mobile Applications MH - Female MH - Infant MH - *Feeding Behavior MH - *Pediatric Obesity/prevention & control MH - *Life Style MH - *Mothers MH - Randomized Controlled Trials as Topic MH - Infant, Newborn MH - Singapore MH - Exercise MH - Risk Factors MH - Pregnancy PMC - PMC12496037 OTO - NOTNLM OT - Community child health OT - PAEDIATRICS OT - PUBLIC HEALTH COIS- Competing interests: None declared. EDAT- 2025/10/02 00:29 MHDA- 2025/10/02 00:30 PMCR- 2025/09/30 CRDT- 2025/10/01 21:04 PHST- 2025/10/02 00:30 [medline] PHST- 2025/10/02 00:29 [pubmed] PHST- 2025/10/01 21:04 [entrez] PHST- 2025/09/30 00:00 [pmc-release] AID - bmjopen-2025-101684 [pii] AID - 10.1136/bmjopen-2025-101684 [doi] PST - epublish SO - BMJ Open. 2025 Sep 30;15(9):e101684. doi: 10.1136/bmjopen-2025-101684. PMID- 41029841 OWN - NLM STAT- MEDLINE DCOM- 20251001 LR - 20251003 IS - 1756-0500 (Electronic) IS - 1756-0500 (Linking) VI - 18 IP - 1 DP - 2025 Sep 30 TI - Community-based interventions to improve child nutrition knowledge, attitudes and practices: a pilot study in three nutritionally vulnerable Sri Lankan districts. PG - 400 LID - 10.1186/s13104-025-07489-5 [doi] LID - 400 AB - OBJECTIVE: Child malnutrition remains a critical public health challenge in Sri Lanka and is exacerbated by socioeconomic disparities and gaps in community-based educational interventions. This mixed-methods study evaluated the effectiveness of a structured educational program delivered through mothers' support groups on maternal knowledge, attitudes, and practices related to child nutrition and well-being. This study was conducted across three districts (Nuwara Eliya, Trincomalee, and Puttalam), and the quasi-experimental design included pre- and postintervention surveys (n = 208) and focus group discussions with the mothers' support group members. A three-day interactive intervention covered nutrition-related topics, with knowledge, attitudes, and practices assessed via validated questionnaires and thematic analysis of qualitative data. RESULTS: The quantitative results revealed slight non-statistically significant improvements in knowledge (10.77 +/- 2.18-11.04 +/- 2.38, p = 0.064), attitudes (29.12 +/- 4.06-29.70 +/- 3.85, p = 0.095), and practices (19.59 +/- 3.48-20.46 +/- 3.09, p = 0.051). The qualitative findings were more promising, revealing enhanced awareness of balanced diets, strengthened peer networks, and improved childcare practices. Key barriers include financial constraints, logistical challenges, and initial resistance, which can be mitigated through community engagement and multisectoral collaboration. This study demonstrates the potential of mothers' support group-led interventions to foster incremental behavioral changes and social cohesion, despite its limited, statistically significant findings. Scaling such programs requires addressing structural barriers, integrating sustained reinforcement, and leveraging partnerships with local stakeholders. These findings advocate for future research on sustainable, equity-focused nutrition interventions on a much larger scale. CI - (c) 2025. The Author(s). FAU - Wijesinghe, Millawage Supun Dilara AU - Wijesinghe MSD AD - Health Promotion Bureau, No.02, Kynsey Road, Colombo 10, Colombo, Sri Lanka. FAU - Nissanka, Nissanka Achchi Kankanamalage Ayoma Iroshanee AU - Nissanka NAKAI AD - Health Promotion Bureau, No.02, Kynsey Road, Colombo 10, Colombo, Sri Lanka. FAU - Dissanayake, Gayani Sandeepika AU - Dissanayake GS AD - Health Promotion Bureau, No.02, Kynsey Road, Colombo 10, Colombo, Sri Lanka. FAU - Karawita, Upeksha Gayani AU - Karawita UG AD - Health Promotion Bureau, No.02, Kynsey Road, Colombo 10, Colombo, Sri Lanka. FAU - Gunawardana, Balangoda Muhamdiramlage Indika AU - Gunawardana BMI AD - Health Promotion Bureau, No.02, Kynsey Road, Colombo 10, Colombo, Sri Lanka. FAU - Weerasinghe, Weerasinghe Mudiyanselage Prasad Chathuranga AU - Weerasinghe WMPC AD - Health Promotion Bureau, No.02, Kynsey Road, Colombo 10, Colombo, Sri Lanka. FAU - Rathnayaka, Rathnayaka Mudiyanselage Madushani Shiyamala AU - Rathnayaka RMMS AD - Health Promotion Bureau, No.02, Kynsey Road, Colombo 10, Colombo, Sri Lanka. FAU - Mahagamage, Kanchana Lanka Kumari AU - Mahagamage KLK AD - Health Promotion Bureau, No.02, Kynsey Road, Colombo 10, Colombo, Sri Lanka. FAU - Sandamali, Rajapaksha Pathirage Manjula AU - Sandamali RPM AD - ChildFund Sri Lanka, Colombo, Sri Lanka. FAU - Thavaseelan, Rajan AU - Thavaseelan R AD - ChildFund Sri Lanka, Colombo, Sri Lanka. FAU - Batuwanthudawe, Ranjith AU - Batuwanthudawe R AD - Health Promotion Bureau, No.02, Kynsey Road, Colombo 10, Colombo, Sri Lanka. FAU - Alagiyawanna, A M A A P AU - Alagiyawanna AMAAP AD - Health Promotion Bureau, No.02, Kynsey Road, Colombo 10, Colombo, Sri Lanka. LA - eng PT - Journal Article DEP - 20250930 PL - England TA - BMC Res Notes JT - BMC research notes JID - 101462768 SB - IM MH - Humans MH - Sri Lanka MH - *Health Knowledge, Attitudes, Practice MH - Pilot Projects MH - Female MH - Adult MH - *Mothers/education/psychology MH - *Health Education/methods MH - Child, Preschool MH - Male MH - Focus Groups MH - *Child Nutrition Disorders/prevention & control MH - Infant MH - *Child Nutritional Physiological Phenomena MH - Child PMC - PMC12487414 OTO - NOTNLM OT - Accident prevention OT - Child nutrition sciences OT - Community-Based participatory research OT - Maternal behavior OT - Nutritional status OT - Peer group COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Ethics Review Committee of the Postgraduate Institute of Medicine at the University of Colombo (ERC/PGIM/2023/126). Written informed consent was obtained from all participants, confidentiality was maintained, and no incentives were offered. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/10/01 06:29 MHDA- 2025/10/01 06:30 PMCR- 2025/09/30 CRDT- 2025/10/01 01:46 PHST- 2025/02/19 00:00 [received] PHST- 2025/09/02 00:00 [accepted] PHST- 2025/10/01 06:30 [medline] PHST- 2025/10/01 06:29 [pubmed] PHST- 2025/10/01 01:46 [entrez] PHST- 2025/09/30 00:00 [pmc-release] AID - 10.1186/s13104-025-07489-5 [pii] AID - 7489 [pii] AID - 10.1186/s13104-025-07489-5 [doi] PST - epublish SO - BMC Res Notes. 2025 Sep 30;18(1):400. doi: 10.1186/s13104-025-07489-5. PMID- 41029780 OWN - NLM STAT- MEDLINE DCOM- 20251001 LR - 20260328 IS - 2072-1315 (Electronic) IS - 1606-0997 (Print) IS - 1606-0997 (Linking) VI - 44 IP - 1 DP - 2025 Sep 30 TI - Development and validation of the physical literacy scale for young and middle-aged patients with hypertension. PG - 338 LID - 10.1186/s41043-025-01027-6 [doi] LID - 338 AB - BACKGROUND: In recent years, the significance of physical literacy in enhancing the well-being of patients with hypertension has gained increasing recognition. Physical literacy, defined as the motivation, confidence, physical competence, and knowledge and understanding necessary to engage in physical activities, plays a crucial role in promoting a healthy lifestyle. However, most existing studies have focused on the general population or specific subgroups, such as children, adolescents, and older adults, with limited attention to the unique needs of young and middle-aged patients with hypertension. OBJECTIVES: The study aimed to develop and validate the physical literacy scale for young and middle-aged patients with hypertension (PLS-YMPH). We investigated the reliability and validity of this scale to evaluate its quality, providing a valid tool for assessing physical literacy in this specific group. METHODS: Initial items were developed through a literature review and face-to-face interviews. The item pool was modified based on the results of the two-round Delphi method. After forming the initial draft of the PLS-YMPH, items were screened using the critical ratio method, correlation coefficient method, Cronbach's alpha coefficient method, and exploratory factor analysis. Finally, reliability and validity tests were conducted. The content validity, construct validity, discriminant validity, as well as content reliability, split-half reliability, and test-retest reliability of the scale were calculated. RESULTS: The developed scale consists of 4 dimensions and 18 items. The Cronbach's alpha coefficient for the overall scale was 0.943, with individual dimensions ranging from 0.917 to 0.946. The split-half reliability coefficient was 0.833, and the dimensions ranged from 0.919 to 0.947. The test-retest reliability coefficient was 0.854, with dimensions ranging from 0.805 to 0.959. The S-CVI/Ave for the scale was 0.918, and the values for each dimension were 0.925, 0.906, 0.896, and 0.948, all exceeding 0.80. CONCLUSIONS: The developed PLS-YMPH demonstrates good reliability and validity. It provides a valuable tool for assessing the physical literacy of this specific patient group, laying the groundwork for further research in this area. CI - (c) 2025. The Author(s). FAU - Ma, Guiyue AU - Ma G AD - School of Nursing, Anhui University of Chinese Medicine, Hefei, Anhui, China. AD - Key Laboratory of Geriatric Nursing and Health, Anhui University of Chinese Medicine, Hefei, Anhui, China. FAU - Ma, Xiaoqin AU - Ma X AD - School of Nursing, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. 1069664017@qq.com. LA - eng GR - KJ2021A0581/The Natural Science Research Key Project of Education Department of Anhui Provincial Government, China/ GR - 2021xjjy_yb08/The School-level Teaching and Research Project of Anhui University of Chinese Medicine/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250930 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 SB - IM MH - Humans MH - Reproducibility of Results MH - *Hypertension/psychology MH - Female MH - Male MH - Middle Aged MH - *Health Literacy MH - Adult MH - Surveys and Questionnaires/standards MH - *Exercise MH - Psychometrics MH - Young Adult MH - Factor Analysis, Statistical PMC - PMC12486499 OTO - NOTNLM OT - Hypertension OT - Measurement tools OT - Physical literacy OT - Validation OT - Young and middle-aged COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Zhejiang Chinese Medical University (Approval No. 20230922-3). The investigation conforms to the Declaration of Helsinki. Every participants were volunteered for this investigation. Informed consent was obtained from all the participants. The participants read and agreed to the informed consent before starting to fill in the questionnaire. Consent for publication: All authors have reviewed and agreed to the content of this submission. We grant the journal the right to publish this work if it is accepted. Competing interests: The authors declare no competing interests. EDAT- 2025/10/01 06:30 MHDA- 2025/10/01 06:31 PMCR- 2025/09/30 CRDT- 2025/10/01 01:42 PHST- 2025/01/20 00:00 [received] PHST- 2025/07/21 00:00 [accepted] PHST- 2025/10/01 06:31 [medline] PHST- 2025/10/01 06:30 [pubmed] PHST- 2025/10/01 01:42 [entrez] PHST- 2025/09/30 00:00 [pmc-release] AID - 10.1186/s41043-025-01027-6 [pii] AID - 1027 [pii] AID - 10.1186/s41043-025-01027-6 [doi] PST - epublish SO - J Health Popul Nutr. 2025 Sep 30;44(1):338. doi: 10.1186/s41043-025-01027-6. PMID- 41027782 OWN - NLM STAT- MEDLINE DCOM- 20251105 LR - 20251105 IS - 1878-4046 (Electronic) IS - 1076-6332 (Linking) VI - 32 IP - 11 DP - 2025 Nov TI - Influencing Factors and Nomogram Model Construction of Cancer-related Fatigue in Primary Liver Cancer Patients Post-TACE Treatment. PG - 6570-6578 LID - S1076-6332(25)00713-5 [pii] LID - 10.1016/j.acra.2025.07.043 [doi] AB - RATIONALE AND OBJECTIVES: Cancer-related fatigue (CRF) is a common and persistent symptom in primary liver cancer patients undergoing transarterial chemoembolization (TACE), significantly impacting their quality of life and treatment adherence. Despite its multifactorial origins, including physiological, psychological, and treatment-related factors, effective tools for predicting CRF risk are lacking. This study aims to identify key predictors of post-TACE CRF and develop a nomogram to quantify individual risk. METHODS: This study included 202 primary liver cancer patients treated with TACE between 2020 and 2023. The dataset was randomly divided into a training set (70%, n = 141) and a validation set (30%, n = 61). Collected variables encompassed demographic data (age, gender, BMI), disease characteristics (tumor stage, size, liver function), treatment details (TACE sessions, chemotherapeutics, embolic agents), and post-procedural psychological assessments (anxiety, depression scores). Significant predictors of CRF were identified using univariate Logistic regression on the training set and incorporated into a multivariate Logistic model to construct a nomogram. The model's performance was evaluated via Harrell's C-index, AUC, and calibration curves on both the training and validation sets. Internal validation was further conducted using Bootstrap resampling. RESULTS: Tumor size (OR = 1.65, 95% CI: 1.32-2.15, P < 0.001), number of TACE sessions (OR = 1.82, 95% CI: 1.45-2.37, P < 0.001), anxiety score (OR = 1.45, 95% CI: 1.20-1.75, P < 0.001), and Child-Pugh class (OR = 2.35, 95% CI: 1.75-3.19, P < 0.001) were independent predictors of CRF. The nomogram demonstrated a C-index of 0.85 (95% CI: 0.80-0.90) and an AUC of 0.88 (95% CI: 0.83-0.93) in the training set, with a C-index of 0.83 (95% CI: 0.77-0.89) and an AUC of 0.86 (95% CI: 0.81-0.91) in the validation set. Calibration curves indicated good agreement between predicted and observed CRF outcomes, with Brier Scores of 0.1252 and 0.1292 in the training and validation sets, respectively. CONCLUSION: This study developed a robust nomogram for predicting CRF in primary liver cancer patients undergoing TACE, providing a valuable tool for personalized risk assessment and proactive management strategies. CI - Copyright (c) 2025. Published by Elsevier Inc. FAU - Zhang, Ji AU - Zhang J AD - Interventlonal Ward of Diagnostic Radiology Department, The 900 Hospital of the Joint Service Support Force of the People's Liberation Army, Fuzhou, China (J.Z.). FAU - Zu, Jiaoli AU - Zu J AD - The Second Department of Cadre Ward, The 900 Hospital of the Joint Service Support Force of the People's Liberation Army, Fuzhou, China (J.Z.). Electronic address: 785615154@qq.com. LA - eng PT - Journal Article DEP - 20250929 PL - United States TA - Acad Radiol JT - Academic radiology JID - 9440159 SB - IM MH - Humans MH - *Nomograms MH - *Fatigue/etiology MH - Male MH - Female MH - *Chemoembolization, Therapeutic/adverse effects MH - *Liver Neoplasms/therapy/complications MH - Middle Aged MH - Aged MH - Risk Factors MH - Quality of Life MH - Retrospective Studies OTO - NOTNLM OT - Cancer-related fatigue OT - Nomogram OT - Primary liver cancer OT - Risk prediction OT - Transarterial chemoembolization COIS- Declaration of Competing Interest The authors declare that they have no competing interests related to the manuscript titled "Development and Validation of a Nomogram for Predicting Cancer-Related Fatigue in Primary Liver Cancer Patients Undergoing Transarterial Chemoembolization." No financial or personal relationships have influenced the content of this manuscript. EDAT- 2025/10/01 00:28 MHDA- 2025/11/06 00:27 CRDT- 2025/09/30 21:59 PHST- 2025/04/01 00:00 [received] PHST- 2025/07/16 00:00 [revised] PHST- 2025/07/20 00:00 [accepted] PHST- 2025/11/06 00:27 [medline] PHST- 2025/10/01 00:28 [pubmed] PHST- 2025/09/30 21:59 [entrez] AID - S1076-6332(25)00713-5 [pii] AID - 10.1016/j.acra.2025.07.043 [doi] PST - ppublish SO - Acad Radiol. 2025 Nov;32(11):6570-6578. doi: 10.1016/j.acra.2025.07.043. Epub 2025 Sep 29. PMID- 41027030 OWN - NLM STAT- MEDLINE DCOM- 20250930 LR - 20260810 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 9 DP - 2025 Sep 30 TI - The Validation and Accuracy of Wearable Heart Rate Trackers in Children With Heart Disease: Prospective Cohort Study. PG - e70835 LID - 10.2196/70835 [doi] LID - e70835 AB - BACKGROUND: Wearables are increasingly used in pediatric cardiology for heart rate (HR) monitoring due to advantages over traditional HR monitoring, such as prolonged monitoring time, increased patient comfort, and ease of use. However, their validation in this population is limited. OBJECTIVE: The objective of this paper was to assess HR accuracy and validity from 2 wearables, the Corsano CardioWatch bracelet and the Hexoskin smart shirt, in children attending the pediatric cardiology outpatient clinic, exploring factors that influence accuracy, the Hexoskin shirt's arrhythmia detection efficacy, and patient satisfaction. METHODS: Children with an indication for 24-hour Holter monitoring were equipped with a 24-hour Holter electrocardiogram (ECG; gold standard), together with both wearables. HR accuracy was defined as the percentage of HRs within 10% of Holter values, and agreement was assessed using Bland-Altman analysis. Subgroup analyses were conducted based on BMI, age, and time of wearing, among other factors. The association between accelerometry (expressed in gravitational units, g) and HR accuracy was analyzed to assess the impact of bodily movement on measurement accuracy. A blinded pediatric cardiologist analyzed Hexoskin shirt data for rhythm classification. Patient satisfaction was measured using a 5-point Likert scale questionnaire. RESULTS: A total of 31 participants (mean age 13.2, SD 3.6 y; n=14, 45% female) and 36 participants (mean age 13.3, SD 3.9 y) were included for the CardioWatch and Hexoskin measurements, respectively. Mean accuracy was 84.8% (SD 8.7%) for the CardioWatch and 87.4% (SD 11%) for the Hexoskin shirt. Hexoskin shirt accuracy was notably higher in the first 12 hours (94.9%, SD 7.4%) compared to the latter 12 (80%, SD 16.7%; P<.001). Higher accuracy was observed at lower HRs (low vs high HR: CardioWatch: 90.9%, SD 9.3% vs 79%, SD 10.6%; P<.001 and Hexoskin shirt: 90.6%, SD 14% vs 84.5, SD 11.8%; P<.001). Both wearables demonstrated good agreement in their HR measurement with Holter readings (CardioWatch bias: -1.4 beats per minute [BPM]; 95% limits of agreement [LoA] -18.8 to 16.0. Hexoskin shirt bias: -1.1 BPM; 95% LoA -19.5 to 17.4). HR measurement accuracy declined during more intense bodily movements. Correct classification of the Hexoskin's shirt rhythm recordings was achieved in 86% (31/36) of cases. Patient satisfaction scores were significantly higher for both the CardioWatch (median 3.8, range 3.5-4.3; P<.001) and Hexoskin shirt (median 3.7, range 3.0-4.0; P<.001) compared to the Holter (median 2.6, range 2.1-3.2). CONCLUSIONS: The Corsano CardioWatch and Hexoskin shirt demonstrate good accuracy in pediatric HR monitoring and provide higher patient comfort than conventional monitoring. Both wearables show good agreement in relation to the gold standard device. However, measurement accuracy declines with increasing bodily movement and higher heart rates. More research is needed to explore the underlying causes for these inaccuracies and how to counteract them. The Hexoskin shirt also shows potential in arrhythmia detection. While further development is warranted, these wearables show promise in enhancing diagnostics, therapeutic monitoring, and patient safety in pediatric cardiology. CI - (c) Hidde J Hardon, Yara N Van Kerkhof, Beatrijs Bartelds, Janneke A E Kammeraad, Arend W Van Deutekom. Originally published in JMIR Formative Research (https://formative.jmir.org). FAU - Hardon, Hidde J AU - Hardon HJ AUID- ORCID: 0009-0008-0411-1863 AD - Division of Pediatric Cardiology, Department of Pediatrics, Erasmus MC, Dr Molewaterplein 40, Rotterdam, 3015GD, The Netherlands, 31 10 704 0704. FAU - Van Kerkhof, Yara N AU - Van Kerkhof YN AUID- ORCID: 0009-0004-0521-5796 AD - Division of Pediatric Cardiology, Department of Pediatrics, Erasmus MC, Dr Molewaterplein 40, Rotterdam, 3015GD, The Netherlands, 31 10 704 0704. FAU - Bartelds, Beatrijs AU - Bartelds B AUID- ORCID: 0000-0003-3151-2474 AD - Division of Pediatric Cardiology, Department of Pediatrics, Erasmus MC, Dr Molewaterplein 40, Rotterdam, 3015GD, The Netherlands, 31 10 704 0704. FAU - Kammeraad, Janneke A E AU - Kammeraad JAE AUID- ORCID: 0000-0002-1556-9422 AD - Division of Pediatric Cardiology, Department of Pediatrics, Erasmus MC, Dr Molewaterplein 40, Rotterdam, 3015GD, The Netherlands, 31 10 704 0704. FAU - Van Deutekom, Arend W AU - Van Deutekom AW AUID- ORCID: 0000-0002-8284-8288 AD - Division of Pediatric Cardiology, Department of Pediatrics, Erasmus MC, Dr Molewaterplein 40, Rotterdam, 3015GD, The Netherlands, 31 10 704 0704. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250930 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - Female MH - Male MH - Child MH - Prospective Studies MH - *Heart Rate/physiology MH - *Electrocardiography, Ambulatory/instrumentation/methods MH - *Wearable Electronic Devices/standards/statistics & numerical data MH - *Heart Diseases/physiopathology/diagnosis MH - Adolescent MH - Reproducibility of Results MH - Patient Satisfaction MH - Child, Preschool PMC - PMC12483337 OTO - NOTNLM OT - ECG OT - electrocardiogram OT - heart rate monitoring OT - patient satisfaction OT - validation OT - wearable technology COIS- Conflicts of Interest: None declared. EDAT- 2025/09/30 18:28 MHDA- 2025/09/30 18:29 PMCR- 2025/09/30 CRDT- 2025/09/30 17:02 PHST- 2025/01/03 00:00 [received] PHST- 2025/06/13 00:00 [revised] PHST- 2025/06/14 00:00 [accepted] PHST- 2025/09/30 18:29 [medline] PHST- 2025/09/30 18:28 [pubmed] PHST- 2025/09/30 17:02 [entrez] PHST- 2025/09/30 00:00 [pmc-release] AID - v9i1e70835 [pii] AID - 70835 [pii] AID - 10.2196/70835 [doi] PST - epublish SO - JMIR Form Res. 2025 Sep 30;9:e70835. doi: 10.2196/70835. PMID- 41023500 OWN - NLM STAT- MEDLINE DCOM- 20251009 LR - 20261010 IS - 1573-7373 (Electronic) IS - 0167-594X (Linking) VI - 175 IP - 3 DP - 2025 Dec TI - Prognostic value of temporal muscle thickness in pediatric medulloblastoma patients aged 3-12 years. PG - 1235-1246 LID - 10.1007/s11060-025-05229-0 [doi] AB - PURPOSE: This retrospective, multicenter cohort study aimed to investigate the prognostic significance of temporal muscle thickness (TMT) in medulloblastoma (MB) patients. METHODS: Preoperative cranial MRI was used to measure TMT. Patients were divided into training and test cohorts. An optimal TMT cutoff for progression-free survival (PFS) and overall survival (OS) was established. RESULTS: Among the 303 enrolled MB patients, TMT was found to be associated with prognosis in the 230 patients aged 3-12 years. TMT demonstrated positive correlations with age and body mass index, while inverse associations were observed with the presence of hydrocephalus and metastasis. A TMT cutoff value of 6.115 mm was established in the training cohort, which served as a significant threshold for both PFS and OS. The 5-year PFS rates were (38.0 +/- 11.5) % (low mean-TMT group) versus (88.3 +/- 3.2) % (high mean-TMT group), and OS rates were (57.2 +/- 8.7) % versus (96.5 +/- 1.7) %, respectively. The multivariate Cox regression revealed significantly better PFS (hazard ratio (HR) = 0.165; 95% confidence interval (CI): 0.064-0.427; P < 0.001) and OS (HR = 0.064; 95% CI: 0.020-0.207; P < 0.001) in patients above versus below this cutoff. These findings were validated in test cohort and two independent validation cohorts. CONCLUSION: MRI-measured TMT is a potential prognostic indicator for MB patients aged 3-12 years, and may help guide risk stratification and treatment planning. To validate its clinical applicability, large-sample prospective researches remain essential. CI - (c) 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - An, Xu AU - An X AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 Nansihuanxilu, Fengtai District, Beijing, China. AD - Department of Critical Care Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. FAU - Wang, Junhua AU - Wang J AD - Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing, China. FAU - Yuan, Jingzhe AU - Yuan J AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 Nansihuanxilu, Fengtai District, Beijing, China. FAU - Zhou, Xuan AU - Zhou X AD - Department of Anesthesiology, Tsinghua University Yuquan Hospital, Beijing, China. FAU - Liu, Xiaozhu AU - Liu X AD - Department of Critical Care Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. FAU - Sun, Xiaoyan AU - Sun X AD - The institute of artificial intelligence, Hefei Comprehensive National Science Center, Anhui, China. AD - University of Science and Technology of China, Anhui, China. FAU - Gong, Jian AU - Gong J AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 Nansihuanxilu, Fengtai District, Beijing, China. AD - The institute of artificial intelligence, Hefei Comprehensive National Science Center, Anhui, China. FAU - Wu, Qingnan AU - Wu Q AD - Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Molecular Oncology, Peking University Cancer Hospital & Institute, Beijing, China. 1049533997@qq.com. FAU - Ou, Yunwei AU - Ou Y AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 Nansihuanxilu, Fengtai District, Beijing, China. ouyangyunwei@sina.cn. AD - Beijing Neurosurgical Institute, Capital Medical University, Beijing, China. ouyangyunwei@sina.cn. LA - eng GR - 82327806/The National Natural Science Foundation of China/ GR - 21KT013/The Institute of Artificial Intelligence, Hefei Comprehensive National Science Center/ PT - Journal Article PT - Multicenter Study DEP - 20250929 PL - United States TA - J Neurooncol JT - Journal of neuro-oncology JID - 8309335 SB - IM MH - Humans MH - Child, Preschool MH - Child MH - Female MH - Male MH - *Medulloblastoma/pathology/mortality/diagnostic imaging MH - Prognosis MH - *Cerebellar Neoplasms/pathology/mortality/diagnostic imaging MH - Magnetic Resonance Imaging MH - Retrospective Studies MH - *Temporal Muscle/pathology/diagnostic imaging MH - Follow-Up Studies MH - Survival Rate OTO - NOTNLM OT - Medulloblastoma OT - Overall survival OT - Progression-free survival OT - Sarcopenia OT - Temporal muscle thickness COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Beijing Tiantan Hospital, Capital Medical University (Date May 17, 2022/No. KY2022-067-01). The Ethical Review Committee of Tsinghua University Yuquan Hospital approved the study design of the external test cohorts (Date March 7, 2023/ No. 2023029). Consent to participate: All patients or legal guardians provided written informed consent to participate in this study. Consent for publication: All patients or legal guardians provided written informed consent to publish their data. EDAT- 2025/09/30 06:38 MHDA- 2025/10/09 18:28 CRDT- 2025/09/30 00:18 PHST- 2025/07/29 00:00 [received] PHST- 2025/08/28 00:00 [accepted] PHST- 2025/10/09 18:28 [medline] PHST- 2025/09/30 06:38 [pubmed] PHST- 2025/09/30 00:18 [entrez] AID - 10.1007/s11060-025-05229-0 [pii] AID - 10.1007/s11060-025-05229-0 [doi] PST - ppublish SO - J Neurooncol. 2025 Dec;175(3):1235-1246. doi: 10.1007/s11060-025-05229-0. Epub 2025 Sep 29. PMID- 41022654 OWN - NLM STAT- MEDLINE DCOM- 20250929 LR - 20260127 IS - 2224-7041 (Electronic) IS - 2078-9947 (Linking) VI - 35 IP - 3 DP - 2025 Sep TI - Associations between eating disorder symptoms and latent bipolarity in patients with major depressive disorder. PG - 161-166 LID - 10.12809/eaap2528 [doi] AB - OBJECTIVES: To determine the correlations between eating disorder symptoms and clinical and psychometric characteristics of major depressive disorder (MDD). METHODS: Patients aged 18 to 59 years diagnosed with MDD, regardless of the stage (exacerbation or remission), were recruited from both outpatient and inpatient settings across seven centres in Russia. The MDD diagnosis of each patient was confirmed using the Mini International Neuropsychiatric Interview. Depression severity was assessed using the clinician-administered Montgomery-Asberg Depression Rating Scale. Disordered eating behaviours were assessed using the 26-item Eating Attitudes Test (EAT-26). Severity of anhedonia was assessed using the Snaith-Hamilton Pleasure Scale. Symptoms of hypomania were identified using the Hypomania Checklist. Suicide risk was assessed using the Columbia Suicide Severity Rating Scale. Symptoms of depression and anxiety were assessed using the Hospital Anxiety and Depression Scale. State and trait anxiety levels were assessed using the State-Trait Anxiety Inventory. RESULTS: In total, 216 women and 122 men aged 18 to 59 years with a diagnosis of MDD were included in analysis. Higher EAT-26 scores were associated with longer duration of the longest depressive episode, an earlier age of MDD onset, and a tendency towards hyperphagia during depressive episodes. EAT-26 scores were positively correlated with the Hypomania Checklist scores (rho = 0.346, p < 0.001), the presence of suicidal ideations during the previous month (rho = 0.146, p = 0.008), and the trait anxiety score (rho = 0.198, p = 0.003) of the State-Trait Anxiety Inventory. CONCLUSION: Patients with MDD who exhibited more pronounced disordered eating behaviours also had an earlier age of onset, a longer duration of the longest depressive episode, and higher Hypomania Checklist scores. These clinical markers are more characteristic of bipolar disorder, suggesting latent bipolarity or an increased risk of progression to bipolar disorder. FAU - Yakovleva, Y V AU - Yakovleva YV AD - Department of Social Neuropsychiatry, VM Bekhterev National Medical Research Center for Psychiatry and Neurology, Saint Petersburg, Russia. FAU - Kasyanov, E D AU - Kasyanov ED AD - Department of Social Neuropsychiatry, VM Bekhterev National Medical Research Center for Psychiatry and Neurology, Saint Petersburg, Russia. FAU - Rukavishnikov, G V AU - Rukavishnikov GV AD - Department of Social Neuropsychiatry, VM Bekhterev National Medical Research Center for Psychiatry and Neurology, Saint Petersburg, Russia. FAU - Kibitov, A O AU - Kibitov AO AD - Department of Genomics of Mental Disorders, VM Bekhterev National Medical Research Center for Psychiatry and Neurology, Saint Petersburg, Russia. FAU - Mazo, G E AU - Mazo GE AD - Innovative Scientific Development, Translational Psychiatry Institute, VM Bekhterev National Medical Research Center for Psychiatry and Neurology, Saint Petersburg, Russia. LA - eng PT - Journal Article PL - China TA - East Asian Arch Psychiatry JT - East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan JID - 101536416 SB - IM MH - Humans MH - Adult MH - Female MH - Male MH - *Major Depressive Disorder/psychology/complications/epidemiology MH - Middle Aged MH - *Feeding and Eating Disorders/psychology/epidemiology/complications MH - Young Adult MH - Adolescent MH - *Bipolar Disorder/psychology/epidemiology MH - Psychiatric Status Rating Scales MH - Severity of Illness Index MH - Russia/epidemiology MH - Anxiety/psychology MH - Psychometrics OTO - NOTNLM OT - Bipolar disorder OT - Depressive disorder, major OT - Feeding and eating disorders COIS- All authors have disclosed no conflicts of interest. EDAT- 2025/09/30 05:17 MHDA- 2025/09/30 05:18 CRDT- 2025/09/29 22:42 PHST- 2025/09/30 05:18 [medline] PHST- 2025/09/30 05:17 [pubmed] PHST- 2025/09/29 22:42 [entrez] AID - 10.12809/eaap2528 [doi] PST - ppublish SO - East Asian Arch Psychiatry. 2025 Sep;35(3):161-166. doi: 10.12809/eaap2528. PMID- 41022129 OWN - NLM STAT- MEDLINE DCOM- 20260424 LR - 20260519 IS - 1098-8785 (Electronic) IS - 0735-1631 (Linking) VI - 43 IP - 7 DP - 2026 May TI - Nutrition Pattern and Adverse Pregnancy Outcomes in Nulliparous Individuals: A Cluster Analysis. PG - 955-962 LID - 10.1055/a-2712-5518 [doi] AB - OBJECTIVE: This study aimed to develop a k-means clustering algorithm to identify distinct food intake patterns through cluster analysis. STUDY DESIGN: This was a secondary analysis of the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b), including nulliparous individuals with singleton pregnancies. Dietary intake data from the 3 months preceding pregnancy were collected using a validated questionnaire. The primary outcome was a composite measure including preterm birth, stillbirth, preeclampsia, eclampsia, gestational diabetes, and small for gestational age. Clusters were formed using a k-means clustering algorithm with Euclidean distance, based on 335 dietary variables. The association between dietary clusters and adverse pregnancy outcomes (APOs) was assessed. Relative risks with 95% confidence intervals (95% CIs) were calculated using modified Poisson regression, adjusting for predefined confounders. A random forest model was also employed to identify features predictive of cluster allocation. RESULTS: The analysis included 7,599 participants, distributed across three clusters: Cluster 1 (n = 4,243, 55.8%), Cluster 2 (n = 2,768, 36.4%), and Cluster 3 (n = 588, 7.7%). Cluster 2, which serves as the referent cluster, is characterized by a higher intake of vitamin E as alpha-tocopherol, vitamin A retinol activity equivalents, vegetables, and fruits, aligning most closely with a healthy diet pattern. Compared with Cluster 2, Cluster 1, characterized by a lower intake of the same nutrients, did not show a significant association with increased odds of APOs (22.7 vs. 25.4%; adjusted relative risk [aRR], 1.07 [95% CI: 0.98-1.18]). In contrast, Cluster 3, characterized by higher intake of trans fats, dietary polyunsaturated fatty acids 20:4, red meat, and sugary beverages, was significantly associated with APOs compared with Cluster 2 (31.0 vs. 22.7%; aRR, 1.19 [95% CI: 1.01-1.39]). CONCLUSION: A dietary pattern characterized by a high intake of trans fats, polyunsaturated fatty acids, red meat, and sugary beverages is significantly associated with an increased risk of APOs. KEY POINTS: . Diets high in trans fats, polyunsaturated fatty acids, red meat, and sugary beverages are associated with increased APOs.. . Diets rich in vitamin E, vitamin A, vegetables, and green salads are linked to a lower risk of these outcomes.. . This study underscores the significant role of nutrition in influencing APOs.. CI - Thieme. All rights reserved. FAU - Kawakita, Tetsuya AU - Kawakita T AUID- ORCID: 0000-0003-2438-1699 AD - Department of Obstetrics and Gynecology, Macon and Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, United States. FAU - Diab, Yara H AU - Diab YH AD - Department of Obstetrics and Gynecology, Macon and Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, United States. FAU - Onishi, Kazuma AU - Onishi K AUID- ORCID: 0000-0002-2054-4684 AD - Department of Obstetrics and Gynecology, Macon and Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, United States. FAU - Saade, George AU - Saade G AD - Department of Obstetrics and Gynecology, Macon and Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, United States. LA - eng PT - Journal Article DEP - 20250929 PL - United States TA - Am J Perinatol JT - American journal of perinatology JID - 8405212 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Cluster Analysis MH - Adult MH - *Pregnancy Outcome/epidemiology MH - *Diet MH - Parity MH - Infant, Newborn MH - *Pregnancy Complications/epidemiology MH - Premature Birth/epidemiology MH - Algorithms MH - Stillbirth/epidemiology MH - Infant, Small for Gestational Age MH - Young Adult COIS- The authors declare that they have no conflict of interest. EDAT- 2025/09/30 05:16 MHDA- 2026/04/25 00:34 CRDT- 2025/09/29 19:13 PHST- 2026/04/25 00:34 [medline] PHST- 2025/09/30 05:16 [pubmed] PHST- 2025/09/29 19:13 [entrez] AID - 10.1055/a-2712-5518 [doi] PST - ppublish SO - Am J Perinatol. 2026 May;43(7):955-962. doi: 10.1055/a-2712-5518. Epub 2025 Sep 29. PMID- 41021548 OWN - NLM STAT- MEDLINE DCOM- 20250929 LR - 20260930 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 9 DP - 2025 TI - Rationale and protocol for an observational study of in vivo stress experiences and real-time cardiovascular responses among young, black women: The DYNAMIC study. PG - e0330508 LID - 10.1371/journal.pone.0330508 [doi] LID - e0330508 AB - BACKGROUND: Chronic stress is thought to contribute to racial disparities in cardiovascular morbidity and mortality among women. Intervention development has been stalled by complex issues regarding stress measurement as well as the correlation of varying stress experiences with proximal cardiac responses in naturalistic environments. METHODS: The Designing Young Adult Interventions to Address and Mitigate Inequities in Cardiovascular Health (DYNAMIC) Study is an observational study of the stress experiences of young Black women reported in vivo and within naturalistic context. The study will enroll up to 50 participants aged 18 to 39 years old. Participants will undergo a 14-day protocol, including completion of random surveys regarding stressor administered via ecological momentary assessment (EMA) while wearing a 24-hour ambulatory ECG monitoring patch and actigraph watch to capture a continuous feed of physiological responses. Participants will also measure and log wakening and bedtime blood pressure readings using a validated cuff. DISCUSSION: The study addresses ongoing challenges to validity in correlating stress to cardiovascular outcomes. The combination of EMA surveys and continuous physiological monitoring provides rich data regarding stress response, including frequency, duration, and attribution to specific stress stimuli. The primary outcomes of the study are heart rate variability and blood pressure. The secondary outcome of this study is ideal cardiovascular health-an index of measures predicting healthy cardiovascular aging. CONCLUSION: Findings from this study may be used to inform responsive, tailored interventions for young Black women towards the aims of primordial prevention and early intervention to promote cardiovascular health and reduce disparities. CI - Copyright: (c) 2025 Hines et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Hines, Anika L AU - Hines AL AUID- ORCID: 0000-0003-3502-5606 AD - Department of Health Policy, Virginia Commonwealth University, School of Public Health, Richmond, Virginia, United States of America. AD - Division of General Internal Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America. FAU - Sall, Fota AU - Sall F AD - Department of Health Policy, Virginia Commonwealth University, School of Public Health, Richmond, Virginia, United States of America. FAU - Utsey, Shawn AU - Utsey S AD - Department of Psychology, Virginia Commonwealth University, College of Humanities and Sciences, Richmond, Virginia, United States of America. FAU - Perera, Robert AU - Perera R AD - Department of Biostatistics, Virginia Commonwealth University, School of Public Health, Richmond, Virginia, United States of America. FAU - Evans, Ron K AU - Evans RK AD - College of Humanities and Sciences, Department of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, Virginia, United States of America. FAU - Cooper, Lisa A AU - Cooper LA AD - Division of General Internal Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America. AD - Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America. FAU - LaRose, Jessica Gokee AU - LaRose JG AD - Department of Social and Behavioral Sciences, Virginia Commonwealth University, School of Public Health, Richmond, Virginia, United States of America. LA - eng PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20250929 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - Adult MH - *Stress, Psychological/physiopathology MH - Young Adult MH - Adolescent MH - *Black or African American/psychology MH - Heart Rate/physiology MH - *Cardiovascular Diseases/physiopathology MH - Blood Pressure/physiology MH - Ecological Momentary Assessment MH - White PMC - PMC12478878 COIS- The authors have declared that no competing interests exist. EDAT- 2025/09/29 22:46 MHDA- 2025/09/29 22:47 PMCR- 2025/09/29 CRDT- 2025/09/29 13:35 PHST- 2025/07/24 00:00 [received] PHST- 2025/07/28 00:00 [accepted] PHST- 2025/09/29 22:47 [medline] PHST- 2025/09/29 22:46 [pubmed] PHST- 2025/09/29 13:35 [entrez] PHST- 2025/09/29 00:00 [pmc-release] AID - PONE-D-25-38288 [pii] AID - 10.1371/journal.pone.0330508 [doi] PST - epublish SO - PLoS One. 2025 Sep 29;20(9):e0330508. doi: 10.1371/journal.pone.0330508. eCollection 2025. PMID- 41019474 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250929 LR - 20251001 IS - 2325-9671 (Print) IS - 2325-9671 (Electronic) IS - 2325-9671 (Linking) VI - 13 IP - 9 DP - 2025 Sep TI - Psychometric Properties of the Arabic Hospital for Special Surgery Pediatric Functional Activity Brief Scale (Ar-HSS-Pedi-FABS) Among Saudi Children and Adolescents: A Validation Study. PG - 23259671251376536 LID - 10.1177/23259671251376536 [doi] LID - 23259671251376536 AB - BACKGROUND: Children and adolescents' participation in organized sports is widespread, resulting in significant sports-related injuries. The Hospital for Special Surgery Pediatric Functional Activity Brief Scale (HSS Pedi-FABS) assesses activity levels in children and adolescents involved in sports. Current Arabic-language pediatric orthopaedic rating scales often overlook active children or are lengthy and culturally biased, limiting their effectiveness. PURPOSE: To translate, culturally adapt, and validate the HSS Pedi-FABS for Arabic-speaking populations. STUDY DESIGN: Cohort study (Diagnosis); Level of evidence 3. METHODS: This study was conducted from March to June 2024 at King Saud University Medical City in Riyadh, Saudi Arabia, and included participants aged 8 to 21 years who were fluent in Arabic and participated in organized sports and physical activity. The HSS Pedi-FABS was translated and validated through a multistep process involving forward and backward translations by certified translators, expert review, and face and content validity testing with content experts. Participants completed a survey with demographic questions, the Arabic-adapted HSS Pedi-FABS, and the Pediatric Activity Questionnaire for Older Children (PAQ-C). Reliability was assessed by internal consistency and test-retest reliability assessments and validity through both convergent and discriminant validity analyses. RESULTS: A total of 150 participants aged 8 to 21 years were included. The Arabic HSS Pedi-FABS (Ar-Pedi-FABS) demonstrated acceptable internal consistency (Cronbach alpha, .79) and substantial agreement on test-retest reliability (intraclass correlation coefficient, 0.78). Convergent validity with the PAQ-C demonstrated moderate positive correlation (r = 0.60; P < .001), with Bland-Altman analysis indicating mean differences close to zero. Discriminant validity testing revealed that age demonstrated a clinically insignificant negative correlation with Ar-Pedi-FABS and sex was not significantly associated with Ar-Pedi-FABS. CONCLUSION: This study translated, cross-culturally adapted, and validated an Arabic version of the HSS Pedi-FABS, which demonstrated acceptable reliability and validity for assessing activity levels in Arabic-speaking children and adolescents. This development facilitates the assessment of physical activity in a way that respects cultural relevance for Arabic-speaking populations, supporting better communication, tailored interventions, and improved health outcomes. CI - (c) The Author(s) 2025. FAU - Addar, Abdullah AU - Addar A AD - Department of Orthopedic Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia. FAU - AbuDujain, Nasser M AU - AbuDujain NM AUID- ORCID: 0000-0001-5290-1482 AD - Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia. FAU - Alhabib, Fayez A AU - Alhabib FA AD - College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. FAU - Alhumimidi, Abdullah AU - Alhumimidi A AD - College of Medicine, King Saud University, Riyadh, Saudi Arabia. FAU - Alghamdi, Hani A AU - Alghamdi HA AD - Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia. FAU - Alsemairi, Rahaf AU - Alsemairi R AD - College of Languages and Translation, Princess Nourah Bint Abdul Rahman University, Riyadh, Saudi Arabia. FAU - Alabdulkarim, Yasir AU - Alabdulkarim Y AD - Department of Orthopedic Surgery, King Fahad Medical City, Riyadh, Saudi Arabia. FAU - Jones, Ruth H AU - Jones RH AD - Pediatric Orthopedic Surgery Service, Hospital for Special Surgery, New York, New York, USA. FAU - Fabricant, Peter D AU - Fabricant PD AUID- ORCID: 0000-0002-8070-685X AD - Pediatric Orthopedic Surgery Service, Hospital for Special Surgery, New York, New York, USA. LA - eng PT - Journal Article DEP - 20250924 PL - United States TA - Orthop J Sports Med JT - Orthopaedic journal of sports medicine JID - 101620522 PMC - PMC12461062 OTO - NOTNLM OT - HSS Pedi-FABS OT - Saudi Arabia OT - pediatric, activity OT - reliability OT - validity COIS- One or more of the authors has declared the following potential conflict of interest or source of funding: P.D.F. is an associate editor of Clinical Orthopedics and Related Research; is a paid consultant for BICMD, Inc; receives publishing royalties from Springer Nature; and owns stock or stock options in Osso VR. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto. EDAT- 2025/09/29 13:18 MHDA- 2025/09/29 13:19 PMCR- 2025/09/24 CRDT- 2025/09/29 06:56 PHST- 2025/05/13 00:00 [received] PHST- 2025/07/01 00:00 [accepted] PHST- 2025/09/29 13:19 [medline] PHST- 2025/09/29 13:18 [pubmed] PHST- 2025/09/29 06:56 [entrez] PHST- 2025/09/24 00:00 [pmc-release] AID - 10.1177_23259671251376536 [pii] AID - 10.1177/23259671251376536 [doi] PST - epublish SO - Orthop J Sports Med. 2025 Sep 24;13(9):23259671251376536. doi: 10.1177/23259671251376536. eCollection 2025 Sep. PMID- 41017793 OWN - NLM STAT- MEDLINE DCOM- 20250929 LR - 20251001 IS - 1661-8564 (Electronic) IS - 1661-8556 (Print) IS - 1661-8556 (Linking) VI - 70 DP - 2025 TI - Determinants of Life Satisfaction and Mental Wellbeing in the Danish General Population: Shared and Distinct Associations. PG - 1608531 LID - 10.3389/ijph.2025.1608531 [doi] LID - 1608531 AB - OBJECTIVE: To examine the correlation between two wellbeing components: life satisfaction and mental wellbeing and identify key determinants (sociodemographic, health, behavioural, social). METHODS: This cross-sectional study used data from 10,196 adults from the nationally representative Danish National Health Survey 2023. Main outcomes were self-reported life satisfaction measured on a single-item scale from 0-10 and mental wellbeing by the short version of the Warwick-Edinburgh Mental Wellbeing Scale (SWEMWBS). Correlations were examined using Spearman's rho (rho) and Pearson's correlation coefficient (r). Linear regression models estimated associations between key determinants and the outcomes. RESULTS: The two outcomes were strongly correlated, yet remained distinct. Wellbeing scores were similar across sex, age, ethnicity, education, employment, BMI, tobacco, and alcohol use. Scores varied by marital status, financial strain, self-rated health, chronic illness, physical activity, loneliness, stress, anxiety, and depression risk. Associations with pain, sleep quality, social support, and leisure activities were mixed. CONCLUSION: Despite a strong correlation discriminant validity was maintained. Wellbeing outcomes should not be treated as interchangeable, as their associations vary across population groups. CI - Copyright (c) 2025 Rasmussen, Santini, Joshanloo, Petersen and Christensen. FAU - Rasmussen, Mette AU - Rasmussen M AD - National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. FAU - Santini, Ziggi Ivan AU - Santini ZI AD - Copenhagen Research Unit for Recovery, Mental Health Services, Mental Health Centre Amager, Copenhagen, Denmark. FAU - Joshanloo, Mohsen AU - Joshanloo M AD - Department of Psychology, Keimyung University, Daegu, Republic of Korea. FAU - Petersen, Christina Bjork AU - Petersen CB AD - National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. AD - Center for Clinical Research and Prevention, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Christensen, Anne Illemann AU - Christensen AI AD - National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. LA - eng PT - Journal Article DEP - 20250912 PL - Switzerland TA - Int J Public Health JT - International journal of public health JID - 101304551 SB - IM MH - Humans MH - Male MH - Female MH - Denmark/epidemiology MH - *Personal Satisfaction MH - Middle Aged MH - Cross-Sectional Studies MH - Adult MH - *Mental Health/statistics & numerical data MH - Aged MH - Health Surveys MH - Young Adult MH - Sociodemographic Factors MH - Socioeconomic Factors MH - Adolescent MH - Health Status MH - Social Support PMC - PMC12463736 OTO - NOTNLM OT - correlation OT - cross-sectional survey OT - health measures OT - life satisfaction OT - mental wellbeing COIS- The authors declare that they do not have any conflicts of interest. EDAT- 2025/09/29 13:19 MHDA- 2025/09/29 13:20 PMCR- 2025/09/12 CRDT- 2025/09/29 06:35 PHST- 2025/03/21 00:00 [received] PHST- 2025/08/22 00:00 [accepted] PHST- 2025/09/29 13:20 [medline] PHST- 2025/09/29 13:19 [pubmed] PHST- 2025/09/29 06:35 [entrez] PHST- 2025/09/12 00:00 [pmc-release] AID - 1608531 [pii] AID - 10.3389/ijph.2025.1608531 [doi] PST - epublish SO - Int J Public Health. 2025 Sep 12;70:1608531. doi: 10.3389/ijph.2025.1608531. eCollection 2025. PMID- 41017504 OWN - NLM STAT- MEDLINE DCOM- 20260210 LR - 20260922 IS - 1360-0443 (Electronic) IS - 0965-2140 (Print) IS - 0965-2140 (Linking) VI - 121 IP - 3 DP - 2026 Mar TI - Ultra-processed food addiction in a nationally representative sample of older adults in the USA. PG - 510-521 LID - 10.1111/add.70186 [doi] AB - AIMS: Ultra-processed foods (UPFs; industrially produced foods typically containing unnaturally elevated levels of refined carbohydrates and/or added fats) became more widely introduced into the United States (US) food environment in the 1980s and have proliferated since. UPFs have been shown to trigger an addictive-like response. This study examines the prevalence of ultra-processed food addiction (UPFA) in older US adults and its association with various health domains. DESIGN: In July 2022, a cross-sectional online and telephone survey was conducted using the University of Michigan National Poll on Healthy Aging (NPHA). Gender-stratified analyses examined the association between UPFA and perceptions of physical and mental health, and social isolation. Prevalence ratios were calculated, unadjusted and adjusted for age, race/ethnicity, education, and income. SETTING: Nationally representative sample of older adults (aged 50-80 years) in the United States. PARTICIPANTS: The sample included 2038 older adults (49.4% aged 50-64 years and 50.6% aged 65-80 years, 51.2% women, M age = 63.6, standard deviation = 8.1). MEASUREMENTS: The modified Yale Food Addiction Scale 2.0 (validated measure that applies the diagnostic criteria for substance use disorder to the overconsumption of UPFs) was used to assess diagnostic criteria for UPFA. Various self-reported items were used to assess health-related domains (i.e., physical and mental health, social isolation). FINDINGS: The overall prevalence of UPFA was 12.4%, higher among women (16.9%) than men (7.5%), with the highest rate in women aged 50-64 (21%). Men reporting being overweight were 19.14 (95% confidence interval [CI] [5.26-69.66]) times more likely to meet the criteria for UPFA. Women reporting being overweight were 11.44 (95% CI [4.56-28.71]) times more likely to meet UFPA criteria. Women and men reporting worse physical health were 1.93 (95% CI [1.26-2.98]) times and 2.99 (95% CI [1.70-5.26]) times more likely to meet the criteria for UPFA, respectively. Similarly, women reporting worse mental health were 2.78 (95% CI [1.79-4.32]) times more likely to meet the criteria for UPFA, with men 4.02 (95% CI [2.19-7.38]) times more likely. Lastly, women and men reporting feelings of social isolation were 3.40 (95% CI [2.16-5.34]) times and 3.35 (95% CI [1.83-6.14]) times more likely to meet UFPA criteria. CONCLUSION: Ultra-processed food addiction appears to be prevalent among older adults in the United States, particularly among women who were in adolescence and early adulthood when the nutrient quality of the US food supply worsened. Addictive patterns of UPF intake appear to be associated with poorer physical health, mental health, and social well-being. CI - (c) 2025 The Author(s). Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction. FAU - Loch, Lucy K AU - Loch LK AUID- ORCID: 0009-0001-6608-8178 AD - Department of Psychology, University of Michigan, Ann Arbor, MI, USA. FAU - Kirch, Matthias AU - Kirch M AD - Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI, USA. FAU - Singer, Dianne C AU - Singer DC AD - Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI, USA. FAU - Solway, Erica AU - Solway E AD - Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI, USA. FAU - Roberts, J Scott AU - Roberts JS AD - Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI, USA. AD - Department of Health Behavior and Health Equity, School of Public Health, University of Michigan, Ann Arbor, MI, USA. FAU - Kullgren, Jeffrey T AU - Kullgren JT AD - Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI, USA. AD - Center for Clinical Management Research, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA. AD - Departments of Internal Medicine and Health Management and Policy, Schools of Medicine and Public Health, University of Michigan, Ann Arbor, MI, USA. FAU - Gearhardt, Ashley N AU - Gearhardt AN AUID- ORCID: 0000-0003-3843-5731 AD - Department of Psychology, University of Michigan, Ann Arbor, MI, USA. LA - eng GR - R01 DA055027/DA/NIDA NIH HHS/United States GR - DGE-2241144/National Science Foundation Graduate Research Fellowship Program/ GR - 5R01DA055027/DA/NIDA NIH HHS/United States GR - Michigan Medicine, University of Michigan/ GR - U.S. Department of Veterans Affairs/ GR - Health Services Research and Development/ GR - AARP Foundation (American Association of Retired Persons)/ PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20250929 PL - England TA - Addiction JT - Addiction (Abingdon, England) JID - 9304118 SB - IM MH - Humans MH - Female MH - Male MH - Middle Aged MH - Aged MH - United States/epidemiology MH - Cross-Sectional Studies MH - *Food Addiction/epidemiology MH - Aged, 80 and over MH - Prevalence MH - *Fast Foods/statistics & numerical data MH - Social Isolation MH - Food, Processed PMC - PMC12887916 OTO - NOTNLM OT - mental health OT - older adults OT - physical health OT - social isolation OT - ultra-processed food addiction OT - ultra-processed foods COIS- None to declare. EDAT- 2025/09/29 09:27 MHDA- 2026/02/10 13:31 PMCR- 2026/02/10 CRDT- 2025/09/29 05:10 PHST- 2024/09/13 00:00 [received] PHST- 2025/08/05 00:00 [accepted] PHST- 2026/02/10 13:31 [medline] PHST- 2025/09/29 09:27 [pubmed] PHST- 2025/09/29 05:10 [entrez] PHST- 2026/02/10 00:00 [pmc-release] AID - ADD70186 [pii] AID - 10.1111/add.70186 [doi] PST - ppublish SO - Addiction. 2026 Mar;121(3):510-521. doi: 10.1111/add.70186. Epub 2025 Sep 29. PMID- 41017415 OWN - NLM STAT- MEDLINE DCOM- 20250929 LR - 20251002 IS - 1748-2631 (Electronic) IS - 1748-2623 (Print) IS - 1748-2623 (Linking) VI - 20 IP - 1 DP - 2025 Dec 31 TI - Female body perception: social norms, criticism, and the impact of weight perception. PG - 2564088 LID - 10.1080/17482631.2025.2564088 [doi] LID - 2564088 AB - PURPOSE: This study aims to explore the multifaceted nature of women's body perception and the personal and social factors that influence it. The research investigates how societal expectations, health concerns, and self-perception intersect in shaping women's views of their own bodies. METHODS: Adopting a phenomenological approach, this qualitative study involved semi-structured interviews with 30 women aged 18-65 from diverse socioeconomic backgrounds. The data collection tool-a structured interview form-was developed through a literature review and expert consultation, and it was piloted for validity. Interviews were conducted both face-to-face and online, transcribed, and then analyzed using a phenomenologically informed thematic analysis. Three major themes were identified through high inter-rater agreement (over 90%): Physical Features and Health, Societal Pressures and Criticism, and Self-Perception and Emotions. RESULTS: Findings indicate that women's body perception is shaped by intersecting factors such as age, media portrayals, cultural norms, social surroundings, and lived experiences. Within the theme of Physical Features and Health, concerns around "Weight and Health" emerged most frequently, revealing the strong link between body perception and health consciousness. CONCLUSIONS: The study underscores the need for social and educational interventions that promote body positivity and challenge restrictive beauty norms. FAU - Sadik, Resat AU - Sadik R AUID- ORCID: 0000-0002-2312-8213 AD - Department of Sport Management, Faculty of Sport Sciences, Duzce University, Duzce, Turkey. FAU - Yilmaz, Gizem Nur AU - Yilmaz GN AUID- ORCID: 0009-0003-9193-0819 AD - Department of Sport Management, Faculty of Sport Sciences, Duzce University, Duzce, Turkey. LA - eng PT - Journal Article DEP - 20250929 PL - United States TA - Int J Qual Stud Health Well-being JT - International journal of qualitative studies on health and well-being JID - 101256506 SB - IM MH - Humans MH - Female MH - Adult MH - *Body Image/psychology MH - *Self Concept MH - Middle Aged MH - *Social Norms MH - Young Adult MH - Qualitative Research MH - Adolescent MH - *Body Weight MH - Aged MH - Emotions PMC - PMC12481526 OTO - NOTNLM OT - Body perception OT - beauty standards OT - body image OT - media influence OT - social norms OT - weight OT - women COIS- No potential conflict of interest was reported by the author(s). EDAT- 2025/09/29 09:27 MHDA- 2025/09/29 09:28 PMCR- 2025/09/29 CRDT- 2025/09/29 04:43 PHST- 2025/09/29 09:28 [medline] PHST- 2025/09/29 09:27 [pubmed] PHST- 2025/09/29 04:43 [entrez] PHST- 2025/09/29 00:00 [pmc-release] AID - 2564088 [pii] AID - 10.1080/17482631.2025.2564088 [doi] PST - ppublish SO - Int J Qual Stud Health Well-being. 2025 Dec 31;20(1):2564088. doi: 10.1080/17482631.2025.2564088. Epub 2025 Sep 29. PMID- 41017095 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20261016 IS - 2212-3873 (Electronic) IS - 1871-5303 (Print) IS - 1871-5303 (Linking) VI - 26 DP - 2026 TI - Associations of Mercury Exposure with Serum Sex Steroid Hormones in Children 6-18 Years from NHANES 2013-2016. PG - e18715303396515 LID - 10.2174/0118715303396515250912001734 [doi] LID - E18715303396515 AB - INTRODUCTION: To examine the relationship between mercury exposure and serum sex steroid hormones among children aged 6-18 years. METHODS: Data were collected from the NHANES 2013-2016. A cohort of 2,637 Children with available information on mercury exposure, serum sex steroid hormones, and covariates was enrolled. Generalized linear models were applied to explore the association of mercury exposure with sex steroid hormones. Finally, we adopted the Bayesian kernel machine regression (BKMR) model to investigate the effect of mixture exposure to mercury on hormone levels. RESULTS: Methyl mercury (MeHg) and total mercury (Hg) were associated with all sex steroid hormones except E2 (P <0.05). After adjusting for covariates, MeHg and Hg were related to sex hormone- binding globulin (SHBG) and free androgen index (FAI) (P <0.05). Stratified analysis by sex-puberty revealed a negative relationship between Hg and SHBG, while a positive association of MeHg with FAI in prepubertal girls (P <0.05). Their associations were confirmed by the BKMR model analysis, in which the mixture exposure was positively linked to FAI but inversely related to SHBG, particularly among prepubertal girls. DISCUSSION: These findings suggest that mercury may disrupt sex hormone homeostasis during critical developmental windows. Appropriate measures should be implemented to mitigate the adverse effects of mercury on sex hormones in the young population. However, future longitudinal large-scale studies are required for validation. CONCLUSION: Exposure to MeHg and Hg is associated with increased FAI levels, but decreased levels of SHBG, which are more pronounced in girls. The heightened susceptibility of prepubertal girls underscores the need for targeted public health interventions, including dietary guidance on seafood consumption and early biomonitoring of mercury levels in high-risk populations, to mitigate potential health impacts. FAU - Qiu, Binwei AU - Qiu B AD - Department of Pediatrics, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, Fujian, China. FAU - Lin, Yan AU - Lin Y AD - Department of Pediatrics, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, Fujian, China. LA - eng PT - Journal Article PL - United Arab Emirates TA - Endocr Metab Immune Disord Drug Targets JT - Endocrine, metabolic & immune disorders drug targets JID - 101269157 RN - 0 (Gonadal Steroid Hormones) RN - FXS1BY2PGL (Mercury) RN - 0 (Sex Hormone-Binding Globulin) RN - 0 (Methylmercury Compounds) SB - IM MH - Humans MH - Child MH - Female MH - Adolescent MH - Nutrition Surveys/trends MH - Male MH - *Gonadal Steroid Hormones/blood MH - *Mercury/adverse effects MH - *Environmental Exposure/adverse effects MH - Sex Hormone-Binding Globulin/metabolism/analysis MH - *Methylmercury Compounds/adverse effects MH - United States/epidemiology PMC - PMC13662729 OTO - NOTNLM OT - Mercury exposure OT - children OT - puberty status OT - public health OT - sex difference OT - sex steroid hormones OT - testosterone COIS- The authors confirm that there is no conflict of interest related to the manuscript. EDAT- 2025/09/29 09:27 MHDA- 2026/09/21 11:43 PMCR- 2026/10/14 CRDT- 2025/09/29 00:44 PHST- 2025/04/08 00:00 [received] PHST- 2025/06/17 00:00 [revised] PHST- 2025/07/03 00:00 [accepted] PHST- 2026/09/21 11:43 [medline] PHST- 2025/09/29 09:27 [pubmed] PHST- 2025/09/29 00:44 [entrez] PHST- 2026/10/14 00:00 [pmc-release] AID - EMIDDT-EPUB-150777 [pii] AID - EMIDDT-26-E18715303396515 [pii] AID - 10.2174/0118715303396515250912001734 [doi] PST - ppublish SO - Endocr Metab Immune Disord Drug Targets. 2026;26:e18715303396515. doi: 10.2174/0118715303396515250912001734. PMID- 41016710 OWN - NLM STAT- MEDLINE DCOM- 20251207 LR - 20260518 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 217 DP - 2026 Feb 1 TI - Association between caregivers' responsive feeding practices and the intake of fruit and vegetable among children aged 6-36 months: the mediating role of children's enjoyment of food. PG - 108325 LID - S0195-6663(25)00478-7 [pii] LID - 10.1016/j.appet.2025.108325 [doi] AB - This study examined the associations and mechanisms between caregivers' responsive/non-responsive feeding practices and fruit/vegetable intake of infants and toddlers in China. A combination of survey and homed-based video observation approach was adopted. In the survey (n = 408), caregivers' feeding practices were assessed using a pre-validated scale. Children's eating behaviors and daily amount (g/day) of fruit/vegetable intake were measured by Children's Eating Behavior Questionnaire and a food frequency questionnaire, respectively. In the video observation (n = 42), feeding episodes of 2-3 main meals captured caregiver-child interactions for description and analysis. Linear regression analysis of the survey data revealed that caregivers' responsiveness to cues was positively related to fruit (beta = 0.088, 95 % CI: 0.006, 0.171) and vegetable (beta = 0.094, 95 % CI: 0.015, 0.174) intake among children aged 25-36 months. Mediation analysis revealed that children's enjoyment of food eating behavior mediated the above significant association. These survey findings were supported by analysis from the video data. Moreover, the survey demonstrated that caregivers' modelling and controlling were related to fruit intake of children aged 6-24 months and 25-36 months, respectively (P < 0.05). Caregivers' encouraging to eat was positively associated, while emotional and instrumental feeding was negatively associated with vegetable intake among children aged 25-36 months (P < 0.05). To promote children's fruit and vegetable intake, caregivers might be educated to adopt responsive and avoid non-responsive feeding practices, with consideration of age specific strategies; and whose children aged 25-36 months might use responsiveness to cues feeding strategy. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - An, Meijing AU - An M AD - Department of Women's Health, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Liu, Xiyao AU - Liu X AD - Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, China. FAU - Wu, Nan AU - Wu N AD - Loudi Town Hospital of Luancheng District, Shijiazhuang City, Hebei Province, China. FAU - Zhou, Qianling AU - Zhou Q AD - Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, China. Electronic address: qianling.zhou@bjmu.edu.cn. LA - eng PT - Journal Article DEP - 20250926 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - Male MH - Infant MH - *Vegetables MH - *Fruit MH - Child, Preschool MH - *Feeding Behavior/psychology MH - *Caregivers/psychology MH - China MH - Surveys and Questionnaires MH - *Diet/psychology MH - Food Preferences/psychology MH - Adult MH - Child Behavior MH - Parenting/psychology OTO - NOTNLM OT - Enjoyment of food OT - Fruit and vegetable OT - Infants and toddlers OT - Questionnaire survey OT - Responsive feeding OT - Video observation COIS- Declaration of competing interest Declarations of interest: none. EDAT- 2025/09/29 00:32 MHDA- 2025/12/08 01:36 CRDT- 2025/09/28 19:40 PHST- 2025/05/21 00:00 [received] PHST- 2025/09/22 00:00 [revised] PHST- 2025/09/26 00:00 [accepted] PHST- 2025/12/08 01:36 [medline] PHST- 2025/09/29 00:32 [pubmed] PHST- 2025/09/28 19:40 [entrez] AID - S0195-6663(25)00478-7 [pii] AID - 10.1016/j.appet.2025.108325 [doi] PST - ppublish SO - Appetite. 2026 Feb 1;217:108325. doi: 10.1016/j.appet.2025.108325. Epub 2025 Sep 26. PMID- 41016664 OWN - NLM STAT- MEDLINE DCOM- 20251203 LR - 20251203 IS - 1938-3207 (Electronic) IS - 0002-9165 (Linking) VI - 122 IP - 6 DP - 2025 Dec TI - Associations between combined healthy lifestyle and adverse birth outcomes in 2 prospective cohorts: roles of gut microbiota and serum metabolites. PG - 1735-1747 LID - S0002-9165(25)00587-8 [pii] LID - 10.1016/j.ajcnut.2025.09.036 [doi] AB - BACKGROUND: Maternal lifestyle factors are reported to be associated with adverse birth outcomes (ABOs). These factors may also influence gut microbiota composition and serum metabolic profiles. OBJECTIVES: The aim of this study was to investigate the associations between combined healthy lifestyle and ABOs, and the mediating roles of gut microbiota and serum metabolites. METHODS: This study was conducted based on the Tongji-Huaxi-Shuangliu Birth Cohort (THSBC), comprising 1086 participants with repeated multiomics data collected at 3 time points. An independent validation was performed using 161 participants from the Huaxi Birth Cohort, with available multiomics data at 5 time points. Participants were classified into 3 lifestyle categories (unhealthy, low healthy, and highly healthy) according to diet, physical activity, smoking, drinking, sleep, and body mass index. Gut microbiota were characterized using 16S rRNA gene sequencing in the THSBC and metagenomics in the Huaxi Birth Cohort, whereas serum metabolites were profiled using untargeted liquid chromatography-mass spectrometry. Clinical data on birth outcomes, such as gestational age, birth weight, and sex, were collected in the THSBC. RESULTS: A highly healthy lifestyle was associated with lower risks of macrosomia (MAC) [odds ratio (OR): 0.43; 95% confidence interval (CI): 0.33, 0.57], preterm birth (PTB) (OR: 0.60; 95% CI: 0.46, 0.79), and large for gestational age (LGA) (OR: 0.44; 95% CI: 0.35, 0.56). Among the identified mediators, gut microbiota and serum metabolites, including Eisenbergiella, Tyzzerella, Megamonas, pro-Ile, and 1-amino-1-cyclobutane-carboxylic acid, were negatively associated with a healthy lifestyle, whereas Lachnospiraceae NK4A136 group, 4-methoxyestrone, and lysophosphatidylcholine [LPC(0:0/18:3)] were positively associated. Mediation analyses showed that Eisenbergiella and 4-methoxyestrone explained 11.4% and 13.0% of the inverse association between a highly healthy lifestyle and PTB, respectively, whereas the other microbiota and metabolites mediated 5%-7% of the associations with MAC and LGA. CONCLUSIONS: Maternal healthy lifestyle is associated with lower risk of ABOs, with gut microbiota and serum metabolites serving as important mediators in these relationships. CI - Copyright (c) 2025 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Dong, Yidan AU - Dong Y AD - Section of Epidemiology and Population Health & Department of Gynecology and Obstetrics, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children & Children's Medicine Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Zheng, Ju-Sheng AU - Zheng JS AD - Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China; Zhejiang Key Laboratory of Multi-Omics in Infection and Immunity, School of Medicine and School of Life Sciences, Westlake University, Hangzhou, China. FAU - Yang, Yunhaonan AU - Yang Y AD - Section of Epidemiology and Population Health & Department of Gynecology and Obstetrics, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children & Children's Medicine Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Wang, Tianlei AU - Wang T AD - Section of Epidemiology and Population Health & Department of Gynecology and Obstetrics, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children & Children's Medicine Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Li, Fan AU - Li F AD - Section of Epidemiology and Population Health & Department of Gynecology and Obstetrics, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children & Children's Medicine Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Wu, Ping AU - Wu P AD - Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Lai, Yuwei AU - Lai Y AD - Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Wang, Yuxiang AU - Wang Y AD - Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - He, Xiangwang AU - He X AD - Section of Epidemiology and Population Health & Department of Gynecology and Obstetrics, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children & Children's Medicine Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Zhang, Peiqi AU - Zhang P AD - Department of Epidemiology and Biostatistics, School of Public Health, Chengdu Medical College, Chengdu, Sichuan, China. FAU - Zhang, Shanshan AU - Zhang S AD - Section of Epidemiology and Population Health & Department of Gynecology and Obstetrics, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children & Children's Medicine Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Wu, Nianwei AU - Wu N AD - Section of Epidemiology and Population Health & Department of Gynecology and Obstetrics, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children & Children's Medicine Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Li, Shuo AU - Li S AD - Section of Epidemiology and Population Health & Department of Gynecology and Obstetrics, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children & Children's Medicine Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Yuan, Jiaying AU - Yuan J AD - Shuangliu Institute of Women's and Children's Health, Shuangliu Maternal and Child Health Hospital, Chengdu, Sichuan, China. FAU - Shan, Dan AU - Shan D AD - Section of Epidemiology and Population Health & Department of Gynecology and Obstetrics, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children & Children's Medicine Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Liu, Xiaojuan AU - Liu X AD - Department of Laboratory Medicine, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Liu, Gang AU - Liu G AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Hu, Yayi AU - Hu Y AD - Department of Obstetrics and Gynecology, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Pan, An AU - Pan A AD - Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address: panan@hust.edu.cn. FAU - Pan, Xiong-Fei AU - Pan XF AD - Section of Epidemiology and Population Health & Department of Gynecology and Obstetrics, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children & Children's Medicine Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China; Shuangliu Institute of Women's and Children's Health, Shuangliu Maternal and Child Health Hospital, Chengdu, Sichuan, China; West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address: pxiongfei@scu.edu.cn. LA - eng PT - Journal Article DEP - 20250926 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Humans MH - *Gastrointestinal Microbiome/physiology MH - Female MH - Adult MH - Prospective Studies MH - Pregnancy MH - Male MH - *Healthy Lifestyle MH - Infant, Newborn MH - *Pregnancy Outcome MH - Metabolome MH - Cohort Studies MH - Birth Cohort OTO - NOTNLM OT - birth outcomes OT - healthy lifestyle OT - metabolomics OT - microbiome OT - pregnancy OT - preterm birth COIS- Conflict of interest AP, serving as a member of the Editorial Board for The American Journal of Clinical Nutrition (AJCN), is a corresponding author of this manuscript. To ensure impartiality, AP recused himself from all editorial evaluation or decision-making processes related to this submission. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/09/29 00:31 MHDA- 2025/12/04 02:11 CRDT- 2025/09/28 19:39 PHST- 2025/03/21 00:00 [received] PHST- 2025/09/17 00:00 [revised] PHST- 2025/09/22 00:00 [accepted] PHST- 2025/12/04 02:11 [medline] PHST- 2025/09/29 00:31 [pubmed] PHST- 2025/09/28 19:39 [entrez] AID - S0002-9165(25)00587-8 [pii] AID - 10.1016/j.ajcnut.2025.09.036 [doi] PST - ppublish SO - Am J Clin Nutr. 2025 Dec;122(6):1735-1747. doi: 10.1016/j.ajcnut.2025.09.036. Epub 2025 Sep 26. PMID- 41014961 OWN - NLM STAT- Publisher LR - 20250927 IS - 1532-8384 (Electronic) IS - 0010-440X (Linking) VI - 143 DP - 2025 Sep 19 TI - Gaming disorder among Swedish adolescents: Measurement, risk factors, and classification. PG - 152635 LID - S0010-440X(25)00063-X [pii] LID - 10.1016/j.comppsych.2025.152635 [doi] AB - OBJECTIVES: This study examined the 1) psychometric properties of an independently translated Swedish version of the gaming disorder test (GDT) among Swedish adolescents based on two psychometric theories, 2) measurement invariance across age (i.e., 15 vs 16-17), gender (i.e., males vs females), and gaming time (i.e., < 2 h vs >/= 2 h), and 3) factors that predict gaming disorder. The findings will help researchers understand and ascertain the use of the GDT among Swedish adolescents. METHODS: A total of 5320 Swedish adolescents were recruited and responded to measures including gaming disorder, gaming duration, sleep duration, physical activity, mental well-being, and self-esteem. Statistical analyses were conducted using confirmatory factor analysis, regression analysis, latent class analysis, classical test theory, and Rasch analysis. RESULTS: Satisfactory and unidimensional psychometric properties for the independently translated Swedish version of the GDT were found. Specifically, the factor structure, internal consistencies, separation reliability and separation index were supported, but not the person separation reliability and index. Also, the GDT was invariant across ages but only partially so across gender and gaming time. The GDT can classify adolescents as having a high or low risk of gaming disorder. Lastly, factors that predicted gaming disorder were poorer mental well-being and longer gaming time among males and low physical activity and longer gaming time among females. CONCLUSION: Due to its conciseness, researchers may use the independently translated Swedish version of the GDT for screening people for gaming issues even in busy settings like schools. Moreover, attention must be paid to males, those with poorer mental well-being, those who are physically inactive, and those with a longer gaming time to help curb gaming disorder. Future research may focus on examining the test-retest reliability and clinical validity of the GDT among adolescents. CI - Copyright (c) 2025 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Pakpour, Amir AU - Pakpour A AD - Department of Nursing, School of Health and Welfare, Jonkoping University, Jonkoping, Sweden; CHILD research group, Department of Nursing Science, School of Health and Welfare, Jonkoping University, Jonkoping, Sweden. Electronic address: amir.pakpour@ju.se. FAU - Eriksson, Marit AU - Eriksson M AD - Futurum- the Academy for Health and Care, Region Jonkoping County, Jonkoping, Sweden; Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden. FAU - Ahorsu, Daniel Kwasi AU - Ahorsu DK AD - Department of Special Education and Counselling, The Education University of Hong Kong, Hong Kong, China. FAU - Bjorling, Gunilla AU - Bjorling G AD - Department of Nursing, School of Health and Welfare, Jonkoping University, Jonkoping, Sweden; Department of Neurobiology, Care Sciences, and Society, Karolinska Institute, Stockholm, Sweden; School of Nursing, KCMC University, Moshi, Tanzania. FAU - Brostrom, Anders AU - Brostrom A AD - Department of Nursing, School of Health and Welfare, Jonkoping University, Jonkoping, Sweden; Department of Clinical Neurophysiology, Linkoping University Hospital, Linkoping, Sweden; Department of Health and Caring Sciences, Western Norway University of Applied Sciences, Bergen, Vestlandet, Norway. FAU - Bengtsson, Staffan AU - Bengtsson S AD - CHILD research group, Department of Nursing Science, School of Health and Welfare, Jonkoping University, Jonkoping, Sweden; Department of Social Work, School of Health and Welfare, Jonkoping University, Jonkoping, Sweden. FAU - Jakobsson, Malin AU - Jakobsson M AD - Department of Nursing, School of Health and Welfare, Jonkoping University, Jonkoping, Sweden; CHILD research group, Department of Nursing Science, School of Health and Welfare, Jonkoping University, Jonkoping, Sweden. FAU - Huus, Karina AU - Huus K AD - Department of Nursing, School of Health and Welfare, Jonkoping University, Jonkoping, Sweden; CHILD research group, Department of Nursing Science, School of Health and Welfare, Jonkoping University, Jonkoping, Sweden. LA - eng PT - Journal Article DEP - 20250919 PL - United States TA - Compr Psychiatry JT - Comprehensive psychiatry JID - 0372612 SB - IM OTO - NOTNLM OT - Classical test theory OT - Rasch analysis OT - general health OT - mental well-being OT - physical activity COIS- Declaration of competing interest The authors have no competing interests to declare. EDAT- 2025/09/28 01:02 MHDA- 2025/09/28 01:02 CRDT- 2025/09/27 18:09 PHST- 2024/11/25 00:00 [received] PHST- 2025/08/18 00:00 [revised] PHST- 2025/09/03 00:00 [accepted] PHST- 2025/09/28 01:02 [medline] PHST- 2025/09/28 01:02 [pubmed] PHST- 2025/09/27 18:09 [entrez] AID - S0010-440X(25)00063-X [pii] AID - 10.1016/j.comppsych.2025.152635 [doi] PST - aheadofprint SO - Compr Psychiatry. 2025 Sep 19;143:152635. doi: 10.1016/j.comppsych.2025.152635. PMID- 41014828 OWN - NLM STAT- MEDLINE DCOM- 20251202 LR - 20251202 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 85 DP - 2025 Nov-Dec TI - Measurement tools for assessing nausea, vomiting, and retching in pediatric populations: A scoping review. PG - 567-576 LID - S0882-5963(25)00333-1 [pii] LID - 10.1016/j.pedn.2025.09.019 [doi] AB - BACKGROUND: Nausea, vomiting, and retching are distressing symptoms in pediatric patients, yet their assessment remains inconsistent due to a lack of standardized, age-appropriate tools aligned with children's developmental needs. AIM: This scoping review aimed to identify, map, and evaluate the tools currently used to measure nausea, vomiting, and retching in pediatric populations, specifically focusing on their psychometric properties, applicability, and limitations in clinical and research settings. METHOD: The review followed the PRISMA-ScR and Joanna Briggs Institute guidelines. A comprehensive search was conducted across six databases (PubMed, Web of Science, Cochrane Library, MEDLINE, CINAHL, and Scopus) up to January 2025. RESULTS: A total of 14 studies met the inclusion criteria, covering 14 measurement tools. Most tools (n = 14) were developed for self-report use, while 10 incorporated proxy-report methods. Tools varied in their focus, with several designed for oncology settings (e.g., BARF Scale, PeNAT, NVTS, SSPedi), while others addressed gastrointestinal disorders, chronic kidney disease, or brain tumors. Outcomes assessed included nausea intensity, vomiting, retching, pain, dietary intake, functional impairment, and emotional symptoms. PRACTICE IMPLICATIONS: Existing tools provide useful insights into pediatric nausea and vomiting but differ widely in design and applicability. Standardized, age-appropriate, and culturally adaptable tools are urgently needed for accurate assessment in pediatric patients. CONCLUSION: Most tools demonstrated acceptable reliability and validity; limited sensitivity for younger children, proxy-report variability, and cultural adaptation were noted. Current tools offer valuable insights into pediatric nausea and vomiting but vary significantly in design, scope, and applicability. CI - Copyright (c) 2025 Elsevier Inc. All rights reserved. FAU - Semerci Sahin, Remziye AU - Semerci Sahin R AD - Koc University, School of Nursing, Department of Pediatric Nursing, Istanbul, Turkey. Electronic address: remziyesemerci@gmail.com. FAU - Kucukkaya, Aycan AU - Kucukkaya A AD - Istanbul University-Cerrahpasa, Institute of Graduate Studies, Istanbul, Turkey. FAU - Cakir, Gokce Naz AU - Cakir GN AD - Istanbul Gedik University, Faculty of Health Sciences, Department of Nursing, Istanbul, Turkey. Electronic address: cakirgokcenaz@gmail.com. FAU - Akdeniz Kudubes, Asli AU - Akdeniz Kudubes A AD - Bilecik Seyh Edebali University, Faculty of Health Sciences, Department of Child Health and Diseases Nursing, Bilecik, Turkey. FAU - Goktas, Polat AU - Goktas P AD - UCD School of Computer Science, University College Dublin, Dublin, Ireland. LA - eng PT - Journal Article PT - Scoping Review DEP - 20250926 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM MH - Child MH - Female MH - Humans MH - Male MH - *Nausea/diagnosis MH - Psychometrics MH - Reproducibility of Results MH - *Vomiting/diagnosis OTO - NOTNLM OT - Nausea OT - Pediatric OT - Retching OT - Symptom assessment OT - Vomiting COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/09/28 01:03 MHDA- 2025/12/02 07:37 CRDT- 2025/09/27 18:06 PHST- 2025/04/30 00:00 [received] PHST- 2025/09/19 00:00 [revised] PHST- 2025/09/19 00:00 [accepted] PHST- 2025/12/02 07:37 [medline] PHST- 2025/09/28 01:03 [pubmed] PHST- 2025/09/27 18:06 [entrez] AID - S0882-5963(25)00333-1 [pii] AID - 10.1016/j.pedn.2025.09.019 [doi] PST - ppublish SO - J Pediatr Nurs. 2025 Nov-Dec;85:567-576. doi: 10.1016/j.pedn.2025.09.019. Epub 2025 Sep 26. PMID- 41014241 OWN - NLM STAT- MEDLINE DCOM- 20260106 LR - 20260919 IS - 1098-108X (Electronic) IS - 0276-3478 (Print) IS - 0276-3478 (Linking) VI - 59 IP - 1 DP - 2026 Jan TI - Greater Body Dissatisfaction at Admission Is Associated With Lower BMI at Discharge in Anorexia Nervosa: Predictive Validity of the Eating Pathology Symptoms Inventory. PG - 90-98 LID - 10.1002/eat.24560 [doi] AB - People with anorexia nervosa (AN) engage in dietary restriction and other weight loss behaviors that result in dangerously low body weight, leading to an increased risk for mortality and medical complications. Weight gain is one of the most important indicators of treatment progress and recovery for AN. There are limited predictors of weight gain for patients with AN, making it difficult for clinicians to anticipate which patients are likely to respond favorably to treatment. Thus, there is a need to identify additional, potentially modifiable predictors of weight gain within a higher level of care for AN. This study tested the predictive validity of the Eating Pathology Symptoms Inventory (EPSI) in adults receiving a higher level of care for AN (N = 340). We hypothesized that EPSI scores at treatment admission would predict body mass index (BMI) at discharge. Linear regression was used to identify predictors of discharge BMI. EPSI Body Dissatisfaction at admission (beta = -0.043, p = 0.005) predicted BMI at discharge (controlling for admission BMI, length of stay, and level of care), such that individuals with greater body dissatisfaction at admission had lower BMIs at treatment discharge. Other EPSI scales did not predict BMI. Results supported the predictive validity of EPSI Body Dissatisfaction for discharge weight in adults receiving a higher level of care for AN. Patients who are more dissatisfied with their bodies, despite having a dangerously low BMI at admission, may be at risk for poorer treatment outcomes. CI - (c) 2025 The Author(s). International Journal of Eating Disorders published by Wiley Periodicals LLC. FAU - Chapa, Danielle A N AU - Chapa DAN AUID- ORCID: 0000-0001-6946-4194 AD - Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Thomeczek, Marianna L AU - Thomeczek ML AUID- ORCID: 0000-0002-7098-8697 AD - Department of Psychology, University of Kansas, Lawrence, Kansas, USA. FAU - Richson, Brianne N AU - Richson BN AUID- ORCID: 0000-0002-0812-6500 AD - Sanford Center for Biobehavioral Research, Fargo, North Dakota, USA. AD - Department of Psychiatry and Behavioral Science, University of North Dakota, Fargo, North Dakota, USA. FAU - Duffy, Alan AU - Duffy A AUID- ORCID: 0000-0002-8697-9285 AD - Eating Recovery Center and Pathlight Mood & Anxiety Center, Chicago, Illinois, USA. FAU - Christensen Pacella, Kara A AU - Christensen Pacella KA AUID- ORCID: 0000-0002-5099-0570 AD - Department of Psychology, University of Nevada Las Vegas, Las Vegas, Nevada, USA. FAU - Forbush, Kelsie T AU - Forbush KT AUID- ORCID: 0000-0002-5900-4204 AD - Department of Clinical Child Psychology, University of Kansas, Lawrence, Kansas, USA. AD - Lifespan Institute, University of Kansas, Lawrence, Kansas, USA. FAU - Rienecke, Renee D AU - Rienecke RD AUID- ORCID: 0000-0003-0423-7403 AD - Eating Recovery Center and Pathlight Mood & Anxiety Center, Chicago, Illinois, USA. AD - Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, Illinois, USA. FAU - Blalock, Dan V AU - Blalock DV AUID- ORCID: 0000-0002-8349-9825 AD - Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA. AD - Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT), Durham Veterans Affairs Medical Center, Durham, North Carolina, USA. FAU - Gould, Sara R AU - Gould SR AUID- ORCID: 0000-0001-5651-3516 AD - Children's Mercy Hospital, Kansas City, Missouri, USA. FAU - Perko, Victoria L AU - Perko VL AUID- ORCID: 0000-0001-5311-6363 AD - ReefPoint Group, Annapolis, Maryland, USA. FAU - Mehler, Philip S AU - Mehler PS AUID- ORCID: 0000-0002-9598-6428 AD - Eating Recovery Center and Pathlight Mood & Anxiety Center, Chicago, Illinois, USA. AD - ACUTE Center for Eating Disorders at Denver Health, Denver, Colorado, USA. AD - School of Medicine, University of Colorado, Denver, Colorado, USA. LA - eng GR - T32 MH018269/MH/NIMH NIH HHS/United States GR - T32 MH082761/MH/NIMH NIH HHS/United States GR - NIMH T32 MH082761/MH/NIMH NIH HHS/United States GR - NIMH T32 MH018269/MH/NIMH NIH HHS/United States GR - NIMH T32 MH018269/MH/NIMH NIH HHS/United States GR - NIMH T32 MH082761/MH/NIMH NIH HHS/United States PT - Journal Article DEP - 20250927 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM MH - Humans MH - *Anorexia Nervosa/psychology/therapy/diagnosis MH - Female MH - *Body Mass Index MH - Adult MH - *Body Dissatisfaction/psychology MH - Patient Discharge MH - Young Adult MH - Male MH - Adolescent MH - *Body Image/psychology MH - Reproducibility of Results MH - Weight Gain PMC - PMC12614634 MID - NIHMS2113495 OTO - NOTNLM OT - anorexia nervosa OT - bmi OT - eating disorders OT - eating pathology symptoms inventory OT - predictive validity OT - psychometrics OT - treatment outcomes COIS- Dr. Blalock receives consulting fees from Eating Recovery Center/Pathlight Mood and Anxiety Center. Dr. Renee Rienecke receives consulting fees from the Training Institute for Child and Adolescent Eating Disorders LLC, and receives royalties from Routledge and Hachette Book Group Inc. EDAT- 2025/09/27 12:35 MHDA- 2026/01/06 19:17 PMCR- 2026/01/06 CRDT- 2025/09/27 08:53 PHST- 2025/09/16 00:00 [revised] PHST- 2025/05/22 00:00 [received] PHST- 2025/09/17 00:00 [accepted] PHST- 2026/01/06 19:17 [medline] PHST- 2025/09/27 12:35 [pubmed] PHST- 2025/09/27 08:53 [entrez] PHST- 2026/01/06 00:00 [pmc-release] AID - EAT24560 [pii] AID - 10.1002/eat.24560 [doi] PST - ppublish SO - Int J Eat Disord. 2026 Jan;59(1):90-98. doi: 10.1002/eat.24560. Epub 2025 Sep 27. PMID- 41013861 OWN - NLM STAT- MEDLINE DCOM- 20250927 LR - 20260328 IS - 2072-1315 (Electronic) IS - 1606-0997 (Print) IS - 1606-0997 (Linking) VI - 44 IP - 1 DP - 2025 Sep 26 TI - Veggies4myHeart digital game: an educational tool to promote vegetable consumption in preschool children - a multicentre experimental study. PG - 326 LID - 10.1186/s41043-025-01074-z [doi] LID - 326 AB - BACKGROUND: Vegetable consumption as part of a balanced and diversified dietary pattern is associated with a lower risk of cardiovascular disease, cancer, and all-cause mortality. Even though the scientific evidence for these benefits is strong, the consumption of vegetables remains far below recommendations, especially in early childhood. Despite existing literature, the evidence on how to increase vegetable consumption in preschool children remains limited and the development and validation of new strategies should be pursued in varied contexts. The study presented herein aimed to compare the impact of educational sessions based on the serious game Veggies4myHeart and repeated exposure to vegetables on preschool children's willingness to taste them and also their nutrition knowledge, measured at baseline and post-intervention, in Portuguese and Swiss preschool children. METHODS: The intervention was carried out in preschools with 39 Portuguese and 45 Swiss children, from 3 to 6 years old, in their preschools, between May 2019 and February 2021. Children participated in weekly 20-minute educational sessions for 5 weeks, delivered by trained nutritionists and incorporating the Veggies4myHeart digital game. Willingness to taste was assessed by offering the five raw vegetables in standard portions and recording whether each child tasted them at baseline, throughout the intervention, and post-intervention. Nutrition knowledge was assessed using three questionnaires applied before and after the intervention. Data were analysed using IBM SPSS software and statistical significance was set at p-value < 0.05. RESULTS: Comparing the results between the two countries post-intervention, statistically significant differences were found in the willingness to taste lettuce, carrot, and red cabbage, with Portuguese children showing more willingness to taste these vegetables than Swiss children (p < 0,05). Improvements in nutrition knowledge, from baseline to post-intervention, were observed in both countries (p < 0,001), but without statistically significant differences between countries (p = 0.114). CONCLUSIONS: Despite differences in context and eating habits of Portuguese and Swiss children, the intervention with the Veggies4myHeart digital game increased preschoolers' willingness to taste vegetables, supporting the value of repeated exposure combined with digital tools. Improvement in nutrition knowledge further reinforces the potential of serious games as comprehensive educational strategies for promoting healthy habits in young children. CI - (c) 2025. The Author(s). FAU - Braga-Pontes, Catia AU - Braga-Pontes C AD - ciTechCare- Center for Innovative Care and Health Technology, Polytechnic University of Leiria, Leiria, Portugal. catia.pontes@ipleiria.pt. AD - School of Health Sciences, Polytechnic University of Leiria, Leiria, Portugal. catia.pontes@ipleiria.pt. FAU - Ferreira, Patricia V AU - Ferreira PV AD - ciTechCare- Center for Innovative Care and Health Technology, Polytechnic University of Leiria, Leiria, Portugal. FAU - Barros, Neuza AU - Barros N AD - ciTechCare- Center for Innovative Care and Health Technology, Polytechnic University of Leiria, Leiria, Portugal. FAU - Vieito, Leonel AU - Vieito L AD - ciTechCare- Center for Innovative Care and Health Technology, Polytechnic University of Leiria, Leiria, Portugal. FAU - Lages, Marlene AU - Lages M AD - ciTechCare- Center for Innovative Care and Health Technology, Polytechnic University of Leiria, Leiria, Portugal. FAU - Simoes-Dias, Sara AU - Simoes-Dias S AD - ciTechCare- Center for Innovative Care and Health Technology, Polytechnic University of Leiria, Leiria, Portugal. AD - School of Health Sciences, Polytechnic University of Leiria, Leiria, Portugal. FAU - Torre, Sophie Bucher Della AU - Torre SBD AD - Department of Nutrition and Dietetics, Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western, Geneva, Switzerland. FAU - Guarino, Maria P AU - Guarino MP AD - ciTechCare- Center for Innovative Care and Health Technology, Polytechnic University of Leiria, Leiria, Portugal. AD - School of Health Sciences, Polytechnic University of Leiria, Leiria, Portugal. LA - eng GR - UID/05704/2023/Fundacao para a Ciencia e Tecnologia (FCT)/ GR - UID/05704/2023/Fundacao para a Ciencia e Tecnologia (FCT)/ GR - UID/05704/2023/Fundacao para a Ciencia e Tecnologia (FCT)/ GR - UID/05704/2023/Fundacao para a Ciencia e Tecnologia (FCT)/ GR - UID/05704/2023/Fundacao para a Ciencia e Tecnologia (FCT)/ GR - UID/05704/2023/Fundacao para a Ciencia e Tecnologia (FCT)/ GR - UID/05704/2023/Fundacao para a Ciencia e Tecnologia (FCT)/ PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20250926 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 SB - IM MH - Humans MH - Child, Preschool MH - *Vegetables MH - Portugal MH - Male MH - Female MH - Switzerland MH - *Video Games MH - *Health Promotion/methods MH - Health Knowledge, Attitudes, Practice MH - Child MH - *Health Education/methods MH - Feeding Behavior MH - Food Preferences PMC - PMC12465687 OTO - NOTNLM OT - Education OT - Food preferences OT - Obesity prevention OT - Serious games OT - Vegetables COIS- Declarations. Ethics approval and consent to participate: This study was conducted according to the guidelines laid down in the Declaration of Helsinki and all procedures involving research study participants were approved by the Ethical Committee of Polytechnic Institute of Leiria. Written informed consent was obtained from all the parents of children enrolled in the study and a verbal assent was obtained from all children. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. This study was approved by the Ethical Committee of Polytechnic Institute of Leiria (CE/IPLEIRIA/11/2019) and by the Service of Research in Education in Geneva, Switzerland (research number 584). EDAT- 2025/09/27 06:33 MHDA- 2025/09/27 12:34 PMCR- 2025/09/26 CRDT- 2025/09/27 02:10 PHST- 2025/03/26 00:00 [received] PHST- 2025/08/26 00:00 [accepted] PHST- 2025/09/27 12:34 [medline] PHST- 2025/09/27 06:33 [pubmed] PHST- 2025/09/27 02:10 [entrez] PHST- 2025/09/26 00:00 [pmc-release] AID - 10.1186/s41043-025-01074-z [pii] AID - 1074 [pii] AID - 10.1186/s41043-025-01074-z [doi] PST - epublish SO - J Health Popul Nutr. 2025 Sep 26;44(1):326. doi: 10.1186/s41043-025-01074-z. PMID- 41010542 OWN - NLM STAT- MEDLINE DCOM- 20250927 LR - 20250930 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 18 DP - 2025 Sep 21 TI - Social Media Consumption and Risk of Addiction Associated with Adolescent Disordered Eating Behaviour: An Observational Analysis. LID - 10.3390/nu17183017 [doi] LID - 3017 AB - OBJECTIVES: To examine the association between social media (SM) use and content exposure with the risk of developing eating disorders (EDs) among adolescents. METHODS: A descriptive observational study was conducted using a structured questionnaire incorporating validated scales. The instrument assessed quantitative and qualitative variables related to eating habits, SM usage, self-esteem, and body image. The sample comprised students aged 12-17 years from a school in Cordoba, Spain. RESULTS: A total of 115 students participated in the study. Among them, 43.5% were identified as being at risk of developing EDs. Of this subgroup, 54.0% were female, with male gender appearing as a protective factor against ED risk. A significant association was found between increased hours of SM use and higher ED risk, with an odds ratio (OR) of 5.54 (95% confidence interval [CI]: 2.03-14.33). CONCLUSIONS: The findings suggest that low self-esteem and negative body image are key factors associated with increased ED risk, and that SM may act as an amplifying influence. Preventive interventions should focus on enhancing self-esteem and fostering critical and conscious engagement with SM among adolescents to mitigate the development of eating disorders. FAU - Perez-Jimenez, Maria AU - Perez-Jimenez M AD - Nursing, Pharmacology and Physiotherapy Department, University of Cordoba, 14004 Cordoba, Spain. FAU - Ucles-Torrente, Maria Del Mar AU - Ucles-Torrente MDM AD - Nursing, Pharmacology and Physiotherapy Department, University of Cordoba, 14004 Cordoba, Spain. AD - GE10 Clinical and Epidemiological Research in Primary Care (GICEAP), Maimonides Biomedical Research Institute of Cordoba (IMIBIC), 14004 Cordoba, Spain. AD - Biomedicine Program, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, 14071 Cordoba, Spain. FAU - Ruiz-Gamarra, Gema Esperanza AU - Ruiz-Gamarra GE AD - GE10 Clinical and Epidemiological Research in Primary Care (GICEAP), Maimonides Biomedical Research Institute of Cordoba (IMIBIC), 14004 Cordoba, Spain. AD - Biomedicine Program, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, 14071 Cordoba, Spain. AD - Palma del Rio Health Center, Dr. Trujillo Street, Palma del Rio, 14700 Cordoba, Spain. FAU - Vaquero-Alvarez, Manuel AU - Vaquero-Alvarez M AUID- ORCID: 0000-0001-9730-6310 AD - Grupo Investigacion GC09 Nutrigenomics, Metabolic Syndrome, Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), 14004 Cordoba, Spain. AD - Faculty of Medicine and Nursing, University of Cordoba, 14071 Cordoba, Spain. FAU - Blancas-Sanchez, Isabel Maria AU - Blancas-Sanchez IM AD - Grupo Investigacion GC09 Nutrigenomics, Metabolic Syndrome, Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), 14004 Cordoba, Spain. AD - Occidente Azahara Healthcare Center Cordoba, 14011 Cordoba, Spain. FAU - Aparicio-Martinez, Pilar AU - Aparicio-Martinez P AUID- ORCID: 0000-0002-2940-8697 AD - Nursing, Pharmacology and Physiotherapy Department, University of Cordoba, 14004 Cordoba, Spain. AD - GE10 Clinical and Epidemiological Research in Primary Care (GICEAP), Maimonides Biomedical Research Institute of Cordoba (IMIBIC), 14004 Cordoba, Spain. FAU - Vaquero-Abellan, Manuel AU - Vaquero-Abellan M AUID- ORCID: 0000-0002-0602-317X AD - Nursing, Pharmacology and Physiotherapy Department, University of Cordoba, 14004 Cordoba, Spain. AD - GE10 Clinical and Epidemiological Research in Primary Care (GICEAP), Maimonides Biomedical Research Institute of Cordoba (IMIBIC), 14004 Cordoba, Spain. LA - eng PT - Journal Article PT - Observational Study DEP - 20250921 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - Female MH - *Feeding and Eating Disorders/psychology/epidemiology/etiology MH - Male MH - *Social Media/statistics & numerical data MH - Self Concept MH - Body Image/psychology MH - Child MH - *Behavior, Addictive/psychology/epidemiology MH - Surveys and Questionnaires MH - Spain/epidemiology MH - *Feeding Behavior/psychology MH - Risk Factors MH - *Adolescent Behavior/psychology MH - Students/psychology PMC - PMC12472393 OTO - NOTNLM OT - adolescent OT - eating disorders OT - ideal body weight OT - self-concept OT - social networking COIS- The authors declare no conflicts of interest. EDAT- 2025/09/27 06:33 MHDA- 2025/09/27 06:34 PMCR- 2025/09/21 CRDT- 2025/09/27 01:18 PHST- 2025/08/29 00:00 [received] PHST- 2025/09/17 00:00 [revised] PHST- 2025/09/18 00:00 [accepted] PHST- 2025/09/27 06:34 [medline] PHST- 2025/09/27 06:33 [pubmed] PHST- 2025/09/27 01:18 [entrez] PHST- 2025/09/21 00:00 [pmc-release] AID - nu17183017 [pii] AID - nutrients-17-03017 [pii] AID - 10.3390/nu17183017 [doi] PST - epublish SO - Nutrients. 2025 Sep 21;17(18):3017. doi: 10.3390/nu17183017. PMID- 41010541 OWN - NLM STAT- MEDLINE DCOM- 20250927 LR - 20250930 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 18 DP - 2025 Sep 20 TI - The Impact of Physical Education Attendance and Diet on Bone Mineralization in Adolescents. LID - 10.3390/nu17183016 [doi] LID - 3016 AB - Background: Bone mineralization can be influenced by physical activity and dietary factors; however, the relative contributions of these factors are not well defined. Physical activity in adolescents can be implemented with physical education (PE) classes and there is no reported data on their impact on bone mineralization. This study investigates the relationship between PE class attendance, dietary factors, and bone mineralization in adolescents. Methods: 57 adolescents (median age 17.00 [16.00-17.00] years) were enrolled in this study. Bone mineralization was assessed with bioelectrical impedance analysis (BIA) and dietary knowledge and selected foods intakes were assessed with a validated questionnaire. Results: PE attendance and dietary knowledge were positively associated with bone mineralization in the multivariate models (R(2) = 0.85, p < 0.001 for the best model, and R(2) = 0.81, p < 0.001 for the simplified model), and PE attendance was the dominant positive factor among the modifiable ones (B = 0.20, p = 0.02, and B = 0.25, p = 0.004, respectively). The impact of calcium sources intake was diminished when controlled for PE class attendance. Conclusions: PE attendance is one of the key factors of bone mineralization in adolescents. Our study showed that the role of calcium sources intake was diminished when acknowledging physical activity data, however dietary knowledge remained a significant predictor. Enhancing dietary knowledge and promoting physical activity are key targets for improving bone health. FAU - Przytula, Agata AU - Przytula A AUID- ORCID: 0009-0006-3818-8960 AD - Department of Clinical Dietetics, Medical University of Lublin, ul. Chodzki 7, 20-093 Lublin, Poland. FAU - Popiolek-Kalisz, Joanna AU - Popiolek-Kalisz J AUID- ORCID: 0000-0001-9108-8391 AD - Department of Clinical Dietetics, Medical University of Lublin, ul. Chodzki 7, 20-093 Lublin, Poland. AD - Department of Cardiology, Cardinal Wyszynski Hospital in Lublin, al. Krasnicka 100, 20-718 Lublin, Poland. LA - eng GR - DS 672/Medical University of Lublin/ PT - Journal Article DEP - 20250920 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Calcium, Dietary) SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - *Calcification, Physiologic/physiology MH - *Diet MH - *Physical Education and Training MH - Exercise MH - Calcium, Dietary/administration & dosage MH - *Bone Density MH - Health Knowledge, Attitudes, Practice MH - Surveys and Questionnaires MH - Electric Impedance PMC - PMC12472207 OTO - NOTNLM OT - adolescents OT - bioelectrical impedance analysis OT - bone mineralization OT - dietary knowledge OT - physical education COIS- The authors declare no conflicts of interest. EDAT- 2025/09/27 06:33 MHDA- 2025/09/27 06:34 PMCR- 2025/09/20 CRDT- 2025/09/27 01:18 PHST- 2025/08/28 00:00 [received] PHST- 2025/09/16 00:00 [revised] PHST- 2025/09/19 00:00 [accepted] PHST- 2025/09/27 06:34 [medline] PHST- 2025/09/27 06:33 [pubmed] PHST- 2025/09/27 01:18 [entrez] PHST- 2025/09/20 00:00 [pmc-release] AID - nu17183016 [pii] AID - nutrients-17-03016 [pii] AID - 10.3390/nu17183016 [doi] PST - epublish SO - Nutrients. 2025 Sep 20;17(18):3016. doi: 10.3390/nu17183016. PMID- 41010505 OWN - NLM STAT- MEDLINE DCOM- 20250927 LR - 20250930 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 18 DP - 2025 Sep 17 TI - Validating Sentinel Foods in the Diet Quality Questionnaire: Insights from Two Chilean Cohorts of Pregnant Women and Children. LID - 10.3390/nu17182980 [doi] LID - 2980 AB - Background: New tools for monitoring diets, such as the Diet Quality Questionnaire (DQQ), may help reduce the costs and burden associated with traditional methods of diet assessment. However, its proposed sentinel foods require validation in target populations. This study aimed to validate the Chilean sentinel foods and describe the performance of DQQ, as well as its Global Dietary Recommendation (GDR) indicators, in two Chilean cohorts. Methods: We analyzed dietary data from 1418 pregnant women and 799 children using 24 h recalls. Foods and beverages were classified and ranked into 29 DQQ food groups. Food items that accounted for more than 95% of the total consumption within each of the 29 food groups were selected and identified as sentinels. We estimated the proportion of consumers in each food group and calculated the indicators, as well as their relationship with the consumption of ultra-processed foods (UPFs). Results: The pregnant women had a mean age of 29.1 (SD 6.6), and the children had a mean age of 6.2 (SD 0.5). The sentinel foods of six groups (grain-based sweets, other sweets, salty snacks, deep-fried food, and sweet tea/coffee/cocoa) captured under 95% of the group's total consumption. The pregnant women had a higher frequency of consumption of staple and healthy foods, and the mean GDR score was 9.3 (SD 2.20). The children had higher consumption of unhealthy food groups, and the mean GDR score was 8.1 (SD 2.05). The GDR-protect scores showed a moderate but statistically significant negative correlation with ultra-processed food consumption (p-value < 0.0001). Conclusions: The DQQ is a suitable tool for collecting dietary data to estimate diet quality using food group-based indicators. Additionally, it is possible to identify different dietary patterns at a crucial stage of life, such as childhood and pregnancy. However, it requires some adaptations of sentinel foods and further testing on other populations before it can be implemented to monitor Chilean diets. FAU - Martinez-Arroyo, Angela AU - Martinez-Arroyo A AUID- ORCID: 0000-0001-6380-5701 AD - Centro de Investigacion del Comportamiento Alimentario (CEIC), Facultad de Farmacia, Escuela de Nutricion y Dietetica, Universidad de Valparaiso, Valparaiso 2381850, Chile. FAU - Barisione, Giannella AU - Barisione G AUID- ORCID: 0009-0005-0256-5931 AD - Centro de Investigacion del Comportamiento Alimentario (CEIC), Facultad de Farmacia, Escuela de Nutricion y Dietetica, Universidad de Valparaiso, Valparaiso 2381850, Chile. FAU - Vizcarra, Marcela AU - Vizcarra M AD - Centro de Investigacion del Comportamiento Alimentario (CEIC), Facultad de Farmacia, Escuela de Nutricion y Dietetica, Universidad de Valparaiso, Valparaiso 2381850, Chile. FAU - Rebolledo, Natalia AU - Rebolledo N AUID- ORCID: 0000-0002-4537-6592 AD - Center for Research in Food Environments and Prevention of Nutrition-Related Chronic Diseases (CIAPEC), Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago 7830490, Chile. FAU - Garmendia, Maria Luisa AU - Garmendia ML AUID- ORCID: 0000-0002-0589-6091 AD - Center for Research in Food Environments and Prevention of Nutrition-Related Chronic Diseases (CIAPEC), Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago 7830490, Chile. LA - eng PT - Journal Article PT - Validation Study DEP - 20250917 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Chile MH - Adult MH - *Diet Surveys/methods MH - *Diet MH - Child MH - Surveys and Questionnaires MH - Cohort Studies MH - Reproducibility of Results MH - Male MH - Nutrition Assessment MH - Young Adult PMC - PMC12473036 OTO - NOTNLM OT - Diet Quality Questionnaire OT - children OT - diet quality OT - food consumption OT - pregnant women COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/09/27 06:33 MHDA- 2025/09/27 06:34 PMCR- 2025/09/17 CRDT- 2025/09/27 01:18 PHST- 2025/07/26 00:00 [received] PHST- 2025/09/07 00:00 [revised] PHST- 2025/09/11 00:00 [accepted] PHST- 2025/09/27 06:34 [medline] PHST- 2025/09/27 06:33 [pubmed] PHST- 2025/09/27 01:18 [entrez] PHST- 2025/09/17 00:00 [pmc-release] AID - nu17182980 [pii] AID - nutrients-17-02980 [pii] AID - 10.3390/nu17182980 [doi] PST - epublish SO - Nutrients. 2025 Sep 17;17(18):2980. doi: 10.3390/nu17182980. PMID- 41009266 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250927 LR - 20250930 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 15 IP - 9 DP - 2025 Sep 11 TI - Longitudinal Association Between Physical Activity and School Bullying in Adolescents: A Cross-Lagged Panel Model. LID - 10.3390/bs15091236 [doi] LID - 1236 AB - BACKGROUND: School bullying represents a critical global public health issue among adolescents. Although existing evidence suggests physical activity (PA) may reduce bullying risk, longitudinal data on bidirectional associations and gender-specific variations remain limited. This study employed a cross-lagged panel model (CLPM) to investigate the temporal dynamics between PA and school bullying (SB) and examine gender-moderating effects. METHODS: A cohort of 577 middle school students (294 boys, 283 girls; mean age = 14.31 +/- 2.1 years) from seven schools across Wuhan, Shijiazhuang, and Chengdu completed three-wave longitudinal assessments over 9 months (September 2024-March 2025). Validated instruments included the School Bullying Scale (SBS) and Physical Activity Rating Scale (PARS). The CLPM analysis evaluated bidirectional predictive pathways, with gender-stratified multi-group comparisons. RESULTS: Significant bidirectional negative associations emerged: (1) PA at T1/T2 predicted reduced SB at T2/T3 (beta = -0.14 to -0.26, p < 0.001). (2) SB at T1/T2 predicted decreased PA at T2/T3 (beta = -0.27 to -0.38, p < 0.001). (3) Gender significantly moderated these relationships, with PA conferring stronger protective effects against subsequent SB in males (beta = -0.35 vs. -0.21 for PA-->SB paths). Conversely, SB triggered earlier and more pronounced PA reductions in males (beta = -0.42 vs. -0.29 for SB-->PA paths). CONCLUSIONS: PA and SB demonstrate stable bidirectional negative associations in adolescents, with significant gender divergence. Males exhibit greater resilience to bullying through PA engagement but heightened vulnerability to PA reduction post-victimization. These findings underscore PA-based interventions as promising bullying mitigation strategies, necessitating gender-tailored implementation approaches. FAU - Wang, Kanglin AU - Wang K AUID- ORCID: 0009-0004-6594-232X AD - School of Physical Education, Wuhan University of Technology, Wuhan 430070, China. FAU - Qiu, Fen AU - Qiu F AD - School of Physical Education, Wuhan University of Technology, Wuhan 430070, China. LA - eng GR - 3120600100/the Fundamental Research Funds for the Central Universities/ PT - Journal Article DEP - 20250911 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC12466661 OTO - NOTNLM OT - adolescents OT - cross-lagged panel model OT - gender differences OT - longitudinal study OT - physical activity OT - school bullying COIS- The authors declare no competing interests. EDAT- 2025/09/27 06:34 MHDA- 2025/09/27 06:35 PMCR- 2025/09/11 CRDT- 2025/09/27 01:11 PHST- 2025/07/23 00:00 [received] PHST- 2025/08/27 00:00 [revised] PHST- 2025/09/05 00:00 [accepted] PHST- 2025/09/27 06:35 [medline] PHST- 2025/09/27 06:34 [pubmed] PHST- 2025/09/27 01:11 [entrez] PHST- 2025/09/11 00:00 [pmc-release] AID - bs15091236 [pii] AID - behavsci-15-01236 [pii] AID - 10.3390/bs15091236 [doi] PST - epublish SO - Behav Sci (Basel). 2025 Sep 11;15(9):1236. doi: 10.3390/bs15091236. PMID- 41008492 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250927 LR - 20250930 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 13 IP - 18 DP - 2025 Sep 19 TI - Using Participatory Action Research to Enhance Physical Education Interventions for Promoting Active Lifestyles in Schools: A Study Design and Protocol. LID - 10.3390/healthcare13182362 [doi] LID - 2362 AB - Promoting active lifestyles among adolescents is essential due to their short-, medium-, and long-term contributions to young people's holistic development and overall health. Beyond physical well-being, Physical Education foster physical activity, autonomy, social connectedness, motivation and emotional well-being, thus constituting a key dimension of quality education. BACKGROUND/OBJECTIVES: The "Estilos de Vida Activos (EVA)" project is a school-based intervention designed to foster adolescent agency and motivation in adopting active habits. Grounded in the salutogenic model, self-determination theory, and the health-based Physical Education pedagogical model, this protocol describes the design and implementation strategies of a participatory intervention in secondary schools. METHODS: A variety of research methods will be used to collect quantitative and qualitative data before, during, and after the intervention. Validated questionnaires will assess active commuting, socioeconomic status, satisfaction of basic psychological needs, motivation, levels and intention to engage in physical activity. Qualitative data include interviews with teachers, Photovoice sessions with students, observation notes, and programme materials. INTERVENTION: The EVA intervention is collaboratively developed by students, teachers, and researchers using participatory action research. It includes needs analysis, participatory activities, and co-design of tailored physical activity programmes. The intervention is described using the Template for Intervention Description and Replication checklist (TIDieR) to enhance transparency and replicability. CONCLUSIONS: This protocol presents a theoretically grounded and participatory approach to school-based health promotion. By integrating educational and collaborative strategies, it offers a replicable model that promotes adolescent active lifestyles, from contextual relevance, and pedagogical coherence, serving as a guide for inclusive and sustainable interventions in school settings. FAU - Lizandra, Jorge AU - Lizandra J AUID- ORCID: 0000-0001-5599-133X AD - Department of Teaching Physical Education, Arts and Music, Faculty of Teacher Training, Universitat de Valencia, 46022 Valencia, Spain. FAU - Valencia-Peris, Alexandra AU - Valencia-Peris A AUID- ORCID: 0000-0002-2031-9743 AD - Department of Teaching Physical Education, Arts and Music, Faculty of Teacher Training, Universitat de Valencia, 46022 Valencia, Spain. FAU - Ferriz, Roberto AU - Ferriz R AUID- ORCID: 0000-0001-7041-4098 AD - Department of Teaching Physical Education, Arts and Music, Faculty of Teacher Training, Universitat de Valencia, 46022 Valencia, Spain. FAU - Peiro-Velert, Carmen AU - Peiro-Velert C AUID- ORCID: 0000-0003-4794-6541 AD - Department of Teaching Physical Education, Arts and Music, Faculty of Teacher Training, Universitat de Valencia, 46022 Valencia, Spain. LA - eng GR - BEST/2017/094/Conselleria d'Educacio, Investigacio, Cultura i Esport/ GR - GV/2020/062/Conselleria de Innovacion, Universidades, Ciencia y Sociedad Digital/ PT - Journal Article DEP - 20250919 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12469524 OTO - NOTNLM OT - collaborative methodologies OT - health promotion OT - salutogenic approach OT - self-determination theory OT - youth engagement COIS- The authors declare no conflicts of interest. EDAT- 2025/09/27 06:33 MHDA- 2025/09/27 06:34 PMCR- 2025/09/19 CRDT- 2025/09/27 01:09 PHST- 2025/07/29 00:00 [received] PHST- 2025/09/05 00:00 [revised] PHST- 2025/09/15 00:00 [accepted] PHST- 2025/09/27 06:34 [medline] PHST- 2025/09/27 06:33 [pubmed] PHST- 2025/09/27 01:09 [entrez] PHST- 2025/09/19 00:00 [pmc-release] AID - healthcare13182362 [pii] AID - healthcare-13-02362 [pii] AID - 10.3390/healthcare13182362 [doi] PST - epublish SO - Healthcare (Basel). 2025 Sep 19;13(18):2362. doi: 10.3390/healthcare13182362. PMID- 41008436 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250927 LR - 20250930 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 13 IP - 18 DP - 2025 Sep 15 TI - Physical Activity, Body Mass Index, and Bullying in Higher Education: A Comparative Analysis of Students with and Without Structured Sports Training. LID - 10.3390/healthcare13182304 [doi] LID - 2304 AB - Background/Objectives: Organized physical activity is frequently considered a protective factor against bullying behaviors, yet evidence within the university context remains limited. This study investigates the relationships between physical activity levels, body mass index (BMI), and involvement in traditional and digital bullying, taking into account the differences between students with and without structured sports training. Methods: A total of 2767 first-year students from Transylvania University of Brasov participated. The sports group (n = 161; 65 females, 96 males) was compared to the non-sports group (n = 2606; 1472 females, 1134 males). Instruments included the Physical Activity Questionnaire for Adolescents (PAQ-A), validated scales for traditional and cyberbullying and victimization, and BMI calculation. Statistical analyses involved t-tests (two-tailed), 2 x 2 factorial ANOVA, and sex-stratified multiple linear regressions. Results: Students with sports training reported higher physical activity (PAQ-A 4.2-4.6), lower BMI, and lower bullying involvement (traditional approximately 14-21% vs. approximately 32%; cyber approximately 8-17% vs. approximately 25%). Group differences were large for physical activity (Hedges' g approximately 1.5) and moderate for BMI and bullying (g approximately 0.68-0.96; point-biserial r(2) approximately 3-4%). ANOVA showed sports status main effects (partial eta(p)(2) approximately 4-5% for bullying/BMI; approximately 20% for PAQ-A). In regressions, sports status (B = -0.30 to -0.44) and physical activity (B = -0.22 to -0.32) predicted lower aggression/victimization, whereas BMI showed positive associations (B = 0.11 to 0.18) (all p < 0.001). Sex x sports interactions were significant for PAQ-A and for traditional and cyber-victimization. Conclusions: Structured physical activity contributes to reducing the risk of bullying involvement and supports better psychosocial adjustment among students. These findings underscore the educational and preventive potential of university sports programs. FAU - Mijaica, Raluca AU - Mijaica R AUID- ORCID: 0000-0002-1071-8003 AD - Department of Physical Education and Special Motricity, Faculty of Physical Education and Mountain Sports, Transylvania University of Brasov, 500068 Brasov, Romania. FAU - Balint, Lorand AU - Balint L AUID- ORCID: 0000-0002-2613-5961 AD - Department of Physical Education and Special Motricity, Faculty of Physical Education and Mountain Sports, Transylvania University of Brasov, 500068 Brasov, Romania. LA - eng PT - Journal Article DEP - 20250915 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12469962 OTO - NOTNLM OT - aggression OT - body mass index OT - bullying OT - cyberbullying OT - organized physical activity OT - psychosocial adjustment OT - university students OT - victimization COIS- The authors declare no conflicts of interest. EDAT- 2025/09/27 06:33 MHDA- 2025/09/27 06:34 PMCR- 2025/09/15 CRDT- 2025/09/27 01:08 PHST- 2025/07/30 00:00 [received] PHST- 2025/09/11 00:00 [revised] PHST- 2025/09/12 00:00 [accepted] PHST- 2025/09/27 06:34 [medline] PHST- 2025/09/27 06:33 [pubmed] PHST- 2025/09/27 01:08 [entrez] PHST- 2025/09/15 00:00 [pmc-release] AID - healthcare13182304 [pii] AID - healthcare-13-02304 [pii] AID - 10.3390/healthcare13182304 [doi] PST - epublish SO - Healthcare (Basel). 2025 Sep 15;13(18):2304. doi: 10.3390/healthcare13182304. PMID- 41007603 OWN - NLM STAT- MEDLINE DCOM- 20250927 LR - 20260918 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 22 IP - 9 DP - 2025 Sep 20 TI - Designing, Developing, and Evaluating a Stakeholder-Informed Mobile App to Promote Physical Activity in Children. LID - 10.3390/ijerph22091460 [doi] LID - 1460 AB - Background: Prolonged sedentary behavior and associated obesity are recognized risk factors for poor health across the lifespan. Globally, data show that many children and adolescents aged 5 to 17 significantly increased their sedentary behaviors during the COVID-19 pandemic, failing to meet recommended physical activity levels and reporting increased smartphone use. While mobile devices and video games have been traditionally linked to physical inactivity, formats like exergaming, which combine gameplay with gross motor activity, offer potential to promote physical activity. However, many digital health tools for children are developed without incorporating feedback from key stakeholders and end-users (e.g., children, teachers, and guardians). Therefore, this paper, within the Walk around the Earth (E-Walk) project, describes a prospective study that aims (1) to identify the most influential factors or characteristics affecting engagement with and usability of a mobile application promoting physical activity among primary school students; (2) to develop a mobile application for children based on the identified factors and characteristics. Methods: This project will use a group concept mapping approach to identify the most influential features/factors/characteristics affecting engagement with and usability of an app. By involving primary stakeholders (e.g., children, teachers, guardians, and physical activity experts), the project seeks to align the app's features with primary end-user needs and motivations. Following the app's development, its effectiveness in increasing physical activity levels and reducing sedentary behaviors will be evaluated through a mixed-method design, incorporating anthropometric data, validated physical activity questionnaires (Physical Activity Questionnaire for Older Children (PAQ-C) and International Physical Activity Questionnaire (IPAQ)), and engagement metrics. Conclusions: The E-Walk project integrates participatory design with educational content and activity-based challenges, representing a multidimensional strategy for promoting health and learning in primary school students. Ultimately, this study contributes to the development of user-informed digital interventions that support sustainable behavioral changes, in line with broader goals of child well-being and digital health promotion. FAU - Papale, Olga AU - Papale O AUID- ORCID: 0009-0006-9095-7245 AD - Department of Human Sciences, Society and Heath, University of Cassino and Lazio Meridionale, 03042 Cassino, Italy. AD - European University of Technology EUt+, 03043 Cassino, Italy. FAU - Festino, Emanuel AU - Festino E AUID- ORCID: 0009-0003-7680-7206 AD - Department of Human Sciences, Society and Heath, University of Cassino and Lazio Meridionale, 03042 Cassino, Italy. AD - European University of Technology EUt+, 03043 Cassino, Italy. FAU - Papargyri, Lamprini AU - Papargyri L AD - MindSpin, Nicosia 1678, Cyprus. FAU - Cortis, Cristina AU - Cortis C AUID- ORCID: 0000-0001-9643-5532 AD - Department of Human Sciences, Society and Heath, University of Cassino and Lazio Meridionale, 03042 Cassino, Italy. AD - European University of Technology EUt+, 03043 Cassino, Italy. FAU - Fusco, Andrea AU - Fusco A AUID- ORCID: 0000-0002-9090-4454 AD - Department of Medicine and Aging Sciences, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy. CN - Walk around the Earth Project Team LA - eng GR - 101183970/European Commission ERASMUS+Sport Collaborative Partnerships/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250920 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - *Mobile Applications MH - *Exercise MH - Child MH - *Health Promotion/methods MH - Adolescent MH - COVID-19 MH - Prospective Studies MH - Male MH - Female MH - Sedentary Behavior MH - Stakeholder Participation MH - Child, Preschool PMC - PMC12469936 OTO - NOTNLM OT - group concept mapping OT - health promotion OT - sedentary behaviors OT - walking COIS- Author Lamprini Papargyri is affiliated to MindSpin. The remaining authors declare that the research will be conducted without any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/09/27 06:34 MHDA- 2025/09/27 06:35 PMCR- 2025/09/20 CRDT- 2025/09/27 01:05 PHST- 2025/08/13 00:00 [received] PHST- 2025/09/12 00:00 [revised] PHST- 2025/09/17 00:00 [accepted] PHST- 2025/09/27 06:35 [medline] PHST- 2025/09/27 06:34 [pubmed] PHST- 2025/09/27 01:05 [entrez] PHST- 2025/09/20 00:00 [pmc-release] AID - ijerph22091460 [pii] AID - ijerph-22-01460 [pii] AID - 10.3390/ijerph22091460 [doi] PST - epublish SO - Int J Environ Res Public Health. 2025 Sep 20;22(9):1460. doi: 10.3390/ijerph22091460. PMID- 41007065 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250927 LR - 20250930 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 9 DP - 2025 Sep 8 TI - Weight Status, Psychosocial Factors, and Health-Related Quality of Life Among Jordanian Adolescents: A Cross-Sectional Study Using Structural Equation Modeling. LID - 10.3390/children12091199 [doi] LID - 1199 AB - Background/Objectives: Childhood and adolescent obesity is a growing public health concern in Jordan, with implications for both physical and psychological well-being. While obesity's physical effects are well-documented, less is known about its broader association with adolescents' quality of life (QoL), particularly in Middle Eastern contexts. This study aimed to investigate the associations between weight status, psychosocial factors, and health-related quality of life (HRQOL) among Jordanian adolescents. This study aimed to investigate the associations between weight status, psychosocial factors, and HRQoL among Jordanian adolescents. Methods: A cross-sectional study was conducted with 719 adolescents (63.3% female) aged 11-18, recruited from public schools and pediatric clinics in three regions of Jordan. Data were collected using validated questionnaires assessing demographics, health behaviors, mental health (PHQ-9, GAD-7, SMFQ), and HRQoL (PedsQL 4.0). Structural equation modeling (SEM) was used to examine direct and indirect pathways predicting physical and psychological QoL. Results: Bullying emerged as a key mediator between weight status and QoL, particularly for physical well-being. Depression and anxiety were significant predictors of poorer psychological QoL. Positive school experience, academic performance, physical activity, and paternal education were positively associated with QoL. Nutritional habits were inversely associated with anxiety levels. Model fit indices supported the adequacy of both the physical and psychological QoL models. Conclusions: The findings highlight the interconnected relationship of weight-related stigma, school environment, and lifestyle behaviors on adolescent well-being. Multi-component, school-based interventions targeting bullying, physical activity, and mental health literacy may be effective in improving QoL in this population. FAU - AlQaisi, Randa AU - AlQaisi R AD - Department of Pediatrics, Faculty of Medicine, Mutah University, AlKarak 61710, Jordan. FAU - Al-Qerem, Walid AU - Al-Qerem W AUID- ORCID: 0000-0001-9831-7572 AD - Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan. FAU - Al-Zu'bi, Belal AU - Al-Zu'bi B AUID- ORCID: 0000-0002-7732-421X AD - Department of Special Surgery, Faculty of Medicine, Mutah University, AlKarak 61710, Jordan. FAU - Al-Tah, Basil AU - Al-Tah B AUID- ORCID: 0000-0002-9952-348X AD - Jordan University Hospital, Amman 13046, Jordan. FAU - Daher, Moath H AU - Daher MH AD - Ministry of Health, Amman 11118, Jordan. FAU - I Alfreahat, Mu'taz AU - I Alfreahat M AD - Jordan University Hospital, Amman 13046, Jordan. FAU - Mousa, Nasser A AU - Mousa NA AD - Ministry of Health, Amman 11118, Jordan. FAU - Jankhout, Seif D AU - Jankhout SD AUID- ORCID: 0009-0004-9071-0512 AD - Ministry of Health, Amman 11118, Jordan. FAU - Atrooz, Ansam O AU - Atrooz AO AUID- ORCID: 0009-0001-8458-9603 AD - Alkarak Governmental Hospital, AlKarak 61710, Jordan. FAU - Eberhardt, Judith AU - Eberhardt J AUID- ORCID: 0000-0003-0745-178X AD - Department of Psychology, School of Social Sciences, Humanities and Law, Teesside University, Borough Road, Middlesbrough TS1 3BX, UK. LA - eng PT - Journal Article DEP - 20250908 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12468896 OTO - NOTNLM OT - SEM OT - adolescents OT - bullying OT - mental health OT - obesity OT - physical activity OT - quality of life COIS- The authors declare no conflicts of interest. EDAT- 2025/09/27 06:33 MHDA- 2025/09/27 06:34 PMCR- 2025/09/08 CRDT- 2025/09/27 01:03 PHST- 2025/05/15 00:00 [received] PHST- 2025/06/20 00:00 [revised] PHST- 2025/09/03 00:00 [accepted] PHST- 2025/09/27 06:34 [medline] PHST- 2025/09/27 06:33 [pubmed] PHST- 2025/09/27 01:03 [entrez] PHST- 2025/09/08 00:00 [pmc-release] AID - children12091199 [pii] AID - children-12-01199 [pii] AID - 10.3390/children12091199 [doi] PST - epublish SO - Children (Basel). 2025 Sep 8;12(9):1199. doi: 10.3390/children12091199. PMID- 41006885 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20261008 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) VI - 99 IP - 7 DP - 2026 Jun TI - Positive association between visceral adiposity index and asthma in US children and adolescents: an analysis of NHANES data. PG - 2598-2604 LID - 10.1038/s41390-025-04453-8 [doi] AB - BACKGROUND: Asthma represents an inflammatory condition. The exact function of VAI in asthma among children and adolescents is still not well understood. METHODS: A cross-sectional investigation was carried out by utilizing data sourced from 7814 children and adolescents participating in the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2020. It adjusted for covariates and employed techniques such as multivariate logistic regression, restricted cubic spline modeling, and subgroup analyses. RESULTS: Of the 7814 participants, 1453 (18.6%) had a self-reported asthma diagnosis by a healthcare provider. After multivariate adjustment, higher visceral adiposity index (VAI) quartiles showed a dose-dependent increase in asthma risk compared to the lowest quartile (Q1): OR = 1.06 (Q2), 1.18 (Q3), and 1.26 (Q4; 95% CI: 1.05-1.51, p = 0.014). The restricted cubic spline regression demonstrated linearity. Stratified analyses showed no significant interaction between subgroups. CONCLUSIONS: Elevated VAI levels are independently linked to a higher prevalence of asthma among US children and adolescents. IMPACT: Key message: Elevated visceral adiposity index (VAI) is independently associated with increased asthma prevalence in US children and adolescents, revealing a dose-dependent relationship. Novelty to literature: This study establishes a nationally representative, large-scale epidemiological link between VAI (a validated biomarker of visceral fat dysfunction) and pediatric asthma using NHANES data (N = 7814). It advances prior obesity-asthma research by quantifying how visceral adiposity-rather than general obesity-drives risk. Clinical/public health impact: Our findings propose VAI as a potential screening tool for asthma risk stratification. This could inform targeted interventions (e.g., metabolic health optimization) to mitigate asthma burden in pediatric populations. CI - (c) 2025. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - Shao, Shihui AU - Shao S AD - Department of Pediatrics, Binhaiwan Central Hospital of Dongguan, Dongguan, China. FAU - Wu, Longliang AU - Wu L AD - Department of Pediatrics, Binhaiwan Central Hospital of Dongguan, Dongguan, China. FAU - Cui, Caiping AU - Cui C AD - Department of Pediatrics, Binhaiwan Central Hospital of Dongguan, Dongguan, China. FAU - Qin, Zhiyao AU - Qin Z AD - Department of Pediatrics, Binhaiwan Central Hospital of Dongguan, Dongguan, China. FAU - Liang, Yinhua AU - Liang Y AD - Department of Pediatrics, Binhaiwan Central Hospital of Dongguan, Dongguan, China. FAU - Huang, Jiangying AU - Huang J AD - Department of Pediatrics, Binhaiwan Central Hospital of Dongguan, Dongguan, China. FAU - Li, Wei AU - Li W AD - Department of Neonatal, Binhaiwan Central Hospital of Dongguan, Dongguan, China. liweivg@126.com. LA - eng PT - Journal Article DEP - 20250926 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM MH - Humans MH - Adolescent MH - Child MH - *Asthma/epidemiology/physiopathology/diagnosis MH - Female MH - Nutrition Surveys MH - Male MH - Cross-Sectional Studies MH - United States/epidemiology MH - *Adiposity MH - *Intra-Abdominal Fat/physiopathology MH - Prevalence MH - Risk Factors MH - *Obesity, Abdominal/epidemiology/physiopathology/complications COIS- Competing interests: The authors declare no competing interests. EDAT- 2025/09/27 06:33 MHDA- 2026/08/19 14:49 CRDT- 2025/09/27 00:13 PHST- 2025/05/19 00:00 [received] PHST- 2025/08/17 00:00 [accepted] PHST- 2025/08/11 00:00 [revised] PHST- 2026/08/19 14:49 [medline] PHST- 2025/09/27 06:33 [pubmed] PHST- 2025/09/27 00:13 [entrez] AID - 10.1038/s41390-025-04453-8 [pii] AID - 10.1038/s41390-025-04453-8 [doi] PST - ppublish SO - Pediatr Res. 2026 Jun;99(7):2598-2604. doi: 10.1038/s41390-025-04453-8. Epub 2025 Sep 26. PMID- 41005786 OWN - NLM STAT- MEDLINE DCOM- 20250926 LR - 20251002 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 9 DP - 2025 Sep 26 TI - Can ultrasound echo intensity assess muscle quality in children aged 10-14 years? Protocol for a cross-sectional validation study in Czech children. PG - e100495 LID - 10.1136/bmjopen-2025-100495 [doi] LID - e100495 AB - INTRODUCTION: Ultrasonography is a non-invasive and safe method for assessing muscle morphology. Among its parameters, echo intensity (EI), derived from grayscale image analysis, has emerged as a promising indicator of muscle quality and intramuscular fat infiltration. This study aims to validate EI as a marker for evaluating muscle quality in a population of Czech children, through integration with gold-standard assessments of muscle strength and body composition. The primary aim of this study is to assess the reliability and construct validity of quadriceps muscle EI using ultrasound as a proxy measure of morphological muscle quality in children aged 10-14 years. METHODS AND ANALYSIS: Children aged 10-14 years will undergo ultrasound assessment of the quadriceps femoris (QF). EI will be derived from longitudinal scans of each QF head and the cross-sectional area (CSA(QF)) from panoramic mid-thigh images. Muscle function will be assessed as maximal voluntary contraction (MVC) of isometric knee extension with muscle quality expressed as MVC/CSA(QF). A 30 s sit-to-stand test (30STS) will be used as an additional functional measure. EI reliability (intra-rater, inter-rater and test-retest) will be evaluated with intraclass correlation coefficients (ICC), Bland-Altman plots and complementary indices. Exploratory known-groups validity will be tested by comparing EI between weight-status groups. Control variables include dual-energy X-ray absorptiometry (DXA)-derived body composition, skeletal age (as determined by DXA hand scans) and physical activity (assessed using 7-day accelerometry).This study will include 200 children (100 girls and 100 boys) aged 10-14 years using an a priori power analysis based on the primary objective of assessing construct validity through multiple linear regression, assuming an alpha level of 0.05 and 80% power. Participants will be recruited from paediatric outpatients of the Paediatric Obesity Clinic and individuals reached through a recruitment campaign. Inclusion criteria require general good health, while exclusion criteria include a history or symptoms of cardiovascular, pulmonary, metabolic or neurological disease, as well as the use of over-the-counter or prescribed medications. Informed consent and assent will be obtained from all participants.Reliability of ultrasound-derived EI will be assessed for intra-rater, inter-rater and test-retest agreement using ICC coefficients, Bland-Altman plots and complementary indices such as SE of measurement, coefficient of variation and minimal detectable change at 95% CI, following Consensus-based Standards for the selection of health Measurement Instruments guidelines. Construct validity will be examined by modelling associations between EI and functional muscle quality (MVC/CSA(QF)), with 30STS as an additional functional measure. Known-groups validity will be tested by comparing EI across weight groups, using generalised linear regression models adjusted for skeletal age, body composition and physical activity. All validity analyses will be conducted separately for girls and boys. Ultrasound-derived EI of the QF is expected to show high reliability (ICC>/=0.80) and acceptable test-retest reproducibility. Construct validity should be supported by moderate associations with functional muscle quality (MVC/CSA(QF)), while known-groups validity is expected to reveal higher EI values in children with obesity and/or insufficient physical activity. ETHICS AND DISSEMINATION: The study will be conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of the Faculty of Physical Education and Sport, Charles University (EK 101/2024). Written parental consent and verbal assent from children will be obtained, with all data handled confidentially and anonymised. Results will be disseminated transparently to participants and their families in line with ethical principles of respect, beneficence and justice. TRIAL REGISTRATION NUMBER: NCT06792279. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Jandova, Tereza AU - Jandova T AUID- ORCID: 0000-0002-5603-5670 AD - Charles University, Faculty of Physical Education and Sport, Prague, Czech Republic. FAU - Kinkorova, Ivana AU - Kinkorova I AD - Charles University, Faculty of Physical Education and Sport, Prague, Czech Republic. FAU - Vetrovsky, Tomas AU - Vetrovsky T AD - Charles University, Faculty of Physical Education and Sport, Prague, Czech Republic. FAU - Mala, Jitka AU - Mala J AD - Charles University, Faculty of Physical Education and Sport, Prague, Czech Republic. FAU - Musilova, Evelyn AU - Musilova E AD - Charles University, Faculty of Physical Education and Sport, Prague, Czech Republic. FAU - Steffl, Michal AU - Steffl M AUID- ORCID: 0000-0001-7297-8145 AD - Charles University, Faculty of Physical Education and Sport, Prague, Czech Republic steffl@ftvs.cuni.cz. FAU - Narici, Marco V AU - Narici MV AD - University of Padua School of Medicine and Surgery, Padua, Veneto, Italy. LA - eng SI - ClinicalTrials.gov/NCT06792279 PT - Clinical Trial Protocol PT - Journal Article DEP - 20250926 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Body Composition MH - Cross-Sectional Studies MH - Czech Republic MH - *Muscle Strength/physiology MH - *Quadriceps Muscle/diagnostic imaging/physiology MH - Reproducibility of Results MH - Research Design MH - Ultrasonography/methods MH - Validation Studies as Topic MH - Observational Studies as Topic PMC - PMC12481363 OTO - NOTNLM OT - Child OT - Obesity OT - Ultrasound COIS- Competing interests: None declared. EDAT- 2025/09/27 00:30 MHDA- 2025/09/27 00:31 PMCR- 2025/09/26 CRDT- 2025/09/26 20:43 PHST- 2025/09/27 00:31 [medline] PHST- 2025/09/27 00:30 [pubmed] PHST- 2025/09/26 20:43 [entrez] PHST- 2025/09/26 00:00 [pmc-release] AID - bmjopen-2025-100495 [pii] AID - 10.1136/bmjopen-2025-100495 [doi] PST - epublish SO - BMJ Open. 2025 Sep 26;15(9):e100495. doi: 10.1136/bmjopen-2025-100495. PMID- 41005489 OWN - NLM STAT- MEDLINE DCOM- 20260111 LR - 20260511 IS - 1876-2867 (Electronic) IS - 1876-2859 (Linking) VI - 26 IP - 1 DP - 2026 Jan-Feb TI - Impact of a Before-School Physical Activity Program on Children's Subjective Well-Being: Secondary Findings From the Active-Start Study. PG - 103151 LID - S1876-2859(25)00376-6 [pii] LID - 10.1016/j.acap.2025.103151 [doi] AB - OBJECTIVE: The aim of the study was to test a before-school physical activity intervention (Active-Start) on subjective well-being in socioeconomically disadvantaged Chilean children. METHOD: The Active-Start intervention was a randomized controlled trial involving 170 children aged 8 to 10 from 3 highly vulnerable public schools in Santiago (Chile). The physical activity intervention was delivered daily, before starting the first school-class (8:00-8:30 a.m.) for 8 weeks. Subjective well-being was assessed using validated instruments: the CUBE scale for life satisfaction and a 10-item affect scale for positive and negative emotions. The analyses used were generalized linear mixed models. RESULTS: The intervention significantly increased positive emotions in boys (B=0.56, 95% confidence intervals [CI] 0.13 to 0.99, P=.011) and girls (B=0.25, 95% CI 0.02 to 0.48, P=.044). Boys also showed an improvement in overall subjective well-being (z-score: B=1.05, 95% CI 0.05 to 2.15, P=.041). Specifically, boys reported higher levels of happiness (B=0.58, 95% CI 0.14 to 1.02, P=.031), contentment (B=0.69, 95% CI 0.16 to 1.22, P=.012), and fun (B=0.89, 95% CI 0.31 to 1.47, P=.003). In contrast, changes in life satisfaction and negative emotions were not significant for either sex. CONCLUSIONS: Our findings suggest that engaging in morning physical activity before starting classes increases positive emotions (such as happiness, contentment, and fun) in children from socioeconomically disadvantaged backgrounds, particularly among boys. This improvement in emotional well-being could enhance their mood and readiness for learning. CI - Copyright (c) 2025 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved. FAU - Garcia-Hermoso, Antonio AU - Garcia-Hermoso A AD - Navarrabiomed (A Garcia-Hermoso, I Hormazabal-Aguayo, and J Munoz-Pardeza), Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), IdiSNA, Pamplona, Spain. Electronic address: antonio.garciah@unavarra.es. FAU - Hormazabal-Aguayo, Ignacio AU - Hormazabal-Aguayo I AD - Navarrabiomed (A Garcia-Hermoso, I Hormazabal-Aguayo, and J Munoz-Pardeza), Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), IdiSNA, Pamplona, Spain; Vicerrectoria de Investigacion y Postgrado (I Hormazabal-Aguayo), Universidad de La Serena, Chile. FAU - Munoz-Pardeza, Jacinto AU - Munoz-Pardeza J AD - Navarrabiomed (A Garcia-Hermoso, I Hormazabal-Aguayo, and J Munoz-Pardeza), Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), IdiSNA, Pamplona, Spain. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AD - School of Medicine (JF Lopez-Gil), Universidad Espiritu Santo, Samborondon, Ecuador; Department of Communication and Education (JF Lopez-Gil), Universidad Loyola Andalucia, Sevilla, Spain. FAU - Yanez-Sepulveda, Rodrigo AU - Yanez-Sepulveda R AD - Faculty of Education and Social Sciences (R Yanez-Sepulveda), Universidad Andres Bello, Vina del Mar, Chile. FAU - Paez-Herrera, Jacqueline AU - Paez-Herrera J AD - Grupo Investigacion Efidac (J Paez-Herrera). Escuela Educacion Fisica. Pontificia Universidad Catolica de Valparaiso, Chile. FAU - Ezzatvar, Yasmin AU - Ezzatvar Y AD - Lifestyle factors with impact on Ageing and overall Health (LAH) Research Group. Department of Nursing (Y Ezzatvar), University of Valencia, Spain; Vicerrectoria de Investigacion y Postgrado (Y Ezzatvar), Universidad de Los Lagos, Osorno, Chile. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20250924 PL - United States TA - Acad Pediatr JT - Academic pediatrics JID - 101499145 SB - IM MH - Humans MH - Male MH - Female MH - Child MH - Chile MH - *Personal Satisfaction MH - *Exercise/psychology MH - Happiness MH - *Emotions MH - Schools MH - *Health Promotion/methods MH - Sex Factors MH - Linear Models OTO - NOTNLM OT - Life satisfaction OT - Negative emotions OT - Positive emotions OT - School-based exercise COIS- Declaration of Competing Interest The authors have no conflict of interest to declare. EDAT- 2025/09/27 00:30 MHDA- 2026/01/12 00:37 CRDT- 2025/09/26 19:36 PHST- 2025/03/25 00:00 [received] PHST- 2025/08/14 00:00 [revised] PHST- 2025/08/27 00:00 [accepted] PHST- 2026/01/12 00:37 [medline] PHST- 2025/09/27 00:30 [pubmed] PHST- 2025/09/26 19:36 [entrez] AID - S1876-2859(25)00376-6 [pii] AID - 10.1016/j.acap.2025.103151 [doi] PST - ppublish SO - Acad Pediatr. 2026 Jan-Feb;26(1):103151. doi: 10.1016/j.acap.2025.103151. Epub 2025 Sep 24. PMID- 41005132 OWN - NLM STAT- MEDLINE DCOM- 20260309 LR - 20260309 IS - 1532-3099 (Electronic) IS - 0266-6138 (Linking) VI - 150 DP - 2025 Nov TI - Development and preliminary testing of a scenario-based instrument to measure nutrition literacy of pregnant women. PG - 104613 LID - S0266-6138(25)00330-4 [pii] LID - 10.1016/j.midw.2025.104613 [doi] AB - BACKGROUND: Nutrition literacy (NL) during pregnancy is important for both mothers and infants. The present study aimed to develop a scenario-based instrument to measure the NL abilities of pregnant women and test the validity and reliability of this instrument. METHODS: The development of the instrument comprised six phases: (1) identification of key domains through literature review; (2) a Delphi survey; (3) development of a scenario-based test; (4) evaluation of content validity; (5) pilot test; and (6) assessment of the instrument's psychometric properties. RESULTS: A convenience sample of 489 pregnant Taiwanese women was used to assess NL via a 22-item scenario-based scale across four domains: "understand", "analyse", "appraise", and "apply". Item Response Theory analysis showed that most items provided the greatest precision for respondents with low to moderate ability levels (theta = -3 to 0). Confirmatory factor analysis supported a second-order, four-factor model. Internal consistency was acceptable (Cronbach's alpha = 0.78), and item-total correlations ranged from 0.31 to 0.53 (p < 0.001), indicating strong reliability. CONCLUSION: The validated Nutrition Literacy Scale is psychometrically sound and suitable for research, clinical use, and future interventions to improve NL and dietary behaviours during pregnancy. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - Chen, Tzu-Ling AU - Chen TL AD - Department of Nurse-Midwifery and Women's Health, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan. Electronic address: tzuling@ntunhs.edu.tw. FAU - Liao, Li-Ling AU - Liao LL AD - Department of Public Health, College of Health Science, Kaohsiung Medical University, Kaohsiung City, Taiwan. Electronic address: liling@kmu.edu.tw. FAU - Wei, Mi-Hsiu AU - Wei MH AD - Department of Communication Studies, Tzu Chi University, Hualien City, Taiwan. Electronic address: michelle@mail.tcu.edu.tw. FAU - Fang, Yueh-Yin AU - Fang YY AD - Nurse Practitioner, Obstetrician and Gynecologist, Department of Obstetrics and Gynecology, Cheng-Hsin General Hospital, Taipei, Taiwan. FAU - Wu, Chia-Hsun AU - Wu CH AD - Obstetrician and gynecologist, Department of Obstetrics and Gynecology, Cheng-Hsin General Hospital, Taipei, Taiwan. Electronic address: ntunhschenghsin@gmail.com. LA - eng PT - Journal Article DEP - 20250917 PL - Scotland TA - Midwifery JT - Midwifery JID - 8510930 SB - IM MH - Adult MH - Female MH - Humans MH - Pregnancy MH - Young Adult MH - *Diet, Healthy MH - *Health Knowledge, Attitudes, Practice MH - *Health Literacy MH - *Prenatal Nutritional Physiological Phenomena MH - *Psychometrics MH - Reproducibility of Results MH - Surveys and Questionnaires MH - Delphi Technique OTO - NOTNLM OT - Confirmatory factor analysis OT - Item response theory OT - Nutrient literacy OT - Pregnant women OT - Validation COIS- Declaration of competing interest All authors are without conflicts of interest, including specific financial interests and relationships and affiliations relevant to the subject of their manuscript. EDAT- 2025/09/27 00:30 MHDA- 2025/10/26 00:32 CRDT- 2025/09/26 18:09 PHST- 2025/05/01 00:00 [received] PHST- 2025/09/12 00:00 [revised] PHST- 2025/09/16 00:00 [accepted] PHST- 2025/10/26 00:32 [medline] PHST- 2025/09/27 00:30 [pubmed] PHST- 2025/09/26 18:09 [entrez] AID - S0266-6138(25)00330-4 [pii] AID - 10.1016/j.midw.2025.104613 [doi] PST - ppublish SO - Midwifery. 2025 Nov;150:104613. doi: 10.1016/j.midw.2025.104613. Epub 2025 Sep 17. PMID- 41004657 OWN - NLM STAT- MEDLINE DCOM- 20260309 LR - 20260309 IS - 1878-6324 (Electronic) IS - 1053-8127 (Linking) VI - 39 IP - 2 DP - 2026 Mar TI - Musculoskeletal pain and psychological flourishing among Saudi male gamers: The role of physical activity and gaming status. PG - 467-476 LID - 10.1177/10538127251381072 [doi] AB - BackgroundGamers are increasingly at risk for musculoskeletal (MSK) pain due to prolonged screen exposure and poor posture. However, the relationship between MSK pain and psychological flourishing remains underexplored.ObjectiveTo (1) assess the prevalence and distribution of upper body and back MSK pain among Saudi gamers, (2) examine the effects of age, gaming status, physical activity, and gaming exposure on pain prevalence, and (3) explore the association between MSK pain and psychological flourishing.MethodsA cross-sectional survey was conducted among 428 male gamers in Saudi Arabia, categorized as professional or casual. Validated instruments assessed MSK pain (Extended Nordic Musculoskeletal Questionnaire), physical activity levels, gaming patterns, and flourishing (Flourishing Scale). Statistical analyses included chi-square tests, Mann-Whitney U tests, binary logistic regression, and a bootstrapped Generalized Linear Model (GLM).ResultsMSK pain affected 71.0% of participants, with the neck and lower back most commonly reported. Casual gamers had significantly higher pain prevalence than professionals. Vigorous physical activity was associated with lower odds of neck and shoulder pain. Binary logistic regression identified physical activity as the only consistent predictor of reduced pain, while gaming exposure and age were not significant. No significant association was found between MSK pain and psychological flourishing in bivariate or multivariable models.ConclusionMSK pain is common among Saudi gamers, particularly casual players. Regular physical activity may reduce pain risk and should be encouraged among gamers. Psychological flourishing appeared unaffected by MSK pain or gaming status, suggesting other factors may influence well-being in this population. FAU - Alqabbani, Samiah AU - Alqabbani S AUID- ORCID: 0000-0003-4495-5047 AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. LA - eng PT - Journal Article DEP - 20250926 PL - United States TA - J Back Musculoskelet Rehabil JT - Journal of back and musculoskeletal rehabilitation JID - 9201340 SB - IM MH - Humans MH - Male MH - Saudi Arabia/epidemiology MH - Cross-Sectional Studies MH - *Musculoskeletal Pain/epidemiology/psychology MH - *Exercise MH - Adult MH - Young Adult MH - *Video Games/adverse effects/psychology MH - Prevalence MH - Adolescent MH - Surveys and Questionnaires OTO - NOTNLM OT - Saudi Arabia OT - ergonomics OT - flourishing OT - gamers OT - gaming exposure OT - musculoskeletal pain OT - physical activity COIS- Declaration of conflicting interestsThe author declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/09/26 18:30 MHDA- 2026/03/09 13:42 CRDT- 2025/09/26 15:13 PHST- 2026/03/09 13:42 [medline] PHST- 2025/09/26 18:30 [pubmed] PHST- 2025/09/26 15:13 [entrez] AID - 10.1177/10538127251381072 [doi] PST - ppublish SO - J Back Musculoskelet Rehabil. 2026 Mar;39(2):467-476. doi: 10.1177/10538127251381072. Epub 2025 Sep 26. PMID- 41001684 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250926 LR - 20250928 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 7 DP - 2025 TI - Changes in cortical brain activity after active break in preschoolers: MOVI-HIIT study. PG - 1529288 LID - 10.3389/fspor.2025.1529288 [doi] LID - 1529288 AB - INTRODUCTION: This study investigates the acute effects of high-intensity interval exercise on brain activity in preschool children, focusing on changes in electroencephalogram (EEG) bands before, immediately after, and 20 min post-exercise. METHODS: Eleven children (5-6 years) participated, but EEG recordings were included only if all channels maintained a quality score >3 (0-4 scale updated every 0.5 s), resulting in the exclusion of two participants due to insufficient high-quality data. RESULTS: EEG data revealing significant increases in Theta, Alpha1, and Alpha2 bands, suggesting enhanced relaxation, attentiveness, and readiness to learn. Conversely, Beta and Gamma bands showed reductions, especially in frontal, temporal, and parietal regions, indicating decreased stress and mental effort. DISCUSSION: These effects persisted for up to 20 min after exercise, suggesting that brief, high-intensity exercise induces EEG changes associated with states of attentional readiness and emotional regulation, which may support learning, pending further validation. CI - (c) 2025 Valdivieso-Gonzalez, Sancho-Bielsa, Garcia-Martinez, Martinez-Rodrigo, Navarro-Martinez, Redondo-Tebar and Sanchez-Lopez. FAU - Valdivieso-Gonzalez, Maria AU - Valdivieso-Gonzalez M AD - Faculty of Education, University of Castilla-La Mancha, Ciudad Real, Spain. AD - Centro de Estudios Sociosanitarios (CESS), University of Castilla-La Mancha, Cuenca, Spain. FAU - Sancho-Bielsa, Francisco Javier AU - Sancho-Bielsa FJ AD - Faculty of Medicine, University of Castilla-La Mancha, Ciudad Real, Spain. FAU - Garcia-Martinez, Beatriz AU - Garcia-Martinez B AD - Polytechnic School of Cuenca, University of Castilla-La Mancha, Cuenca, Spain. FAU - Martinez-Rodrigo, Arturo AU - Martinez-Rodrigo A AD - Research Group in Medical Computing, E-health and Advanced Technologies (COMETA Research Group), Universidad de Castilla La Mancha (UCLM), Cuenca, Spain. FAU - Navarro-Martinez, Oscar AU - Navarro-Martinez O AD - Faculty of Education, University of Castilla-La Mancha, Ciudad Real, Spain. FAU - Redondo-Tebar, Andres AU - Redondo-Tebar A AD - Centro de Estudios Sociosanitarios (CESS), University of Castilla-La Mancha, Cuenca, Spain. AD - Faculty of Nursing, University of Castilla-La Mancha, Ciudad Real, Spain. FAU - Sanchez-Lopez, Mairena AU - Sanchez-Lopez M AD - Faculty of Education, University of Castilla-La Mancha, Ciudad Real, Spain. AD - Centro de Estudios Sociosanitarios (CESS), University of Castilla-La Mancha, Cuenca, Spain. LA - eng PT - Journal Article DEP - 20250910 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC12459121 OTO - NOTNLM OT - acute effect OT - brain waves OT - children OT - electroencephalography OT - physical activity COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/09/26 12:10 MHDA- 2025/09/26 06:32 PMCR- 2025/09/10 CRDT- 2025/09/26 05:48 PHST- 2024/11/16 00:00 [received] PHST- 2025/07/24 00:00 [accepted] PHST- 2025/09/26 06:32 [medline] PHST- 2025/09/26 12:10 [pubmed] PHST- 2025/09/26 05:48 [entrez] PHST- 2025/09/10 00:00 [pmc-release] AID - 10.3389/fspor.2025.1529288 [doi] PST - epublish SO - Front Sports Act Living. 2025 Sep 10;7:1529288. doi: 10.3389/fspor.2025.1529288. eCollection 2025. PMID- 40999694 OWN - NLM STAT- MEDLINE DCOM- 20260102 LR - 20260108 IS - 1475-2662 (Electronic) IS - 0007-1145 (Print) IS - 0007-1145 (Linking) VI - 134 IP - 9 DP - 2025 Nov 14 TI - Validation of a screener to assess ultra-processed food consumption in the adult Indian population: the Nova-UPF Screener (for India). PG - 743-754 LID - 10.1017/S0007114525105230 [doi] AB - Increasing prevalence of diet-related non-communicable diseases in India is attributed to overconsumption of energy-dense, nutrient-poor diets and ultra processed foods (UPF) may potentially contribute to this consumption pattern. Applying standard UPF definition and developing appropriate tools can better capture its consumption among Indians. This cross-sectional study aimed to validate the 'Nova-UPF Screener (for India)' and explore its potential to objectively capture UPF consumption among Indian adults. The screener, adapted in prior formative research study from a tool for Brazilian population, was subjected to content, face and concurrent criterion validation. Subject matter experts (n 74) participated in online consultations to determine its content validity. Adults (18-60 years) from different geographical regions of India were included for face (n 70) and concurrent criterion (n 304) validations. The screener comprised twenty-four UPF categories specific to Indian food environment. Critical inputs from experts on screener's appropriateness were incorporated to enhance its content. For face validation, overall percentage agreement of 99.4 % for all questions indicated a strong agreement for retaining screener attributes in each question. Half the participants (49.4 %) who were administered the finalised screener had Nova-UPF scores between 2 and 4 out of 24. There was almost perfect agreement (Pabak index = 0.85) between distribution of participants based on Nova-UPF scores and fifths of dietary share of UPF (as energy %) assessed by 24-h dietary recall. Nova-UPF Screener (for India) is a valid tool to capture UPF consumption in India that can be used for rapid assessment of UPF consumption and informing policies to improve Indian diets. FAU - Ghosh-Jerath, Suparna AU - Ghosh-Jerath S AUID- ORCID: 0000-0002-2229-4455 AD - The George Institute for Global Healthhttps://ror.org/03s4x4e93, New Delhi, India. FAU - Mediratta, Srishti AU - Mediratta S AUID- ORCID: 0000-0002-6978-4443 AD - Lady Irwin College, University of Delhi, New Delhi, India. FAU - Kumar, Gaurika AU - Kumar G AD - The George Institute for Global Healthhttps://ror.org/03s4x4e93, New Delhi, India. FAU - Kohli, Sahiba AU - Kohli S AUID- ORCID: 0000-0003-4281-6772 AD - The George Institute for Global Healthhttps://ror.org/03s4x4e93, New Delhi, India. FAU - Marrocos-Leite, Fernanda H AU - Marrocos-Leite FH AD - Center for Epidemiological Research in Nutrition and Health, Faculty of Public Health, University of Sao Paulo, Sao Paulo, Brazil. FAU - Khandpur, Neha AU - Khandpur N AD - Wageningen University, Wageningen, the Netherlands. FAU - Reddy, K Srinath AU - Reddy KS AD - Public Health Foundation of India, New Delhi, India. LA - eng GR - INV-002962/GATES/Gates Foundation/United States PT - Journal Article PT - Validation Study DEP - 20250926 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM MH - Humans MH - India MH - Adult MH - *Fast Foods MH - Male MH - Cross-Sectional Studies MH - Middle Aged MH - Female MH - Young Adult MH - *Diet MH - Adolescent MH - *Diet Surveys/methods MH - Reproducibility of Results MH - *Feeding Behavior MH - Surveys and Questionnaires MH - Nutrition Assessment MH - Food, Processed PMC - PMC12766108 OTO - NOTNLM OT - Burden of diet-related non-communicable diseases OT - Dietary assessment tool OT - Food consumption OT - India OT - Nova classification OT - Nutrition surveys OT - Tool adaptation OT - Ultra-processed foods OT - Validation study EDAT- 2025/09/26 06:31 MHDA- 2026/01/02 13:09 PMCR- 2026/01/05 CRDT- 2025/09/26 01:43 PHST- 2026/01/02 13:09 [medline] PHST- 2025/09/26 06:31 [pubmed] PHST- 2025/09/26 01:43 [entrez] PHST- 2026/01/05 00:00 [pmc-release] AID - S0007114525105230 [pii] AID - 10.1017/S0007114525105230 [doi] PST - ppublish SO - Br J Nutr. 2025 Nov 14;134(9):743-754. doi: 10.1017/S0007114525105230. Epub 2025 Sep 26. PMID- 40999482 OWN - NLM STAT- MEDLINE DCOM- 20250926 LR - 20250928 IS - 2047-783X (Electronic) IS - 0949-2321 (Print) IS - 0949-2321 (Linking) VI - 30 IP - 1 DP - 2025 Sep 25 TI - Association between uric acid to high-density lipoprotein cholesterol ratio (UHR) and female infertility: insights from a cross-sectional study. PG - 854 LID - 10.1186/s40001-025-03084-3 [doi] LID - 854 AB - BACKGROUND: Infertility in women of reproductive age is a major worldwide health problem. Oxidative stress, inflammatory responses, and dysregulation of lipid metabolism are among the factors that contribute to female infertility. The ratio of serum uric acid to high-density lipoprotein cholesterol (UHR), a novel composite biomarker that reflects oxidative stress and lipid metabolism, has not been extensively studied in relation to female infertility. This study aims to explore the associations between UHR levels and female infertility. METHODS: This cross-sectional study focused on females aged 18-44 years in the National Health and Nutrition Examination Survey from 2013 to 2018. The association between UHR and infertility was assessed by weighted multivariable logistic regression. Restricted cubic spline (RCS) analysis was employed to analyze the presence of nonlinear relationships between UHR and infertility. Stratified analyses were conducted to investigate the interactions between UHR and infertility in subgroups. RESULTS: Of the included 3087 women, 357 (11.56%) were recognized with infertility. When UHR was continuous, elevated UHR levels showed a positive association with infertility risk after comprehensive adjustment for confounding factors [odds ratio (OR) = 1.07, 95% confidence interval (CI): 1.02-1.12]. Compared with the lowest UHR level (UHR 10.49) had higher odds of infertility (OR = 1.80, 95% CI: 1.03-3.14). A linear relationship was found between UHR and infertility in the RCS analysis. Stratified analyses did not discover any interactions between UHR and infertility in selected subgroups, including age group, educational level, body mass index category, marital status, diabetes, hypertension, hyperlipidemia, and menstrual cycle regularity (all p values for interaction were > 0.05). CONCLUSIONS: The findings demonstrated significant linear associations between elevated UHR levels and increased odds of female infertility. UHR may serve as a potential biomarker for infertility that requires validation. Future studies should remedy the cross-sectional limitations of this study. CI - (c) 2025. The Author(s). FAU - Wang, Jingyang AU - Wang J AD - Department of Obstetrics and Gynecology, Aerospace Center Hospital. , No. 15 Yuquan Road, Haidian District, Beijing, 100049, China. FAU - Wang, Ye AU - Wang Y AD - Department of Obstetrics and Gynecology, Aerospace Center Hospital. , No. 15 Yuquan Road, Haidian District, Beijing, 100049, China. FAU - Niu, Yue AU - Niu Y AD - Department of Obstetrics and Gynecology, Aerospace Center Hospital. , No. 15 Yuquan Road, Haidian District, Beijing, 100049, China. FAU - Wang, Jingzhi AU - Wang J AD - Department of Obstetrics and Gynecology, Aerospace Center Hospital. , No. 15 Yuquan Road, Haidian District, Beijing, 100049, China. FAU - Shi, Lianyao AU - Shi L AD - Department of Obstetrics and Gynecology, Aerospace Center Hospital. , No. 15 Yuquan Road, Haidian District, Beijing, 100049, China. FAU - Guo, Yanjun AU - Guo Y AD - Department of Obstetrics and Gynecology, Aerospace Center Hospital. , No. 15 Yuquan Road, Haidian District, Beijing, 100049, China. FAU - Zhang, Yuyuan AU - Zhang Y AD - Department of Obstetrics and Gynecology, Aerospace Center Hospital. , No. 15 Yuquan Road, Haidian District, Beijing, 100049, China. FAU - Zhou, Xin AU - Zhou X AD - Department of Obstetrics and Gynecology, Aerospace Center Hospital. , No. 15 Yuquan Road, Haidian District, Beijing, 100049, China. FAU - Song, Shufang AU - Song S AD - Department of Obstetrics and Gynecology, Aerospace Center Hospital. , No. 15 Yuquan Road, Haidian District, Beijing, 100049, China. ssf43@sohu.com. LA - eng PT - Journal Article DEP - 20250925 PL - England TA - Eur J Med Res JT - European journal of medical research JID - 9517857 RN - 268B43MJ25 (Uric Acid) RN - 0 (Cholesterol, HDL) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Adult MH - *Infertility, Female/blood/epidemiology MH - *Uric Acid/blood MH - *Cholesterol, HDL/blood MH - Young Adult MH - Biomarkers/blood MH - Adolescent MH - Nutrition Surveys MH - Risk Factors PMC - PMC12465579 OTO - NOTNLM OT - Cross-sectional study OT - High-density lipoprotein cholesterol OT - Infertility OT - UHR index OT - Uric acid COIS- Declarations. Ethics approval and consent to participate: The survey protocols had received ethical approval from the NCHS Ethics Review Board (Protocol #2018-01 and #2011-17). For detailed information on the ethical review process and specific protocols, please refer to the NCHS Research Ethics Review Board Approval page [40]. All participants had provided informed consent. Competing interest: The authors declare no competing interests. EDAT- 2025/09/26 06:31 MHDA- 2025/09/26 06:32 PMCR- 2025/09/25 CRDT- 2025/09/26 00:11 PHST- 2025/06/08 00:00 [received] PHST- 2025/08/16 00:00 [accepted] PHST- 2025/09/26 06:32 [medline] PHST- 2025/09/26 06:31 [pubmed] PHST- 2025/09/26 00:11 [entrez] PHST- 2025/09/25 00:00 [pmc-release] AID - 10.1186/s40001-025-03084-3 [pii] AID - 3084 [pii] AID - 10.1186/s40001-025-03084-3 [doi] PST - epublish SO - Eur J Med Res. 2025 Sep 25;30(1):854. doi: 10.1186/s40001-025-03084-3. PMID- 40997948 OWN - NLM STAT- MEDLINE DCOM- 20251101 LR - 20260518 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 216 DP - 2026 Jan 1 TI - Validating the children's eating behaviour questionnaire in a UK sample: A suitable tool for mothers and fathers. PG - 108322 LID - S0195-6663(25)00475-1 [pii] LID - 10.1016/j.appet.2025.108322 [doi] AB - Children's eating behaviour is a complex construct linked to various health, social, and psychological outcomes. The Children's Eating Behaviour Questionnaire (CEBQ)assesses parents' perceptions of children's eating behaviours across eight subscales: food fussiness, enjoyment of food, food responsiveness, satiety responsiveness, desire to drink, slowness in eating, and emotional under- and overeating. Given that the initial validation of the CEBQ dates back to the early 2000s, this study aimed to (1) evaluate the psychometric properties of the CEBQ in a UK sample using current psychometric recommendations and (2) examine its measurement invariance based on parental sex. A total of 994 caregivers (196 fathers and 798 mothers) of children aged 3-5 years completed the questionnaire. The performance of the scale revealed that 23 items exhibited ceiling or floor effects or failed to meet recommended item-total correlation coefficients. Exploratory factor analysis supported an eight-factor, 34-item structure, which was confirmed via confirmatory factor analysis: X(2) = 2129.845 (df = 499; p < 0.001), TLI = 0.911, CFI = 0.921, RMSEA = 0.083 (90 % CI 0.079-0.087) and SRMR = 0.080. All factors demonstrated adequate internal consistency (omega 3 values over 0.7). Measurement invariance testing confirmed strict invariance by parental sex, indicating the instrument performs equivalently for mothers and fathers. These findings support the use of the revised 34-item CEBQ with its eight original factors for both maternal and paternal respondents. However, future research should consider revising certain CEBQ items included to strengthen its capacity to capture variations in children's eating behaviour, and to provide a more accurate evaluation of the construct. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Lozano-Casanova, Mar AU - Lozano-Casanova M AD - Nursing Department, Faculty of Health Sciences, University of Alicante, Campus San Vicente del Raspeig, Alicante, Spain. FAU - Escribano, Silvia AU - Escribano S AD - Nursing Department, Faculty of Health Sciences, University of Alicante, Campus San Vicente del Raspeig, Alicante, Spain. Electronic address: silvia.escribano@ua.es. FAU - Pickard, Abigail AU - Pickard A AD - School of Psychology and Institute of Health and Neurodevelopment, Aston University, Birmingham, UK; Department of Clinical Psychology, School of Health in Social Science, University of Edinburgh, Edinburgh, UK. FAU - Edwards, Katie L AU - Edwards KL AD - School of Psychology and Institute of Health and Neurodevelopment, Aston University, Birmingham, UK; School of Psychology, University of Birmingham, Birmingham, UK. FAU - Kininmonth, Alice R AU - Kininmonth AR AD - School of Food Science and Nutrition, Faculty of Environment, University of Leeds, UK; Leeds Institute for Data Analytics, University of Leeds, UK. FAU - Richart-Martinez, Miguel AU - Richart-Martinez M AD - Nursing Department, Faculty of Health Sciences, University of Alicante, Campus San Vicente del Raspeig, Alicante, Spain. FAU - Sospedra, Isabel AU - Sospedra I AD - Nursing Department, Faculty of Health Sciences, University of Alicante, Campus San Vicente del Raspeig, Alicante, Spain. FAU - Farrow, Claire AU - Farrow C AD - School of Psychology and Institute of Health and Neurodevelopment, Aston University, Birmingham, UK. FAU - Blissett, Jacqueline AU - Blissett J AD - School of Psychology and Institute of Health and Neurodevelopment, Aston University, Birmingham, UK. LA - eng PT - Journal Article PT - Validation Study DEP - 20250923 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Male MH - Female MH - United Kingdom MH - Child, Preschool MH - *Fathers/psychology MH - Surveys and Questionnaires/standards MH - *Feeding Behavior/psychology MH - *Mothers/psychology MH - Psychometrics MH - Reproducibility of Results MH - Adult MH - *Child Behavior/psychology MH - Factor Analysis, Statistical OTO - NOTNLM OT - Children OT - Eating behaviours OT - Psychometric validation OT - Psychometrics OT - Sex invariance COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/09/26 00:30 MHDA- 2025/11/02 00:33 CRDT- 2025/09/25 19:37 PHST- 2025/04/23 00:00 [received] PHST- 2025/09/22 00:00 [revised] PHST- 2025/09/22 00:00 [accepted] PHST- 2025/11/02 00:33 [medline] PHST- 2025/09/26 00:30 [pubmed] PHST- 2025/09/25 19:37 [entrez] AID - S0195-6663(25)00475-1 [pii] AID - 10.1016/j.appet.2025.108322 [doi] PST - ppublish SO - Appetite. 2026 Jan 1;216:108322. doi: 10.1016/j.appet.2025.108322. Epub 2025 Sep 23. PMID- 40997531 OWN - NLM STAT- MEDLINE DCOM- 20251116 LR - 20251215 IS - 1872-6232 (Electronic) IS - 0378-3782 (Linking) VI - 211 DP - 2025 Dec TI - Associations between cardiorespiratory fitness, activity behavior, physical literacy and parental sports participation in children with a critical congenital heart disease. PG - 106397 LID - S0378-3782(25)00207-5 [pii] LID - 10.1016/j.earlhumdev.2025.106397 [doi] AB - OBJECTIVE: This study investigated associations between cardiorespiratory fitness (CRF), activity behavior (i.e. physical activity and sports participation), physical literacy (motivation, confidence, knowledge and understanding), and parental sports participation in children with critical congenital heart disease (CCHD), and explore differences in children with a single ventricle physiology (SVP) and children with biventricular physiology (BVP). METHODS: Ninety children with CCHD (median age 10.0 [7.0-13.0] years) participated in this prospective observational study. CRF was measured through cardiopulmonary exercise testing (VO(2)peak). Activity behavior, physical literacy, and parental sports participation were assessed using validated questionnaires. RESULTS: CRF was moderately associated with physical activity (r = 0.36, p < .001) and weakly associated with motivation and confidence (r = 0.25, p = .019). No association was found between CRF and sports participation. Children's sports participation was positively associated with maternal (r = 0.23, p = .034) and paternal (r = 0.23, p = .042) sports participation, as well as with motivation and confidence (r = 0.28, p = .009). Children with a SVP (n = 11) had significantly lower CRF than those with BVP (n = 79) (p < .001). No other differences were found between children with a SVP and children with a BVP. CONCLUSION: CRF is positively associated with physical activity, motivation and confidence in children with CCHD. Additionally, parental sports participation is associated with children's sports participation. These findings suggest integrating a physical literacy and family-centered approach in interventions aimed to enhance CRF in children with CCHD. CI - Copyright (c) 2025 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Noordstar, J J AU - Noordstar JJ AD - Child Development & Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address: j.j.noordstar-2@umcutrecht.nl. FAU - Sprong, M C A AU - Sprong MCA AD - Child Development & Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address: M.Sprong-3@umcutrecht.nl. FAU - Lenderink, F C AU - Lenderink FC AD - Child Development & Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address: flenderink@diakhuis.nl. FAU - Slieker, M G AU - Slieker MG AD - Department of Pediatric Cardiology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht, the Netherlands. Electronic address: M.G.Slieker@umcutrecht.nl. FAU - Hulzebos, E H J AU - Hulzebos EHJ AD - Child Development & Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address: H.Hulzebos@umcutrecht.nl. FAU - Takken, T AU - Takken T AD - Child Development & Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address: t.takken@umcutrecht.nl. LA - eng PT - Journal Article PT - Observational Study DEP - 20250918 PL - Ireland TA - Early Hum Dev JT - Early human development JID - 7708381 SB - IM MH - Humans MH - Male MH - Female MH - Child MH - *Heart Defects, Congenital/physiopathology/psychology MH - *Cardiorespiratory Fitness MH - *Sports MH - *Exercise MH - Adolescent MH - Parents MH - Motivation MH - Prospective Studies OTO - NOTNLM OT - Cardiorespiratory fitness OT - Congenital heart disease OT - Motivation OT - Parental influence OT - Physical activity OT - Physical literacy OT - Sports participation COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/09/26 00:30 MHDA- 2025/11/17 00:29 CRDT- 2025/09/25 18:05 PHST- 2025/07/17 00:00 [received] PHST- 2025/09/17 00:00 [revised] PHST- 2025/09/17 00:00 [accepted] PHST- 2025/11/17 00:29 [medline] PHST- 2025/09/26 00:30 [pubmed] PHST- 2025/09/25 18:05 [entrez] AID - S0378-3782(25)00207-5 [pii] AID - 10.1016/j.earlhumdev.2025.106397 [doi] PST - ppublish SO - Early Hum Dev. 2025 Dec;211:106397. doi: 10.1016/j.earlhumdev.2025.106397. Epub 2025 Sep 18. PMID- 40997334 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250925 LR - 20250928 IS - 2371-4379 (Electronic) IS - 2371-4379 (Linking) VI - 10 DP - 2025 Sep 25 TI - Toward a Clinically Actionable, Electronic Health Record-Based Machine Learning Model to Forecast 90-Day Change in Hemoglobin A(1c) in Youth With Type 1 Diabetes: Feasibility and Model Development Study. PG - e69142 LID - 10.2196/69142 [doi] LID - e69142 AB - BACKGROUND: Clinicians currently lack an effective means for identifying youth with type 1 diabetes (T1D) who are at risk for experiencing glycemic deterioration between diabetes clinic visits. As a result, their ability to identify youth who may optimally benefit from targeted interventions designed to address rising glycemic levels is limited. Although electronic health records (EHR)-based risk predictions have been used to forecast health outcomes in T1D, no study has investigated the potential for using EHR data to identify youth with T1D who will experience a clinically significant rise in glycated hemoglobin (HbA1c) >/=0.3% (approximately 3 mmol/mol) between diabetes clinic visits. OBJECTIVE: We aimed to evaluate the feasibility of using routinely collected EHR data to develop a machine learning model to predict 90-day unit-change in HbA1c (in % units) in youth (aged 9-18 y) with T1D. We assessed our model's ability to augment clinical decision-making by identifying a percent change cut point that optimized identification of youth who would experience a clinically significant rise in HbA1c. METHODS: From a cohort of 2757 youth with T1D who received care from a network of pediatric diabetes clinics in the Midwestern United States (January 2012-August 2017), we identified 1743 youth with 9643 HbA1c observation windows (ie, 2 HbA1c measurements separated by 70-110 d, approximating the 90-day time interval between routine diabetes clinic visits). We used up to 5 years of youths' longitudinal EHR data to transform 17,466 features (demographics, laboratory results, vital signs, anthropometric measures, medications, diagnosis codes, procedure codes, and free-text data) for model training. We performed 3-fold cross-validation to train random forest regression models to predict 90-day unit-change in HbA1c(%). RESULTS: Across all 3 folds of our cross-validation model, the average root-mean-square error was 0.88 (95% CI 0.85-0.90). Predicted HbA1c(%) strongly correlated with true HbA1c(%) (r=0.79; 95% CI 0.78-0.80). The top 10 features impacting model predictions included postal code, various metrics related to HbA1c, and the frequency of a diagnosis code indicating difficulty with treatment engagement. At a clinically significant percent rise threshold of >/=0.3% (approximately 3 mmol/mol), our model's positive predictive value was 60.3%, indicating a 1.5-fold enrichment (relative to the observed frequency that youth experienced this outcome [3928/9643, 40.7%]). Model sensitivity and positive predictive value improved when thresholds for clinical significance included smaller changes in HbA1c, whereas specificity and negative predictive value improved when thresholds required larger changes in HbA1c. CONCLUSIONS: Routinely collected EHR data can be used to create an ML model for predicting unit-change in HbA1c between diabetes clinic visits among youth with T1D. Future work will focus on optimizing model performance and validating the model in additional cohorts and in other diabetes clinics. CI - (c) Erin M Tallon, David D Williams, Cintya Schweisberger, Colin Mullaney, Brent Lockee, Diana Ferro, Craig A Vandervelden, Mitchell S Barnes, Angelica Cristello Sarteau, Anna R Kahkoska, Susana R Patton, Sanjeev Mehta, Ryan McDonough, Marcus Lind, Leonard D'Avolio, Mark A Clements. Originally published in JMIR Diabetes (https://diabetes.jmir.org). FAU - Tallon, Erin M AU - Tallon EM AUID- ORCID: 0000-0003-1353-6632 AD - Division of Pediatric Endocrinology and Diabetes, Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO, United States, 1 8166014023. AD - Department of Pediatrics, UMKC School of Medicine, Kansas City, MO, United States. AD - Institute for Data Science and Informatics, University of Missouri-Columbia, Columbia, MO, United States. FAU - Williams, David D AU - Williams DD AUID- ORCID: 0000-0003-0501-3751 AD - Division of Health Services and Outcomes Research, Children's Mercy Kansas City, Kansas City, MO, United States. FAU - Schweisberger, Cintya AU - Schweisberger C AUID- ORCID: 0000-0002-8915-6700 AD - Division of Pediatric Endocrinology and Diabetes, Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO, United States, 1 8166014023. AD - Department of Pediatrics, UMKC School of Medicine, Kansas City, MO, United States. FAU - Mullaney, Colin AU - Mullaney C AUID- ORCID: 0009-0005-4051-7068 AD - Blue Circle Health, Boston, MA, United States. FAU - Lockee, Brent AU - Lockee B AUID- ORCID: 0009-0008-3746-0541 AD - Division of Pediatric Endocrinology and Diabetes, Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO, United States, 1 8166014023. FAU - Ferro, Diana AU - Ferro D AUID- ORCID: 0000-0003-1774-7509 AD - Preventive and Predictive Medicine, IRCCS, Bambino Gesu Children's Hospital, Rome, Italy. FAU - Vandervelden, Craig A AU - Vandervelden CA AUID- ORCID: 0000-0003-1185-7563 AD - Division of Pediatric Endocrinology and Diabetes, Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO, United States, 1 8166014023. FAU - Barnes, Mitchell S AU - Barnes MS AUID- ORCID: 0009-0006-2339-6660 AD - Division of Pediatric Endocrinology and Diabetes, Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO, United States, 1 8166014023. FAU - Sarteau, Angelica Cristello AU - Sarteau AC AUID- ORCID: 0000-0002-7303-4311 AD - Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. FAU - Kahkoska, Anna R AU - Kahkoska AR AUID- ORCID: 0000-0003-2701-101X AD - Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. FAU - Patton, Susana R AU - Patton SR AUID- ORCID: 0000-0002-8902-6965 AD - Center for Healthcare Delivery Science, Nemours Children's Health, Jacksonville, FL, United States. FAU - Mehta, Sanjeev AU - Mehta S AUID- ORCID: 0000-0001-6059-4611 AD - Joslin Diabetes Center, Boston, MA, United States. FAU - McDonough, Ryan AU - McDonough R AUID- ORCID: 0000-0003-1909-3027 AD - Division of Pediatric Endocrinology and Diabetes, Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO, United States, 1 8166014023. AD - Department of Pediatrics, UMKC School of Medicine, Kansas City, MO, United States. AD - Department of Pediatrics, Arkansas Children's Northwest, Springdale, AR, United States. FAU - Lind, Marcus AU - Lind M AUID- ORCID: 0000-0002-3796-9283 AD - Department of Medicine, NU-Hospital Group, Uddevalla, Sweden. AD - Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden. AD - Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden. FAU - D'Avolio, Leonard AU - D'Avolio L AUID- ORCID: 0009-0008-7309-9677 AD - Blue Circle Health, Boston, MA, United States. AD - Harvard Medical School, Boston, MA, United States. AD - Mass General Brigham, Boston, MA, United States. FAU - Clements, Mark A AU - Clements MA AUID- ORCID: 0000-0002-2368-0331 AD - Division of Pediatric Endocrinology and Diabetes, Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO, United States, 1 8166014023. AD - Department of Pediatrics, UMKC School of Medicine, Kansas City, MO, United States. LA - eng GR - K01 AG084971/AG/NIA NIH HHS/United States PT - Journal Article DEP - 20250925 PL - Canada TA - JMIR Diabetes JT - JMIR diabetes JID - 101719410 PMC - PMC12463387 OTO - NOTNLM OT - AI, artificial intelligence OT - EHR, electronic health records OT - HbA1c, hemoglobin A1c OT - T1D, type 1 diabetes OT - adolescent OT - clinical decision support OT - glycemic control OT - machine learning OT - pediatric OT - population health OT - prediction OT - real-world data OT - youth COIS- Conflicts of Interest: CM and LD are employees of Blue Circle Health. RM is a consultant for Sanofi. ML has received research grants from Eli Lilly and Novo Nordisk and has been a consultant or has received honoraria from Astra Zeneca, Boehringer Ingelheim, Eli Lilly, Nordicinfu Care, Novo Nordisk, and Rubin Medical, all outside the submitted work. MAC is a consultant for Glooko, Inc. and receives research support from Dexcom and Abbott Diabetes Care. All other authors are responsible for the reported research and stated that they have no affiliation, financial agreement, or involvement with any company or other organization with a financial interest in the subject matter of the submitted manuscript. EDAT- 2025/09/25 18:30 MHDA- 2025/09/25 18:31 PMCR- 2025/09/25 CRDT- 2025/09/25 17:13 PHST- 2025/01/10 00:00 [received] PHST- 2025/07/01 00:00 [revised] PHST- 2025/07/23 00:00 [accepted] PHST- 2025/09/25 18:31 [medline] PHST- 2025/09/25 18:30 [pubmed] PHST- 2025/09/25 17:13 [entrez] PHST- 2025/09/25 00:00 [pmc-release] AID - v10i1e69142 [pii] AID - 69142 [pii] AID - 10.2196/69142 [doi] PST - epublish SO - JMIR Diabetes. 2025 Sep 25;10:e69142. doi: 10.2196/69142. PMID- 40996216 OWN - NLM STAT- MEDLINE DCOM- 20251001 LR - 20260813 IS - 2998-8756 (Electronic) IS - 2998-8748 (Print) IS - 2998-8748 (Linking) VI - 87 IP - 8 DP - 2025 Oct 1 TI - Neighborhood Opportunity and Biological Aging: Results From the Midlife in the United States. PG - 520-528 LID - 10.1097/PSY.0000000000001419 [doi] AB - OBJECTIVE: To quantify the association between neighborhood opportunity and biological aging as measured by epigenetic clocks. METHODS: This cross-sectional study pooled data from 1205 participants in the Midlife in the United States Biomarker Projects (2004-2016). Neighborhood opportunity was measured continuously based on the Childhood Opportunity Index 3.0, which evaluates census tract conditions across educational, health and environment, and social and economic domains. Biological aging was measured using 3 validated DNA methylation-based indicators: the DunedinPACE, GrimAge2, and PhenoAge. Analyses controlled for the confounding effects of age, sex, race, educational attainment, household income, marital status, perceived neighborhood quality, smoking status, past month alcohol consumption, and body mass index (BMI). RESULTS: Participants living in neighborhoods with low overall opportunity showed a faster pace of aging with DunedinPACE (0.06 SD increase, 95% CI = 0.01, 0.12; p = .029). Similar effects occurred for the health and environment (0.05 SD increase, 95% CI = 0.01, 0.10; p = .023) and social and economic (0.07 SD increase, 95% CI = 0.01, 0.12; p = .026) domains of the overall opportunity score. GrimAge2 and PhenoAge showed similar associations, but those were attenuated after adjusting for sociodemographic characteristics and health behaviors. CONCLUSIONS: Low neighborhood opportunity, particularly in health and environment and social and economic domains, is associated with accelerated biological aging. Health behaviors may contribute to these effects, and additional mechanisms need to be examined in future research. CI - Copyright (c) 2025 Society for Biopsychosocial Science and Medicine. FAU - Cuevas, Adolfo G AU - Cuevas AG AUID- ORCID: 0000-0001-9875-3825 FAU - Bather, Jemar R AU - Bather JR FAU - Kranz, Emiko AU - Kranz E FAU - Zhang, Xiaoyan AU - Zhang X FAU - Cole, Steven W AU - Cole SW LA - eng GR - P30 AG017265/AG/NIA NIH HHS/United States GR - U19 AG051426/AG/NIA NIH HHS/United States GR - R01 DK137805/DK/NIDDK NIH HHS/United States GR - U01 AG077928/AG/NIA NIH HHS/United States GR - R01 DK137246/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20250714 PL - United States TA - Biopsychosoc Sci Med JT - Biopsychosocial science and medicine JID - 9918976361906676 SB - IM MH - Humans MH - Female MH - Male MH - Cross-Sectional Studies MH - Middle Aged MH - United States MH - *Aging/physiology/genetics MH - *Neighborhood Characteristics/statistics & numerical data MH - *Residence Characteristics/statistics & numerical data MH - Adult MH - Socioeconomic Factors MH - DNA Methylation MH - Aged PMC - PMC12949979 MID - NIHMS2131468 OTO - NOTNLM OT - DNA methylation OT - accelerated aging OT - biological embedding OT - place-based health OT - residential environment COIS- Conflicts of Interest: The authors report no conflicts of interest. EDAT- 2025/09/25 12:43 MHDA- 2025/10/01 18:29 PMCR- 2026/03/01 CRDT- 2025/09/25 09:05 PHST- 2025/03/18 00:00 [received] PHST- 2025/06/16 00:00 [accepted] PHST- 2025/10/01 18:29 [medline] PHST- 2025/09/25 12:43 [pubmed] PHST- 2025/09/25 09:05 [entrez] PHST- 2026/03/01 00:00 [pmc-release] AID - 02276378-202510000-00003 [pii] AID - 10.1097/PSY.0000000000001419 [doi] PST - ppublish SO - Biopsychosoc Sci Med. 2025 Oct 1;87(8):520-528. doi: 10.1097/PSY.0000000000001419. Epub 2025 Jul 14. PMID- 40996209 OWN - NLM STAT- MEDLINE DCOM- 20250925 LR - 20250925 IS - 3105-9686 (Electronic) IS - 1011-601X (Linking) VI - 38 IP - 5 DP - 2025 Sep-Oct TI - Prevalence and clinical significance of glutamic acid decarboxylase antibodies among young diabetic patients in Faisalabad, Punjab. PG - 1932-1939 LID - 10.36721/PJPS.2025.38.5.REG.14746.1 [doi] AB - Glutamic acid decarboxylase (GAD) antibodies are markers of pancreatic beta-cell autoimmunity and play a critical role in understanding the autoimmune component of diabetes mellitus. Despite its importance for distinguishing autoimmune diabetes, limited data exists on GAD antibody among young patients. This study determined the prevalence and clinical significance of GAD antibodies among young diabetic patients in Faisalabad, Punjab, Pakistan. This cross-sectional study recruited diabetic patients aged /=15 y from the NutriNet-Sante cohort was used. Dietary intakes (reported as grams per day) were assessed using >/=2 24-h dietary records, which were then classified into 42 food groups. CVD events were assessed using health questionnaires and subsequently validated based on medical records. GGMs were employed with the Louvain algorithm to derive DP networks. GGMs are network models that depict relationships among many variables (food groups) based on conditional correlation matrices. The Louvain algorithm extracts nonoverlapping communities from large networks. The relationship between DP networks and CVD incidence was evaluated using proportional hazard Cox models, adjusted for confounding variables. RESULTS: Analyses revealed 5 distinct DP networks reflecting consumption of 1) appetizer foods, 2) breakfast foods, 3) plant-based foods, 4) ultraprocessed sweets and snacks, and 5) healthy foods. Among these, only the DP network of ultraprocessed sweets and snacks was associated with greater CVD risk when adjusted for energy and potential confounders including overall diet quality (hazard ratio of quintile 5 compared with quintile 1: 1.32; 95% confidence interval: 1.11, 1.57; P-trend = 0.0002). CONCLUSIONS: The results suggest that a DP network reflecting the consumption of ultraprocessed sweets and snacks is associated with incident CVD in a sample of the French population, independent of diet quality. The innovative approach to derive empirical DP networks may assist in the identification of food groups that are likely to be consumed together in a population, thereby helping to identify dietary habits to target for the prevention of CVD. This trial was registered at clinicaltrials.gov as NCT03335644. CI - Copyright (c) 2025 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Cote, Melina AU - Cote M AD - Centre Nutrition, Sante et Societe (NUTRISS), Institut sur la Nutrition et les Aliments Fonctionnels (INAF), Universite Laval, Quebec, Quebec, Canada; Ecole de Nutrition, Universite Laval, Quebec, Quebec, Canada. FAU - Hutchinson, Joy M AU - Hutchinson JM AD - Centre Nutrition, Sante et Societe (NUTRISS), Institut sur la Nutrition et les Aliments Fonctionnels (INAF), Universite Laval, Quebec, Quebec, Canada. FAU - Touvier, Mathilde AU - Touvier M AD - Universite Sorbonne Paris Nord and Universite Paris Cite, INSERM, INRAE, CNAM, Centre of Research in Epidemiology and StatisticS (CRESS), Nutritional Epidemiology Research Team (EREN), Bobigny, France. FAU - Srour, Bernard AU - Srour B AD - Universite Sorbonne Paris Nord and Universite Paris Cite, INSERM, INRAE, CNAM, Centre of Research in Epidemiology and StatisticS (CRESS), Nutritional Epidemiology Research Team (EREN), Bobigny, France. FAU - Bourhis, Laurent AU - Bourhis L AD - Universite Sorbonne Paris Nord and Universite Paris Cite, INSERM, INRAE, CNAM, Centre of Research in Epidemiology and StatisticS (CRESS), Nutritional Epidemiology Research Team (EREN), Bobigny, France. FAU - Lamarche, Benoit AU - Lamarche B AD - Centre Nutrition, Sante et Societe (NUTRISS), Institut sur la Nutrition et les Aliments Fonctionnels (INAF), Universite Laval, Quebec, Quebec, Canada; Ecole de Nutrition, Universite Laval, Quebec, Quebec, Canada. Electronic address: benoit.lamarche@fsaa.ulaval.ca. FAU - Fezeu, Leopold K AU - Fezeu LK AD - Universite Sorbonne Paris Nord and Universite Paris Cite, INSERM, INRAE, CNAM, Centre of Research in Epidemiology and StatisticS (CRESS), Nutritional Epidemiology Research Team (EREN), Bobigny, France. Electronic address: l.fezeu@eren.smbh.univ-paris13.fr. LA - eng SI - ClinicalTrials.gov/NCT03335644 PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20250922 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - *Algorithms MH - *Cardiovascular Diseases/epidemiology MH - Cohort Studies MH - *Diet MH - *Feeding Behavior MH - France/epidemiology MH - *Machine Learning MH - Risk Factors PMC - PMC12799445 OTO - NOTNLM OT - Gaussian graphical model OT - Louvain algorithm OT - NutriNet-Sante OT - cardiovascular incidence OT - dietary patterns COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2025/09/25 00:28 MHDA- 2025/11/12 23:30 PMCR- 2025/09/23 CRDT- 2025/09/24 19:40 PHST- 2025/06/02 00:00 [received] PHST- 2025/09/10 00:00 [revised] PHST- 2025/09/17 00:00 [accepted] PHST- 2025/11/12 23:30 [medline] PHST- 2025/09/25 00:28 [pubmed] PHST- 2025/09/24 19:40 [entrez] PHST- 2025/09/23 00:00 [pmc-release] AID - S0022-3166(25)00558-9 [pii] AID - 10.1016/j.tjnut.2025.09.014 [doi] PST - ppublish SO - J Nutr. 2025 Nov;155(11):4033-4042. doi: 10.1016/j.tjnut.2025.09.014. Epub 2025 Sep 22. PMID- 40991672 OWN - NLM STAT- MEDLINE DCOM- 20251007 LR - 20260904 IS - 1935-2735 (Electronic) IS - 1935-2727 (Print) IS - 1935-2727 (Linking) VI - 19 IP - 9 DP - 2025 Sep TI - A multifaceted molecular approach to surveillance of leishmaniasis: Identification of sand fly species, Leishmania parasites, and blood meal sources using high-resolution melting analysis. PG - e0013412 LID - 10.1371/journal.pntd.0013412 [doi] LID - e0013412 AB - Leishmaniasis is a significant public health concern in large parts of the world including Israel, with limited diagnostic tools available for effective surveillance and control. Traditional methods for sand fly species identification, Leishmania detection, and blood meal analysis are time-consuming and prone to errors. To address these challenges, this study aimed to develop PCR-high resolution melt (HRM) assays to accurately determine sand fly species, Leishmania infection and blood meal sources in sand flies. Field-collected sand flies from all regions of Israel were used for the validation of three PCR-HRM assays. These included 254 sand fly males and females identified morphologically for species verification; 1,120 unfed females for Leishmania detection, and 538 engorged females for blood meal identification. PCR products were subjected to HRM curve analysis, and results were compared to nucleotide sequencing and sand fly morphology. Eleven sand fly species, 25 different host species blood meals and four Leishmania species were discerned and each presented a specific HRM pattern. Of the 1,658 analyzed females, 16 (1%) were positive for Leishmania, and the species identified were: Leishmania major, L. tropica, L. infantum and L. donovani. Blood meal source was identified in 520 (96.7%) engorged females. Blood from four animal species (domestic cat, rock hyrax, European hare, cow) accounted for 53% of the sand fly blood meals and the remaining 47% came from 21 other animal species. The sand fly species distribution showed that L. major and L. donovani vectors were mostly prevalent in arid southern Israel while L. tropica and L. infantum vectors were abundant in central and northern Israel. These results present the current knowledge of the different Leishmania species life cycles, vectors, and host species present in Israel and substantiate the utility of the assays developed herein which combine the advantages of PCR and the discriminatory power of HRM. CI - Copyright: (c) 2025 Studentsky et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Studentsky, Liora AU - Studentsky L AUID- ORCID: 0000-0002-1469-4301 AD - Ministry of Health, Public Health Laboratories, Jerusalem, Israel. AD - The Hebrew University of Jerusalem, Rehovot, Israel. FAU - Akad, Fouad AU - Akad F AD - Ministry of Health, National Laboratory for Public Health, Tel Aviv, Israel. FAU - Diaz, Debora AU - Diaz D AD - Ministry of Health, Public Health Laboratories, Jerusalem, Israel. FAU - Ben Avi, Irina AU - Ben Avi I AD - Ministry of Health, Public Health Laboratories, Jerusalem, Israel. FAU - Elbaz, Shirly Lea AU - Elbaz SL AD - Ministry of Health, Public Health Laboratories, Jerusalem, Israel. FAU - Grossman, Tamar AU - Grossman T AD - Ministry of Health, Public Health Laboratories, Jerusalem, Israel. FAU - Davidovich-Cohen, Maya AU - Davidovich-Cohen M AD - Ministry of Health, Public Health Laboratories, Jerusalem, Israel. FAU - Kirstein, Oscar David AU - Kirstein OD AD - Ministry of Health, Public Health Laboratories, Jerusalem, Israel. FAU - Orshan, Laor AU - Orshan L AD - Ministry of Health, Public Health Laboratories, Jerusalem, Israel. FAU - Baneth, Gad AU - Baneth G AD - The Hebrew University of Jerusalem, Rehovot, Israel. LA - eng PT - Journal Article DEP - 20250924 PL - United States TA - PLoS Negl Trop Dis JT - PLoS neglected tropical diseases JID - 101291488 SB - IM MH - Animals MH - *Leishmania/isolation & purification/genetics/classification MH - *Psychodidae/parasitology/classification/genetics MH - Female MH - Israel/epidemiology MH - Male MH - *Leishmaniasis/epidemiology/parasitology/transmission MH - *Polymerase Chain Reaction/methods MH - *Insect Vectors/parasitology/classification MH - Blood/parasitology MH - Humans MH - Feeding Behavior PMC - PMC12503242 COIS- The authors have declared that no competing interests exist. EDAT- 2025/09/24 18:33 MHDA- 2025/10/07 18:29 PMCR- 2025/09/24 CRDT- 2025/09/24 13:54 PHST- 2025/02/06 00:00 [received] PHST- 2025/07/30 00:00 [accepted] PHST- 2025/10/07 00:00 [revised] PHST- 2025/10/07 18:29 [medline] PHST- 2025/09/24 18:33 [pubmed] PHST- 2025/09/24 13:54 [entrez] PHST- 2025/09/24 00:00 [pmc-release] AID - PNTD-D-25-00186 [pii] AID - 10.1371/journal.pntd.0013412 [doi] PST - epublish SO - PLoS Negl Trop Dis. 2025 Sep 24;19(9):e0013412. doi: 10.1371/journal.pntd.0013412. eCollection 2025 Sep. PMID- 40989703 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250924 LR - 20250926 IS - 2234-943X (Print) IS - 2234-943X (Electronic) IS - 2234-943X (Linking) VI - 15 DP - 2025 TI - Telemedicine-based adapted physical activity programs for pediatric oncology patients in active oncological care: a feasibility study. PG - 1634626 LID - 10.3389/fonc.2025.1634626 [doi] LID - 1634626 AB - BACKGROUND: Survival rates for pediatric hematological malignancies have significantly improved over the last 50 years. However, children undergoing cancer treatment face long- term health challenges, including musculoskeletal impairments and reduced physical activity levels, which contribute to poorer quality of life (QoL) and elevated cardiovascular risks. Barriers to accessing traditional physical activity and rehabilitation programs necessitate innovative approaches like telemedicine-based interventions. OBJECTIVE: The primary objective was to evaluate the feasibility and adherence of a telemedicine-integrated adapted physical activity (APA) program in pediatric oncology patients. Effectiveness, in terms of functional and psychosocial outcomes, was considered as an exploratory secondary endpoint. Although some statistically significant findings were observed, these results should be interpreted as supportive evidence and not as definitive proof of effectiveness. METHODS: The study included children and adolescents (5-18 years) with onco-hematological conditions. Participants underwent baseline (Pre-APA) and six-month (post-APA) assessments using different functional tests and validated QoL evaluation tools (PedsQL(TM)). The intervention comprised personalized exercise regimens targeting strength, aerobic capacity, flexibility, and balance. Supervised training sessions were conducted both in-person and remotely via telemedicine solutions. Secondary outcomes included quadriceps muscle and hand- grip strength, balance, fatigue, and health-related QoL. Statistical analyses utilized mixed regression models to evaluate pre-post intervention changes and the impact of remote training. RESULTS: Eighteen subjects (8 female, median age 12 years) were included. The APA program demonstrated high adherence (median 77.08%). Preliminary improvements were observed in QoL (PedsQL(TM) child, p=0.007), fatigue (p=0.035), and functional performance (chair stand test, p=0.033). Regression analysis indicated a positive correlation between remote training frequency and QoL improvement (p=0.027, R(2)=0.235). Although strength measures showed no significant improvement, remote training influenced flexibility outcomes. Parental perceptions of fatigue and QoL also improved (p=0.049). CONCLUSION: Telemedicine-based APA programs are a feasible and effective approach for enhancing QoL and functional capacity in pediatric oncology patients. These preliminary findings support the integration of digital health solutions in long-term survivorship care, though larger studies are needed to confirm these results. CI - Copyright (c) 2025 Peli, Inselvini, Cogliati, Finazzi, Gorio, Angeloni, Pollet, Schumacher, Porta, Bertoni and Gobbo. FAU - Peli, Linda AU - Peli L AD - Lega Italiana Lotta Tumori (LILT), Brescia, Italy. FAU - Inselvini, Elisa AU - Inselvini E AD - Lega Italiana Lotta Tumori (LILT), Brescia, Italy. FAU - Cogliati, Marta AU - Cogliati M AD - Dipartimento di Scienze Cliniche e Sperimentali, Universita degli Studi di Brescia, Brescia, Italy. FAU - Finazzi, Eleonora AU - Finazzi E AD - Lega Italiana Lotta Tumori (LILT), Brescia, Italy. FAU - Gorio, Chiara AU - Gorio C AD - Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Brescia, Italy. FAU - Angeloni, Alessia AU - Angeloni A AD - Lega Italiana Lotta Tumori (LILT), Brescia, Italy. FAU - Pollet, Joel AU - Pollet J AD - Dipartimento di Scienze Cliniche e Sperimentali, Universita degli Studi di Brescia, Brescia, Italy. AD - IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy. FAU - Schumacher, Richard F AU - Schumacher RF AD - Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Brescia, Italy. FAU - Porta, Fulvio AU - Porta F AD - Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Brescia, Italy. FAU - Bertoni, Filippo AU - Bertoni F AD - Lega Italiana Lotta Tumori (LILT), Brescia, Italy. FAU - Gobbo, Massimiliano AU - Gobbo M AD - Dipartimento di Scienze Cliniche e Sperimentali, Universita degli Studi di Brescia, Brescia, Italy. AD - IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy. LA - eng PT - Journal Article DEP - 20250908 PL - Switzerland TA - Front Oncol JT - Frontiers in oncology JID - 101568867 PMC - PMC12450653 OTO - NOTNLM OT - cancer OT - exercise OT - functional status OT - hematology OT - quality of life OT - rehabilitation OT - survivorship OT - telemedicine COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/09/24 06:28 MHDA- 2025/09/24 06:29 PMCR- 2025/09/08 CRDT- 2025/09/24 05:26 PHST- 2025/05/24 00:00 [received] PHST- 2025/08/14 00:00 [accepted] PHST- 2025/09/24 06:29 [medline] PHST- 2025/09/24 06:28 [pubmed] PHST- 2025/09/24 05:26 [entrez] PHST- 2025/09/08 00:00 [pmc-release] AID - 10.3389/fonc.2025.1634626 [doi] PST - epublish SO - Front Oncol. 2025 Sep 8;15:1634626. doi: 10.3389/fonc.2025.1634626. eCollection 2025. PMID- 40988152 OWN - NLM STAT- MEDLINE DCOM- 20250924 LR - 20250927 IS - 1365-277X (Electronic) IS - 0952-3871 (Print) IS - 0952-3871 (Linking) VI - 38 IP - 5 DP - 2025 Oct TI - Psychometric Properties of Eating Behaviour Instruments for Older Adults: A Systematic Review. PG - e70127 LID - 10.1111/jhn.70127 [doi] LID - e70127 AB - INTRODUCTION: Although eating behaviour in children, adolescents and adults has been linked to changes in body mass, eating disorders and non-communicable diseases, there is still uncertainty about how this behaviour has been measured in populations aged 60 and over, who are often exposed to age-related physiological and cognitive changes, increased malnutrition risk and underrepresented in psychometric research. AIM: To analyse how eating behaviour has been investigated in people aged 60 and over. METHODS: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN), three independent researchers selected articles from four databases from 2000 to the present. INCLUSION CRITERIA: (1) Studies on adaptation, development, or evaluation of psychometric properties of eating behaviour instruments; (2) Studies with participants aged >/= 60 years, or with a significant proportion/stratified results for this group; (3) Publications in English, Spanish, or Portuguese; and (4) Articles published from 2000 to 2024. EXCLUSION CRITERIA: (1) Studies on food consumption; (2) Instruments for diagnosing eating disorders; and (3) Non-original articles. RESULTS: Eight instruments were identified for assessing eating behaviour in older adults, with the majority developed in Europe. Methodological shortcomings were present across all instruments, particularly in the areas of development, content validity, internal validity and consistency. CONCLUSIONS: All instruments exhibit questionable methodological robustness, highlighting the need for more rigorous and culturally sensitive approaches to the development and adaptation of tools for this population. CI - (c) 2025 The Author(s). Journal of Human Nutrition and Dietetics published by John Wiley & Sons Ltd on behalf of British Dietetic Association. FAU - de Padua Constancio, Giulia AU - de Padua Constancio G AUID- ORCID: 0000-0003-3894-2709 AD - Federal University of Bahia, Salvador, Bahia, Brazil. FAU - de Souza Silva, Gisele Teixeira AU - de Souza Silva GT AUID- ORCID: 0009-0003-1956-632X AD - Federal University of Bahia, Salvador, Bahia, Brazil. FAU - Bahia, Maria Fernanda Ferrari AU - Bahia MFF AUID- ORCID: 0009-0005-3716-0133 AD - Federal University of Bahia, Salvador, Bahia, Brazil. FAU - de Castro, Marcela Rodrigues AU - de Castro MR AUID- ORCID: 0000-0003-3771-1386 AD - Federal University of Bahia, Salvador, Bahia, Brazil. LA - eng GR - This study received institutional support from the Federal University of Bahia, through the agreement with CAPES (Coordination for the Improvement of Higher Education Personnel) for the waiver of article processing charges (APC)./ PT - Journal Article PT - Systematic Review PL - England TA - J Hum Nutr Diet JT - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JID - 8904840 SB - IM MH - Aged MH - Aged, 80 and over MH - Female MH - Humans MH - Male MH - Middle Aged MH - Feeding and Eating Disorders/diagnosis MH - *Feeding Behavior/psychology MH - *Psychometrics MH - Reproducibility of Results MH - Surveys and Questionnaires PMC - PMC12457733 OTO - NOTNLM OT - eating behaviour OT - older adults OT - psychometric COIS- The authors declare no conflicts of interest. EDAT- 2025/09/24 06:29 MHDA- 2025/09/24 06:30 PMCR- 2025/09/24 CRDT- 2025/09/24 00:55 PHST- 2025/09/02 00:00 [revised] PHST- 2025/05/29 00:00 [received] PHST- 2025/09/05 00:00 [accepted] PHST- 2025/09/24 06:30 [medline] PHST- 2025/09/24 06:29 [pubmed] PHST- 2025/09/24 00:55 [entrez] PHST- 2025/09/24 00:00 [pmc-release] AID - JHN70127 [pii] AID - 10.1111/jhn.70127 [doi] PST - ppublish SO - J Hum Nutr Diet. 2025 Oct;38(5):e70127. doi: 10.1111/jhn.70127. PMID- 40987612 OWN - NLM STAT- MEDLINE DCOM- 20260206 LR - 20260813 IS - 2234-3814 (Electronic) IS - 2234-3806 (Print) IS - 2234-3806 (Linking) VI - 46 IP - 2 DP - 2026 Mar 1 TI - Development and Validation of a High-performance Liquid Chromatography-Tandem Mass Spectrometry Method for Detecting Adrenocortical Hormones and Establishment of Age-stratified Reference Intervals in Reproductive-aged Women from Guangxi, China. PG - 146-154 LID - 10.3343/alm.2025.0090 [doi] AB - BACKGROUND: Adrenocortical hormones, particularly 11-oxygenated androgens, are pivotal in female reproductive health and fertility. Standardized detection kits and population-specific reference intervals are lacking in China, hindering related clinical applications. METHODS: A HPLC-tandem mass spectrometry (HPLC-MS/MS) pipeline was developed, rigorously validated, and applied to simultaneously quantify corticosterone, cortisone, cortisol, 18-OH cortisol, androstenedione (A4), 11beta-hydroxyandrostenedione (11-OH A4), dehydroepiandrosterone, and dehydroepiandrosterone sulfate in serum samples from 455 reproductive-aged women (18-45 yrs) in Guangxi, China. Age-dependent concentration trends were analyzed, and reference intervals stratified by age (2.5th to 97.5th percentiles) were established. Correlations with body-composition metrics, ethnicity, and the menstrual cycle were investigated. RESULTS: The HPLC-MS/MS method demonstrated high precision (intra- and inter-assay CVs <15%), accuracy, and sensitivity. All eight hormones exhibited significant age-related declines (P <0.001 for seven hormones; P =0.001 for 11-OH A4). Notably, 11-OH A4 levels were significantly lower in the 35-45-yr (3.05 nmol/L) and 25-34-yr (3.09 nmol/L) age groups than in the 18-24-yr (3.57 nmol/L) age group, whereas no significant difference was observed between the 35-45-yr and 25-34-yr age groups. Weak negative correlations were observed between the body mass index and corticosterone and cortisone levels, whereas ethnicity and the menstrual cycle showed no significant associations with hormone levels. CONCLUSIONS: We developed an HPLC-MS/MS-based method for simultaneously quantifying eight adrenocortical hormones, including 11-OH A4, and defined age-specific reference intervals for reproductive-aged Chinese women. These findings advance the clinical utility of adrenocortical hormones in diagnosing and managing reproductive disorders. FAU - Liu, Yixuan AU - Liu Y AUID- ORCID: 0009-0008-0832-5009 AD - Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Guangxi Medical University, Nanning, China. AD - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medic. FAU - Jin, Tingwei AU - Jin T AUID- ORCID: 0009-0004-8051-0306 AD - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medic. FAU - Wei, Yushuang AU - Wei Y AUID- ORCID: 0009-0009-4099-0989 AD - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medic. FAU - Qin, Xuelian AU - Qin X AUID- ORCID: 0009-0009-4657-8952 AD - Guangxi Precision Medicine Industrial Technology Institute, Nanning, China. FAU - Deng, Siyu AU - Deng S AUID- ORCID: 0009-0002-6664-7299 AD - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medic. FAU - Zheng, Jie AU - Zheng J AUID- ORCID: 0000-0002-8250-7061 AD - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medic. FAU - Yan, Boteng AU - Yan B AUID- ORCID: 0009-0005-1247-1541 AD - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medic. FAU - Nong, Yuanyuan AU - Nong Y AUID- ORCID: 0009-0006-9487-7058 AD - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medic. FAU - Ye, Yu AU - Ye Y AUID- ORCID: 0000-0002-7025-436X AD - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medic. FAU - Huang, Shengzhu AU - Huang S AUID- ORCID: 0000-0002-0956-5097 AD - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medic. FAU - Long, Yu AU - Long Y AUID- ORCID: 0000-0002-5518-5343 AD - Department of Obstetrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. FAU - Li, Jianmin AU - Li J AUID- ORCID: 0009-0007-7051-5594 AD - Department of Hospital Office, The Second Nanning People's Hospital, Nanning, China. FAU - Wang, Ganqin AU - Wang G AUID- ORCID: 0009-0009-8534-6476 AD - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medic. AD - Department of Hospital Office, The Second Nanning People's Hospital, Nanning, China. FAU - Huang, Pei AU - Huang P AUID- ORCID: 0009-0002-9233-8801 AD - Eugenics and Genetics Department, Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, China. FAU - Jiang, Jinghang AU - Jiang J AUID- ORCID: 0000-0001-7019-5307 AD - The Reproductive Medicine Center, Jingmen People's Hospital, Jingmen China. FAU - Wu, Fan AU - Wu F AUID- ORCID: 0009-0007-0918-5223 AD - Guangxi Precision Medicine Industrial Technology Institute, Nanning, China. FAU - Mo, Zengnan AU - Mo Z AUID- ORCID: 0000-0002-3047-3138 AD - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medic. AD - Guangxi Precision Medicine Industrial Technology Institute, Nanning, China. FAU - Jiang, Yonghua AU - Jiang Y AUID- ORCID: 0000-0003-2927-4921 AD - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medic. AD - Department of Gynecology, the Second Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Nanning, China. AD - Life Sciences Institute, Guangxi Medical University, Nanning, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20250924 PL - Korea (South) TA - Ann Lab Med JT - Annals of laboratory medicine JID - 101571172 RN - 0 (Adrenal Cortex Hormones) RN - WI4X0X7BPJ (Hydrocortisone) RN - 57B09Q7FJR (Dehydroepiandrosterone Sulfate) RN - 409J2J96VR (Androstenedione) SB - IM MH - Humans MH - Female MH - *Tandem Mass Spectrometry/methods MH - Adult MH - Chromatography, High Pressure Liquid/methods MH - Adolescent MH - Middle Aged MH - China MH - Young Adult MH - Reference Values MH - *Adrenal Cortex Hormones/blood/standards MH - Age Factors MH - Hydrocortisone/blood MH - Dehydroepiandrosterone Sulfate/blood MH - Androstenedione/blood PMC - PMC12915376 OTO - NOTNLM OT - 11-Oxygenated androgens OT - Adrenocortical hormones OT - Age-stratified reference intervals OT - High-performance liquid chromatography-tandem mass spectrometry COIS- CONFLICTS OF INTEREST None declared. EDAT- 2025/09/24 00:39 MHDA- 2026/02/06 06:41 PMCR- 2025/09/24 CRDT- 2025/09/23 21:43 PHST- 2025/02/15 00:00 [received] PHST- 2025/05/11 00:00 [revised] PHST- 2025/08/13 00:00 [accepted] PHST- 2026/02/06 06:41 [medline] PHST- 2025/09/24 00:39 [pubmed] PHST- 2025/09/23 21:43 [entrez] PHST- 2025/09/24 00:00 [pmc-release] AID - alm.2025.0090 [pii] AID - alm-46-2-146 [pii] AID - 10.3343/alm.2025.0090 [doi] PST - ppublish SO - Ann Lab Med. 2026 Mar 1;46(2):146-154. doi: 10.3343/alm.2025.0090. Epub 2025 Sep 24. PMID- 40986304 OWN - NLM STAT- MEDLINE DCOM- 20250923 LR - 20260719 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 8 IP - 9 DP - 2025 Sep 2 TI - Age, Sex, BMI, Meal Timing, and Glycemic Response to Meal Glycemic Load. PG - e2533193 LID - 10.1001/jamanetworkopen.2025.33193 [doi] LID - e2533193 AB - IMPORTANCE: Postprandial glycemic responses contribute to comorbidities and mortality risk, but the association between food and postprandial glucose responses in general population settings remains uncertain. OBJECTIVE: To investigate the association of dietary glycemic load (GL), meal timing, age, sex, body mass index (BMI), and glycated hemoglobin (HbA1c) concentration with postprandial glycemic response to mixed meals. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study was conducted from August 21, 2012, to March 26, 2015, at a primary health care center in A Estrada, northwestern Spain. A population-based sample of adults aged 18 to 85 years without diabetes who were randomly selected from National Health System records agreed to participate. Data analysis was performed between April 20, 2023, and March 26, 2024. EXPOSURE: The main exposure was dietary GL. Additional exposures included age, sex, BMI, meal timing, and HbA1c concentration. MAIN OUTCOME AND MEASURES: Postprandial glucose response over 3 hours after breakfast, lunch, and dinner was assessed using continuous glucose monitoring (CGM) for 7 days, with dietary assessments. Multilevel regression models evaluated the association between GL and glucose dynamics, accounting for age, sex, BMI, meal timing, and HbA1c concentration. RESULTS: Of the 622 participants fitted with the CGM device, 514 (median age, 46 years [IQR, 36-58 years]; 64% females) met eligibility criteria and provided analyzable data. More than 1.3 million glucose measurements were analyzed across 2451 days. Dietary GL was associated with higher postprandial blood glucose levels, with maximum rises of up to 1.3 (95% CI, 0.8-1.8) mg/dL per 10 units of GL. Glucose responses were greater and more prolonged after lunches and dinners than after breakfasts, with peak values observed at 70 minutes after lunches and dinners and 50 minutes after breakfasts. Each 10-year increase in age was associated with an increase in postprandial glucose levels of 1.9 (95% CI, 0.6-3.3) mg/dL to 3.5 (95% CI, 2.2-4.8) mg/dL, while BMI was associated with glucose response after breakfast, with increases of up to 0.7 (95% CI, 0.4-1.1) mg/dL per BMI unit increase. Men had lower glucose levels than women during the late postprandial period after lunch and dinner, with differences of up to 4.6 (95% CI, 1.6-7.6) mg/dL. HbA1c concentrations and meal timing were also associated with postprandial glucose levels (eg, glucose levels increased up to 12.0 [95% CI, 6.5-17.5] mg/dL per 1% increase in HbA1c). CONCLUSIONS AND RELEVANCE: In this cross-sectional study of adults without diabetes, higher-GL meals were associated with sustained postprandial glucose elevations, especially after lunch and dinner. Age, sex, BMI, meal timing, and HbA1c concentration were also associated with glucose responses. These findings support the validity of dietary GL as an explanatory factor for glycemic response to mixed meals under typical everyday conditions when meal timing, age, and BMI are considered. FAU - Calvo-Malvar, Mar AU - Calvo-Malvar M AD - Department of Laboratory Medicine, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain. AD - Research Methodology Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain. FAU - Lado-Baleato, Oscar AU - Lado-Baleato O AD - Research Methodology Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain. AD - ISCIII Instituto de Salud Carlos III Support Platforms for Clinical Research, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain. AD - Unit of Biostatistics, Department of Statistics, Mathematical Analysis, and Optimization, University of Santiago de Compostela, Santiago de Compostela, Spain. FAU - Rios, Ana Cao AU - Rios AC AD - Research Methodology Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain. FAU - Fernandez, Cristina Porca AU - Fernandez CP AD - Department of Endocrinology and Nutrition, University Hospital Complex of Ferrol, Ferrol, Spain. AD - Epigenomics in Endocrinology and Nutrition Group, Santiago Health Research Institute (IDIS), Santiago de Compostela, Spain. FAU - Benitez-Calvo, Alfonso AU - Benitez-Calvo A AD - Department of Radiology, Hospital Lucus Augusti, Lugo, Spain. FAU - Fernandez-Merino, Carmen AU - Fernandez-Merino C AD - Research Methodology Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain. AD - A Estrada Primary Care Center, A Estrada, Pontevedra, Spain. AD - Department of Psychiatry, Radiology, Public Health, Nursing, and Medicine, University of Santiago, Santiago de Compostela, Spain. FAU - Sanchez-Castro, Juan AU - Sanchez-Castro J AD - Research Methodology Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain. AD - Department of Psychiatry, Radiology, Public Health, Nursing, and Medicine, University of Santiago, Santiago de Compostela, Spain. FAU - Wagner, Robert AU - Wagner R AD - Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Dusseldorf, Heinrich Heine University Dusseldorf, Dusseldorf, Germany. AD - Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Dusseldorf, Dusseldorf, Germany. AD - German Center for Diabetes Research (DZD), Neuherberg, Germany. FAU - Matabuena, Marcos AU - Matabuena M AD - Department of Biostatistics, Harvard University, Boston, Massachusetts. FAU - Gude, Francisco AU - Gude F AD - Research Methodology Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain. AD - Department of Psychiatry, Radiology, Public Health, Nursing, and Medicine, University of Santiago, Santiago de Compostela, Spain. AD - Primary Care Concepcion Arenal, Santiago de Compostela, Spain. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250902 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 RN - 0 (Blood Glucose) RN - 0 (Glycated Hemoglobin) SB - IM MH - Humans MH - Male MH - Female MH - Middle Aged MH - Adult MH - Cross-Sectional Studies MH - Body Mass Index MH - Aged MH - *Blood Glucose/analysis/metabolism MH - *Postprandial Period/physiology MH - *Meals/physiology MH - Glycated Hemoglobin/analysis MH - *Glycemic Load/physiology MH - Young Adult MH - Age Factors MH - Sex Factors MH - Adolescent MH - Aged, 80 and over MH - Spain PMC - PMC12457981 COIS- Conflict of Interest Disclosures: None reported. EDAT- 2025/09/23 12:46 MHDA- 2025/09/23 12:47 PMCR- 2025/09/23 CRDT- 2025/09/23 11:33 PHST- 2025/09/23 12:47 [medline] PHST- 2025/09/23 12:46 [pubmed] PHST- 2025/09/23 11:33 [entrez] PHST- 2025/09/23 00:00 [pmc-release] AID - 2839231 [pii] AID - zoi250935 [pii] AID - 10.1001/jamanetworkopen.2025.33193 [doi] PST - epublish SO - JAMA Netw Open. 2025 Sep 2;8(9):e2533193. doi: 10.1001/jamanetworkopen.2025.33193. PMID- 40985589 OWN - NLM STAT- MEDLINE DCOM- 20250923 LR - 20250925 IS - 1419-8711 (Print) IS - 1419-8711 (Linking) VI - 27 IP - 3 DP - 2025 Sep TI - The Hungarian Adaptation of the Parent Eating Disorder Examination Questionnaire. PG - 169-184 AB - AIM: It is recommended to consider multiple sources of information when assessing eating disorder symptoms in adolescents. The Parent Eating Disorder Examination Questionnaire (PEDE-Q) measures the parent-reported eating disorder symptoms of adolescents. The aim of the present study was to validate the Hungarian version of the PEDE-Q in a community- based Hungarian sample. Our further aim was to examine the relationship between the questionnaire and adolescents' self-reported eating disorder symptoms, as well as parents' own eating attitudes. METHOD: 201 parents aged between 32 and 68 years (155 mothers) completed the PEDE-Q and the Eating Attitudes Test-26. Additionally, 195 adolescents aged between 12 and 18 years (55.7% girls) completed the self-administered Psychiatric Scales for Children and Adolescents - Psychogenic Eating Scale. We conducted confirmatory factor analyses to examine the factor structure of the Hungarian PEDE-Q. For further bivariate analyses, we used Pearson correlations. RESULTS: After adding modification indices, the revised hierarchical model, where the three first-order factors (Restraint, Eating Concern, and Shape/Weight Concern) loaded onto a second-order general eating disorder factor, showed acceptable properties (CFI = 1.000, TLI = 0.999, RMSEA = 0.031 [90% CI: 0.017-0.042], SRMR = 0.084; alpha = 0.83-0.94). A moderate positive correlation was found between the self-reported and the parent-reported adolescent eating disorder symptoms. The results also showed a weak positive correlation between the parent-reported adolescent symptoms and the parents' own symptoms. CONCLUSION: The Hungarian Parent Eating Disorder Examination Questionnaire is a valid and reliable measure of parent-reported eating disorder symptoms of adolescents. The association between adolescent and parental reports highlights the importance of multi- informant assessments in identifying eating disorder symptoms in youth. (Neuropsychopharmacol Hung 2025; 27(3): 169-184) FAU - Rabavolgyi, Nora AU - Rabavolgyi N AD - Eotvos Lorand Tudomanyegyetem Pszichologiai Intezet, Fejlodes- es Klinikai Gyermekpszichologia Tanszek, Budapest. FAU - Nemeth, Kitti AU - Nemeth K AD - Bobai Evangelikus Egyhazkozseg, Boba. FAU - Drury, Catherine R AU - Drury CR AD - Department of Psychiatry and Behavioral Sciences, University of California, San Francisco. FAU - Szabo, Brigitta AU - Szabo B AD - Eotvos Lorand Tudomanyegyetem Pszichologiai Intezet, Fejlodes- es Klinikai Gyermekpszichologia Tanszek, Budapest. AD - Semmelweis Egyetem Klinikai, Pszichiatriai es Pszichoterapias Klinika, Pszichologia Tanszek, Budapest. LA - eng PT - Journal Article PT - Validation Study TT - A Szuloi Etkezesi Zavar Vizsgalat Kerdoiv magyar adaptacioja. PL - Hungary TA - Neuropsychopharmacol Hung JT - Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology JID - 100961631 SB - IM MH - Humans MH - Female MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Hungary MH - Adolescent MH - Male MH - Surveys and Questionnaires/standards MH - Adult MH - *Parents/psychology MH - Child MH - Middle Aged MH - Aged MH - Reproducibility of Results MH - Psychometrics MH - Self Report MH - Factor Analysis, Statistical MH - Feeding Behavior/psychology OTO - NOTNLM OT - eating OT - eating attitudes OT - eating disorders OT - adolescent EDAT- 2025/09/23 12:46 MHDA- 2025/09/23 12:47 CRDT- 2025/09/23 08:34 PHST- 2025/09/23 12:47 [medline] PHST- 2025/09/23 12:46 [pubmed] PHST- 2025/09/23 08:34 [entrez] PST - ppublish SO - Neuropsychopharmacol Hung. 2025 Sep;27(3):169-184. PMID- 40984675 OWN - NLM STAT- MEDLINE DCOM- 20250923 LR - 20250923 IS - 1099-0879 (Electronic) IS - 1063-3995 (Linking) VI - 32 IP - 5 DP - 2025 Sep-Oct TI - Parent-Focused Group Schema Coaching; CAREFREE (Carers Programme for Fluency in Resonance and Empowerment in Eating Disorders) Intervention for Parents of Adolescents With Anorexia Nervosa: A Multiple Baseline Design. PG - e70157 LID - 10.1002/cpp.70157 [doi] AB - Although family-based interventions are effective for adolescents with anorexia nervosa (AN), they often neglect the intense emotional burden faced by parents, which may limit their full therapeutic impact. This study aimed to pilot the CAREFREE parent-focused schema coaching programme and evaluate its feasibility, acceptability and preliminary effects on parental emotion regulation, parent-child interaction and adolescent AN outcomes. A three-tiered non-concurrent multiple baseline design was employed. Participants were Iranian mothers (M = 44.7 years, SD = 2.19) of female adolescents with AN (M = 15.16 years, SD = 5.54) enrolled in the 12-week online CAREFREE intervention. Outcomes were assessed at four time points using validated measures of parental difficulties in emotion regulation (DERS-16), parent-child interaction (PACHIQ-R) and adolescent percentage of median body mass index (%mBMI), alongside weekly visual analogue scales (VAS) assessing parental guilt, anger management, empathy and emotional presence. Feasibility, acceptability, and intervention fidelity were evaluated. Data were analysed in R software using visual inspection, non-overlap indices and linear mixed-effects modelling. Significant improvements were observed in all parental outcomes, including guilt, anger management, empathy, emotional presence, difficulties in emotion regulation and parent-child interaction, with effects maintained at follow-up. Adolescents' %mBMI significantly increased, whereas no significant changes were found in their body image-related outcomes. Feasibility and acceptability were supported by acceptable completion rates and high parent satisfaction. The CAREFREE intervention was feasible and acceptable and showed promising effects on parental functioning and adolescent weight outcomes. However, future research should incorporate direct adolescent-focused components, and larger controlled trials are required to more rigorously assess the intervention's impact. Trial Registration: Iranian Registry of Clinical Trials: IRCT20220714055467N1. CI - (c) 2025 John Wiley & Sons Ltd. FAU - Seifi, Fatemeh AU - Seifi F AUID- ORCID: 0000-0001-6021-5685 AD - Department of Clinical Psychology, Shiraz University, Shiraz, Iran. AD - Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. FAU - Molazadeh, Javad AU - Molazadeh J AUID- ORCID: 0000-0001-6193-8906 AD - Department of Clinical Psychology, Shiraz University, Shiraz, Iran. FAU - Aflakseir, Abdulaziz AU - Aflakseir A AUID- ORCID: 0000-0002-6926-363X AD - Department of Clinical Psychology, Shiraz University, Shiraz, Iran. FAU - Taghanaki, Changiz Rahimi AU - Taghanaki CR AUID- ORCID: 0000-0002-7180-364X AD - Department of Clinical Psychology, Shiraz University, Shiraz, Iran. FAU - Simpson, Susan AU - Simpson S AUID- ORCID: 0000-0002-9625-0797 AD - Livilands Resource Centre, NHS Forth Valley Eating Disorders Service, Stirling, UK. AD - Department of Justice and Society, University of South Australia, Adelaide, Australia. LA - eng PT - Journal Article PL - England TA - Clin Psychol Psychother JT - Clinical psychology & psychotherapy JID - 9416196 SB - IM MH - Humans MH - Female MH - *Anorexia Nervosa/therapy/psychology MH - Adolescent MH - *Parent-Child Relations MH - Adult MH - Iran MH - Pilot Projects MH - Feasibility Studies MH - *Family Therapy/methods MH - *Mentoring/methods MH - *Parents/psychology MH - *Psychotherapy, Group/methods MH - Treatment Outcome MH - Emotional Regulation MH - *Mothers/psychology OTO - NOTNLM OT - adolescents OT - anorexia nervosa OT - parents OT - schema coaching EDAT- 2025/09/23 06:36 MHDA- 2025/09/23 06:37 CRDT- 2025/09/23 02:03 PHST- 2025/09/04 00:00 [revised] PHST- 2025/07/09 00:00 [received] PHST- 2025/09/09 00:00 [accepted] PHST- 2025/09/23 06:37 [medline] PHST- 2025/09/23 06:36 [pubmed] PHST- 2025/09/23 02:03 [entrez] AID - 10.1002/cpp.70157 [doi] PST - ppublish SO - Clin Psychol Psychother. 2025 Sep-Oct;32(5):e70157. doi: 10.1002/cpp.70157. PMID- 40982839 OWN - NLM STAT- MEDLINE DCOM- 20250922 LR - 20250928 IS - 0353-5053 (Print) IS - 0353-5053 (Linking) VI - 37 IP - Suppl 1 DP - 2025 Sep TI - PSYCHOTIC SYMPTOMS IN ANOREXIA NERVOSA. PG - 288-293 AB - BACKGROUND: Recent studies suggest an overlap and mutual influence between Anorexia Nervosa (AN) and psychotic symptoms, with the anorexic voice proposed as a clinically significant marker within this spectrum. This cross-sectional observational study aimed to assess the prevalence and characteristics of psychotic symptoms, focusing on the anorexic voice, in patients with AN. Secondary objectives included exploring associations with dissociation, body image disturbance (BID), sociodemographic and clinical factors. SUBJECTS AND METHODS: Forty-three patients were recruited from specialized outpatient and inpatient Services. Anamnestic history was collected, participants completed psychometric assessments, including Positive and Negative Syndrome Scale (PANSS), Brown Assessment of Beliefs Scale (BABS/BABS-A), Eating Disorder Examination (EDE-Q), Eating Disorder Inventory (EDI-3), Body Uneasiness Test (BUT), Body Shape Questionnaire (BSQ), Symptom Checklist-90 Revised (SCL-90-R), Dissociative Experience Scale (DES/A-DES), Community Assessment of Psychic Experiences (CAPE-42), Multidimensional Assessment of Interoceptive Awareness (MAIA). RESULTS: The anorexic voice was significantly associated with clinically relevant dissociation, not with BID. Subthreshold psychotic symptoms were common and significantly linked to body dissatisfaction, eating psychopathology and dissociation. Psychoticism was associated with BID, higher psychiatric comorbidity (especially personality and anxiety disorders), lower ideal BMI and greater general psychopathology. Adolescents showed higher levels of persecutory ideation, interpersonal alienation and general psychopathology. CONCLUSIONS: Psychotic-like symptoms are highly prevalent in AN. The anorexic voice appears more closely related to dissociative processes than psychotic phenomena. Conversely, BID may play a significant role in the onset of predominant ideation about body shape and weight. Larger longitudinal studies are needed to clarify these relationships and their prognostic implications. FAU - Chieppa, Anastasia Grazia AU - Chieppa AG AD - Section of Psychiatry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy. FAU - Bellucci, Francesca AU - Bellucci F AD - Section of Psychiatry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy. FAU - Moretti, Patrizia AU - Moretti P AD - Section of Psychiatry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy. FAU - Raspa, Veronica AU - Raspa V AD - Section of Psychiatry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy. FAU - Tortorella, Alfonso AU - Tortorella A AD - Section of Psychiatry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy. LA - eng PT - Journal Article PT - Observational Study PL - Croatia TA - Psychiatr Danub JT - Psychiatria Danubina JID - 9424753 SB - IM MH - Humans MH - *Anorexia Nervosa/psychology/epidemiology MH - Female MH - *Psychotic Disorders/epidemiology/psychology/diagnosis MH - Cross-Sectional Studies MH - Adolescent MH - Adult MH - Male MH - Young Adult MH - Body Image/psychology MH - Comorbidity MH - Dissociative Disorders/epidemiology/psychology MH - Hallucinations/epidemiology OTO - NOTNLM OT - anorexia nervosa OT - anorexic voice OT - psychiatric comorbidity OT - psychotic symptoms OT - socio-demographic EDAT- 2025/09/22 18:36 MHDA- 2025/09/22 18:37 CRDT- 2025/09/22 17:03 PHST- 2025/09/22 18:37 [medline] PHST- 2025/09/22 18:36 [pubmed] PHST- 2025/09/22 17:03 [entrez] PST - ppublish SO - Psychiatr Danub. 2025 Sep;37(Suppl 1):288-293. PMID- 40981194 OWN - NLM STAT- MEDLINE DCOM- 20250922 LR - 20260702 IS - 2076-3271 (Electronic) IS - 2076-3271 (Linking) VI - 13 IP - 3 DP - 2025 Sep 17 TI - Self-Perceived Health Status and Life Satisfaction Associated with Emotional Eating in Nursing and Medical Students: A Cross-Sectional Study in a Region of Peru. LID - 10.3390/medsci13030196 [doi] LID - 196 AB - Background: Emotional eating (EmE) is a maladaptive eating behavior that has been frequently observed among university students, possibly due to academic stress and lifestyle changes. However, its specific assessment in health science students has been poorly addressed, even though this population faces high levels of academic stress and emotional burden. Objective: This study explores the association between self-perceived health status, life satisfaction, and EmE among university students in the health field on the north coast of Peru. Methods: A cross-sectional study was conducted on a sample of 1213 students. Self-perceived health, life satisfaction, and EmE were assessed using validated instruments. In addition, sociodemographic data were considered as covariates and possible confounding factors. T-tests, chi-square tests, and Poisson regression with robust variance were applied. Results: EmE was more prevalent in women (78.0%) than in men (66.8%; p < 0.001). In addition, an inverse association was observed between self-perceived health and emotional eating: students with average self-perceived health (adjusted OR = 0.88; 95% CI: 0.83-0.94) and those with high self-perceived health (adjusted OR = 0.75; 95% CI: 0.69-0.81) showed a progressively lower prevalence of EmE compared to those with low self-perceived health. Similarly, high life satisfaction was associated with a lower prevalence of EmE (adjusted PR = 0.88; 95% CI: 0.80-0.96). Conclusions: Low self-perceived health and life dissatisfaction were significantly associated with a higher probability of EmE in medical and nursing students. These results highlight the need to strengthen university programs on mental health, emotional regulation, and subjective well-being promotion as strategies to prevent maladaptive eating behaviors in academic settings, considering gender. FAU - Saintila, Jacksaint AU - Saintila J AD - Research Group for Nutrition and Healthy Behaviors, School of Medicine, Universidad Senor de Sipan, Chiclayo, Carretera a Pimentel Km 5, Lambayeque 14001, Peru. FAU - Valle-Chafloque, Ana AU - Valle-Chafloque A AUID- ORCID: 0000-0001-7265-8766 AD - Research Group for Nutrition and Healthy Behaviors, School of Medicine, Universidad Senor de Sipan, Chiclayo, Carretera a Pimentel Km 5, Lambayeque 14001, Peru. FAU - Barreto-Espinoza, Luz A AU - Barreto-Espinoza LA AD - Research Group for Nutrition and Healthy Behaviors, School of Medicine, Universidad Senor de Sipan, Chiclayo, Carretera a Pimentel Km 5, Lambayeque 14001, Peru. AD - School of Nursing, Faculty of Sciences Health, Universidad Senor de Sipan, Chiclayo, Carretera a Pimentel Km 5, Lambayeque 14001, Peru. FAU - Lopez-Lopez, Elmer AU - Lopez-Lopez E AD - Research Group for Nutrition and Healthy Behaviors, School of Medicine, Universidad Senor de Sipan, Chiclayo, Carretera a Pimentel Km 5, Lambayeque 14001, Peru. FAU - Galvez-Diaz, Norma Del Carmen AU - Galvez-Diaz NDC AD - Research Group for Nutrition and Healthy Behaviors, School of Medicine, Universidad Senor de Sipan, Chiclayo, Carretera a Pimentel Km 5, Lambayeque 14001, Peru. AD - School of Nursing, Faculty of Sciences Health, Universidad Senor de Sipan, Chiclayo, Carretera a Pimentel Km 5, Lambayeque 14001, Peru. FAU - Lizarraga-De-Maguina, Isabel G AU - Lizarraga-De-Maguina IG AD - Research Group for Nutrition and Healthy Behaviors, School of Medicine, Universidad Senor de Sipan, Chiclayo, Carretera a Pimentel Km 5, Lambayeque 14001, Peru. AD - School of Nursing, Faculty of Sciences Health, Universidad Senor de Sipan, Chiclayo, Carretera a Pimentel Km 5, Lambayeque 14001, Peru. FAU - Cervera, Noemi Alejandrina Buenano AU - Cervera NAB AD - Research Group for Nutrition and Healthy Behaviors, School of Medicine, Universidad Senor de Sipan, Chiclayo, Carretera a Pimentel Km 5, Lambayeque 14001, Peru. AD - School of Nursing, Faculty of Sciences Health, Universidad Senor de Sipan, Chiclayo, Carretera a Pimentel Km 5, Lambayeque 14001, Peru. FAU - Oblitas-Guerrero, Susan M AU - Oblitas-Guerrero SM AD - Research Group for Nutrition and Healthy Behaviors, School of Medicine, Universidad Senor de Sipan, Chiclayo, Carretera a Pimentel Km 5, Lambayeque 14001, Peru. AD - School of Nursing, Faculty of Sciences Health, Universidad Senor de Sipan, Chiclayo, Carretera a Pimentel Km 5, Lambayeque 14001, Peru. FAU - Bernal-Corrales, Fatima Del Carmen AU - Bernal-Corrales FDC AUID- ORCID: 0000-0002-0930-1403 AD - Research Group for Nutrition and Healthy Behaviors, School of Medicine, Universidad Senor de Sipan, Chiclayo, Carretera a Pimentel Km 5, Lambayeque 14001, Peru. AD - School of Nursing, Faculty of Sciences Health, Universidad Senor de Sipan, Chiclayo, Carretera a Pimentel Km 5, Lambayeque 14001, Peru. FAU - Tavara, Giovanna Larrain AU - Tavara GL AD - Research Group for Nutrition and Healthy Behaviors, School of Medicine, Universidad Senor de Sipan, Chiclayo, Carretera a Pimentel Km 5, Lambayeque 14001, Peru. AD - School of Nursing, Faculty of Sciences Health, Universidad Senor de Sipan, Chiclayo, Carretera a Pimentel Km 5, Lambayeque 14001, Peru. LA - eng GR - Article processing charge (APC)/Universidad Senor de Sipan/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250917 PL - Switzerland TA - Med Sci (Basel) JT - Medical sciences (Basel, Switzerland) JID - 101629322 SB - IM MH - Humans MH - Female MH - Male MH - Peru/epidemiology MH - *Personal Satisfaction MH - Cross-Sectional Studies MH - *Health Status MH - *Students, Medical/psychology MH - *Students, Nursing/psychology MH - Young Adult MH - *Emotions MH - Adult MH - *Self Concept MH - *Feeding Behavior/psychology MH - Adolescent MH - Emotional Eating PMC - PMC12452529 OTO - NOTNLM OT - emotional regulation OT - feeding behavior OT - health status OT - mental health OT - personal satisfaction OT - universities COIS- The authors declare no conflicts of interest. EDAT- 2025/09/22 12:45 MHDA- 2025/09/22 12:46 PMCR- 2025/09/17 CRDT- 2025/09/22 08:53 PHST- 2025/05/29 00:00 [received] PHST- 2025/07/21 00:00 [revised] PHST- 2025/08/11 00:00 [accepted] PHST- 2025/09/22 12:46 [medline] PHST- 2025/09/22 12:45 [pubmed] PHST- 2025/09/22 08:53 [entrez] PHST- 2025/09/17 00:00 [pmc-release] AID - medsci13030196 [pii] AID - medsci-13-00196 [pii] AID - 10.3390/medsci13030196 [doi] PST - epublish SO - Med Sci (Basel). 2025 Sep 17;13(3):196. doi: 10.3390/medsci13030196. PMID- 40981158 OWN - NLM STAT- MEDLINE DCOM- 20250922 LR - 20260702 IS - 2076-3271 (Electronic) IS - 2076-3271 (Linking) VI - 13 IP - 3 DP - 2025 Sep 1 TI - Diagnostic Accuracy of Anthropometric and Metabolic Indicators for Predicting MASLD: Evidence from a Large Cohort of Spanish Workers Using FLI and LAP. LID - 10.3390/medsci13030160 [doi] LID - 160 AB - BACKGROUND: Metabolic-dysfunction-associated steatotic liver disease (MASLD) is a major global health concern associated with insulin resistance, metabolic syndrome, and cardiovascular morbidity. Early identification of at-risk individuals through simple, non-invasive methods is essential, particularly in working populations. OBJECTIVES: This study aimed to assess and compare the diagnostic accuracy of four widely used anthropometric and metabolic indicators-body mass index (BMI), waist-to-height ratio (WtHR), triglyceride-glucose index (TyG), and waist-triglyceride index (WTI)-in identifying individuals at risk of metabolic-dysfunction-associated steatotic liver disease (MASLD), as determined by the Fatty Liver Index (FLI) and the Lipid Accumulation Product (LAP), within a large sample of Spanish workers. METHODS: A cross-sectional analysis was performed on data from 386,924 Spanish employees aged between 18 and 69 years. Standardized anthropometric and laboratory measurements were obtained as part of routine occupational medical examinations conducted from 2021 to 2023. The presence of NAFLD was inferred using two validated surrogate markers: FLI and LAP. Receiver operating characteristic (ROC) curves and area under the curve (AUC) values were used to assess the discriminatory ability of each index, stratified by sex. RESULTS: WTI and TyG demonstrated the highest diagnostic accuracy for both FLI- and LAP-defined NAFLD, with AUC values >0.95 in both sexes. WTI showed the best overall performance, followed closely by TyG. WtHR outperformed BMI but was less accurate than the metabolic indices. Sex-stratified analyses confirmed consistent patterns, with slightly higher AUCs for TyG and WTI in women. BMI consistently yielded the lowest discriminatory performance. CONCLUSIONS: WTI and TyG are superior to BMI and WtHR for non-invasive screening of MASLD in occupational settings. Their simplicity, low cost, and strong predictive value support their integration into routine workplace health surveillance. Sex-specific thresholds and prospective validation are warranted to enhance clinical application. FAU - Guarro Miguel, Juan Jose AU - Guarro Miguel JJ AD - ADEMA-Health Group, University Institute for Research in Health Sciences (IUNICS), 07010 Palma, Spain. FAU - Tarraga Lopez, Pedro Juan AU - Tarraga Lopez PJ AUID- ORCID: 0000-0002-5222-5784 AD - Faculty of Medicine, UCLM (University of Castilla La Mancha), 02008 Albacete, Spain. AD - SESCAM (Health Service of Castilla La Mancha), 02008 Albacete, Spain. FAU - Marzoa Jansana, Maria Dolores AU - Marzoa Jansana MD AD - ADEMA-Health Group, University Institute for Research in Health Sciences (IUNICS), 07010 Palma, Spain. FAU - Lopez-Gonzalez, Angel Arturo AU - Lopez-Gonzalez AA AUID- ORCID: 0000-0002-7439-8117 AD - ADEMA-Health Group, University Institute for Research in Health Sciences (IUNICS), 07010 Palma, Spain. AD - Faculty of Dentistry, University School ADEMA, 07010 Palma, Spain. AD - Balearic Islands Health Research Institute Foundation (IDISBA), 07010 Palma, Spain. AD - Balearic Islands Health Service, 07010 Palma, Spain. FAU - Riutord Sbert, Pere AU - Riutord Sbert P AD - ADEMA-Health Group, University Institute for Research in Health Sciences (IUNICS), 07010 Palma, Spain. AD - Faculty of Dentistry, University School ADEMA, 07010 Palma, Spain. FAU - Busquets-Cortes, Carla AU - Busquets-Cortes C AUID- ORCID: 0000-0001-9367-2137 AD - ADEMA-Health Group, University Institute for Research in Health Sciences (IUNICS), 07010 Palma, Spain. AD - Faculty of Dentistry, University School ADEMA, 07010 Palma, Spain. FAU - Ramirez-Manent, Jose Ignacio AU - Ramirez-Manent JI AUID- ORCID: 0000-0001-6887-4562 AD - ADEMA-Health Group, University Institute for Research in Health Sciences (IUNICS), 07010 Palma, Spain. AD - Balearic Islands Health Research Institute Foundation (IDISBA), 07010 Palma, Spain. AD - Balearic Islands Health Service, 07010 Palma, Spain. AD - Faculty of Medicine, University of the Balearic Islands, 07010 Palma, Spain. LA - eng PT - Journal Article DEP - 20250901 PL - Switzerland TA - Med Sci (Basel) JT - Medical sciences (Basel, Switzerland) JID - 101629322 RN - 0 (Triglycerides) SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Middle Aged MH - Spain/epidemiology MH - Body Mass Index MH - Cross-Sectional Studies MH - Young Adult MH - Aged MH - Adolescent MH - Triglycerides/blood MH - *Anthropometry/methods MH - ROC Curve MH - *Fatty Liver/diagnosis MH - *Lipid Accumulation Product MH - Metabolic Syndrome MH - Waist-Height Ratio MH - *Non-alcoholic Fatty Liver Disease/diagnosis MH - Cohort Studies PMC - PMC12452397 OTO - NOTNLM OT - Metabolic-dysfunction-associated steatotic liver disease OT - mediterranean diet OT - physical activity OT - triglyceride-glucose index OT - waist-triglyceride index COIS- The authors declare no conflicts of interest related to this work. EDAT- 2025/09/22 12:46 MHDA- 2025/09/22 12:47 PMCR- 2025/09/01 CRDT- 2025/09/22 08:52 PHST- 2025/07/28 00:00 [received] PHST- 2025/08/19 00:00 [revised] PHST- 2025/08/27 00:00 [accepted] PHST- 2025/09/22 12:47 [medline] PHST- 2025/09/22 12:46 [pubmed] PHST- 2025/09/22 08:52 [entrez] PHST- 2025/09/01 00:00 [pmc-release] AID - medsci13030160 [pii] AID - medsci-13-00160 [pii] AID - 10.3390/medsci13030160 [doi] PST - epublish SO - Med Sci (Basel). 2025 Sep 1;13(3):160. doi: 10.3390/medsci13030160. PMID- 40980178 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250922 LR - 20250924 IS - 2297-055X (Print) IS - 2297-055X (Electronic) IS - 2297-055X (Linking) VI - 12 DP - 2025 TI - A prediction model of superimposed preeclampsia in women with chronic hypertension. PG - 1641662 LID - 10.3389/fcvm.2025.1641662 [doi] LID - 1641662 AB - OBJECTIVE: The incidence of chronic hypertension (CH) with superimposed preeclampsia (PE) is 5-6 times higher than that in non-CH pregnancies, with earlier onset, higher rates of multi-organ dysfunction, and poorer maternal/fetal outcomes, yet lacks dedicated screening tools. The purpose of this study is to establish and validate a prediction model for CH with superimposed PE. METHODS: A retrospective case-control study was conducted on 471 CH patients admitted to the Tongzhou Maternal and Child Health Care Hospital of Beijing from January 2020 to December 2023. The patients were divided into superimposed preeclampsia (SPE) group (161 cases) and non-preeclampsia (NPE) group (310 cases) based on whether they had complicated PE. The patients were randomly divided into training set and validation set in a 7:3 ratio. General and clinical data were collected, and single-and multi-factor logistic regression analysis were used to screen for independent factors affecting PE in the training set. Based on the screening results, the diagnostic efficacy of PE was evaluated using the receiver operating characteristic curve. Risk prediction nomogram model was constructed using R language. The Bootstrap method was used to validate and produce calibration plots; the decision curve analysis (DCA) was used to assess the clinical benefit rate of the model. RESULTS: The results of single factor and further multi-factor analysis showed that peripheral blood levels of direct bilirubin (DBIL), gamma-glutamyl transferase (GGT), glucose (GLU), cystatin-C (CysC) and pre-pregnancy body mass index (BMI) were independent influences on the occurrence of PE (P < 0.05). The area under the curve of the combined of DBIL, GGT, GLU, CysC and pre-pregnancy BMI was 0.789, with a sensitivity of 0.593 and a specificity of 0.830, which is better than a single clinical diagnostic indicator. The results of multifactor analysis were constructed as a nomogram model, and the mean absolute error of the calibration curve of the modeling set was 0.035, suggesting that the predictive probability of the model was generally compatible with the actual value. DCA showed the predictive model has clinical utility value. CONCLUSIONS: The occurrence of PE in women with CH is related to the peripheral blood levels of DBIL, GGT, GLU, CysC and pre-pregnancy BMI, and the combination of these indexes has a better clinical diagnostic value than a single index. The nomogram model constructed by using the above indicators can be used for the prediction of PE and has high predictive efficacy. CI - (c) 2025 Lu, Yang, Li, Kuai, Tian and Zhang. FAU - Lu, Yongjun AU - Lu Y AD - Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China. AD - Tianjin Key Laboratory of Female Reproductive Health and Eugenics, Tianjin Medical University General Hospital, Tianjin, China. AD - Department of Obstetrics and Gynecology, Tongzhou Maternal & Child Health Care Hospital of Beijing, Beijing, China. FAU - Yang, Li AU - Yang L AD - Department of Obstetrics and Gynecology, Tongzhou Maternal & Child Health Care Hospital of Beijing, Beijing, China. FAU - Li, Xiaoyan AU - Li X AD - Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China. AD - Tianjin Key Laboratory of Female Reproductive Health and Eugenics, Tianjin Medical University General Hospital, Tianjin, China. FAU - Kuai, Dan AU - Kuai D AD - Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China. AD - Tianjin Key Laboratory of Female Reproductive Health and Eugenics, Tianjin Medical University General Hospital, Tianjin, China. FAU - Tian, Wenyan AU - Tian W AD - Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China. AD - Tianjin Key Laboratory of Female Reproductive Health and Eugenics, Tianjin Medical University General Hospital, Tianjin, China. FAU - Zhang, Huiying AU - Zhang H AD - Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China. AD - Tianjin Key Laboratory of Female Reproductive Health and Eugenics, Tianjin Medical University General Hospital, Tianjin, China. LA - eng PT - Journal Article DEP - 20250904 PL - Switzerland TA - Front Cardiovasc Med JT - Frontiers in cardiovascular medicine JID - 101653388 PMC - PMC12443772 OTO - NOTNLM OT - chronic hypertension OT - cystatin-C OT - direct bilirubin OT - pre-pregnancy body mass index OT - preeclampsia COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/09/22 12:46 MHDA- 2025/09/22 12:47 PMCR- 2025/09/04 CRDT- 2025/09/22 08:20 PHST- 2025/06/05 00:00 [received] PHST- 2025/08/19 00:00 [accepted] PHST- 2025/09/22 12:47 [medline] PHST- 2025/09/22 12:46 [pubmed] PHST- 2025/09/22 08:20 [entrez] PHST- 2025/09/04 00:00 [pmc-release] AID - 10.3389/fcvm.2025.1641662 [doi] PST - epublish SO - Front Cardiovasc Med. 2025 Sep 4;12:1641662. doi: 10.3389/fcvm.2025.1641662. eCollection 2025. PMID- 40978234 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250922 LR - 20250924 IS - 2279-9028 (Print) IS - 2279-9036 (Electronic) IS - 2279-9028 (Linking) VI - 14 IP - 3 DP - 2025 Jul TI - Adolescent health knowledge and awareness: A comparative study of India and the United States. PG - 22799036251373014 LID - 10.1177/22799036251373014 [doi] LID - 22799036251373014 AB - INTRODUCTION: Non-communicable diseases (NCDs) cause 71% of global deaths, with many risk factors originating in childhood. Understanding adolescent health knowledge and behaviors across countries is essential for targeted public health interventions. This study compares health literacy, dietary habits, physical activity, mental health awareness, sexual health education, and substance use awareness between adolescents in India and the United States (US). DESIGN AND METHODS: A cross-sectional survey was conducted among 200 adolescents (100 per country) recruited through educational institutions and online platforms. Stratified sampling ensured representation across age (13-18 years), gender, and geographic location (urban vs rural). A structured questionnaire, adapted from validated instruments, assessed health-related behaviors and knowledge. Descriptive statistics and chi-square tests compared responses, and logistic regression adjusted for confounders. RESULTS: Significant differences emerged between Indian and US adolescents. Indian respondents had lower mental health awareness (46% vs 88%, p = 0.0004) and Sexually Transmitted Infection (STI) prevention knowledge (58% vs 77%, p < 0.0001). Regular physical activity was higher in the US (50% vs 20%, p < 0.0001), as was nutrition awareness (83% vs 69%, p = 0.0152). Indian adolescents more often relied on school-based health education (29% vs 21%) and social media (30% vs 29%) for information. CONCLUSION: Findings highlight disparities in adolescent health literacy and behaviors across India and the US. Public health efforts should prioritize mental health literacy, nutrition education, and physical activity, especially in India. Digital platforms and school-based initiatives can help bridge knowledge gaps and promote healthier adolescent behaviors globally. CI - (c) The Author(s) 2025. FAU - Abdul Majeed, Ahsan Kaja AU - Abdul Majeed AK AUID- ORCID: 0009-0007-0764-1344 AD - Care International School, Tiruchirappalli, Tamil Nadu, India. FAU - Raj, Jay AU - Raj J AD - The Village School, Houston, TX, USA. LA - eng PT - Journal Article DEP - 20250919 PL - United States TA - J Public Health Res JT - Journal of public health research JID - 101580775 PMC - PMC12449629 OTO - NOTNLM OT - adolescent health OT - cross-national survey OT - mental health awareness OT - nutrition education OT - physical activity COIS- The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/09/22 12:46 MHDA- 2025/09/22 12:47 PMCR- 2025/09/19 CRDT- 2025/09/22 07:45 PHST- 2025/04/06 00:00 [received] PHST- 2025/08/10 00:00 [accepted] PHST- 2025/09/22 12:47 [medline] PHST- 2025/09/22 12:46 [pubmed] PHST- 2025/09/22 07:45 [entrez] PHST- 2025/09/19 00:00 [pmc-release] AID - 10.1177_22799036251373014 [pii] AID - 10.1177/22799036251373014 [doi] PST - epublish SO - J Public Health Res. 2025 Sep 19;14(3):22799036251373014. doi: 10.1177/22799036251373014. eCollection 2025 Jul. PMID- 40977989 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250922 LR - 20250924 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - Validity and predictability of mid-upper arm circumference for nutrition screening in outpatient preschoolers with cerebral palsy. PG - 1609032 LID - 10.3389/fnut.2025.1609032 [doi] LID - 1609032 AB - AIM: Evaluating the nutritional status of children with cerebral palsy (CP) is difficult due to spasticity and contractures. Mid-upper arm circumference (MUAC) is a potential screening tool for malnutrition in children with CP, but its effectiveness is unproven. This study aims to provide evidence on the psychometric qualities of MUAC for clinical use and establish optimal cutoffs for preschoolers with CP. METHODS: Children with CP aged 12-60 months (n = 937) were recruited from 24 hospitals across 13 provinces in China for the cross-sectional study, while those had genetic or metabolic diseases were excluded. Weight, length/height and MUAC were obtained from participants. Weight and length/height were calculated into Z scores by using WHO Anthro software to assess the nutritional status. The sensitivity and specificity of the WHO-recommended MUAC cutoffs were calculated. The Spearman's rank correlation, Receiver operating characteristic (ROC) curve, and Youden Index were conducted to establish the optimal MUAC cutoffs for preschoolers with CP. RESULTS: Compared to Z score cutoffs, WHO-recommended MUAC cutoffs showed high specificity but low sensitivity for malnutrition. MUAC significantly correlated with weight-for-length/height Z score (r = 0.606), weight-for-age Z score (r = 0.557), length/height-for-age Z score (r = 0.276), and BMI-for-age Z score (r = 0.575). The optimal MUAC cutoffs for mild, moderate, and severe undernutrition were 15.35, 15.05, and 14.35 cm, respectively; the optimal cutoffs for overweight and obesity were 17.55 and 20.4 cm, respectively. CONCLUSION: Our study suggests that MUAC is a useful tool for screening the nutritional status of children with CP. However, the WHO-recommended MUAC cut-off may not be suitable for preschool with CP. We estimated that the optimal MUAC cutoffs were 15.35 cm for mild undernutrition, 15.05 cm for moderate undernutrition, and 14.35 cm for severe undernutrition, and 17.55 cm for overweight and 20.4 cm for obesity in preschool with CP. CLINICAL TRIAL REGISTRATION: www.chictr.org.cn, ChiCTR2000033869. CI - Copyright (c) 2025 Zhou, Peng, Wei, Zhang, Zhao, Le, Fan, Qiu, Zheng, Lin, Zheng, Ma, Zhang, Li, Lu, Tang, He and Xu. FAU - Zhou, Hongyu AU - Zhou H AD - Department of Rehabilitation, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, China. FAU - Peng, Tingting AU - Peng T AD - Department of Rehabilitation, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, China. FAU - Wei, Mou AU - Wei M AD - Department of Rehabilitation, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, China. AD - Department of Neonatology, Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. FAU - Zhang, Jingbo AU - Zhang J AD - Department of Rehabilitation, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, China. FAU - Zhao, Yiting AU - Zhao Y AD - Department of Rehabilitation, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, China. FAU - Le, Wen AU - Le W AD - Department of Rehabilitation, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, China. AD - Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China. FAU - Fan, Danxia AU - Fan D AD - Department of Rehabilitation, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, China. AD - School of Nursing, Guangdong Pharmaceutical University, Guangzhou, China. FAU - Qiu, Shaihong AU - Qiu S AD - Department of Rehabilitation, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, China. FAU - Zheng, Yuai AU - Zheng Y AD - Department of Rehabilitation, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, China. FAU - Lin, Qiujin AU - Lin Q AD - Department of Rehabilitation, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, China. FAU - Zheng, Yun AU - Zheng Y AD - Department of Rehabilitation, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, China. FAU - Ma, Liying AU - Ma L AD - Department of Rehabilitation, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, China. FAU - Zhang, Jing AU - Zhang J AD - Department of Rehabilitation, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, China. FAU - Li, Jinling AU - Li J AD - Department of Rehabilitation, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, China. FAU - Lu, Jinhua AU - Lu J AD - Department of Rehabilitation, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, China. AD - Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. FAU - Tang, Hongmei AU - Tang H AD - Department of Rehabilitation, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, China. FAU - He, Lu AU - He L AD - Department of Rehabilitation, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, China. FAU - Xu, Kaishou AU - Xu K AD - Department of Rehabilitation, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, China. LA - eng PT - Journal Article DEP - 20250905 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12447903 OTO - NOTNLM OT - cerebral palsy OT - cutoffs OT - malnutrition OT - mid-upper arm circumference OT - overnutrition OT - preschoolers OT - undernutrition COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/09/22 12:46 MHDA- 2025/09/22 12:47 PMCR- 2025/09/05 CRDT- 2025/09/22 07:41 PHST- 2025/04/09 00:00 [received] PHST- 2025/08/21 00:00 [accepted] PHST- 2025/09/22 12:47 [medline] PHST- 2025/09/22 12:46 [pubmed] PHST- 2025/09/22 07:41 [entrez] PHST- 2025/09/05 00:00 [pmc-release] AID - 10.3389/fnut.2025.1609032 [doi] PST - epublish SO - Front Nutr. 2025 Sep 5;12:1609032. doi: 10.3389/fnut.2025.1609032. eCollection 2025. PMID- 40975731 OWN - NLM STAT- MEDLINE DCOM- 20260422 LR - 20261010 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) VI - 99 IP - 4 DP - 2026 Mar TI - Confirmatory-factor-analysis-derived metabolic syndrome risk score: development, validation, and clinical utility in dual adolescent populations. PG - 1375-1383 LID - 10.1038/s41390-025-04419-w [doi] AB - BACKGROUND: This study developed and validated a continuous metabolic syndrome (MetS) risk score (msRS) for adolescents and evaluated its clinical utility in identifying multiple clinical cardiovascular markers (CCMs) using dual adolescent populations. METHODS: Adolescents aged 12‒18 from two stratified random samples were used: the nationwide Nutrition and Health Survey in Taiwan (NAHSIT, n = 1920) for development and the Adiposity‒Cardiovascular Disease Axis study in Southern Taiwan (adiCards, n = 3295) for validation. Four sex-and-age-specific msRS were developed through confirmatory factor analysis (CFA) utilizing five MetS components-waist circumference, high-density lipoprotein cholesterol, triglycerides, fasting glucose, and mean arterial pressure. Their discriminatory ability for clinical outcomes was validated using the area under receiver operating characteristic (AU-ROC) curve. RESULTS: The msRS demonstrated exceptional capability in detecting MetS in NAHSIT and adiCards cohorts (AU-ROCs: 0.954‒0.969). Adjusted for covariates, msRS explained higher variability in body-fat percentage, apolipoproteins B/A1, and homeostatic model assessment of insulin resistance (HOMA-IR) than binary MetS and abnormal components count (partial R(2), 23.7‒26.8% vs 4.1‒20.7%) in the validation dataset. An increase in msRS was associated with a 1.9-, 2.7-, 3.4-, and 14.4-fold risk of elevated low-density lipoprotein cholesterol, hyperuricemia, high HOMA-IR, and >/=3 CCMs. CONCLUSION: The CFA-derived sex-and-age-adjusted msRS scheme provides an improving measure to assess and manage adolescent cardiometabolic health. IMPACT: Adolescent MetS components share a latent metabolic construct. A scoring system through confirmatory factor analysis captures sex-and-age specific metabolic heterogeneity. Continuous risk score accurately discriminates pediatric MetS. MetS risk score effectively detects pediatric cardiovascular risk. Consideration of population characteristics is essential when developing a continuous MetS score. CI - (c) 2025. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - Chin, Yu-Ting AU - Chin YT AD - Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan. FAU - Wu, Pei-Wen AU - Wu PW AD - Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan. FAU - Huang, Pin-Rui AU - Huang PR AD - Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan. FAU - Tsai, Sharon AU - Tsai S AD - Department of Laboratory Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan. FAU - Lin, Wei-Ting AU - Lin WT AD - Department of Social, Behavioral, and Population Sciences, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA. FAU - Lee, Chun-Ying AU - Lee CY AD - Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. FAU - Tsai, Wei-Chung AU - Tsai WC AD - Department of Internal Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. FAU - Lee, Chien-Hung AU - Lee CH AD - Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan. cnhung@kmu.edu.tw. AD - Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. cnhung@kmu.edu.tw. AD - Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. cnhung@kmu.edu.tw. AD - College of Professional Studies, National Pingtung University of Science and Technology, Pingtung, Taiwan. cnhung@kmu.edu.tw. LA - eng PT - Journal Article PT - Validation Study DEP - 20250920 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 RN - 0 (Biomarkers) RN - 0 (Blood Glucose) RN - 0 (Triglycerides) SB - IM MH - Humans MH - *Metabolic Syndrome/diagnosis/epidemiology MH - Adolescent MH - Male MH - Female MH - Taiwan/epidemiology MH - Child MH - Factor Analysis, Statistical MH - Risk Factors MH - Risk Assessment MH - Cardiovascular Diseases MH - Waist Circumference MH - ROC Curve MH - Reproducibility of Results MH - Nutrition Surveys MH - Biomarkers/blood MH - Blood Glucose MH - Triglycerides/blood COIS- Competing interests: The authors declare no competing interests. Consent Statement: Informed assent and consent were collected from all student participants and their guardians to ensure voluntary participation and compliance with ethical standards in both studies. The Institutional Review Board of Kaohsiung Medical University Hospital approved the study protocol (approval no. KMUHIRB-20120103). EDAT- 2025/09/21 00:30 MHDA- 2026/04/23 00:31 CRDT- 2025/09/20 23:15 PHST- 2024/11/12 00:00 [received] PHST- 2025/08/23 00:00 [accepted] PHST- 2025/07/21 00:00 [revised] PHST- 2026/04/23 00:31 [medline] PHST- 2025/09/21 00:30 [pubmed] PHST- 2025/09/20 23:15 [entrez] AID - 10.1038/s41390-025-04419-w [pii] AID - 10.1038/s41390-025-04419-w [doi] PST - ppublish SO - Pediatr Res. 2026 Mar;99(4):1375-1383. doi: 10.1038/s41390-025-04419-w. Epub 2025 Sep 20. PMID- 40974550 OWN - NLM STAT- MEDLINE DCOM- 20251113 LR - 20260515 IS - 1554-527X (Electronic) IS - 0736-0266 (Print) IS - 0736-0266 (Linking) VI - 43 IP - 12 DP - 2025 Dec TI - Longitudinal Progression of Traumatic Bone Marrow Lesions Following Anterior Cruciate Ligament Injury: Associations With Knee Pain and Concomitant Injuries. PG - 2178-2187 LID - 10.1002/jor.70067 [doi] AB - Traumatic bone marrow lesions (BMLs) occur in ~80% of anterior cruciate ligament (ACL) injuries, typically in the lateral femoral condyle (LFC) and lateral tibial plateau (LTP). Associated with microfractures, vascular proliferation, inflammation, and bone density changes, BMLs may contribute to posttraumatic osteoarthritis. However, their relationship with knee pain is unclear. This study examined the prevalence, characteristics, and progression of BMLs after ACL injury, focusing on associations with pain, meniscal and ligament injuries, and fractures. Participants (N = 100, aged 14-55) with MRI-confirmed ACL tears were scanned within 6 weeks post-injury (mean = 30.0, SD = 9.6 days). BML volumes were quantified using a validated machine learning method, and pain assessed via the Knee Injury and Osteoarthritis Outcome Score (KOOS). Analyses included t-tests, Mann-Whitney U, chi-square, and Spearman correlations with false discovery rate correction. BMLs were present in 95% of participants, primarily in the LFC and LTP. Males had 33% greater volumes than females (p < 0.05), even after adjusting for BMI. Volumes were higher in cases with depression fractures (p = 0.022) and negatively associated with baseline KOOS Symptoms. At 1 year, 92.68% of lesions (based on lesion counts) resolved in Nonsurgical participants, with a 96.13% volume reduction (p < 0.001). KOOS outcomes were similar between groups, except for slightly better Pain scores in the Nonsurgical group. Baseline Pain and Sport scores predicted follow-up outcomes. BMLs are common post-ACL injury, vary by sex and fracture status, and modestly relate to early symptoms. Most resolve within a year, with limited long-term differences by surgical status. CI - (c) 2025 The Author(s). Journal of Orthopaedic Research(R) published by Wiley Periodicals LLC on behalf of Orthopaedic Research Society. FAU - Stirling, Callie E AU - Stirling CE AD - Department of Biomedical Engineering, Schulich School of Engineering, University of Calgary, Calgary, Canada. AD - McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Canada. FAU - Pavlovic, Nina AU - Pavlovic N AD - Department of Biomedical Engineering, Schulich School of Engineering, University of Calgary, Calgary, Canada. AD - McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Canada. FAU - Manske, Sarah L AU - Manske SL AD - McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Canada. AD - Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Canada. FAU - Walker, Richard E A AU - Walker REA AD - McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Canada. AD - Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Canada. FAU - Boyd, Steven K AU - Boyd SK AUID- ORCID: 0000-0002-2930-5997 AD - Department of Biomedical Engineering, Schulich School of Engineering, University of Calgary, Calgary, Canada. AD - McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Canada. AD - Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Canada. LA - eng GR - Canadian Institutes of Health Research, PJT 162189./ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250920 PL - United States TA - J Orthop Res JT - Journal of orthopaedic research : official publication of the Orthopaedic Research Society JID - 8404726 SB - IM MH - Humans MH - Male MH - Female MH - *Anterior Cruciate Ligament Injuries/complications/diagnostic imaging MH - Adult MH - Middle Aged MH - Young Adult MH - Adolescent MH - *Bone Marrow/pathology/injuries/diagnostic imaging MH - Longitudinal Studies MH - Magnetic Resonance Imaging MH - *Arthralgia/etiology MH - Disease Progression MH - *Bone Marrow Diseases/etiology PMC - PMC12604437 OTO - NOTNLM OT - ACL OT - Bone OT - Diagnostic Imaging OT - Osteoarthritis OT - Osteoarthritis - Post Traumatic OT - Reconstruction COIS- The authors declare no conflicts of interest. EDAT- 2025/09/20 12:32 MHDA- 2025/11/13 06:29 PMCR- 2025/11/11 CRDT- 2025/09/20 11:43 PHST- 2025/08/27 00:00 [revised] PHST- 2025/06/13 00:00 [received] PHST- 2025/09/10 00:00 [accepted] PHST- 2025/11/13 06:29 [medline] PHST- 2025/09/20 12:32 [pubmed] PHST- 2025/09/20 11:43 [entrez] PHST- 2025/11/11 00:00 [pmc-release] AID - JOR70067 [pii] AID - 10.1002/jor.70067 [doi] PST - ppublish SO - J Orthop Res. 2025 Dec;43(12):2178-2187. doi: 10.1002/jor.70067. Epub 2025 Sep 20. PMID- 40972710 OWN - NLM STAT- MEDLINE DCOM- 20251210 LR - 20260331 IS - 1097-6833 (Electronic) IS - 0022-3476 (Linking) VI - 288 DP - 2026 Jan TI - Body Roundness Index is a Stronger Predictor of Cardiometabolic Risk than Body Mass Index in Children between Ages 8 to 17 years. PG - 114826 LID - S0022-3476(25)00367-1 [pii] LID - 10.1016/j.jpeds.2025.114826 [doi] AB - OBJECTIVE: To determine whether body roundness index (BRI) is a stronger predictor of cardiometabolic outcomes compared with body mass index (BMI) in children. METHODS: This cross-sectional study included 3996 children aged 8-17 from the 2015-2020 National Health and Nutrition Examination Survey database. Exposures were BMI and BRI z-scores. Primary outcomes were hypertensive blood pressure (BP) and BP index; secondary outcomes were serum glucose, insulin, and triglyceride levels. Complex regression models were adjusted for age, sex, poverty index ratio, food insecurity, and energy expenditure. RESULTS: BRI and BMI z-scores were individually associated with systolic and diastolic blood pressure indices. The addition of BRI to the BMI model strengthened the association with diastolic BP index, but not for systolic BP index. Although BMI z-scores were not associated with hypertensive BP, BRI z-scores were significantly associated with hypertensive BP (OR 1.497, 95% CI [1.175-1.907], P < .01). Adding BRI to BMI models improved the predictive fit for hypertensive BP as well as serum glucose, insulin, and triglyceride levels. CONCLUSIONS: BRI is a stronger predictor of cardiometabolic outcomes compared with BMI, providing incremental value in cardiovascular risk assessment in children. Future studies should validate these findings and explore the clinical utility of BRI in pediatric settings. CI - Copyright (c) 2025 Elsevier Inc. All rights reserved. FAU - Jahan, Afsana AU - Jahan A AD - Division of Pediatric Nephrology, Northwell Health, Cohen Children's Medical Center, New Hyde Park, NY; Feinstein Institutes for Medical Research, Manhasset, NY. FAU - Abdullah, Mahie M AU - Abdullah MM AD - Division of Pediatric Nephrology, Northwell Health, Cohen Children's Medical Center, New Hyde Park, NY; Feinstein Institutes for Medical Research, Manhasset, NY. FAU - Frank, Rachel AU - Frank R AD - Division of Pediatric Nephrology, Northwell Health, Cohen Children's Medical Center, New Hyde Park, NY; Feinstein Institutes for Medical Research, Manhasset, NY. FAU - Castellanos, Laura J AU - Castellanos LJ AD - Division of Pediatric Nephrology, Northwell Health, Cohen Children's Medical Center, New Hyde Park, NY; Feinstein Institutes for Medical Research, Manhasset, NY. FAU - Singer, Pamela AU - Singer P AD - Division of Pediatric Nephrology, Northwell Health, Cohen Children's Medical Center, New Hyde Park, NY; Feinstein Institutes for Medical Research, Manhasset, NY. FAU - Shen, Carol L AU - Shen CL AD - Division of Pediatric Nephrology, Northwell Health, Cohen Children's Medical Center, New Hyde Park, NY; Feinstein Institutes for Medical Research, Manhasset, NY. FAU - Basalely, Abby M AU - Basalely AM AD - Division of Pediatric Nephrology, Northwell Health, Cohen Children's Medical Center, New Hyde Park, NY; Feinstein Institutes for Medical Research, Manhasset, NY. FAU - Sethna, Christine B AU - Sethna CB AD - Division of Pediatric Nephrology, Northwell Health, Cohen Children's Medical Center, New Hyde Park, NY; Feinstein Institutes for Medical Research, Manhasset, NY. Electronic address: csethna@northwell.edu. LA - eng GR - R01 HL162912/HL/NHLBI NIH HHS/United States GR - R01 DK131091/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20250917 PL - United States TA - J Pediatr JT - The Journal of pediatrics JID - 0375410 RN - 0 (Blood Glucose) SB - IM MH - Humans MH - Child MH - Male MH - *Body Mass Index MH - Female MH - Adolescent MH - Cross-Sectional Studies MH - *Cardiometabolic Risk Factors MH - Nutrition Surveys MH - Blood Pressure MH - Hypertension/epidemiology MH - Blood Glucose/analysis MH - Risk Assessment OTO - NOTNLM OT - NHANES OT - cardiovascular risk OT - children OT - hypertension OT - obesity COIS- Declaration of competing interest C.B.S. is funded by NIH/NHLBI 1R01HL162912-01A1and NIH/NIDDK R01DK131091. C.L.S. reports a relationship with Nephcure Kidney International that includes funding grants. C.B.S. reports a relationship with Novo Nordisk Inc that includes: board membership. C.B.S. reports a relationship with National Institutes of Health that includes funding grants. She has served on the advisory board for Otsuka. She reports a relationship with Apellis Pharmaceuticals, Inc that includes board membership. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/09/20 00:31 MHDA- 2025/12/11 01:22 CRDT- 2025/09/19 19:12 PHST- 2025/03/18 00:00 [received] PHST- 2025/09/11 00:00 [revised] PHST- 2025/09/12 00:00 [accepted] PHST- 2025/12/11 01:22 [medline] PHST- 2025/09/20 00:31 [pubmed] PHST- 2025/09/19 19:12 [entrez] AID - S0022-3476(25)00367-1 [pii] AID - 10.1016/j.jpeds.2025.114826 [doi] PST - ppublish SO - J Pediatr. 2026 Jan;288:114826. doi: 10.1016/j.jpeds.2025.114826. Epub 2025 Sep 17. PMID- 40969438 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250919 LR - 20250921 IS - 1664-302X (Print) IS - 1664-302X (Electronic) IS - 1664-302X (Linking) VI - 16 DP - 2025 TI - Exploring the potential of zinc-solubilizing Bacillus strains to enhance rice (Oryza sativa L.) productivity in nutrient-deficit soils. PG - 1626216 LID - 10.3389/fmicb.2025.1626216 [doi] LID - 1626216 AB - INTRODUCTION: Food and nutritional security remain a significant challenge among the food-insecure people around the world, facing a lack of nutritious food rather than food availability alone. Micronutrient deficiencies in staple grains present a serious public health issue, especially impacting millions of women and children in developing nations. Staple cereals contain low concentrations of micronutrients, especially zinc (Zn). METHODOLOGY: The present study explored the potential of zinc-solubilizing Bacillus strains to improve rice (Oryza sativa L.) growth, antioxidant activity, yield, and quality in a completely randomized design (CRD) with four replications. For this purpose, four pre-isolated, characterized and identified Bacillus strains (AN24, AN30, AN31, and AN35) were evaluated separately, as well as in co-inoculation on the growth promotion of rice cultivar PK 386. RESULTS: The results showed that the co-inoculation of Bacillus strains improved the growth and yield of rice more effectively than individual bacterial strains. Furthermore, co-inoculation was also more efficient in improving the soil nutrient status and biology (microbial populations) on which rice plants were grown in the pot experiment. In addition to improvement in plant growth parameters, the co-inoculation of Bacillus strains improved the N, P, K, Fe, and Zn up to 26, 30, 29, 19, and 27%, respectively, in rice grains as compared to control, along with improvement in macro and micronutrients in rice straw and roots. Co-inoculation also improved the crude protein in rice grains by 27% compared to the un-inoculated control. DISCUSSION: These results suggest that co-inoculated Bacillus megaterium strains AN24 and B. AN31offer a promising, eco-friendly alternative to synthetic fertilizers and can play a vital role in addressing micronutrient deficiencies in cereals. FUTURE DIRECTIONS: Further molecular characterization of Zn solubilizing genes and field-scale evaluations are recommended to validate their efficacy under diverse agroecological conditions. The combination could be further evaluated as a valuable tool for developing biofertilizers to improve rice productivity and quality in nutrient-deficient soils. CI - Copyright (c) 2025 Ahmad, Naseer, Nazli, Dar, Sarfraz, Zulfiqar, El-Beltagi, Saleh, Rebouh, Rasulov and Vara Prasad. FAU - Ahmad, Maqshoof AU - Ahmad M AD - Department of Soil Science, The Islamia University of Bahawalpur, Bahawalpur, Pakistan. FAU - Naseer, Iqra AU - Naseer I AD - Department of Soil Science, The Islamia University of Bahawalpur, Bahawalpur, Pakistan. FAU - Nazli, Farheen AU - Nazli F AD - Institute of Agro-Industry and Environment, The Islamia University of Bahawalpur, Bahawalpur, Pakistan. FAU - Dar, Abubakar AU - Dar A AD - Department of Soil Science, The Islamia University of Bahawalpur, Bahawalpur, Pakistan. FAU - Sarfraz, Rubab AU - Sarfraz R AD - Institute of Agriculture and Applied Life Science, Gyeongsang National University, Jinju, Republic of Korea. FAU - Zulfiqar, Usman AU - Zulfiqar U AD - Department of Agronomy, Faculty of Agriculture and Environment, The Islamia University of Bahawalpur, Bahawalpur, Pakistan. FAU - El-Beltagi, Hossam S AU - El-Beltagi HS AD - Department of Agricultural Biotechnology, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa, Saudi Arabia. FAU - Saleh, Muneera A AU - Saleh MA AD - Department of Biology, College of Sciences, Taif University, Taif, Saudi Arabia. FAU - Rebouh, Nazih Y AU - Rebouh NY AD - Department of Environmental Management, Institute of Environmental Engineering, RUDN University, Moscow, Russia. FAU - Rasulov, Xasanboy AU - Rasulov X AD - Department of Agrochemistry and Soil Science, Tashkent State Agrarian University, Tashkent, Uzbekistan. FAU - Prasad, Pv Vara AU - Prasad PV AD - Department of Agronomy, Kansas State University, Manhattan, KS, United States. LA - eng PT - Journal Article DEP - 20250903 PL - Switzerland TA - Front Microbiol JT - Frontiers in microbiology JID - 101548977 PMC - PMC12440880 OTO - NOTNLM OT - Bacillus OT - malnutrition OT - micronutrients OT - quality OT - rice OT - soil health COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/09/19 06:32 MHDA- 2025/09/19 06:33 PMCR- 2025/09/03 CRDT- 2025/09/19 04:59 PHST- 2025/05/10 00:00 [received] PHST- 2025/08/19 00:00 [accepted] PHST- 2025/09/19 06:33 [medline] PHST- 2025/09/19 06:32 [pubmed] PHST- 2025/09/19 04:59 [entrez] PHST- 2025/09/03 00:00 [pmc-release] AID - 10.3389/fmicb.2025.1626216 [doi] PST - epublish SO - Front Microbiol. 2025 Sep 3;16:1626216. doi: 10.3389/fmicb.2025.1626216. eCollection 2025. PMID- 40968467 OWN - NLM STAT- MEDLINE DCOM- 20251117 LR - 20251119 IS - 1475-2662 (Electronic) IS - 0007-1145 (Print) IS - 0007-1145 (Linking) VI - 134 IP - 6 DP - 2025 Sep 28 TI - Development and validation of Tanzania's food literacy tool for adults: implications for healthy eating behaviours. PG - 518-528 LID - 10.1017/S0007114525105138 [doi] AB - The study aimed to develop and validate a food literacy tool for Tanzanian adults. The Tanzanian nutrition, food and health promotion experts evaluated the initial twenty-three-question food literacy tool for its relevance to the context, where its content validity was determined. The construct validity involved the analysis of food literacy information collected in a cross-sectional study involving 709 adults (484 females and 225 males) sampled from rural and urban Tanzania. Exploratory factor analysis was conducted to explore the underlying factor structure and identify the number of latent constructs. A confirmatory factor analysis using structural equation modelling verified the measurement model and confirmed the theoretical model's validity and reliability. The descriptive statistics summarised the essential characteristics of the study sample. The final tool remained with fourteen questions after removing questions with low factor loadings < 0.5 and higher uniqueness above 0.60. The model achieved construct validity through convergent and discriminant validity and construct reliability through the composite reliability exceeding 0.60 and a Cronbach's alpha value of 0.83 and above. The fourteen-question food literacy tool has been reviewed and evaluated by experts in food, nutrition and public health; therefore, it is a valid measure of food literacy among adults in Tanzania. It is suitable for designing nutrition education programmes and ensures accurate and reliable measurements for effective interventions and policy actions. FAU - Kariathi, Victoria AU - Kariathi V AUID- ORCID: 0000-0002-5004-8198 AD - Sokoine University of Agriculturehttps://ror.org/00jdryp44, Department of Human Nutrition and Consumer Sciences, P.O. Box 3006, Morogoro, Tanzania. AD - Tanzania Food and Nutrition Centre, Department of Nutrition Education and Training, P.O. Box 977, Dar es Salaam, Tanzania. FAU - Mbwana, Hadijah AU - Mbwana H AD - Sokoine University of Agriculturehttps://ror.org/00jdryp44, Department of Human Nutrition and Consumer Sciences, P.O. Box 3006, Morogoro, Tanzania. FAU - Rybak, Constance AU - Rybak C AD - Division Urban Plant Ecophysiology, Faculty of Life Sciences, Thaer-Institute of Agricultural and Horticultural Sciences, Humboldt-Universitat zu Berlin, Lentzeallee 55, 14195Berlin, Germany. FAU - Msollo, Safiness AU - Msollo S AD - Sokoine University of Agriculturehttps://ror.org/00jdryp44, Department of Human Nutrition and Consumer Sciences, P.O. Box 3006, Morogoro, Tanzania. LA - eng PT - Journal Article PT - Validation Study DEP - 20250919 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM MH - Humans MH - Tanzania MH - Male MH - Female MH - Adult MH - *Health Literacy MH - Cross-Sectional Studies MH - Reproducibility of Results MH - Middle Aged MH - *Diet, Healthy MH - Young Adult MH - Surveys and Questionnaires MH - Factor Analysis, Statistical MH - *Feeding Behavior MH - Rural Population MH - Adolescent MH - Aged MH - Health Knowledge, Attitudes, Practice PMC - PMC12623124 OTO - NOTNLM OT - Adults OT - Food OT - Food literacy OT - Nutrition information OT - Tanzania OT - Validity EDAT- 2025/09/19 06:33 MHDA- 2025/11/17 17:30 PMCR- 2025/11/17 CRDT- 2025/09/19 00:34 PHST- 2025/11/17 17:30 [medline] PHST- 2025/09/19 06:33 [pubmed] PHST- 2025/09/19 00:34 [entrez] PHST- 2025/11/17 00:00 [pmc-release] AID - S0007114525105138 [pii] AID - 10.1017/S0007114525105138 [doi] PST - ppublish SO - Br J Nutr. 2025 Sep 28;134(6):518-528. doi: 10.1017/S0007114525105138. Epub 2025 Sep 19. PMID- 40967320 OWN - NLM STAT- MEDLINE DCOM- 20251201 LR - 20260527 IS - 2059-7762 (Electronic) IS - 2059-7754 (Linking) VI - 15 DP - 2025 Dec TI - Thai version of the Marx Activity Rating Scale: Cross-cultural adaptation and validation in patients with anterior cruciate ligament injury. PG - 101000 LID - S2059-7754(25)00617-0 [pii] LID - 10.1016/j.jisako.2025.101000 [doi] AB - INTRODUCTION/OBJECTIVES: The Marx Activity Rating Scale (MARS) is a validated patient-reported outcome measure quantifying high-demand knee activity frequency in anterior cruciate ligament (ACL)-injured populations. The instrument consists of 4 domains: running, cutting, decelerating, and pivoting. This prospective validation study aimed to translate and cross-culturally adapt the MARS into Thai and evaluate its psychometric properties among ACL-injured patients. METHODS: Cross-cultural adaptation followed Beaton's established guidelines, including translation, synthesis, backward translation, expert committee review, and pretesting. Validation of the Thai version of the MARS used dual recall timeframes: MARS with a 1-year recall period (MARS(yr)) and MARS with a 1-month recall period (MARS(mo)). A total of 110 ACL-injured patients, aged 18-50 years with pre-injury Tegner Activity Scale (TAS) scores >/=4, completed questionnaires at the baseline and 2-week follow-up. Psychometric evaluation encompassed construct validity, internal consistency, test-retest reliability, measurement error, and floor/ceiling effects. RESULTS: Cross-cultural adaptation of the Thai version of the MARS was successfully completed. Construct validity of the instrument was demonstrated by correlations between the MARS and the TAS with corresponding timeframes (Spearman's correlation coefficient of 0.51-0.61). Internal consistency was excellent with Cronbach's alpha coefficients of 0.87 (MARS(yr)) and 0.93 (MARS(mo)). Test-retest reliability showed excellent intraclass correlation coefficients of 0.93 (MARS(yr)) and 0.94 (MARS(mo)). Notable floor effects (33.6% for MARS(mo)) and ceiling effects (26.4% for MARS(yr)) were observed. CONCLUSION: The MARS was successfully cross-culturally adapted into the Thai version. It exhibits acceptable psychometric properties for quantifying physical activity in ACL-injured populations. Floor/ceiling effects necessitate complementary outcome measures for comprehensive functional assessment. LEVEL OF EVIDENCE: II. CI - Copyright (c) 2025 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Chawanpaiboon, Pakorn AU - Chawanpaiboon P AD - Division of Sports Medicine, Department of Orthopaedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Golden Jubilee Medical Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Nakhon Pathom, Thailand. FAU - Reosanguanwong, Kongpob AU - Reosanguanwong K AD - Division of Sports Medicine, Department of Orthopaedic Surgery, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand. FAU - Tepa, Wacharapol AU - Tepa W AD - Division of Sports Medicine, Department of Orthopaedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. FAU - Chanchoo, Suchitphon AU - Chanchoo S AD - Division of Sports Medicine, Department of Orthopaedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. FAU - Lertwanich, Pisit AU - Lertwanich P AD - Division of Sports Medicine, Department of Orthopaedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Electronic address: pisit.ler@mahidol.ac.th. LA - eng PT - Journal Article PT - Validation Study DEP - 20250916 PL - England TA - J ISAKOS JT - Journal of ISAKOS : joint disorders & orthopaedic sports medicine JID - 101680867 SB - IM MH - Humans MH - Adult MH - *Anterior Cruciate Ligament Injuries/physiopathology MH - Male MH - Psychometrics MH - Female MH - Reproducibility of Results MH - Thailand MH - Prospective Studies MH - Young Adult MH - *Patient Reported Outcome Measures MH - Middle Aged MH - Adolescent MH - Cross-Cultural Comparison MH - Surveys and Questionnaires MH - Translations MH - Southeast Asian People OTO - NOTNLM OT - Activity rating scale OT - Anterior cruciate ligament OT - Cross-cultural adaptation OT - Marx Activity Rating Scale OT - Measurement properties OT - Patient-reported outcome measure COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/09/19 00:36 MHDA- 2025/12/02 01:00 CRDT- 2025/09/18 19:11 PHST- 2025/06/13 00:00 [received] PHST- 2025/09/02 00:00 [revised] PHST- 2025/09/10 00:00 [accepted] PHST- 2025/12/02 01:00 [medline] PHST- 2025/09/19 00:36 [pubmed] PHST- 2025/09/18 19:11 [entrez] AID - S2059-7754(25)00617-0 [pii] AID - 10.1016/j.jisako.2025.101000 [doi] PST - ppublish SO - J ISAKOS. 2025 Dec;15:101000. doi: 10.1016/j.jisako.2025.101000. Epub 2025 Sep 16. PMID- 40966804 OWN - NLM STAT- MEDLINE DCOM- 20251019 LR - 20251019 IS - 1879-1026 (Electronic) IS - 0048-9697 (Linking) VI - 1001 DP - 2025 Oct 25 TI - The effect of paraben exposure on cognitive and behavioral outcomes in school children. PG - 180434 LID - S0048-9697(25)02074-1 [pii] LID - 10.1016/j.scitotenv.2025.180434 [doi] AB - Parabens are endocrine disruptors (EDCs) whose possible neurotoxicity has not been well explored. This study evaluated the relationship between long-term exposure to parabens, quantified in hair, and cognitive and behavioral performance in schoolchildren in Granada (Spain) using the Wechsler Intelligence Scale for Children-V (WISC-V) and Behavior Assessment System for Children-3 (BASC-3) questionnaires, respectively. A total of 401 children aged 6-12 years (2020-2024) were recruited. Among them, 102 completed the WISC-V and 101 the BASC-3, apart from providing a hair sample to determine six parabens by UHPLC-MS/MS. Associations between exposure to parabens and their effects on neurodevelopment were compared considering high and low exposure (median), in the general population and by sex. Logistic regressions were adjusted for sex, age, BMI and parental educational level. Lower scores on WISC-V indices, specifically on the Fluid Reasoning Index (FRI), Verbal Comprehension Index (VCI), and Full-Scale Intelligence Quotient (FSIQ) were observed among males with the highest exposure to ethylparaben (EthPB). Regarding the behavioral level (BASC-3), the stratification by sex shows a higher likelihood, aggressiveness (OR = 6.08; p = 0.022), conduct problems (OR = 10.10; p = 0.010), behavioral symptom index (OR = 13.76; p = 0.012), and disruptive behavior index (OR = 11.45; p = 0.006) in males exposed to EthPB. In conclusion, our findings suggest that exposure to different parabens may be associated with differences in certain cognitive and behavioral domains assessed by standardized and validated tools (WISC-V and BASC-3). Moreover, sex-stratified analyses modified the relationship between paraben exposure and behavioral domains, reinforcing the presence of sex-specific effects. The design of the study does not allow us to establish causality between exposure to these EDCs and a neurotoxic effect. CI - Copyright (c) 2025 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Gonzalez-Palacios, Patricia AU - Gonzalez-Palacios P AD - Department of Nutrition and Food Science, University of Granada, Granada, Spain; "Jose Mataix Verdu" Institute of Nutrition and Food Technology (INYTA), Biomedical Research Centre (CIBM), University of Granada, Granada, Spain. Electronic address: pgonzapa@ugr.es. FAU - Ramirez, Viviana AU - Ramirez V AD - Department of Nutrition and Food Science, University of Granada, Granada, Spain; "Jose Mataix Verdu" Institute of Nutrition and Food Technology (INYTA), Biomedical Research Centre (CIBM), University of Granada, Granada, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain. Electronic address: vivianarl@ugr.es. FAU - Gonzalez-Domenech, Pablo AU - Gonzalez-Domenech P AD - Department of Psychiatry, Faculty of Medicine, University of Granada, 18016, Granada, Spain. Electronic address: pgdomenech@ugr.es. FAU - Monteagudo, Celia AU - Monteagudo C AD - Department of Nutrition and Food Science, University of Granada, Granada, Spain; "Jose Mataix Verdu" Institute of Nutrition and Food Technology (INYTA), Biomedical Research Centre (CIBM), University of Granada, Granada, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain. Electronic address: celiams@ugr.es. FAU - Baca, Miguel Angel AU - Baca MA AD - MenSana Psychology Center, Granada, Spain. Electronic address: mabaca@cop.es. FAU - Rivas, Ana AU - Rivas A AD - Department of Nutrition and Food Science, University of Granada, Granada, Spain; "Jose Mataix Verdu" Institute of Nutrition and Food Technology (INYTA), Biomedical Research Centre (CIBM), University of Granada, Granada, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain. Electronic address: amrivas@ugr.es. FAU - Zafra-Gomez, Alberto AU - Zafra-Gomez A AD - "Jose Mataix Verdu" Institute of Nutrition and Food Technology (INYTA), Biomedical Research Centre (CIBM), University of Granada, Granada, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain; Department of Analytical Chemistry, University of Granada, Granada, Spain. Electronic address: azafra@ugr.es. LA - eng PT - Journal Article DEP - 20250917 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 RN - 0 (Parabens) RN - 0 (Endocrine Disruptors) RN - 0 (Environmental Pollutants) SB - IM MH - Humans MH - Child MH - Male MH - Female MH - *Parabens/adverse effects MH - *Environmental Exposure/statistics & numerical data MH - *Cognition/drug effects MH - *Endocrine Disruptors/adverse effects MH - Spain MH - *Environmental Pollutants/adverse effects MH - *Child Behavior/drug effects OTO - NOTNLM OT - BASC OT - Behavioral disorders OT - Hair OT - Paraben OT - WISC COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Corresponding authors report financial support was provided by Carlos III Health Institute. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/09/18 18:31 MHDA- 2025/10/20 00:26 CRDT- 2025/09/18 18:01 PHST- 2025/06/16 00:00 [received] PHST- 2025/09/02 00:00 [revised] PHST- 2025/09/04 00:00 [accepted] PHST- 2025/10/20 00:26 [medline] PHST- 2025/09/18 18:31 [pubmed] PHST- 2025/09/18 18:01 [entrez] AID - S0048-9697(25)02074-1 [pii] AID - 10.1016/j.scitotenv.2025.180434 [doi] PST - ppublish SO - Sci Total Environ. 2025 Oct 25;1001:180434. doi: 10.1016/j.scitotenv.2025.180434. Epub 2025 Sep 17. PMID- 40966384 OWN - NLM STAT- MEDLINE DCOM- 20250918 LR - 20260622 IS - 1520-7560 (Electronic) IS - 1520-7552 (Print) IS - 1520-7552 (Linking) VI - 41 IP - 6 DP - 2025 Sep TI - Development of a Chinese-Specific Clinical Model to Predict Maturity-Onset Diabetes of the Young. PG - e70087 LID - 10.1002/dmrr.70087 [doi] LID - e70087 AB - AIMS: Accurate identification of individuals with maturity-onset diabetes of the young (MODY) can support precision diabetes management. However, diagnosing MODY is challenging due to overlapping clinical features with type 2 diabetes. We aimed to develop a prediction model for identifying Chinese with high likelihood of MODY for further genetic testing. METHODS: We developed a logistic regression model using clinical data from an unselected cohort of 1021 Chinese with young-onset (age at diagnosis /= PN need at Day 100 within the allogeneic group. RESULTS: Nutritional intensity varied with different treatment modalities. Chimeric Antigen Receptor T-cell (CAR-T) patients showed notably lower median nutritional intensity score (53.0, 95% CI: 30-117) relative to allogeneic (326.0, 95% CI: 282-404) or stem cell gene therapy (124.5, 95% CI: 56-182, p < 0.05) recipients. Within the allogeneic group (n = 109), patients with malignant diseases had a median nutritional intensity score of 444.0 (95% CI: 350.0-466.0) compared to 261.5 (95% CI: 224.0, 322.0, p < 0.01) in those with nonmalignant conditions. Those receiving total body irradiation (TBI) had higher median nutritional intensity score values (476.0, 95% CI: 317-543) than those without TBI (302.0, 95% CI: 244-386; p < 0.01). In the multivariate analysis, higher nutritional intensity score, malignant disease status, and TBI were significant predictors of >/= PN requirement at Day 100. CONCLUSION: Our nutritional intensity score reflects the cumulative burden of nutritional interventions in paediatric patients, and will inform patient and service planning. Future prospective studies are required to validate its predictive value. CI - (c) 2025 The Author(s). Journal of Human Nutrition and Dietetics published by John Wiley & Sons Ltd on behalf of British Dietetic Association. FAU - Gurumurthy, Gerard AU - Gurumurthy G AUID- ORCID: 0009-0008-0808-8779 AD - The University of Manchester, Manchester, UK. FAU - Dixon, Rebecca AU - Dixon R AD - Royal Manchester Children's Hospital, Manchester, UK. FAU - Whiteley, Victoria AU - Whiteley V AD - Royal Manchester Children's Hospital, Manchester, UK. FAU - Horgan, Claire AU - Horgan C AD - Royal Manchester Children's Hospital, Manchester, UK. FAU - Mustafa, Omima AU - Mustafa O AD - Royal Manchester Children's Hospital, Manchester, UK. FAU - Williams, Nicola AU - Williams N AD - Royal Manchester Children's Hospital, Manchester, UK. FAU - Wynn, Robert AU - Wynn R AD - The University of Manchester, Manchester, UK. LA - eng GR - The authors received no specific funding for this study./ PT - Journal Article PL - England TA - J Hum Nutr Diet JT - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JID - 8904840 SB - IM MH - Humans MH - Retrospective Studies MH - Child MH - Male MH - Female MH - Child, Preschool MH - Infant MH - *Stem Cell Transplantation/adverse effects MH - *Nutritional Support/methods MH - *Genetic Therapy/adverse effects MH - Adolescent MH - Nutritional Status MH - Enteral Nutrition MH - Nutrition Assessment MH - Parenteral Nutrition PMC - PMC12434218 OTO - NOTNLM OT - children OT - chimeric antigen receptor T-cell therapy OT - gene therapy OT - haematopoietic stem cell transplant OT - nutrition assessment OT - parenteral nutrition COIS- The authors declare no conflicts of interest. EDAT- 2025/09/15 06:32 MHDA- 2025/09/16 06:37 PMCR- 2025/09/15 CRDT- 2025/09/15 00:32 PHST- 2025/08/26 00:00 [revised] PHST- 2025/04/29 00:00 [received] PHST- 2025/08/31 00:00 [accepted] PHST- 2025/09/16 06:37 [medline] PHST- 2025/09/15 06:32 [pubmed] PHST- 2025/09/15 00:32 [entrez] PHST- 2025/09/15 00:00 [pmc-release] AID - JHN70124 [pii] AID - 10.1111/jhn.70124 [doi] PST - ppublish SO - J Hum Nutr Diet. 2025 Oct;38(5):e70124. doi: 10.1111/jhn.70124. PMID- 40947075 OWN - NLM STAT- MEDLINE DCOM- 20251217 LR - 20261015 IS - 1873-2607 (Electronic) IS - 0749-3797 (Print) IS - 0749-3797 (Linking) VI - 70 IP - 1 DP - 2026 Jan TI - The Intersection of Tap Water Avoidance, Food Insecurity, and Sugar-Sweetened Beverage Intake Among U.S. Children and Adolescents Aged 2-17 Years. PG - 108104 LID - S0749-3797(25)00572-0 [pii] LID - 10.1016/j.amepre.2025.108104 [doi] AB - INTRODUCTION: This study assessed how the intersection of water insecurity and food insecurity is associated with sugar-sweetened beverage intake among U.S. children and adolescents. METHODS: Data from 18,251 children in the cross-sectional 2005-2006 through 2017-2020 National Health and Nutrition Examination Survey waves were analyzed in 2024-2025. Differences in the consumption of any sugar-sweetened beverage, mean sugar-sweetened beverage kilocalorie, and percent of total kilocalories from sugar-sweetened beverages on a given day across a validated 4-category variable of water insecurity (based on tap water avoidance) and food insecurity (using the U.S. Food Security Survey Module) were assessed with log-binomial and linear regressions. RESULTS: Compared with children with water security and food security, children with water insecurity and food security had a 13% (95% CI=1.06, 1.19; p<0.001) higher prevalence ratio of consuming any sugar-sweetened beverage, consumed 23.3 more kilocalories (SE=6.7; p=0.001), and consumed 1.1% (SE=0.3; p<0.001) more total kilocalories from sugar-sweetened beverages. Children with water security and food insecurity had a 7% (95% CI=1.02, 1.12; p=0.002) higher prevalence ratio of drinking any sugar-sweetened beverage, consumed 13.2 (SE=5.1; p=0.01) more kilocalories, and consumed 0.8% (SE=0.2; p=0.001) more of their total kilocalories from sugar-sweetened beverage. Children experiencing water insecurity and food insecurity had a 15% (95% CI=1.08, 1.22; p<0.001) greater prevalence ratio of sugar-sweetened beverage intake, consumed 36.1 more kilocalories (SE=13.9; p=0.01), and consumed 1.8% (SE=0.4; p<0.001) more of their total kilocalories from sugar-sweetened beverages. CONCLUSIONS: Children experiencing water insecurity or food insecurity alone had higher sugar-sweetened beverage intake than children who had water security and food security, with children experiencing both water insecurity and food insecurity having the highest sugar-sweetened beverage intake. Addressing the intersection of water insecurity and food insecurity may help reduce sugar-sweetened beverage intake. CI - Copyright (c) 2025 Elsevier Inc. All rights reserved. FAU - Rosinger, Asher Y AU - Rosinger AY AD - Department of Biobehavioral Health, The Pennsylvania State University, University Park, Pennsylvania; Department of Anthropology, The Pennsylvania State University, University Park, Pennsylvania; Population Research Institute, The Pennsylvania State University, University Park, Pennsylvania. Electronic address: arosinger@psu.edu. FAU - Young, Sera L AU - Young SL AD - Department of Anthropology, Northwestern University, Evanston, Illinois; Institute for Policy Research, Northwestern University, Evanston, Illinois; Center for Water Research, Northwestern University, Evanston, Illinois. LA - eng GR - P2C HD041025/HD/NICHD NIH HHS/United States GR - R03 HD113976/HD/NICHD NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20250912 PL - Netherlands TA - Am J Prev Med JT - American journal of preventive medicine JID - 8704773 RN - 0 (Drinking Water) SB - IM MH - Humans MH - *Food Insecurity MH - *Sugar-Sweetened Beverages/statistics & numerical data MH - Child MH - Adolescent MH - Male MH - Female MH - Nutrition Surveys MH - Cross-Sectional Studies MH - Child, Preschool MH - United States MH - *Water Insecurity MH - *Food Supply/statistics & numerical data MH - Drinking Water PMC - PMC12500335 MID - NIHMS2111093 COIS- Declaration of interest: The authors declare they have no conflicts of interest. EDAT- 2025/09/15 00:32 MHDA- 2025/12/18 01:31 PMCR- 2026/04/24 CRDT- 2025/09/14 19:16 PHST- 2025/05/14 00:00 [received] PHST- 2025/08/27 00:00 [revised] PHST- 2025/09/04 00:00 [accepted] PHST- 2025/12/18 01:31 [medline] PHST- 2025/09/15 00:32 [pubmed] PHST- 2025/09/14 19:16 [entrez] PHST- 2026/04/24 00:00 [pmc-release] AID - S0749-3797(25)00572-0 [pii] AID - 10.1016/j.amepre.2025.108104 [doi] PST - ppublish SO - Am J Prev Med. 2026 Jan;70(1):108104. doi: 10.1016/j.amepre.2025.108104. Epub 2025 Sep 12. PMID- 40944444 OWN - NLM STAT- MEDLINE DCOM- 20260202 LR - 20260204 IS - 1398-9995 (Electronic) IS - 0105-4538 (Print) IS - 0105-4538 (Linking) VI - 81 IP - 2 DP - 2026 Feb TI - Adherence to Mediterranean Diet During Pregnancy, Breastfeeding, and Development of Food Allergy in the Offspring: Results From the MEDALLION Cohort Study. PG - 563-572 LID - 10.1111/all.70054 [doi] AB - BACKGROUND: Prevention is a key strategy for reducing the burden of food allergies (FA). The maternal diet during pregnancy and breastfeeding is increasingly recognized as a factor contributing to FA risk. METHODS: We analyzed data from a sub-cohort of the MEDALLION study to evaluate the association between maternal adherence to the Mediterranean Diet (MedDiet) and the development of FA in offsprings. Maternal dietary intake during pregnancy and lactation was assessed using a validated scale, i.e., the MedDiet Score, along with individual food group consumption. Multiple logistic regression models were performed. RESULTS: A total of 430 mother-offspring dyads were included in the analysis. Higher maternal adherence to the MedDiet was associated with reduced odds of FA in offspring during both pregnancy (adjusted OR 0.94, 95% CI 0.89-1.00) and lactation (adjusted OR 0.94, 95% CI 0.88-1.00). Increased weekly consumption of fruits and full-fat dairy products during pregnancy, and vegetables during breastfeeding, was associated with reduced likelihood of FA in the offspring. Conversely, higher intake of poultry and red meat (> 3 servings/week) during both periods, and fish consumption during pregnancy (> 1 serving/week), were associated with increased odds of FA. CONCLUSIONS: This study points out that the MedDiet and, especially, some specific components, such as fruits, vegetables, and full-fat dairy products, may contribute to lowering the risk of FA in infants, whereas a higher intake of poultry, red meat, and fish may increase it. These findings support the potential of maternal nutrition to reduce childhood FA. CI - (c) 2025 The Author(s). Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. FAU - Vassilopoulou, Emilia AU - Vassilopoulou E AUID- ORCID: 0000-0002-2665-5908 AD - Department of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, Thessaloniki, Greece. AD - Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, Milan, Italy. AD - Nous Therapy Center, Thessaloniki, Greece. AD - Department of Life Sciences, School of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus. AD - Pediatric Unit, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy. FAU - Karastogiannidou, Calliope AU - Karastogiannidou C AUID- ORCID: 0000-0001-6505-5879 AD - Department of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, Thessaloniki, Greece. FAU - Comotti, Anna AU - Comotti A AUID- ORCID: 0009-0008-4058-8992 AD - Occupational Health Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. FAU - Agostoni, Carlo AU - Agostoni C AUID- ORCID: 0000-0002-5006-0832 AD - Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, Milan, Italy. AD - Pediatric Unit, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy. FAU - Maragkou, Myrto-Kalliopi AU - Maragkou MK AUID- ORCID: 0009-0009-9034-116X AD - Department of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, Thessaloniki, Greece. FAU - Papadopoulos, Nikolaos G AU - Papadopoulos NG AUID- ORCID: 0000-0002-4448-3468 AD - Allergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece. FAU - Pasioti, Maria AU - Pasioti M AUID- ORCID: 0000-0001-6658-4828 AD - Allergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece. FAU - Lithoxopoulou, Maria AU - Lithoxopoulou M AUID- ORCID: 0000-0002-6072-2764 AD - 2nd Department of Neonatology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Feketea, Gavriela AU - Feketea G AUID- ORCID: 0000-0001-9026-2597 AD - Department of Pharmacology, "Luliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. AD - "Karamandaneio" Children's Hospital of Patra, Patra, Greece. FAU - Tsabouri, Sophia AU - Tsabouri S AUID- ORCID: 0000-0001-7584-5401 AD - Department of Pediatrics, School of Medicine, University of Ioannina, Ioannina, Greece. FAU - Milani, Gregorio Paolo AU - Milani GP AUID- ORCID: 0000-0003-3829-4254 AD - Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, Milan, Italy. AD - Pediatric Unit, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy. FAU - Venter, Carina AU - Venter C AUID- ORCID: 0000-0002-7473-5355 AD - Section of Allergy & Immunology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, USA. LA - eng PT - Journal Article DEP - 20250913 PL - Denmark TA - Allergy JT - Allergy JID - 7804028 SB - IM MH - Humans MH - *Diet, Mediterranean MH - Female MH - Pregnancy MH - *Breast Feeding MH - *Food Hypersensitivity/epidemiology/etiology/prevention & control MH - Adult MH - Cohort Studies MH - Male MH - Infant MH - *Prenatal Exposure Delayed Effects MH - Maternal Nutritional Physiological Phenomena MH - Infant, Newborn MH - *Patient Compliance PMC - PMC12862521 OTO - NOTNLM OT - Mediterranean diet OT - allergy prevention OT - dietary patterns OT - food allergy OT - fruit OT - full-fat dairy OT - infant health OT - maternal diet OT - traditional diet OT - vegetables COIS- C.V. has received research funding from Reckitt and has provided consultancy or lectures for Nestle Nutrition Institute, Danone, Reckitt, Abbott, Else Nutrition, Ausnutria, and HAL Allergy. G.P.M. received a grant from Angelini S.P.A. and acted as advisory for scientific projects. Furthermore, he received a grant from Reckitt Benckiser Healthcare S.P.A. All other authors have no conflicts of interest to declare. EDAT- 2025/09/13 06:34 MHDA- 2026/02/02 06:27 PMCR- 2026/02/02 CRDT- 2025/09/13 04:32 PHST- 2025/05/31 00:00 [revised] PHST- 2024/12/05 00:00 [received] PHST- 2025/06/29 00:00 [accepted] PHST- 2026/02/02 06:27 [medline] PHST- 2025/09/13 06:34 [pubmed] PHST- 2025/09/13 04:32 [entrez] PHST- 2026/02/02 00:00 [pmc-release] AID - ALL70054 [pii] AID - 10.1111/all.70054 [doi] PST - ppublish SO - Allergy. 2026 Feb;81(2):563-572. doi: 10.1111/all.70054. Epub 2025 Sep 13. PMID- 40944250 OWN - NLM STAT- MEDLINE DCOM- 20250916 LR - 20250916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 17 DP - 2025 Sep 4 TI - Status of Common Water-Soluble Vitamins in Medical Students: A Cross-Sectional Analysis with Implications for Targeted Nutritional Screening Programs. LID - 10.3390/nu17172862 [doi] LID - 2862 AB - BACKGROUND/OBJECTIVES: Water-soluble vitamins are essential micronutrients requiring regular dietary replenishment due to minimal body storage capacity. Medical students.; despite their health knowledge, may be at risk for subclinical deficiencies due to academic stress and life-style factors. This study assessed water-soluble vitamin status to evaluate screening needs in this educated population. METHODS: A cross-sectional study was conducted among 91 healthy medical students (age 18-23 years) at UAE University from September 2023 to January 2024. Serum levels of folate (B9), cobalamin (B12), and ascorbic acid (Vitamin C) were measured using validated high-performance chemiluminescent immunoassays. Demographic, anthropometric, dietary, and lifestyle data were collected via structured questionnaires. Statistical analyses included multivariate logistic regres-sion, correlation analyses, and receiver operating characteristic (ROC) curves. RESULTS: Among the participants (70.3% female; mean age 19.8 +/- 1.4 years; BMI 23.2 +/- 2.9 kg/m(2)), vita-min C showed the highest prevalence of suboptimal levels at 7.7% (7/91 participants), comprising 2.2% with deficiency (<28 micromol/L, n = 2) and 5.5% with insufficiency (28-40 micromol/L, n = 5). Mean vitamin C was 56.7 +/- 14.8 micromol/L. Vitamin B12 insufficiency (200-300 pg/mL) affected 9.0% (8/89) of students, with a mean of 485.3 +/- 165.0 pg/mL. A non-significant trend toward higher insufficiency rates was observed among female students. No deficiencies were observed for folate (mean 14.1 +/- 4.9 ng/mL). Multivariate analysis identified low fruit/vegetable intake (OR 4.8; 95% CI: 1.3-17.6; p = 0.018); high stress scores (OR 3.2; 95% CI: 1.1-9.4; p = 0.033); and female gender (OR 2.9; 95% CI: 0.9-9.1; p = 0.071) as predictors of suboptimal vitamin C. Vitamin C levels correlated positively with dietary quality (r = 0.412; p < 0.001) and negatively with stress scores (r = -0.241; p = 0.031). Despite being a health-educated population, nearly 10% of medical students demonstrated suboptimal water-soluble vitamin levels, particularly vitamins C and B12. CONCLUSIONS: These findings support implementing targeted screening programs focusing on high-risk groups, including students with poor dietary habits, high stress levels, or specific gender-based risks. FAU - Agha, Adnan AU - Agha A AUID- ORCID: 0000-0002-2704-8931 AD - Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab Emirates. FAU - Yasin, Javed AU - Yasin J AUID- ORCID: 0000-0002-5867-2833 AD - Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab Emirates. FAU - Sharma, Charu AU - Sharma C AUID- ORCID: 0000-0002-1261-7177 AD - Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab Emirates. FAU - Alkaabi, Juma AU - Alkaabi J AUID- ORCID: 0000-0003-2477-0408 AD - Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab Emirates. LA - eng GR - CMHS-NP-25-04 (Faculty Research Grant) with Fund code 12M244 for purchase of consumable and kits only/College of Medicine and health sciences, United Arab Emirates University/ PT - Journal Article DEP - 20250904 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 935E97BOY8 (Folic Acid) RN - P6YC3EG204 (Vitamin B 12) RN - PQ6CK8PD0R (Ascorbic Acid) RN - 0 (Vitamins) SB - IM MH - Humans MH - Female MH - *Students, Medical/statistics & numerical data MH - Cross-Sectional Studies MH - Male MH - Young Adult MH - *Nutritional Status MH - Folic Acid/blood MH - Adolescent MH - Vitamin B 12/blood MH - Ascorbic Acid/blood MH - *Vitamins/blood MH - Saudi Arabia/epidemiology MH - Mass Screening MH - Nutrition Assessment PMC - PMC12430506 OTO - NOTNLM OT - academic stress OT - cross-sectional study OT - medical students OT - micronutrient deficiency OT - nutritional screening OT - vitamin B12 OT - vitamin C OT - water-soluble vitamins OT - young adults COIS- The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2025/09/13 06:34 MHDA- 2025/09/16 18:31 PMCR- 2025/09/04 CRDT- 2025/09/13 01:20 PHST- 2025/08/12 00:00 [received] PHST- 2025/08/30 00:00 [revised] PHST- 2025/09/02 00:00 [accepted] PHST- 2025/09/16 18:31 [medline] PHST- 2025/09/13 06:34 [pubmed] PHST- 2025/09/13 01:20 [entrez] PHST- 2025/09/04 00:00 [pmc-release] AID - nu17172862 [pii] AID - nutrients-17-02862 [pii] AID - 10.3390/nu17172862 [doi] PST - epublish SO - Nutrients. 2025 Sep 4;17(17):2862. doi: 10.3390/nu17172862. PMID- 40944213 OWN - NLM STAT- MEDLINE DCOM- 20250916 LR - 20250916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 17 DP - 2025 Aug 30 TI - Investigating Neophobia Towards New Food Technologies in Italy: The CoNF&TTI Cross-Sectional Study. LID - 10.3390/nu17172825 [doi] LID - 2825 AB - Background/Objectives: Food technology neophobia (FTN), defined as the reluctance to accept or consume foods produced with novel or emerging food technologies, represents a psychological barrier to the adoption of sustainable and innovative dietary practices. This cross-sectional study investigated the prevalence of food technology neophobia and its associated factors among Italian university students. Methods: A total of 1788 undergraduates from 13 universities completed a validated online questionnaire between February and October 2024. The instrument included the Food Technology Neophobia Scale (FTNS), environmental attitude items, and demographic and dietary questions. Results: The mean FTNS score was 51.2 +/- 14.0, suggesting moderate levels of neophobia. Multivariate logistic regression identified several factors inversely associated with neophobia: male gender (OR = 0.73, p = 0.003), paternal university education (OR = 0.73, p = 0.024), studying in Northern Italy (OR = 0.64, p < 0.001), dietary supplement use (OR = 0.74, p = 0.003), and pro-environmental attitudes (OR = 0.97, p < 0.001). Conversely, being a commuter student was associated with increased neophobia (OR = 1.29, p = 0.031). Conclusions: These findings highlight the influence of socio-demographic, behavioral, and attitudinal factors on the acceptance of new food technologies. Tailored strategies are recommended to address FTN in specific subgroups, particularly among female, commuter, and Southern Italian students, to enhance receptivity to food innovation and support sustainable dietary transitions. FAU - Protano, Carmela AU - Protano C AUID- ORCID: 0000-0001-7668-5809 AD - Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy. FAU - Valeriani, Federica AU - Valeriani F AUID- ORCID: 0000-0002-9478-6299 AD - Department of Movement, Human, and Health Sciences, University of Rome "Foro Italico", 00135 Rome, Italy. FAU - Calella, Patrizia AU - Calella P AUID- ORCID: 0000-0003-4649-0589 AD - Department of Medical, Movement and Wellbeing Sciences, University of Naples "Parthenope", 80133 Naples, Italy. FAU - Caggiano, Giuseppina AU - Caggiano G AUID- ORCID: 0000-0003-3009-9147 AD - Interdisciplinary Department of Medicine, University of Bari Aldo Moro, 70124 Bari, Italy. FAU - Bargellini, Annalisa AU - Bargellini A AUID- ORCID: 0000-0002-7562-1472 AD - Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy. FAU - Bianco, Aida AU - Bianco A AUID- ORCID: 0000-0003-4674-0306 AD - Department of Medical and Surgical Sciences, University of Catanzaro "Magna Graecia", 88100 Catanzaro, Italy. FAU - Bianco, Lavinia AU - Bianco L AD - Department of Medical Surgical Sciences and Translational Medicine, Sapienza University of Rome, 00189 Rome, Italy. AD - National Institute for Health, Migration and Poverty (NIHMP), 00153 Rome, Italy. FAU - Borzi, Salvatore AU - Borzi S AD - Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy. FAU - Cataldo, Anastasia AU - Cataldo A AUID- ORCID: 0009-0004-2206-3069 AD - Department of Public Health Sciences and Pediatrics, University of Turin, 10126 Turin, Italy. FAU - Colucci, Maria Eugenia AU - Colucci ME AUID- ORCID: 0000-0003-4971-594X AD - Department of Medicine and Surgery, University of Parma, 43125 Parma, Italy. FAU - Dallolio, Laura AU - Dallolio L AUID- ORCID: 0000-0001-7555-9659 AD - Department of Biomedical and Neuromotor Science, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy. FAU - de Waure, Chiara AU - de Waure C AUID- ORCID: 0000-0002-4346-1494 AD - Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy. FAU - Di Giuseppe, Gabriella AU - Di Giuseppe G AUID- ORCID: 0000-0003-4466-6683 AD - Department of Experimental Medicine, University of Campania "Luigi Vanvitelli" Naples, 80138 Naples, Italy. FAU - Lagana, Pasqualina AU - Lagana P AUID- ORCID: 0000-0002-6078-9520 AD - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98122 Messina, Italy. FAU - La Spada, Giuseppe AU - La Spada G AUID- ORCID: 0000-0002-3227-0131 AD - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98122 Messina, Italy. FAU - Licata, Francesca AU - Licata F AUID- ORCID: 0000-0003-3704-6822 AD - Department of Health Sciences, University of Catanzaro "Magna Graecia", 88100 Catanzaro, Italy. FAU - Marchesi, Isabella AU - Marchesi I AUID- ORCID: 0000-0002-0905-5783 AD - Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy. FAU - Masini, Alice AU - Masini A AUID- ORCID: 0000-0003-1238-3777 AD - Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, 13100 Novara, Italy. FAU - Montagna, Maria Teresa AU - Montagna MT AUID- ORCID: 0000-0002-2958-5458 AD - Interdisciplinary Department of Medicine, University of Bari Aldo Moro, 70124 Bari, Italy. FAU - Napoli, Christian AU - Napoli C AUID- ORCID: 0000-0002-5775-2276 AD - Department of Medical Surgical Sciences and Translational Medicine, Sapienza University of Rome, 00189 Rome, Italy. AD - National Institute for Health, Migration and Poverty (NIHMP), 00153 Rome, Italy. FAU - Oliva, Stefania AU - Oliva S AUID- ORCID: 0009-0009-7274-3552 AD - Department of Medical Surgical Sciences and Translational Medicine, Sapienza University of Rome, 00189 Rome, Italy. AD - National Institute for Health, Migration and Poverty (NIHMP), 00153 Rome, Italy. FAU - Paduano, Giovanna AU - Paduano G AD - Department of Experimental Medicine, University of Campania "Luigi Vanvitelli" Naples, 80138 Naples, Italy. FAU - Paduano, Stefania AU - Paduano S AUID- ORCID: 0000-0003-3640-9177 AD - Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy. FAU - Pasquarella, Cesira AU - Pasquarella C AUID- ORCID: 0000-0003-1566-3854 AD - Department of Medicine and Surgery, University of Parma, 43125 Parma, Italy. FAU - Pelullo, Concetta Paola AU - Pelullo CP AD - Department of Medical, Movement and Wellbeing Sciences, University of Naples "Parthenope", 80133 Naples, Italy. FAU - Persiani, Michela AU - Persiani M AUID- ORCID: 0000-0003-1400-9498 AD - Department of Biomedical and Neuromotor Science, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy. FAU - Romano Spica, Vincenzo AU - Romano Spica V AUID- ORCID: 0000-0002-2900-6399 AD - Department of Movement, Human, and Health Sciences, University of Rome "Foro Italico", 00135 Rome, Italy. FAU - Sacchetti, Rossella AU - Sacchetti R AUID- ORCID: 0000-0002-8762-9973 AD - Department of Education Studies "Giovanni Maria Bertin", Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy. FAU - Scaioli, Giacomo AU - Scaioli G AUID- ORCID: 0000-0001-5189-1294 AD - Department of Public Health Sciences and Pediatrics, University of Turin, 10126 Turin, Italy. FAU - Scicchitano, Concetta Arianna AU - Scicchitano CA AUID- ORCID: 0009-0000-6349-8094 AD - Department of Medical and Surgical Sciences, University of Catanzaro "Magna Graecia", 88100 Catanzaro, Italy. FAU - Siliquini, Roberta AU - Siliquini R AD - Department of Public Health Sciences and Pediatrics, University of Turin, 10126 Turin, Italy. AD - A.O.U. Citta della Salute e della Scienza, 10126 Turin, Italy. FAU - Triggiano, Francesco AU - Triggiano F AD - Interdisciplinary Department of Medicine, University of Bari Aldo Moro, 70124 Bari, Italy. FAU - Veronesi, Licia AU - Veronesi L AD - Department of Medicine and Surgery, University of Parma, 43125 Parma, Italy. FAU - Vitale, Katia AU - Vitale K AD - Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy. FAU - Galle, Francesca AU - Galle F AUID- ORCID: 0000-0002-0504-9562 AD - Department of Medical, Movement and Wellbeing Sciences, University of Naples "Parthenope", 80133 Naples, Italy. LA - eng PT - Journal Article DEP - 20250830 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Italy MH - Female MH - Cross-Sectional Studies MH - Male MH - Young Adult MH - Adult MH - *Students/psychology/statistics & numerical data MH - Surveys and Questionnaires MH - Universities MH - *Food Technology MH - Adolescent MH - Food Preferences/psychology PMC - PMC12430379 OTO - NOTNLM OT - environmental attitude OT - food neophobia OT - food technology OT - food technology neophobia OT - novel food OT - sustainability OT - undergraduates COIS- The authors declare that they have no conflicts of interest relevant to this work. EDAT- 2025/09/13 06:33 MHDA- 2025/09/16 06:38 PMCR- 2025/08/30 CRDT- 2025/09/13 01:20 PHST- 2025/08/14 00:00 [received] PHST- 2025/08/26 00:00 [revised] PHST- 2025/08/27 00:00 [accepted] PHST- 2025/09/16 06:38 [medline] PHST- 2025/09/13 06:33 [pubmed] PHST- 2025/09/13 01:20 [entrez] PHST- 2025/08/30 00:00 [pmc-release] AID - nu17172825 [pii] AID - nutrients-17-02825 [pii] AID - 10.3390/nu17172825 [doi] PST - epublish SO - Nutrients. 2025 Aug 30;17(17):2825. doi: 10.3390/nu17172825. PMID- 40944212 OWN - NLM STAT- MEDLINE DCOM- 20250916 LR - 20250916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 17 DP - 2025 Aug 29 TI - Intuitive Eating Intervention in Physically Active Adults: Effects on Anthropometry, Athletic Performance, Eating Attitudes, and Body Image. LID - 10.3390/nu17172824 [doi] LID - 2824 AB - Background/Objectives: There is growing interest in non-diet approaches to support health, well-being, and performance in different populations. The aim of this study was to evaluate the effects of a 12-week intuitive eating (IE) intervention on participants' body composition, body image, eating behaviors, and athletic performance. Methods: The study included both an intervention group and a control group. It was conducted between September and December 2021. Participants were recruited from a sports center in Istanbul, where they had applied for nutrition and exercise counseling. Inclusion criteria included being 18-65 years old, not having engaged in regular physical activity in the past month, having no chronic disease, and not using any regular medications. Participants were not randomly assigned to groups; allocation was based on availability and willingness to attend the intervention sessions. The study involved 57 participants who were healthy adults between 18 and 65 years old and followed a structured exercise program. At the beginning of the study, a demographic questionnaire was administered. The anthropometric measurements were taken at the beginning and at the end of the intervention. In addition, validated performance and psychometric assessment tools were used, including the Cooper test for cardiovascular endurance, the Davies test for upper-body agility, and the 1-RM bench press for muscular strength, alongside standardized self-report questionnaires for eating attitudes (EAT-26), IE (IES-2), and body image (BCS). Results: The intervention group did not show any statistically significant changes in body composition (p > 0.05). The post-intervention means of the intervention and control groups were not statistically different (p > 0.05). The intervention group showed significant improvements in cardiovascular endurance, agility, and strength performance scores compared to the control group after the intervention (p < 0.05). The intervention group showed significant improvements in body image scores (p < 0.05) and eating attitude scores (p < 0.05). The post-intervention eating attitude and body image scores of the intervention group were significantly different from those of the control group (p < 0.05). The results of the correlation analysis showed a significant positive correlation between intuitive eating and body image (r = 0.455; p < 0.05) and a significant negative correlation between IE and disordered eating attitudes (r = -0.449; p < 0.05). Conclusions: These findings suggest that longer-term interventions may be beneficial and warrant further investigation. IE may serve as a promising strategy to enhance psychological well-being and performance outcomes without focusing on weight control. FAU - Senol, Meltem Piril AU - Senol MP AD - Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. AD - Pirilla Nutrition Consultancy, Istanbul 34365, Turkiye. FAU - Ones, Ece AU - Ones E AUID- ORCID: 0000-0002-9936-8475 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. FAU - Bas, Murat AU - Bas M AUID- ORCID: 0000-0002-0494-301X AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. FAU - Aritici Colak, Gozde AU - Aritici Colak G AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. LA - eng PT - Journal Article DEP - 20250829 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adult MH - *Body Image/psychology MH - Female MH - Male MH - Middle Aged MH - Young Adult MH - *Feeding Behavior/psychology MH - Anthropometry MH - *Athletic Performance/physiology/psychology MH - Body Composition MH - Adolescent MH - *Exercise/physiology MH - Aged PMC - PMC12430477 OTO - NOTNLM OT - athletic performance OT - body composition OT - body image OT - eating attitudes OT - exercise OT - intuitive eating COIS- M.P.S. was employed by Pirilla Nutrition Consultancy. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/09/13 06:32 MHDA- 2025/09/16 06:35 PMCR- 2025/08/29 CRDT- 2025/09/13 01:20 PHST- 2025/08/01 00:00 [received] PHST- 2025/08/21 00:00 [revised] PHST- 2025/08/24 00:00 [accepted] PHST- 2025/09/16 06:35 [medline] PHST- 2025/09/13 06:32 [pubmed] PHST- 2025/09/13 01:20 [entrez] PHST- 2025/08/29 00:00 [pmc-release] AID - nu17172824 [pii] AID - nutrients-17-02824 [pii] AID - 10.3390/nu17172824 [doi] PST - epublish SO - Nutrients. 2025 Aug 29;17(17):2824. doi: 10.3390/nu17172824. PMID- 40944152 OWN - NLM STAT- MEDLINE DCOM- 20250915 LR - 20250916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 17 DP - 2025 Aug 26 TI - Determinants of Diet Quality in Young Football Players from Poznan, Poland. LID - 10.3390/nu17172760 [doi] LID - 2760 AB - BACKGROUND/OBJECTIVES: Proper nutrition is crucial for the growth, development, and performance of young football players. Despite higher nutritional needs, physically active adolescents often have a suboptimal diet. This study assessed the diet quality of youth football players aged 11-16 from Poznan, Poland, focusing on the frequency of consuming health-promoting and non-healthy food groups. METHODS: Participants were Football Championship School students. A total of 78 boys were analyzed and divided into early (11-13 years) and middle adolescence (14-16 years) groups. Dietary behaviours, nutritional knowledge, physical activity, screen time, and family affluence were assessed using a validated questionnaire (SF-FFQ4PolishChildren). The pro-Healthy Diet Index (pHDI) and non-Healthy Diet Index (nHDI) were calculated based on the frequency of food consumption. RESULTS: The key predictors of the pro-Healthy Diet Index (pHDI) were the Cole index (beta = -0.39; p < 0.001), subjective self-assessment of dietary habits (beta = 0.23; p = 0.023), and the level of nutritional knowledge (beta = 0.22; p = 0.030), explaining 25% of the variance in pHDI. In early adolescence, the Cole index was the main predictor (beta = -0.51, p < 0.001, R(2) = 32%), whereas in middle adolescence, self-assessment of dietary habits (beta = 0.49, p = 0.002) and nutritional knowledge (beta = 0.34, p = 0.03, R(2) = 30) were the strongest predictors. Despite high levels of physical activity and positive self-assessment, only 1.28% of participants met all key criteria for a healthy diet. Screen time was negatively correlated with physical activity and positively associated with energy drink consumption. CONCLUSIONS: The results highlight a discrepancy between declared knowledge and actual behaviours, emphasizing the need for targeted, multi-level interventions involving families and coaches to improve dietary practices in young athletes. FAU - Bryl, Ewa AU - Bryl E AUID- ORCID: 0000-0002-4874-459X AD - Department of Human Biological Development, Faculty of Sport Sciences, Poznan University of Physical Education, 61-871 Poznan, Poland. FAU - Demuth, Anna AU - Demuth A AD - Department of Human Biological Development, Faculty of Sport Sciences, Poznan University of Physical Education, 61-871 Poznan, Poland. FAU - Ratajczak, Joanna AU - Ratajczak J AUID- ORCID: 0000-0002-6755-5516 AD - Department of Human Biological Development, Faculty of Sport Sciences, Poznan University of Physical Education, 61-871 Poznan, Poland. FAU - Czerniak, Urszula AU - Czerniak U AUID- ORCID: 0000-0003-4121-0031 AD - Department of Human Biological Development, Faculty of Sport Sciences, Poznan University of Physical Education, 61-871 Poznan, Poland. FAU - Ploszka, Justyna AU - Ploszka J AD - Student Scientific Club at the Department of Swimming and Water Lifesaving, Faculty of Sport Sciences, Poznan University of Physical Education, 61-871 Poznan, Poland. FAU - Lewandowska, Magdalena AU - Lewandowska M AUID- ORCID: 0000-0003-2288-7549 AD - Calculation Centre, Poznan University of Physical Education, 61-871 Poznan, Poland. FAU - Bilska, Agnieszka AU - Bilska A AUID- ORCID: 0000-0002-0908-7347 AD - Department of Food and Nutrition, Faculty of Health Sciences, Poznan University of Physical Education, 61-871 Poznan, Poland. FAU - Antosiak-Cyrak, Katarzyna AU - Antosiak-Cyrak K AD - Department of Swimming and Water Lifesaving, Faculty of Sport Sciences, Poznan University of Physical Education, 61-871 Poznan, Poland. LA - eng PT - Journal Article DEP - 20250826 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Poland MH - Adolescent MH - Child MH - *Diet, Healthy/statistics & numerical data MH - *Soccer MH - *Feeding Behavior MH - *Athletes MH - Exercise MH - *Diet MH - Health Knowledge, Attitudes, Practice MH - Surveys and Questionnaires PMC - PMC12430096 OTO - NOTNLM OT - diet quality OT - dietary habits OT - family influence OT - football players OT - nutrition knowledge OT - nutritional education OT - youth athletes COIS- The authors declare no conflicts of interest. EDAT- 2025/09/13 06:35 MHDA- 2025/09/16 00:34 PMCR- 2025/08/26 CRDT- 2025/09/13 01:20 PHST- 2025/07/05 00:00 [received] PHST- 2025/08/13 00:00 [revised] PHST- 2025/08/25 00:00 [accepted] PHST- 2025/09/16 00:34 [medline] PHST- 2025/09/13 06:35 [pubmed] PHST- 2025/09/13 01:20 [entrez] PHST- 2025/08/26 00:00 [pmc-release] AID - nu17172760 [pii] AID - nutrients-17-02760 [pii] AID - 10.3390/nu17172760 [doi] PST - epublish SO - Nutrients. 2025 Aug 26;17(17):2760. doi: 10.3390/nu17172760. PMID- 40944121 OWN - NLM STAT- MEDLINE DCOM- 20250916 LR - 20250916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 17 DP - 2025 Aug 23 TI - Food Insecurity, Diet and Health Outcomes in Pediatric Inflammatory Bowel Disease: A Pilot Study. LID - 10.3390/nu17172730 [doi] LID - 2730 AB - BACKGROUND/OBJECTIVES: Food insecurity (FI) is a well-defined factor in pediatric health outcomes and has been associated with lower diet quality. While poor diet quality has been linked to the rising prevalence of inflammatory bowel disease (IBD), little is known about the impact of FI on pediatric IBD. This pilot study explores the feasibility and potential impact of FI on dietary intake and clinical outcomes in children with newly diagnosed IBD. METHODS: This pilot study included newly diagnosed IBD patients aged 5 to 18. FI screening was completed using the USDA 6-item and AAP 2-item screeners at diagnosis and 6 months. Dietary intake was classified according to their degree of processing (NOVA classification). Clinical data, anthropometrics, and healthcare utilization were collected over 6 months. RESULTS: Among 20 patients, FI was identified in 40% of families. Food-insecure patients had significantly lower weight and BMI z-scores at diagnosis compared to food-secure peers (p = 0.002 and p = 0.0013, respectively). Food-insecure patients consumed more ultra-processed foods (UPFs, 70.6% vs. 66.7%, p = 0.473). However, most patients consumed diets high in ultra-processed foods. FI status was dynamic over the study period. Hospitalizations were more frequent among food-insecure patients. CONCLUSIONS: FI is common in pediatric IBD and associated with poorer nutritional status. FI was associated with higher consumption of UPFs, although diet quality was poor among most patients. Future studies should validate these findings in large cohorts and evaluate longitudinal interventions. FAU - Zeky, Nicole AU - Zeky N AUID- ORCID: 0000-0002-8724-8660 AD - Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. AD - Division of Pediatric Gastroenterology, Cincinnati, OH 45229, USA. AD - Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA. FAU - Baudier, Alysse AU - Baudier A AD - Manning Family Children's, New Orleans, LA 70118, USA. FAU - Leblanc, Colleen AU - Leblanc C AUID- ORCID: 0000-0002-4554-7195 AD - Manning Family Children's, New Orleans, LA 70118, USA. AD - Division of Pediatric Gastroenterology, Louisiana State University-Health Science Center, New Orleans, LA 70118, USA. FAU - McDonough, Elizabeth AU - McDonough E AD - Manning Family Children's, New Orleans, LA 70118, USA. AD - Division of Pediatric Gastroenterology, Louisiana State University-Health Science Center, New Orleans, LA 70118, USA. FAU - Dumas, Sarah A AU - Dumas SA AD - Department of Pediatrics, Louisiana State University-Health Science Center, New Orleans, LA 70118, USA. FAU - Moulton, Dedrick AU - Moulton D AD - Department of Pediatrics, Louisiana State University-Health Science Center, New Orleans, LA 70118, USA. LA - eng GR - n/a/Louisiana State University Health Sciences Center New Orleans/ PT - Journal Article DEP - 20250823 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Pilot Projects MH - *Inflammatory Bowel Diseases/epidemiology MH - Female MH - Male MH - Child MH - *Food Insecurity MH - Adolescent MH - *Diet MH - Child, Preschool MH - Nutritional Status PMC - PMC12430779 OTO - NOTNLM OT - food insecurity OT - inflammatory bowel disease OT - pediatric COIS- The authors declare no conflicts of interest. EDAT- 2025/09/13 06:35 MHDA- 2025/09/16 13:03 PMCR- 2025/08/23 CRDT- 2025/09/13 01:20 PHST- 2025/07/16 00:00 [received] PHST- 2025/08/11 00:00 [revised] PHST- 2025/08/22 00:00 [accepted] PHST- 2025/09/16 13:03 [medline] PHST- 2025/09/13 06:35 [pubmed] PHST- 2025/09/13 01:20 [entrez] PHST- 2025/08/23 00:00 [pmc-release] AID - nu17172730 [pii] AID - nutrients-17-02730 [pii] AID - 10.3390/nu17172730 [doi] PST - epublish SO - Nutrients. 2025 Aug 23;17(17):2730. doi: 10.3390/nu17172730. PMID- 40941589 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250915 LR - 20250916 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 13 IP - 17 DP - 2025 Sep 8 TI - Determinants of Family Empowerment and Complementary Feeding Quality: Evidence from a Transcultural Care Framework. LID - 10.3390/healthcare13172237 [doi] LID - 2237 AB - Background: Stunting remains a major public health issue globally and in Indonesia, often linked to inadequate complementary feeding, cultural practices, and limited family empowerment. Objective: This study aimed to develop and evaluate a family empowerment model based on transcultural care theory to improve quality and prevent stunting among children aged 6-24 months. Methods: A cross-sectional explanatory survey was conducted among 324 mother-child pairs from 11 primary healthcare centers in Kediri, East Java. Data were collected using a validated questionnaire covering demographic, educational, technological, economic, and cultural factors, as well as family empowerment and quality. Structural Equation Modeling with Partial Least Squares (SEM-PLS) was applied for hypothesis testing and model development. Results: The model showed moderate explanatory power (R(2) = 0.223 for family empowerment; R(2) = 0.115 for complementary feeding quality). Demographic, educational, technological, economic, and cultural factors significantly influenced family empowerment (p < 0.05), which in turn had a strong positive effect on quality (beta = 0.340, p < 0.001). Family empowerment mediated the relationship between these factors and quality. Key contributors included knowledge, technology access, income level, and cultural practices. Conclusions: The proposed transcultural care-based family empowerment model effectively improves quality. Strengthening health education, supporting community health volunteers, and integrating culturally sensitive practices, such as encouraging paternal involvement and shared meals, should be prioritized in stunting prevention programs. The model may be adapted for use in similar community settings to enhance program effectiveness. FAU - Prabowo, Bayu AU - Prabowo B AD - Graduate Programme, Universitas Strada Indonesia, Kediri 64123, Indonesia. FAU - Wardani, Ratna AU - Wardani R AD - Graduate Programme, Universitas Strada Indonesia, Kediri 64123, Indonesia. FAU - Dian, Agusta AU - Dian A AD - Nursing Management, Universitas Strada Indonesia, Kediri 64123, Indonesia. FAU - Suwarto, Suwarto AU - Suwarto S AD - Faculty of Agriculture, Universitas Sebelas Maret, Surakarta 57126, Indonesia. LA - eng PT - Journal Article DEP - 20250908 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12428396 OTO - NOTNLM OT - complementary feeding OT - cultural factors OT - family empowerment OT - maternal education OT - structural equation modeling OT - stunting prevention OT - transcultural nursing COIS- The authors declare no conflicts of interest. EDAT- 2025/09/13 06:34 MHDA- 2025/09/13 06:35 PMCR- 2025/09/08 CRDT- 2025/09/13 01:06 PHST- 2025/07/29 00:00 [received] PHST- 2025/08/28 00:00 [revised] PHST- 2025/09/02 00:00 [accepted] PHST- 2025/09/13 06:35 [medline] PHST- 2025/09/13 06:34 [pubmed] PHST- 2025/09/13 01:06 [entrez] PHST- 2025/09/08 00:00 [pmc-release] AID - healthcare13172237 [pii] AID - healthcare-13-02237 [pii] AID - 10.3390/healthcare13172237 [doi] PST - epublish SO - Healthcare (Basel). 2025 Sep 8;13(17):2237. doi: 10.3390/healthcare13172237. PMID- 40941577 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250915 LR - 20250916 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 13 IP - 17 DP - 2025 Sep 5 TI - The Impact of Nutritional Knowledge of Mothers on Their Children's Nutritional Knowledge and Weight Status. LID - 10.3390/healthcare13172226 [doi] LID - 2226 AB - Objectives: This cross-sectional study assessed the nutritional knowledge of Saudi mothers and their children. Then, it examined the association between the nutritional knowledge of mothers and the nutritional knowledge and weight status of their schoolchildren in Makkah City, Saudi Arabia. Methods: The mothers' nutritional knowledge was assessed using the validated Arabic version of the General Nutrition Knowledge Questionnaire (GNKQ). The children's nutritional knowledge was assessed through an interviewer-administered questionnaire, and their weight status was determined based on their Body Mass Index (BMI) Z-score, which was calculated according to their anthropometric measurements. Results: One hundred children and sixty mothers were included in this study. Only 6.67% of the mothers had a high level of nutrition knowledge. A total of 54% of their children had low nutritional knowledge scores, and approximately 27% was classified as having excess weight. More than 40% of the children reported consuming fruits and vegetables 4-5 times/week, whereas 50% of the children consumed fast foods 1-3 times/week. Multiple linear regression analyses showed that higher nutritional knowledge scores among the children were significantly associated with higher mothers' knowledge scores [(0.06 (95%CI: 0.0.03, 0.0.08)] and older age among these children [0.61 (95%CI: 0.44, 0.77)], as the older children had higher knowledge scores. The children's nutritional knowledge, however, was not associated with the child's sex, mothers' age, or mothers' education. The maternal knowledge scores were not associated with the child's weight status. Conclusions: Given that the nutrition knowledge scores of Saudi mothers are significantly associated with those of their children, but not with their weight status, it can be concluded that nutrition knowledge alone may not be sufficient to address the overweight and obesity epidemic in Saudi Arabia. However, it remains a crucial component of multifaceted interventions that also enhance physical activity and promote behavior change to improve health outcomes and weight status in the Saudi population. FAU - Ghabashi, Mai Adil AU - Ghabashi MA AUID- ORCID: 0009-0003-2917-8400 AD - Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, P.O. Box 715, Makkah 21955, Saudi Arabia. FAU - Babateen, Abrar M AU - Babateen AM AUID- ORCID: 0000-0002-6788-5240 AD - Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, P.O. Box 715, Makkah 21955, Saudi Arabia. FAU - Zagzoog, Alyaa M AU - Zagzoog AM AUID- ORCID: 0000-0001-7707-0371 AD - Department of Community Health, Faculty of Applied Medical Sciences, Northern Border University, P.O. Box 715, Arar 91431, Saudi Arabia. FAU - Aljaadi, Abeer M AU - Aljaadi AM AUID- ORCID: 0000-0003-4646-9210 AD - Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, P.O. Box 715, Makkah 21955, Saudi Arabia. LA - eng PT - Journal Article DEP - 20250905 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12427921 OTO - NOTNLM OT - BMI OT - children, mothers OT - dietary habits OT - fruit and vegetable consumption OT - malnutrition OT - nutrition knowledge OT - obesity COIS- The authors declare no conflicts of interest. EDAT- 2025/09/13 06:34 MHDA- 2025/09/13 06:35 PMCR- 2025/09/05 CRDT- 2025/09/13 01:06 PHST- 2025/06/18 00:00 [received] PHST- 2025/08/09 00:00 [revised] PHST- 2025/08/18 00:00 [accepted] PHST- 2025/09/13 06:35 [medline] PHST- 2025/09/13 06:34 [pubmed] PHST- 2025/09/13 01:06 [entrez] PHST- 2025/09/05 00:00 [pmc-release] AID - healthcare13172226 [pii] AID - healthcare-13-02226 [pii] AID - 10.3390/healthcare13172226 [doi] PST - epublish SO - Healthcare (Basel). 2025 Sep 5;13(17):2226. doi: 10.3390/healthcare13172226. PMID- 40941549 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250915 LR - 20250916 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 13 IP - 17 DP - 2025 Sep 2 TI - Cross-Cultural Adaptation and Validation of the Spanish Version of the Behavioral Regulation in Exercise Questionnaire for Children (BREQ-3C): Analysis of Psychometric Properties. LID - 10.3390/healthcare13172197 [doi] LID - 2197 AB - BACKGROUND/OBJECTIVES: In Spain, a high proportion of children do not meet the recommended daily levels of physical activity (PA), which highlights the urgent need to understand the motivational factors that could influence PA behavior. Self-Determination Theory is a widely used approach for assessing motivation toward exercise, employing instruments such as the Behavioral Regulation in Exercise Questionnaire (BREQ-3). However, despite the cognitive and linguistic differences that limit its direct application, this tool has not yet been adapted for children aged 6-12 years. This study aimed to adapt the BREQ-3 for use with Spanish schoolchildren and to evaluate its validity and reliability in this age group. METHODS: The BREQ-3 for children (BREQ-3C) was linguistically and culturally adapted. Comprehension was tested through cognitive interviews, and reliability was assessed via a test-retest with 125 Spanish schoolchildren. STATISTICAL ANALYSES: Confirmatory factor analysis (CFA), Cronbach's alpha, and the intraclass correlation coefficient (ICC) were used to evaluate validity and reliability. RESULTS: CFA supported the factorial structure of the adapted BREQ-3 for primary schoolchildren, showing acceptable model fit indices (chi-square minimum discrepancy/degrees of freedom (CMIN/df) = 1.552, root mean square error of approximation (RMSEA) = 0.053, comparative fit index (CFI) = 0.891, Tucker-Lewis index (TLI) = 0.870). Internal consistency ranged from poor to excellent for all items and the total score of the questionnaire (Cronbach's alpha (alpha): 0.535 to 0.911), except for items 3, 13, 20, and 21, where the internal consistency was unacceptable. Test-retest reliability was generally satisfactory, with ICC values indicating fair to excellent temporal stability (ICC: 0.248 to 0.911). The measurement error indicators (standard error of measurement percentage (SEM%) and minimal detectable change percentage (MDC%)) varied widely, particularly for the less reliable items. Most item scores were not significantly different between the test and retest groups, although items 2, 3, 5, 9, 17, 19, and 20 were significantly different. CONCLUSIONS: The BREQ-3C has promising psychometric properties for assessing exercise motivation in children aged 6-12 years. This tool shows potential for use in research, education, and health interventions to understand and promote physical activity motivation in primary schools. FAU - Pastor-Cisneros, Raquel AU - Pastor-Cisneros R AUID- ORCID: 0000-0001-7305-6783 AD - Physical Activity for Education, Performance and Health (PAEPH) Research Group, Faculty of Sport Sciences, University of Extremadura, 10003 Caceres, Spain. FAU - Carlos-Vivas, Jorge AU - Carlos-Vivas J AUID- ORCID: 0000-0002-6377-9950 AD - Physical Activity for Education, Performance and Health (PAEPH) Research Group, Faculty of Sport Sciences, University of Extremadura, 10003 Caceres, Spain. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AUID- ORCID: 0000-0002-7412-7624 AD - School of Medicine, Universidad Espiritu Santo, Samborondon 092301, Ecuador. AD - Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno 5290000, Chile. FAU - Mendoza-Munoz, Maria AU - Mendoza-Munoz M AUID- ORCID: 0000-0001-9502-5486 AD - Department of Communication and Education, Universidad Loyola Andalucia, 41014 Sevilla, Spain. LA - eng PT - Journal Article DEP - 20250902 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12427641 OTO - NOTNLM OT - SPLA-C OT - assessment OT - motivation OT - physical activity OT - self-determination theory COIS- The authors declare that they have no conflicts of interest. EDAT- 2025/09/13 06:32 MHDA- 2025/09/13 06:33 PMCR- 2025/09/02 CRDT- 2025/09/13 01:06 PHST- 2025/07/04 00:00 [received] PHST- 2025/08/18 00:00 [revised] PHST- 2025/08/27 00:00 [accepted] PHST- 2025/09/13 06:33 [medline] PHST- 2025/09/13 06:32 [pubmed] PHST- 2025/09/13 01:06 [entrez] PHST- 2025/09/02 00:00 [pmc-release] AID - healthcare13172197 [pii] AID - healthcare-13-02197 [pii] AID - 10.3390/healthcare13172197 [doi] PST - epublish SO - Healthcare (Basel). 2025 Sep 2;13(17):2197. doi: 10.3390/healthcare13172197. PMID- 40941517 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250915 LR - 20250916 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 13 IP - 17 DP - 2025 Aug 30 TI - Health Behaviors and Psychological Well-Being Among First-Year Psychology, Medicine, and Nursing Students: A Cross-Sectional Analysis. LID - 10.3390/healthcare13172162 [doi] LID - 2162 AB - Introduction: Understanding adolescent maturational development and its impact on physical and psychological well-being is essential for supporting the academic and professional growth of undergraduate students in Health Sciences programs (Psychology, Medicine, and Nursing). This study aimed to assess and compare self-concept, self-perception, physical activity, and lifestyle among first-year Health Sciences students. Methods: A descriptive cross-sectional study was conducted with first-year students at the University of La Laguna, Tenerife, Spain. Data were collected using the Rosenberg Self-Esteem Scale (RSES), General Health Questionnaire (GHQ-12), Physical Activity Questionnaire for Adolescents (PAQ-A), and Health Behaviour in School-aged Children (HBSC). Variables included sex, age, study program, and body mass index (BMI). Statistical analyses included descriptive statistics, reliability assessment (Cronbach's alpha), distribution tests, and chi-squared tests. Results: Among 190 participants, the RSES showed generally positive self-esteem, although 75% of students reported low self-confidence. Male Psychology students all scored in the fair range on self-perception. Physical activity was low, particularly among female students, with 20% classified as sedentary. HBSC results indicated the need for lifestyle improvements. SOC-13 scores showed that 80.5% of students had fair levels of sense of coherence. Conclusions: Health Sciences students exhibited low self-concept, emotional distress, sedentary habits, and inadequate lifestyle behaviors. Male Nursing students and female Psychology students had the poorest self-concept scores. The findings emphasize the need for interventions promoting healthy habits and emotional well-being among students entering health-related academic programs. FAU - Palenzuela-Luis, Natacha AU - Palenzuela-Luis N AUID- ORCID: 0009-0002-2358-2130 AD - University Hospital of Canarias, 38320 San Cristobal de La Laguna, Spain. FAU - Duarte-Climents, Gonzalo AU - Duarte-Climents G AUID- ORCID: 0000-0002-8444-7365 AD - Catedra de Enfermeria, University of La Laguna, 38200 San Cristobal de La Laguna, Spain. AD - Cieza Este Health Centre, Murcia Health Service, 30530 Murcia, Spain. AD - Faculty of Health Sciences, International University of Valencia (VIU), 46002 Valencia, Spain. FAU - Gomez-Salgado, Juan AU - Gomez-Salgado J AUID- ORCID: 0000-0001-9053-7730 AD - Department of Sociology, Social Work and Public Health, Faculty of Labour Sciences, University of Huelva, 21007 Huelva, Spain. AD - Safety and Health Postgraduate Program, Universidad Espiritu Santo, Guayaquil 092301, Ecuador. FAU - Rodriguez-Gomez, Jose Angel AU - Rodriguez-Gomez JA AUID- ORCID: 0000-0002-9721-7227 AD - Department of Nursing, University of La Laguna, 38200 San Cristobal de La Laguna, Spain. FAU - Sanchez-Gomez, Maria Begona AU - Sanchez-Gomez MB AUID- ORCID: 0000-0003-3900-292X AD - Catedra de Enfermeria, University of La Laguna, 38200 San Cristobal de La Laguna, Spain. AD - Cieza Este Health Centre, Murcia Health Service, 30530 Murcia, Spain. AD - Research in Health and Social Care Sciences Program, Catholic University of Murcia (UCAM), 30107 Murcia, Spain. LA - eng PT - Journal Article DEP - 20250830 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12427714 OTO - NOTNLM OT - behavior OT - health promotion OT - lifestyle OT - medicine OT - nursing OT - physical activity OT - psychology OT - public health OT - self-concept OT - self-perception OT - students OT - well-being COIS- The authors declare no conflicts of interest. EDAT- 2025/09/13 06:35 MHDA- 2025/09/13 06:36 PMCR- 2025/08/30 CRDT- 2025/09/13 01:06 PHST- 2025/07/12 00:00 [received] PHST- 2025/08/23 00:00 [revised] PHST- 2025/08/26 00:00 [accepted] PHST- 2025/09/13 06:36 [medline] PHST- 2025/09/13 06:35 [pubmed] PHST- 2025/09/13 01:06 [entrez] PHST- 2025/08/30 00:00 [pmc-release] AID - healthcare13172162 [pii] AID - healthcare-13-02162 [pii] AID - 10.3390/healthcare13172162 [doi] PST - epublish SO - Healthcare (Basel). 2025 Aug 30;13(17):2162. doi: 10.3390/healthcare13172162. PMID- 40939275 OWN - NLM STAT- MEDLINE DCOM- 20250928 LR - 20250929 IS - 1532-1983 (Electronic) IS - 0261-5614 (Linking) VI - 53 DP - 2025 Oct TI - Varied effects of sweeteners on pediatric hypertension: A multicenter study. PG - 199-210 LID - S0261-5614(25)00248-1 [pii] LID - 10.1016/j.clnu.2025.08.034 [doi] AB - BACKGROUND & AIMS: The link between sugar-sweetened beverage consumption and metabolic syndrome has prompted the use of non-nutritive sweeteners(NNS). However, emerging evidence links NNS to elevated cardiovascular risk in children. This study examines the association between sweetener consumption and pediatric hypertension to guide cardiovascular health recommendations for children. METHODS: The Taiwan Pubertal Longitudinal Study, initiated in July 2018, is a multicenter, prospective cohort study involving 1696 patients aged 7-17 years. Baseline dietary exposures were collected using the validated NNS Food Frequency Questionnaire covering acesulfame potassium(AceK), aspartame, sucralose, glycyrrhizin, steviol glycosides, sorbitol, and added sugars. Spot urine samples were collected concurrently. Anthropometric and blood pressure measurements were recorded every 3 months. Pediatric hypertension was defined as systolic or diastolic blood pressure at or above 95th percentile for age, sex, and height, using the measurement closest to dietary assessment. Multivariate generalized linear mixed models were used to examine associations between sweetener exposure and pediatric hypertension, adjusting for age, sex, z-BMI, family history of hypertension, total calorie intake, sodium intake, physical activity, parental education, and household income. Participants were recruited on an ongoing basis, and data collected from July 2018 to September 2022 were analyzed. RESULTS: Aspartame and added sugars were dose-dependently associated with increased pediatric hypertension risk (aspartame: OR = 1.69, 95%CI:1.03-2.75; p = 0.04; added sugar: OR = 2.63, 95%CI:1.50-4.60; p < 0.001), while steviol glycosides showed borderline protective effects (p for trend = 0.05). AceK was negatively associated with hypertension in girls (OR = 0.30, 95%CI:0.09-0.98; p = 0.05), whereas aspartame was positively associated with hypertension risk in boys (OR = 3.13, 95%CI:1.30-7.54; p = 0.01). The association between added sugar intake and hypertension was stronger in overweight children. Substituting added sugars with NNS was associated with lower hypertension risk. Urinary biomarker analysis further supported the inverse association between AceK and hypertension, particularly in girls. CONCLUSION: This study demonstrated that aspartame and added sugars were associated with a higher pediatric hypertension risk, while steviol glycosides were linked to lower hypertension risk. Replacing added sugar with NNS was associated with lower pediatric hypertension risk. These findings emphasize the need for tailored dietary guidelines and further investigation on sweetener use in children. CI - Copyright (c) 2025 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. FAU - Tsai, Yuan-Jen AU - Tsai YJ AD - Department of Family Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan. FAU - Fan, Hsien-Yu AU - Fan HY AD - Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan. FAU - Hsu, Shih-Yuan AU - Hsu SY AD - Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. FAU - Lin, Yung-Feng AU - Lin YF AD - Department of Medical Research, Taipei Medical University Hospital, Taipei, Taiwan. FAU - Su, Chien-Tien AU - Su CT AD - Department of Family Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan; School of Public Health, Taipei Medical University, Taipei, Taiwan. FAU - Lin, Huang-Ren AU - Lin HR AD - Department of Family Medicine, Lotung Poh-Ai Hospital, Yilan, Taiwan. Electronic address: c08a001@mail.pohai.org.tw. FAU - Chen, Yang-Ching AU - Chen YC AD - Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan; School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, Taiwan; Nutrition Research Center, Taipei Medical University Hospital, Taipei, Taiwan; TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei 110, Taiwan. Electronic address: melisa26@tmu.edu.tw. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20250904 PL - England TA - Clin Nutr JT - Clinical nutrition (Edinburgh, Scotland) JID - 8309603 RN - 0 (Sweetening Agents) RN - 0 (Non-Nutritive Sweeteners) SB - IM MH - Humans MH - Male MH - Female MH - Child MH - *Hypertension/epidemiology/etiology MH - Adolescent MH - Prospective Studies MH - *Sweetening Agents/adverse effects MH - Longitudinal Studies MH - Taiwan/epidemiology MH - *Non-Nutritive Sweeteners/adverse effects MH - *Diet MH - Blood Pressure MH - Risk Factors OTO - NOTNLM OT - Acesulfame potassium OT - Added sugar OT - Aspartame OT - Nonnutritive sweeteners OT - Pediatric hypertension OT - Steviol glycosides COIS- Conflict of interest The authors declare no conflict of interest to disclose. EDAT- 2025/09/13 00:29 MHDA- 2025/09/29 00:32 CRDT- 2025/09/12 18:03 PHST- 2025/01/22 00:00 [received] PHST- 2025/07/26 00:00 [revised] PHST- 2025/08/29 00:00 [accepted] PHST- 2025/09/29 00:32 [medline] PHST- 2025/09/13 00:29 [pubmed] PHST- 2025/09/12 18:03 [entrez] AID - S0261-5614(25)00248-1 [pii] AID - 10.1016/j.clnu.2025.08.034 [doi] PST - ppublish SO - Clin Nutr. 2025 Oct;53:199-210. doi: 10.1016/j.clnu.2025.08.034. Epub 2025 Sep 4. PMID- 40938854 OWN - NLM STAT- MEDLINE DCOM- 20250916 LR - 20261028 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 9 DP - 2025 TI - Hormonal contraceptives and body composition by use of stable isotope dilution techniques among women of reproductive age in Nyeri County, Kenya. PG - e0332299 LID - 10.1371/journal.pone.0332299 [doi] LID - e0332299 AB - BACKGROUND: Hormonal contraceptives are widely used by women of reproductive age (WRA) globally, yet their impact on body composition remains poorly understood, particularly in low-resource settings. This study aimed to assess the effects of hormonal contraceptives on body composition among WRA in Nyeri County, Kenya, using Stable Isotope Dilution Techniques (SIDT). METHODS: A two-stage cross-sectional analytical study was conducted among 119 women of reproductive age (WRA) aged 18-49 years. However, five participants were excluded from the final analysis. Participants were purposively grouped into hormonal contraceptive users (n = 41), non-hormonal contraceptive users (n = 37), and not on contraceptive (n = 36). After accounting for loss to follow-up, 114 were analysed at baseline and 104 at endline. Contraceptive types included injectables (DMPA), oral pills, and implants (hormonal); and copper IUDs and condoms (non-hormonal). A mid-point (3-month) assessment was conducted for compliance, with the primary body composition outcome measured at six months. Demographic and socioeconomic data were collected using validated structured questionnaires. Body composition was assessed at baseline and six months later using SIDT, with saliva samples analysed to determine total body water (TBW), fat-free mass (FFM), and fat mass (FM). Physical activity (GPAQ) and dietary diversity (WDDS) were measured to control for confounding factors. Logistic regression analysis was adjusted for physical activity, and dietary diversity. RESULTS: Hormonal contraceptive users showed a significant increase in body fat percentage from 35.3 +/- 9.3% to 41.7 +/- 10.6% (p = 0.039) and a reduction in %TBW (47.4 +/- 6.8% to 42.3 +/- 7.8%, p = 0.048). Non-hormonal and non-contraceptive users showed no significant changes. Regression analysis confirmed hormonal contraceptive use was a significant predictor of body fat percentage (Exp(beta) = 0.31, p = 0.026), independent of other factors. CONCLUSION: Hormonal contraceptive use is associated with increased body fat and reduced total body water among WRA in Nyeri County. These changes, independent of physical activity and diet, suggest a direct metabolic effect. Regular body composition monitoring and tailored nutritional guidance are recommended for women using hormonal contraceptives. CI - Copyright: (c) 2025 Lang'at et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Lang'at, Purity Chepkorir AU - Lang'at PC AUID- ORCID: 0000-0001-9719-4902 AD - Department of Food, Nutrition and Dietetics, School of Health Sciences, Kenyatta University, Nairobi, Kenya. AD - Department of Human Nutrition and Dietetics, School of Medicine and Health Sciences, Kabarak University, Nakuru, Kenya. FAU - David-Kigaru, Dorcus Mbithe AU - David-Kigaru DM AD - Department of Food, Nutrition and Dietetics, School of Health Sciences, Kenyatta University, Nairobi, Kenya. FAU - Ndung'u, Zipporah W AU - Ndung'u ZW AD - Department of Human Nutrition Sciences, School of Food and Nutrition Sciences, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya. FAU - Kimeto, Pamela AU - Kimeto P AD - Department of Human Nutrition and Dietetics, School of Medicine and Health Sciences, Kabarak University, Nakuru, Kenya. LA - eng PT - Journal Article DEP - 20250912 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Contraceptive Agents, Hormonal) SB - IM MH - Humans MH - Female MH - Adult MH - Kenya MH - *Body Composition/drug effects MH - Adolescent MH - Young Adult MH - Cross-Sectional Studies MH - Middle Aged MH - *Contraceptive Agents, Hormonal/pharmacology MH - Indicator Dilution Techniques PMC - PMC12431291 COIS- The authors have declared that no competing interests exist. EDAT- 2025/09/12 18:28 MHDA- 2025/09/16 06:37 PMCR- 2025/09/12 CRDT- 2025/09/12 13:33 PHST- 2025/03/27 00:00 [received] PHST- 2025/08/28 00:00 [accepted] PHST- 2025/09/16 06:37 [medline] PHST- 2025/09/12 18:28 [pubmed] PHST- 2025/09/12 13:33 [entrez] PHST- 2025/09/12 00:00 [pmc-release] AID - PONE-D-25-16297 [pii] AID - 10.1371/journal.pone.0332299 [doi] PST - epublish SO - PLoS One. 2025 Sep 12;20(9):e0332299. doi: 10.1371/journal.pone.0332299. eCollection 2025. PMID- 40938420 OWN - NLM STAT- MEDLINE DCOM- 20251124 LR - 20260712 IS - 2153-2176 (Electronic) IS - 2153-2168 (Print) IS - 2153-2168 (Linking) VI - 21 IP - 8 DP - 2025 Dec TI - Parent-Reported Measures of Weight-Related Health Behaviors in Early Childhood: A Scoping Review. PG - 688-712 LID - 10.1177/21532176251369634 [doi] AB - Background: Pediatricians support families in establishing healthy behaviors, yet there is limited information on valid and pragmatic questionnaires for assessing weight-related health behaviors in early childhood (/=30 kg/m(2)). Similarly, PNP was consistently associated with elevated SHyper risk across all stratified populations. Sensitivity analyses confirmed the robustness of these associations, as the relationships between PNP/TCPy and SHyper persisted even after excluding alcohol consumers or iodine-deficient individuals. CONCLUSIONS: Our study suggests that exposure to OPPs is associated with an increased risk of SHyper, an association reflected by the observed correlations between urinary metabolites (PNP and TCPy) and SHyper. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Wei, Gaohui AU - Wei G AD - Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. FAU - Shen, Yi AU - Shen Y AD - Department of Public Health, Youjiang Medical University for Nationalities, Baise, Guangxi, China; Guangxi Key Laboratory on Precise Prevention and Treatment for Thyroid Tumor, The Second Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi, China. FAU - Wang, Xian AU - Wang X AD - Department of Public Health, Youjiang Medical University for Nationalities, Baise, Guangxi, China; Guangxi Key Laboratory on Precise Prevention and Treatment for Thyroid Tumor, The Second Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi, China. FAU - Xiong, Dandan AU - Xiong D AD - Guangxi Key Laboratory on Precise Prevention and Treatment for Thyroid Tumor, The Second Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi, China; School of Science, Guangxi University of Science and Technology, Liuzhou, Guangxi, China. FAU - Zhang, Lingli AU - Zhang L AD - Guangxi Key Laboratory on Precise Prevention and Treatment for Thyroid Tumor, The Second Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi, China; Department of Nuclear Medicine, The Second Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, China. FAU - Zhao, Tianliang AU - Zhao T AD - Department of Public Health, Youjiang Medical University for Nationalities, Baise, Guangxi, China; Guangxi Key Laboratory on Precise Prevention and Treatment for Thyroid Tumor, The Second Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi, China. FAU - Li, Xinjie AU - Li X AD - Department of Public Health, Youjiang Medical University for Nationalities, Baise, Guangxi, China; Guangxi Key Laboratory on Precise Prevention and Treatment for Thyroid Tumor, The Second Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi, China. FAU - Sun, Mengmeng AU - Sun M AD - Guangxi Key Laboratory on Precise Prevention and Treatment for Thyroid Tumor, The Second Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi, China; School of Science, Guangxi University of Science and Technology, Liuzhou, Guangxi, China. FAU - Yu, Sihui AU - Yu S AD - Guangxi Key Laboratory on Precise Prevention and Treatment for Thyroid Tumor, The Second Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi, China; School of Science, Guangxi University of Science and Technology, Liuzhou, Guangxi, China. FAU - Huang, Xueqi AU - Huang X AD - Guangxi Key Laboratory on Precise Prevention and Treatment for Thyroid Tumor, The Second Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi, China; School of Science, Guangxi University of Science and Technology, Liuzhou, Guangxi, China. FAU - Cao, Shengkang AU - Cao S AD - Guangxi Key Laboratory on Precise Prevention and Treatment for Thyroid Tumor, The Second Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi, China; Department of Public Health, School of Medicine, Guangxi University of Science and Technology, Liuzhou, Guangxi, China. FAU - Liao, Ning AU - Liao N AD - Guangxi Key Laboratory on Precise Prevention and Treatment for Thyroid Tumor, The Second Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi, China; Department of Nuclear Medicine, The Second Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, China. Electronic address: ln1212@163.com. FAU - Chen, Tao AU - Chen T AD - Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, China. Electronic address: sychent2009@163.com. FAU - Li, Xiangzhi AU - Li X AD - Department of Public Health, Youjiang Medical University for Nationalities, Baise, Guangxi, China; Guangxi Key Laboratory on Precise Prevention and Treatment for Thyroid Tumor, The Second Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi, China; Department of Public Health, School of Medicine, Guangxi University of Science and Technology, Liuzhou, Guangxi, China. Electronic address: lxz2046@smu.edu.cn. LA - eng PT - Journal Article DEP - 20250909 PL - Netherlands TA - Toxicol Lett JT - Toxicology letters JID - 7709027 RN - 0 (Insecticides) RN - 0 (Organophosphorus Compounds) SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Cross-Sectional Studies MH - Middle Aged MH - Retrospective Studies MH - *Insecticides/urine/adverse effects/toxicity MH - Nutrition Surveys MH - *Hyperthyroidism/urine/chemically induced/epidemiology MH - Young Adult MH - *Environmental Exposure/adverse effects MH - *Organophosphorus Compounds/urine/adverse effects MH - United States/epidemiology MH - Adolescent MH - Risk Factors MH - Aged MH - Risk Assessment OTO - NOTNLM OT - 3,5,6-trichloropyridinol OT - General population OT - NHANES OT - Organophosphate insecticide OT - Paranitrophenol OT - Pesticide OT - Subclinical hyperthyroidism COIS- Declaration of Competing Interest The authors declare no competing interests. EDAT- 2025/09/12 00:29 MHDA- 2025/11/02 00:34 CRDT- 2025/09/11 19:17 PHST- 2025/04/27 00:00 [received] PHST- 2025/09/02 00:00 [revised] PHST- 2025/09/05 00:00 [accepted] PHST- 2025/11/02 00:34 [medline] PHST- 2025/09/12 00:29 [pubmed] PHST- 2025/09/11 19:17 [entrez] AID - S0378-4274(25)02663-3 [pii] AID - 10.1016/j.toxlet.2025.111723 [doi] PST - ppublish SO - Toxicol Lett. 2025 Nov;413:111723. doi: 10.1016/j.toxlet.2025.111723. Epub 2025 Sep 9. PMID- 40934610 OWN - NLM STAT- MEDLINE DCOM- 20251017 LR - 20260915 IS - 1872-8243 (Electronic) IS - 1386-5056 (Linking) VI - 205 DP - 2026 Jan TI - Revolutionizing pediatric obesity intervention strategies: From traditional growth reference tools to AI-enabled pediatric obesity clinical decision support systems. PG - 106109 LID - S1386-5056(25)00326-0 [pii] LID - 10.1016/j.ijmedinf.2025.106109 [doi] AB - BACKGROUND: Childhood obesity is a growing public health concern that can seriously impact children's physical development and long-term health if left unaddressed. Effective monitoring and early intervention are crucial for managing this risk. OBJECTIVE: This study aims to evaluate the performance and clinical relevance of the Pediatric Obesity and Weight Management (PedOWM) tool, a semantic rule-based Clinical Decision Support System (CDSS) designed to assess and manage childhood and adolescent obesity using national anthropometric data. METHOD: PedOWM was tested using retrospective auxological data from 100 Turkish children, predominantly composed of overweight and obese individuals, but also including cases from other BMI categories such as underweight and normal weight. The system analyzed anthropometric measurements and generated treatment recommendations based on its semantic rules. Its results(e.g., BMI, Z-scores, percentiles) were compared with three widely used pediatric growth reference tools: CEDD-Cozum (Turkey), BCM (Baylor College of Medicine, USA), and CDC (Centers for Disease Control and Prevention, USA). The evaluation included visual plot comparisons, expert assessments by a pediatric endocrinologist, statistical analyses, and a performance comparison between PedOWM's recommendations and those of the clinical expert. RESULTS: PedOWM's results were largely consistent with those produced by the three tools, particularly CEDD-Cozum, supporting its reliability and validity in clinical evaluations. Statistically significant discrepancies observed with CDC and BCM were primarily attributed to differences in reference populations and the absence of data for children under two years of age. Furthermore, PedOWM's treatment recommendations showed strong concordance with expert clinical decisions, achieving performance metrics of 99.5 % accuracy, 97.1 % precision, 97.5 % recall, and 97.6 % F1-score. CONCLUSION: Increasing societal awareness of the risks associated with childhood obesity can drive proactive measures, leading to timely interventions that significantly enhance health outcomes for children. The results obtained demonstrate promising findings regarding the applicability, effectiveness, and efficiency of PedOWM, which facilitates collaboration among healthcare professionals, parents, patients, and dietitians. CI - Copyright (c) 2025. Published by Elsevier B.V. FAU - Ertugrul, Duygu Celik AU - Ertugrul DC AD - Department of Computer Engineering, Engineering Faculty, Eastern Mediterranean University, 99628 Famagusta, North Cyprus, via Mersin-10, Turkey. Electronic address: duygu.celik@emu.edu.tr. FAU - Akcan, Nese AU - Akcan N AD - Department of Pediatric Endocrinology, Faculty of Medicine, Near East University, 99138 Nicosia, North Cyprus, via Mersin-10, Turkey. FAU - Bitirim, Yiltan AU - Bitirim Y AD - Department of Computer Engineering, Engineering Faculty, Eastern Mediterranean University, 99628 Famagusta, North Cyprus, via Mersin-10, Turkey. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250903 PL - Ireland TA - Int J Med Inform JT - International journal of medical informatics JID - 9711057 SB - IM MH - Humans MH - *Pediatric Obesity/therapy/diagnosis MH - *Decision Support Systems, Clinical MH - Child MH - Adolescent MH - Female MH - Male MH - *Artificial Intelligence MH - Retrospective Studies MH - Child, Preschool MH - Body Mass Index MH - Turkey OTO - NOTNLM OT - Childhood obesity management OT - Clinical decision support systems OT - Health Informatics OT - Obesity OT - Pediatric growth reference measurement tools COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/09/12 00:29 MHDA- 2025/10/18 00:30 CRDT- 2025/09/11 18:02 PHST- 2025/02/18 00:00 [received] PHST- 2025/07/24 00:00 [revised] PHST- 2025/09/01 00:00 [accepted] PHST- 2025/10/18 00:30 [medline] PHST- 2025/09/12 00:29 [pubmed] PHST- 2025/09/11 18:02 [entrez] AID - S1386-5056(25)00326-0 [pii] AID - 10.1016/j.ijmedinf.2025.106109 [doi] PST - ppublish SO - Int J Med Inform. 2026 Jan;205:106109. doi: 10.1016/j.ijmedinf.2025.106109. Epub 2025 Sep 3. PMID- 40934534 OWN - NLM STAT- MEDLINE DCOM- 20251202 LR - 20261002 IS - 1746-1561 (Electronic) IS - 0022-4391 (Print) IS - 0022-4391 (Linking) VI - 96 IP - 1 DP - 2026 Jan TI - A New Program for Determining Abnormal Growth Curves in School Health Checkups. PG - e70088 LID - 10.1111/josh.70088 [doi] LID - e70088 AB - BACKGROUND: In Japan, school health examinations frequently utilize growth curves. This study aimed to develop and validate a custom-designed program that enables the rapid and accurate detection of growth abnormalities in children and adolescents. METHODS: We created a novel screening tool named the Growth Assessment Program for Schools (GAPS), implemented using Visual Basic for Applications (VBA) in Microsoft Excel. Using the 2021 school health checkup data (IZUMO 2021; 12,573 students, aged 6-15 years) from Izumo City, we validated the program's accuracy against both the frequently used abnormal growth curve determination program (V4) and an expert review committee. RESULTS: The GAPS tool enables one-click generation of individualized growth curves and automated identification of abnormal patterns. It successfully detected growth disorders, including cases such as precocious puberty, that were initially overlooked by tV4 (341 cases, 2.9%). Compared to V4, the GAPS tool demonstrated improved sensitivity (0.99) and positive predictive value (0.16), though with a higher false positive rate (0.24). IMPLICATIONS FOR SCHOOL HEALTH POLICY, PRACTICE, AND EQUITY: GAPS allows for immediate application by school personnel, including non-specialist school physicians, enabling real-time health surveillance and improving the quality of school-based pediatric care. CONCLUSION: We developed and validated GAPS, a user-friendly and highly efficient tool for detecting abnormal growth curves in school health settings in Japan. It offers advantages in speed, accuracy, and usability over existing programs. This program also holds potential use in broader populations, provided population-specific growth data are available. CI - (c) 2025 The Author(s). Journal of School Health published by Wiley Periodicals LLC on behalf of American School Health Association. FAU - Wada, Keisuke AU - Wada K AD - Department of Pediatrics, Shimane University Faculty of Medicine, Izumo, Shimane, Japan. FAU - Kawashima-Sonoyama, Yuki AU - Kawashima-Sonoyama Y AUID- ORCID: 0000-0002-2338-8293 AD - Department of Pediatrics, Shimane University Faculty of Medicine, Izumo, Shimane, Japan. FAU - Abe, Hiroto AU - Abe H AD - Department of Control Engineering, National Institute of Technology, Matsue, Shimane, Japan. AD - College of Information Science, Tsukuba, Japan. FAU - Toya, Akihiro AU - Toya A AD - Department of Control Engineering, National Institute of Technology, Matsue, Shimane, Japan. FAU - Kobayashi, Hironori AU - Kobayashi H AD - Department of Clinical Laboratory, Shimane University Hospital, Izumo, Shimane, Japan. FAU - Taketani, Takeshi AU - Taketani T AUID- ORCID: 0000-0002-3257-1305 AD - Department of Pediatrics, Shimane University Faculty of Medicine, Izumo, Shimane, Japan. LA - eng GR - FY2021/"Shimane University Grants for Joint Research Project led by Female Researchers" under the MEXT Initiative for Realizing Diversity in the Research Environment (Collaboration Type)/ GR - Kakenhi 24K14601/Japan Society for the Promotion of Science/ GR - FY 2025 Open Theme Research Grant from the Foundation for Growth Science, Japan/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250911 PL - United States TA - J Sch Health JT - The Journal of school health JID - 0376370 SB - IM MH - Humans MH - Child MH - Adolescent MH - *School Health Services/organization & administration MH - Japan MH - Male MH - Female MH - *Growth Charts MH - *Growth Disorders/diagnosis MH - *Mass Screening/methods PMC - PMC12669807 OTO - NOTNLM OT - VBA OT - growth curve OT - precocious puberty OT - school health checkup COIS- The authors declare no conflicts of interest. EDAT- 2025/09/11 18:29 MHDA- 2025/12/02 07:36 PMCR- 2025/12/02 CRDT- 2025/09/11 17:52 PHST- 2025/07/06 00:00 [revised] PHST- 2025/04/24 00:00 [received] PHST- 2025/08/27 00:00 [accepted] PHST- 2025/12/02 07:36 [medline] PHST- 2025/09/11 18:29 [pubmed] PHST- 2025/09/11 17:52 [entrez] PHST- 2025/12/02 00:00 [pmc-release] AID - JOSH70088 [pii] AID - 10.1111/josh.70088 [doi] PST - ppublish SO - J Sch Health. 2026 Jan;96(1):e70088. doi: 10.1111/josh.70088. Epub 2025 Sep 11. PMID- 40934233 OWN - NLM STAT- MEDLINE DCOM- 20250915 LR - 20260930 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 9 DP - 2025 TI - Behavioural risk factors for cardiovascular diseases among adolescents of secondary school in Tulsipur Sub-Metropolitan City, Nepal: A cross-sectional study. PG - e0313943 LID - 10.1371/journal.pone.0313943 [doi] LID - e0313943 AB - BACKGROUND: Cardiovascular diseases (CVDs) are a leading cause of global death and disability, affecting one-third of adult population. Often overlooked in school-going adolescents, behavioural risk factors are crucial contributors to CVD risk which begin early and accelerate during adolescent period. This study aims to assess the behavioural risk factors and their associated determinants among adolescents of Tulsipur Sub-Metropolitan City, Nepal. METHODS: A school-based cross-sectional study was conducted among 361 adolescents aged 16-19 years studying in grade 11 and 12 from public and private schools. Schools were selected using a stratified proportionate sampling method. Data were collected through a self-administered, structured, and validated questionnaire covering socio-demographic characteristics, behavioural risk factors of CVDs, and parental information. Descriptive and analytical statistics were used to analyse the data. RESULTS: The most prevalent behavioural risk factor was the consumption of calorie drinks (99%), followed by sedentary behaviour (60%), insufficient fruit and vegetable intake (57%), physical inactivity (35%), and consumption of processed food high in salt (33%). The prevalence of current smoking, alcohol consumption, and smokeless tobacco use was 12%, 10%, and 9% respectively. Key factors associated with the behavioural risk include maternal education, ethnicity, and education system. Parental tobacco and alcohol use were also associated with adolescent smoking and alcohol consumption. CONCLUSIONS: The high prevalence of CVD risk factors among adolescents in Nepal highlights the urgent need for targeted interventions in both household and school settings. These interventions should aim to reduce behavioural risk factors to prevent the future burden of CVDs in resource-limited areas like Nepal. CI - Copyright: (c) 2025 Bista et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Bista, Sita AU - Bista S AUID- ORCID: 0009-0007-5805-7607 AD - Central Department of Public Health, Tribhuvan University Institute of Medicine, Kathmandu, Nepal. FAU - Puri, Bishow AU - Puri B AD - Central Department of Public Health, Tribhuvan University Institute of Medicine, Kathmandu, Nepal. FAU - Maharjan, Sanju AU - Maharjan S AUID- ORCID: 0009-0009-3454-574X AD - Central Department of Public Health, Tribhuvan University Institute of Medicine, Kathmandu, Nepal. FAU - Thapa, Poshan AU - Thapa P AD - School of Population and Global Health, McGill University, Quebec, Canada. FAU - Bhandari, Buna AU - Bhandari B AD - Florida State University College of Nursing, Tallahassee, Florida, United States of America. AD - Department of Global and Population Health, Harvard Chan School of Public Health, United States of America. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250911 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Adolescent MH - Nepal/epidemiology MH - Male MH - Female MH - Cross-Sectional Studies MH - *Cardiovascular Diseases/epidemiology/etiology MH - Schools MH - Risk Factors MH - Young Adult MH - Sedentary Behavior MH - Alcohol Drinking/epidemiology MH - Smoking/epidemiology MH - Surveys and Questionnaires PMC - PMC12425188 COIS- The authors have declared that no competing interests exist. EDAT- 2025/09/11 18:29 MHDA- 2025/09/16 00:32 PMCR- 2025/09/11 CRDT- 2025/09/11 13:43 PHST- 2024/11/02 00:00 [received] PHST- 2025/08/15 00:00 [accepted] PHST- 2025/09/16 00:32 [medline] PHST- 2025/09/11 18:29 [pubmed] PHST- 2025/09/11 13:43 [entrez] PHST- 2025/09/11 00:00 [pmc-release] AID - PONE-D-24-49797 [pii] AID - 10.1371/journal.pone.0313943 [doi] PST - epublish SO - PLoS One. 2025 Sep 11;20(9):e0313943. doi: 10.1371/journal.pone.0313943. eCollection 2025. PMID- 40934148 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260813 IS - 1938-8993 (Electronic) IS - 1540-4153 (Print) IS - 1540-4153 (Linking) VI - 24 IP - 3 DP - 2026 Sep TI - The Translation and Cultural Adaptation of the Pediatric Eating Assessment Tool in Puerto Rican Spanish: A Comparison between Dyads in Puerto Rico and Mainland United States during the COVID-19 Pandemic. PG - 123-132 LID - 10.1177/15404153251365932 [doi] AB - Currently there are no validated pediatric feeding assessment tools available in Puerto Rican (PR) Spanish. This study aimed to (1) translate and culturally adapt the Pediatric Eating Assessment Tool (PediEAT) for use with PR Spanish speakers, (2) test the internal consistency of the adapted version, and (3) administer the translated and adapted PediEAT to a PR cohort and compare those results with age-matched toddlers in the mainland United States (US). We hypothesized that we would be able to effectively translate PediEAT into PR Spanish with high internal consistency and that infants in the PR cohort would have more parent-reported problematic feeding behaviors compared to the mainland US sample. The translated and culturally adapted PR Spanish PediEAT version was administered to 15 caregiver-toddler dyads in PR and the test demonstrated high internal consistency (alpha = 0.869). The mainland US cohort reported significantly higher PediEAT ratings of feeding difficulty than the PR cohort in the Selective/Restrictive Eating subscale (p = 0.031). This outcome may be attributed to cultural factors that are different in the PR community compared to the mainland. Future research is needed to explore these differences in more detail with a larger sample size. FAU - Westemeyer, Ross M AU - Westemeyer RM AUID- ORCID: 0000-0001-5803-8173 AD - Department of Communication Sciences & Disorders, Northeastern University, Boston, MA, USA. RINGGOLD: 195088 FAU - Iizuka, Alicia AU - Iizuka A AD - Department of Communication Sciences & Disorders, Northeastern University, Boston, MA, USA. RINGGOLD: 195088 FAU - Huerta-Montanez, Gredia AU - Huerta-Montanez G AD - Department of Communication Sciences & Disorders, Northeastern University, Boston, MA, USA. RINGGOLD: 195088 FAU - Rosaria Pabon, Zaira Y AU - Rosaria Pabon ZY AD - Department of Communication Sciences & Disorders, Northeastern University, Boston, MA, USA. RINGGOLD: 195088 FAU - Pados, Britt F AU - Pados BF AUID- ORCID: 0000-0002-8016-2370 AD - Infant Feeding Care, Wellesley Hills, MA, USA. FAU - Hines, Morgan AU - Hines M AD - Department of Communication Sciences & Disorders, Northeastern University, Boston, MA, USA. RINGGOLD: 195088 FAU - Martens, Alaina AU - Martens A AUID- ORCID: 0000-0001-5335-1873 AD - Department of Communication Sciences & Disorders, Northeastern University, Boston, MA, USA. RINGGOLD: 195088 FAU - Phillips, Hannah AU - Phillips H AD - Department of Communication Sciences & Disorders, Northeastern University, Boston, MA, USA. RINGGOLD: 195088 FAU - Zimmerman, Emily AU - Zimmerman E AUID- ORCID: 0000-0002-1096-3623 AD - Department of Communication Sciences & Disorders, Northeastern University, Boston, MA, USA. RINGGOLD: 195088 LA - eng GR - R21 HD095321/HD/NICHD NIH HHS/United States PT - Comparative Study PT - Journal Article DEP - 20250911 PL - United States TA - Hisp Health Care Int JT - Hispanic health care international : the official journal of the National Association of Hispanic Nurses JID - 101150304 SB - IM MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - COVID-19 MH - Cross-Cultural Comparison MH - *Feeding Behavior/ethnology MH - *Hispanic or Latino/ethnology MH - Pandemics MH - Puerto Rico/epidemiology/ethnology MH - Reproducibility of Results MH - *Surveys and Questionnaires/standards MH - Translations MH - United States/epidemiology MH - Language MH - *Nutrition Surveys/standards PMC - PMC12798888 MID - NIHMS2135368 OTO - NOTNLM OT - children's health OT - cultural adaptations OT - evaluation research OT - pediatrics COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/09/11 18:30 MHDA- 2026/08/06 12:37 PMCR- 2026/08/06 CRDT- 2025/09/11 13:23 PHST- 2026/08/06 12:37 [medline] PHST- 2025/09/11 18:30 [pubmed] PHST- 2025/09/11 13:23 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 10.1177_15404153251365932 [pii] AID - 10.1177/15404153251365932 [doi] PST - ppublish SO - Hisp Health Care Int. 2026 Sep;24(3):123-132. doi: 10.1177/15404153251365932. Epub 2025 Sep 11. PMID- 40933422 OWN - NLM STAT- MEDLINE DCOM- 20250915 LR - 20250915 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Development and cross-validation of LMS-based normative reference standards and health benefits zones for muscular strength among adolescents by age and sex. PG - 1616298 LID - 10.3389/fpubh.2025.1616298 [doi] LID - 1616298 AB - OBJECTIVE: This study aims to develop and validate age- and sex-specific normative reference standards for muscular strength (MS) using the LMS (Lambda-Mu-Sigma) method and to establish Health Benefit Zones (HBZs) for Pakistani adolescents aged 12-16 years. METHODS: A cross-sectional study was conducted with 2,970 adolescents (49.7% boys, 50.3% girls) selected through stratified random sampling from 60 public high schools across three divisions of South Punjab. Anthropometric indicators and muscular strength were measured following standardized protocols. Using the LMS, age- and sex-specific normative reference values and smoothed percentile curves (3rd, 10th, 35th, 50th, 65th, and 90th) were developed. Five Health Benefit Zones (Very Poor, Poor, Medium, Good, and Excellent) were derived from these percentile ranges to classify strength levels. The robustness of the generated standards was examined through internal cross-validation using a back-generation procedure to confirm high predictive accuracy. RESULTS: Boys demonstrated significantly higher muscular strength than girls across all ages (p < 0.001), with strength increasing progressively with age in both sexes. At age 16, median MS reached 35.47 kg for boys and 20.18 kg for girls. LMS-derived percentile reference values and percentile curves illustrated consistent age- and sex-related growth trends. Approximately 40% of participants fell within the "poor" or "very poor" HBZs. MAPE values remained below +/-0.05, indicating excellent model fit. Compared to international benchmarks, adolescents from South Punjab exhibited lower MS values across corresponding age groups. CONCLUSION: This study provides the first LMS-based, age- and sex-specific normative reference standards and HBZs for muscular strength among Pakistani adolescents. These standards offer a population-relevant tool for fitness assessment, enable early identification of youth at risk of low muscular strength, and support targeted interventions to enhance strength development and overall physical health in school-aged populations. CI - Copyright (c) 2025 Yang, Hadier, Long, Hamdani and Hamdani. FAU - Yang, Yang AU - Yang Y AD - School of Physical Education, Suzhou University, Suzhou, Anhui, China. FAU - Hadier, Syed Ghufran AU - Hadier SG AD - Department of Sports Sciences, Bahauddin Zakariya University, Multan, Pakistan. AD - School of Physical Education, Shanxi University, Taiyuan, China. FAU - Long, Liu AU - Long L AD - School of Physical Education, Suzhou University, Suzhou, Anhui, China. FAU - Hamdani, Syed Muhammad Zeeshan Haider AU - Hamdani SMZH AD - Department of Sports Sciences, Bahauddin Zakariya University, Multan, Pakistan. AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Hamdani, Syed Danish AU - Hamdani SD AD - Division of Olympic Sports, China Swimming College, Beijing Sport University, Beijing, China. LA - eng PT - Journal Article DEP - 20250826 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Adolescent MH - Male MH - *Muscle Strength/physiology MH - Female MH - Cross-Sectional Studies MH - Reference Values MH - Child MH - Pakistan MH - Reference Standards MH - Sex Factors MH - Age Factors MH - Anthropometry PMC - PMC12418043 OTO - NOTNLM OT - LMS method OT - adolescent fitness OT - back-generation method OT - cross-validation OT - handgrip strength OT - health benefit zones OT - muscular strength OT - normative reference standards COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/09/11 18:29 MHDA- 2025/09/15 18:33 PMCR- 2025/08/26 CRDT- 2025/09/11 12:36 PHST- 2025/04/22 00:00 [received] PHST- 2025/08/06 00:00 [accepted] PHST- 2025/09/15 18:33 [medline] PHST- 2025/09/11 18:29 [pubmed] PHST- 2025/09/11 12:36 [entrez] PHST- 2025/08/26 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1616298 [doi] PST - epublish SO - Front Public Health. 2025 Aug 26;13:1616298. doi: 10.3389/fpubh.2025.1616298. eCollection 2025. PMID- 40933336 OWN - NLM STAT- MEDLINE DCOM- 20250915 LR - 20250915 IS - 1303-2968 (Electronic) IS - 1303-2968 (Linking) VI - 24 IP - 3 DP - 2025 Sep TI - Quantifying Running Economy in Amateur Runners: Evaluating VO(2) and Energy Cost with Model-based Normalization. PG - 684-695 LID - 10.52082/jssm.2025.684 [doi] AB - Submaximal oxygen uptake (VO(2sub)) scaled by ratio is commonly used to evaluate running economy (RE) to reflect metabolic consumption at a given submaximal-intensity velocity. However, this method is questionable due to its neglect of substrate-related issues and the inherent mathematical discrepancies in ratio scaling. This study aimed to investigate the validity of ratio-scaled VO(2sub) as a measure of RE by comparing it with allometric-scaled energy cost (E(c), kcal/kg(b)/min). Sixty-nine recreationally active college students underwent VO(2max) tests and discontinuous submaximal running assessments at three %VO(2max) intensities. A 1000-meter test assessed running performance. One-way repeated-measures ANOVA compared changes in VO(2sub) or E(c) with increasing running intensities. Regression analysis explored methods for metabolic data standardization. Pearson correlation coefficient evaluated the effectiveness of standardization and the correlations between sports performance and RE scaled by different measures. Magnitude-based inferences were used to assess sex differences and probabilities of RE at each running intensity. Both VO(2sub) and E(c) significantly increased with increasing intensities, suggesting that VO(2sub) is a valid quantification of RE. Allometric scaling is more suitable than ratio scaling for removing the influence of body weight on both E(c) and VO(2sub), with females showing better RE. Allometric-scaled E(c) was sensitive in detecting correlations with performance, strongest at 65% VO(2max). While VO(2sub) is a valid quantification of RE, allometric scaling, rather than ratio scaling, should be used to normalize the RE quantification before performing reliable interindividual comparisons. The 2/3 law can be considered as the exponent b value for body weight. Additionally, 65%VO(2max) intensity is recommended as the submaximal testing intensity in the RE test. Nonetheless, more studies with diverse samples are needed to confirm the validity. CI - (c) Journal of Sports Science and Medicine. FAU - Lee, Jay AU - Lee J AD - Faculty of Education, University of Macau, Macao, China. AD - School of Physical Education & Sports Science, South China Normal University, Guangzhou, China. FAU - Zhang, Xiuli AU - Zhang X AD - School of Physical Education & Sports Science, South China Normal University, Guangzhou, China. FAU - Kong, Zhaowei AU - Kong Z AD - Faculty of Education, University of Macau, Macao, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20250901 PL - Turkey TA - J Sports Sci Med JT - Journal of sports science & medicine JID - 101174629 SB - IM MH - Humans MH - *Running/physiology MH - *Oxygen Consumption/physiology MH - Female MH - Male MH - *Energy Metabolism/physiology MH - Young Adult MH - Adult MH - Exercise Test MH - Sex Factors MH - *Athletic Performance/physiology MH - Regression Analysis MH - Adolescent PMC - PMC12418179 OTO - NOTNLM OT - Running economy OT - allometric scaling OT - energy cost OT - oxygen consumption OT - ratio scaling EDAT- 2025/09/11 18:30 MHDA- 2025/09/15 18:35 PMCR- 2025/09/01 CRDT- 2025/09/11 12:34 PHST- 2025/06/06 00:00 [received] PHST- 2025/08/01 00:00 [accepted] PHST- 2025/09/15 18:35 [medline] PHST- 2025/09/11 18:30 [pubmed] PHST- 2025/09/11 12:34 [entrez] PHST- 2025/09/01 00:00 [pmc-release] AID - 10.52082/jssm.2025.684 [doi] PST - epublish SO - J Sports Sci Med. 2025 Sep 1;24(3):684-695. doi: 10.52082/jssm.2025.684. eCollection 2025 Sep. PMID- 40931459 OWN - NLM STAT- MEDLINE DCOM- 20260615 LR - 20260922 IS - 2380-0852 (Electronic) IS - 2380-0844 (Print) IS - 2380-0844 (Linking) VI - 11 IP - 3 DP - 2026 Jul TI - Key Mediators Reducing Socioeconomic Inequality in Early Childhood Caries. PG - 444-453 LID - 10.1177/23800844251365536 [doi] AB - OBJECTIVES: Socioeconomic status (SES) has a significant effect on the burden of early childhood caries (ECC), yet addressing SES disparities remains challenging. This study aimed to identify and quantify the most impactful mediator linking SES effect to the occurrence of ECC using advanced causal mediation analysis, to inform targeted interventions that reduce SES-related disparities in ECC. METHODS: Data were drawn from the Study of Mothers' and Infants' Life Events, a cohort of 2,182 mother-child dyads recruited from Adelaide's 3 largest public hospitals (2013-2014). Baseline questionnaires captured family SES, while ECC clinical indicators were assessed at age 5 y. Three mediation pathways linking SES and ECC were examined including dietary intake represented by free sugar intake (FSI); oral hygiene practices, including toothbrushing habits and plaque presence; and dental visiting patterns. Mediation effects were quantified as natural indirect effects (NIE) using causal mediation analysis based on the counterfactual framework, with validation via 5-fold cross-validation to ensure robustness. RESULTS: FSI was the only pathway with a significant mediation effect. Each 1-standard-deviation increase or decrease in SES was associated with a corresponding 6% reduction or increase in ECC risk at age 5 y through the mediating effect of FSI at age 2 y. The NIE of FSI accounted for 52% of SES's total effect on ECC. In contrast, oral hygiene and dental visiting patterns showed no significant mediation effects. CONCLUSIONS: Reducing early childhood FSI could mitigate half of SES-related disparities in ECC. Targeted interventions focusing on FSI reduction hold promise for lowering ECC risk, with future research needed to evaluate their effectiveness.Knowledge Transfer Statement:Clinicians and policymakers should prioritize nutrition education and sugar reduction initiatives as key components of early prevention in pediatric dentistry, especially for low-SES populations. Incorporating FSI screening into routine visits enables medical and dental practitioners to educate caregivers on the impact of free sugars on dental health. FAU - Dao, A T M AU - Dao ATM AUID- ORCID: 0000-0002-1942-3009 AD - School of Dentistry, Faculty of Health and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia. AD - University of Cuu Long, Vietnam. AD - Division of Epidemiology, Department of Population and Quantitative Health Sciences, University of Massachusetts Chan Medical School, Worcester, MA, USA. FAU - Do, L G AU - Do LG AUID- ORCID: 0000-0003-3684-9949 AD - School of Dentistry, Faculty of Health and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia. FAU - Stormon, N AU - Stormon N AUID- ORCID: 0000-0003-0758-1605 AD - School of Dentistry, Faculty of Health and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia. AD - Community and Oral Health, Metro North Hospital and Health Services, Queensland, Australia. FAU - Nguyen, H V AU - Nguyen HV AD - University of Cuu Long, Vietnam. AD - Division of Epidemiology, Department of Population and Quantitative Health Sciences, University of Massachusetts Chan Medical School, Worcester, MA, USA. AD - Health Innovation and Transformation Centre (HITC), Federation University, Victoria, Australia. AD - School of Public Health, The University of Queensland. FAU - Ha, D H AU - Ha DH AD - School of Dentistry, Faculty of Health and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250910 PL - United States TA - JDR Clin Trans Res JT - JDR clinical and translational research JID - 101684997 SB - IM MH - Humans MH - *Dental Caries/epidemiology/prevention & control MH - Socioeconomic Disparities in Health MH - Child, Preschool MH - Female MH - Oral Hygiene/statistics & numerical data MH - *Social Class MH - Toothbrushing/statistics & numerical data MH - Male MH - South Australia/epidemiology MH - Infant MH - Low Socioeconomic Status MH - Socioeconomic Factors MH - Mediation Analysis PMC - PMC13232583 OTO - NOTNLM OT - causal mediation analysis (CMA) OT - dental caries OT - dental visit OT - free sugar intake OT - socioeconomic factors OT - toothbrushing COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/09/11 06:28 MHDA- 2026/06/15 12:52 PMCR- 2026/09/10 CRDT- 2025/09/11 01:13 PHST- 2026/06/15 12:52 [medline] PHST- 2025/09/11 06:28 [pubmed] PHST- 2025/09/11 01:13 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - 10.1177_23800844251365536 [pii] AID - 10.1177/23800844251365536 [doi] PST - ppublish SO - JDR Clin Trans Res. 2026 Jul;11(3):444-453. doi: 10.1177/23800844251365536. Epub 2025 Sep 10. PMID- 40929758 OWN - NLM STAT- MEDLINE DCOM- 20251130 LR - 20251201 IS - 1873-6807 (Electronic) IS - 1740-1445 (Linking) VI - 55 DP - 2025 Dec TI - Beyond appearance: Cultural and psychometric validation of the Thai broad conceptualization of beauty scale using bifactor ESEM. PG - 101964 LID - S1740-1445(25)00115-9 [pii] LID - 10.1016/j.bodyim.2025.101964 [doi] AB - Expanding conceptualizations of beauty can promote positive body image and reduce appearance-related concerns. In collectivist cultures, beauty is often perceived through both appearance and inner or social qualities. This study examined the psychometric properties of the Thai version of the Broad Conceptualization of Beauty Scale (TH-BCBS), a culturally adapted measure reflecting Thai women's inclusive beauty beliefs. The original measure (Tylka & Iannantuono, 2016) was translated and expanded to include dimensions relevant to the Thai context. A sample of 441 Thai female undergraduates completed the revised scale and other related measures. Exploratory factor analysis supported a three-factor model representing physical beauty, intrapersonal characteristics, and interpersonal characteristics. Results from an exploratory structural equation modeling revealed a well-defined general factor and a specific factor for interpersonal characteristics, despite the weaker representations of the other two. For predictive validity, the general factor predicted both body areas satisfaction and appearance evaluation. The physical beauty factor inversely predicted the drive for thinness. Convergent validity was supported by negative associations between physical beauty, thin-ideal internalization, and appearance comparison. The lack of association between body mass index and the TH-BCBS further supported the scale's discriminant validity. Overall, the TH-BCBS is a reliable and culturally grounded instrument for assessing multidimensional beauty beliefs among Thai women, with implications for future positive body image research and interventions. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - Jinchang, Kamonkan AU - Jinchang K AD - Faculty of Psychology, Chulalongkorn University, Bangkok, Thailand. Electronic address: kamonkan.j@chula.ac.th. FAU - Jarunratanakul, Prapimpa AU - Jarunratanakul P AD - Faculty of Psychology, Chulalongkorn University, Bangkok, Thailand. LA - eng PT - Journal Article PT - Validation Study DEP - 20250910 PL - Netherlands TA - Body Image JT - Body image JID - 101222431 SB - IM MH - Humans MH - Female MH - Psychometrics MH - *Body Image/psychology MH - *Beauty MH - Thailand MH - Young Adult MH - Adult MH - Reproducibility of Results MH - Adolescent MH - Surveys and Questionnaires MH - Factor Analysis, Statistical MH - Students/psychology MH - Self Concept MH - Personal Satisfaction MH - Southeast Asian People OTO - NOTNLM OT - Bifactor analysis OT - Broad conceptualization of beauty OT - Exploratory structural equation modeling OT - Positive body image OT - Psychometrics OT - Thai COIS- Declaration of Competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Kamonkan Jinchang and Prapimpa Jarunratanakul report financial support provided by the Royal Golden Jubilee Ph.D. Program. Additionally, Kamonkan Jinchang reports financial support provided by the Faculty of Psychology, Chulalongkorn University. The authors declare no other competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/09/11 00:28 MHDA- 2025/12/01 00:30 CRDT- 2025/09/10 18:01 PHST- 2025/04/26 00:00 [received] PHST- 2025/08/23 00:00 [revised] PHST- 2025/08/29 00:00 [accepted] PHST- 2025/12/01 00:30 [medline] PHST- 2025/09/11 00:28 [pubmed] PHST- 2025/09/10 18:01 [entrez] AID - S1740-1445(25)00115-9 [pii] AID - 10.1016/j.bodyim.2025.101964 [doi] PST - ppublish SO - Body Image. 2025 Dec;55:101964. doi: 10.1016/j.bodyim.2025.101964. Epub 2025 Sep 10. PMID- 40928704 OWN - NLM STAT- MEDLINE DCOM- 20250930 LR - 20260925 IS - 1468-2869 (Electronic) IS - 1099-3460 (Print) IS - 1099-3460 (Linking) VI - 102 IP - 4 DP - 2025 Aug TI - Measuring Street Built Environments for Children's Use: A Systematic Review of Measurement Tools. PG - 789-812 LID - 10.1007/s11524-025-01003-9 [doi] AB - Street-level environments play a vital role in children's development by promoting their physical activity, cognitive growth, and overall development. This study systematically reviews the measurement tools available to assess street environments according to children's needs. This systematic review was conducted according to the PRISMA-COSMIN guidelines. Five databases were searched-Science, PubMed, EBSCO, PsycINFO, and Scopus-and gray Literature was identified using Google Scholar. Inclusion and exclusion criteria were formulated to screen the retrieved articles. The studies included were assessed for risk of bias using the COSMIN RoB checklist. A total of 25 assessment tools were included. The characteristics and measurement properties of these tools are described in two main categories: audit tools and questionnaires. The elements of street built environments addressed in the tools were reflected in five domains: convenience, functionality, safety, aesthetics, and overall perception. For future research, recommendations for tool improvement are proposed, involving participant inclusion and methodological strategies, tool selection, environmental domains, and technological applications in measurement tools. These findings highlight the importance of focusing on children's unique needs when using street environment assessment tools. Future tools should integrate urban big data and computer vision technologies to support the development of child-friendly street environments. CI - (c) 2025. The New York Academy of Medicine. FAU - Cao, Xiu AU - Cao X AD - School of Architecture and Design, Harbin Institute of Technology, Harbin, 150001, China. AD - Key Laboratory of Cold Region Urban and Rural Human Settlement Environment Science and Technology, Ministry of Industry and Information Technology, Harbin, 150001, China. FAU - Meng, Xue AU - Meng X AUID- ORCID: 0000-0001-9800-9094 AD - School of Architecture and Design, Harbin Institute of Technology, Harbin, 150001, China. mengxue@hit.edu.cn. AD - Key Laboratory of Cold Region Urban and Rural Human Settlement Environment Science and Technology, Ministry of Industry and Information Technology, Harbin, 150001, China. mengxue@hit.edu.cn. FAU - Zhang, Haoyu AU - Zhang H AD - School of Architecture and Design, Harbin Institute of Technology, Harbin, 150001, China. AD - Key Laboratory of Cold Region Urban and Rural Human Settlement Environment Science and Technology, Ministry of Industry and Information Technology, Harbin, 150001, China. LA - eng GR - 52108008/National Natural Science Foundation of China/ GR - 2022M710960/China Postdoctoral Science Foundation/ PT - Journal Article PT - Systematic Review DEP - 20250910 PL - United States TA - J Urban Health JT - Journal of urban health : bulletin of the New York Academy of Medicine JID - 9809909 SB - IM MH - Humans MH - *Built Environment/standards/statistics & numerical data MH - Child MH - *Environment Design MH - Surveys and Questionnaires MH - Safety MH - Exercise PMC - PMC12484467 OTO - NOTNLM OT - Assessment OT - Audit tools OT - Built environment OT - Child OT - Street OT - Systematic review EDAT- 2025/09/10 12:32 MHDA- 2025/09/30 18:28 PMCR- 2026/08/01 CRDT- 2025/09/10 11:14 PHST- 2024/12/31 00:00 [received] PHST- 2025/08/05 00:00 [accepted] PHST- 2025/09/30 18:28 [medline] PHST- 2025/09/10 12:32 [pubmed] PHST- 2025/09/10 11:14 [entrez] PHST- 2026/08/01 00:00 [pmc-release] AID - 10.1007/s11524-025-01003-9 [pii] AID - 1003 [pii] AID - 10.1007/s11524-025-01003-9 [doi] PST - ppublish SO - J Urban Health. 2025 Aug;102(4):789-812. doi: 10.1007/s11524-025-01003-9. Epub 2025 Sep 10. PMID- 40925023 OWN - NLM STAT- MEDLINE DCOM- 20250909 LR - 20250909 IS - 2791-6421 (Electronic) IS - 0041-4301 (Linking) VI - 67 IP - 4 DP - 2025 Sep 1 TI - The reliability and validity study of the Turkish version of Brief Measure of Eating Compulsivity (MEC) among adolescents. PG - 493-500 LID - 10.24953/turkjpediatr.2025.6271 [doi] AB - BACKGROUND: Food addiction has been increasingly recognized as a contributing factor to obesity and eating disorders. Compulsive eating, characterized by an uncontrollable urge to consume food despite adverse consequences, shares behavioral similarities with substance addiction. This study aims to adapt the Brief Measure of Eating Compulsivity (MEC) into Turkish and evaluate its validity and reliability in the adolescent population. METHODS: The study included a sample of 89 adolescents aged 12-18 years. Participants without chronic medical or psychiatric conditions affecting eating behaviors were included. The adaptation process involved translation, back-translation, and expert evaluations to ensure cultural and linguistic appropriateness. The psychometric properties of the Turkish MEC were assessed through internal consistency, exploratory factor analysis, and criterion validity using the Yale Food Addiction Scale (YFAS). RESULTS: The internal consistency of the Turkish MEC was 0.89, with item-total correlations ranging from 0.56 to 0.72. Factor analysis supported a single-factor structure explaining 52.6% of the variance. Convergent validity was established through a significant positive correlation with YFAS scores (r = 0.57, p < 0.001). Criterion validity analysis demonstrated significantly higher MEC scores in individuals classified as food addicts by YFAS (p = 0.025). Additionally, significant differences in MEC scores were observed across body mass index categories (p = 0.010), with higher scores in adolescents with obesity compared to the normal-weight group. CONCLUSIONS: The Turkish version of the MEC demonstrated strong reliability and validity among adolescents, supporting its use in assessing compulsive eating behaviors. Given the increasing prevalence of obesity and eating disorders in Turkish youth, this tool provides a valuable resource for early detection and intervention in research and clinical settings. FAU - Tuzun Gun, Zeynep AU - Tuzun Gun Z AD - Division of Adolescent Medicine, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkiye. FAU - Pehlivanturk Kizilkan, Melis AU - Pehlivanturk Kizilkan M AD - Division of Adolescent Medicine, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkiye. FAU - Kanbur, Nuray AU - Kanbur N AD - Division of Adolescent Health, Department of Pediatrics, University of Ottawa, Children's Hospital of Eastern Ontario (CHEO), Ottawa, Ontario, Canada. LA - eng PT - Journal Article PT - Validation Study DEP - 20250901 PL - Turkey TA - Turk J Pediatr JT - The Turkish journal of pediatrics JID - 0417505 SB - IM MH - Humans MH - Adolescent MH - Turkey MH - Female MH - Male MH - Reproducibility of Results MH - Child MH - Psychometrics MH - *Compulsive Behavior/diagnosis/psychology MH - *Feeding Behavior/psychology MH - Surveys and Questionnaires MH - *Food Addiction/diagnosis/psychology MH - Translations OTO - NOTNLM OT - adolescents OT - compulsive eating OT - obesity COIS- The authors declare that there is no conflict of interest. EDAT- 2025/09/09 18:28 MHDA- 2025/09/09 18:29 CRDT- 2025/09/09 17:33 PHST- 2025/05/07 00:00 [received] PHST- 2025/07/18 00:00 [accepted] PHST- 2025/09/09 18:29 [medline] PHST- 2025/09/09 18:28 [pubmed] PHST- 2025/09/09 17:33 [entrez] AID - 6271 [pii] AID - 10.24953/turkjpediatr.2025.6271 [doi] PST - epublish SO - Turk J Pediatr. 2025 Sep 1;67(4):493-500. doi: 10.24953/turkjpediatr.2025.6271. PMID- 40924063 OWN - NLM STAT- MEDLINE DCOM- 20260306 LR - 20260819 IS - 1573-3610 (Electronic) IS - 0094-5145 (Print) IS - 0094-5145 (Linking) VI - 51 IP - 1 DP - 2026 Feb TI - Factors Influencing Betel Quid Chewing and Health Perceptions among the Orang Asli in Peninsular Malaysia. PG - 53-60 LID - 10.1007/s10900-025-01508-z [doi] AB - Betel quid chewing is a culturally-rooted oral health risk behavior that is prevalent in many Southeast Asian communities. Among Malaysia's indigenous community, particularly in isolated areas, data on betel quid chewing remain limited. This study investigated the influencing factors and health perceptions of betel quid use among 180 adults from a Proto-Malay Orang Asli community in Peninsular Malaysia. A validated questionnaire adapted from national health survey gathered data on demographics, betel quid chewing habits, and knowledge and attitude on betel quid use. Descriptive statistics determined prevalence and health behavior, while bivariate and multivariate logistic regressions identified associated factors. The prevalence of current betel quid chewing was 75.9%. Chewing was more common among individuals aged >/= 40, those with lower education, and those with strong family traditions of chewing. Multivariate analysis showed that older age (AOR = 1.126; 95% CI: 1.071-1.183; p < 0.001) significantly predicted current use. The findings highlight the need for culturally sensitive oral health strategies tailored to each indigenous communities. CI - (c) 2025. The Author(s). FAU - Jamil, Muhammad Adib AU - Jamil MA AUID- ORCID: 0009-0006-0356-9739 AD - Centre of Population Oral Health and Clinical Prevention, Faculty of Dentistry, Universiti Teknologi MARA (UiTM), Sungai Buloh, Selangor, 47000, Malaysia. AD - Oral Health Programme, Ministry of Health, Federal Territory of Putrajaya, Putrajaya, Malaysia. FAU - Mohd Yani, Azri Aliah AU - Mohd Yani AA AUID- ORCID: 0000-0003-0314-4838 AD - Centre of Population Oral Health and Clinical Prevention, Faculty of Dentistry, Universiti Teknologi MARA (UiTM), Sungai Buloh, Selangor, 47000, Malaysia. azrialiah@uitm.edu.my. FAU - Md Sabri, Budi Aslinie AU - Md Sabri BA AUID- ORCID: 0000-0001-9386-4761 AD - Centre of Population Oral Health and Clinical Prevention, Faculty of Dentistry, Universiti Teknologi MARA (UiTM), Sungai Buloh, Selangor, 47000, Malaysia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250909 PL - Netherlands TA - J Community Health JT - Journal of community health JID - 7600747 SB - IM MH - Humans MH - Malaysia/epidemiology MH - *Areca MH - Adult MH - Male MH - Female MH - Middle Aged MH - Young Adult MH - *Health Knowledge, Attitudes, Practice/ethnology MH - Mastication MH - Adolescent MH - Age Factors MH - Surveys and Questionnaires MH - Oral Health MH - Cross-Sectional Studies PMC - PMC12950021 OTO - NOTNLM OT - Betel quid chewing OT - Health behavior OT - Indigenous peoples OT - Oral health OT - Orang asli COIS- Declarations. Conflict of interest: All authors declare that they have no conflict of interest. Ethical Approval: This study received approval from The Research Ethics Committee of the Research Management Centre, Universiti Teknologi MARA, Malaysia and The Department of Orang Asli Development, Ministry of Rural and Regional Department, Malaysia (REC/05/2024(PG/FB/18)). EDAT- 2025/09/09 12:31 MHDA- 2026/03/06 13:47 PMCR- 2025/09/09 CRDT- 2025/09/09 11:03 PHST- 2025/08/07 00:00 [accepted] PHST- 2026/03/06 13:47 [medline] PHST- 2025/09/09 12:31 [pubmed] PHST- 2025/09/09 11:03 [entrez] PHST- 2025/09/09 00:00 [pmc-release] AID - 10.1007/s10900-025-01508-z [pii] AID - 1508 [pii] AID - 10.1007/s10900-025-01508-z [doi] PST - ppublish SO - J Community Health. 2026 Feb;51(1):53-60. doi: 10.1007/s10900-025-01508-z. Epub 2025 Sep 9. PMID- 40922428 OWN - NLM STAT- Publisher LR - 20250909 IS - 1942-7522 (Electronic) IS - 0145-5613 (Linking) DP - 2025 Sep 8 TI - Impact of Mouth Breathing on Dental Caries in Children and Its High Medical Costs. PG - 1455613251370571 LID - 10.1177/01455613251370571 [doi] AB - BACKGROUND: Mouth breathing (MB) is a pediatric public health concern potentially increasing dental caries risk. We investigated risk factors, relationships between clinical characteristics and medical costs, and their effects on caries severity. STUDY DESIGN: Observation study. SETTING: Analysis of clinical characteristics, medical costs, and dental caries in MB children. PARTICIPANTS: Eighty-six children with MB secondary to adenoid hypertrophy (AH) and/or tonsillar hypertrophy, recruited from an ENT department (June-August 2023). MEASUREMENTS: MB diagnosis via validated criteria; dental caries assessment; questionnaire on demographics, medical history, body mass index, Paediatric Yorkhill Malnutrition Score, perinatal factors, feeding practices, oral hygiene, parental education, and costs. RESULTS: Caries prevalence was 40.7% (35/86). Caries correlated significantly with longer MB duration (P = .013), higher total IgE (P = .004), and delayed toothbrushing initiation (P = .001). AH severity (assessed by Pharyngeal Airway Space, P = .013; choanal obstruction grade, P = .006) correlated with caries. Non-caries children showed higher breastfeeding rates (P = .026). Multivariate analysis identified formula feeding (odds ratio (OR) = 10.099, P = .026), longer disease duration (OR = 1.495, P = .035), and delayed oral hygiene initiation (OR = 2.171, P = .025) as independent caries predictors. Medical costs positively correlated with maternal education (r = 0.280, P = .009), AH grade (r = 0.345, P = .001), disease duration (r = 0.383, P < .001), and prematurity (r = 0.457, P < .0001), with maternal education exerting the strongest cost influence. Delayed toothbrushing (r = 0.213) and formula feeding (r = 0.219) positively correlated with higher decayed, missing, filled teeth/decayed, missing, or filled surfaces (affected surfaces) indices. CONCLUSION: MB-associated caries is highly prevalent and costly. Multiple modifiable risk factors contribute to its occurrence in children. FAU - Deng, Huiyi AU - Deng H AUID- ORCID: 0000-0001-9046-5351 AD - Department of Otorhinolaryngology-Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. AD - Department of Allergy, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. FAU - Zhao, Chenyu AU - Zhao C AD - Stomatology Center, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. FAU - Yang, Qintai AU - Yang Q AD - Department of Otorhinolaryngology-Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. AD - Department of Allergy, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. FAU - Huang, Xuekun AU - Huang X AD - Department of Otorhinolaryngology-Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. AD - Department of Allergy, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. LA - eng PT - Journal Article DEP - 20250908 PL - United States TA - Ear Nose Throat J JT - Ear, nose, & throat journal JID - 7701817 SB - IM OTO - NOTNLM OT - dental caries OT - dmf OT - medical cost OT - mouth breathing OT - risk factor EDAT- 2025/09/09 06:35 MHDA- 2025/09/09 06:35 CRDT- 2025/09/09 01:43 PHST- 2025/09/09 06:35 [medline] PHST- 2025/09/09 06:35 [pubmed] PHST- 2025/09/09 01:43 [entrez] AID - 10.1177/01455613251370571 [doi] PST - aheadofprint SO - Ear Nose Throat J. 2025 Sep 8:1455613251370571. doi: 10.1177/01455613251370571. PMID- 40922132 OWN - NLM STAT- MEDLINE DCOM- 20251229 LR - 20260113 IS - 1535-1815 (Electronic) IS - 0749-5161 (Linking) VI - 42 IP - 1 DP - 2026 Jan 1 TI - A Pilot Study Using Casino Shifts to Improve Sleep for Emergency Medicine Fellows Working Night Shifts. PG - 22-27 LID - 10.1097/PEC.0000000000003477 [doi] AB - OBJECTIVES: Casino shifts, which end at 4 AM and allow sleep during the circadian "anchor period," may improve sleep and reduce fatigue for pediatric emergency medicine (PEM) fellows working night shifts. We hypothesized that using a casino shift model would improve perceived fatigue levels and measured sleep metrics. METHODS: In this pilot prospective observational cohort study, fellows worked traditional night shifts for one month (control) followed by casino shifts for one month (intervention). Sleep data were collected using a validated wrist actigraph (ReadiBand), and subjective perceptions of fatigue were collected using surveys. RESULTS: Eight fellows participated in the study. Compared with the control month, the intervention month was associated with increased sleep quantity and sleep efficiency as measured by the actigraph. Fellows also reported reduced perceived fatigue and improved energy levels during the intervention month. CONCLUSIONS: Switching to a casino shift schedule was associated with improvements in measured sleep and perceived fatigue among a cohort of PEM fellows in this pilot study. These preliminary findings warrant further investigation with larger samples and randomized scheduling to further explore the potential benefits and limitations of casino shift models in emergency medicine. CI - Copyright (c) 2025 Wolters Kluwer Health, Inc. All rights reserved. FAU - Cohen, Erika AU - Cohen E AD - Department of Pediatrics-Emergency Medicine, The University of Tennessee Health Science Center, Memphis, TN. FAU - Jacobs, Jonathan AU - Jacobs J FAU - Kink, Rudy J AU - Kink RJ LA - eng GR - Innovation Grant For Quality Improvement/ PT - Journal Article PT - Observational Study DEP - 20250910 PL - United States TA - Pediatr Emerg Care JT - Pediatric emergency care JID - 8507560 SB - IM MH - Humans MH - Pilot Projects MH - Prospective Studies MH - Male MH - Female MH - Fatigue/prevention & control MH - *Work Schedule Tolerance/physiology MH - *Emergency Medicine/education MH - *Shift Work Schedule MH - *Sleep/physiology MH - Actigraphy MH - Adult MH - Internship and Residency OTO - NOTNLM OT - casino shift OT - fatigue OT - pediatric emergency medicine OT - sleep COIS- Disclosure: The authors declare no conflict of interest. EDAT- 2025/09/09 06:34 MHDA- 2025/12/30 00:30 CRDT- 2025/09/09 00:53 PHST- 2025/05/07 00:00 [received] PHST- 2025/08/07 00:00 [accepted] PHST- 2025/12/30 00:30 [medline] PHST- 2025/09/09 06:34 [pubmed] PHST- 2025/09/09 00:53 [entrez] AID - 00006565-990000000-00719 [pii] AID - 10.1097/PEC.0000000000003477 [doi] PST - ppublish SO - Pediatr Emerg Care. 2026 Jan 1;42(1):22-27. doi: 10.1097/PEC.0000000000003477. Epub 2025 Sep 10. PMID- 40919778 OWN - NLM STAT- MEDLINE DCOM- 20251215 LR - 20260616 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) VI - 36 IP - 8 DP - 2025 Nov-Dec 01 TI - The Value and Reliability of Traditional Anthropometric Measurements of Cranial Deformity. PG - e1324-e1327 LID - 10.1097/SCS.0000000000011912 [doi] AB - Positional cranial deformities are frequently observed in early infancy. The lack of a clinically proven measure to quantify the severity and change of positional cranial deformities makes the treatment of cranial deformities controversial. The use of anthropometric measurements is a recommended method. Although anthropometric measurements with calipers have controversial anthropometric measurement values in the literature, it remains the most practical and cheapest tool for deciding on a cranial helmet and monitoring the effectiveness of the helmet. In this study, the reliability and validity of this measurement method were investigated. Traditional anthropometric measurements of the infants' heads were taken by one researcher while the second researcher scanned the infant's head and determined the anthropometric values in the scan. Cranial measurements of metal calipers, 3D calipers and scan data using the TALEE program were compared in infants diagnosed with plagiocephaly, brachycephaly, and asymmetric brachycephaly. Right ft-left ld, left ft-right ld, left ft-right ld, cranial width and length values were evaluated as measurement parameters and mean, SD, variance, and Pearson correlation coefficients were calculated for each measurement method. It was found that the highest consistency was obtained in the cranial width measurement, followed by left ft-right ld and cranial length measurements, respectively. A high correlation ( r >0.90, P <0.01) was found between the 3D caliper and TALEE measurements in the asymmetric brachycephaly group, while the 3D caliper showed lower variability in the plagiocephaly and brachycephaly groups. When the mean and SD values were analyzed, no statistically significant difference was found between metal caliper and 3D caliper measurements. It is thought that the 3D caliper method may provide more reliable and consistent measurements in cranial deformity evaluations and may be preferred for clinical use, especially in asymmetric deformities. CI - Copyright (c) 2025 by Mutaz B. Habal, MD. FAU - Uncu, Aslinur AU - Uncu A AUID- ORCID: 0009-0007-1647-1850 AD - Ankara University, Faculty of Health Sciences. FAU - Alsancak, Serap AU - Alsancak S AD - Ankara University, Faculty of Health Sciences. FAU - Onganlar, Yasar Huseyin AU - Onganlar YH AD - Yasar Huseyin Onganlar Private Clinic, Ankara, Turkey. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250908 PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 SB - IM MH - Humans MH - *Cephalometry/methods/instrumentation MH - Reproducibility of Results MH - Infant MH - Male MH - Female MH - *Skull/abnormalities MH - *Craniosynostoses/pathology MH - Plagiocephaly/diagnostic imaging MH - *Anthropometry/methods MH - Imaging, Three-Dimensional OTO - NOTNLM OT - 3D caliper OT - Positional cranial deformity OT - anthropometric measurement reliability OT - metal caliper COIS- The authors report no conflicts of interest. EDAT- 2025/09/08 12:43 MHDA- 2025/12/15 13:10 CRDT- 2025/09/08 08:03 PHST- 2025/08/01 00:00 [received] PHST- 2025/08/10 00:00 [accepted] PHST- 2025/12/15 13:10 [medline] PHST- 2025/09/08 12:43 [pubmed] PHST- 2025/09/08 08:03 [entrez] AID - 00001665-202511000-00122 [pii] AID - 10.1097/SCS.0000000000011912 [doi] PST - ppublish SO - J Craniofac Surg. 2025 Nov-Dec 01;36(8):e1324-e1327. doi: 10.1097/SCS.0000000000011912. Epub 2025 Sep 8. PMID- 40917734 OWN - NLM STAT- In-Process LR - 20250910 IS - 1179-1411 (Print) IS - 1179-1411 (Electronic) IS - 1179-1411 (Linking) VI - 17 DP - 2025 TI - The Impact of Age at First Sexual Intercourse on Female Reproductive Disorders: A Mendelian Randomized Study. PG - 2833-2844 LID - 10.2147/IJWH.S534178 [doi] AB - BACKGROUND: Female reproductive disorders (FRDs) are common diseases among women of childbearing age, affecting their reproductive health. Age at first sexual intercourse (AFS) is potentially linked to FRDs, and this study aims to investigate these associations and underlying mechanisms, to offer new insights and guidance for sex education in adolescent women and reproductive health management. METHODS: Mendelian randomization (MR) analysis was performed using summary data from genome-wide association studies (GWASs). The AFS summary data were sourced from 397,338 European participants, and the outcome data were obtained from the FinnGen consortium. Additionally, multivariate MR (MVMR) and mediation analyses were also adopted to explore more detailed association. The MR results were rigorously validated, with the inverse variance weighted (IVW) method employed as the primary approach to assess causal relationships. RESULTS: There is a significant causal relationship between AFS and ovarian dysfunction (OD), polycystic ovarian syndrome (PCOS), and spontaneous abortion (0.45 [0.25-0.81], p=0.008; 0.35 [0.17-0.74], p=0.006; 0.76 [0.63-0.92], p=0.006). Among them, the genetic association between AFS and spontaneous abortion remained significant even after adjusting for more confounding variables (0.73 [0.55-0.95], p=0.020; 0.76 [0.61-0.95], p=0.015), and Body mass index (BMI) may be an important mediating factor in the association between AFS and PCOS (38.41%, p=7.17e-6) or OD (35.64%, p= 1.51e-6). CONCLUSION: Our research suggested that early AFS is closely associated with a higher risk of reproductive disorders, and timely interventions targeting BMI may partially alleviate the adverse effects of early sexual activity on reproductive health. The analysis based on genetic data emphasizes the importance of early sex education for adolescents, while weight management can to some extent avoid the occurrence of reproductive disorders during childbearing age, which also provide scientific basis for understanding the pathogenesis of FRDs and formulating appropriate reproductive health education strategies. CI - (c) 2025 Xin et al. FAU - Xin, Xin AU - Xin X AUID- ORCID: 0009-0000-7328-3193 AD - Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200052, People's Republic of China. AD - Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China. FAU - Guan, Lu AU - Guan L AD - Shandong University of Traditional Chinese Medicine, Jinan, 250011, People's Republic of China. FAU - Li, Jiaxi AU - Li J AD - Shandong Wendeng Osteopathic Hospital, Wendeng, Shandong, 264400, People's Republic of China. FAU - Zhang, Jinfu AU - Zhang J AD - Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200052, People's Republic of China. AD - Shanghai University of Traditional Chinese Medicine, Shenzhen Hospital, Shenzhen, Guangdong, 518001, People's Republic of China. FAU - Wu, Haicui AU - Wu H AD - Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250014, People's Republic of China. LA - eng PT - Journal Article DEP - 20250902 PL - New Zealand TA - Int J Womens Health JT - International journal of women's health JID - 101531698 PMC - PMC12413823 OTO - NOTNLM OT - Mendelian randomization OT - age at first sexual intercourse OT - body mass index OT - female reproductive disorders OT - mediation effect OT - spontaneous abortion COIS- The authors declare that they have no conflicts of interest in this work. EDAT- 2025/09/08 12:44 MHDA- 2025/09/08 12:44 PMCR- 2025/09/02 CRDT- 2025/09/08 07:03 PHST- 2025/05/21 00:00 [received] PHST- 2025/08/27 00:00 [accepted] PHST- 2025/09/08 12:44 [medline] PHST- 2025/09/08 12:44 [pubmed] PHST- 2025/09/08 07:03 [entrez] PHST- 2025/09/02 00:00 [pmc-release] AID - 534178 [pii] AID - 10.2147/IJWH.S534178 [doi] PST - epublish SO - Int J Womens Health. 2025 Sep 2;17:2833-2844. doi: 10.2147/IJWH.S534178. eCollection 2025. PMID- 40916137 OWN - NLM STAT- MEDLINE DCOM- 20251001 LR - 20251001 IS - 1465-3478 (Electronic) IS - 0963-7486 (Linking) VI - 76 IP - 6 DP - 2025 Sep TI - Associations between dietary patterns derived using principal component analysis and personality traits in adults: a cross-sectional study. PG - 654-665 LID - 10.1080/09637486.2025.2554614 [doi] AB - The present study explored associations between the five personality traits (Extraversion, Agreeableness, Conscientiousness, Neuroticism, and Openness) and dietary patterns of apparently healthy individuals. Demographic, anthropometric, dietary, and personality data were obtained from 480 adults, up to 45 years of age, through self-completed questionnaires. Dietary habits were assessed via a validated for the population Food Frequency Questionnaire (FFQ), whereas personality was evaluated with the validated Greek version of the 50-item International Personality Item Pool (IPIP). Five dietary patterns were derived from the principal component analysis: the processed foods, the plant-based, the Western-type, the healthy, and the alcohol-coffee pattern. Regression analysis revealed significant findings for various dietary patterns. For the alcohol-coffee pattern, neuroticism showed a positive correlation in the 18-24 age group. In the healthy dietary pattern, BMI and openness were positive predictors, with age predicting healthy eating in participants with under- and normal weight. For the plant-based pattern, male gender was a negative predictor, while openness was positive. For the western-type pattern, male gender was a positive predictor, whereas age and neuroticism negatively predicted adherence in females. Age and conscientiousness negatively predicted the processed foods dietary pattern. More research is needed in this field. FAU - Micheli, Mary AU - Micheli M AUID- ORCID: 0009-0003-1124-3091 AD - Department of BSc (Hons) Dietetics, Metropolitan College, Athens, Greece. FAU - Takousi, Maria AU - Takousi M AUID- ORCID: 0000-0001-5215-9783 AD - Department of BSc (Hons) Dietetics, Metropolitan College, Athens, Greece. FAU - Skordis, Marios AU - Skordis M AUID- ORCID: 0009-0000-7219-1692 AD - Department of BSc (Hons) Dietetics, Metropolitan College, Athens, Greece. FAU - Kalogirou, Anastasios AU - Kalogirou A AD - Department of MSc Clinical and Community Psychology, Metropolitan College, Athens, Greece. FAU - Karpodini, Claire Chrysanthi AU - Karpodini CC AUID- ORCID: 0009-0009-4980-3596 AD - Department of Sports Coaching and Physical Education, Metropolitan College, Athens, Greece. FAU - Giannopoulou, Chrysoula Sylia AU - Giannopoulou CS AD - Department of MA Counselling and Psychotherapy, Metropolitan College, Athens, Greece. FAU - Koutoulogenis, Konstantinos AU - Koutoulogenis K AUID- ORCID: 0000-0003-0778-6694 AD - Department of BSc (Hons) Dietetics, Metropolitan College, Athens, Greece. FAU - Fappa, Evaggelia AU - Fappa E AUID- ORCID: 0000-0002-7960-3378 AD - Department of BSc (Hons) Dietetics, Metropolitan College, Athens, Greece. LA - eng PT - Journal Article DEP - 20250907 PL - England TA - Int J Food Sci Nutr JT - International journal of food sciences and nutrition JID - 9432922 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - *Personality MH - Cross-Sectional Studies MH - Middle Aged MH - Principal Component Analysis MH - Young Adult MH - *Diet MH - *Feeding Behavior MH - Adolescent MH - Surveys and Questionnaires MH - Diet, Healthy MH - Neuroticism MH - Body Mass Index OTO - NOTNLM OT - Big Five model OT - Personality traits OT - adults OT - dietary patterns OT - healthy eating EDAT- 2025/09/08 06:32 MHDA- 2025/10/01 12:31 CRDT- 2025/09/08 00:23 PHST- 2025/10/01 12:31 [medline] PHST- 2025/09/08 06:32 [pubmed] PHST- 2025/09/08 00:23 [entrez] AID - 10.1080/09637486.2025.2554614 [doi] PST - ppublish SO - Int J Food Sci Nutr. 2025 Sep;76(6):654-665. doi: 10.1080/09637486.2025.2554614. Epub 2025 Sep 7. PMID- 40915336 OWN - NLM STAT- MEDLINE DCOM- 20251201 LR - 20260707 IS - 1878-5476 (Electronic) IS - 1878-5476 (Linking) VI - 82 DP - 2026 Jan TI - Development of the multidimensional inventory of physical activity identity. PG - 102990 LID - S1469-0292(25)00189-X [pii] LID - 10.1016/j.psychsport.2025.102990 [doi] AB - Identity is among the most robust psychological constructs for predicting whether individuals translate physical activity (PA) intentions into action. However, existing identity measures in the PA domain focus narrowly on exercise and largely adopt limited unidimensional conceptualizations. This study aimed to develop and validate the Multidimensional Inventory of Physical Activity Identity (MIPAI-25), a novel instrument grounded in a multidimensional, theoretically integrated framework. Across two samples of university students (Study 1: n = 580, 61.6 % women; Study 2: n = 619, 66.4 % women), we used classical test theory, Mokken scale analysis, and item response theory to construct and refine the content relevancy of the items for each scale. In Study 1, the final 25-item instrument captures five distinct dimensions of PA identity: Acknowledgment, Compatibility, Centrality, Commitment, and Exploration. Each subscale score demonstrated strong internal consistency, unidimensionality, and measurement invariance across gender groups. In Study 2, all five dimensions were positively associated with moderate-to-vigorous PA behavior and PA-related constructs from the Multi-Process Action Control framework, with the strongest associations observed for habit and behavioral regulation - key post-intentional processes that facilitate action control. The MIPAI-25 offers a more ecologically valid and dynamic representation of PA identity, extending beyond exercise-specific and unidimensional measures. Findings support its use as both a comprehensive tool and a set of five stand-alone subscales, depending on research or practical needs. Future longitudinal studies are needed to explore how these identity dimensions evolve across life transitions and to inform more targeted, identity-based interventions for promoting sustained physical activity. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - Brown, Denver M Y AU - Brown DMY AD - Department of Kinesiology, Kansas State University, Manhattan, KS, USA. Electronic address: denverbrown@ksu.edu. FAU - Meca, Alan AU - Meca A AD - Department of Psychology, The University of Texas at San Antonio, San Antonio, TX, USA. FAU - Osman, Augustine AU - Osman A AD - Department of Psychology, The University of Texas at San Antonio, San Antonio, TX, USA. LA - eng PT - Journal Article DEP - 20250905 PL - Netherlands TA - Psychol Sport Exerc JT - Psychology of sport and exercise JID - 101088724 SB - IM MH - Humans MH - Female MH - Male MH - *Exercise/psychology MH - Young Adult MH - Adult MH - Surveys and Questionnaires MH - Adolescent MH - Psychometrics MH - *Self Concept MH - Students/psychology MH - Intention MH - Reproducibility of Results OTO - NOTNLM OT - Instrument development OT - Item response theory OT - Psychometrics OT - Self-schema COIS- Declaration of competing interest The authors have no conflicts to disclose. EDAT- 2025/09/08 00:33 MHDA- 2025/12/02 01:00 CRDT- 2025/09/07 19:11 PHST- 2025/04/30 00:00 [received] PHST- 2025/07/25 00:00 [revised] PHST- 2025/09/02 00:00 [accepted] PHST- 2025/12/02 01:00 [medline] PHST- 2025/09/08 00:33 [pubmed] PHST- 2025/09/07 19:11 [entrez] AID - S1469-0292(25)00189-X [pii] AID - 10.1016/j.psychsport.2025.102990 [doi] PST - ppublish SO - Psychol Sport Exerc. 2026 Jan;82:102990. doi: 10.1016/j.psychsport.2025.102990. Epub 2025 Sep 5. PMID- 40914767 OWN - NLM STAT- MEDLINE DCOM- 20260130 LR - 20260619 IS - 1476-5497 (Electronic) IS - 0307-0565 (Print) IS - 0307-0565 (Linking) VI - 50 IP - 1 DP - 2026 Jan TI - Socioeconomic differences in the cost-effectiveness of a telephone-based intervention for obesity prevention in early childhood. PG - 152-158 LID - 10.1038/s41366-025-01904-4 [doi] AB - OBJECTIVES: This study investigated the cost-effectiveness of an early childhood obesity prevention intervention providing telephone and short message service (SMS) support to mothers of children aged 2-4 years by socioeconomic position (SEP). METHODS: A model-based SEP-specific economic evaluation of the intervention was conducted. SEP-specific intervention costs and effects at age 5 years were derived from the trial data and applied to a cohort of 4- to 5-year-old Australian children. We used the validated EQ-EPOCH microsimulation model to predict SEP-specific body mass index (BMI) trajectories, quality-adjusted life years (QALYs) and health care costs until 17 years of age. Incremental cost-effectiveness ratios (ICERs) and acceptability curves were derived for each SEP group, using 2023 Australian dollars (AUD). RESULTS: From an Australian health payer perspective, the ICERs for the low-SEP group were $131 per BMI unit avoided and $6549 per QALY gained, compared to the high-SEP group at $1161 per BMI unit avoided and $41,462 per QALY gained. Results were robust to sensitivity analyses varying the intervention effect size, intervention costs, healthcare costs, discount rate and disutility from overweight. The probability that the intervention was cost-effective at a willingness-to-pay threshold of $50,000 per QALY gained was extremely high in the low-SEP group (99.7%) and marginally cost-effective in the high-SEP group (49.6%). CONCLUSIONS: A telephone and SMS intervention was more cost-effective in low-SEP groups compared with high-SEP groups. Prioritizing families from socioeconomically disadvantaged backgrounds for this intervention will reduce healthy weight inequalities in childhood. CI - (c) 2025. The Author(s). FAU - Lung, Thomas AU - Lung T AUID- ORCID: 0000-0001-9978-6311 AD - Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. AD - The George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia. FAU - Hayes, Alison AU - Hayes A AUID- ORCID: 0000-0002-8679-6040 AD - Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. AD - Leeder Centre for Health Policy, Economics, and Data, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. FAU - Wen, Li Ming AU - Wen LM AUID- ORCID: 0000-0003-1381-4022 AD - Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. AD - Health Promotion Unit, Population Health Research & Evaluation Hub, Sydney Local Health District, Sydney, NSW, Australia. AD - Sydney Institute for Women, Children and Their Families, Sydney Local Health District, Sydney, NSW, Australia. FAU - Xu, Huilan AU - Xu H AD - Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. AD - Health Promotion Unit, Population Health Research & Evaluation Hub, Sydney Local Health District, Sydney, NSW, Australia. AD - Sydney Institute for Women, Children and Their Families, Sydney Local Health District, Sydney, NSW, Australia. FAU - Brown, Vicki AU - Brown V AUID- ORCID: 0000-0003-2891-9476 AD - Deakin Health Economics, Institute for Health Transformation, School of Health and Social Development, Deakin University, Geelong, VIC, Australia. FAU - Baur, Louise A AU - Baur LA AUID- ORCID: 0000-0002-4521-9482 AD - Sydney Medical School, The University of Sydney, Sydney, NSW, Australia. AD - Prevention Research Collaboration, Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. AD - Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia. FAU - Phongsavan, Philayrath AU - Phongsavan P AD - Prevention Research Collaboration, Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. AD - Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia. FAU - Killedar, Anagha AU - Killedar A AUID- ORCID: 0000-0003-2363-8827 AD - Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. anagha.killedar@sydney.edu.au. AD - Leeder Centre for Health Policy, Economics, and Data, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. anagha.killedar@sydney.edu.au. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250906 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 SB - IM MH - Humans MH - Cost-Benefit Analysis MH - *Pediatric Obesity/prevention & control/economics/epidemiology MH - Child, Preschool MH - Australia/epidemiology MH - Female MH - *Telephone MH - Male MH - Socioeconomic Factors MH - Quality-Adjusted Life Years MH - Body Mass Index MH - Mothers PMC - PMC12855013 COIS- Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: All methods were performed in accordance with the relevant guidelines and regulations. The trial was granted ethics approval by the Ethics Review Committee of Sydney Local Health District (Protocol No. X16-0360 & LNR/16/RPAH/495 and Protocol No X18-0387 & HREC/18/RPAH/545). Written informed consent was obtained from all study participants. The original RCT is registered with the Australian Clinical Trial Registry (ACTRN12618001571268). This article used unit record data from Growing Up in Australia, the Longitudinal Study of Australian Children (LSAC). Informed consent was obtained from all participants of LSAC, to use their data to further the understanding of child and adolescent development and wellbeing. EDAT- 2025/09/07 00:37 MHDA- 2026/01/30 06:29 PMCR- 2025/09/06 CRDT- 2025/09/06 23:33 PHST- 2025/02/26 00:00 [received] PHST- 2025/08/28 00:00 [accepted] PHST- 2025/08/07 00:00 [revised] PHST- 2026/01/30 06:29 [medline] PHST- 2025/09/07 00:37 [pubmed] PHST- 2025/09/06 23:33 [entrez] PHST- 2025/09/06 00:00 [pmc-release] AID - 10.1038/s41366-025-01904-4 [pii] AID - 1904 [pii] AID - 10.1038/s41366-025-01904-4 [doi] PST - ppublish SO - Int J Obes (Lond). 2026 Jan;50(1):152-158. doi: 10.1038/s41366-025-01904-4. Epub 2025 Sep 6. PMID- 40911368 OWN - NLM STAT- In-Process LR - 20260919 IS - 1555-905X (Electronic) IS - 1555-9041 (Print) IS - 1555-9041 (Linking) VI - 20 IP - 11 DP - 2025 Nov 1 TI - Association of Dietary Micronutrient Intake and the Metabolome in Children with CKD. PG - 1536-1548 LID - 10.2215/CJN.0000000811 [doi] AB - KEY POINTS: Given the role of diet in kids and micronutrients as cofactors, dietary micronutrient intake and its effect on the metabolome merit further study. Many children with CKD have intake below dietary reference intake of at least one micronutrient despite normal body mass index. Dietary intake of vitamins D and B12 had the greatest associations with plasma metabolites, particularly belonging to lipid pathways. BACKGROUND: Children with CKD experience poor growth and development through multiple mechanisms. We aimed to describe deficiencies in dietary micronutrient intake and associate dietary micronutrient intake with metabolic pathways. METHODS: The CKD in Children cohort study enrolled participants 6 months to 16 years with CKD stages 2-4 across North America. Micronutrient intake (three trace minerals, eight water-soluble vitamins, and four fat-soluble vitamins) was quantified by food frequency questionnaires at 6-month, 2-year and 4-year visits. Blood was collected at those time points for untargeted metabolomic profiling. Associations between 990 plasma metabolite features and dietary micronutrient intake were quantified with multiple linear regression using mixed effects regression models. RESULTS: There were 575 participants with available data at the 6-month visit (mean age 12 years, 39% female, eGFR 53 ml/min per 1.73 m(2), body mass index Z-score 0.7). The most common deficiency of micronutrient intake was vitamin D (90% of participants), followed by vitamin E (77%), and more than 45% of participants did not meet the dietary reference intake of iron and folate. Children with lower eGFR had lower intake of zinc and vitamins B5 and B6. Micronutrient intake was associated with 99 total and 42 unique metabolites. Dietary intake of vitamins D and B12 was associated with many metabolites involved in lipid superpathways and phosphatidylcholine, plasmalogen, and lysophospholipid subpathways. Dietary intake of iron, folate, and vitamins C, A, and K was associated with metabolites primarily belonging to the xenobiotic, cofactor/vitamin, and amino acid superpathways. The strongest associations between dietary micronutrient intake and plasma metabolites were between intake of vitamin C with stachydrine and 3-hydroxystachydrine. CONCLUSIONS: Most children with CKD have intake below dietary reference intake of at least one micronutrient despite normal body mass index, which was associated with alterations in lipid metabolism. CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: The validation cohort, "Vitamin D Supplementation in Glomerular Disease (D-FINE)," was registered with clinicaltrials.gov, NCT01835639. FAU - Hasson, Denise C AU - Hasson DC AUID- ORCID: 0000-0001-6172-4756 AD - Department of Pediatrics, Hassenfeld Children's Hospital at NYU Langone Health, New York, New York. FAU - Surapaneni, Aditya AU - Surapaneni A AUID- ORCID: 0000-0003-4978-5980 AD - Department of Precision Medicine, NYU Langone Health, New York, New York. FAU - Rebholz, Casey M AU - Rebholz CM AUID- ORCID: 0000-0002-5442-8745 AD - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. FAU - Greenberg, Jason H AU - Greenberg JH AUID- ORCID: 0000-0001-5874-1109 AD - Department of Pediatrics, Children's Hospital Yale New Haven Health, New Haven, Connecticut. FAU - Goncalves, Marcus AU - Goncalves M AUID- ORCID: 0000-0002-0784-9248 AD - Department of Medicine, NYU Langone Health, New York, New York. FAU - Ng, Derek K AU - Ng DK AUID- ORCID: 0000-0001-5878-5101 AD - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. FAU - Lee, Arthur M AU - Lee AM AUID- ORCID: 0000-0002-4969-3632 AD - Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. FAU - Furth, Susan L AU - Furth SL AD - Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. AD - Department of Pediatrics, Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. FAU - Denburg, Michelle R AU - Denburg MR AD - Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. AD - Department of Pediatrics, Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. FAU - Grams, Morgan E AU - Grams ME AUID- ORCID: 0000-0002-4430-6023 AD - Department of Precision Medicine, NYU Langone Health, New York, New York. CN - CKiD Study Investigators LA - eng GR - K38 HL169660/HL/NHLBI NIH HHS/United States GR - U01 DK106982/DK/NIDDK NIH HHS/United States GR - U01 DK103225/DK/NIDDK NIH HHS/United States GR - R01DK135650 and R01DK135518/DK/NIDDK NIH HHS/United States GR - R01 DK135650/DK/NIDDK NIH HHS/United States GR - U54 DK137331/DK/NIDDK NIH HHS/United States GR - R38 HL143613/HL/NHLBI NIH HHS/United States GR - U01 DK085689/DK/NIDDK NIH HHS/United States GR - R21 AT009752/AT/NCCIH NIH HHS/United States GR - U24 DK137522/DK/NIDDK NIH HHS/United States GR - U01 DK066143/DK/NIDDK NIH HHS/United States GR - U01 DK066174/DK/NIDDK NIH HHS/United States GR - R01 DK135518/DK/NIDDK NIH HHS/United States GR - K26 DK138375/DK/NIDDK NIH HHS/United States GR - U24 DK066116/DK/NIDDK NIH HHS/United States GR - U01 DK066143, U01 DK066174, U24 DK137522, U24 DK066116, U01 DK106982, U01DK085689, U01 DK103225, R21 AT009752, R38 HL143613-03, K38HL169660-01/DK/NIDDK NIH HHS/United States GR - R01 HL153178/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20250905 PL - United States TA - Clin J Am Soc Nephrol JT - Clinical journal of the American Society of Nephrology : CJASN JID - 101271570 SB - IM CIN - doi: 10.2215/CJN.0000000908 PMC - PMC12614852 MID - NIHMS2164100 OTO - NOTNLM OT - CKD nondialysis OT - metabolomics OT - mineral metabolism OT - nutrition OT - pediatric nephrology OT - vitamin B1 OT - vitamin C OT - vitamin D COIS- Disclosure forms, as provided by each author, are available with the online version of the article at http://links.lww.com/CJN/C406. FIR - Fathallah-Shaykh, Sahar IR - Fathallah-Shaykh S FIR - Nayak, Anjali IR - Nayak A FIR - Barletta, Gina-Marie IR - Barletta GM FIR - Blydt-Hansen, Tom IR - Blydt-Hansen T FIR - Dionne, Janis IR - Dionne J FIR - Wong, Cynthia IR - Wong C FIR - Yadin, Ora IR - Yadin O FIR - Ingulli, Elizabeth IR - Ingulli E FIR - Mak, Robert IR - Mak R FIR - Sanchez-Kazi, Cheryl IR - Sanchez-Kazi C FIR - Moudgil, Asha IR - Moudgil A FIR - Bhatnagar, Sonal IR - Bhatnagar S FIR - Abitbol, Carolyn IR - Abitbol C FIR - DeFrietas, Marissa IR - DeFrietas M FIR - Katsoufis, Chryso IR - Katsoufis C FIR - Seeherunvong, Wacharee IR - Seeherunvong W FIR - Greenbaum, Larry IR - Greenbaum L FIR - Harshman, Lyndsay IR - Harshman L FIR - Verghese, Priya IR - Verghese P FIR - Krishnan, Sonia IR - Krishnan S FIR - Wilson, Amy IR - Wilson A FIR - Kiessling, Stefan IR - Kiessling S FIR - Murphy, Margaret IR - Murphy M FIR - Shah, Siddharth IR - Shah S FIR - Sullivan, Janice IR - Sullivan J FIR - El-Dahr, Samir IR - El-Dahr S FIR - Drury, Stacy IR - Drury S FIR - Rodig, Nancy IR - Rodig N FIR - Dart, Allison IR - Dart A FIR - Atkinson, Meredith IR - Atkinson M FIR - Modi, Zubin IR - Modi Z FIR - Thomas, Jason IR - Thomas J FIR - Warady, Bradley IR - Warady B FIR - Johnson, Rebecca IR - Johnson R FIR - Dharnidharka, Vikas IR - Dharnidharka V FIR - Hooper, Stephen IR - Hooper S FIR - Massengill, Susan IR - Massengill S FIR - Gomez-Mendez, Liliana IR - Gomez-Mendez L FIR - Hand, Matthew IR - Hand M FIR - Carlson, Joann IR - Carlson J FIR - Wong, Craig IR - Wong C FIR - Kaskel, Frederick IR - Kaskel F FIR - Shinnar, Shlomo IR - Shinnar S FIR - Saland, Jeffrey IR - Saland J FIR - Levy, Rebecca IR - Levy R FIR - Lande, Marc IR - Lande M FIR - Schwartz, George IR - Schwartz G FIR - Mongia, Anil IR - Mongia A FIR - Claes, Donna IR - Claes D FIR - Mitsnefes, Mark IR - Mitsnefes M FIR - MacRae Dell, Katherine IR - MacRae Dell K FIR - Patel, Hiren IR - Patel H FIR - Yamaguchi, Ikuyo IR - Yamaguchi I FIR - Parekh, Rulan IR - Parekh R FIR - Al-Uzri, Amira IR - Al-Uzri A FIR - Richardson, Kelsey IR - Richardson K FIR - Furth, Susan IR - Furth S FIR - Copelovitch, Larry IR - Copelovitch L FIR - Hartung, Erum IR - Hartung E FIR - Ku, Elaine IR - Ku E FIR - Samuels, Joshua IR - Samuels J FIR - Srivaths, Poyyapakkam IR - Srivaths P FIR - Becker, Amy IR - Becker A FIR - Mohtat, Davoud IR - Mohtat D FIR - Norwood, Victoria IR - Norwood V FIR - Flynn, Joseph IR - Flynn J FIR - Halbach, Susan IR - Halbach S FIR - Sreedharan, Rajasree IR - Sreedharan R FIR - Bartosh, Sharon IR - Bartosh S EDAT- 2025/09/05 12:40 MHDA- 2025/09/05 12:40 PMCR- 2025/11/01 CRDT- 2025/09/05 12:04 PHST- 2025/05/01 00:00 [received] PHST- 2025/09/02 00:00 [accepted] PHST- 2025/09/05 12:40 [pubmed] PHST- 2025/09/05 12:40 [medline] PHST- 2025/09/05 12:04 [entrez] PHST- 2025/11/01 00:00 [pmc-release] AID - 01277230-202511000-00010 [pii] AID - CJASN-2025-000718 [pii] AID - 10.2215/CJN.0000000811 [doi] PST - ppublish SO - Clin J Am Soc Nephrol. 2025 Nov 1;20(11):1536-1548. doi: 10.2215/CJN.0000000811. Epub 2025 Sep 5. PMID- 40910865 OWN - NLM STAT- MEDLINE DCOM- 20251015 LR - 20251015 IS - 1536-7312 (Electronic) IS - 0196-206X (Linking) VI - 46 IP - 5 DP - 2025 Sep-Oct 01 TI - Precision Medicine in Pediatric Attention-deficit/Hyperactivity Disorder: A Systematic Review of Behavioral, Neurobiological and Genetic Diagnostic Biomarkers. PG - e481-e498 LID - 10.1097/DBP.0000000000001403 [doi] AB - OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) is one of the most common childhood psychiatric disorders and a common presenting concern in primary and developmental pediatric care. However, objective diagnostic tools are currently not available, leading to delayed and missed diagnoses. The current systematic review aimed to determine whether objective indices can serve as diagnostic markers for pediatric ADHD. METHOD: We conducted a systematic review of objective behavioral, neurobiological, and genetic biomarkers that could inform a precision medicine approach to diagnosis of pediatric ADHD. Following the PRISMA guidelines, we searched three major databases (MEDLINE, PsycInfo, and Scopus) for articles published between 2012 and 2024 that evaluated diagnostic biomarkers with a translational aim. RESULTS: A total of 111 studies met inclusion criteria, including 42 behavioral, 44 neuroimaging, and 25 genetic studies. Among behavioral studies, measures of physical activity achieved discriminant validity in the good to excellent range. Neuroimaging biomarkers were strongest when machine learning and multiple-features models were used. A particularly promising direction involved task-based NIRS paradigms targeting cognitive control. The results of the genetic studies underscored the complexity of the genetic architecture of ADHD, implicating rare and common variants, as well as epigenetic mechanisms. MicroRNA and methylation profiles demonstrated the strongest accuracy, overall. CONCLUSION: Our systematic review identified promising candidate diagnostic markers for ADHD across behavioral, neuroimaging, and genetic methods. Multimethod approaches are likely to yield the strongest diagnostic accuracy. The complexity and cost of these approaches limits potential for implementation of a precision medicine approach to pediatric ADHD diagnosis in primary care settings. CI - Copyright (c) 2025 Wolters Kluwer Health, Inc. All rights reserved. FAU - Pranjic, Marija AU - Pranjic M AD - Division of Developmental Medicine, Boston Children's Hospital, Boston, MA; and. AD - Pediatrics, Harvard Medical School, Boston, MA. FAU - Peisch, Virginia AU - Peisch V AD - Division of Developmental Medicine, Boston Children's Hospital, Boston, MA; and. FAU - Vuksic, Nikolina AU - Vuksic N AD - Division of Developmental Medicine, Boston Children's Hospital, Boston, MA; and. FAU - Subedi, Sambridhi AU - Subedi S AD - Division of Developmental Medicine, Boston Children's Hospital, Boston, MA; and. FAU - Arnett, Anne B AU - Arnett AB AD - Division of Developmental Medicine, Boston Children's Hospital, Boston, MA; and. AD - Pediatrics, Harvard Medical School, Boston, MA. LA - eng PT - Journal Article PT - Systematic Review DEP - 20250905 PL - United States TA - J Dev Behav Pediatr JT - Journal of developmental and behavioral pediatrics : JDBP JID - 8006933 RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Attention Deficit Disorder with Hyperactivity/diagnosis/genetics/physiopathology MH - *Precision Medicine/methods MH - Child MH - Biomarkers MH - Neuroimaging OTO - NOTNLM OT - attention-deficit/hyperactivity disorder OT - biomarkers OT - diagnostic accuracy OT - pediatric OT - precision medicine COIS- The authors declare no conflict of interest. EDAT- 2025/09/05 12:40 MHDA- 2025/10/15 12:31 CRDT- 2025/09/05 09:43 PHST- 2024/12/13 00:00 [received] PHST- 2025/06/27 00:00 [accepted] PHST- 2025/10/15 12:31 [medline] PHST- 2025/09/05 12:40 [pubmed] PHST- 2025/09/05 09:43 [entrez] AID - 00004703-990000000-00300 [pii] AID - 10.1097/DBP.0000000000001403 [doi] PST - ppublish SO - J Dev Behav Pediatr. 2025 Sep-Oct 01;46(5):e481-e498. doi: 10.1097/DBP.0000000000001403. Epub 2025 Sep 5. PMID- 40910033 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250915 LR - 20250915 IS - 1939-795X (Print) IS - 1939-795X (Electronic) IS - 1939-795X (Linking) VI - 18 IP - 2 DP - 2025 TI - Validity and Reliability of the 'Feelfit(R)' Accelerometer in Evaluating Physical Activity and Sedentary Time in Children: A Comparative Study with Two Different Accelerometers. PG - 794-810 LID - 10.70252/NOCK5583 [doi] AB - Accurate physical activity (PA) measurement is crucial for public health surveillance. While self-report questionnaires are commonly used, they have limitations, especially in young children. An affordable and user-friendly device like Feelfit(R) offers a promising alternative particularly for countries with limited research resources. This study aimed to evaluate Feelfit(R)'s performance against the widely used ActiGraph(R) accelerometer in measuring PA among children. A quasi-experimental design was applied. Thirty-nine children (19 boys; 20 girls; aged 11.4 +/- 0.5 years) wore both Feelfit(R) and ActiGraph(R) during sequentially specified activities of varying intensity ranging from sedentary to vigorous. Data were analysed using paired t-tests, Bland-Altman plots, and intra-class correlation coefficients (ICCs) to assess agreement, precision, and reliability. Feelfit(R) showed good agreement with ActiGraph(R) for moderate-to-vigorous PA (MVPA) but overestimated sedentary time and underestimated light PA. It demonstrated better precision for MVPA but low reliability for light PA. Intra-class correlation coefficients were moderate for MVPA (ICC = 0.43), but poor for sedentary time (ICC = 0.11). Feelfit(R) is a suitable option for measuring MVPA in children, offering acceptable validity and reliability compared to ActiGraph(R). However, improvements are needed for accurate measure of sedentary and light activities. Despite these limitations, Feelfit(R)'s affordability and ease of use make it a valuable tool for use in small- to large-scale research and in resource-limited settings. FAU - Chinapong, Songdhasn AU - Chinapong S AD - Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand. FAU - Klinchan, Korntawat AU - Klinchan K AD - College of Sports Science and Technology, Mahidol University, Nakhon Pathom, Thailand. FAU - Rahman, Hanif Abdul AU - Rahman HA AD - PAPRSB Institute of Health Sciences and School of Digital Science, Universiti Brunei Darussalam, Gadong, Brunei Darussalam. FAU - Chia, Michael AU - Chia M AD - Physical Education & Sports Science Department, National Institute of Education, Nanyang Technological University, Singapore. FAU - Wongpipit, Waris AU - Wongpipit W AD - Division of Health and Physical Education, Faculty of Education, Chulalongkorn University, Bangkok, Thailand. AD - Research Unit for Sports Management & Physical Activity Policy (RU-SMPAP), Chulalongkorn University, Bangkok, Thailand. FAU - Arnin, Jetsada AU - Arnin J AD - Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Nakhon Pathom, Thailand. FAU - Amornsriwatanakul, Areekul AU - Amornsriwatanakul A AD - College of Sports Science and Technology, Mahidol University, Nakhon Pathom, Thailand. LA - eng PT - Journal Article DEP - 20250901 PL - United States TA - Int J Exerc Sci JT - International journal of exercise science JID - 101513127 PMC - PMC12408083 OTO - NOTNLM OT - Measurement accuracy OT - children OT - physical activity OT - public health surveillance OT - research resources EDAT- 2025/09/05 06:35 MHDA- 2025/09/05 06:36 PMCR- 2025/09/01 CRDT- 2025/09/05 05:13 PHST- 2025/09/05 06:36 [medline] PHST- 2025/09/05 06:35 [pubmed] PHST- 2025/09/05 05:13 [entrez] PHST- 2025/09/01 00:00 [pmc-release] AID - ijes-25-18-2-794 [pii] AID - 10.70252/NOCK5583 [doi] PST - epublish SO - Int J Exerc Sci. 2025 Sep 1;18(2):794-810. doi: 10.70252/NOCK5583. eCollection 2025. PMID- 40908657 OWN - NLM STAT- MEDLINE DCOM- 20250905 LR - 20260529 IS - 1520-6300 (Electronic) IS - 1042-0533 (Linking) VI - 37 IP - 9 DP - 2025 Sep TI - Exploring Risk Factors and Predictive Modeling of Child Malnutrition in Pakistan Using Machine Learning. PG - e70124 LID - 10.1002/ajhb.70124 [doi] AB - OBJECTIVE: This study aims to identify risk factors and develop predictive models of child malnutrition (stunting, wasting, and underweight) in Pakistani children under five using machine learning approaches. STUDY DESIGN: This cross-sectional design utilized data from the Pakistan Demographic and Health Survey 2017-2018 (PDHS). METHODS: Logistic regression was employed to identify significant socio-demographic and health-related risk factors. Four machine learning models-Random Forest (RF), Support Vector Machine (SVM), Naive Bayes (NB), and AdaBoost-were applied to predict malnutrition indicators, with performance evaluated based on accuracy, sensitivity, specificity, and F-measure using a two-stage validation strategy (10-fold cross-validation and 80:20 train-test split). RESULTS: Key risk factors identified included consanguineous marriages, lower wealth status, low maternal education, and geographic disparities in Sindh and Baluchistan. Among the machine learning models, Random Forest demonstrated the highest overall accuracy and specificity across all indicators, while SVM showed higher sensitivity for wasted and underweight children. CONCLUSION: The study highlights the complex interplay of socio-demographic factors in child malnutrition and the potential of machine learning models to effectively predict these conditions, underscoring the need for targeted interventions focusing on maternal education, access to clean water and sanitation, and poverty alleviation, particularly in high-risk regions. CI - (c) 2025 Wiley Periodicals LLC. FAU - Saleem, Muhammad Usman AU - Saleem MU AUID- ORCID: 0009-0002-9480-2399 AD - School of Public Policy and Administration, Xi'an Jiaotong University, Xi'an, China. FAU - Aslam, Muhammad Usman AU - Aslam MU AUID- ORCID: 0000-0002-3812-272X AD - School of Mathematics and Statistics, Xi'an Jiaotong University, Xi'an, China. FAU - Khatir, Abdul Ghani AU - Khatir AG AD - School of Public Policy and Administration, Xi'an Jiaotong University, Xi'an, China. FAU - Jiang, Quanbao AU - Jiang Q AD - School of Labor Economics Capital University of Economics and Business, Xian, China. LA - eng PT - Journal Article PL - United States TA - Am J Hum Biol JT - American journal of human biology : the official journal of the Human Biology Council JID - 8915029 SB - IM MH - Humans MH - Pakistan/epidemiology MH - *Machine Learning MH - Risk Factors MH - Child, Preschool MH - Cross-Sectional Studies MH - Infant MH - *Child Nutrition Disorders/epidemiology/etiology MH - Female MH - Male MH - Infant, Newborn MH - Socioeconomic Factors MH - Thinness/epidemiology OTO - NOTNLM OT - machine learning OT - malnutrition OT - stunting OT - underweight OT - wasting EDAT- 2025/09/05 06:35 MHDA- 2025/09/05 06:36 CRDT- 2025/09/05 01:53 PHST- 2025/08/02 00:00 [revised] PHST- 2025/04/11 00:00 [received] PHST- 2025/08/05 00:00 [accepted] PHST- 2025/09/05 06:36 [medline] PHST- 2025/09/05 06:35 [pubmed] PHST- 2025/09/05 01:53 [entrez] AID - 10.1002/ajhb.70124 [doi] PST - ppublish SO - Am J Hum Biol. 2025 Sep;37(9):e70124. doi: 10.1002/ajhb.70124. PMID- 40908318 OWN - NLM STAT- MEDLINE DCOM- 20251216 LR - 20260509 IS - 1432-5241 (Electronic) IS - 0364-216X (Print) IS - 0364-216X (Linking) VI - 49 IP - 21 DP - 2025 Nov TI - Objective Severity Classification of Unilateral Cleft Lip Nasal Deformity Using Nostril Width, Alar Facial Symmetry Ratio, and Columellar Angle to Justify Surgical Outcomes. PG - 5931-5948 LID - 10.1007/s00266-025-05082-6 [doi] AB - INTRODUCTION: Unilateral cleft lip nasal (UCL/N) deformity severity presents complex anatomical challenges, with surgical outcomes influenced by preoperative status. Existing classification systems for UCL/N lack standardization, relying on subjective clinical assessments or isolated anthropometric measures that fails to assess anatomical deformity comprehensively. This limits their utility in objectively stratifying deformity severity and justifying postoperative outcomes. To address this gap, we developed UCL/N Deformity Rating Scale (DRS), an objective classification tool incorporating three validated anatomical indicators: alar facial symmetry ratio, nostril width ratio, and columellar angle. This study aims to (1) validate the scale's reliability for grading preoperative anatomical severity and (2) establish its clinical applicability by correlating preoperative grades with postoperative aesthetic outcomes, thereby justifying surgical outcomes, not evaluating institutional surgical performance. METHODS: This retrospective cohort study (Level III evidence) analyzed standardized, ethically approved two-dimensional photographs from 50 UCL/N pre- and postoperative patients. All photographs were deidentified, randomized, and independently assessed by three consultant plastic surgeons and three trainees to evaluate interrater reliability using the intraclass correlation coefficient (ICC). The DRS was applied to grade pre- and postoperative severity, and 12 paired cases were analyzed to correlate these grades with postoperative aesthetic outcomes, demonstrating the justification system's clinical applicability. RESULTS: Assessments of key anatomical indicators showed consistent agreement across pre- and postoperative evaluations, with no significant differences (p > 0.05). The UCL/N DRS demonstrated good interrater reliability (ICC = 0.64-0.72). In 12 cases, outcomes matched or surpassed predictions: 5 matched, 7 exceeded, and none were substandard. This demonstrates the system's clinical applicability as a standardized tool to grade primary deformity severity and justify surgical outcomes by linking preoperative severity to postoperative results. CONCLUSIONS: Strong interrater reliability across assessors support the UCL/N DRS as a reliable objective tool for assessing the UCL/N anatomical severity and justifying the post-operative outcome. LEVEL OF EVIDENCE III: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . CI - (c) 2025. The Author(s). FAU - Yap, Pauline AU - Yap P AUID- ORCID: 0000-0002-2228-3473 AD - Department of Surgery, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400, Serdang, Selangor, Malaysia. paulineyap@upm.edu.my. FAU - Prasetyono, Theddeus Octavianus Hari AU - Prasetyono TOH AUID- ORCID: 0000-0003-3675-4309 AD - Division of Plastic Surgery, Department of Surgery, Cipto Mangunkusumo Hospital/Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. AD - ICTEC (Indonesian Clinical Training and Education Center), Cipto Mangunkusumo Hospital/Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. FAU - Sulaiman, Wan Azman Wan AU - Sulaiman WAW AUID- ORCID: 0000-0002-0600-9765 AD - Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kota Bharu, Kelantan, Malaysia. AD - Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kota Bharu, Kelantan, Malaysia. FAU - Shah, Nurul Syazana Mohamad AU - Shah NSM AUID- ORCID: 0000-0001-6731-9962 AD - Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kota Bharu, Kelantan, Malaysia. AD - Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kota Bharu, Kelantan, Malaysia. FAU - Johar, Siti Fatimah Noor Mat AU - Johar SFNM AUID- ORCID: 0000-0003-4120-4918 AD - Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kota Bharu, Kelantan, Malaysia. AD - Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kota Bharu, Kelantan, Malaysia. FAU - Basiron, Normala AU - Basiron N AUID- ORCID: 0000-0001-7655-1093 AD - Plastic & Reconstructive Surgery Department, Hospital Kuala Lumpur, 50586, Kuala Lumpur, Malaysia. AD - Department of Surgery, Pusat Perubatan Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. FAU - Rashid, Shawaltul Akhma Harun Nor AU - Rashid SAHN AUID- ORCID: 0000-0002-7335-2942 AD - Plastic Surgery Unit, Department of Surgery, Hospital Taiping, Perak, Malaysia. FAU - Halim, Ahmad Sukari AU - Halim AS AUID- ORCID: 0000-0001-8999-6403 AD - Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kota Bharu, Kelantan, Malaysia. AD - Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kota Bharu, Kelantan, Malaysia. FAU - Lian, Ho Hui AU - Lian HH AD - Faculty of Medicine and Health Sciences (FMHS), Plastic, Aesthetic and Reconstructive Surgery Unit, Universiti Malaysia Sabah, 88400, Kota Kinabalu, Sabah, Malaysia. LA - eng PT - Journal Article DEP - 20250904 PL - United States TA - Aesthetic Plast Surg JT - Aesthetic plastic surgery JID - 7701756 SB - IM MH - Humans MH - *Cleft Lip/surgery/classification/diagnosis MH - Retrospective Studies MH - Female MH - Male MH - *Rhinoplasty/methods MH - Severity of Illness Index MH - *Nose/surgery/abnormalities MH - Reproducibility of Results MH - Treatment Outcome MH - Esthetics MH - Cohort Studies MH - Child MH - Photography MH - Facial Asymmetry/surgery PMC - PMC12705721 OTO - NOTNLM OT - Anthropometry OT - Cleft lip OT - Congenital OT - Nasal deformities OT - Severity classification of unilateral cleft lip and palate OT - Surgical outcome assessment COIS- Declarations. Conflict of interest: The authors declare that they have no conflict of interest. Ethical Approval: This study has obtained Ethical Approval from Jawatankuasa Etika Penyelidikan Manusia Universiti Sains Malaysia (JEPeM-USM) on 29th November 2020. JEPeM Code : USM/JEPeM/20060316. Human and animal rights: Human and animal rights article does not contain any studies with human participants or animals performed by any of the authors. Informed consent: Informed consent to the publication of personal data of the patient has been obtained. EDAT- 2025/09/05 00:35 MHDA- 2025/12/16 06:28 PMCR- 2025/09/04 CRDT- 2025/09/04 23:16 PHST- 2024/10/02 00:00 [received] PHST- 2025/06/23 00:00 [accepted] PHST- 2025/12/16 06:28 [medline] PHST- 2025/09/05 00:35 [pubmed] PHST- 2025/09/04 23:16 [entrez] PHST- 2025/09/04 00:00 [pmc-release] AID - 10.1007/s00266-025-05082-6 [pii] AID - 5082 [pii] AID - 10.1007/s00266-025-05082-6 [doi] PST - ppublish SO - Aesthetic Plast Surg. 2025 Nov;49(21):5931-5948. doi: 10.1007/s00266-025-05082-6. Epub 2025 Sep 4. PMID- 40906705 OWN - NLM STAT- MEDLINE DCOM- 20250904 LR - 20260930 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 9 DP - 2025 TI - The association between adolescents' independent food purchasing and dietary quality differs by socioeconomic status: Findings from a pilot study. PG - e0312903 LID - 10.1371/journal.pone.0312903 [doi] LID - e0312903 AB - During adolescence, many young people start to make more independent food purchases. Subsequently, these independent food choices will increasingly contribute to their overall diet quality; little is known, however, about this relationship. This pilot study aimed to examine the role adolescents' independent food purchases play in their diet quality and assess if these relationships vary according to socio-economic status. A convenience sample of adolescents aged 11-18 years and attending secondary school or college in Hampshire, England, were recruited to participate in a one-week cross-sectional observational study. A validated 20-item Food Frequency Questionnaire assessed diet quality. Participants used an ecological momentary assessment mobile phone app to record food purchases. Over seven days, 552 food/drink items were purchased on 253 food purchasing occasions by 80 participants. The majority of purchases (n = 329, 59%) were coded as 'not adhering' to the UK Eatwell Guide, 32% were coded as 'adhering' and 9% fell between these categories being coded as 'combination'. The healthfulness of food purchases did not differ between adolescents from low- and high-SES households. Across all adolescents, 39% reported that their food and drink purchases were snacks and these were less healthful than purchases made for main meals. Fully adjusted regression models showed that adolescents who made less healthy food purchases tended to have poorer quality diets (beta 0.36, (95%CI -0.15, 0.87) p = 0.16). Interaction models showed that less healthy purchasing was more strongly associated with poorer diet quality among young people of lower SES than those of higher SES (p = 0.01). Future research should focus on identifying ways to support more healthful independent food choices by adolescents to reduce dietary inequalities and improve health and well-being among the next generation of adults. CI - Copyright: (c) 2025 Shaw et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Shaw, Sarah AU - Shaw S AUID- ORCID: 0000-0002-2206-6858 AD - MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, United Kingdom. AD - NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom. FAU - Crozier, Sarah AU - Crozier S AD - MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, United Kingdom. AD - NIHR Applied Research Collaboration Wessex, Southampton Science Park, Innovation Centre, Southampton, United Kingdom. FAU - Cooper, Cyrus AU - Cooper C AD - MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, United Kingdom. AD - NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom. FAU - Smith, Dianna AU - Smith D AD - NIHR Applied Research Collaboration Wessex, Southampton Science Park, Innovation Centre, Southampton, United Kingdom. AD - Geography and Environmental Science, University of Southampton, Southampton, United Kingdom. FAU - Barker, Mary AU - Barker M AD - MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, United Kingdom. AD - NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom. AD - School of Health Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, United Kingdom. FAU - Vogel, Christina AU - Vogel C AD - MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, United Kingdom. AD - NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom. AD - NIHR Applied Research Collaboration Wessex, Southampton Science Park, Innovation Centre, Southampton, United Kingdom. AD - Centre for Food Policy, City St Georges, University of London, London, United Kingdom. LA - eng PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20250904 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - Pilot Projects MH - Child MH - Cross-Sectional Studies MH - *Food Preferences MH - *Social Class MH - *Diet MH - *Consumer Behavior MH - England MH - Choice Behavior PMC - PMC12410734 COIS- SS, SC, CC, DS, MB have no conflicts of interests to declare. CV has a non-financial research collaboration with a UK supermarket chain. The study described in this manuscript is not related to this relationship. This does not alter our adherence to PLOS ONE policies on sharing data and materials. EDAT- 2025/09/04 18:34 MHDA- 2025/09/04 18:35 PMCR- 2025/09/04 CRDT- 2025/09/04 13:42 PHST- 2024/10/15 00:00 [received] PHST- 2025/07/23 00:00 [accepted] PHST- 2025/09/04 18:35 [medline] PHST- 2025/09/04 18:34 [pubmed] PHST- 2025/09/04 13:42 [entrez] PHST- 2025/09/04 00:00 [pmc-release] AID - PONE-D-24-45297 [pii] AID - 10.1371/journal.pone.0312903 [doi] PST - epublish SO - PLoS One. 2025 Sep 4;20(9):e0312903. doi: 10.1371/journal.pone.0312903. eCollection 2025. PMID- 40905732 OWN - NLM STAT- MEDLINE DCOM- 20260109 LR - 20260109 IS - 1878-6324 (Electronic) IS - 1053-8127 (Linking) VI - 39 IP - 1 DP - 2026 Jan TI - Normative values and phenotypic performance profiles in the modified closed kinetic chain upper extremity stability test among healthy indian adults- A cross-sectional study. PG - 332-339 LID - 10.1177/10538127251371534 [doi] AB - BackgroundThe closed kinetic chain upper extremity stability test (CKCUEST) is widely used to assess shoulder stability. The modified CKCUEST (mCKCUEST) incorporates height-normalized hand spacing (50%) to account for individual anthropometric variations and improve biomechanical validity.ObjectiveTo establish normative reference values for mCKCUEST performance in healthy Indian adults and to define diagnostic thresholds and performance phenotypes using percentile classification, ROC analysis, and clustering techniques.MethodsA cross-sectional study was conducted among 517 physically active participants (53.6% females) aged 18-28 years. Each participant completed three mCKCUEST trials. Mean, relative (touches/meter), and power scores were calculated. Percentile ranks were stratified by sex. ROC analysis assessed discriminatory cut-offs, while k-means clustering was used to identify phenotypic subgroups. An adaptation index (Trial 3-Trial 1) was computed to evaluate neuromuscular responsiveness.ResultsThe mean mCKCUEST score was 17.6 +/- 2.3 repetitions with a relative score of 10.5 +/- 1.5 touches/meter and a power score of 56.2 +/- 11.9. Males performed better than females in Trials 2 and 3 (p < 0.001). No significant correlations were observed between anthropometric variables and performance outcomes. K-means clustering revealed three distinct performance phenotypes, including one with low baseline scores but high neuromuscular adaptability. BMI-based stratification showed most participants were in the normal range (72.5%).ConclusionThis study provides normative benchmarks for mCKCUEST in healthy Indian adults. The integration of percentile norms, BMI stratification, and adaptation-based phenotypes enhances individualized interpretation in clinical and performance assessment settings. FAU - Rajasekhar, Akshitha AU - Rajasekhar A AD - Institute of Physiotherapy, Srinivas University City campus Pandeshwar, Mangaluru, Karnataka, India. FAU - Kousar, Rifna AU - Kousar R AUID- ORCID: 0009-0004-0016-7078 AD - Institute of Physiotherapy, Srinivas University City campus Pandeshwar, Mangaluru, Karnataka, India. FAU - Ramadevarapura Honnahalagegowda, Ravi AU - Ramadevarapura Honnahalagegowda R AUID- ORCID: 0009-0004-1683-8606 AD - Institute of Physiotherapy, Srinivas University City campus Pandeshwar, Mangaluru, Karnataka, India. FAU - Raveendran, Remya AU - Raveendran R AD - Institute of Physiotherapy, Srinivas University City campus Pandeshwar, Mangaluru, Karnataka, India. FAU - Palaniswamy, Vijayakumar AU - Palaniswamy V AUID- ORCID: 0009-0002-0628-5505 AD - Institute of Physiotherapy, Srinivas University City campus Pandeshwar, Mangaluru, Karnataka, India. LA - eng PT - Journal Article DEP - 20250904 PL - United States TA - J Back Musculoskelet Rehabil JT - Journal of back and musculoskeletal rehabilitation JID - 9201340 SB - IM MH - Humans MH - Male MH - Female MH - Cross-Sectional Studies MH - Adult MH - Young Adult MH - India MH - Reference Values MH - Adolescent MH - *Upper Extremity/physiology MH - Phenotype MH - Healthy Volunteers MH - *Shoulder/physiology OTO - NOTNLM OT - BMI OT - India OT - cluster analysis OT - motor skills OT - muscle strength OT - phenotype OT - reference values OT - upper extremity COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Data availability interestsData sheets and Supplementary Information are available at: EDAT- 2025/09/04 12:37 MHDA- 2026/01/09 13:33 CRDT- 2025/09/04 09:24 PHST- 2026/01/09 13:33 [medline] PHST- 2025/09/04 12:37 [pubmed] PHST- 2025/09/04 09:24 [entrez] AID - 10.1177/10538127251371534 [doi] PST - ppublish SO - J Back Musculoskelet Rehabil. 2026 Jan;39(1):332-339. doi: 10.1177/10538127251371534. Epub 2025 Sep 4. PMID- 40905704 OWN - NLM STAT- MEDLINE DCOM- 20260406 LR - 20260406 IS - 1536-0210 (Electronic) IS - 0020-9996 (Linking) VI - 61 IP - 5 DP - 2026 May 1 TI - Photon-counting Detector CT Enables Pediatric Low-dose Chest Imaging With Further Reduction of Radiation Exposure. PG - 318-325 LID - 10.1097/RLI.0000000000001234 [doi] AB - BACKGROUND: Photon-counting detector computed tomography (PCD CT) offers higher dose efficiency than conventional energy-integrating detector CT (EID CT), which is particularly beneficial for children. Broad evidence is missing whether frequently acquired pediatric low-dose lung imaging can be further improved using PCD CT. OBJECTIVE: To compare radiation exposure, quantitative and qualitative image quality of pediatric low-dose chest PCD CT versus EID CT examinations. METHODS: Unenhanced low-dose chest PCD CT and EID CT examinations acquired for clinical indications were retrospectively compared. Cohorts were matched by water-equivalent diameter (D w ) and age (n=44 each; median age 6.3 y PCD CT vs. 7.4 y EID CT). Radiation exposure was analyzed by volume CT dose index (CTDI vol ), dose length product (DLP), and size-specific dose estimate (SSDE). Quantitative image quality assessment featured the placement of regions of interest (ROIs) in the lung, heart, and liver for the extraction of mean attenuation, noise, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and figures of merit (FOMs). Qualitative image quality was evaluated by 3 readers using Likert scales and additional direct comparisons in a blinded manner. RESULTS: Weight, height, and body mass index (BMI) were not significantly different between the 2 cohorts ( P >0.05). PCD CT examinations showed lower median CTDI vol (0.27 vs. 0.39 mGy, P <0.0001), DLP (6.71 vs. 8.75 mGy*cm, P <0.0001), and SSDE (0.55 vs. 0.83 mGy, P <0.0001) compared with EID CT. Mean attenuation [-797.76 vs. -772.50 Hounsfield units (HU), P =0.51], noise (17.82 vs. 17.69 HU, P =0.73), SNR (-46.10 vs. -45.40, P =0.63), and CNR (39.26 vs. 39.76, P =0.68) of lung parenchyma were not significantly different; respective dose efficiency expressed by FOM was higher in PCD CT compared with EID CT (mean 8030 vs. 5482 mGy -1 , P <0.0001). Qualitative rating showed equal and overall excellent scores for both cohorts. CONCLUSIONS: PCD CT enables pediatric low-dose chest imaging with lower radiation exposure at similar image quality compared with EID CT. CI - Copyright (c) 2025 Wolters Kluwer Health, Inc. All rights reserved. FAU - Krueger, Markus Benedikt AU - Krueger MB AUID- ORCID: 0009-0001-1971-2265 FAU - Werncke, Thomas AU - Werncke T FAU - Eicke, Marcel AU - Eicke M FAU - Schwerk, Nicolaus AU - Schwerk N FAU - Eckstein, Jan AU - Eckstein J FAU - Huisinga, Carolin AU - Huisinga C FAU - Panknin, Christoph AU - Panknin C FAU - Shin, Hoen-Oh AU - Shin HO FAU - Silchmuller, Farina Josepha AU - Silchmuller FJ FAU - Schultze-Florey, Rebecca Elisabeth AU - Schultze-Florey RE FAU - Hansen, Gesine AU - Hansen G FAU - Wacker, Frank AU - Wacker F FAU - Hellms, Susanne AU - Hellms S FAU - Renz, Diane Miriam AU - Renz DM LA - eng PT - Journal Article DEP - 20260501 PL - United States TA - Invest Radiol JT - Investigative radiology JID - 0045377 SB - IM MH - Humans MH - *Tomography, X-Ray Computed/methods/instrumentation MH - Child MH - Female MH - Radiation Dosage MH - Male MH - *Radiography, Thoracic/methods/instrumentation MH - Child, Preschool MH - *Radiation Exposure/prevention & control/analysis MH - Retrospective Studies MH - Photons MH - *Radiation Protection/methods MH - Infant MH - Adolescent MH - Sensitivity and Specificity MH - Reproducibility of Results OTO - NOTNLM OT - dose efficiency OT - image quality OT - pediatric low-dose CT OT - photon-counting OT - radiation exposure COIS- Conflicts of interest and source of funding: The study was initiated, designed, and evaluated by the authors, independent from any funding. The study was funded by Siemens Healthineers and by the Radiological Cooperative Network (RACOON) of the Network University Medicine (NUM) under the BMBF grant numbers 01KX2021 and 01KX2121. EDAT- 2025/09/04 12:37 MHDA- 2026/04/06 12:36 CRDT- 2025/09/04 09:12 PHST- 2025/05/08 00:00 [received] PHST- 2025/07/05 00:00 [accepted] PHST- 2026/04/06 12:36 [medline] PHST- 2025/09/04 12:37 [pubmed] PHST- 2025/09/04 09:12 [entrez] AID - 00004424-202605000-00004 [pii] AID - 10.1097/RLI.0000000000001234 [doi] PST - epublish SO - Invest Radiol. 2026 May 1;61(5):318-325. doi: 10.1097/RLI.0000000000001234. PMID- 40904215 OWN - NLM STAT- MEDLINE DCOM- 20260327 LR - 20261002 IS - 1746-1561 (Electronic) IS - 0022-4391 (Print) IS - 0022-4391 (Linking) VI - 95 IP - 12 DP - 2025 Dec TI - A Novel Survey for Assessing Health-Promoting School Practices and Capacity: Validation and Adaptability to Physical Activity. PG - 1047-1059 LID - 10.1111/josh.70071 [doi] AB - BACKGROUND: Understanding current practice is crucial for implementing Health Promoting Schools (HPS) and Whole School Approaches to Physical Activity (WSA-PA). This study validated two survey tools to assess HPS and WSA-PA implementation, respectively. METHODS: Content validity was established via literature review and expert and target group consultations. Teachers at Danish schools for vulnerable youth (ages 16-25) completed surveys in fall 2023. Structural validity was assessed using confirmatory factor analysis, construct validity via the Multitrait-Multimethod (MTMM) approach, and reliability with Cronbach's Alpha, Omega H, and Intraclass Correlation Coefficient. RESULTS: A total of 921 staff at 78 schools participated (72% response rate). The HPS scale had 24 items, while the WSA-PA had 21 across various subfactors, such as school ethos, health services, and resources. Statistical analyses demonstrated good structural validity (e.g., RMSEA = 0.023 for HPS, RMSEA = 0.043 for WSA-PA) and acceptable reliability. MTMM confirmed both convergent and discriminant validity. IMPLICATIONS FOR SCHOOL HEALTH POLICY, PRACTICE, AND EQUITY: These tools can help schools monitor and improve HPS and WSA-PA implementation, supporting equity and informing national policies. CONCLUSION: The validated tools can guide schools in enhancing HPS and WSA-PA practices. Further research should refine these instruments. CI - (c) 2025 The Author(s). Journal of School Health published by Wiley Periodicals LLC on behalf of American School Health Association. FAU - Hjort, Anneke Vang AU - Hjort AV AUID- ORCID: 0000-0001-6710-411X AD - Centre for Childhood Health, Copenhagen, Denmark. AD - Systems Approaches in Public Health, Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Herlev, Denmark. FAU - Bauman, Adrian AU - Bauman A AUID- ORCID: 0000-0002-0369-4621 AD - School of Public Health, Sydney University, Sydney, Australia. FAU - Carlsen, Sofie Rolff AU - Carlsen SR AUID- ORCID: 0009-0007-9890-3388 AD - Systems Approaches in Public Health, Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Herlev, Denmark. FAU - Lorenzen, Johanne Triantafyllou AU - Lorenzen JT AD - Systems Approaches in Public Health, Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Herlev, Denmark. FAU - Klinker, Charlotte Demant AU - Klinker CD AUID- ORCID: 0000-0002-3252-8366 AD - Systems Approaches in Public Health, Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Herlev, Denmark. LA - eng GR - Hjerteforeningen/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250904 PL - United States TA - J Sch Health JT - The Journal of school health JID - 0376370 SB - IM MH - Reproducibility of Results MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - Adult MH - Schools MH - *School Health Services/organization & administration/standards MH - *Program Evaluation/methods/standards MH - *Health Care Surveys/methods/standards MH - Denmark MH - *Psychometrics/instrumentation PMC - PMC12621173 OTO - NOTNLM OT - health-promoting school OT - implementation assessment OT - measurement tools OT - physical activity OT - survey validation OT - whole school approach COIS- The authors declare no conflicts of interest. EDAT- 2025/09/04 06:37 MHDA- 2025/11/17 09:08 PMCR- 2025/11/17 CRDT- 2025/09/04 03:34 PHST- 2025/06/05 00:00 [revised] PHST- 2025/06/05 00:00 [received] PHST- 2025/08/14 00:00 [accepted] PHST- 2025/11/17 09:08 [medline] PHST- 2025/09/04 06:37 [pubmed] PHST- 2025/09/04 03:34 [entrez] PHST- 2025/11/17 00:00 [pmc-release] AID - JOSH70071 [pii] AID - 10.1111/josh.70071 [doi] PST - ppublish SO - J Sch Health. 2025 Dec;95(12):1047-1059. doi: 10.1111/josh.70071. Epub 2025 Sep 4. PMID- 40903087 OWN - NLM STAT- MEDLINE DCOM- 20250903 LR - 20250906 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 9 DP - 2025 Sep 3 TI - Longitudinal investigation of psychological outcomes associated with screen use in Danish preschool children: study protocol for The Digital Child. PG - e103198 LID - 10.1136/bmjopen-2025-103198 [doi] LID - e103198 AB - INTRODUCTION: Despite an increasing use of screens among preschool children and evidence suggesting potential adverse effects, there is a paucity of longitudinal research that aims to disentangle the multifaceted components of screen use and their unique associations with development. We present a protocol for a large-scale national longitudinal study with repeated measurements in Danish preschool children, with the aim of investigating the cross-sectional and cross-lagged longitudinal associations between screen use and psychological outcomes. METHODS AND ANALYSIS: The Digital Child Study is a national prospective observational cohort of Danish preschool children. Baseline parent-report data collection commenced in 2024 via online questionnaires, and in total will include three time points over 1 year: baseline (age 4 years), and follow-ups at 6 and 12 months (ages 4.5 and 5 years). Participants were divided into two waves based on birth dates, starting in March and September 2024. Recruitment targeted parents and primary caregivers of all Danish children born between specific dates in 2020. Of 30 235 children whose parents were sent invitations, baseline questionnaire data were available for 11 690 (39%).Children's screen use was measured by detailed information of amount, content and timing of children's screen use, and the broader context, incorporating parental mediation strategies, attitudes, motivations and practices. Cognitive and socioemotional developmental outcomes were measured using validated tools such as the Strengths and Difficulties Questionnaire, the Nordic Five-to-Fifteen parent questionnaire and the Behaviour Rating Inventory of Executive Function-Preschool Version. Questionnaire data will be linked to national social and health registries to enable long-term follow-up. Statistical analyses will include longitudinal modelling to explore associations between screen use and developmental outcomes, with sensitivity analyses for robustness. The study's large sample size provides high statistical power to detect meaningful effects. ETHICS AND DISSEMINATION: The study adheres to ethical research guidelines, ensuring voluntary participation, confidentiality and compliance with data protection laws, with approvals from relevant authorities. Findings will be disseminated through peer-reviewed publications, conferences and plain-language summaries to engage stakeholders and the broader community. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Nygaard, Mette AU - Nygaard M AUID- ORCID: 0009-0001-8896-4781 AD - National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. FAU - Olsen, Mille Faurhoj AU - Olsen MF AD - National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. FAU - Thomsen, Melissa M W AU - Thomsen MMW AD - National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. FAU - Hadi, Nur Hazwani Abd AU - Hadi NHA AD - School of Psychology, Deakin University, Geelong, Victoria, Australia. FAU - Trans, Katrine Lynggaard AU - Trans KL AUID- ORCID: 0009-0001-2744-0458 AD - National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. FAU - Horwood, Sharon AU - Horwood S AD - School of Psychology, Deakin University, Geelong, Victoria, Australia. FAU - Flensborg-Madsen, Trine AU - Flensborg-Madsen T AUID- ORCID: 0000-0002-6753-335X AD - National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark tfl@sdu.dk. LA - eng PT - Journal Article DEP - 20250903 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Denmark MH - Child, Preschool MH - Longitudinal Studies MH - *Screen Time MH - Prospective Studies MH - Female MH - Male MH - *Child Development MH - Surveys and Questionnaires MH - Cross-Sectional Studies MH - Parents/psychology MH - Research Design MH - *Child Behavior/psychology PMC - PMC12410681 OTO - NOTNLM OT - Child OT - Cognition OT - Observational Study OT - PUBLIC HEALTH OT - Social Interaction OT - Surveys and Questionnaires COIS- Competing interests: None declared. EDAT- 2025/09/04 00:35 MHDA- 2025/09/04 00:36 PMCR- 2025/09/03 CRDT- 2025/09/03 20:53 PHST- 2025/09/04 00:36 [medline] PHST- 2025/09/04 00:35 [pubmed] PHST- 2025/09/03 20:53 [entrez] PHST- 2025/09/03 00:00 [pmc-release] AID - bmjopen-2025-103198 [pii] AID - 10.1136/bmjopen-2025-103198 [doi] PST - epublish SO - BMJ Open. 2025 Sep 3;15(9):e103198. doi: 10.1136/bmjopen-2025-103198. PMID- 40903016 OWN - NLM STAT- MEDLINE DCOM- 20251216 LR - 20260911 IS - 1530-0315 (Electronic) IS - 0195-9131 (Linking) VI - 58 IP - 1 DP - 2026 Jan 1 TI - Initial Validation of the PATCH: An Open-Source Device Designed to Measure Energy Expenditure among Children Aged 3-8 years. PG - 182-190 LID - 10.1249/MSS.0000000000003841 [doi] AB - BACKGROUND: Wearable devices that measure energy expenditure are not designed for children. Therefore, we developed the PATCH (Platform for Accurate Tracking of Children's Health), an open-source device to measure children's energy expenditure using heart rate (HR) and acceleration. This study examines three models to estimate children's oxygen consumption using HR and acceleration compared with a criterion of indirect calorimetry. METHODS: Fifty-two children aged 3-8 years (mean age, 6.4 +/- 1.7 years; 42% female; 73% White) completed a semistructured protocol ranging in intensity from inactive (e.g., using iPad) to vigorous (e.g., running). The PATCH was attached to the chest and measured HR (photoplethysmography) and acceleration (three-axis accelerometer, +/-16 g). The criterion (Cosmed K5) measured breath-by-breath oxygen uptake (V̇O 2 ; mL.kg -1 .min -1 ). We used cross-sectional time series (CSTS) models, generalized additive mixed models (GAMM), and random forest (RF) to predict oxygen consumption from a combination of HR, acceleration, and participant characteristics (biological sex, age, weight, height). We used 10-fold cross-validation, testing each fold and training on the rest, repeated for robustness. Model fit was assessed using mean bias, mean absolute error, mean absolute percent error, and variance explained ( R2 ). We reported out-of-sample R2 values without subject-specific random effects to ensure broad applicability. RESULTS: Mean bias values for CSTS, GAMM, and RF were -0.01, 0.01, and 0.08 mL.kg -1 .min -1 , respectively. Mean absolute error values were 1.54, 1.56, and 1.99 mL.kg -1 .min -1 ; mean absolute percent error was 10% for CSTS and GAMM, and 13% for RF. The CSTS explained 86% (SD, 5%) of variance, GAMM explained 86% (SD, 5%), and RF explained 81% (SD, 6%) in oxygen consumption. CONCLUSIONS: CSTS, GAMM, and RF models provide similarly accurate estimates of children's oxygen consumption using the PATCH device compared with indirect calorimetry. Further validation in larger, free-living samples is needed. CI - Copyright (c) 2025 by the American College of Sports Medicine. FAU - Ghosal, Rahul AU - Ghosal R AD - Department Epidemiology and Biostatistics, University of South Carolina, Columbia, SC. FAU - Weaver, R Glenn AU - Weaver RG AD - Department of Exercise Science, University of South Carolina, Columbia, SC. FAU - Parker, Hannah AU - Parker H AD - Department of Exercise Science, University of South Carolina, Columbia, SC. FAU - Burkart, Sarah AU - Burkart S AD - Department of Exercise Science, University of South Carolina, Columbia, SC. FAU - McAninch, Jonas AU - McAninch J AD - University of Michigan School of Kinesiology, Ann Arbor, MI. FAU - Lane, Abbi D AU - Lane AD AD - University of Michigan School of Kinesiology, Ann Arbor, MI. FAU - Smith, Michal T AU - Smith MT AD - Department of Exercise Science, University of South Carolina, Columbia, SC. FAU - Hill, Sydney AU - Hill S AD - Department of Exercise Science, University of South Carolina, Columbia, SC. FAU - Pate, Russell R AU - Pate RR AD - Department of Exercise Science, University of South Carolina, Columbia, SC. FAU - Chandrashekhar, Mvs AU - Chandrashekhar M AD - Department of Electrical and Computer Engineering, Morgan State University, Baltimore, MD. FAU - Armstrong, Bridget AU - Armstrong B AD - Department of Exercise Science, University of South Carolina, Columbia, SC. LA - eng GR - R21 DK131387/DK/NIDDK NIH HHS/United States GR - P20 GM130420/GM/NIGMS NIH HHS/United States GR - R01 HL171295/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Validation Study DEP - 20250903 PL - United States TA - Med Sci Sports Exerc JT - Medicine and science in sports and exercise JID - 8005433 SB - IM MH - Humans MH - Child MH - Female MH - *Energy Metabolism MH - Male MH - Child, Preschool MH - Oxygen Consumption MH - Calorimetry, Indirect MH - Heart Rate MH - Accelerometry/instrumentation MH - Cross-Sectional Studies MH - *Wearable Electronic Devices MH - Acceleration MH - Photoplethysmography OTO - NOTNLM OT - ACCELEROMETERY OT - CHILDREN OT - ENERGY EXPENDITURE OT - HEART RATE OT - INDIRECT CALORIMETRY OT - MEASUREMENT OT - OPEN SOURCE OT - OXYGEN CONSUMPTION OT - WEARABLE TECHNOLOGY EDAT- 2025/09/04 00:35 MHDA- 2025/12/16 06:28 CRDT- 2025/09/03 20:03 PHST- 2025/02/19 00:00 [received] PHST- 2025/08/13 00:00 [accepted] PHST- 2025/12/16 06:28 [medline] PHST- 2025/09/04 00:35 [pubmed] PHST- 2025/09/03 20:03 [entrez] AID - 00005768-990000000-00897 [pii] AID - 10.1249/MSS.0000000000003841 [doi] PST - ppublish SO - Med Sci Sports Exerc. 2026 Jan 1;58(1):182-190. doi: 10.1249/MSS.0000000000003841. Epub 2025 Sep 3. PMID- 40902438 OWN - NLM STAT- MEDLINE DCOM- 20250925 LR - 20250929 IS - 1872-7727 (Electronic) IS - 0720-048X (Linking) VI - 192 DP - 2025 Nov TI - Predictive performance of distinct skeletal muscle index cut-offs-defined sarcopenia for long-term mortality in decompensated cirrhosis: A prospective observational study. PG - 112396 LID - S0720-048X(25)00482-6 [pii] LID - 10.1016/j.ejrad.2025.112396 [doi] AB - PURPOSE: Although the clinical implication of sarcopenia has been verified in the context of cirrhosis, there is limited data concerning cut-offs of CT-measured skeletal muscle index (SMI) across different ethnicities. We aimed to compare the predictive performance of distinct SMI values-defined sarcopenia for prognosis in cirrhosis. METHODS: Totally, 478 inpatients due to cirrhosis-associated acute insults were prospectively enrolled. A range of cut-offs concerning SMI (Tianjin, northernChina, southernChina, Japan and Turkey criteria) were testified to determine 2-year all-cause mortality according to the Kaplan-Meier survival curve and multivariate Cox regression model. RESULTS: Sarcopenia was diagnosed in 24.3 %, 6.3 %, 21.1 %, 29.1 % and 6.5 %, respectively, according to Tianjin, northernChina, southernChina, Japan and Turkey criteria. Survival analysis showed marked differences between patients with and without sarcopenia defined by all aforesaid criteria (log-rank test: P < 0.05). Univariate Cox regression indicated that age, Child-Turcotte-Pugh (CTP) class, Model for End-stage Liver Disease-Sodium (MELD-Na), creatinine, bilirubin, white blood cell count, prothrombin time-international normalized ratio, sodium, albumin, ascites, hepatic encephalopathy, infection and sarcopenia were significantly associated with mortality. Further multivariate model fully adjusting age, BMI and MELD-Na/CTP class revealed that all criteria-defined sarcopenia was independently associated with mortality, except for the Turkey criteria. CONCLUSIONS: Our findings provide supporting evidence to develop continent-based SMI cut-offs in hopes of identifying sarcopenic patients with cirrhosis, taking its impact on mortality and morbidity into consideration. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Sun, Chao AU - Sun C AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China. Electronic address: chaosun@tmu.edu.cn. FAU - Wang, Han AU - Wang H AD - Department of Health Management, Tianjin Hospital, No. 406 Jiefang South Road, Hexi District, Tianjin 300211, China. FAU - Yang, Ziyi AU - Yang Z AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China. FAU - Jiao, Huanli AU - Jiao H AD - Department of Health Management, Tianjin Hospital, No. 406 Jiefang South Road, Hexi District, Tianjin 300211, China. LA - eng PT - Journal Article PT - Observational Study DEP - 20250829 PL - Ireland TA - Eur J Radiol JT - European journal of radiology JID - 8106411 SB - IM MH - Humans MH - *Sarcopenia/diagnostic imaging/mortality MH - Male MH - Female MH - *Liver Cirrhosis/mortality/diagnostic imaging/complications MH - Middle Aged MH - Prospective Studies MH - *Muscle, Skeletal/diagnostic imaging MH - *Tomography, X-Ray Computed/statistics & numerical data MH - Aged MH - Survival Rate MH - Prognosis MH - Risk Factors MH - Reproducibility of Results MH - Sensitivity and Specificity OTO - NOTNLM OT - Cut-offs OT - Liver cirrhosis OT - Mortality OT - Sarcopenia OT - Skeletal muscle index COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/09/04 00:36 MHDA- 2025/09/26 00:30 CRDT- 2025/09/03 18:09 PHST- 2025/02/11 00:00 [received] PHST- 2025/07/19 00:00 [revised] PHST- 2025/08/28 00:00 [accepted] PHST- 2025/09/26 00:30 [medline] PHST- 2025/09/04 00:36 [pubmed] PHST- 2025/09/03 18:09 [entrez] AID - S0720-048X(25)00482-6 [pii] AID - 10.1016/j.ejrad.2025.112396 [doi] PST - ppublish SO - Eur J Radiol. 2025 Nov;192:112396. doi: 10.1016/j.ejrad.2025.112396. Epub 2025 Aug 29. PMID- 40901679 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250915 LR - 20250915 IS - 1178-7007 (Print) IS - 1178-7007 (Electronic) IS - 1178-7007 (Linking) VI - 18 DP - 2025 TI - Effects of Different Exercise Interventions on Health Status in Overweight and Obese Children and Adolescents: A Network Meta-Analysis. PG - 3053-3074 LID - 10.2147/DMSO.S528948 [doi] AB - BACKGROUND: While numerous studies have explored the effectiveness of exercise interventions in improving health outcomes in populations with obesity, comparisons of different exercise modalities remain limited. This study aimed to address this gap through a network meta-analysis (NMA) to evaluate the impact of various exercise modalities on health status in children and adolescents with overweight and obesity. METHODS: Two researchers (XC and KD) systematically searched databases including PubMed, Cochrane Library, Embase and others for randomized controlled trials (RCTs) published up to May 2024. The studies analyzed the effects of exercise interventions on body composition, lipid profiles, glucose metabolism, and cardiorespiratory fitness (CRF) in children and adolescents with overweight and obesity. Study quality was assessed using the Cochrane tools, and the random-effects NMA was conducted within a Bayesian framework. RESULTS: A total of 51 studies with 2263 participants were included, covering four exercise modalities: aerobic exercise (AE), resistance exercise (RE), combined exercise (CE), and high-intensity interval training (HIIT). HIIT was relatively more effective for improving CRF, including oxygen uptake peak (VO(2peak)) [MD = 3.33, 95% CI (2.36, 4.26)] and heart rate (HR) [MD = -8.09, 95% CI (-10.92, -5.37)]. AE demonstrated substantial reductions in weight, body mass index (BMI), and waist circumference (WC). CE may be most effective in reducing body fat percentage (BF%), waist-to-hip ratio (WHR), and improving fat-free mass (FFM), as well as controlling fasting glucose (FG) and insulin resistance. RE showed a significant impact on improving lipid profiles. CONCLUSION: HIIT is the relatively effective modality for enhancing CRF, while AE and CE are notably effective for improving body composition. RE is regarded as a preferable choice for lipid regulation, and CE tends to provide superior outcomes for glucose and insulin control. These findings provide comparative evidence for clinical and policy recommendations, though further high-quality research is needed for validation. CI - (c) 2025 Cai et al. FAU - Cai, Xiaoye AU - Cai X AUID- ORCID: 0000-0002-3262-5692 AD - Shanghai Normal University Tianhua College, Shanghai, People's Republic of China. FAU - Cai, Yujun AU - Cai Y AD - Shanghai University of Sport, Shanghai, People's Republic of China. FAU - Da, Yingjuan AU - Da Y AD - Shanghai Normal University Tianhua College, Shanghai, People's Republic of China. FAU - Wang, Feng AU - Wang F AD - Shanghai Ocean University, Shanghai, People's Republic of China. FAU - Wu, Yu AU - Wu Y AD - Guiyang Preschool Education College, Guizhou, People's Republic of China. FAU - Dong, Kexin AU - Dong K AD - Shanghai Lixin University of Accounting and Finance, Shanghai, People's Republic of China. LA - eng PT - Journal Article DEP - 20250826 PL - New Zealand TA - Diabetes Metab Syndr Obes JT - Diabetes, metabolic syndrome and obesity : targets and therapy JID - 101515585 PMC - PMC12399794 OTO - NOTNLM OT - adolescent and children OT - exercise OT - health status OT - network meta-analysis OT - overweight and obesity COIS- The authors report no conflicts of interest in this work. EDAT- 2025/09/03 18:35 MHDA- 2025/09/03 18:36 PMCR- 2025/08/26 CRDT- 2025/09/03 12:17 PHST- 2025/03/19 00:00 [received] PHST- 2025/08/15 00:00 [accepted] PHST- 2025/09/03 18:36 [medline] PHST- 2025/09/03 18:35 [pubmed] PHST- 2025/09/03 12:17 [entrez] PHST- 2025/08/26 00:00 [pmc-release] AID - 528948 [pii] AID - 10.2147/DMSO.S528948 [doi] PST - epublish SO - Diabetes Metab Syndr Obes. 2025 Aug 26;18:3053-3074. doi: 10.2147/DMSO.S528948. eCollection 2025. PMID- 40898999 OWN - NLM STAT- MEDLINE DCOM- 20260209 LR - 20261019 IS - 1537-6591 (Electronic) IS - 1058-4838 (Print) IS - 1058-4838 (Linking) VI - 82 IP - 1 DP - 2026 Feb 9 TI - Body Mass Index and Incident Tuberculosis in Close Tuberculosis Contacts. PG - e100-e109 LID - 10.1093/cid/ciaf475 [doi] AB - BACKGROUND: Approximately 95% of people infected with Mycobacterium tuberculosis do not progress to tuberculosis (TB) disease. Identifying key determinants of TB progression could focus prevention efforts. METHODS: Contacts of pulmonary TB patients were enrolled in a prospective multi-center cohort study (Regional Prospective Observational Research in Tuberculosis [RePORT]-Brazil) from 2015 to 2019 and followed for 24 months. Empirical review and least absolute shrinkage and selection operator (LASSO) regression, using baseline clinical and laboratory information, were used as dimension reduction techniques to determine factors for inclusion in prediction models. Models were created for: (1) all contacts, (2) contacts interferon-gamma release assay (IGRA)-positive at baseline, and (3) IGRA-positive contacts who did not receive TB preventive therapy (TPT; <30 days isoniazid). Internal validation was performed using bootstrapping. RESULTS: Among 1846 contacts of 619 TB index patients, 25 (1.4%) progressed to TB. No TPT was a risk factor for progression to TB among all contacts (mixed-effects adjusted hazard ratio [aHR] = 16.55, 95% confidence interval [CI]: 2.22-124.45). Internal validation with all contacts yielded an area under the receiver operating characteristic curve of 0.80 (95% CI: .72-.86]. Body mass index (BMI) was inversely associated with increased risk of progressing to active TB among IGRA-positive contacts who did not receive TPT (aHR = 0.89, 95% CI: .80-.99). Interferon-gamma release assay-positive contacts with BMI <25 kg/m2 had a 4.14-fold (95% CI: 1.17-14.67) higher risk of progression to TB than IGRA-positive contacts with BMI >/=25 kg/m2: 8.4% versus 2.1%, respectively. CONCLUSIONS: Body mass index <25 kg/m2, a readily available biomarker, identified IGRA-positive close TB contacts at high risk of progressing to TB disease. Prioritizing this high-risk group for TB preventive therapy could improve TB prevention efforts. BMI <25 kg/m(2), a readily available biomarker, identified IGRA-positive close contacts at high risk for progression to TB in a large observational Brazilian cohort. Prioritizing this high-risk group for TB preventive therapy could significantly improve TB prevention efforts. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of Infectious Diseases Society of America. FAU - Arriaga, Maria B AU - Arriaga MB AUID- ORCID: 0000-0001-6883-8422 AD - Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. AD - Fundacao Jose Silveira, Centro de Pesquisa, Aprendizagem e Inovacao, Salvador, Bahia, Brazil. FAU - Amorim, Gustavo AU - Amorim G AD - Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FAU - Figueiredo, Marina C AU - Figueiredo MC AD - Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. FAU - Staats, Cody AU - Staats C AUID- ORCID: 0009-0002-9044-6382 AD - Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. FAU - Kritski, Afranio L AU - Kritski AL AD - Programa Academico de Tuberculose, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Cordeiro-Santo, Marcelo AU - Cordeiro-Santo M AD - Grupo de Pesquisa em Tuberculose, Fundacao Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, Brazil. AD - Programa de Pos-Graduacao em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil. AD - Facultade de Medicina, Universidade Nilton Lins, Manaus, Brazil. FAU - Rolla, Valeria C AU - Rolla VC AD - Laboratorio de Pesquisa Clinica em Micobacterioses, Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro, Brazil. FAU - Rebeiro, Peter F AU - Rebeiro PF AUID- ORCID: 0000-0003-1951-9104 AD - Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. AD - Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA. AD - Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. FAU - Andrade, Bruno B AU - Andrade BB AUID- ORCID: 0000-0001-6833-3811 AD - Laboratorio de Pesquisa Clinica e Translacional, Instituto Goncalo Moniz, Fundacao Oswaldo Cruz, Salvador, Brazil. AD - Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, Brazil. AD - Curso de Medicina, Escola Bahiana de Medicina e Saude Publica (EBMSP), Salvador, Brazil. AD - Instituto de Pesquisa Clinica e Translacional, Faculdade Zarns, Clariens Educacao, Salvador, Brazil. AD - Curso de Medicina, Universidade Salvador, Salvador, Brazil. FAU - Sterling, Timothy R AU - Sterling TR AUID- ORCID: 0000-0002-4822-6979 AD - Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. CN - RePORT-Brazil consortium LA - eng GR - U01 AI172064/AI/NIAID NIH HHS/United States GR - Secretaria de Ciencia e Tecnologia (SCTIE)/ GR - U01-AI069923/FIOCRUZ/ GR - Tecnologia e Innovacion Tecnologica/ GR - Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/ GR - 25029.000507/2013-07/Ministerio da Saude (MS)/ GR - NIH/ GR - Consejo Nacional de Ciencia/ GR - U01 AI069923/AI/NIAID NIH HHS/United States GR - R01 AI147765/AI/NIAID NIH HHS/United States GR - Departamento de Ciencia e Tecnologia (DECIT)/ PT - Journal Article PT - Multicenter Study PT - Observational Study PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PL - United States TA - Clin Infect Dis JT - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JID - 9203213 SB - IM UOF - medRxiv. 2025 Apr 16:2025.04.15.25325878. doi: 10.1101/2025.04.15.25325878. PMID: 40321261 MH - Humans MH - Male MH - Female MH - Prospective Studies MH - Adult MH - *Body Mass Index MH - Middle Aged MH - Brazil/epidemiology MH - Risk Factors MH - Contact Tracing MH - *Tuberculosis/epidemiology MH - Interferon-gamma Release Tests MH - Incidence MH - Mycobacterium tuberculosis MH - Disease Progression MH - Young Adult MH - *Tuberculosis, Pulmonary/epidemiology MH - Adolescent PMC - PMC13637806 MID - NIHMS2209718 OTO - NOTNLM OT - body mass index OT - close contact OT - interferon gamma release assay OT - prediction model OT - tuberculosis progressor COIS- Potential conflicts of interest. The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. FIR - Araujo-Pereira, Mariana IR - Araujo-Pereira M FIR - Andrade, Alice M S IR - Andrade AMS FIR - Lira, Dayse IR - Lira D FIR - Rocha, Michael S IR - Rocha MS FIR - Nascimento, Vanessa IR - Nascimento V FIR - Brito, Pedro IR - Brito P FIR - Santos, Saulo R N IR - Santos SRN FIR - Ramos, Andre IR - Ramos A FIR - Souza, Alexandra Brito IR - Souza AB FIR - Spener-Gomes, Renata IR - Spener-Gomes R FIR - Aguiar, Amanda Franca IR - Aguiar AF FIR - Costa, Alysson G IR - Costa AG FIR - Silva, Jaquelane IR - Silva J FIR - de Oliveira, Jamile G IR - de Oliveira JG FIR - Benjamin, Aline IR - Benjamin A FIR - Gomes-Silva, Adriano IR - Gomes-Silva A FIR - Sant'Anna, Flavia M IR - Sant'Anna FM FIR - Ignacio, Francine P IR - Ignacio FP FIR - Lourenco, Maria Cristina IR - Lourenco MC FIR - Moreira, Adriana S R IR - Moreira ASR FIR - Turner, Megan IR - Turner M FIR - Cavalcante, Solange IR - Cavalcante S FIR - Durovni, Betina IR - Durovni B EDAT- 2025/09/03 06:37 MHDA- 2026/02/09 06:29 PMCR- 2026/10/05 CRDT- 2025/09/03 04:02 PHST- 2025/02/20 00:00 [received] PHST- 2026/02/09 06:29 [medline] PHST- 2025/09/03 06:37 [pubmed] PHST- 2025/09/03 04:02 [entrez] PHST- 2026/10/05 00:00 [pmc-release] AID - 8246436 [pii] AID - 10.1093/cid/ciaf475 [doi] PST - ppublish SO - Clin Infect Dis. 2026 Feb 9;82(1):e100-e109. doi: 10.1093/cid/ciaf475. PMID- 40898099 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260630 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Sep 2 TI - Dietary behaviours, cooking practices and their associations with body weight status among Malaysians - a nationwide study during COVID-19 pandemic. PG - 3020 LID - 10.1186/s12889-025-23699-9 [doi] LID - 3020 AB - OBJECTIVES: This study builds upon our previous MyNutriLifeCOVID-19 online survey conducted during Malaysia's second national lockdown (MCO 2.0), by exploring a broader range of nutritional and lifestyle behaviours and their association with risks of underweight, overweight and obesity among Malaysian adults. DESIGN: Cross-sectional study. SETTING: The MyNutriLifeCOVID-19 was a nationwide survey conducted in all five regions (Central Zone, Northern Zone, Southern Zone, East-coast Zone and East-Malaysia) in Malaysia. PARTICIPANTS: A total of 1182 Malaysian adults participated in the online survey between March and May 2021. OUTCOME MEASURES: Self-reported body weight status, nutritional and lifestyle behaviours, including dietary practices, physical activity, perceived stress, and sleep quality were ascertained using a validated questionnaire. RESULTS: Approximately one-third of the Malaysian adults (36.8%) were either overweight or obese, with 8.63% underweight. Despite widespread intentions to manage weight, only 30% engaged in regular exercise. Poor sleep and unhealthy dietary behaviours, characterised by high sugar intake and low consumption of fruits and vegetables, were prevalent among the respondents. The hierarchical multinomial regression analysis revealed underweight was attributed to being single, experiencing high stress and insufficient exercise. Conversely, overweight and obesity were linked to being male, older, Malay ethnicity, lunch skipping, poor adherence to healthy eating concept, had disordered eating and frequent consumption of roasted foods. CONCLUSION: The present study revealed significant weight-related challenges faced by Malaysians during the national lockdown. Despite efforts at weight management, insufficient physical activity, poor sleep quality, and unhealthy dietary behaviours persisted. These findings underscore the complex interplay of sociodemographic, lifestyle, and dietary factors in shaping weight outcomes among Malaysian adults, emphasised the importance of addressing sociodemographic, lifestyle, and dietary factors in comprehensive public health strategies, as it highlighted multifaceted risk factors for both underweight and overweight/obesity. There is a need for targeted interventions addressing diverse risk profiles to promote healthier lifestyles and combat the growing burden of obesity-related health issues. The findings of this study offer crucial insights into the enduring consequences of the COVID-19 pandemic on Malaysian health behaviours. As the world grapples with the increasing threat of communicable diseases, understanding the long-term impacts of such events on lifestyle and health outcomes is imperative. Our research underscores the need for comprehensive public health interventions that address not only the immediate health challenges but also the lasting psychological and behavioural effects of crises. By investing in resilient health systems and promoting healthy lifestyles, we can better prepare for future pandemics and mitigate their devastating consequences. FAU - Chin, Yit Siew AU - Chin YS AD - Faculty of Medicine and Health Sciences, Strategic Health & Advanced Prevention for Excess Weight & Obesity (PUTRA-SHAPE), Universiti Putra Malaysia, Serdang, Selangor, 43400, Malaysia. chinys@upm.edu.my. AD - Research Centre of Excellence on Nutrition and Non-communicable Diseases, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, 43400, Malaysia. chinys@upm.edu.my. FAU - Lim, Poh Ying AU - Lim PY AD - Department of Community Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, 43400, Malaysia. FAU - Appukutty, Mahenderan AU - Appukutty M AD - Faculty of Sports Science & Recreation, Universiti Teknologi MARA, Shah Alam, Selangor, 40450, Malaysia. FAU - Md Yusop, Nor Baizura AU - Md Yusop NB AD - Faculty of Medicine and Health Sciences, Strategic Health & Advanced Prevention for Excess Weight & Obesity (PUTRA-SHAPE), Universiti Putra Malaysia, Serdang, Selangor, 43400, Malaysia. FAU - Loganathan, Radhika AU - Loganathan R AD - Nutrition Unit, Division of Product Development and Advisory Services, Malaysian Palm Oil Board, No. 6, Persiaran Institusi, Bandar Baru Bangi, Kajang, Selangor, 43000, Malaysia. FAU - Selvaduray, Kanga Rani AU - Selvaduray KR AD - Nutrition Unit, Division of Product Development and Advisory Services, Malaysian Palm Oil Board, No. 6, Persiaran Institusi, Bandar Baru Bangi, Kajang, Selangor, 43000, Malaysia. FAU - Chan, Yoke Mun AU - Chan YM AD - Research Centre of Excellence on Nutrition and Non-communicable Diseases, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, 43400, Malaysia. cym@upm.edu.my. AD - Department of Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, 43400, Malaysia. cym@upm.edu.my. AD - Promoting Resilience and Innovation in Multidisciplinary Ageing Excellence (PrimAGE), Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, 43400, Malaysia. cym@upm.edu.my. LA - eng PT - Journal Article DEP - 20250902 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - Malaysian people SB - IM MH - Humans MH - Malaysia/epidemiology MH - Male MH - Adult MH - Female MH - Cross-Sectional Studies MH - *COVID-19/epidemiology MH - Middle Aged MH - *Cooking MH - Obesity/epidemiology MH - Overweight/epidemiology MH - *Feeding Behavior MH - *Body Weight MH - *Diet/statistics & numerical data MH - Young Adult MH - Thinness/epidemiology MH - Exercise MH - Pandemics MH - Life Style MH - Surveys and Questionnaires MH - Adolescent MH - Southeast Asian People PMC - PMC12403392 COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki. Ethical approval was obtained from Ethics Committee for Research Involving Human Subjects of Universiti Putra Malaysia, with reference number JKEUPM-2020-163. As the study was conducted online during the COVID-19 pandemic, informed consent was obtained electronically from all participants prior to their participation in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/09/03 00:42 MHDA- 2026/06/27 00:58 PMCR- 2025/09/02 CRDT- 2025/09/02 23:36 PHST- 2025/01/08 00:00 [received] PHST- 2025/06/23 00:00 [accepted] PHST- 2026/06/27 00:58 [medline] PHST- 2025/09/03 00:42 [pubmed] PHST- 2025/09/02 23:36 [entrez] PHST- 2025/09/02 00:00 [pmc-release] AID - 10.1186/s12889-025-23699-9 [pii] AID - 23699 [pii] AID - 10.1186/s12889-025-23699-9 [doi] PST - epublish SO - BMC Public Health. 2025 Sep 2;25(1):3020. doi: 10.1186/s12889-025-23699-9. PMID- 40894266 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250905 IS - 2674-0311 (Electronic) IS - 2674-0311 (Linking) VI - 4 IP - 2 DP - 2025 Jun TI - Infant Feeding Practices and Their Association with Early-Life Nutrient Intake: Baseline Findings from the Baby-Act Trial. LID - 15 [pii] LID - 10.3390/dietetics4020015 [doi] AB - INTRODUCTION: This is a secondary cross-sectional analysis of participants' baseline data from the Baby-Act Trial to compare energy and macronutrients intake by feeding type. This was a cluster-randomized clinical trial among pregnant women and their infants participating in the Puerto Rico WIC program to test the clinical effectiveness of an intervention that addressed various infant obesity risk factors during the first year of life. METHODS: Participants completed at baseline a sociodemographic questionnaire and a validated infant food frequency questionnaire (FFQ). The FFQ was analyzed for type of feeding (exclusively fed breastmilk, fed breastmilk and formula, or exclusively fed infant formula) and for energy and macronutrient intake (protein, carbohydrate, and fat). Analysis of covariance was used to compare intake type of feeding, adjusting for maternal age. race, education, number of previous children, gestational length, and pre-pregnancy BMI. RESULTS: The present analysis included 368 mother-infant pairs. Mean age of mothers was 26.7 years and of infants 0.7 months. Ten infants fed complementary foods were removed from the analyses. A total of 39.9% of infants were exclusively breastmilk-fed, 47.2% were fed breastmilk and infant formula, and 12.8% were exclusively formula-fed (n = 358). Intake of energy, protein, fat, and carbohydrates was significantly lower in infants fed only breastmilk compared to infants fed a combination of breastmilk and infant formula, and intake of protein and carbohydrates were lower in infants fed a combination of breastmilk and infant formula compared to infants fed only infant formula, after adjusting for important confounders. CONCLUSIONS: Very early infant feeding practices are associated with differences in dietary intake. The long-term health implications of this findings need to be further studied. FAU - Palacios, Cristina AU - Palacios C AD - Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, Miami, FL 33199, USA. FAU - Alvarez, Elvira AU - Alvarez E AD - Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, Miami, FL 33199, USA. FAU - Kallis, Maria Gabriela AU - Kallis MG AD - Center for Community Outreach for Health Across the Lifespan (COHeAL), School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan P.O. Box 365067, Puerto Rico. FAU - Valle, Yari AU - Valle Y AD - Center for Community Outreach for Health Across the Lifespan (COHeAL), School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan P.O. Box 365067, Puerto Rico. FAU - Pomeroy, Jeremy AU - Pomeroy J AD - Fritz Wenzel Center for Clinical Research, Marshfield, WI 54449, USA. FAU - Campos, Maribel AU - Campos M AD - Center for Community Outreach for Health Across the Lifespan (COHeAL), School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan P.O. Box 365067, Puerto Rico. LA - eng GR - U54 GM133807/GM/NIGMS NIH HHS/United States GR - U54 MD007600/MD/NIMHD NIH HHS/United States PT - Journal Article DEP - 20250404 PL - Switzerland TA - Dietetics (Basel) JT - Dietetics (Basel, Switzerland) JID - 9918646274806676 PMC - PMC12392266 MID - NIHMS2083759 OTO - NOTNLM OT - Puerto Rico OT - WIC OT - diet OT - feeding OT - infant COIS- Conflicts of Interest: The authors declare no conflict of interest. EDAT- 2025/09/02 22:31 MHDA- 2025/09/02 22:32 PMCR- 2025/08/29 CRDT- 2025/09/02 16:45 PHST- 2025/09/02 22:32 [medline] PHST- 2025/09/02 22:31 [pubmed] PHST- 2025/09/02 16:45 [entrez] PHST- 2025/08/29 00:00 [pmc-release] AID - 15 [pii] AID - 10.3390/dietetics4020015 [doi] PST - ppublish SO - Dietetics (Basel). 2025 Jun;4(2):15. doi: 10.3390/dietetics4020015. Epub 2025 Apr 4. PMID- 40893473 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250905 IS - 1015-5759 (Print) IS - 2151-2426 (Electronic) IS - 1015-5759 (Linking) VI - 41 IP - 4 DP - 2025 Jul TI - Development and validation of the Parental Food Choice Guilt Scale. PG - 319-332 LID - 10.1027/1015-5759/a000800 [doi] AB - Guilt is an important correlate of the food choices parents make for their children. However, without a validated self-report measure of feeding-related guilt, researchers remain unable to reliably assess its consequences for parents and children. This study developed and validated the Parental Food Choice Guilt (PFCG) Scale. Items were iteratively developed based on feedback from parents and content experts and refined through three preliminary rounds of data collection. The final 7-item PFCG was evaluated using an internet-based sample of 294 parents (194 mothers, 99 fathers) of children aged 3-13. Participants responded to the PFCG alongside measures of child eating habits, parent feeding behavior, and guilt-proneness. Exploratory factor analysis indicated unidimensionality of the underlying construct. A Graded Response Model indicated all items functioned well psychometrically. Internal consistency was high (Cronbach's alpha = 0.90). Differential item functioning was not detected by parent gender, parent or child weight status, or parent education. The PFCG was positively correlated with global guilt, parenting-related guilt, and poorer child eating habits, and negatively correlated with feeding self-efficacy and healthfulness of the child's diet. The PFCG is a reliable and valid measure that will aid researchers across many applications, including clarifying guilt's role in child feeding. FAU - Yaremych, Haley E AU - Yaremych HE AD - Department of Psychology & Human Development, Vanderbilt University. AD - Social & Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health. FAU - Persky, Susan AU - Persky S AD - Social & Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health. LA - eng GR - ZIA HG200396/ImNIH/Intramural NIH HHS/United States PT - Journal Article DEP - 20231106 PL - Switzerland TA - Eur J Psychol Assess JT - European journal of psychological assessment : official organ of the European Association of Psychological Assessment JID - 9431864 PMC - PMC12393093 MID - NIHMS2099002 OTO - NOTNLM OT - child feeding OT - guilt OT - item response theory OT - measurement OT - parents EDAT- 2025/09/02 22:33 MHDA- 2025/09/02 22:34 PMCR- 2025/08/29 CRDT- 2025/09/02 16:29 PHST- 2025/09/02 22:34 [medline] PHST- 2025/09/02 22:33 [pubmed] PHST- 2025/09/02 16:29 [entrez] PHST- 2025/08/29 00:00 [pmc-release] AID - 10.1027/1015-5759/a000800 [doi] PST - ppublish SO - Eur J Psychol Assess. 2025 Jul;41(4):319-332. doi: 10.1027/1015-5759/a000800. Epub 2023 Nov 6. PMID- 40892774 OWN - NLM STAT- MEDLINE DCOM- 20250902 LR - 20250904 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 9 DP - 2025 TI - The role of physical acgtivity in life satisfaction and psychological resilience among college students: Mediating effects of self-efficacy and perceived stress. PG - e0331463 LID - 10.1371/journal.pone.0331463 [doi] LID - e0331463 AB - BACKGROUND: With the increasing global attention on mental health issues, especially the psychological stress and life satisfaction problems faced by college students, it has become particularly important to explore how physical activity is associated with college students' psychological resilience and quality of life through psychological mechanisms. This study aims to examine the association between physical activity on college students' life satisfaction and psychological resilience, and to investigate the mediating roles of self-efficacy and perceived stress. METHODS: This study collected data from college students in several universities in China through online questionnaires, using the Body Self-Concept Questionnaire, Life Satisfaction Scale, the Chinese Revised Version of the Connor-Davidson Resilience Scale, General Self-Efficacy Scale, and Perceived Stress Scale to measure each variable. A total of 560 undergraduate students from three universities participated in the survey, reporting on their physical activity, life satisfaction, psychological resilience, self-efficacy, and perceived stress. RESULTS: The findings show that physical activity was significantly associated with higher life satisfaction (r = 0.439, p < 0.001) and psychological resilience (r = 0.521, p < 0.001). Both self-efficacy (95% CI = [0.138, 0.255] and [0.245, 0.399]) and perceived stress (95% CI = [0.013, 0.070] and [0.040, 0.134]) played significant mediating roles in these processes. Specifically, physical activity was linked to better mental health and quality of life through its association with higher self-efficacy and lower perceived stress. DISCUSSION AND IMPLICATIONS: This study validates the association between physical activity and improved college students' life satisfaction and psychological resilience and reveals the mediating mechanisms of self-efficacy and perceived stress. These findings provide a scientific basis for designing exercise and psychological intervention programs for college students, with important practical implications. CI - Copyright: (c) 2025 Rujiang Zhang. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Zhang, Rujiang AU - Zhang R AUID- ORCID: 0009-0001-5466-1280 AD - College of Education and Sports Sciences, Yangtze University, Jingzhou, Hubei, China. LA - eng PT - Journal Article DEP - 20250902 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Self Efficacy MH - Male MH - Female MH - *Students/psychology MH - *Personal Satisfaction MH - *Stress, Psychological/psychology MH - Universities MH - Young Adult MH - *Resilience, Psychological MH - *Exercise/psychology MH - Surveys and Questionnaires MH - Adult MH - Quality of Life/psychology MH - Adolescent MH - China PMC - PMC12404461 COIS- The authors have no competing interests to declare that are relevant to the content of this article. EDAT- 2025/09/02 22:20 MHDA- 2025/09/03 02:18 PMCR- 2025/09/02 CRDT- 2025/09/02 13:43 PHST- 2025/04/24 00:00 [received] PHST- 2025/08/16 00:00 [accepted] PHST- 2025/09/03 02:18 [medline] PHST- 2025/09/02 22:20 [pubmed] PHST- 2025/09/02 13:43 [entrez] PHST- 2025/09/02 00:00 [pmc-release] AID - PONE-D-25-20237 [pii] AID - 10.1371/journal.pone.0331463 [doi] PST - epublish SO - PLoS One. 2025 Sep 2;20(9):e0331463. doi: 10.1371/journal.pone.0331463. eCollection 2025. PMID- 40891066 OWN - NLM STAT- MEDLINE DCOM- 20250902 LR - 20250905 IS - 1365-277X (Electronic) IS - 0952-3871 (Print) IS - 0952-3871 (Linking) VI - 38 IP - 5 DP - 2025 Oct TI - Dietary Patterns Among Patients With Beta-Thalassemia Major in Vietnam. PG - e70120 LID - 10.1111/jhn.70120 [doi] LID - e70120 AB - INTRODUCTION: Patients with beta-thalassemia major (BTM) are vulnerable to imbalanced diets due to treatment-related complications and dietary restrictions. Despite the high prevalence of BTM in Vietnam, no studies to date have examined dietary patterns in this population. This study aims to explore the dietary patterns of adult patients with BTM in Vietnam. METHODS: This secondary data analysis included 317 adult patients with BTM receiving treatment at the largest haematology institute in Vietnam. Dietary patterns were assessed using the validated Vietnamese version of a 24-h recall diet quality questionnaire. Additional variables included diet quality indices, underweight status, malnutrition risk, and sociodemographic characteristics. Exploratory factor analysis was used to derive dietary patterns from 12 food groups. Comparisons of diet quality, nutritional status, and other covariates were made across identified dietary patterns. RESULTS: Four dietary patterns were identified: ready-to-eat (36.0%), plant-based convenience (29.3%), red meat-based (21.5%), and seafood-based (13.2%). Participants following ready-to-eat and red meat-based patterns had significantly higher non-communicable diseases (NCD)-risk score than participants of other patterns. The global dietary recommendation score was significantly highest among those in the plant-based convenience and seafood-based groups, and lowest in the red meat-based group. The prevalence of underweight and risk of malnutrition was high across all patients, regardless of their dietary patterns. CONCLUSION: The predominance of ready-to-eat and red meat-based dietary patterns among patients with BTM is concerning, as these patterns had significantly higher NCD risk and lower adherence to global dietary guidelines. These issues are exacerbated by high rates of underweight and malnutrition risk. We recommend integrating routine nutrition screening and counselling into BTM care and developing evidence-based dietary guidelines to support healthier eating practices in this population. CI - (c) 2025 The Author(s). Journal of Human Nutrition and Dietetics published by John Wiley & Sons Ltd on behalf of British Dietetic Association. FAU - Hoang, Thi Ngoc Anh AU - Hoang TNA AD - Faculty of Public Health, School of Medicine and Pharmacy, PHENIKAA University, Hanoi, Vietnam. FAU - Quach, Ha-Linh AU - Quach HL AUID- ORCID: 0000-0001-7160-8329 AD - Prevention Research Collaboration, School of Public Health, The University of Sydney, Camperdown, New South Wales, Australia. LA - eng GR - This study was funded by PHENIKAA University under grant number PU2023-2-D-09/DHP-DHNCKHCS./ PT - Journal Article PL - England TA - J Hum Nutr Diet JT - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JID - 8904840 SB - IM MH - Humans MH - Vietnam/epidemiology MH - Male MH - Female MH - *beta-Thalassemia/epidemiology/complications MH - Adult MH - *Diet/statistics & numerical data/methods MH - Nutritional Status MH - Middle Aged MH - Young Adult MH - *Feeding Behavior MH - Malnutrition/epidemiology MH - Thinness/epidemiology MH - Surveys and Questionnaires MH - Fast Foods MH - Adolescent MH - Cross-Sectional Studies MH - Noncommunicable Diseases/epidemiology PMC - PMC12402677 OTO - NOTNLM OT - Vietnam OT - beta-thalassemia major OT - diet quality OT - dietary pattern OT - malnutrition OT - underweight COIS- The authors declare no conflicts of interest. EDAT- 2025/09/02 08:44 MHDA- 2025/09/02 08:45 PMCR- 2025/09/02 CRDT- 2025/09/02 02:12 PHST- 2025/08/19 00:00 [revised] PHST- 2025/06/15 00:00 [received] PHST- 2025/08/21 00:00 [accepted] PHST- 2025/09/02 08:45 [medline] PHST- 2025/09/02 08:44 [pubmed] PHST- 2025/09/02 02:12 [entrez] PHST- 2025/09/02 00:00 [pmc-release] AID - JHN70120 [pii] AID - 10.1111/jhn.70120 [doi] PST - ppublish SO - J Hum Nutr Diet. 2025 Oct;38(5):e70120. doi: 10.1111/jhn.70120. PMID- 40839857 OWN - NLM STAT- MEDLINE DCOM- 20250821 LR - 20250903 IS - 1941-4935 (Electronic) IS - 1941-4927 (Print) IS - 1941-4935 (Linking) IP - 527 DP - 2025 Apr TI - Depression Prevalence in Adolescents and Adults: United States, August 2021-August 2023. PG - 1 LID - 10.15620/cdc/174579 [doi] AB - INTRODUCTION: This report presents the most recent depression prevalence estimates in adolescents and adults, ages 12 years and older, based on the August 2021-August 2023 National Health and Nutrition Examination Survey (NHANES). Depression symptoms are measured using the Patient Health Questionnaire. METHODS: Prevalence of depression was estimated using August 2021-August 2023 NHANES data. Depression was defined by score of 10 or greater on the Patient Health Questionnaire (PHQ-9), a validated screening instrument used to assess depression symptoms in the past 2 weeks. Standard errors of percentages were estimated using Taylor series linearization. A t statistic was used to test for differences between groups. Linear and nonlinear trends were evaluated using the orthogonal polynomials. The significance level for statistical testing was p < 0.05. KEY FINDINGS: During August 2021-August 2023, depression prevalence was 13.1% in adolescents and adults ages 12 years and older and decreased with increasing age. Depression prevalence decreased with increasing family income overall and in males and females. From 2013-2014 to August 2021-August 2023, the prevalence of depression increased overall, and in males and females. Among adolescents and adults with depression, 87.9% reported at least some difficulty with work, home, or social activities due to their depression symptoms, and a higher percentage of females (43.0%) than males (33.2%) reported receiving therapy or counseling in the past 12 months. FAU - Brody, Debra J AU - Brody DJ FAU - Hughes, Jeffery P AU - Hughes JP LA - eng PT - Journal Article PL - United States TA - NCHS Data Brief JT - NCHS data brief JID - 101495625 SB - IM MH - Humans MH - Adolescent MH - Male MH - United States/epidemiology MH - Female MH - Adult MH - Prevalence MH - Young Adult MH - Child MH - *Depression/epidemiology MH - Nutrition Surveys MH - Middle Aged MH - Aged MH - Sex Distribution MH - Age Distribution PMC - PMC12400127 EDAT- 2025/09/02 04:45 MHDA- 2025/09/02 04:46 PMCR- 2025/09/01 CRDT- 2025/08/21 16:23 PHST- 2025/09/02 04:46 [medline] PHST- 2025/09/02 04:45 [pubmed] PHST- 2025/08/21 16:23 [entrez] PHST- 2025/09/01 00:00 [pmc-release] AID - 10.15620/cdc/174579 [doi] PST - ppublish SO - NCHS Data Brief. 2025 Apr;(527):1. doi: 10.15620/cdc/174579. PMID- 40888575 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 2047-945X (Electronic) IS - 0260-1060 (Print) IS - 0260-1060 (Linking) VI - 32 IP - 4 DP - 2026 Jul TI - Measuring breakfast dietary patterns in Spanish youth: Reliability of the Spanish Youth Breakfast Consumption Questionnaire (SYBC-Q). PG - 1265-1273 LID - 10.1177/02601060251368960 [doi] AB - Background: Reliable tools to assess breakfast habits are essential, as breakfast quality is linked to health and development in youth. However, validated instruments for Spanish children and adolescents are scarce. Objectives: To assess the reliability of the Spanish Youth Breakfast Consumption Questionnaire (SYBC-Q) in a sample of Spanish children and adolescents. Methods: A total of 248 young people participated in the study: 77 children (46.8% girls; 10.7 +/- 0.7 years) and 171 adolescents (50.3% girls; 14.1 +/- 1.7 years). They completed the questionnaire twice, 14 days apart, on the same days of the week and schedule. The tool includes 21 items grouped into seven food categories and two breakfast quality scores. Test-retest reliability was analyzed using the kappa coefficient (kappa) and Spearman's correlation (Rho). Analyses were performed separately by age group and gender. Results: Children showed an acceptable to good level of agreement and a moderate to high correlation between test and retest (kappa: 0.23-0.71; Rho: 0.37-0.76). However, low agreement and poor correlation were found for 'Take Cheese' and 'Take Milk dessert' in girls (both, kappa < 0.20; Rho < 0.30). Adolescents presented an acceptable to perfect level of agreement and a low to high correlation between test and retest (kappa: 0.24-0.82; Rho: 0.24-0.82), but a low level of agreement in the items 'Take pate' in girls and 'Take dried fruits' in boys (both, kappa: < 0.20; Rho: < 0.30). Conclusion: Overall, the SYBC-Q is a reliable tool for assessing the breakfast consumption and quality in Spanish children and adolescents. FAU - Campos-Garzon, Pablo AU - Campos-Garzon P AUID- ORCID: 0000-0003-0418-9165 AD - Faculty of Health Sciences, University of Lethbridge, Lethbridge, AB, Canada. RINGGOLD: 4512 AD - Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. FAU - Saucedo-Araujo, Romina Gisele AU - Saucedo-Araujo RG AUID- ORCID: 0000-0002-0194-4236 AD - Department of Physical Education and Sports, Faculty of Education and Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Melilla, Spain. RINGGOLD: 16741 FAU - Herrador-Colmenero, Manuel AU - Herrador-Colmenero M AUID- ORCID: 0000-0003-2145-4725 AD - La Inmaculada Teacher Training Centre, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. RINGGOLD: 16741 FAU - Barranco-Ruiz, Yaira AU - Barranco-Ruiz Y AUID- ORCID: 0000-0002-7435-7702 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. RINGGOLD: 16741 LA - eng PT - Journal Article PT - Validation Study DEP - 20250901 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 SB - IM MH - Humans MH - *Breakfast MH - Female MH - Adolescent MH - Child MH - Male MH - Spain MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - *Feeding Behavior MH - *Diet Surveys MH - *Diet PMC - PMC13365622 OTO - NOTNLM OT - Test-retest OT - breakfast composition OT - breakfast quality OT - dietary patterns OT - youth COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/09/01 16:45 MHDA- 2026/07/07 12:33 PMCR- 2026/07/14 CRDT- 2025/09/01 08:32 PHST- 2026/07/07 12:33 [medline] PHST- 2025/09/01 16:45 [pubmed] PHST- 2025/09/01 08:32 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - 10.1177_02601060251368960 [pii] AID - 10.1177/02601060251368960 [doi] PST - ppublish SO - Nutr Health. 2026 Jul;32(4):1265-1273. doi: 10.1177/02601060251368960. Epub 2025 Sep 1. PMID- 40885946 OWN - NLM STAT- MEDLINE DCOM- 20250831 LR - 20250902 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 24 IP - 1 DP - 2025 Aug 30 TI - Adherence to EAT-Lancet diet and odds of irritable bowel syndrome and functional dyspepsia: the Isfahan functional disorders (ISFUN) study. PG - 134 LID - 10.1186/s12937-025-01195-5 [doi] LID - 134 AB - BACKGROUND: No study has been conducted to investigate the association between adherence to the EAT-Lancet diet and odds of irritable bowel syndrome (IBS) and functional dyspepsia (FD). This cross-sectional study was aimed to assess the association between adherence to the EAT-Lancet diet and odds of IBS and FD. METHODS: This cross-sectional analysis was done among 1892 Iranian apparently healthy adults, aged 18 to 65 years, in Isfahan, Iran. Usual dietary intakes of participants were assessed using a validated Dish-based, 106-item food frequency questionnaire. To measure participants' adherence to the EAT-Lancet diet, the EAT-Lancet diet index (ELD-I) was calculated. IBS and FD were assessed using ROME IV criteria. RESULTS: In total, 5.29% and 3.17% of participants had IBS and FD, respectively. The mean age of study participants was 39.64 +/- 10.24 years, and the mean BMI was 27.08 +/- 4.91 kg/m(2). After adjustment for potential confounding factors, a significant positive association between lower adherence to the EAT-Lancet diet and odds of IBS was revealed (OR: 1.74; 95% CI: 1.00-3.04), but not for FD (OR: 1.37; 95% CI: 0.65-2.89). CONCLUSION: A significant positive association was observed between lower adherence to EAT-Lancet diet and odds of IBS. More prospective studies are needed to affirm these associations. CI - (c) 2025. The Author(s). FAU - Salari-Moghaddam, Asma AU - Salari-Moghaddam A AD - Health and Environment Research Center, Ilam University of Medical Sciences, Ilam, Iran. AD - Department of Public Health, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran. FAU - Feizi, Awat AU - Feizi A AD - Department of Epidemiology and Biostatistics, School of Health, and Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Hajihashemi, Parisa AU - Hajihashemi P AD - Isfahan Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. hashemi_p@yahoo.com. FAU - Ani, Alireza AU - Ani A AD - Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Roohafza, Hamidreza AU - Roohafza H AD - Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Adibi, Peyman AU - Adibi P AD - Isfahan Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. LA - eng PT - Journal Article DEP - 20250830 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 SB - IM MH - Humans MH - *Irritable Bowel Syndrome/epidemiology MH - Adult MH - *Dyspepsia/epidemiology MH - Male MH - Female MH - Iran/epidemiology MH - Cross-Sectional Studies MH - Middle Aged MH - Young Adult MH - Aged MH - Adolescent MH - *Diet MH - Surveys and Questionnaires MH - Body Mass Index PMC - PMC12398959 OTO - NOTNLM OT - Disorders of gut-brain interaction OT - EAT-Lancet diet OT - ELD-I OT - Functional gastrointestinal disorders COIS- Declarations. Ethics approval and consent to participate: The National Research Ethics Committee of the Iranian Ministry of Health and Medical Education and the Research Ethics Committee of Isfahan University of Medical Sciences (IR.MUI.REC.1395.1.149). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/09/01 04:45 MHDA- 2025/09/01 04:46 PMCR- 2025/08/30 CRDT- 2025/08/30 23:35 PHST- 2025/01/02 00:00 [received] PHST- 2025/07/28 00:00 [accepted] PHST- 2025/09/01 04:46 [medline] PHST- 2025/09/01 04:45 [pubmed] PHST- 2025/08/30 23:35 [entrez] PHST- 2025/08/30 00:00 [pmc-release] AID - 10.1186/s12937-025-01195-5 [pii] AID - 1195 [pii] AID - 10.1186/s12937-025-01195-5 [doi] PST - epublish SO - Nutr J. 2025 Aug 30;24(1):134. doi: 10.1186/s12937-025-01195-5. PMID- 40883728 OWN - NLM STAT- MEDLINE DCOM- 20250830 LR - 20250902 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Aug 29 TI - Health literacy and its determinants among pregnant women in Portugal. PG - 2963 LID - 10.1186/s12889-025-24225-7 [doi] LID - 2963 AB - BACKGROUND: Health literacy is a key determinant of health outcomes and equity, particularly during pregnancy, a period marked by increased information needs and critical health decisions. Despite its importance, data on health literacy among pregnant women in Portugal remain scarce. This study aimed to assess general health literacy levels and their associations with sociodemographic, health-related, and pregnancy-specific factors in a large sample of pregnant women from the district of Viseu, Portugal. METHODS: A cross-sectional study was conducted with 886 pregnant women aged 18 years or older, using the validated HLS(19)-Q12 instrument to measure general health literacy. Data collection occurred between October 2023 and May 2024 using a multimodal approach (online, interview, and paper-based). Health literacy was categorized into four levels and also dichotomized as limited versus not limited. Descriptive statistics, bivariate analyses, and binary logistic regression were performed to identify determinants of limited health literacy. RESULTS: The mean general health literacy score was 68.3 (SD +/- 10.9). A total of 46.7% of participants were classified as having limited health literacy. Among the pregnant women surveyed, 18.8% were born outside Portugal. Of these, 74.7% were classified as having limited health literacy, compared to 40.2% among Portuguese-born participants. Higher prevalence was observed among women aged 18-29, those born outside Portugal, with lower education, in undifferentiated professions, and facing financial hardship. In the final adjusted logistic regression model, which combined variables selected through forward stepwise inclusion with theoretically important covariates entered in a second block, significant predictors of limited health literacy included being born outside Portugal (adjusted OR 2.43; 95% CI: 1.56-3.80), having lower education (up to high school), holding lower-skilled occupations, financial difficulties, and rating current health as equal or worse. Pre-pregnancy Body Mass Index was also negatively associated with health literacy levels, with higher BMI more prevalent among women with limited health literacy. The model showed good discriminatory ability (area under the ROC curve = 0.78). CONCLUSIONS: A considerable proportion of pregnant women demonstrated limited health literacy, particularly among socioeconomically vulnerable and migrant groups. These findings underscore the urgency of adopting antenatal care approaches that are responsive to health literacy needs. Incorporating brief assessments during early prenatal visits, using plain language and visual communication tools, and offering targeted support to high-risk groups may enhance informed decision-making, promote equity, and improve maternal and neonatal outcomes. CI - (c) 2025. The Author(s). FAU - Ferreira, Nuno AU - Ferreira N AD - Nursing Research, Innovation and Development Centre of Lisbon (CIDNUR), Nursing School of Lisbon, Av. Prof. Egas Moniz, Lisbon, 1600-190, Portugal. nmoferreira@gmail.com. AD - University of Lisbon (UL)/Lisbon Higher School of Nursing (ESEL), Lisbon, 1600-190, Portugal. nmoferreira@gmail.com. FAU - Ferreira, Manuela AU - Ferreira M AD - Polytechnic Institute of Viseu, Higher School of Health, Viseu, 3500-843, Portugal. AD - Health Sciences Research Unit: Nursing (UICISA: E), Coimbra, 3001-901, Portugal. FAU - Santos, Eduardo AU - Santos E AD - Polytechnic Institute of Viseu, Higher School of Health, Viseu, 3500-843, Portugal. AD - Health Sciences Research Unit: Nursing (UICISA: E), Coimbra, 3001-901, Portugal. AD - Portugal Center for Evidence Based Practice (PCEBP), A JBI Centre of Excellence, Coimbra, 3001-901, Portugal. FAU - Ferreira, Sofia AU - Ferreira S AD - Health Sciences Research Unit: Nursing (UICISA: E), Coimbra, 3001-901, Portugal. AD - University of Coimbra/Coimbra Higher School of Nursing, Coimbra, 3001-901, Portugal. FAU - de Arriaga, Miguel Telo AU - de Arriaga MT AD - Directorate of Disease Prevention and Health Promotion, Lisbon, 1049-005, Portugal. AD - Instituto de Saude Ambiental da Faculdade de Medicina da Universidade de Lisboa, TERRA laboratory, Av. Prof. Egas Moniz, Lisbon, 1649-028, Portugal. FAU - Costa, Andreia AU - Costa A AD - Nursing Research, Innovation and Development Centre of Lisbon (CIDNUR), Nursing School of Lisbon, Av. Prof. Egas Moniz, Lisbon, 1600-190, Portugal. AD - Instituto de Saude Ambiental da Faculdade de Medicina da Universidade de Lisboa, TERRA laboratory, Av. Prof. Egas Moniz, Lisbon, 1649-028, Portugal. LA - eng PT - Journal Article DEP - 20250829 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - Portugal MH - *Health Literacy/statistics & numerical data MH - Adult MH - Pregnancy MH - Cross-Sectional Studies MH - *Pregnant People/psychology MH - Young Adult MH - Adolescent MH - Surveys and Questionnaires MH - Socioeconomic Factors PMC - PMC12395654 OTO - NOTNLM OT - Health inequities OT - Health literacy OT - Maternal health OT - Pregnant women OT - Prenatal care OT - Public health OT - Social determinants of health COIS- Declarations. Ethics approval and consent to participate: Informed consent was obtained from all participants before any procedure. The study was previously approved by the Institutional Health Ethics Committees of the Hospital Center Tondela-Viseu (reference 29/13/09/2023) and the Central Regional Health Administration (process number 124-2023). Furthermore, all procedures followed the Code of Ethics of the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/09/01 16:44 MHDA- 2025/09/01 16:45 PMCR- 2025/08/29 CRDT- 2025/08/29 23:42 PHST- 2025/04/07 00:00 [received] PHST- 2025/07/29 00:00 [accepted] PHST- 2025/09/01 16:45 [medline] PHST- 2025/09/01 16:44 [pubmed] PHST- 2025/08/29 23:42 [entrez] PHST- 2025/08/29 00:00 [pmc-release] AID - 10.1186/s12889-025-24225-7 [pii] AID - 24225 [pii] AID - 10.1186/s12889-025-24225-7 [doi] PST - epublish SO - BMC Public Health. 2025 Aug 29;25(1):2963. doi: 10.1186/s12889-025-24225-7. PMID- 40886097 OWN - NLM STAT- MEDLINE DCOM- 20260211 LR - 20260826 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 1 DP - 2026 Mar TI - Tuning Into Affect and Appetite in Caregivers, and Its Association With Recognising and Responding to Infant Appetite Cues. PG - e70099 LID - 10.1111/mcn.70099 [doi] LID - e70099 AB - Positive mealtime interactions shape infant eating patterns potentially promoting appetite regulation. This study investigated whether caregivers who "tune-in" to their own internal affect and appetite cues, can also recognise and respond to their infant's appetite cues via responsive feeding (RF). Caregivers (N = 445; mean age: 33.5 +/- 4.7 years) with children aged 5-28 m participated in an online survey in August 2023. Caregivers' RF practices, mealtime emotions, eating traits, alexithymia (impaired capacity to identify and express emotions) and their infant's eating traits were administered using validated questionnaires. Recent mealtime experiences were described through an open-ended question. Caregivers who relied on interoceptive cues in eating scored high on recognising infant appetite cues (R(2) = 0.11, F(1, 396) = 5.40, p < 0.001). Whereas caregivers with alexithymia reported poorer ability to recognise infant appetite cues (R(2) = 0.12, F(7, 399) = 7.53, p < 0.001) and less positive mealtime emotions (R(2) = 0.12, F(7, 399) = 7.49, p < 0.001) compared to those without alexithymia. Caregivers' capacity to "tune-in" to their own internal satiation cues inversely mediated the relationship between caregivers' alexithymia and their recognition of infant mealtime appetite cues. Infant eating traits (Food Responsiveness and Satiety Responsiveness) were associated with parental use of food to calm. Overall, RF was associated with mealtime emotions, parental ability to "tune-in" to their own affect (alexithymia) and appetite, and child's appetitive traits. Developing caregiver's awareness and responsiveness to their own and their child's affect and appetite cues may promote RF practices. CI - (c) 2026 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Yu, Shihui AU - Yu S AUID- ORCID: 0000-0003-3760-162X AD - School of Psychology, University of Leeds, Leeds, UK. FAU - Fildes, Alison AU - Fildes A AUID- ORCID: 0000-0002-5452-2512 AD - School of Psychology, University of Leeds, Leeds, UK. FAU - Birtill, Pam AU - Birtill P AUID- ORCID: 0000-0002-4690-2558 AD - School of Psychology, University of Leeds, Leeds, UK. FAU - Tang, Tang AU - Tang T AUID- ORCID: 0000-0002-5410-7271 AD - School of Design, University of Leeds, Leeds, UK. FAU - Hetherington, Marion M AU - Hetherington MM AUID- ORCID: 0000-0001-8677-5234 AD - School of Psychology, University of Leeds, Leeds, UK. LA - eng PT - Journal Article DEP - 20250831 PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - Female MH - Male MH - *Appetite/physiology MH - *Caregivers/psychology MH - *Cues MH - Adult MH - Infant MH - Child, Preschool MH - *Feeding Behavior/psychology MH - Surveys and Questionnaires MH - Meals/psychology MH - *Affect MH - Affective Symptoms/psychology MH - Emotions MH - Young Adult PMC - PMC12893506 OTO - NOTNLM OT - affect OT - alexithymia OT - appetite OT - eating traits OT - infants OT - responsive feeding COIS- The authors declare no conflicts of interest. EDAT- 2025/08/31 08:44 MHDA- 2026/02/11 18:59 PMCR- 2025/08/31 CRDT- 2025/08/31 05:42 PHST- 2025/07/11 00:00 [revised] PHST- 2025/02/20 00:00 [received] PHST- 2025/08/06 00:00 [accepted] PHST- 2026/02/11 18:59 [medline] PHST- 2025/08/31 08:44 [pubmed] PHST- 2025/08/31 05:42 [entrez] PHST- 2025/08/31 00:00 [pmc-release] AID - MCN70099 [pii] AID - 10.1111/mcn.70099 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Mar;22(1):e70099. doi: 10.1111/mcn.70099. Epub 2025 Aug 31. PMID- 40881082 OWN - NLM STAT- In-Process LR - 20250910 IS - 2219-2808 (Print) IS - 2219-2808 (Electronic) IS - 2219-2808 (Linking) VI - 14 IP - 3 DP - 2025 Sep 9 TI - Effects of body mass index on gastric motility: Comparing children with functional abdominal pain disorders and healthy controls. PG - 100306 LID - 10.5409/wjcp.v14.i3.100306 [doi] LID - 100306 AB - BACKGROUND: Overweight children exhibit a higher prevalence of functional gastrointestinal disorders compared with their normal-weight peers, yet the underlying reasons remain unclear. Gastrointestinal motility, a key pathophysiological factor in functional gastrointestinal disorders, may be influenced by body mass index (BMI). AIM: To evaluate the impact of BMI on gastric motility parameters in children with functional abdominal pain disorders (FAPDs). METHODS: We assessed gastric motility in 176 children with FAPDs (61.4% females, mean age 7.94 years, SD 1.96 years) and 63 healthy controls (57.1% females, mean age 9.17 years, SD 1.90 years) at the Gastroenterology Research Laboratory, University of Kelaniya, Sri Lanka. FAPDs were diagnosed and subtyped using the Rome IV criteria: Functional abdominal pain 97 patients; irritable bowel syndrome 39 patients, functional dyspepsia (FD) 25 patients; and abdominal migraine 15 patients. Gastric motility was measured using a validated ultrasound method. Weight and height were measured using sensitive standard scales. RESULTS: The BMIs of children with FAPDs and controls were 15.04 and 15.46 kg/m(2), respectively (P = 0.33). Fasting antral area (FAA) and antral area at 1 min (AA1) and 15 min (AA15) were significantly greater in patients with FAPD with a higher BMI (2.71 cm(2), 12.57 cm(2), and 7.19 cm(2), respectively) compared with those with a lower BMI (2.12 cm(2), 10.68 cm(2), and 6.13 cm(2), respectively) (P < 0.01). BMI positively correlated with FAA and AA15 (r = 0.18 and r = 0.19, respectively) (P < 0.01) in those with FAPDs. In controls, only AA1 was greater in the higher BMI group (12.51 cm(2) vs 9.93 cm(2)) and had a positive correlation (r = 0.33) (P BACKGROUNDEffective TB treatment requires consistent adherence, yet traditional assessments focus solely on medication intake and may miss important lifestyle factors. This study aimed to develop and evaluate the psychometric properties of the Adherence to TB Treatment Scale (ATTS), a new instrument covering both medication intake and lifestyle behaviours.METHODThe development followed seven steps: 1) defining TB treatment adherence through literature synthesis and a Delphi study, 2) generating an item pool from an extensive literature review, 3) using a four-point Likert scale for measurement, 4) assessing item validity, 5) conducting preliminary studies, 6) performing factor analysis, and 7) finalising the scale. Seven components were identified: medication-taking behaviour, nutritional care, substance use cessation, stress management, physical activity, sleep quality, and preventive behaviours.RESULTSThe ATTS showed strong content validity (content validity index = 0.92) and reliability (Cronbach's alpha = 0.894). Exploratory factor analysis identified 33 items across seven domains. Confirmatory factor analysis indicated a good model fit: chi(2)/df = 1.97, comparative fit index = 0.94, Tucker-Lewis index = 0.88, root mean square error of approximation = 0.066, and standardised root mean square residual = 0.054.CONCLUSIONThe ATTS is a reliable and valid tool for assessing TB treatment adherence, including both medication and lifestyle factors, with applications in clinical practice, nursing education, and research.. FAU - Prasetyo, Y A AU - Prasetyo YA AD - Faculty of Nursing, Chulalongkorn University, Pathum Wan, Thailand. FAU - Thanasilp, S AU - Thanasilp S AD - Faculty of Nursing, Chulalongkorn University, Pathum Wan, Thailand;, Director of Asian Wisdom Care Research Unit, Chulalongkorn University, Pathum Wan, Thailand. FAU - Preechawong, S AU - Preechawong S AD - Faculty of Nursing, Chulalongkorn University, Pathum Wan, Thailand. LA - eng PT - Evaluation Study PT - Journal Article PT - Multicenter Study PL - France TA - Int J Tuberc Lung Dis JT - The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease JID - 9706389 RN - 0 (Antitubercular Agents) SB - IM MH - *Tuberculosis, Pulmonary/drug therapy/psychology MH - *Antitubercular Agents/therapeutic use MH - *Psychometrics/methods MH - Medication Adherence/psychology MH - *Patient Compliance/psychology/statistics & numerical data MH - Exercise MH - Sleep MH - *Healthy Lifestyle MH - Indonesia MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged MH - Delphi Technique MH - Drug Monitoring EDAT- 2025/08/30 08:45 MHDA- 2025/08/30 08:46 CRDT- 2025/08/30 00:42 PHST- 2025/08/30 08:46 [medline] PHST- 2025/08/30 08:45 [pubmed] PHST- 2025/08/30 00:42 [entrez] AID - 10.5588/ijtld.24.0548 [doi] PST - ppublish SO - Int J Tuberc Lung Dis. 2025 Aug 29;29(9):410-415. doi: 10.5588/ijtld.24.0548. PMID- 40883121 OWN - NLM STAT- MEDLINE DCOM- 20251217 LR - 20251230 IS - 1590-3729 (Electronic) IS - 0939-4753 (Linking) VI - 36 IP - 1 DP - 2026 Jan TI - Validation of an Italian questionnaire on knowledge and perceived effects on health of Mediterranean Diet and other dietary patterns: the NUTRIDIET questionnaire. PG - 104264 LID - S0939-4753(25)00418-1 [pii] LID - 10.1016/j.numecd.2025.104264 [doi] AB - BACKGROUND AND AIMS: Unhealthy dietary patterns are a major contributor to non-communicable diseases. The Mediterranean Diet (MD) proved health benefits, but its adherence has declined in Italy. Nutrition knowledge (NK) significantly influences dietary behavior, but no validated tool exists to assess NK and perceptions of the MD and other dietary patterns. This study aimed to develop and validate the NUTRIDIET questionnaire among the Italian population. METHODS AND RESULTS: A prospective observational study was conducted on 438 Italian adults (18-65 years). The NUTRIDIET questionnaire consisted of 30 items across two sections: knowledge of dietary patterns and perceptions of their health impacts. The total score ranges 0-30 points. Reliability was assessed via internal consistency (Cronbach's alpha) and test-retest reliability. Construct validity was examined by comparing scores between participants with and without nutritional background. The questionnaire exhibited good internal consistency (Cronbach's alpha = 0.792) and test-retest reliability (R = 0.650, p < 0.001). Construct validity was confirmed by higher scores in participants with nutritional background (26.9 +/- 2.8) compared to those without (21.1 +/- 5.4, p < 0.001). Most items were of moderate difficulty and had a good discrimination index, distinguishing between individuals with different NK levels. CONCLUSION: The NUTRIDIET questionnaire is a valid and reliable tool for assessing NK and health-related perceptions of the MD and other diets in the Italian population, particularly among young adults and women. This instrument can aid in identifying knowledge gaps and programming targeted interventions to improve dietary adherence and public health outcomes. CI - Copyright (c) 2025 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Guglielmetti, Monica AU - Guglielmetti M AD - Human Nutrition Center, Department of Public Health, Experimental and Forensics Medicine, University of Pavia, Pavia, Italy; Working Group SINU Young of the Italian Society of Human Nutrition, Italy. FAU - Rosi, Alice AU - Rosi A AD - Working Group SINU Young of the Italian Society of Human Nutrition, Italy; Department of Food and Drug, University of Parma, Parma, Italy. FAU - Dinu, Monica AU - Dinu M AD - Working Group SINU Young of the Italian Society of Human Nutrition, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy. FAU - Fiorini, Simona AU - Fiorini S AD - Human Nutrition Center, Department of Public Health, Experimental and Forensics Medicine, University of Pavia, Pavia, Italy; Working Group SINU Young of the Italian Society of Human Nutrition, Italy. Electronic address: simona.fiorini@unipv.it. FAU - Martini, Daniela AU - Martini D AD - Working Group SINU Young of the Italian Society of Human Nutrition, Italy; Department of Food, Environmental, and Nutritional Sciences, University of Milan, Milan, Italy. FAU - Ferraris, Cinzia AU - Ferraris C AD - Human Nutrition Center, Department of Public Health, Experimental and Forensics Medicine, University of Pavia, Pavia, Italy; Working Group SINU Young of the Italian Society of Human Nutrition, Italy. CN - SINU Young Working Group of the Italian Society of Human Nutrition LA - eng PT - Journal Article PT - Observational Study PT - Validation Study DEP - 20250725 PL - Netherlands TA - Nutr Metab Cardiovasc Dis JT - Nutrition, metabolism, and cardiovascular diseases : NMCD JID - 9111474 SB - IM MH - Humans MH - *Diet, Mediterranean MH - Adult MH - Female MH - Middle Aged MH - Male MH - *Health Knowledge, Attitudes, Practice MH - Italy MH - Reproducibility of Results MH - Young Adult MH - *Diet, Healthy MH - Aged MH - Surveys and Questionnaires MH - Adolescent MH - Prospective Studies MH - Perception MH - Nutritional Status MH - Predictive Value of Tests MH - *Feeding Behavior OTO - NOTNLM OT - Dietary pattern OT - Healthy diets OT - Mediterranean diet OT - Nutrition knowledge OT - Questionnaire validation COIS- Declaration of competing interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/08/30 00:44 MHDA- 2025/12/18 01:31 CRDT- 2025/08/29 21:52 PHST- 2025/01/08 00:00 [received] PHST- 2025/06/28 00:00 [revised] PHST- 2025/07/21 00:00 [accepted] PHST- 2025/12/18 01:31 [medline] PHST- 2025/08/30 00:44 [pubmed] PHST- 2025/08/29 21:52 [entrez] AID - S0939-4753(25)00418-1 [pii] AID - 10.1016/j.numecd.2025.104264 [doi] PST - ppublish SO - Nutr Metab Cardiovasc Dis. 2026 Jan;36(1):104264. doi: 10.1016/j.numecd.2025.104264. Epub 2025 Jul 25. PMID- 40882841 OWN - NLM STAT- MEDLINE DCOM- 20251031 LR - 20260918 IS - 2589-9333 (Electronic) IS - 2589-9333 (Linking) VI - 7 IP - 11 DP - 2025 Nov TI - A Simple data-driven dietary pattern associated with lower risk for adverse pregnancy outcomes. PG - 101773 LID - S2589-9333(25)00172-7 [pii] LID - 10.1016/j.ajogmf.2025.101773 [doi] AB - BACKGROUND: Periconceptional diet has been associated with the risk of adverse pregnancy outcomes (APOs). Various types of diets have been studied to evaluate their potential protective effect against APOs. However, many of these diets are based on regional dietary preferences, are complex, and are composed of many different food categories. A simpler index may increase compliance and facilitate better clinical translation. OBJECTIVE: Evaluate whether alignment to a parsimonious index derived from periconceptional diet data is associated with reduced risk for APOs. DESIGN: We analyzed prospective data from 7,798 pregnant individuals from the USA in the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be (nuMoM2b) study. We applied a sparse regression model to data from food frequency questionnaires and used it to select a small number of food categories that were jointly associated with low risk. We validated this index internally in the nuMoM2b cohort and externally on similar data on 2,240 participants from the Environmental influences on Child Health Outcomes (ECHO) study. RESULTS: The data-driven dietary index (DDI) included legumes, citrus fruits, dark green vegetables, and whole grains as food categories associated with lower risk for APOs versus processed meats, potatoes, and refined grains as associated with higher risk. High alignment with the DDI was associated with 22% relative risk (RR) reduction for 1 or more APO (adjusted RR (aRR) [CI] of 0.78 [0.70,0.87]), preeclampsia (0.74 [0.56,0.99]), and gestational hypertension (0.81 [0.67,0.98]). Validation in the ECHO dataset showed that high alignment to the DDI was associated with a 31% reduction in APOs (crude RR of 0.69 [0.50,0.89]). CONCLUSIONS: We demonstrated an approach for devising a simple data-driven dietary index, showed that it is associated with reduced APO risk when accounting for confounders, and validated it in an independent dataset. Future studies could validate the DDI for prospective interventions, as well as apply our approach to other populations or clinical settings. CI - Copyright (c) 2025 Elsevier Inc. All rights reserved. FAU - Batuure, Andrew AU - Batuure A AD - Program for Mathematical Genomics, Department of Systems Biology, Columbia University Irving Medical Center, New York, NY (Batuure, Austin, Brown Kav and Korem); Institute of Human Nutrition, Vagelos College of Physician and Scientists, Columbia University Irving Medical center, New York, NY (Batuure). FAU - Austin, George I AU - Austin GI AD - Program for Mathematical Genomics, Department of Systems Biology, Columbia University Irving Medical Center, New York, NY (Batuure, Austin, Brown Kav and Korem); Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY (Austin). FAU - Grobman, William A AU - Grobman WA AD - Department of Obstetrics and Gynecology, Brown University, Providence, RI (Grobman). FAU - Lindsay, Karen L AU - Lindsay KL AD - Department of Pediatrics, UCI School of Medicine, University of California Irvine, Orange, CA (Lindsay); UCI Susan Samueli Integrative Health Institute, Susan & Henry Samueli College of Health Sciences, University of California Irvine, Irvine, CA (Lindsay). FAU - Haas, David M AU - Haas DM AD - Department of Obstetrics and Gynecology, Indiana University, Indianapolis, IN (Haas). FAU - Parry, Samuel AU - Parry S AD - Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA (Parry). FAU - Saade, George R AU - Saade GR AD - Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, VA (Saade). FAU - Simhan, Hyagriv N AU - Simhan HN AD - Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, (Simhan). FAU - Silver, Robert M AU - Silver RM AD - Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT (Silver). FAU - Reddy, Uma M AU - Reddy UM AD - Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY (Reddy and Korem). FAU - Brown Kav, Aya AU - Brown Kav A AD - Program for Mathematical Genomics, Department of Systems Biology, Columbia University Irving Medical Center, New York, NY (Batuure, Austin, Brown Kav and Korem). FAU - Wang, Shuang AU - Wang S AD - Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY (Wang). FAU - Bello, Natalie A AU - Bello NA AD - Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (Bello). FAU - Korem, Tal AU - Korem T AD - Program for Mathematical Genomics, Department of Systems Biology, Columbia University Irving Medical Center, New York, NY (Batuure, Austin, Brown Kav and Korem); Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY (Reddy and Korem). Electronic address: tal.korem@columbia.edu. LA - eng GR - UH3 OD023286/OD/NIH HHS/United States GR - UH3 OD023271/OD/NIH HHS/United States GR - UH3 OD023282/OD/NIH HHS/United States GR - UH3 OD023287/OD/NIH HHS/United States GR - U24 OD023319/OD/NIH HHS/United States GR - UH3 OD023305/OD/NIH HHS/United States GR - R01 HD106017/HD/NICHD NIH HHS/United States GR - UH3 OD023288/OD/NIH HHS/United States GR - UH3 OD023342/OD/NIH HHS/United States GR - U10 HD063053/HD/NICHD NIH HHS/United States GR - UH3 OD023268/OD/NIH HHS/United States GR - UH3 OD023337/OD/NIH HHS/United States GR - UH3 OD023328/OD/NIH HHS/United States GR - U2C ES026533/ES/NIEHS NIH HHS/United States GR - U24 OD023382/OD/NIH HHS/United States GR - UH3 OD023313/OD/NIH HHS/United States GR - U2C ES026544/ES/NIEHS NIH HHS/United States GR - UH3 OD023289/OD/NIH HHS/United States GR - UH3 OD023332/OD/NIH HHS/United States GR - U2C ES026542/ES/NIEHS NIH HHS/United States GR - U2C ES026555/ES/NIEHS NIH HHS/United States GR - U2C ES030857/ES/NIEHS NIH HHS/United States GR - U2C ES026561/ES/NIEHS NIH HHS/United States GR - UH3 OD023249/OD/NIH HHS/United States GR - UH3 OD023389/OD/NIH HHS/United States GR - U10 HD063036/HD/NICHD NIH HHS/United States GR - UH3 OD023290/OD/NIH HHS/United States GR - U2C OD023375/OD/NIH HHS/United States GR - U10 HD063046/HD/NICHD NIH HHS/United States GR - U10 HD063072/HD/NICHD NIH HHS/United States GR - U24 ES026539/ES/NIEHS NIH HHS/United States GR - UH3 OD023285/OD/NIH HHS/United States GR - UH3 OD023344/OD/NIH HHS/United States GR - U10 HD063037/HD/NICHD NIH HHS/United States GR - UH3 OD023275/OD/NIH HHS/United States GR - UH3 OD023318/OD/NIH HHS/United States GR - UH3 OD023348/OD/NIH HHS/United States GR - U10 HD063048/HD/NICHD NIH HHS/United States GR - U10 HD063047/HD/NICHD NIH HHS/United States GR - UH3 OD023248/OD/NIH HHS/United States GR - UL1 TR001108/TR/NCATS NIH HHS/United States GR - UH3 OD023253/OD/NIH HHS/United States GR - UH3 OD023272/OD/NIH HHS/United States GR - UH3 OD023347/OD/NIH HHS/United States GR - U10 HD063041/HD/NICHD NIH HHS/United States GR - U10 HD063020/HD/NICHD NIH HHS/United States GR - UL1 TR000153/TR/NCATS NIH HHS/United States GR - R01 HD114715/HD/NICHD NIH HHS/United States GR - UH3 OD023251/OD/NIH HHS/United States GR - UH3 OD023279/OD/NIH HHS/United States GR - UH3 OD023244/OD/NIH HHS/United States GR - UH3 OD023320/OD/NIH HHS/United States GR - UH3 OD023349/OD/NIH HHS/United States GR - UH3 OD023365/OD/NIH HHS/United States PT - Journal Article DEP - 20250827 PL - United States TA - Am J Obstet Gynecol MFM JT - American journal of obstetrics & gynecology MFM JID - 101746609 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Adult MH - *Pregnancy Outcome/epidemiology MH - Prospective Studies MH - *Diet/statistics & numerical data MH - *Pregnancy Complications/epidemiology/prevention & control MH - United States/epidemiology MH - *Feeding Behavior PMC - PMC12619569 MID - NIHMS2107730 OTO - NOTNLM OT - adverse pregnancy outcomes OT - diet OT - dietary index OT - periconceptional diet OT - preeclampsia OT - preterm birth COIS- Declaration of competing interest The authors report no conflict of interests. EDAT- 2025/08/30 00:44 MHDA- 2025/11/01 05:37 PMCR- 2026/07/16 CRDT- 2025/08/29 19:13 PHST- 2025/06/01 00:00 [received] PHST- 2025/07/29 00:00 [revised] PHST- 2025/08/05 00:00 [accepted] PHST- 2025/11/01 05:37 [medline] PHST- 2025/08/30 00:44 [pubmed] PHST- 2025/08/29 19:13 [entrez] PHST- 2026/07/16 00:00 [pmc-release] AID - S2589-9333(25)00172-7 [pii] AID - 10.1016/j.ajogmf.2025.101773 [doi] PST - ppublish SO - Am J Obstet Gynecol MFM. 2025 Nov;7(11):101773. doi: 10.1016/j.ajogmf.2025.101773. Epub 2025 Aug 27. PMID- 40882656 OWN - NLM STAT- MEDLINE DCOM- 20251127 LR - 20251206 IS - 2213-2619 (Electronic) IS - 2213-2600 (Print) IS - 2213-2600 (Linking) VI - 13 IP - 12 DP - 2025 Dec TI - Projecting the 30-year burden of obstructive sleep apnoea in the USA: a prospective modelling study. PG - 1078-1086 LID - S2213-2600(25)00243-7 [pii] LID - 10.1016/S2213-2600(25)00243-7 [doi] AB - BACKGROUND: Obstructive sleep apnoea is a common disorder that is associated with major public health and economic burden across the USA. Previous studies have assessed the prevalence of the condition. In the present study, we aimed to estimate the burden of obstructive sleep apnoea across the USA from 2020 to 2050, to guide public health policies and management pathways. METHODS: In this prospective modelling study, historical data on obstructive sleep apnoea prevalence in the USA were extracted from a previously published longitudinal cohort study. US population characteristics (age and sex) were obtained from relevant and validated population data sources, and data on BMI were obtained from the National Health and Nutrition Examination Survey and the Wisconsin Sleep Cohort. To project the obstructive sleep apnoea burden (cases and prevalence) into 2050, we developed an open cohort dynamic population simulation model. FINDINGS: On the basis of projected changes in US age, sex, and BMI population distributions, the model predicts a significant rise in obstructive sleep apnoea over the next three decades. By 2050, the prevalence of obstructive sleep apnoea (apnoea-hypopnoea index >/=5/h) is expected to show a relative increase of 34.7%, from 34.3% (95% uncertainty interval [UI] 34.0-34.4) to 46.2% (46.0-46.4), resulting in 76.6 million cases. We estimate that females will see a larger relative increase than males, with a 65.4% relative increase in prevalence, from 22.8% (22.5-23.0) to 37.7% (37.4-38.0) reaching a total of 30.4 million cases. Males are projected to show a more moderate relative increase of 19.3%, from 45.6% (45.4-46.0) to 54.4% (54.2-54.7), reaching 45.9 million cases. INTERPRETATION: Projections indicate that obstructive sleep apnoea will affect 76.6 million adults aged 30-69 years across the USA in 2050, with a disproportionate growth among females compared with males. These findings highlight the urgent need for targeted public health strategies and revised access to diagnosis and follow-up pathways to address the growing prevalence of obstructive sleep apnoea, particularly among females. FUNDING: Resmed. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved, including those for text and data mining, AI training, and similar technologies. FAU - Boers, Elroy AU - Boers E AD - Resmed Science Center, San Diego California, San Diego, CA, USA. Electronic address: Elroy.Boers@Resmed.com. FAU - Barrett, Meredith A AU - Barrett MA AD - Resmed Science Center, San Diego California, San Diego, CA, USA. FAU - Benjafield, Adam V AU - Benjafield AV AD - Resmed Science Center, San Diego California, San Diego, CA, USA. FAU - Barnet, Jodi H AU - Barnet JH AD - University of Wisconsin-Madison, Wisconsin, MA, USA. FAU - Ravelo, Laurel A AU - Ravelo LA AD - University of Wisconsin-Madison, Wisconsin, MA, USA. FAU - Kaye, Leanne AU - Kaye L AD - Resmed Science Center, San Diego California, San Diego, CA, USA. FAU - Cistulli, Peter A AU - Cistulli PA AD - Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia; Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, Cammeray, NSW, Australia. FAU - Pepin, Jean-Louis AU - Pepin JL AD - HP2 Laboratory, Inserm U1300, Grenoble Alpes University, Grenoble, France. FAU - Armitstead, Jeff AU - Armitstead J AD - Resmed Science Center, San Diego California, San Diego, CA, USA. FAU - Sterling, Kimberly L AU - Sterling KL AD - Resmed Science Center, San Diego California, San Diego, CA, USA. FAU - Nunez, Carlos M AU - Nunez CM AD - Resmed Science Center, San Diego California, San Diego, CA, USA. FAU - Peppard, Paul E AU - Peppard PE AD - University of Wisconsin-Madison, Wisconsin, MA, USA. FAU - Malhotra, Atul AU - Malhotra A AD - University of California, La Jolla, CA, USA. LA - eng GR - R01 HL157985/HL/NHLBI NIH HHS/United States GR - T32 HL166127/HL/NHLBI NIH HHS/United States GR - R01 HL166485/HL/NHLBI NIH HHS/United States GR - R01 AG063925/AG/NIA NIH HHS/United States GR - R01 HL154926/HL/NHLBI NIH HHS/United States GR - R01 HL148436/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20250826 PL - England TA - Lancet Respir Med JT - The Lancet. Respiratory medicine JID - 101605555 SB - IM MH - Humans MH - *Sleep Apnea, Obstructive/epidemiology MH - Male MH - Female MH - United States/epidemiology MH - Middle Aged MH - Prospective Studies MH - Adult MH - Prevalence MH - Aged MH - Body Mass Index MH - *Cost of Illness MH - Young Adult MH - Adolescent MH - Nutrition Surveys MH - Longitudinal Studies MH - Forecasting PMC - PMC12674968 MID - NIHMS2108361 COIS- Declaration of interests EB, MAB, AVB, LK, JA, KLS, and CMN are employees of Resmed. PAC reports having an appointment to an endowed academic Chair at the University of Sydney that was established from Resmed funding, has received research support from Resmed and SomnoMed, and is a consultant to Resmed, SomnoMed, Sunrise Medical, and Eli Lilly. J-LP is supported by the French National Research Agency in the framework of the Investissements d'Avenir program (ANR-15-IDEX-02) and the e-Health and Integrated Care and Trajectories Medicine and MIAI Artificial Intelligence chairs of excellence from the Grenoble Alpes University Foundation (ANR-19-P3IA-0003). J-LP also reports lecture fees or conference travel grants from Resmed, Philips, Jazz Pharmaceuticals, Agiradom, and Bioprojet. AM is funded by the National Institutes of Health and reports income related to medical education from LivaNova, Jazz Pharmaceuticals, ZOLL, and Eli Lilly. Resmed provided a philanthropic donation to University of California San Diego, San Diego, CA, USA, but AM has not received personal income from ResMed or medXcloud. All other authors declare no competing interests. EDAT- 2025/08/30 00:44 MHDA- 2025/11/28 00:26 PMCR- 2025/12/04 CRDT- 2025/08/29 18:52 PHST- 2025/04/14 00:00 [received] PHST- 2025/06/16 00:00 [revised] PHST- 2025/06/25 00:00 [accepted] PHST- 2025/11/28 00:26 [medline] PHST- 2025/08/30 00:44 [pubmed] PHST- 2025/08/29 18:52 [entrez] PHST- 2025/12/04 00:00 [pmc-release] AID - S2213-2600(25)00243-7 [pii] AID - 10.1016/S2213-2600(25)00243-7 [doi] PST - ppublish SO - Lancet Respir Med. 2025 Dec;13(12):1078-1086. doi: 10.1016/S2213-2600(25)00243-7. Epub 2025 Aug 26. PMID- 40873302 OWN - NLM STAT- MEDLINE DCOM- 20250828 LR - 20260915 IS - 1654-9880 (Electronic) IS - 1654-9716 (Print) IS - 1654-9880 (Linking) VI - 18 IP - 1 DP - 2025 Dec TI - Validation of the Child Development Card (KKA) as a growth and development tool for stunted and normal children in West Java, Indonesia. PG - 2547440 LID - 10.1080/16549716.2025.2547440 [doi] LID - 2547440 AB - BACKGROUND: Stunting remains a major public health issue in Indonesia, and the limitations of anthropometric measures highlight the need for alternative tools such as the Child Development Card (KKA). OBJECTIVES: This study aimed to determine the validity and reliability of the KKA as a tool to measure the growth and development of stunted and normal children through direct observation. METHODS: The revised KKA was administered to 262 children aged 13-60 months, including 174 normal and 88 stunted children, from three stunting-locus regencies in West Java Province, Indonesia. The data were analysed using content validity, the Guttman coefficient of reproducibility, and Cronbach alpha to develop a revised KKA observation guideline. RESULTS: A total of 15 conceptually inappropriate items were revised, and an observation guideline was developed as a guide for the direct observation of children. In each aspect of growth and development, age range, and sample category, the reproducibility and scalability coefficients showed values of >0.9 and >0.6, respectively. Meanwhile, Cronbach alpha values for each age range and sample category were >0.7. CONCLUSION: The revised KKA demonstrated both validity and reliability as a tool for the detection, monitoring, and early intervention of growth and developmental delays in children with stunted as well as those with normal development. FAU - Jatnika, Ratna AU - Jatnika R AUID- ORCID: 0000-0002-7519-4968 AD - Department of Psychology, Faculty of Psychology, Universitas Padjadjaran, Sumedang, Bandung, Indonesia. AD - Center for Psychometrics Study, Faculty of Psychology, Universitas Padjadjaran, Sumedang, Bandung, Indonesia. FAU - Agustiani, Hendriati AU - Agustiani H AUID- ORCID: 0000-0003-2360-0474 AD - Department of Psychology, Faculty of Psychology, Universitas Padjadjaran, Sumedang, Bandung, Indonesia. FAU - Syahlaa, Syauqiyyah AU - Syahlaa S AUID- ORCID: 0009-0005-2085-6513 AD - Department of Psychology, Faculty of Psychology, Universitas Padjadjaran, Sumedang, Bandung, Indonesia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250828 PL - United States TA - Glob Health Action JT - Global health action JID - 101496665 SB - IM MH - Humans MH - Indonesia/epidemiology MH - Infant MH - *Growth Disorders/diagnosis MH - Male MH - Female MH - Child, Preschool MH - *Child Development MH - Reproducibility of Results MH - Anthropometry/methods PMC - PMC12395626 OAB - Main findings: Developed a direct observation-based tool for assessing child development in both stunted and normal children.Added knowledge: Provided psychometric properties for a community-based developmental assessment tool tailored to the Indonesian context.Global health impact for policy and action: Offers a low-cost, comprehensive developmental assessment using simple household items, making it feasible for implementation in high-stunting prevalence areas. OABL- eng OTO - NOTNLM OT - Child development card (KKA) OT - Guttman coefficient OT - Indonesia OT - cronbach alpha OT - psychometric properties OT - stunted COIS- No potential conflict of interest was reported by the author(s). EDAT- 2025/08/30 04:46 MHDA- 2025/08/30 04:47 PMCR- 2025/08/28 CRDT- 2025/08/28 03:32 PHST- 2025/08/30 04:47 [medline] PHST- 2025/08/30 04:46 [pubmed] PHST- 2025/08/28 03:32 [entrez] PHST- 2025/08/28 00:00 [pmc-release] AID - 2547440 [pii] AID - 10.1080/16549716.2025.2547440 [doi] PST - ppublish SO - Glob Health Action. 2025 Dec;18(1):2547440. doi: 10.1080/16549716.2025.2547440. Epub 2025 Aug 28. PMID- 40871732 OWN - NLM STAT- MEDLINE DCOM- 20250828 LR - 20250831 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 16 DP - 2025 Aug 21 TI - Adaptation of the Child Coeliac Disease Food Attitudes and Behaviours Scale (Child CD-FAB) into Brazilian Portuguese: Translation and Evaluation of Reproducibility and Internal Consistency. LID - 10.3390/nu17162704 [doi] LID - 2704 AB - Background/Objectives: This study aimed to translate the Child Coeliac Disease Food Attitudes and Behaviours Scale (Child CD-FAB) into Brazilian Portuguese and to evaluate its reproducibility and internal consistency. Methods: Three steps were carried out: (i) translation and cultural adaptation of the Child CD-FAB into Brazilian Portuguese; (ii) pre-test; and (iii) psychometric evaluation of the Child CD-FAB-BR. The Child CD-FAB was translated and back-translated, and then discussed with and approved by the author of the original instrument. The translated version was tested on five children and adolescents (aged 8 to 16 years) with coeliac disease to assess comprehension. Subsequently, psychometric evaluation used responses from 20 participants with the same characteristics, assessing reproducibility (test-retest reliability) via intraclass correlation coefficient (ICC) and internal consistency via Cronbach's alpha. Results: The Child CD-FAB was successfully translated to Brazilian Portuguese (Child CD-FAB-BR), and it presented good internal consistency (alpha = 0.892) and an excellent intraclass correlation coefficient (ICC = 0.923). Conclusions: The Child CD-FAB-BR is the first instrument to evaluate food attitudes and behaviours in Brazilian children and adolescents with CD, showing good psychometric properties. This instrument will support future research and clinical practice by guiding behaviour-based strategies to enhance nutritional education and public policies for this group. FAU - Schwantes, Marina de Cesaro AU - Schwantes MC AD - Department of Nutrition, Faculty of Health Sciences, Darcy Ribeiro University Campus, University of Brasilia, Brasilia 70910-900, Distrito Federal, Brazil. FAU - Maddison-Roberts, Heather AU - Maddison-Roberts H AD - South West London & St George's Mental Health NHS Trust, London SW17 0YF, UK. FAU - Nakano, Eduardo Yoshio AU - Nakano EY AUID- ORCID: 0000-0002-9071-8512 AD - Department of Statistics, University of Brasilia, Brasilia 70910-900, Distrito Federal, Brazil. FAU - Botelho, Raquel Braz Assuncao AU - Botelho RBA AUID- ORCID: 0000-0002-0369-287X AD - Department of Nutrition, Faculty of Health Sciences, Darcy Ribeiro University Campus, University of Brasilia, Brasilia 70910-900, Distrito Federal, Brazil. FAU - Zandonadi, Renata Puppin AU - Zandonadi RP AUID- ORCID: 0000-0003-0370-3089 AD - Department of Nutrition, Faculty of Health Sciences, Darcy Ribeiro University Campus, University of Brasilia, Brasilia 70910-900, Distrito Federal, Brazil. LA - eng GR - Edital 003/2025/Fundacao de Apoio a Pesquisa do Distrito Federal (FAPDF)/ PT - Journal Article DEP - 20250821 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - Reproducibility of Results MH - Adolescent MH - Brazil MH - Female MH - Male MH - Psychometrics MH - *Celiac Disease/psychology/diet therapy MH - Translations MH - Surveys and Questionnaires MH - *Feeding Behavior MH - Translating MH - *Health Knowledge, Attitudes, Practice PMC - PMC12389570 OTO - NOTNLM OT - eating attitudes OT - eating behaviours OT - gluten-free diet OT - hypervigilance around food OT - questionnaire COIS- The authors declare no conflicts of interest. EDAT- 2025/08/30 04:51 MHDA- 2025/08/30 04:52 PMCR- 2025/08/21 CRDT- 2025/08/28 01:21 PHST- 2025/07/21 00:00 [received] PHST- 2025/08/15 00:00 [revised] PHST- 2025/08/16 00:00 [accepted] PHST- 2025/08/30 04:52 [medline] PHST- 2025/08/30 04:51 [pubmed] PHST- 2025/08/28 01:21 [entrez] PHST- 2025/08/21 00:00 [pmc-release] AID - nu17162704 [pii] AID - nutrients-17-02704 [pii] AID - 10.3390/nu17162704 [doi] PST - epublish SO - Nutrients. 2025 Aug 21;17(16):2704. doi: 10.3390/nu17162704. PMID- 40871664 OWN - NLM STAT- MEDLINE DCOM- 20250828 LR - 20250831 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 16 DP - 2025 Aug 14 TI - Validation of KIDMED 2.0 PL-Mediterranean Diet Quality Index for Polish Children and Adolescents. LID - 10.3390/nu17162636 [doi] LID - 2636 AB - BACKGROUND: The Mediterranean diet is widely recognised for its health benefits and remains a key reference point in shaping dietary guidelines across populations. Despite its growing international relevance, there is a lack of validated tools assessing Mediterranean diet adherence among children and adolescents in Central and Eastern Europe. METHODS: The present study aimed to adapt and validate the KIDMED 2.0 questionnaire for use in Polish children and adolescents aged 10 to 18 years (KIDMED 2.0 PL). The adaptation process involved forward-backward translation, expert consultations, and pilot testing to ensure linguistic and cultural relevance. A total of 102 participants completed the questionnaire twice over a two-week interval, and anthropometric data were collected. RESULTS: The KIDMED 2.0 PL demonstrated high test-retest reliability (Spearman's rho = 0.876; p < 0.001) and strong criterion validity, with a significant negative correlation between KIDMED scores and BMI centile (rho = -0.854; p < 0.001). Children with normal weight showed the highest adherence to the Mediterranean diet, while scores were significantly lower in overweight and obese participants. Item-level analysis indicated that fruit and vegetable consumption was relatively frequent, whereas intake of legumes, whole grains, and extra virgin olive oil remained low. CONCLUSIONS: The KIDMED 2.0 PL is a valid and reliable tool for evaluating diet quality and Mediterranean dietary adherence in the Polish pediatric population. FAU - Bober, Julia AU - Bober J AUID- ORCID: 0009-0003-4565-2512 AD - International Doctoral School, Medical University of Lodz, 90-647 Lodz, Poland. AD - Department of Nutrition and Epidemiology, Medical University of Lodz, 90-752 Lodz, Poland. FAU - Gaszynska, Ewelina AU - Gaszynska E AUID- ORCID: 0000-0001-7568-3502 AD - Department of Nutrition and Epidemiology, Medical University of Lodz, 90-752 Lodz, Poland. LA - eng PT - Journal Article PT - Validation Study DEP - 20250814 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Diet, Mediterranean/statistics & numerical data MH - Adolescent MH - Child MH - Poland MH - Female MH - Male MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - *Diet Surveys MH - Body Mass Index MH - Nutrition Assessment PMC - PMC12389672 OTO - NOTNLM OT - BMI OT - KIDMED OT - adolescents OT - children OT - eating behaviours OT - mediterranean diet OT - validation COIS- The authors declare no conflicts of interest. EDAT- 2025/08/30 04:50 MHDA- 2025/08/30 04:51 PMCR- 2025/08/14 CRDT- 2025/08/28 01:20 PHST- 2025/07/29 00:00 [received] PHST- 2025/08/08 00:00 [revised] PHST- 2025/08/13 00:00 [accepted] PHST- 2025/08/30 04:51 [medline] PHST- 2025/08/30 04:50 [pubmed] PHST- 2025/08/28 01:20 [entrez] PHST- 2025/08/14 00:00 [pmc-release] AID - nu17162636 [pii] AID - nutrients-17-02636 [pii] AID - 10.3390/nu17162636 [doi] PST - epublish SO - Nutrients. 2025 Aug 14;17(16):2636. doi: 10.3390/nu17162636. PMID- 40868644 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250914 LR - 20250914 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 13 IP - 16 DP - 2025 Aug 17 TI - Association Between Physical Activity, Quality of Life, Barriers to Physical Activity, and Mental Health in Chilean Adolescents: The MOV-ES Study. LID - 10.3390/healthcare13162028 [doi] LID - 2028 AB - OBJECTIVE: To analyze the association between physical activity, health-related quality of life (HRQoL), and perceived barriers to physical activity with the risk of symptoms of depression, anxiety, and stress in Chilean adolescents. METHOD: A quantitative, cross-sectional, descriptive-correlational study was conducted with a sample of 351 secondary school students (mean age = 15.75 +/- 1.47 years) from several educational institutions in the south-central region of Chile. Validated instruments were used to assess physical activity (PAQ-A), symptoms of mental health (DASS-21), HRQoL (Kidscreen-52), and the short scale of barriers to physical activity. For exploratory purposes, mental health outcomes were dichotomized based on standard cut-off scores, and binary logistic regression models were estimated to identify associated factors. RESULTS: Based on the binary categorization, a substantial proportion of students exceeded the risk thresholds for depressive (54.4%), anxiety (63%), and stress symptoms (42.2%). Across models, lower physical activity levels, reduced autonomy and weaker relationships with parents, and barriers related to self-concept and motivation were consistently associated with higher mental health risk. Additionally, passive commuting and the perceived school environment emerged as specific predictors of stress and depression risk, respectively. CONCLUSIONS: These findings suggest that individual and contextual factors linked to lifestyle behaviors and perceived social support may play a critical role in adolescent mental health, and could represent key targets for school-based interventions. FAU - Merellano-Navarro, Eugenio AU - Merellano-Navarro E AUID- ORCID: 0000-0002-1557-2285 AD - Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca 3530000, Chile. FAU - Pasten-Hernandez, Pablo AU - Pasten-Hernandez P AUID- ORCID: 0000-0001-6601-2897 AD - Centro Integral Educacion, Talca 3461380, Chile. FAU - Aristegui-Mondaca, Juan AU - Aristegui-Mondaca J AD - Master Program of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca 3530000, Chile. FAU - Moran-Toloza, Antonia AU - Moran-Toloza A AUID- ORCID: 0009-0006-3872-1729 AD - Master Program of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca 3530000, Chile. FAU - Nunez-Galaz, Marcelo AU - Nunez-Galaz M AUID- ORCID: 0000-0001-8809-9065 AD - Municipalidad de Lolol, Region del Libertador General Bernardo, O'Higgins 3140000, Chile. FAU - Giakoni-Ramirez, Frano AU - Giakoni-Ramirez F AUID- ORCID: 0000-0002-2685-8991 AD - Facultad de Educacion y Ciencias Sociales, Instituto del Deporte y Bienestar, Universidad Andres Bello, Santiago 7550000, Chile. FAU - Duclos-Bastias, Daniel AU - Duclos-Bastias D AUID- ORCID: 0000-0002-9020-5776 AD - Escuela de Educacion Fisica, Pontificia Universidad Catolica de Valparaiso, Valparaiso 2340000, Chile. FAU - Godoy-Cumillaf, Andres AU - Godoy-Cumillaf A AUID- ORCID: 0000-0001-8613-6838 AD - Grupo de Investigacion en Educacion Fisica, Salud y Calidad de Vida (EFISAL), Facultad de Educacion, Universidad Autonoma de Chile, Temuco 4780000, Chile. LA - eng GR - 11240343/National Research and Development Agency (in Spanish, ANID)/ PT - Journal Article DEP - 20250817 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12385419 OTO - NOTNLM OT - adolescents OT - health-related quality of life OT - mental health OT - physical activity COIS- The authors declare no conflict of interest. EDAT- 2025/08/30 04:46 MHDA- 2025/08/30 04:47 PMCR- 2025/08/17 CRDT- 2025/08/28 01:09 PHST- 2025/07/11 00:00 [received] PHST- 2025/08/07 00:00 [revised] PHST- 2025/08/14 00:00 [accepted] PHST- 2025/08/30 04:47 [medline] PHST- 2025/08/30 04:46 [pubmed] PHST- 2025/08/28 01:09 [entrez] PHST- 2025/08/17 00:00 [pmc-release] AID - healthcare13162028 [pii] AID - healthcare-13-02028 [pii] AID - 10.3390/healthcare13162028 [doi] PST - epublish SO - Healthcare (Basel). 2025 Aug 17;13(16):2028. doi: 10.3390/healthcare13162028. PMID- 40868534 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250914 LR - 20250914 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 8 DP - 2025 Aug 18 TI - Prediction of Children's Subjective Well-Being from Physical Activity and Sports Participation Using Machine Learning Techniques: Evidence from a Multinational Study. LID - 10.3390/children12081083 [doi] LID - 1083 AB - Background/Objectives: Traditional models like ordinary least squares (OLS) struggle to capture non-linear relationships in children's subjective well-being (SWB), which is associated with physical activity. This study evaluated machine learning (ML) for predicting SWB, focusing on sports participation, and explored theoretical prediction limits using a global dataset. It addresses a gap in understanding complex patterns across diverse cultural contexts. Methods: We analyzed 128,184 records from the ISCWeB survey (ages 6-14, 35 countries), with self-reported data on sports frequency, emotional states, and family support. To ensure cross-country generalizability, we used GroupKFold CV (grouped by country) and leave-one-country-out (LOCO) validation, yielding mean R(2) = 0.45 +/- 0.05, confirming robustness beyond cultural patterns, SHAP for interpretability, and bootstrapping for error estimation. No pre-registration was required for this secondary analysis. Results: XGBoost and LightGBM outperformed OLS, achieving R(2) up to 0.504 in restricted datasets (sensitivity excluding affective leakage: R(2) = 0.35), with sports-related variables (e.g., exercise frequency) associated positively with SWB predictions (SHAP values: +0.15-0.25; incremental DeltaR(2) = 0.06 over demographics/family/school base). Using test-retest reliability from literature (r = 0.74), the estimated irreducible RMSE reached 0.941; XGBoost achieved RMSE = 1.323, approaching the predictability bound with 68.1% of explainable variance captured (after noise adjustment). Partial dependence plots showed linear associations with exercise without satiation and slight age decline. Conclusions: ML improves SWB prediction in children, highlighting associations with sports participation, and approaches predictable variance bounds. These findings suggest potential for data-driven tools to identify patterns, such as through physical literacy pathways, informing physical activity interventions. However, longitudinal studies are needed to explore causality and address cultural biases in self-reports. FAU - de Souza-Lima, Josivaldo AU - de Souza-Lima J AUID- ORCID: 0000-0003-4372-0836 AD - Facultad de Educacion y Ciencias Sociales, Instituto del Deporte y Bienestar, Universidad Andres Bello, Las Condes, Santiago 7550000, Chile. AD - Facultad de Ciencias de la Educacion, Universidad de Granada, 18071 Granada, Spain. FAU - Ferrari, Gerson AU - Ferrari G AUID- ORCID: 0000-0003-3177-6576 AD - Escuela de Ciencias de la Actividad Fisica, el Deporte y la Salud, Universidad de Santiago de Chile (USACH), Santiago 7500618, Chile. FAU - Yanez-Sepulveda, Rodrigo AU - Yanez-Sepulveda R AUID- ORCID: 0000-0002-9311-6576 AD - Facultad de Educacion y Ciencias Sociales, Instituto del Deporte y Bienestar, Universidad Andres Bello, Las Condes, Santiago 7550000, Chile. FAU - Giakoni-Ramirez, Frano AU - Giakoni-Ramirez F AUID- ORCID: 0000-0002-2685-8991 AD - Facultad de Educacion y Ciencias Sociales, Instituto del Deporte y Bienestar, Universidad Andres Bello, Las Condes, Santiago 7550000, Chile. FAU - Munoz-Strale, Catalina AU - Munoz-Strale C AUID- ORCID: 0009-0002-5354-1313 AD - Facultad de Educacion y Ciencias Sociales, Instituto del Deporte y Bienestar, Universidad Andres Bello, Las Condes, Santiago 7550000, Chile. FAU - Alarcon-Aguilar, Javiera AU - Alarcon-Aguilar J AUID- ORCID: 0000-0003-4267-046X AD - Facultad de Educacion y Ciencias Sociales, Instituto del Deporte y Bienestar, Universidad Andres Bello, Las Condes, Santiago 7550000, Chile. FAU - Parra-Saldias, Maribel AU - Parra-Saldias M AD - Departamento de Educacion Fisica, Deporte y Recreacion, Universidad de Atacama, Copiapo 1530000, Chile. FAU - Duclos-Bastias, Daniel AU - Duclos-Bastias D AUID- ORCID: 0000-0002-9020-5776 AD - GEO Research Group, Escuela de Educacion Fisica, Pontificia Universidad Catolica de Valparaiso, Valparaiso 2362807, Chile. FAU - Godoy-Cumillaf, Andres AU - Godoy-Cumillaf A AUID- ORCID: 0000-0001-8613-6838 AD - Grupo de Investigacion en Educacion Fisica, Salud y Calidad de Vida (EFISAL), Facultad de Educacion, Universidad Autonoma de Chile, Temuco 4780000, Chile. FAU - Merellano-Navarro, Eugenio AU - Merellano-Navarro E AUID- ORCID: 0000-0002-1557-2285 AD - Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca 3530000, Chile. FAU - Bruneau-Chavez, Jose AU - Bruneau-Chavez J AUID- ORCID: 0009-0007-0149-796X AD - Departamento de Educacion Fisica, Deportes y Recreacion, Universidad de la Frontera, Temuco 4811230, Chile. FAU - Valdivia-Moral, Pedro AU - Valdivia-Moral P AUID- ORCID: 0000-0002-1905-3247 AD - Facultad de Ciencias de la Educacion, Universidad de Granada, 18071 Granada, Spain. LA - eng PT - Journal Article DEP - 20250818 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12384226 OTO - NOTNLM OT - SHAP OT - XGBoost OT - children OT - machine learning OT - physical activity OT - physical literacy OT - sports participation OT - subjective well-being COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2025/08/30 04:49 MHDA- 2025/08/30 04:50 PMCR- 2025/08/18 CRDT- 2025/08/28 01:08 PHST- 2025/07/29 00:00 [received] PHST- 2025/08/13 00:00 [revised] PHST- 2025/08/15 00:00 [accepted] PHST- 2025/08/30 04:50 [medline] PHST- 2025/08/30 04:49 [pubmed] PHST- 2025/08/28 01:08 [entrez] PHST- 2025/08/18 00:00 [pmc-release] AID - children12081083 [pii] AID - children-12-01083 [pii] AID - 10.3390/children12081083 [doi] PST - epublish SO - Children (Basel). 2025 Aug 18;12(8):1083. doi: 10.3390/children12081083. PMID- 40868430 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250914 LR - 20250914 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 8 DP - 2025 Jul 25 TI - Literacy or Useless Knowledge? Associations Between Health Literacy and Lifestyle Among Adolescents. LID - 10.3390/children12080978 [doi] LID - 978 AB - Background/Objectives: Health literacy plays a fundamental role in adolescents' health-related decisions and behaviors. The aim of our study was to assess the level of health literacy among 16-17-year-old students in Southern Hungary and to examine the associations between sociodemographic characteristics and health behaviors. Methods: This cross-sectional quantitative study was conducted in the autumn of 2024 in Baranya and Somogy counties. A total of 133 students completed a self-administered questionnaire including sociodemographic variables and health behaviors. Health literacy was measured using the validated HELMA-H instrument. Statistical analysis included chi-square tests, t-tests, and ANOVA (p < 0.05). Results: Overall, 62.7% of the students demonstrated adequate, while 37.3% demonstrated inadequate levels of health literacy. No significant association was found between overall health literacy and sociodemographic variables; however, partial associations were observed on specific subscales. Boys reported better access to health information (p = 0.037), while children of mothers with higher educational attainment scored better in comprehension (p = 0.042) and appraisal (p = 0.036). In the case of the numeracy subscale, children of mothers with the lowest educational level showed significantly better results (p = 0.006). Students with higher health literacy levels were less likely to smoke or consume caffeine; however, a reverse trend was observed regarding alcohol consumption. Physical activity showed a positive association with healthier behaviors (p < 0.05). Discussion: The use of digital technologies, interactive learning strategies, and the involvement of family members-especially mothers-may support the development of health-conscious decision-making in adolescents. Consequently, health education programs should focus not only on knowledge transfer but also on fostering critical thinking and decision-making skills. FAU - Varga, Bernadett AU - Varga B AUID- ORCID: 0000-0002-1990-5905 AD - Faculty of Health Sciences, Institute of Basics of Health Sciences, Midwifery and Health Visiting, University of Pecs, H-7621 Pecs, Hungary. FAU - Stromajer, Gabor Pal AU - Stromajer GP AUID- ORCID: 0009-0004-0473-1289 AD - Faculty of Health Sciences, Institute of Basics of Health Sciences, Midwifery and Health Visiting, University of Pecs, H-7621 Pecs, Hungary. AD - Institute of Education, Hungarian University of Agriculture and Life Sciences, H-7400 Kaposvar, Hungary. FAU - Heizler, Dora AU - Heizler D AD - Faculty of Health Sciences, Institute of Basics of Health Sciences, Midwifery and Health Visiting, University of Pecs, H-7621 Pecs, Hungary. FAU - Csima, Melinda AU - Csima M AUID- ORCID: 0000-0001-8361-6385 AD - Institute of Education, Hungarian University of Agriculture and Life Sciences, H-7400 Kaposvar, Hungary. FAU - Stromajer-Racz, Timea AU - Stromajer-Racz T AUID- ORCID: 0009-0005-3860-1420 AD - Institute of Diagnostic, Faculty of Health Sciences, University of Pecs, H-7621 Pecs, Hungary. LA - eng PT - Journal Article DEP - 20250725 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12384964 OTO - NOTNLM OT - adolescents OT - health behavior OT - health comprehension OT - health literacy COIS- The authors declare no conflicts of interest. EDAT- 2025/08/30 04:45 MHDA- 2025/08/30 04:46 PMCR- 2025/07/25 CRDT- 2025/08/28 01:08 PHST- 2025/06/19 00:00 [received] PHST- 2025/07/11 00:00 [revised] PHST- 2025/07/23 00:00 [accepted] PHST- 2025/08/30 04:46 [medline] PHST- 2025/08/30 04:45 [pubmed] PHST- 2025/08/28 01:08 [entrez] PHST- 2025/07/25 00:00 [pmc-release] AID - children12080978 [pii] AID - children-12-00978 [pii] AID - 10.3390/children12080978 [doi] PST - epublish SO - Children (Basel). 2025 Jul 25;12(8):978. doi: 10.3390/children12080978. PMID- 40867399 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250914 LR - 20250914 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 15 IP - 8 DP - 2025 Jul 31 TI - Validity of PROMIS((R)) Pediatric Physical Activity Parent Proxy Short Form Scale as a Physical Activity Measure for Children with Cerebral Palsy Who Are Non-Ambulatory. LID - 10.3390/bs15081042 [doi] LID - 1042 AB - Background: Self-report physical activity (PA) scales, accelerometry, and heart rate (HR) monitoring are reliable tools for PA measurement for children with cerebral palsy (CP); however, there are limitations for those who are primary wheelchair users. The purpose of our study was to evaluate face and construct validity of the PROMIS((R)) Pediatric PA parent proxy short form 8a in measuring PA amount and intensity in children with CP who are non-ambulatory. Methods: Face validity: Semi-structured interviews with parents and pediatric physical therapists (PTs) were conducted about the appropriateness of each item on the PROMIS((R)) Pediatric PA short form. Construct validity: Children with CP who were non-ambulatory participated in a one-week observational study. PA amount and intensity were examined using PA monitors (Actigraph GT9X) and HR monitors (Fitbit Charge 4). Activity counts and time in sedentary and non-sedentary intensity zones were derived and compared to the PROMIS((R)) T-scaled score. Results: Twenty-two physical therapists (PTs) and fifteen parents participated in the interviews, and ten children completed 1-week PA observation. Eight and seven participants completed sufficient time of uninterrupted PA and HR monitor wear, respectively. Parents and PTs agreed that several questions were not appropriate for children with CP who were non-ambulatory. PA intensity via activity counts derived from wrist worn monitors showed a strong positive correlation with the PROMIS((R)) PA measure. Conclusions: Construct validity in our small sample was established between PROMIS((R)) scores and accelerometry activity counts when documenting PA amount and intensity; however, there were some differences on PROMIS((R)) face validity per parent and PT respondents. Despite some concerns regarding face validity, the PROMIS((R)) Pediatric PA parent proxy short form 8a shows promise as a valid measure of physical activity amount and intensity in non-ambulatory children with CP, warranting further investigation and refinement. FAU - Toomer-Mensah, Nia AU - Toomer-Mensah N AD - Department of Biobehavioral Sciences, Teachers College, Columbia University, 520 W. 120th Street, Building 528 Room 1056A, New York, NY 10027, USA. AD - Doctor of Physical Therapy Program, Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Center, Aurora, CO 80045, USA. AD - Motor Development Laboratory, University of Southern California, Health Research Association, 1640 Marengo St. Suite 408, Los Angeles, CA 90033, USA. FAU - O'Neil, Margaret AU - O'Neil M AUID- ORCID: 0000-0003-0000-264X AD - Department of Physical Therapy and Kinesiology, Zuckerberg College of Health Sciences, University of Massachusetts, 113 Wilder Street, Suite 377, Lowell, MA 01854, USA. FAU - Quinn, Lori AU - Quinn L AUID- ORCID: 0000-0002-2982-923X AD - Department of Biobehavioral Sciences, Teachers College, Columbia University, 520 W. 120th Street, Building 528 Room 1056A, New York, NY 10027, USA. LA - eng GR - Mentored Research Grant/American Academy of Pediatric Physical Therapy/ PT - Journal Article DEP - 20250731 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC12382615 OTO - NOTNLM OT - Actigraph OT - FitBit OT - PROMIS(R) OT - accelerometers OT - cerebral palsy OT - heartrate OT - non-ambulatory OT - parents OT - physical activity OT - physical therapy OT - wearable-monitors COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2025/08/30 04:47 MHDA- 2025/08/30 04:48 PMCR- 2025/07/31 CRDT- 2025/08/28 01:03 PHST- 2025/03/13 00:00 [received] PHST- 2025/07/16 00:00 [revised] PHST- 2025/07/27 00:00 [accepted] PHST- 2025/08/30 04:48 [medline] PHST- 2025/08/30 04:47 [pubmed] PHST- 2025/08/28 01:03 [entrez] PHST- 2025/07/31 00:00 [pmc-release] AID - bs15081042 [pii] AID - behavsci-15-01042 [pii] AID - 10.3390/bs15081042 [doi] PST - epublish SO - Behav Sci (Basel). 2025 Jul 31;15(8):1042. doi: 10.3390/bs15081042. PMID- 40867383 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250914 LR - 20250914 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 15 IP - 8 DP - 2025 Jul 29 TI - Psychometric Properties of the Diabetes Eating Problem Survey-Revised in Arab Adolescents with Type 1 Diabetes: A Cross-Cultural Validation Study. LID - 10.3390/bs15081026 [doi] LID - 1026 AB - OBJECTIVES: The objective of this manuscript is to translate, adapt, and validate an Arabic version of the Diabetes Eating Problem Survey-Revised (DEPS-R) questionnaire to assess disordered eating behaviors (DEBs) in adolescents with T1D in Saudi Arabia. Additionally, the study sought to estimate the prevalence of DEBs and analyze its associations with glycemic control and diabetes-related complications. METHODS: A cross-cultural validation study was conducted following the COSMIN guidelines. The DEPS-R questionnaire was translated into Arabic through forward and backward translation involving expert panels, including psychiatrists, diabetologists, and linguists. A sample of 409 people with type 1 diabetes (PwT1D) (58.4% females) aged 12-20 years was recruited from outpatient diabetes clinics in the five main regions of Saudi Arabia. Participants completed the Arabic DEPS-R and the validated Arabic version of the SCOFF questionnaire. Sociodemographic, anthropometric, and biochemical data were collected, and statistical analyses, including confirmatory factor analysis (CFA) and internal consistency tests, were conducted. RESULTS: The Arabic DEPS-R exhibits strong internal consistency (Cronbach's alpha = 0.829) and high test-retest reliability (ICC = 0.861), with a CFA supporting a three-factor structure, namely body weight perception, disordered eating behaviors (DEBs), and bulimic tendencies. Notably, higher DEPS-R scores are significantly linked to elevated HbA1c levels, increased BMI, and more frequent insulin use. Alarmingly, 52.8% of participants show high-risk DEB, which is directly associated with poor glycemic control (HbA1c >/= 8.1%) and a heightened risk of diabetic ketoacidosis (DKA). CONCLUSIONS: The Arabic DEPS-R is a valid and reliable tool for screening DEBs among Saudi adolescents with T1D. Findings underscore the necessity for early identification and intervention to mitigate the impact of EDs on diabetes management and overall health outcomes. FAU - Alguwaihes, Abdullah M AU - Alguwaihes AM AUID- ORCID: 0000-0001-5800-9970 AD - Division of Endocrinology, Department of Internal Medicine, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia. AD - Diabetes Center, Dallah Hospital, Riyadh 12381, Saudi Arabia. FAU - Alenezi, Shuliweeh AU - Alenezi S AUID- ORCID: 0000-0002-7049-0960 AD - Department of Psychiatry, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia. AD - SABIC Psychological Health Research and Applications Chair (SPHRAC), Department of Psychiatry, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia. FAU - Almutawa, Renad AU - Almutawa R AUID- ORCID: 0000-0002-6930-047X AD - Department of Internal Medicine, King Fahad Medical City, Riyadh 11525, Saudi Arabia. FAU - Almutawa, Rema AU - Almutawa R AUID- ORCID: 0000-0002-9474-3408 AD - Department of Neurology, National Neurosciences Institute, King Fahad Medical City, Riyadh 11525, Saudi Arabia. FAU - Almusahel, Elaf AU - Almusahel E AUID- ORCID: 0009-0002-6289-7629 AD - Department of Neurology, National Neurosciences Institute, King Fahad Medical City, Riyadh 11525, Saudi Arabia. FAU - Alotaibi, Metib S AU - Alotaibi MS AUID- ORCID: 0000-0002-2051-8558 AD - University Diabetes Center, King Saud University Medical City, King Saud University, Riyadh 11472, Saudi Arabia. FAU - Al-Sofiani, Mohammed E AU - Al-Sofiani ME AUID- ORCID: 0000-0003-4420-9378 AD - Division of Endocrinology, Department of Internal Medicine, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia. FAU - AlSubaihin, Abdulmajeed AU - AlSubaihin A AUID- ORCID: 0000-0001-5736-0793 AD - Division of Endocrinology, Department of Pediatrics, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia. LA - eng PT - Journal Article DEP - 20250729 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC12383016 OTO - NOTNLM OT - DEPS-R OT - adolescents OT - cross-cultural validation OT - eating disorders OT - type 1 diabetes mellitus COIS- The authors declare no conflicts of interest. EDAT- 2025/08/30 04:49 MHDA- 2025/08/30 04:50 PMCR- 2025/07/29 CRDT- 2025/08/28 01:02 PHST- 2025/05/13 00:00 [received] PHST- 2025/07/17 00:00 [revised] PHST- 2025/07/25 00:00 [accepted] PHST- 2025/08/30 04:50 [medline] PHST- 2025/08/30 04:49 [pubmed] PHST- 2025/08/28 01:02 [entrez] PHST- 2025/07/29 00:00 [pmc-release] AID - bs15081026 [pii] AID - behavsci-15-01026 [pii] AID - 10.3390/bs15081026 [doi] PST - epublish SO - Behav Sci (Basel). 2025 Jul 29;15(8):1026. doi: 10.3390/bs15081026. PMID- 40864613 OWN - NLM STAT- MEDLINE DCOM- 20250828 LR - 20261022 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 8 DP - 2025 TI - From surviving to thriving: How sleep, physical activity, and diet shape well-being in young adults. PG - e0329689 LID - 10.1371/journal.pone.0329689 [doi] LID - e0329689 AB - Healthy lifestyles are a cornerstone of optimal physical health, yet their contribution to optimal mental health is still an open question. This article investigated the relationships between three key health behaviors-sleep quality, physical activity, and dietary choices-and psychological well-being among young adults ages 17-25, a demographic known for disproportionately low levels of well-being. The research used three datasets: a cross-sectional survey (Study 1, N = 1,032) and two daily diary datasets (Study 2, N = 818; Study 3, N = 236) of young adults living in New Zealand, the United Kingdom, and the United States. Multilevel regression analyses examined how these health behaviors simultaneously and synergistically predicted well-being at the between-person and within-person levels, while controlling for covariates such as age, gender, socioeconomic status, and depressive symptoms. Additionally, Study 3 incorporated wearable device-measured physical activity to supplement self-report measures. The findings highlighted better sleep quality as the strongest predictor of well-being across all three datasets, followed by fruit and vegetable consumption, with significant associations between these health behaviors and well-being observed at the between-person and within-person levels. Physical activity also emerged as a reliable predictor of well-being, mostly at the within-person level. The use of device-measured physical activity confirmed similar patterns, reinforcing the validity of findings. Pathways linking health behaviors to well-being were mostly additive, except for a buffering pattern observed at the within-person level indicating that higher fruit and vegetable intake could potentially mitigate the negative impact of poor sleep on daily well-being. This article underscores the importance of the "big three" health behaviors in well-being among young adults, offering insights for future health interventions to improve positive psychological functioning in this population. CI - Copyright: (c) 2025 Cooper et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Cooper, Jack R H AU - Cooper JRH AD - Department of Psychology, University of Otago, Dunedin, New Zealand. FAU - Turner, Robin S AU - Turner RS AD - Department of Preventative and Social Medicine, University of Otago, Dunedin, New Zealand. FAU - Conner, Tamlin S AU - Conner TS AUID- ORCID: 0000-0003-1520-5407 AD - Department of Psychology, University of Otago, Dunedin, New Zealand. LA - eng PT - Journal Article DEP - 20250827 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Male MH - Female MH - *Exercise/physiology MH - Young Adult MH - Adolescent MH - *Sleep/physiology MH - Adult MH - Cross-Sectional Studies MH - *Diet MH - United Kingdom MH - Health Behavior MH - Sleep Quality MH - New Zealand MH - United States MH - Mental Health PMC - PMC12385438 COIS- The authors have declared that no competing interests exist. EDAT- 2025/08/30 04:46 MHDA- 2025/08/30 04:47 PMCR- 2025/08/27 CRDT- 2025/08/27 13:22 PHST- 2025/01/06 00:00 [received] PHST- 2025/07/18 00:00 [accepted] PHST- 2025/08/30 04:47 [medline] PHST- 2025/08/30 04:46 [pubmed] PHST- 2025/08/27 13:22 [entrez] PHST- 2025/08/27 00:00 [pmc-release] AID - PONE-D-24-45325 [pii] AID - 10.1371/journal.pone.0329689 [doi] PST - epublish SO - PLoS One. 2025 Aug 27;20(8):e0329689. doi: 10.1371/journal.pone.0329689. eCollection 2025. PMID- 40882202 OWN - NLM STAT- MEDLINE DCOM- 20250829 LR - 20260811 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 14 DP - 2025 Aug 29 TI - Mindful Movement Programs in Community and University Preschools: Protocol for a Pilot Randomized Controlled Trial. PG - e75731 LID - 10.2196/75731 [doi] LID - e75731 AB - BACKGROUND: Chronic stress and emotional and cognitive regulation difficulties during early childhood are associated with risky behaviors and negative outcomes later in life. As preschoolers are at a developmental stage where their emotional and cognitive regulation skills are still emerging, they often rely on external support to manage their emotions and behaviors. Intervening early promotes healthy development and preventing adverse outcomes. Mindful movement practices (MMPs)-which incorporate physical activities, breathwork, and reflective exercises-show the potential to enhance emotional and behavioral skill regulation. However, the impact of MMPs on cognitive and social-emotional development in young children has not been thoroughly researched, and the underlying mechanisms remain unclear. OBJECTIVE: This pilot randomized controlled trial aims to assess the feasibility and acceptability of implementing MMPs in preschool classrooms and explore their effects on preschoolers' social-emotional, cognitive, and physiological development. The study also focuses on enhancing prosocial behaviors and reducing problem behaviors. This protocol paper outlines the research procedures, sample demographics, and survey data psychometric properties. METHODS: The study was conducted in 3 preschool classrooms (2 intervention and 1 waitlist control). Data were collected among 32 children and 8 teachers. Before the study began, 8 formative focus groups were facilitated with 5 administrators and 33 teachers in total to inform modifications to the program and research design. The intervention group participated in a 16-week program that included neural-based drills, aerobic activities, breathwork, and "feelings circle" exercises, along with classroom and home kits. The waitlist control group received a shortened 8-week program after the intervention groups completed their sessions. Data were collected before the intervention, at the midway point of the intervention, and after the intervention and again 2 months after the intervention. Measures included behavioral tasks, biomarkers (heart rate variability via wearable sensors and hormonal substrates in hair), and surveys from parents and teachers. Implementation fidelity was assessed using quantitative logs, qualitative field notes, and video observations. Postintervention interviews and focus groups were conducted with teachers, parents, and administrators. RESULTS: Formative focus groups were conducted with 33 teachers and 5 administrators. Behavioral task, biomarker, and survey data were collected from 40 participants, including 32 preschoolers aged 3 to 5 (mean 4.4, SD 0.64) years and 8 teachers with a mean age of 37.9 (SD 11.47) years. Postintervention interviews and focus groups were completed with 7 teachers, 4 administrators, and 8 parents. CONCLUSIONS: This paper describes study procedures. Future publications will present primary outcome findings and evaluate the feasibility and acceptability of this MMP and research design in community-based and university-based preschool settings. Future papers will explore the data to provide preliminary evidence for the program's effectiveness, mechanisms of effects, and the need for larger randomized controlled trials to optimize early childhood mindfulness interventions. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/75731. CI - (c)Jacinda K Dariotis, Dana A Eldreth, Rachel Jackson-Gordon, Hong Li, Kai-Ning Wang, Chunyuan Xi, Gregory F Lewis, Elizabeth A Shirtcliff. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 29.08.2025. FAU - Dariotis, Jacinda K AU - Dariotis JK AUID- ORCID: 0000-0002-3217-0392 AD - Department of Human Development and Family Studies, Family Resiliency Center, College of Agricultural, Consumer & Environmental Sciences, University of Illinois Urbana-Champaign, Urbana, IL, United States. AD - Department of Biomedical and Translational Sciences, Carle Illinois College of Medicine, University of Illinois Urbana-Champaign, Urbana, IL, United States. FAU - Eldreth, Dana A AU - Eldreth DA AUID- ORCID: 0000-0002-8392-0077 AD - Department of Human Development and Family Studies, Family Resiliency Center, College of Agricultural, Consumer & Environmental Sciences, University of Illinois Urbana-Champaign, Urbana, IL, United States. FAU - Jackson-Gordon, Rachel AU - Jackson-Gordon R AUID- ORCID: 0000-0002-9179-2140 AD - Department of Human Development and Family Studies, Family Resiliency Center, College of Agricultural, Consumer & Environmental Sciences, University of Illinois Urbana-Champaign, Urbana, IL, United States. FAU - Li, Hong AU - Li H AUID- ORCID: 0009-0000-9105-8838 AD - Department of Human Development and Family Studies, Family Resiliency Center, College of Agricultural, Consumer & Environmental Sciences, University of Illinois Urbana-Champaign, Urbana, IL, United States. FAU - Wang, Kai-Ning AU - Wang KN AUID- ORCID: 0009-0005-0623-4144 AD - Department of Human Development and Family Studies, Family Resiliency Center, College of Agricultural, Consumer & Environmental Sciences, University of Illinois Urbana-Champaign, Urbana, IL, United States. FAU - Xi, Chunyuan AU - Xi C AUID- ORCID: 0009-0006-1300-4934 AD - Department of Human Development and Family Studies, Family Resiliency Center, College of Agricultural, Consumer & Environmental Sciences, University of Illinois Urbana-Champaign, Urbana, IL, United States. FAU - Lewis, Gregory F AU - Lewis GF AUID- ORCID: 0000-0002-2548-8423 AD - Luddy School of Informatics, Computing, and Engineering, Indiana University Bloomington, Bloomington, IN, United States. FAU - Shirtcliff, Elizabeth A AU - Shirtcliff EA AUID- ORCID: 0000-0002-7097-9547 AD - Department of Psychology, College of Arts and Sciences, University of Oregon, Eugene, OR, United States. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20250829 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - Child, Preschool MH - Pilot Projects MH - *Mindfulness/methods MH - Female MH - Male MH - Universities MH - Child Development/physiology MH - Randomized Controlled Trials as Topic PMC - PMC12432471 OTO - NOTNLM OT - early childhood OT - emotional regulation OT - mindful movement practices OT - mindfulness OT - mindfulness-based intervention OT - preschool children OT - randomized controlled trial OT - social-emotional learning OT - stress response COIS- Conflicts of Interest: None declared. EDAT- 2025/08/29 20:45 MHDA- 2025/08/29 20:46 PMCR- 2025/08/29 CRDT- 2025/08/29 16:53 PHST- 2025/04/09 00:00 [received] PHST- 2025/05/29 00:00 [accepted] PHST- 2025/05/21 00:00 [revised] PHST- 2025/08/29 20:46 [medline] PHST- 2025/08/29 20:45 [pubmed] PHST- 2025/08/29 16:53 [entrez] PHST- 2025/08/29 00:00 [pmc-release] AID - v14i1e75731 [pii] AID - 10.2196/75731 [doi] PST - epublish SO - JMIR Res Protoc. 2025 Aug 29;14:e75731. doi: 10.2196/75731. PMID- 40880832 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250915 LR - 20250915 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 16 DP - 2025 TI - Exercise mediates the sex differences in adult visuospatial cognitive ability. PG - 1629724 LID - 10.3389/fpsyg.2025.1629724 [doi] LID - 1629724 AB - BACKGROUND: Sex differences in visuospatial cognitive performance have been consistently documented, with males typically demonstrating superior performance in tasks requiring spatial processing. While multiple biological, psychological, and sociocultural factors have been proposed to explain these differences, the role of physical exercise as a potential mediator remains understudied. Given that females typically engage in less physical exercise than males globally, this study aimed to investigate whether exercise intensity serves as a mediating factor in the observed sex/gender differences in visuospatial cognitive ability. METHODS: A total of 224 undergraduate students (112 men and 112 women) aged 18-25 years participated in a comprehensive battery of visuospatial cognitive tests, including assessments of mental rotation, spatial memory, and spatial navigation ability. Participants' weekly exercise patterns were assessed using the validated Godin-Shephard Leisure-Time Physical Activity Questionnaire, with activities categorized into strenuous, moderate, and mild exercise. Mediation analyses were conducted using the PROCESS macro (Model 4) with 5,000 bootstrap iterations, controlling for spatial anxiety, sense of direction, and childhood spatial activity experience. RESULTS: Males significantly outperformed females across all visuospatial cognitive domains (all p < 0.05). Mediation analysis revealed that leisure time activity score significantly mediated sex/gender differences in visuospatial cognitive ability, with indirect effects ranging from 20 to 34% of the total effect. When examining exercise intensity separately, strenuous exercise emerged as the primary mediator, particularly in mental rotation (indirect effect = 0.073, 95% CI [0.021, 0.134]) and spatial memory tests (forward span: indirect effect = 0.073, 95% CI [0.017, 0.147]; backward span: indirect effect = 0.069, 95% CI [0.009, 0.143]). The mediating effect of strenuous exercise was more pronounced in tasks with higher cognitive demands. CONCLUSION: Physical exercise, particularly strenuous exercise, partially mediates sex differences in visuospatial cognitive abilities among young adults. These findings suggest that promoting increased participation in strenuous physical activities among women may help reduce gender disparities in visuospatial cognition. However, the cross-sectional nature of this study precludes causal inferences, and future longitudinal or intervention studies are needed to confirm these relationships. CI - Copyright (c) 2025 Ruan, Hong, Huang, Yuan, Zhang, Mo, Hu and Liu. FAU - Ruan, Ruiqi AU - Ruan R AD - School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China. FAU - Hong, Junsheng AU - Hong J AD - Department of Otolaryngology, Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China. FAU - Huang, Yan AU - Huang Y AD - Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. FAU - Yuan, Fan AU - Yuan F AD - Department of Otolaryngology, Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China. FAU - Zhang, Xuehao AU - Zhang X AD - Department of Otolaryngology, Head and Neck Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Zhejiang, China. FAU - Mo, Yefei AU - Mo Y AD - Department of Otolaryngology, Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China. FAU - Hu, Tianxiao AU - Hu T AD - College of Life Science, Zhejiang Chinese Medical University, Hangzhou, China. AD - Department of Endocrinology, The 903rd Hospital of PLA, Hangzhou, China. FAU - Liu, Yuhe AU - Liu Y AD - Department of Otolaryngology, Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China. LA - eng PT - Journal Article DEP - 20250813 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC12380906 OTO - NOTNLM OT - exercise OT - gender differences OT - mental rotation OT - spatial memory OT - spatial navigation OT - visuospatial cognition COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/08/29 20:44 MHDA- 2025/08/29 20:45 PMCR- 2025/08/13 CRDT- 2025/08/29 14:17 PHST- 2025/05/16 00:00 [received] PHST- 2025/07/31 00:00 [accepted] PHST- 2025/08/29 20:45 [medline] PHST- 2025/08/29 20:44 [pubmed] PHST- 2025/08/29 14:17 [entrez] PHST- 2025/08/13 00:00 [pmc-release] AID - 10.3389/fpsyg.2025.1629724 [doi] PST - epublish SO - Front Psychol. 2025 Aug 13;16:1629724. doi: 10.3389/fpsyg.2025.1629724. eCollection 2025. PMID- 40879704 OWN - NLM STAT- Publisher LR - 20250829 IS - 1573-3327 (Electronic) IS - 0009-398X (Linking) DP - 2025 Aug 29 TI - Factor Structure and Measurement Invariance of the Farsi Version of the Nine-Item Avoidant/Restrictive Food Intake Disorder Screen (F-NIAS): Age, Sex, Weight, and Urbanization Group Differences in Disorder Risk Among Adolescents. LID - 10.1007/s10578-025-01906-3 [doi] AB - Avoidant/restrictive food intake disorder (ARFID) symptoms are prevalent among adolescents, yet no validated scale exists for Iran. This study evaluated the factor structure, measurement invariance, and prevalence of ARFID symptoms among adolescents at high risk for ARFID using the Farsi Nine-Item Avoidant/Restrictive Food Intake Disorder Screen (F-NIAS). Following translation and back-translation, 1,243 adolescents (75.9% girls) completed the F-NIAS. Confirmatory factor analysis confirmed the original three-factor structure with a good model fit. The scale demonstrated measurement invariance across sex, age, weight status, and residency, ensuring consistent performance across groups. Girls and younger adolescents showed higher ARFID symptoms than boys and older adolescents. Adolescents with average body mass index were more likely than those with higher weight to screen at high risk based on picky eating. Urban adolescents reported more low appetite-related restrictions. The F-NIAS is a valid scale for assessing ARFID symptoms in Iranian adolescents at risk for ARFID. CI - (c) 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Sahlan, Reza N AU - Sahlan RN AD - Department of Counseling, School, and Educational Psychology, Graduate School of Education, University at Buffalo-SUNY, Buffalo, NY, USA. FAU - Zickgraf, Hana AU - Zickgraf H AD - Research Center, Rogers Behavioral Health, 34700 Valley Rd, Oconomowoc, WI, 53066, USA. Hana.Zickgraf@rogersbh.org. FAU - D'Adamo, Laura AU - D'Adamo L AD - Department of Psychological and Brain Sciences, Drexel University, 3201 Chestnut St, Philadelphia, PA, 19104, USA. FAU - Saunders, Jessica F AU - Saunders JF AD - Division of General and Internal Medicine, Brigham and Women's Hospital, Boston, MA, USA. LA - eng GR - F31MH138068/MH/NIMH NIH HHS/United States PT - Journal Article DEP - 20250829 PL - United States TA - Child Psychiatry Hum Dev JT - Child psychiatry and human development JID - 1275332 SB - IM OTO - NOTNLM OT - Adolescents OT - Avoidant/restrictive food intake disorder OT - Prevalence OT - Validation COIS- Declarations. Conflict of interest: The authors declare no competing interests. Ethics approval: This study attained Institutional Review Board approval and complied with all ethical guidelines by a large university in Iran. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent: Parental consent was obtained for the adolescents who were interested in the study, and informed consent was obtained from the individual participants as well. EDAT- 2025/08/29 12:48 MHDA- 2025/08/29 12:48 CRDT- 2025/08/29 11:05 PHST- 2025/08/05 00:00 [accepted] PHST- 2025/08/29 12:48 [medline] PHST- 2025/08/29 12:48 [pubmed] PHST- 2025/08/29 11:05 [entrez] AID - 10.1007/s10578-025-01906-3 [pii] AID - 10.1007/s10578-025-01906-3 [doi] PST - aheadofprint SO - Child Psychiatry Hum Dev. 2025 Aug 29. doi: 10.1007/s10578-025-01906-3. PMID- 40877627 OWN - NLM STAT- MEDLINE DCOM- 20251007 LR - 20261010 IS - 1432-2218 (Electronic) IS - 0930-2794 (Linking) VI - 39 IP - 10 DP - 2025 Oct TI - Sixth international consensus conference on sleeve gastrectomy. PG - 6282-6288 LID - 10.1007/s00464-025-11974-0 [doi] AB - BACKGROUND: The aim of this consensus meeting and survey of international experts in obesity management was to establish a unified agreement on three key aspects of LSG: preoperative workup, intraoperative considerations, and the management of postoperative complications. METHODS: The content of this expert review was formulated and subjected to voting by a panel of leading specialists during the Sleeve Consensus Summit, held in Montpellier on 3rd and 4th of October 2024. Previous consensus conferences were analyzed to refine the questionnaires used in this study. RESULTS: A consensus rate above 70% among experts surveyed was reached for 35 out of 50 statements. The following indications for Sleeve Gastrectomy (SG) were endorsed: adolescent (<18 years old) surgery (92%), elderly (>65 years old) patients (94%), best surgical option for patients with severe liver disease (81%), for patients requiring liver, kidney or heart transplant (100%) and as the best option for patients requiring complex abdominal wall reconstruction (85%). Dissection of the hiatus should not be performed routinely (75% consensus) but small (<3 cm) hiatal hernia discovered during surgery should be directly repaired by cruroplasty (83% consensus). For the endoscopic management of acute leak post SG in stable patients, endoscopic pigtail drainage was judged as the best first-line option (82%), above stenting (29%) or endoscopic suturing (18%). RYGB was deemed indicated for patients with sufficient weight loss and severe GERD (76%) and SADI was judged as the best surgical option for patients with poor weight loss without severe GERD (70%). CONCLUSIONS: LSG has become a safe, efficient and validated procedure during the last 25 years. Both the preoperative workup and intraoperative considerations are well standardized. Our focus in clinical practice should be concentrated to diminish the reflux, but also to offer a better option for revisional surgery following LSG. CI - (c) 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Nocca, David AU - Nocca D AD - Digestive Surgery Department, Montpellier University Hospital, Montpellier, France. FAU - Gagner, Michel AU - Gagner M AD - Department of Surgery, Westmount Square Surgical Center, Westmount, Canada. FAU - Biertho, Laurent AU - Biertho L AD - Department of Metabolic and Bariatric Surgery, Institut Universitaire de cardiologie et pneumologie de Quebec - Universite Laval, Quebec, Canada. FAU - Cuenca-Abente, Federico AU - Cuenca-Abente F AD - Foregut Surgery Unit, Digestive Tract Surgery Service, Department of Surgery, Hospital de Gastroenterologia "Dr. Carlos Bonorino Udaondo", Ciudad Autonoma de Buenos Aires, Argentina. FAU - Nedelcu, Marius AU - Nedelcu M AD - ELSAN, Department of Bariatric Surgery, Bouchard Private Hospital, Marseille, France. nedelcu.marius@gmail.com. AD - Clinique Bouchard, 77 Rue de Dr. Escat, 13006, Marseille, France. nedelcu.marius@gmail.com. LA - eng PT - Consensus Statement PT - Journal Article DEP - 20250828 PL - Germany TA - Surg Endosc JT - Surgical endoscopy JID - 8806653 SB - IM MH - Humans MH - *Gastrectomy/methods/standards/adverse effects MH - *Postoperative Complications/etiology/therapy MH - *Bariatric Surgery/methods MH - *Obesity, Morbid/surgery MH - Laparoscopy/methods OTO - NOTNLM OT - Complication OT - Consensus OT - Obesity OT - Reflux OT - Sleeve EDAT- 2025/08/29 00:45 MHDA- 2025/10/07 06:30 CRDT- 2025/08/28 23:41 PHST- 2025/04/25 00:00 [received] PHST- 2025/06/25 00:00 [accepted] PHST- 2025/10/07 06:30 [medline] PHST- 2025/08/29 00:45 [pubmed] PHST- 2025/08/28 23:41 [entrez] AID - 10.1007/s00464-025-11974-0 [pii] AID - 10.1007/s00464-025-11974-0 [doi] PST - ppublish SO - Surg Endosc. 2025 Oct;39(10):6282-6288. doi: 10.1007/s00464-025-11974-0. Epub 2025 Aug 28. PMID- 40876385 OWN - NLM STAT- MEDLINE DCOM- 20251127 LR - 20260916 IS - 1873-7358 (Electronic) IS - 1471-0153 (Print) IS - 1471-0153 (Linking) VI - 59 DP - 2025 Dec TI - Evaluating the muscularity-oriented eating test: Factor structure and psychometric properties among university athletes and across sexes. PG - 102022 LID - S1471-0153(25)00087-X [pii] LID - 10.1016/j.eatbeh.2025.102022 [doi] AB - OBJECTIVE: The Muscularity-Oriented Eating Test (MOET) was developed to measure muscularity-oriented eating pathology among young men; however, this construct is relevant across sexes and may be particularly applicable to athletes. Thus, this study sought to validate the MOET among male and female athletes and non-athletes. METHODS: Students (N = 2189) from three U.S. universities completed an online survey. Confirmatory factor analyses (CFA) testing two MOET versions (12-items, 15-items) were conducted in male and female athletes and non-athletes. Chi-squared tests and invariance analyses were used to evaluate the fit of each model across groups. Convergent validity of the MOET was assessed with Spearman correlation tests. RESULTS: A one-factor CFA displayed adequate fit for 12-item and 15-item versions across all groups, except the 15-item version in the full sample. Chi-squared tests indicated superior fit of 12-item MOET CFAs among male and female athletes, female non-athletes, and all participants compared to 15-item models (adjusted p < .050); no difference in fit was evidenced between 12-item and 15-item CFAs for male non-athletes (adjusted p = .062). Both versions showed similar convergent validity. CONCLUSIONS: A 12-item MOET may provide improved screening for muscularity-oriented eating pathology in male and female athletes and female non-athletes. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - Hanss, Kaitlin AU - Hanss K AD - Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA. FAU - Denning, Dominic M AU - Denning DM AD - Department of Psychological and Brain Sciences, University of Massachusetts Amherst, MA, USA; Center for Advancement of Practices to End Suicide Through Technology, University of Massachusetts Chan Medical School, MA, USA. FAU - Flatt, Rachael E AU - Flatt RE AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. FAU - Sanzari, Christina M AU - Sanzari CM AD - Department of Psychology, University at Albany, State University of New York, Albany, NY, USA. FAU - Murray, Stuart B AU - Murray SB AD - Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA; Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. FAU - Lavender, Jason M AU - Lavender JM AD - Military Cardiovascular Outcomes Research Program (MiCOR), Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; The Metis Foundation, San Antonio, TX, USA. FAU - Compte, Emilio J AU - Compte EJ AD - Eating Behavior Research Center, School of Psychology, Universidad Adolfo Ibanez, Santiago, Chile; Research Department, Comenzar de Nuevo, Monterrey, Mexico. FAU - Blashill, Aaron J AU - Blashill AJ AD - San Diego State University/UC San Diego Joint Doctoral Program in Clinical Psychology, CA, USA; Department of Psychology, San Diego State University, CA, USA. FAU - Nagata, Jason M AU - Nagata JM AD - Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA. FAU - Keel, Pamela K AU - Keel PK AD - Department of Psychology, Florida State University, Tallahassee, FL, USA. FAU - Harriger, Jennifer AU - Harriger J AD - Social Science Division, Pepperdine University, Malibu, CA, USA. FAU - Nickols, Riley AU - Nickols R AD - Mind Body Endurance LLC, St. Louis, MO, USA. FAU - Mond, Jonathan AU - Mond J AD - Rural Clinical School, School of Medicine and Psychology, The Australian National University, Canberra, ACT, Australia; Centre for Rural Health, School of Health Sciences, University of Tasmania, Launceston, TAS, Australia; School of Medicine, Western Sydney University, Campbelltown, NSW, Australia. FAU - Brown, Tiffany A AU - Brown TA AD - Department of Psychological Sciences, Auburn University, Auburn, AL, USA. FAU - Gorrell, Sasha AU - Gorrell S AD - Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA. Electronic address: Sasha.Gorrell@ucsf.edu. LA - eng GR - K23 MH126201/MH/NIMH NIH HHS/United States GR - R21 MH131787/MH/NIMH NIH HHS/United States GR - R25 MH060482/MH/NIMH NIH HHS/United States GR - R61 MH133710/MH/NIMH NIH HHS/United States PT - Journal Article DEP - 20250815 PL - United States TA - Eat Behav JT - Eating behaviors JID - 101090048 SB - IM MH - Humans MH - Female MH - Male MH - *Athletes/psychology MH - Psychometrics MH - Universities MH - Young Adult MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Factor Analysis, Statistical MH - Reproducibility of Results MH - Students/psychology MH - *Body Image/psychology MH - Adolescent MH - Adult MH - Surveys and Questionnaires MH - *Feeding Behavior/psychology MH - Sex Factors PMC - PMC12413867 MID - NIHMS2108372 OTO - NOTNLM OT - Athletes OT - Drive for muscularity OT - Eating disorders OT - Muscularity-oriented disordered eating COIS- Declaration of competing interest All authors have no conflicts of interest to declare. EDAT- 2025/08/29 00:45 MHDA- 2025/11/28 00:26 PMCR- 2025/09/07 CRDT- 2025/08/28 18:10 PHST- 2025/03/05 00:00 [received] PHST- 2025/07/23 00:00 [revised] PHST- 2025/08/12 00:00 [accepted] PHST- 2025/11/28 00:26 [medline] PHST- 2025/08/29 00:45 [pubmed] PHST- 2025/08/28 18:10 [entrez] PHST- 2025/09/07 00:00 [pmc-release] AID - S1471-0153(25)00087-X [pii] AID - 10.1016/j.eatbeh.2025.102022 [doi] PST - ppublish SO - Eat Behav. 2025 Dec;59:102022. doi: 10.1016/j.eatbeh.2025.102022. Epub 2025 Aug 15. PMID- 40873767 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250831 IS - 0882-2689 (Print) IS - 1573-3505 (Electronic) IS - 0882-2689 (Linking) VI - 47 IP - 2 DP - 2025 Jun TI - Ecological Validity of Clinic-Based Actigraphy for Assessing Hyperactivity in Clinically Evaluated Children with and without ADHD. LID - 45 [pii] LID - 10.1007/s10862-025-10218-8 [doi] AB - Though often conflated with face validity, ecological validity refers to the degree that a test or measure predicts real-world behavior/functioning. The current study leveraged two independent samples to provide a critical evaluation of the extent to which clinic-based actigraphy demonstrates ecological validity evidence relative to parent- and teacher-reported hyperactivity ratings. Further, across both samples we evaluated the extent to which the ecological validity evidence for these mechanical measures of hyperactivity varies as a function of the task children are completing while their movement is assessed objectively (low vs. high cognitive demands). Across two independent samples comprising clinically-evaluated children with and without ADHD (Ns=88, 184; M (ages) =9.2, 10.4; 6%, 33% girls; 68%, 70% White Non-Hispanic), latent path models indicated that clinic-based actigraphy during visuospatial working memory testing (high cognitive demands) demonstrated significant associations with both parent- and teacher-rated hyperactivity that were indistinguishable (p>.05) from parent and teacher ratings's associations with each other in both sample 1 (r=.57) and sample 2 (r=.35; all p<.001). Actigraphy during baseline (low cognitive demand) conditions also uniquely predicted hyperactivity at home and school in both samples (all p<.001), albeit with a less consistent yet robust pattern relative to parent/teacher associations. In both samples, actigraphy showed strong test-retest reliability over 2-4 weeks across clinic-based tasks with high cognitive demands (r=.61-.93) and high concurrent validity across tasks with high vs. low cognitive demands (r=.35-.61; all p<.007). This pattern supports the ecological validity of clinic-based actigraphy during working memory testing, which predicts real-world behavior at home and school just as well as parent perceptions of hyperactivity at home predict teacher perceptions of hyperactivity at school (and vice versa). FAU - Kofler, Michael J AU - Kofler MJ AD - Florida State University, Department of Psychology. FAU - Soto, Elia F AU - Soto EF AD - Louisiana State University, Department of Psychology. FAU - Rapport, Mark D AU - Rapport MD AD - University of Central Florida, Department of Psychology. FAU - Whitehead, Samuel AU - Whitehead S AD - University of Central Florida, Department of Psychology. LA - eng GR - R01 MH115048/MH/NIMH NIH HHS/United States GR - R01 MH125893/MH/NIMH NIH HHS/United States GR - R61 MH127031/MH/NIMH NIH HHS/United States PT - Journal Article DEP - 20250531 PL - United States TA - J Psychopathol Behav Assess JT - Journal of psychopathology and behavioral assessment JID - 8608482 PMC - PMC12380012 MID - NIHMS2090164 OTO - NOTNLM OT - ADHD OT - actigraph OT - ecological validity OT - hyperactivity COIS- Conflict of Interest: The authors have no conflicts of interest to report. EDAT- 2025/08/29 08:48 MHDA- 2025/08/29 08:49 PMCR- 2025/08/27 CRDT- 2025/08/28 04:28 PHST- 2025/08/29 08:49 [medline] PHST- 2025/08/29 08:48 [pubmed] PHST- 2025/08/28 04:28 [entrez] PHST- 2025/08/27 00:00 [pmc-release] AID - 45 [pii] AID - 10.1007/s10862-025-10218-8 [doi] PST - ppublish SO - J Psychopathol Behav Assess. 2025 Jun;47(2):45. doi: 10.1007/s10862-025-10218-8. Epub 2025 May 31. PMID- 40869737 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250914 LR - 20250914 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 14 IP - 16 DP - 2025 Aug 21 TI - Updated Swiss Growth References 2025: No Height Differences, but BMI Variations Associated with Migration. LID - 10.3390/jcm14165912 [doi] LID - 5912 AB - Background/Objectives: The 2019 Swiss growth references for height, weight, and BMI were based on a large dataset from the German-speaking part of Switzerland (Cohort 2019). The current study aimed to ensure national representativeness by proportionate amounts of additional data from the French-speaking (Suisse Romande) and Italian-speaking (Ticino) regions to validate the 2019 growth curves and to update the national growth references. It also investigated the influence of parental migration background on child growth. Methods: Anthropometric data from 43,290 children and adolescents-including 11,816 new cases-were analyzed (Cohort 2019 + 2025). Percentile curves were modeled using the Generalized Additive Models for Location, Scale, and Shape (GAMLSS) framework. Results: The extended dataset largely confirms the 2019 growth references. Variations in height percentiles were small and clinically negligible. Clinically relevant differences in BMI percentiles were observed in girls, with the most pronounced deviations-up to 0.8 kg/m(2)-at the 97th percentile. Analyses by parental migration background revealed relevant differences in BMI. Conclusions: The extended Swiss Growth References (Cohort 2019 + 2025) are robust and provide valid reference data for all Swiss children and adolescents, offering contemporary tools for decision-making in clinical practice. To maintain their validity over time, targeted updates are required, with special attention to demographic changes resulting from migration. FAU - Eiholzer, Urs AU - Eiholzer U AUID- ORCID: 0000-0001-5044-0715 AD - Center for Paediatric Endocrinology Zurich (PEZZ), Moehrlistrasse 69, 8006 Zurich, Switzerland. FAU - Stephan, Anika AU - Stephan A AUID- ORCID: 0000-0003-0312-743X AD - Center for Paediatric Endocrinology Zurich (PEZZ), Moehrlistrasse 69, 8006 Zurich, Switzerland. FAU - Dubinski, Ilja AU - Dubinski I AUID- ORCID: 0000-0003-3670-2453 AD - Center for Paediatric Endocrinology Zurich (PEZZ), Moehrlistrasse 69, 8006 Zurich, Switzerland. FAU - Fritz, Christiane AU - Fritz C AD - Center for Paediatric Endocrinology Zurich (PEZZ), Moehrlistrasse 69, 8006 Zurich, Switzerland. FAU - Noordam, Cees AU - Noordam C AUID- ORCID: 0000-0001-9735-5921 AD - Center for Paediatric Endocrinology Zurich (PEZZ), Moehrlistrasse 69, 8006 Zurich, Switzerland. LA - eng PT - Journal Article DEP - 20250821 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC12387566 OTO - NOTNLM OT - body mass index OT - childhood obesity OT - growth curves OT - growth references OT - percentiles OT - public health COIS- The authors declare no conflicts of interest. EDAT- 2025/08/28 08:46 MHDA- 2025/08/28 08:47 PMCR- 2025/08/21 CRDT- 2025/08/28 01:13 PHST- 2025/07/18 00:00 [received] PHST- 2025/08/15 00:00 [revised] PHST- 2025/08/19 00:00 [accepted] PHST- 2025/08/28 08:47 [medline] PHST- 2025/08/28 08:46 [pubmed] PHST- 2025/08/28 01:13 [entrez] PHST- 2025/08/21 00:00 [pmc-release] AID - jcm14165912 [pii] AID - jcm-14-05912 [pii] AID - 10.3390/jcm14165912 [doi] PST - epublish SO - J Clin Med. 2025 Aug 21;14(16):5912. doi: 10.3390/jcm14165912. PMID- 40866068 OWN - NLM STAT- MEDLINE DCOM- 20250828 LR - 20250905 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 8 DP - 2025 Aug 27 TI - Screening hypertension using non-laboratory risk factors with machine learning: a retrospective cross-sectional study in Indonesia. PG - e092364 LID - 10.1136/bmjopen-2024-092364 [doi] LID - e092364 AB - OBJECTIVE: This study aimed to screen for hypertension in a vast Indonesian population using machine learning (ML) and 11 non-laboratory risk factors, validating the results through internal and external validations. SETTING AND PARTICIPANTS: From the initial 1 782 365 participants aged 15 and above registered at the Integrated Counseling Post primary care centres across Indonesia from 2014 to 2017, incomplete data and outliers were excluded, and 268 210 participants were included in our analysis. The dataset was split deterministically into a dataset for training using 10-fold internal cross-validation of 204 315 participants and another dataset for external validation of 63 895 participants. DESIGN: This retrospective cross-sectional study used three ML algorithms, that is, random forest, gradient boosting and extreme gradient boosting (XGBoost), and compared them against logistic regression as a benchmark to screen hypertension based on the WHO and International Society of Hypertension criteria. The importance of the risk factors was ranked. By partly using continuous versus categorical age, waist circumference (WC) and body mass index (BMI) risk factors, we evaluated the screening performance regarding sensitivity and area under the receiver operating characteristic curve (AUC). RESULTS: The external validations revealed that the XGBoost model performed the best in hypertension screening. The external validation, which partly uses continuous variables, provides 0.97 sensitivity and 0.75 AUC, indicating excellent screening capability. The importance rank of the risk factors was consecutively family history of hypertension (FH-HTN), age, WC, BMI, occupation, education, sex, smoking, low physical activity, lack of fruit or vegetable intake and alcohol consumption. CONCLUSIONS: By using 11 easy-to-collect non-laboratory risk factors, the ML model successfully screens for hypertension with better performance than the benchmark. Using the numerical variables of age, WC and BMI yields a better discrimination capability than the categorical variables. FH-HTN and age are the two top risk factors for the development of hypertension. This study is a useful academic exercise and shows ML's importance in handling large data sets. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Estiko, Reza Ishak AU - Estiko RI AUID- ORCID: 0000-0003-0241-2220 AD - Prof. Dr. Margono Soekarjo General Hospital, Purwokerto, Central Java, Indonesia. FAU - Widyantoro, Bambang AU - Widyantoro B AUID- ORCID: 0000-0001-5325-4125 AD - Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Special Capital Region of Jakarta, Indonesia. FAU - Juzar, Dafsah Arifa AU - Juzar DA AUID- ORCID: 0000-0001-8392-4759 AD - Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Special Capital Region of Jakarta, Indonesia. FAU - Yusup, Ramdhan Maulana AU - Yusup RM AUID- ORCID: 0009-0003-2590-7135 AD - Magister of Information Systems, Postgraduate Faculty, Universitas Komputer Indonesia, Bandung, West Java, Indonesia. FAU - Rakhmat, Iqbal Fauzi AU - Rakhmat IF AUID- ORCID: 0009-0006-4894-7676 AD - Magister of Information Systems, Postgraduate Faculty, Universitas Komputer Indonesia, Bandung, West Java, Indonesia. FAU - Rijanto, Estiko AU - Rijanto E AUID- ORCID: 0000-0003-0707-8209 AD - Magister of Information Systems, Postgraduate Faculty, Universitas Komputer Indonesia, Bandung, West Java, Indonesia estiko.rijanto@brin.go.id. AD - Research Center for Smart Mechatronics, National Research and Innovation Agency Republic of Indonesia, Bandung, West Java, Indonesia. LA - eng PT - Journal Article DEP - 20250827 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Indonesia/epidemiology MH - Cross-Sectional Studies MH - Retrospective Studies MH - Female MH - *Hypertension/diagnosis/epidemiology MH - *Machine Learning MH - Male MH - Risk Factors MH - Middle Aged MH - Adult MH - Body Mass Index MH - *Mass Screening/methods MH - ROC Curve MH - Waist Circumference MH - Aged MH - Young Adult MH - Adolescent PMC - PMC12406909 OTO - NOTNLM OT - Hypertension OT - Machine Learning OT - Mass Screening OT - Risk Factors COIS- Competing interests: None declared. EDAT- 2025/08/28 00:47 MHDA- 2025/08/28 19:08 PMCR- 2025/08/27 CRDT- 2025/08/27 21:03 PHST- 2025/08/28 19:08 [medline] PHST- 2025/08/28 00:47 [pubmed] PHST- 2025/08/27 21:03 [entrez] PHST- 2025/08/27 00:00 [pmc-release] AID - bmjopen-2024-092364 [pii] AID - 10.1136/bmjopen-2024-092364 [doi] PST - epublish SO - BMJ Open. 2025 Aug 27;15(8):e092364. doi: 10.1136/bmjopen-2024-092364. PMID- 40863715 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250914 LR - 20250914 IS - 2036-749X (Print) IS - 2036-7503 (Electronic) IS - 2036-749X (Linking) VI - 17 IP - 4 DP - 2025 Jul 28 TI - Validation of Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)-Related Pediatric Treatment Evaluation Checklist (PTEC). LID - 10.3390/pediatric17040081 [doi] LID - 81 AB - BACKGROUND/OBJECTIVES: The objective of this study was to validate a new parent-reported scale for tracking Pediatric Acute-onset Neuropsychiatric Syndrome (PANS). PANS is a condition characterized by a sudden and severe onset of neuropsychiatric symptoms. To meet diagnostic criteria, an individual must present with either obsessive-compulsive disorder (OCD) or severely restricted food intake, accompanied by at least two additional cognitive, behavioral, or emotional symptoms. These may include anxiety, emotional instability, depression, irritability, aggression, oppositional behaviors, developmental or behavioral regression, a decline in academic skills such as handwriting or math, sensory abnormalities, frequent urination, and enuresis. The onset of symptoms is usually triggered by an infection or an abnormal immune/inflammatory response. Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) is a subtype of PANS specifically linked to strep infections. METHODS: We developed a 101-item PANS/PANDAS and Related Inflammatory Brain Disorders Treatment Evaluation Checklist (PTEC) designed to assess changes to a patient's symptoms over time along 10 subscales: Behavior/Mood, OCD, Anxiety, Food intake, Tics, Cognitive/Developmental, Sensory, Other, Sleep, and Health. The psychometric quality of PTEC was tested with 225 participants. RESULTS: The internal reliability of the PTEC was excellent (Cronbach's alpha = 0.96). PTEC exhibited adequate test-retest reliability (r = 0.6) and excellent construct validity, supported by a strong correlation with the Health subscale of the Autism Treatment Evaluation Checklist (r = 0.8). CONCLUSIONS: We hope that PTEC will assist parents and clinicians in the monitoring and treatment of PANS. The PTEC questionnaire is freely available at neuroimmune.org/PTEC. FAU - Vyshedskiy, Andrey AU - Vyshedskiy A AUID- ORCID: 0000-0002-1610-8716 AD - Metropolitan College, Boston University, Boston, MA 02215, USA. FAU - Conkey, Anna AU - Conkey A AD - Neuroimmune Foundation, Saint Augustine, FL 32084, USA. FAU - DeWeese, Kelly AU - DeWeese K AD - Neuroimmune Foundation, Saint Augustine, FL 32084, USA. FAU - Junghanns, Frank Benno AU - Junghanns FB AD - Neuroimmune Foundation, Saint Augustine, FL 32084, USA. FAU - Adams, James B AU - Adams JB AUID- ORCID: 0000-0001-8683-4062 AD - School for Engineering of Matter, Transport and Energy, Arizona State University, Tempe, AZ 85281, USA. FAU - Frye, Richard E AU - Frye RE AUID- ORCID: 0000-0003-4442-2937 AD - Autism Discovery and Treatment Foundation, Phoenix, AZ 85050, USA. LA - eng GR - N/A/This research was supported by funding from the Neuroimmune Foundation and Neuroimmune North Carolina./ PT - Journal Article DEP - 20250728 PL - Switzerland TA - Pediatr Rep JT - Pediatric reports JID - 101551542 PMC - PMC12389426 OTO - NOTNLM OT - PANDAS OT - PANS OT - neuropsychiatric syndrome OT - psychological evaluations OT - streptococcal infections COIS- The authors declare no conflicts of interest. EDAT- 2025/08/28 20:51 MHDA- 2025/08/28 20:52 PMCR- 2025/07/28 CRDT- 2025/08/27 10:23 PHST- 2025/06/09 00:00 [received] PHST- 2025/07/18 00:00 [revised] PHST- 2025/07/23 00:00 [accepted] PHST- 2025/08/28 20:52 [medline] PHST- 2025/08/28 20:51 [pubmed] PHST- 2025/08/27 10:23 [entrez] PHST- 2025/07/28 00:00 [pmc-release] AID - pediatric17040081 [pii] AID - pediatrrep-17-00081 [pii] AID - 10.3390/pediatric17040081 [doi] PST - epublish SO - Pediatr Rep. 2025 Jul 28;17(4):81. doi: 10.3390/pediatric17040081. PMID- 40859543 OWN - NLM STAT- MEDLINE DCOM- 20250827 LR - 20250903 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 104 IP - 34 DP - 2025 Aug 22 TI - Insights on eating behaviors among adult females in Jordan: A national survey study. PG - e44073 LID - 10.1097/MD.0000000000044073 [doi] LID - e44073 AB - Culture plays an important role in determining the type of food in societies. Most people suffer from challenges related to eating habits as many young women have a lack of acceptance of their body shape. Between April 20, 2025 and May 31, 2025, a cross-sectional study was conducted utilizing an online survey tool in Jordan to examine female adults eating behavior. This study used the Arabic version of a previously validated questionnaire named Adult Eating Behavior Questionnaire. Logistic regression analysis was conducted to predict significant factors influencing the food behaviors. A total of 702 females were involved in this study. The mean food approach subscale score was 44.8 +/- 10.3, demonstrating more positive attitude towards approaching foods. Among the food approach subscales, "Enjoyment of Food" showed the highest mean score (21.23 +/- 4.12), corresponding to 70.7% of the maximum possible score, while "Emotional Over-Eating" had the lowest mean score at 12.64 +/- 5.6 (50.5%). The mean food avoidance subscale score was 38.1 +/- 6.2, demonstrating more positive attitude towards foods avoidance. In the food avoidance subscales, "Food Fussiness" recorded the highest mean score (14.34 +/- 2.36; 71.7%), while "slowness in Eating" had the lowest mean score at 11.55 +/- 3.87 (57.7%). Overweight and obese individuals had higher odds of food approach behaviors compared to underweight individuals (OR = 1.77, 95% CI: 1.09-2.88, P = .02, OR = 3.40, 95% CI: 1.41-8.19, P = .006), respectively. Conversely, overweight and obese participants had significantly lower odds of food avoidance behaviors (OR = 0.38, 95% CI: 0.23-0.62, P < .001, OR = 0.27, 95% CI: 0.11-0.67, P = .00), respectively. Additionally, participants working in nonmedical fields had lower odds of food avoidance behaviors compared to those not working (OR = 0.36, 95% CI: 0.16-0.78, P = .01). Both food approach and avoidance behaviors were positively viewed by females in Jordan, with "Food Fussiness" and "Enjoyment of Food" being the most prominent features. Overweight and obese females had higher food approach and lower food avoidance behaviors, suggesting a behavioral pattern that may contribute to excess weight. These findings highlight the complex link between sociodemographic parameters including body weight and diet. CI - Copyright (c) 2025 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Sweiss, Kanar AU - Sweiss K AD - Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Middle East University (MEU), Amman, Jordan. FAU - Naser, Abdallah Y AU - Naser AY AUID- ORCID: 0000-0001-8440-7446 AD - Department of Applied Pharmaceutical Sciences and Clinical Pharmacy, Faculty of Pharmacy, Isra University, Amman, Jordan. FAU - Alsharif, Alaa A AU - Alsharif AA AD - Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. LA - eng GR - PNURSP2025R483/This research was supported by Princess Nourah bint Abdulrahman University Researchers Supporting/ PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Female MH - Jordan/epidemiology MH - *Feeding Behavior/psychology MH - Adult MH - Cross-Sectional Studies MH - Young Adult MH - Middle Aged MH - Surveys and Questionnaires MH - Adolescent PMC - PMC12384799 OTO - NOTNLM OT - approach OT - avoidance OT - behavior OT - eating OT - females OT - food COIS- The authors have no conflicts of interest to disclose. EDAT- 2025/08/28 20:50 MHDA- 2025/08/28 20:51 PMCR- 2025/08/22 CRDT- 2025/08/27 01:02 PHST- 2025/06/08 00:00 [received] PHST- 2025/08/01 00:00 [accepted] PHST- 2025/08/28 20:51 [medline] PHST- 2025/08/28 20:50 [pubmed] PHST- 2025/08/27 01:02 [entrez] PHST- 2025/08/22 00:00 [pmc-release] AID - 00005792-202508220-00072 [pii] AID - MD-D-25-06982 [pii] AID - 10.1097/MD.0000000000044073 [doi] PST - ppublish SO - Medicine (Baltimore). 2025 Aug 22;104(34):e44073. doi: 10.1097/MD.0000000000044073. PMID- 40855417 OWN - NLM STAT- MEDLINE DCOM- 20250826 LR - 20260617 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 25 IP - 1 DP - 2025 Aug 25 TI - "Active behaviour of parents is more associated with out-of-school physical activity in their children". PG - 650 LID - 10.1186/s12887-025-06014-8 [doi] LID - 650 AB - BACKGROUND: Active parents may have more active children, as parents act as role models for their children's physical activity (PA). Parents can facilitate access to PA, provide information, validate physical-sport behaviours, and offer emotional support. Also, the influence of parents' PA on children's PA in and out of the school context has not been well-established. OBJECTIVE: This study aimed to examine the associations between parental PA and the PA levels of their children in both school and out-of-school settings, considering parental sex. METHODS: A cross-sectional study was conducted in 2021 involving 1,030 parent-child dyads. Sociodemographic data and self-reported active behaviour measures were administered to both groups simultaneously. Multiple logistic regressions were performed to determine the associations. RESULTS: A positive trend between parental and children's PA was observed only out of school (Trend OR = 1.55, 95% CI = 1.25-1.95; p < 0.001). Maternal moderate-to-vigorous physical activity (MVPA) of 151-300 min per week was associated with MVPA in children on school days with physical education classes (OR = 3.48; 95% CI, 1.04-12.1). A trend was found in the maternal group for MVPA in children out of school (Trend OR = 1.57 [95% CI = 1.24; 2.01]). CONCLUSION: Positive associations between MVPA in children and more than 150 min of MVPA per week from parents were found. Also, a trend between maternal PA and their children's out-of-school MVPA was identified, supporting future initiatives focused on family-based PA interventions. CI - (c) 2025. The Author(s). FAU - Rodriguez-Rodriguez, Fernando AU - Rodriguez-Rodriguez F AD - IRyS Group, School of Physical Education, Pontificia Universidad Catolica de Valparaiso, Valparaiso, Chile. fernando.rodriguez@pucv.cl. FAU - Hernandez-Jana, Sam AU - Hernandez-Jana S AD - IRyS Group, School of Physical Education, Pontificia Universidad Catolica de Valparaiso, Valparaiso, Chile. FAU - Castro-Pinero, Jose AU - Castro-Pinero J AD - GALENO Research Group, Department of Physical Education, Faculty of Education Sciences, School of Education, University of Cadiz, Puerto Real, Cadiz, Spain. AD - Instituto de Investigacion e Innovacion Biomedica de Cadiz (INiBICA), University of Cadiz, Cadiz, 11009, Spain. FAU - Brazo-Sayavera, Javier AU - Brazo-Sayavera J AD - Department of Sports and Computer Science, Universidad Pablo de Olavide (UPO), Seville, 41013, Spain. FAU - Carcamo-Oyarzun, Jaime AU - Carcamo-Oyarzun J AD - CIAM Physical Literacy Research Centre, Faculty of Education, Social Science & amp; Humanities, Universidad de La Frontera, Temuco, Chile. FAU - Rhodes, Ryan E AU - Rhodes RE AD - School of Exercise Science, Physical and Health Education, University of Victoria, Victoria, BC, V8P 5C2, Canada. LA - eng GR - 1230801/FONDECYT of the Agencia Nacional de Investigacion y Desarrollo (ANID) of Chilean Government. FONDECYT Regular project 2023/ PT - Journal Article DEP - 20250825 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Male MH - Child MH - *Exercise MH - *Parent-Child Relations MH - Adult MH - *Parents/psychology MH - Schools MH - Logistic Models PMC - PMC12376377 OTO - NOTNLM OT - Exercise OT - Family OT - Father OT - Mother OT - Physical education COIS- Declarations. Ethics approval and consent to participate: The project adheres to the principles outlined in the Declaration of Helsinki (World Medical Association, 2013), with approval obtained from the Bioethics Committee of the Pontificia Universidad Catolica de Valparaiso, Chile (Code: BIOEPUCV-H 638-2023). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/08/28 04:51 MHDA- 2025/08/28 04:52 PMCR- 2025/08/25 CRDT- 2025/08/26 00:11 PHST- 2025/05/22 00:00 [received] PHST- 2025/07/30 00:00 [accepted] PHST- 2025/08/28 04:52 [medline] PHST- 2025/08/28 04:51 [pubmed] PHST- 2025/08/26 00:11 [entrez] PHST- 2025/08/25 00:00 [pmc-release] AID - 10.1186/s12887-025-06014-8 [pii] AID - 6014 [pii] AID - 10.1186/s12887-025-06014-8 [doi] PST - epublish SO - BMC Pediatr. 2025 Aug 25;25(1):650. doi: 10.1186/s12887-025-06014-8. PMID- 40855297 OWN - NLM STAT- MEDLINE DCOM- 20250826 LR - 20260617 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 25 IP - 1 DP - 2025 Aug 25 TI - Neck-to-height ratio in screening for abdominal obesity among children and adolescents: a cross-sectional study. PG - 651 LID - 10.1186/s12887-025-05955-4 [doi] LID - 651 AB - BACKGROUND: With the increasing prevalence of abdominal obesity among children and adolescents, identifying easily measurable, safe, efficient, low-cost, and highly effective indicators is crucial in public health management. While neck-to-height ratio (NHtR) is a better indicator of upper body fat than neck circumference (NC), current research on this indicator mainly assesses its role in obesity and related metabolic diseases among adults. Therefore, this study aimed to investigate the clinical significance of the (NHtR) in screening for abdominal obesity among children and adolescents. METHODS: The cross-sectional study enrolled 3,728 children and adolescents aged 7-17 years. Participants were categorized into three groups: abdominal obesity, pre-abdominal obesity, and normal. Continuous variables (NC, NHtR, WC, WHtR) were compared using analysis of variance or the Kruskal-Wallis H test. Partial correlation analysis was conducted between NHtR and WC/WHtR.ROC curve analysis assessed NHtR's accuracy in screening abdominal obesity. A subset of 970 participants underwent model validation using both internal (7:3 split) and external datasets, evaluated by receiver operating characteristic (ROC), area under the curve (AUC), and calibration curves. RESULTS: The prevalence of abdominal obesity was 22.91% among participants. Significant statistical differences were observed in NC and NHtR among the three groups. After controlling for age, partial correlation analysis revealed positive correlations between NHtR and both WC and WHtR in boys and girls. Receiver operating characteristic curve analysis revealed that the area under the curve for NHtR, in assisting with the screening of abdominal obesity, was 0.810. The optimal cutoff values of NHtR were 0.21 and 0.20 for boys and girls, respectively, with age-specific values ranging from 0.20 to 0.22. Furthermore, the NHtR model demonstrated strong predictive ability for abdominal obesity, with excellent goodness of fit. CONCLUSIONS: This study highlights NHtR as an effective indicator for screening abdominal obesity in children and adolescents, supporting early detection and intervention strategies to improve public health outcomes related to abdominal obesity. CI - (c) 2025. The Author(s). FAU - Liu, Fang AU - Liu F AD - Department of Endocrinology and Inherited Metabolic, Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, 33 Longhu Outer Ring East Road, Zhengdong New District, Zhengzhou, Henan, 450018, China. FAU - Yuan, Shuxian AU - Yuan S AD - Department of Endocrinology and Inherited Metabolic, Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, 33 Longhu Outer Ring East Road, Zhengdong New District, Zhengzhou, Henan, 450018, China. FAU - Ma, Xiaocui AU - Ma X AD - Children's Research Institute, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, 450018, Henan, China. FAU - Li, Yangshiyu AU - Li Y AD - Department of Endocrinology and Inherited Metabolic, Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, 33 Longhu Outer Ring East Road, Zhengdong New District, Zhengzhou, Henan, 450018, China. FAU - Wang, Shiqi AU - Wang S AD - Department of Endocrinology and Inherited Metabolic, Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, 33 Longhu Outer Ring East Road, Zhengdong New District, Zhengzhou, Henan, 450018, China. FAU - Lin, Yifan AU - Lin Y AD - Department of Endocrinology and Inherited Metabolic, Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, 33 Longhu Outer Ring East Road, Zhengdong New District, Zhengzhou, Henan, 450018, China. FAU - Chen, Yongxing AU - Chen Y AD - Department of Endocrinology and Inherited Metabolic, Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, 33 Longhu Outer Ring East Road, Zhengdong New District, Zhengzhou, Henan, 450018, China. FAU - Wei, Haiyan AU - Wei H AUID- ORCID: 0000-0001-6240-114X AD - Department of Endocrinology and Inherited Metabolic, Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, 33 Longhu Outer Ring East Road, Zhengdong New District, Zhengzhou, Henan, 450018, China. haiyanwei2009@163.com. AD - Children's Research Institute, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, 450018, Henan, China. haiyanwei2009@163.com. AD - Tianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Sciences, Zhengzhou University, 40 University North Road, Erqi District, Zhengzhou, Henan, 450018, China. haiyanwei2009@163.com. LA - eng GR - 2021YFC2701900/National Key Research and Development Program of China/ PT - Journal Article DEP - 20250825 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Child MH - Cross-Sectional Studies MH - Adolescent MH - *Obesity, Abdominal/diagnosis/epidemiology MH - Female MH - Male MH - *Neck/anatomy & histology MH - *Body Height MH - Prevalence MH - *Mass Screening/methods MH - ROC Curve MH - *Pediatric Obesity/diagnosis/epidemiology PMC - PMC12376330 OTO - NOTNLM OT - Abdominal obesity OT - Adolescents OT - Children OT - Neck-to-height ratio OT - Screening COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Medical Ethics Committee of Zhengzhou University Children's Hospital (Ethics No.: 2021-H-K31). The study was performed in accordance with the ethical standards outlined in the 1964 Declaration of Helsinki and its later amendments or other comparable ethical standards. This study was conducted after informed consent to participate was obtained from the research participants and their parents, who signed the consent forms. Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests. Clinical trial number: Not applicable EDAT- 2025/08/28 04:46 MHDA- 2025/08/28 04:47 PMCR- 2025/08/25 CRDT- 2025/08/25 23:57 PHST- 2025/02/26 00:00 [received] PHST- 2025/07/11 00:00 [accepted] PHST- 2025/08/28 04:47 [medline] PHST- 2025/08/28 04:46 [pubmed] PHST- 2025/08/25 23:57 [entrez] PHST- 2025/08/25 00:00 [pmc-release] AID - 10.1186/s12887-025-05955-4 [pii] AID - 5955 [pii] AID - 10.1186/s12887-025-05955-4 [doi] PST - epublish SO - BMC Pediatr. 2025 Aug 25;25(1):651. doi: 10.1186/s12887-025-05955-4. PMID- 40865036 OWN - NLM STAT- MEDLINE DCOM- 20251020 LR - 20251205 IS - 1939-327X (Electronic) IS - 0012-1797 (Linking) VI - 74 IP - 11 DP - 2025 Nov 1 TI - Metabolome-Wide Mendelian Randomization and Observational Study Reveal Causal Links Between Circulating Metabolites and Youth-Onset Type 2 Diabetes. PG - 2140-2151 LID - 10.2337/db25-0093 [doi] AB - Despite the increasing prevalence of type 2 diabetes in youth, its causal associations with circulating biomarkers remain elusive. We first aimed to identify circulating metabolites causally linked to youth-onset type 2 diabetes using Mendelian randomization (MR). By analyzing 675 metabolites from large metabolomic European genome-wide association studies (GWAS) and data on youth type 2 diabetes from the multiancestry Progress in Diabetes Genetics in Youth (ProDiGY) consortium, we identified 34 candidate metabolites. Among these, phosphatidylcholine (pc) ae C42:3 and propionylcarnitine provided the strongest evidence of association with youth-onset type 2 diabetes, based also on positive genetic colocalization and sensitivity analyses accounting for adiposity. Among the 34 candidate metabolites, 23 were retained following colocalization and a replication MR using independent metabolomic GWAS and testing effects on adult type 2 diabetes. Furthermore, we validated associations of six of these metabolites with glucose metabolism-related traits in an observational study in the Avon Longitudinal Study of Parents and Children (ALSPAC). Notably, pc ae C42:3 levels at age 7 years were linked to dysglycemia and insulin resistance in adolescence. These findings underscore the dynamic role of metabolites in glucose metabolism in childhood, offering insights for future screening and treatment strategies. ARTICLE HIGHLIGHTS: Metabolism is key in the pathogenesis of type 2 diabetes in both children and adults, and large-scale metabolomic studies offer a unique source for discovery of biomarkers for these conditions. Leveraging human genetics, we explored whether altered levels of circulating metabolites in the blood are causally linked to type 2 diabetes in youth across different ancestries. Our Mendelian randomization analysis identified causal associations for 34 metabolites, and, among these, Mendelian randomization replication and colocalization prioritized 23 metabolites. Observational evidence from the Avon Longitudinal Study of Parents and Children (ALSPAC) study validated effects on glucose homeostasis for six of these metabolites, among which phosphatidylcholine ae C42:3 emerged as the most promising biomarker. These findings highlight the role of metabolism in glucose homeostasis pathophysiology in youth. CI - (c) 2025 by the American Diabetes Association. FAU - Fagbemi, Kaossarath AU - Fagbemi K AD - Research Center of the CHU Sainte-Justine University Hospital, Universite de Montreal, Montreal, Quebec, Canada. FAU - Avocegamou, Raphael AU - Avocegamou R AD - Research Center of the CHU Sainte-Justine University Hospital, Universite de Montreal, Montreal, Quebec, Canada. FAU - Yazdanpanah, Nahid AU - Yazdanpanah N AD - Research Center of the CHU Sainte-Justine University Hospital, Universite de Montreal, Montreal, Quebec, Canada. FAU - Yazdanpanah, Mojgan AU - Yazdanpanah M AD - Research Center of the CHU Sainte-Justine University Hospital, Universite de Montreal, Montreal, Quebec, Canada. FAU - Jumentier, Basile AU - Jumentier B AD - Research Center of the CHU Sainte-Justine University Hospital, Universite de Montreal, Montreal, Quebec, Canada. FAU - Gamache, Isabel AU - Gamache I AD - Research Center of the CHU Sainte-Justine University Hospital, Universite de Montreal, Montreal, Quebec, Canada. FAU - Manousaki, Despoina AU - Manousaki D AUID- ORCID: 0000-0002-4133-0618 AD - Research Center of the CHU Sainte-Justine University Hospital, Universite de Montreal, Montreal, Quebec, Canada. AD - Departments of Pediatrics and Biochemistry and Molecular Medicine, Universite de Montreal, Montreal, Quebec, Canada. LA - eng GR - 217065/Z/19/Z/The UK Medical Research Council/ GR - Career Development Award/ENRICH/ GR - Junior 1 scholar/Fonds de Recherche du Quebec - Sante/ GR - University of Bristol/ PT - Journal Article PT - Observational Study PL - United States TA - Diabetes JT - Diabetes JID - 0372763 RN - 0 (Biomarkers) RN - 0 (Phosphatidylcholines) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/genetics/metabolism/blood MH - Mendelian Randomization Analysis MH - Genome-Wide Association Study MH - Adolescent MH - Child MH - *Metabolome/genetics MH - Male MH - Female MH - Insulin Resistance/genetics MH - Biomarkers/blood MH - Metabolomics MH - Adult MH - Phosphatidylcholines/blood EDAT- 2025/08/27 20:45 MHDA- 2025/10/21 00:28 CRDT- 2025/08/27 16:03 PHST- 2025/01/28 00:00 [received] PHST- 2025/08/06 00:00 [accepted] PHST- 2025/10/21 00:28 [medline] PHST- 2025/08/27 20:45 [pubmed] PHST- 2025/08/27 16:03 [entrez] AID - 163312 [pii] AID - 10.2337/db25-0093 [doi] PST - ppublish SO - Diabetes. 2025 Nov 1;74(11):2140-2151. doi: 10.2337/db25-0093. PMID- 40864566 OWN - NLM STAT- MEDLINE DCOM- 20250828 LR - 20251016 IS - 1930-8264 (Electronic) IS - 1930-8264 (Linking) VI - 115 IP - 4 DP - 2025 Jul-Aug TI - Toe Walking Tool. LID - 24-068 [pii] LID - 10.7547/24-068 [doi] AB - BACKGROUND: The Toe Walking Tool is used to highlight the need for further investigation of toe-walking children by a more qualified expert. Such a tool is not yet available within Greek clinical settings. Therefore, the aim of this study was to translate and cross-culturally adapt into Greek the Toe Walking Tool. METHODS: The Toe Walking Tool was translated into Greek according to international guidelines by five pediatric physiotherapists, all fluent in the English language. Fifteen children with toe-walking due to pathologic reasons or idiopathic toe-walking were video-recorded performing the tasks and tests of the tool. Parents answered the questions regarding the children's medical history. Seven pediatric physiotherapists evaluated the 15 children using the video recordings and the parents' answers to complete the tool. Data were analyzed with Fleiss kappa, percentage agreement, and chi2 tests. Face and content validity was determined by a group of experts. RESULTS: The Greek version of the Toe Walking Tool proved to be clinically applicable and user-friendly. The tool was also found to have substantial intrarater reliability, with a Fleiss kappa index of 0.73. The percentage agreement between the seven raters was high to very high, ranging from 86% to 100%, and no statistical differences were found between the raters (P < .1). CONCLUSIONS: The Greek version of the Toe Walking Tool demonstrated adequate evidence of interrater reliability and can be used to refer, if required, toe-walking children for further investigation. FAU - Skarmoutsou, Eleni AU - Skarmoutsou E AD - *First EPAL of Peristeri, Athens, Greece. FAU - Bania, Theofani AU - Bania T AD - daggerDepartment of Physiotherapy, University of Patras, Rio, Greece. FAU - Potamiti, Eleni AU - Potamiti E AD - double daggerEarly Intervention and Rehabilitation Center of the Panagiotis and Aglaia's Kuriakou Children's Hospital, Kallithea, Greece. FAU - Tsouni, Dimitra AU - Tsouni D AD - section signELEPAP Department of Agrinio, Agrinio, Greece. FAU - Panagaki, Panagiota AU - Panagaki P AD - ||First Special Primary School of Patras, Patras, Greece. FAU - Koulosousa, Athina AU - Koulosousa A AD - paragraph signOnasseio Heart Surgery Center, Kallithea, Greece. FAU - Kalamvoki, Efstratia AU - Kalamvoki E AD - #Paidokinisis Child Physiotherapy Center, Argyroupoli, Greece. FAU - Billis, Evdokia AU - Billis E AD - daggerDepartment of Physiotherapy, University of Patras, Rio, Greece. LA - eng PT - Journal Article PL - Switzerland TA - J Am Podiatr Med Assoc JT - Journal of the American Podiatric Medical Association JID - 8501423 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - *Toes/physiology MH - Reproducibility of Results MH - *Walking/physiology MH - Greece MH - Child, Preschool MH - Video Recording EDAT- 2025/08/27 20:45 MHDA- 2025/08/28 07:09 CRDT- 2025/08/27 13:03 PHST- 2025/08/28 07:09 [medline] PHST- 2025/08/27 20:45 [pubmed] PHST- 2025/08/27 13:03 [entrez] AID - 24-068 [pii] AID - 10.7547/24-068 [doi] PST - ppublish SO - J Am Podiatr Med Assoc. 2025 Jul-Aug;115(4):24-068. doi: 10.7547/24-068. PMID- 40864382 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20261010 IS - 1559-0100 (Electronic) IS - 1355-008X (Linking) VI - 90 IP - 2 DP - 2025 Nov TI - A knee bone age-based predictive nomogram for the poor response to growth hormone therapy in children with idiopathic short stature during mid-to-late puberty. PG - 852-862 LID - 10.1007/s12020-025-04398-2 [doi] AB - PURPOSE: To determine whether MRI-based knee bone age (KBA) could be a predictor for growth hormone therapy (GHT) response in idiopathic short stature (ISS) children during mid-to-late puberty, and to develop a KBA-based model for predicting the risk of poor GHT response (pGHR). METHODS: 80 adolescents aged over 10 years, at Tanner stage 3 or above, with height below - 2 SDS and a GH peak >/= 7 ng/dL were included in the study, dividing into pGHR (∆HTSDS<0.5SDS) and good GHT response (gGHR, ∆HTSDS>/=0.5SDS) groups. Univariable logistic regressions investigated associations between KBA, clinical features and pGHR risk. Multivariable logistic regression was established for nomogram development. Internal validation was performed using 1000-time self-bootstrapping. Nomogram performance was evaluated through discrimination, calibration, and clinical utility. RESULTS: KBA, chronological age, and Tanner stage were positively associated with the risk of pGHR, while the distance between predicted adult height and pretreatment height in SDS (PAHSDS-HTSDS) was negatively associated. Male with KBA > 14.5 years and female with KBA > 12.5 years had higher risk of pGHR. Multivariable logistic regression identified KBA, sex, and PAHSDS-HTSDS as independent predictors. A nomogram developed by these predictors showed good calibration and discrimination (AUC = 0.953). The score of internal validation also revealed good discrimination (AUCmean=0.960). CONCLUSIONS: KBA is a reliable predictor for GHT response in ISS children during mid-to-late puberty. A simple and predictive nomogram including KBA, sex and PAHSDS-HTSDS was developed to predict the pGHR risk, exhibiting good discriminative ability and clinical utility, which may assist clinicians make clinical decisions and minimize unnecessary interventions. FAU - Sun, Yuxin AU - Sun Y AD - Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China. AD - Eight-Year Program of Clinical Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China. FAU - Zhou, Zhibo AU - Zhou Z AD - Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China. FAU - Qiang, Jiaqi AU - Qiang J AD - Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China. FAU - Wang, Fengdan AU - Wang F AUID- ORCID: 0000-0003-2413-0646 AD - Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China. FAU - Chen, Shi AU - Chen S AUID- ORCID: 0000-0003-2205-5371 AD - Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China. cs0083@126.com. FAU - Pan, Hui AU - Pan H AD - Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China. panhui20111111@163.com. LA - eng GR - 2022YFC3600202/National Key Research and Development Program/ PT - Journal Article DEP - 20250827 PL - United States TA - Endocrine JT - Endocrine JID - 9434444 RN - 12629-01-5 (Human Growth Hormone) SB - IM MH - Humans MH - *Nomograms MH - Female MH - Male MH - Adolescent MH - Child MH - *Human Growth Hormone/therapeutic use MH - *Age Determination by Skeleton/methods MH - *Puberty MH - Body Height/drug effects MH - *Growth Disorders/drug therapy/diagnostic imaging MH - Magnetic Resonance Imaging MH - *Knee/diagnostic imaging MH - *Dwarfism/drug therapy MH - Treatment Outcome OTO - NOTNLM OT - Bone age OT - Growth hormone therapy OT - Idiopathic short stature OT - Magnetic resonance imaging OT - Puberty COIS- Declarations. Conflict of interest: The authors declare no competing interests. Statements and Declarations: This study was funded by the National Key Research and Development Program, with data available upon reasonable request, approved by the Ethics Committee of Peking Union Medical College Hospital, and the authors declare no conflicts of interest, confirming the work is original and has not been submitted or published elsewhere. EDAT- 2025/08/27 12:46 MHDA- 2026/06/27 06:45 CRDT- 2025/08/27 11:17 PHST- 2025/05/19 00:00 [received] PHST- 2025/08/11 00:00 [accepted] PHST- 2026/06/27 06:45 [medline] PHST- 2025/08/27 12:46 [pubmed] PHST- 2025/08/27 11:17 [entrez] AID - 10.1007/s12020-025-04398-2 [pii] AID - 10.1007/s12020-025-04398-2 [doi] PST - ppublish SO - Endocrine. 2025 Nov;90(2):852-862. doi: 10.1007/s12020-025-04398-2. Epub 2025 Aug 27. PMID- 40862130 OWN - NLM STAT- MEDLINE DCOM- 20250827 LR - 20250829 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 16 DP - 2025 TI - Development and internal validation of a machine learning algorithm for the risk of type 2 diabetes mellitus in children with obesity. PG - 1649988 LID - 10.3389/fendo.2025.1649988 [doi] LID - 1649988 AB - AIM: We aimed to develop and internally validate a machine learning (ML)-based model for the prediction of the risk of type 2 diabetes mellitus (T2DM) in children with obesity. METHODS: In total, 292 children with obesity and T2DM were enrolled between July 2023 and February 2024 and followed for at least 1 year. Eight ML algorithms (Decision Tree, Logistic Regression, Support Vector Machine (SVM), Multilayer Perceptron, Adaptive Boosting, Random Forest, Gradient Boosting Decision Tree, and Extreme Gradient Boosting) were compared for their capacity to identify key clinical and laboratory characteristics of T2DM in children and to create a risk prediction model. RESULTS: Forty-nine children were diagnosed with T2DM during the follow-up period. The SVM algorithm was the best predictor of T2DM, with the largest area under the receiver operating characteristic curve (0.98) and accuracy (93.2%). The SVM algorithm identified eight predictors: BMI, creatinine, prealbumin, glucose (180 min), glycosylated hemoglobin A1c, thyrotropin, total thyroxine (T4), and free T4 concentrations. Thus, an ML-based prediction model accurately identifies children with obesity at high risk of T2DM. If externally validated, this tool could facilitate early, personalized interventions aimed at preventing T2DM. DISCUSSION: The rising prevalence of obesity in childhood is associated with an increase in the risk of early-onset T2DM. Therefore, the early identification of individuals at high risk is crucial to prevent the development of this disease. In a comparative analysis of the performance of multiple ML algorithms, we found that the SVM algorithm was the best predictor of the development of T2DM. CI - Copyright (c) 2025 Yang, Liu, Huang, Wu, Wang, Cao, Wang, Zhang, Ai and Zhou. FAU - Yang, Jin-Xia AU - Yang JX AD - School of Medicine, Tongji University, Basic Medical Science, Shanghai, China. AD - Children's Hospital of Soochow University, Endocrine Genetic Metabolism, Suzhou, China. FAU - Liu, Yue AU - Liu Y AD - School of Medicine, Tongji University, Basic Medical Science, Shanghai, China. AD - Gongli Hospital, Pudong New District, Department of Orthopedic Surgery, Shanghai, China. FAU - Huang, Rong AU - Huang R AD - Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China. FAU - Wu, Hai-Ying AU - Wu HY AD - Children's Hospital of Soochow University, Endocrine Genetic Metabolism, Suzhou, China. FAU - Wang, Ya-Yun AU - Wang YY AD - Children's Hospital of Soochow University, Endocrine Genetic Metabolism, Suzhou, China. FAU - Cao, Su-Ying AU - Cao SY AD - Children's Hospital of Soochow University, Endocrine Genetic Metabolism, Suzhou, China. FAU - Wang, Guo-Ying AU - Wang GY AD - Children's Hospital of Soochow University, Endocrine Genetic Metabolism, Suzhou, China. FAU - Zhang, Jian-Min AU - Zhang JM AD - Children's Hospital of Soochow University, Department of Traditional Chinese Medical, Suzhou, China. FAU - Ai, Zi-Sheng AU - Ai ZS AD - School of Medicine, Tongji University, Basic Medical Science, Shanghai, China. FAU - Zhou, Hui-Min AU - Zhou HM AD - Children's Hospital of Soochow University, Endocrine Genetic Metabolism, Suzhou, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20250808 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/etiology/diagnosis/epidemiology MH - Female MH - Male MH - Child MH - *Machine Learning MH - *Pediatric Obesity/complications/epidemiology MH - *Algorithms MH - Risk Factors MH - Adolescent MH - Follow-Up Studies MH - Support Vector Machine MH - Risk Assessment PMC - PMC12370479 OTO - NOTNLM OT - children OT - machine learning OT - obesity OT - risk prediction model OT - type 2 diabetes mellitus COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/08/27 20:46 MHDA- 2025/08/27 20:47 PMCR- 2025/08/08 CRDT- 2025/08/27 06:48 PHST- 2025/06/24 00:00 [received] PHST- 2025/07/22 00:00 [accepted] PHST- 2025/08/27 20:47 [medline] PHST- 2025/08/27 20:46 [pubmed] PHST- 2025/08/27 06:48 [entrez] PHST- 2025/08/08 00:00 [pmc-release] AID - 10.3389/fendo.2025.1649988 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2025 Aug 8;16:1649988. doi: 10.3389/fendo.2025.1649988. eCollection 2025. PMID- 40861373 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250914 LR - 20250914 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 16 DP - 2025 TI - How physical activity enhances academic engagement in middle school: a serial mediation model of interpersonal relationships and academic support. PG - 1632130 LID - 10.3389/fpsyg.2025.1632130 [doi] LID - 1632130 AB - INTRODUCTION: Academic engagement is a critical aspect of adolescent development. Understanding the mechanism of academic engagement will help to take effective measures to improve the academic engagement of middle school students. This study used a serial mediation model to delve into the complex association among physical activity, interpersonal relationships, academic support, and academic engagement in middle school students. METHODS: A sample of 746 participants in middle school (51.1% female) completed validated measurement tools for each variable. RESULTS: Results showed that grade was negatively correlated with physical activity and academic engagement, yet positively associated with interpersonal relationships, and significant positive correlations among the four variables. In contrast, gender and only-child status had weak correlations with other measured variables. Findings from regression analyses further underscored that physical activity positively directly predicted academic engagement. Notably, mediation analyses showed that both interpersonal relationships and academic support mediated the separate relationship between physical activity and academic engagement, and they also supported the hypothesized serial mediation effect. The final serial mediation model effectively explained a substantial 31.8% portion of the variance in academic engagement. DISCUSSION: These findings comprehensively illustrate the complex interactions between physical activity and academic engagement, deepening our understanding of the determinants of the relationship between the two variables among middle school students. The study provides valuable empirical evidence for designing targeted interventions aimed at enhancing adolescents' academic engagement through improved physical activity, interpersonal relationships, and academic support. CI - Copyright (c) 2025 Zhang, Liu, Zhang and Hu. FAU - Zhang, Junmin AU - Zhang J AD - School of Sports Training, Chengdu Sport University, Chengdu, China. FAU - Liu, Yongfeng AU - Liu Y AD - School of Sports Training, Chengdu Sport University, Chengdu, China. FAU - Zhang, Xiaogang AU - Zhang X AD - School of Football Sports, Chengdu Sport University, Chengdu, China. FAU - Hu, Shuiyou AU - Hu S AD - School of Physical Education, Chengdu Sport University, Chengdu, China. LA - eng PT - Journal Article DEP - 20250811 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC12376789 OTO - NOTNLM OT - academic engagement OT - academic support OT - interpersonal relationships OT - physical activity OT - serial mediating model COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/08/27 20:46 MHDA- 2025/08/27 20:47 PMCR- 2025/08/11 CRDT- 2025/08/27 06:41 PHST- 2025/05/20 00:00 [received] PHST- 2025/07/28 00:00 [accepted] PHST- 2025/08/27 20:47 [medline] PHST- 2025/08/27 20:46 [pubmed] PHST- 2025/08/27 06:41 [entrez] PHST- 2025/08/11 00:00 [pmc-release] AID - 10.3389/fpsyg.2025.1632130 [doi] PST - epublish SO - Front Psychol. 2025 Aug 11;16:1632130. doi: 10.3389/fpsyg.2025.1632130. eCollection 2025. PMID- 40861061 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250914 LR - 20250914 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 13 DP - 2025 TI - Investigation of predictive factors for fatty liver in children and adolescents using artificial intelligence. PG - 1537098 LID - 10.3389/fped.2025.1537098 [doi] LID - 1537098 AB - BACKGROUND: Childhood obesity is a growing problem worldwide, leading to non-alcoholic fatty liver disease (NAFLD), which is the most common liver disease in children. Liver biopsy is the gold standard for NAFLD diagnosis. Machine learning algorithms could assist in an early diagnostic approach and leading to a favorable prognosis. OBJECTIVE: This study aimed to identify predictive factors for NAFLD in children and adolescents using machine learning models, focusing on liver biopsy outcomes such as fibrosis, infiltration, ballooning, and steatosis. METHODS: Data from 659 children suspected of NAFLD, who underwent liver biopsy at Mofid Children's Hospital between 2011 and 2023, were analyzed. The dataset included categorical and numerical variables, which were processed using one-hot encoding and standardization. Several machine learning models were trained and evaluated, including CatBoost, AdaBoost, Random Forest, and others. Model performance was assessed using cross-validation with accuracy, precision, recall, F1 score, and ROC-AUC metrics. Feature importance was determined through permutation analysis. RESULTS: Among NAFLD patients, the CatBoost Classifier achieved the highest accuracy (91.8%) and ROC-AUC score (92.3%) in cross-validation. In addition, the adjusted models showed better results. That is, the F1 for the CatBoost raised from 83% to 89% (AUC: 0.86-0.92), for the GradientBoosting from 76% to 81% (AUC: 0.81-0.85), and for Bernolli Naive Bayes from 78% to 82% (AUC: 0.82-0.85). CONCLUSION: Machine learning models, particularly CatBoost, demonstrated strong predictive capabilities for NAFLD diagnosis in children. CI - (c) 2025 Sayyari, Magsudy, Moeinipour, Hosseini, Amiri, Arzaghi, Sohrabivafa, Hamzavi, Azizi, Hatamii, Okhovat, Dara, Imanzadeh, Imanzadeh and Hajipour. FAU - Sayyari, Aliakbar AU - Sayyari A AD - Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Magsudy, Amin AU - Magsudy A AD - School of Medicine, Islamic Azad University, Tabriz Branch, Tabriz, Iran. FAU - Moeinipour, Yasamin AU - Moeinipour Y AD - Cardiovascular Surgery, Cardiothoracic Surgery Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Hosseini, Amirhossein AU - Hosseini A AD - Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Amiri, Hamidreza AU - Amiri H AD - Student Research Committee, Arak University of Medical Sciences, Arak, Iran. FAU - Arzaghi, Mohammadreza AU - Arzaghi M AD - Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Sohrabivafa, Fereshteh AU - Sohrabivafa F AD - Department of Community Medicine, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran. FAU - Hamzavi, Seyedeh Fatemeh AU - Hamzavi SF AD - School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Azizi, Ashkan AU - Azizi A AD - School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. FAU - Hatamii, Tahereh AU - Hatamii T AD - School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. FAU - Okhovat, AmirAli AU - Okhovat A AD - Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Dara, Naghi AU - Dara N AD - School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Imanzadeh, Negar AU - Imanzadeh N AD - School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Imanzadeh, Farid AU - Imanzadeh F AD - Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Hajipour, Mahmoud AU - Hajipour M AD - Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran. LA - eng PT - Journal Article DEP - 20250812 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC12377039 OTO - NOTNLM OT - CatBoost OT - NAFLD OT - childhood obesity OT - fibrosis OT - machine learning OT - predictive factors COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/08/27 20:46 MHDA- 2025/08/27 20:47 PMCR- 2025/08/12 CRDT- 2025/08/27 06:37 PHST- 2024/11/29 00:00 [received] PHST- 2025/06/19 00:00 [accepted] PHST- 2025/08/27 20:47 [medline] PHST- 2025/08/27 20:46 [pubmed] PHST- 2025/08/27 06:37 [entrez] PHST- 2025/08/12 00:00 [pmc-release] AID - 10.3389/fped.2025.1537098 [doi] PST - epublish SO - Front Pediatr. 2025 Aug 12;13:1537098. doi: 10.3389/fped.2025.1537098. eCollection 2025. PMID- 40861046 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250914 LR - 20250914 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 13 DP - 2025 TI - Clinical utility of FAI and SHBG in differentiating PCOS from anovulatory cycles in adolescent girls. PG - 1581060 LID - 10.3389/fped.2025.1581060 [doi] LID - 1581060 AB - INTRODUCTION: Menstrual irregularities are common in adolescents, often linked to anovulatory cycles. This study aims to establish diagnostic cut-off values for Polycystic Ovary Syndrome (PCOS) and differentiate it from anovulatory dysfunction in adolescents, while evaluating the diagnostic sensitivity of the Free Androgen Index (FAI) and Sex Hormone Binding Globulin (SHBG). METHODS: The study included 305 adolescents with oligomenorrhea at a tertiary center. Statistical analyses were performed, and Receiver Operating Characteristic (ROC) curves were used to assess diagnostic performance. RESULTS: Of the 305 patients, 229 (75%) had anovulatory cycles, and 36 (11.8%) were diagnosed with PCOS. Mean FAI values were 3.5 +/- 2 in anovulatory cycles, 8.0 +/- 5 in PCOS, and 8.3 +/- 4 in hyperinsulinism (p < 0.001). FAI showed significant positive correlations with HOMA-IR (r = 0.389, p < 0.001) and BMI z-score (r = 0.499, p < 0.001). ROC analysis identified an LH threshold of 9.7 U/L and an LH/FSH ratio of 2.62 as predictive markers for PCOS. DISCUSSION: Anovulatory cycles are the leading cause of menstrual irregularities in adolescents. While hyperandrogenism is crucial for PCOS diagnosis, elevated FAI levels in PCOS are also observed in hyperinsulinemia and obesity. PCOS is more prevalent in obese adolescents, which limits the diagnostic reliability of FAI. Lower SHBG levels in hyperinsulinemic obese adolescents further complicate FAI interpretation, underscoring the significant impact of glucose and insulin metabolism on these markers. Therefore, a comprehensive diagnostic approach, including androgen levels, LH/FSH ratio, SHBG, FAI, and ovarian ultrasound, is essential for accurate PCOS diagnosis in adolescent girls. CI - (c) 2025 Ozer, Tas, Cakir Gundogan, Boyraz and Gurbuz. FAU - Ozer, Emre AU - Ozer E AD - Department of Pediatric Endocrinology, Ankara Bilkent City Hospital, Ankara, Turkiye. FAU - Tas, Demet AU - Tas D AD - Department of Pediatrics, Division of Adolescent Health, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Turkiye. AD - Division of Adolescent Health, Department of Pediatrics, Ankara Bilkent City Hospital, Ankara, Turkiye. FAU - Cakir Gundogan, Secil AU - Cakir Gundogan S AD - Department of Pediatric Endocrinology, Ankara Bilkent City Hospital, Ankara, Turkiye. FAU - Boyraz, Mehmet AU - Boyraz M AD - Department of Pediatric Endocrinology, Ankara Bilkent City Hospital, Ankara, Turkiye. AD - Department of Pediatric Endocrinology, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Turkiye. FAU - Gurbuz, Fatih AU - Gurbuz F AD - Department of Pediatric Endocrinology, Ankara Bilkent City Hospital, Ankara, Turkiye. AD - Department of Pediatric Endocrinology, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20250808 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC12370747 OTO - NOTNLM OT - LH-FSH OT - free androgen index OT - menstrual irregularity OT - oligomenorrhea OT - polycystic ovary syndrome OT - sex hormone binding globuline COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/08/27 20:46 MHDA- 2025/08/27 20:47 PMCR- 2025/08/08 CRDT- 2025/08/27 06:37 PHST- 2025/02/21 00:00 [received] PHST- 2025/07/21 00:00 [accepted] PHST- 2025/08/27 20:47 [medline] PHST- 2025/08/27 20:46 [pubmed] PHST- 2025/08/27 06:37 [entrez] PHST- 2025/08/08 00:00 [pmc-release] AID - 10.3389/fped.2025.1581060 [doi] PST - epublish SO - Front Pediatr. 2025 Aug 8;13:1581060. doi: 10.3389/fped.2025.1581060. eCollection 2025. PMID- 40853659 OWN - NLM STAT- MEDLINE DCOM- 20250826 LR - 20260714 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 8 IP - 8 DP - 2025 Aug 1 TI - Parent-Reported Obesogenic Risk Behaviors and Infant Weight at Age 6 Months. PG - e2528689 LID - 10.1001/jamanetworkopen.2025.28689 [doi] LID - e2528689 AB - IMPORTANCE: Parents influence young children's diet, sleep, and physical activity behaviors. Pediatric primary care practitioners (PCPs) are uniquely positioned to identify obesogenic behaviors from infancy, yet few screening tools assess these behaviors in clinical settings. OBJECTIVE: To explore the association between parent-reported obesogenic behaviors and infant weight outcomes. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study is a secondary analysis of data from the Women, Infants, and Children Enhancements to Early Healthy Lifestyles for Baby (WEE Baby) Care study. Participants were recruited from the Geisinger Health System in northeastern Pennsylvania between July 6, 2016, and April 30, 2018. Mothers aged 18 years or older were eligible if their infant was enrolled in the Special Supplemental Nutrition Program for Women, Infants, and Children and who completed the Early Healthy Lifestyles (EHL) screening tool at infant age 2 months and had available infant growth data at 6 months. The analysis was completed on June 8, 2025. EXPOSURE: The 15-item parent-reported EHL tool assessing infant diet, mothers' feeding practices, infant sleep, interactive play, and appetitive traits. MAIN OUTCOMES AND MEASURES: Infant weight and length were measured at well-child visits. The primary outcomes were body mass index (BMI) and weight-for-length (WFL) z scores at infant age 6 months. RESULTS: Among 143 mother-infant dyads (median [IQR] maternal age, 26.5 [23.0-31.1] years; infant mean [SD] gestational age, 39.5 [1.2] weeks; 77 boys [53.8%]), the EHL tool identified 9 behaviors associated with higher BMI and WFL z scores at infant age 6 months, including developmentally inappropriate bottle size, nighttime feeding, putting the infants to bed after 8:00 pm, frequent night wakes, television on in the room where the infant sleeps, putting the infant to bed already asleep instead of drowsy but awake, limited active play or tummy time, using a cell phone or television while playing, and mothers' perception of the infant always being hungry. Higher composite scores were significantly associated with higher BMI z score (beta = 0.22; 95% CI, 0.10-0.34) and WFL z score (beta = 0.21; 95% CI, 0.09-0.33) at 6 months. CONCLUSIONS AND RELEVANCE: These findings show that the EHL screening tool, which identifies modifiable obesogenic behaviors, is associated with early-life weight outcomes. Validating this tool requires testing in clinical and community settings for early childhood obesity prevention. FAU - Ma, Yining AU - Ma Y AD - Center for Childhood Obesity Research, The Pennsylvania State University, University Park. AD - Department of Nutritional Sciences, The Pennsylvania State University, University Park. FAU - Bailey-Davis, Lisa AU - Bailey-Davis L AD - Population Health Sciences, Center for Obesity and Metabolic Research, Geisinger College of Health Sciences, Danville, Pennsylvania. FAU - Fisher, Zachary F AU - Fisher ZF AD - Department of Human Development and Family Studies, The Pennsylvania State University, University Park. FAU - Moore, Amy M AU - Moore AM AD - Center for Childhood Obesity Research, The Pennsylvania State University, University Park. AD - Department of Nutritional Sciences, The Pennsylvania State University, University Park. FAU - Savage, Jennifer S AU - Savage JS AD - Center for Childhood Obesity Research, The Pennsylvania State University, University Park. AD - Department of Nutritional Sciences, The Pennsylvania State University, University Park. LA - eng PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20250801 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Humans MH - Female MH - Infant MH - Male MH - Cross-Sectional Studies MH - Adult MH - *Pediatric Obesity/epidemiology MH - Body Mass Index MH - Pennsylvania MH - *Body Weight MH - Feeding Behavior MH - Sleep MH - *Parents/psychology MH - Mothers MH - Exercise PMC - PMC12379087 COIS- Conflict of Interest Disclosures: None reported. EDAT- 2025/08/27 04:45 MHDA- 2025/08/27 04:46 PMCR- 2025/08/25 CRDT- 2025/08/25 11:56 PHST- 2025/08/27 04:46 [medline] PHST- 2025/08/27 04:45 [pubmed] PHST- 2025/08/25 11:56 [entrez] PHST- 2025/08/25 00:00 [pmc-release] AID - 2837959 [pii] AID - zoi250803 [pii] AID - 10.1001/jamanetworkopen.2025.28689 [doi] PST - epublish SO - JAMA Netw Open. 2025 Aug 1;8(8):e2528689. doi: 10.1001/jamanetworkopen.2025.28689. PMID- 40856364 OWN - NLM STAT- MEDLINE DCOM- 20251030 LR - 20260127 IS - 1475-2662 (Electronic) IS - 0007-1145 (Print) IS - 0007-1145 (Linking) VI - 134 IP - 5 DP - 2025 Sep 14 TI - Relative validity of food and nutrient intakes derived from a brief-type diet history questionnaire for Japanese children and adolescents. PG - 425-439 LID - 10.1017/S0007114525104042 [doi] AB - The aim of this study was to evaluate the relative validity of food and nutrient intakes estimated by a brief-type diet history questionnaire for Japanese children and adolescents (BDHQ15y) designed to assess habitual dietary intake during the previous month. A total of 432 boys and 412 girls aged 6-17 years from thirty-two prefectures in Japan completed the BDHQ15y and subsequently provided 8-day weighed dietary records (DR) on two non-consecutive days over four seasons for comparison. Among the intakes of forty-four nutrients and thirty-one food groups adjusted for energy intake using the density model, the BDHQ15y showed percentage differences in median intake of less than 10 % compared with the DR for nineteen nutrients in both sexes, as well as for eleven and seven food groups in boys and girls, respectively, indicating good agreement for key nutrients and food groups, including protein, fat, carbohydrate, dietary fibre, grains, vegetables, dairy products and sugar-sweetened beverages (SSB). The median values (25th-75th percentiles) of Spearman's correlation coefficients in boys and girls were 0.33 (0.28-0.38) and 0.28 (0.23-0.35) for nutrients, respectively, and 0.36 (0.29-0.42) and 0.29 (0.24-0.36) for food groups, respectively. Bland-Altman plots showed wide limits of agreement, with overestimation at higher intakes for most nutrients and food groups, except SSB. In conclusion, the BDHQ15y shows promise for large-scale dietary monitoring, particularly for estimating group-level intakes of key nutrients and food groups. However, its limited ability to rank individual intakes and the variability in individual-level assessments necessitate cautious interpretation and application. FAU - Okubo, Hitomi AU - Okubo H AUID- ORCID: 0000-0002-2305-0719 AD - Department of Nutritional Epidemiology and Behavioural Nutrition, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo113-0033, Japan. FAU - Tajima, Ryoko AU - Tajima R AD - Department of Nutritional Epidemiology and Behavioural Nutrition, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo113-0033, Japan. FAU - Shinozaki, Nana AU - Shinozaki N AUID- ORCID: 0000-0002-8998-5066 AD - Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo113-0033, Japan. FAU - Masayasu, Shizuko AU - Masayasu S AD - Ikurien-Naka, 3799-6 Sugaya, Naka-shi, Ibaraki311-0105, Japan. FAU - Sasaki, Satoshi AU - Sasaki S AUID- ORCID: 0000-0002-5927-2364 AD - Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo113-0033, Japan. FAU - Murakami, Kentaro AU - Murakami K AUID- ORCID: 0000-0002-4189-7753 AD - Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo113-0033, Japan. LA - eng PT - Journal Article PT - Validation Study DEP - 20250826 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 RN - 0 (Nutrients) RN - Japanese people SB - IM MH - Humans MH - Female MH - Child MH - Male MH - Adolescent MH - Japan MH - *Diet MH - Diet Records MH - Surveys and Questionnaires MH - *Nutrients/administration & dosage MH - *Diet Surveys MH - Energy Intake MH - Reproducibility of Results MH - Feeding Behavior MH - Nutrition Assessment MH - East Asian People PMC - PMC12580970 OTO - NOTNLM OT - Adolescents OT - Children OT - Diet history questionnaire OT - Food group intake OT - Nutrient intake OT - Relative validity EDAT- 2025/08/26 12:44 MHDA- 2025/10/30 12:28 PMCR- 2025/11/03 CRDT- 2025/08/26 08:15 PHST- 2025/10/30 12:28 [medline] PHST- 2025/08/26 12:44 [pubmed] PHST- 2025/08/26 08:15 [entrez] PHST- 2025/11/03 00:00 [pmc-release] AID - S0007114525104042 [pii] AID - 10.1017/S0007114525104042 [doi] PST - ppublish SO - Br J Nutr. 2025 Sep 14;134(5):425-439. doi: 10.1017/S0007114525104042. Epub 2025 Aug 26. PMID- 40854681 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260711 IS - 1945-7049 (Electronic) IS - 1061-3749 (Linking) VI - 34 IP - 2 DP - 2026 Jul 10 TI - Turkish Validity and Reliability Study of the Youth Physical Activity Attitude Scale. PG - 212-218 LID - 10.1891/JNM-2025-0011 [doi] AB - Background and Purpose: The purpose of the research is to assess the validity and reliability of the Youth Physical Activity Attitude Scale in Turkish. Methods: This study was conducted with 320 children aged 9 to 14 in a province in eastern Turkey between March and June 2022. The scale consisted of four factors and 23 items responded on a 3-point Likert scale. No items were removed from the scale during content validity. Results: Confirmatory factor analysis showed that the model fit was within acceptable criteria, and the factor structure was the same as the original one. Coefficient alpha values were .85 for the total scale, .80 for the positive attitude sub-scale, and .68 for the negative attitudes sub-scale. Conclusions: The Turkish version of the scale was found to be valid and reliable. CI - (c) 2026 Springer Publishing Company. FAU - Savci Bakan, Ayse Berivan AU - Savci Bakan AB AD - School of Health, Department of Nursing, Agri Ibrahim Cecen University, Agri, Turkey. FAU - Aslan, Gulpinar AU - Aslan G AD - School of Health, Department of Midwifery, Agri Ibrahim Cecen University, Agri, Turkey pinar_goksuguzel@hotmail.com. LA - eng PT - Journal Article PT - Validation Study DEP - 20260710 PL - United States TA - J Nurs Meas JT - Journal of nursing measurement JID - 9318902 SB - IM MH - Humans MH - Turkey MH - Child MH - Reproducibility of Results MH - Female MH - Male MH - Adolescent MH - *Psychometrics/standards MH - Surveys and Questionnaires/standards MH - *Exercise/psychology MH - Factor Analysis, Statistical MH - *Attitude to Health OTO - NOTNLM OT - attitude OT - child OT - physical activity OT - reliability OT - scale OT - validity EDAT- 2025/08/26 00:45 MHDA- 2026/07/12 00:54 CRDT- 2025/08/25 21:03 PHST- 2026/07/12 00:54 [medline] PHST- 2025/08/26 00:45 [pubmed] PHST- 2025/08/25 21:03 [entrez] AID - JNM-2025-0011 [pii] AID - 10.1891/JNM-2025-0011 [doi] PST - epublish SO - J Nurs Meas. 2026 Jul 10;34(2):212-218. doi: 10.1891/JNM-2025-0011. PMID- 40849339 OWN - NLM STAT- MEDLINE DCOM- 20250823 LR - 20250827 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Aug 23 TI - Adaptation and validation of the Indonesian version of the early feeding skill assessment tool for low birth weight infants. PG - 31028 LID - 10.1038/s41598-025-15342-9 [doi] LID - 31028 AB - Initiating oral feeding at inappropriate times can cause stress and complications for Low Birth Weight (LBW) infants. It is essential to assess the infant's readiness for oral feeding to minimize stress and support the transition to full oral feeding. An objective assessment tool is necessary to improve the accuracy of determining the right time to start oral feedings. This study aimed to translate, adapt, and psychometrically validate the original English version of the Early Feeding Skill Assessment Tool (EFS) into the Indonesian language. The EFS questionnaire, an observation instrument with 19 items, uses a 3-option scoring structure: not yet evident, emerging, or consistently observed. The following EFS adaptation phases: (1) forward translation; (2) synthesis of forward translation; (3) back translation; (4) harmonization of the original and back translation; (4) pre-testing with the expert committee for content and relevance; (5) pre-testing with target user population for clarity; and (6) field testing. The translation was carried out by a certified translator in conjunction with a bilingual health professional. Seven neonatal experts participated in the pre-testing phase, while six nurses engaged with the target population for further evaluation. A total of 128 observations were conducted on infants exhibiting stable hemodynamics during the field testing phase. The two forward translations differed in 12 items, leading to expert discussions and consensus on the translation. The pre-testing among seven expert for content validity showed The EFS I-CVI and S-CVI/ave were 1 for all questions, indicating full expert agreement. The pre-testing among six nurses for face validity showed clear instructions (93%), with question agreement ranging from 60 to 100%. Six items had < 80% agreement and were rewritten as suggest from nurses. In field testing from 128 observations among 52 LBW infants revealed 19 items were valid and their reliability was 0.918. The 19-item EFS Indonesian version is valid and reliable for LBW infants. It can be used to implement as an assessment for a common language for infant feeding skills among interprofessional teams, contributing to infant feeding success. CI - (c) 2025. The Author(s). FAU - Hariati, Suni AU - Hariati S AD - Pediatrics Nursing Department, Faculty of Nursing, Hasanuddin University, Makassar City, 90245, Indonesia. sunihariati@unhas.ac.id. FAU - Erfina, Erfina AU - Erfina E AD - Maternity Nursing Department, Faculty of Nursing, Hasanuddin University, Makassar City, 90245, Indonesia. FAU - Febriani, Andi Dwi Bahagia AU - Febriani ADB AD - Department of Pediatrics, Faculty of Medicine, Hasanuddin University, Makassar City, 90245, Indonesia. FAU - Alasiry, Ema AU - Alasiry E AD - Department of Pediatrics, Faculty of Medicine, Hasanuddin University, Makassar City, 90245, Indonesia. FAU - Asriaty, Asriaty AU - Asriaty A AD - Neonatal Intensive Care Unit, Wahidin Sudirohusodo Hospital, Makassar City, 90245, Indonesia. FAU - Haerani, Haerani AU - Haerani H AD - Pediatric Nursing Department, Panrita Husada Health School, Bulukumba District, 92561, Indonesia. LA - eng PT - Journal Article PT - Validation Study DEP - 20250823 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Indonesia MH - Infant, Newborn MH - Female MH - Male MH - *Infant, Low Birth Weight/physiology MH - Psychometrics MH - Surveys and Questionnaires MH - Infant MH - Translations MH - *Feeding Behavior MH - Reproducibility of Results MH - *Breast Feeding PMC - PMC12375095 OTO - NOTNLM OT - Feeding behavior OT - Instruments OT - Low birth weight OT - Premature infants OT - Psychometrics COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval: The study received approval from the Ethical Review Board of the Faculty of Nursing at Hasanuddin University in Indonesia (No.691/UN4.18.3/TP.01.02/2024). All participants gave written informed consent before the data collection began. Enumerators collected all questionnaires anonymously. The data is securely stored and will only be used for research purposes. EDAT- 2025/08/26 04:47 MHDA- 2025/08/26 04:48 PMCR- 2025/08/23 CRDT- 2025/08/23 23:18 PHST- 2024/12/17 00:00 [received] PHST- 2025/08/07 00:00 [accepted] PHST- 2025/08/26 04:48 [medline] PHST- 2025/08/26 04:47 [pubmed] PHST- 2025/08/23 23:18 [entrez] PHST- 2025/08/23 00:00 [pmc-release] AID - 10.1038/s41598-025-15342-9 [pii] AID - 15342 [pii] AID - 10.1038/s41598-025-15342-9 [doi] PST - epublish SO - Sci Rep. 2025 Aug 23;15(1):31028. doi: 10.1038/s41598-025-15342-9. PMID- 40847396 OWN - NLM STAT- MEDLINE DCOM- 20250823 LR - 20250827 IS - 1477-7827 (Electronic) IS - 1477-7827 (Linking) VI - 23 IP - 1 DP - 2025 Aug 22 TI - Lifestyle in flux: urbanization, dietary shifts, and endocrine health in emerging adulthood. PG - 118 LID - 10.1186/s12958-025-01442-8 [doi] LID - 118 AB - Emerging evidence highlights the decline of testosterone levels among young males, linked to modern lifestyle shifts rather than aging alone. This exploratory cross-sectional study investigates the interplay between modifiable lifestyle factors and testosterone levels in 50 males aged 18-22 years, focusing on underrepresented variables such as exercise type, carbonated beverage intake, and sunlight exposure. Serum testosterone levels were measured via chemiluminescent immunoassay, and lifestyle data were collected through previously validated questionnaires. Multiple regression analyses revealed hypertrophy training (beta = 20.3, p < 0.001), sunlight exposure > 60 min (beta = 10.3, p = 0.03), and supplement use (beta = 20.5, p < 0.001) as positive predictors of testosterone. Conversely, daily carbonated beverage consumption (beta=-10.2, p = 0.01), tobacco use (beta=-15.6, p < 0.001), and sleep deprivation (beta=-18.2, p < 0.001) were significant negative correlates. Diet type influenced outcomes, with non-vegetarians showing higher testosterone (beta = 8.7, p = 0.03) compared to vegetarians. Notably, BMI and chronic diseases were nonsignificant in this young cohort. These findings underscore the multifactorial nature of testosterone regulation, emphasizing holistic lifestyle interventions-such as resistance training, reduced ultra-processed food intake, and sleep optimization-as critical for endocrine health in urbanized youth. The study challenges traditional obesity-centric frameworks, advocating for holistic approaches to mitigate endocrine disruption in emerging adulthood. CI - (c) 2025. The Author(s). FAU - Joshi, Om Vijay AU - Joshi OV AD - Department of Biotechnology, Institute of Biosciences and Technology, MGM University, Chhatrapati Sambhajinagar (Aurangabad), 431006, MH, India. FAU - Savale, Ronit Rohidas AU - Savale RR AD - Department of Biotechnology, Institute of Biosciences and Technology, MGM University, Chhatrapati Sambhajinagar (Aurangabad), 431006, MH, India. FAU - Nalage, Dinesh AU - Nalage D AD - Department of Biotechnology, Maulana Azad College of Arts, Science & Commerce, Chhatrapati Sambhajinagar (Aurangabad), 431001, MH, India. nalagedineshn@gmail.com. FAU - Biradar, Ashwini AU - Biradar A AD - Department of Microbiology, Dr. Babasaheb Ambedkar Marathwada University, Sub Campus Osmanabad, Osmanabad, 413501, MH, India. FAU - Sontakke, Tejswini AU - Sontakke T AD - Department of Zoology, MGV's, MPH Mahila Mahavidyalaya, Malegaon, 423203, Dist. Nashik, MH, India. LA - eng PT - Journal Article DEP - 20250822 PL - England TA - Reprod Biol Endocrinol JT - Reproductive biology and endocrinology : RB&E JID - 101153627 RN - 3XMK78S47O (Testosterone) SB - IM MH - Humans MH - Male MH - Adolescent MH - Young Adult MH - *Life Style MH - Cross-Sectional Studies MH - *Testosterone/blood MH - *Urbanization/trends MH - *Diet/trends MH - Exercise/physiology MH - Sunlight PMC - PMC12372347 OTO - NOTNLM OT - Endocrine disruptors OT - Lifestyle factors OT - Resistance training OT - Testosterone levels OT - Young adult males COIS- Declarations. Ethical approval and consent to participate: This study was conducted in accordance with the principles outlined in the Declaration of Helsinki. Ethical approval was obtained from the Institutional Ethics Committee of MGM- Ethical Committee for Research on Human Subject (MGM- ECRHS), Aurangabad (approval number: MGM-ECRHS/2023/145, date: 6/10/2023). Prior to participation, written informed consent was obtained from all study participants after explaining the study objectives, procedures, risks, and benefits. Participants were informed of their right to withdraw from the study at any point without penalty. Confidentiality of participant data was maintained throughout the study period and during analysis. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. Clinical trial number: Not applicable. EDAT- 2025/08/26 04:45 MHDA- 2025/08/26 04:46 PMCR- 2025/08/22 CRDT- 2025/08/23 00:39 PHST- 2025/03/31 00:00 [received] PHST- 2025/07/09 00:00 [accepted] PHST- 2025/08/26 04:46 [medline] PHST- 2025/08/26 04:45 [pubmed] PHST- 2025/08/23 00:39 [entrez] PHST- 2025/08/22 00:00 [pmc-release] AID - 10.1186/s12958-025-01442-8 [pii] AID - 1442 [pii] AID - 10.1186/s12958-025-01442-8 [doi] PST - epublish SO - Reprod Biol Endocrinol. 2025 Aug 22;23(1):118. doi: 10.1186/s12958-025-01442-8. PMID- 40843744 OWN - NLM STAT- MEDLINE DCOM- 20250822 LR - 20260703 IS - 2076-3271 (Electronic) IS - 2076-3271 (Linking) VI - 13 IP - 3 DP - 2025 Aug 11 TI - Sociodemographic Factors, Healthy Habits, and Quality of Life in Relation to Insulin Resistance Risk in a Large Cohort of Spanish Workers. LID - 10.3390/medsci13030122 [doi] LID - 122 AB - Background: Insulin resistance (IR) is a key pathogenic mechanism underlying numerous cardiometabolic disorders. While sociodemographic and lifestyle determinants of IR are well-established, their association with health-related quality of life (HRQoL) remains understudied. This study explores the relationship between IR risk, as measured by TyG, METS-IR, and SPISE-IR indices, and HRQoL in a large cohort of Spanish workers. Methods: This cross-sectional study included 100,014 Spanish workers aged 18-69 years evaluated between January 2021 and December 2023. Exclusion criteria included incomplete clinical, laboratory, or questionnaire data. IR was assessed using TyG, METS-IR, and SPISE-IR indices. HRQoL was measured using the SF-12 questionnaire. Sociodemographic factors, physical activity (IPAQ), dietary habits (MEDAS-14), and social class (based on CNAE-11 and Spanish Society of Epidemiology criteria) were also evaluated. Statistical analysis was conducted using SPSS v29.0. Results: Higher IR risk was consistently associated with older age, male sex, lower social class, current smoking, low adherence to the Mediterranean diet, and physical inactivity. Lower HRQoL scores (both physical and mental components) were significantly associated with higher IR indices, particularly with METS-IR and SPISE-IR. These associations persisted after adjusting for sociodemographic and behavioral covariates. Conclusions: This study demonstrates a robust association between insulin resistance risk and diminished health-related quality of life. The integration of validated IR indices and subjective health perception tools such as the SF-12 may enhance early identification of at-risk individuals in occupational health settings. FAU - Marzoa Jansana, Maria Dolores AU - Marzoa Jansana MD AD - ADEMA-Health Group, University Institute for Research in Health Sciences (IUNICS), 07010 Palma, Spain. FAU - Tarraga Lopez, Pedro Juan AU - Tarraga Lopez PJ AUID- ORCID: 0000-0002-5222-5784 AD - Faculty of Medicine, UCLM (University of Castilla La Mancha), 02008 Albacete, Spain. FAU - Guarro Miquel, Juan Jose AU - Guarro Miquel JJ AD - ADEMA-Health Group, University Institute for Research in Health Sciences (IUNICS), 07010 Palma, Spain. FAU - Lopez-Gonzalez, Angel Arturo AU - Lopez-Gonzalez AA AUID- ORCID: 0000-0002-7439-8117 AD - ADEMA-Health Group, University Institute for Research in Health Sciences (IUNICS), 07010 Palma, Spain. AD - Faculty of Dentistry, ADEMA-Universidad de las Islas Baleares, 07010 Palma, Spain. AD - Balearic Islands Health Research Institute Foundation (IDISBA), 07010 Palma, Spain. AD - Balearic Islands Health Service, 07010 Palma, Spain. FAU - Riutord Sbert, Pere AU - Riutord Sbert P AUID- ORCID: 0000-0003-2135-9699 AD - ADEMA-Health Group, University Institute for Research in Health Sciences (IUNICS), 07010 Palma, Spain. AD - Faculty of Dentistry, ADEMA-Universidad de las Islas Baleares, 07010 Palma, Spain. FAU - Busquets-Cortes, Carla AU - Busquets-Cortes C AUID- ORCID: 0000-0001-9367-2137 AD - ADEMA-Health Group, University Institute for Research in Health Sciences (IUNICS), 07010 Palma, Spain. AD - Balearic Islands Health Research Institute Foundation (IDISBA), 07010 Palma, Spain. FAU - Ramirez-Manent, Jose Ignacio AU - Ramirez-Manent JI AUID- ORCID: 0000-0001-6887-4562 AD - ADEMA-Health Group, University Institute for Research in Health Sciences (IUNICS), 07010 Palma, Spain. AD - Balearic Islands Health Research Institute Foundation (IDISBA), 07010 Palma, Spain. AD - Balearic Islands Health Service, 07010 Palma, Spain. AD - Faculty of Medicine, University of the Balearic Islands, 07010 Palma, Spain. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250811 PL - Switzerland TA - Med Sci (Basel) JT - Medical sciences (Basel, Switzerland) JID - 101629322 SB - IM MH - Humans MH - Male MH - Adult MH - *Insulin Resistance/physiology MH - Female MH - Middle Aged MH - *Quality of Life MH - Spain/epidemiology MH - Cross-Sectional Studies MH - Aged MH - Young Adult MH - Adolescent MH - Risk Factors MH - Sociodemographic Factors MH - Exercise MH - Cohort Studies MH - Surveys and Questionnaires PMC - PMC12371977 OTO - NOTNLM OT - METS-IR OT - TyG OT - insulin resistance OT - life style OT - quality of life OT - socioeconomic variables COIS- The authors declare no conflicts of interest-financial or otherwise-related to the conception, execution, analysis, or dissemination of this study. EDAT- 2025/08/26 04:46 MHDA- 2025/08/26 04:47 PMCR- 2025/08/11 CRDT- 2025/08/22 06:43 PHST- 2025/07/27 00:00 [received] PHST- 2025/08/07 00:00 [revised] PHST- 2025/08/09 00:00 [accepted] PHST- 2025/08/26 04:47 [medline] PHST- 2025/08/26 04:46 [pubmed] PHST- 2025/08/22 06:43 [entrez] PHST- 2025/08/11 00:00 [pmc-release] AID - medsci13030122 [pii] AID - medsci-13-00122 [pii] AID - 10.3390/medsci13030122 [doi] PST - epublish SO - Med Sci (Basel). 2025 Aug 11;13(3):122. doi: 10.3390/medsci13030122. PMID- 40839120 OWN - NLM STAT- MEDLINE DCOM- 20250821 LR - 20251210 IS - 1436-6215 (Electronic) IS - 1436-6207 (Print) IS - 1436-6207 (Linking) VI - 64 IP - 6 DP - 2025 Aug 21 TI - Correlates of adherence to the Mediterranean diet among preschool-age and school-age children living in Mediterranean countries: a systematic review. PG - 264 LID - 10.1007/s00394-025-03769-9 [doi] LID - 264 AB - PURPOSE: In recent years, children in Mediterranean countries have shown low adherence to Mediterranean Diet (MD) with a shift toward a Western diet. This study aims to understand the reasons behind moving away from the MD among children, by providing an overview of the different correlates influencing MD adherence among preschool and school-age children (3-8 years old). METHODS: A systematic review was conducted and reported in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines and registered in the Prospero database (CRD42023370607). Literature was searched in PubMed, Web of Science and PsycINFO databases for studies, without restrictions on publication date. Inclusion criteria were preschool and school-aged children, studies conducted in Mediterranean countries, and statistical analyses of the association between the different correlates and MD adherence quantified by a validated dietary assessment. Studies that did not provide sub-analyses for the specified age group were excluded. A quality analysis of the included studies was performed using the National Collaborating Centre for Methods and Tools (NCCMT) scale. RESULTS: A total of 12 studies were included, primarily from European Mediterranean countries, with fewer studies from the Middle East and North Africa. The vast majority of the included studies reported on interpersonal correlates related to the parent's influence on MD adherence, while child's age and sex, physical activity, and time spent on video games were classified as individual, and only the place of residence was classified as an environmental correlate. The quality assessment generally showed weak scores. CONCLUSION: The primary factors influencing MD were interpersonal correlates related to parents, indicating that interventions should target both children and parents to effectively reinforce MD adherence. CI - (c) 2025. The Author(s). FAU - Trezia, Nancy AU - Trezia N AUID- ORCID: 0009-0008-8095-8257 AD - Faculty of Nursing and Health Sciences, Notre Dame University-Louaize (NDU), Zouk Mosbeh, Lebanon. FAU - Obeid, Cecile AU - Obeid C AUID- ORCID: 0000-0001-9538-282X AD - Department of Health Promotion, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, PO Box 616, 6200 MD, Maastricht, The Netherlands. cecile.obeid.hendieh@gmail.com. FAU - Abou Jaoude, Maya AU - Abou Jaoude M AD - Faculty of Nursing and Health Sciences, Notre Dame University-Louaize (NDU), Zouk Mosbeh, Lebanon. FAU - Gubbels, Jessica AU - Gubbels J AUID- ORCID: 0000-0002-9284-1725 AD - Department of Health Promotion, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, PO Box 616, 6200 MD, Maastricht, The Netherlands. FAU - Mazloum, Clara AU - Mazloum C AD - Faculty of Nursing and Health Sciences, Notre Dame University-Louaize (NDU), Zouk Mosbeh, Lebanon. FAU - Aoun, Antoine AU - Aoun A AD - Faculty of Nursing and Health Sciences, Notre Dame University-Louaize (NDU), Zouk Mosbeh, Lebanon. AD - Center for Obesity Prevention Treatment Education and Research (COPTER), Notre Dame University-Louaize (NDU), Zouk Mosbeh, Lebanon. FAU - El Hayek Fares, Jessy AU - El Hayek Fares J AD - Faculty of Nursing and Health Sciences, Notre Dame University-Louaize (NDU), Zouk Mosbeh, Lebanon. LA - eng PT - Journal Article PT - Systematic Review DEP - 20250821 PL - Germany TA - Eur J Nutr JT - European journal of nutrition JID - 100888704 SB - IM MH - Humans MH - *Diet, Mediterranean/statistics & numerical data MH - Child MH - Child, Preschool MH - Mediterranean Region MH - Male MH - Female MH - *Patient Compliance/statistics & numerical data PMC - PMC12370561 OTO - NOTNLM OT - Adherence OT - Children OT - Correlates OT - Mediterranean diet COIS- Declarations. Conflict of interest: The authors have no relevant interests to declare. EDAT- 2025/08/26 04:44 MHDA- 2025/08/26 04:45 PMCR- 2025/08/21 CRDT- 2025/08/21 11:13 PHST- 2024/07/31 00:00 [received] PHST- 2025/07/13 00:00 [accepted] PHST- 2025/08/26 04:45 [medline] PHST- 2025/08/26 04:44 [pubmed] PHST- 2025/08/21 11:13 [entrez] PHST- 2025/08/21 00:00 [pmc-release] AID - 10.1007/s00394-025-03769-9 [pii] AID - 3769 [pii] AID - 10.1007/s00394-025-03769-9 [doi] PST - epublish SO - Eur J Nutr. 2025 Aug 21;64(6):264. doi: 10.1007/s00394-025-03769-9. PMID- 40854072 OWN - NLM STAT- MEDLINE DCOM- 20251224 LR - 20260714 IS - 1939-3806 (Electronic) IS - 1939-3806 (Linking) VI - 18 IP - 12 DP - 2025 Dec TI - The National Prevalence of Neurodevelopmental Disorders and Their Associations With Health Conditions Among General Junior High School Students in China: Findings From the China Education Panel Survey. PG - 2538-2547 LID - 10.1002/aur.70111 [doi] AB - Neurodevelopmental disorders (NDDs) remain poorly understood in adolescents, particularly in middle-income countries like China. To assess NDDs prevalence and their associations with health conditions among Chinese general junior high school students, data from the China Education Panel Survey (CEPS, 2013-2015) were used. A total of 8324 junior high school students were included. Validated questionnaires and tests assessed NDDs (autism spectrum disorder [ASD], language disorder [LD], and attention-deficit/hyperactivity disorder [ADHD]) and health conditions (physical health through overweight/obesity and myopia; mental health through anxiety symptoms and depression symptoms; cognitive functioning through academic performance and cognitive ability; adherence to social norms). Of 8324 participants, 299 (4.59%) had NDDs. Students with NDDs showed higher rates of anxiety symptoms and poor cognitive ability compared to those without NDDs. Specific NDD associations included anxiety symptoms with LD and ADHD, depression symptoms with ASD and ADHD, and poor cognitive ability with ASD and LD. Sex-specific disparities were observed in the associations: the link between NDDs and depression symptoms was evident solely in boys, whereas the association between NDDs and academic performance was significant only in girls. Increased surveillance of NDDs prevalence nationwide and improved support services through better integration of families, schools, and society are needed. CI - (c) 2025 International Society for Autism Research and Wiley Periodicals LLC. FAU - Shen, Shu-Li AU - Shen SL AD - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, China. FAU - Pan, Ning AU - Pan N AUID- ORCID: 0000-0002-1492-0612 AD - Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, Institute for Brain Research and Rehabilitation, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, China. FAU - Lin, Jun-Shan AU - Lin JS AD - Guangzhou Civil Aviation College, Guangzhou, China. FAU - Chen, Ying-Qian AU - Chen YQ AUID- ORCID: 0000-0002-5924-5593 AD - Department of Radiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. FAU - Lin, Li-Zi AU - Lin LZ AD - Department of Occupational and Environmental Health, Joint International Research Laboratory of Environment and Health, Ministry of Education, Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, School of Public Health, Sun Yat-sen University, Guangzhou, China. FAU - Cai, Li AU - Cai L AD - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, China. FAU - Liu, Zhao-Yan AU - Liu ZY AD - Department of Nutrition, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China. FAU - Feng, Qiang AU - Feng Q AD - Department of Fitness Surveillance Centre, China Institute of Sport Science, Beijing, China. FAU - Jing, Jin AU - Jing J AD - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, China. FAU - Wang, Xin AU - Wang X AUID- ORCID: 0000-0001-6098-6500 AD - Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, Institute for Brain Research and Rehabilitation, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, China. LA - eng GR - 2022B1515130007/Basic and Applied Basic Research Foundation of Guangdong Province/ GR - 2023A1515110220/Basic and Applied Basic Research Foundation of Guangdong Province/ GR - 2024A1515011820/Basic and Applied Basic Research Foundation of Guangdong Province/ GR - 2025A1515010685/Basic and Applied Basic Research Foundation of Guangdong Province/ GR - 2019B030335001/Key-Area Research and Development Program of Guangdong Province/ GR - 2120001008276/Social-Area Science and Technology Research Program of Foshan City/ GR - 82103794/National Natural Science Foundation of China/ GR - 81973063/National Natural Science Foundation of China/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250825 PL - United States TA - Autism Res JT - Autism research : official journal of the International Society for Autism Research JID - 101461858 SB - IM MH - Humans MH - China/epidemiology MH - Female MH - Male MH - Adolescent MH - Prevalence MH - *Neurodevelopmental Disorders/epidemiology MH - *Students/statistics & numerical data MH - Surveys and Questionnaires MH - *Health Status MH - Depression/epidemiology MH - Anxiety/epidemiology MH - Academic Performance OTO - NOTNLM OT - China OT - adolescents OT - health conditions OT - neurodevelopmental disorders OT - prevalence EDAT- 2025/08/25 20:45 MHDA- 2025/12/24 12:54 CRDT- 2025/08/25 14:22 PHST- 2025/07/27 00:00 [revised] PHST- 2025/05/01 00:00 [received] PHST- 2025/08/10 00:00 [accepted] PHST- 2025/12/24 12:54 [medline] PHST- 2025/08/25 20:45 [pubmed] PHST- 2025/08/25 14:22 [entrez] AID - 10.1002/aur.70111 [doi] PST - ppublish SO - Autism Res. 2025 Dec;18(12):2538-2547. doi: 10.1002/aur.70111. Epub 2025 Aug 25. PMID- 40853317 OWN - NLM STAT- MEDLINE DCOM- 20260702 LR - 20260702 IS - 2391-5854 (Electronic) IS - 0033-2674 (Linking) VI - 60 IP - 2 DP - 2026 Apr 30 TI - Muscle Dysmorphic Disorder Inventory (MDDI) - Polish adaptation, women's version. PG - 323-338 LID - 202230 [pii] LID - 10.12740/PP/OnlineFirst/202230 [doi] AB - OBJECTIVES: Muscle dysmorphia is a disorder in which one incorrectly assesses one's body as too thin and insufficiently muscular. Data on dysmorphia in the female population are still limited. The aim of the study was to culturally adapt and validate the Muscle Dysmorphic Disorder Inventory (MDDI) by Hildebrandt et al. (2004) in the female population. METHODS: The study included 204 women aged 18 to 35 years. In addition to the MDDI, the following were used: (1) a personal questionnaire to control secondary variables (e.g. BMI, sexual orientation, self-rated health), (2) the Body Image Questionnaire (BIQ) to check the validity of the validated tool, and (3) a subscale of the KOMPAN questionnaire to operationalise the variable "physical activity". RESULTS: It was noted that there are intergroup differences in the intensity of muscle dysmorphia symptoms in the studied sample between women involved in moderate and high levels of leisure-time physical activity. It was proven that the higher the BMI value and the greater the difference between actual and expected body weight, the greater the intensity of muscle dysmorphia symptoms in the studied women. CONCLUSIONS: The results of the study confirmed the three-factor structure of the MDDI-PL and demonstrated its satisfactory reliability both as a whole and in its separate subscales. MDDI-PL can be used as a screening tool, especially for examining women who engage in physical activity (including competitively). FAU - Ziolkowska, Beata AU - Ziolkowska B AD - Wydzial Psychologii UKW. FAU - Loboda, Dorota AU - Loboda D AD - Wydzial Nauk o Zdrowiu i Kulturze Fizycznej w Bydgoszczy. FAU - Zaczek, Zaneta AU - Zaczek Z AD - Wydzial Psychologii UKW. LA - eng LA - pol PT - Journal Article TT - Muscle Dysmorphic Disorder Inventory (MDDI) - polska adaptacja, wersja dla kobiet. DEP - 20260430 PL - Poland TA - Psychiatr Pol JT - Psychiatria polska JID - 0103314 SB - IM MH - Humans MH - Female MH - Adult MH - *Body Dysmorphic Disorders/diagnosis/psychology MH - Poland MH - Surveys and Questionnaires/standards MH - *Body Image/psychology MH - Young Adult MH - Adolescent MH - Reproducibility of Results MH - Body Satisfaction MH - Psychometrics MH - *Self Concept MH - Women's Health OTO - NOTNLM OT - muscle dysmorphia OT - physical activity OT - women EDAT- 2025/08/25 12:49 MHDA- 2026/07/02 22:34 CRDT- 2025/08/25 10:33 PHST- 2026/07/02 22:34 [medline] PHST- 2025/08/25 12:49 [pubmed] PHST- 2025/08/25 10:33 [entrez] AID - 202230 [pii] AID - 10.12740/PP/OnlineFirst/202230 [doi] PST - ppublish SO - Psychiatr Pol. 2026 Apr 30;60(2):323-338. doi: 10.12740/PP/OnlineFirst/202230. Epub 2026 Apr 30. PMID- 40852651 OWN - NLM STAT- MEDLINE DCOM- 20250825 LR - 20250827 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Assessing the dietary habits and nutritional status of secondary school students in Krakow and the Myslenice district (2016-2017): implications for public health. PG - 1592361 LID - 10.3389/fpubh.2025.1592361 [doi] LID - 1592361 AB - Adolescence is a period of rapid growth and development, making proper nutrition essential for overall health and fitness, as well as proper physical and cognitive development. The aim of this study was to assess consumption patterns of everyday food, fast food, and snacks among adolescents aged 12-16 years, depending on sex and nutritional status. The survey was conducted in the Myslenice district (a second-level local government unit) and in Krakow, Poland, between 2016 and 2017. It included secondary school students aged 12-16. The survey of children after obtaining consent from parents was conducted based on the validated FFQ questionnaire. Anthropometric measurements included body weight, height, body fat percentage, and waist and hip circumference. Depending on the BMI value, the children were divided into three groups-underweight, overweight and obese, and with normal body weight. Significant differences in the frequency of fast food consumption and snacking were observed between boys and girls, depending on BMI. The more frequent consumption of whole meal bread by overweight and obese adolescents, along with their lower intake of foods high in simple sugars and fast food, may suggest conscious attempts to control their diet, reflecting changing eating habits among young people. In contrast, the higher fast food consumption among underweight girls, compared to other groups, may suggest a potential link between low body weight and a tendency to consume foods with low nutritional value. Special attention should be given to snacking habits, as they play a significant role in shaping young people's diet. CI - Copyright (c) 2025 Zwirska, Blaszczyk-Bebenek, Boleslawska, Jagielski, Ostachowska-Gasior and Kawalec. FAU - Zwirska, Jasmina AU - Zwirska J AD - Department of Nutrition and Drug Research, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland. FAU - Blaszczyk-Bebenek, Ewa AU - Blaszczyk-Bebenek E AD - Department of Nutrition and Drug Research, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland. FAU - Boleslawska, Izabela AU - Boleslawska I AD - Department of Bromatology, Poznan University of Medical Sciences, Poznan, Poland. FAU - Jagielski, Pawel AU - Jagielski P AD - Department of Nutrition and Drug Research, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland. FAU - Ostachowska-Gasior, Agnieszka AU - Ostachowska-Gasior A AD - Department of Nutrition and Drug Research, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland. FAU - Kawalec, Pawel AU - Kawalec P AD - Department of Nutrition and Drug Research, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland. LA - eng PT - Journal Article DEP - 20250807 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - Poland/epidemiology MH - *Nutritional Status MH - *Feeding Behavior MH - Child MH - *Students/statistics & numerical data MH - Surveys and Questionnaires MH - *Public Health MH - Body Mass Index MH - Schools MH - Snacks MH - Fast Foods/statistics & numerical data PMC - PMC12367495 OTO - NOTNLM OT - dietary habits OT - fast food products OT - nutrition OT - nutritional status OT - secondary school students OT - snacking COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/08/25 16:44 MHDA- 2025/08/25 16:45 PMCR- 2025/08/07 CRDT- 2025/08/25 05:17 PHST- 2025/03/12 00:00 [received] PHST- 2025/07/21 00:00 [accepted] PHST- 2025/08/25 16:45 [medline] PHST- 2025/08/25 16:44 [pubmed] PHST- 2025/08/25 05:17 [entrez] PHST- 2025/08/07 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1592361 [doi] PST - epublish SO - Front Public Health. 2025 Aug 7;13:1592361. doi: 10.3389/fpubh.2025.1592361. eCollection 2025. PMID- 40852149 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250914 LR - 20250914 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 16 DP - 2025 TI - Smartphone sensor-based depression detection in campus environments: a proof-of-concept study with small-sample behavioral analysis. PG - 1468334 LID - 10.3389/fpsyt.2025.1468334 [doi] LID - 1468334 AB - INTRODUCTION: Depression is a rising global health issue, particularly among adolescents, with university students facing distinct mental health challenges. METHODS: This proof-of-concept study explores smartphone sensor-based depression detection in Chinese university campus settings using a small sample of 12 participants. We utilized data from accelerometers, gyroscopes, and light sensors to establish associations between smartphone-derived behavioral patterns and PHQ-9 scores, a standard depression measure. A customized data processing scheme tailored to campus life enabled the extraction of 18 feature sequences reflecting depressive symptoms. Feature selection was conducted using Pearson correlation, and model validation was performed using leave-one-out cross-validation with common classification algorithms. RESULTS: The results yielded accuracy rates between 73.11% and 88.24%. Findings showed negative correlations between PHQ-9 scores and dietary regularity, bedtime, and physical activity levels. DISCUSSION: This pioneering study highlights smartphone sensors' potential for early depression detection in Chinese higher education, supporting non-invasive mental health interventions. CI - Copyright (c) 2025 Bai, Liu, Zhang and Tolba. FAU - Bai, Yichen AU - Bai Y AD - School of Information Science and Engineering, Lanzhou University, Lanzhou, China. FAU - Liu, Yueze AU - Liu Y AD - School of Information Science and Engineering, Lanzhou University, Lanzhou, China. FAU - Zhang, Yang AU - Zhang Y AD - Cyberspace Administration of Lanzhou University, Lanzhou, China. FAU - Tolba, Amr AU - Tolba A AD - Computer Science Department, Community College, King Saud University, Riyadh, Saudi Arabia. LA - eng PT - Journal Article DEP - 20250807 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC12368363 OTO - NOTNLM OT - daily mobile behavior analysis OT - depression detection OT - feature engineering OT - machine learning OT - small data samples OT - smartphone sensors COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/08/25 08:44 MHDA- 2025/08/25 08:45 PMCR- 2025/08/07 CRDT- 2025/08/25 05:11 PHST- 2024/07/24 00:00 [received] PHST- 2025/07/03 00:00 [accepted] PHST- 2025/08/25 08:45 [medline] PHST- 2025/08/25 08:44 [pubmed] PHST- 2025/08/25 05:11 [entrez] PHST- 2025/08/07 00:00 [pmc-release] AID - 10.3389/fpsyt.2025.1468334 [doi] PST - epublish SO - Front Psychiatry. 2025 Aug 7;16:1468334. doi: 10.3389/fpsyt.2025.1468334. eCollection 2025. PMID- 40851899 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250914 LR - 20250914 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - Composite Index of Anthropometric Failure to assess malnutrition in low- and middle-income countries across Africa, Asia, and Europe: a state-of-the-art review. PG - 1558381 LID - 10.3389/fnut.2025.1558381 [doi] LID - 1558381 AB - BACKGROUND: The Composite Index of Anthropometric Failure (CIAF) provides a comprehensive framework for assessing malnutrition by combining multiple anthropometric measures into one metric. Traditional indicators like stunting, wasting, and underweight are often used in isolation, underestimating the true malnutrition burden. Limited research has explored CIAF's application, particularly in low- and middle-income countries (LMICs) where malnutrition is most prevalent. OBJECTIVES: To critically examine the evolution, methodologies, applications, and implications of CIAF in assessing malnutrition in LMICs. METHODS: A comprehensive search was conducted using PubMed, Scopus, Web of Science, and Google Scholar for studies published between 2019 and 2024. Search terms included "Composite Index of Anthropometric Failure," "malnutrition," and "anthropometric measures in low- and middle-income countries." Inclusion criteria focused on studies applying the CIAF framework in LMICs, excluding studies from high-income countries or those lacking detailed methodology. Extracted data included study objectives, population characteristics, methodologies, CIAF prevalence rates, and comparisons with traditional indicators. A critical appraisal checklist assessed study validity, reliability, and relevance to enhance evidence-based decision-making. RESULTS: Composite Index of Anthropometric Failure offers a holistic measure by capturing multiple forms of anthropometric failure, enabling better identification of children with overlapping nutritional deficits. Studies across LMICs demonstrate CIAF's utility in highlighting regional disparities, informing policies, and guiding interventions. CIAF also reveals correlations between malnutrition and factors like socioeconomic status, maternal education, and healthcare access. Despite its advantages, challenges such as data availability and interpretation persist, necessitating further research. CONCLUSION: Composite Index of Anthropometric Failure effectively captures multiple anthropometric failures, offering a more complete assessment of malnutrition. Its application in LMICs highlights regional disparities and socioeconomic gaps, guiding targeted interventions. However, data limitations and interpretation challenges require further study to enhance its global utility. CI - Copyright (c) 2025 Dassie. FAU - Dassie, Godana Arero AU - Dassie GA AD - Oromia Regional Health Bureau, School of Public Health, Adama Hospital Medical College, Adama, Ethiopia. LA - eng PT - Journal Article PT - Review DEP - 20250807 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12367505 OTO - NOTNLM OT - Composite Index of Anthropometric Failure OT - low- and middle-income countries OT - malnutrition assessment OT - nutritional policy OT - stunting COIS- The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/08/25 16:44 MHDA- 2025/08/25 16:45 PMCR- 2025/08/07 CRDT- 2025/08/25 05:08 PHST- 2025/01/13 00:00 [received] PHST- 2025/06/25 00:00 [accepted] PHST- 2025/08/25 16:45 [medline] PHST- 2025/08/25 16:44 [pubmed] PHST- 2025/08/25 05:08 [entrez] PHST- 2025/08/07 00:00 [pmc-release] AID - 10.3389/fnut.2025.1558381 [doi] PST - epublish SO - Front Nutr. 2025 Aug 7;12:1558381. doi: 10.3389/fnut.2025.1558381. eCollection 2025. PMID- 40849080 OWN - NLM STAT- MEDLINE DCOM- 20251219 LR - 20251222 IS - 2212-2672 (Print) IS - 2212-2672 (Linking) VI - 126 IP - 1 DP - 2026 Jan TI - Evaluation of the Validity of Mi Nino a la Hora de Comer Parent Self-Assessment of Food Parenting Behaviors With Videotaped Mealtime Behaviors. PG - 156194 LID - S2212-2672(25)00565-9 [pii] LID - 10.1016/j.jand.2025.08.005 [doi] AB - BACKGROUND: Mi Nino a la Hora de Comer (Mi Nino) is a visually enhanced, Spanish-language, parent self-assessment tool designed to measure food parenting behaviors of low-income, Spanish-speaking caregivers of preschool-aged children. OBJECTIVE: The aim of this study was to evaluate the construct and convergent validity of Mi Nino. DESIGN: Videotaped mealtime behaviors at home were used to test for Mi Nino construct validity. Concurrent caregiver reports of general parenting styles and children's body mass index were used to test for convergent validity with Mi Nino scores. PARTICIPANTS/SETTING: Data were drawn from the Ninos Sanos study collected between 2016-2017. Participants (N = 273) were recruited through Head Start and Special Supplemental Nutrition Program for Women, Infants, and Children centers in the Sacramento, CA, metropolitan area and were eligible if they were at least 18 years old, the primary caregiver of a child between ages 3 and 5 years, declared Spanish as their preferred language, and were enrolled in Head Start or the Special Supplemental Nutrition Program for Women, Infants, and Children. Participants who completed Mi Nino, general parenting style surveys, and child anthropometric measurements (n = 199) were included in the current analysis. A subset of participants self-selected to complete a videotaped mealtime in their homes (n = 60). Video corruption occurred with 1 video, resulting in N = 59 final videotape sample. MAIN OUTCOME MEASURES: Parent-centered and child-centered parent mealtime behaviors obtained via observed mealtimes, child body mass index z scores, and self-reports of general parenting styles were used to assess the validity of Mi Nino scores. STATISTICAL ANALYSES PERFORMED: Two-way analysis of variance was used to assess differences in Mi Nino scores by observed mealtime behaviors, and linear regression was used to test associations between Mi Nino scores and child body mass index z scores and general parenting styles. RESULTS: Parent-centered Mi Nino scores were positively associated with the rate of observed parent-centered behaviors (F = 2.49; P < .05) and negatively with child body mass index z scores (r = -0.19; P < .01). Parent-centered Mi Nino scores were positively associated with parent self-assessments of authoritarian general parenting styles (r = 0.35; P < .01), and child-centered Mi Nino scores were positively associated with parent self-assessments of authoritative general parenting styles (r = 0.44; P < .01). CONCLUSIONS: Results provide partial support for construct and convergent validity of the Mi Nino self-assessment tool to assess food parenting behaviors with Spanish-speaking caregivers of young children who have low incomes. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Ontai, Lenna L AU - Ontai LL AD - Department of Human Ecology, University of California, Davis, California. Electronic address: lontai@ucdavis.edu. FAU - Diaz Rios, L Karina AU - Diaz Rios LK AD - Division of Agriculture and Natural Resources, University of California, Merced, California. FAU - Shilts, Mical K AU - Shilts MK AD - Department of Nutrition, Food, and Dietetics, California State University, Sacramento, California. FAU - Lanoue, Louise AU - Lanoue L AD - Analytics and Phenotyping Mouse Biology Program, University of California, Davis, California. FAU - Townsend, Marilyn S AU - Townsend MS AD - Department of Nutrition, University of California, Davis, California. LA - eng PT - Journal Article PT - Validation Study DEP - 20250821 PL - United States TA - J Acad Nutr Diet JT - Journal of the Academy of Nutrition and Dietetics JID - 101573920 SB - IM MH - Adult MH - Child, Preschool MH - Female MH - Humans MH - Male MH - Body Mass Index MH - *Feeding Behavior/psychology MH - Hispanic or Latino/psychology MH - *Meals/psychology MH - *Parenting/psychology MH - *Parents/psychology MH - Poverty MH - Reproducibility of Results MH - *Self-Assessment MH - Surveys and Questionnaires/standards MH - *Videotape Recording OTO - NOTNLM OT - Feeding practices OT - Mealtime behaviors OT - Observation OT - Parenting OT - Spanish-speaking EDAT- 2025/08/24 00:46 MHDA- 2025/12/20 00:41 CRDT- 2025/08/23 19:27 PHST- 2024/02/21 00:00 [received] PHST- 2025/04/27 00:00 [revised] PHST- 2025/08/14 00:00 [accepted] PHST- 2025/12/20 00:41 [medline] PHST- 2025/08/24 00:46 [pubmed] PHST- 2025/08/23 19:27 [entrez] AID - S2212-2672(25)00565-9 [pii] AID - 10.1016/j.jand.2025.08.005 [doi] PST - ppublish SO - J Acad Nutr Diet. 2026 Jan;126(1):156194. doi: 10.1016/j.jand.2025.08.005. Epub 2025 Aug 21. PMID- 40841634 OWN - NLM STAT- MEDLINE DCOM- 20250821 LR - 20250825 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Aug 21 TI - Health-Related quality of life and the impact of traditional, complementary and integrative Medicine - an Online - Representative Cross-Sectional survey in Germany. PG - 2870 LID - 10.1186/s12889-025-23908-5 [doi] LID - 2870 AB - BACKGROUND: Traditional, Complementary, and Integrative Medicine (TCIM) is widely used in Germany. Approximately 70% of the German population report lifetime use, with 32% indicating usage within the past year and 18% currently. This study examines the association between TCIM utilization and health-related factors, including sociodemographic characteristics and health-related quality of life (HRQoL) in Germany. METHODS: An online survey of 4,065 German adults (aged 18-75) was conducted in 2022. HRQoL was assessed with globally recognized and extensively validated instruments using the EQ-5D-5 L descriptive system and index values. We compared HRQoL based on age, gender, income, TCIM use and attitudes, medical conditions, dietary patterns, and social milieus (Sinus-Milieus((R))). The EQ-5D-5 L index ranges from 1 (perfect health) to 0.05; effect size [ES] = 0.0-0.13), and 20-meter sprint ( p = 0.07, ES = 0.69). However, CMJ performance exhibited significant increases in reactive strength index-modified, peak and mean propulsive force, peak and mean braking force, and braking net impulse ( p < 0.001-0.017; ES = 0.50-0.73), alongside reductions in propulsive phase duration and time to take off ( p < 0.001; ES = 0.49 and 0.019; ES = 0.88, respectively). Despite 14 days of detraining, IMTP and sprint performance remained stable, while some braking and propulsive metrics of CMJ demonstrated significant positive adaptations. Overall, these findings suggest that short-term detraining does not impair maximal force production or sprint ability and induces alterations in jump mechanics, particularly within braking and propulsive phases of CMJ. Coaches should consider the observed neuromuscular changes-particularly the reduction in take-off time despite stable jump height-when planning training resumption strategies. Emphasizing the restoration of explosive strength and reactivation of movement patterns early in the return-to-training phase may help mitigate potential performance fluctuations after short-term detraining. CI - Copyright (c) 2025 National Strength and Conditioning Association. FAU - Nieto-Acevedo, Raul AU - Nieto-Acevedo R AD - Faculty of Sports Sciences, Universidad Alfonso X el Sabio, Villanueva de la Canada, Spain. FAU - Garcia-Sanchez, Carlos AU - Garcia-Sanchez C AUID- ORCID: 0000-0002-7112-3636 AD - Department of Sports, Faculty of Physical Activity and Sport Science (INEF), Universidad Politecnica de Madrid, Madrid, Spain. FAU - Romero-Moraleda, Blanca AU - Romero-Moraleda B AD - Department of Physical Education, Sport and Human Movement, Autonomous University of Madrid, Madrid, Spain. AD - Applied Biomechanics and Sports Technology Research Group, Autonomous University of Madrid, Madrid, Spain. FAU - Varela, Daniel AU - Varela D AD - Department of Physical Education, Sport and Human Movement, Autonomous University of Madrid, Madrid, Spain. AD - Applied Biomechanics and Sports Technology Research Group, Autonomous University of Madrid, Madrid, Spain. FAU - Cabarkapa, Dimitrije AU - Cabarkapa D AD - Jayhawk Athletic Performance Laboratory, Wu Tsai Human Performance Alliance, Department of Health, Sport and Exercise Sciences, University of Kansas, Lawrence, Kansas; and. AD - D2 Laboratory, Novi Sad, Serbia. LA - eng PT - Journal Article DEP - 20250813 PL - United States TA - J Strength Cond Res JT - Journal of strength and conditioning research JID - 9415084 SB - IM MH - Humans MH - Male MH - *Basketball/physiology MH - *Athletic Performance/physiology MH - Adolescent MH - *Muscle Strength/physiology MH - Longitudinal Studies MH - *Physical Conditioning, Human/methods MH - *Muscle, Skeletal/physiology MH - Exercise Test MH - Athletes OTO - NOTNLM OT - countermovement jump OT - force plates OT - isometric mid-thigh pull OT - monitoring OT - strength OT - tapering EDAT- 2025/08/22 20:47 MHDA- 2025/10/21 18:30 CRDT- 2025/08/22 16:02 PHST- 2025/10/21 18:30 [medline] PHST- 2025/08/22 20:47 [pubmed] PHST- 2025/08/22 16:02 [entrez] AID - 00124278-990000000-00785 [pii] AID - 10.1519/JSC.0000000000005208 [doi] PST - ppublish SO - J Strength Cond Res. 2025 Nov 1;39(11):e1305-e1312. doi: 10.1519/JSC.0000000000005208. Epub 2025 Aug 13. PMID- 40845162 OWN - NLM STAT- MEDLINE DCOM- 20251118 LR - 20260306 IS - 1365-2133 (Electronic) IS - 0007-0963 (Linking) VI - 193 IP - 6 DP - 2025 Nov 18 TI - Quality of life, psychosocial difficulties and bullying in paediatric patients with alopecia areata: a European cross-sectional study. PG - 1165-1173 LID - 10.1093/bjd/ljaf318 [doi] AB - BACKGROUND: Alopecia areata (AA) is a chronic immune-mediated condition leading to nonscarring hair loss. Its visible nature often leads to stigmatization and bullying, which can negatively affect the mental health and quality of life (QoL) of adolescents. OBJECTIVES: To investigate the experiences of bullying, psychosocial challenges and QoL in adolescents with AA. METHODS: This cross-sectional study included 417 participants aged between 10 and 17 years, with 156 adolescents diagnosed with AA from 6 European countries and 261 healthy German controls. Data collection involved validated questionnaires. These included the Revised Olweus Bully/Victim Questionnaire for bullying, the Strengths and Difficulties Questionnaire for psychosocial difficulties, and the Pediatric Quality of Life Inventory for QoL. Clinical data, including AA severity score, were also recorded. Statistical analyses employed parametric and nonparametric methods, including multivariate analysis of variance, Mann-Whitney U-tests, t-tests and correlation analyses. RESULTS: Adolescents with AA reported significantly higher rates of general and verbal bullying, with hair loss and nail damage commonly identified as reasons for bullying. Girls experienced more emotional distress and bullying, while boys reported better emotional and social QoL. Physical functioning (i.e. limitations in physical activity, pain or low energy) was significantly lower in the AA group, although overall QoL differences were low. Longer disease duration was associated with greater emotional difficulties and reduced school functioning. No association was found with the age of the participant or the severity of the disease. CONCLUSIONS: Adolescents with AA often face significant challenges, including higher rates of bullying and emotional struggles compared with healthy controls. Developing targeted interventions to combat stigma and support mental and emotional wellbeing of paediatric patients with AA, in addition to a collaborative effort involving dermatologists, psychologists and educators could possibly make a meaningful difference in improving the QoL for these young individuals. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of British Association of Dermatologists. FAU - Franz, Agathe AU - Franz A AUID- ORCID: 0009-0002-3427-9583 AD - Charite - Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Department of Dermatology, Venereology and Allergology, Clinical Research Center for Hair and Skin Science, Berlin, Germany. FAU - Constantinou, Andria AU - Constantinou A AUID- ORCID: 0000-0002-6569-8636 AD - Charite - Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Department of Dermatology, Venereology and Allergology, Clinical Research Center for Hair and Skin Science, Berlin, Germany. FAU - Hillmann, Kathrin AU - Hillmann K AUID- ORCID: 0000-0001-7251-5351 AD - Charite - Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Department of Dermatology, Venereology and Allergology, Clinical Research Center for Hair and Skin Science, Berlin, Germany. FAU - Chasapi, Vasiliki AU - Chasapi V AUID- ORCID: 0000-0003-2168-3317 AD - Department of Dermatology and Venereology of NHS, Hospital of Skin and Venereal Diseases, Andreas Syggros, Athens, Greece. FAU - Vano Galvan, Sergio AU - Vano Galvan S AUID- ORCID: 0000-0003-2773-7494 AD - Trichology Unit, Ramon y Cajal University Hospital and Trichology and Hair Transplant Unit, Pedro Jaen Group Clinic, University of Alcala, Madrid, Spain. FAU - Leducq, Sophie AU - Leducq S AUID- ORCID: 0000-0002-4860-6365 AD - Unit of Pediatric Dermatology, Department of Dermatology, University Hospital of Tours, Tours, France. AD - INSERM, SPHERE, U1246, Tours University, Nantes University, Tours, France. FAU - Maruani, Annabel AU - Maruani A AUID- ORCID: 0000-0003-3734-810X AD - Unit of Pediatric Dermatology, Department of Dermatology, University Hospital of Tours, Tours, France. AD - INSERM, SPHERE, U1246, Tours University, Nantes University, Tours, France. FAU - Abasq, Claire AU - Abasq C AUID- ORCID: 0000-0002-1301-3463 AD - Department of Dermatology, Brest University Hospital, Brest, France. FAU - Piraccini, Bianca Maria AU - Piraccini BM AUID- ORCID: 0000-0001-6537-9689 AD - Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. AD - Department of Medical and Surgical Sciences, Alma Mater Studiorum - University of Bologna, Bologna, Italy. FAU - Rudnicka, Lidia AU - Rudnicka L AUID- ORCID: 0000-0002-8308-1023 AD - Department of Dermatology, Medical University of Warsaw, Warsaw, Poland. FAU - Prat Torres, Carolina AU - Prat Torres C AD - Department of Dermatology, Hospital Sant Joan de Deu de Barcelona, Esplugues de Llobregat, Barcelona, Spain. FAU - Starace, Michela AU - Starace M AUID- ORCID: 0000-0002-3981-1527 AD - Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. AD - Department of Medical and Surgical Sciences, Alma Mater Studiorum - University of Bologna, Bologna, Italy. FAU - Waskiel-Burnat, Anna AU - Waskiel-Burnat A AD - Department of Dermatology, Medical University of Warsaw, Warsaw, Poland. FAU - Pfetsch, Jan AU - Pfetsch J AUID- ORCID: 0000-0001-7998-1291 AD - Technische Universitat Berlin, Department of Educational Psychology, Berlin, Germany. AD - Masaryk University, Interdisciplinary Research Team on Internet and Society, Brno, Czech Republic. FAU - Blume-Peytavi, Ulrike AU - Blume-Peytavi U AUID- ORCID: 0000-0003-3528-3752 AD - Charite - Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Department of Dermatology, Venereology and Allergology, Clinical Research Center for Hair and Skin Science, Berlin, Germany. LA - eng PT - Journal Article PT - Multicenter Study PL - England TA - Br J Dermatol JT - The British journal of dermatology JID - 0004041 SB - IM CIN - Br J Dermatol. 2025 Nov 18;193(6):1042-1043. doi: 10.1093/bjd/ljaf372. PMID: 40971897 MH - Humans MH - *Quality of Life/psychology MH - Female MH - Adolescent MH - Male MH - Cross-Sectional Studies MH - *Alopecia Areata/psychology MH - Child MH - *Bullying/psychology/statistics & numerical data MH - Europe/epidemiology MH - Case-Control Studies MH - Surveys and Questionnaires MH - Sex Factors OAB - Alopecia areata (AA) is a disease characterized by hair loss. It affects people of all ages worldwide. AA occurs when the immune system attacks hair follicles. It can range from small patches to total hair loss on the scalp, the face and the entire body. The visible nature of AA has been found to have a significant impact on young people's psychological wellbeing. In some cases, AA has been associated with bullying by peers. In this study, we looked at how adolescents with AA experience bullying, mental health challenges and changes in their quality of life (QoL). We carried out this research across several European countries. These included France, Germany, Greece, Italy, Poland and Spain. Our study involved 156 adolescents who had AA, and we compared them with 261 adolescents without AA. We used surveys to measure levels of bullying, mental health and QoL. Details about each participant's medical condition (e.g. AA severity) were also collected. We found that adolescents with AA experienced much higher rates of bullying compared with those without AA. Girls with AA appeared to face more emotional struggles and bullying than boys with AA. Boys reported better emotional and social wellbeing. We also found that AA affected physical functioning of adolescents with AA more strongly compared with the control group. Longer-lasting AA was associated with greater emotional challenges and difficulties in school. Our study results highlight the importance of emotional support for adolescents with AA. Teamwork between dermatologists, psychologists and teachers offers a promising way forward. Their efforts could improve the QoL and wellbeing of adolescents with AA. OABL- eng COIS- Conflicts of interest: U.B.-P. was speaker and/or consultant and/or investigator and/or has received research funding from AbbVie, Adaran, Almirall, Bayer, Amryt, Boots Healthcare, Cantabria Labs, Cassiopeia, CeraVe, Dermocosmetique Vichy, Eli Lilly, FomF, Galderma Laboratorium GmbH, GSK, Infectopharm, Johnson & Johnson, Laboratoires Bailleuil, Legacy, Leo Pharma, Novartis, Pfizer, Pierre Fabre, Sanofi Regeneron and Sun Pharmaceutical. K.H. was speaker for FomF and Investigator for AbbVie, Bayer, Amryt, Cantabria Labs, Cassiopeia, Eli Lilly, Infectopharm, Legacy, LEO Pharma, Sanofi Regeneron and Sun Pharmaceutical. B.M.P. was speaker, consultant or investigator for and has received research funding from Almirall, Difa Cooper, Dercos-L'Oreal, Eli Lilly, ISDIN, Legacy Healthcare, Pierre Fabre-Ducray, Giuliani and Olistic Pfizer. EDAT- 2025/08/22 20:44 MHDA- 2025/11/18 18:31 CRDT- 2025/08/22 14:15 PHST- 2025/06/03 00:00 [received] PHST- 2025/07/28 00:00 [revised] PHST- 2025/08/09 00:00 [accepted] PHST- 2025/11/18 18:31 [medline] PHST- 2025/08/22 20:44 [pubmed] PHST- 2025/08/22 14:15 [entrez] AID - 8239963 [pii] AID - 10.1093/bjd/ljaf318 [doi] PST - ppublish SO - Br J Dermatol. 2025 Nov 18;193(6):1165-1173. doi: 10.1093/bjd/ljaf318. PMID- 40844100 OWN - NLM STAT- MEDLINE DCOM- 20250825 LR - 20260502 IS - 0971-5916 (Print) IS - 0971-5916 (Linking) VI - 161 IP - 5 DP - 2025 May TI - Awareness about the symptoms & risk factors of ovarian cancer among women in North Urban Bengaluru: A cross-sectional study. PG - 502-509 LID - 10.25259/IJMR_1351_2024 [pii] AB - Background & objectives In low or medium Human Development Index (HDI) nations, late-stage ovarian cancer diagnosis in 75 per cent of women is known to hinder treatment outcomes. However, knowledge and awareness can significantly impact disease progression and outcomes. This study was conducted to determine ovarian cancer awareness, risk factors, and symptoms among women in a community-based setting. Methods This study was conducted in Yelahanka, North Urban Bengaluru, between October 2023 and July 2024. A validated questionnaire, Ovarian Cancer Awareness Measure (OCAM), was used to interview the women. Household data were collected through systematic sampling using the Epicollect-5 mobile application and analysed with Jamovi software version 2.3.28. Results A total of 375 women were interviewed during the study, of which 28.5 per cent were aware of ovarian cancer. With median scores of 4 out of 10 for symptoms and 5 out of 12 for risk factors, there was a general lack of awareness of symptoms and risk factors. Commonly identified symptoms included extreme fatigue (61.7%), pelvic pain (54.2%), abdominal enlargement (51.4%), and back pain (43.9%). The socioeconomic class was significantly associated with symptom awareness (P<0.05). On identifying risk factors of ovarian cancer, the most recognised were a history of ovarian cysts (71%), smoking (64.48%), age >50 yr (55.54%), and being overweight (47.6%). Age, marital status, education, and socioeconomic class (P<0.05) influenced awareness of risk factors. Interpretation & conclusions This study found low ovarian cancer awareness among women in North Urban Bengaluru, emphasising the necessity for focused awareness programmes to enhance early diagnosis and improve health outcomes. FAU - Raghavendra, Surabhi Sai P AU - Raghavendra SSP AD - Department of Public Health, Nitte Institute of Allied Health Sciences (NIAHS), Nitte (Deemed to be University), Mangaluru, India. FAU - Dmello, Mackwin Kenwood AU - Dmello MK AD - Department of Public Health, Nitte Institute of Allied Health Sciences (NIAHS), Nitte (Deemed to be University), Mangaluru, India. FAU - Alex, Anjusha AU - Alex A AD - Department of Biostatistics, KS Hegde Medical Academy, Nitte (Deemed to be University), Mangaluru, India. FAU - Nandimath, Priya AU - Nandimath P AD - Department of Public Health, Padmashree School of Public Health, Bengaluru, Karnataka, India. LA - eng PT - Journal Article PL - United States TA - Indian J Med Res JT - The Indian journal of medical research JID - 0374701 SB - IM MH - Risk Factors MH - *Health Knowledge, Attitudes, Practice MH - *Ovarian Neoplasms/diagnosis/epidemiology MH - Cross-Sectional Studies MH - India/epidemiology MH - Surveys and Questionnaires/statistics & numerical data MH - Interviews as Topic MH - Urban Population/statistics & numerical data MH - Humans MH - Female MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged MH - Aged PMC - PMC12550386 OTO - NOTNLM OT - Awareness OT - gynaecological cancers OT - knowledge OT - ovarian cancer OT - risk factors OT - symptoms COIS- None. EDAT- 2025/08/22 12:45 MHDA- 2025/08/22 12:46 PMCR- 2025/05/01 CRDT- 2025/08/22 07:58 PHST- 2024/09/08 00:00 [received] PHST- 2025/04/15 00:00 [accepted] PHST- 2025/08/22 12:46 [medline] PHST- 2025/08/22 12:45 [pubmed] PHST- 2025/08/22 07:58 [entrez] PHST- 2025/05/01 00:00 [pmc-release] AID - 10.25259/IJMR_1351_2024 [pii] AID - 10.25259/IJMR_1351_2024 [doi] PST - ppublish SO - Indian J Med Res. 2025 May;161(5):502-509. doi: 10.25259/IJMR_1351_2024. PMID- 40843966 OWN - NLM STAT- MEDLINE DCOM- 20251016 LR - 20251016 IS - 1475-2662 (Electronic) IS - 0007-1145 (Linking) VI - 134 IP - 4 DP - 2025 Aug 28 TI - Turkish adaptation of the Eating-Related Eco-Concern questionnaire: validity and reliability study. PG - 333-342 LID - 10.1017/S0007114525104200 [doi] AB - The study aimed to translate the Eating-Related Eco-Concern (EREC) questionnaire into Turkish, adapt it cross-culturally, and evaluate its psychometric properties. EREC is a ten-item scale measuring how adults consider ecological impact in food choices due to climate change concerns. The study was conducted in Mersin between November 2023 and February 2024 with 442 adults (18-65 years) through face-to-face interviews. The Turkish version was adapted using the Translation-Back Translation method, and language validity was ensured. Face validity was evaluated through a pilot study with forty participants. Construct validity was initially assessed using exploratory factor analysis (EFA) with data from 200 participants, followed by confirmatory factor analysis (CFA) conducted on an independent sample of 242 participants to verify the factor structure. The reliability of the scale was assessed by test-retest analysis with 106 participants from the main sample (n 442), and consistency was measured by the intraclass correlation coefficient (ICC). The factor structure and model fit were evaluated using indices such as Comparative Fit Index (CFI), Goodness-of-Fit Index (GFI) and root mean square error of approximation (RMSEA). 68.3 % of the participants were female, whereas 31.7 % were male. The group's median BMI value was 24.3 (21.6-27.1), with 52.9 % classified as 'normal' according to the BMI classification. Factor 2 had a low score, but it was found to be adequate for other factors and the total scale score. The Turkish adaptation of the EREC questionnaire has been found to be a valid and reliable scale, as confirmed by comprehensive evaluations. FAU - Saban Bozan, Gaye AU - Saban Bozan G AUID- ORCID: 0009-0005-4586-6427 AD - Nuh Naci Yazgan University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Kayseri, Turkey. FAU - Capar, Asli Gizem AU - Capar AG AUID- ORCID: 0000-0001-5459-9424 AD - Nuh Naci Yazgan University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Kayseri, Turkey. LA - eng PT - Journal Article PT - Validation Study DEP - 20250822 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM MH - Humans MH - Adult MH - Male MH - Female MH - Middle Aged MH - Reproducibility of Results MH - Turkey MH - Surveys and Questionnaires/standards MH - Young Adult MH - Adolescent MH - Aged MH - Psychometrics MH - *Climate Change MH - Factor Analysis, Statistical MH - Translations MH - Pilot Projects MH - *Feeding Behavior/psychology OTO - NOTNLM OT - Eco-concern OT - Reliability OT - Scale OT - Sustainable nutrition OT - Validity EDAT- 2025/08/22 12:45 MHDA- 2025/10/16 12:31 CRDT- 2025/08/22 07:14 PHST- 2025/10/16 12:31 [medline] PHST- 2025/08/22 12:45 [pubmed] PHST- 2025/08/22 07:14 [entrez] AID - S0007114525104200 [pii] AID - 10.1017/S0007114525104200 [doi] PST - ppublish SO - Br J Nutr. 2025 Aug 28;134(4):333-342. doi: 10.1017/S0007114525104200. Epub 2025 Aug 22. PMID- 40843074 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250914 LR - 20250914 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 13 DP - 2025 TI - Development and validation of a non-invasive prediction model for identifying high-risk children with metabolic dysfunction-associated fatty liver disease. PG - 1625864 LID - 10.3389/fped.2025.1625864 [doi] LID - 1625864 AB - OBJECTIVE: This study aims to investigate the prevalence and risk factors of Metabolic dysfunction-associated fatty liver disease (MAFLD) in pediatric populations and establish a novel health index scoring system derived from key risk parameters for early identification of high-risk children with MAFLD. METHOD: In this cross-sectional study, a systematic random sampling method was employed to recruit children (6-18 years) with MAFLD. Data collection involved standardized questionnaires and comprehensive anthropometric measurements. The prevalence of MAFLD was determined through epidemiological analysis. Both univariate and multivariate logistic regression models were systematically applied to identify independent risk factors (P < 0.05), with subsequent development of a health index scoring system. The optimal diagnostic threshold for the health index was established using receiver operating characteristic (ROC) curve analysis. RESULTS: The study cohort comprised 2,190 pediatric participants, revealing an overall MAFLD prevalence of 26.30%. Significant demographic disparities were observed: males exhibited a higher prevalence than females. The age, BMI (Body Mass Index), Waist-Hip Ratio (WHR), and Waist-Height Ratio (WHtR) values of the MAFLD group were higher than those of the Non-MAFLD group, and the difference was statistically significant. Multivariable logistic regression subsequently identified seven independent predictors (P < 0.05), age (OR = 1.62, 95% CI 1.36, 1.92), gender (OR = 0.42, 95% CI 0.31,0.57), BMI (OR = 2.15, 95% CI 1.75, 2.64), WHR (OR = 2.10, 95% CI 1.64, 2.69), WHtR (OR = 4.01, 95% CI 3.07, 5.23), sleep duration (OR = 0.71, 95% CI 0.59, 0.85) and dessert consumption (OR = 1.46, 95% CI 1.17, 1.81). Health index demonstrated moderate predictive accuracy in both training (AUC = 0.72, 95% CI 0.68, 0.76) and validation cohorts (AUC = 0.74, 95% CI 0.70, 0.78) with optimal diagnostic threshold at 11.5 points. Calibration analysis revealed satisfactory model fit (Hosmer-Lemeshow chi (2) = 7.32, P = 0.12). Strong concordance was observed between dimension weights and regression coefficients (Pearson's r = 0.93, P < 0.001). CONCLUSION: This study establishes seven independent determinants of MAFLD in pediatric populations: age, gender, BMI, waist-hip ratio, waist-height ratio, sleep duration, and frequent dessert consumption (P < 0.05). The health index demonstrates robust clinical utility for early detection, providing an evidence-based screening protocol for school health programs. Implementation of this quantitative tool could significantly enhance targeted prevention strategies and optimize resource allocation in childhood metabolic disorder surveillance in communities. CI - (c) 2025 Xiaowu, Jian, Yizhu, Ting, Jin, Juan, Sirui, Jinli, Yuchen, Huan, Yuhang and Jun. FAU - Xiaowu, Yuan AU - Xiaowu Y AD - Department of Ultrasound, The First Affiliated Hospital, Shihezi University, Shihezi, China. FAU - Jian, Dong AU - Jian D AD - Department of Ultrasound, The First Affiliated Hospital, Shihezi University, Shihezi, China. FAU - Yizhu, Wen AU - Yizhu W AD - Department of Ultrasound, The First Affiliated Hospital, Shihezi University, Shihezi, China. FAU - Ting, Ma AU - Ting M AD - Department of Ultrasound, The First Affiliated Hospital, Shihezi University, Shihezi, China. FAU - Jin, Tong AU - Jin T AD - Department of Ultrasound, The First Affiliated Hospital, Shihezi University, Shihezi, China. FAU - Juan, Wei AU - Juan W AD - Department of Ultrasound, The First Affiliated Hospital, Shihezi University, Shihezi, China. FAU - Sirui, Wang AU - Sirui W AD - Department of Ultrasound, The First Affiliated Hospital, Shihezi University, Shihezi, China. FAU - Jinli, Wang AU - Jinli W AD - Department of Ultrasound, The First Affiliated Hospital, Shihezi University, Shihezi, China. FAU - Yuchen, He AU - Yuchen H AD - Department of Ultrasound, The First Affiliated Hospital, Shihezi University, Shihezi, China. FAU - Huan, Zhao AU - Huan Z AD - Department of Ultrasound, The First Affiliated Hospital, Shihezi University, Shihezi, China. FAU - Yuhang, Cheng AU - Yuhang C AD - Department of Ultrasound, The First Affiliated Hospital, Shihezi University, Shihezi, China. FAU - Jun, Li AU - Jun L AD - Department of Ultrasound, The First Affiliated Hospital, Shihezi University, Shihezi, China. LA - eng PT - Journal Article DEP - 20250806 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC12364932 OTO - NOTNLM OT - health index OT - metabolic dysfunction-associated fatty liver disease OT - non-alcoholic fatty liver disease OT - pediatric population OT - risk stratification COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/08/22 16:44 MHDA- 2025/08/22 16:45 PMCR- 2025/08/06 CRDT- 2025/08/22 04:42 PHST- 2025/05/17 00:00 [received] PHST- 2025/07/22 00:00 [accepted] PHST- 2025/08/22 16:45 [medline] PHST- 2025/08/22 16:44 [pubmed] PHST- 2025/08/22 04:42 [entrez] PHST- 2025/08/06 00:00 [pmc-release] AID - 10.3389/fped.2025.1625864 [doi] PST - epublish SO - Front Pediatr. 2025 Aug 6;13:1625864. doi: 10.3389/fped.2025.1625864. eCollection 2025. PMID- 40842184 OWN - NLM STAT- MEDLINE DCOM- 20251202 LR - 20260925 IS - 1600-0528 (Electronic) IS - 0301-5661 (Print) IS - 0301-5661 (Linking) VI - 53 IP - 6 DP - 2025 Dec TI - Assessing Total Fluoride Intake in Children: Reliability of Commonly Used Methods. PG - 667-675 LID - 10.1111/cdoe.70015 [doi] AB - OBJECTIVES: Fluoride exposure in children is commonly estimated using questionnaires or urinary biomarkers. However, no study has yet compared these methods for classifying participants into five intake categories ranging from low to high. This study aimed to estimate the extent of agreement and classification consistency between questionnaire- and urinary-based methods for assessing total daily fluoride intake (TDFI) in children aged 4-7 years. METHODS: A total of 104 healthy children across three countries (UK, Brazil, Chile) receiving one of three fluoridation modalities (non-fluoridated-water, fluoridated-water, or fluoridated-milk) provided a 24-h urine sample and completed validated dietary and oral hygiene questionnaires. TDFI was estimated from dietary sources and toothpaste ingestion, adjusted for body weight. Urinary fluoride concentration was measured and 24 h-UFE determined by multiplying urine volume by fluoride concentration. TDFI was predicted from 24 h-UFE using the WHO's recommended method. Method agreement was assessed using paired t-tests and Bland-Altman analysis to evaluate continuous fluoride intake estimates. Cohen's kappa was used to assess agreement between categorical intake classifications, while descriptive statistics reported the percentage of children in each intake group. RESULTS: The questionnaire method estimated a higher mean TDFI (0.072 mg/kgbw/day) than the urine-based method (0.058 mg/kgbw/day, p = 0.01). Bland-Altman analysis showed good agreement for lower mean TDFI values (< 0.10 mg/kgbw/day) but increasing variability at higher fluoride intake levels. The questionnaire classified a larger proportion of children as high exposure (>/= 0.1 mg/kgbw/day) than the urine method (19.2% vs. 11.5%), with the greatest discrepancy observed in the fluoridated milk group (46.2% vs. 7.7%). Despite these classifications, Cohen's kappa revealed minimal agreement between methods (kappa = 0.034, p = 0.508), suggesting that classification concordance was likely due to chance. CONCLUSION: This first study comparing questionnaire and urinary methods for assessing TDFI in children found significant discrepancies and minimal agreement, especially in higher exposure groups, highlighting the risk of misclassification and the need for research into combined assessment approaches. CI - (c) 2025 The Author(s). Community Dentistry and Oral Epidemiology published by John Wiley & Sons Ltd. FAU - Zohoori, Fatemeh Vida AU - Zohoori FV AD - School of Health and Life Sciences, Teesside University, Middlesbrough, UK. FAU - Buzalaf, Marilia Afonso Rabelo AU - Buzalaf MAR AD - Bauru School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil. FAU - Maguire, Anne AU - Maguire A AD - School of Dental Sciences, Faculty of Medical Sciences, Newcastle University, Newcastle, UK. FAU - Sanderson, Roy AU - Sanderson R AUID- ORCID: 0000-0002-9580-4751 AD - School of Natural & Environmental Sciences, Newcastle University, Newcastle, UK. FAU - Giacaman, Rodrigo A AU - Giacaman RA AUID- ORCID: 0000-0003-3362-5173 AD - Cariology Unit, Department of Oral Rehabilitation, Faculty of Dentistry, University of Talca, Talca, Chile. FAU - Martignon, Stefania AU - Martignon S AUID- ORCID: 0000-0002-6505-8356 AD - UNICA - Caries Research Unit, Research Department, Universidad El Bosque, Bogota, Colombia. FAU - Beltran, Edgar O AU - Beltran EO AD - UNICA - Caries Research Unit, Research Department, Universidad El Bosque, Bogota, Colombia. FAU - Eskandari, Fatemeh AU - Eskandari F AD - School of Health and Life Sciences, Teesside University, Middlesbrough, UK. FAU - Kronic, Jelena AU - Kronic J AD - School of Health and Life Sciences, Teesside University, Middlesbrough, UK. FAU - Gambetta-Tessini, Karla AU - Gambetta-Tessini K AD - Cariology Unit, Department of Oral Rehabilitation, Faculty of Dentistry, University of Talca, Talca, Chile. AD - National Dental Research Institute, National Dental Centre Singapore, Singapore. FAU - Levy, Flavia Mauad AU - Levy FM AD - Bauru School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil. LA - eng GR - The Borrow Foundation/ PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250821 PL - Denmark TA - Community Dent Oral Epidemiol JT - Community dentistry and oral epidemiology JID - 0410263 RN - Q80VPU408O (Fluorides) RN - 0 (Biomarkers) SB - IM MH - Healthy Volunteers MH - Humans MH - Male MH - Female MH - Child, Preschool MH - Child MH - Reproducibility of Results MH - *Fluorides/administration & dosage/analysis MH - Biomarkers/urine MH - *Urinalysis/classification/methods/statistics & numerical data MH - United Kingdom/epidemiology MH - Brazil/epidemiology MH - Chile/epidemiology MH - Fluoridation/methods MH - *Diet Surveys/classification/methods/statistics & numerical data MH - Eating MH - *Dietary Exposure/analysis/classification/statistics & numerical data PMC - PMC12627261 COIS- The authors declare no conflicts of interest. EDAT- 2025/08/22 08:45 MHDA- 2025/11/19 06:32 PMCR- 2025/11/19 CRDT- 2025/08/22 02:03 PHST- 2025/07/09 00:00 [revised] PHST- 2025/03/25 00:00 [received] PHST- 2025/07/26 00:00 [accepted] PHST- 2025/11/19 06:32 [medline] PHST- 2025/08/22 08:45 [pubmed] PHST- 2025/08/22 02:03 [entrez] PHST- 2025/11/19 00:00 [pmc-release] AID - CDOE70015 [pii] AID - 10.1111/cdoe.70015 [doi] PST - ppublish SO - Community Dent Oral Epidemiol. 2025 Dec;53(6):667-675. doi: 10.1111/cdoe.70015. Epub 2025 Aug 21. PMID- 40836281 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260812 IS - 1471-2342 (Electronic) IS - 1471-2342 (Linking) VI - 25 IP - 1 DP - 2025 Aug 20 TI - Consistency and reliability of ultrasound-derived fat fraction in hepatic steatosis assessment: influence of posture and breathing variations. PG - 340 LID - 10.1186/s12880-025-01883-y [doi] LID - 340 AB - BACKGROUND: Given the recent redefinition of metabolic dysfunction-associated steatotic liver disease (MASLD) and the clinical demand for non-invasive tools, this study evaluated the effect of body position (e.g., supine, left lateral recumbent) and respiratory status (e.g., deep inspiration, expiration) on ultrasound-derived fat fraction (UDFF) measurements., assessed their reliability and consistency, and determined the optimal conditions for obtaining UDFF. METHODS: A retrospective analysis was performed using the system with the UDFF algorithm. Two operators performed UDFF measurements in six different scenarios, each consisting of three measurements (18 in total). Consistency analysis was achieved primarily by intragroup correlation coefficients (ICC) and Friedman's test, and Spearman's correlation analysis mainly achieved correlation. RESULTS: 319 participants were included (mean age 40 +/- 17 years; 154 males). The ICC showed strong reliability (mean ICC = 0.999), and Friedman's test showed no significant differences between BMI groups or between the various breathing and postural conditions (p > 0.05). However, the coefficient of variation (Cov), which affects the results, was lowest for supine breath-holding. Spearman's rho showed a strong correlation between supine breath-holding (rho = 0.973) and end-inspiratory and end-expiratory breathing (rho = 0.965). Body mass index was also closely and positively correlated with UDFF (rho = 0.652; p < 0.001), and highly correlated across positions and respiratory states (rho = 0.954-0.973; p < 0.001). CONCLUSION: UDFF demonstrates high reliability and consistency, particularly in the supine breath-hold state, offering a standardized protocol for patients with limited mobility or respiratory distress, such as those with COPD or pediatric populations. In addition, the supine breath-hold state may be a more appropriate measurement condition. FAU - You, Tingjing AU - You T AD - The First Affiliated Hospital of Ningbo University, Ningbo, China. FAU - Zhang, Shengmin AU - Zhang S AD - Department of Ultrasound Medicine, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Ningbo, Zhejiang Province, 315010, China. nbsmzhang@163.com. FAU - Cheng, Shuai AU - Cheng S AD - Department of Ultrasound Medicine, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Ningbo, Zhejiang Province, 315010, China. FAU - Shen, Zhenyu AU - Shen Z AD - Department of Ultrasound Medicine, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Ningbo, Zhejiang Province, 315010, China. LA - eng GR - No. 2023KY1058/The Medical and Health Technology of Zhejiang Province/ GR - No. LBY23H180003/The Natural Science Foundation of Zhejiang Province, China/ PT - Journal Article DEP - 20250820 PL - England TA - BMC Med Imaging JT - BMC medical imaging JID - 100968553 SB - IM MH - Humans MH - Male MH - Reproducibility of Results MH - Ultrasonography/methods MH - Female MH - Adult MH - *Posture MH - Retrospective Studies MH - Middle Aged MH - *Respiration MH - *Fatty Liver/diagnostic imaging MH - Algorithms MH - Aged PMC - PMC12366230 OTO - NOTNLM OT - Hepatic steatosis OT - Liver OT - Posture OT - Respiration OT - Ultrasound COIS- Declarations. Ethics approval and consent to participate: The research was performed in accordance with the Declaration of Helsinki and the Clinical Research Ethics Committee of the First Affiliated Hospital of Ningbo University [No. 2024-212RS] reviewed and approved studies involving human participants. All participants provided written informed consent. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/08/22 16:44 MHDA- 2026/06/27 00:58 PMCR- 2025/08/20 CRDT- 2025/08/21 00:29 PHST- 2025/03/04 00:00 [received] PHST- 2025/08/13 00:00 [accepted] PHST- 2026/06/27 00:58 [medline] PHST- 2025/08/22 16:44 [pubmed] PHST- 2025/08/21 00:29 [entrez] PHST- 2025/08/20 00:00 [pmc-release] AID - 10.1186/s12880-025-01883-y [pii] AID - 1883 [pii] AID - 10.1186/s12880-025-01883-y [doi] PST - epublish SO - BMC Med Imaging. 2025 Aug 20;25(1):340. doi: 10.1186/s12880-025-01883-y. PMID- 40837152 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250914 LR - 20250914 IS - 0970-0218 (Print) IS - 1998-3581 (Electronic) IS - 0970-0218 (Linking) VI - 50 IP - 4 DP - 2025 Jul-Aug TI - Unveiling Childhood Health: A Rural Cross-Sectional Study of Nutritional Status among Under-Five Children in Chengalpattu, Tamil Nadu. PG - 621-628 LID - 10.4103/ijcm.ijcm_398_23 [doi] AB - BACKGROUND: Malnutrition has emerged as a significant global concern, exacerbated by modernization and the pervasive influence of Western culture. Poor dietary habits and lifestyle shifts have rendered populations, particularly children, more vulnerable to both undernutrition and overnutrition. Alterations in dietary patterns among children under 5 years have contributed to a rise in the prevalence of noncommunicable diseases in adulthood, including obesity, diabetes, hypertension, and coronary heart disease. This research aims to assess the prevalence and determinants of malnutrition among children aged 6-59 months in the rural areas of Chengalpattu district. MATERIALS AND METHODS: A cross-sectional study was carried out on 420 children aged 6-59 months in the rural village of Chengalpattu. Multistage random sampling was employed to select participants, and data were collected using a pre-tested, validated semi-structured questionnaire. The data were analyzed using SPSS version 26, and Chi-square tests were performed to assess the associations. The univariate analysis was followed by a multivariate logistic regression to identify significant predictors. RESULTS: Overall rate of malnutrition was 46.2%, with 30.2% stunted, 21% wasted, and 24.3% underweight. Malnutrition was statistically significant with gender, low socioeconomic status, breastfeeding initiation after 1 hour of birth, Integrated Child Development Services beneficiary, mode of delivery, birth order, and parental educational status of the children. CONCLUSION: The study results indicate that undernutrition remains a significant health concern among children under 5 years of age. Addressing issues such as low living standards, hunger, malnutrition, illiteracy, inadequate antenatal care, and poor sanitary and housing facilities is crucial. Effectively implementing existing policies and initiatives aimed at improving these conditions is essential. CI - Copyright: (c) 2025 Indian Journal of Community Medicine. FAU - Sundaram, M Palanivel AU - Sundaram MP AD - Department of Community Medicine, SRM Medical College Hospital and Research Centre, SRMIST, Kattankulathur, Chengalpattu, Tamil Nadu, India. FAU - Kaveri, P AU - Kaveri P AD - Department of Community Medicine, SRM Medical College Hospital and Research Centre, SRMIST, Kattankulathur, Chengalpattu, Tamil Nadu, India. FAU - Kalaivanan, R AU - Kalaivanan R AD - Department of Community Medicine, SRM Medical College Hospital and Research Centre, SRMIST, Kattankulathur, Chengalpattu, Tamil Nadu, India. FAU - Anantharaman, V V AU - Anantharaman VV AD - Department of Community Medicine, SRM Medical College Hospital and Research Centre, SRMIST, Kattankulathur, Chengalpattu, Tamil Nadu, India. FAU - Selvaraj, Preethi AU - Selvaraj P AD - Department of Community Medicine, SRM Medical College Hospital and Research Centre, SRMIST, Kattankulathur, Chengalpattu, Tamil Nadu, India. LA - eng PT - Journal Article DEP - 20250206 PL - India TA - Indian J Community Med JT - Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine JID - 9315574 PMC - PMC12364298 OTO - NOTNLM OT - Malnutrition OT - nutrition status OT - risk factors OT - rural area OT - under-five children COIS- There are no conflicts of interest. EDAT- 2025/08/21 06:28 MHDA- 2025/08/21 06:29 PMCR- 2025/07/01 CRDT- 2025/08/21 05:11 PHST- 2023/06/16 00:00 [received] PHST- 2024/07/03 00:00 [accepted] PHST- 2025/08/21 06:29 [medline] PHST- 2025/08/21 06:28 [pubmed] PHST- 2025/08/21 05:11 [entrez] PHST- 2025/07/01 00:00 [pmc-release] AID - IJCM-50-621 [pii] AID - 10.4103/ijcm.ijcm_398_23 [doi] PST - ppublish SO - Indian J Community Med. 2025 Jul-Aug;50(4):621-628. doi: 10.4103/ijcm.ijcm_398_23. Epub 2025 Feb 6. PMID- 40835794 OWN - NLM STAT- MEDLINE DCOM- 20250820 LR - 20261008 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 184 IP - 9 DP - 2025 Aug 21 TI - Intuitive Eating Scale-2 for adolescents: Validity and reliability study in Turkish adolescents. PG - 566 LID - 10.1007/s00431-025-06412-1 [doi] AB - The Intuitive Eating Scale-2 (IES-2) is currently used for this concept and consists of four sub-dimensions. This cross-sectional study aimed to determine the validity and reliability of the culturally and linguistically adapted IES-2, which examines multiple aspects of eating behavior in adults, in the Turkish adolescent population for the first time. The factor structure of the IES-2 was evaluated in study 1 (n = 300, 57.7% girl) using exploratory factor analysis (EFA), and in study 2 (n = 470, 60.9%) with confirmatory factor analysis (CFA). The Figure Rating Scale (FRS), the Emotional Eating Scale Adapted for Use in Children and Adolescents Scale (EES-C), the Children's Eating Attitudes Test (ChEAT), and BMI-Z score were used to assess convergent validity, and their relationship with IES-2 was examined. Cronbach-alpha, McDonald's omega, Spearman-Brown, and Guttman split-half coefficients were used for reliability analysis. The four-factor structure of the IES-2 was obtained through EFA, and items with low factor loadings were removed. The 15-item version of the scale was created and verified by CFA. The new scale adapted for adolescents is the IES-2-Turkish adolescents (IES-2-TA). Good fit index values were achieved because of CFA. The Cronbach-alpha coefficients for the sub-dimensions (unconditional permission to eat-UPE: 0.649, eating for physical reasons-EPR: 0.683, relying on hunger and satiety cues-RHSC: 0.871, body-food choice congruence-BFCC: 0.751) and total scale (0.789) were found to be at good values. A negative correlation was found between IES-2-TA and ChEAT, as well as EES-C, for convergent validity. CONCLUSION: The analysis of data revealed that the new version of the IES-2-TA is a reliable and valid instrument to assess intuitive eating in Turkish adolescents. WHAT IS KNOWN: * Intuitive eating is an eating behavior that emphasizes internal bodily cues to guide food decisions. * There is no scale to measure intuitive eating in children and adolescents in Turkey. WHAT IS NEW: * This scale (IES-2-TA), adapted from the adult IES-2, is valid and reliable for assessing intuitive eating in Turkish adolescents. CI - (c) 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Ozkan, Nilufer AU - Ozkan N AUID- ORCID: 0000-0002-4900-9714 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Ordu University, 52200, Ordu, Turkey. nozkan_@hotmail.com. FAU - Gonul, Busra Aslan AU - Gonul BA AUID- ORCID: 0000-0002-2365-3069 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Erciyes University, 38000, Kayseri, Turkey. FAU - Baloglu, Hilal Toklu AU - Baloglu HT AUID- ORCID: 0000-0002-0052-4838 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Bitlis Eren University, 13000, Bitlis, Turkey. FAU - Cavdar, Meliha AU - Cavdar M AUID- ORCID: 0000-0001-5122-7860 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Erciyes University, 38000, Kayseri, Turkey. LA - eng PT - Journal Article PT - Validation Study DEP - 20250821 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Adolescent MH - Female MH - Reproducibility of Results MH - Turkey MH - Cross-Sectional Studies MH - Male MH - *Feeding Behavior/psychology MH - Psychometrics MH - Factor Analysis, Statistical MH - Surveys and Questionnaires MH - *Intuition MH - Child MH - *Adolescent Behavior/psychology OTO - NOTNLM OT - Adolescent OT - Intuitive eating OT - Reliability OT - Validity COIS- Declarations. Ethics approval and consent to participate: All procedures conformed to the Declaration of Helsinki, and this study has been approved by the Bitlis Eren University Non-Interventional Ethics Committee (Date: 2024/3-No: 8). We informed administrators, schoolteachers, and parents about the research. We obtained written informed consent forms from the adolescents and their parents, in addition to verbal consent. Competing interests: The authors declare no competing interests. EDAT- 2025/08/21 00:30 MHDA- 2025/08/21 00:31 CRDT- 2025/08/20 23:26 PHST- 2025/06/13 00:00 [received] PHST- 2025/08/11 00:00 [accepted] PHST- 2025/08/02 00:00 [revised] PHST- 2025/08/21 00:31 [medline] PHST- 2025/08/21 00:30 [pubmed] PHST- 2025/08/20 23:26 [entrez] AID - 10.1007/s00431-025-06412-1 [pii] AID - 10.1007/s00431-025-06412-1 [doi] PST - epublish SO - Eur J Pediatr. 2025 Aug 21;184(9):566. doi: 10.1007/s00431-025-06412-1. PMID- 40831470 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250914 LR - 20250914 IS - 2589-5370 (Electronic) IS - 2589-5370 (Linking) VI - 87 DP - 2025 Sep TI - Impact of social protection on child malnutrition and mortality across 46 LMICs: a longitudinal study over two decades with insights from the COVID-19 pandemic. PG - 103414 LID - 10.1016/j.eclinm.2025.103414 [doi] LID - 103414 AB - BACKGROUND: Under-5 mortality and malnutrition are major public health challenges in low- and middle-income countries (LMICs), worsened by crises like the COVID-19 pandemic. Evidence on social protection reducing under-5 mortality in LMICs is limited. We examined the impact of social protection coverage, defined as the proportion of the population covered by any form of social protection, on under-5 mortality, stunting, and wasting across 46 LMICs from 2000 to 2021. METHODS: Our study analyzed 1012 country-year observations. Outcomes included under-5 mortality (deaths per 1000 live births), prevalence of wasting (weight-for-height Z-scores < -2 SD), and stunting (height-for-age Z-scores < -2 SD). Coverage of social protection was defined as the proportion of the population receiving at least one social protection benefit. We used fixed-effects Poisson models with robust standard errors to estimate associations, adjusting for socioeconomic, healthcare, and gender-related variables. Interaction terms captured social protection mitigation effects during COVID-19, and counterfactual scenarios estimated averted deaths. Analyses were disaggregated by sex and age groups. FINDINGS: Social protection coverage prevented an estimated 3.05 million under-5 deaths overall, including 583,590 during the pandemic. Higher coverage was significantly associated with reductions in under-5 mortality (IRR:0.71,95%CI:0.54-0.96), stunting (IRR:0.75,95%CI:0.60-0.94), and wasting (IRR:0.87,95%CI:0.78-0.98). During the COVID-19 pandemic years, social protection led to additional reductions in under-5 mortality (IRR:0.68,95%CI:0.59-0.79) and stunting (IRR:0.74,95%CI:0.57-0.95). Toddler mortality (1-2 years) showed the greatest reduction effects (IRR:0.62,95%CI:0.41-0.95). Females showed slightly stronger effects. Sensitivity and triangulation analyses validated all results. INTERPRETATION: Social protection coverage strongly reduced child mortality, stunting, and wasting in LMICs, with heightened impact during the pandemic years. Scaling up social protection programs can be crucial for reducing health inequities, building child resilience, and advancing child health targets in the future. FUNDING: This study was funded by the Rapid Social Response (RSR) Multidonor Trust Fund at the World Bank. CI - (c) 2025 The Author(s). FAU - Landin Basterra, Elisa AU - Landin Basterra E AD - ISGlobal, Barcelona, Spain. AD - Facultat de Medicina i Ciencies de la Salut, Universitat de Barcelona (UB), Barcelona, Spain. FAU - Gentilini, Ugo AU - Gentilini U AD - Social Protection and Jobs Global Practice, World Bank, USA. FAU - Cavalcanti, Daniella Medeiros AU - Cavalcanti DM AD - Institute of Collective Health, Federal University of Bahia (ISC/UFBA), Center for Data and Knowledge Integration for Health (CIDACS), Oswaldo Cruz Foundation (FIOCRUZ), Brazil. FAU - da Silva, Andrea Ferreira AU - da Silva AF AD - Institute of Collective Health, Federal University of Bahia (ISC/UFBA), Center for Data and Knowledge Integration for Health (CIDACS), Oswaldo Cruz Foundation (FIOCRUZ), Brazil. FAU - de Oliveira Ferreira de Sales, Lucas AU - de Oliveira Ferreira de Sales L AD - Institute of Collective Health, Federal University of Bahia (ISC/UFBA), Center for Data and Knowledge Integration for Health (CIDACS), Oswaldo Cruz Foundation (FIOCRUZ), Brazil. FAU - Silva, Natanael J AU - Silva NJ AD - ISGlobal, Barcelona, Spain. AD - Facultat de Medicina i Ciencies de la Salut, Universitat de Barcelona (UB), Barcelona, Spain. FAU - Rasella, Davide AU - Rasella D AD - ISGlobal, Barcelona, Spain. AD - ICREA, Pg.Lluis Companys 23, Barcelona, Spain. LA - eng PT - Journal Article DEP - 20250812 PL - England TA - EClinicalMedicine JT - EClinicalMedicine JID - 101733727 PMC - PMC12359242 OTO - NOTNLM OT - COVID-19 OT - Child health OT - Child mortality OT - Economic crisis OT - Impact evaluation OT - Low- and middle-income countries OT - Malnutrition OT - Poverty OT - Social protection OT - Stunting OT - Wasting COIS- We declare no competing or conflict of interest. EDAT- 2025/08/20 06:30 MHDA- 2025/08/20 06:31 PMCR- 2025/08/12 CRDT- 2025/08/20 04:55 PHST- 2025/06/19 00:00 [received] PHST- 2025/07/15 00:00 [revised] PHST- 2025/07/23 00:00 [accepted] PHST- 2025/08/20 06:31 [medline] PHST- 2025/08/20 06:30 [pubmed] PHST- 2025/08/20 04:55 [entrez] PHST- 2025/08/12 00:00 [pmc-release] AID - S2589-5370(25)00346-3 [pii] AID - 103414 [pii] AID - 10.1016/j.eclinm.2025.103414 [doi] PST - epublish SO - EClinicalMedicine. 2025 Aug 12;87:103414. doi: 10.1016/j.eclinm.2025.103414. eCollection 2025 Sep. PMID- 40829986 OWN - NLM STAT- MEDLINE DCOM- 20251216 LR - 20260526 IS - 1873-4898 (Electronic) IS - 1477-5131 (Linking) VI - 21 IP - 6 DP - 2025 Dec TI - Early outcomes and risk factors for complications following pediatric neurogenic bladder reconstruction: A secondary analysis of the pediatric NSQIP database (2015-2020). PG - 1851-1858 LID - S1477-5131(25)00415-2 [pii] LID - 10.1016/j.jpurol.2025.07.030 [doi] AB - INTRODUCTION: Surgical management of pediatric neurogenic bladder (NB) and bowel aims to achieve safe filling pressures and achieve dryness, simultaneously allowing independence to manage voiding functions. The surgical armamentarium includes; augmentation cystoplasty (AC), bladder neck reconstruction (BNR), Mitrofanoff procedure (MP) and cecostomy (MACE). Often, patients undergo these procedures concomitantly, based on urodynamic and clinical findings. OBJECTIVE: This study aims to determine the 30-day outcomes of pediatric NB reconstructive surgery, and identify independent risk factors for an early adverse outcome. STUDY DESIGN: This study is a secondary analysis of prospectively collected data from the National Surgical Quality Improvement Program (NSQIP) Pediatric database between 2015 and 2020. Patients <18 years of age with an International Classification of Disease, Ninth and Tenth Revision (ICD-9/10) diagnosis of Spina Bifida (SB) undergoing a urological reconstruction defined with specific Current Procedural Terminology (CPT) codes were included. Patient demographics, perioperative variables, operative timing, length of stay, 30-day readmission/reoperation data and surgical complications were assessed. Patients were categorized into four surgical groups: 1: MP only; 2: isolated BNR; 3: AC +/- MP; 4: AC + BNR + MP +/- MACE. A multivariable logistic regression analysis was conducted to identify risk factors for 30-day readmission and re-operation using age, body mass index (BMI), operative time and surgical groups as independent variables. RESULTS: We identified a cohort of 700 patient encounters involving at least one of these procedures, with a median age at surgery of 10.3 years (Interquartile Range [IQR] 6.6-13.6). The majority were females (58.3 %) and 53.6 % had a normal BMI, 18.3 % were overweight and 28.1 % were obese. The overall early complication rate ranged from 14.8 % to 27.2 %, with a 15.1 % readmission rate and reoperation rate was 7.9 % following pediatric NB reconstruction. Multivariable logistic regression analysis indicated that those in surgical group 4 were 2.78 times (95 % CI-1.03 - 7.49) more likely for 30-day readmission, compared to Group 1 (p = .04). Multivariable analysis revealed no significant predictors of 30-day reoperation. DISCUSSION: Age at surgery, BMI and operative time do not predict the risk of surgical complications following NB reconstruction. We validated that increasing procedure count was associated with increased risk of 30-day readmission. CONCLUSION: Increasing the number of surgical interventions for NB reconstruction is associated with higher 30-day readmission rates, while increasing age at surgery and BMI did not predict readmission or reoperation. The results of this study are generalizable, given the cohort, and can help pediatric urologists prognosticate early patient outcomes following major NB reconstructive surgeries. CI - Copyright (c) 2025 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved. FAU - Aly, Mohamed AU - Aly M AD - Schulich School of Medicine and Dentistry, Western University, Canada. FAU - Wilson, Claire A AU - Wilson CA AD - Division of Paediatric Surgery, Children's Hospital, London Health Sciences Centre, Canada. FAU - Davidson, Jacob AU - Davidson J AD - Division of Paediatric Surgery, Children's Hospital, London Health Sciences Centre, Canada. FAU - Matti, Danny AU - Matti D AD - Division of Paediatric Surgery, Children's Hospital, London Health Sciences Centre, Canada; Division of Urology, Western University, Canada. FAU - Wang, Peter AU - Wang P AD - Schulich School of Medicine and Dentistry, Western University, Canada; Division of Urology, Western University, Canada. FAU - Dave, Sumit AU - Dave S AD - Schulich School of Medicine and Dentistry, Western University, Canada; Division of Urology, Western University, Canada. Electronic address: Sumit.Dave@lhsc.on.ca. LA - eng PT - Journal Article DEP - 20250807 PL - England TA - J Pediatr Urol JT - Journal of pediatric urology JID - 101233150 SB - IM MH - Humans MH - *Urinary Bladder, Neurogenic/surgery/etiology MH - Child MH - Risk Factors MH - Female MH - Male MH - *Postoperative Complications/epidemiology/etiology MH - Databases, Factual MH - Adolescent MH - *Plastic Surgery Procedures/methods/adverse effects MH - *Urologic Surgical Procedures/methods/adverse effects MH - Treatment Outcome MH - Child, Preschool MH - Time Factors MH - Retrospective Studies MH - Infant MH - Quality Improvement MH - Urinary Bladder/surgery OTO - NOTNLM OT - Appendico-vesicostomy OT - Bladder augmentation OT - Neurogenic bladder OT - Spina bifida OT - Surgical complications COIS- Conflict of interest All authors declare no conflict of interest. EDAT- 2025/08/20 00:29 MHDA- 2025/12/16 06:28 CRDT- 2025/08/19 21:56 PHST- 2025/02/04 00:00 [received] PHST- 2025/07/18 00:00 [revised] PHST- 2025/07/28 00:00 [accepted] PHST- 2025/12/16 06:28 [medline] PHST- 2025/08/20 00:29 [pubmed] PHST- 2025/08/19 21:56 [entrez] AID - S1477-5131(25)00415-2 [pii] AID - 10.1016/j.jpurol.2025.07.030 [doi] PST - ppublish SO - J Pediatr Urol. 2025 Dec;21(6):1851-1858. doi: 10.1016/j.jpurol.2025.07.030. Epub 2025 Aug 7. PMID- 40829948 OWN - NLM STAT- MEDLINE DCOM- 20251215 LR - 20251215 IS - 1468-2079 (Electronic) IS - 0007-1161 (Linking) VI - 110 IP - 1 DP - 2025 Dec 15 TI - Dietary omega-3 polyunsaturated fatty acids as a protective factor of myopia: the Hong Kong Children Eye Study. PG - 101-106 LID - 10.1136/bjo-2024-326872 [doi] AB - PURPOSE: To evaluate the associations between omega-3 polyunsaturated fatty acids (omega-3 PUFAs) and other dietary factors with myopia. METHODS: A total of 1005 Chinese children, aged from 6 to 8 years, from a population-based Hong Kong Children Eye Study, were included in the analysis. Diet was assessed using a validated food-frequency questionnaire. Cycloplegic spherical equivalent (SE) refraction was assessed with an autorefractometer, and axial length (AL) by an IOL Master. RESULTS: AL was longest in the lowest quartile group of omega-3 PUFAs intake, compared with the highest (adjusted mean (95% CI), 23.29 (23.17 to 23.40) mm vs 23.08 (22.96 to 23.19) mm, p=0.01; p-trend=0.02) after adjusting for age, sex, body mass index, near-work time, outdoor time, and parental myopia history. The corresponding trends were observed in SE (-0.13 (-0.32 to 0.07) D in the lowest and 0.23 (0.03 to 0.42) D in the highest quartile groups, p=0.01; p-trend=0.01). In contrast, AL was longest in the highest quartile group of saturated fatty acids (SFA) intake, compared with the lowest (23.30 (23.17 to 23.42) mm vs 23.13 (23.01 to 23.24) mm, p=0.05; p-trend=0.04). The corresponding trends were observed in SE (-0.12 (-0.33 to 0.09) D in the highest and 0.13 (-0.04 to 0.31) D in the lowest quartile group, p=0.06; p-trend=0.04). A lower intake of omega-3 PUFAs was associated with myopia (p-trend=0.006). None of the other nutrients were associated with SE or AL or myopia. CONCLUSIONS: Intake of omega-3 PUFAs is a protective factor against myopia, while higher SFA intake is a risk factor. Our findings indicated a possible effect of diet on myopia, of which omega-3 PUFAs intake may play a protective role against myopia development in children. CI - (c) Author(s) (or their employer(s)) 2026. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Zhang, Xiu Juan AU - Zhang XJ AUID- ORCID: 0000-0002-4197-1423 AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. AD - Department of Ophthalmology, The University of Hong Kong, Hong Kong SAR, People's Republic of China. FAU - Zhang, Yuzhou AU - Zhang Y AUID- ORCID: 0000-0001-8515-3388 AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. FAU - Zhang, You Juan AU - Zhang YJ AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. AD - Department of Applied Social Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, People's Republic of China. FAU - Yu, Jun AU - Yu J AUID- ORCID: 0009-0006-3920-9321 AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. FAU - Tang, Fang Yao AU - Tang FY AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. AD - Institute of Ophthalmology, University College London, London, UK. FAU - Li, Yi AU - Li Y AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. FAU - Yeung, Suey AU - Yeung S AD - Jockey Club Institute of Ageing, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. FAU - Kam, Ka Wai AU - Kam KW AUID- ORCID: 0000-0002-7760-6882 AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. AD - Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong SAR, People's Republic of China. FAU - Agrawal, Kunal AU - Agrawal K AD - Department of Computer Science, University of Dayton, Dayton, Ohio, USA. FAU - Loh, Nicholas Chieh AU - Loh NC AD - Yong Loo Lin School of Medicine, National University of Singapore, Singapore. FAU - Ip, Patrick AU - Ip P AD - Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China. FAU - Wong, Ian Ck AU - Wong IC AD - Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, People's Republic of China. FAU - Zhang, Wei AU - Zhang W AD - Tianjin Eye Hospital, Tianjin, China. FAU - Young, Alvin L AU - Young AL AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. AD - Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong SAR, People's Republic of China. FAU - Tham, Clement C AU - Tham CC AUID- ORCID: 0000-0003-4407-6907 AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. AD - Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong SAR, People's Republic of China. AD - Hong Kong Eye Hospital, Hong Kong SAR, People's Republic of China. AD - Department of Ophthalmology, Hong Kong Children Hospital, Hong Kong SAR, People's Republic of China. AD - Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. FAU - Pang, Chi Pui AU - Pang CP AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. AD - Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. FAU - Chen, Li Jia AU - Chen LJ AUID- ORCID: 0000-0003-3500-5840 AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. AD - Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong SAR, People's Republic of China. AD - Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. FAU - Yam, Jason C AU - Yam JC AUID- ORCID: 0000-0002-2156-1486 AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China yamcheuksing@cuhk.edu.hk. AD - Hong Kong Eye Hospital, Hong Kong SAR, People's Republic of China. AD - Department of Ophthalmology, Hong Kong Children Hospital, Hong Kong SAR, People's Republic of China. AD - Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. LA - eng PT - Journal Article DEP - 20251215 PL - England TA - Br J Ophthalmol JT - The British journal of ophthalmology JID - 0421041 RN - 0 (Fatty Acids, Omega-3) SB - IM MH - Humans MH - *Fatty Acids, Omega-3/administration & dosage MH - Male MH - Female MH - Child MH - *Myopia/prevention & control/epidemiology/physiopathology MH - Hong Kong/epidemiology MH - Refraction, Ocular/physiology MH - *Diet MH - Axial Length, Eye MH - Protective Factors MH - Surveys and Questionnaires MH - Risk Factors MH - Cross-Sectional Studies OTO - NOTNLM OT - Child health (paediatrics) OT - Epidemiology COIS- Competing interests: None declared. EDAT- 2025/08/20 00:29 MHDA- 2025/12/16 00:34 CRDT- 2025/08/19 21:53 PHST- 2024/12/05 00:00 [received] PHST- 2025/06/30 00:00 [accepted] PHST- 2025/12/16 00:34 [medline] PHST- 2025/08/20 00:29 [pubmed] PHST- 2025/08/19 21:53 [entrez] AID - bjo-2024-326872 [pii] AID - 10.1136/bjo-2024-326872 [doi] PST - epublish SO - Br J Ophthalmol. 2025 Dec 15;110(1):101-106. doi: 10.1136/bjo-2024-326872. PMID- 40829824 OWN - NLM STAT- MEDLINE DCOM- 20250819 LR - 20250823 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 8 DP - 2025 Aug 19 TI - Application of machine learning in early childhood development research: a scoping review. PG - e100358 LID - 10.1136/bmjopen-2025-100358 [doi] LID - e100358 AB - BACKGROUND: Early childhood development (ECD) lays the foundation for lifelong health, academic success and social well-being, yet over 250 million children in low- and middle-income countries are at risk of not reaching their developmental potential. Traditional measures fail to fully capture the risks associated with a child's development outcomes. Artificial intelligence techniques, particularly machine learning (ML), offer an innovative approach by analysing complex datasets to detect subtle developmental patterns. OBJECTIVE: To map the existing literature on the use of ML in ECD research, including its geographical distribution, to identify research gaps and inform future directions. The review focuses on applied ML techniques, data types, feature sets, outcomes, data splitting and validation strategies, model performance, model explainability, key themes, clinical relevance and reported limitations. DESIGN: Scoping review using the Arksey and O'Malley framework with enhancements by Levac et al. DATA SOURCES: A systematic search was conducted on 16 June 2024 across PubMed, Web of Science, IEEE Xplore and PsycINFO, supplemented by grey literature (OpenGrey) and reference hand-searching. No publication date limits were applied. ELIGIBILITY CRITERIA: Included studies applied ML or its variants (eg, deep learning (DL), natural language processing) to developmental outcomes in children aged 0-8 years. Studies were in English and addressed cognitive, language, motor or social-emotional development. Excluded were studies focusing on robotics; neurodevelopmental disorders such as autism spectrum disorder, attention-deficit/hyperactivity disorder and communication disorders; disease or medical conditions; and review articles. DATA EXTRACTION AND CHARTING: Three reviewers independently extracted data using a structured MS Excel template, covering study ML techniques, data types, feature sets, outcomes, outcome measures, data splitting and validation strategies, model performance, model explainability, key themes, clinical relevance and limitations. A narrative synthesis was conducted, supported by descriptive statistics and visualisations. RESULTS: Of the 759 articles retrieved, 27 met the inclusion criteria. Most studies (78%) originated from high-income countries, with none from sub-Saharan Africa. Supervised ML classifiers (40.7%) and DL techniques (22.2%) were the most used approaches. Cognitive development was the most frequently targeted outcome (33.3%), often measured using the Bayley Scales of Infant and Toddler Development-III (33.3%). Data types varied, with image, video and sensor-based data being most prevalent. Key predictive features were grouped into six categories: brain features; anthropometric and clinical/biological markers; socio-demographic and environmental factors; medical history and nutritional indicators; linguistic and expressive features; and motor indicators. Most studies (74.1%) focused solely on prediction, with the majority conducting predictions at age 2 years and above. Only 41% of studies employed explainability methods, and validation strategies varied widely. Few studies (7.4%) conducted external validation, and only one had progressed to a clinical trial. Common limitations included small sample sizes, lack of external validation and imbalanced datasets. CONCLUSION: There is growing interest in using ML for ECD research, but current research lacks geographical diversity, external validation, explainability and practical implementation. Future work should focus on developing inclusive, interpretable and externally validated models that are integrated into real-world implementation. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Benson, Faith Neema AU - Benson FN AUID- ORCID: 0000-0002-4773-9684 AD - Institute for Human Development, The Aga Khan University, Nairobi, Kenya faith.neema@aku.edu. AD - Department of Mathematical Sciences, Stellenbosch University, Stellenbosch, South Africa. FAU - Chelangat, Daisy AU - Chelangat D AD - Institute for Human Development, The Aga Khan University, Nairobi, Kenya. FAU - Brink, Willie AU - Brink W AD - Department of Mathematical Sciences, Stellenbosch University, Stellenbosch, South Africa. FAU - Mwangala, Patrick N AU - Mwangala PN AD - Institute for Human Development, The Aga Khan University, Nairobi, Kenya. FAU - Waljee, Akbar K AU - Waljee AK AD - Department of Learning Health Sciences, University of Michigan, Ann Arbor, Michigan, USA. AD - Center for Global Health Equity, University of Michigan, Ann Arbor, Michigan, USA. FAU - Moyer, Cheryl A AU - Moyer CA AD - Department of Learning Health Sciences, University of Michigan, Ann Arbor, Michigan, USA. AD - Center for Global Health Equity, University of Michigan, Ann Arbor, Michigan, USA. FAU - Abubakar, Amina AU - Abubakar A AUID- ORCID: 0000-0002-3686-7904 AD - Institute for Human Development, The Aga Khan University, Nairobi, Kenya. AD - Department of Psychiatry, University of Oxford, Oxford, UK. AD - Neuroscience Unit, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. LA - eng GR - U54 TW012089/TW/FIC NIH HHS/United States PT - Journal Article PT - Scoping Review DEP - 20250819 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Child Development MH - *Machine Learning MH - Child, Preschool MH - Child MH - Infant PMC - PMC12366570 OTO - NOTNLM OT - Child OT - Cognition OT - Machine Learning COIS- Competing interests: None declared. EDAT- 2025/08/20 00:29 MHDA- 2025/08/20 00:30 PMCR- 2025/08/19 CRDT- 2025/08/19 20:42 PHST- 2025/08/20 00:30 [medline] PHST- 2025/08/20 00:29 [pubmed] PHST- 2025/08/19 20:42 [entrez] PHST- 2025/08/19 00:00 [pmc-release] AID - bmjopen-2025-100358 [pii] AID - 10.1136/bmjopen-2025-100358 [doi] PST - epublish SO - BMJ Open. 2025 Aug 19;15(8):e100358. doi: 10.1136/bmjopen-2025-100358. PMID- 40826131 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20250914 LR - 20250914 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 13 IP - 1 DP - 2025 Aug 18 TI - Avoidant restrictive food intake disorder (ARFID) in Swedish preschool children: a screening study. PG - 179 LID - 10.1186/s40337-025-01369-w [doi] LID - 179 AB - BACKGROUND: Despite its common early onset, little is known about the prevalence and clinical presentation of avoidant restrictive food intake disorder (ARFID) in very young children, hindering early identification and intervention. Differentiating ARFID from normative selective eating is particularly challenging, yet validated parent-reported screening tools are lacking. This study aimed to estimate the point prevalence and describe the clinical characteristics of ARFID in preschoolers. It also evaluated the psychometric properties of the parent-reported ARFID-Brief Screener by assessing its agreement with a diagnostic interview for ARFID. METHODS: Parents of 645 children (50.5% male, mean age 3.2 years) completed the ARFID-Brief Screener and a neurodevelopmental screener during 2.5- and 4-year routine check-ups at 21 child health centers in West Sweden. Parents of all screen-positive and of randomly selected screen-negative children were invited to a follow-up diagnostic interview via phone. Additional clinical data were extracted from health records. RESULTS: Of the 42 children (6.5%) who screened positive for ARFID, 29 were followed up via diagnostic interview, and 21 received an ARFID diagnosis, yielding a positive predictive value of 72%. Negative predictive value, sensitivity, specificity, and overall accuracy of the ARFID-Brief Screener were 94%, 91%, 79%, and 84%, respectively. The estimated point prevalence of ARFID was 5.9%. All diagnosed children exhibited both sensory-based avoidance and low interest in eating. Only 13.5% met ARFID criteria based on weight- or nutrition-related impairment (DSM-5 Criteria A1-A3). Two fifths (39.1%) of children with ARFID exhibited early language delays compared to 13.5% of children without ARFID. More extensive neurodevelopmental problems were associated with greater ARFID severity and with higher scores on the sensory and concern profiles. CONCLUSIONS: ARFID is not uncommon among preschoolers, though prevalence may be slightly overestimated in this study. It is primarily characterized by sensory-based avoidance and low interest in eating, and by psychosocial impairment instead of physical health consequences, underscoring the need to assess impact beyond weight, growth, and nutrition. Early neurodevelopmental difficulties are overrepresented, highlighting their relevance for early detection and intervention. The ARFID-Brief Screener demonstrated promising psychometric properties and may be a valuable tool for routine screening, though follow-up assessments remain necessary to confirm a diagnoses. CI - (c) 2025. The Author(s). FAU - Dinkler, Lisa AU - Dinkler L AUID- ORCID: 0000-0002-9901-4984 AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels Vag 12A, 17177, Stockholm, Sweden. lisa.dinkler@ki.se. AD - Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. lisa.dinkler@ki.se. AD - Department of Environmental Medicine, Kochi Medical School, Kochi University, Kochi, Japan. lisa.dinkler@ki.se. FAU - Brimo, Katarzyna AU - Brimo K AUID- ORCID: 0009-0007-1086-8769 AD - Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. FAU - Holmang, Helena AU - Holmang H AUID- ORCID: 0009-0004-0016-6980 AD - Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. FAU - Yasumitsu-Lovell, Kahoko AU - Yasumitsu-Lovell K AUID- ORCID: 0000-0002-8379-3514 AD - Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. AD - Department of Environmental Medicine, Kochi Medical School, Kochi University, Kochi, Japan. AD - Kochi Gillberg Neuropsychiatry Centre, Kochi, Japan. FAU - Kuja-Halkola, Ralf AU - Kuja-Halkola R AUID- ORCID: 0000-0002-3765-2067 AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels Vag 12A, 17177, Stockholm, Sweden. FAU - Kantzer, Anne-Katrin AU - Kantzer AK AUID- ORCID: 0000-0002-3960-6398 AD - Child and Adolescent Psychiatry, NU Hospital Group, Trollhattan, Sweden. FAU - Omanovic, Zerina AU - Omanovic Z AD - Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. FAU - Suganuma, Narufumi AU - Suganuma N AUID- ORCID: 0000-0003-1610-6216 AD - Department of Environmental Medicine, Kochi Medical School, Kochi University, Kochi, Japan. FAU - Eitoku, Masamitsu AU - Eitoku M AUID- ORCID: 0000-0002-1715-9670 AD - Department of Environmental Medicine, Kochi Medical School, Kochi University, Kochi, Japan. FAU - Fujieda, Mikiya AU - Fujieda M AUID- ORCID: 0000-0002-8975-0400 AD - Department of Pediatrics, Kochi Medical School, Kochi University, Kochi, Japan. FAU - Fernell, Elisabeth AU - Fernell E AUID- ORCID: 0000-0003-4516-7747 AD - Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. FAU - Mollborg, Per AU - Mollborg P AUID- ORCID: 0000-0002-2742-6154 AD - Department of Paediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Bryant-Waugh, Rachel AU - Bryant-Waugh R AUID- ORCID: 0000-0002-7449-6059 AD - Maudsley Centre for Child and Adolescent Eating Disorders, South London and Maudsley NHS Foundation Trust, London, UK. AD - Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. FAU - Gillberg, Christopher AU - Gillberg C AUID- ORCID: 0000-0001-8848-1934 AD - Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. AD - Kochi Gillberg Neuropsychiatry Centre, Kochi, Japan. FAU - Rastam, Maria AU - Rastam M AUID- ORCID: 0000-0003-0819-3946 AD - Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. AD - Department of Clinical Sciences Lund, Lund University, Lund, Sweden. LA - eng GR - 2019; 2020/Professor Bror Gadelius Memorial Foundation/ GR - PG-22-0478/Svenska Sallskapet for Medicinsk Forskning/ GR - JP18KK0263/Japan Society for the Promotion of Science KAKENHI/ GR - 538-2013-8864/Vetenskapsradet/ GR - 2018-02544/Vetenskapsradet/ GR - 2018/AnnMari och Per Ahlqvists Stiftelse/ GR - FO2020-0140/Hjarnfonden/ PT - Journal Article DEP - 20250818 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC12363052 OAB - Avoidant restrictive food intake disorder (ARFID) often starts early in life, but little is known about how common it is in very young children. This study looked at how many preschool-aged children have ARFID and what their eating difficulties look like. We also tested how well a short parent questionnaire, the ARFID-Brief Screener, can help identify children at risk. Parents of 645 Swedish children filled out the screener during routine health check-ups at age 2.5 or 5. Children who screened positive and a randomly selected group of screen-negative children were invited to a follow-up interview. Based on these interviews, we estimated that about 5.9% of preschoolers may have ARFID. All children with ARFID avoided food due to sensory sensitivities or had little interest in eating. Few had weight or nutrition problems, but many experienced difficulties in daily life, such as stressful mealtimes. Children with ARFID were more likely to have early neurodevelopmental challenges such as delayed language development, suggesting that these symptoms may aid in identifying children at risk for ARFID. the ARFID-Brief Screener performed well in detecting at-risk children, but follow-up assessments are still needed to confirm a diagnosis. OABL- eng OTO - NOTNLM OT - Children OT - Comorbidity OT - Eating disorders OT - Epidemiology OT - Feeding disorders OT - General population COIS- Declarations. Ethics approval and consent to participate: The study was approved by Swedish Ethical Review Authority (no. 2020-01284, 2020-03908, 2021-01849). All participants gave written informed consent. All methods were conducted in compliance with the applicable guidelines and regulations. Consent for publication: Not applicable. Competing interests: LD reports speaker fees from Baxter Medical AB and Fresenius Kabi AB outside the submitted work. Other authors declare that they have no competing interests. EDAT- 2025/08/19 00:28 MHDA- 2025/08/19 00:29 PMCR- 2025/08/18 CRDT- 2025/08/18 23:39 PHST- 2025/02/02 00:00 [received] PHST- 2025/08/05 00:00 [accepted] PHST- 2025/08/19 00:29 [medline] PHST- 2025/08/19 00:28 [pubmed] PHST- 2025/08/18 23:39 [entrez] PHST- 2025/08/18 00:00 [pmc-release] AID - 10.1186/s40337-025-01369-w [pii] AID - 1369 [pii] AID - 10.1186/s40337-025-01369-w [doi] PST - epublish SO - J Eat Disord. 2025 Aug 18;13(1):179. doi: 10.1186/s40337-025-01369-w. PMID- 40825898 OWN - NLM STAT- MEDLINE DCOM- 20250826 LR - 20261008 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 184 IP - 9 DP - 2025 Aug 18 TI - Reliability and validity evidence for the physical activity parenting questionnaire for children (PAP-C) in Chinese school-aged children. PG - 561 LID - 10.1007/s00431-025-06413-0 [doi] AB - The physical activity parenting questionnaire for children (PAP-C) is designed to assess physical activity parenting practices from children's perspectives. While initially developed in Finland, its validity and reliability have not been evaluated in different countries. This study aimed to examine the construct validity, factorial invariance, and 4-week reliability of the PAP-C in Chinese 7- to 11-year-old children. The PAP-C contains three theory-driven parenting dimensions: structure for activity, autonomy support, and involvement, with 22 items. The construct validity and internal consistency were tested by confirmatory factor analysis (CFA) and composite reliability in a sample of 2747 Chinese school-aged children (grades 1-6, mean age 9.1 +/- 1.4 years, 48.9% girls). Factorial invariance across grades was explored via sequential multi-group CFA, and intra-class correlation (ICC) coefficients were calculated for a subsample of 865 children who completed a 4-week retest (mean age 8.7 +/- 1.1 years, 47.5% girls). The PAP-C with 20 items showed high standardized factor loadings, with good to excellent internal consistency (alpha(a) = 0.86, 0.76, 0.83) for structure for activity (10 items), autonomy support (4 items), and involvement (6 items), respectively. The factor structure exhibited strong stability, with robust fit indices confirming configural, metric, and scalar invariance. The ICCs (0.692-0.909) demonstrated good to excellent test‒retest stability for all grades. CONCLUSION: The PAP-C is a valid and reliable instrument for assessing children's perceptions of physical activity parenting in Chinese school-aged children. The integration of the PAP-C with parental counseling can facilitate a more holistic assessment of physical activity parenting, a key determinant shaping children's physical activity behavior. WHAT IS KNOWN: * Physical activity parenting is a key determinant of children's physical activity. * Few theory-driven child-reported physical activity parenting scales exist, with significant cultural limitations and lacking cross-national validation. WHAT IS NEW: * The physical activity parenting questionnaire for children (PAP-C) shows excellent construct validity and reliability in Chinese school-aged children. * Recognizing the child's perspective on physical activity parenting enables the design of child-centered physical activity interventions in pediatric clinical settings. CI - (c) 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Gao, Ying AU - Gao Y AD - Department of Sports Science, College of Education, Zhejiang University, Hangzhou, China. yigao@zju.edu.cn. FAU - Li, Yijia AU - Li Y AD - Department of Sports Science, College of Education, Zhejiang University, Hangzhou, China. FAU - Zhao, Hanhua AU - Zhao H AD - Department of Sports Science, College of Education, Zhejiang University, Hangzhou, China. FAU - Wang, Di AU - Wang D AD - Department of Sports Science, College of Education, Zhejiang University, Hangzhou, China. FAU - Saakslahti, Arja AU - Saakslahti A AD - Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland. FAU - Aunola, Kaisa AU - Aunola K AD - Department of Psychology, Faculty of Education and Psychology, University of Jyvaskyla, Jyvaskyla, Finland. FAU - Korhonen, Elisa AU - Korhonen E AD - Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland. FAU - Laukkanen, Arto AU - Laukkanen A AD - Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland. LA - eng GR - 82111530074/National Natural Science Foundation of China/ PT - Journal Article PT - Validation Study DEP - 20250818 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - Chinese people SB - IM MH - Humans MH - Child MH - Female MH - Reproducibility of Results MH - Male MH - Surveys and Questionnaires MH - *Exercise/psychology MH - *Parenting/psychology MH - China MH - Psychometrics MH - Factor Analysis, Statistical MH - East Asian People OTO - NOTNLM OT - Autonomy support OT - Children OT - Involvement OT - Parenting OT - Physical activity OT - Structure for activity COIS- Declarations. Ethics approval: This study was approved by the Ethical Review Committee of the Medical College of Zhejiang University (No. 2020-041) and was conducted in agreement with the Declaration of Helsinki. Consent to participate: All participants and their guardians signed a written informed consent form before the start of the study and were informed that participation in this study was completely voluntary, that they had the right to withdraw anytime, and that there would be no adverse consequences of withdrawal. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/08/19 00:28 MHDA- 2025/08/31 20:08 CRDT- 2025/08/18 23:21 PHST- 2025/02/06 00:00 [received] PHST- 2025/08/11 00:00 [accepted] PHST- 2025/08/04 00:00 [revised] PHST- 2025/08/31 20:08 [medline] PHST- 2025/08/19 00:28 [pubmed] PHST- 2025/08/18 23:21 [entrez] AID - 10.1007/s00431-025-06413-0 [pii] AID - 10.1007/s00431-025-06413-0 [doi] PST - epublish SO - Eur J Pediatr. 2025 Aug 18;184(9):561. doi: 10.1007/s00431-025-06413-0. PMID- 40824275 OWN - NLM STAT- MEDLINE DCOM- 20250914 LR - 20260916 IS - 2471-254X (Electronic) IS - 2471-254X (Linking) VI - 9 IP - 9 DP - 2025 Sep 1 TI - Ultrasound of the rectus femoris as a novel tool to measure sarcopenia in pediatric chronic liver disease. LID - 10.1097/HC9.0000000000000799 [doi] LID - e0799 AB - BACKGROUND: Sarcopenia, assessed by psoas muscle CT or MRI, predicts adverse outcomes in adults with advanced chronic liver disease (CLD). However, these radiologic techniques are understudied in children. Ultrasound (US) measures of leg muscle quality and quantity potentially offer a novel, safe, and practical means to assess sarcopenia in pediatric patients. METHODS: We prospectively enrolled pediatric patients (age /=0.70), and data were analyzed using descriptive statistics and chi-square tests. RESULTS: Although 83% of students rated PE as equally important as other academic subjects, 70.7% reported receiving only one hour per week. Students with more PE exposure were significantly more likely to engage in extracurricular PA, value PA, and feel that they have more accessible and supportive opportunities for sports participation in their surroundings (p < 0.01). Cross-group comparisons revealed perceptual gaps in students who reported lower environmental support than teachers and administrators (p = 0.003). While PE teachers were seen as encouraging in class, their influence outside scheduled hours was less evident. Students noted institutional barriers, including frequent cancellations of PE classes and limited extracurricular support. Nonetheless, enjoyment of PE remained high, with most barriers viewed as having only a minor impact. CONCLUSION: These findings highlight the need for expanded PE hours, more substantial institutional commitment, and coordinated stakeholder action to foster an active school culture in Israel. However, limitations such as the modest sample size and the geographic concentration in East Jerusalem may affect the generalizability of the findings. CI - (c) 2025 Alayan, Salhab, Carmel and HaCohen. FAU - Alayan, Ali AU - Alayan A AD - Department of Education, Adam Mickiewicz University, Poznan, Poland. FAU - Salhab, Ahmad AU - Salhab A AD - Department of Science, David Yellin Academic College of Education, Jerusalem, Israel. FAU - Carmel, Paz AU - Carmel P AD - Department of Adult Education, David Yellin College of Education, Jerusalem, Israel. FAU - HaCohen, Ronit Ahdut AU - HaCohen RA AD - Department of Science, David Yellin Academic College of Education, Jerusalem, Israel. LA - eng PT - Journal Article DEP - 20250801 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC12355816 OTO - NOTNLM OT - Israeli education system OT - physical education OT - school-based physical activity OT - stakeholder attitudes OT - student perceptions COIS- The authors declare that the study was conducted without commercial or financial relationships that could create a conflict of interest. EDAT- 2025/08/18 12:32 MHDA- 2025/08/18 12:33 PMCR- 2025/08/01 CRDT- 2025/08/18 07:06 PHST- 2025/05/12 00:00 [received] PHST- 2025/07/14 00:00 [accepted] PHST- 2025/08/18 12:33 [medline] PHST- 2025/08/18 12:32 [pubmed] PHST- 2025/08/18 07:06 [entrez] PHST- 2025/08/01 00:00 [pmc-release] AID - 10.3389/fspor.2025.1625231 [doi] PST - epublish SO - Front Sports Act Living. 2025 Aug 1;7:1625231. doi: 10.3389/fspor.2025.1625231. eCollection 2025. PMID- 40819025 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1471-230X (Electronic) IS - 1471-230X (Linking) VI - 25 IP - 1 DP - 2025 Aug 16 TI - Development of nomogram model based on LASSO-Logistic regression for predicting postoperative undernutrition to complex anorectal malformation: a pilot exploratory study. PG - 588 LID - 10.1186/s12876-025-04202-5 [doi] LID - 588 AB - BACKGROUND: Nutritional problems in patients with anorectal malformation (ARM) after anorectoplasty have not received sufficient attention. This study aimed to establish prediction model of postoperative undernutrition for patients with complex ARM. METHODS: Retrospective review of 104 patients with complex ARM was conducted with assessments of clinical data. Lasso-Logistic regression analysis was used to identify independent factors, and then establish a Nomogram model for predicting postoperative undernutrition. Harrell's concordance index and calibration curves were applied to evaluate the performance of this model. R software was used for statistical analysis. RESULTS: Of the 104 patients, the proportion of malnutrition was 28.85% (30/104). Lasso-Logistic regression analysis showed that non-parental caregivers (Odds ratio [OR]: 11.20), undernutrition at anorectoplasty (OR: 4.101), surgery for other systemic malformation (OR: 8.378), and feeding method (artificial, OR: 25.320) were independently associated with postoperative undernutrition (all P < 0.05), and Nomogram model was developed based on these determinants. The area under the receiver operator characteristic curve of this cohort was 0.877 and it still was 0.906 through bootstrapping validation (n = 1000). The H-L goodness-of-fit test showed that there was no significant difference between the predicted and actual incidence of postoperative undernutrition (chi2 = 7.55, P = 0.273). Meanwhile, the calibration curves indicated that the forecast was in good agreement with the actual situation. Decision curve showed that when the probability threshold of Nomogram model predicting malnutrition was >0.03, application of the model would add net benefit compared to either the treat-all strategy or the treat-none strategy. CONCLUSION : This Nomogram model for predicting postoperative undernutrition of complex ARM patients showed desirable accuracy and discrimination for clinicians, aiding the early initiation of preventative interventions for undernutrition. FAU - Feng, Wei AU - Feng W AD - Department of General & Neonatal Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, China. FAU - Fan, Linxiao AU - Fan L AD - Department of General & Neonatal Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, China. FAU - Hou, Jinping AU - Hou J AD - Department of General & Neonatal Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, China. FAU - Die, Xiaohong AU - Die X AD - Department of General & Neonatal Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, China. FAU - Wang, Yi AU - Wang Y AD - Department of General & Neonatal Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, China. FAU - Jiang, Rui AU - Jiang R AD - Department of Anesthesiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, China. jiangruizj@163.com. LA - eng GR - 2025QNXM028/Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau)/ GR - W0125/Program for Youth Innovation in Future Medicine, Chongqing Medical University/ PT - Journal Article DEP - 20250816 PL - England TA - BMC Gastroenterol JT - BMC gastroenterology JID - 100968547 SB - IM MH - Humans MH - *Nomograms MH - Retrospective Studies MH - *Malnutrition/etiology/epidemiology/diagnosis MH - *Anorectal Malformations/surgery MH - Female MH - Pilot Projects MH - Logistic Models MH - *Postoperative Complications/etiology/epidemiology/diagnosis MH - Male MH - Infant MH - Risk Factors MH - ROC Curve MH - Prediction Algorithms PMC - PMC12357407 OTO - NOTNLM OT - Complex anorectal malformation OT - Lasso-Logistic regression OT - Nomogram model OT - Undernutrition COIS- Declarations. Ethics approval and consent to participate: This study was approved by the ethics committee of the Children's Hospital of Chongqing Medical University (Date: 2023/No: 01). All procedures in the study were carried out in accordance with national ethical guidelines for medical and health research involving human subjects, as well as the 1964 Helsinki Declaration and its subsequent amendments. Because of the retrospective nature of the study, the need for informed consent to participate was specifically waived by the Institutional Research Ethics Board of Children's Hospital affiliated Chongqing Medical University. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/08/17 00:27 MHDA- 2026/06/27 00:51 PMCR- 2025/08/16 CRDT- 2025/08/16 23:20 PHST- 2025/05/11 00:00 [received] PHST- 2025/07/28 00:00 [accepted] PHST- 2026/06/27 00:51 [medline] PHST- 2025/08/17 00:27 [pubmed] PHST- 2025/08/16 23:20 [entrez] PHST- 2025/08/16 00:00 [pmc-release] AID - 10.1186/s12876-025-04202-5 [pii] AID - 4202 [pii] AID - 10.1186/s12876-025-04202-5 [doi] PST - epublish SO - BMC Gastroenterol. 2025 Aug 16;25(1):588. doi: 10.1186/s12876-025-04202-5. PMID- 40813951 OWN - NLM STAT- MEDLINE DCOM- 20250826 LR - 20250826 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 30 IP - 1 DP - 2025 Aug 14 TI - Children's eating attitudes test (ChEAT): reliability and validation in German children and adolescents based on clinical data. PG - 64 LID - 10.1007/s40519-025-01773-w [doi] LID - 64 AB - PURPOSE: The objective of this study is to assess the validity of the German version of the Children's Eating Attitudes Test (ChEAT), an internationally used tool for the detection of eating disorder (ED) symptoms, in a clinical sample. METHODS: The ChEAT self-report questionnaire, comprising 26 items, was employed to examine eating behaviors of a clinical sample of 342 adolescents (aged 12-18 years) undergoing inpatient treatment at a child and adolescent psychiatric clinic in Germany. The ChEAT was validated through an exploratory factor analysis (EFA), followed by a confirmatory factor analysis (CFA) and an examination of internal consistency. Subsequent analyses were conducted to identify differences associated with participant characteristics, including age, gender, body mass index (BMI), and diagnosis. Furthermore, additional eating behaviors, depression, and anxiety symptoms were documented via supplementary questionnaires and correlated to the ChEAT to evaluate the convergent and discriminant validity. RESULTS: The factorial validity of the ChEAT was confirmed through EFA and CFA, resulting in a five-factor structure with the following dimensions: 'Body and Weight Concern,' 'Dieting,' 'Social Pressure,' 'Purging and Binge Eating,' and 'Food Preoccupation'. The 24-item model showed high internal consistency and demonstrated an acceptable fit to the data. Convergent and discriminant validity of the ChEAT was supported by significant correlations with other self-report questionnaires. Higher ChEAT average scores were observed in females and those with a history of eating or depressive disorders, whereas age or BMI showed no correlation. CONCLUSION: The data demonstrate that the German version of the ChEAT appears to be a reliable and valid instrument for identifying ED symptoms in clinical samples. However, further studies are necessary to evaluate the factor structure and validity. LEVEL OF EVIDENCE: V, cross-sectional, descriptive study. CI - (c) 2025. The Author(s). FAU - Nonnast, Lena AU - Nonnast L AD - LWL University Hospital Hamm for Child and Adolescent Psychiatry, Psychotherapy and Psychosomatic, Ruhr-University Bochum, Hamm, Germany. FAU - Derks, Laura Maria AU - Derks LM AUID- ORCID: 0000-0001-5333-0618 AD - LWL University Hospital Hamm for Child and Adolescent Psychiatry, Psychotherapy and Psychosomatic, Ruhr-University Bochum, Hamm, Germany. FAU - Deux, Natalie AU - Deux N AD - LWL University Hospital Hamm for Child and Adolescent Psychiatry, Psychotherapy and Psychosomatic, Ruhr-University Bochum, Hamm, Germany. FAU - Holtmann, Martin AU - Holtmann M AUID- ORCID: 0000-0003-2644-6601 AD - LWL University Hospital Hamm for Child and Adolescent Psychiatry, Psychotherapy and Psychosomatic, Ruhr-University Bochum, Hamm, Germany. FAU - Legenbauer, Tanja AU - Legenbauer T AUID- ORCID: 0000-0002-1580-9991 AD - LWL University Hospital Hamm for Child and Adolescent Psychiatry, Psychotherapy and Psychosomatic, Ruhr-University Bochum, Hamm, Germany. tanja.legenbauer@lwl.org. LA - eng GR - BMBF 01GI1329/Bundesministerium fur Bildung und Forschung/ PT - Journal Article PT - Validation Study DEP - 20250814 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - Adolescent MH - Child MH - Female MH - Male MH - Reproducibility of Results MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Germany MH - Surveys and Questionnaires MH - Psychometrics MH - *Feeding Behavior/psychology MH - Factor Analysis, Statistical MH - Self Report MH - Body Mass Index PMC - PMC12354608 OTO - NOTNLM OT - ChEAT OT - Children's eating attitudes test OT - Eating disorders OT - German children and adolescents OT - Psychometric characteristics COIS- Declarations. Ethics approval and consent to participate: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the local ethics committee of the LWL-University Hospital Hamm (Ruhr University Bochum no. 4854-13). Informed consent: Written consent for participation was obtained from patients and their legal guardians for participating in the study and for the use of their data for scientific purposes. Competing interests: Martin Holtmann served in an advisory role for Shire, Takeda and Medice and received conference attendance support or was paid for public speaking by Medice and Takeda. He received research support from the German Research Foundation and the German Ministry of Education and Research. He received royalties as Editor-in-Chief of the German Journal for Child and Adolescent Psychiatry and for textbooks from Hogrefe. The other authors declare no competing interests. EDAT- 2025/08/15 10:57 MHDA- 2025/08/31 20:08 PMCR- 2025/08/14 CRDT- 2025/08/15 00:34 PHST- 2025/03/25 00:00 [received] PHST- 2025/07/23 00:00 [accepted] PHST- 2025/08/31 20:08 [medline] PHST- 2025/08/15 10:57 [pubmed] PHST- 2025/08/15 00:34 [entrez] PHST- 2025/08/14 00:00 [pmc-release] AID - 10.1007/s40519-025-01773-w [pii] AID - 1773 [pii] AID - 10.1007/s40519-025-01773-w [doi] PST - epublish SO - Eat Weight Disord. 2025 Aug 14;30(1):64. doi: 10.1007/s40519-025-01773-w. PMID- 40812446 OWN - NLM STAT- MEDLINE DCOM- 20251101 LR - 20260520 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 216 DP - 2026 Jan 1 TI - Predictors of ultra-processed foods consumption in 4-year-old Spanish children. PG - 108268 LID - S0195-6663(25)00421-0 [pii] LID - 10.1016/j.appet.2025.108268 [doi] AB - Ultra-processed foods (UPF) consumption has increased in recent decades, contributing to poor diet quality and certain health problems in early childhood. This study aimed to evaluate UPF consumption in 4-year-old children and determine maternal and child sociodemographic and lifestyle predictors of UPF consumption. We analysed data for 1736 mother-child pairs from the INfancia y Medio Ambiente birth cohort study. Children's diets were parent-reported using validated food frequency questionnaires from which UPF consumption was calculated according to the NOVA classification. We used multinomial logistic regression to assess associations between sociodemographic and lifestyle characteristics and child UPF consumption in tertiles (low, intermediate, high). The mean (SD) daily UPF consumption was 414.6 (240.2)g/day, accounting for 32.8 % of the total daily intake. The main sources of UPF consumption were ultra-processed dairy products (44.3 %), ultra-processed beverages (17.8 %) and sweet foods (16.5 %). A higher maternal UPF consumption during pregnancy [RRR(medium) = 1.68 (95 %CI 1.23-2.30) and RRR(high) = 2.86 (95 %CI: 2.02-4.04)] and child television viewing [RRR(>1.5 h/day) = 1.65 (95 %CI: 1.21-2.25)] were positively associated with a higher child UPF consumption, whereas maternal age>/=30 years was associated with reduced UPF consumption [RRR = 0.71 (95 %CI: 0.54-0.94)]. These associations remained similar when stratified by sex, although maternal age effect was not significant in sex-specific models. Medium and high UPF consumption of mothers during pregnancy, younger age at pregnancy, and more television viewing in children were associated with higher UPF consumption at age 4. The identification of factors associated with child UPF consumption could support the development of health promotion strategies aimed at reducing UPF consumption in children. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Compan-Gabucio, Laura-Maria AU - Compan-Gabucio LM AD - Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, 28029, Madrid, Spain; Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), 03010, Alicante, Spain; Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), 03550, Alicante, Spain; Department of Surgery and Pathology, Miguel Hernandez University, 03550, Alicante, Spain. FAU - Torres-Collado, Laura AU - Torres-Collado L AD - Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, 28029, Madrid, Spain; Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), 03010, Alicante, Spain; Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), 03550, Alicante, Spain. FAU - Oncina-Canovas, Alejandro AU - Oncina-Canovas A AD - Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, 28029, Madrid, Spain; Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), 03010, Alicante, Spain; Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), 03550, Alicante, Spain. FAU - Fernandez-Tardon, Guillermo AU - Fernandez-Tardon G AD - Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, 28029, Madrid, Spain; Health Research Institute of Asturias (ISPA), 33011, Oviedo, Spain; University of Oviedo, 33003, Oviedo, Spain. FAU - Tardon, Adonina AU - Tardon A AD - Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, 28029, Madrid, Spain; Health Research Institute of Asturias (ISPA), 33011, Oviedo, Spain; University of Oviedo, 33003, Oviedo, Spain. FAU - Santa-Marina Rodriguez, Loreto AU - Santa-Marina Rodriguez L AD - Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, 28029, Madrid, Spain. FAU - Barroeta, Ziortza AU - Barroeta Z AD - Department of Preventive Medicine and Public Health, University of the Basque Country UPV/EHU, 48940, Biscay, Spain. FAU - Vrijheid, Martine AU - Vrijheid M AD - Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, 28029, Madrid, Spain; ISGlobal, 08036, Barcelona, Spain; Universitat Pompeu Fabra (UPF), 08005, Barcelona, Spain. FAU - Warkentin, Sarah AU - Warkentin S AD - Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, 28029, Madrid, Spain; ISGlobal, 08036, Barcelona, Spain; Universitat Pompeu Fabra (UPF), 08005, Barcelona, Spain. FAU - Llop, Sabrina AU - Llop S AD - Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, 28029, Madrid, Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO, 46020, Valencia, Spain; Universitat Jaume I-Universitat de Valencia, 46020, Valencia, Spain. FAU - Soler-Blasco, Raquel AU - Soler-Blasco R AD - Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, 28029, Madrid, Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO, 46020, Valencia, Spain; Universitat Jaume I-Universitat de Valencia, 46020, Valencia, Spain. FAU - Ojeda-Belokon, Carolina AU - Ojeda-Belokon C AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), 03010, Alicante, Spain; Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), 03550, Alicante, Spain. FAU - Garcia-de-la-Hera, Manuela AU - Garcia-de-la-Hera M AD - Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, 28029, Madrid, Spain; Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), 03010, Alicante, Spain; Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), 03550, Alicante, Spain. FAU - Vioque, Jesus AU - Vioque J AD - Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, 28029, Madrid, Spain; Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), 03010, Alicante, Spain; Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), 03550, Alicante, Spain. Electronic address: vioque@umh.es. FAU - Gonzalez-Palacios, Sandra AU - Gonzalez-Palacios S AD - Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, 28029, Madrid, Spain; Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), 03010, Alicante, Spain; Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), 03550, Alicante, Spain. LA - eng PT - Journal Article DEP - 20250812 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Child, Preschool MH - Female MH - *Fast Foods/statistics & numerical data MH - Male MH - Spain MH - *Diet/statistics & numerical data MH - Adult MH - Life Style MH - *Feeding Behavior MH - Mothers MH - Pregnancy MH - Cohort Studies MH - Television MH - Food, Processed OTO - NOTNLM OT - Associated factors OT - Cohort OT - Determinants OT - Infancy OT - Mother OT - NOVA OT - Sex-specific COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/08/14 22:51 MHDA- 2025/11/02 00:33 CRDT- 2025/08/14 19:41 PHST- 2025/05/30 00:00 [received] PHST- 2025/08/11 00:00 [revised] PHST- 2025/08/12 00:00 [accepted] PHST- 2025/11/02 00:33 [medline] PHST- 2025/08/14 22:51 [pubmed] PHST- 2025/08/14 19:41 [entrez] AID - S0195-6663(25)00421-0 [pii] AID - 10.1016/j.appet.2025.108268 [doi] PST - ppublish SO - Appetite. 2026 Jan 1;216:108268. doi: 10.1016/j.appet.2025.108268. Epub 2025 Aug 12. PMID- 40809750 OWN - NLM STAT- MEDLINE DCOM- 20250826 LR - 20251110 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Virtual post-COVID-19 clinics in Saudi Arabia: navigating the effect of the pandemic with a national project. PG - 1460324 LID - 10.3389/fpubh.2025.1460324 [doi] LID - 1460324 AB - BACKGROUND: During the COVID-19 pandemic, digital health transformation in healthcare services has undergone significant changes, especially in Saudi Arabia (SA), which was one of the first countries not only to battle the COVID-19 pandemic but also extended to post-COVID-19 conditions (PCCs) through a national project to provide a virtual assessment to COVID-19 patients at least 4 weeks after infection. Therefore, we conducted this study from 16 February to 16 June 2022 in SA to determine the frequency of PCCs, provide the necessary care, and identify the risk factors that delayed their return to their pre-COVID-19 health status. METHODS: A national project targeted all the registered 12,125 COVID-19 patients in the national register system by family physicians in the PCCs virtual clinics in the Medical Consultation Call Centre (937), using a validated assessment tool. RESULTS: A total of 12,125 recovered COVID-19 patients were called and asked to complete a virtual assessment; 5,451 (45.1%) did not answer, and 5,913 (48.8%) agreed and finished the test; 4,973, or 84.2% of participants, did not report any PCCs. The most frequent PCCs were fatigue (201, 3.4%), coughing (246, 4.2%), dyspnea (209, 3.6%), loss of appetite or weight loss (43, 7.3%), and poor concentration (50, 8.4%). All they needed was assurance and information about health. A mere 384 (6.5%) needed to be referred to PHCCs. A number of factors were associated with the need for a referral, and the severity of the SARS-CoV-2 infection, age group, sex, vaccination status, and body mass index were significant predictors of returning to the pre-infection health status. CONCLUSION: In SA, the response rate to the virtual post-COVID-19 clinics was low, and no-show was the main limitation. PCCs are a prevalent condition that requires further investigation. Many factors can predict the return of participants' pre-COVID-19 health status and participants' referral to post-COVID-19 clinics. CI - Copyright (c) 2025 Alenezi, Alsagheir, Amer, Alzubaidi, Alhomod and Alamaa. FAU - Alenezi, Faisal AU - Alenezi F AD - Deputy Minister Assistant for Hospitals, Services, Ministry of Health, Riyadh, Saudi Arabia. FAU - Alsagheir, Aeshah AU - Alsagheir A AD - Family and Home Health Care Consultant, Assistant Agency for Hospitals Services, Ministry of Health, Riyadh, Saudi Arabia. FAU - Amer, Samar AU - Amer S AD - Department of Public Health and Community Medicine, Zagazig University, Zagazig, Egypt. AD - Assistant Agency of Public Health, Ministry of Health, Riyadh, Saudi Arabia. FAU - Alzubaidi, Lamyia AU - Alzubaidi L AD - Consultant Diabetologist, Director of Technical Affairs and Ada'a in the Deputy for Hospitals Services, Ministry of Health, Riyadh, Saudi Arabia. FAU - Alhomod, Abdul-Aziz S AU - Alhomod AS AD - Department of Emergency Medicine, King Fahad City, Riyadh, Saudi Arabia. AD - Innovation and Regulatory Sandbox, Seha Virtual Hospital, Riyadh, Saudi Arabia. FAU - Alamaa, Tareef AU - Alamaa T AD - Deputy Minister of Curative Services, Ministry of Health, Riyadh, Saudi Arabia. LA - eng PT - Journal Article DEP - 20250730 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM EIN - Front Public Health. 2025 Oct 23;13:1709022. doi: 10.3389/fpubh.2025.1709022. PMID: 41211389 MH - Humans MH - Saudi Arabia/epidemiology MH - *COVID-19/epidemiology/therapy MH - Male MH - Female MH - Adult MH - Middle Aged MH - *Telemedicine MH - SARS-CoV-2 MH - Aged MH - Pandemics MH - Adolescent MH - Young Adult PMC - PMC12343649 OTO - NOTNLM OT - COVID-19 OT - SARS-CoV-2 OT - Saudi Arabia OT - assessment OT - digital transformation OT - medical appointments OT - post-COVID-19 conditions OT - virtual clinics COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/08/14 12:24 MHDA- 2025/08/31 20:07 PMCR- 2025/07/30 CRDT- 2025/08/14 05:27 PHST- 2024/07/05 00:00 [received] PHST- 2025/06/30 00:00 [accepted] PHST- 2025/08/31 20:07 [medline] PHST- 2025/08/14 12:24 [pubmed] PHST- 2025/08/14 05:27 [entrez] PHST- 2025/07/30 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1460324 [doi] PST - epublish SO - Front Public Health. 2025 Jul 30;13:1460324. doi: 10.3389/fpubh.2025.1460324. eCollection 2025. PMID- 40809311 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250816 IS - 1179-1594 (Print) IS - 1179-1594 (Electronic) IS - 1179-1594 (Linking) VI - 18 DP - 2025 TI - Accuracy of Caregiver-Reported Height, Weight, and BMI in a Pediatric Growth Clinic. PG - 2591-2600 LID - 10.2147/RMHP.S529963 [doi] AB - OBJECTIVE: To evaluate the accuracy of caregiver-reported height, weight, and body mass index (BMI) in children attending a pediatric growth clinic, and to explore the impact of these errors on clinical management and telemedicine. METHODS: This cross-sectional study included 132 children aged 6-12 years attending a pediatric growth clinic. Caregivers reported their children's height and weight, and standard measurements were taken within one week. BMI was calculated for both sets of data. Differences between caregiver-reported and standard measurements were analyzed across gender and age. Bland-Altman and linear regression analyses assessed agreement and correlation. RESULTS: Caregivers slightly overestimated height (+0.6 cm) and underestimated weight (-0.9 kg), resulting in an underestimation of BMI (-0.6 kg/m(2), p < 0.001). About 4.5% of overweight children were misclassified as non-overweight. Measurement errors showed no significant differences by gender or age group. Most caregivers measured their children's height and weight approximately once per month, regardless of subgroup. Despite minor discrepancies, caregiver-reported and standard data were strongly correlated (R(2) > 0.9). Bland-Altman analysis revealed good agreement, though height had slightly lower concordance. CONCLUSION: While caregiver-reported measurements exhibited minor errors, the magnitude was comparable to previous findings in general pediatric populations. Thus, caregiver-reported data may be suitable for follow-up monitoring in pediatric growth clinics but should be used cautiously for initial diagnosis or therapeutic decisions. CI - (c) 2025 Zhang and Wan. FAU - Zhang, Qian AU - Zhang Q AUID- ORCID: 0000-0001-5101-7353 AD - Department of Pediatrics, Beijing Jishuitan Hospital, Capital Medical University, Beijing, People's Republic of China. FAU - Wan, Nai-Jun AU - Wan NJ AUID- ORCID: 0000-0001-6128-8763 AD - Department of Pediatrics, Beijing Jishuitan Hospital, Capital Medical University, Beijing, People's Republic of China. LA - eng PT - Journal Article DEP - 20250808 PL - England TA - Risk Manag Healthc Policy JT - Risk management and healthcare policy JID - 101566264 PMC - PMC12343336 OTO - NOTNLM OT - caregiver-reported OT - measurement error OT - pediatric growth clinic OT - telemedicine COIS- The authors declare that they have no competing interests in this work. EDAT- 2025/08/14 06:28 MHDA- 2025/08/14 06:29 PMCR- 2025/08/08 CRDT- 2025/08/14 05:22 PHST- 2025/04/24 00:00 [received] PHST- 2025/07/28 00:00 [accepted] PHST- 2025/08/14 06:29 [medline] PHST- 2025/08/14 06:28 [pubmed] PHST- 2025/08/14 05:22 [entrez] PHST- 2025/08/08 00:00 [pmc-release] AID - 529963 [pii] AID - 10.2147/RMHP.S529963 [doi] PST - epublish SO - Risk Manag Healthc Policy. 2025 Aug 8;18:2591-2600. doi: 10.2147/RMHP.S529963. eCollection 2025. PMID- 40808608 OWN - NLM STAT- MEDLINE DCOM- 20260105 LR - 20261015 IS - 1468-4233 (Electronic) IS - 0301-0066 (Linking) VI - 55 IP - 1 DP - 2026 Jan TI - The relationship between visual motion detect thresholds and visual sensitivity to medial/lateral balance control. PG - 29-46 LID - 10.1177/03010066251365045 [doi] AB - The ability to differentiate between self-motion and motion in the environment is important for maintaining upright balance control. Visual motion can elicit the sensation of a fall by cueing false position sense. This study explores the relationship between thresholds for visual motion detection (VMDTs) and visual sensitivity to balance disturbances while walking. Thirty young adults (18-35 years) and 30 older adults (55-79 years) participated in a counter-balanced study where they: (1) walked on a self-paced treadmill within a virtual environment that delivered frontal plane multi-sine visual disturbances at three amplitudes (6 degrees , 10 degrees , and 15 degrees ), and (2) performed 100 trials of a two-alternative forced choice (2AFC) task, discriminating between a counterclockwise ("left") and clockwise ("right") rotation of a visual scene under three conditions (standing, standing with optic flow, and walking). Visual sensitivity was measured using frequency response functions of the center of mass displacement relative to the screen tilt (cm/deg). VMDTs were measured by fitting a psychometric curve to the 2AFC task responses. Significant positive correlations between measures of visual sensitivity and VMDTs were found for seven of nine conditions in young adults, with nonsignificant positive correlations in older adults. VMDTs were higher in older adults, though not significantly in the standing condition, indicating more motion in the environment is required for older adults to consciously perceive it. The positive correlations suggest that individuals with lower motion detection thresholds more accurately differentiate between self-motion and motion in the environment, resulting in lower responses to visual disturbances. FAU - DiBianca, Stephen J AU - DiBianca SJ AUID- ORCID: 0009-0005-1197-2432 AD - University of Delaware, Kinesiology and Applied Physiology, Newark, DE, USA. RINGGOLD: 5972 FAU - Reimann, Hendrik AU - Reimann H AD - University of Delaware, Kinesiology and Applied Physiology, Newark, DE, USA. RINGGOLD: 5972 FAU - Gray, Julia AU - Gray J AD - University of Delaware, Kinesiology and Applied Physiology, Newark, DE, USA. RINGGOLD: 5972 FAU - Peterka, Robert J AU - Peterka RJ AD - Oregon Health & Science University, Department of Neurology, Portland, OR, USA. FAU - Jeka, John J AU - Jeka JJ AD - University of Delaware, Kinesiology and Applied Physiology, Newark, DE, USA. RINGGOLD: 5972 LA - eng GR - I50 RX002361/RX/RRD VA/United States PT - Journal Article DEP - 20250814 PL - United States TA - Perception JT - Perception JID - 0372307 SB - IM MH - Humans MH - *Motion Perception/physiology MH - Middle Aged MH - Male MH - Adult MH - Female MH - Young Adult MH - *Postural Balance/physiology MH - Aged MH - *Sensory Thresholds/physiology MH - Adolescent MH - *Walking/physiology OTO - NOTNLM OT - older adults OT - psychophysics OT - thresholds OT - vision OT - visual motion sensitivity OT - walking balance control COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/08/14 06:28 MHDA- 2026/01/05 12:48 CRDT- 2025/08/14 04:23 PHST- 2026/01/05 12:48 [medline] PHST- 2025/08/14 06:28 [pubmed] PHST- 2025/08/14 04:23 [entrez] AID - 10.1177/03010066251365045 [doi] PST - ppublish SO - Perception. 2026 Jan;55(1):29-46. doi: 10.1177/03010066251365045. Epub 2025 Aug 14. PMID- 40806157 OWN - NLM STAT- MEDLINE DCOM- 20250910 LR - 20250910 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 15 DP - 2025 Aug 7 TI - Beyond Metabolism: Psychiatric and Social Dimensions in Bariatric Surgery Candidates with a BMI >/= 50-A Prospective Cohort Study. LID - 10.3390/nu17152573 [doi] LID - 2573 AB - Background: Super morbid obesity (SMO), defined as a body mass index (BMI) >/= 50 kg/m(2), represents a distinct and increasingly prevalent subgroup of patients undergoing bariatric surgery. Compared to individuals with lower BMI, patients with BMI >/= 50 kg/m(2) often exhibit unique clinical, psychological, and social characteristics that may influence treatment outcomes. Objective: This study aimed to compare demographic, metabolic, and psychiatric profiles of patients with BMI >/= 50 kg/m(2) and non-super morbid obesity (NSMO; BMI < 50 kg/m(2)) who were evaluated prior to bariatric surgery. Methods: A total of 319 patients were recruited between December 2022 and December 2023 at a bariatric center in Gdansk, Poland. All participants underwent a comprehensive preoperative assessment, including laboratory testing, psychometric screening (BDI, PHQ-9), and psychiatric interviews. Patients were stratified into class IV obesity and NSMO groups for comparative analysis. Results: Patients with BMI >/= 50 kg/m(2) were significantly older and more likely to report a history of lifelong obesity, family history of obesity, and childhood trauma. They had higher rates of obesity-related health problems such as hypertension, obstructive sleep apnea, and chronic venous insufficiency, as well as worse liver function and lipid profiles. Although the overall psychiatric burden was high in both groups, patients with BMI >/= 50 kg/m(2) reported fewer prior diagnoses of depression and eating disorders, despite similar scores on screening tools. Conclusions: Patients with BMI >/= 50 kg/m(2) represent a clinically distinct population with elevated metabolic risk, complex psychosocial backgrounds, and possibly underrecognized psychiatric burden. These findings underscore the need for multidisciplinary preoperative assessment and individualized treatment strategies in this group of patients. FAU - Herstowska, Marta AU - Herstowska M AUID- ORCID: 0000-0002-0905-6233 AD - Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, 80-210 Gdansk, Poland. FAU - Mysliwiec, Karolina AU - Mysliwiec K AD - Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, 80-210 Gdansk, Poland. FAU - Bandura, Marta AU - Bandura M AD - Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, 80-210 Gdansk, Poland. FAU - Chrzanowski, Jedrzej AU - Chrzanowski J AUID- ORCID: 0000-0001-6204-8622 AD - Department of Biostatistics and Translational Medicine, Medical University of Lodz, 92-215 Lodz, Poland. FAU - Burzynski, Jacek AU - Burzynski J AD - Department of Biostatistics and Translational Medicine, Medical University of Lodz, 92-215 Lodz, Poland. FAU - Michalak, Arkadiusz AU - Michalak A AD - Department of Biostatistics and Translational Medicine, Medical University of Lodz, 92-215 Lodz, Poland. FAU - Lejk, Agnieszka AU - Lejk A AD - Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, 80-210 Gdansk, Poland. FAU - Karamon, Izabela AU - Karamon I AD - Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, 80-210 Gdansk, Poland. FAU - Fendler, Wojciech AU - Fendler W AD - Department of Biostatistics and Translational Medicine, Medical University of Lodz, 92-215 Lodz, Poland. FAU - Kaska, Lukasz AU - Kaska L AD - Hospital of the Ministry of the Interior and Administration, 80-104 Gdansk, Poland. LA - eng GR - Number 01-10025/0008283/01/156/156/0/2025/Statutory Activity of the Department of Pediatrics, Diabetology and Endocrinology of the Medical University of Gdansk/ PT - Comparative Study PT - Journal Article DEP - 20250807 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Prospective Studies MH - Humans MH - Male MH - Female MH - Adult MH - Middle Aged MH - Poland MH - *Obesity, Morbid/psychology/surgery MH - *Body Mass Index MH - *Bariatric Surgery/psychology MH - Psychometrics MH - *Psychosocial Functioning MH - *Symptom Burden PMC - PMC12348223 OTO - NOTNLM OT - bariatric surgery OT - obesity OT - psychiatric dimension COIS- The authors declare no conflicts of interest. EDAT- 2025/08/14 06:28 MHDA- 2025/08/31 20:07 PMCR- 2025/08/07 CRDT- 2025/08/14 01:11 PHST- 2025/07/15 00:00 [received] PHST- 2025/08/04 00:00 [revised] PHST- 2025/08/06 00:00 [accepted] PHST- 2025/08/31 20:07 [medline] PHST- 2025/08/14 06:28 [pubmed] PHST- 2025/08/14 01:11 [entrez] PHST- 2025/08/07 00:00 [pmc-release] AID - nu17152573 [pii] AID - nutrients-17-02573 [pii] AID - 10.3390/nu17152573 [doi] PST - epublish SO - Nutrients. 2025 Aug 7;17(15):2573. doi: 10.3390/nu17152573. PMID- 40806098 OWN - NLM STAT- MEDLINE DCOM- 20250826 LR - 20250826 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 15 DP - 2025 Jul 31 TI - Psychometric Validation of a Standardized Instrument for Assessing Food and Nutrition Security Among College Students. LID - 10.3390/nu17152514 [doi] LID - 2514 AB - Background/Objective: Food insecurity refers to social or economic challenges that limit or create uncertainty around access to enough food. Among college students, food security status is usually determined with the USDA 10-item Food Security Survey Module, which has not been validated for this population. Nutrition security refers to consistent access to food and beverages that promote well-being, prevent disease, and emphasize equitable access to healthy, safe, and affordable foods. Currently, there is no standardized measure that assesses food and nutrition security tailored to the unique experiences of college students. This study aims to evaluate the validity and reliability of a newly developed College Student Food and Nutrition Security Survey Module (CS-FNSSM). Methods: A mixed-methods approach that combined an online survey with semi-structured cognitive interviews. Participants were students aged 18 and older from U.S. public universities. Quantitative data were analyzed using RStudio (version 4.4.1), and interview transcripts were thematically analyzed. Results: Survey responses were collected from 953 participants, including a subset of 69 participants for reliability testing and 30 participants for cognitive interviews. Rasch analysis showed good item performance and structural validity. The CS-FNSSM demonstrated strong sensitivity (89.09%), specificity (76.2%), moderate test-retest reliability (0.59), and good internal consistency (Cronbach's alpha = 0.79). Qualitative findings confirmed participant understanding of the items. Conclusions: The CS-FNSSM effectively identifies food and nutrition insecurity, with nutrition security emerging as a key issue. Addressing both is crucial for promoting the overall health and well-being of college students. FAU - Fiagbor, Rita AU - Fiagbor R AUID- ORCID: 0000-0003-0641-1874 AD - Department of Nutritional Science, Auburn University, 260 Lem Morrison, Auburn, AL 36849, USA. FAU - Brown, Onikia AU - Brown O AD - Department of Nutritional Science, Auburn University, 260 Lem Morrison, Auburn, AL 36849, USA. LA - eng GR - N/A/College of Human Sciences Hsieh Endowed Fund for Innovation and Research Excellence (Auburn University)./ PT - Journal Article PT - Validation Study DEP - 20250731 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Students/psychology/statistics & numerical data MH - Universities MH - Male MH - Female MH - Young Adult MH - *Psychometrics MH - Reproducibility of Results MH - Adolescent MH - *Food Security MH - Adult MH - Surveys and Questionnaires/standards MH - United States MH - *Food Insecurity MH - *Nutrition Surveys MH - Nutritional Status PMC - PMC12348516 OTO - NOTNLM OT - food security OT - nutrition security OT - reliability OT - survey OT - validation COIS- The authors declare no conflict of interest. EDAT- 2025/08/14 06:28 MHDA- 2025/08/31 20:07 PMCR- 2025/07/31 CRDT- 2025/08/14 01:11 PHST- 2025/06/24 00:00 [received] PHST- 2025/07/28 00:00 [revised] PHST- 2025/07/30 00:00 [accepted] PHST- 2025/08/31 20:07 [medline] PHST- 2025/08/14 06:28 [pubmed] PHST- 2025/08/14 01:11 [entrez] PHST- 2025/07/31 00:00 [pmc-release] AID - nu17152514 [pii] AID - nutrients-17-02514 [pii] AID - 10.3390/nu17152514 [doi] PST - epublish SO - Nutrients. 2025 Jul 31;17(15):2514. doi: 10.3390/nu17152514. PMID- 40806095 OWN - NLM STAT- MEDLINE DCOM- 20250826 LR - 20260127 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 15 DP - 2025 Jul 30 TI - How Accurate Is Multiple Imputation for Nutrient Intake Estimation? Insights from ASA24 Data. LID - 10.3390/nu17152510 [doi] LID - 2510 AB - Background/Objectives: Accurate dietary assessment is crucial for nutritional epidemiology, but tools like 24 h recalls (24HRs) face challenges with missing or implausible data. The Automated Self-Administered 24 h Dietary Assessment Tool (ASA24) facilitates large-scale data collection, but its lack of interviewer input may lead to implausible dietary recalls (IDRs), affecting data integrity. Multiple imputation (MI) is commonly used to handle missing data, but its effectiveness in high-variability dietary data is uncertain. This study aims to assess MI's accuracy in estimating nutrient intake under varying levels of missing data. Methods: Data from 24HRs completed by 743 adolescents (ages 13-18) in Ontario, Canada, were used. Implausible recalls were excluded based on nutrient thresholds, creating a cleaned reference dataset. Missing data were simulated at 10%, 20%, and 40% deletion rates. MI via chained equations was applied, incorporating demographic and psychosocial variables as predictors. Imputed values were compared to actual values using Spearman's correlation and accuracy within +/-10% of true values. Results: Spearman's rho values between the imputed and actual nutrient intakes were weak (mean rho approximately 0.24). Accuracy within +/-10% was low for most nutrients (typically < 25%), with no clear trend by missingness level. Diet quality scores showed slightly higher accuracy, but values were still under 30%. Conclusions: MI performed poorly in estimating individual nutrient intake in this adolescent sample. While MI may preserve sample characteristics, it is unreliable for accurate nutrient estimates and should be used cautiously. Future studies should focus on improving data quality and exploring better imputation methods. FAU - Woods, Nicolas AU - Woods N AUID- ORCID: 0000-0003-2248-3667 AD - School of Health Studies, Western University, London, ON N6A 3K7, Canada. AD - Human Environments Analysis Laboratory, Western University, London, ON N6A 3K7, Canada. AD - Children's Health Research Institute, London, ON N6C 2V5, Canada. FAU - Gilliland, Jason AU - Gilliland J AUID- ORCID: 0000-0002-2909-2178 AD - School of Health Studies, Western University, London, ON N6A 3K7, Canada. AD - Human Environments Analysis Laboratory, Western University, London, ON N6A 3K7, Canada. AD - Children's Health Research Institute, London, ON N6C 2V5, Canada. AD - Department of Geography and Environment, Western University, London, ON N6A 5C2, Canada. AD - Department of Epidemiology and Biostatistics, Western University, London, ON N6G 2M1, Canada. AD - Department of Paediatrics, Western University, London, ON N6A 5W9, Canada. AD - Lawson Research Institute, London, ON N6A 4V2, Canada. AD - London Health Sciences Centre Research Institute, London, ON N6A 5W9, Canada. FAU - McEachern, Louise W AU - McEachern LW AUID- ORCID: 0000-0003-4448-7837 AD - Human Environments Analysis Laboratory, Western University, London, ON N6A 3K7, Canada. AD - Children's Health Research Institute, London, ON N6C 2V5, Canada. AD - Department of Geography and Environment, Western University, London, ON N6A 5C2, Canada. FAU - O'Connor, Colleen AU - O'Connor C AD - Lawson Research Institute, London, ON N6A 4V2, Canada. AD - Brescia School of Food and Nutritional Sciences, Western University, London, ON N6G 2V4, Canada. FAU - Stranges, Saverio AU - Stranges S AUID- ORCID: 0000-0001-5226-8373 AD - Department of Epidemiology and Biostatistics, Western University, London, ON N6G 2M1, Canada. AD - Department of Family Medicine, Western University, London, ON N6G 2M1, Canada. AD - Department of Medicine, Western University, London, ON N6A 5A5, Canada. AD - Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy. FAU - Doherty, Sean AU - Doherty S AD - Human Environments Analysis Laboratory, Western University, London, ON N6A 3K7, Canada. AD - Department of Geography and Environmental Studies, Wilfrid Laurier University, Waterloo, ON N2L 3C5, Canada. FAU - Seabrook, Jamie A AU - Seabrook JA AUID- ORCID: 0000-0003-4297-6450 AD - Human Environments Analysis Laboratory, Western University, London, ON N6A 3K7, Canada. AD - Children's Health Research Institute, London, ON N6C 2V5, Canada. AD - Department of Epidemiology and Biostatistics, Western University, London, ON N6G 2M1, Canada. AD - Department of Paediatrics, Western University, London, ON N6A 5W9, Canada. AD - Lawson Research Institute, London, ON N6A 4V2, Canada. AD - London Health Sciences Centre Research Institute, London, ON N6A 5W9, Canada. AD - Brescia School of Food and Nutritional Sciences, Western University, London, ON N6G 2V4, Canada. LA - eng GR - 399384/CAPMC/CIHR/Canada PT - Journal Article DEP - 20250730 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Nutrients) SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - *Nutrition Assessment MH - Ontario MH - *Diet Surveys/methods MH - *Diet Records MH - *Nutrients MH - *Diet MH - Mental Recall MH - Energy Intake MH - Reproducibility of Results MH - *Eating MH - Data Accuracy PMC - PMC12348990 OTO - NOTNLM OT - 24 h recalls OT - adolescent nutrition OT - data imputation accuracy OT - dietary assessment tools OT - implausible dietary recalls OT - missing data OT - multiple imputation OT - nutrient intake estimation OT - nutrient thresholds OT - nutritional epidemiology COIS- The authors declare no conflicts of interest. EDAT- 2025/08/14 06:27 MHDA- 2025/08/31 20:07 PMCR- 2025/07/30 CRDT- 2025/08/14 01:11 PHST- 2025/07/10 00:00 [received] PHST- 2025/07/27 00:00 [revised] PHST- 2025/07/29 00:00 [accepted] PHST- 2025/08/31 20:07 [medline] PHST- 2025/08/14 06:27 [pubmed] PHST- 2025/08/14 01:11 [entrez] PHST- 2025/07/30 00:00 [pmc-release] AID - nu17152510 [pii] AID - nutrients-17-02510 [pii] AID - 10.3390/nu17152510 [doi] PST - epublish SO - Nutrients. 2025 Jul 30;17(15):2510. doi: 10.3390/nu17152510. PMID- 40806042 OWN - NLM STAT- MEDLINE DCOM- 20250826 LR - 20250826 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 15 DP - 2025 Jul 28 TI - Validating the Arabic Adolescent Nutrition Literacy Scale (ANLS): A Reliable Tool for Measuring Nutrition Literacy. LID - 10.3390/nu17152457 [doi] LID - 2457 AB - Introduction: Nutrition literacy has garnered growing research attention worldwide, yet only a few instruments have been developed to specifically measure this construct among adolescents. Accordingly, the present research sought to examine the validity and reliability of the Adolescent Nutrition Literacy Scale (ANLS) within a group of Lebanese adolescents. Methods: A cross-sectional study was carried out from December 2022 to March 2023, targeting a nationally representative sample. Results: Fit indices of the three-factor structure were good. Internal reliability was adequate for the following three subscales: Functional Nutrition Literacy (FNL) (omega = 0.88/alpha = 0.88), Interactive Nutrition Literacy (INL) (omega = 0.87/alpha = 0.86) and Critical Nutrition Literacy (CNL) (omega = 0.89/alpha = 0.89). Invariance was established across genders at configural, metric, and scalar levels. A significantly higher mean FNL and INL scores were found in males compared to females, with no significant difference between the two genders in terms of CNL. Higher FNL, but not CNL and INL scores were significantly associated with lower child food security. Conclusions: The Arabic ANLS has exhibited robust psychometric reliability, validity, and cost-effectiveness as a tool for assessing nutrition literacy. By utilizing the Arabic version of the ANLS, we can more efficiently and accurately assess the nutritional literacy of adolescents. FAU - Obeid, Sahar AU - Obeid S AD - Social and Education Sciences Department, School of Arts and Sciences, Lebanese American University, Byblos P.O. Box 36, Lebanon. FAU - Hallit, Souheil AU - Hallit S AUID- ORCID: 0000-0001-6918-5689 AD - School of Medicine and Medical Sciences, Holy Spirit University of Kaslik, Jounieh P.O. Box 446, Lebanon. AD - Department of Psychology, College of Humanities, Effat University, Jeddah 21478, Saudi Arabia. AD - Applied Science Research Center, Applied Science Private University, Amman 11937, Jordan. FAU - Fekih-Romdhane, Feten AU - Fekih-Romdhane F AUID- ORCID: 0000-0002-2569-8017 AD - The Tunisian Center of Early Intervention in Psychosis, Department of Psychiatry "Ibn Omrane", Razi Hospital, Manouba 2010, Tunisia. AD - Faculty of Medicine of Tunis, Tunis El Manar University, Tunis 1007, Tunisia. FAU - Sacre, Yonna AU - Sacre Y AD - Department of Nutrition and Food Sciences, Faculty of Arts and Sciences, Holy Spirit University of Kaslik (USEK), Jounieh P.O. Box 446, Lebanon. FAU - Hokayem, Marie AU - Hokayem M AD - Department of Nutrition and Food Sciences, Faculty of Arts and Sciences, Holy Spirit University of Kaslik (USEK), Jounieh P.O. Box 446, Lebanon. FAU - Saeidi, Ayoub AU - Saeidi A AUID- ORCID: 0000-0003-2458-6256 AD - Department of Physical Education and Sport Sciences, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj 66177-15175, Iran. FAU - Sabbah, Lamya AU - Sabbah L AUID- ORCID: 0009-0003-8470-272X AD - Faculty of Arts and Sciences, Modern University for Business and Science (MUBS), Damour P.O. Box 113-7501, Lebanon. AD - Center of Excellence in Research, Education, and Cultural Studies (CEREC), Beirut, Lebanon. FAU - Tzenios, Nikolaos AU - Tzenios N AUID- ORCID: 0000-0002-6679-2296 AD - Faculty of Public Health, Charisma University, London EC1V 7QE, UK. FAU - Hoteit, Maha AU - Hoteit M AUID- ORCID: 0000-0001-7392-4835 AD - PHENOL Research Program, Faculty of Public Health, Section 1, Lebanese University, Beirut P.O. Box 6573, Lebanon. AD - Department of Primary Care and Population Health, University of Nicosia Medical School, Nicosia 2417, Cyprus. AD - INSPECT-LB (Institut National de Sante Publique, d'Epidemiologie Clinique et de Toxicologie-Liban), Beirut, Lebanon. LA - eng PT - Journal Article PT - Validation Study DEP - 20250728 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - *Health Literacy MH - Reproducibility of Results MH - Cross-Sectional Studies MH - Lebanon MH - Psychometrics MH - Surveys and Questionnaires MH - Nutritional Status MH - Child PMC - PMC12348767 OTO - NOTNLM OT - Arabic OT - adolescent OT - nutrition literacy OT - psychometric properties OT - scale COIS- The authors declare no conflicts of interest. EDAT- 2025/08/14 06:27 MHDA- 2025/08/31 20:07 PMCR- 2025/07/28 CRDT- 2025/08/14 01:10 PHST- 2025/06/28 00:00 [received] PHST- 2025/07/17 00:00 [revised] PHST- 2025/07/25 00:00 [accepted] PHST- 2025/08/31 20:07 [medline] PHST- 2025/08/14 06:27 [pubmed] PHST- 2025/08/14 01:10 [entrez] PHST- 2025/07/28 00:00 [pmc-release] AID - nu17152457 [pii] AID - nutrients-17-02457 [pii] AID - 10.3390/nu17152457 [doi] PST - epublish SO - Nutrients. 2025 Jul 28;17(15):2457. doi: 10.3390/nu17152457. PMID- 40806009 OWN - NLM STAT- MEDLINE DCOM- 20250826 LR - 20250826 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 15 DP - 2025 Jul 24 TI - Association of Breakfast Food Types with Dietary Knowledge, Attitudes, and Practices Among School-Aged Children. LID - 10.3390/nu17152424 [doi] LID - 2424 AB - Background: Skipping breakfast, a prevalent issue among children and adolescents, has been reported to be associated with academic performance and long-term health. However, less attention has been given to the types of breakfast foods consumed. Therefore, our study aims to investigate the association between breakfast variety and dietary knowledge, attitude, and practice (KAP) among preadolescents. Methods: The study included 1449 students in grades 4-6 from Zhongshan city, Guangdong province. Data were collected through face-to-face field investigation using a validated questionnaire. The questionnaire encompassed sociodemographic characteristics, as well as dietary KAP. Results: Among all participants, 1315 reported consuming breakfast daily. Dietary diversity varied significantly: 8.8% consumed only 1 type of food, 52.9% consumed 2-4 types, and 38.3% consumed >/=5 types. Students who consumed a greater variety of breakfast foods exhibited more favorable dietary and lifestyle patterns. Specifically, those who consumed >/=5 types of food showed statistically significant associations with healthier practices, including reduced intake of sugary beverages and night snacks, stronger adherence to dietary guidelines, more positive attitudes toward improving eating habits, longer sleep durations, increased participation in meal preparation, greater dish variety in meals, and higher engagement in daily physical activity. Conclusions: Breakfast variety was associated with KAP, particularly when breakfast types >/= 5, providing more sufficient and favorable evidence for breakfast consumption. FAU - Zhou, Siyao AU - Zhou S AD - Department of Nutrition, School of Medicine, Jinan University, Guangzhou 510632, China. FAU - Zhao, Hanqing AU - Zhao H AD - Department of Nutrition, School of Medicine, Jinan University, Guangzhou 510632, China. FAU - Xiao, Yu AU - Xiao Y AUID- ORCID: 0009-0004-4514-3870 AD - Department of Nutrition, School of Medicine, Jinan University, Guangzhou 510632, China. FAU - Li, Jie AU - Li J AD - Department of Nutrition, School of Medicine, Jinan University, Guangzhou 510632, China. FAU - Huang, Qiaoli AU - Huang Q AD - Department of Nutrition, School of Medicine, Jinan University, Guangzhou 510632, China. FAU - Zhang, Yufang AU - Zhang Y AD - Department of Nutrition, School of Medicine, Jinan University, Guangzhou 510632, China. FAU - Guo, Fengfeng AU - Guo F AD - Department of Nutrition, School of Medicine, Jinan University, Guangzhou 510632, China. FAU - Xu, Beibei AU - Xu B AD - Department of Nutrition, School of Medicine, Jinan University, Guangzhou 510632, China. FAU - Zou, Haoyan AU - Zou H AD - Department of Nutrition, School of Medicine, Jinan University, Guangzhou 510632, China. FAU - Huang, Xiaoxia AU - Huang X AD - Health Care Centre for Primary and Secondary School of Zhongshan, Zhongshan 528403, China. FAU - Huang, Sizhe AU - Huang S AD - Health Care Centre for Primary and Secondary School of Zhongshan, Zhongshan 528403, China. FAU - Wang, Lijun AU - Wang L AD - Department of Nutrition, School of Medicine, Jinan University, Guangzhou 510632, China. LA - eng GR - CNS-YUM2024-121/Scientific Research Fund of China Nutrition Society/ GR - 2023A1515030168/Guangdong Basic and Applied Basic Research Foundation/ GR - YDXS2410/"Master Mentor Plan" of Jinan University, Nutrition Professional Instructor Comprehensive Competency Enhancement Practical Program/ PT - Journal Article DEP - 20250724 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Breakfast MH - Female MH - Male MH - Child MH - *Health Knowledge, Attitudes, Practice MH - *Feeding Behavior MH - *Diet MH - *Students/psychology MH - Surveys and Questionnaires MH - China MH - Cross-Sectional Studies MH - Diet, Healthy PMC - PMC12348111 OTO - NOTNLM OT - breakfast OT - children OT - eating behavior OT - food preferences COIS- The authors declare no conflicts of interest related to this work. EDAT- 2025/08/14 06:28 MHDA- 2025/08/31 20:07 PMCR- 2025/07/24 CRDT- 2025/08/14 01:10 PHST- 2025/06/07 00:00 [received] PHST- 2025/07/09 00:00 [revised] PHST- 2025/07/23 00:00 [accepted] PHST- 2025/08/31 20:07 [medline] PHST- 2025/08/14 06:28 [pubmed] PHST- 2025/08/14 01:10 [entrez] PHST- 2025/07/24 00:00 [pmc-release] AID - nu17152424 [pii] AID - nutrients-17-02424 [pii] AID - 10.3390/nu17152424 [doi] PST - epublish SO - Nutrients. 2025 Jul 24;17(15):2424. doi: 10.3390/nu17152424. PMID- 40804944 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250817 IS - 2075-4418 (Print) IS - 2075-4418 (Electronic) IS - 2075-4418 (Linking) VI - 15 IP - 15 DP - 2025 Aug 7 TI - Factors Affecting Thyroid Volume in Children Aged 4 to 18 Years. LID - 10.3390/diagnostics15151980 [doi] LID - 1980 AB - BACKGROUND AND OBJECTIVES: Ultrasound measurement of thyroid volume is not routinely performed in children without suspected thyroid disorders. However, pediatricians must be aware of the normal thyroid volume values in children in order to recognize and treat thyroid disorders in children on time. Therefore, this study aimed to explore factors that influence thyroid volume in children aged 4 to 18 years and to provide descriptive data on thyroid volume across this age range. MATERIALS AND METHODS: This was a prospective, non-interventional cross-sectional study conducted on a population of children aged 4 to 18 years without confirmed thyroid disorders. We used validated formulas for calculating thyroid volume that integrate the linear dimensions of this organ, such as length, width, and depth, as well as the appropriate correction factor. The Spearman or Pearson correlation coefficient was calculated to assess the relationship between total thyroid volume and various continuous variables, while multiple linear regression analysis was used to evaluate the effect of potential predictors on the total thyroid volume. RESULTS: The study included 100 children, predominantly girls (75.0%). Significant positive correlations with thyroid volume were found for age, height, weight, body mass index (BMI), body surface area, serum creatinine, birthweight, and number of comorbidities, while calcitonin was negatively correlated with children's thyroid volume. We identified age, BMI, and serum creatinine as significant independent positive predictors of thyroid volume in children. CONCLUSIONS: Age, BMI, and serum creatinine emerged as significant independent positive predictors of thyroid volume and should be considered when interpreting pediatric thyroid ultrasound measurements. FAU - Folic, Nevena AU - Folic N AUID- ORCID: 0000-0001-9494-881X AD - Department of Pediatrics, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia. AD - Pediatric Clinic, University Clinical Center Kragujevac, 34000 Kragujevac, Serbia. FAU - Folic, Marko AU - Folic M AUID- ORCID: 0000-0002-0807-3488 AD - Center for Pharmaceutical and Pharmacological Research, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia. AD - Department of Clinical Pharmacology, University Clinical Center Kragujevac, 34000 Kragujevac, Serbia. FAU - Milosavljevic, Milos N AU - Milosavljevic MN AUID- ORCID: 0000-0002-1786-1507 AD - Department of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia. FAU - Pejcic, Ana V AU - Pejcic AV AUID- ORCID: 0000-0003-1741-0025 AD - Department of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia. FAU - Jankovic, Slobodan AU - Jankovic S AD - Department of Clinical Pharmacology, University Clinical Center Kragujevac, 34000 Kragujevac, Serbia. AD - Department of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia. FAU - Vulovic, Maja AU - Vulovic M AD - Department of Anatomy, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia. FAU - Stepovic, Milos AU - Stepovic M AUID- ORCID: 0000-0002-6740-0215 AD - Department of Anatomy, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia. FAU - Mihajlovic, Isidora AU - Mihajlovic I AD - Department of Pediatrics, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia. AD - Pediatric Clinic, University Clinical Center Kragujevac, 34000 Kragujevac, Serbia. FAU - Milosavljevic, Jovana AU - Milosavljevic J AD - Department of Anatomy, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia. LA - eng GR - Junior Project No. 16/25/Faculty of Medical Sciences, University of Kragujevac/ PT - Journal Article DEP - 20250807 PL - Switzerland TA - Diagnostics (Basel) JT - Diagnostics (Basel, Switzerland) JID - 101658402 PMC - PMC12346054 OTO - NOTNLM OT - children OT - thyroid gland OT - thyroid volume OT - ultrasound COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declare no conflicts of interest. EDAT- 2025/08/14 06:27 MHDA- 2025/08/14 06:28 PMCR- 2025/08/07 CRDT- 2025/08/14 01:02 PHST- 2025/07/12 00:00 [received] PHST- 2025/08/04 00:00 [revised] PHST- 2025/08/06 00:00 [accepted] PHST- 2025/08/14 06:28 [medline] PHST- 2025/08/14 06:27 [pubmed] PHST- 2025/08/14 01:02 [entrez] PHST- 2025/08/07 00:00 [pmc-release] AID - diagnostics15151980 [pii] AID - diagnostics-15-01980 [pii] AID - 10.3390/diagnostics15151980 [doi] PST - epublish SO - Diagnostics (Basel). 2025 Aug 7;15(15):1980. doi: 10.3390/diagnostics15151980. PMID- 40803867 OWN - NLM STAT- MEDLINE DCOM- 20250827 LR - 20250827 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 9 IP - 1 DP - 2025 Aug 13 TI - Cross-cultural adaptation and validation of Neonatal Eating Assessment Tool (NeoEAT)-Paladai/cup feeding in Tamil: a caregiver-reported assessment tool. LID - 10.1136/bmjpo-2025-003403 [doi] LID - e003403 AB - BACKGROUND: Cup feeding is an alternative method to provide nutrition to infants exhibiting difficulties in breastfeeding. Paladai is a cup commonly used to feed milk to infants in several parts of India. Parental reports of infant feeding help address feeding concerns and establish successful oral feeding. METHOD: This cross-sectional study was conducted in a quaternary care hospital in South India. The NeoEAT-Paladai/cup in Tamil was developed through a systematic process of cross-cultural adaptation and included 64 items. A total of 325 Tamil-speaking mothers of children younger than 7 months who were fed through the paladai exclusively or partially, along with breastfeeding, completed the NeoEAT-Paladai (Tamil). RESULTS: Factor analysis of the responses yielded five subscales with high internal consistency reliability across subscales (alpha=0.858 to 0.908) and the full scale (alpha=0.963). Test-retest reliability was high for the full scale (intraclass correlation=0.995). Infants with feeding concerns demonstrated significantly higher total and subscale scores than infants without feeding concerns (p<0.001). CONCLUSION: The NeoEAT-Paladai (Tamil) allows clinicians and caregivers of Tamil-speaking populations to monitor the feeding behaviours of infants when being fed by paladai. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Jayapradha, Gopalakrishnan AU - Jayapradha G AUID- ORCID: 0009-0009-3839-589X AD - Sri Ramachandra Faculty of Audiology and Speech Language Pathology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India. FAU - Amboiram, Prakash AU - Amboiram P AUID- ORCID: 0000-0003-1487-836X AD - Neonatology, Sri Ramachandra University Medical College, Chennai, Tamil Nadu, India. FAU - Anand, Sanjanaa AU - Anand S AD - Sri Ramachandra Faculty of Audiology and Speech Language Pathology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India. FAU - Akula, Deekshitha AU - Akula D AD - Sri Ramachandra Faculty of Audiology and Speech Language Pathology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India. FAU - Pados, Britt Frisk AU - Pados BF AD - Neonatal nurse practitioner and International Board Certi fi ed Lactation Consultant, Wellesley, Massachusetts, USA. FAU - Venkatesh, Lakshmi AU - Venkatesh L AUID- ORCID: 0000-0002-1918-6998 AD - Sri Ramachandra Faculty of Audiology and Speech Language Pathology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India lakshmiv@sriramachandra.edu.in. LA - eng PT - Journal Article PT - Validation Study DEP - 20250813 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - India MH - Female MH - Cross-Sectional Studies MH - Infant MH - Male MH - *Breast Feeding MH - Reproducibility of Results MH - Infant, Newborn MH - Adult MH - Cross-Cultural Comparison MH - *Feeding Behavior MH - Surveys and Questionnaires MH - Mothers MH - Psychometrics PMC - PMC12352152 OTO - NOTNLM OT - Breastfeeding OT - Caregivers OT - Infant OT - Low and Middle Income Countries OT - Neonatology COIS- Competing interests: None declared. EDAT- 2025/08/14 00:27 MHDA- 2025/08/31 20:07 PMCR- 2025/08/13 CRDT- 2025/08/13 21:33 PHST- 2025/02/06 00:00 [received] PHST- 2025/07/14 00:00 [accepted] PHST- 2025/08/31 20:07 [medline] PHST- 2025/08/14 00:27 [pubmed] PHST- 2025/08/13 21:33 [entrez] PHST- 2025/08/13 00:00 [pmc-release] AID - 10.1136/bmjpo-2025-003403 [pii] AID - bmjpo-2025-003403 [pii] AID - 10.1136/bmjpo-2025-003403 [doi] PST - epublish SO - BMJ Paediatr Open. 2025 Aug 13;9(1):e003403. doi: 10.1136/bmjpo-2025-003403. PMID- 40803324 OWN - NLM STAT- MEDLINE DCOM- 20260211 LR - 20260825 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 1 DP - 2026 Mar TI - Precision and Sample Sizes Achieved for Infant and Young Child Feeding Indicators Evaluated in Anthropometry Assessments: A Secondary Analysis of Population-Representative Surveys in Refugee Settings. PG - e70078 LID - 10.1111/mcn.70078 [doi] LID - e70078 AB - This study characterizes the sample size and precision for infant and young child feeding (IYCF) indicators evaluated in surveys conducted in refugee settings, characterized by sample sizes enabling timely information to inform humanitarian response. We analyzed surveys provided by the United Nations High Commissioner for Refugees conducted from 2013 to 2019. For eight IYCF indicators recommended in the current global guidance, we assessed achieved sample sizes and precision by evaluating the half-width of 95% confidence intervals (HWCIs) by survey design. Among cluster surveys, we characterized the intraclass correlation coefficients (ICCs) and design effects. Final analysis included 203 surveys from refugee settings in 15 countries. Ever breastfed and bottle feeding indicators were the most precise (median HWCI: 3.1% and 3.6%) due to inclusion of all children 0-23 months resulting in relatively large sample sizes and estimates of prevalence close to 100% and 0%, respectively. Exclusive breastfeeding under 6 months and the introduction of solid foods (6-8 months) had the lowest precision (median HWCI estimates: 12.6% and 18.2%). In cluster surveys, early initiation of breastfeeding and flesh food consumption stood out with markedly higher design effects (median estimates: 2.63 and 2.17) driven by relatively larger sample sizes and high ICCs (median estimates: 0.31 and 0.27); all other indicators had median design effects < 1.3. Evidence on expected variation in precision and heterogeneity by indicator can help design surveys with samples that allow for the rapid collection of data sufficient to inform emergency responses. High caution is needed when interpreting estimates of exclusive breastfeeding and introduction of solid foods in past surveys given lower precision. CI - Published 2026. This article is a U.S. Government work and is in the public domain in the USA. Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Leidman, Eva AU - Leidman E AUID- ORCID: 0000-0002-4191-5931 AD - Center for Global Health, Centers for Disease Control and Prevention, Division of Global Health Protection, Atlanta, Georgia, USA. FAU - Kianian, Behzad AU - Kianian B AUID- ORCID: 0000-0002-5106-4157 AD - Center for Global Health, Centers for Disease Control and Prevention, Division of Global Health Protection, Atlanta, Georgia, USA. FAU - Bilukha, Oleg AU - Bilukha O AD - Center for Global Health, Centers for Disease Control and Prevention, Division of Global Health Protection, Atlanta, Georgia, USA. LA - eng PT - Journal Article DEP - 20250813 PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - Infant MH - *Breast Feeding/statistics & numerical data MH - *Refugees/statistics & numerical data MH - Sample Size MH - *Anthropometry/methods MH - Female MH - Infant, Newborn MH - *Infant Nutritional Physiological Phenomena MH - Bottle Feeding/statistics & numerical data MH - Male MH - Child, Preschool MH - *Nutrition Surveys MH - Surveys and Questionnaires PMC - PMC12893512 OTO - NOTNLM OT - anthropometry OT - breastfeeding OT - infant and young child feeding OT - refugee settings OT - surveys COIS- The authors declare no conflicts of interest. EDAT- 2025/08/14 00:27 MHDA- 2026/02/11 18:59 PMCR- 2025/08/13 CRDT- 2025/08/13 18:42 PHST- 2025/06/25 00:00 [revised] PHST- 2025/01/09 00:00 [received] PHST- 2025/07/09 00:00 [accepted] PHST- 2026/02/11 18:59 [medline] PHST- 2025/08/14 00:27 [pubmed] PHST- 2025/08/13 18:42 [entrez] PHST- 2025/08/13 00:00 [pmc-release] AID - MCN70078 [pii] AID - 10.1111/mcn.70078 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Mar;22(1):e70078. doi: 10.1111/mcn.70078. Epub 2025 Aug 13. PMID- 40802383 OWN - NLM STAT- MEDLINE DCOM- 20250827 LR - 20250827 IS - 2237-9622 (Electronic) IS - 1679-4974 (Print) IS - 1679-4974 (Linking) VI - 34 DP - 2025 TI - Adaptation of a pediatric hospital to the recommendations of the Brazilian Dietary Guidelines, Niteroi, 2023. PG - e20240532 LID - S2237-96222025000100256 [pii] LID - 10.1590/S2237-96222025v34e20240532.en [doi] LID - e20240532 AB - OBJECTIVE: To evaluate the adequacy of a pediatric hospital in a large city in the metropolitan region of Rio de Janeiro to the recommendations of the Brazilian Dietary Guidelines regarding the service provision contract, dietary prescription and aspects of the food environment. METHODS: Observational study evaluating four dimensions of the hospital food environment and its surroundings: current legislation and food service provision contract; prescribed diets, the menu and technical sheets of preparations; infrastructure of the Food and Nutrition Unit; and the sale and advertising of food in the internal and external food environment. Technical visits were conducted to evaluate documents, assess menus and conduct direct observation, using previously validated instruments. RESULTS: The service provision contract was fully compliant for the infant formulas and enteral diets, and the menu was partially compliant (81%). Most of the preparations analyzed were classified as high quality or intermediate quality (77%). Considering the infrastructure of the Food and Nutrition Unit, 90%, 89% and 71% of the responses were positive for essential, recommended and necessary items, respectively. The hospital's food environment stood out for offering in nature and minimally processed foods. However, there was a wide variety of ultra-processed foods available in self-service machines and from street vendors. CONCLUSION: Despite a satisfactory food environment, the presence and sale of ultra-processed foods was identified in the hospital and its surroundings. FAU - Costa, Amine Farias AU - Costa AF AUID- ORCID: 0000-0001-7944-7291 AD - Instituto Nacional de Cancer, Hospital do Cancer II, Rio de Janeiro, RJ, Brazil. FAU - Tavares, Leticia Ferreira AU - Tavares LF AUID- ORCID: 0000-0001-5205-2994 AD - Universidade Federal do Rio de Janeiro, Instituto de Nutricao Josue de Castro, Departamento de Gastronomia, Rio de Janeiro, RJ, Brazil. FAU - Castro Junior, Paulo Cesar Pereira de AU - Castro Junior PCP AUID- ORCID: 0000-0002-6629-9610 AD - Universidade Federal do Rio de Janeiro, Instituto de Nutricao Josue de Castro, Departamento de Nutricao Social Aplicada, Rio de Janeiro, RJ, Brazil. FAU - Barbosa, Raphael Barreto da Conceicao AU - Barbosa RBDC AUID- ORCID: 0000-0001-9838-9736 AD - Instituto Desiderata, Rio de Janeiro, RJ, Brazil. FAU - Honorio, Olivia Souza AU - Honorio OS AUID- ORCID: 0000-0003-4174-6987 AD - Instituto Desiderata, Rio de Janeiro, RJ, Brazil. FAU - Oliveira, Ana Carolina Rocha AU - Oliveira ACR AUID- ORCID: 0000-0001-8868-6593 AD - Instituto Desiderata, Rio de Janeiro, RJ, Brazil. FAU - Cardoso, Leticia de Oliveira AU - Cardoso LO AUID- ORCID: 0000-0003-1312-1808 AD - Fundacao Oswaldo Cruz, Escola Nacional de Saude Publica Sergio Arouca, Rio de Janeiro, RJ, Brazil. LA - eng LA - por PT - Journal Article PT - Observational Study DEP - 20250808 PL - Brazil TA - Epidemiol Serv Saude JT - Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil JID - 101248287 SB - IM MH - Brazil MH - Humans MH - *Nutrition Policy MH - *Hospitals, Pediatric/standards/organization & administration MH - *Food Service, Hospital/standards/organization & administration/legislation & jurisprudence MH - Infant MH - Infant Formula/standards MH - Guideline Adherence/statistics & numerical data PMC - PMC12342713 EDAT- 2025/08/13 12:30 MHDA- 2025/08/31 20:07 PMCR- 2025/08/08 CRDT- 2025/08/13 11:54 PHST- 2024/09/18 00:00 [received] PHST- 2025/03/09 00:00 [accepted] PHST- 2025/08/31 20:07 [medline] PHST- 2025/08/13 12:30 [pubmed] PHST- 2025/08/13 11:54 [entrez] PHST- 2025/08/08 00:00 [pmc-release] AID - S2237-96222025000100256 [pii] AID - 10.1590/S2237-96222025v34e20240532.en [doi] PST - epublish SO - Epidemiol Serv Saude. 2025 Aug 8;34:e20240532. doi: 10.1590/S2237-96222025v34e20240532.en. eCollection 2025. PMID- 40802314 OWN - NLM STAT- MEDLINE DCOM- 20250825 LR - 20250825 IS - 1678-4561 (Electronic) IS - 1413-8123 (Linking) VI - 30 IP - 7 DP - 2025 Jul TI - Performance of international growth references to assess nutritional status in a sample of adolescents from Northeastern Brazil. PG - e03122024 LID - S1413-81232025000700908 [pii] LID - 10.1590/1413-81232025307.03122024 [doi] AB - This study aimed to assess the obesity diagnostic accuracy based on body fat mass (FM) in a sample of adolescents from northeastern Brazil, and to compare their nutritional status classified by the height and body mass index (BMI) references from the World Health Organization (WHO/2007), Centers for Disease Control And Prevention (CDC/2000), International Obesity Task Force (IOTF/2012), Brazil (2006) and MULT (2023). We selected 256 adolescents (10-19y) from the city of Natal, Brazil. Their nutritional status was classified according to the growth references and the obesity classification and the diagnostic accuracy were performed according to their FM, obtained through the Dual-energy X-ray absorptiometry (DXA). The Bland-Altman method was used to verify the concordance among the growth references. The highest obesity prevalence (4.3%) was by applying WHO, CDC and Brazil and the highest critical difference (CD) was found between the BMI references of WHO and MULT (CD = 0.61). The MULT presented the highest values for sensitivity (0.98; 95%CI: 0.96-0.99) and positive likelihood ratio values (+LR) (4.88; 95%CI: 0.85-28.17). Therefore, it seemed to address contemporary growth trends, as it presented great accuracy for diagnosing obesity in this sample of adolescents from northeastern Brazil. FAU - Oliveira, Mariane Helen de AU - Oliveira MH AUID- ORCID: 0000-0002-6552-3430 AD - School of Social Work, Boston College. 140 Commonwealth Ave. 02467 Chestnut Hill MA USA. marianehelen@yahoo.com.br. FAU - Ferrari, Gerson AU - Ferrari G AUID- ORCID: 0000-0003-3177-6576 AD - Escuela de Ciencias de la Actividad Fisica, el Deporte y la Salud, Universidad de Santiago de Chile. Santiago Chile. FAU - Cabral, Breno Guilherme de Araujo Tinoco AU - Cabral BGAT AUID- ORCID: 0000-0001-5953-7572 AD - Departamento de Educacao Fisica, Centro de Ciencias da Saude, Universidade Federal do Rio Grande do Norte. Natal RN Brasil. FAU - Dantas, Paulo Moreira Silva AU - Dantas PMS AUID- ORCID: 0000-0002-9217-7107 AD - Departamento de Educacao Fisica, Centro de Ciencias da Saude, Universidade Federal do Rio Grande do Norte. Natal RN Brasil. FAU - Costa, Roberto Fernandes da AU - Costa RFD AUID- ORCID: 0000-0002-8789-1744 AD - Facultad de Ciencias de la Salud. Universidad Autonoma de Chile. Santiago Chile. LA - eng PT - Journal Article DEP - 20240728 PL - Brazil TA - Cien Saude Colet JT - Ciencia & saude coletiva JID - 9713483 SB - IM MH - Humans MH - Adolescent MH - Brazil/epidemiology MH - *Nutritional Status MH - Male MH - Female MH - Body Mass Index MH - Child MH - Young Adult MH - *Pediatric Obesity/epidemiology/diagnosis MH - Absorptiometry, Photon MH - Reference Values MH - Prevalence MH - Cross-Sectional Studies MH - Sensitivity and Specificity EDAT- 2025/08/13 12:29 MHDA- 2025/08/31 20:07 CRDT- 2025/08/13 11:54 PHST- 2024/02/26 00:00 [received] PHST- 2024/07/26 00:00 [accepted] PHST- 2025/08/31 20:07 [medline] PHST- 2025/08/13 12:29 [pubmed] PHST- 2025/08/13 11:54 [entrez] AID - S1413-81232025000700908 [pii] AID - 10.1590/1413-81232025307.03122024 [doi] PST - ppublish SO - Cien Saude Colet. 2025 Jul;30(7):e03122024. doi: 10.1590/1413-81232025307.03122024. Epub 2024 Jul 28. PMID- 40802220 OWN - NLM STAT- MEDLINE DCOM- 20250825 LR - 20250825 IS - 2509-8020 (Electronic) IS - 2509-8020 (Linking) VI - 9 IP - 1 DP - 2025 Aug 13 TI - Psychometric evaluation of the EQ-5D-Y-3L in Ethiopian pediatric inpatients: comparing self and proxy reports. PG - 100 LID - 10.1186/s41687-025-00928-8 [doi] LID - 100 AB - BACKGROUND: Limited evidence exists regarding the measurement properties of the EQ-5D-Y-3L across different modes of administration. This study aimed to examine changes in parent/caregiver-child/adolescent dyad agreement concerning health-related quality of life (HRQoL) over time, assess variations in health status according to socio-demographic factors, and evaluate the responsiveness of the EQ-5D-Y-3L within a pediatric population in Ethiopia. METHODS: The study was conducted at the University of Gondar Comprehensive Specialized Hospital, involving children/adolescents aged 4-18 years admitted to the pediatric inpatient unit. Children/adolescents completed the EQ-5D-Y-3L self-complete version at admission and discharge, while parents/caregivers completed the proxy version. Health status was analyzed utilizing the EQ-5D-Y-3L descriptive profiles, utility values, and the EuroQol Visual Analogue Scale (EQ VAS) scores, categorized by age, gender, and residence. Agreement between parent/caregiver and child/adolescent reports was evaluated using weighted Cohen's kappa for dimension levels and the intraclass correlation coefficient (ICC) for utility and EQ VAS scores. Responsiveness was assessed through paired t-tests and the Paretian Classification of Health Change (PCHC) analysis, which classifies health status changes as improved, worsened, mixed, or unchanged based on changes across EQ-5D dimensions. RESULTS: A total of 957 children/adolescents, with a mean age of 10.7 +/- 4.3 years, along with their parents/caregivers, participated in the study. The predominant diagnoses included pneumonia, meningitis, malaria, malnutrition, and glomerulonephritis. Both child/adolescent and parent/caregiver reports indicated poorer health status among older adolescents (13-18 years), boys from rural areas. Agreement on the EQ-5D-Y-3L dimension levels was fair to moderate at admission (weighted kappa ranging from 0.28 to 0.38) and was poorer at discharge for the 'worried, sad or unhappy' dimension (weighted kappa of 0.15). Agreement on utility and EQ VAS scores was acceptable at both admission and discharge (ICC: 0.498-0.676), with moderate to good agreement observed among children/adolescents aged 7-16 years. However, agreement on utility scores decreased at discharge for older boys (13-18 years old) and urban residents, while it increased for the younger age group (4-6 years old). Responsiveness analysis demonstrated significant improvements in the dimensions of 'Looking After Myself,' 'Mobility,' and 'Worried, Sad or Unhappy,' with most children/adolescents exhibiting health improvements according to PCHC criteria. CONCLUSION: Parent/caregiver-child/adolescent dyad agreement concerning HRQoL was low to moderate and varied according to socio-demographic factors. The EQ-5D-Y-3L instrument demonstrated responsiveness to changes in health status, supporting its utility in pediatric populations. These findings underscore the importance of employing age-appropriate and context-sensitive HRQoL assessment tools in pediatric care and health policy. Incorporating both child/adolescent and parent/caregiver perspectives can inform clinical decisions and resource allocation, especially in low-resource settings. Further research is warranted to explore factors influencing these variations and to enhance understanding of their underlying causes. CI - (c) 2025. The Author(s). FAU - Gebresillassie, Begashaw Melaku AU - Gebresillassie BM AD - School of Medicine and Public Health, University of Newcastle, Newcastle, Australia. begashaw531@gmail.com. AD - School of Pharmacy, University of Gondar, Gondar, Ethiopia. begashaw531@gmail.com. FAU - Belay, Yared Belete AU - Belay YB AD - School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia. FAU - Netere, Adeladlew Kassie AU - Netere AK AD - School of Pharmacy, University of Gondar, Gondar, Ethiopia. AD - Faculty of Pharmacy and Pharmaceutical Science, Monash University, Melbourne, Australia. FAU - Gu, Ning Yan AU - Gu NY AD - School of Nursing and Health Professions, University of San Francisco, California, USA. LA - eng GR - 436-RA/EuroQol Research Foundation/ PT - Journal Article DEP - 20250813 PL - Germany TA - J Patient Rep Outcomes JT - Journal of patient-reported outcomes JID - 101722688 SB - IM MH - Humans MH - Child MH - Ethiopia MH - Male MH - Female MH - Adolescent MH - *Quality of Life/psychology MH - Child, Preschool MH - Psychometrics MH - *Proxy MH - *Health Status MH - *Self Report MH - *Inpatients/psychology MH - Parents/psychology MH - Surveys and Questionnaires MH - Caregivers/psychology PMC - PMC12350999 OTO - NOTNLM OT - EQ-5D-Y-3L OT - Ethiopia OT - Parent/caregiver-child/adolescent agreement OT - Responsiveness COIS- Declarations. Ethics approval and consent to participate: We obtained ethical approval from the University of Gondar's Institutional Review Board with the reference number: VP/RTT/05/750/22, ensuring compliance with ethical standards in research involving human participants. To fully inform participants about the study, we provided a summary detailing the study's purpose, along with informed consent forms for parents/caregivers and assent forms for children/adolescents. These documents were designed to be clear and comprehensive, ensuring that all participants and their guardians provided informed and voluntary consent before participation. The process of obtaining informed consent and assent was conducted in accordance with the ethical guidelines laid out by the Institutional Review Board, prioritizing participant understanding and voluntary participation. To ensure data privacy and security, all personal identifiers were removed from datasets before analysis. Hard copies of consent forms and clinical data were stored in locked cabinets accessible only to the core research team. Electronic data were password-protected and stored on encrypted devices. Data access was strictly limited to authorized personnel involved in the study. Furthermore, all data were anonymized during reporting to prevent identification of individual participants. Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests. EDAT- 2025/08/13 12:29 MHDA- 2025/08/31 20:07 PMCR- 2025/08/13 CRDT- 2025/08/13 11:36 PHST- 2024/11/11 00:00 [received] PHST- 2025/07/15 00:00 [accepted] PHST- 2025/08/31 20:07 [medline] PHST- 2025/08/13 12:29 [pubmed] PHST- 2025/08/13 11:36 [entrez] PHST- 2025/08/13 00:00 [pmc-release] AID - 10.1186/s41687-025-00928-8 [pii] AID - 928 [pii] AID - 10.1186/s41687-025-00928-8 [doi] PST - epublish SO - J Patient Rep Outcomes. 2025 Aug 13;9(1):100. doi: 10.1186/s41687-025-00928-8. PMID- 40801387 OWN - NLM STAT- MEDLINE DCOM- 20251210 LR - 20251210 IS - 1099-0968 (Electronic) IS - 1072-4133 (Linking) VI - 34 IP - 1 DP - 2026 Jan TI - Heterogeneous Presentations at Admission But Similar Treatment Response Across Latent Profiles of ARFID Prototypes in Children and Adolescents. PG - 229-239 LID - 10.1002/erv.70024 [doi] AB - BACKGROUND: Avoidant/restrictive food intake disorder (ARFID) is defined by any combination of three prototypic motivations for dietary restriction (sensory-based avoidance, lack of interest, fear of aversive consequences), resulting in heterogeneous presentations. Some work suggests overlap of prototypes, but little is known about how prototypes cluster together. Further, little research exists on how prototype influences outcome. METHODS: We applied latent profile analysis (LPA) to 159 treatment-seeking children and adolescents (ages 9-18, 63% female, 78% White) with ARFID using items assessing ARFID prototype on the Eating Disorders in Youth-Questionnaire (EDY-Q). Resulting profiles were compared on clinical presentation and change in ARFID, anxiety, and depressive symptoms following evidence-based higher-level-of-care treatment. RESULTS: ARFID prototypes present heterogeneously. A 4-profile solution emerged from the LPA: ARFID-1 (with fear of aversive consequences; n = 26); ARFID-2 (with sensory-based avoidance and lack of interest; n = 43); ARFID-3 (with all three prototypes; n = 44); and Non-Endorsers (n = 53). While profiles differed on ARFID, anxiety, and depressive symptoms at admission, change in symptoms was similar across profiles. CONCLUSIONS: ARFID prototypes frequently overlap. Despite heterogeneity of ARFID prototypes, treatment outcome was similar across latent profiles, supporting continued categorisation of all these motivations for restrictive eating as ARFID. Future work is needed to further validate these profiles. CI - (c) 2025 Eating Disorders Association and John Wiley & Sons Ltd. FAU - Abber, Sophie R AU - Abber SR AD - Department of Psychology, Florida State University, Tallahassee, Florida, USA. FAU - Velimirovic, Mina AU - Velimirovic M AUID- ORCID: 0000-0001-5685-7933 AD - Department of Psychology, Florida State University, Tallahassee, Florida, USA. AD - University of Novi Sad Faculty of Philosophy, Novi Sad, Serbia. FAU - Sigel, Anika N AU - Sigel AN AD - Department of Psychology, Florida State University, Tallahassee, Florida, USA. FAU - Duffy, Alan AU - Duffy A AD - Eating Recovery Center, Denver, Colorado, USA. AD - Pathlight Mood and Anxiety Center, Denver, Colorado, USA. FAU - Manwaring, Jamie AU - Manwaring J AUID- ORCID: 0000-0002-7798-0612 AD - Eating Recovery Center, Denver, Colorado, USA. AD - Pathlight Mood and Anxiety Center, Denver, Colorado, USA. AD - ACUTE at Denver Health, Denver, Colorado, USA. FAU - Rienecke, Renee AU - Rienecke R AUID- ORCID: 0000-0003-0423-7403 AD - Eating Recovery Center, Denver, Colorado, USA. AD - Pathlight Mood and Anxiety Center, Denver, Colorado, USA. AD - Department of Psychiatry and Behavioral Sciences, Northwestern University, Evanston, Illinois, USA. FAU - Le Grange, Daniel AU - Le Grange D AUID- ORCID: 0000-0001-7293-9496 AD - Department of Psychiatry and Behavioral Sciences, University of California San Francisco School of Medicine, San Francisco, California. AD - Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, Illinois, USA. FAU - Blalock, Dan V AU - Blalock DV AUID- ORCID: 0000-0002-8349-9825 AD - Center of Innovation to Accelerate Discovery and Practice Transformation, Durham Veterans Affairs Medical Center, Durham, North Carolina, USA. AD - Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA. FAU - Mehler, Philip S AU - Mehler PS AUID- ORCID: 0000-0002-9598-6428 AD - Eating Recovery Center, Denver, Colorado, USA. AD - Pathlight Mood and Anxiety Center, Denver, Colorado, USA. AD - ACUTE at Denver Health, Denver, Colorado, USA. AD - Department of Internal Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA. FAU - Riddle, Megan AU - Riddle M AD - ACUTE at Denver Health, Denver, Colorado, USA. AD - Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA. FAU - Joiner, Thomas E AU - Joiner TE AD - Department of Psychology, Florida State University, Tallahassee, Florida, USA. LA - eng PT - Journal Article DEP - 20250813 PL - England TA - Eur Eat Disord Rev JT - European eating disorders review : the journal of the Eating Disorders Association JID - 9436977 SB - IM MH - Humans MH - Adolescent MH - Child MH - Female MH - Male MH - *Avoidant Restrictive Food Intake Disorder/therapy/diagnosis/psychology/classification MH - Anxiety/psychology MH - Depression MH - Motivation OTO - NOTNLM OT - avoidant/restrictive food intake disorder OT - classification OT - feeding and eating disorders EDAT- 2025/08/13 12:30 MHDA- 2025/12/10 19:21 CRDT- 2025/08/13 08:05 PHST- 2025/07/09 00:00 [revised] PHST- 2025/01/27 00:00 [received] PHST- 2025/08/07 00:00 [accepted] PHST- 2025/12/10 19:21 [medline] PHST- 2025/08/13 12:30 [pubmed] PHST- 2025/08/13 08:05 [entrez] AID - 10.1002/erv.70024 [doi] PST - ppublish SO - Eur Eat Disord Rev. 2026 Jan;34(1):229-239. doi: 10.1002/erv.70024. Epub 2025 Aug 13. PMID- 40800069 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250816 IS - 2326-9901 (Electronic) IS - 2326-9901 (Linking) VI - 12 IP - 2 DP - 2025 TI - Pre-analytical considerations for microRNA quantification in childhood leukemia research. PG - e99010062 LID - 10.14440/jbm.2025.0001 [doi] LID - e99010062 AB - BACKGROUND: MicroRNAs (miRNAs) have gained significant attention as potential biomarkers in childhood leukemia, offering insights into diagnosis, prognosis, and therapeutic targeting. However, the clinical translation of miRNA biomarkers faces several challenges, including inconsistencies in results caused by methodological differences, sample processing variability, and a lack of standardized normalization techniques. In addition, miRNA profiles are highly cell-specific, with unique signatures for different blood cell types and leukemic blasts, reflecting their distinct biological roles and disease states. Pre-analytical factors are critical in ensuring the accuracy and reproducibility of miRNA quantification. The selectively enriched and highly stable exosomal miRNAs have shown great promise for studying intercellular communication and disease-specific miRNAs. The selection of the analytical matrix should align with the specific objectives of the research or diagnostic application. Addressing technical challenges and recording potential confounding variables (e.g., age, gender, ethnicity, body mass index, menstrual cycle, fasting, circadian rhythm, comorbidities, medications, smoking, and physical activity) are essential to enhancing the reproducibility and reliability of miRNA biomarkers. OBJECTIVE: This review aims to highlight the challenges facing miRNA quantification in childhood leukemias, scrutinizing all relevant pre-analytical issues, including the preferred specimen source, leukemic blast type and count, the selection of suitable blood components, the impact of time and freeze-thaw cycles, collection, processing, and storage variables. CONCLUSION: Further research is needed to standardize methodologies and expand our understanding of miRNA interaction networks, ultimately advancing the application of miRNAs in childhood leukemia research. CI - Copyright: (c) 2025 Author(s). FAU - Kyriakidis, Ioannis AU - Kyriakidis I AD - Department of Pediatric Hematology-Oncology and Autologous Hematopoietic Stem Cell Transplantation Unit, University Hospital of Heraklion and Laboratory of Blood Diseases and Childhood Cancer Biology, School of Medicine, University of Crete, Heraklion 71003, Greece. FAU - Pelagiadis, Iordanis AU - Pelagiadis I AD - Department of Pediatric Hematology-Oncology and Autologous Hematopoietic Stem Cell Transplantation Unit, University Hospital of Heraklion and Laboratory of Blood Diseases and Childhood Cancer Biology, School of Medicine, University of Crete, Heraklion 71003, Greece. FAU - Stiakaki, Eftichia AU - Stiakaki E AD - Department of Pediatric Hematology-Oncology and Autologous Hematopoietic Stem Cell Transplantation Unit, University Hospital of Heraklion and Laboratory of Blood Diseases and Childhood Cancer Biology, School of Medicine, University of Crete, Heraklion 71003, Greece. LA - eng PT - Journal Article PT - Review DEP - 20250527 PL - United States TA - J Biol Methods JT - Journal of biological methods JID - 101639022 PMC - PMC12342214 OTO - NOTNLM OT - Adolescence OT - Biomarker OT - Childhood OT - Confounding factors OT - Exosomes OT - Leukemia OT - MicroRNAs OT - Pre-analytical phase COIS- The authors declare they have no competing interests. EDAT- 2025/08/13 06:30 MHDA- 2025/08/13 06:31 PMCR- 2025/05/27 CRDT- 2025/08/13 05:58 PHST- 2025/01/01 00:00 [received] PHST- 2025/03/26 00:00 [revised] PHST- 2025/04/15 00:00 [accepted] PHST- 2025/08/13 06:31 [medline] PHST- 2025/08/13 06:30 [pubmed] PHST- 2025/08/13 05:58 [entrez] PHST- 2025/05/27 00:00 [pmc-release] AID - 10.14440/jbm.2025.0001 [doi] PST - epublish SO - J Biol Methods. 2025 May 27;12(2):e99010062. doi: 10.14440/jbm.2025.0001. eCollection 2025. PMID- 40799526 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250816 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - Causal insights into the school-family-research integrated health promotion program for overweight and obesity: the independent role of moderate-to-vigorous physical activity in body fat reduction, undermined by psychological factors. PG - 1577319 LID - 10.3389/fnut.2025.1577319 [doi] LID - 1577319 AB - INTRODUCTION: This study implements the School-Family-Research Integrated Health Promotion Program for Overweight and Obesity (SFR-OO), which combines exercise and dietary interventions to combat adolescent obesity. It aims to enhance body composition, exercise motivation, SE, and physical fitness. By using a cross-lagged model, the study will explore causal relationships between self-esteem (SE), exercise self-efficacy (ESE), physical activity, and body composition. METHODS: Ninety-eight adolescents were randomly assigned to either the intervention group or the control group. The intervention group received the SFR-OO intervention for 12 weeks. Assessments included physical fitness tests, body composition, and psychological indicators. RESULTS: While both groups showed a time effect (p < 0.001), the intervention resulted in a significant decrease in body fat percentage (BFP) compared to the control group (p < 0.001, p < 0.038). Improvements were greater for knee push-ups, standing long jump, 4 x 10 meters round trip run and supine trunk raise time as well as psychometric measures (p < 0.001). In the intervention group, higher baseline MVPA significantly predicted greater reductions in BFP at 12 weeks (beta = -0.169), whereas no such predictive relationship was found in the control group. DISCUSSION: The 12-week SFR-OO effectively enhanced adolescents' body composition, physical fitness, and psychological outcomes. However, SE and ESE did not significantly predict MVPA or BFP. MVPA modestly predicted reduced BFP only within the intervention group, suggesting a context-dependent effect. This study was registered with ClinicalTrials.gov under the registration number NCT06524908. CI - Copyright (c) 2025 Zhang, Pan, Liu, Gao, Jiang, Chen, Zhao, Wang, Hu, Zhao, Lu, Suzuki and Zhang. FAU - Zhang, Xuehui AU - Zhang X AD - College of Sports Science, Hefei Normal University, Hefei, China. FAU - Pan, Xiang AU - Pan X AD - China Institute of Sport Science, Beijing, China. AD - Graduate School of Health and Sports Science, Juntendo University, Inzai, Japan. FAU - Liu, Bing AU - Liu B AD - School of Literature and Journalism, Yantai University, Yantai, China. FAU - Gao, Yibo AU - Gao Y AD - China Institute of Sport Science, Beijing, China. FAU - Jiang, Lupei AU - Jiang L AD - China Institute of Sport Science, Beijing, China. FAU - Chen, Xiaoxiao AU - Chen X AD - China Institute of Sport Science, Beijing, China. AD - College of Physical Education and Sports Rehabilitation, Jinzhou Medical University, Jinzhou, China. FAU - Zhao, Deqiang AU - Zhao D AD - China Institute of Sport Science, Beijing, China. FAU - Wang, Yibei AU - Wang Y AD - China Institute of Sport Science, Beijing, China. FAU - Hu, Haixia AU - Hu H AD - Weifang Aiyoudong Children and Youth Sports Health Research Institute, Weifang, China. FAU - Zhao, Xueli AU - Zhao X AD - Department of Psychology, Qingdao University, Qingdao, China. FAU - Lu, Jiahui AU - Lu J AD - China Institute of Sport Science, Beijing, China. FAU - Suzuki, Koya AU - Suzuki K AD - Graduate School of Health and Sports Science, Juntendo University, Inzai, Japan. AD - Institute of Health and Sports Science & Medicine, Juntendo University, Inzai, Japan. FAU - Zhang, Yanfeng AU - Zhang Y AD - China Institute of Sport Science, Beijing, China. LA - eng SI - ClinicalTrials.gov/NCT06524908 PT - Journal Article DEP - 20250729 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12339317 OTO - NOTNLM OT - adolescent OT - body composition OT - cross-lagged model OT - exercise self-efficacy OT - obesity OT - physical activity OT - physical fitness OT - self-esteem COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/08/13 06:29 MHDA- 2025/08/13 06:30 PMCR- 2025/07/29 CRDT- 2025/08/13 05:50 PHST- 2025/02/28 00:00 [received] PHST- 2025/07/11 00:00 [accepted] PHST- 2025/08/13 06:30 [medline] PHST- 2025/08/13 06:29 [pubmed] PHST- 2025/08/13 05:50 [entrez] PHST- 2025/07/29 00:00 [pmc-release] AID - 10.3389/fnut.2025.1577319 [doi] PST - epublish SO - Front Nutr. 2025 Jul 29;12:1577319. doi: 10.3389/fnut.2025.1577319. eCollection 2025. PMID- 40797325 OWN - NLM STAT- MEDLINE DCOM- 20250827 LR - 20250830 IS - 1749-799X (Electronic) IS - 1749-799X (Linking) VI - 20 IP - 1 DP - 2025 Aug 12 TI - Validation of the Turkish version of the knee Osteoarthritis outcome score -child questionnaire. PG - 763 LID - 10.1186/s13018-025-06169-1 [doi] LID - 763 AB - BACKGROUND: The present study aims to bridge this gap by evaluating the reliability, construct validity, and discriminatory capacity of the Turkish The Knee Osteoarthritis Outcome Score -Child Questionnaire (KOOS-Child). METHODS: The questionnaire was translated from English to Turkish by two Turkish speaking orthopedic surgeons. Following consensus, the translated version was retranslated to English by a professional translator. A group of experts compared the original and back translated version and decided on a final adapted questionnaire version The study included 119 participants (61 knee problem patients and 58 control patients) aged 8 to 16 years between July 2020 and January 2025. The patients were asked to fill out the KOOS-Child questionnaire and the Children's Quality of Life Questionnaire, which had previously been validated in Turkish. While the demographic characteristics of the groups (age, gender, body mass index (BMI), amount of sports activity) and KOOS-Child Questionnaire scores were compared between the groups, the internal consistency of both groups was examined. In addition, the construct validity and discrimination capacity of the knee pain group were evaluated. RESULTS: When demographic characteristics of the groups were compared, the number of professional athletes in the knee pain group was statistically higher. (p < 0.05) When the KOOS Child Questionnaire scores were compared between the groups, both the subscales and the total score of the knee pain group were low (p < 0.05) It was seen that the knee pain group had high level of internal consistency of other subscales and total scores in both groups, except for the symptoms subscale. In the patient group with knee trauma, it was observed that pain, ADL and quality of life and total scores of the girls were lower than the boys (p < 0.05). CONCLUSION: The Turkish KOOS-Child questionnaire exhibits excellent reliability and validity, serving as a practical tool for assessing pediatric knee health, particularly in capturing pain and functional limitations. CI - (c) 2025. The Author(s). FAU - Akpolat, Ahmet Onur AU - Akpolat AO AUID- ORCID: 0000-0001-7773-5476 AD - Orthopedics Surgery and Traumatology Department, University of Health Science, Fatih Sultan Mehmet Training and Research Hospital, Atasehir/Istanbul, 34856, Turkey. onurakpolat@hotmail.com. FAU - Gultekin, Onur AU - Gultekin O AUID- ORCID: 0000-0002-0836-076X AD - Orthopedics Surgery and Traumatology Department, University of Health Science, Fatih Sultan Mehmet Training and Research Hospital, Atasehir/Istanbul, 34856, Turkey. FAU - Arikan, Halil Ibrahim AU - Arikan HI AUID- ORCID: 0009-0007-5787-7785 AD - Orthopedics Surgery and Traumatology Department, University of Health Science, Fatih Sultan Mehmet Training and Research Hospital, Atasehir/Istanbul, 34856, Turkey. FAU - Sen, Ahmet Eren AU - Sen AE AUID- ORCID: 0009-0005-7053-5873 AD - Orthopedics Surgery and Traumatology Department, University of Health Science, Fatih Sultan Mehmet Training and Research Hospital, Atasehir/Istanbul, 34856, Turkey. FAU - Kilinc, Bekir Eray AU - Kilinc BE AUID- ORCID: 0000-0003-1229-9815 AD - Orthopedics Surgery and Traumatology Department, University of Health Science, Fatih Sultan Mehmet Training and Research Hospital, Atasehir/Istanbul, 34856, Turkey. LA - eng PT - Journal Article PT - Validation Study DEP - 20250812 PL - England TA - J Orthop Surg Res JT - Journal of orthopaedic surgery and research JID - 101265112 SB - IM EIN - J Orthop Surg Res. 2025 Aug 30;20(1):811. doi: 10.1186/s13018-025-06251-8. PMID: 40885963 MH - Humans MH - *Osteoarthritis, Knee/diagnosis MH - Male MH - Female MH - Child MH - Turkey MH - Surveys and Questionnaires/standards MH - Adolescent MH - Reproducibility of Results MH - Quality of Life MH - Translations PMC - PMC12344914 OTO - NOTNLM OT - Cross-cultural adaptation OT - KOOS-child OT - Pediatric OT - Turkish OT - Validation COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/08/13 06:30 MHDA- 2025/09/08 08:07 PMCR- 2025/08/12 CRDT- 2025/08/13 00:47 PHST- 2025/05/14 00:00 [received] PHST- 2025/07/31 00:00 [accepted] PHST- 2025/09/08 08:07 [medline] PHST- 2025/08/13 06:30 [pubmed] PHST- 2025/08/13 00:47 [entrez] PHST- 2025/08/12 00:00 [pmc-release] AID - 10.1186/s13018-025-06169-1 [pii] AID - 6169 [pii] AID - 10.1186/s13018-025-06169-1 [doi] PST - epublish SO - J Orthop Surg Res. 2025 Aug 12;20(1):763. doi: 10.1186/s13018-025-06169-1. PMID- 40796899 OWN - NLM STAT- MEDLINE DCOM- 20250825 LR - 20250825 IS - 1824-7288 (Electronic) IS - 1720-8424 (Linking) VI - 51 IP - 1 DP - 2025 Aug 12 TI - Obesity‑related kidney disease: a review on ultrasound applications. PG - 251 LID - 10.1186/s13052-025-02090-9 [doi] LID - 251 AB - Pediatric obesity is a growing global health concern, associated with metabolic, cardiovascular, and kidney complications. Early identification and intervention are crucial to preventing long-term morbidity. This review examines the epidemiology, pathophysiology, and clinical implications of childhood obesity, focusing on its impact on kidney health. We discuss non-invasive diagnostic tools, including kidney ultrasound, and evidence-based management strategies. Obesity in children is linked to hypertension, insulin resistance, and early signs of kidney dysfunction, including increased kidney echogenicity and hyperfiltration. Ultrasound findings may serve as early markers of kidney involvement, potentially guiding risk stratification and intervention. Addressing pediatric obesity requires a multidisciplinary approach, incorporating lifestyle modifications, medical management, and early detection of organ damage. The aim of this narrative review is to summarize the pathophysiology of pediatric obesity-related kidney damage, current evidence on ultrasound-based screening, and possible diagnostic techniques. Further research is needed to validate ultrasound as a routine screening tool for obesity-related kidney disease in children. CI - (c) 2025. The Author(s). FAU - Di Ludovico, Armando AU - Di Ludovico A AD - Department of Pediatrics, University of Chieti"G. D'Annunzio", Chieti, Italy. FAU - Pucci, Costanza AU - Pucci C AD - Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. FAU - Grassi, Giovanni AU - Grassi G AD - Department of Radiology, Azienda Ospedaliero Universitaria (A.O.U.) di Cagliari - Polo di Monserrato, Cagliari, Italy. FAU - Chabert, Gian Luca AU - Chabert GL AD - Department of Radiology, Azienda Ospedaliero Universitaria (A.O.U.) di Cagliari - Polo di Monserrato, Cagliari, Italy. FAU - Ledda, Giuseppe AU - Ledda G AD - Department of Radiology, Azienda Ospedaliero Universitaria (A.O.U.) di Cagliari - Polo di Monserrato, Cagliari, Italy. FAU - Mascioli, Ilaria AU - Mascioli I AD - Department of Pediatrics, University of Chieti"G. D'Annunzio", Chieti, Italy. FAU - La Bella, Saverio AU - La Bella S AD - Department of Pediatrics, University of Chieti"G. D'Annunzio", Chieti, Italy. AD - UOC Rheumatology and Autoinflammatory Diseases, IRCCS Istituto Giannina Gaslini, Genoa, Italy. FAU - Ciarelli, Francesca AU - Ciarelli F AD - Department of Pediatrics, University of Chieti"G. D'Annunzio", Chieti, Italy. FAU - Breda, Luciana AU - Breda L AD - Department of Pediatrics, University of Chieti"G. D'Annunzio", Chieti, Italy. FAU - Giannini, Cosimo AU - Giannini C AD - Department of Pediatrics, University of Chieti"G. D'Annunzio", Chieti, Italy. FAU - Mohn, Angelika AU - Mohn A AD - Department of Pediatrics, University of Chieti"G. D'Annunzio", Chieti, Italy. FAU - Chiarelli, Francesco AU - Chiarelli F AD - Department of Pediatrics, University of Chieti"G. D'Annunzio", Chieti, Italy. FAU - Corsello, Antonio AU - Corsello A AUID- ORCID: 0000-0003-4578-0066 AD - Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. antonio.corsello@unimi.it. AD - Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy. antonio.corsello@unimi.it. LA - eng PT - Journal Article PT - Review DEP - 20250812 PL - England TA - Ital J Pediatr JT - Italian journal of pediatrics JID - 101510759 SB - IM MH - Humans MH - Ultrasonography/methods MH - *Pediatric Obesity/complications MH - Child MH - *Kidney Diseases/diagnostic imaging/etiology/physiopathology/epidemiology PMC - PMC12344850 OTO - NOTNLM OT - Doppler OT - Kidney OT - Metabolic syndrome OT - Nephrology OT - Obesity OT - Pediatric ultrasound COIS- Declarations. Ethics approval and consent to participate: Ultrasound images are original and were acquired with parental approval with written informed consent from parent. Consent for publication: Imaging data were collected under University of Chieti "G. D'Annunzio" protocol for use of anonymized images, after collecting consent from parents. Competing interests: The authors declare that they have no competing interests. EDAT- 2025/08/13 00:27 MHDA- 2025/08/31 20:07 PMCR- 2025/08/12 CRDT- 2025/08/12 23:38 PHST- 2025/05/01 00:00 [received] PHST- 2025/07/26 00:00 [accepted] PHST- 2025/08/31 20:07 [medline] PHST- 2025/08/13 00:27 [pubmed] PHST- 2025/08/12 23:38 [entrez] PHST- 2025/08/12 00:00 [pmc-release] AID - 10.1186/s13052-025-02090-9 [pii] AID - 2090 [pii] AID - 10.1186/s13052-025-02090-9 [doi] PST - epublish SO - Ital J Pediatr. 2025 Aug 12;51(1):251. doi: 10.1186/s13052-025-02090-9. PMID- 40795085 OWN - NLM STAT- MEDLINE DCOM- 20250826 LR - 20250826 IS - 1536-7290 (Electronic) IS - 1746-1391 (Print) IS - 1536-7290 (Linking) VI - 25 IP - 9 DP - 2025 Sep TI - The Effects of Familiarisation on Countermovement Jumps with Handheld Dumbbell Accentuated Eccentric Loading in Youth Athletes. PG - e70033 LID - 10.1002/ejsc.70033 [doi] LID - e70033 AB - This study was used to investigate the effects of familiarisation on a countermovement jump (CMJ) performed with handheld dumbbell accentuated eccentric loading (AEL) at 20% of body mass (CMJ(AEL20)). Twenty-seven adolescent males performed CMJ(AEL20) on three separate occasions. Statistical parametric mapping (SPM) detected significant differences in normalised force-time data between session one and two (50%-95% of movement time), two and three (47%-48%) and one and three (66%-96%), but not in velocity- or displacement-time data. Propulsion mean vertical ground reaction force (vGRF) had excellent reliability (CV% upper CI(95) = 5.12-9.33; ICC lower CI(95) = 0.99), whereas jump height exhibited good relative reliability (ICC lower CI(95) >/= 0.94) but moderate to poor absolute reliability (CV% upper CI(95) = 6.72-15.36). Unweighting time and braking time showed moderate to poor reliability (CV% upper CI(95) = 14.22-37.06; ICC lower CI(95) = 0.46-0.89). Mean bias between sessions was 20%). Proportional bias was identified in unweighting vGRF%, braking mean vGRF and braking mean velocity. These findings suggest that although more than three familiarisation sessions may be required for unweighting and braking CMJ(AEL20) variables, reliable propulsion data, including jump height, were observed from session one. CI - (c) 2025 The Author(s). European Journal of Sport Science published by Wiley-VCH GmbH on behalf of European College of Sport Science. FAU - Bright, Thomas E AU - Bright TE AUID- ORCID: 0000-0001-8089-817X AD - Youth Physical Development Centre, School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK. AD - School of Sport, Exercise and Rehabilitation, Plymouth Marjon University, Plymouth, UK. FAU - Lake, Jason AU - Lake J AD - Institute of Sport, Nursing, and Allied Health, University of Chichester, Chichester, UK. FAU - Handford, Matthew J AU - Handford MJ AD - U7 Performance, Exeter, UK. FAU - Theis, Nicola AU - Theis N AD - School of Sport and Exercise, University of Gloucestershire, Gloucester, UK. FAU - Mundy, Peter AU - Mundy P AD - Hawkin Dynamics Inc., Westbrook, Maine, USA. FAU - Hughes, Jonathan D AU - Hughes JD AUID- ORCID: 0000-0002-9905-8055 AD - Youth Physical Development Centre, School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK. LA - eng PT - Journal Article PL - Germany TA - Eur J Sport Sci JT - European journal of sport science JID - 101146739 SB - IM MH - Humans MH - Male MH - Adolescent MH - Reproducibility of Results MH - *Athletic Performance/physiology MH - Biomechanical Phenomena MH - Athletes MH - *Plyometric Exercise MH - *Exercise Test/instrumentation/methods MH - Movement PMC - PMC12342230 OTO - NOTNLM OT - eccentric training OT - jumping OT - learning effect OT - long-term athlete development OT - statistical parametric mapping COIS- The authors declare no conflicts of interest. EDAT- 2025/08/12 18:34 MHDA- 2025/09/08 08:07 PMCR- 2025/08/12 CRDT- 2025/08/12 14:53 PHST- 2025/06/25 00:00 [revised] PHST- 2024/12/03 00:00 [received] PHST- 2025/07/29 00:00 [accepted] PHST- 2025/09/08 08:07 [medline] PHST- 2025/08/12 18:34 [pubmed] PHST- 2025/08/12 14:53 [entrez] PHST- 2025/08/12 00:00 [pmc-release] AID - EJSC70033 [pii] AID - 10.1002/ejsc.70033 [doi] PST - ppublish SO - Eur J Sport Sci. 2025 Sep;25(9):e70033. doi: 10.1002/ejsc.70033. PMID- 40794540 OWN - NLM STAT- MEDLINE DCOM- 20260203 LR - 20260203 IS - 2391-5854 (Electronic) IS - 0033-2674 (Linking) VI - 59 IP - 6 DP - 2025 Dec 31 TI - When eating inedible things: Determining the prevalence of pica disorder in a group of Polish adolescents aged 15-19 years. PG - 917-934 LID - 202942 [pii] LID - 10.12740/PP/OnlineFirst/202942 [doi] AB - OBJECTIVES: This study aimed to determine the prevalence of pica among Polish adolescents aged 15-19 years, to identify the most commonly consumed inedible substances, and independent factors that increase the risk of pica. METHODS: The study was conducted with the participation of 1,696 secondary school students from all over Poland. Multiple random sampling was used. A three-part self-designed questionnaire, which included recall questions, diagnostic questions for pica disorder and an assessment of mental state was used in the study. The study assessed the relationships between selected variables, characteristics for other eating disorders, and drinking (e.g. place of residence, level of physical activity, having siblings or level of parental education). The questionnaire was validated before the study. RESULTS: 3.2% of respondents ate starch in the form of raw flour, paper or tissue, 5.7% ate nasal discharge and 0.2% ate glass particles. 1.5% of respondents needed to see a specialist because they had eaten a non-nutritive substance. 10% of respondents characterized the severity of family stress above the 90th percentile, similarly, 9.4% of respondents described the high severity of school stress. 37.1% of the respondents engaged in self-injurious behavior. CONCLUSIONS: Diagnostic criteria for pica were met by 5.7% of respondents. The most common non-nutritive substances consumed by respondents were: nasal discharge, raw starch and hair. Independent factors that increased the risk of pica included living in a city, the presence of self-aggressive behavior, the presence of suicidal thoughts and high levels of stress at school. FAU - Gorski, Michal Kamil AU - Gorski MK AD - Zaklad Medycyny i Higieny Pracy, Katedra Chorob Przewleklych i Zagrozen Cywilizacyjnych, Wydzial Zdrowia Publicznego w Bytomiu, Slaski Uniwersytet Medyczny, Polska. FAU - Polaniak, Renata AU - Polaniak R AD - Zaklad Zywienia Czlowieka, Katedra Dietetyki, Wydzial Zdrowia Publicznego w Bytomiu, Slaski Uniwersytet Medyczny, Polska. FAU - Calyniuk, Beata AU - Calyniuk B AD - Zaklad Zywienia Czlowieka, Katedra Dietetyki, Wydzial Zdrowia Publicznego w Bytomiu, Slaski Uniwersytet Medyczny, Polska. FAU - Buczkowska, Marta AU - Buczkowska M AD - Zaklad Medycyny i Higieny Pracy, Katedra Chorob Przewleklych i Zagrozen Cywilizacyjnych, Wydzial Zdrowia Publicznego w Bytomiu, Slaski Uniwersytet Medyczny, Polska. FAU - Fojcik, Joanna AU - Fojcik J AD - Gornoslaskie Centrum Medyczne im. Leszka Gieca Slaskiego Uniwersytetu Medycznego w Katowicach, Oddzial Rehabilitacji Psychiatrycznej, Polska. FAU - Borowska-Malinowska, Jolanta AU - Borowska-Malinowska J AD - Zaklad Medycyny i Higieny Pracy, Katedra Chorob Przewleklych i Zagrozen Cywilizacyjnych, Wydzial Zdrowia Publicznego w Bytomiu, Slaski Uniwersytet Medyczny, Polska. FAU - Domagalska, Joanna AU - Domagalska J AD - Zaklad Srodowiskowych Czynnikow Ryzyka Zdrowotnego, Katedra Zdrowia Srodowiskowego, Wydzial Zdrowia Publicznego w Bytomiu, Slaski Uniwersytet Medyczny, Polska. FAU - Antoniak-Sobczak, Katarzyna AU - Antoniak-Sobczak K AD - Katedra Geriatrii, Wydzial Nauk o Zdrowiu w Katowicach, Slaski Uniwersytet Medyczny w Katowicach, Katowice, Polska. FAU - Gorska, Karolina AU - Gorska K AD - Studenckie Kolo Naukowe, Uniwersytet Pedagogiczny im. Komisji Edukacji Narodowej, Krakow, Polska. FAU - Pluta, Judyta AU - Pluta J AD - Instytut Pielegniarstwa i Poloznictwa, Wydzial Nauk o Zdrowiu, Uniwersytet Jagiellonski, Collegium Medicum, Krakow, Polska. FAU - Scislo, Lucyna AU - Scislo L AD - Instytut Pielegniarstwa i Poloznictwa, Wydzial Nauk o Zdrowiu, Uniwersytet Jagiellonski, Collegium Medicum, Krakow, Polska. LA - eng LA - pol PT - Journal Article TT - Kiedy niejadalne staje sie jedzeniem - okreslenie czestosci wystepowania picy w grupie polskich nastolatkow miedzy 15. a 19. rokiem zycia. DEP - 20251231 PL - Poland TA - Psychiatr Pol JT - Psychiatria polska JID - 0103314 SB - IM MH - Humans MH - Poland/epidemiology MH - *Pica/epidemiology/psychology MH - Adolescent MH - Female MH - Male MH - Prevalence MH - Young Adult MH - *Students/statistics & numerical data/psychology MH - *Feeding Behavior/psychology MH - *Adolescent Behavior/psychology MH - Surveys and Questionnaires MH - Risk Factors OTO - NOTNLM OT - eating disorders OT - not-otherwise specified eating disorders OT - pica EDAT- 2025/08/12 18:33 MHDA- 2026/02/03 07:41 CRDT- 2025/08/12 13:12 PHST- 2026/02/03 07:41 [medline] PHST- 2025/08/12 18:33 [pubmed] PHST- 2025/08/12 13:12 [entrez] AID - 202942 [pii] AID - 10.12740/PP/OnlineFirst/202942 [doi] PST - ppublish SO - Psychiatr Pol. 2025 Dec 31;59(6):917-934. doi: 10.12740/PP/OnlineFirst/202942. Epub 2025 Dec 31. PMID- 40790471 OWN - NLM STAT- MEDLINE DCOM- 20250812 LR - 20250816 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Aug 11 TI - Co-occurrence of maternal anemia and child undernutrition in Ethiopia: multilevel analysis of analysis of EDHS data (2005-2016). PG - 2722 LID - 10.1186/s12889-025-23961-0 [doi] LID - 2722 AB - INTRODUCTION: Approximately half of people worldwide suffer from micronutrient deficiencies and maternal and child undernutrition. Maternal and child undernutrition is a critical public health issue in low- and middle-income countries characterized by the coexistence of both conditions, which pose severe health challenges. Maternal micronutrient deficiency elevates the risk of malnutrition in children negatively affecting their health and development. The trends and determinants of the co-occurrence of maternal anemia and child undernutrition in Ethiopia is not well understood. OBJECTIVES: This study aims to assess the trends and determinants of the co-occurrence of maternal anemia and child undernutrition in Ethiopia using data from the Ethiopian Demographic and Health Surveys (EDHS) conducted between 2005 and 2016. METHODOLOGY: We conducted a community-based cross-sectional study using data from the 2005-2016 Ethiopia Demographic and Health Surveys. A total of 21,531 women-child pairs were included in the analysis, which was weighted to represent 23,210 pairs at the national level. All analyses were performed using Stata version 17. To assess variability between clusters we calculated the intraclass correlation coefficient. We used the median odds ratio to quantify unexplained heterogeneity and the proportional change in variance to evaluate model improvement across different regression models. Variables with a p-value less than 0.20 in the bivariable analysis were entered into the multivariable logistic regression model. Statistical significance was determined at a p-value less than 0.05 with 95% confidence level. RESULT: This study included weighted samples of 23,210 mothers with under-five children. The overall prevalence of CMACU in Ethiopia was found 12.41% (95% CI: 11.99, 12.84). Significant factors associated with CMACU included maternal education (primary: AOR = 0.82, 95% CI: 0.73, 0.92; secondary or higher: AOR = 0.69, 95% CI: 0.53, 0.90), household wealth (high-income: AOR = 0.78, 95% CI: 0.68, 0.89), birth interval (> 36 months: AOR = 0.83, 95% CI: 0.76, 0.90), child age (12-23 months: AOR = 2.82, 95% CI: 2.43, 3.27), birth type (multiple births: AOR = 1.53, 95% CI: 1.17, 2.00), contraceptive use (AOR = 0.64, 95% CI: 0.56, 0.72), maternal nutritional status (not undernourished: AOR = 0.72, 95% CI: 0.66, 0.79), media exposure (AOR = 0.90, 95% CI: 0.82, 0.99), residence (rural: AOR = 1.28, 95% CI: 1.05, 1.57), and region. CONCLUSION AND RECOMMENDATION: The prevalence of CMACU in Ethiopia was notably high. Variables significantly associated with CMACU were included maternal education, wealth index, birth interval, type of birth, child age, contraceptive use, maternal nutritional status, ANC visit, media exposure, place of residence, and region. To reduce CMACU in Ethiopia, it is essential to focus on educating mothers, improving their economic status, promoting family planning, raising awareness, and targeting high-risk regions for interventions during program and policy development. CI - (c) 2025. The Author(s). FAU - Aweke, Mekuriaw Nibret AU - Aweke MN AD - Department of Human Nutrition, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gonda City, Ethiopia. mekunib@gmail.com. FAU - Yitageasu, Gelila AU - Yitageasu G AD - Department of Environmental and Occupational Health and Safety, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Gonda City, Ethiopia. FAU - Agimas, Muluken Chanie AU - Agimas MC AD - Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Science, University of Gondar, Gondar, Gonda City, Ethiopia. FAU - Yismaw, Getaneh Awoke AU - Yismaw GA AD - Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Science, University of Gondar, Gondar, Gonda City, Ethiopia. FAU - Baffa, Lemlem Daniel AU - Baffa LD AD - Department of Human Nutrition, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gonda City, Ethiopia. FAU - Alemu, Gebrie Getu AU - Alemu GG AD - Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Science, University of Gondar, Gondar, Gonda City, Ethiopia. LA - eng PT - Journal Article DEP - 20250811 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Ethiopia/epidemiology MH - Female MH - Cross-Sectional Studies MH - *Anemia/epidemiology MH - Multilevel Analysis MH - Adult MH - Infant MH - Health Surveys MH - Young Adult MH - Child, Preschool MH - Adolescent MH - *Child Nutrition Disorders/epidemiology MH - Pregnancy MH - Male MH - Prevalence MH - *Malnutrition/epidemiology MH - Mothers/statistics & numerical data MH - Middle Aged PMC - PMC12337551 OTO - NOTNLM OT - Co-occurrence OT - Maternal Anemia OT - Maternal Health OT - Undernutrition COIS- Declarations. Ethics approval and consent to participate: Approval for using the EDHS dataset was obtained from the DHS Program/ICF International Inc., and the IRB of the DHS Program https://www.dhsprogram.com . The dataset is de-identified with randomized geographic coordinates to ensure privacy. No additional ethical review was required as there was no direct interaction with participants. We followed all DHS Program ethical guidelines. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/08/12 06:27 MHDA- 2025/08/12 06:28 PMCR- 2025/08/11 CRDT- 2025/08/12 00:36 PHST- 2025/03/22 00:00 [received] PHST- 2025/07/11 00:00 [accepted] PHST- 2025/08/12 06:28 [medline] PHST- 2025/08/12 06:27 [pubmed] PHST- 2025/08/12 00:36 [entrez] PHST- 2025/08/11 00:00 [pmc-release] AID - 10.1186/s12889-025-23961-0 [pii] AID - 23961 [pii] AID - 10.1186/s12889-025-23961-0 [doi] PST - epublish SO - BMC Public Health. 2025 Aug 11;25(1):2722. doi: 10.1186/s12889-025-23961-0. PMID- 40788143 OWN - NLM STAT- MEDLINE DCOM- 20260311 LR - 20260423 IS - 1461-7277 (Electronic) IS - 1359-1053 (Linking) VI - 31 IP - 4 DP - 2026 Mar TI - When helping hurts: Distinct pathways of positive and negative weight-related social control to behavioral and psychological outcomes. PG - 1469-1485 LID - 10.1177/13591053251358462 [doi] AB - Existing models of social control explaining how interpersonal influence is associated with behavioral and psychological outcomes show mixed empirical support. This research investigated psychological mechanisms linking weight-related social control (WRSC) to behavioral and psychological outcomes through two cross-sectional preregistered studies with U.S. adults recruited via CloudResearch Connect (combined N = 965). We used path analysis to develop and test a model examining how positive and negative WRSC relate to validated measures of exercise, dietary quality, drive for thinness, and bulimic tendencies, with psychological distress and body dissatisfaction as mediators. Negative WRSC consistently predicted outcomes through psychological distress, while its relationship with body dissatisfaction showed some sensitivity to outliers. Positive WRSC predicted both increased exercise and drive for thinness through direct pathways. These findings extend existing social control models by demonstrating distinct mechanisms linking positive and negative WRSC to behavioral and psychological outcomes. FAU - Tobin, Julie A AU - Tobin JA AUID- ORCID: 0000-0001-8186-7463 AD - Indiana University Kokomo, USA. FAU - Bliss, Carly M AU - Bliss CM AUID- ORCID: 0009-0003-6131-5284 AD - Indiana University Kokomo, USA. LA - eng PT - Journal Article DEP - 20250811 PL - England TA - J Health Psychol JT - Journal of health psychology JID - 9703616 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Cross-Sectional Studies MH - Exercise/psychology MH - Young Adult MH - Middle Aged MH - *Body Weight MH - Psychological Distress MH - *Body Image/psychology MH - Body Dissatisfaction/psychology MH - Thinness/psychology MH - Bulimia/psychology MH - Diet/psychology MH - Adolescent OTO - NOTNLM OT - body image OT - diet OT - exercise OT - social control OT - weight COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/08/11 12:33 MHDA- 2026/03/11 19:00 CRDT- 2025/08/11 09:45 PHST- 2026/03/11 19:00 [medline] PHST- 2025/08/11 12:33 [pubmed] PHST- 2025/08/11 09:45 [entrez] AID - 10.1177/13591053251358462 [doi] PST - ppublish SO - J Health Psychol. 2026 Mar;31(4):1469-1485. doi: 10.1177/13591053251358462. Epub 2025 Aug 11. PMID- 40784567 OWN - NLM STAT- MEDLINE DCOM- 20250912 LR - 20250912 IS - 1872-8227 (Electronic) IS - 0168-8227 (Linking) VI - 227 DP - 2025 Sep TI - Sex-specific thresholds of peak oxygen consumption for detecting cardiometabolic risk in children and adolescents with type 1 diabetes. PG - 112410 LID - S0168-8227(25)00424-3 [pii] LID - 10.1016/j.diabres.2025.112410 [doi] AB - AIMS: To establish sex-specific peak oxygen consumption (VO(2peak)) thresholds that accurately discriminate cardiometabolic risk (CMR) in children and adolescents with type 1 diabetes and to validate these cut-off points using an independent cohort. METHODS: This longitudinal study included 83 participants (aged 8-18 years) with type 1 diabetes from the Diactive-1 cohort. VO(2peak) was assessed via maximal exercise testing with direct gas analysis, and CMR was calculated using a composite z-score of waist circumference, lipid profile, HbA1c, and blood pressure. VO(2peak) thresholds for CMR were identified by sex using logistic regression and receiver operating characteristic analysis, and externally validated in a Brazilian cohort (n = 36). A total of 62 individuals completed the 2-year follow-up assessment. RESULTS: Optimal VO(2peak) thresholds were 40.8 ml/kg/min for boys and 33.7 ml/kg/min for girls, with areas under the curve of 0.71 and 0.78, respectively. Participants below these thresholds had significantly higher lipids and overall CMR. These associations persisted at the two-year follow-up and were confirmed in the Brazilian cohort, which also showed elevated HbA1c among high-risk individuals. CONCLUSIONS: Our study supports the clinical utility of these thresholds as a non-invasive marker of metabolic health and reinforce the importance of cardiorespiratory fitness promotion in this population. CI - Copyright (c) 2025 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Garcia-Hermoso, Antonio AU - Garcia-Hermoso A AD - Navarrabiomed, Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), IdiSNA, Pamplona, Spain. Electronic address: antonio.garciah@unavarra.es. FAU - Huerta-Uribe, Nidia AU - Huerta-Uribe N AD - Navarrabiomed, Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), IdiSNA, Pamplona, Spain. FAU - Hormazabal-Aguayo, Ignacio AU - Hormazabal-Aguayo I AD - Navarrabiomed, Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), IdiSNA, Pamplona, Spain; Vicerrectoria de Investigacion y Postgrado, Universidad de La Serena, La Serena, Chile. FAU - Munoz-Pardeza, Jacinto AU - Munoz-Pardeza J AD - Navarrabiomed, Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), IdiSNA, Pamplona, Spain. FAU - de Abreu de Lima, Valderi AU - de Abreu de Lima V AD - Federal University of Parana, Curitiba, Brazil. FAU - Leite, Neiva AU - Leite N AD - Federal University of Parana, Curitiba, Brazil. FAU - Nesi-Franca, Suzana AU - Nesi-Franca S AD - Federal University of Parana, Curitiba, Brazil. FAU - Yanez-Sepulveda, Rodrigo AU - Yanez-Sepulveda R AD - Faculty of Education and Social Sciences, Universidad Andres Bello, Vina del Mar, Chile. FAU - Hurtado-Almonacid, Juan AU - Hurtado-Almonacid J AD - eFidac grupo de de investigacion, Escuela de Educacion Fisica, Pontificia Universidad Catolica de Valparaiso, Chile. FAU - Ezzatvar, Yasmin AU - Ezzatvar Y AD - Lifestyle Factors with Impact on Ageing and Overall Health (LAH) Research Group. Department of Nursing. University of Valencia, Valencia, Spain; Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno, Chile. LA - eng PT - Journal Article DEP - 20250808 PL - Ireland TA - Diabetes Res Clin Pract JT - Diabetes research and clinical practice JID - 8508335 RN - 0 (Lipids) RN - 0 (hemoglobin A1c protein, human) RN - 0 (Glycated Hemoglobin) RN - 0 (Biomarkers) SB - IM MH - Longitudinal Studies MH - Spain/epidemiology MH - Logistic Models MH - Predictive Value of Tests MH - Humans MH - Male MH - Female MH - Child MH - *Sex Factors MH - Reference Values MH - *Risk Assessment/methods MH - Cardiometabolic Risk Factors MH - *Diabetes Mellitus, Type 1/blood/complications/pathology MH - Adolescent MH - *Metabolic Syndrome/diagnosis/epidemiology/etiology MH - Follow-Up Studies MH - *Oxygen Consumption/physiology MH - ROC Curve MH - Exercise Test MH - Waist Circumference MH - Lipids/blood MH - Glycated Hemoglobin/analysis MH - Blood Pressure MH - Biomarkers/analysis MH - Brazil/epidemiology OTO - NOTNLM OT - Aerobic fitness OT - Cardiometabolic disease OT - Insulin-dependent diabetes mellitus OT - Youth COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/08/11 00:26 MHDA- 2025/09/06 00:34 CRDT- 2025/08/10 19:37 PHST- 2025/05/02 00:00 [received] PHST- 2025/06/30 00:00 [revised] PHST- 2025/08/04 00:00 [accepted] PHST- 2025/09/06 00:34 [medline] PHST- 2025/08/11 00:26 [pubmed] PHST- 2025/08/10 19:37 [entrez] AID - S0168-8227(25)00424-3 [pii] AID - 10.1016/j.diabres.2025.112410 [doi] PST - ppublish SO - Diabetes Res Clin Pract. 2025 Sep;227:112410. doi: 10.1016/j.diabres.2025.112410. Epub 2025 Aug 8. PMID- 40783770 OWN - NLM STAT- MEDLINE DCOM- 20250810 LR - 20250812 IS - 1749-799X (Electronic) IS - 1749-799X (Linking) VI - 20 IP - 1 DP - 2025 Aug 9 TI - Safety and efficacy of robot-assisted technology in severe complex and non-severe spinal deformity correction: a retrospective comparative study. PG - 753 LID - 10.1186/s13018-025-06158-4 [doi] LID - 753 AB - BACKGROUND: Surgical correction of severe complex spinal deformities (SCD) poses significant technical challenges and carries a high risk of neurological complications. In recent years, robot-assisted (RA) technology has been increasingly adopted in spinal surgery, with theoretical advantages in enhancing surgical precision and safety, particularly in anatomically complex cases. However, its clinical outcomes in the correction of SCD have not been thoroughly evaluated. METHODS: A retrospective analysis was conducted on patients who underwent RA scoliosis correction surgery between January 2021 and April 2024. Patients were classified into non-severe deformities (NSD) and SCD groups based on the criteria of Cobb angle > 80 degrees , flexibility < 25%, or focal kyphosis > 90 degrees . Demographic data, surgical parameters, and imaging outcomes were collected and compared between the two groups. Primary outcomes included pedicle screw placement accuracy, major curve correction rates, operative time, intraoperative blood loss, hospital stay, and postoperative complications. A p-value < 0.05 was considered statistically significant. RESULTS: A total of 38 patients were included (NSD: 21, SCD: 17). No significant differences were observed between the groups in terms of age, sex distribution, BMI, or major curve region (p > 0.05). The SCD group exhibited significantly greater preoperative Cobb angles (93.69 degrees +/- 23.20 degrees vs. 51.05 degrees +/- 14.33 degrees , p < 0.0001) and kyphosis angles (102.65 degrees +/- 36.52 degrees vs. 37.77 degrees +/- 21.57 degrees , p < 0.0001) compared to the NSD group. There were no significant differences between the groups in the number of screws placed (18.35 +/- 7.00 vs. 16.86 +/- 7.77, p = 0.5414), operative time (277.35 +/- 68.81 min vs. 247.00 +/- 80.40 min, p = 0.2256), intraoperative blood loss (379.41 +/- 241.78 ml vs. 319.05 +/- 197.15 ml, p = 0.4019), or transfusion rates (23.53% vs. 23.81%, p = 1.0000). However, the SCD group had significantly longer hospital stays compared to the NSD group (27.65 +/- 9.64 days vs. 21.19 +/- 7.24 days, p = 0.0239). The complication rates were similar between the two groups (5.88% vs. 4.76%, p = 1.0000). Although the perfect screw placement rate in the SCD group was slightly lower than in the NSD group, the difference was not statistically significant (90.60% +/- 4.90% vs. 92.18% +/- 6.29%, p = 0.3997). Major curve correction rates also showed no significant difference between the groups (66.34% +/- 19.91% vs. 71.05% +/- 16.08%, p = 0.5134). CONCLUSION: This study demonstrates that RA technology achieves comparable pedicle screw placement accuracy and major curve correction rates in SCD patients relative to NSD patients, with no significant increase in complication rates. However, SCD patients may require longer hospital stays. These findings suggest that RA technology is a safe and effective strategy for SCD management, though broader implementation requires validation through larger prospective trials. Further large-scale, prospective studies are warranted to validate these results. CI - (c) 2025. The Author(s). FAU - Zhou, Lijin AU - Zhou L AD - Department of Orthopedic Surgery, Beijing Chaoyang Hospital, Capital Medical University of China, Gongti South Rd, No. 8, Beijing, 100020, China. doctorzhoulijin@163.com. AD - Center for Spinal Deformity, Capital Medical University, Beijing, China. doctorzhoulijin@163.com. AD - Joint Laboratory for Research &, Treatment of Spinal Cord Injury in Spinal Deformity, Capital Medical University of China, Beijing, China. doctorzhoulijin@163.com. FAU - Feng, Zihe AU - Feng Z AD - Department of Orthopedic Surgery, Beijing Chaoyang Hospital, Capital Medical University of China, Gongti South Rd, No. 8, Beijing, 100020, China. AD - Center for Spinal Deformity, Capital Medical University, Beijing, China. AD - Joint Laboratory for Research &, Treatment of Spinal Cord Injury in Spinal Deformity, Capital Medical University of China, Beijing, China. AD - Chinese Institutes for Medical Research, Beijing, China. FAU - Li, Zhangfu AU - Li Z AD - Department of Orthopedic Surgery, Beijing Chaoyang Hospital, Capital Medical University of China, Gongti South Rd, No. 8, Beijing, 100020, China. AD - Department of Orthopaedics, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Wang, Yunsheng AU - Wang Y AD - Department of Orthopedic Surgery, Beijing Chaoyang Hospital, Capital Medical University of China, Gongti South Rd, No. 8, Beijing, 100020, China. AD - Center for Spinal Deformity, Capital Medical University, Beijing, China. AD - Joint Laboratory for Research &, Treatment of Spinal Cord Injury in Spinal Deformity, Capital Medical University of China, Beijing, China. FAU - Hai, Yong AU - Hai Y AD - Department of Orthopedic Surgery, Beijing Chaoyang Hospital, Capital Medical University of China, Gongti South Rd, No. 8, Beijing, 100020, China. yong.hai@ccmu.edu.cn. AD - Center for Spinal Deformity, Capital Medical University, Beijing, China. yong.hai@ccmu.edu.cn. AD - Joint Laboratory for Research &, Treatment of Spinal Cord Injury in Spinal Deformity, Capital Medical University of China, Beijing, China. yong.hai@ccmu.edu.cn. AD - Chinese Institutes for Medical Research, Beijing, China. yong.hai@ccmu.edu.cn. LA - eng GR - 2022YFC2407206/National Key Research and Development Program of China/ GR - CX23YZ09/Organized research projects of Capital Medical Science Innovation Center/ PT - Comparative Study PT - Journal Article DEP - 20250809 PL - England TA - J Orthop Surg Res JT - Journal of orthopaedic surgery and research JID - 101265112 SB - IM MH - Humans MH - Retrospective Studies MH - Male MH - Female MH - *Robotic Surgical Procedures/methods/adverse effects MH - *Scoliosis/surgery/diagnostic imaging MH - Treatment Outcome MH - Adult MH - Pedicle Screws MH - Adolescent MH - Postoperative Complications/epidemiology/etiology MH - Kyphosis/surgery MH - Blood Loss, Surgical/statistics & numerical data MH - Young Adult MH - Operative Time MH - Length of Stay/statistics & numerical data MH - Middle Aged MH - *Spinal Fusion/methods MH - Severity of Illness Index PMC - PMC12335781 OTO - NOTNLM OT - Complications OT - Pedicle screw placement accuracy OT - Robot-assisted surgery OT - Severe complex deformity OT - Spinal deformity COIS- Declarations. Ethics approval and consent to participate: This retrospective study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of Beijing Chaoyang Hospital. Due to the retrospective nature of the study, the requirement for individual patient consent was waived by the ethics committee. Consent for publication: Not applicable as no individual person's data is contained in the manuscript. Competing interests: The authors declare no competing interests. EDAT- 2025/08/10 07:31 MHDA- 2025/08/10 07:32 PMCR- 2025/08/09 CRDT- 2025/08/10 00:18 PHST- 2025/06/03 00:00 [received] PHST- 2025/07/30 00:00 [accepted] PHST- 2025/08/10 07:32 [medline] PHST- 2025/08/10 07:31 [pubmed] PHST- 2025/08/10 00:18 [entrez] PHST- 2025/08/09 00:00 [pmc-release] AID - 10.1186/s13018-025-06158-4 [pii] AID - 6158 [pii] AID - 10.1186/s13018-025-06158-4 [doi] PST - epublish SO - J Orthop Surg Res. 2025 Aug 9;20(1):753. doi: 10.1186/s13018-025-06158-4. PMID- 40783637 OWN - NLM STAT- MEDLINE DCOM- 20250810 LR - 20250813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Aug 9 TI - Physical fitness status and associated determinants among Chinese children aged 9-12 years in Shandong province: a population-based cross-sectional study. PG - 29221 LID - 10.1038/s41598-025-13319-2 [doi] LID - 29221 AB - Children's physical fitness is a critical determinant of lifelong health, yet comprehensive investigations into its multi-level influencing factors remain limited, particularly in developing regions. Guided by the Ecological Model of Health Behavior, this cross-sectional study assessed the physical fitness status and associated determinants among 29,856 children aged 9-12 years in Shandong Province, China. Data were obtained from two primary sources: (1) standardized physical fitness assessments based on the National Physical Fitness Standards for Students of China (Revised 2014), and (2) validated questionnaires capturing individual behaviors, family environments, and lifestyle factors across multiple ecological levels. The physical fitness test qualification rate was adopted as the primary outcome indicator. Multivariable logistic regression analyses revealed that parental support for physical activity (OR = 0.297, 95% CI: 0.266-0.332), moderate-intensity exercise (OR = 0.872, 95% CI: 0.763-0.997), daily breakfast consumption (OR = 0.765, 95% CI: 0.626-0.936), and adequate sleep (6-8 h/day, OR = 0.569, 95% CI: 0.499-0.649) were significant protective factors for physical fitness test qualification. In contrast, daily exposure to secondhand smoke (OR = 1.212, 95% CI: 1.078-1.362), prolonged screen time (> 3 h/day, OR = 1.712, 95% CI: 1.496-1.958), and excessive academic burden (> 3 h/day, OR = 1.294, 95% CI: 1.158-1.447) were associated with increased risks of non-compliance. These findings underscore the multi-layered influences of personal behaviors, family dynamics, and environmental contexts on children's physical fitness, consistent with the socio-ecological framework. This study provides robust empirical evidence for the development of comprehensive, multi-sectoral interventions targeting child health promotion in school-aged populations. CI - (c) 2025. The Author(s). FAU - Wang, Wance AU - Wang W AD - The School of Physical Education and Health, East China Jiaotong University, Nan chang, China. FAU - Huang, Zhihao AU - Huang Z AD - School of Big Data and Fundamental Sciences, Shandong Institute of Petroleum an d Chemical Technology, Dongying, China. FAU - Gong, Jiahao AU - Gong J AD - Shandong Leke Engineering Design Co., Ltd., Dongying, China. FAU - Li, Qianqian AU - Li Q AD - Shandong University of Art and Design Jinan, Jinan, China. FAU - Liu, Guangwen AU - Liu G AD - The School of Physical Education and Health, East China Jiaotong University, Nan chang, China. FAU - Ge, Renkai AU - Ge R AD - The School of Physical Education and Health, East China Jiaotong University, Nan chang, China. rkcn@163.com. LA - eng GR - DYSK2023 No.308/The Social Sciences Planning Project of Dong ying/ GR - YC2024-S443/The Postgraduate Innovation Special Fund Project/ GR - 32260216/The National Natural Science Foundation of China (NSFC)/ PT - Journal Article DEP - 20250809 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - Chinese people SB - IM MH - Humans MH - *Physical Fitness/physiology MH - Child MH - Male MH - Female MH - Cross-Sectional Studies MH - China MH - Exercise MH - Surveys and Questionnaires MH - Life Style MH - Health Behavior MH - East Asian People PMC - PMC12335582 OTO - NOTNLM OT - Children OT - Influencing factors OT - Physical fitness COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/08/10 06:16 MHDA- 2025/08/10 07:31 PMCR- 2025/08/09 CRDT- 2025/08/09 23:50 PHST- 2025/03/11 00:00 [received] PHST- 2025/07/23 00:00 [accepted] PHST- 2025/08/10 07:31 [medline] PHST- 2025/08/10 06:16 [pubmed] PHST- 2025/08/09 23:50 [entrez] PHST- 2025/08/09 00:00 [pmc-release] AID - 10.1038/s41598-025-13319-2 [pii] AID - 13319 [pii] AID - 10.1038/s41598-025-13319-2 [doi] PST - epublish SO - Sci Rep. 2025 Aug 9;15(1):29221. doi: 10.1038/s41598-025-13319-2. PMID- 40783609 OWN - NLM STAT- MEDLINE DCOM- 20250813 LR - 20260925 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Aug 9 TI - The chain mediating role of emotion regulation and stress perception in physical activity alleviating college students' health anxiety. PG - 29189 LID - 10.1038/s41598-025-14481-3 [doi] LID - 29189 AB - Under the background of increasing social competition pressure and health awareness, health anxiety among college students is becoming more and more prominent, which seriously affects their physical and mental health and quality of life. This study aimed to explore the relationship between physical activity, emotion regulation, stress perception, and health anxiety among college students, and to examine the mediating roles of emotion regulation and stress perception in the process of physical activity affecting health anxiety, to provide a theoretical basis for interventions targeting college students' physical activity behaviors. In this study, a cross-sectional design was used to administer questionnaires to 518 academics from Ningxia University using four questionnaires, namely, Physical Activity Rating Scale, Emotional Regulation Scale, Stress Perception Scale, and Health Anxiety Scale. SPSS 27.0 was used for descriptive statistics, reliability analysis, correlation analysis, and regression analysis, and PROCESS 4.1 plug-in was used for chained mediation effect model analysis and testing. Physical activity was negatively associated with stress perception and health anxiety and positively associated with emotion regulation. Emotion regulation and stress perception acted as chain mediators in the process of physical exercise affecting health anxiety. The indirect effect value of the path PA-->PSS-->SHAI accounted for 56.87% of the total effect value, indicating that physical exercise is one of the key paths to reducing the health anxiety level of college students by regulating stress perception and then alleviating health anxiety. This study reveals for the first time the intermediary mechanism of "emotion regulation --> stress perception" of physical exercise to alleviate college students' health anxiety. At the theoretical level, a multilevel framework of physiological activation, cognitive regulation, and stress reconstruction was constructed; at the practical level, it provides a scientific basis for mental health intervention programs in colleges and universities and suggests that techniques such as Positive Mindfulness Exercise and Cognitive Behavioral Training can be integrated into physical exercise, which can effectively alleviate college students' health anxiety and promote their physical and mental health development by enhancing their emotion regulation ability and lowering the level of stress perception. CI - (c) 2025. The Author(s). FAU - Wang, Tianci AU - Wang T AD - Ningxia University School of Physical Education, Yinchuan, 750021, Ningxia, China. FAU - Nie, Yuyang AU - Nie Y AD - College of Education for the Future, Beijing Normal University, Zhuhai, 519087, Guangdong, P. R. China. AD - College of Physical Education and Sport, Beijing Normal University, Beijing, 100875, P. R. China. FAU - Yao, Xiansen AU - Yao X AD - Ningxia University School of Physical Education, Yinchuan, 750021, Ningxia, China. FAU - Zhang, Jiyun AU - Zhang J AD - Ningxia University School of Physical Education, Yinchuan, 750021, Ningxia, China. FAU - Li, Yanyue AU - Li Y AD - Ningxia University School of Physical Education, Yinchuan, 750021, Ningxia, China. FAU - Sun, Han AU - Sun H AD - Ningxia University School of Physical Education, Yinchuan, 750021, Ningxia, China. FAU - Gao, Jinchao AU - Gao J AD - College of Education for the Future, Beijing Normal University, Zhuhai, 519087, Guangdong, P. R. China. 91122008004@bnu.edu.cn. AD - College of Physical Education and Sport, Beijing Normal University, Beijing, 100875, P. R. China. 91122008004@bnu.edu.cn. LA - eng PT - Journal Article DEP - 20250809 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - *Students/psychology MH - Humans MH - *Anxiety/therapy MH - *Emotional Regulation MH - *Exercise MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - Bias MH - Male MH - Female MH - Adolescent MH - Young Adult PMC - PMC12335499 OTO - NOTNLM OT - Chain mediation OT - College students OT - Emotion regulation OT - Health anxiety OT - Physical activity OT - Stress perception COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical statement: This study has been approved by the Ethics Committee of the Department of Psychology, Beijing Normal University, and has obtained written informed consent from all subjects to ensure that they participate in this study on a voluntary basis. EDAT- 2025/08/10 06:16 MHDA- 2025/08/10 06:17 PMCR- 2025/08/09 CRDT- 2025/08/09 23:42 PHST- 2025/06/03 00:00 [received] PHST- 2025/07/31 00:00 [accepted] PHST- 2025/08/10 06:17 [medline] PHST- 2025/08/10 06:16 [pubmed] PHST- 2025/08/09 23:42 [entrez] PHST- 2025/08/09 00:00 [pmc-release] AID - 10.1038/s41598-025-14481-3 [pii] AID - 14481 [pii] AID - 10.1038/s41598-025-14481-3 [doi] PST - epublish SO - Sci Rep. 2025 Aug 9;15(1):29189. doi: 10.1038/s41598-025-14481-3. PMID- 40782843 OWN - NLM STAT- MEDLINE DCOM- 20250905 LR - 20250909 IS - 1872-8227 (Electronic) IS - 0168-8227 (Linking) VI - 227 DP - 2025 Sep TI - Responsive feeding, diabetes management, weight status and diet quality in a culturally diverse group of 1-5-year-old Australian children with type 1 diabetes. PG - 112402 LID - S0168-8227(25)00416-4 [pii] LID - 10.1016/j.diabres.2025.112402 [doi] AB - AIMS: To examine responsive feeding in culturally-and-linguistically diverse (CALD) Australian children (1-5 years) with type-1 diabetes (T1D) and associations with diabetes management, weight status and diet quality. METHODS: A retrospective, cross-sectional multi-centre study assessed parental feeding practices, child feeding behaviours, mealtime structure and child's dietary intake. RESULTS: 76 families participated with CALD parents more likely to engage in Reward for Behaviour (p = 0.02), Persuasive Feeding (p = 0.04) and Overt Restriction (p = 0.01). Eating > 2 meals/day in front of TV/screen was associated with Reward for Eating (p = 0.004), Persuasive Feeding (p = 0.01) and CALD background (p = 0.001). Children with HbA1c < 7.0 % experienced more Covert Restriction (p = 0.002). Those on multiple daily injections were more likely to be Rewarded for Eating (p = 0.04) and experience Persuasive Feeding (p = 0.02) but more Willing to try new foods (p = 0.01) compared to children using insulin pump therapy. Only 9 % met Australian recommendations for vegetables and 67 % exceeded recommendations for discretionary foods. CONCLUSIONS: Young children with T1D are not meeting healthy eating guidelines, with over half above a healthy weight. Exposure to non-responsive feeding practices is culturally sensitive and impacts diabetes management. A validated assessment tool identifies feeding and mealtime concerns, facilitating targeted conversations about not only what children eat, but also how they are fed. CI - Copyright (c) 2025. Published by Elsevier B.V. FAU - Lobley, Kristine AU - Lobley K AD - Institute of Endocrinology & Diabetes, The Children's Hospital at Westmead, Westmead, NSW 2145, Australia. Electronic address: kristine.lobley@health.nsw.gov.au. FAU - Youde, Lesley Sharon AU - Youde LS AD - Paediatric Diabetes and Endocrinology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia. Electronic address: sharon.youde@health.nsw.gov.au. FAU - Vandervliet, Leah AU - Vandervliet L AD - Nutrition and Dietetics, Sydney Children's Hospital, Randwick, NSW 2031, Australia. FAU - Wong, Hattie Hoi Ting AU - Wong HHT AD - Nutrition and Dietetics Group, School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Camperdown, NSW 2006, Australia. FAU - Weng, Jenny Jia Ni AU - Weng JJN AD - Nutrition and Dietetics Group, School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Camperdown, NSW 2006, Australia. FAU - Valakas, Stefanie AU - Valakas S AD - Nutrition and Dietetics Group, School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Camperdown, NSW 2006, Australia. Electronic address: hello@thedietologist.com.au. FAU - Jeyalingam, Marthury AU - Jeyalingam M AD - Nutrition and Dietetics Group, School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Camperdown, NSW 2006, Australia. Electronic address: marthery.jeyalingam@health.nsw.gov.au. FAU - Maguire, Ann M AU - Maguire AM AD - Institute of Endocrinology & Diabetes, The Children's Hospital at Westmead, Westmead, NSW 2145, Australia; Discipline of Child and Adolescent Health, Sydney Medical School, University of Sydney, Camperdown, NSW 2006, Australia. Electronic address: ann.maguire@health.nsw.gov.au. LA - eng PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20250807 PL - Ireland TA - Diabetes Res Clin Pract JT - Diabetes research and clinical practice JID - 8508335 SB - IM MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Australia/epidemiology MH - *Body Weight/physiology MH - Cross-Sectional Studies MH - *Diabetes Mellitus, Type 1/diet therapy MH - *Diet MH - *Feeding Behavior MH - Retrospective Studies OTO - NOTNLM OT - Culturally diverse OT - Diabetes OT - Diet quality OT - Glycemic control OT - Paediatric OT - Responsive feeding COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: One of the authors (Leah Vandervliet) has received honoraria from Abbott Nutrition. We declare that the remaining authors have no conflicts of interest to declare. EDAT- 2025/08/10 06:16 MHDA- 2025/09/06 00:35 CRDT- 2025/08/09 19:35 PHST- 2025/05/07 00:00 [received] PHST- 2025/07/21 00:00 [revised] PHST- 2025/07/31 00:00 [accepted] PHST- 2025/09/06 00:35 [medline] PHST- 2025/08/10 06:16 [pubmed] PHST- 2025/08/09 19:35 [entrez] AID - S0168-8227(25)00416-4 [pii] AID - 10.1016/j.diabres.2025.112402 [doi] PST - ppublish SO - Diabetes Res Clin Pract. 2025 Sep;227:112402. doi: 10.1016/j.diabres.2025.112402. Epub 2025 Aug 7. PMID- 40782624 OWN - NLM STAT- MEDLINE DCOM- 20250905 LR - 20250905 IS - 1873-6297 (Electronic) IS - 0001-6918 (Linking) VI - 259 DP - 2025 Sep TI - Antecedent and consequence of using O2O delivery applications: social anxiety, loneliness, and a moderated mediation model. PG - 105381 LID - S0001-6918(25)00694-8 [pii] LID - 10.1016/j.actpsy.2025.105381 [doi] AB - Online-to-offline delivery applications (ODAs), which link the mobile Internet to local physical businesses, offer prompt delivery of a wide range of items, including but not limited to food delivery. Frequent use of ODAs can be problematic. While the use of ODAs has been connected to physical health issues (e.g., unhealthy diet and sedentary behavior), its association with mental health concerns (e.g., social anxiety and loneliness) remains insufficiently addressed. Consequently, this study aims to explore the relationships among ODA usage, social anxiety, and loneliness by developing and validating a moderated mediation model. Data were derived from a three-phase online survey and subsequently analyzed applying partial least squares structural equation modeling alongside PROCESS analyses. The results show that social anxiety positively predicts ODA usage, and that such usage in turn positively predicts loneliness. Furthermore, ODA usage mediates the relationship between social anxiety and loneliness, and this indirect effect is moderated by living arrangement - being significantly stronger among consumers living alone. This study expands the scope of problematic technology use while providing nuanced practical insights for understanding consumer behavior and their psychological well-being. CI - Copyright (c) 2025 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Yao, Pinyi AU - Yao P AD - College of Business, Nanning University, Nanning 530200, China. Electronic address: yaopinyi@unn.edu.cn. FAU - Meng, Yongheng AU - Meng Y AD - College of Business, Nanning University, Nanning 530200, China. Electronic address: mengyongheng@unn.edu.cn. FAU - Fan, Wenjing AU - Fan W AD - Faculty of Human Ecology, Universiti Putra Malaysia, Serdang 43400, Malaysia. LA - eng PT - Journal Article DEP - 20250808 PL - Netherlands TA - Acta Psychol (Amst) JT - Acta psychologica JID - 0370366 SB - IM MH - Humans MH - *Loneliness/psychology MH - Female MH - Male MH - Adult MH - *Anxiety/psychology MH - Young Adult MH - *Mobile Applications/statistics & numerical data MH - Surveys and Questionnaires MH - Middle Aged MH - Mediation Analysis MH - Adolescent OTO - NOTNLM OT - Living alone OT - Loneliness OT - O2O delivery apps OT - Online-to-offline OT - Social anxiety COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/08/10 06:16 MHDA- 2025/09/05 06:35 CRDT- 2025/08/09 18:12 PHST- 2025/05/20 00:00 [received] PHST- 2025/07/21 00:00 [revised] PHST- 2025/08/04 00:00 [accepted] PHST- 2025/09/05 06:35 [medline] PHST- 2025/08/10 06:16 [pubmed] PHST- 2025/08/09 18:12 [entrez] AID - S0001-6918(25)00694-8 [pii] AID - 10.1016/j.actpsy.2025.105381 [doi] PST - ppublish SO - Acta Psychol (Amst). 2025 Sep;259:105381. doi: 10.1016/j.actpsy.2025.105381. Epub 2025 Aug 8. PMID- 40782563 OWN - NLM STAT- MEDLINE DCOM- 20251128 LR - 20251128 IS - 1873-5800 (Electronic) IS - 0968-0160 (Linking) VI - 57 DP - 2025 Dec TI - High-grade trochlear dysplasia is associated with a more negative sagittal tibial tuberosity-trochlear groove distance: A retrospective cohort study. PG - 1-11 LID - S0968-0160(25)00184-X [pii] LID - 10.1016/j.knee.2025.07.005 [doi] AB - PURPOSE: To identify demographic or radiographic predictors of sagittal tibial tuberosity-trochlear groove (sTT-TG) distance utilizing a cohort of patellofemoral surgical patients. METHODS: Patients who underwent an osteochondral allograft (OCA) transplantation or autologous chondrocyte implantation (ACI) from 2010 to 2020 were included if they had patellofemoral high-grade lesions and preoperative magnetic resonance imaging (MRI). Patient demographics, radiographic measurements such as coronal TT-TG, Caton-Deschamps index (CDI), and trochlear dysplasia were recorded. The preoperative sTT-TG distance was measured independently on axial T2-weighted MRI sequences by two authors at least two weeks apart. An interclass correlation coefficient (ICC) was calculated to assess intra- and inter-rater reliability of sTT-TG measurements, and univariate and multivariable linear regression models were used to assess the relationship between sTT-TG and any demographic or radiographic predictors. RESULTS: Seventy-three knees composed of 44 females and 29 males with a mean age of 31.0 +/- 10.1 years, a mean BMI of 26.8 +/- 6.1, and a mean follow-up of 60.4 +/- 21.0 months were included. Thirty-four of these (46.6 %) underwent OCA transplantations and 39 (53.4 %) underwent ACI/MACIs. Thirty-one (42.4 %) knees were determined to have evidence of trochlear dysplasia. Twenty-four patients were found to have high grade trochlear dysplasia (grades B, C and D) and 7 patients were found to have low grade trochlear dysplasia (grade A). The mean sTT-TG of the entire cohort was -5.3 +/- 4.9 mm. Interobserver reliability for sTT-TG measurements was excellent with an ICC of 0.95 (0.927-0.969, p < 0.001). There was a significant difference in sTT-TG between patients who had no trochlear dysplasia, low-grade trochlear dysplasia and high grade trochlear dysplasia (-3.51 +/- 3.96 vs. -6.17 +/- 4.29 vs. -9.25 +/- 5.32, p < 0.001). On multivariate regression, trochlear dysplasia remained the only significant predictor of sTT-TG (beta = -2.25, p = 0.005). Post-hoc analysis showed that both low- and high-grade dysplasia were associated with significantly more negative sTT-TG values compared to patients without dysplasia, though no significant difference was observed between the low- and high-grade groups. CONCLUSION: Trochlear dysplasia was associated with a more negative sagittal tibial tuberosity-trochlear groove (sTT-TG) distance, with increasing severity of trochlear dysplasia correlated with a relatively more posterior tibial tuberosity. LEVEL OF EVIDENCE: Level III; diagnostic cross-sectional study. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Bueno, Brian T AU - Bueno BT AD - NYU Langone Orthopedics, Division of Sports Medicine 333 E 38th St, 4th Floor, New York, NY 10016, United States. FAU - Moore, Michael R AU - Moore MR AD - NYU Langone Orthopedics, Division of Sports Medicine 333 E 38th St, 4th Floor, New York, NY 10016, United States. Electronic address: Michael.Moore@nyulangone.org. FAU - Bi, Andrew S AU - Bi AS AD - Midwest Orthopaedics at Rush, Division of Sports Medicine 1611 W Harrison St, Chicago, IL 60612, United States. FAU - Chen, Larry AU - Chen L AD - NYU Langone Orthopedics, Division of Sports Medicine 333 E 38th St, 4th Floor, New York, NY 10016, United States. FAU - Triana, Jairo AU - Triana J AD - NYU Langone Orthopedics, Division of Sports Medicine 333 E 38th St, 4th Floor, New York, NY 10016, United States. FAU - Jazrawi, Laith M AU - Jazrawi LM AD - NYU Langone Orthopedics, Division of Sports Medicine 333 E 38th St, 4th Floor, New York, NY 10016, United States. FAU - Gonzalez-Lomas, Guillem AU - Gonzalez-Lomas G AD - NYU Langone Orthopedics, Division of Sports Medicine 333 E 38th St, 4th Floor, New York, NY 10016, United States. FAU - Kaplan, Daniel J AU - Kaplan DJ AD - NYU Langone Orthopedics, Division of Sports Medicine 333 E 38th St, 4th Floor, New York, NY 10016, United States. LA - eng PT - Journal Article DEP - 20250808 PL - Netherlands TA - Knee JT - The Knee JID - 9430798 SB - IM MH - Humans MH - Female MH - Male MH - Retrospective Studies MH - Adult MH - *Tibia/diagnostic imaging/surgery/pathology MH - Magnetic Resonance Imaging MH - *Patellofemoral Joint/diagnostic imaging/surgery MH - Young Adult MH - Chondrocytes/transplantation MH - Adolescent MH - Knee Joint/diagnostic imaging/surgery OTO - NOTNLM OT - Patellar alta OT - Patellofemoral OT - Sagittal tibial tuberosity-trochlear groove distance OT - Trochlear dysplasia OT - sTT-TG COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/08/10 06:16 MHDA- 2025/11/29 02:21 CRDT- 2025/08/09 18:09 PHST- 2024/11/27 00:00 [received] PHST- 2025/06/26 00:00 [revised] PHST- 2025/07/03 00:00 [accepted] PHST- 2025/11/29 02:21 [medline] PHST- 2025/08/10 06:16 [pubmed] PHST- 2025/08/09 18:09 [entrez] AID - S0968-0160(25)00184-X [pii] AID - 10.1016/j.knee.2025.07.005 [doi] PST - ppublish SO - Knee. 2025 Dec;57:1-11. doi: 10.1016/j.knee.2025.07.005. Epub 2025 Aug 8. PMID- 40781297 OWN - NLM STAT- MEDLINE DCOM- 20250809 LR - 20250823 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 25 IP - 1 DP - 2025 Aug 8 TI - Influence of the active second stage of labor in nulliparous women on umbilical cord blood pH and neonatal outcomes: a population-based, cohort study. PG - 825 LID - 10.1186/s12884-025-07917-1 [doi] LID - 825 AB - BACKGROUND: Prolonged second stage of labor increases the risk of insufficient gas exchange over the placenta to the fetus and risk of birth asphyxia. There are considerable variations in clinical guidelines regarding the recommended duration of pushing during the active second stage of labor. Thus, the aim of this study was to investigate the total duration of the second stage of labor and its association to changes in umbilical cord pH and adverse neonatal outcomes in nulliparous women. METHODS: This retrospective, multi-center cohort study was based on data from the Perinatal Revision South Register covering seven maternity units from 1995 to 2015. Nulliparous women with fetuses in cephalic position and complete and validated cord blood pH data were recruited to the study. Logistic regression was used to establish the relationship of duration of pushing, categorized in 60 min increments, with cord blood acidosis (umbilical cord arterial pH < 7.05) and adverse neonatal outcomes, including Apgar score at 5 min, risk for central nervous system (CNS) disease, utilization of continuous positive airway pressure (CPAP), neonatal intensive care unit (NICU) admission and hypoxic ischemic encephalopathy (HIE). The adjusted model adjusted for maternal BMI, gestational duration and birth weight. RESULTS: A total of 37,008 women were included in the analysis. For every 60 min increase in pushing time, there was a significantly increased adjusted odds ratio (aOR) for umbilical arterial pH < 7.05, aOR = 1.639, (95% CI = 1.418-1.895, P = 0.02), Apgar score < 7 at 5-minutes, aOR = 1.408 (95% CI = 1.082-1.831, P = 0.01), and prevalence of suspected CNS disease, aOR = 1.417, (95% CI = 1.065-1.886, P = 0.02). The use of CPAP, (aOR = 1.215, 95% CI = 0.945-1.561, P = 0.13), NICU admission (aOR = 1.021, 95% CI = 0.890-1.171, P = 0.77), neonatal seizures (aOR = 0.000, P = 0.98) and HIE (aOR = 1.377, 95% CI = 0.416-4.109, P = 0.57) were not associated with increased pushing time. CONCLUSIONS: Using a large, population-based cohort, we found that prolonged active second stage of labor was associated with an increased odds for cord blood acidosis at birth, low Apgar score at 5 min, and suspected CNS-disease in neonates. Efficient and evidence-based time management during the active second stage of labor is therefore crucial for reducing the risk of adverse neonatal outcomes. CI - (c) 2025. The Author(s). FAU - Holmberg, Lisa AU - Holmberg L AD - Department of Clinical Sciences Lund, Lund University, Lund, Sweden. FAU - Iorizzo, Linda AU - Iorizzo L AD - Department of Clinical Sciences Lund, Lund University, Lund, Sweden. linda.iorizzo@med.lu.se. AD - Department of Obstetrics and Gynaecology, Skane University Hospital Lund, Lund, Sweden. linda.iorizzo@med.lu.se. AD - Department of Obstetrics & Gynecology, Lund University and Skane University Hospital Lund, Lund, 221 85, Sweden. linda.iorizzo@med.lu.se. FAU - Zaigham, Mehreen AU - Zaigham M AD - Department of Clinical Sciences Lund, Lund University, Lund, Sweden. AD - Department of Obstetrics and Gynaecology, Skane University Hospital Malmo, Malmo, Sweden. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20250808 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Fetal Blood/chemistry MH - *Labor Stage, Second/physiology/blood MH - Retrospective Studies MH - Infant, Newborn MH - Adult MH - Hydrogen-Ion Concentration MH - Apgar Score MH - *Acidosis/blood/epidemiology MH - Parity MH - Time Factors MH - Pregnancy Outcome/epidemiology MH - Intensive Care Units, Neonatal/statistics & numerical data MH - Cohort Studies MH - Hypoxia-Ischemia, Brain/epidemiology MH - Logistic Models PMC - PMC12333123 OTO - NOTNLM OT - Acidosis OT - Birth OT - Labor OT - Neonatal outcomes OT - Perinatal asphyxia OT - Second stage OT - Umbilical cord blood pH COIS- Declarations. Ethics approval and consent to participate: All methods were carried out in accordance with relevant guidelines or regulations in the Declaration of Helsinki. The study was approved by the Swedish Ethical Review Authority, Dnrs 2009/222, 2023-00434-02 and 2025-00585-01 and the requirement for informed consent was waived by Regional Ethics Committee in Lund due to the retrospective and population-based design of the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/08/09 13:46 MHDA- 2025/08/09 13:47 PMCR- 2025/08/08 CRDT- 2025/08/08 23:41 PHST- 2025/04/11 00:00 [received] PHST- 2025/07/07 00:00 [accepted] PHST- 2025/08/09 13:47 [medline] PHST- 2025/08/09 13:46 [pubmed] PHST- 2025/08/08 23:41 [entrez] PHST- 2025/08/08 00:00 [pmc-release] AID - 10.1186/s12884-025-07917-1 [pii] AID - 7917 [pii] AID - 10.1186/s12884-025-07917-1 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2025 Aug 8;25(1):825. doi: 10.1186/s12884-025-07917-1. PMID- 40775288 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Aug 7 TI - Association of the mediterranean diet with mental well-being: a cross-sectional study among adults living in Lebanon. PG - 2689 LID - 10.1186/s12889-025-23882-y [doi] LID - 2689 AB - BACKGROUND: The Mediterranean diet (MD) is regarded as one of the healthiest dietary patterns globally. It has been linked with numerous health benefits, including a reduced risk of chronic diseases and mental health disorders such as depression, anxiety, and stress. However, despite these findings, research on the relationship between the MD and overall mental well-being remains limited. To our knowledge, no nationwide study has been conducted on adults aged 18 years or older living in Lebanon to explore this association. OBJECTIVE: This study aims to explore the relationship between adhering to MD and mental well-being among adults living in Lebanon and determine predictors of mental well-being. METHODS: We conducted a survey-based cross-sectional study of 421 healthy participants in Lebanon which was mainly designed to measure mental well-being through the Warwick-Edinburg Mental Well-Being Scale (WEMWBS) and the adherence to MD through the Mediterranean Diet Scale (MDS) along with socio-demographics and lifestyle and health-related factors. Descriptive statistics were used to summarize the data. Independent two-sample t-test, One-way ANOVA, Welch's ANOVA and Spearman's correlation tests were applied in the bivariate analysis to examine the association between each variable and the WEMWEBS score. Subsequently, a hierarchical linear regression analysis was implemented for the multivariate analysis. RESULTS: After adjusting for confounding variables, a positive correlation was reported between MD adherence and mental well-being (B = 0.89, SE = 0.19, p < 0.001, 95% CI [0.51, 1.28]). No income, sleeping troubles, and alcohol consumption were associated with poorer mental well-being. A sub-analysis revealed that nuts and fish/seafood had the greatest positive impact on the variability of the WEMWBS score. CONCLUSION: This study highlighted the beneficial effect of adhering to MD on mental well-being among the residents in Lebanon. For future perspectives, a more representative sample is required to ensure the validity of the findings. FAU - Youssef, Razan AU - Youssef R AD - Faculty of Health Sciences, Modern University for Business and Science, Beirut, Lebanon. FAU - Najm, Daniel Bou AU - Najm DB AD - Faculty of Health Sciences, Modern University for Business and Science, Beirut, Lebanon. FAU - Al-Bourji, Malak AU - Al-Bourji M AD - Faculty of Health Sciences, Modern University for Business and Science, Beirut, Lebanon. FAU - Boutros, Paula Hage AU - Boutros PH AD - Faculty of Health Sciences, Modern University for Business and Science, Beirut, Lebanon. phage@mubs.edu.lb. LA - eng PT - Journal Article DEP - 20250807 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - *Diet, Mediterranean/statistics & numerical data/psychology MH - Lebanon MH - Cross-Sectional Studies MH - Adult MH - Female MH - Psychological Well-Being MH - Middle Aged MH - Male MH - *Mental Health/statistics & numerical data MH - Young Adult MH - Aged MH - Adolescent PMC - PMC12330095 OTO - NOTNLM OT - Cross-sectional study OT - Lebanon OT - Mediterranean diet OT - Nutrition OT - Mental well-being COIS- Declarations. Ethics approval and consent to participate: Authors confirm that ethical approval for this research project was obtained from the Institutional Review Board (IRB number: MU-20241106-47) at the Modern University of Business and Science (MUBS). This study was conducted based on the principles of the Declaration of Helsinki. Participants voluntarily completed an anonymous online survey, which implies that they possess a certain degree of literacy. Prior to participation, they read an explanation of the topic and their rights, ensuring that they fully understood their role in the study. Informed consent for participation was obtained from all participants, guaranteeing the protection of their confidentiality and anonymity. The data collected was used exclusively for scientific and research purposes. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/08/08 00:28 MHDA- 2026/06/27 00:52 PMCR- 2025/08/07 CRDT- 2025/08/07 23:34 PHST- 2025/03/03 00:00 [received] PHST- 2025/07/07 00:00 [accepted] PHST- 2026/06/27 00:52 [medline] PHST- 2025/08/08 00:28 [pubmed] PHST- 2025/08/07 23:34 [entrez] PHST- 2025/08/07 00:00 [pmc-release] AID - 10.1186/s12889-025-23882-y [pii] AID - 23882 [pii] AID - 10.1186/s12889-025-23882-y [doi] PST - epublish SO - BMC Public Health. 2025 Aug 7;25(1):2689. doi: 10.1186/s12889-025-23882-y. PMID- 40774985 OWN - NLM STAT- MEDLINE DCOM- 20250807 LR - 20250810 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Aug 7 TI - Ambulatory physiological measures obtained under naturalistic urban mobility conditions have acceptable reliability. PG - 28940 LID - 10.1038/s41598-025-13216-8 [doi] LID - 28940 AB - Ambulatory assessment methods in psychology and clinical neuroscience are powerful research tools for collecting data outside of the laboratory. These methods encompass physiological, behavioral, and self-report measures obtained while individuals navigate in real-world environments, thereby increasing the ecological validity of experimental approaches. Despite the recent increase in applications of ambulatory physiology, data on the reliability of these measures is still limited. To address this issue, twenty-six healthy participants (N = 15 female, 18-34 years) completed an urban walking route (distance M = 2.2 km, +/-SD = 0.11; duration M = 30.8 min, +/-SD = 1.34; temperature M = 18.34 degrees degree Celsius, +/-SD = 1.19, Range = 16 degrees -21 degrees degrees Celsius) on two separate testing days, while assessing the effect of metabolic state (sated vs. fasted). GPS-location and ambulatory physiological measures (cardiovascular and electrodermal activity) were continuously recorded. The results showed no significant differences in single physiological measures between fasted and sated states. Bootstrapped test-retest reliabilities of single measures and aggregate scores derived via principal component analysis (PCA) were computed. The first principal component (PC#1) accounted for 39-45% of variance across measures. PC#1 scores demonstrated an acceptable test-retest reliability (r = .60) across testing days, exceeding the reliabilities of most individual measures (heart rate: r = .53, heart rate variability: r = .50, skin conductance level: r = .53, no. of skin conductance responses: r = .28, skin conductance response amplitude: r = .60). Results confirm that ambulatory physiological measures recorded during naturalistic navigation in urban environments exhibit acceptable test-retest reliability, in particular when compound scores across physiological measures are analyzed, a prerequisite for applications in (clinical) psychology and digital health. CI - (c) 2025. The Author(s). FAU - Korkmaz, Dilber AU - Korkmaz D AD - Department of Psychology, Biological Psychology, University of Cologne, Cologne, Germany. d.korkmaz@uni-koeln.de. FAU - Knauth, Kilian AU - Knauth K AD - Department of Psychology, Biological Psychology, University of Cologne, Cologne, Germany. FAU - Brands, Angela AU - Brands A AD - Department of Psychology, Biological Psychology, University of Cologne, Cologne, Germany. FAU - Schmeck, Marie AU - Schmeck M AD - Department of Psychology, Biological Psychology, University of Cologne, Cologne, Germany. FAU - Buning, Pia AU - Buning P AD - Department of Psychology, Biological Psychology, University of Cologne, Cologne, Germany. FAU - Peters, Jan AU - Peters J AD - Department of Psychology, Biological Psychology, University of Cologne, Cologne, Germany. LA - eng PT - Journal Article DEP - 20250807 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Adult MH - Male MH - Young Adult MH - Reproducibility of Results MH - Adolescent MH - *Walking/physiology MH - Heart Rate/physiology MH - *Monitoring, Ambulatory/methods MH - Urban Population MH - Galvanic Skin Response/physiology PMC - PMC12332139 OTO - NOTNLM OT - Ambulatory assessment OT - Naturalistic environment OT - Psychophysiological monitoring OT - Reliability OT - Urban real-world COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/08/08 00:28 MHDA- 2025/08/08 00:29 PMCR- 2025/08/07 CRDT- 2025/08/07 23:17 PHST- 2024/12/18 00:00 [received] PHST- 2025/07/22 00:00 [accepted] PHST- 2025/08/08 00:29 [medline] PHST- 2025/08/08 00:28 [pubmed] PHST- 2025/08/07 23:17 [entrez] PHST- 2025/08/07 00:00 [pmc-release] AID - 10.1038/s41598-025-13216-8 [pii] AID - 13216 [pii] AID - 10.1038/s41598-025-13216-8 [doi] PST - epublish SO - Sci Rep. 2025 Aug 7;15(1):28940. doi: 10.1038/s41598-025-13216-8. PMID- 40774347 OWN - NLM STAT- MEDLINE DCOM- 20251023 LR - 20251023 IS - 1543-5474 (Electronic) IS - 1543-3080 (Linking) VI - 22 IP - 11 DP - 2025 Nov 1 TI - Increasing Physical Activity Among North American Sexual/Gender Diverse Adults: A Socioecological Approach. PG - 1401-1408 LID - 10.1123/jpah.2025-0138 [doi] AB - BACKGROUND: Sexual and/or gender diverse (nonheterosexual, non-cisgender; SGD) adults continue to report high rates of chronic condition incidence and prevalence, and reduced rates of physical activity (PA). However, interventions tailored to SGD individuals remain limited. This study sought to determine the effect of each level of socioecological model (SEM), (eg, individual, social, community/institution, environment) associated with meeting PA guidelines to inform intervention approaches. METHODS: Participants across North America (N = 300, non-Hispanic White [69.7%], cis-gendered women [40.7%], queer [38.3%], 18-34 y old [70.7%]) self-reported their current PA levels and PA correlates at each level of the SEM using multiple validated survey instruments via an online, anonymous survey. SEM level-specific survey instruments were combined to create a composite score for analyses. A hierarchical logistic regression was used to predict likelihood of meeting PA guidelines with each additional step adding a level of the SEM. Race/ethnicity, gender identity, sexual orientation, and income served as confounders. RESULTS: Each step in the model was significant; the level-specific correlates were significant predictors of meeting PA guidelines. In the final model (chi2[16] = 74.13, P < .001, R2 = .303), and across each model, general (B = 0.148, P < .001, odds ratio = 1.16) correlates at the individual level were significant predictors of higher odds of meeting PA guidelines. CONCLUSION: Tailored PA interventions should emphasize individual correlates of PA, in tandem with other SEM levels of influence to promote effective behavior change. Without intervention, SGD individuals may continue to experience chronic conditions at a higher rate compared with their peers. FAU - Peterson, Keegan T AU - Peterson KT AUID- ORCID: 0000-0002-6198-7502 AD - Department of Kinesiology, The Pennsylvania State University, University Park, PA, USA. FAU - Bopp, Melissa AU - Bopp M AUID- ORCID: 0000-0002-5170-9410 AD - Department of Kinesiology, The Pennsylvania State University, University Park, PA, USA. LA - eng PT - Journal Article DEP - 20250807 PL - United States TA - J Phys Act Health JT - Journal of physical activity & health JID - 101189457 SB - IM MH - Humans MH - Female MH - *Exercise MH - Male MH - Adult MH - Young Adult MH - Adolescent MH - North America MH - *Sexual and Gender Minorities/statistics & numerical data MH - Surveys and Questionnaires OTO - NOTNLM OT - LGBTQ+ OT - chronic disease OT - exercise OT - health promotion OT - intervention design EDAT- 2025/08/08 00:28 MHDA- 2025/10/23 12:29 CRDT- 2025/08/07 19:33 PHST- 2025/02/24 00:00 [received] PHST- 2025/03/31 00:00 [revised] PHST- 2025/05/30 00:00 [accepted] PHST- 2025/10/23 12:29 [medline] PHST- 2025/08/08 00:28 [pubmed] PHST- 2025/08/07 19:33 [entrez] AID - 10.1123/jpah.2025-0138 [doi] PST - epublish SO - J Phys Act Health. 2025 Aug 7;22(11):1401-1408. doi: 10.1123/jpah.2025-0138. Print 2025 Nov 1. PMID- 40774116 OWN - NLM STAT- MEDLINE DCOM- 20250924 LR - 20260728 IS - 1879-1379 (Electronic) IS - 0022-3956 (Linking) VI - 190 DP - 2025 Oct TI - Relationship between lifestyle, body composition, and psychological well-being in individuals with severe mental disorders: A comprehensive analysis. PG - 161-168 LID - S0022-3956(25)00479-0 [pii] LID - 10.1016/j.jpsychires.2025.07.041 [doi] AB - Severe mental disorders (SMD) are associated with a reduced life expectancy, influenced by factors such as obesity, sedentary behavior, poor nutrition, and social challenges, including stigma. Individuals with SMD face significant deficiencies in physical, psychological, and social health, with implications for their overall quality of life and well-being. Although these dimensions have been explored separately, there are few studies that integrate these variables to understand their interactions and guide more effective interventions. In this study, bioimpedance measurements, validated physical tests, and psychometric scales were used on a sample of 311 individuals with SMD, aged 18-68 years, from the Andalusia region (Southern Spain). Physical variables (fat mass, visceral fat, lean mass), eating habits, physical activity levels, and psychological variables (mental well-being and quality of life) were assessed. The results revealed high levels of body and visceral fat, insufficient lean mass, unbalanced diets with high consumption of ultra-processed foods, low levels of physical activity, and reduced scores in mental well-being and quality of life. Notably, linear regression analyses showed that time spent on physical activity was the only significant predictor of mental well-being and quality of life, while other measured variables did not show a significant effect. This highlights the unique contribution of physical activity in improving psychological outcomes for individuals with SMD. These findings underscore the need for comprehensive programs that combine strategies to improve diet, physical activity, and psychological well-being, promoting sustainable and effective physical activity programs to enhance the quality of life of individuals with SMD. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Lirola, Maria Jesus AU - Lirola MJ AD - University of Almeria, Department of Education, Carretera Sacramento, s/n, La Canada de San Urbano, 04120, Almeria, Spain; Universidad Internacional de La Rioja, Department of Psychology, Av. de la Paz, 137, Logrono, 26006, La Rioja, Spain; CiBiS: Research Center for Social Well-being and Inclusion, University of Almeria, Almeria, Spain. Electronic address: mariajesus.lirola@ual.es. FAU - Cangas, Adolfo J AU - Cangas AJ AD - University of Almeria, Department of Psychology, Carretera Sacramento, s/n, La Canada de San Urbano, 04120, Almeria, Spain; CiBiS: Research Center for Social Well-being and Inclusion, University of Almeria, Almeria, Spain. Electronic address: ajcangas@ual.es. FAU - Cerezuela, Juan Leandro AU - Cerezuela JL AD - University of Almeria, Department of Psychology, Carretera Sacramento, s/n, La Canada de San Urbano, 04120, Almeria, Spain; CiBiS: Research Center for Social Well-being and Inclusion, University of Almeria, Almeria, Spain. Electronic address: jcr320@ual.es. FAU - Lopez-Pardo, Andres AU - Lopez-Pardo A AD - Fundacion Publica Andaluza para la Integracion Social de Personas con Enfermedad Mental (FAISEM), Avenida de las Ciencias, 27, 41020, Sevilla, Spain; Mental Health Clinical Management Unit (UGC Salud Mental), Osuna Healthcare Management Area, Andalusian Health Service, Regional Government of Andalusia, Spain. Electronic address: andres.l.pardo@juntadeandalucia.es. LA - eng PT - Journal Article DEP - 20250805 PL - England TA - J Psychiatr Res JT - Journal of psychiatric research JID - 0376331 SB - IM MH - Humans MH - Adult MH - Middle Aged MH - Male MH - Female MH - *Body Composition/physiology MH - *Quality of Life/psychology MH - Young Adult MH - Aged MH - Adolescent MH - *Mental Disorders/psychology/physiopathology MH - *Life Style MH - Exercise/psychology MH - Spain MH - Psychological Well-Being OTO - NOTNLM OT - Body composition OT - Comprehensive intervention OT - Lifestyle OT - Physical activity OT - Quality of life COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/08/08 00:28 MHDA- 2025/09/25 00:28 CRDT- 2025/08/07 18:16 PHST- 2024/12/25 00:00 [received] PHST- 2025/06/07 00:00 [revised] PHST- 2025/07/29 00:00 [accepted] PHST- 2025/09/25 00:28 [medline] PHST- 2025/08/08 00:28 [pubmed] PHST- 2025/08/07 18:16 [entrez] AID - S0022-3956(25)00479-0 [pii] AID - 10.1016/j.jpsychires.2025.07.041 [doi] PST - ppublish SO - J Psychiatr Res. 2025 Oct;190:161-168. doi: 10.1016/j.jpsychires.2025.07.041. Epub 2025 Aug 5. PMID- 40773310 OWN - NLM STAT- MEDLINE DCOM- 20260331 LR - 20260704 IS - 1940-3208 (Electronic) IS - 0744-8481 (Linking) VI - 74 IP - 3 DP - 2026 Mar TI - Development of the drinking and physical activity motives scale. PG - 601-613 LID - 10.1080/07448481.2025.2541234 [doi] AB - Objective: Research has shown a positive relationship between alcohol use and physical activity. Although little is known about the factors that give rise to this association, evidence suggests intrinsic and extrinsic motivations underlie it. Participants: University students (N = 1691, 79% female, Age: M = 20.36, SD = 1.89) who completed an online assessment. Methods: A literature review identified five putative motives underlying the alcohol use <--> physical activity relation: (1) Work Hard, Play Hard (WHPH), (2) Stress, (3) Social, (4) Body Image (BI), and (5) Guilt, all domains assessed by the Drinking and Physical Activity Motives (DPAM) scale. Results: Confirmatory factor analysis followed by tests of measurement invariance across gender and race/ethnicity supported a partially invariant factor structure across all subgroups and associations with measures of drinking and physical activity. Conclusions: The DPAM will facilitate a better understanding the alcohol use <--> physical activity relationship, ultimately enhancing intervention efforts to reduce drinking among college students. FAU - Henderson, Craig E AU - Henderson CE AUID- ORCID: 0000-0003-2779-8879 AD - Department of Psychology, Sam Houston State University, Huntsville, Texas, USA. FAU - Leasure, J Leigh AU - Leasure JL AUID- ORCID: 0000-0002-9014-2525 AD - Department of Psychology, University of Houston, Houston, Texas, USA. FAU - Najjar, Laian Z AU - Najjar LZ AUID- ORCID: 0000-0001-5631-6862 AD - Department of Psychology, University of Houston, Houston, Texas, USA. FAU - Young, Chelsie M AU - Young CM AUID- ORCID: 0000-0003-1717-2434 AD - Department of Psychology, University of Houston, Houston, Texas, USA. FAU - Zhyrov, Vadym AU - Zhyrov V AUID- ORCID: 0000-0002-1414-3120 AD - Department of Psychology, University of Houston, Houston, Texas, USA. FAU - Christensen, Maxwell AU - Christensen M AUID- ORCID: 0000-0003-0559-0567 AD - Department of Psychology, Sam Houston State University, Huntsville, Texas, USA. FAU - Angosta, Joanne AU - Angosta J AUID- ORCID: 0000-0002-8006-7592 AD - Department of Psychology, University of Houston, Houston, Texas, USA. FAU - Neighbors, Clayton AU - Neighbors C AUID- ORCID: 0000-0002-9327-5278 AD - Department of Psychology, University of Houston, Houston, Texas, USA. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250807 PL - United States TA - J Am Coll Health JT - Journal of American college health : J of ACH JID - 8214119 SB - IM MH - Humans MH - Female MH - Male MH - *Motivation MH - *Students/psychology/statistics & numerical data MH - Universities/organization & administration MH - *Exercise/psychology MH - Young Adult MH - Surveys and Questionnaires MH - *Alcohol Drinking/psychology MH - Psychometrics/instrumentation/methods MH - Adult MH - Adolescent MH - Factor Analysis, Statistical MH - *Alcohol Drinking in College/psychology OTO - NOTNLM OT - Alcohol OT - exercise OT - measurement invariance OT - motivation OT - scale validation EDAT- 2025/08/07 18:27 MHDA- 2026/03/31 12:32 CRDT- 2025/08/07 12:23 PHST- 2026/03/31 12:32 [medline] PHST- 2025/08/07 18:27 [pubmed] PHST- 2025/08/07 12:23 [entrez] AID - 10.1080/07448481.2025.2541234 [doi] PST - ppublish SO - J Am Coll Health. 2026 Mar;74(3):601-613. doi: 10.1080/07448481.2025.2541234. Epub 2025 Aug 7. PMID- 40772342 OWN - NLM STAT- MEDLINE DCOM- 20260306 LR - 20260423 IS - 1461-7277 (Electronic) IS - 1359-1053 (Print) IS - 1359-1053 (Linking) VI - 31 IP - 3 DP - 2026 Mar TI - Food access relates to loss of control eating in adolescents with cardiometabolic conditions: Exploration of week-to-week variation. PG - 1192-1207 LID - 10.1177/13591053251354859 [doi] AB - The present study examined the relationship between food insecurity (FI) and loss of control eating (LOC) in adolescents treated for cardiometabolic conditions, and inter-connections among week-to-week variations in receipt of SNAP benefits, FI, and LOC. Forty-one adolescents presenting to cardiometabolic clinics completed validated surveys of FI and LOC. A subset of 20 adolescents experiencing FI completed 4 weekly e-surveys, over 1 month. Overall, 56% reported public assistance, 39% reported FI, and 37% reported LOC. FI related to greater LOC (beta = 0.17, p < 0.01). Among those with FI, receipt of SNAP related to greater within-person FI within the same week (beta = 0.60, p < 0.05) but not the following week (beta = -0.48, p = 0.20). FI related to greater LOC in the same week (beta = 0.17, p < 0.001) and in the following week (beta = 0.20, p < 0.001). In adolescents treated for cardiometabolic conditions, FI is prevalent and related to greater LOC. SNAP benefits might dampen FI week-to-week, but the effect of FI on LOC and cardiometabolic health should be explored causally. FAU - Bejarano, Carolina M AU - Bejarano CM AUID- ORCID: 0000-0001-5647-2144 AD - Cincinnati Children's Hospital Medical Center, USA. AD - Department of Pediatrics, University of Cincinnati College of Medicine, USA. FAU - Shomaker, Lauren AU - Shomaker L AUID- ORCID: 0000-0002-6129-8707 AD - Colorado State University, USA. AD - University of Colorado Anschutz Medical Campus, USA. FAU - Shah, Amy S AU - Shah AS AD - Cincinnati Children's Hospital Medical Center, USA. AD - Department of Pediatrics, University of Cincinnati College of Medicine, USA. FAU - Xanthakos, Stavra AU - Xanthakos S AD - Cincinnati Children's Hospital Medical Center, USA. AD - Department of Pediatrics, University of Cincinnati College of Medicine, USA. FAU - Ley, Sanita AU - Ley S AD - Cincinnati Children's Hospital Medical Center, USA. AD - Department of Pediatrics, University of Cincinnati College of Medicine, USA. FAU - Peugh, James AU - Peugh J AD - Cincinnati Children's Hospital Medical Center, USA. AD - Department of Pediatrics, University of Cincinnati College of Medicine, USA. FAU - Gonzalez-Louis, Rachel C AU - Gonzalez-Louis RC AD - Cincinnati Children's Hospital Medical Center, USA. FAU - Zeller, Meg H AU - Zeller MH AD - Cincinnati Children's Hospital Medical Center, USA. AD - Department of Pediatrics, University of Cincinnati College of Medicine, USA. LA - eng GR - T32 DK063929/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20250807 PL - England TA - J Health Psychol JT - Journal of health psychology JID - 9703616 SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - *Food Insecurity MH - *Cardiovascular Diseases MH - *Food Assistance/statistics & numerical data MH - *Feeding Behavior/psychology PMC - PMC12333545 MID - NIHMS2092118 OTO - NOTNLM OT - adolescents OT - cardiometabolic OT - food insecurity OT - loss of control eating OT - type 2 diabetes COIS- Declaration of conflicting interestsThe authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: none EDAT- 2025/08/07 06:26 MHDA- 2026/03/06 08:59 PMCR- 2025/08/08 CRDT- 2025/08/07 05:20 PHST- 2026/03/06 08:59 [medline] PHST- 2025/08/07 06:26 [pubmed] PHST- 2025/08/07 05:20 [entrez] PHST- 2025/08/08 00:00 [pmc-release] AID - 10.1177/13591053251354859 [doi] PST - ppublish SO - J Health Psychol. 2026 Mar;31(3):1192-1207. doi: 10.1177/13591053251354859. Epub 2025 Aug 7. PMID- 40771334 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250809 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 16 DP - 2025 TI - Group cohesion, motor self-efficacy, and socio-emotional skills in physical education students in a region of Spain: a descriptive study. PG - 1631231 LID - 10.3389/fpsyg.2025.1631231 [doi] LID - 1631231 AB - INTRODUCTION: Understanding the impact of physical activity, mobile device use, and sociodemographic variables on students' psychosocial development is key to promoting healthier and more inclusive educational environments. This study examined how factors such as gender, age, geographic location, PA, and mobile device use influence group cohesion, motor self-efficacy, frustration tolerance, and social skills in primary and secondary school students. METHODS: A cross-sectional design was used with a large sample of school-aged children and adolescents. The study assessed group cohesion, motor self-efficacy, frustration tolerance, and social skills through validated scales. Statistical analyses included t-tests, effect sizes (Hedges' g), Spearman correlations, and multiple linear regressions to examine relationships and predictive models across sociodemographic and behavioral variables. RESULTS: Girls scored significantly higher in assertiveness, frustration tolerance, and communication and conflict resolution skills. Rural students outperformed their urban peers across several psychosocial dimensions. Higher PA levels were associated with increased motor self-efficacy and group cohesion, particularly in boys. Excessive mobile device use correlated negatively with communication and conflict resolution skills, especially in girls. Regression analyses revealed that variables such as PA, sex, and mobile device use significantly predicted group cohesion and communication skills. Frustration tolerance and conflict resolution were notably influenced by communication skills and assertiveness, respectively. CONCLUSION: Regular engagement in physical activity and reduced mobile device use are positively associated with students' psychosocial competencies. These findings highlight the need for targeted educational interventions that consider students' age, gender, and behavioral habits. CI - Copyright (c) 2025 Garcia-Guillen, Castillo-Paredes, Galan-Arroyo and Rojo-Ramos. FAU - Garcia-Guillen, Maria Jose AU - Garcia-Guillen MJ AD - Promoting a Healthy Society Research Group (PHeSO), Faculty of Sport Sciences, University of Extremadura, Caceres, Spain. FAU - Castillo-Paredes, Antonio AU - Castillo-Paredes A AD - Grupo AFySE, Investigacion en Actividad Fisica y Salud Escolar, Escuela de Pedagogia en Educacion Fisica, Facultad de Educacion, Universidad de Las Americas, Santiago, Chile. FAU - Galan-Arroyo, Carmen AU - Galan-Arroyo C AD - BioErgon Research Group, Faculty of Sport Sciences, University of Extremadura, Caceres, Spain. FAU - Rojo-Ramos, Jorge AU - Rojo-Ramos J AD - Promoting a Healthy Society Research Group (PHeSO), Faculty of Sport Sciences, University of Extremadura, Caceres, Spain. LA - eng PT - Journal Article DEP - 20250723 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC12325365 OTO - NOTNLM OT - frustration tolerance OT - group cohesion OT - motor self-efficacy OT - physical activity OT - social skills COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/08/07 11:43 MHDA- 2025/08/07 11:44 PMCR- 2025/07/23 CRDT- 2025/08/07 04:58 PHST- 2025/05/19 00:00 [received] PHST- 2025/07/01 00:00 [accepted] PHST- 2025/08/07 11:44 [medline] PHST- 2025/08/07 11:43 [pubmed] PHST- 2025/08/07 04:58 [entrez] PHST- 2025/07/23 00:00 [pmc-release] AID - 10.3389/fpsyg.2025.1631231 [doi] PST - epublish SO - Front Psychol. 2025 Jul 23;16:1631231. doi: 10.3389/fpsyg.2025.1631231. eCollection 2025. PMID- 40771271 OWN - NLM STAT- MEDLINE DCOM- 20250807 LR - 20250809 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 16 DP - 2025 TI - Association between menopause-related symptoms and muscle mass index among perimenopausal and postmenopausal women and the mediating role of estrogen levels. PG - 1628612 LID - 10.3389/fendo.2025.1628612 [doi] LID - 1628612 AB - BACKGROUND: The decline in muscle mass is a common concern among perimenopausal women. However, the association between menopause-related symptoms and muscle mass remains inconclusive, and the mechanistic role of estrogen is still unclear. METHODS: The study included 407 peri- and postmenopausal women aged 40-60 years who visited the International Peace Maternity and Child Health Hospital. Menopausal symptoms were assessed using the modified Kupperman Index (KMI). Muscle mass was evaluated using the InBody 270 analyzer, and sex hormone levels were determined by chemiluminescent immunoassay. Multiple linear regression and Mediation analysis were conducted to examine the association of KMI with MMI and the mediation of estrogen. RESULTS: A total of 407 valid cases were collected. The mean age of the patients was 49.96 +/- 3.25 years, with an average body weight of 58.02 +/- 7.36 kg and an average BMI of 22.50 +/- 2.61 kg/m(2). The findings showed that advanced age, lower education level, and reduced muscle mass index (MMI) were linked to elevated KMI scores (p<0.05). Patients with hypertension had higher KMI scores (p<0.05). Additionally, decreased estradiol (E(2)) levels correlated with heightened menopausal symptoms (p<0.05). After controlling for confounding factors such as age, educational level, menopausal stage, history of hypertension, follicle-stimulating hormone (FSH), and E(2), KMI was negatively correlated with MMI (beta=-1.612, 95% CI: -2.677 to -0.546, p=0.003). Specifically, for each unit increase in MMI, KMI decreased by 1.612 points (R(2)=0.186, p=0.003). Stratified analysis showed that the negative correlation between KMI and MMI was significant only in premenopausal women. Both the direct and indirect effects of MMI and E(2) on KMI were statistically significant (p<0.01). The mediating effect of MMI on KMI through E(2) accounted for 26.9% (p=0.001). CONCLUSIONS: Lower muscle mass is associated with severe menopausal symptoms, partially mediated by estrogen. Maintaining muscle mass may alleviate symptoms, highlighting the importance of resistance training and hormone regulation in perimenopausal women. However, due to the cross-sectional nature of the study, causality cannot be inferred. Longitudinal or interventional studies are warranted to further validate these associations and explore underlying mechanisms. CI - Copyright (c) 2025 Wang, Yang, Li, Jin, Xia and Jin. FAU - Wang, Xiaoyi AU - Wang X AD - International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. AD - Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Yang, Dongjian AU - Yang D AD - International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. AD - Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Li, Jiahui AU - Li J AD - International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. AD - Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Jin, Lei AU - Jin L AD - Department of Gynecology, Shanghai Fengcheng Hospital, Shanghai, China. FAU - Xia, Shuhua AU - Xia S AD - Department of Gynecology, Shanghai Fengcheng Hospital, Shanghai, China. FAU - Jin, Furui AU - Jin F AD - International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. AD - Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. LA - eng PT - Journal Article DEP - 20250723 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Estrogens) RN - 4TI98Z838E (Estradiol) SB - IM MH - Humans MH - Female MH - Middle Aged MH - Adult MH - *Perimenopause/blood/physiology MH - *Postmenopause/blood/physiology MH - *Muscle, Skeletal/physiology MH - *Menopause/physiology/blood MH - *Estrogens/blood MH - Estradiol/blood MH - Cross-Sectional Studies MH - Body Mass Index PMC - PMC12325020 OTO - NOTNLM OT - estradiol OT - mediation OT - menopause-related symptoms OT - muscle mass index OT - peri- and post-menopause COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/08/07 06:27 MHDA- 2025/08/07 06:28 PMCR- 2025/07/23 CRDT- 2025/08/07 04:57 PHST- 2025/05/14 00:00 [received] PHST- 2025/07/07 00:00 [accepted] PHST- 2025/08/07 06:28 [medline] PHST- 2025/08/07 06:27 [pubmed] PHST- 2025/08/07 04:57 [entrez] PHST- 2025/07/23 00:00 [pmc-release] AID - 10.3389/fendo.2025.1628612 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2025 Jul 23;16:1628612. doi: 10.3389/fendo.2025.1628612. eCollection 2025. PMID- 40770699 OWN - NLM STAT- MEDLINE DCOM- 20250807 LR - 20250809 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 25 IP - 1 DP - 2025 Aug 6 TI - Development and validation of a prediction nomogram for adverse pregnancy outcomes among urban Chinese women with hypothyroxinemia during early pregnancy. PG - 821 LID - 10.1186/s12884-025-07931-3 [doi] LID - 821 AB - BACKGROUND: This study aimed to identify risk factors for adverse pregnancy outcomes (APO) in women with isolated maternal hypothyroxinemia (IMH) and to develop a nomogram for predicting APO risk during routine antenatal visits. METHODS: Data from 1254 IMH pregnancies, collected between January 2016 and December 2018 at the International Peace Maternal and Child Health Hospital (IPMCH) in Shanghai, China, were analyzed. APO, the primary outcome, included preterm birth (PTB), macrosomia, gestational diabetes mellitus (GDM), and hypertensive disorders of pregnancy (HDP). Multivariable logistic regression analyses identified risk factors for APO in IMH, and the least absolute shrinkage and selection operator (LASSO) regression algorithm was applied for feature selection, with cross-validation determining the optimal tuning parameter (lambda). A nomogram based on the multivariable logistic regression model was developed to estimate APO risk, validated using 500 bootstrap resampling and a 2019 cohort of 745 women from the same institution. Model performance was assessed using discrimination and calibration metrics. RESULTS: Among 57 features, maternal age, elevated diastolic blood pressure, a family history of hypertension or diabetes, pre-conception BMI, fasting plasma triglycerides, fasting plasma glucose, HbA1c, and monocyte counts in the first trimester were identified via LASSO regression as significant risk factors, with pre-conception BMI being the most prominent. The area under the receiver operating characteristic curve (ROC-AUC), sensitivity, specificity, PPV, NPV and F1 score were 0.73 (95% CI: 0.70-0.76), 62.09%, 72.11%, 59.03%, 74.60% and 60.49% respectively in the training cohort, and 0.72 (95% CI: 0.68-0.76), 60.01%, 72.65%, 56.15%, 75.12% and 58.01% respectively in the validation cohort. Calibration plots demonstrated good consistency between predicted and observed APO incidences, and decision curve analyses indicated a positive net clinical benefit across cohorts. CONCLUSIONS: This study presented a robust early-pregnancy predictive model for APO in IMH women, offering clinicians a valuable tool for risk assessment and the early identification of high-risk pregnancies. CI - (c) 2025. The Author(s). FAU - Zhou, Yulai AU - Zhou Y AD - School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, China. AD - Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Huang, Zixuan AU - Huang Z AD - School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, China. AD - Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Ren, Jiabin AU - Ren J AD - School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, China. FAU - Liu, Chunxiao AU - Liu C AD - School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, China. FAU - Yu, Tiantian AU - Yu T AD - School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, China. FAU - Wu, Weibin AU - Wu W AD - School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, China. wuweibin01@gmail.com. AD - Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. wuweibin01@gmail.com. FAU - Fan, Jianxia AU - Fan J AD - School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, China. fanjianxia122@126.com. AD - Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. fanjianxia122@126.com. LA - eng GR - 82271706/National Natural Science Foundation of China/ GR - 82261128001/National Natural Science Foundation of China/ GR - 2018YFC1004602/National Key R&D Program of China/ GR - SHDC12022119/Emerging Frontier Technologies in Shanghai Municipal Hospitals Joint Research Project/ PT - Journal Article PT - Validation Study DEP - 20250806 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 RN - Chinese people SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Nomograms MH - Adult MH - China/epidemiology MH - *Pregnancy Outcome/epidemiology MH - *Pregnancy Complications/epidemiology/blood MH - Risk Factors MH - Diabetes, Gestational/epidemiology MH - *Hypothyroidism/complications/epidemiology/blood MH - Pregnancy Trimester, First MH - Risk Assessment/methods MH - Urban Population/statistics & numerical data MH - Premature Birth/epidemiology MH - Logistic Models MH - Hypertension, Pregnancy-Induced/epidemiology MH - Fetal Macrosomia/epidemiology MH - East Asian People PMC - PMC12329891 OTO - NOTNLM OT - Adverse pregnancy outcomes OT - Isolated maternal hypothyroxinemia OT - Nomogram OT - Prediction model OT - Risk stratification COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). This study was approved by the medical ethical committee of IPMCH, School of Medicine, Shanghai Jiao Tong University (No. GKLW2022-29). Informed consent was obtained from all patients. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/08/07 06:26 MHDA- 2025/08/07 06:27 PMCR- 2025/08/06 CRDT- 2025/08/07 00:54 PHST- 2024/07/23 00:00 [received] PHST- 2025/07/10 00:00 [accepted] PHST- 2025/08/07 06:27 [medline] PHST- 2025/08/07 06:26 [pubmed] PHST- 2025/08/07 00:54 [entrez] PHST- 2025/08/06 00:00 [pmc-release] AID - 10.1186/s12884-025-07931-3 [pii] AID - 7931 [pii] AID - 10.1186/s12884-025-07931-3 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2025 Aug 6;25(1):821. doi: 10.1186/s12884-025-07931-3. PMID- 40767930 OWN - NLM STAT- MEDLINE DCOM- 20260906 LR - 20260909 IS - 2196-8837 (Electronic) IS - 2197-3792 (Print) IS - 2196-8837 (Linking) VI - 13 IP - 5 DP - 2026 Oct TI - Knowledge, Attitudes, and Practices Regarding Nutrition and Worm Infestation Among Parents/Guardians of Tribal Children of Udupi District: A Cross-Sectional Assessment. PG - 4370-4380 LID - 10.1007/s40615-025-02586-4 [doi] AB - BACKGROUND: The Koraga tribe, a particularly vulnerable tribal group (PVTG) in India, faces significant health disparities, especially among children. This study focussed on assessing knowledge, attitude, and practices (KAP) regarding nutrition and worm infestation among parents/guardians of Koraga tribal children aged 5 to 10 years in Udupi District. METHODS: A community-based cross-sectional study was conducted among 122 Koraga tribal households to assess the KAP among parents/guardians regarding the nutrition and worm infestation in their children aged 5 to 10 years, using a structured and validated questionnaire developed for this purpose. Descriptive statistics were used to summarize demographic characteristics, and Spearman's correlation was applied to assess associations between the study variables. Statistical tests were performed using SPSS version 20.0. RESULTS: Out of the total 122 participants, the majority (94.3%) were females, with a median age of 32 years (IQR 29-36). Most (82%) had a primary level of education, and 56.2% were mothers or female guardians with primary household responsibilities. The median KAP scores were knowledge, 25 (IQR 22-27); attitude, 46 (IQR 44-49), and practice, 23 (IQR 22-25) respectively. Significant positive correlations were found between knowledge and attitude (rho = 0.314, p < 0.05) and between knowledge and practice (rho = 0.186, p < 0.05). Socio-economic status showed positive correlations with knowledge (p < 0.05) and attitude (p < 0.05) scores, while the availability of toilet facilities was positively associated with practice scores (p < 0.05). CONCLUSION: The study revealed that parents/guardians had moderate to good KAP regarding nutrition and worm infestation. The positive correlations suggest an association between higher knowledge, improved attitudes, and better practices, although causality cannot be inferred due to the cross-sectional study design. Future interventional programs may help enhance KAP and promote sustained health benefits among Koraga tribal children. CI - (c) 2025. The Author(s). FAU - Pujari, Sowmya AU - Pujari S AD - Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. FAU - Thunga, Girish AU - Thunga G AD - Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. FAU - Shetty, Ranjitha S AU - Shetty RS AD - Centre for Indigenous Population, Department of Community Medicine, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. FAU - Mundkur, Suneel C AU - Mundkur SC AD - Department of Paediatrics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. FAU - Devi, Elsa Sanatombi AU - Devi ES AD - Department of Medical Surgical Nursing, Manipal College of Nursing, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. AD - Medical Surgical Nursing Department, Manipal College of Nursing, MANIPAL ACADEMY OF HIGHER EDUCATION, Manipal, Karnataka 576104, India. FAU - B, Unnikrishnan AU - B U AD - Department of Community Medicine, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. FAU - Nair, Sreedharan AU - Nair S AD - Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. nair.sreedhar@manipal.edu. LA - eng SI - ClinicalTrials.gov/CTRI/2023/04/051859 PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250806 PL - Switzerland TA - J Racial Ethn Health Disparities JT - Journal of racial and ethnic health disparities JID - 101628476 SB - IM MH - Humans MH - Female MH - *Health Knowledge, Attitudes, Practice/ethnology MH - Cross-Sectional Studies MH - Male MH - Child, Preschool MH - Child MH - India MH - *Parents/psychology MH - Adult MH - *Nutritional Status MH - Surveys and Questionnaires PMC - PMC13546145 OTO - NOTNLM OT - And practices (KAP) OT - Attitude OT - Knowledge OT - Koraga tribal children OT - Nutritional status OT - Worm infestation COIS- Declarations. Ethics Approval: The study was approved by the Kasturba Medical College and Kasturba Hospital Institutional Ethics Committee, Manipal (Project Approval No.: IEC - 381/2022), prior to the initiation of the study. CTRI registration was obtained on 21/04/2023 (CTRI/2023/04/051859). Consent to Participate: Written informed consent was obtained from all individual participants included in the study. Conflict of interest: The authors declare no competing interests. EDAT- 2025/08/06 12:30 MHDA- 2026/09/06 05:40 PMCR- 2025/08/06 CRDT- 2025/08/06 11:07 PHST- 2024/09/28 00:00 [received] PHST- 2025/07/25 00:00 [accepted] PHST- 2025/07/22 00:00 [revised] PHST- 2026/09/06 05:40 [medline] PHST- 2025/08/06 12:30 [pubmed] PHST- 2025/08/06 11:07 [entrez] PHST- 2025/08/06 00:00 [pmc-release] AID - 10.1007/s40615-025-02586-4 [pii] AID - 2586 [pii] AID - 10.1007/s40615-025-02586-4 [doi] PST - ppublish SO - J Racial Ethn Health Disparities. 2026 Oct;13(5):4370-4380. doi: 10.1007/s40615-025-02586-4. Epub 2025 Aug 6. PMID- 40767283 OWN - NLM STAT- MEDLINE DCOM- 20250820 LR - 20260825 IS - 2047-9980 (Electronic) IS - 2047-9980 (Linking) VI - 14 IP - 16 DP - 2025 Aug 19 TI - Screen Time Is Associated With Cardiometabolic and Cardiovascular Disease Risk in Childhood and Adolescence. PG - e041486 LID - 10.1161/JAHA.125.041486 [doi] LID - e041486 AB - BACKGROUND: Screen time in children and adolescents may be linked to cardiometabolic and cardiovascular risk. METHODS: We analyzed data from >1000 participants in the COPSAC2010 and COPSAC2000 (Copenhagen Prospective Studies on Asthma in Childhood) mother-child 2000 and 2010 cohorts. Discretionary screen time, reported by parents or self, was assessed in relation to a composite cardiometabolic risk score based on Z scores of waist circumference, systolic blood pressure, high-density lipoprotein cholesterol, triglycerides, and glucose. Secondary outcomes included insulin resistance, inflammation, lipoproteins, and anthropometry. A predicted cardiovascular risk score, derived from Cox models trained on UK Biobank data, was also assessed as an outcome. We evaluated whether lifestyle factors (sleep, physical activity, diet, puberty) moderated these associations. Blood nuclear magnetic resonance metabolomics were modeled using supervised machine learning to identify a metabolic screen-time signature. RESULTS: Each additional hour of screen time was associated with higher cardiometabolic risk in both children (beta=0.08 [0.01-0.14], P=0.021) and adolescents (beta=0.13 [0.07-0.20], P=0.001). Sleep duration significantly moderated this association in both cohorts (childhood: P=0.029; adolescence: P=0.012), with higher risk among those with shorter sleep. Screen time was also associated with higher predicted cardiovascular risk in adolescence (beta=0.07 [0.01-0.13], P=0.017). A screen time-associated metabolomic signature identified in childhood was validated in adolescence (beta=0.14 [0.03-0.26], P=0.014). CONCLUSIONS: Screen time was positively associated with cardiometabolic and cardiovascular risk, and these associations were stronger among children and adolescents with shorter sleep duration. These findings highlight the importance of jointly considering screen time and sleep patterns in the assessment of early-life risk factors for cardiometabolic and cardiovascular health. FAU - Horner, David AU - Horner D AUID- ORCID: 0000-0002-0200-4561 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood Herlev and Gentofte Hospital, University of Copenhagen Denmark. FAU - Jahn, Marie AU - Jahn M AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood Herlev and Gentofte Hospital, University of Copenhagen Denmark. FAU - Bonnelykke, Klaus AU - Bonnelykke K AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood Herlev and Gentofte Hospital, University of Copenhagen Denmark. FAU - Chawes, Bo AU - Chawes B AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood Herlev and Gentofte Hospital, University of Copenhagen Denmark. FAU - Flensborg-Madsen, Trine AU - Flensborg-Madsen T AUID- ORCID: 0000-0002-6753-335X AD - Unit of Medical Psychology, Department of Public Health University of Copenhagen Denmark. AD - National Institute of Public Health University of Southern Denmark Copenhagen Denmark. FAU - Schoos, Ann-Marie Malby AU - Schoos AM AUID- ORCID: 0000-0002-5827-0885 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood Herlev and Gentofte Hospital, University of Copenhagen Denmark. AD - Department of Pediatrics Slagelse Hospital Slagelse Denmark. FAU - Stokholm, Jakob AU - Stokholm J AUID- ORCID: 0000-0003-4989-9769 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood Herlev and Gentofte Hospital, University of Copenhagen Denmark. AD - Department of Pediatrics Slagelse Hospital Slagelse Denmark. AD - Department of Food Science, Section of Food Microbiology and Fermentation University of Copenhagen Denmark. FAU - Rasmussen, Morten Arendt AU - Rasmussen MA AUID- ORCID: 0000-0001-7431-5206 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood Herlev and Gentofte Hospital, University of Copenhagen Denmark. AD - Department of Food Science, Section of Food Microbiology and Fermentation University of Copenhagen Denmark. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250806 PL - England TA - J Am Heart Assoc JT - Journal of the American Heart Association JID - 101580524 RN - 0 (Blood Glucose) SB - IM MH - Humans MH - Adolescent MH - Child MH - Female MH - Male MH - *Screen Time MH - *Cardiovascular Diseases/epidemiology/etiology/diagnosis/blood MH - Risk Assessment MH - Cardiometabolic Risk Factors MH - Sleep MH - Prospective Studies MH - Time Factors MH - Risk Factors MH - Blood Glucose PMC - PMC12533741 OTO - NOTNLM OT - adolescence OT - cardiometabolic risk OT - metabolomics OT - screen time OT - sleep COIS- None. EDAT- 2025/08/06 12:30 MHDA- 2025/08/20 06:32 PMCR- 2025/08/06 CRDT- 2025/08/06 06:53 PHST- 2025/08/20 06:32 [medline] PHST- 2025/08/06 12:30 [pubmed] PHST- 2025/08/06 06:53 [entrez] PHST- 2025/08/06 00:00 [pmc-release] AID - JAH311166 [pii] AID - 10.1161/JAHA.125.041486 [doi] PST - ppublish SO - J Am Heart Assoc. 2025 Aug 19;14(16):e041486. doi: 10.1161/JAHA.125.041486. Epub 2025 Aug 6. PMID- 40765160 OWN - NLM STAT- MEDLINE DCOM- 20260829 LR - 20260829 IS - 1754-9515 (Electronic) IS - 1754-9507 (Linking) VI - 28 IP - 4 DP - 2026 Aug TI - A systematic review of clinical assessment tools that evaluate the feeding skills domain for paediatric feeding disorder. PG - 652-662 LID - 10.1080/17549507.2025.2538617 [doi] AB - PURPOSE: There is limited evidence regarding which clinical assessment tools are best utilised to assess feeding skills in Paediatric Feeding Disorder. This systematic review aimed to identify and assess the quality of clinical assessment tools designed to measure feeding skills. METHOD: A search was conducted (up to 31 July 2023). Assessment tools were included if they: (a) targeted the feeding skills domain for Paediatric Feeding Disorder; and (b) were appropriate for children >6 months-18 years. Psychometric properties for each tool were extracted and assessed using the COnsensus-based Standards for the Selection of health Measurement INstruments (COSMIN) checklist. RESULT: In total, 12 clinical assessment tools were reviewed across 19 studies. These tools were found to be appropriate for a wide age range, of variable length, and mostly freely available. Variable methodological quality was observed, with most tools demonstrating adequate reliability but having limited information on validity. None of the reviewed tools used testing to demonstrate whether the tool could capture change over time. CONCLUSION: There are limited clinical assessment tools available to measure paediatric feeding skills, and none of the reviewed tools demonstrated sensitivity to change in function over time. No tool was suitable for universal application in children with Paediatric Feeding Disorder. FAU - Marshall, Jeanne AU - Marshall J AD - Speech Pathology Department, Queensland Children's Hospital, Children's Health Queensland Hospital and Health Service, Brisbane, Australia. AD - School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia. FAU - Gosa, Memorie M AU - Gosa MM AD - Department of Communicative Disorders, The University of Alabama, Tuscaloosa, Alabama, USA. FAU - Dodrill, Pamela AU - Dodrill P AD - Newborn Medicine Department, Brigham and Women's Hospital, Boston, Massachusetts, USA. AD - Newborn Medicine Department, Harvard Medical School, Boston, Massachusetts, USA. LA - eng PT - Journal Article PT - Systematic Review DEP - 20250805 PL - England TA - Int J Speech Lang Pathol JT - International journal of speech-language pathology JID - 101320232 SB - IM MH - Humans MH - Child MH - Psychometrics MH - Reproducibility of Results MH - Child, Preschool MH - *Feeding and Eating Disorders of Childhood/diagnosis MH - Infant MH - *Feeding Behavior MH - Adolescent OTO - NOTNLM OT - clinical assessment tools OT - deglutition disorder OT - feeding and eating disorders of childhood OT - paediatric OT - patient outcome assessment OT - psychometrics EDAT- 2025/08/06 06:28 MHDA- 2026/08/29 17:36 CRDT- 2025/08/06 01:43 PHST- 2026/08/29 17:36 [medline] PHST- 2025/08/06 06:28 [pubmed] PHST- 2025/08/06 01:43 [entrez] AID - 10.1080/17549507.2025.2538617 [doi] PST - ppublish SO - Int J Speech Lang Pathol. 2026 Aug;28(4):652-662. doi: 10.1080/17549507.2025.2538617. Epub 2025 Aug 5. PMID- 40765073 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250809 IS - 2733-7545 (Electronic) IS - 2733-7545 (Linking) VI - 29 IP - 2 DP - 2025 Jun TI - Improving body composition and social function through combined exercise program in children with intellectual disabilities: a single-arm pre-post intervention study. PG - 62-69 LID - 10.20463/pan.2025.0015 [doi] AB - PURPOSE: Although children with intellectual disabilities (ID) face a heightened risk of physical inactivity, psychiatric comorbidities such as ADHD, and delayed social development -which collectively impair their physical, cognitive, and emotional well-being- and structured physical activity (PA) has been proposed as a multidimensional intervention, few studies have rigorously examined the integrated effects of a combined exercise program on the physical health, behavioral symptoms, and social functioning of this population. This study aimed to evaluate the effects of a 16-week combined exercise program -incorporating aerobic and resistance training- on body composition, ADHD-related behavioral symptoms, and social functioning in children with ID. METHODS: A total of 30 children with mild ID (mean age: 10.4 +/- 1.3 years) participated in a structured intervention comprising three 60-min exercise sessions per week over 16 weeks. The exercise intensity progressively increased across three phases (50-80% HRR). Body composition (including BMI, body fat, and muscle mass) was assessed using validated anthropometric and bioelectrical impedance methods. ADHD symptoms were evaluated using the ADHD Rating Scale-IV, and social functioning was assessed using the Social Maturity Scale, which were rated by both parents and teachers. Paired t-tests were conducted to assess pre-post differences, with significance set at p < 0.05. RESULTS: Postintervention results revealed significant improvements in children's body composition: reductions in weight (-3.1%, p = 0.031), BMI (-3.3%, p = 0.028), body fat (-6.3%, p = 0.015), waist circumference (-2.6%, p = 0.040), hip circumference (-1.4%, p = 0.048), and WHR (-1.1%, p = 0.045), along with an increase in muscle mass (+5.9%, p = 0.022). ADHD-related symptoms significantly decreased: inattention (-20.0%, p = 0.012), hyperactivity/impulsivity (-20.5%, p = 0.014), and task incompletion (-20.7%, p = 0.010). Social indicators also improved, including reductions in both social interaction difficulties (-20.3%, p = 0.020) and repetitive behavior (-20.0%, p = 0.025). CONCLUSION: The 16-week combined exercise program produced meaningful improvements in the physical health, attentional control, and social functioning of children with ID. These findings underscore the utility of integrated PA as a nonpharmacological, multidomain intervention to enhance the well-being of neurodiverse children. Future studies should explore the underlying neurobiological mechanisms and assess the long-term sustainability of these outcomes. FAU - Oh, Siyeon AU - Oh S AD - College of Art and Physical Education, Chosun University, Gwangju, Republic of Korea. FAU - Son, Woo-Hyeon AU - Son WH AD - Design Institute, Inje University, Gimhae, Republic of Korea. FAU - Ha, Min-Seong AU - Ha MS AD - Department of Sport Science, College of Arts and Sports, University of Seoul, Seoul, Republic of Korea. LA - eng GR - Ministry of Education/ GR - 2022S1A5B5A17046535/National Research Foundation of Korea/ PT - Journal Article DEP - 20250630 PL - Korea (South) TA - Phys Act Nutr JT - Physical activity and nutrition JID - 101770644 PMC - PMC12325873 OTO - NOTNLM OT - adhd symptoms OT - body composition OT - combined exercise OT - developmental disabilities OT - intellectual disability OT - physical activity intervention OT - social functioning EDAT- 2025/08/06 06:28 MHDA- 2025/08/06 06:29 PMCR- 2025/06/01 CRDT- 2025/08/06 01:18 PHST- 2025/02/04 00:00 [received] PHST- 2025/06/03 00:00 [accepted] PHST- 2025/08/06 06:29 [medline] PHST- 2025/08/06 06:28 [pubmed] PHST- 2025/08/06 01:18 [entrez] PHST- 2025/06/01 00:00 [pmc-release] AID - pan.2025.0015 [pii] AID - pan-2025-0015 [pii] AID - 10.20463/pan.2025.0015 [doi] PST - ppublish SO - Phys Act Nutr. 2025 Jun;29(2):62-69. doi: 10.20463/pan.2025.0015. Epub 2025 Jun 30. PMID- 40760063 OWN - NLM STAT- MEDLINE DCOM- 20250805 LR - 20250808 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Aug 4 TI - Diagnostic performance of MUAC and MUACZ in screening acute malnutrition among children aged 6-23 months in Amhara Region, Ethiopia. PG - 28374 LID - 10.1038/s41598-024-82294-x [doi] LID - 28374 AB - Mid-Upper Arm Circumference (MUAC), Mid-Upper Arm Circumference-for-Age Z-Score (MUACZ), or Weight-for-Length Z-Score (WHZ) are used to screen for acute malnutrition in children. Studies conducted in various countries, including Ethiopia, have indicated variability in the agreement between these assessments at the World Health Organization recommended cutoffs across different ethnic groups with varying body frames. The low sensitivity of MUAC at standard cutoffs has important implications for program effectiveness. Therefore, this study aimed to validate the diagnostic performance of MUAC and MUACZ in screening for acute malnutrition among children aged 6-23 months in Ethiopia. A community-based cross-sectional study was conducted on 457 randomly selected children aged 6-23 months in the Amhara Region, Ethiopia, from February 2-18, 2023. The Spearman's rank correlation test, Cohen's kappa statistics, and Receiver Operating Curve analysis were conducted. The optimal cutoff points for MUAC and MUACZ were determined by selecting the points that maximized the Youden index. Statistical significance was determined with a p-value < 0.05, using a 95% confidence interval. MUAC, MUACZ, and WHZ results revealed that 11.0%, 8.6%, and 13.2% of children were wasted, respectively, and the percentage of misclassification in screening acute malnutrition was approximately 16%. MUAC and MUACZ had low sensitivity but high specificity in screening for acute malnutrition. MUAC and MUACZ showed poor correlation with WHZ when screening subjects for acute malnutrition using the World Health Organization standard cutoffs. In the Receiver Operating Characteristics curve analysis, significant predictive ability was only observed with MUAC when screening global acute malnutrition cases, and it showed a poor predictive ability (AUC = 0.61, 95% CI: 0.53, 0.70) (p < 0.001). The Youden index statistics revealed that the optimal cutoff for MUAC and MUACZ to define global acute malnutrition at WHZ < -2 SD was 13.6 cm and -0.43 SD, respectively. In addition, the optimal cutoffs for diagnosing severe acute malnutrition in children with WHZ of < -3 SD were found to be 13.1 cm and -1.91 SD for MUAC and MUACZ, respectively. The optimal cutoff values also vary in sex and age categories. Both MUAC and MUACZ had poor performance in screening acute malnutrition, and a significant proportion of children were missed despite they were wasted as compared to WHZ at the standard cutoffs. The optimal cutoff levels differ for different age and sex categories. This may affect admission and discharge rates and have a significant impact on children's health. Modifications in the standard cutoffs are needed to ensure the quality of acute malnutrition screening and treatment services. CI - (c) 2024. The Author(s). FAU - Menber, Yonatan AU - Menber Y AD - Department of Nutrition and Dietetics, School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar City, Ethiopia. nataniem21@gmail.com. FAU - Belachew, Tefera AU - Belachew T AD - Department of Nutrition and Dietetics, Faculty of Public Health, College of Public Health, Jimma University, Jimma City, Ethiopia. FAU - Fentahun, Netsanet AU - Fentahun N AD - Department of Nutrition and Dietetics, School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar City, Ethiopia. LA - eng PT - Journal Article DEP - 20250804 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Infant MH - Ethiopia/epidemiology MH - Female MH - Male MH - Cross-Sectional Studies MH - *Arm/anatomy & histology MH - *Mass Screening/methods MH - *Malnutrition/diagnosis/epidemiology MH - *Anthropometry/methods MH - ROC Curve PMC - PMC12322050 OTO - NOTNLM OT - Acute malnutrition OT - Children OT - Ethiopia OT - MUAC OT - Validation OT - WHZ COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/08/05 00:29 MHDA- 2025/08/05 06:28 PMCR- 2025/08/04 CRDT- 2025/08/04 23:41 PHST- 2024/08/26 00:00 [received] PHST- 2024/12/04 00:00 [accepted] PHST- 2025/08/05 06:28 [medline] PHST- 2025/08/05 00:29 [pubmed] PHST- 2025/08/04 23:41 [entrez] PHST- 2025/08/04 00:00 [pmc-release] AID - 10.1038/s41598-024-82294-x [pii] AID - 82294 [pii] AID - 10.1038/s41598-024-82294-x [doi] PST - epublish SO - Sci Rep. 2025 Aug 4;15(1):28374. doi: 10.1038/s41598-024-82294-x. PMID- 40759827 OWN - NLM STAT- MEDLINE DCOM- 20250804 LR - 20250807 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 30 IP - 1 DP - 2025 Aug 4 TI - The interaction between problematic internet use, diet quality, and disordered eating risk in adolescents: a mediation and network analysis. PG - 61 LID - 10.1007/s40519-025-01774-9 [doi] LID - 61 AB - BACKGROUND: Adolescence is a key period for problematic internet use (PIU) and disordered eating (DE), with prior studies linking them, but the role of diet quality unclear. OBJECTIVE: This study aimed to investigate the relationships between PIU, diet quality, and DE in adolescents using mediator and network analyses, with a specific focus on the mediating role of diet quality. METHODS: A cross-sectional study was conducted with 647 high-school students in Erzurum, Turkey. Data were collected through validated instruments, including the Young Internet Addiction Test, Social Media Addiction Scale, KIDMED Mediterranean Diet Quality Index, and Eating Attitudes Test (EAT-26). Statistical analyses included mediation modeling and network analysis (NA). RESULTS: The prevalence of DE risk was 18.2%, while 27% of participants met the criteria for social media addiction. Additionally, 3.6% were classified as at potential risk for internet addiction. In addition to PIU and social media addiction, higher maternal education levels were also significantly associated with greater DE risk (p < 0.05). Mediation analysis showed that problematic internet use was linked to lower adherence to the Mediterranean diet (beta = -0.12, p = 0.002), which was associated with higher DE risk (beta = 0.15, p < 0.001). The indirect effect was significant (beta = -0.02, p = 0.016), supporting partial mediation. NA identified internet addiction as the central node, linking DE risk, social media disorder, and diet quality. CONCLUSION: Internet addiction is linked to increased DE risk, mediated by diet quality, highlighting the need to address it in adolescent interventions. Longitudinal studies are needed. LEVEL EVIDENCE V: Evidence obtained from a cross-sectional descriptive study. CI - (c) 2025. The Author(s). FAU - Aydin Cil, Mevra AU - Aydin Cil M AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Ataturk University, Erzurum, Turkey. FAU - Carikci, Sumeyye AU - Carikci S AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Ataturk University, Erzurum, Turkey. FAU - Foroudi Pourdeh, Elham AU - Foroudi Pourdeh E AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Ataturk University, Erzurum, Turkey. FAU - Jahrami, Haitham AU - Jahrami H AD - Department of Psychiatry, College of Medicine and Health Sciences, Arabian Gulf University, Manama, Bahrain. haitham.jahrami@outlook.com. AD - Government Hospitals, Manama, Bahrain. haitham.jahrami@outlook.com. LA - eng PT - Journal Article DEP - 20250804 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - Adolescent MH - Female MH - Cross-Sectional Studies MH - Male MH - *Feeding and Eating Disorders/epidemiology/psychology MH - *Internet Addiction Disorder/epidemiology/psychology MH - Turkey/epidemiology MH - Mediation Analysis MH - *Adolescent Behavior/psychology MH - *Diet MH - Risk Factors MH - Diet, Mediterranean MH - Social Media MH - *Behavior, Addictive MH - *Internet Use MH - *Feeding Behavior/psychology PMC - PMC12321680 OTO - NOTNLM OT - Adolescents OT - Diet quality OT - Disordered eating (DE) OT - Internet addiction OT - Problematic internet use (PIU) OT - Social media addiction COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the principles of Helsinki Declaration, and it was reviewed and approved by the Ataturk University Faculty of Health Sciences Ethics Committee (Approval No.: [2022/03/04]). March 04, 2022). This study is by the relevant guidelines and regulations. The data in this study were obtained from this patient and his legal guardian. Written informed consent was obtained from the adolescent's parents. Informed consent was obtained from the adolescent's parents and/or legal guardians for the publication of identifying information/images in online open access publications. Consent for publication: Not applicable. Competing interest:: The authors declare no competing interests. EDAT- 2025/08/05 00:30 MHDA- 2025/08/05 00:31 PMCR- 2025/08/04 CRDT- 2025/08/04 23:27 PHST- 2024/12/03 00:00 [received] PHST- 2025/07/23 00:00 [accepted] PHST- 2025/08/05 00:31 [medline] PHST- 2025/08/05 00:30 [pubmed] PHST- 2025/08/04 23:27 [entrez] PHST- 2025/08/04 00:00 [pmc-release] AID - 10.1007/s40519-025-01774-9 [pii] AID - 1774 [pii] AID - 10.1007/s40519-025-01774-9 [doi] PST - epublish SO - Eat Weight Disord. 2025 Aug 4;30(1):61. doi: 10.1007/s40519-025-01774-9. PMID- 40759813 OWN - NLM STAT- MEDLINE DCOM- 20251201 LR - 20261010 IS - 1557-1920 (Electronic) IS - 1557-1912 (Linking) VI - 27 IP - 6 DP - 2025 Dec TI - Health-Related Education for New Immigrants to Prevent Chronic Diseases: A Systematic Review. PG - 1074-1089 LID - 10.1007/s10903-025-01737-3 [doi] AB - Cardiovascular diseases (CVD) and cancers are chronic, often preventable diseases that remain the leading causes of mortality and morbidity globally. Immigrants are at higher risk of developing CVD and cancers, therefore, and it is important to understand the effectiveness of health-related education targeted to this group to improve knowledge, attitudes, and behaviours related to chronic disease prevention. The objective of this systematic review is to examine the effectiveness of health-related education delivered to new immigrants to western countries at improving knowledge, attitudes, and health behaviours to prevent chronic disease. A systematic review was carried out using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Literature was searched using Medline, Embase, Emcare, Global Health, and Google Scholar was used to identify grey literature. Each database was searched from its inception through April 16th, 2024. A narrative synthesis was completed. Appropriate validated tools were utilized to assess the methodological quality of each study. A comprehensive assessment of study quality was undertaken for all the studies using the QUaDS tool. A total of 11 studies were included in the review, which included quantitative, qualitative and mixed-method studies. The 11 studies included 1,212 participants with age range from 18-75 years of age. The studies included changes in knowledge, (deeper understanding of food and health, recipes to cook traditional foods with healthier recipes, diabetes prevention strategies), behaviours (an increase in weekly step count, reading food labels when doing grocery shopping, purchasing food based on nutritional quality, eliminating unhealthy foods, consumption of more fruits and vegetables, quitting smoking, and improved sleep behaviours). Several methodological limitations of the included studies were identified. This review highlights that the use of behaviour change theories can assist clinicians better understand behaviour change and at the same time inform the development of evidence-based interventions. Given the significant burden of chronic diseases in immigrant populations, it is imperative that health-related education programs are made available, and immigrant populations are informed and valued at each phase of the program. Tailored approaches, for example, story-telling, in-class instructions, healthy heart melas (community gatherings), video and pictorial illustrations have been found to be particularly effective. CI - (c) 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Hemani, Salima AU - Hemani S AD - Faculty of Health Disciplines, Athabasca University, Athabasca, Canada. FAU - Sansanwal, Sohnia AU - Sansanwal S AD - Mary Heersink School of Global Health and Social Medicine, McMaster University, Hamilton, Canada. FAU - de Souza, Russell AU - de Souza R AD - Mary Heersink School of Global Health and Social Medicine, McMaster University, Hamilton, Canada. AD - Population Health Research Institute, Hamilton Health Sciences Corporation, Hamilton, Canada. AD - Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada. FAU - Banfield, Laura AU - Banfield L AD - Mary Heersink School of Global Health and Social Medicine, McMaster University, Hamilton, Canada. AD - Health Sciences Library, McMaster University, Hamilton, Canada. FAU - Anand, Sonia AU - Anand S AD - Mary Heersink School of Global Health and Social Medicine, McMaster University, Hamilton, Canada. anands@mcmaster.ca. AD - Population Health Research Institute, Hamilton Health Sciences Corporation, Hamilton, Canada. anands@mcmaster.ca. AD - Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada. anands@mcmaster.ca. AD - Department of Medicine, McMaster University, Hamilton, Ontario, Canada. anands@mcmaster.ca. LA - eng GR - 2223-HQ-000007/Public Health Agency of Canada/ PT - Journal Article PT - Systematic Review DEP - 20250804 PL - United States TA - J Immigr Minor Health JT - Journal of immigrant and minority health JID - 101256527 SB - IM MH - Humans MH - Chronic Disease/prevention & control/ethnology MH - *Emigrants and Immigrants/education MH - *Health Education/organization & administration MH - Health Knowledge, Attitudes, Practice MH - Health Behavior MH - Adult MH - Middle Aged MH - Aged MH - Adolescent COIS- Declarations. Competing Interests: The authors declare no competing interests. EDAT- 2025/08/05 00:29 MHDA- 2025/12/01 12:27 CRDT- 2025/08/04 23:26 PHST- 2025/07/04 00:00 [accepted] PHST- 2025/12/01 12:27 [medline] PHST- 2025/08/05 00:29 [pubmed] PHST- 2025/08/04 23:26 [entrez] AID - 10.1007/s10903-025-01737-3 [pii] AID - 10.1007/s10903-025-01737-3 [doi] PST - ppublish SO - J Immigr Minor Health. 2025 Dec;27(6):1074-1089. doi: 10.1007/s10903-025-01737-3. Epub 2025 Aug 4. PMID- 40756388 OWN - NLM STAT- MEDLINE DCOM- 20250804 LR - 20250806 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Daily meal frequency and its associated factors among children aged 6-23 months in Ethiopia: a Bayesian hierarchical Poisson model. PG - 1563392 LID - 10.3389/fpubh.2025.1563392 [doi] LID - 1563392 AB - BACKGROUND: Inadequate feeding frequency during the early childhood period is responsible for more than two-thirds of global child deaths. Evidence on the rate of daily meal frequency among infants and young children at the national level is crucial for developing targeted interventions to improve feeding practices. Hence, this study aimed to identify factors associated with the rate of daily meal frequency (DMF) among children aged 6-23 months in Ethiopia. METHODS: We retrieved secondary data from the Kids record (KR) of the Ethiopian Mini Demographic and Health Survey (MDHS) dataset. A total of 1,264 children aged 6-23 months were included in the study. A Bayesian hierarchical Poisson model was employed. Model convergence was checked via Rhat, effective sample size, density plots, terrace plots, and autocorrelation plots, and all the results were confirmed. We used the widely applicable information criterion (WAIC) and leave-one-out cross-validation (LOO) for model comparison. The model parameters were estimated via special Markov chain Monte Carlo (MCMC) simulation techniques called Hamiltonian Monte Carlo (HMC) and its extension, the no-U-turn sampler (NUTS). An adjusted incidence rate ratio (AIRR) with a 95% credible interval (CrI) in the multivariable model was used to select variables that had a significant association with the rate of daily meal frequency. The data were analyzed via R software version 4.3.1. RESULTS: The mean and standard deviation of the DMF were 3.36 and 1.60, respectively. The rate of DMF was 1.17 times greater (AIRR = 1.17, 95% CrI: 0.997, 1.381) in children whose mothers had a secondary/higher educational level than in those whose mothers had no education. Kids currently being breastfed have a lower rate of DMF (AIRR = 0.88, 95% CI: 0.798, 0.979) by 10% than those who are not currently breastfeeding. Compared with children between the ages of 6-8 months, those between 9 and 11 months (AIRR = 1.55 95% CrI: 1.374, 1.754), 12-17 months (AIRR = 1.72, 95% CrI: 1.543, 1.911), and 18-23 months (AIRR = 95% CrI: 1.90, 1.692, 2.125) had 55, 72 and 90% higher rates of DMF, respectively. In the Afar region (IRR = 0.77, 95% CI: 0.615, 0.982), Somalia (AIRR = 0.83, 95% CrI: 0.682, 1.01), Benishangul (AIRR = 0.8, 95% CrI: 0.639, 0.994), Southern nation nationality and people's region (SNNPR) (AIRR = 0.73, 95% CrI: 0.596, 0.894), and (AIRR = 0.73, 95% CrI: 0.572, 0.925) decrease the daily meal frequency by 33, 17, 20, 27 and 27%, respectively, compared with that of children from Tigray. CONCLUSION AND RECOMMENDATION: The rate of DMF was low in Ethiopia and exhibited a significant clustering pattern across the country. These findings stress the need for tailored interventions addressing regional inequities, promoting age-specific nutrition, supporting maternal education, and empowering working women to improve children's nutritional intake and ensure more equitable access to meals across Ethiopia. CI - Copyright (c) 2025 Asgedom, Mohammed and Anbesu. FAU - Asgedom, Dejen Kahsay AU - Asgedom DK AD - Department of Public Health, College of Medicine and Health Sciences, Samara University, Samara, Ethiopia. FAU - Mohammed, Ausman Ahmed AU - Mohammed AA AD - Department of Nursing, College of Medicine and Health Sciences, Samara University, Samara, Ethiopia. FAU - Anbesu, Etsay Woldu AU - Anbesu EW AD - Department of Public Health, College of Medicine and Health Sciences, Samara University, Samara, Ethiopia. LA - eng PT - Journal Article DEP - 20250718 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Ethiopia MH - Infant MH - Bayes Theorem MH - Female MH - Male MH - *Meals MH - Poisson Distribution MH - *Feeding Behavior PMC - PMC12315115 OTO - NOTNLM OT - Bayesian hierarchical model OT - Ethiopia OT - associated factors OT - children 6-23 months OT - daily meal frequency COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/08/04 12:27 MHDA- 2025/08/04 12:28 PMCR- 2025/07/18 CRDT- 2025/08/04 06:12 PHST- 2025/02/06 00:00 [received] PHST- 2025/06/30 00:00 [accepted] PHST- 2025/08/04 12:28 [medline] PHST- 2025/08/04 12:27 [pubmed] PHST- 2025/08/04 06:12 [entrez] PHST- 2025/07/18 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1563392 [doi] PST - epublish SO - Front Public Health. 2025 Jul 18;13:1563392. doi: 10.3389/fpubh.2025.1563392. eCollection 2025. PMID- 40753204 OWN - NLM STAT- MEDLINE DCOM- 20250802 LR - 20250806 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Aug 2 TI - Motivation to practice health-oriented physical activity: a comparative study among university students from three countries with different cultures. PG - 2626 LID - 10.1186/s12889-025-23781-2 [doi] LID - 2626 AB - BACKGROUND: Previous research has shown the importance of motivation in promoting sustained physical activity, but the impact of cultural and geographical differences on motivational profiles remains underexplored. This study aims to address this gap by comparing motivations for engaging in health-oriented physical activity across three countries on different continents. METHODS: Following STROBE guidelines, a cross-sectional study was conducted using a stratified sampling method across three countries, yielding 1,252 respondents: 422 from Mexico, 405 from Saudi Arabia, and 425 from Spain. Participants were college students aged 18-25 years. The Motivation Scale Towards Health-Oriented Physical Activity (EMAPS), validated for the Spanish population, was used for data collection. Data integrity was ensured through response verification and addressing flagged entries. RESULTS: Identified regulation and intrinsic motivation were the most prevalent types of motivation across all three countries. All countries shared high scores in identified regulation, but cultural differences were evident. Mexico showed higher levels of self-determined regulation, while Spain and Saudi Arabia exhibited more introjected regulation and amotivation, reflecting distinct motivational profiles. CONCLUSION: Despite cultural differences, common motivational patterns for physical activity were identified, emphasizing the universal value of health and well-being goals. Mexico's motivational profile aligns closely with Self-Determination Theory (SDT), highlighting a predominantly self-determined structure with reduced external influence. Conversely, Spain and Saudi Arabia displayed stronger internalization of external pressures. These findings underscore the importance of culturally tailored interventions to promote physical activity, adapting motivational strategies to specific cultural contexts to foster long-term engagement and adherence. TRIAL REGISTRATION: The study was approved by the Institutional Review Board of Prince Sultan University (PSU IRB2023110167). CI - (c) 2025. The Author(s). FAU - Prieto-Gonzalez, Pablo AU - Prieto-Gonzalez P AD - Sport Sciences and Diagnostics Research Group, GSD-HPE Department, Prince Sultan University, Riyadh, Saudi Arabia. pprieto@psu.edu.sa. FAU - Rivera-Villafuerte, Ausel AU - Rivera-Villafuerte A AD - Innovacion en Educacion y Deporte A.C, Ciudad de Mexico, Mexico. FAU - Canli, Umut AU - Canli U AD - Faculty of Sports Sciences, Tekirdag Namik Kemal University, Tekirdag, Turkiye, Turkey. LA - eng PT - Comparative Study PT - Journal Article DEP - 20250802 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - *Motivation MH - *Students/psychology/statistics & numerical data MH - Male MH - Cross-Sectional Studies MH - Female MH - Universities MH - Saudi Arabia MH - Young Adult MH - Adolescent MH - Adult MH - *Cross-Cultural Comparison MH - *Exercise/psychology MH - Spain MH - Mexico MH - Surveys and Questionnaires PMC - PMC12317563 OTO - NOTNLM OT - College students OT - Extrinsic motivation OT - Health-Oriented physical activity OT - Intrinsic motivation OT - Motivational profiles OT - Physical activity adherence OT - Self-Determination theory COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Institutional Review Board of Prince Sultan University (PSU IRB-2023-11-0167). Informed consent was obtained from all participants before data collection, ensuring that they were aware of the study's purpose, procedures, and their right to withdraw at any time. The research adhered to ethical guidelines and principles, safeguarding the privacy and confidentiality of participants throughout the study. For the data collected in Spain and Mexico, we consulted with the relevant regulatory frameworks. In Mexico, based on the Mexican Official Standard NOM-012-SSA3-2012, ethical approval is required for biomedical or health-related research involving clinical interventions or sensitive personal data. As our study was anonymous, non-invasive, and involved no sensitive data, ethical review was not required. In Spain, the data collection was conducted independently by the first author, without the involvement of any Spanish institution. According to Spanish legislation (Ley 14/2007 de Investigacion Biomedica), ethical approval is required only for biomedical research involving risk, clinical procedures, or identifiable personal data. Given that the study involved anonymous survey responses from adult university students and posed no risk to participants, it was exempt from formal ethics committee review. Consent for publication: All participants provided written consent for their data to be published in academic journals. Consent for publication was obtained separately from consent to participate, ensuring that participants were aware of and agreed to the use of their data in scholarly dissemination. Competing interests: The authors declare no competing interests. EDAT- 2025/08/03 03:46 MHDA- 2025/08/03 03:47 PMCR- 2025/08/02 CRDT- 2025/08/02 23:24 PHST- 2024/09/05 00:00 [received] PHST- 2025/06/27 00:00 [accepted] PHST- 2025/08/03 03:47 [medline] PHST- 2025/08/03 03:46 [pubmed] PHST- 2025/08/02 23:24 [entrez] PHST- 2025/08/02 00:00 [pmc-release] AID - 10.1186/s12889-025-23781-2 [pii] AID - 23781 [pii] AID - 10.1186/s12889-025-23781-2 [doi] PST - epublish SO - BMC Public Health. 2025 Aug 2;25(1):2626. doi: 10.1186/s12889-025-23781-2. PMID- 40752470 OWN - NLM STAT- MEDLINE DCOM- 20250831 LR - 20250831 IS - 1873-7358 (Electronic) IS - 1471-0153 (Linking) VI - 58 DP - 2025 Aug TI - Psychometric performance of the Intuitive Eating Scale-2 in females with anorexia nervosa: An examination of factor structure and Item Response Theory. PG - 102018 LID - S1471-0153(25)00083-2 [pii] LID - 10.1016/j.eatbeh.2025.102018 [doi] AB - The Intuitive Eating Scale-2 (IES-2) is widely used to assess intuitive eating (IE) behaviors, attitudes, and beliefs, yet its application in anorexia nervosa (AN) remains unclear. Given the disrupted interoceptive awareness and heightened cognitive control over eating in AN, it is less certain how IE constructs apply during acute stages of this disorder. This study evaluated the factor structure and item-level performance of the IES-2 in a clinical sample of 150 adolescent and adult females diagnosed with AN, upon admission to a residential treatment facility. Confirmatory Factor Analysis supported a first-order factor structure, suggesting that the four subscales should be treated independently rather than combined into a total IE score, contradicting the original scoring approach. Item 12 ("I am able to cope with negative emotions (e.g., anxiety, sadness) without turning to food for comfort") demonstrated poor factor loadings on the Eating for Physical Rather than Emotional Reasons subscale. Item Response Theory further indicated that item 12 had poor discrimination across levels of the latent trait, supporting its removal. These findings indicate that certain subscales, particularly those assessing emotional eating, may not capture relevant eating behaviors in adolescents and adults with AN. We recommend scoring IES-2 subscales separately and reconsidering the inclusion of item 12 to enhance measurement accuracy in AN. Refining the IES-2 for clinical ED populations may improve its utility in tracking recovery and treatment outcomes. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - Knudsen, Francesca M AU - Knudsen FM AD - Utah State University, Department of Psychology, 2810 Old Main Hill, Logan, UT 84322, United States of America. Electronic address: Francesca.knudsen@usu.edu. FAU - Woolley, Mercedes G AU - Woolley MG AD - Utah State University, Department of Psychology, 2810 Old Main Hill, Logan, UT 84322, United States of America. FAU - Bradshaw, Spencer D AU - Bradshaw SD AD - Utah State University, Department of Psychology, 2810 Old Main Hill, Logan, UT 84322, United States of America. FAU - Lensegrav-Benson, Tera AU - Lensegrav-Benson T AD - Avalon Hills Eating Disorder Specialists, 175 E 100 N, Logan, UT 84321, United States of America; Mindful Path Psychological Services, United States of America. FAU - Quakenbush, Benita AU - Quakenbush B AD - Avalon Hills Eating Disorder Specialists, 175 E 100 N, Logan, UT 84321, United States of America. FAU - Twohig, Michael P AU - Twohig MP AD - Utah State University, Department of Psychology, 2810 Old Main Hill, Logan, UT 84322, United States of America. LA - eng PT - Journal Article DEP - 20250728 PL - United States TA - Eat Behav JT - Eating behaviors JID - 101090048 SB - IM MH - Humans MH - Female MH - *Anorexia Nervosa/psychology/diagnosis MH - Psychometrics MH - Adolescent MH - Adult MH - Factor Analysis, Statistical MH - Young Adult MH - *Feeding Behavior/psychology MH - *Intuition MH - Emotions OTO - NOTNLM OT - Anorexia nervosa OT - Eating disorders OT - Factor structure OT - Intuitive eating OT - Item Response Theory OT - Psychometric validation COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/08/03 03:46 MHDA- 2025/09/01 00:44 CRDT- 2025/08/02 18:34 PHST- 2025/04/02 00:00 [received] PHST- 2025/07/20 00:00 [revised] PHST- 2025/07/23 00:00 [accepted] PHST- 2025/09/01 00:44 [medline] PHST- 2025/08/03 03:46 [pubmed] PHST- 2025/08/02 18:34 [entrez] AID - S1471-0153(25)00083-2 [pii] AID - 10.1016/j.eatbeh.2025.102018 [doi] PST - ppublish SO - Eat Behav. 2025 Aug;58:102018. doi: 10.1016/j.eatbeh.2025.102018. Epub 2025 Jul 28. PMID- 40752192 OWN - NLM STAT- MEDLINE DCOM- 20251105 LR - 20251107 IS - 1094-6950 (Print) IS - 1094-6950 (Linking) VI - 28 IP - 4 DP - 2025 Oct-Dec TI - Relationships between physical activity and bone mineral content and lean mass in Mexican adolescents. PG - 101619 LID - S1094-6950(25)00058-7 [pii] LID - 10.1016/j.jocd.2025.101619 [doi] AB - INTRODUCTION/BACKGROUND: The acquisition and maintenance of bone and lean mass health are significantly influenced by the mechanical environment of the skeleton, with physical activity emerging as an important factor. Our hypothesis proposes that high-impact physical activity improves bone mineral content and lean mass relationship in healthy adolescents depending on gender, pubertal maturity and skeletal location. METHODOLOGY: We assessed the relation between bone mineral content, and lean mass in whole-body and limbs and leisure-time physical activity in Mexican children and adolescents. We conducted an analysis using data from the "Reference values of body composition in Mexican children and adolescents' study", which is a population-based, cross-sectional study. Using standardized protocols, Lunar iDXA instrumentation was used to measure whole-body bone mineral content and lean mass. Using a validated questionnaire, adapted for the Mexican population, the leisure-time physical activity level and the "inactive" condition were determined. ANOVA test was conducted to evaluate curve fitness and produce best-fit equations. Additionally, we used ANCOVA test to evaluate the differences between slopes and intercepts of the curves. RESULTS: All relationships between bone mineral content and lean mass across various regions were highly significant for all Tanner stages (P < 0.001), irrespective of the type of physical activity. Examining all regions (whole-body bone mineral content vs. whole-body lean mass and lower limbs bone mineral content and lean mass, and upper limbs bone mineral content and lean mass) intercepts were significantly higher in Tanner stage 3-5 compared to Tanner stage 1-2 for both genders (P < 0.001). CONCLUSION: These results underscore the nuanced impact of leisure-time physical activity and Tanner stage on the observed relationships, suggesting potential benefits of engaging in specific physical activities during adolescence for bone health during the later stages of puberty. CI - Copyright (c) 2025 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved. FAU - Denova-Gutierrez, Edgar AU - Denova-Gutierrez E AD - Direccion de Nutricion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico. Electronic address: edgar.denova@insp.mx. FAU - Lopez-Gonzalez, Desiree AU - Lopez-Gonzalez D AD - Unidad de Investigacion en Epidemiologia Clinica, Hospital Infantil de Mexico "Federico Gomez", Ciudad de Mexico, Mexico. FAU - Clark, Patricia AU - Clark P AD - Unidad de Investigacion en Epidemiologia Clinica, Hospital Infantil de Mexico "Federico Gomez", Ciudad de Mexico, Mexico. Electronic address: clark@unam.mx. FAU - Munoz-Aguirre, Paloma AU - Munoz-Aguirre P AD - CONAHCYT - Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Cuernavaca, Mexico. FAU - Capozza, Ricardo Francisco AU - Capozza RF AD - Centro de Estudios de Metabolismo Fosfocalcico, Universidad Nacional de Rosario, Rosario, Argentina. FAU - Ferretti, Jose Luis AU - Ferretti JL AD - Centro de Estudios de Metabolismo Fosfocalcico, Universidad Nacional de Rosario, Rosario, Argentina. FAU - Cointry, Gustavo Roberto AU - Cointry GR AD - Centro de Estudios de Metabolismo Fosfocalcico, Universidad Nacional de Rosario, Rosario, Argentina. LA - eng PT - Journal Article DEP - 20250716 PL - United States TA - J Clin Densitom JT - Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry JID - 9808212 SB - IM MH - Humans MH - Adolescent MH - *Bone Density/physiology MH - Mexico MH - Male MH - Female MH - Cross-Sectional Studies MH - *Body Composition MH - Child MH - Absorptiometry, Photon MH - *Exercise/physiology MH - *Motor Activity/physiology MH - Puberty/physiology OTO - NOTNLM OT - Bone mineral content OT - Children OT - Lean mass OT - Leisure-time physical activity OT - Tanner stage COIS- Declaration of competing interest All authors declare no conflict of interest. EDAT- 2025/08/03 03:46 MHDA- 2025/11/06 00:27 CRDT- 2025/08/02 18:08 PHST- 2024/06/05 00:00 [received] PHST- 2025/06/10 00:00 [revised] PHST- 2025/07/14 00:00 [accepted] PHST- 2025/11/06 00:27 [medline] PHST- 2025/08/03 03:46 [pubmed] PHST- 2025/08/02 18:08 [entrez] AID - S1094-6950(25)00058-7 [pii] AID - 10.1016/j.jocd.2025.101619 [doi] PST - ppublish SO - J Clin Densitom. 2025 Oct-Dec;28(4):101619. doi: 10.1016/j.jocd.2025.101619. Epub 2025 Jul 16. PMID- 40751737 OWN - NLM STAT- MEDLINE DCOM- 20250802 LR - 20261010 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 184 IP - 8 DP - 2025 Aug 2 TI - Markers of body fat, the mediating role of alanine aminotransferase, and their association with the risk of metabolic dysfunction-associated steatotic liver disease. PG - 524 LID - 10.1007/s00431-025-06332-0 [doi] AB - Metabolic dysfunction-associated steatotic liver disease (MASLD) in children with obesity correlates with metabolic dysfunction, yet interactions between anthropometrics, liver enzymes, and risk of MASLD remain unclear. This study included 219 children with obesity (79 with MASLD, 140 without MASLD). Demographic, anthropometric, body composition, and biochemical parameters were analyzed. Multivariable logistic regression, stratified analysis, machine learning (Random Forest, LASSO regression), mediation models, and a nomogram were applied. The results showed that children with MASLD demonstrated elevated adiposity markers (weight, 59.8 vs. 45.5 kg; body mass index [BMI], 28.03 vs. 24.56 kg/m(2); waist circumference [WC], 82.64 vs. 69.30 cm; waist-to-height ratio [WHtR], 0.54 vs. 0.49), body composition (body fat mass [BFM], 26.06 vs. 18.13 kg; visceral fat area [VFA], 123.89 vs. 85.06 cm(2)), and liver enzymes (alanine aminotransferase [ALT], 40.00 vs. 19.00 U/L; aspartate aminotransferase [AST], 32.00 vs. 26.00 U/L). Multivariable models and machine learning identified weight, WC, BFM, and ALT as top features (AUC = 0.861). ALT mediated 32.9-38.3% of adiposity-MASLD associations, with persistent direct effects. Adiposity-MASLD links were stronger in males and children with obesity duration > 3 years. Conclusion: Weight, WC, BFM, and ALT synergistically drive MASLD risk (AUC = 0.861), with ALT mediating 32.9-38.3% of adiposity-MASLD associations while direct effects persist. The validated nomogram enables personalized risk stratification, supporting early ALT monitoring and adiposity control in high-risk children with obesity duration > 3 years. CI - (c) 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Li, Yuanyuan AU - Li Y AD - Department of Clinical Nutrition, Xi'an Children's Hospital, NO.69, Xijuyuan Lane, Lianhu District, Xi'an, 710003, Shaanxi, China. FAU - Liu, Ruiping AU - Liu R AD - Department of Clinical Nutrition, Xi'an Children's Hospital, NO.69, Xijuyuan Lane, Lianhu District, Xi'an, 710003, Shaanxi, China. FAU - An, Yao AU - An Y AD - Department of Clinical Nutrition, Xi'an Children's Hospital, NO.69, Xijuyuan Lane, Lianhu District, Xi'an, 710003, Shaanxi, China. FAU - He, Fangyuan AU - He F AD - Department of Clinical Nutrition, Xi'an Children's Hospital, NO.69, Xijuyuan Lane, Lianhu District, Xi'an, 710003, Shaanxi, China. fyandhfy@126.com. LA - eng PT - Journal Article DEP - 20250802 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - EC 2.6.1.2 (Alanine Transaminase) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Male MH - Female MH - *Alanine Transaminase/blood MH - Child MH - *Pediatric Obesity/complications MH - Biomarkers/blood MH - *Fatty Liver/etiology MH - *Adiposity MH - Risk Factors MH - Adolescent MH - Body Mass Index MH - Cross-Sectional Studies MH - Body Composition OTO - NOTNLM OT - ALT OT - Adiposity OT - Children with obesity OT - MASLD OT - Machine learning OT - Mediation analysis COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Xi'an Children's Hospital. Informed consents were provided by every patient in accordance with the Declaration of Helsinki. Consent for publication: The authors participated in this study were all consented for the publication. Competing interests: The authors declare no competing interests. EDAT- 2025/08/03 03:44 MHDA- 2025/08/03 03:45 CRDT- 2025/08/02 11:12 PHST- 2025/04/30 00:00 [received] PHST- 2025/07/08 00:00 [accepted] PHST- 2025/06/25 00:00 [revised] PHST- 2025/08/03 03:45 [medline] PHST- 2025/08/03 03:44 [pubmed] PHST- 2025/08/02 11:12 [entrez] AID - 10.1007/s00431-025-06332-0 [pii] AID - 10.1007/s00431-025-06332-0 [doi] PST - epublish SO - Eur J Pediatr. 2025 Aug 2;184(8):524. doi: 10.1007/s00431-025-06332-0. PMID- 40751267 OWN - NLM STAT- MEDLINE DCOM- 20250802 LR - 20250806 IS - 1746-160X (Electronic) IS - 1746-160X (Linking) VI - 21 IP - 1 DP - 2025 Aug 1 TI - Assessment of symmetry and parental satisfaction after use of customized nasal conformers in unilateral cleft lip repair: a randomized controlled clinical trial. PG - 55 LID - 10.1186/s13005-025-00533-6 [doi] LID - 55 AB - OBJECTIVES: To evaluate the effectiveness of customized nasal conformers used after unilateral cleft lip repair on nasal symmetry and parental satisfaction. MATERIALS AND METHODS: Fourteen medically free, non-syndromic children aged 10-24 weeks with unilateral cleft lip were divided into two groups. All patients underwent primary repair using the Fisher technique. Group I received customized nasal conformers fabricated using digital models, while Group II did not. Anthropometric measurements, including nostril height and width, columella deviation angle, and nasolabial angle were used to assess nasal symmetry between both groups. Parental satisfaction was evaluated using the Cleft Evaluation Profile (CEP). RESULTS: At six months postoperatively, Group I showed no significant difference between cleft and non-cleft sides across all parameters. In contrast, Group II exhibited significant asymmetry in nostril height and width, although no significant difference was observed in the nasolabial angle. CEP scores showed significantly higher satisfaction in fathers for lip, nose, and profile, and in mothers for nose and profile. No significant difference was noted in teeth appearance for either parent group. Intra-examiner reliability was reliable across all parameters. CONCLUSIONS: The use of customized postsurgical nasal conformers in unilateral cleft lip repair was associated with improved symmetry between cleft and non-cleft sides and appeared to reduce relapse, which may have contributed to increased parental satisfaction with the treatment. TRIAL REGISTRATION: Was retrospectively registered at Clinicaltrials.gov on 23/10/2024 (NCT06637488). CI - (c) 2025. The Author(s). FAU - Khodir, Mahmoud Akram AU - Khodir MA AUID- ORCID: 0000-0001-7195-9751 AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Alexandria University, Champlion Street, El-Azarita, Alexandria, Egypt. mahmoud.ragy@alexu.edu.eg. FAU - Osman, Saeeda Mahmoud AU - Osman SM AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Alexandria University, Champlion Street, El-Azarita, Alexandria, Egypt. FAU - Ragab, Hala Ragaa AU - Ragab HR AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Alexandria University, Champlion Street, El-Azarita, Alexandria, Egypt. FAU - AboulHassan, Mamdouh Ahmed AU - AboulHassan MA AD - Department of General Surgery, Plastic Section, Faculty of Medicine, Cairo University, Al-Saray Street, Al-Manial, Cairo, Egypt. FAU - Oraby, Mona Samy AU - Oraby MS AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Alexandria University, Champlion Street, El-Azarita, Alexandria, Egypt. LA - eng SI - ClinicalTrials.gov/NCT06637488 PT - Journal Article PT - Randomized Controlled Trial DEP - 20250801 PL - England TA - Head Face Med JT - Head & face medicine JID - 101245792 SB - IM MH - Humans MH - *Cleft Lip/surgery MH - Female MH - Male MH - *Parents/psychology MH - Infant MH - *Nose/surgery MH - *Patient Satisfaction MH - Treatment Outcome MH - *Plastic Surgery Procedures/methods PMC - PMC12315412 OTO - NOTNLM OT - Cleft lip repair OT - Fisher OT - Nasal conformer OT - Parental satisfaction COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Research Ethics Committee of Alexandria University Faculty of Dentistry (IRB No.001056 - IORG 0008839). The study protocol followed the Helsinki principles. All children's guardians signed an informed consent after discussing all processes and potential risks and complications. Consent for publication: Informed consent for publication was obtained from all children's guardians. Competing interests: The authors declare no competing interests. EDAT- 2025/08/02 10:42 MHDA- 2025/08/02 10:43 PMCR- 2025/08/01 CRDT- 2025/08/02 00:43 PHST- 2025/05/30 00:00 [received] PHST- 2025/07/14 00:00 [accepted] PHST- 2025/08/02 10:43 [medline] PHST- 2025/08/02 10:42 [pubmed] PHST- 2025/08/02 00:43 [entrez] PHST- 2025/08/01 00:00 [pmc-release] AID - 10.1186/s13005-025-00533-6 [pii] AID - 533 [pii] AID - 10.1186/s13005-025-00533-6 [doi] PST - epublish SO - Head Face Med. 2025 Aug 1;21(1):55. doi: 10.1186/s13005-025-00533-6. PMID- 40751144 OWN - NLM STAT- MEDLINE DCOM- 20250802 LR - 20260617 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 25 IP - 1 DP - 2025 Aug 1 TI - Associations of physical activity intensity and specific sedentary behaviors during after-school and weekend with overweight and obesity among preschool children. PG - 586 LID - 10.1186/s12887-025-05918-9 [doi] LID - 586 AB - BACKGROUND: This cross-sectional study examined the association between physical activity (PA) intensity and specific sedentary behaviors (SB) among preschool children with overweight or obesity. METHODS: A sample of 1,115 preschoolers aged 3-6 years in Taipei City was recruited from March to April 2022. Parents completed a validated, self-administered survey assessing the child's PA intensity (light [LPA], moderate-to-vigorous [MVPA]) and specific SB (total sedentary time [ST], screen-based sedentary time [SST], non-screen sedentary time [NSST], electronic game screen time [EST]). Child's height and weight were measured, and age- and sex-specific body mass index z-scores were calculated. Logistic regression was used in this study. RESULTS: Overall, 23% of the preschool children (age: 4.85 +/- 0.91y; 49.9% female) were identified as having overweight or obesity. After adjusting for confounding factors, the highest quartile of total PA, LPA, and MVPA during the weekend was significantly associated with a lower risk of being overweight or having obesity compared with the lowest quartile. Furthermore, the highest quartile of ST and EST after school were associated with a higher risk of being overweight or having obesity compared with the lowest quartile. CONCLUSIONS: The strategies to prevent overweight and obesity among preschool children should consider cumulative PA of any intensity during the weekend, even light PA. Moreover, decreasing screen time and playing video games after school might help prevent overweight/obesity. CI - (c) 2025. The Author(s). FAU - Hsueh, Ming-Chun AU - Hsueh MC AD - Graduate Institute of Sport Pedagogy, University of Taipei, No. 101, Sec. 2, Jhongcheng Rd., Shilin Dist, Taipei, 11153, Taiwan, Republic of China. boxeo@utaipei.edu.tw. FAU - Chen, Yu-Hsuan AU - Chen YH AD - Graduate Institute of Sport Pedagogy, University of Taipei, No. 101, Sec. 2, Jhongcheng Rd., Shilin Dist, Taipei, 11153, Taiwan, Republic of China. LA - eng GR - NSTC 113-2410-H-845-041/National Science and Technology Council/ PT - Journal Article DEP - 20250801 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Sedentary Behavior MH - Child, Preschool MH - Male MH - Female MH - Cross-Sectional Studies MH - *Exercise MH - *Pediatric Obesity/epidemiology MH - Child MH - *Overweight/epidemiology MH - Taiwan/epidemiology MH - Body Mass Index MH - Screen Time PMC - PMC12315338 OTO - NOTNLM OT - Body composition OT - Childcare OT - Early childhood OT - Health behaviors OT - Light physical activity OT - Sedentary behavior COIS- Declarations. Ethics approval and consent to participate: The study protocol was approved by the Ethics Committee of the University of Taipei (approval number: IRB-2022-006). Informed consent was obtained from the parents or legal guardians of all participants, who read the study's purpose statement and provided the completed questionnaire to us. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/08/02 10:43 MHDA- 2025/08/02 10:44 PMCR- 2025/08/01 CRDT- 2025/08/02 00:20 PHST- 2025/02/14 00:00 [received] PHST- 2025/06/30 00:00 [accepted] PHST- 2025/08/02 10:44 [medline] PHST- 2025/08/02 10:43 [pubmed] PHST- 2025/08/02 00:20 [entrez] PHST- 2025/08/01 00:00 [pmc-release] AID - 10.1186/s12887-025-05918-9 [pii] AID - 5918 [pii] AID - 10.1186/s12887-025-05918-9 [doi] PST - epublish SO - BMC Pediatr. 2025 Aug 1;25(1):586. doi: 10.1186/s12887-025-05918-9. PMID- 40748388 OWN - NLM STAT- MEDLINE DCOM- 20251112 LR - 20261010 IS - 1432-1998 (Electronic) IS - 0301-0449 (Linking) VI - 55 IP - 12 DP - 2025 Nov TI - Quantitative ultrasound-derived fat fraction for identifying pediatric patients with metabolic dysfunction-associated steatotic liver disease: a prospective study. PG - 2590-2600 LID - 10.1007/s00247-025-06349-5 [doi] AB - BACKGROUND: Metabolic dysfunction-associated steatotic liver disease is increasingly affecting younger populations. Ultrasound-derived fat fraction is a technique used in ultrasound to quantify liver fat content. The diagnostic performance of ultrasound-derived fat fraction in pediatric patients with metabolic dysfunction-associated steatotic liver disease is yet to be evaluated. OBJECTIVE: To evaluate the diagnostic performance of ultrasound-derived fat fraction measurement in detecting and grading hepatic steatosis in pediatric patients with metabolic dysfunction-associated steatotic liver disease. MATERIALS AND METHODS: In this prospective study, pediatric patients diagnosed with metabolic dysfunction-associated steatotic liver disease were enrolled. Six acquisitions of ultrasound-derived fat fraction were obtained. Taking magnetic resonance imaging (MRI)-proton density fat fraction as a reference standard, the area under the receiver operating characteristic curve (AUC) was performed to evaluate the diagnostic performance of ultrasound-derived fat fraction. Youden index was used to determine the cutoff value of ultrasound-derived fat fraction. Correlation coefficient and Bland-Altman plot were performed. RESULTS: From April 2024 to March 2025, 32 patients (median age, 12 years; median body mass index, 29.7 kg/m(2)) were included. The ultrasound-derived fat fraction values showed a positive correlation with MRI-proton density fat fraction (r = 0.72). The ultrasound-derived fat fraction values and MRI-proton density fat fraction had a mean bias of 3.3% (95% limits of agreement: -16.4, 23.1). Using MRI-proton density fat fractions >/= 5%, >/= 15%, and >/= 25% as the reference standard for diagnosing hepatic steatosis grade >/= S1, >/= S2, and S3, the AUCs of ultrasound-derived fat fraction were 0.84, 0.88, and 0.88, with the cutoff values of 9.5%, 10.5%, and 12.8%, respectively. CONCLUSION: Ultrasound-derived fat fraction demonstrates promising diagnostic performance for detecting and grading hepatic steatosis in pediatric patients with metabolic dysfunction-associated steatotic liver disease within this cohort. CI - (c) 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Huang, Yunlin AU - Huang Y AD - Department of Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China. FAU - Sun, Chao AU - Sun C AD - Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Lab of Pediatric Gastroenterology and Nutrition, 1665 Kong Jiang Road, Shanghai, 200092, China. FAU - Cheng, Juan AU - Cheng J AD - Department of Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China. FAU - Wang, Ying AU - Wang Y AD - Department of Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China. FAU - Qiu, Yijie AU - Qiu Y AD - Department of Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China. FAU - Wang, Shiwen AU - Wang S AD - Department of Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China. FAU - Wang, Ming AU - Wang M AD - Department of Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China. FAU - Wei, Li AU - Wei L AD - Department of Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China. FAU - Cheng, Rui AU - Cheng R AD - Department of Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China. FAU - Fan, Jian-Gao AU - Fan JG AD - Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Lab of Pediatric Gastroenterology and Nutrition, 1665 Kong Jiang Road, Shanghai, 200092, China. fanjiangao@xinhuamed.com.cn. FAU - Dong, Yi AU - Dong Y AD - Department of Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China. drdaisydong@hotmail.com. LA - eng GR - 2023ZD0508700/Noncommunicable Chronic Diseases-National Science and Technology Major Project of China/ GR - M-0504/Sino-German Mobility Program of NSFC and DFG/ GR - 82071942/National Natural Science Foundation of China/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250801 PL - Germany TA - Pediatr Radiol JT - Pediatric radiology JID - 0365332 SB - IM MH - Humans MH - Prospective Studies MH - Child MH - Male MH - Female MH - Ultrasonography/methods MH - *Fatty Liver/diagnostic imaging MH - Adolescent MH - Child, Preschool MH - Liver/diagnostic imaging OTO - NOTNLM OT - Child OT - Fatty liver OT - Magnetic resonance imaging OT - Prospective study COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/08/01 12:33 MHDA- 2025/11/13 00:29 CRDT- 2025/08/01 11:15 PHST- 2025/04/14 00:00 [received] PHST- 2025/07/11 00:00 [accepted] PHST- 2025/07/10 00:00 [revised] PHST- 2025/11/13 00:29 [medline] PHST- 2025/08/01 12:33 [pubmed] PHST- 2025/08/01 11:15 [entrez] AID - 10.1007/s00247-025-06349-5 [pii] AID - 10.1007/s00247-025-06349-5 [doi] PST - ppublish SO - Pediatr Radiol. 2025 Nov;55(12):2590-2600. doi: 10.1007/s00247-025-06349-5. Epub 2025 Aug 1. PMID- 40747221 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250803 IS - 1948-5182 (Print) IS - 1948-5182 (Electronic) VI - 17 IP - 7 DP - 2025 Jul 27 TI - Three-year outcomes of tumor necrosis factor alpha inhibitor therapy in rheumatoid arthritis patients with elevated liver enzymes. PG - 108051 LID - 10.4254/wjh.v17.i7.108051 [doi] LID - 108051 AB - BACKGROUND: Elevated liver enzymes in rheumatoid arthritis (RA) are often attributed to multiple factors including disease activity and treatment-related adverse effects. Tumor necrosis factor inhibitors (TNFi) have shown mixed effects on liver function, with varying safety profiles among agents. AIM: To evaluate the hepatic safety of TNFi therapy-etanercept and adalimumab-in RA patients with elevated liver enzymes. METHODS: A retrospective chart review was conducted for RA patients with elevated liver enzymes receiving TNFi at a single center between January 1, 2019, and September 30, 2024. Out of the patients screened, 9 met the inclusion criteria. Trends in liver enzymes, fibrosis-4 (FIB-4) score, and changes in the Child-Pugh class were analyzed at 1-year and 3-year follow-up periods. RESULTS: Among 9 patients (4 on adalimumab, 5 on etanercept), the median age was 56 years [interquartile range (IQR): 49.5-64.5 years], 77.8% were female, and the median body mass index was 36.99 kg/m(2) (IQR: 30.95-43.43 kg/m(2)). Median baseline FIB-4 was 1.25 (IQR: 1.02-1.65), with no cirrhosis observed at baseline. Aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase levels declined consistently, with significant reductions from baseline to 3 years (P = 0.003). FIB-4 scores also significantly decreased (P = 0.003), while albumin, bilirubin, and Child-Pugh class remained stable at the 3-year follow-up. At 3 years, 66.7% achieved RA remission (P = 0.03). CONCLUSION: TNFi therapy (adalimumab or etanercept) was associated with significant improvement in liver enzymes and FIB-4 without hepatic decompensation, supporting its safety in our cohort of RA patients with liver involvement. Larger prospective studies are warranted to further validate these findings. CI - (c)The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. FAU - Duggal, Shivangini AU - Duggal S AD - Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, United States. sduggal@ttuhsc.edu. FAU - Kattamuri, Lakshmi AU - Kattamuri L AD - Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, United States. FAU - Sairam, Shrilekha AU - Sairam S AD - Division of Rheumatology, Department of Internal Medicine, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, United States. LA - eng PT - Journal Article PL - United States TA - World J Hepatol JT - World journal of hepatology JID - 101532469 PMC - PMC12308560 OTO - NOTNLM OT - Adalimumab OT - Elevated liver enzymes OT - Etanercept OT - Fibrosis-4 scores OT - Rheumatoid arthritis COIS- Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript. EDAT- 2025/08/01 11:33 MHDA- 2025/08/01 11:34 PMCR- 2025/07/27 CRDT- 2025/08/01 05:11 PHST- 2025/04/08 00:00 [received] PHST- 2025/04/29 00:00 [revised] PHST- 2025/06/13 00:00 [accepted] PHST- 2025/08/01 11:34 [medline] PHST- 2025/08/01 11:33 [pubmed] PHST- 2025/08/01 05:11 [entrez] PHST- 2025/07/27 00:00 [pmc-release] AID - 10.4254/wjh.v17.i7.108051 [doi] PST - ppublish SO - World J Hepatol. 2025 Jul 27;17(7):108051. doi: 10.4254/wjh.v17.i7.108051. PMID- 40745624 OWN - NLM STAT- MEDLINE DCOM- 20260105 LR - 20260714 IS - 1469-8749 (Electronic) IS - 0012-1622 (Print) IS - 0012-1622 (Linking) VI - 68 IP - 2 DP - 2026 Feb TI - Brain lesion extent, growth, and body composition in children with cerebral palsy. PG - 199-210 LID - 10.1111/dmcn.16427 [doi] AB - AIM: To investigate the relationship between growth, body composition, and the extent of brain lesion measured using structural magnetic resonance imaging (MRI) in children with cerebral palsy (CP). METHOD: This prospective population-based cohort study recorded 359 assessments from 124 children with CP aged 18 months to 13 years (38% female, Gross Motor Function Classification System [GMFCS] levels I = 50, II = 24, III = 17, IV = 12, and V = 21). A neurologist assessed the extent of the brain lesion using a validated semi-quantitative scale (global, basal ganglia/brainstem, hemispheric and corpus callosum scores). Height (HTZ), weight (WTZ), and head circumference (HDZ) z-scores were calculated. The Fat Mass Index (FMI) and Fat-Free Mass Index (FFMI) were determined using a deuterium dilution technique, bioelectrical impedance or dual-energy X-ray absorptiometry, and height. Data were analysed using mixed-effects linear regression. RESULTS: Greater global (beta = -0.04, 95% confidence interval [CI] = -0.07 to -0.02), basal ganglia/brainstem (beta = -0.06, 95% CI = -0.11 to -0.02), corpus callosum (beta = -0.27, 95% CI = -0.27 to -0.12), and hemispheric (beta = -0.08, 95% CI = -0.12 to -0.04) scores were associated with lower HTZ. Greater global (beta = -0.03,95% CI = -0.06 to -0.01) and corpus callosum (beta = -0.23, 95% CI = -0.40 to -0.06) scores were associated with lower WTZ. A greater hemispheric score (beta = -0.06, 95% CI = -0.119 to -0.001) was associated with lower HDZ. Semi-quantitative MRI scores were not associated with FMI or FFMI. INTERPRETATION: Greater extent of the brain lesion was significantly associated with lower HDZ, HTZ, and WTZ but not body composition in children with CP aged 18 months to 13 years. CI - (c) 2025 The Author(s). Developmental Medicine & Child Neurology published by John Wiley & Sons Ltd on behalf of Mac Keith Press. FAU - Oftedal, Stina AU - Oftedal S AUID- ORCID: 0000-0002-6769-1454 AD - Queensland Cerebral Palsy and Rehabilitation Research Centre, Faculty of Health, Medicine and Behavioral Science, The University of Queensland, Brisbane, Queensland, Australia. FAU - Fiori, Simona AU - Fiori S AD - Neuroscience and Medical Genetics Department, Meyer Children's Hospital IRCCS, University of Florence, Florence, Italy. FAU - Bell, Kristie L AU - Bell KL AUID- ORCID: 0000-0002-4795-1079 AD - Children's Health Queensland Hospital and Health Service, South Brisbane, Queensland, Australia. FAU - Benfer, Katherine A AU - Benfer KA AUID- ORCID: 0000-0002-7252-5063 AD - Queensland Cerebral Palsy and Rehabilitation Research Centre, Faculty of Health, Medicine and Behavioral Science, The University of Queensland, Brisbane, Queensland, Australia. FAU - Sakzewski, Leanne AU - Sakzewski L AUID- ORCID: 0000-0001-5395-544X AD - Queensland Cerebral Palsy and Rehabilitation Research Centre, Faculty of Health, Medicine and Behavioral Science, The University of Queensland, Brisbane, Queensland, Australia. FAU - Ware, Robert S AU - Ware RS AD - Griffith Biostatistics Unit, Griffith University, Brisbane, Queensland, Australia. FAU - Davies, Peter S W AU - Davies PSW AD - Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia. FAU - Boyd, Roslyn N AU - Boyd RN AUID- ORCID: 0000-0002-4919-5975 AD - Queensland Cerebral Palsy and Rehabilitation Research Centre, Faculty of Health, Medicine and Behavioral Science, The University of Queensland, Brisbane, Queensland, Australia. LA - eng GR - 1037220/National Health and Medical Research Council/ GR - 1077257/National Health and Medical Research Council/ GR - 465128/National Health and Medical Research Council/ GR - 569605/National Health and Medical Research Council/ PT - Journal Article DEP - 20250731 PL - England TA - Dev Med Child Neurol JT - Developmental medicine and child neurology JID - 0006761 SB - IM MH - Humans MH - *Cerebral Palsy/pathology/physiopathology/diagnostic imaging MH - Female MH - Child MH - *Body Composition/physiology MH - Child, Preschool MH - Male MH - Adolescent MH - Infant MH - Magnetic Resonance Imaging MH - *Brain/pathology/diagnostic imaging MH - Prospective Studies MH - Cohort Studies PMC - PMC12766548 EDAT- 2025/08/01 06:28 MHDA- 2026/01/05 06:47 PMCR- 2026/01/05 CRDT- 2025/08/01 00:37 PHST- 2025/06/20 00:00 [revised] PHST- 2024/12/16 00:00 [received] PHST- 2025/06/24 00:00 [accepted] PHST- 2026/01/05 06:47 [medline] PHST- 2025/08/01 06:28 [pubmed] PHST- 2025/08/01 00:37 [entrez] PHST- 2026/01/05 00:00 [pmc-release] AID - DMCN16427 [pii] AID - 10.1111/dmcn.16427 [doi] PST - ppublish SO - Dev Med Child Neurol. 2026 Feb;68(2):199-210. doi: 10.1111/dmcn.16427. Epub 2025 Jul 31. PMID- 40745351 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260307 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 13 IP - 1 DP - 2025 Jul 31 TI - Preliminary validation of developmental weight suppression in youth with transdiagnostic eating disorders. PG - 163 LID - 10.1186/s40337-025-01349-0 [doi] LID - 163 AB - BACKGROUND: Weight suppression (WS), traditionally defined as the difference between highest past and current weights at adult height, is a correlate and predictor of eating disorder (ED) psychopathology. However, for growing adolescents, it may be more appropriate to use a developmentally-adjusted calculation of WS. This study compared how developmental WS, calculated using zBMIs, compared with traditional WS, calculated using weights, as correlate of ED psychopathology in treatment-seeking adolescents with transdiagnostic EDs. METHODS: Adolescents with EDs (N = 93) completed the Eating Disorder Examination Questionnaire (EDE-Q) at presentation to outpatient care. Weight histories were extracted from medical records. Regressions examined the association between each measure of WS and EDE-Q scores, adjusting for ED diagnosis. Dominance analyses with bootstrapping assessed whether developmental WS outperformed traditional WS. RESULTS: Developmental WS negatively associated with EDE-Q Shape (sr(2) = 0.05, p =.020) and Weight Concern (sr(2) = 0.05, p =.021). In contrast, traditional WS did not associate with any EDE-Q scores. Although dominance weights were larger for developmental WS compared to traditional WS, bootstrap sampling revealed no significant differences in magnitudes. CONCLUSIONS: Results preliminarily support developmental WS as a correlate of body image concerns in youth with EDs, though replication is needed. CI - (c) 2025. The Author(s). FAU - Singh, Simar AU - Singh S AD - Department of Psychiatry and Behavioral Sciences, Univeristy of California San Francisco, San Francisco, CA, USA. simar.singh2@ucsf.edu. FAU - Reilly, Erin E AU - Reilly EE AD - Department of Psychiatry and Behavioral Sciences, Univeristy of California San Francisco, San Francisco, CA, USA. FAU - Drury, Catherine R AU - Drury CR AD - Department of Psychiatry and Behavioral Sciences, Univeristy of California San Francisco, San Francisco, CA, USA. FAU - Duffy, Alan AU - Duffy A AD - Eating Recovery Center and Pathlight Mood & Anxiety Center, Denver, CO, USA. FAU - Mehler, Philip S AU - Mehler PS AD - Eating Recovery Center and Pathlight Mood & Anxiety Center, Denver, CO, USA. AD - Acute Center for Eating Disorders at Denver Health, Denver, CO, USA. AD - University of Colorado School of Medicine, Denver, CO, USA. FAU - Accurso, Erin C AU - Accurso EC AD - Department of Psychiatry and Behavioral Sciences, Univeristy of California San Francisco, San Francisco, CA, USA. AD - Philip R. Lee Institute for Health Policy Studies, San Francisco, CA, USA. FAU - Zucker, Kianna AU - Zucker K AD - Department of Psychiatry and Behavioral Sciences, Univeristy of California San Francisco, San Francisco, CA, USA. FAU - Lynch, Naomi AU - Lynch N AD - Department of Psychiatry and Behavioral Sciences, Univeristy of California San Francisco, San Francisco, CA, USA. FAU - Le Grange, Daniel AU - Le Grange D AD - Department of Psychiatry and Behavioral Sciences, Univeristy of California San Francisco, San Francisco, CA, USA. AD - Department of Psychiatry and Behavioral Sciences, The University of Chicago, Chicago, IL, USA. FAU - Rienecke, Renee D AU - Rienecke RD AD - Eating Recovery Center and Pathlight Mood & Anxiety Center, Denver, CO, USA. AD - Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, USA. FAU - Gorrell, Sasha AU - Gorrell S AD - Department of Psychiatry and Behavioral Sciences, Univeristy of California San Francisco, San Francisco, CA, USA. LA - eng GR - K23 MH126201/MH/NIMH NIH HHS/United States GR - T32 MH018261/MH/NIMH NIH HHS/United States GR - T32MH018261/MH/NIMH NIH HHS/United States GR - R25 NS117367/NS/NINDS NIH HHS/United States GR - K23 MH131871/MH/NIMH NIH HHS/United States GR - John E. Cox Fund/University of California, San Francisco/ GR - K23 MH120347/MH/NIMH NIH HHS/United States GR - K23MH131871/MH/NIMH NIH HHS/United States GR - K23MH126201/MH/NIMH NIH HHS/United States GR - Young Investigator Award/Brain and Behavior Research Foundation/ GR - K23MH120347/MH/NIMH NIH HHS/United States PT - Journal Article DEP - 20250731 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC12315326 OAB - Weight suppression (WS), traditionally calculated as the difference between highest past and current weights, predicts transdiagnostic eating disorder (ED) onset and positively correlates with ED symptoms. However, a simple subtraction of weights does not capture differences with respect to height, age, and sex that may impact WS's associations with ED pathology. This is a particular concern for youth, who are growing in age and height. For instance, 8 kg of WS may have a different impact on a 10-year-old who is 142 cm versus an 18-year-old who is 172 cm. To address this shortcoming, a "developmentally-adjusted" calculation of WS that quantifies the difference between highest premorbid and current BMI z-scores was recently published. The present study is the first to quantitatively compare how traditional versus developmentally-adjusted calculations of WS differentially associate with baseline ED pathology in treatment-seeking youth with transdiagnostic EDs. In contrast to the traditional calculation of WS, which did not associate with any ED symptoms, we found that the developmentally-adjusted calculation negatively associated with global eating pathology and body image concerns. Our findings provide quantitative evidence that a z-BMI-based calculation of WS, as opposed to a weight-based calculation, may be a better correlate of ED symptomatology in youth. OABL- eng OTO - NOTNLM OT - Adolescence OT - Eating disorders OT - Weight suppression COIS- Declarations. Ethics approval and consent to participate: Parents or legal guardians provided informed consent for participation and adolescents provided assent. The study was approved by the University's Institutional Review Board (IRB #15-16093). All procedures were conducted in accordance with the Declaration of Helsinki. Parents or legal guardians provided informed consent for participation, and patients provided assent (or consent if >/= 18 years). Consent for publication: N/A. Competing interests: Dr. Le Grange receives royalties from Guilford Press and Routledge and is co-director of the Training Institute for Child and Adolescent Eating Disorders, LLC. Dr. Rienecke receives consulting fees from the Training Institute for Child and Adolescent Eating Disorders, LLC, and royalties from Routledge and Hachette Book Group, Inc. EDAT- 2025/08/01 00:29 MHDA- 2025/08/01 00:30 PMCR- 2025/07/31 CRDT- 2025/07/31 23:47 PHST- 2025/03/20 00:00 [received] PHST- 2025/07/20 00:00 [accepted] PHST- 2025/08/01 00:30 [medline] PHST- 2025/08/01 00:29 [pubmed] PHST- 2025/07/31 23:47 [entrez] PHST- 2025/07/31 00:00 [pmc-release] AID - 10.1186/s40337-025-01349-0 [pii] AID - 1349 [pii] AID - 10.1186/s40337-025-01349-0 [doi] PST - epublish SO - J Eat Disord. 2025 Jul 31;13(1):163. doi: 10.1186/s40337-025-01349-0. PMID- 40743463 OWN - NLM STAT- MEDLINE DCOM- 20251010 LR - 20251010 IS - 1753-4887 (Electronic) IS - 0029-6643 (Linking) VI - 83 IP - 11 DP - 2025 Nov 1 TI - Validity Evidence of Screening Tools for Pediatric Feeding Disorders: A Systematic Review. PG - 2123-2143 LID - 10.1093/nutrit/nuaf128 [doi] AB - CONTEXT: Pediatric feeding disorders (PFDs) present challenges involving food intake, feeding skills, and psychosocial or clinical dysfunctions affecting children and caregivers. Early identification and accurate evaluation are essential for improving outcomes. Despite the availability of various instruments, evidence for their reliability and validity in clinical practice and research remains limited. OBJECTIVE: The aim for this systematic review was to assess the evidence of the validity of instruments used to evaluate PFDs. DATA SOURCES: Articles were searched across Medline, Embase, APA PsycInfo, Centre for Agricultural Bioscience International, Web of Science, and Cochrane Library databases, and grey literature up to August 2024, including studies without restrictions on date or language. DATA EXTRACTION: Studies on PFD assessment instruments were included. Two independent reviewers assessed eligibility, extracted data (covering study and instrument characteristics, domains, psychometric properties, validation outcomes), and evaluated methodological quality. DATA ANALYSIS: Narrative synthesis was used to describe the psychometric properties of the instruments. The methodological quality of the included studies was evaluated using the COSMIN Risk of Bias checklist. Instrument validity was primarily assessed using minimum adequacy criteria (content, criterion, and construct validity or diagnostic performance) based on previously published cutoff points. COSMIN criteria for good measurement properties were also applied to assess the instruments. A total of 19 instruments for evaluating PFDs were reviewed across 40 studies. Among these, 10 met the minimum adequacy criteria, including 8 for feeding problems and 2 for dysphagia, regardless of their original language or cultural context. CONCLUSION: This review underscores the lack of instruments with adequate psychometric properties to evaluate PFDs. Although some instruments meet minimum adequacy criteria, limitations in validation methods and insufficient robustness highlight the need for further research and standardization to improve their use in clinical and research contexts. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration No. CRD42023411223. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Cardoso, Haissa I AU - Cardoso HI AUID- ORCID: 0009-0008-4094-8329 AD - Postgraduate Program in Epidemiology, Federal University of Rio Grande do Sul, Porto Alegre, RS, 90035-003, Brazil. AD - Postgraduate Program in Food, Nutrition, and Health, Federal University of Rio Grande do Sul, Porto Alegre, RS, 90035-003, Brazil. FAU - de Vargas, Bruna O AU - de Vargas BO AUID- ORCID: 0000-0001-6848-0141 AD - Department of Nutrition, Undergraduate Program in Nutrition, Federal University of Rio Grande do Sul, Porto Alegre, RS, 90610-264, Brazil. FAU - Correa, Rafaela da S AU - Correa RDS AUID- ORCID: 0000-0003-4235-6171 AD - Department of Nutrition, Undergraduate Program in Nutrition, Federal University of Rio Grande do Sul, Porto Alegre, RS, 90610-264, Brazil. FAU - Mattiello, Rita AU - Mattiello R AUID- ORCID: 0000-0002-0548-3342 AD - Postgraduate Program in Epidemiology, Federal University of Rio Grande do Sul, Porto Alegre, RS, 90035-003, Brazil. AD - Department of Social Medicine, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, RS, 90610-264, Brazil. FAU - Bosa, Vera L AU - Bosa VL AUID- ORCID: 0000-0002-6283-9640 AD - Postgraduate Program in Food, Nutrition, and Health, Federal University of Rio Grande do Sul, Porto Alegre, RS, 90035-003, Brazil. AD - Department of Nutrition, Undergraduate Program in Nutrition, Federal University of Rio Grande do Sul, Porto Alegre, RS, 90610-264, Brazil. AD - Nutrition and Dietetics Division, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, 90035-903, Brazil. LA - eng GR - FAPERGS/ GR - Research Support Foundation of the State of Rio Grande do Sul/ GR - Research Incentive Fund/ GR - Coordination for the Improvement of Higher Education Personnel/ GR - National Council for Scientific and Technological Development/ PT - Journal Article PT - Systematic Review PL - United States TA - Nutr Rev JT - Nutrition reviews JID - 0376405 SB - IM MH - Humans MH - Reproducibility of Results MH - Child MH - Psychometrics MH - *Feeding and Eating Disorders of Childhood/diagnosis MH - *Mass Screening/methods MH - *Feeding and Eating Disorders/diagnosis MH - Child, Preschool OTO - NOTNLM OT - feeding and eating disorders of childhood OT - pediatric feeding disorders OT - psychometrics OT - surveys and questionnaires EDAT- 2025/07/31 18:28 MHDA- 2025/10/10 17:32 CRDT- 2025/07/31 15:43 PHST- 2025/10/10 17:32 [medline] PHST- 2025/07/31 18:28 [pubmed] PHST- 2025/07/31 15:43 [entrez] AID - 8220397 [pii] AID - 10.1093/nutrit/nuaf128 [doi] PST - ppublish SO - Nutr Rev. 2025 Nov 1;83(11):2123-2143. doi: 10.1093/nutrit/nuaf128. PMID- 40743120 OWN - NLM STAT- MEDLINE DCOM- 20250731 LR - 20250803 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 7 DP - 2025 TI - Adaptation and validation of the modified weight bias internalization scale (WBIS-M) in Brazilian adults. PG - e0328176 LID - 10.1371/journal.pone.0328176 [doi] LID - e0328176 AB - Internalized weight stigma refers to individuals' self-stigmatization, leading to self-devaluation. This research aimed to conduct an adaptation and validation study of the Modified Weight Bias Internalization Scale (WBIS-M) for Brazil. A sample of 418 adults (253 women; mean age = 30.8 years, SD = 10.4) completed the WBIS-M and measures of anti-fat attitudes, body image, disordered eating, binge eating, and self-esteem. Exploratory factor analyses (EFA) and confirmatory factor analyses (CFA) were conducted to examine the factor structure of the WBIS-M. Measurement invariance across gender was tested with multigroup CFA. Internal consistency was assessed using omega and alpha. Relationships between the WBIS-M scores and external measures were analyzed using Pearson's and Spearman's correlations, t-tests, and Cohen's d for effect size. EFA and CFA showed that the 10-item and 1-factor WBIS-M model fit reasonably well (CFI and TLI >/= .98, SRMR 2 h, as defined by the American Academy of Pediatrics (AAP)] across devices and timeframes at various levels. Smartphones emerged as the dominant medium for adolescents' screen-based entertainment across all timeframes, with 64.6% (on weekdays), 64.8% (on weeknights), and 81.7% (on weekend days) exceeding the 2-h threshold of EMST on these devices. Conversely, television entertainment declined, with 33.1% and 35.7% reporting no entertainment consumption during weekdays and weeknights, respectively. Significant associations were found between EMST and factors such as age, gender, grade level, parental employment, parental education, and family size (p < 0.05). Older adolescents were positively associated with weekday smartphone entertainment (rho = 0.110, p < 0.01), while negatively correlated with television entertainment on weekend days (rho = -0.110, p < 0.01). This study elucidates the complex patterns of adolescents' EMST, highlighting the roles of demographic, familial, and socioeconomic factors. Interventions should promote media literacy by raising awareness of the implications of excessive EMST engagement. CI - Copyright (c) 2025 Sebsbie and Tsegaye. FAU - Sebsbie, Semen AU - Sebsbie S AD - School of Media and Communication, Addis Ababa University, Addis Ababa, Ethiopia. AD - Department of English Language and Literature, Kotebe University of Education, Addis Ababa, Ethiopia. FAU - Tsegaye, Anteneh AU - Tsegaye A AD - School of Media and Communication, Addis Ababa University, Addis Ababa, Ethiopia. LA - eng PT - Journal Article DEP - 20250715 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC12308158 OTO - NOTNLM OT - Uses and Gratifications Theory OT - adolescents OT - entertainment screen time OT - media literacy OT - screen media devices OT - timeframes COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/07/31 12:11 MHDA- 2025/07/31 12:12 PMCR- 2025/07/15 CRDT- 2025/07/31 05:40 PHST- 2025/01/09 00:00 [received] PHST- 2025/06/17 00:00 [accepted] PHST- 2025/07/31 12:12 [medline] PHST- 2025/07/31 12:11 [pubmed] PHST- 2025/07/31 05:40 [entrez] PHST- 2025/07/15 00:00 [pmc-release] AID - 10.3389/fpsyg.2025.1549080 [doi] PST - epublish SO - Front Psychol. 2025 Jul 15;16:1549080. doi: 10.3389/fpsyg.2025.1549080. eCollection 2025. PMID- 40740357 OWN - NLM STAT- MEDLINE DCOM- 20250731 LR - 20250802 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Factors associated with vegetable and fruit intake among adolescents with overweight and obesity in Selangor from 2020 to 2021. PG - 1539506 LID - 10.3389/fpubh.2025.1539506 [doi] LID - 1539506 AB - BACKGROUND: Substantial scientific evidence firmly advocates consumption of vegetables and fruits for maintenance of overall health and protection against chronic diseases, such as obesity. However, prevalence of fruit and vegetable intake among adolescents in Malaysia remains low, whereas the data on factors associated with vegetable and fruit intake among adolescents were limited. OBJECTIVE: This study aims to determine the prevalence of fruit and vegetable intake and the factors that influence the Malaysian adolescents' consumption of fruits and vegetables. METHODS: A cross-sectional study was conducted from November 2021 to August 2022 by distribution of an online validated questionnaire on various platforms to recruit school-going adolescents aged 13 to 17 years old (Form 1-5) in Selangor. Respondents were screened and data of eligible participants were included as subjects. Descriptive statistics, chi square analysis, and generalized linear model with Poisson-loglinear distribution and the robust estimator were employed for data analysis. RESULTS: A total of 277 adolescents participated in this study. Overall, low prevalence of adequate vegetable consumption was observed (23.5%). Of the participants surveyed, 14.8% of adolescents with thinness, 25.2% and 15.0% of adolescents with overweight and obesity, and 27.1% of normal-weight adolescents met the recommended daily intake (>3 servings), whereas 64.1% of adolescents with overweight and obesity and 65% of normal-weight participants consumed at least two servings of fruits a day. The findings revealed significant association between BMI-for-age (X (2) ((1, N = 277)) = 5.236, p = 0.022) and adolescent fruit intake. On the other hand, overweight and obese adolescents reporting positive intention (PR: 1.146, 95% CI: 1.002, 1.310, p = 0.047) and parental allowance (PR: 1.125, 95% CI: 1.011, 1.252, p = 0.030) were observed to have 14.6% and 12.5% higher prevalence of fruit consumption, respectively, while availability at home (PR: 0.849, 95% CI: 0.731, 0.987, p = 0.033) showed significantly lower prevalence of fruit intake with more reports of home availability. CONCLUSION: The study suggests that personal, social-environmental, and physical-environmental factors influence vegetable and fruit intake among adolescents, particularly fruit intake consumption behaviors among overweight and obese adolescent population in Selangor. The enunciation of these intake correlates could potentially be incorporated in future development of intervention strategies to effectively promote fruit and vegetable intake. CI - Copyright (c) 2025 Shahridzal, Lau, Abd. Talib and Mohd Saat. FAU - Shahridzal, Shaliza A AU - Shahridzal SA AD - Centre for Community Health Studies (ReaCH), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. FAU - Lau, May Y AU - Lau MY AD - Centre for Community Health Studies (ReaCH), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. FAU - Abd Talib, Ruzita AU - Abd Talib R AD - Centre for Community Health Studies (ReaCH), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. AD - Nutritional Science Program, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. FAU - Mohd Saat, Nur Zakiah AU - Mohd Saat NZ AD - Program of Biomedical Sciences, Centre of Community Health (ReaCH), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. LA - eng PT - Journal Article DEP - 20250716 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Adolescent MH - *Fruit MH - *Vegetables MH - Female MH - Male MH - Cross-Sectional Studies MH - Malaysia/epidemiology MH - *Overweight/epidemiology MH - Surveys and Questionnaires MH - *Pediatric Obesity/epidemiology MH - *Feeding Behavior MH - *Diet/statistics & numerical data PMC - PMC12307182 OTO - NOTNLM OT - adolescents OT - factors OT - fruits OT - personal OT - physical-environmental OT - prevalence OT - social-environmental OT - vegetables COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/07/31 12:11 MHDA- 2025/07/31 12:12 PMCR- 2025/07/16 CRDT- 2025/07/31 05:26 PHST- 2024/12/04 00:00 [received] PHST- 2025/06/20 00:00 [accepted] PHST- 2025/07/31 12:12 [medline] PHST- 2025/07/31 12:11 [pubmed] PHST- 2025/07/31 05:26 [entrez] PHST- 2025/07/16 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1539506 [doi] PST - epublish SO - Front Public Health. 2025 Jul 16;13:1539506. doi: 10.3389/fpubh.2025.1539506. eCollection 2025. PMID- 40739224 OWN - NLM STAT- MEDLINE DCOM- 20250731 LR - 20250803 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Jul 30 TI - Beyond illness: how chronic conditions and unhealthy behaviors impact health-related quality of life among Iranian women. PG - 2591 LID - 10.1186/s12889-025-23977-6 [doi] LID - 2591 AB - BACKGROUND: Health-related quality of life (HRQoL) is a vital measure of overall well-being and is influenced by chronic conditions and unhealthy lifestyle behaviors. This study aimed to investigate the impact of chronic conditions and unhealthy behaviors on HRQoL among Iranian women aged 18 years and older. METHODS: A national cross-sectional study was conducted in 2024-2025 among 1,803 women from nine provinces in Iran using a convenience sampling method. Data were collected through face-to-face interviews using a structured questionnaire that included sociodemographic characteristics, lifestyle behaviors, chronic disease status, and the validated Iranian versions of the EQ-5D-5 L (hereafter referred to as EQ-5D) and EQ-VAS instruments to assess HRQoL. Given that the dependent variables (EQ-5D utility values and EQ-VAS scores) were not normally distributed and heteroscedasticity was detected, multivariable regression analyses were performed using a generalized linear model (GLM) with robust standard errors, adjusted age, marital status, level of education, place of birth, province, and self-assessed household economic status. RESULTS: Approximately 23.8% of participants reported at least one chronic condition. Women with chronic diseases had significantly lower EQ-5D index (mean = 0.62) and EQ-VAS scores (mean = 64.5) compared to those without (EQ-5D = 0.81, EQ-VAS = 76.1). Unhealthy behaviors, including poor physical activity, poor sleep quality, alcohol consumption, and smoking were all significantly associated with lower HRQoL scores (p-value < 0.05 in univariate analysis). Among these, poor sleep quality demonstrated the strongest negative association with both EQ-5D index and EQ-VAS scores. The GLM analyses indicated that chronic conditions and unhealthy behaviors, poor physical activity, poor sleep quality, and alcohol consumption were independently associated with significantly lower HRQoL after controlling for confounding factors. CONCLUSION: Chronic diseases and unhealthy lifestyle behaviors significantly diminish HRQoL among Iranian women. Public health interventions targeting these modifiable factors, especially improving sleep quality and promoting physical activity, are essential to enhance women's well-being in Iran and similar settings. CI - (c) 2025. The Author(s). FAU - Rezaei, Satar AU - Rezaei S AD - Research Center for Environmental Determinants of Health, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. satarrezaei@gmail.com. LA - eng PT - Journal Article DEP - 20250730 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - Iran/epidemiology MH - *Quality of Life/psychology MH - Cross-Sectional Studies MH - Adult MH - Chronic Disease/epidemiology/psychology MH - Middle Aged MH - Young Adult MH - *Health Behavior MH - Surveys and Questionnaires MH - Adolescent MH - Aged MH - Life Style PMC - PMC12308968 OTO - NOTNLM OT - Chronic diseases OT - EQ-5D-5L OT - Health-related quality of life OT - Iran OT - Unhealthy behaviors OT - Women's health COIS- Declarations. Ethics approval and consent to participate: The research protocol was approved by the Research Deputy of Kermanshah University of Medical Sciences, with the approval number IR.KUMS.REC.1403.337. The study adhered to the ethical principles outlined in the Declaration of Helsinki. Before data collection, the researchers provided a verbal explanation of the study's purpose to each potential participant, and informed consent was obtained from all subjects. Participants were also informed of their right to withdraw from the study at any time without facing any consequences. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. Conflict of interest: The author declares that there are no conflicts of interest. Note: Differences in the mean EQ-5D-5 L scores between chronic conditions and five unhealthy behaviors were examined using the Mann-Whitney U test. The analysis revealed that all comparisons were statistically significant, with p-values less than 0.05. *Significant at P < 0.001. Note: Differences in the mean EQ-VAS scores between chronic conditions and five unhealthy behaviors were examined using the Mann-Whitney U test. The analysis revealed that all comparisons were statistically significant, with p-values less than 0.05. *Significant at P < 0.001; **Significant at P < 0.05. Note: Some variables had missing data, which has resulted in the sum of categories being less than the total sample size of 3,518. Note: Result obtained from the Mann-Whitney U test. Note: The analyses for both models were adjusted for age, marital status, level of education, place of birth, province, and self-assessed household economic status. EDAT- 2025/07/31 00:29 MHDA- 2025/07/31 06:27 PMCR- 2025/07/30 CRDT- 2025/07/30 23:48 PHST- 2025/04/28 00:00 [received] PHST- 2025/07/14 00:00 [accepted] PHST- 2025/07/31 06:27 [medline] PHST- 2025/07/31 00:29 [pubmed] PHST- 2025/07/30 23:48 [entrez] PHST- 2025/07/30 00:00 [pmc-release] AID - 10.1186/s12889-025-23977-6 [pii] AID - 23977 [pii] AID - 10.1186/s12889-025-23977-6 [doi] PST - epublish SO - BMC Public Health. 2025 Jul 30;25(1):2591. doi: 10.1186/s12889-025-23977-6. PMID- 40738020 OWN - NLM STAT- MEDLINE DCOM- 20250823 LR - 20260612 IS - 1879-9825 (Electronic) IS - 1879-9817 (Linking) VI - 50 DP - 2025 Sep TI - Do the regions of the spinal column record stress differently? An analysis of diminished growth in the vertebral neural canal. PG - 81-90 LID - S1879-9817(25)00041-5 [pii] LID - 10.1016/j.ijpp.2025.07.004 [doi] AB - OBJECTIVE: This study explores the validity of the focus on lumbar vertebral neural canal (VNC) diameters as a non-specific stress indicator by comparing evidence of diminished growth between vertebral regions. MATERIALS: Cervical, thoracic, and lumbar VNC diameters were measured from 29 children (3-18 years) from the Certosa collection, a documented late 19th century skeletal assemblage. METHODS: Z-scores were calculated for each individual vertebra using published anterior-posterior (APD) and transverse (TRD) vertebral diameters obtained from radiographic images of living children. Differences in mean APD and TRD z-scores between vertebral regions were assessed using Repeated Measures ANOVA. RESULTS: Cervical TRD growth reduction was significantly greater than in the lumbar (p /= 3 symptoms had significantly higher IDA scores than those with none (mean rank difference = 217.5 vs. 69.8; p < 0.001), and WIFS scores (190.2 vs. 61.7; p < 0.001). Knowledge was significantly higher in older students (>/= 16 years vs. < 14 years: p < 0.001), higher grades (Standards 9 and 10 vs. Standard 8: p < 0.001), and those with literate parents (both p < 0.001). Boys had higher WIFS knowledge than girls (p < 0.001). CONCLUSION: Higher symptom burden and demographic factors were associated with greater knowledge, underscoring the need for focused anaemia education among less informed subgroups in school settings. CI - Copyright (c) 2025, Biswas et al. FAU - Biswas, Bijit AU - Biswas B AD - Community and Family Medicine, All India Institute of Medical Sciences, Deoghar, IND. FAU - Gautam, Anuradha AU - Gautam A AD - Community and Family Medicine, All India Institute of Medical Sciences, Deoghar, IND. FAU - Jahnavi, G AU - Jahnavi G AD - Community and Family Medicine, All India Institute of Medical Sciences, Deoghar, IND. FAU - Richa, Richa AU - Richa R AD - Community and Family Medicine, All India Institute of Medical Sciences, Deoghar, IND. FAU - Gupta, Pratima AU - Gupta P AD - Microbiology, All India Institute of Medical Sciences, Deoghar, IND. FAU - Varshney, Saurabh AU - Varshney S AD - Otolaryngology, All India Institute of Medical Sciences, Deoghar, IND. LA - eng PT - Journal Article DEP - 20250629 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC12306143 OTO - NOTNLM OT - adolescent OT - anaemia OT - iron deficiency OT - knowledge OT - school children OT - weekly iron and folic acid supplementation COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. All India Institute of Medical Sciences (AIIMS), Deoghar issued approval 2023-83-IND-02. Ethical approval was obtained from the Institutional Ethics Committee of All India Institute of Medical Sciences (AIIMS) Deoghar (Ref: 2023-83-IND-02). Written informed consent was collected from all participants. Administrative permissions were granted by the heads of participating schools. Confidentiality and anonymity were maintained throughout the study in accordance with the Declaration of Helsinki. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2025/07/30 11:11 MHDA- 2025/07/30 11:12 PMCR- 2025/06/29 CRDT- 2025/07/30 04:57 PHST- 2025/06/29 00:00 [accepted] PHST- 2025/07/30 11:12 [medline] PHST- 2025/07/30 11:11 [pubmed] PHST- 2025/07/30 04:57 [entrez] PHST- 2025/06/29 00:00 [pmc-release] AID - 10.7759/cureus.86955 [doi] PST - epublish SO - Cureus. 2025 Jun 29;17(6):e86955. doi: 10.7759/cureus.86955. eCollection 2025 Jun. PMID- 40732905 OWN - NLM STAT- MEDLINE DCOM- 20250730 LR - 20260925 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 14 DP - 2025 Jul 10 TI - Exploring Determinants of Mediterranean Lifestyle Adherence: Findings from the Multinational MEDIET4ALL e-Survey Across Ten Mediterranean and Neighboring Countries. LID - 10.3390/nu17142280 [doi] LID - 2280 AB - Background/Objectives: Despite its well-established health benefits, adherence to the Mediterranean lifestyle (MedLife) has declined globally, including in its region of origin, alongside a significant shift toward ultra-processed food consumption. Understanding the factors associated with MedLife adherence is essential for developing targeted interventions and tailored policy recommendations. As part of the MEDIET4ALL PRIMA project, this cross-sectional study aimed to comprehensively examine geo-demographic, socio-economic, psychological, behavioral, and barrier-related factors associated with and potentially contributing to MedLife adherence. Methods: Data were collected from 4010 participants aged 18 years and above across ten Mediterranean and neighboring countries using the multinational MEDIET4ALL e-survey, which included the validated MedLife index, along with various other questionnaires. Results: Results indicate that only 22% of respondents demonstrated high adherence to the Mediterranean lifestyle (MedLife), with significant variability observed across countries, age groups, education levels, and health statuses. Spain had the highest proportion of participants with high adherence (38%). Factors associated with significantly higher adherence rates include older age, living in the Mediterranean region, higher education levels, a greater awareness of MedLife principles, lower perceived barriers, normal BMI, better health status, and stable economic and marital conditions (p-values ranging from 0.04 to <0.001). Additionally, individuals with high MedLife adherence exhibited more socially and physically active lifestyles and experienced less psychological strain (p < 0.001). Regression analyses identified MedLife awareness as the strongest positive predictor of adherence (beta = 0.206), followed by social participation (beta = 0.194) and physical activity (beta = 0.096). Additional positive contributors include life satisfaction, sleep quality, living in the Mediterranean region, age, and education (beta ranging from 0.049 to 0.093). Conversely, factors that are negatively associated with adherence include sedentary behavior, living environment, and barriers such as low motivation, taste dislike, price unaffordability, limited availability, and the time-consuming nature of preparing Mediterranean food (MedFood; beta ranging from -0.036 to -0.067). Conclusions: These findings indicate that fewer than one in four adults across Mediterranean and neighboring countries demonstrate high adherence to MedLife, supporting prior evidence of suboptimal adherence even within Mediterranean regions. This study identified a range of behavioral, socio-demographic, and environmental factors-both positive and negative predictors-that can help guide the design of targeted, culturally adapted interventions to promote MedLife behavior. Future research should incorporate objective measurements and longitudinal monitoring to better understand underlying mechanisms, establish causality, and develop sustainable strategies for enhancing MedLife adherence in diverse populations. FAU - Ammar, Achraf AU - Ammar A AUID- ORCID: 0000-0003-0347-8053 AD - Department of Training and Movement Science, Institute of Sport Science, Johannes Gutenberg-University Mainz, 55122 Mainz, Germany. AD - Research Laboratory, Molecular Bases of Human Pathology, LR19ES13, Faculty of Medicine of Sfax, University of Sfax, Sfax 3000, Tunisia. AD - High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax 3000, Tunisia. AD - Department of Movement Sciences and Sports Training, School of Sport Science, The University of Jordan, Amman 11942, Jordan. FAU - Boujelbane, Mohamed Ali AU - Boujelbane MA AD - Department of Training and Movement Science, Institute of Sport Science, Johannes Gutenberg-University Mainz, 55122 Mainz, Germany. AD - High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax 3000, Tunisia. FAU - Salem, Atef AU - Salem A AD - Department of Training and Movement Science, Institute of Sport Science, Johannes Gutenberg-University Mainz, 55122 Mainz, Germany. AD - High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax 3000, Tunisia. FAU - Trabelsi, Khaled AU - Trabelsi K AUID- ORCID: 0000-0003-2623-9557 AD - Department of Movement Sciences and Sports Training, School of Sport Science, The University of Jordan, Amman 11942, Jordan. AD - Research Laboratory: Education, Motricity, Sport and Health, EM2S, LR19JS01, High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax 3000, Tunisia. FAU - Bouaziz, Bassem AU - Bouaziz B AUID- ORCID: 0000-0002-3692-9482 AD - Multimedia Information Systems and Advanced Computing Laboratory (MIRACL), University of Sfax, Sfax 3021, Tunisia. AD - Higher Institute of Information Science and Multimedia of Sfax (ISIMS), University of Sfax, Sfax 3021, Tunisia. FAU - Kerkeni, Mohamed AU - Kerkeni M AUID- ORCID: 0009-0002-2463-9004 AD - High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax 3000, Tunisia. AD - Research Laboratory: Education, Motricity, Sport and Health, EM2S, LR19JS01, High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax 3000, Tunisia. FAU - Masmoudi, Liwa AU - Masmoudi L AD - High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax 3000, Tunisia. FAU - Heydenreich, Juliane AU - Heydenreich J AUID- ORCID: 0000-0002-7346-4872 AD - Department of Experimental Sports Nutrition, Faculty of Sports Sciences, Leipzig University, 04109 Leipzig, Germany. FAU - Schallhorn, Christiana AU - Schallhorn C AUID- ORCID: 0000-0003-1564-2658 AD - Department of Sports Economics, Sociology and History, Institute of Sport Science, Johannes Gutenberg-University Mainz, 55122 Mainz, Germany. FAU - Muller, Gabriel AU - Muller G AUID- ORCID: 0009-0009-6405-0916 AD - Department of Training and Movement Science, Institute of Sport Science, Johannes Gutenberg-University Mainz, 55122 Mainz, Germany. FAU - Uyar, Ayse Merve AU - Uyar AM AD - Department of Training and Movement Science, Institute of Sport Science, Johannes Gutenberg-University Mainz, 55122 Mainz, Germany. FAU - Ghazzawi, Hadeel Ali AU - Ghazzawi HA AUID- ORCID: 0000-0003-3045-4153 AD - Department of Nutrition and Food Technology, School of Agriculture, The University of Jordan, Amman 11942, Jordan. FAU - Amawi, Adam Tawfiq AU - Amawi AT AD - Department of Movement Sciences and Sports Training, School of Sport Science, The University of Jordan, Amman 11942, Jordan. FAU - Orhan, Bekir Erhan AU - Orhan BE AUID- ORCID: 0000-0002-3149-6630 AD - Faculty of Sports Sciences, Istanbul Aydin University, 34295 Istanbul, Turkey. FAU - Grosso, Giuseppe AU - Grosso G AD - Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy. FAU - Abdelkarim, Osama AU - Abdelkarim O AD - Faculty of Sport Sciences, Assiut University, Assiut 71515, Egypt. AD - ESLSCA University Egypt, Giza 12676, Egypt. FAU - Aly, Mohamed AU - Aly M AUID- ORCID: 0000-0002-8025-2210 AD - Faculty of Sport Sciences, Assiut University, Assiut 71515, Egypt. AD - ESLSCA University Egypt, Giza 12676, Egypt. FAU - Driss, Tarak AU - Driss T AUID- ORCID: 0000-0001-6109-7393 AD - Interdisciplinary Laboratory in Neurosciences, Physiology, and Psychology: Physical Activity, Health, and Learning (LINP2), UFR STAPS, Paris Nanterre University, 92000 Nanterre, France. FAU - El Abed, Kais AU - El Abed K AD - High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax 3000, Tunisia. AD - Research Laboratory: Education, Motricity, Sport and Health, EM2S, LR19JS01, High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax 3000, Tunisia. FAU - Moalla, Wassim AU - Moalla W AUID- ORCID: 0000-0001-6358-2544 AD - High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax 3000, Tunisia. AD - Research Laboratory: Education, Motricity, Sport and Health, EM2S, LR19JS01, High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax 3000, Tunisia. FAU - Zmijewski, Piotr AU - Zmijewski P AUID- ORCID: 0000-0002-5570-9573 AD - Department of Biomedical Sciences, Jozef Pilsudski University of Physical Education in Warsaw, 00-968 Warsaw, Poland. FAU - Debeaufort, Frederic AU - Debeaufort F AUID- ORCID: 0000-0002-4760-0500 AD - Department BioEngineering, Institut Universitaire de Technologie IUT-Dijon, Universite Bougogne Europe, Blvd Dr. Petitjean, CEDEX, 21078 Dijon, France. AD - Joint Research Unit UMR PAM-PCAV (Physical-Chemistry of Food and Wine Laboratory), Universite Bourgogne Europe/Institut AgroDijon/INRAE, 1 Esplanade Erasme, 21000 Dijon, France. FAU - Benbettaieb, Nasreddine AU - Benbettaieb N AD - Department BioEngineering, Institut Universitaire de Technologie IUT-Dijon, Universite Bougogne Europe, Blvd Dr. Petitjean, CEDEX, 21078 Dijon, France. AD - Joint Research Unit UMR PAM-PCAV (Physical-Chemistry of Food and Wine Laboratory), Universite Bourgogne Europe/Institut AgroDijon/INRAE, 1 Esplanade Erasme, 21000 Dijon, France. FAU - Poulain, Clement AU - Poulain C AUID- ORCID: 0009-0004-6370-1581 AD - Department BioEngineering, Institut Universitaire de Technologie IUT-Dijon, Universite Bougogne Europe, Blvd Dr. Petitjean, CEDEX, 21078 Dijon, France. AD - Joint Research Unit UMR PAM-PCAV (Physical-Chemistry of Food and Wine Laboratory), Universite Bourgogne Europe/Institut AgroDijon/INRAE, 1 Esplanade Erasme, 21000 Dijon, France. FAU - Reyes, Laura AU - Reyes L AD - Vitagora Innovation Cluster, 21000 Dijon, France. FAU - Gamero, Amparo AU - Gamero A AUID- ORCID: 0000-0002-7226-4844 AD - Department of Preventive Medicine and Public Health, Food Science, Toxicology and Forensic Medicine, Faculty of Pharmacy & Food Sciences, University of Valencia, 46100 Valencia, Spain. FAU - Cuenca-Ortola, Marta AU - Cuenca-Ortola M AD - Department of Preventive Medicine and Public Health, Food Science, Toxicology and Forensic Medicine, Faculty of Pharmacy & Food Sciences, University of Valencia, 46100 Valencia, Spain. FAU - Cilla, Antonio AU - Cilla A AUID- ORCID: 0000-0001-6532-9032 AD - Department of Preventive Medicine and Public Health, Food Science, Toxicology and Forensic Medicine, Faculty of Pharmacy & Food Sciences, University of Valencia, 46100 Valencia, Spain. FAU - Francesca, Nicola AU - Francesca N AUID- ORCID: 0000-0002-6063-0130 AD - Department of Agricultural Food and Forest Sciences, University of Palermo, Viale delle Scienze, 90128 Palermo, Italy. FAU - Messina, Concetta Maria AU - Messina CM AUID- ORCID: 0000-0003-3190-9420 AD - Laboratory of Marine Biochemistry and Ecotoxicology, Department of Earth and Marine Sciences DiSTeM, University of Palermo, Via Barlotta 4, 91100 Trapani, Italy. FAU - Viola, Enrico AU - Viola E AD - Department of Agricultural Food and Forest Sciences, University of Palermo, Viale delle Scienze, 90128 Palermo, Italy. FAU - Lorenzen, Bjorn AU - Lorenzen B AD - Microtarians Academy, 1746 Luxembourg, Luxembourg. FAU - Filice, Stefania AU - Filice S AD - Microtarians Academy, 1746 Luxembourg, Luxembourg. FAU - Bajoub, Aadil AU - Bajoub A AD - Laboratory of Food and Food By-Products Chemistry and Processing Technology, National School of Agriculture in Meknes, km 10, Haj Kaddour Road, B.P. S/40, Meknes 50001, Morocco. FAU - Ajal, El-Mehdi AU - Ajal EM AD - Laboratory of Food and Food By-Products Chemistry and Processing Technology, National School of Agriculture in Meknes, km 10, Haj Kaddour Road, B.P. S/40, Meknes 50001, Morocco. AD - Laboratory of Social Medicine, Department of Epidemiology and Public Health, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat 10100, Morocco. FAU - Ajal, El Amine AU - Ajal EA AD - UPR of Pharmacognosy, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat 10100, Morocco. FAU - Obtel, Majdouline AU - Obtel M AD - Laboratory of Social Medicine, Department of Epidemiology and Public Health, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat 10100, Morocco. FAU - Lahiani, Sadjia AU - Lahiani S AD - VALCORE Laboratory, Department of Biology, Faculty of Science, University of M'hamed Bougara Boumerdes, Boumerdes 35000, Algeria. FAU - Khaldi, Taha AU - Khaldi T AUID- ORCID: 0000-0003-2514-0897 AD - Biotechnology Research Center CRBt, Constantine 25000, Algeria. FAU - Souissi, Nafaa AU - Souissi N AUID- ORCID: 0009-0005-5225-9203 AD - Research Laboratory, Molecular Bases of Human Pathology, LR19ES13, Faculty of Medicine of Sfax, University of Sfax, Sfax 3000, Tunisia. AD - High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax 3000, Tunisia. FAU - Boukhris, Omar AU - Boukhris O AD - SIESTA Research Group, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne 3086, Australia. AD - Sport, Performance, and Nutrition Research Group, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne 3086, Australia. FAU - Husain, Waqar AU - Husain W AUID- ORCID: 0000-0003-3047-1834 AD - Department of Humanities, COMSATS University Islamabad, Islamabad Campus, Park Road, Islamabad 45550, Pakistan. FAU - Frias-Toral, Evelyn AU - Frias-Toral E AUID- ORCID: 0000-0002-2228-0141 AD - Escuela de Medicina, Universidad Espiritu Santo, Samborondon 0901952, Ecuador. AD - Division of Research, Texas State University, 601 University Dr, San Marcos, TX 78666, USA. FAU - Mahdi, Walid AU - Mahdi W AD - Multimedia Information Systems and Advanced Computing Laboratory (MIRACL), University of Sfax, Sfax 3021, Tunisia. AD - Higher Institute of Information Science and Multimedia of Sfax (ISIMS), University of Sfax, Sfax 3021, Tunisia. FAU - Chtourou, Hamdi AU - Chtourou H AUID- ORCID: 0000-0002-5482-9151 AD - High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax 3000, Tunisia. AD - Research Unit, Physical Activity, Sport, and Health, UR18JS01, National Observatory of Sport, Tunis 1003, Tunisia. FAU - Jahrami, Haitham AU - Jahrami H AUID- ORCID: 0000-0001-8990-1320 AD - Government Hospitals, Manama P.O. Box 12, Bahrain. AD - Department of Psychiatry, College of Medicine and Health Sciences, Arabian Gulf University, Manama P.O. Box 26671, Bahrain. FAU - Schollhorn, Wolfgang I AU - Schollhorn WI AUID- ORCID: 0000-0002-4558-1991 AD - Department of Training and Movement Science, Institute of Sport Science, Johannes Gutenberg-University Mainz, 55122 Mainz, Germany. LA - eng GR - 02WPM1681/Federal Ministry of Education and Research/ PT - Journal Article DEP - 20250710 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Male MH - Middle Aged MH - Adult MH - Cross-Sectional Studies MH - *Diet, Mediterranean/statistics & numerical data/psychology MH - Aged MH - Young Adult MH - Mediterranean Region MH - Surveys and Questionnaires MH - *Healthy Lifestyle MH - Adolescent MH - Socioeconomic Factors MH - Life Style MH - Exercise MH - *Patient Compliance/statistics & numerical data PMC - PMC12299240 OTO - NOTNLM OT - Mediterranean diet OT - active lifestyle OT - engagement OT - exercise OT - food OT - food literacy OT - multicenter study OT - nutrition knowledge OT - public health OT - socialization COIS- Authors Bjorn Lorenzen and Stefania Filice were employed by the company Microtarians Academy. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/07/30 06:30 MHDA- 2025/07/30 06:31 PMCR- 2025/07/10 CRDT- 2025/07/30 01:12 PHST- 2025/05/20 00:00 [received] PHST- 2025/07/04 00:00 [revised] PHST- 2025/07/08 00:00 [accepted] PHST- 2025/07/30 06:31 [medline] PHST- 2025/07/30 06:30 [pubmed] PHST- 2025/07/30 01:12 [entrez] PHST- 2025/07/10 00:00 [pmc-release] AID - nu17142280 [pii] AID - nutrients-17-02280 [pii] AID - 10.3390/nu17142280 [doi] PST - epublish SO - Nutrients. 2025 Jul 10;17(14):2280. doi: 10.3390/nu17142280. PMID- 40732892 OWN - NLM STAT- MEDLINE DCOM- 20250730 LR - 20250802 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 14 DP - 2025 Jul 9 TI - Does Intergenerational Care Increase Sugar-Sweetened Beverage Consumption of Schoolchildren? Evidence from CEPS Data in China. LID - 10.3390/nu17142267 [doi] LID - 2267 AB - Background/Objectives: Intergenerational care plays a significant role in shaping household dietary quality and human capital development in China. Influenced by the legacy of the one-child policy, the care provided in these families often prioritizes child-focused practices. This study examines how intergenerational care influences schoolchildren's sugar-sweetened beverage (SSB) consumption. Methods: This study utilizes data from the 2014-2015 China Education Panel Survey (CEPS) to investigate the impact of intergenerational care on schoolchildren's dietary behaviors, with a focus on sugar-sweetened beverage (SSB) consumption. We apply both ordinary least squares (OLS) regression and the ordered logit model to estimate the impacts, and we use the instrumental variables approach to address potential endogeneity. Results: Schoolchildren from only-child families report greater SSB consumption, while those from multi-child families consume less. Intergenerational care is linked to more digital media exposure, more pocket money, and less parental supervision. These findings withstand rigorous validation through multiple robustness checks, including sample restriction strategies and propensity score matching (PSM) analysis. The effect is especially pronounced among boys, schoolchildren from families with higher parental education levels, and schoolchildren attending schools without formal nutrition education programs. Conclusions: The result indicates that intergenerational care significantly increases SSB consumption among schoolchildren from only-child families. Community nutrition and school health education programs can reduce schoolchildren's SSB consumption, thereby lowering risks of obesity and other public health concerns. FAU - Feng, Manjing AU - Feng M AD - College of Economics & Management, Northwest A&F University, Yangling 712100, China. FAU - Liu, Qi AU - Liu Q AD - College of Economics & Management, Northwest A&F University, Yangling 712100, China. FAU - Du, Dekun AU - Du D AD - College of Economics & Management, Northwest A&F University, Yangling 712100, China. FAU - Ren, Yanjun AU - Ren Y AUID- ORCID: 0000-0002-8384-8925 AD - College of Economics & Management, Northwest A&F University, Yangling 712100, China. LA - eng GR - QCYRCXM-2022-145/the Qinchuangyuan Project of Shaanxi Province/ GR - 72373117/the National Natural Science Foundation of China/ GR - 22JJD790052/the Major project of the Key Research Base of Humanities and Social Sciences of the Ministry of Education/ GR - Z1010422003/the Chinese Universities Scientific Fund/ PT - Journal Article DEP - 20250709 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Sugar-Sweetened Beverages/statistics & numerical data MH - Male MH - China MH - Female MH - Child MH - *Intergenerational Relations MH - *Feeding Behavior MH - Adolescent PMC - PMC12298230 OTO - NOTNLM OT - China OT - consumption OT - intergenerational care OT - sugar-sweetened beverages COIS- The authors declare no conflicts of interest. EDAT- 2025/07/30 06:30 MHDA- 2025/07/30 06:31 PMCR- 2025/07/09 CRDT- 2025/07/30 01:12 PHST- 2025/05/20 00:00 [received] PHST- 2025/06/24 00:00 [revised] PHST- 2025/07/05 00:00 [accepted] PHST- 2025/07/30 06:31 [medline] PHST- 2025/07/30 06:30 [pubmed] PHST- 2025/07/30 01:12 [entrez] PHST- 2025/07/09 00:00 [pmc-release] AID - nu17142267 [pii] AID - nutrients-17-02267 [pii] AID - 10.3390/nu17142267 [doi] PST - epublish SO - Nutrients. 2025 Jul 9;17(14):2267. doi: 10.3390/nu17142267. PMID- 40732591 OWN - NLM STAT- MEDLINE DCOM- 20250730 LR - 20250802 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 25 IP - 14 DP - 2025 Jul 17 TI - Agreement Between a Pre-Markered T-Shirt and Manual Marker Placement for Opto-Electronic Plethysmography (OEP) Measures. LID - 10.3390/s25144464 [doi] LID - 4464 AB - Opto-electronic plethysmography (OEP) is used to measure chest wall compartment volumes and their synchronisation. Breathing pattern disorder (BPD) can be distinguished using the phase angles between these chest wall compartments during exercise. However, the time taken to manually place the standard OEP model involving 89 reflective markers is high during clinical application. The purpose of this study was to investigate the use of a pre-markered T-shirt instead of markers applied directly to the skin at rest, during different exercise intensities and recovery. Thirty-nine healthy participants (24 male, 15 female) aged 18-40 years performed an incremental cycling test with the skin-mounted OEP marker set. Participants then repeated the same cycling test with a pre-markered T-shirt. Across all test conditions, the T-shirt showed a strong level of agreement (Intraclass correlation coefficient (ICC) >/= 0.9) with the standard breath-by-breath (BbB) gas analyser. Moreover, ICC values exceeded 0.8 for compartment contributions across all test conditions, indicating excellent agreement with the skin-mounted markers. The phase angles between compartments showed the best agreement during the moderate exercise level (0.6 < ICC < 0.8). In conclusion, the pre-markered T-shirt presents a viable solution for the quick monitoring of breathing patterns, as well as an effective tool in diagnosing BPD during exercise. FAU - Adhikari, Nayani G AU - Adhikari NG AUID- ORCID: 0009-0009-9968-2702 AD - School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK. AD - Population Health Research Institute, City St George's, University of London, London SW17 0RE, UK. FAU - Hunsicker, Eugenie AU - Hunsicker E AD - Department of Mathematical Sciences, Loughborough University, Loughborough LE11 3TU, UK. FAU - Pain, Matthew T G AU - Pain MTG AUID- ORCID: 0000-0002-0028-2365 AD - School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK. FAU - Dickinson, John W AU - Dickinson JW AUID- ORCID: 0000-0002-1824-7402 AD - School of Sport and Exercise Sciences, University of Kent, Canterbury CT2 7NZ, UK. FAU - Winter, Samantha L AU - Winter SL AUID- ORCID: 0000-0001-7450-1105 AD - School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK. LA - eng PT - Journal Article DEP - 20250717 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - Male MH - Female MH - *Plethysmography/methods/instrumentation MH - Adult MH - Adolescent MH - Young Adult MH - Exercise/physiology MH - Respiration MH - *Clothing MH - Thoracic Wall/physiology MH - Exercise Test PMC - PMC12300466 OTO - NOTNLM OT - breathing pattern disorder OT - motion capture technique OT - opto-electronic plethysmography OT - phase angle OT - tidal volume COIS- The authors declare no conflicts of interest. EDAT- 2025/07/30 06:29 MHDA- 2025/07/30 06:30 PMCR- 2025/07/17 CRDT- 2025/07/30 01:11 PHST- 2025/06/04 00:00 [received] PHST- 2025/07/04 00:00 [revised] PHST- 2025/07/15 00:00 [accepted] PHST- 2025/07/30 06:30 [medline] PHST- 2025/07/30 06:29 [pubmed] PHST- 2025/07/30 01:11 [entrez] PHST- 2025/07/17 00:00 [pmc-release] AID - s25144464 [pii] AID - sensors-25-04464 [pii] AID - 10.3390/s25144464 [doi] PST - epublish SO - Sensors (Basel). 2025 Jul 17;25(14):4464. doi: 10.3390/s25144464. PMID- 40731855 OWN - NLM STAT- MEDLINE DCOM- 20250730 LR - 20250801 IS - 1648-9144 (Electronic) IS - 1010-660X (Print) IS - 1010-660X (Linking) VI - 61 IP - 7 DP - 2025 Jul 6 TI - Disordered Eating Behaviors, Perceived Stress and Insomnia During Academic Exams: A Study Among University Students. LID - 10.3390/medicina61071226 [doi] LID - 1226 AB - Background and Objectives: During exam sessions, many students experience high levels of stress caused by the large volume of material to study, tight deadlines, and pressure to achieve top grades. This study aimed to examine the relationship between academic stress, sleep disturbances, and eating behaviors by using validated questionnaires administered to a student sample. As stress levels increased, the data revealed a higher frequency of insomnia symptoms and disordered eating, including behaviors such as compulsive eating and irregular meal patterns. Materials and Methods: This cross-sectional, correlational study was conducted on a convenience sample of 317 university students from various academic centers across Romania. Participants were recruited via online distribution of a self-administered questionnaire during a four-month period, including exam sessions. The survey included the Perceived Stress Scale (PSS), the Insomnia Severity Index (ISI), and the Eating Disorder Examination Questionnaire (EDE-Q), alongside additional items assessing perceived links between stress, sleep, and eating behaviors, and the use of medication. Data were analyzed using SPSS with Spearman correlations, t-tests, and linear regression. Results: Statistical analyses revealed significant and positive associations between perceived stress levels and insomnia, as indicated by Spearman's correlation (p < 0.01). A similar significant correlation was identified between perceived stress and disordered eating behaviors among students. Specifically, the feeling of being overwhelmed by academic workload showed a strong positive correlation with a lack of control over eating behaviors (r = 0.568). Furthermore, linear regression analysis confirmed a significant predictive relationship between feeling overwhelmed and the tendency to eat excessively beyond initial intentions, with a standardized regression coefficient B = 0.581 (p < 0.001). A separate regression analysis focusing on exam-related stress and episodes of compulsive eating behavior demonstrated a comparable result (B = 0.573, p < 0.001), indicating a robust positive association. Additionally, independent samples t-tests demonstrated that students experiencing high levels of stress during the exam period reported significantly greater difficulties with sleep initiation and higher levels of disordered eating compared to their peers with lower stress levels. The difference in insomnia scores was highly significant (t = 11.516, p < 0.001), as was the difference in eating behavior scores (t = 10.931, p < 0.001). Conclusions: These findings underscore the need for emotional support services and effective stress management strategies, enabling students to navigate academic demands without compromising their mental or physical well-being. FAU - Strete, Elena-Gabriela AU - Strete EG AUID- ORCID: 0000-0003-2963-6793 AD - Department of Psychiatry, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania. FAU - Cincu, Madalina-Gabriela AU - Cincu MG AD - Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania. FAU - Salcudean, Andreea AU - Salcudean A AD - Department of Ethics and Social Sciences, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania. LA - eng PT - Journal Article DEP - 20250706 PL - Switzerland TA - Medicina (Kaunas) JT - Medicina (Kaunas, Lithuania) JID - 9425208 SB - IM MH - Humans MH - Female MH - Male MH - *Sleep Initiation and Maintenance Disorders/psychology/etiology/complications/epidemiology MH - Cross-Sectional Studies MH - Universities/organization & administration/statistics & numerical data MH - *Stress, Psychological/psychology/complications MH - *Students/psychology/statistics & numerical data MH - *Feeding and Eating Disorders/psychology/complications/etiology/epidemiology MH - Surveys and Questionnaires MH - Adult MH - Romania/epidemiology MH - *Perception MH - Young Adult MH - Feeding Behavior/psychology MH - Educational Measurement/methods/statistics & numerical data MH - Adolescent PMC - PMC12300404 OTO - NOTNLM OT - academic stress OT - eating behaviors OT - exams OT - insomnia OT - students OT - university COIS- The authors declare no conflicts of interest. EDAT- 2025/07/30 06:30 MHDA- 2025/07/30 06:31 PMCR- 2025/07/06 CRDT- 2025/07/30 01:04 PHST- 2025/06/09 00:00 [received] PHST- 2025/07/03 00:00 [revised] PHST- 2025/07/04 00:00 [accepted] PHST- 2025/07/30 06:31 [medline] PHST- 2025/07/30 06:30 [pubmed] PHST- 2025/07/30 01:04 [entrez] PHST- 2025/07/06 00:00 [pmc-release] AID - medicina61071226 [pii] AID - medicina-61-01226 [pii] AID - 10.3390/medicina61071226 [doi] PST - epublish SO - Medicina (Kaunas). 2025 Jul 6;61(7):1226. doi: 10.3390/medicina61071226. PMID- 40731268 OWN - NLM STAT- MEDLINE DCOM- 20250730 LR - 20250801 IS - 1471-2407 (Electronic) IS - 1471-2407 (Linking) VI - 25 IP - 1 DP - 2025 Jul 29 TI - Risk factor analysis and predictive model development for secondary failure of platelet recovery following allogeneic hematopoietic stem cell transplantation. PG - 1233 LID - 10.1186/s12885-025-14653-4 [doi] LID - 1233 AB - Secondary failure of platelet recovery (SFPR) is a common complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT), occurring in approximately 20% of cases, and is closely associated with poor patient prognosis. The purpose of this study is to analyze the risk factors associated with SFPR following allo-HSCT, develop a nomogram-based predictive model for SFPR, and validate its accuracy. Clinical data of patients who underwent allo-HSCT in the Department of Hematology at the First Hospital of Lanzhou University from January 2016 to December 2023 were collected. Variables with P < 0.05 in univariate analysis were included in a logistic multivariate stepwise regression to identify the final variables for the model. An SFPR nomogram prediction model was developed using R software and internally validated using the Bootstrap method. The accuracy of the prediction model was assessed through receiver operating characteristic(ROC) and calibration curves, while decision curve analysis evaluated its clinical predictive performance. Based on the body mass index(BMI), chromosome karyotype, transplant type, acute graft-versus-host disease(aGVHD) and post-transplant Interleukin-6(IL-6) and Procalcitonin(PCT), the predicted area under the ROC curve of SFPR is 0.778 (95% CI 0.697-0.858). The absolute error between the predicted risk of SFPR and the actual risk is 0.019. The SFPR nomogram prediction model developed in this study exhibits high accuracy and excellent predictive efficiency, thereby possessing significant clinical guidance value. CI - (c) 2025. The Author(s). FAU - Peng, Xiru AU - Peng X AD - The First Clinical Medical College of Lanzhou University, Lanzhou, China. FAU - Cheng, Juan AU - Cheng J AD - The First Clinical Medical College of Lanzhou University, Lanzhou, China. Chenggu029@163.com. AD - Department of Hematology, The First Hospital of Lanzhou University, Lanzhou, China. Chenggu029@163.com. LA - eng GR - (23)0379/Analysis of the Efficacy and Safety of Azacitidine in Maintenance Therapy for Acute Myeloid Leukemia/ GR - (23)0379/Analysis of the Efficacy and Safety of Azacitidine in Maintenance Therapy for Acute Myeloid Leukemia/ PT - Journal Article DEP - 20250729 PL - England TA - BMC Cancer JT - BMC cancer JID - 100967800 RN - 0 (Interleukin-6) SB - IM MH - Humans MH - *Hematopoietic Stem Cell Transplantation/adverse effects MH - Female MH - Male MH - Risk Factors MH - Adult MH - Nomograms MH - Middle Aged MH - Transplantation, Homologous/adverse effects MH - *Graft vs Host Disease/etiology/blood MH - ROC Curve MH - Adolescent MH - Young Adult MH - Retrospective Studies MH - Prognosis MH - *Blood Platelets MH - Interleukin-6/blood PMC - PMC12309133 OTO - NOTNLM OT - Allogeneic hematopoietic stem cell transplantation OT - Nomogram OT - Prediction model OT - Risk factors OT - Secondary failure of platelet recovery COIS- Declarations. Ethics approval and consent to participate: The studies involving human participants were reviewed and approved by the Center for Ethics in the First Hospital of Lanzhou University. Written informed consent was obtained from patient for the publication of any potentially identifiable images or data included in this article. Competing interests: The authors declare no competing interests. EDAT- 2025/07/30 06:28 MHDA- 2025/07/30 06:29 PMCR- 2025/07/29 CRDT- 2025/07/30 00:30 PHST- 2025/03/31 00:00 [received] PHST- 2025/07/08 00:00 [accepted] PHST- 2025/07/30 06:29 [medline] PHST- 2025/07/30 06:28 [pubmed] PHST- 2025/07/30 00:30 [entrez] PHST- 2025/07/29 00:00 [pmc-release] AID - 10.1186/s12885-025-14653-4 [pii] AID - 14653 [pii] AID - 10.1186/s12885-025-14653-4 [doi] PST - epublish SO - BMC Cancer. 2025 Jul 29;25(1):1233. doi: 10.1186/s12885-025-14653-4. PMID- 40731156 OWN - NLM STAT- MEDLINE DCOM- 20260108 LR - 20261009 IS - 1476-5640 (Electronic) IS - 0954-3007 (Linking) VI - 80 IP - 1 DP - 2026 Jan TI - An RFH-NPT-based nomogram for predicting the long-term survival of liver cirrhosis patients: a multicenter study. PG - 87-95 LID - 10.1038/s41430-025-01648-4 [doi] AB - BACKGROUND AND AIMS: The Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT) identifies nutritional risk in patients with liver disease, an important factor in cirrhosis outcomes. Recognizing the gap in existing prognostic models, which often overlook malnutrition, we developed and validated an RFH-NPT-based model for predicting outcomes of patients with cirrhosis. METHODS: This study included inpatients with cirrhosis from a single center between February and July 2016 (training cohort) and patients from six other medical centers admitted between December 2011 and May 2022 (validation cohort). RFH-NPT assessment was conducted at admission, followed by a 5-year follow-up. A nomogram was created using prognostic variables from Cox modeling, best subset regression (BSR), and least absolute shrinkage and selection operator (LASSO) regression. Its performance was evaluated using various statistical methods and compared with that of existing models such as the Child‒Pugh, MELD, and MELD-Na. RESULTS: A total of 152 patients were included in the training cohort. The nutritional risk was significantly greater in nonsurvivors (81.1%) than in survivors (46.5%). The nomogram showed better accuracy in predicting 1-, 3-, and 5-year survival than traditional methods. The nomogram's effectiveness was confirmed in the validation cohort of 320 patients. CONCLUSION: This study re-emphasizes the critical role of malnutrition in patients with liver cirrhosis and establishes an effective RFH-NPT-based model for outcome prediction. CLINICAL TRIAL REGISTRATION: This study is registered at Clinicaltrials.gov (NCT05513651). CI - (c) 2025. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Zhu, Chengbin AU - Zhu C AD - Department of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Institution of Hepatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Shaanxi Clinical Medical Research Center of Infectious Diseases, Xi'an, Shaanxi, China. AD - Clinical Research Center for Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. FAU - Wu, Yuchao AU - Wu Y AUID- ORCID: 0000-0003-4823-9507 AD - Department of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Institution of Hepatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Shaanxi Clinical Medical Research Center of Infectious Diseases, Xi'an, Shaanxi, China. AD - Clinical Research Center for Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Department of Radiation Oncology, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China. FAU - Zhao, Fulian AU - Zhao F AD - Department of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Institution of Hepatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Shaanxi Clinical Medical Research Center of Infectious Diseases, Xi'an, Shaanxi, China. AD - Clinical Research Center for Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. FAU - Wang, Ruojing AU - Wang R AD - Department of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Institution of Hepatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Shaanxi Clinical Medical Research Center of Infectious Diseases, Xi'an, Shaanxi, China. AD - Clinical Research Center for Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. FAU - Zang, Qijuan AU - Zang Q AUID- ORCID: 0000-0003-1431-5102 AD - Department of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Institution of Hepatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Shaanxi Clinical Medical Research Center of Infectious Diseases, Xi'an, Shaanxi, China. AD - Clinical Research Center for Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. FAU - Jiao, Zhe AU - Jiao Z AD - Department of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Institution of Hepatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Shaanxi Clinical Medical Research Center of Infectious Diseases, Xi'an, Shaanxi, China. AD - Clinical Research Center for Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. FAU - Zhu, Yage AU - Zhu Y AD - Department of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Institution of Hepatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Shaanxi Clinical Medical Research Center of Infectious Diseases, Xi'an, Shaanxi, China. AD - Clinical Research Center for Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. FAU - Yan, Taotao AU - Yan T AD - Department of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Institution of Hepatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Shaanxi Clinical Medical Research Center of Infectious Diseases, Xi'an, Shaanxi, China. AD - Clinical Research Center for Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. FAU - Du, Juan AU - Du J AD - Department of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Institution of Hepatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Shaanxi Clinical Medical Research Center of Infectious Diseases, Xi'an, Shaanxi, China. AD - Clinical Research Center for Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. FAU - Zhu, Li AU - Zhu L AD - Department of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Institution of Hepatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Shaanxi Clinical Medical Research Center of Infectious Diseases, Xi'an, Shaanxi, China. AD - Clinical Research Center for Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. FAU - Li, Weimin AU - Li W AD - Department of Clinical Nutrition, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. FAU - Li, Yongqin AU - Li Y AD - Department of Infectious Diseases, Xi'an Central Hospital, Xi'an, Shaanxi, China. FAU - Fan, Qing AU - Fan Q AD - Department of Infectious Diseases, Huazhou People's Hospital, Weinan, Shannxi, China. FAU - Wu, Anping AU - Wu A AD - Department of Infectious Diseases, Huazhou People's Hospital, Weinan, Shannxi, China. FAU - Liu, Xiaodan AU - Liu X AD - Department of Infectious Diseases, Shiquan County Hospital, Ankang, Shannxi, China. FAU - Liu, Dianzu AU - Liu D AD - Department of Infectious Diseases, Hanzhong Central Hospital, Hanzhong, Shannxi, China. FAU - Tang, Xianmei AU - Tang X AD - Department of Infectious Diseases, Hanzhong Central Hospital, Hanzhong, Shannxi, China. FAU - Xu, Xiaoxiao AU - Xu X AD - Department of Infectious Diseases, Second People's Hospital of Dingxi, Dingxi, Gansu, China. FAU - Liao, Huaying AU - Liao H AD - Department of Radiation Oncology, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China. FAU - Li, Yu AU - Li Y AD - Department of Infectious Diseases, Shaanxi Provincial People's Hospital, Xi'an, Shannxi, China. FAU - Zhao, Yingren AU - Zhao Y AD - Department of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. zhaoyingren@xjtu.edu.cn. AD - Institution of Hepatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. zhaoyingren@xjtu.edu.cn. AD - Shaanxi Clinical Medical Research Center of Infectious Diseases, Xi'an, Shaanxi, China. zhaoyingren@xjtu.edu.cn. AD - Clinical Research Center for Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. zhaoyingren@xjtu.edu.cn. FAU - He, Yingli AU - He Y AD - Department of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. heyingli2000@163.com. AD - Institution of Hepatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. heyingli2000@163.com. AD - Shaanxi Clinical Medical Research Center of Infectious Diseases, Xi'an, Shaanxi, China. heyingli2000@163.com. AD - Clinical Research Center for Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. heyingli2000@163.com. FAU - Yang, Yuan AU - Yang Y AUID- ORCID: 0000-0002-7033-6330 AD - Department of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. xayangyuan@mail.xjtu.edu.cn. AD - Institution of Hepatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. xayangyuan@mail.xjtu.edu.cn. AD - Shaanxi Clinical Medical Research Center of Infectious Diseases, Xi'an, Shaanxi, China. xayangyuan@mail.xjtu.edu.cn. AD - Clinical Research Center for Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. xayangyuan@mail.xjtu.edu.cn. LA - eng SI - ClinicalTrials.gov/NCT05513651 GR - No.2023M730802/China Postdoctoral Science Foundation/ PT - Journal Article PT - Multicenter Study DEP - 20250729 PL - England TA - Eur J Clin Nutr JT - European journal of clinical nutrition JID - 8804070 SB - IM MH - Humans MH - *Liver Cirrhosis/mortality/complications MH - *Nomograms MH - Male MH - Female MH - Middle Aged MH - Aged MH - Prognosis MH - *Nutrition Assessment MH - *Malnutrition/diagnosis MH - Nutritional Status COIS- Competing interests: The authors declare no competing interests. Ethical approval: The Ethics Committee of the First Affiliated Teaching Hospital School of Medicine, Xi'an Jiaotong University (XJTU1AF2020LSL-023) approved the study protocol. This study conformed to the principles of the Declaration of Helsinki. EDAT- 2025/07/30 06:30 MHDA- 2026/01/09 00:26 CRDT- 2025/07/30 00:06 PHST- 2024/03/15 00:00 [received] PHST- 2025/07/08 00:00 [accepted] PHST- 2025/06/03 00:00 [revised] PHST- 2026/01/09 00:26 [medline] PHST- 2025/07/30 06:30 [pubmed] PHST- 2025/07/30 00:06 [entrez] AID - 10.1038/s41430-025-01648-4 [pii] AID - 10.1038/s41430-025-01648-4 [doi] PST - ppublish SO - Eur J Clin Nutr. 2026 Jan;80(1):87-95. doi: 10.1038/s41430-025-01648-4. Epub 2025 Jul 29. PMID- 40729890 OWN - NLM STAT- MEDLINE DCOM- 20250910 LR - 20250910 IS - 1872-7654 (Electronic) IS - 0301-2115 (Linking) VI - 313 DP - 2025 Sep TI - Development of Z-score-based models to predict perinatal mortality in pregnancies complicated by fetal growth restriction managed at a tertiary care hospital. PG - 114612 LID - S0301-2115(25)00888-7 [pii] LID - 10.1016/j.ejogrb.2025.114612 [doi] AB - OBJECTIVE: To develop predictive models using fetal weight Z-scores to predict perinatal mortality in pregnancies affected by fetal growth restriction (FGR) in high-risk settings. STUDY DESIGN: This retrospective cohort included singleton pregnancies without congenital anomalies, delivered after 30 weeks of gestation in a tertiary hospital between 2019 and 2022. FGR was defined as weight below the 3rd percentile according to three fetal growth charts. Optimal Z-score cutoffs were identified to maximize sensitivity and specificity for perinatal mortality. Logistic regression models incorporated dichotomized Z-scores and significant predictors. Model performance was assessed using ROC curves, calibration plots, and decision curve analysis (DCA). RESULTS: Among 17 991 singleton pregnancies, 16 177 met the inclusion criteria. FGR was identified in 369 (2.3 %), 157 (1.0 %), and 335 (2.1 %) foetuses using the Hadlock, INTERGROWTH-21st (IG-21), and local customized charts, respectively. Perinatal mortality occurred in 30/369 (8.1 %), 25/157 (15.9 %), and 31/335 (9.3 %) of these groups. Z-score thresholds (-2.61, -3.17, -2.95) showed strong predictive capacity, with adjusted AUCs of 0.878, 0.884, and 0.917. The final model was logit(p) = beta(0) + beta(1)Z-score - beta(2) Gestational age - beta(3) Preeclampsia (preeclampsia excluded in IG-21). Calibration errors averaged 0.02, 0.04, and 0.02; adjusted odds ratios were 18.7, 37.6, and 23.7. The decision curve analysis suggests that integrating these models into clinical protocols may enhance perinatal risk stratification. CONCLUSION: Three Z-score-based models accurately predicted perinatal mortality in FGR-complicated pregnancies in a high-risk setting. Their integration into clinical protocols may support individualized risk stratification and decision-making. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Tipiani, Oswaldo AU - Tipiani O AD - Fetal Medicine Unit, Alberto Sabogal Sologuren National Hospital, Lima, Peru. Electronic address: oswaldo5tipi@hotmail.com. FAU - Arce, Esperanza AU - Arce E AD - Department of Obstetrics and Gynecology, Edgardo Rebagliati Martins National Hospital, Lima, Peru. LA - eng PT - Journal Article DEP - 20250725 PL - Ireland TA - Eur J Obstet Gynecol Reprod Biol JT - European journal of obstetrics, gynecology, and reproductive biology JID - 0375672 SB - IM MH - Humans MH - Female MH - *Fetal Growth Retardation/mortality MH - Pregnancy MH - Retrospective Studies MH - *Perinatal Mortality MH - Tertiary Care Centers MH - Adult MH - *Fetal Weight MH - Infant, Newborn MH - Growth Charts MH - Risk Assessment OTO - NOTNLM OT - Birth weight OT - Growth charts OT - Intrauterine growth restriction OT - Sensitivity and specificity OT - Validation study COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/07/30 00:31 MHDA- 2025/09/11 00:28 CRDT- 2025/07/29 18:07 PHST- 2024/10/29 00:00 [received] PHST- 2025/07/01 00:00 [revised] PHST- 2025/07/24 00:00 [accepted] PHST- 2025/09/11 00:28 [medline] PHST- 2025/07/30 00:31 [pubmed] PHST- 2025/07/29 18:07 [entrez] AID - S0301-2115(25)00888-7 [pii] AID - 10.1016/j.ejogrb.2025.114612 [doi] PST - ppublish SO - Eur J Obstet Gynecol Reprod Biol. 2025 Sep;313:114612. doi: 10.1016/j.ejogrb.2025.114612. Epub 2025 Jul 25. PMID- 40728055 OWN - NLM STAT- MEDLINE DCOM- 20260401 LR - 20260401 IS - 1369-1619 (Electronic) IS - 0960-3123 (Linking) VI - 36 IP - 4 DP - 2026 Apr TI - Changes in youth's physical activity: influence on screen time and cardiometabolic risk after 2-year follow-up. PG - 652-661 LID - 10.1080/09603123.2025.2538502 [doi] AB - This study aimed to verify the moderation role of changes in leisure physical activity (PA) practice in the association between screen time (ST) at baseline and cardiometabolic risk score (cMetS) at 2-year follow-up in children and adolescents. Observational longitudinal study included 333 children and adolescents (6-17 years), both sexes (girls n = 141), from public and private schools. Participants were evaluated in 2014 and 2016. The evaluation of leisure PA practice and ST behavior at baseline was applied through a self-reported questionnaire adapted from the validated questionnaire. Delta changes in leisure PA (DeltaPA) were considered. The cMetS was obtained by z-score. Association between ST at baseline and cMetS at follow-up was significantly different across different values of DeltaPA. From DeltaPA >/= 36.92 min/week, ST at baseline and cMetS at 2-year follow-up exhibited a negative relationship, indicating that even though participants presented higher amounts of ST at baseline, the cardiometabolic profile at follow-up tends to be healthy when there is a change in leisure PA from baseline to follow-up higher than this amount. The increases in leisure PA practice after a 2-year follow-up significantly moderate the negative association of ST with cardiometabolic risk factors by improving metabolic health in children and adolescents. FAU - Sehn, Ana Paula AU - Sehn AP AD - Graduate Program in Health Promotion, University of Santa Cruz do Sul (UNISC), Santa Cruz do Sul, Brazil. FAU - Brand, Caroline AU - Brand C AD - IRyS Group, Physical Education School, Pontificia Universidad Catolica de Valparaiso, Valparaiso, Chile. FAU - de Castro Silveira, Joao Francisco AU - de Castro Silveira JF AD - Graduate Program in Human Movement Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. FAU - Reuter, Eboni Marilia AU - Reuter EM AD - Graduate Program in Health Promotion, University of Santa Cruz do Sul (UNISC), Santa Cruz do Sul, Brazil. AD - Department of Health Sciences, University of Santa Cruz do Sul (UNISC), Santa Cruz do Sul, Brazil. FAU - Pollo Renner, Jane Dagmar AU - Pollo Renner JD AD - Graduate Program in Health Promotion, University of Santa Cruz do Sul (UNISC), Santa Cruz do Sul, Brazil. AD - Department of Life Sciences, University of Santa Cruz do Sul (UNISC), Santa Cruz do Sul, Brazil. FAU - Rodriguez-Rodriguez, Fernando AU - Rodriguez-Rodriguez F AD - IRyS Group, Physical Education School, Pontificia Universidad Catolica de Valparaiso, Valparaiso, Chile. FAU - Alvarez, Cristian AU - Alvarez C AD - Exercise and Rehabilitation Sciences Institute, School of Physical Therapy, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago, Chile. FAU - Reuter, Cezane Priscila AU - Reuter CP AD - Graduate Program in Health Promotion, University of Santa Cruz do Sul (UNISC), Santa Cruz do Sul, Brazil. AD - Department of Health Sciences, University of Santa Cruz do Sul (UNISC), Santa Cruz do Sul, Brazil. LA - eng PT - Journal Article PT - Observational Study DEP - 20250729 PL - England TA - Int J Environ Health Res JT - International journal of environmental health research JID - 9106628 SB - IM MH - Humans MH - Adolescent MH - Child MH - Female MH - Male MH - *Exercise MH - *Screen Time MH - Follow-Up Studies MH - Longitudinal Studies MH - Leisure Activities MH - *Cardiometabolic Risk Factors MH - Risk Factors MH - *Cardiovascular Diseases/epidemiology OTO - NOTNLM OT - Metabolic health OT - cardiovascular health OT - physical activity OT - sedentary behavior OT - youth EDAT- 2025/07/29 12:31 MHDA- 2026/04/01 07:04 CRDT- 2025/07/29 06:53 PHST- 2026/04/01 07:04 [medline] PHST- 2025/07/29 12:31 [pubmed] PHST- 2025/07/29 06:53 [entrez] AID - 10.1080/09603123.2025.2538502 [doi] PST - ppublish SO - Int J Environ Health Res. 2026 Apr;36(4):652-661. doi: 10.1080/09603123.2025.2538502. Epub 2025 Jul 29. PMID- 40725804 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250801 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 14 IP - 14 DP - 2025 Jul 18 TI - Does Continuous Injection Pressure Monitoring Reliably Detect Interfascial Planes in Regional Anesthesia? A Pilot Study of New Measurement System. LID - 10.3390/jcm14145112 [doi] LID - 5112 AB - Background/Objectives: The accurate localization of interfascial planes is critical for effective regional anesthesia, yet current techniques relying on ultrasound guidance can be challenging, especially in obese or pediatric patients. Previous cadaveric and clinical studies have suggested that injection pressure varies depending on needle placement relative to fascial and neural structures. This pilot study aimed to evaluate whether the continuous monitoring of injection pressure can reliably differentiate interfascial spaces from surrounding anatomical structures in a porcine tissue model. Methods: A custom-built pressure monitoring system was used to continuously measure saline injection pressure during regional block procedures performed on porcine thighs. Injections were guided by ultrasound and conducted using an infusion pump. Needle positions were classified as intramuscular, resting on fascia, or interfascial. Statistical comparisons of pressure levels, variability, and temporal trends were conducted using Wilcoxon signed-rank tests and regression analysis. Results: Mean intramuscular pressure was significantly higher than the mean interfascial pressure (p < 1 x 10(-13)). Interfascial injections demonstrated lower pressure variability (p = 2.1 x 10(-4)) and an increasing trend in pressure over time (p = 2.1 x 10(-4)), whereas intramuscular injections exhibited a decreasing pressure trend (p = 3.15 x 10(-3)). Conclusions: Continuous pressure monitoring effectively distinguishes interfascial from intramuscular and fascial penetration phases during regional anesthesia. The method demonstrates potential as a real-time, objective tool for enhancing needle guidance and improving the safety and accuracy of interfascial plane blocks. Further cadaveric and clinical studies are warranted to validate these findings. FAU - Wilk, Mateusz AU - Wilk M AUID- ORCID: 0000-0002-2561-7774 AD - Collegium Medicum, WSB University, 41-300 Dabrowa Gornicza, Poland. AD - Department of Anesthesiology and Intensive Care, University Clinical Center, 40-055 Katowice, Poland. FAU - Chowaniec, Malgorzata AU - Chowaniec M AD - Department of Anatomy, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-055 Katowice, Poland. FAU - Jedrasiak, Karol AU - Jedrasiak K AD - Department of Transport and Computer Science, WSB University, 41-300 Dabrowa Gornicza, Poland. FAU - Suwalska, Aleksandra AU - Suwalska A AD - Department of Data Science and Engineering, Faculty of Automatic Control, Electronics and Computer Science, Silesian University of Technology, 44-100 Gliwice, Poland. FAU - Galazka, Mariusz AU - Galazka M AD - Design Department of Environmental, Meteorological and Hydrological Measurement Devices, Technika IT Sp. Z o.o. (LL Company), 44-102 Gliwice, Poland. FAU - Wodarski, Piotr AU - Wodarski P AUID- ORCID: 0000-0001-6701-1546 AD - Department of Biomechatronics, Faculty of Biomedical Engineering, Silesian University of Technology, 44-100 Gliwice, Poland. LA - eng GR - RW/36/25/Publication financed from the project entitled "Analysis of physical factors influencing damage to nervous structures during invasive procedures in the field of regional anesthesiology and pain management" which was co-financed by the Upper Silesi-an-Dabr/ PT - Journal Article DEP - 20250718 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC12294886 OTO - NOTNLM OT - injection pressure OT - interfascial plane OT - needle OT - regional anesthesia OT - ultrasound COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2025/07/29 06:30 MHDA- 2025/07/29 06:31 PMCR- 2025/07/18 CRDT- 2025/07/29 01:17 PHST- 2025/06/10 00:00 [received] PHST- 2025/07/08 00:00 [revised] PHST- 2025/07/11 00:00 [accepted] PHST- 2025/07/29 06:31 [medline] PHST- 2025/07/29 06:30 [pubmed] PHST- 2025/07/29 01:17 [entrez] PHST- 2025/07/18 00:00 [pmc-release] AID - jcm14145112 [pii] AID - jcm-14-05112 [pii] AID - 10.3390/jcm14145112 [doi] PST - epublish SO - J Clin Med. 2025 Jul 18;14(14):5112. doi: 10.3390/jcm14145112. PMID- 40725017 OWN - NLM STAT- MEDLINE DCOM- 20250729 LR - 20250801 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 26 IP - 14 DP - 2025 Jul 15 TI - Cord Blood Exosomal miRNAs from Small-for-Gestational-Age Newborns: Association with Measures of Postnatal Catch-Up Growth and Insulin Resistance. LID - 10.3390/ijms26146770 [doi] LID - 6770 AB - Small-for-gestational-age (SGA) infants who experience a marked postnatal catch-up, mainly in weight, are at risk for developing metabolic disorders; however, the underlying mechanisms are imprecise. Exosomes and their cargo (including miRNAs) mediate intercellular communication and may contribute to altered crosstalk among tissues. We assessed the miRNA profile in cord blood-derived exosomes from 10 appropriate-for-gestational-age (AGA) and 10 SGA infants by small RNA sequencing; differentially expressed miRNAs with a fold change >/=2.4 were validated by RT-qPCR in 40 AGA and 35 SGA infants and correlated with anthropometric, body composition (DXA) and endocrine-metabolic parameters at 4 and 12 mo. miR-1-3p, miR-133a-3p and miR-206 were down-regulated, whereas miR-372-3p, miR-519d-3p and miR-1299 were up-regulated in SGA infants. The target genes of these miRNAs related to insulin, RAP1, TGF beta and neurotrophin signaling. Receiver operating characteristic analysis disclosed that these miRNAs predicted with accuracy the 0-12 mo changes in body mass index and in total and abdominal fat and lean mass. In conclusion, the exosomal miRNA profile at birth differs between AGA and SGA infants and associates with measures of catch-up growth, insulin resistance and body composition through late infancy. Further follow-up of this population will disclose whether these associations persist into childhood, puberty and adolescence. FAU - Diaz, Marta AU - Diaz M AD - Endocrinology Department, Institut de Recerca Sant Joan de Deu, University of Barcelona, 08950 Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Quesada-Lopez, Tania AU - Quesada-Lopez T AUID- ORCID: 0000-0002-7818-4351 AD - Department of Biomedicine, Institut de Recerca Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain. AD - Network Biomedical Research Center of Physiopathology of Obesity and Nutrition (CIBEROBN), Health Institute Carlos III, 28029 Madrid, Spain. FAU - Villarroya, Francesc AU - Villarroya F AD - Network Biomedical Research Center of Physiopathology of Obesity and Nutrition (CIBEROBN), Health Institute Carlos III, 28029 Madrid, Spain. AD - Biochemistry and Molecular Biomedicine Department, Institute of Biomedicine, University of Barcelona, 08950 Barcelona, Spain. AD - Institut de Recerca Sant Joan de Deu, 08950 Esplugues, Spain. FAU - Lopez-Bermejo, Abel AU - Lopez-Bermejo A AD - Pediatric Endocrinology Research Group, Girona Institute for Biomedical Research (IDIBGI), Faculty of Medicine, University of Girona and Dr. Josep Trueta Hospital, 17190 Girona, Spain. FAU - de Zegher, Francis AU - de Zegher F AD - Leuven Research & Development, University of Leuven, 3000 Leuven, Belgium. FAU - Ibanez, Lourdes AU - Ibanez L AUID- ORCID: 0000-0003-4595-7191 AD - Endocrinology Department, Institut de Recerca Sant Joan de Deu, University of Barcelona, 08950 Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Casano-Sancho, Paula AU - Casano-Sancho P AD - Endocrinology Department, Institut de Recerca Sant Joan de Deu, University of Barcelona, 08950 Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain. LA - eng GR - PI22/01424/Ministerio de Ciencia e Innovacion, Instituto de Salud Carlos III and the Fondo Europeo de Desarrollo Regional (FEDER)/ PT - Journal Article DEP - 20250715 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - 0 (MicroRNAs) SB - IM MH - Humans MH - *Infant, Small for Gestational Age/growth & development/blood MH - *Exosomes/genetics/metabolism MH - *MicroRNAs/genetics/blood MH - Infant, Newborn MH - *Insulin Resistance/genetics MH - Female MH - *Fetal Blood/metabolism MH - Male MH - Infant MH - Body Composition PMC - PMC12295645 OTO - NOTNLM OT - DXA OT - SGA OT - body composition OT - exosomes OT - insulin resistance OT - miRNAs COIS- The authors declare that no conflicts of interest exist. EDAT- 2025/07/29 06:29 MHDA- 2025/07/30 00:31 PMCR- 2025/07/15 CRDT- 2025/07/29 01:14 PHST- 2025/05/27 00:00 [received] PHST- 2025/07/06 00:00 [revised] PHST- 2025/07/09 00:00 [accepted] PHST- 2025/07/30 00:31 [medline] PHST- 2025/07/29 06:29 [pubmed] PHST- 2025/07/29 01:14 [entrez] PHST- 2025/07/15 00:00 [pmc-release] AID - ijms26146770 [pii] AID - ijms-26-06770 [pii] AID - 10.3390/ijms26146770 [doi] PST - epublish SO - Int J Mol Sci. 2025 Jul 15;26(14):6770. doi: 10.3390/ijms26146770. PMID- 40724720 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250801 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 13 IP - 14 DP - 2025 Jul 15 TI - Social Media Exposure and Muscle Dysmorphia Risk in Young German Athletes: A Cross-Sectional Survey with Machine-Learning Insights Using the MDDI-1. LID - 10.3390/healthcare13141695 [doi] LID - 1695 AB - Background and Objectives: Excessive social media use is repeatedly linked to negative body image outcomes, yet its association with muscle dysmorphia, especially in athletic youth, remains underexplored. We investigated how social media exposure, comparison behavior, and platform engagement relate to muscle dysmorphia symptomatology in young German athletes. Materials and Methods: An anonymous, web-based cross-sectional survey was conducted (July-October 2024) of 540 individuals (45% female; mean age = 24.6 +/- 5.3 years; 79% >/= 3 h sport/week) recruited via Instagram. The questionnaire comprised demographics, sport type, detailed social media usage metrics, and the validated German Muscle Dysmorphic Disorder Inventory (MDDI-1, 15 items). Correlations (Spearman's rho, Kendall's tau) were calculated; multivariate importance was probed with classification-and-regression trees and CatBoost gradient boosting, interpreted via SHAP values. Results: Median daily social media time was 76 min (IQR 55-110). Participants who spent >/= 60 min per day on social media showed higher MDDI scores (mean 38 +/- 7 vs. 35 +/- 6; p = 0.010). The strongest bivariate link emerged between perceived social media-induced body dissatisfaction and felt pressure to attain a specific body composition (Spearman rho = 0.748, Kendall tau = 0.672, p < 0.001). A CatBoost gradient-boosting model out-performed linear regression in predicting elevated MDDI. The three most influential features (via SHAP values) were daily social media time, frequency of comparison with fitness influencers, and frequency of "likes"-seeking behavior. Conclusions: Intensive social media exposure substantially heightens muscle dysmorphia risk in young German athletes. Machine-learning interpretation corroborates time on social media and influencer comparisons as primary drivers. Interventions should combine social media literacy training with sport-specific psychoeducation to mitigate maladaptive comparison cycles and prevent downstream eating disorder pathology. Longitudinal research is warranted to clarify causal pathways and to test targeted digital media interventions. FAU - Fueth, Maria AU - Fueth M AD - Department for Plastic and Hand Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Burkle-de-la-Camp Platz 1, 44789 Bochum, Germany. FAU - Schmidt, Sonja Verena AU - Schmidt SV AD - Department for Plastic and Hand Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Burkle-de-la-Camp Platz 1, 44789 Bochum, Germany. FAU - Reinkemeier, Felix AU - Reinkemeier F AD - Department for Plastic and Hand Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Burkle-de-la-Camp Platz 1, 44789 Bochum, Germany. FAU - Drysch, Marius AU - Drysch M AD - Department for Plastic and Hand Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Burkle-de-la-Camp Platz 1, 44789 Bochum, Germany. FAU - Steubing, Yonca AU - Steubing Y AD - Department for Plastic and Hand Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Burkle-de-la-Camp Platz 1, 44789 Bochum, Germany. FAU - Bausen, Simon AU - Bausen S AD - Department for Plastic and Hand Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Burkle-de-la-Camp Platz 1, 44789 Bochum, Germany. FAU - Puscz, Flemming AU - Puscz F AD - Department for Plastic and Hand Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Burkle-de-la-Camp Platz 1, 44789 Bochum, Germany. FAU - Lehnhardt, Marcus AU - Lehnhardt M AD - Department for Plastic and Hand Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Burkle-de-la-Camp Platz 1, 44789 Bochum, Germany. FAU - Wallner, Christoph AU - Wallner C AD - Department for Plastic and Hand Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Burkle-de-la-Camp Platz 1, 44789 Bochum, Germany. LA - eng PT - Journal Article DEP - 20250715 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12294503 OTO - NOTNLM OT - body image OT - body image disorder OT - body muscle dysmorphia OT - social media OT - training COIS- The authors declare that they have no conflicts of interest to disclose. EDAT- 2025/07/29 06:29 MHDA- 2025/07/29 06:30 PMCR- 2025/07/15 CRDT- 2025/07/29 01:13 PHST- 2025/05/21 00:00 [received] PHST- 2025/07/04 00:00 [revised] PHST- 2025/07/13 00:00 [accepted] PHST- 2025/07/29 06:30 [medline] PHST- 2025/07/29 06:29 [pubmed] PHST- 2025/07/29 01:13 [entrez] PHST- 2025/07/15 00:00 [pmc-release] AID - healthcare13141695 [pii] AID - healthcare-13-01695 [pii] AID - 10.3390/healthcare13141695 [doi] PST - epublish SO - Healthcare (Basel). 2025 Jul 15;13(14):1695. doi: 10.3390/healthcare13141695. PMID- 40723148 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250801 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 7 DP - 2025 Jul 20 TI - Association Between Carbohydrate Quality Index During Pregnancy and Risk for Large-for-Gestational-Age Neonates: Results from the BORN 2020 Study. LID - 10.3390/children12070955 [doi] LID - 955 AB - Background/Objectives: To assess the association between early pregnancy carbohydrate quality, as measured by the Carbohydrate Quality Index (CQI), and the risk of delivering a large-for-gestational-age (LGA) infant in a Mediterranean pregnant cohort of northern Greece. Methods: We analyzed singleton pregnancies from the BORN 2020 prospective cohort in Greece. Dietary intake was assessed via a validated food frequency questionnaire, and CQI was computed from glycemic index, fiber density, whole-to-refined grain ratio, and solid-to-liquid carbohydrate ratio. Multivariable logistic regression was used to estimate the association between CQI (in tertiles) and LGA risk, defined as birthweight >90th percentile. Results: Among the 797 participants, 152 (19.1%) delivered LGA infants, and 117 (14.7%) were diagnosed with GDM. Of those with GDM, 23 (19.7%) delivered LGA infants. In the total population, higher maternal weight (p < 0.001), height (p = 0.006), and pre-pregnancy BMI (p = 0.004) were significantly associated with LGA. A greater proportion of women with LGA had a BMI > 25 (p = 0.007). In the GDM subgroup, maternal height remained significantly higher in those who delivered LGA infants (p = 0.017). In multivariable models, moderate CQI was consistently associated with increased odds of LGA across all models (Model 1: aOR = 1.60 (95% CI: 1.03-2.50), p = 0.037, Model 2: aOR = 1.57 (95% CI: 1.01-2.46), p = 0.046, Model 3: aOR = 1.58 (95% CI: 1.01-2.47), p = 0.044, Model 4 aOR: 1.70; 95% CI: 1.08-2.72; p = 0.023), whereas high CQI was not. In the GDM subgroup, a significant association between high CQI and increased LGA risk was observed in less adjusted models (Model 1 aOR: 6.74; 95% CI: 1.32-56.66; p = 0.039, Model 2 aOR: 6.64; 95% CI: 1.27-57.48; p = 0.044), but this was attenuated and became non-significant in the fully adjusted model (aOR: 3.05; 95% CI: 0.47-30.22; p = 0.28). When examining CQI components individually, no consistent associations were observed. Notably, a higher intake of low-quality carbohydrates (>/=50% of energy intake) was significantly associated with increased LGA risk in the total population (aOR: 4.25; 95% CI: 1.53-11.67; p = 0.005). Conclusions: Higher early pregnancy intake of low-quality carbohydrates was associated with an elevated risk of LGA in the general population. However, CQI itself showed a non-linear and inconsistent relationship with LGA, with moderate, but not high, CQI linked to increased risk, particularly in GDM pregnancies, where associations were lost after adjustment. Both carbohydrate quality and quantity evaluations are essential, particularly in high-risk groups, to inform dietary guidance in pregnancy. FAU - Tranidou, Antigoni AU - Tranidou A AD - 3rd Department of Obstetrics and Gynecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece. AD - Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece. FAU - Siargkas, Antonios AU - Siargkas A AD - 3rd Department of Obstetrics and Gynecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece. AD - Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece. FAU - Tsakiridis, Ioannis AU - Tsakiridis I AUID- ORCID: 0000-0003-4337-7871 AD - 3rd Department of Obstetrics and Gynecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece. FAU - Magriplis, Emmanouela AU - Magriplis E AUID- ORCID: 0000-0001-6517-6857 AD - Department of Food Science and Human Nutrition, Agricultural University of Athens, Iera Oos 75, 118 55 Athens, Greece. FAU - Apostolopoulou, Aikaterini AU - Apostolopoulou A AUID- ORCID: 0000-0002-6391-3478 AD - Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece. FAU - Chourdakis, Michail AU - Chourdakis M AUID- ORCID: 0000-0002-9490-8356 AD - Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece. FAU - Dagklis, Themistoklis AU - Dagklis T AUID- ORCID: 0000-0002-2863-5839 AD - 3rd Department of Obstetrics and Gynecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece. LA - eng PT - Journal Article DEP - 20250720 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12293149 OTO - NOTNLM OT - CQI OT - Carbohydrate Quality Index OT - GDM OT - LGA OT - gestational diabetes mellitus OT - large for gestational age OT - nutrition OT - pregnancy COIS- The authors declare no conflicts of interest. EDAT- 2025/07/29 06:29 MHDA- 2025/07/29 06:30 PMCR- 2025/07/20 CRDT- 2025/07/29 01:07 PHST- 2025/06/09 00:00 [received] PHST- 2025/07/07 00:00 [revised] PHST- 2025/07/17 00:00 [accepted] PHST- 2025/07/29 06:30 [medline] PHST- 2025/07/29 06:29 [pubmed] PHST- 2025/07/29 01:07 [entrez] PHST- 2025/07/20 00:00 [pmc-release] AID - children12070955 [pii] AID - children-12-00955 [pii] AID - 10.3390/children12070955 [doi] PST - epublish SO - Children (Basel). 2025 Jul 20;12(7):955. doi: 10.3390/children12070955. PMID- 40723106 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250801 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 7 DP - 2025 Jul 10 TI - Validation of the Korean Pediatric Emergency Tape with Two National Anthropometric Surveys in Korean Children. LID - 10.3390/children12070913 [doi] LID - 913 AB - Background: The Korean Pediatric Emergency Tape (KPET), developed using 2005 anthropometric data, aims to improve weight estimation in Korean children. However, its validity has not been evaluated using recent large-scale data. This study evaluates the accuracy of the KPET compared with the latest version of the Broselow Tape (BT) using contemporary national anthropometric datasets. Methods: A cross-sectional analysis was conducted using pooled data from the 2019 National Health Screening Program for Infants and Children (NHSPIC, age 0-5) and the 2018-2019 Student Health Examination Sample Survey in Korea (SHESS, age 6-12). Accuracy was assessed by the proportion of estimates within 10% (PW10) and 20% (PW20) of measured weight, and by concordance between estimated and measured weight color zones. Results: Data from 1,992,646 (KPET) and 1,987,504 (BT) children were analyzed. In NHSPIC, the KPET showed slightly lower overall accuracy than the BT (PW10: 72.7% vs. 74.0%) but outperformed the BT in infants (PW10: 72.1% vs. 67.4%). In SHESS, the KPET consistently underperformed compared with the BT (PW10: 49.5% vs. 52.9%). The KPET showed higher concordance only in infants. Both tapes showed a trend of underestimation with increasing age, more pronounced in the KPET. Conclusion: The KPET showed lower overall performance than the BT but outperformed the BT in infants. Its accuracy declines in older children and tends to underestimate weight. Regular updates using recent anthropometric data are necessary to ensure accurate weight estimation and reflect current growth trends in Korean children. FAU - Suh, Dongbum AU - Suh D AUID- ORCID: 0000-0002-2449-1006 AD - Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea. AD - Department of Emergency Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea. FAU - Lee, Jin Hee AU - Lee JH AUID- ORCID: 0000-0002-2385-2834 AD - Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea. AD - Department of Emergency Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea. AD - Research Center for Disaster Medicine, Seoul National University Medical Research Center, Seoul 03080, Republic of Korea. FAU - Kwon, Hyuksool AU - Kwon H AUID- ORCID: 0000-0002-0960-0198 AD - Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea. AD - Department of Emergency Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea. LA - eng PT - Journal Article DEP - 20250710 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12293651 OTO - NOTNLM OT - child OT - critical care OT - emergencies OT - heart arrest OT - overweight OT - resuscitation OT - weights and measures COIS- The authors declare no conflicts of interest. EDAT- 2025/07/29 06:30 MHDA- 2025/07/29 06:31 PMCR- 2025/07/10 CRDT- 2025/07/29 01:06 PHST- 2025/06/11 00:00 [received] PHST- 2025/07/04 00:00 [revised] PHST- 2025/07/08 00:00 [accepted] PHST- 2025/07/29 06:31 [medline] PHST- 2025/07/29 06:30 [pubmed] PHST- 2025/07/29 01:06 [entrez] PHST- 2025/07/10 00:00 [pmc-release] AID - children12070913 [pii] AID - children-12-00913 [pii] AID - 10.3390/children12070913 [doi] PST - epublish SO - Children (Basel). 2025 Jul 10;12(7):913. doi: 10.3390/children12070913. PMID- 40723105 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250801 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 7 DP - 2025 Jul 10 TI - Mapping the Fat: How Childhood Obesity and Body Composition Shape Obstructive Sleep Apnoea. LID - 10.3390/children12070912 [doi] LID - 912 AB - Background/Objectives: Childhood obesity represents a growing public health concern. It is closely associated with obstructive sleep apnoea (OSA), which impairs nocturnal breathing and significantly affects neurocognitive and cardiovascular health. This review aims to analyse differences in fat distribution, anthropometric parameters, and instrumental assessments of paediatric OSA compared to adult OSA to improve the diagnostic characterisation of obese children. Methods: narrative review. Results: While adenotonsillar hypertrophy (ATH) remains a primary cause of paediatric OSA, the increasing prevalence of obesity has introduced distinct pathophysiological mechanisms, including fat accumulation around the pharynx, reduced respiratory muscle tone, and systemic inflammation. Children exhibit different fat distribution patterns compared to adults, with a greater proportion of subcutaneous fat relative to visceral fat. Nevertheless, cervical and abdominal adiposity are crucial in increasing upper airway collapsibility. Recent evidence highlights the predictive value of anthropometric and body composition indicators such as neck circumference (NC), neck-to-height ratio (NHR), neck-to-waist ratio (NWR), fat-to-muscle ratio (FMR), and the neck-to-abdominal-fat percentage ratio (NAF%). In addition, ultrasound assessment of lateral pharyngeal wall (LPW) thickness and abdominal fat distribution provides clinically relevant information regarding anatomical contributions to OSA severity. Among imaging modalities, dual-energy X-ray absorptiometry (DXA), bioelectrical impedance analysis (BIA), and air displacement plethysmography (ADP) have proven valuable tools for evaluating body fat distribution. Conclusions: Despite advances in the topic, a validated predictive model that integrates these parameters is still lacking in clinical practice. Polysomnography (PSG) remains the gold standard for diagnosis; however, its limited accessibility underscores the need for complementary tools to prioritise the identification of children at high risk. A multimodal approach integrating clinical, anthropometric, and imaging data could support the early identification and personalised management of paediatric OSA in obesity. FAU - Zaffanello, Marco AU - Zaffanello M AUID- ORCID: 0000-0002-8659-5505 AD - Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, 37129 Verona, Italy. FAU - Pietrobelli, Angelo AU - Pietrobelli A AUID- ORCID: 0000-0002-9912-3232 AD - Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, 37129 Verona, Italy. FAU - Piacentini, Giorgio AU - Piacentini G AD - Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, 37129 Verona, Italy. FAU - Zoller, Thomas AU - Zoller T AD - Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, 37129 Verona, Italy. FAU - Nosetti, Luana AU - Nosetti L AUID- ORCID: 0000-0001-5453-724X AD - Department of Medicine and Technological Innovation, Insubria University, F del Ponte Hospital, 21100 Varese, Italy. FAU - Guzzo, Alessandra AU - Guzzo A AD - Laboratory Unit, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37129 Verona, Italy. FAU - Antoniazzi, Franco AU - Antoniazzi F AUID- ORCID: 0000-0003-1405-1792 AD - Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, 37129 Verona, Italy. LA - eng PT - Journal Article PT - Review DEP - 20250710 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12293431 OTO - NOTNLM OT - anthropometric measure OT - body composition OT - children OT - fat distribution OT - obesity OT - obstructive sleep apnoea OT - polysomnography OT - sleep disordered breathing OT - ultrasonography COIS- The authors declare no conflicts of interest. EDAT- 2025/07/29 06:30 MHDA- 2025/07/29 06:31 PMCR- 2025/07/10 CRDT- 2025/07/29 01:06 PHST- 2025/05/27 00:00 [received] PHST- 2025/07/02 00:00 [revised] PHST- 2025/07/08 00:00 [accepted] PHST- 2025/07/29 06:31 [medline] PHST- 2025/07/29 06:30 [pubmed] PHST- 2025/07/29 01:06 [entrez] PHST- 2025/07/10 00:00 [pmc-release] AID - children12070912 [pii] AID - children-12-00912 [pii] AID - 10.3390/children12070912 [doi] PST - epublish SO - Children (Basel). 2025 Jul 10;12(7):912. doi: 10.3390/children12070912. PMID- 40723039 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250801 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 7 DP - 2025 Jun 27 TI - Active Minds, Healthy Bodies: Investigating Physical Activity, Barriers, and Health Outcomes in Saudi Adolescent Females. LID - 10.3390/children12070846 [doi] LID - 846 AB - Background: Physical inactivity among adolescents, particularly females in conservative societies like Saudi Arabia, poses significant risks to both physical and psychological health. Cultural norms, environmental constraints, and limited access to gender-appropriate sports facilities further exacerbate the problem. Understanding these factors is essential for developing effective, context-sensitive interventions. Aim: This study aimed to examine the relationship between daily physical activity behaviours and health outcomes, both physical and psychological, among adolescent females in Saudi Arabia. This paper also explores the impact of socio-environmental variables such as income, household size, and urban/rural residence on activity levels and wellbeing. Methods: A cross-sectional survey of 636 adolescent females aged 13-21 was conducted using validated instruments. The Physical Activity Questionnaire for Adolescents (PAQ-A) measured physical activity levels, and the Self-Rated Health (SRH) assessed psychological wellbeing and health-related quality of life. The analysis employed an Ordinal Logistic Model (OLM) guided by the Social Ecological Model (SEM) to assess predictors of physical activity participation. Results: The OLM results indicated that higher income levels, smaller household size, urban residence, and older age categories were significantly associated with higher levels of physical activity (p < 0.05). Participants with higher PAQ-A scores reported better psychological health and quality of life. The model showed a good fit, with a pseudo-R(2) of 0.36. Cultural and environmental barriers, particularly in rural areas, were identified as significant deterrents to participation. Conclusions: The findings highlight the urgent need for culturally adapted, gender-sensitive health promotion programs that target both individual and structural barriers to physical activity among adolescent girls in Saudi Arabia. Enhanced societal support and accessible sports infrastructure could significantly improve health outcomes and quality of life. FAU - Saleh, Wafaa AU - Saleh W AD - Transport Research Institute, School of Computing, Engineering and the Built Environment, Edinburgh Napier University, Edinburgh EH10 5DT, UK. FAU - Alturif, Ghada AU - Alturif G AD - Department of Social Work, College of Humanities and Social Sciences, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. LA - eng GR - RI-44-0248/princess nourah/ PT - Journal Article DEP - 20250627 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12293993 OTO - NOTNLM OT - Ordinal Logistic Model (OLM) OT - PAQ-A OT - SEM OT - Saudi Arabia OT - Self-Rated Health (SRH) OT - adolescents OT - environmental barriers OT - physical activity COIS- The authors declare no conflict of interest. EDAT- 2025/07/29 06:30 MHDA- 2025/07/29 06:31 PMCR- 2025/06/27 CRDT- 2025/07/29 01:06 PHST- 2025/05/25 00:00 [received] PHST- 2025/06/13 00:00 [revised] PHST- 2025/06/25 00:00 [accepted] PHST- 2025/07/29 06:31 [medline] PHST- 2025/07/29 06:30 [pubmed] PHST- 2025/07/29 01:06 [entrez] PHST- 2025/06/27 00:00 [pmc-release] AID - children12070846 [pii] AID - children-12-00846 [pii] AID - 10.3390/children12070846 [doi] PST - epublish SO - Children (Basel). 2025 Jun 27;12(7):846. doi: 10.3390/children12070846. PMID- 40723037 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250801 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 7 DP - 2025 Jun 26 TI - Adherence to the Mediterranean Diet and Arterial Blood Pressure in Schoolchildren: The Role of Parental Eating Habits. LID - 10.3390/children12070844 [doi] LID - 844 AB - Background/Objectives: The aim of the present study was to examine the association between the systolic (SBP) as well as diastolic blood pressure (DBP) levels of school-aged children and the adherence of both children and their parents to the Mediterranean Diet. Methods: Detailed data on sociodemographic characteristics, eating habits, and anthropometry were collected from each child (N = 102) and their accompanied parent or legal guardian (N = 102). KIDMED (range: -4 to 12) was used to evaluate children's level of adherence to the Mediterranean Diet and MedDietScore (range: 0-55) was used for parents. Children's blood pressure (BP) was measured using a validated automated oscillometric device. Results: Children with higher adherence to the Mediterranean Diet had significantly lower SBP (p < 0.001), DBP (p = 0.009), and hip circumference (p = 0.01) compared to those with lower adherence. Similarly, children of parents with high adherence to the Mediterranean Diet exhibited lower body weight (p = 0.03), waist circumference (p = 0.03), SBP (p < 0.001), and DBP (p = 0.004). In fully adjusted models, for each unit increase in children's KIDMED scores, a 1.33 unit reduction in SBP (p < 0.001), and a 0.77 unit reduction in DBP were found. Similarly, parental MedDietScore was independently associated with significant reductions in children's SBP (1.01 mmHg) and DBP (0.75 mmHg) (all p's < 0.05). Conclusions: Adherence to the Mediterranean dietary pattern by children and parents seems to be associated with lower BP in childhood, supporting the potential value of a family-based approach, particularly involving mothers. FAU - Foscolou, Alexandra AU - Foscolou A AUID- ORCID: 0000-0002-8068-577X AD - Department of Nutritional Science and Dietetics, School of Health Sciences, University of the Peloponnese, Antikalamos, 24100 Kalamata, Greece. FAU - Papandreou, Panos AU - Papandreou P AD - Department of Nutrition, IASO Hospital, 37-39 Kifissias Ave., 15123 Athens, Greece. FAU - Bikaki, Aikaterini AU - Bikaki A AD - Department of Nutrition & Dietetics, School of Health Sciences and Education, Harokopio University, 70 El. Venizelou Ave., 17676 Athens, Greece. FAU - Skouroliakou, Maria AU - Skouroliakou M AUID- ORCID: 0000-0002-0468-8397 AD - Department of Nutrition & Dietetics, School of Health Sciences and Education, Harokopio University, 70 El. Venizelou Ave., 17676 Athens, Greece. FAU - Gioxari, Aristea AU - Gioxari A AUID- ORCID: 0000-0002-4869-6815 AD - Department of Nutritional Science and Dietetics, School of Health Sciences, University of the Peloponnese, Antikalamos, 24100 Kalamata, Greece. LA - eng PT - Journal Article DEP - 20250626 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12293527 OTO - NOTNLM OT - Mediterranean Diet OT - children OT - diastolic blood pressure OT - parents OT - systolic blood pressure COIS- The authors declare no conflicts of interest. EDAT- 2025/07/29 06:29 MHDA- 2025/07/29 06:30 PMCR- 2025/06/26 CRDT- 2025/07/29 01:06 PHST- 2025/05/23 00:00 [received] PHST- 2025/06/20 00:00 [revised] PHST- 2025/06/25 00:00 [accepted] PHST- 2025/07/29 06:30 [medline] PHST- 2025/07/29 06:29 [pubmed] PHST- 2025/07/29 01:06 [entrez] PHST- 2025/06/26 00:00 [pmc-release] AID - children12070844 [pii] AID - children-12-00844 [pii] AID - 10.3390/children12070844 [doi] PST - epublish SO - Children (Basel). 2025 Jun 26;12(7):844. doi: 10.3390/children12070844. PMID- 40723007 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250801 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 7 DP - 2025 Jun 21 TI - Feeding with Care: Caregiver Perspectives on Pediatric Gastrostomy Tubes. LID - 10.3390/children12070813 [doi] LID - 813 AB - Background/Objectives: Gastrostomy tube (GT) placement plays a vital role in managing children with chronic illnesses who are unable to meet their nutritional needs orally. While its clinical benefits are well established, limited data exist on caregivers' satisfaction with GT use in Jordan. This study aimed to assess caregivers' satisfaction and identify factors that influence their experiences by using a validated satisfaction scoring system in which a score greater than 20 indicates a high level of satisfaction. Methods: A cross-sectional study was conducted at Jordan University Hospital, including children under 18 years of age who underwent endoscopic GT insertion between July 2017 and December 2024. Caregivers completed the Structured Satisfaction Questionnaire with Gastrostomy Feeding (SAGA-8), and demographic and clinical data were collected. Statistical analyses explored associations between satisfaction levels and patient-, caregiver-, and healthcare-related factors. Results: A total of 46 caregivers participated. The median satisfaction score was 26.1, surpassing the high satisfaction threshold of 20. Overall, 63% of caregivers expressed satisfaction or high satisfaction with GT feeding, and 82.6% were satisfied with the support provided by the healthcare team. Additionally, 69.5% and 65.2% of caregivers reported improvements in their child's nutritional status and overall family well-being, respectively. Notably, 89.1% observed a reduction in feeding time, and 84.8% reported fewer respiratory infections following GT placement. Over half of the caregivers (58.7%) indicated that they would have agreed to earlier GT placement if they had been more aware of its benefits. Conclusions: Caregivers reported high satisfaction with GT use, with scores well above the validated threshold indicating high satisfaction. These findings highlight the positive impact of GT placement on children's health outcomes and family quality of life. Enhancing caregiver education and providing robust healthcare support are crucial to improving the management of children who require GT feeding. FAU - Khdair Ahmad, Fareed AU - Khdair Ahmad F AUID- ORCID: 0000-0002-6359-6601 AD - Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, School of Medicine, The University of Jordan, Amman 11942, Jordan. AD - Jordan University Hospital, Amman 11942, Jordan. AD - School of Medicine, The University of Jordan, Amman 11942, Jordan. AD - Gastroenterology Interest Group (GIG), School of Medicine, The University of Jordan, Amman 11942, Jordan. FAU - Al-Assaf, Noor F AU - Al-Assaf NF AUID- ORCID: 0009-0003-7391-5092 AD - School of Medicine, The University of Jordan, Amman 11942, Jordan. AD - Gastroenterology Interest Group (GIG), School of Medicine, The University of Jordan, Amman 11942, Jordan. FAU - Alzoubi, Mohammad AU - Alzoubi M AD - School of Medicine, The University of Jordan, Amman 11942, Jordan. AD - Gastroenterology Interest Group (GIG), School of Medicine, The University of Jordan, Amman 11942, Jordan. FAU - Odeh, Nada AU - Odeh N AUID- ORCID: 0009-0009-2422-4061 AD - School of Medicine, The University of Jordan, Amman 11942, Jordan. AD - Gastroenterology Interest Group (GIG), School of Medicine, The University of Jordan, Amman 11942, Jordan. FAU - Samara, Dina AU - Samara D AUID- ORCID: 0009-0007-8062-4495 AD - School of Medicine, The University of Jordan, Amman 11942, Jordan. FAU - Samara, Zaid Arafat AU - Samara ZA AD - School of Medicine, The University of Jordan, Amman 11942, Jordan. FAU - AlHammouri, Hashim M AU - AlHammouri HM AUID- ORCID: 0009-0003-6314-2620 AD - School of Medicine, The University of Jordan, Amman 11942, Jordan. AD - Gastroenterology Interest Group (GIG), School of Medicine, The University of Jordan, Amman 11942, Jordan. FAU - Ahmad, Tahani AU - Ahmad T AUID- ORCID: 0000-0001-9885-6090 AD - Jordan University Hospital, Amman 11942, Jordan. AD - School of Medicine, The University of Jordan, Amman 11942, Jordan. AD - Department of Radiology and Nuclear Medicine, School of Medicine, The University of Jordan, Amman 11942, Jordan. FAU - Burayzat, Salma AU - Burayzat S AUID- ORCID: 0000-0001-7265-5055 AD - Department of Pediatrics and Neonatology, Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan. FAU - Alqudah, Omar AU - Alqudah O AUID- ORCID: 0009-0002-8491-1655 AD - Jordan University Hospital, Amman 11942, Jordan. AD - School of Medicine, The University of Jordan, Amman 11942, Jordan. AD - Gastroenterology Interest Group (GIG), School of Medicine, The University of Jordan, Amman 11942, Jordan. AD - Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, The University of Jordan, Amman 11942, Jordan. FAU - Khamees, Nadia AU - Khamees N AUID- ORCID: 0009-0001-8776-637X AD - Jordan University Hospital, Amman 11942, Jordan. AD - School of Medicine, The University of Jordan, Amman 11942, Jordan. AD - Gastroenterology Interest Group (GIG), School of Medicine, The University of Jordan, Amman 11942, Jordan. AD - Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, The University of Jordan, Amman 11942, Jordan. FAU - Tamimi, Tarek A AU - Tamimi TA AD - Jordan University Hospital, Amman 11942, Jordan. AD - School of Medicine, The University of Jordan, Amman 11942, Jordan. AD - Gastroenterology Interest Group (GIG), School of Medicine, The University of Jordan, Amman 11942, Jordan. AD - Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, The University of Jordan, Amman 11942, Jordan. FAU - Abu Sneineh, Awni AU - Abu Sneineh A AUID- ORCID: 0000-0003-4621-3805 AD - Jordan University Hospital, Amman 11942, Jordan. AD - School of Medicine, The University of Jordan, Amman 11942, Jordan. AD - Gastroenterology Interest Group (GIG), School of Medicine, The University of Jordan, Amman 11942, Jordan. AD - Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, The University of Jordan, Amman 11942, Jordan. FAU - Rayyan, Yaser AU - Rayyan Y AUID- ORCID: 0000-0002-0421-5143 AD - Jordan University Hospital, Amman 11942, Jordan. AD - School of Medicine, The University of Jordan, Amman 11942, Jordan. AD - Gastroenterology Interest Group (GIG), School of Medicine, The University of Jordan, Amman 11942, Jordan. AD - Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, The University of Jordan, Amman 11942, Jordan. LA - eng PT - Journal Article DEP - 20250621 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12294023 OTO - NOTNLM OT - Jordan OT - SAGA-8 questionnaire OT - caregiver satisfaction OT - gastrostomy tube OT - home enteral nutrition OT - pediatric nutrition OT - percutaneous endoscopic gastrostomy PEG OT - quality of life COIS- The authors declare no conflicts of interest. EDAT- 2025/07/29 06:30 MHDA- 2025/07/29 06:31 PMCR- 2025/06/21 CRDT- 2025/07/29 01:06 PHST- 2025/05/17 00:00 [received] PHST- 2025/06/14 00:00 [revised] PHST- 2025/06/19 00:00 [accepted] PHST- 2025/07/29 06:31 [medline] PHST- 2025/07/29 06:30 [pubmed] PHST- 2025/07/29 01:06 [entrez] PHST- 2025/06/21 00:00 [pmc-release] AID - children12070813 [pii] AID - children-12-00813 [pii] AID - 10.3390/children12070813 [doi] PST - epublish SO - Children (Basel). 2025 Jun 21;12(7):813. doi: 10.3390/children12070813. PMID- 40722021 OWN - NLM STAT- MEDLINE DCOM- 20250729 LR - 20250731 IS - 1477-7525 (Electronic) IS - 1477-7525 (Linking) VI - 23 IP - 1 DP - 2025 Jul 28 TI - Associations between 24-hour movement guidelines and health-related quality of life among urban preschool children in Singapore, Japan, and China. PG - 75 LID - 10.1186/s12955-025-02408-5 [doi] LID - 75 AB - BACKGROUND: Health-related quality of life (HRQoL) is increasingly recognized as a critical indicator of well-being in early childhood, yet its associations with 24-hour movement behaviors-physical activity, screen time, and sleep-remain underexplored in Asian populations. This study aims to examine the association between adherence to the 24-hour movement guidelines (24-MG) and health-related quality of life (HRQOL) among preschoolers residing in major urban areas of Singapore, Japan, and China. METHODS: A cross-sectional survey was conducted among 6,634 children aged 3-6 years across Singapore (n = 3,672), Japan (n = 760), and China (n = 2,202). Movement behaviors were assessed using the validated SMALLQ((R)) tool, and HRQoL was evaluated using the Pediatric Quality of Life Inventory (PedsQL). Logistic regression models were applied to determine the associations between different patterns of 24-h MG adherence and HRQoL, adjusting for demographic variables. RESULTS: Full adherence to all three 24-h MG components was significantly associated with higher physical and psychosocial HRQoL scores in Singapore and China. In Japan, adherence to physical activity guidelines alone is associated with higher HRQoL. Notably, Chinese children had the highest adherence rates across all individual and combined movement behaviors. Conversely, Japanese children had the lowest rates of full adherence and were more likely to fall short of all guidelines. CONCLUSIONS: This study provides novel evidence from three urban Asian contexts that adherence to the 24-hour movement guidelines positively correlates with HRQoL in preschool-aged children. The findings highlight the importance of integrated movement behavior frameworks and support the development of culturally tailored public health policies to improve early childhood well-being. CI - (c) 2025. The Author(s). FAU - Chung, Ho Jin AU - Chung HJ AD - National Institute of Education, Nanyang Technological University, Singapore, 637616, Singapore. FAU - Kim, Hyunshik AU - Kim H AD - National Institute of Education, Nanyang Technological University, Singapore, 637616, Singapore. AD - Faculty of Sports Education, Sendai University, 2-2-18 Funaokaminami, Shibata-machi, Miyagi-ken, 9891693, Japan. FAU - Ma, Jiameng AU - Ma J AD - National Institute of Education, Nanyang Technological University, Singapore, 637616, Singapore. AD - Faculty of Sports Education, Sendai University, 2-2-18 Funaokaminami, Shibata-machi, Miyagi-ken, 9891693, Japan. FAU - Chua, Terence AU - Chua T AD - National Institute of Education, Nanyang Technological University, Singapore, 637616, Singapore. FAU - Low, Seow Ting AU - Low ST AD - National Institute of Education, Nanyang Technological University, Singapore, 637616, Singapore. FAU - Li, Dan AU - Li D AD - National Institute of Education, Nanyang Technological University, Singapore, 637616, Singapore. FAU - Guo, Hongzhi AU - Guo H AD - Graduate School of Human Sciences, Waseda University, Tokorozawa, Saitama, 3591192, Japan. FAU - Chia, Michael Yong Hwa AU - Chia MYH AD - National Institute of Education, Nanyang Technological University, Singapore, 637616, Singapore. michael.chia@nie.edu.sg. LA - eng GR - OER 29/19 MCYH/Singapore Ministry of Education (MOE)/ PT - Journal Article DEP - 20250728 PL - England TA - Health Qual Life Outcomes JT - Health and quality of life outcomes JID - 101153626 SB - IM MH - Humans MH - *Quality of Life/psychology MH - Male MH - Female MH - Singapore MH - Child, Preschool MH - Cross-Sectional Studies MH - China MH - Child MH - *Exercise/psychology MH - Japan MH - *Urban Population/statistics & numerical data MH - Screen Time MH - Surveys and Questionnaires MH - Guidelines as Topic MH - Sleep PMC - PMC12306139 OTO - NOTNLM OT - 24-hour movement guidelines OT - Asia OT - Health-related quality of life OT - Physical activity OT - Preschool children OT - Screen time OT - Sleep duration OT - Urban health COIS- Declarations. Human ethics and consent to participate and publish: All participating researchers adhered to the ethical standards outlined in the Declaration of Helsinki. The study protocols were approved by the institutional ethics committees in each respective country (Singapore: IRB2019-02-036; Japan: SU2019-31; China: HR 405 - 202). Considering the involvement of minor participants, informed consent for participation and publication of anonymized data was obtained from their parents and/or legal guardians prior to participation. Consent to publish: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/07/29 06:29 MHDA- 2025/07/29 18:31 PMCR- 2025/07/28 CRDT- 2025/07/29 00:15 PHST- 2025/04/24 00:00 [received] PHST- 2025/07/17 00:00 [accepted] PHST- 2025/07/29 18:31 [medline] PHST- 2025/07/29 06:29 [pubmed] PHST- 2025/07/29 00:15 [entrez] PHST- 2025/07/28 00:00 [pmc-release] AID - 10.1186/s12955-025-02408-5 [pii] AID - 2408 [pii] AID - 10.1186/s12955-025-02408-5 [doi] PST - epublish SO - Health Qual Life Outcomes. 2025 Jul 28;23(1):75. doi: 10.1186/s12955-025-02408-5. PMID- 40721519 OWN - NLM STAT- MEDLINE DCOM- 20250729 LR - 20250802 IS - 2041-1723 (Electronic) IS - 2041-1723 (Linking) VI - 16 IP - 1 DP - 2025 Jul 28 TI - Causal mediation analysis for time-varying heritable risk factors with Mendelian randomization. PG - 6945 LID - 10.1038/s41467-025-61648-7 [doi] LID - 6945 AB - Understanding the causal mechanisms of diseases is crucial in clinical research. When randomized experiments are unavailable, Mendelian Randomization (MR) leverages genetic mutations to mitigate confounding. However, most MR analyses assume static risk factors, oversimplifying dynamic risk factor effects. The framework of life-course MR addresses this but struggles with limited GWAS cohort sizes and correlations across time points. We propose FLOW-MR, a computational approach estimating causal structural equations for temporally ordered traits using only GWAS summary statistics. FLOW-MR enables inference on direct, indirect, and path-wise causal effects, demonstrating superior efficiency and reliability, especially with noisy data. By incorporating a spike-and-slab prior, it mitigates challenges from extreme polygenicity and weak instruments. Applying FLOW-MR, we uncovered a childhood-specific protective effect of BMI on breast cancer and analyzed the evolving impacts of BMI, systolic blood pressure, and cholesterol on stroke risk, revealing their causal relationships. CI - (c) 2025. The Author(s). FAU - Wu, Zixuan AU - Wu Z AUID- ORCID: 0009-0006-4745-0000 AD - Department of Statistics, University of Chicago, Chicago, IL, USA. FAU - Lewis, Ethan AU - Lewis E AUID- ORCID: 0009-0001-4955-2506 AD - Department of Statistics, University of Chicago, Chicago, IL, USA. FAU - Zhao, Qingyuan AU - Zhao Q AUID- ORCID: 0000-0001-9902-2768 AD - Statistical Laboratory, Department of Pure Mathematics and Mathematical Statistics, University of Cambridge, Cambridge, UK. FAU - Wang, Jingshu AU - Wang J AUID- ORCID: 0000-0002-1968-6888 AD - Department of Statistics, University of Chicago, Chicago, IL, USA. jingshuw@uchicago.edu. LA - eng GR - DMS-2113646/National Science Foundation (NSF)/ GR - DMS-2238656/National Science Foundation (NSF)/ GR - EP/V049968/1/RCUK | Engineering and Physical Sciences Research Council (EPSRC)/ PT - Journal Article DEP - 20250728 PL - England TA - Nat Commun JT - Nature communications JID - 101528555 RN - 97C5T2UQ7J (Cholesterol) SB - IM MH - *Mendelian Randomization Analysis/methods MH - Humans MH - Risk Factors MH - Genome-Wide Association Study MH - Female MH - Body Mass Index MH - Breast Neoplasms/genetics/epidemiology MH - Blood Pressure/genetics MH - Causality MH - *Mediation Analysis MH - Stroke/genetics/epidemiology MH - Genetic Predisposition to Disease MH - Cholesterol/blood MH - Polymorphism, Single Nucleotide PMC - PMC12304142 COIS- Competing interests: The authors declare no competing interests. EDAT- 2025/07/29 00:57 MHDA- 2025/07/30 05:10 PMCR- 2025/07/28 CRDT- 2025/07/28 23:20 PHST- 2024/08/20 00:00 [received] PHST- 2025/06/24 00:00 [accepted] PHST- 2025/07/30 05:10 [medline] PHST- 2025/07/29 00:57 [pubmed] PHST- 2025/07/28 23:20 [entrez] PHST- 2025/07/28 00:00 [pmc-release] AID - 10.1038/s41467-025-61648-7 [pii] AID - 61648 [pii] AID - 10.1038/s41467-025-61648-7 [doi] PST - epublish SO - Nat Commun. 2025 Jul 28;16(1):6945. doi: 10.1038/s41467-025-61648-7. PMID- 40721459 OWN - NLM STAT- MEDLINE DCOM- 20250729 LR - 20250801 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Jul 28 TI - 3D anthropometry of the nasolabial region in children aged 3 to 9 months as reference database for clinical assessment. PG - 27443 LID - 10.1038/s41598-025-11024-8 [doi] LID - 27443 AB - Treatment for a cleft lip can result in significant functional and aesthetic changes to the nasolabial region. Although three-dimensional (3D) measurements are the gold standard for evaluating cleft surgery, most short- and long-term evaluations still rely on subjective assessment or the measurement of patient photographs. To our knowledge, this work establishes the first baseline and reference group for the nasolabial region in children aged 3 to 9 months without cleft lip or palate. This group can be used for future evaluations, such as those of surgical outcomes or NAM therapy, via 3D anthropometric measurement. Data was collected cross-sectionally from 25 children aged 3 to 9 months using a validated intraoral scanner (Trios 4, 3Shape). Scans were analysed according to 3D anthropometric criteria by metrically accurate measurements of distances, surface curves and angles using 3D inspection software (GOM Inspect, Co. Zeiss, Jena, Germany). Results are presented as reference database combined with a step-by-step guide on the measurement methodology. For easy application all data are additionally presented in the form of formulae in which clinical data can be inserted. Based on the data from healthy children, we propose a new classification of alar base types ranging from 1 to 3. Unlike conventional assessment methods, surface curves and other 3D anthropometric tools provide a highly accurate and objective quantification of the anatomy of the nasolabial region and thus serve as a foundation for future clinical research on cleft lip surgery. Alar base type classification may influence future surgical approaches to cleft lip surgery. CI - (c) 2025. The Author(s). FAU - Olmos, Manuel AU - Olmos M AD - Department of Oral and Cranio-Maxillofacial Surgery, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Glueckstrasse 11, 91054, Erlangen, Germany. AD - Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), Erlangen, Germany. FAU - Backhaus, Joy AU - Backhaus J AD - Institute of Medical Teaching and Medical Education Research, University Hospital of Wurzburg, Wurzburg, Germany. FAU - Weber, Manuel AU - Weber M AD - Department of Oral and Cranio-Maxillofacial Surgery, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Glueckstrasse 11, 91054, Erlangen, Germany. FAU - Matta, Ragai AU - Matta R AD - Department of Prosthodontics, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Germany. FAU - Vogl, Christoph AU - Vogl C AD - Department of Oral and Cranio-Maxillofacial Surgery, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Glueckstrasse 11, 91054, Erlangen, Germany. FAU - Schulz, Katja AU - Schulz K AD - Department of Oral and Cranio-Maxillofacial Surgery, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Glueckstrasse 11, 91054, Erlangen, Germany. FAU - Beyer, Sandra AU - Beyer S AD - Department of Oral and Cranio-Maxillofacial Surgery, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Glueckstrasse 11, 91054, Erlangen, Germany. FAU - Winter, Linus AU - Winter L AD - Department of Oral and Cranio-Maxillofacial Surgery, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Glueckstrasse 11, 91054, Erlangen, Germany. FAU - Schutzenberger, Anne AU - Schutzenberger A AD - Division of Phoniatrics and Pediatric Audiology, Department of Otorhinolaryngology Head & Neck Surgery, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen University Hospital, Erlangen, Germany. FAU - Kesting, Marco AU - Kesting M AD - Department of Oral and Cranio-Maxillofacial Surgery, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Glueckstrasse 11, 91054, Erlangen, Germany. FAU - Lutz, Rainer AU - Lutz R AD - Department of Oral and Cranio-Maxillofacial Surgery, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Glueckstrasse 11, 91054, Erlangen, Germany. rainer.lutz@uk-erlangen.de. LA - eng PT - Journal Article DEP - 20250728 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Male MH - Infant MH - *Imaging, Three-Dimensional/methods MH - *Anthropometry/methods MH - *Cleft Lip/surgery/diagnostic imaging MH - *Nose/anatomy & histology/diagnostic imaging MH - *Lip/anatomy & histology/diagnostic imaging MH - Cross-Sectional Studies MH - Databases, Factual MH - Cleft Palate/surgery PMC - PMC12304160 OTO - NOTNLM OT - 3D OT - Alar base types OT - Anthropometry OT - Assessment OT - Cleft surgery OT - Evaluation OT - Reference COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: The study was approved by the Ethics Committee of the Friedrich-Alexander University of Erlangen-Nurnberg on May 6, 2022 under the application number 22-100-B. EDAT- 2025/07/29 00:58 MHDA- 2025/07/30 05:11 PMCR- 2025/07/28 CRDT- 2025/07/28 23:17 PHST- 2025/05/29 00:00 [received] PHST- 2025/07/07 00:00 [accepted] PHST- 2025/07/30 05:11 [medline] PHST- 2025/07/29 00:58 [pubmed] PHST- 2025/07/28 23:17 [entrez] PHST- 2025/07/28 00:00 [pmc-release] AID - 10.1038/s41598-025-11024-8 [pii] AID - 11024 [pii] AID - 10.1038/s41598-025-11024-8 [doi] PST - epublish SO - Sci Rep. 2025 Jul 28;15(1):27443. doi: 10.1038/s41598-025-11024-8. PMID- 40721146 OWN - NLM STAT- MEDLINE DCOM- 20251024 LR - 20260923 IS - 1873-2607 (Electronic) IS - 0749-3797 (Linking) VI - 69 IP - 5 DP - 2025 Nov TI - Prenatal Substance Exposure and Obesity: Trajectories of Tri-Ponderal Mass Index in Early Adolescence. PG - 107997 LID - S0749-3797(25)00488-X [pii] LID - 10.1016/j.amepre.2025.107997 [doi] AB - INTRODUCTION: The long-term impact of prenatal substance exposure on obesity remains inconclusive. Few studies have explored the trajectories of tri-ponderal mass index, despite its greater accuracy and reliability in assessing adolescent adiposity. The aim of this study was to examine adiposity trajectories assessed by tri-ponderal mass index from preadolescence age to early adolescence and the influence of prenatal substance exposure on these patterns. METHODS: This study used data from the Adolescent Brain Cognitive Development study (Release 5.1), an ongoing longitudinal study on child development. Data were collected between 2016 and 2021. A total of 7,881 children with data across 5 waves were included. Prenatal substance exposure (tobacco, alcohol, caffeine, marijuana) was reported by mothers. Latent growth mixture modeling was conducted to identify tri-ponderal mass index trajectories, followed by multinomial logistic regression to examine the role of prenatal substance exposure, controlling for covariates. All analyses were conducted in 2024. RESULTS: Three trajectories emerged: stable tri-ponderal mass index (86.6%), increasing tri-ponderal mass index (12.5%), and decreasing tri-ponderal mass index (0.9%). The risk of increasing tri-ponderal mass index was associated with prenatal tobacco and caffeine exposure, showing dose-dependent effects. Tobacco exposure both before and after awareness of pregnancy increased the risk, with no significant benefit from cessation. Prenatal exposure to multiple substances further elevated the risk of increasing tri-ponderal mass index. CONCLUSIONS: Obesity risk can originate prenatally. The long-term impact of prenatal substance exposure on adiposity development during adolescence highlights the need for preconception and prenatal health interventions to reduce obesity risk in offspring. CI - Copyright (c) 2025 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Li, Ru AU - Li R AD - Department of Psychiatry, Turku University Hospital, University of Turku, Turku, Finland; Clinical Neurosciences, University of Turku, Turku, Finland; Neurocenter, Turku University Hospital, Turku, Finland; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, Turku University Hospital, University of Turku, Turku, Finland; Sleep & Circadian Psychology Research Unit, Department of Psychology and Behavioral Sciences, Aarhus University, Aarhus, Denmark. Electronic address: ru.li@utu.fi. FAU - Wigley, Isabella Mariani AU - Wigley IM AD - Department of Psychiatry, Turku University Hospital, University of Turku, Turku, Finland; Clinical Neurosciences, University of Turku, Turku, Finland; Neurocenter, Turku University Hospital, Turku, Finland; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, Turku University Hospital, University of Turku, Turku, Finland. FAU - Suuronen, Ilkka AU - Suuronen I AD - Department of Psychiatry, Turku University Hospital, University of Turku, Turku, Finland; Clinical Neurosciences, University of Turku, Turku, Finland; Neurocenter, Turku University Hospital, Turku, Finland; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, Turku University Hospital, University of Turku, Turku, Finland. FAU - Jolly, Ashmeet AU - Jolly A AD - Department of Psychiatry, Turku University Hospital, University of Turku, Turku, Finland; Clinical Neurosciences, University of Turku, Turku, Finland; Neurocenter, Turku University Hospital, Turku, Finland; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, Turku University Hospital, University of Turku, Turku, Finland; Department of Psychology and Speech Language Pathology, University of Turku, Turku, Finland; Department of Teacher Education, University of Turku, Turku, Finland. FAU - Tuulari, Jetro J AU - Tuulari JJ AD - Department of Psychiatry, Turku University Hospital, University of Turku, Turku, Finland; Clinical Neurosciences, University of Turku, Turku, Finland; Neurocenter, Turku University Hospital, Turku, Finland; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, Turku University Hospital, University of Turku, Turku, Finland. LA - eng GR - U01 DA041022/DA/NIDA NIH HHS/United States GR - U01 DA041025/DA/NIDA NIH HHS/United States GR - U01 DA041028/DA/NIDA NIH HHS/United States GR - U01 DA041048/DA/NIDA NIH HHS/United States GR - U01 DA041089/DA/NIDA NIH HHS/United States GR - U01 DA041093/DA/NIDA NIH HHS/United States GR - U01 DA041106/DA/NIDA NIH HHS/United States GR - U01 DA041117/DA/NIDA NIH HHS/United States GR - U01 DA041120/DA/NIDA NIH HHS/United States GR - U01 DA041134/DA/NIDA NIH HHS/United States GR - U01 DA041148/DA/NIDA NIH HHS/United States GR - U01 DA041156/DA/NIDA NIH HHS/United States GR - U01 DA041174/DA/NIDA NIH HHS/United States GR - U24 DA041123/DA/NIDA NIH HHS/United States GR - U24 DA041147/DA/NIDA NIH HHS/United States GR - U01 DA050987/DA/NIDA NIH HHS/United States GR - U01 DA050988/DA/NIDA NIH HHS/United States GR - U01 DA050989/DA/NIDA NIH HHS/United States GR - U01 DA051018/DA/NIDA NIH HHS/United States GR - U01 DA051037/DA/NIDA NIH HHS/United States GR - U01 DA051038/DA/NIDA NIH HHS/United States GR - U01 DA051039/DA/NIDA NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20250726 PL - Netherlands TA - Am J Prev Med JT - American journal of preventive medicine JID - 8704773 RN - 3G6A5W338E (Caffeine) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Prenatal Exposure Delayed Effects/epidemiology MH - Adolescent MH - Longitudinal Studies MH - Body Mass Index MH - Male MH - Child MH - *Adiposity MH - *Pediatric Obesity/epidemiology/etiology MH - Caffeine/adverse effects MH - *Substance-Related Disorders EDAT- 2025/07/29 00:58 MHDA- 2025/10/25 00:30 CRDT- 2025/07/28 19:40 PHST- 2025/03/01 00:00 [received] PHST- 2025/07/17 00:00 [revised] PHST- 2025/07/17 00:00 [accepted] PHST- 2025/10/25 00:30 [medline] PHST- 2025/07/29 00:58 [pubmed] PHST- 2025/07/28 19:40 [entrez] AID - S0749-3797(25)00488-X [pii] AID - 10.1016/j.amepre.2025.107997 [doi] PST - ppublish SO - Am J Prev Med. 2025 Nov;69(5):107997. doi: 10.1016/j.amepre.2025.107997. Epub 2025 Jul 26. PMID- 40715989 OWN - NLM STAT- MEDLINE DCOM- 20250927 LR - 20261010 IS - 1179-2035 (Electronic) IS - 0112-1642 (Linking) VI - 55 IP - 9 DP - 2025 Sep TI - Psychometric Properties of Physical Activity Questionnaires for Children and Adolescents: An Updated Systematic Review. PG - 2225-2301 LID - 10.1007/s40279-025-02270-x [doi] AB - BACKGROUND: Questionnaires remain the most feasible method for large-scale physical activity (PA) surveillance. However, previous systematic reviews concluded that existing questionnaires had unsatisfactory psychometric properties. OBJECTIVES: This systematic review aimed to summarize and evaluate the measurement properties of self- and proxy-reported physical activity (PA) measures in children and adolescents published between 2018 and July 2024, thereby updating a previous review. This review also aimed to recommend the best available questionnaire(s) for young children (age < 6 years), children (age >/= 6 to < 12 years), and adolescents (age >/= 12 to < 18 years). METHODS: The COnsensus-based Standards for the Selection of Health Measurement INstruments (COSMIN) Guidelines for Systematic Reviews of Patient-Reported Outcome Measures were followed for conducting and reporting this systematic review. PubMed, EMBASE, and SPORTDiscus databases were searched for papers published between 2018 and July 2024. The peer-reviewed papers were included if published in Arabic, Chinese, Czech, English, French, Hindi, Nepali, Portuguese, Spanish, Swedish or Thai and assessed at least one of the measurement properties of self- or proxy-reported PA measures in young children, children, and adolescents. Papers were excluded if they measured PA with interview or diary or reported construct validity against non-PA measures (e.g., body mass index). The results of studies from the previous systematic review that reported test-retest reliability and construct validity of the questionnaires included in this systematic review were added to the pooled qualitative analyses and meta-analyses. RESULTS: A total of 106 papers were included which reported 177 studies related to content validity (n = 31), construct validity including hypotheses testing (n = 80), test-retest reliability (n = 65), and responsiveness (n = 1) of 71 questionnaires. None of the included questionnaires met the COSMIN criteria for sufficient content validity. Questionnaires with satisfactory construct validity (correlation r >/= 0.4) were found in young children (n = 2; e.g., the Outdoor Playtime Recall), children (n = 2; e.g., Self-rating Scale of Physical Activity Intensity for Preschool Children), and adolescents (n = 8; e.g., the Spanish version of Physical Activity Unit 7 Item Screener, the Czech version of Youth Activity Profile). Questionnaires with sufficient test-retest reliability (>/= 0.7) were found in young children (n = 2; e.g., the Movement Behaviour Questionnaire for Baby and Children), children (n = 3; e.g., Diet and Physical Activity Behaviors in the Feel4Diabetes Study), and adolescents (n = 5; e.g., the 24-Hour Movement Behavior Questionnaire). The Physical Activity Questionnaire for older Children and Adolescents had sufficient test-retest reliability based on pooled qualitative analysis and meta-analyses. The best available questionnaires were the Outdoor Playtime Recall (for young children) and the Physical Activity Questionnaire for Older Children and Adolescents for children and adolescents. CONCLUSION: This systematic review update did not identify a PA questionnaire that met COSMIN standards for both construct validity and test-retest reliability, partly due to the low methodological quality of the studies. Researchers should improve the methodological rigor of future psychometric studies, particularly for content validity, by adopting standardized guidelines (e.g., COSMIN). We also recommend: (1) using comparator tools that have demonstrated reliable measurement properties in populations similar to the target group; (2) formulating hypotheses in advance to confirm construct validity; (3) selecting appropriate intervals between test and retest and ensuring consistent test conditions; and (4) providing evidence of PA stability between test and retest. Lastly, when developing questionnaires to measure total PA, researchers should include all relevant domains of PA and assess their relevance during the content validation process. CI - (c) 2025. The Author(s), under exclusive licence to Springer Nature Switzerland AG. FAU - Rostami Haji Abadi, Mahdi AU - Rostami Haji Abadi M AD - Faculty of Health Sciences, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada. FAU - Kwaghbo, Nguden AU - Kwaghbo N AD - Faculty of Health Sciences, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada. FAU - Onyeso, Ogochukwu Kelechi AU - Onyeso OK AD - Faculty of Health Sciences, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada. FAU - Sadia, Farzana AU - Sadia F AD - Faculty of Health Sciences, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada. FAU - Benavides Castro, Judy Katterine AU - Benavides Castro JK AD - School of Medicine, Universidad de Los Andes, Cra 1 18 feminine-12, Bogota, Colombia. FAU - Silva, Diego Augusto Santos AU - Silva DAS AD - Department of Physical Education, Sports Center, Federal University of Santa Catarina, Florianopolis, Santa Catarina, 88040-900, Brazil. FAU - Yan, Yiping AU - Yan Y AD - School of Physical Education, Shanghai University of Sport, Yangpu District, Shanghai, 200438, China. FAU - Shen, Yangyang AU - Shen Y AD - School of Physical Education, Shanghai University of Sport, Yangpu District, Shanghai, 200438, China. FAU - Hamrik, Zdenek AU - Hamrik Z AD - Faculty of Physical Culture, Palacky University Olomouc, Tr. Miru 117, 779 00, Olomouc, Czech Republic. FAU - Sarmiento, Olga L AU - Sarmiento OL AD - School of Medicine, Universidad de Los Andes, Cra 1 18 feminine-12, Bogota, Colombia. FAU - Liu, Yang AU - Liu Y AD - School of Physical Education, Shanghai University of Sport, Yangpu District, Shanghai, 200438, China. FAU - Tremblay, Mark S AU - Tremblay MS AD - Healthy Active Living and Obesity Research Group, CHEO Research Institute, Ottawa, ON, K1H 8L1, Canada. AD - Department of Pediatrics, University of Ottawa, Ottawa, ON, K1H 8L1, Canada. FAU - Larouche, Richard AU - Larouche R AUID- ORCID: 0000-0002-8850-6895 AD - Faculty of Health Sciences, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada. richard.larouche@uleth.ca. LA - eng GR - PJT 183705/CIHR/Canada GR - ECP 184184/CIHR/Canada GR - G00004116/Prentice Institute for Global Population and Economy/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Systematic Review DEP - 20250725 PL - New Zealand TA - Sports Med JT - Sports medicine (Auckland, N.Z.) JID - 8412297 SB - IM MH - Humans MH - Child MH - *Psychometrics MH - *Exercise/psychology MH - Adolescent MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Self Report MH - Child, Preschool COIS- Declarations. Funding: The study received funding from the Canadian Institutes of Health Research (Grants # PJT 183705 and ECP 184184) and the Prentice Institute for Global Population and Economy (Grant # G00004116). Conflict of Interest: All authors declare that they have no conflict of interest relevant to the content of this article. Availability of Data and Material: Data available upon request. Authors' Contributions: MR, RL, and MT conceived the study idea and design. MR and RL led the screening, data extraction, methodological quality assessments, questionnaire evidence ratings and manuscript editing. FS, NK, HOM, OKO, YL, ZH, and DASS engaged in screening and YY, YS, JB, ZH, and DASS assisted with data extraction. MR, RL, OKO, and JB performed the methodological quality assessments and questionnaire evidence ratings. MR wrote the original manuscript, and all co-authors provided critical feedback and comments on the manuscript and read and approved the final version. EDAT- 2025/07/29 04:06 MHDA- 2025/09/27 12:35 CRDT- 2025/07/27 12:07 PHST- 2025/06/17 00:00 [accepted] PHST- 2025/09/27 12:35 [medline] PHST- 2025/07/29 04:06 [pubmed] PHST- 2025/07/27 12:07 [entrez] AID - 10.1007/s40279-025-02270-x [pii] AID - 10.1007/s40279-025-02270-x [doi] PST - ppublish SO - Sports Med. 2025 Sep;55(9):2225-2301. doi: 10.1007/s40279-025-02270-x. Epub 2025 Jul 25. PMID- 40715980 OWN - NLM STAT- Publisher LR - 20250727 IS - 1573-3432 (Electronic) IS - 0162-3257 (Linking) DP - 2025 Jul 26 TI - Sleep Disturbances and Dietary Habits in Autism: A Comparative Analysis. LID - 10.1007/s10803-025-06964-z [doi] AB - This study investigates dietary patterns and sleep quality in children and adolescents on the autism spectrum, compared to non-autistic peers. It explores the relationship between dietary habits and sleep quality, aiming to identify modifiable factors that could enhance well-being in ASD individuals. A cross-sectional case-control study was conducted with 158 participants on the autism spectrum and 77 non-autistic individuals aged 6-17 years in Spain. Dietary patterns were assessed using a validated food frequency questionnaire, while sleep quality was measured with the Children's Sleep Habits Questionnaire (CSHQ-SP) and Pittsburgh Sleep Quality Index (PSQI). Statistical analyses, including non-parametric tests and Spearman's correlation, were performed to examine differences and associations. Children on the autism spectrum displayed higher sugar intake and lower consumption of fruits and vegetables compared to non-autistic peers. ASD adolescents consumed more sugary beverages, with less pronounced differences in other food categories. Sleep quality was significantly poorer in the ASD group across all age cohorts, characterized by increased sleep latency, parasomnias, and daytime dysfunction. Positive associations were found between fruit and vegetable intake and improved sleep quality in ASD children. Unexpectedly, adolescents on the autism spectrum showed a complex relationship between sugar consumption and sleep quality, indicating potential short-term benefits but long-term risks. This study highlights the interplay between diet and sleep quality in ASD populations. Interventions promoting healthier eating habits, such as increased fruit and vegetable intake and reduced sugar consumption, could improve sleep outcomes and overall well-being in this vulnerable population. CI - (c) 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Martinez-Villamea, Silvia AU - Martinez-Villamea S AUID- ORCID: 0000-0003-1357-4946 AD - Department of Nursing and Physiotherapy, Universidad de Leon, Campus of Vegazana s/n, 24071, Leon, Spain. smartv03@estudiantes.unileon.es. AD - Instituto de Investigacion Biosanitaria de Asturias (ISPA), Critical Care Research Group, Avenida Hospital Universitario s/n, 33011, Oviedo, Spain. smartv03@estudiantes.unileon.es. FAU - Prada-Garcia, Camino AU - Prada-Garcia C AD - Department of Preventive Medicine and Public Health, University of Valladolid, 47005, Valladolid, Valladolid, Spain. AD - Dermatology Service, Complejo Asistencial Universitario de Leon, 24008, Leon, Spain. FAU - Benitez-Andrades, Jose Alberto AU - Benitez-Andrades JA AD - ALBA Research Group, Department of Electric, Systems and Automatics Engineering, Universidad de Leon, Campus of Vegazana s/n, 24071, Leon, Spain. AD - Instituto de Investigacion Biosanitaria de Leon (IBIOLEON), Calle Altos de Nava, s/n, 24008, Leon, Leon, Spain. FAU - Quiroga-Sanchez, Enedina AU - Quiroga-Sanchez E AD - SALBIS Research Group, Department of Nursing and Physiotherapy, Universidad de Leon, Campus of Ponferrada s/n, 24400, Ponferrada, Spain. FAU - Garcia-Fernandez, Ruben AU - Garcia-Fernandez R AD - SALBIS Research Group, Department of Nursing and Physiotherapy, Universidad de Leon, Campus of Ponferrada s/n, 24400, Ponferrada, Spain. AD - Nursing Research, Innovation and Development Centre of Lisbon, Lisbon, Portugal. AD - El Bierzo Health Care Management (GASBI), Fuentesnuevas, 24404, Ponferrada, Leon, Spain. FAU - Arias-Ramos, Natalia AU - Arias-Ramos N AD - SALBIS Research Group, Department of Nursing and Physiotherapy, Universidad de Leon, Campus of Ponferrada s/n, 24400, Ponferrada, Spain. AD - El Bierzo Health Care Management (GASBI), Fuentesnuevas, 24404, Ponferrada, Leon, Spain. LA - eng PT - Journal Article DEP - 20250726 PL - United States TA - J Autism Dev Disord JT - Journal of autism and developmental disorders JID - 7904301 SB - IM OTO - NOTNLM OT - Autism spectrum disorder (ASD) OT - Children and adolescents OT - Dietary patterns OT - Gut-brain axis OT - Neurodevelopment OT - Sleep quality COIS- Declarations. Competing Interests: The authors have no relevant financial or non-financial interests to disclose. Ethical Approval: The study received ethical approval from the Research Ethics Committee of the University of Leon (ETICA-ULE-043-2022) and adhered to the principles outlined in the Declaration of Helsinki. All participants received informed consent documents specifying that data would be used exclusively for research purposes, with strict adherence to anonymity and confidentiality as required by Spanish law. Consent to Participate: Informed consent was obtained from all individual participants included in the study. Consent for Publication: There is no individual data from the participants in the manuscript. EDAT- 2025/07/29 04:06 MHDA- 2025/07/29 04:06 CRDT- 2025/07/27 12:07 PHST- 2025/07/01 00:00 [accepted] PHST- 2025/07/29 04:06 [medline] PHST- 2025/07/29 04:06 [pubmed] PHST- 2025/07/27 12:07 [entrez] AID - 10.1007/s10803-025-06964-z [pii] AID - 10.1007/s10803-025-06964-z [doi] PST - aheadofprint SO - J Autism Dev Disord. 2025 Jul 26. doi: 10.1007/s10803-025-06964-z. PMID- 40720437 OWN - NLM STAT- MEDLINE DCOM- 20250729 LR - 20251029 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 7 DP - 2025 TI - The validity of mid-upper arm circumference as an indicator of underweight, overweight and obesity adults in Bangladesh. PG - e0327499 LID - 10.1371/journal.pone.0327499 [doi] LID - e0327499 AB - BACKGROUND: Mid-upper-arm circumference (MUAC), as a simple measurement, is an effective alternative to body mass index (BMI) for resource-limited countries such as Bangladesh. The present study aimed to investigate the age- and sex-specific MUAC cut-off points as screening tools for underweight, overweight and obesity in Bangladesh. SUBJECT AND METHODS: A nationally representative dataset (BDHS-2017/18) comprising of 12,962 adults individuals (females: 56.5%, mean age: 39.5+/-16.0 Years, BMI: 22.4+/-4.1 kg/m2 and MUAC: 27.4+/-3.1 cm) was analyzed. BMI was categorized as underweight (BMI <18.5 kg/m2), overweight (BMI: 23 kg/m2), or obese (BMI: >/=27.5 kg/m2). A receiver operating characteristic curve analysis was conducted to determine the optimal MUAC cut-off, based on Youden Index, for underweight, overweight, and obese individuals. Multiple linear regression analysis was performed, adjusting for age and sex, to explore age and sex-specific changes in the association between MUAC and BMI. Restricted cubic spline and binary logistic regression analyses were performed to evaluate the risk of underweight, overweight and obesity among different MUAC quartiles. RESULTS: For males, MUAC cut-offs were /= 28.5 cm for overweight (AUC: 84.8%, sensitivity: 77.6%, specificity: 76.9%), and >/=29.5 cm for obesity (AUC: 89.4%, sensitivity: 87.8%, specificity: 76.6%) in younger and middle-aged individuals; older males had cut-offs of /= 27.5 cm, and >/=29.5 cm respectively. For females, the cut-offs were lower: /= 27.5 cm for overweight in younger, and >/=26.5 cm in middle-aged and older; and >/=28.5 cm for obesity in younger and middle-aged, and >/=27.5 cm in older. The MUAC-BMI correlation was strong (R = 0.69, P < 0.001), stronger in males (R = 0.75) than females (R = 0.69). The MUAC cut-off for underweight, overweight, and obesity slightly decreased with age in both sexes. CONCLUSION: Age- and sex-specific MUAC cut-offs are effective for screening underweight, overweight and obesity in Bangladesh. CI - Copyright: (c) 2025 Rahman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Rahman, Sheikh Arafat AU - Rahman SA AUID- ORCID: 0009-0003-6886-9589 AD - Department of Applied Nutrition and Food Technology, Islamic University, Kushtia, Bangladesh. FAU - Kabir, Md Humayan AU - Kabir MH AUID- ORCID: 0009-0000-4538-4683 AD - Department of Applied Nutrition and Food Technology, Islamic University, Kushtia, Bangladesh. FAU - Rahman, Shaikh Shahinur AU - Rahman SS AD - Department of Applied Nutrition and Food Technology, Islamic University, Kushtia, Bangladesh. FAU - Kamruzzaman, Md AU - Kamruzzaman M AUID- ORCID: 0000-0001-5138-2182 AD - Department of Applied Nutrition and Food Technology, Islamic University, Kushtia, Bangladesh. LA - eng PT - Journal Article DEP - 20250728 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM EIN - PLoS One. 2025 Oct 29;20(10):e0335763. doi: 10.1371/journal.pone.0335763. PMID: 41160582 MH - Humans MH - Female MH - Male MH - Adult MH - Bangladesh/epidemiology MH - Middle Aged MH - *Obesity/diagnosis/epidemiology/pathology MH - *Thinness/diagnosis/epidemiology MH - *Arm/anatomy & histology MH - Body Mass Index MH - *Overweight/diagnosis/epidemiology MH - Young Adult MH - Adolescent MH - ROC Curve MH - Aged MH - Anthropometry/methods PMC - PMC12303288 COIS- The authors have declared that no competing interests exist. EDAT- 2025/07/28 19:03 MHDA- 2025/07/30 00:30 PMCR- 2025/07/28 CRDT- 2025/07/28 13:42 PHST- 2025/04/10 00:00 [received] PHST- 2025/06/16 00:00 [accepted] PHST- 2025/07/30 00:30 [medline] PHST- 2025/07/28 19:03 [pubmed] PHST- 2025/07/28 13:42 [entrez] PHST- 2025/07/28 00:00 [pmc-release] AID - PONE-D-25-18917 [pii] AID - 10.1371/journal.pone.0327499 [doi] PST - epublish SO - PLoS One. 2025 Jul 28;20(7):e0327499. doi: 10.1371/journal.pone.0327499. eCollection 2025. PMID- 40720140 OWN - NLM STAT- MEDLINE DCOM- 20250902 LR - 20260915 IS - 2168-6211 (Electronic) IS - 2168-6203 (Print) IS - 2168-6203 (Linking) VI - 179 IP - 9 DP - 2025 Sep 1 TI - Global Prevalence of Hypertension in Children and Adolescents Younger Than 19 Years: A Systematic Review and Meta-Analysis. PG - 987-999 LID - 10.1001/jamapediatrics.2025.2206 [doi] AB - IMPORTANCE: Pediatric hypertension predicts adult hypertension and early target organ damage, yet global prevalence estimates based on different diagnostic principles remain scarce. OBJECTIVE: To estimate global pediatric hypertension prevalence according to different diagnostic principles. DATA SOURCES: Several databases, including PubMed, Web of Science, Embase, the China National Knowledge Infrastructure (CNKI), and the Wanfang Database, were systematically searched from inception to July 7, 2024. STUDY SELECTION: Studies were included if they were original investigations in children and adolescents younger than 19 years, represented the general population, and provided data on hypertension prevalence. DATA EXTRACTION AND SYNTHESIS: Data screening and extraction were performed independently by 2 authors. A random-effects model was used to estimate prevalence. Temporal trends, as well as regional and population differences, were explored. Subgroup analyses and meta-regression analyses were performed to identify sources of heterogeneity. Publication bias was assessed by funnel plots and the Egger test. MAIN OUTCOMES AND MEASURES: The primary outcome was pediatric hypertension, categorized into sustained hypertension (persistent diagnosis confirmed on >/=3 separate occasions) and occasional hypertension (initial diagnosis determined by blood pressure measurements on a single screening visit). RESULTS: A total of 271 studies involving 16 328 individuals with sustained hypertension, 538 735 individuals with occasional hypertension, and 3 609 665 children and adolescents were included for analysis. The global prevalence of pediatric hypertension was 3.89% (95% CI, 3.27%-4.62%) for sustained hypertension and 11.85% (95% CI, 10.98%-12.75%) for occasional hypertension. Increasing trends with time were observed, with an annual increase of 7.20% (95% CI, 4.16%-10.32%; P < .001) from 2006 to 2021 for sustained hypertension and an estimated annual percentage change of 0.33% (95% CI, 0.10%-0.56%) between 1987 and 2022 for occasional hypertension. Additionally, significant differences were observed across geographical regions and population characteristics for the prevalence of pediatric hypertension. Children and adolescents with obesity or overweight (16.35% and 6.79% vs 2.57% [normal weight] for sustained hypertension) had significantly higher prevalence of hypertension. CONCLUSIONS AND RELEVANCE: This systematic review and meta-analysis indicates substantial variations in the global prevalence of sustained and occasional hypertension, highlighting the importance of measurements on multiple occasions to enhance reliability. Notable differences in prevalence across individuals' body mass index values highlight the necessity for targeted interventions to promote healthy lifestyles. FAU - Ruan, Xiaorui AU - Ruan X AD - Department of Epidemiology and Health Statistics, School of Public Health, Kunming Medical University, Kunming, China. AD - Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China. FAU - Zhu, Anji AU - Zhu A AD - The Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth College, Lebanon, New Hampshire. FAU - Wang, Tingting AU - Wang T AD - Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China. FAU - Sun, Mengting AU - Sun M AD - Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China. FAU - Chen, Kebin AU - Chen K AD - Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China. FAU - Luo, Manjun AU - Luo M AD - Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China. FAU - Li, Zhanwen AU - Li Z AD - Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China. FAU - Zou, Qi AU - Zou Q AD - Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China. FAU - Chen, Ye AU - Chen Y AD - Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China. FAU - Peng, Yuan AU - Peng Y AD - Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China. FAU - Qin, Jiabi AU - Qin J AD - Department of Epidemiology and Health Statistics, School of Public Health, Kunming Medical University, Kunming, China. AD - Yunnan Key Laboratory of Cross-Border Infectious Disease Prevention and New Drug Development, Kunming, China. AD - Yunnan Provincial Key Laboratory of Public Health and Biosafety, Kunming, China. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review PL - United States TA - JAMA Pediatr JT - JAMA pediatrics JID - 101589544 SB - IM CIN - JAMA Pediatr. 2025 Sep 1;179(9):952-954. doi: 10.1001/jamapediatrics.2025.2203. PMID: 40720115 MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Global Health/statistics & numerical data MH - *Hypertension/epidemiology/diagnosis MH - Prevalence PMC - PMC12305442 COIS- Conflict of Interest Disclosures: None reported. EDAT- 2025/07/28 19:01 MHDA- 2025/09/02 14:44 PMCR- 2026/07/28 CRDT- 2025/07/28 11:34 PHST- 2025/09/02 14:44 [medline] PHST- 2025/07/28 19:01 [pubmed] PHST- 2025/07/28 11:34 [entrez] PHST- 2026/07/28 00:00 [pmc-release] AID - 2836899 [pii] AID - poi250036 [pii] AID - 10.1001/jamapediatrics.2025.2206 [doi] PST - ppublish SO - JAMA Pediatr. 2025 Sep 1;179(9):987-999. doi: 10.1001/jamapediatrics.2025.2206. PMID- 40719392 OWN - NLM STAT- MEDLINE DCOM- 20250729 LR - 20260724 IS - 2044-8287 (Electronic) IS - 1359-107X (Linking) VI - 30 IP - 3 DP - 2025 Sep TI - Sleep, sedentary behaviour, physical activity and health-related quality of life in children and adolescents: A systematic review. PG - e70004 LID - 10.1111/bjhp.70004 [doi] AB - PURPOSE: This systematic review summarizes the associations between sleep, sedentary behaviour and physical activity and HRQoL in children and adolescents. METHODS: PubMed, Embase, PsycINFO and SPORTDiscus were searched from inception until April 2023. Studies conducted in healthy children and adolescents, aged 60 min/day) and sports participation. Nevertheless, high-quality studies are necessary in the future. REGISTRATION: The protocol of this systematic review was registered in PROSPERO (CRD42023414970). CI - (c) 2025 British Psychological Society. FAU - Ferreira, Gabriela AU - Ferreira G AUID- ORCID: 0000-0003-0993-5614 AD - Research Centre on Child Studies, University of Minho, Braga, Portugal. FAU - Redondo-Tebar, Andres AU - Redondo-Tebar A AD - Social and Health Research Center, Universidad de Castilla-La Mancha, Cuenca, Spain. AD - Facultad de Enfermeria, Universidad de Castilla-La Mancha, Ciudad Real, Spain. FAU - Goncalves, Joao Pedro AU - Goncalves JP AD - Research Centre on Child Studies, University of Minho, Braga, Portugal. FAU - Sousa-Sa, Eduarda AU - Sousa-Sa E AD - Liberal Arts Department, American University of the Middle East, Egaila, Kuwait. FAU - Oliveira, Olena AU - Oliveira O AD - EPIUnit - Institute of Public Health, University of Porto, Porto, Portugal. AD - Laboratory for Integrative and Translational Research in Population Health (ITR), University of Porto, Porto, Portugal. FAU - Lopes, Luis AU - Lopes L AD - Research Centre in Physical Activity, Health and Leisure. Faculty of Sport, University of Porto, Porto, Portugal. FAU - Santos, Rute AU - Santos R AD - Research Centre on Child Studies, University of Minho, Braga, Portugal. AD - Institute of Education, University of Minho, Braga, Portugal. LA - eng GR - Fundacao para a Ciencia e a Tecnologia/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Systematic Review PL - England TA - Br J Health Psychol JT - British journal of health psychology JID - 9605409 SB - IM MH - Humans MH - *Sedentary Behavior MH - Adolescent MH - Child MH - *Exercise/physiology MH - *Quality of Life MH - *Sleep/physiology MH - Child, Preschool MH - Screen Time MH - Young Adult MH - *Sleep Quality MH - Sports MH - Male MH - Female MH - Cross-Sectional Studies OTO - NOTNLM OT - adolescents OT - children OT - health-related quality of life OT - physical activity OT - sedentary behaviour OT - sleep EDAT- 2025/07/28 19:00 MHDA- 2025/07/29 18:31 CRDT- 2025/07/28 08:34 PHST- 2025/02/24 00:00 [received] PHST- 2025/06/26 00:00 [accepted] PHST- 2025/07/29 18:31 [medline] PHST- 2025/07/28 19:00 [pubmed] PHST- 2025/07/28 08:34 [entrez] AID - 10.1111/bjhp.70004 [doi] PST - ppublish SO - Br J Health Psychol. 2025 Sep;30(3):e70004. doi: 10.1111/bjhp.70004. PMID- 40719300 OWN - NLM STAT- MEDLINE DCOM- 20250929 LR - 20250929 IS - 1525-6073 (Electronic) IS - 0742-0528 (Linking) VI - 42 IP - 9 DP - 2025 Sep TI - Morning lark or night owl? Understanding the role of sleep quality and chronotype on dietary quality and hedonic hunger in university students. PG - 1194-1206 LID - 10.1080/07420528.2025.2536519 [doi] AB - The role of sleep quality and chronotype on diet quality and hedonic hunger has not been fully clarified. This cross-sectional study aimed to examine these associations and included a total of 2124 participants (1459 women and 665 men; mean age 21.3 +/- 2.5 years). Data were collected using validated instruments: the Morningness-Eveningness Questionnaire (MEQ) to assess chronotype, the Pittsburgh Sleep Quality Index (PSQI) for sleep quality, the Power of Food Scale (PFS) and Turkish Palatable Eating Motives Scale (T-PEMS) to evaluate hedonic hunger, and a 24-hour dietary recall to determine diet quality via the Healthy Eating Index-2020 (HEI-2020). Anthropometric measurements were obtained by the researcher. Results indicated that men had significantly higher body mass index (BMI) (p < 0.001) and were more likely to exhibit an evening chronotype (p = 0.023), whereas women demonstrated higher MEQ and T-PEMS scores (p < 0.001). Poor sleep quality was prevalent in 80.6% of participants and was associated with increased T-PEMS (p < 0.001). Evening chronotypes exhibited significantly poorer sleep quality, higher T-PEMS scores, and lower HEI-2020 scores compared to morning types (p < 0.001). These findings may indicate that both sleep patterns and circadian preferences can play a significant role in shaping diet quality among university students. FAU - Dumlu Bilgin, Gozde AU - Dumlu Bilgin G AUID- ORCID: 0000-0001-6385-0190 AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Yeditepe University, Istanbul, Turkiye. FAU - Kavsara, Hasan Kaan AU - Kavsara HK AUID- ORCID: 0000-0002-0322-0397 AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Yeditepe University, Istanbul, Turkiye. FAU - Usta Ulutas, Pinar AU - Usta Ulutas P AUID- ORCID: 0000-0001-8760-0233 AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Yeditepe University, Istanbul, Turkiye. AD - Institute of Health Sciences, Department of Nutrition and Dietetics, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkiye. FAU - Aray, Yaren AU - Aray Y AUID- ORCID: 0000-0002-2258-759X AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Esenyurt University, Istanbul, Turkiye. FAU - Gunduz, Irem Derin AU - Gunduz ID AUID- ORCID: 0009-0006-9648-0935 AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Yeditepe University, Istanbul, Turkiye. FAU - Koc, Melike AU - Koc M AUID- ORCID: 0009-0005-0993-7339 AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Yeditepe University, Istanbul, Turkiye. FAU - Kurt, Cagla AU - Kurt C AUID- ORCID: 0009-0005-3045-0103 AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Yeditepe University, Istanbul, Turkiye. FAU - Kucukomeroglu, Esra AU - Kucukomeroglu E AUID- ORCID: 0009-0005-5697-0211 AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Yeditepe University, Istanbul, Turkiye. LA - eng PT - Journal Article DEP - 20250728 PL - England TA - Chronobiol Int JT - Chronobiology international JID - 8501362 SB - IM MH - Humans MH - Female MH - Male MH - *Circadian Rhythm/physiology MH - Young Adult MH - Students MH - *Sleep Quality MH - Cross-Sectional Studies MH - Universities MH - Adult MH - *Feeding Behavior/physiology MH - *Hunger/physiology MH - *Sleep/physiology MH - Surveys and Questionnaires MH - *Diet MH - Body Mass Index MH - Adolescent MH - Chronotype OTO - NOTNLM OT - University students OT - chronotype OT - diet quality OT - hedonic hunger OT - sleep quality EDAT- 2025/07/28 19:00 MHDA- 2025/09/29 13:18 CRDT- 2025/07/28 08:03 PHST- 2025/09/29 13:18 [medline] PHST- 2025/07/28 19:00 [pubmed] PHST- 2025/07/28 08:03 [entrez] AID - 10.1080/07420528.2025.2536519 [doi] PST - ppublish SO - Chronobiol Int. 2025 Sep;42(9):1194-1206. doi: 10.1080/07420528.2025.2536519. Epub 2025 Jul 28. PMID- 40715668 OWN - NLM STAT- MEDLINE DCOM- 20260629 LR - 20260813 IS - 1556-3308 (Electronic) IS - 1094-3412 (Print) IS - 1094-3412 (Linking) VI - 53 IP - 3 DP - 2026 Jul TI - Comparing Questionnaires for Assessing Orthorexic Thoughts and Behaviors in College Students. PG - 404-428 LID - 10.1007/s11414-025-09957-z [doi] AB - Mindful eating (ME) is becoming increasingly popular as a method of changing problematic eating behaviors, including orthorexic (ON) thoughts and behaviors. Simultaneously, the psychometric flaws of commonly used questionnaires for assessing ON thoughts and behaviors limit the potential of exploring their association with ME and diet quality. The study aimed to (a) assess the intensity of ON thoughts and behaviors; (b) evaluate the associations between ON thoughts and behaviors, ME, and diet quality; and (c) compare ORTO-R with ORTO-15 and its shortened versions and PL-DOS. Data were collected from a sample of 478 college students through a cross-sectional study conducted in 2021 across eighteen universities in Poland. Students completed the ORTO-R, ORTO-15, Dusseldorf Orthorexia Scale (PL-DOS), Mindful Eating Scale (MES), and Dietary Habits and Nutrition Beliefs Questionnaire (KomPAN). ORTO-15 and its shortened versions correlated at least highly positively with each other for both sexes, as did ORTO-R and PL-DOS. Positive correlations were found between ORTO-15 and its shortened versions and such mindful eating behaviors as act with awareness as well as awareness for females and/or males. Meanwhile, ORTO-R correlated negatively with act with awareness and acceptance for females and/or males. In addition, PL-DOS correlated negatively with awareness and acceptance for females and/or males. An increase in the intensity of ON thoughts and behaviors measured by almost all questionnaires was associated with an increase in the intensity of beneficial dietary characteristics for health (higher the "Pro-Healthy Diet Index"-pHDI, and the "Diet Quality Index"-DQI) and a decrease in the intensity of harmful dietary characteristics for health (lower the "Non-Healthy Diet Index"-nHDI). Overall, ORTO-R and PL-DOS proved to be the most effective questionnaires for distinguishing eating behaviors in the context of orthorexic thoughts and behaviors, but only for ME. The results may suggest that ME practices may be associated with reduced ON thoughts and behaviors. However, limitations of the study, for example, a sample of college students, a non-randomly selected of sample, a cross-sectional design of the study, and an imbalanced biological sex ratio, make it much more difficult to generalize the results. CI - (c) 2025. The Author(s). FAU - Plichta, Marta AU - Plichta M AUID- ORCID: 0000-0002-3347-6086 AD - Department of Food Market and Consumer Research, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (SGGW-WULS), Nowoursynowska St. 159C, 02-776, Warsaw, Poland. marta_plichta@sggw.edu.pl. FAU - Rogoza, Radoslaw AU - Rogoza R AD - Department of Human Sciences, University of Economics and Human Sciences in Warsaw, Okopowa St. 59, 01-043, Warsaw, Poland. LA - eng GR - DEC-2019/35/N/NZ7/00307/Narodowym Centrum Nauki/ PT - Comparative Study PT - Journal Article DEP - 20250725 PL - United States TA - J Behav Health Serv Res JT - The journal of behavioral health services & research JID - 9803531 SB - IM MH - Humans MH - Female MH - *Students/psychology MH - Male MH - Cross-Sectional Studies MH - Surveys and Questionnaires/standards MH - Universities MH - *Feeding Behavior/psychology MH - Young Adult MH - Psychometrics MH - Adolescent MH - Poland MH - Adult MH - *Feeding and Eating Disorders/psychology/diagnosis MH - *Health Behavior PMC - PMC13315514 OTO - NOTNLM OT - College students OT - Diet quality OT - Mindful eating OT - ORTO; PL-DOS OT - Orthorexic thoughts and behaviors OT - Questionnaires comparison COIS- Declarations. Institutional Review Board Statement: The study protocol was approved by the Ethics Committee of the Faculty of Human Nutrition and Consumer Science, Warsaw University of Life Sciences (Resolution number 45/2017). Informed Consent Statement: Informed consent was obtained from all subjects involved in the study. Conflict of interest: The authors declare no competing interests. EDAT- 2025/07/28 08:44 MHDA- 2026/06/29 12:33 PMCR- 2025/07/25 CRDT- 2025/07/27 11:54 PHST- 2025/06/18 00:00 [accepted] PHST- 2026/06/29 12:33 [medline] PHST- 2025/07/28 08:44 [pubmed] PHST- 2025/07/27 11:54 [entrez] PHST- 2025/07/25 00:00 [pmc-release] AID - 10.1007/s11414-025-09957-z [pii] AID - 9957 [pii] AID - 10.1007/s11414-025-09957-z [doi] PST - ppublish SO - J Behav Health Serv Res. 2026 Jul;53(3):404-428. doi: 10.1007/s11414-025-09957-z. Epub 2025 Jul 25. PMID- 40714584 OWN - NLM STAT- MEDLINE DCOM- 20250831 LR - 20260813 IS - 1873-7358 (Electronic) IS - 1471-0153 (Print) IS - 1471-0153 (Linking) VI - 58 DP - 2025 Aug TI - Preliminary evaluation of dim light melatonin onset as an indicator of nighttime eating in adolescents. PG - 102015 LID - S1471-0153(25)00080-7 [pii] LID - 10.1016/j.eatbeh.2025.102015 [doi] AB - Late sleep timing is associated with adverse eating and weight outcomes in adolescents. One possible behavioral mechanism may be nighttime eating: eating when melatonin levels are high disrupts glucose tolerance. Thus, we propose defining nighttime eating as eating after the onset of melatonin secretion (i.e., after the start of biological night). This exploratory study aimed to 1) validate use of an objective circadian marker of the start of biological night, dim light melatonin onset (DLMO), to define nighttime eating (eating before vs. after DLMO) and 2) examine whether nighttime eating is associated with metabolic markers. Adolescents (N = 68; 16-18y) completed one-week of actigraphy and one 24-h dietary recall in their natural environment during an observational phase. During a weeknight overnight laboratory visit, adolescents completed one assessment of DLMO via repeated saliva sampling. Adolescents were categorized according to the timing of their last naturalistic eating episode (on prior day) before (n = 48) vs. after DLMO (n = 20) and were compared on naturalistic dietary intake, physical activity, and BMI percentile using two-sample t-tests. Effect sizes are reported. Adolescents who ate after DLMO had greater total naturalistic caloric intake (d = 0.40), as well as lower BMI percentiles (d = 0.47) which may, in part, be explained by their higher levels of naturalistic weekly physical activity (d = 0.68). Future research should replicate these findings in larger samples and across multiple samplings of DLMO and dietary intake. Using DLMO to define nighttime eating may support future mechanistic research on excess energy intake/poor diet quality in adolescents. 244/250. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Chapa, Danielle A N AU - Chapa DAN AD - University of Pittsburgh, Department of Psychiatry, 3811 O'Hara Street, Pittsburgh, PA 15213, USA. Electronic address: iversonchapada@upmc.edu. FAU - Goldschmidt, Andrea B AU - Goldschmidt AB AD - University of Pittsburgh, Department of Psychiatry, 3811 O'Hara Street, Pittsburgh, PA 15213, USA. Electronic address: goldscha@pitt.edu. FAU - Kline, Christopher E AU - Kline CE AD - University of Pittsburgh, Department of Health and Human Development, 32 Oak Hill Court, Pittsburgh, PA 15261, USA. Electronic address: chriskline@pitt.edu. FAU - Kolko Conlon, Rachel P AU - Kolko Conlon RP AD - University of Pittsburgh, Department of Psychiatry, 3811 O'Hara Street, Pittsburgh, PA 15213, USA. Electronic address: kolkorp2@upmc.edu. FAU - Hasler, Brant P AU - Hasler BP AD - University of Pittsburgh, Department of Psychiatry, 3811 O'Hara Street, Pittsburgh, PA 15213, USA. Electronic address: haslerbp@upmc.edu. LA - eng GR - R01 DA044143/DA/NIDA NIH HHS/United States GR - T32 MH018269/MH/NIMH NIH HHS/United States PT - Journal Article DEP - 20250720 PL - United States TA - Eat Behav JT - Eating behaviors JID - 101090048 RN - JL5DK93RCL (Melatonin) SB - IM MH - Humans MH - Adolescent MH - *Melatonin/metabolism MH - Female MH - Male MH - *Feeding Behavior/physiology MH - *Circadian Rhythm/physiology MH - Saliva/chemistry/metabolism MH - *Eating/physiology MH - Sleep/physiology MH - Body Mass Index MH - Energy Intake/physiology MH - Actigraphy PMC - PMC13015261 MID - NIHMS2151478 OTO - NOTNLM OT - Adolescents OT - DLMO OT - Eating OT - Nighttime eating OT - Physical activity OT - Weight COIS- Declaration of competing interest The authors have no financial/personal interests to disclose that could affect their objectivity in the preparation of this manuscript. EDAT- 2025/07/28 08:44 MHDA- 2025/09/01 00:44 PMCR- 2026/03/25 CRDT- 2025/07/27 01:38 PHST- 2024/10/24 00:00 [received] PHST- 2025/07/16 00:00 [revised] PHST- 2025/07/16 00:00 [accepted] PHST- 2025/09/01 00:44 [medline] PHST- 2025/07/28 08:44 [pubmed] PHST- 2025/07/27 01:38 [entrez] PHST- 2026/03/25 00:00 [pmc-release] AID - S1471-0153(25)00080-7 [pii] AID - 10.1016/j.eatbeh.2025.102015 [doi] PST - ppublish SO - Eat Behav. 2025 Aug;58:102015. doi: 10.1016/j.eatbeh.2025.102015. Epub 2025 Jul 20. PMID- 40713991 OWN - NLM STAT- MEDLINE DCOM- 20251017 LR - 20251017 IS - 1096-0953 (Electronic) IS - 0013-9351 (Linking) VI - 285 IP - Pt 2 DP - 2025 Nov 15 TI - Impact of climate change on diarrhoea risk in low- and middle-income countries. PG - 122412 LID - S0013-9351(25)01664-0 [pii] LID - 10.1016/j.envres.2025.122412 [doi] AB - Diarrhoea remains a leading cause of mortality among children under five years of age, with over 99 % of deaths occurring in low- and middle-income countries. Poor water quality, inadequate sanitation, poverty, undernutrition, and limited healthcare access contribute to this lingering problem, together with emerging environmental stressors driven by climate change. We analysed long-term spatial relationships between environmental, socio-economic, and maternal/child factors using Demographic and Health Surveys and WorldClim data across eight South and Southeast Asian countries (n = 66,545 clusters; 3,143,811 child-level observations). We employed boosted regression trees to assess variable importance across five thematic phases: socio-economic, maternal, child, climate, and combined. We selected variables based on biological plausibility, collinearity checks, and completeness. We addressed uncertainty through multiple imputation and stochastic resampling, and we evaluated model performance using cross-validation. The main predictors of diarrhoea incidence included annual temperature variability, precipitation in the wettest month, maternal education, and household size. Higher annual temperature range (30-40 degrees C) was associated with a approximately 39 % increase in diarrhoea probability, while lower precipitation in the wettest month (< 600 mm) increased risk by approximately 29 %, highlighting the role of drier conditions. We found that maternal education < 8 years increased diarrhoea probability by approximately 18 %, and household sizes exceeding six members increased it by approximately 9 %. Our findings emphasise the need for climate-resilient public-health policies that integrate social and environmental determinants of diarrhoea. Targeted interventions - including improved maternal education, water and sanitation infrastructure, and resource management in densely populated households - are necessary to mitigate diarrhoea risk in vulnerable regions under changing climate conditions. CI - Copyright (c) 2025 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Fatima, Syeda H AU - Fatima SH AD - Global Ecology | Partuyarta Ngadluku Wardli Kuu, College of Science and Engineering, Flinders University, Adelaide, South Australia, Australia; The Kids Research Institute Australia, Nedlands, Western Australia, Australia; Healthy Environments and Lives (HEAL) Global Research Centre, University of Canberra, Canberra, Australian Capital Territory, Australia. Electronic address: syeda.fatima@flinders.edu.au. FAU - Judge, Melinda A AU - Judge MA AD - The Kids Research Institute Australia, Nedlands, Western Australia, Australia; School of Mathematics and Statistics, University of Western Australia, Western Australia, Australia. FAU - Le Souef, Peter N AU - Le Souef PN AD - School of Medicine, University of Western Australia, Western Australia, Australia. FAU - Bradshaw, Corey J A AU - Bradshaw CJA AD - Global Ecology | Partuyarta Ngadluku Wardli Kuu, College of Science and Engineering, Flinders University, Adelaide, South Australia, Australia. LA - eng PT - Journal Article DEP - 20250724 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 SB - IM MH - *Diarrhea/epidemiology MH - *Climate Change MH - Humans MH - *Developing Countries MH - Child, Preschool MH - Infant MH - Socioeconomic Factors MH - Female OTO - NOTNLM OT - Boosted regression trees OT - Children OT - Climate change OT - DHS OT - Demographic and Health Surveys OT - Diarrhoea COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/07/28 08:45 MHDA- 2025/10/18 00:30 CRDT- 2025/07/27 01:19 PHST- 2024/12/18 00:00 [received] PHST- 2025/06/04 00:00 [revised] PHST- 2025/07/20 00:00 [accepted] PHST- 2025/10/18 00:30 [medline] PHST- 2025/07/28 08:45 [pubmed] PHST- 2025/07/27 01:19 [entrez] AID - S0013-9351(25)01664-0 [pii] AID - 10.1016/j.envres.2025.122412 [doi] PST - ppublish SO - Environ Res. 2025 Nov 15;285(Pt 2):122412. doi: 10.1016/j.envres.2025.122412. Epub 2025 Jul 24. PMID- 40712669 OWN - NLM STAT- MEDLINE DCOM- 20250907 LR - 20260524 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 215 DP - 2025 Nov 1 TI - Psychological predictors of eating Behavior: The role of maladaptive schemas and emotion regulation across BMI, gender, and age groups. PG - 108243 LID - S0195-6663(25)00396-4 [pii] LID - 10.1016/j.appet.2025.108243 [doi] AB - Disordered eating behaviors, including emotional and habitual overeating, are shaped by a complex interplay of psychological, demographic, and biological factors. While genetic influences such as FTO polymorphisms have been highlighted in previous research, emerging evidence points to the pivotal role of cognitive-emotional processes-particularly early maladaptive schemas (EMS) and emotion regulation difficulties-in the development and maintenance of unhealthy eating patterns. This study investigated how EMS, emotion regulation, and eating behaviors (emotional, habitual, and restrained eating) differ across body mass index (BMI), gender, and age in a large community-based adult sample. A total of 1500 participants aged 18-65, stratified by BMI (normal weight vs. overweight/obese), gender, and age group (younger vs. older adults), completed validated measures of EMS (Young Schema Questionnaire), emotion regulation difficulties (DERS), and eating behaviors (QERB). MANOVA, ANOVA, and cluster analyses were conducted. Individuals with overweight or obesity showed significantly higher levels of maladaptive schemas (e.g., Emotional Deprivation, Abandonment, Insufficient Self-Control), greater emotion regulation difficulties, and more frequent emotional and habitual overeating. Women and younger adults were especially vulnerable, reporting higher scores in emotional eating and emotion dysregulation. Cluster analysis revealed four distinct psychological subtypes, with the most at-risk group consisting predominantly of younger women with elevated BMI, extreme schema endorsement, and poor emotion regulation. These findings emphasize the centrality of cognitive-emotional mechanisms in eating behavior across diverse groups and suggest the importance of developing tailored, schema-informed interventions. Identifying high-risk psychological profiles may enhance the effectiveness of prevention and treatment efforts targeting disordered eating and obesity in both clinical and public health settings. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - Obara-Golebiowska, Malgorzata AU - Obara-Golebiowska M AD - Department of Clinical, Developmental and Educational Psychology, Faculty of Social Sciences, University of Warmia and Mazury in Olsztyn, Ul. Dybowskiego 13, 10-723, Olsztyn, Poland. Electronic address: m.obara-golebiowska@uwm.edu.pl. LA - eng PT - Journal Article DEP - 20250723 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - Adult MH - Male MH - *Body Mass Index MH - Middle Aged MH - *Emotional Regulation MH - *Feeding Behavior/psychology MH - Young Adult MH - Adolescent MH - Aged MH - Sex Factors MH - Age Factors MH - Obesity/psychology MH - *Feeding and Eating Disorders/psychology MH - Surveys and Questionnaires MH - Overweight/psychology MH - Hyperphagia/psychology MH - Emotions MH - Self-Control COIS- Declaration of competing interest The author declares that there are no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/07/28 08:44 MHDA- 2025/09/08 00:32 CRDT- 2025/07/25 19:36 PHST- 2025/05/22 00:00 [received] PHST- 2025/07/08 00:00 [revised] PHST- 2025/07/22 00:00 [accepted] PHST- 2025/09/08 00:32 [medline] PHST- 2025/07/28 08:44 [pubmed] PHST- 2025/07/25 19:36 [entrez] AID - S0195-6663(25)00396-4 [pii] AID - 10.1016/j.appet.2025.108243 [doi] PST - ppublish SO - Appetite. 2025 Nov 1;215:108243. doi: 10.1016/j.appet.2025.108243. Epub 2025 Jul 23. PMID- 40712555 OWN - NLM STAT- MEDLINE DCOM- 20251121 LR - 20251216 IS - 0965-206X (Print) IS - 0965-206X (Linking) VI - 34 IP - 4 DP - 2025 Nov TI - Development of a predictive formula for arterial complete occlusion pressure in upper and lower limbs during blood flow restriction. PG - 100946 LID - S0965-206X(25)00094-4 [pii] LID - 10.1016/j.jtv.2025.100946 [doi] AB - Blood flow restriction (BFR) is an innovative technique widely utilized in sports and rehabilitation for enhancing muscle strength and hypertrophy with low-load exercises. A critical factor for its efficacy and safety is determining the appropriate limb occlusion pressure (LOP). This study aimed to develop predictive formulas for estimating LOP in the upper and lower limbs based on anthropometric and hemodynamic variables, enabling a standardized and personalized approach to BFR application. A cross-sectional observational study was conducted with 39 healthy participants aged 18-40 years. Variables such as systolic and diastolic blood pressure, limb circumferences, and BMI were analyzed. LOP was measured by two independent raters using Doppler ultrasound, and multiple linear regression models were developed for each limb. Results showed that systolic blood pressure and limb circumferences were key predictors for LOP in both upper and lower limbs, explaining 39.5 % and 40.9 % of the variance, respectively. BMI was not a significant predictor in either model. High intra- and inter-rater reliability of LOP measurements was demonstrated, with intraclass correlation coefficients (ICC) of 0.99 for intra-rater and 0.98 for inter-rater reliability, indicating excellent agreement. The standard error of measurement (SEM), ranged from 1.08 to 4.10 mmHg across measures, while the minimum detectable change (MDC), ranged from 2.99 to 11.37 mmHg. The findings provide a reliable framework for personalizing BFR protocols, improving safety and efficacy while reducing variability in clinical and sports settings. Future research should validate these formulas in diverse populations and explore their application during exercise. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Garcia-Arrabe, Maria AU - Garcia-Arrabe M AD - Department of Physiotherapy, Faculty of Sports Sciences, Universidad Europea de Madrid, 28670, Madrid, Spain. FAU - Gonzalez-de-la-Flor, Angel AU - Gonzalez-de-la-Flor A AD - Department of Physiotherapy, Faculty of Sports Sciences, Universidad Europea de Madrid, 28670, Madrid, Spain. FAU - Salniccia, Federico AU - Salniccia F AD - Department of Physiotherapy, Faculty of Sports Sciences, Universidad Europea de Madrid, 28670, Madrid, Spain. FAU - Lopez-Ruiz, Javier AU - Lopez-Ruiz J AD - Department of Physiotherapy, Faculty of Sports Sciences, Universidad Europea de Madrid, 28670, Madrid, Spain. Electronic address: javier.lopez3@universidadeuropea.es. FAU - Garcia-Perez-de-Sevilla, Guillermo AU - Garcia-Perez-de-Sevilla G AD - Department of Physiotherapy, Faculty of Sports Sciences, Universidad Europea de Madrid, 28670, Madrid, Spain. LA - eng PT - Journal Article PT - Observational Study DEP - 20250722 PL - England TA - J Tissue Viability JT - Journal of tissue viability JID - 9306822 SB - IM MH - Humans MH - Male MH - Adult MH - Female MH - Cross-Sectional Studies MH - *Lower Extremity/blood supply/physiopathology MH - Adolescent MH - *Upper Extremity/blood supply/physiopathology MH - *Blood Flow Restriction Therapy/methods/standards MH - Young Adult MH - Reproducibility of Results OTO - NOTNLM OT - Anthropometric variables OT - Blood flow restriction OT - Doppler ultrasound OT - Intraclass correlation coefficient OT - Limb occlusion pressure OT - Minimum detectable change OT - Predictive formula OT - Sports rehabilitation OT - Standard error of measurement COIS- Conflict of interest statement The authors of the manuscript entitled "Development of a Predictive Formula for Arterial Complete Occlusion Pressure in Upper and Lower Limbs During Blood Flow Restriction" declare no conflicts of interest regarding its publication. The study was conducted independently, and no financial or personal relationships influenced the design, data collection, analysis, or reporting of this research. The authors Maria Garcia-Arrabe, Angel Gonzalez-de-la-Flor, Federico Salniccia, Javier Lopez-Ruiz and Guillermo Garcia-Perez-de-Sevilla have reviewed and approved the final version of the manuscript and confirm its submission to the Journal of Tissue Viability. EDAT- 2025/07/28 08:44 MHDA- 2025/11/22 00:28 CRDT- 2025/07/25 18:11 PHST- 2024/12/13 00:00 [received] PHST- 2025/06/05 00:00 [revised] PHST- 2025/07/22 00:00 [accepted] PHST- 2025/11/22 00:28 [medline] PHST- 2025/07/28 08:44 [pubmed] PHST- 2025/07/25 18:11 [entrez] AID - S0965-206X(25)00094-4 [pii] AID - 10.1016/j.jtv.2025.100946 [doi] PST - ppublish SO - J Tissue Viability. 2025 Nov;34(4):100946. doi: 10.1016/j.jtv.2025.100946. Epub 2025 Jul 22. PMID- 40709676 OWN - NLM STAT- MEDLINE DCOM- 20250725 LR - 20250802 IS - 1976-2437 (Electronic) IS - 0513-5796 (Print) IS - 0513-5796 (Linking) VI - 66 IP - 8 DP - 2025 Aug TI - Prediction Model for Insulin Resistance and Implications for MASLD in Youth: A Novel Marker, the Pediatric Insulin Resistance Assessment Score. PG - 464-472 LID - 10.3349/ymj.2024.0442 [doi] AB - PURPOSE: Insulin resistance (IR) is a condition closely associated with cardiovascular risk factors and metabolic dysfunction-associated steatotic liver disease (MASLD) is emerging as a significant IR-related complication. We aimed to develop a predictive model for IR in youths and implicate this model for MASLD. MATERIALS AND METHODS: A total of 1588 youths from the population-based data were included in the training set. For the test sets, 121 participants were included for IR and 50 for MASLD from real-world clinic data. Logistic regression analysis, random forest, extreme gradient boosting (XGBoost), light gradient boosting machine (GBM), and deep neural network (DNN) were used to develop the models. A nomogram scoring system was constructed based on a model used to predict the probability of IR and MASLD. RESULTS: After stepwise selection, age, body mass index (BMI) standard deviation score (SDS), waist circumference (WC), systolic blood pressure, HbA1c, high-density lipoprotein cholesterol, triglyceride, and alanine aminotransferase levels were included in the model. A nomogram scoring system was constructed based on a multivariable logistic regression model. The areas under the curves (AUCs) of the models for IR prediction in external validation were 0.75 (logistic regression), 0.78 (random forest), 0.72 (XGBoost), 0.71 (light GBM), and 0.71 (DNN). For MASLD prediction, the AUCs were 0.93 (logistic regression), 0.95 (random forest), 0.90 (XGBoost), 0.91 (light GBM), and 0.85 (DNN). BMI SDS and WC SDS were the most important contributors to IR prediction in all models. CONCLUSION: The Pediatric Insulin Resistance Assessment Score is a novel scoring system for predicting IR and MASLD in youths. CI - (c) Copyright: Yonsei University College of Medicine 2025. FAU - Song, Kyungchul AU - Song K AUID- ORCID: 0000-0002-8497-5934 AD - Department of Pediatrics, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. FAU - Lee, Eunju AU - Lee E AUID- ORCID: 0009-0003-7271-8310 AD - Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea. FAU - Youn, Young Hoon AU - Youn YH AUID- ORCID: 0000-0002-0071-229X AD - Department of Healthcare Research Team, Health Promotion Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. FAU - Baik, Su Jung AU - Baik SJ AUID- ORCID: 0000-0002-3790-7701 AD - Department of Healthcare Research Team, Health Promotion Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. FAU - Shin, Hyun Joo AU - Shin HJ AUID- ORCID: 0000-0002-7462-2609 AD - Department of Radiology, Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea. FAU - Lee, Ji-Won AU - Lee JW AUID- ORCID: 0000-0002-2666-4249 AD - Department of Family Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. AD - Institute for Innovation in Digital Healthcare, Yonsei University, Seoul, Korea. FAU - Chae, Hyun Wook AU - Chae HW AUID- ORCID: 0000-0001-5016-8539 AD - Department of Pediatrics, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. FAU - Lee, Hye Sun AU - Lee HS AUID- ORCID: 0000-0001-6328-6948 AD - Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea. hslee1@yuhs.ac. FAU - Kwon, Yu-Jin AU - Kwon YJ AUID- ORCID: 0000-0002-9021-3856 AD - Department of Family Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea. digda3@yuhs.ac. LA - eng GR - 20018384/MOTIE/Ministry of Trade, Industry & Energy/Korea PT - Journal Article PL - Korea (South) TA - Yonsei Med J JT - Yonsei medical journal JID - 0414003 RN - 0 (Biomarkers) RN - EC 2.6.1.2 (Alanine Transaminase) SB - IM MH - Humans MH - *Insulin Resistance/physiology MH - Male MH - Female MH - Adolescent MH - Child MH - Body Mass Index MH - Logistic Models MH - Waist Circumference MH - *Fatty Liver/metabolism/diagnosis MH - Biomarkers MH - Nomograms MH - Risk Factors MH - Alanine Transaminase/blood PMC - PMC12303674 OTO - NOTNLM OT - Insulin resistance OT - adolescent OT - child OT - machine learning OT - metabolic dysfunction-associated steatotic liver disease COIS- The authors have no potential conflicts of interest to disclose. EDAT- 2025/07/25 12:31 MHDA- 2025/07/25 12:32 PMCR- 2025/08/01 CRDT- 2025/07/25 07:03 PHST- 2024/12/23 00:00 [received] PHST- 2025/01/31 00:00 [revised] PHST- 2025/02/19 00:00 [accepted] PHST- 2025/07/25 12:32 [medline] PHST- 2025/07/25 12:31 [pubmed] PHST- 2025/07/25 07:03 [entrez] PHST- 2025/08/01 00:00 [pmc-release] AID - 66.464 [pii] AID - 10.3349/ymj.2024.0442 [doi] PST - ppublish SO - Yonsei Med J. 2025 Aug;66(8):464-472. doi: 10.3349/ymj.2024.0442. PMID- 40709153 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250729 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 17 IP - 6 DP - 2025 Jun TI - Prevalence and Characteristics of Eating Behavior Disorders Among Children and Adolescents. PG - e86586 LID - 10.7759/cureus.86586 [doi] LID - e86586 AB - This descriptive cross-sectional study was conducted between January and March 2024 at the University Hospital in Oujda and several educational institutions, involving a randomly selected sample of children and adolescents aged 7-18 years. The University Hospital Center of Oujda and the selected educational institutions were chosen for their accessibility and their capacity to represent a broad spectrum of children and adolescents from various socioeconomic backgrounds within Oujda and neighboring areas. This allowed for the recruitment of a diverse and representative sample reflective of the local population. The objective was to assess the prevalence of eating behavior disorders - namely, anorexia nervosa, bulimia nervosa, and avoidant/restrictive food intake disorder (ARFID) - and to identify potential risk factors. Data were collected using structured questionnaires and two validated screening tools: the Eating Behavior Disorders in Youth Questionnaire (EDY-Q) and the Eating Attitudes Test (EAT-26). The mean age of participants was 14 years, with the 13-17 age group being the most affected, and the majority were female. Psychological vulnerabilities related to eating disorders were observed. Significant associations were found between susceptibility to eating disorders and factors such as older age, female gender, exposure to major family stressors, excessive media use, and academic pressure. However, socioeconomic status did not show a significant correlation. These findings suggest a notable prevalence of eating disorders among adolescents, emphasizing the urgent need for early prevention strategies and health promotion programs to mitigate long-term mental and physical health consequences. CI - Copyright (c) 2025, Erraoui et al. FAU - Erraoui, Islam AU - Erraoui I AD - Pediatrics, University Hospital Center (CHU) Mohammed VI, Oujda, MAR. FAU - Hamami, Amal AU - Hamami A AD - Pediatrics, University Hospital Center (CHU) Mohammed VI, Oujda, MAR. FAU - Elouali, Aziza AU - Elouali A AD - Pediatrics, Faculty of Medicine and Pharmacy, Mohammed I University, Oujda, MAR. FAU - Abdeladim, Babakhouya AU - Abdeladim B AD - Pediatrics, University Hospital Center (CHU) Mohammed VI, Oujda, MAR. FAU - Rkain, Maria AU - Rkain M AD - Faculty of Medicine and Pharmacy, Mohammed I University, Oujda, MAR. AD - Pediatrics, University Hospital Center (CHU) Mohammed VI, Oujda, MAR. AD - Pediatric Gastroenterology, University Hospital Center (CHU) Mohammed VI, Oujda, MAR. LA - eng PT - Journal Article DEP - 20250623 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC12287424 OTO - NOTNLM OT - anorexia nervosa OT - bulimia nervosa OT - children and adolescents OT - eating disorders OT - risk factors OT - social media COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. CERBO issued approval 1. In accordance with the strictly observational nature of this study, the ethics committee has reviewed the protocol and concluded that formal approval is not required. No interventions are performed on participants, and only pre-existing, non-sensitive clinical data are used. Therefore, this research is classified as non-interventional and does not require prior ethical approval. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2025/07/25 06:38 MHDA- 2025/07/25 06:39 PMCR- 2025/06/23 CRDT- 2025/07/25 04:32 PHST- 2025/06/22 00:00 [accepted] PHST- 2025/07/25 06:39 [medline] PHST- 2025/07/25 06:38 [pubmed] PHST- 2025/07/25 04:32 [entrez] PHST- 2025/06/23 00:00 [pmc-release] AID - 10.7759/cureus.86586 [doi] PST - epublish SO - Cureus. 2025 Jun 23;17(6):e86586. doi: 10.7759/cureus.86586. eCollection 2025 Jun. PMID- 40707056 OWN - NLM STAT- MEDLINE DCOM- 20260121 LR - 20260511 IS - 1529-4242 (Electronic) IS - 0032-1052 (Linking) VI - 157 IP - 2 DP - 2026 Feb 1 TI - Anthropometrics versus Experts' Subjective Analysis of Cleft Severity and PSIO Outcomes in Unilateral Clefts: A New Grading System. PG - 242e-252e LID - 10.1097/PRS.0000000000012323 [doi] AB - BACKGROUND: The severity of unilateral cleft lip significantly influences surgical outcomes, yet no standardized system exists to classify cleft severity or assess the impact of presurgical infant orthopedics (PSIO). This study proposes an objective classification system, integrating anthropometric measurements with expert evaluations. METHODS: Deidentified pre-PSIO and post-PSIO photographs of 50 infants with unilateral cleft lip from the Smile Train Express database were analyzed. Three anthropometric parameters-nostril width ratio (NWR), columellar angle (CA), and subnasale lateral displacement (SN)-were measured. An expert panel of orthodontists and surgeons independently rated cleft severity and PSIO outcomes, in a structured 3-stage process. Severity thresholds were established through consensus, and interrater agreement was analyzed using weighted kappa. RESULTS: Consensus-derived thresholds categorized NWR, CA, and SN into 4 severity levels. Interrater agreement for cleft severity improved across stages, reaching nearly perfect levels in stage 3 (pre-PSIO weighted kappa, 0.91; post-PSIO weighted kappa, 0.93). Although pre-PSIO agreement was similar between surgeons and orthodontists, post-PSIO assessments showed greater variability. PSIO had a disproportionate effect on nasal morphology (CA) compared with maxillary segments (NWR and SN), with severe NWR and SN frequently coexisting with mild CA. The proposed classification system demonstrated substantial reliability, aligning at least 2 parameters within the same severity subclassification. CONCLUSIONS: This study introduces a standardized classification system for cleft severity and PSIO outcomes, demonstrating strong interrater reliability. By integrating anthropometric data with expert assessments, it provides a reproducible framework for clinical and research applications. Further refinements, including intraoral measurements and 3-dimensional imaging, may enhance its precision and applicability. CI - Copyright (c) 2025 by the American Society of Plastic Surgeons. FAU - Tanikawa, Daniela Y S AU - Tanikawa DYS AD - From the Cleft Lip and Palate Team, Menino Jesus Municipal Hospital; Cleft Lip and Palate Center, Sabara Children's Hospital. FAU - Chong, David K AU - Chong DK AD - Department of Plastic and Maxillofacial Surgery, Royal Children's Hospital. FAU - Fisher, David M AU - Fisher DM AD - Division of Plastic Surgery, The Hospital for Sick Children, and Department of Surgery, University of Toronto. FAU - Alonso, Nivaldo AU - Alonso N AD - Department of Plastic and Reconstructive Surgery, University of Sao Paulo School of Medicine. FAU - Shetye, Pradip R AU - Shetye PR AD - Hansjorg Wyss Department of Plastic Surgery, New York University Grossman School of Medicine, New York University College of Dentistry. FAU - Batra, Puneet AU - Batra P AD - Department of Orthodontics and Dentofacial Orthopedics, Manav Rachna Dental College, Manav Rachna Institute of Research and Studies. FAU - Flores, Robert L AU - Flores RL AD - Hansjorg Wyss Department of Plastic Surgery, New York University Langone Health. FAU - Figueroa, Alvaro A AU - Figueroa AA AD - Figueroa Orthodontics. LA - eng PT - Comparative Study PT - Journal Article DEP - 20250721 PL - United States TA - Plast Reconstr Surg JT - Plastic and reconstructive surgery JID - 1306050 SB - IM MH - Humans MH - *Cleft Lip/surgery/classification/diagnosis/pathology MH - Severity of Illness Index MH - Female MH - Infant MH - Male MH - *Anthropometry/methods MH - Treatment Outcome MH - Observer Variation MH - Preoperative Care/methods MH - Retrospective Studies EDAT- 2025/07/25 00:29 MHDA- 2026/01/21 12:58 CRDT- 2025/07/24 20:52 PHST- 2026/01/21 12:58 [medline] PHST- 2025/07/25 00:29 [pubmed] PHST- 2025/07/24 20:52 [entrez] AID - 00006534-990000000-02710 [pii] AID - 10.1097/PRS.0000000000012323 [doi] PST - ppublish SO - Plast Reconstr Surg. 2026 Feb 1;157(2):242e-252e. doi: 10.1097/PRS.0000000000012323. Epub 2025 Jul 21. PMID- 40706277 OWN - NLM STAT- MEDLINE DCOM- 20250826 LR - 20260904 IS - 1872-7123 (Electronic) IS - 0165-1781 (Linking) VI - 351 DP - 2025 Sep TI - Validated eating disorder screening tools for paediatric populations: A systematic review. PG - 116631 LID - S0165-1781(25)00279-3 [pii] LID - 10.1016/j.psychres.2025.116631 [doi] AB - IMPORTANCE: The COVID-19 pandemic has led to a rise in paediatric eating disorder (ED) cases, highlighting the need for validated screening tools, particularly for pre-adolescent children, to enable early detection. OBJECTIVE: This review aims to systematically evaluate the validation and psychometric properties of screening tools for assessing EDs in the paediatric population, with a focus on pre-adolescents (under 12 years). EVIDENCE REVIEW: A systematic search of Medline (OVID) and PsycInfo (OVID) databases was conducted following Cochrane Rapid Review Guidelines, registered with PROSPERO (CRD42023465366). Studies were selected based on seven criteria, including ED diagnoses (anorexia nervosa, avoidant/restrictive food intake disorder, bulimia nervosa, binge eating disorder) in children under 12. A random 20% sample was cross-checked for errors. Data extraction followed a pre-defined template with additional independent checks. The primary outcome was the predictive validity of the screening tools. RESULTS: Of 3,911 citations screened, 28 studies (N=25,444) were included, with six focusing on children under 12 (N=1,430). The methods varied, with 18 studies using clinical interviews and 10 using validated questionnaires. Most tools achieved a Level 3 rating on The Rational Clinical Examination Levels of Evidence, indicating methodological limitations. The child version of the Eating Attitudes Test (ChEAT) had the most evidence, though it has not been validated for DSM-5 criteria. CONCLUSIONS AND RELEVANCE: There is a significant gap in validated ED screening tools for children under 12. Future research should focus on developing tools for this population to improve early detection and treatment outcomes. CI - Copyright (c) 2025. Published by Elsevier B.V. FAU - Jabs, Maya AU - Jabs M AD - Flinders University Institute for Mental Health and Wellbeing, South Australia, Australia. FAU - Pennesi, Jamie-Lee AU - Pennesi JL AD - Flinders University Institute for Mental Health and Wellbeing, South Australia, Australia. FAU - Baillie, Simone AU - Baillie S AD - Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia. FAU - Hay, Phillipa AU - Hay P AD - Western Sydney University, New South Wales, Australia. FAU - Mitchison, Deborah AU - Mitchison D AD - University of Technology Sydney, New South Wales, Australia. FAU - Norton, Lyza AU - Norton L AD - Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia; Western Sydney University, New South Wales, Australia. FAU - Prnjak, Katarina AU - Prnjak K AD - Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia; Western Sydney University, New South Wales, Australia. FAU - Wade, Tracey D AU - Wade TD AD - Flinders University Institute for Mental Health and Wellbeing, South Australia, Australia. FAU - Hart, Laura AU - Hart L AD - Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia. Electronic address: lhart@unimelb.edu.au. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Systematic Review DEP - 20250705 PL - Ireland TA - Psychiatry Res JT - Psychiatry research JID - 7911385 SB - IM MH - Humans MH - Child MH - *Psychometrics MH - *Feeding and Eating Disorders/diagnosis MH - *Mass Screening MH - Child, Preschool MH - Reproducibility of Results MH - *Psychiatric Status Rating Scales/standards OTO - NOTNLM OT - Assessment OT - Early detection Screening OT - Eating Disorders OT - Paediatrics OT - Psychometrics OT - Validation COIS- Declaration of competing interest The authors declare no conflict of interest. The funding source was not involved in the design, data collection, analysis, interpretation of data, or writing of the manuscript. EDAT- 2025/07/25 00:28 MHDA- 2025/09/08 08:05 CRDT- 2025/07/24 18:06 PHST- 2025/02/26 00:00 [received] PHST- 2025/07/03 00:00 [revised] PHST- 2025/07/04 00:00 [accepted] PHST- 2025/09/08 08:05 [medline] PHST- 2025/07/25 00:28 [pubmed] PHST- 2025/07/24 18:06 [entrez] AID - S0165-1781(25)00279-3 [pii] AID - 10.1016/j.psychres.2025.116631 [doi] PST - ppublish SO - Psychiatry Res. 2025 Sep;351:116631. doi: 10.1016/j.psychres.2025.116631. Epub 2025 Jul 5. PMID- 40706081 OWN - NLM STAT- MEDLINE DCOM- 20250724 LR - 20260619 IS - 2564-1891 (Electronic) IS - 2564-1891 (Linking) VI - 5 DP - 2025 Jul 24 TI - Harnessing Facebook to Investigate Real-World Mentions of Adverse Events of Glucagon-Like Peptide-1 Receptor Agonist (GLP-1 RA) Medications: Observational Study of Facebook Posts From 2022 to 2024. PG - e73619 LID - 10.2196/73619 [doi] LID - e73619 AB - BACKGROUND: In recent years, there has been a dramatic increase in the popularity and use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for weight loss. As such, it is essential to understand users' real-world discussions of short-term, long-term, and co-occurrent adverse events associated with currently used GLP-1 RA medications. OBJECTIVE: This study aims to quantitatively analyze temporal and co-occurrent GLP-1 RA adverse event trends through discussions of GLP-1 RA weight loss medications on Facebook from 2022 to 2024. METHODS: We collected 64,202 Facebook posts (59,293 posts after removing duplicate posts) from January 1, 2022, to May 31, 2024, through CrowdTangle, a public insights tool from Meta. Using English language social media posts from the United States, we examined discussions of adverse event mentions for posts referencing 7 GLP-1 RA weight loss product categories (ie, semaglutide, Ozempic, Wegovy, tirzepatide, Mounjaro, Zepbound, and GLP-1 RA as a class). All analyses were conducted using Python (version 3; Python Software Foundation) in a Google Colab environment. RESULTS: Temporal time series analysis revealed that the GLP-1 RAs' adverse event mentions on social media aligned with several key events: the Food and Drug Administration's approval of Wegovy for pediatric weight management in December 2022, increased media coverage in August 2023, celebrity endorsement in December 2023, and Medicare Part D coverage expansion for weight loss medications in March 2024. Gastrointestinal (GI)-related adverse events (general term) were most prevalent for posts mentioning the GLP-1 RA class (210/4885, 4.30%) and Mounjaro (241/4031, 5.98%). In contrast, the most prevalent adverse event mentions noted for tirzepatide were headache (78/4202, 1.86%) and joint pain (71/4202, 1.69%). Hypertension (13/1769, 0.73%) was frequently mentioned in Zepbound posts, while pancreatitis was commonly associated with Mounjaro posts (44/4031, 1.08%), and 2.85% (139/4885) of posts broadly referring to the GLP-1 RA class. Furthermore, an integrated node network analysis revealed 3 distinct GLP-1 RA adverse events-mentioned clusters: cluster 1 (purple) contained allergies, anxiety, depression, chronic obstructive pulmonary disease, fatigue, fever, hypertension, indigestion, insomnia, gastroesophageal reflux disease, hives, swelling, restlessness, and seizures. Cluster 2 (pink) contained constipation, dehydration, headache, diarrhea, dizziness, hypoglycemia, sweating, and jaundice. Cluster 3 (brown) contained GI symptoms, such as nausea, pancreatitis, rash, and vomiting. The GI symptoms, such as nausea, vomiting, pancreatitis, diarrhea, and indigestion, were strongly associated together (>/=100 co-occurrence mentions), while the mentioned neurological symptoms, such as anxiety, depression, and insomnia, were highly correlated with each other (50-100 co-occurrence mentions). CONCLUSIONS: This social media study highlights the adverse event mention patterns for posts referencing GLP-1 RA medications. While further research is needed to rigorously examine and validate these findings, this study demonstrates the importance of monitoring social media discussions to predict novel, underreported, or rare drug adverse events, thereby improving patient care, clinical research, and health policy interventions. CI - (c) Amrutha S Alibilli, Vidur Jain, Heran Mane, Xiaohe Yue, Alexandria Ratzki-Leewing, Junaid S Merchant, Shaniece Criss, Quynh C Nguyen, Rozalina G McCoy, Thu T Nguyen. Originally published in JMIR Infodemiology (https://infodemiology.jmir.org). FAU - Alibilli, Amrutha S AU - Alibilli AS AUID- ORCID: 0009-0006-3932-264X AD - Department of Epidemiology and Biostatistics, University of Maryland, College Park, 4254 Stadium Drive, College Park, 20742, United States, 1 301-405-6589. FAU - Jain, Vidur AU - Jain V AUID- ORCID: 0009-0000-9454-0515 AD - Department of Epidemiology and Biostatistics, University of Maryland, College Park, 4254 Stadium Drive, College Park, 20742, United States, 1 301-405-6589. FAU - Mane, Heran AU - Mane H AUID- ORCID: 0000-0001-8859-3282 AD - Department of Epidemiology and Biostatistics, University of Maryland, College Park, 4254 Stadium Drive, College Park, 20742, United States, 1 301-405-6589. FAU - Yue, Xiaohe AU - Yue X AUID- ORCID: 0000-0001-5922-1949 AD - Department of Epidemiology and Biostatistics, University of Maryland, College Park, 4254 Stadium Drive, College Park, 20742, United States, 1 301-405-6589. FAU - Ratzki-Leewing, Alexandria AU - Ratzki-Leewing A AUID- ORCID: 0000-0002-9474-7900 AD - Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, United States. AD - University of Maryland Institute for Health Computing, North Bethesda, MD, United States. FAU - Merchant, Junaid S AU - Merchant JS AUID- ORCID: 0000-0002-4315-6211 AD - Department of Epidemiology and Biostatistics, University of Maryland, College Park, 4254 Stadium Drive, College Park, 20742, United States, 1 301-405-6589. FAU - Criss, Shaniece AU - Criss S AUID- ORCID: 0000-0002-2470-5377 AD - Department of Health Sciences, Furman University, Greenville, SC, United States. FAU - Nguyen, Quynh C AU - Nguyen QC AUID- ORCID: 0009-0006-1184-1560 AD - National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, United States. FAU - McCoy, Rozalina G AU - McCoy RG AUID- ORCID: 0000-0002-2289-3183 AD - Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, United States. AD - University of Maryland Institute for Health Computing, North Bethesda, MD, United States. AD - Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States. FAU - Nguyen, Thu T AU - Nguyen TT AUID- ORCID: 0000-0003-1185-045X AD - Department of Epidemiology and Biostatistics, University of Maryland, College Park, 4254 Stadium Drive, College Park, 20742, United States, 1 301-405-6589. AD - University of Maryland Institute for Health Computing, North Bethesda, MD, United States. LA - eng GR - R01 MD015716/MD/NIMHD NIH HHS/United States GR - INTRAMURAL RESEARCH PROGRAM/National Institutes of Health./ PT - Journal Article PT - Observational Study PT - Research Support, N.I.H., Intramural DEP - 20250724 PL - Canada TA - JMIR Infodemiology JT - JMIR infodemiology JID - 9918249014806676 RN - 0 (Glucagon-Like Peptide-1 Receptor Agonists) RN - 0 (Hypoglycemic Agents) RN - 62340-29-8 (Glucagon-Like Peptides) RN - 89750-14-1 (Glucagon-Like Peptide 1) RN - 53AXN4NNHX (Semaglutide) SB - IM MH - Humans MH - *Social Media/statistics & numerical data MH - *Glucagon-Like Peptide-1 Receptor Agonists MH - United States MH - *Hypoglycemic Agents/adverse effects MH - *Drug-Related Side Effects and Adverse Reactions/epidemiology MH - Glucagon-Like Peptides/adverse effects MH - Glucagon-Like Peptide 1 MH - Semaglutide PMC - PMC12289294 OTO - NOTNLM OT - GLP-1 RAs OT - Mounjaro OT - Ozempic OT - Wegovy OT - Zepbound OT - adverse events OT - obesity management OT - semaglutide OT - social media OT - tirzepatide OT - weight loss medication COIS- Conflicts of Interest: TTN is a member of the JMIR Infodemiology Editorial Board. All other authors declare no conflicts of interest. EDAT- 2025/07/24 18:30 MHDA- 2025/07/24 18:31 PMCR- 2025/07/24 CRDT- 2025/07/24 17:23 PHST- 2025/03/08 00:00 [received] PHST- 2025/05/22 00:00 [revised] PHST- 2025/05/27 00:00 [accepted] PHST- 2025/07/24 18:31 [medline] PHST- 2025/07/24 18:30 [pubmed] PHST- 2025/07/24 17:23 [entrez] PHST- 2025/07/24 00:00 [pmc-release] AID - v5i1e73619 [pii] AID - 73619 [pii] AID - 10.2196/73619 [doi] PST - epublish SO - JMIR Infodemiology. 2025 Jul 24;5:e73619. doi: 10.2196/73619. PMID- 40705226 OWN - NLM STAT- MEDLINE DCOM- 20250827 LR - 20260530 IS - 1867-0687 (Electronic) VI - 21 IP - 8 DP - 2025 Aug TI - Potential diagnostic value of serum bile acid profiling in girls with central precocious puberty. PG - 811-822 LID - 10.1007/s12519-025-00937-z [doi] AB - BACKGROUND: The diagnosis of central precocious puberty (CPP) relies on a gonadotropin releasing hormone stimulation test to assess the activation of the hypothalamic-pituitary-gonadal axis; this is costly and painful. Bile acids (BAs) have emerged as pivotal signaling molecules in the reproductive system. This study aimed to identify circulating BA profile signatures and explored if they may serve as biomarkers for CPP diagnosis in girls. METHODS: We enrolled 431 girls, including 241 in the training cohort and 190 in the validation cohort. Participants were divided into four groups based on their body mass index Z-score and whether they were diagnosed with CPP. Ultra-performance liquid chromatography coupled with tandem mass spectrometry was performed to quantify 38 serum BAs. RESULTS: There were 18 individual BAs that were statistically different between CPP and non-CPP counterparts. The majority of these BAs (14/18) correlated significantly with sex-related hormones (P < 0.05). In girls with normal weight (NW), a logistic regression model combining chenodeoxycholic acid, tauroalpha-muricholic acid, and 6-ketolithocholic acid achieved an area under the receiver operating characteristic curve (AUC) of 0.885. For girls who were overweight/obese (OB), hyocholic acid and taurohyocholic acid enhanced the diagnostic efficiency of basal luteinizing and follicle stimulating hormones to an AUC value 0.914. In validation cohort, 75.34% NW girls and 84.09% OB girls were accurately classified. CONCLUSIONS: Serum BA profiles of CPP girls showed significant changes that were associated with serum sex-related hormone levels. BA profiles could be potential biomarkers in CPP diagnosis and screening. Video Abstract. CI - (c) 2025. Children's Hospital, Zhejiang University School of Medicine. FAU - Wang, Shan AU - Wang S AD - Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China. FAU - Liu, A Na AU - Liu AN AD - Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China. FAU - Liang, Xin-Yi AU - Liang XY AD - Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China. FAU - Jiang, Ling AU - Jiang L AD - Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China. FAU - Wu, Wei AU - Wu W AD - Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China. FAU - Dong, Guan-Ping AU - Dong GP AD - Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China. FAU - Jiang, Pei-Fang AU - Jiang PF AD - Department of Neurology, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China. FAU - Ni, Yan AU - Ni Y AUID- ORCID: 0000-0003-1779-7266 AD - Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China. yanni617@zju.edu.cn. FAU - Fu, Jun-Fen AU - Fu JF AUID- ORCID: 0000-0001-6405-1251 AD - Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China. fjf68@zju.edu.cn. LA - eng GR - 2021YFC2701900/National Key Research and Development Program of China/ GR - 82170583/National Natural Science Foundation of China/ GR - 82370863/National Natural Science Foundation of China/ GR - 2023C03047/Key Research and Development Program of Zhejiang/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250724 PL - Switzerland TA - World J Pediatr JT - World journal of pediatrics : WJP JID - 101278599 RN - 0 (Bile Acids and Salts) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Puberty, Precocious/diagnosis/blood MH - Female MH - Child MH - *Bile Acids and Salts/blood MH - Biomarkers/blood MH - ROC Curve MH - Cohort Studies OTO - NOTNLM OT - Bile acid OT - Central precocious puberty OT - Diagnosis OT - Serum biomarkers OT - Targeted metabolomics COIS- Declarations. Ethical approval: The study was approved by the Medical Ethics Committee of the Children's Hospital, Zhejiang University School of Medicine (2021-IRB-038) and registered in the Chinese Clinical Trial Registry (ChiCTR2100045616). Detailed explanations of the study were conveyed to each subject and their parents and informed consent to participate in the study have been obtained from their parent or legal guardian. Conflict of interest: No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article. Author Jun-Fen Fu is a member of the Editorial Board for World Journal of Pediatrics. The paper was handled by the other Editor and has undergone rigorous peer review process. Author Jun-Fen Fu was not involved in the journal's review of or decisions related to this manuscript. The authors have no conflict of interest to declare. EDAT- 2025/07/24 12:29 MHDA- 2025/09/08 08:05 CRDT- 2025/07/24 11:19 PHST- 2025/03/25 00:00 [received] PHST- 2025/06/05 00:00 [accepted] PHST- 2025/06/04 00:00 [revised] PHST- 2025/09/08 08:05 [medline] PHST- 2025/07/24 12:29 [pubmed] PHST- 2025/07/24 11:19 [entrez] AID - 10.1007/s12519-025-00937-z [pii] AID - 10.1007/s12519-025-00937-z [doi] PST - ppublish SO - World J Pediatr. 2025 Aug;21(8):811-822. doi: 10.1007/s12519-025-00937-z. Epub 2025 Jul 24. PMID- 40705083 OWN - NLM STAT- MEDLINE DCOM- 20250724 LR - 20261010 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 184 IP - 8 DP - 2025 Jul 24 TI - Is greater adherence to the Mediterranean diet related to higher health-related quality of life among children and adolescents? A systematic review and meta-analysis. PG - 498 LID - 10.1007/s00431-025-06298-z [doi] AB - Adherence to the Mediterranean diet (MedDiet) has been linked to better physical and mental health outcomes. However, its relationship with health-related quality of life (HRQoL) in children and adolescents has not been quantitatively assessed. To examine the association between adherence to the MedDiet and HRQoL in children and adolescents through a systematic review and meta-analysis of observational studies. PubMed, Scopus, Web of Science, and Cochrane Library were searched from inception through November 1, 2024. Observational studies assessing the association between MedDiet adherence and HRQoL in participants aged 2 years and 11 patients were initiated on TKI during the study. Anthropometric measurements, Tanner staging, and laboratory parameters assessing endocrine function, bone health, glucose and lipid metabolism were evaluated. QoL was assessed with validated instruments. RESULTS: Median duration of TKI exposure was 7.5 years. Short stature was observed in 15% (11/71) of patients. Among those who were prepubertal at TKI initiation, 26.5% (9/34) were found to have short stature. Low Bone mineral density was found in 35.2% (24/68). Vitamin D deficiency was found in 84% and subclinical hypothyroidism in 9.8% (7/71). Two patients had poor sperm quality. One male patient had infertility. There was less impact on glucose, lipid profile, and adrenal function. In the QoL analysis, social functioning was affected among the functional scales, while financial difficulties, appetite loss, and fatigue were impacted in the symptom scales. Overall, QoL scores for physical, psychosocial, and school functioning remained well-preserved, but longer TKI treatment duration was associated to lower scores in these domains. DISCUSSION: This comprehensive evaluation highlights the need for close monitoring of BMD in patients who are on long-term TKI therapy. Evaluation of all other endocrine functions can be done as clinically indicated. CI - Copyright (c) 2025 Mohan, Nagpal, Upadhya, Kumar, Khadgawat, Bakhshi and Pushpam. FAU - Mohan, Rajiv AU - Mohan R AD - Department of Medical Oncology, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India. FAU - Nagpal, Chitrakshi AU - Nagpal C AD - Department of Medical Oncology, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India. FAU - Upadhya, Swasthik AU - Upadhya S AD - Department of Medical Oncology, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India. FAU - Kumar, Akash AU - Kumar A AD - Department of Medical Oncology, National Cancer Institute, All India Institute of Medical Sciences, Jhajjar, Haryana, India. FAU - Khadgawat, Rajesh AU - Khadgawat R AD - Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India. FAU - Bakhshi, Sameer AU - Bakhshi S AD - Department of Medical Oncology, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India. FAU - Pushpam, Deepam AU - Pushpam D AD - Department of Medical Oncology, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India. LA - eng PT - Journal Article DEP - 20250708 PL - Switzerland TA - Front Oncol JT - Frontiers in oncology JID - 101568867 PMC - PMC12279693 OTO - NOTNLM OT - CML OT - TKI OT - endocrine effects OT - paediatric OT - quality of life OT - young COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/07/23 11:25 MHDA- 2025/07/23 11:26 PMCR- 2025/07/08 CRDT- 2025/07/23 04:55 PHST- 2025/03/22 00:00 [received] PHST- 2025/06/19 00:00 [accepted] PHST- 2025/07/23 11:26 [medline] PHST- 2025/07/23 11:25 [pubmed] PHST- 2025/07/23 04:55 [entrez] PHST- 2025/07/08 00:00 [pmc-release] AID - 10.3389/fonc.2025.1598104 [doi] PST - epublish SO - Front Oncol. 2025 Jul 8;15:1598104. doi: 10.3389/fonc.2025.1598104. eCollection 2025. PMID- 40695407 OWN - NLM STAT- MEDLINE DCOM- 20250923 LR - 20250923 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 69 DP - 2025 Oct TI - The effect of passive and exercise-induced dehydration on body composition using dual energy X-ray absorptiometry. PG - 333-341 LID - S2405-4577(25)01759-0 [pii] LID - 10.1016/j.clnesp.2025.07.011 [doi] AB - PURPOSE: To determine the effect of dehydration on changes in body composition using dual energy x-ray absorptiometry (DXA). METHODOLOGY: Sixty college students completed a non-exercise control (NEC) and an exercise-induced dehydration (EID) session. Both sessions were held on a climatized control laboratory at 30 degrees C and a relative humidity of 70 %. Exercise was performed on a stationary bicycle for 60-min at an intensity of 65 %-75 % of the reserve heart rate. Body composition was assessed by DXA before and after the sessions and the mean body composition differences were correlated with the degree of dehydration achieved by the participants. RESULTS: The experimental sessions elicited dehydration in all the participants (NEC = 0.50 +/- 0.51 % vs. EID = 1.11 +/- 0.45 %; p PA --> resilience --> EBPs). OBJECTIVE: This study examined the chained mediating roles of physical activity and psychological resilience in the relationship between multidimensional parenting styles (emotional warmth, rejection, overprotection) and EBPs among Chinese adolescents, testing pathways informed by family systems theory and bioecological frameworks. PARTICIPANTS AND SETTING: A sample of 503 adolescents (51.09% male; SD = 1.41) was recruited through three-stage cluster sampling across Zhuhai, Guangdong, China. Participants were purposively selected from transition grades: elementary (Grades 5-6, ages 10-12) and junior high schools (Grades 7-9, ages 13-15) across 8 institutions (4 key + 4 general schools). Data collection occurred between April-December 2024, with 89.83% retention after excluding incomplete/invalid responses (logical inconsistencies, accelerometer data <3 valid days). No significant demographic differences existed between retained and excluded cases (p > 0.05). METHODS: Validated instruments measured: EBPs (Strengths and Difficulties Questionnaire, alpha = 0.79), parenting styles (EMBU short form: Rejection alpha = 0.890; Overprotection alpha = 0.824; Emotional Warmth alpha = 0.910), resilience (Connor-Davidson Resilience Scale, alpha = .970), and PA (IPAQ-SF MET-min/week, alpha = 0.936). Confirmatory factor analysis established measurement models (RMSEA = 0.026, CFI = 0.971, TLI = 0.970). Structural equation modeling with 5,000 bootstrap resamples (PROCESS Model 6) tested three mediation pathways: (1) Parenting --> PA --> EBPs; (2) Parenting --> Resilience --> EBPs; (3) Parenting --> PA --> Resilience --> EBPs. RESULTS: Emotional warmth significantly predicted reduced EBPs through increased PA (B = 0.862, p < 0.001) and resilience (B = 0.571, p < 0.001), with PA demonstrating the strongest independent mediation (effect = 0.544, 95% CI [0.460, 0.629]). Rejection exacerbated EBPs by suppressing PA (B = -0.318, p < 0.001) and resilience (B = -0.294, p < 0.001; total indirect effect = 0.412, CI [0.332, 0.503]). Overprotection influenced EBPs solely through reduced PA (effect = 0.102, CI [0.058, 0.158]), showing no significant resilience association. The full chained mediation (parenting --> PA --> resilience --> EBPs) was significant (effect = 0.075, CI [0.006, 0.145]), accounting for 24.23% of the total effect. CI - Copyright (c) 2025 Shi, Zhao and Lipowski. FAU - Shi, YiJie AU - Shi Y AD - Faculty of Physical Culture, Gdansk University of Physical Education and Sport, Gdansk, Poland. FAU - Zhao, Wei AU - Zhao W AD - College of Physical Education, Northwest Minzu University, Lanzhou, Gansu, China. FAU - Lipowski, Mariusz AU - Lipowski M AD - Faculty of Social and Humanities, WSB Merito University in Gdansk, Gdansk, Poland. LA - eng PT - Journal Article DEP - 20250707 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC12277388 OTO - NOTNLM OT - Chinese adolescents OT - emotional and behavioral problems OT - parenting style OT - physical activity OT - resilience COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/07/22 06:26 MHDA- 2025/07/22 06:27 PMCR- 2025/07/07 CRDT- 2025/07/22 04:46 PHST- 2024/08/27 00:00 [received] PHST- 2025/06/06 00:00 [accepted] PHST- 2025/07/22 06:27 [medline] PHST- 2025/07/22 06:26 [pubmed] PHST- 2025/07/22 04:46 [entrez] PHST- 2025/07/07 00:00 [pmc-release] AID - 10.3389/fpsyg.2025.1486949 [doi] PST - epublish SO - Front Psychol. 2025 Jul 7;16:1486949. doi: 10.3389/fpsyg.2025.1486949. eCollection 2025. PMID- 40692486 OWN - NLM STAT- MEDLINE DCOM- 20260117 LR - 20260329 IS - 1537-6613 (Electronic) IS - 0022-1899 (Print) IS - 0022-1899 (Linking) VI - 233 IP - 1 DP - 2026 Jan 17 TI - External Validation of Pediatric Pneumonia and Bronchiolitis Risk Scores to Predict Mortality in Children Hospitalized in Kenya: A Retrospective Cohort Study. PG - e230-e238 LID - 10.1093/infdis/jiaf377 [doi] AB - BACKGROUND: Acute lower respiratory tract infections (ALRIs) are a leading cause of pediatric mortality in low- and middle-income countries. In recent years, substantial research has been done to enhance risk stratification of children presenting with ALRIs, in a bid to improve health outcomes in resource-limited settings. We sought to analyze the performance of several pediatric ALRI risk scores in the prediction of mortality among children hospitalized with ALRIs in Kenya. METHODS: We retrospectively analyzed the data of 2182 children aged 2-24 months who were admitted to Kilifi County Referral Hospital, Kenya with severe ALRIs between January 2015 and December 2024. We evaluated the performance of 6 ALRI risk scores (RISC [HIV-negative], mRISC, RISC-Malawi, PERCH, PREPARE, and ReSVinet) in this population. Additionally, we created and evaluated a modified version of the ReSVinet score by including nutrition status. Discrimination was assessed using the area under the receiver operating characteristic curve (AUROC). RESULTS: The mid-upper arm circumference (MUAC) version of the RISC-Malawi score showed the highest discrimination for the outcome of in-hospital mortality (AUROC, 0.83; 95% confidence interval, .79-.86), whilst all other scores showed acceptable discrimination (AUROC, 0.70-0.79). The modification of ReSVinet to include nutrition status significantly improved its AUROC from 0.72 to 0.79. CONCLUSIONS: All risk scores showed at least fair performance in the prediction of in-hospital mortality within our dataset. The RISC-Malawi (MUAC) score appears to be the most promising candidate for future implementation; however, further research is needed to evaluate the calibration, feasibility, and clinical utility of these scores. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of Infectious Diseases Society of America. FAU - Gordon, Becky AU - Gordon B AUID- ORCID: 0009-0002-3739-179X AD - Usher Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, United Kingdom. AD - Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom. FAU - Nyiro, Joyce U AU - Nyiro JU AD - Epidemiology and Demography Department, Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya. FAU - Nair, Harish AU - Nair H AUID- ORCID: 0000-0002-9432-9100 AD - Usher Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, United Kingdom. AD - School of Public Health, Nanjing Medical University, Nanjing, China. AD - Medical Research Council/University of the Witwatersrand Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. FAU - Sheikh, Zakariya AU - Sheikh Z AUID- ORCID: 0000-0003-4147-4205 AD - Edinburgh Medical School, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom. FAU - Katama, Esther AU - Katama E AD - Epidemiology and Demography Department, Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya. FAU - Agoti, Charles N AU - Agoti CN AUID- ORCID: 0000-0002-2160-567X AD - Epidemiology and Demography Department, Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya. AD - School of Public Health, Pwani University, Kilifi, Kenya. FAU - Pei, Ruonan AU - Pei R AUID- ORCID: 0009-0003-2932-1473 AD - Usher Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, United Kingdom. FAU - Zar, Heather AU - Zar H AUID- ORCID: 0000-0002-9046-759X AD - Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa. AD - South African Medical Research Council Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa. FAU - Shi, Ting AU - Shi T AUID- ORCID: 0000-0002-4101-4535 AD - Usher Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, United Kingdom. LA - eng GR - WT_/Wellcome Trust/United Kingdom GR - 218529/Z/19/Z/Alan Turing Institute Wellcome/ GR - Health Data Research UK/ PT - Journal Article PT - Validation Study PL - United States TA - J Infect Dis JT - The Journal of infectious diseases JID - 0413675 SB - IM MH - Humans MH - Kenya/epidemiology MH - Retrospective Studies MH - Infant MH - Male MH - Female MH - Hospitalization/statistics & numerical data MH - Hospital Mortality MH - *Pneumonia/mortality MH - *Bronchiolitis/mortality MH - Child, Preschool MH - Risk Assessment/methods MH - ROC Curve MH - Risk Factors PMC - PMC12811851 OTO - NOTNLM OT - acute lower respiratory tract infections OT - pneumonia OT - risk scores OT - risk stratification COIS- Potential conflicts of interest. Z. S. is a shareholder of Evidence-Based Health Care, Ltd. H. N. reports grants from the Innovative Medicines Initiative, Pfizer, AstraZeneca, and MSD outside the submitted work; consulting fees from the Gates Foundation, Pfizer, GSK, and Sanofi; honoraria from AbbVie and AstraZeneca; support from Sanofi for attending meetings; and participation on advisory boards for GSK, Merck, Pfizer, Sanofi, Icosavax, Novavax, Resvinet, and World Health Organization outside the submitted work. T. S. has received funding from the National Institute of Health and Care Research outside the submitted work. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. EDAT- 2025/07/22 06:26 MHDA- 2026/01/17 12:31 PMCR- 2025/07/22 CRDT- 2025/07/22 04:24 PHST- 2025/04/23 00:00 [received] PHST- 2025/07/19 00:00 [accepted] PHST- 2026/01/17 12:31 [medline] PHST- 2025/07/22 06:26 [pubmed] PHST- 2025/07/22 04:24 [entrez] PHST- 2025/07/22 00:00 [pmc-release] AID - 8210160 [pii] AID - jiaf377 [pii] AID - 10.1093/infdis/jiaf377 [doi] PST - ppublish SO - J Infect Dis. 2026 Jan 17;233(1):e230-e238. doi: 10.1093/infdis/jiaf377. PMID- 40690508 OWN - NLM STAT- MEDLINE DCOM- 20250721 LR - 20261022 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 7 DP - 2025 TI - An illustration of multi-class roc analysis for predicting internet addiction among university students. PG - e0325855 LID - 10.1371/journal.pone.0325855 [doi] LID - e0325855 AB - The internet is one of the essential tools today, and its impact is particularly felt among university students. Internet addiction (IA) has become a serious public health issue worldwide. This multi-class classification study aimed to identify the potential predictors of IA by four severity levels among university students in Bangladesh. We used cross-sectional survey data from 424 university students from different universities in Bangladesh. Data was collected using a self-reported questionnaire, along with an IA test to assess addiction levels. We identified the important features related to IA using the Boruta algorithm. Predictions were made using different machine learning (ML) (decision tree (DT), random forest (RF), support vector machines (SVMs), and logistic regression (LR)) models. Their performance was assessed using confusion matrix parameters, receiver operating characteristics (ROC) curves, and k-fold cross-validation techniques for multi-class classification problems. The prevalence of severe IA was 3.77% among the participating university students in Bangladesh from July 15 to July 22, 2024. University students' backgrounds, depression, anxiety, stress, participation in physical activity, misbehaving with family members, memory loss symptoms, and being COVID-19-positive were selected as significant features for predicting IA. Overall, the RF (accuracy = 0.531, sensitivity = 0.200, specificity = 0.986, precision = 1.00, k-fold accuracy = 0.4858, micro-average area under curve (AUC) = 0.7798) more accurately predicted IA compared to other ML techniques. The ML framework for multi-class classification study can reveal significant risk factors and predict this behavioral addiction more precisely. It can help policymakers, stakeholders, and families better understand the situation and prevent this severe crisis by improving policy-making strategies, promoting mental health, and establishing effective university counseling services. Therefore, raising awareness among the younger generation and their parents about the predictors of IA is important. CI - Copyright: (c) 2025 Thity et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Thity, Nishat Tasnim AU - Thity NT AD - Department of Statistics and Data Science, Jahangirnagar University, Dhaka, Bangladesh. FAU - Rahman, Atikur AU - Rahman A AUID- ORCID: 0000-0003-3291-7836 AD - Department of Statistics and Data Science, Jahangirnagar University, Dhaka, Bangladesh. FAU - Dulmini, Adisha AU - Dulmini A AD - Department of Business and Law, University of Wollongong, New South Wales, Australia. FAU - Yasmin, Mst Nilufar AU - Yasmin MN AD - Department of Statistics and Data Science, Jahangirnagar University, Dhaka, Bangladesh. FAU - Rois, Rumana AU - Rois R AUID- ORCID: 0000-0002-0751-7104 AD - Department of Statistics and Data Science, Jahangirnagar University, Dhaka, Bangladesh. LA - eng PT - Journal Article DEP - 20250721 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Students/psychology MH - Universities MH - Male MH - Female MH - *Internet Addiction Disorder/epidemiology/diagnosis MH - Bangladesh/epidemiology MH - Young Adult MH - Cross-Sectional Studies MH - ROC Curve MH - Adult MH - Support Vector Machine MH - Adolescent MH - COVID-19/epidemiology MH - Surveys and Questionnaires MH - Machine Learning MH - Prevalence PMC - PMC12279137 COIS- The authors have declared that no competing interests exist. EDAT- 2025/07/21 18:32 MHDA- 2025/07/21 18:33 PMCR- 2025/07/21 CRDT- 2025/07/21 13:43 PHST- 2024/08/13 00:00 [received] PHST- 2025/05/16 00:00 [accepted] PHST- 2025/07/21 18:33 [medline] PHST- 2025/07/21 18:32 [pubmed] PHST- 2025/07/21 13:43 [entrez] PHST- 2025/07/21 00:00 [pmc-release] AID - PONE-D-24-30985 [pii] AID - 10.1371/journal.pone.0325855 [doi] PST - epublish SO - PLoS One. 2025 Jul 21;20(7):e0325855. doi: 10.1371/journal.pone.0325855. eCollection 2025. PMID- 40690430 OWN - NLM STAT- MEDLINE DCOM- 20250721 LR - 20260409 IS - 1940-087X (Electronic) IS - 1940-087X (Linking) IP - 221 DP - 2025 Jul 3 TI - The 6-Minute Frame Running Test - A Field-based Cardiopulmonary Exercise Test for Individuals with Cerebral Palsy. LID - 10.3791/67691 [doi] AB - Cerebral palsy (CP) is a diverse childhood-onset motor disability that varies significantly in severity and impact. Individuals with more severe forms of CP, particularly those with whole-body involvement, often face substantial barriers to physical activity. These barriers are compounded by the limited availability of exercise options that can accommodate their specific needs. The forms of physical activity that may be available typically involve low levels of aerobic demand, which may not be sufficient to maintain and/or improve cardiovascular health. However, Frame Running, a parasport performed on a three-wheeled running frame, allows individuals with CP to participate in aerobic exercise at high intensity. The running frame, designed specifically for individuals with motor impairments such as CP, enables the assessment of aerobic capacity in a population otherwise excluded from traditional exercise modalities. The 6-Minute Frame Running Test (6-MFRT) has been validated as an effective measure for estimating maximum aerobic capacity in individuals with CP. It is easy to perform and only requires a running frame, a 200-400 m track, a heart rate monitor, a measuring tape or wheel, and a stopwatch. Thus, the 6-MFRT serves as a practical and reliable measure of aerobic capacity that can be used to assess health-related fitness and evaluate the effect of training interventions. FAU - Corell, Linnea AU - Corell L AD - Department of Women's and Children's Health, Karolinska Institutet. FAU - Hjalmarsson, Emma AU - Hjalmarsson E AD - Department of Women's and Children's Health, Karolinska Institutet; Medical Unit Allied Health Professionals, Women's Health and Allied Health Professionals Theme, Karolinska University Hospital. FAU - Bolster, Eline AU - Bolster E AD - Research Centre for Healthy and Sustainable Living, Research group Lifestyle and Health, Utrecht University of Applied Sciences. FAU - van Schie, Petra AU - van Schie P AD - Department of Rehabilitation Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam; Amsterdam Movement Sciences, Rehabilitation & Development. FAU - Buizer, Annemieke I AU - Buizer AI AD - Department of Rehabilitation Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam; Amsterdam Movement Sciences, Rehabilitation & Development; Emma Children&s Hospital, Amsterdam UMC. FAU - Bjork, Lars AU - Bjork L AD - Department of Women's and Children's Health, Karolinska Institutet. FAU - Norrbom, Jessica AU - Norrbom J AD - Department of Physiology and Pharmacology, Karolinska Institutet. FAU - Von Walden, Ferdinand AU - Von Walden F AD - Department of Women's and Children's Health, Karolinska Institutet; ferdinand.von.walden@ki.se. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Video-Audio Media DEP - 20250703 PL - United States TA - J Vis Exp JT - Journal of visualized experiments : JoVE JID - 101313252 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology MH - *Exercise Test/methods/instrumentation MH - *Running/physiology EDAT- 2025/07/21 18:31 MHDA- 2025/07/21 18:32 CRDT- 2025/07/21 13:23 PHST- 2025/07/21 18:32 [medline] PHST- 2025/07/21 18:31 [pubmed] PHST- 2025/07/21 13:23 [entrez] AID - 10.3791/67691 [doi] PST - epublish SO - J Vis Exp. 2025 Jul 3;(221). doi: 10.3791/67691. PMID- 40689479 OWN - NLM STAT- MEDLINE DCOM- 20250721 LR - 20250724 IS - 2047-2986 (Electronic) IS - 2047-2978 (Print) IS - 2047-2978 (Linking) VI - 15 DP - 2025 Jul 21 TI - Prevalence of malnutrition and associated factors in Chinese children and adolescents aged 3-14 years using machine learning algorithms. PG - 04204 LID - 10.7189/jogh.15.04204 [doi] LID - 04204 AB - BACKGROUND: Child malnutrition represents a critical global public health issue and it is characterised by high prevalence and severe long-term consequences for growth and development. A better understanding of its contributory factors is essential to inform the design of targeted prevention strategies and evidence-based interventions. We aimed to estimate the prevalence of malnutrition in children and adolescents aged 3-14 years, and further to identify promising factors associated with child malnutrition using machine learning algorithms. METHODS: Thirty kindergartens and 26 schools were randomly selected from Beijing and Tangshan. Child malnutrition was defined according to WHO standards. Factors for child malnutrition were selected by Logistic regression and three ensemble learning algorithms. An open-access web platform was developed to facilitate calculating probabilities of child malnutrition. RESULTS: Total 18 503 children and adolescents were surveyed, and 10.93% (n = 2022) of them were found to be malnourished. Random forest emerged as the best model, as it carried the highest area under the receiver operating characteristic curve (AUROC) at 0.929. Under the implementation of random forest, top eight factors that formed the optimal set for child malnutrition prediction were identified, including age, frequency of fast food intake, frequency of late-night snacking, family history of diabetes, duration of breastfeeding, sedentary time, and parental body mass index. Further Logistic regression analyses confirmed the predictive significance of these individual factors. CONCLUSIONS: We have identified eight contributory factors for malnutrition in 3-14-year-old children and adolescents in Beijing and Tangshan, with their prediction performance optimal under random forest. More studies among independent populations are warranted to validate our findings. CI - Copyright (c) 2025 by the Journal of Global Health. All rights reserved. FAU - Zheng, Fangjieyi AU - Zheng F AD - Centre for Evidence-Based Medicine, Capital Institute of Paediatrics, Beijing, People's Republic of China. FAU - Chen, Kening AU - Chen K AD - China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China. FAU - Zhang, Xiaoqian AU - Zhang X AD - Graduate School, Beijing University of Chinese Medicine, Beijing, People's Republic of China. AD - Department of Paediatrics, China-Japan Friendship Hospital, Beijing, People's Republic of China. FAU - Wang, Qiong AU - Wang Q AD - Graduate School, Beijing University of Chinese Medicine, Beijing, People's Republic of China. AD - Department of Paediatrics, China-Japan Friendship Hospital, Beijing, People's Republic of China. FAU - Zhang, Zhixin AU - Zhang Z AD - Department of Paediatrics, China-Japan Friendship Hospital, Beijing, People's Republic of China. AD - International Medical Services, China-Japan Friendship Hospital, Beijing, People's Republic of China. FAU - Niu, Wenquan AU - Niu W AD - Centre for Evidence-Based Medicine, Capital Institute of Paediatrics, Beijing, People's Republic of China. LA - eng PT - Journal Article DEP - 20250721 PL - Scotland TA - J Glob Health JT - Journal of global health JID - 101578780 RN - Chinese people SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Male MH - Algorithms MH - *Child Nutrition Disorders/epidemiology MH - China/epidemiology MH - *Machine Learning MH - Prevalence MH - Risk Factors MH - East Asian People PMC - PMC12278689 COIS- Disclosure of interest: The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests. EDAT- 2025/07/21 12:39 MHDA- 2025/07/21 12:40 PMCR- 2025/07/21 CRDT- 2025/07/21 07:53 PHST- 2025/07/21 12:40 [medline] PHST- 2025/07/21 12:39 [pubmed] PHST- 2025/07/21 07:53 [entrez] PHST- 2025/07/21 00:00 [pmc-release] AID - jogh-15-04204 [pii] AID - 10.7189/jogh.15.04204 [doi] PST - epublish SO - J Glob Health. 2025 Jul 21;15:04204. doi: 10.7189/jogh.15.04204. PMID- 40688540 OWN - NLM STAT- MEDLINE DCOM- 20250721 LR - 20260703 IS - 1520-6394 (Electronic) IS - 1091-4269 (Print) IS - 1091-4269 (Linking) VI - 2025 DP - 2025 TI - Internet Addiction and Depressive Symptoms in University Students: Latent Profiles, Network Structure, and Symptomatic Pathways to Suicide Risk. PG - 4591408 LID - 10.1155/da/4591408 [doi] LID - 4591408 AB - Background: Internet addiction and depression frequently co-occur among university students, resulting in amplified functional deterioration and treatment resistance. Despite established bidirectional relationships, existing research has predominantly examined linear associations and treated these conditions as single global constructs. This study integrated person-centered and network-based approaches to identify distinct symptom profiles of Internet addiction and depressive symptoms, examine sociodemographic predictors of profile membership, and uncover interconnected symptom networks within high-risk populations among Chinese university students. Methods: A multicenter cross-sectional study was conducted from April to July 2024. Data were collected through a web-based survey incorporating validated instruments for Internet addiction, depression, and suicide risk assessment. Latent profile analysis was employed to identify distinct symptom profiles, followed by multivariate logistic regression to examine sociodemographic predictors. Network analysis was performed within the high-risk profile to unveil symptom interactions, central symptoms, bridge symptoms, and symptomatic pathways to suicide risk. Results: Among 30,992 participants, latent profile analysis identified three distinct groups: Healthy profile (59.31%), at-risk profile (35.06%), and comorbidity profile (5.63%). Students who were female, ethnic minorities, in higher grade levels, and had prolonged Internet use showed increased risks of problematic profiles. Conversely, enrollment in bachelor's programs, science and medical majors, higher household income, and regular physical activity demonstrated protective effects. Network analysis revealed Internet preoccupation and fatigue as central symptoms, identified key bridge symptoms (e.g., offline negative affect, difficulty concentrating) linking the symptom clusters, and highlighted Internet withdrawal symptoms and depressed mood as critical pathways to suicide risk within the comorbidity profile. Conclusion: This study identified distinct profiles of Internet addiction and depression comorbidity, with specific sociodemographic and lifestyle predictors informing targeted screening strategies. Network analysis revealed central symptoms and specific bridge symptoms connecting the conditions, while also identifying critical pathways to suicide risk in the Comorbidity profile, providing empirical evidence for developing precise and effective interventions. CI - Copyright (c) 2025 Yuan Li et al. Depression and Anxiety published by John Wiley & Sons Ltd. FAU - Li, Yuan AU - Li Y AUID- ORCID: 0000-0002-5550-0307 AD - Department of Nursing, West China Second University Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu 610041, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu 610041, China. AD - Department of Neonatology, West China Second University Hospital, Sichuan University, Chengdu 610041, China. FAU - Shi, Jing AU - Shi J AUID- ORCID: 0009-0006-2629-9786 AD - Department of Education, Sichuan Province, Chengdu 610041, Sichuan, China. FAU - Luo, Biru AU - Luo B AUID- ORCID: 0000-0002-4889-2429 AD - Department of Nursing, West China Second University Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu 610041, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu 610041, China. FAU - Xiong, Anqi AU - Xiong A AUID- ORCID: 0009-0000-0207-6808 AD - West China School of Nursing, Sichuan University, Chengdu 610041, China. FAU - Xiong, Siqi AU - Xiong S AUID- ORCID: 0009-0004-3219-0184 AD - School of Nursing, Chengdu Medical College, Chengdu 610083, China. FAU - Wang, Jing AU - Wang J AUID- ORCID: 0009-0002-9107-5405 AD - School of Nursing, Ya'an Polytechnic College, Ya'an 625000, China. FAU - Liao, Shujuan AU - Liao S AUID- ORCID: 0000-0001-5409-2893 AD - Department of Nursing, West China Second University Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu 610041, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu 610041, China. LA - eng PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20250712 PL - United States TA - Depress Anxiety JT - Depression and anxiety JID - 9708816 SB - IM MH - Humans MH - Female MH - Male MH - *Students/statistics & numerical data/psychology MH - *Internet Addiction Disorder/epidemiology/psychology MH - Universities MH - Cross-Sectional Studies MH - Young Adult MH - *Depression/epidemiology/psychology MH - Adult MH - China/epidemiology MH - Adolescent MH - *Suicide/statistics & numerical data/psychology MH - Comorbidity PMC - PMC12276061 OTO - NOTNLM OT - depressive symptoms OT - internet addiction OT - latent profile analysis OT - network analysis OT - suicide risk OT - university students COIS- The authors declare no conflicts of interest. EDAT- 2025/07/21 17:24 MHDA- 2025/07/21 17:25 PMCR- 2025/07/12 CRDT- 2025/07/21 07:29 PHST- 2025/01/15 00:00 [received] PHST- 2025/04/29 00:00 [revised] PHST- 2025/06/19 00:00 [accepted] PHST- 2025/07/21 17:25 [medline] PHST- 2025/07/21 17:24 [pubmed] PHST- 2025/07/21 07:29 [entrez] PHST- 2025/07/12 00:00 [pmc-release] AID - 10.1155/da/4591408 [doi] PST - epublish SO - Depress Anxiety. 2025 Jul 12;2025:4591408. doi: 10.1155/da/4591408. eCollection 2025. PMID- 40686825 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260918 IS - 2673-253X (Electronic) IS - 2673-253X (Linking) VI - 7 DP - 2025 TI - Use of telehealth for measurement of anthropometrics in toddlers and their parents. PG - 1548607 LID - 10.3389/fdgth.2025.1548607 [doi] LID - 1548607 AB - INTRODUCTION: The use of telehealth (e.g., live video calling) to collect anthropometric data in toddlers and their parents to increase participation in lifestyle interventions holds promise. But, there is limited evidence to support reliability of telehealth for the collection of these measures. This study aimed to determine the reliability of use of telehealth with parents to collect anthropometric and blood pressure measures on themselves and anthropometric measures on their toddler and determine the acceptability of instruction. METHODS: This cross-sectional study was conducted as part of the developmental phase of a larger study. Research staff instructed parents via video call to measure their own and their toddler's anthropometrics, and their own blood pressure. Next, research staff collected the same measurements in-person. Intraclass Correlation Coefficients (ICC), relative technical error of measurement (TEM) and reliability coefficient values were computed. RESULTS: Thirty-seven parent/toddler dyads were enrolled in the study. ICC values for parent vs. research staff measured parental height and weight were 0.98 and 0.99, respectively, and relative TEM values were 0.44% and 0.14%, respectively. ICC values for parent vs. research staff measured toddler height and weight were 0.98 and 0.99, and relative TEM values were 1.60% and 0.82%, respectively. ICC values for parent vs. research measured systolic and diastolic blood pressure were 0.86 and 0.89 respectively. DISCUSSION: Parental self-measurement of height, weight, and blood pressure, and measurement of toddler height and weight is reliable and acceptable to parents when performed using telehealth. CI - (c) 2025 Farabi, Schwarz, Lee-Robinson, Fiechtner, Davila-Roman, Tabak and Haire-Joshu. FAU - Farabi, Sarah S AU - Farabi SS AD - Goldfarb School of Nursing, Office of Nursing Research, Saint Louis, MO, United States. AD - Department of Medicine, Division of Nutritional Science & Obesity Medicine, Washington University School of Medicine in St. Louis, Saint Louis, MO, United States. FAU - Schwarz, Cindy AU - Schwarz C AD - WashU Public Health, Washington University in St. Louis, Saint Louis, MO, United States. FAU - Lee-Robinson, Bria AU - Lee-Robinson B AD - WashU Public Health, Washington University in St. Louis, Saint Louis, MO, United States. FAU - Fiechtner, Lauren G AU - Fiechtner LG AD - Division of Gastroenterology and General Academic Pediatrics, Mass General for Children, Boston, MA, United States. FAU - Davila-Roman, Victor AU - Davila-Roman V AD - Department of Medicine, Division of Cardiology, Washington University School of Medicine in St. Louis, Saint Louis, MO, United States. FAU - Tabak, Rachel G AU - Tabak RG AD - WashU Public Health, Washington University in St. Louis, Saint Louis, MO, United States. FAU - Haire-Joshu, Debra AU - Haire-Joshu D AD - WashU Public Health, Washington University in St. Louis, Saint Louis, MO, United States. LA - eng GR - P30 DK056341/DK/NIDDK NIH HHS/United States GR - P30 DK092950/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20250704 PL - Switzerland TA - Front Digit Health JT - Frontiers in digital health JID - 101771889 PMC - PMC12271149 OTO - NOTNLM OT - anthropometrics OT - parent OT - reliability OT - toddler OT - virtualtelehealth COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/07/21 17:24 MHDA- 2025/07/21 17:25 PMCR- 2025/07/04 CRDT- 2025/07/21 07:09 PHST- 2024/12/20 00:00 [received] PHST- 2025/06/20 00:00 [accepted] PHST- 2025/07/21 17:25 [medline] PHST- 2025/07/21 17:24 [pubmed] PHST- 2025/07/21 07:09 [entrez] PHST- 2025/07/04 00:00 [pmc-release] AID - 10.3389/fdgth.2025.1548607 [doi] PST - epublish SO - Front Digit Health. 2025 Jul 4;7:1548607. doi: 10.3389/fdgth.2025.1548607. eCollection 2025. PMID- 40686226 OWN - NLM STAT- MEDLINE DCOM- 20251001 LR - 20251003 IS - 1536-4801 (Electronic) IS - 0277-2116 (Print) IS - 0277-2116 (Linking) VI - 81 IP - 4 DP - 2025 Oct TI - Gluten-free oats and diet quality in children and youth with celiac disease. PG - 1070-1078 LID - 10.1002/jpn3.70168 [doi] AB - OBJECTIVES: Celiac disease (CD) requires lifelong adherence to a strict gluten-free diet (GFD). The GFD is associated with higher intakes of fat, added sugars, and glycemic index (GI) and lower diet quality (DQ) in youth with CD. Gluten-free oats (GF-oats) are safe for CD youth, but few studies have studied the nutritional contribution of GF-oats consumption on DQ in children with CD. We hypothesized that youth with CD who consume GF-oats as part of their GFD will have higher DQ, micronutrient and fiber content, and lower GI than a GFD without GF-oats. METHODS: A case-control analysis using age-sex matched controls was performed in youth (ages 3-18 years) with CD in a 1:2 (N = 16 GF-oats cases: N = 32 Oat-free cases) ratio to compare differences in macro- and micronutrient (Canadian nutrient file), GI (mixed-method approach), DQ (healthy-eating index) between case-controls using validated methodologies. Dietary adequacy was determined by comparisons to dietary reference intakes (DRI) and to gluten free food guide (GFFG) recommendations. RESULTS: GF-oats did not significantly improve DQ (68.5 +/- 16 [cases] vs. 64.3 +/- 13 [controls], macro- and micronutrient, fiber intake, or the percentage of children meeting DRIs (p > 0.05). Children consuming GF-oats had lower dietary GI than children not consuming GF-oats (50.6 +/- 2.4 [+GF-oats] vs. 56.1 +/- 7.4 [-GF-oats]; p = 0.05). No differences in DQ occurred (+/-GF-oats) when following GFFG recommendations. CONCLUSIONS: GF-oats are not a major determining factor of overall DQ in CD youth. Regardless of the oats in the GFD, following the pediatric GFFG was more important to DQ. CI - (c) 2025 The Author(s). Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Mager, Diana R AU - Mager DR AUID- ORCID: 0000-0002-5558-8783 AD - Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada. AD - Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada. FAU - Jiang, Zhiqian AU - Jiang Z AD - Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada. FAU - Rashke, Samantha AU - Rashke S AD - Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada. FAU - Turner, Justine M AU - Turner JM AD - Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada. AD - Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada. LA - eng GR - Stollery Children's Hospital Foundation through the Women and Children's Health Research Institute (2023-2025)/ GR - the Canadian Behavioral Interventions and Trials Network (2023-2024)/ GR - the Alberta Diabetes Institute (2022-2023)/ PT - Journal Article DEP - 20250721 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 RN - 0 (Dietary Fiber) RN - 0 (Micronutrients) SB - IM MH - Humans MH - Child MH - *Diet, Gluten-Free MH - *Celiac Disease/diet therapy MH - Adolescent MH - Male MH - Female MH - *Avena MH - Case-Control Studies MH - Child, Preschool MH - Dietary Fiber/administration & dosage MH - Glycemic Index MH - Micronutrients PMC - PMC12484711 OTO - NOTNLM OT - avenin OT - gluten-free diet OT - nutritional quality COIS- The authors declare no conflict of interest. EDAT- 2025/07/21 06:30 MHDA- 2025/10/01 06:29 PMCR- 2025/10/01 CRDT- 2025/07/21 05:13 PHST- 2025/05/30 00:00 [revised] PHST- 2025/04/18 00:00 [received] PHST- 2025/06/06 00:00 [accepted] PHST- 2025/10/01 06:29 [medline] PHST- 2025/07/21 06:30 [pubmed] PHST- 2025/07/21 05:13 [entrez] PHST- 2025/10/01 00:00 [pmc-release] AID - JPN370168 [pii] AID - 10.1002/jpn3.70168 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2025 Oct;81(4):1070-1078. doi: 10.1002/jpn3.70168. Epub 2025 Jul 21. PMID- 40685764 OWN - NLM STAT- MEDLINE DCOM- 20250721 LR - 20250806 IS - 2162-3279 (Electronic) VI - 15 IP - 7 DP - 2025 Jul TI - A FastSurfer Database for Age-Specific Brain Volumes in Healthy Children: A Tool for Quantifying Localized and Global Brain Volume Alterations in Pediatric Patients. PG - e70689 LID - 10.1002/brb3.70689 [doi] LID - e70689 AB - PURPOSE: MRI-based whole-brain manual segmentation methods are considered the gold standard for brain volumetric analysis, but are time-consuming and prone to human error. Automated segmentation tools like FreeSurfer can identify differences in brain volumes between healthy and non-healthy individuals. Deep-learning-based segmentation tools, such as FastSurfer, offer faster processing times, but further validation is needed, particularly in pediatric cases. This study aims to compare FastSurfer with FreeSurfer in a pediatric cohort and compare the volume estimates with previously published reference values. METHODS: A multicenter cohort of 448 subjects aged 4-18 years from three centers was used to compare FastSurfer with FreeSurfer. Validation metrics, including the Dice Similarity Coefficient (DSC), relative volume differences (RVD), and intraclass correlation coefficient (ICC), were computed. Hemispheric asymmetries were assessed by calculating a hemispheric asymmetry index. FINDINGS: The segmentation methods demonstrated high agreement, with a mean DSC across subjects and regions of interest of 0.90 (95% CI: 0.79; 0.95), RVD of 0.3% (95% CI: -7.6%; 7.4%), and ICC of 0.87 (95% CI: 0.52; 0.94). After a visual inspection, which led to the exclusion of 12 subjects with segmentation errors, growth charts for relative volume estimates of 15 anatomical brain regions were generated, revealing varying growth patterns across ages. A potential clinical application is illustrated by plotting a patient's data on these growth charts, showing a specific atrophy pattern. CONCLUSION: To our knowledge, this is the first study investigating the use of FastSurfer in volumetric analysis of a pediatric population. Our findings suggest that FastSurfer is a reliable segmentation tool for pediatric data and is particularly promising for clinical practice due to its high accuracy despite rapid processing times. The morphometric data, growth charts, and code are publicly accessible. CI - (c) 2025 The Author(s). Brain and Behavior published by Wiley Periodicals LLC. FAU - Zughayyar, Ibrahim AU - Zughayyar I AUID- ORCID: 0009-0000-4598-8161 AD - Institute of Neuroradiology, Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Berlin, Germany. FAU - Bauer, Martin AU - Bauer M AD - Institute of Medical Psychology, Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Berlin, Germany. FAU - Guttler, Christopher AU - Guttler C AD - Institute of Neuroradiology, Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Berlin, Germany. FAU - de Almeida Marcelino, Ana Luisa AU - de Almeida Marcelino AL AUID- ORCID: 0000-0002-3291-7222 AD - Department of Neurology, Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Movement Disorders and Neuromodulation Unit, Berlin, Germany. FAU - Kuhne, Fabienne AU - Kuhne F AD - Institute of Neuroradiology, Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Berlin, Germany. AD - Department of Neonatology, Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Berlin, Germany. FAU - Buss, Claudia AU - Buss C AD - Institute of Medical Psychology, Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Berlin, Germany. AD - German Center of Mental Health, Berlin Potsdam Partner Site, Berlin, Germany. FAU - Heim, Christine AU - Heim C AD - Institute of Medical Psychology, Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Berlin, Germany. AD - German Center of Mental Health, Berlin Potsdam Partner Site, Berlin, Germany. AD - NeuroCure Cluster of Excellence, Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Berlin, Germany. FAU - Aigner, Annette AU - Aigner A AD - Institute of Biometry and Clinical Epidemiology, Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat Zu Berlin, Berlin, Germany. AD - Center For Stroke Research Berlin, Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat Zu Berlin, Berlin, Germany. FAU - Tietze, Anna AU - Tietze A AD - Institute of Neuroradiology, Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Berlin, Germany. FAU - Dell'Orco, Andrea AU - Dell'Orco A AUID- ORCID: 0000-0002-3964-8360 AD - Institute of Neuroradiology, Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Berlin, Germany. LA - eng GR - SFB295RETUNE/Deutsche Forschungsgemeinschaft/ GR - 4247788381/Deutsche Forschungsgemeinschaft - Collaborative Research Centre TRR 295/ GR - 01GL1743A/Bundesministerium fur Bildung und Forschung/ GR - EVF-BUA-2022-694/Einstein Stiftung Berlin/ PT - Journal Article PT - Multicenter Study PL - United States TA - Brain Behav JT - Brain and behavior JID - 101570837 SB - IM MH - Humans MH - Child MH - Child, Preschool MH - *Brain/diagnostic imaging/anatomy & histology MH - Adolescent MH - *Magnetic Resonance Imaging/methods MH - Male MH - Female MH - Organ Size MH - *Image Processing, Computer-Assisted/methods MH - Databases, Factual MH - *Neuroimaging/methods MH - Cohort Studies MH - Reference Values PMC - PMC12277543 OTO - NOTNLM OT - FastSurfer OT - FreeSurfer OT - automated segmentation OT - brain volumetry OT - hemispheric asymmetries OT - neuroimaging OT - pediatric MRI COIS- The authors declare no conflicts of interest. EDAT- 2025/07/21 06:30 MHDA- 2025/07/21 06:31 PMCR- 2025/07/20 CRDT- 2025/07/21 02:43 PHST- 2025/05/19 00:00 [revised] PHST- 2024/10/13 00:00 [received] PHST- 2025/06/23 00:00 [accepted] PHST- 2025/07/21 06:31 [medline] PHST- 2025/07/21 06:30 [pubmed] PHST- 2025/07/21 02:43 [entrez] PHST- 2025/07/20 00:00 [pmc-release] AID - BRB370689 [pii] AID - 10.1002/brb3.70689 [doi] PST - ppublish SO - Brain Behav. 2025 Jul;15(7):e70689. doi: 10.1002/brb3.70689. PMID- 40684806 OWN - NLM STAT- MEDLINE DCOM- 20250828 LR - 20250828 IS - 1872-7697 (Electronic) IS - 0167-8760 (Linking) VI - 215 DP - 2025 Sep TI - Event Related Potential (ERP) markers of food-related inhibitory control are poor predictors of calorie and carbohydrate intake: A multiverse analysis. PG - 113223 LID - S0167-8760(25)00719-6 [pii] LID - 10.1016/j.ijpsycho.2025.113223 [doi] AB - Multiverse analyses strengthen the robustness of psychophysiological research by evaluating the influence of various analytical choices on results. The relationship between neural measures of inhibitory control and food intake is one area where researchers face multiple analytical decisions regarding inclusion and operationalization of variables. Although individuals with higher inhibitory control generally exhibit better diet-related outcomes, the relationship between event-related potential (ERP) markers of inhibitory control and food intake is inconsistent, calling into question the reliability of results. We conducted a multiverse analysis where 16 models were used to test a multiverse of relationships between ERP indices of inhibitory control and caloric or carbohydrate intake while controlling for age, biological sex, weight, and body mass index (BMI). No-go and difference (i.e., no-go minus go) amplitudes for N2 and P3 ERP components were used as indices of inhibitory control. Across four independent studies, 288 participants (M(age) = 25.89, SD(age) = 7.50) completed a high-calorie go/no-go task while ERP data were recorded. Food intake was recorded using the online Automated Self-Administered 24-hour Dietary Assessment Tool. Results generally found no significant relationship between ERP measures and calorie or carbohydrate intake. Biological males, heavier individuals, and those with higher BMIs tended to consume more food. Inhibitory control, as measured by the N2 and P3 ERP components during a high-calorie go/no-go task, does not consistently relate to food intake in the current multiverse analysis. Other cognitive and diet-related factors, like reward sensitivity and dietary restraint, need consideration when testing the link between inhibitory control and diet. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Carbine, Kaylie A AU - Carbine KA AD - Department of Psychology, Brigham Young University, Provo, UT 84602, United States of America. Electronic address: kaylie_carbine@byu.edu. FAU - LeCheminant, James D AU - LeCheminant JD AD - Department of Nutrition, Dietetics, & Food Science, Brigham Young University, Provo, UT 84602, United States of America. FAU - Larson, Michael J AU - Larson MJ AD - Department of Psychology, Brigham Young University, Provo, UT 84602, United States of America; Neuroscience Center, Brigham Young University, Provo, UT 84602, United States of America. LA - eng PT - Journal Article DEP - 20250718 PL - Netherlands TA - Int J Psychophysiol JT - International journal of psychophysiology : official journal of the International Organization of Psychophysiology JID - 8406214 RN - 0 (Dietary Carbohydrates) SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - *Inhibition, Psychological MH - *Evoked Potentials/physiology MH - Young Adult MH - *Dietary Carbohydrates/administration & dosage MH - *Energy Intake/physiology MH - Electroencephalography MH - *Eating/physiology MH - Adolescent OTO - NOTNLM OT - Calories OT - Carbohydrates OT - Food-related inhibitory control OT - Multiverse analysis OT - N2 ERP OT - P3 ERP COIS- Declaration of competing interest None. EDAT- 2025/07/21 00:30 MHDA- 2025/08/31 20:05 CRDT- 2025/07/20 19:30 PHST- 2024/11/30 00:00 [received] PHST- 2025/07/03 00:00 [revised] PHST- 2025/07/15 00:00 [accepted] PHST- 2025/08/31 20:05 [medline] PHST- 2025/07/21 00:30 [pubmed] PHST- 2025/07/20 19:30 [entrez] AID - S0167-8760(25)00719-6 [pii] AID - 10.1016/j.ijpsycho.2025.113223 [doi] PST - ppublish SO - Int J Psychophysiol. 2025 Sep;215:113223. doi: 10.1016/j.ijpsycho.2025.113223. Epub 2025 Jul 18. PMID- 40683623 OWN - NLM STAT- MEDLINE DCOM- 20260111 LR - 20260511 IS - 1876-2867 (Electronic) IS - 1876-2859 (Linking) VI - 26 IP - 1 DP - 2026 Jan-Feb TI - Major Depressive Disorder and Cardiovascular Disease Risk in Children and Adolescents. PG - 103112 LID - S1876-2859(25)00337-7 [pii] LID - 10.1016/j.acap.2025.103112 [doi] AB - OBJECTIVE: Major depressive disorder (MDD) in youth is an independent risk factor for premature cardiovascular disease (CVD). While previous research has considered individual CVD risk factors in relation to depression, this study examined the association between depression and CVD risk among children and adolescents with MDD using a validated composite measure. METHODS: Youth with MDD were recruited through an outpatient psychiatry program and underwent semistructured psychiatric diagnostic assessment to confirm diagnosis. Healthy control participants were recruited from community settings. All participants completed the Center for Epidemiological Studies Depression Scale for Children to assess depressive symptoms. The continuous metabolic syndrome score, a validated measure for cardiometabolic risk assessment in youth, was computed using aggregated standardized z-scores of CVD risk factors, including fasting blood glucose, body mass index, blood pressure, fasting triglycerides, and high-density lipoprotein cholesterol. Hierarchical multiple regression models tested the association between depression (diagnosis and symptoms) and CVD risk while accounting for covariates. RESULTS: Participants (N=277; 73.6% female) had a mean age of 15.2 (SD=1.8) years. Cardiovascular disease risk was significantly higher among youth with depression (n=196, mean=0.77, SD=2.98) compared with healthy controls (n=81, mean=-0.39, SD=2.77; P=.002). Depression diagnosis and depressive symptoms were associated with increased CVD risk (beta=0.40, P=.004; beta=0.15, P=.02, respectively), after adjusting for covariates. CONCLUSIONS: Adolescents with MDD demonstrate increased cardiovascular disease risk compared with healthy youth, highlighting early evidence of association between depression and cardiovascular disease. Consequently, childhood and adolescence may serve as crucial periods for preventive intervention targeting cardiovascular health among youth with depression. CI - Copyright (c) 2026 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved. FAU - Muha, Jessica AU - Muha J AD - Neurosciences and Mental Health (J Muha, SC Campisi, K Tsujimoto, E Tu, and DJ Korczak), SickKids Research Institute, Toronto, Canada; Institute of Medical Science (J Muha), Temerty Faculty of Medicine, University of Toronto, Canada. FAU - Campisi, Susan C AU - Campisi SC AD - Neurosciences and Mental Health (J Muha, SC Campisi, K Tsujimoto, E Tu, and DJ Korczak), SickKids Research Institute, Toronto, Canada; Nutrition and Dietetics Program (SC Campisi), Clinical Public Health Division, Dalla Lana School of Public Health, University of Toronto, Canada. FAU - Tsujimoto, Kimberley AU - Tsujimoto K AD - Neurosciences and Mental Health (J Muha, SC Campisi, K Tsujimoto, E Tu, and DJ Korczak), SickKids Research Institute, Toronto, Canada. FAU - Tu, Eric AU - Tu E AD - Neurosciences and Mental Health (J Muha, SC Campisi, K Tsujimoto, E Tu, and DJ Korczak), SickKids Research Institute, Toronto, Canada; Department of Psychology (E Tu), York University, Toronto, Canada. FAU - Agarwal, Sri Mahavir AU - Agarwal SM AD - Centre for Addiction and Mental Health (SM Agarwal), Toronto, Canada; Department of Psychiatry (SM Agarwal and DJ Korczak), Temerty Faculty of Medicine, University of Toronto, Canada; Banting & Best Diabetes Centre (SM Agarwal), Toronto, Canada. FAU - Toulany, Alene AU - Toulany A AD - Institute of Health Policy (A Toulany), Management and Evaluation, University of Toronto, Canada; Division of Adolescent Medicine (A Toulany), The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Paediatrics (A Toulany), Temerty Faculty of Medicine, University of Toronto, Canada; ICES (A Toulany), Toronto, Ontario, Canada; Child Health Evaluative Sciences (A Toulany), SickKids Research Institute, Toronto, Ontario, Canada. FAU - Hamza, Chloe A AU - Hamza CA AD - Department of Applied Psychology and Human Development (CA Hamza), Ontario Institute for Studies in Education, University of Toronto, Ontario, Canada. FAU - Korczak, Daphne J AU - Korczak DJ AD - Neurosciences and Mental Health (J Muha, SC Campisi, K Tsujimoto, E Tu, and DJ Korczak), SickKids Research Institute, Toronto, Canada; Department of Psychiatry (SM Agarwal and DJ Korczak), Temerty Faculty of Medicine, University of Toronto, Canada; Department of Psychiatry (DJ Korczak), Hospital for Sick Children, Toronto, Canada. Electronic address: daphne.korczak@sickkids.ca. LA - eng PT - Journal Article DEP - 20250717 PL - United States TA - Acad Pediatr JT - Academic pediatrics JID - 101499145 RN - 0 (Triglycerides) RN - 0 (Blood Glucose) RN - 0 (Cholesterol, HDL) SB - IM MH - Humans MH - *Major Depressive Disorder/epidemiology/complications MH - Adolescent MH - Female MH - Male MH - *Cardiovascular Diseases/epidemiology MH - Child MH - Case-Control Studies MH - Risk Factors MH - Heart Disease Risk Factors MH - Body Mass Index MH - Triglycerides/blood MH - Regression Analysis MH - Blood Pressure MH - Blood Glucose MH - Cholesterol, HDL/blood MH - Metabolic Syndrome/epidemiology OTO - NOTNLM OT - Cardiovascular disease OT - Child/adolescent psychiatry OT - Depression OT - Metabolism COIS- Declaration of Competing Interest The authors have no conflicts of interest to disclose. EDAT- 2025/07/20 04:03 MHDA- 2026/01/12 00:37 CRDT- 2025/07/19 19:34 PHST- 2025/02/03 00:00 [received] PHST- 2025/06/25 00:00 [revised] PHST- 2025/07/01 00:00 [accepted] PHST- 2026/01/12 00:37 [medline] PHST- 2025/07/20 04:03 [pubmed] PHST- 2025/07/19 19:34 [entrez] AID - S1876-2859(25)00337-7 [pii] AID - 10.1016/j.acap.2025.103112 [doi] PST - ppublish SO - Acad Pediatr. 2026 Jan-Feb;26(1):103112. doi: 10.1016/j.acap.2025.103112. Epub 2025 Jul 17. PMID- 40681983 OWN - NLM STAT- MEDLINE DCOM- 20250719 LR - 20250722 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Jul 18 TI - Relationship between sustainable food literacy, organic food consumption and climate change awareness and worry in Turkiye. PG - 2491 LID - 10.1186/s12889-025-22482-0 [doi] LID - 2491 AB - OBJECTIVE: The rapid increase in population, industrialization, and the rise in fossil fuel consumption have led to issues such as the depletion of natural resources, loss of biodiversity, and climate change, bringing the concept of sustainability to the forefront. This study aimed to examine the relationship between sustainable food literacy, organic food consumption, climate change awareness and worry. METHODS: This cross-sectional study included 1660 adults aged 18-65 years. Data were collected via a web-based survey that included demographic information, self-reported anthropometric measurements, and validated scales: Climate Change Awareness Scale, Climate Change Worry Scale, Organic Food Consumption Scale, and Sustainable Food Literacy Scale. RESULTS: The mean age of the participants was 29.3 +/- 12.07 years. A strong positive relationship was observed between the total score of the Climate Change Awareness Scale and the scores of the Climate Change Worry Scale, Organic Food Consumption Scale, and Sustainable Food Literacy Scale (r = 0.230, p < 0.001; r = 0.149, p < 0.001; r = 0.173, p < 0.001, respectively). According to linear regression analysis, it was determined that gender, education level, Climate Change Awareness Scale total score, Climate Change Worry Scale score, and Sustainable Food Literacy Scale score were correlated with the Organic Food Consumption Scale score (R(2)=0.527; p < 0.001). On the other hand, it was determined that gender, education level, income status, Climate Change Awareness Scale total score, Climate Change Anxiety Scale score and Organic Food Consumption Scale score were correlated with the Sustainable Food Literacy Scale score (R(2)=0.505; p < 0.001). It was determined that Climate Change Anxiety Scale score and the Sustainable Food Literacy Scale score were associated with the Climate Change Awareness Scale total score (R(2)=0.246; p < 0.001). In addition, it was determined that gender, marital status, Climate Change Awareness Scale total score, and Sustainable Food Literacy Scale score were associated with the Climate Change Worry Scale score (R(2)=0.286; p < 0.001). CONCLUSIONS: As a result, to combat global climate change, it is necessary to conduct further research in this field by considering these relationships, to identify and improve the factors influencing sustainable behaviors, to promote organic food consumption, and to assess awareness and anxiety regarding climate change. CI - (c) 2025. The Author(s). FAU - Mengi Celik, Ozge AU - Mengi Celik O AUID- ORCID: 0000-0002-0298-9591 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Faculty, University of Health Sciences, Ankara, Turkey. ozgeemengi@gmail.com. FAU - Akcakaya, Sena Dilsad AU - Akcakaya SD AUID- ORCID: 0000-0002-7971-0157 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkey. FAU - Ekici, Emine Merve AU - Ekici EM AUID- ORCID: 0000-0001-5409-6309 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Faculty, University of Health Sciences, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20250718 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Adult MH - Male MH - Female MH - Cross-Sectional Studies MH - *Climate Change MH - Middle Aged MH - Adolescent MH - Young Adult MH - Aged MH - Turkey MH - *Food, Organic/statistics & numerical data MH - Surveys and Questionnaires MH - *Health Literacy/statistics & numerical data MH - *Anxiety PMC - PMC12273353 OTO - NOTNLM OT - Climate change awareness OT - Climate change worry OT - Organic food consumption OT - Sustainable food literacy COIS- Declarations. Ethics approval and consent to participate: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was conducted with the approval of the University of Health Sciences Gulhane Scientific Research Ethics Committee, numbered 2024/543. Informed consent was obtained from all participants included in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/07/19 16:46 MHDA- 2025/07/19 16:47 PMCR- 2025/07/18 CRDT- 2025/07/18 23:40 PHST- 2025/02/04 00:00 [received] PHST- 2025/03/25 00:00 [accepted] PHST- 2025/07/19 16:47 [medline] PHST- 2025/07/19 16:46 [pubmed] PHST- 2025/07/18 23:40 [entrez] PHST- 2025/07/18 00:00 [pmc-release] AID - 10.1186/s12889-025-22482-0 [pii] AID - 22482 [pii] AID - 10.1186/s12889-025-22482-0 [doi] PST - epublish SO - BMC Public Health. 2025 Jul 18;25(1):2491. doi: 10.1186/s12889-025-22482-0. PMID- 40681739 OWN - NLM STAT- MEDLINE DCOM- 20250718 LR - 20260902 IS - 1573-8744 (Electronic) IS - 1567-567X (Print) IS - 1567-567X (Linking) VI - 52 IP - 4 DP - 2025 Jul 18 TI - Physiologically-based pharmacokinetic model for predicting drug-drug interactions perpetrated by posaconazole in healthy subjects with normal weight and obesity: Concomitant use and washout. PG - 39 LID - 10.1007/s10928-025-09983-6 [doi] LID - 39 AB - Posaconazole is an effective broad-spectrum triazole antifungal used as prophylaxis or to treat invasive Aspergillus and Candida infections in adults and pediatric patients. Posaconazole is a known strong inhibitor of cytochrome P4503A4 (CYP3A4) and substrate of P-glycoprotein (P-gp), which may lead to drug-drug interactions (DDIs) when co-administered with CYP3A4-sensitive substrates and warrants modified dosing of sensitive drugs when administered concomitantly with posaconazole. Given the long elimination half-life of posaconazole (26-35 h), there is the potential for DDIs caused by posaconazole after discontinuing the antifungal. Our clinical studies revealed that the half-life of posaconazole is significantly prolonged in subjects with a body mass index (BMI) >/= 35 kg/m(2), which may put this population at an increased risk of DDIs after stopping posaconazole. This manuscript describes the development, verification, and validation of a whole-body, physiologically-based pharmacokinetic (PBPK) model which describes the concomitant use and washout DDIs of posaconazole delayed-release tablet (DRT) with victim drugs ranolazine and lurasidone in healthy volunteers of normal weight and with obesity. The key findings of this model are 1) the half-life of posaconazole is significantly prolonged in patients with BMI >/= 35 kg/m(2) and 2) the mechanism of inhibition of CYP3A4 by posaconazole appears to be irreversible in vivo. This model may be used moving forward to assess the potential for washout DDIs with CYP3A4-sensitive substrates during concomitant use with, and after discontinuing posaconazole in subjects with normal weight and obesity. CI - (c) 2025. The Author(s). FAU - Bruno, Christopher D AU - Bruno CD AD - Emerald Lake Safety, Newport Beach, CA, USA. AD - Program in Pharmacology and Drug Development, Tufts University School of Medicine; and the Clinical and Translational Science Institute, Tufts Medical Center, Boston, MA, USA. FAU - Elmokadem, Ahmed AU - Elmokadem A AD - Metrum Research Group, Boston, MA, USA. FAU - Greenblatt, David J AU - Greenblatt DJ AD - Program in Pharmacology and Drug Development, Tufts University School of Medicine; and the Clinical and Translational Science Institute, Tufts Medical Center, Boston, MA, USA. FAU - Chow, Christina R AU - Chow CR AD - Emerald Lake Safety, Newport Beach, CA, USA. christina@elsafety.com. LA - eng GR - UM1 TR004398/TR/NCATS NIH HHS/United States GR - UM1TR004398/NH/NIH HHS/United States PT - Journal Article DEP - 20250718 PL - United States TA - J Pharmacokinet Pharmacodyn JT - Journal of pharmacokinetics and pharmacodynamics JID - 101096520 RN - 6TK1G07BHZ (posaconazole) RN - 0 (Triazoles) RN - 0 (Antifungal Agents) RN - EC 1.14.14.1 (Cytochrome P-450 CYP3A) RN - 0 (Cytochrome P-450 CYP3A Inhibitors) RN - EC 1.14.14.55 (CYP3A4 protein, human) SB - IM MH - Humans MH - *Triazoles/pharmacokinetics/administration & dosage MH - Drug Interactions/physiology MH - *Antifungal Agents/pharmacokinetics/administration & dosage MH - Adult MH - *Models, Biological MH - *Obesity/metabolism MH - Male MH - Female MH - Half-Life MH - Cytochrome P-450 CYP3A/metabolism MH - Cytochrome P-450 CYP3A Inhibitors/pharmacokinetics MH - Healthy Volunteers MH - Body Weight/physiology MH - Middle Aged MH - Young Adult MH - Body Mass Index PMC - PMC12274254 OTO - NOTNLM OT - Drug-drug interactions OT - Obesity OT - Physiologically-based pharmacokinetic modeling OT - Posaconazole COIS- Declarations. Competing interests: CDB and CRC are employees of Emerald Lake Safety, LLC. DJG is supported in part by grant UM1 TR004398 from the National Institutes of Health, Department of Health and Human Services. The BOW-001 and BOW-002 studies were funded by Emerald Lake Safety, LLC and followed ethical guidelines as described in the original study publications. EDAT- 2025/07/19 16:44 MHDA- 2025/07/19 16:45 PMCR- 2025/07/18 CRDT- 2025/07/18 23:31 PHST- 2025/01/28 00:00 [received] PHST- 2025/05/06 00:00 [accepted] PHST- 2025/07/19 16:45 [medline] PHST- 2025/07/19 16:44 [pubmed] PHST- 2025/07/18 23:31 [entrez] PHST- 2025/07/18 00:00 [pmc-release] AID - 10.1007/s10928-025-09983-6 [pii] AID - 9983 [pii] AID - 10.1007/s10928-025-09983-6 [doi] PST - epublish SO - J Pharmacokinet Pharmacodyn. 2025 Jul 18;52(4):39. doi: 10.1007/s10928-025-09983-6. PMID- 40681623 OWN - NLM STAT- MEDLINE DCOM- 20250718 LR - 20251017 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Jul 18 TI - Diet quality and food insecurity in Lebanon: insights into dietary diversity, mediterranean diet adherence, and phytochemical intake among adults. PG - 26092 LID - 10.1038/s41598-025-12013-7 [doi] LID - 26092 AB - Lebanon is undergoing a nutrition transition that increases the risk of nutritional deficiencies and noncommunicable diseases. This study assessed diet quality-measured by adherence to the Mediterranean diet (MD), household dietary diversity (HDD), and the dietary phytochemical index (DPI)-and examined its associations with sociodemographic factors and food insecurity (FI) among Lebanese adults. A cross-sectional survey was conducted from May to September 2022, involving a nationally representative sample of 444 adults aged 18-64 years. Participants were selected using a stratified cluster sampling technique across the eight Lebanese governorates. Data were collected through face-to-face anthropometric assessments and phone-based dietary and sociodemographic questionnaires. Dietary intake was assessed using a validated food frequency questionnaire (FFQ) and two non-consecutive 24-hour recalls. HDD was calculated using the Food Consumption Score (FCS), MD adherence was evaluated using the 14-MEDAS, and DPI was derived from the proportion of energy intake from phytochemical-rich foods. More than half of the participants (56.3%) had low HDD, 54.1% showed fair-to-very good adherence to the MD, and the mean DPI accounted for 22.25% of total energy intake. Being employed (aOR: 1.67; CI: 1.08-2.58) and having a university education (aOR: 3.29; CI: 1.95-5.54) predicted higher HDD, while FI reduced the odds (aOR: 0.42; CI: 0.27-0.65). FI (aOR: 1.63; CI: 1.11-2.38), female sex, and being unmarried were associated with greater MD adherence. Higher age, female sex, and being unmarried predicted a higher DPI, while household crowding reduced it. Findings reveal that Lebanese adults have low dietary diversity, moderate MD adherence, and low phytochemical intake. FI, sex, age, marital status, crowding, education, and employment significantly influenced diet quality. Notably, FI was associated with lower HDD but paradoxically with higher MD adherence. These results highlight the urgent need for systemic interventions to enhance diet quality and food security in Lebanon. CI - (c) 2025. The Author(s). FAU - Abboud, Myriam AU - Abboud M AD - College of Natural and Health Sciences, Zayed University, Dubai, 19282, United Arab Emirates. FAU - Khattar, Maroun AU - Khattar M AUID- ORCID: 0009-0005-7253-1630 AD - PHENOL Research Group (Public Health Nutrition Program Lebanon), Faculty of Public Health, Lebanese University, Beirut, Lebanon. FAU - Tzenios, Nikolaos AU - Tzenios N AD - Faculty of Public Health, Charisma University, London, EC1V 7QE, UK. ksmu@kgmu.com. FAU - Rizk, Rana AU - Rizk R AUID- ORCID: 0000-0002-8850-6502 AD - Department of Nutrition and Food Science, Lebanese American University, P.O. Box 36, Byblos, Lebanon. AD - Institut National de Sante Publique, d'Epidemiologie Clinique, et de Toxicologie (INSPECT-LB), Beirut, Lebanon. FAU - Hoteit, Maha AU - Hoteit M AD - PHENOL Research Group (Public Health Nutrition Program Lebanon), Faculty of Public Health, Lebanese University, Beirut, Lebanon. m.hoteit@ul.edu.lb. AD - Institut National de Sante Publique, d'Epidemiologie Clinique, et de Toxicologie (INSPECT-LB), Beirut, Lebanon. m.hoteit@ul.edu.lb. AD - Department of Primary Care and Population Health, University of Nicosia Medical School, P.O. Box 24005, Nicosia, Cyprus. m.hoteit@ul.edu.lb. LA - eng PT - Journal Article DEP - 20250718 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Phytochemicals) SB - IM MH - Humans MH - Adult MH - Lebanon MH - Female MH - Male MH - Middle Aged MH - *Diet, Mediterranean/statistics & numerical data MH - Cross-Sectional Studies MH - Adolescent MH - Young Adult MH - *Phytochemicals MH - *Food Insecurity MH - *Diet MH - Surveys and Questionnaires MH - Socioeconomic Factors PMC - PMC12274531 OTO - NOTNLM OT - Diet diversity OT - Diet quality OT - Food security OT - Lebanon OT - Mediterranean diet OT - Phytochemicals COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/07/19 16:45 MHDA- 2025/07/19 16:46 PMCR- 2025/07/18 CRDT- 2025/07/18 23:24 PHST- 2025/03/25 00:00 [received] PHST- 2025/07/14 00:00 [accepted] PHST- 2025/07/19 16:46 [medline] PHST- 2025/07/19 16:45 [pubmed] PHST- 2025/07/18 23:24 [entrez] PHST- 2025/07/18 00:00 [pmc-release] AID - 10.1038/s41598-025-12013-7 [pii] AID - 12013 [pii] AID - 10.1038/s41598-025-12013-7 [doi] PST - epublish SO - Sci Rep. 2025 Jul 18;15(1):26092. doi: 10.1038/s41598-025-12013-7. PMID- 40680561 OWN - NLM STAT- MEDLINE DCOM- 20251202 LR - 20251202 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 85 DP - 2025 Nov-Dec TI - Comic book for asthma control in children. PG - 30-38 LID - S0882-5963(25)00253-2 [pii] LID - 10.1016/j.pedn.2025.07.010 [doi] AB - PURPOSE: to develop and analyze evidence of validity of a comic book for self-care of children with asthma. METHODS: this is a methodological study carried out in three phases. The first phase consisted of an integrative literature review to map the main guidelines for children with asthma and comic book development. The second phase consisted of analysis of evidence of content validity by 17 experts in the comic book and a questionnaire for children to assess the comic book. The third phase consisted of the comic book analysis by children with asthma using the questionnaire validated in the previous phase. Inter-judge agreement analysis was performed by calculating the Content Validity Ratio (CVR), and the critical value for each phase and round was based on the number of evaluators. RESULTS: thirty-nine studies were identified in the review and seven topics were addressed in the comic book construction (knowledge of disease; prevention of crises; correct use of medications; physical activity; environmental control; behavior in case of worsening of symptoms; and recognition of symptoms). The comic book script was assessed by experts, requiring four rounds for it to reach the critical CVR determined. It was subsequently assessed by 30 children with asthma, reaching the critical CVR in the first round of assessment. CONCLUSIONS: the comic book achieved adequate evidence of validity after assessment by experts and children, and could be a tool in the health education process for children with asthma. CI - Published by Elsevier Inc. FAU - Barreto, Alessandra Rosa Biaggi AU - Barreto ARB AD - Master of Science at Escola Paulista de Enfermagem, Universidade Federal de Sao Paulo, Sao Paulo, Brazil. FAU - de Oliveira, Leticia Fernanda Tavares Sousa AU - de Oliveira LFTS AD - Master of Science at Escola Paulista de Enfermagem, Universidade Federal de Sao Paulo, Sao Paulo, Brazil. FAU - Silva, Renan Alves AU - Silva RA AD - Adjunct Professor at Universidade Federal de Campina Grande, Centro de Formacao de Professores - Cajazeiras (PB), Brazil. FAU - Belela, Aline Santacruz AU - Belela AS AD - Adjunct Professor at Escola Paulista de Enfermagem, Universidade Federal de Sao Paulo, Brazil. Electronic address: aline.belela@unifesp.br. FAU - Kusahara, Denise Miyuki AU - Kusahara DM AD - Adjunct Professor at Escola Paulista de Enfermagem, Universidade Federal de Sao Paulo, Brazil. Electronic address: dkusahara@unifesp.br. FAU - Santos, Vinicius Batista AU - Santos VB AD - Adjunct Professor at Escola Paulista de Enfermagem, Universidade Federal de Sao Paulo, Brazil. Electronic address: v.santos@unifesp.br. LA - eng PT - Journal Article PT - Review DEP - 20250717 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM MH - Humans MH - *Asthma/therapy/prevention & control MH - Child MH - *Self Care/methods MH - Male MH - Female MH - *Patient Education as Topic/methods MH - Books MH - Surveys and Questionnaires MH - Reproducibility of Results MH - Comic Books as Topic OTO - NOTNLM OT - Asthma OT - Health education OT - Pediatrics OT - Validation studies COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/07/19 16:46 MHDA- 2025/12/02 07:36 CRDT- 2025/07/18 18:08 PHST- 2025/02/19 00:00 [received] PHST- 2025/07/10 00:00 [revised] PHST- 2025/07/10 00:00 [accepted] PHST- 2025/12/02 07:36 [medline] PHST- 2025/07/19 16:46 [pubmed] PHST- 2025/07/18 18:08 [entrez] AID - S0882-5963(25)00253-2 [pii] AID - 10.1016/j.pedn.2025.07.010 [doi] PST - ppublish SO - J Pediatr Nurs. 2025 Nov-Dec;85:30-38. doi: 10.1016/j.pedn.2025.07.010. Epub 2025 Jul 17. PMID- 40679562 OWN - NLM STAT- MEDLINE DCOM- 20250718 LR - 20250916 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 184 IP - 8 DP - 2025 Jul 18 TI - An AI-assisted tool for automated growth monitoring in pediatric achondroplasia. PG - 490 LID - 10.1007/s00431-025-06321-3 [doi] LID - 490 AB - Growth assessment in achondroplasia requires disorder-specific growth charts incorporating sex- and age-specific values. Manual calculations are tedious and subject to error. We present an artificial intelligence (AI)-assisted tool that automates z-score calculations for pediatric patients with achondroplasia. The tool integrates European Lambda-Mu-Sigma (LMS) growth reference data for 9 anthropometric parameters: height, weight, body mass index, head circumference, sitting height, leg length, arm span, relative sitting height, and foot length. It inputs anthropometric measurements and transforms them into sex- and age-specific z-scores and percentiles in real time. Ten pediatric endocrinologists independently calculated anthropometric z-scores for 3 patients with achondroplasia using both the manual growth charts and the automated tool. Time-to-completion and accuracy were recorded and compared. The mean time required by the AI-assisted tool to calculate z-scores for all 9 parameters was significantly shorter than that required by manual calculation (23.4 +/- 5.8 vs. 10.1 +/- 2.8 min, p < 0.001). The tool demonstrated 100% agreement with manual LMS-based calculations and eliminated human errors to which manual calculations are subject, with significantly higher median absolute z-score deviation compared to the smart tool (0.17 [0.07-0.30] vs. 0 [0-0.01], p < 0.001). CONCLUSION: This AI-assisted tool provides a user-friendly, accessible, and highly accurate method for automated growth assessment in pediatric achondroplasia. It facilitates efficient clinical and research applications, with potential for future integration into electronic health records and web-based platforms. WHAT IS KNOWN: *Growth monitoring in achondroplasia requires syndrome-specific Lambda-Mu-Sigma based charts. *Manual z-score calculations are time-consuming and subject to error. WHAT IS NEW: *We present an AI-assisted Excel tool that automates z-scores and percentile calculations for 9 anthropometric parameters. *Performance and inter-user reliability testing by 10 pediatric endocrinologists showed significantly improved speed and accuracy over manual methods. CI - (c) 2025. The Author(s). FAU - Cohen-Sela, Eyal AU - Cohen-Sela E AUID- ORCID: 0009-0008-0083-9443 AD - The Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, 64239-06, Tel Aviv, Israel. AD - The School of Medicine, Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Lebenthal, Yael AU - Lebenthal Y AUID- ORCID: 0000-0001-5963-0574 AD - The Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, 64239-06, Tel Aviv, Israel. yaelleb@tlvmc.gov.il. AD - The School of Medicine, Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. yaelleb@tlvmc.gov.il. FAU - Brener, Avivit AU - Brener A AUID- ORCID: 0000-0002-2742-8264 AD - The Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, 64239-06, Tel Aviv, Israel. AD - The School of Medicine, Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Regev, Ravit AU - Regev R AUID- ORCID: 0000-0002-0846-733X AD - The Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, 64239-06, Tel Aviv, Israel. AD - The School of Medicine, Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Hagenas, Lars AU - Hagenas L AUID- ORCID: 0000-0002-5605-2462 AD - Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden. LA - eng PT - Journal Article DEP - 20250718 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Achondroplasia/physiopathology/diagnosis MH - Male MH - Female MH - Child MH - *Growth Charts MH - *Artificial Intelligence MH - Child, Preschool MH - *Anthropometry/methods MH - Adolescent MH - Reproducibility of Results PMC - PMC12274215 OTO - NOTNLM OT - Z-scores OT - Achondroplasia OT - Anthropometric measurements OT - Artificial intelligence (AI) OT - Electronic growth charts OT - Growth assessment COIS- Declarations. Ethics and consent to participate: This study did not involve human participants or specific patient data, and therefore did not require informed consent. The research was conducted using publicly available reference datasets in accordance with ethical guidelines and best scientific practices. Competing interests: The authors declare no competing interests. EDAT- 2025/07/18 12:31 MHDA- 2025/07/18 12:32 PMCR- 2025/07/18 CRDT- 2025/07/18 11:06 PHST- 2025/05/01 00:00 [received] PHST- 2025/07/04 00:00 [accepted] PHST- 2025/06/13 00:00 [revised] PHST- 2025/07/18 12:32 [medline] PHST- 2025/07/18 12:31 [pubmed] PHST- 2025/07/18 11:06 [entrez] PHST- 2025/07/18 00:00 [pmc-release] AID - 10.1007/s00431-025-06321-3 [pii] AID - 6321 [pii] AID - 10.1007/s00431-025-06321-3 [doi] PST - epublish SO - Eur J Pediatr. 2025 Jul 18;184(8):490. doi: 10.1007/s00431-025-06321-3. PMID- 40677586 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250720 IS - 2950-5410 (Electronic) IS - 2950-5410 (Linking) VI - 17 DP - 2025 Sep TI - Development of Benign Enlargement of Subarachnoid Spaces Growth Charts. PG - 200157 LID - 10.1016/j.jpedcp.2025.200157 [doi] LID - 200157 AB - BACKGROUND: This study aimed to develop head circumference (HC) growth charts specific to infants and young children diagnosed with benign enlargement of the subarachnoid spaces. By modeling HC trajectories, we sought to establish normative curves that distinguish benign macrocephaly from pathologic causes of head enlargement. Our objective was to support accurate monitoring, reduce unnecessary imaging, and guide appropriate referral decisions in pediatric patients with macrocephaly. STUDY DESIGN: A retrospective analysis of HC measurements was conducted using data from 137 patients aged 0-6 years diagnosed with benign macrocephaly at the Children's Hospital of Eastern Ontario. Generalized Additive Models for Location, Scale, and Shape were employed to create growth charts. RESULTS: The study included 137 children with neuroimaging confirming benign macrocephaly diagnoses. Exclusion criteria were applied to ensure the cohort was representative of isolated benign macrocephaly cases. Benign macrocephalic percentile charts for HC were generated, showing accelerated early growth followed by stabilization around ages 2-3. For both boys and girls, the 50th centile tracks consistently above the 97th in World Health Organization data for non-benign macrocephalic patients. The majority of benign macrocephalic patients fell above the 97.5th percentile of the World Health Organization reference curves. We identified pathological growth by examining HCs greater than 60 cm and assessing for rapidly progressive HC growth patterns that required surgical intervention. CONCLUSIONS: We provide novel benign macrocephaly growth charts that enable accurate monitoring of HC in clinical settings. Furthermore, the use of these curves may help differentiate patients with benign macrocephaly from other entities that may warrant surgical intervention such as hydrocephalus. Future research should validate these findings in multicenter prospective studies for practitioners to remain abreast in clinical management strategies for infants with benign macrocephaly. CI - (c) 2025 The Author(s). FAU - Bitonti, Talia Mia AU - Bitonti TM AD - The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada. AD - Division of Neurosurgery, Department of Surgery, CHEO, University of Ottawa, Ottawa, ON, Canada. FAU - Chahrour, Mohamad AU - Chahrour M AD - The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada. FAU - Chee, Sharini Sam AU - Chee SS AD - Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. FAU - Burhunduli, Patricia AU - Burhunduli P AD - University of Ottawa, Faculty of Medicine, Ottawa, ON, Canada. FAU - Tu, Albert AU - Tu A AD - Division of Neurosurgery, Department of Surgery, CHEO, University of Ottawa, Ottawa, ON, Canada. LA - eng PT - Journal Article DEP - 20250613 PL - United States TA - J Pediatr Clin Pract JT - Journal of pediatrics. Clinical practice JID - 9918769578606676 PMC - PMC12270049 OTO - NOTNLM OT - BESS OT - benign enlargement of subarachnoid spaces OT - growth charts OT - macrocephaly OT - pediatric neurosurgery OT - pediatrics COIS- The authors do not have any conflicts of interest to disclose. No funding was used for this study. EDAT- 2025/07/18 06:25 MHDA- 2025/07/18 06:26 PMCR- 2025/06/13 CRDT- 2025/07/18 05:17 PHST- 2025/02/07 00:00 [received] PHST- 2025/05/24 00:00 [revised] PHST- 2025/06/10 00:00 [accepted] PHST- 2025/07/18 06:26 [medline] PHST- 2025/07/18 06:25 [pubmed] PHST- 2025/07/18 05:17 [entrez] PHST- 2025/06/13 00:00 [pmc-release] AID - S2950-5410(25)00019-5 [pii] AID - 200157 [pii] AID - 10.1016/j.jpedcp.2025.200157 [doi] PST - epublish SO - J Pediatr Clin Pract. 2025 Jun 13;17:200157. doi: 10.1016/j.jpedcp.2025.200157. eCollection 2025 Sep. PMID- 40677491 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250720 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 17 IP - 6 DP - 2025 Jun TI - Assessment and Referral of Patients With Short Stature at Primary Care Buraidah, Saudi Arabia. PG - e86197 LID - 10.7759/cureus.86197 [doi] LID - e86197 AB - BACKGROUND AND OBJECTIVES: Short stature (SS) causes a significant social and mental burden on patients and their families. Primary healthcare (PHC) physicians (Family Medicine) are crucial in securing the timely evaluation and referral of children with SS. This research aimed to assess the management and referral of short-stature patients by PHC physicians about SS in Buraidah, Saudi Arabia. METHODS: A cross-sectional study was conducted among PHC physicians in Buraidah from November 2024 to February 2025. A validated closed-ended questionnaire was used to collect data online. Descriptive and inferential analyses were carried out to assess knowledge levels, attitudes, practices, and factors influencing their knowledge of SS. Data was analyzed using the Statistical Package for Social Sciences (SPSS). RESULTS: A total of 143 PHC physicians participated in the study. Mean knowledge score (standard deviation) was 7.0 (+/-2.47) out of 13. About 99 (69%) would refer a patient once the height falls below the 5th percentile. More than half, 79 (55%), considered growth hormone as an option for the treatment of SS. Seventy-two percent used local growth charts. The most common tests requested before referral of SS patients were complete blood count (CBC) 110 (77%) and thyroid function test 109 (76%). The majority (79% to 98.6%) of participant indicated their learning needs on various aspects of SS. There was no significant difference in the knowledge score with respect to socio-demographic and professional characteristics except for nationality. CONCLUSION: Knowledge level of PHC physicians in Buraidah is moderate (68%), with the majority indicating their learning needs on this topic. The study's findings call for focused educational initiatives and policy enhancements to advance healthcare delivery for children with SS in Buraidah, Saudi Arabia. CI - Copyright (c) 2025, Almutairi et al. FAU - Almutairi, Futun AU - Almutairi F AD - Family Medicine Academy, Qassim Health Cluster, Buraydah, SAU. FAU - Rabbani, Unaib AU - Rabbani U AD - Family Medicine Academy, Qassim Health Cluster, Buraydah, SAU. LA - eng PT - Journal Article DEP - 20250617 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC12268960 OTO - NOTNLM OT - growth hormone OT - kingdom of saudi arabia (ksa) OT - management OT - primary care OT - short stature COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Qassim Regional Bioethics Committee issued approval 607/46/3012. Ethical approval was obtained from the Qassim Regional Bioethics Committee. Informed consent was obtained from all study participants before their participation. Participation was voluntary, and participants had the right to withdraw from the study at any time without any consequences. Furthermore, data was anonymous without the use of personal identifiers. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2025/07/18 06:26 MHDA- 2025/07/18 06:27 PMCR- 2025/06/17 CRDT- 2025/07/18 05:16 PHST- 2025/06/16 00:00 [accepted] PHST- 2025/07/18 06:27 [medline] PHST- 2025/07/18 06:26 [pubmed] PHST- 2025/07/18 05:16 [entrez] PHST- 2025/06/17 00:00 [pmc-release] AID - 10.7759/cureus.86197 [doi] PST - epublish SO - Cureus. 2025 Jun 17;17(6):e86197. doi: 10.7759/cureus.86197. eCollection 2025 Jun. PMID- 40675635 OWN - NLM STAT- MEDLINE DCOM- 20250717 LR - 20250804 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 7 DP - 2025 Jul 17 TI - Measurement of critical health literacy in primary school pupils: a Polish validation of the Claim Evaluation Tools. PG - e099994 LID - 10.1136/bmjopen-2025-099994 [doi] LID - e099994 AB - OBJECTIVES: Amid increasing adolescents' immersion in media information and their vulnerability to mis/disinformation and the screen time negative health correlates, competences of critical thinking about health gains in significance. The Claim Evaluation Tools (CET) assess the understanding of claims about treatment effects and enable critical health literacy measurement in different populations. It has not been adapted and tested in Central Europe before. DESIGN: The process of cultural adaptation covered three phases: translation and cultural adaptation, testing and psychometric analysis. We used Classical Test Theory and Rasch analysis to verify the validity and reliability of the Polish version of the CET. Additionally, we tested known-group and convergent validity. SETTING: The pilot test was conducted on a pupils sample from eight purposefully selected schools in Southern Poland, and the final version of the tool has been tested on a national study sample of pupils of primary schools randomly selected from all Polish regions. PARTICIPANTS: We collected the data from a national sample of 2242 pupils aged 12 to 15 years, attending sixth to eighth grades, from 42 primary schools. RESULTS: We applied some changes to the multiple-choice questions (MCQ) scenarios and wording of some of the options based on the expert's opinions. We validated 24 MCQs reflecting 12 claims about treatment effects (2 MCQs per claim). The psychometric properties of the Polish version of the tool are satisfying. CONCLUSIONS: The Polish version of the CET can be applied to measure critical health literacy among 12- to 15-year-old adolescents as well as to evaluate educational interventions promoting the understanding of healthcare claims in Poland. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY. Published by BMJ Group. FAU - Prokop-Dorner, Anna AU - Prokop-Dorner A AUID- ORCID: 0000-0003-3575-469X AD - Department of Medical Sociology, Chair of Epidemiology and Preventive Medicine, Jagiellonian University Medical College, Krakow, Poland anna.prokop@uj.edu.pl. FAU - Zawisza, Katarzyna AU - Zawisza K AD - Department of Medical Sociology, Chair of Epidemiology and Preventive Medicine, Jagiellonian University Medical College, Krakow, Poland. FAU - Swiatkiewicz-Mosny, Maria AU - Swiatkiewicz-Mosny M AUID- ORCID: 0000-0001-6797-5580 AD - Institute of Sociology, Jagiellonian University, Krakow, Poland. FAU - Kobla-Pilat, Aleksandra AU - Kobla-Pilat A AD - Department of Medical Sociology, Chair of Epidemiology and Preventive Medicine, Jagiellonian University Medical College, Krakow, Poland. FAU - Ozegalska-Lukasik, Natalia AU - Ozegalska-Lukasik N AUID- ORCID: 0000-0002-4239-4429 AD - Institute of Intercultural Studies, Jagiellonian University, Krakow, Poland. FAU - Slusarczyk, Magdalena AU - Slusarczyk M AD - Institute of Sociology, Jagiellonian University, Krakow, Poland. FAU - Potysz-Rzyman, Aleksandra AU - Potysz-Rzyman A AD - Institute of Sociology, Jagiellonian University, Krakow, Poland. FAU - M Bala, Malgorzata AU - M Bala M AUID- ORCID: 0000-0003-1978-7264 AD - Department of Hygiene and Dietetics, Chair of Epidemiology and Preventive Medicine, Jagiellonian University Medical College, Krakow, Poland. LA - eng PT - Journal Article PT - Validation Study DEP - 20250717 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Poland MH - *Health Literacy MH - Adolescent MH - Male MH - Female MH - Child MH - Psychometrics MH - Reproducibility of Results MH - Schools MH - *Students MH - Surveys and Questionnaires/standards MH - Pilot Projects PMC - PMC12273065 OTO - NOTNLM OT - Adolescents OT - Health Education OT - Health Literacy COIS- Competing interests: None declared. EDAT- 2025/07/18 01:39 MHDA- 2025/07/18 01:40 PMCR- 2025/07/17 CRDT- 2025/07/17 20:43 PHST- 2025/07/18 01:40 [medline] PHST- 2025/07/18 01:39 [pubmed] PHST- 2025/07/17 20:43 [entrez] PHST- 2025/07/17 00:00 [pmc-release] AID - bmjopen-2025-099994 [pii] AID - 10.1136/bmjopen-2025-099994 [doi] PST - epublish SO - BMJ Open. 2025 Jul 17;15(7):e099994. doi: 10.1136/bmjopen-2025-099994. PMID- 40673697 OWN - NLM STAT- MEDLINE DCOM- 20250717 LR - 20260913 IS - 1096-9071 (Electronic) IS - 0146-6615 (Print) IS - 0146-6615 (Linking) VI - 97 IP - 7 DP - 2025 Jul TI - Increase in HEV IgG Seroprevalence During the Past Years in Southern France. PG - e70483 LID - 10.1002/jmv.70483 [doi] LID - e70483 AB - The sources and routes of HEV infections in industrialized countries are not fully defined. Occitanie in Southern France is an hyperendemic area but the relative extent of contaminated food and water consumption is unknown. We used validated assays to determine IgG and IgM seroprevalence among 3480 French blood donors living in Occitanie and compared the data with those obtained about twelve years ago. Epidemiological information was collected using a specific questionnaire. HEV IgG seroprevalence increased from 39.1% in 2011% to 47.8% in 2023. Unlike 12 years ago, the wastewater treatment method and tap water consumption were linked to HEV infection. Consumption of bottled water is now a risk factor for HEV infection. Overall IgM seroprevalence was 1.3%. The high prevalence of anti-HEV IgG in Occitanie cannot be explained by eating habits alone. Water consumption and treatment also appear to be important factors of HEV infections in Southern France. CI - (c) 2025 The Author(s). Journal of Medical Virology published by Wiley Periodicals LLC. FAU - Dimeglio, Chloe AU - Dimeglio C AUID- ORCID: 0000-0002-3713-4913 AD - Laboratory of Virology, National Reference Center on HEV, Institut Federatif de Biologie, Toulouse University Hospital, Toulouse, France. AD - INSERM UMR 1291, Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), Toulouse, France. FAU - El Rakaawi, Mohamed AU - El Rakaawi M AD - Etablissement Francais Du Sang, Toulouse, France. FAU - Boineau, Jerome AU - Boineau J AD - Laboratory of Virology, National Reference Center on HEV, Institut Federatif de Biologie, Toulouse University Hospital, Toulouse, France. FAU - De Smet, Clementine AU - De Smet C AD - Laboratory of Virology, National Reference Center on HEV, Institut Federatif de Biologie, Toulouse University Hospital, Toulouse, France. FAU - Abravanel, Florence AU - Abravanel F AUID- ORCID: 0000-0002-1753-1065 AD - Laboratory of Virology, National Reference Center on HEV, Institut Federatif de Biologie, Toulouse University Hospital, Toulouse, France. AD - INSERM UMR 1291, Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), Toulouse, France. FAU - Lhomme, Sebastien AU - Lhomme S AUID- ORCID: 0000-0001-7908-1576 AD - Laboratory of Virology, National Reference Center on HEV, Institut Federatif de Biologie, Toulouse University Hospital, Toulouse, France. AD - INSERM UMR 1291, Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), Toulouse, France. FAU - Bardiaux, Laurent AU - Bardiaux L AD - Etablissement Francais Du Sang, Toulouse, France. FAU - Izopet, Jacques AU - Izopet J AD - Laboratory of Virology, National Reference Center on HEV, Institut Federatif de Biologie, Toulouse University Hospital, Toulouse, France. AD - INSERM UMR 1291, Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), Toulouse, France. LA - eng PT - Journal Article PL - United States TA - J Med Virol JT - Journal of medical virology JID - 7705876 RN - 0 (Immunoglobulin G) RN - 0 (Immunoglobulin M) RN - 0 (Hepatitis Antibodies) SB - IM MH - Humans MH - France/epidemiology MH - *Hepatitis E/epidemiology/immunology MH - Seroepidemiologic Studies MH - *Immunoglobulin G/blood MH - Male MH - Female MH - Adult MH - Middle Aged MH - Immunoglobulin M/blood MH - Young Adult MH - *Hepatitis E virus/immunology MH - *Hepatitis Antibodies/blood MH - Adolescent MH - Blood Donors MH - Risk Factors MH - Surveys and Questionnaires MH - Aged PMC - PMC12269536 OTO - NOTNLM OT - HEV OT - epidemiology OT - risk factors OT - seroprevalence OT - water COIS- The authors declare no conflicts of interest. EDAT- 2025/07/17 12:30 MHDA- 2025/07/17 12:31 PMCR- 2025/07/17 CRDT- 2025/07/17 09:13 PHST- 2025/05/26 00:00 [revised] PHST- 2025/03/08 00:00 [received] PHST- 2025/06/22 00:00 [accepted] PHST- 2025/07/17 12:31 [medline] PHST- 2025/07/17 12:30 [pubmed] PHST- 2025/07/17 09:13 [entrez] PHST- 2025/07/17 00:00 [pmc-release] AID - JMV70483 [pii] AID - 10.1002/jmv.70483 [doi] PST - ppublish SO - J Med Virol. 2025 Jul;97(7):e70483. doi: 10.1002/jmv.70483. PMID- 40671625 OWN - NLM STAT- MEDLINE DCOM- 20250923 LR - 20260825 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 21 IP - 4 DP - 2025 Oct TI - Adherence to the Lebanese National Dietary and Lifestyle Guidelines for Pregnancy and Its Association With Postpartum Weight Retention. PG - e70070 LID - 10.1111/mcn.70070 [doi] LID - e70070 AB - The Lebanese National Dietary and Lifestyle Guidelines for Pregnancy (DLGP) were developed to foster maternal and child health. The study aims to examine adherence to the DLGP and investigate its association with postpartum weight retention at 6 months (PPWR6). This study is based on the Mother and Infant Nutrition Assessment prospective cohort study conducted among pregnant women in Lebanon (n = 152). Pregnant women were recruited during their first trimester and were followed up until 6 months after delivery. Data on the socio-economic, anthropometric and lifestyle characteristics of participants were collected. A validated FFQ was used to examine dietary intake during the second trimester. A composite score was calculated for the adherence to the DLGP, with high adherence defined as belonging to the third tertile of the score. PPWR6 was calculated as the difference between pre-pregnancy weight and weight at 6 months postpartum, and high PPWR6 was defined as belonging to the third tertile of PPWR6 (>/= 5.4 kg). Multiple logistic regression was used to examine associations between adherence to guidelines and PPWR6. The proportion of participants adhering was lowest for guidelines regarding saturated fats (1.3%), sugar (13.8%), hydration (21.7%), adequate gestational weight gain (37.5%), omega-3 supplementation (38.8%) and salt (44.1%). Average PPWR6 was 3.9 kg, with 34.2% of participants retaining >/= 5 kg. While no association was observed between any of the individual guidelines with PPWR6, participants with high adherence to the DLGP had 77% lower odds of a PPWR6 more than 5.4 kg, compared to those in the first and second tertiles (adjusted OR: 0.23, 95% CI: 0.09, 0.58). The findings of this study highlighted important gaps in adherence to the DLGP, along with a direct association between higher DLGP adherence and lower PPWR. These findings underscore the need for comprehensive strategies to promote healthier practices during pregnancy and mitigate long-term risks of obesity and related chronic diseases. CI - (c) 2025 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Chokor, Fatima Al Zahraa AU - Chokor FAZ AUID- ORCID: 0000-0002-0418-7146 AD - Department of Health Promotion, Maastricht University/CAPHRI, Maastricht, the Netherlands. AD - Department of Public Health, College of Health Sciences, QU Health, Qatar University, Doha, Qatar. FAU - Eussen, Simone J P M AU - Eussen SJPM AD - Department of Epidemiology, Maastricht University, Maastricht, the Netherlands. AD - CARIM Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands. AD - CAPHRI Care and Public Health Maastricht, Maastricht University, Maastricht, the Netherlands. FAU - Crone, Matty AU - Crone M AD - Department of Health Promotion, Maastricht University/CAPHRI/NUTRIM, Maastricht, the Netherlands. FAU - Abdulmalik, Mariam AU - Abdulmalik M AD - Primary Health Care Corporation, Doha, Qatar. FAU - Ayoub, Jennifer AU - Ayoub J AD - Faculty of Agriculture and Food Sciences, American University of Beirut, Beirut, Lebanon. FAU - Zgheib, Pamela AU - Zgheib P AD - Mother, Child and School Health Unit, Ministry of Public Health, Beirut, Lebanon. FAU - Chatila, Aya AU - Chatila A AD - Faculty of Agriculture and Food Sciences, American University of Beirut, Beirut, Lebanon. FAU - Nasreddine, Lara AU - Nasreddine L AUID- ORCID: 0000-0003-3707-8218 AD - Faculty of Agriculture and Food Sciences, American University of Beirut, Beirut, Lebanon. FAU - Naja, Farah AU - Naja F AD - Department of Clinical Nutrition and Dietetics, College of Health Sciences, Research Institute of Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah, United Arab Emirates. AD - Nutrition and Food Sciences Department, American University of Beirut, Beirut, Lebanon. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250717 PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Adult MH - Lebanon MH - *Postpartum Period/physiology MH - *Nutrition Policy MH - Prospective Studies MH - *Life Style MH - *Diet MH - Young Adult MH - Gestational Weight Gain MH - *Patient Compliance/statistics & numerical data MH - Maternal Nutritional Physiological Phenomena MH - Weight Gain PMC - PMC12454199 OTO - NOTNLM OT - Lebanon OT - adherence OT - cohort OT - dietary guidelines OT - postpartum weight retention OT - pregnant women COIS- The authors declare no conflicts of interest. EDAT- 2025/07/17 06:27 MHDA- 2025/09/23 06:38 PMCR- 2025/07/17 CRDT- 2025/07/17 04:43 PHST- 2025/05/25 00:00 [revised] PHST- 2025/02/28 00:00 [received] PHST- 2025/06/25 00:00 [accepted] PHST- 2025/09/23 06:38 [medline] PHST- 2025/07/17 06:27 [pubmed] PHST- 2025/07/17 04:43 [entrez] PHST- 2025/07/17 00:00 [pmc-release] AID - MCN70070 [pii] AID - 10.1111/mcn.70070 [doi] PST - ppublish SO - Matern Child Nutr. 2025 Oct;21(4):e70070. doi: 10.1111/mcn.70070. Epub 2025 Jul 17. PMID- 40671317 OWN - NLM STAT- MEDLINE DCOM- 20251103 LR - 20251103 IS - 1365-263X (Electronic) IS - 0960-7439 (Linking) VI - 35 IP - 6 DP - 2025 Nov TI - FAIREST-6 as a Screening Tool for Sleep-Disordered Breathing, Orthodontic Needs, and BMI in Children During the Mixed Dentition Period. PG - 1153-1161 LID - 10.1111/ipd.70017 [doi] AB - BACKGROUND: Sleep-disordered breathing (SDB) in children is a growing health concern, with dentists playing a key role in early detection. AIM: This cross-sectional study evaluates the FAIREST-6 screening tool for identifying SDB and associated orofacial dysfunctions during mixed dentition and examines its relationship with orthodontic parameters and body mass index (BMI). DESIGN: The study included 100 children from Marmara University. SDB was assessed using the Sleep Disturbance Scale for Children (SDSC), while FAIREST-6, the Index of Orthodontic Treatment Need (IOTN), and Angle's classification were used for clinical evaluations. BMI was calculated, and statistical analyses were performed with SPSS. RESULTS: FAIREST-6 scores were significantly associated with SDB (p < 0.001) but not with IOTN (p = 0.053). However, IOTN scores correlated with SDSC (p = 0.033), suggesting a link between malocclusion severity and sleep disturbances. BMI varied significantly across FAIREST-6 scores (p = 0.002), indicating a relationship between obesity and airway issues. No significant differences were found based on gender or age (p > 0.050). CONCLUSION: FAIREST-6 shows potential as a screening tool for SDB and related orofacial dysfunctions in children. Further research is needed to validate its clinical use and explore its role in assessing SDB, malocclusion, and BMI. CI - (c) 2025 BSPD, IAPD and John Wiley & Sons Ltd. FAU - Torun, Cagla Kondoz AU - Torun CK AUID- ORCID: 0009-0008-6789-5124 AD - Marmara University Faculty of Dentistry, Department of Pediatric Dentistry, Istanbul, Turkey. FAU - Durmus, Basak AU - Durmus B AUID- ORCID: 0000-0002-5870-0021 AD - Marmara University Faculty of Dentistry, Department of Pediatric Dentistry, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20250716 PL - England TA - Int J Paediatr Dent JT - International journal of paediatric dentistry JID - 9107511 SB - IM MH - Humans MH - *Body Mass Index MH - Male MH - *Sleep Apnea Syndromes/diagnosis MH - Female MH - Child MH - Cross-Sectional Studies MH - *Dentition, Mixed MH - *Index of Orthodontic Treatment Need MH - *Mass Screening/methods MH - *Malocclusion/diagnosis OTO - NOTNLM OT - body mass index OT - malocclusion OT - orofacial dysfunction OT - sleep OT - sleep apnea syndromes EDAT- 2025/07/17 06:27 MHDA- 2025/11/03 06:27 CRDT- 2025/07/17 01:43 PHST- 2025/04/30 00:00 [revised] PHST- 2025/02/27 00:00 [received] PHST- 2025/07/07 00:00 [accepted] PHST- 2025/11/03 06:27 [medline] PHST- 2025/07/17 06:27 [pubmed] PHST- 2025/07/17 01:43 [entrez] AID - 10.1111/ipd.70017 [doi] PST - ppublish SO - Int J Paediatr Dent. 2025 Nov;35(6):1153-1161. doi: 10.1111/ipd.70017. Epub 2025 Jul 16. PMID- 40670953 OWN - NLM STAT- MEDLINE DCOM- 20250717 LR - 20250721 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 25 IP - 1 DP - 2025 Jul 16 TI - Exploring the link between screen time and severity of early childhood caries in primary molars: a cross-sectional study. PG - 1181 LID - 10.1186/s12903-025-06135-7 [doi] LID - 1181 AB - BACKGROUND: Early Childhood Caries (ECC) is a significant yet often overlooked paediatric health concern, particularly in India. Previous studies have linked excessive screen exposure, known as Problematic Screen Exposure (PSE), with caries in children. However, the association between PSE and the severity of ECC in terms of cavitated and non-cavitated lesions remains unexplored. This study investigates the prevalence of PSE among ECC-affected preschool children and examines its correlation with ECC severity. METHODS: A cross-sectional observational study was conducted among 100 children aged 36-71 months diagnosed with ECC. Data on screen exposure were collected using the "Seven-in-Seven Screen Exposure Questionnaire," validated per American Academy of Paediatrics guidelines. Clinical examinations classified caries severity using the International Caries Detection and Assessment System (ICDAS-II). Statistical analyses, including the Mann-Whitney U test and Spearman's correlation, assessed relationships between PSE, sociodemographic factors, and ECC severity. RESULTS: 57% of participants exhibited high PSE scores. A majority of children (75%) had cavitated lesions. High PSE was associated with higher mean ICDAS scores for molars (p = 0.025), although the correlation between PSE and ECC severity was very weak and not statistically significant (r = 0.042, p = 0.680). Sociodemographic factors, including family size and parental education, were also analysed, with families having three or more children showing elevated ICDAS scores. Oral hygiene practices and dietary habits partially influenced caries severity, with children using non-fluoridated toothpaste exhibiting higher ICDAS scores. CONCLUSIONS: High PSE may contribute to the progression of ECC, as evidenced by a higher prevalence of cavitated lesions among children with elevated PSE scores. Preventive strategies focusing on reducing PSE and promoting healthy oral hygiene practices may mitigate ECC severity. Further longitudinal studies are necessary to establish causality and inform targeted prevention strategies. CI - (c) 2025. The Author(s). FAU - Kalaivanan, Dhanraj AU - Kalaivanan D AD - Department of Paediatric and Preventive Dentistry, Sathyabama Dental College and Hospital, Chennai, India. drdhanraj.dental@sathyabama.ac.in. FAU - Lakshmanan, Meenakshi AU - Lakshmanan M AD - Department of Paediatric and Preventive Dentistry, Sathyabama Dental College and Hospital, Chennai, India. FAU - Das, Meghana AU - Das M AD - Department of Paediatric and Preventive Dentistry, Sathyabama Dental College and Hospital, Chennai, India. FAU - Saleem, Sumaiyya AU - Saleem S AD - Department of Paediatric and Preventive Dentistry, Sathyabama Dental College and Hospital, Chennai, India. FAU - Akr, Santhosh Priya AU - Akr SP AD - Department of Paediatric and Preventive Dentistry, Sathyabama Dental College and Hospital, Chennai, India. FAU - Chamarthi, Vishnu Rekha AU - Chamarthi VR AD - Department of Paediatric and Preventive Dentistry, Sathyabama Dental College and Hospital, Chennai, India. LA - eng PT - Journal Article PT - Observational Study DEP - 20250716 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - *Dental Caries/epidemiology/etiology/pathology MH - Cross-Sectional Studies MH - Child, Preschool MH - Male MH - Female MH - India/epidemiology MH - *Tooth, Deciduous/pathology MH - Severity of Illness Index MH - *Screen Time MH - *Molar/pathology MH - Child MH - Prevalence PMC - PMC12269225 COIS- Declarations. Ethics approval and consent to participate: The research protocol was approved by the Ethics Committee of Sathyabama Institute of Science and Technology (Protocol Approval Code: 366-IRB-IBSEC/SIST; dated April 16,2024) The study was conducted ethically following the World Medical Association Declaration of Helsinki. * Informed consent was obtained from the parent and/or legal guardian for all study participants prior to data collection and clinical examination. Only children with a signed parental consent who also provided verbal assent were included in the study. The rights of all subjects were protected, and all data were kept confidential. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/07/17 04:42 MHDA- 2025/07/17 06:27 PMCR- 2025/07/16 CRDT- 2025/07/16 23:46 PHST- 2025/02/01 00:00 [received] PHST- 2025/05/08 00:00 [accepted] PHST- 2025/07/17 06:27 [medline] PHST- 2025/07/17 04:42 [pubmed] PHST- 2025/07/16 23:46 [entrez] PHST- 2025/07/16 00:00 [pmc-release] AID - 10.1186/s12903-025-06135-7 [pii] AID - 6135 [pii] AID - 10.1186/s12903-025-06135-7 [doi] PST - epublish SO - BMC Oral Health. 2025 Jul 16;25(1):1181. doi: 10.1186/s12903-025-06135-7. PMID- 40670646 OWN - NLM STAT- MEDLINE DCOM- 20250925 LR - 20251114 IS - 1476-5497 (Electronic) IS - 0307-0565 (Print) IS - 0307-0565 (Linking) VI - 49 IP - 9 DP - 2025 Sep TI - Classification of childhood obesity using longitudinal clinical body mass index and its validation. PG - 1864-1873 LID - 10.1038/s41366-025-01836-z [doi] AB - OBJECTIVE: Persistence of childhood adiposity is known to be associated with long-term adverse cardiometabolic risks. Yet, cross-sectional body mass index (BMI) is often used to classify obesity in clinical care and research. This study aimed to develop and validate a childhood BMI classification system using real life longitudinal clinical data. METHODS: This observational study used electronic health record data from a tertiary care hospital, with replication in an independent cohort. For individuals with >/= 3 BMI measurements, the median BMI percentile and persistence in the obesity class were used for longitudinal classification. The association between longitudinal BMI class and early onset obesity, socioeconomic status (SES), and adverse cardiometabolic risk was analyzed. RESULTS: Height, weight, and cardiometabolic risk measures were obtained for 22,352 children from 2014-18 in the primary cohort and 24,444 children in the replication cohort. Obesity (BMI >/= 95(th) percentile [BMI(pct95)]) was observed in 24.1% and severe obesity (BMI >/= 120% of BMI(pct95)) in 10.6%. Individuals with early onset obesity (age /= 0.854). CONCLUSIONS: The WMQ can be used for the Brazilian population, as it is reliable and has adequate internal structure, supporting its use in future research. FAU - Costa, Brigida Rodrigues da AU - Costa BRD AUID- ORCID: 0000-0001-8961-2166 AD - Programa de Pos-Graduacao em Meio Ambiente, Universidade Ceuma (Ceuma), Sao Luis (MA), Brazil. FAU - Dibai-Filho, Almir Vieira AU - Dibai-Filho AV AUID- ORCID: 0000-0001-5403-8248 AD - Programa de Pos-Graduacao em Educacao Fisica, Universidade Federal do Maranhao (UFMA), Sao Luis (MA), Brazil. FAU - Santos-de-Araujo, Aldair Darlan AU - Santos-de-Araujo AD AUID- ORCID: 0000-0001-6436-9059 AD - Programa de Pos-Graduacao em Fisioterapia, Universidade Federal de Sao Carlos (UFSCar), Sao Carlos (SP), Brazil. FAU - Pereira, Fabio Henrique Ferreira AU - Pereira FHF AUID- ORCID: 0000-0003-4734-003X AD - Programa de Pos-Graduacao em Meio Ambiente, Universidade Ceuma (Ceuma), Sao Luis (MA), Brazil. FAU - Bassi-Dibai, Daniela AU - Bassi-Dibai D AUID- ORCID: 0000-0002-6140-0177 AD - Programa de Pos-Graduacao em Meio Ambiente, Universidade Ceuma (Ceuma), Sao Luis (MA), Brazil. FAU - Rego, Adriana Sousa AU - Rego AS AUID- ORCID: 0000-0002-2494-030X AD - Programa de Pos-Graduacao em Meio Ambiente, Universidade Ceuma (Ceuma), Sao Luis (MA), Brazil. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250714 PL - Brazil TA - Sao Paulo Med J JT - Sao Paulo medical journal = Revista paulista de medicina JID - 100897261 SB - IM MH - Humans MH - Adult MH - Cross-Sectional Studies MH - Brazil MH - Male MH - Female MH - Middle Aged MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - Young Adult MH - Adolescent MH - *Translations MH - *Obesity/prevention & control MH - Cross-Cultural Comparison MH - Exercise PMC - PMC12263088 COIS- Conflicts of interest: :None EDAT- 2025/07/16 12:30 MHDA- 2025/07/16 12:31 PMCR- 2025/07/14 CRDT- 2025/07/16 08:53 PHST- 2024/06/21 00:00 [received] PHST- 2025/04/04 00:00 [accepted] PHST- 2025/07/16 12:31 [medline] PHST- 2025/07/16 12:30 [pubmed] PHST- 2025/07/16 08:53 [entrez] PHST- 2025/07/14 00:00 [pmc-release] AID - S1516-31802025000400206 [pii] AID - 10.1590/1516-3180.2024.0149.R2.10042025 [doi] PST - epublish SO - Sao Paulo Med J. 2025 Jul 14;143(4):e2024149. doi: 10.1590/1516-3180.2024.0149.R2.10042025. eCollection 2025. PMID- 40665434 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250719 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 13 IP - 1 DP - 2025 Jul 15 TI - Arabic translation and psychometric testing of the prenatal eating behaviors screening tool. PG - 138 LID - 10.1186/s40337-025-01264-4 [doi] LID - 138 AB - BACKGROUND: Early detection and treatment of eating behavioral problems among pregnant women are essential due to the associated adverse impact on pregnancy and the health of the offspring. Prenatal Eating Behaviors Screening (PEBS) tool, a 12-item self-administered questionnaire, can be used to screen for eating disorders (ED) during pregnancy. This study performed an Arabic translation of PEBS and a psychometric analysis to determine its validity and reliability. METHODS: The standard forward-backward translation method was used to generate PEBS-Arabic. The 12-item Likert scale questionnaire was completed by 116 antenatal women in the tertiary maternity care hospital in Qatar. Content validity was determined by the content validity index (CVI) using input from five experts. Reliability was assessed using Cronbach's alpha, and confirmatory and exploratory factor analysis (CFA & EFA) to test construct validity. The correlations between PEBS-Arabic scores and maternal characteristics were explored. RESULTS: The mean total PEBS score in the cohort was 16.3 (+/- 5.2), with nulliparity and higher educational level resulting in statistically significantly higher mean scores. The PEBS-Arabic had a very good item-CVI and scale-CVI of 1.00. The overall Cronbach's alpha was 0.77, which demonstrated good and acceptable reliability. The CFA using a single-factor solution showed an acceptable correlation for most items. In the EFA, a two-factor solution resulted in most items loading accurately into the pre-determined factors (bulimia and anorexia) with acceptable correlations. CONCLUSION: The PEBS-Arabic is the first translated version of this pregnancy-specific screening tool for ED. This tool demonstrates good reliability, content and construct validity. This study is a valuable step towards understanding and detecting the prevalence and determinants of ED in pregnancy, with the aim of improving maternal, fetal and child health. CI - (c) 2025. The Author(s). FAU - Silang, John Paul Ben AU - Silang JPB AD - Department of Research, Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar. jsilang@hamad.qa. AD - Nursing Department, Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar. jsilang@hamad.qa. FAU - Minisha, Fathima AU - Minisha F AD - Department of Research, Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar. AD - Obstetrics and Gynecology Department, Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar. FAU - A-Hajjaji, Hayat Qassim AU - A-Hajjaji HQ AD - Nursing Department, Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar. FAU - Lim, Catherine Medina AU - Lim CM AD - Nursing Department, Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar. FAU - Thankappan, Jishamol AU - Thankappan J AD - Nursing Department, Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar. FAU - Ali, B'Chira Bent Ismail Ben AU - Ali BBIB AD - Nursing Department, Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar. FAU - Prakash, Mani Megalai AU - Prakash MM AD - Nursing Department, Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar. FAU - Mohamed, Zeinab Abdillahi AU - Mohamed ZA AD - Nursing Department, Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar. FAU - Mathew, Remya AU - Mathew R AD - Nursing Department, Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar. FAU - De Jesus, David Hali AU - De Jesus DH AD - Nursing Department, Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar. FAU - Yaqoub, Salwa Mohammad Abu AU - Yaqoub SMA AD - Obstetrics and Gynecology Department, Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar. FAU - Farrell, Thomas AU - Farrell T AD - Department of Research, Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar. AD - Obstetrics and Gynecology Department, Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar. AD - College of Medicine, Qatar University, Doha, Qatar. LA - eng PT - Journal Article DEP - 20250715 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC12261738 OAB - The study aimed to determine the validity and reliability of the Prenatal Eating Behaviors Screening (PEBS) tool, a 12-item self-administered questionnaire, for early detection and treatment of eating disorders during pregnancy. The Arabic translation of PEBS and psychometric evaluation was performed. Moreover, a survey was conducted using PEBS which followed a six-point Likert scale which were completed by 116 antenatal women in Qatar. The results showed good reliability, and content and construct validity. The PEBS-Arabic is the first translated version from original English. This study is crucial for understanding and detecting the prevalence and determinants of eating disorders in pregnancy, ultimately improving maternal, fetal, and child health. OABL- eng OTO - NOTNLM OT - Eating behaviors OT - Eating disorders OT - PEBS OT - Prenatal eating disorders screening OT - Psychometric analysis COIS- Declarations. Ethics approval: The Institutional Review Board of the Medical Research Center, Hamad Medical Corporation, approved the conduct of the study (MRC 01-23-453). Permissions were sought from the authors of the original PEBS tool for adaptation, translation and psychometric testing. Detailed information about the study was provided to participants using research information sheets in order to obtain voluntary participation, prior to data collection. Competing interests: The authors have no conflicts of interest to declare. EDAT- 2025/07/16 00:26 MHDA- 2025/07/16 00:27 PMCR- 2025/07/15 CRDT- 2025/07/15 23:57 PHST- 2025/01/22 00:00 [received] PHST- 2025/04/09 00:00 [accepted] PHST- 2025/07/16 00:27 [medline] PHST- 2025/07/16 00:26 [pubmed] PHST- 2025/07/15 23:57 [entrez] PHST- 2025/07/15 00:00 [pmc-release] AID - 10.1186/s40337-025-01264-4 [pii] AID - 1264 [pii] AID - 10.1186/s40337-025-01264-4 [doi] PST - epublish SO - J Eat Disord. 2025 Jul 15;13(1):138. doi: 10.1186/s40337-025-01264-4. PMID- 40665062 OWN - NLM STAT- MEDLINE DCOM- 20250716 LR - 20250807 IS - 1436-6215 (Electronic) IS - 1436-6207 (Print) IS - 1436-6207 (Linking) VI - 64 IP - 5 DP - 2025 Jul 15 TI - Maternal adherence to the EAT-Lancet diet recommendations among pregnant women in Ireland and associations with offspring birth outcomes and childhood adiposity. PG - 238 LID - 10.1007/s00394-025-03756-0 [doi] LID - 238 AB - BACKGROUND AND AIMS: Pregnancy is a critical period during which maternal diet may impact offspring growth and future health. The EAT-Lancet commission promotes a plant-based diet pattern for meeting environmental and health challenges. EAT-Lancet diet scores have been developed however, thus far they have not been examined in the context of maternal-child health. We investigated adherence to EAT-Lancet diet recommendations during pregnancy and associations with offspring birth outcomes and childhood adiposity. The hypothesis tested was that greater adherence is not related to adverse outcomes. METHODS: This study included mother-child pairs (n = 1,052) from the Lifeways Cross-generational cohort, in Ireland. Maternal EAT-Lancet diet score was derived from an early pregnancy validated food frequency questionnaire. Correlation analysis examined relationships with other diet scores (Healthy Eating Index (HEI-2015), Dietary Approach to Stop Hypertension (DASH) score, and energy adjusted-Dietary Inflammatory Index (E-DII). Logistic and linear regression analyses examined associations with offspring birth outcomes and childhood adiposity and weight status at age 5 and 9 years, with adjustment for energy intake and potential confounders. RESULTS: The EAT-Lancet diet score (mean +/- SD 21.0 +/- 4.1) was moderately positively correlated with HEI-2015 and DASH scores (rho > 0.5) and negatively correlated with dietary inflammation (E-DII (rho < - 0.5, all p-value < 0.001)). Greater adherence to the EAT-Lancet diet recommendations was associated with higher intake of most micronutrients (except for retinol, riboflavin, vitamin B12 and calcium which were significantly lower). In energy-adjusted models, maternal EAT-Lancet diet score was positively associated with offspring birth weight (beta 8.77, 95% CI 0.35-17.19, p = 0.04), length (beta 0.06, 95% CI 0.01-0.1, p = 0.01), head circumference (beta 0.04, 95% CI 0.01-0.07, p = 0.01) and lower likelihood of having a low birth weight (Odds ratio 0.91, 95% CI 0.85-0.99, p = 0.01). These associations did not withstand adjustment for additional confounders. CONCLUSIONS: Adherence to EAT-Lancet diet recommendations during pregnancy was not associated with adverse short or long-term offspring outcomes. Further examination in other cohorts with more diverse diets, and with additional health outcomes, is warranted. CI - (c) 2025. The Author(s). FAU - Pen, Gregory AU - Pen G AD - School of Public Health, Physiotherapy, and Sports Science, University College Dublin, Room F13, Woodview House, Belfield, Dublin 4, Ireland. FAU - Douglass, Alexander AU - Douglass A AD - School of Public Health, Physiotherapy, and Sports Science, University College Dublin, Room F13, Woodview House, Belfield, Dublin 4, Ireland. FAU - Murrin, Celine M AU - Murrin CM AD - School of Public Health, Physiotherapy, and Sports Science, University College Dublin, Room F13, Woodview House, Belfield, Dublin 4, Ireland. FAU - Kelleher, Cecily C AU - Kelleher CC AD - School of Public Health, Physiotherapy, and Sports Science, University College Dublin, Room F13, Woodview House, Belfield, Dublin 4, Ireland. FAU - Aubert, Adrien M AU - Aubert AM AD - School of Public Health, Physiotherapy, and Sports Science, University College Dublin, Room F13, Woodview House, Belfield, Dublin 4, Ireland. FAU - Phillips, Catherine M AU - Phillips CM AUID- ORCID: 0000-0003-4916-4463 AD - School of Public Health, Physiotherapy, and Sports Science, University College Dublin, Room F13, Woodview House, Belfield, Dublin 4, Ireland. catherine.phillips@ucd.ie. LA - eng PT - Journal Article DEP - 20250715 PL - Germany TA - Eur J Nutr JT - European journal of nutrition JID - 100888704 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Ireland/epidemiology MH - Adult MH - Child MH - *Adiposity MH - Child, Preschool MH - *Maternal Nutritional Physiological Phenomena MH - Male MH - Cohort Studies MH - *Pediatric Obesity/epidemiology MH - *Diet, Healthy/statistics & numerical data MH - *Pregnancy Outcome/epidemiology MH - *Diet MH - *Patient Compliance/statistics & numerical data MH - Infant, Newborn MH - *Diet, Vegetarian PMC - PMC12263777 OTO - NOTNLM OT - Birth outcomes OT - Childhood obesity OT - Dietary intake OT - EAT-Lancet commission OT - Lifeways OT - Pregnancy diet COIS- Declarations. Conflict of interest: We do not have any conflicts of interest to disclose. EDAT- 2025/07/16 00:26 MHDA- 2025/07/16 06:25 PMCR- 2025/07/15 CRDT- 2025/07/15 23:38 PHST- 2025/03/18 00:00 [received] PHST- 2025/06/23 00:00 [accepted] PHST- 2025/07/16 06:25 [medline] PHST- 2025/07/16 00:26 [pubmed] PHST- 2025/07/15 23:38 [entrez] PHST- 2025/07/15 00:00 [pmc-release] AID - 10.1007/s00394-025-03756-0 [pii] AID - 3756 [pii] AID - 10.1007/s00394-025-03756-0 [doi] PST - epublish SO - Eur J Nutr. 2025 Jul 15;64(5):238. doi: 10.1007/s00394-025-03756-0. PMID- 40664716 OWN - NLM STAT- MEDLINE DCOM- 20250715 LR - 20250718 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Jul 15 TI - Conducting the National Health and Morbidity Survey 2023 in Malaysia with focus on methodology and main findings on non-communicable diseases. PG - 25531 LID - 10.1038/s41598-025-08311-9 [doi] LID - 25531 AB - The National Health and Morbidity Survey (NHMS), which focuses on non-communicable diseases (NCDs), their risk factors and healthcare demand, is a cross-sectional, nationwide, population-based survey conducted every four-year cycle since 2011. NHMS 2023 was the 7th cycle of NCDs, their risk factors and healthcare demand, which aimed to monitor trends in diseases and healthcare utilisation. This article outlines the methodology, sociodemographic characteristics, and overall findings from the population surveyed in 2023 regarding NCDs, their risk factors, and various health-related topics. This survey utilised a two-stage stratified random sampling design and encompassed fifteen main scopes, with sample sizes calculated to meet the specific requirements of each scope. Conducted from July to September 2023, it involved the random selection of 499 enumeration blocks(EBs) by the Department of Statistics Malaysia (DOSM) across all states and federal territories in Malaysia. The step resulted in the selection of 5,988 living quarters (LQs). Data collection methods included validated questionnaires administered through face-to-face interviews and self-administered questionnaires, alongside clinical assessments and blood investigations using calibrated devices. To ensure the high quality of the collected data, we implemented stringent quality control measures. Furthermore, we applied complex sampling analyses to ensure that the findings accurately represented the population in Malaysia. The survey received responses from 13,616 individuals out of the 5,006 LQs that were successfully visited, resulting in an overall response rate of the survey of 83.2%, which includes individuals aged 5 years and above. A substantial segment of the population lived in urban regions, comprising 77.6% of the total. About half of the population consisted of males (51.9%), Malay (54.6%), and individuals who had attained secondary education (54.2%). Additionally, 20.0% of the population were within the age range of 30 to 39 years. The weighted prevalence of diabetes was 15.6%, hypertension 29.2%, hypercholesterolaemia 33.3%, overweight and obesity 54.4%. Depression among adults was 4.6%, while mental health problems among children were reported at 16.5%. The current tobacco smokers prevalence was 19.0%, and 29.9% of adults in Malaysia were physically inactive. The known asthma prevalence among adults was 6.2%, while the current asthma among children was 3.4%. Additionally, 37.7% of adults experienced sleep insufficiency. The results indicate that the higher proportion of diabetes, hypertension, and hypercholesterolaemia, particularly among the young age group, and the high prevalence of overweight and obesity, as well as mental health problems, are making the healthcare system deal with more non-communicable diseases, complications, and problems. The methodology of this survey is robust for a population-based study. We took comprehensive steps to ensure the validity and reliability of the findings. The findings indicate an urgent need for targeted public health interventions to address the escalating health issues. By focusing on prevention and early intervention strategies, we can mitigate the impact of NCDs on the healthcare system and improve overall population health. CI - (c) 2025. The Author(s). FAU - Mat Rifin, Halizah AU - Mat Rifin H AD - Institute for Public Health, National Institutes of Health, Ministry of Health, Blok B5 & B6,Kompleks NIH, No. 1, Jalan Setia Murni U13/52, Seksyen U13 Setia Alam, Shah Alam, 40170, Selangor, Malaysia. halizah.matrifin@moh.gov.my. FAU - Mohd Yusoff, Muhammad Fadhli AU - Mohd Yusoff MF AD - Institute for Public Health, National Institutes of Health, Ministry of Health, Blok B5 & B6,Kompleks NIH, No. 1, Jalan Setia Murni U13/52, Seksyen U13 Setia Alam, Shah Alam, 40170, Selangor, Malaysia. FAU - Abd Hamid, Hamizatul Akmal AU - Abd Hamid HA AD - Institute for Public Health, National Institutes of Health, Ministry of Health, Blok B5 & B6,Kompleks NIH, No. 1, Jalan Setia Murni U13/52, Seksyen U13 Setia Alam, Shah Alam, 40170, Selangor, Malaysia. LA - eng GR - NMRR-22-00545-XAC/Kementerian Kesihatan Malaysia/ GR - NMRR-22-00545-XAC/Kementerian Kesihatan Malaysia/ GR - NMRR-22-00545-XAC/Kementerian Kesihatan Malaysia/ PT - Journal Article DEP - 20250715 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Noncommunicable Diseases/epidemiology MH - Malaysia/epidemiology MH - Male MH - Female MH - Middle Aged MH - Adult MH - *Health Surveys/methods MH - Aged MH - Adolescent MH - Cross-Sectional Studies MH - Young Adult MH - Risk Factors MH - Child MH - Child, Preschool MH - Morbidity MH - Surveys and Questionnaires PMC - PMC12264187 OTO - NOTNLM OT - Malaysia; National Health and Morbidity Survey (NHMS) 2023 OT - Methodology OT - Non-communicable diseases COIS- Declarations. Ethics approval and consent to participate: All respondents provided written informed consent prior to interviews. The survey protocol was approved by the Medical Research and Ethics Committee (MREC), Ministry of Health Malaysia (22-00545-XAC (2)). All methods adhered to the principles of the Declaration of Helsinki and the Malaysian Good Clinical Practice Guidelines. Competing interests: The authors declare no competing interests. EDAT- 2025/07/16 00:26 MHDA- 2025/07/16 00:27 PMCR- 2025/07/15 CRDT- 2025/07/15 23:18 PHST- 2025/03/10 00:00 [received] PHST- 2025/06/20 00:00 [accepted] PHST- 2025/07/16 00:27 [medline] PHST- 2025/07/16 00:26 [pubmed] PHST- 2025/07/15 23:18 [entrez] PHST- 2025/07/15 00:00 [pmc-release] AID - 10.1038/s41598-025-08311-9 [pii] AID - 8311 [pii] AID - 10.1038/s41598-025-08311-9 [doi] PST - epublish SO - Sci Rep. 2025 Jul 15;15(1):25531. doi: 10.1038/s41598-025-08311-9. PMID- 40664057 OWN - NLM STAT- MEDLINE DCOM- 20251126 LR - 20260529 IS - 1873-6947 (Electronic) IS - 1744-3881 (Linking) VI - 61 DP - 2025 Nov TI - Is meeting 24-h movement guidelines lowering the odds of depressive symptoms? Results of a large-scale survey based on U.S. adolescents. PG - 102005 LID - S1744-3881(25)00070-2 [pii] LID - 10.1016/j.ctcp.2025.102005 [doi] AB - BACKGROUND: Adolescents who experience mental health issues are at a high rate of health risk, this underscores the significance of researching potential risks and protective factors of mental health problemes. 24-hour movement behaviors, encompassing physical activity, sedentary behavior and sleep, constitute a group of alterable way of life factors that have shown to be associated with depressive symptoms. Therefore, the main aim of this study was to investigate the association between compliance with 24-h movement guidelines and the presence of depressive symptoms in adolescents. METHODS: The sampling process comprised three stages involving students between the age of 14 and 18 years old, enrolled in grades 9-12. A total of 92,467 participants (aged: 14-17 years, body mass index: 23.44 +/- 5.19) were included for the analysis, with 47.6 % being boys. Validated self-reported questionnaires were utilized to measure physical activity (PA), screen time (ST), sleep duration, and depressive symptoms. Binary logistic regression analyses were performed to explore the associations between the complicance with the 24-h movement guidelines and presence of depressive symptoms. For statistical significance, a p-value less than 0.05 was used. RESULTS: Participants not meeting any guidelines exhibited significantly higher odds of experiencing emotions of sorrow or despair, with an odds ratio (OR) of 4.28 (95 % CI: 3.56-5.14) compared to those who fulfilled all three guidelines. Similarly, participants meeting only one of the guidelines displayed significantly higher odds of experiencing emotions of sorrow or despair, with an OR of 2.79 (95 % CI: 2.43-3.21) compared to those adhering to all three guidelines. Those meeting two of the guidelines also demonstrated significantly higher odds of experiencing emotions of sorrow or despair, with an OR of 1.63 (95 % CI: 1.46-1.83) compared to those adhering to all three guidelines. CONCLUSION: The findings of this study offer preliminary evidence supporting an inverse association between compliance with 24-h movement guidelines and reduced depressive symptoms among adolescents. However, longitudinal study is imperative to more comprehensively ascertain these associations before considering the recommendation of compliance with 24-h movement guidelines as an intervention for adolescent depression. CI - Copyright (c) 2025. Published by Elsevier Ltd. FAU - Lv, Yuanyang AU - Lv Y AD - College of Physical Education, Southwest University, Chongqing, China. FAU - Lu, Yingna AU - Lu Y AD - School of Elite Sport, Shanghai University of Sport, Shanghai, China. Electronic address: yingnalu@outlook.com. LA - eng PT - Journal Article DEP - 20250619 PL - England TA - Complement Ther Clin Pract JT - Complementary therapies in clinical practice JID - 101225531 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - *Depression/epidemiology/prevention & control MH - *Exercise/physiology/psychology MH - Sedentary Behavior MH - Sleep/physiology MH - Surveys and Questionnaires MH - United States MH - Screen Time MH - Guidelines as Topic COIS- Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/07/16 00:26 MHDA- 2025/11/27 00:27 CRDT- 2025/07/15 18:07 PHST- 2024/07/16 00:00 [received] PHST- 2025/06/01 00:00 [revised] PHST- 2025/06/19 00:00 [accepted] PHST- 2025/11/27 00:27 [medline] PHST- 2025/07/16 00:26 [pubmed] PHST- 2025/07/15 18:07 [entrez] AID - S1744-3881(25)00070-2 [pii] AID - 10.1016/j.ctcp.2025.102005 [doi] PST - ppublish SO - Complement Ther Clin Pract. 2025 Nov;61:102005. doi: 10.1016/j.ctcp.2025.102005. Epub 2025 Jun 19. PMID- 40663105 OWN - NLM STAT- MEDLINE DCOM- 20250924 LR - 20251126 IS - 1827-1928 (Electronic) IS - 0022-4707 (Linking) VI - 65 IP - 9 DP - 2025 Sep TI - Accuracy and cross-validity of the Xiaomi Mi Band 2, 3, 4, and 5 wristbands in evaluating physical activity in adolescents according to WHO 2020 guidelines: School-Fit study. PG - 1210-1220 LID - 10.23736/S0022-4707.25.15590-4 [doi] AB - BACKGROUND: The aims of the present study were to examine the accuracy and cross-validity of Xiaomi Mi Band (XMB) 2, 3, 4 and 5 activity wristband-measured daily physical activity thresholds related to achieving at least the recommended 60 minutes per day of moderate-to-vigorous intensity physical activity in adolescents. METHODS: Following a cross-sectional design, 70 adolescents (final sample=62; 54.84% females), aged 11-17 years old, from a public high school wore the activity wristbands XMB 2, 3, 4 and 5 (non-dominant wrist; index tests=steps, slow- and/or brisk-pace walking, total physical activity and moderate-to-vigorous physical activity) and ActiGraph wGT3X-BT accelerometers (right hip; reference standard=moderate-to-vigorous intensity physical activity) for a day. 29.03% of the adolescents achieved the moderate-to-vigorous intensity physical activity recommendation. RESULTS: The results of the Receiver Operating Characteristic curve analyses showed that the accuracy of the activity wristband-measured daily steps thresholds was excellent (e.g., Sensitivity=1.00, Specificity=0.91, k=0.85), being higher than those with intensity-related physical activity outputs. The cross-validity results showed that thresholds from 8,521 to 9,070 steps/day had excellent values (e.g., Sensitivity/Specificity >/=0.90, k>/=0.75). CONCLUSIONS: Activity wristband-measured daily steps thresholds are more accurate than those with intensity-related physical activity outputs for evaluating the recommended 60 minutes per day of moderate-to-vigorous intensity physical activity. A 9000-step-per-day recommendation is a simple and accurate activity wristband-based recommendation for adolescents. FAU - Mayorga-Vega, Daniel AU - Mayorga-Vega D AD - Departamento de Didactica de las Lenguas, las Artes y el Deporte, Facultad de Ciencias de la Educacion, Universidad de Malaga, Malaga, Spain. FAU - Guijarro-Romero, Santiago AU - Guijarro-Romero S AD - Department of Physical Education, Sport and Human Movement, Autonomous University of Madrid, Madrid, Spain - santiago.guijarro@uam.es. FAU - Casado-Robles, Carolina AU - Casado-Robles C AD - Department of Physical Education and Sport, University of Granada, Granada, Spain. FAU - Viciana, Jesus AU - Viciana J AD - Department of Physical Education and Sport, University of Granada, Granada, Spain. LA - eng PT - Journal Article PT - Validation Study DEP - 20250715 PL - Italy TA - J Sports Med Phys Fitness JT - The Journal of sports medicine and physical fitness JID - 0376337 SB - IM EIN - J Sports Med Phys Fitness. 2025 Dec;65(12):1682. doi: 10.23736/S0022-4707.25.17752-9. PMID: 41292363 MH - Humans MH - Adolescent MH - Female MH - Male MH - Cross-Sectional Studies MH - Child MH - *Exercise/physiology MH - Reproducibility of Results MH - *Fitness Trackers/standards MH - World Health Organization MH - Wrist MH - *Accelerometry/instrumentation EDAT- 2025/07/15 12:29 MHDA- 2025/09/24 13:01 CRDT- 2025/07/15 11:05 PHST- 2025/09/24 13:01 [medline] PHST- 2025/07/15 12:29 [pubmed] PHST- 2025/07/15 11:05 [entrez] AID - S0022-4707.25.15590-4 [pii] AID - 10.23736/S0022-4707.25.15590-4 [doi] PST - ppublish SO - J Sports Med Phys Fitness. 2025 Sep;65(9):1210-1220. doi: 10.23736/S0022-4707.25.15590-4. Epub 2025 Jul 15. PMID- 40662908 OWN - NLM STAT- MEDLINE DCOM- 20260218 LR - 20260813 IS - 1502-7724 (Electronic) IS - 0281-3432 (Print) IS - 0281-3432 (Linking) VI - 44 IP - 1 DP - 2026 Dec TI - Not for children's ears? Parents' insights into early childhood overweight and obesity treatment. PG - 1-12 LID - 10.1080/02813432.2025.2531958 [doi] AB - This study offers novel insights into parents' experiences of healthcare interactions during weight-related visits. Data were collected through the More and Less Europe study, a randomized controlled trial evaluating a parent support program for children (aged 2-6 years) with overweight or obesity in Sweden, Romania, and Spain to capture parents' experiences of healthcare interactions. Semi-structured interviews were conducted with 45 Swedish parents (71% mothers, 60% with university degree, 51% of migrant background) of 45 children (mean age 7.1 years, SD 1.3, 76% girls) who received standard treatment for overweight or obesity. The interviews were analyzed thematically, identifying two themes: (1) Support or blame, with subthemes Validating family-centeredness, Overly generic advice, and Stigma and the sense of failing; (2) The place and role of the child, with subthemes Neutral, honest, and direct communication, Not for children's ears, and Framing the message with care. While some parents described supportive interactions, others expressed disappointment with generic advice and inadequate support. Some recalled stigmatization, sometimes in the child's presence, raising concerns about the child's well-being. Approaches to preparing children for visits ranged from neutral to direct explanations. Parents expressed contrasting views on children's presence during weight-related discussions: while some felt such discussions would harm their child, others supported children's presence in open and age-appropriate discussion. This study fills a critical gap in obesity management communication by highlighting parental concerns about children's exposure to weight-related discussions. Addressing these concerns is essential to reducing weight stigma in healthcare and protecting children from harmful experiences. FAU - Sjunnestrand, My AU - Sjunnestrand M AD - Department of Food Studies, Nutrition and Dietetics, Uppsala University, Uppsala, Sweden. FAU - Neuman, Nicklas AU - Neuman N AUID- ORCID: 0000-0001-7970-4753 AD - Department of Food Studies, Nutrition and Dietetics, Uppsala University, Uppsala, Sweden. FAU - Ek, Anna AU - Ek A AD - Department of Clinical Science, Intervention and Technology (CLINTEC), Stockholm, Sweden. FAU - Nordin, Karin AU - Nordin K AD - Department of Clinical Science, Intervention and Technology (CLINTEC), Stockholm, Sweden. FAU - Ramos Salas, Ximena AU - Ramos Salas X AD - Replica Communications, Kristianstad, Sweden and Bias 180, Dundas, Canada. FAU - Jarvholm, Kajsa AU - Jarvholm K AD - Department of Psychology, Lund University, Lund, Sweden. FAU - Eli, Karin AU - Eli K AD - Warwick Medical School, University of Warwick, Coventry, UK. FAU - Nowicka, Paulina AU - Nowicka P AD - Department of Food Studies, Nutrition and Dietetics, Uppsala University, Uppsala, Sweden. AD - Department of Clinical Science, Intervention and Technology (CLINTEC), Stockholm, Sweden. LA - eng PT - Journal Article DEP - 20250715 PL - United States TA - Scand J Prim Health Care JT - Scandinavian journal of primary health care JID - 8510679 SB - IM MH - Humans MH - Female MH - Male MH - Child MH - *Parents/psychology MH - *Pediatric Obesity/therapy/psychology MH - Child, Preschool MH - Social Stigma MH - Adult MH - Qualitative Research MH - Sweden MH - *Overweight/therapy MH - Romania MH - Spain MH - Interviews as Topic MH - Communication MH - Social Support PMC - PMC12918314 OAB - Offers novel insights into parents' experiences with HCP in weight discussionsReveals how parents approach involving children in weight-related conversationsShows that parents' experiences of HCPs range from supportive to stigmatizingUncovers conflicting parental views on including children in weight discussionsStresses the need for HCPs to adopt a sensitive and non-judgmental approach. OABL- eng OTO - NOTNLM OT - Childhood obesity OT - childhood obesity treatment OT - healthcare OT - healthcare interactions OT - stigma OT - weight-related communication COIS- The authors declare no conflicts of interest (COI) related to this work. KJ reports COI unrelated to this work: lecturing for companies, with reimbursement made to her clinical institution. XRS reports COI unrelated to this work: consulting fees from international non-profit organizations and speaker honoraria from NN. As an independent researcher, XRS owns a research consulting company in Sweden (K&X Ramos AB), is a partner in a private communications company (Replica Communications), and serves as chair of Bias 180, a global non-profit organization focused on reducing chronic disease-related stigma. EDAT- 2025/07/15 12:29 MHDA- 2026/02/18 14:56 PMCR- 2025/07/15 CRDT- 2025/07/15 09:34 PHST- 2026/02/18 14:56 [medline] PHST- 2025/07/15 12:29 [pubmed] PHST- 2025/07/15 09:34 [entrez] PHST- 2025/07/15 00:00 [pmc-release] AID - 2531958 [pii] AID - 10.1080/02813432.2025.2531958 [doi] PST - ppublish SO - Scand J Prim Health Care. 2026 Dec;44(1):1-12. doi: 10.1080/02813432.2025.2531958. Epub 2025 Jul 15. PMID- 40662887 OWN - NLM STAT- MEDLINE DCOM- 20250812 LR - 20250828 IS - 1552-8456 (Electronic) IS - 0193-9459 (Linking) VI - 47 IP - 9 DP - 2025 Sep TI - Validity and Reliability of the Korean Version of the Self-Efficacy Scale for Healthy Eating and Physical Activity Among Pregnant Women. PG - 887-896 LID - 10.1177/01939459251351464 [doi] AB - OBJECTIVE: Excessive gestational weight gain, driven by the global raise in obesity, poses significant health risks for both mothers and infants. This study aimed to validate and assess the reliability of the Korean version of the self-efficacy scale for healthy eating and physical activity to support pregnancy-related weight management research in Korea. METHODS: This study is a secondary data analysis using previously collected data from an online survey of pregnant women in South Korea. The self-efficacy scale underwent linguistic validation, including translation, back-translation, and expert review. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were conducted to assess content and construct validity, along with internal consistency reliability testing. RESULTS: A total of 369 pregnant women participated, primarily in their 30s (85.1%) and college-educated (79.1%). Content validity was high, with a scale-level content validity index of 0.99. Construct validity was confirmed through EFA and CFA, with the final model achieving satisfactory fit indices (chi(2)/df = 2.19, CFI = 0.90, TLI = 0.89, SRMR = 0.07, RMSEA = 0.06). The scale demonstrated high reliability, with Cronbach's alpha values of 0.93 for both subscales. CONCLUSION: The validated Korean self-efficacy scale is a reliable tool for assessing pregnancy-related weight management behaviors. This culturally adapted instrument can support research and interventions promoting healthy eating and physical activity among Korean pregnant women. FAU - Kim, Sehee AU - Kim S AUID- ORCID: 0009-0002-9608-4431 AD - Department of Nursing, Daejeon Institute of Science and Technology, Daejeon, Republic of Korea. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250715 PL - United States TA - West J Nurs Res JT - Western journal of nursing research JID - 7905435 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Self Efficacy MH - Republic of Korea MH - *Exercise/psychology MH - Adult MH - Reproducibility of Results MH - *Psychometrics/instrumentation/standards/methods MH - Surveys and Questionnaires MH - *Pregnant People/psychology MH - *Diet, Healthy/psychology/standards MH - Factor Analysis, Statistical MH - Translations OTO - NOTNLM OT - gestational weight gain OT - healthy eating OT - physical activity OT - pregnancy OT - self-efficacy COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/07/15 12:29 MHDA- 2025/08/12 12:29 CRDT- 2025/07/15 09:33 PHST- 2025/08/12 12:29 [medline] PHST- 2025/07/15 12:29 [pubmed] PHST- 2025/07/15 09:33 [entrez] AID - 10.1177/01939459251351464 [doi] PST - ppublish SO - West J Nurs Res. 2025 Sep;47(9):887-896. doi: 10.1177/01939459251351464. Epub 2025 Jul 15. PMID- 40661684 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250717 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - The association between the albumin to globulin ratio and thoracic spine bone mineral density in adolescents: NHANES 2011-2016. PG - 1560013 LID - 10.3389/fnut.2025.1560013 [doi] LID - 1560013 AB - BACKGROUND: Numerous studies have demonstrated a strong correlation between osteoporosis and nutritional status and inflammation, while albumin and globulin are important references for nutritional status and inflammation, respectively. The albumin to globulin ratio (AGR), which combines the levels of albumin (ALB) and globulin (GLB), is a new comprehensive index that offers a more precise reflection of the inflammatory state of the body and its nutritional status. However, the connection between AGR and thoracic spine bone mineral density (BMD) remains poorly understood. The purpose of this research was to examine the link between the AGR and thoracic spine BMD in adolescents. METHODS: This study used the most recent data from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2016, and used weighted multivariate linear regression modeling to examine the correlation between AGR and thoracic spine BMD in adolescents. Threshold effects and non-linear relationships were assessed using a smoothed curve-fitting algorithm alongside threshold effects analysis. Furthermore, subgroup analyses and interaction tests were performed. RESULTS: The study comprised a total of 3,000 participants who were all aged 20 years or younger. Based on weighted multivariate linear regression analysis, in the fully adjusted model, a significantly higher thoracic spine BMD was found in the highest AGR quartile compared to the lowest AGR quartile (p < 0.05). After adjusting for variables, subgroup analyses showed no significant interaction effects. The study of threshold effects and the fitting of smooth curves identified a specific threshold effect for AGR and thoracic BMD with an inflection point of 1.237, after which AGR was significantly positively correlated with thoracic spine BMD. CONCLUSION: The study identified a notable positive correlation between AGR and adolescent thoracic spine BMD. This finding indicates a potential correlation between higher AGR and higher thoracic spine BMD, which may be indicative of a reduced risk of developing Osteoporosis (OP). This emphasizes the importance of considering nutritional and inflammatory status in the prevention of OP, thereby validating the utilization of AGR as a pivotal marker for the development of early intervention methodologies. CI - Copyright (c) 2025 Yan, Yang, Dai, Li, Zhang and Li. FAU - Yan, Haoyu AU - Yan H AD - Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, China. FAU - Yang, Jie AU - Yang J AD - Department of Family Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, China. FAU - Dai, Yancheng AU - Dai Y AD - Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, China. FAU - Li, Yan AU - Li Y AD - Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, China. FAU - Zhang, Peng AU - Zhang P AD - Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, China. FAU - Li, Liuyan AU - Li L AD - Guangfu People's Hospital, Suzhou, China. LA - eng PT - Journal Article DEP - 20250626 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12258045 OTO - NOTNLM OT - NHANES OT - adolescent OT - albumin to globulin ratio (AGR) OT - bone mineral density (BMD) OT - osteoporosis COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/07/15 06:27 MHDA- 2025/07/15 06:28 PMCR- 2025/06/26 CRDT- 2025/07/15 05:04 PHST- 2025/01/13 00:00 [received] PHST- 2025/05/20 00:00 [accepted] PHST- 2025/07/15 06:28 [medline] PHST- 2025/07/15 06:27 [pubmed] PHST- 2025/07/15 05:04 [entrez] PHST- 2025/06/26 00:00 [pmc-release] AID - 10.3389/fnut.2025.1560013 [doi] PST - epublish SO - Front Nutr. 2025 Jun 26;12:1560013. doi: 10.3389/fnut.2025.1560013. eCollection 2025. PMID- 40661126 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250717 IS - 2391-5463 (Print) IS - 2391-5463 (Electronic) VI - 20 IP - 1 DP - 2025 TI - Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study. PG - 20251177 LID - 10.1515/med-2025-1177 [doi] LID - 20251177 AB - BACKGROUND: Previous research has indicated a possible association between asthma and ankylosing spondylitis (AS). METHODS: We pinpointed single nucleotide polymorphisms linked to various forms of asthma and AS, employing them as instrumental variables for a bidirectional two-sample Mendelian randomization (TSMR) analysis. Our TSMR analysis focused on European populations to minimize racial confounding. Multivariate adjustments for body mass index (BMI), smoking, and alcohol use were performed to control for confounders. Colocalization analysis was used to validate MR findings and explore genetic links between asthma and AS. RESULTS: Individuals with asthma and eosinophilic asthma exhibited a relatively higher risk of AS (asthma: OR 1.31, 95% CI 1.07-1.62, P = 0.008; eosinophilic asthma: OR 1.24, 95% CI 1.005-1.544, P = 0.044). Allergic asthma, childhood-onset asthma, and obesity-related asthma showed no causal relationship with AS (allergic asthma: IVW P = 0.27; childhood-onset asthma: IVW P = 0.66; obesity-related asthma: IVW P = 0.53). After adjusting for cigarette smoking, alcohol consumption, and BMI, the results supported a direct causal effect of asthma on the increased risk of AS onset (IVW P = 0.001). CONCLUSION: This study revealed that a positive causal connection between asthma, specifically eosinophilic asthma, and AS. CI - (c) 2025 the author(s), published by De Gruyter. FAU - Yao, Yiming AU - Yao Y AD - Department of Respiratory and Critical Care Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 510000, China. FAU - Zhou, Shiqiang AU - Zhou S AD - Department of Respiratory and Critical Care Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 510000, China. FAU - Fang, Yumin AU - Fang Y AD - Department of Respiratory and Critical Care Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 510000, China. FAU - Zeng, Wenxing AU - Zeng W AD - Department of Traumatology, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 510000, China. FAU - Zhan, Shaofeng AU - Zhan S AD - Department of Respiratory and Critical Care Medicine, Guangzhou University of Chinese Medicine, 16 Jichang Road, Baiyun District, Guangzhou, Guangdong Province, 510000, China. LA - eng PT - Journal Article DEP - 20250708 PL - Poland TA - Open Med (Wars) JT - Open medicine (Warsaw, Poland) JID - 101672167 PMC - PMC12258423 OTO - NOTNLM OT - Mendelian randomization OT - ankylosing spondylitis OT - asthma OT - causal relationship OT - eosinophilic asthma COIS- Conflict of interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/07/15 06:27 MHDA- 2025/07/15 06:28 PMCR- 2025/07/08 CRDT- 2025/07/15 04:55 PHST- 2024/09/12 00:00 [received] PHST- 2025/02/08 00:00 [revised] PHST- 2025/03/12 00:00 [accepted] PHST- 2025/07/15 06:28 [medline] PHST- 2025/07/15 06:27 [pubmed] PHST- 2025/07/15 04:55 [entrez] PHST- 2025/07/08 00:00 [pmc-release] AID - med-2025-1177 [pii] AID - 10.1515/med-2025-1177 [doi] PST - epublish SO - Open Med (Wars). 2025 Jul 8;20(1):20251177. doi: 10.1515/med-2025-1177. eCollection 2025. PMID- 40660487 OWN - NLM STAT- MEDLINE DCOM- 20250715 LR - 20250715 IS - 1750-3841 (Electronic) IS - 0022-1147 (Linking) VI - 90 IP - 7 DP - 2025 Jul TI - Challenges to Insect-Based Food Acceptance: An Analysis of Neophobia Exploring Cognitive Aspects of the Mexican Consumers. PG - e70398 LID - 10.1111/1750-3841.70398 [doi] AB - The rising interest in alternative proteins has led to exploring insects as a sustainable option, but food neophobia hinders acceptance. This study analyzed insect-based food neophobia among 620 Mexican consumers via an online survey, considering emotions, memories, protein type, gender, and consumer context. A Google Forms questionnaire assessed neophobia based on cognitive dimensions, with high reliability (Cronbach's alpha = 0.93-0.94). ANOVA revealed that protein type and gender significantly influenced emotions, while protein type, gender, and consumer context affected memory recall. Men experienced more emotions and memories than women, and urban consumers recalled more memories than rural ones. Both genders associated insect-based food with negative memories. Cognitive mapping showed that insect-based food elicited negative emotions (disgust, aggression, worry, wildness, boredom) and memories (disease, poverty, pain, accidents, stench, hurt, conflict). These results highlight the need to address cognitive factors to improve consumer acceptance of insect-based food as a sustainable food source. Practical Application: This research helps food producers and marketers understand the psychological barriers to insect-based food acceptance among Mexican consumers. By identifying key emotions and memories linked to neophobia, companies can develop targeted strategies-such as educational campaigns or product reformulation-to improve consumer perception. These insights can support the sustainable food industry in making insect-based proteins more appealing and accessible. CI - (c) 2025 Institute of Food Technologists. FAU - Ramirez-Rivera, Emmanuel de Jesus AU - Ramirez-Rivera EJ AD - Tecnologico Nacional de Mexico, Instituto Tecnologico Superior de Zongolica, Zongolica, Veracruz, Mexico. FAU - Cabal-Prieto, Adan AU - Cabal-Prieto A AD - Tecnologico Nacional de Mexico, Campus Huatusco, Huatusco, Veracruz, Mexico. FAU - Gomez-Romero, Emmanuel AU - Gomez-Romero E AD - Tecnologico Nacional de Mexico, Instituto Tecnologico Superior de Zongolica, Zongolica, Veracruz, Mexico. FAU - Oney-Montalvo, Julio Enrique AU - Oney-Montalvo JE AD - Tecnologico Nacional de Mexico, Campus Calkini, Calkini, Campeche, Mexico. FAU - Can-Herrera, Luis Alfonso AU - Can-Herrera LA AD - Tecnologico Nacional de Mexico, Campus Calkini, Calkini, Campeche, Mexico. FAU - Hernandez-Salinas, Gregorio AU - Hernandez-Salinas G AD - Tecnologico Nacional de Mexico, Instituto Tecnologico Superior de Zongolica, Zongolica, Veracruz, Mexico. FAU - Sanchez-Orea, Jose Manuel AU - Sanchez-Orea JM AD - Tecnologico Nacional de Mexico, Instituto Tecnologico Superior de Zongolica, Zongolica, Veracruz, Mexico. FAU - Valdivia-Sanchez, Jasiel AU - Valdivia-Sanchez J AD - Tecnologico Nacional de Mexico, Instituto Tecnologico Superior de Zongolica, Zongolica, Veracruz, Mexico. FAU - Martinez, Ana Laura Pina AU - Martinez ALP AD - Tecnologico Nacional de Mexico, Campus Huatusco, Huatusco, Veracruz, Mexico. FAU - Resendiz, Jose de Jesus Gonzalez AU - Resendiz JJG AD - Tecnologico Nacional de Mexico, Campus Huatusco, Huatusco, Veracruz, Mexico. FAU - Rodriguez-Miranda, Jesus AU - Rodriguez-Miranda J AUID- ORCID: 0000-0002-1290-5670 AD - Tecnologico Nacional de Mexico, Campus Tuxtepec, Tuxtepec, Oaxaca, Mexico. FAU - da Cruz, Adriano Gomes AU - da Cruz AG AUID- ORCID: 0000-0002-9285-9669 AD - Department of Food, Instituto Federal de Educacao, Ciencia e Tecnologia do Rio de Janeiro (IFRJ), Rio de Janeiro, Brazil. FAU - Rosa, Mariana C AU - Rosa MC AD - Department of Food, Instituto Federal de Educacao, Ciencia e Tecnologia do Rio de Janeiro (IFRJ), Rio de Janeiro, Brazil. FAU - Juarez-Barrientos, Jose Manuel AU - Juarez-Barrientos JM AUID- ORCID: 0000-0003-4039-8028 AD - Universidad del Papaloapan Campus Loma Bonita, Loma Bonita, Oaxaca, Mexico. LA - eng PT - Journal Article PL - United States TA - J Food Sci JT - Journal of food science JID - 0014052 SB - IM MH - Humans MH - Male MH - Mexico MH - Female MH - Adult MH - *Consumer Behavior MH - Animals MH - Middle Aged MH - Surveys and Questionnaires MH - Young Adult MH - *Food Preferences/psychology MH - Emotions MH - *Cognition MH - Adolescent MH - *Edible Insects MH - Insecta MH - Memory OTO - NOTNLM OT - consumer acceptance OT - emotions and food OT - food neophobia OT - insect-based food OT - sensory and cognitive perception EDAT- 2025/07/15 06:27 MHDA- 2025/07/15 06:28 CRDT- 2025/07/15 00:33 PHST- 2025/06/11 00:00 [revised] PHST- 2025/03/04 00:00 [received] PHST- 2025/06/23 00:00 [accepted] PHST- 2025/07/15 06:28 [medline] PHST- 2025/07/15 06:27 [pubmed] PHST- 2025/07/15 00:33 [entrez] AID - 10.1111/1750-3841.70398 [doi] PST - ppublish SO - J Food Sci. 2025 Jul;90(7):e70398. doi: 10.1111/1750-3841.70398. PMID- 40659405 OWN - NLM STAT- MEDLINE DCOM- 20250714 LR - 20250717 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 7 DP - 2025 Jul 13 TI - Method for Observing SMOKing and vaping bEhaviours (MOSMOKE): development and validation of a systematic observation tool. PG - e105510 LID - 10.1136/bmjopen-2025-105510 [doi] LID - e105510 AB - OBJECTIVE: Policies and interventions increasingly aim to reduce smoking in outdoor public spaces, but evidence on factors influencing smoking in specific locations remains limited. Systematic observation can unobtrusively assess behaviours in environmental contexts, reducing biases from self-report. This study aims to develop and test the reliability and validity of MOSMOKE (Method for Observing SMOKing and vaping bEhaviours): a new tool for assessing the number of people holding or inhaling a cigarette or vape in public spaces. DESIGN: MOSMOKE was adapted from a previously validated observation tool for assessing physical activity and well-being behaviours. Following piloting and refinement, inter-rater reliability for assessing smoking, vaping and age group classification was analysed using intraclass correlation coefficients (ICCs). A main study assessed criterion-related validity through 32 hours of observations over 4 days. A 2x2 study design was used, with four sites selected that varied by two environmental characteristics: presence of a smoking bin and adjacency to an office block. SETTING: Four public spaces in Manchester, UK. RESULTS: Inter-rater reliability was 'good' (ICCs>0.75; n=4) or 'excellent' (ICCs>0.90; n=2) for smoking behaviours, and mostly 'good' (n=4) or 'excellent' (n=1) for vaping behaviours. Observed differences in smoking and vaping behaviours across sites aligned with prespecified hypotheses that smoking would be more prevalent near smoking bins (p=0.02) and office entrances (p=0.006), supporting criterion-related validity. CONCLUSIONS: This study provides preliminary evidence that MOSMOKE is a reliable and valid tool for unobtrusively assessing smoking and vaping in public spaces. It can be used to evaluate policies and interventions targeting smoking or vaping in specific environmental contexts. MOSMOKE is freely available, with a detailed manual to support its use. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY. Published by BMJ Group. FAU - Benton, Jack S AU - Benton JS AUID- ORCID: 0000-0002-7129-550X AD - Department of Geography, School of Environment, Education and Development, The University of Manchester, Manchester, UK jack.benton@manchester.ac.uk. FAU - Berg, Sofia AU - Berg S AD - Manchester Centre for Health Psychology, Division of Psychology & Mental Health, School of Health Sciences, The University of Manchester, Manchester, UK. FAU - Kapadi, Arbaz AU - Kapadi A AD - Manchester Centre for Health Psychology, Division of Psychology & Mental Health, School of Health Sciences, The University of Manchester, Manchester, UK. FAU - Bendel, Neil AU - Bendel N AD - Department of Public Health, Manchester City Council, Manchester, UK. FAU - Jerram, Julie AU - Jerram J AD - Department of Public Health, Manchester City Council, Manchester, UK. FAU - French, David P AU - French DP AUID- ORCID: 0000-0002-7663-7804 AD - Manchester Centre for Health Psychology, Division of Psychology & Mental Health, School of Health Sciences, The University of Manchester, Manchester, UK. LA - eng PT - Journal Article PT - Validation Study DEP - 20250713 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Vaping/epidemiology MH - Reproducibility of Results MH - *Smoking/epidemiology/psychology MH - Male MH - Female MH - Adult MH - Young Adult MH - Middle Aged MH - Adolescent MH - *Behavior Observation Techniques/methods MH - United Kingdom PMC - PMC12258348 OTO - NOTNLM OT - PUBLIC HEALTH OT - Psychometrics OT - Smoking Reduction COIS- Competing interests: None declared. EDAT- 2025/07/15 00:30 MHDA- 2025/07/15 00:31 PMCR- 2025/07/13 CRDT- 2025/07/14 20:53 PHST- 2025/07/15 00:31 [medline] PHST- 2025/07/15 00:30 [pubmed] PHST- 2025/07/14 20:53 [entrez] PHST- 2025/07/13 00:00 [pmc-release] AID - bmjopen-2025-105510 [pii] AID - 10.1136/bmjopen-2025-105510 [doi] PST - epublish SO - BMJ Open. 2025 Jul 13;15(7):e105510. doi: 10.1136/bmjopen-2025-105510. PMID- 40659218 OWN - NLM STAT- MEDLINE DCOM- 20250907 LR - 20260524 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 214 DP - 2025 Oct 1 TI - Tracking the shift from health to harm: Development and validation of a short screening tool for orthorexia nervosa (STONE). PG - 108227 LID - S0195-6663(25)00380-0 [pii] LID - 10.1016/j.appet.2025.108227 [doi] AB - Orthorexia Nervosa (ON), a problematic fixation on healthy eating, has captured researchers' attention for over a decade. We aimed to develop a brief screening tool for ON that captures physical appearance as a motivating factor, behavioural aspects (rigid control over food selection, consumption and preparation), and nutritional aspects (avoidance of foods considered "impure"). Using a sequential, iterative design, 687 participants completed a self-reported survey across four studies: item identification and selection through exploratory factor analysis (n = 248), testing factorial construct validity with confirmatory factor analysis (n = 127), discriminant validity via known group differences (n = 241), and test-retest reliability of two subsequent administrations of the selected items (n = 71). The final unidimensional version of the short Screening Tool for Orthorexia Nervosa (STONE) comprises eight items. It demonstrated excellent known-group validity and ability to differentiate ON from other types of strict dietary control (e.g., health-based or religious restrictions). Consistent with the view of ON as behaviours aimed at rigid dietary control, avoidance of "impure" foods, and motivation to enhance physical appearance, STONE scores positively related to measures of eating pathology and appearance orientation, while only weakly correlating with obsessive-compulsive tendencies. Based on its psychometric properties, STONE is recommended as a first-level screening tool for ON in research contexts and epidemiology studies among adults. Due to its brevity, it can be easily combined with other scales to explore ON or related phenomena. Future studies should examine convergent validity and test it among adolescents and in different cultural contexts. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Mitrofanova, Elina AU - Mitrofanova E AD - School of Life Sciences, Pharmacy and Chemistry, Faculty of Health, Science, Social Care and Education, Kingston University, UK; School of Human Sciences, Faculty of Education, Health, and Human Sciences, University of Greenwich, Old Royal Naval College, Park Row, Greenwich, London, SE10 9LS, UK. Electronic address: e.mitrofanova@greenwich.ac.uk. FAU - Mulrooney, Hilda AU - Mulrooney H AD - School of Life Sciences, Pharmacy and Chemistry, Faculty of Health, Science, Social Care and Education, Kingston University, UK; School of Human Sciences, London Metropolitan University, London, N78DB, UK. FAU - Pummell, Elizabeth AU - Pummell E AD - School of Life Sciences, Pharmacy and Chemistry, Faculty of Health, Science, Social Care and Education, Kingston University, UK. FAU - Petroczi, Andrea AU - Petroczi A AD - School of Life Sciences, Pharmacy and Chemistry, Faculty of Health, Science, Social Care and Education, Kingston University, UK; Faculty of Health and Sport Sciences, Szechenyi Istvan University, Gyor, Hungary. LA - eng PT - Journal Article PT - Validation Study DEP - 20250712 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - Adult MH - Reproducibility of Results MH - Male MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Young Adult MH - *Feeding Behavior/psychology MH - Adolescent MH - *Diet, Healthy/psychology MH - Factor Analysis, Statistical MH - Surveys and Questionnaires MH - Middle Aged MH - Health Behavior MH - Self Report MH - Psychometrics MH - Motivation MH - Body Image/psychology OTO - NOTNLM OT - Assessment OT - Orthorexia Nervosa OT - Psychometric scale OT - Reliability OT - Screening OT - Validity COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/07/15 00:30 MHDA- 2025/09/08 00:32 CRDT- 2025/07/14 19:35 PHST- 2025/04/13 00:00 [received] PHST- 2025/07/09 00:00 [revised] PHST- 2025/07/10 00:00 [accepted] PHST- 2025/09/08 00:32 [medline] PHST- 2025/07/15 00:30 [pubmed] PHST- 2025/07/14 19:35 [entrez] AID - S0195-6663(25)00380-0 [pii] AID - 10.1016/j.appet.2025.108227 [doi] PST - ppublish SO - Appetite. 2025 Oct 1;214:108227. doi: 10.1016/j.appet.2025.108227. Epub 2025 Jul 12. PMID- 40656946 OWN - NLM STAT- MEDLINE DCOM- 20250714 LR - 20260925 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 13 DP - 2025 TI - The effect of yoga and aerobic exercise on children's physical activity in rural India: a randomized controlled trial. PG - e19604 LID - 10.7717/peerj.19604 [doi] LID - e19604 AB - PURPOSE: This study aimed to assess the impact of yoga and aerobic exercise on moderate-to-vigorous (MVPA) levels of children in rural India. METHODS: The study utilized secondary data from a randomized, controlled, open-labelled, single-center, two-site, parallel-group trial. The study was conducted in rural India over a 6-month period between 2018-2019. Children aged 6 to 11 years were randomized into three groups: aerobic exercise (30 minutes, 5 days/week), control (no intervention), and yoga (30 minutes, 5 days/week). MVPA was measured at baseline and at six months using the Quantification of Physical Activity in School Children and Adolescents survey adapted and validated for Indian children. Overall sample and gender-segregated data were analyzed using paired sample t-tests and one-way analysis of variance with post-hoc analyses. FINDINGS: In the overall sample (N = 151), mean MVPA (minutes/day) increased significantly in both yoga (n = 50; p < 0.001) and aerobic exercise (n = 49; p < 0.001) groups from baseline to endline. Among males, mean MVPA increased significantly from baseline to endline in all three groups, including the control group (n = 23; p = 0.005). Among females, mean MVPA increased only in the yoga group, with baseline to endline change being significant across the three groups (p = 0.005), and with the yoga group depicting greater change in comparison to the control group (p = 0.004). CONCLUSIONS: Our findings suggest that both yoga and aerobic exercise can increase MVPA among rural children, with yoga being particularly beneficial for girls-a significant finding to inform culturally-appropriate active living policies to minimize the current physical activity gender gap in India. These findings can have implications for public health programs and policies not only in India but across other rural areas worldwide, where similar challenges in promoting physical activity among children may exist. CI - (c)2025 Katapally et al. FAU - Katapally, Tarun Reddy AU - Katapally TR AD - Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada. AD - DEPtH Lab, Faculty of Health Sciences, University of Western Ontario, London, Ontario, Canada. AD - Children's Health Research Institute, Lawson Health Research Institute, London, Ontario, Canada. AD - Hirabai Cowasji Jehangir Medical Research Institute, Pune, Maharashtra, India. FAU - Patel, Jamin AU - Patel J AD - Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada. AD - DEPtH Lab, Faculty of Health Sciences, University of Western Ontario, London, Ontario, Canada. FAU - Ibrahim, Sheriff Tolulope AU - Ibrahim ST AD - DEPtH Lab, Faculty of Health Sciences, University of Western Ontario, London, Ontario, Canada. AD - Children's Health Research Institute, Lawson Health Research Institute, London, Ontario, Canada. FAU - Kasture, Sonal AU - Kasture S AD - Hirabai Cowasji Jehangir Medical Research Institute, Pune, Maharashtra, India. FAU - Khadilkar, Anuradha AU - Khadilkar A AD - Hirabai Cowasji Jehangir Medical Research Institute, Pune, Maharashtra, India. FAU - Bhawra, Jasmin AU - Bhawra J AD - Hirabai Cowasji Jehangir Medical Research Institute, Pune, Maharashtra, India. AD - CHANGE Research Lab, School of Occupational and Public Health, Toronto Metropolitan University, Toronto, Ontario, Canada. LA - eng SI - figshare/10.6084/m9.figshare.25970053.v1 PT - Journal Article PT - Randomized Controlled Trial DEP - 20250708 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - *Yoga MH - India MH - Female MH - Male MH - Child MH - *Exercise MH - *Rural Population/statistics & numerical data PMC - PMC12248224 OTO - NOTNLM OT - Aerobic exercise OT - Children's health OT - Global south OT - Physical activity OT - Randomized controlled trial OT - Yoga COIS- The authors declare there are no competing interests. EDAT- 2025/07/14 12:29 MHDA- 2025/07/14 12:30 PMCR- 2025/07/08 CRDT- 2025/07/14 07:55 PHST- 2025/03/04 00:00 [received] PHST- 2025/05/23 00:00 [accepted] PHST- 2025/07/14 12:30 [medline] PHST- 2025/07/14 12:29 [pubmed] PHST- 2025/07/14 07:55 [entrez] PHST- 2025/07/08 00:00 [pmc-release] AID - 19604 [pii] AID - 10.7717/peerj.19604 [doi] PST - epublish SO - PeerJ. 2025 Jul 8;13:e19604. doi: 10.7717/peerj.19604. eCollection 2025. PMID- 40654225 OWN - NLM STAT- MEDLINE DCOM- 20250716 LR - 20260824 IS - 2047-9980 (Electronic) IS - 2047-9980 (Linking) VI - 14 IP - 14 DP - 2025 Jul 15 TI - Development and Validation of an Incident Hypertension Risk Prediction Model for Young Adults. PG - e040769 LID - 10.1161/JAHA.124.040769 [doi] LID - e040769 AB - BACKGROUND: Identifying young adults at high risk of hypertension can improve blood pressure screening recommendations. METHODS: We developed models to predict incident hypertension using diverse contemporary cohorts of young adults aged 18 to 39 years from Kaiser Permanente Southern California (derivation and internal validation) and 3 cohort studies (CARDIA [Coronary Artery Risk Development in Young Adults], FHS [Framingham Heart Study], HCHS/SOL [Hispanic Community Health Study/Study of Latinos]; external validation). Predictors included age, systolic and diastolic blood pressure, body mass index, smoking, social determinants of health, comorbidities, high- and low-density lipoprotein cholesterol, and pregnancy-related hypertensive disorders. We used Cox elastic net and random survival forests to develop sex-specific models and compared their performance to 2021 US Preventive Services Task Force blood pressure screening recommendations. RESULTS: Among 355 524 adults from Kaiser Permanente Southern California (mean age, 29 years; mean systolic/diastolic blood pressure, 115/70 mm Hg), 11.7% developed hypertension in a median of 5.4 years. External validation showed good discrimination and calibration (Harrell's C-statistic, 0.76 and 0.82; Integrated Brier Score, 0.04 and 0.02 for men and women, respectively). Compared with US Preventive Services Task Force, a 10-year risk for hypertension of >/=15% in the external cohort using the new model showed similar sensitivity (men, 0.90 versus 0.89; women, 0.81 versus 0.81) and moderate improvement in specificity (men, 0.35 versus 0.25; women, 0.66 versus 0.44). Using the National Health and Nutrition Examination Survey, the prediction model estimated 28.5 million US young adults being at high risk of hypertension compared with 45.3 million by the US Preventive Services Task Force. CONCLUSIONS: Compared with the US Preventive Services Task Force, the hypertension risk prediction model may be a more efficient tool to identify high-risk young adults for early intervention. FAU - An, Jaejin AU - An J AUID- ORCID: 0000-0002-3161-5732 AD - Department of Research & Evaluation Kaiser Permanente Southern California Pasadena CA USA. AD - Department of Health Systems Science Kaiser Permanente Bernard J. Tyson School of Medicine Pasadena CA USA. FAU - Fischer, Heidi AU - Fischer H AUID- ORCID: 0000-0001-5343-0002 AD - Department of Research & Evaluation Kaiser Permanente Southern California Pasadena CA USA. FAU - Ni, Liang AU - Ni L AD - Department of Research & Evaluation Kaiser Permanente Southern California Pasadena CA USA. FAU - Xia, Mengying AU - Xia M AUID- ORCID: 0009-0009-8866-0057 AD - Division of General Medicine Columbia University Irving Medical Center New York NY USA. FAU - Choi, Soon Kyu AU - Choi SK AUID- ORCID: 0000-0001-9160-662X AD - Department of Research & Evaluation Kaiser Permanente Southern California Pasadena CA USA. FAU - Morrissette, Kerresa L AU - Morrissette KL AUID- ORCID: 0000-0002-8333-0405 AD - Department of Research & Evaluation Kaiser Permanente Southern California Pasadena CA USA. FAU - Wei, Rong AU - Wei R AUID- ORCID: 0000-0003-0204-4982 AD - Department of Research & Evaluation Kaiser Permanente Southern California Pasadena CA USA. FAU - Reynolds, Kristi AU - Reynolds K AUID- ORCID: 0000-0001-7619-1649 AD - Department of Research & Evaluation Kaiser Permanente Southern California Pasadena CA USA. AD - Department of Health Systems Science Kaiser Permanente Bernard J. Tyson School of Medicine Pasadena CA USA. FAU - Muntner, Paul AU - Muntner P AUID- ORCID: 0000-0002-4711-5492 AD - Department of Epidemiology University of Alabama at Birmingham Birmingham AL USA. FAU - Colantonio, Lisandro D AU - Colantonio LD AUID- ORCID: 0000-0001-8742-1788 AD - Department of Epidemiology University of Alabama at Birmingham Birmingham AL USA. FAU - Moran, Andrew E AU - Moran AE AUID- ORCID: 0000-0003-3554-0085 AD - Division of General Medicine Columbia University Irving Medical Center New York NY USA. FAU - Bellows, Brandon K AU - Bellows BK AUID- ORCID: 0000-0003-1395-6047 AD - Division of General Medicine Columbia University Irving Medical Center New York NY USA. FAU - Safford, Monika M AU - Safford MM AUID- ORCID: 0000-0002-3060-0563 AD - Division of General Internal Medicine Weill Cornell Medicine New York NY USA. FAU - Allen, Norrina B AU - Allen NB AUID- ORCID: 0000-0002-6993-4384 AD - Division of Epidemiology Northwestern University Chicago IL USA. FAU - Xanthakis, Vanessa AU - Xanthakis V AUID- ORCID: 0000-0002-7352-621X AD - Department of Medicine Boston University Chobanian and Avedisian School of Medicine Boston MA USA. AD - Department of Biostatistics Boston University School of Public Health Boston MA USA. FAU - Isasi, Carmen R AU - Isasi CR AUID- ORCID: 0000-0003-2700-9593 AD - Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx NY USA. FAU - Gallo, Linda C AU - Gallo LC AUID- ORCID: 0000-0002-3678-5888 AD - Department of Psychology San Diego State University San Diego CA USA. FAU - Perreira, Krista M AU - Perreira KM AUID- ORCID: 0000-0003-2906-0261 AD - Department of Social Medicine University of North Carolina School of Medicine Chapel Hill NC USA. FAU - Zhang, Yiyi AU - Zhang Y AUID- ORCID: 0000-0002-8663-5001 AD - Division of General Medicine Columbia University Irving Medical Center New York NY USA. LA - eng GR - HHSN268201800005I/HL/NHLBI NIH HHS/United States GR - HHSN268201800007I/HL/NHLBI NIH HHS/United States GR - HHSN268201500001I/HL/NHLBI NIH HHS/United States GR - HHSN268201000001I/HL/NHLBI NIH HHS/United States GR - HHSN261201300004I/CA/NCI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Validation Study DEP - 20250714 PL - England TA - J Am Heart Assoc JT - Journal of the American Heart Association JID - 101580524 SB - IM CIN - J Am Heart Assoc. 2025 Jul 15;14(14):e042877. doi: 10.1161/JAHA.125.042877. PMID: 40654220 MH - Humans MH - Female MH - Male MH - Adult MH - *Hypertension/epidemiology/diagnosis/physiopathology MH - Risk Assessment/methods MH - Young Adult MH - Adolescent MH - California/epidemiology MH - Incidence MH - Risk Factors MH - *Blood Pressure MH - Reproducibility of Results MH - United States/epidemiology MH - Predictive Value of Tests MH - Age Factors PMC - PMC12533609 OTO - NOTNLM OT - hypertension OT - prediction model OT - young adults COIS- Dr An and Ms Choi receive research support from Bayer AG unrelated to this work. Dr Reynolds receives research support from Merck Sharp & Dohme LLC unrelated to this work. Dr Colantonio receives research support from Amgen unrelated to this work. The remaining authors have no disclosures to report. EDAT- 2025/07/14 12:29 MHDA- 2025/07/16 12:28 PMCR- 2025/07/14 CRDT- 2025/07/14 06:23 PHST- 2025/07/16 12:28 [medline] PHST- 2025/07/14 12:29 [pubmed] PHST- 2025/07/14 06:23 [entrez] PHST- 2025/07/14 00:00 [pmc-release] AID - JAH310915 [pii] AID - 10.1161/JAHA.124.040769 [doi] PST - ppublish SO - J Am Heart Assoc. 2025 Jul 15;14(14):e040769. doi: 10.1161/JAHA.124.040769. Epub 2025 Jul 14. PMID- 40653418 OWN - NLM STAT- MEDLINE DCOM- 20250826 LR - 20260802 IS - 1871-403X (Print) IS - 1871-403X (Linking) VI - 19 IP - 4 DP - 2025 Jul-Aug TI - Primary care giver and children's body-mass-index: A deep neural network model for use in primary paediatric care. PG - 356-363 LID - S1871-403X(25)00088-2 [pii] LID - 10.1016/j.orcp.2025.06.004 [doi] AB - INTRODUCTION: The familial environment is one of the major determinants of children's development of body weight during infancy and adolescence, in particular the socioeconomic status and anthropometric characteristics of the primary care giver. Thus, the aim of the present study is to utilise information on the familial environment of children and adolescents to identify an optimal prediction algorithm for estimating their expected body-mass-index (BMI) in the course of their development. METHODS: Data from Cohort '08 and Cohort '98 of the National Longitudinal Study of Children in Ireland are used (N = 37,960 and 27,499, respectively). The optimal prediction algorithm of children's BMI was identified by means of deep neural network models, with socioeconomic status and anthropometric characteristics of the primary care giver as predictors. Training and validation of the optimal model was performed with 80% and 20% of the total sample, respectively. RESULTS: The optimal deep neural network model yielded substantial improvements in prediction accuracy of children's BMI. The Pearson correlation between observed and predicted values obtained with the deep neural network was r=0.69, representing an improvement of about 50% in comparison to a simple linear model. CONCLUSION: The predicted values of deep neural network models offer acceptable accuracy to be used as a communication tool in educational prevention programmes targeting families with children at higher risk of overweight and obesity in paediatric settings. CI - Copyright (c) 2025 The Author. Published by Elsevier Ltd.. All rights reserved. FAU - Montano, Diego AU - Montano D AD - Department of Medical Sociology, Institute of the History, Philosophy and Ethics of Medicine, University of Ulm, Ulm, Oberberghof 7, 89081, Germany. Electronic address: diego.montano@uni-ulm.de. LA - eng PT - Journal Article DEP - 20250712 PL - Netherlands TA - Obes Res Clin Pract JT - Obesity research & clinical practice JID - 101303911 SB - IM MH - Humans MH - *Body Mass Index MH - Child MH - Adolescent MH - *Primary Health Care MH - Male MH - Female MH - *Neural Networks, Computer MH - Ireland/epidemiology MH - *Pediatric Obesity/epidemiology/prevention & control MH - Longitudinal Studies MH - Child, Preschool MH - Algorithms MH - Infant OTO - NOTNLM OT - Cardiovascular health prevention OT - Familial determinants of health OT - Paediatric medicine COIS- Declaration of competing interest The author has no conflict of interest to declare. EDAT- 2025/07/14 00:28 MHDA- 2025/08/31 20:04 CRDT- 2025/07/13 21:55 PHST- 2025/01/08 00:00 [received] PHST- 2025/04/27 00:00 [revised] PHST- 2025/06/27 00:00 [accepted] PHST- 2025/08/31 20:04 [medline] PHST- 2025/07/14 00:28 [pubmed] PHST- 2025/07/13 21:55 [entrez] AID - S1871-403X(25)00088-2 [pii] AID - 10.1016/j.orcp.2025.06.004 [doi] PST - ppublish SO - Obes Res Clin Pract. 2025 Jul-Aug;19(4):356-363. doi: 10.1016/j.orcp.2025.06.004. Epub 2025 Jul 12. PMID- 40650546 OWN - NLM STAT- MEDLINE DCOM- 20251008 LR - 20260917 IS - 1522-2586 (Electronic) IS - 1053-1807 (Print) IS - 1053-1807 (Linking) VI - 62 IP - 5 DP - 2025 Nov TI - Motion-Insensitive Flip Angle Modulated Liver Proton Density Fat-Fraction and R2* Mapping During Free-Breathing MRI in a Clinical Setting. PG - 1452-1463 LID - 10.1002/jmri.70033 [doi] AB - BACKGROUND: Breath-held quantitative three-dimensional chemical-shift-encoded (3D-CSE)-MRI is widely used for liver fat and iron quantification but is limited in patients unable to hold breath. Motion-insensitive two-dimensional flip angle modulated (2D-FAM) acquisitions with short temporal aperture may address this limitation. PURPOSE: To evaluate the performance of 2D-FAM-based CSE-MRI during free-breathing for quantifying proton density fat-fraction (PDFF) and R2*-based liver iron concentration (LIC). STUDY TYPE: Retrospective single-center observational analysis. POPULATION: 230 patients (110 women [47.8%], mean age 51 +/- 16 years [standard deviation, SD], range 4-85), undergoing routine clinical care between January and August 2024. FIELD STRENGTH/SEQUENCE: 1.5-T and 3.0-T, comparison of 2D-FAM-CSE-MRI under free-breathing and breath-held 3D-CSE-MRI. ASSESSMENT: Three radiologists evaluated image quality, apparent signal-to-noise ratio (SNR), and motion artifacts on a 5-point scale. PDFF and R2*-based LIC were measured in each liver segment from each acquisition. Agreement of PDFF and LIC between techniques was assessed, comparing body mass index (BMI) groups (< 30 and >/= 30 kg/m(2)). Inter-rater reliability was assessed for all analyses. STATISTICAL TESTS: Inter-rater reliability with intra-class coefficient (ICC). Bias and limits of agreement (LoA) using Bland-Altman analysis. Linear regression assessed correlations of PDFF and LIC. Receiver operating characteristic (ROC) curves (AUC) to assess diagnostic performance. Statistical significance was set at p < 0.05 (Bonferroni-corrected p < 0.01 for patient characteristics). RESULTS: 2D-FAM demonstrated superior image quality (median rating 4 vs. 3) and fewer motion artifacts (median rating 4 vs. 3) than 3D-CSE-MRI in PDFF and R2* maps. Inter-rater reliability was good to excellent (ICC 0.77-0.92). PDFF agreement was excellent (bias: +0.32%, LoA [-1.37,2.00] for BMI < 30 kg/m(2); +0.66%, [-2.44,3.76] for BMI >/= 30 kg/m(2)). LIC agreement was high (bias: -0.02 mg/g, [-0.22,0.18]) up to a threshold of 7.0 mg/g. ROC analysis showed AUC up to 1.00 for PDFF and LIC thresholds. DATA CONCLUSION: 2D-FAM CSE-MRI enables motion-insensitive liver fat and iron quantification that can be performed during free-breathing. EVIDENCE LEVEL: 2. TECHNICAL EFFICACY: Stage 2. CI - (c) 2025 The Author(s). Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine. FAU - Heidenreich, Julius F AU - Heidenreich JF AUID- ORCID: 0000-0002-0683-7982 AD - Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA. AD - Department of Diagnostic and Interventional Radiology, University Hospital Wurzburg, Germany. FAU - Tang, Jiayi AU - Tang J AUID- ORCID: 0009-0000-8565-6575 AD - Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA. AD - Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA. FAU - Tamada, Daiki AU - Tamada D AUID- ORCID: 0000-0003-3615-459X AD - Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA. FAU - Muller, Lukas AU - Muller L AD - Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA. AD - Department of Diagnostic and Interventional Radiology, University Hospital Mainz, Germany. FAU - Grunz, Jan-Peter AU - Grunz JP AUID- ORCID: 0000-0002-4524-1620 AD - Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA. AD - Department of Diagnostic and Interventional Radiology, University Hospital Wurzburg, Germany. FAU - do Vale Souza, Raphael AU - do Vale Souza R AD - Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA. FAU - Anagnostopoulos, Alexandra AU - Anagnostopoulos A AD - Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA. FAU - Pirasteh, Ali AU - Pirasteh A AUID- ORCID: 0000-0003-0797-4636 AD - Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA. FAU - Reeder, Scott B AU - Reeder SB AUID- ORCID: 0000-0003-4728-8171 AD - Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA. AD - Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA. AD - Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA. AD - Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA. AD - Department of Emergency Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA. FAU - Hernando, Diego AU - Hernando D AUID- ORCID: 0000-0002-0016-0317 AD - Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA. AD - Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA. LA - eng GR - R01 EB031886/EB/NIBIB NIH HHS/United States GR - R01EB031886/GF/NIH HHS/United States PT - Journal Article PT - Observational Study DEP - 20250712 PL - United States TA - J Magn Reson Imaging JT - Journal of magnetic resonance imaging : JMRI JID - 9105850 RN - 0 (Protons) RN - E1UOL152H7 (Iron) SB - IM MH - Humans MH - Female MH - *Magnetic Resonance Imaging/methods MH - Middle Aged MH - Male MH - *Liver/diagnostic imaging MH - Retrospective Studies MH - Adult MH - Aged MH - Respiration MH - Motion MH - Artifacts MH - Protons MH - Aged, 80 and over MH - Adolescent MH - Imaging, Three-Dimensional MH - Signal-To-Noise Ratio MH - Young Adult MH - Child MH - Reproducibility of Results MH - Adipose Tissue/diagnostic imaging MH - Iron/analysis MH - Image Interpretation, Computer-Assisted/methods MH - Image Processing, Computer-Assisted/methods PMC - PMC12456944 MID - NIHMS2111991 OTO - NOTNLM OT - CSE-MRI OT - PDFF OT - R2* OT - flip angle modulation OT - liver OT - quantification EDAT- 2025/07/13 03:35 MHDA- 2025/10/08 18:33 PMCR- 2025/10/08 CRDT- 2025/07/12 07:43 PHST- 2025/06/16 00:00 [revised] PHST- 2025/05/07 00:00 [received] PHST- 2025/06/17 00:00 [accepted] PHST- 2025/10/08 18:33 [medline] PHST- 2025/07/13 03:35 [pubmed] PHST- 2025/07/12 07:43 [entrez] PHST- 2025/10/08 00:00 [pmc-release] AID - JMRI70033 [pii] AID - 10.1002/jmri.70033 [doi] PST - ppublish SO - J Magn Reson Imaging. 2025 Nov;62(5):1452-1463. doi: 10.1002/jmri.70033. Epub 2025 Jul 12. PMID- 40650437 OWN - NLM STAT- MEDLINE DCOM- 20250712 LR - 20260925 IS - 1536-7290 (Electronic) IS - 1746-1391 (Print) IS - 1536-7290 (Linking) VI - 25 IP - 8 DP - 2025 Aug TI - The Hidden Challenge: Pelvic Floor Symptoms and Their Impact on Performance and Well-Being in Elite Female Rugby Players. PG - e70013 LID - 10.1002/ejsc.70013 [doi] LID - e70013 AB - More than half of female ball-sport athletes experience urinary leakage including 60% of Australian rugby union players. Beyond urinary incontinence (UI), the prevalence and impact of other pelvic floor (PF) symptoms in elite female athletes remains largely unknown. This study investigated PF symptom prevalence and impact on performance in elite female rugby players. A cross-sectional observational study was conducted. Australian elite female rugby players (n = 56) completed a PF questionnaire during annual medical screening. Validated questionnaires established: presence/severity of UI (ICIQ-UI SF), presence and bother of PF symptoms (PFBQ), urinary tract infection, constipation, voiding difficulty (APFQ) and pelvic pain (adapted UDI-6). Purpose-designed questions established symptom impact on performance and well-being. Data were analysed descriptively. Response/questionnaire completion rates were > 95%. Participants were on average: 22.4 years (SD: 5.9); BMI 26.3 kg/m(2) (SD: 4.6); mostly nulliparous (94%) and played 6.5 years of rugby (SD: 4.4). More than half (57%) experienced PF symptoms during sport, most commonly UI (41%). Other PF symptoms experienced during sport included: AI (29%), bladder urgency (21%)/frequency (14%) and pelvic pain (12%). One in two symptomatic players reported an impact on performance (53%) including training reductions (34%); activity avoidance (25%) and concentration loss (9%). Players restricted fluid intake to avoid provoking symptoms. A quarter of players reported PF symptoms that impacted their sports performance. This is the first study to establish that, beyond UI, AI, bladder urgency/frequency and pelvic pain are also prevalent in elite rugby players. Elite female rugby players require assessment and management of PF symptoms to maximise performance and well-being. CI - (c) 2025 The Author(s). European Journal of Sport Science published by Wiley-VCH GmbH on behalf of European College of Sport Science. FAU - Dakic, Jodie AU - Dakic J AUID- ORCID: 0000-0002-1762-1714 AD - Department of Physiotherapy, Monash University, Frankston, Australia. FAU - Perraton, Luke AU - Perraton L AD - Department of Physiotherapy, Monash University, Frankston, Australia. FAU - Lindstrom, Jessica AU - Lindstrom J AD - Department of Physiotherapy, Monash University, Frankston, Australia. FAU - Hain, Elana AU - Hain E AD - Department of Physiotherapy, Monash University, Frankston, Australia. FAU - Chuah, Shinyi AU - Chuah S AD - Department of Physiotherapy, Monash University, Frankston, Australia. FAU - Stay, Sharon AU - Stay S AD - National Tennis Academy, Tennyson, Australia. AD - Queensland Rugby Union, Herston, Australia. LA - eng PT - Journal Article PT - Observational Study PL - Germany TA - Eur J Sport Sci JT - European journal of sport science JID - 101146739 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Young Adult MH - *Football MH - *Athletic Performance/physiology MH - Adult MH - Australia/epidemiology MH - Urinary Incontinence/epidemiology MH - Athletes MH - Surveys and Questionnaires MH - Pelvic Pain/epidemiology MH - Constipation/epidemiology MH - Urinary Tract Infections/epidemiology MH - Prevalence MH - *Pelvic Floor Disorders/epidemiology MH - Adolescent MH - *Pelvic Floor/physiopathology PMC - PMC12254577 OTO - NOTNLM OT - incontinence OT - pelvic floor OT - pelvic pain OT - rugby OT - sport COIS- Dr Sharon Stay was a medical officer for Queensland Rugby Union. Dr. Jodie Dakic is a paid consultant advisor to the Hologic Women's Tennis Association Women's Health Taskforce and Labs. EDAT- 2025/07/13 03:33 MHDA- 2025/07/13 03:34 PMCR- 2025/07/12 CRDT- 2025/07/12 03:52 PHST- 2025/04/23 00:00 [revised] PHST- 2025/01/12 00:00 [received] PHST- 2025/06/24 00:00 [accepted] PHST- 2025/07/13 03:34 [medline] PHST- 2025/07/13 03:33 [pubmed] PHST- 2025/07/12 03:52 [entrez] PHST- 2025/07/12 00:00 [pmc-release] AID - EJSC70013 [pii] AID - 10.1002/ejsc.70013 [doi] PST - ppublish SO - Eur J Sport Sci. 2025 Aug;25(8):e70013. doi: 10.1002/ejsc.70013. PMID- 40650399 OWN - NLM STAT- MEDLINE DCOM- 20250712 LR - 20250712 IS - 1460-6984 (Electronic) IS - 1368-2822 (Linking) VI - 60 IP - 4 DP - 2025 Jul-Aug TI - Turkish Version of the Montreal Children's Hospital Feeding Scale: Validity and Reliability Study in Children With Cerebral Palsy. PG - e70074 LID - 10.1111/1460-6984.70074 [doi] AB - BACKGROUND: This study was conducted to translate The Montreal Children's Hospital Feeding Scale (MCH-FS) into Turkish and to evaluate the psychometric properties of the Turkish version (T-MCH-FS) in children with cerebral palsy (CP). METHOD: The study involved 160 children (70 children with CP and 90 typically developing children) aged 18 to 72 months. Karaduman Chewing Performance Scale (KCPS), Paediatric version of the Eating Assessment Tool-10 (PEDI-EAT-10) and Behavioral Pediatrics Feeding Assessment Scale (BPFAS) were used to examine the construct validity of the T-MCH-FS. RESULTS: Internal consistency was sufficient with a Cronbach's alpha value of 0.820. There were correlations between the T-MCH-FS and the KCPS (r = 0.377, p < 0.001), the PEDI-EAT-10 (r = 0.655, p < 0.001) and the BPFAS scores for total frequency, child frequency, parent frequency, restriction and poor strategies (p < 0.001). CONCLUSIONS: The T-MCH-FS was found to be a reliable and valid instrument to evaluate feeding problems in children with CP and typically developing children. WHAT THIS PAPER ADDS: What is already known on the subject Feeding problems are very common in children with CP and cause stress for the individual and their caregivers. What this paper adds to existing knowledge The MCH-FS is a practical and quick tool which provides a comprehensive overview regarding feeding problems. What are the potential or actual clinical implications of this work? The T-MCH-FS has been shown to be a reliable and valid tool for assessing feeding problems in children with CP. CI - (c) 2025 Royal College of Speech and Language Therapists. FAU - Ozun, Ozgu Inal AU - Ozun OI AUID- ORCID: 0000-0002-0351-1821 AD - Gulhane Faculty of Physiotherapy and Rehabilitation, Department of Neurologic Physiotherapy and Rehabilitation, University of Health Sciences, Ankara, Turkey. FAU - Karahan, Sevilay AU - Karahan S AUID- ORCID: 0000-0002-8692-7266 AD - Faculty of Medicine, Department of Biostatistics, Hacettepe University, Ankara, Turkey. FAU - Cemali, Mustafa AU - Cemali M AUID- ORCID: 0000-0001-7823-6628 AD - Trakya University, Faculty of Health Sciences, Department of Occupational Therapy, Edirne, Turkey. FAU - Serel Arslan, Selen AU - Serel Arslan S AUID- ORCID: 0000-0002-2463-7503 AD - Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey. LA - eng PT - Journal Article PT - Validation Study PL - United States TA - Int J Lang Commun Disord JT - International journal of language & communication disorders JID - 9803709 SB - IM MH - Humans MH - *Cerebral Palsy/complications/psychology MH - Male MH - Female MH - Reproducibility of Results MH - Psychometrics MH - Turkey MH - Child, Preschool MH - Child MH - Infant MH - *Feeding and Eating Disorders of Childhood/diagnosis/psychology/etiology MH - Translations MH - *Feeding Behavior MH - Surveys and Questionnaires MH - *Feeding and Eating Disorders/diagnosis OTO - NOTNLM OT - cerebral palsy OT - children OT - feeding behaviour OT - feeding disorders OT - parent EDAT- 2025/07/13 03:36 MHDA- 2025/07/13 03:37 CRDT- 2025/07/12 03:02 PHST- 2025/04/09 00:00 [revised] PHST- 2024/08/17 00:00 [received] PHST- 2025/05/22 00:00 [accepted] PHST- 2025/07/13 03:37 [medline] PHST- 2025/07/13 03:36 [pubmed] PHST- 2025/07/12 03:02 [entrez] AID - 10.1111/1460-6984.70074 [doi] PST - ppublish SO - Int J Lang Commun Disord. 2025 Jul-Aug;60(4):e70074. doi: 10.1111/1460-6984.70074. PMID- 40649090 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250714 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 14 IP - 13 DP - 2025 Jul 3 TI - Assessing Metabolic Syndrome Risk in Children and Adolescents with Prader-Willi Syndrome: A Comparison of Index Performance. LID - 10.3390/jcm14134716 [doi] LID - 4716 AB - Background: Currently, there is a lack of data regarding the reliability of different anthropometric, instrumental, and biochemical indexes in detecting metabolic syndrome (MetS) in pediatric patients with Prader-Willi syndrome (PWS). Therefore, this study aimed to compare the accuracy of different indices to identify the simplest and most accurate predictor of MetS in this at-risk population. Methods: We conducted a multicenter study involving 124 children and adolescents with PWS (61 males and 63 females), aged 13.6 +/- 3.7 years. For each participant, we assessed all components of MetS, defined according to either the Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS (IDEFICS) study or the International Diabetes Federation (IDF) criteria, based on age. The following indexes were calculated: Body Mass Index (BMI), BMI standard deviation score (BMI-SDS), tri-ponderal mass index, body mass fat index, fat mass index, fat-free mass index, body shape index, visceral adiposity index, waist-to-height ratio, cardiometabolic index, total cholesterol/high-density lipoprotein cholesterol (HDL-C) ratio, and triglycerides/HDL-C (TG/HDL-C) ratio. Results: MetS was identified in 24 subjects (9 females and 15 males), representing 19.4% of the sample. When comparing the receiver operating characteristic (ROC) curves, the TG/HDL-C ratio and cardiometabolic index demonstrated significantly better performance than the other indices in detecting MetS, with no difference between the two. As a result, we focused on the TG/HDL-C ratio since it is the simplest measure, requiring no additional anthropometric data compared to the cardiometabolic index. Additionally, applying age- and gender-specific thresholds can further improve its accuracy. Conclusions: The TG/HDL-C ratio, which requires only two standard biochemical markers, provides the same accuracy as more complex indexes in detecting MetS in children and adolescents with PWS, making it the optimal predictor for MetS in this population. FAU - Grugni, Graziano AU - Grugni G AUID- ORCID: 0000-0003-4708-2544 AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Piancavallo, 28824 Verbania, Italy. FAU - Lupi, Fiorenzo AU - Lupi F AD - Division of Neonatology/NICU, Hospital of Bolzano (SABES-ASDAA), Teaching Hospital of Paracelsus Medical University (PMU), 39100 Bolzano, Italy. FAU - Bonetti, Mirko AU - Bonetti M AUID- ORCID: 0000-0001-8799-181X AD - Observatory for Health-Health Department Province of Bolzano, 39100 Bolzano, Italy. FAU - Bocchini, Sarah AU - Bocchini S AD - Prader-Willi Reference Center, Endocrinology and Diabetology Unit, Bambino Gesu Children Hospital, IRCCS, 00165 Rome, Italy. FAU - Bucolo, Carmen AU - Bucolo C AD - Pediatric Unit, San Raffaele Institute, IRCCS, 20132 Milan, Italy. FAU - Corica, Domenico AU - Corica D AUID- ORCID: 0000-0002-3628-1612 AD - Pediatric Unit, Department of Human Pathology of Adulthood and Childhood "G. Barresi", University of Messina, 98124 Messina, Italy. FAU - Crino, Antonino AU - Crino A AD - Rare Disease Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00136 Rome, Italy. FAU - Faienza, Maria Felicia AU - Faienza MF AUID- ORCID: 0000-0002-1899-8337 AD - Pediatric Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari "Aldo Moro", 70124 Bari, Italy. FAU - Fintini, Danilo AU - Fintini D AD - Prader-Willi Reference Center, Endocrinology and Diabetology Unit, Bambino Gesu Children Hospital, IRCCS, 00165 Rome, Italy. FAU - Licenziati, Maria Rosaria AU - Licenziati MR AD - Neuro-Endocrine Diseases and Obesity Unit, Department of Neurosciences, Santobono-Pausilipon Children's Hospital, 80139 Naples, Italy. FAU - Maghnie, Mohamad AU - Maghnie M AUID- ORCID: 0000-0002-7183-5238 AD - Department of Pediatrics, Istituto Giannina Gaslini, IRCCS, 16147 Genova, Italy. AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, 16147 Genova, Italy. FAU - Mozzillo, Enza AU - Mozzillo E AUID- ORCID: 0000-0002-8437-8494 AD - Section of Pediatrics, Department of Translational Medical Science, Federico II University of Naples, 80131 Naples, Italy. FAU - Pajno, Roberta AU - Pajno R AUID- ORCID: 0009-0007-6406-8345 AD - Pediatric Unit, San Raffaele Institute, IRCCS, 20132 Milan, Italy. FAU - Zampino, Giuseppe AU - Zampino G AD - Rare Disease Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00136 Rome, Italy. FAU - Sartorio, Alessandro AU - Sartorio A AUID- ORCID: 0000-0002-9620-4133 AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Piancavallo, 28824 Verbania, Italy. FAU - Radetti, Giorgio AU - Radetti G AD - Marienklinik, 39100 Bolzano, Italy. CN - Genetic Obesity Group of the Italian Society of Pediatric Endocrinology and Diabetology LA - eng GR - 01C125/Italian Ministry of Health - ricerca corrente/ PT - Journal Article DEP - 20250703 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC12250793 OTO - NOTNLM OT - Prader-Willi syndrome OT - Triglycerides/HDL-Cholesterol ratio OT - metabolic syndrome COIS- The authors declare that they have no conflicts of interest that could compromise the impartiality of the research reported. EDAT- 2025/07/13 03:34 MHDA- 2025/07/13 03:35 PMCR- 2025/07/03 CRDT- 2025/07/12 01:16 PHST- 2025/04/27 00:00 [received] PHST- 2025/06/20 00:00 [revised] PHST- 2025/06/24 00:00 [accepted] PHST- 2025/07/13 03:35 [medline] PHST- 2025/07/13 03:34 [pubmed] PHST- 2025/07/12 01:16 [entrez] PHST- 2025/07/03 00:00 [pmc-release] AID - jcm14134716 [pii] AID - jcm-14-04716 [pii] AID - 10.3390/jcm14134716 [doi] PST - epublish SO - J Clin Med. 2025 Jul 3;14(13):4716. doi: 10.3390/jcm14134716. PMID- 40648770 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250714 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 14 IP - 13 DP - 2025 Jun 20 TI - Prevalence of Metabolic Syndrome Among Students: Associations with Dietary Habits, Physical Activity, and Sociodemographic Factors. LID - 10.3390/jcm14134389 [doi] LID - 4389 AB - Background/Objectives: The prevalence of metabolic syndrome (MetS) among youth is rising, and the increase is closely linked to unhealthy lifestyle patterns. This study aimed to determine the prevalence of MetS among University of Rijeka students and investigate its associations with dietary habits, physical activity, gender, and faculty type (health and non-health faculties). Methods: A cross-sectional study conducted from September 2024 to March 2025 involved 217 randomly selected students from 16 faculties. The validated questionnaires Mediterranean Diet Adherence Screener (MEDAS) and International Physical Activity Questionnaire Short Form (IPAQ-SF), as well as a general data questionnaire, were used alongside anthropometric (height, weight, waist circumference) and biochemical measurements (fasting plasma glucose, triglycerides, HDL cholesterol). MetS was diagnosed using a combination of International Diabetes Federation (IDF) criteria and Polish Experts Consensus (2022) criteria. Statistical analyses included descriptive statistics, t-tests, ANOVA, Spearman's correlation, and multivariate logistic regression. Results: MetS was identified in 5.5% of students. Significant risk factors included obesity (body mass index, BMI, p < 0.05), low physical activity (IPAQ-SF, p < 0.05), elevated blood pressure (p < 0.01), high triglyceride levels (p < 0.05), and increased waist-to-height ratio (WHtR, p < 0.01). Female students reported lower physical activity than males (p < 0.05), while students from non-health faculties had lower adherence to the Mediterranean diet (MEDAS, p < 0.05) and reduced physical activity (p < 0.05). Higher adherence to the Mediterranean diet correlated with lower BMI and triglyceride levels (p < 0.05), whereas lower adherence was associated with reduced physical activity (Spearman's r = -0.35, p < 0.01). Logistic regression with WHR as the dependent variable showed waist circumference (WC) as the strongest predictor (OR = 45.925, 95% CI: 5.238-402.666, p = 0.001), followed by triglycerides (OR = 3.395, 95% CI: 1.322-8.718, p = 0.011). BMI was inversely associated with WHR (OR = 0.068, 95% CI: 0.006-0.780, p = 0.031). HDL cholesterol, systolic and diastolic blood pressure, and fasting glucose were not significant predictors (p > 0.05), indicating limited predictive power in this model. Conclusions: The 5.5% MetS prevalence underscores the need for targeted interventions promoting Mediterranean diet adherence and physical activity, particularly among non-health faculty students and females. Longitudinal studies are warranted to assess intervention efficacy. FAU - Dejhalla, Ema AU - Dejhalla E AUID- ORCID: 0000-0003-0873-1257 AD - Medical Centre for Occupational Health, Verdieva 8, 51000 Rijeka, Croatia. AD - Depatment of Family Medicine, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia. FAU - Zavidic, Tina AU - Zavidic T AD - Depatment of Family Medicine, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia. FAU - Popovic, Branislava AU - Popovic B AD - Depatment of Family Medicine, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia. FAU - Culina, Tatjana AU - Culina T AD - Depatment of Family Medicine, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia. LA - eng PT - Journal Article DEP - 20250620 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC12249649 OTO - NOTNLM OT - diet OT - metabolic syndrome OT - physical activity OT - students COIS- The authors declare no conflicts of interest. EDAT- 2025/07/13 03:32 MHDA- 2025/07/13 03:33 PMCR- 2025/06/20 CRDT- 2025/07/12 01:14 PHST- 2025/05/18 00:00 [received] PHST- 2025/06/16 00:00 [revised] PHST- 2025/06/17 00:00 [accepted] PHST- 2025/07/13 03:33 [medline] PHST- 2025/07/13 03:32 [pubmed] PHST- 2025/07/12 01:14 [entrez] PHST- 2025/06/20 00:00 [pmc-release] AID - jcm14134389 [pii] AID - jcm-14-04389 [pii] AID - 10.3390/jcm14134389 [doi] PST - epublish SO - J Clin Med. 2025 Jun 20;14(13):4389. doi: 10.3390/jcm14134389. PMID- 40647347 OWN - NLM STAT- MEDLINE DCOM- 20250712 LR - 20250716 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 13 DP - 2025 Jul 7 TI - Diet Diversity and Adherence to a Mediterranean Diet Pattern in Pregnancy Is Protective Against the Development of Early-Childhood Atopic Dermatitis. LID - 10.3390/nu17132243 [doi] LID - 2243 AB - BACKGROUND/OBJECTIVES: The role of maternal diet in atopic dermatitis (AD) requires better understanding, as AD often manifests early in life and precedes other allergic diseases. We evaluated the association between maternal diet and AD up to 2 years of age. METHODS: A total of 116 mother-child dyads from the CARE birth cohort study were included. Maternal diet during pregnancy was assessed with a validated self-administered 97-item food frequency questionnaire, and dietary scores were calculated. AD was evaluated at ages 4 months, 1 year, and 2 years. The associations between maternal dietary patterns and AD were examined by logistic regression analysis adjusting for total energy intake, gender of the child, maternal antibiotic therapy during pregnancy, and history of atopic disease among both parents. RESULTS: Of the 116 children, 27 (23.3%) developed AD by 2 years, 11 of whom (40.7%) had persistent AD within the first 2 years. AD risk was reduced with a higher Mediterranean diet score during pregnancy (upper median > 3 points versus lower median: adjusted OR 0.24, 95% CI 0.08-0.69, p = 0.009) and with greater dietary diversity, as measured by the number of items consumed (upper median > 53 items versus lower median: OR 0.19, 95% CI 0.06-0.58, p = 0.005). No association was found with macronutrients and micronutrients. Red meat consumption showed a positive association with the persistent AD phenotype (adjusted OR 5.04, 95% CI 1.47 to 31.36, p = 0.034). CONCLUSIONS: Adherence to a Mediterranean diet and a diverse diet during pregnancy may decrease the risk of developing early childhood AD. This highlights the synergistic role of nutrients in dietary patterns as they modulate immune development and disease susceptibility. FAU - Heye, Kristina Nadine AU - Heye KN AUID- ORCID: 0000-0003-3578-9200 AD - Division of Pneumology and Allergology, Children's Hospital of Eastern Switzerland, 9006 St. Gallen, Switzerland. FAU - Bogl, Leonie Helen AU - Bogl LH AUID- ORCID: 0000-0003-4316-2619 AD - Department Nutrition and Dietetics, Faculty of Health Professions, Bern University of Applied Sciences, 3008 Bern, Switzerland. FAU - Sasaki, Mari AU - Sasaki M AD - Division of Respiratory Medicine and Allergology, Department of Pediatrics, Inselspital, University of Bern, 3010 Bern, Switzerland. FAU - Frei, Remo AU - Frei R AUID- ORCID: 0009-0007-3481-8192 AD - Division of Respiratory Medicine and Allergology, Department of Pediatrics, Inselspital, University of Bern, 3010 Bern, Switzerland. AD - Christine Kuhne-Center for Allergy Research and Education (CK-CARE), 7265 Davos, Switzerland. AD - Department of Biomedical Research, University of Bern, 3010 Bern, Switzerland. FAU - Breunig, Anna AU - Breunig A AD - Division of Pneumology and Allergology, Children's Hospital of Eastern Switzerland, 9006 St. Gallen, Switzerland. AD - Christine Kuhne-Center for Allergy Research and Education (CK-CARE), 7265 Davos, Switzerland. FAU - Buhler, Neeta AU - Buhler N AD - Division of Pneumology and Allergology, Children's Hospital of Eastern Switzerland, 9006 St. Gallen, Switzerland. AD - Christine Kuhne-Center for Allergy Research and Education (CK-CARE), 7265 Davos, Switzerland. FAU - Kahlert, Christian Raphael AU - Kahlert CR AUID- ORCID: 0000-0002-0784-3276 AD - Division of Pneumology and Allergology, Children's Hospital of Eastern Switzerland, 9006 St. Gallen, Switzerland. FAU - Goekkaya, Mehmet AU - Goekkaya M AUID- ORCID: 0000-0002-9924-9564 AD - Institute of Environmental Medicine, Helmholtz Munich-German Research Center for Environmental Health, 86156 Augsburg, Germany. AD - Institute of Environmental Medicine and Integrative Health, Faculty of Medicine, University Hospital Augsburg, 86156 Augsburg, Germany. FAU - Traidl-Hoffmann, Claudia AU - Traidl-Hoffmann C AD - Christine Kuhne-Center for Allergy Research and Education (CK-CARE), 7265 Davos, Switzerland. AD - Institute of Environmental Medicine, Helmholtz Munich-German Research Center for Environmental Health, 86156 Augsburg, Germany. AD - Institute of Environmental Medicine and Integrative Health, Faculty of Medicine, University Hospital Augsburg, 86156 Augsburg, Germany. FAU - Lauener, Roger AU - Lauener R AD - Division of Pneumology and Allergology, Children's Hospital of Eastern Switzerland, 9006 St. Gallen, Switzerland. AD - Christine Kuhne-Center for Allergy Research and Education (CK-CARE), 7265 Davos, Switzerland. FAU - Ck-Care Study Group AU - Ck-Care Study Group FAU - Roduit, Caroline AU - Roduit C AUID- ORCID: 0000-0002-5988-0570 AD - Division of Pneumology and Allergology, Children's Hospital of Eastern Switzerland, 9006 St. Gallen, Switzerland. AD - Division of Respiratory Medicine and Allergology, Department of Pediatrics, Inselspital, University of Bern, 3010 Bern, Switzerland. AD - Christine Kuhne-Center for Allergy Research and Education (CK-CARE), 7265 Davos, Switzerland. LA - eng GR - CARE study (no specific grant number)/Christine Kuhne - Center for Allergy Research and Education (CK-CARE)/ PT - Journal Article DEP - 20250707 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - *Dermatitis, Atopic/prevention & control/epidemiology MH - Pregnancy MH - *Diet, Mediterranean MH - Infant MH - Male MH - Child, Preschool MH - *Maternal Nutritional Physiological Phenomena MH - Adult MH - *Patient Compliance MH - Cohort Studies PMC - PMC12252201 OTO - NOTNLM OT - Mediterranean diet OT - atopic dermatitis OT - food diversity OT - food frequency questionnaire OT - maternal diet OT - pregnancy COIS- The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2025/07/13 03:31 MHDA- 2025/07/13 03:32 PMCR- 2025/07/07 CRDT- 2025/07/12 01:06 PHST- 2025/06/14 00:00 [received] PHST- 2025/06/30 00:00 [revised] PHST- 2025/07/03 00:00 [accepted] PHST- 2025/07/13 03:32 [medline] PHST- 2025/07/13 03:31 [pubmed] PHST- 2025/07/12 01:06 [entrez] PHST- 2025/07/07 00:00 [pmc-release] AID - nu17132243 [pii] AID - nutrients-17-02243 [pii] AID - 10.3390/nu17132243 [doi] PST - epublish SO - Nutrients. 2025 Jul 7;17(13):2243. doi: 10.3390/nu17132243. PMID- 40647284 OWN - NLM STAT- MEDLINE DCOM- 20250712 LR - 20250716 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 13 DP - 2025 Jun 30 TI - Patterns of Beverage Consumption Among Saudi Residents and Associated Demographic Factors: A Nationwide Survey. LID - 10.3390/nu17132182 [doi] LID - 2182 AB - Background/Objectives: Non-communicable diseases (NCDs) are strongly linked to beverage consumption. This study aimed to assess the average daily beverage intake of Saudi residents, energy intake from beverages, and the influence of socio-demographic factors, health behaviors, and health status on beverage intake. Methods: A nationally representative, cross-sectional study utilized stratified quota sampling to survey adults (>/=18 years) across all 13 administrative regions of Saudi Arabia. Data were collected from April 2022 to December 2023 using the validated Arabic Beverage Frequency Questionnaire (ABFQ), assessing consumption patterns of 28 beverage types. Results: The study included 4385 participants (mean age: 36.1 +/- 11.14 years, 65% male). Sweetened tea (28 mL/day), regular soft drinks (22.1 mL/day), and Saudi coffee (18 mL/day) were the most frequent beverages after water. Sweetened tea contributed to the highest average energy intake (33.2 +/- 46.4 kcal/day). Consumption of sugar-sweetened beverages (SSBs) was higher among younger individuals (18-29 years: OR: 4.0, 95% CI [2.6-6.3]; 30-44 years: OR: 2.8, 95% CI [1.8-4.3]), males (OR:1.6, 95% CI [1.4-1.8]), and residents of specific regions [Al-Jawf (OR: 1.9, 95% CI [1.2-3.2]) and Jazan (OR: 3.2, 95% CI [2.2-4.7])]. Higher water intakes were associated with males (OR: 1.5, 95% CI [1.3-1.7]), higher education levels (OR: 1.4, 95% CI [1.2-1.8]), physically active (OR: 1.5, 95% CI [1.3-1.8]), and those overweight (OR: 1.6, 95% CI [1.2-2.3]) or obese (OR: 2, 95% CI [1.4-2.8]). Conclusions: This study provides a valuable insight into beverage consumption patterns among Saudi residents. The findings highlight the need for targeted public health interventions to promote healthier beverage choices, particularly among younger populations and those with lower socioeconomic status. FAU - Alnafisah, Ruyuf Y AU - Alnafisah RY AD - Saudi Food and Drug Authority, Riyadh 13513, Saudi Arabia. FAU - Aldhirgham, Tahrir M AU - Aldhirgham TM AD - Saudi Food and Drug Authority, Riyadh 13513, Saudi Arabia. FAU - Alammari, Nouf S AU - Alammari NS AUID- ORCID: 0000-0002-2539-9922 AD - Saudi Food and Drug Authority, Riyadh 13513, Saudi Arabia. FAU - Alhadhrami, Nahlah A AU - Alhadhrami NA AUID- ORCID: 0000-0001-5019-4972 AD - Chemistry Department, Faculty of Science, Taibah University, Madinah 42353, Saudi Arabia. FAU - Alsaaydan, Safaa Abdelaziz AU - Alsaaydan SA AD - Department of Clinical Nutrition, College of Nursing and Health Sciences, Jazan University, Jazan 45142, Saudi Arabia. FAU - Alamri, Sarah M AU - Alamri SM AD - College of Science, King Khalid University, Abha 61413, Saudi Arabia. FAU - Alshamari, Mona AU - Alshamari M AD - Human Nutrition, Applied College, Hail University, Hail 55473, Saudi Arabia. FAU - Alamri, Eman AU - Alamri E AUID- ORCID: 0000-0001-5113-0495 AD - Department of Food Science and Nutrition, University of Tabuk, Tabuk 71491, Saudi Arabia. FAU - BinRowiah, Majed AU - BinRowiah M AD - Independent Researcher, Najran 61441, Saudi Arabia. FAU - Alomari, Reem Ali AU - Alomari RA AD - Department of Nutrition, College of Science, Al-Baha University, Al Bahah 65431, Saudi Arabia. FAU - Alqahtani, Amani S AU - Alqahtani AS AD - Saudi Food and Drug Authority, Riyadh 13513, Saudi Arabia. LA - eng PT - Journal Article DEP - 20250630 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Tea) SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Male MH - Adult MH - Female MH - Cross-Sectional Studies MH - Middle Aged MH - *Beverages/statistics & numerical data MH - Young Adult MH - Adolescent MH - Energy Intake MH - Health Behavior MH - Sugar-Sweetened Beverages/statistics & numerical data MH - Surveys and Questionnaires MH - *Feeding Behavior MH - Tea MH - Sociodemographic Factors MH - Socioeconomic Factors PMC - PMC12251685 OTO - NOTNLM OT - beverage OT - energy consumption OT - pattern of consumption OT - total intake COIS- The authors declare no conflicts of interest. EDAT- 2025/07/13 03:35 MHDA- 2025/07/13 03:36 PMCR- 2025/06/30 CRDT- 2025/07/12 01:06 PHST- 2025/05/14 00:00 [received] PHST- 2025/06/23 00:00 [revised] PHST- 2025/06/23 00:00 [accepted] PHST- 2025/07/13 03:36 [medline] PHST- 2025/07/13 03:35 [pubmed] PHST- 2025/07/12 01:06 [entrez] PHST- 2025/06/30 00:00 [pmc-release] AID - nu17132182 [pii] AID - nutrients-17-02182 [pii] AID - 10.3390/nu17132182 [doi] PST - epublish SO - Nutrients. 2025 Jun 30;17(13):2182. doi: 10.3390/nu17132182. PMID- 40647185 OWN - NLM STAT- MEDLINE DCOM- 20250712 LR - 20250716 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 13 DP - 2025 Jun 23 TI - Human Milk Oligosaccharide Composition at 6 Weeks Is Associated with Temperament and Eating Behaviors of Children in the STRONG Kids 2 Cohort Through 4 Years of Age. LID - 10.3390/nu17132080 [doi] LID - 2080 AB - Background/Objectives: Early childhood is a critical window of development, which is influenced by early life exposures including breastfeeding. Observational and preclinical studies have linked human milk oligosaccharides (HMOs) with neurocognitive development. However, less attention has focused on behavioral outcomes including temperament and eating behaviors. Herein, we investigated the associations between HMO consumption and child temperament and child eating behaviors through four years of age. Methods: Participants were drawn from the STRONG Kids 2 cohort. Human milk was collected at 6 weeks postpartum, and HMO relative abundances were determined by HPLC-MS. Using validated questionnaires, child temperament was assessed at 3, 18, and 48 months of age, and child eating behaviors were measured at 12, 18, 24, 36, and 48 months of age. After adjusting for covariates, multiple linear regressions were carried out to assess the relationship between HMOs and the outcome measures. Results: The HMO profile of mothers showed two distinct clusters explained by maternal secretor status. Significant associations between HMO and surgency were only found in the full cohort and secretors, while more associations between HMO and negative affectivity were observed in non-secretors. A significant number of associations was observed between HMOs and child eating behaviors in full cohort, secretors, and non-secretors. HMO diversity, total fucosylation, and total sialylation were positively associated with food responsiveness, while neutral HMOs presented negative associations. However, these associations with food responsiveness were not observed in non-secretors. Conclusions: HMO profiles were associated with behavioral outcomes in the children, with variations by child age and maternal secretor status, highlighting the potential role of HMOs within the broader context of maternal and postnatal influences. FAU - Fan, Yuting AU - Fan Y AUID- ORCID: 0000-0003-0552-5888 AD - Department of Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA. FAU - Bost, Kelly F AU - Bost KF AD - Human Development and Family Studies, Department of Human Development and Family Studies, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA. FAU - Donovan, Sharon M AU - Donovan SM AUID- ORCID: 0000-0002-9785-4189 AD - Department of Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA. AD - Division of Nutritional Science, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA. LA - eng GR - 1R01DK107561-05A1/NH/NIH HHS/United States PT - Journal Article DEP - 20250623 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Oligosaccharides) SB - IM MH - Humans MH - *Milk, Human/chemistry MH - *Temperament MH - *Oligosaccharides/analysis/chemistry MH - Female MH - Child, Preschool MH - Infant MH - Male MH - *Feeding Behavior MH - Cohort Studies MH - *Child Behavior MH - Breast Feeding MH - Adult PMC - PMC12251363 OTO - NOTNLM OT - behavioral development OT - eating behaviors OT - human milk oligosaccharides OT - temperament COIS- The authors declare no conflicts of interest. EDAT- 2025/07/13 03:36 MHDA- 2025/07/13 03:37 PMCR- 2025/06/23 CRDT- 2025/07/12 01:05 PHST- 2025/04/28 00:00 [received] PHST- 2025/06/06 00:00 [revised] PHST- 2025/06/21 00:00 [accepted] PHST- 2025/07/13 03:37 [medline] PHST- 2025/07/13 03:36 [pubmed] PHST- 2025/07/12 01:05 [entrez] PHST- 2025/06/23 00:00 [pmc-release] AID - nu17132080 [pii] AID - nutrients-17-02080 [pii] AID - 10.3390/nu17132080 [doi] PST - epublish SO - Nutrients. 2025 Jun 23;17(13):2080. doi: 10.3390/nu17132080. PMID- 40647162 OWN - NLM STAT- MEDLINE DCOM- 20250712 LR - 20250716 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 13 DP - 2025 Jun 20 TI - The Interplay Between Summer Meals, Food Insecurity, and Diet Quality Among Low-Income Children in Maryland, USA: A Multiphase Cross-Sectional Study. LID - 10.3390/nu17132055 [doi] LID - 2055 AB - Background: Food insecurity and poor diet quality disproportionately affect U.S. children from low-income households, with summer school closures exacerbating risks. Federally funded programs like the Summer Food Service Program (SFSP) and SUN Bucks (Summer EBT) aim to address these challenges, yet evidence of their post-pandemic dietary impact remains limited. Objectives: This study examines the relationship between policy innovations, summer meal participation, food insecurity, and diet quality among children from low-income households in Prince George's County, Maryland. Methods: A cross-sectional design analyzed data from 158 households in Prince George's County Public Schools across two waves (early fall 2022 and 2023). Validated tools (USDA's Six-Item Short Form and Dietary Screener Questionnaire) assessed food security and diet quality. Sociodemographic factors, program participation, and dietary deviations from the 2020-2025 Dietary Guidelines were analyzed. Multivariate logistic regression identified determinants of poor diet quality (>/=2 guideline deviations), adjusting for ethnicity, age, and housing stability. Results: Only 32.28% of eligible households participated in summer meal programs, with non-participation driven by lack of awareness (53.68%) and transportation barriers (11.58%). Significant dietary gaps included inadequate whole grain intake (0.8 vs. 3.0 servings/day) and excessive added sugars (14% of daily calories). Summer meal participation was associated with reduced odds of poor diet quality (OR = 0.23, p = 0.030), while older age (OR = 52.97, p < 0.001) and very low food security (OR = 8.42, p = 0.036) increased risk. Hispanic ethnicity had lower odds (OR = 0.17, p = 0.019) despite higher baseline food insecurity. Conclusions: Summer meal participation was associated with improved dietary outcomes but faced systemic participation barriers. Findings support policy reforms, such as multilingual outreach and mobile meal distribution, to address identified gaps. FAU - Chen, Yuyi AU - Chen Y AUID- ORCID: 0009-0000-4641-1823 AD - Graduate Group in Nutritional Biology, University of California, Davis, CA 95616, USA. FAU - Hager, Erin R AU - Hager ER AD - Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. FAU - Gross, Julia AU - Gross J AD - Maryland Hunger Solutions, Baltimore, MD 21211, USA. FAU - Gross, Susan M AU - Gross SM AUID- ORCID: 0000-0003-1589-2307 AD - Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. LA - eng GR - NA/the Bloomberg American Health Initiative, Mid-year Spark Award/ PT - Journal Article DEP - 20250620 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Food Insecurity MH - *Poverty/statistics & numerical data MH - Child MH - Female MH - Male MH - *Diet/standards/statistics & numerical data MH - *Meals MH - *Seasons MH - Maryland MH - *Food Services/statistics & numerical data MH - Child, Preschool MH - Adolescent MH - Food Assistance MH - *Food Supply MH - Food Security PMC - PMC12251470 OTO - NOTNLM OT - Summer Food Service Program OT - child nutrition OT - diet quality OT - federal nutrition programs OT - food insecurity OT - nutrition program evaluation OT - out-of-school-time nutrition OT - summer meals COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2025/07/13 03:31 MHDA- 2025/07/13 03:32 PMCR- 2025/06/20 CRDT- 2025/07/12 01:05 PHST- 2025/05/15 00:00 [received] PHST- 2025/06/06 00:00 [revised] PHST- 2025/06/11 00:00 [accepted] PHST- 2025/07/13 03:32 [medline] PHST- 2025/07/13 03:31 [pubmed] PHST- 2025/07/12 01:05 [entrez] PHST- 2025/06/20 00:00 [pmc-release] AID - nu17132055 [pii] AID - nutrients-17-02055 [pii] AID - 10.3390/nu17132055 [doi] PST - epublish SO - Nutrients. 2025 Jun 20;17(13):2055. doi: 10.3390/nu17132055. PMID- 40645012 OWN - NLM STAT- MEDLINE DCOM- 20250905 LR - 20250908 IS - 1873-6807 (Electronic) IS - 1740-1445 (Linking) VI - 54 DP - 2025 Sep TI - Psychometric properties of the Mandarin Chinese version of the thin ideal internalization assessment among young Chinese women. PG - 101939 LID - S1740-1445(25)00090-7 [pii] LID - 10.1016/j.bodyim.2025.101939 [doi] AB - The internalization of the thin ideal is closely associated with body image and eating disturbances among young Chinese women. This study aimed to examine the psychometric properties of a Chinese adaptation of the Thin Ideal Internalization Assessment (C-THIINA). Given that the original THIINA (Kidd et al., 2023) includes items related to behaviors, we simultaneously explored and compared the factor structure of the full C-THIINA and the C-THIINA deleting the behaviors (C-THIINA-D). Results of factor analysis (n = 681) showed that the 2-factor bifactor model of the C-THIINA-D had a better fit compared to all alternative models that were tested. In this model, the general factor was well-defined, but the specific factors were not, supporting the use of the global factor to conceptualize the C-THIINA-D for young Chinese women. The present study demonstrated C-THIINA-D has adequate convergent validity, concurrent validity, internal consistency reliability, and test-retest reliability among young Chinese women. Furthermore, results supported incremental validity and predictive validity of the C-THIINA-D relative to the Internalization Thin/Low Body Fat subscale of Sociocultural Attitudes Towards Appearances Questionnaire-4-Revised and the latest version of the Ideal Body Stereotype Scale. Findings suggested the C-THIINA-D is a useful instrument to measure the thin ideal internalization of young Chinese women. It can prompt further study of thin ideal internalization in China and advance knowledge about body image and eating disturbances of Chinese women. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - Lang, Min AU - Lang M AD - School of Educational Science, Chengdu Normal University, Chengdu, China. FAU - Guo, Qinglong AU - Guo Q AD - Faculty of Psychology, Southwest University, Chongqing, China. Electronic address: gql0816@foxmail.com. LA - eng PT - Journal Article DEP - 20250710 PL - Netherlands TA - Body Image JT - Body image JID - 101222431 RN - Chinese people SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Young Adult MH - *Body Image/psychology MH - China MH - Factor Analysis, Statistical MH - Psychometrics MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - *Thinness/psychology MH - East Asian People OTO - NOTNLM OT - Bifactor analysis OT - Body image OT - Chinese women OT - Predictive validity OT - Psychometric properties OT - Thin ideal internalization COIS- Declaration of Competing Interest We declare that there are no conflicts of interest in relation to the manuscript titled "Psychometric properties of the Mandarin Chinese version of the thin ideal internalization assessment among young Chinese women" submitted to Body Image. We confirm that the results and interpretations reported in the manuscript are original and have not been plagiarized. We certify that we have read and understand the Body Image conflict of interest policy, and we understand that failure to disclose a conflict of interest may result in the manuscript being rejected or retracted. We also certify that this work was supported by the Department of Scientific Research and Discipline Construction of Chengdu Normal University [grant number YJRC202312], and this study was reviewed and approved by the Chengdu Normal University Ethics Committee. All participants signed an informed consent before participating in the survey. we confirm that we have no known conflicts of interest that would influence the results or interpretation of the data presented in this manuscript. EDAT- 2025/07/12 16:44 MHDA- 2025/09/06 00:35 CRDT- 2025/07/11 18:09 PHST- 2024/12/07 00:00 [received] PHST- 2025/06/29 00:00 [revised] PHST- 2025/07/04 00:00 [accepted] PHST- 2025/09/06 00:35 [medline] PHST- 2025/07/12 16:44 [pubmed] PHST- 2025/07/11 18:09 [entrez] AID - S1740-1445(25)00090-7 [pii] AID - 10.1016/j.bodyim.2025.101939 [doi] PST - ppublish SO - Body Image. 2025 Sep;54:101939. doi: 10.1016/j.bodyim.2025.101939. Epub 2025 Jul 10. PMID- 40644951 OWN - NLM STAT- MEDLINE DCOM- 20250804 LR - 20250806 IS - 1879-3460 (Electronic) IS - 0168-1605 (Linking) VI - 441 DP - 2025 Oct 2 TI - Genomic diversity of Cronobacter sakazakii across the food system to consumers at the global scale. PG - 111335 LID - S0168-1605(25)00280-6 [pii] LID - 10.1016/j.ijfoodmicro.2025.111335 [doi] AB - Understanding how foodborne pathogens adapt to changing environments is essential for improving food safety monitoring and control. Cronobacter sakazakii, a persistent opportunistic pathogen associated with powdered infant formula outbreaks, poses critical health risks to neonates and other vulnerable populations. This study tested the hypothesis that genetic variation in C. sakazakii correlates with specific isolation sources and geographic origins across the global food system. We conducted a pangenomics meta-analysis of C. sakazakii derived from food, environmental, and clinical sources spanning North America, Asia, and Europe. A robust fine-tuned Generative Pre-trained Transformer (GPT) model was developed to standardize the categorization of isolate metadata descriptors. C. sakazakii genome assemblies (n = 748) were used to build and annotate the pangenome, and genome size and accessory gene profiles were found to be significantly associated with source type and continent of origin. Isolates from powdered foods, compared to those sourced from alternative foods, had larger genomes and were enriched in functions annotated to Clusters of Orthologous Genes (COG) category L for DNA replication, recombination and repair (e.g., transposase, integrase), among other features. Random forest models using both accessory genes and the subset of virulence factor homologs accurately predicted source attributions, identifying type VI secretion system and heavy metal response genes as key indicators of isolate origins. Several antimicrobial resistance genes associated with efflux (i.e., arlR, facT, oprZ) also exhibited patterns for biogeography. Overall, this study uncovered the distribution of key accessory genetic elements of C. sakazakii throughout the food system, revealing putative adaptations for its persistence and transmission. Our reproducible and automated workflow has potential applications in molecular surveillance for emerging food safety concerns. CI - Copyright (c) 2025 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Gao, Mairui AU - Gao M AD - Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA. FAU - Pradhan, Abani K AU - Pradhan AK AD - Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA; Center for Food Safety and Security Systems, University of Maryland, College Park, MD 20742, USA. FAU - Blaustein, Ryan A AU - Blaustein RA AD - Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA. Electronic address: rblauste@umd.edu. LA - eng PT - Journal Article PT - Meta-Analysis DEP - 20250630 PL - Netherlands TA - Int J Food Microbiol JT - International journal of food microbiology JID - 8412849 SB - IM MH - *Cronobacter sakazakii/genetics/isolation & purification/classification/drug effects MH - Humans MH - *Genetic Variation MH - *Genome, Bacterial MH - *Food Microbiology MH - Enterobacteriaceae Infections/microbiology MH - Infant Formula/microbiology OTO - NOTNLM OT - Artificial intelligence OT - Cronobacter sakazakii OT - Food safety OT - Microbial genomics OT - Pangenome COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Ryan Blaustein reports financial support was provided by National Institute of Food and Agriculture. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/07/12 16:44 MHDA- 2025/08/05 00:29 CRDT- 2025/07/11 18:07 PHST- 2025/03/27 00:00 [received] PHST- 2025/06/26 00:00 [revised] PHST- 2025/06/29 00:00 [accepted] PHST- 2025/08/05 00:29 [medline] PHST- 2025/07/12 16:44 [pubmed] PHST- 2025/07/11 18:07 [entrez] AID - S0168-1605(25)00280-6 [pii] AID - 10.1016/j.ijfoodmicro.2025.111335 [doi] PST - ppublish SO - Int J Food Microbiol. 2025 Oct 2;441:111335. doi: 10.1016/j.ijfoodmicro.2025.111335. Epub 2025 Jun 30. PMID- 40643843 OWN - NLM STAT- MEDLINE DCOM- 20250828 LR - 20250909 IS - 1865-8652 (Electronic) IS - 0741-238X (Print) IS - 0741-238X (Linking) VI - 42 IP - 9 DP - 2025 Sep TI - Development of the Pediatric Weight Questionnaire (PWQ) for Children and Adolescents with Obesity. PG - 4464-4485 LID - 10.1007/s12325-025-03277-6 [doi] AB - INTRODUCTION: Development of obesity management medications (OMMs) for use in children and adolescents calls for patient-reported outcome (PRO) measures to evaluate treatment efficacy. Existing weight-specific symptom and impact PROs are limited to age >/= 11 years and may not fully capture treatment benefit of new OMMs. METHODS: A targeted literature review was conducted to identify obesity symptom and impact outcomes and weight-specific PROs relevant to children and adolescents 6-17 years of age. Concept elicitation (CE) interviews were conducted by telephone with children and adolescents, including parents of children 6-11 years of age, to identify relevant weight-specific concepts. Key concepts relevant to three developmental age groups-6-7, 8-11, and 12-17 years-informed the creation of a pediatric weight-specific PRO to assess key symptoms and impacts of obesity: the Pediatric Weight Questionnaire (PWQ). Cognitive interviews (CI) were conducted by telephone to assess the comprehension, relevance, and comprehensiveness of the PWQ across the three age groups. RESULTS: Eight domains were identified from the literature as relevant to pediatric obesity: physical symptoms, physical function, psychological health, emotional behavior/function, family and social relationships, school functioning, and health-related quality of life. No existing weight-specific PRO encompassing these domains was identified. Twenty CE interview participants (mean age 11.4 years, 60% female, 50% Hispanic/Latino) confirmed that physical symptoms and physical, emotional, and social impacts were most relevant to their weight experience. The 23-item PWQ for adolescents 12-17 years of age and the 17-item PWQ for children 8-11 years of age are self-administered, while the 13-item PWQ for children 6-7 years of age is interviewer-administered. The three versions of the PWQ were evaluated with 34 CI participants (mean age 12 years, 64.7% female, 17.6% Hispanic/Latino), who found the PWQ easy to complete, relevant, and comprehensive. CONCLUSION: The PWQ provides a means of assessing the impact of obesity and benefits of treatment in children and adolescents 6-17 years of age with obesity. Study findings support the content validity of this new measure for use in pediatric obesity clinical trials and observational research. CI - (c) 2025. Eli Lilly and Company. FAU - Boye, Kristina S AU - Boye KS AUID- ORCID: 0000-0002-5953-5929 AD - Eli Lilly and Company, Indianapolis, IN, USA. FAU - Clark, Amy AU - Clark A AD - Evidera, Patient-Centered Research, Thermofisher, 929 North Front Street, Wilmington, NC, 28401, USA. FAU - Kanu, Chisom AU - Kanu C AUID- ORCID: 0000-0002-2621-8652 AD - Eli Lilly and Company, Indianapolis, IN, USA. FAU - Neff, Lisa M AU - Neff LM AD - Eli Lilly and Company, Indianapolis, IN, USA. FAU - Skalicky, Anne M AU - Skalicky AM AD - Evidera, Patient-Centered Research, Thermofisher, 929 North Front Street, Wilmington, NC, 28401, USA. anne.skalicky@evidera.com. LA - eng PT - Journal Article PT - Review DEP - 20250711 PL - United States TA - Adv Ther JT - Advances in therapy JID - 8611864 SB - IM MH - Humans MH - Adolescent MH - Child MH - *Pediatric Obesity/psychology/therapy MH - Female MH - Male MH - Quality of Life MH - Surveys and Questionnaires MH - *Patient Reported Outcome Measures PMC - PMC12394325 OTO - NOTNLM OT - Adolescents OT - Children OT - Content validation OT - Obesity OT - Overweight OT - Patient-reported outcome OT - Qualitative interviews OT - Quality of life COIS- Declarations. Conflicts of Interest: Anne M. Skalicky and Amy Clark are employees of Evidera, which received funding from Eli Lilly to conduct the study. Kristina Secnik Boye, Chisom Kanu, and Lisa M. Neff are employees and shareholders of Eli Lilly and Company. Ethical Approval: The CE interview protocol was approved by a US ethical central institutional review board (IRB), in accordance with local law (IRB study number WCG IRB# 20225362), and the methodology was developed in line with the FDA and the ISPOR guidance on best practice for eliciting concepts for a new PRO instrument [9, 11]. This study was also performed in accordance with the ethical principles that have their origin in the Declaration of Helsinki and that are consistent with good clinical practice and applicable regulatory requirements. Written informed consent was obtained from all participants to publish data and verbatim responses. Consent was obtained from parents and assent obtained from child and adolescent participants to publish verbatim responses. EDAT- 2025/07/11 12:30 MHDA- 2025/09/08 08:04 PMCR- 2025/07/11 CRDT- 2025/07/11 11:20 PHST- 2025/03/14 00:00 [received] PHST- 2025/06/04 00:00 [accepted] PHST- 2025/09/08 08:04 [medline] PHST- 2025/07/11 12:30 [pubmed] PHST- 2025/07/11 11:20 [entrez] PHST- 2025/07/11 00:00 [pmc-release] AID - 10.1007/s12325-025-03277-6 [pii] AID - 3277 [pii] AID - 10.1007/s12325-025-03277-6 [doi] PST - ppublish SO - Adv Ther. 2025 Sep;42(9):4464-4485. doi: 10.1007/s12325-025-03277-6. Epub 2025 Jul 11. PMID- 40643329 OWN - NLM STAT- MEDLINE DCOM- 20251210 LR - 20260607 IS - 1099-0968 (Electronic) IS - 1072-4133 (Linking) VI - 34 IP - 1 DP - 2026 Jan TI - Ecological Momentary Assessment of Impulsivity and Overeating and Loss of Control Eating in Adolescents. PG - 71-78 LID - 10.1002/erv.70010 [doi] AB - OBJECTIVES: Impulsivity has been linked to overeating and loss of control eating (LOCE), yet most adolescent research has focused on between-subjects (i.e., trait) impulsivity; thus, less is known about how within-subjects (i.e., state) impulsivity predicts overeating and LOCE. Given this gap, this study used ecological momentary assessment (EMA) to examine the construct validity of the four-item Momentary Impulsiveness Scale (MIS) in adolescents and the relationship between within- and between-subjects impulsivity and overeating and LOCE. METHODS: Seventy-four adolescents (M(age) = 15.68) completed a 10-day EMA protocol, reporting impulsivity (measured with the MIS) and eating behaviours multiple times daily. Generalised linear mixed models were run examining associations between baseline impulsivity measures and EMA impulsivity and impulsivity, disaggregated into within- and between-subjects effects, as a prospective predictor of overeating and LOCE. RESULTS: Generally, baseline impulsivity measures predicted elevated EMA impulsivity. Also, higher within-subject impulsivity significantly predicted greater LOCE and higher between-subject impulsivity was significantly associated with greater overeating and LOCE. DISCUSSION: Analyses demonstrated concordance between baseline and EMA impulsivity measures in adolescents and suggested that state impulsivity impacts the perceived control over eating. Adolescent preventions/interventions that provide strategies to reduce or mitigate state impulsivity warrant further investigation (e.g., providing in-the-moment self-regulatory strategies when feeling impulsive). CI - (c) 2025 Eating Disorders Association and John Wiley & Sons Ltd. FAU - Mason, Tyler B AU - Mason TB AUID- ORCID: 0000-0001-7284-7890 AD - Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA. FAU - Hernandez, Diego AU - Hernandez D AUID- ORCID: 0009-0000-3120-6376 AD - Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA. FAU - Morales, Jeremy C AU - Morales JC AUID- ORCID: 0000-0001-5458-031X AD - Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA. FAU - Dunton, Genevieve F AU - Dunton GF AUID- ORCID: 0000-0002-4129-3829 AD - Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA. LA - eng GR - K01DK124435/DK/NIDDK NIH HHS/United States GR - K01DK124435/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20250711 PL - England TA - Eur Eat Disord Rev JT - European eating disorders review : the journal of the Eating Disorders Association JID - 9436977 SB - IM MH - Humans MH - *Impulsive Behavior/physiology MH - Adolescent MH - *Ecological Momentary Assessment MH - Female MH - Male MH - *Hyperphagia/psychology MH - *Adolescent Behavior/psychology MH - *Feeding Behavior/psychology MH - *Self-Control/psychology OTO - NOTNLM OT - adolescents OT - binge eating OT - ecological momentary assessment OT - impulsivity EDAT- 2025/07/11 12:30 MHDA- 2025/12/10 19:21 CRDT- 2025/07/11 09:33 PHST- 2025/06/19 00:00 [revised] PHST- 2025/02/24 00:00 [received] PHST- 2025/07/04 00:00 [accepted] PHST- 2025/12/10 19:21 [medline] PHST- 2025/07/11 12:30 [pubmed] PHST- 2025/07/11 09:33 [entrez] AID - 10.1002/erv.70010 [doi] PST - ppublish SO - Eur Eat Disord Rev. 2026 Jan;34(1):71-78. doi: 10.1002/erv.70010. Epub 2025 Jul 11. PMID- 40641314 OWN - NLM STAT- MEDLINE DCOM- 20250711 LR - 20250713 IS - 2162-3279 (Electronic) VI - 15 IP - 7 DP - 2025 Jul TI - Exploring the Interplay Between Thyroid Hormone Levels and Symptoms of Anxiety and Depression in Anorexia Nervosa. PG - e70685 LID - 10.1002/brb3.70685 [doi] LID - e70685 AB - OBJECTIVE: A strong association exists between anorexia nervosa (AN) and symptoms of depression, anxiety, and obsessive-compulsive disorder (OCD). The levels of these psychiatric symptoms observed in AN may be influenced by different biological factors related to poor nutritional status and changes in thyroid hormone levels. Yet, few studies have investigated this relationship. The objective of this study is to examine the association between depression, anxiety, and obsessive-compulsive (OC) symptoms and circulating thyroid hormones in a sample of undernourished patients with AN. METHODS: Two hundred and two patients with AN (DSM-IV TR) were included in the study and were assessed upon admission for duration of illness, psychiatric treatments, sociodemographic data, and different psychopathological symptoms [depression (BDI), anxiety (HAD scale), obsessive-compulsive (MOCI), social phobia (LSAS fear sub-scale), and Eating Attitudes Test-26 (EAT-26)] using psychometric scales. Nutritional status was assessed with body mass index (BMI) and body composition using bioelectrical impedance. Upon patient admission, free-T3 (fT3), free-T4 (fT4), and TSH thyroid hormone plasma levels were collected, as well as albumin and transthyretin levels. RESULTS: Taking into consideration confounding factors, particularly the duration of AN evolution, thyroid hormone (fT3 and/or fT4) blood levels can partially explain the levels of depression and OCD symptoms of the doubt type and social phobia in undernourished AN patients. CONCLUSION: A high prevalence of these symptoms among malnourished individuals requires investigation to differentiate between symptoms directly related to the biological effects of malnutrition and those indicative of a comorbid condition such as depression or anxiety. CI - (c) 2025 The Author(s). Brain and Behavior published by Wiley Periodicals LLC. FAU - Mattar, Lama AU - Mattar L AUID- ORCID: 0000-0002-8813-1798 AD - Nutrition Program, Department of Nutrition and Food Science, School of Arts and Sciences, Lebanese American University, Beirut, Lebanon. FAU - Delaunay, Anne-Laure AU - Delaunay AL AD - Service Universitaire De Psychiatrie De L'enfant Et De L'adolescent, Centre Hospitalier de Versailles, Versailles, France. FAU - Berthoz, Sylvie AU - Berthoz S AUID- ORCID: 0000-0002-6862-2362 AD - Univ. Bordeaux, INCIA, CNRS, UMR 5287, F-33000 Bordeaux France, Bordeaux, France. AD - Department of Psychiatry for Adolescents and Young Adults, Institut Mutualiste Montsouris, Paris, France. FAU - Duquesnoy, Maeva AU - Duquesnoy M AD - Paris-Saclay University, INRAE, AgroParisTech, MICALIS Institute, Jouy-en-Josas, France. FAU - Iceta, Sylvain AU - Iceta S AD - Research Center of the Quebec Heart and Lung Institute, Quebec, QC, Canada. AD - Department of Psychiatry and Neurosciences, Laval University, Quebec, QC, Canada. FAU - Lalane, Christophe AU - Lalane C AD - Universite Paris Cite, Paris, France. CN - EVHAN group FAU - Hanachi, Mouna AU - Hanachi M AD - Clinical Nutrition department, Paul Brousse University Hospital, Assistance Publique-Hopitaux de Paris (AP-HP), Villejuif, France. AD - Paris-Saclay University, INRAE, AgroParisTech, MICALIS institute, Jouy-en-Josas, France. AD - Paris-Saclay University, Le Kremlin-Bicetre, Gif-sur-Yvette, France. FAU - Godart, Nathalie AU - Godart N AD - UFR Simone Veil, UVSQ, Montigny le Bretonneux, France. AD - Fondation Sante des Etudiants de France, Paris, France. AD - Equipe INSERM Psychiatrie du developpement, Centre de Recherche En epidemiologie et Sante Des Populations, UMR 1018, Paris-Saclay Universite, Universite Versailles-Saint- Quentin-En-Yvelines, Montigny-Le-Bretonneux, France. LA - eng PT - Journal Article PL - United States TA - Brain Behav JT - Brain and behavior JID - 101570837 RN - 0 (Thyroid Hormones) SB - IM MH - Humans MH - *Anorexia Nervosa/blood/psychology/complications MH - Female MH - *Depression/blood/complications MH - *Anxiety/blood/complications MH - *Thyroid Hormones/blood MH - Adult MH - Young Adult MH - Adolescent MH - Obsessive-Compulsive Disorder/blood MH - Malnutrition/blood MH - Nutritional Status MH - Male MH - Body Mass Index PMC - PMC12246554 OTO - NOTNLM OT - anorexia nervosa OT - anxiety OT - depression OT - malnutrition OT - obsessive-compulsive OT - thyroid hormone levels COIS- The authors declare no conflicts of interest. EDAT- 2025/07/11 06:28 MHDA- 2025/07/11 06:29 PMCR- 2025/07/11 CRDT- 2025/07/11 03:32 PHST- 2025/06/05 00:00 [revised] PHST- 2024/05/21 00:00 [received] PHST- 2025/06/20 00:00 [accepted] PHST- 2025/07/11 06:29 [medline] PHST- 2025/07/11 06:28 [pubmed] PHST- 2025/07/11 03:32 [entrez] PHST- 2025/07/11 00:00 [pmc-release] AID - BRB370685 [pii] AID - 10.1002/brb3.70685 [doi] PST - ppublish SO - Brain Behav. 2025 Jul;15(7):e70685. doi: 10.1002/brb3.70685. PMID- 40633976 OWN - NLM STAT- MEDLINE DCOM- 20250709 LR - 20250713 IS - 1600-0617 (Electronic) IS - 0905-9180 (Print) IS - 0905-9180 (Linking) VI - 34 IP - 177 DP - 2025 Jul TI - The 2025 European Cystic Fibrosis Society position statement on physical activity assessment in cystic fibrosis. LID - 10.1183/16000617.0279-2024 [doi] LID - 240279 AB - BACKGROUND: Recent advances in the measurement of physical activity have significantly enhanced the analyses and interpretation in relation to health and well-being. Thus, we sought to revise and expand the 2015 position statement on the measurement of physical activity and provide guidance to clinicians and researchers for measuring physical activity in cystic fibrosis (CF) clinical practice and research. METHODS: This study was registered with the International Prospective Register of Systematic Review (PROSPERO) database (CRD42022292165). Three databases (Medline, Embase and Cumulative Index to Nursing and Allied Health Literature) were searched for studies investigating the measurement of physical activity and sedentary time in people with CF irrespective of age or duration. The Quality Assessment for Diverse Studies was used to assess methodological concern. A mixed-methods framework synthesis was used to extract, map, chart, categorise and aggregate study findings. RESULTS: In total, 7439 potentially relevant publications were identified. Following screening of titles and abstracts, 422 full texts were retrieved and assessed for eligibility, with 90 studies included. There was considerable variation in the methods of assessment, data processing and analytical interpretation of data. CONCLUSION: It is recommended that device-based physical activity metrics are presented as time spent in different intensity categories (e.g., light, moderate and vigorous) and to include sedentary and sleep time. For data analysis, the data resolution should be at least 1 s (minimum 30 Hz) to enable clinical teams to obtain representative categorisation of patients' physical activity patterns. Validated questionnaires (e.g., the Habitual Activity Estimation Scale) offer additional opportunities to assess physical activity, whilst diaries can add context but should be viewed as secondary outcome measurements. CI - Copyright (c)The authors 2025. FAU - Williams, Craig A AU - Williams CA AD - Children's Health and Exercise Research Centre, Faculty of Health & Life Sciences, University of Exeter, Exeter, UK c.a.williams@exeter.ac.uk. FAU - Button, Brenda AU - Button B AD - Department of Respiratory Medicine, Alfred Health and Department Of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia. FAU - Dwyer, Tiffany J AU - Dwyer TJ AUID- ORCID: 0000-0001-6403-2894 AD - Discipline of Physiotherapy, School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, Australia. AD - Department of Respiratory Medicine, Royal Prince Alfred Hospital, Sydney, Australia. FAU - Hatziagorou, Elpis AU - Hatziagorou E AD - Paediatric Pulmonology and CF Unit, Hippokration General Hospital of Thessaloniki, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Mackintosh, Kelly A AU - Mackintosh KA AD - Applied Sports, Technology, Exercise and Medicine (A-STEM) Research Centre, Faculty of Science and Engineering, Swansea University, Swansea, UK. FAU - McNarry, Melitta A AU - McNarry MA AD - Applied Sports, Technology, Exercise and Medicine (A-STEM) Research Centre, Faculty of Science and Engineering, Swansea University, Swansea, UK. FAU - Paris, Dewi AU - Paris D AD - Children's Health and Exercise Research Centre, Faculty of Health & Life Sciences, University of Exeter, Exeter, UK. FAU - Shelley, James AU - Shelley J AD - School of Health and Sport Sciences, Liverpool Hope University, Liverpool, UK. FAU - Hebestreit, Helge AU - Hebestreit H AUID- ORCID: 0000-0002-9266-7149 AD - Department of Pediatrics and Center for Rare Diseases, University Hospital, Wurzburg, Germany. FAU - Bradley, Judy AU - Bradley J AD - The Wellcome Trust-Wolfson Northern Ireland Clinical Research Facility, Belfast City Hospital, and Queen University Belfast, Belfast, UK. FAU - Silveira Bianchim, Mayara AU - Silveira Bianchim M AD - School of Health Sciences, Bangor University, Bangor, UK. CN - Exercise Working Group European CF Society LA - eng PT - Journal Article PT - Practice Guideline DEP - 20250709 PL - England TA - Eur Respir Rev JT - European respiratory review : an official journal of the European Respiratory Society JID - 9111391 SB - IM MH - Adolescent MH - Adult MH - Child MH - Female MH - Humans MH - Male MH - Young Adult MH - *Actigraphy/instrumentation/standards MH - Consensus MH - *Cystic Fibrosis/physiopathology/diagnosis/therapy/psychology MH - *Exercise MH - Predictive Value of Tests MH - Sedentary Behavior MH - Time Factors MH - Systematic Reviews as Topic PMC - PMC12249234 COIS- Conflict of interest: All authors are members of the ECFS Exercise Working Group, a voluntary group that advise the society on exercise related matters for ECFS - this is all a nonpaid role. All authors have nothing further to disclose. EDAT- 2025/07/10 00:35 MHDA- 2025/07/10 00:36 PMCR- 2025/07/09 CRDT- 2025/07/09 20:53 PHST- 2024/12/11 00:00 [received] PHST- 2025/05/14 00:00 [accepted] PHST- 2025/07/10 00:36 [medline] PHST- 2025/07/10 00:35 [pubmed] PHST- 2025/07/09 20:53 [entrez] PHST- 2025/07/09 00:00 [pmc-release] AID - 34/177/240279 [pii] AID - ERR-0279-2024 [pii] AID - 10.1183/16000617.0279-2024 [doi] PST - epublish SO - Eur Respir Rev. 2025 Jul 9;34(177):240279. doi: 10.1183/16000617.0279-2024. Print 2025 Jul. PMID- 40633845 OWN - NLM STAT- MEDLINE DCOM- 20250907 LR - 20260524 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 214 DP - 2025 Oct 1 TI - Validation of a 24-item version of the child eating behavior questionnaire (CEBQ-24G) in a sample of German parents with primary school children. PG - 108223 LID - S0195-6663(25)00376-9 [pii] LID - 10.1016/j.appet.2025.108223 [doi] AB - Childhood eating behaviors significantly impact life-time health and well-being, highlighting the need for reliable measurement tools. The Child Eating Behavior Questionnaire (CEBQ) is a well-established parent-report questionnaire validated across various languages and populations. This study validates a 24-item version of the CEBQ for use in German-speaking samples. Utilizing data from a large community sample (N = 1337), we investigated the factorial structure of the CEBQ-24G through Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA). We also examined the theoretically proposed common Food Approach and Food Avoidance factors in a second-order and a bifactor model. Internal consistency was evaluated, and construct validity was assessed through bivariate correlations between the identified scales, child BMI standardized for age and sex, and External Eating and Restrained Eating from the Dutch Eating Behavior Questionnaire (DEBQ). EFA and CFA supported the original eight first-order-factor solution for the CEBQ-24G (RMSEA = 0.050 (90 % CI 0.046-0.054), CFI = 0.950, SRMR = 0.051, chi(2)(224) = 759.521, p < .001), with all items loading onto the expected subscales. The second-order model, incorporating Food Approach and Food Avoidance fit the data reasonably well (RMSEA = 0.064 (90 % CI 0.060-0.068), CFI = 0.910, SRMR = 0.098, chi(2)(243) = 1183.050, p < .001) and outperformed the bifactor model. The CEBQ-24G scales' internal consistencies were satisfactory, and correlations with weight status and DEBQ supported construct validity. In conclusion, the CEBQ-24G is a valid and efficient instrument for assessing childhood eating behaviors, including scores for second-order Food Approach and Food Avoidance factors. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Ruden, Joyce C AU - Ruden JC AD - Department of Psychology, Counseling Psychology, University of Potsdam, Potsdam, Germany. Electronic address: joyce.ruden@uni-potsdam.de. FAU - Warschburger, Petra AU - Warschburger P AD - Department of Psychology, Counseling Psychology, University of Potsdam, Potsdam, Germany. Electronic address: petra.warschburger@uni-potsdam.de. LA - eng PT - Journal Article PT - Validation Study DEP - 20250707 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - Male MH - *Feeding Behavior/psychology MH - Surveys and Questionnaires/standards MH - Child MH - Germany MH - Reproducibility of Results MH - *Parents/psychology MH - Factor Analysis, Statistical MH - *Child Behavior/psychology MH - Adult MH - Psychometrics MH - Body Mass Index OTO - NOTNLM OT - CEBQ OT - CEBQ-24G OT - Children OT - Eating behavior OT - Factorial validity OT - German OT - Validation study COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper. EDAT- 2025/07/10 00:35 MHDA- 2025/09/08 00:32 CRDT- 2025/07/09 19:36 PHST- 2024/10/16 00:00 [received] PHST- 2025/05/14 00:00 [revised] PHST- 2025/07/07 00:00 [accepted] PHST- 2025/09/08 00:32 [medline] PHST- 2025/07/10 00:35 [pubmed] PHST- 2025/07/09 19:36 [entrez] AID - S0195-6663(25)00376-9 [pii] AID - 10.1016/j.appet.2025.108223 [doi] PST - ppublish SO - Appetite. 2025 Oct 1;214:108223. doi: 10.1016/j.appet.2025.108223. Epub 2025 Jul 7. PMID- 40633266 OWN - NLM STAT- MEDLINE DCOM- 20250910 LR - 20250910 IS - 1872-7654 (Electronic) IS - 0301-2115 (Linking) VI - 313 DP - 2025 Sep TI - Weight and its impact on pelvic floor health: a cross-sectional study of parous women of reproductive and perimenopausal age. PG - 114562 LID - S0301-2115(25)00838-3 [pii] LID - 10.1016/j.ejogrb.2025.114562 [doi] AB - OBJECTIVES: Our study aimed to explore the relationship between pelvic floor dysfunction (PFD) and overweight and obesity in reproductive and perimenopausal aged women who have undergone vaginal delivery. STUDY DESIGN: In this cross-sectional study, we conducted a questionnaire-based Internet survey. The surveys were designed for parous women of reproductive and perimenopausal age (18-50 years old). We assessed their pelvic floor statues, using two validated questionnaires: USIQ and PFDI-20. We then proceeded to clinical, anthropometric and demographic questions. The combined questionnaire was submitted in both Hebrew and Arabic. We compared the prevalence of PFD symptoms in the overweight and obese group (i.e. BMI > 25) to the prevalence of the normal group (i.e. BMI 18.5-24.9). RESULTS: Between July and September 2020, 9907 women received the questionnaire. 1156 women met inclusion criteria and of them, 502 women fully completed the questionnaire (response rate 43 %). Respondents who were classified as obese or overweight exhibited more pronounced symptoms of pelvic organ prolapse and urinary distress (mean 21.5 +/- 16.3 vs. 17.0 +/- 15.8, p = 0.002). Additionally, their quality of life was more adversely affected by urinary urgency compared to the normal-weight group (mean 30.8 +/- 27.1 vs. 23.5 +/- 24.0, p = 0.022). Among the Obese group, Class three (i.e. BMI greater than 40) suffered more severe symptoms in every category. Overweight respondents experienced significantly more pelvic organ prolapse and urinary symptoms, with poorer urinary-related quality of life (p = 0.005, p = 0.042 respectively) compared to the normal weight group. CONCLUSION: In young woman who experienced vaginal delivery, increased BMI has a strong correlation to PFD, independent of age, parity and number of vaginal deliveries. Moreover, not only obesity but also being overweight alone has a direct correlation with PFD and should be highlighted by public health providers. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Fisher-Yosef, Tehila AU - Fisher-Yosef T AD - Maccabi Healthcare Services, Health Division, Tel Aviv, Israel; Gray Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel. Electronic address: fisher_t@mac.org.il. FAU - Cohen, Gal AU - Cohen G AD - The Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel; Gray Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel. FAU - Nachshon, Sapir AU - Nachshon S AD - The Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel; Gray Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel. FAU - Yagur, Yael AU - Yagur Y AD - The Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel; Gray Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel. FAU - Klein, Zvi AU - Klein Z AD - The Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel; Gray Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel. FAU - Schonman, Ron AU - Schonman R AD - The Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel; Gray Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel. FAU - Arbib, Nissim AU - Arbib N AD - The Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel; Gray Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel. FAU - Daykan, Yair AU - Daykan Y AD - The Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel; Gray Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel. LA - eng PT - Journal Article DEP - 20250704 PL - Ireland TA - Eur J Obstet Gynecol Reprod Biol JT - European journal of obstetrics, gynecology, and reproductive biology JID - 0375672 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Adult MH - Middle Aged MH - *Perimenopause/physiology MH - *Obesity/complications/epidemiology MH - *Overweight/complications/epidemiology MH - *Pelvic Floor Disorders/epidemiology/etiology MH - Young Adult MH - Adolescent MH - Surveys and Questionnaires MH - *Pelvic Floor/physiopathology MH - Body Mass Index MH - Pelvic Organ Prolapse/epidemiology MH - Prevalence MH - Parity MH - *Body Weight OTO - NOTNLM OT - Obesity OT - Overweight OT - Parity OT - Pelvic floor dysfunction OT - Reproductive-age women OT - Women health COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/07/10 00:35 MHDA- 2025/09/11 00:28 CRDT- 2025/07/09 18:05 PHST- 2025/04/25 00:00 [received] PHST- 2025/06/25 00:00 [revised] PHST- 2025/07/02 00:00 [accepted] PHST- 2025/09/11 00:28 [medline] PHST- 2025/07/10 00:35 [pubmed] PHST- 2025/07/09 18:05 [entrez] AID - S0301-2115(25)00838-3 [pii] AID - 10.1016/j.ejogrb.2025.114562 [doi] PST - ppublish SO - Eur J Obstet Gynecol Reprod Biol. 2025 Sep;313:114562. doi: 10.1016/j.ejogrb.2025.114562. Epub 2025 Jul 4. PMID- 40632823 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250718 IS - 1929-073X (Print) IS - 1929-073X (Electronic) IS - 1929-073X (Linking) VI - 14 DP - 2025 Jul 9 TI - French Versions of 2 English Questionnaires on Problematic Digital Use Assessed by Adolescents and Their Parents: Cross-Cultural Linguistic Translation and Adaptation Study. PG - e55685 LID - 10.2196/55685 [doi] LID - e55685 AB - BACKGROUND: The emergence of problematic digital use is increasingly alarming, affecting between 7% and 20% of the world's adolescent population. However, there is no validated questionnaire in French to measure this. Only a few questionnaires, either self-reported by adolescents or hetero-reported by parents, have been translated and validated in English. OBJECTIVE: This study aims to translate into French the Digital Addiction Scale for Children (DASC), which is self-reported by adolescents, and the Problematic Media Use Measure (PMUM), which is hetero-reported by parents of adolescents. METHODS: We used the "forward and backward" method to establish the translation and achieve cross-cultural adaptation with 8 parents and 8 adolescents aged between 12 and 17 years. There were three stages: (1) initial translation and synthesis or reconciliation of the translations phase; (2) back translation and expert committee phase; and (3) pretesting phase, during which 8 parents completed the PMUM questionnaire and 8 adolescents completed the DASC questionnaire. RESULTS: Despite slight variations in translation for both questionnaires, the translators quickly reached a consensus during the translation phase. The expert committee did not propose any other conceptual changes. In the final phase, the parents made no comments to improve the questions or the wording. Although some adolescents mentioned repetition between certain questions, they did not suggest any improvements to the DASC questionnaire in French. CONCLUSIONS: Although the translated versions of the DASC and PMUM questionnaires provide a foundation for detecting problematic digital use, they require further validation studies to confirm their reliability and applicability in the French adolescent population. CI - (c) Islam El Boudi, Mathilde Riant, Alexandre Bellier, Nicolas Vuillerme. Originally published in the Interactive Journal of Medical Research (https://www.i-jmr.org/). FAU - El Boudi, Islam AU - El Boudi I AUID- ORCID: 0009-0009-1992-2930 AD - Faculty of Medicine, AGEIS (Autonomie, Gerontologie, E-sante, Imagerie et Societe), Grenoble Alpes University, Jean Roget Building, 3rd Floor, Grenoble, 38000, France, 33 695685616. FAU - Riant, Mathilde AU - Riant M AUID- ORCID: 0000-0002-0780-0591 AD - Faculty of Medicine, AGEIS (Autonomie, Gerontologie, E-sante, Imagerie et Societe), Grenoble Alpes University, Jean Roget Building, 3rd Floor, Grenoble, 38000, France, 33 695685616. FAU - Bellier, Alexandre AU - Bellier A AUID- ORCID: 0000-0003-0907-0315 AD - Faculty of Medicine, AGEIS (Autonomie, Gerontologie, E-sante, Imagerie et Societe), Grenoble Alpes University, Jean Roget Building, 3rd Floor, Grenoble, 38000, France, 33 695685616. AD - Institut Universitaire de France, Paris, France. FAU - Vuillerme, Nicolas AU - Vuillerme N AUID- ORCID: 0000-0003-3773-393X AD - Faculty of Medicine, AGEIS (Autonomie, Gerontologie, E-sante, Imagerie et Societe), Grenoble Alpes University, Jean Roget Building, 3rd Floor, Grenoble, 38000, France, 33 695685616. AD - Grenoble Clinical Investigation Center (Inserm CIC 1406), Grenoble Alpes University Hospital, Grenoble Alpes University, Grenoble, France. LA - eng PT - Journal Article DEP - 20250709 PL - Canada TA - Interact J Med Res JT - Interactive journal of medical research JID - 101598421 PMC - PMC12266299 OTO - NOTNLM OT - adolescents OT - internet addiction OT - mobile phone OT - questionnaire and surveys OT - screen time OT - translations COIS- Conflicts of Interest: None declared. EDAT- 2025/07/09 18:26 MHDA- 2025/07/09 18:27 PMCR- 2025/07/09 CRDT- 2025/07/09 13:53 PHST- 2023/12/20 00:00 [received] PHST- 2025/04/10 00:00 [revised] PHST- 2025/04/22 00:00 [accepted] PHST- 2025/07/09 18:27 [medline] PHST- 2025/07/09 18:26 [pubmed] PHST- 2025/07/09 13:53 [entrez] PHST- 2025/07/09 00:00 [pmc-release] AID - v14i1e55685 [pii] AID - 55685 [pii] AID - 10.2196/55685 [doi] PST - epublish SO - Interact J Med Res. 2025 Jul 9;14:e55685. doi: 10.2196/55685. PMID- 40632783 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250718 IS - 2561-6722 (Electronic) IS - 2561-6722 (Linking) VI - 8 DP - 2025 Jul 9 TI - Empowering Caregiver Well-Being With the Adhera Caring Digital Program for Family Caregivers of Children Living With Type 1 Diabetes: Mixed Methods Feasibility Study. PG - e66914 LID - 10.2196/66914 [doi] LID - e66914 AB - BACKGROUND: Caregivers of children living with type 1 diabetes (T1D) face multiple challenges that significantly impact their mental health and quality of life. The well-being of caregivers directly affects the management of the child's condition. The Adhera Caring Digital Program (ACDP) is a comprehensive, digitally delivered program, designed to support family caregivers in enhancing self-management and well-being. This study aims to assess how the ACDP influences caregivers' mood, emotional well-being, and health-related quality of life within the context of T1D. OBJECTIVE: This study aimed to evaluate the impact of ACDP on caregivers' psychological well-being and caregiving outcomes. METHODS: This was a two-step, prospective, mixed methods study targeting caregivers of children living with T1D who were under the care of a pediatric endocrinologist at Miguel Servet Children's University Hospital in Zaragoza, Spain. In substudy 1 (SS1), qualitative and quantitative data were collected to optimize the ACDP. In substudy 2 (SS2), caregivers used the optimized ACDP for three months. Psychometric assessments were conducted at baseline and follow-up to evaluate positive mood states, general well-being, self-efficacy, and lifestyle behaviors. This paper focuses on SS2. RESULTS: Ninety caregivers participated in SS2. Positive affect significantly increased (P<.001), and negative affect decreased (P<.001) on the Positive and Negative Affect Schedule (PANAS). Depression, anxiety, and stress scores were reduced (P<.001) on the Depression, Anxiety and Stress Scale-21 Items (DASS-21). General well-being, measured by the Mental Health Continuum-Short Form (MHC-SF) and self-efficacy, assessed using General Self-Efficacy Scale (GSE), improved significantly (P<.001). Health-related quality of life (HrQoL) scores and Mediterranean Diet Quality Index scores increased modestly (P=.03, and P=.04, respectively). CONCLUSIONS: The ACDP intervention improved caregivers' psychological well-being and self-efficacy. These findings highlight the potential of digital solutions to support caregiver mental health and positively influence diabetes management. Future research should explore long-term outcomes and scalability. CI - (c) Antonio de Arriba Munoz, Elisa Civitani Monzon, Maria Pilar Ferrer, Marta Ferrer-Lozano, Silvia Quer-Palomas, Joia Nunez, Alba Xifra-Porxas, Francesca Aimee Mees Mlatiati, Ioannis Bilionis, Ricardo C Berrios, Luis Fernandez-Luque. Originally published in JMIR Pediatrics and Parenting (https://pediatrics.jmir.org). FAU - de Arriba Munoz, Antonio AU - de Arriba Munoz A AUID- ORCID: 0000-0002-2865-5813 AD - Pediatric Endocrinology Unit, Miguel Servet Children's University Hospital, Zaragoza, Spain. FAU - Civitani Monzon, Elisa AU - Civitani Monzon E AUID- ORCID: 0000-0002-2883-5769 AD - Pediatric Endocrinology Unit, Miguel Servet Children's University Hospital, Zaragoza, Spain. FAU - Ferrer, Maria Pilar AU - Ferrer MP AUID- ORCID: 0000-0002-4830-8472 AD - Pediatric Endocrinology Unit, Miguel Servet Children's University Hospital, Zaragoza, Spain. FAU - Ferrer-Lozano, Marta AU - Ferrer-Lozano M AUID- ORCID: 0000-0002-5750-7350 AD - Pediatric Endocrinology Unit, Miguel Servet Children's University Hospital, Zaragoza, Spain. FAU - Quer-Palomas, Silvia AU - Quer-Palomas S AUID- ORCID: 0000-0002-4007-8617 AD - Adhera Health Inc, 101 Cooper St., Santa Cruz, CA, 95060, United States, 1 831 345 5357. FAU - Nunez, Joia AU - Nunez J AUID- ORCID: 0000-0002-0359-6095 AD - Adhera Health Inc, 101 Cooper St., Santa Cruz, CA, 95060, United States, 1 831 345 5357. FAU - Xifra-Porxas, Alba AU - Xifra-Porxas A AUID- ORCID: 0000-0002-9023-2432 AD - Adhera Health Inc, 101 Cooper St., Santa Cruz, CA, 95060, United States, 1 831 345 5357. FAU - Aimee Mees Mlatiati, Francesca AU - Aimee Mees Mlatiati F AUID- ORCID: 0009-0005-6565-0615 AD - Adhera Health Inc, 101 Cooper St., Santa Cruz, CA, 95060, United States, 1 831 345 5357. FAU - Bilionis, Ioannis AU - Bilionis I AUID- ORCID: 0000-0002-1435-4358 AD - Adhera Health Inc, 101 Cooper St., Santa Cruz, CA, 95060, United States, 1 831 345 5357. FAU - Berrios, Ricardo C AU - Berrios RC AUID- ORCID: 0009-0008-5449-0267 AD - Adhera Health Inc, 101 Cooper St., Santa Cruz, CA, 95060, United States, 1 831 345 5357. FAU - Fernandez-Luque, Luis AU - Fernandez-Luque L AUID- ORCID: 0000-0001-8165-9904 AD - Adhera Health Inc, 101 Cooper St., Santa Cruz, CA, 95060, United States, 1 831 345 5357. LA - eng PT - Journal Article DEP - 20250709 PL - Canada TA - JMIR Pediatr Parent JT - JMIR pediatrics and parenting JID - 101727244 PMC - PMC12266296 OTO - NOTNLM OT - CGM OT - T1D OT - caregiver OT - caregiver wellbeing OT - caregiving OT - carer OT - children OT - chronic OT - coaching OT - continuous glucose monitoring OT - diabetes OT - diabetic OT - digital health OT - digital program OT - endocrinology OT - family care OT - glucose OT - guardian OT - informal care OT - parental OT - parents OT - pediatrics OT - type 1 diabetes COIS- Conflicts of Interest: AXP, IB, RCB, SQP, and LFL are current employees at Adhera Health; JN and FAMM are former employees. EDAT- 2025/07/09 18:26 MHDA- 2025/07/09 18:27 PMCR- 2025/07/09 CRDT- 2025/07/09 13:44 PHST- 2024/10/01 00:00 [received] PHST- 2025/02/19 00:00 [revised] PHST- 2025/03/18 00:00 [accepted] PHST- 2025/07/09 18:27 [medline] PHST- 2025/07/09 18:26 [pubmed] PHST- 2025/07/09 13:44 [entrez] PHST- 2025/07/09 00:00 [pmc-release] AID - v8i1e66914 [pii] AID - 66914 [pii] AID - 10.2196/66914 [doi] PST - epublish SO - JMIR Pediatr Parent. 2025 Jul 9;8:e66914. doi: 10.2196/66914. PMID- 40632382 OWN - NLM STAT- MEDLINE DCOM- 20251120 LR - 20261010 IS - 1741-0444 (Electronic) IS - 0140-0118 (Linking) VI - 63 IP - 11 DP - 2025 Nov TI - Inferring concussion history in athletes using pose and ground reaction force estimation and stability analysis of plyometric exercise videos. PG - 3461-3474 LID - 10.1007/s11517-025-03411-0 [doi] AB - Concussions present a significant risk to athletes, with females exhibiting higher rates and prolonged recovery times than males. Current sideline concussion detection methods, such as the King-Devick test commonly used as a rapid screening tool designed to evaluate eye movement, attention, language, and cognitive processing abilities suffer from validity issues. This is especially true among young athletes highlighting the need for more accurate and objective assessment tools. This study investigates the ability of the Microsoft Kinect V2 pose estimation depth sensor to reliably measure subtle postural stability differences between athletes with a history of concussion and healthy controls. Traditional methods make use of expensive force plates which require trained personnel and controlled environments, limiting their use in resource-limited settings. Inspired by previous research utilizing force plates, our study analyzes video recordings of athletes performing specific exercises to detect dynamic balance deficits. A machine learning approach is employed to predict ground reaction forces from pose estimation video recordings, which are then analyzed to measure time to stabilization. Results reveal significant differences in movement mechanics between concussed and control groups, with the drop vertical jump (DVJ) exercise demonstrating the highest discriminatory power. Notably, concussed individuals exhibit longer time to stabilization (mean difference = 0.089 s, p = 0.046) during DVJ, indicating potential lingering balance impairments. While single-leg squat (SLS) and single-leg hop (SLH) exercises showed fewer discriminatory metrics than DVJ, they still provide valuable insights into balance capabilities. The DVJ yielded the largest statistical difference between injured and healthy male athletes, while the SLH was more effective for females and the SLS, while effective for ACL rehab progress assessment, was equally ineffective for both males and females. CI - (c) 2025. International Federation for Medical and Biological Engineering. FAU - Alves, William AU - Alves W AUID- ORCID: 0009-0000-9555-4820 AD - Computer Science and Software Engineering, Concordia University, Montreal, Quebec, H3G 1M8, Canada. william.alves@mail.mcgill.ca. FAU - Babouras, Athanasios AU - Babouras A AD - Experimental Surgery, McGill University, Montreal, Quebec, H3A 0G4, Canada. FAU - Martineau, Paul A AU - Martineau PA AD - Experimental Surgery, McGill University, Montreal, Quebec, H3A 0G4, Canada. FAU - Schutt, Danielle AU - Schutt D AD - Experimental Surgery, McGill University, Montreal, Quebec, H3A 0G4, Canada. FAU - Robbins, Shawn AU - Robbins S AD - Experimental Surgery, McGill University, Montreal, Quebec, H3A 0G4, Canada. FAU - Fevens, Thomas AU - Fevens T AD - Computer Science and Software Engineering, Concordia University, Montreal, Quebec, H3G 1M8, Canada. AD - Experimental Surgery, McGill University, Montreal, Quebec, H3A 0G4, Canada. LA - eng GR - RGPIN-2020-06785/Natural Sciences and Engineering Research Council of Canada/ PT - Journal Article DEP - 20250709 PL - United States TA - Med Biol Eng Comput JT - Medical & biological engineering & computing JID - 7704869 SB - IM MH - Humans MH - *Brain Concussion/physiopathology/diagnosis MH - Male MH - Female MH - *Athletes MH - Video Recording MH - Young Adult MH - Postural Balance/physiology MH - *Plyometric Exercise/methods MH - Biomechanical Phenomena MH - Adolescent MH - Athletic Injuries/physiopathology/diagnosis MH - Adult OTO - NOTNLM OT - Computer vision OT - Concussion assessment OT - Machine learning OT - Pose estimation OT - Sports medicine COIS- Declarations. Conflict of interest: The authors declare no competing interests. EDAT- 2025/07/09 12:28 MHDA- 2025/11/20 18:28 CRDT- 2025/07/09 11:18 PHST- 2024/09/18 00:00 [received] PHST- 2025/06/30 00:00 [accepted] PHST- 2025/11/20 18:28 [medline] PHST- 2025/07/09 12:28 [pubmed] PHST- 2025/07/09 11:18 [entrez] AID - 10.1007/s11517-025-03411-0 [pii] AID - 10.1007/s11517-025-03411-0 [doi] PST - ppublish SO - Med Biol Eng Comput. 2025 Nov;63(11):3461-3474. doi: 10.1007/s11517-025-03411-0. Epub 2025 Jul 9. PMID- 40631677 OWN - NLM STAT- MEDLINE DCOM- 20250826 LR - 20250909 IS - 1942-0080 (Electronic) IS - 1941-9651 (Linking) VI - 18 IP - 8 DP - 2025 Aug TI - Z Scores for Pediatric Echocardiography Dimensions Adjusted for Body Size, BMI, and Age. PG - e017944 LID - 10.1161/CIRCIMAGING.124.017944 [doi] AB - BACKGROUND: Cardiovascular dimensions measured during pediatric echocardiograms must be normalized for body size. However, other variables may confound their interpretation, such as age and abnormal body habitus. This retrospective cross-sectional study of the Canadian Congenital and Pediatric Cardiology Research Network aimed to create Z score equations for commonly measured dimensions in pediatric 2-dimensional echocardiography that were free of residual confounding effects of body size, body mass index, and age. METHODS: The reference sample consisted of >20 000 children without heart disease from 9 institutions who underwent clinical echocardiography that was reported as normal. A generalized additive model for location, scale, and shape (GAMLSS) was used to model the expected distributions of measurements as a function of sex, height, weight, body mass index, and age. RESULTS: Compared with a model that only considered body surface area, the proposed Z scores demonstrated less bias in subgroups of overweight, young, and early school-aged children. CONCLUSIONS: The proposed Z score equations may improve diagnostic and therapeutic accuracy by ensuring that body size, body mass index, and age do not confound the interpretation of measurements. FAU - Lauzon-Schnittka, Jonathan AU - Lauzon-Schnittka J AD - Departement de Pediatrie, Universite de Sherbrooke and Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Canada (J.L.-S., V.P., F.D.). FAU - Plante, Virginie AU - Plante V AUID- ORCID: 0009-0008-5890-8835 AD - Departement de Pediatrie, Universite de Sherbrooke and Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Canada (J.L.-S., V.P., F.D.). FAU - Dahdah, Nagib AU - Dahdah N AUID- ORCID: 0000-0001-7715-3169 AD - Division of Pediatric Cardiology, Centre Hospitalier Universitaire Ste-Justine, Universite de Montreal, Quebec, Canada (N.D.). FAU - Greenway, Steven C AU - Greenway SC AUID- ORCID: 0000-0002-6981-1720 AD - Departments of Cardiac Sciences and Pediatrics, Libin Cardiovascular Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Canada (S.C.G.). FAU - Drolet, Christian AU - Drolet C AD - Division of Pediatric Cardiology, Centre Hospitalier Universitaire de Quebec, Canada (C.D.). FAU - Wong, Kenny AU - Wong K AD - Division of Cardiology, Department of Pediatrics, Izaak Walton Killam Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada (K.W.). FAU - Mackie, Andrew S AU - Mackie AS AUID- ORCID: 0000-0001-6126-1130 AD - Department of Pediatrics, University of Alberta, Edmonton, Canada (A.S.M.). FAU - Mertens, Luc AU - Mertens L AUID- ORCID: 0000-0001-7308-1268 AD - Division of Cardiology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Ontario, Canada (L.M.). FAU - Cavalle-Garrido, Tiscar AU - Cavalle-Garrido T AUID- ORCID: 0000-0003-3027-6246 AD - Division of Cardiology, Department of Pediatrics, Montreal Children's Hospital, McGill University, Canada (T.C.-G.). FAU - Penslar, Joshua AU - Penslar J AD - Department of Pediatrics, Kingston Health Sciences Center, Queen's University, Ontario, Canada (J.P.). FAU - Wong, Derek AU - Wong D AD - Department of Pediatric Cardiology, Children's Hospital of Eastern Ontario, University of Ottawa, Canada (D.W.). FAU - Garrido-Garcia, Luis Martin AU - Garrido-Garcia LM AUID- ORCID: 0000-0001-7325-8801 AD - Pediatric Cardiology Department, Hospital Angeles Lomas, Huixquilucan, Mexico (L.M.G.-G.). FAU - Dallaire, Frederic AU - Dallaire F AUID- ORCID: 0000-0002-0489-2523 AD - Departement de Pediatrie, Universite de Sherbrooke and Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Canada (J.L.-S., V.P., F.D.). CN - Canadian Congenital and Pediatric Cardiology Research Network LA - eng PT - Journal Article PT - Multicenter Study DEP - 20250709 PL - United States TA - Circ Cardiovasc Imaging JT - Circulation. Cardiovascular imaging JID - 101479935 SB - IM MH - Humans MH - Female MH - Male MH - *Body Mass Index MH - Child MH - Cross-Sectional Studies MH - Retrospective Studies MH - *Echocardiography/methods MH - *Body Size MH - Child, Preschool MH - Age Factors MH - Adolescent MH - Infant MH - Predictive Value of Tests MH - Canada MH - Reproducibility of Results OTO - NOTNLM OT - body mass index OT - echocardiography OT - obesity OT - pediatrics OT - reference values COIS- None. EDAT- 2025/07/09 12:28 MHDA- 2025/08/31 20:04 CRDT- 2025/07/09 07:43 PHST- 2025/08/31 20:04 [medline] PHST- 2025/07/09 12:28 [pubmed] PHST- 2025/07/09 07:43 [entrez] AID - 10.1161/CIRCIMAGING.124.017944 [doi] PST - ppublish SO - Circ Cardiovasc Imaging. 2025 Aug;18(8):e017944. doi: 10.1161/CIRCIMAGING.124.017944. Epub 2025 Jul 9. PMID- 40631409 OWN - NLM STAT- MEDLINE DCOM- 20250709 LR - 20260529 IS - 1520-6300 (Electronic) IS - 1042-0533 (Linking) VI - 37 IP - 7 DP - 2025 Jul TI - Validity of Adiposity Indices for Detecting High Body Fat Mass in Mexican Schoolchildren: Results From the NUTRENTO Project. PG - e70102 LID - 10.1002/ajhb.70102 [doi] AB - INTRODUCTION: Body mass index (BMI) is a known indicator of adiposity. However, alternative measures have recently been proposed in children. We aimed to evaluate the validity of alternative adiposity indices (AIs)-BMI according to the World Health Organization (BMI-WHO) and the International Obesity Task Force (BMI-IOTF) standards, waist circumference (WC), and waist-to-height ratio (WHtR)-in detecting high body fat (HBF) in Mexican schoolchildren. METHODS: This cross-sectional analysis was conducted among 2189 schoolchildren in Hidalgo, Mexico. AIs including BMI-WHO, BMI-IOTF, WC, and WHtR were evaluated via anthropometry. Body fat (BF) was assessed using bioelectrical impedance analysis (BIA). The ability of the AIs to predict HBF was evaluated using sensitivity, specificity, and confidence intervals (95% CI). Agreements between AIs and BF were analyzed using Kappa correlation coefficients and Bland-Altman plots. RESULTS: In detecting HBF, BMI-WHO showed a sensitivity of 98.2% (95% CI: 97.0-99.0) and a specificity of 59.3% (95% CI: 56.7-61.9), and WHtR showed 98.0% (95% CI: 96.6-98.8) and 57.4% (95% CI: 54.8-59.9), respectively. Among boys, moderate agreement was observed between HBF and BMI-WHO (Kappa = 0.52), WHtR (Kappa = 0.50), and WC (Kappa = 0.47), all with p < 0.001. Among girls, moderate agreement was found with BMI-WHO (Kappa = 0.45) and WHtR (Kappa = 0.41), also with p < 0.001. Bland-Altman analysis showed good agreement between HBF and WHtR and intermediate agreement with BMI-WHO. CONCLUSION: BMI-WHO and WHtR demonstrate high validity for assessing HBF in schoolchildren. WHtR may serve as a practical alternative for routine screening and for evaluating the impact of interventions aimed at reducing risks associated with excessive BF accumulation. CI - (c) 2025 Wiley Periodicals LLC. FAU - Marcos, Galvan AU - Marcos G AD - Nutritional Epidemiology Research Group (CAEPINUT), School of Health Sciences, Universidad Autonoma del Estado de Hidalgo, Pachuca, Hidalgo, Mexico. AD - Interdisciplinary Network of Experts in School Environments in Latin America, Pachuca, Hildago, Mexico. FAU - Celina, Ramirez-Ramirez AU - Celina RR AD - Nutritional Epidemiology Research Group (CAEPINUT), School of Health Sciences, Universidad Autonoma del Estado de Hidalgo, Pachuca, Hidalgo, Mexico. AD - Interdisciplinary Network of Experts in School Environments in Latin America, Pachuca, Hildago, Mexico. FAU - Guadalupe, Lopez-Rodriguez AU - Guadalupe LR AD - Nutritional Epidemiology Research Group (CAEPINUT), School of Health Sciences, Universidad Autonoma del Estado de Hidalgo, Pachuca, Hidalgo, Mexico. AD - Interdisciplinary Network of Experts in School Environments in Latin America, Pachuca, Hildago, Mexico. FAU - Luis, Martinez-Urena AU - Luis MU AD - Nutritional Epidemiology Research Group (CAEPINUT), School of Health Sciences, Universidad Autonoma del Estado de Hidalgo, Pachuca, Hidalgo, Mexico. FAU - Gabriela, Olvera-Mayorga AU - Gabriela OM AD - Nutritional Epidemiology Research Group (CAEPINUT), School of Health Sciences, Universidad Autonoma del Estado de Hidalgo, Pachuca, Hidalgo, Mexico. FAU - Patricia, Olivo-Ramirez Diana AU - Patricia OD AD - Nutritional Epidemiology Research Group (CAEPINUT), School of Health Sciences, Universidad Autonoma del Estado de Hidalgo, Pachuca, Hidalgo, Mexico. FAU - Teodoro, Suarez Dieguez AU - Teodoro SD AD - Nutritional Epidemiology Research Group (CAEPINUT), School of Health Sciences, Universidad Autonoma del Estado de Hidalgo, Pachuca, Hidalgo, Mexico. FAU - Oscar, Galvan-Valencia AU - Oscar GV AUID- ORCID: 0000-0003-3499-6822 AD - Nutritional Epidemiology Research Group (CAEPINUT), School of Health Sciences, Universidad Autonoma del Estado de Hidalgo, Pachuca, Hidalgo, Mexico. AD - Interdisciplinary Network of Experts in School Environments in Latin America, Pachuca, Hildago, Mexico. LA - eng PT - Journal Article PL - United States TA - Am J Hum Biol JT - American journal of human biology : the official journal of the Human Biology Council JID - 8915029 SB - IM MH - Humans MH - Mexico MH - Child MH - Male MH - Female MH - *Adiposity MH - Cross-Sectional Studies MH - *Body Mass Index MH - Waist Circumference MH - Adolescent MH - *Adipose Tissue MH - Anthropometry/methods MH - Sensitivity and Specificity MH - Reproducibility of Results OTO - NOTNLM OT - abdominal obesity OT - body fat OT - body mass index OT - schoolchildren OT - waist circumference EDAT- 2025/07/09 06:27 MHDA- 2025/07/09 06:28 CRDT- 2025/07/09 05:42 PHST- 2025/06/17 00:00 [revised] PHST- 2025/05/02 00:00 [received] PHST- 2025/06/23 00:00 [accepted] PHST- 2025/07/09 06:28 [medline] PHST- 2025/07/09 06:27 [pubmed] PHST- 2025/07/09 05:42 [entrez] AID - 10.1002/ajhb.70102 [doi] PST - ppublish SO - Am J Hum Biol. 2025 Jul;37(7):e70102. doi: 10.1002/ajhb.70102. PMID- 40629744 OWN - NLM STAT- MEDLINE DCOM- 20250709 LR - 20250716 IS - 1307-7945 (Electronic) IS - 1306-696X (Print) IS - 1306-696X (Linking) VI - 31 IP - 7 DP - 2025 Jul TI - Predictive value of the HALP score in differentiating complicated and uncomplicated acute appendicitis. PG - 621-626 LID - 10.14744/tjtes.2025.97198 [doi] AB - BACKGROUND: Acute appendicitis is one of the most common causes of emergency abdominal surgery, and early identification of complicated cases is critical for effective clinical management. Although classical inflammatory markers such as white blood cell count (WBC), C-reactive protein (CRP), and immature granulocyte percentage (IG%) are commonly used in diagnosis, their predictive accuracy remains limited. The HALP score (hemoglobin, albumin, lymphocyte, and platelet score), which incorporates hemoglobin, albumin, lymphocyte, and platelet levels, may offer a more comprehensive assessment by reflecting both inflammatory and immuno-nutritional status. METHODS: This retrospective study included 854 patients who underwent appendectomy between January 2022 and December 2023 at a tertiary care center. Based on surgical and pathological findings, patients were categorized into two groups: complicated and uncomplicated appendicitis. Demographic data, along with hemoglobin, albumin, lymphocyte, platelet, WBC, CRP, and IG% values, were recorded. The diagnostic performance of these parameters was statistically evaluated. RESULTS: Among the 854 patients, 112 (13.1%) were diagnosed with complicated appendicitis. Complicated cases showed a signifi-cantly higher median age and a predominance of female patients. CRP, WBC, IG%, and platelet levels were significantly elevated in the complicated group, while hemoglobin, albumin, and lymphocyte counts were lower. The HALP score was significantly lower in patients with complicated appendicitis compared to those with uncomplicated appendicitis (median: 32.8 vs. 53.4, p<0.001). Among the evalu-ated markers, the HALP score demonstrated the highest diagnostic performance (area under the curve [AUC]: 0.732), followed by CRP (AUC: 0.706), IG% (AUC: 0.645), and WBC (AUC: 0.574). CONCLUSION: The HALP score is a valuable and easily applicable biomarker for predicting complicated acute appendicitis. It outperforms traditional inflammatory markers by incorporating parameters that reflect both systemic inflammation and immuno-nutritional status. Routine use of the HALP score in emergency surgical evaluations may facilitate early identification of high-risk patients and guide clinical decision-making. Prospective, multicenter studies are needed to further validate its clinical utility. FAU - Unal, Yilmaz AU - Unal Y AD - Department of General Surgery, Ankara Training and Research Hospital, Ankara-Turkiye. FAU - Aydogdu, Yunushan Furkan AU - Aydogdu YF AD - Department of General Surgery, Ankara Training and Research Hospital, Ankara-Turkiye. FAU - Tuncal, Salih AU - Tuncal S AD - Department of General Surgery, Ankara Training and Research Hospital, Ankara-Turkiye. FAU - Barlas, Aziz Mutlu AU - Barlas AM AD - Department of General Surgery, Ankara Training and Research Hospital, Ankara-Turkiye. FAU - Balik, Recep AU - Balik R AD - Department of Infectious Diseases and Clinical Microbiology, Haydarpasa Numune Training and Research Hospital, Istanbul-Turkiye. FAU - Aydin, Recep AU - Aydin R AD - Department of General Surgery, Ankara Training and Research Hospital, Ankara-Turkiye. FAU - Simsek, Ismail AU - Simsek I AD - Department of General Surgery, Ankara Training and Research Hospital, Ankara-Turkiye. FAU - Eyol Akbulut, Tuba Gulsum AU - Eyol Akbulut TG AD - Department of General Surgery, Ankara Training and Research Hospital, Ankara-Turkiye. FAU - Tosun, Huseyin Hakan AU - Tosun HH AD - Department of General Surgery, Ankara Training and Research Hospital, Ankara-Turkiye. FAU - Kaymak, Sahin AU - Kaymak S AD - Department of General Surgery, Gulhane Training and Research Hospital, Ankara-Turkiye. LA - eng PT - Journal Article TT - Komplike ve komplike olmayan akut apandisit ayiriminda HALP skorunun ongorucu degeri. PL - Turkey TA - Ulus Travma Acil Cerrahi Derg JT - Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES JID - 101274231 RN - 0 (Biomarkers) RN - 9007-41-4 (C-Reactive Protein) RN - 0 (Hemoglobins) SB - IM MH - Humans MH - *Appendicitis/diagnosis/blood/surgery/complications MH - Female MH - Male MH - Retrospective Studies MH - Adult MH - Predictive Value of Tests MH - Middle Aged MH - Biomarkers/blood MH - C-Reactive Protein/analysis MH - Leukocyte Count MH - Appendectomy MH - Young Adult MH - Hemoglobins/analysis MH - Diagnosis, Differential MH - Platelet Count MH - Adolescent MH - Acute Disease PMC - PMC12256965 COIS- Conflict of Interest: None declared. EDAT- 2025/07/09 06:27 MHDA- 2025/07/09 06:28 PMCR- 2025/07/07 CRDT- 2025/07/09 02:13 PHST- 2025/07/09 06:28 [medline] PHST- 2025/07/09 06:27 [pubmed] PHST- 2025/07/09 02:13 [entrez] PHST- 2025/07/07 00:00 [pmc-release] AID - TJTES-31-621 [pii] AID - 10.14744/tjtes.2025.97198 [doi] PST - ppublish SO - Ulus Travma Acil Cerrahi Derg. 2025 Jul;31(7):621-626. doi: 10.14744/tjtes.2025.97198. PMID- 40629456 OWN - NLM STAT- MEDLINE DCOM- 20250709 LR - 20250711 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 13 IP - 1 DP - 2025 Jul 8 TI - Longitudinal effects of stress in an academic context on psychological well-being, physiological markers, health behaviors, and academic performance in university students. PG - 753 LID - 10.1186/s40359-025-03041-z [doi] LID - 753 AB - BACKGROUND: Stress in academic settings arises from the interplay between perceived demands such as exams, deadlines, and academic workload and an individual's coping resources. While academic stress (AS) is frequently examined as a separate construct, the stress encountered in an academic environment encompasses both academic and non-academic stressors that students face throughout their university experience. This study examined the longitudinal associations between stress in an academic context on key psychological, physiological, and behavioral variables in university students. METHODS: A longitudinal study was conducted with 115 Colombian psychology students aged 16 to 35 years, evaluated at the beginning and end of an academic semester. Variables were measured using validated psychometric questionnaires, including the Big Five inventory, the Zung Depression Scale, the UCLA Loneliness Scale, the State-Trait Anxiety Inventory (STAI), the Acceptance and Action Questionnaire (AAQ-II), the Perceived Stress Scale-4 (PSS-4). Behavioral data, such as physical activity, sleep patterns, and academic performance, were also recorded. Heart rate variability (HRV), a widely used physiological marker of autonomic nervous system function and stress regulation, was assessed. Paired t-tests were used to compare baseline and final measurements, and multiple linear regression determined predictors of academic performance. RESULTS: Longitudinal analysis revealed significant declines in sleep duration, quality, and heart rate variability (HRV), alongside increased anxiety and depressive symptoms, indicating heightened stress and autonomic dysregulation. Despite these adverse effects, academic performance improved. This pattern suggests a complex association where higher achievement coincided with declining well-being markers. Regression models identified depressive symptoms as negative predictors of performance, while greater HRV (SD1, PNN50) and balanced autonomic activity were positively associated with academic performance. CONCLUSIONS: This study examines the longitudinal effects of stress within an academic environment on the psychological, physiological, and behavioral outcomes of university students. The findings showed compromised sleep patterns, changes in autonomic regulation, and mental health indicators; nevertheless, an increase in academic performance is also noted. However, this enhancement coincides with heightened levels of anxiety, depressive symptoms, and physiological dysregulation. These results highlight the necessity for targeted interventions aimed at fostering resilience and promoting a holistic sense of well-being. CI - (c) 2025. The Author(s). FAU - Benitez-Agudelo, Juan Camilo AU - Benitez-Agudelo JC AUID- ORCID: 0000-0003-1995-1300 AD - Departamento de Ciencias Sociales, Universidad de la Costa, (Atlantico), Barranquilla, Colombia. jbenitez@cuc.edu.co. AD - Universidad Europea de Madrid, Madrid, Spain. jbenitez@cuc.edu.co. FAU - Restrepo, Dayana AU - Restrepo D AUID- ORCID: 0000-0003-2683-5893 AD - Departamento de Ciencias Sociales, Universidad de la Costa, (Atlantico), Barranquilla, Colombia. FAU - Navarro-Jimenez, Eduardo AU - Navarro-Jimenez E AUID- ORCID: 0000-0002-8171-662X AD - Facultad de Ciencias de la Salud, Universidad Simon Bolivar, Barranquilla, Colombia. FAU - Clemente-Suarez, Vicente Javier AU - Clemente-Suarez VJ AUID- ORCID: 0000-0002-2397-2801 AD - Faculty of Sports Sciences, Universidad Europea de Madrid, Madrid, Spain. AD - Grupo de Investigacion en Cultura, Educacion y Sociedad, Universidad de la Costa, (Atlantico), Barranquilla, Colombia. LA - eng PT - Journal Article DEP - 20250708 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Male MH - Female MH - Longitudinal Studies MH - *Students/psychology MH - *Stress, Psychological/physiopathology/psychology MH - Universities MH - Adult MH - Young Adult MH - Adolescent MH - *Academic Performance/psychology MH - Heart Rate/physiology MH - *Health Behavior/physiology MH - Surveys and Questionnaires MH - Anxiety/psychology/physiopathology MH - Colombia MH - Sleep/physiology MH - Depression/psychology MH - Psychological Well-Being PMC - PMC12239435 OTO - NOTNLM OT - Heart rate variability OT - Psychological flexibility OT - Sleep OT - Stress OT - University students COIS- Declarations. Ethics approval and consent to participate: All participants digitally signed an informed consent form, which outlined the study's objectives and procedures. This research adhered to the Helsinki Declaration on Human Research and was approved by the University Ethics Committee (CIPI/2024(611)). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/07/09 00:27 MHDA- 2025/07/09 06:27 PMCR- 2025/07/08 CRDT- 2025/07/09 00:00 PHST- 2024/12/12 00:00 [received] PHST- 2025/06/18 00:00 [accepted] PHST- 2025/07/09 06:27 [medline] PHST- 2025/07/09 00:27 [pubmed] PHST- 2025/07/09 00:00 [entrez] PHST- 2025/07/08 00:00 [pmc-release] AID - 10.1186/s40359-025-03041-z [pii] AID - 3041 [pii] AID - 10.1186/s40359-025-03041-z [doi] PST - epublish SO - BMC Psychol. 2025 Jul 8;13(1):753. doi: 10.1186/s40359-025-03041-z. PMID- 40629310 OWN - NLM STAT- MEDLINE DCOM- 20250709 LR - 20250711 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Jul 8 TI - Are more muscle-strengthening exercise participations associated with weight status in children and adolescents? Results from 67,281 participants. PG - 2408 LID - 10.1186/s12889-025-23556-9 [doi] LID - 2408 AB - PURPOSE: The aim of this study was to explore association between muscle-strengthening exercise (MSE) days and weight status in Chinese children and adolescents. METHODS: Cross-sectional data of 67,281 Chinese adolescents aged 10-17 years (mean age = 13.0 years, 51.9% males) was collected using online questionnaires. Validated questionnaires were used to collected data on variables (days of MES and weight status, sociodemographic characteristics) of interest in this study. The Chinese Children and Adolescents Weight Status Workforce Standard was used to categorize weight status into three groups: non-overweight/obesity, overweight, and obesity. A series of multilevel generalized linear models were used to analyse associations between days of MSE and weight status. Results were presented as odds ratio (OR) with 95% confidence interval (CI). RESULTS: In total, 34,909 boys (51.9%) and 32,372 girls (48.1%), respectively, were included in the current study. In the overall sample, those who engaged in MSE for 2 or more days had lower odds of overweight and obesity (p for trend < 0.001; OR for 2 days: 0.88, 95%CI: 0.84-0.93; OR for 3 days: 0.91, 95% CI: 0.86-0.96; OR for 4 days: 0.79, 95%CI: 0.74-0.85; OR for 5 days: 0.82, 95%CI: 0.76-0.88; OR 6 days: 0.69, 95%CI: 0.60-0.79; OR for 7 days: 0.71, 95%CI: 0.66-0.77). The associations between MSE and weight status were more pronounced in boys and younger participants. However, there was no clear pattern between MSE days and weight status among high school students. Results on subgroup analyses showed inverse associations between days of engaging in MSE per week and overweight and obesity in those not meeting the physical activity guidelines, except for girls (p = 0.179) and high school students (p = 0.449). CONCLUSIONS: More days of MSE participation may be a protective factor that can prevent or control overweight and obesity in children and adolescents. However, given the study limitations in nature, future studies are recommended to confirm the association between MSE and weight status. CI - (c) 2025. The Author(s). FAU - Su, Huadong AU - Su H AD - Future National Fitness Research Institute, Zhejiang Normal University, Jinhua, China. AD - Faculty of Medicine, Veterinary Medicine, and Life Sciences, University of Glasgow, Glasgow City, UK. FAU - Chi, Xinli AU - Chi X AD - School of Psychology, Shenzhen University, Shenzhen, China. AD - Centre for Mental Health, Shenzhen University, Shenzhen, China. FAU - Li, Hui AU - Li H AD - Future National Fitness Research Institute, Zhejiang Normal University, Jinhua, China. jmclh@zjnu.edu.cn. FAU - Du, Songjian AU - Du S AD - School of Physical Education and Sports Science, Soochow University, Suzhou, China. FAU - Yan, Jin AU - Yan J AD - School of Physical Education and Sports Science, Soochow University, Suzhou, China. jinyan1126@suda.edu.cn. LA - eng PT - Journal Article DEP - 20250708 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - Child MH - Cross-Sectional Studies MH - *Exercise/physiology MH - China/epidemiology MH - Surveys and Questionnaires MH - *Overweight/prevention & control/epidemiology MH - *Muscle Strength/physiology MH - *Body Weight MH - Pediatric Obesity/prevention & control MH - *Resistance Training/statistics & numerical data PMC - PMC12235924 OTO - NOTNLM OT - Muscle-strengthening activity OT - Physical activity OT - School-aged student OT - Weight status COIS- Declarations. Ethics approval and consent to participate: The permission to conduct this study was obtained from the teachers and principals of those participating schools. All the children and adolescents participating in the study, and their parents or guardians, were informed and participants voluntarily took part in this survey. Verbal informed consent was obtained from all parents/guardians or teachers, and positive assent was obtained from all the children before data collection which was approved by the Institution of Review Board at Shenzhen University. This study survey was also approved by the Institution of Review Board at Shenzhen University (No. 2020005). Procedures performed in studies were by the national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Data were collected and analyzed anonymously. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/07/09 00:27 MHDA- 2025/07/09 06:27 PMCR- 2025/07/08 CRDT- 2025/07/08 23:53 PHST- 2024/06/11 00:00 [received] PHST- 2025/06/10 00:00 [accepted] PHST- 2025/07/09 06:27 [medline] PHST- 2025/07/09 00:27 [pubmed] PHST- 2025/07/08 23:53 [entrez] PHST- 2025/07/08 00:00 [pmc-release] AID - 10.1186/s12889-025-23556-9 [pii] AID - 23556 [pii] AID - 10.1186/s12889-025-23556-9 [doi] PST - epublish SO - BMC Public Health. 2025 Jul 8;25(1):2408. doi: 10.1186/s12889-025-23556-9. PMID- 40629280 OWN - NLM STAT- MEDLINE DCOM- 20250709 LR - 20260619 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 25 IP - 1 DP - 2025 Jul 9 TI - Sleep among Brazilian adolescents before and after the COVID-19 pandemic: repeated cross-sectional and longitudinal analyses. PG - 541 LID - 10.1186/s12887-025-05904-1 [doi] LID - 541 AB - BACKGROUND: The COVID-19 pandemic significantly disrupted adolescents' routines, including their sleep patterns, due to school closures, social isolation, and increased screen time. As routines normalized post-pandemic, understanding whether these changes persisted or reverted to pre-pandemic levels is essential. OBJECTIVE: To compare sleep variables between the periods before and after the COVID-19 pandemic in samples of Brazilian adolescents. METHODS: A repeated cross-sectional study with a nested cohort targeting high-school students from Southern Brazil was used. Different sleep variables were obtained from wrist-worn accelerometers and validated questionnaires. Generalized linear mixed models with Gaussian distribution and identity link function were used to compare sleep variables between the survey years. RESULTS: In 2019, 674 adolescents participated (51.8% female, mean age = 16.3, SD = 1.1), and in 2022, 625 participated (56.3% female, mean age = 16.5, SD = 1.2). In the longitudinal sample, 242 out of 333 eligible participants provided complete data in 2019, and 138 out of 286 agreed to participate in 2022. Cross-sectional data indicate significant differences for social jet lag (beta: -0.28, p < 0.001) and self-reported sleep duration (beta: -0.14, p = 0.03) between 2019 and 2022. Prospective data indicate significant changes for sleep regularity (beta: -4.27, p < 0.001), daytime sleepiness (beta: 1.05, p = 0.01), catch-up sleep (beta: -0.35, p = 0.04) and self-reported sleep duration (beta: -0.42, p < 0.001). However, effect sizes were all small. CONCLUSION: Our findings suggest that adolescent sleep characteristics in Brazil post-COVID-19 are similar to pre-pandemic levels, indicating that the initial impact of the pandemic on sleep did not persist after routines normalized. CI - (c) 2025. The Author(s). FAU - Maciel, Gabriel Pereira AU - Maciel GP AUID- ORCID: 0000-0002-4141-1995 AD - Department of Physical Education, Federal University of Santa Catarina, Florianopolis, 88040-900, Brazil. gabrielpmaciel12@gmail.com. FAU - de Camargo, Ricardo AU - de Camargo R AUID- ORCID: 0000-0003-2701-347X AD - Department of Physical Education, Federal University of Santa Catarina, Florianopolis, 88040-900, Brazil. FAU - Lopes, Marcus Vinicius Veber AU - Lopes MVV AUID- ORCID: 0000-0002-7968-5211 AD - Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada. FAU - de Oliveira, Bruno Nunes AU - de Oliveira BN AUID- ORCID: 0000-0001-5757-2075 AD - Department of Physical Education, Federal University of Santa Catarina, Florianopolis, 88040-900, Brazil. FAU - da Costa, Bruno Galdino Goncalves AU - da Costa BGG AUID- ORCID: 0000-0002-5132-1512 AD - Department of Kinesiology and Physical Education, McGill University, Montreal, Canada. FAU - Chaput, Jean-Philippe AU - Chaput JP AUID- ORCID: 0000-0002-5607-5736 AD - Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada. FAU - Silva, Kelly Samara AU - Silva KS AUID- ORCID: 0000-0002-7356-1680 AD - Department of Physical Education, Federal University of Santa Catarina, Florianopolis, 88040-900, Brazil. LA - eng GR - Finance code 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ GR - Finance code 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ GR - Finance code 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ GR - Finance code 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ GR - 305803/2020-4/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/ PT - Journal Article DEP - 20250709 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Female MH - Adolescent MH - *COVID-19/epidemiology MH - Cross-Sectional Studies MH - Brazil/epidemiology MH - Male MH - Longitudinal Studies MH - *Sleep MH - Pandemics MH - Surveys and Questionnaires MH - SARS-CoV-2 PMC - PMC12239257 OTO - NOTNLM OT - Accelerometry OT - Sleep efficiency OT - Sleep timing OT - Sleep-related behaviors OT - Sleepiness OT - Youth COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the ethical standards of the institutional and national research committees and with the 1964 Helsinki Declaration and its later amendments. The project was approved by the Human Research Ethics Committee of the Federal University of Santa Catarina under protocol number 3,168,745. Informed consent was obtained from all individual participants included in the study. For participants who were minors (under the age of 18), consent was obtained from their parents or legal guardians. Additionally, assent was sought from the minors themselves after providing them with age-appropriate information about the study. Participants were informed about the study's objectives, procedures, potential risks, and benefits, and they were given the opportunity to ask questions. Consent and assent were given voluntarily, and participants and their guardians were informed of their right to withdraw from the study at any time without any consequences. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/07/09 00:27 MHDA- 2025/07/09 06:26 PMCR- 2025/07/09 CRDT- 2025/07/08 23:51 PHST- 2024/12/19 00:00 [received] PHST- 2025/06/24 00:00 [accepted] PHST- 2025/07/09 06:26 [medline] PHST- 2025/07/09 00:27 [pubmed] PHST- 2025/07/08 23:51 [entrez] PHST- 2025/07/09 00:00 [pmc-release] AID - 10.1186/s12887-025-05904-1 [pii] AID - 5904 [pii] AID - 10.1186/s12887-025-05904-1 [doi] PST - epublish SO - BMC Pediatr. 2025 Jul 9;25(1):541. doi: 10.1186/s12887-025-05904-1. PMID- 40628909 OWN - NLM STAT- MEDLINE DCOM- 20250708 LR - 20250712 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Jul 8 TI - Interaction of genetic risk score (GRS) and Plant-Based diet on atherogenic factors and body fat distribution indices among women with overweight and obesity: a cross-sectional study. PG - 24405 LID - 10.1038/s41598-025-09726-0 [doi] LID - 24405 AB - The association between plant-based diets, obesity, cardiovascular disease (CVD), and genetic predisposition is still not fully understood. This study explored how plant-based diets interact with genetic susceptibility to atherosclerosis and body fat in 377 Iranian women aged 18 to 48 who were overweight or obese. Using a validated 147-item food frequency questionnaire (FFQ), we established three plant-based diet indices: the Plant-Based Diet Index (PDI), the Healthy Plant-Based Diet Index (hPDI), and the Unhealthy Plant-Based Diet Index (uPDI). We calculated a Genetic Risk Score (GRS) based on three body mass index (BMI)-related single nucleotide polymorphisms (SNPs) and analyzed its interaction with the PDI. Results showed that tertile 2 of the PDI had a significant negative interaction with moderate and high-risk alleles on key atherogenic factors, including the atherogenic index of plasma (AIP), triglyceride glucose (TyG), lipid accumulation product (LAP), and visceral adiposity index (VAI) (P < 0.05). A borderline negative interaction between tertile 2 of the hPDI and moderate risk alleles regarding the Body Shape Index (ABSI) was also observed (P = 0.05). Conversely, tertile 2 of the uPDI had a significant positive interaction with moderate risk alleles related to both the Castelli Risk Index I (CRI.I) and II (CRI.II) (P = 0.03). This study suggests that interactions between genetic susceptibility and plant-based diet indices are linked to atherogenic factors and body composition. CI - (c) 2025. The Author(s). FAU - Hajmir, Mahya Mehri AU - Hajmir MM AD - Department of Exercise and Nutrition Sciences, The George Washington University, Washington, D.C, USA. FAU - Mirzababaei, Atieh AU - Mirzababaei A AD - Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. ati_babaee@yahoo.com. AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. ati_babaee@yahoo.com. AD - Nutrition & Dietetics, Department of Community Nutrition, School of Nutritional Sciences and Dietetics, in Tehran University of Medical Science (TUMS), Tehran University of Medical Sciences (TUMS), P.O. Box:14155-6117, Tehran, Iran. ati_babaee@yahoo.com. FAU - Abaj, Faezeh AU - Abaj F AD - Department of Nutrition, Dietetics and Food, School of Clinical Sciences at Monash Health, Monash University, Clayton, Australia. FAU - Aali, Yasaman AU - Aali Y AD - Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Samadi, Mahsa AU - Samadi M AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. FAU - Mirzaei, Khadijeh AU - Mirzaei K AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. mirzaei_kh@sina.tums.ac.ir. AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Science (TUMS), Tehran University of Medical Sciences (TUMS), P.O. Box:14155-6117, Tehran, Iran. mirzaei_kh@sina.tums.ac.ir. LA - eng GR - NO: IR. TUMS.VCR.REC.1398.142/Tehran University of Medical Sciences and Health Services/ GR - NO: IR. TUMS.VCR.REC.1398.142/Tehran University of Medical Sciences and Health Services/ GR - NO: IR. TUMS.VCR.REC.1398.142/Tehran University of Medical Sciences and Health Services/ GR - NO: IR. TUMS.VCR.REC.1398.142/Tehran University of Medical Sciences and Health Services/ GR - NO: IR. TUMS.VCR.REC.1398.142/Tehran University of Medical Sciences and Health Services/ GR - NO: IR. TUMS.VCR.REC.1398.142/Tehran University of Medical Sciences and Health Services/ PT - Journal Article DEP - 20250708 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Adult MH - *Obesity/genetics MH - Middle Aged MH - Cross-Sectional Studies MH - *Overweight/genetics MH - Polymorphism, Single Nucleotide MH - Genetic Predisposition to Disease MH - *Atherosclerosis/genetics MH - *Diet, Vegetarian/adverse effects MH - *Body Fat Distribution MH - Adolescent MH - Body Mass Index MH - Young Adult MH - Iran/epidemiology MH - Risk Factors MH - Genetic Risk Score MH - Diet, Plant-Based PMC - PMC12238419 OTO - NOTNLM OT - A body shape index OT - Atherogenic index of plasma OT - Body adiposity indices OT - Body roundness index OT - Lipid accumulation product OT - Plant dietary index COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: The study protocol was approved by the ethics committee of Tehran University of Medical Sciences (NO: IR. TUMS.VCR.REC.1398.142) and is acknowledged by the authors. A signed written informed consent was collected from all participants. Consent for publication: All authors performed editing and approved the final version of this paper for submission, participated in the finalization of the manuscript, and approved the final draft. EDAT- 2025/07/09 00:27 MHDA- 2025/07/09 00:28 PMCR- 2025/07/08 CRDT- 2025/07/08 23:29 PHST- 2024/09/07 00:00 [received] PHST- 2025/06/30 00:00 [accepted] PHST- 2025/07/09 00:28 [medline] PHST- 2025/07/09 00:27 [pubmed] PHST- 2025/07/08 23:29 [entrez] PHST- 2025/07/08 00:00 [pmc-release] AID - 10.1038/s41598-025-09726-0 [pii] AID - 9726 [pii] AID - 10.1038/s41598-025-09726-0 [doi] PST - epublish SO - Sci Rep. 2025 Jul 8;15(1):24405. doi: 10.1038/s41598-025-09726-0. PMID- 40626161 OWN - NLM STAT- MEDLINE DCOM- 20250708 LR - 20250709 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Constructing and evaluating the physical literacy index for college students in China: a new insight and perspective. PG - 1612356 LID - 10.3389/fpubh.2025.1612356 [doi] LID - 1612356 AB - BACKGROUND: College students today face significant challenges related to physical literacy, including declining fitness levels and low health awareness. Constructing a scientifically robust index to assess physical literacy in this demographic is essential. METHODS: We distributed 800 questionnaires via simple random sampling across eight universities, ultimately obtaining 706 valid responses from first- and second-year undergraduate students in Shanghai. Various components of physical literacy-including exercise motivation, attitude, commitment, confidence, body appreciation, willpower, physical activity, and fitness-were measured using established tools. Data analysis was conducted using SPSS 26.0, covering descriptive statistics, reliability and validity assessments, correlation analysis, and difference analysis. RESULTS: The Physical Literacy Index (PLI) for Chinese college students was developed through principal component analysis. The weights for the components were as follows: motivation for sports (0.171), attitude toward sports (0.147), physical fitness (0.163), commitment to sports (0.130), physical activity level (0.105), appreciation of the body (0.122), confidence in sports (0.091), and willpower in sports (0.070). The PLI showed a significant negative correlation with screen time (correlation coefficient of -0.257) and strong positive correlations with other variables, with the lowest correlation coefficient at 0.594, indicating effective calibration. The overall physical literacy level among Chinese college students is concerningly low, with no significant differences found across genders, ages, or regions of origin (p < 0.05). Despite a relatively high pass rate for physical fitness tests (64.16%), only 1.42% achieved excellent grades, and just 21.67% scored good. CONCLUSION: The physical literacy index of Chinese college students constructed in this study is scientific and valid, but the current situation regarding college students' physical literacy is worrying. In the future, physical education and health promotion should be emphasized and targeted measures should be taken to improve the physical literacy of college students. CI - Copyright (c) 2025 Wang, Piao, Ji, Liang, Chen, Yang, Cai and Wang. FAU - Wang, Hongbiao AU - Wang H AD - Department of Physical Education, Shanghai University of Medicine & Health Science, Shanghai, China. FAU - Piao, Zhongsu AU - Piao Z AD - Physical Education College, Jilin University, Changchun, China. FAU - Ji, Zhiguang AU - Ji Z AD - Department of Physical Education, Shanghai University of Medicine & Health Science, Shanghai, China. FAU - Liang, Leichao AU - Liang L AD - College of Rehabilitation, Shanghai University of Medicine & Health Science, Shanghai, China. FAU - Chen, Qianhong AU - Chen Q AD - College of Rehabilitation, Shanghai University of Medicine & Health Science, Shanghai, China. FAU - Yang, Ruoyu AU - Yang R AD - College of Rehabilitation, Shanghai University of Medicine & Health Science, Shanghai, China. FAU - Cai, Ming AU - Cai M AD - College of Rehabilitation, Shanghai University of Medicine & Health Science, Shanghai, China. FAU - Wang, Liyan AU - Wang L AD - College of Rehabilitation, Shanghai University of Medicine & Health Science, Shanghai, China. LA - eng PT - Journal Article DEP - 20250623 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - China MH - *Students/statistics & numerical data/psychology MH - Female MH - Male MH - Universities MH - Surveys and Questionnaires MH - Young Adult MH - *Health Literacy/statistics & numerical data MH - Exercise/psychology MH - Physical Fitness MH - Adult MH - Adolescent MH - Motivation MH - Reproducibility of Results PMC - PMC12229837 OTO - NOTNLM OT - assessment OT - college students OT - health promotion OT - physical literacy index OT - principal component analysis COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/07/08 06:26 MHDA- 2025/07/08 12:53 PMCR- 2025/06/23 CRDT- 2025/07/08 05:48 PHST- 2025/04/15 00:00 [received] PHST- 2025/06/06 00:00 [accepted] PHST- 2025/07/08 12:53 [medline] PHST- 2025/07/08 06:26 [pubmed] PHST- 2025/07/08 05:48 [entrez] PHST- 2025/06/23 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1612356 [doi] PST - epublish SO - Front Public Health. 2025 Jun 23;13:1612356. doi: 10.3389/fpubh.2025.1612356. eCollection 2025. PMID- 40624507 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 24 IP - 1 DP - 2025 Jul 7 TI - Associations between dietary macronutrient quality and odds of hyperlipidemia: findings from the NEC-Biobank cohort. PG - 107 LID - 10.1186/s12937-025-01174-w [doi] LID - 107 AB - BACKGROUND: Associations between the overall quality of dietary macronutrients and the odds of hyperlipidemia remain unknown. This study aimed to first investigate the aforementioned associations, applying a novel multidimensional macronutrient quality index (MQI). METHODS: A large cross-sectional study (2018-2020) was carried out among 14,544 participants aged 18-79 years from the NEC-Biobank cohort (Northeast region, China). Dietary information was collected from a validated 110-item food frequency questionnaire. MQI was calculated based on fat quality index (FQI), protein quality index (PQI), and carbohydrate quality index (CQI). Binary logistic regression models were used to assess the odds ratio (OR) with 95% confidence intervals (CI). RESULTS: Higher MQI was associated with significantly reduced odds of hyperlipidemia (ORtertile 3 vs. tertile 1 = 0.82, 95% CI: 0.75-0.90; P trend < 0.001). For MQI's sub-indices, higher FQI (ORtertile 3 vs. tertile 1 = 0.84, 95% CI: 0.77-0.91; P trend < 0.001) as well as higher PQI (ORtertile 3 vs. tertile 1 = 0.86, 95% CI: 0.79-0.94; P trend < 0.001) were associated with lower odds of hyperlipidemia. CONCLUSIONS: Our findings suggested that intake of high-quality macronutrients was associated with reduced odds of hyperlipidemia. These findings contribute novel knowledge to the field of nutrition and metabolic diseases, and lay the foundation for future studies. CLINICAL TRIAL NUMBER: Not applicable. FAU - Li, Xiao-Ying AU - Li XY AD - Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China. AD - Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Huang, Dong-Hui AU - Huang DH AD - Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China. AD - Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Xu, Xin AU - Xu X AD - Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China. AD - Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Zhang, Xi-Meng AU - Zhang XM AD - Department of Dermatology, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Lv, Jia-Le AU - Lv JL AD - Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China. AD - Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Nan, Yu-Xin AU - Nan YX AD - Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China. AD - Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Cao, Fan AU - Cao F AD - Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China. AD - Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Wu, Qi-Jun AU - Wu QJ AD - Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China. wuqj@sj-hospital.org. AD - Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China. wuqj@sj-hospital.org. AD - NHC Key Laboratory of Advanced Reproductive Medicine and Fertility, China Medical University, National Health Commission, Shenyang, China. wuqj@sj-hospital.org. FAU - Zhao, Yu-Hong AU - Zhao YH AUID- ORCID: 0000-0002-6806-521X AD - Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China. zhaoyuhong@sj-hospital.org. AD - Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China. zhaoyuhong@sj-hospital.org. AD - Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China. zhaoyuhong@sj-hospital.org. LA - eng GR - 2022YFC2704205/National Key Research and Development Program of China/ GR - 2021JH1/10400050/JieBangGuaShuai Project of Liaoning Province/ PT - Journal Article DEP - 20250707 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 RN - 0 (Dietary Fats) RN - 0 (Dietary Proteins) RN - 0 (Dietary Carbohydrates) SB - IM MH - Humans MH - *Hyperlipidemias/epidemiology MH - Cross-Sectional Studies MH - *Nutrients/analysis MH - China/epidemiology MH - Female MH - Middle Aged MH - Adult MH - Male MH - *Diet/statistics & numerical data/methods MH - Aged MH - Dietary Fats MH - Young Adult MH - Odds Ratio MH - Adolescent MH - Cohort Studies MH - Dietary Proteins MH - Dietary Carbohydrates PMC - PMC12235856 OTO - NOTNLM OT - Carbohydrate quality OT - Fat quality OT - Hyperlipidemia OT - Macronutrient quality OT - Protein quality COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki and approved by the ethical committee of Shengjing Hospital of China Medical University (2017PS190K). All participants submitted the written informed consent. Competing interests: The authors declare no competing interests. EDAT- 2025/07/08 00:27 MHDA- 2026/06/27 00:57 PMCR- 2025/07/07 CRDT- 2025/07/07 23:46 PHST- 2025/03/25 00:00 [received] PHST- 2025/06/24 00:00 [accepted] PHST- 2026/06/27 00:57 [medline] PHST- 2025/07/08 00:27 [pubmed] PHST- 2025/07/07 23:46 [entrez] PHST- 2025/07/07 00:00 [pmc-release] AID - 10.1186/s12937-025-01174-w [pii] AID - 1174 [pii] AID - 10.1186/s12937-025-01174-w [doi] PST - epublish SO - Nutr J. 2025 Jul 7;24(1):107. doi: 10.1186/s12937-025-01174-w. PMID- 40623791 OWN - NLM STAT- MEDLINE DCOM- 20250707 LR - 20260720 IS - 2059-7908 (Print) IS - 2059-7908 (Electronic) IS - 2059-7908 (Linking) VI - 10 IP - 7 DP - 2025 Jul 7 TI - Development and validation of a novel clinical risk score to predict hypoxaemia in children with pneumonia using the WHO PREPARE dataset. LID - 10.1136/bmjgh-2024-017256 [doi] LID - e017256 AB - BACKGROUND: Hypoxaemia predicts mortality at all levels of care, and appropriate management can reduce preventable deaths. However, pulse oximetry and oxygen therapy remain inaccessible in many primary care health facilities. We aimed to develop and validate a simple risk score comprising commonly evaluated clinical features to predict hypoxaemia in 2-59-month-old children with pneumonia. METHODS: Data from seven studies conducted in five countries from the Pneumonia Research Partnership to Assess WHO Recommendations (PREPARE) dataset were included. Readily available clinical features and demographic variables were used to develop a multivariable logistic regression model to predict hypoxemia (oxygen saturation <90%) at presentation to care. The adjusted log coefficients were transformed to derive the PREPARE hypoxemia risk score and its diagnostic value was assessed in a held-out, temporal validation dataset. The model and risk score were analysed by evaluating the area under the receiver operating characteristic curve (AUC), sensitivity and specificity. RESULTS: We included 14 509 children in the analysis; 9.8% (n=2515) were hypoxemic at presentation. The multivariable regression model to predict hypoxemia included age, sex, respiratory distress (nasal flaring, grunting and/or head nodding), lower chest indrawing, respiratory rate, body temperature and weight-for-age z-score. The model showed fair discrimination (AUC 0.70, 95% CI 0.67 to 0.73) and calibration in the validation dataset. The simplified PREPARE hypoxaemia risk score includes five variables: age, respiratory distress, lower chest indrawing, respiratory rate and weight-for-age z-score. CONCLUSION: The PREPARE hypoxemia risk score, comprising five easily available characteristics, has the potential to be used to identify hypoxemia in children with pneumonia with a fair degree of certainty for use in health facilities without pulse oximetry. Its implementation would require careful consideration to limit the burden of inappropriate referrals on patients and the health system. Further external validation in community settings in low- and middle-income countries is required. CI - (c) World Health Organization 2025. Licensee BMJ. FAU - Tan, Rainer AU - Tan R AUID- ORCID: 0000-0002-9273-9632 AD - Digital and Global Health Unit, Center for Primary Care and Public Health, Lausanne, Switzerland. AD - Swiss Tropical and Public Health Institute, Basel, Switzerland. FAU - Chandna, Arjun AU - Chandna A AD - University of Oxford, Oxford, UK. AD - Angkor Hospital for Children, Siem Reap, Siem Reap, Cambodia. FAU - Colbourn, Tim AU - Colbourn T AUID- ORCID: 0000-0002-6917-6552 AD - UCL Institute for Global Health, London, UK. FAU - Hooli, Shubhada AU - Hooli S AD - Baylor College of Medicine, Houston, Texas, USA. FAU - King, Carina AU - King C AUID- ORCID: 0000-0002-6885-6716 AD - Karolinska Institute, Stockholm, Sweden. FAU - Lufesi, Norman AU - Lufesi N AD - Acute Respiratory Illness Unit, Government of Malawi Ministry of Health, Lilongwe, Malawi. FAU - McCollum, Eric D AU - McCollum ED AUID- ORCID: 0000-0002-1872-5566 AD - Johns Hopkins School of Medicine, Baltimore, Maryland, USA. FAU - Mwansambo, Charles AU - Mwansambo C AD - Ministry of Health, Lilongwe, Malawi. FAU - Mathew, Joseph L AU - Mathew JL AD - Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India. FAU - Cutland, Clare L AU - Cutland CL AD - Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand Johannesburg, Johannesburg, South Africa. FAU - Madhi, Shabir A AU - Madhi SA AD - South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, University of the Witwatersrand Faculty of Health Sciences, Parktown, South Africa. FAU - Nunes, Marta AU - Nunes M AD - University of the Witwatersrand, Johannesburg-Braamfontein, South Africa. FAU - Basnet, Sudha AU - Basnet S AD - Center for Intervention Science in Maternal and Child Health, University of Bergen, Bergen, Norway. FAU - Strand, Tor A AU - Strand TA AD - Centre for International Health, University of Bergen, Bergen, Norway. FAU - O'Grady, Kerry-Ann F AU - O'Grady KF AD - Institute of Health & Biomedical Innovation @ Centre for Children's Health Research, Queensland University of Technology, South Brisbane, Queensland, Australia. FAU - Gessner, Brad AU - Gessner B AD - Pfizer Vaccines, Collegeville, Pennsylvania, USA. FAU - Addo-Yobo, Emmanuel AU - Addo-Yobo E AD - Komfo Anokye Teaching Hospital, Kumasi, Ghana. FAU - Chisaka, Noel AU - Chisaka N AD - World Bank, Washington, District of Columbia, USA. FAU - Hibberd, Patricia AU - Hibberd P AD - Boston University School of Public Health, Boston, Massachusetts, USA. AD - Boston University School of Medicine, Boston, Massachusetts, USA. FAU - Jeena, Prakash M AU - Jeena PM AD - Department of Paediatrics & Child Health, University of KwaZulu-Natal Nelson R Mandela School of Medicine, Durban, South Africa. FAU - Lozano, Juan M AU - Lozano JM AD - Florida International University, Miami, Florida, USA. FAU - MaLeod, William B AU - MaLeod WB AD - Department of Global Health, Boston University School of Public Health, Boston, Massachusetts, USA. FAU - Patel, Archana AU - Patel A AD - Research, Lata Medical Research Foundation, Nagpur, Maharashtra, India. FAU - Thea, Donald M AU - Thea DM AD - Department of Global Health, Boston University School of Public Health, Boston, Massachusetts, USA. FAU - Nguyen, Ngoc Tuong Vy AU - Nguyen NTV AD - Children Hospital No 1, Ho Chi Minh City, Viet Nam. FAU - Lucero, Marilla AU - Lucero M AD - Research Institute for Tropical Medicine, Manila, Philippines. FAU - Akram Uz Zaman, Syed Mohammad AU - Akram Uz Zaman SM AD - Education, Liverpool School of Tropical Medicine, Liverpool, UK. AD - Liverpool School of Tropical Medicine, Liverpool, UK. FAU - Bhatnagar, Shinjini AU - Bhatnagar S AD - Translational Health Science and Technology Institute, Faridabad, Haryana, India. FAU - Wadhwa, Nitya AU - Wadhwa N AD - Translational Health Science and Technology Institute, Faridabad, Haryana, India. FAU - Lodha, Rakesh AU - Lodha R AD - All India Institute of Medical Sciences, New Delhi, Delhi, India. FAU - Aneja, Satinder AU - Aneja S AD - Sharda University School of Medical Sciences and Research, Greater Noida, Uttar Pradesh, India. FAU - Santosham, Mathuram AU - Santosham M AD - International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Awasthi, Shally AU - Awasthi S AD - Department of Pediatrics, King George's Medical University, Lucknow, Uttar Pradesh, India. AD - King George's Medical University, Lucknow, Uttar Pradesh, India. FAU - Bavdekar, Ashish AU - Bavdekar A AD - Department of Pediatrics, KEM Hospital Pune, Pune, Maharashtra, India. FAU - Chou, Monidarin AU - Chou M AD - Rodolph Merieux Laboratory, University of Health Sciences Faculty of Medicine, Phnom Penh, Cambodia. FAU - Nymadawa, Pagbajabyn AU - Nymadawa P AD - Mongolian Academy of Sciences, Ulaanbaatar, Mongolia. FAU - Pape, Jean William AU - Pape JW AD - GHESKIO, Port-au-Prince, Ouest, Haiti. AD - Joan and Sanford I Weill Medical College of Cornell University, New York, New York, USA. FAU - Paranhos-Baccala, Glaucia AU - Paranhos-Baccala G AD - Fondation Merieux, Lyon, France. FAU - Picot, Valentina S AU - Picot VS AD - Fondation Merieux, Lyon, France. FAU - Rakoto-Andrianarivelo, Mala AU - Rakoto-Andrianarivelo M AD - Centre d'Infectiologie Charles Merieux, Antanarivo, Madagascar. FAU - Rouzier, Vanessa AU - Rouzier V AD - GHESKIO, Port-au-Prince, Ouest, Haiti. FAU - Russomando, Graciela AU - Russomando G AD - Universidad Nacional de Asuncion, San Lorenzo, Paraguay. FAU - Sylla, Mariam AU - Sylla M AUID- ORCID: 0000-0002-8853-4132 AD - Gabriel Toure University Hospital Center, Bamako, Mali. FAU - Vanhems, Philippe AU - Vanhems P AD - Unite d'Hygiene, Epidemiologie, Infectiovigilance et Prevention, Hospices Civils de Lyon, Lyon, France. FAU - Wang, Jianwei AU - Wang J AD - MOH Key Laboratory of Systems Biology of Pathogens and Dr Christophe Merieux Laboratory, Chinese Academy of Medical Sciences & Peking Union, Beijing, China. FAU - Libster, Romina AU - Libster R AD - Fundacion Infant, Buenos Aires, Argentina. FAU - Clara, Alexey W AU - Clara AW AUID- ORCID: 0000-0003-3779-3449 AD - DVD, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. FAU - Beynon, Fenella AU - Beynon F AUID- ORCID: 0000-0002-4758-8847 AD - Swiss Centre for International Health, Swiss Tropical and Public Health Institute, Allschwil, Switzerland. AD - University of Basel, Basel, Switzerland. FAU - Levine, Gillian AU - Levine G AD - Medicine, Swiss Tropical and Public Health Institute, Allschwil, Switzerland. FAU - Rees, Chris A AU - Rees CA AD - Department of Pediatrics, Emory University School of Medicine Atlanta, Atlanta, Georgia, USA. AD - Children's Healthcare of Atlanta, Atlanta, Georgia, USA. FAU - Neuman, Mark I AU - Neuman MI AD - Division of Emergency Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. FAU - Qazi, Shamim AU - Qazi S AD - Independent Consultant Paediatrician, Geneva, Switzerland. FAU - Nisar, Yasir Bin AU - Nisar YB AUID- ORCID: 0000-0002-9720-5699 AD - Department of Maternal, Newborn, Child, and Adolescent Health and Ageing, World Health Organization, Geneva, Switzerland nisary@who.int. CN - World Health Organization PREPARE study group LA - eng GR - 001/WHO_/World Health Organization/International GR - INV-007927/GATES/Gates Foundation/United States GR - K23 HL169901/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Validation Study DEP - 20250707 PL - England TA - BMJ Glob Health JT - BMJ global health JID - 101685275 SB - IM MH - Humans MH - *Hypoxia/diagnosis/etiology MH - *Pneumonia/complications MH - Male MH - Female MH - Infant MH - Child, Preschool MH - Risk Assessment/methods MH - World Health Organization MH - Risk Factors MH - Oximetry PMC - PMC12232467 OTO - NOTNLM OT - Child health OT - Global Health OT - Pneumonia COIS- Competing interests: None declared. EDAT- 2025/07/08 00:27 MHDA- 2025/07/08 00:28 PMCR- 2025/07/07 CRDT- 2025/07/07 20:53 PHST- 2024/08/23 00:00 [received] PHST- 2025/04/13 00:00 [accepted] PHST- 2025/07/08 00:28 [medline] PHST- 2025/07/08 00:27 [pubmed] PHST- 2025/07/07 20:53 [entrez] PHST- 2025/07/07 00:00 [pmc-release] AID - bmjgh-2024-017256 [pii] AID - 10.1136/bmjgh-2024-017256 [doi] PST - epublish SO - BMJ Glob Health. 2025 Jul 7;10(7):e017256. doi: 10.1136/bmjgh-2024-017256. PMID- 40623649 OWN - NLM STAT- Publisher LR - 20260126 IS - 2213-2961 (Electronic) IS - 2095-2546 (Print) IS - 2213-2961 (Linking) VI - 15 DP - 2025 Jul 5 TI - Content validation of the Global Adolescent and Child Physical Activity Questionnaire (GAC-PAQ) in low-, middle-, and high-income countries across 6 continents. PG - 101074 LID - S2095-2546(25)00053-5 [pii] LID - 10.1016/j.jshs.2025.101074 [doi] LID - 101074 AB - BACKGROUND: Investigators from low-, middle-, and high-income countries representing 6 continents contributed to the development of the Global Adolescent and Child Physical Activity Questionnaire (GAC-PAQ). The GAC-PAQ is designed to assess physical activity (PA) across all key domains (i.e., school, chores, work/volunteering, transport, free time, outdoor time). It aimed to address multiple gaps in global PA surveillance (e.g., omission of important PA domains, insufficient cultural adaptation, underrepresentation of rural areas in questionnaire validation studies).The purpose of this study was to assess the content validity of the GAC-PAQ among PA experts, 8- to 17-year-olds, and one of their parents/guardians, and to discuss changes made to the questionnaire based on participants' feedback. METHODS: Sixty-two experts in PA measurement and/or surveillance from 24 countries completed an online survey that included both closed- and open-ended questions about the content validity of the GAC-PAQ. The proportion of experts who agreed or strongly agreed with the items was calculated. Child-parent/guardian dyads from 15 countries (n = 250; 10-40 per country) participated in a structured cognitive interview to assess the clarity of the questions and response options, and they were encouraged to provide suggestions to improve clarity and facilitate completion of the questionnaire. Participating countries are: Aotearoa New Zealand, Brazil, Canada, China, Colombia, Czech Republic, India, Malawi, Mexico, Nepal, Nigeria, Spain, Sweden, Thailand, and the United Arab Emirates. Interviews were conducted in 13 different languages and structured by PA domain. Generic images were included to help participants in answering questions about PA intensity. RESULTS: Expert agreement with the items for each domain exceeded 75%, and their qualitative feedback was used to revise the questionnaire before cognitive interviews. In general, participants found the questionnaire to be comprehensive. Adolescents (12-17 years) found it easier than children (8-11 years) to answer the questions. Several children struggled to answer questions about the duration and intensity of activities and/or concepts related to travel modes, active trips, and organized activities. Many parents/guardians were unsure about the frequency, duration, and intensity of their children's or adolescents' PA at school and/or recommended using more culturally relevant and appropriate images. Some participants misunderstood the concept of activities that "make you stronger" (intended to assess resistance activities) and/or struggled to differentiate between work, volunteering, and chores. CONCLUSION: Participants' feedback was used to develop a revised, simplified, and culturally adapted GAC-PAQ, which will be pilot-tested in all 15 countries in an App that will include country-specific images and narration in local languages. Further research is needed to assess the reliability and validity of the revised GAC-PAQ. CI - Copyright (c) 2026. Production and hosting by Elsevier B.V. FAU - Larouche, Richard AU - Larouche R AD - Faculty of Health Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada. Electronic address: richard.larouche@uleth.ca. FAU - Neves de Oliveira, Saulo AU - Neves de Oliveira S AD - Faculty of Health Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada; School of Education, Ambrose University, Calgary, AB T3H 0L5, Canada. FAU - Rostami Haji Abadi, Mahdi AU - Rostami Haji Abadi M AD - Faculty of Health Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada. FAU - Benavides-Castro, Judy K AU - Benavides-Castro JK AD - School of Medicine, Universidad de los Andes, Bogota 111711, Colombia. FAU - Sarmiento, Olga L AU - Sarmiento OL AD - School of Medicine, Universidad de los Andes, Bogota 111711, Colombia. FAU - Angulo Garay, Garazi AU - Angulo Garay G AD - Department of Sports and Computer Science, Universidad Pablo de Olavide, Sevilla 41013, Spain. FAU - Argumedo, Gabriela AU - Argumedo G AD - Department of Physical Activity and Healthy Lifestyles, National Institute of Public Health, Cuernavaca 62100, Mexico. FAU - Ashaolu, Joseph O AU - Ashaolu JO AD - Department of Physiotherapy, Redeemer's University, Akoda 232101, Nigeria. FAU - Baghestani, Ameneh AU - Baghestani A AD - College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai PO Box 505055, United Arab Emirates. FAU - Bhawra, Jasmin AU - Bhawra J AD - School of Occupational and Public Health, Toronto Metropolitan University, Toronto, ON M5B 2K3, Canada. FAU - Brazo-Sayavera, Javier AU - Brazo-Sayavera J AD - Department of Sports and Computer Science, Universidad Pablo de Olavide, Sevilla 41013, Spain. FAU - Choonak, Nutnaree AU - Choonak N AD - Institute for Population and Social Research, Mahidol University, Nakhon Pathom 73170, Thailand. FAU - Nystrom, Christine Delisle AU - Nystrom CD AD - Department of Medicine, Karolinska Institutet, NEO, Group MLO, Huddinge 141 83, Sweden. FAU - Evance, Seth AU - Evance S AD - Centre for Social Research, University of Malawi, Zomba 305200, Malawi. FAU - Hamrik, Zdenek AU - Hamrik Z AD - Faculty of Physical Culture, Palacky University Olomouc, Olomouc 779 00, Czech Republic. FAU - Jauregui, Alejandra AU - Jauregui A AD - Department of Physical Activity and Healthy Lifestyles, National Institute of Public Health, Cuernavaca 62100, Mexico. FAU - Kaewpikul, Piyakrita AU - Kaewpikul P AD - Institute for Population and Social Research, Mahidol University, Nakhon Pathom 73170, Thailand. FAU - Katewongsa, Piyawat AU - Katewongsa P AD - Institute for Population and Social Research, Mahidol University, Nakhon Pathom 73170, Thailand. FAU - Khadilkar, Anuradha AU - Khadilkar A AD - Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune 411001, India; Interdisciplinary School of Health Sciences, Savitribai Phule Pune University, Pune 411007, India. FAU - Kira, Geoff AU - Kira G AD - Te Hau Kori, Faculty of Health, Victoria University of Wellington, Wellington 6140, Aotearoa New Zealand. FAU - Kuntembwe, McPherry AU - Kuntembwe M AD - Centre for Social Research, University of Malawi, Zomba 305200, Malawi. FAU - Liu, Yang AU - Liu Y AD - School of Physical Education, Shanghai University of Sport, Shanghai 200438, China. FAU - Lof, Marie AU - Lof M AD - Department of Medicine, Karolinska Institutet, NEO, Group MLO, Huddinge 141 83, Sweden. FAU - Loney, Tom AU - Loney T AD - College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai PO Box 505055, United Arab Emirates. FAU - Lundgren, Maria AU - Lundgren M AD - Department of Medicine, Karolinska Institutet, NEO, Group MLO, Huddinge 141 83, Sweden. FAU - Mandlik, Rubina AU - Mandlik R AD - Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune 411001, India; Interdisciplinary School of Health Sciences, Savitribai Phule Pune University, Pune 411007, India. FAU - Matapo-Kolisko, Martine AU - Matapo-Kolisko M AD - Te Hau Kori, Faculty of Health, Victoria University of Wellington, Wellington 6140, Aotearoa New Zealand. FAU - More, Chidvilas AU - More C AD - Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune 411001, India. FAU - Mwase-Vuma, Tawonga W AU - Mwase-Vuma TW AD - Centre for Social Research, University of Malawi, Zomba 305200, Malawi; Department of Psychological Sciences and Health, University of Strathclyde, Glasgow G1 1QE, UK. FAU - Nilwatta, Nattaporn AU - Nilwatta N AD - Institute for Population and Social Research, Mahidol University, Nakhon Pathom 73170, Thailand. FAU - Oyeyemi, Adewale L AU - Oyeyemi AL AD - Department of Physiotherapy, Redeemer's University, Akoda 232101, Nigeria; College of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA. FAU - Paudel, Susan AU - Paudel S AD - Nepal Development Society, Kathmandu, Nepal; Institute for Physical Activity and Nutrition, Deakin University, Burwood, VIC 3125, Australia. FAU - Pomkai, Nanthawan AU - Pomkai N AD - Institute for Population and Social Research, Mahidol University, Nakhon Pathom 73170, Thailand. FAU - Richards, Justin AU - Richards J AD - Te Hau Kori, Faculty of Health, Victoria University of Wellington, Wellington 6140, Aotearoa New Zealand. FAU - Silva, Diego Augusto Santos AU - Silva DAS AD - Department of Physical Education, Federal University of Santa Catarina, Florianopolis 88040-900, Brazil. FAU - Smith, Melody AU - Smith M AD - Waipapa Taumata Rau/University of Auckland, Auckland 1142, New Zealand. FAU - Subedi, Narayan AU - Subedi N AD - Nepal Development Society, Kathmandu, Nepal; Institute for Physical Activity and Nutrition, Deakin University, Burwood, VIC 3125, Australia. FAU - Widyastari, Dyah Anantalia AU - Widyastari DA AD - Institute for Population and Social Research, Mahidol University, Nakhon Pathom 73170, Thailand. FAU - Wilson, Oliver W A AU - Wilson OWA AD - Te Hau Kori, Faculty of Health, Victoria University of Wellington, Wellington 6140, Aotearoa New Zealand. FAU - Aubert, Salome AU - Aubert S AD - Active Healthy Kids Global Alliance, Ottawa, ON K1H 8L1, Canada. FAU - Carson, Valerie AU - Carson V AD - Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB T6G 2H9, Canada. FAU - Colley, Rachel C AU - Colley RC AD - Health Analysis Division, Statistics Canada, Ottawa, ON K1A 0T6, Canada. FAU - Esliger, Dale W AU - Esliger DW AD - School of Sport, Exercise, and Health Sciences, Loughborough University, Loughborough, LE11 3TU, UK. FAU - Kuzik, Nicholas AU - Kuzik N AD - Healthy Active Living and Obesity Research Group, CHEO Research Institute, Ottawa, ON K1H 8L1, Canada. FAU - Manyanga, Taru AU - Manyanga T AD - Division of Medical Sciences, University of Northern British Columbia, Prince George, BC V2N 4Z9, Canada. FAU - Reilly, John J AU - Reilly JJ AD - Department of Psychological Sciences and Health, University of Strathclyde, Glasgow G1 1QE, UK. FAU - Vanderloo, Leigh M AU - Vanderloo LM AD - Healthy Active Living and Obesity Research Group, CHEO Research Institute, Ottawa, ON K1H 8L1, Canada; ParticipACTION, Toronto, Ontario M5R 1P6, Canada; School of Occupational Therapy, University of Western Ontario, London, Ontario N6A 3K7, Canada. FAU - Tremblay, Mark S AU - Tremblay MS AD - Active Healthy Kids Global Alliance, Ottawa, ON K1H 8L1, Canada; Healthy Active Living and Obesity Research Group, CHEO Research Institute, Ottawa, ON K1H 8L1, Canada; Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 5B2, Canada. LA - eng PT - Journal Article DEP - 20250705 PL - China TA - J Sport Health Sci JT - Journal of sport and health science JID - 101606001 SB - IM PMC - PMC12828600 OTO - NOTNLM OT - Content validity OT - Cultural adaptation OT - Global health OT - Measurement OT - Surveillance EDAT- 2025/07/08 00:27 MHDA- 2025/07/08 00:27 PMCR- 2025/07/05 CRDT- 2025/07/07 19:33 PHST- 2024/12/19 00:00 [received] PHST- 2025/03/01 00:00 [revised] PHST- 2025/03/11 00:00 [accepted] PHST- 2025/07/08 00:27 [pubmed] PHST- 2025/07/08 00:27 [medline] PHST- 2025/07/07 19:33 [entrez] PHST- 2025/07/05 00:00 [pmc-release] AID - S2095-2546(25)00053-5 [pii] AID - 101074 [pii] AID - 10.1016/j.jshs.2025.101074 [doi] PST - aheadofprint SO - J Sport Health Sci. 2025 Jul 5;15:101074. doi: 10.1016/j.jshs.2025.101074. PMID- 40623370 OWN - NLM STAT- MEDLINE DCOM- 20251016 LR - 20260206 IS - 1421-9832 (Electronic) IS - 1018-8665 (Print) IS - 1018-8665 (Linking) VI - 241 IP - Suppl. 1 DP - 2025 TI - Prevalence of Hidradenitis Suppurativa in Serbia: Validation of a Screening Questionnaire. PG - 117-122 LID - 10.1159/000539877 [doi] AB -

Introduction: Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by painful nodules and rupturing abscesses causing sinus tunnels and scarring, most commonly in the axilla, inguinal, perianal, and submammary areas. The global prevalence varies considerably, ranging from 0.00033% to 4.1%. To date, no epidemiological studies on HS have been conducted in Serbia. The aim of the study was to determine the prevalence of HS in Serbia. METHODS: This research is a monocentric study initiated by the Global Hidradenitis Suppurativa Atlas (GHISA), conducted at the Military Medical Academy in Belgrade, and is part of the GHISA project. The study included healthy companions of the patients who filled out a validated questionnaire in the local language in which they reported their gender, age, weight, height, cigarette consumption, and the presence of painful nodules on the skin of the body folds. All people who reported having the changes defined in the questionnaire and every tenth person who said there were no changes were examined by experienced dermatologists and final year dermatology residents. RESULTS: In the study, among 490 respondents, 4 were confirmed as HS, the point prevalence was 0.82%. HS was diagnosed equally in women and men. All patients had a BMI above normal, which is a known risk factor for HS. The affected regions in the HS group were the axilla and groin. The screening questionnaire had a sensitivity of 0.5 (2/4), a specificity of 0.93 (62/67), a positive predictive value of 0.29 (2/7), and a negative predictive value of 0.97 (62/64). CONCLUSION: The prevalence of HS in Belgrade, Serbia is 0.82%. The disease occurs equally frequently in both sexes. The HS screening questionnaire proves to be an appropriate instrument for population surveys.

. CI - (c) 2025 The Author(s). Published by S. Karger AG, Basel. FAU - Jocic, Ivana AU - Jocic I AD - Department of Dermatology, Faculty of Medicine, Military Medical Academy, Belgrade, Serbia, jocic.ivana93@gmail.com. FAU - Dujovic, Branko AU - Dujovic B AD - Department of Dermatology, Faculty of Medicine, Military Medical Academy, Belgrade, Serbia. FAU - Kandolf, Lidija AU - Kandolf L AD - Department of Dermatology, Faculty of Medicine, Military Medical Academy, Belgrade, Serbia. FAU - Bouazzi, Dorra AU - Bouazzi D AD - Department of Dermatology, Zealand University Hospital, Roskilde, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. AD - Section for Biostatistics and Evidence-Based Research, the Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark. FAU - Medianfar, Cecilia E AU - Medianfar CE AD - Department of Dermatology, Zealand University Hospital, Roskilde, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. FAU - Christensen, Robin AU - Christensen R AD - Section for Biostatistics and Evidence-Based Research, the Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark. AD - Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark. AD - Department of Clinical Research, Cochrane Denmark & Centre for Evidence-Based Medicine Odense (CEBMO), University of Southern Denmark, Odense, Denmark. FAU - Jemec, Gregor B E AU - Jemec GBE AD - Department of Dermatology, Zealand University Hospital, Roskilde, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. FAU - Mijuskovic, Zeljko AU - Mijuskovic Z AD - Department of Dermatology, Faculty of Medicine, Military Medical Academy, Belgrade, Serbia. LA - eng PT - Journal Article PT - Validation Study DEP - 20250707 PL - Switzerland TA - Dermatology JT - Dermatology (Basel, Switzerland) JID - 9203244 SB - IM MH - Humans MH - *Hidradenitis Suppurativa/epidemiology/diagnosis MH - Serbia/epidemiology MH - Female MH - Male MH - Prevalence MH - Adult MH - Surveys and Questionnaires MH - Middle Aged MH - Young Adult MH - Adolescent MH - Mass Screening/methods PMC - PMC12233986 OTO - NOTNLM OT - Epidemiology OT - Global Hidradenitis Suppurativa Atlas OT - Hidradenitis suppurativa OT - Prevalence OT - Serbia COIS- G.B.E.J. has received honoraria from AbbVie, ChemoCentryx, Coloplast, Incyte, InflaRx, Novartis, Pierre Fabre, and UCB, for participation on advisory boards; grants from AbbVie, AstraZeneca, InflaRx, Janssen-Cilag, Leo Pharma, Novartis, Regeneron, and Sanofi, for participation as an investigator; and speaker honoraria from AbbVie, Boehringer-Ingelheim, Galderma, and MSD. He has also received unrestricted departmental grants from AbbVie, Leo Pharma, and Novartis. D.B. declares that UCB Nordic has paid for EADV 2022 and EADV 2023 congress participation and received teaching honoraria from UCB Nordic. All other authors have no conflicts of interest to declare. EDAT- 2025/07/08 00:27 MHDA- 2025/10/16 18:36 PMCR- 2025/07/07 CRDT- 2025/07/07 18:22 PHST- 2024/02/11 00:00 [received] PHST- 2024/06/10 00:00 [accepted] PHST- 2025/10/16 18:36 [medline] PHST- 2025/07/08 00:27 [pubmed] PHST- 2025/07/07 18:22 [entrez] PHST- 2025/07/07 00:00 [pmc-release] AID - 000539877 [pii] AID - 539877 [pii] AID - 10.1159/000539877 [doi] PST - ppublish SO - Dermatology. 2025;241(Suppl. 1):117-122. doi: 10.1159/000539877. Epub 2025 Jul 7. PMID- 40623308 OWN - NLM STAT- MEDLINE DCOM- 20250825 LR - 20260703 IS - 1539-3704 (Electronic) IS - 0003-4819 (Linking) VI - 178 IP - 8 DP - 2025 Aug TI - Implications of the European Association for the Study of Obesity's New Framework Definition of Obesity: Prevalence and Association With All-Cause Mortality. PG - 1065-1072 LID - 10.7326/ANNALS-24-02547 [doi] AB - BACKGROUND: The European Association for the Study of Obesity (EASO) recently introduced a new framework to define obesity that incorporates anthropometric measures beyond body mass index (BMI) and clinical comorbidities. However, this framework has not been validated. OBJECTIVE: To describe the distribution of overweight and obesity and determine the prevalence of complications and association of obesity with all-cause mortality using BMI categories and the new EASO framework. DESIGN: Cross-sectional and longitudinal analysis. SETTING: NHANES (National Health and Nutrition Examination Survey) from 1999 to 2018 linked to mortality data. PARTICIPANTS: A representative sample of the adult population in the United States aged 18 to 79 years. MEASUREMENTS: Obesity defined using BMI categories was compared with the new EASO definition. RESULTS: The study population included 44 030 adults. On the basis of the new EASO definition, 18.8% of adults who were previously defined as overweight based on BMI alone were now considered persons with obesity (PWO). Similar mortality risk was found among the newly identified PWO and persons with normal weight (hazard ratio [HR], 0.98 [95% CI, 0.87 to 1.10]), whereas higher risk was seen among persons with BMI of 30 kg/m(2) or greater (HR, 1.19 [CI, 1.08 to 1.32]). However, when compared with persons with normal weight who did not have major morbidities, a higher risk was seen among the newly identified PWO (HR, 1.50 [CI, 1.20 to 1.88]), although this higher risk was no greater than the higher risk seen among persons with normal weight and comorbidities (HR, 1.74 [CI, 1.34 to 2.22]). Excess risk was seen among PWO compared with persons with overweight according to both the new EASO framework and the traditional BMI definition. The most prevalent complications among the newly identified PWO were hypertension (79.9%), arthritis (33.2%), diabetes (15.6%), and cardiovascular disease (10.5%). LIMITATION: Residual confounding; body weight assessed at a single time point. CONCLUSION: The new EASO framework may provide a more sensitive tool to diagnose obesity than the traditional BMI definition, but whether these newly identified adults with obesity would benefit comparably to obesity treatment as those traditionally included in treatment trials is uncertain. PRIMARY FUNDING SOURCE: Ariel University and the Holon Institute of Technology, Israel. FAU - Dicker, Dror AU - Dicker D AUID- ORCID: 0000-0001-8546-6245 AD - Internal Medicine D and Obesity Clinic, Hasharon Hospital, Rabin Medical Center, Petah Tikva, and Gray Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel (D.D.). FAU - Karpati, Tomas AU - Karpati T AUID- ORCID: 0000-0003-2650-6192 AD - Department of Digital Technologies in Medicine, Holon Institute of Technology, Holon, Israel (T.K.). FAU - Promislow, Sara AU - Promislow S AUID- ORCID: 0000-0003-3213-3468 AD - Department of Health Systems Management, School of Health Sciences, Ariel University, Ariel, and Israeli Center for Diabetes Research and Policy, Sheba Medical Center, Tel Hashomer, Israel (S.P.). FAU - Reges, Orna AU - Reges O AD - Department of Health Systems Management, School of Health Sciences, Ariel University, Ariel, and Branch of Planning and Strategy, Clalit Health Services, Tel Aviv, Israel (O.R.). LA - eng PT - Journal Article DEP - 20250708 PL - United States TA - Ann Intern Med JT - Annals of internal medicine JID - 0372351 SB - IM MH - Humans MH - *Obesity/epidemiology/mortality/diagnosis/complications/classification MH - Middle Aged MH - Adult MH - Male MH - Body Mass Index MH - Female MH - Cross-Sectional Studies MH - Aged MH - Prevalence MH - United States/epidemiology MH - Nutrition Surveys MH - Young Adult MH - Adolescent MH - Longitudinal Studies MH - Europe/epidemiology MH - Comorbidity MH - Overweight MH - Cause of Death COIS- Disclosures: Disclosure forms are available with the article online. EDAT- 2025/07/07 18:26 MHDA- 2025/08/31 20:03 CRDT- 2025/07/07 17:02 PHST- 2025/08/31 20:03 [medline] PHST- 2025/07/07 18:26 [pubmed] PHST- 2025/07/07 17:02 [entrez] AID - 10.7326/ANNALS-24-02547 [doi] PST - ppublish SO - Ann Intern Med. 2025 Aug;178(8):1065-1072. doi: 10.7326/ANNALS-24-02547. Epub 2025 Jul 8. PMID- 40622132 OWN - NLM STAT- MEDLINE DCOM- 20260316 LR - 20260813 IS - 1308-5735 (Electronic) IS - 1308-5727 (Print) VI - 18 IP - 1 DP - 2026 Mar 13 TI - Comparison of Methods used for Final Height Prediction in Patients with Central Precocious Puberty. PG - 66-73 LID - 10.4274/jcrpe.galenos.2025.2025-2-1 [doi] AB - OBJECTIVE: Various methods may be used to estimate target height in patients diagnosed with precocious puberty. These methods include the Bayley-Pinneau (BP) and Roche-Wainer-Thissen (RWT) methods. In addition to these methods, in our clinic, we routinely use a practical approach based on the percentiles in growth charts. In this method, the bone age percentile is projected to the end of the percentile curve (at 18 years of age) to estimate the final adult height. We have named this method Bone Age Percentile Curve Projected Height Estimation (BAPCPHE). The aim of this study was to retrospectively compare the effectiveness of these three methods in predicting target height in patients treated for central precocious puberty and who have reached their final height in our pediatric endocrinology clinic. METHODS: Fifty female patients were included. The predicted adult heights (PAH) were calculated at treatment initiation, at the end of the first, second, and third years of treatment, and at the time of final height attainment using the BP, RWT, and BAPCPHE methods, based on the patients' heights and bone ages. RESULTS: When the agreement between the PAH calculated by three methods and the final height was analyzed using intraclass correlation coefficient, significant agreement was found for PAH using the BAPCPHE method in the third year. Among the methods, the strongest agreement with final height and PAH was observed with the BP method at the end of treatment, followed by the BAPCPHE method. CONCLUSION: The BAPCPHE method allows estimation of PAH quickly, making it a valuable tool in the outpatient setting. Given its simplicity and accuracy, we find the BAPCPHE method preferable. CI - (c)Copyright 2026 by Turkish Society for Pediatric Endocrinology and Diabetes / The Journal of Clinical Research in Pediatric Endocrinology published by Galenos Publishing House. FAU - Turan, Nisa Nur AU - Turan NN AUID- ORCID: 0009-0006-4917-0766 AD - Istanbul Medeniyet University, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Department of Pediatrics, Istanbul, Turkiye FAU - Camas, Asan Onder AU - Camas AO AUID- ORCID: 0000-0002-5730-3198 AD - Istanbul Medeniyet University, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Department of Pediatric Endocrinology, Istanbul, Turkiye FAU - Cicek, Burcin AU - Cicek B AUID- ORCID: 0009-0001-3196-3251 AD - Istanbul Medeniyet University, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Department of Pediatric Endocrinology, Istanbul, Turkiye FAU - Hepokur, Merve Nur AU - Hepokur MN AUID- ORCID: 0000-0002-5470-1254 AD - Istanbul Medeniyet University, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Department of Pediatric Endocrinology, Istanbul, Turkiye FAU - Emeksiz, Hamdi Cihan AU - Emeksiz HC AUID- ORCID: 0000-0002-4815-1591 AD - Istanbul Medeniyet University, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Department of Pediatric Endocrinology, Istanbul, Turkiye LA - eng PT - Comparative Study PT - Journal Article DEP - 20250707 PL - Turkey TA - J Clin Res Pediatr Endocrinol JT - Journal of clinical research in pediatric endocrinology JID - 101519456 SB - IM MH - Humans MH - *Puberty, Precocious/physiopathology/drug therapy/diagnosis MH - Female MH - *Body Height MH - Retrospective Studies MH - Child MH - *Age Determination by Skeleton/methods MH - Adolescent MH - Growth Charts PMC - PMC12989913 OTO - NOTNLM OT - Bayley-Pinneau OT - Precocious puberty OT - Roche-Wainer-Thissen OT - bone age OT - predicted adult height COIS- None declared. EDAT- 2025/07/07 12:27 MHDA- 2026/03/16 06:31 PMCR- 2026/03/13 CRDT- 2025/07/07 08:57 PHST- 2026/03/16 06:31 [medline] PHST- 2025/07/07 12:27 [pubmed] PHST- 2025/07/07 08:57 [entrez] PHST- 2026/03/13 00:00 [pmc-release] AID - 10.4274/jcrpe.galenos.2025.2025-2-1 [doi] PST - ppublish SO - J Clin Res Pediatr Endocrinol. 2026 Mar 13;18(1):66-73. doi: 10.4274/jcrpe.galenos.2025.2025-2-1. Epub 2025 Jul 7. PMID- 40621260 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250708 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 17 IP - 6 DP - 2025 Jun TI - Mode of Birth and Specific Learning Disabilities: A Systematic Review. PG - e85459 LID - 10.7759/cureus.85459 [doi] LID - e85459 AB - In many countries, including Greece, cesarean section (CS) birth rates have exceeded globally accepted levels and the European average, raising concerns about health risks. CS has been linked to adverse outcomes in children, including obesity, metabolic disorders, type 1 diabetes, and neurodevelopmental conditions. Some research suggests lower cognitive performance in CS-born children compared to vaginally born peers. However, the connection between CS and specific learning disabilities (SLDs) remains unexplained and has yet to be clarified. This systematic review aims to assess studies exploring the potential link between CS and SLDs. A systematic search was conducted in Scopus, PubMed, and ScienceDirect from inception to January 2024, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PROSPERO registration: CRD 42022383362). Relevant keywords were used to identify observational studies, and the Joanna Briggs Institute's Critical Appraisal Checklist was employed to assess methodological quality. From 1,921 screened titles and abstracts, 219 studies were selected for full-text review, and 10 met the inclusion criteria. Most studies used registry data, with some employing interviews or validated tests. Eight studies suggested CS as a possible risk factor for SLDs, but after adjusting for confounders, only two showed statistically significant results. Some studies lacked adjustments, and two studies highlighted the distinction between elective and emergency CS as a potential confounder. Given the limited number of studies and the variability in their findings, the evidence remains inconsistent in supporting a potential association between CS and SLDs. Future research should adopt a multidisciplinary diagnostic approach and emphasize the use of validated tools for diagnosing SLDs, account for confounding variables, and distinguish between elective and emergency CS procedures. CI - Copyright (c) 2025, Makri et al. FAU - Makri, Maria A AU - Makri MA AD - Department of Biomedical Sciences, University of West Attica, Athens, GRC. FAU - Chaniotis, Dimitrios AU - Chaniotis D AD - Department of Biomedical Sciences, University of West Attica, Athens, GRC. FAU - Vivilaki, Victoria V AU - Vivilaki VV AD - Department of Midwifery, University of West Attica, Athens, GRC. FAU - Papageorgiou, Effie G AU - Papageorgiou EG AD - Department of Biomedical Sciences, University of West Attica, Athens, GRC. LA - eng PT - Journal Article PT - Review DEP - 20250606 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC12229086 OTO - NOTNLM OT - cesarean section OT - child development OT - learning difficulties OT - mode of delivery OT - specific learning disabilities OT - vaginal birth COIS- Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2025/07/07 06:26 MHDA- 2025/07/07 06:27 PMCR- 2025/06/06 CRDT- 2025/07/07 05:19 PHST- 2025/06/06 00:00 [accepted] PHST- 2025/07/07 06:27 [medline] PHST- 2025/07/07 06:26 [pubmed] PHST- 2025/07/07 05:19 [entrez] PHST- 2025/06/06 00:00 [pmc-release] AID - 10.7759/cureus.85459 [doi] PST - epublish SO - Cureus. 2025 Jun 6;17(6):e85459. doi: 10.7759/cureus.85459. eCollection 2025 Jun. PMID- 40620573 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250708 IS - 2753-4294 (Electronic) IS - 2753-4294 (Linking) VI - 3 IP - 2 DP - 2025 TI - Prevalence of eating disorders and disordered eating in First Nations Peoples in high-income, colonial settler countries: a scoping review. PG - e002223 LID - 10.1136/bmjph-2024-002223 [doi] LID - e002223 AB - Disordered eating (DE) is often a feature of the eating disorder (ED) prodrome. EDs are complex mental health conditions which affect approximately 4% of Australians. However, research on DE and EDs in Aboriginal and Torres Strait Islander Australians is scarce, with fewer than ten peer-reviewed studies available. These studies suggest Indigenous Australians may experience DE and EDs at equal or higher rates than non-Indigenous Australians. This scoping review aimed to map the literature on the prevalence and presentation of eating disturbances in populations comparable to Indigenous Australians-that is, First Nations Peoples from high-income, colonial settler countries-in order to identify translatable knowledge gaps and research priorities. Following Joanna Briggs Institute (JBI) methodology and PRISMA-ScR guidelines, a systematic literature search of seven databases, data extraction, and narrative synthesis were conducted. Publications in English reporting the prevalence or presentation of DE or EDs among First Nations Peoples in Australia, New Zealand, the United States, Canada, and Scandinavian countries were eligible. Sixty-four publications met eligibility criteria. Lifetime ED prevalence in First Nations adults ranged from 3.3% to 4.3% for females and 0.4% to 2.6% for males. For children/adolescents, prevalence ranged from 10% to 15.6% for females and 4.4% to 5.3% for males. Body mass index, age, self-concept, psychosocial stressors, substance use, and social connection were linked to eating disturbances. Colonisation and racism affect ED experiences and treatment-seeking. Future research must include culturally validated models and tools, with leadership and co-design by Aboriginal and Torres Strait Islander communities. CI - Copyright (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. Published by BMJ Group. FAU - Masters, Ashley AU - Masters A AD - Faculty of Medicine and Health, The University of Sydney School of Rural Health, Dubbo, New South Wales, Australia. AD - South Western Sydney Local Health District, Liverpool, New South Wales, Australia. FAU - Wilkey, Kyar AU - Wilkey K AD - InsideOut Institute for Eating Disorders, University of Sydney and Sydney Local Health District, Camperdown, New South Wales, Australia. AD - Australian Eating Disorders Research and Translation Centre, Sydney, New South Wales, Australia. FAU - Bryant, Emma AU - Bryant E AUID- ORCID: 0000-0003-1918-6020 AD - InsideOut Institute for Eating Disorders, University of Sydney and Sydney Local Health District, Camperdown, New South Wales, Australia. AD - Australian Eating Disorders Research and Translation Centre, Sydney, New South Wales, Australia. FAU - Skinner, John AU - Skinner J AD - Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia. AD - Sydney Institute for Women, Children and their Families, Sydney Local Health District, Sydney, New South Wales, Australia. FAU - Darwin, Leilani AU - Darwin L AD - Australian Eating Disorders Research and Translation Centre, Sydney, New South Wales, Australia. AD - First Nations Co, Brisbane, Queensland, Australia. FAU - Parter, Carmen AU - Parter C AD - Nura Gili, University of New South Wales, Kensington, New South Wales, Australia. AD - Djurali Centre for Aboriginal and Torres Strait Islander Research and Education, Heart Research Institute, Sydney, New South Wales, Australia. FAU - Gwynne, Kylie AU - Gwynne K AD - Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia. AD - University of New South Wales, Kensington, New South Wales, Australia. FAU - Marks, Peta AU - Marks P AD - InsideOut Institute for Eating Disorders, University of Sydney and Sydney Local Health District, Camperdown, New South Wales, Australia. AD - Australian Eating Disorders Research and Translation Centre, Sydney, New South Wales, Australia. FAU - Calma, Tom AU - Calma T AD - Poche Centre for Indigenous Health, University of Sydney, Sydney, New South Wales, Australia. FAU - Maguire, Sarah AU - Maguire S AD - InsideOut Institute for Eating Disorders, University of Sydney and Sydney Local Health District, Camperdown, New South Wales, Australia. AD - Australian Eating Disorders Research and Translation Centre, Sydney, New South Wales, Australia. FAU - Rambaldini, Boe AU - Rambaldini B AD - Nura Gili, University of New South Wales, Kensington, New South Wales, Australia. AD - Djurali Centre for Aboriginal and Torres Strait Islander Research and Education, Heart Research Institute, Sydney, New South Wales, Australia. LA - eng PT - Journal Article PT - Review DEP - 20250705 PL - England TA - BMJ Public Health JT - BMJ public health JID - 9918697578906676 PMC - PMC12228441 OTO - NOTNLM OT - Community Health OT - Epidemiology OT - Mental Health OT - Public Health OT - Scoping Review COIS- None declared. EDAT- 2025/07/07 06:26 MHDA- 2025/07/07 06:27 PMCR- 2025/07/05 CRDT- 2025/07/07 05:08 PHST- 2024/10/22 00:00 [received] PHST- 2025/06/05 00:00 [accepted] PHST- 2025/07/07 06:27 [medline] PHST- 2025/07/07 06:26 [pubmed] PHST- 2025/07/07 05:08 [entrez] PHST- 2025/07/05 00:00 [pmc-release] AID - bmjph-2024-002223 [pii] AID - 10.1136/bmjph-2024-002223 [doi] PST - epublish SO - BMJ Public Health. 2025 Jul 5;3(2):e002223. doi: 10.1136/bmjph-2024-002223. eCollection 2025. PMID- 40619317 OWN - NLM STAT- MEDLINE DCOM- 20250828 LR - 20260511 IS - 1878-3562 (Electronic) IS - 1590-8658 (Linking) VI - 57 IP - 9 DP - 2025 Sep TI - Synergistic effects of oral exclusive enteral nutrition and biologics in induction therapy for adult Crohn's disease: A real-world observational study. PG - 1778-1786 LID - S1590-8658(25)00832-1 [pii] LID - 10.1016/j.dld.2025.06.014 [doi] AB - BACKGROUND: Exclusive enteral nutrition (EEN) is recommended as first-line induction therapy for pediatric Crohn's disease (CD), but its use in adults, especially alongside biologics, is limited. This study evaluated the effectiveness of a structured oral EEN approach combined with biologics as induction therapy in adult active CD. METHODS: A total of 242 biologically treated adult CD patients were retrospectively enrolled after propensity score matching and divided into combined-EEN (n = 121) and non-EEN (n = 121) groups. Clinical and endoscopic outcomes, body composition, pharmacokinetics, and cytokine levels were assessed. RESULTS: The combined-EEN group showed superior outcomes, with higher endoscopic response (69.4 % vs. 37.2 %, P < 0.001) and remission rates (36.4 % vs. 21.5 %, P = 0.011). They also demonstrated improved skeletal muscle index (P = 0.038) and normalized fat distribution. Infliximab concentrations were higher in this group (3.3 vs. 1.7 mg/dl, P = 0.048), and levels of IL-1beta, IL-6, and TNF-alpha were significantly reduced (all P < 0.05). CONCLUSIONS: EEN combined with biologics enhances induction therapy outcomes in adult CD, contributing to improved body composition recovery, optimized pharmacokinetics of biologics, and reduced levels of inflammatory cytokines. These findings support the broader implementation of EEN in adult CD management and warrant further validation in multicenter clinical trials. CI - Copyright (c) 2025 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. FAU - Song, Yangda AU - Song Y AD - Inflammatory Bowel Diseases Research Center, Department of Gastroenterology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Centre for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Peng, Yong AU - Peng Y AD - Inflammatory Bowel Diseases Research Center, Department of Gastroenterology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Centre for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Fan, Xiujin AU - Fan X AD - Inflammatory Bowel Diseases Research Center, Department of Gastroenterology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Centre for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Shi, Li AU - Shi L AD - Department of Radiology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Centre for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Wang, Shanping AU - Wang S AD - Inflammatory Bowel Diseases Research Center, Department of Gastroenterology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Centre for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Zhang, Haonan AU - Zhang H AD - Inflammatory Bowel Diseases Research Center, Department of Gastroenterology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Centre for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Lin, Chuangzhen AU - Lin C AD - Inflammatory Bowel Diseases Research Center, Department of Gastroenterology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Centre for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. FAU - He, Chengcheng AU - He C AD - Inflammatory Bowel Diseases Research Center, Department of Gastroenterology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Centre for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Qing, Qing AU - Qing Q AD - Inflammatory Bowel Diseases Research Center, Department of Gastroenterology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Centre for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Sun, Yan AU - Sun Y AD - Inflammatory Bowel Diseases Research Center, Department of Gastroenterology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Centre for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Li, Mingsong AU - Li M AD - Inflammatory Bowel Diseases Research Center, Department of Gastroenterology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Centre for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China; Department of Gastroenterology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. Electronic address: lims661216@163.com. LA - eng PT - Journal Article PT - Observational Study DEP - 20250705 PL - Netherlands TA - Dig Liver Dis JT - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JID - 100958385 RN - 0 (Biological Products) RN - B72HH48FLU (Infliximab) RN - 0 (Cytokines) SB - IM MH - Humans MH - *Crohn Disease/therapy MH - Adult MH - *Enteral Nutrition/methods MH - Male MH - Female MH - Retrospective Studies MH - *Biological Products/therapeutic use MH - Treatment Outcome MH - Infliximab/therapeutic use/pharmacokinetics MH - Remission Induction MH - Young Adult MH - Middle Aged MH - Propensity Score MH - Combined Modality Therapy MH - Induction Chemotherapy MH - Cytokines/blood OTO - NOTNLM OT - Body composition OT - Crohn's disease OT - Exclusive enteral nutrition OT - Induction therapy COIS- Conflict of interest All the authors have no conflicts of interest to declare. EDAT- 2025/07/07 00:26 MHDA- 2025/09/08 08:04 CRDT- 2025/07/06 22:19 PHST- 2025/05/05 00:00 [received] PHST- 2025/06/18 00:00 [revised] PHST- 2025/06/19 00:00 [accepted] PHST- 2025/09/08 08:04 [medline] PHST- 2025/07/07 00:26 [pubmed] PHST- 2025/07/06 22:19 [entrez] AID - S1590-8658(25)00832-1 [pii] AID - 10.1016/j.dld.2025.06.014 [doi] PST - ppublish SO - Dig Liver Dis. 2025 Sep;57(9):1778-1786. doi: 10.1016/j.dld.2025.06.014. Epub 2025 Jul 5. PMID- 40618451 OWN - NLM STAT- MEDLINE DCOM- 20250714 LR - 20250714 IS - 1873-4138 (Electronic) IS - 0309-1740 (Linking) VI - 228 DP - 2025 Oct TI - Framing the meat consumption transition: A statistical learning approach to explore the factors shaping young adults' food choices in Germany and Italy. PG - 109899 LID - S0309-1740(25)00160-3 [pii] LID - 10.1016/j.meatsci.2025.109899 [doi] AB - This study examines the factors driving changes in meat consumption among young adults in Germany and Italy-two high-income countries that, despite their distinct culinary traditions, have seen a convergence in meat consumption levels in recent years. The research addresses two aims: to examine the role of environmental attitudes in shaping dietary choices and to explore the impact of socio-demographic factors on meat-consumption patterns. The analysis employs the General Ecological Behavior (GEB) scale, a robust tool that provides a comprehensive assessment of pro-environmental attitudes as latent traits influencing behavior. It is complemented by the Random Forest, a machine learning algorithm that helps exploring complex, non-linear relationships among predictors. Data were collected from 580 respondents aged 18-30 through an online survey. The results reveal that environmental attitude is the strongest predictor of dietary habits, followed by household composition. German respondents, with higher environmental attitudes, were more likely to adopt vegetarian or vegan diets, whereas Italian respondents, influenced also by family dynamics, tended towards meat-based or flexitarian diets. These findings highlight the importance of gaining a deeper understanding of the underlying motivations behind the transition to a flexitarian diet, which could serve as a model for the future of meat consumption in Europe. CI - Copyright (c) 2024. Published by Elsevier Ltd. FAU - Peri, Massimo AU - Peri M AD - Department of Environmental Science and Policy, University of Milan, via Celoria 2, 20133 Milan, Italy. FAU - Trentinaglia, Maria Teresa AU - Trentinaglia MT AD - Department of Environmental Science and Policy, University of Milan, via Celoria 2, 20133 Milan, Italy. Electronic address: maria.trentinaglia@unimi.it. FAU - Adler, Maximilian AU - Adler M AD - Institute of Psychology, Otto-von-Guericke-Universitat Magdeburg, Germany. FAU - Zanaboni, Anna Maria AU - Zanaboni AM AD - Department of Computer Science, University of Milan, via Celoria 18, 20133 Milan, Italy; Data Science Research Center (DSRC) - University of Milan, Italy. FAU - Baldi, Lucia AU - Baldi L AD - Department of Environmental Science and Policy, University of Milan, via Celoria 2, 20133 Milan, Italy. LA - eng PT - Journal Article DEP - 20250702 PL - England TA - Meat Sci JT - Meat science JID - 101160862 SB - IM MH - Humans MH - Adult MH - Young Adult MH - Male MH - Italy MH - Female MH - Adolescent MH - *Meat MH - Germany MH - *Food Preferences/psychology MH - *Diet MH - Choice Behavior MH - Diet, Vegetarian MH - Machine Learning MH - Surveys and Questionnaires MH - Feeding Behavior MH - Attitude MH - Socioeconomic Factors OTO - NOTNLM OT - Cross-cultural analysis OT - Dietary patterns OT - Machine learning OT - Pro-environmental behavior OT - Psychometric assessment OT - Sustainable consumption COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/07/07 00:26 MHDA- 2025/07/15 00:30 CRDT- 2025/07/06 18:01 PHST- 2025/02/20 00:00 [received] PHST- 2025/06/26 00:00 [revised] PHST- 2025/06/30 00:00 [accepted] PHST- 2025/07/15 00:30 [medline] PHST- 2025/07/07 00:26 [pubmed] PHST- 2025/07/06 18:01 [entrez] AID - S0309-1740(25)00160-3 [pii] AID - 10.1016/j.meatsci.2025.109899 [doi] PST - ppublish SO - Meat Sci. 2025 Oct;228:109899. doi: 10.1016/j.meatsci.2025.109899. Epub 2025 Jul 2. PMID- 40616488 OWN - NLM STAT- MEDLINE DCOM- 20250705 LR - 20250705 IS - 2214-0190 (Electronic) IS - 0895-3988 (Linking) VI - 38 IP - 6 DP - 2025 Jun 20 TI - Exploration of New Susceptible Genes associated with Non-Alcoholic Fatty Liver Disease among Children with Obesity Using Whole Exome Sequencing. PG - 727-739 LID - 10.3967/bes2025.045 [doi] AB - OBJECTIVE: This study aimed to evaluate the association between susceptibility genes and non-alcoholic fatty liver disease (NAFLD) in children with obesity. METHODS: We conducted a two-step case-control study. Ninety-three participants were subjected to whole-exome sequencing (exploratory set). Differential genes identified in the small sample were validated in 1,022 participants using multiplex polymerase chain reaction and high-throughput sequencing (validation set). RESULTS: In the exploratory set, 14 genes from the NAFLD-associated pathways were identified. In the validation set, after adjusting for sex, age, and body mass index, ECI2 rs2326408 (dominant model: OR = 1.33, 95% CI: 1.02-1.72; additive model: OR = 1.22, 95% CI: 1.01-1.47), C6orf201 rs659305 (dominant model: OR = 1.30, 95% CI: 1.01-1.69; additive model: OR = 1.21, 95% CI: 1.00-1.45), CALML5 rs10904516 (pre-ad dominant model: OR = 1.36, 95% CI: 1.01-1.83; adjusted dominant model: OR = 1.40, 95% CI: 1.03-1.91; and pre-ad additive model: OR = 1.26, 95% CI: 1.04-1.66) polymorphisms were significantly associated with NAFLD in children with obesity ( P < 0.05). Interaction analysis revealed that the gene-gene interaction model of CALML5 rs10904516, COX11 rs17209882, and SCD5 rs3733228 was optional ( P < 0.05), demonstrating a negative interaction between the three genes. CONCLUSION: In the Chinese population, the CALML5 rs10904516, C6orf201 rs659305, and ECI2 rs2326408 variants could be genetic markers for NAFLD susceptibility. CI - Copyright (c) 2025 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved. FAU - Pan, Xiong Feng AU - Pan XF AD - Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410008, Hunan, China;Pediatrics Research Institute of Hunan Province, Hunan Children's Hospital, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University, Changsha 410008, Hunan, China;The School of Pediatrics, Hunan Provincial Key Laboratory of Pediatric Orthopedics, The school of pediatrics, University of South China, Changsha 410008, Hunan, China. FAU - Wei, Cai Lian AU - Wei CL AD - Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410008, Hunan, China. FAU - Luo, Jia You AU - Luo JY AD - Department of Child and Adolescent Health and Maternal and Child Health, Xiangya School of Public Health, Central South University, Changsha 410008, Hunan, China. FAU - Yan, Jun Xia AU - Yan JX AD - Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410008, Hunan, China. FAU - Xiao, Xiang AU - Xiao X AD - Department of Child and Adolescent Health and Maternal and Child Health, Xiangya School of Public Health, Central South University, Changsha 410008, Hunan, China. FAU - Wang, Jie AU - Wang J AD - Supervision and Inspection Department of Shanghai Healthcare Security Bureau, Shanghai 200003, China. FAU - Zhong, Yan AU - Zhong Y AD - Children's Health Center, Hunan Children's Hospital, Changsha 410008, Hunan, China. FAU - Luo, Mi Yang AU - Luo MY AD - Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410008, Hunan, China. LA - eng PT - Journal Article PL - China TA - Biomed Environ Sci JT - Biomedical and environmental sciences : BES JID - 8909524 SB - IM MH - Humans MH - *Non-alcoholic Fatty Liver Disease/genetics MH - Child MH - Male MH - Female MH - *Genetic Predisposition to Disease MH - Case-Control Studies MH - Exome Sequencing MH - Adolescent MH - Polymorphism, Single Nucleotide MH - *Obesity/genetics/complications MH - *Pediatric Obesity/genetics/complications MH - China OTO - NOTNLM OT - Interaction OT - Non-alcoholic fatty liver disease OT - Obese children OT - Single nucleotide polymorphism OT - Susceptible genes OT - Whole-exome sequencing EDAT- 2025/07/05 20:45 MHDA- 2025/07/05 20:46 CRDT- 2025/07/05 09:02 PHST- 2024/06/21 00:00 [received] PHST- 2025/01/07 00:00 [accepted] PHST- 2025/07/05 20:46 [medline] PHST- 2025/07/05 20:45 [pubmed] PHST- 2025/07/05 09:02 [entrez] AID - 10.3967/bes2025.045 [doi] PST - ppublish SO - Biomed Environ Sci. 2025 Jun 20;38(6):727-739. doi: 10.3967/bes2025.045. PMID- 40616220 OWN - NLM STAT- MEDLINE DCOM- 20260218 LR - 20260902 IS - 1098-2353 (Electronic) IS - 0897-3806 (Print) IS - 0897-3806 (Linking) VI - 39 IP - 2 DP - 2026 Mar TI - Characterization of Healthy Pancreas Morphology Throughout Childhood. PG - 156-164 LID - 10.1002/ca.70003 [doi] AB - Pancreas shape features, derived from 3D segmentation of the pancreas, might be relevant to identifying subtle disease-related changes in the pancreas. This work utilized a retrospective sample of clinical contrast-enhanced CT examinations of 140 children < 18 years of age. Manual segmentations of the pancreas were used to extract radiomic shape features and perform statistical shape modeling using a partial least squares regression approach. Age, weight, height, body surface area, and body mass index each showed significant associations with volume, surface area, surface area to volume ratio, compactness, major axis length, minor axis length, least axis length, and area density. Elastic net regression models showed that demographic variables had strong predictive power (cross-validated r(2) 0.71-0.89) for pancreas volume, surface area, surface area to volume ratio, major axis length, minor axis length, and least axis length. In the analysis of shape modes, only the first partial least squares regression component accounted for a statistically significant amount of the demographic variance among participants (24.8% variance explained, p < 0.001), with significant loadings for age (p < 0.001), weight (p = 0.001), and height (p < 0.001). Our results are the first to characterize pancreas shape features in children with healthy pancreatic function and set the stage for future studies to understand how disease impacts pancreas shape, beyond global changes in volume, and how changes in shape might be used to diagnose and monitor disease. CI - (c) 2025 American Association of Clinical Anatomists and British Association of Clinical Anatomists. FAU - Dudley, Jonathan A AU - Dudley JA AUID- ORCID: 0000-0002-5189-9568 AD - Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. FAU - Murdock, Kyle E AU - Murdock KE AD - Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. FAU - Qiu, Lisa AU - Qiu L AD - Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. FAU - Abu-El-Haija, Maisam AU - Abu-El-Haija M AD - Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. AD - Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA. FAU - Trout, Andrew T AU - Trout AT AD - Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. LA - eng GR - R01 DK132346/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20250704 PL - United States TA - Clin Anat JT - Clinical anatomy (New York, N.Y.) JID - 8809128 SB - IM MH - Humans MH - Child MH - *Pancreas/diagnostic imaging/anatomy & histology MH - Male MH - Female MH - Child, Preschool MH - Retrospective Studies MH - Adolescent MH - Tomography, X-Ray Computed MH - Infant MH - Imaging, Three-Dimensional PMC - PMC13531879 MID - NIHMS2175256 OTO - NOTNLM OT - computed tomography OT - development OT - morphology OT - pancreas OT - radiomics EDAT- 2025/07/05 20:45 MHDA- 2026/02/18 10:07 PMCR- 2026/09/01 CRDT- 2025/07/05 00:32 PHST- 2025/05/12 00:00 [revised] PHST- 2025/03/06 00:00 [received] PHST- 2025/05/31 00:00 [accepted] PHST- 2026/02/18 10:07 [medline] PHST- 2025/07/05 20:45 [pubmed] PHST- 2025/07/05 00:32 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - 10.1002/ca.70003 [doi] PST - ppublish SO - Clin Anat. 2026 Mar;39(2):156-164. doi: 10.1002/ca.70003. Epub 2025 Jul 4. PMID- 40616100 OWN - NLM STAT- MEDLINE DCOM- 20250705 LR - 20250709 IS - 1471-2474 (Electronic) IS - 1471-2474 (Linking) VI - 26 IP - 1 DP - 2025 Jul 4 TI - Construct validity of the international physical activity questionnaire using accelerometry data in patients with femoroacetabular impingement Syndrome and Acetabular Dysplasia: a cross-sectional analysis. PG - 610 LID - 10.1186/s12891-025-08860-0 [doi] LID - 610 AB - BACKGROUND: The International Physical Activity Questionnaire (IPAQ) is widely used to assess physical activity (PA), but its validity compared to device-measured PA data in patients with Femoroacetabular Impingement Syndrome (FAIS) and Acetabular Dysplasia (AD) remains underexplored. We evaluated the convergent and divergent aspects of construct validity of self-reported PA via the IPAQ versus accelerometry data in patients with pre-arthritic hip diseases (FAIS, AD). METHODS: Participants with FAIS or AD, aged 18 and older, completed the IPAQ and wore accelerometers for 7 days. We compared IPAQ-reported moderate-to-vigorous physical activity (MVPA) with accelerometer-measured sedentary behavior, light PA, and MVPA using Pearson correlations and Bland-Altman plots. RESULTS: Fifty-four individuals with FAIS or AD participated. We did not find any significant correlations between IPAQ-MVPA and accelerometer-measured PA variables. Bland-Altman plots revealed a positive systematic bias between IPAQ-MVPA scores and accelerometer-measured MVPA. CONCLUSIONS: The IPAQ-MVPA scores showed divergent validity compared to accelerometer data in individuals with FAIS and AD. Future studies should integrate both self-report and device-based measures to enhance accuracy. CI - (c) 2025. The Author(s). FAU - Alrashdi, Naif Z AU - Alrashdi NZ AD - Department of Physical Therapy and Health Rehabilitation, College of Applied Medical Sciences, Majmaah University, 11952, AL-Majmaah, Saudi Arabia. AD - Health and Basic Sciences Research Center, Majmaah University, 11952, AL-Majmaah, Saudi Arabia. FAU - Alotaibi, Mansour M AU - Alotaibi MM AD - Department of Rehabilitation, Faculty of Applied Medical Sciences, Northern Border University, Arar, Saudi Arabia. mansour.alotaibi@nbu.edu.sa. AD - Center for Health Research, Northern Border University, Arar, Saudi Arabia. mansour.alotaibi@nbu.edu.sa. FAU - Aguiar, Elroy J AU - Aguiar EJ AD - Department of Kinesiology, The University of Alabama, Tuscaloosa, AL, USA. FAU - Ryan, Michael K AU - Ryan MK AD - The Hip Center at Andrews Sports Medicine and Orthopaedic Center, Birmingham, AL, USA. AD - American Sports Medicine Institute, Birmingham, AL, USA. FAU - Ithurburn, Matthew P AU - Ithurburn MP AD - American Sports Medicine Institute, Birmingham, AL, USA. AD - School of Health Professions, University of Alabama at Birmingham, Birmingham, AL, USA. LA - eng GR - R-202X-XXXX/Majmaah University/ GR - NBU-FFR-2025-2508-XX/Northern Border University/ PT - Journal Article PT - Validation Study DEP - 20250704 PL - England TA - BMC Musculoskelet Disord JT - BMC musculoskeletal disorders JID - 100968565 SB - IM MH - Humans MH - *Femoracetabular Impingement/diagnosis/physiopathology MH - Male MH - Female MH - *Accelerometry/methods/standards MH - Cross-Sectional Studies MH - Adult MH - Middle Aged MH - *Exercise/physiology MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Young Adult MH - Self Report MH - *Acetabulum/abnormalities MH - Adolescent PMC - PMC12231909 OTO - NOTNLM OT - Accelerometers OT - FAI OT - Hip OT - Hip dysplasia OT - Reliability COIS- Declarations. Ethics approval and consent to participate: We obtained ethical approval for this study from the University of Alabama at Birmingham institutional review board (Protocols IRB:300004519 and IRB: 300001355) prior to study initiation, and that all participants provided written informed consent before participating in this study. Competing interests: The authors declare no competing interests. EDAT- 2025/07/05 00:28 MHDA- 2025/07/05 20:45 PMCR- 2025/07/04 CRDT- 2025/07/04 23:51 PHST- 2025/02/13 00:00 [received] PHST- 2025/06/05 00:00 [accepted] PHST- 2025/07/05 20:45 [medline] PHST- 2025/07/05 00:28 [pubmed] PHST- 2025/07/04 23:51 [entrez] PHST- 2025/07/04 00:00 [pmc-release] AID - 10.1186/s12891-025-08860-0 [pii] AID - 8860 [pii] AID - 10.1186/s12891-025-08860-0 [doi] PST - epublish SO - BMC Musculoskelet Disord. 2025 Jul 4;26(1):610. doi: 10.1186/s12891-025-08860-0. PMID- 40615643 OWN - NLM STAT- MEDLINE DCOM- 20250704 LR - 20250825 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Jul 4 TI - Physical activity and internalization problems in middle school students: the chain mediating role of rumination thinking and peer acceptance. PG - 23976 LID - 10.1038/s41598-025-09202-9 [doi] LID - 23976 AB - This study explores methods to improve internalizing problems in middle school students through physical exercise, aiming to construct a mediational model that includes physical exercise, Rumination, peer acceptance, and internalizing problems. The model examines the interactions and influence pathways among these variables to provide a more comprehensive understanding of the mechanism through which physical exercise impacts internalizing problems in middle school students. 671 junior high school students were surveyed by physical exercise scale, Rumination scale, peer acceptance scale and internalization question scale. SPSS26.0 was used to analyze the data, followed by descriptive analysis, reliability analysis, Pearson correlation analysis, Harman single factor test and Bootstrap analysis. (1) Physical exercise was negatively correlated with internalizing problems (r = - 0.286), but the direct path between physical exercise and internalizing problems was not statistically significant (beta = - 0.060, p > 0.05, CI [- 0.137, 0.018]); (2) Physical exercise was significantly negatively correlated with Rumination (beta = - 0.174, p < 0.001, CI [- 0.255, - 0.094]) and significantly positively correlated with peer acceptance (beta = 0.357, p < 0.001, CI [0.286, 0.429]). Rumination was significantly negatively correlated with peer acceptance (beta = - 0.128, p < 0.001, CI [- 0.199, - 0.056]) and significantly positively correlated with internalizing problems (beta = 0.289, p < 0.001, CI [0.222, 0.356]); peer acceptance was significantly negatively correlated with internalizing problems (beta = - 0.372, p < 0.001, CI [- 0.448, - 0.296]). (3) The total effect of the chain mediation model was - 0.251, and the direct effect of physical exercise and internalized problems was - 0.059,The total effect accounted for 23.51%, Rumination and Peer acceptance played a mediating role between physical exercise and internalized behavior problems, and the total indirect effect size was - 0.192, The total effect accounted for 76.49%. The mediating effect values of Rumination and Peer acceptance between physical exercise and internalized behavior problems were - 0.050 and - 0.133, accounting for 19.92% and 52.99%, respectively. The chain-mediated effect between Rumination and Peer acceptance between physical exercise and internalized behavior problems was - 0.008, and the chain-mediated effect accounted for 3.19%. Physical exercise is negatively correlated with internalization, Rumination is negatively correlated with peer acceptance; Rumination and peer acceptance, as mediating variables, not only play an independent mediating role between physical exercise and junior high school students' internalization problems, but also further strengthen their role in junior high school students' internalization problems through chain mediation. Although the effect value of chain mediation is small, it is worthy of attention, suggesting that there is a synergistic effect among the variables. The results of this study provide an important reference for the design of school physical exercise curriculum. Through reasonable design of physical education curriculum, the interest and attraction of physical exercise can be increased, and the participation of students can be improved indirectly, thus promoting the improvement of internalization problems. At the same time, it can be considered to combine physical exercise with mental health education, and cultivate students' methods and abilities to cope with pressure and negative emotions through physical exercise courses, cultivate positive and optimistic attitude, and improve junior middle school students' mental toughness and social adaptability. CI - (c) 2025. The Author(s). FAU - Guo, Kelei AU - Guo K AD - School of Physical Education and Health, Zhaoqing University, Zhaoqing, China. FAU - Chen, Shengyong AU - Chen S AD - School of Physical Education and Health, Zhaoqing University, Zhaoqing, China. FAU - Hui, Zhen AU - Hui Z AD - School of Marxism, Zhaoqing University, Zhaoqing, China. 251360882@qq.com. FAU - Guo, Feng AU - Guo F AD - School of Physical Education, Guang Dong Technology College, Zhaoqing, China. 147385276@qq.com. FAU - Xiang, Jun AU - Xiang J AD - School of Physical Education and Health, Zhaoqing University, Zhaoqing, China. FAU - Li, Dong AU - Li D AD - School of Physical Education and Health, Zhaoqing University, Zhaoqing, China. Lidong58999@163.com. LA - eng PT - Journal Article DEP - 20250704 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM EIN - Sci Rep. 2025 Aug 20;15(1):30602. doi: 10.1038/s41598-025-16372-z. PMID: 40836060 MH - Humans MH - Male MH - Female MH - Adolescent MH - *Exercise/psychology MH - *Students/psychology MH - *Peer Group MH - *Rumination, Cognitive MH - Schools MH - Surveys and Questionnaires MH - Child MH - Thinking PMC - PMC12227635 OTO - NOTNLM OT - Internalizing problems OT - Middle school students OT - Peer acceptance OT - Physical exercise OT - Rumination COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval and consent to participate: This study was reviewed and approved by the Academic Committee of the School of Physical Education and Health, Zhaoqing University. Informed consent was obtained from all individual participants included in the study. For participants who were under 16 years of age, informed consent was obtained from their parents or legal guardians. Further details on the consent process are provided in the supplementary material. EDAT- 2025/07/05 00:28 MHDA- 2025/07/05 00:29 PMCR- 2025/07/04 CRDT- 2025/07/04 23:30 PHST- 2025/03/03 00:00 [received] PHST- 2025/06/25 00:00 [accepted] PHST- 2025/07/05 00:29 [medline] PHST- 2025/07/05 00:28 [pubmed] PHST- 2025/07/04 23:30 [entrez] PHST- 2025/07/04 00:00 [pmc-release] AID - 10.1038/s41598-025-09202-9 [pii] AID - 9202 [pii] AID - 10.1038/s41598-025-09202-9 [doi] PST - epublish SO - Sci Rep. 2025 Jul 4;15(1):23976. doi: 10.1038/s41598-025-09202-9. PMID- 40613897 OWN - NLM STAT- MEDLINE DCOM- 20251024 LR - 20261010 IS - 1432-2161 (Electronic) IS - 0364-2348 (Linking) VI - 54 IP - 12 DP - 2025 Dec TI - Dynamic ultrasound evaluation of patients with suspected slipping rib syndrome: five years in. PG - 2777-2786 LID - 10.1007/s00256-025-04961-y [doi] AB - OBJECTIVE: To evaluate the efficacy of a dynamic ultrasound-based diagnostic protocol designed to improve the diagnosis of slipping rib syndrome in the largest cohort of pediatric patients to date. MATERIALS AND METHODS: A retrospective chart review was conducted for patients who presented to Phoenix Children's Hospital with suspected slipping rib syndrome who underwent dynamic ultrasound-based evaluation from March of 2017 to May of 2022. A focused history and detailed imaging were performed, and dynamic ultrasound exam was conducted and compared with surgical and physical exam findings from pediatric surgeons specializing in slipping rib syndrome. Statistical analyses were performed. RESULTS: Two hundred twenty-seven patients were evaluated for slipping rib syndrome during the study period, resulting in 301 ultrasound evaluations, with 78% of patients undergoing a single evaluation and 22% undergoing multiple assessments. There were 159 (70%) female and 68 (30%) male subjects. Average age and BMI were 17.4 years and 22.4 kg/m(2), respectively. Dynamic ultrasound accurately detected slipping rib in 97.4% (220/226; 94.3%, 99.0%) and correctly found no evidence in 88.7% (63/71; 79.0%, 95.0%) of studies, respectively. The combined right and left-sided sensitivity and specificity for morphology was 55.1% (50.2%, 60.0%) and 88.0% (83.0%, 92.9%); for the crunch maneuver, was 54.1% (49.2%, 59.0%) and 92.6% (88.6%, 96.6%); and, for the push maneuver, was 54.8% (50.0%, 59.7%) and 90.7% (86.2%, 95.2%). CONCLUSION: Dynamic ultrasound imaging of the ribs is an effective and reproducible tool for the diagnosis of slipping rib syndrome, demonstrating high sensitivity and specificity in pediatric patients. CI - (c) 2025. The Author(s), under exclusive licence to International Skeletal Society (ISS). FAU - Schultz, Nicholas AU - Schultz N AUID- ORCID: 0000-0002-3510-7006 AD - University of Arizona, College of Medicine - Phoenix, 475 N. 5 th Street, Phoenix, AZ, 85004, USA. nrschultz@arizona.edu. FAU - Qubain, Leeann AU - Qubain L AD - University of Arizona, College of Medicine - Phoenix, 475 N. 5 th Street, Phoenix, AZ, 85004, USA. FAU - Riemann, Monique AU - Riemann M AD - Department of Radiology, Phoenix Children's Hospital, Phoenix, AZ, USA. FAU - Temkit, M'hamed AU - Temkit M AD - Department of Clinical Research Adminstration, Phoenix Children's Hospital, Phoenix, AZ, USA. FAU - McMahon, Lisa E AU - McMahon LE AD - Department of Surgery, Phoenix Children's Hospital, Phoenix, AZ, USA. FAU - Van Tassel, Dane AU - Van Tassel D AD - Department of Radiology, Phoenix Children's Hospital, Phoenix, AZ, USA. LA - eng PT - Journal Article DEP - 20250704 PL - Germany TA - Skeletal Radiol JT - Skeletal radiology JID - 7701953 SB - IM MH - Humans MH - Male MH - Female MH - Ultrasonography/methods MH - Retrospective Studies MH - Sensitivity and Specificity MH - *Ribs/diagnostic imaging MH - Adolescent MH - Child MH - Syndrome MH - Child, Preschool MH - Infant OTO - NOTNLM OT - Abdominal pain OT - Chest pain OT - Dynamic ultrasound OT - Rib pain OT - Slipping rib syndrome COIS- Declarations. Ethical approval and consent: Approval from the Institutional Review Board was obtained and in keeping with the policies for a retrospective review, informed consent was not required. Conflicts of interest: The authors declare that they have no conflicts of interest. EDAT- 2025/07/04 12:43 MHDA- 2025/10/24 12:30 CRDT- 2025/07/04 11:13 PHST- 2024/09/24 00:00 [received] PHST- 2025/05/23 00:00 [accepted] PHST- 2025/03/28 00:00 [revised] PHST- 2025/10/24 12:30 [medline] PHST- 2025/07/04 12:43 [pubmed] PHST- 2025/07/04 11:13 [entrez] AID - 10.1007/s00256-025-04961-y [pii] AID - 10.1007/s00256-025-04961-y [doi] PST - ppublish SO - Skeletal Radiol. 2025 Dec;54(12):2777-2786. doi: 10.1007/s00256-025-04961-y. Epub 2025 Jul 4. PMID- 40613392 OWN - NLM STAT- MEDLINE DCOM- 20250704 LR - 20250709 IS - 1365-2214 (Electronic) IS - 0305-1862 (Print) IS - 0305-1862 (Linking) VI - 51 IP - 4 DP - 2025 Jul TI - Beyond the (Log)book: Comparing Accelerometer Nonwear Detection Techniques in Toddlers. PG - e70133 LID - 10.1111/cch.70133 [doi] LID - e70133 AB - BACKGROUND: Accelerometers are increasingly used to measure physical activity and sedentary time in toddlers. Data cleaning or wear time validation can impact outcomes of interest, particularly in young children who spend less time awake. However, no study has systematically compared wear time validation strategies in toddlers. As such, the objective of this study is to compare different fully automated methods of distinguishing wear and nonwear time (counts and raw data algorithms) methods to the semi automated (counts with logbooks) criterion method in toddlers. METHODS: We recruited 109 toddlers (age 12-35 months) as part of the iPLAY study to wear an ActiGraph w-GT3X-BT accelerometer on the right hip for ~7 consecutive days (removed for sleep and water activities). Parents completed a logbook to indicate monitor removal and nap times. We tested 15 nonwear detection methods grouped into four main categories: semi-automated logbook, consecutive 0 counts, modified consecutive 0 counts (Troiano and Choi) and raw data methods (van Hees and Ahmadi). Using semi-automated logbooks as the criterion standard (all wear and wake-time only wear), we calculated the accuracy and F1 scores (a metric which balances precision and recall) and compared overall wear time with a two one-sided test of equivalence. RESULTS: Participant daily wear time ranged from 556 to 684 min/day depending on method. Accuracy and F1 score ranged from 86% to 95%. Five methods were considered equivalent to the AllWear nonwear criterion (true wear time including sleep-time wear), with only one equivalent to the AwakeWear criterion. Mean absolute differences were lower for the AllWear criterion but ranged from 49 to 192 min/day. CONCLUSIONS: The 5min0count, 10min_0count, 30min_0count, Troiano60s and Ahmadi methods provide high accuracy and equivalency when compared with semi-automated cleaning using logbooks. This paper provides insights and quantitative results that can help researchers decide which method may be the most appropriate given their population of interest, sample size and study protocol. CI - (c) 2025 The Author(s). Child: Care, Health and Development published by John Wiley & Sons Ltd. FAU - Letts, Elyse AU - Letts E AUID- ORCID: 0000-0002-2543-8346 AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Canada. FAU - da Silva, Sarah M AU - da Silva SM AUID- ORCID: 0009-0001-9512-9776 AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Canada. FAU - Di Cristofaro, Natascja AU - Di Cristofaro N AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Canada. FAU - King-Dowling, Sara AU - King-Dowling S AUID- ORCID: 0000-0003-3670-8425 AD - Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FAU - Obeid, Joyce AU - Obeid J AUID- ORCID: 0000-0002-6209-1505 AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Canada. AD - Department of Kinesiology, McMaster University, Hamilton, Canada. LA - eng GR - CAPMC/CIHR/Canada PT - Comparative Study PT - Journal Article PL - England TA - Child Care Health Dev JT - Child: care, health and development JID - 7602632 SB - IM MH - Humans MH - Infant MH - Male MH - Child, Preschool MH - Female MH - *Accelerometry/methods/instrumentation MH - Sedentary Behavior MH - *Exercise/physiology MH - Sleep MH - Algorithms MH - Reproducibility of Results MH - *Actigraphy/instrumentation/methods PMC - PMC12232370 OTO - NOTNLM OT - accelerometer OT - actigraphy OT - early years OT - nonwear OT - raw data OT - toddler COIS- The authors declare no conflicts of interest. EDAT- 2025/07/04 12:43 MHDA- 2025/07/04 12:44 PMCR- 2025/07/07 CRDT- 2025/07/04 06:43 PHST- 2025/06/18 00:00 [revised] PHST- 2024/08/31 00:00 [received] PHST- 2025/06/24 00:00 [accepted] PHST- 2025/07/04 12:44 [medline] PHST- 2025/07/04 12:43 [pubmed] PHST- 2025/07/04 06:43 [entrez] PHST- 2025/07/07 00:00 [pmc-release] AID - CCH70133 [pii] AID - 10.1111/cch.70133 [doi] PST - ppublish SO - Child Care Health Dev. 2025 Jul;51(4):e70133. doi: 10.1111/cch.70133. PMID- 40612318 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250705 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - Intergenerational chronic undernutrition pattern and determinants in Ethiopia: a multilevel and spatial analysis of EDHS data (2000-2016). PG - 1537348 LID - 10.3389/fnut.2025.1537348 [doi] LID - 1537348 AB - INTRODUCTION: Intergenerational chronic undernutrition is a condition where both mothers and children experience poor nutrition, leading to a cycle of malnutrition that affects multiple generations. In Ethiopia, chronic undernutrition is a major public health challenge, impacting the health of both mothers and children and contributing to high rates of child mortality and stunting. This study aims to explore various individual, community, and environmental factors that contribute to intergenerational chronic malnutrition, focusing on regional differences and identifying targeted interventions to break the cycle of malnutrition. METHODS: This study uses a cross-sectional design based on data from the Ethiopian Demographic and Health Surveys, conducted in 2000, 2005, 2011, and 2016, with a total of 30,667 participants. Spatial analysis and a multilevel binary logistic regression model were employed to identify geographical variations and potential risk factors for Intergenerational chronic undernutrition among mothers with children aged 0-59 months in Ethiopia. We used ArcMap to assess spatial patterns of undernutrition through Global Moran's I, identify hotspots with Getis-Ord Gi*, and apply interpolation to estimate values in unsampled areas. Variables with p-values less than 0.2 in the bivariable analysis were included in the multivariable model. Statistical significance was determined at a 5% level. All analyses were performed using STATA 17. We used the intraclass correlation coefficient (ICC) to assess cluster variance, the median odds ratio (MOR) to evaluate heterogeneity, and the proportional change in variance (PCV) to monitor variance changes across models. RESULT: From 2000 to 2016, a total of weighted 33,445 samples of mothers with children aged 0-59 months and their households were included in the analysis. The overall prevalence of intergenerational chronic undernutrition was 19.09% (95% CI: 18.68-19.52%). Hotspot areas for intergenerational chronic undernutrition were primarily in northern and northeastern Ethiopia, including Tigray, Amhara, and parts of Afar. Spatial scan analysis revealed a major cluster covering most of Amhara, Tigray, Afar, and northern Somali. Several factors were significantly associated with intragenerational chronic malnutrition. Female children (AOR = 0.93; 95% CI: 0.86-0.99), maternal education at secondary level or higher (AOR = 0.42; 95% CI: 0.32-0.54), and higher household wealth status (AOR = 0.86; 95% CI: 0.76-0.96) were negatively associated with intergenerational chronic undernutrition. In contrast older child age (AOR = 3.93; 95% CI: 3.37-4.58), use of unimproved toilet facilities (AOR = 1.26; 95% CI: 1.08-1.46) and residence in the Amhara region were positively associated with intergenerational chronic undernutrition. Moreover, children from Somali, Oromia, Harari, Gambela, Addis Ababa, and Dire Dawa regions were less likely to experience intergenerational chronic undernutrition compared to those from Tigray. CONCLUSION: This analysis identifies factors influencing intergenerational chronic undernutrition in Ethiopia, with higher prevalence in the north and northeast Ethiopia. Female children, higher maternal education level, and higher wealth status reduce risk of intergenerational chronic undernutrition, while older age, unimproved sanitation, and living in Amhara increase the risk. Participants residing in Somali, Oromia, Harari, Gambela, Addis Ababa, and Dire Dawa had lower risk compared to children residing in Tigray. Improving education, enhancing sanitation facilities, and addressing regional inequalities are crucial steps in tackling Intergenerational chronic undernutrition in Ethiopia. CI - Copyright (c) 2025 Aweke, Hagos, Abebe, Kassaw, Azmeraw, Worku, Tafere, Alemu, Alemu and Kefale. FAU - Aweke, Mekuriaw Nibret AU - Aweke MN AD - Department of Human Nutrition, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. FAU - Hagos, Asebe AU - Hagos A AD - Department of Health Systems and Policy, Institute of Public Health, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia. FAU - Abebe, Moges Tadesse AU - Abebe MT AD - Department of Pediatric and Child Health Nursing, College of Health Science, Debark University, Debark, Ethiopia. FAU - Kassaw, Amare AU - Kassaw A AD - Department of Pediatrics and Child Health Nursing, College of Medicine and Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia. FAU - Azmeraw, Molla AU - Azmeraw M AD - Department of Nursing, College of Health Science, Woldia University, Woldiya, Ethiopia. FAU - Worku, Nigusu AU - Worku N AD - Department of Health Systems and Policy, Institute of Public Health, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia. FAU - Tafere, Tesfahun Zemene AU - Tafere TZ AD - Department of Health Systems and Policy, Institute of Public Health, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia. FAU - Alemu, Mekides Engeda AU - Alemu ME AD - Department of Surgical Nursing, School of Nursing and Midwifery, College of Medicine and Health Sciences, Debrebrhan University, Debre Birhan, Ethiopia. FAU - Alemu, Amanuel Tesera AU - Alemu AT AD - University of Gondar Comprehensive Specialized Hospital, Gondar, Ethiopia. FAU - Kefale, Demewoz AU - Kefale D AD - Department of Pediatrics and Child Health Nursing, College of Medicine and Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia. LA - eng PT - Journal Article DEP - 20250619 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12222125 OTO - NOTNLM OT - EDHS OT - Ethiopian OT - intergenerational chronic undernutrition OT - malnutrition determinants OT - multilevel analysis OT - spatial analysis COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/07/04 06:27 MHDA- 2025/07/04 06:28 PMCR- 2025/06/19 CRDT- 2025/07/04 05:00 PHST- 2024/11/30 00:00 [received] PHST- 2025/05/21 00:00 [accepted] PHST- 2025/07/04 06:28 [medline] PHST- 2025/07/04 06:27 [pubmed] PHST- 2025/07/04 05:00 [entrez] PHST- 2025/06/19 00:00 [pmc-release] AID - 10.3389/fnut.2025.1537348 [doi] PST - epublish SO - Front Nutr. 2025 Jun 19;12:1537348. doi: 10.3389/fnut.2025.1537348. eCollection 2025. PMID- 40612175 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250705 IS - 3050-2225 (Electronic) IS - 3050-2225 (Linking) VI - 12 DP - 2025 Jan-Dec TI - The Behavior Rating Inventory of Executive Function-Preschool Version in Nepali Children With Poor Growth in Infancy. PG - 30502225251338633 LID - 10.1177/30502225251338633 [doi] LID - 30502225251338633 AB - OBJECTIVES: To describe psychometric properties of the Behavior Rating Inventory of Executive Function-Preschool (BRIEF-P) and its discriminatory ability for risk groups for executive dysfunction (low birth weight (LBW), stunting and low maternal education) among children with poor growth in infancy. INTRODUCTION: BRIEF-P is widely used to measure executive functions, but knowledge on its psychometric properties in low-and-middle-income countries is limited. METHOD: The sample consisted of 529 parents of children (30-35 months). BRIEF-P was subject to confirmatory factor analysis, and internal consistency by alpha calculations and inter-correlations. RESULTS: A good fit for a bifactor-model with 5 subscales and a general factor. BRIEF-P subscales were higher when mothers had low versus high education. Children born with LBW compared to normal birth weight had poorer Shift and Flexibility scores. CONCLUSION: BRIEF-P is feasible and reliable tool to measure executive functions in Nepali children and is associated with key risk factors for executive dysfunction. CI - (c) The Author(s) 2025. FAU - Sintakala, Roshan AU - Sintakala R AUID- ORCID: 0009-0000-6693-9895 AD - Department of Pediatrics, Child Health Research Project, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal. FAU - Ranjitkar, Suman AU - Ranjitkar S AD - Department of Pediatrics, Child Health Research Project, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal. FAU - Chandyo, Ram K AU - Chandyo RK AD - Department of Community Medicine, Kathmandu Medical College, Nepal. FAU - Kvestad, Ingrid AU - Kvestad I AD - Regional Centre for Child and Youth Mental Health and Child Welfare, NORCE Norwegian Research Centre, Bergen, Norway. AD - Innlandet Hospital Trust, Lillehammer, Norway. FAU - Ulak, Manjeswori AU - Ulak M AD - Department of Pediatrics, Child Health Research Project, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal. AD - Center for Intervention Science in Maternal and Child Health, Department of Global health and primary care, Centre for International Health, University of Bergen, Bergen, Norway. FAU - Silpakar, Jaya S AU - Silpakar JS AD - Department of Pediatrics, Child Health Research Project, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal. FAU - Shrestha, Merina AU - Shrestha M AD - Department of Pediatrics, Child Health Research Project, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal. FAU - Shrestha, Laxman AU - Shrestha L AD - Department of Pediatrics, Child Health Research Project, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal. FAU - Hysing, Mari AU - Hysing M AUID- ORCID: 0000-0001-5303-8879 AD - Department of Psychosocial Science University of Bergen, Norway. LA - eng PT - Journal Article DEP - 20250526 PL - United States TA - Sage Open Pediatr JT - Sage open pediatrics JID - 9919052035406676 PMC - PMC12220922 OTO - NOTNLM OT - BRIEF-P OT - confirmatory factor analysis OT - executive functions OT - preschool OT - psychometrics COIS- The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/07/04 06:27 MHDA- 2025/07/04 06:28 PMCR- 2025/05/26 CRDT- 2025/07/04 04:58 PHST- 2024/09/12 00:00 [received] PHST- 2025/03/01 00:00 [revised] PHST- 2025/04/13 00:00 [accepted] PHST- 2025/07/04 06:28 [medline] PHST- 2025/07/04 06:27 [pubmed] PHST- 2025/07/04 04:58 [entrez] PHST- 2025/05/26 00:00 [pmc-release] AID - 10.1177_30502225251338633 [pii] AID - 10.1177/30502225251338633 [doi] PST - epublish SO - Sage Open Pediatr. 2025 May 26;12:30502225251338633. doi: 10.1177/30502225251338633. eCollection 2025 Jan-Dec. PMID- 40612048 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250705 IS - 2475-2991 (Electronic) IS - 2475-2991 (Linking) VI - 9 IP - 7 DP - 2025 Jul TI - Determinants of Caregivers' Ability to Accurately Detect Acute Malnutrition Using Color-Coded Mid-Upper Arm Circumference Tape and Pitting Edema. PG - 107477 LID - 10.1016/j.cdnut.2025.107477 [doi] LID - 107477 AB - BACKGROUND: In Malawi, inadequate community health workers are delaying admission of acute malnutrition cases into therapeutic programs. Training caregivers to screen their children for early identification of acute malnutrition has been shown to improve early admissions, prevent serious complications, and save lives. However, there are knowledge gaps regarding the determinants of caregivers to accurately screen for acute malnutrition. OBJECTIVES: To identify determinants of accuracy in detecting acute malnutrition using color-coded mid-upper arm circumference (MUAC) tape and pitting edema among caregivers. METHODS: This was a cross-sectional study taken as a baseline for a larger non-random pragmatic interventional study. Using a cascade model, community health workers (health surveillance assistants, n = 148) from 2 southern districts of Nsanje and Phalombe in Malawi, trained 12,057 caregivers of children aged 6 to 54 months in nutritional screening using color-coded MUAC tapes and pitting edema. Pretested structured questionnaires were used in face-to-face interviews with the caregivers to collect data on their age, marital status, education, district, occupation, and age of the child, which were predictor variables. Caregivers' accuracy was the response variable. Binary logistic regression was used to assess the effect of each predictor variable on accuracy of caregivers. RESULTS: Compared to caregivers who were farmers (86.2%), those who were formally employed (1.8%) were nearly 70% less likely to accurately determine acute malnutrition [adjusted odds ratio (AOR): 0.30; 95% confidence interval (CI): 0.12, 0.75] than farmers. Caregivers from Phalombe district were nearly 5 times more likely to be accurate than caregivers from Nsanje district (AOR: 4.93; 95% CI: 3.31, 7.35). Caregivers were twice and thrice more likely to accurately screen children aged 31-42 mo (AOR: 2.44; 95% CI: 1.43, 4.17) and 43-54 mo (AOR: 2.83; 95% CI: 1.45, 5.54), respectively, than children aged 6-11 mo. CONCLUSIONS: The outcome of training caregivers to use color-coded MUAC tapes and pitting edema to screen for acute malnutrition is likely to be sensitive to several factors including residence, occupation of the caregivers, and age of the children. More data and further studies are required to validate the present results. CI - (c) 2025 The Author(s). FAU - Singano, Benson C AU - Singano BC AD - Department of Human Nutrition and Health, Lilongwe University of Agriculture and Natural Resources, Lilongwe, Malawi. AD - Screening and Referral by Caregivers Project, Lilongwe University of Agriculture and Natural Resources, Lilongwe, Malawi. FAU - Tchongwe, Collina A AU - Tchongwe CA AD - Department of Human Nutrition and Health, Lilongwe University of Agriculture and Natural Resources, Lilongwe, Malawi. AD - Screening and Referral by Caregivers Project, Lilongwe University of Agriculture and Natural Resources, Lilongwe, Malawi. FAU - Geresomo, Numeri C AU - Geresomo NC AD - Department of Human Nutrition and Health, Lilongwe University of Agriculture and Natural Resources, Lilongwe, Malawi. FAU - Ng'ong'ola-Manani, Tinna AU - Ng'ong'ola-Manani T AD - Department of Food Science and Technology, Lilongwe University of Agriculture and Natural Resources, Lilongwe, Malawi. FAU - Chikakuda, Aaron T AU - Chikakuda AT AD - Department of Human Nutrition and Health, Lilongwe University of Agriculture and Natural Resources, Lilongwe, Malawi. FAU - Ngwira, Alfred AU - Ngwira A AD - Department of Basic Sciences, Lilongwe University of Agriculture and Natural Resources, Lilongwe, Malawi. FAU - Mwase, Stanley AU - Mwase S AD - Nutrition section, United Nations Children's Fund, Lilongwe, Malawi. FAU - Mawala, Elsie AU - Mawala E AD - Nutrition section, United Nations Children's Fund, Lilongwe, Malawi. FAU - Kazembe, Benson AU - Kazembe B AD - Nutrition section, United Nations Children's Fund, Lilongwe, Malawi. FAU - Budalla, Emma AU - Budalla E AD - Screening and Referral by Caregivers Project, Lilongwe University of Agriculture and Natural Resources, Lilongwe, Malawi. FAU - Kalimbira, Alexander A AU - Kalimbira AA AD - Department of Human Nutrition and Health, Lilongwe University of Agriculture and Natural Resources, Lilongwe, Malawi. AD - Screening and Referral by Caregivers Project, Lilongwe University of Agriculture and Natural Resources, Lilongwe, Malawi. LA - eng PT - Journal Article DEP - 20250528 PL - United States TA - Curr Dev Nutr JT - Current developments in nutrition JID - 101717957 PMC - PMC12221631 OTO - NOTNLM OT - MUAC tape OT - acute malnutrition OT - caregivers OT - children OT - nutritional screening COIS- AAK reports financial support was provided by UNICEF. EM reports a relationship with UNICEF that includes: employment. SM reports a relationship with UNICEF that includes: employment. BK reports a relationship with UNICEF that includes: employment. UNICEF Malawi office provided funding for the research. The funding bodies had no involvement in the research design, data gathering and analysis, publication decisions, or manuscript preparation. The authors bear sole responsibility for the content, which may not necessarily reflect UNICEF's official stance. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article. EDAT- 2025/07/04 06:26 MHDA- 2025/07/04 06:27 PMCR- 2025/05/28 CRDT- 2025/07/04 04:57 PHST- 2025/02/06 00:00 [received] PHST- 2025/05/07 00:00 [revised] PHST- 2025/05/14 00:00 [accepted] PHST- 2025/07/04 06:27 [medline] PHST- 2025/07/04 06:26 [pubmed] PHST- 2025/07/04 04:57 [entrez] PHST- 2025/05/28 00:00 [pmc-release] AID - S2475-2991(25)02938-5 [pii] AID - 107477 [pii] AID - 10.1016/j.cdnut.2025.107477 [doi] PST - epublish SO - Curr Dev Nutr. 2025 May 28;9(7):107477. doi: 10.1016/j.cdnut.2025.107477. eCollection 2025 Jul. PMID- 40611195 OWN - NLM STAT- MEDLINE DCOM- 20250704 LR - 20260328 IS - 2072-1315 (Electronic) IS - 1606-0997 (Print) IS - 1606-0997 (Linking) VI - 44 IP - 1 DP - 2025 Jul 3 TI - Exploring the determinants of thyroid disorders in high-altitude western Himalaya: a geospatial and epidemiological study. PG - 236 LID - 10.1186/s41043-025-00844-z [doi] LID - 236 AB - BACKGROUND: The impact of high-altitude on thyroid function is an emerging field of research. Apart from environmental stress through hypoxia and iodine deficiency, socioeconomic, demographic, and dietary factors may play a role, particularly for those with pre-existing thyroid conditions. This study explored the prevalence and determinants of thyroid disorders (TDs) among the Gujjar and Bakarwal tribes in the high-altitude western Himalayas. METHODS: We assessed potential risk factors, with focus on environment, socioeconomy and lifestyle based on household survey data. A stratified random sampling method was employed to select a representative sample (n = 816) from 50 villages. The binary logistic regression model (BLRM) was used to identify risk factors for TDs, with model fit evaluated using pseudo-R(2) and Hosmer-Lemeshow tests. Geographic information systems were utilized to map the spatial distribution of thyroid disorder prevalence, and the model's predictive accuracy was validated using receiver operating characteristic (ROC). RESULTS: The TD prevalence was 18.6%. Higher altitude significantly increased likelihood of this disease (adjusted odds ratio [AOR]: 6.80, 95% CI: 1.62-28.50, p = 0.009). The Bakarwals had lower odds compared to the Gujjars (AOR: 0.19, 95% CI: 0.05-0.67, p = 0.010). Risk factors included living in extended families, smoking, other tobacco uses, traditional housing and specific dietary patterns. Protective factors included modern housing, higher education and iodized salt consumption. High-risk areas were concentrated to middle and high-altitude zones. The model demonstrated excellent fit (Hosmer-Lemeshow, p = 0.967, Nagelkerke R(2) = 90.5) and high predictive accuracy (ROC-AUC = 0.99). CONCLUSION: Thyroid disorders in this high-altitude population are influenced by a combination of environmental, demographic, and lifestyle factors. This study underscores the need for tailored public health interventions that address these determinants and reduce health disparities in geographically challenging regions. Future research should explore these findings in other high-altitude contexts to guide global thyroid health strategies. CI - (c) 2025. The Author(s). FAU - Ahmed, Arshad AU - Ahmed A AD - Department of Geography, School of Basic Sciences, Central University of Haryana, Mahendergarh, India. FAU - Kheraj AU - Kheraj AD - Department of Geography, School of Basic Sciences, Central University of Haryana, Mahendergarh, India. kheraj.jnu@gmail.com. FAU - Mohammadi, Alireza AU - Mohammadi A AD - Department of Geography and Urban Planning, Faculty of Social Sciences, University of Mohaghegh Ardabili, Ardabil, Iran. alirezamohammadi20142014@gmail.com. FAU - Bergquist, Robert AU - Bergquist R AD - Ingerod, 454 94, Brastad, Sweden. AD - Formerly UNICEF/UNDP/World Bank/WHO Special Programme for (Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland. LA - eng GR - 001/WHO_/World Health Organization/International PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250703 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 RN - 9679TC07X4 (Iodine) SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - *Altitude MH - Diet MH - India/epidemiology MH - Iodine/deficiency MH - Life Style MH - Logistic Models MH - Prevalence MH - Risk Factors MH - Socioeconomic Factors MH - *Thyroid Diseases/epidemiology/etiology PMC - PMC12231670 OTO - NOTNLM OT - Binary Logistic Regression OT - Geospatial analysis OT - High-altitude OT - Public health interventions OT - Risk factors OT - Thyroid disorders COIS- Declarations. Ethics approval and consent to participate: This study was carried out at an institution lacking an ethics committee, so it did not undergo a formal ethics review. Informed consent was obtained from all participants according to standard practices. Additionally, the study involved participants under the age of 18, and informed consent was obtained from their parents or legal guardians as per ethical guidelines. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/07/04 00:27 MHDA- 2025/07/04 06:27 PMCR- 2025/07/03 CRDT- 2025/07/03 23:53 PHST- 2024/11/21 00:00 [received] PHST- 2025/03/21 00:00 [accepted] PHST- 2025/07/04 06:27 [medline] PHST- 2025/07/04 00:27 [pubmed] PHST- 2025/07/03 23:53 [entrez] PHST- 2025/07/03 00:00 [pmc-release] AID - 10.1186/s41043-025-00844-z [pii] AID - 844 [pii] AID - 10.1186/s41043-025-00844-z [doi] PST - epublish SO - J Health Popul Nutr. 2025 Jul 3;44(1):236. doi: 10.1186/s41043-025-00844-z. PMID- 40611141 OWN - NLM STAT- MEDLINE DCOM- 20250704 LR - 20250706 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Jul 3 TI - A participatory framework for identifying and ranking multidimensional solutions to nutritional behavior issues in female school students: a stakeholder-based mixed-methods study. PG - 2344 LID - 10.1186/s12889-025-23575-6 [doi] LID - 2344 AB - BACKGROUND: Broad multisectoral collaboration among families, communities, schools, health services, and policymakers is essential for improving nutritional behaviors. Despite the increasing prevalence of poor dietary habits among adolescent girls, existing interventions often fail to address the complex social, cultural, and environmental determinants of nutritional behavior. This study aimed to develop a proposed solution to improve the nutritional behaviors of female school students aged 13-17 years in Khuzestan, Iran. METHODS: This study employed a mixed-methodology approach, integrating qualitative exploration and stakeholder-driven prioritization. Phase 1 utilized directed qualitative inquiry with 17 school students to identify adolescent dietary challenges, while Phase 2 applied the Nominal Group Technique (NGT) and Analytic Hierarchy Process (AHP) to prioritize solutions through expert consensus and multicriteria evaluation. The AHP framework, which is supported by Expert Choice software, ensures rigorous weight assignment (CR < 0.1) as validated by independent expert review. RESULTS: In Phase 1, directed content analysis of 17 student interviews yielded six overarching themes (e.g., "Self-Monitoring and Goal Setting," "Social Environmental Influences") and 15 subthemes, from which 121 candidate solutions were generated. During Phase 2, nine panelists (five nutrition experts and four stakeholders) applied the NGT: 74.4% (90/121) of the solutions met the >/= 4.0 mean ranking threshold (on a 5-point scale), while 25.6% (31/121) were eliminated. The 90 retained solutions were then scored via the AHP across five criteria-effectiveness, feasibility, cost efficiency, sustainability, and cultural acceptability. Cultural acceptability received the highest weight (35.7%), followed by sustainability (18.1%), cost efficiency (20.2%), effectiveness (16.8%), and feasibility (12.1%). The consistency was excellent (CR = 0.003), and sensitivity analyses confirmed the stability of the rank order under +/- 15% weight variation. CONCLUSION: This stakeholder-driven framework highlighted balanced diet education during puberty, parental education sessions, and school nutrition campaigns as top-priority interventions, demonstrating excellent consistency (CR = 0.003). Future studies should pilot and rigorously evaluate these interventions in real-world school settings, assess their long-term impacts on dietary behaviors and health outcomes, analyze cost-effectiveness, and explore digital delivery platforms to increase adolescent engagement. CI - (c) 2025. The Author(s). FAU - Mehrjoyan, Nasrin AU - Mehrjoyan N AUID- ORCID: 0000-0002-8452-4375 AD - Department of Health Education & Health Promotion, Faculty of Medical Sciences, Tarbiat Modares University, P.O. Box: 14115-111, Tehran Jalal AleAhmad Nasr, Tehran, Iran. FAU - Zarei, Fatemeh AU - Zarei F AUID- ORCID: 0000-0003-1561-3646 AD - Department of Health Education & Health Promotion, Faculty of Medical Sciences, Tarbiat Modares University, P.O. Box: 14115-111, Tehran Jalal AleAhmad Nasr, Tehran, Iran. f.zarei@modares.ac.ir. FAU - Ghofranipour, Fazlollah AU - Ghofranipour F AUID- ORCID: 0000-0002-2338-230X AD - Department of Health Education & Health Promotion, Faculty of Medical Sciences, Tarbiat Modares University, P.O. Box: 14115-111, Tehran Jalal AleAhmad Nasr, Tehran, Iran. FAU - Ahmadi, Fazlollah AU - Ahmadi F AUID- ORCID: 0000-0002-1961-7735 AD - Department of Nursing, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. LA - eng PT - Journal Article DEP - 20250703 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - Adolescent MH - Iran MH - Qualitative Research MH - *Students/psychology/statistics & numerical data MH - *Feeding Behavior/psychology MH - *Stakeholder Participation MH - *Health Promotion/methods MH - Interviews as Topic PMC - PMC12225208 OTO - NOTNLM OT - Adolescent Nutrition OT - Analytic Hierarchy Process OT - Female School Students OT - Mixed-Methods Study OT - Nominal Group Technique OT - Stakeholder Engagement COIS- Declarations. Ethics approval and consent to participate: All methods were carried out following relevant guidelines and regulations (Helsinki Declaration of Ethical Principles for Medical Research and Ethical Research Guidelines Involving Children (ERIC) guidelines). Ethical approval was obtained from the Ethics Committee of the faculty of medical sciences at Tarbiat Modares University (IR.MODARES.REC.1402.247). Informed consent to participate was obtained from all of the participants in the study. Written informed consent to participate was obtained from the parents or legal guardians of any participant. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/07/04 00:27 MHDA- 2025/07/04 06:26 PMCR- 2025/07/03 CRDT- 2025/07/03 23:50 PHST- 2025/02/22 00:00 [received] PHST- 2025/06/12 00:00 [accepted] PHST- 2025/07/04 06:26 [medline] PHST- 2025/07/04 00:27 [pubmed] PHST- 2025/07/03 23:50 [entrez] PHST- 2025/07/03 00:00 [pmc-release] AID - 10.1186/s12889-025-23575-6 [pii] AID - 23575 [pii] AID - 10.1186/s12889-025-23575-6 [doi] PST - epublish SO - BMC Public Health. 2025 Jul 3;25(1):2344. doi: 10.1186/s12889-025-23575-6. PMID- 40611112 OWN - NLM STAT- MEDLINE DCOM- 20250704 LR - 20250708 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Jul 3 TI - Redevelopment and examination of the psychometric properties of school physical activity environment in Chinese. PG - 2348 LID - 10.1186/s12889-025-23571-w [doi] LID - 2348 AB - BACKGROUND: This study adapted the Questionnaire Assessing School Physical Activity Environment (Q-SPACE) into Chinese and evaluated its psychometric properties. METHODS: A total of 253 primary school and 267 secondary school students completed the modified Q-SPACE-Chi twice, with a 2-week interval, between November 2022 and March 2023. A confirmatory factor analysis and the assessment of measurement invariance supported the efficiency of the three-factor Q-SPACE-Chi (i.e., physical environment, social environment, and school policy) across various groups. RESULTS: The results confirmed the factorial validity of the three-factor modified A-SPACE-Chi, with all items demonstrating significant loadings in the physical environment, special environment, and social policy dimensions. The predictive validity results revealed significant associations between student's perceived school physical activity environment and the physical activity level. Moreover, the test-retest reliability and internal consistency of the adapted questionnaire were moderately favorable. CONCLUSION: This modified Q-SPACE-Chi, with element of school policy therefore presents an additional valuable tool for researchers or practitioners aiming to evaluate how Chinese students perceive the school physical activity environments within their schools while the measurement properties of Q-SPACE-Chi was invariant among primary and secondary students. CI - (c) 2025. The Author(s). FAU - Leung, Ka-Man AU - Leung KM AUID- ORCID: 0000-0003-1409-109X AD - Department of Health and Physical Education, The Education University of Hong Kong, 10 Lo Ping Road, Tai Po, New Territories, Hong Kong, China. leungkaman@eduhk.hk. LA - eng GR - RG 73/2019-2020R/The Start-up Research Grant, Education University of Hong Kong/ PT - Journal Article DEP - 20250703 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - Chinese people SB - IM MH - Humans MH - Psychometrics MH - *Exercise/psychology MH - *Schools MH - Female MH - Male MH - China MH - Surveys and Questionnaires/standards MH - Adolescent MH - Reproducibility of Results MH - *Students/psychology/statistics & numerical data MH - Child MH - *Social Environment MH - Factor Analysis, Statistical MH - East Asian People PMC - PMC12225071 OTO - NOTNLM OT - Environments OT - Exercise OT - Measurement OT - School OT - Student COIS- Declarations. Ethics approval and consent to participate: The purpose and details of the study were explained to all participants at the beginning of data collection. After obtaining informed consent from all participants, he or she completed a questionnaire during the site visit. Permission for human research was obtained from the University Institutional Review Board (Reference No. 2019-2020-0303) prior to the commencement of the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. ORCID: 0000-0003-1409-109X. EDAT- 2025/07/04 00:28 MHDA- 2025/07/04 06:27 PMCR- 2025/07/03 CRDT- 2025/07/03 23:49 PHST- 2024/01/05 00:00 [received] PHST- 2025/06/11 00:00 [accepted] PHST- 2025/07/04 06:27 [medline] PHST- 2025/07/04 00:28 [pubmed] PHST- 2025/07/03 23:49 [entrez] PHST- 2025/07/03 00:00 [pmc-release] AID - 10.1186/s12889-025-23571-w [pii] AID - 23571 [pii] AID - 10.1186/s12889-025-23571-w [doi] PST - epublish SO - BMC Public Health. 2025 Jul 3;25(1):2348. doi: 10.1186/s12889-025-23571-w. PMID- 40607191 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250704 IS - 2673-253X (Electronic) IS - 2673-253X (Linking) VI - 7 DP - 2025 TI - Beyond the interface: benchmarking pediatric mobile health applications for monitoring child growth using the Mobile App Rating Scale. PG - 1621293 LID - 10.3389/fdgth.2025.1621293 [doi] LID - 1621293 AB - INTRODUCTION: As mHealth applications become increasingly adopted in Indonesia, it is crucial to assess their quality and usability for parents and healthcare professionals. AIM: This study evaluated the quality of pediatric-related mobile health (mHealth) applications available in Indonesia, focusing on their ability to support child growth monitoring and provide educational resources for parents and caregivers. METHODOLOGY: This is a cross-sectional study. From December 1, 2024, and January 31, 2025 we conducted systematic search for pediatric mHealth applications in Indonesian Google Play Store and Apple App Store using predetermined keywords. Inclusion criteria required the applications to be available in Bahasa Indonesia, focus on child health, and include growth tracking or stunting prevention features. We excluded applications that were not functioning during the testing period. Quality assessment was conducted by five healthcare professionals using the Mobile App Rating Scale (MARS). MARS assessed applications from multiple domains, including engagement, functionality, aesthetics, and information quality. Inter-rater reliability was ensured using the Intraclass Correlation Coefficient (ICC). The results were analyzed using descriptive statistics, Pearson's correlation, and T-tests. A p-value of <0.05 is considered to be statistically significant. FINDINGS: Nine applications were included in this study. Seven of the applications (77.78%) focused on tracking child growth and development and providing educational content. Less than half of the apps had built-in community features that enabled social support (n = 4, 44.44%) and features for feedback mechanisms & personalized guidance (n = 3, 33.33%) respectively. The majority were developed by commercial companies (n = 7, 77.78%). Quality assessment found significant variability across the apps, with high functionality and aesthetics scores but more variability in the domains of app engagement, quality of information, and subjective quality or perceived value. CONCLUSION: This research underscored the need for the development of higher-quality, evidence-based mHealth apps for pediatric care in Indonesia, particularly in improving user engagement, feedback mechanisms and accessibility. CI - (c) 2025 Irawan, Alristina, Laili, Amalia, Muharram, Miranda, Dobrossy and Girasek. FAU - Irawan, Anggi Septia AU - Irawan AS AD - Institute of Behavioral Sciences, Semmelweis University, Budapest, Hungary. FAU - Alristina, Arie Dwi AU - Alristina AD AD - Health Sciences Division, Doctoral College, Semmelweis University, Budapest, Hungary. AD - Sekolah Tinggi Ilmu Kesehatan Hang Tuah, Surabaya, Indonesia. FAU - Laili, Rizky Dzariyani AU - Laili RD AD - Sekolah Tinggi Ilmu Kesehatan Hang Tuah, Surabaya, Indonesia. FAU - Amalia, Nuke AU - Amalia N AD - Safety and Health Engineering Study Program, Politeknik Perkapalan Negeri, Surabaya, Indonesia. FAU - Muharram, Arief Purnama AU - Muharram AP AD - HealthAI Indonesia, Jakarta, Indonesia. FAU - Miranda, Adriana Viola AU - Miranda AV AD - 1000 Days Fund, Denpasar, Indonesia. FAU - Dobrossy, Bence AU - Dobrossy B AD - Institute of Behavioral Sciences, Semmelweis University, Budapest, Hungary. FAU - Girasek, Edmond AU - Girasek E AD - Institute of Behavioral Sciences, Semmelweis University, Budapest, Hungary. LA - eng PT - Journal Article DEP - 20250618 PL - Switzerland TA - Front Digit Health JT - Frontiers in digital health JID - 101771889 PMC - PMC12213656 OTO - NOTNLM OT - assessment OT - digital health OT - e-health OT - pediatric care OT - stunting prevention OT - user experience (UX) OT - user interface (UI) COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/07/03 17:33 MHDA- 2025/07/03 17:34 PMCR- 2025/06/18 CRDT- 2025/07/03 06:02 PHST- 2025/05/07 00:00 [received] PHST- 2025/06/03 00:00 [accepted] PHST- 2025/07/03 17:34 [medline] PHST- 2025/07/03 17:33 [pubmed] PHST- 2025/07/03 06:02 [entrez] PHST- 2025/06/18 00:00 [pmc-release] AID - 10.3389/fdgth.2025.1621293 [doi] PST - epublish SO - Front Digit Health. 2025 Jun 18;7:1621293. doi: 10.3389/fdgth.2025.1621293. eCollection 2025. PMID- 40606898 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250704 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 16 DP - 2025 TI - Reliability and validity of the Addiction-Like eating behavior scale (AEBS) in a Peruvian adolescent population. PG - 1490893 LID - 10.3389/fpsyg.2025.1490893 [doi] LID - 1490893 AB - BACKGROUND: Understanding eating behaviors in Latin American contexts is crucial, given the current epidemic of obesity among adolescents in this region. OBJECTIVE: The study aimed to analyze the psychometric properties of the Addiction-Like Eating Behavior Scale (AEBS) in adolescents from Peru. METHODOLOGY: The study was psychometric in nature, conducted with a sample of 1,249 adolescents from coastal (Chimbote, n = 841) and jungle (Tarapoto, n = 408) cities in Peru. An exploratory factor analysis (EFA) was performed, and a scree plot was used to determine the factors. Additionally, a confirmatory factor analysis (CFA) was conducted to evaluate the goodness-of-fit indices used for structural validity, and the reliability of the Peruvian version of the AEBS was determined using McDonald's Omega. RESULTS: The EFA reported the presence of three factors (KMO = 0.80 and p < 0.000). Furthermore, the CFA reported adequate fit indices (chi(2) = 881.401; CFI = 0.957; TLI = 0.946; RMSEA = 0.074; and SRMR = 0.066) confirming the structure. The reliability was acceptable, with omega > 0.65 for all factors. CONCLUSION: The adapted version of the AEBS is valid and reliable for use with Peruvian adolescents. CI - Copyright (c) 2025 Figueroa-Quinones, Heredia, Cjuno, Yupanqui-Lorenzo, Acharte-Champi and Fernandini-Valenzuela. FAU - Figueroa-Quinones, Joel AU - Figueroa-Quinones J AD - Universidad Autonoma de Ica, Escuela de Psicologia, Ica, Peru. FAU - Heredia, Nelly T Condor AU - Heredia NTC AD - Universidad Cesar Vallejo, Escuela de Medicina, Piura, Peru. FAU - Cjuno, Julio AU - Cjuno J AD - Universidad Cesar Vallejo, Escuela de Medicina, Piura, Peru. FAU - Yupanqui-Lorenzo, Daniel E AU - Yupanqui-Lorenzo DE AD - Centro de Investigacion e-Health, Universidad de Ciencias y Humanidades, Lima, Peru. FAU - Acharte-Champi, Walter Jesus AU - Acharte-Champi WJ AD - Universidad Autonoma de Ica, Escuela de Psicologia, Ica, Peru. FAU - Fernandini-Valenzuela, Khristel AU - Fernandini-Valenzuela K AD - Universidad Autonoma de Ica, Escuela de Psicologia, Ica, Peru. LA - eng PT - Journal Article DEP - 20250618 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC12217219 OTO - NOTNLM OT - adolescents OT - eating behavior OT - food addiction OT - reliability OT - validation COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/07/03 06:28 MHDA- 2025/07/03 06:29 PMCR- 2025/06/18 CRDT- 2025/07/03 05:57 PHST- 2024/09/03 00:00 [received] PHST- 2025/05/22 00:00 [accepted] PHST- 2025/07/03 06:29 [medline] PHST- 2025/07/03 06:28 [pubmed] PHST- 2025/07/03 05:57 [entrez] PHST- 2025/06/18 00:00 [pmc-release] AID - 10.3389/fpsyg.2025.1490893 [doi] PST - epublish SO - Front Psychol. 2025 Jun 18;16:1490893. doi: 10.3389/fpsyg.2025.1490893. eCollection 2025. PMID- 40606081 OWN - NLM STAT- MEDLINE DCOM- 20250703 LR - 20250710 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Improving nutritional status and health outcomes in school-going adolescents: a randomized controlled trial of nutrition and WASH education interventions in Gojra, Pakistan. PG - 1440634 LID - 10.3389/fpubh.2025.1440634 [doi] LID - 1440634 AB - The presence of both undernutrition and over-nutrition within a population is termed the double burden of malnutrition. Among school-going adolescents, prevalent micronutrient deficiencies are iron, iodine, vitamin A, and zinc. This study examined the effect of a school-based nutrition and WASH (Water, Sanitation and Hygiene) education on low body mass index (BMI;<18.5 kg/m(2)) and malnutrition symptoms among adolescents in Gojra. A randomized controlled trial was conducted involving 603 participants from grades 6 to 8, with 321 in the intervention group and 282 in the control group. Pre- and post-intervention assessments included validated questionnaire. Blood tests, anthropometric measurements, BMI evaluations and clinical assessments were performed to identify biochemical markers and cases of malnutrition. Following the intervention, a slight decrease in average BMI was observed (from 16.7 to 16.2 in boys and 18.5 to 17.6 in girls). Stunting increased in the control group but remained stable among intervention group of boys and showed only a slight rise in girls. Clinical improvement was noted in indicators such as hair, nails, eyes, and teeth, although biomarkers remained largely unchanged. In conclusion, the school-based intervention had a positive effect on clinical nutritional indicators and helped prevent further deterioration of nutritional status. While BMI and biomarkers showed minimal changes, the visible health improvements highlight the potential of integrated school health program to address the dual burden of malnutrition in adolescents. CI - Copyright (c) 2025 Perveen, Karmaliani, Mistry and Barolia. FAU - Perveen, Shagufta AU - Perveen S AD - School of Nursing and Midwifery, Aga Khan University, Karachi, Pakistan. FAU - Karmaliani, Rozina AU - Karmaliani R AD - School of Nursing and Midwifery, Aga Khan University, Karachi, Pakistan. FAU - Mistry, Rozina Farhad AU - Mistry RF AD - School of Nursing and Midwifery, Aga Khan University, Karachi, Pakistan. FAU - Barolia, Rubina AU - Barolia R AD - School of Nursing and Midwifery, Aga Khan University, Karachi, Pakistan. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20250618 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Male MH - Female MH - Adolescent MH - *Nutritional Status MH - Pakistan/epidemiology MH - *Malnutrition/prevention & control/epidemiology MH - Body Mass Index MH - *Hygiene/education MH - *Sanitation MH - *Health Education/methods MH - *School Health Services/organization & administration MH - Schools MH - Students/statistics & numerical data MH - Surveys and Questionnaires PMC - PMC12213414 OTO - NOTNLM OT - adolescents OT - biomarkers OT - body mass index OT - clinical assessment OT - nutrition OT - schools COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationship that could be constructed as a potential conflict of interest. EDAT- 2025/07/03 06:27 MHDA- 2025/07/03 12:32 PMCR- 2025/06/18 CRDT- 2025/07/03 05:47 PHST- 2024/05/29 00:00 [received] PHST- 2025/05/16 00:00 [accepted] PHST- 2025/07/03 12:32 [medline] PHST- 2025/07/03 06:27 [pubmed] PHST- 2025/07/03 05:47 [entrez] PHST- 2025/06/18 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1440634 [doi] PST - epublish SO - Front Public Health. 2025 Jun 18;13:1440634. doi: 10.3389/fpubh.2025.1440634. eCollection 2025. PMID- 40605237 OWN - NLM STAT- MEDLINE DCOM- 20260615 LR - 20260813 IS - 2047-2927 (Electronic) IS - 2047-2919 (Print) IS - 2047-2919 (Linking) VI - 14 IP - 5 DP - 2026 Jul TI - Maternal, childhood and adolescent influences on Leydig cell functional capacity and circulating INSL3 concentration in young adults: Importance of childhood infections and body mass index. PG - 1172-1182 LID - 10.1111/andr.70091 [doi] AB - BACKGROUND: The constitutive Leydig cell hormone insulin-like peptide 3 (INSL3) is considered a good estimate of the adult Leydig cell functional capacity and appears to remain relatively consistent throughout adult male life, only gradually declining into old age. Importantly, in younger men it appears to predict hypogonadism and hence later health and morbidity. OBJECTIVES: Here, we have used the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort of boys and young men to assess those factors during pregnancy, infancy, childhood, and adolescence, when the adult-type Leydig cell population is being established, which by association might influence the final circulating INSL3 concentration in young adulthood. METHODS: A wide range of clinical, anthropometric and lifestyle parameters were assessed from up to 2000 boys and young men based on direct medical measurement and/or by targeted questionnaires. Scalar variables used bivariate correlation analysis, whereas comparative statistics, such as t-tests, were applied to categorical variables. RESULTS: Maternal parameters, such as maternal smoking, gestational age, or being small for gestational age (SGA) appeared to have no association with adult INSL3 levels. Of all the parameters assessed, those with greatest impact on young adult Leydig cell status appeared to be childhood and adolescent body mass index (BMI) and early childhood infectious disease. Particularly, chickenpox in infancy had a marked and significant negative association with INSL3 (reduced by 10%-14%) at both 17 and 24 years. Being overweight (> 85th percentile) at 13 years was associated with a 20% reduction in young adult INSL3. In contrast, childhood and adolescent inflammatory factors and cigarette exposure appeared to have no long-lasting impact on adult Leydig cell status. LIMITATIONS: This retrospective cohort study is limited by relatively small numbers and by its correlative analysis. The hypotheses generated will need to be validated in more extensive, in-depth studies. LAY SUMMARY: The testis hormone INSL3 is considered a good estimate of the gonadal capacity to make testosterone. It is relatively constant throughout adult male life, only gradually declining into old age. Importantly, in younger men reduced INSL3 appears to predict hypogonadism and hence later health and morbidity. Whilst showing low within-individual variation, between individuals INSL3 can vary more than 10- up to 100-fold. The source of this variance is unknown but is believed to have its origin during childhood and adolescence. Analysis of data from the ALSPAC cohort implies that of various parameters assessed, only childhood and adolescent BMI as well as early infectious disease, in particular chickenpox, have any influence on young adult INSL3 concentration, respectively reducing circulating levels each by 10%-20%. More research is needed to understand the mechanisms how these factors influence testis function, what can be done as mitigation, and what other factors may be involved. CI - (c) 2025 The Author(s). Andrology published by John Wiley & Sons Ltd on behalf of American Society of Andrology and European Academy of Andrology. FAU - Ivell, Richard AU - Ivell R AD - School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough, UK. FAU - Tulumcu, Bilal AU - Tulumcu B AD - School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough, UK. FAU - Alhujaili, Waleed AU - Alhujaili W AD - School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough, UK. AD - Present address: Department of Biology, College of Science, Taibah University, Medina, Saudi Arabia. FAU - Anand-Ivell, Ravinder AU - Anand-Ivell R AD - School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough, UK. LA - eng GR - 217065/Z/19/Z/The UK Medical Research Council and Wellcome Trust/ GR - the University of Bristol provide core support for ALSPAC/ GR - the School of Biosciences at the University of Nottingham, UK./ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250702 PL - England TA - Andrology JT - Andrology JID - 101585129 RN - 0 (Leydig insulin-like protein) RN - 0 (Insulin) RN - 0 (Insulin-Like Peptides) RN - 0 (Proteins) SB - IM MH - Humans MH - Male MH - *Leydig Cells/metabolism/physiology MH - Adolescent MH - *Body Mass Index MH - *Insulin/blood MH - *Insulin-Like Peptides MH - Female MH - Child MH - Young Adult MH - Pregnancy MH - *Proteins/metabolism MH - Longitudinal Studies MH - Infant MH - Child, Preschool MH - Adult PMC - PMC13266448 OTO - NOTNLM OT - ALSPAC OT - INSL3 OT - Leydig cell OT - chickenpox OT - hypogonadism OT - inflammation OT - obesity COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/07/03 06:27 MHDA- 2026/06/15 11:37 PMCR- 2026/06/15 CRDT- 2025/07/03 01:03 PHST- 2025/06/06 00:00 [revised] PHST- 2025/04/19 00:00 [received] PHST- 2025/06/20 00:00 [accepted] PHST- 2026/06/15 11:37 [medline] PHST- 2025/07/03 06:27 [pubmed] PHST- 2025/07/03 01:03 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - ANDR70091 [pii] AID - 10.1111/andr.70091 [doi] PST - ppublish SO - Andrology. 2026 Jul;14(5):1172-1182. doi: 10.1111/andr.70091. Epub 2025 Jul 2. PMID- 40602085 OWN - NLM STAT- MEDLINE DCOM- 20250725 LR - 20250725 IS - 1873-6297 (Electronic) IS - 0001-6918 (Linking) VI - 258 DP - 2025 Aug TI - Building respect, fairness, and collaboration through physical education: A primary school intervention. PG - 105187 LID - S0001-6918(25)00500-1 [pii] LID - 10.1016/j.actpsy.2025.105187 [doi] AB - This study evaluates the effectiveness of a primary school intervention designed to foster fair-play, respect, and inclusion through physical education. Grounded in social learning theory and structural-developmental teaching, the program aimed to enhance students' moral decision-making, social behavior, and physical activity levels. Sixty-four students (aged 9-10 years) participated in the seven-month intervention, which integrated classroom lessons and physical activities. Mixed-methods data collection included validated questionnaires (PAQ-C, FPPEQ, AMDM-Q, RSEQ, PSE) and interviews with students and teachers. Findings revealed significant increases in physical activity levels, particularly in non-active students, alongside enhanced respect, collaboration, and self-esteem. Teachers noted improvements in emotional regulation, self-regulation, and rule adherence. Despite occasional inappropriate behaviors, this study highlights the potential of combining physical education with social-emotional learning strategies to support psychosocial development in primary school children. These results underscore the importance of integrating such programs into educational curricula. CI - Copyright (c) 2025 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Russo, Gabriele AU - Russo G AD - Department of Economics, Engineering, Society, and Business Organization, University of Tuscia, Largo dell'Universita, Viterbo, 01100, Italy; Department of Education and Human Sciences, University of Modena and Reggio-Emilia, V.le Timavo, 93, Reggio - Emilia, 42121, Italy; Department for Life Quality Studies, University of Bologna, C.so D'Augsuto, 237, Rimini, 47921, Italy. Electronic address: gabriele.russo@unitus.it. FAU - Paganelli, Valentina AU - Paganelli V AD - Department of Education and Human Sciences, University of Modena and Reggio-Emilia, V.le Timavo, 93, Reggio - Emilia, 42121, Italy. FAU - Ceciliani, Andrea AU - Ceciliani A AD - Department for Life Quality Studies, University of Bologna, C.so D'Augsuto, 237, Rimini, 47921, Italy. LA - eng PT - Journal Article DEP - 20250701 PL - Netherlands TA - Acta Psychol (Amst) JT - Acta psychologica JID - 0370366 SB - IM MH - Humans MH - Child MH - *Physical Education and Training/methods MH - Female MH - Male MH - Schools MH - *Cooperative Behavior MH - *Students/psychology MH - *Social Behavior MH - Exercise/psychology MH - Self Concept MH - *Social Learning OTO - NOTNLM OT - Fair-play OT - Intervention OT - Mixed-methods OT - Moral decision OT - Physical self-efficacy OT - Self-esteem COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/07/03 00:27 MHDA- 2025/07/25 06:38 CRDT- 2025/07/02 18:04 PHST- 2025/03/25 00:00 [received] PHST- 2025/06/12 00:00 [revised] PHST- 2025/06/13 00:00 [accepted] PHST- 2025/07/25 06:38 [medline] PHST- 2025/07/03 00:27 [pubmed] PHST- 2025/07/02 18:04 [entrez] AID - S0001-6918(25)00500-1 [pii] AID - 10.1016/j.actpsy.2025.105187 [doi] PST - ppublish SO - Acta Psychol (Amst). 2025 Aug;258:105187. doi: 10.1016/j.actpsy.2025.105187. Epub 2025 Jul 1. PMID- 40602073 OWN - NLM STAT- MEDLINE DCOM- 20250729 LR - 20260726 IS - 1872-7654 (Electronic) IS - 0301-2115 (Print) IS - 0301-2115 (Linking) VI - 312 DP - 2025 Aug TI - Associations of adverse childhood experiences (ACE) with pregnancy outcomes in people with cardiac disease. PG - 114547 LID - S0301-2115(25)00823-1 [pii] LID - 10.1016/j.ejogrb.2025.114547 [doi] AB - BACKGROUND: Though there is a growing fund of knowledge on how Adverse Childhood Experiences (ACEs) affect pregnancy, less is known about potential intergenerational effects to the fetus in high-risk pregnancies such as those with cardiac complications. This is critical since maternal cardiac disease is one of the most common causes of maternal mortality. This study investigates the associations between exposure to ACEs and perinatal outcomes in pregnant adults with cardiovascular disease. METHODS: This was a prospective cohort of pregnant individuals with cardiac disease who delivered at a single tertiary care institution from 2012 to 2022. Demographics, pregnancy complications, and neonatal outcomes from their first recorded pregnancy were abstracted from medical records. Perinatal outcomes, including preeclampsia, gestational diabetes, preterm delivery (<34 weeks), fetal growth restriction (FGR), 5-minute APGAR score < 8, small for gestational age (SGA) and intrauterine fetal demise (IUFD) were compared to ACE scores from validated ACE questionnaires using multivariable logistic regression models adjusting for BMI and chronic hypertension. RESULTS: Out of 323 people who met inclusion criteria, 113 (35 %) completed the ACE questionnaire. Of those, 54 % experienced at least one ACE, while 20 % experienced 4 or more. After adjusting for confounders, the odds of FGR increased by 30 % with each additional ACE (aOR: 1.30 (1.02 - 1.66); P = 0.03). There was one intrauterine fetal demise, which was among those who experienced 4 or more ACEs. CONCLUSION: Our study showed that 1 in 2 pregnant people with cardiac conditions experienced ACEs and 1 in 5 experienced 4 or more ACEs. Having a greater number of ACEs was associated with FGR in our study, which highlights the potential benefit of screening for ACEs at prenatal visits. This study expands on the growing data showing an association between ACEs and adverse pregnancy outcomes. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Jimenez Ramirez, Norma AU - Jimenez Ramirez N AD - Stanford School of Medicine, 291 Campus Drive, Stanford, CA 94305, USA. Electronic address: jime0094@umn.edu. FAU - Panelli, Danielle AU - Panelli D AD - Stanford University Department of Obstetrics and Gynecology, Maternal Fetal Medicine Division, 300 Pasteur Drive, Stanford, CA 94305, USA. FAU - Padron, Elisa AU - Padron E AD - Stanford School of Medicine, 291 Campus Drive, Stanford, CA 94305, USA. FAU - Veliz-Dominguez, Lisandra AU - Veliz-Dominguez L AD - Stanford School of Medicine, 291 Campus Drive, Stanford, CA 94305, USA. FAU - Lee, Christine AU - Lee C AD - Stanford University Department of Obstetrics and Gynecology, Maternal Fetal Medicine Division, 300 Pasteur Drive, Stanford, CA 94305, USA. FAU - Bianco, Katherine AU - Bianco K AD - Stanford University Department of Obstetrics and Gynecology, Maternal Fetal Medicine Division, 300 Pasteur Drive, Stanford, CA 94305, USA. LA - eng GR - K23 HD113845/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20250625 PL - Ireland TA - Eur J Obstet Gynecol Reprod Biol JT - European journal of obstetrics, gynecology, and reproductive biology JID - 0375672 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Adult MH - *Pregnancy Outcome/epidemiology MH - Prospective Studies MH - *Adverse Childhood Experiences/statistics & numerical data MH - *Heart Diseases/epidemiology MH - Infant, Newborn MH - Fetal Growth Retardation/epidemiology MH - *Pregnancy Complications, Cardiovascular/epidemiology MH - Premature Birth/epidemiology MH - Infant, Small for Gestational Age MH - *Pregnancy Complications/epidemiology PMC - PMC12277029 MID - NIHMS2095213 OTO - NOTNLM OT - ACE OT - Cardio-obstetrics OT - Cardiovascular OT - FGR OT - High-risk pregnancy COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/07/03 00:27 MHDA- 2025/07/29 18:32 PMCR- 2026/06/25 CRDT- 2025/07/02 18:04 PHST- 2024/10/29 00:00 [received] PHST- 2025/06/01 00:00 [revised] PHST- 2025/06/23 00:00 [accepted] PHST- 2025/07/29 18:32 [medline] PHST- 2025/07/03 00:27 [pubmed] PHST- 2025/07/02 18:04 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - S0301-2115(25)00823-1 [pii] AID - 10.1016/j.ejogrb.2025.114547 [doi] PST - ppublish SO - Eur J Obstet Gynecol Reprod Biol. 2025 Aug;312:114547. doi: 10.1016/j.ejogrb.2025.114547. Epub 2025 Jun 25. PMID- 40601992 OWN - NLM STAT- MEDLINE DCOM- 20250809 LR - 20250809 IS - 1872-6232 (Electronic) IS - 0378-3782 (Linking) VI - 208 DP - 2025 Sep TI - Association of eating behaviors and parental feeding attitudes with weight-for-height Z score in children aged 0-2 years. PG - 106324 LID - S0378-3782(25)00134-3 [pii] LID - 10.1016/j.earlhumdev.2025.106324 [doi] AB - The aim of this study was to develop a questionnaire suitable for the 0-2 years old children with feeding problems in pediatric outpatient clinics and to investigate the association of eating behaviors and parental feeding attitudes with weight-for-height Z score (WHZ). We developed the questionnaire of Children's eating behaviors and Parental feeding attitudes (CEB-PFA), including 7 subscales with Eating behaviors, Picky eating, Food texture, Parental psychology, Feeding behaviors, Feeding knowledge, and Family factors, which was completed by parents of children aged 0-2 years in pediatric clinics. We conducted a reliability analysis of the CEB-PFA and examined gender and age differences in eating behaviors and parental feeding attitudes. Regression models assessed the association of eating behaviors, parental feeding attitudes, and weight-for-height Z scores of children aged 0-2 years, by controlling for month of age, sex, height-for-age Z scores (HAZ), small for gestational age infant (SGA), premature, Cow's milk protein allergy (CMPA), the child's Primary feeder, and the questionnaire filler. The subscales demonstrated satisfactory internal reliability (Cronbach's alpha ranging from 0.539 to 0.808). Significant age differences were observed in the Parental Feeding Behaviors subscale, and a correlation was found between WHZ and both parental psychology and feeding behaviors. This study confirmed that parental psychology and feeding behaviors were significantly associated with weight-for-height Z scores in infants and young children and provide child healthcare professionals with a potential tool to identify the primary causes of feeding difficulties in infants and young children. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Lv, Lina AU - Lv L AD - Department of Pediatric Health Care, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, China; Zhejiang Key Laboratory of Neanatal Diseases, Hangzhou, 310052, China. FAU - Xu, Xin AU - Xu X AD - Department of Pediatric Health Care, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, China; Zhejiang Key Laboratory of Neanatal Diseases, Hangzhou, 310052, China. FAU - Qi, Ye AU - Qi Y AD - Department of Pediatric Health Care, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, China; Zhejiang Key Laboratory of Neanatal Diseases, Hangzhou, 310052, China. FAU - Wang, Shasha AU - Wang S AD - Department of Pediatric Health Care, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, China; Zhejiang Key Laboratory of Neanatal Diseases, Hangzhou, 310052, China. FAU - Zhu, Liuyan AU - Zhu L AD - Department of Pediatric Health Care, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, China; Zhejiang Key Laboratory of Neanatal Diseases, Hangzhou, 310052, China. FAU - Shao, Jie AU - Shao J AD - Department of Pediatric Health Care, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, China; Zhejiang Key Laboratory of Neanatal Diseases, Hangzhou, 310052, China. Electronic address: Shaojie@zju.edu.cn. LA - eng PT - Journal Article DEP - 20250618 PL - Ireland TA - Early Hum Dev JT - Early human development JID - 7708381 SB - IM MH - Humans MH - Infant MH - *Feeding Behavior/psychology MH - Male MH - Female MH - Child, Preschool MH - *Parents/psychology MH - Surveys and Questionnaires MH - *Body Weight MH - *Body Height MH - Infant, Newborn OTO - NOTNLM OT - Children OT - Eating behaviors OT - Parental feeding attitudes OT - Weight-for-height Z score COIS- Declaration of competing interest The authors declare that there is no conflict of interest. EDAT- 2025/07/02 18:47 MHDA- 2025/08/10 06:16 CRDT- 2025/07/02 17:59 PHST- 2025/04/16 00:00 [received] PHST- 2025/06/10 00:00 [revised] PHST- 2025/06/16 00:00 [accepted] PHST- 2025/08/10 06:16 [medline] PHST- 2025/07/02 18:47 [pubmed] PHST- 2025/07/02 17:59 [entrez] AID - S0378-3782(25)00134-3 [pii] AID - 10.1016/j.earlhumdev.2025.106324 [doi] PST - ppublish SO - Early Hum Dev. 2025 Sep;208:106324. doi: 10.1016/j.earlhumdev.2025.106324. Epub 2025 Jun 18. PMID- 40600726 OWN - NLM STAT- MEDLINE DCOM- 20250924 LR - 20250924 IS - 1827-1928 (Electronic) IS - 0022-4707 (Linking) VI - 65 IP - 9 DP - 2025 Sep TI - Test-retest reliability and criterion validity of three self-report questionnaires for assessing physical activity levels in Brazilian military. PG - 1226-1234 LID - 10.23736/S0022-4707.25.16416-5 [doi] AB - BACKGROUND: This study aimed to examine the reliability and criterion validity of three physical activity questionnaires in Brazilian military soldiers. METHODS: A convenience sample of 109 male Air Force soldiers (18.86+/-0.36 years of age and 22.59+/-2.58 kg/m(2) body mass index) completed the Brazilian Portuguese versions of the two-item PACE+, the Godin-Shepard Leisure-Time Physical Activity Questionnaire (GSLTPAQ) and the Baecke's Habitual Physical Activity Questionnaire (BHPAQ) twice (day one and six weeks after), for test-retest purposes. The criterion validity of these measures was assessed against the soldiers' cardiorespiratory fitness performance by Cooper's 12-minute run test. RESULTS: The intraclass correlation coefficient (ICC) results indicated excellent reliability for the BHPAQ (ICC=0.85) and moderate to good reliability for the PACE+ and GSLTPAQ (ICC=0.50 and 0.63, respectively). The Bland-Altman plots demonstrated good agreement and lower bias for the PACE+ and the BHPAQ (mean differences = 1.01 and -0.06, respectively). The significant correlations with the cardiorespiratory fitness levels were only observed for PACE+ (rho=0.22), BHPAQ sports dimension (rho=0.29), and BHPAQ total (rho=0.24) scores. CONCLUSIONS: The BHPAQ showed to be the most suitable of these three self-report physical activity questionnaires for use in these military personnel, revealing higher test-retest reliability and criterion validity. FAU - Fernandes, Helder M AU - Fernandes HM AD - Sports Sciences Department, Polytechnic Institute of Guarda, Guarda, Portugal - hmfernandes@ipg.pt. AD - Sport Physical activity and health Research and INnovation CenTer (SPRINT), Guarda, Portugal - hmfernandes@ipg.pt. FAU - Silva, Nadia S AU - Silva NS AD - Postgraduate Program in Exercise and Sports Sciences, Rio de Janeiro State University, Rio de Janeiro, Brazil. FAU - Esteves, Pedro AU - Esteves P AD - Sports Sciences Department, Polytechnic Institute of Guarda, Guarda, Portugal. AD - Sport Physical activity and health Research and INnovation CenTer (SPRINT), Guarda, Portugal. FAU - Machado-Rodrigues, Aristides M AU - Machado-Rodrigues AM AD - Faculty of Sport Sciences and Physical Education, University of Coimbra, Coimbra, Portugal. AD - Centro Interdisciplinar de Performance Humana (CIPER-UC), University of Coimbra, Coimbra, Portugal. FAU - Doimo, Leonice A AU - Doimo LA AD - Postgraduate Program in Operational Human Performance, Air Force University, Sao Paulo, Brazil. FAU - Ferreira, Luiz F AU - Ferreira LF AD - Postgraduate Program in Operational Human Performance, Air Force University, Sao Paulo, Brazil. AD - School of Aeronautics Specialists, Brazilian Air Force, Sao Paulo, Brazil. FAU - Bomfim, Alexander B AU - Bomfim AB AD - Postgraduate Program in Operational Human Performance, Air Force University, Sao Paulo, Brazil. FAU - Resende, Helder G AU - Resende HG AD - Postgraduate Program in Operational Human Performance, Air Force University, Sao Paulo, Brazil. LA - eng PT - Journal Article PT - Validation Study DEP - 20250702 PL - Italy TA - J Sports Med Phys Fitness JT - The Journal of sports medicine and physical fitness JID - 0376337 SB - IM MH - Humans MH - Male MH - *Military Personnel MH - Brazil MH - Reproducibility of Results MH - *Exercise MH - Young Adult MH - *Self Report MH - Adolescent MH - Surveys and Questionnaires/standards MH - Cardiorespiratory Fitness MH - Exercise Test EDAT- 2025/07/02 12:28 MHDA- 2025/09/24 13:01 CRDT- 2025/07/02 09:17 PHST- 2025/09/24 13:01 [medline] PHST- 2025/07/02 12:28 [pubmed] PHST- 2025/07/02 09:17 [entrez] AID - S0022-4707.25.16416-5 [pii] AID - 10.23736/S0022-4707.25.16416-5 [doi] PST - ppublish SO - J Sports Med Phys Fitness. 2025 Sep;65(9):1226-1234. doi: 10.23736/S0022-4707.25.16416-5. Epub 2025 Jul 2. PMID- 40600279 OWN - NLM STAT- In-Process LR - 20260226 IS - 1558-688X (Electronic) IS - 0031-5125 (Linking) VI - 133 IP - 2 DP - 2026 Apr TI - AI-Powered Assessment of Motor Development: Using Platforms Like KineticAI to Analyze Fundamental Movement Skills in Children. PG - 276-298 LID - 10.1177/00315125251357047 [doi] AB - The aim of this study is to examine the precision, dependability, and relevance of AI-based evaluations in contrast to conventional human evaluations. In all, 200 7-8-year-old students from urban and suburban schools participated in the study. Based on movement speed, accuracy, and smoothness, KineticAI's assessment of their motor skills divided them into three categories: proficiency, developing, and emerging. A thorough examination of KineticAI's validity and reliability was ensured by evaluating its psychometric qualities using COSMIN criteria. Furthermore, AI-generated scores and human evaluator ratings were compared using TGMD-3 as a standard. Mean Absolute Error (MAE), Intraclass Correlation Coefficients (ICC), and Bland-Altman plots were among the statistical techniques used to evaluate the degree of agreement. With an ICC of 0.94, the results show that KineticAI achieves great accuracy and dependability, showing strong consistency with human judgments. With running (3.8), jumping (4.2), hopping (5.1), and balancing (4.9) points, the AI system demonstrated a negligible mean absolute error (MAE) across motor skills, thereby proving its accuracy. Disparities in motor proficiency were also found by gender and school, with suburban girls scoring the lowest and urban boys the highest. These results highlight how crucial it is to provide everyone with fair access to organized physical activity programs to close developmental gaps. The study indicates that KineticAI offers a scalable, objective, and efficient alternative to traditional motor assessments. It is a valuable tool for use in schools, rehabilitation clinics, and sports training programs. FAU - Guo, Jing Xuan AU - Guo JX AD - School of Physical Education and Health Science, Mudanjiang Normal University, Mudanjiang, China. RINGGOLD: 47823 FAU - Zhang, Gao Hua AU - Zhang GH AD - School of Economics and Management, Wuhan Sports University, Wuhan, China. RINGGOLD: 105807 FAU - Zhang, You Ming AU - Zhang YM AUID- ORCID: 0009-0003-8035-721X AD - School of Physical Education and Health Science, Mudanjiang Normal University, Mudanjiang, China. RINGGOLD: 47823 LA - eng PT - Journal Article DEP - 20250702 PL - United States TA - Percept Mot Skills JT - Perceptual and motor skills JID - 0401131 SB - IM OTO - NOTNLM OT - artificial intelligence OT - child development OT - motor skill assessment OT - movement analysis OT - psychometric validation COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/07/02 06:29 MHDA- 2025/07/02 06:29 CRDT- 2025/07/02 05:33 PHST- 2025/07/02 06:29 [pubmed] PHST- 2025/07/02 06:29 [medline] PHST- 2025/07/02 05:33 [entrez] AID - 10.1177/00315125251357047 [doi] PST - ppublish SO - Percept Mot Skills. 2026 Apr;133(2):276-298. doi: 10.1177/00315125251357047. Epub 2025 Jul 2. PMID- 40598696 OWN - NLM STAT- MEDLINE DCOM- 20250702 LR - 20260602 IS - 2050-6511 (Electronic) IS - 2050-6511 (Linking) VI - 26 IP - 1 DP - 2025 Jul 1 TI - Exploration of adverse event profiles for cefotaxime: a disproportionality analysis using the FDA adverse event reporting system. PG - 129 LID - 10.1186/s40360-025-00960-w [doi] LID - 129 AB - BACKGROUND: Cefotaxime has been widely used in the clinical treatment of infections. However, there is still a lack of systematic researches for the adverse event profiles of cefotaxime through large-scale post-marketing monitoring. METHODS: This study investigated the adverse event profiles for cefotaxime in the Food and Drug Administration Adverse Event Reporting System database, delving into clinical characteristics, adverse event signals and variations in these signals across subgroups. RESULTS: Compared with Asia, Europe and America more commonly reported once-daily frequency. New severe hepatobiliary disorders were observed in neonates, children, or underweight elderly patients even when using adjusted doses below 1 g. Significant variations in adverse event signals were identified in relation to continent, dose, onset time, and outcome. CONCLUSIONS: The existence of non-recommended frequency in Europe and America warrants clinical attention when using cefotaxime. The identification of new severe hepatobiliary disorders highlights the critical need for personalized dosing strategies and intensified liver function monitoring for neonates, children, and elderly individuals with lower body weights. Furthermore, the differences in adverse event signals across subgroups underscore the necessity of developing targeted monitoring protocols. Further research is required to validate the association. CLINICAL TRIAL NUMBER: Not applicable. CI - (c) 2025. The Author(s). FAU - Jiang, Cheng AU - Jiang C AD - Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Gucui Road NO. 234, Hangzhou, Zhejiang, 310012, China. AD - Zhejiang Provincial Key Laboratory of Disease-Syndrome Integrated Cancer Prevention and Treatment, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, 310012, China. AD - Zhejiang Provincial Key Laboratory of Traditional Chinese Medicine for Pharmacodynamic Material Basis Research of Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, 310012, China. FAU - Qian, Jiancheng AU - Qian J AD - Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Gucui Road NO. 234, Hangzhou, Zhejiang, 310012, China. FAU - Lu, Yingyan AU - Lu Y AD - Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Gucui Road NO. 234, Hangzhou, Zhejiang, 310012, China. FAU - Zheng, Junxian AU - Zheng J AD - Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Gucui Road NO. 234, Hangzhou, Zhejiang, 310012, China. zjx203337@sina.com. LA - eng GR - 2023RC141/Medical Science and Technology Project of Zhejiang Province/ GR - 2023ZF076/Traditional Chinese Medicine Science and Technology Project of Zhejiang Province/ GR - 2024ZL362/Traditional Chinese Medicine Science and Technology Project of Zhejiang Province/ GR - GZY-ZJ-SY-2402/State Administration of Traditional Chinese Medicine Science and Technology Department-Zhejiang Provincial Administration of Traditional Chinese Medicine Co-construction of Key Laboratory of Research on Prevention and Treatment for Depression Syndrome/ GR - KJTYSZX2025/Zhejiang Provincial Department of Science and Technology Research Institute Support Program/ PT - Journal Article DEP - 20250701 PL - England TA - BMC Pharmacol Toxicol JT - BMC pharmacology & toxicology JID - 101590449 RN - N2GI8B1GK7 (Cefotaxime) RN - 0 (Anti-Bacterial Agents) SB - IM MH - Humans MH - United States MH - *Cefotaxime/adverse effects MH - United States Food and Drug Administration MH - *Adverse Drug Reaction Reporting Systems/statistics & numerical data MH - *Anti-Bacterial Agents/adverse effects MH - Child MH - Infant MH - Child, Preschool MH - Aged MH - Infant, Newborn MH - Male MH - Adult MH - Female MH - Adolescent MH - Middle Aged MH - Europe/epidemiology MH - Databases, Factual MH - Young Adult PMC - PMC12220385 OTO - NOTNLM OT - Cefotaxime OT - Dosing frequency OT - FAERS OT - Hepatobiliary disorder OT - Subgroup analysis COIS- Declarations. Ethics approval and consent to participate: Not applicable. Ethical approval was not required for this study because we used the FAERS database, which is a free open-access database. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/07/02 06:28 MHDA- 2025/07/02 12:28 PMCR- 2025/07/01 CRDT- 2025/07/02 04:53 PHST- 2025/01/27 00:00 [received] PHST- 2025/05/29 00:00 [accepted] PHST- 2025/07/02 12:28 [medline] PHST- 2025/07/02 06:28 [pubmed] PHST- 2025/07/02 04:53 [entrez] PHST- 2025/07/01 00:00 [pmc-release] AID - 10.1186/s40360-025-00960-w [pii] AID - 960 [pii] AID - 10.1186/s40360-025-00960-w [doi] PST - epublish SO - BMC Pharmacol Toxicol. 2025 Jul 1;26(1):129. doi: 10.1186/s40360-025-00960-w. PMID- 40597660 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1471-230X (Electronic) IS - 1471-230X (Linking) VI - 25 IP - 1 DP - 2025 Jul 1 TI - Ultrasound-derived fat fraction: a novel approach for assessing Wilson's disease-related hepatic steatosis. PG - 465 LID - 10.1186/s12876-025-03928-6 [doi] LID - 465 AB - BACKGROUND AND OBJECTIVES: Ultrasound-derived fat fraction (UDFF) is a novel, non-invasive, rapid, and cost-effective technology that assesses liver fat content in various hepatic diseases. Its use in evaluating hepatic steatosis in Wilson's disease (WD) remains largely unexplored. This study aimed to verify the clinical utility and measurement consistency of UDFF in assessing hepatic steatosis in WD, investigate the relationship between BMI and the severity of hepatic steatosis in WD patients, and determine if UDFF is an effective indicator for this condition. METHODS: This retrospective study involved 89 patients diagnosed with WD. The demographic characteristics, body mass index (BMI), conventional ultrasound examination, liver shear wave elastography, and ultrasound-derived fat fraction (UDFF) detection data were collected and statistically analyzed. The degree of hepatic steatosis was evaluated using the visual scoring method known as the Hamaguchi score. The Bland-Altman plot was used to analyze the intra-observer and inter-observer consistency of UDFF measurements. The Spearman correlation analysis was conducted to explore the correlations among BMI, UDFF, and the Hamaguchi score. Additionally, confounding factors were included to analyze whether UDFF was an independent influencing factor for WD hepatic steatosis. The receiver operating characteristic (ROC) curve was utilized to determine the cutoff value of UDFF for diagnosing WD hepatic steatosis and its diagnostic efficacy. RESULTS: The Bland-Altman analysis showed bias values of 5.7% and 1.1% for intra-observer variability of a junior and a senior sonologist, respectively, and 14.9% for inter-observer variability. Univariate analysis showed no significant correlation between BMI and the Hamaguchi score (r = 0.08, P = 0.478). However, there was a positive correlation between UDFF and the Hamaguchi score (r = 0.71, P < 0.001). Multivariate analysis indicated a significant correlation between UDFF and WD hepatic steatosis, with a regression coefficient of 1.243, OR of 3.465, and 95% CI of 1.617-10.51 (P = 0.008). ROC curve analysis demonstrated that the optimal cutoff value of UDFF for diagnosing WD hepatic steatosis was 4.5%, with an AUROC of 0.80 (95% CI: 71 - 90%), sensitivity of 90%, and specificity of 80%. CONCLUSION: The clinical operation of UDFF exhibits high repeatability. In patients with WD, there may be a paradoxical phenomenon where those with low or normal BMI co-exist with hepatic steatosis. UDFF can serve as a valuable tool for the quantitative assessment of WD hepatic steatosis. Our study broadens the clinical applications of UDFF. FAU - Yan, Li AU - Yan L AD - Department of Ultrasound, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, MeiShan Road, Anhui, 230031, P.R. China. FAU - Fu, Jin AU - Fu J AD - Department of Ultrasound, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, MeiShan Road, Anhui, 230031, P.R. China. FAU - Juan, Ni Juan AU - Juan NJ AD - Department of Ultrasound, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, MeiShan Road, Anhui, 230031, P.R. China. FAU - Qi, Li Bao AU - Qi LB AD - Department of Ultrasound, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, MeiShan Road, Anhui, 230031, P.R. China. renandwo@163.com. FAU - Ping, Wang Jing AU - Ping WJ AD - Department of Ultrasound, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, MeiShan Road, Anhui, 230031, P.R. China. hf_wjp@163.com. LA - eng PT - Journal Article DEP - 20250701 PL - England TA - BMC Gastroenterol JT - BMC gastroenterology JID - 100968547 SB - IM MH - Humans MH - *Hepatolenticular Degeneration/complications/diagnostic imaging MH - Female MH - Male MH - Retrospective Studies MH - *Fatty Liver/diagnostic imaging/etiology MH - Adult MH - Ultrasonography/methods MH - Body Mass Index MH - Adolescent MH - ROC Curve MH - Young Adult MH - Elasticity Imaging Techniques MH - *Liver/diagnostic imaging MH - Severity of Illness Index MH - Middle Aged MH - *Adipose Tissue/diagnostic imaging MH - Observer Variation PMC - PMC12211759 OTO - NOTNLM OT - Hamaguchi's score OT - Hepatic steatosis OT - Liver parenchyma brightness OT - Ultrasound-derived fat fraction OT - Wilson's disease COIS- Declarations. Ethics approval and consent to participate: This retrospective study was conducted in accordance with the ethical guidelines of the Declaration of Helsinki. The requirement for individual consent was waived by the committee because of the retrospective nature of the study. The full name of the ethics committee that waived the requirement of informed consent for our study is the Ethics Committee of the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine. Consent for publication: All authors read and approved the final manuscript. Competing interests: The authors declare no competing interests. EDAT- 2025/07/02 06:28 MHDA- 2026/06/27 00:48 PMCR- 2025/07/01 CRDT- 2025/07/02 04:11 PHST- 2025/01/26 00:00 [received] PHST- 2025/04/22 00:00 [accepted] PHST- 2026/06/27 00:48 [medline] PHST- 2025/07/02 06:28 [pubmed] PHST- 2025/07/02 04:11 [entrez] PHST- 2025/07/01 00:00 [pmc-release] AID - 10.1186/s12876-025-03928-6 [pii] AID - 3928 [pii] AID - 10.1186/s12876-025-03928-6 [doi] PST - epublish SO - BMC Gastroenterol. 2025 Jul 1;25(1):465. doi: 10.1186/s12876-025-03928-6. PMID- 40597435 OWN - NLM STAT- MEDLINE DCOM- 20250702 LR - 20250704 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 13 IP - 1 DP - 2025 Jul 1 TI - Unraveling the link: exploring violence in connection to socioeconomic status, demographic factors, and substance use in adolescents and young adults. PG - 655 LID - 10.1186/s40359-025-02961-0 [doi] LID - 655 AB - BACKGROUND: There is a lack of reliable information regarding the factors associated with violence in underdeveloped countries. This study examines the relationship between socioeconomic status (SES), demographic factors, substance use, and violence in the Fasa Youth Cohort (FYC), focusing on how these risk factors affect both sexes. METHODS: Using baseline data from 3013 participants aged 15-34 in the FYC, we assessed violence and its potential predictors via validated questionnaires. Statistical analyses included chi-square tests, independent t-tests, and multivariate logistic regression to identify associations. Effect sizes were reported as Cramer's V for chi-square tests and Cohen's d for independent t-tests. P-values less than 0.05 were considered statistically significant. RESULTS: Violent behavior was reported in 45.6% of participants. High SES was significantly associated with increased violence (OR = 1.61, 95% CI: 1.33-1.95; p < 0.001). Additional risk factors included female sex, alcohol use, smoking, high BMI, and depression. Furthermore, sex-differentiated analysis revealed that high SES, early marriage, depression, smoking, and opioid addiction, were associated with greater violence in both sexes. However, intermediate SES and high BMI were risk factors only among women. CONCLUSION: Implementing measures to prevent and treat depression, decrease smoking, opiate and alcohol use, regulate individuals' BMI, discourage early marriage, and promote empathetic behaviors might effectively mitigate violence in society. CI - (c) 2025. The Author(s). FAU - Rabiei, Saman AU - Rabiei S AUID- ORCID: 0009-0001-0053-6273 AD - Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran. AD - Department of Psychiatry, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran. FAU - Kamyab, Parnia AU - Kamyab P AUID- ORCID: 0000-0002-6578-8893 AD - Research Center for Psychiatry and Behavioral Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Dehghan, Azizallah AU - Dehghan A AD - Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran. FAU - Bagheri, Zahra AU - Bagheri Z AUID- ORCID: 0009-0001-4037-191X AD - Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran. FAU - Fakhraei, Bahareh AU - Fakhraei B AD - Department of Psychiatry, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran. b.fakhraee@gmail.com. LA - eng PT - Journal Article DEP - 20250701 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Female MH - Male MH - Adolescent MH - *Substance-Related Disorders/epidemiology/psychology MH - Young Adult MH - Adult MH - *Violence/statistics & numerical data/psychology MH - Risk Factors MH - *Social Class MH - Surveys and Questionnaires MH - Sex Factors PMC - PMC12210511 OTO - NOTNLM OT - Adolescence OT - Aggression OT - Depression OT - Marriage OT - Socioeconomic status OT - Substance use OT - Violence OT - Youth COIS- Declarations. Ethics approval and consent to participate: This study adhered to the principles outlined in the Declaration of Helsinki, ensuring ethical conduct throughout the study. We obtained official approval from the Ethics Committee of Fasa University of Medical Sciences with code IR.FUMS.REC.1402.028. The studies were conducted in accordance with the local legislation and institutional requirements. The participants and/or their legal guardians provided their written informed consent to participate in this study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/07/02 06:28 MHDA- 2025/07/02 12:31 PMCR- 2025/07/01 CRDT- 2025/07/02 04:06 PHST- 2024/10/09 00:00 [received] PHST- 2025/05/30 00:00 [accepted] PHST- 2025/07/02 12:31 [medline] PHST- 2025/07/02 06:28 [pubmed] PHST- 2025/07/02 04:06 [entrez] PHST- 2025/07/01 00:00 [pmc-release] AID - 10.1186/s40359-025-02961-0 [pii] AID - 2961 [pii] AID - 10.1186/s40359-025-02961-0 [doi] PST - epublish SO - BMC Psychol. 2025 Jul 1;13(1):655. doi: 10.1186/s40359-025-02961-0. PMID- 40597260 OWN - NLM STAT- MEDLINE DCOM- 20250702 LR - 20250704 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 13 IP - 1 DP - 2025 Jul 1 TI - The effect of physical activity on altruistic behaviour among university students: a chain-mediated effect. PG - 711 LID - 10.1186/s40359-025-02998-1 [doi] LID - 711 AB - BACKGROUND: Physical activity is a vital means for college students to maintain physical health, while altruism is a desirable psychological trait and a cornerstone of mental health. However, direct evidence exploring the relationship between physical activity and altruistic behavior remains limited. This study investigates how physical activity influences altruistic behavior among university students, focusing on the chain-mediated roles of social support and personality extraversion. METHODS: A sample of 507 Chinese university students (293 males, 214 females; aged 17-25) completed validated scales, including the Physical Activity Rating Scale (PARS-3), Social Support Scale, Personality Extraversion Dimension of the Chinese Big Five Personality Inventory (CBF-PI-B), and Altruistic Behavior Questionnaire. Data were analyzed using SPSS 27.0 and Hayes' PROCESS macro (Model 6) to test correlations, regression, and mediation effects, with gender and grade as control variables. RESULTS: Physical activity showed a significant positive correlation with altruistic behavior (r = 0.434, p < 0.01).Social support (beta = 0.0043,95% CI = [0.0027,0.0061]) and personality extraversion (beta = 0.0020,95% CI = [0.0011,0.0031]) independently mediated this relationship. A chain mediation effect was confirmed, where physical activity enhanced altruistic behavior sequentially through social support and extraversion (beta = 0.0028,95% CI = [0.0017,0.0042]). Gender and grade differences were observed, with males and upperclassmen exhibiting higher physical activity and altruistic tendencies. CONCLUSION: Physical activity positively predicts altruistic behavior among college students, mediated by social support and personality extraversion. These findings highlight the importance of integrating physical activity into university policies to foster mental health, social networks, and prosocial traits, ultimately cultivating altruistic behaviors and socially responsible individuals. CI - (c) 2025. The Author(s). FAU - Jiang, Yong AU - Jiang Y AD - School of Physical Education, Liaoning Normal University, Dalian, China. Jiangyongdl@sina.com. FAU - Wang, Tianyi AU - Wang T AD - School of Physical Education, Liaoning Normal University, Dalian, China. LA - eng PT - Journal Article DEP - 20250701 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Male MH - Female MH - *Altruism MH - *Students/psychology MH - Adolescent MH - Young Adult MH - *Exercise/psychology MH - Universities MH - Adult MH - *Social Support MH - *Extraversion, Psychological MH - Surveys and Questionnaires MH - China MH - Personality PMC - PMC12220275 OTO - NOTNLM OT - Altruistic behaviour OT - Personality extraversion OT - Physical activity OT - Social support COIS- Declarations. Ethics approval and consent to participate: The design of this study followed the guidelines and regulations of the Declaration of Helsinki and approved by Ethics Committee of Liaoning Normal University (LL2025016), and all participants signed an informed consent form and were paid for their participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/07/02 06:28 MHDA- 2025/07/02 06:29 PMCR- 2025/07/01 CRDT- 2025/07/02 03:59 PHST- 2025/02/09 00:00 [received] PHST- 2025/06/06 00:00 [accepted] PHST- 2025/07/02 06:29 [medline] PHST- 2025/07/02 06:28 [pubmed] PHST- 2025/07/02 03:59 [entrez] PHST- 2025/07/01 00:00 [pmc-release] AID - 10.1186/s40359-025-02998-1 [pii] AID - 2998 [pii] AID - 10.1186/s40359-025-02998-1 [doi] PST - epublish SO - BMC Psychol. 2025 Jul 1;13(1):711. doi: 10.1186/s40359-025-02998-1. PMID- 40597025 OWN - NLM STAT- MEDLINE DCOM- 20250702 LR - 20260620 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 25 IP - 1 DP - 2025 Jul 2 TI - The impact of long-term exercise on motor skills in children with ADHD: a three-level meta-analysis. PG - 497 LID - 10.1186/s12887-025-05857-5 [doi] LID - 497 AB - OBJECTIVE: This study aims to systematically evaluate the intervention effects of long-term exercise on motor skills in children with ADHD (Attention Deficit and Hyperactivity Disorder) using a three-level meta-analysis. METHODS: A computer-based search was conducted in four databases: Embase, The Cochrane Library, PubMed, and Web of Science, for randomized controlled trials related to the effects of long-term exercise on motor skills in children with ADHD, with search dates ranging from database inception to December 3, 2024. The risk of bias in the included studies was assessed using the Rob 2.0 tool. Effect sizes were synthesized, and influence analysis, moderator analysis, and publication bias assessment were conducted using the metafor package in R software. Evidence quality was evaluated using GRADEpro. RESULTS: A total of 9 studies were included. The intervention effect of long-term exercise on motor skills in children with ADHD was statistically significant (g = 0.72, 95% CI = (0.31, 1.14), P = 0.001), with a moderate level of evidence. Diagnosis method, exercise type, duration, frequency, and motor skill type were not found to be moderating factors (P > 0.05 for all). CONCLUSION: Long-term exercise can enhance motor skills in children with ADHD; however, this finding should be interpreted with caution. Further validation through large-scale randomized controlled trial is required in future research. CI - (c) 2025. The Author(s). FAU - Wang, Chengguo AU - Wang C AD - Department of Physical Education, China University of Petroleum (East China), Huangdao District, Qingdao city, 266580, China. FAU - You, Yang AU - You Y AD - Department of Physical Education, China University of Petroleum (East China), Huangdao District, Qingdao city, 266580, China. youyangupc66@163.com. FAU - Zhou, Jilan AU - Zhou J AD - Department of Physical Education, China University of Petroleum (East China), Huangdao District, Qingdao city, 266580, China. LA - eng GR - BLA220239/A study on the development model and co-parenting path of young children's physical ability/ PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20250702 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Attention Deficit Disorder with Hyperactivity/therapy/physiopathology MH - *Motor Skills MH - Child MH - *Exercise Therapy/methods MH - Randomized Controlled Trials as Topic MH - *Exercise MH - Time Factors PMC - PMC12219924 OTO - NOTNLM OT - ADHD OT - Children OT - Exercise OT - Meta-analysis OT - Motor skills COIS- Declarations. Ethics approval and consent to participate: This article is a systematic review and meta-analysis and does not involve any new studies with human participants performed by the authors. All included studies were conducted in accordance with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/07/02 06:28 MHDA- 2025/07/02 06:29 PMCR- 2025/07/02 CRDT- 2025/07/02 03:49 PHST- 2025/02/08 00:00 [received] PHST- 2025/06/06 00:00 [accepted] PHST- 2025/07/02 06:29 [medline] PHST- 2025/07/02 06:28 [pubmed] PHST- 2025/07/02 03:49 [entrez] PHST- 2025/07/02 00:00 [pmc-release] AID - 10.1186/s12887-025-05857-5 [pii] AID - 5857 [pii] AID - 10.1186/s12887-025-05857-5 [doi] PST - epublish SO - BMC Pediatr. 2025 Jul 2;25(1):497. doi: 10.1186/s12887-025-05857-5. PMID- 40596276 OWN - NLM STAT- MEDLINE DCOM- 20250702 LR - 20250704 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Jul 1 TI - Analysis of risk factors for poor wound healing after Nuss procedure for pectus excavatum and establishment of a predictive model. PG - 22271 LID - 10.1038/s41598-025-07373-z [doi] LID - 22271 AB - The Nuss procedure is a widely used treatment for pectus excavatum (PE) that significantly enhances the effectiveness of correction and improves patient satisfaction. However, it is not without its limitations. One common complication that patients face is poor wound healing (PWH). Identifying risk factors for poor wound healing and accurately predicting its occurrence are critical for improving patient outcomes. Currently, there is limited research on poor wound healing in postoperative patients, and there is an urgent need for more robust clinical studies. Over the past decade, we collected data on about 40 indicators from 581 patients who underwent Nuss surgery in our hospital. Lasso regression and multivariate regression analysis (MRA) were used to identify factors significantly associated with poor wound healing. Based on these factors, a prediction model using categorical boosting (CatBoost) theory was developed to assess the risk of PWH. Approximately 9% of patients experienced poor wound healing after the Nuss procedure. Among the 35 potential risk factors, we identified several key clinical indicators closely related to poor incision healing, including muscle thickness (MT), Haller short diameter variation (Haller SDV), relative muscle thickness (RMT), orthopedic triangle (OT), absolute sternal rotation angle (ASRA), and body mass index (BMI). Furthermore, we discovered that the orthopedic triangle, a critical factor in orthopedic plate shaping, played a significant role in predicting PWH (chi(2) = 42.91, df = 3, p < 0.001). The optimal range for the orthopedic triangle was defined as 0.48 to 0.57. Using these identified factors, we developed the NOWI-model (Nuss surgical incision complication prediction model), which was based on CatBoost theory. The model performed well on the validation dataset, achieving an AUC of 0.96 (95% CI: 0.92,0.99) and an F1-score of 0.80 for predicting PWH. Additionally, an online calculator was created based on this model to help clinicians assess the risk of poor wound healing. We also found that the maximum chest wall elevation during correction should not exceed 4 cm. This study not only identified the high-risk factors for poor wound healing after Nuss surgery and defined the optimal range of some factors for the first time, but also provided a clinical prediction model and a tool for assessing poor wound healing risk. The NOWI model offers a reliable approach for predicting postoperative complications and improving patient care. CI - (c) 2025. The Author(s). FAU - Sun, Haipeng AU - Sun H AD - Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China. FAU - Lin, Feng AU - Lin F AD - Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China. rosejieson@126.com. LA - eng PT - Journal Article DEP - 20250701 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Funnel Chest/surgery MH - *Wound Healing MH - Risk Factors MH - Male MH - Female MH - Adolescent MH - Child MH - Young Adult MH - *Postoperative Complications/etiology MH - Adult PMC - PMC12214908 OTO - NOTNLM OT - Nuss operation OT - Pectus excavatum (PE) OT - Poor wound healing (PWH) OT - Prediction model COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical standards: This study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of West China Hospital of Sichuan University, which agreed to waive informed consent from patients. The ethics number is 2023 (review number 1986), and patient information is anonymized and kept confidential to avoid personal privacy and commercial interests. EDAT- 2025/07/02 06:28 MHDA- 2025/07/02 06:29 PMCR- 2025/07/01 CRDT- 2025/07/02 03:05 PHST- 2024/12/14 00:00 [received] PHST- 2025/06/13 00:00 [accepted] PHST- 2025/07/02 06:29 [medline] PHST- 2025/07/02 06:28 [pubmed] PHST- 2025/07/02 03:05 [entrez] PHST- 2025/07/01 00:00 [pmc-release] AID - 10.1038/s41598-025-07373-z [pii] AID - 7373 [pii] AID - 10.1038/s41598-025-07373-z [doi] PST - epublish SO - Sci Rep. 2025 Jul 1;15(1):22271. doi: 10.1038/s41598-025-07373-z. PMID- 40595163 OWN - NLM STAT- MEDLINE DCOM- 20250702 LR - 20250704 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Jul 2 TI - Applicability of the Chinese weight self-stigma questionnaire and its relationships with depression, physical exercise, and quality of life. PG - 23039 LID - 10.1038/s41598-025-07951-1 [doi] LID - 23039 AB - This study aims to validate the psychometric properties of the Chinese College Students' Weight Self-Stigma Questionnaire (WSSQ), with a focus on examining its cross-cultural adaptability to provide evidence for localized measurement tools. It further seeks to explore the mechanism through which weight self-stigma influences quality of life satisfaction, elucidating the chain mediating effects of physical exercise (behavior) and depression-anxiety-stress (psychology) to fill the gap in mechanistic research on these pathways. Study 1 assessed validity and reliability via item analysis, exploratory factor analysis (EFA), and confirmatory factor analysis (CFA). Study 2 used the WSSQ (two dimensions: self-devaluation, Fear of Enacted Stigma), physical exercise scale (frequency, intensity, duration), DASS-21 (three subscales), and life satisfaction scale to construct structural equation models for testing chain mediation. Study 1's EFA extracted two factors (self-devaluation, Fear of Enacted Stigma) explaining 63.05% variance. CFA showed excellent fit (chi(2)/df = 1.22, RMSEA = 0.032, CFI = 0.992). Convergent validity (AVE = 0.562/0.605; CR = 0.884/0.901) and discriminant validity (AVE square root > inter-factor correlations) met standards, with strong internal consistency (Cronbach's alpha = 0.899). Study 2 found weight self-stigma negatively predicted life satisfaction (beta = -0.390, p < 0.001), with significant chain mediation via physical exercise and depression-anxiety-stress (indirect effect = 0.059, 95% CI [0.011, 0.133]). The Chinese WSSQ demonstrated robust reliability and validity among college students. Weight management interventions should target weight self-stigma reduction, fostering "psychology-behaviour-health" virtuous cycles through physical exercise promotion and mental health improvement to enhance life satisfaction. The scale serves as a valuable tool for weight-related research. CI - (c) 2025. The Author(s). FAU - Fu, Yuchao AU - Fu Y AD - Changzhi University, Changzhi, Shanxi, China. 18335503788@163.com. FAU - Liu, Jixiang AU - Liu J AD - Changzhi University, Changzhi, Shanxi, China. FAU - Lyu, Wei AU - Lyu W AD - Al-Farabi Kazakh National University, Almaty, Kazakhstan. LA - eng PT - Journal Article DEP - 20250702 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Male MH - Female MH - *Exercise/psychology MH - *Quality of Life/psychology MH - Surveys and Questionnaires MH - *Depression/psychology/epidemiology MH - Young Adult MH - *Social Stigma MH - China MH - Psychometrics MH - Adult MH - Students/psychology MH - *Body Weight MH - Reproducibility of Results MH - Self Concept MH - Adolescent PMC - PMC12216162 OTO - NOTNLM OT - College students OT - Depression-anxiety-stress OT - Physical exercise OT - Quality of life OT - Weight self-stigma COIS- Competing interests: The authors declare no competing interests. Ethics approval: This study is a psychological survey research, not an experimental psychology research. It is based on psychological experimental ethics, follows the general principles of seeking truth from facts, rigor and prudence, and protects the subject's right to informed consent and the confidentiality of survey data. EDAT- 2025/07/02 06:28 MHDA- 2025/07/02 06:29 PMCR- 2025/07/02 CRDT- 2025/07/02 01:55 PHST- 2025/01/29 00:00 [received] PHST- 2025/06/18 00:00 [accepted] PHST- 2025/07/02 06:29 [medline] PHST- 2025/07/02 06:28 [pubmed] PHST- 2025/07/02 01:55 [entrez] PHST- 2025/07/02 00:00 [pmc-release] AID - 10.1038/s41598-025-07951-1 [pii] AID - 7951 [pii] AID - 10.1038/s41598-025-07951-1 [doi] PST - epublish SO - Sci Rep. 2025 Jul 2;15(1):23039. doi: 10.1038/s41598-025-07951-1. PMID- 40593923 OWN - NLM STAT- MEDLINE DCOM- 20250702 LR - 20250704 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Jul 1 TI - GenAI exceeds clinical experts in predicting acute kidney injury following paediatric cardiopulmonary bypass. PG - 20847 LID - 10.1038/s41598-025-04651-8 [doi] LID - 20847 AB - The emergence of large language models (LLMs) opens new horizons to leverage, often unused, information in clinical text. Our study aims to capitalise on this new potential. Specifically, we examine the utility of text embeddings generated by LLMs in predicting postoperative acute kidney injury (AKI) in paediatric cardiopulmonary bypass (CPB) patients using electronic health record (EHR) text, and propose methods for explaining their output. AKI could be a serious complication in paediatric CPB and its accurate prediction can significantly improve patient outcomes by enabling timely interventions. We evaluate various text embedding algorithms such as Doc2Vec, top-performing sentence transformers on Hugging Face, and commercial LLMs from Google and OpenAI. We benchmark the cross-validated performance of these 'AI models' against a 'baseline model' as well as an established clinically-defined 'expert model'. The baseline model includes structured features, i.e., patient gender, age, height, body mass index and length of operation. The majority of AI models surpass, not only the baseline model, but also the expert model. An ensemble of AI and clinical-expert models improves discriminative performance by 23% compared to the baseline model. Consistency of patient clusters formed from AI-generated embeddings with clinical-expert clusters-measured via the adjusted rand index and adjusted mutual information metrics-illustrates the medical validity of LLM embeddings. We create a reverse mapping from the numeric embedding space to the natural-language domain via the embedding-based clusters, generating medical labels for the clusters in the process. We also use text-generating LLMs to summarise the differences between AI and expert clusters. Such 'explainability' outputs can increase medical practitioners' trust in the AI applications, and help generate new hypotheses, e.g., by studying the association of cluster memberships and outcomes of interest. CI - (c) 2025. The Author(s). FAU - Sharabiani, Mansour AU - Sharabiani M AD - School of Public Health, Imperial College London, London, UK. mt5605@imperial.ac.uk. FAU - Mahani, Alireza AU - Mahani A AD - New York Stock Exchange, New York, United States. alireza.s.mahani@gmail.com. FAU - Bottle, Alex AU - Bottle A AD - School of Public Health, Imperial College London, London, UK. FAU - Srinivasan, Yadav AU - Srinivasan Y AD - Great Ormond Street Hospital, London, UK. FAU - Issitt, Richard AU - Issitt R AD - Great Ormond Street Hospital, London, UK. FAU - Stoica, Serban AU - Stoica S AD - Bristol Royal Hospital for Children, Bristol, UK. LA - eng PT - Journal Article DEP - 20250701 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Acute Kidney Injury/etiology/diagnosis MH - *Cardiopulmonary Bypass/adverse effects MH - Child MH - Male MH - Female MH - Electronic Health Records MH - Child, Preschool MH - Algorithms MH - Infant MH - *Postoperative Complications/etiology/diagnosis PMC - PMC12216426 OTO - NOTNLM OT - Acute kidney injury OT - Cardiopulmonary bypass OT - Electronic health records OT - Generative artificial intelligence OT - Spherical k-means OT - Text embedding COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/07/02 06:29 MHDA- 2025/07/02 06:30 PMCR- 2025/07/01 CRDT- 2025/07/02 00:31 PHST- 2024/11/01 00:00 [received] PHST- 2025/05/28 00:00 [accepted] PHST- 2025/07/02 06:30 [medline] PHST- 2025/07/02 06:29 [pubmed] PHST- 2025/07/02 00:31 [entrez] PHST- 2025/07/01 00:00 [pmc-release] AID - 10.1038/s41598-025-04651-8 [pii] AID - 4651 [pii] AID - 10.1038/s41598-025-04651-8 [doi] PST - epublish SO - Sci Rep. 2025 Jul 1;15(1):20847. doi: 10.1038/s41598-025-04651-8. PMID- 40593781 OWN - NLM STAT- MEDLINE DCOM- 20250702 LR - 20250704 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Jul 2 TI - Potential utility of the triglyceride-glucose index as a predictor of erectile dysfunction and its severity: a cross-sectional, case-control study. PG - 23078 LID - 10.1038/s41598-025-02458-1 [doi] LID - 23078 AB - The aim of this case-control study was to evaluate the relationship between triglyceride-glucose index (TyG Index) and erectile dysfunction (ED) and its severity. A total of 230 male patients, aged between 18 and 75 years, admitted to the urology outpatient clinic with complaining erectile dysfunction were evaluated. Routine blood serum tests performed to determine the etiology of ED were analyzed. TyG index was calculated. All patients were requested to fill in the validated Turkish version of the 5-item International Index of erectile function (IIEF-5) survey. ED severity of patients was determined according to IIEF-5 scores and data of patients with and without ED were compared. The ED group exhibited higher values for body mass index, waist circumference, fasting blood glucose, ALT, and triglycerides compared to the control group (p < 0.05). In contrast, AST and total testosterone levels were significantly lower in the ED group (p < 0.05). The TyG index was significantly higher, and IIEF scores were lower in the ED group (p < 0.05). Moreover, the TyG index was elevated across all ED subgroups (severe, moderate, mild-moderate, and mild) compared to the control group (p < 0.05). The TyG index demonstrated significant effectiveness in distinguishing severe ED from all other ED groups. Based on the results of our study, the TyG index appears to be a simple method that shows a high correlation with the severity of ED. We believe that the use of the TyG index in the diagnosis and follow-up of ED is noteworthy, and further prospective studies with larger sample sizes are needed to support this conclusion. CI - (c) 2025. The Author(s). FAU - Ates, Huseyin Aytac AU - Ates HA AUID- ORCID: 0000-0001-8908-4324 AD - Department of Urology, Istanbul Training and Research Hospital, Health Sciences University, 34100, Istanbul, Turkey. h.aytacates@gmail.com. FAU - Bulut, Taha Burak AU - Bulut TB AUID- ORCID: 0009-0003-0586-7340 AD - Department of Urology, Istanbul Training and Research Hospital, Health Sciences University, 34100, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20250702 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Triglycerides) RN - 0 (Blood Glucose) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Male MH - *Erectile Dysfunction/blood/diagnosis MH - Middle Aged MH - Adult MH - Case-Control Studies MH - *Triglycerides/blood MH - *Blood Glucose/analysis/metabolism MH - Aged MH - Cross-Sectional Studies MH - Severity of Illness Index MH - Young Adult MH - Adolescent MH - Body Mass Index MH - Biomarkers/blood PMC - PMC12219019 OTO - NOTNLM OT - Erectile dysfunction OT - Insuline resistance OT - Metabolic syndrome OT - Triglyceride-glucose index COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/07/02 06:28 MHDA- 2025/07/02 06:29 PMCR- 2025/07/02 CRDT- 2025/07/02 00:22 PHST- 2025/02/06 00:00 [received] PHST- 2025/05/13 00:00 [accepted] PHST- 2025/07/02 06:29 [medline] PHST- 2025/07/02 06:28 [pubmed] PHST- 2025/07/02 00:22 [entrez] PHST- 2025/07/02 00:00 [pmc-release] AID - 10.1038/s41598-025-02458-1 [pii] AID - 2458 [pii] AID - 10.1038/s41598-025-02458-1 [doi] PST - epublish SO - Sci Rep. 2025 Jul 2;15(1):23078. doi: 10.1038/s41598-025-02458-1. PMID- 40593400 OWN - NLM STAT- MEDLINE DCOM- 20251113 LR - 20260616 IS - 1531-135X (Electronic) IS - 1530-7026 (Print) IS - 1530-7026 (Linking) VI - 25 IP - 6 DP - 2025 Dec TI - Sleepiness but neither fluid nor crystallized intelligence can be predicted from resting-state electroencephalography - Evidence from the large scale CoScience EEG-Personality Project. PG - 1737-1750 LID - 10.3758/s13415-025-01323-y [doi] AB - Previous electroencephalogram (EEG) studies linked measures of spectral power under rest and fluid intelligence; however, subsequent high-powered studies challenged this relationship. The present study aimed to address previous limitations (low statistical power, lack of preregistration) and investigated the predictability of intelligence measures from resting-state EEG in the CoScience data set (N = 772). Support vector regressions were applied to analyze 8 min of resting-state EEG with eyes open and closed before and after unrelated tasks. The decoding performance between the spectral power of 59 EEG channels within 30 frequency bins and fluid and crystallized intelligence, was evaluated with a tenfold cross-validation. We could not identify any meaningful associations between resting-state EEG spectral power and either fluid or crystallized intelligence-a null finding that is unlikely to be entirely due to a relatively modest restriction of fluid intelligence variance in our student sample. Moreover, we did replicate the previously reported association between state sleepiness and theta power, attesting to the integrity of the CoScience data set. Furthermore, the decomposition of the EEG signal into its periodic and aperiodic components revealed that the aperiodic offset parameter is significantly correlated with state sleepiness, emphasizing the relevance of aperiodic signal components in understanding states of alertness versus sleepiness. CI - (c) 2025. The Author(s). FAU - Fruehlinger, Christoph AU - Fruehlinger C AUID- ORCID: 0000-0001-5901-9206 AD - Department of Differential Psychology and Psychological Assessment, Institute of Psychology, University of Hamburg, Von-Melle-Park-5, 20146, Hamburg, Germany. c.fruehlinger@gmail.com. FAU - Paul, Katharina AU - Paul K AUID- ORCID: 0000-0001-9817-740X AD - Department of Differential Psychology and Psychological Assessment, Institute of Psychology, University of Hamburg, Von-Melle-Park-5, 20146, Hamburg, Germany. FAU - Kuhrt, Corinna AU - Kuhrt C AUID- ORCID: 0000-0002-6418-6479 AD - Faculty of Psychology, Technische Universitat Dresden, Zellescher Weg 17, 01069, Dresden, Germany. FAU - Wacker, Jan AU - Wacker J AUID- ORCID: 0000-0001-8627-7294 AD - Department of Differential Psychology and Psychological Assessment, Institute of Psychology, University of Hamburg, Von-Melle-Park-5, 20146, Hamburg, Germany. LA - eng GR - BE 2443/12-1/Deutsche Forschungsgemeinschaft/ GR - HE 2443/16-1/Deutsche Forschungsgemeinschaft/ GR - HE 5330/15-1/Deutsche Forschungsgemeinschaft/ GR - HI 1780/6-1/Deutsche Forschungsgemeinschaft/ GR - MU 3535/7-1/Deutsche Forschungsgemeinschaft/ GR - OS 422/7-1/Deutsche Forschungsgemeinschaft/ GR - PA 4014/2-2/Deutsche Forschungsgemeinschaft/ GR - STA 1035/6-1/Deutsche Forschungsgemeinschaft/ GR - STR 615/7-1/Deutsche Forschungsgemeinschaft/ GR - WA 2593/9-1/Deutsche Forschungsgemeinschaft/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250701 PL - United States TA - Cogn Affect Behav Neurosci JT - Cognitive, affective & behavioral neuroscience JID - 101083946 SB - IM MH - Humans MH - *Electroencephalography MH - Male MH - Female MH - *Intelligence/physiology MH - Young Adult MH - Adult MH - *Sleepiness/physiology MH - *Brain/physiology MH - Adolescent MH - Rest/physiology PMC - PMC12615557 OTO - NOTNLM OT - Intelligence OT - MVPA OT - Personality neuroscience OT - Resting-state electroencephalography OT - Sleepiness COIS- Declarations. Conflict of interests: The authors have no relevant financial or non-financial interests to disclose. Ethics approval: The study protocol of the CoScience data set was approved by the ethics committee of the German Society of Psychology (DGPs). Consent to participate: All participants provided informed consent to participate (Paul et al., 2022b). Consent for publication: Not applicable. Open Practices: This study was preregistered before accessing the data ( https://doi.org/ https://doi.org/10.17605/OSF.IO/JB64Z ). We have minor deviations from our preregistration to disclose (i.e., exploratory cluster analysis, number of Spearman correlations between average spectral power and sleepiness scores; see Table 2 in the Appendix; Willroth & Atherton, 2024). EDAT- 2025/07/02 06:28 MHDA- 2025/11/14 00:27 PMCR- 2025/07/01 CRDT- 2025/07/02 00:06 PHST- 2025/06/05 00:00 [accepted] PHST- 2025/11/14 00:27 [medline] PHST- 2025/07/02 06:28 [pubmed] PHST- 2025/07/02 00:06 [entrez] PHST- 2025/07/01 00:00 [pmc-release] AID - 10.3758/s13415-025-01323-y [pii] AID - 1323 [pii] AID - 10.3758/s13415-025-01323-y [doi] PST - ppublish SO - Cogn Affect Behav Neurosci. 2025 Dec;25(6):1737-1750. doi: 10.3758/s13415-025-01323-y. Epub 2025 Jul 1. PMID- 40591533 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260603 IS - 2767-3375 (Electronic) IS - 2767-3375 (Linking) VI - 5 IP - 7 DP - 2025 TI - Systematic review of risk assessment tools for post-discharge mortality among children in sub-Saharan Africa. PG - e0004788 LID - 10.1371/journal.pgph.0004788 [doi] LID - e0004788 AB - Post-discharge mortality is increasingly recognized as a major contributor to the high burden of childhood mortality in sub-Saharan Africa. Accurate identification of children at risk for post-discharge mortality is critically important to inform interventions to reduce deaths following hospital discharge. Our objective was to describe the current state of development, validation, or implementation for risk assessment tools for post-hospital discharge mortality (PDM) in sub-Saharan Africa. We conducted a systematic review of publications on risk assessment tools for PDM among children aged 0-18 years in sub-Saharan Africa. We searched CABI Global Health, Cochrane Reviews, Cochrane Trials, ProQuest Dissertations and Theses, Embase, PubMed, and Web of Science with no date or language restriction. We included publications if they described a tool/model with weights assigned to variables to quantify risk of PDM, included children, and were conducted in sub-Saharan Africa. We determined the level of evidence for tools using the Evidence-Based-Medicine Working Group hierarchy. Of 4,893 publications screened, 289 full texts were reviewed, and seven publications that reported 23 risk assessment tools for PDM among children in sub-Saharan Africa were identified. These studies enrolled 49,669 total participants (3.6%, n = 1,795 experienced PDM). There was substantial heterogeneity in identified risk factors, although all identified malnutrition as a risk factor for PDM. All risk assessment tools had fair (i.e., area under the receiver operating characteristic curve [AUC] >/=0.70) or good (AUC >/= 0.80) discriminatory value in internal validation. Only two risk assessment tools had been externally validated, and none were implemented. Existing risk assessment tools to identify children at risk for PDM in sub-Saharan Africa lack broad validation and implementation. Malnutrition is a common risk factor for PDM. Further studies are needed to validate and implement such tools to reduce PDM among children. CI - Copyright: (c) 2025 Ginjupalli et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Ginjupalli, Ramya AU - Ginjupalli R AUID- ORCID: 0009-0005-8891-5911 AD - Emory University School of Medicine, Atlanta, Georgia, United States of America. FAU - Cole, Kaitlin AU - Cole K AD - Emory University School of Medicine, Atlanta, Georgia, United States of America. FAU - Manji, Karim P AU - Manji KP AUID- ORCID: 0000-0002-7069-6408 AD - Department of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Kisenge, Rodrick AU - Kisenge R AD - Department of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Rogers, Hannah AU - Rogers H AUID- ORCID: 0000-0002-9515-1439 AD - Woodruff Health Sciences Center Library, Emory University, Atlanta, Georgia, United States of America. FAU - Westbrook, Adrianna AU - Westbrook A AUID- ORCID: 0000-0001-9309-6205 AD - Pediatric Biostatistics Core, Department of Pediatrics, Emory University, Atlanta, Georgia, United States of America. FAU - Bassat, Quique AU - Bassat Q AUID- ORCID: 0000-0003-0875-7596 AD - ISGlobal, Barcelona, Spain. AD - Centro de Investigacao em Saude de Manhica [CISM], Maputo, Mozambique. AD - ICREA, Pg. Lluis Companys 23, Barcelona, Spain. AD - Institut Clinic de Medicina I Dermatologia, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Facultat de Medicina i Ciencies de la Salut, Universitat de Barcelona (UB), Barcelona, Spain. AD - Pediatrics Department, Hospital Sant Joan de Deu, Universitat de Barcelona, Esplugues, Barcelona, Spain. AD - CIBER de Epidemiologia y Salud Publica, Instituto de Salud Carlos III, Madrid, Spain. FAU - Varo, Rosauro AU - Varo R AUID- ORCID: 0000-0003-4282-5572 AD - ISGlobal, Barcelona, Spain. AD - Centro de Investigacao em Saude de Manhica [CISM], Maputo, Mozambique. FAU - Madrid, Lola AU - Madrid L AD - London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom. AD - College of Health and Medical Sciences, Harar, Haramaya University, Ethiopia. FAU - Mandomando, Inacio AU - Mandomando I AUID- ORCID: 0000-0002-1078-2187 AD - ISGlobal, Barcelona, Spain. AD - Centro de Investigacao em Saude de Manhica [CISM], Maputo, Mozambique. FAU - Morris, Claudia R AU - Morris CR AUID- ORCID: 0000-0001-6019-2858 AD - Division of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America. AD - Department of Emergency Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia, United States of America. FAU - Assefa, Nega AU - Assefa N AUID- ORCID: 0000-0003-0341-2329 AD - London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom. AD - College of Health and Medical Sciences, Harar, Haramaya University, Ethiopia. FAU - Omore, Richard AU - Omore R AUID- ORCID: 0000-0003-3702-3030 AD - Kenya Medical Research Institute-Center for Global Health Research, Kisumu, Kenya. FAU - Akelo, Victor AU - Akelo V AD - Liverpool School of Tropical Medicine, United Kingdom, Kenya. FAU - Igunza, Kitiezo Aggrey AU - Igunza KA AD - Kenya Medical Research Institute-Center for Global Health Research, Kisumu, Kenya. FAU - Duggan, Christopher P AU - Duggan CP AD - Departments of Nutrition and Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America. AD - Center for Nutrition, Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts, United States of America. FAU - Rees, Chris A AU - Rees CA AD - Division of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America. AD - Department of Emergency Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia, United States of America. LA - eng GR - K24 AT009893/AT/NCCIH NIH HHS/United States PT - Journal Article DEP - 20250701 PL - United States TA - PLOS Glob Public Health JT - PLOS global public health JID - 9918283779606676 PMC - PMC12212496 COIS- The authors have declared that no competing interests exist. EDAT- 2025/07/01 21:17 MHDA- 2025/07/01 21:18 PMCR- 2025/07/01 CRDT- 2025/07/01 13:32 PHST- 2025/02/06 00:00 [received] PHST- 2025/05/26 00:00 [accepted] PHST- 2025/07/01 21:18 [medline] PHST- 2025/07/01 21:17 [pubmed] PHST- 2025/07/01 13:32 [entrez] PHST- 2025/07/01 00:00 [pmc-release] AID - PGPH-D-25-00323 [pii] AID - 10.1371/journal.pgph.0004788 [doi] PST - epublish SO - PLOS Glob Public Health. 2025 Jul 1;5(7):e0004788. doi: 10.1371/journal.pgph.0004788. eCollection 2025. PMID- 40588896 OWN - NLM STAT- MEDLINE DCOM- 20250701 LR - 20250701 IS - 1879-8365 (Electronic) IS - 0926-9630 (Linking) VI - 328 DP - 2025 Jun 26 TI - Enhanced Machine Learning Approach to ADHD Classification Using Actigraphy Data. PG - 136-140 LID - 10.3233/SHTI250688 [doi] AB - Attention Deficit Hyperactivity Disorder (ADHD) diagnosis remains challenging due to its heterogeneous presentation and reliance on subjective assessments. This study investigates the potential of actigraphy data combined with advanced machine learning techniques to classify ADHD status. We collected daily activity data from 45 participants (23 with ADHD, 22 without ADHD) from the OBF-Psychiatric dataset and extracted novel features capturing temporal patterns, activity transitions, and circadian rhythm characteristics. Multiple classification models were evaluated, with Support Vector Machines achieving the best performance (F1 score: 0.779). Feature importance analysis revealed that day-night activity transitions, activity burst rates, and established clinical scales were the most predictive indicators. Despite the modest cohort, actigraphy successfully classified ADHD and revealed promising candidate biomarkers, providing valuable insights that establish a foundation for further validation in larger studies. FAU - Feretzakis, Georgios AU - Feretzakis G AD - School of Science and Technology, Hellenic Open University, Patras, Greece. FAU - Boufeas, Iris AU - Boufeas I AD - The London School of Medicine and Dentistry, Queen Mary University of London, 64 Turner Street, London E1 2AD, UK. FAU - Fotakidis, Sophia AU - Fotakidis S AD - St. Catherine's British School in Athens, Greece. FAU - Bazakidou, Efrosyni AU - Bazakidou E AD - Medical School, Humanitas University, 20072 Milan, Italy. FAU - Kalodanis, Konstantinos AU - Kalodanis K AD - Harokopio University of Athens, Kallithea, Greece. FAU - Peristera, Paraskevi AU - Peristera P AD - Division of Psychobiology and Epidemiology, Department of Psychology, 10691 Stockholm, Sweden. FAU - Anastasiou, Athanasios AU - Anastasiou A AD - Biomedical Engineering Laboratory, National Technical University of Athens, Athens, Greece. LA - eng PT - Journal Article PL - Netherlands TA - Stud Health Technol Inform JT - Studies in health technology and informatics JID - 9214582 SB - IM MH - Humans MH - *Actigraphy/methods MH - *Attention Deficit Disorder with Hyperactivity/diagnosis/classification/physiopathology MH - *Machine Learning MH - Male MH - Female MH - Support Vector Machine MH - Child MH - *Diagnosis, Computer-Assisted/methods MH - Adolescent OTO - NOTNLM OT - ADHD Classification OT - Clinical Decision Support OT - Machine learning EDAT- 2025/07/01 09:31 MHDA- 2025/07/01 09:32 CRDT- 2025/07/01 01:03 PHST- 2025/07/01 09:32 [medline] PHST- 2025/07/01 09:31 [pubmed] PHST- 2025/07/01 01:03 [entrez] AID - SHTI250688 [pii] AID - 10.3233/SHTI250688 [doi] PST - ppublish SO - Stud Health Technol Inform. 2025 Jun 26;328:136-140. doi: 10.3233/SHTI250688. PMID- 40587244 OWN - NLM STAT- MEDLINE DCOM- 20251031 LR - 20260626 IS - 2325-6621 (Electronic) IS - 2325-6621 (Linking) VI - 22 IP - 11 DP - 2025 Nov TI - Ultra-Low Dose Thoracic Computed Tomography-derived Morphomics in Patients with Cystic Fibrosis on Elexacaftor/Tezacaftor/Ivacaftor. PG - 1680-1687 LID - 10.1513/AnnalsATS.202411-1151OC [doi] AB - Rationale: In cystic fibrosis (CF), body composition alterations are observed. The prevalence of obesity in CF is increasing, with evidence suggesting a subsequent increase in cardiometabolic risk. We sought to assess body composition using analytic morphomics from ultra-low-dose thoracic computed tomography (CT) scans in patients with CF on the triple CFTR (cystic fibrosis transmembrane conductance regulator) modulator therapy elexacaftor/tezacaftor/ivacaftor (ETI). Objectives: Our objective was to use analytical morphomics on routine ultra-low-dose CTs to assess patterns of change in body composition in patients with CF on ETI therapy. Methods: Forty-two patients with CF on ETI who had baseline and follow-up ultra-low-dose thoracic CT imaging were retrospectively analyzed. The CTs were acquired at a radiation dose equivalent to two frontal chest X-rays using our previously published acquisition parameters. The Bhalla score was used as a marker of structural lung disease severity. Analytic morphomics variables, including cross-sectional area and attenuation of pectoralis muscle, visceral fat (epicardial and upper abdominal), and subcutaneous fat, were extracted using the validated image segmentation software CoreSlicer. Paired-samples mean testing (Wilcoxon matched-pairs signed-rank test) and Spearman rank correlation analyses were performed. Results: Total Bhalla scores significantly improved over time in patients on ETI (P < 0.0001). In addition, body composition also changed, with an increase in the cross-sectional area of subcutaneous and epicardial visceral fat (P < 0.0001 and P = 0.0062, respectively). In those with a normal BMI at follow-up, epicardial and subcutaneous fat had also increased significantly in the interval (P = 0.0066 and P = 0.0002, respectively). Conclusions: In CF, ETI produced a significant improvement in structural lung disease over time; however, it also resulted in an increase in visceral and subcutaneous fat. The analytic morphomics methodology presented herein may help identify those patients for aggressive primary prevention strategies and permit the creation of more personalized nutritional plans. FAU - O'Regan, Patrick W AU - O'Regan PW AUID- ORCID: 0009-0002-8868-1375 AD - Department of Radiology. AD - Department of Radiology at the School of Medicine. FAU - Ibrahim, Hisham I S AU - Ibrahim HIS AD - Cork Centre for Cystic Fibrosis (3CF), and. AD - The Health Research Board Clinical Research Facility, Cork University Hospital, University College Cork, Cork, Ireland. AD - Department of Medicine, University College Cork, Cork, Ireland. FAU - Blackburn, Sean AU - Blackburn S AUID- ORCID: 0009-0005-6442-2231 AD - Department of Radiology. FAU - O'Mahony, Alexander T AU - O'Mahony AT AUID- ORCID: 0000-0001-9110-2579 AD - Department of Radiology. FAU - Waldron, Michael G AU - Waldron MG AUID- ORCID: 0000-0002-4073-9841 AD - Department of Radiology. FAU - Shet, Sahil S AU - Shet SS AUID- ORCID: 0000-0003-3104-7234 AD - Department of Radiology at the School of Medicine. FAU - Deasy, Kevin F AU - Deasy KF AD - Cork Centre for Cystic Fibrosis (3CF), and. FAU - Plant, Barry J AU - Plant BJ AUID- ORCID: 0000-0002-4611-6768 AD - Cork Centre for Cystic Fibrosis (3CF), and. AD - The Health Research Board Clinical Research Facility, Cork University Hospital, University College Cork, Cork, Ireland. AD - Department of Medicine, University College Cork, Cork, Ireland. FAU - Ryan, David J AU - Ryan DJ AD - Department of Radiology. AD - Department of Radiology at the School of Medicine. FAU - Maher, Michael M AU - Maher MM AUID- ORCID: 0000-0001-7423-7439 AD - Department of Radiology. AD - Department of Radiology at the School of Medicine. LA - eng PT - Journal Article PL - England TA - Ann Am Thorac Soc JT - Annals of the American Thoracic Society JID - 101600811 RN - 0 (Aminophenols) RN - 0 (Quinolones) RN - 0 (Benzodioxoles) RN - 0 (Drug Combinations) RN - 0 (Indoles) RN - 0 (Pyridines) RN - 0 (Pyrazoles) RN - 0 (Chloride Channel Agonists) SB - IM MH - Humans MH - *Cystic Fibrosis/drug therapy/diagnostic imaging MH - Female MH - Male MH - Retrospective Studies MH - *Aminophenols/therapeutic use MH - *Quinolones/therapeutic use MH - *Benzodioxoles/therapeutic use MH - Drug Combinations MH - *Tomography, X-Ray Computed/methods MH - Adult MH - *Body Composition MH - Young Adult MH - *Indoles/therapeutic use MH - Adolescent MH - *Pyridines/therapeutic use MH - *Pyrazoles/therapeutic use MH - Chloride Channel Agonists/therapeutic use OTO - NOTNLM OT - X-ray computed OT - computer-assisted OT - cystic fibrosis OT - image interpretation OT - tomography EDAT- 2025/07/01 04:45 MHDA- 2025/10/31 17:30 CRDT- 2025/06/30 12:13 PHST- 2025/10/31 17:30 [medline] PHST- 2025/07/01 04:45 [pubmed] PHST- 2025/06/30 12:13 [entrez] AID - 10.1513/AnnalsATS.202411-1151OC [doi] PST - ppublish SO - Ann Am Thorac Soc. 2025 Nov;22(11):1680-1687. doi: 10.1513/AnnalsATS.202411-1151OC. PMID- 40586408 OWN - NLM STAT- MEDLINE DCOM- 20250630 LR - 20250711 IS - 2299-8306 (Electronic) IS - 0423-104X (Linking) VI - 76 IP - 3 DP - 2025 TI - Normalization strategies in neonatal steroid metabolomics: a comparative analysis of probabilistic quotient and peer group approaches. PG - 331-338 LID - 10.5603/ep.106090 [doi] AB - INTRODUCTION: Steroid metabolomics in neonatal populations is challenged by considerable physiological heterogeneity and technical variability, which complicate the interpretation and comparability of metabolite profiles. Effective normalization strategies are essential to ensure accurate data analysis in this context. MATERIAL AND METHODS: We analyzed 24-hour urinary steroid profiles in a cohort of 50 neonates (including very preterm, late preterm, and full-term infants) using gas chromatography-mass spectrometry. Two normalization techniques were compared: probabilistic quotient normalization (PQN) and peer group normalization (PGN). Normalization performance was assessed via distribution metrics, correlation with anthropometric variables, and principal component analysis (PCA). RESULTS: PGN achieved superior distributional normalization, with 27 of 30 metabolites conforming to normality assumptions, compared to 21 using PQN. PGN also eliminated all significant correlations between steroid levels and anthropometric parameters, indicating effective reduction of physiological confounding. In contrast, PQN partially mitigated such associations but was less robust in handling high-abundance metabolites. PCA confirmed improved sample dispersion and group separation after normalization, with method-dependent differences in Scores Plot. CONCLUSIONS: Peer group normalization is a sophisticated approach to reducing physiological variability in neonatal steroid profiling. These observations lend further credence to PGN as a promising strategy for standardizing steroid metabolomics in the field of neonatology. Nevertheless, further validation is necessary to substantiate these findings. FAU - Lorek, Milosz AU - Lorek M AUID- ORCID: 0000-0002-5276-9247 AD - Department of Neonatal and Pediatric Intensive Care, John Paul II Center for Child and Family Health, Sosnowiec, Poland. lorek.milosz@gmail.com. AD - Department of Pediatrics and Pediatric Endocrinology, Medical University of Silesia, Katowice, Poland. lorek.milosz@gmail.com. FAU - Stradomska, Teresa Joanna AU - Stradomska TJ AUID- ORCID: 0000-0002-5585-413X AD - Laboratory for the Diagnosis of Metabolic Disorders and Steroidogenesis, The Children's Memorial Health Institute, Warsaw, Poland. FAU - Siejka, Anna AU - Siejka A AUID- ORCID: 0000-0001-7179-7713 AD - Laboratory for the Diagnosis of Metabolic Disorders and Steroidogenesis, The Children's Memorial Health Institute, Warsaw, Poland. FAU - Fuchs, Janusz AU - Fuchs J AUID- ORCID: 0009-0006-6925-6831 AD - Department of Neonatal and Pediatric Intensive Care, John Paul II Center for Child and Family Health, Sosnowiec, Poland. FAU - Janus, Dominika AU - Janus D AUID- ORCID: 0000-0002-3870-368X AD - Department of Pediatric and Adolescent Endocrinology, Jagiellonian University Medical College, University Children's Hospital, Krakow, Poland. FAU - Gawlik-Starzyk, Aneta AU - Gawlik-Starzyk A AUID- ORCID: 0000-0002-9309-4741 AD - Department of Pediatrics and Pediatric Endocrinology, Medical University of Silesia, Katowice, Poland. LA - eng PT - Comparative Study PT - Journal Article PL - Poland TA - Endokrynol Pol JT - Endokrynologia Polska JID - 0370674 RN - 0 (Steroids) SB - IM MH - Humans MH - Infant, Newborn MH - *Metabolomics/methods MH - *Steroids/urine/metabolism MH - Female MH - Male MH - Gas Chromatography-Mass Spectrometry MH - Infant, Premature/urine MH - Principal Component Analysis OTO - NOTNLM OT - metabolomics OT - neonates OT - normalization OT - steroidogenesis EDAT- 2025/07/01 04:07 MHDA- 2025/07/01 04:08 CRDT- 2025/06/30 08:23 PHST- 2025/05/02 00:00 [received] PHST- 2025/06/09 00:00 [accepted] PHST- 2025/06/09 00:00 [revised] PHST- 2025/07/01 04:08 [medline] PHST- 2025/07/01 04:07 [pubmed] PHST- 2025/06/30 08:23 [entrez] AID - VM/OJS/J/106090 [pii] AID - 10.5603/ep.106090 [doi] PST - ppublish SO - Endokrynol Pol. 2025;76(3):331-338. doi: 10.5603/ep.106090. PMID- 40585342 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250702 IS - 2666-6677 (Electronic) IS - 2666-6677 (Linking) VI - 23 DP - 2025 Sep TI - Enhanced oral glucose tolerance test for early detection of insulin resistance and metabolic complications in children with obesity. PG - 101016 LID - 10.1016/j.ajpc.2025.101016 [doi] LID - 101016 AB - BACKGROUND AND AIMS: Early detection of insulin resistance (IR) and obesity-related complications is crucial for preventing type 2 diabetes. This study aimed to identify dynamic metabolic biomarkers for more precise early detection of IR and metabolic abnormalities. METHODS: This cross-sectional cohort study evaluated IR and metabolic biomarkers in 403 children with obesity (median age 13.18 years, 51.3 % female, 98.5 % with obesity) using an enhanced oral glucose tolerance test (eOGTT). IR was assessed via four indices, with the Matsuda Insulin Sensitivity Index (ISI-M) used as the primary measure. Participants were stratified into quartiles based on ISI-M. RESULTS: Participants with the highest IR (Q1) were older (p = 0.002), had a higher body mass index, were in a more advanced pubertal stage (p < 0.001), and had significantly elevated glucose and insulin levels (p < 0.001 for both) compared to the most insulin sensitive (Q4), with significant differences observed across all quartiles (p < 0.050 for all). Insulin at 120 min demonstrated excellent diagnostic accuracy for IR (AUC=0.958). Triglyceride levels in Q1 showed minimal decline during the eOGTT, while greater declines were observed with increasing insulin sensitivity (p = 0.002 across quartiles), suggesting that a lack of decline in triglycerides may help identify IR. High-sensitivity C-reactive protein levels increased with IR (p = 0.024). Baseline beta-hydroxybutyrate levels were highest in the Q4 and showed the greatest absolute decrease during the eOGTT, compared to Q1 (p < 0.001 for both). CONCLUSIONS: We validated established IR markers in children with obesity, while demonstrating that eOGTT may offer improved characterization and earlier identification of those at risk for metabolic complications. CI - (c) 2025 The Author(s). FAU - Groselj, Urh AU - Groselj U AD - Department of Endocrinology, Diabetes, and Metabolic Diseases, University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia. AD - Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. FAU - Kafol, Jan AU - Kafol J AD - Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. AD - Department of Vascular Diseases, Division of Internal Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia. FAU - Sikonja, Jaka AU - Sikonja J AD - Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. AD - Department of Endocrinology, Diabetes and Metabolic Diseases, Division of Internal Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia. FAU - Mlinaric, Matej AU - Mlinaric M AD - Department of Endocrinology, Diabetes, and Metabolic Diseases, University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia. AD - Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. FAU - Sket, Robert AU - Sket R AD - Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. AD - Clinical Institute of Special Laboratory Diagnostics, University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia. FAU - Remec, Ziga Iztok AU - Remec ZI AD - Clinical Institute of Special Laboratory Diagnostics, University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia. FAU - Kovac, Jernej AU - Kovac J AD - Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. AD - Clinical Institute of Special Laboratory Diagnostics, University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia. FAU - Drole Torkar, Ana AU - Drole Torkar A AD - Department of Endocrinology, Diabetes, and Metabolic Diseases, University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia. AD - Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. FAU - Suput Omladic, Jasna AU - Suput Omladic J AD - Department of Endocrinology, Diabetes, and Metabolic Diseases, University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia. AD - Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. FAU - Repic Lampret, Barbka AU - Repic Lampret B AD - Clinical Institute of Special Laboratory Diagnostics, University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia. FAU - Battelino, Tadej AU - Battelino T AD - Department of Endocrinology, Diabetes, and Metabolic Diseases, University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia. AD - Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. FAU - Kotnik, Primoz AU - Kotnik P AD - Department of Endocrinology, Diabetes, and Metabolic Diseases, University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia. AD - Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. LA - eng PT - Journal Article DEP - 20250604 PL - Netherlands TA - Am J Prev Cardiol JT - American journal of preventive cardiology JID - 101769122 PMC - PMC12205605 OTO - NOTNLM OT - Adolescents OT - Children OT - Insulin resistance OT - Metabolic complications OT - OGTT OT - Obesity OT - Oral glucose tolerance test OT - Screening COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/07/01 04:06 MHDA- 2025/07/01 04:07 PMCR- 2025/06/04 CRDT- 2025/06/30 06:23 PHST- 2025/02/16 00:00 [received] PHST- 2025/05/18 00:00 [revised] PHST- 2025/05/29 00:00 [accepted] PHST- 2025/07/01 04:07 [medline] PHST- 2025/07/01 04:06 [pubmed] PHST- 2025/06/30 06:23 [entrez] PHST- 2025/06/04 00:00 [pmc-release] AID - S2666-6677(25)00091-1 [pii] AID - 101016 [pii] AID - 10.1016/j.ajpc.2025.101016 [doi] PST - epublish SO - Am J Prev Cardiol. 2025 Jun 4;23:101016. doi: 10.1016/j.ajpc.2025.101016. eCollection 2025 Sep. PMID- 40582871 OWN - NLM STAT- MEDLINE DCOM- 20250629 LR - 20260127 IS - 1881-7742 (Electronic) IS - 0301-4800 (Linking) VI - 71 IP - 3 DP - 2025 TI - Association between the Frequency of the Combined Staple, Main, and Side Dishes Examined Using a Validated Questionnaire and the Intake of Nutrients and Food Groups among Young and Middle-Aged Japanese Adults: Results from the DOSANCO Health Study: A Cross-Sectional Study. PG - 201-210 LID - 10.3177/jnsv.71.201 [doi] AB - To clarify the association between the intake frequency of a meal combination of staple, main, and side dishes (SMS meal), determined using a validated questionnaire, and the intake of various nutrients and food groups among Japanese adults. In this cross-sectional study, we analyzed data from 936 persons aged 18-64 y who participated in the Dynamics of Lifestyle and Neighborhood Community on Health Study. The intake frequency of SMS meals was assessed using our validated questionnaire and validated. The intake of nutrients and food groups was examined using validated food-frequency questionnaires. To examine the association of the intake frequency of SMS meals with the intake of specific nutrients and food groups, linear regression analysis was conducted with adjustment for age, body mass index, education history, living status (alone or not), smoking status, and alcohol drinking. The intake frequency of SMS meals was significantly positively associated with the intake of 24/32 nutrients in men, 8/32 nutrients in women, 6/16 food groups in men, and 1/16 food groups in women, and significantly negatively associated with 2/16 food groups in men. A higher intake frequency of SMS meals was not significantly associated with a higher intake of salt or saturated fats. Our results suggest that a higher intake frequency of SMS meals, examined using a validated questionnaire, may be associated with a higher intake of certain nutrients and food groups among young and middle-aged adults without a higher intake of salt and saturated fats. FAU - Yaegashi, Akinori AU - Yaegashi A AD - Graduate School of Medicine, Hokkaido University. AD - Department of Health and Nutrition, Faculty of Human Science, Hokkaido Bunkyo University. AD - Department of Nutrition, Faculty of Health and Welfare, Takasaki University of Health and Welfare. FAU - Okada, Emiko AU - Okada E AD - The Health Care Science Institute. FAU - Kimura, Takashi AU - Kimura T AD - Faculty of Medicine, Hokkaido University. FAU - Nakamura, Koshi AU - Nakamura K AD - Department of Public Health and Epidemiology, Graduate School of Medicine, University of the Ryukyus. FAU - Ukawa, Shigekazu AU - Ukawa S AD - Osaka Metropolitan University Graduate School of Human Life and Ecology. FAU - Nakagawa, Takafumi AU - Nakagawa T AD - The Hokkaido Centre for Family Medicine. FAU - Imae, Akihiro AU - Imae A AD - Suttu Municipal Suttu Clinic. FAU - Matsushita, Mami AU - Matsushita M AD - Graduate School of Nursing and Nutrition, Tenshi College. FAU - Minegishi, Yukiko AU - Minegishi Y AD - Graduate School of Nursing and Nutrition, Tenshi College. FAU - Momose, Izumi AU - Momose I AD - Graduate School of Nursing and Nutrition, Tenshi College. AD - Faculty of School of Health Sciences, Sapporo University of Health Sciences. FAU - Shimizu, Mari AU - Shimizu M AD - Graduate School of Nursing and Nutrition, Tenshi College. FAU - Suzuki, Junko AU - Suzuki J AD - Graduate School of Nursing and Nutrition, Tenshi College. FAU - Kubo, Chizuru AU - Kubo C AD - Graduate School of Nursing and Nutrition, Tenshi College. FAU - Yamaguchi, Atsuko AU - Yamaguchi A AD - Graduate School of Nursing and Nutrition, Tenshi College. FAU - Musashi, Manabu AU - Musashi M AD - Graduate School of Nursing and Nutrition, Tenshi College. FAU - Ohkubo, Iwao AU - Ohkubo I AD - Graduate School of Nursing and Nutrition, Tenshi College. FAU - Tamakoshi, Akiko AU - Tamakoshi A AD - Faculty of Medicine, Hokkaido University. LA - eng PT - Journal Article PL - Japan TA - J Nutr Sci Vitaminol (Tokyo) JT - Journal of nutritional science and vitaminology JID - 0402640 RN - 0 (Nutrients) RN - Japanese people SB - IM MH - Humans MH - Adult MH - Male MH - Female MH - Cross-Sectional Studies MH - Middle Aged MH - Japan MH - Young Adult MH - Surveys and Questionnaires MH - Adolescent MH - *Diet MH - *Nutrients/administration & dosage MH - *Feeding Behavior MH - *Meals MH - Body Mass Index MH - Diet Surveys MH - East Asian People OTO - NOTNLM OT - Japanese OT - foods OT - nutrients OT - questionnaire OT - "staple food, main dish, and side dish" EDAT- 2025/07/01 04:06 MHDA- 2025/07/01 04:07 CRDT- 2025/06/29 21:43 PHST- 2025/07/01 04:07 [medline] PHST- 2025/07/01 04:06 [pubmed] PHST- 2025/06/29 21:43 [entrez] AID - 10.3177/jnsv.71.201 [doi] PST - ppublish SO - J Nutr Sci Vitaminol (Tokyo). 2025;71(3):201-210. doi: 10.3177/jnsv.71.201. PMID- 40582390 OWN - NLM STAT- MEDLINE DCOM- 20260124 LR - 20260124 IS - 1542-7714 (Electronic) IS - 1542-3565 (Linking) VI - 24 IP - 2 DP - 2026 Feb TI - Optimal Cutoffs of Fatty Liver Index and Hepatic Steatosis Index in Diagnosing Pediatric Metabolic Dysfunction-associated Steatotic Liver Disease. PG - 421-431.e6 LID - S1542-3565(25)00530-0 [pii] LID - 10.1016/j.cgh.2025.06.011 [doi] AB - BACKGROUND & AIMS: Despite the high global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), effective noninvasive diagnostic tools in pediatric populations remain limited. We aimed to validate the predictive performance of the fatty liver index (FLI) and hepatic steatosis index (HSI) in diagnosing MASLD in the young population and propose optimal cutoff points for the diagnosis of MASLD and severe MASLD. METHODS: This cross-sectional study included data from 1158 and 203 youths from the United States National Health and Nutrition Examination Survey (NHANES) 2017 to 2020 and real-world clinical environments, respectively. Hepatic steatosis was defined based on controlled attenuation parameter values obtained from vibration-controlled transient elastography or ultrasonography. The performances of the FLI and HSI were evaluated using logistic regression, the area under the receiver operating characteristic curve (AUC), and optimal cutoffs determined via Youden's index. RESULTS: The AUCs of FLI and HSI for MASLD were 0.91 and 0.90 in the NHANES data, respectively, and 0.93 for both indices in real-world clinical data. The optimal cutoffs for MASLD diagnosis were 20 (lower) and 50 (upper) for the FLI and 30 (lower) and 40 (upper) for the HSI. For severe MASLD, the FLI cutoff increased to 60, whereas the HSI cutoff remained at 40, with both achieving AUCs of 0.83. In youth with normal alanine aminotransferase levels, the AUCs of both indices were 0.89 in the NHANES and 0.91 in real-world clinical data. CONCLUSIONS: FLI and HSI are effective noninvasive tools for diagnosing pediatric MASLD and severe MASLD, including in youth with normal alanine aminotransferase levels. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Song, Kyungchul AU - Song K AD - Department of Pediatrics, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Republic of Korea. FAU - Kwon, Yu-Jin AU - Kwon YJ AD - Department of Family Medicine, Yonsei University College of Medicine, Yongin Severance Hospital, Yongin-si, Republic of Korea. FAU - Lee, Eunju AU - Lee E AD - Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Lee, Hye Sun AU - Lee HS AD - Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Youn, Young Hoon AU - Youn YH AD - Department of Healthcare Research Team, Health Promotion Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Baik, Su Jung AU - Baik SJ AD - Department of Healthcare Research Team, Health Promotion Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Shin, Hyun Joo AU - Shin HJ AD - Department of Radiology, Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, Republic of Korea. FAU - Chae, Hyun Wook AU - Chae HW AD - Department of Pediatrics, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Republic of Korea. Electronic address: hopechae@yuhs.ac. LA - eng PT - Journal Article DEP - 20250627 PL - United States TA - Clin Gastroenterol Hepatol JT - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association JID - 101160775 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Female MH - Child MH - Adolescent MH - *Fatty Liver/diagnosis/pathology MH - Nutrition Surveys MH - United States MH - ROC Curve MH - Elasticity Imaging Techniques MH - Severity of Illness Index MH - Ultrasonography MH - Child, Preschool OTO - NOTNLM OT - Adolescent OT - Biomarkers OT - Child OT - Fatty Liver OT - Metabolic Dysfunction-associated Steatotic Liver Disease EDAT- 2025/07/01 04:06 MHDA- 2026/01/24 12:31 CRDT- 2025/06/29 19:11 PHST- 2025/01/30 00:00 [received] PHST- 2025/06/09 00:00 [revised] PHST- 2025/06/09 00:00 [accepted] PHST- 2026/01/24 12:31 [medline] PHST- 2025/07/01 04:06 [pubmed] PHST- 2025/06/29 19:11 [entrez] AID - S1542-3565(25)00530-0 [pii] AID - 10.1016/j.cgh.2025.06.011 [doi] PST - ppublish SO - Clin Gastroenterol Hepatol. 2026 Feb;24(2):421-431.e6. doi: 10.1016/j.cgh.2025.06.011. Epub 2025 Jun 27. PMID- 40581940 OWN - NLM STAT- MEDLINE DCOM- 20250811 LR - 20250811 IS - 1466-447X (Electronic) IS - 0264-0414 (Linking) VI - 43 IP - 18 DP - 2025 Sep TI - Agreement between numerical integration techniques during countermovement jumps with accentuated eccentric loading in youth athletes. PG - 1952-1966 LID - 10.1080/02640414.2025.2526297 [doi] AB - This study evaluated agreement between a) force platform numerical integration techniques for calculating performance variables and b) three-dimensional (3D) motion capture and vertical ground reaction force (vGRF) methods for identifying the dumbbell release during countermovement jumps with accentuated eccentric loading (CMJ(AEL)). Twenty adolescent participants (10 males, 10 females) performed CMJ(AEL) with handheld dumbbells at 20%, 25% and 30% of body mass. Variables were compared across five integration methods using repeated measures Bland-Altman and two-way repeated measures ANOVA analyses (alpha = 0.05), with combined forward and backward integration serving as the criterion. Backward integration and after adjusting at the dumbbells release agreed with the criterion, while forward integration and adjusting at the bottom position did not. The dumbbell release point identified using 3D motion capture (criterion) was also compared to estimates derived from force platform data (vGRF method). The vGRF method identified the dumbbell release point in delay of 3D motion capture, with limits of agreement (LOA) between -0.17 and 0.03 s across conditions. These methods should not be used interchangeably; rather, we recommend that the vGRF method be used in situations whereby only force platforms are available, and that it is combined with forward and backward integration techniques. FAU - Bright, Thomas E AU - Bright TE AUID- ORCID: 0000-0001-8089-817X AD - Youth Physical Development Centre, Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK. AD - School of Sport, Exercise and Rehabilitation, Plymouth Marjon University, Plymouth, UK. FAU - Lake, Jason AU - Lake J AD - Institute of Sport, Nursing, and Allied Health, University of Chichester, Chichester, UK. FAU - Harry, John R AU - Harry JR AD - Human Performance & Biomechanics Laboratory, Department of Kinesiology & Sport Management, Texas Tech University, Lubbock, Texas, USA. FAU - Hite, Mia AU - Hite M AD - Human Performance & Biomechanics Laboratory, Department of Kinesiology & Sport Management, Texas Tech University, Lubbock, Texas, USA. FAU - Simms, Anton AU - Simms A AD - Human Performance & Biomechanics Laboratory, Department of Kinesiology & Sport Management, Texas Tech University, Lubbock, Texas, USA. FAU - Theis, Nicola AU - Theis N AD - School of Sport and Exercise, University of Gloucestershire, Gloucester, UK. FAU - Mundy, Peter AU - Mundy P AD - Hawkin Dynamics, Inc., Westbrook, Maine, USA. FAU - Hughes, Jonathan D AU - Hughes JD AD - Youth Physical Development Centre, Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK. LA - eng PT - Journal Article DEP - 20250629 PL - England TA - J Sports Sci JT - Journal of sports sciences JID - 8405364 SB - IM MH - Humans MH - Male MH - Adolescent MH - Female MH - Biomechanical Phenomena MH - *Plyometric Exercise/methods MH - *Athletic Performance/physiology MH - Time and Motion Studies MH - *Exercise Test/methods OTO - NOTNLM OT - Numerical integration OT - accentuated eccentric loading OT - eccentric training OT - jumping OT - youth athlete EDAT- 2025/07/01 04:06 MHDA- 2025/08/11 06:27 CRDT- 2025/06/29 13:12 PHST- 2025/08/11 06:27 [medline] PHST- 2025/07/01 04:06 [pubmed] PHST- 2025/06/29 13:12 [entrez] AID - 10.1080/02640414.2025.2526297 [doi] PST - ppublish SO - J Sports Sci. 2025 Sep;43(18):1952-1966. doi: 10.1080/02640414.2025.2526297. Epub 2025 Jun 29. PMID- 40580653 OWN - NLM STAT- MEDLINE DCOM- 20250711 LR - 20260812 IS - 1879-1360 (Electronic) IS - 0022-3999 (Linking) VI - 195 DP - 2025 Aug TI - Validation of the weight self-stigma questionnaire in a polish sample: Factor structure and measurement invariance by gender. PG - 112186 LID - S0022-3999(25)00150-3 [pii] LID - 10.1016/j.jpsychores.2025.112186 [doi] AB - BACKGROUND: This cross-sectional study aimed to confirm the factorial structure of the Polish Weight Self-Stigma Questionnaire (WSSQ) and to test structural validity, internal consistency and measurement invariance of the questionnaire across gender, Body Mass Index (BMI) and other psychological measures. METHODS: The sample was recruited from the general Polish population (N = 1055), age 18-55. Participants completed the WSSQ, The Yale Food Addiction Scale (YFAS 2.0), Emotional Eating and Restrained Eating subscales from The Dutch Eating Behavior Questionnaire (DEBQ), The Depression, Anxiety and Stress Scale - 21 (DASS-21) and sociodemographic survey. RESULTS: The Polish WSSQ showed good overlap with the original structure in the two-factor model (Self-devaluation and Fear of Enacted Stigma). Factor loadings were satisfactory and both subscales showed good internal consistency. The scale demonstrated metric, but not scalar, measurement invariance by gender. The construct validity was confirmed with strong correlations with emotional eating and food addiction. As expected, the WSSQ total score was moderately positively associated with depression and stress severity. The correlations were the weakest for restrained eating and body mass index. CONCLUSION: The Polish WSSQ is a valid and reliable tool for the assessment of weight-related self-stigma among patients with overweight/obesity. Men and women can be compared when examining association of WSSQ with other measures but gender differences on the WSSQ itself should be interpreted with caution. Future studies should further investigate potential gender differences as well as the test-retest reliability and longitudinal invariance. CI - Copyright (c) 2025 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Rozycka, Jagoda AU - Rozycka J AD - Institute of Psychology, University of Silesia, Katowice, Poland. FAU - Nowacki, Ari AU - Nowacki A AD - Institute of Psychology, University of Silesia, Katowice, Poland. FAU - Lukowska, Marta AU - Lukowska M AD - Institute of Psychology, University of Silesia, Katowice, Poland; Emotion Cognition Lab, Institute of Psychology, SWPS University, Katowice, Poland. FAU - Sokolowska, Maryla AU - Sokolowska M AD - Institute of Psychology, University of Silesia, Katowice, Poland. FAU - Zielinska, Joanna AU - Zielinska J AD - Institute of Psychology, University of Silesia, Katowice, Poland; Medical University of Silesia, Katowice, Poland. FAU - Duszkiewicz, Roksana AU - Duszkiewicz R AD - Faculty of Medicine, Academy of Silesia, Katowice, Poland. FAU - Stojek, Monika M AU - Stojek MM AD - Institute of Psychology, University of Silesia, Katowice, Poland; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: monika.stojek@us.edu.pl. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250614 PL - England TA - J Psychosom Res JT - Journal of psychosomatic research JID - 0376333 SB - IM MH - Humans MH - Male MH - Adult MH - Female MH - Poland MH - Middle Aged MH - Surveys and Questionnaires/standards MH - Young Adult MH - Cross-Sectional Studies MH - Adolescent MH - Reproducibility of Results MH - Body Mass Index MH - *Social Stigma MH - Sex Factors MH - *Self Concept MH - *Body Weight MH - Factor Analysis, Statistical MH - Feeding Behavior/psychology MH - Psychometrics OTO - NOTNLM OT - Confirmatory factor analysis OT - Mental health OT - Obesity OT - Psychological assessment OT - Weight self-stigma COIS- Declaration of competing interest The authors declare no competing financial interests. Monika Stojek reports financial support was provided by University of Silesia. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper EDAT- 2025/07/01 04:47 MHDA- 2025/07/12 16:44 CRDT- 2025/06/28 18:03 PHST- 2024/12/02 00:00 [received] PHST- 2025/05/16 00:00 [revised] PHST- 2025/06/13 00:00 [accepted] PHST- 2025/07/12 16:44 [medline] PHST- 2025/07/01 04:47 [pubmed] PHST- 2025/06/28 18:03 [entrez] AID - S0022-3999(25)00150-3 [pii] AID - 10.1016/j.jpsychores.2025.112186 [doi] PST - ppublish SO - J Psychosom Res. 2025 Aug;195:112186. doi: 10.1016/j.jpsychores.2025.112186. Epub 2025 Jun 14. PMID- 40580104 OWN - NLM STAT- MEDLINE DCOM- 20250628 LR - 20260910 IS - 1365-2060 (Electronic) IS - 0785-3890 (Print) IS - 0785-3890 (Linking) VI - 57 IP - 1 DP - 2025 Dec TI - Development and validation of an improved prediction model for vaginal birth after previous cesarean section: a retrospective cohort study of a Chinese population. PG - 2523617 LID - 10.1080/07853890.2025.2523617 [doi] LID - 2523617 AB - OBJECTIVE: The transition from one-child to two-child and three-child policy in China has increasingly led to a rise in the number of women who choose trial of labor after cesarean section (TOLAC). Achieving vaginal birth after cesarean section (VBAC) is, however, not always guaranteed, and a failed TOLAC is associated with a high risk of maternal and neonatal complications. Although Grobman's model may help predict VBAC, variations in population characteristics and healthcare settings can limit its generalizability and validity on a global scale. This study, therefore, seeks to develop and validate an improved prediction model for VBAC at the onset of labor among the Chinese population. METHODS: Seven hundred and twenty women who attempted a TOLAC were enrolled. The development dataset comprised 481 women, while the other 239 women constituted the temporal validation dataset. Variable selection was executed using the least absolute shrinkage and selection operator method. Model development was performed using logistic regression techniques and was presented as a nomogram. RESULTS: Of the participants, 81.4% achieved VBAC. The model included maternal age, maternal height, ratio of weight gain to pre-pregnancy weight, interval time of pregnancies, previous vaginal delivery, premature rupture of membranes, oxytocin administration, spontaneous labor onset, labor analgesia, and newborn weight. The development and temporally validated areas under the curve were 0.780 (95% confidence interval 0.726-0.834) and 0.774 (95% confidence interval 0.694-0.854), respectively. Internal validation performed by bootstrap resampling, calibration curves, and Hosmer-Lemeshow test confirmed the model's robust performance. An optimal predicted probability cut-off of 0.7 was identified by decision curve analysis and clinical considerations. CONCLUSIONS: The improved predictive VBAC model exhibited adequate performance such that women with a prior low transverse cesarean delivery who scored 0.7 or higher (in the model-derived probability score) would consider TOLAC, potentially leading to a reduction in maternal-neonatal morbidity. REGISTRATION: The study was approved by the Ethical Committee of Obstetrics and Gynecology Hospital, Fudan University (2018-43) and was registered in the Chinese Clinical Trial Registry (ChiCTR1900022484), https://www.chictr.org.cn/showproj.html?proj=37898. The study adhered to the Declaration of Helsinki. The first participant was enrolled on January 1, 2016. The requirement for informed consent was waived because the data were anonymized. FAU - Liu, Haiyan AU - Liu H AUID- ORCID: 0000-0002-3812-7520 AD - Department of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. FAU - Yu, Yi AU - Yu Y AD - Department of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. FAU - Zhang, Xiaoyue AU - Zhang X AD - Department of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. FAU - Pei, Jiangnan AU - Pei J AD - Department of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. FAU - Tang, Yao AU - Tang Y AD - Department of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. FAU - Hu, Rong AU - Hu R AD - Department of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. FAU - Gu, Weirong AU - Gu W AUID- ORCID: 0000-0002-2157-0454 AD - Department of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250628 PL - England TA - Ann Med JT - Annals of medicine JID - 8906388 RN - 50-56-6 (Oxytocin) RN - Chinese people SB - IM MH - Humans MH - Female MH - *Vaginal Birth after Cesarean/statistics & numerical data MH - Pregnancy MH - Adult MH - Retrospective Studies MH - China/epidemiology MH - *Trial of Labor MH - Nomograms MH - Logistic Models MH - Maternal Age MH - Oxytocin MH - East Asian People PMC - PMC12207765 OAB - An improved prediction model that underwent both internal and temporal validation performed well for the Chinese VBAC in the adjustment of China's fertility policy setting.Pregnancy interval of more than 10 years became an unfavorable factor for VBAC.Predictors of the ratio of weight gain to pre-pregnancy weight marked a pivotal advancement in acknowledging the impact of pre-pregnancy obesity and judicious gestational weight management on the likelihood of achieving a VBAC. OABL- eng OTO - NOTNLM OT - Chinese population OT - Vaginal birth after cesarean OT - interval time of pregnancies OT - prediction model OT - ratio of weight gain to pre-pregnancy weight OT - temporal validation COIS- The authors declare no conflict of interest. EDAT- 2025/07/01 04:49 MHDA- 2025/07/01 04:50 PMCR- 2025/06/28 CRDT- 2025/06/28 09:12 PHST- 2025/07/01 04:50 [medline] PHST- 2025/07/01 04:49 [pubmed] PHST- 2025/06/28 09:12 [entrez] PHST- 2025/06/28 00:00 [pmc-release] AID - 2523617 [pii] AID - 10.1080/07853890.2025.2523617 [doi] PST - ppublish SO - Ann Med. 2025 Dec;57(1):2523617. doi: 10.1080/07853890.2025.2523617. Epub 2025 Jun 28. PMID- 40578884 OWN - NLM STAT- MEDLINE DCOM- 20250627 LR - 20250707 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 6 DP - 2025 Jun 26 TI - Vitamin D levels and its influencing factors in children and adolescents in mainland China: a systematic review and meta-analysis. PG - e094693 LID - 10.1136/bmjopen-2024-094693 [doi] LID - e094693 AB - OBJECTIVES: Childhood vitamin D deficiency is a public health issue. This study aims to systematically evaluate vitamin D nutritional status among children and adolescents in Mainland China through a quantitative analysis of literature, providing evidence-based strategies for prevention. DESIGN: This is a systematic review and meta-analysis, conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. DATA SOURCES: A comprehensive search strategy was implemented across eight electronic databases (PubMed, Embase, Web of Science, Cochrane Library, CNKI, VIP, Wanfang and CBM) from inception to February 2024. ELIGIBILITY CRITERIA: We included cross-sectional studies that measured serum 25-hydroxyvitamin D levels and analysed influencing factors (eg, age, season, region) in healthy children and adolescents aged 0-18 years in Mainland China; studies reporting prevalence data of vitamin D deficiency/insufficiency based on standardised thresholds (deficiency <50 nmol/L, insufficiency 50-75 nmol/L) and using validated detection methods (eg, liquid chromatography-tandem mass spectrometry, chemiluminescence immunoassay, ELISA) were prioritised. DATA EXTRACTION AND SYNTHESIS: Two independent reviewers systematically searched, screened and extracted data using predefined protocols. Study quality was assessed with the Agency for Healthcare Research and Quality (AHRQ) tool. Meta-analyses were performed using random-effects models in Review Manager V.5.3 and Stata V.16.0, with subgroup analyses by age, season and region. Sensitivity analysis and Egger's test were applied to evaluate robustness and publication bias. Findings were synthesised through narrative summaries and quantitative pooling. RESULTS: The pooled prevalence of vitamin D deficiency among children and adolescents in Mainland China was 48% (95% CI: 40% to 57%), with extreme heterogeneity across studies (I(2) = 99.98%, p<0.001). Sensitivity analysis confirmed the stability of pooled estimates. Subgroup analyses revealed significant age-related declines (infants: 82.35 nmol/L vs adolescents: 50.98 nmol/L, p<0.05). Study quality assessed by AHRQ criteria showed 16% of included studies were high-quality (scores 8-11/11), 84% moderate (4-7). Evidence of publication bias was detected via Egger's test (p<0.05) and funnel plot asymmetry. CONCLUSIONS: The study highlights the widespread nature of vitamin D deficiency among children and adolescents in Mainland China, particularly in older children and during winter months. Effective interventions are necessary to address this issue. Future research should prioritise methodological standardisation to reduce heterogeneity and address potential publication bias. PROSPERO REGISTRATION NUMBER: CRD42023479183. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Ji, Pengyun AU - Ji P AD - Department of Pain, Eastern Theater General Hospital, Nanjing, Jiangsu, China. FAU - Li, Zisheng AU - Li Z AD - Department of Nuclear Medicine, Chaohu Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Qin, Wenyan AU - Qin W AD - Department of Nuclear Medicine, Chaohu Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - She, Youqing AU - She Y AD - Department of Nuclear Medicine, Chaohu Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Chen, Bo AU - Chen B AUID- ORCID: 0000-0002-7233-4531 AD - Department of Nuclear Medicine, Chaohu Hospital of Anhui Medical University, Hefei, Anhui, China 584526014@qq.com. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20250626 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) SB - IM MH - Humans MH - Child MH - Adolescent MH - China/epidemiology MH - *Vitamin D Deficiency/epidemiology/blood MH - *Vitamin D/blood/analogs & derivatives MH - Child, Preschool MH - Infant MH - Nutritional Status MH - Infant, Newborn MH - Seasons MH - Cross-Sectional Studies MH - Prevalence PMC - PMC12207136 OTO - NOTNLM OT - Adolescents OT - China OT - Meta-Analysis COIS- Competing interests: None declared. EDAT- 2025/06/28 00:39 MHDA- 2025/06/28 00:40 PMCR- 2025/06/26 CRDT- 2025/06/27 20:33 PHST- 2025/06/28 00:40 [medline] PHST- 2025/06/28 00:39 [pubmed] PHST- 2025/06/27 20:33 [entrez] PHST- 2025/06/26 00:00 [pmc-release] AID - bmjopen-2024-094693 [pii] AID - 10.1136/bmjopen-2024-094693 [doi] PST - epublish SO - BMJ Open. 2025 Jun 26;15(6):e094693. doi: 10.1136/bmjopen-2024-094693. PMID- 40578560 OWN - NLM STAT- MEDLINE DCOM- 20250821 LR - 20250822 IS - 2156-5376 (Electronic) IS - 2161-8313 (Print) IS - 2161-8313 (Linking) VI - 16 IP - 8 DP - 2025 Aug TI - Perspective: Growth Monitoring and Promotion as an Opportunity to Improve Early Childhood Development. PG - 100470 LID - S2161-8313(25)00106-1 [pii] LID - 10.1016/j.advnut.2025.100470 [doi] LID - 100470 AB - Growth monitoring and promotion (GMP) visits provide a frequent contact point with caregivers, which can be an opportunity for the promotion of early child development (ECD). Using a combination of quantitative analyses of longitudinal and cross-sectional data and a review of the literature, we investigated whether the GMP platform could improve ECD by identifying children at risk of poor development and delivering responsive parenting education to caregivers of young children. Cross-sectional and lagged regression analyses and area under the receiver operating characteristic curves indicated that growth indices were not accurate predictors of concurrent and later child development. Rather, validated tools, such as the Ages and Stages Questionnaire or the Survey of Well-being of Young Children, could be utilized during GMP visits to screen individual children for suboptimal development. Through a review of published literature on ECD interventions, we identified 10 light-touch ECD interventions that could feasibly be implemented during GMP visits, but only half have been evaluated for their effectiveness. Our findings demonstrate that, although growth indices cannot accurately identify children at risk of suboptimal development, the GMP platform could offer an opportunity to screen children for suboptimal development and to deliver ECD interventions. Further evidence on the implementation and effectiveness of light-touch parenting programs, however, is required. CI - Copyright (c) 2025 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Larson, Leila M AU - Larson LM AD - Department of Health Promotion, Education, and Behavior, University of South Carolina, SC, United States. Electronic address: Larsonl@mailbox.sc.edu. FAU - Frongillo, Edward A AU - Frongillo EA AD - Department of Health Promotion, Education, and Behavior, University of South Carolina, SC, United States. FAU - Akter, Fahmida AU - Akter F AD - Department of Health Promotion, Education, and Behavior, University of South Carolina, SC, United States. FAU - Wooten, Shelbie AU - Wooten S AD - Department of Health Promotion, Education, and Behavior, University of South Carolina, SC, United States. FAU - Brander, Rebecca L AU - Brander RL AD - International Food Policy Research Institute, Washington, DC, United States. FAU - Ruel, Marie T AU - Ruel MT AD - International Food Policy Research Institute, Washington, DC, United States. FAU - Leroy, Jef L AU - Leroy JL AD - International Food Policy Research Institute, Washington, DC, United States. LA - eng PT - Journal Article PT - Review DEP - 20250625 PL - United States TA - Adv Nutr JT - Advances in nutrition (Bethesda, Md.) JID - 101540874 SB - IM MH - Humans MH - *Child Development MH - Child, Preschool MH - Parenting MH - Infant MH - *Health Promotion/methods MH - Cross-Sectional Studies MH - Female MH - Male MH - Longitudinal Studies MH - Surveys and Questionnaires MH - Caregivers/education PMC - PMC12296435 OTO - NOTNLM OT - early childhood development OT - epidemiology OT - growth monitoring and promotion OT - psychosocial stimulation OT - screening OT - stunting COIS- Conflict of interest JLL reports financial support was provided by Bill and Melinda Gates Foundation. Other authors declare they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/06/28 00:39 MHDA- 2025/09/08 08:03 PMCR- 2025/06/25 CRDT- 2025/06/27 19:14 PHST- 2025/05/20 00:00 [received] PHST- 2025/06/18 00:00 [revised] PHST- 2025/06/23 00:00 [accepted] PHST- 2025/09/08 08:03 [medline] PHST- 2025/06/28 00:39 [pubmed] PHST- 2025/06/27 19:14 [entrez] PHST- 2025/06/25 00:00 [pmc-release] AID - S2161-8313(25)00106-1 [pii] AID - 100470 [pii] AID - 10.1016/j.advnut.2025.100470 [doi] PST - ppublish SO - Adv Nutr. 2025 Aug;16(8):100470. doi: 10.1016/j.advnut.2025.100470. Epub 2025 Jun 25. PMID- 40578375 OWN - NLM STAT- MEDLINE DCOM- 20250710 LR - 20261028 IS - 2352-4650 (Electronic) IS - 2352-4642 (Linking) VI - 9 IP - 8 DP - 2025 Aug TI - Long-term kidney outcomes in children and adolescents with hypertension: a propensity-matched cohort study. PG - 553-564 LID - S2352-4642(25)00127-0 [pii] LID - 10.1016/S2352-4642(25)00127-0 [doi] AB - BACKGROUND: Hypertension affects 6% of all children and adolescents, is increasing in prevalence, and is associated with adverse cardiovascular outcomes. In childhood chronic kidney disease, hypertension is associated with progression to kidney failure. However, direct evidence linking childhood hypertension with long-term adverse kidney outcomes is scarce. We aimed to determine the long-term risk of major adverse kidney events (MAKEs) among children and adolescents diagnosed with hypertension. METHODS: In this population-based retrospective cohort study, we assessed data from all children and adolescents (aged 3-18 years) diagnosed with hypertension from April 1, 1996, to March 31, 2023, in Ontario, Canada, using validated case definitions in health administrative databases. Each case was propensity score-matched with up to five controls without hypertension by age, sex, birthweight, maternal gestational hypertension, pre-existing diabetes, previous cardiovascular surgery, obesity, previous acute kidney injury, and a propensity score for hypertension diagnosis. The primary outcome was major adverse kidney events (MAKEs; ie, all-cause mortality, incident chronic kidney disease, or kidney failure defined as start of chronic dialysis or receipt of kidney transplantation), assessed using weighted Cox regression using robust variance estimators to estimate hazard ratios (HRs) and 95% CIs. FINDINGS: 26 324 children and adolescents with hypertension were matched with 126 834 controls without hypertension, who were balanced on baseline covariates by propensity score matching. For children and adolescents with hypertension, median age at entry was 15 years (IQR 12-17), there were 10 868 (41.3%) females and 15 456 (58.7%) males, and previous personal and maternal comorbidities were uncommon (1169 [4.4%] had congenital heart disease, 1787 [6.8%] malignancy, 432 [1.6%] diabetes, 2356 [9.0%] complex chronic conditions, and 379 [3.0%] born to mothers with hypertension). During a median 14.2-year follow-up (IQR 7.4-20.7) in the hypertension cohort and 13.7-year follow-up (7.1-21.2) among controls, MAKE incidence was 5.52 per 1000 person-years (95% CI 5.28-5.76) in children and adolescents with hypertension versus 1.66 per 1000 person-years (1.60-1.72) in matched non-hypertensive controls (7.7% vs 2.4%; HR 3.03 [95% CI 2.86-3.21]). INTERPRETATION: Children and adolescents diagnosed with hypertension are at greater long-term risk of MAKEs compared with non-hypertensive controls. Improved recognition and control of paediatric hypertension might prevent progressive kidney dysfunction. These findings should be confirmed by large-scale, well-controlled prospective studies. FUNDING: Department of Pediatrics at McMaster University. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved, including those for text and data mining, AI training, and similar technologies. FAU - Hussain, Junayd AU - Hussain J AD - Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada. FAU - Georgieva, Kalina AU - Georgieva K AD - Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada. FAU - Robinson, Cal H AU - Robinson CH AD - Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada; Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada. FAU - Jeyakumar, Nivethika AU - Jeyakumar N AD - Lawson Health Research Institute and London Health Sciences Centre, London, ON, Canada; ICES (formerly the Institute for Clinical Evaluative Sciences), Hamilton, ON, Canada. FAU - Smith, Graham AU - Smith G AD - Lawson Health Research Institute and London Health Sciences Centre, London, ON, Canada; ICES (formerly the Institute for Clinical Evaluative Sciences), Hamilton, ON, Canada. FAU - Brady, Tammy AU - Brady T AD - Department of Pediatrics, Division of Nephrology, Johns Hopkins Children's Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. FAU - Dart, Allison AU - Dart A AD - Department of Pediatrics and Child Health, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada. FAU - Dionne, Janis AU - Dionne J AD - Department of Pediatrics, Division of Nephrology, University of British Columbia, Vancouver, BC, Canada. FAU - Karam, Sabine AU - Karam S AD - Division of Nephrology and Hypertension, Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Division of Nephrology and Hypertension, Department of Internal Medicine, American University of Beirut, Beirut, Lebanon. FAU - McKay, Ashlene M AU - McKay AM AD - Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada. FAU - Parekh, Rulan AU - Parekh R AD - Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada. FAU - Shroff, Rukshana AU - Shroff R AD - University College London Great Ormond Street Hospital, and Institute of Child Health, London, UK. FAU - Sinha, Manish D AU - Sinha MD AD - Department of Pediatric Nephrology, Evelina London Children's Hospital, Guy's & St Thomas' NHS Foundation Trust, London, UK; King's College London, London, UK. FAU - South, Andrew M AU - South AM AD - Department of Pediatrics, Atrium Health Levine Children's Hospital, Wake Forest University School of Medicine, Winston-Salem, NC, USA. FAU - Vincent, Carol AU - Vincent C AD - Department of Pediatrics, Atrium Health Levine Children's Hospital, Wake Forest University School of Medicine, Winston-Salem, NC, USA. FAU - Sood, Manish M AU - Sood MM AD - Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada. FAU - Chanchlani, Rahul AU - Chanchlani R AD - ICES (formerly the Institute for Clinical Evaluative Sciences), Hamilton, ON, Canada; Department of Pediatrics, McMaster University, Hamilton, ON, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada. Electronic address: chanchlr@mcmaster.ca. LA - eng GR - TL1 TR003136/TR/NCATS NIH HHS/United States PT - Journal Article DEP - 20250624 PL - England TA - Lancet Child Adolesc Health JT - The Lancet. Child & adolescent health JID - 101712925 SB - IM MH - Humans MH - Child MH - Adolescent MH - Female MH - Male MH - *Hypertension/complications/epidemiology MH - Retrospective Studies MH - Child, Preschool MH - Propensity Score MH - *Renal Insufficiency, Chronic/epidemiology/etiology MH - Ontario/epidemiology MH - Risk Factors COIS- Declaration of interests AMS received grant funding from the National Institutes of Health, as well as consulting fees from serving on the Advisory Board of IDORSIA Pharmaceuticals US, Kyowa Kirin, and Conjupro Biotherapeutics. AMS also serves on the AHA Council as a Committee Chair. All other authors declare no competing interests. EDAT- 2025/06/28 00:39 MHDA- 2025/07/11 00:26 CRDT- 2025/06/27 18:52 PHST- 2025/01/28 00:00 [received] PHST- 2025/04/09 00:00 [revised] PHST- 2025/04/15 00:00 [accepted] PHST- 2025/07/11 00:26 [medline] PHST- 2025/06/28 00:39 [pubmed] PHST- 2025/06/27 18:52 [entrez] AID - S2352-4642(25)00127-0 [pii] AID - 10.1016/S2352-4642(25)00127-0 [doi] PST - ppublish SO - Lancet Child Adolesc Health. 2025 Aug;9(8):553-564. doi: 10.1016/S2352-4642(25)00127-0. Epub 2025 Jun 24. PMID- 40576251 OWN - NLM STAT- MEDLINE DCOM- 20251004 LR - 20260825 IS - 1557-1246 (Electronic) IS - 1087-0547 (Print) IS - 1087-0547 (Linking) VI - 29 IP - 13 DP - 2025 Nov TI - Symptom and Performance Validity Measures in the Clinical Assessment of Adult ADHD: What Do We Learn from Network Analysis? PG - 1177-1189 LID - 10.1177/10870547251348779 [doi] AB - BACKGROUND: First-time diagnoses of attention-deficit/hyperactivity disorder (ADHD) in adults can be challenging due to diverse methodologies available for assessment, and the choices clinicians need to make about how to interpret diagnostic criteria. Network analysis is a statistical approach that has received growing attention in clinical research of recent years. It has the potential to aid visualization and illustrate the intricate relationships between the wide range of clinical measures. AIM: The goal of the present study is to examine the value of network analysis on a sample of N = 896 adults newly diagnosed with ADHD in an outpatient referral context. METHOD AND RESULTS: The network depicts the interrelationship of a comprehensive set of measures and test variables, including symptom self- and other-reports, cognitive tests, motor activity, as well as measures of symptom and performance validity. CONCLUSION: Our network analysis supports ADHD symptom clusters with distinct networks of motor activity and attention/impulsivity and reflects the mode of assessment, i.e., neuropsychological versus self- and observer-ratings. The network further depicts the dissociable role of symptom and performance validity measures, and the different nature of embedded and freestanding validity tests. We discuss the future application of network analysis in clinical research on ADHD. FAU - Fuermaier, Anselm B M AU - Fuermaier ABM AUID- ORCID: 0000-0002-2331-0840 AD - University of Groningen, The Netherlands. FAU - Hirsch, Oliver AU - Hirsch O AUID- ORCID: 0000-0003-4496-2554 AD - FOM University of Applied Sciences, Siegen, Germany. FAU - Albrecht, Bjorn AU - Albrecht B AUID- ORCID: 0000-0001-7936-2044 AD - Philipps University Marburg, Germany. FAU - Chavanon, Mira-Lynn AU - Chavanon ML AUID- ORCID: 0000-0003-1575-2486 AD - Philipps University Marburg, Germany. FAU - Christiansen, Hanna AU - Christiansen H AD - Philipps University Marburg, Germany. LA - eng PT - Journal Article DEP - 20250627 PL - United States TA - J Atten Disord JT - Journal of attention disorders JID - 9615686 SB - IM MH - Humans MH - *Attention Deficit Disorder with Hyperactivity/diagnosis/psychology MH - Adult MH - Male MH - Female MH - Neuropsychological Tests MH - Reproducibility of Results MH - Middle Aged MH - Young Adult MH - Motor Activity MH - Adolescent PMC - PMC12480614 OTO - NOTNLM OT - adult ADHD OT - network analysis OT - neuropsychological assessment OT - performance validity OT - symptom validity COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/06/27 12:29 MHDA- 2025/10/04 06:30 PMCR- 2025/09/30 CRDT- 2025/06/27 08:03 PHST- 2025/10/04 06:30 [medline] PHST- 2025/06/27 12:29 [pubmed] PHST- 2025/06/27 08:03 [entrez] PHST- 2025/09/30 00:00 [pmc-release] AID - 10.1177_10870547251348779 [pii] AID - 10.1177/10870547251348779 [doi] PST - ppublish SO - J Atten Disord. 2025 Nov;29(13):1177-1189. doi: 10.1177/10870547251348779. Epub 2025 Jun 27. PMID- 40575612 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250628 IS - 2169-7574 (Print) IS - 2169-7574 (Electronic) IS - 2169-7574 (Linking) VI - 13 IP - 6 DP - 2025 Jun TI - Complications and Satisfaction After Adolescent Breast Reduction for Juvenile Macromastia: Systematic Review and Meta-analysis. PG - e6913 LID - 10.1097/GOX.0000000000006913 [doi] LID - e6913 AB - BACKGROUND: Juvenile macromastia is a rare condition of significant breast enlargement in adolescents. Reduction mammoplasties offer relief, but data on complications in adolescents are rare as opposed to data on adults. We reviewed the outcomes, complications, recurrence, and patient satisfaction after reduction mammoplasties in adolescents. METHODS: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a thorough search across various electronic databases for "juvenile macromastia" and "breast reduction." Only studies on women diagnosed with juvenile macromastia before 21 years of age who underwent breast reduction surgery were included. The methodological index for nonrandomized studies was used to assess study quality. RESULTS: This meta-analysis pooled data from 11 studies. The overall pooled postoperative complication rate, based on random-effects models, was 17.5% (95% confidence interval: 9.7%-29.5%). The recurrence rate was 15.6% (95% confidence interval: 8.5%-26.9%), ranging from 0% to 52.9%. Complication rates varied widely across studies, with wound dehiscence, hematoma, and infection being the most common. Severe complications, such as nipple necrosis, were rare. Low publication bias was observed for postoperative complications, but potential bias was noted for recurrence outcomes. CONCLUSIONS: The findings emphasize the need for standardized reporting and long-term follow-up to improve the reliability of pooled estimates and to guide clinical decision-making. The high recurrence risk emphasized the need for individualized surgical approaches and careful management of risk factors, such as obesity and smoking, to improve outcomes. Despite the variability, the benefits of surgery generally outweighed the risks, with high patient satisfaction reported in the included studies. CI - Copyright (c) 2025 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons. FAU - Halawani, Ibrahim R AU - Halawani IR AD - From the College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Alalawi, Shahad AU - Alalawi S AD - Department of Plastic and Reconstructive Surgery, King Fahad General Hospital, Jeddah, Saudi Arabia. FAU - Alyamani, Sarah AU - Alyamani S AD - From the College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Alhithlool, Abdulmalek W AU - Alhithlool AW AD - College of Medicine, King Faisal University, Alhasa, Saudi Arabia. FAU - Ahmed, Ferdous A AU - Ahmed FA AD - From the College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Asali, Iraf AU - Asali I AD - Department of Plastic and Reconstructive Surgery, Alnoor Specialist Hospital, Makkah, Saudi Arabia. FAU - Alghamdi, Abdulrahman A AU - Alghamdi AA AD - Division of Plastic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada. FAU - Al Noman, Hatem AU - Al Noman H AD - Department of Plastic and Reconstructive Surgery, National Guard Hospital, Jeddah, Saudi Arabia. LA - eng PT - Journal Article DEP - 20250626 PL - United States TA - Plast Reconstr Surg Glob Open JT - Plastic and reconstructive surgery. Global open JID - 101622231 PMC - PMC12200214 COIS- The authors have no financial interest to declare in relation to the content of this article. EDAT- 2025/06/27 06:27 MHDA- 2025/06/27 06:28 PMCR- 2025/06/26 CRDT- 2025/06/27 04:57 PHST- 2023/11/25 00:00 [received] PHST- 2025/05/06 00:00 [accepted] PHST- 2025/06/27 06:28 [medline] PHST- 2025/06/27 06:27 [pubmed] PHST- 2025/06/27 04:57 [entrez] PHST- 2025/06/26 00:00 [pmc-release] AID - GOX-D-23-01068 [pii] AID - 10.1097/GOX.0000000000006913 [doi] PST - epublish SO - Plast Reconstr Surg Glob Open. 2025 Jun 26;13(6):e6913. doi: 10.1097/GOX.0000000000006913. eCollection 2025 Jun. PMID- 40575150 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250630 IS - 2772-5987 (Electronic) IS - 2772-5987 (Linking) VI - 5 IP - 2 DP - 2025 Jun TI - Maximum and minimum activity in inpatient adolescents with Bipolar Disorders: Daily-Variability classification of actigraphy pattern with artificial intelligence. LID - 100212 [pii] LID - 10.1016/j.psycom.2025.100212 [doi] AB - Measures of daily activity may be objective markers to help differentiate adolescent bipolar disorder (BD). We used chart reviewed actigraphy data collected from 2014 to 2023, and AI methods to classify well-characterized inpatient adolescents diagnosed with BD-without-attention deficit/hyperactivity disorder (ADHD), BD-with-ADHD, ADHD-without-BD, and other diagnoses (OD). 389 inpatient adolescents (232 female, mean age 15.07), wore an actigraphy monitor for the duration of their inpatient stay (mean number of unique days = 13.04 days). Activity was characterized into four 60-min maximum and minimum daily activity bins, automatically identified using a novel Python script. Feature engineering further described time-series data. 5193 days of data were split into training and testing sets. Random Forest and XGBoost models were trained with cross-validation on the training set and model metrics were compared. The best models were tested on the testing set. XGBoost with feature selection provided the most robust and balanced classification model. The most influential feature was the engineered difference between peak active hours, which along with other activity and age features classified all diagnostic groups with 91.5 % accuracy. Results indicated that daily activity levels, especially the variability between peak activity hours, showed potential for improving diagnostic precision in psychiatric settings. Actigraphy, combined with machine learning, offers a promising approach for classifying diagnostic groups among inpatient adolescent populations and engineered maximum and minimum hourly activity features may provide objective markers to improve diagnostic accuracy. Future studies should aim to test and validate these findings and assess their clinical implications in larger, diverse cohorts in the natural environment. FAU - Vahedifard, Farzan AU - Vahedifard F AD - Department of Psychiatry, University of Pittsburgh School of Medicine, USA. FAU - Birmaher, Boris AU - Birmaher B AD - Department of Psychiatry, University of Pittsburgh School of Medicine, USA. AD - UPMC Western Psychiatric Hospital, USA. FAU - Iyengar, Satish AU - Iyengar S AD - Department of Statistics, University of Pittsburgh, USA. FAU - Wolfe, Maria AU - Wolfe M AUID- ORCID: 0009-0002-9624-3615 AD - Department of Psychiatry, University of Pittsburgh School of Medicine, USA. FAU - Lepore, Brianna N AU - Lepore BN AD - Department of Psychiatry, University of Pittsburgh School of Medicine, USA. FAU - Chobany, Mariah AU - Chobany M AUID- ORCID: 0000-0003-3118-8432 AD - Department of Psychiatry, University of Pittsburgh School of Medicine, USA. FAU - Abdul-Waalee, Halimah AU - Abdul-Waalee H AD - Department of Psychiatry, University of Pittsburgh School of Medicine, USA. FAU - Malgireddy, Greeshma AU - Malgireddy G AD - Department of Psychiatry, University of Pittsburgh School of Medicine, USA. FAU - Hart, Jonathan A AU - Hart JA AD - Department of Psychiatry, University of Pittsburgh School of Medicine, USA. FAU - Bertocci, Michele A AU - Bertocci MA AUID- ORCID: 0000-0002-3857-1226 AD - Department of Psychiatry, University of Pittsburgh School of Medicine, USA. FAU - Diler, Rasim S AU - Diler RS AD - Department of Psychiatry, University of Pittsburgh School of Medicine, USA. AD - UPMC Western Psychiatric Hospital, USA. LA - eng GR - R01 MH121451/MH/NIMH NIH HHS/United States GR - S10 OD028483/OD/NIH HHS/United States PT - Journal Article DEP - 20250417 PL - Netherlands TA - Psychiatry Res Commun JT - Psychiatry research communications JID - 9918317688406676 PMC - PMC12199408 MID - NIHMS2090466 COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/06/27 06:27 MHDA- 2025/06/27 06:28 PMCR- 2025/06/26 CRDT- 2025/06/27 04:50 PHST- 2025/06/27 06:28 [medline] PHST- 2025/06/27 06:27 [pubmed] PHST- 2025/06/27 04:50 [entrez] PHST- 2025/06/26 00:00 [pmc-release] AID - 100212 [pii] AID - 10.1016/j.psycom.2025.100212 [doi] PST - ppublish SO - Psychiatry Res Commun. 2025 Jun;5(2):100212. doi: 10.1016/j.psycom.2025.100212. Epub 2025 Apr 17. PMID- 40574960 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250628 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 13 DP - 2025 TI - Assessment of mealtime behaviors in Chinese children with autism spectrum disorder. PG - 1597023 LID - 10.3389/fped.2025.1597023 [doi] LID - 1597023 AB - BACKGROUND: Children with autism often exhibit atypical eating behaviors, which may significantly impact their nutritional status and overall well-being. However, research on the dietary habits of Chinese children with autism remains limited. OBJECTIVE: This study primarily assesses the applicability of Brief Autism Mealtime Behavior Inventory (BAMBI) for Chinese children with autism, while further exploring the unique dietary behavior characteristics within this population. METHODS: In total, 103 children with autism aged 3-6 years and 331 typically developing preschoolers were recruited. All participants' parents completed the Brief Autism Mealtime Behavior Inventory (BAMBI) and the Six-item Gastrointestinal Severity Index (6-GSI). The reliability and validity of the Chinese version of the BAMBI were analyzed, and differences in dietary behavior were tested between cases and controls. RESULTS: The item reliability (Cronbach's alpha) was 0.849 for total BAMBI. Pearson correlation analyses of the full BAMBI scale scores and subscales revealed significant correlations (r values ranging from 0.580 to 0.912, P < 0.01). The confirmatory factor analysis result shows that BAMBI 18 items have an acceptable fit to the data (GFI = 0.901, CFI = 0.819, ILI = 0.821, RMSEA = 0.074). Although the value of average variance extra (AVE) of the main scale is slightly below 0.5, the composite reliability (CR) is both above 0.7. The ASD group scored significantly higher than the typically developing group in terms of the BAMBI total score and subscales. The top problematic dietary behaviors reported by parents were inflexible about mealtime routines (79.61%), unwilling to try new foods (75.73%) and not accepts or prefers a variety of foods (71.84%). The positive association between BAMBI total scores and 6-GSI scores was observed. CONCLUSION: BAMBI is a validated tool for assessing dietary behaviors in autistic children in China. Compared with their typically developing peers, ASD children presented more dietary behavior problems. This study emphasizes early attention to dietary behavior problems in children with autism. CI - (c) 2025 Zhang, Zhang, Peng, Chen, Zhang, Liang, Wang and Zhou. FAU - Zhang, Lili AU - Zhang L AD - Department of Pediatrics, Minhang Hospital, Fudan University, Shanghai, China. FAU - Zhang, Yunjian AU - Zhang Y AD - Department of Neurology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China. FAU - Peng, Zhongbi AU - Peng Z AD - Department of Neurological Rehabilitation, Guizhou Provincial People's Hospital, Medical College of Guizhou University, Guiyang, China. FAU - Chen, Yun AU - Chen Y AD - Department of Neurological Rehabilitation, Guizhou Provincial People's Hospital, Medical College of Guizhou University, Guiyang, China. FAU - Zhang, Lan AU - Zhang L AD - Child Health Care, Chengdu Women's and Children's Central Hospital, Chengdu, China. FAU - Liang, Lidan AU - Liang L AD - Department of Children's Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China. FAU - Wang, Yi AU - Wang Y AD - Department of Neurology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China. FAU - Zhou, Hao AU - Zhou H AD - Department of Rehabilitation, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China. LA - eng PT - Journal Article DEP - 20250612 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC12198228 OTO - NOTNLM OT - autism spectrum disorder OT - brief autism mealtime behavior inventory OT - dietary behavior OT - gastrointestinal problem OT - reliability and validity COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/06/27 06:27 MHDA- 2025/06/27 06:28 PMCR- 2025/06/12 CRDT- 2025/06/27 04:47 PHST- 2025/03/20 00:00 [received] PHST- 2025/05/30 00:00 [accepted] PHST- 2025/06/27 06:28 [medline] PHST- 2025/06/27 06:27 [pubmed] PHST- 2025/06/27 04:47 [entrez] PHST- 2025/06/12 00:00 [pmc-release] AID - 10.3389/fped.2025.1597023 [doi] PST - epublish SO - Front Pediatr. 2025 Jun 12;13:1597023. doi: 10.3389/fped.2025.1597023. eCollection 2025. PMID- 40574565 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250713 IS - 2056-4724 (Print) IS - 2056-4724 (Electronic) IS - 2056-4724 (Linking) VI - 11 IP - 4 DP - 2025 Jun 27 TI - How negative life events affect emotional eating in Chinese adolescents: moderated mediation model. PG - e131 LID - 10.1192/bjo.2025.63 [doi] LID - e131 AB - BACKGROUND: Emotional eating, the tendency to eat in response to negative emotions, is rising among adolescents and linked to obesity and mental health issues. While negative life events contribute to emotional eating, the roles of self-control and social support remain unclear. AIMS: This study examined the relationship between negative life events and emotional eating in adolescents, testing self-control as a mediator and perceived social support as a moderator. METHOD: A sample of 740 Chinese high school students (aged 14-18) completed validated measures of negative life events, self-control, perceived social support, and emotional eating. Data were analyzed using SPSS 25.0 (IBM Corp., Armonk, New York, USA)and PROCESS macro for mediation/moderation effects. RESULTS: Negative life events predicted higher emotional eating (beta = 0.11, p < 0.01), while lower self-control mediated this relationship (beta = -0.15, p < 0.001). Perceived social support moderated the association (beta = -0.09, p < 0.05), weakening it among adolescents with stronger support. CONCLUSIONS: Negative life events increase emotional eating, but self-control and social support play key roles. Interventions targeting these factors may reduce emotional eating and improve adolescent well-being. FAU - Tan, Rong AU - Tan R AD - Department of Psychology, School of Humanities and Management, Hunan University of Chinese Medicine, Changsha, Hunan, China. AD - Mental Health Center, Dongguan Jiarong Foreign Language School, Dongguan, Guangdong, China. FAU - Huang, Tao AU - Huang T AD - Mental Health Center, Jiangmen Preschool Education College, Jiangmen, Guangdong, China. AD - School of Psychology, Fujian Normal University, Fuzhou, China. FAU - Li, Yiru AU - Li Y AD - Mental Health Center, Dongguan Jiarong Foreign Language School, Dongguan, Guangdong, China. FAU - Zhang, Yuhe AU - Zhang Y AD - Mental Health Center, Dongguan Jiarong Foreign Language School, Dongguan, Guangdong, China. FAU - Li, Xijin AU - Li X AD - Mental Health Center, Dongguan Jiarong Foreign Language School, Dongguan, Guangdong, China. FAU - Lin, Xuanxuan AU - Lin X AD - School of Education, Huazhong University of Science and Technology, Wuhan, China. FAU - Liao, Zhenjiang AU - Liao Z AUID- ORCID: 0000-0003-3949-2682 AD - Department of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. FAU - Huang, Qiuping AU - Huang Q AD - Department of Psychology, School of Humanities and Management, Hunan University of Chinese Medicine, Changsha, Hunan, China. LA - eng PT - Journal Article DEP - 20250627 PL - England TA - BJPsych Open JT - BJPsych open JID - 101667931 PMC - PMC12247071 OTO - NOTNLM OT - Negative life events OT - emotional eating OT - perceived social support OT - self-control COIS- None. EDAT- 2025/06/27 06:27 MHDA- 2025/06/27 06:28 PMCR- 2025/06/27 CRDT- 2025/06/27 03:32 PHST- 2025/06/27 06:28 [medline] PHST- 2025/06/27 06:27 [pubmed] PHST- 2025/06/27 03:32 [entrez] PHST- 2025/06/27 00:00 [pmc-release] AID - S2056472425000638 [pii] AID - 10.1192/bjo.2025.63 [doi] PST - epublish SO - BJPsych Open. 2025 Jun 27;11(4):e131. doi: 10.1192/bjo.2025.63. PMID- 40573140 OWN - NLM STAT- MEDLINE DCOM- 20250627 LR - 20250629 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 12 DP - 2025 Jun 18 TI - Feeding Challenges in Trisomy 21: Prevalence and Characteristics of Feeding Disorders and Food Neophobia-A Cross-Sectional Study of Polish Children and Adolescents with Down Syndrome. LID - 10.3390/nu17122030 [doi] LID - 2030 AB - BACKGROUND: Food neophobia, defined as reluctance to try new foods, may lead to nutritional deficiencies and complicate dietary management-especially in individuals with Down syndrome, who often present with oral-motor dysfunction. This condition may result in nutritional deficiencies and difficulties in adhering to dietary recommendations, particularly in individuals with comorbidities. In individuals with Down syndrome (DS), who frequently present with oral motor disorders and chronic diseases, the problem may be especially pronounced. OBJECTIVES: The aim of the study was to assess the risk of food neophobia and feeding difficulties in children, adolescents, and young adults with Down syndrome, as well as their associations with age, gender, and body weight. METHODS: The research was conducted using the CAWI method among 310 caregivers of individuals with DS in Poland. Two validated tools were employed: the Montreal Children's Hospital Feeding Scale (MCH-FS) and the Food Neophobia Scale for Children (FNSC). Body mass index (BMI), comorbidities, and demographic data were also analyzed. RESULTS: Findings revealed that the majority of participants (55.2%) had normal body weight, while 19.4% were undernourished and 6.5% were classified as obese. Feeding difficulties of moderate to very high severity were reported in 26.5% of the participants. A high risk of food neophobia was identified in 41.3% of respondents, most frequently in the preschool age group. A statistically significant association was observed between age and the severity of both feeding difficulties and neophobia (p < 0.05). However, no significant relationships were found with gender or body weight. CONCLUSIONS: Feeding difficulties and food neophobia are prevalent among individuals with Down syndrome, particularly in preschool-aged children. The findings highlight the necessity of an interdisciplinary therapeutic approach and the individualization of dietary interventions, taking developmental age into account. Further studies are warranted, with consideration of environmental and psychosocial factors. FAU - Bialek-Dratwa, Agnieszka AU - Bialek-Dratwa A AUID- ORCID: 0000-0002-7798-6424 AD - Department of Human Nutrition, Department of Dietetics, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, Jordana 19, 41-808 Zabrze, Poland. FAU - Zur, Sebastian AU - Zur S AUID- ORCID: 0000-0002-9970-984X AD - Department of Human Nutrition, Department of Dietetics, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, Jordana 19, 41-808 Zabrze, Poland. FAU - Sokal, Adam AU - Sokal A AD - Department of Human Nutrition, Department of Dietetics, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, Jordana 19, 41-808 Zabrze, Poland. FAU - Staskiewicz-Bartecka, Wiktoria AU - Staskiewicz-Bartecka W AUID- ORCID: 0000-0003-2420-5935 AD - Department of Food Technology and Quality Evaluation, Department of Dietetics, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, Jordana 19, 41-808 Zabrze, Poland. FAU - Kowalski, Oskar AU - Kowalski O AD - Department of Human Nutrition, Department of Dietetics, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, Jordana 19, 41-808 Zabrze, Poland. LA - eng PT - Journal Article DEP - 20250618 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Down Syndrome/psychology/complications/epidemiology MH - Male MH - Female MH - Poland/epidemiology MH - Adolescent MH - Child MH - Cross-Sectional Studies MH - Prevalence MH - *Feeding and Eating Disorders/epidemiology/psychology MH - Child, Preschool MH - Young Adult MH - *Feeding Behavior/psychology MH - Adult MH - Body Mass Index PMC - PMC12196201 OTO - NOTNLM OT - Down's syndrome OT - children OT - feeding disorders OT - food neophobia COIS- The authors declare no conflicts of interest. EDAT- 2025/06/27 06:27 MHDA- 2025/06/27 06:28 PMCR- 2025/06/18 CRDT- 2025/06/27 01:07 PHST- 2025/04/14 00:00 [received] PHST- 2025/06/10 00:00 [revised] PHST- 2025/06/13 00:00 [accepted] PHST- 2025/06/27 06:28 [medline] PHST- 2025/06/27 06:27 [pubmed] PHST- 2025/06/27 01:07 [entrez] PHST- 2025/06/18 00:00 [pmc-release] AID - nu17122030 [pii] AID - nutrients-17-02030 [pii] AID - 10.3390/nu17122030 [doi] PST - epublish SO - Nutrients. 2025 Jun 18;17(12):2030. doi: 10.3390/nu17122030. PMID- 40573104 OWN - NLM STAT- MEDLINE DCOM- 20250627 LR - 20250629 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 12 DP - 2025 Jun 13 TI - Awareness of Eating Disorders, Nutritional Knowledge, and Emotionally Driven Eating Among Polish Adolescents Aged 15-17-A Pilot Study. LID - 10.3390/nu17121994 [doi] LID - 1994 AB - Background/Objectives: Despite the growing awareness of nutrition and the popularity of healthy lifestyles among adolescents, disordered eating behaviors-such as anorexia nervosa, bulimia nervosa, binge eating disorder (BED), and avoidant/restrictive food intake disorder (ARFID)-remain significant public health concerns. ARFID, officially recognized only in 2013, is still poorly understood among youth. This study aimed to assess the relationship between adolescents' nutritional knowledge, emotional regulation, media influence, and eating behaviors. Methods: A cross-sectional study was conducted in 2024 among 120 students aged 15-17 attending W. Reymont Secondary School No. II in Ostrow Wielkopolski, Poland. Participants completed a custom-designed, paper-based questionnaire consisting of 30 single-choice questions and demographic items. The instrument assessed knowledge of eating disorders, body satisfaction, social media impact, and the emotional determinants of food choices. The tool was developed with expert input but has not undergone formal psychometric validation. While many adolescents demonstrated basic nutritional knowledge-such as awareness of BMI norms and food group distribution-they often failed to apply this knowledge to their dietary behaviors. Results: Significant gender differences were observed: girls were more likely to restrict food intake, report emotional eating, and engage in slimming behaviors, while boys were less emotionally reactive and less influenced by social media. Most participants reported eating one meal daily with family but rarely discussed nutrition at home. Emotional involvement in eating, particularly among girls, emerged as a key factor, more influential than social media in shaping dietary behaviors. Conclusions: The findings highlight a clear gap between nutritional knowledge and actual behavior among adolescents, driven in part by emotional dysregulation and body image concerns. School-based interventions should incorporate not only nutritional education but also emotional regulation strategies and media literacy to effectively support healthy eating behaviors in youth. FAU - Zieba, Marlena AU - Zieba M AD - Faculty of Medicine and Health Science, University of Kalisz, Wojciecha Boguslawskiego Square 2, 62-800 Kalisz, Poland. FAU - Jaskula, Marta AU - Jaskula M AUID- ORCID: 0000-0003-4193-614X AD - Faculty of Medicine and Health Science, University of Kalisz, Wojciecha Boguslawskiego Square 2, 62-800 Kalisz, Poland. FAU - Lachowicz-Wisniewska, Sabina AU - Lachowicz-Wisniewska S AUID- ORCID: 0000-0001-6182-0211 AD - Faculty of Medicine and Health Science, University of Kalisz, Wojciecha Boguslawskiego Square 2, 62-800 Kalisz, Poland. LA - eng PT - Journal Article DEP - 20250613 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - Pilot Projects MH - Poland MH - *Feeding and Eating Disorders/psychology MH - *Health Knowledge, Attitudes, Practice MH - Cross-Sectional Studies MH - *Feeding Behavior/psychology MH - Surveys and Questionnaires MH - *Emotions MH - *Adolescent Behavior/psychology PMC - PMC12195971 OTO - NOTNLM OT - adolescent awareness OT - eating disorders OT - prevalence of disorders COIS- The authors declare no conflicts of interest. EDAT- 2025/06/27 06:26 MHDA- 2025/06/27 06:27 PMCR- 2025/06/13 CRDT- 2025/06/27 01:06 PHST- 2025/04/21 00:00 [received] PHST- 2025/05/25 00:00 [revised] PHST- 2025/06/09 00:00 [accepted] PHST- 2025/06/27 06:27 [medline] PHST- 2025/06/27 06:26 [pubmed] PHST- 2025/06/27 01:06 [entrez] PHST- 2025/06/13 00:00 [pmc-release] AID - nu17121994 [pii] AID - nutrients-17-01994 [pii] AID - 10.3390/nu17121994 [doi] PST - epublish SO - Nutrients. 2025 Jun 13;17(12):1994. doi: 10.3390/nu17121994. PMID- 40573076 OWN - NLM STAT- MEDLINE DCOM- 20250627 LR - 20250629 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 12 DP - 2025 Jun 10 TI - Validation of the Texas School Physical Activity and Nutrition (SPAN) Dietary Index Against the Healthy Eating Index Among Elementary-Aged Students. LID - 10.3390/nu17121965 [doi] LID - 1965 AB - Objective: Assess the accuracy of the Texas School Physical Activity and Nutrition (SPAN) survey's diet quality index against the 24 h recall-based Healthy Eating Index (HEI-2020). Methods: Fifty-one rising third and fourth graders (mean age 9.5 yrs., SD = 1.03 yrs.) from a summer program completed the SPAN survey and a 24 h dietary recall on the same day. The study compared SPAN HEI scores from survey food frequency items to HEI-2020 scores from recalls using Nutrition Data System for Research (NDS-R) software, evaluating correlations and agreement metrics. Results: SPAN HEI averaged 36.87 (SD = 3.78), while recall-derived HEI was 49.05 (SD = 11.92). The mean difference between indices was 12.18 (SD = 10.83), with an absolute difference of 13.51 (SD = 9.01). Bland-Altman analysis indicated limits of agreement from -9.05 to 33.40. Spearman correlation between SPAN HEI and recall HEI was r = 0.44 (p < 0.01), with an ICC of 0.45 (95% CI = 0.04, 0.68). Conclusions and Implications: After comparing HEI scores from both tools, SPAN HEI and HEI-2020 demonstrated a moderate correlation, indicating that SPAN HEI may serve as a practical and less burdensome alternative for large-scale dietary assessments. While further validation is needed, these findings suggest its potential utility in monitoring diet quality at the population level. FAU - Hunt, Ethan T AU - Hunt ET AUID- ORCID: 0000-0002-7350-7369 AD - Michael & Susan Dell Center for Healthy Living, University of Texas Health Science Center at Houston (UTHealth) School of Public Health in Austin, Austin, TX 78701, USA. FAU - Marshall, Allison N AU - Marshall AN AUID- ORCID: 0000-0002-4266-1830 AD - School of Health, Gerogetown University, Washington, DC 20007, USA. FAU - Malkani, Raja AU - Malkani R AD - Michael & Susan Dell Center for Healthy Living, University of Texas Health Science Center at Houston (UTHealth) School of Public Health in Austin, Austin, TX 78701, USA. FAU - Ranjit, Nalini AU - Ranjit N AD - Michael & Susan Dell Center for Healthy Living, University of Texas Health Science Center at Houston (UTHealth) School of Public Health in Austin, Austin, TX 78701, USA. FAU - Perez, Adriana AU - Perez A AUID- ORCID: 0000-0002-6859-9916 AD - Michael & Susan Dell Center for Healthy Living, University of Texas Health Science Center at Houston (UTHealth) School of Public Health in Austin, Austin, TX 78701, USA. FAU - Badillo, David J AU - Badillo DJ AD - Michael & Susan Dell Center for Healthy Living, University of Texas Health Science Center at Houston (UTHealth) School of Public Health in Austin, Austin, TX 78701, USA. FAU - Gartner, Danielle J AU - Gartner DJ AUID- ORCID: 0000-0002-8169-0183 AD - Michael & Susan Dell Center for Healthy Living, University of Texas Health Science Center at Houston (UTHealth) School of Public Health in Austin, Austin, TX 78701, USA. FAU - Schelfhout, Ashley AU - Schelfhout A AD - Michael & Susan Dell Center for Healthy Living, University of Texas Health Science Center at Houston (UTHealth) School of Public Health in Austin, Austin, TX 78701, USA. FAU - Narayanan, Vijay R AU - Narayanan VR AD - Michael & Susan Dell Center for Healthy Living, University of Texas Health Science Center at Houston (UTHealth) School of Public Health in Austin, Austin, TX 78701, USA. FAU - Pfledderer, Christopher D AU - Pfledderer CD AD - Michael & Susan Dell Center for Healthy Living, University of Texas Health Science Center at Houston (UTHealth) School of Public Health in Austin, Austin, TX 78701, USA. FAU - Hoelscher, Deanna M AU - Hoelscher DM AD - Michael & Susan Dell Center for Healthy Living, University of Texas Health Science Center at Houston (UTHealth) School of Public Health in Austin, Austin, TX 78701, USA. LA - eng GR - NA/Texas Department of State Health Services/ PT - Journal Article PT - Validation Study DEP - 20250610 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - *Diet, Healthy/statistics & numerical data MH - Texas MH - Female MH - Male MH - *Exercise MH - *Schools MH - *Students/statistics & numerical data MH - Mental Recall MH - Reproducibility of Results MH - *Nutrition Surveys MH - *Nutrition Assessment MH - Diet MH - Diet Surveys PMC - PMC12196021 OTO - NOTNLM OT - Healthy Eating Index (HEI) OT - Texas School Physical Activity and Nutrition (Texas SPAN) OT - diet quality OT - validation COIS- The authors declare no conflicts of interest. EDAT- 2025/06/27 06:26 MHDA- 2025/06/27 06:27 PMCR- 2025/06/10 CRDT- 2025/06/27 01:06 PHST- 2025/03/28 00:00 [received] PHST- 2025/06/04 00:00 [revised] PHST- 2025/06/04 00:00 [accepted] PHST- 2025/06/27 06:27 [medline] PHST- 2025/06/27 06:26 [pubmed] PHST- 2025/06/27 01:06 [entrez] PHST- 2025/06/10 00:00 [pmc-release] AID - nu17121965 [pii] AID - nutrients-17-01965 [pii] AID - 10.3390/nu17121965 [doi] PST - epublish SO - Nutrients. 2025 Jun 10;17(12):1965. doi: 10.3390/nu17121965. PMID- 40570037 OWN - NLM STAT- MEDLINE DCOM- 20250626 LR - 20260923 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 6 DP - 2025 TI - Association between functional dentition and ultra-processed food consumption in Brazilian adults: A cross-sectional study. PG - e0325838 LID - 10.1371/journal.pone.0325838 [doi] LID - e0325838 AB - OBJECTIVE: This study aimed to verify if there is an association between functional dentition and ultra-processed diet in Brazilian adults. METHODS: This cross-sectional study used data from the National Health Survey (PNS) 2019. For the present study, we included only adults aged 18-49 (n = 50,146). The outcome was the ultra-processed food consumption score, calculated based on the sum of positive responses regarding the consumption of 10 subgroups of ultra-processed foods on the previous day. These subgroups represent foods widely consumed in Brazil, and the scoring method has been previously validated for this purpose. The main predictor used was the variable 'functional dentition', categorized into individuals with less than 20 teeth and individuals with 20 or more teeth (functional dentition). Multivariate analysis was performed using the Poisson regression model with robust variance to estimate crude and adjusted prevalence ratios (PR). RESULTS: It was observed that the presence of functional dentition (20 or more teeth) was not associated with a greater consumption of an ultra-processed diet (RP = 0.97 [95% CI: 0.91-1.05]), p = 0.578). CONCLUSION: The lack of a significant association between functional dentition and ultra-processed foods consumption suggests that social determinants might play a more important role in shaping dietary habits. The implementation of public policies that promote equitable access to healthy foods and preventive oral health care could contribute to overall health improvements and inequalities reduction. CI - Copyright: (c) 2025 Luiz do Amaral Junior et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - do Amaral Junior, Orlando Luiz AU - do Amaral Junior OL AUID- ORCID: 0000-0002-6611-3871 AD - Postgraduate Program in Dental Sciences, Federal University of Santa Maria, Santa Maria, Brazil. FAU - Braccini Fagundes, Maria Laura AU - Braccini Fagundes ML AUID- ORCID: 0000-0001-5548-7408 AD - Postgraduate Program in Dental Sciences, Federal University of Santa Maria, Santa Maria, Brazil. FAU - Bidinotto, Augusto Bacelo AU - Bidinotto AB AUID- ORCID: 0000-0003-2758-7342 AD - Department of Preventive and Social Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. FAU - Neves, Matheus AU - Neves M AD - Department of Preventive and Social Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. FAU - Hugo, Fernando Neves AU - Hugo FN AUID- ORCID: 0009-0000-4029-4558 AD - College of Dentistry, Department of Epidemiology and Health Promotion, New York University, New York, New York, United States of America. FAU - do Amaral Giordani, Jessye Melgarejo AU - do Amaral Giordani JM AD - Postgraduate Program in Dental Sciences, Federal University of Santa Maria, Santa Maria, Brazil. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250626 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Adult MH - Brazil/epidemiology MH - Cross-Sectional Studies MH - Female MH - Male MH - Middle Aged MH - Adolescent MH - Young Adult MH - *Dentition MH - *Feeding Behavior MH - *Diet MH - *Fast Foods MH - Oral Health MH - Food, Processed PMC - PMC12201631 COIS- The authors have declared that no competing interests exist. EDAT- 2025/06/26 18:38 MHDA- 2025/06/26 18:39 PMCR- 2025/06/26 CRDT- 2025/06/26 14:03 PHST- 2024/12/18 00:00 [received] PHST- 2025/05/19 00:00 [accepted] PHST- 2025/06/26 18:39 [medline] PHST- 2025/06/26 18:38 [pubmed] PHST- 2025/06/26 14:03 [entrez] PHST- 2025/06/26 00:00 [pmc-release] AID - PONE-D-24-56465 [pii] AID - 10.1371/journal.pone.0325838 [doi] PST - epublish SO - PLoS One. 2025 Jun 26;20(6):e0325838. doi: 10.1371/journal.pone.0325838. eCollection 2025. PMID- 40569921 OWN - NLM STAT- MEDLINE DCOM- 20250626 LR - 20261006 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 6 DP - 2025 TI - Mirror, mirror on the coast: Exploring body image perception and its nexus with self-esteem, mental well-being among student population at an education hub in South-India. PG - e0326171 LID - 10.1371/journal.pone.0326171 [doi] LID - e0326171 AB - INTRODUCTION: Young people's body image dissatisfaction (BID) is a worrying problem that could impact both their physical and mental health. In addition to determining the prevalence and severity of BID among college students in the coastal region of Karnataka, India, this cross-sectional study investigated the relationship between BID and anxiety, depression, and self-esteem. MATERIALS AND METHODS: Data was gathered using a variety of social media channels from a sample of 382 students who were older than 18 years. The following validated measures were used: the Hamilton Anxiety Rating Scale for anxiety, the Stunkard Figure Rating Scale for depression, the Body Shape Questionnaire-16B for body shape concern, the Rosenberg Self-Esteem Scale for self-esteem and the Patient Health Questionnaire-9 for depression. Additionally, self-reported anthropometric data and sociodemographic information were gathered. RESULTS: According to the study, 73.03% of participants had a negative perception of their bodies and strongly preferred to have a smaller ideal body image. BID showed a positive correlation with anxiety and depression and a negative correlation with self-esteem. When compared to pupils with normal BMI, those who were overweight or obese showed considerably higher probabilities of being unhappy with their body image. A curious discrepancy between body image dissatisfaction and body form concern was noted, indicating the necessity for a multifaceted evaluation. CONCLUSION: The results highlight the significance of providing thorough, evidence-based therapies that are customized to the individual requirements of college students to address body image concerns. Using a comprehensive strategy that incorporates psychological, emotional, and physical health can help students succeed and thrive. CI - Copyright: (c) 2025 Kini B et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Kini B, Sanjay AU - Kini B S AUID- ORCID: 0000-0002-3571-2337 AD - Department of Community Medicine, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India. FAU - Huchchannavar, Raghavendra AU - Huchchannavar R AD - Department of Community Medicine, KS Hegde Medical Academy, Nitte (Deemed-to-be University), Deralakatte, Mangalore, Karnataka, India. FAU - Doddamani, Akhila AU - Doddamani A AD - Department of Community Medicine, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India. FAU - A, Manjula AU - A M AD - Department of Community Medicine, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India. FAU - Alok, Yash AU - Alok Y AD - Department of Community Medicine, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India. FAU - Kini B, Sandesh AU - Kini B S AUID- ORCID: 0000-0002-6250-2968 AD - Department of Pediatrics, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India. FAU - Bhat N, Anusha AU - Bhat N A AD - Srinivas Institute of Medical Sciences and Research Centre, Mukka, Surathkal, Mangalore, Karnataka, India. FAU - Krishnan, Athulya AU - Krishnan A AD - Prasanna School of Public Health, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India. LA - eng SI - figshare/(https://doi.org/10.6084/m9.figshare.25559100.v1). PT - Journal Article DEP - 20250626 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Self Concept MH - Female MH - Male MH - *Students/psychology MH - *Body Image/psychology MH - Young Adult MH - India/epidemiology MH - Cross-Sectional Studies MH - Depression/psychology/epidemiology MH - Adolescent MH - Anxiety/psychology/epidemiology MH - *Mental Health MH - Surveys and Questionnaires MH - Adult PMC - PMC12200845 COIS- The authors have declared that no competing interests exist. EDAT- 2025/06/26 18:37 MHDA- 2025/06/26 18:38 PMCR- 2025/06/26 CRDT- 2025/06/26 13:33 PHST- 2024/06/11 00:00 [received] PHST- 2025/05/27 00:00 [accepted] PHST- 2025/06/26 18:38 [medline] PHST- 2025/06/26 18:37 [pubmed] PHST- 2025/06/26 13:33 [entrez] PHST- 2025/06/26 00:00 [pmc-release] AID - PONE-D-24-23548 [pii] AID - 10.1371/journal.pone.0326171 [doi] PST - epublish SO - PLoS One. 2025 Jun 26;20(6):e0326171. doi: 10.1371/journal.pone.0326171. eCollection 2025. PMID- 40568619 OWN - NLM STAT- MEDLINE DCOM- 20250626 LR - 20250627 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 14 DP - 2025 TI - Determining the level of knowledge and consumption of probiotics and prebiotics among athletes in Jordan. PG - e43 LID - 10.1017/jns.2025.10013 [doi] LID - e43 AB - Interest in probiotics and prebiotics in sports nutrition is growing, but research on Jordanian athletes remains limited. While gut microbiota influences athletic performance, little is known about athletes' understanding and use of probiotic- and prebiotic-rich foods in this region. This exploratory study investigates the knowledge, dietary habits, and correlations with gastrointestinal (GI) problems among Jordanian athletes to inform future research and interventions. The study provides insights into how awareness and consumption of gut-supportive foods can impact GI health, offering broader nutritional implications for global dietary strategies for athletes. A standardised questionnaire was administered to 324 athletes (ages 18-22) to assess knowledge, dietary practices, and GI symptoms. Descriptive statistics summarised the data, and chi-square tests examined associations among knowledge, diet, and GI symptoms (p < 0.05). Knowledge and diet were scored based on correct responses and reported intake of gut-supporting foods. Results showed that 55.9% of athletes were familiar with probiotics and 32.1% with prebiotics. The majority reported low consumption of probiotic- and prebiotic-rich foods, with 72.2% scoring low on diet intake. Although 60.5% seldom consumed fast food, overall intake of gut-supportive foods was limited. No statistically significant associations were found, but a weak positive trend between dietary habits and GI symptoms was observed, suggesting diet may have a modest influence on GI health. Living arrangements influenced both dietary choices and GI symptoms. This study highlights the need for targeted nutrition education to improve awareness and intake of probiotics and prebiotics, potentially supporting GI health and enhancing athletic performance. CI - (c) The Author(s) 2025. FAU - Al-Maseimi, Ola D AU - Al-Maseimi OD AUID- ORCID: 0000-0002-3622-8109 AD - Department of Nutrition and Food Science, Faculty of Allied Medical Sciences, Al-Balqa Applied University, Al-Salt, Jordan. FAU - Ahmad, Leena AU - Ahmad L AD - Department of Nutrition, Faculty of Pharmacy & Medical Sciences, University of Petra, Amman, Jordan. FAU - Elsahoryi, Nour A AU - Elsahoryi NA AUID- ORCID: 0000-0003-2029-4045 AD - Department of Nutrition, Faculty of Pharmacy & Medical Sciences, University of Petra, Amman, Jordan. FAU - Al-Maaitah, Lena AU - Al-Maaitah L AUID- ORCID: 0009-0008-2774-3329 AD - Department of Nutrition and Food Science, Mutah University, Al-Karak, Jordan. LA - eng PT - Journal Article DEP - 20250616 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 RN - 0 (Prebiotics) SB - IM MH - Humans MH - *Probiotics/administration & dosage MH - Jordan MH - *Prebiotics/administration & dosage MH - Male MH - Female MH - *Athletes MH - Young Adult MH - *Health Knowledge, Attitudes, Practice MH - Adolescent MH - Surveys and Questionnaires MH - Diet MH - Feeding Behavior MH - Gastrointestinal Diseases/prevention & control MH - Gastrointestinal Microbiome MH - Adult MH - Cross-Sectional Studies PMC - PMC12187486 OTO - NOTNLM OT - CVI, Content Validity Index OT - CVR, Content Validity Ratio OT - Dietary practices OT - GI, Gastrointestinal OT - Jordanian athletes OT - Nutritional knowledge OT - PA, Physical activity OT - Prebiotics OT - Probiotics OT - SCFAs, Short-chain fatty acids OT - SD, Standard deviation OT - SPSS, Statistical Package for Social Science OT - Sports nutrition OT - Supplement usage OT - URTIs, Upper Respiratory Tract Infections COIS- The author(s) declare(s) that there are no competing interests regarding the publication of this paper. EDAT- 2025/06/26 06:27 MHDA- 2025/06/26 06:28 PMCR- 2025/06/16 CRDT- 2025/06/26 05:32 PHST- 2024/07/24 00:00 [received] PHST- 2025/04/30 00:00 [revised] PHST- 2025/05/09 00:00 [accepted] PHST- 2025/06/26 06:28 [medline] PHST- 2025/06/26 06:27 [pubmed] PHST- 2025/06/26 05:32 [entrez] PHST- 2025/06/16 00:00 [pmc-release] AID - S204867902510013X [pii] AID - 10.1017/jns.2025.10013 [doi] PST - epublish SO - J Nutr Sci. 2025 Jun 16;14:e43. doi: 10.1017/jns.2025.10013. eCollection 2025. PMID- 40564826 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250628 IS - 2075-4418 (Print) IS - 2075-4418 (Electronic) IS - 2075-4418 (Linking) VI - 15 IP - 12 DP - 2025 Jun 13 TI - Bioelectrical Impedance Analysis Versus Dual X-Ray Absorptiometry for Obesity Assessment in Pediatric Populations: A Systematic Review. LID - 10.3390/diagnostics15121505 [doi] LID - 1505 AB - Objectives: Pediatric obesity represents a significant public health challenge, requiring accurate and accessible tools for assessing body composition in pediatric populations. This systematic review (PROSPERO CRD42024592366) compares the methodological accuracy and clinical utility of bioelectrical impedance analysis (BIA) and dual x-ray absorptiometry (DXA) in evaluating obesity among children and adolescents. Methods: Utilizing a comprehensive search across PubMed, EMBASE, and Web of Science between 1 January 2014 and 31 December 2024, we identified 28 studies meeting our inclusion criteria. The studies included involved participants aged 2-17 years with obesity and compared BIA with DXA as the reference standard. The exclusion criteria were studies focusing on adults, those that assessed BC solely using anthropometry, and those that did not report primary outcomes relevant to the comparison of BIA vs. DXA. Results: The findings reveal that despite recent technological advances improving BIA's precision, it consistently underestimates body fat percentage and fat mass, particularly in overweight and obese pediatric populations. DXA it is often used as a reference method in the evaluation of whole-body composition due to its higher accuracy and reliability. BIA offers significant practical advantages in accessibility, cost-effectiveness, and portability, but enhancements are needed to improve its accuracy for individual-level assessments. Conclusions: While BIA shows promise as a practical tool for body composition assessment in children, its accuracy varies significantly by device type. Multi-frequency segmental analyzers, such as InBody 720, demonstrate better agreement with DXA, whereas simpler models tend to underestimate fat mass. Therefore, conclusions regarding BIA performance should be device-specific and its clinical utility should be carefully weighed based on the technology used. FAU - Manole, Lorena Mihaela AU - Manole LM AUID- ORCID: 0009-0003-6798-9984 AD - Department of Mother and Child, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. FAU - Ghiga, Gabriela AU - Ghiga G AD - Department of Mother and Child, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. AD - Saint Mary Emergency Children Hospital, 700309 Iasi, Romania. FAU - Iftinchi, Otilia AU - Iftinchi O AD - Department of Mother and Child, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. AD - Saint Mary Emergency Children Hospital, 700309 Iasi, Romania. FAU - Boca, Laura Otilia AU - Boca LO AD - Department of Mother and Child, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. AD - Saint Mary Emergency Children Hospital, 700309 Iasi, Romania. FAU - Donos, Madalina Andreea AU - Donos MA AD - Department of Mother and Child, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. AD - Saint Mary Emergency Children Hospital, 700309 Iasi, Romania. FAU - Tarca, Elena AU - Tarca E AUID- ORCID: 0000-0002-3018-8011 AD - Department of Pediatric Surgery and Orthopedics, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania. FAU - Ionut, Nistor AU - Ionut N AD - Department of Medicine, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. AD - Department of Nephrology, "Dr. C.I. Parhon" Clinical Hospital, 700503 Iasi, Romania. FAU - Revenco, Ninel AU - Revenco N AUID- ORCID: 0000-0002-5229-7841 AD - Department of Pediatrics, University of Medicine and Pharmaceutics "Nicolae Testemitanu", MD-2001 Chisinau, Moldova. FAU - Margasoiu, Iulia AU - Margasoiu I AUID- ORCID: 0009-0004-4944-1445 AD - Department of Mother and Child, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. FAU - Trandafir, Laura Mihaela AU - Trandafir LM AUID- ORCID: 0000-0002-8326-7610 AD - Department of Mother and Child, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. AD - Saint Mary Emergency Children Hospital, 700309 Iasi, Romania. LA - eng PT - Journal Article PT - Review DEP - 20250613 PL - Switzerland TA - Diagnostics (Basel) JT - Diagnostics (Basel, Switzerland) JID - 101658402 PMC - PMC12192207 OTO - NOTNLM OT - bioelectrical impedance OT - body composition OT - childhood obesity OT - dual X-ray absorptiometry OT - pediatric COIS- The authors declare no conflicts of interest. EDAT- 2025/06/26 06:27 MHDA- 2025/06/26 06:28 PMCR- 2025/06/13 CRDT- 2025/06/26 01:10 PHST- 2025/04/07 00:00 [received] PHST- 2025/06/02 00:00 [revised] PHST- 2025/06/11 00:00 [accepted] PHST- 2025/06/26 06:28 [medline] PHST- 2025/06/26 06:27 [pubmed] PHST- 2025/06/26 01:10 [entrez] PHST- 2025/06/13 00:00 [pmc-release] AID - diagnostics15121505 [pii] AID - diagnostics-15-01505 [pii] AID - 10.3390/diagnostics15121505 [doi] PST - epublish SO - Diagnostics (Basel). 2025 Jun 13;15(12):1505. doi: 10.3390/diagnostics15121505. PMID- 40564753 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250628 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 6 DP - 2025 Jun 18 TI - Detecting Disordered Eating Behaviors in Greek Youth with Type 1 Diabetes Mellitus by Using the Diabetes Eating Problem Survey-Revised (DEPS-R): Associations with Insulin Restriction, Glycemic Control, and Anthropometric Parameters. LID - 10.3390/children12060795 [doi] LID - 795 AB - Background/Objectives: This study assesses the prevalence of diabulimia in Greek children and adolescents with Type 1 Diabetes Mellitus (T1DM) by using the Diabetes Eating Problem Survey-Revised (DEPS-R) questionnaire and addresses a gap in the literature on eating disorders (EDs) and disordered eating behaviors (DEBs) in this population. The DEPS-R threshold score of >/=20, although originally established in international studies, has also been applied in Greek adult validation studies. However, it has not yet been formally validated in Greek youth. Methods: Participants aged 9-18 years, diagnosed with T1DM a minimum of one year before the start of the study, were recruited from three pediatric departments in Thessaloniki and were asked to complete the Greek version of the DEPS-R questionnaire. Appropriate statistical analysis was employed to investigate the association of the DEPS-R score with anthropometric, demographic, and glycemic variables derived from the clinical assessment and the patient's medical records. Results: Girls had significantly higher DEPS-R scores compared with boys. Significant positive associations were observed between the DEPS-R score and both age (r = 0.212, p = 0.020) and Body Mass Index (BMI) (r = 0.419, p < 0.001). A significant association with Glycated Hemoglobin (HbA1c) (r = 0.182, p = 0.047) suggested that poorer glycemic control may be linked to disordered eating, although no significant associations were identified with physical activity or type of insulin therapy. Conclusions: Older age, higher Body Mass Index (BMI) and elevated Glycated Hemoglobin (HbA1c) levels are associated with increased risk of disordered eating in youth with T1DM, especially in girls. Therefore, the implementation of early screening and targeted interventions is imperative. FAU - Oikonomou, Anastasia AU - Oikonomou A AUID- ORCID: 0009-0002-4450-6612 AD - Program of Postgraduate Studies "Adolescent Medicine and Adolescent Health Care", School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. FAU - Christoforidis, Athanasios AU - Christoforidis A AUID- ORCID: 0000-0003-4964-5726 AD - Program of Postgraduate Studies "Adolescent Medicine and Adolescent Health Care", School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. AD - 1st Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Ippokratio General Hospital, 54642 Thessaloniki, Greece . FAU - Kotanidou, Eleni P AU - Kotanidou EP AUID- ORCID: 0000-0002-8292-4471 AD - Program of Postgraduate Studies "Adolescent Medicine and Adolescent Health Care", School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. AD - 2nd Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, University General Hospital AHEPA, 54636 Thessaloniki, Greece. FAU - Giannopoulou, Ioanna AU - Giannopoulou I AD - 2nd Department of Psychiatry, Faculty of Medicine, School of Health Sciences, National and Kapodistrian University of Athens, Attikon University General Hospital, 12462 Athens, Greece. FAU - Paschalidou, Eleni AU - Paschalidou E AUID- ORCID: 0000-0002-3453-3986 AD - 3rd Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Ippokratio General Hospital, 54642 Thessaloniki, Greece. FAU - Tsinopoulou, Vasiliki Rengina AU - Tsinopoulou VR AUID- ORCID: 0000-0002-2531-2313 AD - Program of Postgraduate Studies "Adolescent Medicine and Adolescent Health Care", School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. AD - 2nd Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, University General Hospital AHEPA, 54636 Thessaloniki, Greece. FAU - Sotiriou, Georgia AU - Sotiriou G AUID- ORCID: 0009-0002-4554-3116 AD - Program of Postgraduate Studies "Adolescent Medicine and Adolescent Health Care", School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. AD - 1st Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Ippokratio General Hospital, 54642 Thessaloniki, Greece . FAU - Tsiroukidou, Kyriaki AU - Tsiroukidou K AUID- ORCID: 0009-0000-7449-5083 AD - 3rd Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Ippokratio General Hospital, 54642 Thessaloniki, Greece. FAU - Galli-Tsinopoulou, Assimina AU - Galli-Tsinopoulou A AUID- ORCID: 0000-0002-8503-3893 AD - Program of Postgraduate Studies "Adolescent Medicine and Adolescent Health Care", School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. AD - 2nd Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, University General Hospital AHEPA, 54636 Thessaloniki, Greece. LA - eng PT - Journal Article DEP - 20250618 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12191822 OTO - NOTNLM OT - DEPS-R OT - adolescents OT - diabulimia OT - disordered eating behaviors OT - eating disorders OT - type 1 diabetes Mellitus COIS- The authors declare no conflicts of interest. EDAT- 2025/06/26 06:27 MHDA- 2025/06/26 06:28 PMCR- 2025/06/18 CRDT- 2025/06/26 01:09 PHST- 2025/05/06 00:00 [received] PHST- 2025/06/02 00:00 [revised] PHST- 2025/06/17 00:00 [accepted] PHST- 2025/06/26 06:28 [medline] PHST- 2025/06/26 06:27 [pubmed] PHST- 2025/06/26 01:09 [entrez] PHST- 2025/06/18 00:00 [pmc-release] AID - children12060795 [pii] AID - children-12-00795 [pii] AID - 10.3390/children12060795 [doi] PST - epublish SO - Children (Basel). 2025 Jun 18;12(6):795. doi: 10.3390/children12060795. PMID- 40564749 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250628 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 6 DP - 2025 Jun 17 TI - Impact of Absence Seizures on Physical Activity Levels in Children: A Cross-Sectional Study. LID - 10.3390/children12060791 [doi] LID - 791 AB - BACKGROUND: Physical activity is essential for the physical and psychological development of children, contributing to both fitness and overall well-being. However, children with neurological conditions such as childhood absence seizures (CAE), a type of epilepsy characterized by brief episodes of impaired consciousness, may face barriers to participating in regular physical activities. This limitation can negatively affect their quality of life, motor coordination, and cognitive function. Despite this, there is limited research focusing on the physical activity levels of children with absence seizures in comparison to healthy children. METHODS: This study aims to compare physical activity levels in children with absence seizures and healthy controls, using the Physical Activity Questionnaire for Children (PAQ-C), a validated tool for assessing children's engagement in physical activity. The sample included 125 children with absence seizures and 125 healthy controls. The study also assessed anxious-depressive traits using the Children's Depression Inventory (CDI-2) and the Multidimensional Anxiety Scale for Children (MASC-2). Additionally, seizure frequency and severity were documented for the seizure group, and the impact of different treatment regimens (levetiracetam, valproate, lamotrigine) was explored. RESULTS: The results revealed that children with absence seizures exhibited lower physical activity levels compared to healthy children, although the difference did not reach statistical significance. Furthermore, they had higher scores for anxious-depressive traits. There were no significant differences in physical activity levels between the different treatment groups. The study also found that lower physical activity was correlated with poorer quality of life and increased psychological distress in the seizure group. CONCLUSION: Children with absence seizures face significant barriers to physical activity, which may be further compounded by psychological distress. These findings emphasize the need for targeted interventions to improve physical activity and address mental health concerns in this population. By enhancing physical activity levels and supporting psychological well-being, interventions can improve the quality of life and overall health of children with absence seizures. Additionally, the results highlight the importance of promoting inclusive physical activity programs for children with neurological conditions. FAU - Gnazzo, Martina AU - Gnazzo M AD - Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy. FAU - Baldini, Valentina AU - Baldini V AUID- ORCID: 0000-0001-5795-5834 AD - Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy. AD - Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy. FAU - Carotenuto, Marco AU - Carotenuto M AUID- ORCID: 0000-0002-8136-7597 AD - Clinic of Child and Adolescent Neuropsychiatry, Department of Mental Health, Physical and Preventive Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy. FAU - Pisano, Giulia AU - Pisano G AUID- ORCID: 0009-0005-2730-2791 AD - Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy. FAU - Messina, Giovanni AU - Messina G AD - Unit of Dietetics and Sports Medicine, Section of Human Physiology, Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy. FAU - Moscatelli, Fiorenzo AU - Moscatelli F AUID- ORCID: 0000-0003-1274-0332 AD - Department of Education and Sport Sciences, Pegaso Telematic University, 80143 Naples, Italy. FAU - Ruberto, Maria AU - Ruberto M AUID- ORCID: 0009-0003-9583-9203 AD - Department of Education and Sport Sciences, Pegaso Telematic University, 80143 Naples, Italy. LA - eng PT - Journal Article DEP - 20250617 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12191905 OTO - NOTNLM OT - absence seizures OT - anxiety and depression OT - children OT - physical activity OT - quality of life COIS- The authors declare no conflict of interest. EDAT- 2025/06/26 06:27 MHDA- 2025/06/26 06:28 PMCR- 2025/06/17 CRDT- 2025/06/26 01:09 PHST- 2025/03/14 00:00 [received] PHST- 2025/06/10 00:00 [revised] PHST- 2025/06/14 00:00 [accepted] PHST- 2025/06/26 06:28 [medline] PHST- 2025/06/26 06:27 [pubmed] PHST- 2025/06/26 01:09 [entrez] PHST- 2025/06/17 00:00 [pmc-release] AID - children12060791 [pii] AID - children-12-00791 [pii] AID - 10.3390/children12060791 [doi] PST - epublish SO - Children (Basel). 2025 Jun 17;12(6):791. doi: 10.3390/children12060791. PMID- 40564708 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250628 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 6 DP - 2025 Jun 9 TI - Construct Validity and Internal Consistency of the Italian Version of the PedsQL(TM) 4.0 Generic Core Scale and PedsQL(TM) 3.0 Cerebral Palsy Module. LID - 10.3390/children12060749 [doi] LID - 749 AB - BACKGROUND: Health-related quality of life (HRQoL) has emerged as a meaningful outcome measure in clinical trials and healthcare interventions in children with cerebral palsy (CwCP). We assessed the construct validity and internal consistency of the Italian version of the Paediatric QoL inventory (PedsQL(TM)) 4.0 Generic Core Scales (GCS) and PedsQL(TM) 3.0 Cerebral Palsy Module (CPM). METHODS: A total of 125 CwCP and their parents were enrolled. Participants completed both the GCS and the CPM modules, and the results were compared to those of a sample of 121 healthy peers and their parents. The dimensionality of the two modules was assessed through exploratory factor analysis. Construct validity was assessed by a known-groups method evaluating the differences between CwCP and healthy sample. RESULTS: Only a few GCS subscales were unidimensional, while all CPM subscales proved to be unidimensional, except for the Speech and Communication subscales of child self-reports. GCS internal consistency was good for all subscales of the parent proxy-reports, as well as for the Physical Activities and Psychosocial Health subscales of child self-reports. CPM internal consistency was good for both parent proxy-reports and-with a few exceptions-child self-reports. As for the PedsQL(TM) validity, the GCS proved effective in discriminating between CwCP and healthy participants; the CPM showed a significant association between lower neurofunctional abilities and lower HRQoL. Parent-child concordance shows that child self-report scores were always higher than the those of the proxy-reports for both the GCS and CPM modules. CONCLUSIONS: The present study confirms the internal consistency and construct validity of the Italian version of both PedsQL(TM) modules. In CwCP, greater functional disability resulted in lower HRQoL scores, and there was significant discrepancy between the parent and child ratings. FAU - Pedrinelli, Ilaria AU - Pedrinelli I AUID- ORCID: 0000-0001-5217-2726 AD - Pediatric Neuroscience Department, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy. FAU - Biagi, Sofia AU - Biagi S AUID- ORCID: 0009-0006-4361-942X AD - Pediatric Neuroscience Department, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy. FAU - Romeo, Domenico Marco AU - Romeo DM AUID- ORCID: 0000-0002-6229-1208 AD - Paediatric Neurology Unit, Catholic University, 00168 Rome, Italy. FAU - Musto, Elisa AU - Musto E AD - Paediatric Neurology Unit, Catholic University, 00168 Rome, Italy. FAU - Fagiani, Valeria AU - Fagiani V AD - Emergency Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, 20122 Milan, Italy. FAU - Lanza, Martina AU - Lanza M AUID- ORCID: 0009-0000-5970-2523 AD - Neurology, Public Health and Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy. FAU - Guastafierro, Erika AU - Guastafierro E AUID- ORCID: 0000-0002-5051-0207 AD - Neurology, Public Health and Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy. FAU - Colombo, Alice AU - Colombo A AUID- ORCID: 0009-0001-3669-6789 AD - Neurology, Public Health and Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy. FAU - Giordano, Andrea AU - Giordano A AUID- ORCID: 0000-0003-4466-9788 AD - Neurology, Public Health and Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy. FAU - Montomoli, Cristina AU - Montomoli C AUID- ORCID: 0000-0002-8526-5846 AD - Department of Public Health Neuroscience, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Rezzani, Cristiana AU - Rezzani C AD - Department of Public Health Neuroscience, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Casalino, Tiziana AU - Casalino T AD - Pediatric Neuroscience Department, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy. FAU - Mercuri, Eugenio AU - Mercuri E AD - Paediatric Neurology Unit, Catholic University, 00168 Rome, Italy. FAU - Riva, Daria AU - Riva D AUID- ORCID: 0000-0002-9113-894X AD - Pediatric Neuroscience Department, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy. FAU - Leonardi, Matilde AU - Leonardi M AUID- ORCID: 0000-0003-0552-8923 AD - Neurology, Public Health and Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy. FAU - Baranello, Giovanni AU - Baranello G AUID- ORCID: 0000-0003-4871-6692 AD - Paediatric Neurology/Neuromuscular Disorders, University College London, Great Ormond Street Institute of Child Health, Great Ormond Street Hospital NHS Foundation Trust, London WC1N 1EH, UK. FAU - Pagliano, Emanuela AU - Pagliano E AUID- ORCID: 0000-0002-5933-5636 AD - Pediatric Neuroscience Department, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy. LA - eng PT - Journal Article DEP - 20250609 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12191115 OTO - NOTNLM OT - Cerebral Palsy OT - Italian population OT - PedsQL OT - children OT - health-related quality of life COIS- The authors declare no conflicts of interest. The sponsors had no role in the design, execution, interpretation, or writing of the study. EDAT- 2025/06/26 06:27 MHDA- 2025/06/26 06:28 PMCR- 2025/06/09 CRDT- 2025/06/26 01:09 PHST- 2025/05/09 00:00 [received] PHST- 2025/05/31 00:00 [revised] PHST- 2025/06/06 00:00 [accepted] PHST- 2025/06/26 06:28 [medline] PHST- 2025/06/26 06:27 [pubmed] PHST- 2025/06/26 01:09 [entrez] PHST- 2025/06/09 00:00 [pmc-release] AID - children12060749 [pii] AID - children-12-00749 [pii] AID - 10.3390/children12060749 [doi] PST - epublish SO - Children (Basel). 2025 Jun 9;12(6):749. doi: 10.3390/children12060749. PMID- 40564644 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250628 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 6 DP - 2025 May 26 TI - Assessment of Stunting and Its Effect on Wasting in Children Under Two in Rural Madagascar. LID - 10.3390/children12060686 [doi] LID - 686 AB - BACKGROUND/OBJECTIVES: This study aims to determine the prevalence of stunting in children under two years old and its association with the maternal profile (including anthropometric measurements), care, feeding practices, and socioeconomic level. It also attempts to assess if stunting may contribute to an underestimation of wasting by performing a preliminary speculative analysis using the expected height for age instead of the real observed height of the children. METHODS: The study employed a cross-sectional design, examining mother-child pairs in the rural municipality of Ampefy in the Itasy Region of Madagascar, between 2022 and 2023. A total of 437 mother-child (0-24 months) pairs participated in the study. A questionnaire was administered to collect data on the maternal lifestyle. Maternal medical histories were reviewed, and anthropometric parameters of both the mothers and their child were taken by specialized and trained health professionals with multiple years of experience. RESULTS: The prevalence of stunting in children was 57.4% (95% CI: 52.64-62.10). Stunting was associated with maternal anthropometric measurements (p < 0.001), maternal education (p = 0.004), and breastfeeding (p = 0.047), which appears to have a protective effect. The weight-for-length z-score indicated that only 12.4% of the total children were affected by wasting. In the preliminary speculative analysis using the WHO height-for-age standard, the theoretical prevalence of wasting was estimated to be 42.3%, with a considerable prevalence of severe wasting. The main limitations of this study were the possible selection bias, the limitations inherent to the taking of anthropometric measurements in small children, and therefore, the possible misclassification of the children. The use of a theoretical weight-for-length z-score to estimate a theoretical prevalence of wasting using an untested speculative analysis is also a limitation to the validity of the estimation. CONCLUSIONS: Stunting affected over half of the children included in the study (57.4%), but the prevalence of wasting was below what was expected, at 12.4%. In the preliminary speculative analysis using the expected height for age, it was estimated that wasting could possibly affect up to 42.3% of the children. This discrepancy, while it cannot be taken as factual due to the nature of the analysis, could serve as a warning that perhaps the elevated rates of stunting may be masking wasting in some children and other forms of nutritional assessments may be needed in areas where stunting is prevalent. FAU - Rotella, Rosita AU - Rotella R AD - Research Group in Social and Nutritional Epidemiology, Pharmacoepidemiology and Public Health, Department of Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine, Faculty of Pharmacy, Universitat de Valencia, Av. Vicent Andres Estelles s/n, 46100 Burjassot, Spain. AD - Centro Medico-Chirurgico Saint Paul (Change ONG), Andasibe-Ampefy 118, District of Soavinandriana, Itasy Province, Madagascar. FAU - Morales-Suarez-Varela, Maria AU - Morales-Suarez-Varela M AUID- ORCID: 0000-0003-0785-1492 AD - Research Group in Social and Nutritional Epidemiology, Pharmacoepidemiology and Public Health, Department of Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine, Faculty of Pharmacy, Universitat de Valencia, Av. Vicent Andres Estelles s/n, 46100 Burjassot, Spain. AD - Biomedical Research Center in Epidemiology and Public Health Network (CIBERESP), Carlos III Health Institute, Av. Monforte de Lemos 3-5 Pabellon 11 Planta 0, 28029 Madrid, Spain. FAU - Llopis-Gonzalez, Agustin AU - Llopis-Gonzalez A AUID- ORCID: 0000-0001-8701-6918 AD - Research Group in Social and Nutritional Epidemiology, Pharmacoepidemiology and Public Health, Department of Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine, Faculty of Pharmacy, Universitat de Valencia, Av. Vicent Andres Estelles s/n, 46100 Burjassot, Spain. AD - Biomedical Research Center in Epidemiology and Public Health Network (CIBERESP), Carlos III Health Institute, Av. Monforte de Lemos 3-5 Pabellon 11 Planta 0, 28029 Madrid, Spain. FAU - Soriano, Jose M AU - Soriano JM AUID- ORCID: 0000-0003-2846-1311 AD - Observatory of Nutrition and Food Safety for Developing Countries, Food & Health Lab, Institute of Materials Science, University of Valencia, Carrer Catedratico Agustin Escardino 9, 46980 Paterna, Spain. AD - Joint Research Unit on Endocrinology, Nutrition and Clinical Dietetics, University of Valencia-Health Research Institute La Fe, Avda. Fernando Abril Martorell, 106, 46026 Valencia, Spain. LA - eng GR - 2022/0197/Universitat de Valencia/ PT - Journal Article DEP - 20250526 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12191333 OTO - NOTNLM OT - Madagascar OT - infant malnutrition OT - nutritional programs OT - stunting OT - wasting COIS- The authors declare no conflicts of interest. EDAT- 2025/06/26 06:27 MHDA- 2025/06/26 06:28 PMCR- 2025/05/26 CRDT- 2025/06/26 01:08 PHST- 2025/03/12 00:00 [received] PHST- 2025/05/20 00:00 [revised] PHST- 2025/05/22 00:00 [accepted] PHST- 2025/06/26 06:28 [medline] PHST- 2025/06/26 06:27 [pubmed] PHST- 2025/06/26 01:08 [entrez] PHST- 2025/05/26 00:00 [pmc-release] AID - children12060686 [pii] AID - children-12-00686 [pii] AID - 10.3390/children12060686 [doi] PST - epublish SO - Children (Basel). 2025 May 26;12(6):686. doi: 10.3390/children12060686. PMID- 40564631 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250628 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 6 DP - 2025 May 23 TI - Reliability of the Korean Version of the Eating and Drinking Ability Classification System in Children with Cerebral Palsy. LID - 10.3390/children12060673 [doi] LID - 673 AB - BACKGROUND/OBJECTIVES: This study aimed to assess the reliability and validity of the Korean version of the Eating and Drinking Ability Classification System (EDACS) for children with cerebral palsy (CP). METHODS: This was a prospective cross-sectional study conducted to psychometrically assess 40 children with CP. Reliability was evaluated by a physician in pediatric rehabilitation, a speech-language therapist (SaLT), and caregivers. RESULTS: In the evaluation of each level and level of assistance in the EDACS, the agreement observed between the physician and speech therapist was almost perfect (kappaW = 0.940, 0.919). The agreement between the physician and the caregiver was substantial (kappaW = 0.618, 0.592), whereas it was moderate between the therapist and caregiver (kappaW = 0.557, 0.556). Intra-rater reliability remained almost perfect, with the physician (kappaW = 0.979), the SaLT (kappaW = 0.980), and caregivers (kappaW = 0.980). The EDACS showed moderate to high correlation with the Functional Oral Intake Scale, Gross Motor Function Classification System, Manual Ability Classification System, and Communication Function Classification System (Ktau = -0.863, 0.656, 0.720, 0.616). CONCLUSIONS: These findings support the Korean EDACS as a reliable tool for classifying eating and drinking abilities in children with CP, thereby enhancing its clinical utility and communication among non-professionals and professionals. FAU - Hwang, Sangwon AU - Hwang S AUID- ORCID: 0000-0003-3651-2895 AD - Department of Physical Medicine and Rehabilitation, Eulji University Hospital, Daejeon, 95 Dunsanseo-ro, Seo-gu, Daejeon 35233, Republic of Korea. FAU - Jung, Kang-Jae AU - Jung KJ AD - Department of Physical Medicine and Rehabilitation, Eulji University Hospital, Daejeon, 95 Dunsanseo-ro, Seo-gu, Daejeon 35233, Republic of Korea. FAU - Choi, Yeonhee AU - Choi Y AD - Department of Speech and Language Therapy, Eulji University Hospital, Daejeon, 95 Dunsanseo-ro, Seo-gu, Daejeon 35233, Republic of Korea. FAU - Rha, Dong-Wook AU - Rha DW AUID- ORCID: 0000-0002-7153-4937 AD - Department of Rehabilitation Medicine, Severance Hospital, Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea. LA - eng GR - EJBS-22-03/Eulji University/ PT - Journal Article DEP - 20250523 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12190561 OTO - NOTNLM OT - cerebral palsy OT - drinking behavior OT - eating behavior OT - efficiency OT - pediatrics OT - reproducibility of results COIS- The authors declare no conflicts of interest. EDAT- 2025/06/26 06:27 MHDA- 2025/06/26 06:28 PMCR- 2025/05/23 CRDT- 2025/06/26 01:08 PHST- 2025/04/20 00:00 [received] PHST- 2025/05/17 00:00 [revised] PHST- 2025/05/21 00:00 [accepted] PHST- 2025/06/26 06:28 [medline] PHST- 2025/06/26 06:27 [pubmed] PHST- 2025/06/26 01:08 [entrez] PHST- 2025/05/23 00:00 [pmc-release] AID - children12060673 [pii] AID - children-12-00673 [pii] AID - 10.3390/children12060673 [doi] PST - epublish SO - Children (Basel). 2025 May 23;12(6):673. doi: 10.3390/children12060673. PMID- 40562693 OWN - NLM STAT- MEDLINE DCOM- 20250625 LR - 20250628 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 9 IP - 1 DP - 2025 Jun 25 TI - Analysis of parental beliefs and practices leading to excessive screen time in early childhood. LID - 10.1136/bmjpo-2025-003488 [doi] LID - e003488 AB - BACKGROUND: Excessive screen time in young children is a growing concern in the digital age. It is important to explore parental beliefs and practices that could shape children's screen time routines. METHODS: This cross-sectional study surveyed 3624 parents of children aged 2-5 years from five northern Indian states between July and October 2024. The participants completed a validated questionnaire assessing sociodemographic factors, children's screen time duration, parental beliefs and practices related to screen time regulation (guidelines and enforcement), screen use purposes (eg, feeding, chores) and perceived impacts on child development (eg, social skills, attention, speech/language). Data analysis included chi(2) tests and multinomial logistic regression to identify associations between variables. RESULTS: Over 60% of the children spent 2-4 hours daily on screens, with no significant associations between weekday-weekend screen time patterns and sociodemographic factors. Multinomial logistic regression revealed that the odds of excessive screen use were greater among children whose parents were unsure of whether restrictions should be set (AOR=3.03 for 4-6 hours), those whose parents did not set screen time limits (AOR=1.64 for 4-6 hours and AOR=2.07 for >8 hours), those whose parents used screens during feeding (AOR=1.82 for 2-4 hours; AOR=2.66 for 4-6 hours, AOR=2.79 for 4-8 hours and 3.54 for >8 hours) and those whose parents did not believe that screen time hindered speech and language development (AOR=1.77 for 2-4 hours and AOR=2.11 for 4-6 hours). CONCLUSION: Parental factors, including the absence of screen time limits and the cultural use of screens during mealtimes, contribute to excessive screen time. Interventions in India should focus on practical programmes that support parents in managing screen time, tailored to regional and cultural contexts. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Bhutani, Priyank AU - Bhutani P AD - Center for Multidisciplinary Research, Tezpur University, Napaam, Assam, India. FAU - Varghese, Litna A AU - Varghese LA AUID- ORCID: 0009-0004-9585-1656 AD - Department of Audiology and Speech Language Pathology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India. FAU - Bajaj, Gagan AU - Bajaj G AUID- ORCID: 0000-0001-7551-7889 AD - Department of Audiology and Speech Language Pathology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India gagan.bajaj@manipal.edu. FAU - Bhutani, Charul AU - Bhutani C AD - Bhutani Speech and Hearing clinic, New Delhi, India. FAU - Khan, Firoz AU - Khan F AD - National Institute for Research in Digital Health and Data Sciences, ICMR, New Delhi, India. FAU - Menon, Geetha R AU - Menon GR AD - Department of Health Research, Ministry of Health and Family Welfare (MoHFW), New Delhi, India. FAU - Deka, Ramesh Chandra AU - Deka RC AD - Department of Chemical Sciences, Tezpur University, Napaam, Assam, India. FAU - Ray, Suvendra Kumar AU - Ray SK AD - Department of Molecular Biology and Biotechnology, Tezpur University, Napaam, Assam, India. FAU - Satapathy, Siddhartha Sankar AU - Satapathy SS AD - Department of Computer Science and Engineering, Tezpur University, Napaam, Assam, India. LA - eng PT - Journal Article DEP - 20250625 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - *Screen Time MH - Child, Preschool MH - Male MH - Female MH - Cross-Sectional Studies MH - *Parents/psychology MH - India MH - Surveys and Questionnaires MH - Adult MH - Child Development MH - Health Knowledge, Attitudes, Practice MH - *Parenting/psychology PMC - PMC12198805 OTO - NOTNLM OT - Child OT - Growth & Development OT - India OT - Parents OT - Screen time COIS- Competing interests: None declared. EDAT- 2025/06/26 00:27 MHDA- 2025/06/26 00:28 PMCR- 2025/06/25 CRDT- 2025/06/25 21:54 PHST- 2025/03/12 00:00 [received] PHST- 2025/06/16 00:00 [accepted] PHST- 2025/06/26 00:28 [medline] PHST- 2025/06/26 00:27 [pubmed] PHST- 2025/06/25 21:54 [entrez] PHST- 2025/06/25 00:00 [pmc-release] AID - 10.1136/bmjpo-2025-003488 [pii] AID - bmjpo-2025-003488 [pii] AID - 10.1136/bmjpo-2025-003488 [doi] PST - epublish SO - BMJ Paediatr Open. 2025 Jun 25;9(1):e003488. doi: 10.1136/bmjpo-2025-003488. PMID- 40562539 OWN - NLM STAT- MEDLINE DCOM- 20250625 LR - 20250706 IS - 2059-7908 (Print) IS - 2059-7908 (Electronic) IS - 2059-7908 (Linking) VI - 10 IP - 6 DP - 2025 Jun 25 TI - A multi-country comparison between mobile phone surveys and face-to-face household surveys to estimate the prevalence of non-communicable diseases behavioural risk factors in low- and middle-income settings. LID - 10.1136/bmjgh-2024-017785 [doi] LID - e017785 AB - BACKGROUND: Although mobile phone surveys (MPS) are routinely used to collect health information in high-income countries, concerns remain about the impact of bias on population-level estimates in low-income settings and validation studies are lacking. This study aims to compare non-communicable diseases (NCDs) risk factor estimates obtained from MPS and nationally representative face-to-face household surveys in six low- and middle-income settings. METHODS: The MPS contained core questions from the standard STEPwise approach to NCD risk factor surveillance questionnaire. MPS sampling frames were generated by random digit dialling, while data collection was done by interactive voice response and SMS. At the same time, a nationally representative household survey (WHO STEPS) was conducted using multi-stage sampling. Participants aged 18 and older were included. Absolute differences and prevalence ratios, with 95% CIs, were analysed. The distribution of the differences between estimates by sex, age and education was also explored. RESULTS: MPS and STEPS surveys were conducted in Ecuador, Malawi, Morocco, Zambia, Mumbai (India) and Sri Lanka between 2017 and 2022. Overall, MPS estimates of NCDs were most similar to STEPS estimates in Ecuador and Sri Lanka, and most dissimilar in Mumbai and Malawi. Broadly, smoking tobacco, fruit and vegetable consumption, and current drinking questions performed similarly across settings, whereas questions on smokeless tobacco, salt intake and hypertension yielded dissimilar results. CONCLUSIONS: MPS estimates were most similar to household estimates in settings with high levels of mobile phone ownership. MPS have the potential to serve as a valuable tool to monitor and address NCD risk factors, in addition to traditional face-to-face household surveys. However, producing nationally representative MPS estimates requires careful adjustments to sampling strategies, addressing coverage biases and overcoming technological limitations. Currently, face-to-face household surveys reach a more representative sample of the population, including those in remote and lower educational demographics. CI - (c) World Health Organization 2025. Licensee BMJ. FAU - Fernandez-Nino, Julian A AU - Fernandez-Nino JA AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Ahmed, Saifuddin AU - Ahmed S AD - Population, Family And Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Al Kibria, Gulam Muhammed AU - Al Kibria GM AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Davlin, Stacy AU - Davlin S AD - CDC Foundation Inc, Atlanta, Georgia, USA. FAU - Phadnis, Rachael AU - Phadnis R AUID- ORCID: 0000-0002-0150-7749 AD - CDC Foundation Inc, Atlanta, Georgia, USA. FAU - Cowan, Melanie AU - Cowan M AD - World Health Organization, Geneva, Switzerland. FAU - Costa Beltran, Romina AU - Costa Beltran R AD - Ministry of Public Health of Ecuador, Quito, Ecuador. FAU - Lopez, Juan Carlos Zevallos AU - Lopez JCZ AD - Ministry of Public Health of Ecuador, Quito, Ecuador. FAU - Vasconez, Juan AU - Vasconez J AD - Ministry of Public Health of Ecuador, Quito, Ecuador. FAU - Masiye, Jones K AU - Masiye JK AD - Government of Malawi Ministry of Health, Lilongwe, Malawi. FAU - El Berri, Hicham AU - El Berri H AD - Government of the Kingdom of Morocco Ministry of Public Health, Rabat, Morocco. FAU - Mounach, Samir AU - Mounach S AD - Government of the Kingdom of Morocco Ministry of Public Health, Rabat, Morocco. FAU - Gomare, Mangla AU - Gomare M AD - Brihanmumbai Municipal Corporation, Mumbai, Maharashtra, India. FAU - Shah, Daksha AU - Shah D AD - Brihanmumbai Municipal Corporation, Mumbai, Maharashtra, India. FAU - Khan, Gulnar AU - Khan G AD - Brihanmumbai Municipal Corporation, Mumbai, Maharashtra, India. FAU - Dave, Niraj AU - Dave N AD - Nielsen India, Mumbai, Maharashtra, India. FAU - Wickramasinghe, Champika AU - Wickramasinghe C AD - Government of Sri Lanka Ministry of Health Sri Lanka, Colombo, Sri Lanka. FAU - Perera, Udara AU - Perera U AD - Government of Sri Lanka Ministry of Health Sri Lanka, Colombo, Sri Lanka. FAU - Lishimpi, Kennedy AU - Lishimpi K AD - Zambia Ministry of Health, Lusaka, Zambia. FAU - Mutale, Wilbroad AU - Mutale W AD - Zambia Ministry of Health, Lusaka, Zambia. FAU - Siyumbwa, Namasiku AU - Siyumbwa N AUID- ORCID: 0009-0007-1387-8882 AD - Zambia Ministry of Health, Lusaka, Zambia. FAU - Riley, Leanne AU - Riley L AD - World Health Organization, Geneva, Switzerland. FAU - Gibson, Dustin G AU - Gibson DG AUID- ORCID: 0000-0002-9073-3376 AD - Center for Global Digital Health Innovation, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA dgibso28@jhu.edu. LA - eng GR - 001/WHO_/World Health Organization/International PT - Comparative Study PT - Journal Article DEP - 20250625 PL - England TA - BMJ Glob Health JT - BMJ global health JID - 101685275 SB - IM MH - Humans MH - *Noncommunicable Diseases/epidemiology MH - Male MH - Adult MH - Female MH - Middle Aged MH - *Cell Phone/statistics & numerical data MH - Prevalence MH - Risk Factors MH - Young Adult MH - Adolescent MH - *Developing Countries/statistics & numerical data MH - Surveys and Questionnaires MH - Aged MH - *Health Surveys/methods PMC - PMC12198783 OTO - NOTNLM OT - Cross-sectional survey OT - Epidemiology OT - Global Health COIS- Competing interests: Where authors are identified as personnel of the WHO, the authors alone are responsible for the views expressed in this publication and they do not necessarily represent the decisions, policy or views of the WHO. EDAT- 2025/06/26 00:27 MHDA- 2025/06/26 00:28 PMCR- 2025/06/25 CRDT- 2025/06/25 21:32 PHST- 2024/10/02 00:00 [received] PHST- 2025/06/06 00:00 [accepted] PHST- 2025/06/26 00:28 [medline] PHST- 2025/06/26 00:27 [pubmed] PHST- 2025/06/25 21:32 [entrez] PHST- 2025/06/25 00:00 [pmc-release] AID - bmjgh-2024-017785 [pii] AID - 10.1136/bmjgh-2024-017785 [doi] PST - epublish SO - BMJ Glob Health. 2025 Jun 25;10(6):e017785. doi: 10.1136/bmjgh-2024-017785. PMID- 40562335 OWN - NLM STAT- MEDLINE DCOM- 20250723 LR - 20250723 IS - 1873-3492 (Electronic) IS - 0009-8981 (Linking) VI - 577 DP - 2025 Sep 1 TI - Validation and generation of age-specific reference intervals for a new blood neurofilament light chain assay. PG - 120447 LID - S0009-8981(25)00326-2 [pii] LID - 10.1016/j.cca.2025.120447 [doi] AB - BACKGROUND: Neurofilament light chain (NfL) is the first blood biomarker for multiple sclerosis (MS) with utility for prognosis and disease monitoring. The Simoa NF-light is a research-based assay and is the most highly cited NfL method available, however development of assays specifically designed for routine clinical laboratories are necessary for clinical adoption. The Roche Elecsys NfL assay was developed specifically for routine laboratory use. METHODS: Specimens from 718 MS patients, paired serum-plasma and plasma-CSF specimens were used to compare the Simoa and Elecsys assays. Elecsys NfL precision, linearity, parallelism, limit-of-quantitation and interferences were assessed. RESULTS: Elecsys precision ranged from 1.8 % to 7.3 % coefficient of variation. Serum samples showed a high correlation (Pearson's r = 0.991) with a mean bias of -85.1 % compared to Simoa. Plasma-CSF correlations were high (Pearson's r = 0.993), with CSF values 54.8-fold higher than plasma. Age-specific 97.5th percentile reference limits were generated by transforming Elecsys to Simoa NfL values. The previously developed Simoa NfL reference app was extended to the Elecsys platform using the transformed Simoa reference values to provide age and BMI-adjusted Z scores and percentiles. CONCLUSIONS: The Elecsys NfL assay demonstrated precision and accuracy acceptable for use in clinical laboratories. The Elecsys assay generates NfL concentrations numerically lower than Simoa, however the results are highly correlated, requiring the need for Elecsys-specific reference values. CI - Copyright (c) 2025 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Booth, Ronald A AU - Booth RA AD - Pathology and Laboratory Medicine, University of Ottawa, The Ottawa Hospital & Eastern Ontario Regional Laboratory Association, Ottawa, ON, Canada. Electronic address: rbooth@uottawa.ca. FAU - Beriault, Daniel AU - Beriault D AD - Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. FAU - Schneider, Raphael AU - Schneider R AD - Department of Medicine, Neurology, St Michael's Hospital, Toronto, ON, Canada. FAU - Benkert, Pascal AU - Benkert P AD - Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience (RC2NB), Departments of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland. FAU - Willemse, Eline A J AU - Willemse EAJ AD - Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience (RC2NB), Departments of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland. FAU - Maceski, Aleksandra Maleska AU - Maceski AM AD - Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience (RC2NB), Departments of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland. FAU - Leppert, David AU - Leppert D AD - Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience (RC2NB), Departments of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland. FAU - Freedman, Mark S AU - Freedman MS AD - University of Ottawa, Department of Medicine, Neurology and the Ottawa Hospital Research Institute, Ottawa, ON, Canada. FAU - Kuhle, Jens AU - Kuhle J AD - Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience (RC2NB), Departments of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland. LA - eng PT - Journal Article PT - Validation Study DEP - 20250623 PL - Netherlands TA - Clin Chim Acta JT - Clinica chimica acta; international journal of clinical chemistry JID - 1302422 RN - 0 (Neurofilament Proteins) RN - 0 (neurofilament protein L) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Neurofilament Proteins/blood/cerebrospinal fluid MH - Male MH - Reference Values MH - Female MH - Adult MH - Middle Aged MH - Young Adult MH - Aged MH - Multiple Sclerosis/blood MH - Biomarkers/blood MH - Age Factors MH - Adolescent OTO - NOTNLM OT - Biomarkers OT - Method validation OT - Neurofilament light chain OT - Reference intervals OT - Z score COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/06/26 00:27 MHDA- 2025/07/24 00:25 CRDT- 2025/06/25 19:15 PHST- 2024/11/07 00:00 [received] PHST- 2025/05/28 00:00 [revised] PHST- 2025/06/22 00:00 [accepted] PHST- 2025/07/24 00:25 [medline] PHST- 2025/06/26 00:27 [pubmed] PHST- 2025/06/25 19:15 [entrez] AID - S0009-8981(25)00326-2 [pii] AID - 10.1016/j.cca.2025.120447 [doi] PST - ppublish SO - Clin Chim Acta. 2025 Sep 1;577:120447. doi: 10.1016/j.cca.2025.120447. Epub 2025 Jun 23. PMID- 40561078 OWN - NLM STAT- MEDLINE DCOM- 20250625 LR - 20260924 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 6 DP - 2025 TI - Validating self-administration as an agile modality for high-frequency diet quality data collection. PG - e0317611 LID - 10.1371/journal.pone.0317611 [doi] LID - e0317611 AB - Data collection of diet quality is important to estimate global dietary transitions affecting public health. Mobile-phone based tools can provide a low-cost and rapidly deployable modality to complement enumerator-collected data. This study validated self-administration of the Diet Quality Questionnaire using mobile phones, comparing accuracy against enumerator administration, measuring both against an observed benchmark. Quantitative dietary intake data were gathered from 308 participants in northwest Rwanda, using a weighed food record. Intake data were used to calculated 'observed' responses to the questionnaire, half the participants responding to enumerators, and the other half using a mobile-administered version of the questionnaire. After filtering for low quality data, agreement in observed and reported responses, for all questionnaire questions, were statistically compared. Agreement rates (observed-reported) of self-administered and enumerated responses were high (91% vs 95%, p = 0.05), respectively. Agreement was significantly lower for the mobile-administered modality among older and lower income respondents (by about 5 percentage points), with no significant differences by gender or time of response. Mobile-administration cost approximately USD 0.70 per response, versus the marginal cost of USD 0.79 for the enumerator-administered. Our results confirm self-administered reporting by mobile-phone as a valid, low-cost method for collecting dietary data, with only marginal (yet significant for some subgroups) differences in agreement rates, compared to enumerated data. Data collection by mobile phone represents an agile complement to enumerated collection, administrable in the absence of existing survey platforms; and provides a useful option for high-frequency data collection to monitor dietary dynamics in target sub-populations. CI - Copyright: (c) 2025 Manners et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Manners, Rhys AU - Manners R AUID- ORCID: 0009-0008-7779-2348 AD - International Institute of Tropical Agriculture, Kigali, Rwanda. FAU - Herforth, Anna W AU - Herforth AW AUID- ORCID: 0000-0002-6079-9374 AD - Division of Human Nutrition and Health, Wageningen University and Research (WUR), the Netherlands. FAU - Delfine, Maria AU - Delfine M AD - Division of Human Nutrition and Health, Wageningen University and Research (WUR), the Netherlands. FAU - Hesen, Rosil AU - Hesen R AD - Division of Human Nutrition and Health, Wageningen University and Research (WUR), the Netherlands. FAU - Nkubito, Didier AU - Nkubito D AD - Strategic Development and Research Group, Kigali, Rwanda. FAU - den Berg, Karin Borgonjen-van AU - den Berg KB AD - Division of Human Nutrition and Health, Wageningen University and Research (WUR), the Netherlands. FAU - Matsiko, Eric AU - Matsiko E AD - University of Rwanda, Kigali, Rwanda. FAU - Niyibituronsa, Marguerite AU - Niyibituronsa M AD - Rwanda Agriculture and Animal Resources Development Board (RAB). FAU - Uyar, Betul T M AU - Uyar BTM AD - Division of Human Nutrition and Health, Wageningen University and Research (WUR), the Netherlands. FAU - Talsma, Elise F AU - Talsma EF AD - Division of Human Nutrition and Health, Wageningen University and Research (WUR), the Netherlands. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250625 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Middle Aged MH - *Diet MH - Cell Phone MH - Surveys and Questionnaires MH - Young Adult MH - *Diet Surveys/methods MH - Diet Records MH - *Self Administration MH - Aged MH - *Data Collection/methods MH - Adolescent PMC - PMC12193772 COIS- The authors have declared that no competing interests exist. EDAT- 2025/06/25 18:28 MHDA- 2025/06/25 18:29 PMCR- 2025/06/25 CRDT- 2025/06/25 14:14 PHST- 2024/08/13 00:00 [received] PHST- 2025/05/31 00:00 [accepted] PHST- 2025/06/25 18:29 [medline] PHST- 2025/06/25 18:28 [pubmed] PHST- 2025/06/25 14:14 [entrez] PHST- 2025/06/25 00:00 [pmc-release] AID - PONE-D-24-33268 [pii] AID - 10.1371/journal.pone.0317611 [doi] PST - epublish SO - PLoS One. 2025 Jun 25;20(6):e0317611. doi: 10.1371/journal.pone.0317611. eCollection 2025. PMID- 40561051 OWN - NLM STAT- MEDLINE DCOM- 20250625 LR - 20260928 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 6 DP - 2025 TI - Responses of candidate intensity measures to different mental and motor load levels using upper limb exergames in typically developing children and adolescents. PG - e0326371 LID - 10.1371/journal.pone.0326371 [doi] LID - e0326371 AB - BACKGROUND: In (pediatric) neurorehabilitation, high-intensity therapy is well-recognized for enhancing rehabilitative outcomes. However, measures that consider the different aspects of therapy intensity are lacking. Therefore, a better understanding of how to measure therapy intensity during upper-limb neurorehabilitation is needed. OBJECTIVES: To investigate the response of heart rate variability (HRV), skin conductance (SC), activity counts and movement repetitions normalized for the maximal capacity (%ACmax and %MOVmax, respectively), and the NASA-TLX scale to different mental and motor intensity levels of two self-developed upper limb exergames in typically developing children. We also investigate the effects of age on the responses of the measures. METHODS: In this cross-sectional study, participants engaged in one mental and one motor exergame. For each exergame, they played three personalized intensity levels ("very easy," "challenging," and "very difficult"), each lasting three minutes. We analyzed the responses of all measures for each intensity level and exergame. RESULTS: 21 children and adolescents (9 females) aged 5.2 to 17.9 years participated in the study. HRV, %ACmax, and %MOVmax responded to increased motor intensity. SC did not respond to increases in mental or motor intensity levels. The NASA-TLX responded to increases in motor intensity levels but only partially to increases in mental intensity. Finally, age showed significant effects only on %MOVmax. CONCLUSION: Changes in mental intensity were more challenging to capture than changes in motor intensity. As each measure responded to different aspects of therapy intensity, a combination of measures, e.g., HRV, %ACmax, and NASA-TLX effort, might be the best strategy for assessing therapy intensity multidimensionally. Although the measures hold considerable potential, future studies should determine the responses of the measures and their psychometric properties in the target group. CI - Copyright: (c) 2025 Goikoetxea-Sotelo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Goikoetxea-Sotelo, Gaizka AU - Goikoetxea-Sotelo G AUID- ORCID: 0000-0001-7036-9215 AD - Swiss Children's Rehab, University Children's Hospital Zurich, University of Zurich, Affoltern am Albis, Switzerland. AD - Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland. AD - Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland. FAU - Ratzo, Livia AU - Ratzo L AD - Swiss Children's Rehab, University Children's Hospital Zurich, University of Zurich, Affoltern am Albis, Switzerland. AD - Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland. AD - Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland. FAU - van Hedel, Hubertus J A AU - van Hedel HJA AUID- ORCID: 0000-0002-9577-5049 AD - Swiss Children's Rehab, University Children's Hospital Zurich, University of Zurich, Affoltern am Albis, Switzerland. AD - Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250625 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - Adolescent MH - *Upper Extremity/physiology MH - Heart Rate/physiology MH - Cross-Sectional Studies MH - Child, Preschool MH - *Video Games MH - *Exercise Therapy/methods MH - Galvanic Skin Response/physiology MH - *Neurological Rehabilitation/methods MH - *Exercise/physiology PMC - PMC12193600 COIS- The authors have declared that no competing interests exist. EDAT- 2025/06/25 18:29 MHDA- 2025/06/25 18:30 PMCR- 2025/06/25 CRDT- 2025/06/25 14:13 PHST- 2024/07/22 00:00 [received] PHST- 2025/05/15 00:00 [accepted] PHST- 2025/06/25 18:30 [medline] PHST- 2025/06/25 18:29 [pubmed] PHST- 2025/06/25 14:13 [entrez] PHST- 2025/06/25 00:00 [pmc-release] AID - PONE-D-24-29809 [pii] AID - 10.1371/journal.pone.0326371 [doi] PST - epublish SO - PLoS One. 2025 Jun 25;20(6):e0326371. doi: 10.1371/journal.pone.0326371. eCollection 2025. PMID- 40560408 OWN - NLM STAT- MEDLINE DCOM- 20251204 LR - 20251207 IS - 1439-6327 (Electronic) IS - 1439-6319 (Print) IS - 1439-6319 (Linking) VI - 125 IP - 12 DP - 2025 Dec TI - Measured thoracic gas volume using the bod pod air displacement plethysmography system versus three predictions. PG - 3641-3649 LID - 10.1007/s00421-025-05863-6 [doi] AB - PURPOSE: Bod Pod air displacement plethysmography is a common method to estimate body fat percentage (%BF). To determine body volume from this method, thoracic gas volume (TGV) must be quantified. Measured TGV was compared to three predictions: the default prediction formula in the Bod Pod software from Crapo (CRAPO), a relatively new prediction that relies on height and body mass as the predictors from Ducharme (DUCHARME), and a child-specific formula from Fields (FIELDS). METHODS: University club sport athletes (121 men, 80 women) completed the breathing maneuver in the Bod Pod necessary to obtain measured TGV. Values from the three TGV predictions were compared to measured TGV with a one-way repeated measures ANOVA. Linear regression was used to obtain standard error of estimate (SEE), and Bland-Altman plots were used to evaluate bias. RESULTS: Significant (P < .001) bias exists for all three prediction equations such that individuals with small TGV are overpredicted and those with large TGV are underpredicted. SEEs were similar (0.63-0.66 L) for all three equations. On average, CRAPO and FIELDS underestimated (P < .001) measured TGV by -0.25 L and -0.43 L, respectively, but the difference between DUCHARME and measured TGV (0.07 L) was not significant (P = .813). There were fewer large errors (>/= 2%BF) from DUCHARME (25%) than from CRAPO (31%) or FIELDS (37%). CONCLUSION: TGV should be measured. If it must be predicted, DUCHARME offers a slightly better prediction than CRAPO or FIELDS for young adult athletes, particularly those at the extremes of the TGV continuum. CI - (c) 2025. The Author(s). FAU - Wagner, Dale R AU - Wagner DR AUID- ORCID: 0000-0003-1575-1555 AD - Kinesiology & Health Science Department, Utah State University, 7000 Old Main Hill, Logan, UT, 84322-7000, USA. dale.wagner@usu.edu. FAU - Heath, Edward M AU - Heath EM AD - Kinesiology & Health Science Department, Utah State University, 7000 Old Main Hill, Logan, UT, 84322-7000, USA. FAU - Spencer, Steven AU - Spencer S AD - Kinesiology & Health Science Department, Utah State University, 7000 Old Main Hill, Logan, UT, 84322-7000, USA. FAU - Evans, Alyssa AU - Evans A AD - Nutrition, Dietetics & Food Sciences, Utah State University, Logan, UT, USA. FAU - McBride, Jacob AU - McBride J AD - Kinesiology & Health Science Department, Utah State University, 7000 Old Main Hill, Logan, UT, 84322-7000, USA. FAU - Burch, Tate AU - Burch T AD - Kinesiology & Health Science Department, Utah State University, 7000 Old Main Hill, Logan, UT, 84322-7000, USA. LA - eng PT - Journal Article DEP - 20250625 PL - Germany TA - Eur J Appl Physiol JT - European journal of applied physiology JID - 100954790 SB - IM MH - Humans MH - Male MH - Female MH - *Plethysmography/methods MH - Adult MH - Young Adult MH - Adolescent PMC - PMC12678516 OTO - NOTNLM OT - Athlete OT - Body composition OT - Body volume OT - Lung volume OT - Validity COIS- Declarations. Conflict of interest: The authors have no competing interests to declare that are relevant to the content of this article. Ethical approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Institutional Review Board at Utah State University (protocol # 12253). Consent to participate: Informed consent was obtained from all individual participants included in the study. EDAT- 2025/06/25 12:28 MHDA- 2025/12/04 13:38 PMCR- 2025/06/25 CRDT- 2025/06/25 11:14 PHST- 2024/12/05 00:00 [received] PHST- 2025/06/12 00:00 [accepted] PHST- 2025/12/04 13:38 [medline] PHST- 2025/06/25 12:28 [pubmed] PHST- 2025/06/25 11:14 [entrez] PHST- 2025/06/25 00:00 [pmc-release] AID - 10.1007/s00421-025-05863-6 [pii] AID - 5863 [pii] AID - 10.1007/s00421-025-05863-6 [doi] PST - ppublish SO - Eur J Appl Physiol. 2025 Dec;125(12):3641-3649. doi: 10.1007/s00421-025-05863-6. Epub 2025 Jun 25. PMID- 40560122 OWN - NLM STAT- MEDLINE DCOM- 20251025 LR - 20251025 IS - 1879-3479 (Electronic) IS - 0020-7292 (Linking) VI - 171 IP - 2 DP - 2025 Nov TI - Evaluating serum anti-Mullerian hormone as a diagnostic biomarker for polycystic ovary syndrome in Pakistani women. PG - 676-683 LID - 10.1002/ijgo.70240 [doi] AB - BACKGROUND: Polycystic ovarian syndrome (PCOS) is one of the most common endocrine disorders. Its prevalence varies depending on the criteria used for diagnosis. According to National Institutes of Health, a U.S. government agency responsible for biomedical and public health research, criteria, it affects 6%-10% of women; according to the Rotterdam criteria, it affects 14%-17% of women of childbearing age. Clinically, it can present with oligo/anovulation, infertility, hyperandrogenism, obesity, insulin resistance, and long-term consequences, including metabolic syndrome, type 2 diabetes mellitus, cardiovascular dysfunction, and endometrial cancer. Diagnosing PCOS is challenging due to the lack of unified criteria. According to the Rotterdam criteria, a diagnosis requires at least two of the following three features: Oligo/anovulation Hyperandrogenism (HA) Polycystic ovaries (PCOM), defined as 12 or more follicles measuring 2-9 mm in diameter or an ovarian volume greater than 10 mL. Anti-Mullerian hormone (AMH), also known as Mullerian inhibiting substance (MIS), is produced by granulosa cells of pre-antral and small antral follicles. Its levels vary by age, with low levels until age 8, a sharp rise until age 25, and a steady decline from age 25 to menopause when its production nearly ceases. AMH levels are 2-3 times higher in women with PCOS. Because AMH levels positively correlate with PCOM and androgen levels, they might serve as a reasonable alternative to PCOM on pelvic ultrasound for diagnosing PCOS. AIMS AND OBJECTIVES: This study aimed to evaluate the diagnostic performance of AMH in women aged 18-40 years with PCOS in Pakistan and to compare its utility with PCOM based on the Rotterdam criteria. METHODOLOGY: This quantitative study was conducted at Isra University, Karachi, from June 2023 to June 2024. Data were collected from 100 participants clinically diagnosed with PCOS. Exclusion criteria included women younger than 18 or older than 40 years, those with PCOS-related infertility, or those with a history of ovarian surgery or recent hormonal treatments. Serum AMH levels were measured using ELISA kits, and statistical analyses were performed to assess correlations between AMH, PCOM, age, body mass index (BMI), and other variables. RESULTS: Anti-Mullerian hormone levels showed a significant positive correlation with PCOM (P < 0.0001), confirming its reliability as a diagnostic marker for PCOS. No significant associations were found between AMH and age (P = 0.824), BMI (P = 0.933), or other confounders. No significant association was found between AMH and confounders including age, BMI, and free androgen index (FAI). CONCLUSION: The study demonstrates the high diagnostic reliability of AMH in PCOS, even in resource-limited settings. AMH might serve as a practical diagnostic option in the absence of ultrasound, particularly in settings where imaging access is limited and costly. However, its cost-effectiveness should be evaluated in local clinical contexts. CI - (c) 2025 International Federation of Gynecology and Obstetrics. FAU - Dileep, Anita AU - Dileep A AUID- ORCID: 0009-0000-5531-8401 AD - Dubai Health, Isra University, Karachi, Pakistan. FAU - Saeed, Saira AU - Saeed S AD - Isra University, Karachi, Pakistan. LA - eng PT - Journal Article DEP - 20250625 PL - United States TA - Int J Gynaecol Obstet JT - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics JID - 0210174 RN - 80497-65-0 (Anti-Mullerian Hormone) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - *Polycystic Ovary Syndrome/diagnosis/blood MH - *Anti-Mullerian Hormone/blood MH - Adult MH - Biomarkers/blood MH - Young Adult MH - Pakistan MH - Adolescent MH - Hyperandrogenism/blood OTO - NOTNLM OT - Rotterdam criteria OT - anti-Mullerian hormone (AMH) OT - diagnostic biomarkers OT - low-income settings OT - polycystic ovarian morphology (PCOM) OT - polycystic ovary syndrome (PCOS) OT - south Asian women EDAT- 2025/06/25 12:28 MHDA- 2025/10/25 12:30 CRDT- 2025/06/25 10:33 PHST- 2025/04/15 00:00 [revised] PHST- 2025/01/21 00:00 [received] PHST- 2025/05/13 00:00 [accepted] PHST- 2025/10/25 12:30 [medline] PHST- 2025/06/25 12:28 [pubmed] PHST- 2025/06/25 10:33 [entrez] AID - 10.1002/ijgo.70240 [doi] PST - ppublish SO - Int J Gynaecol Obstet. 2025 Nov;171(2):676-683. doi: 10.1002/ijgo.70240. Epub 2025 Jun 25. PMID- 40557459 OWN - NLM STAT- MEDLINE DCOM- 20260618 LR - 20260618 IS - 2035-648X (Electronic) IS - 1591-996X (Linking) VI - 27 IP - 2 DP - 2026 Jun 10 TI - Translational insights into diet consistency, masticatory efficiency, and posterior crossbite: potential implications for craniofacial development and general health. PG - 121-126 LID - 10.23804/ejpd.2025.2403 [doi] AB - AIM: To evaluate the association between dietary consistency, masticatory patterns, and the presence of posterior crossbite in growing patients, and to explore potential preventive strategies. BACKGROUND: Maxillary constriction, frequently associated with posterior crossbite, presents challenges to craniofacial development. Modern dietary habits, characterised by softer food textures, reduce masticatory demand, potentially contributing to maxillary hypoplasia. However, the translational impact of dietary consistency on general health and craniofacial development remains underexplored. METHODS: A case-control study was conducted with 106 participants divided into two groups: case (posterior crossbite) and control (non-crossbite). Dietary habits were assessed through a validated questionnaire that categorised foods by consistency. Masticatory cycles were analysed using a kinesiograph to identify normal, reverse, and atypical patterns. Statistical analyses included chi-square tests and regression models, with significance set at p < 0.05. CONCLUSION: This study confirms a significant association between dietary consistency, masticatory patterns, and posterior crossbite. The findings underscore the role of dietary texture in craniofacial development, highlighting the importance of preventive dietary strategies to support both craniofacial growth and general health. Further longitudinal studies are recommended to validate these findings and guide translational orthodontic interventions. FAU - Lanteri, V AU - Lanteri V AD - Surgical, Medical and Dental Department, University of Modena and Reggio Emilia, 41124 Modena, Italy. FAU - Abate, A AU - Abate A AD - Department of Sciences Integrated Surgical and Diagnostic, University of Genova, 16126 Genova, Italy. FAU - Bruni, A AU - Bruni A AD - Surgical, Medical and Dental Department, University of Modena and Reggio Emilia, 41124 Modena, Italy. FAU - Bellesia, S AU - Bellesia S AD - Surgical, Medical and Dental Department, University of Modena and Reggio Emilia, 41124 Modena, Italy. FAU - Bellini, P AU - Bellini P AD - Surgical, Medical and Dental Department, University of Modena and Reggio Emilia, 41124 Modena, Italy. FAU - Ugolini, A AU - Ugolini A AD - Department of Sciences Integrated Surgical and Diagnostic, University of Genova, 16126 Genova, Italy. LA - eng PT - Journal Article DEP - 20250601 PL - Italy TA - Eur J Paediatr Dent JT - European journal of paediatric dentistry JID - 101121881 SB - IM MH - Humans MH - *Malocclusion/physiopathology/etiology MH - *Mastication/physiology MH - Female MH - Case-Control Studies MH - Male MH - Child MH - *Diet MH - *Feeding Behavior MH - *Maxillofacial Development MH - Surveys and Questionnaires EDAT- 2025/06/25 06:25 MHDA- 2026/06/18 12:33 CRDT- 2025/06/25 04:44 PHST- 2026/06/18 12:33 [medline] PHST- 2025/06/25 06:25 [pubmed] PHST- 2025/06/25 04:44 [entrez] AID - 10.23804/ejpd.2025.2403 [doi] PST - ppublish SO - Eur J Paediatr Dent. 2026 Jun 10;27(2):121-126. doi: 10.23804/ejpd.2025.2403. Epub 2025 Jun 1. PMID- 40556079 OWN - NLM STAT- MEDLINE DCOM- 20260521 LR - 20260521 IS - 1941-2452 (Electronic) IS - 0884-5336 (Linking) VI - 41 IP - 3 DP - 2026 Jun TI - Interinstrument agreement of hand dynamometer measurement in hospitalized children. PG - 946-951 LID - 10.1002/ncp.11345 [doi] AB - BACKGROUND: Handgrip is a simple and useful parameter used in the diagnosis and follow-up of nutrition disorders and a prognostic indicator for health status. However, data on the measurement of handgrip strength in the pediatric population are limited. The aim of this study was to investigate the inter-instrument agreement and validity of commonly used hand dynamometers in hospitalized children. METHODS: This is a cross-sectional study comparing handgrip strength measurement with Jamar and Takei dynamometers in hospitalized children aged 6-16 years. Intraclass correlations, Pearson correlation, and Bland-Altman analyses were used to assess validity as the level of agreement between devices. RESULTS: Twenty-nine children with a median age of 9 years, 62.1% of whom were male, with metabolic-endocrine and infectious diseases as the main reason for hospital admission were included in the study. The intraclass correlations values between the two devices are 0.928 and 0.872 in the dominant and nondominant hands, respectively. Handgrip strength measured with Takei was greater than Jamar for both the dominant and nondominant hands (P < 0.001) per Bland-Altman analysis. CONCLUSION: Our results show that despite good or excellent reliability, there is poor agreement between devices, indicating a lack of validity. There is a need for improved methods and standardization specific to this population for the use of handgrip strength in pediatric hospitalized patients. CI - (c) 2025 American Society for Parenteral and Enteral Nutrition. FAU - Kangalgil, Melda AU - Kangalgil M AUID- ORCID: 0000-0003-2868-8903 AD - Department of Nutrition and Dietetics, Sivas Cumhuriyet University, Sivas, Turkey. FAU - Meral, Buket AU - Meral B AD - Child Health and Diseases Nursing, Karadeniz Technical University, Trabzon, Turkey. FAU - Tiryaki, Bugra Kaan AU - Tiryaki BK AD - Computer Science, Karadeniz Technical University, Trabzon, Turkey. LA - eng PT - Comparative Study PT - Journal Article DEP - 20250624 PL - United States TA - Nutr Clin Pract JT - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JID - 8606733 SB - IM MH - Humans MH - Child MH - *Hand Strength/physiology MH - Male MH - Cross-Sectional Studies MH - Female MH - *Muscle Strength Dynamometer/standards MH - Adolescent MH - Reproducibility of Results MH - *Child, Hospitalized MH - Hospitalization OTO - NOTNLM OT - body composition OT - handgrip strength OT - muscle strength OT - nutrition assessment OT - pediatrics EDAT- 2025/06/25 06:25 MHDA- 2026/05/21 12:38 CRDT- 2025/06/25 00:23 PHST- 2025/04/23 00:00 [revised] PHST- 2025/02/12 00:00 [received] PHST- 2025/06/03 00:00 [accepted] PHST- 2026/05/21 12:38 [medline] PHST- 2025/06/25 06:25 [pubmed] PHST- 2025/06/25 00:23 [entrez] AID - 10.1002/ncp.11345 [doi] PST - ppublish SO - Nutr Clin Pract. 2026 Jun;41(3):946-951. doi: 10.1002/ncp.11345. Epub 2025 Jun 24. PMID- 40555566 OWN - NLM STAT- MEDLINE DCOM- 20251216 LR - 20251216 IS - 1873-4898 (Electronic) IS - 1477-5131 (Linking) VI - 21 IP - 6 DP - 2025 Dec TI - Comparision of scoring systems in the success of retrograde intrarenal surgery and factors affecting the presence of residual fragments in pediatric patients. PG - 1426-1432 LID - S1477-5131(25)00316-X [pii] LID - 10.1016/j.jpurol.2025.06.011 [doi] AB - INTRODUCTION: The incidence of kidney stones in the pediatric period is increasing and nearly half of patients have recurrence within the first three years. For kidney stone treatment, a range of scoring systems have been defined with preoperative rating based on computed tomography (CT) and some clinical parameters. Different scoring systems entered the literature for retrograde intrarenal surgery (RIRS). Scoring systems were designed mostly for adult patients and though still used, their efficacy and reliability has not been sufficiently researched for the pediatric population. OBJECTIVE: This study aimed to evaluate the effectiveness and reliability of six different scoring systems in our pediatric patient group and to identify the factors affecting the presence of stone fragments after RIRS. METHOD: Patient and stone-related parameters included age, body mass index (BMI), e-GFR, stone localization, stone length, stone volume, density, presence of stones in the lower pole, infundibulopelvic angle (IPA) and renal infundibular length (RIL). Regarding the operation, time, use of ureteral access sheath (UAS), residual stones, preoperative ureteral stent, hospitalization time and developing complications were recorded. Patients were monitored radiologically for residual fragments on the postoperative 1st day kidney ureter bladder (KUB)X ray and 1st month KUB and ultrasonography. Using stone and operative characteristics, appropriate scoring for each patient was performed using six separate scoring systems (R.I.R.Sc, RUSS, S-ReSC, S.T.O.N.E, ITO, T.O.HO). RESULTS: The study included a total of 92 patients. 78 (84.7 %) patients were stone-free, while 14 (15.3 %) patients had residual Stones. The mean stone size was 11.3 +/- 3.5 mm in the stone-free group and 16.4 +/- 5.8 mm in the residual stone group (p = 0.001). In univariate analysis, significant associations were found between residual stone presence and stone complexity (OR: 16.712, p < 0.001), stone diameter (OR: 1.269, p < 0.001), RIRS score (OR: 3.453, p < 0.001), RUSS score (OR: 3.240, p = 0.010), ITO score (OR: 1.392, p < 0.001), STONE score (OR: 1.669, p = 0.003), and TOHO score (OR: 1.459, p = 0.010). In multivariate analysis, stone complexity (OR: 8.240, p = 0.007) and R.I.R.Sc (OR: 2.635, p = 0.004) were identified as independent predictive factors. CONCLUSIONS: Except for the modified S-ReSC system, all other scoring systems were effective in predicting stone-free rate. The R.I.R.Sc system and stone complexity emerged as significant predictors of residual stone presence. CI - Copyright (c) 2025 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved. FAU - Alma, Ergun AU - Alma E AD - Department of Urology, Health Sciences University, Adana City Training and Research Hospital, Adana, Turkey. Electronic address: almaerim@yahoo.com. FAU - Altunkol, Adem AU - Altunkol A AD - Department of Urology, Health Sciences University, Adana City Training and Research Hospital, Adana, Turkey. Electronic address: ademaltunkol@hotmail.com. FAU - Anil, Hakan AU - Anil H AD - Department of Urology, Istanbul Aydin University, Istanbul, Turkey. Electronic address: hakananil@aydin.edu.tr. FAU - Karkin, Kadir AU - Karkin K AD - Department of Urology, Health Sciences University, Adana City Training and Research Hospital, Adana, Turkey. Electronic address: kkadir_karkin@msn.com. FAU - Arslan, Okan AU - Arslan O AD - Department of Urology, Health Sciences University, Adana City Training and Research Hospital, Adana, Turkey. Electronic address: doktorokan03@gmail.com. FAU - Aydamirov, Mubariz AU - Aydamirov M AD - Department of Urology, Baskent University Alanya Application and Research Center, Antalya, Turkey. Electronic address: aydemirov.89@mail.ru. FAU - Sagmak, Burak AU - Sagmak B AD - Department of Urology, Health Sciences University, Adana City Training and Research Hospital, Adana, Turkey. Electronic address: drburaksagmak@hotmail.com. FAU - Deniz, Mehmet Eflatun AU - Deniz ME AD - Department of Urology, Baskent University, Adana Dr Turgut Noyan Education and Research Hospital, Adana, Turkey. Electronic address: eflatun7@gmail.com. FAU - Egilmez, Tulga AU - Egilmez T AD - Department of Urology, Baskent University, Adana Dr Turgut Noyan Education and Research Hospital, Adana, Turkey. Electronic address: tulgaegilmez@yahoo.com. LA - eng PT - Comparative Study PT - Journal Article DEP - 20250611 PL - England TA - J Pediatr Urol JT - Journal of pediatric urology JID - 101233150 SB - IM MH - Humans MH - *Kidney Calculi/surgery/diagnostic imaging/diagnosis MH - Male MH - Female MH - Child MH - Child, Preschool MH - Retrospective Studies MH - Adolescent MH - Treatment Outcome MH - Reproducibility of Results MH - *Urologic Surgical Procedures/methods MH - Tomography, X-Ray Computed OTO - NOTNLM OT - Classification systems OT - Pediatric RIRS OT - Retrograde intrarenal surgery OT - Stone dissease COIS- Conflict of interest The authors declare no competing financial or personal interests. EDAT- 2025/06/25 00:28 MHDA- 2025/12/16 06:28 CRDT- 2025/06/24 21:52 PHST- 2025/03/25 00:00 [received] PHST- 2025/05/10 00:00 [revised] PHST- 2025/06/09 00:00 [accepted] PHST- 2025/12/16 06:28 [medline] PHST- 2025/06/25 00:28 [pubmed] PHST- 2025/06/24 21:52 [entrez] AID - S1477-5131(25)00316-X [pii] AID - 10.1016/j.jpurol.2025.06.011 [doi] PST - ppublish SO - J Pediatr Urol. 2025 Dec;21(6):1426-1432. doi: 10.1016/j.jpurol.2025.06.011. Epub 2025 Jun 11. PMID- 40555198 OWN - NLM STAT- MEDLINE DCOM- 20251006 LR - 20251006 IS - 1421-9832 (Electronic) IS - 1018-8665 (Linking) VI - 241 IP - 4 DP - 2025 TI - Food Insecurity in Hidradenitis Suppurativa: A Cross-Sectional Analysis from the Population-Based All of Us Research Program. PG - 405-409 LID - 10.1159/000546500 [doi] AB - BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory cutaneous disease associated with obesity and low socioeconomic status that can have a significant impact on quality of life. Food insecurity (FI) is associated with a higher likelihood of having a chronic health condition. This cross-sectional study was undertaken to assess the association between HS and FI. SUMMARY: We performed secondary analysis of a cross-sectional survey of individuals 18 years and older registered in the National Institutes of Health's All of Us Research Program in May 2024. The study sample was limited to those who had completed the Children's HealthWatch Hunger Vital Sign FI screening survey, validated for use in adults in 2017. HS status was assessed among study participants based on ICD-9/10 diagnosis code (705.83 or L73.2). Multivariable logistic regression was used to characterize the association between HS diagnosis and food security status, adjusting for sex, race and ethnicity, age, and income. Among participants with HS, 37/134 (27.6%) screened positive for FI. In comparison, among those without HS, 6,278/56,967 (11%) screened positive. In an adjusted multivariable logistic regression, HS was associated with significantly higher odds of FI (OR: 1.70, 95% CI: 1.09-2.60). KEY MESSAGES: Study results demonstrated a significant association between HS and FI. Further research is needed to understand specific factors mediating the relationship between HS and FI. The study highlights an opportunity for dermatologists to take an active role in screening for FI in patients with HS and in providing resources as necessary. CI - (c) 2025 S. Karger AG, Basel. FAU - Jain, Shivani AU - Jain S AD - Louisiana State University Health Sciences Center-New Orleans School of Medicine, New Orleans, Louisiana, USA, sjain7@lsuhsc.edu. FAU - Gunasti, Jonathan AU - Gunasti J AD - Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, USA. FAU - Sood, Aditya AU - Sood A AD - Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, USA. FAU - Dieudonne, Ryan AU - Dieudonne R AD - Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA. FAU - Chopra, Divya AU - Chopra D AD - Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA. FAU - Lev-Tov, Hadar AU - Lev-Tov H AD - Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA. FAU - Yeung, Howa AU - Yeung H AD - Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, USA. FAU - Orenstein, Lauren A V AU - Orenstein LAV AD - Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, USA. LA - eng PT - Journal Article PT - Review DEP - 20250624 PL - Switzerland TA - Dermatology JT - Dermatology (Basel, Switzerland) JID - 9203244 SB - IM MH - Humans MH - *Hidradenitis Suppurativa/epidemiology MH - Cross-Sectional Studies MH - Male MH - *Food Insecurity MH - Female MH - Adult MH - United States/epidemiology MH - Middle Aged MH - Young Adult MH - Adolescent OTO - NOTNLM OT - All of Us OT - Food insecurity OT - Hidradenitis OT - Hidradenitis suppurativa OT - Quality of life OT - Social determinants of health EDAT- 2025/06/25 00:27 MHDA- 2025/10/06 18:31 CRDT- 2025/06/24 18:22 PHST- 2024/09/17 00:00 [received] PHST- 2025/05/10 00:00 [accepted] PHST- 2025/10/06 18:31 [medline] PHST- 2025/06/25 00:27 [pubmed] PHST- 2025/06/24 18:22 [entrez] AID - 000546500 [pii] AID - 10.1159/000546500 [doi] PST - ppublish SO - Dermatology. 2025;241(4):405-409. doi: 10.1159/000546500. Epub 2025 Jun 24. PMID- 40553682 OWN - NLM STAT- MEDLINE DCOM- 20260805 LR - 20260806 IS - 2168-2208 (Electronic) IS - 2168-2194 (Linking) VI - 30 IP - 8 DP - 2026 Aug TI - A Machine Learning Analysis of Physiological Monitoring Signals to Detect Small Airway Narrowing Due to Cold Air Exposure in Asthma. PG - 7255-7263 LID - 10.1109/JBHI.2025.3582739 [doi] AB - Asthma is a chronic inflammatory disease of the small airways, affecting over 200 million people globally. Cold air exposure is a potential risk factor for asthma exacerbations. We hypothesized that monitoring physiological signals during exposure to cold would help to detect potential worsening in asthma and can be used to help persons with asthma adjust their daily routine. Non-smoker adults (18-80 years) with asthma were asked to sit in a cold room of 0$;\circ $C temperature for 10 minutes. During this period, Electrocardiogram (ECG) and thoraco-abdominal motion/respiration belt signals were measured continuously. At 0 and 10 min, small airway narrowing was assessed with oscillometry to estimate respiratory system impedance. Based on changes in respiratory impedance from 0 to 10 min, participants were grouped into with or without airway narrowing. After signal processing, we extracted time and frequency domain features from ECG and respiration signals. To classify airway narrowing, different machine learning classifiers were fine-tuned and evaluated using a leave-one-subject-out cross-validation approach. A total of 23 individuals (11 females, age: 56.3 $\pm$ 10.9 years, BMI: 27.4 $\pm$ 5.7 kg/m$;2$) with asthma were enrolled in the study. Up to 42% and 58% windows of signals were from individuals with and without airway narrowing, respectively. The support vector machine classifier performed the best compared to other models with an accuracy of 85%, precision of 87%, recall of 76%, specificity of 91%, and F1 score of 81%. These results provided proof of concept that technologies with embedded respiratory and cardiac signal monitoring may be able to predict airway narrowing during exposure to cold air in individuals with asthma. FAU - Chavoshian, Shaghayegh AU - Chavoshian S FAU - Fossat, Yan AU - Fossat Y FAU - Cao, Xiaoshu AU - Cao X FAU - Kaufman, Jaycee AU - Kaufman J FAU - Stanbrook, Matthew B AU - Stanbrook MB FAU - Tarlo, Susan M AU - Tarlo SM FAU - Yadollahi, Azadeh AU - Yadollahi A LA - eng PT - Journal Article PL - United States TA - IEEE J Biomed Health Inform JT - IEEE journal of biomedical and health informatics JID - 101604520 SB - IM MH - Humans MH - Female MH - Middle Aged MH - *Machine Learning MH - Adult MH - *Signal Processing, Computer-Assisted MH - *Asthma/physiopathology/diagnosis MH - Male MH - Aged MH - *Cold Temperature/adverse effects MH - Young Adult MH - Monitoring, Physiologic/methods MH - Aged, 80 and over MH - Adolescent MH - Electrocardiography EDAT- 2025/06/24 18:30 MHDA- 2026/08/05 18:38 CRDT- 2025/06/24 12:43 PHST- 2026/08/05 18:38 [medline] PHST- 2025/06/24 18:30 [pubmed] PHST- 2025/06/24 12:43 [entrez] AID - 10.1109/JBHI.2025.3582739 [doi] PST - ppublish SO - IEEE J Biomed Health Inform. 2026 Aug;30(8):7255-7263. doi: 10.1109/JBHI.2025.3582739. PMID- 40551920 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250625 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 17 IP - 5 DP - 2025 May TI - Recurrence of Obstructive Sleep Apnea in Post-adenotonsillectomy Obese Pediatric Patients: A Systematic Review. PG - e84741 LID - 10.7759/cureus.84741 [doi] LID - e84741 AB - Obstructive sleep apnea (OSA) is an under-recognized consequence of pediatric obesity, with adenotonsillectomy (AT) serving as the standard first-line surgical treatment. In obese pediatric patients, OSA often recurs postoperatively, raising concern for the long-term efficacy of AT. This systematic review evaluates the recurrence of OSA in post-AT obese pediatric patients, with a focus on the key risk factors contributing to residual disease. A literature search was conducted using Embase, PubMed, and Web of Science. Eligibility criteria included peer-reviewed, English articles published within the last five years that contained pediatric patients less than 18 years old who had a body mass index (BMI) >/= 95th percentile. All patients had to have been diagnosed with sleep-disordered breathing or OSA preoperatively and must have undergone AT. Eleven studies met these criteria, of which 82% demonstrated a significant association between obesity and recurrence of OSA following AT. Key factors included higher baseline apnea-hypopnea index, postoperative weight gain, and residual upper airway obstruction. Two studies contradicted this trend, but limitations such as the use of subjective questionnaires and short follow-up durations reduced the studies' reliability. The findings indicate that AT alone is often insufficient in resolving OSA in obese pediatric patients. Given the high recurrence rates, a multidisciplinary approach, including weight management and non-invasive ventilation, may be needed to improve outcomes in this vulnerable population. CI - Copyright (c) 2025, Cohen et al. FAU - Cohen, Adi AU - Cohen A AD - Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Davie, USA. FAU - Gunthner, Andrew AU - Gunthner A AD - Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Davie, USA. FAU - Cervone, Adam AU - Cervone A AD - Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Davie, USA. FAU - Uzwy, Madison AU - Uzwy M AD - Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Davie, USA. FAU - Urban-Galvez, Stephanie N AU - Urban-Galvez SN AD - Pediatrics, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Davie, USA. LA - eng PT - Journal Article PT - Review DEP - 20250524 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC12184734 OTO - NOTNLM OT - adenotonsillectomy OT - obese OT - obstructive sleep apnea OT - pediatrics OT - sleep disordered breathing OT - tonsillectomy COIS- Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2025/06/24 11:09 MHDA- 2025/06/24 11:10 PMCR- 2025/05/24 CRDT- 2025/06/24 04:16 PHST- 2025/04/14 00:00 [received] PHST- 2025/05/24 00:00 [accepted] PHST- 2025/06/24 11:10 [medline] PHST- 2025/06/24 11:09 [pubmed] PHST- 2025/06/24 04:16 [entrez] PHST- 2025/05/24 00:00 [pmc-release] AID - 10.7759/cureus.84741 [doi] PST - epublish SO - Cureus. 2025 May 24;17(5):e84741. doi: 10.7759/cureus.84741. eCollection 2025 May. PMID- 40549386 OWN - NLM STAT- MEDLINE DCOM- 20250624 LR - 20250904 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 8 IP - 6 DP - 2025 Jun 2 TI - Central Precocious Puberty and Psychiatric Disorders. PG - e2516679 LID - 10.1001/jamanetworkopen.2025.16679 [doi] LID - e2516679 AB - IMPORTANCE: Within the physiological range, early pubertal timing is associated with an increased risk of mental health issues. Previous studies examining the associations of central precocious puberty (CPP) with mental health have yielded inconclusive results. OBJECTIVE: To describe the risk for development of psychiatric disorders in patients with CPP and to identify periods during which patients with CPP are at heightened risk of developing psychopathological conditions. DESIGN, SETTING, AND PARTICIPANTS: In this population-based, retrospective cohort study, patients with CPP and matched controls were identified from German health insurance data (approximately 6.5 million individuals) and followed from January 2010 to June 2023. Individuals were included if they had continuous insurance coverage for at least 2 years during the study period. Data were analyzed from July 2024 to March 2025. EXPOSURE: Diagnosis of CPP. MAIN OUTCOMES AND MEASURES: Diagnosis of depression, anxiety disorders, oppositional defiant and conduct disorders (ODD/CD), and attention deficit/hyperactivity disorder (ADHD). Incidence rates for psychiatric disorders before and after the diagnosis of CPP were compared between patients and controls exactly matched for sex, birth year interval, insurance period, and obesity. RESULTS: After the application of validation criteria, 1094 patients with idiopathic CPP (438 born from 2010-2014 [40.0%]; 999 female [91.3%]; 249 [22.8%] with obesity) were identified and compared with 5448 controls (2184 born between 2010-2014 [40.1%]; 4975 female [91.3%]; 1242 with obesity [22.8%]). Compared with controls, patients with CPP were more likely to receive a diagnosis of any mental disorder (270 patients [24.7%] vs 920 controls [16.9%]; adjusted risk ratio [aRR], 1.48; 95% CI, 1.31-1.67), depression (82 patients [7.5%] vs 252 controls [4.6%]; aRR, 1.73; 95% CI, 1.37-2.20), anxiety disorders (88 patients [8.0%] vs 312 controls [5.7%]; aRR, 1.45; 95% CI, 1.16-1.82), ODD/CD (87 patients [8.0%] vs 243 controls [4.5%]; aRR, 1.76; 95% CI, 1.39-2.23), and ADHD (123 patients [11.2%] vs 397 controls [7.3%]; aRR, 1.53; 95% CI, 1.27-1.86). Temporal trends showed increased incidence rates for ODD/CD even before the diagnosis of CPP. For depression and ADHD, incidence rates remained increased for at least 8 years after the initial CPP diagnosis. CONCLUSIONS AND RELEVANCE: In this retrospective cohort study of patients with CPP, CPP was associated with an increased risk of psychiatric disorders, with evidence supporting long-term mental health outcomes, suggesting that caretakers of children with CPP should be vigilant for the emergence of psychiatric symptoms to initiate psychiatric care at an early stage. FAU - Dinkelbach, Lars AU - Dinkelbach L AD - Department of Pediatrics III, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. AD - Institute of Sex- and Gender-Sensitive Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. FAU - Grasemann, Corinna AU - Grasemann C AD - Division of Rare Diseases and Center for Rare Diseases Ruhr, Member of the European Reference Network on Rare Endocrine Conditions, Department of Pediatrics, St Josef-Hospital, Ruhr-University Bochum, Bochum, Germany. FAU - Kiewert, Cordula AU - Kiewert C AD - Division of Pediatric Endocrinology and Diabetes, Member of the European Reference Network on Rare Endocrine Conditions, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. FAU - Leikeim, Lisa AU - Leikeim L AD - Health Data Lab, Gesellschaft fur Wirtschaftlichkeit und Qualitat bei Krankenkassen ServicePlus AG, Dusseldorf, Germany. FAU - Schmidt, Borge AU - Schmidt B AD - Institute of Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. FAU - Hirtz, Raphael AU - Hirtz R AD - Center for Child and Adolescent Medicine, Helios University Hospital Wuppertal, Witten/Herdecke University, Wuppertal, Germany. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250602 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Humans MH - *Puberty, Precocious/epidemiology/psychology/complications MH - Female MH - Male MH - Retrospective Studies MH - Child MH - Germany/epidemiology MH - *Mental Disorders/epidemiology MH - Attention Deficit Disorder with Hyperactivity/epidemiology MH - Case-Control Studies MH - Adolescent MH - Incidence MH - Risk Factors MH - Anxiety Disorders/epidemiology PMC - PMC12186511 COIS- Conflict of Interest Disclosures: Dr Grasemann reported receiving grants from Gemeinsamer Bundesausschuss (GBA; German Federal Funding) outside the submitted work. No other disclosures were reported. EDAT- 2025/06/24 10:48 MHDA- 2025/06/24 18:30 PMCR- 2025/06/23 CRDT- 2025/06/23 11:33 PHST- 2025/06/24 18:30 [medline] PHST- 2025/06/24 10:48 [pubmed] PHST- 2025/06/23 11:33 [entrez] PHST- 2025/06/23 00:00 [pmc-release] AID - 2835471 [pii] AID - zoi250524 [pii] AID - 10.1001/jamanetworkopen.2025.16679 [doi] PST - epublish SO - JAMA Netw Open. 2025 Jun 2;8(6):e2516679. doi: 10.1001/jamanetworkopen.2025.16679. PMID- 40547300 OWN - NLM STAT- MEDLINE DCOM- 20250624 LR - 20250625 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 13 DP - 2025 TI - Prevalence of obesity and associated risk factors among university students using the newly developed Student Lifestyle and Obesity Risk Questionnaire (SLORQ): a cross-sectional study. PG - e19556 LID - 10.7717/peerj.19556 [doi] LID - e19556 AB - BACKGROUND: Obesity is a significant global health challenge, with a rising prevalence among young adults. University students are particularly vulnerable to lifestyle transitions and environmental influences. However, current assessment tools lack comprehensive multidimensional coverage of obesity risk factors, especially tailored to the cultural context of Saudi University students, representing a significant gap this study aims to address. OBJECTIVES: To determine the prevalence of obesity among university students and identify behavioral, environmental, and demographic risk factors contributing to obesity via the Student Lifestyle and Obesity Risk Questionnaire (SLORQ). METHODS: This cross-sectional study was conducted from March to July 2024 and involved 907 students across 11 colleges at Majmaah University. Anthropometric data (height and weight) were objectively measured by the primary author, with students barefoot and wearing minimal clothing. The participants completed a self-reported validated, bilingual questionnaire (SLORQ) assessing six domains: physical activity, dietary habits, sleep patterns, weight management, metabolic health, and environmental factors. Data were analyzed using descriptive statistics (means, standard deviations), chi-square tests for categorical associations, and multiple linear regression for continuous predictors. Structural validity was assessed via principal component analysis (PCA); reliability included Cronbach's alpha (>/= 0.70) and intrarater reliability, intraclass correlation coefficients (ICC). RESULTS: Following data collection, statistical analyses revealed that the prevalence of obesity was 15% (n = 136), with 40% classified as overweight. SLORQ scores revealed inverse relationships between body mass index (BMI) and health behaviors, particularly dietary habits (r = - 0.912, p < 0.001) and physical activity (r = - 0.614, p < 0.001). No significant differences in BMI were observed based on gender, age, or region. Regression analysis indicated that diet, sleep, and physical activity accounted for most of the variance in BMI, highlighting their importance in obesity prevention. The questionnaire's internal consistency (Cronbach's alpha = 0.915) and intrarater reliability (ICC = 0.999) were assessed to ensure validity. CONCLUSION: Obesity among university students at Majmaah University is influenced by poor dietary practices, inadequate physical activity, and insufficient sleep. These findings underscore the need for targeted health promotion campaigns and campus-wide interventions to address modifiable risk factors. The SLORQ has proven effective in assessing multidimensional obesity risk factors and can guide future research and policymaking. CI - (c)2025 Seyam. FAU - Seyam, Mohamed K AU - Seyam MK AD - Department of Physical Therapy and Health Rehabilitation, College of Applied Medical Sciences, Majmaah University, Majmaah, Riyadh, Saudi Arabia. LA - eng PT - Journal Article DEP - 20250618 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Male MH - Universities MH - *Students/statistics & numerical data MH - *Obesity/epidemiology MH - Surveys and Questionnaires MH - Risk Factors MH - Prevalence MH - Young Adult MH - *Life Style MH - Saudi Arabia/epidemiology MH - Adult MH - Reproducibility of Results MH - Exercise MH - Adolescent PMC - PMC12182051 OTO - NOTNLM OT - College students OT - Cross sectional study OT - Domains OT - Obesity OT - Prevalence OT - Questionnaire OT - Risk factors OT - Saudi Arabia COIS- The author declares that they have no competing interests. EDAT- 2025/06/24 10:59 MHDA- 2025/06/24 11:00 PMCR- 2025/06/18 CRDT- 2025/06/23 06:09 PHST- 2025/02/13 00:00 [received] PHST- 2025/05/12 00:00 [accepted] PHST- 2025/06/24 11:00 [medline] PHST- 2025/06/24 10:59 [pubmed] PHST- 2025/06/23 06:09 [entrez] PHST- 2025/06/18 00:00 [pmc-release] AID - 19556 [pii] AID - 10.7717/peerj.19556 [doi] PST - epublish SO - PeerJ. 2025 Jun 18;13:e19556. doi: 10.7717/peerj.19556. eCollection 2025. PMID- 40546825 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250625 IS - 2673-6101 (Electronic) IS - 2673-6101 (Print) IS - 2673-6101 (Linking) VI - 6 DP - 2025 TI - Platelet-to-high-density lipoprotein ratio as a biomarker for asthma risk in adolescents: insights from NHANES 2011-2023. PG - 1593351 LID - 10.3389/falgy.2025.1593351 [doi] LID - 1593351 AB - BACKGROUND: Asthma is a common inflammatory disease among adolescents, with systemic inflammation playing a key role in its development. The platelet-to-high-density lipoprotein ratio (PHR) has emerged as a novel indicator of systemic inflammation. However, while individual roles of platelet count and HDL cholesterol in asthma have been studied, the combined impact of PHR on asthma risk-particularly in adolescent populations-remains unclear and underexplored. OBJECTIVE: This study aimed to evaluate the association between PHR and asthma risk in adolescents using data from the National Health and Nutrition Examination Survey (NHANES) 2011-2023. METHODS: A cross-sectional analysis was conducted on 10,046 adolescents aged 8-18 years from NHANES. Asthma status was self-reported, and PHR was calculated as the ratio of platelet count (1,033 /mul) to HDL cholesterol (mg/dl). Logistic regression models were used to assess the association between PHR quartiles and asthma, adjusting for age, sex, race/ethnicity, body mass index (BMI), and poverty-to-income ratio (PIR). Restricted cubic spline (RCS) analysis was applied to examine non-linear relationships, with sensitivity and subgroup analyses conducted to ensure robustness. RESULTS: Adolescents with asthma had higher PHR levels compared to non-asthmatic peers (p < 0.001). In fully adjusted models, participants in the highest PHR quartile had significantly higher odds of asthma (OR = 1.59, 95% CI: 1.37-1.83, p < 0.001) compared to the lowest quartile. RCS analysis revealed a non-linear relationship, with asthma risk escalating sharply at higher PHR levels. Subgroup analyses confirmed consistent associations across race/ethnicity, BMI, and PIR categories. Sensitivity analyses excluding participants under 12 years of age yielded similar results. CONCLUSION: PHR is significantly associated with asthma risk in adolescents, highlighting its potential as a cost-effective and accessible biomarker for identifying high-risk individuals. These findings underscore the need for further longitudinal and interventional studies to validate PHR's role in asthma prediction and management. CI - (c) 2025 Liao, Lv, Xu, Zan and Xie. FAU - Liao, Fangju AU - Liao F AD - Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. FAU - Lv, Qi AU - Lv Q AD - Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. FAU - Xu, Yana AU - Xu Y AD - Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. FAU - Zan, Jieyu AU - Zan J AD - Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. FAU - Xie, Yu AU - Xie Y AD - Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. LA - eng PT - Journal Article DEP - 20250606 PL - Switzerland TA - Front Allergy JT - Frontiers in allergy JID - 9918227355906676 PMC - PMC12179139 OTO - NOTNLM OT - NHANES OT - adolescents OT - asthma OT - biomarker OT - platelet-to-HDL ratio (PHR) OT - systemic inflammation COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/06/24 10:58 MHDA- 2025/06/24 10:59 PMCR- 2025/06/06 CRDT- 2025/06/23 06:02 PHST- 2025/03/17 00:00 [received] PHST- 2025/05/20 00:00 [accepted] PHST- 2025/06/24 10:59 [medline] PHST- 2025/06/24 10:58 [pubmed] PHST- 2025/06/23 06:02 [entrez] PHST- 2025/06/06 00:00 [pmc-release] AID - 10.3389/falgy.2025.1593351 [doi] PST - epublish SO - Front Allergy. 2025 Jun 6;6:1593351. doi: 10.3389/falgy.2025.1593351. eCollection 2025. PMID- 40544709 OWN - NLM STAT- MEDLINE DCOM- 20250907 LR - 20260524 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 214 DP - 2025 Oct 1 TI - Automated registration of snacking behavior in 3- to 7-year-Old children using SnackBox technology. PG - 108201 LID - S0195-6663(25)00354-X [pii] LID - 10.1016/j.appet.2025.108201 [doi] AB - BACKGROUND: Accurate measurement of children's eating habits is essential for dietary guidance and understanding diet-health relationships. Traditional methods rely on parent reports, which are prone to bias and burdensome. Sensor technologies offer promise for passively capturing children's dietary behaviors. This study evaluates such a sensor, the SnackBox, in children aged 3-7 years at home. METHODS: Forty-three children (23 girls, mean age 5.7 +/- 1.1 years) used the SnackBox with parental assistance. This sensor device has three weighing stations to store snack containers or beverages bottles and automatically measures timing and quantity of consumption. Children's snack vegetable intake (cucumber, carrot, bell pepper) was recorded at home on eight school-day afternoons over four weeks. SnackBox data were compared to pre-weighed portions and post-consumption left overs (gold standard). Time-series data were analyzed to explore snack patterns across children and across different vegetable offering strategies. RESULTS: The SnackBox recorded slightly higher average vegetable intake (111 +/- 56 g) than the reference method (96 +/- 49 g), with a mean error of 12 % (6 g) and mean absolute error of 38 % (28 g). A strong correlation (r(s) = 0.83, p < .001) and good reliability (ICC = 0.83, 95 % CI: 0.79-0.86) were observed. Error increased with higher intake, in younger children, and varied by vegetable. Case study results suggest differences in snacking patterns (e.g., eating duration, breaks, switching behaviors) between children and offering strategies. CONCLUSION: The SnackBox shows promise for measuring snacking behaviors in children with minimal input, though current error rates limit its use for precise intake assessment. With refinement, it could potentially enhance understanding of early dietary habits and support tailored interventions. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - de Gooijer, Femke J AU - de Gooijer FJ AD - Division of Human Nutrition and Health, Department of Agrotechnology and Food Sciences, Wageningen University and Research, P.O. Box 17, Wageningen, 6700 AA, the Netherlands; OnePlanet Research Centre, Bronland 10, Wageningen, 6708 WE, the Netherlands. Electronic address: femke.degooijer@wur.nl. FAU - Lasschuijt, Marlou AU - Lasschuijt M AD - Division of Human Nutrition and Health, Department of Agrotechnology and Food Sciences, Wageningen University and Research, P.O. Box 17, Wageningen, 6700 AA, the Netherlands. Electronic address: marlou.lasschuijt@wur.nl. FAU - Feskens, Edith J M AU - Feskens EJM AD - Division of Human Nutrition and Health, Department of Agrotechnology and Food Sciences, Wageningen University and Research, P.O. Box 17, Wageningen, 6700 AA, the Netherlands. Electronic address: edith.feskens@wur.nl. FAU - Camps, Guido AU - Camps G AD - Division of Human Nutrition and Health, Department of Agrotechnology and Food Sciences, Wageningen University and Research, P.O. Box 17, Wageningen, 6700 AA, the Netherlands; OnePlanet Research Centre, Bronland 10, Wageningen, 6708 WE, the Netherlands. Electronic address: guido.camps@wur.nl. LA - eng PT - Journal Article DEP - 20250621 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Child MH - *Snacks/psychology MH - Female MH - Male MH - Child, Preschool MH - *Feeding Behavior MH - *Child Behavior MH - Vegetables MH - Diet OTO - NOTNLM OT - Children OT - Dietary assessment OT - Snack OT - Technology OT - Vegetables COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/06/23 06:13 MHDA- 2025/09/08 00:32 CRDT- 2025/06/22 18:06 PHST- 2025/02/25 00:00 [received] PHST- 2025/06/17 00:00 [revised] PHST- 2025/06/17 00:00 [accepted] PHST- 2025/09/08 00:32 [medline] PHST- 2025/06/23 06:13 [pubmed] PHST- 2025/06/22 18:06 [entrez] AID - S0195-6663(25)00354-X [pii] AID - 10.1016/j.appet.2025.108201 [doi] PST - ppublish SO - Appetite. 2025 Oct 1;214:108201. doi: 10.1016/j.appet.2025.108201. Epub 2025 Jun 21. PMID- 40542618 OWN - NLM STAT- MEDLINE DCOM- 20260307 LR - 20260724 IS - 1552-6372 (Electronic) IS - 1524-8399 (Linking) VI - 27 IP - 2 DP - 2026 Mar TI - Acquisition and Retention of Pedestrian Safety Knowledge in Elementary and Middle School Students Through the WalkSafe Injury Prevention Program. PG - 239-246 LID - 10.1177/15248399251345379 [doi] AB - Pedestrian injuries and fatalities are pervasive, often preventable, and globally recognized. Road safety is an international, national, and local concern that affects billions of people, particularly those who live in underserved communities and with poor transportation accessibility and road safety infrastructure. Since 2005, the evidence-based WalkSafe pedestrian education program has been implemented annually across elementary public schools. This is the first study conducted on WalkSafe with a focus on knowledge acquisition by elementary students and retention of safety concepts by middle schoolers. Data were collected from a total of 3,621 elementary students at 36 participating schools and 1,112 middle schoolers at 29 middle schools using a student survey. The correct percentage of Kindergarten post- and Grade 3 post-survey responses significantly improved in 10 of the 11 survey items. Middle schoolers (N = 1,112) maintained a high correct percentage in nine of the 11 knowledge survey questions. Results of this study validate previous studies on the effectiveness of WalkSafe on students' pedestrian safety knowledge. Results also indicate that middle schoolers retain safety knowledge once they are no longer exposed to WalkSafe. Practical implications of this study include the significant role of safety school-based interventions in promoting safety knowledge in children through reinforced learning and innovative strategies. Further research is needed on the internalization and transfer of safety knowledge to pedestrian safety attitudes and behaviors in children. National and state policies on and funding for pedestrian school-based safety education should be part of the societal discourse. FAU - Kloosterman, Valentina I AU - Kloosterman VI AUID- ORCID: 0000-0003-4222-5649 AD - University of Miami, Miami, FL, USA. FAU - Gomez, Carolina AU - Gomez C AD - University of Miami, Miami, FL, USA. FAU - Ke, Hengyi AU - Ke H AUID- ORCID: 0000-0002-4854-9882 AD - University of Miami, Miami, FL, USA. FAU - Hotz, Gillian A AU - Hotz GA AD - University of Miami, Miami, FL, USA. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250621 PL - United States TA - Health Promot Pract JT - Health promotion practice JID - 100890609 SB - IM MH - Humans MH - Child MH - *Pedestrians/education MH - *Health Knowledge, Attitudes, Practice MH - *Safety MH - *Accidents, Traffic/prevention & control MH - Male MH - *Walking/injuries MH - Female MH - *Wounds and Injuries/prevention & control MH - *Health Education MH - Schools MH - *Students/psychology MH - *Health Promotion OTO - NOTNLM OT - WalkSafe OT - child safety OT - education OT - health promotion OT - pedestrian safety OT - prevention OT - school-based OT - unintentional injury OT - walking EDAT- 2025/06/21 18:54 MHDA- 2026/03/07 06:39 CRDT- 2025/06/21 05:12 PHST- 2026/03/07 06:39 [medline] PHST- 2025/06/21 18:54 [pubmed] PHST- 2025/06/21 05:12 [entrez] AID - 10.1177/15248399251345379 [doi] PST - ppublish SO - Health Promot Pract. 2026 Mar;27(2):239-246. doi: 10.1177/15248399251345379. Epub 2025 Jun 21. PMID- 40541283 OWN - NLM STAT- MEDLINE DCOM- 20250624 LR - 20250626 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 9 IP - 1 DP - 2025 Jun 19 TI - Machine learning approaches to identify neonates and young children at risk for postdischarge mortality in Dar es Salaam, Tanzania and Monrovia, Liberia. LID - 10.1136/bmjpo-2025-003547 [doi] LID - e003547 AB - BACKGROUND: The time after hospital discharge carries high rates of mortality in neonates and young children in sub-Saharan Africa. Previous work using logistic regression to develop risk assessment tools to identify those at risk for postdischarge mortality has yielded fair discriminatory value. Our objective was to determine if machine learning models would have greater discriminatory value to identify neonates and young children at risk for postdischarge mortality. METHODS: We conducted a planned secondary analysis of a prospective observational cohort at Muhimbili National Hospital in Dar es Salaam, Tanzania and John F. Kennedy Medical Center in Monrovia, Liberia. We enrolled neonates and young children near the time of discharge. The outcome was 60-day postdischarge mortality. We collected socioeconomic, demographic, clinical, and anthropometric data during hospital admission and used machine learning (ie, eXtreme Gradient Boosting (XGBoost), Hist-Gradient Boost, Support Vector Machine, Neural Network, and Random Forest) to develop risk assessment tools to identify: (1) neonates and (2) young children at risk for postdischarge mortality. RESULTS: A total of 2310 neonates and 1933 young children enrolled. Of these, 71 (3.1%) neonates and 67 (3.5%) young children died after hospital discharge. XGBoost, Hist Gradient Boost, and Neural Network models yielded the greatest discriminatory value (area under the receiver operating characteristic curves range: 0.94-0.99) and fewest features, which included six features for neonates and five for young children. Discharge against medical advice, low birth weight, and supplemental oxygen requirement during hospitalisation were predictive of postdischarge mortality in neonates. For young children, discharge against medical advice, pallor, and chronic medical problems were predictive of postdischarge mortality. CONCLUSIONS: Our parsimonious machine learning-based models had excellent discriminatory value to predict postdischarge mortality among neonates and young children. External validation of these tools is warranted to assist in the design of interventions to reduce postdischarge mortality in these vulnerable populations. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Rees, Chris A AU - Rees CA AUID- ORCID: 0009-0005-7268-4346 AD - Division of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, USA chrisrees2@gmail.com. AD - Children's Healthcare of Atlanta, Atlanta, Georgia, USA. FAU - Kisenge, Rodrick AU - Kisenge R AD - Department of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania. FAU - Godfrey, Evance AU - Godfrey E AD - Muhimbili National Hospital, Dar es Salaam, United Republic of Tanzania. FAU - Ideh, Readon C AU - Ideh RC AD - Department of Pediatrics, John F. Kennedy Medical Center, Monrovia, Liberia. FAU - Kamara, Julia AU - Kamara J AD - Department of Pediatrics, John F. Kennedy Medical Center, Monrovia, Liberia. FAU - Coleman-Nekar, Ye-Jeung G AU - Coleman-Nekar YG AD - Department of Pediatrics, John F. Kennedy Medical Center, Monrovia, Liberia. FAU - Samma, Abraham AU - Samma A AD - Pediatrics and Child health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania. FAU - Manji, Hussein K AU - Manji HK AD - Department of Emergency Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania. AD - Accident and Emergency Department, Aga Khan Health Services, Dar es Salaam, Tanzania. FAU - Sudfeld, Christopher R AU - Sudfeld CR AD - Departments of Nutrition and Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. FAU - Westbrook, Adrianna L AU - Westbrook AL AD - Pediatrics Biostatistics Core, Department of Pediatrics, Emory University, Atlanta, Georgia, USA. FAU - Niescierenko, Michelle AU - Niescierenko M AD - Division of Emergency Medicine, Boston Children's Hospital, Boston, Massachusetts, USA. AD - Department of Pediatrics and Emergency Medicine, Harvard Medical School, Boston, Massachusetts, USA. FAU - Morris, Claudia R AU - Morris CR AD - Division of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, USA. AD - Children's Healthcare of Atlanta, Atlanta, Georgia, USA. FAU - Florin, Todd A AU - Florin TA AD - Division of Emergency Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA. FAU - Whitney, Cynthia G AU - Whitney CG AD - Global Health Institute, Emory University, Atlanta, Georgia, USA. FAU - Manji, Karim P AU - Manji KP AD - Department of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania. FAU - Duggan, Christopher P AU - Duggan CP AD - Departments of Nutrition and Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. AD - Center for Nutrition, Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Kamaleswaran, Rishikesan AU - Kamaleswaran R AD - Division of Translational Biomedical Informatics, Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA. LA - eng GR - P30 DK040561/DK/NIDDK NIH HHS/United States GR - K24 DK104676/DK/NIDDK NIH HHS/United States GR - UL1 TR002378/TR/NCATS NIH HHS/United States GR - K24 AT009893/AT/NCCIH NIH HHS/United States GR - K23 HL173694/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Observational Study DEP - 20250619 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Tanzania/epidemiology MH - *Machine Learning MH - Infant, Newborn MH - Liberia/epidemiology MH - Infant MH - Female MH - Male MH - Risk Assessment/methods MH - *Patient Discharge/statistics & numerical data MH - Child, Preschool MH - Prospective Studies MH - *Infant Mortality PMC - PMC12182169 OTO - NOTNLM OT - Infant OT - Machine Learning OT - Mortality OT - Neonatology COIS- Competing interests: None declared. EDAT- 2025/06/21 00:32 MHDA- 2025/06/24 13:13 PMCR- 2025/06/19 CRDT- 2025/06/20 20:42 PHST- 2025/04/03 00:00 [received] PHST- 2025/06/05 00:00 [accepted] PHST- 2025/06/24 13:13 [medline] PHST- 2025/06/21 00:32 [pubmed] PHST- 2025/06/20 20:42 [entrez] PHST- 2025/06/19 00:00 [pmc-release] AID - 10.1136/bmjpo-2025-003547 [pii] AID - bmjpo-2025-003547 [pii] AID - 10.1136/bmjpo-2025-003547 [doi] PST - epublish SO - BMJ Paediatr Open. 2025 Jun 19;9(1):e003547. doi: 10.1136/bmjpo-2025-003547. PMID- 40540533 OWN - NLM STAT- MEDLINE DCOM- 20250701 LR - 20250703 IS - 1549-1676 (Electronic) IS - 1549-1277 (Print) IS - 1549-1277 (Linking) VI - 22 IP - 6 DP - 2025 Jun TI - The Fetal Region-specific Optimized Growth Standard (FROGS)-A fetal and birthweight centile calculator validated in a national population. PG - e1004634 LID - 10.1371/journal.pmed.1004634 [doi] LID - e1004634 AB - BACKGROUND: There is no universally agreed upon obstetric growth standard for use during pregnancy. We aimed to design a simple novel growth standard, which incorporates key beneficial features identified in prior research. METHODS AND FINDINGS: We developed the Fetal Region-specific Optimized Growth Standard (FROGS), then validated it following International Federation of Gynaecology and Obstetrics (FIGO) guidelines. FROGS follows the shape of the fetal (ultrasound-based) Hadlock curve. It is region-specific; allowing adjustment for the mean birthweight and standard deviation of babies born at term in the local population where it will be applied. It provides an exact centile for each gestational day (rather than rounding off by weeks) and is optionally adjustable for fetal sex. Further, FROGS provides an 'estimate range' for the estimated fetal weight centile, assuming a 10% ultrasound measurement error. Following development, we validated FROGS in a retrospective cohort study by comparing its ability to identify small babies with an increased risk of adverse perinatal outcomes to four charts in current use: (1) population birthweight chart (Australian Institute of Health and Welfare, AIHW chart); (2) Hadlock's 1991 fetal chart; (3) Mikolajczyk's global fetal and birthweight centile chart; and (4) INTERGROWTH-21st fetal growth standards. To do this, we identified infants classified as small for gestational age (<10th centile) by each chart. We then identified non-overlapping <10th centile populations, i.e., infants classified as small by one chart, but not another. We compared rates of stillbirth and adverse perinatal outcomes between the non-overlapping populations. All charts except INTERGROWTH classified similar proportions of infants as <10th centile (10.4% FROGS, 9.3% AIHW, 11.1% Hadlock, 10.9% global, 4.4% INTERGROWTH). Of the three charts that classified similar proportions as <10th centile, infants classified by FROGS were at the highest risk of adverse perinatal outcomes. The infants classified as <10th centile by only FROGS had significantly increased relative risk (RR) of stillbirth, compared to the infants classified as <10th centile by only AIHW (RR 13.1, 95% CI 6.5-26.5), only Hadlock (RR 2.1, 95% CI 1.28-3.56) or only the global chart (RR 1.54, 95% CI 1.00-2.37). The FROGS chart outperformed these three charts in identifying infants at risk of other adverse perinatal outcomes associated with being small for gestational age, such as neonatal intensive care admission, Apgar scores <7 at 5 min, and operative (instrumental) vaginal birth for suspected fetal compromise. The cohort of infants classified as small for gestational age by INTERGROWTH was, in size and risk, closer to the cohort classified as <3rd centile by FROGS (3.4% of infants <3rd). This study is limited in that it retrospectively assesses birthweight, which may have different implications to a prospective evaluation of estimated fetal weight. CONCLUSIONS: Compared to currently used charts, the Fetal Region-specific Optimized Growth Standard outperforms existing charts that classify a similar proportion of infants as small for gestational age in identifying small infants at increased risk of stillbirth and other serious perinatal outcomes. The FROGS centile algorithm is simple and transparent. It has the potential to be adapted to other local populations, or applied to clinical and research settings globally. CI - Copyright: (c) 2025 Pritchard et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Pritchard, Natasha L AU - Pritchard NL AUID- ORCID: 0000-0002-7388-2193 AD - Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, Victoria, Australia. AD - Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia. FAU - Tong, Stephen AU - Tong S AUID- ORCID: 0000-0002-2319-0586 AD - Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, Victoria, Australia. AD - Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia. FAU - MacDonald, Teresa AU - MacDonald T AUID- ORCID: 0000-0001-9099-7745 AD - Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, Victoria, Australia. AD - Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia. FAU - McCarthy, Elizabeth AU - McCarthy E AD - Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, Victoria, Australia. AD - Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia. FAU - Hui, Lisa AU - Hui L AD - Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, Victoria, Australia. AD - Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia. AD - Reproductive Epidemiology Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia. AD - The Northern Hospital, Epping, Victoria, Australia. FAU - Bethune, Michael AU - Bethune M AD - Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, Victoria, Australia. AD - Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia. FAU - Gordon, Hannah G AU - Gordon HG AUID- ORCID: 0000-0001-7510-0071 AD - Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, Victoria, Australia. AD - Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia. FAU - Hastie, Roxanne AU - Hastie R AD - Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, Victoria, Australia. AD - Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia. FAU - Keenan, Emerson AU - Keenan E AUID- ORCID: 0000-0003-1966-2293 AD - Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, Victoria, Australia. AD - Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia. FAU - Permezel, Michael AU - Permezel M AD - Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, Victoria, Australia. AD - Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia. FAU - Walker, Susan P AU - Walker SP AD - Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, Victoria, Australia. AD - Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia. FAU - Lindquist, Anthea C AU - Lindquist AC AUID- ORCID: 0000-0002-8662-5188 AD - Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, Victoria, Australia. AD - Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia. LA - eng PT - Journal Article PT - Validation Study DEP - 20250620 PL - United States TA - PLoS Med JT - PLoS medicine JID - 101231360 SB - IM MH - Humans MH - Female MH - *Birth Weight MH - *Fetal Development MH - Pregnancy MH - *Ultrasonography, Prenatal MH - Infant, Newborn MH - Male MH - Retrospective Studies MH - Gestational Age MH - *Growth Charts MH - Fetal Weight MH - Reference Values MH - Australia PMC - PMC12212869 COIS- I have read the journal's policy and the authors of this manuscript have the following competing interests: NP is a recipient of a Norman Beischer Innovation Grant for this project. RH is a paid statistical consultant on PLOS Medicine's statistical board. EDAT- 2025/06/20 18:26 MHDA- 2025/07/01 21:17 PMCR- 2025/06/20 CRDT- 2025/06/20 13:44 PHST- 2024/09/07 00:00 [received] PHST- 2025/05/09 00:00 [accepted] PHST- 2025/07/01 00:00 [revised] PHST- 2025/07/01 21:17 [medline] PHST- 2025/06/20 18:26 [pubmed] PHST- 2025/06/20 13:44 [entrez] PHST- 2025/06/20 00:00 [pmc-release] AID - PMEDICINE-D-24-02989 [pii] AID - 10.1371/journal.pmed.1004634 [doi] PST - epublish SO - PLoS Med. 2025 Jun 20;22(6):e1004634. doi: 10.1371/journal.pmed.1004634. eCollection 2025 Jun. PMID- 40539378 OWN - NLM STAT- MEDLINE DCOM- 20251112 LR - 20251112 IS - 1728-0591 (Electronic) IS - 1728-0583 (Linking) VI - 36 IP - 3 DP - 2025 Dec TI - Treatment outcomes for avoidant/restrictive food intake disorder and anorexia nervosa among children and adolescents in higher levels of care. PG - 480-491 LID - 10.2989/17280583.2025.2504579 [doi] AB - Background: There is large variability in the way that outcomes are measured for avoidant/restrictive food intake disorder (ARFID), with many studies focusing solely on weight gain or using measures that are not designed or validated to assess ARFID symptoms, such as the widely used Eating Disorders Examination-Questionnaire (EDE-Q).Objective: The current study compared treatment outcomes for children/adolescents with ARFID to children/adolescents with anorexia nervosa-restricting subtype (AN-R) on weight variables (% of expected body weight (%EBW)), ARFID symptoms as measured using the Eating Disorders in Youth-Questionnaire (EDY-Q), and eating disorder (ED) symptoms (as measured using the EDE-Q). Scores for both groups of patients on each measure were examined to preliminarily determine the appropriateness of each measure for each diagnosis.Method: Participants were 220 children/adolescents aged 9 to 17 receiving treatment at a large multisite treatment facility between November 2020 and June 2023. Self-report questionnaires were completed at intake and discharge, and weight was recorded throughout treatment.Results: EDY-Q, EDE-Q, and %EBW scores changed significantly (p < 0.001) from admission to discharge for both groups of patients. Effect sizes for changes in EDY-Q were similarly large for patients with AN-R (d = 0.91) and ARFID (d = 0.83). Effect sizes for changes in EDE-Q were large for patients with AN-R (d = 0.79) and small-to-medium for patients with ARFID (d = 0.47).Conclusions: Results suggest that the EDY-Q may be assessing symptoms present in both patients with ARFID and patients with AN-R. The study's findings suggest that the EDE-Q is not an appropriate measure for assessing outcomes among patients with ARFID. FAU - Rienecke, Renee D AU - Rienecke RD AUID- ORCID: 0000-0003-0423-7403 AD - Eating Recovery Center and Pathlight Mood & Anxiety Centers, Denver, United States of America. AD - Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, United States of America. FAU - Manwaring, Jamie AU - Manwaring J AD - Eating Recovery Center and Pathlight Mood & Anxiety Centers, Denver, United States of America. AD - ACUTE at Denver Health, Denver, United States of America. AD - Department of Medicine, University of Colorado, Denver, United States of America. FAU - Duffy, Alan AU - Duffy A AD - Eating Recovery Center and Pathlight Mood & Anxiety Centers, Denver, United States of America. FAU - Mehler, Philip S AU - Mehler PS AD - Eating Recovery Center and Pathlight Mood & Anxiety Centers, Denver, United States of America. AD - Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, United States of America. AD - ACUTE at Denver Health, Denver, United States of America. FAU - Blalock, Dan V AU - Blalock DV AD - Center of Innovation to Accelerate Discovery and Practice Transformation, Durham Veterans Affairs Medical Center, Durham, United States of America. AD - Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, United States of America. LA - eng PT - Journal Article DEP - 20250620 PL - South Africa TA - J Child Adolesc Ment Health JT - Journal of child and adolescent mental health JID - 101242019 SB - IM MH - Humans MH - Adolescent MH - Child MH - *Anorexia Nervosa/therapy/diagnosis MH - Female MH - Male MH - *Avoidant Restrictive Food Intake Disorder/therapy/diagnosis MH - Treatment Outcome MH - *Outcome Assessment, Health Care OTO - NOTNLM OT - anorexia nervosa OT - assessment OT - avoidant restrictive food intake disorder OT - eating disorders EDAT- 2025/06/20 12:26 MHDA- 2025/11/12 23:30 CRDT- 2025/06/20 06:03 PHST- 2025/11/12 23:30 [medline] PHST- 2025/06/20 12:26 [pubmed] PHST- 2025/06/20 06:03 [entrez] AID - 10.2989/17280583.2025.2504579 [doi] PST - ppublish SO - J Child Adolesc Ment Health. 2025 Dec;36(3):480-491. doi: 10.2989/17280583.2025.2504579. Epub 2025 Jun 20. PMID- 40539116 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250624 IS - 2055-2238 (Electronic) IS - 2055-2238 (Linking) VI - 11 IP - 3 DP - 2025 Jun TI - Confronting Pediatric Weight-Based Cybervictimization: Time for Action. PG - e70073 LID - 10.1002/osp4.70073 [doi] LID - e70073 AB - Weight-based victimization represents a critical challenge for youth, particularly those with obesity, and has been linked to a range of negative psychological, academic, and behavioral outcomes. While research has extensively examined in-person victimization, the rise of digital platforms has given way to weight-based cybervictimization, which remains understudied. This paper highlights the urgent need for research, prevention, and intervention strategies focused on weight-based cybervictimization, emphasizing its harmful effects and its overlap with traditional forms of victimization. It identifies gaps in the existing literature, particularly regarding the inconsistent use of assessment tools and terminology in research on weight-based victimization, and proposes the necessity for culturally relevant and validated measurement tools that accurately capture youth experiences. Finally, it aims to inform best practices for healthcare providers, educators, and parents by promoting strategies that effectively address and mitigate the impact of weight-based victimization among youth. CI - (c) 2025 The Author(s). Obesity Science & Practice published by World Obesity and The Obesity Society and John Wiley & Sons Ltd. FAU - Zumaglini, Silvia AU - Zumaglini S AD - Department of Counseling School, and Educational Psychology Graduate School of Education University at Buffalo Buffalo New York USA. FAU - Fredrick, Stephanie AU - Fredrick S AD - Department of Counseling School, and Educational Psychology Graduate School of Education University at Buffalo Buffalo New York USA. FAU - Thompson, J Kevin AU - Thompson JK AD - Department of Psychology University of South Florida Tampa Florida USA. FAU - Faith, Myles S AU - Faith MS AUID- ORCID: 0000-0002-8504-7945 AD - Department of Counseling School, and Educational Psychology Graduate School of Education University at Buffalo Buffalo New York USA. AD - Center for Ingestive Behavior Research University at Buffalo Buffalo New York USA. LA - eng PT - Journal Article DEP - 20250619 PL - United States TA - Obes Sci Pract JT - Obesity science & practice JID - 101675151 PMC - PMC12178210 OTO - NOTNLM OT - cybervictimization OT - obesity OT - schools OT - weight-based victimization COIS- The authors declare no conflicts of interest. EDAT- 2025/06/20 11:31 MHDA- 2025/06/20 11:32 PMCR- 2025/06/19 CRDT- 2025/06/20 04:35 PHST- 2025/02/18 00:00 [received] PHST- 2025/04/11 00:00 [revised] PHST- 2025/04/18 00:00 [accepted] PHST- 2025/06/20 11:32 [medline] PHST- 2025/06/20 11:31 [pubmed] PHST- 2025/06/20 04:35 [entrez] PHST- 2025/06/19 00:00 [pmc-release] AID - OSP470073 [pii] AID - 10.1002/osp4.70073 [doi] PST - epublish SO - Obes Sci Pract. 2025 Jun 19;11(3):e70073. doi: 10.1002/osp4.70073. eCollection 2025 Jun. PMID- 40537861 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250930 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 13 IP - 1 DP - 2025 Jun 19 TI - Validation of the parent version of the eating disorder examination-questionnaire adapted for children in parent-child dyads with children with and without loss of control eating. PG - 118 LID - 10.1186/s40337-025-01293-z [doi] LID - 118 AB - BACKGROUND: This study validated a parent-report version of the Eating Disorder Examination-Questionnaire adapted for Children (ChEDE-Q), referred to as the ChEDE-QP, within a population-based sample of parent-child dyads, including both children with and without loss of control (LOC) eating. METHOD: The ChEDE-QP was completed by 115 parent-child dyads. Item characteristics, reliability, factor structure, discriminant, convergent, and criterion validity were evaluated. The child version of the Eating Disorder Examination (ChEDE) interview and the ChEDE-Q were used for validation. RESULTS: Missing item responses occurred in 0-4% of items. Corrected item-subscale correlations were mostly sufficient. Internal consistency ranged from acceptable to excellent. Medium-sized correlations between ChEDE-QP, ChEDE-Q and ChEDE global and subscale scores indicated satisfying convergent validity. Nonsignificant differences between children with and without LOC indicated low discriminant validity. Regarding the presence of LOC eating, parental and child reports were poorly associated. DISCUSSION: The ChEDE-QP was found to be a reliable questionnaire for assessing children's eating disorder psychopathology, indicating that parents are helpful for gaining a general understanding of eating disorder psychopathology. However, the agreement on the presence of LOC eating between parents and children was low indicating that the ChEDE-QP should not be used for assessing LOC eating episodes in the absence of child report. CI - (c) 2025. The Author(s). FAU - Lange, Caroline AU - Lange C AUID- ORCID: 0009-0001-1724-8008 AD - Department of Psychosomatic Medicine and Psychotherapy, Behavioral Medicine Research Unit, Integrated Research and Treatment Center AdiposityDiseases, Leipzig University Medical Center, Leipzig, Germany. FAU - Schmidt, Ricarda AU - Schmidt R AUID- ORCID: 0000-0001-7794-2897 AD - Department of Psychosomatic Medicine and Psychotherapy, Behavioral Medicine Research Unit, Integrated Research and Treatment Center AdiposityDiseases, Leipzig University Medical Center, Leipzig, Germany. AD - German Center for Child and Adolescent Health (DZKJ), Partner site Leipzig/Dresden, Leipzig, Germany. FAU - Hilbert, Anja AU - Hilbert A AUID- ORCID: 0000-0003-2775-1296 AD - Department of Psychosomatic Medicine and Psychotherapy, Behavioral Medicine Research Unit, Integrated Research and Treatment Center AdiposityDiseases, Leipzig University Medical Center, Leipzig, Germany. anja.hilbert@medizin.uni-leipzig.de. AD - German Center for Child and Adolescent Health (DZKJ), Partner site Leipzig/Dresden, Leipzig, Germany. anja.hilbert@medizin.uni-leipzig.de. LA - eng GR - HI 1111/1-1/German Research Foundation/ PT - Journal Article DEP - 20250619 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 EIN - J Eat Disord. 2025 Sep 29;13(1):218. doi: 10.1186/s40337-025-01417-5. PMID: 41023752 PMC - PMC12180226 OAB - This study tested a new parent-report questionnaire, the Parent Version of the Eating Disorder Examination-Questionnaire adapted for Children (ChEDE-QP). The aim was to help understand children's eating behaviors. We asked 115 parents to complete the questionnaire, including parents whose children reported loss of control eating and healthy controls. Overall, the ChEDE-QP worked well: it reliably showed whether children had certain eating problems, and it had a high agreement with children's own responses to questions about eating. However, the ChEDE-QP did not always pick up when a child experienced loss of control eating. This means that while the ChEDE-QP can be useful for getting an overall picture of a child's eating behavior, parents alone may not always recognize moments when their child loses control of their eating. For that, the child's own point of view remains essential. OABL- eng OTO - NOTNLM OT - Assessment OT - Binge eating OT - ChEDE-Q OT - Eating disorder OT - Loss of control eating OT - Parent OT - Psychometric properties OT - Validation COIS- Declarations. Ethics approval and consent to participate: This study was approved by the ethics committee of the German Psychological Society. Written informed consent was provided by participating parents and assent was given by children prior to study participation. Consent for publication: Not applicable. Competing interests: Dr. Hilbert reports receiving research grants from the German Federal Ministry of Education and Research, the German Research Foundation (DFG), the Innovation Fund, and the Roland Ernst Foundation for Health Care; royalties for books on the treatment of eating disorders and obesity from Hogrefe and Kohlhammer; honoraria for workshops and lectures on eating disorders and obesity (e.g., from Lilly); honoraria as editor of the International Journal of Eating Disorders and the journal Psychotherapeut; honoraria as a reviewer from Oxford University Press and the German Society for Nutrition; and honoraria as a consultant for Takeda. No other competing interests were declared. EDAT- 2025/06/20 00:25 MHDA- 2025/06/20 00:26 PMCR- 2025/06/19 CRDT- 2025/06/19 23:28 PHST- 2025/01/28 00:00 [received] PHST- 2025/05/17 00:00 [accepted] PHST- 2025/06/20 00:26 [medline] PHST- 2025/06/20 00:25 [pubmed] PHST- 2025/06/19 23:28 [entrez] PHST- 2025/06/19 00:00 [pmc-release] AID - 10.1186/s40337-025-01293-z [pii] AID - 1293 [pii] AID - 10.1186/s40337-025-01293-z [doi] PST - epublish SO - J Eat Disord. 2025 Jun 19;13(1):118. doi: 10.1186/s40337-025-01293-z. PMID- 40537784 OWN - NLM STAT- MEDLINE DCOM- 20250623 LR - 20250624 IS - 1476-511X (Electronic) IS - 1476-511X (Linking) VI - 24 IP - 1 DP - 2025 Jun 19 TI - Diagnostic performance of anthropometric measurements for identifying obesity in high-altitude pediatric populations: evidence from tibet via bioelectrical impedance analysis. PG - 216 LID - 10.1186/s12944-025-02623-5 [doi] LID - 216 AB - BACKGROUND: The diagnostic accuracy of anthropometric measurements for obesity screening in high-altitude pediatric populations remains understudied, particularly since existing measurements have been validated predominantly in lowland populations. This study evaluated the effectiveness of 19 anthropometric measurements for obesity screening among youth residing in the Tibetan Plateau region, aiming to identify the most reliable measurement approach for this distinct demographic. METHODS: This study included 1,650 Tibetan and Han Chinese students aged 8-18 years from six schools in Lhasa's Chengguan District (altitude 3,650 m). Anthropometric measurements comprised both basic anthropometric parameters and computed indices. The basic anthropometric parameters included height, weight, waist circumference, mid-upper arm circumference as well as skinfold thickness measured at three sites, such as abdominal skinfold thickness (AST). The computed indices consisted of Body Mass Index (BMI), the tri-ponderal mass index (TMI), the sum of skinfold thickness from two or three (SuST(3)) sites, the waist-to-height ratio, the mid-upper arm-to-height ratio, the conicity index (C-index), the relative fat mass, the body roundness index, two variants of a body shape index (ABSI(OR) and ABSI(CN)), and two percentage body fat values derived from two skinfold thickness equations (such as Y-PBF). Bioelectrical impedance analysis-derived percentage of body fat (PBF(BIA)) was used as the reference method to construct Receiver Operating Characteristic (ROC) curves for the 19 anthropometric measurements, and the Area Under the Curve (AUC) was calculated to evaluate the performance of each measurement in obesity screening. RESULTS: Statistical analysis revealed that TMI, SuST(3), AST, and BMI consistently demonstrated robust correlations with PBF(BIA) across all demographic subgroups (p < 0.001, r > 0.7) and exhibited strong diagnostic capabilities (AUC > 0.800). Among all anthropometric measurements, the TMI, SuST(3), AST, Y-PBF, and BMI had the highest subgroup mean rankings according to the AUC (top 5), and the ABSI(OR), C-index, and ABSI(CN) were the worst (bottom 3). DeLong's test confirmed these measurements as optimal measures in the majority of population subgroups (> 10 out of 19 subgroups), with the TMI showing the most comprehensive applicability (valid for the total sample and 17 subgroups). Notably, the TMI also demonstrated the highest stability in cutoff values (SD = 0.49, range = 1.89) and superior diagnostic performance (accuracy = 0.84, precision = 0.70, recall = 0.83, F score = 0.75). CONCLUSIONS: Our findings indicate that the TMI is the best anthropometric indices for screening for obesity in children and adolescents on the Tibetan Plateau, with a wide range of applicability to population subgroups and a stable optimal cutoff value. CI - (c) 2025. The Author(s). FAU - Nie, Ming-Jian AU - Nie MJ AD - School of Sport Science & Key Laboratoryof the, Ministry of Education of Exercise and Physical Fitness , Beijing Sport University, Beijing, 100061, China. FAU - Sun, Rui-Zhe AU - Sun RZ AD - Tibet Institute of Sport Science, Lhasa, 850007, China. AD - Key Laboratory of Plateau Sports and Health of XiZang Autonomous Region, Lhasa, 850007, China. FAU - Fan, Chao-Qun AU - Fan CQ AD - Institute of Sport Science, Beijing, 100061, China. FAU - Wang, Jing-Jing AU - Wang JJ AD - Institute of Sport Science, Beijing, 100061, China. FAU - Fei, Xi AU - Fei X AD - Beijing College of Sports, Beijing, 100075, China. FAU - Hu, Zi-Kang AU - Hu ZK AD - School of Sport Science & Key Laboratoryof the, Ministry of Education of Exercise and Physical Fitness , Beijing Sport University, Beijing, 100061, China. FAU - Li, Hong-Juan AU - Li HJ AD - School of Sport Science & Key Laboratoryof the, Ministry of Education of Exercise and Physical Fitness , Beijing Sport University, Beijing, 100061, China. janerobin@126.com. LA - eng GR - XZ202401ZY00014/Science and Technology Projects of XiZang Autonomous Region, China/ GR - XZ202401ZY00014/Science and Technology Projects of XiZang Autonomous Region, China/ GR - XZ202401ZY00014/Science and Technology Projects of XiZang Autonomous Region, China/ GR - XZ202401ZY00014/Science and Technology Projects of XiZang Autonomous Region, China/ GR - XZ202401ZY00014/Science and Technology Projects of XiZang Autonomous Region, China/ GR - XZ202401ZY00014/Science and Technology Projects of XiZang Autonomous Region, China/ GR - XZ202401ZY00014/Science and Technology Projects of XiZang Autonomous Region, China/ GR - 2015B121/Science and Education Department of the General Administration of Sport of China/ GR - 2015B121/Science and Education Department of the General Administration of Sport of China/ GR - 2015B121/Science and Education Department of the General Administration of Sport of China/ GR - 2015B121/Science and Education Department of the General Administration of Sport of China/ GR - 2015B121/Science and Education Department of the General Administration of Sport of China/ GR - 2015B121/Science and Education Department of the General Administration of Sport of China/ GR - 2015B121/Science and Education Department of the General Administration of Sport of China/ PT - Journal Article DEP - 20250619 PL - England TA - Lipids Health Dis JT - Lipids in health and disease JID - 101147696 SB - IM MH - Humans MH - Child MH - Tibet/epidemiology MH - *Altitude MH - Adolescent MH - Male MH - Female MH - *Electric Impedance MH - *Anthropometry/methods MH - Body Mass Index MH - Skinfold Thickness MH - Waist Circumference MH - *Obesity/diagnosis/epidemiology MH - ROC Curve MH - *Pediatric Obesity/diagnosis PMC - PMC12177966 OTO - NOTNLM OT - Adolescent OT - Anthropometry OT - Child OT - Obesity OT - Tibetan Plateau OT - Tri-ponderal mass index COIS- Declarations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/06/20 00:25 MHDA- 2025/06/24 11:08 PMCR- 2025/06/19 CRDT- 2025/06/19 23:25 PHST- 2025/01/08 00:00 [received] PHST- 2025/05/23 00:00 [accepted] PHST- 2025/06/24 11:08 [medline] PHST- 2025/06/20 00:25 [pubmed] PHST- 2025/06/19 23:25 [entrez] PHST- 2025/06/19 00:00 [pmc-release] AID - 10.1186/s12944-025-02623-5 [pii] AID - 2623 [pii] AID - 10.1186/s12944-025-02623-5 [doi] PST - epublish SO - Lipids Health Dis. 2025 Jun 19;24(1):216. doi: 10.1186/s12944-025-02623-5. PMID- 40537092 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250630 IS - 2561-6722 (Electronic) IS - 2561-6722 (Linking) VI - 8 DP - 2025 Jun 19 TI - An Online Family Literacy and Wellness Program for Latino Dual Language Learners: Pilot Randomized Waitlist Controlled Trial. PG - e60764 LID - 10.2196/60764 [doi] LID - e60764 AB - BACKGROUND: Early childhood interventions can simultaneously promote positive health and early language experiences, but implementation and health equity often receive insufficient attention during the development process. OBJECTIVE: We apply a health equity lens to refine and pilot-test a family literacy and wellness program designed for Latino dual language learners (DLLs) entering kindergarten and their caregivers. METHODS: In collaboration with a parent and community advisory board, we refined an 8-week family literacy and wellness program and conducted a pilot randomized controlled trial (RCT) with a waitlist control. The program, specifically designed by our interprofessional team for Latino DLLs, uses health topics (ie, nutrition, physical activity, sleep, and social-emotional development) to (1) introduce foundational language and literacy skills to children; (2) empower families to engage in health and home literacy activities using a strengths-based approach; and (3) encourage maintenance of families' home language. We assessed reach by collecting sociodemographic information; attendance and acceptability using a parent survey; and preliminary effects on home literacy activities through a validated parent-report instrument (StimQ2 quantity, quality, content, and concepts subdomains) and on child literacy skills using investigator-developed assessments. We analyzed quantitative data using descriptive statistics and regression analyses. RESULTS: Parents and community advisors informed the program content. A total of 32 parent-child dyads were enrolled in the pilot RCT. All parents identified as Latino, and half had not completed high school, indicating that we reached the intended audience. Parents rated the program as highly acceptable, and 23 (72%) participants attended at least half of the sessions. After participation, group 1 had higher StimQ2 quality scores (effect size 0.99, P=.02) and higher quantity scores (effect size 1.01, P=.04) compared with group 2. CONCLUSIONS: Similar interprofessional collaborations may be a promising strategy to promote equity in early language experiences for Latino DLLs and their families. CI - (c) Kevin D Guerrero, Lucia Lakata, Daniel Lima, Caroline Mendoza, Nila Uthirasamy, Lesley M Morrow, Silvia Perez-Cortes, Maria Pellerano, Alicja Bator, Pamela Ohman Strickland, Benjamin F Crabtree, Manuel E Jimenez. Originally published in JMIR Pediatrics and Parenting (https://pediatrics.jmir.org). FAU - Guerrero, Kevin D AU - Guerrero KD AUID- ORCID: 0000-0002-7749-5211 AD - Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States. FAU - Lakata, Lucia AU - Lakata L AUID- ORCID: 0009-0003-0879-0190 AD - Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States. FAU - Lima, Daniel AU - Lima D AUID- ORCID: 0009-0003-4298-1564 AD - The Boggs Center on Disability and Human Development, Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, Liberty Plaza - 335 George Street, 3rd Floor, New Brunswick, NJ, 08901, United States, 1 732-235-9300. FAU - Mendoza, Caroline AU - Mendoza C AUID- ORCID: 0009-0005-1967-2426 AD - The Boggs Center on Disability and Human Development, Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, Liberty Plaza - 335 George Street, 3rd Floor, New Brunswick, NJ, 08901, United States, 1 732-235-9300. FAU - Uthirasamy, Nila AU - Uthirasamy N AUID- ORCID: 0000-0002-3300-3924 AD - The Boggs Center on Disability and Human Development, Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, Liberty Plaza - 335 George Street, 3rd Floor, New Brunswick, NJ, 08901, United States, 1 732-235-9300. FAU - Morrow, Lesley M AU - Morrow LM AUID- ORCID: 0000-0002-1892-2260 AD - Graduate School of Education, Rutgers University, New Brunswick, NJ, United States. FAU - Perez-Cortes, Silvia AU - Perez-Cortes S AUID- ORCID: 0000-0002-3652-0118 AD - Camden College of Arts and Sciences, Rutgers University, Camden, NJ, United States. FAU - Pellerano, Maria AU - Pellerano M AUID- ORCID: 0000-0002-8808-7029 AD - Department of Family Medicine and Community Health, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States. FAU - Bator, Alicja AU - Bator A AUID- ORCID: 0000-0001-7773-2953 AD - Department of Family Medicine and Community Health, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States. FAU - Ohman Strickland, Pamela AU - Ohman Strickland P AUID- ORCID: 0000-0001-7877-7125 AD - Rutgers School of Public Health, Piscataway, NJ, United States. FAU - Crabtree, Benjamin F AU - Crabtree BF AUID- ORCID: 0000-0003-2292-6835 AD - Department of Family Medicine and Community Health, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States. FAU - Jimenez, Manuel E AU - Jimenez ME AUID- ORCID: 0000-0003-0497-1480 AD - The Boggs Center on Disability and Human Development, Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, Liberty Plaza - 335 George Street, 3rd Floor, New Brunswick, NJ, 08901, United States, 1 732-235-9300. LA - eng GR - R18 HS028574/HS/AHRQ HHS/United States PT - Journal Article DEP - 20250619 PL - Canada TA - JMIR Pediatr Parent JT - JMIR pediatrics and parenting JID - 101727244 PMC - PMC12202239 OTO - NOTNLM OT - ESL OT - English as a second language OT - Hispanic OT - Latinos OT - Spanish OT - child development OT - children OT - controlled trials OT - development OT - dual language learner OT - family OT - health equity OT - language OT - literacy OT - pediatrics OT - randomized OT - wellness COIS- Conflicts of Interest: None declared. EDAT- 2025/06/19 22:03 MHDA- 2025/06/19 22:04 PMCR- 2025/06/19 CRDT- 2025/06/19 17:02 PHST- 2024/05/20 00:00 [received] PHST- 2024/12/19 00:00 [revised] PHST- 2025/01/16 00:00 [accepted] PHST- 2025/06/19 22:04 [medline] PHST- 2025/06/19 22:03 [pubmed] PHST- 2025/06/19 17:02 [entrez] PHST- 2025/06/19 00:00 [pmc-release] AID - v8i1e60764 [pii] AID - 60764 [pii] AID - 10.2196/60764 [doi] PST - epublish SO - JMIR Pediatr Parent. 2025 Jun 19;8:e60764. doi: 10.2196/60764. PMID- 40537051 OWN - NLM STAT- MEDLINE DCOM- 20250619 LR - 20250622 IS - 2047-2986 (Electronic) IS - 2047-2978 (Print) IS - 2047-2978 (Linking) VI - 15 DP - 2025 Jun 20 TI - Evaluation of the reliability and validity of a Caregivers' Complementary Feeding Practice Scale (CCFPS) for children aged 6-23 months in urban areas of China. PG - 04170 LID - 10.7189/jogh.15.04170 [doi] LID - 04170 AB - BACKGROUND: Caregivers' feeding practices significantly influence children's eating behaviours. We previously developed a Caregivers' Complementary Feeding Practice Scale (CCFPS) for children aged 6-23 months in China. We aimed to comprehensively assess the CCFPS's reliability and validity, thus establishing a reliable and robust tool for evaluating caregivers' feeding practices. METHODS: Through convenience sampling, we recruited 928 caregivers from community health centres. We assessed the scale's reliability with Cronbach's alpha and split-half analysis. Additionally, we used the content validity index (CVI) for content validity. Lastly, we examined structural validity with exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). RESULTS: The scale's Cronbach's alpha coefficient was 0.783, and its split-half reliability coefficient reached 0.750. The CVI was 0.910. EFA supported the scale's six-factor structure, which explained 51.43% of the total variance. The CFA results demonstrated that the fit indices of the model were higher than the acceptable level, indicating the scale provides a good level of validity. CONCLUSIONS: The CCFPS is a reliable and valid tool for assessing caregivers' feeding practices with infants and young children aged 6 to 23 months in urban China, suitable for research and clinical applications. CI - Copyright (c) 2025 by the Journal of Global Health. All rights reserved. FAU - Wu, Qiong AU - Wu Q AD - Department of Integrated Early Childhood Development, Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing, China. FAU - Meng, Na AU - Meng N AD - Department of Integrated Early Childhood Development, Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing, China. FAU - Xie, Lihui AU - Xie L AD - Department of Health Quarantine, Beijing Customs District P.R.China, Beijing, China. FAU - Li, Lin AU - Li L AD - Beijing KidsHome Children Development Centre, Beijing, China. FAU - Huang, Yiwen AU - Huang Y AD - Child Healthcare Center, Capital Center for Children's Health, Capital Medical University, Beijing, China. FAU - Zhang, Yanfeng AU - Zhang Y AD - Department of Integrated Early Childhood Development, Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20250620 PL - Scotland TA - J Glob Health JT - Journal of global health JID - 101578780 SB - IM MH - Humans MH - Infant MH - China MH - Reproducibility of Results MH - *Caregivers/statistics & numerical data/psychology MH - Female MH - Male MH - *Infant Nutritional Physiological Phenomena MH - Surveys and Questionnaires/standards MH - Urban Population MH - *Feeding Behavior MH - Adult MH - Factor Analysis, Statistical MH - Psychometrics PMC - PMC12178594 COIS- Disclosure of interest: The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests. EDAT- 2025/06/19 22:03 MHDA- 2025/06/19 22:04 PMCR- 2025/06/20 CRDT- 2025/06/19 15:33 PHST- 2025/06/19 22:04 [medline] PHST- 2025/06/19 22:03 [pubmed] PHST- 2025/06/19 15:33 [entrez] PHST- 2025/06/20 00:00 [pmc-release] AID - jogh-15-04170 [pii] AID - 10.7189/jogh.15.04170 [doi] PST - epublish SO - J Glob Health. 2025 Jun 20;15:04170. doi: 10.7189/jogh.15.04170. PMID- 40536026 OWN - NLM STAT- MEDLINE DCOM- 20250619 LR - 20260910 IS - 1365-2060 (Electronic) IS - 0785-3890 (Print) IS - 0785-3890 (Linking) VI - 57 IP - 1 DP - 2025 Dec TI - Distinct patterns of health risk behaviours in adolescents with thalassaemia. PG - 2521441 LID - 10.1080/07853890.2025.2521441 [doi] LID - 2521441 AB - BACKGROUND: Thalassaemia is a significant public health concern in Southeast Asia, yet little is known about health risk behaviours in adolescents with this condition. This study aimed to compare health risk behaviours between adolescents with thalassaemia and healthy controls, and to identify associated clinical and sociodemographic factors. METHODS: This cross-sectional study included 60 adolescents with thalassaemia (aged 10-18 years) and 60 age- and sex-matched healthy controls in Thailand. Health risk behaviours were assessed using the validated Thai Youth Risk Behaviour Survey. Clinical data were extracted from medical records. Multivariable logistic regression was used to identify factors associated with risk behaviours. RESULTS: Adolescents with thalassaemia reported higher rates of non-seatbelt use (25.0% vs. 1.7%, p < 0.001) and mental health problems (13.3% vs. 0.8%, p = 0.027) compared to controls. However, they exhibited lower rates of inadequate exercise (70.0% vs. 86.7%, p = 0.045) and excessive screen time (66.7% vs. 96.7%, p < 0.001). In the thalassaemia group, older age (aOR = 2.78, 95% CI: 1.09-7.09), female gender (aOR = 39.73, 95% CI: 0.89-1770.49) and lower pre-transfusion haemoglobin levels (aOR = 0.09, 95% CI: 0.01-0.64) were associated with increased odds of mental health problems. Higher pre-transfusion haemoglobin levels were associated with lower odds of violent behaviour (aOR = 0.44, 95% CI: 0.21-0.92). CONCLUSIONS: Adolescents with thalassaemia exhibit distinct patterns of health risk behaviours, influenced by age, gender and disease severity. These findings underscore the need for integrated physical and psychosocial care, highlighting the importance of tailored health education and interventions for this vulnerable group. FAU - Kaewkong, Pattaporn AU - Kaewkong P AD - Department of Pediatrics, Chiang Mai University, Chiang Mai, Thailand. FAU - Boonchooduang, Nonglak AU - Boonchooduang N AUID- ORCID: 0000-0001-9163-2916 AD - Department of Pediatrics, Chiang Mai University, Chiang Mai, Thailand. FAU - Likhitweerawong, Narueporn AU - Likhitweerawong N AUID- ORCID: 0000-0002-1175-0021 AD - Department of Pediatrics, Chiang Mai University, Chiang Mai, Thailand. FAU - Charoenkwan, Pimlak AU - Charoenkwan P AUID- ORCID: 0000-0002-9123-9177 AD - Department of Pediatrics, Chiang Mai University, Chiang Mai, Thailand. AD - Thalassemia and Hematology Center, Chiang Mai University, Chiang Mai, Thailand. FAU - Louthrenoo, Orawan AU - Louthrenoo O AUID- ORCID: 0000-0002-7728-1117 AD - Department of Pediatrics, Chiang Mai University, Chiang Mai, Thailand. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250619 PL - England TA - Ann Med JT - Annals of medicine JID - 8906388 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - Cross-Sectional Studies MH - *Thalassemia/psychology/epidemiology MH - Child MH - Thailand/epidemiology MH - *Health Risk Behaviors MH - Case-Control Studies MH - *Adolescent Behavior/psychology MH - Logistic Models MH - Risk-Taking PMC - PMC12180315 OTO - NOTNLM OT - Thalassaemia OT - adolescent health OT - chronic disease OT - mental health OT - risk-taking behaviour COIS- No potential conflict of interest was reported by the authors. EDAT- 2025/06/19 07:53 MHDA- 2025/06/19 12:25 PMCR- 2025/06/19 CRDT- 2025/06/19 05:53 PHST- 2025/06/19 12:25 [medline] PHST- 2025/06/19 07:53 [pubmed] PHST- 2025/06/19 05:53 [entrez] PHST- 2025/06/19 00:00 [pmc-release] AID - 2521441 [pii] AID - 10.1080/07853890.2025.2521441 [doi] PST - ppublish SO - Ann Med. 2025 Dec;57(1):2521441. doi: 10.1080/07853890.2025.2521441. Epub 2025 Jun 19. PMID- 40536023 OWN - NLM STAT- MEDLINE DCOM- 20251112 LR - 20260703 IS - 1600-9657 (Electronic) IS - 1600-4469 (Print) IS - 1600-4469 (Linking) VI - 41 IP - 6 DP - 2025 Dec TI - Psychomotor Development and Traumatic Dental Injuries in Preschool. PG - 634-640 LID - 10.1111/edt.13072 [doi] AB - BACKGROUND/AIM: Insufficient motor coordination can predispose children to falls and, consequently, the occurrence of traumatic dental injuries (TDIs). The present study investigated the association between psychomotor development and TDI in preschool children. MATERIALS AND METHODS: A cross-sectional study was conducted with 189 children aged three to six years in Diamantina, Brazil. Psychomotor development was assessed using the Test of Gross Motor Development-Second Edition (motor assessment) and a validated preschool version of the Mini-Mental State Examination (cognitive assessment). Parents/guardians answered a socioeconomic questionnaire. Anthropometric measures were determined using WHO growth curves to obtain the body mass index (BMI). Intraoral examinations were performed by a single examiner trained and calibrated for diagnosing TDI based on the criteria proposed by Andreasen, with radiographic evaluations conducted when necessary. Lip coverage, anterior open bite, arch shape, and overjet were also recorded. Descriptive statistics, the chi-square test, and Poisson regression (bivariate and multivariate) analyses were performed (95% CI, p < 0.05). RESULTS: The prevalence of TDI was 50.3%. Delayed motor development (PR = 1.66; 95% CI: 1.25-2.22) and obesity (PR = 1.64; 95% CI: 1.10-2.45) were significantly associated with TDI in the adjusted model. CONCLUSION: Delayed motor development and obesity were associated with TDI in preschool children. CI - (c) 2025 The Author(s). Dental Traumatology published by John Wiley & Sons Ltd. FAU - Primo-Miranda, Ednele Fabyene AU - Primo-Miranda EF AUID- ORCID: 0000-0002-1932-1213 AD - Departamento de Odontologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Minas Gerais, Brazil. FAU - Ramos-Jorge, Maria Leticia AU - Ramos-Jorge ML AD - Departamento de Odontologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Minas Gerais, Brazil. FAU - de Souza Morais, Rosane Luzia AU - de Souza Morais RL AD - Departamento de Fisioterapia, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Minas Gerais, Brazil. FAU - Silva, Paloma Christina Aguiar AU - Silva PCA AD - Departamento de Fisioterapia, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Minas Gerais, Brazil. FAU - Souto-Souza, Debora AU - Souto-Souza D AD - Departamento de Odontologia, Centro Universitario Do Triangulo (UNITRI), Uberlandia, Minas Gerais, Brazil. FAU - Marques, Leandro Silva AU - Marques LS AD - Departamento de Odontologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Minas Gerais, Brazil. LA - eng GR - Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ GR - Fundacao de Amparo a Pesquisa do Estado de Minas Gerais/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250619 PL - Denmark TA - Dent Traumatol JT - Dental traumatology : official publication of International Association for Dental Traumatology JID - 101091305 SB - IM MH - Humans MH - Child, Preschool MH - Cross-Sectional Studies MH - Male MH - Female MH - Brazil/epidemiology MH - *Tooth Injuries/epidemiology MH - Child MH - *Child Development MH - Prevalence PMC - PMC12605699 OTO - NOTNLM OT - malocclusion OT - preschool children OT - psychomotor development OT - traumatic dental injury COIS- The authors declare no conflicts of interest. EDAT- 2025/06/19 07:53 MHDA- 2025/11/13 06:11 PMCR- 2025/11/12 CRDT- 2025/06/19 05:53 PHST- 2025/04/25 00:00 [revised] PHST- 2024/10/28 00:00 [received] PHST- 2025/05/06 00:00 [accepted] PHST- 2025/11/13 06:11 [medline] PHST- 2025/06/19 07:53 [pubmed] PHST- 2025/06/19 05:53 [entrez] PHST- 2025/11/12 00:00 [pmc-release] AID - EDT13072 [pii] AID - 10.1111/edt.13072 [doi] PST - ppublish SO - Dent Traumatol. 2025 Dec;41(6):634-640. doi: 10.1111/edt.13072. Epub 2025 Jun 19. PMID- 40532141 OWN - NLM STAT- MEDLINE DCOM- 20250618 LR - 20260817 IS - 2369-2960 (Electronic) IS - 2369-2960 (Linking) VI - 11 DP - 2025 Jun 18 TI - Development of Machine Learning-Based Risk Prediction Models to Predict Rapid Weight Gain in Infants: Analysis of Seven Cohorts. PG - e69220 LID - 10.2196/69220 [doi] LID - e69220 AB - BACKGROUND: Rapid weight gain (RWG) during infancy, defined as an upward crossing of one centile line on a weight growth chart, is highly predictive of subsequent obesity risk. Identification of infant RWG could facilitate obesity risk assessment from infancy. OBJECTIVE: Leveraging machine learning (ML) algorithms, this study aimed to develop and validate risk prediction models to identify infant RWG by the age of 1 year. METHODS: Data from 7 Australian and New Zealand cohorts were pooled for risk model development and validation (n=5233). A total of 8 ML algorithms predicted infant RWG using routinely available prenatal and early postnatal factors, including maternal prepregnancy weight status, maternal smoking during pregnancy, gestational age, parity, infant sex, birth weight, any breastfeeding and timing of solids introduction at the age of 6 months. Pooled data were randomly split into a training dataset (70%) and a test dataset (30%) for model training and validation, respectively. Model consistency was evaluated using 5-fold cross-validation. Model predictive performance was evaluated by area under the receiver operating characteristic (ROC) curve (AUC), accuracy, precision, sensitivity, specificity, and Cohen kappa. RESULTS: The average prevalence of infant RWG was 27%. In the training dataset, all ML algorithms showed acceptable to excellent discrimination with AUCs ranging from 0.75 to 0.86. Accuracy, which indicates the overall correctness of the model, ranged from 0.69 to 0.78. Precision, which measures the model's ability to avoid false positives, ranged from 0.68 to 0.77. The spread of sensitivity, specificity, and Cohen kappa of all models was 0.68-0.80, 0.65-0.78, and 0.38-0.56, respectively. Of the 8 algorithms, the Gradient Boosting model showed the most favorable predictive accuracy. Validation of the Gradient Boosting model in the testing dataset exhibited excellent discrimination (AUC 0.3-0.6) and good ability to make accurate predictions, particularly true positive cases (with accuracy and sensitivity>0.75), but modest performance for precision (0.57-0.60) and Cohen kappa (0.47-0.52). CONCLUSIONS: This study developed the first set of ML-based risk prediction models to identify infants' risk of experiencing RWG by the age of 1 year with acceptable accuracy. The models could be feasibly integrated into routine child growth monitoring and may facilitate population-wide early obesity risk assessment in primary health care. CI - (c) Miaobing Zheng, Yuxin Zhang, Rachel A Laws, Peter Vuillermin, Jodie Dodd, Li Ming Wen, Louise A Baur, Rachael Taylor, Rebecca Byrne, Anne-Louise Ponsonby, Kylie D Hesketh. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org). FAU - Zheng, Miaobing AU - Zheng M AUID- ORCID: 0000-0002-4151-3502 AD - Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia. AD - School of Health Sciences, Faculty of Health & Medicine, UNSW Sydney, Wallace Wurth Building, Kensington, 2330, Australia, 61 0290659337. FAU - Zhang, Yuxin AU - Zhang Y AUID- ORCID: 0000-0002-7636-4084 AD - Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia. FAU - Laws, Rachel A AU - Laws RA AUID- ORCID: 0000-0003-4328-1116 AD - Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia. FAU - Vuillermin, Peter AU - Vuillermin P AUID- ORCID: 0000-0002-6580-0346 AD - Barwon Health, Geelong, Australia. FAU - Dodd, Jodie AU - Dodd J AUID- ORCID: 0000-0002-6363-4874 AD - Discipline of Obstetrics and Gynaecology, The Robinson Research Institute, The University of Adelaide, Adelaide, Australia. FAU - Wen, Li Ming AU - Wen LM AUID- ORCID: 0000-0003-1381-4022 AD - School of Public Health and Sydney Medical School, The University of Sydney, Sydney, Australia. FAU - Baur, Louise A AU - Baur LA AUID- ORCID: 0000-0002-4521-9482 AD - School of Public Health and Sydney Medical School, The University of Sydney, Sydney, Australia. FAU - Taylor, Rachael AU - Taylor R AUID- ORCID: 0000-0001-9516-2253 AD - Department of Medicine, University of Otago, Dunedin, New Zealand. FAU - Byrne, Rebecca AU - Byrne R AUID- ORCID: 0000-0002-0096-3320 AD - School of Exercise and Nutrition Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, Australia. FAU - Ponsonby, Anne-Louise AU - Ponsonby AL AUID- ORCID: 0000-0002-6581-3657 AD - The Florey Institute of Neuroscience and Mental Health, Murdoch Children's Research Institute, Royal Children's Hospital, The University of Melbourne, Parkville, Australia. FAU - Hesketh, Kylie D AU - Hesketh KD AUID- ORCID: 0000-0002-2702-7110 AD - Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia. LA - eng PT - Journal Article DEP - 20250618 PL - Canada TA - JMIR Public Health Surveill JT - JMIR public health and surveillance JID - 101669345 SB - IM MH - Humans MH - *Machine Learning MH - Infant MH - *Weight Gain/physiology MH - Female MH - Male MH - Risk Assessment/methods MH - New Zealand/epidemiology MH - Australia/epidemiology MH - Cohort Studies MH - Infant, Newborn PMC - PMC12192193 OTO - NOTNLM OT - childhood obesity OT - infants OT - machine learning OT - pooled analysis OT - rapid weight gain OT - risk prediction COIS- Conflicts of Interest: None declared. EDAT- 2025/06/18 18:26 MHDA- 2025/06/18 18:27 PMCR- 2025/06/18 CRDT- 2025/06/18 16:03 PHST- 2024/11/25 00:00 [received] PHST- 2025/03/18 00:00 [revised] PHST- 2025/03/25 00:00 [accepted] PHST- 2025/06/18 18:27 [medline] PHST- 2025/06/18 18:26 [pubmed] PHST- 2025/06/18 16:03 [entrez] PHST- 2025/06/18 00:00 [pmc-release] AID - v11i1e69220 [pii] AID - 69220 [pii] AID - 10.2196/69220 [doi] PST - epublish SO - JMIR Public Health Surveill. 2025 Jun 18;11:e69220. doi: 10.2196/69220. PMID- 40531519 OWN - NLM STAT- MEDLINE DCOM- 20250715 LR - 20251219 IS - 1538-3598 (Electronic) IS - 0098-7484 (Print) IS - 0098-7484 (Linking) VI - 334 IP - 3 DP - 2025 Jul 15 TI - Addictive Screen Use Trajectories and Suicidal Behaviors, Suicidal Ideation, and Mental Health in US Youths. PG - 219-228 LID - 10.1001/jama.2025.7829 [doi] AB - IMPORTANCE: Increasing child and adolescent use of social media, video games, and mobile phones has raised concerns about potential links to youth mental health problems. Prior research has largely focused on total screen time rather than longitudinal addictive use trajectories. OBJECTIVES: To identify trajectories of addictive use of social media, mobile phones, and video games and to examine their associations with suicidal behaviors and ideation and mental health outcomes among youths. DESIGN, SETTING, AND PARTICIPANTS: Cohort study analyzing data from baseline through year 4 follow-up in the Adolescent Brain Cognitive Development Study (2016-2022), with population-based samples from 21 US sites. EXPOSURES: Addictive use of social media, mobile phones, and video games using validated child-reported measures from year 2, year 3, and year 4 follow-up surveys. MAIN OUTCOMES AND MEASURES: Suicidal behaviors and ideation assessed using child- and parent-reported information via the Kiddie Schedule for Affective Disorders and Schizophrenia. Internalizing and externalizing symptoms were assessed using the parent-reported Child Behavior Checklist. RESULTS: The analytic sample (n = 4285) had a mean age of 10.0 (SD, 0.6) years; 47.9% were female; and 9.9% were Black, 19.4% Hispanic, and 58.7% White. Latent class linear mixed models identified 3 addictive use trajectories for social media and mobile phones and 2 for video games. Nearly one-third of participants had an increasing addictive use trajectory for social media or mobile phones beginning at age 11 years. In adjusted models, increasing addictive use trajectories were associated with higher risks of suicide-related outcomes than low addictive use trajectories (eg, increasing addictive use of social media had a risk ratio of 2.14 [95% CI, 1.61-2.85] for suicidal behaviors). High addictive use trajectories for all screen types were associated with suicide-related outcomes (eg, high-peaking addictive use of social media had a risk ratio of 2.39 [95% CI, 1.66-3.43] for suicidal behaviors). The high video game addictive use trajectory showed the largest relative difference in internalizing symptoms (T score difference, 2.03 [95% CI, 1.45-2.61]), and the increasing social media addictive use trajectory for externalizing symptoms (T score difference, 1.05 [95% CI, 0.54-1.56]), compared with low addictive use trajectories. Total screen time at baseline was not associated with outcomes. CONCLUSIONS AND RELEVANCE: High or increasing trajectories of addictive use of social media, mobile phones, or video games were common in early adolescents. Both high and increasing addictive screen use trajectories were associated with suicidal behaviors and ideation and worse mental health. FAU - Xiao, Yunyu AU - Xiao Y AD - Department of Population Health Sciences, Weill Cornell Medicine/NewYork-Presbyterian, New York, New York. FAU - Meng, Yuan AU - Meng Y AD - Department of Population Health Sciences, Weill Cornell Medicine/NewYork-Presbyterian, New York, New York. FAU - Brown, Timothy T AU - Brown TT AD - School of Public Health, University of California, Berkeley. FAU - Keyes, Katherine M AU - Keyes KM AD - Columbia University Mailman School of Public Health, New York, New York. FAU - Mann, J John AU - Mann JJ AD - Departments of Psychiatry and Radiology, Irving Medical Center, Columbia University, New York, New York. AD - Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York. LA - eng GR - RF1 MH134649/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PL - United States TA - JAMA JT - JAMA JID - 7501160 SB - IM CIN - JAMA. 2025 Jul 15;334(3):214-216. doi: 10.1001/jama.2025.8135. PMID: 40531495 MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Behavior, Addictive/epidemiology/psychology MH - Cell Phone/statistics & numerical data MH - Cohort Studies MH - *Mental Health/statistics & numerical data MH - *Screen Time MH - Social Media/statistics & numerical data MH - *Suicidal Ideation MH - Suicide, Attempted/statistics & numerical data MH - United States/epidemiology MH - Video Games/statistics & numerical data MH - Follow-Up Studies MH - Child Behavior/psychology MH - Adolescent Behavior/psychology MH - Surveys and Questionnaires/statistics & numerical data PMC - PMC12177733 COIS- Conflict of Interest Disclosures: Dr Mann reports receipt of royalties for commercial use of the Columbia-Suicide Severity Rating Scale from the Research Foundation for Mental Hygiene and the Columbia Pathways App from Columbia University. No other disclosures were reported. EDAT- 2025/06/18 14:20 MHDA- 2025/07/15 12:29 PMCR- 2025/12/18 CRDT- 2025/06/18 11:34 PHST- 2025/07/15 12:29 [medline] PHST- 2025/06/18 14:20 [pubmed] PHST- 2025/06/18 11:34 [entrez] PHST- 2025/12/18 00:00 [pmc-release] AID - 2835481 [pii] AID - joi250036 [pii] AID - 10.1001/jama.2025.7829 [doi] PST - ppublish SO - JAMA. 2025 Jul 15;334(3):219-228. doi: 10.1001/jama.2025.7829. PMID- 40528200 OWN - NLM STAT- MEDLINE DCOM- 20250617 LR - 20260811 IS - 1479-5876 (Electronic) IS - 1479-5876 (Linking) VI - 23 IP - 1 DP - 2025 Jun 17 TI - The efficacy of physiological parameters in assessing the clustering of cardiovascular risk factors (CCRF) among children and adolescents. PG - 664 LID - 10.1186/s12967-025-06182-2 [doi] LID - 664 AB - BACKGROUND: Body mass index z-score (BMI-Z) and waist-to-height ratio (WHtR) are widely used to assess children's nutrition and metabolic status. Neck-to-height ratio (NHtR), triglyceride-glucose index (TyG), visceral adiposity index (VAI), and Chinese visceral adiposity index (CVAI) have recently been used to assess the development of cardiovascular and cerebrovascular risks. However, their effectiveness in assessing the clustering of cardiometabolic risk factors (CCRF) is not yet clear. This study aims to explore the predictive ability of physiological parameters for CCRF, which could provide evidence for the early identification of cardiometabolic risks in children. METHODS: The children who underwent health examinations were included, and BMI-Z, percentage of body fat (PBF), WHtR, NHtR, VAI, CVAI, and TyG were calculated. Spearman correlation analysis was applied to explore the relationship between physiological parameters and metabolic indices. Binary logistic regression analysis was employed to assess the association between physiological parameters and metabolic risk factors. The receiver operating characteristic (ROC) analysis was utilized to estimate the ability of physiological parameters to CCRF. The Delong tests were utilized to compare the differences and determine predictive superiority. RESULTS: A total of 9039 children and adolescents were included, among whom 37.9% were overweight or obese. Significant correlation between physiological parameters and metabolic parameters. All the seven physiological parameters significantly increased the CCRF, among which the CVAI model had the best effect after adjusting for age and gender (R(2) = 0.398, AIC = 7738). The ROC curve showed that the accuracy of WHtR in predicting CCRF was the highest in boys (area under curve (AUC) = 0.837). The accuracy of CVAI in predicting CCRF in girls was the highest (AUC = 0.826). CONCLUSION: Physiological parameters could be used to assess CCRF among children and adolescents, among which WHtR has the highest prediction efficiency in boys, and CVAI and WHtR have strong reliability in girls. CI - (c) 2025. The Author(s). FAU - Yan, Wu AU - Yan W AUID- ORCID: 0000-0002-3943-774X AD - Department of Children Health Care, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. FAU - Peng, Luting AU - Peng L AD - Department of Children Health Care, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. FAU - Shi, Yanan AU - Shi Y AD - Department of Children Health Care, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. FAU - Cao, Mengyao AU - Cao M AD - Department of Children Health Care, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. FAU - Zheng, Qingqing AU - Zheng Q AD - Department of Children Health Care, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. FAU - Gao, Shenghu AU - Gao S AD - Department of Children Health Care, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. FAU - Liu, Qianqi AU - Liu Q AD - Department of Children Health Care, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. FAU - Li, Xiaonan AU - Li X AD - Department of Children Health Care, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. xiaonan6189@163.com. AD - Institute of Pediatric Research, Nanjing Medical University, Nanjing, 210029, China. xiaonan6189@163.com. LA - eng GR - 81773421/National Natural Science Foundation of China/ GR - YKK22156/Nanjing Medical Science and Technology Development Project/ GR - F202213/Maternal and Child Health Research Project of Jiangsu Province/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250617 PL - England TA - J Transl Med JT - Journal of translational medicine JID - 101190741 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - Adolescent MH - *Heart Disease Risk Factors MH - *Cardiovascular Diseases/physiopathology/epidemiology MH - ROC Curve MH - Cluster Analysis MH - Body Mass Index MH - Risk Factors PMC - PMC12172311 OTO - NOTNLM OT - Children OT - Clustering of cardiovascular risk factors OT - Obesity OT - Physiological parameters COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Medical Ethics Committee of Children's Hospital of Nanjing Medical University (201603004-1). Informed consent was obtained from all subjects involved in the study. Consent for publication: Not applicable. Competing interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/06/18 00:29 MHDA- 2025/06/18 00:30 PMCR- 2025/06/17 CRDT- 2025/06/17 23:35 PHST- 2024/02/25 00:00 [received] PHST- 2025/01/30 00:00 [accepted] PHST- 2025/06/18 00:30 [medline] PHST- 2025/06/18 00:29 [pubmed] PHST- 2025/06/17 23:35 [entrez] PHST- 2025/06/17 00:00 [pmc-release] AID - 10.1186/s12967-025-06182-2 [pii] AID - 6182 [pii] AID - 10.1186/s12967-025-06182-2 [doi] PST - epublish SO - J Transl Med. 2025 Jun 17;23(1):664. doi: 10.1186/s12967-025-06182-2. PMID- 40527395 OWN - NLM STAT- MEDLINE DCOM- 20250727 LR - 20260623 IS - 1559-2030 (Electronic) IS - 1551-7144 (Linking) VI - 155 DP - 2025 Aug TI - Effects of one month of intermittent fasting on the blood microbiome in healthy volunteers (OMIF): A randomized controlled crossover study protocol. PG - 107986 LID - S1551-7144(25)00180-6 [pii] LID - 10.1016/j.cct.2025.107986 [doi] AB - BACKGROUND: It is hypothesized that the presence of microorganisms in the gut is reflected in circulating blood through small DNA fragments resulting from the degradation of these organisms. Cross-sectional studies have not yet provided a definitive answer regarding the validity of this hypothesis, and the potential presence of a so-called common blood-microbiome remains highly controversial. Both bioinformatical pipelines (which may produce false-positive results) and environmental contamination may obscure the less than 5 % microbial DNA that is postulated to be present within the total blood DNA. METHOD/DESIGN: This study aims to validate the existence of the blood microbiome using one month of intermittent fasting (OMIF). Through a prospective, randomized, controlled cross-over trial, we will evaluate the effect of OMIF on the composition and function of the blood microbiome in healthy volunteers, with secondary outcomes on clarifying the relationship between the gut and blood microbiome. Healthy volunteers aged 18-65 will be enrolled. All volunteers will undergo OMIF, a washout period and an ad libitum diet for another month, with the order of the interventions assigned randomly. We will assess the dynamics in blood microbiome in response to OMIF versus those seen during an ad libitum diet, using shotgun sequencing. Physiological changes will be monitored A dietary recall interview will be conducted during the trial to evaluate energy intake, and movement data collected from Health App will be used to assess changes in physical activity. CONCLUSION: If successful, this trial provides a proof-of-concept study documenting the existence of a bona fide blood microbiome. CLINICAL TRIAL REGISTRATION: NCT06678516. CI - Copyright (c) 2024. Published by Elsevier Inc. FAU - Su, Junhong AU - Su J AD - Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center Rotterdam, PO Box 2040, NL-3000 CA Rotterdam, the Netherlands. FAU - Hansen, Bettina E AU - Hansen BE AD - Toronto Centre for Liver Disease, University Health Network, & Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada; Department of Epidemiology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands. FAU - Ma, Zhongren AU - Ma Z AD - Biomedical Research Center, Northwest Minzu University, Lanzhou, China. FAU - Peppelenbosch, Maikel P AU - Peppelenbosch MP AD - Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center Rotterdam, PO Box 2040, NL-3000 CA Rotterdam, the Netherlands. Electronic address: m.peppelenbosch@erasmusmc.nl. LA - eng SI - ClinicalTrials.gov/NCT06678516 PT - Clinical Trial Protocol PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250615 PL - United States TA - Contemp Clin Trials JT - Contemporary clinical trials JID - 101242342 SB - IM MH - Humans MH - Cross-Over Studies MH - *Fasting/blood/physiology MH - Adult MH - Healthy Volunteers MH - Male MH - Middle Aged MH - Prospective Studies MH - *Gastrointestinal Microbiome MH - Young Adult MH - Female MH - Randomized Controlled Trials as Topic MH - Adolescent MH - *Microbiota MH - Aged MH - Intermittent Fasting OTO - NOTNLM OT - Blood microbiome OT - Gut microbiome OT - Healthy volunteers OT - Intermittent fasting COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Maikel Peppelenbosch reports financial support was provided by The Foundation for Liver and Gastrointestinal Research. Maikel Peppelenbosch reports financial support was provided by Dutch Research Council. Maikel Peppelenbosch reports financial support was provided by Hualing Dairy Co. LTD. Maikel Peppelenbosch reports financial support was provided by Netherlands Organisation for Health Research and Development. Maikel Peppelenbosch reports a relationship with Pfizer Inc. that includes: speaking and lecture fees. Maikel Peppelenbosch reports a relationship with Netherlands Organisation for Health Research and Development that includes: consulting or advisory. Maikel Peppelenbosch reports a relationship with Narodowe Centrum Nauki that includes: consulting or advisory. Maikel Peppelenbosch reports a relationship with Czech Science Foundation that includes: consulting or advisory. Maikel Peppelenbosch reports a relationship with European Commission (Brussel) that includes: consulting or advisory. Maikel Peppelenbosch reports a relationship with European Science Foundation that includes: consulting or advisory. Maikel Peppelenbosch reports a relationship with VVD that includes: consulting or advisory. Maikel Peppelenbosch is director of the Batavian Society of Experimental Philosophy and has an appointment as a lecturer at the Technical University of Delft. He is also member of the editorial board of Journal of Crohn's and Colitis, Cells and Biology If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/06/18 00:28 MHDA- 2025/07/28 08:44 CRDT- 2025/06/17 19:10 PHST- 2025/01/10 00:00 [received] PHST- 2025/04/22 00:00 [revised] PHST- 2025/06/13 00:00 [accepted] PHST- 2025/07/28 08:44 [medline] PHST- 2025/06/18 00:28 [pubmed] PHST- 2025/06/17 19:10 [entrez] AID - S1551-7144(25)00180-6 [pii] AID - 10.1016/j.cct.2025.107986 [doi] PST - ppublish SO - Contemp Clin Trials. 2025 Aug;155:107986. doi: 10.1016/j.cct.2025.107986. Epub 2025 Jun 15. PMID- 40527268 OWN - NLM STAT- MEDLINE DCOM- 20250717 LR - 20250717 IS - 1872-8464 (Electronic) IS - 0165-5876 (Linking) VI - 195 DP - 2025 Aug TI - Construction of a nomogram for individualized prediction of obstructive sleep apnea syndrome risk in snoring children. PG - 112431 LID - S0165-5876(25)00218-6 [pii] LID - 10.1016/j.ijporl.2025.112431 [doi] AB - OBJECTIVE: To develop and validate a nomogram for the individualized prediction of obstructive sleep apnea syndrome (OSAS) risk in children presenting with snoring. METHODS: This retrospective study included 294 children with snoring admitted to our hospital between November 2022 and November 2024. Patients were randomly allocated into a modeling group (n = 206) and a validation group (n = 88). Based on the diagnosis of OSAS, patients in each group were further categorized into OSAS and non-OSAS subgroups. Logistic regression analysis was employed to identify independent risk factors for OSAS. R software was utilized to construct the nomogram. The model's discrimination was assessed using the Receiver Operating Characteristic (ROC) curve and Area Under the Curve (AUC). Calibration was evaluated using the Hosmer-Lemeshow (H-L) test. Decision Curve Analysis (DCA) was performed to determine the clinical utility of the nomogram. RESULTS: Among the 294 patients, 89 (30.27 %) were diagnosed with OSAS. Within the modeling group (n = 206), 62 children (30.10 %) developed OSAS. Multivariate logistic regression analysis identified obesity, neck circumference, neck circumference-to-height ratio, tonsillar hypertrophy, adenoid hypertrophy, and a history of rhinitis/sinusitis as significant independent risk factors for OSAS (P < 0.05). The nomogram demonstrated excellent discrimination with an AUC of 0.964 in the modeling group and 0.967 in the validation group. Good calibration was confirmed by the H-L test in both the modeling group (x(2) = 7.045, P = 0.722) and the validation group (x(2) = 7.045, P = 0.725). DCA indicated that the nomogram provided substantial clinical net benefit across a wide range of threshold probabilities (approximately 0.10-0.95) for predicting OSAS in snoring children. CONCLUSION: Obesity, neck circumference, neck circumference-to-height ratio, tonsillar hypertrophy, adenoid hypertrophy, and a history of rhinitis/sinusitis are significant predictors of OSAS in snoring children. The nomogram developed based on these factors serves as a reliable and clinically applicable tool for predicting the individual risk of OSAS in this population. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Zheng, Yingsong AU - Zheng Y AD - Department of ENT Head and Neck Surgery, Wenzhou Central Hospital, Wenzhou City 325000, Zhejiang Province, China. FAU - Wu, Jieru AU - Wu J AD - Department of Traditional Chinese Medicine, Wenzhou Central Hospital, Wenzhou City 325000, Zhejiang Province, China. FAU - Xu, Yaoqi AU - Xu Y AD - Department of Traditional Chinese Medicine, Wenzhou Central Hospital, Wenzhou City 325000, Zhejiang Province, China. FAU - Lin, Feifei AU - Lin F AD - Department of Traditional Chinese Medicine, Wenzhou Central Hospital, Wenzhou City 325000, Zhejiang Province, China. FAU - Xie, Shangren AU - Xie S AD - Department of Traditional Chinese Medicine, Wenzhou Central Hospital, Wenzhou City 325000, Zhejiang Province, China. Electronic address: ghingh198707@sina.com. LA - eng PT - Journal Article PT - Validation Study DEP - 20250613 PL - Ireland TA - Int J Pediatr Otorhinolaryngol JT - International journal of pediatric otorhinolaryngology JID - 8003603 SB - IM MH - Humans MH - *Sleep Apnea, Obstructive/diagnosis/etiology/epidemiology MH - *Nomograms MH - Male MH - Female MH - *Snoring/etiology/complications MH - Retrospective Studies MH - Child MH - Risk Factors MH - Risk Assessment/methods MH - Child, Preschool MH - ROC Curve MH - Logistic Models MH - Neck OTO - NOTNLM OT - Nomogram OT - Obstructive sleep apnea syndrome OT - Prediction model OT - Risk factors OT - Snoring COIS- Declaration of competing interest Authors declared no conflict of interest. EDAT- 2025/06/18 00:28 MHDA- 2025/07/18 01:41 CRDT- 2025/06/17 18:10 PHST- 2025/02/25 00:00 [received] PHST- 2025/05/06 00:00 [revised] PHST- 2025/06/12 00:00 [accepted] PHST- 2025/07/18 01:41 [medline] PHST- 2025/06/18 00:28 [pubmed] PHST- 2025/06/17 18:10 [entrez] AID - S0165-5876(25)00218-6 [pii] AID - 10.1016/j.ijporl.2025.112431 [doi] PST - ppublish SO - Int J Pediatr Otorhinolaryngol. 2025 Aug;195:112431. doi: 10.1016/j.ijporl.2025.112431. Epub 2025 Jun 13. PMID- 40526710 OWN - NLM STAT- MEDLINE DCOM- 20250617 LR - 20250814 IS - 1557-0657 (Electronic) IS - 1049-8931 (Print) IS - 1049-8931 (Linking) VI - 34 IP - 2 DP - 2025 Jun TI - Understanding Youth Online Experiences and Mental Health: Development and Validation of the Digital Activity and Feelings Inventory (DAFI). PG - e70028 LID - 10.1002/mpr.70028 [doi] LID - e70028 AB - OBJECTIVES: We created the Digital Activity and Feelings Inventory (DAFI) to measure youth digital activities and the psychological reactions they evoke, established its psychometric properties and tested its validity in predicting mental health relative to screen time estimates. METHODS: An initial pool of items was generated using the existing research on youth digital activity and mental health and further refined via consultations with experts and young people (online youth panel sessions, n = 14). The participants (n = 383, mean age = 19 years) completed the resulting DAFI alongside established measures of depression, anxiety, wellbeing, and screen time. The DAFI factor structure, reliability and predictive validity were tested. RESULTS: Exploratory factor analyses identified five digital activity subscales: Risky Content, Risky Interactions, Social Comparison, Leisure Activities and Social Engagement and three psychological reactions subscales: Negative Self-Reactions, Negative Stress Reactions, and Positive Reactions. Internal consistency and test-retest reliability were high. Social Comparison and Negative Self-Reactions, but not screen time, independently predicted depression and anxiety symptoms. Positive Reactions, lack of Negative Self-Reactions, lower screen time and Social Engagement predicted wellbeing. CONCLUSION: The DAFI is a reliable measure of digital activities and associated psychological reactions and predicts youth mental health better than screen time. CI - (c) 2025 The Author(s). International Journal of Methods in Psychiatric Research published by John Wiley & Sons Ltd. FAU - Kostyrka-Allchorne, Katarzyna AU - Kostyrka-Allchorne K AD - Department of Psychology, School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK. FAU - Bourgaize, Jake AU - Bourgaize J AD - Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. AD - Clinical Outcome Solutions, Folkestone, UK. FAU - Murray, Aja AU - Murray A AD - School of Psychology, University of Edinburgh, Edinburgh, UK. FAU - Stoilova, Mariya AU - Stoilova M AD - Department of Media and Communications, London School of Economics and Political Science, London, UK. FAU - Abbas, Iqra AU - Abbas I AD - Department of Psychology, School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK. FAU - Bridgwood, Amy AU - Bridgwood A AD - Department of Psychology, School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK. FAU - Azeri, Eliz AU - Azeri E AD - Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. FAU - Hollis, Chris AU - Hollis C AD - National Institute of Health Research (NIHR) MindTech MedTech Research Centre, Institute of Mental Health, School of Medicine, University of Nottingham, Nottingham, UK. FAU - Townsend, Ellen AU - Townsend E AD - School of Psychology, University of Nottingham, Nottingham, UK. FAU - Livingstone, Sonia AU - Livingstone S AD - Department of Media and Communications, London School of Economics and Political Science, London, UK. FAU - Sonuga-Barke, Edmund J S AU - Sonuga-Barke EJS AD - Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. CN - Digital Youth Research Programme LA - eng GR - MR/ W002450/1/MRC_/Medical Research Council/United Kingdom GR - National Institute for Health and Care Research/ GR - Maudsley Biomedical Research Centre/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study PL - United States TA - Int J Methods Psychiatr Res JT - International journal of methods in psychiatric research JID - 9111433 SB - IM EIN - Int J Methods Psychiatr Res. 2025 Sep;34(3):e70030. doi: 10.1002/mpr.70030. PMID: 40677013 MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - *Psychometrics/standards/instrumentation MH - Reproducibility of Results MH - Adult MH - *Anxiety/diagnosis MH - *Depression/diagnosis MH - *Psychiatric Status Rating Scales/standards MH - *Mental Health MH - *Screen Time PMC - PMC12173090 OTO - NOTNLM OT - adolescent OT - digital activity OT - mental health OT - screen time OT - wellbeing COIS- The authors declare no conflicts of interest. EDAT- 2025/06/17 18:26 MHDA- 2025/06/17 18:27 PMCR- 2025/06/17 CRDT- 2025/06/17 13:45 PHST- 2025/04/10 00:00 [revised] PHST- 2025/04/10 00:00 [received] PHST- 2025/06/09 00:00 [accepted] PHST- 2025/06/17 18:27 [medline] PHST- 2025/06/17 18:26 [pubmed] PHST- 2025/06/17 13:45 [entrez] PHST- 2025/06/17 00:00 [pmc-release] AID - MPR70028 [pii] AID - 10.1002/mpr.70028 [doi] PST - ppublish SO - Int J Methods Psychiatr Res. 2025 Jun;34(2):e70028. doi: 10.1002/mpr.70028. PMID- 40524700 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250618 IS - 2589-5559 (Electronic) IS - 2589-5559 (Linking) VI - 7 IP - 7 DP - 2025 Jul TI - Identification of pediatric MASLD using insulin resistance indices. PG - 101419 LID - 10.1016/j.jhepr.2025.101419 [doi] LID - 101419 AB - BACKGROUND & AIMS: We investigated the triglyceride-to-high density lipoprotein (HDL) ratio (TG/HDL), triglyceride-glucose index (TyG), single-point insulin sensitivity estimator (SPISE), and metabolic score for insulin resistance (METS-IR) as potential predictors of pediatric metabolic dysfunction-associated steatotic liver disease (MASLD) by addressing the limited research on insulin-resistance markers in this population. METHODS: This cross-sectional study included data from 1,150 and 260 youths from the National Health and Nutrition Examination Survey (NHANES) and a real-world clinic, respectively. Hepatic steatosis was assessed using transient elastography and abdominal sonography. Logistic regression analysis was performed using MASLD as the dependent variable. Receiver operating characteristic (ROC) curves were used to evaluate predictability. RESULTS: The MASLD group had higher TG/HDL, TyG, METS-IR, and obesity proportions but lower SPISE than the normal group in both NHANES and real-world data. All markers were significantly related to MASLD in logistic regression analyses, even after adjusting for age and sex, in both the NHANES and real-world clinic data (all p <0.001). The areas under the ROC curves (AUCs) for SPISE and METS-IR were 0.91 and 0.91 in the total group, 0.92 and 0.92 in the male group, and 0.90 and 0.89 in the female group, respectively-all higher than those for TG/HDL and TyG in the NHANES dataset (all p <0.001). In the real-world clinical data, the AUCs of SPISE and METS-IR were significantly higher than those of TG/HDL and TyG in the total and male groups (all p <0.001). In the female group, the AUC for SPISE was significantly higher than that for TG/HDL or TyG. CONCLUSIONS: METS-IR and SPISE are effective, non-invasive markers for predicting pediatric MASLD, which offer valuable tools for early detection and improved clinical management. IMPACT AND IMPLICATIONS: The increasing prevalence of pediatric metabolic dysfunction-associated steatotic liver disease (MASLD) and its strong association with cardiometabolic risk factors underscore the need for effective early detection tools. Our study demonstrates that single-point insulin sensitivity estimator (SPISE) and metabolic score for insulin resistance (METS-IR) are superior, non-invasive markers for predicting MASLD in children and adolescents, with validated cut-off values applicable to both population-based and real-world clinical settings. These findings are particularly relevant for clinicians and healthcare policymakers, as they provide practical, easily accessible screening tools derived from routine laboratory tests, aiding in the early identification and risk stratification of pediatric MASLD. However, given the study's retrospective design and variations in diagnostic methods across datasets, further validation in larger, diverse cohorts is warranted to refine age-specific cut-off values and optimize screening approaches. CI - (c) 2025 The Author(s). FAU - Song, Kyungchul AU - Song K AD - Department of Pediatrics, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Republic of Korea. FAU - Lee, Eunju AU - Lee E AD - Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Lee, Hye Sun AU - Lee HS AD - Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Youn, Young Hoon AU - Youn YH AD - Department of Healthcare Research Team, Health Promotion Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Baik, Su Jung AU - Baik SJ AD - Department of Healthcare Research Team, Health Promotion Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Shin, Hyun Joo AU - Shin HJ AD - Department of Radiology, Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, Republic of Korea. FAU - Chae, Hyun Wook AU - Chae HW AD - Department of Pediatrics, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Republic of Korea. FAU - Lee, Ji-Won AU - Lee JW AD - Department of Family Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Republic of Korea. AD - Institute for Innovation in Digital Healthcare, Yonsei University, Seoul, Republic of Korea. FAU - Kwon, Yu-Jin AU - Kwon YJ AD - Department of Family Medicine, Yonsei University College of Medicine, Yongin Severance Hospital, Yongin-si, Republic of Korea. LA - eng PT - Journal Article DEP - 20250403 PL - Netherlands TA - JHEP Rep JT - JHEP reports : innovation in hepatology JID - 101761237 PMC - PMC12167474 OTO - NOTNLM OT - Adolescent OT - Biomarkers OT - Child OT - Insulin resistance OT - Metabolic dysfunction-associated steatotic liver disease COIS- The authors declare no conflicts of interest that pertain to this work. Please refer to the accompanying ICMJE disclosure forms for further details. EDAT- 2025/06/17 06:26 MHDA- 2025/06/17 06:27 PMCR- 2025/04/03 CRDT- 2025/06/17 04:14 PHST- 2024/11/18 00:00 [received] PHST- 2025/03/20 00:00 [revised] PHST- 2025/03/31 00:00 [accepted] PHST- 2025/06/17 06:27 [medline] PHST- 2025/06/17 06:26 [pubmed] PHST- 2025/06/17 04:14 [entrez] PHST- 2025/04/03 00:00 [pmc-release] AID - S2589-5559(25)00096-5 [pii] AID - 101419 [pii] AID - 10.1016/j.jhepr.2025.101419 [doi] PST - epublish SO - JHEP Rep. 2025 Apr 3;7(7):101419. doi: 10.1016/j.jhepr.2025.101419. eCollection 2025 Jul. PMID- 40524204 OWN - NLM STAT- MEDLINE DCOM- 20250617 LR - 20260811 IS - 2042-6410 (Electronic) IS - 2042-6410 (Linking) VI - 16 IP - 1 DP - 2025 Jun 16 TI - Psychosocial and clinical characteristics in Takotsubo syndrome. PG - 42 LID - 10.1186/s13293-025-00729-0 [doi] LID - 42 AB - BACKGROUND: Takotsubo Syndrome (TTS) is an acute form of heart failure that disproportionately impacts post-menopausal women. The brain-heart connection is considered a pathway for TTS pathophysiology leading to investigations of the role of psychological, psychosocial, and personality factors in TTS. OBJECTIVES: We compare psychosocial characteristics among a subset of individuals with confirmed TTS and those who had symptoms adjudicated as non-TTS in our online Takotsubo registry (n = 104). We also evaluate differences in TTS clinical characteristics among those with and without symptoms of PTSD and depression. METHODS: The Smidt Heart Institute Takotsubo registry enrolls individuals with a history of TTS sourced through physician referrals, medical records review, peer- and self-referrals. Psychosocial characteristics were assessed using questionnaires validated in acute coronary syndrome populations. Hedge's g effect sizes were computed to compare differences in perceived stress, depression symptoms, and post-traumatic stress disorder (PTSD) symptoms relative to TTS status. RESULTS: Compared to participants confirmed to be non-TTS, those with adjudication-confirmed TTS had worse mean psychosocial scores (indicative of worse psychosocial characteristics). After adjusting for age at event, BMI, race, and smoking status, the Hedge's g effect size for depressive symptoms was moderate [0.60 (-0.03, 1.22)] while effect sizes for other psychosocial measures were minimal (Trait anxiety: [0.01 (-0.58, 0.60)], PTSD symptoms [0.13 (-0.46, 0.73)], perceived stress [0.06 (-0.53, 0.65)]. Effect sizes were relatively lower following adjustment, largely driven by participants' age at first event. Individuals with elevated PTSD symptoms were significantly younger at their first TTS event compared to those with minimal or no symptoms (54 +/- 8 vs. 61 +/- 10; p = 0.005). QTc was relatively longer among individuals with elevated PTSD symptoms (483 +/- 40 msec vs. 465 +/- 32 msec; p = 0.08) and elevated depressive symptoms (481 +/- 33 msec vs. 464 +/- 36 msec; p = 0.07), although the differences were not statistically significant. CONCLUSIONS: Psychosocial characteristics including PTSD, depression, and stress are common among women with TTS, and age at the time of TTS event is a potentially important moderator of this relationship. We did not find Trait-anxiety or early childhood trauma to be associated with TTS in our cohort. CI - (c) 2025. The Author(s). FAU - Obrutu, Okezi AU - Obrutu O AD - Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, 127 S. San Vicente Blvd AHSP Suite A3206, Los Angeles, CA, 90048, USA. FAU - Cui, Yujie AU - Cui Y AD - Biostatistics and Bioinformatics Research Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA. FAU - Maughan, Jenna AU - Maughan J AD - Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, 127 S. San Vicente Blvd AHSP Suite A3206, Los Angeles, CA, 90048, USA. FAU - Marano, Paul AU - Marano P AD - Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. FAU - Wei, Janet AU - Wei J AD - Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, 127 S. San Vicente Blvd AHSP Suite A3206, Los Angeles, CA, 90048, USA. FAU - Gulati, Martha AU - Gulati M AD - Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, 127 S. San Vicente Blvd AHSP Suite A3206, Los Angeles, CA, 90048, USA. FAU - Lauzon, Marie AU - Lauzon M AD - Biostatistics and Bioinformatics Research Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA. FAU - Herscovici, Romana AU - Herscovici R AD - The Lev Leviev Heart Center, Chaim Sheba Medical Center, Tel-Hashomer, Israel. FAU - Shufelt, Chrisandra AU - Shufelt C AD - Women's Health Research Center, Mayo Clinic, Jacksonville, FL, USA. FAU - Rojas, Natalie AU - Rojas N AD - Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, 127 S. San Vicente Blvd AHSP Suite A3206, Los Angeles, CA, 90048, USA. FAU - Tjoe, Benita AU - Tjoe B AD - Queen's Medical Center, Honolulu, HI, USA. FAU - Rutledge, Thomas AU - Rutledge T AD - VA San Diego Healthcare System, San Diego, CA, USA. AD - Department of Psychiatry, University of California, San Diego, CA, USA. FAU - Bairey Merz, C Noel AU - Bairey Merz CN AD - Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, 127 S. San Vicente Blvd AHSP Suite A3206, Los Angeles, CA, 90048, USA. noel.baireymerz@cshs.org. LA - eng PT - Journal Article DEP - 20250616 PL - England TA - Biol Sex Differ JT - Biology of sex differences JID - 101548963 SB - IM MH - Humans MH - Female MH - Middle Aged MH - Aged MH - *Takotsubo Cardiomyopathy/psychology/physiopathology MH - *Depression/psychology MH - *Stress Disorders, Post-Traumatic/psychology MH - Male MH - Registries MH - Stress, Psychological PMC - PMC12168290 OAB - Takotsubo syndrome (TTS) is a form of heart failure that is linked to emotional and physical stressors. It commonly affects women after menopause. Literature suggests that the brain and heart are connected in this illness, so we studied how stress, depression, and other psychological factors might play a role. This study compared people with TTS to those with similar symptoms who didn't have TTS. We used surveys to measure stress, depression, Post-Traumatic Stress Disorder (PTSD), and other psychosocial characteristics when participants enrolled into the study. Clinical characteristics were determined from a retrospective review of participants' medical records during their TTS event.We found that individuals with confirmed TTS had scores that were representative of higher levels of depression, PTSD, and perceived stress compared to the group without TTS. Younger people with TTS were more likely to have PTSD symptoms. On average, people with PTSD symptoms had their first TTS event at age 54, while others had it at age 61. Depression and PTSD seemed to have a more considerable effect on TTS than anxiety or early-life trauma. The study shows that feelings like stress, depression, and PTSD are common in people with TTS, and age might make a difference in how these feelings affect the heart. Our findings offer additional insight into psychosocial features and associated clinical characteristics in TTS. OABL- eng OTO - NOTNLM OT - Depression OT - PTSD OT - Psychosocial characteristics OT - Stress cardiomyopathy OT - Takotsubo syndrome COIS- Declarations. Ethics approval and consent to participate: Ethical approval for the registry was obtained from Cedars-Sinai Medical Center Institutional Review Board (Ref. No: Pro00053569). Participants completed informed consent forms prior to study enrolment. Consent for publication: Not applicable. Competing interests: Dr. C. Noel Bairey Merz receives consulting fees from iRhythm and SHL Telemedicine. Dr. Martha Gulati serves on the advisory boards of HelloHeart, Esperion, Novartis and New Amsterdam. Dr. Janet Wei served on an advisory board for Abbott Vascular All other authors declare no conflicts of interest. Availability for data and materials: The data underlying this article will be shared on reasonable request to the corresponding author. EDAT- 2025/06/17 00:25 MHDA- 2025/06/17 06:26 PMCR- 2025/06/16 CRDT- 2025/06/16 23:45 PHST- 2025/01/06 00:00 [received] PHST- 2025/06/10 00:00 [accepted] PHST- 2025/06/17 06:26 [medline] PHST- 2025/06/17 00:25 [pubmed] PHST- 2025/06/16 23:45 [entrez] PHST- 2025/06/16 00:00 [pmc-release] AID - 10.1186/s13293-025-00729-0 [pii] AID - 729 [pii] AID - 10.1186/s13293-025-00729-0 [doi] PST - epublish SO - Biol Sex Differ. 2025 Jun 16;16(1):42. doi: 10.1186/s13293-025-00729-0. PMID- 40523473 OWN - NLM STAT- MEDLINE DCOM- 20250712 LR - 20250715 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 68 DP - 2025 Aug TI - Development and validation of new bioimpedance equations to estimate skeletal muscle mass percentage in a white, healthy population. PG - 707-714 LID - S2405-4577(25)00371-7 [pii] LID - 10.1016/j.clnesp.2025.06.025 [doi] AB - BACKGROUND & AIMS: Skeletal muscle mass (SMM) plays a crucial role in overall health, especially in the aging population, and increased fat deposition elevate the risk of frailty and metabolic disorders. Accurate and accessible SMM assessment is essential for identifying and monitoring these risks. Bioelectrical impedance analysis (BIA) devices, widely used for body composition assessment, provide a non-invasive, practical solution; however, the accuracy of BIA measurements can vary significantly compared to dual-energy X-ray absorptiometry (DXA), particularly across different device types and demographic groups. Given the physiological and lifestyle changes that can influence muscle mass across the adult lifespan, there is a growing need for precise, reliable tools to evaluate SMM in a broad adult population. METHODS: We developed novel equations for estimating SMM percentage in a white, healthy population using two different BIA technologies: foot-to-hand device (Akern 101) and hand-to-hand device (TELELAB). These equations were developed to enhance the precision of SMM measurements, calibrating the output to align more closely with DXA values. A sample of 211 individuals (100 women, 111 men) aged 18-65 years was divided into a development group and a validation group to establish and test the predictive reliability of the proposed equations. RESULTS: Bland-Altman analyses revealed minimal fixed bias for both new equations compared to DXA, with substantially reduced mean bias values and lower standard deviations than those observed with use of the original manufacturer's equations. CONCLUSIONS: The new equations effectively minimize the overestimation observed when using the manufacturer's equations, demonstrating an average bias close to zero and enhanced consistency across age and ethnic groups. These optimized equations offer a robust, practical solution for accurate SMM assessment in clinical and research settings across diverse adult populations. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Moya-Amaya, Heliodoro AU - Moya-Amaya H AD - CTS-595 Research Group, Department of Informatics and Sports, Universidad Pablo de Olavide, Seville, Spain. FAU - Rojano-Ortega, Daniel AU - Rojano-Ortega D AD - CTS-595 Research Group, Department of Informatics and Sports, Universidad Pablo de Olavide, Seville, Spain. FAU - Molina-Lopez, Antonio AU - Molina-Lopez A AD - CTS-595 Research Group, Department of Informatics and Sports, Universidad Pablo de Olavide, Seville, Spain; Department of Nutrition of Udinese Calcio Spa, Italy. FAU - Berral-Aguilar, Antonio Jesus AU - Berral-Aguilar AJ AD - CTS-595 Research Group, Department of Informatics and Sports, Universidad Pablo de Olavide, Seville, Spain. FAU - Portolan, Alessandro AU - Portolan A AD - Unifarco SPA, Santa Giustina, BL, Italy. FAU - Berral-de la Rosa, Francisco Jose AU - Berral-de la Rosa FJ AD - CTS-595 Research Group, Department of Informatics and Sports, Universidad Pablo de Olavide, Seville, Spain. Electronic address: fjberde@upo.es. LA - eng PT - Journal Article PT - Validation Study DEP - 20250614 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - Absorptiometry, Photon MH - *Body Composition MH - *Electric Impedance MH - *Muscle, Skeletal/physiology MH - Reproducibility of Results MH - *White People/statistics & numerical data MH - Healthy Volunteers/statistics & numerical data OTO - NOTNLM OT - Bioelectrical impedance OT - Body composition OT - Health OT - Muscle mass COIS- Declaration of competing interest The authors declare no conflict of interest. EDAT- 2025/06/17 00:25 MHDA- 2025/07/13 03:34 CRDT- 2025/06/16 19:12 PHST- 2025/02/25 00:00 [received] PHST- 2025/06/01 00:00 [revised] PHST- 2025/06/09 00:00 [accepted] PHST- 2025/07/13 03:34 [medline] PHST- 2025/06/17 00:25 [pubmed] PHST- 2025/06/16 19:12 [entrez] AID - S2405-4577(25)00371-7 [pii] AID - 10.1016/j.clnesp.2025.06.025 [doi] PST - ppublish SO - Clin Nutr ESPEN. 2025 Aug;68:707-714. doi: 10.1016/j.clnesp.2025.06.025. Epub 2025 Jun 14. PMID- 40523309 OWN - NLM STAT- MEDLINE DCOM- 20251118 LR - 20260130 IS - 2168-3824 (Electronic) IS - 0270-1367 (Linking) VI - 96 IP - 4 DP - 2025 Dec TI - Creativity in Motion: How a Single Aerobic Exercise Session Affects Divergent Creative Thinking. PG - 812-818 LID - 10.1080/02701367.2025.2513362 [doi] AB - Creativity, a key cognitive process for innovation, involves generating novel and valuable ideas. While aerobic exercise is linked to cognitive benefits, its effects on creative thinking remain unclear. Evidence suggests that both single and consecutive exercise sessions may enhance creative thinking, yet the optimal intensity and timing of exercise for benefiting creative thinking have not been fully explored. This study examined whether a 20 minute moderate-to-vigorous cycle session influences divergent creative thinking, and how timing of assessment affects performance. Fifty-one young adults completed Guilford's Alternate Uses Task (AUT) under three conditions: post-exercise, during exercise, or control (after watching an exercise video). AUT performance was measured by fluency (number of ideas), validity (practicality of ideas), flexibility (number of categories), and originality (creativity ratings on a 1-5 scale). No significant differences between the control and post-exercise groups were found. However, those assessed during exercise showed lower originality, fluency, and validity, likely due to dual-task interference. These findings suggest that a 20 minute aerobic session does not enhance creativity and may hinder it when assessed during exercise. The study highlights the need for further research to clarify how exercise intensity, duration, and timing impact creative thinking to optimize potential cognitive benefits. FAU - Sodhi, Kabir AU - Sodhi K AD - Western University. FAU - Marshall, Samantha AU - Marshall S AUID- ORCID: 0000-0002-1100-7350 AD - Western University. FAU - Jeyarajan, Gianna AU - Jeyarajan G AD - Western University. FAU - Hanna Al-Shaikh, Jennifer AU - Hanna Al-Shaikh J AD - Western University. FAU - Gabiazon, Raphael AU - Gabiazon R AUID- ORCID: 0009-0008-6575-4993 AD - Western University. FAU - Nagamatsu, Lindsay S AU - Nagamatsu LS AUID- ORCID: 0000-0002-5444-8965 AD - Western University. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250616 PL - United States TA - Res Q Exerc Sport JT - Research quarterly for exercise and sport JID - 8006373 SB - IM MH - Humans MH - *Creativity MH - *Exercise/psychology/physiology MH - Male MH - Young Adult MH - Female MH - *Thinking MH - Adult MH - Time Factors MH - Adolescent MH - Cognition OTO - NOTNLM OT - Aerobic exercise OT - cognition OT - creativity OT - young adults EDAT- 2025/06/16 18:25 MHDA- 2025/11/19 00:26 CRDT- 2025/06/16 17:32 PHST- 2025/11/19 00:26 [medline] PHST- 2025/06/16 18:25 [pubmed] PHST- 2025/06/16 17:32 [entrez] AID - 10.1080/02701367.2025.2513362 [doi] PST - ppublish SO - Res Q Exerc Sport. 2025 Dec;96(4):812-818. doi: 10.1080/02701367.2025.2513362. Epub 2025 Jun 16. PMID- 40522029 OWN - NLM STAT- MEDLINE DCOM- 20250616 LR - 20250616 IS - 1365-2214 (Electronic) IS - 0305-1862 (Linking) VI - 51 IP - 4 DP - 2025 TI - Feeding Practices Among Portuguese Parents of 5- to 10-Year-Olds: Psychometric Properties of the Comprehensive Feeding Practices Questionnaire. PG - e70116 LID - 10.1111/cch.70116 [doi] AB - BACKGROUND: Parents, as primary caregivers, are responsible for most decisions related to children's lifestyle. One of the key elements in children's lifestyle is parents' feeding practices and given the relevance of these practices for children's weight and health-related outcomes, it is important to have valid and reliable measures available to address them in both research and practice. In the current study, we examined the psychometric properties of the Comprehensive Feeding Practices Questionnaire (CFPQ) in a sample of Portuguese parents of children aged 5-to-10. We evaluated the questionnaire's factor structure, criterion-related validity and test-retest reliability. METHODS: Primary caregivers (N = 507) of children aged 5-to-10 completed the CFPQ and the Physical Activity Parenting Practices questionnaire, and a subset of the participants (n = 125) completed the CFPQ at a second assessment point, 1 month later. RESULTS: The 49-item 12-factor model originally proposed revealed a poor fit to the data. Following empirically and theoretically driven model modifications, we found a good fit to the data in a model comprising 40 items, organized into seven factors (Monitoring, Emotion regulation, Child control, Pressure to eat, Restriction, Healthy family environment and Promote nutrition autonomy). We combined items into new factors depicting food parenting practices that reflect contents for each of the domains of the map of food parenting practices. Criterion-related validity analyses identified that feeding and physical activity parenting practices were positively associated. Internal consistency reliability and test-retest reliability findings suggest that the CFPQ factors were relatively reliable and stable over time. CONCLUSION: Findings suggest that the 40-item version of the CFPQ organized into seven factors is an adequate instrument to evaluate parents' feeding practices among Portuguese parents of children aged 5-to-10. KEY MESSAGES: Parents' feeding practices are important to evaluate children's health-related outcomes The Comprehensive Feeding Practices Questionnaire is a widely used measure The original 12-factor structure was not suitable for parents of children aged 5-to-10 A 7-factor model based on the content map in food parenting practices had the best fit Parents' feeding and physical activity practices seem to be implemented in tandem. CI - (c) 2025 John Wiley & Sons Ltd. FAU - Canario, Ana Catarina AU - Canario AC AUID- ORCID: 0000-0002-4206-2109 AD - Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal. FAU - Silva-Martins, Marco AU - Silva-Martins M AUID- ORCID: 0000-0002-0545-3039 AD - Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal. FAU - Santos, Susana AU - Santos S AUID- ORCID: 0000-0002-4196-061X AD - Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal. FAU - Krasniqi, Lindon AU - Krasniqi L AUID- ORCID: 0000-0001-6202-3521 AD - University of Trento, Trento, Italy. FAU - Campos, Joana AU - Campos J AUID- ORCID: 0000-0001-6577-5155 AD - Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal. FAU - Abreu-Lima, Isabel AU - Abreu-Lima I AUID- ORCID: 0000-0002-6091-5304 AD - Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal. FAU - Cruz, Orlanda AU - Cruz O AUID- ORCID: 0000-0002-3646-5067 AD - Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal. LA - eng GR - PTDC/SAU-NUT/30715/2017/Fundacao para a Ciencia e a Tecnologia/ GR - CEECINST/00134/2021/Fundacao para a Ciencia e a Tecnologia/ GR - UI/BD/150897/2021/Fundacao para a Ciencia e a Tecnologia/ GR - UIDB/00050/2020/Fundacao para a Ciencia e a Tecnologia/ GR - POCI-01-0145-FEDER-030715/Programa Operacional Competitividade e Internacionalizacao (POCI) and Fundo Europeu de Desenvolvimento Regional (FEDER)/ PT - Journal Article PL - England TA - Child Care Health Dev JT - Child: care, health and development JID - 7602632 SB - IM MH - Humans MH - Psychometrics MH - Female MH - Male MH - Portugal MH - Child, Preschool MH - *Feeding Behavior/psychology MH - *Parenting/psychology MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - *Parents/psychology MH - Child MH - Adult MH - Parent-Child Relations MH - Exercise OTO - NOTNLM OT - children's lifestyle behaviour OT - confirmatory factor analysis OT - criterion-related validity OT - parents' feeding practices EDAT- 2025/06/16 12:27 MHDA- 2025/06/16 12:28 CRDT- 2025/06/16 09:35 PHST- 2025/05/28 00:00 [revised] PHST- 2024/09/20 00:00 [received] PHST- 2025/06/01 00:00 [accepted] PHST- 2025/06/16 12:28 [medline] PHST- 2025/06/16 12:27 [pubmed] PHST- 2025/06/16 09:35 [entrez] AID - 10.1111/cch.70116 [doi] PST - ppublish SO - Child Care Health Dev. 2025;51(4):e70116. doi: 10.1111/cch.70116. PMID- 40522009 OWN - NLM STAT- MEDLINE DCOM- 20250616 LR - 20250620 IS - 1526-2359 (Electronic) IS - 1073-2748 (Print) IS - 1073-2748 (Linking) VI - 32 DP - 2025 Jan-Dec TI - Emerging Adults' Consideration of their Future General and Colorectal-Specific Cancer Risk. PG - 10732748251348537 LID - 10.1177/10732748251348537 [doi] LID - 10732748251348537 AB - IntroductionColorectal cancer (CRC) has a lengthy cellular mutation period and early onset (EOCRC) is linked to lifestyle-related factors. Primary prevention approaches earlier in the life course are needed. Emerging adulthood (age 18-25) is a critical stage for shaping health trajectories, and future orientation influences health behavior decisions. Little is known about emerging adults' consideration of future cancer risk (CFC-Cancer), or perceived CRC risk. This study characterizes emerging adult CFC-Cancer, perceived CRC risk, and how they relate to EOCRC lifestyle related factors and cancer prevention behaviors.MethodsWe conducted a cross-sectional survey of college students at a public university. Measures included demographics, stress, family cancer history, and CRC knowledge. Previously validated measures for diet, sedentariness, smoking, alcohol consumption, and stress management assessed adherence with lifestyle prevention guidelines. HPV vaccination and skin checks appraised cancer prevention. Outcomes included perceived CRC risk (0%-100%) and CFC-Cancer adapted scale. Adjusted linear regression models examined CFC-Cancer and perceived CRC risk predictability.ResultsThe sample (N = 282) mean age was 20 years, 77% were female, 40% were White, and 67% had family cancer history. CRC knowledge mu = 14, and current stress was moderate. 18% completed both cancer prevention behaviors, and protective lifestyle behavior scores ranged between 2-15, mu = 8. Perceived CRC risk = 28%, and CFC-Cancer was moderate (mu = 61). CFC-Cancer model included significant predictors of GPA, CRC knowledge, and lifestyle health behavior score, while Perceived CRC Risk model included age and being employed.ConclusionEmerging adults overestimate CRC risk but also have moderate CFC-Cancer. Accurate CRC knowledge provided to this age group may help redirect CRC health trajectories through integration of EOCRC protective lifestyle health behaviors and sustaining them into adulthood. FAU - Wilt, Jackie Knight AU - Wilt JK AUID- ORCID: 0000-0001-6870-5566 AD - Department of Social and Behavioral Sciences, School of Public Health, Virginia Commonwealth University, Richmond, VA, USA. RINGGOLD: 6889 FAU - Thomson, Maria D AU - Thomson MD AD - Department of Social and Behavioral Sciences, School of Public Health, Virginia Commonwealth University, Richmond, VA, USA. RINGGOLD: 6889 LA - eng PT - Journal Article DEP - 20250616 PL - United States TA - Cancer Control JT - Cancer control : journal of the Moffitt Cancer Center JID - 9438457 SB - IM MH - Humans MH - *Colorectal Neoplasms/prevention & control/psychology/epidemiology MH - Female MH - Male MH - Cross-Sectional Studies MH - Young Adult MH - Adult MH - Life Style MH - Health Behavior MH - *Health Knowledge, Attitudes, Practice MH - Adolescent MH - Risk Factors MH - Surveys and Questionnaires MH - Students/psychology PMC - PMC12174806 OTO - NOTNLM OT - colorectal cancer OT - emerging adults OT - perceived risk OT - primary prevention COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/06/16 12:27 MHDA- 2025/06/16 12:28 PMCR- 2025/06/16 CRDT- 2025/06/16 09:34 PHST- 2025/06/16 12:28 [medline] PHST- 2025/06/16 12:27 [pubmed] PHST- 2025/06/16 09:34 [entrez] PHST- 2025/06/16 00:00 [pmc-release] AID - 10.1177_10732748251348537 [pii] AID - 10.1177/10732748251348537 [doi] PST - ppublish SO - Cancer Control. 2025 Jan-Dec;32:10732748251348537. doi: 10.1177/10732748251348537. Epub 2025 Jun 16. PMID- 40520306 OWN - NLM STAT- MEDLINE DCOM- 20250616 LR - 20250617 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Modeling and mapping under-nutrition among under-five children in Ethiopia: a Bayesian spatial analysis. PG - 1553908 LID - 10.3389/fpubh.2025.1553908 [doi] LID - 1553908 AB - Malnutrition remains a critical global challenge, characterized by an imbalance between nutrient requirements and consumption. Under-nutrition, a specific form of malnutrition, results from inadequate intake of essential nutrients and has severe implications for young children, especially in developing countries. This study aims to model under-nutrition cases among children under five in Ethiopia, utilizing Bayesian spatial models to identify effective interventions. Four models were considered: Generalized Linear Model (GLM), Generalized Linear Mixed Models (GLMM), Intrinsic Conditional Autoregressive (ICAR), and Conditional Autoregressive Besag-York-Mollie (CAR BYM) with negative binomial distribution. The rationale for employing multiple models stems from the need to compare performance and accuracy in capturing spatial heterogeneity. The data were obtained from the Ethiopian Demographic and Health Survey 2019. The parameter estimation was carried out using Bayesian Markov Chain Monte Carlo (MCMC) through the brms package in R, which interfaces with Stan for efficient sampling. The models were evaluated based on the Watanabe Akaike Information Criterion (WAIC) and Leave-One-Out (LOO) cross-validation, with CAR BYM emerging as the best-fitting model. Spatial modeling revealed that maternal age, breastfeeding practices, access to clean water and sanitation facilities, cooking practices, maternal education, and wealth status significantly influence the number of under-nutrition cases among children under five in Ethiopia. Specifically, lower maternal education, poorer wealth status, and inadequate access to clean water and sanitation were associated with an increased number of under-nutrition cases, while improved breastfeeding practices, rich wealth status and higher maternal education were associated with decreased number of cases. Regional disparities also played a significant role, with the CAR BYM model effectively identifying high-risk regions such as Somali, Afar, and parts of Oromia, identified as areas requiring targeted intervention. CI - Copyright (c) 2025 Habtewold and Arero. FAU - Habtewold, Fekade Getabil AU - Habtewold FG AD - Department of Mathematics, Kotebe University of Education, Addis Ababa, Ethiopia. FAU - Arero, Butte Gotu AU - Arero BG AD - Department of Statistics, Addis Ababa University, Addis Ababa, Ethiopia. LA - eng PT - Journal Article DEP - 20250530 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Ethiopia/epidemiology MH - Bayes Theorem MH - Child, Preschool MH - Infant MH - *Spatial Analysis MH - Female MH - Male MH - *Malnutrition/epidemiology MH - Adult MH - Socioeconomic Factors PMC - PMC12162586 OTO - NOTNLM OT - Bayesian OT - Besag York Mollie OT - Ethiopia OT - negative binomial distribution OT - spatial analysis OT - under-five children OT - under-nutrition COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/06/16 17:20 MHDA- 2025/06/16 17:21 PMCR- 2025/05/30 CRDT- 2025/06/16 06:39 PHST- 2024/12/31 00:00 [received] PHST- 2025/05/05 00:00 [accepted] PHST- 2025/06/16 17:21 [medline] PHST- 2025/06/16 17:20 [pubmed] PHST- 2025/06/16 06:39 [entrez] PHST- 2025/05/30 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1553908 [doi] PST - epublish SO - Front Public Health. 2025 May 30;13:1553908. doi: 10.3389/fpubh.2025.1553908. eCollection 2025. PMID- 40517756 OWN - NLM STAT- MEDLINE DCOM- 20250720 LR - 20250720 IS - 1424-859X (Electronic) IS - 1424-8581 (Print) IS - 1424-8581 (Linking) VI - 165 IP - 2 DP - 2025 TI - ACAN Repeat Number Polymorphism in Patients with Idiopathic Short Stature. PG - 51-56 LID - 10.1159/000545736 [doi] AB - INTRODUCTION: Idiopathic short stature (ISS) refers to non-syndromic growth failure without chronic disorders. The molecular basis of ISS remains largely unknown. Although a variable number of tandem repeats (VNTR) of 57 nucleotides in ACAN is known to correlate with the height of people in the general population, the role of this genetic variant in the etiology of ISS has not been studied. METHODS: We studied 128 Japanese patients with ISS, including 63 patients with prenatal and postnatal growth failure (small-for-gestational age-SS [SGA-SS]), and 100 control individuals. To examine the repeat numbers of ACAN VNTR, we amplified the VNTR-containing genomic region and analyzed the PCR products by gel electrophoresis. The accuracy of the results was confirmed by long-read next-generation sequencing. RESULTS: The repeat numbers of the patient group were similarly distributed to those of the control group, and no patient had a very small number. Moreover, the repeat numbers of the shorter and longer alleles in each individual, as well as the average number of the two alleles, were comparable between the two groups. The height standard deviation scores obtained from 106 patients did not correlate with the repeat numbers. There was no difference in the repeat numbers between the SGA-SS or non-SGA ISS groups, and the control group. CONCLUSION: The results of this study indicate that reduced repeat numbers of ACAN VNTR do not represent a monogenic cause or a major contributing factor for ISS. Our findings await further validation. CI - (c) 2025 The Author(s). Published by S. Karger AG, Basel. FAU - Nakamura, Sayuri AU - Nakamura S AD - Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan. AD - Center for Postgraduate Education and Training, National Center for Child Health and Development, Tokyo, Japan. AD - Department of Advanced Pediatric Medicine, Tohoku University School of Medicine, Tokyo, Japan. FAU - Kuroki, Yoko AU - Kuroki Y AD - Division of Diversity Research, National Research Institute for Child Health and Development, Tokyo, Japan. AD - Department of Genome Medicine, National Research Institute for Child Health and Development, Tokyo, Japan. AD - Division of Collaborative Research, National Research Institute for Child Health and Development, Tokyo, Japan. FAU - Pak, Kyongsun AU - Pak K AD - Department of Data Science, National Center for Child Health and Development, Tokyo, Japan. FAU - Kamimaki, Tsutomu AU - Kamimaki T AD - Department of Pediatrics, Shizuoka City Shimizu Hospital, Shizuoka, Japan. FAU - Mochizuki, Takahiro AU - Mochizuki T AD - Kibounomori Growth and Development Clinic, Osaka, Japan. FAU - Ishiguro, Akira AU - Ishiguro A AD - Center for Postgraduate Education and Training, National Center for Child Health and Development, Tokyo, Japan. FAU - Fukami, Maki AU - Fukami M AD - Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan. AD - Division of Diversity Research, National Research Institute for Child Health and Development, Tokyo, Japan. LA - eng PT - Journal Article DEP - 20250613 PL - Switzerland TA - Cytogenet Genome Res JT - Cytogenetic and genome research JID - 101142708 RN - 0 (Aggrecans) RN - 0 (ACAN protein, human) SB - IM MH - Humans MH - Female MH - Male MH - *Aggrecans/genetics MH - *Minisatellite Repeats/genetics MH - *Polymorphism, Genetic MH - Child MH - Case-Control Studies MH - Alleles MH - Adolescent MH - *Dwarfism/genetics MH - Body Height/genetics MH - Child, Preschool MH - *Growth Disorders/genetics MH - Infant, Small for Gestational Age MH - Adult PMC - PMC12237279 OTO - NOTNLM OT - Copy number polymorphism OT - Height OT - Repeat OT - Small-for-gestational age OT - Variable number of tandem repeats COIS- M.F. was a member of the Editorial Board of this journal at the time of submission. The other authors declare no conflicts of interest to declare. EDAT- 2025/06/16 00:26 MHDA- 2025/07/21 00:30 PMCR- 2025/06/13 CRDT- 2025/06/15 18:22 PHST- 2025/02/20 00:00 [received] PHST- 2025/04/03 00:00 [accepted] PHST- 2025/07/21 00:30 [medline] PHST- 2025/06/16 00:26 [pubmed] PHST- 2025/06/15 18:22 [entrez] PHST- 2025/06/13 00:00 [pmc-release] AID - 000545736 [pii] AID - 545736 [pii] AID - 10.1159/000545736 [doi] PST - ppublish SO - Cytogenet Genome Res. 2025;165(2):51-56. doi: 10.1159/000545736. Epub 2025 Jun 13. PMID- 40517371 OWN - NLM STAT- MEDLINE DCOM- 20251003 LR - 20260418 IS - 1095-9254 (Electronic) IS - 0140-1971 (Linking) VI - 97 IP - 7 DP - 2025 Oct TI - Psychological Empowerment and Its Associations With Adolescents' Adiposity Risk: A Structural Equation Modeling Approach. PG - 1832-1839 LID - 10.1002/jad.70005 [doi] AB - INTRODUCTION: Psychological empowerment (PE) has been widely studied in the context of adolescent social behavior, yet its application in addressing childhood obesity remains underexplored. This study aims to investigate the relationship between health-related PE and adiposity risk among adolescents. METHODS: A sample of 505 Chinese adolescents aged 12-15 years (Mage = 14.69; 52% male) completed a self-administered questionnaire assessing health-related PE levels, alongside anthropometric measurements to assess adiposity risk. Confirmatory factor analysis (CFA) was conducted to validate the structural validity of the PE construct, and structural equation modeling (SEM) was employed to examine its association with adiposity indicators. RESULTS: The second-order four-factor measurement model of PE demonstrated an acceptable model fit. SEM analysis further revealed a significant negative association between PE and adolescents' adiposity risk as reflected by BMI z-scores, weight-to-height ratios, and body fat percentages (beta = -0.145, p = 0.008). CONCLUSION: Health-related PE is a multi-dimensional construct significantly linked to adolescents' adiposity risk. Enhancing PE levels may serve as a valuable strategy for obesity prevention, aligning with adolescents' psychological and developmental needs. CI - (c) 2025 Foundation for Professionals in Services to Adolescents. FAU - Chen, Yu AU - Chen Y AUID- ORCID: 0009-0000-0924-1992 AD - Department of Child Health and Social Medicine, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China. FAU - Zhang, Youjie AU - Zhang Y AUID- ORCID: 0000-0003-4319-9809 AD - Department of Child Health and Social Medicine, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China. LA - eng GR - This work was supported by the National Natural Science Foundation of China [grant number 82204068]./ PT - Journal Article DEP - 20250615 PL - England TA - J Adolesc JT - Journal of adolescence JID - 7808986 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - Child MH - *Adiposity MH - Latent Class Analysis MH - Surveys and Questionnaires MH - *Pediatric Obesity/psychology MH - Body Mass Index MH - China MH - *Empowerment MH - Factor Analysis, Statistical OTO - NOTNLM OT - adiposity risk OT - adolescents OT - confirmatory factor analysis OT - psychological empowerment OT - structural equation model EDAT- 2025/06/15 16:41 MHDA- 2025/10/03 12:35 CRDT- 2025/06/15 11:22 PHST- 2025/06/03 00:00 [revised] PHST- 2025/03/23 00:00 [received] PHST- 2025/06/04 00:00 [accepted] PHST- 2025/10/03 12:35 [medline] PHST- 2025/06/15 16:41 [pubmed] PHST- 2025/06/15 11:22 [entrez] AID - 10.1002/jad.70005 [doi] PST - ppublish SO - J Adolesc. 2025 Oct;97(7):1832-1839. doi: 10.1002/jad.70005. Epub 2025 Jun 15. PMID- 40516653 OWN - NLM STAT- MEDLINE DCOM- 20250731 LR - 20261008 IS - 1541-6100 (Electronic) IS - 0022-3166 (Print) IS - 0022-3166 (Linking) VI - 155 IP - 8 DP - 2025 Aug TI - Maternal Diet Quality and BMI as Predictors of Human Milk C-Reactive Protein Concentrations. PG - 2582-2590 LID - S0022-3166(25)00360-8 [pii] LID - 10.1016/j.tjnut.2025.06.004 [doi] AB - BACKGROUND: Little is known regarding joint associations of maternal diet quality and adiposity in relation to milk concentrations of inflammatory markers. OBJECTIVES: We evaluated whether maternal diet quality and prepregnancy body mass index (BMI) predict C-reactive protein (CRP) concentration in human milk. METHODS: We used Cincinnati data from Global Exploration of Human Milk study, a prospective cohort of healthy mother-infant dyads (n = 100). We computed a dietary inflammatory index (DII) from diet recalls obtained 4-13 wk postpartum, where higher score indicating a more proinflammatory diet. CRP concentrations in week 4 milk samples were measured after validating a high-sensitivity enzyme-linked immunosorbent assay (ELISA) kit. Participants were categorized into low and high DII groups at the median and BMI groups defined as normal (<25) or elevated (>/=25). The associations of categorical DII score and BMI with milk CRP concentrations were tested using linear regression. Then, we compared milk CRP concentrations across 4 combinations of DII x BMI. RESULTS: Median (Q1, Q3) values were as follows-DII: 0.13 (-1.54, 1.27); BMI: 25.4 (22.8, 30.4); and milk CRP: 101.7 (54.8, 172.3) ng/mL. Across the 4 DII x BMI groups, milk CRP was significantly different (P = 0.009) but there was no significant difference in maternal age, education, or ethnicity. Having BMI >/= 25 was associated with higher milk CRP concentrations than having BMI <25 (beta +/- SE: 96.19 +/- 27.23 ng/mL; P = 0.0006), although the main effect of DII was not statistically significant. The DII x BMI interaction was significant: BMI predicted milk CRP concentrations only when DII was low. Women with low DII and normal BMI had lower CRP concentrations [n = 30; 64.3 (38.2, 121.4) ng/mL] than those in the other 3 groups combined [n = 70; 124.1 (71.2, 181) ng/mL; P = 0.019]. CONCLUSIONS: Diet modifies the relation between maternal BMI and milk CRP. The study of milk cytokines and other bioactive compounds should include measures of diet quality, when feasible, in addition to maternal adiposity. CI - Copyright (c) 2025 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Cetinkaya, Hatice AU - Cetinkaya H AD - Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, United States. FAU - Ollberding, Nicholas J AU - Ollberding NJ AD - Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States. FAU - Summer, Suzanne S AU - Summer SS AD - Bionutrition Core, Schubert Research Clinic, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States. FAU - Meredith, Nathan A AU - Meredith NA AD - Reckitt/Mead Johnson Nutrition Institute, Evansville, IN, United States. FAU - Maria, Sarah D AU - Maria SD AD - Reckitt/Mead Johnson Nutrition Institute, Evansville, IN, United States. FAU - Morrow, Ardythe L AU - Morrow AL AD - Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, United States. FAU - Nommsen-Rivers, Laurie A AU - Nommsen-Rivers LA AD - Department of Nutrition, University of California, Davis, CA, United States. Electronic address: lnrivers@ucdavis.edu. LA - eng GR - R01 HD109915/HD/NICHD NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20250612 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 RN - 9007-41-4 (C-Reactive Protein) SB - IM MH - Humans MH - *C-Reactive Protein/metabolism/analysis MH - Female MH - *Body Mass Index MH - *Milk, Human/chemistry MH - Adult MH - *Diet MH - Prospective Studies MH - *Maternal Nutritional Physiological Phenomena MH - Young Adult PMC - PMC13639618 OTO - NOTNLM OT - BMI OT - C-reactive protein OT - exclusive breastfeeding OT - human milk bioactives OT - inflammation OT - inflammatory compounds OT - maternal dietary inflammatory index COIS- Conflict of interest NAM and SDM are employees of the Reckitt/Mead Johnson Nutrition. ALM reports financial support by Mead Johnson Nutrition. KAD is an employee of Danone Research. The other authors report no conflicts of interest. EDAT- 2025/06/15 04:45 MHDA- 2025/08/01 00:29 PMCR- 2025/06/12 CRDT- 2025/06/14 19:13 PHST- 2025/03/24 00:00 [received] PHST- 2025/05/22 00:00 [revised] PHST- 2025/06/10 00:00 [accepted] PHST- 2025/08/01 00:29 [medline] PHST- 2025/06/15 04:45 [pubmed] PHST- 2025/06/14 19:13 [entrez] PHST- 2025/06/12 00:00 [pmc-release] AID - S0022-3166(25)00360-8 [pii] AID - 10.1016/j.tjnut.2025.06.004 [doi] PST - ppublish SO - J Nutr. 2025 Aug;155(8):2582-2590. doi: 10.1016/j.tjnut.2025.06.004. Epub 2025 Jun 12. PMID- 40515743 OWN - NLM STAT- MEDLINE DCOM- 20250614 LR - 20260924 IS - 1365-2060 (Electronic) IS - 0785-3890 (Print) IS - 0785-3890 (Linking) VI - 57 IP - 1 DP - 2025 Dec TI - Back to the pre-industrial age? FAOSTAT statistics of food supply reveal radical dietary changes accompanied by declining body height, rising obesity rates, and declining phenotypic IQ in affluent Western countries. PG - 2514073 LID - 10.1080/07853890.2025.2514073 [doi] LID - 2514073 AB - Meta-analyses of observational and clinical studies conducted in recent years have raised serious doubts about the validity of the low-fat dietary recommendations introduced in the late 1970s/early 1980s, due to the absence of any convincing link between saturated fat and the risk of cardiovascular diseases. At the same time, long-term food supply statistics from the FAOSTAT database show that these recommendations were at the root of fundamental dietary changes in Western countries, which resulted in a lower consumption of eggs and red meat, a higher consumption of cereals and poultry, a decline in average protein quality and, overall, in a higher glycemic load of the diet. Because current views on human nutrition are based primarily on highly unreliable questionnaire data from observational studies, the purpose of this commentary is to provide an alternative ecological (country-level) perspective and to trace the consequences of these nutritional changes using the FAOSTAT database in combination with available anthropological and health statistics. This comparison shows a close connection between the decline in protein quality and the sudden reversal of the positive height trend in some Western countries, after approximately 150 years of continuous growth, which points to suboptimal levels of child nutrition. The sharp increase in the prevalence of obesity and type 2 diabetes is strongly correlated with the increasing consumption of high-glycemic carbohydrates and sweeteners, and is also interconnected with the decrease in body height, because a high-quality, growth-stimulating diet during adolescence is inversely related to obesity. Given the long-term association between height and phenotypic IQ, the lower quality of nutrients in children's diet may also seriously affect intellectual potential and future civilizational development. In light of these findings, current nutritional strategies should be seriously reconsidered and recommended protein intakes for children must be urgently reevaluated. FAU - Grasgruber, Pavel AU - Grasgruber P AUID- ORCID: 0000-0002-8685-0705 AD - Faculty of Sports Studies, Masaryk University, Brno, Czech Republic. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250614 PL - England TA - Ann Med JT - Annals of medicine JID - 8906388 SB - IM EIN - Ann Med. 2025 Dec;57(1):2535823. doi: 10.1080/07853890.2025.2535823. PMID: 40692200 MH - Humans MH - *Obesity/epidemiology MH - *Diet/trends MH - *Body Height MH - *Food Supply/statistics & numerical data MH - Child MH - Diabetes Mellitus, Type 2/epidemiology MH - Adolescent PMC - PMC12168400 OTO - NOTNLM OT - Child health OT - flynn effect OT - nutrition OT - obesity OT - physical growth COIS- The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/06/14 17:10 MHDA- 2025/06/14 17:11 PMCR- 2025/06/14 CRDT- 2025/06/14 10:23 PHST- 2025/06/14 17:11 [medline] PHST- 2025/06/14 17:10 [pubmed] PHST- 2025/06/14 10:23 [entrez] PHST- 2025/06/14 00:00 [pmc-release] AID - 2514073 [pii] AID - 10.1080/07853890.2025.2514073 [doi] PST - ppublish SO - Ann Med. 2025 Dec;57(1):2514073. doi: 10.1080/07853890.2025.2514073. Epub 2025 Jun 14. PMID- 40514602 OWN - NLM STAT- MEDLINE DCOM- 20250613 LR - 20250713 IS - 1432-1335 (Electronic) IS - 0171-5216 (Print) IS - 0171-5216 (Linking) VI - 151 IP - 6 DP - 2025 Jun 14 TI - Sit to stand is a new reliable method for assessing strength, power, and velocity exercise in adult pediatric cancer survivors. PG - 189 LID - 10.1007/s00432-025-06225-7 [doi] LID - 189 AB - PURPOSE: We aimed to analyze the intra-set reliability of 5 sit-to-stand (5-STS) exercises with a functional electromechanical dynamometer (FEMD) and to determine and compare the load-velocity (L-V) profile in the STS exercise in adult pediatric cancer survivors by sex, age, body mass index, and type and treatment of cancer. METHOD: A total of 47 participants performed the 5-STS test with 5% and 20% body weight (BW) to assess intrasession reliability and analyze differences in L-V profiles by sex, age, BMI, and type and treatment of cancer. RESULTS: Very high and extremely high relative reliability was found for both the 5% STS (ICC = 0.80-0.94) and the 20% STS (ICC = 0.87-0.95) relate to average and peak force, power, and velocity. Regarding L-V profiles, significant differences were only found in relation to sex for the velocity-axis intercept and area under the line (p < 0.05). CONCLUSION: The 5-STS test with a load of 5% and 20% of BW using a FEMD is a reliable method for assessing strength, power, and velocity exercise in adult pediatric cancer survivors. There was a relation to sex for the variables of L-V profile. IMPLICATIONS FOR CANCER SURVIVORS: Reliable assessments of muscular strength, like the 5-STS test using FEMD, offer a safer, less demanding alternative to maximal strength tests (e.g., 1RM), enabling precise intensity control and better-tailored rehabilitation programs. CI - (c) 2025. The Author(s). FAU - Rodriguez-Perea, Angela AU - Rodriguez-Perea A AUID- ORCID: 0000-0001-5155-1337 AD - Faculty of Physical Activity and Sports Sciences, Department of Physical and Sport Education, Universidad de Leon, Leon, Spain. AD - Department of Physical Education and Sport, Faculty of Sports Sciences, University of Granada, Granada, Spain. AD - Strength & Conditioning Laboratory, Department Physical Education and Sports, Faculty of Sport Sciences, CTS-642 Research Group, University of Granada, Granada, Spain. FAU - Jerez-Mayorga, Daniel AU - Jerez-Mayorga D AUID- ORCID: 0000-0002-6878-8004 AD - Department of Physical Education and Sport, Faculty of Sports Sciences, University of Granada, Granada, Spain. AD - Strength & Conditioning Laboratory, Department Physical Education and Sports, Faculty of Sport Sciences, CTS-642 Research Group, University of Granada, Granada, Spain. AD - Exercise and Rehabilitation Sciences Institute, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago, Chile. FAU - Ubago-Guisado, Esther AU - Ubago-Guisado E AUID- ORCID: 0000-0002-9397-2399 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. estherug@ugr.es. AD - Instituto de Investigacion Biosanitaria ibs.Granada, Granada, Spain. estherug@ugr.es. FAU - Marmol-Perez, Andres AU - Marmol-Perez A AUID- ORCID: 0000-0003-1828-4614 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. FAU - Jimenez-Lupion, Daniel AU - Jimenez-Lupion D AUID- ORCID: 0000-0002-6008-909X AD - Department of Physical Education and Sport, Faculty of Sports Sciences, University of Granada, Granada, Spain. AD - Strength & Conditioning Laboratory, Department Physical Education and Sports, Faculty of Sport Sciences, CTS-642 Research Group, University of Granada, Granada, Spain. FAU - Rodriguez-Solana, Andrea AU - Rodriguez-Solana A AUID- ORCID: 0000-0001-7125-4970 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. FAU - Rios, Luis Javier Chirosa AU - Rios LJC AUID- ORCID: 0000-0002-1008-176X AD - Department of Physical Education and Sport, Faculty of Sports Sciences, University of Granada, Granada, Spain. AD - Strength & Conditioning Laboratory, Department Physical Education and Sports, Faculty of Sport Sciences, CTS-642 Research Group, University of Granada, Granada, Spain. FAU - Llorente-Cantarero, Francisco J AU - Llorente-Cantarero FJ AUID- ORCID: 0000-0003-0018-2011 AD - Instituto de Investigacion Biomedica Maimonides (IMIBIC), Cordoba, Spain. AD - CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. AD - Departamento de Didacticas Especificas, Facultad de Ciencias de la Educacion y Psicologia, Universidad de Cordoba, Cordoba, Spain. FAU - Herrada-Robles, Maria AU - Herrada-Robles M AUID- ORCID: 0009-0005-1284-3296 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. FAU - Gracia-Marco, Luis AU - Gracia-Marco L AUID- ORCID: 0000-0002-4020-0256 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. AD - Instituto de Investigacion Biosanitaria ibs.Granada, Granada, Spain. AD - CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. LA - eng PT - Journal Article DEP - 20250614 PL - Germany TA - J Cancer Res Clin Oncol JT - Journal of cancer research and clinical oncology JID - 7902060 SB - IM MH - Humans MH - Male MH - Female MH - *Cancer Survivors MH - Adult MH - *Muscle Strength/physiology MH - *Neoplasms/physiopathology/rehabilitation MH - Young Adult MH - Child MH - Adolescent MH - *Exercise/physiology MH - Reproducibility of Results MH - *Exercise Test/methods PMC - PMC12166015 OTO - NOTNLM OT - Childhood cancer, reproducibility of results, functional electromechanical dynamometer OT - Muscle strength dynamometer OT - Resistance training COIS- Declarations. Ethics approval and consent to participate: The study protocol was approved by the Institutional Review Board of the CEI- Cordoba (ref: 5131) and was conducted in accordance with the Declaration of Helsinki. Consent for publication: All participants completed a written informed consent for publication. Competing interests: The authors declare no competing interests. Consent to participate: All participants were informed of the nature, aims and risks associated with the experimental procedure before giving written consent to participate. EDAT- 2025/06/14 16:45 MHDA- 2025/06/14 16:46 PMCR- 2025/06/14 CRDT- 2025/06/13 23:22 PHST- 2025/04/03 00:00 [received] PHST- 2025/05/05 00:00 [accepted] PHST- 2025/06/14 16:46 [medline] PHST- 2025/06/14 16:45 [pubmed] PHST- 2025/06/13 23:22 [entrez] PHST- 2025/06/14 00:00 [pmc-release] AID - 10.1007/s00432-025-06225-7 [pii] AID - 6225 [pii] AID - 10.1007/s00432-025-06225-7 [doi] PST - epublish SO - J Cancer Res Clin Oncol. 2025 Jun 14;151(6):189. doi: 10.1007/s00432-025-06225-7. PMID- 40513844 OWN - NLM STAT- MEDLINE DCOM- 20260607 LR - 20260608 IS - 1532-8503 (Electronic) IS - 1051-2276 (Linking) VI - 36 IP - 3 DP - 2026 May TI - Development and Validation of a Knowledge, Attitude, and Practice Questionnaire and Its Utility Study Toward Nutritional Habits Among Nondialytic chronic kidney disease Patients: A Prospective Study. PG - 445-453 LID - S1051-2276(25)00124-4 [pii] LID - 10.1053/j.jrn.2025.06.001 [doi] AB - OBJECTIVE: Knowledge, attitude, and practices (KAPs) related to dietary habits play a critical role in managing disease progression in chronic kidney disease (CKD) patients, yet these aspects remain understudied. This study focused on developing, validating, and assessing the utility of a tailored KAP questionnaire specifically designed for CKD patients. METHODS: This prospective study was conducted from November 2022 to November 2023 among CKD stage 3 to nondialytic stage 5 patients attending a nephrology outpatient department. A multiple-choice KAP questionnaire, developed with input from 10 nephrologists, included 33 knowledge items (diet 23, disease 10), 33 attitude items on a Likert scale, and 11 practice items on dietary intake. Validity was assessed in a pilot group of 30 CKD patients. A total of 199 patients aged 18-60 years were enrolled and randomized into three diet groups: normal protein intake (0.8-1.0 g/kg/day), low protein intake (0.6 g/kg/day), and very low protein intake with ketoanalogues supplementation (0.3 g/kg/day). Baseline demographic, socioeconomic, dietary data, and KAP scores were recorded, followed by dietary counseling. KAP scores were reassessed at 6 months and compared to baseline. RESULTS: Among 199 enrolled CKD patients (60% male, 74.7% literate), postcounselling KAP scores showed significant improvements: knowledge increased from 29.5 +/- 21.3 to 53.3 +/- 19.8, attitude from 108.8 +/- 16.2 to 133.9 +/- 20.2, and practice from 17.0 +/- 3.2 to 20.1 +/- 2.8 (P < .05). In addition, all KAP components and estimated glomerular filtration rate significantly improved across different CKD stages following the 6-month dietary intervention. CONCLUSION: The validated KAP questionnaire revealed significant improvements in knowledge, attitude, and practice over 6 months following dietary counseling. These findings underscore the necessity of integrating dietary counseling into the management of CKD at all stages. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Mahapatra, Himansu Sekhar AU - Mahapatra HS AD - Department of Nephrology, ABVIMS & RML Hospital, New Delhi, India. Electronic address: hsmnephro@gmail.com. FAU - Balakrishna, Muthukumar AU - Balakrishna M AD - Department of Nephrology, ABVIMS & RML Hospital, New Delhi, India. FAU - Pursunani, Lalit AU - Pursunani L AD - ABVIMS & RML Hospital, New Delhi, India. FAU - Suman, Beauty AU - Suman B AD - ABVIMS & RML Hospital, New Delhi, India. FAU - Lakshman AU - Lakshman AD - Department of Nephrology, ABVIMS & RML Hospital, New Delhi, India. FAU - Khattar, Deepshikha AU - Khattar D AD - ABVIMS & RML Hospital, New Delhi, India. FAU - Paul, Sheli AU - Paul S AD - ABVIMS & RML Hospital, New Delhi, India. FAU - Krishnan, Chandra AU - Krishnan C AD - Department of Nephrology, ABVIMS & RML Hospital, New Delhi, India. FAU - Arora, Arpita AU - Arora A AD - ABVIMS & RML Hospital, New Delhi, India. FAU - Suri, Nirja AU - Suri N AD - ABVIMS & RML Hospital, New Delhi, India. LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Validation Study DEP - 20250611 PL - United States TA - J Ren Nutr JT - Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation JID - 9112938 SB - IM MH - Humans MH - *Health Knowledge, Attitudes, Practice MH - Prospective Studies MH - Middle Aged MH - Male MH - Adult MH - Female MH - Surveys and Questionnaires/standards MH - *Renal Insufficiency, Chronic/diet therapy/psychology MH - *Feeding Behavior/psychology MH - Adolescent MH - Young Adult MH - Diet, Protein-Restricted MH - Diet MH - Reproducibility of Results OTO - NOTNLM OT - KAP questionnaire OT - attitude OT - chronic kidney disease OT - knowledge OT - nutritional habits OT - practice EDAT- 2025/06/14 16:44 MHDA- 2026/06/07 06:32 CRDT- 2025/06/13 19:17 PHST- 2025/01/23 00:00 [received] PHST- 2025/05/09 00:00 [revised] PHST- 2025/06/03 00:00 [accepted] PHST- 2026/06/07 06:32 [medline] PHST- 2025/06/14 16:44 [pubmed] PHST- 2025/06/13 19:17 [entrez] AID - S1051-2276(25)00124-4 [pii] AID - 10.1053/j.jrn.2025.06.001 [doi] PST - ppublish SO - J Ren Nutr. 2026 May;36(3):445-453. doi: 10.1053/j.jrn.2025.06.001. Epub 2025 Jun 11. PMID- 40513109 OWN - NLM STAT- MEDLINE DCOM- 20251112 LR - 20260910 IS - 2047-4881 (Electronic) IS - 2047-4873 (Linking) VI - 32 IP - 16 DP - 2025 Nov 11 TI - Maternal intake of dietary protein from plant and animal sources and development of pharmacologically treated hypertension within 10 years after pregnancy. PG - 1637-1648 LID - 10.1093/eurjpc/zwaf343 [doi] AB - AIMS: To investigate associations between intake of protein from plant and animal sources and risk of development of pharmacologically treated hypertension (defined as antihypertensive medication usage >90 days after delivery) in a large population of Norwegian mothers followed up to 10 years after delivery. METHODS AND RESULTS: Women in the Norwegian Mother, Father and Child Cohort Study (MoBa) recruited between 2004-2008 were linked to the Norwegian Prescription Database (2004-2013) to ascertain antihypertensive medication usage. Women with hypertension before pregnancy were excluded, leaving 59 967 mothers for analyses. Diet was assessed by a validated semi-quantitative food frequency questionnaire in mid-pregnancy. Cox proportional hazard analyses evaluated HRs and 95% CIs for quintiles of intake in multivariable models. A total of 1480 (2.5%) women developed hypertension within 10 years of follow-up. Intake of protein from dairy, particularly milk/yoghurt, was inversely associated with hypertension (HR for highest vs. lowest milk/yoghurt quintile: 0.76, 95% CI 0.65, 0.89, P-trend < 0.001). Intake of red meat protein was positively associated with hypertension (HR for quintile four vs. quintile one: 1.27, 95% CI 1.07, 1.51, P-trend = 0.010). No significant associations were observed for plant-based protein sources. CONCLUSION: The findings suggest that intake of protein from dairy sources is inversely associated with hypertension, while protein from red meat is positively associated with developing hypertension up to ten years after pregnancy. This study provides novel contributions to the literature by examining the impact of a diverse array of plant and animal protein sources on the risk of hypertension in women. LAY SUMMARY: This study examined the relationship between protein intake from plant and animal sources and the risk of developing hypertension in Norwegian mothers within 10 years after pregnancy.Consumption of protein from dairy products, especially milk and yoghurt, was inversely associated with hypertension.Intake of red meat protein was positively associated with hypertension. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of the European Society of Cardiology. FAU - Oyen, Jannike AU - Oyen J AUID- ORCID: 0000-0002-5590-5136 AD - Department of Seafood, Nutrition, and Environmental State, Institute of Marine Research, Nordnesgaten 50, 5005 Bergen, Norway. AD - Centre for Nutrition, Department of Clinical Medicine, University of Bergen, Haukelandsbakken 15, 5121 Bergen, Norway. FAU - Brantsaeter, Anne Lise AU - Brantsaeter AL AUID- ORCID: 0000-0001-6315-7134 AD - Department of Food Safety, Centre for Sustainable Diets, Division of Climate and Environmental Health, Norwegian Institute of Public Health, Lovisenberggata 8, 0456 Oslo, Norway. FAU - Myrmel, Lene S AU - Myrmel LS AUID- ORCID: 0000-0002-8260-1648 AD - Department of Seafood, Nutrition, and Environmental State, Institute of Marine Research, Nordnesgaten 50, 5005 Bergen, Norway. FAU - Rosendahl-Riise, Hanne AU - Rosendahl-Riise H AUID- ORCID: 0000-0002-1497-416X AD - Centre for Nutrition, Department of Clinical Medicine, University of Bergen, Haukelandsbakken 15, 5121 Bergen, Norway. FAU - Nygard, Ottar AU - Nygard O AUID- ORCID: 0000-0002-4885-1010 AD - Centre for Nutrition, Department of Clinical Medicine, University of Bergen, Haukelandsbakken 15, 5121 Bergen, Norway. AD - Laboratory Medicine and Pathology, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway. AD - Department of Heart Disease, Haukeland University Hospital, Haukelandsveien 22, 5021 Bergen, Norway. FAU - Gerdts, Eva AU - Gerdts E AUID- ORCID: 0000-0003-4109-2311 AD - Department of Heart Disease, Haukeland University Hospital, Haukelandsveien 22, 5021 Bergen, Norway. AD - Center for Research on Cardiac Disease in Women, Department of Clinical Science, University of Bergen, Laboratory Building, Haukelandsbakken, 5009 Bergen, Norway. FAU - Madsen, Lise AU - Madsen L AUID- ORCID: 0000-0003-4468-1947 AD - Department of Seafood, Nutrition, and Environmental State, Institute of Marine Research, Nordnesgaten 50, 5005 Bergen, Norway. AD - Department of Clinical Medicine, University of Bergen, Jonas Lies vei 91B, 5021 Bergen, Norway. FAU - Egeland, Grace M AU - Egeland GM AUID- ORCID: 0000-0003-4475-5440 AD - Department of Health Registry Research and Development, Division of Health Data and Digitalisation, Norwegian Institute of Public Health, Zander Kaaesgate 7, 5015 Bergen, Norway. AD - Department of Global Public Health and Primary Care, University of Bergen, Arstadveien 17, 5018 Bergen, Norway. LA - eng GR - Norwegian Ministry of Health and Care Services/ GR - Ministry of Education and Research/ PT - Journal Article PL - England TA - Eur J Prev Cardiol JT - European journal of preventive cardiology JID - 101564430 RN - 0 (Animal Proteins, Dietary) RN - 0 (Plant Proteins, Dietary) RN - 0 (Antihypertensive Agents) SB - IM MH - Female MH - Humans MH - Pregnancy MH - Norway/epidemiology MH - *Hypertension/epidemiology/drug therapy/physiopathology/diagnosis MH - Adult MH - *Animal Proteins, Dietary/adverse effects/administration & dosage MH - *Plant Proteins, Dietary/adverse effects/administration & dosage MH - Risk Factors MH - *Antihypertensive Agents/therapeutic use MH - Time Factors MH - Risk Assessment MH - Animals MH - *Blood Pressure/drug effects MH - *Maternal Nutritional Physiological Phenomena MH - Prospective Studies MH - Follow-Up Studies OTO - NOTNLM OT - Animal-based protein sources OT - Cardiovascular disease OT - Diet OT - Hypertension OT - Plant-based protein sources OT - The Norwegian Mother, Father and Child Cohort Study COIS- Conflict of interest: none declared. EDAT- 2025/06/13 18:27 MHDA- 2025/11/12 23:29 CRDT- 2025/06/13 17:03 PHST- 2024/11/02 00:00 [received] PHST- 2025/03/12 00:00 [revised] PHST- 2025/05/20 00:00 [accepted] PHST- 2025/11/12 23:29 [medline] PHST- 2025/06/13 18:27 [pubmed] PHST- 2025/06/13 17:03 [entrez] AID - 8162316 [pii] AID - 10.1093/eurjpc/zwaf343 [doi] PST - ppublish SO - Eur J Prev Cardiol. 2025 Nov 11;32(16):1637-1648. doi: 10.1093/eurjpc/zwaf343. PMID- 40508870 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260924 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 13 IP - 11 DP - 2025 May 26 TI - What Shapes Quality of Life in Youth? A Multidimensional Approach from Lifestyle to Residential Context-Cor-School Study. LID - 10.3390/healthcare13111256 [doi] LID - 1256 AB - Background: Health-related quality of life is a key indicator of well-being that integrates physical, emotional, and social dimensions. Identifying its determinants during childhood and adolescence is essential to guide effective health promotion strategies. Objective: To analyze the association between health-related quality of life and demographic, anthropometric, biochemical, lifestyle, and environmental variables in school-aged children and adolescents. Methods: A cross-sectional study was conducted during the 2023-2024 academic year in northeastern Spain. A total of 571 children and adolescents participated in the study (mean age = 11.64 +/- 1.64 years), of whom 254 were girls (44.48%). Health-related quality of life was assessed using the Revised Children's Quality of Life Questionnaire (KINDL-R), a validated instrument for assessing perceived well-being in pediatric populations. Independent variables included waist-to-height ratio, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, adherence to the Mediterranean diet, weekly physical activity, sleep quality, and residential context (i.e., large urban areas, small urban areas, and municipalities). Multiple linear regression analysis was performed to explore the associations. Results: Older age was associated with lower health-related quality of life (beta = -1.07; 95% CI: -1.61 to -0.53; p < 0.001). In contrast, better adherence to the Mediterranean diet (beta = 0.72; 95% CI: 0.09 to 1.37; p = 0.023), better sleep quality (b = -2.48; p < 0.001), and participants living in cities and large urban areas reported compared to those in municipalities were associated with higher HRQoL (p < 0.05), with moderate effect sizes. No significant associations were found for sex, waist-to-height ratio, cholesterol levels, or physical activity. Conclusions: This study highlights the importance of adopting a multidimensional approach to promote health-related quality of life in young populations, addressing dietary habits, sleep quality, and environmental factors within health promotion strategies. FAU - Pano-Rodriguez, Alvaro AU - Pano-Rodriguez A AUID- ORCID: 0000-0002-6816-6571 AD - Faculty of Education, Psychology and Social Work, Department of Specific Didactics, University of Lleida, 25001 Lleida, Spain. AD - Human Movement Research Group (RGHM), University of Lleida, Placa de Victor Siurana, 25003 Lleida, Spain. FAU - Aixa-Requena, Saul AU - Aixa-Requena S AUID- ORCID: 0009-0007-2034-4600 AD - Faculty of Education, Psychology and Social Work, Department of Specific Didactics, University of Lleida, 25001 Lleida, Spain. AD - Human Movement Research Group (RGHM), University of Lleida, Placa de Victor Siurana, 25003 Lleida, Spain. FAU - Beltran-Garrido, Jose Vicente AU - Beltran-Garrido JV AUID- ORCID: 0000-0001-9286-8453 AD - Physical Exercise and Performance Research Group, Universidad Cardenal Herrera-CEU, CEU Universities, 12006 Castellon de la Plana, Spain. AD - Department of Education Science, School of Humanities and Communication Sciences, Universidad Cardenal Herrera-CEU, CEU Universities, 12006 Castellon de la Plana, Spain. FAU - Batalla-Gavalda, Abraham AU - Batalla-Gavalda A AUID- ORCID: 0000-0003-4337-8890 AD - University School of Health and Sport (EUSES), Universitat Rovira i Virgili, 43870 Amposta, Spain. AD - Department of Education and Specific Didactics, Faculty of Humanities and Social Sciences, Universitat Jaume I, 12071 Castellon de la Plana, Spain. FAU - Hernandez-Gonzalez, Vicenc AU - Hernandez-Gonzalez V AUID- ORCID: 0000-0003-3201-3298 AD - Faculty of Education, Psychology and Social Work, Department of Specific Didactics, University of Lleida, 25001 Lleida, Spain. AD - Human Movement Research Group (RGHM), University of Lleida, Placa de Victor Siurana, 25003 Lleida, Spain. FAU - Conesa-Milian, Enric AU - Conesa-Milian E AUID- ORCID: 0009-0000-1435-1598 AD - Faculty of Education, Psychology and Social Work, Department of Specific Didactics, University of Lleida, 25001 Lleida, Spain. AD - Human Movement Research Group (RGHM), University of Lleida, Placa de Victor Siurana, 25003 Lleida, Spain. FAU - Lopez-Laval, Isaac AU - Lopez-Laval I AUID- ORCID: 0000-0002-9304-3709 AD - Faculty of Health and Sport Science, Department of Physiatry and Nursing, University of Zaragoza, 22071 Huesca, Spain. FAU - Reverter-Masia, Joaquin AU - Reverter-Masia J AUID- ORCID: 0000-0002-9441-2764 AD - Faculty of Education, Psychology and Social Work, Department of Specific Didactics, University of Lleida, 25001 Lleida, Spain. AD - Human Movement Research Group (RGHM), University of Lleida, Placa de Victor Siurana, 25003 Lleida, Spain. LA - eng GR - PID2020-117932RB-I00/State Program for Research, Development, and Innovation Ori-ented to the Challenges of Society, within the framework of the State Plan for R+D+I 2020-2024/ GR - 021 SGR 01619/Generalitat de Catalunya/ GR - Projec.ESCA/Fundacio Catalana per a l'Esport/ PT - Journal Article DEP - 20250526 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12154305 OTO - NOTNLM OT - Mediterranean diet OT - cardiometabolic health OT - children and adolescents OT - health-related quality of life OT - physical activity OT - sleep quality OT - urban-rural differences COIS- The authors declare no conflicts of interest. EDAT- 2025/06/13 06:35 MHDA- 2025/06/13 06:36 PMCR- 2025/05/26 CRDT- 2025/06/13 01:11 PHST- 2025/04/15 00:00 [received] PHST- 2025/05/10 00:00 [revised] PHST- 2025/05/23 00:00 [accepted] PHST- 2025/06/13 06:36 [medline] PHST- 2025/06/13 06:35 [pubmed] PHST- 2025/06/13 01:11 [entrez] PHST- 2025/05/26 00:00 [pmc-release] AID - healthcare13111256 [pii] AID - healthcare-13-01256 [pii] AID - 10.3390/healthcare13111256 [doi] PST - epublish SO - Healthcare (Basel). 2025 May 26;13(11):1256. doi: 10.3390/healthcare13111256. PMID- 40507757 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250615 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 14 IP - 11 DP - 2025 Jun 5 TI - Corporal Composition and Gut Microbiome Modification Through Exclusion Dietary Intervention in Adult Patients with Crohn's Disease: Protocol for a Prospective, Interventional, Controlled, Randomized Clinical Trial. LID - 10.3390/jcm14113998 [doi] LID - 3998 AB - Background: Crohn's disease (CD) is an inflammatory bowel disease in which there is an alteration in the homeostasis and functionality of the intestinal mucosa accompanied by a dysbiosis of the commensal microbiota. The analysis of different dietary strategies to achieve CD remission and reduce gastrointestinal symptoms concludes that it is necessary to restrict the intake of ultra-processed products and to promote the consumption of those with anti-inflammatory effects that improve intestinal permeability and dysbiosis. Methods: Based on previous studies conducted in other cohorts, mainly pediatric, we propose an experimental, prospective, randomized study in patients with active CD who do not show improvement with conventional pharmacological treatment. The control group will receive standard nutritional recommendations while the intervention group will be prescribed an exclusion diet supplemented with enteral nutrition. Results: Patients in the intervention group are expected to exhibit increased lean body mass and reduced visceral fat, as measured by bioelectrical impedance analysis (BIA), alongside higher rates of clinical remission (CDAI), decreased inflammatory markers, and improved gut microbiota composition. Additionally, improvements in health-related quality of life are anticipated, as assessed by validated questionnaires. Conclusions: In the present project, we plan to conduct a detailed study to determine the potential of the exclusion diet for the treatment and remission of CD in adult patients, with the hypothesis that this nutritional intervention will be able to modify and improve intestinal dysbiosis, inflammatory status, and clinical and body composition markers in these patients. FAU - Cano-Marmol, Rosario Paloma AU - Cano-Marmol RP AUID- ORCID: 0000-0003-2098-7626 AD - Department of Endocrinology and Nutrition, Virgen de la Arrixaca University Clinical Hospital, 30120 Murcia, Spain. AD - Obesity, Diabetes and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain. FAU - Fernandez-Ruiz, Virginia Esperanza AU - Fernandez-Ruiz VE AD - Department of Endocrinology and Nutrition, Virgen de la Arrixaca University Clinical Hospital, 30120 Murcia, Spain. AD - Obesity, Diabetes and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain. FAU - Martinez-Pascual, Cristina AU - Martinez-Pascual C AD - Department of Digestive Diseases, Virgen de la Arrixaca University Clinical Hospital, 30120 Murcia, Spain. FAU - Ros-Madrid, Inmaculada AU - Ros-Madrid I AUID- ORCID: 0000-0001-6862-1012 AD - Department of Endocrinology and Nutrition, Virgen de la Arrixaca University Clinical Hospital, 30120 Murcia, Spain. AD - Obesity, Diabetes and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain. FAU - Martin-Pozuelo, Gala AU - Martin-Pozuelo G AD - Department of Endocrinology and Nutrition, Virgen de la Arrixaca University Clinical Hospital, 30120 Murcia, Spain. AD - Obesity, Diabetes and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain. FAU - Oliva-Bolarin, Alba AU - Oliva-Bolarin A AD - Department of Endocrinology and Nutrition, Virgen de la Arrixaca University Clinical Hospital, 30120 Murcia, Spain. AD - Obesity, Diabetes and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain. FAU - Martinez-Sanchez, Maria Antonia AU - Martinez-Sanchez MA AUID- ORCID: 0000-0001-9750-4237 AD - Department of Endocrinology and Nutrition, Virgen de la Arrixaca University Clinical Hospital, 30120 Murcia, Spain. AD - Obesity, Diabetes and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain. FAU - Egea-Valenzuela, Juan AU - Egea-Valenzuela J AD - Department of Digestive Diseases, Virgen de la Arrixaca University Clinical Hospital, 30120 Murcia, Spain. FAU - Nunez-Sanchez, Maria Angeles AU - Nunez-Sanchez MA AUID- ORCID: 0000-0002-8938-2767 AD - Department of Endocrinology and Nutrition, Virgen de la Arrixaca University Clinical Hospital, 30120 Murcia, Spain. AD - Obesity, Diabetes and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain. FAU - Ramos-Molina, Bruno AU - Ramos-Molina B AUID- ORCID: 0000-0001-6804-5449 AD - Department of Endocrinology and Nutrition, Virgen de la Arrixaca University Clinical Hospital, 30120 Murcia, Spain. AD - Obesity, Diabetes and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain. FAU - Ruiz-Alcaraz, Antonio Jose AU - Ruiz-Alcaraz AJ AUID- ORCID: 0000-0001-6913-0610 AD - Department of Biochemistry, Molecular Biology B and Immunology, Faculty of Medicine, University of Murcia, 30120 Murcia, Spain. FAU - Ferrer-Gomez, Mercedes AU - Ferrer-Gomez M AUID- ORCID: 0000-0003-4617-0219 AD - Department of Endocrinology and Nutrition, Virgen de la Arrixaca University Clinical Hospital, 30120 Murcia, Spain. AD - Obesity, Diabetes and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain. LA - eng PT - Journal Article DEP - 20250605 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC12156257 OTO - NOTNLM OT - Crohn's disease OT - corporal composition OT - exclusion diet OT - gut microbiome COIS- The authors declare no conflicts of interest. The funders had no role in the design of this study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2025/06/13 06:35 MHDA- 2025/06/13 06:36 PMCR- 2025/06/05 CRDT- 2025/06/13 01:05 PHST- 2025/03/06 00:00 [received] PHST- 2025/05/13 00:00 [revised] PHST- 2025/05/19 00:00 [accepted] PHST- 2025/06/13 06:36 [medline] PHST- 2025/06/13 06:35 [pubmed] PHST- 2025/06/13 01:05 [entrez] PHST- 2025/06/05 00:00 [pmc-release] AID - jcm14113998 [pii] AID - jcm-14-03998 [pii] AID - 10.3390/jcm14113998 [doi] PST - epublish SO - J Clin Med. 2025 Jun 5;14(11):3998. doi: 10.3390/jcm14113998. PMID- 40507190 OWN - NLM STAT- MEDLINE DCOM- 20250613 LR - 20250615 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 11 DP - 2025 Jun 3 TI - Nutritional Challenges Among Children Under Five in Limpopo Province, South Africa: Complementary Feeding Practices and Dietary Diversity Deficits. LID - 10.3390/nu17111919 [doi] LID - 1919 AB - Objective: The aim of this study was to assess complementary feeding practices and dietary diversity in relation to the nutritional status of children under five attending health facilities in the Thabazimbi sub-district, Limpopo Province. Methods: A cross-sectional study was conducted among 409 mother-child pairs. Data on socio-demographics, feeding practices, and anthropometry were collected using validated tools. Nutritional status was assessed using WHO growth standards, and dietary diversity was evaluated using WHO infant and young child feeding (IYCF) indicators and a 24 h dietary recall. Associations were analyzed using prevalence ratios in STATA 18. Results: Among 409 children (median age: 18 months, IQR: 12-24), 38% were stunted, 13% were underweight, 5% were thin, and 17% were overweight/obese. Exclusive breastfeeding was reported in 27%, and only 24% met the minimum dietary diversity (DDS >/= 4). Complementary feeding practices varied significantly by maternal age, with mixed feeding more common among older mothers and younger mothers more likely to receive feeding advice (p = 0.001). Stunting was associated with being a boy (PR = 1.27; 95% CI: 1.00-1.61), age > 24 months (PR = 0.33; 95% CI: 0.16-0.65), and DDS >/= 4 (PR = 0.72; 95% CI: 0.52-0.99). Underweight was more prevalent among boys (PR = 2.40; 95% CI: 1.40-4.11), but less likely in children with DDS >/= 4 (PR = 0.43; 95% CI: 0.20-0.92) and those from spouse-headed households (PR = 0.33; 95% CI: 0.13-0.87). Thinness was associated with DDS >/= 4 (PR = 2.70; 95% CI: 1.13-6.45) and age 12-24 months (PR = 2.80; 95% CI: 1.02-7.64). Overweight/obesity was linked to age 12-24 months (PR = 1.94; 95% CI: 1.25-3.03) and household income > ZAR 15,000 (PR = 4.09; 95% CI: 2.33-7.17). Conclusions: Complementary feeding and dietary diversity deficits contribute significantly to the dual burden of malnutrition in rural Limpopo, highlighting the need for targeted, context-specific nutrition interventions. FAU - Mafhungo, Tshilidzi AU - Mafhungo T AD - Department of Public Health, School of Health Care Sciences, Sefako Makgatho Health Sciences University, 1 Molotlegi Street, Ga-Rankuwa 0208, South Africa. FAU - Cele, Lindiwe Priscilla AU - Cele LP AUID- ORCID: 0000-0003-2148-7439 AD - Department of Public Health, School of Health Care Sciences, Sefako Makgatho Health Sciences University, 1 Molotlegi Street, Ga-Rankuwa 0208, South Africa. FAU - Mathibe, Mmampedi AU - Mathibe M AD - Department of Public Health, School of Health Care Sciences, Sefako Makgatho Health Sciences University, 1 Molotlegi Street, Ga-Rankuwa 0208, South Africa. FAU - Modjadji, Perpetua AU - Modjadji P AUID- ORCID: 0000-0002-8339-9875 AD - Department of Public Health, School of Health Care Sciences, Sefako Makgatho Health Sciences University, 1 Molotlegi Street, Ga-Rankuwa 0208, South Africa. AD - Non-Communicable Diseases Research Unit, South African Medical Research Council, Tygerberg, Cape Town 7505, South Africa. AD - Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, Florida Campus, Johannesburg 1709, South Africa. LA - eng PT - Journal Article DEP - 20250603 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Infant MH - Male MH - Female MH - Cross-Sectional Studies MH - *Infant Nutritional Physiological Phenomena MH - Child, Preschool MH - *Nutritional Status MH - South Africa/epidemiology MH - *Diet MH - Breast Feeding/statistics & numerical data MH - Growth Disorders/epidemiology MH - Thinness/epidemiology MH - Prevalence MH - Adult MH - *Feeding Behavior PMC - PMC12157810 OTO - NOTNLM OT - South Africa OT - child OT - complementary feeding OT - dietary diversity OT - nutritional status OT - rural population COIS- The authors declare no conflicts of interest. EDAT- 2025/06/13 06:34 MHDA- 2025/06/13 06:35 PMCR- 2025/06/03 CRDT- 2025/06/13 01:02 PHST- 2025/05/14 00:00 [received] PHST- 2025/05/29 00:00 [revised] PHST- 2025/05/30 00:00 [accepted] PHST- 2025/06/13 06:35 [medline] PHST- 2025/06/13 06:34 [pubmed] PHST- 2025/06/13 01:02 [entrez] PHST- 2025/06/03 00:00 [pmc-release] AID - nu17111919 [pii] AID - nutrients-17-01919 [pii] AID - 10.3390/nu17111919 [doi] PST - epublish SO - Nutrients. 2025 Jun 3;17(11):1919. doi: 10.3390/nu17111919. PMID- 40507189 OWN - NLM STAT- MEDLINE DCOM- 20250613 LR - 20250615 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 11 DP - 2025 Jun 3 TI - Health Consciousness, Sensory Appeal, and Perception of Front-of-Package Food Labels as Predictors of Purchase Intention for Unhealthy Foods in Peruvian University Students. LID - 10.3390/nu17111921 [doi] LID - 1921 AB - Background: Health consciousness refers to an individual's level of knowledge and concern regarding the impact of food on personal health; sensory appeal to the influence of attributes such as taste, aroma, appearance, and texture on food preference; and perception of front-of-package (FOP) labels refers to how the presentation of nutritional information on the package affects product choice. Given the increasing concerns about unhealthy food consumption among university students and the role of FOP labels in guiding food choices, it is essential to understand how these factors influence purchase intentions. Objective: This study was to examine the relationship between health consciousness, sensory appeal, and perception of FOP labels with purchase intentions for unhealthy foods in university students. Methods: A cross-sectional predictive study involved 361 students from public and private universities using a non-probability purpose-sampling approach. Data were collected through a previously validated questionnaire and analyzed using multiple linear regression. Results: The results revealed a significant positive association between sensory appeal and purchase intentions for unhealthy foods (beta = 0.339; p < 0.001). In contrast, health consciousness (beta = -0.296; p < 0.001) and perception of FOP labels (beta = -0.237; p < 0.001) were inversely related to purchase intentions. Conclusion: These findings suggest that promoting health consciousness, improving perceptions of FOP labels, and addressing sensory appeal could effectively encourage healthier eating habits and prevent diet-related diseases among university students. FAU - Saintila, Jacksaint AU - Saintila J AUID- ORCID: 0000-0002-7340-7974 AD - Research Group for Nutrition and Healthy Behaviors, Universidad Senor de Sipan, Lambayeque 14001, Peru. FAU - Florian-Castro, Rafael Orlando AU - Florian-Castro RO AUID- ORCID: 0000-0002-7375-0270 AD - Escuela de Posgrado, Universidad San Ignacio de Loyola, Lima 15024, Peru. FAU - Macedo-Barrera, Eufemio Magno AU - Macedo-Barrera EM AD - Facultad de Bromatologia y Nutricion, Universidad Nacional Jose Faustino Sanchez Carrion, Huacho 15135, Peru. FAU - Perez-Facundo, Raquel Patricia AU - Perez-Facundo RP AD - Area de Diseno y Desarrollo, Bakels Peru SAC, Lima 150103, Peru. FAU - Calizaya-Milla, Yaquelin E AU - Calizaya-Milla YE AUID- ORCID: 0000-0002-0170-6131 AD - Research Group for Nutrition and Lifestyle, Universidad Peruana Union, Lima 15464, Peru. LA - eng PT - Journal Article DEP - 20250603 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Food Labeling MH - Male MH - *Students/psychology MH - Female MH - Universities MH - Cross-Sectional Studies MH - Young Adult MH - *Food Preferences/psychology MH - *Intention MH - *Consumer Behavior MH - Peru MH - Adult MH - Adolescent MH - *Health Knowledge, Attitudes, Practice MH - Surveys and Questionnaires MH - Choice Behavior MH - Perception PMC - PMC12156990 OTO - NOTNLM OT - Peru OT - consumer behavior OT - convenience food OT - feeding behavior OT - food preferences OT - nutritional labeling OT - university students COIS- The authors declare no conflicts of interest. EDAT- 2025/06/13 06:34 MHDA- 2025/06/13 06:35 PMCR- 2025/06/03 CRDT- 2025/06/13 01:02 PHST- 2025/05/02 00:00 [received] PHST- 2025/05/30 00:00 [revised] PHST- 2025/05/31 00:00 [accepted] PHST- 2025/06/13 06:35 [medline] PHST- 2025/06/13 06:34 [pubmed] PHST- 2025/06/13 01:02 [entrez] PHST- 2025/06/03 00:00 [pmc-release] AID - nu17111921 [pii] AID - nutrients-17-01921 [pii] AID - 10.3390/nu17111921 [doi] PST - epublish SO - Nutrients. 2025 Jun 3;17(11):1921. doi: 10.3390/nu17111921. PMID- 40507148 OWN - NLM STAT- MEDLINE DCOM- 20250613 LR - 20250615 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 11 DP - 2025 May 30 TI - Integrating Metabolomics and Gut Microbiota to Identify Key Biomarkers and Regulatory Pathways Underlying Metabolic Heterogeneity in Childhood Obesity. LID - 10.3390/nu17111876 [doi] LID - 1876 AB - BACKGROUND/OBJECTIVES: Individuals with childhood obesity exhibit significant metabolic heterogeneity, necessitating precise biomarkers for risk stratification and assessment. This multi-omics investigation characterizes metabolic and microbial signatures underlying divergent metabolic phenotypes in the context of pediatric obesity. METHODS: We analyzed 285 Chinese children (5-7 years) stratified into five groups: wasting (WAS, n = 55), metabolically healthy/unhealthy and normal weight (MHWH, n = 54; MUWH, n = 67), and metabolically healthy/unhealthy obesity (MHO, n = 36; MUO, n = 73). Untargeted metabolomics (Orbitrap ID-X Tribrid) and 16S rRNA sequencing were integrated with multivariate analyses (OPLS-DA with VIP > 1, FDR < 0.05; Maaslin 2 with TSS normalization and BH correction, FDR < 0.10). RESULTS: Analysis identified 225 differential metabolites and 12 bacterial genera. The proportion of steroids and their derivatives among differential metabolites in the MUO/MHO group was significantly lower than that in the OVOB/NOR and OVOB/WAS groups (2.12% vs. 7.9-14.1%). MUO displayed elevated C17 sphinganine and LysoPC (O-18:0) levels but reduced PI (16:0/14:1) levels. In contrast, OVOB showed upregulated glycerol phospholipids (LPCs and PSs) and downregulated PE species (e.g., PE(16:0/16:0)) as well as gut microbiota dysbiosis characterized by a higher Firmicutes/Bacteroidetes (F/B) ratio (2.07 vs. 1.24 in controls, p = 0.009) and reduced alpha diversity (Ace index, Chao1 index, and Shannon index values were lower in the OVOB group, Shannon index: 2.96 vs. 3.45, p = 0.03). SCFA-producing genera were negatively correlated with the OVOB group, while positively associated with PE(16:0/16:0). Internal validation showed differential metabolites had potential predictive efficacy for MUO/MHO (AUC = 0.967) and OVOB/NOR (AUC = 0.888). CONCLUSIONS: We identified distinct lipid disruptions characterizing obesity subtypes, including steroid/terpene deficits and sphingolipid/ether lipid dysregulation in the MUO/MHO groups as well as phospholipid imbalance ( upward arrowLPC/PS downward arrowPE) in the OVOB/NOR groups. The gut microbiota exhibited a profile characterized by low diversity, an increased F/B ratio, and a reduced abundance of SCFA-producing genera. These findings suggest potential biomarkers for childhood obesity stratification, though further validation is warranted. FAU - Xia, Zhiwei AU - Xia Z AUID- ORCID: 0000-0001-6909-8323 AD - NHC Key Laboratory of Public Nutrition and Health, National Institute of Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. AD - Department of School Health, Beijing Center for Disease Control and Prevention, Beijing 100013, China. FAU - Li, Yan AU - Li Y AD - NHC Key Laboratory of Public Nutrition and Health, National Institute of Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Yin, Jiyong AU - Yin J AD - NHC Key Laboratory of Public Nutrition and Health, National Institute of Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Gong, Zhaolong AU - Gong Z AD - NHC Key Laboratory of Public Nutrition and Health, National Institute of Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Sun, Jing AU - Sun J AD - NHC Key Laboratory of Public Nutrition and Health, National Institute of Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Shen, Shi AU - Shen S AUID- ORCID: 0000-0002-9130-3984 AD - NHC Key Laboratory of Public Nutrition and Health, National Institute of Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Yang, Yi AU - Yang Y AUID- ORCID: 0000-0003-1160-3627 AD - Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Control and Prevention, Beijing 100013, China. FAU - Liu, Tingting AU - Liu T AD - NHC Key Laboratory of Public Nutrition and Health, National Institute of Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Wang, Liyuan AU - Wang L AD - NHC Key Laboratory of Public Nutrition and Health, National Institute of Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Huo, Junsheng AU - Huo J AUID- ORCID: 0000-0002-9643-1897 AD - NHC Key Laboratory of Public Nutrition and Health, National Institute of Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. LA - eng GR - Grant No. 102393220020070000012/the Public Health Emergency Project Nutrition Health and Healthy Diet Campaign/ PT - Journal Article DEP - 20250530 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) RN - 0 (RNA, Ribosomal, 16S) SB - IM MH - Humans MH - *Gastrointestinal Microbiome/physiology MH - *Pediatric Obesity/metabolism/microbiology MH - Child MH - Biomarkers/metabolism MH - Child, Preschool MH - Male MH - *Metabolomics/methods MH - Female MH - China MH - RNA, Ribosomal, 16S/genetics PMC - PMC12158115 OTO - NOTNLM OT - childhood obesity OT - gut microbiota OT - metabolic heterogeneity OT - metabolomics OT - multi-omics COIS- The authors declare no conflicts of interest. EDAT- 2025/06/13 06:34 MHDA- 2025/06/13 06:35 PMCR- 2025/05/30 CRDT- 2025/06/13 01:01 PHST- 2025/04/14 00:00 [received] PHST- 2025/05/21 00:00 [revised] PHST- 2025/05/24 00:00 [accepted] PHST- 2025/06/13 06:35 [medline] PHST- 2025/06/13 06:34 [pubmed] PHST- 2025/06/13 01:01 [entrez] PHST- 2025/05/30 00:00 [pmc-release] AID - nu17111876 [pii] AID - nutrients-17-01876 [pii] AID - 10.3390/nu17111876 [doi] PST - epublish SO - Nutrients. 2025 May 30;17(11):1876. doi: 10.3390/nu17111876. PMID- 40507092 OWN - NLM STAT- MEDLINE DCOM- 20250613 LR - 20250615 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 11 DP - 2025 May 27 TI - Relative Validity of the Food Recording Smartphone App Libro in Young People Vulnerable to Eating Disorder: A Preliminary Cross-Over Study. LID - 10.3390/nu17111823 [doi] LID - 1823 AB - Background: Dietary intake plays a crucial role in health research, yet existing methods for its measurement can lead to participant burden, lengthy recording, and human errors, and do not account for age-specific variations. Libro is a real-time diet-tracking mobile-based app offering flexible features. An automated food recording program within Libro was customized for young people vulnerable to eating misbehaviour. This preliminary study assessed its relative validity using a self-administered 24 h recall method as the reference method. Methods: The relative validity of Libro was tested by adopting a cross-over design that recorded food intake over a period of 3 non-consecutive weekdays and 1 weekend day with both methods. The participants were recruited online through a mental health research charity, and this study was conducted fully online. The primary outcome was the concordance of total energy intake between the two methods, with secondary outcomes focusing on the intake of protein, carbohydrates, fats, free sugars, fibre, and trans-fatty acids. Test-retest validity was assessed per method with the intraclass correlation coefficient; a Bland-Altman plot and t-test were performed to test agreement at the group level; correlation coefficient and cross-classification were performed to assess agreement at the individual level. Results: Forty-seven participants were included in the final analysis. The average intraclass correlation coefficient for energy intake measured by Libro over four days was 0.85 (95% CI: 0.76-0.91). Compared to Intake24, the average energy intake recorded using Libro was significantly lower (mean difference: -554 Kcal, 95% CI: -804.1 to -305.6 Kcal, p < 0.001), potentially driven by the reduced reporting of foods rich in free sugars. The correlation coefficient for average energy intake measured by Libro vs. Intake24 was 0.32 (95% CI: 0.03, 0.55), with only 27.7% of subjects classified in the same quartile with both methods (kappa = 0.31, 95% CI: -0.03, 0.55). Concordance varied across specific dietary component measures. Conclusions: While Libro had good test-retest reliability if adopting a multiple administration method, it underreported energy and other aspects of dietary intake, along with poor classification performance compared to Intake24 in a population vulnerable to eating misbehaviour. We suggest that future studies improve user experience to increase compliance and data accuracy. FAU - Basso, Melissa AU - Basso M AD - School of Psychology, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK. AD - School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK. FAU - Zhang, Liangzi AU - Zhang L AUID- ORCID: 0000-0002-6231-5783 AD - Food and Nutrition National Bioscience Research Infrastructure, Quadram Institute Bioscience, Norwich Research Park, Rosalind Franklin Rd., Norwich NR4 7UQ, UK. FAU - Savva, George M AU - Savva GM AUID- ORCID: 0000-0001-9190-124X AD - Core Science Resources, Quadram Institute Bioscience, Norwich Research Park, Rosalind Franklin Rd., Norwich NR4 7UQ, UK. FAU - Cohen Kadosh, Kathrin AU - Cohen Kadosh K AD - School of Psychology, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK. FAU - Traka, Maria H AU - Traka MH AUID- ORCID: 0000-0002-6592-5691 AD - Food and Nutrition National Bioscience Research Infrastructure, Quadram Institute Bioscience, Norwich Research Park, Rosalind Franklin Rd., Norwich NR4 7UQ, UK. LA - eng GR - BB/CCG2260/1 BBS/E/QU/23NB0006/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom GR - na/Faculty of Health and Medical Sciences, University of Surrey/ PT - Journal Article PT - Validation Study DEP - 20250527 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Mobile Applications MH - Male MH - Female MH - Cross-Over Studies MH - Reproducibility of Results MH - Young Adult MH - *Smartphone MH - *Diet Records MH - Energy Intake MH - Adolescent MH - *Feeding and Eating Disorders MH - Adult MH - Diet MH - Eating MH - Feeding Behavior PMC - PMC12157823 OTO - NOTNLM OT - dietary assessment OT - dietary intake OT - eating disorders OT - food recording OT - nutrition OT - young people COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest. EDAT- 2025/06/13 06:34 MHDA- 2025/06/13 06:35 PMCR- 2025/05/27 CRDT- 2025/06/13 01:01 PHST- 2025/04/28 00:00 [received] PHST- 2025/05/15 00:00 [revised] PHST- 2025/05/23 00:00 [accepted] PHST- 2025/06/13 06:35 [medline] PHST- 2025/06/13 06:34 [pubmed] PHST- 2025/06/13 01:01 [entrez] PHST- 2025/05/27 00:00 [pmc-release] AID - nu17111823 [pii] AID - nutrients-17-01823 [pii] AID - 10.3390/nu17111823 [doi] PST - epublish SO - Nutrients. 2025 May 27;17(11):1823. doi: 10.3390/nu17111823. PMID- 40507065 OWN - NLM STAT- MEDLINE DCOM- 20250613 LR - 20260924 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 11 DP - 2025 May 26 TI - Hungarian Adaptation and Validation of the Short Food Literacy Questionnaire (SFLQ-HU). LID - 10.3390/nu17111796 [doi] LID - 1796 AB - BACKGROUND: Food literacy (FL) plays a crucial role in promoting healthy eating and sustainable food choices. The Short Food Literacy Questionnaire (SFLQ) has been widely used to assess FL in different populations. OBJECTIVE: This study aimed to adapt and validate the SFLQ in Hungarian (SFLQ-HU) and evaluate its psychometric properties among university students. METHODS: The adaptation followed international guidelines, including forward- and back-translation, pre-testing, and confirmatory factor analysis (CFA). Reliability was assessed using Cronbach's alpha, while criterion validity was tested through correlations with other health-related scales. For statistical analysis, IBM AMOS 26.0 and SPSS 28.0 software were used. RESULTS: The survey involved 1325 (n = 1325) young adults in 2024. Overall, 76% of the sample were women (n = 1007), and 77.43% of the sample were under 25 years old (n = 1025). The FL level scored 36.47 points (SD: 7.53), with the highest score being 52 and the lowest score being 14.8. The SFLQ-HU demonstrated excellent internal consistency (Cronbach's alpha = 0.850) and a good fit for the one-factor structure in CFA. Test-retest reliability confirmed the stability of the instrument. Significant correlations were found between the SFLQ-HU and measures of health literacy (r = 0.197; p < 0.001), food choice motivations (r = 0.394; p < 0.001), and barriers to health behaviors (r = 0.353; p < 0.001). CONCLUSIONS: The SFLQ-HU is a reliable and valid tool for assessing food literacy of young Hungarian-speaking adults. It can facilitate future research and public health initiatives aimed at improving FL and promoting healthy dietary habits. FAU - Keczeli, Viola AU - Keczeli V AUID- ORCID: 0000-0001-7044-0106 AD - Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pecs, 7621 Pecs, Hungary. FAU - Kisbenedek, Andrea Gubicskone AU - Kisbenedek AG AD - Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pecs, 7621 Pecs, Hungary. AD - Institute of Nutritional Sciences and Dietetics, Faculty of Health Sciences, University of Pecs, 7621 Pecs, Hungary. FAU - Makai, Alexandra AU - Makai A AUID- ORCID: 0000-0002-1907-120X AD - Institute of Physiotherapy and Sport Sciences, Faculty of Health Sciences, University of Pecs, 7621 Pecs, Hungary. FAU - Verzar, Zsofia AU - Verzar Z AUID- ORCID: 0000-0001-5323-0748 AD - Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pecs, 7621 Pecs, Hungary. LA - eng PT - Journal Article PT - Validation Study DEP - 20250526 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Male MH - Hungary MH - Reproducibility of Results MH - *Health Literacy MH - Young Adult MH - Adult MH - Surveys and Questionnaires/standards MH - Psychometrics MH - *Diet, Healthy MH - Students/psychology MH - Adolescent MH - Factor Analysis, Statistical MH - Translations PMC - PMC12157264 OTO - NOTNLM OT - Short Food Literacy Questionnaire OT - food literacy OT - health literacy OT - questionnaire validation OT - young adults COIS- The authors declare no conflicts of interest. EDAT- 2025/06/13 06:35 MHDA- 2025/06/13 06:36 PMCR- 2025/05/26 CRDT- 2025/06/13 01:01 PHST- 2025/04/29 00:00 [received] PHST- 2025/05/19 00:00 [revised] PHST- 2025/05/23 00:00 [accepted] PHST- 2025/06/13 06:36 [medline] PHST- 2025/06/13 06:35 [pubmed] PHST- 2025/06/13 01:01 [entrez] PHST- 2025/05/26 00:00 [pmc-release] AID - nu17111796 [pii] AID - nutrients-17-01796 [pii] AID - 10.3390/nu17111796 [doi] PST - epublish SO - Nutrients. 2025 May 26;17(11):1796. doi: 10.3390/nu17111796. PMID- 40507059 OWN - NLM STAT- MEDLINE DCOM- 20250613 LR - 20250615 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 11 DP - 2025 May 24 TI - The Conclusive and Continuous Tool to Assess Severity and Improvement of Eating Disorders (CONTASI-ED): Development and Psychometric Properties. LID - 10.3390/nu17111790 [doi] LID - 1790 AB - Background: Accurately assessing eating disorder (ED) severity and treatment progress is essential for effective intervention. The Comprehensive and Continuous Tool to Assess Severity and Improvement of Eating Disorders (CONTASI-ED) was developed to address limitations in existing assessments by incorporating behavioral, cognitive, and physiological markers. Objectives: This study aimed to examine the psychometric properties and sensitivity to symptom changes of the CONTASI-ED in a community-based clinical sample of women with ED. Methods: Participants were 58 females diagnosed with EDs and 10 healthy controls. The CONTASI-ED assessments were conducted over multiple time points in outpatient and intensive treatment settings. We examined reliability, validity, and sensitivity to treatment-related change. The CONTASI-ED scores were compared with EAT-26, and multivariable analyses explored the effects of body mass index (BMI), age, and post-traumatic stress disorder (PTSD) on symptom trajectories. Results: The CONTASI-ED demonstrated strong reliability, with test-retest correlations between 0.72 and 0.90 and inter-rater reliability of 0.68-0.95. The tool effectively distinguished ED patients from healthy controls (p < 0.001) and correlated strongly with EAT-26. Significant reductions in the CONTASI-ED scores over time (p < 0.001) reflected treatment-related improvements-although temporary score increases highlighted greater self-awareness and symptom disclosure. BMI, age, and PTSD significantly influenced symptom severity and treatment response. Conclusions: The CONTASI-ED demonstrated strong reliability and validity in distinguishing clinical and non-clinical cases and in tracking treatment-related changes. However, the findings are based on a relatively small, all-female sample, underscoring the need for further validation in more diverse populations. FAU - Golan, Moria AU - Golan M AUID- ORCID: 0000-0002-3798-1741 AD - Department of Nutritional Sciences, Tel Hai College, North Galilee, Qiryat Shemona 1220800, Israel. AD - SHAHAF-A Community-Based Facility for Treatment of Eating Disorders, Ganey Hadar 7683000, Israel. FAU - Sides, Roni AU - Sides R AD - SHAHAF-A Community-Based Facility for Treatment of Eating Disorders, Ganey Hadar 7683000, Israel. FAU - Baum, Keren AU - Baum K AD - SHAHAF-A Community-Based Facility for Treatment of Eating Disorders, Ganey Hadar 7683000, Israel. FAU - Arbib, Rachel AU - Arbib R AD - SHAHAF-A Community-Based Facility for Treatment of Eating Disorders, Ganey Hadar 7683000, Israel. FAU - Abu Ahmad, Wiessam AU - Abu Ahmad W AD - Braun School of Public Health, Hebrew University-Hadassah, Jerusalem 91120, Israel. LA - eng PT - Journal Article DEP - 20250524 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - *Psychometrics MH - *Feeding and Eating Disorders/diagnosis/psychology/therapy MH - Reproducibility of Results MH - Adult MH - *Severity of Illness Index MH - Young Adult MH - Body Mass Index MH - Middle Aged MH - Surveys and Questionnaires MH - Case-Control Studies MH - Adolescent PMC - PMC12157281 OTO - NOTNLM OT - assessment OT - eating disorders OT - longitudinal OT - psychometric properties OT - severity COIS- The authors declare no conflicts of interest. EDAT- 2025/06/13 06:34 MHDA- 2025/06/13 06:35 PMCR- 2025/05/24 CRDT- 2025/06/13 01:01 PHST- 2025/04/22 00:00 [received] PHST- 2025/05/20 00:00 [revised] PHST- 2025/05/23 00:00 [accepted] PHST- 2025/06/13 06:35 [medline] PHST- 2025/06/13 06:34 [pubmed] PHST- 2025/06/13 01:01 [entrez] PHST- 2025/05/24 00:00 [pmc-release] AID - nu17111790 [pii] AID - nutrients-17-01790 [pii] AID - 10.3390/nu17111790 [doi] PST - epublish SO - Nutrients. 2025 May 24;17(11):1790. doi: 10.3390/nu17111790. PMID- 40507027 OWN - NLM STAT- MEDLINE DCOM- 20250613 LR - 20250615 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 11 DP - 2025 May 23 TI - Feeding Difficulties in Children with Hepatic Glycogen Storage Diseases Identified by a Brazilian Portuguese Validated Screening Tool. LID - 10.3390/nu17111758 [doi] LID - 1758 AB - Background/Objectives: Hepatic glycogen storage diseases (GSDs) are inherited metabolic disorders that affect glycogen synthesis or breakdown, primarily involving the liver and muscles. Treatment typically consists of strict dietary management, including the consumption of uncooked cornstarch. However, there is limited research on feeding challenges and the associated stress experienced by parents of children with GSDs. This study aims to assess feeding difficulties in children with GSDs and the level of parental stress. Methods: A total of 29 caregivers of children aged 6 months to <7 years participated. Feeding difficulties were evaluated using the Brazilian Infant Feeding Scale (Escala Brasileira de Alimentacao Infantil-EBAI), while parental stress was measured using the Parental Stress Scale (Escala de Estresse Parental-EEPa). Data were collected in 2020, and the study was approved by the ethics committee. Results: The majority of the children were male (19/10), with a mean age of 47.75 months and an average age of diagnosis of 8.39 months. GSD type Ia (n = 15) and type Ib (n = 5) were the most prevalent, followed by types III and IX (n = 2). Among the participants, 22 out of 29 (76%) reported feeding difficulties, categorized as mild (n = 7, 24%), moderate (n = 7, 24%), and severe (n = 8, 28%). EBAI scores were higher in female patients and in those who did not eat meals with their family. Only one caregiver exhibited high levels of parental stress, as measured by the EEPA scale. No significant correlation was found between feeding difficulties and parental stress. Conclusions: The findings confirm a high prevalence of feeding issues in children with GSDs, which significantly affects caregivers' quality of life. Although no significant link between feeding difficulties and parental stress was identified, further research is needed to improve GSD management and provide better support for caregivers. FAU - Sartor, Barbara Cristina Pezzi AU - Sartor BCP AD - Hospital Materno Infantil Presidente Vargas, Porto Alegre 90035-074, Brazil. FAU - de Oliveira, Bibiana Mello AU - de Oliveira BM AUID- ORCID: 0000-0002-2679-6858 AD - Postgraduate Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul, Porto Alegre 91509-900, Brazil. FAU - Teruya, Katia Irie AU - Teruya KI AD - Postgraduate Program Psychology, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-002, Brazil. FAU - Farret, Lilia Ramos AU - Farret LR AD - Medical Genetics Service, Hospital de Clinicas de Porto Alegre, Porto Alegre 90035-903, Brazil. FAU - Tonon, Tassia AU - Tonon T AD - Postgraduate Program in Medical Sciences Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, Brazil. FAU - Scortegagna, Mariana Lima AU - Scortegagna ML AUID- ORCID: 0000-0002-9050-3343 AD - Postgraduate Program in Medical Sciences Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, Brazil. FAU - Diniz, Patricia Barcellos AU - Diniz PB AD - Hospital Materno Infantil Presidente Vargas, Porto Alegre 90035-074, Brazil. FAU - de Souza, Carolina Fischinger Moura AU - de Souza CFM AUID- ORCID: 0000-0002-7280-6260 AD - Postgraduate Program in Child and Adolescent Health, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, Brazil. AD - Clinical Research Service, Hospital de Clinicas de Porto Alegre, Porto Alegre 90035-003, Brazil. LA - eng PT - Journal Article DEP - 20250523 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Female MH - Brazil/epidemiology MH - Child, Preschool MH - Infant MH - *Glycogen Storage Disease/complications/psychology/physiopathology MH - *Parents/psychology MH - Child MH - Stress, Psychological MH - Caregivers/psychology MH - *Feeding Behavior PMC - PMC12158202 OTO - NOTNLM OT - feeding and eating disorders OT - glycogen storage disease OT - parent-child relations OT - psychological distress COIS- The authors declare no conflicts of interest. EDAT- 2025/06/13 06:34 MHDA- 2025/06/13 06:35 PMCR- 2025/05/23 CRDT- 2025/06/13 01:01 PHST- 2025/03/28 00:00 [received] PHST- 2025/05/02 00:00 [revised] PHST- 2025/05/10 00:00 [accepted] PHST- 2025/06/13 06:35 [medline] PHST- 2025/06/13 06:34 [pubmed] PHST- 2025/06/13 01:01 [entrez] PHST- 2025/05/23 00:00 [pmc-release] AID - nu17111758 [pii] AID - nutrients-17-01758 [pii] AID - 10.3390/nu17111758 [doi] PST - epublish SO - Nutrients. 2025 May 23;17(11):1758. doi: 10.3390/nu17111758. PMID- 40507017 OWN - NLM STAT- MEDLINE DCOM- 20250613 LR - 20250615 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 11 DP - 2025 May 22 TI - The Gut Microbiota in Young Adults with High-Functioning Autism Spectrum Disorder and Its Performance as Diagnostic Biomarkers. LID - 10.3390/nu17111748 [doi] LID - 1748 AB - Background/Objectives: Diagnosing ASD in adults presents unique challenges, and there are currently no specific biomarkers for this condition. Most existing studies on the gut microbiota in ASD are conducted in children; however, the composition of the gut microbiota in children differs significantly from that of adults. This study aimed to study the gut microbiota of young adults with high-functioning ASD. Methods: Using metagenomic sequencing, we evaluated the gut microbiota in 45 adults with high-functioning ASD and 45 matched healthy controls. Results: Adjusting for sociodemographic information, dietary habits, and clinical data, we observed a distinct microbiota profile of adults with ASD in comparison to controls, with the intensity of autistic traits strongly correlating to microbial diversity (correlation coefficient = -0.351, p-value < 0.001). Despite a similar dietary pattern, the ASD group exhibited more gastrointestinal symptoms than the healthy controls. An internally validated machine-learning predictive model that combines the Autism Spectrum Quotient questionnaire score of individuals with their microbial features could achieve an area under the receiver operating characteristic curve (AUC) of 0.955 in diagnosing ASD in adults. Conclusions: This study evaluates the gut microbiota in adult ASD and highlights its potential as a non-invasive biomarker to enhance the diagnosis of ASD in this population group. FAU - Ying, Jiangbo AU - Ying J AD - Department of Developmental Psychiatry & East Region, Institute of Mental Health, Singapore 539747, Singapore. FAU - Xu, Xinran AU - Xu X AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore. FAU - Zhou, Ruwen AU - Zhou R AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore. FAU - Chung, Arthur C K AU - Chung ACK AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore. FAU - Ng, Siu Kin AU - Ng SK AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore. FAU - Fan, Xiuyi AU - Fan X AUID- ORCID: 0000-0003-1223-9986 AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore. FAU - Subramaniam, Mythily AU - Subramaniam M AUID- ORCID: 0000-0003-4530-1096 AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore. AD - Research Division, Institute of Mental Health, Singapore 539747, Singapore. FAU - Wong, Sunny H AU - Wong SH AUID- ORCID: 0000-0002-3354-9310 AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore. AD - Department of Gastroenterology and Hepatology, Tan Tock Sen Hospital, Singapore 308433, Singapore. LA - eng GR - Nil/NHG-LKCMedicine Clinician-Scientist Preparatory Programme Plus/ PT - Journal Article DEP - 20250522 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Gastrointestinal Microbiome MH - *Autism Spectrum Disorder/microbiology/diagnosis MH - Male MH - Female MH - Biomarkers MH - Young Adult MH - Adult MH - Case-Control Studies MH - Feces/microbiology MH - Metagenomics MH - Machine Learning MH - ROC Curve MH - Adolescent PMC - PMC12158130 OTO - NOTNLM OT - adult OT - autism OT - biomarker OT - diagnostic tool OT - gut microbiota COIS- The authors declare no conflicts of interest. EDAT- 2025/06/13 06:34 MHDA- 2025/06/13 06:35 PMCR- 2025/05/22 CRDT- 2025/06/13 01:01 PHST- 2025/04/22 00:00 [received] PHST- 2025/05/19 00:00 [revised] PHST- 2025/05/20 00:00 [accepted] PHST- 2025/06/13 06:35 [medline] PHST- 2025/06/13 06:34 [pubmed] PHST- 2025/06/13 01:01 [entrez] PHST- 2025/05/22 00:00 [pmc-release] AID - nu17111748 [pii] AID - nutrients-17-01748 [pii] AID - 10.3390/nu17111748 [doi] PST - epublish SO - Nutrients. 2025 May 22;17(11):1748. doi: 10.3390/nu17111748. PMID- 40498668 OWN - NLM STAT- MEDLINE DCOM- 20250611 LR - 20260729 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 9 DP - 2025 Jun 11 TI - Smartphone Ecological Momentary Assessment and Wearable Activity Tracking in Pediatric Depression: Cohort Study. PG - e66187 LID - 10.2196/66187 [doi] LID - e66187 AB - BACKGROUND: Adolescent depression is a significant public health concern. The presentation of depressive symptoms varies widely among individuals, fluctuating in intensity over time. Ecological momentary assessment (EMA) offers a unique advantage by enhancing ecological validity and reducing recall bias, allowing for a more accurate and nuanced understanding of major depressive disorder (MDD) symptoms. This methodology provides valuable insights into the fluctuating nature of depression, which could inform more personalized and timely interventions. OBJECTIVE: This study aims to (1) evaluate the feasibility of collecting smartphone-based EMA data alongside activity and sleep tracking in adolescents with depression; (2) investigate the severity and variability of mood symptoms reported over time; and (3) explore the relationship between mood, activity, and sleep. METHODS: Thirty-six participants (23 with MDD, 13 unaffected controls; 75% [n=27] female, mean age 19.50 y) completed twice-daily EMA check-ins over 2 weeks, complemented by continuous activity and sleep monitoring using FitBit Charge 3 devices. The study examined feasibility, usability of the EMA app, symptom severity and variability, and relationships between mood, activity, and sleep. We applied linear mixed-effects regression to the data to examine relationships between variables. RESULTS: Participants completed a total of 923 unique check-ins (mean check-ins per participant=25.60). Overall compliance rates were high (91.57%), indicating the approach is highly feasible. MDD participants demonstrated greater symptom severity and variability over time compared with controls (beta=34.48, P<.001). Individuals with MDD exhibited greater diurnal variation (beta=-2.54, P<.001) with worse mood in the morning and worse mood than anxiety scores over time (beta=-6.93, P<.001). Life stress was a significant predictor of more severe EMA scores (beta=24.50, P<.001). MDD cases exhibited more inconsistent sleep patterns (beta=32.14, P<.001), shorter total sleep times (beta=-94.38, P<.001), and a higher frequency of naps (beta=14.05, P<.001). MDD cases took fewer steps per day (mean 5828.64, SD 6188.85) than controls (mean 7088.47, SD 5378.18) over the course of the study, but this difference was not significant (P=.33), and activity levels were not significantly predictive of EMA score (P=.75). CONCLUSIONS: This study demonstrates the feasibility of integrating smartphone-based EMA with wearable activity tracking in adolescents with depression. High compliance rates support the practicality of this approach, while EMA data provide valuable insights into the dynamic nature of depressive symptoms, particularly in relation to sleep and life stress. Future studies should validate these findings in larger, more diverse samples. Clinically, EMA and wearable tracking may enhance routine assessments and inform personalized interventions by capturing symptom variability and external influences in real time. CI - (c)Jimena Unzueta Saavedra, Emma A Deaso, Margot Austin, Laura Cadavid, Rachel Kraff, Emma E M Knowles. Originally published in JMIR Formative Research (https://formative.jmir.org). FAU - Unzueta Saavedra, Jimena AU - Unzueta Saavedra J AUID- ORCID: 0009-0008-1687-469X AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02445, United States, 1 6179194628. FAU - Deaso, Emma A AU - Deaso EA AUID- ORCID: 0009-0007-1287-0555 AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02445, United States, 1 6179194628. FAU - Austin, Margot AU - Austin M AUID- ORCID: 0009-0009-2578-9179 AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02445, United States, 1 6179194628. FAU - Cadavid, Laura AU - Cadavid L AUID- ORCID: 0009-0008-4616-8841 AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02445, United States, 1 6179194628. FAU - Kraff, Rachel AU - Kraff R AUID- ORCID: 0009-0003-8562-7557 AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02445, United States, 1 6179194628. FAU - Knowles, Emma E M AU - Knowles EEM AUID- ORCID: 0000-0003-0642-267X AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02445, United States, 1 6179194628. AD - Harvard Medical School, 25 Shattuck Street, Boston, MA, United States. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250611 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - Female MH - *Ecological Momentary Assessment MH - Male MH - *Smartphone MH - Adolescent MH - Young Adult MH - Cohort Studies MH - *Major Depressive Disorder/psychology/diagnosis/physiopathology MH - Sleep/physiology MH - *Wearable Electronic Devices MH - Feasibility Studies MH - Affect MH - Mobile Applications MH - Exercise MH - Adult PMC - PMC12175877 OTO - NOTNLM OT - activity OT - adolescent OT - depression OT - ecological momentary assessment OT - mood OT - sleep COIS- Conflicts of Interest: None declared. EDAT- 2025/06/11 22:57 MHDA- 2025/06/11 22:58 PMCR- 2025/06/11 CRDT- 2025/06/11 13:12 PHST- 2024/09/09 00:00 [received] PHST- 2025/02/10 00:00 [revised] PHST- 2025/02/11 00:00 [accepted] PHST- 2025/06/11 22:58 [medline] PHST- 2025/06/11 22:57 [pubmed] PHST- 2025/06/11 13:12 [entrez] PHST- 2025/06/11 00:00 [pmc-release] AID - v9i1e66187 [pii] AID - 66187 [pii] AID - 10.2196/66187 [doi] PST - epublish SO - JMIR Form Res. 2025 Jun 11;9:e66187. doi: 10.2196/66187. PMID- 40495176 OWN - NLM STAT- MEDLINE DCOM- 20250610 LR - 20250613 IS - 1475-925X (Electronic) IS - 1475-925X (Linking) VI - 24 IP - 1 DP - 2025 Jun 10 TI - Global, regional, and national burden of acute leukemia and its risk factors from 1990 to 2021 and predictions to 2040: findings from the global burden of disease study 2021. PG - 72 LID - 10.1186/s12938-025-01403-7 [doi] LID - 72 AB - BACKGROUND: Despite therapeutic advances, acute leukemia (AL) continues to impose a substantial global health burden, with persistently high incidence and mortality rates. Notably, the prediction is that the number of incidence and mortality of acute myeloid leukemia (AML) cases will continue to increase to 184,287.88 and 165,537.59, respectively, by 2040. Using Global Burden of Disease Study (GBD) 2021 data, we assessed the worldwide AL burden from 1990 to 2021, analyzing trends by sex to inform public health strategies. METHODS: To delineate the burden of AL, we reported incidence, prevalence, mortality, and disability-adjusted life year (DALY) rates at global, regional, and national levels, with these estimates including age-standardized rates (ASRs) per 100,000 population and average annual percentage changes (AAPCs) from 1990 to 2021 which were stratified by age, sex, and socio-demographic index (SDI), and computed ASRs and AAPCs using linear regression. Temporal trends were analyzed using an age-period-cohort (APC) model with intrinsic estimation (principal component regression). Risk factor attribution quantified contributions of 21 behavioral, environmental, and metabolic exposures to AL-related DALYs. For inequality assessment, we applied the Slope Index of Inequality and Concentration Index to evaluate absolute and relative disparities in AL burden across regions and countries. Future projections (2040) were modeled via a Bayesian APC framework with Integrated Nested Laplace Approximation. All statistical analyses were performed using R software (version R 4.4.1). The GATHER (Guidelines for Accurate and Transparent Health Estimates Reporting) statement provides a framework to ensure the transparency, reproducibility, and quality of health estimates reporting. RESULTS: Between 1990 and 2021, global ASRs of AL declined, except for acute lymphoblastic leukemia (ALL) age-standardized prevalence rates (ASPR) (AAPC 0.84, 95% CI 0.59-1.10). Case numbers rose overall, though ALL mortality and DALYs decreased. AML burden correlated positively with SDI (rho > 0, P < 0.001), with the highest number of incident and mortality cases in Western Europe. For ALL, SDI showed positive associations with ASIR and ASPR (rho > 0, P < 0.001) but negative correlations with ASMR and ASDALR (rho < 0, P < 0.001), with East Asia being the most severely affected region. High body mass index (BMI), smoking, and benzene/formaldehyde exposure were key AL DALY risk factors. High BMI and smoking predominate in developed countries, and the proportion of DALYs decreases progressively as SDI decreases. Occupational exposures prevailed in developing countries. Population growth drove most absolute increases. Males bore a greater AL burden. AML risk rose with age, whereas ALL displayed bimodal peaks (< 5 and > 40 years). Notably, while ASRs in AL are projected to decline slightly and the number of ALL to decrease by 2040, the number of AML is expected to increase, with the number of incidence and mortality cases increasing by 41.56% and 27.16%, respectively. CONCLUSION: As a major public health concern, despite declining ALL-related mortality and DALYs (1990-2021), AL remains a growing global health challenge, with AML cases projected to rise significantly by 2040. Region-specific intervention strategies are required: high-SDI nations should prioritize smoking cessation and metabolic control to address smoking and high BMI-related AML risks while preparing for aging populations, whereas low/middle-SDI countries urgently need enhanced pediatric ALL diagnosis, treatment capacity, and occupational safety measures. Effective mitigation demands evidence-based health planning, including resource allocation guided by projected AL burden trends and targeted policy interventions to reduce healthcare disparities. CI - (c) 2025. The Author(s). FAU - Han, Xinpu AU - Han X AD - Department of Oncology and Hematology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China. AD - Beijing University of Chinese Medicine, Beijing, 100029, China. FAU - Yun, Zhangjun AU - Yun Z AD - Department of Oncology and Hematology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China. AD - Beijing University of Chinese Medicine, Beijing, 100029, China. FAU - Liu, Zhu AU - Liu Z AD - Department of Oncology and Hematology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China. AD - Beijing University of Chinese Medicine, Beijing, 100029, China. FAU - Si, Yuping AU - Si Y AD - Department of Oncology and Hematology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China. AD - Beijing University of Chinese Medicine, Beijing, 100029, China. FAU - Tian, Shaodan AU - Tian S AD - Department of Oncology and Hematology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China. FAU - Zhang, Yu AU - Zhang Y AD - Department of Oncology and Hematology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China. FAU - Qi, Yubo AU - Qi Y AD - Department of Oncology and Hematology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China. FAU - Xue, Chengyuan AU - Xue C AD - Department of Oncology and Hematology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China. AD - Beijing University of Chinese Medicine, Beijing, 100029, China. FAU - Cui, Meichen AU - Cui M AD - Department of Oncology and Hematology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China. AD - Beijing University of Chinese Medicine, Beijing, 100029, China. FAU - Wen, Xu AU - Wen X AD - Department of Oncology and Hematology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China. AD - Beijing University of Chinese Medicine, Beijing, 100029, China. FAU - Zhang, Yayue AU - Zhang Y AD - Department of Oncology and Hematology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China. yayuezhang@126.com. FAU - Hou, Li AU - Hou L AD - Department of Oncology and Hematology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China. houli1203@126.com. LA - eng GR - 7242236/the Natural Science Foundation of Beijing/ GR - CZ015/the Leading Talents Project of Dongzhimen Hospital, Beijing University of Chinese Medicine/ GR - zyyzdxk-2023268/National Administration of Traditional Chinese Medicine High level Key Discipline Construction Project of Traditional Chinese Medicine Hematology/ GR - 82074240/the National Natural Science Foundation of China/ PT - Journal Article DEP - 20250610 PL - England TA - Biomed Eng Online JT - Biomedical engineering online JID - 101147518 SB - IM MH - Humans MH - Risk Factors MH - *Global Burden of Disease MH - Male MH - Female MH - *Leukemia, Myeloid, Acute/epidemiology/mortality MH - Middle Aged MH - Adult MH - Adolescent MH - Aged MH - Young Adult MH - Child MH - Disability-Adjusted Life Years MH - Child, Preschool MH - Incidence MH - Infant PMC - PMC12150532 OTO - NOTNLM OT - Acute leukemia OT - COVID-19 OT - Epidemiology OT - Forecasting OT - Global burden of disease OT - Risk factors COIS- Declarations. Ethics approval and consent to participate: All data in this study were derived from publicly available summary data and no additional ethical review was required. For the GBD study, the use of deidentified data was granted a waiver of informed consent by the University of Washington Institutional Review Board. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/06/11 00:27 MHDA- 2025/06/11 00:28 PMCR- 2025/06/10 CRDT- 2025/06/10 23:35 PHST- 2025/01/06 00:00 [received] PHST- 2025/05/27 00:00 [accepted] PHST- 2025/06/11 00:28 [medline] PHST- 2025/06/11 00:27 [pubmed] PHST- 2025/06/10 23:35 [entrez] PHST- 2025/06/10 00:00 [pmc-release] AID - 10.1186/s12938-025-01403-7 [pii] AID - 1403 [pii] AID - 10.1186/s12938-025-01403-7 [doi] PST - epublish SO - Biomed Eng Online. 2025 Jun 10;24(1):72. doi: 10.1186/s12938-025-01403-7. PMID- 40493886 OWN - NLM STAT- MEDLINE DCOM- 20250925 LR - 20260520 IS - 1866-0452 (Electronic) IS - 1866-0452 (Linking) VI - 122 IP - 17 DP - 2025 Aug 22 TI - Point Prevalence and Risk Factors for Insomnia in Children and Adolescents: Findings of a Population-Based Survey. PG - 461-466 LID - arztebl.m2025.0096 [pii] LID - 10.3238/arztebl.m2025.0096 [doi] AB - BACKGROUND: Insomnia in children and adolescents can be associated with poorer cognitive, emotional, social, and academic development. At present, no estimates of the prevalence of insomnia and its risk factors among adolescents in Germany are available from which the potential need for treatment could be assessed. METHODS: We conducted an online survey of a representative German sample of 1128 children and adolescents (age 10-17) and one parent for each. Levels of severity of insomnia as defined by the ICD-11 criteria were assessed by means of standardized selfreporting with use of the internationally established Insomnia Severity Index. The point prevalences of the levels of severity were calculated via relative frequencies. Potential risk factors for insomnia (sociodemographic factors, obesity, media consumption time, depression, anxiety, parental insomnia) were assessed with validated screening questionnaires and investigated in a multinomial regression model for the prediction of insomnia in childhood. RESULTS: The following point prevalences were determined: mild insomnia, 26.6%; moderate insomnia, 21.4%; severe insomnia, 1.6%. The most important risk factors for moderate and severe insomnia were existing anxiety (odds ratio and 95% confidence interval 4.54 [2.09; 9.88] and 7.96 [1.72; 36.94], respectively) and parental insomnia (2.49 [1.66; 3.72] and 3.30 [1.06; 10.30], respec tively). The most important risk factor for mild and moderate insomnia was depression (1.83 [1.49; 2.24]), while older age (adolescents versus 10- to 13-year-olds) was protective ([0.51; 1.00]). CONCLUSION: Many children and adolescents meet the ICD-11 criteria for insomnia according to their self-assessment. Critical life events and stressful experiences were not found to have any significant association with insomnia. A primarily nonpharmacological treatment approach involving the child and parents is indicated to alleviate the, often considerable, psychological strain on the family and prevent chronification of insomnia with adverse effects on the development of the child. FAU - Wieder, Magdalena AU - Wieder M AD - German Center for Addiction Research in Childhood and Adolescence (DZSKJ), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. FAU - Thomasius, Rainer AU - Thomasius R FAU - Paschke, Kerstin AU - Paschke K LA - eng PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't PL - Germany TA - Dtsch Arztebl Int JT - Deutsches Arzteblatt international JID - 101475967 SB - IM MH - Humans MH - *Sleep Initiation and Maintenance Disorders/epidemiology/diagnosis MH - Adolescent MH - Child MH - Germany/epidemiology MH - Male MH - Female MH - Risk Factors MH - Prevalence MH - Comorbidity MH - *Anxiety/epidemiology MH - Age Distribution MH - Depression/epidemiology PMC - PMC12599178 EDAT- 2025/06/10 18:27 MHDA- 2025/09/25 12:43 PMCR- 2025/08/01 CRDT- 2025/06/10 16:12 PHST- 2025/01/22 00:00 [received] PHST- 2025/05/20 00:00 [revised] PHST- 2025/05/20 00:00 [accepted] PHST- 2025/09/25 12:43 [medline] PHST- 2025/06/10 18:27 [pubmed] PHST- 2025/06/10 16:12 [entrez] PHST- 2025/08/01 00:00 [pmc-release] AID - arztebl.m2025.0096 [pii] AID - 10.3238/arztebl.m2025.0096 [doi] PST - ppublish SO - Dtsch Arztebl Int. 2025 Aug 22;122(17):461-466. doi: 10.3238/arztebl.m2025.0096. PMID- 40493113 OWN - NLM STAT- MEDLINE DCOM- 20250730 LR - 20260703 IS - 0974-7559 (Electronic) IS - 0019-6061 (Linking) VI - 62 IP - 8 DP - 2025 Aug TI - Consensus Guidelines of the Indian Academy of Pediatrics (IAP)-Neurodevelopmental Pediatrics Chapter on Developmentally Supportive Follow-Up for High-Risk Infants. PG - 554-573 LID - 10.1007/s13312-025-00110-9 [doi] AB - JUSTIFICATION: With increasing neonatal survival, there is a need for trained staff for timely identification and intervention for high-risk infants. Since the foundation of neurodevelopment is laid in the first three years of life, addressing the lacunae of a robust guidelines for extended follow-up of high-risk infants needs to be formulated to avoid remediation or rehabilitation later on. OBJECTIVES: To develop comprehensive evidence-based consensus guidelines for developmentally supportive care and follow-up of high-risk infants in the Indian context with the aim of reducing the need for future rehabilitative services. PROCESS: Scientific literature over the last 10 years was searched using database-specific controlled vocabularies like Emtree for Embase, MeSH terms for PubMed, Scopus, CINAHL headings for CINAHL databases, and the Cochrane Library. The available studies were analyzed based on their scientific credibility and strength of evidence. Data from meta-analysis, systematic reviews, and randomized controlled trials was extracted, and relevant statements were prepared. These were deliberated in two onsite Delphi rounds of discussion (February 19, 2023 and January 11, 2025) and one hybrid (online and onsite) Delphi round (February 6, 2025). The final draft was made under different headings and was circulated, followed by recommendations made with Grading of Recommendations Assessment, Development and Evaluation (GRADE) analysis. The final draft after incorporating all suggestions was circulated and accepted online on March 2, 2025. STATEMENT: The recommendations propose using a color-coded system to monitor high-risk infants, risk stratification, promoting early stimulation, structured interventions, and parental involvement. Routine care should align with the infant's behavioral state and use validated screening tools and growth charts. Comprehensive follow-ups, including screening for retinopathy of prematurity, thyroid disorders, developmental dysplasia of hip, and hearing impairments, are essential, with specialized therapies provided as needed. Structured follow-up guidelines are likely to improve the selection of high-risk infants, plan follow-up, and guide pediatricians on screening, evaluation, early stimulation, intervention, and plan-specific definitive therapies with rehabilitation therapists which would ultimately decrease the childhood disability. CI - (c) 2025. The Author(s), under exclusive licence to Indian Academy of Pediatrics. FAU - Meenai, Zafar Mahmood AU - Meenai ZM AD - Ummeid Group of Child Development Centers, Bhopal, Madhya Pradesh, India. drzafarah@gmail.com. FAU - Nair, M K C AU - Nair MKC AD - NIMS-SPECTRUM-Child Development Research Centre (CDRC) NIMS Medicity, Thiruvananthapuram, Kerala, India. FAU - Dalwai, Samir AU - Dalwai S AD - New Horizons Child Development Centre, Mumbai, Maharashtra, India. FAU - Nair, Lal D V AU - Nair LDV AD - Child Development Centre, Saveetha Medical College, Chennai, Tamil Nadu, India. FAU - Gulati, Sheffali AU - Gulati S AD - Centre of Excellence and Advanced Research for Childhood Neurodevelopmental Disorders and Child Neurology Division, AIIMS, New Delhi, India. FAU - Mukherjee, Sharmila B AU - Mukherjee SB AD - Lady Hardinge Medical College and Kalawati Saran Children's Hospital, New Delhi, India. FAU - Jain, Naveen AU - Jain N AD - Kerala Institute of Medical Sciences, Anayara, Thiruvanthapuram, Kerala, India. FAU - Dwivedi, Deepak AU - Dwivedi D AD - SS Medical College, Rewa, Madhya Pradesh, India. FAU - Multani, Kawaljit S AU - Multani KS AD - Chairperson IAP-NDP-2024, Punjab, India. FAU - Seth, Shambhavi AU - Seth S AD - HSG IAP-NDP, Bright Beginnings CDC, New Delhi, India. FAU - Singh, Vivek V AU - Singh VV AD - UNICEF India Country Office, New Delhi, India. FAU - Bhadra, Atanu AU - Bhadra A AD - Treasurer, IAP 2024-25, IAP Office, Mumbai, Maharashtra, India. FAU - Khalatkar, Vasant AU - Khalatkar V AD - National President, IAP 2025, IAP Office, Mumbai, Maharashtra, India. FAU - Kraleti, Santhosh K AU - Kraleti SK AD - Member NMC and NHRC and Associate Dean School of Healthcare, Rishihood University, Sonepat, Haryana, India. FAU - Juneja, Monica AU - Juneja M AD - Maulana Azad Medical College, New Delhi, India. FAU - Deshpande, Leena AU - Deshpande L AD - Apollo Hospitals and iCAN CDC, Navi Mumbai, Maharashtra, India. FAU - Bhattacharya, Anjan AU - Bhattacharya A AD - Nabjathak CDC, Kolkata, West Bengal, India. FAU - Bharti, Lalan Kumar AU - Bharti LK AD - President NNF 2025 and JPC Hospital, Government of NCT of Delhi, Delhi, India. FAU - Parikh, Yogesh AU - Parikh Y AD - HSG IAP 2024-25 and Government Medical College, New Civil Hospital Campus, Surat, Gujarat, India. FAU - Srivastava, Leena AU - Srivastava L AD - Bharati Vidyapeeth Medical College and Hospital, Pune, Maharashtra, India. FAU - Sadasivan, Sitaraman AU - Sadasivan S AD - ICP Office, Noida, Uttar Pradesh, India. FAU - Unni, Jeeson C AU - Unni JC AD - Aster Medicity, Cochin, Kerala, India. FAU - Sodhi, Manmeet K AU - Sodhi MK AD - Government Medical College, Amritsar, Punjab, India. FAU - Kumar, Shyamal AU - Kumar S AD - Reborn CDC, Dhanbad, Jharkand, India. FAU - Bhaskaran, Deepa AU - Bhaskaran D AD - CDC, Medical College, Thiruvananthapuram, Kerala, India. FAU - Eregowda, Adarsh AU - Eregowda A AD - Rajarajeswari Medical College, Bengluru, Karnataka, India. FAU - Surana, Indu AU - Surana I AD - Sri Jain Hospital, Howrah, West Bengal, India. FAU - Paul, Abraham K AU - Paul AK AD - Indra Gandhi Hospital, Child Care Centre, Cochin, Kerala, India. FAU - Rai, Ashok AU - Rai A AD - Indian Institute of Cerebral Palsy and Handicapped Children, Heritage Institute of Medical Sciences, Varanasi, Uttar Pradesh, India. FAU - Shivanna, Sanjay AU - Shivanna S AD - IGICH, Bengaluru, Karnataka, India. FAU - Wani, Khurshid AU - Wani K AD - Government Medical College, Srinagar, Jammu and Kashmir, India. FAU - Bhat, Lata AU - Bhat L AD - Palak CDC, Delhi, India. FAU - Ahmed, Shabina AU - Ahmed S AD - Assam Autism Foundation, Guwahati, Assam, India. FAU - Joseph, Nimmy K AU - Joseph NK AD - National Institute of Physical Education and Rehabilitation, Ernakulam, Kerala, India. LA - eng PT - Journal Article PT - Practice Guideline DEP - 20250610 PL - India TA - Indian Pediatr JT - Indian pediatrics JID - 2985062R SB - IM EIN - Indian Pediatr. 2025 Aug;62(8):638-639. doi: 10.1007/s13312-025-00128-z. PMID: 40694293 MH - Humans MH - Infant MH - Infant, Newborn MH - *Child Development MH - Consensus MH - India MH - *Pediatrics/standards MH - Review Literature as Topic OTO - NOTNLM OT - Developmental delay OT - Early intervention OT - Genetic disorders OT - Neurodevelopment OT - Rehabilitation COIS- Declarations. Conflict of interest: None. Ethics Approval: Not applicable. Consent to Participate: Not applicable as this is a recommendation framing exercise. Consent to Publish: Not applicable as this is a recommendation framing exercise; however, all authors have signed consent for publishing the final draft. Necessary permissions had also been obtained from the Indian Academy of Pediatrics for the same. Clinical Trial Number: Not applicable. EDAT- 2025/06/10 13:26 MHDA- 2025/07/30 12:30 CRDT- 2025/06/10 11:07 PHST- 2025/03/04 00:00 [received] PHST- 2025/05/08 00:00 [accepted] PHST- 2025/07/30 12:30 [medline] PHST- 2025/06/10 13:26 [pubmed] PHST- 2025/06/10 11:07 [entrez] AID - 10.1007/s13312-025-00110-9 [pii] AID - 10.1007/s13312-025-00110-9 [doi] PST - ppublish SO - Indian Pediatr. 2025 Aug;62(8):554-573. doi: 10.1007/s13312-025-00110-9. Epub 2025 Jun 10. PMID- 40493090 OWN - NLM STAT- MEDLINE DCOM- 20251125 LR - 20251128 IS - 1435-165X (Electronic) IS - 1018-8827 (Print) IS - 1018-8827 (Linking) VI - 34 IP - 11 DP - 2025 Nov TI - Maternal nut and fish consumption during pregnancy and child risky decision-making at 11 years old. PG - 3643-3654 LID - 10.1007/s00787-025-02750-5 [doi] AB - Antenatal diet may have a role in the development of impulsivity, and hence in risky decision-making. This study is assessing whether nut and fish consumption during pregnancy is associated with impulsivity and risky decision-making until pre-adolescence. This is a mother-child population-based birth cohort study, INMA (Infancia y Medio Ambiente) project (recruitment years 2004-2008). The final sample included 1386 healthy preadolescents and their mothers. The exposure variables included maternal nut and fish consumption during the first trimester of pregnancy from a validated food frequency questionnaire (FFQ). The main outcomes were impulsivity index (Attention Network Task, ANT) and the number of risky decision-making (Roulette Task). The association was estimated by multi-variable linear regression models. Children whose mothers were at the highest nut intake tertile showed less risky decision scores compared to those at the lowest tertile (beta = -1.49, 95%CI = -2.85; -0.14; p-for-trend = 0.03). Fish consumption showed a positive association with ANT impulsivity index (the coefficient for second quintile compared to the lowest beta = 65.73, 95%CI = 1.11; 130.35), with a p-value < 0.05 and a p-for-trend = 0.61. Although, no association was observed between fish consumption and risky decision-making outcome. Our study suggests that a higher nut intake during early pregnancy may be related with less risky decision-making in the 11-year-old children. Also, that a moderate intake of fish during early pregnancy seems to be associated with higher impulsivity in the offspring. The latter finding may be indicative of no benefits observed from seafood consumption. CI - (c) 2025. The Author(s). FAU - Rivera, Marina Ruiz AU - Rivera MR AD - Clinical and Epidemiological Neuroscience (NeuroEpia), Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Catalonia, 43204, Spain. AD - Barcelona Institute for Global Health (ISGlobal) - Campus MAR, PRBB, Barcelona, Catalonia, Spain. AD - Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain. FAU - Pinar-Marti, Ariadna AU - Pinar-Marti A AUID- ORCID: 0000-0002-2602-3396 AD - Clinical and Epidemiological Neuroscience (NeuroEpia), Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Catalonia, 43204, Spain. AD - Barcelona Institute for Global Health (ISGlobal) - Campus MAR, PRBB, Barcelona, Catalonia, Spain. AD - Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain. FAU - Babarro, Izaro AU - Babarro I AD - Faculty of Psychology, University of the Basque Country (UPV/EHU), Donostia/San Sebastian, 20018, Spain. FAU - Ibarluzea, Jesus AU - Ibarluzea J AD - Faculty of Psychology, University of the Basque Country (UPV/EHU), Donostia/San Sebastian, 20018, Spain. AD - Group of Environmental Epidemiology and Child Development, Biodonostia Health Research Institute, Donostia/San Sebastian, 20014, Spain. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, 28029, Spain. AD - Sub-Directorate for Public Health and Addictions of Gipuzkoa, Ministry of Health of the Basque Government, Donostia/San Sebastian, 20013, Spain. FAU - Vioque, Jesus AU - Vioque J AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, 28029, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante, Universidad Miguel Hernandez (ISABIAL-UMH), Alicante, 03010, Spain. FAU - Llop, Sabrina AU - Llop S AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, 28029, Spain. AD - Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I- Universitat de Valencia, Valencia, Spain. FAU - Fernandez-Somoano, Ana AU - Fernandez-Somoano A AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, 28029, Spain. AD - IUOPA Public Health Department, University of Oviedo, Asturias, Spain. AD - Institute of Health Research of the Principality of Asturias-Foundation for Biosanitary Research of Asturias (ISPA- FINBA), Oviedo, Asturias, Spain. FAU - Tardon, Adonina AU - Tardon A AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, 28029, Spain. AD - IUOPA Public Health Department, University of Oviedo, Asturias, Spain. AD - Institute of Health Research of the Principality of Asturias-Foundation for Biosanitary Research of Asturias (ISPA- FINBA), Oviedo, Asturias, Spain. FAU - Pascual-Rubio, Vicenc AU - Pascual-Rubio V AD - NeuroEpia Group, Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Hospital Universitari Sant Joan de Reus, 43204 Reus (Tarragona), Catalonia, Spain. FAU - Fabregat-Sanjuan, Albert AU - Fabregat-Sanjuan A AD - Clinical and Epidemiological Neuroscience (NeuroEpia), Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Catalonia, 43204, Spain. AD - Departament d'Enginyeria Mecanica, Universitat Rovira i Virgili, Tarragona, Spain. FAU - Fernandez-Barres, Silvia AU - Fernandez-Barres S AD - Barcelona Institute for Global Health (ISGlobal) - Campus MAR, PRBB, Barcelona, Catalonia, Spain. AD - Agencia de Salut Publica de Barcelona, Barcelona, Spain. FAU - Romaguera, Dora AU - Romaguera D AD - Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain. AD - CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Madrid, Spain. FAU - Guxens, Monica AU - Guxens M AD - Barcelona Institute for Global Health (ISGlobal) - Campus MAR, PRBB, Barcelona, Catalonia, Spain. AD - Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, 28029, Spain. AD - Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Rotterdam, Netherlands. AD - ICREA, Barcelona, Spain. FAU - Julvez, Jordi AU - Julvez J AUID- ORCID: 0000-0003-0818-4003 AD - Clinical and Epidemiological Neuroscience (NeuroEpia), Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Catalonia, 43204, Spain. jordi.julvez@iispv.cat. AD - Barcelona Institute for Global Health (ISGlobal) - Campus MAR, PRBB, Barcelona, Catalonia, Spain. jordi.julvez@iispv.cat. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, 28029, Spain. jordi.julvez@iispv.cat. AD - Facultat de Medicina i Ciencies de la Salut, Human Nutrition Unit, Universitat Rovira i Virgili, Reus, Spain. jordi.julvez@iispv.cat. LA - eng PT - Journal Article DEP - 20250610 PL - Germany TA - Eur Child Adolesc Psychiatry JT - European child & adolescent psychiatry JID - 9212296 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Child MH - Animals MH - *Decision Making MH - Male MH - *Impulsive Behavior/physiology MH - *Nuts MH - *Fishes MH - *Seafood MH - *Risk-Taking MH - Adult MH - *Diet MH - *Prenatal Exposure Delayed Effects MH - *Child Behavior MH - Cohort Studies PMC - PMC12647295 OTO - NOTNLM OT - Children OT - Decision-making OT - Fish OT - Impulsivity OT - Nuts OT - Pregnancy OT - Risk COIS- Declarations. Ethics approval: Ethical approval for data collection and analysis for the INMA project was obtained from the Municipal Institute of Medical Research (No 2005/2106/I). Consent to participate: Parental written informed consent was obtained for all participants. Competing interests: The authors declare no competing interests. EDAT- 2025/06/10 13:27 MHDA- 2025/11/25 13:55 PMCR- 2025/06/10 CRDT- 2025/06/10 11:05 PHST- 2024/09/04 00:00 [received] PHST- 2025/05/10 00:00 [accepted] PHST- 2025/11/25 13:55 [medline] PHST- 2025/06/10 13:27 [pubmed] PHST- 2025/06/10 11:05 [entrez] PHST- 2025/06/10 00:00 [pmc-release] AID - 10.1007/s00787-025-02750-5 [pii] AID - 2750 [pii] AID - 10.1007/s00787-025-02750-5 [doi] PST - ppublish SO - Eur Child Adolesc Psychiatry. 2025 Nov;34(11):3643-3654. doi: 10.1007/s00787-025-02750-5. Epub 2025 Jun 10. PMID- 40490683 OWN - NLM STAT- MEDLINE DCOM- 20250609 LR - 20250609 IS - 1365-2214 (Electronic) IS - 0305-1862 (Linking) VI - 51 IP - 4 DP - 2025 Jul TI - Reliability and Construct Validity of the Self-Report Version of Strengths and Difficulties Questionnaire in Children and Adolescents With Cerebral Palsy. PG - e70114 LID - 10.1111/cch.70114 [doi] AB - BACKGROUND: Children and adolescents with childhood-onset physical disabilities, including cerebral palsy (CP), face a significantly higher risk of developing mental health disorders due to factors such as reduced physical activity, participation limitations, sleep disturbances, pain, social isolation, rejection, bullying and victimization. Therefore, identifying mental health problems in this population is crucial for promoting their mental health and psychosocial well-being. This study aimed to investigate the reliability and construct validity of the self-report Strengths and Difficulties Questionnaire (SDQ) in children and adolescents with CP. METHODS: The study included 120 children and adolescents with CP (mean age = 14.13 +/- 2.2 years), representing the full spectrum of CP subtypes. Internal consistency was assessed using McDonald's omega (omega). Test-retest reliability was assessed using intraclass correlation coefficients (ICC) to estimate the level of consistency in scores for 50 children and adolescents who completed the SDQ again after 14 days. Three types of construct validity were assessed: factorial, convergent and known-group validity. Factorial validity was assessed based on the model fit of structural equation model-based confirmatory factor analysis (CFA). For CFA, the following fit indices were considered acceptable: a Root Mean Square Error of Approximation (RMSEA) < 0.08, a Goodness of Fit Index (GFI) >/= 0.95 and a Standardized Root Mean Square Residual (SRMR) /=4 objective binge episodes/month), and no differences in BMI, indicating functionally distinct expressions of BE, beyond clinical severity and diagnostic classification. This study is the first to explore the mechanistic heterogeneity of BE through a comprehensive multi-modal assessment across three neurofunctional domains in a single sample. Findings highlight the need for updated models of BE etiology that integrate approach/reward-related behaviors, impulsivity and overcontrolled behaviors, and negative emotionality, and suggest the potential of these functionally-derived subtypes to inform the development of personalized, targeted interventions. CI - (c) 2025. The Author(s). FAU - Brucar, Leyla R AU - Brucar LR AUID- ORCID: 0000-0002-5852-3088 AD - Department of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA. FAU - Rawls, Eric AU - Rawls E AUID- ORCID: 0000-0002-4852-9961 AD - Department of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA. AD - Department of Psychology, University of North Carolina Wilmington, Wilmington, NC, USA. FAU - Haynos, Ann F AU - Haynos AF AD - Department of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA. AD - Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA. AD - Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA. FAU - Peterson, Carol B AU - Peterson CB AD - Department of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA. FAU - Zilverstand, Anna AU - Zilverstand A AUID- ORCID: 0000-0002-4889-9700 AD - Department of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA. annaz@umn.edu. AD - Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN, USA. annaz@umn.edu. LA - eng GR - RO1AA029406/U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA)/ PT - Journal Article DEP - 20250606 PL - United States TA - Transl Psychiatry JT - Translational psychiatry JID - 101562664 SB - IM MH - Humans MH - Female MH - Adult MH - Male MH - *Executive Function/physiology MH - Middle Aged MH - Young Adult MH - Adolescent MH - *Binge-Eating Disorder/physiopathology/psychology/classification MH - Magnetic Resonance Imaging MH - *Emotions/physiology MH - *Bulimia/physiopathology/psychology/classification MH - Brain/physiopathology/diagnostic imaging MH - Impulsive Behavior PMC - PMC12144091 COIS- Ethics approval and consent to participate: This study was approved by the Nathan Kline Institute Institutional Review Board in accordance with the Declaration of Helsinki. Written informed consent and permission to share de-identified data were obtained from all study participants. For the present study, after data use permission was obtained, a protocol filed with the University of Minnesota Institutional Review Board met criteria for exemption (STUDY00007003, initial approval 06-27-2019). Competing interests: The authors declare no competing interests. EDAT- 2025/06/07 16:45 MHDA- 2025/06/07 16:46 PMCR- 2025/06/06 CRDT- 2025/06/06 23:14 PHST- 2024/12/21 00:00 [received] PHST- 2025/05/21 00:00 [accepted] PHST- 2025/05/07 00:00 [revised] PHST- 2025/06/07 16:46 [medline] PHST- 2025/06/07 16:45 [pubmed] PHST- 2025/06/06 23:14 [entrez] PHST- 2025/06/06 00:00 [pmc-release] AID - 10.1038/s41398-025-03408-1 [pii] AID - 3408 [pii] AID - 10.1038/s41398-025-03408-1 [doi] PST - epublish SO - Transl Psychiatry. 2025 Jun 6;15(1):193. doi: 10.1038/s41398-025-03408-1. PMID- 40480304 OWN - NLM STAT- MEDLINE DCOM- 20250724 LR - 20260705 IS - 1878-5476 (Electronic) IS - 1878-5476 (Linking) VI - 80 DP - 2025 Sep TI - Acute and chronic effects of guidelines-based progressive resistance exercise training compared to a low-intensity sham attention-control on signs and symptoms among young adult women with analogue generalized anxiety disorder: Design and methods of a randomized controlled trial. PG - 102902 LID - S1469-0292(25)00101-3 [pii] LID - 10.1016/j.psychsport.2025.102902 [doi] AB - BACKGROUND: Recent evidence supports the positive effects of moderate-to-high-intensity, guidelines-based, progressive resistance exercise training (PRET) compared to waitlist controls among young adults with analogue Generalized Anxiety Disorder (AGAD). The true effects of PRET independent of potential social and psychological benefits of intervention engagement remain unclear. This 10-week randomized controlled trial (RCT) controls for such benefits by quantifying the acute and chronic effects of eight weeks of PRET compared to a low-intensity sham attention-control (SHAM) on GAD symptoms among young women (18-40y) with AGAD. METHODS: The full design and methods of this 10-week RCT are presented herein. Validated cut-scores on both the Psychiatric Diagnostic Screening Questionnaire GAD subscale (>/=6) and the Penn State Worry Questionnaire (>/=45) determined AGAD status. PRET was consistent with World Health Organisation and American College of Sports Medicine guidelines; participants performed two sets of 8-12 repetitions of eight exercises at 70-80 % one-repetition maximum (1RM). SHAM (20 % 1RM) was matched on all intervention features aside from load/intensity. AGAD status and worry severity (primary outcomes) were assessed at baseline, post-two-week familiarization, week 4, week 8, and one-month follow-up. Secondary outcomes were assessed weekly. Two acute resistance exercise trials were nested at weeks one and eight to quantify acute response and potential training-induced changes in acute response. CONCLUSION: This 10-week RCT advances knowledge by anticipated replication of the effects of guidelines-based PRET among young women with AGAD, investigation of a minimally-beneficial dose threshold (i.e., low-intensity SHAM) and dose-response, and control of plausible social and psychological influences of intervention engagement. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - O'Sullivan, Darragh AU - O'Sullivan D AD - Department of Physical Education and Sport Sciences, University of Limerick, Limerick, Ireland; Physical Activity for Health Research Centre, University of Limerick, Limerick, Ireland; Health Research Institute, University of Limerick, Limerick, Ireland. Electronic address: Darragh.OSullivan@ul.ie. FAU - Rice, Jennifer M AU - Rice JM AD - Department of Physical Education and Sport Sciences, University of Limerick, Limerick, Ireland; Physical Activity for Health Research Centre, University of Limerick, Limerick, Ireland; Health Research Institute, University of Limerick, Limerick, Ireland. Electronic address: Jennifer.Rice@ul.ie. FAU - Lyons, Mark AU - Lyons M AD - Department of Physical Education and Sport Sciences, University of Limerick, Limerick, Ireland; Health Research Institute, University of Limerick, Limerick, Ireland; Sport and Human Performance Research Centre, University of Limerick, Limerick, Ireland. FAU - Herring, Matthew P AU - Herring MP AD - Department of Physical Education and Sport Sciences, University of Limerick, Limerick, Ireland; Physical Activity for Health Research Centre, University of Limerick, Limerick, Ireland; Health Research Institute, University of Limerick, Limerick, Ireland. LA - eng GR - Non-US Government Research Support type/ PT - Clinical Trial Protocol PT - Journal Article DEP - 20250604 PL - Netherlands TA - Psychol Sport Exerc JT - Psychology of sport and exercise JID - 101088724 SB - IM MH - Humans MH - Female MH - *Resistance Training/methods MH - Adult MH - Young Adult MH - *Anxiety Disorders/therapy/psychology MH - Adolescent MH - Surveys and Questionnaires MH - Treatment Outcome MH - Generalized Anxiety Disorder MH - Randomized Controlled Trials as Topic OTO - NOTNLM OT - Female OT - Generalized anxiety disorder OT - Resistance training OT - Strength training OT - Worry COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Darragh O'Sullivan reports financial support was provided by Research Ireland. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/06/07 16:45 MHDA- 2025/07/25 00:29 CRDT- 2025/06/06 19:37 PHST- 2025/04/02 00:00 [received] PHST- 2025/05/29 00:00 [accepted] PHST- 2025/07/25 00:29 [medline] PHST- 2025/06/07 16:45 [pubmed] PHST- 2025/06/06 19:37 [entrez] AID - S1469-0292(25)00101-3 [pii] AID - 10.1016/j.psychsport.2025.102902 [doi] PST - ppublish SO - Psychol Sport Exerc. 2025 Sep;80:102902. doi: 10.1016/j.psychsport.2025.102902. Epub 2025 Jun 4. PMID- 40478864 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250609 IS - 2767-3375 (Electronic) IS - 2767-3375 (Linking) VI - 5 IP - 6 DP - 2025 TI - Comparison between self-reported and pedometer-measured physical activity in Vietnamese adolescents: A reliability and agreement study. PG - e0004725 LID - 10.1371/journal.pgph.0004725 [doi] LID - e0004725 AB - To compare the level of physical activity (PA) measured by self-reported questionnaire and pedometer in 12-year-old Vietnamese adolescents. Data was collected from March to May 2023 in two phases among 510 sixth-grade students in Ho Chi Minh City, Vietnam. The first phase involved a pilot study, which recruited 35 students from a randomly selected class to evaluate the Physical Activity Questionnaire for Older Children (PAQ-C) test-retest reliability. PA was measured twice, with seven-day intervals between assessments. The second phase was a cross-sectional study including 475 sixth-grade students to evaluate the agreement between PAQ-C scores and pedometer data. Participants wore a pedometer continuously for seven days and completed the PAQ-C at the end of the monitoring period. Sociodemographic and anthropometric data were collected. The sample of 35 students showed that PAQ-C demonstrated good internal consistency (alpha = 0.89) and test-retest reliability (ICC = 0.82). After one week, McNemar's test indicated no significant difference in activity levels between the baseline and second assessment. In the sample of 475 students, there was a substantial agreement between PAQ-C and pedometer in classifying physical activity levels (Cohen's kappa = 0.688, p < 0.001), with a strong correlation between daily step counts and PAQ-C scores (rs = 0.855, p < 0.001). PAQ-C is a reliable, cost-effective tool for school-based PA monitoring in 12-year-old Vietnamese adolescents, particularly in resource-limited settings. CI - Copyright: (c) 2025 Truong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Truong, Tram T N AU - Truong TTN AUID- ORCID: 0009-0008-1239-5384 AD - Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam. FAU - Huynh, Van-Anh N AU - Huynh VN AUID- ORCID: 0000-0003-2746-2048 AD - Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam. FAU - To, Kien G AU - To KG AUID- ORCID: 0000-0001-5038-5584 AD - Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam. LA - eng PT - Journal Article DEP - 20250606 PL - United States TA - PLOS Glob Public Health JT - PLOS global public health JID - 9918283779606676 PMC - PMC12143546 COIS- The authors have declared that no competing interests exist. EDAT- 2025/06/06 18:31 MHDA- 2025/06/06 18:32 PMCR- 2025/06/06 CRDT- 2025/06/06 13:44 PHST- 2025/02/09 00:00 [received] PHST- 2025/05/13 00:00 [accepted] PHST- 2025/06/06 18:32 [medline] PHST- 2025/06/06 18:31 [pubmed] PHST- 2025/06/06 13:44 [entrez] PHST- 2025/06/06 00:00 [pmc-release] AID - PGPH-D-25-00321 [pii] AID - 10.1371/journal.pgph.0004725 [doi] PST - epublish SO - PLOS Glob Public Health. 2025 Jun 6;5(6):e0004725. doi: 10.1371/journal.pgph.0004725. eCollection 2025. PMID- 40474864 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250607 IS - 2090-0724 (Print) IS - 2090-0732 (Electronic) IS - 2090-0724 (Linking) VI - 2025 DP - 2025 TI - Physical Activity and Overnutrition Among 8-11-Year-Old School Children in Thika Town, Kenya. PG - 1537082 LID - 10.1155/jnme/1537082 [doi] LID - 1537082 AB - Background: Childhood overnutrition is a growing public health concern in the 21st century. It is a risk factor for adult obesity and noncommunicable diseases. If no action is taken, it is estimated that 208 million boys and 175 million girls aged 5-19 years will be living with obesity by 2035. This study aimed to determine the physical activity status and prevalence of overnutrition among school-going children aged 8-11 years and further explored the associations. Methods: A cross-sectional study design was used among school-going children 8-11 years of age in Thika town, Kiambu County, Kenya. A total of 281 children were sampled. The physical activity levels were assessed using the validated physical activity questionnaire for older children. The BMI for age Z-scores (BAZ) was calculated based on weight and height measurements, and children with a BAZ score of +1 standard deviation were considered to have overnutrition. Data were analyzed using univariate, bivariate, and multivariate techniques. Logistic regression was employed to determine associations between the independent variables and the primary outcome. Results: The prevalence of overnutrition among the children was 11%. On the other hand, 22.4% of the children were underweight. Most of the children (86.5%) attended PE classes. More than half (54.8%) of the children were physically active. Physical inactivity and attending PE classes were not associated with overnutrition. Overnutrition was significantly higher among private than public school children (aOR 2.641; 95% CI = 1.013-6.887, p=0.0047). Conclusion: There is a presence of overnutrition in school children in Thika town, Kenya. The same population is also undernourished, thus demonstrating the double burden of malnutrition. Almost half of the children were physically inactive. An integrated approach to early detection, prevention, and management of malnutrition in children aged 5-19 years is needed. These findings have implications for public health interventions in preventing childhood obesity. Interventions could prioritize encouraging physical activity through school-based education, improvement of community infrastructure, and policy approaches. Multisectoral collaboration can create solutions that encourage active commutes with general obesity prevention. CI - Copyright (c) 2025 Margaret Wanjiru Mburu et al. Journal of Nutrition and Metabolism published by John Wiley & Sons Ltd. FAU - Mburu, Margaret Wanjiru AU - Mburu MW AUID- ORCID: 0000-0002-3959-2424 AD - Department of Community Health, Amref International University, Nairobi, Kenya. FAU - Masibo, Peninah Kinya AU - Masibo PK AD - Department of Community Health, Amref International University, Nairobi, Kenya. AD - Global Programs for Research and Training Affiliate of the University of California San Francisco (UCSF), San Francisco, California, USA. FAU - Makokha, Anselimo AU - Makokha A AD - School of Food and Nutrition Sciences, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya. FAU - Awandu, Shehu Shagari AU - Awandu SS AD - Department of Biological Sciences, Jaramogi Oginga Odinga University of Science and Technology (JOOUST), Bondo, Kenya. FAU - Owili, Patrick Opiyo AU - Owili PO AD - Department of Research and Related Capacity Strengthening, African Population and Health Research Centre (APHRC), Nairobi, Kenya. LA - eng PT - Journal Article DEP - 20250529 PL - United States TA - J Nutr Metab JT - Journal of nutrition and metabolism JID - 101526296 PMC - PMC12140827 OTO - NOTNLM OT - Kenya OT - obesity OT - overnutrition OT - overweight OT - physical activity OT - school children OT - undernutrition OT - urban settings COIS- The authors declare no conflicts of interest. EDAT- 2025/06/06 06:31 MHDA- 2025/06/06 06:32 PMCR- 2025/05/29 CRDT- 2025/06/06 05:03 PHST- 2024/07/16 00:00 [received] PHST- 2025/05/06 00:00 [accepted] PHST- 2025/06/06 06:32 [medline] PHST- 2025/06/06 06:31 [pubmed] PHST- 2025/06/06 05:03 [entrez] PHST- 2025/05/29 00:00 [pmc-release] AID - 10.1155/jnme/1537082 [doi] PST - epublish SO - J Nutr Metab. 2025 May 29;2025:1537082. doi: 10.1155/jnme/1537082. eCollection 2025. PMID- 40474197 OWN - NLM STAT- MEDLINE DCOM- 20250606 LR - 20250608 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 25 IP - 1 DP - 2025 Jun 5 TI - Comparative evaluation of bone mineral density in premature birth and low birth weight children by fractal analysis on panoramic radiographs. PG - 915 LID - 10.1186/s12903-025-06312-8 [doi] LID - 915 AB - BACKGROUND: Bone mineral density (BMD) is a critical indicator of skeletal health, and its assessment is particularly important in children born premature or with low birth weight (LBW), as these conditions are associated with altered bone development. The aim of this study was to compare the BMD values of premature and LBW children with those of normal term and normal birth weight children via fractal dimension (FD) analysis of panoramic radiographs. METHODS: This study included a total of 60 panoramic radiography images of children aged 6-15 years. The study group consisted of children born premature (before 37 weeks) and with low birth weight (less than 2500 g). The control group consisted of children born at normal term with normal birth weights. In addition, body mass index (BMI), maternal age at birth, and frequency and duration of incubation were recorded. FD values were measured in three mandibular regions on panoramic images. Independent t-tests and Mann-Whitney U tests were used to compare FD values between groups. The correlations between parameters were evaluated using Pearson and Spearman correlation coefficients. Statistical significance was set at P < 0.05. RESULTS: Comparison of the FD values revealed no significant differences between the study and control groups for ROI1 and ROI2 (p > 0.05). However, a statistically significant difference was detected in ROI3 (p < 0.05), with the study group exhibiting lower mean FD values (1.15 +/- 0.14) than the control group (1.22 +/- 0.08). There was no statistically significant difference in BMI values between the groups (p > 0.05). The frequency of incubation was significantly higher in the study group (50%) than in the control group (6.7%) (p < 0.05). CONCLUSION: Fractal dimension values of the trabecular structure in the dentate region of the mandible were decreased in premature birth and LBW children. Further controlled trials with larger sample sizes are required to validate and expand upon these findings. CLINICAL TRIAL NUMBER: Not applicable. CI - (c) 2025. The Author(s). FAU - Celik, Berrin AU - Celik B AUID- ORCID: 0000-0002-3602-2354 AD - Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Ankara Yildirim Beyazit University, Ankara, Turkey. berrincelik@aybu.edu.tr. FAU - Tugutlu, Esra Ceren AU - Tugutlu EC AUID- ORCID: 0000-0001-8241-1310 AD - Department of Pedodontics, Faculty of Dentistry, Ankara Yildirim Beyazit University, Ankara, Turkey. FAU - Arslan, Zeynep Betul AU - Arslan ZB AUID- ORCID: 0000-0001-8826-1958 AD - Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Ankara Yildirim Beyazit University, Ankara, Turkey. LA - eng PT - Comparative Study PT - Journal Article DEP - 20250605 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - *Radiography, Panoramic/methods MH - Child MH - *Fractals MH - Female MH - *Bone Density/physiology MH - Male MH - Adolescent MH - *Infant, Low Birth Weight/physiology MH - Mandible/diagnostic imaging MH - *Infant, Premature/physiology MH - Infant, Newborn MH - *Premature Birth MH - Case-Control Studies PMC - PMC12143029 OTO - NOTNLM OT - Bone mineral density OT - Fractal analysis OT - Low birth weight OT - Panoramic radiography OT - Premature COIS- Declarations. Ethics approval and consent to participate: Ethics approval and consent to participate procedures followed during the study were in accordance with the Helsinki Declaration, and the study was approved by the Ankara Yildirim Beyazit University Health Sciences Ethics Committee (No: 2022 - 902). Furthermore, written informed consent in the patients' native language for the use of radiographic and biological data in an anonymous manner was obtained from the parents of those children under the age of 16 who were referred to our clinic at the initial dental visit. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/06/06 00:27 MHDA- 2025/06/06 06:31 PMCR- 2025/06/05 CRDT- 2025/06/05 23:40 PHST- 2025/02/01 00:00 [received] PHST- 2025/05/30 00:00 [accepted] PHST- 2025/06/06 06:31 [medline] PHST- 2025/06/06 00:27 [pubmed] PHST- 2025/06/05 23:40 [entrez] PHST- 2025/06/05 00:00 [pmc-release] AID - 10.1186/s12903-025-06312-8 [pii] AID - 6312 [pii] AID - 10.1186/s12903-025-06312-8 [doi] PST - epublish SO - BMC Oral Health. 2025 Jun 5;25(1):915. doi: 10.1186/s12903-025-06312-8. PMID- 40474150 OWN - NLM STAT- MEDLINE DCOM- 20250606 LR - 20250609 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Jun 5 TI - Research on the capability, opportunity, and motivation of schools to conduct physical activities in China: a cross-group validation. PG - 2102 LID - 10.1186/s12889-025-23231-z [doi] LID - 2102 AB - BACKGROUND: Insufficient physical activity among adolescents is a major global public health concern, and schools are considered key venues for promoting physical activity. Teachers play a crucial role in the implementation of policies. This study adapted and validated the COM-PASS scale, based on the COM-B model, to assess its reliability and validity in the Chinese context. METHODS: This study validates the appropriateness of the COM-PASS scale based on the COM-B model, assessing its reliability and validity within the Chinese cultural context. A three-phase design was employed: (1) A Delphi method involving three rounds of surveys with 15 experts to refine the questionnaire's relevance and validity; (2) Cognitive interviews with 10 primary and secondary school teachers to evaluate item comprehensibility; (3) Confirmatory factor analysis of 4,033 questionnaires across China's seven major administrative regions to verify structural validity and internal consistency. RESULTS: The CFA results showed that the three-factor model fit well (chi(2) = 3179.436, df = 518, CFI = 0.964, TLI = 0.956, RMSEA = 0.036), with factor loadings for all items exceeding 0.750. The Cronbach's alpha coefficients for the three dimensions were 0.957, 0.947, and 0.965, respectively. Path coefficient tests indicated strong explanatory power of the latent variables on the observed variables (standardized path coefficients ranged from 0.781 to 0.951). Cross-group validation demonstrated the scale's stability and applicability across different administrative regions in China. CONCLUSION: The Chinese version of the COM-PASS scale has shown good reliability and validity among the population of Chinese primary and secondary school teachers, and it can effectively assess main factors affecting the development of school physical education activities. The results provide a targeted scientific basis for optimizing school physical education policies, addressing regional resource differences, and teacher training strategies. The scale demonstrates strong cultural applicability and provides practical guidance for enhancing the 'Double Reduction' policy and advancing school-based physical education activities across China. CI - (c) 2025. The Author(s). FAU - Wu, Jingtao AU - Wu J AD - School of Physical Education, Leshan Normal University, Leshan, China. FAU - Yang, Yi AU - Yang Y AD - Humanities and Law School, Chengdu University of Technology, No.1 Dong 3 Road, Chengdu District, 610056, Sichuan Province, China. 476199815@qq.com. FAU - Shao, Yanhong AU - Shao Y AD - Xiangshui Teacher Development Center, Yancheng, China. FAU - Zhang, Xiaolin AU - Zhang X AD - School of Physical Education, Sichuan Normal University, Chengdu, China. FAU - Zang, Wanli AU - Zang W AD - Postgraduate School, Harbin Sport University, Harbin, China. FAU - Hu, Jun AU - Hu J AD - School of Physical Education, Leshan Normal University, Leshan, China. LA - eng GR - Grant No. BLA240185/National Social Science Fund for Educational Research/ GR - Grant No. BLA240185/National Social Science Fund for Educational Research/ GR - Grant No. BLA240185/National Social Science Fund for Educational Research/ PT - Journal Article PT - Validation Study DEP - 20250605 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - China MH - Surveys and Questionnaires/standards MH - Female MH - Male MH - *Exercise/psychology MH - Reproducibility of Results MH - *Schools MH - *Motivation MH - Delphi Technique MH - *School Teachers/psychology MH - Adolescent MH - Factor Analysis, Statistical MH - Psychometrics MH - Adult PMC - PMC12139187 OTO - NOTNLM OT - COM-B model OT - COM-PASS scale OT - Capability OT - Confirmatory factor analysis OT - Motivation OT - Opportunity OT - School sports OT - Teacher behavior COIS- Declarations. Ethics approval and consent to participate: This research has been approved by the Ethics Committee of the Academic Committee of Leshan Normal University (Approval number: LSNU: 103324-RO). We strictly adhered to the Helsinki Declaration and relevant ethical guidelines in China to ensure the protection of participants'life, health, privacy, and dignity. Informed consent: Prior to data collection, the research team provided detailed explanations of the study's purpose, methods, risks, and benefits to the management, teachers, and parents of all participating schools. All student participants obtained informed consent from their parents or guardians, ensuring voluntary participation with full understanding. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/06/06 00:27 MHDA- 2025/06/06 06:29 PMCR- 2025/06/05 CRDT- 2025/06/05 23:38 PHST- 2025/02/03 00:00 [received] PHST- 2025/05/19 00:00 [accepted] PHST- 2025/06/06 06:29 [medline] PHST- 2025/06/06 00:27 [pubmed] PHST- 2025/06/05 23:38 [entrez] PHST- 2025/06/05 00:00 [pmc-release] AID - 10.1186/s12889-025-23231-z [pii] AID - 23231 [pii] AID - 10.1186/s12889-025-23231-z [doi] PST - epublish SO - BMC Public Health. 2025 Jun 5;25(1):2102. doi: 10.1186/s12889-025-23231-z. PMID- 40469650 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250607 IS - 2159-2896 (Print) IS - 2159-2896 (Electronic) IS - 2159-2896 (Linking) VI - 20 IP - 6 DP - 2025 TI - Maximal Strength Testing Using the Long-Lever Hip Adduction Squeeze Test in Youth Elite Football (Soccer) Players: A Four-Week Reliability Study. PG - 824-831 LID - 10.26603/001c.138472 [doi] AB - INTRODUCTION: The long-lever hip adduction squeeze test is a feasible and quick way to measure maximal hip adduction strength, which is associated with groin injury risk. Excellent week-to-week reliability has been established in senior elite football. Youth elite players often engage in physical activities outside of the football academy, which may affect reliability. This study aimed to investigate the week-to-week reliability of the long-lever hip adduction squeeze strength in a youth elite academy football setting using a novel groin strength testing device. MATERIALS AND METHODS: Seventy-nine youth elite male football players from the U13 to U19 teams of a youth elite football academy were included. During four consecutive weeks, players were tested weekly at the same day each week (match day +2), using a long-lever hip adduction squeeze device with maximal strength recorded. Players who reported groin pain of >2 out of 10 during testing were excluded. RESULTS: No systematic bias was observed between the different testing weeks (p>0.5). Good and consistent relative week-to-week reliability was observed (ICC: 0.916-0.933). Absolute reliability (SEM %) ranged from 7.6-8.6%, with MDCind % and MDCgroup % ranging from 21.2-24 % and 3.3-5.8 %, respectively. CONCLUSION: Week-to-week measures of long-lever hip adduction strength showed good relative and absolute reliability, and thus can be used in the academy setting to reliably screen for groin injury risk. CI - (c) The Author(s). FAU - Ishoi, Lasse AU - Ishoi L AD - Human Performance Department, Right to Dream, Farum, Denmark. AD - Sports Orthopedic Research Center - Copenhagen (SORC-C), Department of Orthopedic Surgery, Hvidovre Hospital, Copenhagen, Denmark. FAU - Petersen, Jonas AU - Petersen J AD - Human Performance Department, Right to Dream, Farum, Denmark. FAU - Thornton, Kasper AU - Thornton K AD - Human Performance Department, Right to Dream, Farum, Denmark. FAU - DeLang, Matthew AU - DeLang M AD - Human Performance Department, Right to Dream, Farum, Denmark. LA - eng PT - Journal Article DEP - 20250601 PL - United States TA - Int J Sports Phys Ther JT - International journal of sports physical therapy JID - 101553140 PMC - PMC12129639 OTO - NOTNLM OT - Adductor Squeeze OT - Early Detection OT - Groin OT - Injury Prevention OT - Reliability OT - Youth Elite Athletes COIS- The authors report no financial conflicts of interest, but LI and MDD have offered feedback in the development of the testing device used in the present study. EDAT- 2025/06/05 06:28 MHDA- 2025/06/05 06:29 PMCR- 2025/06/01 CRDT- 2025/06/05 05:21 PHST- 2024/12/13 00:00 [received] PHST- 2025/04/23 00:00 [accepted] PHST- 2025/06/05 06:29 [medline] PHST- 2025/06/05 06:28 [pubmed] PHST- 2025/06/05 05:21 [entrez] PHST- 2025/06/01 00:00 [pmc-release] AID - 138472 [pii] AID - 10.26603/001c.138472 [doi] PST - epublish SO - Int J Sports Phys Ther. 2025 Jun 1;20(6):824-831. doi: 10.26603/001c.138472. eCollection 2025. PMID- 40469594 OWN - NLM STAT- MEDLINE DCOM- 20250605 LR - 20250607 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Social media use and negative body image perception in Saudi Arabian women. PG - 1447563 LID - 10.3389/fpubh.2025.1447563 [doi] LID - 1447563 AB - BACKGROUND: Social media has become deeply embedded in daily life, particularly among females who spend significant time on visual-based platforms such as Snapchat, and Instagram. Exposure to unrealistic beauty standards on these platforms has been linked to negative body image, a growing global public health concern with well-documented psychological and behavioral consequences. While this relationship has been widely studied globally, research within Saudi Arabia, especially among adult women beyond early adulthood, remains limited. OBJECTIVE: This study aimed to examine the association between social media use and body image perception among adult females in Saudi Arabia, while accounting for relevant factors such as sociodemographic characteristics, BMI, and beauty filter use. METHODS: An online cross-sectional survey was conducted among adult females (aged >/= 18) in Saudi Arabia. Validated instruments-the Social Media Addiction Scale-14 and the Body Image Questionnaire-were used to assess social media addiction and negative body image, respectively. Associations were examined using Poisson regression with robust variance. RESULTS: Of the 1,136 participants, 71.2% were classified as having a negative body image. Participants with social media addiction severity and BMI outside the normal range (underweight, overweight, or obese) had significantly higher rates of negative body image (p < 0.001). In contrast, using beauty filters showed no significant association with negative body image. CONCLUSION: Negative body image is highly prevalent among adult females in Saudi Arabia and is significantly associated with both social media and higher body mass index. These findings highlight the need for culturally appropriate interventions to improve body acceptance. CI - Copyright (c) 2025 AlQahtani, Shaikh, Ahmad and Alhusseini. FAU - AlQahtani, Maha AU - AlQahtani M AD - Biostatistics, Epidemiology and Public Health, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. AD - Research Department, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. FAU - Shaikh, Narmeen AU - Shaikh N AD - Biostatistics, Epidemiology and Public Health, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. FAU - Ahmad, Khabir AU - Ahmad K AD - Research Department, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. FAU - Alhusseini, Noara AU - Alhusseini N AD - Biostatistics, Epidemiology and Public Health, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. LA - eng PT - Journal Article DEP - 20250521 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Female MH - *Social Media/statistics & numerical data MH - *Body Image/psychology MH - Adult MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - Body Mass Index MH - Middle Aged MH - Young Adult MH - Adolescent PMC - PMC12133476 OTO - NOTNLM OT - BMI OT - Saudi Arabia OT - adult females OT - beauty filters OT - digital health OT - negative body image OT - social media addiction COIS- The authors declare that the research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/06/05 06:28 MHDA- 2025/06/05 06:29 PMCR- 2025/05/21 CRDT- 2025/06/05 05:20 PHST- 2024/06/11 00:00 [received] PHST- 2025/04/28 00:00 [accepted] PHST- 2025/06/05 06:29 [medline] PHST- 2025/06/05 06:28 [pubmed] PHST- 2025/06/05 05:20 [entrez] PHST- 2025/05/21 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1447563 [doi] PST - epublish SO - Front Public Health. 2025 May 21;13:1447563. doi: 10.3389/fpubh.2025.1447563. eCollection 2025. PMID- 40468454 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250609 IS - 2055-0928 (Electronic) IS - 2055-0928 (Linking) VI - 11 IP - 1 DP - 2025 Jun 4 TI - Association of sociodemographic factors and television food advertisements with junk food consumption among a sample of adolescents aged 13 to 17 in Magura district, Bangladesh: a cross-sectional survey. PG - 109 LID - 10.1186/s40795-025-01101-6 [doi] LID - 109 AB - OBJECTIVES: The aim of this study was to examine the association of sociodemographic factors and television advertisements with junk food consumption among adolescents aged 13 to 17 in Bangladesh. METHODS: This cross-sectional study included 326 adolescent-parent pairs from secondary education establishments at Magura municipal areas of Bangladesh. A validated structured survey questionnaire was utilized. Socio-demographic details, junk consumption frequency and types of information sought from food packages were asked from the adolescents. The outcome of this study was assessed using a single question ( 3 times): How many times a week do you usually eat junk foods? Parents' concerns about the television advertisements for children' food products also assessed. Multinomial logistic regression analysis was applied. RESULTS: Almost half of the participated adolescents (48.16%) reported they consumed junk food > 3 times a week. Our study found that adolescent boys [Odds ratio, OR (adjusted)=3.45; 95% confidence interval, CI = 1.60, 7.43] and those who studied in class eight [OR (adjusted)=5.78; 95% CI = 1.33, 25.17] had a higher probability of consuming junk food > 3 times a week compared to their respective counterparts. Participants whose mothers had tertiary education were less likely to consume junk food > 3 times [OR (adjusted)=0.28; 95%CI = 0.02, 0.23] a week than their counterparts. Additionally, adolescents' junk food consumption frequency was significantly associated with their parental concern regarding the timing of television advertisements and the advertisements of unhealthy food products when children watch television. CONCLUSION: Several sociodemographic factors, such as adolescent's gender, study class, mother's education and occupation, and parental concerns regarding television advertisements were found to be associated with increased junk food consumption frequency. Policymakers and nutrition experts may use these data to modify food labelling and television commercial rules in order to develop family-oriented interventions to improve diet quality and health indicators. CI - (c) 2025. The Author(s). FAU - Akter, Shammy AU - Akter S AD - Department of Applied Nutrition and Food Technology, Faculty of Biological Sciences, Islamic University, Kushtia, Bangladesh. FAU - Al Banna, Md Hasan AU - Al Banna MH AD - Department of Food Microbiology, Faculty of Nutrition and Food Science, Patuakhali Science and Technology University, Patuakhali, Bangladesh. banna.nfs.pstu@gmail.com. FAU - Tetteh, Justice Kanor AU - Tetteh JK AD - Department of Population and Health, University of Cape Coast, University Post Office, Cape Coast, Ghana. FAU - Mallick, Trisha AU - Mallick T AD - Department of Environmental Sanitation, Faculty of Nutrition and Food Science, Patuakhali Science and Technology University, Patuakhali, Bangladesh. FAU - Azhar, Bably Sabina AU - Azhar BS AD - Department of Applied Nutrition and Food Technology, Faculty of Biological Sciences, Islamic University, Kushtia, Bangladesh. FAU - Nahar, Joytun AU - Nahar J AD - Department of Applied Nutrition and Food Technology, Faculty of Biological Sciences, Islamic University, Kushtia, Bangladesh. FAU - Chowdhury, Masuma AU - Chowdhury M AD - Department of Applied Nutrition and Food Technology, Faculty of Biological Sciences, Islamic University, Kushtia, Bangladesh. FAU - Wilfred, Addah Graham Gilbert AU - Wilfred AGG AD - Department of Nursing, University of Energy and Natural Resources, Sunyani, Ghana. FAU - Sahrin, Sumaia AU - Sahrin S AD - Department of Human Nutrition and Dietetics, Faculty of Nutrition and Food Science, Patuakhali Science and Technology University, Patuakhali, Bangladesh. LA - eng PT - Journal Article DEP - 20250604 PL - England TA - BMC Nutr JT - BMC nutrition JID - 101672434 PMC - PMC12135569 OTO - NOTNLM OT - Adolescents OT - Bangladesh OT - Eating habits OT - Junk food OT - Television advertisements COIS- Declarations. Ethics approval and consent to participate: The Institutional Ethical Committee (IEC) of Patuakhali Science and Technology University, Bangladesh reviewed and approved the study protocol [PSTU/IEC/2023/50]. All study procedures were carried out in accordance with relevant guidelines and regulations. The participation was voluntary and written informed consent was obtained from all participants. Consent was also obtained from the parents of all participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/06/05 00:28 MHDA- 2025/06/05 00:29 PMCR- 2025/06/04 CRDT- 2025/06/04 23:54 PHST- 2024/06/20 00:00 [received] PHST- 2025/05/27 00:00 [accepted] PHST- 2025/06/05 00:29 [medline] PHST- 2025/06/05 00:28 [pubmed] PHST- 2025/06/04 23:54 [entrez] PHST- 2025/06/04 00:00 [pmc-release] AID - 10.1186/s40795-025-01101-6 [pii] AID - 1101 [pii] AID - 10.1186/s40795-025-01101-6 [doi] PST - epublish SO - BMC Nutr. 2025 Jun 4;11(1):109. doi: 10.1186/s40795-025-01101-6. PMID- 40466001 OWN - NLM STAT- MEDLINE DCOM- 20250604 LR - 20250609 IS - 1806-9282 (Electronic) IS - 0104-4230 (Print) IS - 0104-4230 (Linking) VI - 71 IP - 4 DP - 2025 TI - Exploring the structural and construct validity of the Brazilian version of the Eating Pathology Symptoms Inventory. PG - e20241894 LID - S0104-42302025000400616 [pii] LID - 10.1590/1806-9282.20241894 [doi] LID - e20241894 AB - OBJECTIVE: The aim of this study was to evaluate the psychometric properties of the Eating Pathology Symptoms Inventory within the Brazilian context. Specifically, it assessed the scale's efficacy in measuring disordered eating behaviors, with an emphasis on binge eating, and investigated its relationship with food cravings. METHODS: This cross-sectional study utilized data from a non-probabilistic convenience sample of 1,374 Brazilians. Confirmatory factor analysis and multiple-group confirmatory factor analysis were employed to examine the factor structure and assess invariance across groups with and without binge-eating symptoms. Reliability was evaluated using Cronbach's alpha and McDonald's omega, while external validity was assessed through Pearson's correlations between Eating Pathology Symptoms Inventory and Food Cravings Questionnaire-Trait-reduced scores. Discriminant validity was analyzed using Welch's t-test. RESULTS: The confirmatory factor analysis supported the eight-factor model, demonstrating a good fit across the overall sample (Comparative Fit Index=0.936, root mean square error of approximation=0.057). Reliability analysis indicated high internal consistency, with Cronbach's alpha and McDonald's omega values ranging from 0.745 to 0.917. Multiple-group confirmatory factor analysis confirmed measurement invariance across groups with and without binge-eating symptoms. The Welch two-sample t-test showed significantly higher Eating Pathology Symptoms Inventory scores in the binge-eating group. Furthermore, Eating Pathology Symptoms Inventory subscales related to binge-eating behaviors exhibited strong correlations with food craving scores, supporting the scale's external validity. CONCLUSION: The Eating Pathology Symptoms Inventory demonstrates strong reliability and validity as a tool for assessing eating disorder symptoms in Brazil, with effectiveness in distinguishing binge-eating behaviors. FAU - Lessa, Joao Paulo AU - Lessa JP AUID- ORCID: 0000-0003-0751-7662 AD - Universidade Tuiuti do Parana, Graduate Program in Forensic Psychology - Curitiba (PR), Brazil. AD - Institute for Research on Behavior and Food - Curitiba (PR), Brazil. FAU - Colombarolli, Maira Stivaleti AU - Colombarolli MS AUID- ORCID: 0000-0002-2551-2593 AD - Universidade de Sao Paulo, Faculty of Philosophy, Sciences and Letters of Ribeirao Preto - Ribeirao Preto (SP), Brazil. FAU - Oliveira, Jonatas de AU - Oliveira J AUID- ORCID: 0000-0003-2110-5920 AD - Institute for Research on Behavior and Food - Curitiba (PR), Brazil. AD - Universidade de Sao Paulo, School of Medicine, Faculty of Medicine - Sao Paulo (SP), Brazil. LA - eng PT - Journal Article PT - Validation Study DEP - 20250602 PL - Brazil TA - Rev Assoc Med Bras (1992) JT - Revista da Associacao Medica Brasileira (1992) JID - 9308586 SB - IM MH - Humans MH - Brazil MH - Female MH - Reproducibility of Results MH - Cross-Sectional Studies MH - Adult MH - Psychometrics MH - Male MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Surveys and Questionnaires/standards MH - Factor Analysis, Statistical MH - Young Adult MH - Adolescent MH - Middle Aged MH - Bulimia/diagnosis PMC - PMC12131885 COIS- Conflicts of interest: the authors declare there is no conflicts of interest. EDAT- 2025/06/04 18:29 MHDA- 2025/06/04 18:30 PMCR- 2025/06/02 CRDT- 2025/06/04 15:44 PHST- 2024/10/23 00:00 [received] PHST- 2025/01/05 00:00 [accepted] PHST- 2025/06/04 18:30 [medline] PHST- 2025/06/04 18:29 [pubmed] PHST- 2025/06/04 15:44 [entrez] PHST- 2025/06/02 00:00 [pmc-release] AID - S0104-42302025000400616 [pii] AID - 10.1590/1806-9282.20241894 [doi] PST - epublish SO - Rev Assoc Med Bras (1992). 2025 Jun 2;71(4):e20241894. doi: 10.1590/1806-9282.20241894. eCollection 2025. PMID- 40464046 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250606 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 13 DP - 2025 TI - Progress in research on nutrition, neuroinflammation and dopaminergic alterations in Tic disorders. PG - 1526117 LID - 10.3389/fped.2025.1526117 [doi] LID - 1526117 AB - Tic disorders (TD) represent a prevalent neurodevelopmental condition in children, characterised by involuntary, sudden motor or vocal tics. Dysfunction of the dopamine system plays a pivotal role in the pathogenesis of TD. Recent findings indicate that deep brain stimulation, by modulating striatal dopamine release, substantially alleviates tic symptoms. Neuroimaging studies have shown increased dopamine transporter binding and decreased serotonin levels in patients with TD. The presence of anti-dopamine D2 receptor autoantibodies, which correlate with disease severity, suggests immune involvement in the onset of TD. Nutritional factors influence the dopaminergic system's functionality by affecting neurotransmitter synthesis and metabolism, modulating gut microbiota and contributing to neuroinflammation. Clinical studies have demonstrated that interventions combining probiotics and fructooligosaccharides can help regulate neurotransmitter metabolism, whereas dietary patterns such as the ketogenic, Mediterranean and Mediterranean-DASH intervention for neurodegenerative delay diets exhibit anti-inflammatory and neuroprotective effects. The risk of TD in offspring is significantly associated with maternal autoimmune diseases and inflammatory states, with metabolic syndrome further affecting the dopaminergic system via AT1 receptor autoantibodies. Nutritional intervention-based treatment strategies present promising directions for TD management, warranting further investigation into the nutrition-immune-neurotransmitter network, the development of personalised nutritional plans and the validation of their clinical efficacy through large-scale randomised controlled trials. This review summarises the alterations in the dopaminergic system in TD, the regulatory effects of nutritional factors on dopamine levels, the interactions between neuroinflammation and the dopaminergic system and treatment strategies based on nutritional interventions, laying a theoretical foundation for understanding TD pathogenesis and advancing novel therapeutic approaches. CI - (c) 2025 Bai, Jin, Zhang and Sun. FAU - Bai, Lu AU - Bai L AD - Primary Child Care Department (Psychological Behavior Department), Children's Hospital of Hebei Province, Shijiazhuang City, Hebei, China. FAU - Jin, Mei AU - Jin M AD - Department of Pediatric Neurology, Children's Hospital of Hebei Province, Shijiazhuang City, Hebei, China. FAU - Zhang, Qi AU - Zhang Q AD - Department of Anesthesiology, Children's Hospital of Hebei Province, Shijiazhuang City, Hebei, China. FAU - Sun, Suzhen AU - Sun S AD - Department of Pediatric Neurology, Children's Hospital of Hebei Province, Shijiazhuang City, Hebei, China. LA - eng PT - Journal Article PT - Review DEP - 20250520 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC12130006 OTO - NOTNLM OT - Tic disorders OT - dopamine OT - neuroinflammation OT - nutrition OT - treatment COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/06/04 06:27 MHDA- 2025/06/04 06:28 PMCR- 2025/05/20 CRDT- 2025/06/04 05:10 PHST- 2024/11/11 00:00 [received] PHST- 2025/05/05 00:00 [accepted] PHST- 2025/06/04 06:28 [medline] PHST- 2025/06/04 06:27 [pubmed] PHST- 2025/06/04 05:10 [entrez] PHST- 2025/05/20 00:00 [pmc-release] AID - 10.3389/fped.2025.1526117 [doi] PST - epublish SO - Front Pediatr. 2025 May 20;13:1526117. doi: 10.3389/fped.2025.1526117. eCollection 2025. PMID- 40462657 OWN - NLM STAT- MEDLINE DCOM- 20250703 LR - 20260903 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 28 IP - 1 DP - 2025 Jun 4 TI - Validation of NOVA 27 ultra-processed food screener: adaptation and performance in Ecuador. PG - e105 LID - 10.1017/S1368980025100475 [doi] LID - e105 AB - OBJECTIVE: This study aimed to adapt and validate the NOVA 27 ultra-processed food (UPF) Screener for use in Ecuador by identifying commonly consumed foods, classifying them using the NOVA system and testing the screener's validity in an urban sample and a national food survey. DESIGN: A cross-sectional study was conducted in two phases: screener validation with a convenience sample of 327 adults in Quito through an online questionnaire (2021) and assessment of its applicability using data from the 2012 Ecuadorian National Health and Nutrition Survey (ENSANUT-Ecu). The method, adapted from a similar study in Brazil, compared NOVA UPF scores to the 24 h-Recall (24-HR) automated multiple-pass method, used as the gold standard. SETTING: The study included Quito's urban population for validation and secondary data from ENSANUT-Ecu. PARTICIPANTS: Three hundred and twenty-seven adults aged 18-64 from Quito were included in the validation phase, and 3510 adults from the ENSANUT-Ecu dataset were analysed in the secondary analysis. RESULTS: The screener adaptation identified twenty-seven subgroups of commonly consumed UPF, summarising 90 % of UPF energy intake. Validation results indicated significant agreement between the NOVA-UPF score and UPF intake, with PABAK indices above 0.8 for most socio-demographic groups. Higher NOVA-UPF scores corresponded to increased UPF dietary shares, mirroring patterns observed in the ENSANUT-Ecu dataset. CONCLUSIONS: The adapted NOVA 27 UPF Screener is a valid tool for assessing UPF intake in Ecuador, offering a practical resource for future dietary surveys to monitor and address UPF intake among Ecuadorian adults. FAU - B Freire, Wilma AU - B Freire W AD - Institute for Research in Health and Nutrition, Universidad San Francisco de Quito, Quito, Ecuador. FAU - Tello, Betzabe AU - Tello B AUID- ORCID: 0000-0001-5890-6436 AD - Center for Research on Health in Latin America (CISeAL), Facultad de Medicina, Pontificia Universidad Catolica del Ecuador, Quito, Ecuador. FAU - Belmont Guerron, Philippe AU - Belmont Guerron P AUID- ORCID: 0000-0003-2057-8873 AD - Center for Research on Health in Latin America (CISeAL), Facultad de Medicina, Pontificia Universidad Catolica del Ecuador, Quito, Ecuador. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250604 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Ecuador MH - Adult MH - Cross-Sectional Studies MH - Male MH - Female MH - Middle Aged MH - *Fast Foods/statistics & numerical data MH - Young Adult MH - Adolescent MH - Nutrition Surveys MH - *Diet/statistics & numerical data MH - Reproducibility of Results MH - *Diet Surveys/methods MH - Urban Population/statistics & numerical data MH - Surveys and Questionnaires MH - Food, Processed PMC - PMC12264781 OTO - NOTNLM OT - Diet survey OT - NOVA Food Classification OT - Questionnaire OT - Ultra-processed Foods OT - Validation study COIS- There are no conflicts of interest. EDAT- 2025/06/04 06:27 MHDA- 2025/07/03 06:28 PMCR- 2025/06/04 CRDT- 2025/06/04 03:53 PHST- 2025/07/03 06:28 [medline] PHST- 2025/06/04 06:27 [pubmed] PHST- 2025/06/04 03:53 [entrez] PHST- 2025/06/04 00:00 [pmc-release] AID - S1368980025100475 [pii] AID - 10.1017/S1368980025100475 [doi] PST - epublish SO - Public Health Nutr. 2025 Jun 4;28(1):e105. doi: 10.1017/S1368980025100475. PMID- 40462609 OWN - NLM STAT- MEDLINE DCOM- 20250904 LR - 20250904 IS - 1699-5198 (Electronic) IS - 0212-1611 (Linking) VI - 42 IP - 4 DP - 2025 Sep 4 TI - Utility of equations that consider gross motor function to estimate height in a Mexican population of children and adolescents with cerebral palsy. PG - 702-709 LID - 10.20960/nh.05651 [doi] AB - Introduction: height estimation is essential for the assessment of nutritional status. In children with cerebral palsy (CP), it is difficult to obtain this information reliably. The equations that consider gross motor function to estimate height have not been tested in the Mexican population. Objective: to evaluate the usefulness of equations that consider gross motor function to estimate height in a Mexican population of children and adolescents with CP. Methods: this was an analytical cross-sectional study of children and adolescents from two to 18 years of age with CP. Height, height-for-age index and BMI were estimated via the Stevenson and Ruiz-Brunner equations. The Mann-Whitney U-test, Spearman correlation and Bland-Altman concordance analysis were performed. Results: the equations that consider gross motor function showed excellent correlations (height r = 0.987, p < 0.001; height-for-age index r = 0.959, p < 0.001; and BMI r = 0.986, p < 0.001). The mean difference for height was -2.92 +/- 3.14 cm; for the height-for-age index, it was -2.67 +/- 2.66 %; and for BMI, it was 0.75 +/- 0.71 kg/m2. The groups with levels 1-3 gross motor function showed wider limits of agreement than groups with levels 4-5 for the three anthropometric indicators. Conclusion: the equations that consider the levels of gross motor function to estimate height are useful in a Mexican population with CP. FAU - Garcia-Contreras, Andrea Anais AU - Garcia-Contreras AA AD - Instituto de Nutricion Humana. Centro Universitario de Ciencias de la Salud. Universidad de Guadalajara. Escuela de Medicina y Ciencias de la Salud. Instituto Tecnologico y de Estudios Superiores de Monterrey. FAU - Garcia-Iniguez, Jorge Abraham AU - Garcia-Iniguez JA AD - Escuela de Nutricion. Universidad Autonoma de Guadalajara. FAU - Camacho-Buenrostro, Dennis AU - Camacho-Buenrostro D AD - Facultad de Medicina. Universidad de Colima. FAU - Vasquez-Garibay, Edgar Manuel AU - Vasquez-Garibay EM AD - Instituto de Nutricion Humana. Centro Universitario de Ciencias de la Salud. Universidad de Guadalajara. FAU - Martinez Romero, Luisa Fernanda AU - Martinez Romero LF AD - Escuela de Medicina y Ciencias de la Salud. Instituto Tecnologico y de Estudios Superiores de Monterrey. FAU - Mujica-Paez, Jimena AU - Mujica-Paez J AD - Escuela de Medicina y Ciencias de la Salud. Instituto Tecnologico y de Estudios Superiores de Monterrey. FAU - Murrieta-Verduzco, Andrea Maria AU - Murrieta-Verduzco AM AD - Escuela de Medicina y Ciencias de la Salud. Instituto Tecnologico y de Estudios Superiores de Monterrey. FAU - Rojas-Chavez, Ana Paula AU - Rojas-Chavez AP AD - Escuela de Medicina y Ciencias de la Salud. Instituto Tecnologico y de Estudios Superiores de Monterrey. LA - eng PT - Journal Article TT - Utilidad de las ecuaciones que consideran la funcion motora gruesa para estimar la talla en una poblacion mexicana de ninos y adolescentes con paralisis cerebral. PL - Spain TA - Nutr Hosp JT - Nutricion hospitalaria JID - 9100365 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology MH - Child MH - Adolescent MH - *Body Height MH - Mexico/epidemiology MH - Cross-Sectional Studies MH - Male MH - Female MH - Child, Preschool MH - Body Mass Index MH - Anthropometry/methods MH - *Motor Skills/physiology OTO - NOTNLM OT - Paralisis cerebral. Talla. Indice de masa corporal. Ninos. Adolescentes. EDAT- 2025/06/04 06:27 MHDA- 2025/09/04 12:38 CRDT- 2025/06/04 03:23 PHST- 2025/09/04 12:38 [medline] PHST- 2025/06/04 06:27 [pubmed] PHST- 2025/06/04 03:23 [entrez] AID - 10.20960/nh.05651 [doi] PST - ppublish SO - Nutr Hosp. 2025 Sep 4;42(4):702-709. doi: 10.20960/nh.05651. PMID- 40462589 OWN - NLM STAT- MEDLINE DCOM- 20250703 LR - 20260903 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 28 IP - 1 DP - 2025 Jun 4 TI - Development and psychometric properties of a questionnaire on adolescents' home food environment. PG - e107 LID - 10.1017/S1368980025100402 [doi] LID - e107 AB - OBJECTIVE: To describe the design and psychometric assessment of the Adolescent Home Food Environment Questionnaire (Acronym in Portuguese: QAAD). DESIGN: This was a cross-sectional study. Data were collected between August 2021 and January 2022 through self-administered questionnaires via a survey management application accessible by computer or smartphone. The instrument was subjected to analysis by a panel of experts and to a pretest that enabled the adjustment of the language and the reformulation of the questions. The psychometric evaluation included the assessment of test-retest reliability (intraclass correlation coefficient), internal consistency (composite reliability), structural validity (exploratory structural equation modelling and confirmatory factor analysis) and construct validity (Mann‒Whitney test; P< 0.05). The following food environment aspects were evaluated: family eating practices, food availability and accessibility, cooking equipment availability and parental feeding style. Moreover, the weekly frequency of fruit, bean and added sugar beverage consumption was assessed. SETTING: A public high school in Rio de Janeiro, Brazil. PARTICIPANTS: 14-to-19-year-old students (n 34 in the test‒retest reliability study; n 501 in the validation analysis). RESULTS: The final version of the QAAD included thirty-two questions allowing the assessment of seven dimensions of the home food environment. The QAAD demonstrated satisfactory reliability (ICC ranging from 0.44 to 0.78), adequate internal consistency (composite reliability > 0.70) and satisfactory structural and construct validity. CONCLUSIONS: The careful QAAD design provided a valid, reliable and consistent instrument for characterising adolescents' home food environments, which may provide information for tailoring and targeting healthy eating promotion actions aimed at adolescents. FAU - Batista Rodrigues, Camila AU - Batista Rodrigues C AUID- ORCID: 0000-0002-1891-0534 AD - Graduate Program in Nutrition, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Souza Marques, Emanuele AU - Souza Marques E AD - Institute of Social Medicine, Rio de Janeiro State University, Rio de Janeiro, Brazil. FAU - Alves Pereira, Rosangela AU - Alves Pereira R AD - Department of Social and Applied Nutrition, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. LA - eng PT - Journal Article DEP - 20250604 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Adolescent MH - *Psychometrics MH - Female MH - Male MH - Cross-Sectional Studies MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - Brazil MH - Young Adult MH - *Home Environment MH - *Feeding Behavior/psychology MH - *Diet/statistics & numerical data PMC - PMC12264776 OTO - NOTNLM OT - Adolescent OT - Food OT - Home environment OT - Surveys and questionnaires OT - Validation study COIS- There are no conflicts of interest. EDAT- 2025/06/04 06:27 MHDA- 2025/07/03 06:27 PMCR- 2025/06/04 CRDT- 2025/06/04 03:13 PHST- 2025/07/03 06:27 [medline] PHST- 2025/06/04 06:27 [pubmed] PHST- 2025/06/04 03:13 [entrez] PHST- 2025/06/04 00:00 [pmc-release] AID - S1368980025100402 [pii] AID - 10.1017/S1368980025100402 [doi] PST - epublish SO - Public Health Nutr. 2025 Jun 4;28(1):e107. doi: 10.1017/S1368980025100402. PMID- 40462190 OWN - NLM STAT- MEDLINE DCOM- 20250604 LR - 20250626 IS - 1745-6215 (Electronic) IS - 1745-6215 (Linking) VI - 26 IP - 1 DP - 2025 Jun 3 TI - MindRegulation-SEL: randomized controlled trial of the effects of a relaxation and guided imagery intervention with socioemotional learning on the psychological and biophysiological well-being, socioemotional development, cognitive function and academic achievement of elementary school children. PG - 187 LID - 10.1186/s13063-025-08899-3 [doi] LID - 187 AB - BACKGROUND: Mental imagery has long been used in psychological therapies, but only recently did research begin to provide a scientific background for it. Imagery interventions are inexpensive and a substantial body of research supports their effectiveness on anxiety reduction, behavior change, promotion of health outcomes, and adherence to medical interventions, in both adults and children. However, literature on the benefits of relaxation and guided imagery interventions for children in elementary school context is very scarce. This randomized controlled trial (RCT) aims to contribute to that knowledge by implementing and testing the benefits of an intervention program MindRegulation-Socioemotional Learning (MR-SEL) comprising breathing and progressive muscle relaxation, instructions for body posture, and guided imagery with socioemotional learning, conveying adaptive beliefs about oneself, the relationships with others and the environment. METHOD: The MR-SEL intervention will be developed in the classroom for 15 min before learning activities, three times per week, for 5 months, and its effects will be measured on a range of psychosocial and emotional, biophysiological, and cognitive outcomes. Seventeen classes will be randomly assigned to three conditions: (a) relaxation and guided imagery with SEL (MR-SEL); (b) relaxation only; and (c) waitlist control. The RCT includes four data collection times: pretest, intermediate, posttest, and a 6-month follow-up. The sample comprises 259 students, elementary school third and fourth graders, 8-11 years old. The variables measured are well-being, affect, anxiety, emotional regulation, socioemotional competencies, attention and processing speed, and perceived benefits of the intervention. Physiological indicators of emotional arousal, emotional regulation, stress, and well-being are also taken, specifically, heart rate variability, electrodermal activity, actigraphy, and salivary DHEA-S and cortisol. The validity of the measures will be tested for the population and objectives of the study. DISCUSSION: Significant improvements on the children's well-being, socioemotional regulation, cognitive function, physiological activity, and academic performance are expected after 5 months' intervention at posttest and 11 months' follow-up at MR-SEL condition, compared to the relaxation and control conditions. Changes in physiological activity are expected during MR-SEL and relaxation sessions. Emotional regulation, well-being, and anxiety are expected to mediate the effects of the interventions over socioemotional competence, cognitive function, and academic performance. Well-being and anxiety levels at pretest are expected to moderate the interventions' effects. TRIAL REGISTRATION: MINDREGULATION: https://ichgcp.net/clinical-trials-registry/NCT06101225 . Registered 5th October, 2023. CI - (c) 2025. The Author(s). FAU - Galinha, Iolanda Costa AU - Galinha IC AUID- ORCID: 0000-0002-3777-999X AD - Universidade Catolica Portuguesa, Faculdade de Ciencias Humanas, Research Centre for Psychological - Family and Social Wellbeing (CRC-W), Palma de Cima, Lisbon, 1643-026, Portugal. iolanda.galinha@gmail.com. FAU - de Carvalho, Joana Leite da Cunha Sampaio AU - de Carvalho JLDCS AD - Faculdade de Psicologia e de Ciencias da Educacao, Universidade de Lisboa, Portugal - Cidade Universitaria, Alameda da Universidade, Lisbon, Lisbon, 1649-004, Portugal. FAU - de Oliveira, Ana Cristina Pires AU - de Oliveira ACP AD - Independet Researcher, Lisbon, Portugal. FAU - Arriaga, Patricia AU - Arriaga P AUID- ORCID: 0000-0001-5766-0489 AD - CIS-ISCTE, Instituto Universitario de Lisboa, Portugal - Av. das Forcas Armadas, Lisbon, 1649-026, Portugal. FAU - Gaspar, Augusta D AU - Gaspar AD AUID- ORCID: 0000-0001-9758-5727 AD - Universidade Catolica Portuguesa, Faculdade de Ciencias Humanas, Research Centre for Psychological - Family and Social Wellbeing (CRC-W), Palma de Cima, Lisbon, 1643-026, Portugal. FAU - Silva, Hugo P AU - Silva HP AUID- ORCID: 0000-0001-6764-8432 AD - Instituto de Telecomunicacoes, Instituto Superior Tecnico, Av. Rovisco Pais, Lisbon, 1049-001 Lisboa, Portugal. FAU - Ortega, Vitoria AU - Ortega V AD - Independet Researcher, Lisbon, Portugal. LA - eng SI - ClinicalTrials.gov/NCT06101225 GR - Project Nr. 213/2022/Fundacao Bial/ PT - Clinical Trial Protocol PT - Journal Article DEP - 20250603 PL - England TA - Trials JT - Trials JID - 101263253 SB - IM MH - Child MH - Female MH - Humans MH - Male MH - *Academic Success MH - Age Factors MH - *Child Behavior MH - Child Development MH - *Cognition MH - *Emotions MH - *Imagery, Psychotherapy/methods MH - *Learning MH - Mental Health MH - *Relaxation Therapy/methods MH - Time Factors MH - Treatment Outcome MH - Randomized Controlled Trials as Topic PMC - PMC12131549 OTO - NOTNLM OT - Guided imagery OT - Randomized controlled trial OT - Relaxation OT - Self-regulation OT - Socioemotional development COIS- Declarations. Ethics approval and consent to participate: The Study Protocol and the informed consent for participants were approved by the Ethics Committee of the Centro de Investigacao em Psicologia, from the Universidade Autonoma de Lisboa, CIP UAL, Approval Nr. 3/2023, 12-02-2023, and are available at https://osf.io/8pr7c/?view_only=b74eb2f1a489458ea5c816a676181b33 . Consent for publication: Not applicable, no individual person's data in any form is visible in the paper. Competing interests: The authors declare that they have no competing interests. EDAT- 2025/06/04 00:29 MHDA- 2025/06/04 06:27 PMCR- 2025/06/03 CRDT- 2025/06/03 23:47 PHST- 2024/09/06 00:00 [received] PHST- 2025/05/24 00:00 [accepted] PHST- 2025/06/04 06:27 [medline] PHST- 2025/06/04 00:29 [pubmed] PHST- 2025/06/03 23:47 [entrez] PHST- 2025/06/03 00:00 [pmc-release] AID - 10.1186/s13063-025-08899-3 [pii] AID - 8899 [pii] AID - 10.1186/s13063-025-08899-3 [doi] PST - epublish SO - Trials. 2025 Jun 3;26(1):187. doi: 10.1186/s13063-025-08899-3. PMID- 40462129 OWN - NLM STAT- MEDLINE DCOM- 20250604 LR - 20250626 IS - 1745-6215 (Electronic) IS - 1745-6215 (Linking) VI - 26 IP - 1 DP - 2025 Jun 3 TI - Cluster-randomized trial of the implementation of the Responses to Illness Severity Quantification (RISQ) system in children with acute malnutrition 6 to 59 months of age in Ngouri, Chad: the CRIMSON trial protocol. PG - 188 LID - 10.1186/s13063-025-08871-1 [doi] LID - 188 AB - BACKGROUND: The Responses to Illness Severity Quantification (RISQ) System is a scientifically developed clinical decision support tool comprised of four parts: (1) a validated 7-item severity of illness score, (2) age-specific documentation forms, (3) context-relevant score-matched recommendations, and (4) implementation programming. Care recommendations, expertly derived from a panel of clinicians extensively experienced in humanitarian contexts, include frequency of observation, consideration of secondary review, inpatient admission, and transfer into/out of advanced inpatient care areas. The RISQ System is to be used as an adjunct to current care practice to aid clinicians in clinical decision-making. The objective of the CRIMSON study is to estimate the effect of implementation of the RISQ System on mortality and processes of care in a nutritional program. METHODS: A cluster randomized trial will compare the RISQ System to usual care. Eligible clusters are community health centers that enroll patients into the Ministry of Health/ALIMA OptiMA acute malnutrition program in the Ngouri district of Chad. Eligible patients are aged 6-59 months with mid-upper arm circumference (MUAC) < 125 mm and/or edema. Participating centers will be allocated in a 1:1 ratio to usual care or the RISQ System. The primary outcome is mortality to the earlier of 60 days after program entry or program discharge. A 14-month baseline period will precede a 14-month intervention period. With a sample of 20,000 patients in 34 centers (assuming an intraclass correlation coefficient of 0.0005, equal-sized clusters, and 1.5% baseline mortality) provides 80% power to detect a 0.5% absolute decrease in mortality using a one-sided alpha of 0.05. Bayesian logistic regression will be used in analyses of the primary outcome. DISCUSSION: This cluster randomized evaluation of the RISQ System will estimate effect on program mortality as well as provide detailed information on the implementation of a clinical decision support tool in a low-resource humanitarian setting. Improving the precision of clinical determinations about hospitalization could potentially reduce mortality by 30% within nutrition treatment programs. TRIAL REGISTRATION: ClinicalTrials.gov NCT06123390 . First posted date: 2023-11-08. CI - (c) 2025. The Author(s). FAU - Dale, Nancy M AU - Dale NM AD - The Hospital for Sick Children, Toronto, Canada. nancy-m.dale@sickkids.ca. AD - University of Tampere, Tampere, Finland. nancy-m.dale@sickkids.ca. FAU - Hagre, Youssouf Djidita AU - Hagre YD AD - Mother-Child Teaching Hospital (MCTH)/Faculty of Sciences and Human Health at the University of Ndjamena, N'Djamena, Chad. FAU - Shepherd, Susan AU - Shepherd S AD - The Alliance for International Medical Action (ALIMA), Paris, France. FAU - Tomlinson, George AU - Tomlinson G AD - University of Toronto, Toronto, Canada. AD - University Health Network, Toronto, Canada. FAU - Zlotkin, Stanley AU - Zlotkin S AD - The Hospital for Sick Children, Toronto, Canada. AD - University of Toronto, Toronto, Canada. FAU - Ngaradoum, Masra AU - Ngaradoum M AD - The Alliance for International Medical Action (ALIMA), Paris, France. FAU - Bechir, Mahmat AU - Bechir M AD - Department of Food and Applied Nutrition, Ministry of Heath Chad, Faculty of Sciences and Human Health at the University of Ndjamena, N'Djamena, Chad. FAU - Madjissem, Marius AU - Madjissem M AD - Ministry of Health Chad, Lake District, Chad. FAU - Tehoua, Charles AU - Tehoua C AD - The Alliance for International Medical Action (ALIMA), Paris, France. FAU - Parshuram, Christopher AU - Parshuram C AD - The Hospital for Sick Children, Toronto, Canada. AD - University of Toronto, Toronto, Canada. LA - eng SI - ClinicalTrials.gov/NCT06123390 GR - 78730/R2HC-ELRHA/ PT - Clinical Trial Protocol PT - Journal Article DEP - 20250603 PL - England TA - Trials JT - Trials JID - 101263253 SB - IM MH - Humans MH - Infant MH - Child, Preschool MH - Severity of Illness Index MH - Chad/epidemiology MH - Randomized Controlled Trials as Topic MH - *Child Nutrition Disorders/diagnosis/therapy/mortality/physiopathology MH - Nutritional Status MH - *Decision Support Systems, Clinical MH - *Decision Support Techniques MH - Clinical Decision-Making MH - Female MH - *Severe Acute Malnutrition/diagnosis/mortality/therapy PMC - PMC12135466 OTO - NOTNLM OT - Malnutrition OT - Mortality OT - Score OT - Severity of illness COIS- Declarations. Ethics approval and consent to participate 24: Approval granted by the SickKids Research Ethics Board (1000080735) and the Comite National de Bioethique du Tchad. Consent for publication 32: The consent form for patient participation in the study is available on request. Competing interests 28: There is no conflict of interest to report. EDAT- 2025/06/04 00:29 MHDA- 2025/06/04 06:27 PMCR- 2025/06/03 CRDT- 2025/06/03 23:45 PHST- 2024/07/31 00:00 [received] PHST- 2025/05/10 00:00 [accepted] PHST- 2025/06/04 06:27 [medline] PHST- 2025/06/04 00:29 [pubmed] PHST- 2025/06/03 23:45 [entrez] PHST- 2025/06/03 00:00 [pmc-release] AID - 10.1186/s13063-025-08871-1 [pii] AID - 8871 [pii] AID - 10.1186/s13063-025-08871-1 [doi] PST - epublish SO - Trials. 2025 Jun 3;26(1):188. doi: 10.1186/s13063-025-08871-1. PMID- 40461398 OWN - NLM STAT- MEDLINE DCOM- 20250919 LR - 20250919 IS - 2352-7226 (Electronic) IS - 2352-7218 (Linking) VI - 11 IP - 5 DP - 2025 Oct TI - Measurement properties of the SUNRISE Study Parent Questionnaire for assessing sleep and sleep-related family practices. PG - 613-623 LID - S2352-7218(25)00082-8 [pii] LID - 10.1016/j.sleh.2025.04.006 [doi] AB - BACKGROUND: Few questionnaires with established measurement properties can globally measure sleep in preschoolers and sleep-related family practices. OBJECTIVE: To examine (1) concurrent validity of the SUNRISE parent questionnaire against an accelerometer for measuring sleep in preschoolers and (2) test-retest reliability of the questionnaire for sleep and related family practices. METHODS: Sleep was measured using the questionnaire and Actigraph GTX3+ accelerometer using a decision-tree algorithm and the Sadeh algorithm in 1737 preschoolers (4.4+/-0.6years) from 30 countries. Concurrent validity was examined using correlation analysis (duration, timing, and quality), paired t test or the Wilcoxon signed-rank test, Bland-Altman plot (duration, timing), and analysis of sensitivity, specificity, and accuracy (variability). Test-retest variability was examined for sleep and family practice variables in a subsample of 163 participants (4.3+/-0.6years) from eight countries. RESULTS: Questionnaire measures of sleep timing and duration were correlated with the accelerometer measures (r=0.43-0.75; p<.001). Although statistically significant mean differences were observed between questionnaire and accelerometer measures of sleep timing and duration variables, the difference in nighttime sleep duration had a small effect size (-14 min/d; Cohen's d=-0.2). The questionnaire was less able to provide adequate measurement for sleep quality and variability. High levels of reliability were observed for sleep (ICC=0.63-0.83; Kappa=0.53-0.62) and family practice (ICC=0.81-0.94; Kappa=0.73-0.86) variables. CONCLUSION: The SUNRISE questionnaire appears reliable in assessing preschooler sleep characteristics and related family practices, particularly in disadvantaged settings. It could be used in global surveillance of nighttime sleep duration and in studies examining associations of sleep timing and duration with health indicators in preschoolers. CI - Copyright (c) 2025 National Sleep Foundation. Published by Elsevier Inc. All rights reserved. FAU - Zhang, Zhiguang AU - Zhang Z AD - Early Start, School of Education, University of Wollongong, Wollongong, NSW, Australia. Electronic address: zhiguang@uow.edu.au. FAU - Abdeta, Chalchisa AU - Abdeta C AD - Early Start, School of Education, University of Wollongong, Wollongong, NSW, Australia. FAU - Chelly, Mohamed Souhaiel AU - Chelly MS AD - Research Laboratory (LR23JS01), Higher Institute of Sport and Physical Education of Ksar Said, University of Manouba, Tunis, Tunisia. FAU - Cruz, Jesus Del Pozo AU - Cruz JDP AD - Department of Physical Education and Sport, University of Seville, Seville, Spain; Epidemiology of Physical Activity and Fitness Across Lifespan Research Group (EPAfit), Seville, University of Seville, Seville, Spain. FAU - Germana, Leyna AU - Germana L AD - Department of Epidemiology and Biostatistics, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Ghofranipour, Fazlollah AU - Ghofranipour F AD - Department of Health Education and Health Promotion, Tarbiat Modares University, Tehran, Iran. FAU - Ha, Amy Sau-Ching AU - Ha AS AD - Department of Sports Science and Physical Education, Faculty of Education, The Chinese University of Hong Kong, Hong Kong SAR, China. FAU - El Hamdouchi, Asmaa AU - El Hamdouchi A AD - Unite de Recherche en Nutrition et Alimentation, Centre National de l'Energie des Sciences et des Techniques Nucleaires, National Center for Energy Sciences and Nuclear Techniques, Rabat, Morocco. FAU - Tang, Hong Kim AU - Tang HK AD - Department of Epidemiology, Faculty of Public Health, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam. FAU - Hossain, Mohammed Sorowar AU - Hossain MS AD - Department of Emerging and Neglected Diseases, Biomedical Research Foundation, Dhaka, Bangladesh. FAU - Jambaldorj, Bayasgalan AU - Jambaldorj B AD - National Centre for Public Health, Mongolia Ministry of Health, Ulaanbaatar, Mongolia. FAU - Koh, Denise C L AU - Koh DCL AD - Centre of Community Education and Well-being, Faculty of Education, Universiti Kebangsaan Malaysia, Bangi, Malaysia. FAU - Kontsevaya, Anna AU - Kontsevaya A AD - National Medical Research Centre for Therapy and Preventive Medicine, Moscow, Russia. FAU - Lof, Marie AU - Lof M AD - Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. FAU - Lubree, Himangi AU - Lubree H AD - Vadu Rural Health Program KEM Hospital Research Centre, Pune, India. FAU - Jauregui, Alejandra AU - Jauregui A AD - Department of Physical Activity and Healthy Lifestyles, The National Institute of Public Health of Mexico, Cuernavaca, Mexico. FAU - Mwase-Vuma, Tawonga AU - Mwase-Vuma T AD - Centre for Social Research, University of Malawi, Zomba, Malawi. FAU - Oluchiri, Amonje Moses AU - Oluchiri AM AD - Wellness for Greatness Kenya, Nairobi, Kenya. FAU - Oluwayomi, Aoko AU - Oluwayomi A AD - Department of Human Kinetics and Health Education, University of Lagos, Lagos, Nigeria. FAU - Reilly, John J AU - Reilly JJ AD - Physical Activity and Health Group, Department of Psychological Sciences and Health, University of Strathclyde, Glasgow, Scotland. FAU - Roos, Eva AU - Roos E AD - Folkhalsen Research Center, Helsinki, Finland. FAU - Staiano, Amanda E AU - Staiano AE AD - Division of Population and Public Health Science, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA. FAU - Suherman, Adang AU - Suherman A AD - Faculty of Sport and Health Education, Universitas Pendidikan Indonesia, Bandung, Indonesia. FAU - Tanaka, Chiaki AU - Tanaka C AD - Department of Human Nutrition, Tokyo Kasei Gakuin University, Tokyo, Japan. FAU - Teo, Wei-Peng AU - Teo WP AD - Physical Education and Sports Science Department, National Institute of Education, Nanyang Technological University, Singapore, Singapore. FAU - Turab, Ali AU - Turab A AD - Precision Health Consultants (PHC Global), Karachi, Pakistan. FAU - Uzicanin, Edin AU - Uzicanin E AD - Faculty of Physical Education and Sport, University of Tuzla, Tuzla, Bosnia and Herzegovina. FAU - Veldman, Sanne L C AU - Veldman SLC AD - Mulier Institute, Utrecht, the Netherlands. FAU - Webster, E Kipling AU - Webster EK AD - Department of Kinesiology, Recreation, and Sport Studies, University of Tennessee, Knoxville, Tennessee, USA. FAU - Wickramasinghe, Pujitha AU - Wickramasinghe P AD - Department of Paediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. FAU - Aunampai, Aubdul AU - Aunampai A AD - Thailand Physical Activity Knowledge Development Centre, Institute for Population and Social Research, Mahidol University, Bangkok, Thailand. FAU - Okely, Anthony AU - Okely A AD - School of Health and Society, University of Wollongong, Wollongong, NSW, Australia. LA - eng PT - Journal Article DEP - 20250602 PL - United States TA - Sleep Health JT - Sleep health JID - 101656808 SB - IM MH - Humans MH - Surveys and Questionnaires/standards MH - *Sleep MH - Child, Preschool MH - Male MH - Female MH - Reproducibility of Results MH - *Parents/psychology MH - Actigraphy MH - Accelerometry OTO - NOTNLM OT - Early childhood OT - Measurement OT - Public health OT - Sleep health COIS- Declaration of conflicts of interest None. EDAT- 2025/06/04 00:29 MHDA- 2025/09/20 00:31 CRDT- 2025/06/03 22:11 PHST- 2024/11/28 00:00 [received] PHST- 2025/04/17 00:00 [revised] PHST- 2025/04/22 00:00 [accepted] PHST- 2025/09/20 00:31 [medline] PHST- 2025/06/04 00:29 [pubmed] PHST- 2025/06/03 22:11 [entrez] AID - S2352-7218(25)00082-8 [pii] AID - 10.1016/j.sleh.2025.04.006 [doi] PST - ppublish SO - Sleep Health. 2025 Oct;11(5):613-623. doi: 10.1016/j.sleh.2025.04.006. Epub 2025 Jun 2. PMID- 40457460 OWN - NLM STAT- MEDLINE DCOM- 20250603 LR - 20261015 IS - 1750-1172 (Electronic) IS - 1750-1172 (Linking) VI - 20 IP - 1 DP - 2025 Jun 2 TI - Lung volumetry of osteogenesis imperfecta type 3 subjects is not correlated with thoracic scoliosis and anthropometric data. PG - 265 LID - 10.1186/s13023-025-03797-y [doi] LID - 265 AB - BACKGROUND: This study aimed to investigate the relationship between lung volumetry, thoracic scoliosis, and anthropometric data (height, weight, BMI) in patients with Osteogenesis Imperfecta (OI) Type 3. Three hypotheses were tested: H1 predicted lower lung volumes in patients with OI Type 3 compared to controls, H2 predicted differences between right and left lung volumes in patients with OI Type 3 due to chest deformities, and H3 predicted a correlation between lung volumes in patients with OI Type 3 and their thoracic scoliosis and anthropometric data. METHODS: Age, biological sex, weight, height, body mass index (BMI), Cobb angle of thoracic scoliosis, left and right lung volumes, and total lung volume were recorded. CT scans were performed on all participants, and lung volumetry was analysed using specialised software. The intraclass correlation coefficient was used to assess measurement reliability, and statistical analysis was conducted to examine correlations between variables. RESULTS: Patients with OI had significantly lower total lung volumes than controls (p < 0.001). However, no significant correlation was found between lung volumetry and scoliosis (r =- 0.406; p = 0.244), age (r = 0.201; p = 0.578), height (r = 0.479; p = 0.162), weight (r = 0.358; p = 0.310), or BMI (r = - 0.042; p = 0.907) in OI patients. In the control group, significant correlations were observed between lung volume and height (r = 0.756; p = 0.011) and weight (r = 0.638; p = 0.047). CONCLUSION: OI type 3 patients have lower lung volumes than healthy subjects, but have no left and right lung volume differences. In addition, they did not present any correlation between lung volumes and scoliosis, height, weight, and body mass index. CI - (c) 2025. The Author(s). FAU - Lopez-Beneyto, Jorge AU - Lopez-Beneyto J AD - Facultat de Medicina i Odontologia, Universitat de Valencia, Valencia, Spain. FAU - Ponte, Elisabetta AU - Ponte E AD - Complejo Hospitalario de Toledo, Toledo, Spain. FAU - Martinez-Sanjuan, Vicente AU - Martinez-Sanjuan V AD - ASCIRES Biomedical Group, Valencia, Spain. FAU - Fernandez-Velilla, Maria AU - Fernandez-Velilla M AD - La Paz University Hospital Biomedical Research Foundation, Madrid, Spain. FAU - Mata-Escolano, Federico AU - Mata-Escolano F AD - ASCIRES Biomedical Group, Valencia, Spain. FAU - Torres-Sanchez, Maribel AU - Torres-Sanchez M AD - La Paz University Hospital Biomedical Research Foundation, Madrid, Spain. FAU - Garcia-Rio, Francisco AU - Garcia-Rio F AD - La Paz University Hospital Biomedical Research Foundation, Madrid, Spain. FAU - Nalla, Shahed AU - Nalla S AD - Facultat de Medicina i Odontologia, Universitat de Valencia, Valencia, Spain. AD - Faculty of Health Sciences, University of Johannesburg, Johannesburg, South Africa. FAU - Ercan, Ilker AU - Ercan I AD - Bursa Uludag Universitesi, Bursa, Turkiye. FAU - Sanchis-Gimeno, Juan A AU - Sanchis-Gimeno JA AUID- ORCID: 0000-0002-2599-8474 AD - Facultat de Medicina i Odontologia, Universitat de Valencia, Valencia, Spain. juan.sanchis@uv.es. LA - eng GR - BF14_005/Fundacion Eresa/ GR - OTR2016-15543INVES/Care4Brittlebones Foundation/ GR - UV-INV_AE18-773873/Universitat de Valencia/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250602 PL - England TA - Orphanet J Rare Dis JT - Orphanet journal of rare diseases JID - 101266602 RN - Osteogenesis imperfecta, type 3 SB - IM MH - Humans MH - *Scoliosis/pathology/physiopathology/diagnostic imaging MH - *Osteogenesis Imperfecta/pathology/physiopathology/diagnostic imaging MH - Female MH - Male MH - *Lung/pathology MH - Adolescent MH - Child MH - Adult MH - Anthropometry MH - Body Mass Index MH - Young Adult MH - Tomography, X-Ray Computed MH - Lung Volume Measurements PMC - PMC12131355 OTO - NOTNLM OT - Anthropometric data OT - Computed tomography OT - Lung volumetry OT - Osteogenesis imperfecta OT - Scoliosis COIS- Declarations. Ethics approval and consent to participate: The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Institutional Review Board (or Ethics Committee) of the University of Valencia (protocol code H1417174744011). Consent for publication: Written informed consent was obtained from all subjects involved in the study. Written informed consent was obtained from the patients to publish this paper. Competing interests: The authors declare no conflict of interest. The funders had no role in the study's design, in the collection, analyses, or interpretation of data, in the writing of the manuscript, or in the decision to publish the results. EDAT- 2025/06/03 00:29 MHDA- 2025/06/03 06:26 PMCR- 2025/06/02 CRDT- 2025/06/02 23:45 PHST- 2024/07/06 00:00 [received] PHST- 2025/05/14 00:00 [accepted] PHST- 2025/06/03 06:26 [medline] PHST- 2025/06/03 00:29 [pubmed] PHST- 2025/06/02 23:45 [entrez] PHST- 2025/06/02 00:00 [pmc-release] AID - 10.1186/s13023-025-03797-y [pii] AID - 3797 [pii] AID - 10.1186/s13023-025-03797-y [doi] PST - epublish SO - Orphanet J Rare Dis. 2025 Jun 2;20(1):265. doi: 10.1186/s13023-025-03797-y. PMID- 40457287 OWN - NLM STAT- MEDLINE DCOM- 20250603 LR - 20250605 IS - 1471-2474 (Electronic) IS - 1471-2474 (Linking) VI - 26 IP - 1 DP - 2025 Jun 2 TI - Tracing neurodevelopment and growth pattern in six-year-old children with idiopathic clubfoot: a national cohort study. PG - 542 LID - 10.1186/s12891-025-08810-w [doi] LID - 542 AB - STUDY DESIGN: Population-based retrospective cohort study. OBJECTIVES: The developmental impact of idiopathic clubfoot on children remains underexplored. This study investigates neurodevelopment and physical growth in children with idiopathic clubfoot up to age six. METHODS: This population-based retrospective cohort study was conducted in South Korea (2009-2019) using linked data from National Health Insurance Service. The cohort included children diagnosed with idiopathic clubfoot and 1:10 exact match of healthy control children. Neurodevelopmental assessments were conducted using the validated Korean Developmental Screening Test, which covers six domains: gross motor skills, fine motor skills, cognition, language, social skills, and self-regulation, for children aged 42-71 months. Secondary outcomes measured were height and body mass index (BMI) Z-score during the same period. RESULTS: The cohort comprised 484 children with idiopathic clubfoot and 4,840 matched healthy control children. Children with clubfoot had a higher rate of premature birth (7.44% vs. 3.66%, p < 0.0001) and lower birth weight (3.08 +/- 0.59 kg vs. 3.20 +/- 0.46 kg, p < 0.0001) compared to the healthy control children. In-depth evaluation of all six neurodevelopmental domains showed significant differences in children with clubfoot (overall aOR, 3.671; 95% CI, 2.463-5.471). Children with clubfoot showed a significant height delay (Z score, -1.63 below), but no BMI difference was noted. CONCLUSIONS: Children with idiopathic clubfoot demonstrated increased risk of neurodevelopmental delays and reduced height compared to their peers. These findings underscore the importance of early recognition and ongoing monitoring by parents and pediatricians. CI - (c) 2025. The Author(s). FAU - Cho, Sung Tan AU - Cho ST AD - Department of Orthopaedic Surgery, Seoul Seonam Hospital, Seoul, Republic of Korea. FAU - Yoo, Ha-Na AU - Yoo HN AD - Department of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University School of Medicine, 335 Pangyo-Ro, Bundang-GuGyeonggi-Do, Seongnam-Si, 13488, Republic of Korea. FAU - Jeong, Simho AU - Jeong S AD - Department of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University School of Medicine, 335 Pangyo-Ro, Bundang-GuGyeonggi-Do, Seongnam-Si, 13488, Republic of Korea. FAU - Kim, Ju Hee AU - Kim JH AD - Department of Pediatrics, Kyung Hee University Medical Center, Seoul, Republic of Korea. FAU - Ha, Eun Kyo AU - Ha EK AD - Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea. FAU - Han, Bo Eun AU - Han BE AD - Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea. AD - Multi-Omics Research Center, CHA Future Medicine Research Institute CHA University School of Medicine, Seongnam, Republic of Korea. FAU - Liawrungrueang, Wongthawat AU - Liawrungrueang W AD - Department of Orthopaedic Surgery, School of Medicine, University of Phayao, Phayao, 56000, Thailand. FAU - Han, Man Yong AU - Han MY AD - Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea. drmesh@gmail.com. FAU - Lee, Soonchul AU - Lee S AD - Department of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University School of Medicine, 335 Pangyo-Ro, Bundang-GuGyeonggi-Do, Seongnam-Si, 13488, Republic of Korea. Lsceline78@gmail.com. LA - eng GR - HR22C1605-C/Korea Health Industry Development Institute/Republic of Korea GR - 2022R1A2C2005916/National Research Foundation of Korea/ PT - Journal Article DEP - 20250602 PL - England TA - BMC Musculoskelet Disord JT - BMC musculoskeletal disorders JID - 100968565 SB - IM MH - Humans MH - *Clubfoot/epidemiology/physiopathology/diagnosis/complications MH - Male MH - Female MH - Retrospective Studies MH - Republic of Korea/epidemiology MH - Child MH - Child, Preschool MH - *Child Development/physiology MH - Motor Skills MH - Cohort Studies MH - Body Height MH - Body Mass Index PMC - PMC12131360 OTO - NOTNLM OT - Cohort study OT - Developmental delay OT - Idiopathic clubfoot OT - Neurodevelopment OT - Physical growth COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Institutional Review Board (IRB) of CHA Bundang Medical Center (IRB number: 2023-10-204). Approval date: 2023-10-23. This study was performed in line with the principles of the Declaration of Helsinki. Due to the study's retrospective design and the use of anonymized clinical data for analysis, the requirement for informed consent was exempted. Additionally, the Institutional Review Board (IRB) of CHA Bundang Medical Center granted approval for this exemption (IRB number: 2023-10-204). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/06/03 00:29 MHDA- 2025/06/03 06:27 PMCR- 2025/06/02 CRDT- 2025/06/02 23:38 PHST- 2024/07/11 00:00 [received] PHST- 2025/05/27 00:00 [accepted] PHST- 2025/06/03 06:27 [medline] PHST- 2025/06/03 00:29 [pubmed] PHST- 2025/06/02 23:38 [entrez] PHST- 2025/06/02 00:00 [pmc-release] AID - 10.1186/s12891-025-08810-w [pii] AID - 8810 [pii] AID - 10.1186/s12891-025-08810-w [doi] PST - epublish SO - BMC Musculoskelet Disord. 2025 Jun 2;26(1):542. doi: 10.1186/s12891-025-08810-w. PMID- 40456684 OWN - NLM STAT- MEDLINE DCOM- 20250916 LR - 20250917 IS - 1365-2982 (Electronic) IS - 1350-1925 (Print) IS - 1350-1925 (Linking) VI - 37 IP - 10 DP - 2025 Oct TI - Neuropathic Gastroduodenal Disorders Can Be Diagnosed by Non-Invasive Body Surface Gastric Mapping: A Comparison With Antroduodenal Manometry. PG - e70087 LID - 10.1111/nmo.70087 [doi] LID - e70087 AB - BACKGROUND: Antroduodenal manometry (ADM) is the gold standard for diagnosing myopathy and neuropathy in patients with upper gastrointestinal (GI) disorders. However, ADM is invasive and costly. Body surface gastric mapping (BSGM) has emerged as a non-invasive test to assess gastric function. This study evaluates the correlation between BSGM and ADM in children. METHODS: Clinically indicated ADM was performed using high-resolution water-perfused motility catheters, with simultaneous BSGM. Real-time symptoms were tracked using a validated symptom logging app at 15-min intervals, and Nausea Severity Scale (NSS) scores were recorded. Protocols involved a 2 h fast, provocative testing, a meal, and over 1 h of post-prandial recordings. ADM tracings were categorized into neuropathy, myopathy, post-prandial hypomotility, or normal. BSGM metrics included principal gastric frequency, BMI-adjusted amplitude, and Rhythm Index. Gastric emptying data were also evaluated. RESULTS: Fifteen subjects were recruited (13 female; ages 10-19 years, BMI 20.6 +/- 3.5 kg/m(2)). ADM results showed neuropathy (n = 4), myopathic CIPO (myopathy) (n = 1), post-prandial hypomotility (n = 4), and normal motility (n = 6). Patients with neuropathy had lower rhythm stability (0.16 +/- 0.03 vs. 0.38 +/- 0.17; p = 0.001), accompanied by higher nausea scores (8.2 +/- 1.2 vs. 3.15 +/- 2.9; p < 0.001) and bloating (7.3 +/- 0.9 vs. 2.1 +/- 2.0; p < 0.001). ADM neuropathy correlated completely with dysrhythmia on BSGM. Normal ADM were consistent with normal BSGM in 83.3% of cases. Delayed gastric emptying did not correlate with a neuropathic diagnosis. CONCLUSION: Dysrhythmic BSGM phenotype reliably identified gastrointestinal neuropathy with identical results to ADM, with significant correlations to nausea and bloating severity. This study supports considering BSGM as an actionable biomarker when performing ADM is not feasible. CI - (c) 2025 The Author(s). Neurogastroenterology & Motility published by John Wiley & Sons Ltd. FAU - Sadaka, Christian AU - Sadaka C AUID- ORCID: 0009-0003-5665-5743 AD - Gastroenterology, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Pennsylvania, USA. FAU - Xu, Binghong AU - Xu B AD - Gastroenterology, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Pennsylvania, USA. FAU - Benitez, Alain J AU - Benitez AJ AD - Gastroenterology, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Pennsylvania, USA. AD - Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. FAU - Orians, Carolyn M AU - Orians CM AD - Gastroenterology, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Pennsylvania, USA. FAU - Bowerman, Corey AU - Bowerman C AD - Gastroenterology, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Pennsylvania, USA. FAU - Dourlain, Jordan AU - Dourlain J AD - Gastroenterology, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Pennsylvania, USA. FAU - Skaggs, Beth AU - Skaggs B AD - Gastroenterology, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Pennsylvania, USA. FAU - Konka, Kimberly G AU - Konka KG AD - Gastroenterology, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Pennsylvania, USA. FAU - Roshkovan, Lexi AU - Roshkovan L AD - Gastroenterology, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Pennsylvania, USA. FAU - Humphrey, Gayl AU - Humphrey G AUID- ORCID: 0000-0002-2837-5707 AD - Department of Surgery, The University of Auckland, Auckland, New Zealand. FAU - Calder, Stefan AU - Calder S AD - Department of Surgery, The University of Auckland, Auckland, New Zealand. AD - Alimetry Ltd., Auckland, New Zealand. FAU - Schamberg, Gabriel AU - Schamberg G AUID- ORCID: 0000-0002-4188-9614 AD - Department of Surgery, The University of Auckland, Auckland, New Zealand. AD - Alimetry Ltd., Auckland, New Zealand. FAU - O'Grady, Greg AU - O'Grady G AUID- ORCID: 0000-0002-5998-1080 AD - Department of Surgery, The University of Auckland, Auckland, New Zealand. AD - Alimetry Ltd., Auckland, New Zealand. FAU - Gharibans, Armen A AU - Gharibans AA AUID- ORCID: 0000-0002-9139-4740 AD - Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. AD - Department of Surgery, The University of Auckland, Auckland, New Zealand. AD - Alimetry Ltd., Auckland, New Zealand. FAU - Mousa, Hayat AU - Mousa H AD - Gastroenterology, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Pennsylvania, USA. AD - Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. LA - eng PT - Comparative Study PT - Journal Article DEP - 20250602 PL - England TA - Neurogastroenterol Motil JT - Neurogastroenterology and motility JID - 9432572 SB - IM MH - Humans MH - Female MH - *Manometry/methods MH - Child MH - Male MH - Adolescent MH - Young Adult MH - Gastric Emptying/physiology MH - *Gastrointestinal Diseases/diagnosis/physiopathology MH - *Duodenal Diseases/diagnosis/physiopathology MH - Gastrointestinal Motility/physiology MH - Stomach/physiopathology PMC - PMC12435801 OTO - NOTNLM OT - antral hypomotility OT - antroduodenal manometry OT - body surface gastric mapping OT - functional dyspepsia OT - gastroparesis OT - neuropathy COIS- G.O. and A.A.G. hold grants and intellectual property in Gastrointestinal Electrophysiology. G.O., A.A.G., S.C., and G.S. are shareholders and/or employees of Alimetry. The remaining authors declare no conflicts of interest. EDAT- 2025/06/03 00:29 MHDA- 2025/09/16 20:02 PMCR- 2025/09/15 CRDT- 2025/06/02 22:22 PHST- 2025/03/26 00:00 [revised] PHST- 2024/11/14 00:00 [received] PHST- 2025/05/09 00:00 [accepted] PHST- 2025/09/16 20:02 [medline] PHST- 2025/06/03 00:29 [pubmed] PHST- 2025/06/02 22:22 [entrez] PHST- 2025/09/15 00:00 [pmc-release] AID - NMO70087 [pii] AID - 10.1111/nmo.70087 [doi] PST - ppublish SO - Neurogastroenterol Motil. 2025 Oct;37(10):e70087. doi: 10.1111/nmo.70087. Epub 2025 Jun 2. PMID- 40455447 OWN - NLM STAT- MEDLINE DCOM- 20250602 LR - 20260518 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 8 IP - 6 DP - 2025 Jun 2 TI - Model for Musculoskeletal Injury Risk Factors Among US Army Basic Combat Trainees. PG - e2513177 LID - 10.1001/jamanetworkopen.2025.13177 [doi] LID - e2513177 AB - IMPORTANCE: Musculoskeletal injuries (MSKIs) are pervasive problems in novice training environments. Evaluation of modifiable and nonmodifiable risk factors of MSKI risk prior to entry into these environments is largely understudied. OBJECTIVE: To provide military leaders, civilian and military clinicians, and physical training instructors with an MSKI risk model for identifying low-, moderate-, and high-risk profiles among individuals starting US Army Basic Combat Training (BCT) or a physical training program. DESIGN, SETTING, AND PARTICIPANTS: In this prospective cohort study, data collection was conducted between August 5, 2017, and April 15, 2023, at 2 US Army BCT sites. The sample consisted of volunteer trainees between the ages of 17 and 41 years. They were followed up from the start of BCT. Data analyses were conducted from April to September 2024. EXPOSURES: Data for the factors potentially associated with MSKI were collected during the first week of BCT and included blood draws, total body dual-energy x-ray absorptiometry, and muscle power test results; surveys of demographics, medical history, physical activity, psychological characteristics, and sleep patterns; and physical fitness results. MAIN OUTCOMES AND MEASURES: MSKIs identified using International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) codes. Logistic regression-based models estimating the risk of MSKI were generated using 5-fold internal cross-validation for the total cohort, males, and females. Traffic light model examples of low (green), moderate (amber), and high (red) MSKI risk tiers were produced. RESULTS: In this cohort study of 2988 Army trainees (median [IQR] age, 19.0 [19.0-22.0] years; 1880 males [62.9%]), 729 females (49.0%) and 758 males (51.0%) had an ICD-10 code-identified MSKI, and 1067 (35.7%) had more than 1 ICD-10 code-identified MSKI. Factors associated with increased MSKI risk in the total cohort and female- and male-specific MSKI risk models (with areas under the receiver operator characteristic curve of 0.701, 0.678, and 0.661, respectively) encompassed 7 variable categories: demographics; anthropometrics and body composition; nutritional status; medical and health history; history of sports and past or current physical activity or fitness; psychological factors (ie, pain, grit, and hardiness); and sleep parameters. CONCLUSIONS AND RELEVANCE: This cohort study presents a tiered approach to identifying persons at increased MSKI risk before the start of a physical training program. Applying a tiered quantification risk metric and incorporating multifactorial interventions from these findings may play a role in reduced MSKI risk. FAU - Foulis, Stephen A AU - Foulis SA AD - Military Performance Division, Army Research Institute of Environmental Medicine, Natick, Massachusetts. FAU - Proctor, Susan P AU - Proctor SP AD - Military Performance Division, Army Research Institute of Environmental Medicine, Natick, Massachusetts. AD - Research Service, Veterans Affairs (VA) Boston Healthcare System, Boston, Massachusetts. FAU - Spiering, Barry A AU - Spiering BA AD - Military Performance Division, Army Research Institute of Environmental Medicine, Natick, Massachusetts. FAU - Walker, Leila A AU - Walker LA AD - Military Performance Division, Army Research Institute of Environmental Medicine, Natick, Massachusetts. FAU - Guerriere Aaron, Katelyn AU - Guerriere Aaron K AD - Military Performance Division, Army Research Institute of Environmental Medicine, Natick, Massachusetts. FAU - Castellani, Colleen M AU - Castellani CM AD - Military Performance Division, Army Research Institute of Environmental Medicine, Natick, Massachusetts. FAU - Hussian, Ian M AU - Hussian IM AD - Military Performance Division, Army Research Institute of Environmental Medicine, Natick, Massachusetts. FAU - Heaton, Kristin J AU - Heaton KJ AD - Military Performance Division, Army Research Institute of Environmental Medicine, Natick, Massachusetts. FAU - Bouxsein, Mary L AU - Bouxsein ML AD - Endocrine Unit, Massachusetts General Hospital, Boston. AD - Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts. AD - Department of Orthopedic Surgery, Harvard Medical School, Boston, Massachusetts. FAU - Gaffney-Stomberg, Erin AU - Gaffney-Stomberg E AD - Combat Feeding Division, Combat Capabilities Development Command-Soldier Center, Natick, Massachusetts. FAU - Fraley, Amy L AU - Fraley AL AD - Department of Exercise Science, University of South Carolina, Columbia. FAU - Popp, Kristin L AU - Popp KL AD - Military Performance Division, Army Research Institute of Environmental Medicine, Natick, Massachusetts. AD - Endocrine Unit, Massachusetts General Hospital, Boston. FAU - Davis, Irene S AU - Davis IS AD - School of Physical Therapy and Rehabilitation Sciences, University of South Florida, Tampa. FAU - Staab, Jeffery S AU - Staab JS AD - Military Performance Division, Army Research Institute of Environmental Medicine, Natick, Massachusetts. FAU - Staab, Janet E AU - Staab JE AD - Military Performance Division, Army Research Institute of Environmental Medicine, Natick, Massachusetts. FAU - Judkins, Jason L AU - Judkins JL AD - Military Performance Division, Army Research Institute of Environmental Medicine, Natick, Massachusetts. FAU - Merkle, Shannon L AU - Merkle SL AD - Military Performance Division, Army Research Institute of Environmental Medicine, Natick, Massachusetts. FAU - Ritland, Bradley M AU - Ritland BM AD - Military Performance Division, Army Research Institute of Environmental Medicine, Natick, Massachusetts. FAU - Matheny, Ronald W Jr AU - Matheny RW Jr AD - Military Performance Division, Army Research Institute of Environmental Medicine, Natick, Massachusetts. AD - Military Operational Medicine Research Program, Fort Detrick, Maryland. FAU - Hauret, Keith G AU - Hauret KG AD - Defense Centers for Public Health-Aberdeen, Aberdeen, Maryland. FAU - Canham-Chervak, Michelle AU - Canham-Chervak M AD - Defense Centers for Public Health-Aberdeen, Aberdeen, Maryland. FAU - McClung, James P AU - McClung JP AD - Military Nutrition Division, Army Research Institute of Environmental Medicine, Natick, Massachusetts. FAU - Jones, Bruce H AU - Jones BH AD - Defense Centers for Public Health-Aberdeen, Aberdeen, Maryland. FAU - Friedl, Karl E AU - Friedl KE AD - Office of the Senior Scientist, Army Research Institute of Environmental Medicine, Natick, Massachusetts. FAU - Hughes, Julie M AU - Hughes JM AD - Military Performance Division, Army Research Institute of Environmental Medicine, Natick, Massachusetts. FAU - Taylor, Kathryn M AU - Taylor KM AD - Military Performance Division, Army Research Institute of Environmental Medicine, Natick, Massachusetts. CN - ARIEM Reduction in Musculoskeletal Injury (ARMI) Study Team LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. DEP - 20250602 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Humans MH - Male MH - *Military Personnel/statistics & numerical data/education MH - Female MH - Risk Factors MH - Adult MH - Prospective Studies MH - United States/epidemiology MH - Young Adult MH - Adolescent MH - *Musculoskeletal System/injuries MH - *Musculoskeletal Diseases/epidemiology PMC - PMC12131099 COIS- Conflict of Interest Disclosures: Dr Popp reported receiving grants from the US Department of Defense during the conduct of the study. Dr Davis reported receiving funding for the Army Landing Impacts and Injury Study from a contract with Mass General Brigham Spaulding Rehabilitation during the conduct of the study. Dr Merkle reported being a service member at a military research laboratory outside the submitted work. Dr Taylor reported receiving personal fees from Eight Sleep outside the submitted work. No other disclosures were reported. FIR - Bartlett, Paul M IR - Bartlett PM FIR - Cohen, Bruce S IR - Cohen BS FIR - Frykman, Peter N IR - Frykman PN FIR - Geddis, Alyssa V IR - Geddis AV FIR - Kusumpa, Soothesuk IR - Kusumpa S FIR - Johnson, Caleb D IR - Johnson CD FIR - Nguyen, Vy T IR - Nguyen VT FIR - Pecorelli, Vincent P IR - Pecorelli VP FIR - Reynoso, Marinaliz IR - Reynoso M FIR - Richardson, Melissa D IR - Richardson MD FIR - Smith, Nathaniel I IR - Smith NI FIR - Zeppetelli, David J IR - Zeppetelli DJ FIR - Nindl, Bradley C IR - Nindl BC FIR - Flanagan, Shawn D IR - Flanagan SD FIR - Sacko, Ryan S IR - Sacko RS EDAT- 2025/06/02 12:31 MHDA- 2025/06/02 12:32 PMCR- 2025/06/02 CRDT- 2025/06/02 11:33 PHST- 2025/06/02 12:32 [medline] PHST- 2025/06/02 12:31 [pubmed] PHST- 2025/06/02 11:33 [entrez] PHST- 2025/06/02 00:00 [pmc-release] AID - 2834755 [pii] AID - zoi250435 [pii] AID - 10.1001/jamanetworkopen.2025.13177 [doi] PST - epublish SO - JAMA Netw Open. 2025 Jun 2;8(6):e2513177. doi: 10.1001/jamanetworkopen.2025.13177. PMID- 40454694 OWN - NLM STAT- MEDLINE DCOM- 20251030 LR - 20260508 IS - 1541-3144 (Electronic) IS - 0194-2638 (Linking) VI - 45 IP - 6 DP - 2025 TI - Physical Literacy Profile Questionnaire (PLP-Quest): Development and Measurement Properties for Children and Youth with Disabilities. PG - 956-974 LID - 10.1080/01942638.2025.2509545 [doi] AB - AIM: To develop the Physical Literacy Profile Questionnaire (PLP-Quest) for children, adolescents, and young adults with disabilities and to assess its measurement properties. METHOD: The PLP-Quest was developed based on the physical literacy framework proposed by the Australian Sports Commission, and following the Consensus-based Standards for the selection of health Measurement Instruments (COSMIN) criteria for instrument development. After development, the following PLP-Quest measurement properties were investigated: content validity, structural validity, internal consistency and test-retest reliability. RESULTS: All PLP-Quest items were considered relevant and comprehensive by 50 caregivers and 50 health professionals. In structural validity analysis, with 109 responses, two items were removed, resulting in a final set of 22 items in PLP-Quests' final version. There was predominance of a single factor in the principal component analysis, confirming unidimensionality. Cronbach's alpha analysis showed that the instrument had good internal consistency (alpha = 0.93). The analysis of the intraclass correlation coefficient (ICC) showed that the instrument had good test-retest reliability (ICC= 0.92, 95% CI: 0.87-0.96). INTERPRETATION: Preliminary assessments of the measurement properties of the PLP-Quest indicate that this instrument has the potential to assess physical literacy in children, adolescents, and young adults with disabilities. FAU - Ferreira, Rafaela G AU - Ferreira RG AD - Graduate Program in Rehabilitation Sciences, School of Physical Education, Physical Therapy and Occupational Therapy, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. FAU - Souza, Mariane G AU - Souza MG AD - Graduate Program in Rehabilitation Sciences, School of Physical Education, Physical Therapy and Occupational Therapy, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. FAU - Oliveira, Joao Victor B AU - Oliveira JVB AD - Undergraduate Program in Physical Therapy, School of Physical Education, Physical Therapy and Occupational Therapy, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. FAU - Chaves, Karen C S AU - Chaves KCS AD - Graduate Program in Rehabilitation Sciences, School of Physical Education, Physical Therapy and Occupational Therapy, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. FAU - Silva, Luana C AU - Silva LC AD - Graduate Program in Rehabilitation Sciences, School of Physical Education, Physical Therapy and Occupational Therapy, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. FAU - Montenegro, Lourdes C C AU - Montenegro LCC AD - Statistical Department, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. FAU - Santos, Marcos Antonio C AU - Santos MAC AD - Statistical Department, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. FAU - Clutterbuck, Georgina L AU - Clutterbuck GL AD - School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia. FAU - Junior, Ricardo R S AU - Junior RRS AD - Graduate Program in Rehabilitation Sciences, School of Physical Education, Physical Therapy and Occupational Therapy, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. FAU - Leite, Hercules R AU - Leite HR AD - Graduate Program in Rehabilitation Sciences, School of Physical Education, Physical Therapy and Occupational Therapy, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. LA - eng PT - Journal Article DEP - 20250602 PL - England TA - Phys Occup Ther Pediatr JT - Physical & occupational therapy in pediatrics JID - 8109120 SB - IM MH - Humans MH - Adolescent MH - Child MH - Male MH - Surveys and Questionnaires MH - Reproducibility of Results MH - Female MH - Young Adult MH - Psychometrics MH - *Health Literacy MH - *Children with Disabilities MH - Australia MH - *Persons with Disabilities OTO - NOTNLM OT - Adolescents OT - children OT - disabilities OT - participation OT - physical activity OT - physical literacy EDAT- 2025/06/02 12:32 MHDA- 2025/10/30 12:29 CRDT- 2025/06/02 08:03 PHST- 2025/10/30 12:29 [medline] PHST- 2025/06/02 12:32 [pubmed] PHST- 2025/06/02 08:03 [entrez] AID - 10.1080/01942638.2025.2509545 [doi] PST - ppublish SO - Phys Occup Ther Pediatr. 2025;45(6):956-974. doi: 10.1080/01942638.2025.2509545. Epub 2025 Jun 2. PMID- 40454160 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260924 IS - 2475-2991 (Electronic) IS - 2475-2991 (Linking) VI - 9 IP - Suppl 1 DP - 2025 Feb TI - Cognitive Interviewing to Improve Infant and Young Child Dietary Assessments in the Nepal Demographic and Health Survey. PG - 104453 LID - 10.1016/j.cdnut.2024.104453 [doi] LID - 104453 AB - BACKGROUND: The Demographic and Health Survey (DHS) is the primary source of nationally representative nutrition data for many countries and is important in shaping national nutrition policy, advocacy, and research. Without careful testing and adaptation to local contexts, findings are at risk of inaccurately representing respondents' behaviors and key nutritional indicators. OBJECTIVES: This study used a cognitive interviewing approach to assess mothers' comprehension, retrieval, judgment, and response to the infant and young child feeding (IYCF) dietary assessment module questions in the Nepal DHS-8 Woman's Questionnaire. METHODS: A cross-sectional qualitative study was conducted in December 2021, using semistructured cognitive interviews, among 54 mothers of children 6-23 mo of age across 3 regions of Nepal. Interviews were analyzed to identify issues in participant understanding of questions, as well as cognitive challenges or benefits of a longer introduction to the IYCF dietary assessment module, as compared with the original shorter introduction and challenges or benefits to using closed-ended compared with open-ended questions. RESULTS: Cognitive challenges were identified, including issues with judgment of certain food categories resulting in misclassification, comprehension of certain concepts, and comprehension of certain instructions for the dietary assessment that resulted in the variability of food and liquids recalled by mothers. CONCLUSIONS: These findings carry substantial implications for the measurement of the diet quality of infants and young children (IYC) in Nepal, and similar cognitive challenges may exist in other contexts. Although this current study is not able to answer the exact extent to which the accuracy and precision of IYCF indicators are affected by these cognitive challenges, these findings indicate that current measurements may be subject to over or underestimation and there is a need for further research in this area to understand the degree of measurement error related to these challenges. CI - (c) 2024 The Authors. FAU - Khadka, Seema AU - Khadka S AD - Helen Keller International Nepal, Lalitpur, Nepal. FAU - Sharma, Nisha AU - Sharma N AD - Helen Keller International Nepal, Lalitpur, Nepal. FAU - Yuen-Esco, Katelyn AU - Yuen-Esco K AD - Helen Keller International, NY, United States. FAU - Pries, Alissa M AU - Pries AM AD - Helen Keller International, NY, United States. LA - eng PT - Journal Article DEP - 20240830 PL - United States TA - Curr Dev Nutr JT - Current developments in nutrition JID - 101717957 PMC - PMC12125683 OTO - NOTNLM OT - Demographic and Health Survey OT - cognitive interviewing OT - cognitive validity OT - complementary feeding indicators OT - dietary assessment OT - infant and young child feeding OT - survey measurement COIS- The authors report no conflicts of interest. EDAT- 2025/06/02 06:28 MHDA- 2025/06/02 06:29 PMCR- 2024/08/30 CRDT- 2025/06/02 05:53 PHST- 2024/02/05 00:00 [received] PHST- 2024/05/27 00:00 [revised] PHST- 2024/08/24 00:00 [accepted] PHST- 2025/06/02 06:29 [medline] PHST- 2025/06/02 06:28 [pubmed] PHST- 2025/06/02 05:53 [entrez] PHST- 2024/08/30 00:00 [pmc-release] AID - S2475-2991(24)02387-4 [pii] AID - 104453 [pii] AID - 10.1016/j.cdnut.2024.104453 [doi] PST - epublish SO - Curr Dev Nutr. 2024 Aug 30;9(Suppl 1):104453. doi: 10.1016/j.cdnut.2024.104453. eCollection 2025 Feb. PMID- 40453959 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250603 IS - 2325-9671 (Print) IS - 2325-9671 (Electronic) IS - 2325-9671 (Linking) VI - 13 IP - 5 DP - 2025 May TI - Spanish Translation and Cross-Cultural Adaptation of the Hospital for Special Surgery Pediatric Functional Activity Brief Scale (Spanish HSS Pedi-FABS). PG - 23259671251340987 LID - 10.1177/23259671251340987 [doi] LID - 23259671251340987 AB - BACKGROUND: Language barriers during clinical care are a cause for particular concern for individuals from diverse linguistic backgrounds, especially the Hispanic and Latino US population, who comprise >19% of the American population and speak Spanish, the second most spoken language globally. Ensuring the inclusion of these patients in pediatric sports medicine and rehabilitation research is critical in minimizing bias and necessitates the development of patient-reported outcome measures available for use in Spanish. The Hospital for Special Surgery Pediatric Functional Activity Brief Scale (HSS Pedi-FABS) quantifies activity levels, developed for children and adolescents. PURPOSE: To validate a Spanish-translated and cross-culturally adapted version of the HSS Pedi-FABS questionnaire (Spanish HSS Pedi-FABS). STUDY DESIGN: Cohort study (diagnosis); Level of evidence, 2. METHODS: Phase I consisted of the development and pretesting of the Spanish HSS Pedi-FABS for content validity. Phase II consisted of administering the English and Spanish versions to bilingual children and adolescents aged 10 to 18 years for construct validity and reliability. Participant demographic data and questionnaire responses were recorded. Internal consistency reliability was tested using Cronbach alpha. Construct validity was assessed by calculating a 2-way random-effects model of intraclass correlation coefficient (ICC) between the total scores and each item of the English and Spanish questionnaires. Floor and ceiling effect testing was performed by calculating the proportion of minimum and maximum overall scores in the cohort, respectively, to ensure they did not exceed a 15% threshold. RESULTS: The study included 50 patients with a mean age of 14.1 +/- 2.0 years, of whom 52% were female. Internal consistency reliability of the Spanish HSS Pedi-FABS was excellent (Cronbach alpha = 0.92). Construct validity testing demonstrated excellent agreement between the English and Spanish questionnaires (ICC = 0.91). No floor or ceiling effects were demonstrated by either scale, as the minimum score was observed only twice (4%) in each scale and the maximum score was not observed. CONCLUSION: This study demonstrated that the Spanish HSS Pedi-FABS questionnaire is a valid and reliable tool that physicians can use to quantify physical activity levels in Spanish-speaking pediatric and adolescent populations. The validation of the Spanish HSS Pedi-FABS questionnaire is an important step in ensuring the inclusion of Spanish-speaking patients in pediatric sports medicine and rehabilitation research. CI - (c) The Author(s) 2025. FAU - Jones, Ruth H AU - Jones RH AUID- ORCID: 0009-0006-3097-0747 AD - Hospital for Special Surgery, New York, New York, USA. FAU - Adhiyaman, Akshitha AU - Adhiyaman A AD - Hospital for Special Surgery, New York, New York, USA. AD - Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA. FAU - Gross, Preston W AU - Gross PW AD - SUNY Downstate Health Sciences University College of Medicine, Brooklyn, New York, USA. FAU - Hidalgo Perea, Sofia AU - Hidalgo Perea S AD - Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA. FAU - Green, Daniel W AU - Green DW AUID- ORCID: 0000-0001-7286-6864 AD - Hospital for Special Surgery, New York, New York, USA. FAU - Fabricant, Peter D AU - Fabricant PD AUID- ORCID: 0000-0002-8070-685X AD - Hospital for Special Surgery, New York, New York, USA. LA - eng PT - Journal Article DEP - 20250527 PL - United States TA - Orthop J Sports Med JT - Orthopaedic journal of sports medicine JID - 101620522 PMC - PMC12123146 OTO - NOTNLM OT - HSS Pedi-FABS OT - Spanish HSS Pedi-FABS OT - activity OT - cross-cultural adaptation OT - patient-reported outcome measures OT - pediatric OT - sports medicine OT - translation OT - validation COIS- One or more of the authors has declared the following potential conflict of interest or source of funding: D.W.G. is a board or committee member of AAOS, New York County Medical Society, New York State Society of Orthopedic Surgeons, PatelloFemoral Foundation, Pediatric Orthopaedic Society of North America, and Pediatric Research in Sport Medicine; is a paid presenter or speaker for AO Trauma International and Arthrex Inc; has received IP royalites from Arthrex Inc and Pega Medical; is a paid consultant for Arthrex Inc; receives publishing royalties and financial or material support from Wolters Kluwer Health-Lippincott Williams & Wilkins and Current Opinion in Pediatrics; and is an editorial or governing board member of Current Opinion in Pediatrics. P.D.F. is a paid consultant for BICMD Inc; is an editorial or governing board member of Clinical Orthopaedics and Related Research; has stock or stock options in HS2 LLC, HSS ASC Development Network LLC, Joint Effort Administrative Services Organization LLC, and Osso VR; and receives publishing royalties and financial or material support from Springer. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto. Ethical approval for this study was obtained from Hospital for Special Surgery (IRB No. 2021-0246). EDAT- 2025/06/02 06:28 MHDA- 2025/06/02 06:29 PMCR- 2025/05/27 CRDT- 2025/06/02 05:51 PHST- 2025/01/06 00:00 [received] PHST- 2025/02/12 00:00 [accepted] PHST- 2025/06/02 06:29 [medline] PHST- 2025/06/02 06:28 [pubmed] PHST- 2025/06/02 05:51 [entrez] PHST- 2025/05/27 00:00 [pmc-release] AID - 10.1177_23259671251340987 [pii] AID - 10.1177/23259671251340987 [doi] PST - epublish SO - Orthop J Sports Med. 2025 May 27;13(5):23259671251340987. doi: 10.1177/23259671251340987. eCollection 2025 May. PMID- 40452070 OWN - NLM STAT- MEDLINE DCOM- 20250708 LR - 20250708 IS - 1475-2662 (Electronic) IS - 0007-1145 (Linking) VI - 133 IP - 10 DP - 2025 May 28 TI - Factors associated with meal quality among schoolchildren in three Brazilian cities. PG - 1374-1384 LID - 10.1017/S0007114525103450 [doi] AB - The purpose of this study was to measure meal quality in representative samples of schoolchildren in three cities located in different Brazilian regions using the Meal and Snack Assessment Quality (MESA) scale and examine association with weight status, socio-demographic characteristics and behavioural variables. This cross-sectional study analysed data on 5612 schoolchildren aged 7-12 years who resided in cities in Southern, Southeastern and Northeastern Brazil. Dietary intake was evaluated using the WebCAAFE questionnaire. Body weight and height were measured to calculate the BMI. Weight status was classified based on age- and sex-specific Z-scores. Meal quality was measured using the MESA scale. Associations of meal quality with weight status and socio-demographic and behavioural variables were investigated using multinomial regression analysis. Schoolchildren in Feira de Santana, Sao Paulo and Florianopolis had a predominance of healthy (41.8 %), mixed (44.4 %) and unhealthy (42.7 %) meal quality, respectively. There was no association with weight status. Schoolchildren living in Feira de Santana, those who reported weekday dietary intakes, and those with lower physical activity and screen activity scores showed higher meal quality. Schoolchildren aged 10-12 years, those who reported dietary intakes relative to weekend days, and those with higher screen activity scores exhibited lower meal quality. FAU - Lemke, Stella AU - Lemke S AUID- ORCID: 0000-0002-5503-5038 AD - Federal University of Santa Catarina, Health Sciences Center, Nutrition Postgraduate Program, Florianopolis, Brazil. FAU - de Andrade, Dalton Francisco AU - de Andrade DF AD - Federal University of Santa Catarina, Informatics and Statistics Department, Florianopolis, Brazil. FAU - Hinnig, Patricia de Fragas AU - Hinnig PF AD - Federal University of Santa Catarina, Health Sciences Center, Nutrition Postgraduate Program, Florianopolis, Brazil. FAU - da Silva, Silvio Aparecido AU - da Silva SA AD - Federal Institute of Education, Science and Technology of Santa Catarina, Florianopolis, Brazil. FAU - Kunradi Vieira, Francilene Gracieli AU - Kunradi Vieira FG AD - Federal University of Santa Catarina, Health Sciences Center, Nutrition Postgraduate Program, Florianopolis, Brazil. FAU - de Jesus, Gilmar Merces AU - de Jesus GM AD - State University of Feira de Santana, Feira de Santana, Brazil. FAU - Segura, Iris Emanueli AU - Segura IE AD - Public Health Faculty, University of Sao Paulo, Sao Paulo, Brazil. FAU - Slater, Betzabeth AU - Slater B AD - Public Health Faculty, University of Sao Paulo, Sao Paulo, Brazil. FAU - de Assis, Maria Alice Altenburg AU - de Assis MAA AUID- ORCID: 0000-0002-5383-3714 AD - Federal University of Santa Catarina, Health Sciences Center, Nutrition Postgraduate Program, Florianopolis, Brazil. FAU - Di Pietro, Patricia Faria AU - Di Pietro PF AUID- ORCID: 0000-0003-1343-5049 AD - Federal University of Santa Catarina, Health Sciences Center, Nutrition Postgraduate Program, Florianopolis, Brazil. LA - eng PT - Journal Article DEP - 20250602 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM MH - Humans MH - Brazil MH - Child MH - Male MH - Female MH - Cross-Sectional Studies MH - *Meals MH - *Diet MH - Cities MH - Body Mass Index MH - Surveys and Questionnaires MH - Body Weight MH - Feeding Behavior MH - Socioeconomic Factors MH - Snacks OTO - NOTNLM OT - Diet quality OT - Meals OT - Processed foods OT - Psychometrics EDAT- 2025/06/02 03:18 MHDA- 2025/07/08 12:54 CRDT- 2025/06/01 23:16 PHST- 2025/07/08 12:54 [medline] PHST- 2025/06/02 03:18 [pubmed] PHST- 2025/06/01 23:16 [entrez] AID - S0007114525103450 [pii] AID - 10.1017/S0007114525103450 [doi] PST - ppublish SO - Br J Nutr. 2025 May 28;133(10):1374-1384. doi: 10.1017/S0007114525103450. Epub 2025 Jun 2. PMID- 40450209 OWN - NLM STAT- MEDLINE DCOM- 20250601 LR - 20260623 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 25 IP - 1 DP - 2025 May 31 TI - Sex and age differences in cortisol levels during glucagon stimulation test in children. PG - 440 LID - 10.1186/s12887-025-05784-5 [doi] LID - 440 AB - BACKGROUND: Previous studies of glucagon stimulation test (GST) in children have shown variable results regarding the utility and reliability of the cortisol response to this test and its correlation with clinical parameters. The aim of this study was to assess cortisol levels at GST and to evaluate how clinical parameters, such as age, sex, pubertal status and Body Mass Index (BMI), correlate to cortisol levels in children. METHODS: A retrospective study of children evaluated for short stature with the GST. Cortisol, glucose and growth hormone (GH) levels at GST, as well as clinical parameters (age, sex, pubertal status, BMI), were collected from medical records. A peak cortisol of >/= 450 nmol/L was used as a cut-off indicative of a sufficient response. Non-parametric tests were applied in the statistical analysis, and linear regression was used to examine factors affecting cortisol max at the GST. RESULTS: In total, 171 children were included; median age 7.8 years (1.0-18.0), 60 (35.1%) female, 23 (13.5%) pubertal. Of all children, 145 (84.8%) achieved a peak cortisol >/= 450 nmol/L. There was a negative correlation between peak cortisol levels and age (Spearman's rho - 0.26, p = < 0.001). Peak cortisol levels were higher in females vs. males: 667.5 nmol/L (range 400-995) vs. 602 nmol/L (range 202-1008), p = 0.005. A higher number of boys than girls did not reach the cortisol cut-off value of 450 nmol/L (p = 0.022). The difference in maximum stimulated cortisol levels between the sexes remained after adjusting for age with a linear regression model (beta (95% CI) 65.3 (15.9-114.6), p = 0.01). CONCLUSION: GST is a reliable test of the hypothalamic-pituitary-adrenal (HPA) axis in children. Girls and younger children had higher peak cortisol at GST. The results support a need for sex- and age-dependent reference values for cortisol. CI - (c) 2025. The Author(s). FAU - Borghammar, Camilla AU - Borghammar C AUID- ORCID: 0000-0002-6495-4802 AD - Department of Clinical Sciences, Paediatric Endocrinology, Lund University, Skane University Hospital, Lund, Sweden. camilla.borghammar@med.lu.se. FAU - Svensson, Johan AU - Svensson J AUID- ORCID: 0000-0003-4313-1521 AD - Department of Clinical Sciences, Paediatric Endocrinology, Lund University, Skane University Hospital, Lund, Sweden. AD - Department of Women's and Children's Health, Division of Pediatric Endocrinology, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden. FAU - Tidblad, Anders AU - Tidblad A AUID- ORCID: 0000-0002-5956-6995 AD - Department of Women's and Children's Health, Division of Pediatric Endocrinology, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden. FAU - Elfving, Maria AU - Elfving M AUID- ORCID: 0000-0002-6815-6357 AD - Department of Clinical Sciences, Paediatric Endocrinology, Lund University, Skane University Hospital, Lund, Sweden. LA - eng PT - Journal Article DEP - 20250531 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 RN - WI4X0X7BPJ (Hydrocortisone) RN - 9007-92-5 (Glucagon) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - *Hydrocortisone/blood MH - Male MH - Female MH - Child MH - Retrospective Studies MH - Adolescent MH - *Glucagon/administration & dosage MH - Sex Factors MH - Age Factors MH - Child, Preschool MH - Infant MH - Body Mass Index MH - Puberty MH - Blood Glucose PMC - PMC12125804 OTO - NOTNLM OT - Child OT - Childhood OT - Cortisol OT - Glucagon test OT - Sex-differences COIS- Declarations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. Ethical approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki and was approved by the Swedish Ethical Review Authority (Dnr 2023-05588-01). Data collection from the medical records were approved by the regional consultation group KVB (quality registry, care information systems, and processing) at Region Skane, Sweden and by the Unit Manager at Karolinska University Hospital, Stockholm, Sweden. With these permissions, the Swedish Ethical Review Authority postulated that no written informed consent was required for participation in this study. Study registration details: This study is not a clinical trial; therefore, study registration details (such as the registry, trial registration number, and registration date) are not applicable. EDAT- 2025/06/01 00:45 MHDA- 2025/06/03 00:48 PMCR- 2025/05/31 CRDT- 2025/05/31 23:33 PHST- 2025/02/10 00:00 [received] PHST- 2025/05/20 00:00 [accepted] PHST- 2025/06/03 00:48 [medline] PHST- 2025/06/01 00:45 [pubmed] PHST- 2025/05/31 23:33 [entrez] PHST- 2025/05/31 00:00 [pmc-release] AID - 10.1186/s12887-025-05784-5 [pii] AID - 5784 [pii] AID - 10.1186/s12887-025-05784-5 [doi] PST - epublish SO - BMC Pediatr. 2025 May 31;25(1):440. doi: 10.1186/s12887-025-05784-5. PMID- 40446864 OWN - NLM STAT- MEDLINE DCOM- 20250704 LR - 20260409 IS - 1532-3064 (Electronic) IS - 0954-6111 (Linking) VI - 245 DP - 2025 Aug-Sep TI - The association between alpha-1-acid glycoprotein and asthma in United States: a cross-sectional study from NHANES. PG - 108174 LID - S0954-6111(25)00236-7 [pii] LID - 10.1016/j.rmed.2025.108174 [doi] AB - BACKGROUND: Alpha-1-acid glycoprotein (AGP), also known as orosomucoid (ORM), is an acute-phase protein associated with asthma. However, research on the relationship between AGP and asthma risk is limited. This study aims to investigate the association between AGP and asthma in the United States. METHODS: We used data from the National Health and Nutrition Examination Survey (NHANES) to examine the association between alpha-1-acid glycoprotein and asthma. The main analytical methods used in this study were multivariate logistic regression analysis, restricted cubic spline (RCS) analysis and stratified interaction analysis. RESULTS: This cross-sectional study of 2947 participants (weighted to represent 78,392,391 U S.population) comprised 2746 females (93.8 %) with age distribution of 1150 (30.5 %) aged <20 years and 1797 (69.5 %) aged>/=20 years. When analyzed as a continuous variable and after adjustment for potential confounders, there was a significant positive association between alpha-1-acid glycoprotein and prevalent asthma (OR: 2.81,95 % CI: 1.42-5.57, p < 0.001). However, when alpha-1-acid glycoprotein was divided into tertiles and T1 was used as the reference group, asthma was only positively associated with the T3 group (range of alpha-1-acid glycoprotein: >0.85 g/L). Specifically, each 1 g/L increase in alpha-1-acid glycoprotein increased the risk of asthma by 74 % (95 % CI: 1.08,2.82, p = 0.026). Stratified analyses by sex and socioeconomic status showed similar results. CONCLUSION: In the United States, there is a positive association between higher levels of alpha-1 acid glycoprotein and the risk of asthma. However, more research is needed to explore the underlying mechanisms and to validate these findings in clinical settings. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - Zhang, Xiaolan AU - Zhang X AD - Department of Pediatrics, Third People's Hospital of Liaocheng, No.62, Weiyu Road, Shandong Province, China. Electronic address: zxl2023@stu.sqxy.edu.cn. FAU - Zhang, Xue AU - Zhang X AD - Otolaryngological Department, Affiliated Hospital of Jining Medical University, Jining, 272000, Shandong China. FAU - Wan, Yu AU - Wan Y AD - Department of Pediatrics, Affiliated Hospital of Jining Medical University, Jining, 272000, Shandong, China. FAU - Xu, Dongdong AU - Xu D AD - Department of Pediatrics, Third People's Hospital of Liaocheng, No.62, Weiyu Road, Shandong Province, China. FAU - Han, Yujie AU - Han Y AD - Department of Neonatal, Children's Hospital Affiliated to Shandong University/Jinan Children's Hospital, No. 23976 H Uaiyin District, Jinan, 250022, Shandong, China. Electronic address: 410358192@qq.com. FAU - Zhang, Menmei AU - Zhang M AD - Department of Pediatrics, Affiliated Hospital of Jining Medical University, No. 89, Guhuai Road, Shandong Province, China. Electronic address: zmmei1107@126.com. LA - eng PT - Journal Article DEP - 20250528 PL - England TA - Respir Med JT - Respiratory medicine JID - 8908438 RN - 0 (Orosomucoid) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Asthma/epidemiology/blood MH - *Orosomucoid/metabolism/analysis MH - Female MH - Cross-Sectional Studies MH - Male MH - United States/epidemiology MH - Adult MH - Nutrition Surveys MH - Middle Aged MH - Young Adult MH - Risk Factors MH - Prevalence MH - Adolescent MH - Aged MH - Biomarkers/blood OTO - NOTNLM OT - Alpha-1-acid glycoprotein OT - Asthma OT - Cross-sectional study COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/05/31 00:36 MHDA- 2025/07/05 00:28 CRDT- 2025/05/30 19:31 PHST- 2025/02/13 00:00 [received] PHST- 2025/05/16 00:00 [revised] PHST- 2025/05/21 00:00 [accepted] PHST- 2025/07/05 00:28 [medline] PHST- 2025/05/31 00:36 [pubmed] PHST- 2025/05/30 19:31 [entrez] AID - S0954-6111(25)00236-7 [pii] AID - 10.1016/j.rmed.2025.108174 [doi] PST - ppublish SO - Respir Med. 2025 Aug-Sep;245:108174. doi: 10.1016/j.rmed.2025.108174. Epub 2025 May 28. PMID- 40446144 OWN - NLM STAT- MEDLINE DCOM- 20250530 LR - 20250530 IS - 1753-4887 (Electronic) IS - 0029-6643 (Linking) VI - 83 IP - Supplement_1 DP - 2025 May 1 TI - Development and Validation of the Global Diet Quality Score (GDQS) for Children 24 to 59 Months of Age. PG - 17-36 LID - 10.1093/nutrit/nuaf005 [doi] AB - OBJECTIVES: To develop the Global Diet Quality Score (GDQS) for children aged 24-59 months and evaluate its performance in predicting outcomes related to nutrient adequacy and diet-related noncommunicable disease (NCD) risk. BACKGROUND: The GDQS is a food-based metric developed and validated for capturing diets' contributions to nutrient adequacy and NCD risk among adult men and nonpregnant and nonlactating women aged >/=15 years globally. Despite the importance of ensuring healthy diets in preschool children and the need for systematic monitoring, no food-based metrics exist that holistically measure diet quality among children aged 24-59 months in diverse populations. METHODS: We developed candidate versions of the GDQS for children aged 24-59 months by adapting the gram cutoff values used for adults to account for children's lower energy requirements. Using dietary data sets from Bangladesh, Burkina Faso, China, Ethiopia, Mexico, the United Kingdom, and the United States, we evaluated candidate versions' performance in predicting energy-adjusted nutrient intakes and adequacy, nutritional biomarkers, and overweight using Spearman's correlation and multivariable-adjusted regression models, and we statistically compared performance of the strongest candidate with that of the Minimum Dietary Diversity-Women (MDD-W) indicator and Global Dietary Recommendations (GDR) score. RESULTS: The GDQS exhibited significant (P < .05) positive correlations with energy-adjusted intakes of protein, fiber, and most micronutrients in most data sets; significant negative correlations with added sugar and saturated fat in 2 data sets; and inconsistent correlations with monounsaturated and polyunsaturated fat. In multivariable-adjusted models, the GDQS, MDD-W, and GDR were positively associated with serum folate in Ethiopia (and the GDQS was in the United Kingdom), and the GDR was positively associated with high-density lipoprotein cholesterol in China (P < .05). The GDQS was more strongly associated with the mean probability of adequacy of 8 nutrients than the GDR in 2 data sets, whereas the MDD-W outperformed the GDQS in 3 data sets (P < .05). CONCLUSION: The GDQS is a useful metric for measuring diet quality among children aged 24-59 months in diverse populations. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Ali, Nazia Binte AU - Ali NB AUID- ORCID: 0000-0001-5010-9563 AD - Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. AD - Maternal and Child Health Division, International Center for Diarrhoeal Disease Research, Bangladesh, Dhaka 1212, Bangladesh. FAU - Arsenault, Joanne E AU - Arsenault JE AUID- ORCID: 0000-0002-9580-0320 AD - Intake Center for Dietary Assessment, FHI 360, Washington, DC 20037, United States. FAU - Castellanos-Gutierrez, Anali AU - Castellanos-Gutierrez A AUID- ORCID: 0000-0002-7256-6842 AD - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. FAU - Moursi, Mourad AU - Moursi M AUID- ORCID: 0000-0002-5071-8534 AD - Intake Center for Dietary Assessment, FHI 360, Washington, DC 20037, United States. FAU - Deitchler, Megan AU - Deitchler M AUID- ORCID: 0009-0001-1170-2564 AD - Intake Center for Dietary Assessment, FHI 360, Washington, DC 20037, United States. FAU - Batis, Carolina AU - Batis C AUID- ORCID: 0000-0002-2823-6651 AD - Health and Nutrition Research Center, National Institute of Public Health, Cuernavaca, Morelos 62100, Mexico. FAU - Atayde, Agata Marina Perez AU - Atayde AMP AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. FAU - Kehoe, Sarah H AU - Kehoe SH AUID- ORCID: 0000-0003-2584-7999 AD - MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton SO16 6YD, United Kingdom. FAU - Tadesse, Amare W AU - Tadesse AW AUID- ORCID: 0000-0002-7805-3191 AD - Department of Infectious Disease Epidemiology and International Health, London School of Hygiene & Tropical Medicine, London WC1E 7HT, United Kingdom. FAU - Leonardo, Sofia AU - Leonardo S AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. FAU - Nkengfack, Brunhilda Tegomoh AU - Nkengfack BT AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. FAU - Diop, Loty AU - Diop L AUID- ORCID: 0000-0002-3131-9108 AD - International Food Policy Research Institute, Dakar BP 24063, Senegal. FAU - Gelli, Aulo AU - Gelli A AUID- ORCID: 0000-0003-4977-2549 AD - International Food Policy Research Institute, Washington, DC 20005, United States. FAU - Fawzi, Wafaie W AU - Fawzi WW AD - Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. AD - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. FAU - Willett, Walter C AU - Willett WC AD - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. FAU - Bromage, Sabri AU - Bromage S AUID- ORCID: 0000-0002-6552-4871 AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. AD - Community Nutrition Unit, Institute of Nutrition, Mahidol University, Salaya, Phutthamonthon, Nakhon Pathom 73170, Thailand. LA - eng GR - Validation of the Global Diet Quality Score/ GR - Metric of Diet Quality for Children 2 to 14 Years of Age/ GR - 2021 FOD 024/The Rockefeller Center/ GR - GATES/Gates Foundation/United States PT - Journal Article PT - Validation Study PL - United States TA - Nutr Rev JT - Nutrition reviews JID - 0376405 SB - IM MH - Humans MH - Child, Preschool MH - Female MH - Male MH - *Diet/standards MH - *Diet, Healthy MH - Global Health MH - *Nutrition Assessment MH - Energy Intake OTO - NOTNLM OT - GDQS OT - diet quality metrics OT - noncommunicable disease OT - nutrient adequacy OT - preschool children EDAT- 2025/05/30 18:52 MHDA- 2025/05/30 18:53 CRDT- 2025/05/30 15:22 PHST- 2025/05/30 18:53 [medline] PHST- 2025/05/30 18:52 [pubmed] PHST- 2025/05/30 15:22 [entrez] AID - 8154118 [pii] AID - 10.1093/nutrit/nuaf005 [doi] PST - ppublish SO - Nutr Rev. 2025 May 1;83(Supplement_1):17-36. doi: 10.1093/nutrit/nuaf005. PMID- 40446142 OWN - NLM STAT- MEDLINE DCOM- 20250730 LR - 20250730 IS - 1753-4887 (Electronic) IS - 0029-6643 (Linking) VI - 83 IP - Supplement_1 DP - 2025 May 1 TI - Development and Validation of the Global Diet Quality Score (GDQS) for Children 5 to 9 Years of Age. PG - 37-49 LID - 10.1093/nutrit/nuae146 [doi] AB - OBJECTIVE: The purpose of the study was to develop and validate a Global Diet Quality Score (GDQS) for children aged 5-9 years adapted from the existing GDQS developed for adults. BACKGROUND: Diet quality is important for nutrient adequacy and risk of nutrition-related chronic disease. A diet quality metric for global use with children is needed. METHODS: The 25 food groups of the GDQS were used to assign points for categories of consumption according to gram-weight cutoffs adapted for children based on energy requirements. As a preliminary step, alternative versions of gram-weight cutoffs were tested by comparing correlation analyses using 4 existing dietary datasets from low-, middle-, and high-income countries. A final GDQS metric version, selected based on strength of correlations and operational feasibility, was further examined in regression analyses with individual nutrient intake an overall nutrient intake adequacy score and biomarker and anthropometry outcomes in 7 dietary datasets from different countries. Regressions were also undertaken with other diet quality metrics to compare their relative performance with that of the GDQS. RESULTS: The GDQS had strong associations with most nutrient intakes, including an overall mean nutrient adequacy score and some nutrients associated with noncommunicable disease risk, such as fiber and added sugar. Biomarker data were limited in the available datasets and few associations with GDQS were found. The GDQS performed better or as well as other dietary quality metrics in predicting nutrient intakes. CONCLUSION: The GDQS was associated with nutrient intakes and fills a gap in a global diet quality metric for children. The GDQS will be a useful tool to measure diet quality and monitoring changes in diet quality over time. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Arsenault, Joanne E AU - Arsenault JE AUID- ORCID: 0000-0002-9580-0320 AD - Intake-Center for Dietary Assessment, FHI 360, Washington, DC 20037, United States. FAU - Ali, Nazia Binte AU - Ali NB AUID- ORCID: 0000-0001-5010-9563 AD - Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. FAU - Atayde, Agata M P AU - Atayde AMP AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. FAU - Batis, Carolina AU - Batis C AUID- ORCID: 0000-0002-2823-6651 AD - National Institute of Public Health, Health and Nutrition Research Center, Cuernavaca, Morelos, Mexico. FAU - Becquey, Elodie AU - Becquey E AUID- ORCID: 0000-0002-8748-7637 AD - Nutrition, Diet, and Health Unit, International Food Policy Research Institute, Washington, DC 20005, United States. FAU - Bromage, Sabri AU - Bromage S AUID- ORCID: 0000-0002-6552-4871 AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. AD - Community Nutrition Unit, Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand. FAU - Deitchler, Megan AU - Deitchler M AUID- ORCID: 0009-0001-1170-2564 AD - Intake-Center for Dietary Assessment, FHI 360, Washington, DC 20037, United States. FAU - Diop, Loty AU - Diop L AUID- ORCID: 0000-0002-3131-9108 AD - Nutrition, Diet, and Health Unit, International Food Policy Research Institute, Dakar, Senegal. FAU - Gelli, Aulo AU - Gelli A AUID- ORCID: 0000-0003-4977-2549 AD - Poverty, Gender, and Inclusion Unit, International Food Policy Research Institute, Washington, DC 20005, United States. FAU - Castellanos Gutierrez, Anali AU - Castellanos Gutierrez A AUID- ORCID: 0000-0002-7256-6842 AD - Epidemiology Department, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. FAU - Kehoe, Sarah H AU - Kehoe SH AUID- ORCID: 0000-0003-2584-7999 AD - MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, United Kingdom. FAU - Krishnaveni, Ghattu V AU - Krishnaveni GV AUID- ORCID: 0000-0002-6532-8272 AD - Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, Mysore, Karnataka, India. FAU - Leonardo, Sofia AU - Leonardo S AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. FAU - Moursi, Mourad AU - Moursi M AUID- ORCID: 0000-0002-5071-8534 AD - Intake-Center for Dietary Assessment, FHI 360, Washington, DC 20037, United States. FAU - Nkengfack, Brunhilda Tegomoh AU - Nkengfack BT AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. LA - eng GR - Validation of the Global Diet Quality Score/ GR - Metric of Diet Quality for Children 2 to 14 Years of Age/ GR - 2021 FOD 024/The Rockefeller Center/ GR - GATES/Gates Foundation/United States PT - Journal Article PT - Validation Study PL - United States TA - Nutr Rev JT - Nutrition reviews JID - 0376405 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Child, Preschool MH - Child MH - *Diet Surveys MH - *Global Health MH - Anthropometry MH - Eating MH - Biomarkers/blood OTO - NOTNLM OT - GDQS OT - NCD OT - children OT - diet quality OT - dietary intake OT - nutrient adequacy EDAT- 2025/05/30 18:52 MHDA- 2025/05/30 18:53 CRDT- 2025/05/30 15:22 PHST- 2025/05/30 18:53 [medline] PHST- 2025/05/30 18:52 [pubmed] PHST- 2025/05/30 15:22 [entrez] AID - 8154116 [pii] AID - 10.1093/nutrit/nuae146 [doi] PST - ppublish SO - Nutr Rev. 2025 May 1;83(Supplement_1):37-49. doi: 10.1093/nutrit/nuae146. PMID- 40446141 OWN - NLM STAT- MEDLINE DCOM- 20250530 LR - 20250530 IS - 1753-4887 (Electronic) IS - 0029-6643 (Linking) VI - 83 IP - Supplement_1 DP - 2025 May 1 TI - Validation of the Global Diet Quality Score (GDQS) Among Children 10 to 14 Years of Age. PG - 50-60 LID - 10.1093/nutrit/nuaf006 [doi] AB - OBJECTIVE: We aimed to evaluate the performance of the Global Diet Quality Score (GDQS) in predicting nutrient intake and health outcomes among children aged 10-14 years old in Mexico, the United States, the United Kingdom, and China. For comparison, we evaluated other dietary metrics (Minimum Dietary Diversity for Women [MDD-W], the Global Dietary Recommendations score [GDR], and the Healthy Eating Index-2020 [HEI-2020]). BACKGROUND: Given the magnitude of the health burden associated with all forms of malnutrition, monitoring dietary quality is fundamental to improving global health. Early adolescence is a key stage of development, and thus validated tools to measure diet quality that are pertinent for the global context are needed. METHODS: The GDQS and comparison metrics were estimated from 24-hour dietary recalls (Mexico: n = 2533; United States: n = 685; China: n = 1087, and United Kingdom: n = 1675). Regression models were conducted to evaluate the association between the change in 1 SD of each metric score and usual intake of nutrients, mean probability of nutrient adequacy, and biomarker and anthropometric outcomes adjusted by age, sex, socioeconomic status, educational level, urban/rural area, and usual energy intake (for dietary outcomes). RESULTS: The GDQS showed a higher diet quality in China (16.7 points) and Mexico (15.9 points), followed by the United States (13.6 points) and the United Kingdom (12.2 points). The GDQS was found to be associated with the intake of micronutrients as well as noncommunicable disease (NCD)-related nutrients (fiber, added sugar, and saturated fat) (P < .05). The performance of the GDQS was comparable to all other metrics; yet, in the case of NCD-related nutrients the MDD-W was slightly inferior. Few associations were found across countries and metrics with biomarker and anthropometric outcomes. CONCLUSION: The GDQS was associated with the intake of micronutrients and NCD-related nutrients; these results suggest that the GDQS is an appropriate tool to monitor dietary quality among 10-14-year-olds across several contexts globally. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Batis, Carolina AU - Batis C AUID- ORCID: 0000-0002-2823-6651 AD - National Institute of Public Health, Health and Nutrition Research Center, Cuernavaca, Morelos 62100, Mexico. FAU - Castellanos-Gutierrez, Anali AU - Castellanos-Gutierrez A AUID- ORCID: 0000-0002-7256-6842 AD - Epidemiology Department, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. FAU - Ali, Nazia Binte AU - Ali NB AUID- ORCID: 0000-0001-5010-9563 AD - Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. FAU - Arsenault, Joanne E AU - Arsenault JE AUID- ORCID: 0000-0002-9580-0320 AD - Intake-Center for Dietary Assessment, FHI 360, Washington, DC 20037, United States. FAU - Atayde, Agata M P AU - Atayde AMP AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. FAU - Bromage, Sabri AU - Bromage S AUID- ORCID: 0000-0002-6552-4871 AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. AD - Community Nutrition Unit, Institute of Nutrition, Mahidol University, Salaya, Phutthamonthon, Nakhon Pathom 73170, Thailand. FAU - Deitchler, Megan AU - Deitchler M AUID- ORCID: 0009-0001-1170-2564 AD - Intake-Center for Dietary Assessment, FHI 360, Washington, DC 20037, United States. FAU - Diop, Loty AU - Diop L AUID- ORCID: 0000-0002-3131-9108 AD - International Food Policy Research Institute, Dakar 24063, Senegal. FAU - Gelli, Aulo AU - Gelli A AUID- ORCID: 0000-0003-4977-2549 AD - International Food Policy Research Institute, Washington, DC 20005-3915, United States. FAU - Kehoe, Sarah H AU - Kehoe SH AUID- ORCID: 0000-0003-2584-7999 AD - MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton SO17 1BJ, United Kingdom. FAU - Leonardo, Sofia AU - Leonardo S AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. FAU - Moursi, Mourad AU - Moursi M AUID- ORCID: 0000-0002-5071-8534 AD - Intake-Center for Dietary Assessment, FHI 360, Washington, DC 20037, United States. FAU - Nkengfack, Brunhilda Tegomoh AU - Nkengfack BT AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. FAU - Willett, Walter C AU - Willett WC AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. LA - eng GR - Validation of the Global Diet Quality Score/ GR - Metric of Diet Quality for Children 2 to 14 Years of Age/ GR - GATES/Gates Foundation/United States PT - Journal Article PT - Validation Study PL - United States TA - Nutr Rev JT - Nutrition reviews JID - 0376405 SB - IM MH - Humans MH - Child MH - Adolescent MH - Female MH - United Kingdom MH - Male MH - *Diet/standards MH - Mexico MH - China MH - United States MH - *Diet, Healthy MH - Global Health MH - *Diet Surveys MH - Nutrition Assessment MH - Nutritional Status OTO - NOTNLM OT - GDQS OT - NCD OT - adolescents OT - children OT - diet quality OT - dietary intake OT - nutrient adequacy OT - nutrient intake EDAT- 2025/05/30 18:52 MHDA- 2025/05/30 18:53 CRDT- 2025/05/30 15:22 PHST- 2025/05/30 18:53 [medline] PHST- 2025/05/30 18:52 [pubmed] PHST- 2025/05/30 15:22 [entrez] AID - 8154113 [pii] AID - 10.1093/nutrit/nuaf006 [doi] PST - ppublish SO - Nutr Rev. 2025 May 1;83(Supplement_1):50-60. doi: 10.1093/nutrit/nuaf006. PMID- 40446138 OWN - NLM STAT- MEDLINE DCOM- 20250530 LR - 20250530 IS - 1753-4887 (Electronic) IS - 0029-6643 (Linking) VI - 83 IP - Supplement_1 DP - 2025 May 1 TI - Development and Validation of Metrics of Diet, Menu, and Meal Quality for Children 2 to 14 Years of Age: Overview. PG - 1-16 LID - 10.1093/nutrit/nuae125 [doi] AB - OBJECTIVE: To describe the motivation for undertaking research to validate the Global Diet Quality Score (GDQS) for use among children 2-14 years of age, and to summarize results from the GDQS child validation research initiative presented in this Supplemental Issue. BACKGROUND: To advance an agenda to address diet quality among children globally requires the availability of diet quality metrics that meet the following 5 criteria: (1) cross-country relevance; (2) cross-country validity; (3) compatibility with the use of low-cost data collection methods; (4) straightforward tabulation methods; and (5) provides a whole-of-diet measure. No existing metric meets all 5 criteria. The research in this Supplement aims to fill this gap. METHODS: The GDQS was adapted for 3 different age groups (24-59 months, 5-9 years, and 10-14 years) and validated for predicting nutrient adequacy and noncommunicable disease (NCD)-related outcomes by analyzing cross-sectional dietary data from a diverse set of countries. Longitudinal associations between the GDQS and NCD-related outcomes were also evaluated. RESULTS: Validation results show the GDQS is positively associated with energy-adjusted intakes of micronutrients and fiber, and negatively associated with energy-adjusted intakes of added sugar in most data sets. In longitudinal analyses, the GDQS was negatively associated with several adiposity and cardiometabolic outcomes. CONCLUSION: To routinely measure the quality of diets of children globally requires a new set of tools. The research in this Supplement helps fill this gap by describing work to develop and validate the GDQS for use among children 2-14 years of age, using data sets from diverse contexts across low-, middle-, and high-income countries. The research also fills a gap in the availability of a standardized metric for assessing the quality of meals and menus in institutional feeding settings by applying the GDQS validated for children to the development of a GDQS-Meal and Menu metric. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Deitchler, Megan AU - Deitchler M AUID- ORCID: 0009-0001-1170-2564 AD - Intake-Center for Dietary Assessment, FHI 360, Washington, DC 20037, USA. FAU - Batis, Carolina AU - Batis C AUID- ORCID: 0000-0002-2823-6651 AD - Health and Nutrition Research Center, National Institute of Public Health, Cuernavaca, Morelos, Mexico. FAU - Bromage, Sabri AU - Bromage S AUID- ORCID: 0000-0002-6552-4871 AD - Community Nutrition Unit, Institute of Nutrition, Mahidol University, Salaya, Phutthamonthon, Nakhon Pathom, Thailand. AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. FAU - Arsenault, Joanne E AU - Arsenault JE AUID- ORCID: 0000-0002-9580-0320 AD - Intake-Center for Dietary Assessment, FHI 360, Washington, DC 20037, USA. LA - eng GR - Validation of the Global Diet Quality Score/ GR - Metric of Diet Quality for Children 2 to 14 Years of Age/ GR - 2021 FOD 024/The Rockefeller Center/ GR - GATES/Gates Foundation/United States PT - Journal Article PL - United States TA - Nutr Rev JT - Nutrition reviews JID - 0376405 SB - IM MH - Humans MH - Child MH - Adolescent MH - Child, Preschool MH - *Diet/standards MH - *Meals MH - Reproducibility of Results MH - Male MH - Female MH - Diet Surveys OTO - NOTNLM OT - GDQS OT - NCD OT - children OT - diet quality OT - dietary intake OT - nutrient adequacy OT - nutrient intake EDAT- 2025/05/30 18:52 MHDA- 2025/05/30 18:53 CRDT- 2025/05/30 15:22 PHST- 2025/05/30 18:53 [medline] PHST- 2025/05/30 18:52 [pubmed] PHST- 2025/05/30 15:22 [entrez] AID - 8154109 [pii] AID - 10.1093/nutrit/nuae125 [doi] PST - ppublish SO - Nutr Rev. 2025 May 1;83(Supplement_1):1-16. doi: 10.1093/nutrit/nuae125. PMID- 40445735 OWN - NLM STAT- MEDLINE DCOM- 20250804 LR - 20250804 IS - 2191-0251 (Electronic) IS - 0334-018X (Linking) VI - 38 IP - 8 DP - 2025 Aug 26 TI - Is L-dopa test effective in detecting adrenal insufficiency with preliminary diagnosis of growth hormone deficiency in children with short stature? PG - 824-829 LID - 10.1515/jpem-2025-0143 [doi] AB - OBJECTIVES: Growth hormone (GH) deficiency in children is characterized by impaired linear growth and reduced growth velocity, necessitating confirmation through two GH stimulation tests. At the time of diagnosis, approximately 4 % of children with GH deficiency exhibit concomitant adrenocorticotropic hormone (ACTH) deficiency, a prevalence that increases to 12 % over the course of follow-up. The insulin tolerance test is regarded as the gold standard for assessing both cortisol and GH secretion; however, its clinical application is constrained by potential risks and the requirement for close medical supervision. This study aims to evaluate the effect of the L-dopa stimulation test on cortisol secretion in pediatric patients with short stature. METHODS: This retrospective study included 138 children (65 females, 73 males) who underwent the L-dopa stimulation test for the assessment of GH deficiency at the Pediatric Endocrinology Clinic between January 2010 and December 2023. Serum cortisol concentrations were measured at the 90th and 120th min of the test. Patients with a peak cortisol response <18 mug/dL subsequently underwent a low-dose (1 mug) ACTH stimulation test to further evaluate adrenal function. Clinical, anthropometric, and biochemical data were extracted from medical records and subjected to statistical analysis. RESULTS: The mean age of the study cohort was 9.34 +/- 3.79 years, with 65 (47.1 %) female and 73 (52.9 %) male patients. The mean height standard deviation score (SDS) was -2.62 +/- 0.83, while the mean weight SDS was -1.81 +/- 1.09. The mean peak GH response was 5.64 +/- 4.0 ng/mL following the clonidine stimulation test and 7.29 +/- 5.23 ng/mL following the L-dopa test. A total of 35 children exhibited a peak cortisol response <18 mug/dL during the L-dopa test. Among these, 35 underwent a low-dose (1 mug) ACTH stimulation test, and 7 patients (20 % of those tested; 5.1 % of the total cohort) were diagnosed with adrenal insufficiency, defined as a peak cortisol response <18 mug/dL. These patients were initiated on oral hydrocortisone therapy. Comparative analyses between patients with normal vs. impaired ACTH test responses (<18 mug/dL vs. >/=18 mug/dL) revealed no statistically significant differences in peak cortisol response to the L-dopa test, peak GH response to clonidine or L-dopa, age at presentation, gender, weight SDS, or height SDS. CONCLUSIONS: The L-dopa stimulation test may represent a valuable adjunctive tool for the evaluation of cortisol sufficiency in children undergoing assessment for suspected GH deficiency. However, further prospective studies with larger sample sizes and standardized protocols are warranted to validate its diagnostic accuracy and clinical utility in detecting adrenal insufficiency. CI - (c) 2025 Walter de Gruyter GmbH, Berlin/Boston. FAU - Vural Topaktas, Gulumay AU - Vural Topaktas G AUID- ORCID: 0000-0001-8996-1251 AD - Pediatric Endocrinology Clinic, Izmir City Hospital, Izmir, Turkiye. FAU - Er, Eren AU - Er E AUID- ORCID: 0000-0003-4770-0365 AD - Pediatric Endocrinology Clinic, Izmir City Hospital, Izmir, Turkiye. FAU - Onguner, Sevim AU - Onguner S AD - Pediatric Endocrinology Clinic, Izmir City Hospital, Izmir, Turkiye. FAU - Turan, Benay AU - Turan B AD - Pediatric Endocrinology Clinic, Izmir City Hospital, Izmir, Turkiye. FAU - Dundar, Bumin Nuri AU - Dundar BN AD - Faculty of Medicine, Department of Pediatric Endocrinology, Izmir Katip Celebi University, Izmir, Turkiye. LA - eng PT - Journal Article DEP - 20250529 PL - Germany TA - J Pediatr Endocrinol Metab JT - Journal of pediatric endocrinology & metabolism : JPEM JID - 9508900 RN - 12629-01-5 (Human Growth Hormone) RN - 46627O600J (Levodopa) RN - WI4X0X7BPJ (Hydrocortisone) RN - 9002-60-2 (Adrenocorticotropic Hormone) SB - IM MH - Humans MH - Female MH - Male MH - Retrospective Studies MH - *Adrenal Insufficiency/diagnosis/blood/etiology MH - Child MH - *Human Growth Hormone/deficiency MH - *Levodopa MH - Hydrocortisone/blood MH - Adolescent MH - Body Height MH - *Growth Disorders/diagnosis MH - Follow-Up Studies MH - Prognosis MH - Child, Preschool MH - Adrenocorticotropic Hormone OTO - NOTNLM OT - L-dopa OT - adrenal function OT - adrenal insufficiency OT - cortisol OT - cortisol deficiency OT - dopamine agonist EDAT- 2025/05/30 18:53 MHDA- 2025/08/04 18:28 CRDT- 2025/05/30 12:13 PHST- 2025/03/15 00:00 [received] PHST- 2025/05/18 00:00 [accepted] PHST- 2025/08/04 18:28 [medline] PHST- 2025/05/30 18:53 [pubmed] PHST- 2025/05/30 12:13 [entrez] AID - jpem-2025-0143 [pii] AID - 10.1515/jpem-2025-0143 [doi] PST - epublish SO - J Pediatr Endocrinol Metab. 2025 May 29;38(8):824-829. doi: 10.1515/jpem-2025-0143. Print 2025 Aug 26. PMID- 40444548 OWN - NLM STAT- MEDLINE DCOM- 20250530 LR - 20250530 IS - 1442-200X (Electronic) IS - 1328-8067 (Linking) VI - 67 IP - 1 DP - 2025 Jan-Dec TI - Validation of the peripherally inserted central venous catheter insertion length prediction formula using height in children. PG - e70100 LID - 10.1111/ped.70100 [doi] AB - BACKGROUND: Placing the tip of the peripherally inserted central catheter (PICC) in the appropriate range is important, but most difficult without fluoroscopy. The aim of this study was to test the validity of the PICC insertion length prediction formula "length from anterior axillary point to appropriate PICC tip position = height (cm) x 0.1 + 1 (cm)" METHODS: This study retrospectively compared PICCs inserted through the upper arm in a pediatric intensive care unit before (the No-formula group, May 2017-September 2018) and after (the Formula group, May 2021-December 2021). We excluded PICCs inserted in patients older than 15 years of age and those with anatomical abnormalities or diseases, or PICCs inserted without using the formula in the Formula group. The primary outcome was the proportion of PICCs with appropriate tip positions (superior vena cava or subclavian vein) visualized on chest radiographs immediately after insertion. RESULTS: There were 148 PICCs in the No-formula group and 47 PICCs in the Formula group for the primary analysis. Appropriate tip position was observed significantly more often in the Formula group (98%, 46/47) compared to the No-formula group (65%, 96/148) (p < 0.001). Although there were no shallow PICCs, PICC tips in the subclavian vein were more frequent in the Formula group (26% vs. 9%, p = 0.012). CONCLUSIONS: The PICC insertion length prediction formula could reduce excessive deep tip positioning, but further measures are required to enhance tip placement in the superior vena cava. CI - (c) 2025 Japan Pediatric Society. FAU - Okuwaki, Hajime AU - Okuwaki H AUID- ORCID: 0000-0002-6151-3016 AD - Critical Care Medicine, National Center for Child Health and Development, Tokyo, Japan. AD - Pediatrics, University of Tsukuba Hospital, Ibaraki, Japan. FAU - Ide, Kentaro AU - Ide K AUID- ORCID: 0000-0003-3142-0764 AD - Critical Care Medicine, National Center for Child Health and Development, Tokyo, Japan. FAU - Ota, Hidehito AU - Ota H AD - Critical Care Medicine, National Center for Child Health and Development, Tokyo, Japan. AD - Department of Pediatrics, The University of Tokyo, Tokyo, Japan. FAU - Tokuda, Yusuke AU - Tokuda Y AUID- ORCID: 0000-0003-4220-6798 AD - Critical Care Medicine, National Center for Child Health and Development, Tokyo, Japan. FAU - Nakagawa, Satoshi AU - Nakagawa S AD - Critical Care Medicine, National Center for Child Health and Development, Tokyo, Japan. LA - eng GR - 2023C-8/National Center for Child Health and Development/ PT - Journal Article PT - Validation Study PL - Australia TA - Pediatr Int JT - Pediatrics international : official journal of the Japan Pediatric Society JID - 100886002 SB - IM MH - Humans MH - Retrospective Studies MH - Male MH - Female MH - *Catheterization, Peripheral/methods MH - Child MH - *Catheterization, Central Venous/methods MH - Child, Preschool MH - Infant MH - *Body Height MH - Central Venous Catheters MH - Intensive Care Units, Pediatric MH - Subclavian Vein/diagnostic imaging MH - Vena Cava, Superior/diagnostic imaging MH - Adolescent OTO - NOTNLM OT - central venous catheters OT - child OT - height OT - peripherally inserted central venous catheter OT - prediction formula EDAT- 2025/05/30 17:55 MHDA- 2025/05/30 17:56 CRDT- 2025/05/30 06:23 PHST- 2025/03/10 00:00 [revised] PHST- 2024/07/25 00:00 [received] PHST- 2025/04/21 00:00 [accepted] PHST- 2025/05/30 17:56 [medline] PHST- 2025/05/30 17:55 [pubmed] PHST- 2025/05/30 06:23 [entrez] AID - 10.1111/ped.70100 [doi] PST - ppublish SO - Pediatr Int. 2025 Jan-Dec;67(1):e70100. doi: 10.1111/ped.70100. PMID- 40443729 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250601 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 16 DP - 2025 TI - The impact of physical activity on adolescent mental health status: the mediating effect of school adaptation. PG - 1573129 LID - 10.3389/fpsyg.2025.1573129 [doi] LID - 1573129 AB - OBJECTIVE: This study was designed to examine the mental health status of Chinese adolescents, investigate the effects of adolescent physical activity on mental health status, and verify the mediating effect of school adaptation. METHODS: A survey and analysis were conducted on 9,701 high school students in Shandong Province using the Physical Activity Questionnaire for Adolescents (PAQ-A), the School Social Behavior Scale-2 (SSBS-2), and the Symptom Checklist-90 (SCL-90) self-rating scale. The overall status of adolescent mental health was analyzed, regression modeling along with structural equation modeling was used to test whether school adaptation played a mediating role. RESULTS: The structural equation model was validated as a good fit (GFI = 0.950, RMSEA = 0.048, CFI = 0.972, NFI = 0.970, SRMR = 0.077). Physical activity was significantly and positively correlated with mental health status (beta = -0.691, p < 0.001), school adaptation (beta = 1.153, p < 0.001), and school adaptation was significantly and positively correlated with mental health status (beta = -0.287, p < 0.001). The direct effect of physical activity on mental health status was 0.011 and the indirect effect of physical activity on school adaptation and school adaptation on mental health status was 0.024. CONCLUSION: Physical activity was positively related to mental health status, with physical activity significantly and positively predicting mental health status; school adaptation was significantly and positively related to physical activity and mental health status, with school adaptation mediating between physical activity and mental health status. CI - Copyright (c) 2025 Zhang, Gu, Zeng and Yi. FAU - Zhang, Menghan AU - Zhang M AD - School of Education, Nanning University, Nanning, China. AD - School of Physical Education, Guangxi University, Nanning, China. FAU - Gu, Chenguang AU - Gu C AD - School of Education, Nanning University, Nanning, China. FAU - Zeng, Hui AU - Zeng H AD - School of Physical Education, Shandong University, Jinan, China. FAU - Yi, Xiangren AU - Yi X AD - School of Physical Education, Shandong University, Jinan, China. LA - eng PT - Journal Article DEP - 20250515 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC12119619 OTO - NOTNLM OT - adolescents OT - mental health status OT - physical activity OT - school adaptation OT - structural equation modeling COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/05/30 07:57 MHDA- 2025/05/30 07:58 PMCR- 2025/05/15 CRDT- 2025/05/30 04:28 PHST- 2025/02/08 00:00 [received] PHST- 2025/05/02 00:00 [accepted] PHST- 2025/05/30 07:58 [medline] PHST- 2025/05/30 07:57 [pubmed] PHST- 2025/05/30 04:28 [entrez] PHST- 2025/05/15 00:00 [pmc-release] AID - 10.3389/fpsyg.2025.1573129 [doi] PST - epublish SO - Front Psychol. 2025 May 15;16:1573129. doi: 10.3389/fpsyg.2025.1573129. eCollection 2025. PMID- 40443306 OWN - NLM STAT- Publisher LR - 20250530 IS - 2211-9132 (Print) IS - 2211-9132 (Linking) DP - 2025 May 21 TI - External validation of the international immunoglobulin A nephropathy (IgAN) prediction tool in Korean children with IgAN. LID - 10.23876/j.krcp.24.262 [doi] AB - BACKGROUND: The International IgA nephropathy (IgAN) Prediction Tool was recently updated to predict the risk of a 30% decline in estimated glomerular filtration rate (eGFR) or kidney failure in children with IgAN. We aimed to evaluate the clinical performance of this tool in a Korean cohort of children with IgAN. METHODS: We calculated the predicted risk for biopsy-proven IgAN children from 20 Korean centers. The primary outcome was a 30% decline in eGFR or kidney failure. Discrimination and calibration performances of two pre-developed models were first evaluated. Subsequently, we constructed an updated model for Korean children using clinically meaningful variables. RESULTS: The study included 472 children with a mean age of 11.4 years. During a median follow-up period of 47.5 months, 58 patients (14.0%) reached the primary outcome. The two prediction models from the International IgA Nephropathy Prediction Tool exhibited suboptimal prediction power, with an integrated area under the curve (AUC) level of 0.57 (model with race) and 0.55 (model without race), respectively. The updated model, incorporating additional coefficients (sex, body mass index, serum albumin, presenting symptoms), showed good agreement between predicted risk and observed outcomes for Korean children (integrated AUC level of 0.70), significantly better than the IgAN International tool. Various model performance assessments showed consistent results. External validation with 145 children also demonstrated a superior fit for our model. CONCLUSION: The updated International IgA Nephropathy Prediction Tool for children had suboptimal prediction ability in Korean IgAN children whereas our proposed model showed acceptable prediction ability in this population. FAU - Park, Peong Gang AU - Park PG AD - Department of Pediatrics, Ajou University School of Medicine, Suwon, Republic of Korea. AD - Department of Translational Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. FAU - Kim, Jayoun AU - Kim J AD - Medical Research Collaborating Center, Seoul National University Hospital, Seoul, Republic of Korea. FAU - Kim, Ji Hyun AU - Kim JH AD - Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. FAU - Ahn, Yo Han AU - Ahn YH AD - Departmecnt of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea. AD - Kidney Research Institute, Seoul National University Medical Research Center, Seoul, Republic of Korea. FAU - Kang, Hee Gyung AU - Kang HG AD - Departmecnt of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea. AD - Kidney Research Institute, Seoul National University Medical Research Center, Seoul, Republic of Korea. FAU - Suh, Jin-Soon AU - Suh JS AD - Department of Pediatrics, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. LA - eng PT - Journal Article DEP - 20250521 PL - Korea (South) TA - Kidney Res Clin Pract JT - Kidney research and clinical practice JID - 101586778 OTO - NOTNLM OT - Disease progression OT - IgA nephropathy OT - Pediatrics OT - Validation study EDAT- 2025/05/30 07:59 MHDA- 2025/05/30 07:59 CRDT- 2025/05/30 03:54 PHST- 2024/10/30 00:00 [received] PHST- 2025/02/10 00:00 [accepted] PHST- 2025/05/30 07:59 [medline] PHST- 2025/05/30 07:59 [pubmed] PHST- 2025/05/30 03:54 [entrez] AID - j.krcp.24.262 [pii] AID - 10.23876/j.krcp.24.262 [doi] PST - aheadofprint SO - Kidney Res Clin Pract. 2025 May 21. doi: 10.23876/j.krcp.24.262. PMID- 40443193 OWN - NLM STAT- MEDLINE DCOM- 20250710 LR - 20260813 IS - 1941-2452 (Electronic) IS - 0884-5336 (Print) IS - 0884-5336 (Linking) VI - 40 IP - 4 DP - 2025 Aug TI - Accuracy and reliability of bioelectrical impedance analysis for determining body composition among preterm infants. PG - 931-941 LID - 10.1002/ncp.11321 [doi] AB - BACKGROUND: Body composition is an important nutritional status indicator among preterm infants, but is challenging to measure in the neonatal intensive care unit (NICU). Bioelectrical impedance analysis (BIA) is highly feasible, but accuracy depends on using a valid prediction equation. We aimed to evaluate the accuracy of available prediction equations, relative to air displacement plethysmography (ADP) as the criterion method, within a cohort of hospitalized preterm infants. METHODS: Preterm infants (23-35 weeks' gestation) underwent concurrent BIA and ADP up to three times between birth and term equivalent age. Using 11 published prediction equations, we estimated infant body composition from BIA data. To determine validity, we used Bland-Altman plots to compare BIA-derived fat-free mass (FFM) with FFM measured concurrently by ADP. RESULTS: One hundred and fifteen infants, with a median 30 6/7 weeks' gestation, underwent 150 instances of concurrent BIA and ADP at ages 1 to 135 (median: 40) days. Agreement between BIA and ADP-derived FFM varied widely depending on the BIA equation used, with mean bias (+/-95% confidence limits) ranging from 0.14 (+/-0.24) to 1.34 (+/-1.51) kg. The Dung, Lingwood, and Tint equations demonstrated the greatest agreement with ADP, with a mean bias of 0.14-0.32 kg and narrow limits of agreement (+/-0.23-0.28 kg). All equations demonstrated some bias. CONCLUSION: BIA is a feasible tool for measuring body composition among preterm infants. Existing published equations demonstrate reasonable agreement with ADP but require a correction factor to adjust for bias. A novel prediction equation specific to preterm infants might offer improved agreement and reduced bias. CI - (c) 2025 American Society for Parenteral and Enteral Nutrition. FAU - Bell, Katherine A AU - Bell KA AUID- ORCID: 0000-0002-4287-0667 AD - Department of Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. AD - Harvard Medical School, Boston, Massachusetts, USA. FAU - Wang, Wei AU - Wang W AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Departments of Medicine and Neurology, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts, USA. FAU - Nagel, Emily M AU - Nagel EM AUID- ORCID: 0000-0002-5792-009X AD - Department of Pediatrics, Division of Neonatology, University of Minnesota, Minneapolis, Minnesota, USA. FAU - Pepin, Hunter AU - Pepin H AD - Department of Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. FAU - Plummer, Erin AU - Plummer E AD - Children's Minnesota-Minneapolis and St. Paul Hospitals, Minneapolis, Minnesota, USA. FAU - Buckley, Lauren A AU - Buckley LA AD - Department of Pediatrics, Division of Neonatology, University of Minnesota, Minneapolis, Minnesota, USA. FAU - Ramel, Sara E AU - Ramel SE AD - Department of Pediatrics, Division of Neonatology, University of Minnesota, Minneapolis, Minnesota, USA. FAU - Belfort, Mandy B AU - Belfort MB AUID- ORCID: 0000-0001-8799-3313 AD - Department of Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. AD - Harvard Medical School, Boston, Massachusetts, USA. LA - eng GR - R01 HD111016/HD/NICHD NIH HHS/United States GR - R01HD111016 (Mandy B. Belfort and Sara E. Ramel)/This research was funded by NICHD/ GR - K23 HD104000/HD/NICHD NIH HHS/United States GR - R01HD09732 (Mandy B. Belfort)/HD/NICHD NIH HHS/United States GR - K23HD104000 (Katherine A. Bell)/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20250530 PL - United States TA - Nutr Clin Pract JT - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JID - 8606733 SB - IM MH - Humans MH - *Electric Impedance MH - *Body Composition MH - *Infant, Premature MH - Infant, Newborn MH - Female MH - Male MH - Reproducibility of Results MH - Plethysmography MH - Gestational Age MH - Intensive Care Units, Neonatal MH - Nutritional Status MH - Cohort Studies PMC - PMC13122183 MID - NIHMS2089987 OTO - NOTNLM OT - body composition OT - life cycle OT - neonates OT - nutrition OT - nutrition assessment OT - research and diseases COIS- CONFLICTS OF INTEREST: The authors declare no conflicts of interest. EDAT- 2025/05/30 07:47 MHDA- 2025/07/10 06:27 PMCR- 2026/04/28 CRDT- 2025/05/30 03:13 PHST- 2025/04/10 00:00 [revised] PHST- 2025/02/11 00:00 [received] PHST- 2025/04/27 00:00 [accepted] PHST- 2025/07/10 06:27 [medline] PHST- 2025/05/30 07:47 [pubmed] PHST- 2025/05/30 03:13 [entrez] PHST- 2026/04/28 00:00 [pmc-release] AID - 10.1002/ncp.11321 [doi] PST - ppublish SO - Nutr Clin Pract. 2025 Aug;40(4):931-941. doi: 10.1002/ncp.11321. Epub 2025 May 30. PMID- 40442630 OWN - NLM STAT- MEDLINE DCOM- 20250530 LR - 20250602 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 May 29 TI - The relative validity of the updated Menzies Remote Short-Item Dietary Assessment Tool (MRSDAT) for use with remote Aboriginal and Torres Strait Islander children and adults. PG - 1990 LID - 10.1186/s12889-025-23233-x [doi] LID - 1990 AB - BACKGROUND: This study aimed to determine the relative validity of dietary quality index scores estimated using the updated version of the Menzies Remote Short-item Dietary Assessment Tool (MRSDAT), a food frequency questionnaire developed for use with remote Indigenous communities in Australia. METHODS: This validation study compares scores derived from the updated MRSDAT with those derived from 24-h recalls. Participants from nine remote communities across three discrete regions of Australia (Central Australia, North Northern Territory and Cape York) participated in June-September 2021, or May-July 2022. Participants were Indigenous children aged six months to five years, pregnant and/or breastfeeding Indigenous women, and overweight adult Indigenous males and females. The agreement between methods was explored using Lin's concordance correlation coefficient (CCC), Bland-Altman plots, weighted Cohen's kappa, paired samples t-tests and Wilcoxon signed-rank tests. Primary comparisons were completed for the whole sample, and primary and secondary comparisons for only participants with >/= 2 x 24 h recalls. RESULTS: Ninety-nine participants were recruited. The MRSDAT estimated dietary quality index scores 0.31/100 points higher than 24-h recall estimates for participants with >/= 2 x 24-h recalls, and 0.18/100 points higher for all participants, with consistent results for adults and children (CCC = Rc 0.58, 95% CI 0.39, 0.72). CONCLUSIONS: Updates to the MRSDAT have resulted in dietary quality index scores highly comparable to those derived from 24-h recalls. The MRSDAT has the practical advantages of speed and convenience for research purposes, and the built-in instant dietary feedback feature has application to service delivery settings given the robust results demonstrated in this validation study. CI - (c) 2025. The Author(s). FAU - Tonkin, Emma AU - Tonkin E AD - Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, VIC, 3168, Australia. emma.tonkin@monash.edu. AD - School of Public Health, The University of Queensland, Herston, QLD, 4006, Australia. emma.tonkin@monash.edu. FAU - Chan, Ellie AU - Chan E AD - Central Australian Aboriginal Congress, Alice Springs, NT, 0870, Australia. FAU - Deen, Caroline AU - Deen C AD - Apunipima Cape York Health Council, Bungalow, QLD, 4870, Australia. FAU - Fredericks, Bronwyn AU - Fredericks B AD - Office of the Deputy Vice-Chancellor, The University of Queensland, Herston, QLD, 4006, Australia. AD - Australian Research Council Centre of Excellence for Indigenous Futures, The University of Queensland, St Lucia, QLD, 4072, Australia. FAU - Dhurrkay, Morag AU - Dhurrkay M AD - Department of Infectious Diseases, The Doherty Institute, University of Melbourne, 3000, and Victorian Infectious Diseases, Royal Melbourne Hospital, Melbourne, 3050, Australia. FAU - Dissayanake, Hasthi U AU - Dissayanake HU AD - Department of Infectious Diseases, The Doherty Institute, University of Melbourne, 3000, and Victorian Infectious Diseases, Royal Melbourne Hospital, Melbourne, 3050, Australia. FAU - Dhurrkay, J AU - Dhurrkay J AD - Department of Infectious Diseases, The Doherty Institute, University of Melbourne, 3000, and Victorian Infectious Diseases, Royal Melbourne Hospital, Melbourne, 3050, Australia. FAU - Gurruwiwi, George AU - Gurruwiwi G AD - Department of Infectious Diseases, The Doherty Institute, University of Melbourne, 3000, and Victorian Infectious Diseases, Royal Melbourne Hospital, Melbourne, 3050, Australia. FAU - Biggs, Beverley-Ann AU - Biggs BA AD - Department of Infectious Diseases, The Doherty Institute, University of Melbourne, 3000, and Victorian Infectious Diseases, Royal Melbourne Hospital, Melbourne, 3050, Australia. FAU - Brimblecombe, Julie AU - Brimblecombe J AD - Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, VIC, 3168, Australia. AD - School of Public Health, The University of Queensland, Herston, QLD, 4006, Australia. AD - Menzies School of Health Research, Casuarina, NT, 0810, Australia. LA - eng GR - 2017170/National Health and Medical Research Council/ PT - Journal Article PT - Validation Study DEP - 20250529 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Child, Preschool MH - Australia MH - Infant MH - Reproducibility of Results MH - *Nutrition Assessment MH - *Diet Surveys/methods MH - Australian Aboriginal and Torres Strait Islander Peoples MH - Surveys and Questionnaires/standards MH - *Diet MH - Young Adult MH - Pregnancy MH - Middle Aged PMC - PMC12121242 OTO - NOTNLM OT - Australia OT - Diet OT - Dietary assessment OT - First Nations OT - Food OT - Indigenous OT - Public health OT - Questionnaire COIS- Declarations. Ethics approval and consent to participate: The studies were approved by the Research Governance Committee of Apunipima Cape York Health Council, The Central Australian Aboriginal Congress Board, Miwatj Health, the East Arnhem Regional Council, Central Australian Human Research Ethics Committee (CA-20-3701), The University of Queensland Human Research Ethics Committee B (2020000636) and The Human Research Ethics Committee of The Northern Territory Health and Menzies School of Health Research (2021-4166). Written informed consent was provided by each participant, or their caregiver, after study procedures had been explained. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/05/30 02:07 MHDA- 2025/05/30 02:08 PMCR- 2025/05/29 CRDT- 2025/05/29 23:40 PHST- 2023/09/03 00:00 [received] PHST- 2025/05/19 00:00 [accepted] PHST- 2025/05/30 02:08 [medline] PHST- 2025/05/30 02:07 [pubmed] PHST- 2025/05/29 23:40 [entrez] PHST- 2025/05/29 00:00 [pmc-release] AID - 10.1186/s12889-025-23233-x [pii] AID - 23233 [pii] AID - 10.1186/s12889-025-23233-x [doi] PST - epublish SO - BMC Public Health. 2025 May 29;25(1):1990. doi: 10.1186/s12889-025-23233-x. PMID- 40441761 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251001 LR - 20251003 IS - 2713-4148 (Electronic) IS - 2713-4148 (Linking) VI - 68 IP - 10 DP - 2025 Oct TI - Adenosine deaminase and interleukin-1 receptor antagonist genetic polymorphisms among obese children with versus without metabolic dysfunction-associated fatty liver disease. PG - 808-818 LID - 10.3345/cep.2025.00731 [doi] AB - BACKGROUND: Metabolic disorder-associated fatty liver disease (MAFLD) in children is an emerging global health concern, particularly in terms of obesity and metabolic disturbances. Inflammation plays a crucial role in the pathogenesis of MAFLD, with adenosine deaminase (ADA) and interleukin-1 receptor antagonist (IL-1Ra) being potential contributors. PURPOSE: This study aimed to assess the association between ADA G22A and IL-1RN single nucleotide polymorphisms (SNPs) and MAFLD among a cohort of Egyptian children. It also aimed to evaluate the validity of very low-density lipoprotein (VLDL)/high-density lipoprotein cholesterol (HDL-C) and triglyceride-to-HDL-C ratios for predicting MAFLD in obese children. METHODS: One hundred obese children and 50 healthy controls were included. The obese group was further categorized into those with versus without MAFLD. IL-1Ra and ADA G22A SNPs were evaluated using conventional polymerase chain reaction (PCR) and restriction fragment length polymorphism-PCR, respectively. VLDL/HDL and triglyceride-to-HDL ratios were calculated from the lipid profiles of the included participants. RESULTS: The obese children had significantly higher weight, weight z score, body mass index (BMI), BMI z score, and waist circumference than the healthy controls. These parameters were considerably higher in children with versus without MAFLD P<0.05 all. The GG genotype and G allele of ADA G22A were significantly more frequent in the obese children versus controls (P<0.05 for both); however, no significant difference was observed between obese children with versus without MAFLD. Regarding IL-1RN polymorphisms, the *2/*2 genotype was more common in the controls and obese children without MFLD, whereas the *1/*2 genotype was prevalent in the obese children with MAFLD (P<0.05 all). A VLDL/HDL-C cutoff ratio of >0.6308 showed 80% sensitivity, 58% specificity, a 65.6% positive predictive value (PPV), a 74.4% negative predictive value, and 69% accuracy at differentiating among MAFLD cases. The triglyceride-to-HDL-C ratio cutoff of >3.0685 demonstrated high specificity (88%) and a high PPV (84.2%) but moderate sensitivity (64%) and overall accuracy (76%). CONCLUSION: The current study's findings support the possible genetic role of ADA G22A in childhood obesity, with a significant role for the IL-1RN SNP in the development of MAFLD in obese children. The triglyceride-to-HDL-C ratio was more useful than the VLDL/HDL-C ratio for predicting pediatric MAFLD. FAU - Sakhr, Hala M AU - Sakhr HM AD - Department of Pediatrics, Faculty of Medicine, South Valley University, Qena, Egypt. FAU - Hassan, Mohammed H AU - Hassan MH AD - Department of Medical Biochemistry, Faculty of Medicine, South Valley University, Qena, Egypt. FAU - Taha, Azza Mohamed AU - Taha AM AD - Department of Pediatrics, Faculty of Medicine, South Valley University, Qena, Egypt. FAU - Bakri, Ali Helmi AU - Bakri AH AD - Department of Pediatrics, Faculty of Medicine, South Valley University, Qena, Egypt. LA - eng PT - Journal Article DEP - 20250529 PL - Korea (South) TA - Clin Exp Pediatr JT - Clinical and experimental pediatrics JID - 101761234 PMC - PMC12488282 OTO - NOTNLM OT - Adenosine deaminase OT - Genetic polymorphism OT - HDL cholesterol OT - Interleukin 1 receptor antagonist protein OT - Metabolic dysfunction-associated fatty liver disease OT - Triglycerides OT - VLDL cholesterol COIS- Conflicts of interest No potential conflict of interest relevant to this article was reported. EDAT- 2025/05/30 01:57 MHDA- 2025/05/30 01:58 PMCR- 2025/05/29 CRDT- 2025/05/29 20:50 PHST- 2025/03/28 00:00 [received] PHST- 2025/05/08 00:00 [accepted] PHST- 2025/05/30 01:58 [medline] PHST- 2025/05/30 01:57 [pubmed] PHST- 2025/05/29 20:50 [entrez] PHST- 2025/05/29 00:00 [pmc-release] AID - cep.2025.00731 [pii] AID - cep-2025-00731 [pii] AID - 10.3345/cep.2025.00731 [doi] PST - ppublish SO - Clin Exp Pediatr. 2025 Oct;68(10):808-818. doi: 10.3345/cep.2025.00731. Epub 2025 May 29. PMID- 40441498 OWN - NLM STAT- MEDLINE DCOM- 20250811 LR - 20260920 IS - 1873-4847 (Electronic) IS - 0955-2863 (Linking) VI - 144 DP - 2025 Oct TI - Blood methylation signatures in childhood obesity and risk of cardiac hypertrophy in young adults: Findings from the BCAMS study and Mendelian randomization analysis. PG - 109979 LID - S0955-2863(25)00142-1 [pii] LID - 10.1016/j.jnutbio.2025.109979 [doi] AB - Childhood obesity may induce epigenetic changes, affecting long-term cardiac health. However, empirical evidence remains scarce. Leveraging the prospective cohort of Beijing Child and Adolescent Metabolic Syndrome study (BCAMS), we investigated the blood DNA methylation signatures associated with childhood obesity and the future risk of cardiac hypertrophy in young adults, confirming causality with Mendelian randomization (MR). The BCAMS study followed children into adulthood. Data including blood DNA methylation profiles, along with lifestyles, blood levels of 7 adipokines and 32 amino acids were collected at baseline. Echocardiographic measurements were assessed at the 10-year follow-up. Enrichment and correlation analyses were performed, and two-sample MR analyses involving 105,268 participants from European biobanks were employed to infer causality. Cross-sectionally, we identified 376 differentially methylated sites between children with obesity and normal-weight controls (n=25), particularly within genes enriched in the cardiomyopathy pathway. Longitudinally, 11 childhood obesity-associated methylation sites, especially cg25835058 (KAZN), cg01362389 (TDH) and cg12099423 (SLC17A9), showed strong correlations with left ventricular index (LVMI) at the 10-year follow-up (P<.0017). Additionally, these sites were associated with traditional risk factors, notably glutamine, which displayed strongest protective association with LVMI (-1.72g/m(2.7) per 1SD increase, P<.001) when validated with the entire cohort (n=326). MR analysis confirmed the significant correlation between cg12099423 methylation levels and SLC17A9 expression, and the causality between gene expression levels (KAZN, TDH, SLC17A9) and LVMI. Methylation associated with childhood obesity, particularly SLC17A9, may function as an epigenetic mechanism impacting long-term cardiac health later in life, emphasizing the significance of early intervention. CI - Copyright (c) 2025 Elsevier Inc. All rights reserved. FAU - Yi, Xinghao AU - Yi X AD - Department of Endocrinology, NHC Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. FAU - Zhu, Haoxue AU - Zhu H AD - Department of Endocrinology, NHC Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. FAU - Zhong, Ling AU - Zhong L AD - Department of Endocrinology, NHC Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. FAU - He, Mengyu AU - He M AD - Department of Endocrinology, NHC Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. FAU - Gao, Shan AU - Gao S AD - Department of Endocrinology, Xuan Wu Hospital, Capital Medical University, Beijing, China. Electronic address: gaoshanmw@163.com. FAU - Li, Ming AU - Li M AD - Department of Endocrinology, NHC Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. Electronic address: liming@pumch.cn. LA - eng SI - ClinicalTrials.gov/NCT03421444 PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250527 PL - United States TA - J Nutr Biochem JT - The Journal of nutritional biochemistry JID - 9010081 SB - IM MH - Humans MH - *DNA Methylation MH - Mendelian Randomization Analysis MH - *Pediatric Obesity/blood/genetics/complications MH - Male MH - Female MH - Child MH - Adolescent MH - *Cardiomegaly/genetics/blood/etiology MH - Young Adult MH - Prospective Studies MH - Cross-Sectional Studies MH - Epigenesis, Genetic MH - Adult MH - Risk Factors OTO - NOTNLM OT - Cardiac hypertrophy OT - Child cohort OT - DNA methylation OT - Mendelian randomization OT - Obesity COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/05/30 01:39 MHDA- 2025/08/12 00:27 CRDT- 2025/05/29 19:35 PHST- 2024/04/18 00:00 [received] PHST- 2025/03/08 00:00 [revised] PHST- 2025/05/25 00:00 [accepted] PHST- 2025/08/12 00:27 [medline] PHST- 2025/05/30 01:39 [pubmed] PHST- 2025/05/29 19:35 [entrez] AID - S0955-2863(25)00142-1 [pii] AID - 10.1016/j.jnutbio.2025.109979 [doi] PST - ppublish SO - J Nutr Biochem. 2025 Oct;144:109979. doi: 10.1016/j.jnutbio.2025.109979. Epub 2025 May 27. PMID- 40439945 OWN - NLM STAT- MEDLINE DCOM- 20250529 LR - 20261010 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 184 IP - 6 DP - 2025 May 29 TI - Hand grip strength trajectories and the risk of low bone mineral density in 6-7-year-old children: a prospective study. PG - 370 LID - 10.1007/s00431-025-06204-7 [doi] AB - Hand grip strength (HGS) is significantly correlated with bone mineral density (BMD), but has been assessed at a single time point in the cross-sectional study. The relationship between long-term patterns of HGS and BMD has neglected and not been proven. Therefore, this study aimed to explore the long-term HGS trajectories in 6-7 years old children and the risk of low BMD. This study included 1122 individuals with healthy BMD from Hebei Children and Adolescents aged 6-7 years Cohort Study in 2018 (baseline). HGS was measured 3 times repeatedly in 2018, 2020, and 2022. A cohort-based trajectory model was used to identify 4-year HGS developmental trajectories in the total participants, while HGS developmental trajectories were identified separately in subgroup analyses for sex, body mass index (BMI), and height. Cox proportional hazards models were used to test the association between HGS trajectories and low BMD. Three trajectories of HGS in the 1122 participants from 2018 to 2022 were identified and labeled as low-rate growth (blue-group1) (530, 47.2%), moderately-rate growth (red-group2) (518, 46.2%), and high-rate growth (green-group3) (74, 6.6%) respectively. Only 102 cases of low BMD were identified, the risk of low BMD was 9.1%. Participants in the low-rate growth group had a higher incidence of low BMD compared with the high-rate growth group [12.8% vs 2.7%, hazard ratio (HR): 5.74; 95% confidence interval (CI): 1.31, 25.15; P = 0.02]. Besides, the risk of low BMD decreased with the HGS changing trajectory increased in those two models (P(trend) < 0.05). And the same dose-response relationship was demonstrated in subgroup analyses of sex (boys, girls); however, in subgroup analyses for body mass index (normal, overweight/obese) and height ( median), this relationship was only observed in those with normal BMI and height > P(50). CONCLUSION: The HGS changing trajectories were associated with the risk of new-onset low BMD, and low BMD risk decreased with the HGS changing trajectory increase. Future studies with larger sample sizes are needed to validate the relationship between HGS and BMD. TRIAL REGISTRATION: Clinicaltrials.gov Identifier: ChiCTR2400083223; date registered: April 18, 2024. Registered under the name: "A bidirectional cohort study on the growth and development of children and adolescents in Hebei Province." WHAT IS KNOWN: * Cross-sectional study finds significant correlation between handgrip strength (HGS) and bone mineral density (BMD). * The relationship between long-term patterns of HGS and BMD has neglected and not been proven. WHAT IS NEW: * Utilizing a group-based trajectory model to identify different patterns of HGS trajectories. * Low-rate growth HGS trajectory patterns are associated with a high risk of low BMD. CI - (c) 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Zhang, Nuoyun AU - Zhang N AD - Department of Epidemiology, School of Public Health, North China University of Science and Technology, 21 Bohai Road, Tangshan, Hebei, 063210, China. FAU - Liang, Chen AU - Liang C AD - Department of Epidemiology, School of Public Health, North China University of Science and Technology, 21 Bohai Road, Tangshan, Hebei, 063210, China. FAU - Du, Wei AU - Du W AD - Department of Epidemiology, School of Public Health, North China University of Science and Technology, 21 Bohai Road, Tangshan, Hebei, 063210, China. FAU - Zou, Mingxia AU - Zou M AD - Department of Epidemiology, School of Public Health, North China University of Science and Technology, 21 Bohai Road, Tangshan, Hebei, 063210, China. FAU - Kang, Qin AU - Kang Q AD - Department of Epidemiology, School of Public Health, North China University of Science and Technology, 21 Bohai Road, Tangshan, Hebei, 063210, China. FAU - Xia, Yuhao AU - Xia Y AD - Department of Epidemiology, School of Public Health, North China University of Science and Technology, 21 Bohai Road, Tangshan, Hebei, 063210, China. FAU - Bao, Yajing AU - Bao Y AD - Department of Epidemiology, School of Public Health, North China University of Science and Technology, 21 Bohai Road, Tangshan, Hebei, 063210, China. FAU - Feng, Liu AU - Feng L AD - Department of Epidemiology, School of Public Health, North China University of Science and Technology, 21 Bohai Road, Tangshan, Hebei, 063210, China. FAU - Ma, Tiancheng AU - Ma T AD - Department of Epidemiology, School of Public Health, North China University of Science and Technology, 21 Bohai Road, Tangshan, Hebei, 063210, China. FAU - Li, Feiyue AU - Li F AD - Department of Epidemiology, School of Public Health, North China University of Science and Technology, 21 Bohai Road, Tangshan, Hebei, 063210, China. FAU - Fan, Hongmin AU - Fan H AD - Department of Epidemiology, School of Public Health, North China University of Science and Technology, 21 Bohai Road, Tangshan, Hebei, 063210, China. hongminfan1004@ncst.edu.cn. AD - Hebei Key Laboratory of Occupational Health and Safety for Coal Industry, Tangshan, Hebei, China. hongminfan1004@ncst.edu.cn. AD - Hebei Coordinated Innovation Centre of Occupational Health and Safety, Tangshan, Hebei, China. hongminfan1004@ncst.edu.cn. AD - Tangshan Key Laboratory of Clinical Epidemiology, Tangshan, Hebei, China. hongminfan1004@ncst.edu.cn. LA - eng GR - 20377718D/the key Research and Development Projects of Hebei Province/ GR - 20377718D/the key Research and Development Projects of Hebei Province/ GR - 20377718D/the key Research and Development Projects of Hebei Province/ GR - 20377718D/the key Research and Development Projects of Hebei Province/ GR - 20377718D/the key Research and Development Projects of Hebei Province/ GR - 20377718D/the key Research and Development Projects of Hebei Province/ GR - 20377718D/the key Research and Development Projects of Hebei Province/ GR - 20377718D/the key Research and Development Projects of Hebei Province/ GR - 20377718D/the key Research and Development Projects of Hebei Province/ GR - 20377718D/the key Research and Development Projects of Hebei Province/ GR - 20377718D/the key Research and Development Projects of Hebei Province/ GR - 2016YFC0900600/the National Key Research and Development Program of China/ GR - 2016YFC0900600/the National Key Research and Development Program of China/ GR - 2016YFC0900600/the National Key Research and Development Program of China/ GR - 2016YFC0900600/the National Key Research and Development Program of China/ GR - 2016YFC0900600/the National Key Research and Development Program of China/ GR - 2016YFC0900600/the National Key Research and Development Program of China/ GR - 2016YFC0900600/the National Key Research and Development Program of China/ GR - 2016YFC0900600/the National Key Research and Development Program of China/ GR - 2016YFC0900600/the National Key Research and Development Program of China/ GR - 2016YFC0900600/the National Key Research and Development Program of China/ GR - 2016YFC0900600/the National Key Research and Development Program of China/ PT - Journal Article DEP - 20250529 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Child MH - Female MH - Humans MH - Male MH - Body Mass Index MH - *Bone Density/physiology MH - Cross-Sectional Studies MH - *Hand Strength/physiology MH - Prospective Studies MH - Risk Factors OTO - NOTNLM OT - Bone mineral density OT - Children OT - Hand grip strength OT - Trajectory COIS- Declarations. Ethical approval: The present study was conducted using the principles of good the Helsinki Declaration. Ethical approval was granted by the Ethics Committee of North China University of Science and Technology (No.10060, No.2024066), and informed consent was signed by all the guardians of participants. Consent for publication: The authors affirm that human research participants provided informed consent for publication of the images in Figs. 1 and 2. Competing interests: The authors declare no competing interests. EDAT- 2025/05/29 13:01 MHDA- 2025/05/29 13:02 CRDT- 2025/05/29 11:14 PHST- 2025/03/10 00:00 [received] PHST- 2025/05/15 00:00 [accepted] PHST- 2025/05/10 00:00 [revised] PHST- 2025/05/29 13:02 [medline] PHST- 2025/05/29 13:01 [pubmed] PHST- 2025/05/29 11:14 [entrez] AID - 10.1007/s00431-025-06204-7 [pii] AID - 10.1007/s00431-025-06204-7 [doi] PST - epublish SO - Eur J Pediatr. 2025 May 29;184(6):370. doi: 10.1007/s00431-025-06204-7. PMID- 40439382 OWN - NLM STAT- MEDLINE DCOM- 20250529 LR - 20250729 IS - 2476-762X (Electronic) IS - 1513-7368 (Print) IS - 1513-7368 (Linking) VI - 26 IP - 5 DP - 2025 May 1 TI - Risk Factors Associated with Breast Cancer among Women in Iraq: A Case-Control Study. PG - 1701-1708 LID - 91683 [pii] LID - 10.31557/APJCP.2025.26.5.1701 [doi] AB - BACKGROUND: Breast cancer is the most common malignant among females in Al-Najf, Iraq, the aim of the study was to identify risk factors associated with breast cancer. METHODS: A hospital-based case-control study was conducted by enrolled 100 women with breast cancer and 200 non-malignant women selected randomly by using purposive sampling methods in the National Hospital for Cancer Therapy in AL-Najaf Province. Data was collected by questionnaire form through direct interview, which consisted of four parts (sociodemographic variables, clinical variables, reproductive variables, behavior and lifestyle variables). Questionnaire form was reviewed by a panel of experts from different specialists for checking validity, while reliability was checked by Cronbach's alpha, and the result was (0.8). Risk factors were estimated descriptively using percentages and odd ratios with their correlated 95% confidence interval (CI). The predictors of the occurrence of breast cancer were determined using logistic regression to estimate unadjusted association and adjusted association. RESULT: Breast cancer risk was found to be increased in women with age after 40 years and elderly especially >/=60 years (OR: 10.18, 95% CI: 4.1388,25.048), illiterate women (OR: 2.24, 95% CI: 1.06, 4.73), living in low economic status (OR: 2.87, 95% CI: 1.31,6.27), smoking (2.634, 95% CI: 1.021,6.792), women who bottle-feed their children (OR: 2.16, 95% CI: 1.01,4.61), eating backed and processed food (P: <0.001), overweight and obese women (OR: 1.875, 95% CI: 0.208, 16.88) and (OR: 4.062, 95%CI: 0.463, 35.64), previous abortion (OR: 1.08, 95% CI: 0.64,1.83), women who didn't perform routine self-examination (P: 0.05), women who didn't have information about it (P: 0.041), women who didn't visit health facilities for breast examination (P: <0.001). CONCLUSION: The majority of participants had at least one risk factor for Breast cancer and had low knowledge; consequently, emphasize the role of breast cancer early detection program in healthcare facilities, regular training of doctors and healthcare professionals who work in the program with respects of updates. Elevating women's awareness regarding Breast cancer risk factors, lifestyle modification, importance of early detection, self-examination, and regular visits to healthcare facilities for routine breast examinations through educational campaigns, sharing health messages by using social media and healthcare professionals, also by sharing educational materials like posters. Community campaigns for detecting women at high risk for Breast cancer to give them special attention according to their risk profile. Further high-quality research in genetic concern, environmental factors, and our daily diet. FAU - Hassan, Farah Mohammed AU - Hassan FM AD - Department of Health, Al-Najaf Directorate, Ministry of Health, Al-Najaf Province, Iraq. LA - eng PT - Journal Article DEP - 20250501 PL - Thailand TA - Asian Pac J Cancer Prev JT - Asian Pacific journal of cancer prevention : APJCP JID - 101130625 SB - IM MH - Humans MH - Female MH - *Breast Neoplasms/epidemiology/etiology MH - Case-Control Studies MH - Risk Factors MH - Iraq/epidemiology MH - Middle Aged MH - Adult MH - Life Style MH - Surveys and Questionnaires MH - Prognosis MH - Follow-Up Studies MH - Aged MH - Young Adult PMC - PMC12290183 OTO - NOTNLM OT - Al-Najaf OT - Iraq OT - breast cancer OT - risk factor COIS- None. EDAT- 2025/05/29 13:06 MHDA- 2025/05/29 13:07 PMCR- 2025/03/01 CRDT- 2025/05/29 08:53 PHST- 2024/11/09 00:00 [received] PHST- 2025/05/29 13:07 [medline] PHST- 2025/05/29 13:06 [pubmed] PHST- 2025/05/29 08:53 [entrez] PHST- 2025/03/01 00:00 [pmc-release] AID - 91683 [pii] AID - 10.31557/APJCP.2025.26.5.1701 [doi] PST - epublish SO - Asian Pac J Cancer Prev. 2025 May 1;26(5):1701-1708. doi: 10.31557/APJCP.2025.26.5.1701. PMID- 40439316 OWN - NLM STAT- MEDLINE DCOM- 20250731 LR - 20250804 IS - 1535-1815 (Electronic) IS - 0749-5161 (Linking) VI - 41 IP - 8 DP - 2025 Aug 1 TI - A Descriptive Analysis of the Reliability of the Broselow Tape for Use in the US Pediatric Trauma Population: A Trauma Quality Improvement Program Study. PG - 587-591 LID - 10.1097/PEC.0000000000003362 [doi] AB - OBJECTIVES: Length-based weight estimation tools are used for estimating a pediatric patient's weight when the actual body weight is not readily available. We sought to evaluate the proportion of children that were >20% outside of the estimated weight range using data from the Trauma Quality Improvement Program (TQIP) registry. METHODS: We completed a retrospective review using data from the TQIP registry from 2017 to 2022. We included patients below 15 years of age who had a documented height within the range of the Broselow tape. We excluded patients without documentation of both height and weight and those that were >2x over the upper weight limit. We define underestimated as a patient's estimated weight being lower than their measured weight and overestimated as their estimated weight being higher than the measured weight. We particularly focused on under or overestimation by >20% as our primary outcome. RESULTS: A total of 204,097 patients met our inclusion criteria. Two percent of patient's weights were overestimated by >20%. Fourteen percent of patient's weights were underestimated by >20%. CONCLUSIONS: We found that nearly 1 in 7 patients' measured body weight was above the weight range estimated by the Broselow tape by >20%, creating the potential for medication underdosing. CI - Copyright (c) 2025 Written work prepared by employees of the Federal Government as part of their official duties is, under the U.S. Copyright Act, a "work of the United States Government" for which copyright protection under Title 17 of the United States Code is not available. As such, copyright does not extend to the contributions of employees of the Federal Government. FAU - McCullough, Ian S AU - McCullough IS AD - Department of Military and Emergency Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD. FAU - Givens, Melissa L AU - Givens ML AD - Department of Military and Emergency Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD. FAU - Welter, Kelli J AU - Welter KJ AD - Children's Hospital Colorado, Aurora, CO. FAU - Gale, Hannah L AU - Gale HL AD - Department of Pediatrics, Brooke Army Medical Center, JBSA Fort Sam Houston, TX. FAU - Sam, Ashley E AU - Sam AE AD - Department of Pediatrics, Saint Louis Children's Hospital, Washington University in Saint Louis School of Medicine, St Louis, MO. FAU - Henderson, Jonathan AU - Henderson J AD - Department of Emergency Medicine, Brooke Army Medical Center, JBSA Fort Sam Houston, TX. FAU - April, Michael D AU - April MD AD - Department of Military and Emergency Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD. FAU - Schauer, Steven G AU - Schauer SG AD - Department of Military and Emergency Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD. AD - Departments of Anesthesiology and Emergency Medicine, University of Colorado School of Medicine. AD - Center for Combat and Battlefield (COMBAT) Research, University of Colorado School of Medicine, Aurora, CO. LA - eng PT - Journal Article DEP - 20250529 PL - United States TA - Pediatr Emerg Care JT - Pediatric emergency care JID - 8507560 SB - IM MH - Humans MH - Retrospective Studies MH - *Quality Improvement MH - Child MH - Male MH - Female MH - Adolescent MH - *Body Weight MH - United States MH - Child, Preschool MH - Reproducibility of Results MH - Infant MH - Registries MH - *Wounds and Injuries MH - Body Height OTO - NOTNLM OT - Broselow OT - children OT - injury OT - pediatrics OT - tape OT - trauma OT - weight COIS- Disclosure: M.D.A. and S.G.S. have received funding from the Department of Defense in the form of grants to their institution. The remaining authors declare no conflict of interest. EDAT- 2025/05/29 13:01 MHDA- 2025/07/31 12:33 CRDT- 2025/05/29 08:33 PHST- 2024/08/06 00:00 [received] PHST- 2025/01/31 00:00 [accepted] PHST- 2025/07/31 12:33 [medline] PHST- 2025/05/29 13:01 [pubmed] PHST- 2025/05/29 08:33 [entrez] AID - 00006565-202508000-00001 [pii] AID - 10.1097/PEC.0000000000003362 [doi] PST - ppublish SO - Pediatr Emerg Care. 2025 Aug 1;41(8):587-591. doi: 10.1097/PEC.0000000000003362. Epub 2025 May 29. PMID- 40439092 OWN - NLM STAT- MEDLINE DCOM- 20250821 LR - 20260910 IS - 1532-4303 (Electronic) IS - 0277-0903 (Linking) VI - 62 IP - 9 DP - 2025 Sep TI - Association of the 2020 Healthy Eating Index with asthma in children and adolescents in the United States: a cross-sectional study of NHANES. PG - 1483-1492 LID - 10.1080/02770903.2025.2512596 [doi] AB - OBJECTIVE: Our goal was to investigate the connection between asthma and HEI-2020. DATA SOURCES: A cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2020. STUDY SELECTIONS: Diet quality was measured as HEI-2020 scores using 24-h and 2-day dietary recall data. A range of statistical methods, including as sensitivity analysis, restricted triple spline analysis, subgroup analysis, and multivariate logistic regression, were used to assess the relationship between the HEI-2020 and asthma. RESULTS: 2,740 (17.5%) of the 15,667 said a doctor or other health care provider had diagnosed them with asthma. The lower a child or adolescent's risk of developing asthma, after adjusting for pertinent factors, the higher the overall HEI-2020 score. The adjusted odds ratios (OR) for asthma in the second (Tertiles 2, 42.92-<51.9) and third (Tertiles 3, 42.92-51.9) groups were 0.93 (0.84-1.03) and 0.83 (0.73-0.94), respectively, in comparison to the group with the lowest HEI-2020 values (Tertiles 1, 18.35-<42.92). The results' resilience was further validated using stratified and sensitivity analyses. Asthma risk may also be decreased by eating less sodium and added sweets and more total fruits, whole fruits, seafood and plant proteins. CONCLUSION: There is a negative correlation between asthma and the Healthy Eating Index-2020 in children and adolescents in the United States. FAU - Lu, Tong AU - Lu T AD - Liaocheng Maternal and Child Health Hospital, Liaocheng, China. FAU - Yu, Qiang AU - Yu Q AD - Dalian Jin Pu New District Maternal and Child Health Care Hospital, Dalian, China. FAU - Che, Liyong AU - Che L AD - Dalian Jin Pu New District Maternal and Child Health Care Hospital, Dalian, China. FAU - Zhang, Xiaolan AU - Zhang X AD - The Third People's Hospital of Liaocheng City, Liaocheng, China. FAU - Che, Chao AU - Che C AD - Qilu Hospital of Shandong University, Jinan, China. FAU - Du, Linjun AU - Du L AD - The Third People's Hospital of Liaocheng City, Liaocheng, China. FAU - Jia, Jia AU - Jia J AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China. LA - eng PT - Journal Article PT - Review DEP - 20250605 PL - England TA - J Asthma JT - The Journal of asthma : official journal of the Association for the Care of Asthma JID - 8106454 SB - IM MH - Humans MH - *Asthma/epidemiology MH - Adolescent MH - Child MH - Cross-Sectional Studies MH - United States/epidemiology MH - Female MH - Nutrition Surveys MH - Male MH - *Diet, Healthy/statistics & numerical data MH - Child, Preschool MH - Risk Factors OTO - NOTNLM OT - Asthma OT - Children and adolescents in the United States OT - Healthy Eating Index-2020 OT - cross-sectional study EDAT- 2025/05/29 12:54 MHDA- 2025/08/31 19:59 CRDT- 2025/05/29 06:43 PHST- 2025/08/31 19:59 [medline] PHST- 2025/05/29 12:54 [pubmed] PHST- 2025/05/29 06:43 [entrez] AID - 10.1080/02770903.2025.2512596 [doi] PST - ppublish SO - J Asthma. 2025 Sep;62(9):1483-1492. doi: 10.1080/02770903.2025.2512596. Epub 2025 Jun 5. PMID- 40438754 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250531 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 16 DP - 2025 TI - The impact of parental psychological control on adolescents' physical activity: the mediating role of self-control and the moderating role of psychological capital. PG - 1501720 LID - 10.3389/fpsyg.2025.1501720 [doi] LID - 1501720 AB - OBJECTIVE: Insufficient physical activity poses a significant threat to adolescent health. Parental psychological control, as a typical negative parenting style, exerts profound influences on health-related behaviors among adolescents. This study aims to identify and elucidate the specific mechanisms through which parental psychological control impacts adolescent physical activity. Furthermore, it explores the roles of self-control ability and psychological capital in mediating the relationship between parenting styles and adolescent physical activity. The findings of this research seek to provide guidance for family education practices. METHODS: A survey was conducted on 1,010 students from the first year of junior high school to the second year of senior high school to assess parental psychological control, physical activity, self-control, and psychological capital. Data analysis and model validation were performed using SPSS 26 and AMOS 24. RESULTS: A significant negative correlation was found between parental psychological control and adolescents' physical activity levels. Self-control was observed to partially mediate this relationship, while psychological capital played a negative moderating role in the adverse impact of parental psychological control on adolescents' physical activity. CONCLUSION: Parental psychological control had a negative impact on the level of physical activity among adolescents. Enhancing adolescents' self-control and psychological capital could serve as potential strategies to mitigate this negative effect, encouraging adolescents to actively engage in physical activities. This paper provided a new theoretical perspective and practical basis for improving family education methods and promoting positive health-enhancing behaviors among adolescents. CI - Copyright (c) 2025 Song, Ge and Zhang. FAU - Song, Chao AU - Song C AD - College of Sports Science, Tianjin Normal University, Tianjin, China. FAU - Ge, Sha AU - Ge S AD - College of Sports Science, Tianjin Normal University, Tianjin, China. FAU - Zhang, Weipeng AU - Zhang W AD - College of Sports Science, Tianjin Normal University, Tianjin, China. LA - eng PT - Journal Article DEP - 20250514 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC12116588 OTO - NOTNLM OT - parental psychological control OT - parenting style OT - physical activity of adolescents OT - psychological capacity OT - self-control OT - structural equation modeling COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/05/29 06:27 MHDA- 2025/05/29 06:28 PMCR- 2025/05/14 CRDT- 2025/05/29 04:45 PHST- 2024/09/25 00:00 [received] PHST- 2025/04/21 00:00 [accepted] PHST- 2025/05/29 06:28 [medline] PHST- 2025/05/29 06:27 [pubmed] PHST- 2025/05/29 04:45 [entrez] PHST- 2025/05/14 00:00 [pmc-release] AID - 10.3389/fpsyg.2025.1501720 [doi] PST - epublish SO - Front Psychol. 2025 May 14;16:1501720. doi: 10.3389/fpsyg.2025.1501720. eCollection 2025. PMID- 40438092 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250531 IS - 2048-7177 (Print) IS - 2048-7177 (Electronic) IS - 2048-7177 (Linking) VI - 13 IP - 6 DP - 2025 Jun TI - Determining the Range for Appropriate Gestational Weight Gain Proportion for Singleton Pregnant Chinese Women. PG - e70289 LID - 10.1002/fsn3.70289 [doi] LID - e70289 AB - To examine the optimal proportion of gestational weight gain (GWG) for Chinese singleton women based on Chinese body mass index (BMI) categories. A retrospective cohort study with 16,977 singleton pregnant women was conducted. Among the included subjects, 2/3 of whom were randomly imported into the training set for calculating the optimal proportion of GWG ranges, and another third of the women were imported into the validation set to evaluate the GWG ranges calculated with different methods. The detection rate of adverse outcomes of pregnant women with appropriate weight gain proportion under the above three methods was evaluated by paired chi-square test, using the data of pregnant women in the validation database. According to the percentile method, the suitable proportion of GWG of pregnant women with underweight, normal weight, overweight, or obesity before pregnancy was 25.8%-37.8%, 20.3%-30.8%, 13.0%-23.1%, respectively. According to the Odds ratio method, the suitable proportion of GWG for pregnant women with different BMI categories was 24%-34%, 14%-18%, and 4%-14%, respectively. According to the combined risk curve method, the suitable proportion of GWG for pregnant women with different BMI categories was 27.9%-32.5%, 11.5%-16.8%, and -2.1%-5.5%, respectively. When the proportion of GWG ranges from 27.9%-32.5%, 11.5%-16.8%, and -2.1%-5.5% for different BMI categories, the pregnant women with appropriate weight gain proportions have the lowest detection rate of adverse maternal and infant outcomes. The GWG proportion serves as a valuable clinical indicator for enabling personalized weight management strategies and tailored nutritional guidance during pregnancy. The recommended proportion of GWG in this study for underweight, normal, overweight, and obese pregnant women was 27.9%-32.5%, 11.5%-16.8%, and -2.1%-5.5%, respectively. CI - (c) 2025 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC. FAU - Jia, Yin AU - Jia Y AUID- ORCID: 0000-0002-7511-3689 AD - School of General Practice and Continuing Education Capital Medical University Beijing China. FAU - Jiang, Haili AU - Jiang H AD - Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital Capital Medical University, Beijing Maternal and Child Health Care Hospital Beijing China. FAU - Yu, Yang AU - Yu Y AD - School of Public Health Capital Medical University Beijing China. FAU - Fu, Yuhui AU - Fu Y AD - Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital Capital Medical University, Beijing Maternal and Child Health Care Hospital Beijing China. FAU - Li, Yue AU - Li Y AD - Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital Capital Medical University, Beijing Maternal and Child Health Care Hospital Beijing China. FAU - Wang, Huili AU - Wang H AD - School of General Practice and Continuing Education Capital Medical University Beijing China. LA - eng PT - Journal Article DEP - 20250527 PL - United States TA - Food Sci Nutr JT - Food science & nutrition JID - 101605473 PMC - PMC12117189 OTO - NOTNLM OT - adverse pregnancy outcomes OT - body mass index OT - gestational weight gain COIS- The authors declare no conflicts of interest. EDAT- 2025/05/29 06:26 MHDA- 2025/05/29 06:27 PMCR- 2025/05/27 CRDT- 2025/05/29 04:34 PHST- 2025/01/14 00:00 [received] PHST- 2025/04/29 00:00 [revised] PHST- 2025/05/05 00:00 [accepted] PHST- 2025/05/29 06:27 [medline] PHST- 2025/05/29 06:26 [pubmed] PHST- 2025/05/29 04:34 [entrez] PHST- 2025/05/27 00:00 [pmc-release] AID - FSN370289 [pii] AID - 10.1002/fsn3.70289 [doi] PST - epublish SO - Food Sci Nutr. 2025 May 27;13(6):e70289. doi: 10.1002/fsn3.70289. eCollection 2025 Jun. PMID- 40436026 OWN - NLM STAT- MEDLINE DCOM- 20250605 LR - 20250605 IS - 1465-3478 (Electronic) IS - 0963-7486 (Linking) VI - 76 IP - 4 DP - 2025 Jun TI - The role of Mediterranean diet in reducing household food waste: the UniFoodWaste study among italian students. PG - 443-455 LID - 10.1080/09637486.2025.2495719 [doi] AB - This is a cross-sectional study exploring the association between Mediterranean Diet (MD) adherence and food waste behaviours. A total of 2,697 Italian university students participated (28% high MD adherence). Participants with higher adherence to the MD exhibit food waste-conscious behaviours, measured using the validated Household Food Waste Behaviour (HFWB) questionnaire. Specifically, higher consumption of fruits, vegetables, and legumes was significantly associated with lower food waste scores. Greater adherence to the MD significantly reduced the odds of engaging in high-waste behaviours (OR = 0.50, 95%CI: 0.41-0.62, p < 0.001). Individuals with higher MD adherence demonstrated superior skills in managing leftovers and estimating food quantities. Parental influence on food waste behaviours was positively correlated with adherence to the MD. These findings highlight the potential of promoting the MD not only for its health benefits but also as a strategy for reducing household food waste, with implications for both public health and environmental sustainability. FAU - Nucci, Daniele AU - Nucci D AUID- ORCID: 0000-0003-4546-213X AD - Struttura Semplice Dipartimentale Igiene Alimenti e Nutrizione, Dipartimento di Igiene e Prevenzione Sanitaria, Agenzia di Tutela della Salute (ATS) Brescia, Brescia, Italy. AD - National PhD Programme in One Health approaches to infectious diseases and life science research, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy. FAU - Stacchini, Lorenzo AU - Stacchini L AUID- ORCID: 0000-0002-7405-4904 AD - Department of Community Healthcare Network, Health District "Toscana ASL Nord Ovest", Pontedera, Italy. AD - Medical School of Specialization in Hygiene and Preventive Medicine, University of Florence, Firenze, Italy. FAU - Villa, Maria AU - Villa M AD - Struttura Semplice Dipartimentale Igiene Alimenti e Nutrizione, Dipartimento di Igiene e Prevenzione Sanitaria, Agenzia di Tutela della Salute (ATS) Brescia, Brescia, Italy. FAU - Passeri, Chiara AU - Passeri C AD - Struttura Semplice Dipartimentale Igiene Alimenti e Nutrizione, Dipartimento di Igiene e Prevenzione Sanitaria, Agenzia di Tutela della Salute (ATS) Brescia, Brescia, Italy. FAU - Romano, Nicoletta AU - Romano N AD - Struttura Semplice Dipartimentale Igiene Alimenti e Nutrizione, Dipartimento di Igiene e Prevenzione Sanitaria, Agenzia di Tutela della Salute (ATS) Brescia, Brescia, Italy. FAU - Ferranti, Roberta AU - Ferranti R AD - Struttura Semplice Dipartimentale Igiene Alimenti e Nutrizione, Dipartimento di Igiene e Prevenzione Sanitaria, Agenzia di Tutela della Salute (ATS) Brescia, Brescia, Italy. FAU - Morsella, Alisha AU - Morsella A AD - Interfaculty of Economics and Medicine & Surgery, Universita Cattolica del Sacro Cuore, Rome, Italy. FAU - Veronese, Nicola AU - Veronese N AUID- ORCID: 0000-0002-9328-289X AD - Saint Camillus International University of Health Sciences, Rome, Italy. FAU - Maggi, Stefania AU - Maggi S AUID- ORCID: 0000-0002-0453-8663 AD - Consiglio Nazionale delle Ricerche, Neuroscience Institute, Padova, Italy. FAU - Gianfredi, Vincenza AU - Gianfredi V AUID- ORCID: 0000-0003-3848-981X AD - Department of Biomedical Sciences for Health, University of Milan, Milan, Italy. LA - eng PT - Journal Article DEP - 20250528 PL - England TA - Int J Food Sci Nutr JT - International journal of food sciences and nutrition JID - 9432922 RN - 0 (Food Loss and Waste) SB - IM MH - Humans MH - *Diet, Mediterranean MH - Italy MH - Male MH - Cross-Sectional Studies MH - Female MH - *Students MH - Young Adult MH - Adult MH - Surveys and Questionnaires MH - Family Characteristics MH - Vegetables MH - Adolescent MH - Feeding Behavior MH - Fruit MH - Food Loss and Waste OTO - NOTNLM OT - Italy OT - Mediterranean diet OT - cross-sectional study OT - household food waste OT - students EDAT- 2025/05/29 00:27 MHDA- 2025/06/05 06:28 CRDT- 2025/05/28 18:52 PHST- 2025/06/05 06:28 [medline] PHST- 2025/05/29 00:27 [pubmed] PHST- 2025/05/28 18:52 [entrez] AID - 10.1080/09637486.2025.2495719 [doi] PST - ppublish SO - Int J Food Sci Nutr. 2025 Jun;76(4):443-455. doi: 10.1080/09637486.2025.2495719. Epub 2025 May 28. PMID- 40435389 OWN - NLM STAT- MEDLINE DCOM- 20250528 LR - 20250528 IS - 1365-2214 (Electronic) IS - 0305-1862 (Linking) VI - 51 IP - 4 DP - 2025 Jul TI - Development and Psychometric Testing of a Physical Activity Parenting Practices Questionnaire for Chinese Youth. PG - e70106 LID - 10.1111/cch.70106 [doi] AB - BACKGROUND: Ensuring consistency in both conceptualization and operationalization of physical activity parenting practices is vital for translating insights on parental influences into effective intervention. This study aimed to develop a psychometrically sound measure for comprehensively assessing Chinese parents' parenting practices regarding early adolescents' physical activity. METHODS: A total of 70 measurement items were developed from translating, adapting and revising the Physical Activity Parenting Practice (PAPP) item bank. Content validity was assessed via consultation with 10 experts and cognitive interviews with six 7th graders. The psychometric properties assessed included structural validity via exploratory factor analysis and confirmatory factor analysis, internal consistency, predictive validity against adolescent-reported physical activity levels and test-retest reliability of construct scores over 2 weeks. The sample comprised 725 adolescents aged 12-15 years, of whom 114 completed the survey twice, 2 weeks apart. RESULTS: Eight PAPP constructs from the control, structure and autonomy support domains were identified forming a set of 49 measurement items. The structure within each domain demonstrated good model fit and comparable alignment with the international conceptual framework. The Cronbach's alpha coefficients of each construct ranged from 0.70 to 0.90. Five construct scores had significant positive associations with adolescents' physical activity levels (beta ranged from 0.14 to 0.43, p < 0.001). Test-retest construct scores generated moderate to large correlations with coefficients ranging from 0.60 to 0.80. CONCLUSION: Psychometric testing supported the reliability and validity of the physical activity parenting practice questionnaire for Chinese youth (CYPAPP). This culturally adapted measure would enable cross-cultural comparisons to better understand parental influences on adolescents' physical activity. CI - (c) 2025 John Wiley & Sons Ltd. FAU - Zhang, Youjie AU - Zhang Y AUID- ORCID: 0000-0003-4319-9809 AD - Department of Child Health and Social Medicine, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China. FAU - Cao, Ruohong AU - Cao R AD - Department of Child Health and Social Medicine, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China. FAU - Ma, Yana AU - Ma Y AD - Department of Child Health and Social Medicine, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China. LA - eng GR - 82204068/National Natural Science Foundation of China/ PT - Journal Article PT - Validation Study PL - England TA - Child Care Health Dev JT - Child: care, health and development JID - 7602632 RN - Chinese people SB - IM MH - Humans MH - Psychometrics MH - Adolescent MH - Female MH - Male MH - *Parenting/psychology/ethnology MH - Reproducibility of Results MH - Child MH - *Exercise/psychology MH - Surveys and Questionnaires MH - China MH - Parent-Child Relations MH - Factor Analysis, Statistical MH - *Adolescent Behavior/psychology MH - Parents/psychology MH - East Asian People OTO - NOTNLM OT - adolescents OT - parenting practices OT - physical activity OT - reliability OT - validity EDAT- 2025/05/28 18:27 MHDA- 2025/05/28 18:28 CRDT- 2025/05/28 14:53 PHST- 2025/05/14 00:00 [revised] PHST- 2025/02/17 00:00 [received] PHST- 2025/05/21 00:00 [accepted] PHST- 2025/05/28 18:28 [medline] PHST- 2025/05/28 18:27 [pubmed] PHST- 2025/05/28 14:53 [entrez] AID - 10.1111/cch.70106 [doi] PST - ppublish SO - Child Care Health Dev. 2025 Jul;51(4):e70106. doi: 10.1111/cch.70106. PMID- 40435038 OWN - NLM STAT- MEDLINE DCOM- 20250528 LR - 20250531 IS - 2237-9622 (Electronic) IS - 1679-4974 (Print) IS - 1679-4974 (Linking) VI - 34 DP - 2025 TI - Application of the Food Guide for the Brazilian Population as a training instrument for intersectoral actions: perceptions of professionals in a Brazilian metropolis. PG - e20240397 LID - S2237-96222025000100233 [pii] LID - 10.1590/S2237-96222025v34e20240397.en [doi] LID - e20240397 AB - OBJECTIVE: To analyze perceptions arising from an educational intervention based on the Food Guide for the Brazilian Population, aimed at health, education and social services professionals who work with children. METHODS: This was a qualitative study conducted with nine professional training course participants, using semi-structured interviews. The interviews took place one year after the training, on an online platform, with average duration of 30 minutes. The interview was validated previously, including questions to explore perceptions about the training course, the applicability of the Food Guide and challenges faced. Thematic analysis was performed in stages: familiarization with the data, direct labeling, data extraction and organization into matrices, development of preliminary themes and review to define final themes. RESULTS: The interviews were conducted with nine female professionals. Based on analysis of the data, the following themes were defined: Training and professional enhancement; Reflections produced by the Guide; and Intersectoral integration and collaboration. CONCLUSIONS: The Food Guide for the Brazilian Population promoted reflections on challenges in implementing actions to prevent childhood obesity. FAU - Davies, Vanessa Fernandes AU - Davies VF AUID- ORCID: 0000-0003-4331-2891 AD - Universidade Estadual de Campinas, Nucleo de Estudos e Pesquisas em Alimentacao, Campinas, SP, Brazil. FAU - Azevedo, Luiza Navarro de AU - Azevedo LN AUID- ORCID: 0009-0008-5812-9516 AD - Universidade Estadual de Campinas, Nucleo de Estudos e Pesquisas em Alimentacao, Campinas, SP, Brazil. AD - Universidade de Sao Paulo, Faculdade de Saude Publica, Sao Paulo, SP, Brazil. FAU - Pinheiro, Roberta Camila de Lima AU - Pinheiro RCL AUID- ORCID: 0009-0005-4195-637X AD - Universidade Estadual de Campinas, Nucleo de Estudos e Pesquisas em Alimentacao, Campinas, SP, Brazil. FAU - Baraldi, Larissa Galastri AU - Baraldi LG AUID- ORCID: 0000-0002-6793-7899 AD - Universidade Estadual de Campinas, Nucleo de Estudos e Pesquisas em Alimentacao, Campinas, SP, Brazil. LA - eng LA - por PT - Journal Article DEP - 20250523 PL - Brazil TA - Epidemiol Serv Saude JT - Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil JID - 101248287 SB - IM MH - Brazil MH - Humans MH - Female MH - Interviews as Topic MH - Child MH - *Pediatric Obesity/prevention & control MH - *Nutrition Policy MH - *Health Personnel/education MH - *Social Work/education MH - Qualitative Research MH - Adult PMC - PMC12105843 COIS- Conflicts of interest: None declared. EDAT- 2025/05/28 18:28 MHDA- 2025/05/28 18:29 PMCR- 2025/05/23 CRDT- 2025/05/28 13:34 PHST- 2024/08/30 00:00 [received] PHST- 2024/11/20 00:00 [accepted] PHST- 2025/05/28 18:29 [medline] PHST- 2025/05/28 18:28 [pubmed] PHST- 2025/05/28 13:34 [entrez] PHST- 2025/05/23 00:00 [pmc-release] AID - S2237-96222025000100233 [pii] AID - 10.1590/S2237-96222025v34e20240397.en [doi] PST - epublish SO - Epidemiol Serv Saude. 2025 May 23;34:e20240397. doi: 10.1590/S2237-96222025v34e20240397.en. eCollection 2025. PMID- 40434850 OWN - NLM STAT- MEDLINE DCOM- 20251201 LR - 20260708 IS - 1528-1132 (Electronic) IS - 0009-921X (Print) IS - 0009-921X (Linking) VI - 483 IP - 12 DP - 2025 Dec 1 TI - Femoral Trochlear Dysplasia Is Common in Lower Limbs With Hartofilakidis C2 Hip Dysplasia. PG - 2257-2268 LID - 10.1097/CORR.0000000000003557 [doi] AB - BACKGROUND: Patients with developmental dysplasia of the hip (DDH) can also present with deformities of the patellofemoral joint, such as femoral trochlear dysplasia. Although previous studies have reported that trochlear dysplasia is clinically important in some patients with DDH, the association between DDH and trochlear dysplasia is still unclear. QUESTIONS/PURPOSES: (1) Is trochlear dysplasia more common among lower limbs with bilateral DDH, with unilateral DDH, or without DDH (specifically, in the contralateral limb of patients with unilateral DDH)? (2) Is having more severe DDH (as measured by Hartofilakidis classification, Crowe classification, or according to angular measurements) associated with higher odds of having trochlear dysplasia? METHODS: This was a single-center retrospective comparative study. Between November 2018 and February 2024, a total of 439 patients with DDH (of whom 56% [248 of 439] had bilateral DDH and the remainder had unilateral DDH) underwent THA in our center. Of those, we considered as potentially eligible patients who were between ages 18 and 50 years, with a history of DDH that did not undergo surgical treatment prior to the THA, and who had available demographic and radiographic data. We then excluded 31% of the patients because 62 of them had a history of hip or knee treatment, 8 had a history of trauma or infection in the hip or knee, 24 had severe knee osteoarthritis, 9 had a history of neuromuscular disease, and the data from 33 patients were incomplete, leaving 303 patients (of whom 50% [152 of 303] had bilateral DDH, while the remainder had unilateral DDH; 455 affected and 151 unaffected limbs, in total) for the analysis. From those, we formed three study groups: 33% (152) of limbs randomly selected from one of the limbs of each patient with bilateral DDH were assigned to the bilateral group, 33% (151) of limbs selected from the ipsilateral side of patients with unilateral DDH were assigned to the unilateral group, and 33% (151) of limbs selected from the contralateral limbs in patients with unilateral DDH were assigned to the contralateral group. There were no differences in demographics, such as sex, age, and BMI, between patients with bilateral DDH and unilateral DDH. All patients underwent CT as a standard component of the preoperative evaluation process for THA. To answer our first question about in which group trochlear dysplasia is more common, we measured anatomic parameters related to the patellofemoral joint by three-dimensional CT, diagnosed trochlear dysplasia using a sulcus angle of >/= 145 degrees or a femoral trochlear depth of 0.80). RESULTS: The proportion of knees with trochlear dysplasia was higher in both the bilateral and unilateral groups compared with the contralateral group (34% [52 of 152] versus 12% [18 of 151], OR 3.8 [95% confidence interval (CI) 2.1 to 7.0]; p < 0.001 and 31% [47 of 151] versus 12% [18 of 151], OR 3.3 [95% CI 1.8 to 6.1]; p < 0.001, respectively). The bilateral and unilateral groups had a larger sulcus angle (143 degrees +/- 7 degrees versus 140 degrees +/- 7 degrees , mean difference 4 degrees [95% CI 2 degrees to 5 degrees ]; p < 0.001 and 144 degrees +/- 9 degrees versus 140 degrees +/- 7 degrees , mean difference 5 degrees [95% CI 3 degrees to 6 degrees ]; p < 0.001, respectively) and a shallower femoral trochlear depth (5 +/- 1 mm versus 6 +/- 2 mm, mean difference -1 [95% CI -3 to -1]; p < 0.001 and 5 +/- 2 mm versus 6 +/- 2 mm, mean difference -1 [95% CI -2 to -1]; p < 0.001, respectively) compared with the contralateral group. When all limbs with DDH were grouped by Hartofilakidis classification, we found that the group of Hartofilakidis C2 hips had a higher odds of trochlear dysplasia (53% [29 of 55], C2 versus the others OR 2.8 [95% CI 1.6 to 5.2]; p = 0.008) and the highest proportion of severe trochlear dysplasia knees (that is, they had both a sulcus angle of >/= 145 degrees and a femoral trochlear depth of 70th percentile) on the EDI-3 scale for Eating Disorder Risk (EDI-EDRC), with a psychological profile comparable to RED patients. Female gender (OR = 0.133, p = 0.020) and longer disease duration (OR = 1.055, p = 0.036) were identified as significant risk factors for the development of EDs. Conclusions: Our findings suggest common psychological traits between patients with REDs and patients with IBDs at risk of developing EDs during adolescence, highlighting the need for early screening for EDs in patients with IBDs who present with specific socio-demographic and disease characteristics. FAU - Riva, Anna AU - Riva A AUID- ORCID: 0000-0002-2898-094X AD - Department of Child Neuropsychiatry, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy. AD - School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy. FAU - Arienti, Gabriele AU - Arienti G AUID- ORCID: 0009-0003-1608-2821 AD - Department of Child Neuropsychiatry, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy. FAU - Zuin, Giovanna AU - Zuin G AD - Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy. FAU - Spini, Laura AU - Spini L AD - Department of Child Neuropsychiatry, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy. AD - School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy. FAU - Sansotta, Naire AU - Sansotta N AUID- ORCID: 0000-0002-8799-7266 AD - Department of Paediatric Hepatology Gastroenterology and Transplantation, Papa Giovanni XXIII Hospital, 24127 Bergamo, Italy. FAU - Cavanna, Andrea Eugenio AU - Cavanna AE AUID- ORCID: 0000-0003-0925-1255 AD - School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy. AD - Department of Neuropsychiatry, National Centre for Mental Health, Birmingham and Solihull Mental Health NHS Foundation Trust, Birmingham B15 2FG, UK. AD - School of Medical Sciences, College of Medicine and Health, University of Birmingham, Birmingham B15 2TT, UK. AD - School of Life and Health Sciences, Aston Brain Centre, Aston University, Birmingham B4 7ET, UK. AD - Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London WC1N 3BG, UK. FAU - Nacinovich, Renata AU - Nacinovich R AUID- ORCID: 0000-0002-3832-2860 AD - Department of Child Neuropsychiatry, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy. AD - School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy. LA - eng PT - Journal Article DEP - 20250517 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Adolescent MH - Male MH - Case-Control Studies MH - *Inflammatory Bowel Diseases/psychology/complications/physiopathology MH - *Feeding and Eating Disorders/psychology MH - Anorexia Nervosa/psychology MH - *Brain-Gut Axis/physiology MH - Affective Symptoms/psychology MH - *Avoidant Restrictive Food Intake Disorder/psychology PMC - PMC12114306 OTO - NOTNLM OT - adolescents OT - gut-brain axis OT - inflammatory bowel diseases OT - psychological symptoms OT - restrictive eating disorders COIS- The authors declare no conflicts of interest. EDAT- 2025/05/28 06:28 MHDA- 2025/05/28 06:29 PMCR- 2025/05/17 CRDT- 2025/05/28 01:34 PHST- 2025/04/11 00:00 [received] PHST- 2025/05/09 00:00 [revised] PHST- 2025/05/15 00:00 [accepted] PHST- 2025/05/28 06:29 [medline] PHST- 2025/05/28 06:28 [pubmed] PHST- 2025/05/28 01:34 [entrez] PHST- 2025/05/17 00:00 [pmc-release] AID - nu17101706 [pii] AID - nutrients-17-01706 [pii] AID - 10.3390/nu17101706 [doi] PST - epublish SO - Nutrients. 2025 May 17;17(10):1706. doi: 10.3390/nu17101706. PMID- 40431444 OWN - NLM STAT- MEDLINE DCOM- 20250528 LR - 20250531 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 10 DP - 2025 May 17 TI - Development and Validation of Nutrition Literacy Questionnaire for Chinese Pre-School Children. LID - 10.3390/nu17101704 [doi] LID - 1704 AB - Background: This study aims to develop and validate the Nutrition Literacy Questionnaire for Chinese Pre-school Children (NLQ-PSC). Methods: The reliability of the questionnaire was determined by internal consistency, the construct validity was assessed by exploratory factor analysis (EFA) and confirmatory factor analysis (CFA), and the content validity was assessed by the Pearson correlation coefficient. In order to analyze the application of NLQ-PSC, we conducted a cross-sectional study among 790 pre-school children. Results: From the literature review and qualitative methods, NLQ-PSC was developed, including two dimensions of knowledge and four practice dimensions. The NLQ-PSC questionnaire had good reliability and validity. The average NLQ-PSC score of all participants was 64.1 +/- 11.0, and we found that older children, girls, and children who had well-educated parents presented higher nutrition literacy. Conclusions: NLQ-PSC has been validated and has shown good reliability and validity, and it could be considered a reliable tool to assess Chinese pre-school children. FAU - Wen, Jing AU - Wen J AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China. FAU - Zhang, Xiaoxuan AU - Zhang X AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China. FAU - Yin, Xueqian AU - Yin X AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China. FAU - Ma, Guansheng AU - Ma G AUID- ORCID: 0000-0001-8022-4597 AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China. FAU - Wang, Junbo AU - Wang J AUID- ORCID: 0000-0002-0719-5459 AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China. AD - Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Peking University, Beijing 100191, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20250517 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - Chinese people SB - IM MH - Child, Preschool MH - Female MH - Humans MH - Male MH - China MH - Cross-Sectional Studies MH - Factor Analysis, Statistical MH - Health Knowledge, Attitudes, Practice MH - *Health Literacy MH - Nutritional Status MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - East Asian People PMC - PMC12113865 OTO - NOTNLM OT - instrument assessment OT - nutrition literacy OT - nutrition literacy questionnaire OT - pre-school children COIS- The authors declare no conflicts of interest. EDAT- 2025/05/28 06:28 MHDA- 2025/05/28 06:29 PMCR- 2025/05/17 CRDT- 2025/05/28 01:34 PHST- 2025/04/15 00:00 [received] PHST- 2025/05/13 00:00 [revised] PHST- 2025/05/14 00:00 [accepted] PHST- 2025/05/28 06:29 [medline] PHST- 2025/05/28 06:28 [pubmed] PHST- 2025/05/28 01:34 [entrez] PHST- 2025/05/17 00:00 [pmc-release] AID - nu17101704 [pii] AID - nutrients-17-01704 [pii] AID - 10.3390/nu17101704 [doi] PST - epublish SO - Nutrients. 2025 May 17;17(10):1704. doi: 10.3390/nu17101704. PMID- 40431375 OWN - NLM STAT- MEDLINE DCOM- 20250528 LR - 20250531 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 10 DP - 2025 May 10 TI - Culinary Habits and Health: Analyzing the Impact of Cooking Practices and Knowledge Among Spanish Young Adults. LID - 10.3390/nu17101635 [doi] LID - 1635 AB - Background: Culinary habits and knowledge play a key role in shaping dietary behaviors and overall health. In Spain, societal changes have led to a decline in traditional Mediterranean practices and, in some cases, to unhealthy lifestyles. This study explores the relationship between culinary habits, knowledge, and health behaviors among adults in Spain. Methods: A cross-sectional study was conducted with 1534 participants using validated questionnaires to assess culinary habits, knowledge, and lifestyle factors. Data were collected online via snowball sampling and analyzed using the Kruskal-Wallis test and a Gaussian graphical model to explore variable associations. Results: Participants with healthy culinary habits reported higher self-perceived health and greater fruit and vegetable consumption, while those with unhealthy habits consumed more fast food. Higher culinary knowledge was linked to better dietary choices, more vegetables and cereals, and lower smoking rates. Higher home cooking frequency was moderately correlated with the use of healthy cooking techniques. The network analysis showed that the frequency of cooking at home is positively associated with gender and age. A similar association was found for time spent cooking. Positive associations were also found between living with the family and time spent cooking, while age showed a negative correlation with living situation. Centrality measures identified influential variables within the network. Conclusions: Culinary knowledge and habits strongly influence health behaviors. Network analysis underscores the importance of specific variables such as cooking frequency and living situation in shaping lifestyle patterns. Educational programs aimed at enhancing culinary skills could promote healthier eating behaviors and mitigate public health risks. FAU - Sandri, Elena AU - Sandri E AUID- ORCID: 0000-0001-5770-0719 AD - Faculty of Medicine and Health Sciences, Catholic University of Valencia San Vicente Martir, c/Quevedo, 2, 46001 Valencia, Spain. FAU - Capoferri, Michela AU - Capoferri M AD - Department of Animal Production and Health, Veterinary Public Health, and Food Science and Technology, Faculty of Veterinary Medicine, Institute of Biomedical Sciences, Cardenal Herrera-CEU University, Calle Santiago Ramon y Cajal 20, 46115 Alfara del Patriarca, Spain. FAU - Piredda, Michela AU - Piredda M AUID- ORCID: 0000-0001-5998-476X AD - Research Unit of Nursing Science, Department of Medicine and Surgery, Campus Bio-Medico di Roma University, Via Alvaro del Portillo, 21, 00128 Rome, Italy. FAU - Micheluzzi, Valentina AU - Micheluzzi V AD - Clinical and Interventional Cardiology, Sassari University Hospital, 07100 Sassari, Italy. AD - Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier, 1, 00133 Rome, Italy. LA - eng PT - Journal Article DEP - 20250510 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Female MH - *Cooking/methods MH - Spain MH - Cross-Sectional Studies MH - *Health Knowledge, Attitudes, Practice MH - Adult MH - Young Adult MH - *Feeding Behavior MH - *Health Behavior MH - Diet, Healthy MH - Life Style MH - Surveys and Questionnaires MH - Adolescent MH - Vegetables MH - Diet MH - Fruit PMC - PMC12113781 OTO - NOTNLM OT - diet OT - dietary patterns OT - eating behaviors OT - food and nutrition OT - food preferences OT - healthy habits COIS- The authors declare no conflicts of interest. EDAT- 2025/05/28 06:29 MHDA- 2025/05/28 06:30 PMCR- 2025/05/10 CRDT- 2025/05/28 01:34 PHST- 2025/04/13 00:00 [received] PHST- 2025/05/06 00:00 [revised] PHST- 2025/05/08 00:00 [accepted] PHST- 2025/05/28 06:30 [medline] PHST- 2025/05/28 06:29 [pubmed] PHST- 2025/05/28 01:34 [entrez] PHST- 2025/05/10 00:00 [pmc-release] AID - nu17101635 [pii] AID - nutrients-17-01635 [pii] AID - 10.3390/nu17101635 [doi] PST - epublish SO - Nutrients. 2025 May 10;17(10):1635. doi: 10.3390/nu17101635. PMID- 40427593 OWN - NLM STAT- MEDLINE DCOM- 20250528 LR - 20260330 IS - 2218-273X (Electronic) IS - 2218-273X (Linking) VI - 15 IP - 5 DP - 2025 May 11 TI - Melatonin Secretion and Impacts of Training and Match Schedules on Sleep Quality, Recovery, and Circadian Rhythms in Young Professional Football Players. LID - 10.3390/biom15050700 [doi] LID - 700 AB - Modern elite football is becoming increasingly physically demanding, often requiring training and matches to be played at night. This schedule may disrupt circadian rhythms and melatonin secretion, thereby impairing sleep and recovery. This study investigated the effects of training time on melatonin secretion, circadian phase markers, and sleep parameters in elite youth soccer players. Forty male players (aged 16-18 years) from an elite Spanish youth football club were studied. Two groups followed the same training program but trained either in the morning (MT) or in the evening (ET). Salivary melatonin was measured at six time points to determine the mean levels, dim light melatonin onset (DLMO), amplitude, and acrophase. Chronotype, sleep quality (PSQI), and daytime sleepiness (ESS) were assessed using validated questionnaires. Dietary intake and anthropometric variables were also recorded. The MT group had higher mean melatonin levels (p = 0.026) and earlier DLMO (p = 0.023) compared to the ET group. Sleep quality was significantly better in the MT group (p < 0.001), despite shorter sleep duration (p = 0.014). No major differences in diet or anthropometry were observed. The chronotype had a secondary effect on the circadian markers. Evening training is associated with alterations in melatonin rhythms and reduced sleep quality, possibly due to light-induced chronodisruption. These findings highlight the importance of training timing as a modifiable factor in the chronobiology and recovery of athletes. Incorporating circadian principles into training schedules may optimize resting time and thus performance and long-term health in athletes. FAU - Almendros-Ruiz, Antonio AU - Almendros-Ruiz A AUID- ORCID: 0009-0009-9023-118X AD - Health Science and Nutrition Research (HSNR-CTS1118), Department of Nutrition and Food Science, School of Pharmacy, University of Granada, 18071 Granada, Spain. AD - FSI Lab, Football Science Institute, 18016 Granada, Spain. FAU - Conde-Pipo, Javier AU - Conde-Pipo J AUID- ORCID: 0000-0003-0646-4044 AD - Health Science and Nutrition Research (HSNR-CTS1118), Department of Nutrition and Food Science, School of Pharmacy, University of Granada, 18071 Granada, Spain. AD - Department of Health Sciences, Faculty of Health Sciences, University of Jaen, 23071 Jaen, Spain. FAU - Aranda-Martinez, Paula AU - Aranda-Martinez P AUID- ORCID: 0000-0002-1171-010X AD - Centro de Investigacion Biomedica, Facultad de Medicina, Departamento de Fisiologia, Instituto de Biotecnologia, Parque Tecnologico de Ciencias de la Salud, Universidad de Granada, 18016 Granada, Spain. FAU - Olivares-Jabalera, Jesus AU - Olivares-Jabalera J AUID- ORCID: 0000-0003-4748-4578 AD - FSI Lab, Football Science Institute, 18016 Granada, Spain. FAU - Acuna-Castroviejo, Dario AU - Acuna-Castroviejo D AUID- ORCID: 0000-0002-9680-1560 AD - Centro de Investigacion Biomedica, Facultad de Medicina, Departamento de Fisiologia, Instituto de Biotecnologia, Parque Tecnologico de Ciencias de la Salud, Universidad de Granada, 18016 Granada, Spain. AD - Instituto de Investigacion Biosanitaria de Granada (ibs.GRANADA), 18016 Granada, Spain. FAU - Requena, Bernardo AU - Requena B AD - FSI Lab, Football Science Institute, 18016 Granada, Spain. FAU - Fernandez-Martinez, Jose AU - Fernandez-Martinez J AUID- ORCID: 0000-0002-5593-6733 AD - Centro de Investigacion Biomedica, Facultad de Medicina, Departamento de Fisiologia, Instituto de Biotecnologia, Parque Tecnologico de Ciencias de la Salud, Universidad de Granada, 18016 Granada, Spain. AD - Instituto de Investigacion Biosanitaria de Granada (ibs.GRANADA), 18016 Granada, Spain. FAU - Mariscal-Arcas, Miguel AU - Mariscal-Arcas M AUID- ORCID: 0000-0001-9852-4950 AD - Health Science and Nutrition Research (HSNR-CTS1118), Department of Nutrition and Food Science, School of Pharmacy, University of Granada, 18071 Granada, Spain. AD - FSI Lab, Football Science Institute, 18016 Granada, Spain. AD - Instituto de Investigacion Biosanitaria de Granada (ibs.GRANADA), 18016 Granada, Spain. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250511 PL - Switzerland TA - Biomolecules JT - Biomolecules JID - 101596414 RN - JL5DK93RCL (Melatonin) SB - IM MH - Humans MH - *Melatonin/metabolism MH - Male MH - *Circadian Rhythm/physiology MH - Adolescent MH - *Soccer/physiology MH - *Sleep Quality MH - Athletes MH - *Sleep/physiology MH - Saliva/metabolism PMC - PMC12109335 OTO - NOTNLM OT - circadian rhythm OT - football performance OT - melatonin OT - sleep OT - training time COIS- The authors declare no conflicts of interest. The funding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of the data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2025/05/28 06:28 MHDA- 2025/05/28 06:29 PMCR- 2025/05/11 CRDT- 2025/05/28 01:10 PHST- 2025/03/28 00:00 [received] PHST- 2025/05/07 00:00 [revised] PHST- 2025/05/08 00:00 [accepted] PHST- 2025/05/28 06:29 [medline] PHST- 2025/05/28 06:28 [pubmed] PHST- 2025/05/28 01:10 [entrez] PHST- 2025/05/11 00:00 [pmc-release] AID - biom15050700 [pii] AID - biomolecules-15-00700 [pii] AID - 10.3390/biom15050700 [doi] PST - epublish SO - Biomolecules. 2025 May 11;15(5):700. doi: 10.3390/biom15050700. PMID- 40427004 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250531 IS - 2227-9059 (Print) IS - 2227-9059 (Electronic) IS - 2227-9059 (Linking) VI - 13 IP - 5 DP - 2025 May 12 TI - Linking Dietary Patterns to Autism Severity and Developmental Outcomes: A Correlational Study Using Food Frequency Questionnaires; The Childhood Autism Rating Scale, Second Edition; And Developmental Profile 3. LID - 10.3390/biomedicines13051178 [doi] LID - 1178 AB - Background/Objectives: Autism Spectrum Disorder (ASD) is characterized by social communication challenges and repetitive behaviors. Children with ASD often exhibit selective eating habits that may result in nutritional deficiencies and exacerbate developmental issues. While food frequency questionnaires (FFQs) are effective for dietary assessment, the links between food preferences, ASD severity, and developmental outcomes remain underexplored, particularly in Bulgaria. This study examines these relationships using validated tools. Methods: The present report constitutes a pilot, hypothesis-generating substudy of the broader NutriLect project. This substudy involved 49 children aged 2-12 years diagnosed with ASD. Dietary patterns were evaluated with a modified FFQ, while ASD severity and developmental profiles were assessed using the Childhood Autism Rating Scale, Second Edition (CARS-2) and the Developmental Profile 3 (DP-3). Results: Among 49 ASD children (mean age = 6.89 +/- 2.15 years; 86% boys), 73.4% consumed grains/potatoes daily. Only 34.7% met combined fruit and vegetable recommendations. Only 36.7% met the recommendation for daily milk or other dairy product consumption. Fish was consumed at least twice weekly by only 22,4%. Furthermore, children with more severe autism were approximately 9.4 times more likely to consume grains daily (chi(2) = 14.319, p = 0.006). Logistic regression analyses indicated that higher cognitive scores were strongly associated with lower grain (OR approximately 0.044) and other dairy products consumption (OR approximately 0.337), yet with greater fish intake (OR approximately 3.317). In contrast, better communication skills corresponded to increased milk consumption (OR approximately 5.76), and higher physical development scores predicted more frequent egg consumption (OR approximately 4.40). Conclusions: The pronounced preference for grain and meat products, which are frequently ultra-processed, and avoidance of nutrient-dense foods in children with severe ASD symptoms underscore the need for tailored dietary interventions. These interventions must address sensory sensitivities, nutritional inadequacies, and the risks that selective nutrition can have on the nutritional status and development of the children. FAU - Marinov, Dimitar AU - Marinov D AUID- ORCID: 0000-0001-7092-2279 AD - Department of Hygiene and Epidemiology, Faculty of Public Health, Medical University of Varna, 55 Marin Drinov Str., 9000 Varna, Bulgaria. AD - Research Group Nutrilect, Department of Neuroscience, Research Institute, Medical University of Varna, 55 Marin Drinov Str., 9000 Varna, Bulgaria. FAU - Eyubova, Sevdzhihan AU - Eyubova S AUID- ORCID: 0000-0001-7386-6663 AD - Research Group Nutrilect, Department of Neuroscience, Research Institute, Medical University of Varna, 55 Marin Drinov Str., 9000 Varna, Bulgaria. AD - Department of Pedagogy and Management in Education, Faculty of Education, Konstantin Preslavsky University of Shumen, 115 Universitetska Str., 9700 Shumen, Bulgaria. FAU - Toneva, Albena AU - Toneva A AUID- ORCID: 0000-0002-8916-5703 AD - Department of Hygiene and Epidemiology, Faculty of Public Health, Medical University of Varna, 55 Marin Drinov Str., 9000 Varna, Bulgaria. AD - Research Group Nutrilect, Department of Neuroscience, Research Institute, Medical University of Varna, 55 Marin Drinov Str., 9000 Varna, Bulgaria. FAU - Chamova, Rositsa AU - Chamova R AUID- ORCID: 0000-0002-1782-8475 AD - Department of Hygiene and Epidemiology, Faculty of Public Health, Medical University of Varna, 55 Marin Drinov Str., 9000 Varna, Bulgaria. AD - Research Group Nutrilect, Department of Neuroscience, Research Institute, Medical University of Varna, 55 Marin Drinov Str., 9000 Varna, Bulgaria. FAU - Braykova, Rozalina AU - Braykova R AUID- ORCID: 0000-0003-4547-2725 AD - Department of Hygiene and Epidemiology, Faculty of Public Health, Medical University of Varna, 55 Marin Drinov Str., 9000 Varna, Bulgaria. AD - Research Group Nutrilect, Department of Neuroscience, Research Institute, Medical University of Varna, 55 Marin Drinov Str., 9000 Varna, Bulgaria. FAU - Hadzhieva, Stanislava AU - Hadzhieva S AD - Department of Hygiene and Epidemiology, Faculty of Public Health, Medical University of Varna, 55 Marin Drinov Str., 9000 Varna, Bulgaria. AD - Research Group Nutrilect, Department of Neuroscience, Research Institute, Medical University of Varna, 55 Marin Drinov Str., 9000 Varna, Bulgaria. FAU - Pancheva, Ruzha AU - Pancheva R AD - Department of Hygiene and Epidemiology, Faculty of Public Health, Medical University of Varna, 55 Marin Drinov Str., 9000 Varna, Bulgaria. AD - Research Group Nutrilect, Department of Neuroscience, Research Institute, Medical University of Varna, 55 Marin Drinov Str., 9000 Varna, Bulgaria. LA - eng GR - No. BG-RRP-2.004-0009-C02/European Union - Next Generation EU, through the National Recovery and Resilience Plan of the Republic of Bulgaria/ PT - Journal Article DEP - 20250512 PL - Switzerland TA - Biomedicines JT - Biomedicines JID - 101691304 PMC - PMC12108826 OTO - NOTNLM OT - ASD OT - autism OT - food frequency questionnaire (FFQ) OT - nutritional deficiencies OT - selective eating COIS- The authors declare no conflicts of interest. EDAT- 2025/05/28 06:29 MHDA- 2025/05/28 06:30 PMCR- 2025/05/12 CRDT- 2025/05/28 01:06 PHST- 2025/04/01 00:00 [received] PHST- 2025/04/29 00:00 [revised] PHST- 2025/05/06 00:00 [accepted] PHST- 2025/05/28 06:30 [medline] PHST- 2025/05/28 06:29 [pubmed] PHST- 2025/05/28 01:06 [entrez] PHST- 2025/05/12 00:00 [pmc-release] AID - biomedicines13051178 [pii] AID - biomedicines-13-01178 [pii] AID - 10.3390/biomedicines13051178 [doi] PST - epublish SO - Biomedicines. 2025 May 12;13(5):1178. doi: 10.3390/biomedicines13051178. PMID- 40426762 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250531 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 5 DP - 2025 Apr 30 TI - Construction and Validation of a PCA-Based Prediction Model for Preterm Infant Stunting Risk: A Retrospective Study. LID - 10.3390/children12050583 [doi] LID - 583 AB - OBJECTIVES: Developmental delay in preterm infants is a critical clinical issue, and early risk identification and prediction are essential. This study aims to develop and validate a predictive model for developmental delay, providing a scientific basis for clinical risk assessment and early intervention. METHODS: This study included preterm infants and their primary caregivers who were followed up at our center from May 2023 to September 2024. The samples were randomly divided into a training cohort, an internal validation cohort, and an external validation cohort. Independent risk factors for stunting were identified through univariate and multivariate logistic regression analyses, and predictive models and calibration were constructed accordingly. RESULTS: The five standardized indicators at 3, 6, 9, and 12 months for 507 preterm infants were analyzed using principal component analysis, and their developmental outcomes were grouped accordingly. Logistic regression analyses showed that gestational age, high-risk factors, knowledge of caregiving, caregiving experience, and the presence of other caregivers in the home were independent risk factors for the risk of preterm infants with stunted growth at 3, 6, 9, and 12 months. The nomogram showed the area under the receiver operating characteristic curve values of 0.743, 0.735, 0.752, and 0.774 in the training cohort; 0.855, 0.771, 0.870, and 0.786 in the internal validation cohort; 0.822, 0.804, 0.717, and 0.678 in the external validation cohort, respectively. The calibration curves, consistency index, and decision curve analysis all showed that the model was significantly better than a single indicator in predicting the risk of stunting in preterm infants. CONCLUSIONS: The stunting risk prediction model constructed in this study shows good predictive ability, which can help clinicians assess the risk of stunting in preterm infants and support the development of early intervention strategies. FAU - Dai, Kun AU - Dai K AD - School of Nursing, Wuhan University, Wuhan 430071, China. FAU - Yu, Rong AU - Yu R AD - Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Meng, Yushi AU - Meng Y AD - Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Yang, Xiaomeng AU - Yang X AD - School of Public Health, Wuhan University, Wuhan 430071, China. FAU - Jiang, Yixin AU - Jiang Y AD - School of Nursing, Wuhan University, Wuhan 430071, China. FAU - Luo, Jing AU - Luo J AD - School of Nursing, Wuhan University, Wuhan 430071, China. FAU - Fang, Kui AU - Fang K AD - The First Affiliated Hospital of China Medical University, Shenyang 110001, China. FAU - Wang, Suqing AU - Wang S AD - School of Nursing, Wuhan University, Wuhan 430071, China. FAU - Rong, Zhihui AU - Rong Z AD - Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. LA - eng PT - Journal Article DEP - 20250430 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12110705 OTO - NOTNLM OT - prediction model OT - preterm infants OT - principal component analysis OT - risk factors OT - stunting COIS- The authors declare that they have no competing interests. All authors have read and approved the final manuscript and consented to its publication. EDAT- 2025/05/28 06:28 MHDA- 2025/05/28 06:29 PMCR- 2025/04/30 CRDT- 2025/05/28 01:05 PHST- 2025/03/25 00:00 [received] PHST- 2025/04/20 00:00 [revised] PHST- 2025/04/25 00:00 [accepted] PHST- 2025/05/28 06:29 [medline] PHST- 2025/05/28 06:28 [pubmed] PHST- 2025/05/28 01:05 [entrez] PHST- 2025/04/30 00:00 [pmc-release] AID - children12050583 [pii] AID - children-12-00583 [pii] AID - 10.3390/children12050583 [doi] PST - epublish SO - Children (Basel). 2025 Apr 30;12(5):583. doi: 10.3390/children12050583. PMID- 40426760 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250531 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 5 DP - 2025 Apr 29 TI - Cardiorespiratory Fitness in Spanish Youth: The Roles of Sex, Age, Body Composition, and Healthy Lifestyle Habits in Cor-School Study. LID - 10.3390/children12050581 [doi] LID - 581 AB - Background/Objectives: Cardiorespiratory fitness (CRF) is a key indicator of current and future health in children and adolescents, and is influenced by both physiological and behavioral factors. This study examined the associations between CRF, body composition, and health-related habits in 685 children and adolescents (aged 8-16 years) who regularly participated in extracurricular sports programs in northeastern Spain. Methods: Participants underwent anthropometric assessments, completed a 20 m shuttle run test to evaluate CRF, and filled out validated questionnaires on physical activity levels, sleep quality, and adherence to the Mediterranean diet. Results: Significant sex differences were observed, with boys achieving higher CRF performance (p < 0.001), primarily associated with greater muscle mass (p < 0.001) and lower body fat percentage (p < 0.001). Age positively correlated with improved CRF (p < 0.001), whereas higher body mass index (p = 0.003) and fat mass (p = 0.020) negatively impacted fitness outcomes. Conclusions: These findings underscore the critical role of physical activity and optimal body composition in promoting cardiorespiratory fitness among youth, emphasizing the importance of targeted interventions to foster healthy behaviors from early childhood. Future research should adopt longitudinal designs to better elucidate the dynamic interactions between lifestyle factors, body composition, and physical fitness throughout childhood and adolescence. FAU - Aixa-Requena, Saul AU - Aixa-Requena S AUID- ORCID: 0009-0007-2034-4600 AD - Human Movement Research Group (RGHM), University of Lleida, Placa de Victor Siurana, 25003 Lleida, Spain. AD - Faculty of Education, Psychology and Social Work, Department of Specific Didactics, University of Lleida, 25003 Lleida, Spain. FAU - Pano-Rodriguez, Alvaro AU - Pano-Rodriguez A AUID- ORCID: 0000-0002-6816-6571 AD - Human Movement Research Group (RGHM), University of Lleida, Placa de Victor Siurana, 25003 Lleida, Spain. AD - Faculty of Education, Psychology and Social Work, Department of Specific Didactics, University of Lleida, 25003 Lleida, Spain. FAU - Hernandez-Gonzalez, Vicenc AU - Hernandez-Gonzalez V AUID- ORCID: 0000-0003-3201-3298 AD - Human Movement Research Group (RGHM), University of Lleida, Placa de Victor Siurana, 25003 Lleida, Spain. AD - Faculty of Education, Psychology and Social Work, Department of Specific Didactics, University of Lleida, 25003 Lleida, Spain. FAU - Conesa-Milian, Enric AU - Conesa-Milian E AUID- ORCID: 0009-0000-1435-1598 AD - Human Movement Research Group (RGHM), University of Lleida, Placa de Victor Siurana, 25003 Lleida, Spain. AD - Faculty of Education, Psychology and Social Work, Department of Specific Didactics, University of Lleida, 25003 Lleida, Spain. FAU - Batalla-Gavalda, Abraham AU - Batalla-Gavalda A AUID- ORCID: 0000-0003-4337-8890 AD - University School of Health and Sport (EUSES), Universitat Rovira i Virgili, 43870 Amposta, Spain. AD - Department of Education and Specific Didactics, Faculty of Humanities and Social Sciences, Universitat Jaume I, Castellon de la Plana, 12006 Castellon, Spain. FAU - Beltran-Garrido, Jose Vicente AU - Beltran-Garrido JV AUID- ORCID: 0000-0001-9286-8453 AD - Physical Exercise and Performance Research Group, Universidad Cardenal Herrera-CEU, CEU Universities, Castellon de la Plana, 12006 Castellon, Spain. AD - Department of Education Sciences, School of Humanities and Communication Sciences, Universidad Cardenal Herrera-CEU, CEU Universities, Castellon de la Plana, 12006 Castellon, Spain. FAU - Lopez-Laval, Isaac AU - Lopez-Laval I AUID- ORCID: 0000-0002-9304-3709 AD - Faculty of Health and Sport Science, Department of Physiatry and Nursing, University of Zaragoza, 50009 Huesca, Spain. FAU - Corbi, Francisco AU - Corbi F AUID- ORCID: 0000-0003-2630-6684 AD - National Institute of Sport and Physical Education (INEFC), University of Lleida, 25003 Lleida, Spain. FAU - Arnau-Salvador, Rosa AU - Arnau-Salvador R AD - Human Movement Research Group (RGHM), University of Lleida, Placa de Victor Siurana, 25003 Lleida, Spain. AD - Official College of Pharmacists of Castellon, 12004 Castellon, Spain. FAU - Reverter-Masia, Joaquin AU - Reverter-Masia J AUID- ORCID: 0000-0002-9441-2764 AD - Human Movement Research Group (RGHM), University of Lleida, Placa de Victor Siurana, 25003 Lleida, Spain. AD - Faculty of Education, Psychology and Social Work, Department of Specific Didactics, University of Lleida, 25003 Lleida, Spain. LA - eng GR - PID2020-117932RB-I00/State Program for Research, Development, and Innovation Oriented to the Challenges of Society, within the framework of the State Plan for R+D+I 2020-2024/ GR - 021 SGR 01619/Consolidated research group "Human Movement" of the Generalitat de Catalunya/ GR - 2024 FISDU 00122/predoctoral grants program FI SDUR from the Department of Research and Universities of the Generalitat de Catalunya, co-funded by the European Social Fund Plus/ GR - GIR 2024/32/CEU-UCH Research Group Support/ PT - Journal Article DEP - 20250429 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12109838 OTO - NOTNLM OT - body composition OT - cardiorespiratory fitness OT - gender differences OT - physical activity OT - youth health COIS- The authors declare no conflicts of interest. EDAT- 2025/05/28 06:28 MHDA- 2025/05/28 06:29 PMCR- 2025/04/29 CRDT- 2025/05/28 01:05 PHST- 2025/04/05 00:00 [received] PHST- 2025/04/26 00:00 [revised] PHST- 2025/04/28 00:00 [accepted] PHST- 2025/05/28 06:29 [medline] PHST- 2025/05/28 06:28 [pubmed] PHST- 2025/05/28 01:05 [entrez] PHST- 2025/04/29 00:00 [pmc-release] AID - children12050581 [pii] AID - children-12-00581 [pii] AID - 10.3390/children12050581 [doi] PST - epublish SO - Children (Basel). 2025 Apr 29;12(5):581. doi: 10.3390/children12050581. PMID- 40424191 OWN - NLM STAT- MEDLINE DCOM- 20250619 LR - 20260803 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 14 DP - 2025 Jun 19 TI - Technology Effects and Child Health: Wellness Impact and Social Effects (TECHWISE): Protocol for a Prospective, Observational, Real-World Study. PG - e69358 LID - 10.2196/69358 [doi] LID - e69358 AB - BACKGROUND: There has been controversy over the extent to which technology use in general-and social media exposure specifically-may be associated with adverse youth mental health outcomes. To date, studies have generally been small and exploratory, relying on youth self-reports to characterize technology and social media use patterns. The goal of this study is to explore the associations between objectively collected data, gathered through a commercially available app, and youth mental health outcomes. OBJECTIVE: The broad goal of this study is to characterize the association between objectively measured technology/social media use and a range of mental health-related outcomes. Three specific aims will be initially addressed. First, we aim to quantify the association between objectively measured smartphone use and measures of well-being. Second, we aim to differentiate types of engagement-specifically, the types of content consumed versus the overall time spent on the device-and examine their association with outcomes. Third, we aim to identify moderating factors, such as age, gender, and socioeconomic status, that might influence these relationships. A secondary broad objective of this research is to establish a freely available data resource that can be accessed by qualified investigators to address a much wider range of questions in the future. METHODS: Up to 1000 male, female, and nonbinary youth aged 8-17 years (inclusive), along with their primary caregivers, will be enrolled in the study. Youth participants must have their own dedicated iOS- or Android-based smartphone or tablet, and both they and their parents must be willing and able to download and install the data collection app on their devices. The study is open to all US-based participants who meet these 2 criteria. Following electronic consent (eConsent), participants and their caregivers will complete a range of baseline measures electronically, including assessments of psychiatric and social functioning, as well as measures of loneliness, digital stress, and disordered eating. Caregivers will be asked to provide information on the participant's health and mental health history. Youth and caregivers will then complete a similar battery of assessments 1, 2, and 3 months after baseline. Youth participants will also respond to daily questions about their mood, stress, physical activity, and sleep. Both youth and their caregivers will be compensated for completing measures at each time point. The data collection app gathers a wide range of daily data from the participant's device, including temporal patterns of use, the number and frequency of various app usage, social interactions within apps, and keystroke data. A variety of analytic methods will be used to address key questions related to how technology and social media use are associated with mental health and wellness outcomes. RESULTS: Enrollment for this study began on November 13, 2024. As of May 20, 2025, a total of 106 participants and their caregivers had consented to participate and provided baseline data. An additional 203 children and parents have consented and are currently undergoing eligibility verification and enrollment. Initial data analysis is anticipated to begin in late autumn 2025 or winter 2026, with the expected publication of initial findings in spring 2026. CONCLUSIONS: This study will be among the largest to date to collect both objective device usage data and validated, clinically relevant outcome measures. In accordance with our data-sharing policies, any qualified investigator will be able to access the study data, provided appropriate steps are followed. TRIAL REGISTRATION: ClinicalTrials.gov NCT06664944; https://clinicaltrials.gov/ct2/show/NCT06664944. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/69358. CI - (c)Scott H Kollins, Jessica Flannery, Karen Goetz, Samir Akre-Bhide. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 19.06.2025. FAU - Kollins, Scott H AU - Kollins SH AUID- ORCID: 0000-0001-6847-6935 AD - Aura Sub, LLC, Boston, NC, United States. FAU - Flannery, Jessica AU - Flannery J AUID- ORCID: 0000-0003-0710-2512 AD - Aura Sub, LLC, Boston, NC, United States. FAU - Goetz, Karen AU - Goetz K AUID- ORCID: 0009-0009-8223-2625 AD - Aura Sub, LLC, Boston, NC, United States. FAU - Akre-Bhide, Samir AU - Akre-Bhide S AUID- ORCID: 0000-0003-1495-6399 AD - Aura Sub, LLC, Boston, NC, United States. LA - eng SI - ClinicalTrials.gov/NCT06664944 PT - Journal Article DEP - 20250619 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - Child MH - Adolescent MH - Prospective Studies MH - Male MH - Female MH - *Child Health MH - *Social Media/statistics & numerical data MH - *Mental Health MH - Smartphone MH - Mobile Applications MH - Observational Studies as Topic PMC - PMC12226774 OTO - NOTNLM OT - adolescence OT - mental health OT - social media OT - technology use OT - youth COIS- Conflicts of Interest: SHK, JF, KG, and SAB are full-time employees of Aura and hold equity options. As the sponsor of this study, Aura employed all authors involved in the development of this protocol; no independent or unaffiliated researchers contributed. EDAT- 2025/05/27 18:28 MHDA- 2025/06/19 22:03 PMCR- 2025/06/19 CRDT- 2025/05/27 13:02 PHST- 2024/12/13 00:00 [received] PHST- 2025/05/23 00:00 [accepted] PHST- 2025/04/22 00:00 [revised] PHST- 2025/06/19 22:03 [medline] PHST- 2025/05/27 18:28 [pubmed] PHST- 2025/05/27 13:02 [entrez] PHST- 2025/06/19 00:00 [pmc-release] AID - v14i1e69358 [pii] AID - 10.2196/69358 [doi] PST - epublish SO - JMIR Res Protoc. 2025 Jun 19;14:e69358. doi: 10.2196/69358. PMID- 40423858 OWN - NLM STAT- MEDLINE DCOM- 20250627 LR - 20260702 IS - 0974-7559 (Electronic) IS - 0019-6061 (Linking) VI - 62 IP - 7 DP - 2025 Jul TI - Adherence of Children to the Indian Academy of Pediatrics (IAP) Guidelines on Permissible Daily Screen Exposure-A Hospital-Based Cross-Sectional Study from Southern India. PG - 528-530 LID - 10.1007/s13312-025-00097-3 [doi] AB - This study assessed the adherence to IAP guidelines on permissible daily screen exposure in 771 children aged 3 months to 14 years using a pre-validated questionnaire. The mean (SD) screen time (ST) was 2.62 (1.44) hours, with adherence rates of 1%, 8.8%, 3.2%, and 24.6% in children aged < 2 years, 2-5 years, 6-10 years, and 11-14 years, respectively. Factors like age, siblings, family size, school type, and home gadgets significantly influenced ST. Novel strategies and implementation techniques should be adopted to improve adherence among children. CI - (c) 2025. The Author(s), under exclusive licence to Indian Academy of Pediatrics. FAU - Veluguri, Siva Sai Sushumna AU - Veluguri SSS AD - Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Mangalagiri, Andhra Pradesh, India. FAU - Satapathy, Diptirekha AU - Satapathy D AUID- ORCID: 0000-0002-7869-6445 AD - Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Mangalagiri, Andhra Pradesh, India. FAU - Arun Babu, Thirunavukkarasu AU - Arun Babu T AUID- ORCID: 0000-0003-1123-5270 AD - Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Mangalagiri, Andhra Pradesh, India. babuarun@yahoo.com. FAU - Kalidoss, Vinothkumar AU - Kalidoss V AUID- ORCID: 0000-0002-1393-6209 AD - Department of Community and Family Medicine, All India Institute of Medical Sciences (AIIMS), Mangalagiri, Andhra Pradesh, 522503, India. LA - eng GR - STS 2023 (Reference ID: 2023-03153 )./Indian Council of Medical Research/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250527 PL - India TA - Indian Pediatr JT - Indian pediatrics JID - 2985062R SB - IM MH - Humans MH - Child MH - India MH - Child, Preschool MH - Cross-Sectional Studies MH - Adolescent MH - Male MH - Female MH - Infant MH - *Guideline Adherence/statistics & numerical data MH - *Screen Time MH - Surveys and Questionnaires MH - Pediatrics OTO - NOTNLM OT - Digital wellness OT - Mobile phone OT - Screen time OT - Smartphone Tablets OT - Video games COIS- Declarations. Conflict of interest: None. Consent to Participate: Written informed consent obtained from all parents to participate in the study. Consent for Publication: Written informed consent obtained from all parents to publish the study data. Ethical Approval: Procedures followed were in accordance with the Helsinki Declaration of 1964, as revised in 2013. The study was approved by the Institutional Ethics Committee Ref No: AIIMS/MG/IEC/2023-24/63 dated Dec 01, 2023. EDAT- 2025/05/27 12:45 MHDA- 2025/06/27 12:29 CRDT- 2025/05/27 11:17 PHST- 2024/11/01 00:00 [received] PHST- 2025/04/24 00:00 [accepted] PHST- 2025/06/27 12:29 [medline] PHST- 2025/05/27 12:45 [pubmed] PHST- 2025/05/27 11:17 [entrez] AID - 10.1007/s13312-025-00097-3 [pii] AID - 10.1007/s13312-025-00097-3 [doi] PST - ppublish SO - Indian Pediatr. 2025 Jul;62(7):528-530. doi: 10.1007/s13312-025-00097-3. Epub 2025 May 27. PMID- 40421430 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250530 IS - 2472-1972 (Electronic) IS - 2472-1972 (Linking) VI - 9 IP - 7 DP - 2025 Jul TI - Novel Pediatric Waist-to-height Ratio Fat Mass Cutoff Predicts Liver Steatosis and Fibrosis Better than Body Mass Index: The NHANES. PG - bvaf079 LID - 10.1210/jendso/bvaf079 [doi] LID - bvaf079 AB - BACKGROUND: Recent clinical consensus statements have emphasized a shift from diagnosing obesity with body mass index (BMI) requiring confirmation with surrogate markers such as waist circumference-to-height ratio (WHtR). WHtR is a highly sensitive and specific predictor of dual-energy X-ray absorptiometry-measured total body fat mass and abdominal fat mass but not lean mass. However, newly developed WHtR adiposity cut points warrant external validation before clinical application. OBJECTIVE: To examine whether new WHtR cut points predict liver steatosis and fibrosis in a multiracial population. METHODS: Data from 6464 (54% female) multiracial US participants from the National Health and Nutrition Examination Survey conducted between 2021 and 2023 were analyzed. Liver fibrosis was assessed with transient elastography and staged as fibrosis stage F0 to F4 and liver steatosis graded S0 to S3. RESULTS: Participants' mean (SD) age was 47.3 (20.9) years. The prevalence of WHtR cut points of 0.40 to <0.50 (normal fat mass), 0.5 to <0.53 (high fat mass), and >/=0.53 (excess fat mass) was 20.3%, 13.6%, and 64.5%. Multivariable-adjusted WHtR high fat mass predicted liver steatosis (odds ratio 1.63 [95% confidence interval 1.16-2.29] P = .005) and fibrosis (1.31 [1.01-1.70] P = .043). Excess WHtR fat mass was associated with liver steatosis (4.02 [2.87-5.64] P < .001) and fibrosis (1.61 [1.03-2.54] P = .038). Normal WHtR fat mass predicted lower odds of liver steatosis (0.52 [0.37-0.73] P < .001) and fibrosis/cirrhosis (0.48 [0.30-0.76] P < .001). WHtR high fat mass and excess fat mass separately predicted higher odds of liver steatosis 1.6-fold and 6-fold, respectively, better than BMI-overweight and BMI-obesity. CONCLUSION: The simple and universally accessible WHtR cut points may be useful in clinical and public health practice for obesity screening, diagnosis, and management. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of the Endocrine Society. FAU - Agbaje, Andrew O AU - Agbaje AO AUID- ORCID: 0000-0001-5138-3441 AD - Institute of Public Health and Clinical Nutrition, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland. AD - Children's Health and Exercise Research Centre, Department of Public Health and Sports Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter EX1 2LU, UK. LA - eng PT - Journal Article DEP - 20250503 PL - United States TA - J Endocr Soc JT - Journal of the Endocrine Society JID - 101697997 PMC - PMC12104973 OTO - NOTNLM OT - diagnosis OT - metabolism OT - obesity OT - overweight OT - pediatrics OT - prevention EDAT- 2025/05/27 06:27 MHDA- 2025/05/27 06:28 PMCR- 2025/05/03 CRDT- 2025/05/27 04:34 PHST- 2025/02/28 00:00 [received] PHST- 2025/05/27 06:28 [medline] PHST- 2025/05/27 06:27 [pubmed] PHST- 2025/05/27 04:34 [entrez] PHST- 2025/05/03 00:00 [pmc-release] AID - bvaf079 [pii] AID - 10.1210/jendso/bvaf079 [doi] PST - epublish SO - J Endocr Soc. 2025 May 3;9(7):bvaf079. doi: 10.1210/jendso/bvaf079. eCollection 2025 Jul. PMID- 40419977 OWN - NLM STAT- MEDLINE DCOM- 20250527 LR - 20260501 IS - 1471-2261 (Electronic) IS - 1471-2261 (Linking) VI - 25 IP - 1 DP - 2025 May 26 TI - Association between triglyceride glucose-waist to height ratio (TyG-WHtR) and hypertension in adults aged 18-60: a cross-sectional study. PG - 403 LID - 10.1186/s12872-025-04853-y [doi] LID - 403 AB - BACKGROUND: This study aimed to explore the association between TyG and the prevalence of hypertension in US adults aged 18-60. METHOD: Data was obtained from the National Health and Nutrition Examination Survey (NHANES) covering the circles from 2009 to 2018, involving 12,309 adults aged 18 to 60. The biomarkers studied in this article included weight, body mass index (BMI), waist circumference (WC), weight-adjusted waist index (WWI), waist-to-height ratio (WHtR), triglyceride-glucose index (TyG), triglyceride glucose-body mass index (TyG-BMI), triglyceride glucose-waist circumference (TyG-WC), triglyceride glucose-weight (TyG-Weight), and triglyceride glucose-waist to height ratio (TyG-WHtR). Participants were categorized into a non-Hypertension group (n = 7,076) and a Hypertension group (n = 5,233). A weighted multiple logistic regression model was employed to evaluate the association between biomarkers and hypertension. Restricted cubic splines (RCS) were utilized to examine the non-linear association between biomarkers and the risk of developing hypertension. Threshold effect analysis was used to determine the inflection point. Receiver operating characteristic (ROC) curves were generated to assess the predictive performance of biomarkers for hypertension. Additionally, subgroup and interaction analyses were conducted to confirm the reliability of the associations observed. RESULT: Our analysis revealed that after adjusting for multiple variables, the risk of hypertension increased by 12% for each unit increase in TyG-WHtR (P < 0.001). The RCS results showed a positive nonlinear association between TyG-WHtR and hypertension, with an inflection point of 5.79. Similar associations were also observed with WWI, WHtR, and TyG. The ROC curve analysis demonstrated that TyG-WHtR had the best predictive performance for hypertension (AUC: 0.6946, 95% CI: 0.6853-0.7039, Cut-off Value: 4.831, all P for comparison < 0.001). Subgroup analysis revealed that the association between TyG-WHtR and hypertension remains robust (all P for interaction > 0.05). CONCLUSION: There is a significant association between WWI, WHtR, TyG, and TyG-WHtR with hypertension in American adults aged 18 to 60, with TyG-WHtR demonstrating the best predicted performance. CLINICAL TRIAL NUMBER: Not applicable. CI - (c) 2025. The Author(s). FAU - Huang, Junwei AU - Huang J AD - Department of Cardiology, The First Hospital of Putian City, Putian, Fujian Province, China. FAU - Chen, Jinzao AU - Chen J AD - Department of Cardiology, The First Hospital of Putian City, Putian, Fujian Province, China. FAU - Pan, Guoyan AU - Pan G AD - Department of Cardiology, The First Hospital of Putian City, Putian, Fujian Province, China. FAU - Zheng, Liping AU - Zheng L AD - Department of Cardiology, The First Hospital of Putian City, Putian, Fujian Province, China. FAU - Weng, Jinri AU - Weng J AD - Department of Cardiology, The First Hospital of Putian City, Putian, Fujian Province, China. FAU - Weng, Chunfa AU - Weng C AD - Department of Cardiology, The First Hospital of Putian City, Putian, Fujian Province, China. FAU - Chen, Jianbin AU - Chen J AD - Department of Cardiology, The First Hospital of Putian City, Putian, Fujian Province, China. FAU - Lin, Bin AU - Lin B AD - Department of Cardiology, The First Hospital of Putian City, Putian, Fujian Province, China. FAU - Wu, Zhiwei AU - Wu Z AD - Department of Cardiology, The First Hospital of Putian City, Putian, Fujian Province, China. FAU - Lin, Lixian AU - Lin L AD - Department of Internal Medicine, The First Hospital of Putian City, Putian, Fujian Province, China. LLX514030811@outlook.com. LA - eng PT - Journal Article DEP - 20250526 PL - England TA - BMC Cardiovasc Disord JT - BMC cardiovascular disorders JID - 100968539 RN - 0 (Triglycerides) RN - 0 (Biomarkers) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - *Hypertension/epidemiology/diagnosis/physiopathology/blood MH - Cross-Sectional Studies MH - Male MH - Female MH - Adult MH - Middle Aged MH - *Triglycerides/blood MH - Biomarkers/blood MH - *Blood Glucose/analysis/metabolism MH - Nutrition Surveys MH - Prevalence MH - Young Adult MH - *Waist-Height Ratio MH - Adolescent MH - United States/epidemiology MH - Risk Factors MH - Risk Assessment MH - Predictive Value of Tests MH - Age Factors MH - *Blood Pressure PMC - PMC12105317 OTO - NOTNLM OT - Hypertension OT - NHANES OT - Triglyceride glucose index OT - TyG OT - TyG-WHtR COIS- Declarations. Ethics approval and consent to participate: The National Health and Nutrition Examination Survey (NHANES) protocol was approved by the National Center for Health Statistics Institutional Ethics Review Board, and the current study did not involve any personally identifiable information, thus exempting it from further ethical review. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/05/27 00:28 MHDA- 2025/05/27 06:27 PMCR- 2025/05/26 CRDT- 2025/05/26 23:38 PHST- 2025/03/01 00:00 [received] PHST- 2025/05/12 00:00 [accepted] PHST- 2025/05/27 06:27 [medline] PHST- 2025/05/27 00:28 [pubmed] PHST- 2025/05/26 23:38 [entrez] PHST- 2025/05/26 00:00 [pmc-release] AID - 10.1186/s12872-025-04853-y [pii] AID - 4853 [pii] AID - 10.1186/s12872-025-04853-y [doi] PST - epublish SO - BMC Cardiovasc Disord. 2025 May 26;25(1):403. doi: 10.1186/s12872-025-04853-y. PMID- 40419161 OWN - NLM STAT- MEDLINE DCOM- 20250608 LR - 20250608 IS - 1573-2517 (Electronic) IS - 0165-0327 (Linking) VI - 386 DP - 2025 Oct 1 TI - Exploring the Association of dietary index for gut microbiota with Parkinson's disease and depression: Insights from NHANES. PG - 119461 LID - S0165-0327(25)00903-6 [pii] LID - 10.1016/j.jad.2025.119461 [doi] AB - BACKGROUND: Depression and Parkinson's disease (PD) are important public health issues strongly associated with diet and gut microbiota. The aim of this study was to investigate the association of the dietary index for gut microbiota (DI-GM) with Parkinson's disease and depression. METHODS: This cross-sectional study used data from the National Health and Nutrition Examination Survey (NHANES) database (2007-2020), with a total of 26,473 participants aged 18-80 years, weighted to represent 256 million US adults. Dietary recall data were used to calculate the DI-GM. Weighted logistic regression was used to analyze the relationship between the DI-GM and depression and PD, and to explore the potential mediating role of the DI-GM in depression and PD. Subgroup analyses and restricted cubic spline (RCS) analyses were also performed. RESULTS: The weighted prevalence of PD combined with depression was approximately 22.99 %. We found a possible inverted U-shaped relationship between DI-GM and depression. Higher DI-GM scores were associated with a lower risk of PD (OR = 0.84, 95 % CI (0.75,0.94)). Mediation modelling indicated no significant role for DI-GM in the relationship between depression and PD. The RCS showed a non-linear association between DI-GM and PD. CONCLUSIONS: A dose-dependent nonlinear association was identified between the DI-GM and PD. Preliminary evidence suggests a potential inverted U-shaped DI-GM-depression relationship requiring validation. This suggests that focusing on DI-GM may be helpful in studying PD and depression. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Shu, Yanping AU - Shu Y AD - Department of Psychiatry of Women and Children, The Second People's Hospital of Guizhou Province, Guiyang, China. FAU - Hong, Wei AU - Hong W AD - Department of Neurology, Taizhou People's Hospital Affiliated to Nanjing Medical University, Taizhou, China. FAU - Liu, Jiaoying AU - Liu J AD - Department of Psychiatry of Women and Children, The Second People's Hospital of Guizhou Province, Guiyang, China. FAU - Zhu, Xianlin AU - Zhu X AD - Department of Clinical Psychology, Huizhou No.2 Hospital, Huizhou, China. Electronic address: 2509655747@qq.com. LA - eng PT - Journal Article DEP - 20250524 PL - Netherlands TA - J Affect Disord JT - Journal of affective disorders JID - 7906073 SB - IM MH - Humans MH - *Parkinson Disease/epidemiology/microbiology MH - Male MH - Middle Aged MH - Female MH - Aged MH - Adult MH - Cross-Sectional Studies MH - *Gastrointestinal Microbiome/physiology MH - Nutrition Surveys MH - Adolescent MH - Aged, 80 and over MH - Young Adult MH - *Diet/statistics & numerical data MH - *Depression/epidemiology/microbiology MH - United States/epidemiology OTO - NOTNLM OT - DI-GM OT - Depression OT - Gut microbiota OT - NHANES OT - Parkinson's disease COIS- Declaration of competing interest The authors declare no conflicts of interest. EDAT- 2025/05/27 00:28 MHDA- 2025/06/09 00:28 CRDT- 2025/05/26 19:35 PHST- 2024/11/10 00:00 [received] PHST- 2025/05/20 00:00 [revised] PHST- 2025/05/23 00:00 [accepted] PHST- 2025/06/09 00:28 [medline] PHST- 2025/05/27 00:28 [pubmed] PHST- 2025/05/26 19:35 [entrez] AID - S0165-0327(25)00903-6 [pii] AID - 10.1016/j.jad.2025.119461 [doi] PST - ppublish SO - J Affect Disord. 2025 Oct 1;386:119461. doi: 10.1016/j.jad.2025.119461. Epub 2025 May 24. PMID- 40413319 OWN - NLM STAT- MEDLINE DCOM- 20260220 LR - 20260806 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) VI - 99 IP - 1 DP - 2026 Jan TI - Association of maternal dietary diversity during pregnancy and infant lower respiratory tract infections. PG - 143-149 LID - 10.1038/s41390-025-04125-7 [doi] AB - BACKGROUND: A varied diet during pregnancy benefits development of the fetus, but its impact on the infant respiratory health is less well-known. This study prospectively examines the association between the maternal Minimum Dietary Diversity for Women (MDD-W) score and the risk of lower respiratory tract infections (LRTIs) in infants. METHODS: This study included 2588 women in Wuhan, China. Dietary intake was assessed using validated food frequency questionnaires. All food items were categorized into 10 groups based on guidance from the Food and Agriculture Organization to construct the MDD-W score. Infant LRTIs were recorded at 3-, 6-, and 12-months postpartum follow-ups. RESULTS: In the study, 347 (13.4%) infants with LRTIs during the first year. Maternal MDD-W score /=9. When the outcome was further subdivided into LRTIs at 0-6 months and 6-12 months of age, this association was only present at 0-6 months of age (RR: 2.02; 95% CI: 1.31, 3.10). CONCLUSIONS: Our results suggest that low maternal dietary diversity is associated with a higher risk of infant LRTIs. IMPACT: Diversified diet during pregnancy benefits the fetus's development, but few studies have demonstrated the effect of dietary diversity during pregnancy on the infant respiratory health. In this longitudinal cohort in China, we found that a varied diet during pregnancy was associated with a lower risk of infant lower respiratory tract infections, the association remained regardless of whether infants breastfed. An intervention to increase maternal dietary diversity should be carefully considered. CI - (c) 2025. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - Liang, Qian AU - Liang Q AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China. FAU - Wang, Weiming AU - Wang W AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China. FAU - Liu, Jin AU - Liu J AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China. FAU - Chen, Xi AU - Chen X AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China. FAU - Li, Na AU - Li N AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China. FAU - Zhang, Longyu AU - Zhang L AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China. FAU - Xiong, Guoping AU - Xiong G AD - Department of Obstetrics and Gynecology, The Central Hospital of Wuhan, Wuhan, Hubei, China. FAU - Sun, Guoqiang AU - Sun G AD - Department of Obstetrics and Gynecology, Maternal and Child Health Care Hospital of Hubei Province, Wuhan, Hubei, China. FAU - Yang, Hongying AU - Yang H AD - Hubei Center for Disease Control and Prevention, Wuhan, Hubei, China. FAU - Yang, Xuefeng AU - Yang X AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China. FAU - Hao, Liping AU - Hao L AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China. FAU - Yang, Nianhong AU - Yang N AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China. zynh@mails.tjmu.edu.cn. LA - eng PT - Journal Article DEP - 20250524 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM MH - Humans MH - Female MH - *Respiratory Tract Infections/epidemiology MH - Pregnancy MH - Infant MH - China/epidemiology MH - *Diet MH - Prospective Studies MH - Infant, Newborn MH - Adult MH - Risk Factors MH - Male MH - *Maternal Nutritional Physiological Phenomena MH - Young Adult COIS- Competing interests: The authors declare no competing interest. Ethics approval and consent to participate: Informed consents were obtained from all participants at enrollment. The Ethics Review Committee of Tongji Medical College, Huazhong University of Science and Technology approved this study (No. 201302). EDAT- 2025/05/25 20:36 MHDA- 2026/02/20 07:05 CRDT- 2025/05/24 23:22 PHST- 2024/08/09 00:00 [received] PHST- 2025/04/17 00:00 [accepted] PHST- 2025/03/27 00:00 [revised] PHST- 2026/02/20 07:05 [medline] PHST- 2025/05/25 20:36 [pubmed] PHST- 2025/05/24 23:22 [entrez] AID - 10.1038/s41390-025-04125-7 [pii] AID - 10.1038/s41390-025-04125-7 [doi] PST - ppublish SO - Pediatr Res. 2026 Jan;99(1):143-149. doi: 10.1038/s41390-025-04125-7. Epub 2025 May 24. PMID- 40410302 OWN - NLM STAT- MEDLINE DCOM- 20250523 LR - 20260924 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 May 23 TI - Psychometric properties of the Lithuanian version of the functionality appreciation scale. PG - 17952 LID - 10.1038/s41598-025-03349-1 [doi] LID - 17952 AB - This study aimed to assess the psychometric properties of the Lithuanian translation of the Functionality Appreciation Scale (FAS). A sample (n = 759) of adults (424 women and 335 men; mean age 23.2 +/- 7.1 and age range 18-44 years) participated in the cross-sectional study. Body functionality appreciation, body appreciation, self-esteem, disordered eating and physical activity habits were assessed. Exploratory factor analysis (EFA; n = 379) identified a unidimensional factor structure of FAS, supported by findings in a second split-subsample using confirmatory factor analysis (CFA, n = 380). FAS scores were invariant across gender groups. No mean score differences were observed between genders. Composite reliability of FAS was established in women (omega = 0.94, 95% CI = 0.92, 0.95) and men (omega = 0.92, 95% CI = 0.90, 0.94). Positive associations of FAS with body appreciation, self-esteem and physical activity habits and negative relationships with disordered eating and BMI (in women) confirmed construct validity. FAS predicted self-esteem over and above the variance accounted for by other study measures. The Lithuanian version of FAS is a psychometrically sound measure of body functionality appreciation. FAS might contribute to a comprehensive assessment of positive body image and can be used in various interventions. CI - (c) 2025. The Author(s). FAU - Baceviciene, Migle AU - Baceviciene M AD - Department of Physical and Social Education, Lithuanian Sports University, Sporto 6, Kaunas, 44221, Lithuania. migle.baceviciene@lsu.lt. FAU - Balciuniene, Vaiva AU - Balciuniene V AD - Department of Physical and Social Education, Lithuanian Sports University, Sporto 6, Kaunas, 44221, Lithuania. FAU - Jankauskiene, Rasa AU - Jankauskiene R AD - Institute of Sport Science and Innovations, Lithuanian Sports University, Sporto 6, Kaunas, 44221, Lithuania. LA - eng GR - S-MIP-22-25/Lietuvos Mokslo Taryba/ GR - S-MIP-22-25/Lietuvos Mokslo Taryba/ GR - S-MIP-22-25/Lietuvos Mokslo Taryba/ PT - Journal Article DEP - 20250523 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Male MH - Adult MH - *Psychometrics/methods MH - Lithuania MH - Adolescent MH - Young Adult MH - Cross-Sectional Studies MH - *Body Image/psychology MH - Self Concept MH - Surveys and Questionnaires MH - Reproducibility of Results MH - Exercise MH - Feeding and Eating Disorders/psychology PMC - PMC12102171 OTO - NOTNLM OT - Appreciation OT - Body functionality OT - Factor structure OT - Lithuanian OT - Positive body image OT - Psychometrics COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/05/24 00:45 MHDA- 2025/05/24 00:46 PMCR- 2025/05/23 CRDT- 2025/05/23 23:23 PHST- 2024/12/19 00:00 [received] PHST- 2025/05/20 00:00 [accepted] PHST- 2025/05/24 00:46 [medline] PHST- 2025/05/24 00:45 [pubmed] PHST- 2025/05/23 23:23 [entrez] PHST- 2025/05/23 00:00 [pmc-release] AID - 10.1038/s41598-025-03349-1 [pii] AID - 3349 [pii] AID - 10.1038/s41598-025-03349-1 [doi] PST - epublish SO - Sci Rep. 2025 May 23;15(1):17952. doi: 10.1038/s41598-025-03349-1. PMID- 40407241 OWN - NLM STAT- Publisher LR - 20250523 IS - 2168-6602 (Electronic) IS - 0890-1171 (Linking) DP - 2025 May 23 TI - Physical Activity, Social Media Use, Anxiety, Interoception, and Body Image: A Cross-Sectional Study of Rural Adolescents. PG - 8901171251346391 LID - 10.1177/08901171251346391 [doi] AB - PurposeThis investigation aimed to explore relationships among health behaviors, psychological factors, and body image in rural adolescents.DesignA cross-sectional survey was conducted. Setting: The study took place in a rural school in the Midwest region of the United States.SubjectsParticipants (n = 45) were rural adolescents (6th-9th grade).MeasuresPhysical activity was assessed using the CAPL-2 and IPAQ, social media usage and addiction were evaluated through daily screen time and the BSMAS, body image was measured using the BSQ and BAS-2, anxiety levels were assessed with the GAD-7, and interoceptive abilities were measured by the MAIA-Y. These measures are validated for use in adolescent populations.AnalysisLinear regression models examined relationships between physical activity, social media usage, anxiety, body image, and interoceptive abilities. Effect sizes for significant predictors were determined using Cohen's d.ResultsNovel relationships were identified among rural adolescents, including a positive association between body appreciation and physical literacy (d = 0.322, P = 0.002), a negative association between body appreciation and social media addiction (d = 0.866, P < 0.001), and a positive association between social media addiction and anxiety levels (d = 0.341, P < 0.001).ConclusionSocial media impacts the well-being of rural adolescents. Promoting physical literacy and social media literacy may mitigate negative effects and should be prioritized in future interventions. FAU - Watkins, Janette M AU - Watkins JM AUID- ORCID: 0009-0001-5968-8730 AD - Department of Kinesiology, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA. RINGGOLD: 41473 AD - Program in Neuroscience, College of Arts and Sciences, Indiana University, Bloomington, IN, USA. RINGGOLD: 123992 FAU - Goss, Janelle M AU - Goss JM AD - Department of Kinesiology, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA. RINGGOLD: 41473 FAU - Martinez Kercher, Vanessa M AU - Martinez Kercher VM AUID- ORCID: 0000-0002-0498-5279 AD - Department of Health & Wellness Design, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA. RINGGOLD: 41473 FAU - Coble, Cassandra J AU - Coble CJ AD - Department of Kinesiology, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA. RINGGOLD: 41473 FAU - Hobson, James M AU - Hobson JM AD - White River Valley Middle School, Lyons, IN, USA. RINGGOLD: 324265 FAU - Steinfeldt, Jesse A AU - Steinfeldt JA AD - Department of Counseling and Educational Psychology-Bloomington, Indiana University, Bloomington, IN, USA. RINGGOLD: 216419 FAU - Koceja, David M AU - Koceja DM AD - Department of Kinesiology, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA. RINGGOLD: 41473 AD - Program in Neuroscience, College of Arts and Sciences, Indiana University, Bloomington, IN, USA. RINGGOLD: 123992 FAU - Wisner, Krista M AU - Wisner KM AD - Department of Psychological & Brain Science, College of Arts and Sciences, Indiana University, Bloomington, IN, USA. RINGGOLD: 123992 FAU - Kercher, Kyle A AU - Kercher KA AD - Department of Kinesiology, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA. RINGGOLD: 41473 LA - eng PT - Journal Article DEP - 20250523 PL - United States TA - Am J Health Promot JT - American journal of health promotion : AJHP JID - 8701680 SB - IM OTO - NOTNLM OT - intervention design OT - media literacy OT - rural health EDAT- 2025/05/23 12:29 MHDA- 2025/05/23 12:29 CRDT- 2025/05/23 08:22 PHST- 2025/05/23 12:29 [medline] PHST- 2025/05/23 12:29 [pubmed] PHST- 2025/05/23 08:22 [entrez] AID - 10.1177/08901171251346391 [doi] PST - aheadofprint SO - Am J Health Promot. 2025 May 23:8901171251346391. doi: 10.1177/08901171251346391. PMID- 40406888 OWN - NLM STAT- MEDLINE DCOM- 20250801 LR - 20250804 IS - 1471-0528 (Electronic) IS - 1470-0328 (Linking) VI - 132 IP - 10 DP - 2025 Sep TI - Construction of a Prediction Model for Adverse Perinatal Outcomes in Foetal Growth Restriction Based on a Machine Learning Algorithm: A Retrospective Study. PG - 1514-1523 LID - 10.1111/1471-0528.18226 [doi] AB - OBJECTIVE: To create and validate a machine learning (ML)-based model for predicting the adverse perinatal outcome (APO) in foetal growth restriction (FGR) at diagnosis. DESIGN: A retrospective study. SETTING: Multi-centre in China. POPULATION: Pregnancies affected by FGR. METHODS: We enrolled singleton foetuses with a perinatal diagnosis of FGR who were admitted between January 2021 and November 2023. A total of 361 pregnancies from Beijing Obstetrics and Gynecology Hospital were used as the training set and the internal test set. In comparison, data from 50 pregnancies from Haidian Maternal and Child Health Hospital were used as the external test set. Feature screening was performed using the random forest (RF), the Least Absolute Shrinkage and Selection Operator (LASSO) and logistic regression (LR). Subsequently, six ML methods, including Stacking, were used to construct models to predict the APO of FGR. MAIN OUTCOME MEASURES: Model's performance was evaluated through indicators such as the area under the receiver operating characteristic curve (AUROC). The Shapley Additive Explanation analysis was used to rank each model feature and explain the final model. RESULTS: Mean +/- SD gestational age at diagnosis was 32.3 +/- 4.8 weeks in the absent APO group and 27.3 +/- 3.7 in the present APO group. Women enrolled in the present APO group had a higher rate of hypertension related to pregnancy (74.8% vs. 18.8%, p < 0.001). Among 17 candidate predictors (including maternal characteristics, maternal comorbidities, obstetric characteristics and ultrasound parameters), the integration of RF, LASSO and LR methodologies identified maternal body mass index, hypertension, gestational age at diagnosis of FGR, estimated foetal weight (EFW) z score, EFW growth velocity and abnormal umbilical artery Doppler (defined as a pulsatility index above the 95th percentile or instances of absent/reversed diastolic flow) as significant predictors. The Stacking model demonstrated a good performance in both the internal test set [AUROC: 0.861, 95% confidence interval (CI), 0.838-0.896] and the external test set [AUROC: 0.906, 95% CI, 0.875-0.947]. The calibration curve showed high agreement between the predicted and observed risks. The Hosmer-Lemeshow test for the internal and external test sets was p = 0.387 and p = 0.825, respectively. CONCLUSIONS: The ML algorithm for APO, which integrates maternal clinical factors and ultrasound parameters, demonstrates good predictive value for APO in FGR at diagnosis. This suggested that ML techniques may be a valid approach for the early detection of high-risk APO in FGR pregnancies. CI - (c) 2025 John Wiley & Sons Ltd. FAU - Meng, Xiangli AU - Meng X AD - Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China. AD - Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Wang, Lei AU - Wang L AD - Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China. AD - Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Wu, Minghui AU - Wu M AD - Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China. AD - Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Zhang, Na AU - Zhang N AD - Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China. AD - Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Li, Xiaofei AU - Li X AD - Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China. AD - Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Wu, Qingqing AU - Wu Q AUID- ORCID: 0000-0002-6836-9192 AD - Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China. AD - Beijing Maternal and Child Health Care Hospital, Beijing, China. LA - eng GR - Beijing Municipal Health Commission, demonstration construction project of Clinical Research ward/ GR - National Key Research and Development Program of China/ PT - Journal Article PT - Multicenter Study DEP - 20250523 PL - England TA - BJOG JT - BJOG : an international journal of obstetrics and gynaecology JID - 100935741 SB - IM MH - Humans MH - Female MH - *Fetal Growth Retardation/diagnosis/epidemiology MH - Pregnancy MH - Retrospective Studies MH - *Machine Learning MH - Adult MH - China/epidemiology MH - Pregnancy Outcome/epidemiology MH - Gestational Age MH - Algorithms MH - Ultrasonography, Prenatal MH - Infant, Newborn MH - ROC Curve MH - Predictive Value of Tests OTO - NOTNLM OT - growth restriction OT - machine learning OT - nomogram OT - perinatal morbidity and mortality OT - predictive model OT - small-for-gestational age EDAT- 2025/05/23 06:26 MHDA- 2025/08/01 12:32 CRDT- 2025/05/23 05:13 PHST- 2025/03/18 00:00 [revised] PHST- 2025/01/13 00:00 [received] PHST- 2025/05/05 00:00 [accepted] PHST- 2025/08/01 12:32 [medline] PHST- 2025/05/23 06:26 [pubmed] PHST- 2025/05/23 05:13 [entrez] AID - 10.1111/1471-0528.18226 [doi] PST - ppublish SO - BJOG. 2025 Sep;132(10):1514-1523. doi: 10.1111/1471-0528.18226. Epub 2025 May 23. PMID- 40406666 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250525 IS - 2253-5969 (Print) IS - 2253-5969 (Electronic) IS - 2253-5969 (Linking) VI - 12 DP - 2025 TI - Radiomics of Dynamic Contrast-Enhanced MRI for Predicting Radiation-Induced Hepatic Toxicity After Intensity Modulated Radiotherapy for Hepatocellular Carcinoma: A Machine Learning Predictive Model Based on the SHAP Methodology. PG - 999-1015 LID - 10.2147/JHC.S523448 [doi] AB - OBJECTIVE: To develop an interpretable machine learning (ML) model using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) radiomic data, dosimetric parameters, and clinical data for predicting radiation-induced hepatic toxicity (RIHT) in patients with hepatocellular carcinoma (HCC) following intensity-modulated radiation therapy (IMRT). METHODS: A retrospective analysis of 150 HCC patients was performed, with a 7:3 ratio used to divide the data into training and validation cohorts. Radiomic features from the original MRI sequences and Delta-radiomic features were extracted. Seven ML models based on radiomics were developed: logistic regression (LR), random forest (RF), support vector machine (SVM), eXtreme Gradient Boosting (XGBoost), adaptive boosting (AdaBoost), decision tree (DT), and artificial neural network (ANN). The predictive performance of the models was evaluated using receiver operating characteristic (ROC) curve analysis and calibration curves. Shapley additive explanations (SHAP) were employed to interpret the contribution of each variable and its risk threshold. RESULTS: Original radiomic features and Delta-radiomic features were extracted from DCE-MRI images and filtered to generate Radiomics-scores and Delta-Radiomics-scores. These were then combined with independent risk factors (Body Mass Index (BMI), V5, and pre-Child-Pugh score(pre-CP)) identified through univariate and multivariate logistic regression and Spearman correlation analysis to construct the ML models. In the training cohort, the AUC values were 0.8651 for LR, 0.7004 for RF, 0.6349 for SVM, 0.6706 for XGBoost, 0.7341 for AdaBoost, 0.6806 for Decision Tree, and 0.6786 for ANN. The corresponding accuracies were 84.4%, 65.6%, 75.0%, 65.6%, 71.9%, 68.8%, and 71.9%, respectively. The validation cohort further confirmed the superiority of the LR model, which was selected as the optimal model. SHAP analysis revealed that Delta-radiomics made a substantial positive contribution to the model. CONCLUSION: The interpretable ML model based on radiomics provides a non-invasive tool for predicting RIHT in patients with HCC, demonstrating satisfactory discriminative performance. CI - (c) 2025 Liu et al. FAU - Liu, Fushuang AU - Liu F AD - Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, 530001, People's Republic of China. FAU - Chen, Lijun AU - Chen L AD - Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, 530001, People's Republic of China. FAU - Wu, Qiaoyuan AU - Wu Q AD - Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, 530001, People's Republic of China. FAU - Li, Liqing AU - Li L AUID- ORCID: 0000-0002-2987-0259 AD - Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, 530001, People's Republic of China. FAU - Li, Jizhou AU - Li J AUID- ORCID: 0009-0004-9609-7819 AD - Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, 530001, People's Republic of China. FAU - Su, Tingshi AU - Su T AD - Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, 530001, People's Republic of China. FAU - Li, Jianxu AU - Li J AD - Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, 530001, People's Republic of China. FAU - Liang, Shixiong AU - Liang S AUID- ORCID: 0009-0007-7167-6074 AD - Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, 530001, People's Republic of China. FAU - Qing, Liping AU - Qing L AD - Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, 530001, People's Republic of China. LA - eng PT - Journal Article DEP - 20250517 PL - New Zealand TA - J Hepatocell Carcinoma JT - Journal of hepatocellular carcinoma JID - 101674775 PMC - PMC12095435 OTO - NOTNLM OT - MRI OT - hepatocellular carcinoma OT - machine learning OT - radiation-induced hepatic toxicity OT - radiomics COIS- The authors declare no competing interests in this work. EDAT- 2025/05/23 06:26 MHDA- 2025/05/23 06:27 PMCR- 2025/05/17 CRDT- 2025/05/23 04:45 PHST- 2025/02/18 00:00 [received] PHST- 2025/05/03 00:00 [accepted] PHST- 2025/05/23 06:27 [medline] PHST- 2025/05/23 06:26 [pubmed] PHST- 2025/05/23 04:45 [entrez] PHST- 2025/05/17 00:00 [pmc-release] AID - 523448 [pii] AID - 10.2147/JHC.S523448 [doi] PST - epublish SO - J Hepatocell Carcinoma. 2025 May 17;12:999-1015. doi: 10.2147/JHC.S523448. eCollection 2025. PMID- 40406080 OWN - NLM STAT- MEDLINE DCOM- 20250523 LR - 20250525 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - School-based peer education intervention on physical activity in Iranian adolescent girls: an application of the theory of planned behavior. PG - 1558210 LID - 10.3389/fpubh.2025.1558210 [doi] LID - 1558210 AB - INTRODUCTION: The level of physical activity (PA) among Iranian adolescent girls is significantly lower than the recommended level. This survey aims to examine the impact of school-based peer education Intervention on promoting PA using the theory of planned behavior (TPB) among girls in high school. METHODS: A quasi-experimental study was conducted on 160 girls in high school of Gonabad, Iran. School-based peer education program was conducted for the intervention group through five training sessions and the three-month follow-up to enhance clarity. Data was collected using a researcher-made questionnaire based on TPB, the International Physical Activity Questionnaire (IPAQ), and demographic information. The content validity Index, content validity ratio, and Cronbach's alpha coefficient values demonstrated strong content validity and reliability (> 0.85). The obtained data were analyzed using appropriate statistical tests using SPSS software 20. RESULTS: The average age of the participants was 13.5 +/- 1.2 years, and 65% had low levels of PA. The intervention group demonstrated significant improvements across all constructs of the TPB compared to the control group. The mean scores for attitude toward behavior (p = 0.012), subjective norms (p = 0.023), perceived behavioral control (p = 0.003), and behavioral intention (p = 0.001) showed significant enhancement in the intervention group. Additionally, physical activity behavior improved significantly (p < 0.05) after the intervention, while no significant improvement was observed in the control group (p > 0.05). The Cohen's d values for all constructs in the intervention group, except for subjective norms, exceeded 0.8, indicating a large effect size for these constructs. CONCLUSION: School-based peer education using the TPB can be used as an effective theory to promote the level of PA among high school girls. This approach strengthens attitudes, perceived behavioral control, and subjective norms, leading to improved behavioral intentions and increased PA among female students. CI - Copyright (c) 2025 Ranaei, Tavakoly Sany, Vahedian Shahroodi, Sabahi, Tehrani and Khajavi. FAU - Ranaei, Afsaneh AU - Ranaei A AD - School of Health, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Tavakoly Sany, Seyedeh Belin AU - Tavakoly Sany SB AD - Department of Health, Safety, Environment, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Vahedian Shahroodi, Mohammad AU - Vahedian Shahroodi M AD - Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Department of Health Education and Health Promotion, Faculty of Health, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Sabahi, Azam AU - Sabahi A AD - Department of Health Information Technology, Ferdows Faculty of Medical Sciences, Birjand University of Medical Sciences, Birjand, Iran. FAU - Tehrani, Hadi AU - Tehrani H AD - Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Department of Health Education and Health Promotion, Faculty of Health, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Khajavi, Abdoljavad AU - Khajavi A AD - Department of Family and Community Medicine, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran. LA - eng PT - Journal Article DEP - 20250507 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Female MH - Iran MH - Adolescent MH - *Peer Group MH - *Exercise/psychology MH - Surveys and Questionnaires MH - Schools MH - *Health Education/methods MH - *Health Promotion/methods MH - *School Health Services/organization & administration MH - Adolescent Behavior/psychology MH - Theory of Planned Behavior PMC - PMC12096170 OTO - NOTNLM OT - health education OT - health promotion OT - peer education OT - physical activity OT - public health COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/05/23 11:04 MHDA- 2025/05/23 11:05 PMCR- 2025/05/07 CRDT- 2025/05/23 04:37 PHST- 2025/01/09 00:00 [received] PHST- 2025/04/22 00:00 [accepted] PHST- 2025/05/23 11:05 [medline] PHST- 2025/05/23 11:04 [pubmed] PHST- 2025/05/23 04:37 [entrez] PHST- 2025/05/07 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1558210 [doi] PST - epublish SO - Front Public Health. 2025 May 7;13:1558210. doi: 10.3389/fpubh.2025.1558210. eCollection 2025. PMID- 40405094 OWN - NLM STAT- MEDLINE DCOM- 20250523 LR - 20250525 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 May 22 TI - Study on reference value of waist circumference percentile curve and abdominal obesity cutoff points of children and adolescents aged 6-20 in Macao. PG - 1889 LID - 10.1186/s12889-025-23015-5 [doi] LID - 1889 AB - BACKGROUND: To develop a standardized percentile curve of waist circumference and abdominal obesity cutoff points for children and adolescents aged 6 to 20 in Macao, the study established a reference for screening abdominal obesity in this population. METHODS: The waist circumference data of 10,095 children and adolescents from the 2015-2020 Macao People's Physical Fitness Surveys were used for modeling. The GAMLSS model with four parameters of "median, standard deviation, kurtosis and skewness" was used to construct the standardized percentile curve of waist circumference. Then, the percentile curve-joining adult method was applied to establish the critical value of high waist circumference. Finally, the curves of this study were compared with relevant domestic and international data. RESULTS: (1) Standard curves of waist circumference percentile and standard deviation unit curves were obtained for children and adolescents aged 6-20 years in Macao. (2) Waist circumference of children and adolescents in Macao increased with age. After the age of 12, waist circumference growth gradually decreased. The waist circumference of males was larger than that of females. (3) Analysis of different percentile curves revealed a divergence in growth rates between P50 and P90. Specifically, from ages 6-11 in boys and 6-10 in girls, the annual increase in waist circumference at P90 exceeded that at P50. After these ages, the growth rate at P50 surpassed that at P90. CONCLUSION: The standardized curves constructed for the percentile waist circumference of Macao's children and adolescents were smooth and tests showed good validity. We recommend using these standardized percentile curves (applicable to ages 6-20 years) and abdominal obesity thresholds (applicable to ages 6-18 years), combined with the other evaluation commonly used indicator of obesity, to identify abdominal obesity in Macao's children and adolescents and therefore, to improve the well-being of Macao's children and adolescents. CI - (c) 2025. The Author(s). FAU - Jiang, Lupei AU - Jiang L AD - China Institute of Sport Science, Stadium Road, Dongcheng District, Beijing on the 11th Zip, 100061, Beijing, China. FAU - Zhang, Aoyu AU - Zhang A AD - China Institute of Sport Science, Stadium Road, Dongcheng District, Beijing on the 11th Zip, 100061, Beijing, China. FAU - Tu, Chunjing AU - Tu C AD - School of Teacher (Physical) Education, Taizhou University, Taizhou, China. FAU - Gao, Yibo AU - Gao Y AD - China Institute of Sport Science, Stadium Road, Dongcheng District, Beijing on the 11th Zip, 100061, Beijing, China. FAU - He, Jin AU - He J AD - China Institute of Sport Science, Stadium Road, Dongcheng District, Beijing on the 11th Zip, 100061, Beijing, China. FAU - Pan, Xiang AU - Pan X AD - China Institute of Sport Science, Stadium Road, Dongcheng District, Beijing on the 11th Zip, 100061, Beijing, China. FAU - Zhang, Xuehui AU - Zhang X AD - College of Physical Education Science, Hefei Normal University, Hefei, China. FAU - Zhang, Yanfeng AU - Zhang Y AD - China Institute of Sport Science, Stadium Road, Dongcheng District, Beijing on the 11th Zip, 100061, Beijing, China. zhangyanfeng@ciss.cn. LA - eng GR - (No. B2117/The Fourth Technical Work Agreement on Physical Fitness Monitoring of Macao Citizens in 2020/ GR - (No. B2117/The Fourth Technical Work Agreement on Physical Fitness Monitoring of Macao Citizens in 2020/ GR - (No. B2117/The Fourth Technical Work Agreement on Physical Fitness Monitoring of Macao Citizens in 2020/ GR - (No. B2117/The Fourth Technical Work Agreement on Physical Fitness Monitoring of Macao Citizens in 2020/ GR - (No. B2117/The Fourth Technical Work Agreement on Physical Fitness Monitoring of Macao Citizens in 2020/ GR - (No. B2117/The Fourth Technical Work Agreement on Physical Fitness Monitoring of Macao Citizens in 2020/ GR - (No. B2117/The Fourth Technical Work Agreement on Physical Fitness Monitoring of Macao Citizens in 2020/ GR - (No. B2117/The Fourth Technical Work Agreement on Physical Fitness Monitoring of Macao Citizens in 2020/ PT - Journal Article DEP - 20250522 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Adolescent MH - Child MH - *Waist Circumference MH - Male MH - Female MH - *Obesity, Abdominal/diagnosis/epidemiology MH - Reference Values MH - Young Adult MH - Macau/epidemiology MH - Pediatric Obesity/diagnosis PMC - PMC12096770 OTO - NOTNLM OT - Children and adolescents OT - GAMLSS model OT - Macao OT - Percentile curve OT - Waist COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of the China Institute of Sport Science (approval number: CISS-20190607). Written informed consent was obtained from individual or guardian participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/05/23 00:27 MHDA- 2025/05/23 07:09 PMCR- 2025/05/22 CRDT- 2025/05/22 23:35 PHST- 2023/08/28 00:00 [received] PHST- 2025/05/01 00:00 [accepted] PHST- 2025/05/23 07:09 [medline] PHST- 2025/05/23 00:27 [pubmed] PHST- 2025/05/22 23:35 [entrez] PHST- 2025/05/22 00:00 [pmc-release] AID - 10.1186/s12889-025-23015-5 [pii] AID - 23015 [pii] AID - 10.1186/s12889-025-23015-5 [doi] PST - epublish SO - BMC Public Health. 2025 May 22;25(1):1889. doi: 10.1186/s12889-025-23015-5. PMID- 40404960 OWN - NLM STAT- MEDLINE DCOM- 20251119 LR - 20261010 IS - 1867-0687 (Electronic) VI - 21 IP - 11 DP - 2025 Nov TI - Reliability and validity of the revised Chinese version of the Children's Sleep Habits Questionnaire (CSHQ-CH-R). PG - 1163-1174 LID - 10.1007/s12519-025-00915-5 [doi] AB - BACKGROUND: The Chinese version of the Children's Sleep Habits Questionnaire (CSHQ-CH) has been widely used in clinical practice and research since it was developed in 2007. This study aimed to examine the psychometric properties of the revised version (CSHQ-CH-R) and establish cut-off values for screening for sleep disturbances in Chinese preschool-aged and school-aged children. METHODS: A community sample of 3850 preschool and school-aged children aged 3-12 years were obtained from 6 kindergartens and 2 primary schools in Shanghai, Beijing and Chengdu, China, from December 2019 to February 2020. A clinical sample of 119 children aged 3-12 years who were diagnosed with sleep disorders were recruited from a tertiary pediatric hospital in Shanghai from September 2019 to November 2021. Caregivers completed the original 33 items of the CSHQ-CH plus an additional 15 items through an online platform. Item analysis was conducted to develop the CSHQ-CH-R, which included discriminative validity, redundancy and ambiguity. Internal consistency, interobserver reliability, test-retest reliability, concurrent validity (correlations with actigraphy) and discriminative validity were then analyzed. The cut-off values for both the full scale and subscale scores were generated by receiver operating characteristics. RESULTS: The final version of the CSHQ-CH-R included 30 items and 8 subscales. Three subscales (bedtime resistance, sleep duration and daytime sleepiness) were revised, and the other five subscales were unchanged from those of the CSHQ-CH. The internal consistency for the full scale was 0.83 for the community sample, and 0.73 for the clinical sample. The internal consistency ranged from 0.47 (sleep duration) to 0.72 (bedtime resistance) for the community sample, and 0.38 (sleep duration) to 0.83 (sleep-disordered breathing) for the clinical sample. The interobserver reliability for the full scale was 0.55, and ranged from 0.38 (parasomnias) to 0.74 (bedtime resistance) for the subscales. The test-retest reliability was 0.70 for the full scale, and ranged from 0.54 (sleep duration) to 0.78 (bedtime resistance) for the subscales. Concurrent validities against actigraphy were 0.62 and 0.33 for "time in bed" and "night sleep duration", respectively. The clinical sample scored higher than the community sample did for the full scale and subscales (P < 0.01). A cut-off total score of 44 was determined, with an area under the curve of 0.76, a sensitivity of 0.64, and a specificity of 0.76. To facilitate cross-cultural comparisons, psychometric properties and cut-off values for the CSHQ-CH with the original 33 items were also provided. CONCLUSION: The CSHQ-CH-R exhibits satisfactory to good psychometric properties, indicating its suitability for identifying sleep problems among Chinese preschool- and school-aged children. CI - (c) 2025. Children's Hospital, Zhejiang University School of Medicine. FAU - Deng, Yu-Jiao AU - Deng YJ AD - Department of Developmental and Behavioral Pediatrics, Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, 1678 Dongfang Road, Shanghai 200127, China. AD - Department of Neurology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Ministry of Education- Shanghai Key Laboratory of Children's Environmental Health, Shanghai, China. AD - Shanghai Center for Brain Science and Brain-Inspired Technology, Shanghai, China. FAU - Lin, Tong AU - Lin T AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Nanjing University of the Arts, Nanjing, China. FAU - Li, Wen AU - Li W AD - Department of Developmental and Behavioral Pediatrics, Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, 1678 Dongfang Road, Shanghai 200127, China. FAU - Jiang, Yan-Rui AU - Jiang YR AD - Department of Developmental and Behavioral Pediatrics, Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, 1678 Dongfang Road, Shanghai 200127, China. FAU - Zhang, Jing AU - Zhang J AD - Department of Pneumology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Wang, Hui-Shan AU - Wang HS AD - National Center for Women and Children's Health, China CDC, Beijing, China. FAU - Wang, Hong AU - Wang H AD - Sichuan Provincial Maternity and Child Health Care Hospital, Chengdu, China. FAU - Owens, Judith AU - Owens J AD - Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Wang, Guang-Hai AU - Wang GH AD - Department of Developmental and Behavioral Pediatrics, Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, 1678 Dongfang Road, Shanghai 200127, China. wang-guanghai@163.com. AD - Ministry of Education- Shanghai Key Laboratory of Children's Environmental Health, Shanghai, China. wang-guanghai@163.com. AD - Shanghai Center for Brain Science and Brain-Inspired Technology, Shanghai, China. wang-guanghai@163.com. AD - Shanghai Key Laboratory of Child Brain and Development, Shanghai, China. wang-guanghai@163.com. FAU - Jiang, Fan AU - Jiang F AUID- ORCID: 0000-0003-0634-101X AD - Department of Developmental and Behavioral Pediatrics, Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, 1678 Dongfang Road, Shanghai 200127, China. fanjiang@shsmu.edu.cn. AD - Ministry of Education- Shanghai Key Laboratory of Children's Environmental Health, Shanghai, China. fanjiang@shsmu.edu.cn. AD - Shanghai Center for Brain Science and Brain-Inspired Technology, Shanghai, China. fanjiang@shsmu.edu.cn. AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. fanjiang@shsmu.edu.cn. AD - Shanghai Key Laboratory of Child Brain and Development, Shanghai, China. fanjiang@shsmu.edu.cn. LA - eng GR - 82073568/National Natural Science Foundation of China/ GR - 82071493/National Natural Science Foundation of China/ GR - 82201645/National Natural Science Foundation of China/ GR - 2022XD056/Shanghai Municipal Health Commission/ GR - SHSMU-ZDCX20211900/Innovative Research Team of High-level Local University in Shanghai/ GR - SHSMU-ZDCX20211100/Innovative Research Team of High-level Local University in Shanghai/ GR - 23CGA18/Shanghai Municipal Education Commission/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250523 PL - Switzerland TA - World J Pediatr JT - World journal of pediatrics : WJP JID - 101278599 SB - IM MH - Humans MH - Reproducibility of Results MH - Male MH - Female MH - Child MH - Child, Preschool MH - Surveys and Questionnaires MH - China MH - Psychometrics MH - *Sleep Wake Disorders/diagnosis MH - *Sleep OTO - NOTNLM OT - Children's Sleep Habits Questionnaire OT - China OT - Cutoff value OT - Reliability OT - Sleep problems OT - Validity COIS- Declarations. Ethical approval: The parents provided electronic informed consent by checking the designated box in the online questionnaire system before completing the survey. The study was approved by the Ethics Committee of the Shanghai Children's Medical Center (SCMCIRB-K2018042). Conflict of interest: The authors have no potential conflicts of interest to disclose. EDAT- 2025/05/23 00:27 MHDA- 2025/11/19 06:32 CRDT- 2025/05/22 23:31 PHST- 2024/10/30 00:00 [received] PHST- 2025/04/15 00:00 [accepted] PHST- 2025/04/13 00:00 [revised] PHST- 2025/11/19 06:32 [medline] PHST- 2025/05/23 00:27 [pubmed] PHST- 2025/05/22 23:31 [entrez] AID - 10.1007/s12519-025-00915-5 [pii] AID - 10.1007/s12519-025-00915-5 [doi] PST - ppublish SO - World J Pediatr. 2025 Nov;21(11):1163-1174. doi: 10.1007/s12519-025-00915-5. Epub 2025 May 23. PMID- 40402937 OWN - NLM STAT- MEDLINE DCOM- 20250522 LR - 20261021 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 5 DP - 2025 TI - From physical self-esteem to sports participation: The mediating role of exercise motivation and social support in adolescents. PG - e0324588 LID - 10.1371/journal.pone.0324588 [doi] LID - e0324588 AB - OBJECTIVE: This study examines the mechanisms linking physical self-esteem to adolescents' sports participation, emphasizing the mediating roles of exercise motivation and social support. It aims to establish a comprehensive framework that integrates psychological and social factors to understand sports behavior among adolescents. METHOD: A total of 2,588 adolescents from various regions in China were surveyed using validated scales for physical self-esteem, exercise motivation, social support, and sports participation. Structural equation modeling (SEM) was used to assess direct, mediated, and sequential mediation effects. RESULTS: The analysis confirmed that physical self-esteem significantly predicts sports participation directly (beta = 0.094, p < 0.001). Exercise motivation and social support act as mediators, explaining 33.26% and 16.74% of the total effect, respectively. Sequential mediation analysis showed that physical self-esteem influences sports participation through the combined effects of exercise motivation and social support, contributing 29.61% to the total effect. Demographic analyses revealed that males, rural adolescents, and middle school students exhibit higher levels of self-esteem, motivation, and sports participation. Group differences were analyzed based on demographic variables, including gender, grade level, and family location. CONCLUSION: This study underscores the critical roles of psychological traits and social contexts in shaping adolescents' sports participation. By revealing the mediating and sequential mediation effects of exercise motivation and social support, the research highlights pathways for targeted interventions. Schools and communities should focus on enhancing physical self-esteem and fostering supportive social networks to encourage sports participation. Future studies should incorporate longitudinal designs and explore cultural and regional variations to extend these findings. CI - Copyright: (c) 2025 Peng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Peng, Bo AU - Peng B AD - Sports Training Academy, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Chen, Weisong AU - Chen W AD - Sports Training Academy, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Wang, Hongshen AU - Wang H AUID- ORCID: 0009-0007-8947-0234 AD - Sports Training Academy, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Yu, Ting AU - Yu T AD - Jingshan Primary School, Changshou, Chongqing, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250522 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Adolescent MH - Male MH - *Self Concept MH - Female MH - *Motivation MH - *Social Support MH - *Exercise/psychology MH - *Sports/psychology MH - China MH - Surveys and Questionnaires PMC - PMC12097568 COIS- The authors have declared that no competing interests exist. EDAT- 2025/05/22 18:27 MHDA- 2025/05/22 18:28 PMCR- 2025/05/22 CRDT- 2025/05/22 13:32 PHST- 2024/12/16 00:00 [received] PHST- 2025/04/28 00:00 [accepted] PHST- 2025/05/22 18:28 [medline] PHST- 2025/05/22 18:27 [pubmed] PHST- 2025/05/22 13:32 [entrez] PHST- 2025/05/22 00:00 [pmc-release] AID - PONE-D-24-57757 [pii] AID - 10.1371/journal.pone.0324588 [doi] PST - epublish SO - PLoS One. 2025 May 22;20(5):e0324588. doi: 10.1371/journal.pone.0324588. eCollection 2025. PMID- 40400893 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250523 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 17 IP - 4 DP - 2025 Apr TI - Primary Care Physicians' Attitudes and Practices in Managing Overweight and Obesity in Al-Ahsa, Saudi Arabia. PG - e82670 LID - 10.7759/cureus.82670 [doi] LID - e82670 AB - INTRODUCTION: Obesity is a prevalent health issue that affects countries globally, regardless of their level of development. In Saudi Arabia, both male and female individuals are experiencing a growing concern with obesity, which begins in childhood and persists into adulthood. Primary healthcare doctors play a crucial role in addressing this problem, as they are the initial point of contact and significant contributors to cost-efficient strategies for managing and preventing obesity. Aim: This study aims to determine the attitudes and practices of physicians working in primary health care centers regarding the management of overweight and obesity in Al-Ahsa, Saudi Arabia. Methods: This was a descriptive cross-sectional study conducted in the Al-Ahsa region of Saudi Arabia. The study involved 188 participants by multistage stratified cluster sampling through two stages. The first stage involved randomly selecting 27 centers from 66 centers, proportional to the number of doctors in each sector. The second phase involved randomly selecting doctors at each selected center. Data were collected using a validated, pretested, self-administered questionnaire and analyzed by IBM SPSS Statistics for Windows, Version 28.0 (Released 2021; IBM Corp., Armonk, New York, United States). We employed both descriptive and inferential statistics. RESULT: The study involved 188 participants, more than half (n=102, 54.3%) of whom were female, and 95 (50.5%) were aged 25-29 years. More than half (n=107, 56.9%) held board certificates, and 74 (39.4%) had bachelor's degrees. Over half (n=103, 54.8%) had less than three years of experience. A majority of participants (n=133, 70.70%) had a moderate attitude towards obesity, while 41 (21.8%) had a good attitude, and 14 (7.50%) had a bad attitude. Furthermore, more than two-thirds of them (67.50%) had moderate practice, while 37 (19.70%) had bad practice, and 24 (12.8%) had good practice. There was a significant relationship between sex and attitude, where male physicians had an attitude score higher than that of female physicians (29.86+/-3.43 vs 28.63+/-3.47) with a p-value of .016, and the study revealed a positive correlation between attitude and practice. CONCLUSION: Improving the attitude and practices of primary care physicians towards the management of overweight and obesity will lead to better health outcomes in overweight and obese patients. CI - Copyright (c) 2025, Alkhuwaysah et al. FAU - Alkhuwaysah, Mohammed A AU - Alkhuwaysah MA AD - Family Medicine, Alahsa Family Medicine Academy, Hofuf, SAU. FAU - Alsayegh, Hussain A AU - Alsayegh HA AD - Family Medicine, Alahsa Family Medicine Academy, Hofuf, SAU. FAU - Alsarhan, Maitham N AU - Alsarhan MN AD - Family Medicine, Alahsa Family Medicine Academy, Hofuf, SAU. LA - eng PT - Journal Article DEP - 20250421 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC12093192 OTO - NOTNLM OT - alahsa OT - attitude OT - attitude and practice of health care professionals OT - obesity OT - overweight OT - phc COIS- Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. IRB-KFHH No. H-05-HS-065 issued approval 46-EP-2024. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2025/05/22 06:28 MHDA- 2025/05/22 06:29 PMCR- 2025/04/21 CRDT- 2025/05/22 04:28 PHST- 2025/04/20 00:00 [accepted] PHST- 2025/05/22 06:29 [medline] PHST- 2025/05/22 06:28 [pubmed] PHST- 2025/05/22 04:28 [entrez] PHST- 2025/04/21 00:00 [pmc-release] AID - 10.7759/cureus.82670 [doi] PST - epublish SO - Cureus. 2025 Apr 21;17(4):e82670. doi: 10.7759/cureus.82670. eCollection 2025 Apr. PMID- 40399510 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250524 IS - 2199-1170 (Print) IS - 2198-9761 (Electronic) IS - 2198-9761 (Linking) VI - 11 IP - 1 DP - 2025 May 21 TI - Global Trends in the Relationship Between Chronic Air Pollution Exposure, Physical Activity and Lung Function in Youth Aged 5-18 Years With and Without Asthma: A Systematic Review. PG - 57 LID - 10.1186/s40798-025-00856-3 [doi] LID - 57 AB - BACKGROUND: Children are more susceptible to air pollution due, at least in part, to their less-developed respiratory systems and higher respiratory rates. Although the health benefits associated with physical activity are indisputable, there is considerable debate regarding whether increased exposure to, and deeper inhalation of, air pollution while being physically active negates such health benefits. OBJECTIVES: The aim was to explore the relationship between air pollution and lung function and the influence of asthma status and physical activity in children and adolescents. METHODS: Six databases were searched following PRISMA guidelines with no date restrictions: PubMed, Web of Science, MEDLINE, EMBASE, SPORTDiscus, and Cochrane Central Register of Controlled Trials (CENTRAL). Studies were included if they: i) studied children and adolescents (5-18 years); ii) were peer-reviewed; iii) were available in the English language; and iv) reported data using previously validated tools. RESULTS: From 12,161 original records, 16 studies were included in this review. The most widely examined pollutants were particulate matter PM(2.5)-PM(10), ozone (O(3)), nitrogen dioxide (NO(2)), nitrogen oxide (NO(X)), carbon monoxide (CO), and sulphur dioxide (SO(2)). Increased exposure to various air pollutants, particularly during outdoor physical activity, resulted in lung function deficits. This was especially evident in children and adolescents with asthma, dependent on the specific air pollutant. There was a consensus that forced expiratory volume in one second (FEV(1)) and forced vital capacity (FVC) decreased as air pollution concentrations increased. Notably, there was a reduction in FEV(1) at both three- and four-days post-exposure to CO, PM(10), and NO(2). CONCLUSIONS: There is a pressing need to reduce the impact of air pollution on lung function to improve health and realise the full benefits of physical activity. Given the potent and potentially long-term effects of air pollution, governments and local authorities must continue to reduce air pollution concentrations to improve the current and future health of populations globally. KEY POINTS: Increased exposure to air pollutants results in impairments of children's and adolescents' lung function, with the most pronounced effects observed three-to-four days post-exposure. This delayed impact suggests a prolonged risk of respiratory impairment following exposure, but further work is required to fully elucidate the timeline and associated dose-response relationship. The limited evidence available suggests that physical activity levels may be lower during periods with high air pollution concentrations, particularly in those living in urban areas or near roads. This is especially concerning for children with asthma, who are at a greater risk of experiencing poorer lung function due to the combined effects of reduced physical activity and increased pollutant concentrations. Physical activity during periods of high air pollution concentrations is tentatively suggested to deleteriously influence lung function in children and adolescents. CI - (c) 2025. The Author(s). FAU - Gudziunaite, Samanta AU - Gudziunaite S AD - Applied Sports, Technology, Exercise and Medicine (A-STEM) Research Centre, Swansea University, Swansea, UK. FAU - Mackintosh, Kelly A AU - Mackintosh KA AD - Applied Sports, Technology, Exercise and Medicine (A-STEM) Research Centre, Swansea University, Swansea, UK. FAU - Davies, Gwyneth A AU - Davies GA AD - Swansea University Medical School, Swansea University, Swansea, UK. FAU - Jordan, Kathryn A AU - Jordan KA AD - Applied Sports, Technology, Exercise and Medicine (A-STEM) Research Centre, Swansea University, Swansea, UK. FAU - Lewis, Paul D AU - Lewis PD AD - Swansea University School of Management, Swansea, UK. FAU - Griffiths, Chris J AU - Griffiths CJ AD - Wolfson Institute, Queen Mary University of London, London, UK. FAU - Alexander Swain, T AU - Alexander Swain T AD - Applied Sports, Technology, Exercise and Medicine (A-STEM) Research Centre, Swansea University, Swansea, UK. FAU - McNarry, Melitta A AU - McNarry MA AUID- ORCID: 0000-0003-0813-7477 AD - Applied Sports, Technology, Exercise and Medicine (A-STEM) Research Centre, Swansea University, Swansea, UK. m.mcnarry@swansea.ac.uk. LA - eng GR - [AUK-AC-2012-01/Asthma UK Centre for Applied Research/ GR - AUK-AC-2018-01]/Asthma UK Centre for Applied Research/ PT - Journal Article PT - Systematic Review DEP - 20250521 PL - Switzerland TA - Sports Med Open JT - Sports medicine - open JID - 101662568 PMC - PMC12095106 OTO - NOTNLM OT - Adolescents OT - Air quality OT - Children OT - Environmental exposures OT - Health outcomes OT - Paediatrics COIS- Declarations. Ethics Approval and Consent to Participate: Not applicable. Consent for Publication: Not applicable. Competing Interests: Samanta Gudziunaite, Kelly Mackintosh, Gwyneth Davies, Kathryn Jordan, Paul Lewis, Chris Griffiths, T. Alexander Swain, and Melitta McNarry declare that they have no competing interests with the content of this article. EDAT- 2025/05/22 00:28 MHDA- 2025/05/22 00:29 PMCR- 2025/05/21 CRDT- 2025/05/21 23:28 PHST- 2023/10/17 00:00 [received] PHST- 2025/04/22 00:00 [accepted] PHST- 2025/05/22 00:29 [medline] PHST- 2025/05/22 00:28 [pubmed] PHST- 2025/05/21 23:28 [entrez] PHST- 2025/05/21 00:00 [pmc-release] AID - 10.1186/s40798-025-00856-3 [pii] AID - 856 [pii] AID - 10.1186/s40798-025-00856-3 [doi] PST - epublish SO - Sports Med Open. 2025 May 21;11(1):57. doi: 10.1186/s40798-025-00856-3. PMID- 40398529 OWN - NLM STAT- MEDLINE DCOM- 20251204 LR - 20260520 IS - 1532-821X (Electronic) IS - 0003-9993 (Linking) VI - 106 IP - 12 DP - 2025 Dec TI - Psychometric Properties of Free-Living Step-Based Metrics (Daily Steps and Peak Cadence) in Multiple Sclerosis. PG - 1837-1843 LID - S0003-9993(25)00708-7 [pii] LID - 10.1016/j.apmr.2025.05.005 [doi] AB - OBJECTIVE: We examined the reliability, precision, and clinically detectable change of step-based metrics (daily steps, peak 30-min cadence [Peak-30(CAD)], and peak 1-min cadence [Peak-1(CAD)]) over 6 months in the absence of intervention and evaluated the construct validity through correlations with laboratory-assessed walking and gait performance among persons with multiple sclerosis (MS). DESIGN: Cross-sectional study. SETTING: University-based laboratory. PARTICIPANTS: Seventy-eight ambulatory adults (18-64y) with MS. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Free-living physical activity (via ActiGraph GT3X accelerometer), the Timed 25-Foot Walk, 6-minute walk, gait assessment (gait velocity, step length, and time), and disability status (the 12-item MS Walking Scale, Patient-Determined Disease Steps, and Self-Report Expanded Disability Status Scale) were measured before and after 6 months without any intervention. RESULTS: Step-based metrics were stable with no significant changes across time (P>.05) and demonstrated good test-retest reliability (intraclass correlation coefficients: 0.80-0.85) and acceptable precision (SEM%s:14.4% approximately 24.3%). The minimal detectable changes at 95% CIs (MDC(95)) values for Peak-30(CAD), Peak-1(CAD), and daily steps were 25.6 steps/min, 31.0 steps/min, and 2909.2 steps/d, respectively. There were consistent, strong associations between peak cadence with walking tests, gait parameters, and disability status at both time points (|r(s)|=.52-.79), even after controlling for daily steps (|pr(s)|=.25-.58; P<.05). CONCLUSIONS: Walking represents an important clinical endpoint in people with MS, yet it is often measured in controlled settings using performance-based tests that might not reflect real-world status. Our findings support step-based metrics via accelerometry as reliable and valid measures of free-living ambulatory performance and may inform the inclusion of these metrics in clinical trials among people with MS. CI - Copyright (c) 2025 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Zheng, Peixuan AU - Zheng P AD - Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA. Electronic address: pxzheng@uic.edu. FAU - Motl, Robert W AU - Motl RW AD - Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250519 PL - United States TA - Arch Phys Med Rehabil JT - Archives of physical medicine and rehabilitation JID - 2985158R SB - IM MH - Humans MH - Adult MH - Male MH - Female MH - *Multiple Sclerosis/physiopathology/rehabilitation/psychology MH - Middle Aged MH - Cross-Sectional Studies MH - Reproducibility of Results MH - Psychometrics MH - Disability Evaluation MH - *Walking/physiology MH - Young Adult MH - Adolescent MH - Accelerometry MH - Walk Test MH - Gait/physiology OTO - NOTNLM OT - Accelerometry OT - Cadence OT - Clinical change OT - Multiple sclerosis OT - Precision OT - Rehabilitation OT - Reliability OT - Validity OT - Walking EDAT- 2025/05/22 00:28 MHDA- 2025/12/05 01:02 CRDT- 2025/05/21 19:32 PHST- 2024/09/13 00:00 [received] PHST- 2025/03/24 00:00 [revised] PHST- 2025/05/13 00:00 [accepted] PHST- 2025/12/05 01:02 [medline] PHST- 2025/05/22 00:28 [pubmed] PHST- 2025/05/21 19:32 [entrez] AID - S0003-9993(25)00708-7 [pii] AID - 10.1016/j.apmr.2025.05.005 [doi] PST - ppublish SO - Arch Phys Med Rehabil. 2025 Dec;106(12):1837-1843. doi: 10.1016/j.apmr.2025.05.005. Epub 2025 May 19. PMID- 40397146 OWN - NLM STAT- MEDLINE DCOM- 20250820 LR - 20261010 IS - 1432-0932 (Electronic) IS - 0940-6719 (Linking) VI - 34 IP - 7 DP - 2025 Jul TI - Identifying and validating prognostic parameters to predict curve progression in adolescents with idiopathic scoliosis. PG - 2653-2661 LID - 10.1007/s00586-025-08922-w [doi] AB - PURPOSE: This study aimed to identify and validate prognostic factors to predict scoliosis progression. METHODS: One hundred sixty-two girls, aged 13.5 +/- 1.7 years old, diagnosed with idiopathic scoliosis were recruited. One hundred were used for model development, and 62 for testing, in which the number of progression cases was 25 and 11, respectively. All participants were scanned by an ultrasound (US) system for two consecutive visits (baseline and follow-up). The baseline parameters included (a) demographic: age, body mass index (BMI), and menarche status; (b) radiographic: X-ray Cobb angle, number-of-curve (NOC), and Risser sign; (c) ultrasonic: US Cobb, maximum axial vertebral rotation (AVR), Cobb angle at the plane of maximum curvature (PMC), kyphotic angle (KA) and reflection coefficient (RC) index. For the follow-up visit, only the US Cobb was recorded. The demographic and X-ray parameters were extracted from the scoliosis clinical records. The US parameters were measured by trained raters with good measurement reliability. The prediction model was developed using logistic regression analysis. RESULTS: The final predictors were US Cobb change, RC index, and NOC, and the probability of curve progression risk was Log (p/1-p) = -1.40 + 0.28(US Cobb change)-39.45(RC) + 1.36 (NOC). The model achieved sensitivity, specificity, and accuracy of 90% on the 62 test dataset, which was much better than using US Cobb change only. CONCLUSIONS: The results indicated that participants with lower RC (weaker bone, RC /= 5 degrees ), and multiple curvatures (NOC > 1) were at a higher risk of curve progression. A large study including more progression cases is needed for further validation. CI - (c) 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Khodaei, Mahdieh AU - Khodaei M AD - University of Alberta, Edmonton, Canada. FAU - Parent, Eric C AU - Parent EC AD - University of Alberta, Edmonton, Canada. FAU - Le, Lawrence H AU - Le LH AD - University of Alberta, Edmonton, Canada. FAU - Stampe, Kyle AU - Stampe K AD - University of Alberta, Edmonton, Canada. FAU - Southon Hryniuk, Sarah AU - Southon Hryniuk S AD - Alberta Health Services, Edmonton, Canada. FAU - Lou, Edmond AU - Lou E AD - University of Alberta, Edmonton, Canada. elou@ualberta.ca. LA - eng GR - RES0038364/Scoliosis Research Society/ PT - Journal Article PT - Validation Study DEP - 20250521 PL - Germany TA - Eur Spine J JT - European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society JID - 9301980 SB - IM MH - Humans MH - *Scoliosis/diagnostic imaging/diagnosis MH - Female MH - *Disease Progression MH - Adolescent MH - Prognosis MH - Child MH - Ultrasonography MH - Radiography MH - Reproducibility of Results OTO - NOTNLM OT - Cobb change OT - Prediction model OT - Reflection coefficient OT - Scoliosis OT - Ultrasound OT - Validation COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/05/21 12:31 MHDA- 2025/08/31 19:58 CRDT- 2025/05/21 11:15 PHST- 2025/02/22 00:00 [received] PHST- 2025/05/04 00:00 [accepted] PHST- 2025/04/28 00:00 [revised] PHST- 2025/08/31 19:58 [medline] PHST- 2025/05/21 12:31 [pubmed] PHST- 2025/05/21 11:15 [entrez] AID - 10.1007/s00586-025-08922-w [pii] AID - 10.1007/s00586-025-08922-w [doi] PST - ppublish SO - Eur Spine J. 2025 Jul;34(7):2653-2661. doi: 10.1007/s00586-025-08922-w. Epub 2025 May 21. PMID- 40396059 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250522 IS - 2249-4863 (Print) IS - 2278-7135 (Electronic) IS - 2249-4863 (Linking) VI - 14 IP - 4 DP - 2025 Apr TI - Unveiling depression-A cross-sectional study of college students in Amritsar District. PG - 1245-1251 LID - 10.4103/jfmpc.jfmpc_1336_24 [doi] AB - BACKGROUND: Mental health problems are becoming more and more frequently a burden on modern societies. A gradually evolving way of life, particularly in westernizing nations like India, could be attributed to a variety of causes, including shifting societal support, partnerships, and family bonding. Young People having conflicts with parents and friends, academic pressure and getting inconsistent sleep, and being in an environment where alcohol and drugs are more readily available could all be risk factors for depression. OBJECTIVES: 1. To determine the prevalence of depressive symptoms among professional and non-professional course students. 2. To assess the factors associated with depressive symptoms in these students. MATERIAL AND METHODS: This cross-sectional study was conducted from 1 January 2014 to 31 December 2014 in Amritsar district among 1470 students of various educational institutes. After IEC approval, the study was carried out after obtaining written consent from students aged 18 to 24 years. They were interviewed using a pre-validated, semi-structured questionnaire that included Depression Factors Questionnaire, Socio-demographic section and the Patient Health Questionnaire-9 (PHQ-9). Statistical analysis was performed using Chi-square tests. RESULTS: Majority (82.9%) were from non-professional degree courses. Nearly half of the study population i.e. 761 (51.8%) belonged to Hindu religion. Depression was among the highest among overweight (25%) as compared to normal and underweight students. Depression was also observed to be higher among those respondents who became anxious on getting a new assignment (24.7%) as compared to those who could do the assignment on time (12.7%). CONCLUSION: Students who had good friends and satisfactory relationships with their parents and neighbors experienced lower levels of depression compared to those who did not. CI - Copyright: (c) 2025 Journal of Family Medicine and Primary Care. FAU - Kaur, Shalinder AU - Kaur S AD - Department of Community Medicine, GMC and RH, Patiala, Punjab, India. FAU - Oberoi, Simmi AU - Oberoi S AD - Department of Community Medicine, GMC and RH, Patiala, Punjab, India. FAU - Batish, Rohit AU - Batish R AD - Department of Community Medicine, GMC and RH, Patiala, Punjab, India. FAU - Deepti, Shyam Sunder AU - Deepti SS AD - Department of Community Medicine, GMC, Amritsar, Punjab, India. FAU - Lal, Mohan AU - Lal M AD - Department of Community Medicine, GMC, Amritsar, Punjab, India. FAU - Kaur, Balpreet AU - Kaur B AD - Department of Community Medicine, GMC and RH, Patiala, Punjab, India. LA - eng PT - Journal Article DEP - 20250425 PL - India TA - J Family Med Prim Care JT - Journal of family medicine and primary care JID - 101610082 PMC - PMC12088583 OTO - NOTNLM OT - Depression OT - mental health OT - psychological conflicts OT - youth COIS- There are no conflicts of interest. EDAT- 2025/05/21 06:26 MHDA- 2025/05/21 06:27 PMCR- 2025/04/01 CRDT- 2025/05/21 04:45 PHST- 2024/08/03 00:00 [received] PHST- 2024/10/11 00:00 [revised] PHST- 2024/10/15 00:00 [accepted] PHST- 2025/05/21 06:27 [medline] PHST- 2025/05/21 06:26 [pubmed] PHST- 2025/05/21 04:45 [entrez] PHST- 2025/04/01 00:00 [pmc-release] AID - JFMPC-14-1245 [pii] AID - 10.4103/jfmpc.jfmpc_1336_24 [doi] PST - ppublish SO - J Family Med Prim Care. 2025 Apr;14(4):1245-1251. doi: 10.4103/jfmpc.jfmpc_1336_24. Epub 2025 Apr 25. PMID- 40395104 OWN - NLM STAT- MEDLINE DCOM- 20250809 LR - 20260512 IS - 1552-485X (Electronic) IS - 1552-4841 (Linking) VI - 198 IP - 6 DP - 2025 Sep TI - A Randomized Double-Blind Placebo-Controlled Trial of Guanfacine Extended Release for Aggression and Self-Injurious Behavior Associated With Prader-Willi Syndrome. PG - 62-70 LID - 10.1002/ajmg.b.33032 [doi] AB - Prader-Willi Syndrome (PWS), a rare genetic disorder, affects development and behavior, frequently resulting in self-injury, aggression, hyperphagia, oppositional behavior, impulsivity, and over-activity, causing significant morbidity. Currently, limited therapeutic options are available to manage these neuropsychiatric manifestations. A randomized, placebo-controlled trial was conducted to assess the efficacy of guanfacine-extended release (GXR) in reducing aggression and self-injury in individuals with PWS. Subjects with a diagnosis of PWS, aged 6-35 years with moderate to severe aggressive and/or self-injurious behavior, as determined by the clinical global impression (CGI)-Severity scale, were included in an 8-week double-blind, placebo-controlled, fixed-flexible dose clinical trial of GXR, that was followed by an 8-week open-label extension phase. Validated behavioral instruments and physician assessments measured the efficacy of GXR treatment, its safety, and tolerability. GXR was effective in reducing aggression/agitation and hyperactivity/noncompliance, as measured by the Aberrant Behavior Checklist (ABC) scales (p = 0.03). Overall aberrant behavior scores significantly reduced in the GXR arm. Aggression, as measured by the modified overt aggression scale (MOAS) also showed a significant reduction. Skin-picking lesions, as measured by the self injury trauma (SIT) scale, decreased in response to GXR. No serious adverse events were experienced by any of the study participants. Fatigue/sedation was the only adverse event significantly associated with GXR. The GXR group demonstrated significant overall clinical improvement, as measured by the CGI-Improvement (CGI-I) scale (p < 0.01). Findings of this pragmatic trial strongly support the use of GXR for the treatment of aggression, skin picking, and hyperactivity in children, adolescents, and adults with PWS. CI - (c) 2025 Wiley Periodicals LLC. FAU - Singh, Deepan AU - Singh D AUID- ORCID: 0000-0002-1857-944X AD - Department of Psychiatry, Maimonides Medical Center, Brooklyn, New York, USA. FAU - Silver, Michael AU - Silver M AD - Research Administration, Maimonides Medical Center, Brooklyn, New York, USA. FAU - Jacob, Theresa AU - Jacob T AD - Department of Psychiatry, Maimonides Medical Center, Brooklyn, New York, USA. AD - Clinical and Translational Research Labs, Maimonides Medical Center, Brooklyn, New York, USA. LA - eng GR - Foundation for Prader-Willi Research/ GR - Maimonides Research and Development Foundation/ PT - Journal Article PT - Pragmatic Clinical Trial PT - Randomized Controlled Trial DEP - 20250521 PL - United States TA - Am J Med Genet B Neuropsychiatr Genet JT - American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics JID - 101235742 RN - 30OMY4G3MK (Guanfacine) RN - 0 (Delayed-Action Preparations) SB - IM MH - Humans MH - *Prader-Willi Syndrome/drug therapy/complications/psychology MH - *Self-Injurious Behavior/drug therapy MH - Adolescent MH - Female MH - Male MH - Double-Blind Method MH - Child MH - *Aggression/drug effects MH - Adult MH - *Guanfacine/therapeutic use/administration & dosage/adverse effects MH - Young Adult MH - Delayed-Action Preparations MH - Treatment Outcome OTO - NOTNLM OT - Prader-Willi syndrome OT - aggression OT - hyperactivity OT - irritability OT - skin-picking EDAT- 2025/05/21 06:26 MHDA- 2025/08/09 13:48 CRDT- 2025/05/21 03:33 PHST- 2025/04/10 00:00 [revised] PHST- 2025/01/24 00:00 [received] PHST- 2025/04/25 00:00 [accepted] PHST- 2025/08/09 13:48 [medline] PHST- 2025/05/21 06:26 [pubmed] PHST- 2025/05/21 03:33 [entrez] AID - 10.1002/ajmg.b.33032 [doi] PST - ppublish SO - Am J Med Genet B Neuropsychiatr Genet. 2025 Sep;198(6):62-70. doi: 10.1002/ajmg.b.33032. Epub 2025 May 21. PMID- 40394751 OWN - NLM STAT- MEDLINE DCOM- 20250521 LR - 20251122 IS - 2040-1752 (Electronic) IS - 2040-1744 (Print) IS - 2040-1744 (Linking) VI - 16 DP - 2025 May 21 TI - Associations of placental lncRNA expression with maternal pre-pregnancy BMI and infant birthweight in two birth cohorts. PG - e20 LID - 10.1017/S204017442500011X [doi] AB - Pre-pregnancy obesity (ppOB) is linked to pregnancy complications and abnormal fetal growth through placental mechanisms, and long non-coding RNAs (lncRNAs) may play an epigenetic role in these processes. We investigated overall and sex-specific associations of pre-pregnancy body mass index (ppBMI), ppOB, and birthweight with placental lncRNA transcripts in two birth cohorts. Study participants were mother-child dyads recruited to the CANDLE (Memphis, TN)(n = 725) and GAPPS (Seattle and Yakima, WA)(n = 159) cohorts. Maternal ppBMI was assessed at enrollment using interviewer-administered questionnaires. LncRNAs (1,077 and 1,033 for CANDLE and GAPPS, respectively) were sequenced from placental samples collected at birth. Placental lncRNA was regressed on ppBMI, ppOB (ppBMI >/=30kg/m(2)), or continuous birthweight in cohort-specific weighted linear models controlling for a priori-specified confounders and experimental variables. Potential effect modification by infant-sex was examined in sex-stratified analyses and models including BMI-infant-sex interaction terms. No lncRNA transcripts were significantly associated with ppBMI, ppOB, or birthweight in primary models. Among male infants in CANDLE, expression of three lncRNA transcripts (ERVH48-1, AC139099.1, CEBPA-DT) was associated with ppBMI and one transcript (AC104083.1) with birthweight. In GAPPS, ppBMI was associated with two lncRNA transcripts (AP000879.1 and AL365203.2) among males, and birthweight was associated with 17 lncRNA transcripts (including LINC02709, KANSL1-AS1, DANCR, EPB41L4A-AS1, and GABPB1-AS1) among females. No BMI-infant-sex interactions were observed. Though many of these potential associations are for uncharacterized transcripts, several identified lncRNAs (e.g., ERVH48-1 and CEBPA-DT) have been linked to pathways controlling cancer or placental growth, trophoblast differentiation, and gene expression. These associations warrant validation in future studies. FAU - Hussey, Michael R AU - Hussey MR AUID- ORCID: 0000-0003-4234-0030 AD - Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA. FAU - MacDonald, James AU - MacDonald J AD - Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA. FAU - Bammler, Theo K AU - Bammler TK AD - Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA. FAU - Tekola-Ayele, Fasil AU - Tekola-Ayele F AD - Epidemiology Branch, Division of Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. FAU - Kerr, Kathleen F AU - Kerr KF AD - Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA. FAU - Paquette, Alison G AU - Paquette AG AD - Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA. AD - Department of Pediatrics, School of Medicine, University of Washington, Seattle, WA, USA. AD - Seattle Children's Research Institute, Seattle, WA, USA. FAU - Marsit, Carmen J AU - Marsit CJ AUID- ORCID: 0000-0003-4566-150X AD - Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. FAU - LeWinn, Kaja Z AU - LeWinn KZ AD - Department of Psychiatry and Behavioral Sciences, School of Medicine, University of California, San Francisco, CA, USA. FAU - Zhao, Qi AU - Zhao Q AD - Department of Preventative Medicine, University of Tennessee Health Science Center, Memphis, TN, USA. FAU - Karr, Catherine J AU - Karr CJ AD - Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA. AD - Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA. AD - Department of Pediatrics, School of Medicine, University of Washington, Seattle, WA, USA. FAU - Sathyanarayana, Sheela AU - Sathyanarayana S AD - Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA. AD - Department of Pediatrics, School of Medicine, University of Washington, Seattle, WA, USA. AD - Seattle Children's Research Institute, Seattle, WA, USA. FAU - Enquobahrie, Daniel A AU - Enquobahrie DA AD - Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA. AD - Department of Health Systems and Population Health, School of Public Health, University of Washington, Seattle, WA, USA. LA - eng GR - R56 ES026528/ES/NIEHS NIH HHS/United States GR - UH3 OD023271/OD/NIH HHS/United States GR - P30 ES007033/ES/NIEHS NIH HHS/United States GR - K99 HD096112/HD/NICHD NIH HHS/United States GR - R00 HD096112/HD/NICHD NIH HHS/United States GR - R01 ES025888/ES/NIEHS NIH HHS/United States GR - UG3 OD023271/OD/NIH HHS/United States GR - P01 AG055367/AG/NIA NIH HHS/United States GR - T32 ES015459/ES/NIEHS NIH HHS/United States GR - R01 ES023500/ES/NIEHS NIH HHS/United States PT - Journal Article DEP - 20250521 PL - England TA - J Dev Orig Health Dis JT - Journal of developmental origins of health and disease JID - 101517692 RN - 0 (RNA, Long Noncoding) SB - IM MH - Humans MH - Female MH - *RNA, Long Noncoding/genetics/metabolism MH - Pregnancy MH - *Body Mass Index MH - *Placenta/metabolism MH - Male MH - *Birth Weight/genetics MH - Adult MH - Infant, Newborn MH - Cohort Studies MH - Birth Cohort MH - *Obesity/genetics PMC - PMC12097519 MID - NIHMS2070865 OTO - NOTNLM OT - Long non-coding RNA OT - birthweight OT - placenta OT - pre-pregnancy obesity COIS- Conflicts of Interest: None EDAT- 2025/05/21 00:29 MHDA- 2025/05/21 18:29 PMCR- 2025/11/21 CRDT- 2025/05/20 23:52 PHST- 2025/05/21 18:29 [medline] PHST- 2025/05/21 00:29 [pubmed] PHST- 2025/05/20 23:52 [entrez] PHST- 2025/11/21 00:00 [pmc-release] AID - S204017442500011X [pii] AID - 10.1017/S204017442500011X [doi] PST - epublish SO - J Dev Orig Health Dis. 2025 May 21;16:e20. doi: 10.1017/S204017442500011X. PMID- 40392587 OWN - NLM STAT- MEDLINE DCOM- 20250520 LR - 20260913 IS - 1438-8871 (Electronic) IS - 1439-4456 (Print) IS - 1438-8871 (Linking) VI - 27 DP - 2025 May 20 TI - Mobile- and Web-Based Interventions for Promoting Healthy Diets, Preventing Obesity, and Improving Health Behaviors in Children and Adolescents: Systematic Review of Randomized Controlled Trials. PG - e60602 LID - 10.2196/60602 [doi] LID - e60602 AB - BACKGROUND: Childhood and adolescent obesity is a growing global health issue linked to noncommunicable diseases such as cardiovascular disease and type 2 diabetes. Digital health technologies, including mobile apps and web-based programs, offer scalable tools to improve health behaviors, but their effectiveness in young populations remains unclear. OBJECTIVE: This systematic review aimed to evaluate the effectiveness of mobile and web-based digital interventions in promoting healthy diets, reducing obesity risk, increasing physical activity, and improving nutrition-related knowledge and attitudes among children and adolescents. METHODS: A systematic search was conducted across PubMed, Scopus, Web of Science, and Google Scholar databases, along with hand-searching reference lists of key systematic reviews. The search encompassed records published up to September 30, 2024. Eligible studies were randomized controlled trials targeting dietary intake, anthropometric measurements, physical activity, or nutrition-related attitudes and knowledge among participants aged 0.9), good results for foot width (ICC < 0.9), and poor to moderate results for all other measurements (ICC < 0.5, ICC < 0.75). Agreement results for hallux valgus were acceptable (within established reference) and the remaining variables were not acceptable (outside established reference). CONCLUSIONS: The majority of the manual assessment procedures were found to have poor reliability. This study highlights the need for reliable and time-efficient tools to assist clinicians in assessing manual clinical measurements and future research should explore this. LEVEL OF EVIDENCE: Level III. CI - (c) The Author(s) 2025. FAU - Saabye, Thea AU - Saabye T AD - Department of Orthopedic Surgery, University Hospital of Copenhagen, Rigshospitalet, Denmark. FAU - Colding-Rasmussen, Thomas AU - Colding-Rasmussen T AUID- ORCID: 0000-0003-3457-3715 AD - Department of Orthopedic Surgery, University Hospital of Copenhagen, Rigshospitalet, Denmark. FAU - Balslev-Clausen, Andreas AU - Balslev-Clausen A AUID- ORCID: 0009-0003-3884-3804 AD - Department of Orthopedic Surgery, University Hospital of Copenhagen, Rigshospitalet, Denmark. FAU - Bodtker, Soren AU - Bodtker S AD - Department of Orthopedic Surgery, University Hospital of Copenhagen, Rigshospitalet, Denmark. FAU - Wong, Christian AU - Wong C AUID- ORCID: 0000-0002-3201-5827 AD - Department of Orthopedic Surgery, University Hospital of Copenhagen, Rigshospitalet, Denmark. AD - Department of Orthopedic Surgery, University Hospital of Copenhagen, Hvidovre, Denmark. FAU - Harsted, Steen AU - Harsted S AUID- ORCID: 0000-0002-1879-2224 AD - Research Unit for Clinical Biomechanics, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. LA - eng PT - Journal Article DEP - 20250515 PL - England TA - J Child Orthop JT - Journal of children's orthopaedics JID - 101313582 PMC - PMC12081435 OTO - NOTNLM OT - pediatric lower extremity OT - reliability OT - reproducibility OT - stability OT - test-retest COIS- The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/05/19 12:30 MHDA- 2025/05/19 12:31 PMCR- 2025/05/15 CRDT- 2025/05/19 06:24 PHST- 2024/10/04 00:00 [received] PHST- 2025/02/06 00:00 [accepted] PHST- 2025/05/19 12:31 [medline] PHST- 2025/05/19 12:30 [pubmed] PHST- 2025/05/19 06:24 [entrez] PHST- 2025/05/15 00:00 [pmc-release] AID - 10.1177_18632521251322639 [pii] AID - 10.1177/18632521251322639 [doi] PST - epublish SO - J Child Orthop. 2025 May 15;19(3):189-198. doi: 10.1177/18632521251322639. eCollection 2025 Jun. PMID- 40384840 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250520 IS - 0970-0218 (Print) IS - 1998-3581 (Electronic) IS - 0970-0218 (Linking) VI - 50 IP - 2 DP - 2025 Mar-Apr TI - Household Food Security, Feeding Practices, and Anthropometric Failure Among Children Aged 6-23 Months: A Hospital-Based Study. PG - 331-336 LID - 10.4103/ijcm.ijcm_323_23 [doi] AB - BACKGROUND: Household food security (HHFS) and age-appropriate complementary feeding (CF) conceptually play an important role in growth of a child. This study aims to assess the status of HHFS, age-appropriate CF, and undernutrition among children of 6-23 months and their association (if any). MATERIALS AND METHODS: This institution-based cross-sectional study was conducted among children attending Pediatric OPD of College of Medicine and Sagore Dutta Hospital. Children were assessed regarding age-appropriate complementary feeding using infant and young child feeding (IYCF) practices indicator, nutritional status using composite index of anthropometric failure indicators, and HHFS using standardized and validated HHFS short Bengali version questionnaire. Mothers/primary caregivers were the respondents. Categorical variables were expressed in frequency and percentages. Statistical analysis was done in Jamovi (v2.2.5). RESULTS: 430 mother-child dyads participated in the study with 83.26% of them having low or very low food security. Minimum acceptable diet (MAD) was absent in 74.65% of children and 42.09% of children had single/multiple anthropometric failure(s). Children aged 6-8 months had higher odds of not having MAD (AOR = 3.6, 1.5-8.3). Male gender (AOR = 2.7, 1.7-4.2) and lack of MAD (AOR = 2.7, 1.6-4.7) were associated with anthropometric failure. However, HHFS was not found to be associated with either lack of MAD or anthropometric failure in this study population. CONCLUSION: Improper transition from exclusive breast feeding to CF may be responsible for higher odds of having lack of MAD in 6-8 months age group, which require strengthening of IEC activity related to IYCF practices on or before initiation of complementary feeding. CI - Copyright: (c) 2025 Indian Journal of Community Medicine. FAU - Chatterjee, Rohan AU - Chatterjee R AD - Department of Community Medicine, College of Medicine and Sagore Dutta Hospital, Kolkata, West Bengal, India. FAU - Ray, Soumalya AU - Ray S AD - Department of Community Medicine, College of Medicine and Sagore Dutta Hospital, Kolkata, West Bengal, India. FAU - Mukhopadhyay, Dipta Kanti AU - Mukhopadhyay DK AD - Department of Community Medicine, College of Medicine and Sagore Dutta Hospital, Kolkata, West Bengal, India. LA - eng PT - Journal Article DEP - 20250201 PL - India TA - Indian J Community Med JT - Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine JID - 9315574 PMC - PMC12080898 OTO - NOTNLM OT - Composite index of anthropometric failure OT - India OT - household food security OT - infant and young child feeding practices OT - minimum acceptable diet OT - undernutrition COIS- There are no conflicts of interest. EDAT- 2025/05/19 12:30 MHDA- 2025/05/19 12:31 PMCR- 2025/03/01 CRDT- 2025/05/19 06:05 PHST- 2023/05/22 00:00 [received] PHST- 2024/05/22 00:00 [accepted] PHST- 2025/05/19 12:31 [medline] PHST- 2025/05/19 12:30 [pubmed] PHST- 2025/05/19 06:05 [entrez] PHST- 2025/03/01 00:00 [pmc-release] AID - IJCM-50-331 [pii] AID - 10.4103/ijcm.ijcm_323_23 [doi] PST - ppublish SO - Indian J Community Med. 2025 Mar-Apr;50(2):331-336. doi: 10.4103/ijcm.ijcm_323_23. Epub 2025 Feb 1. PMID- 40383996 OWN - NLM STAT- MEDLINE DCOM- 20250519 LR - 20260624 IS - 1945-7243 (Electronic) IS - 0046-9580 (Print) IS - 0046-9580 (Linking) VI - 62 DP - 2025 Jan-Dec TI - Psychometric Evaluation of the Malay Version of Weight Stigma Exposure Inventory (WeSEI) Among Malaysian Young Adults. PG - 469580251339395 LID - 10.1177/00469580251339395 [doi] LID - 00469580251339395 AB - The present study translated the Weight Stigma Exposure Inventory (WeSEI), an instrument assessing observed weight stigma, into Malay, and evaluated its psychometric properties among Malaysian young adults. Young adults who were Malaysian university students provided their informed consent electronically and completed an online survey hosted on Google Forms. Data were collected by recruiting participants via emails or WhatsApp between March and August 2024. The mean age of the participants (N = 691; 26.0% males) was 21.3 years (SD = 2.42). The online survey included the Malay version of WeSEI and demographic information (ie, gender, height, and weight). Height and weight were used to calculate body mass index and classified into 2 weight status groups (higher weight or non-higher weight). Psychometric evaluations included confirmatory factor analysis (CFA), internal consistency, multigroup CFA across gender and weight status groups, and known-group validity between higher weight and non-higher weight groups. The CFA results supported the 7-factor structure for the WeSEI. All subscales of the WeSEI and the entire WeSEI had good internal consistency (omega > 0.85). Multigroup CFA results supported measurement invariance across gender (ie, males vs females) and weight status (ie, higher weight vs non-higher weight) groups. Also, known-group validity was supported because significantly higher WeSEI scores were observed among those in the higher weight group compared to those in the non-higher weight group. The WeSEI is a promising psychometric instrument that can assess observed weight stigma among Malaysian young adults. FAU - Ying Gan, Wan AU - Ying Gan W AUID- ORCID: 0000-0002-9016-3414 AD - Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia. FAU - Chen, I-Hua AU - Chen IH AD - Chinese Academy of Education Big Data, Qufu Normal University, China. FAU - Tung, Serene En Hui AU - Tung SEH AUID- ORCID: 0000-0001-9122-7523 AD - Division of Nutrition, Dietetics, and Food Science, School of Health Sciences, IMU University, Bukit Jalil, Kuala Lumpur, Malaysia. FAU - Huang, Ru-Yi AU - Huang RY AD - Division of Family Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan. AD - School of Medicine, Tzu Chi University, Hualien, Taiwan. AD - Data Science Degree Program, National Taiwan University and Academia Sinica, Taipei, Taiwan. FAU - Poon, Wai Chuen AU - Poon WC AUID- ORCID: 0000-0003-1258-3576 AD - Sunway Business School, Sunway University, Selangor, Malaysia. FAU - Siaw, Yan-Li AU - Siaw YL AUID- ORCID: 0000-0002-2815-4867 AD - Department of Educational Psychology and Counselling, Faculty of Education, Universiti Malaya, Kuala Lumpur, Malaysia. FAU - Li, Wenjia AU - Li W AD - International College, Kirk University, Bangkok, Thailand. FAU - Chen, Jung-Sheng AU - Chen JS AD - Department of Medical Research, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan. FAU - O'Brien, Kerry M AU - O'Brien KM AD - School of Social Sciences, Faculty of Arts, Monash University, Melbourne VIC, Australia. FAU - Griffiths, Mark D AU - Griffiths MD AD - International Gaming Research Unit, Psychology Department, Nottingham Trent University, Nottingham, UK. FAU - Lin, Chung-Ying AU - Lin CY AUID- ORCID: 0000-0002-2129-4242 AD - Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan. AD - School of Nursing, College of Nursing, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Biostatistics Consulting Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250518 PL - United States TA - Inquiry JT - Inquiry : a journal of medical care organization, provision and financing JID - 0171671 SB - IM EIN - Inquiry. 2026 Jan-Dec;63:469580261450809. doi: 10.1177/00469580261450809. PMID: 42339775 MH - Humans MH - Male MH - *Psychometrics MH - Female MH - Malaysia MH - Young Adult MH - Surveys and Questionnaires MH - *Social Stigma MH - Reproducibility of Results MH - Adult MH - Body Mass Index MH - Factor Analysis, Statistical MH - *Body Weight MH - Adolescent PMC - PMC12089710 OTO - NOTNLM OT - observed weight stigma OT - psychometrics OT - weight OT - weight bias OT - young adults COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/05/19 06:26 MHDA- 2025/05/19 06:27 PMCR- 2025/05/18 CRDT- 2025/05/19 02:43 PHST- 2025/05/19 06:27 [medline] PHST- 2025/05/19 06:26 [pubmed] PHST- 2025/05/19 02:43 [entrez] PHST- 2025/05/18 00:00 [pmc-release] AID - 10.1177_00469580251339395 [pii] AID - 10.1177/00469580251339395 [doi] PST - ppublish SO - Inquiry. 2025 Jan-Dec;62:469580251339395. doi: 10.1177/00469580251339395. Epub 2025 May 18. PMID- 40383982 OWN - NLM STAT- MEDLINE DCOM- 20250704 LR - 20250710 IS - 1475-2662 (Electronic) IS - 0007-1145 (Print) IS - 0007-1145 (Linking) VI - 133 IP - 9 DP - 2025 May 14 TI - Development of two short FFQ to assess diet quality in UK pre-school and primary school-aged children based on National Diet and Nutrition Survey data. PG - 1287-1296 LID - 10.1017/S0007114525103449 [doi] AB - Assessing children's diets is currently challenging and burdensome. Abbreviated FFQ have the potential to assess dietary patterns in a rapid and standardised manner. Using nationally representative UK dietary intake and biomarker data, we developed an abbreviated FFQ to calculate dietary quality scores for pre-school and primary school-aged children. UK National Diet and Nutrition Survey (2008-2016) weekly consumption frequencies of 129 food groups from 4-d diaries were cross-sectionally analysed using principal component analysis. A 129-item score was derived, alongside a 12-item score based on foods with the six highest and six lowest coefficients. Participants included 1069 pre-schoolers and 2565 primary schoolchildren. The first principal component explained 3.4 and 3.0 % of the variation in the original diet variables for pre-school and primary school groups, respectively, and described a prudent diet pattern. Prudent diet scores were characterised by greater consumption of fruit, vegetables and tap water and lower consumption of crisps, manufactured coated chicken/turkey products, purchased chips and soft drinks for both age groups. Correlations between the 129-item and 12-item scores were 0.86 and 0.84 for pre-school and primary school-aged children, respectively. Bland-Altman mean differences between the scores were 0.00 sd; 95 % limits of agreement were -1.05 to 1.05 and -1.10 to 1.10 sd for pre-school and primary school-aged children, respectively. Correlations between dietary scores and nutritional biomarkers showed only minor attenuation for the 12-item compared with the 129-item scores, illustrating acceptable congruence between prudent diet scores. The two 12-item FFQ offer user-friendly tools to measure dietary quality among UK children. FAU - Mason, Morgan AU - Mason M AUID- ORCID: 0009-0003-1933-0077 AD - NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. AD - School of Healthcare Enterprise and Innovation, Faculty of Medicine, University of Southampton, SouthamptonSO16 6YD, UK. FAU - Shaw, Sarah C AU - Shaw SC AD - NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. AD - MRC Lifecourse Epidemiology Centre, University of Southampton, University Hospital Southampton, SouthamptonSO16 6YD, UK. FAU - Baird, Janis AU - Baird J AD - NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. AD - MRC Lifecourse Epidemiology Centre, University of Southampton, University Hospital Southampton, SouthamptonSO16 6YD, UK. AD - NIHR Applied Research Collaboration Wessex, Southampton Science Park, Innovation Centre, 2 Venture Road, Chilworth, SouthamptonSO16 7NP, UK. FAU - Barrett, Millie AU - Barrett M AD - MRC Lifecourse Epidemiology Centre, University of Southampton, University Hospital Southampton, SouthamptonSO16 6YD, UK. AD - Centre for Food Policy, City St George's, University of London, Northampton Square, LondonEC1V 0HB, UK. FAU - Lovelock, Donna AU - Lovelock D AD - NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. AD - School of Healthcare Enterprise and Innovation, Faculty of Medicine, University of Southampton, SouthamptonSO16 6YD, UK. FAU - Woods-Townsend, Kathryn AU - Woods-Townsend K AD - NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. AD - School of Healthcare Enterprise and Innovation, Faculty of Medicine, University of Southampton, SouthamptonSO16 6YD, UK. FAU - Godfrey, Keith M AU - Godfrey KM AD - NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. AD - MRC Lifecourse Epidemiology Centre, University of Southampton, University Hospital Southampton, SouthamptonSO16 6YD, UK. FAU - Vogel, Christina A AU - Vogel CA AD - NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. AD - MRC Lifecourse Epidemiology Centre, University of Southampton, University Hospital Southampton, SouthamptonSO16 6YD, UK. AD - NIHR Applied Research Collaboration Wessex, Southampton Science Park, Innovation Centre, 2 Venture Road, Chilworth, SouthamptonSO16 7NP, UK. AD - Centre for Food Policy, City St George's, University of London, Northampton Square, LondonEC1V 0HB, UK. FAU - Crozier, Sarah R AU - Crozier SR AD - NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. AD - MRC Lifecourse Epidemiology Centre, University of Southampton, University Hospital Southampton, SouthamptonSO16 6YD, UK. AD - NIHR Applied Research Collaboration Wessex, Southampton Science Park, Innovation Centre, 2 Venture Road, Chilworth, SouthamptonSO16 7NP, UK. LA - eng GR - U24 AG047867/AG/NIA NIH HHS/United States PT - Journal Article DEP - 20250519 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM MH - Humans MH - United Kingdom MH - Child MH - Female MH - Male MH - *Nutrition Surveys MH - *Diet/standards MH - Child, Preschool MH - Cross-Sectional Studies MH - Diet Records MH - Schools MH - *Diet, Healthy MH - Nutrition Assessment MH - Surveys and Questionnaires MH - Feeding Behavior PMC - PMC12229983 OTO - NOTNLM OT - Diet quality OT - Dietary assessment OT - FFQ OT - Principal component analysis OT - Young children EDAT- 2025/05/19 06:26 MHDA- 2025/07/04 06:27 PMCR- 2025/07/07 CRDT- 2025/05/19 02:32 PHST- 2025/07/04 06:27 [medline] PHST- 2025/05/19 06:26 [pubmed] PHST- 2025/05/19 02:32 [entrez] PHST- 2025/07/07 00:00 [pmc-release] AID - S0007114525103449 [pii] AID - 10.1017/S0007114525103449 [doi] PST - ppublish SO - Br J Nutr. 2025 May 14;133(9):1287-1296. doi: 10.1017/S0007114525103449. Epub 2025 May 19. PMID- 40383735 OWN - NLM STAT- MEDLINE DCOM- 20250704 LR - 20250707 IS - 1618-2650 (Electronic) IS - 1618-2642 (Print) IS - 1618-2642 (Linking) VI - 417 IP - 17 DP - 2025 Jul TI - Proposed RP-HPTLC-FLD kit for analysis of vitamin A palmitate in edible oils. PG - 3791-3801 LID - 10.1007/s00216-025-05894-0 [doi] AB - Preschool-aged children and non-pregnant women of reproductive age particularly in countries of a lower socio-demographic index may experience insufficient dietary vitamin A. Fortifying staple foods such as edible oils with vitamin A is a useful approach to reduce malnutrition. To enable better quality oil fortification, producers need reliable and inexpensive tools for assessment of the vitamin A contents of their products. A simple reversed-phase high-performance thin-layer chromatography fluorescence detection (RP-HPTLC-FLD) method was developed and studied for the quantification of vitamin A palmitate (VAP) in five edible plant oils. The challenging matrices of non-refined palm kernel oil and soybean oil, which are known to interfere with the accuracy of some easy-to-use test kits, were separated from VAP using the new RP-HPTLC-FLD method. The standard addition method provided good accuracy and acceptable calibration curves (coefficients of determination R(2) between 0.9874 and 0.9999) even for manual application. The developed RP-HPTLC-FLD method proved simple, robust, sustainable, cost-efficient, and suitable for low-tech (minimum equipment) on-site analysis. CI - (c) 2025. The Author(s). FAU - Meyer, Daniel AU - Meyer D AUID- ORCID: 0000-0002-1505-9529 AD - Institute of Nutritional Science, Chair of Food Science, Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392, Giessen, Germany. FAU - Hornlein, Sophia AU - Hornlein S AD - Institute of Nutritional Science, Chair of Food Science, Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392, Giessen, Germany. FAU - Rein, Dietrich AU - Rein D AUID- ORCID: 0000-0003-0076-1865 AD - BASF SE, Carl-Bosch-Str. 38, 67056, Ludwigshafen, Germany. FAU - Morlock, Gertrud E AU - Morlock GE AUID- ORCID: 0000-0001-9406-0351 AD - Institute of Nutritional Science, Chair of Food Science, Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392, Giessen, Germany. Gertrud.Morlock@uni-giessen.de. LA - eng GR - INST 162/536-1 FUGG/Deutsche Forschungsgemeinschaft/ GR - INST 162/471-1 FUGG/Deutsche Forschungsgemeinschaft/ PT - Journal Article DEP - 20250519 PL - Germany TA - Anal Bioanal Chem JT - Analytical and bioanalytical chemistry JID - 101134327 RN - 0 (Plant Oils) RN - 11103-57-4 (Vitamin A) RN - 0 (Retinyl Esters) RN - 1D1K0N0VVC (retinol palmitate) RN - 0 (Diterpenes) RN - 5QUO05548Z (Palm Oil) SB - IM MH - *Plant Oils/chemistry MH - *Vitamin A/analogs & derivatives/analysis MH - Chromatography, Thin Layer/methods MH - Retinyl Esters MH - Humans MH - *Chromatography, Reverse-Phase/methods MH - Diterpenes MH - Chromatography, High Pressure Liquid/methods MH - Limit of Detection MH - Palm Oil/chemistry MH - Food Analysis/methods MH - Reproducibility of Results PMC - PMC12227463 OTO - NOTNLM OT - Edible oil OT - Food fortification OT - High-performance thin-layer chromatography OT - Retinyl palmitate OT - Sustainability OT - Vitamin A quantification COIS- Declarations. Compliance with ethical standards: The authors declare compliance with ethical standards. Conflict of interest: The authors declare that they have no conflict of interest. The authors DM, SH, and GEM were at the time of study execution employees of Justus Liebig University Giessen, and DR of BASF SE. EDAT- 2025/05/19 00:37 MHDA- 2025/07/04 12:43 PMCR- 2025/05/19 CRDT- 2025/05/18 23:04 PHST- 2025/02/08 00:00 [received] PHST- 2025/04/23 00:00 [accepted] PHST- 2025/04/16 00:00 [revised] PHST- 2025/07/04 12:43 [medline] PHST- 2025/05/19 00:37 [pubmed] PHST- 2025/05/18 23:04 [entrez] PHST- 2025/05/19 00:00 [pmc-release] AID - 10.1007/s00216-025-05894-0 [pii] AID - 5894 [pii] AID - 10.1007/s00216-025-05894-0 [doi] PST - ppublish SO - Anal Bioanal Chem. 2025 Jul;417(17):3791-3801. doi: 10.1007/s00216-025-05894-0. Epub 2025 May 19. PMID- 40382692 OWN - NLM STAT- MEDLINE DCOM- 20250518 LR - 20260610 IS - 1735-3947 (Electronic) IS - 1029-2977 (Print) IS - 1029-2977 (Linking) VI - 28 IP - 4 DP - 2025 Apr 1 TI - Health Services Delivery by Non-physicians and Associated Factors in Iran: A Cross-sectional Study in 2023. PG - 207-216 LID - 10.34172/aim.31947 [doi] AB - BACKGROUND: The increasing demand for healthcare services and some associated factors including lack of physicians, lack of trust in physicians, ineffectiveness of treatments and high costs may be have led to a rise in non-physician-provided services. This study aims to assess health services delivery by non-physicians and its associated factors in Iran. METHODS: This study was a cross-sectional study conducted using a convenience sampling method in the Iranian community in 2023. A standard questionnaire with 45 questions was developed based on focus group discussions and a validation process to assess the status of receiving services in six medical areas including traditional medicine, abortion, traditional dentistry, obesity and slimming diets, bone setting, and addiction treatment. Data collection was carried out using online questionnaires on Iranian and non-Iranian social media platforms. Descriptive and analytical statistics were used to analyze the data, with logistic regression adjusting for various demographic factors. RESULTS: Out of 1713 participants, 53.9% (95% CI: 51.5%-56.3%) were women, and the majority were in the 30-40 age group. Traditional Islamic medicine was the most commonly sought service, with 56% (95% CI: 51.2%-60.8%) of users receiving it from non-physicians. Satisfaction with non-physician services varied, with 32.1% (95% CI: 25.8%-38.4%) reporting high satisfaction for traditional medicine, but only 49.4% (95% CI: 40.5%-58.3%) for experimental dentistry. Key reasons for choosing non-physician providers included the effectiveness of traditional treatments and fear of modern medicine's side effects. CONCLUSION: The result showed that the use of non-physician services can be considerable and that necessary interventions should be designed to standardize treatments and deal with substandard providers who may be harmful to the health of the community. CI - (c) 2025 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. FAU - Mehri, Ahmad AU - Mehri A AUID- ORCID: 0000-0001-7785-8441 AD - Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Hashemi Nazari, Seyed Saeed AU - Hashemi Nazari SS AUID- ORCID: 0000-0002-0883-3408 AD - Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran. FAU - Mostafavi, Farideh AU - Mostafavi F AD - Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Rostami Varnousfaderani, Mehran AU - Rostami Varnousfaderani M AD - Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Mahdavi, Seyed Amirhosein AU - Mahdavi SA AD - Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran. FAU - Haj-Manouchehri, Reza AU - Haj-Manouchehri R AD - Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran. FAU - Mirotorabi, Seyed Davood AU - Mirotorabi SD AD - Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran. FAU - Saberi Isfeedvajani, Mohsen AU - Saberi Isfeedvajani M AUID- ORCID: 0000-0002-3455-7013 AD - Spiritual Health Research Center, Life Style Institute & Department of Community Medicine, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran. LA - eng PT - Journal Article DEP - 20250401 PL - Iran TA - Arch Iran Med JT - Archives of Iranian medicine JID - 100889644 SB - IM MH - Humans MH - Iran MH - Cross-Sectional Studies MH - Female MH - Adult MH - Male MH - Middle Aged MH - Surveys and Questionnaires MH - *Delivery of Health Care/statistics & numerical data MH - Young Adult MH - Medicine, Traditional/statistics & numerical data MH - Adolescent PMC - PMC12085797 OTO - NOTNLM OT - Healthcare services OT - Non-physician providers OT - Patient satisfaction OT - Traditional medicine COIS- Competing Interests The authors declare that they have no conflicts of interest, financial relationships, or affiliations that could be perceived as influencing the research. EDAT- 2025/05/18 17:01 MHDA- 2025/05/18 18:23 PMCR- 2025/04/01 CRDT- 2025/05/18 05:42 PHST- 2024/08/30 00:00 [received] PHST- 2025/02/22 00:00 [accepted] PHST- 2025/05/18 18:23 [medline] PHST- 2025/05/18 17:01 [pubmed] PHST- 2025/05/18 05:42 [entrez] PHST- 2025/04/01 00:00 [pmc-release] AID - 10.34172/aim.31947 [doi] PST - ppublish SO - Arch Iran Med. 2025 Apr 1;28(4):207-216. doi: 10.34172/aim.31947. Epub 2025 Apr 1. PMID- 40380181 OWN - NLM STAT- MEDLINE DCOM- 20250517 LR - 20260624 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 25 IP - 1 DP - 2025 May 16 TI - Applicability of multiple quantitative ultrasound liver biomarkers in children and adolescents with severe obesity. PG - 390 LID - 10.1186/s12887-025-05750-1 [doi] LID - 390 AB - BACKGROUND: Obesity is associated with chronic liver disease, which is why improved non-invasive diagnostic assessment of liver affection is desirable. The ultrasound-based biomarkers Attenuation Imaging coefficient (ATI), Shear Wave Elastography (SWE), and Shear Wave Dispersion (SWD) have the potential to assess liver steatosis, fibrosis and inflammation/oedema respectively. The aim was therefore to evaluate the feasibility of applying ultrasound-based liver biomarkers in children and adolescents with severe obesity. METHODS: Ultrasound was performed, before treatment, in 56 patients with childhood obesity (< 18 years) referred for bariatric surgery or treatment with glucagon-like peptide-1 receptor agonists. An ultrasound visualisation score (A: no limitations - D: severe limitations) was used. ATI, SWE and SWD were measured, irrespective of visualisation score, and compared to clinical data, serological measures and depth of measurement. Scan-rescan reproducibility measurements were performed, both for continuous measures using intraclass correlation coefficient (ICC) and for kappa coefficient using proposed reference thresholds for elevated/pathological values in children during fasting and free-breathing: > ATI 0.56 dB/cm/MHz, > SWE 4.9 kPa and > SWD 11.9 (m/s)/kHz. RESULTS: The median (min-max) age of the 56 patients (51.8% male) was 16.2 years (9.9; 18) and the median BMI standard deviation score (SDS) was 4.4 (2.7; 7.3). The distribution of the visibility score was A 5.5%, B 50%, C 41% and D 3.5%. The median (min-max) ATI, SWE and SWD values were 0.58 dB/cm/MHz (0.32; 0.97), 7.2 kPa (4.3; 19.6) and 14.3 (m/s)/kHz (8.9; 24.3) respectively. Both ATI (beta = -4.2; r(2) = 0.3; p < 0.0001) and SWD (beta = 0.14; r(2) = 0.17; p = 0.0033) were influenced by depth of measurement. A weak association was found between ATI and serum triglycerides (beta = 0.07; r(2) = 0.12; p = 0.015). SWE was associated with BMI-SDS (beta = 0.71; r(2) = 0.09; p = 0.035). No other significant associations were found. ICC was moderate for ATI (0.61), fair for SWE (0.46) and fair for SWD (0.51). Kappa coefficient was substantial for ATI (0.77), excellent for SWE (1.0) and moderate for SWD (0.53). CONCLUSION: When accounting for visualization score, multiple ultrasound liver biomarkers appear applicable in most children and adolescents with severe obesity. Median ATI, SWE and SWD values were all increased, compared to currently known paediatric normal values. However, median ATI was likely underestimated due to depth dependence of measurement. Although caution is advised in clinical decision-making due to fair-moderate reproducibility between scans, most importantly, the biomarkers appear capable of differentiating between non-affected and affected liver in children with severe obesity. CI - (c) 2025. The Author(s). FAU - Cetinic, Ivan AU - Cetinic I AD - Department of Radiology, Sahlgrenska University Hospital, Region Vastra Gotaland, Gothenburg, Sweden. ivan.cetinic@vgregion.se. AD - Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. ivan.cetinic@vgregion.se. FAU - de Lange, Charlotte AU - de Lange C AD - Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. AD - Department of Paediatric Radiology, Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Region Vastra Gotaland, Gothenburg, Sweden. FAU - Lagerstrand, Kerstin AU - Lagerstrand K AD - Department of Radiology, Sahlgrenska University Hospital, Region Vastra Gotaland, Gothenburg, Sweden. AD - Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Region Vastra Gotaland, Gothenburg, Sweden. FAU - Kindblom, Jenny M AU - Kindblom JM AD - Department of Paediatrics, Sahlgrenska University Hospital, Region Vastra Gotaland, Gothenburg, Sweden. AD - Department of Drug Treatment, Sahlgrenska University Hospital, Region Vastra Gotaland, Gothenburg, Sweden. AD - Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Sjogren, Lovisa AU - Sjogren L AD - Department of Paediatrics, Sahlgrenska University Hospital, Region Vastra Gotaland, Gothenburg, Sweden. AD - Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Hebelka, Hanna AU - Hebelka H AD - Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. AD - Department of Paediatric Radiology, Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Region Vastra Gotaland, Gothenburg, Sweden. LA - eng GR - 2023-01951/Vetenskapsradet/ GR - 2023-01951/Vetenskapsradet/ GR - GLS-99915/Barnhusdirektionen-Frimurarna, Sweden/ GR - GLS-1003185/Barnhusdirektionen-Frimurarna, Sweden/ GR - GLS-99915/Barnhusdirektionen-Frimurarna, Sweden/ GR - ALFGBG-965176/Swedish Goverment and County Council, Sweden/ GR - ALFGBG-965176/Swedish Goverment and County Council, Sweden/ GR - M23-0067/Ake Wiberg Stiftelse/ GR - M23-0067/Ake Wiberg Stiftelse/ GR - 2022-012/Jerring Fundation/ GR - 2023-386/Jerring Foundation/ PT - Journal Article DEP - 20250516 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Adolescent MH - Child MH - Male MH - Female MH - Biomarkers/blood MH - Elasticity Imaging Techniques MH - *Pediatric Obesity/complications MH - *Obesity, Morbid/complications MH - Reproducibility of Results MH - Feasibility Studies MH - *Liver/diagnostic imaging MH - Ultrasonography MH - *Fatty Liver/diagnostic imaging/etiology MH - Liver Cirrhosis/diagnostic imaging PMC - PMC12083147 OTO - NOTNLM OT - Attenuation imaging OT - Elastography OT - Fibrosis OT - Inflammation OT - Liver disease OT - Multiparametric OT - Obesity OT - Steatosis OT - Ultrasonography OT - Ultrasound biomarkers COIS- Declarations. Ethics approval and consent to participate: Oral and written consent was obtained from all patients' caregivers (parents or legal guardians) prior to enrolment in the study. Both the patients and their caregivers were provided with detailed information about the study. In addition to the consent provided by their caregivers, patients aged 15 to 18 years also gave their own consent to participate. The study was conducted in accordance with the Declaration of Helsinki, and was approved by the regional ethics review board in Gothenburg (Dnr 634-18 and Dnr 2022-04524-02). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/05/17 17:02 MHDA- 2025/05/17 17:03 PMCR- 2025/05/16 CRDT- 2025/05/16 23:38 PHST- 2024/11/01 00:00 [received] PHST- 2025/05/07 00:00 [accepted] PHST- 2025/05/17 17:03 [medline] PHST- 2025/05/17 17:02 [pubmed] PHST- 2025/05/16 23:38 [entrez] PHST- 2025/05/16 00:00 [pmc-release] AID - 10.1186/s12887-025-05750-1 [pii] AID - 5750 [pii] AID - 10.1186/s12887-025-05750-1 [doi] PST - epublish SO - BMC Pediatr. 2025 May 16;25(1):390. doi: 10.1186/s12887-025-05750-1. PMID- 40380146 OWN - NLM STAT- MEDLINE DCOM- 20250516 LR - 20250604 IS - 1475-2875 (Electronic) IS - 1475-2875 (Linking) VI - 24 IP - 1 DP - 2025 May 16 TI - Consistency and reproducibility of independent feedings using blood from two consecutive days at varying Plasmodium falciparum gametocyte densities based on both direct membrane feeding assay and direct skin feeding assay. PG - 154 LID - 10.1186/s12936-025-05360-3 [doi] LID - 154 AB - BACKGROUND: New malaria control tools are needed to prevent the transmission of parasites from the host to the mosquito vector and vice versa. The infectiousness of Plasmodium falciparum gametocytes obtained from individuals to laboratory-reared mosquitoes should be quantified to employ easily applicable assays for evaluating transmission-blocking interventions. This study aimed to establish the relationship between parasite transmission from humans to mosquitoes both within a person and across persons by assessing the variation in the proportion of infected mosquitoes with at least one oocyst (oocyst prevalence) in a direct membrane feeding assay (DMFA) and direct skin landing feeding assay (DSFA) performed at two consecutive time points in the same human subject with P. falciparum gametocytaemia. METHODS: A total of 400 adults without symptoms of malaria residing in Western Kenya were screened for the presence of P. falciparum gametocytes. Individuals who tested positive had DMFAs and DSFAs on two subsequent days of feeding, baseline and final visit, to compare mosquito infection rates between the two feeds. RESULTS: Blood samples from 42 individuals testing positive for gametocytes underwent mosquito infection assays. Survival rates of mosquitoes after feeding at baseline and final visit were 13.2 and 11.6 days for DMFA and 12.1 and 11.4 days for DSFA, respectively. The mean oocyst prevalence on feeding at baseline and final visit was 6.3% and 2.2% for DMFA and 5.2% and 2.3% for DSFA, respectively. A not significantly lower prevalence was not observed on at final visit (- 0.016% for DMFA, p = 0.795) and -0.025% for DSFA, p = 0.711 compared to feeding at baseline. The correlation of oocyst prevalence between feeding baseline and final visit for both was low (0.3 95%CI (0.15, 0.51). Exploratory analysis suggests a lower probability of infection on the second day, with lower oocyst density. CONCLUSIONS: These findings have implications for future studies and limit the utility of before-after designs in testing transmission-blocking interventions. The findings show comparable infection rates in both DMFA and DSFA, which allows use of less invasive membrane assays in future studies. Trial registration NCT04666350. CI - (c) 2025. The Author(s). FAU - Akala, Hoseah Miima AU - Akala HM AD - Walter Reed Army Institute of Research-Africa, Kenya Medical Research Institute, Kisumu, Kenya. Hosea.Akala@usamru-k.org. FAU - Aponte, John J AU - Aponte JJ AD - PATH, Geneva, Switzerland. FAU - Achola, Millicent Anyango AU - Achola MA AD - Walter Reed Army Institute of Research-Africa, Kenya Medical Research Institute, Kisumu, Kenya. FAU - Juma, Dennis W AU - Juma DW AD - Walter Reed Army Institute of Research-Africa, Kenya Medical Research Institute, Kisumu, Kenya. FAU - Opot, Benjamin H AU - Opot BH AD - Walter Reed Army Institute of Research-Africa, Kenya Medical Research Institute, Kisumu, Kenya. FAU - Maisiba, Risper N AU - Maisiba RN AD - Walter Reed Army Institute of Research-Africa, Kenya Medical Research Institute, Kisumu, Kenya. FAU - Okoth, Raphael O AU - Okoth RO AD - Walter Reed Army Institute of Research-Africa, Kenya Medical Research Institute, Kisumu, Kenya. FAU - Juma, Jackline A AU - Juma JA AD - Walter Reed Army Institute of Research-Africa, Kenya Medical Research Institute, Kisumu, Kenya. FAU - Mwakio, Edwin W AU - Mwakio EW AD - Walter Reed Army Institute of Research-Africa, Kenya Medical Research Institute, Kisumu, Kenya. FAU - Mwalo, Maurine A AU - Mwalo MA AD - Walter Reed Army Institute of Research-Africa, Kenya Medical Research Institute, Kisumu, Kenya. FAU - Oullo, David O AU - Oullo DO AD - Walter Reed Army Institute of Research-Africa, Kenya Medical Research Institute, Kisumu, Kenya. FAU - Abuom, David AU - Abuom D AD - Walter Reed Army Institute of Research-Africa, Kenya Medical Research Institute, Kisumu, Kenya. FAU - Garges, Eric C AU - Garges EC AD - Walter Reed Army Institute of Research Africa, Kisumu, Kenya. FAU - Eyase, Fredrick L AU - Eyase FL AD - Walter Reed Army Institute of Research-Africa, Kenya Medical Research Institute, Kisumu, Kenya. FAU - Tina, Lucas Otieno AU - Tina LO AD - Walter Reed Army Institute of Research-Africa, Kenya Medical Research Institute, Kisumu, Kenya. FAU - Copeland, Nathanial K AU - Copeland NK AD - Walter Reed Army Institute of Research-Africa, Kenya Medical Research Institute, Kisumu, Kenya. FAU - Roth, Amanda AU - Roth A AD - Medical Communications for Combat Casualty Care, Fort Detrick, MD, USA. FAU - Mutunga, James AU - Mutunga J AD - Walter Reed Army Institute of Research-Africa, Kenya Medical Research Institute, Kisumu, Kenya. AD - Biology Program, School of Science, Engineering and Technology, Pennsylvania State University-Harrisburg, Middletown, PA, USA. FAU - Onyango, Irene AU - Onyango I AD - Walter Reed Army Institute of Research-Africa, Kenya Medical Research Institute, Kisumu, Kenya. FAU - Johnson, Jaree AU - Johnson J AD - Armed Forces Pest Management Board, Silver Spring, MD, USA. FAU - Ogutu, Bernhards R AU - Ogutu BR AD - Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya. FAU - Sifuna, Peter AU - Sifuna P AD - Walter Reed Army Institute of Research-Africa, Kenya Medical Research Institute, Kisumu, Kenya. FAU - Hutter, Jack AU - Hutter J AD - Walter Reed Army Institute of Research Africa, Kisumu, Kenya. FAU - Mercer, Laina AU - Mercer L AD - PATH, Seattle, WA, USA. FAU - Raine, Mike AU - Raine M AD - PATH, Seattle, WA, USA. FAU - Moore, Valerie AU - Moore V AD - PATH, Seattle, WA, USA. FAU - Ivinson, Karen AU - Ivinson K AD - PATH, Geneva, Switzerland. FAU - Wu, Yimin AU - Wu Y AD - PATH, Seattle, WA, USA. FAU - Andagalu, Ben AU - Andagalu B AD - Walter Reed Army Institute of Research-Africa, Kenya Medical Research Institute, Kisumu, Kenya. FAU - Ockenhouse, Christian F AU - Ockenhouse CF AD - PATH, Seattle, WA, USA. LA - eng SI - ClinicalTrials.gov/NCT04666350 GR - OPP1191923 / INV-007217/Bill & Melinda Gates Foundation/ PT - Journal Article PT - Observational Study DEP - 20250516 PL - England TA - Malar J JT - Malaria journal JID - 101139802 SB - IM MH - Adolescent MH - Adult MH - Animals MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - *Anopheles/parasitology/physiology MH - Feeding Behavior MH - Kenya MH - *Malaria, Falciparum/transmission/parasitology MH - *Mosquito Vectors/parasitology/physiology MH - *Plasmodium falciparum/physiology/isolation & purification MH - Reproducibility of Results PMC - PMC12085032 OTO - NOTNLM OT - Before-after OT - Clinical trial design OT - Gametocytes OT - Malaria OT - Transmission blocking COIS- Declarations. Ethics approval and consent to participate: The study protocol was approved by the Ethical Review Committee of the Kenya Medical Research Institute (KEMRI SSC Protocol No: 4106) and the Walter Reed Army Institute of Research Institutional Review Board (WRAIR IRB Protocol No: WRAIR#2610). Written informed consent was obtained from all study participants prior to their enrollment in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/05/17 17:01 MHDA- 2025/05/17 17:02 PMCR- 2025/05/16 CRDT- 2025/05/16 23:37 PHST- 2024/05/21 00:00 [received] PHST- 2025/04/01 00:00 [accepted] PHST- 2025/05/17 17:02 [medline] PHST- 2025/05/17 17:01 [pubmed] PHST- 2025/05/16 23:37 [entrez] PHST- 2025/05/16 00:00 [pmc-release] AID - 10.1186/s12936-025-05360-3 [pii] AID - 5360 [pii] AID - 10.1186/s12936-025-05360-3 [doi] PST - epublish SO - Malar J. 2025 May 16;24(1):154. doi: 10.1186/s12936-025-05360-3. PMID- 40379739 OWN - NLM STAT- MEDLINE DCOM- 20250516 LR - 20250527 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 May 16 TI - Development and validation of a model for predicting the risks for delayed onset of lactogenesis stage II for Chinese pregnant women. PG - 17074 LID - 10.1038/s41598-025-01597-9 [doi] LID - 17074 AB - Delayed onset lactogenesis II has adverse effects on breastfeeding and neonatal health. This study aimed to determine the risk factors of DOL II, develop a predictive model for DOL II, and test its validity. This was a retrospective cohort study. A total of 450 pregnant women were involved in this study, including 112 cases with DOL II and 338 cases without DOL II, who were hospitalized between October 2023 and April 2024. Univariate and multivariate logistic regression analyses were conducted to determine the risk factors of DOL II, which were then included in the nomogram. The performance of the nomogram model was evaluated by the area under the receiver operating curve, calibration curve, and Hosmer-Lemeshow test. Decision curve analysis was used to evaluate the clinical efficacy of the nomogram. The results showed that maternal age, pre-pregnancy BMI, gestational age, parity, delivery mode, length of stage II labor, gestational diabetes, EPDS, maternal-infant separation, breastfeeding education during pregnancy, formula use, and onset of breastfeeding within the first hour were independent risk factors. In the derivation cohort, the AUC was 0.786. Youden index was 1.526, with a sensitivity of 0.781 and a specificity of 0.745. In the verification cohort, AUC was 0.748. The nomogram model has good consistency and performance, which can identify women who are at high risk of DOL II. CI - (c) 2025. The Author(s). FAU - Li, Wenting AU - Li W AD - Department of Obstetrics, The Affiliated Hospital of Qingdao University, Qingdao, China. FAU - Kuang, Guofang AU - Kuang G AD - Department of Obstetrics, The Affiliated Hospital of Qingdao University, Qingdao, China. FAU - Chen, Yanqiu AU - Chen Y AD - Department of Obstetrics, The Affiliated Hospital of Qingdao University, Qingdao, China. FAU - Yu, Peng AU - Yu P AD - Department of Obstetrics, The Affiliated Hospital of Qingdao University, Qingdao, China. FAU - Zhang, Meng AU - Zhang M AD - Department of Obstetrics, The Affiliated Hospital of Qingdao University, Qingdao, China. zhangmeng_qd@126.com. LA - eng GR - QDFY+X 2023125/the Clinical Medicine +X Project of the Affiliated Hospital of Qingdao University/ PT - Journal Article PT - Validation Study DEP - 20250516 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - Chinese people SB - IM MH - Humans MH - Female MH - Pregnancy MH - Adult MH - Risk Factors MH - Retrospective Studies MH - Nomograms MH - Breast Feeding MH - *Lactation/physiology MH - China/epidemiology MH - ROC Curve MH - Maternal Age MH - *Lactation Disorders/epidemiology/etiology MH - East Asian People PMC - PMC12084521 OTO - NOTNLM OT - Breastfeeding OT - Delayed onset of lactogenesis II (DOL II) OT - Nomogram model OT - Pregnant woman OT - Risk factors COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/05/17 17:01 MHDA- 2025/05/17 17:02 PMCR- 2025/05/16 CRDT- 2025/05/16 23:20 PHST- 2024/11/16 00:00 [received] PHST- 2025/05/07 00:00 [accepted] PHST- 2025/05/17 17:02 [medline] PHST- 2025/05/17 17:01 [pubmed] PHST- 2025/05/16 23:20 [entrez] PHST- 2025/05/16 00:00 [pmc-release] AID - 10.1038/s41598-025-01597-9 [pii] AID - 1597 [pii] AID - 10.1038/s41598-025-01597-9 [doi] PST - epublish SO - Sci Rep. 2025 May 16;15(1):17074. doi: 10.1038/s41598-025-01597-9. PMID- 40379351 OWN - NLM STAT- MEDLINE DCOM- 20250516 LR - 20260820 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 5 DP - 2025 May 16 TI - Causal analysis of undernutrition among adolescents in the context of the agrarian community of North-West Ethiopia: a general structural equation modelling approach. PG - e080359 LID - 10.1136/bmjopen-2023-080359 [doi] LID - e080359 AB - OBJECTIVE: This study was conducted to evaluate the causal analysis of undernutrition among adolescents in the context of the agrarian community of North-West Ethiopia. DESIGN: A community-based case-control study was conducted among 149 cases and 297 control adolescents. SETTING: Agrarian communities of North-West Ethiopia. PARTICIPANTS: Adolescents aged 10-19 years, who reside in a randomly selected study setting. OUTCOME MEASURES: The stunting and thinness nutritional status of adolescents was determined using the WHO AnthroPlus 2010 software. A general structural equation modelling approach was used to determine a multicausal analysis of undernutrition. The Food Frequency Questionnaire was tested for internal reliability among 30 adolescents. The reliability test for the actual dietary tool was done using Cronbach's alpha coefficient (alpha), which was 0.79. The model adequacy was tested using the Akaike information criterion and Bayesian information criterion. The significant direct and indirect determinants were identified with a value of p<0.05. RESULT: Adolescents with lower traditional and mixed dietary pattern consumption habits were determinant factors for stunting with adjusted beta=0.65, 95% CL (0.143 to 1.159) with a value of p=0.012, adjusted beta=2.697, 95% CL (0.563 to 4.831) with a value of p=0.013, respectively. Breakfast eating frequency had a negative indirect determinant factor on the reduction of stunting via lower traditional habits, with adjusted beta=-0.207 (-0.299 to-0.116) with a value of p=0.001, and higher consumption habits of animal sources with traditional alcoholic drinking habits with adjusted beta=-0.163, 95% CL (-0.260 to -0.065) with a value of p=0.001. Whereas breakfast eating frequency had a direct influence on thinness with adjusted beta=-0.332, 95% CL (-0.588 to -0.076) with a value of p=0.011, and an indirect influence via dietary patterns for both stunting and thinness (p<0.05). CONCLUSION: Dietary patterns and breakfast-eating frequency were direct and indirect determinant factors for adolescents' stunting and thinness. Public health interventions should be implemented to reduce stunting and thinness by improving the dietary feeding and breakfast consumption habits of adolescents and strengthening the national deworming programmes in study areas and similar settings. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Agedew, Eskezyiaw AU - Agedew E AUID- ORCID: 0000-0001-7452-6054 AD - Public Health, Debre Markos University, Debre Markos, Amhara, Ethiopia esk1agid@gmail.com. FAU - Abebe, Zeweter AU - Abebe Z AUID- ORCID: 0009-0003-0798-1438 AD - Center for Food Science and Nutrition, Addis Ababa University, Addis Ababa, Ethiopia. FAU - Ayelign, Abebe AU - Ayelign A AUID- ORCID: 0000-0003-3877-5314 AD - Center for Food Science and Nutrition, Addis Ababa University, Addis Ababa, Ethiopia. LA - eng PT - Journal Article DEP - 20250516 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Ethiopia/epidemiology MH - Adolescent MH - Male MH - Female MH - *Malnutrition/epidemiology/etiology MH - Child MH - Case-Control Studies MH - Young Adult MH - *Growth Disorders/epidemiology/etiology MH - Nutritional Status MH - *Thinness/epidemiology/etiology MH - Latent Class Analysis MH - *Feeding Behavior MH - *Diet MH - Bayes Theorem PMC - PMC12086883 OTO - NOTNLM OT - Adolescents OT - Body Mass Index OT - NUTRITION & DIETETICS OT - Public health COIS- Competing interests: None declared. EDAT- 2025/05/17 17:02 MHDA- 2025/05/17 17:03 PMCR- 2025/05/16 CRDT- 2025/05/16 20:53 PHST- 2025/05/17 17:03 [medline] PHST- 2025/05/17 17:02 [pubmed] PHST- 2025/05/16 20:53 [entrez] PHST- 2025/05/16 00:00 [pmc-release] AID - bmjopen-2023-080359 [pii] AID - 10.1136/bmjopen-2023-080359 [doi] PST - epublish SO - BMJ Open. 2025 May 16;15(5):e080359. doi: 10.1136/bmjopen-2023-080359. PMID- 40379027 OWN - NLM STAT- MEDLINE DCOM- 20250704 LR - 20260518 IS - 1541-6100 (Electronic) IS - 0022-3166 (Linking) VI - 155 IP - 7 DP - 2025 Jul TI - Application-Based Bioelectrical Impedance Analysis Provides Accurate Body Composition Parameters in a More Cost-Efficient and Time-Efficient Way. PG - 2443-2448 LID - S0022-3166(25)00295-0 [pii] LID - 10.1016/j.tjnut.2025.05.013 [doi] AB - BACKGROUND: In clinical practice, there is an increasing demand for methods that provide accurate, precise, and real-time body composition measurements while reducing costs and data collection time. OBJECTIVES: This study aimed to evaluate the validity of an application-based bioelectric impedance analysis (BIA) system for determining body composition compared with a standard BIA method. METHODS: A total of 109 individuals with type 1 diabetes (56 men and 53 women), aged 18-70 y, with a body mass index of 25.0-35.0 kg/m(2) and glycated hemoglobin concentrations of 7.0%-9.0%, were recruited. Participants were randomly assigned to start with either the application-based BIA system or the standard method (A-wave BIA quantum-V) and then switched to the other method. Anthropometric parameters, blood pressure, and metabolic profiles were also assessed. RESULTS: The comparison between the 2 methods showed a negligible difference in resistance but a significant difference in reactance (-4.9%). The degree of consistency was excellent for both resistance [intraclass correlation coefficient (ICC) = 0.990, P < 0.001] and reactance (ICC = 0.903, P < 0.001), with individual differences falling within acceptable ranges. Furthermore, body composition parameters, including fat-free mass, fat mass, skeletal muscle mass, total body water, and extracellular water, showed only minor and nonsignificant differences between the 2 methods. CONCLUSIONS: These findings suggest that the application-based BIA system is a valid and reliable tool for assessing body composition, offering healthcare professionals, including dietitians and nutritionists, a cost-effective and time-efficient alternative to standard BIA methods. CI - Copyright (c) 2025 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - D'Abbronzo, Giovanna AU - D'Abbronzo G AD - Nutrition, Diabetes and Metabolism Research Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy. FAU - Scida, Giuseppe AU - Scida G AD - Nutrition, Diabetes and Metabolism Research Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy. FAU - Quaglia, Cinzia AU - Quaglia C AD - Nutrition, Diabetes and Metabolism Research Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy. FAU - Rivellese, Angela A AU - Rivellese AA AD - Nutrition, Diabetes and Metabolism Research Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy. FAU - Bozzetto, Lutgarda AU - Bozzetto L AD - Nutrition, Diabetes and Metabolism Research Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy. FAU - Annuzzi, Giovanni AU - Annuzzi G AD - Nutrition, Diabetes and Metabolism Research Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy. FAU - Vitale, Marilena AU - Vitale M AD - Nutrition, Diabetes and Metabolism Research Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy. Electronic address: marilena.vitale@unina.it. LA - eng SI - ClinicalTrials.gov/NCT05936242 PT - Journal Article PT - Randomized Controlled Trial DEP - 20250514 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 SB - IM MH - Humans MH - *Electric Impedance MH - *Body Composition MH - Adult MH - Male MH - Female MH - Middle Aged MH - Young Adult MH - Adolescent MH - Aged MH - Diabetes Mellitus, Type 1/physiopathology MH - Body Mass Index MH - Cost-Benefit Analysis OTO - NOTNLM OT - application-based system OT - bioelectrical impedance analysis OT - extracellular water OT - fat-free mass OT - remote health monitoring OT - telemedicine OT - total body water COIS- Conflict of interest METEDA LLC kindly supplied the application-based BIA system for the study. METEDA LLC had no role in study design, collection, analysis, and interpretation of data, writing of the manuscript, and the decision to submit the article for publication. The authors report no conflicts of interest. EDAT- 2025/05/17 17:02 MHDA- 2025/07/05 00:28 CRDT- 2025/05/16 19:36 PHST- 2025/04/24 00:00 [received] PHST- 2025/05/08 00:00 [accepted] PHST- 2025/07/05 00:28 [medline] PHST- 2025/05/17 17:02 [pubmed] PHST- 2025/05/16 19:36 [entrez] AID - S0022-3166(25)00295-0 [pii] AID - 10.1016/j.tjnut.2025.05.013 [doi] PST - ppublish SO - J Nutr. 2025 Jul;155(7):2443-2448. doi: 10.1016/j.tjnut.2025.05.013. Epub 2025 May 14. PMID- 40378893 OWN - NLM STAT- MEDLINE DCOM- 20250907 LR - 20260525 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 214 DP - 2025 Oct 1 TI - "Did I buy that just now?" - Investigating factors influencing the accuracy of food choice self-reports in a simulated online grocery store. PG - 108032 LID - S0195-6663(25)00185-0 [pii] LID - 10.1016/j.appet.2025.108032 [doi] AB - Food choices profoundly impact population health and the environment. Related research often relies on self-reported data, which is prone to biases, compromising the accuracy and validity of conclusions about consumer behavior. There are few systematic validations of self-reported data with behavioral data, or investigations of predictors for their accuracy. Consequently, this study examined possible predictors for the accuracy of self-reports by comparing them with observed food choices. Participants (N = 290) completed a shopping task in a simulated online grocery store, followed immediately by shopping self-reports and a survey, therefore minimizing recall-related distortions to self-reports due to time delays. Nevertheless, on average, participants had reporting errors in 3.81 out of 29 categories, with accuracy as low as a mean of 44 % for categories with no cues provided. Reporting accuracy significantly increased to 78 % with image-based memory aids for specific product categories (e.g., apples), and to 89 % with text-based memory aids for general categories (e.g., vegetables). Contrary to expectations related to social desirability bias, processed foods, often perceived as unhealthy, were overreported. Regression analysis revealed mental load during shopping, deliberation time per item, and dietary preferences as significant predictors of self-report accuracy, with mental load also predicting the accuracy of participants' estimates of the proportion of organic products in their shopping basket. Our findings show that even in conditions that minimize social desirability and recall limitations, substantial self-reporting errors persist. Accounting for mental load and product-specific biases is therefore necessary to enhance the validity of self-reports in food choice research. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Manzke, Leonie AU - Manzke L AD - School of Business, Economics and Society, Friedrich-Alexander-University Erlangen-Nurnberg, Lange Gasse 20, Nurnberg, 90403, Germany. Electronic address: leonie.manzke@fau.de. FAU - O'Sullivan, Kevin AU - O'Sullivan K AD - Chair of Information Management, ETH Zurich, Weinbergstrasse 56/58, Zurich, 8092, Switzerland. FAU - Tiefenbeck, Verena AU - Tiefenbeck V AD - School of Business, Economics and Society, Friedrich-Alexander-University Erlangen-Nurnberg, Lange Gasse 20, Nurnberg, 90403, Germany. LA - eng PT - Journal Article DEP - 20250514 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - Male MH - *Self Report MH - *Food Preferences/psychology MH - *Consumer Behavior MH - Adult MH - *Choice Behavior MH - Young Adult MH - Middle Aged MH - Adolescent MH - Mental Recall MH - Reproducibility of Results OTO - NOTNLM OT - Consumer decision-making OT - Food choice OT - Grocery shopping OT - Online grocery stores OT - Organic food OT - Processed food OT - Self-report accuracy COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/05/17 17:03 MHDA- 2025/09/08 00:32 CRDT- 2025/05/16 19:34 PHST- 2024/12/29 00:00 [received] PHST- 2025/04/24 00:00 [revised] PHST- 2025/04/29 00:00 [accepted] PHST- 2025/09/08 00:32 [medline] PHST- 2025/05/17 17:03 [pubmed] PHST- 2025/05/16 19:34 [entrez] AID - S0195-6663(25)00185-0 [pii] AID - 10.1016/j.appet.2025.108032 [doi] PST - ppublish SO - Appetite. 2025 Oct 1;214:108032. doi: 10.1016/j.appet.2025.108032. Epub 2025 May 14. PMID- 40378360 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250518 IS - 2767-3170 (Electronic) IS - 2767-3170 (Linking) VI - 4 IP - 5 DP - 2025 May TI - A non-specialist worker delivered digital assessment of cognitive development (DEEP) in young children: A longitudinal validation study in rural India. PG - e0000824 LID - 10.1371/journal.pdig.0000824 [doi] LID - e0000824 AB - Cognitive development in early childhood is critical for life-long well-being. Existing cognitive development surveillance tools require lengthy parental interviews and observations of children. Developmental Assessment on an E-Platform (DEEP) is a digital tool designed to address this gap by providing a gamified, direct assessment of cognition in young children which can be delivered by front-line providers in community settings. This longitudinal study recruited children from the SPRING trial in rural Haryana, India. DEEP was administered at 39 (SD 1; N = 1359), 60 (SD 5; N = 1234) and 95 (SD 4; N = 600) months and scores were derived using item response theory. Criterion validity was examined by correlating DEEP-score with age, Bayley's Scales of Infant Development (BSID-III) cognitive domain score at age 3 and Raven's Coloured Progressive Matrices (CPM) at age 8; predictive validity was examined by correlating DEEP-scores at preschool-age with academic performance at age 8 and convergent validity through correlations with height-for-age z-scores (HAZ), socioeconomic status (SES) and early life adversities. DEEP-score correlated strongly with age (r = 0.83, 95% CI 0.82 0.84) and moderately with BSID-III (r = 0.50, 0.39 - 0.60) and CPM (r = 0.37; 0.30 - 0.44). DEEP-score at preschool-age predicted academic outcomes at school-age (0.32; 0.25 - 0.41) and correlated positively with HAZ and SES and negatively with early life adversities. DEEP provides a valid, scalable method for cognitive assessment. It's integration into developmental surveillance programs could aid in monitoring and early detection of cognitive delays, enabling timely interventions. CI - Copyright: (c) 2025 Bhavnani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Bhavnani, Supriya AU - Bhavnani S AD - Child Development Group, Sangath, Saket, Delhi, India. FAU - Ranjan, Alok AU - Ranjan A AD - Child Development Group, Sangath, Saket, Delhi, India. FAU - Mukherjee, Debarati AU - Mukherjee D AD - Indian Institute of Public Health Bengaluru, Public Health Foundation of India, Bengaluru, India. FAU - Divan, Gauri AU - Divan G AD - Child Development Group, Sangath, Saket, Delhi, India. FAU - Prakash, Amit AU - Prakash A AD - Child Development Group, Sangath, Saket, Delhi, India. FAU - Yadav, Astha AU - Yadav A AD - Child Development Group, Sangath, Saket, Delhi, India. FAU - Lal, Chaman AU - Lal C AD - Child Development Group, Sangath, Saket, Delhi, India. FAU - Gajria, Diksha AU - Gajria D AD - Child Development Group, Sangath, Saket, Delhi, India. FAU - Irfan, Hiba AU - Irfan H AD - Child Development Group, Sangath, Saket, Delhi, India. FAU - Sharma, Kamal Kant AU - Sharma KK AD - Child Development Group, Sangath, Saket, Delhi, India. FAU - Todkar, Smita AU - Todkar S AD - Child Development Group, Sangath, Saket, Delhi, India. AD - Centre for Doctoral Studies, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India. FAU - Patel, Vikram AU - Patel V AUID- ORCID: 0000-0003-1066-8584 AD - Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, United States of America. FAU - McCray, Gareth AU - McCray G AD - Institute for Global Health and Wellbeing, School of Medicine, Keele University, Staffordshire, United Kingdom. LA - eng GR - WT_/Wellcome Trust/United Kingdom PT - Journal Article DEP - 20250516 PL - United States TA - PLOS Digit Health JT - PLOS digital health JID - 9918335064206676 PMC - PMC12084064 COIS- The authors have declared that no competing interests exist. EDAT- 2025/05/16 18:31 MHDA- 2025/05/16 18:32 PMCR- 2025/05/16 CRDT- 2025/05/16 16:12 PHST- 2024/12/07 00:00 [received] PHST- 2025/03/13 00:00 [accepted] PHST- 2025/05/16 18:32 [medline] PHST- 2025/05/16 18:31 [pubmed] PHST- 2025/05/16 16:12 [entrez] PHST- 2025/05/16 00:00 [pmc-release] AID - PDIG-D-24-00547 [pii] AID - 10.1371/journal.pdig.0000824 [doi] PST - epublish SO - PLOS Digit Health. 2025 May 16;4(5):e0000824. doi: 10.1371/journal.pdig.0000824. eCollection 2025 May. PMID- 40377884 OWN - NLM STAT- MEDLINE DCOM- 20250916 LR - 20250918 IS - 1741-0444 (Electronic) IS - 0140-0118 (Print) IS - 0140-0118 (Linking) VI - 63 IP - 10 DP - 2025 Oct TI - Analysis of anthropometric measurements in U-15 female weightlifters using Kinect camera and comparison with traditional methods. PG - 3003-3018 LID - 10.1007/s11517-025-03373-3 [doi] AB - Anthropometric measurements are important in a wide range of areas, from athlete selection to performance analysis and medical exercise applications. With its portable and cost-effective structure, Microsoft Kinect offers significant advantages in measuring human movements and provides valuable data in the fields of sports science and medicine. The aim of this study is to compare certain anthropometric measurements of adolescent female weightlifters in the U-15 age category with Kinect V2 and traditional methods. Twelve athletes who won medals in international weightlifting championships were included in the study. Anthropometric evaluations of each athlete were performed using Kinect V2 and the traditional method. Differences between measurements were analyzed with Bland-Altman plots and Pearson correlation coefficients. Kinect was found to exhibit less variability and higher coherency in measurements of humerus, forearm, trochanter-tibiale laterale, tibial lengths, and shoulder width. It has been observed that the traditional method provides more coherence results in hand length measurements. Kinect was found to exhibit less variability and higher coherency in measurements of forearm, trochanter-tibiale laterale, tibial lengths, and shoulder width, indicating its potential as a reliable tool for these parameters. Notably, Kinect demonstrated high reliability for tibial length (ICC 0.918) and moderate reliability for trochanter-tibiale laterale (ICC 0.737), showing its effectiveness in these measurements. Additionally, Kinect exhibited lower variation and higher coherency in most measurements compared to manual methods, supporting its consistency and repeatability in anthropometric assessments. These results indicate that Kinect may be a suitable tool for some measurements but that traditional methods may be preferable for hand length measurements. These findings suggest that Kinect can be used effectively for certain anthropometric measurements in sports and medical science. CI - (c) 2025. The Author(s). FAU - Isik, Bulent AU - Isik B AUID- ORCID: 0000-0001-8753-8302 AD - Departments of Physiology, Medical School, University of Karamanoglu Mehmetbey, 70200, Karaman, Turkey. FAU - Erdagi, Kenan AU - Erdagi K AUID- ORCID: 0000-0002-2338-6546 AD - Departments of Physical Education and Sports, Ahmet Kelesoglu Faculty of Education, Necmettin Erbakan University, 42090, Konya, Turkey. k.erdagi@erbakan.edu.tr. FAU - Orucu, Serkan AU - Orucu S AUID- ORCID: 0000-0001-9905-2908 AD - Vocational School of Technical Sciences, Computer Technologies Program, Karamanoglu Mehmetbey University, 70200, Karaman, Turkey. FAU - Osmanoglu, Usame Omer AU - Osmanoglu UO AUID- ORCID: 0000-0002-1198-2447 AD - Departments of Biostatistics, Medical School, University of Karamanoglu Mehmetbey, 70200, Karaman, Turkey. FAU - Ozbay, Erkan AU - Ozbay E AUID- ORCID: 0000-0002-8781-3877 AD - Karamanoglu Mehmetbey University Vocational School of Health, 70200, Karaman, Turkey. LA - eng GR - 14-M-24/Karamanoglu Mehmetbey Universitesi/ PT - Comparative Study PT - Journal Article DEP - 20250516 PL - United States TA - Med Biol Eng Comput JT - Medical & biological engineering & computing JID - 7704869 SB - IM MH - Humans MH - Female MH - *Anthropometry/methods MH - Adolescent MH - *Weight Lifting/physiology MH - Reproducibility of Results MH - Athletes PMC - PMC12436582 OTO - NOTNLM OT - Adolescent female weightlifters OT - Anthropometric measurement OT - Microsoft Kinect OT - Olympic style weightlifting OT - U-15 age category COIS- Declarations. Conflict of interests: The authors declare no competing interests Ethics approval and consent to participate: Institutional Review Board Statement: The study was conducted in accordance with the Declaration of Helsinki 2013, and approved by the Institutional Review Board of Karamanoglu Mehmetbey University Medicine Faculty Scientific Ethics Committee (approval number; 08-2024/11). Consent for publication: Written consents for publication were obtained from all subjects and their parent/legal guardian shown in Figs. 1, 2, and 3, separately. All authors have read and agreed to the published version of the manuscript. Informed consent: An informed consent was obtained from all subjects and their parent/legal guardian involved in the study. Moreover, written informed consent was obtained from all individuals whose images appear in this study. EDAT- 2025/05/16 13:00 MHDA- 2025/09/16 13:02 PMCR- 2025/05/16 CRDT- 2025/05/16 11:21 PHST- 2025/01/24 00:00 [received] PHST- 2025/04/23 00:00 [accepted] PHST- 2025/09/16 13:02 [medline] PHST- 2025/05/16 13:00 [pubmed] PHST- 2025/05/16 11:21 [entrez] PHST- 2025/05/16 00:00 [pmc-release] AID - 10.1007/s11517-025-03373-3 [pii] AID - 3373 [pii] AID - 10.1007/s11517-025-03373-3 [doi] PST - ppublish SO - Med Biol Eng Comput. 2025 Oct;63(10):3003-3018. doi: 10.1007/s11517-025-03373-3. Epub 2025 May 16. PMID- 40376492 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250517 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 16 DP - 2025 TI - Olympic combat sports and mental health in children and adolescents with disability: a systematic review of controlled trials. PG - 1567978 LID - 10.3389/fpsyg.2025.1567978 [doi] LID - 1567978 AB - INTRODUCTION: Children and adolescents with disabilities face increased mental health challenges and lack of access to exercise. Olympic combat sports (OCS) such as judo, taekwondo, and others might encourage social engagement, self-control, and resilience. However, not much is known about their mental health impact on this population. METHODS: Following PRISMA-P protocols (PROSPERO registration: CRD42023452489), we searched seven databases for randomized controlled trials or non-randomized trials that evaluated the impact of OCS on mental health in children and adolescents (5-18 years) with developmental or physical disabilities. The key findings fell into 11 domains across mental illness attitudes, social skills, and mental health literacy. We also extracted individual (e.g., age) and social (e.g., family participation) moderating factors. Rob 2.0 (randomized trials) and ROBINS-I (non-randomized trials) were used to measure the risk of bias. RESULTS: Twelve studies (seven randomized, five controlled trials) conducted during 1975-2022, encompassing 436 participants (11.4 +/- 2.8 years), were included. There were significant improvements (p < 0.05) in stereotypy, communication, social-emotional functioning, and executive function, with occasional improvements in self-esteem and stress management. Several experiments reported rapid hormonal changes (e.g., cortisol) immediately after OCS, particularly among adolescents. Family involvement and age emerged as potential moderators, with older children and adolescents with engaged carers likely to benefit even more. DISCUSSIONS: Despite different study protocols, outcomes, and risk-of-bias thresholds, OCS interventions overwhelmingly seem to enhance mental health in children and adolescents with disabilities. More substantial, longer-term trials would be required to validate these findings, explain the processes, and evaluate safety. Programs based on OCS that address disabilities could provide broad pathways to physical activity and psychological development as part of a whole-person developmental model. CONCLUSION: This review indicates that OCS interventions have the potential to improve mental health outcomes for children and adolescents with disabilities by increasing social skills and executive functioning while better regulating stress. The diversity of samples and inadequate study designs necessitate additional high-quality research. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/view/CRD42023452489, CRD42023452489. CI - Copyright (c) 2025 Lee, Guidotti, Capranica, Pesce, Benzing, Hauck and Ciaccioni. FAU - Lee, Youngjun AU - Lee Y AD - Department of Kinesiology, Michigan State University, East Lansing, MI, United States. FAU - Guidotti, Flavia AU - Guidotti F AD - Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy. AD - Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, Italy. FAU - Capranica, Laura AU - Capranica L AD - Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy. FAU - Pesce, Caterina AU - Pesce C AD - Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy. FAU - Benzing, Valentin AU - Benzing V AD - Institute of Sport Science, University of Bern, Bern, Switzerland. FAU - Hauck, Janet AU - Hauck J AD - Department of Kinesiology, Michigan State University, East Lansing, MI, United States. FAU - Ciaccioni, Simone AU - Ciaccioni S AD - Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy. AD - Department of Education and Sport Sciences, Pegaso Telematic University, Naples, Italy. LA - eng PT - Journal Article PT - Systematic Review DEP - 20250501 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC12078338 OTO - NOTNLM OT - Olympic combat sports OT - adolescents OT - children OT - disability OT - mental health COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/05/16 11:46 MHDA- 2025/05/16 11:47 PMCR- 2025/05/01 CRDT- 2025/05/16 04:33 PHST- 2025/01/28 00:00 [received] PHST- 2025/04/18 00:00 [accepted] PHST- 2025/05/16 11:47 [medline] PHST- 2025/05/16 11:46 [pubmed] PHST- 2025/05/16 04:33 [entrez] PHST- 2025/05/01 00:00 [pmc-release] AID - 10.3389/fpsyg.2025.1567978 [doi] PST - epublish SO - Front Psychol. 2025 May 1;16:1567978. doi: 10.3389/fpsyg.2025.1567978. eCollection 2025. PMID- 40375171 OWN - NLM STAT- MEDLINE DCOM- 20250516 LR - 20250518 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 May 15 TI - Assessing family influence on adolescent healthy eating: insights from knowledge, attitudes, and practices in a cross-sectional survey in Hong Kong. PG - 1793 LID - 10.1186/s12889-025-22999-4 [doi] LID - 1793 AB - BACKGROUND: Poor dietary habits in adolescents contribute to the development of non-communicable diseases in adulthood. While family influence by parenting style, food parenting practice and household income on adolescent eating habits has been well-established, other family factors such as parental health conditions as well as the impact on dietary knowledge and attitudes in adolescents are underexplored. This study aimed to evaluate the relative importance of family factors on adolescent healthy eating using the knowledge, attitudes, and practices (KAP) model. METHODS: A cross-sectional online survey was conducted among parent-adolescent dyads recruited from a previous cohort study and secondary schools in Hong Kong. Adolescent healthy eating was assessed by a locally developed and validated KAP of Healthy Eating Questionnaire (KAP-HEQ). It evaluated knowledge on dietary recommendations, health outcomes and food choice; attitudes on outcome expectation, food preference, and self-efficacy; and practices on meal pattern and healthy/unhealthy food consumption. Parents reported on family factors including their KAP of healthy eating (KAP-HEQ), parenting style (Parenting Style and Dimensions Questionnaire), attitudes towards adolescent eating habit, food parenting practices, and family demographic characteristics such as employment status and household income. Multivariable linear regression was used to estimate the family influence on adolescent healthy eating. RESULTS: Two hundred seven dyads of parents (mean age = 46.14 years, 85.02% mothers, 80.19% married, 60.87% attained senior secondary education or above) and adolescents (mean age = 15.21 years, 48.31% female) completed the survey. Positive associations were found between dyad knowledge (beta = 0.28, p < 0.001), dyad attitudes (beta = 0.22, p < 0.001), and between adolescent practices and food parenting practices (beta = 0.18, p < 0.001) and parental employment status (part-time vs unemployed: beta = 4.08, p < 0.05). Negative associations were identified between adolescent attitudes and authoritative parenting style (beta = -0.11, p < 0.05) and household size (beta = -3.19, p < 0.05), and between adolescent practices and higher parental education levels (senior secondary or above vs primary or below: beta = -2.86, p < 0.05). DISCUSSION: The study found positive effects of parental dietary knowledge, attitudes, and food parenting practices on adolescent KAP of healthy eating. Interventions to enhance these three family facilitators should be included in strategies for promoting KAP of healthy eating among adolescents. CI - (c) 2025. The Author(s). FAU - Liu, Kiki S N AU - Liu KSN AD - Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. FAU - Chen, Julie Y AU - Chen JY AD - Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. juliechen@hku.hk. AD - Department of Family Medicine, The University of Hong Kong Shenzhen Hospital, Shenzhen, China. juliechen@hku.hk. FAU - Kang, Qi AU - Kang Q AD - Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. FAU - Sun, Kai-Sing AU - Sun KS AD - JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China. FAU - Tsang, Joyce P Y AU - Tsang JPY AD - S. K. Yee School of Health Sciences, Saint Francis University, Hong Kong SAR, China. FAU - Ip, Patrick AU - Ip P AD - Department of Paediatrics & Adolescent Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. FAU - Wong, Rosa S M AU - Wong RSM AD - Department of Paediatrics & Adolescent Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. AD - Department of Special Education and Counselling, The Education University of Hong Kong, Hong Kong SAR, China. FAU - Wong, Carlos K H AU - Wong CKH AD - Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. AD - Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. AD - Laboratory of Data Discovery for Health Limited (D24H), Hong Kong Science Park, Hong Kong SAR, China. AD - Department of Infectious Disease Epidemiology & Dynamics, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK. FAU - Lam, Cindy L K AU - Lam CLK AD - Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. AD - Department of Family Medicine, The University of Hong Kong Shenzhen Hospital, Shenzhen, China. LA - eng GR - 20212231/Health and Medical Research Fund/ PT - Journal Article DEP - 20250515 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Adolescent MH - *Health Knowledge, Attitudes, Practice MH - Female MH - Hong Kong MH - Male MH - *Diet, Healthy/psychology MH - Surveys and Questionnaires MH - Adult MH - Parenting/psychology MH - Feeding Behavior/psychology MH - *Parents/psychology MH - *Adolescent Behavior/psychology PMC - PMC12079827 OTO - NOTNLM OT - Adolescents OT - Family influence OT - Food parenting practices OT - Healthy eating OT - KAP COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Institutional Review Board of the University/Hospital Authority Hong Kong West Cluster (UW 22-289). Parents provided informed consent for themselves and their children, while adolescents consented individually before enrolling in the study. Consent for publication: Not applicable. Competing interests: CW was employed by the Laboratory of Data Discovery for Health Limited (D24H). The remaining authors declare that no conflicts of interest exist. EDAT- 2025/05/16 11:42 MHDA- 2025/05/16 11:43 PMCR- 2025/05/15 CRDT- 2025/05/15 23:44 PHST- 2024/11/27 00:00 [received] PHST- 2025/04/30 00:00 [accepted] PHST- 2025/05/16 11:43 [medline] PHST- 2025/05/16 11:42 [pubmed] PHST- 2025/05/15 23:44 [entrez] PHST- 2025/05/15 00:00 [pmc-release] AID - 10.1186/s12889-025-22999-4 [pii] AID - 22999 [pii] AID - 10.1186/s12889-025-22999-4 [doi] PST - epublish SO - BMC Public Health. 2025 May 15;25(1):1793. doi: 10.1186/s12889-025-22999-4. PMID- 40374236 OWN - NLM STAT- MEDLINE DCOM- 20250516 LR - 20260917 IS - 2053-8790 (Print) IS - 2053-8790 (Electronic) IS - 2053-8790 (Linking) VI - 12 IP - 1 DP - 2025 May 14 TI - Visceral fat, cardiovascular risk factors and quality of life in lupus activity categorised via complement C3. LID - 10.1136/lupus-2024-001423 [doi] LID - e001423 AB - BACKGROUND: Patients with lupus face increased cardiovascular risk linked to their autoimmune status. This study assesses the relationships between cardiovascular risk factors, lifestyle and health-related quality of life (HRQoL) concerning SLE activity categorised by complement C3. METHODS: 74 patients with SLE were recruited and stratified as active (C3 <90 mg/dL) or inactive (C3 >90 mg/dL), alongside 74 controls with obesity-related low-grade inflammation, at Hospital Universitario Puerta de Hierro Majadahonda. Anthropometric measurements, clinical and demographic data were recorded, and participants completed validated questionnaires on physical activity, dietary intake and HRQoL. Fasting blood samples were collected for metabolic determinations. Comparative analyses between SLE groups and controls, along with regression models adjusted for variables associated with disease activity, were performed. RESULTS: The inactive SLE group exhibited a less healthy adiposity profile compared with the active group (36.7% vs 33.2% total fat mass; 8.5 AU vs 6.5 AU visceral fat mass) and showed a higher prevalence of cardiovascular risk factors, including markers of obesity, hypertension, dyslipidaemia and increased waist circumference, along with worse HRQoL outcomes. Notably, age, body mass index and insulin resistance were associated with SLE inactivity, while fibrinogen correlated with disease activity as assessed by complement C3 levels. Interestingly, household composition as a sociodemographic variable (alone, couple/children/elderly or other) also showed an independent association with SLE activity. CONCLUSIONS: Inactive patients with SLE exhibited more adverse cardiovascular risk markers compared with active patients categorised by complement C3, even when glucocorticoid administration was accounted for. Additionally, this research highlights the potential influence of fibrinogen as well as metabolic and sociodemographic factors on disease activity. These findings emphasise the need for personalised precision management strategies such as measurement of fibrinogen levels and insulin resistance and sociodemographic considerations that address both cardiovascular risk and overall lifestyle plus exposome in patients with SLE and may partly explain SLE activity evolution. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Martinez-Urbistondo, Maria AU - Martinez-Urbistondo M AD - Internal Medicine Service, Puerta de Hierro University Hospital of Majadahonda, Majadahonda, Spain. FAU - Higuera-Gomez, Andrea AU - Higuera-Gomez A AUID- ORCID: 0000-0002-8680-6704 AD - Precision Nutrition and Cardiometabolic Health, IMDEA Food, Madrid, Spain andrea.higuera@alimentacion.imdea.org. AD - Department of Pharmacy and Nutrition, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid - Campus de Villaviciosa de Odon, Madrid, Spain. FAU - de Cuevillas, Begona AU - de Cuevillas B AD - Precision Nutrition and Cardiometabolic Health, IMDEA Food, Madrid, Spain. FAU - Cuevas-Sierra, Amanda AU - Cuevas-Sierra A AD - Precision Nutrition and Cardiometabolic Health, IMDEA Food, Madrid, Spain. FAU - Mellor-Pita, Susana AU - Mellor-Pita S AD - Internal Medicine Service, Puerta de Hierro University Hospital of Majadahonda, Majadahonda, Spain. FAU - Moreno-Torres, Victor AU - Moreno-Torres V AUID- ORCID: 0000-0002-9798-4514 AD - Puerta de Hierro University Hospital of Majadahonda, Majadahonda, Spain. AD - Health Sciences School and Medical Center, UNIR, Logrono, Spain. FAU - Vargas, Juan-Antonio AU - Vargas JA AD - Puerta de Hierro University Hospital of Majadahonda, Majadahonda, Spain. FAU - Castejon, Raquel AU - Castejon R AD - Puerta de Hierro University Hospital of Majadahonda, Majadahonda, Spain. FAU - Martinez, J Alfredo AU - Martinez JA AD - Precision Nutrition and Cardiometabolic Health, IMDEA Food, Madrid, Spain. AD - Biomedical Research Centre for Obesity Physiopathology and Nutrition Network (CIBEROBN), Instituto de Salud Carlos III (ISCIII), CIBERON, Madrid, Spain. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250514 PL - England TA - Lupus Sci Med JT - Lupus science & medicine JID - 101633705 RN - 0 (Complement C3) RN - 0 (C3 protein, human) SB - IM MH - Humans MH - *Complement C3/analysis/metabolism MH - Female MH - *Lupus Erythematosus, Systemic/complications/blood/physiopathology MH - Male MH - *Quality of Life MH - Adult MH - Middle Aged MH - Heart Disease Risk Factors MH - *Cardiovascular Diseases/epidemiology/etiology MH - *Intra-Abdominal Fat MH - Risk Factors MH - Case-Control Studies MH - Body Mass Index MH - Cross-Sectional Studies MH - Life Style MH - Obesity/epidemiology PMC - PMC12083274 OTO - NOTNLM OT - Cardiovascular Diseases OT - Health-Related Quality Of Life OT - Inflammation OT - Lupus Erythematosus, Systemic OT - Risk Factors COIS- Competing interests: None declared. EDAT- 2025/05/16 11:41 MHDA- 2025/05/16 11:42 PMCR- 2025/05/14 CRDT- 2025/05/15 20:53 PHST- 2024/10/16 00:00 [received] PHST- 2025/04/15 00:00 [accepted] PHST- 2025/05/16 11:42 [medline] PHST- 2025/05/16 11:41 [pubmed] PHST- 2025/05/15 20:53 [entrez] PHST- 2025/05/14 00:00 [pmc-release] AID - 12/1/e001423 [pii] AID - lupus-2024-001423 [pii] AID - 10.1136/lupus-2024-001423 [doi] PST - epublish SO - Lupus Sci Med. 2025 May 14;12(1):e001423. doi: 10.1136/lupus-2024-001423. PMID- 40373294 OWN - NLM STAT- Publisher LR - 20250515 IS - 1558-691X (Electronic) IS - 0033-2941 (Linking) DP - 2025 May 15 TI - Does the Use of Short-form Video Platforms Increase the Occurrence of Eating Disorders in Adolescents? A Study Based on Sex Differences. PG - 332941251343534 LID - 10.1177/00332941251343534 [doi] AB - Eating disorders, a common chronic condition among adolescesnts, show a strong positive correlation with individuals' social media use. Nonetheless, research on how the use of emerging short-form video platforms affects adolescent eating disorders is relatively sparse. Therefore, we examine the relationship between short-form video platform use and eating disorders in adolescents, exploring the mediating roles of body image comparison, body dissatisfaction, and sex differences in this relationship. A total of 795 high school students (mean age = 14.66 +/- 1.39 years, 451 girls) were surveyed in China using the Eating Attitudes Test as well as scales measuring short-form video platform use intensity, body image comparisons, and body dissatisfaction based on previously validated tools. Altogether, 9.2% of the sampled adolescents presented unsuitable eating behaviors, which suggested a risk of developing eating disorders. Further, we found significant positive associations among short-form video platform use, eating disorders, body image comparison, and body dissatisfaction. Additionally, one direct and three indirect paths showed a relationship between short-form video platform use and eating disorders. Short-form video platform use was more directly and closely related to eating disorders in boys and more indirectly related to eating disorders through body image comparisons in girls. These results validate relevant theories and provide suggestions on how to reduce eating disorders among adolescents. FAU - Fan, Liheng AU - Fan L AUID- ORCID: 0000-0003-4063-0106 AD - Institute of Psychology and Behavior, Henan University, Kaifeng, China. RINGGOLD: 12411 FAU - Zhu, Yuchen AU - Zhu Y AD - Faculty of Education, Henan University, Kaifeng, China]. RINGGOLD: 12411 FAU - Yang, Ke AU - Yang K AD - Student affairs office, Kaifeng Technical College, Kaifeng, China. RINGGOLD: 124172 LA - eng PT - Journal Article DEP - 20250515 PL - United States TA - Psychol Rep JT - Psychological reports JID - 0376475 SB - IM OTO - NOTNLM OT - body image OT - eating disorder OT - sex difference OT - short-form video platform EDAT- 2025/05/15 18:36 MHDA- 2025/05/15 18:36 CRDT- 2025/05/15 16:43 PHST- 2025/05/15 18:36 [medline] PHST- 2025/05/15 18:36 [pubmed] PHST- 2025/05/15 16:43 [entrez] AID - 10.1177/00332941251343534 [doi] PST - aheadofprint SO - Psychol Rep. 2025 May 15:332941251343534. doi: 10.1177/00332941251343534. PMID- 40369866 OWN - NLM STAT- MEDLINE DCOM- 20250729 LR - 20250729 IS - 1097-4598 (Electronic) IS - 0148-639X (Linking) VI - 72 IP - 2 DP - 2025 Aug TI - Nerve Ultrasound for Detecting Morphologic Changes in Malnourished Children Under 5 Years of Age: A Comparative Study of Nutritional Intervention Outcomes in Bangladesh. PG - 258-266 LID - 10.1002/mus.28432 [doi] AB - INTRODUCTION/AIMS: Malnourished children may experience disrupted peripheral nerve myelination, leading to impaired nerve conduction. However, ultrasound data on nerve morphology in severely malnourished children are lacking. Therefore, we performed a systematic study, comparing nerve ultrasound in malnourished children to controls. METHODS: Nerve cross-sectional area (CSA) was assessed in three categories of malnourished (severe acute malnutrition [SAM], stunted, and wasted) and healthy Bangladeshi children aged 6-59 months to compare morphological changes at baseline (pre-intervention) and post-nutritional intervention. RESULTS: A total of 74 children were enrolled, including 17 with SAM, 19 wasted, 18 stunted, and 20 healthy controls. SAM children showed smaller nerve CSA compared to wasted peers, particularly in the sciatic nerve (8.25 mm(2) vs. 11.48 mm(2), p = 0.035) and median nerve proximal wrist (2.65 mm(2) vs. 2.90 mm(2), p = 0.004) among 6-23-month-olds. In the 24-59-month group, the median nerve proximal wrist CSA in SAM children was 2.30 mm(2) versus 3.90 mm(2) in healthy children (p = 0.019), and sciatic nerve CSA was 9.05 mm(2) versus 16.60 mm(2) (p = 0.008). Nutritional intervention improved z-scores in SAM children numerically, though not significantly within the study period. DISCUSSION: SAM children had smaller nerve CSA compared with wasted, stunted, and healthy children at specific nerve locations. These findings underscore the substantial impact of SAM on nerve morphology and the importance of early, sustained nutritional interventions, warranting further validation through animal models and large-scale studies in both children and adults. CI - (c) 2025 Wiley Periodicals LLC. FAU - Naila, Nurun Nahar AU - Naila NN AUID- ORCID: 0000-0002-9694-6217 AD - Nutrition Research Division, ICDDR,B, Dhaka, Bangladesh. FAU - Alam, Aklima AU - Alam A AUID- ORCID: 0000-0002-4686-2584 AD - Nutrition Research Division, ICDDR,B, Dhaka, Bangladesh. FAU - Karmakar, Gobinda AU - Karmakar G AD - Nutrition Research Division, ICDDR,B, Dhaka, Bangladesh. FAU - Islam, M Munirul AU - Islam MM AD - Nutrition Research Division, ICDDR,B, Dhaka, Bangladesh. FAU - Ahmed, Tahmeed AU - Ahmed T AD - Nutrition Research Division, ICDDR,B, Dhaka, Bangladesh. AD - Office of the Executive Director, ICDDR,B, Dhaka, Bangladesh. FAU - Islam, Badrul AU - Islam B AD - BRB Hospitals Limited, Dhaka, Bangladesh. AD - KPJ Specialized Hospital & Nursing College, Dhaka, Bangladesh. LA - eng GR - Mujib 100 Research Grant for Women (MRGW) from Government of Bangladesh/ PT - Comparative Study PT - Journal Article DEP - 20250514 PL - United States TA - Muscle Nerve JT - Muscle & nerve JID - 7803146 SB - IM MH - Humans MH - Infant MH - Bangladesh MH - Male MH - Female MH - Child, Preschool MH - Ultrasonography MH - *Sciatic Nerve/diagnostic imaging MH - *Median Nerve/diagnostic imaging MH - *Child Nutrition Disorders/diagnostic imaging/diet therapy MH - *Severe Acute Malnutrition/diagnostic imaging/diet therapy OTO - NOTNLM OT - Bangladesh OT - children OT - cross-sectional area OT - malnutrition OT - nerve OT - nerve size OT - nutrition intervention OT - severe acute malnutrition OT - ultrasonogram EDAT- 2025/05/15 06:33 MHDA- 2025/07/29 18:31 CRDT- 2025/05/15 01:33 PHST- 2025/04/27 00:00 [revised] PHST- 2024/05/09 00:00 [received] PHST- 2025/04/30 00:00 [accepted] PHST- 2025/07/29 18:31 [medline] PHST- 2025/05/15 06:33 [pubmed] PHST- 2025/05/15 01:33 [entrez] AID - 10.1002/mus.28432 [doi] PST - ppublish SO - Muscle Nerve. 2025 Aug;72(2):258-266. doi: 10.1002/mus.28432. Epub 2025 May 14. PMID- 40369501 OWN - NLM STAT- MEDLINE DCOM- 20250515 LR - 20250517 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 May 14 TI - Validation of a Slovenian version of the Healthy Lifestyle and Personal Control Questionnaire (HLPCQ) for use with patients in family medicine. PG - 1778 LID - 10.1186/s12889-025-22945-4 [doi] LID - 1778 AB - BACKGROUND: Chronic non-communicable diseases are the world's leading cause of death and disability. The emerging field of lifestyle medicine requires equipping healthcare professionals with instruments, knowledge, skills and competencies. Measuring an individual's lifestyle with a valid and reliable instrument is the first step in promoting it. The aim of the study was to validate the Slovenian adaptation of the Healthy Lifestyle and Personal Control Questionnaire (HLPCQ). METHODS: A cross-sectional study was conducted among 666 questionnaire participants, and they were adult participants (aged 18 and above) from family medicine practices with cardiovascular diseases (CVDs) risk factors (e.g., hypertension, high cholesterol) but without a diagnosis of acute CVDs. The questionnaire included demographic data and anthropological measures and a translated English HLPCQ questionnaire. The instrument was translated using the forward-backwards translation method. The study was conducted in accordance with the principles of the World Medical Association Declaration of Helsinki. In addition to assessing the construct validity of the questionnaire, exploratory and confirmatory factor analyses were used to determine content and face validity, and internal consistency reliability. RESULTS: The mean age of male participants was 41.34 (+/- 13.220) years, the mean age of female participants was 40.31 (+/- 11.905) years. The Cronbach's alpha was 0.852, and all questionnaire subscales had positive correlations. Sampling adequacy was confirmed by the Kaiser-Meyer-Olkin (KMO) index (0.851), and Bartlett's test of sphericity was significant (chi(2) = 4647.694, p < 0.001), indicating suitability for Principal Component Analysis (PCA). PCA revealed a five-factor solution, accounting for 50.67% of the total variance. CONCLUSIONS: The most influential factors for a healthy lifestyle were daily routine, healthy dietary choices, avoidance of harmful dietary habits, organized physical activity, and social and mental balance. The Slovenian version had high factor validity and reliability. It can be used in Slovenian Community Health Centre to assess an individual's control over various lifestyle dimensions. The instrument also holds potential for use in public health initiatives, supporting early identification of lifestyle-related risk factors and promoting preventive care strategies in the primary care setting. CI - (c) 2025. The Author(s). FAU - Svensek, Adrijana AU - Svensek A AUID- ORCID: 0000-0003-0323-1720 AD - Faculty of Health Sciences, University of Maribor, Maribor, Slovenia. adrijana.svensek1@um.si. FAU - Stiglic, Gregor AU - Stiglic G AUID- ORCID: 0000-0002-0183-8679 AD - Faculty of Health Sciences, University of Maribor, Maribor, Slovenia. AD - Faculty of Electrical Engineering and Computer Science, University of Maribor, Maribor, Slovenia. AD - Usher Institute, University of Edinburgh, Edinburgh, United Kingdom. FAU - Lorber, Mateja AU - Lorber M AUID- ORCID: 0000-0001-7200-5204 AD - Faculty of Health Sciences, University of Maribor, Maribor, Slovenia. LA - eng PT - Journal Article PT - Validation Study DEP - 20250514 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Male MH - Female MH - Slovenia MH - Adult MH - Surveys and Questionnaires/standards MH - Cross-Sectional Studies MH - Middle Aged MH - Reproducibility of Results MH - *Healthy Lifestyle MH - *Family Practice MH - Cardiovascular Diseases/prevention & control MH - Young Adult MH - Aged MH - Factor Analysis, Statistical MH - Adolescent PMC - PMC12076945 OTO - NOTNLM OT - HLPCQ OT - Health behaviour OT - Lifestyle OT - Public health OT - Questionnaire OT - Validity COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval and consent to participate: Faculty of Health Sciences, University of Maribor (decision number: 02/7K-2023) and Commission of the Republic of Slovenia for Medical Ethics (decision number: 0120-217/2023/4). Consent for publication: not applicable. EDAT- 2025/05/15 00:35 MHDA- 2025/05/15 06:33 PMCR- 2025/05/14 CRDT- 2025/05/14 23:40 PHST- 2023/10/30 00:00 [received] PHST- 2025/04/25 00:00 [accepted] PHST- 2025/05/15 06:33 [medline] PHST- 2025/05/15 00:35 [pubmed] PHST- 2025/05/14 23:40 [entrez] PHST- 2025/05/14 00:00 [pmc-release] AID - 10.1186/s12889-025-22945-4 [pii] AID - 22945 [pii] AID - 10.1186/s12889-025-22945-4 [doi] PST - epublish SO - BMC Public Health. 2025 May 14;25(1):1778. doi: 10.1186/s12889-025-22945-4. PMID- 40362899 OWN - NLM STAT- MEDLINE DCOM- 20250514 LR - 20250915 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 9 DP - 2025 May 5 TI - Are We Meeting the Needs? A Systematic Review of Nutritional Gaps and Growth Outcomes in Children with Multiple Food Allergies. LID - 10.3390/nu17091590 [doi] LID - 1590 AB - BACKGROUND/OBJECTIVES: Food allergies represent a growing public health challenge, showing an alarming increase in prevalence over the past few decades. Children with multiple food allergies face not only allergic reaction risks but also nutritional gaps, affecting diet, nutrition, and growth. This review summarizes the impact on nutrient intake and growth, highlighting key challenges and strategies to improve clinical care. METHODS: The literature search was conducted using a structured search strategy in PubMed up to 31 January, using MeSH terms with Boolean operators (AND, OR) to combine searches (food hypersensitivity AND growth, food hypersensitivity AND nutrition, food hypersensitivity AND micronutrient, food hypersensitivity AND vitamin, food hypersensitivity AND trace element, and soy hypersensitivity) for human studies meeting pre-defined PICOS criteria that simultaneously assessed the reproducibility and validity. RESULTS: Nearly 2000 studies were identified in the literature search, with 31 articles selected for full-text evaluation and 11 articles included in the final review. Dietary restrictions imposed by the need to avoid multiple allergens can lead to a reduced intake of essential nutrients, particularly proteins, calcium, iron, zinc, iodine, folate, vitamin B12, and vitamin D. Children with multiple FAs appear to be at an increased risk of impaired growth, as evidenced by the lower height-for-age, weight-for-age, head-circumference, and weight-for-length Z-scores compared to non-allergic peers. CONCLUSIONS: Evidence from the studies reviewed suggests that children with multiple FAs may be at increased risk for growth impairments and nutritional inadequacies, especially where dietary management does not adequately compensate for nutrient losses, and highlights that tailored dietary counseling is crucial. FAU - Di Cesare, Gianluca AU - Di Cesare G AUID- ORCID: 0009-0006-3948-2379 AD - Department of Pediatrics, Polytechnic University of Marche, 60123 Ancona, Italy. FAU - Carciofi, Annalisa AU - Carciofi A AD - Department of Pediatrics, Polytechnic University of Marche, 60123 Ancona, Italy. FAU - Borgiani, Francesca AU - Borgiani F AD - Department of Pediatrics, Polytechnic University of Marche, 60123 Ancona, Italy. FAU - Cappelletti, Deborah AU - Cappelletti D AUID- ORCID: 0009-0000-7522-3848 AD - Department of Pediatrics and Neonatology, Provincial General Hospital, 62100 Macerata, Italy. FAU - Correani, Alessio AU - Correani A AD - Department of Odontostomatologic and Specialized Clinical Sciences, Polytechnic University of Marche, 60131 Ancona, Italy. FAU - Monachesi, Chiara AU - Monachesi C AD - Department of Pediatrics, Polytechnic University of Marche, 60123 Ancona, Italy. FAU - Gatti, Simona AU - Gatti S AD - Department of Pediatrics, Polytechnic University of Marche, 60123 Ancona, Italy. FAU - Lionetti, Maria Elena AU - Lionetti ME AD - Department of Pediatrics, Polytechnic University of Marche, 60123 Ancona, Italy. LA - eng PT - Journal Article PT - Systematic Review DEP - 20250505 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Micronutrients) SB - IM MH - Humans MH - *Food Hypersensitivity/complications/physiopathology MH - Child MH - *Nutritional Status MH - Child, Preschool MH - Infant MH - Diet MH - Micronutrients MH - *Growth Disorders/etiology MH - Child Nutritional Physiological Phenomena MH - Female MH - *Child Development PMC - PMC12073476 OTO - NOTNLM OT - dietary counseling OT - food hypersensitivity OT - growth impairment OT - nutrients COIS- The authors declare no conflicts of interest. EDAT- 2025/05/14 11:42 MHDA- 2025/05/14 12:41 PMCR- 2025/05/05 CRDT- 2025/05/14 01:13 PHST- 2025/03/31 00:00 [received] PHST- 2025/04/25 00:00 [revised] PHST- 2025/04/30 00:00 [accepted] PHST- 2025/05/14 12:41 [medline] PHST- 2025/05/14 11:42 [pubmed] PHST- 2025/05/14 01:13 [entrez] PHST- 2025/05/05 00:00 [pmc-release] AID - nu17091590 [pii] AID - nutrients-17-01590 [pii] AID - 10.3390/nu17091590 [doi] PST - epublish SO - Nutrients. 2025 May 5;17(9):1590. doi: 10.3390/nu17091590. PMID- 40362892 OWN - NLM STAT- MEDLINE DCOM- 20250514 LR - 20260127 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 9 DP - 2025 May 4 TI - Dietary Patterns and Major Depression: Results from 15,262 Participants (International ALIMENTAL Study). LID - 10.3390/nu17091583 [doi] LID - 1583 AB - BACKGROUND: Different patterns of food consumption may be associated with a differential risk of depression. Differences in dietary patterns between men and women and across different age groups have been reported, but their influence on the risk of depression has not been fully explored. OBJECTIVES: To investigate the associations between dietary patterns and risk of depression across sex and age groups to identify vulnerable subpopulations, which may inform targeted prevention and intervention strategies. METHODS: The ALIMENTAL study was a cross-sectional, online international survey conducted between 2021 and 2023. Dietary data were collected using a validated food frequency questionnaire; depression data were collected using a self-reported validated questionnaire. Principal component analysis (PCA) was applied to identify distinct food consumption patterns. Multivariate analyses were then conducted to assess the associations between these patterns and depression, adjusting for multiple potential confounders. RESULTS: Among 15,262 participants without chronic diseases or current psychotropic treatments, 4923 (32.2%) were classified in the depression group. Among those aged 18-34, the PCA-derived factor of ultra-processed foods consumption was significantly associated with increased risk of depression in both sexes with similar odds ratios (women 1.21, 95% confidence interval (CI): (1.15; 1.27), men 1.21, 95% CI: (1.07-1.18)). In women aged 18-34, the PCA factors for sodas (aOR 1.10, 95% CI: (1.06; 1.95) and canned and frozen foods (aOR 1.10, 95% CI: (1.04; 1.15) were associated with an increased risk of depression. In participants aged 35-54 years, the association between ultra-processed foods and depression was only observed in women (35-54 years: aOR 1.30, 95% CI: (1.20; 1.42), >/=55 years: 1.41, 95% CI: (1.11; 1.79)), with a significant association between a higher adherence to the PCA-derived "healthy diet" factor (e.g., fruits, nuts, green vegetables) and a lower risk of depression (35-54 years: aOR 0.82, 95% CI: (0.75; 0.89), >/=55 years: aOR 0.79, 95% CI: (0.64; 0.97)). CONCLUSIONS: These results show significant differences between men and women and between age groups regarding associations between dietary patterns and the risk of depression. These findings can help better target public health interventions. FAU - Achour, Yannis AU - Achour Y AD - APHM, CEReSS, Research Centre on Health Services and Quality of Life, Hopitaux Universitaires de Marseille, Aix Marseille University, 13005 Marseille, France. AD - APHM, Departement Universitaire de Medecine Generale (DUMG), Aix Marseille University, 13005 Marseille, France. FAU - Lucas, Guillaume AU - Lucas G AD - APHM, CEReSS, Research Centre on Health Services and Quality of Life, Hopitaux Universitaires de Marseille, Aix Marseille University, 13005 Marseille, France. FAU - Iceta, Sylvain AU - Iceta S AUID- ORCID: 0000-0002-0054-1865 AD - Research Center of the Quebec Heart and Lung Institute, Quebec City, QC G1V 4G5, Canada. AD - Department of Psychiatry and Neurosciences, Laval University, Quebec City, QC G1V 0A6, Canada. FAU - Boucekine, Mohamed AU - Boucekine M AD - APHM, CEReSS, Research Centre on Health Services and Quality of Life, Hopitaux Universitaires de Marseille, Aix Marseille University, 13005 Marseille, France. FAU - Rahmati, Masoud AU - Rahmati M AUID- ORCID: 0000-0003-4792-027X AD - APHM, CEReSS, Research Centre on Health Services and Quality of Life, Hopitaux Universitaires de Marseille, Aix Marseille University, 13005 Marseille, France. AD - Fondamental Fondation, 94000 Creteil, France. AD - Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad 6815144316, Iran. AD - Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, Vali-E-Asr University of Rafsanjan, Rafsanjan 7718897111, Iran. FAU - Berk, Michael AU - Berk M AD - School of Medicine, Barwon Health, Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, VIC 3216, Australia. AD - Orygen, National Centre of Excellence in Youth Mental Health, University of Melbourne, Melbourne, VIC 3010, Australia. AD - Florey Institute for Neuroscience and Mental Health, Department of Psychiatry, University of Melbourne, Melbourne, VIC 3084, Australia. FAU - Akbaraly, Tasnime AU - Akbaraly T AD - Desbrest Institute of Epidemiology and Public Health (IDESP), University of Montpellier, INSERM (Institut National de Sante et de la Recherche Medicale), 34090 Montpellier, France. FAU - Aouizerate, Bruno AU - Aouizerate B AUID- ORCID: 0000-0002-7092-7747 AD - Fondamental Fondation, 94000 Creteil, France. AD - Regional Reference Center for the Management and Treatment of Anxiety and Depressive Disorders, Charles Perrens Hospital, 33076 Bordeaux, France. AD - INRAE, Bordeaux INP, NutriNeuro, University of Bordeaux, UMR 1286, 33000 Bordeaux, France. FAU - Capuron, Lucile AU - Capuron L AD - Regional Reference Center for the Management and Treatment of Anxiety and Depressive Disorders, Charles Perrens Hospital, 33076 Bordeaux, France. AD - INRAE, Bordeaux INP, NutriNeuro, University of Bordeaux, UMR 1286, 33000 Bordeaux, France. FAU - Marx, Wolfgang AU - Marx W AUID- ORCID: 0000-0002-8556-8230 AD - School of Medicine, Barwon Health, Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, VIC 3216, Australia. FAU - Lane, Melissa M AU - Lane MM AD - School of Medicine, Barwon Health, Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, VIC 3216, Australia. FAU - Nguyen, Cao Duy AU - Nguyen CD AD - Institute for Global Health Innovations, Duy Tan University, Da Nang 550000, Vietnam. FAU - Do, Huyen AU - Do H AD - Research Institute for Advanced Nursing (RIAN), Dong Nai Technology University, Bien Hoa 810000, Vietnam. AD - Department of Health Policy and Management, College of Health Science, Korea University, Seoul 02841, Republic of Korea. FAU - Tran, Bach Xuan AU - Tran BX AD - Faculty of Public Health, VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi 123080, Vietnam. AD - International Institute for Training and Research (INSTAR), VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi 100000, Vietnam. FAU - Yon, Dong Keon AU - Yon DK AUID- ORCID: 0000-0003-1628-9948 AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul 02448, Republic of Korea. AD - Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul 02447, Republic of Korea. FAU - Boyer, Laurent AU - Boyer L AUID- ORCID: 0000-0003-1229-6622 AD - APHM, CEReSS, Research Centre on Health Services and Quality of Life, Hopitaux Universitaires de Marseille, Aix Marseille University, 13005 Marseille, France. AD - Fondamental Fondation, 94000 Creteil, France. FAU - Fond, Guillaume AU - Fond G AUID- ORCID: 0000-0003-3249-2030 AD - APHM, CEReSS, Research Centre on Health Services and Quality of Life, Hopitaux Universitaires de Marseille, Aix Marseille University, 13005 Marseille, France. AD - Fondamental Fondation, 94000 Creteil, France. LA - eng PT - Journal Article DEP - 20250504 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Male MH - Adult MH - Cross-Sectional Studies MH - Young Adult MH - Middle Aged MH - *Major Depressive Disorder/epidemiology/etiology MH - Adolescent MH - *Diet/statistics & numerical data/adverse effects MH - *Feeding Behavior MH - Risk Factors MH - Aged MH - Diet Surveys MH - Sex Factors PMC - PMC12073559 OTO - NOTNLM OT - depression OT - depressive disorders OT - diet OT - mental health OT - mood OT - nutrition OT - nutritional psychiatry OT - psychiatry COIS- Michael Berk is supported by a NHMRC Leadership 3 Investigator grant (GNT2017131). Guillaume Fond is the cofounder of Origine care. Sylvain Iceta is supported by the Fonds de Recherche en Sante du Quebec (FRQS Junior 1; grant number 312066). SI Conferences: invitations as a speaker for Novo Nordisk, Takeda Canada, Bausch Health Canada. Wolfgang Marx (W.M.) is currently funded by an NHMRC Investigator Grant (#2008971). W.M. is the current president of the International Society for Nutritional Psychiatry Research. W.M. has previously received funding from the Cancer Council Queensland and university grants/fellowships from La Trobe University, Deakin University, University of Queensland, and Bond University. W.M. has received funding and/or has attended events funded by Cobram Estate Pty. Ltd. and Bega Dairy and Drinks Pty Ltd. W.M. has received travel funding from Nutrition Society of Australia. W.M. has received consultancy funding from Nutrition Research Australia and ParachuteBH. W.M. has received speakers honoraria from VitaFoods, The Cancer Council Queensland and the Princess Alexandra Research Foundation. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2025/05/14 11:41 MHDA- 2025/05/14 11:42 PMCR- 2025/05/04 CRDT- 2025/05/14 01:13 PHST- 2025/04/09 00:00 [received] PHST- 2025/04/24 00:00 [revised] PHST- 2025/04/30 00:00 [accepted] PHST- 2025/05/14 11:42 [medline] PHST- 2025/05/14 11:41 [pubmed] PHST- 2025/05/14 01:13 [entrez] PHST- 2025/05/04 00:00 [pmc-release] AID - nu17091583 [pii] AID - nutrients-17-01583 [pii] AID - 10.3390/nu17091583 [doi] PST - epublish SO - Nutrients. 2025 May 4;17(9):1583. doi: 10.3390/nu17091583. PMID- 40362881 OWN - NLM STAT- MEDLINE DCOM- 20250514 LR - 20250516 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 9 DP - 2025 May 2 TI - Estimation of Intake of Fat, Saturated Fatty Acids, and Trans Fatty Acids from Sweet and Salty Snacks Among Children and Adolescents. LID - 10.3390/nu17091572 [doi] LID - 1572 AB - Objectives: The study aimed to assess the intake of total fat, saturated fatty acids (SFAs), and trans fatty acids (TFAs) from sweet and salty snacks among Polish schoolchildren and to evaluate differences by age, gender, and nutritional status. Methods: A cross-sectional study was conducted among 362 pupils aged 10-15 years. Snack consumption was assessed using a validated food frequency questionnaire. Fat content was estimated based on product labels and databases, and the Estimated Daily Intake (EDI) of fats was calculated. Intake levels were compared to dietary recommendations and analyzed by gender, age, and BMI category. Results: The mean fat intake from snacks was 34.5 g/day, covering nearly 47% of the recommended daily intake. Over 12% of students exceeded total fat recommendations, 20% exceeded SFA limits, and more than 30% surpassed the TFA intake threshold. The highest intake of fats was observed among 10-year-olds. Over 60% of students in this age group exceeded the TFA's upper intake level. Girls showed slightly higher intakes of total fat and SFAs than boys, although the differences were not statistically significant. Fat intake was highest among children with overweight or obesity. Conclusions: Snacks are a major contributor to unhealthy fat intake among school-aged children, particularly in the youngest age group and those with excess body weight. Early, targeted nutrition education and regulatory strategies are needed to promote healthier snacking habits and reduce the long-term risk of diet-related non-communicable diseases. FAU - Malczyk, Ewa AU - Malczyk E AUID- ORCID: 0000-0001-5111-2748 AD - Department of Health Sciences and Physical Education, University of Applied Sciences in Nysa, 48-300 Nysa, Poland. FAU - Walkiewicz, Katarzyna Weronika AU - Walkiewicz KW AUID- ORCID: 0000-0002-5168-4444 AD - Department of Internal Diseases Propaedeutics and Emergency Medicine, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, Piekarska 18, 44-902 Bytom, Poland. FAU - Muc-Wierzgon, Malgorzata AU - Muc-Wierzgon M AUID- ORCID: 0000-0001-6562-7072 AD - Department of Internal Diseases Propaedeutics and Emergency Medicine, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, Piekarska 18, 44-902 Bytom, Poland. FAU - Dziegielewska-Gesiak, Sylwia AU - Dziegielewska-Gesiak S AUID- ORCID: 0000-0003-1019-5959 AD - Department of Internal Diseases Propaedeutics and Emergency Medicine, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, Piekarska 18, 44-902 Bytom, Poland. LA - eng PT - Journal Article DEP - 20250502 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Trans Fatty Acids) RN - 0 (Dietary Fats) RN - 0 (Fatty Acids) RN - 0 (Sodium Chloride, Dietary) SB - IM MH - Humans MH - Child MH - *Snacks MH - Female MH - Male MH - Adolescent MH - Cross-Sectional Studies MH - *Trans Fatty Acids/administration & dosage/analysis MH - *Dietary Fats/analysis/administration & dosage MH - *Fatty Acids/administration & dosage/analysis MH - Poland MH - Nutritional Status MH - *Sodium Chloride, Dietary MH - Diet Surveys PMC - PMC12073162 OTO - NOTNLM OT - children and adolescents OT - dietary fat OT - dietary habits OT - saturated fatty acids OT - snack consumption OT - trans fatty acids COIS- The authors declare no conflicts of interest. EDAT- 2025/05/14 11:42 MHDA- 2025/05/14 11:43 PMCR- 2025/05/02 CRDT- 2025/05/14 01:13 PHST- 2025/04/08 00:00 [received] PHST- 2025/04/22 00:00 [revised] PHST- 2025/04/30 00:00 [accepted] PHST- 2025/05/14 11:43 [medline] PHST- 2025/05/14 11:42 [pubmed] PHST- 2025/05/14 01:13 [entrez] PHST- 2025/05/02 00:00 [pmc-release] AID - nu17091572 [pii] AID - nutrients-17-01572 [pii] AID - 10.3390/nu17091572 [doi] PST - epublish SO - Nutrients. 2025 May 2;17(9):1572. doi: 10.3390/nu17091572. PMID- 40362865 OWN - NLM STAT- MEDLINE DCOM- 20250514 LR - 20250516 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 9 DP - 2025 Apr 30 TI - Relative Validity and Reproducibility of a Semi-Quantitative Web-Based Food Frequency Questionnaire for Swiss Adults. LID - 10.3390/nu17091555 [doi] LID - 1555 AB - Background/Objectives: Food frequency questionnaires (FFQs) are widely used in large epidemiological studies to assess diet and elucidate its impacts on health. However, they must be validated in the target population before use. Methods: We assessed the relative validity, reproducibility, and usability of the Swiss eFFQ, a web-based, 83-item food frequency questionnaire, using a convenience sample of 177 adults (53.1% females, aged 18-75 years) from German- and French-speaking regions of Switzerland. The participants completed the Swiss eFFQ twice and kept a 4-day estimated food record (4-d FR). The dietary data were compared for energy, nutrient, and food group intakes by calculating mean group-level bias, performing the Wilcoxon signed-rank test, quartile cross-classification, weighted Cohen's kappa (K(w)), and correlation coefficients. Results: The Swiss eFFQ was highly rated by the participants, with a completion time under 35 min, although it tended to underestimate nutrient and food intake compared to the 4-d FR. For 31 of 36 nutrients, fewer than 10% of the participants were classified in opposite quartiles. The median proportion of subjects classified in the same or adjacent quartile was 74.7% (median K(w): 0.25). The median crude and de-attenuated Spearman correlation coefficients were 0.37 and 0.42 for nutrients and 0.45 and 0.52 for food groups, respectively. The median Spearman and intraclass correlation coefficients for the reproducibility of the Swiss eFFQ were 0.70 and 0.69 for nutrients and 0.70 and 0.61 for food groups, respectively. Conclusions: The Swiss eFFQ was shown to be reproducible and user-friendly, with acceptable accuracy in categorizing study participants based on food intake, and offers several advantages for dietary assessment of Swiss adult populations. FAU - Pannen, Sarah T AU - Pannen ST AD - Division of Chronic Disease Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben 84, 8001 Zurich, Switzerland. AD - Swiss School of Public Health, 8001 Zurich, Switzerland. FAU - Chevillard, Elsa AU - Chevillard E AD - Department of Nutrition and Dietetics, Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland, Rue des Caroubiers 25, 1227 Carouge, Switzerland. FAU - Chatelan, Angeline AU - Chatelan A AUID- ORCID: 0000-0003-4326-4789 AD - Department of Nutrition and Dietetics, Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland, Rue des Caroubiers 25, 1227 Carouge, Switzerland. FAU - Marques-Vidal, Pedro AU - Marques-Vidal P AUID- ORCID: 0000-0002-4548-8500 AD - Department of Medicine, Internal Medicine, Lausanne University Hospital, University of Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland. FAU - Stringhini, Silvia AU - Stringhini S AD - Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland. AD - Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland. AD - School of Population and Public Health, Edwin S.H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, 2206 E Mall, Vancouver, BC V6T 1Z3, Canada. FAU - Vorburger, Robert AU - Vorburger R AUID- ORCID: 0000-0001-9780-0343 AD - Institute of Computational Life Sciences, School of Life Sciences and Facility Management, ZHAW Zurich University of Applied Sciences, Schloss 1, 8820 Wadenswil, Switzerland. FAU - Rohrmann, Sabine AU - Rohrmann S AUID- ORCID: 0000-0002-2215-1200 AD - Division of Chronic Disease Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben 84, 8001 Zurich, Switzerland. AD - Swiss School of Public Health, 8001 Zurich, Switzerland. FAU - Steinemann, Nina AU - Steinemann N AUID- ORCID: 0009-0009-2780-6948 AD - Division of Chronic Disease Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben 84, 8001 Zurich, Switzerland. FAU - Sych, Janice AU - Sych J AUID- ORCID: 0000-0003-4680-9377 AD - Institute of Food and Beverage Innovation, School of Life Sciences and Facility Management, ZHAW Zurich University of Applied Sciences, Gruentalstrasse 14, 8820 Wadenswil, Switzerland. LA - eng PT - Journal Article PT - Validation Study DEP - 20250430 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Adult MH - Male MH - Middle Aged MH - Reproducibility of Results MH - Switzerland MH - Aged MH - Young Adult MH - Adolescent MH - *Internet MH - *Diet Surveys/methods MH - Diet Records MH - Surveys and Questionnaires MH - *Diet MH - Nutrition Assessment PMC - PMC12073886 OTO - NOTNLM OT - dietary assessment OT - food frequency questionnaire OT - relative validity OT - reproducibility OT - usability OT - web-based FFQ COIS- The authors declare no conflicts of interest. EDAT- 2025/05/14 11:42 MHDA- 2025/05/14 12:40 PMCR- 2025/04/30 CRDT- 2025/05/14 01:13 PHST- 2025/03/23 00:00 [received] PHST- 2025/04/25 00:00 [revised] PHST- 2025/04/28 00:00 [accepted] PHST- 2025/05/14 12:40 [medline] PHST- 2025/05/14 11:42 [pubmed] PHST- 2025/05/14 01:13 [entrez] PHST- 2025/04/30 00:00 [pmc-release] AID - nu17091555 [pii] AID - nutrients-17-01555 [pii] AID - 10.3390/nu17091555 [doi] PST - epublish SO - Nutrients. 2025 Apr 30;17(9):1555. doi: 10.3390/nu17091555. PMID- 40362832 OWN - NLM STAT- MEDLINE DCOM- 20250514 LR - 20250617 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 9 DP - 2025 Apr 30 TI - A Food-Based Science, Technology, Engineering, Arts, and Mathematics Learning Program May Improve Preschool Children's Science Knowledge and Language Skills in Rural North Carolina. LID - 10.3390/nu17091523 [doi] LID - 1523 AB - Background/Objectives: Early childhood represents a sensitive period for developing positive dietary preferences and important school readiness skills. However, few evidence-based programs leverage opportunities to support children's development in both areas. Our study aimed to assess the preliminary effects of multi-level, teacher-led More PEAS Please! on Head Start children's (3-5 years old) science knowledge, development of academic language, fruit-and-vegetable (FV) liking, and dietary quality. Methods: In this pilot study, we used a repeated-measure research design to assess child-level outcomes. Trained teachers implemented 16 food-based science-learning activities. We assessed child outcomes using validated measures of science knowledge, academic language, FV liking, and dietary quality (Veggie Meter((R))). We used linear mixed models to examine changes from the baseline to post intervention. Fixed effects included age, sex, and race/ethnicity, while the center was treated as a random effect. Results: A total of 273 children were enrolled in the study. The children were mostly male (51.6%), Black/African American (82.1%) and, on average, 3.94 (SD = 0.70) years old. The children demonstrated significant improvements in science knowledge (T1 M = -0.01, SD = 0.82; T4 M = 0.33, SD = 0.90; 95% CI [0.17, 0.50]; p < 0.001) and vocabulary (T1 M = 14.4, SD = 4.5; T4 M = 16.7, SD = 5.3; 95% CI [1.4, 3.3]; p < 0.001). The children's dietary quality improved from the baseline, but the changes were not significant. Conclusions: The findings suggest that the intervention may support improvements in science knowledge and academic vocabulary among preschool-aged children. We theorize a longer intervention with additional FV exposures may be needed to observe significant dietary changes. Future research should evaluate program effects with a comparison group. FAU - Stage, Virginia C AU - Stage VC AUID- ORCID: 0000-0002-6152-1438 AD - Department of Agricultural & Human Sciences, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, NC 27695, USA. FAU - Dixon, Jocelyn B AU - Dixon JB AUID- ORCID: 0009-0003-6511-7760 AD - Department of Agricultural & Human Sciences, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, NC 27695, USA. FAU - Grist, Pauline AU - Grist P AD - Department of Agricultural & Human Sciences, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, NC 27695, USA. FAU - Wu, Qiang AU - Wu Q AD - Department of Public Health, East Carolina University, Greenville, NC 27834, USA. FAU - Hegde, Archana V AU - Hegde AV AUID- ORCID: 0000-0002-4909-8366 AD - Department of Human Development & Family Science, College of Health and Human Performance, East Carolina University, Greenville, NC 27834, USA. FAU - Lee, Tammy D AU - Lee TD AUID- ORCID: 0000-0002-8084-4953 AD - Department of Mathematics, Science, & Instructional Technology Education, College of Education, East Carolina University, Greenville, NC 27834, USA. FAU - Lundquist, Ryan AU - Lundquist R AD - Department of Agricultural & Human Sciences, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, NC 27695, USA. FAU - Goodell, L Suzanne AU - Goodell LS AD - Department of Food, Bioprocessing and Nutrition Sciences, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, NC 27695, USA. LA - eng GR - R25 GM132939/GM/NIGMS NIH HHS/United States GR - R25GM132939/National Institute of General Medical Sciences of the National Institutes of Health Science Education Partnership Award/ PT - Journal Article DEP - 20250430 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Child, Preschool MH - Female MH - Pilot Projects MH - North Carolina MH - Rural Population MH - *Science/education MH - *Language MH - Learning MH - Health Knowledge, Attitudes, Practice PMC - PMC12074164 OTO - NOTNLM OT - Head Start OT - STEAM OT - Veggie Meter(R) OT - food-based learning OT - intervention OT - preschool OT - science COIS- The authors declare no conflicts of interest. EDAT- 2025/05/14 11:42 MHDA- 2025/05/14 11:43 PMCR- 2025/04/30 CRDT- 2025/05/14 01:13 PHST- 2025/04/15 00:00 [received] PHST- 2025/04/25 00:00 [revised] PHST- 2025/04/28 00:00 [accepted] PHST- 2025/05/14 11:43 [medline] PHST- 2025/05/14 11:42 [pubmed] PHST- 2025/05/14 01:13 [entrez] PHST- 2025/04/30 00:00 [pmc-release] AID - nu17091523 [pii] AID - nutrients-17-01523 [pii] AID - 10.3390/nu17091523 [doi] PST - epublish SO - Nutrients. 2025 Apr 30;17(9):1523. doi: 10.3390/nu17091523. PMID- 40362795 OWN - NLM STAT- MEDLINE DCOM- 20250514 LR - 20250516 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 9 DP - 2025 Apr 28 TI - The Link Between Physical Activity, Nutrition, and Health: A Cross-Sectional Study with Multivariate Analysis in a Young and Predominantly Female Spanish Sample. LID - 10.3390/nu17091486 [doi] LID - 1486 AB - BACKGROUND: Physical activity and nutrition play a crucial role in maintaining overall health and well-being. This cross-sectional study analyzes the relationship between physical activity habits and dietary patterns in the Spanish population. METHODS: Data were collected through validated questionnaires: the Nutritional and Social Healthy Habits scale (NutSo-HH) for nutritional and lifestyle habits and the Global Physical Activity Questionnaire for physical activity distributed via social media from June to November 2024. RESULTS: The sample included 1534 respondents (67% female), aged 18-65+ years, with diverse educational, income, and living conditions. Socio-demographic, nutritional, lifestyle, and physical activity data were analyzed using non-parametric statistical tests and Principal Component Analysis. On average, participants engaged in 96.7 min/week of high-intensity physical activity and 118 min/week) of moderate-intensity physical activity. While 75% met the WHO recommendations for moderate activity, only 40% reached optimal levels of high-intensity activity. Individuals engaging in higher levels of physical activity, particularly high-intensity exercise, reported better self-perceived health, lower obesophobia, and better body image. Additionally, a positive correlation was found between higher physical activity levels and the consumption of fruits, vegetables, legumes, and fish, while individuals with lower physical activity levels demonstrated a higher intake of ultra-processed and fried foods. CONCLUSIONS: The Principal Component Analysis revealed a bidirectional relationship between the alignment of healthy dietary habits and increased physical activity. These findings highlight the importance of promoting both physical activity and balanced nutrition to enhance overall health and lifestyle quality. FAU - Sandri, Elena AU - Sandri E AUID- ORCID: 0000-0001-5770-0719 AD - Faculty of Medicine and Health Sciences, Catholic University of Valencia San Vicente Martir, C/Quevedo 2, 46001 Valencia, Spain. FAU - Capoferri, Michela AU - Capoferri M AD - Department of Animal Production and Health, Veterinary Public Health, and Food Science and Technology, Institute of Biomedical Sciences, Faculty of Veterinary Medicine, Cardenal Herrera-CEU University, Calle Santiago Ramon y Cajal 20, 46115 Alfara del Patriarca, Spain. FAU - Luciani, Gaia AU - Luciani G AUID- ORCID: 0009-0003-8131-1571 AD - Department of Biomedicine and Prevention, Tor Vergata University, Via Montpellier 1, 00133 Rome, Italy. FAU - Piredda, Michela AU - Piredda M AUID- ORCID: 0000-0001-5998-476X AD - Research Unit Nursing Science, Department of Medicine and Surgery, Campus Bio-Medico di Roma University, Via Alvaro del Portillo 21, 00128 Rome, Italy. LA - eng PT - Journal Article DEP - 20250428 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Adult MH - *Exercise/physiology MH - Spain MH - Middle Aged MH - Young Adult MH - Aged MH - Adolescent MH - Male MH - *Nutritional Status MH - *Feeding Behavior MH - Life Style MH - Multivariate Analysis MH - Surveys and Questionnaires MH - Diet MH - Diet, Healthy PMC - PMC12073803 OTO - NOTNLM OT - healthy habits OT - lifestyle habits OT - physical activity OT - socio-demographic factors OT - sport COIS- The authors declare no conflicts of interest. EDAT- 2025/05/14 11:42 MHDA- 2025/05/14 12:41 PMCR- 2025/04/28 CRDT- 2025/05/14 01:13 PHST- 2025/04/08 00:00 [received] PHST- 2025/04/22 00:00 [revised] PHST- 2025/04/26 00:00 [accepted] PHST- 2025/05/14 12:41 [medline] PHST- 2025/05/14 11:42 [pubmed] PHST- 2025/05/14 01:13 [entrez] PHST- 2025/04/28 00:00 [pmc-release] AID - nu17091486 [pii] AID - nutrients-17-01486 [pii] AID - 10.3390/nu17091486 [doi] PST - epublish SO - Nutrients. 2025 Apr 28;17(9):1486. doi: 10.3390/nu17091486. PMID- 40362764 OWN - NLM STAT- MEDLINE DCOM- 20250514 LR - 20250516 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 9 DP - 2025 Apr 26 TI - The Impact of Social Media on Body Image Perception in Young People. LID - 10.3390/nu17091455 [doi] LID - 1455 AB - BACKGROUND: Social media can significantly impact body image perception among adolescents. OBJECTIVE: This study examines how exposure to fitspiration content relates to body esteem, with a focus on gender differences and BMI. METHODS: A cross-sectional online survey was conducted among 211 participants using validated instruments (Body Esteem Scale, A. Sobczak's silhouette scale). Data were analyzed using descriptive statistics and chi-square tests. RESULTS: Exposure to athletic images decreased self-esteem in 37% of participants, particularly among women (p = 0.004). Gender significantly influenced the tendency to compare oneself with athletic individuals (p = 0.02). BMI was not significantly associated with body image perception (p = 0.05). CONCLUSIONS: Gender-specific patterns in social media-related body image perception highlight the need for targeted interventions to mitigate negative impacts among young adults. FAU - Czubaj, Natalia AU - Czubaj N AD - Department of Public Health, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, 41902 Bytom, Poland. FAU - Szymanska, Martyna AU - Szymanska M AD - Department of Public Health, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, 41902 Bytom, Poland. FAU - Nowak, Beata AU - Nowak B AD - Department of Public Health, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, 41902 Bytom, Poland. FAU - Grajek, Mateusz AU - Grajek M AUID- ORCID: 0000-0001-6588-8598 AD - Department of Public Health, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, 41902 Bytom, Poland. LA - eng PT - Journal Article DEP - 20250426 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Social Media MH - *Body Image/psychology MH - Female MH - Male MH - Cross-Sectional Studies MH - Young Adult MH - Adolescent MH - Self Concept MH - Body Mass Index MH - Surveys and Questionnaires MH - Sex Factors MH - Adult PMC - PMC12074223 OTO - NOTNLM OT - body image OT - self concept OT - social media COIS- The authors declare no conflicts of interest. EDAT- 2025/05/14 11:42 MHDA- 2025/05/14 12:39 PMCR- 2025/04/26 CRDT- 2025/05/14 01:13 PHST- 2025/04/10 00:00 [received] PHST- 2025/04/22 00:00 [revised] PHST- 2025/04/25 00:00 [accepted] PHST- 2025/05/14 12:39 [medline] PHST- 2025/05/14 11:42 [pubmed] PHST- 2025/05/14 01:13 [entrez] PHST- 2025/04/26 00:00 [pmc-release] AID - nu17091455 [pii] AID - nutrients-17-01455 [pii] AID - 10.3390/nu17091455 [doi] PST - epublish SO - Nutrients. 2025 Apr 26;17(9):1455. doi: 10.3390/nu17091455. PMID- 40361110 OWN - NLM STAT- MEDLINE DCOM- 20250514 LR - 20260618 IS - 1478-7954 (Electronic) IS - 1478-7954 (Linking) VI - 23 IP - 1 DP - 2025 May 13 TI - Composite anthropometric data quality index for children under the age of 5 on the Brazilian National Food and Nutrition Surveillance System, 2019-2021. PG - 18 LID - 10.1186/s12963-025-00371-3 [doi] LID - 18 AB - BACKGROUND: A composite evaluation that merges various data quality indicators separately enabled the researchers to score the overall data quality of the research. In this context, the objective of the present study is to develop composite anthropometric data quality indices for children under 5 registered on the Brazilian National Food and Nutrition Surveillance System (SISVAN) from 2019 to 2021. METHODS: Anthropometric data quality indicators were generated for 5,210 Brazilian municipalities: coverage, completeness, the ratio between the sexes, age difference index, preference for height and weight digits, biologically implausible z-score values, and standard deviation. Principal component analysis [PCA] was used to generate a composite anthropometric data quality index for standardized height-for-age (HAZ) and weight-for-height z score (WHZ) indices. The municipalities were ranked in descending order, following their anthropometric quality index values: lowest [worst quality] and highest values [best quality]. RESULTS: In total, 29,367,435 records and 8,930,881 children with anthropometric measurement information were identified. The dispersion indicators, the percentage of biologically implausible values [BIV] and the digit preference had the highest factor loadings. We observed that the worst index values were found in municipalities in the country's poorest and most vulnerable regions [North, Northeast, and Central-West]. The correlation between the HAZ and WHZ quality indices was 0.74. CONCLUSION: The proposed index provides a coherent measurement to discriminate municipal anthropometric data quality. CI - (c) 2025. The Author(s). FAU - Oliveira-Santos, Rafaela AU - Oliveira-Santos R AD - School of Nutrition, Federal University of Bahia (UFBA), Salvador, Bahia, Brazil. AD - Centre for Data and Knowledge Integration for Health (CIDACS), Goncalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil. FAU - de Farias Costa, Priscila Ribas AU - de Farias Costa PR AD - School of Nutrition, Federal University of Bahia (UFBA), Salvador, Bahia, Brazil. AD - Centre for Data and Knowledge Integration for Health (CIDACS), Goncalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil. FAU - de Jesus Silva, Natanael AU - de Jesus Silva N AD - Centre for Data and Knowledge Integration for Health (CIDACS), Goncalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil. AD - ISGlobal, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain. FAU - de Mello E Silva, Juliana Freitas AU - de Mello E Silva JF AD - Centre for Data and Knowledge Integration for Health (CIDACS), Goncalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil. FAU - Sacramento, Lais Silva AU - Sacramento LS AD - Centre for Data and Knowledge Integration for Health (CIDACS), Goncalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil. FAU - Kac, Gilberto AU - Kac G AD - Josue de Castro Institute of Nutrition, Nutritional Epidemiology Observatory, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil. FAU - Ribeiro-Silva, Rita de Cassia AU - Ribeiro-Silva RC AD - School of Nutrition, Federal University of Bahia (UFBA), Salvador, Bahia, Brazil. AD - Centre for Data and Knowledge Integration for Health (CIDACS), Goncalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil. FAU - Barreto, Mauricio Lima AU - Barreto ML AD - Centre for Data and Knowledge Integration for Health (CIDACS), Goncalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil. barreto.mauricio@gmail.com. LA - eng GR - BOL0719/2023/Fundacao de Amparo a Pesquisa do Estado da Bahia, Brasil/ GR - OPP1142172/Bill & Melinda Gates Foundation's/ GR - 442948/2019-0/MS-SCTIE-Decit/ CNPq/ GR - 25000.148278/2022-10/Decit/SECTICS/MS/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250513 PL - England TA - Popul Health Metr JT - Population health metrics JID - 101178411 SB - IM MH - Humans MH - Brazil MH - Male MH - Female MH - Child, Preschool MH - *Anthropometry/methods MH - Infant MH - *Data Accuracy MH - *Nutrition Surveys MH - Body Height MH - Body Weight MH - Infant, Newborn MH - Nutritional Status PMC - PMC12076969 OTO - NOTNLM OT - Anthropometric data quality indicators OT - Anthropometric evaluation OT - Children OT - Food and nutrition surveillance system COIS- Declarations. Ethics approval and consent to participate: The project was submitted and approved as an amendment to the "100 Million Brazilian Cohort" study by the Federal University of Bahia, Institute of Collective Health Ethics Committee (CAAE: 41695415.0.0000.5030). Consent for publication: Not applicable. The data were anonymized and de-identified. Competing interests: The authors declare no competing interests. EDAT- 2025/05/14 11:40 MHDA- 2025/05/14 12:40 PMCR- 2025/05/13 CRDT- 2025/05/13 23:43 PHST- 2024/09/17 00:00 [received] PHST- 2025/02/22 00:00 [accepted] PHST- 2025/05/14 12:40 [medline] PHST- 2025/05/14 11:40 [pubmed] PHST- 2025/05/13 23:43 [entrez] PHST- 2025/05/13 00:00 [pmc-release] AID - 10.1186/s12963-025-00371-3 [pii] AID - 371 [pii] AID - 10.1186/s12963-025-00371-3 [doi] PST - epublish SO - Popul Health Metr. 2025 May 13;23(1):18. doi: 10.1186/s12963-025-00371-3. PMID- 40361011 OWN - NLM STAT- MEDLINE DCOM- 20250514 LR - 20251122 IS - 1129-2377 (Electronic) IS - 1129-2369 (Print) IS - 1129-2369 (Linking) VI - 26 IP - 1 DP - 2025 May 13 TI - Burden of migraine among Egyptian people: prevalence and comorbidities. PG - 114 LID - 10.1186/s10194-025-02016-0 [doi] LID - 114 AB - INTRODUCTION: Migraine is a prevalent debilitating neurological illness that stands among the top causes of disability and significantly impacts the quality of life. Migraine-related functional impairment involves physical, emotional, and economic consequences that frequently impact occupational, academic, social, and familial aspects of life. Depression, anxiety, and sleep disturbances are among the most common comorbid conditions associated with migraine. OBJECTIVE: This study aimed to assess the prevalence of migraine among the Egyptian population and associated comorbidities. METHODS: we conducted a cross-sectional study using a validated Arabic self-administered questionnaire distributed to the general population. The questionnaire was used to collect data on sociodemographic characteristics, migraine frequency, characteristic associated disability, insomnia, and psychological factors. Convenience snowball sampling method was utilized. Univariate and multivariate regression analyzes were applied. RESULTS: A total of 2,533 participants were included in the final analysis from five Egyptian regions. Females represent 57%. More than one-half of participants (59.1%) aged 20-30 years. The prevalence of migraine was 20.9%. The most common triggers were sleep disorders (76.9%), followed by perceived noise (65%), and anxiety (59%). Among the participants diagnosed with migraine, 46.7% had a severe disability, 22% had clinical insomnia of moderate severity, 20.5% had severe depression, 29% had severe anxiety, and 20.6% had severe stress. Females, older age, and urban residents were the key predictors of migraine. Lifestyle factors including regular physical activity and good hydration were linked to reduced migraine risk. Comorbid conditions including insomnia, stress, and anxiety significantly impacted migraine severity. CONCLUSION: Our results showed a 20.9% prevalence of migraine, with nearly one-half of cases associated with severe disability, along with comorbidities like depression, anxiety, and insomnia. Female gender, older age, and urban residence are key predictors, while lifestyle factors such as physical exercise and good hydration reduce the risk of migraine. CI - (c) 2025. The Author(s). FAU - Samir, Ahmed Amir AU - Samir AA AUID- ORCID: 0009-0003-3264-031X AD - Faculty of Medicine, Al-Azhar University, Cario, Egypt. ahmedamirsamir58@gmail.com. FAU - Hageen, Ahmed W AU - Hageen AW AD - Faculty of Medicine, Tanta University, Tanta, Gharbia, Egypt. FAU - Elgammal, Ahmed AU - Elgammal A AD - Faculty of Medicine, Tanta University, Tanta, Gharbia, Egypt. FAU - Meshref, Mostafa AU - Meshref M AD - Department of Neurology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. FAU - El-Refaay, Mennatullah A AU - El-Refaay MA AD - Faculty of Medicine, October's 6 University, October's 6, Egypt. FAU - Taalap, Mohamed Medhat AU - Taalap MM AD - Faculty of Medicine, Tanta University, Tanta, Gharbia, Egypt. FAU - Nassef, Ali Elsaeed AU - Nassef AE AD - Faculty of Medicine, Tanta University, Tanta, Gharbia, Egypt. FAU - Bedewe, Rawan Ali AU - Bedewe RA AD - Faculty of Medicine, Alexandria University, Alexandria, Egypt. FAU - Almeldein, Ahmed AU - Almeldein A AD - Faculty of medicine, Assiut University, Assuit, Egypt. FAU - Kabbash, Ibrahim Ali AU - Kabbash IA AD - Faculty of Medicine, Tanta University, Tanta, Gharbia, Egypt. Ibrahim.kabbash@med.tanta.edu.eg. LA - eng PT - Journal Article DEP - 20250513 PL - England TA - J Headache Pain JT - The journal of headache and pain JID - 100940562 RN - Egyptian people SB - IM MH - Humans MH - Egypt/epidemiology MH - Female MH - *Migraine Disorders/epidemiology/psychology MH - Male MH - Adult MH - Prevalence MH - Cross-Sectional Studies MH - Comorbidity MH - Middle Aged MH - Young Adult MH - *Cost of Illness MH - Anxiety/epidemiology MH - Aged MH - Surveys and Questionnaires MH - Adolescent MH - North African People PMC - PMC12070771 OTO - NOTNLM OT - Anxiety OT - Depression OT - Disability OT - Egypt OT - Insomnia OT - Migraine COIS- Declarations. Ethics approval and consent to participate: The Declaration of Helsinki's guiding principles were followed in the conduct of the study. Contribution to this study was voluntary. The participants' identities and confidentiality were maintained during the study, involving data collection and processing. The ethical approval of the study was obtained from the Institutional Review Board (IRB) of the Faculty of Medicine, Tanta University, Tanta, Egypt (Approval number: 36264PR847/9/24). Everyone who participated provided their informed consent electronically before participation once the study's aims were clearly stated. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/05/14 11:40 MHDA- 2025/05/14 12:40 PMCR- 2025/05/13 CRDT- 2025/05/13 23:39 PHST- 2025/03/03 00:00 [received] PHST- 2025/03/27 00:00 [accepted] PHST- 2025/05/14 12:40 [medline] PHST- 2025/05/14 11:40 [pubmed] PHST- 2025/05/13 23:39 [entrez] PHST- 2025/05/13 00:00 [pmc-release] AID - 10.1186/s10194-025-02016-0 [pii] AID - 2016 [pii] AID - 10.1186/s10194-025-02016-0 [doi] PST - epublish SO - J Headache Pain. 2025 May 13;26(1):114. doi: 10.1186/s10194-025-02016-0. PMID- 40360152 OWN - NLM STAT- MEDLINE DCOM- 20250617 LR - 20250617 IS - 1555-0273 (Electronic) IS - 1555-0265 (Linking) VI - 20 IP - 7 DP - 2025 Jul 1 TI - Use of Heart-Rate Variability to Examine Readiness to Perform in Response to Overload and Taper in Swimmers. PG - 918-924 LID - 10.1123/ijspp.2024-0362 [doi] AB - CONTEXT: The lack of consensus on the best approach to assess the fatigue and readiness status of swimmers has led to an increased risk of maladaptation, overtraining, and suboptimal readiness to perform. Subjective athlete monitoring is prominent in swimming but is prone to bias, distortion, and misinterpretation. Heart-rate variability (HRV) has gained attention from swimming practitioners as an objective monitoring tool for assessing physiological status. OBJECTIVES: The aim of the study was to investigate the validity of HRV in detecting changes in physiological status between overload, recovery, and taper training phases in elite swimmers. METHODS: Eleven state- to international-level swimmers were recruited for the study. Retrospective routine HRV, training, and competition data were accessed for 5 months leading into the Tokyo 2020 Olympics national trials. Linear mixed models examined the relationship between training phase, swimming performance, and 3 HRV metrics (average of all normal R-R intervals [AVNN], root mean square of successive R-R intervals [rMSSD], and rMSSD/AVNN). RESULTS: rMSSD/AVNN was significantly higher in overload training compared with regular training (mean difference = 0.020, P = .002; effect size = moderate). No statistical difference was found for rMSSD or AVNN between training phases (P > .05). Descriptive analyses revealed intraindividual and interindividual variability in HRV response to training phase. Successful swimmers reported higher parasympathetic dominance in early taper followed by increased sympathetic activity leading into competition. CONCLUSION: The findings suggest that a ratio measure between parasympathetic tone and modulation may provide a more comprehensive evaluation of an athlete's physiological status compared with a sole parasympathetic modulation or tone marker. Further research is recommended to improve our understanding of the autonomic nervous system's response to overload and taper training phases. FAU - Bulte, Karla R AU - Bulte KR AUID- ORCID: 0009-0006-3363-2284 AD - Victorian Institute of Sport, Melbourne, VIC, Australia. AD - School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia. FAU - Bruce, Lyndell AU - Bruce L AUID- ORCID: 0000-0003-4652-5171 AD - School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia. AD - Centre for Sport Research, Institute of Physical Activity and Nutrition, Deakin University, Geelong, VIC, Australia. FAU - Hammond, Kristal AU - Hammond K AD - Victorian Institute of Sport, Melbourne, VIC, Australia. FAU - Corrigan, Sean L AU - Corrigan SL AUID- ORCID: 0000-0003-1986-854X AD - School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia. FAU - Main, Luana C AU - Main LC AUID- ORCID: 0000-0002-9576-9466 AD - School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia. AD - Institute for Physical Activity and Nutrition Research, Deakin University, Geelong, VIC, Australia. LA - eng PT - Journal Article DEP - 20250513 PL - United States TA - Int J Sports Physiol Perform JT - International journal of sports physiology and performance JID - 101276430 SB - IM MH - Humans MH - *Swimming/physiology MH - *Heart Rate/physiology MH - Male MH - *Physical Conditioning, Human/methods MH - *Athletic Performance/physiology MH - Young Adult MH - Retrospective Studies MH - Female MH - Competitive Behavior/physiology MH - Adolescent MH - Adult OTO - NOTNLM OT - endurance training OT - exercise performance OT - exercise physiology OT - fitness OT - training EDAT- 2025/05/14 11:40 MHDA- 2025/06/17 14:36 CRDT- 2025/05/13 19:43 PHST- 2024/08/25 00:00 [received] PHST- 2025/03/20 00:00 [revised] PHST- 2025/03/23 00:00 [accepted] PHST- 2025/06/17 14:36 [medline] PHST- 2025/05/14 11:40 [pubmed] PHST- 2025/05/13 19:43 [entrez] AID - 10.1123/ijspp.2024-0362 [doi] PST - epublish SO - Int J Sports Physiol Perform. 2025 May 13;20(7):918-924. doi: 10.1123/ijspp.2024-0362. Print 2025 Jul 1. PMID- 40359425 OWN - NLM STAT- MEDLINE DCOM- 20250514 LR - 20261021 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 5 DP - 2025 TI - Age at menarche and its association with preschool BMI among girls in Northern Norway. PG - e0322986 LID - 10.1371/journal.pone.0322986 [doi] LID - e0322986 AB - BACKGROUND: A decreasing age of menarche has been reported across the Western world. Early menarche is associated with unfavorable health outcomes. AIM: The aims of this study were to describe the age at menarche in a general population sample in Norway and the associations between body mass index (BMI) categories at preschool (approximately 6 years of age) and age at menarche. METHODS: We used self-reported age at menarche among girls who participated in the population-based study Fit Futures 1 (FF 2010-2011), mostly born in 1994, to calculate age at menarche. The preschool BMI from health records was divided into BMI categories according to validated cutoffs on the basis of age and sex from the International Obesity Task Force (IOTF). We estimated the effect of preschool BMI on age at menarche via a linear regression model adjusted for socioeconomic status (SES). RESULTS: Among 500 girls with a mean age of 16.5 years (standard deviation (SD) +/- 1.4), 497 (99%) had completed menarche. The mean age at menarche was 13.0 years (SD +/- 1.2). According to the fitted linear regression model, preschool obesity was a statistically significant predictor of age at menarche and was associated with menarche 9.5 months earlier than a normal preschool BMI was. R2 estimated that preschool BMI could explain 3% of the variance in age at menarche. CONCLUSION: The mean age at menarche in Northern Norway was 13.0 (SD +/- 1.2) years, similar to previous Norwegian studies. Childhood obesity was associated with earlier age at menarche. CI - Copyright: (c) 2025 Joakimsen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Joakimsen, Henrik Lykke AU - Joakimsen HL AUID- ORCID: 0000-0002-0031-4961 AD - Tromso Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway. FAU - Brendlien, Astrid AU - Brendlien A AD - Tromso Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway. FAU - Furberg, Anne-Sofie AU - Furberg AS AD - Department of Microbiology and Infection Control, University Hospital of North Norway, Tromso, Norway. AD - Faculty of Health and Social Sciences, Molde University College, Molde, Norway. FAU - Nielsen, Christopher Sivert AU - Nielsen CS AD - Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway. AD - Department of Pain Management and Research, Oslo University Hospital, Oslo, Norway. FAU - Grimnes, Guri AU - Grimnes G AD - Tromso Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway. AD - Division of Internal Medicine, University Hospital of North Norway, Tromso, Norway. FAU - Evensen, Elin Kristin AU - Evensen EK AD - Department of Health and Care Sciences, Faculty of Health Sciences, UiT the Arctic University of Norway, Tromso, Norway. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250513 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Menarche/physiology MH - Female MH - Norway/epidemiology MH - *Body Mass Index MH - Child, Preschool MH - Adolescent MH - Child MH - Age Factors PMC - PMC12074588 COIS- The authors have declared that no competing interests exist. EDAT- 2025/05/13 18:41 MHDA- 2025/05/14 11:42 PMCR- 2025/05/13 CRDT- 2025/05/13 15:43 PHST- 2025/01/28 00:00 [received] PHST- 2025/04/01 00:00 [accepted] PHST- 2025/05/14 11:42 [medline] PHST- 2025/05/13 18:41 [pubmed] PHST- 2025/05/13 15:43 [entrez] PHST- 2025/05/13 00:00 [pmc-release] AID - PONE-D-25-00972 [pii] AID - 10.1371/journal.pone.0322986 [doi] PST - epublish SO - PLoS One. 2025 May 13;20(5):e0322986. doi: 10.1371/journal.pone.0322986. eCollection 2025. PMID- 40358060 OWN - NLM STAT- MEDLINE DCOM- 20250617 LR - 20260509 IS - 1668-3501 (Electronic) IS - 0325-0075 (Linking) VI - 123 IP - 4 DP - 2025 Aug 1 TI - Concurrent validity and reliability of the Pediatric Postural Balance Scale in Chilean preschool and school-aged children with typical development. PG - e202410276 LID - 10.5546/aap.2024-10276.eng [doi] AB - Introduction. The pediatric postural balance scale (PBS) is a valuable clinical tool for assessing postural balance in preschool and school-aged children with typical or atypical development. Objective. To assess the PBS's concurrent validity and inter-rater reliability in Chilean preschoolers and schoolchildren with typical development. Population and methods. Two hundred and three preschool and school children aged 4 to 11 (7.6 +/- 2.1 years, 56.2% males) from public and private schools participated in a cross-sectional validation study. Postural balance was evaluated with PBS and postural oscillography, considering maximum lateral velocity (MLV), maximum anteroposterior velocity (MAPV), mean total velocity (MTV), mean radius (MR), and center of pressure area (COP area). Anthropometric parameters and socioeconomic level were measured. Results. The inter-rater reliability for the PBS with the intraclass correlation coefficient was 0.99 (95%CI: 0.990-0.997). There were weak inverse correlations between PBS total score and oscillography (MLV, MAPV, MTV, MR, and COP area) in the 4- to 6-year age group, standing out the correlations of mean radius (rho: -0.36; p 0.002) and COP area (Rho: -0.37; p 0.001). Conclusion. These results suggest that the PBS provides a very strong inter-rater reliability and a weak inverse correlation between the PBS total score and postural oscillography measures in the 4- to 6-yearold age group. Therefore, using PBS is recommended primarily in preschoolers and school children between 4 and 6 years of age. CI - Sociedad Argentina de Pediatria. FAU - Vanneste-Fierro, Stephanie AU - Vanneste-Fierro S AD - Kinesiology Career, Faculty of Health Sciences, Universidad Autonoma de Chile, Temuco, Chile. FAU - Barramuno, Mauricio AU - Barramuno M AD - Kinesiology Career, Faculty of Health Sciences, Universidad Autonoma de Chile, Temuco, Chile. AD - School of Kinesiology, Faculty of Health, Universidad Santo Tomas, Chile. FAU - Andrade-Mayorga, Omar AU - Andrade-Mayorga O AUID- ORCID: 0000-0003-3359-4100 AD - Department of Preclinical Sciences, Faculty of Medicine, Universidad de La Frontera, Temuco, Chile. AD - Center for Research in Cardiometabolic and Nutritional Epidemiology (EPICYN, by its Spanish acronym), Faculty of Medicine, Universidad de La Frontera, Chile. FAU - Lavados-Romo, Pamela AU - Lavados-Romo P AUID- ORCID: 0000-0002-6799-798X AD - Department of Preclinical Sciences, Faculty of Medicine, Universidad de La Frontera, Temuco, Chile. AD - Center for Research in Cardiometabolic and Nutritional Epidemiology (EPICYN, by its Spanish acronym), Faculty of Medicine, Universidad de La Frontera, Chile. LA - eng LA - spa PT - Journal Article PT - Validation Study TT - Validez concurrente y confiabilidad de la escala de equilibrio postural pediatrico en preescolares y escolares chilenos con desarrollo tipico. PL - Argentina TA - Arch Argent Pediatr JT - Archivos argentinos de pediatria JID - 0372460 SB - IM MH - Humans MH - *Postural Balance/physiology MH - Chile MH - Male MH - Cross-Sectional Studies MH - Child, Preschool MH - Child MH - Female MH - Reproducibility of Results MH - *Child Development/physiology OTO - NOTNLM OT - child OT - postural balance OT - validation study EDAT- 2025/05/13 13:50 MHDA- 2025/06/17 18:26 CRDT- 2025/05/13 08:25 PHST- 2025/06/17 18:26 [medline] PHST- 2025/05/13 13:50 [pubmed] PHST- 2025/05/13 08:25 [entrez] AID - 10.5546/aap.2024-10276.eng [doi] PST - ppublish SO - Arch Argent Pediatr. 2025 Aug 1;123(4):e202410276. doi: 10.5546/aap.2024-10276.eng. PMID- 40357673 OWN - NLM STAT- MEDLINE DCOM- 20250520 LR - 20260825 IS - 2047-9980 (Electronic) IS - 2047-9980 (Linking) VI - 14 IP - 10 DP - 2025 May 20 TI - Patient-Reported Social Determinants of Health in Patients With Heart Failure. PG - e041458 LID - 10.1161/JAHA.124.041458 [doi] LID - e041458 AB - BACKGROUND: Social determinants of health (SDOH) complicate medical care and affect clinical outcomes, but the lack of a reliable structured interview for medical patients has impeded clinical assessment and research on SDOH. We assessed the reliability and validity of a newly developed SDOH Patient Interview Form and investigated SDOH in patients with heart failure. METHODS: The SDOH Patient Interview Form was administered to recently hospitalized patients with heart failure between January 2021 and April 2024. The interviews were recorded, and 50 were randomly selected for the interrater reliability analysis. RESULTS: The sample included 367 participants (mean age, 61.2+/-12.1 years; 42.5% women; 57.7% minorities). The interrater reliability of SDOH Patient Interview Form categories (eg, Legal and Social Problems) was 100%. The kappa reliability coefficients for individual items were >/=0.94. Higher lifetime SDOH counts were associated with lower age and income and higher New York Heart Association class and body mass index. Two distinct sets of problems were found to contribute to relatively high burdens of SDOH. The first originates with abuse in childhood and presents as severe socioeconomic deprivation in adulthood. The second includes losses of family members and occupational, financial, and caregiver stress along with difficulty affording medical care. CONCLUSIONS: The SDOH Patient Interview Form is a reliable instrument for assessing patient-reported SDOH in patients with heart failure. It is suitable for use in research and clinical contexts but requires further testing in other medical patient populations. This study revealed 2 distinct patterns of stressful problems that can contribute to a high overall burden of SDOH. REGISTRATION: URL: https://clinicaltrials.gov; Unique identifier: NCT04637776. FAU - Freedland, Kenneth E AU - Freedland KE AUID- ORCID: 0000-0002-3118-9913 AD - Washington University School of Medicine St. Louis MO USA. FAU - Steinmeyer, Brian C AU - Steinmeyer BC AD - Washington University School of Medicine St. Louis MO USA. FAU - Skala, Judith A AU - Skala JA AUID- ORCID: 0000-0001-7779-5030 AD - Washington University School of Medicine St. Louis MO USA. FAU - Carney, Robert M AU - Carney RM AD - Washington University School of Medicine St. Louis MO USA. FAU - Rich, Michael W AU - Rich MW AUID- ORCID: 0000-0002-4243-9391 AD - Washington University School of Medicine St. Louis MO USA. LA - eng SI - ClinicalTrials.gov/NCT04637776 GR - R01 HL151431/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Observational Study PT - Research Support, N.I.H., Extramural DEP - 20250513 PL - England TA - J Am Heart Assoc JT - Journal of the American Heart Association JID - 101580524 SB - IM MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - *Heart Failure/psychology/therapy/epidemiology/diagnosis MH - Patient Reported Outcome Measures MH - Reproducibility of Results MH - *Social Determinants of Health MH - Socioeconomic Factors PMC - PMC12184543 OTO - NOTNLM OT - heart failure OT - reproducibility of results OT - self-report OT - social determinants of health COIS- None. EDAT- 2025/05/13 06:33 MHDA- 2025/05/20 17:06 PMCR- 2025/05/13 CRDT- 2025/05/13 05:53 PHST- 2025/05/20 17:06 [medline] PHST- 2025/05/13 06:33 [pubmed] PHST- 2025/05/13 05:53 [entrez] PHST- 2025/05/13 00:00 [pmc-release] AID - JAH310950 [pii] AID - 10.1161/JAHA.124.041458 [doi] PST - ppublish SO - J Am Heart Assoc. 2025 May 20;14(10):e041458. doi: 10.1161/JAHA.124.041458. Epub 2025 May 13. PMID- 40357266 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250514 IS - 2673-6217 (Electronic) IS - 2673-6217 (Print) IS - 2673-6217 (Linking) VI - 6 DP - 2025 TI - The impact of age and frailty on hospitalization and survival in older liver transplant recipients: a longitudinal cohort study. PG - 1539688 LID - 10.3389/fragi.2025.1539688 [doi] LID - 1539688 AB - PURPOSE: Frailty is a well-established risk factor for adverse outcomes, particularly in liver transplant candidates. This study investigates the impact of age and frailty on key clinical outcomes-hospitalizations, waitlist survival, and post-transplant mortality-in cirrhotic patients evaluated for liver transplantation. METHODS: This study included older adults with chronic liver disease under consideration for transplantation. Data collected encompassed medical history, Model for End-Stage Liver Disease (MELD) and Child-Turcotte-Pugh (CTP) scores, Mini-Mental State Examination (MMSE), Mini Nutritional Assessment (MNA), and frailty status, assessed using both the Liver Frailty Index (LFI) and the Survey of Health, Ageing, and Retirement in Europe Frailty Index (SHARE-FI). Clinical outcomes, including mortality and hospitalizations, were tracked over a 24-month period. RESULTS: Among 100 patients (67% male), those under 70 exhibited higher MNA, MMSE, and SHARE-FI scores. Based on frailty classification, 25 patients were frail, 28 pre-frail, and 47 robust. Younger patients experienced more hospitalizations during follow-up (p = 0.03) and had a higher probability of hospitalization within 24 months (p = 0.002). Although transplant-free survival did not differ significantly across groups, frail patients had a significantly higher mortality rate (p = 0.04). Overall, 24 patients underwent transplantation, while 26 died, including six post-transplant deaths. MELD and CTP scores were strong predictors of mortality, while among frailty measures, only SHARE-FI demonstrated significant predictive value. In multivariate Cox models, MELD [HR = 1.17, p = 0.001; HR = 1.11, p = 0.002], CTP [HR = 1.43, p = 0.003; HR = 1.41, p = 0.006], and LFI (HR = 1.69, p = 0.04) were significantly associated with mortality. CONCLUSION: Frailty, rather than age, emerges as a key predictor of mortality in liver transplant candidates. Further research is needed to validate these findings and enhance frailty assessment, ultimately improving candidate selection for transplantation. CI - Copyright (c) 2025 Valenti, Ceolin, Rossato, Curreri, Devita, Tonon, Campodall'Orto, Vanin, Gambato, Cillo, Burra, Angeli, Sergi and De Rui. FAU - Valenti, Matteo AU - Valenti M AD - Department of Medicine - DIMED, University of Padua, Italy. AD - Division of Geriatrics, DIDAS Medicine Department, University - Hospital of Padua, Padua, Italy. FAU - Ceolin, Chiara AU - Ceolin C AD - Department of Medicine - DIMED, University of Padua, Italy. AD - Division of Geriatrics, DIDAS Medicine Department, University - Hospital of Padua, Padua, Italy. AD - Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Aging Research Center, Stockholm, Sweden. FAU - Rossato, Marco AU - Rossato M AD - Department of Medicine - DIMED, University of Padua, Italy. AD - Division of Geriatrics, DIDAS Medicine Department, University - Hospital of Padua, Padua, Italy. FAU - Curreri, Chiara AU - Curreri C AD - Department of Medicine - DIMED, University of Padua, Italy. AD - Division of Geriatrics, DIDAS Medicine Department, University - Hospital of Padua, Padua, Italy. FAU - Devita, Maria AU - Devita M AD - Department of Medicine - DIMED, University of Padua, Italy. AD - Department of General Psychology - DPG, University of Padua, Italy. FAU - Tonon, Marta AU - Tonon M AD - Department of Medicine - DIMED, University of Padua, Italy. AD - Division of Hepatobiliary Surgery and Liver Transplantation, DIDAS Surgery Department, University - Hospital of Padua, Padua, Italy. FAU - Campodall'Orto, Carlotta AU - Campodall'Orto C AD - Division of Geriatrics, DIDAS Medicine Department, University - Hospital of Padua, Padua, Italy. FAU - Vanin, Jessica AU - Vanin J AD - Division of Geriatrics, DIDAS Medicine Department, University - Hospital of Padua, Padua, Italy. FAU - Gambato, Martina AU - Gambato M AD - Multivisceral Transplant Unit, DIDAS Medicine Department, University - Hospital of Padua, Padua, Italy, University of Padova, Padua, Italy. FAU - Cillo, Umberto AU - Cillo U AD - Division of Hepatobiliary Surgery and Liver Transplantation, DIDAS Surgery Department, University - Hospital of Padua, Padua, Italy. AD - Department of Surgery, Oncology and Gastroenterology - DISCOG, University of Padua, Italy. FAU - Burra, Patrizia AU - Burra P AD - Department of Surgery, Oncology and Gastroenterology - DISCOG, University of Padua, Italy. AD - Gastroenterological Endoscopy Unit, DIDAS Medicine Department, University - Hospital of Padua, Padua, Italy. FAU - Angeli, Paolo AU - Angeli P AD - Department of Medicine - DIMED, University of Padua, Italy. AD - Division of Hepatobiliary Surgery and Liver Transplantation, DIDAS Surgery Department, University - Hospital of Padua, Padua, Italy. FAU - Sergi, Giuseppe AU - Sergi G AD - Department of Medicine - DIMED, University of Padua, Italy. AD - Division of Geriatrics, DIDAS Medicine Department, University - Hospital of Padua, Padua, Italy. FAU - De Rui, Marina AU - De Rui M AD - Department of Medicine - DIMED, University of Padua, Italy. AD - Division of Geriatrics, DIDAS Medicine Department, University - Hospital of Padua, Padua, Italy. LA - eng PT - Journal Article DEP - 20250428 PL - Switzerland TA - Front Aging JT - Frontiers in aging JID - 9918231199706676 PMC - PMC12066423 OTO - NOTNLM OT - CTP OT - MELD OT - frailty OT - liver transplantation OT - older adults COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/05/13 06:33 MHDA- 2025/05/13 06:34 PMCR- 2025/04/28 CRDT- 2025/05/13 04:53 PHST- 2024/12/04 00:00 [received] PHST- 2025/03/28 00:00 [accepted] PHST- 2025/05/13 06:34 [medline] PHST- 2025/05/13 06:33 [pubmed] PHST- 2025/05/13 04:53 [entrez] PHST- 2025/04/28 00:00 [pmc-release] AID - 1539688 [pii] AID - 10.3389/fragi.2025.1539688 [doi] PST - epublish SO - Front Aging. 2025 Apr 28;6:1539688. doi: 10.3389/fragi.2025.1539688. eCollection 2025. PMID- 40356452 OWN - NLM STAT- MEDLINE DCOM- 20250513 LR - 20250515 IS - 2162-3279 (Electronic) VI - 15 IP - 5 DP - 2025 May TI - Advancing Nutritional Status Classification With Hybrid Artificial Intelligence: A Novel Methodological Approach. PG - e70548 LID - 10.1002/brb3.70548 [doi] LID - e70548 AB - PURPOSE: Malnutrition remains a critical public health issue in low-income countries, significantly hindering economic development and contributing to over 50% of infant deaths. Under nutrition weakens immune systems, increasing susceptibility to common illnesses and prolonging recovery periods. This study aims to develop and evaluate a novel artificial intelligence-based classification method for nutritional status assessment using hybrid machine learning strategies, enhancing the accuracy and reliability of malnutrition detection. METHOD: This study utilizes the fire hawk optimizer-based k-means (FHO-K-Means) clustering method to identify key physiological indicators associated with under nutrition in children. The analysis is conducted using the UNICEF dataset, encompassing data from Afghanistan, Albania, Algeria, and Zimbabwe. Following data normalization, the dataset is clustered via FHO-K-Means to establish optimal groupings. The clustered data is then partitioned into training and testing sets for classification using the extreme gradient boosting fuzzy (EGBF). The EGBF model is employed to classify nutritional states, including stunting, wasting, severe wasting, overweight, and underweight, providing a robust framework for predictive analysis. FINDINGS: The proposed FHO-K-Means and EGBF model demonstrated superior performance, achieving 99.84% accuracy, 99.5% precision, 99.8% specificity, and 100% sensitivity, with an F1 measure of 98.6% and a mean squared error (MSE) of 0.01%, outperforming existing classification techniques. These results indicate that the model offers a highly effective and scalable tool for identifying at-risk populations, informing targeted interventions to reduce the prevalence of childhood malnutrition, and lowering morbidity in poor countries. CONCLUSION: This study developed an innovative FHO-K mean clustering and EGBF classification method for assessing childhood nutritional status in underdeveloped countries. The exceptional accuracy and predictive capability of the model make it a valuable tool for early malnutrition detection, enabling data-driven decision-making in public health and policy formulation. By improving malnutrition diagnosis and intervention strategies, this approach has the potential to reduce morbidity and enhance child health outcomes in resource-constrained settings. CI - (c) 2025 The Author(s). Brain and Behavior published by Wiley Periodicals LLC. FAU - Alam, Md Moddassir AU - Alam MM AD - Department of Health Information Management and Technology, College of Applied Medical Sciences, University of Hafr Al Batin, Hafr Al Batin, Saudi Arabia. FAU - Khan, Asif Irshad AU - Khan AI AD - Department of Computer Science, Aligarh Muslim University, Aligarh, India. FAU - Zafar, Aasim AU - Zafar A AD - Department of Computer Science, Aligarh Muslim University, Aligarh, India. FAU - Sohail, Mohammad AU - Sohail M AD - Data Architect and AI/ML Engineer, Hewlett Packard Enterprise, Pennsylvania, USA. FAU - Ahmad, Mohammad Tauheed AU - Ahmad MT AUID- ORCID: 0000-0003-1967-1691 AD - College of Medicine, King Khalid University, Abha, Saudi Arabia. FAU - Azim, Rezaul AU - Azim R AD - Faculty of Science, University of Chittagong, Chittagong, Bangladesh. LA - eng PT - Journal Article PL - United States TA - Brain Behav JT - Brain and behavior JID - 101570837 SB - IM MH - Humans MH - *Nutritional Status/physiology MH - *Artificial Intelligence MH - Infant MH - *Malnutrition/diagnosis/classification MH - Child, Preschool MH - Machine Learning MH - Male MH - Child MH - Cluster Analysis MH - Nutrition Assessment MH - Female PMC - PMC12069982 OTO - NOTNLM OT - child malnutrition OT - children OT - clustering analysis OT - hybrid AI strategies OT - hybrid model OT - machine learning in nutrition OT - malnutrition detection OT - nutritional status analysis COIS- The authors declare no conflicts of interests. EDAT- 2025/05/13 06:33 MHDA- 2025/05/13 06:34 PMCR- 2025/05/13 CRDT- 2025/05/13 03:44 PHST- 2025/05/13 06:34 [medline] PHST- 2025/05/13 06:33 [pubmed] PHST- 2025/05/13 03:44 [entrez] PHST- 2025/05/13 00:00 [pmc-release] AID - BRB370548 [pii] AID - 10.1002/brb3.70548 [doi] PST - ppublish SO - Brain Behav. 2025 May;15(5):e70548. doi: 10.1002/brb3.70548. PMID- 40355120 OWN - NLM STAT- MEDLINE DCOM- 20260209 LR - 20260514 IS - 1098-8785 (Electronic) IS - 0735-1631 (Linking) VI - 43 IP - 3 DP - 2026 Feb TI - A Novel and Modern Calculator to Predict Vaginal Birth after Cesarean Delivery. PG - 300-306 LID - 10.1055/a-2605-7786 [doi] AB - Counseling patients who are considering a trial of labor after cesarean (TOLAC) is a challenging task given the risks and benefits of either approach. While calculators exist to give patients an idea of their likelihood of having a successful vaginal birth after cesarean (VBAC), their validity is limited by outdated mathematical methods used to develop them. Most importantly, current VBAC calculators only offer insight into the chance of successful VBAC, without any ability to predict the risk of adverse outcomes relevant to both the patient and neonate. The objective of this study is to develop a prediction model for individualized risks and benefits of a TOLAC using modern mathematical techniques.This was a secondary analysis of the Cesarean Registry database, the same database used in developing the Maternal-Fetal Medicine Units (MFMU) VBAC calculator. The primary outcome was the prediction of the success of VBAC. Secondary outcomes were the prediction of uterine rupture, maternal complications, and neonatal complications. Inclusion criteria were term, singleton gestation, and cephalic presentation pregnancies with one prior low transverse cesarean delivery (CD). Exclusion criteria included intrauterine fetal demise, planned cesarean, and prior myomectomy. Univariate comparisons identified variables that were independently associated with VBAC. An optimal decision tree was used to create a prediction model. A test set was withheld for validation. A risk calculator tool was developed for the prediction of successful VBAC and adverse perinatal outcomes. Adverse maternal outcomes: uterine dehiscence, hysterectomy, postpartum hemorrhage, endometritis, intensive care unit admission, thromboembolic event, readmission, and organ injury. Adverse neonatal outcomes: hypoxic-ischemic encephalopathy, respiratory distress, seizures, apnea, respirator use, death, and cord blood pH < 7.1.The study population included 73,262 deliveries of which 12,942 patients met inclusion and exclusion criteria. After removing cases for the test set, the included patients were 8,078 patients, of which 5,970 people had a successful VBAC (73.9%). Parity, number of years since prior CD, prepregnancy body mass index (BMI), delivery BMI, maternal age, and previous VBAC were associated with successful VBAC. A risk predictor calculator was created, and a receiver operator characteristic curve was developed with an area under the curve of 0.72. The tool was also developed to identify a person's risk of uterine rupture, composite maternal morbidity, and neonatal morbidity.VBAC for patients with term, cephalic, singleton gestation was associated with several variables. This advanced calculator tool will facilitate shared decision-making about the value of a TOLAC regarding the personalized risks of maternal and neonatal morbidity. By using more advanced mathematical models, this tool allows providers to predict not only the likelihood of successful VBAC but also the risk of maternal and neonatal morbidity involved in attempting VBAC. . Current VBAC calculators are limited by the mathematical methods used to make them.. . This novel calculator uses more advanced machine-learning methods than previous calculators.. . This VBAC calculator predicts both the chance of success VBAC and the risk of morbidity.. . The more modern VBAC calculator gives providers more information to use when counseling patients.. CI - Thieme. All rights reserved. FAU - Gimovsky, Alexis C AU - Gimovsky AC AUID- ORCID: 0000-0002-9358-8995 AD - Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Women & Infants Hospital of Rhode Island, Providence, Rhode Island. FAU - Monje, Silas AU - Monje S AUID- ORCID: 0000-0003-1479-6196 AD - Warren Alpert Medical School, Brown University, Providence, Rhode Island. FAU - Dunn, Jack AU - Dunn J AD - Dynamic Sky, Providence, Rhode Island. FAU - Levine, Jordan AU - Levine J AD - Dynamic Sky, Providence, Rhode Island. LA - eng PT - Journal Article DEP - 20250512 PL - United States TA - Am J Perinatol JT - American journal of perinatology JID - 8405212 SB - IM MH - Humans MH - Female MH - *Vaginal Birth after Cesarean/statistics & numerical data/adverse effects MH - Pregnancy MH - Adult MH - *Trial of Labor MH - Risk Assessment/methods MH - Infant, Newborn MH - Uterine Rupture/epidemiology MH - ROC Curve MH - Registries COIS- None declared. EDAT- 2025/05/13 00:33 MHDA- 2026/02/10 01:29 CRDT- 2025/05/12 20:03 PHST- 2026/02/10 01:29 [medline] PHST- 2025/05/13 00:33 [pubmed] PHST- 2025/05/12 20:03 [entrez] AID - 10.1055/a-2605-7786 [doi] PST - ppublish SO - Am J Perinatol. 2026 Feb;43(3):300-306. doi: 10.1055/a-2605-7786. Epub 2025 May 12. PMID- 40354865 OWN - NLM STAT- MEDLINE DCOM- 20250526 LR - 20260704 IS - 1878-5476 (Electronic) IS - 1878-5476 (Linking) VI - 79 DP - 2025 Jul TI - The Avengers in action: A gamified-based intermittent teaching unit in the Physical Education setting to promote physical activity and its psychological mediators in secondary education students. PG - 102871 LID - S1469-0292(25)00070-6 [pii] LID - 10.1016/j.psychsport.2025.102871 [doi] AB - The purpose of the present study was to examine the effects of a gamified-based intermittent teaching unit in the Physical Education setting, combined with behavior modification strategies and following an autonomy-supportive teaching style, on secondary education students' physical activity (PA) psychological mediators and objective weekly PA levels. A sample of 142 secondary education students (50 % females; 14-16 years) from six classes were clustered randomly and assigned to Avengers (n = 79) or Control (n = 63) groups. The Avengers group students performed a gamified-based intermittent teaching unit using only the first 15 min of each session twice a week for eight weeks. Based on the Trans-Contextual Model of autonomous motivation in education, the intermittent teaching unit was performed by behavior modification strategies such as goal-setting, activity wristband, educational counselling, reminders, diary, motivational messages, and incentives. Students' self-reported PA psychological mediators were assessed by validated psychometric questionnaires before and after the intervention. Moreover, objective weekly PA was assessed by the students wearing a Xiaomi Mi Band 5 activity wristband before and during the last week of the intervention. The Multilevel Linear Model results showed that the gamified-based teaching unit produced a statistically significant improvement in all Avengers group students' PA psychological mediators (p < 0.05; d = 0.29-1.52) and objective weekly PA levels (p < 0.001; d = 1.17). A gamified-based intermittent teaching unit in Physical Education combined with behavior modification strategies seems to be effective for enhancing secondary education students' PA psychological mediators and weekly PA levels. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - Becerra-Fernandez, Carlos A AU - Becerra-Fernandez CA AD - Departamento de Didactica de las Lenguas, las Artes y el Deporte, Facultad de Ciencias de la Educacion, Universidad de Malaga, Malaga, Spain. Electronic address: carlossbecerra@gmail.com. FAU - Guijarro-Romero, Santiago AU - Guijarro-Romero S AD - Department of Physical Education, Sport and Human Movement, Autonomous University of Madrid, Madrid, Spain. Electronic address: santiago.guijarro@uam.es. FAU - Mayorga-Vega, Daniel AU - Mayorga-Vega D AD - Departamento de Didactica de las Lenguas, las Artes y el Deporte, Facultad de Ciencias de la Educacion, Universidad de Malaga, Malaga, Spain. Electronic address: dmayorgavega@uma.es. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20250510 PL - Netherlands TA - Psychol Sport Exerc JT - Psychology of sport and exercise JID - 101088724 SB - IM MH - Humans MH - Female MH - Male MH - Adolescent MH - *Exercise/psychology MH - *Physical Education and Training/methods MH - *Students/psychology MH - Motivation MH - *Health Promotion/methods OTO - NOTNLM OT - Daily steps OT - Gamification OT - High school students OT - Innovative teaching unit OT - Trans-contextual model OT - Wrist-worn wearables COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/05/13 00:33 MHDA- 2025/05/27 00:28 CRDT- 2025/05/12 19:30 PHST- 2024/11/27 00:00 [received] PHST- 2025/05/07 00:00 [revised] PHST- 2025/05/08 00:00 [accepted] PHST- 2025/05/27 00:28 [medline] PHST- 2025/05/13 00:33 [pubmed] PHST- 2025/05/12 19:30 [entrez] AID - S1469-0292(25)00070-6 [pii] AID - 10.1016/j.psychsport.2025.102871 [doi] PST - ppublish SO - Psychol Sport Exerc. 2025 Jul;79:102871. doi: 10.1016/j.psychsport.2025.102871. Epub 2025 May 10. PMID- 40354649 OWN - NLM STAT- MEDLINE DCOM- 20250513 LR - 20260704 IS - 2369-2960 (Electronic) IS - 2369-2960 (Linking) VI - 11 DP - 2025 May 12 TI - Peer Relationships Are a Direct Cause of the Adolescent Mental Health Crisis: Interpretable Machine Learning Analysis of 2 Large Cohort Studies. PG - e60125 LID - 10.2196/60125 [doi] LID - e60125 AB - BACKGROUND: Converging evidence indicates an adolescent mental health crisis in Western societies that has developed and exacerbated over the past decade. The proposed driving factors of this trend include more screen time, physical inactivity, and social isolation, but their causal influence on mental health is insufficiently understood. OBJECTIVE: The objective of this study is to test whether and based on which predictor variables the development of mental health in adolescents in the last decade can be predicted and to better understand the causal chain of factors at work. METHODS: We implemented an interpretable machine learning pipeline based on gradient boosting regression with repeated cross-validation to assess the development of mental health throughout adolescence in members of 2 longitudinal cohort studies, the British Millenium cohort (MC; n=8599) and the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) cohort (n=1212). In total, 144 (MC) and 102 (KiGGS) predictors assessed at the age of around 13.8 years (MC) and 11.6 years (KiGGS) were used to assess mental health at the ages of around 16.7 years (MC) and 16.4 years (KiGGS). Based on these predictive models, we used permutation-based feature importance analyses to identify relevant predictors and predictor domains. Moreover, we performed partial dependence analyses in a causal inference framework to determine the direct effects of physical inactivity, screen time, and peer problems on the development of mental health. RESULTS: The average cross-validated Pearson correlation coefficient (r) between predicted and true mental health in late adolescence was 0.614 (MC) and 0.466 (KiGGS). Feature importance analyses indicated a strong impact of preexisting mental health and weaker impacts of sex (female as a risk factor), physical health (chronic disease as a risk factor), lifestyle, and socioeconomic and family factors (eg, low parental education, income, and mental health as risk factors). Causal inference analyses suggested a strong direct effect of peer relationships, but only a small direct effect of physical inactivity and a very small direct effect of screen time. CONCLUSIONS: Mental health development during adolescence can be assessed by a combination of variables from early adolescence. Peer problems represent an important direct cause of mental health development, and their deterioration may contribute to the current mental health crisis. CI - (c) Heiner Stuke, Robert Schlack, Michael Erhart, Anne Kaman, Ulrike Ravens-Sieberer, Christopher Irrgang. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org). FAU - Stuke, Heiner AU - Stuke H AUID- ORCID: 0000-0003-4011-8946 AD - Centre for Artificial Intelligence in Public Health Research of the Robert Koch-Institute, Nordufer 20, Berlin, 13353, Germany, 49 30 18754 211. AD - Department of Psychiatry and Neurosciences at the Charite Campus Mitte, Charite University Hospital Berlin, Berlin, Germany. FAU - Schlack, Robert AU - Schlack R AUID- ORCID: 0000-0002-3340-0452 AD - Department B Epidemiology and Health Monitoring, Robert Koch-Institute, Berlin, Germany. FAU - Erhart, Michael AU - Erhart M AUID- ORCID: 0009-0005-4511-2211 AD - Department of Child and Adolescent Psychiatry and Psychotherapy and Psychosomatics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. FAU - Kaman, Anne AU - Kaman A AUID- ORCID: 0000-0001-7498-6229 AD - Department of Child and Adolescent Psychiatry and Psychotherapy and Psychosomatics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. FAU - Ravens-Sieberer, Ulrike AU - Ravens-Sieberer U AUID- ORCID: 0000-0002-2031-095X AD - Department of Child and Adolescent Psychiatry and Psychotherapy and Psychosomatics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. FAU - Irrgang, Christopher AU - Irrgang C AUID- ORCID: 0000-0001-8274-1678 AD - Centre for Artificial Intelligence in Public Health Research of the Robert Koch-Institute, Nordufer 20, Berlin, 13353, Germany, 49 30 18754 211. LA - eng PT - Journal Article DEP - 20250512 PL - Canada TA - JMIR Public Health Surveill JT - JMIR public health and surveillance JID - 101669345 SB - IM MH - Humans MH - Adolescent MH - *Machine Learning MH - Male MH - Female MH - *Peer Group MH - Cohort Studies MH - Longitudinal Studies MH - Germany MH - Child MH - *Mental Disorders/epidemiology/psychology/etiology MH - *Mental Health/statistics & numerical data MH - United Kingdom PMC - PMC12088615 OTO - NOTNLM OT - Pearson correlation OT - Western countries OT - adolescence OT - adolescent OT - adolescent health OT - analogous analyses OT - assessments OT - cohort study OT - depression OT - epidemiology OT - health crisis OT - longitudinal study OT - machine learning OT - mental health OT - peer OT - physical inactivity OT - prediction OT - public health OT - risk factors OT - screen time OT - social isolation COIS- Conflicts of Interest: None declared. EDAT- 2025/05/12 18:37 MHDA- 2025/05/13 13:50 PMCR- 2025/05/12 CRDT- 2025/05/12 16:53 PHST- 2024/05/02 00:00 [received] PHST- 2025/03/18 00:00 [revised] PHST- 2025/03/22 00:00 [accepted] PHST- 2025/05/13 13:50 [medline] PHST- 2025/05/12 18:37 [pubmed] PHST- 2025/05/12 16:53 [entrez] PHST- 2025/05/12 00:00 [pmc-release] AID - v11i1e60125 [pii] AID - 60125 [pii] AID - 10.2196/60125 [doi] PST - epublish SO - JMIR Public Health Surveill. 2025 May 12;11:e60125. doi: 10.2196/60125. PMID- 40353759 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250523 IS - 2757-6256 (Print) IS - 2757-6256 (Electronic) IS - 2757-6256 (Linking) VI - 60 IP - 3 DP - 2025 May 2 TI - Reliability and Validity of the Turkish Version of a Self-Reported Sizing Me Up and a Parent-Proxy Sizing Them Up: Obesity Specific Health- Related Quality of Life Measures. PG - 334-340 LID - 10.5152/TurkArchPediatr.2025.24196 [doi] AB - Objective: Investigating the validity and reliability of the Turkish versions of the obesity-specific health-related quality of life perception scales for children and parents , Sizing Me Up/Sizing Them Up (SMU/STU), was the aim of this study. Materials and Methods: Sizing me up/sizing them up were translated into Turkish following a standardized translation procedure. Test-retest reliability, internal consistency, discriminant and convergent validity, as well as confirmatory factor analysis (CFA) were all assessed. Results: Sizing me up /sizing them up had a total scale Cronbach's alpha of 0.873, 0.872. In the test-retest evaluations, significant correlation was found in the SMU (except the Teasing/ Marginalization subscale), while no correlation was found in the Physical Functioning, Teasing/ Marginalization, School and Mealtime Difficulties subscales in the STU. The Pediatric Quality of Life Generic Core Scales (PedsQL) total mean score and the SMU/STU total mean scores exhibited a significant correlation (r=0.671, P < .0001/r=0.663, P < .001). Regarding the SMU total scale score and other subscale scores, excluding the Social Avoidance subscale, and the STU total scale score and other subscale scores, excluding Mealtime and School Functioning, a significant difference was found between the OB and non-OB samples. In CFA, the com- parative fit index (CFI) and root mean square error of approximation (RMSEA) values were not compatible with the expected values. Conclusion: The results demonstrated that both scales are suitable for use in the Turkish context and showed the validity and reliability of the Turkish versions of the SMU/STU; however, some inconsistencies were found in the items related to social avoidance in the SMU scale and posi- tive social attributes, mealtime challenges, and school functioning in the STU, so it is recom- mended that these items should be interpreted separately and carefully when evaluating scale scores by researchers or clinicians. FAU - Kizilay, Deniz Ozalp AU - Kizilay DO AD - Department of Pediatric Endocrinology and Diabetes, Ege University Faculty of Medicine, Izmir, Turkiye. FAU - Tepe, Derya AU - Tepe D AD - Division of Pediatric Endocrinology, Department of Pediatrics, Yildirim Beyazit University Yenimahalle Training and Research Hospital, Ankara, Turkiye. FAU - Ersoy, Betul AU - Ersoy B AD - Division of Pediatric Endocrinology, Department of Pediatrics, Celal Bayar University Hospital, Manisa, Turkiye. FAU - Sapmaz, Sermin Yalin AU - Sapmaz SY AD - Department of Child Psychiatry, Celal Bayar University Hospital, Manisa, Turkiye. LA - eng PT - Journal Article PL - Turkey TA - Turk Arch Pediatr JT - Turkish archives of pediatrics JID - 101776822 PMC - PMC12093398 COIS- Declaration of Interests: The authors have no conflicts of interest to declare. EDAT- 2025/05/12 12:34 MHDA- 2025/05/12 12:35 PMCR- 2025/05/02 CRDT- 2025/05/12 10:06 PHST- 2025/05/12 12:35 [medline] PHST- 2025/05/12 12:34 [pubmed] PHST- 2025/05/12 10:06 [entrez] PHST- 2025/05/02 00:00 [pmc-release] AID - tap-60-3-334 [pii] AID - 10.5152/TurkArchPediatr.2025.24196 [doi] PST - ppublish SO - Turk Arch Pediatr. 2025 May 2;60(3):334-340. doi: 10.5152/TurkArchPediatr.2025.24196. PMID- 40352210 OWN - NLM STAT- MEDLINE DCOM- 20250512 LR - 20250513 IS - 2807-2618 (Electronic) IS - 2807-2618 (Linking) VI - 5 IP - 1 DP - 2025 Apr TI - Evaluating socio-demographic, behavioral, and maternal factors in the dual burden of malnutrition among school-aged children in Batam, Indonesia. PG - e2049 LID - 10.52225/narra.v5i1.2049 [doi] LID - e2049 AB - Malnutrition among school-aged children in urban-industrial settings presents a dual burden of undernutrition and overnutrition. The aim of this study was to examine factors influencing the nutritional status of elementary school children in Batam, Indonesia. A case-control study was conducted in Batam, focusing on children aged 6-12 years, with malnourished cases (undernutrition and overnutrition) and well-nourished controls, along with their mothers. Respondents were selected through stratified random sampling from public elementary schools. Inclusion criteria encompassed children enrolled in these schools, while exclusion criteria involved children with chronic health conditions. Data were collected via structured interviews utilizing validated questionnaires, anthropometric assessments (weight-for-age and height-for-age), and parent-reported socioeconomic, behavioral and family characteristics. Statistical analysis involved binary logistic regression to identify significant risk factors associated with malnutrition. A total of 188 children, including 94 malnourished cases (40 undernutrition and 54 overnutrition) and 94 well-nourished controls. The findings revealed significant differences between cases and controls in socioeconomic factors (pocket money (p = 0.027), family income (p = 0.042)), behavioral factors (sedentary activity (p = 0.019), dietary habits (p = 0.037)) and family factors (maternal BMI, p = 0.011; maternal nutritional knowledge, p = 0.004; parenting style, p = 0.035). Dominant risk factors for malnutrition (undernutrition or overnutrition) included poor dietary habits (adjusted odds ratio (aOR): 0.451; 95%CI: 0.225-0.901; p = 0.024), maternal obesity class II (aOR: 0.126; 95%CI: 0.030-0.535; p = 0.005), and low maternal nutritional knowledge (aOR: 0.294; 95%CI: 0.124-0.696; p = 0.005). Targeted family-centered interventions focusing on dietary practices and maternal education are therefore recommended to address this issue. CI - (c) 2025 The Author(s). FAU - Erda, Roza AU - Erda R AD - Doctoral Program in Public Health, Faculty of Medicine, Universitas Andalas, Padang, Indonesia. FAU - Hamidi, Dachriyanus AU - Hamidi D AD - Departement of Pharmacy, Faculty of Pharmacy, Universitas Andalas, Padang, Indonesia. FAU - Desmawati, Desmawati AU - Desmawati D AD - Department of Nutrition Sciences, Faculty of Medicine, Universitas Andalas, Padang, Indonesia. FAU - Rasyid, Rosfita AU - Rasyid R AD - Department of Public Health, Faculty of Medicine, Universitas Andalas, Padang, Indonesia. FAU - Sarfika, Rika AU - Sarfika R AD - Department of Mental Health and Community Nursing, Faculty of Nursing, Universitas Andalas, Padang, Indonesia. LA - eng PT - Journal Article DEP - 20250221 PL - Indonesia TA - Narra J JT - Narra J JID - 9918625888906676 SB - IM MH - Humans MH - Indonesia/epidemiology MH - Child MH - Female MH - Male MH - Case-Control Studies MH - Socioeconomic Factors MH - *Mothers/statistics & numerical data MH - *Malnutrition/epidemiology MH - Nutritional Status MH - Risk Factors MH - Surveys and Questionnaires MH - Feeding Behavior PMC - PMC12059860 OTO - NOTNLM OT - Dual burden OT - dietary habit OT - malnutrition OT - maternal knowledge OT - urban-industrial setting COIS- All the authors declare that there are no conflicts of interest. EDAT- 2025/05/12 12:34 MHDA- 2025/05/12 12:35 PMCR- 2025/02/21 CRDT- 2025/05/12 06:04 PHST- 2025/01/03 00:00 [received] PHST- 2025/02/19 00:00 [accepted] PHST- 2025/05/12 12:35 [medline] PHST- 2025/05/12 12:34 [pubmed] PHST- 2025/05/12 06:04 [entrez] PHST- 2025/02/21 00:00 [pmc-release] AID - NarraJ-5-e2049 [pii] AID - 10.52225/narra.v5i1.2049 [doi] PST - ppublish SO - Narra J. 2025 Apr;5(1):e2049. doi: 10.52225/narra.v5i1.2049. Epub 2025 Feb 21. PMID- 40352034 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250513 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 17 IP - 4 DP - 2025 Apr TI - Prevalence of Overweight and Obesity Among Schoolers in Selected Schools in Ranchi, Jharkhand. PG - e81937 LID - 10.7759/cureus.81937 [doi] LID - e81937 AB - Introduction Worldwide obesity among children, especially among schoolers, has drastically increased over the years. The condition is the same in India, one of the largest democracies in the world. We conducted this study to understand the current state of obesity among schoolers in India and the factors that contribute to it. Methods This cross-sectional survey was done to determine the prevalence of obesity and investigate the connection between different underlying factors and obesity among schoolers at multiple private schools in Ranchi, Jharkhand, from January 2024 to September 2024. Height, weight, and BMI were calculated by using a calibrated weighing scale and stadiometer. A sociodemographic pro forma was used to determine the underlying factors contributing to obesity and overweight, while a standard questionnaire evaluated the related factors. Descriptive statistics were employed to assess the frequency and percentage of sociodemographic characteristics and the prevalence of obesity and overweight, whereas correlation coefficients and linear regression were used to find any relationship between sociodemographic determinants and overweight and obesity. Results The research revealed that the majority of the samples were predominantly female, representing 51.6%. Hinduism comprised 89.3% of the samples. Moreover, 51.6% of the samples were from the fifth grade. A notable 92.7% of the samples were from non-tribal ethnicities. The average BMI of pupils was 18, with an SD of 11.4. We found 2.8% of the total students as overweight, 59.5% as underweight, and 37.7% as normal weight in our survey. There was a strong link between BMI and variables like eating processed foods and ethnicity (processed foods: R = 0.135, R(2) = 0.0181, F = 5.30, p = 0.022; ethnicity: R = 0.132, R(2) = 0.0175, F = 5.10, p = 0.025). Conclusions This study revealed a gradual increase in obesity, especially in regions previously characterized by significant undernutrition. This study validates the notable disparities in obesity rates between tribal and nontribal ethnic groups and has a direct link with the consumption of processed food. The study's findings highlight the necessity for additional research in this domain. CI - Copyright (c) 2025, George et al. FAU - George, Litna AU - George L AD - College of Nursing, Rajendra Institute of Medical Sciences, Ranchi, IND. FAU - Singh, Ragini AU - Singh R AD - College of Nursing, Rajendra Institute of Medical Sciences, Ranchi, IND. FAU - Kumari, Pratima AU - Kumari P AD - College of Nursing, Rajendra Institute of Medical Sciences, Ranchi, IND. FAU - Kerketta, Prempunita AU - Kerketta P AD - College of Nursing, Rajendra Institute of Medical Sciences, Ranchi, IND. FAU - Kumari, Rajmati AU - Kumari R AD - College of Nursing, Rajendra Institute of Medical Sciences, Ranchi, IND. FAU - Kumari, Novita AU - Kumari N AD - College of Nursing, Rajendra Institute of Medical Sciences, Ranchi, IND. FAU - Kumari, Pooja AU - Kumari P AD - College of Nursing, Rajendra Institute of Medical Sciences, Ranchi, IND. LA - eng PT - Journal Article DEP - 20250409 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC12062904 OTO - NOTNLM OT - jharkhand OT - obesity OT - overweight OT - prevalence OT - schoolers COIS- Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Ethics Committee, Rajendra Institute of Medical Sciences issued approval ECR/769/INST/JH/2015/RR-21. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2025/05/12 12:33 MHDA- 2025/05/12 12:34 PMCR- 2025/04/09 CRDT- 2025/05/12 06:02 PHST- 2025/04/09 00:00 [accepted] PHST- 2025/05/12 12:34 [medline] PHST- 2025/05/12 12:33 [pubmed] PHST- 2025/05/12 06:02 [entrez] PHST- 2025/04/09 00:00 [pmc-release] AID - 10.7759/cureus.81937 [doi] PST - epublish SO - Cureus. 2025 Apr 9;17(4):e81937. doi: 10.7759/cureus.81937. eCollection 2025 Apr. PMID- 40350523 OWN - NLM STAT- MEDLINE DCOM- 20250512 LR - 20250716 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 May 11 TI - The effect of low-FODMAP diet on patients with irritable bowel syndrome. PG - 16382 LID - 10.1038/s41598-025-01163-3 [doi] LID - 16382 AB - Irritable bowel syndrome (IBS) is a chronic gastrointestinal disease that causes abdominal pain associated with alteration of bowel habits. This study aimed to assess the efficacy of low Fermentable Oligosaccharides, Disaccharides, Monosaccharides, Polyols (FODMAP) diet intervention in adult patients with mild and severe symptoms of Irritable Bowel Syndrome (IBS) in Jeddah, Saudi Arabia. The study involved a low-FODMAP dietary intervention program that included anthropometric measurements (height and weight). A total of 45 randomly selected adult IBS patients were recruited from the family medicine department at King Abdulaziz Hospital and primary healthcare centers at King Fahd Hospital in Jeddah, Saudi Arabia. The severity of IBS symptoms was assessed using the validated IBS-SSS questionnaire developed by the Rome Foundation. Additionally, dietary data were gathered through a validated semi-quantitative food frequency questionnaire (FFQ) Study participants included 68.9% females and 31.1% males, with the age group 18-30 years (66.7% of the total sample), followed by 31-45 years (33.3%). 62.2% were married and 37.8% were single. The mean BMI of the participants was 23.18 +/- 2.348 kg/m(2), 77.8% were classified as normal weight, 17.8%, overweight, and 4.4% underweight. IBS symptoms before the FODMAP intervention program were; 82.2% moderate symptoms and 17.8% severe symptoms. After the program, 86% had moderate symptoms and 14% had mild symptoms. The low-FODMAP dietary intervention led to significant improvement in IBS symptoms and encouraged healthier eating habits among adult participants. However, due to the restrictive nature of the diet, it may have contributed to changes in weight and potential nutrient deficiencies. These findings emphasize the importance of implementing such interventions under professional guidance. CI - (c) 2025. The Author(s). FAU - Alrasheedi, Amani A AU - Alrasheedi AA AD - Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah, Saudi Arabia. aalrasheedi@kau.edu.sa. FAU - Jahlan, Esra A AU - Jahlan EA AD - Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Bakarman, Marwan A AU - Bakarman MA AD - Department of Family and Community Medicine, Faculty of Medicine, King Abdulaziz University, Rabigh, Saudi Arabia. LA - eng PT - Journal Article DEP - 20250511 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Monosaccharides) RN - 0 (Disaccharides) RN - 0 (Oligosaccharides) RN - 0 (polyol) RN - 0 (Polymers) SB - IM MH - Humans MH - *Irritable Bowel Syndrome/diet therapy MH - Female MH - Male MH - Adult MH - Middle Aged MH - Young Adult MH - Monosaccharides MH - Adolescent MH - Disaccharides MH - Oligosaccharides MH - Saudi Arabia MH - Surveys and Questionnaires MH - *Diet, Carbohydrate-Restricted MH - Polymers MH - FODMAP Diet PMC - PMC12066726 OTO - NOTNLM OT - Fermentable carbohydrates OT - Irritable bowel syndrome OT - Low-FODMAP diet COIS- Declarations. Competing interests: The authors declare no competing interests. Study limitations: The main limitation of this study is the recruitment process for patients with IBS from hospitals posed difficulties, which may have affected the generalizability of our findings to a broader population of IBS patients. Additionally, the lengthy nature of the questionnaire may have discouraged some patients from participating. Another limitation is the use of a Food Frequency Questionnaire (FFQ), which relies on self-reported dietary intake. This method is prone to recall bias and inaccuracies in estimating actual consumption patterns. Moreover, FFQs may not fully capture daily variations in food intake, potentially affecting the precision of nutrient assessments. Despite these limitations, the FFQ remains a widely used and validated tool for assessing dietary patterns in nutritional research. EDAT- 2025/05/12 05:13 MHDA- 2025/05/12 06:33 PMCR- 2025/05/11 CRDT- 2025/05/11 23:18 PHST- 2024/11/23 00:00 [received] PHST- 2025/05/05 00:00 [accepted] PHST- 2025/05/12 06:33 [medline] PHST- 2025/05/12 05:13 [pubmed] PHST- 2025/05/11 23:18 [entrez] PHST- 2025/05/11 00:00 [pmc-release] AID - 10.1038/s41598-025-01163-3 [pii] AID - 1163 [pii] AID - 10.1038/s41598-025-01163-3 [doi] PST - epublish SO - Sci Rep. 2025 May 11;15(1):16382. doi: 10.1038/s41598-025-01163-3. PMID- 40349058 OWN - NLM STAT- MEDLINE DCOM- 20250511 LR - 20250514 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 24 IP - 1 DP - 2025 May 10 TI - The association between total, animal, and plant protein intake and metabolic dysfunction-associated fatty liver disease in overweight and obese children and adolescents. PG - 75 LID - 10.1186/s12937-025-01142-4 [doi] LID - 75 AB - BACKGROUND: Dietary protein plays a crucial role in the growth and development of children and adolescents. However, recent evidence has shown inconsistent findings regarding the impact of dietary protein sources on health outcomes. This study aimed to investigate the association between total, animal, and plant protein intake and the odds of metabolic dysfunction-associated fatty liver disease (MAFLD) in overweight and obese children and adolescents. METHODS: This cross-sectional study included 505 participants (52.9% males) aged 6-18 years, with a body mass index (BMI)-for-age z-score >/= 1 based on WHO standards. MAFLD diagnosis followed established consensus definitions. Dietary intake of total, animal, and plant protein was assessed using a validated 147-item food frequency questionnaire. Adjusted logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for MAFLD across protein intake and subtype quartiles. RESULTS: The participants had a mean age of 10.0 +/- 2.3 years and a mean BMI-for-age z-score of 2.70 +/- 1.01. Higher animal protein intake was significantly associated with an increased likelihood of MAFLD (highest vs. lowest quartile OR: 2.31; 95% CI: 1.01-5.30). Conversely, higher plant protein intake was significantly associated with reduced odds of MAFLD (highest vs. lowest quartile OR:0.48;95% CI:0.23-0.96). No significant relationship was found between total protein intake and MAFLD odds. CONCLUSIONS: Our findings highlight the significance of dietary protein source in the odds of MAFLD among overweight and obese children and adolescents. Further studies are warranted to confirm these findings and explore the underlying mechanisms. CI - (c) 2025. The Author(s). FAU - Nikparast, Ali AU - Nikparast A AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Sohouli, Mohammad Hassan AU - Sohouli MH AD - Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. FAU - Forouzan, Kimia AU - Forouzan K AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Farani, Mahdi Amani AU - Farani MA AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Dehghan, Pooneh AU - Dehghan P AD - Department of Imaging, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Rohani, Pejman AU - Rohani P AD - Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. rohanipejmanmd@gmail.com. FAU - Asghari, Golaleh AU - Asghari G AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. g_asghari@hotmail.com. LA - eng PT - Journal Article DEP - 20250510 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 RN - 0 (Dietary Proteins) RN - 0 (Animal Proteins, Dietary) RN - 0 (Plant Proteins) SB - IM MH - Humans MH - Male MH - Child MH - Female MH - Adolescent MH - Cross-Sectional Studies MH - *Pediatric Obesity/complications MH - *Dietary Proteins/administration & dosage MH - *Overweight/complications MH - Body Mass Index MH - *Animal Proteins, Dietary/administration & dosage MH - *Diet/methods MH - *Plant Proteins/administration & dosage MH - *Fatty Liver/etiology/epidemiology MH - *Non-alcoholic Fatty Liver Disease/epidemiology/etiology PMC - PMC12066057 OTO - NOTNLM OT - Adolescent OT - Children OT - Dietary protein OT - MAFLD OT - Metabolic dysfunction associated fatty liver disease OT - Obesity COIS- Declarations. Ethics approval and consent to participate: National nutrition and Food Technology Research Institute (NNFTRI) ethics committee approved the study protocol (IR.SBMU.NNFTRI.REC.1402.015). All participants provided written informed consent and were informed about the study. All procedures performed in studies involving human participants adhered to the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/05/11 18:58 MHDA- 2025/05/11 18:59 PMCR- 2025/05/10 CRDT- 2025/05/10 23:29 PHST- 2025/02/24 00:00 [received] PHST- 2025/04/28 00:00 [accepted] PHST- 2025/05/11 18:59 [medline] PHST- 2025/05/11 18:58 [pubmed] PHST- 2025/05/10 23:29 [entrez] PHST- 2025/05/10 00:00 [pmc-release] AID - 10.1186/s12937-025-01142-4 [pii] AID - 1142 [pii] AID - 10.1186/s12937-025-01142-4 [doi] PST - epublish SO - Nutr J. 2025 May 10;24(1):75. doi: 10.1186/s12937-025-01142-4. PMID- 40347602 OWN - NLM STAT- MEDLINE DCOM- 20250524 LR - 20260913 IS - 1872-8243 (Electronic) IS - 1386-5056 (Linking) VI - 201 DP - 2025 Sep TI - Nutritional and lifestyle predictors of rectal bleeding in functional constipation: A machine learning approach. PG - 105963 LID - S1386-5056(25)00180-7 [pii] LID - 10.1016/j.ijmedinf.2025.105963 [doi] AB - BACKGROUND: Rectal bleeding among young adults is an increasingly common clinical concern often linked with chronic constipation and unhealthy lifestyle habits. Early identification of at-risk individuals through machine learning models-based approach may help in prevention and targeted intervention. OBJECTIVES: We aim to identify dietary and lifestyle risk factors for rectal bleeding and to develop machine learning-based models for risk prediction. METHODS: A descriptive observational study was conducted on 875 Indian college going participants. A structured questionnaire assessed fiber intake, physical activity, constipation symptoms, and body mass index (BMI). Multiple machine learning algorithms were evaluated, and their performance was assessed using accuracy and area under the receiver operating characteristic curve (ROC-AUC). RESULTS: Low intake of boiled vegetables or oatmeal (<50 g/day) was associated with a 43.92 % bleeding rate (p < 0.001). Participants consuming inadequate whole grains (>25 g/day) showed a 44.81 % bleeding rate. Overweight or obese individuals exhibited a significantly higher bleeding incidence (12.26 %) than those with normal BMI (5.55 %; p = 0.008). The KNeighbors Classifier showed the highest accuracy (98.86 %) and ROC-AUC (0.994). Variables related to symptoms had greater predictive importance than those related to lifestyle. CONCLUSIONS: The findings support the role of dietary fiber and BMI in the development of rectal bleeding in constipated individuals. The predictive models demonstrate strong potential for identifying at-risk individuals and is considered a simple and useful tool for predicting rectal bleeding in functional constipation, suggesting preventive health strategies and dietary modifications. This novel algorithm might enable clinicians to perform personalized dietary strategies with improved clinical outcomes. Further validation across larger and more diverse populations is recommended. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Ghosh, Joyeta AU - Ghosh J AD - Department of Dietetics and Applied Nutrition, Amity Institute of Applied Sciences (AIAS), Amity University - Kolkata Campus, Major Arterial Road, Action Area II, Kadampukur Village, Rajarhat, Newtown, Kolkata, West Bengal 700135, India. FAU - Taneja, Jyoti AU - Taneja J AD - Department of Zoology, Daulat Ram College, University of Delhi, Delhi 110007, India. FAU - Kant, Ravi AU - Kant R AD - Molecular Microbiology, School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD England, United Kingdom. Electronic address: R.Kant@soton.ac.uk. LA - eng PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20250508 PL - Ireland TA - Int J Med Inform JT - International journal of medical informatics JID - 9711057 RN - 0 (Dietary Fiber) SB - IM MH - Humans MH - *Machine Learning MH - *Constipation/complications MH - Male MH - Female MH - *Life Style MH - Young Adult MH - *Gastrointestinal Hemorrhage/etiology/epidemiology MH - Risk Factors MH - Adult MH - Dietary Fiber MH - Body Mass Index MH - Surveys and Questionnaires MH - Adolescent MH - ROC Curve OTO - NOTNLM OT - Body mass index OT - Dietary fiber OT - Functional constipation OT - Machine learning OT - Rectal bleeding OT - Risk prediction OT - Young adults COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/05/11 18:57 MHDA- 2025/05/25 20:35 CRDT- 2025/05/10 18:04 PHST- 2025/03/04 00:00 [received] PHST- 2025/05/05 00:00 [revised] PHST- 2025/05/06 00:00 [accepted] PHST- 2025/05/25 20:35 [medline] PHST- 2025/05/11 18:57 [pubmed] PHST- 2025/05/10 18:04 [entrez] AID - S1386-5056(25)00180-7 [pii] AID - 10.1016/j.ijmedinf.2025.105963 [doi] PST - ppublish SO - Int J Med Inform. 2025 Sep;201:105963. doi: 10.1016/j.ijmedinf.2025.105963. Epub 2025 May 8. PMID- 40347237 OWN - NLM STAT- MEDLINE DCOM- 20250710 LR - 20260307 IS - 1432-0428 (Electronic) IS - 0012-186X (Print) IS - 0012-186X (Linking) VI - 68 IP - 8 DP - 2025 Aug TI - Type 1 diabetes prediction in autoantibody-positive individuals: performance, time and money matter. PG - 1709-1720 LID - 10.1007/s00125-025-06434-2 [doi] AB - AIMS/HYPOTHESIS: Efficient prediction of clinical type 1 diabetes is important for risk stratification and monitoring of autoantibody-positive individuals. In this study, we compared type 1 diabetes predictive models for predictive performance, cost and participant time needed for testing. METHODS: We developed 1943 predictive models using a Cox model based on a type 1 diabetes genetic risk score (GRS2), autoantibody count and types, BMI, age, self-reported gender and OGTT-derived glucose and C-peptide measures. We trained and validated the models using halves of a dataset comprising autoantibody-positive first-degree relatives of individuals with type 1 diabetes (n=3967, 49% female, 14.9 +/- 12.1 years of age) from the TrialNet Pathway to Prevention study. The median duration of follow-up was 4.7 years (IQR 2.0-8.1), and 1311 participants developed clinical type 1 diabetes. Models were compared for predictive performances, estimated cost and participant time. RESULTS: Models that included metabolic measures had best performance, with most exhibiting small performance differences (less than 3% and p>0.05). However, the cost and participant time associated with measuring metabolic variables ranged between US$56 and US$293 and 10-165 min, respectively. The predictive model performance had temporal variability, with the highest GRS2 influence and discriminative power being exhibited in the earliest preclinical stages. OGTT-derived metabolic measures had a similar performance to HbA(1c)- or Index(60)-derived models, with an important difference in cost and participant time. CONCLUSIONS/INTERPRETATION: Cost-performance model analyses identified trade-offs between cost and performance models, and identified cost-minimising options to tailor risk-screening strategies. CI - (c) 2025. The Author(s). FAU - Ferrat, Lauric A AU - Ferrat LA AUID- ORCID: 0000-0002-3166-9685 AD - Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK. lauric.ferrat@unige.ch. AD - Department of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland. lauric.ferrat@unige.ch. FAU - Templeman, Erin L AU - Templeman EL AUID- ORCID: 0009-0007-4306-7909 AD - Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK. FAU - Steck, Andrea K AU - Steck AK AUID- ORCID: 0000-0002-5931-9484 AD - Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. FAU - Parikh, Hemang M AU - Parikh HM AUID- ORCID: 0000-0002-9076-6709 AD - Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA. FAU - You, Lu AU - You L AUID- ORCID: 0000-0002-9400-2060 AD - Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA. FAU - Onengut-Gumuscu, Suna AU - Onengut-Gumuscu S AUID- ORCID: 0000-0002-6563-8334 AD - Department of Genome Sciences, University of Virginia, Charlottesville, VA, USA. FAU - Gottlieb, Peter A AU - Gottlieb PA AD - Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. FAU - Triolo, Taylor M AU - Triolo TM AUID- ORCID: 0000-0003-4796-6542 AD - Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. FAU - Rich, Stephen S AU - Rich SS AUID- ORCID: 0000-0003-3872-7793 AD - Department of Genome Sciences, University of Virginia, Charlottesville, VA, USA. FAU - Krischer, Jeffrey AU - Krischer J AUID- ORCID: 0000-0003-4526-888X AD - Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA. FAU - McQueen, R Brett AU - McQueen RB AUID- ORCID: 0000-0002-4302-2678 AD - Department of Clinical Pharmacy, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. FAU - Oram, Richard A AU - Oram RA AUID- ORCID: 0000-0003-3581-8980 AD - Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK. R.Oram@exeter.ac.uk. FAU - Redondo, Maria J AU - Redondo MJ AUID- ORCID: 0000-0001-5871-4645 AD - Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA. CN - Type 1 Diabetes TrialNet Study Group LA - eng GR - U01 DK106993/DK/NIDDK NIH HHS/United States GR - 3-SRA-2019-827-S-B/JDRF/United States GR - R01 DK121843-01/GF/NIH HHS/United States GR - R01 DK121843/DK/NIDDK NIH HHS/United States GR - K23 DK136931/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20250510 PL - Germany TA - Diabetologia JT - Diabetologia JID - 0006777 RN - 0 (Autoantibodies) RN - 0 (C-Peptide) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/diagnosis/immunology/economics/blood MH - Female MH - Male MH - *Autoantibodies/blood/immunology MH - Adult MH - Adolescent MH - Child MH - Young Adult MH - C-Peptide PMC - PMC12245984 OTO - NOTNLM OT - Cost analysis OT - Genetics OT - Metabolic OT - Performance assessment OT - Predictive model OT - Type 1 diabetes COIS- Acknowledgements: Parts of the content of this manuscript were communicated as an oral presentation at the ADA 81st Scientific Meeting in June 2021 and at the 6th Annual Diabetes Prevention Symposium in November 2023. Data availability: The datasets generated during and/or analysed in the current study are available from the corresponding author upon reasonable request. Interactive figures can be found online at https://lauricf.github.io/interactive_suplement.github.io/ . Code availability: The R code and the predictive model parameters that belong to the Pareto front are available at https://github.com/LauricF/ptm_performance.git . Code to generate the HLA interaction part of the GRS2 is freely available online ( https://github.com/t2diabetesgenes/t1dgrs2 ). Funding: Open access funding provided by University of Geneva. This work was funded by NIH grants R01 DK121843-01 (to MJR, AKS, LY, SO-G, PAG, SSR, JK and RAO) and grant 3-SRA-2019-827-S-B from Breakthrough T1D (formerly known as JDRF) (to LAF and RAO). TMT is supported by National Institute of Diabetes and Digestive and Kidney Diseases grant K23 DK136931. The Type 1 Diabetes TrialNet Study Group is a clinical trials network that is currently funded by the NIH through the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Allergy and Infectious Diseases, and The Eunice Kennedy Shriver National Institute of Child Health and Human Development, through the cooperative agreements U01 DK061010, U01 DK061034, U01 DK061042, U01 DK061058, U01 DK085461, U01 DK085465, U01 DK085466, U01 DK085476, U01 DK085499, U01 DK085509, U01 DK103180, U01 DK103153, U01 DK103266, U01 DK103282, U01 DK106984, U01 DK106994, U01 DK107013, U01 DK107014, UC4 DK106993, UC4DK117009, and by Breakthrough T1D (formerly known as JDRF). The contents of this article are solely the responsibility of the authors and do not necessarily represent the official views of the NIH or Breakthrough T1D. Authors' relationships and activities: RAO has received consulting fees from Janssen R & D, and previously held a UK MRC Confidence in Concept grant to develop a 10 SNP type 1 diabetes GRS biochip with Randox R & D, and received research funding from Randox R & D. MJR is a member of the Editorial Board of Diabetologia. The remaining authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work. Contribution statement: LAF, ELT, RAO and MJR contributed to the study design, as well as data analysis and interpretation, and wrote the first draft of the manuscript. AKS, RBM, JK, HMP and LY contributed to the study design and data interpretation. PAG, SO-G, TMT and SSR contributed to data interpretation. All authors revised, edited and approved the final version of the manuscript. AKS, HMP, LY, PAG, TMT, JK and MJR were members of the Type 1 Diabetes TrialNet Study Group at the time of the study. LAF, RAO and MJR are the guarantors of this article and take full responsibility for the work as a whole, including the study design, access to data and the decision to submit and publish the manuscript. EDAT- 2025/05/11 00:45 MHDA- 2025/07/10 12:30 PMCR- 2025/05/10 CRDT- 2025/05/10 11:13 PHST- 2024/10/09 00:00 [received] PHST- 2025/02/21 00:00 [accepted] PHST- 2025/07/10 12:30 [medline] PHST- 2025/05/11 00:45 [pubmed] PHST- 2025/05/10 11:13 [entrez] PHST- 2025/05/10 00:00 [pmc-release] AID - 10.1007/s00125-025-06434-2 [pii] AID - 6434 [pii] AID - 10.1007/s00125-025-06434-2 [doi] PST - ppublish SO - Diabetologia. 2025 Aug;68(8):1709-1720. doi: 10.1007/s00125-025-06434-2. Epub 2025 May 10. PMID- 40347015 OWN - NLM STAT- MEDLINE DCOM- 20250701 LR - 20250703 IS - 1440-1754 (Electronic) IS - 1034-4810 (Print) IS - 1034-4810 (Linking) VI - 61 IP - 7 DP - 2025 Jul TI - The Relationship Between Foot Posture, Validated Foot and Ankle Tests, and Hypermobility in Paediatric Population: A Cross-Sectional Study. PG - 1095-1101 LID - 10.1111/jpc.70084 [doi] AB - BACKGROUND: Previous studies have investigated flattened foot arches associated with joint hypermobility using the Beighton scale. The absence of lower limb items below the knee in the Beighton scale questions the relevance of this relationship. Addressing this query, a new validated test has been used to assess joint hypermobility, the Foot and Ankle Flexibility Index (FAFI). Utilising the FAFI, the intention was then to relate it against known reliable morphofunctional foot and ankle tests, and also a validated paediatric physical activity test. METHODS: A total of 205 healthy children, aged 5 to 10 years, participated in this cross-sectional study, which included the Lunge Test, Rest Calcaneal Stance Position (RCSP), Foot Posture Index (FPI) and 6 Minute Walking Test (6MWT). RESULTS: Significant correlations were found between FAFI and the test variables: RCSP (r = 0.334), Age (r = -0.254), FPI (r = 0.252), and 6MWT (r = -0.240). The multivariable linear regression of the hypermobility component according to FAFI presented an R (2) value of 24.9%. CONCLUSIONS: This study suggests that younger children and those with greater foot and ankle hypermobility have a more pronated foot stance, a greater range of ankle dorsiflexion, and a decreased walking speed/distance. Given the public health implications of unnecessary attention to many paediatric flatfeet presentations, these findings increase clinical clarity, using the new and validated FAFI. CI - (c) 2025 The Author(s). Journal of Paediatrics and Child Health published by John Wiley & Sons Australia, Ltd on behalf of Paediatrics and Child Health Division (The Royal Australasian College of Physicians). FAU - Martinez-Sebastian, Carlos AU - Martinez-Sebastian C AUID- ORCID: 0000-0001-9027-7860 AD - Nursing and Podiatry, Universidad de Malaga Facultad de Ciencias de la Salud, Malaga, Spain. FAU - Evans, Angela M F AU - Evans AMF AUID- ORCID: 0000-0002-5527-1161 AD - Discipline of Podiatry, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Victoria, Australia. AD - Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain. FAU - Ramos-Petersen, Laura AU - Ramos-Petersen L AUID- ORCID: 0000-0002-9349-7751 AD - Nursing and Podiatry, Universidad de Malaga Facultad de Ciencias de la Salud, Malaga, Spain. FAU - Molina-Garcia, Cristina AU - Molina-Garcia C AUID- ORCID: 0000-0003-4965-5721 AD - Department of Podiatry, Universidad Catolica San Antonio de Murcia, Campus de los Jeronimos, Murcia, Spain. FAU - Gomez-Carrion, Alvaro AU - Gomez-Carrion A AUID- ORCID: 0000-0002-7839-4789 AD - Department of Podiatry, Seville University, Seville, Spain. FAU - Gijon-Nogueron, Gabriel AU - Gijon-Nogueron G AUID- ORCID: 0000-0003-4558-3548 AD - Nursing and Podiatry, Universidad de Malaga Facultad de Ciencias de la Salud, Malaga, Spain. AD - IBIMA, University of Malaga, Malaga, Spain. LA - eng PT - Journal Article DEP - 20250510 PL - Australia TA - J Paediatr Child Health JT - Journal of paediatrics and child health JID - 9005421 SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Joint Instability/physiopathology/diagnosis MH - Child MH - Male MH - Female MH - Child, Preschool MH - *Foot/physiopathology MH - *Posture/physiology MH - *Ankle Joint/physiopathology MH - Range of Motion, Articular/physiology PMC - PMC12211541 OTO - NOTNLM OT - ankle OT - children OT - flatfeet OT - foot OT - hypermobility COIS- The authors declare no conflicts of interest. EDAT- 2025/05/11 00:45 MHDA- 2025/07/01 21:17 PMCR- 2025/07/01 CRDT- 2025/05/10 06:03 PHST- 2025/02/10 00:00 [revised] PHST- 2024/10/30 00:00 [received] PHST- 2025/04/29 00:00 [accepted] PHST- 2025/07/01 21:17 [medline] PHST- 2025/05/11 00:45 [pubmed] PHST- 2025/05/10 06:03 [entrez] PHST- 2025/07/01 00:00 [pmc-release] AID - JPC70084 [pii] AID - 10.1111/jpc.70084 [doi] PST - ppublish SO - J Paediatr Child Health. 2025 Jul;61(7):1095-1101. doi: 10.1111/jpc.70084. Epub 2025 May 10. PMID- 40346650 OWN - NLM STAT- MEDLINE DCOM- 20250510 LR - 20250512 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 13 IP - 1 DP - 2025 May 9 TI - Does depression drive technology overuse or vice-versa? a cross-lagged panel analysis of bidirectional relationships among Chinese university students. PG - 492 LID - 10.1186/s40359-025-02840-8 [doi] LID - 492 AB - BACKGROUND: The escalating prevalence of depression among university students coincides with unprecedented technology engagement, yet the directional relationship remains contested. While cross-sectional research suggests associations between technology use patterns and depressive symptoms, longitudinal evidence examining bidirectional influences remains scarce, particularly in non-Western populations. OBJECTIVE: This study aimed to examine the bidirectional relationships between specific technology use patterns and depression severity among Chinese university students using a methodologically rigorous longitudinal design. METHODS: This study conducted a four-wave longitudinal study with assessments at 3-month intervals among undergraduate students (N = 737) from three universities in eastern China. Participants completed validated measures of depression (Patient Health Questionnaire-9), anxiety (Generalized Anxiety Disorder-7), and technology use patterns (duration, timing, motivational contexts). Cross-lagged panel models with random intercepts were used to examine bidirectional relationships while controlling for between-person differences and covariates. RESULTS: Total technology use exhibited significant bidirectional relationships with depression, but specific patterns showed distinct relationships. Night-time use (beta = 0.16, 95% CI [0.08-0.24], p < 0.001) and social-comparison-motivated use (beta = 0.19, 95% CI [0.11-0.27], p < 0.001) predicted subsequent increases in depression, with stronger effects than the reverse pathway (depression to increased technology use). Conversely, depression predicted increased escapism-motivated technology use (beta = 0.23, 95% CI [0.14-0.32], p < 0.001) more strongly than the reverse pathway. Body mass index significantly moderated these relationships, with stronger technology-to-depression effects among participants with overweight/obesity (beta = 0.27, 95% CI [0.16-0.38], p < 0.001) compared to normal-weight participants (beta = 0.11, 95% CI [0.03-0.19], p = 0.009). The observed relationships remained significant after adjusting for anxiety, sleep quality, and socioeconomic factors. CONCLUSION: These findings reveal complex, pattern-specific bidirectional relationships between technology use and depression, with important temporal precedence differences. The results suggest that certain technology use contexts may contribute more strongly to depression development, while depression may drive other specific usage patterns. These findings have implications for targeted intervention approaches addressing both depression and problematic technology use among university students. CI - (c) 2025. The Author(s). FAU - Zhan, Yuting AU - Zhan Y AD - Department of Psychology, School of Education and Teach, Ningxia University, Yinchuan, Ningxia Province, 750021, China. FAU - Ding, Xu AU - Ding X AD - Shandong Academy of Medical Sciences, Shandong First Medical University, Jinan, Shandong Province, 271016, China. evelynzhanyuting@gmail.com. LA - eng PT - Journal Article DEP - 20250509 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Female MH - Male MH - *Students/psychology MH - Universities MH - China/epidemiology MH - Longitudinal Studies MH - Young Adult MH - *Depression/psychology/epidemiology MH - Adult MH - Adolescent MH - Motivation MH - Anxiety/psychology PMC - PMC12065193 OTO - NOTNLM OT - Bidirectional relationship OT - China OT - Cross-lagged panel model OT - Depression OT - Digital technology OT - Longitudinal study OT - University students COIS- Declarations. Ethics approval and consent to participate: The study has been reviewed and approval by the Shandong First Medical University Review Committee (U.R.C.), who verified that all methods used in this study were carried out in line with the 1964 Helsinki declaration and its subsequent revisions or similar ethical standards, as well as the ethical requirements of the institutional research committee. Informed consent has been obtained from all subjects involved in this study to publish this paper. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/05/10 00:48 MHDA- 2025/05/11 00:45 PMCR- 2025/05/09 CRDT- 2025/05/09 23:41 PHST- 2025/03/20 00:00 [received] PHST- 2025/05/05 00:00 [accepted] PHST- 2025/05/11 00:45 [medline] PHST- 2025/05/10 00:48 [pubmed] PHST- 2025/05/09 23:41 [entrez] PHST- 2025/05/09 00:00 [pmc-release] AID - 10.1186/s40359-025-02840-8 [pii] AID - 2840 [pii] AID - 10.1186/s40359-025-02840-8 [doi] PST - epublish SO - BMC Psychol. 2025 May 9;13(1):492. doi: 10.1186/s40359-025-02840-8. PMID- 40346463 OWN - NLM STAT- MEDLINE DCOM- 20250510 LR - 20250522 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 25 IP - 1 DP - 2025 May 9 TI - Human milk composition in women with gestational diabetes mellitus: a systematic review and meta-analysis. PG - 549 LID - 10.1186/s12884-025-07412-7 [doi] LID - 549 AB - BACKGROUND: Gestational diabetes mellitus (GDM) is a prevalent pregnancy disorder. In recent years, numerous studies have affirmed the augmented risk of obesity and diabetes mellitus in the offspring of affected individuals. Exclusive breastfeeding has been vigorously advocated as an infant feeding practice in various countries. We aimed to test our hypothesis that human milk of women with gestational diabetes differs from that of non-GDM women. METHODS: For this systematic review and meta-analysis, we searched the CNKI, PubMed, Web of Science databases, and citations for studies published between Jan 1,2000 and Sep 26, 2024. We included all studies related to human milk macronutrients. We did separate meta-analyses for carbohydrates, proteins, lipids, and energy of the colostrum and mature human milk. All analyses were performed using Revman 5.4.1 (Review Manager). The quality of the evidence was assessed with the NOS scale. Registration does not apply. FINDINGS: Of 377 records identified, 9 records were available, all of which had a moderate to high quality. Compared to non-GDM women, the colostrum of GDM women exhibited a higher protein content (MD = 0.04, 95% CI: 0.00~0.07, P = 0.03), while there were no significant disparities in carbohydrates, lipids, and energy. Simultaneously, the mature human milk of GDM women had a higher protein content (MD = 0.01, 95% CI: 0.00~0.02, P = 0.007) and a higher lipid content (MD = 0.19, 95% CI: 0.08~0.31, P = 0.001), with no significant differences in carbohydrates and energy. INTERPRETATION: There are many factors affecting the composition of human milk and fewer studies have been conducted on the composition of human milk. More high-quality studies are needed to validate the relationship between macronutrients in colostrum and carbohydrate in mature milk content with GDM. CI - (c) 2025. The Author(s). FAU - Qin, Xinyu AU - Qin X AD - Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, China. FAU - Li, Siyu AU - Li S AD - Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, China. FAU - Wang, Huiyan AU - Wang H AD - Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, China. huiyanwang@njmu.edu.cn. LA - eng GR - CJ20220117/the Application Foundation Project of Changzhou Science and Technology Bureau/ GR - CJ20220117/the Application Foundation Project of Changzhou Science and Technology Bureau/ GR - CJ20220117/the Application Foundation Project of Changzhou Science and Technology Bureau/ GR - 2022CZLJ023/the Top Talent of Changzhou "The 14th Five-Year Plan" High-Level Health Leading Talents Project/ GR - 2022CZLJ023/the Top Talent of Changzhou "The 14th Five-Year Plan" High-Level Health Leading Talents Project/ GR - 2022CZLJ023/the Top Talent of Changzhou "The 14th Five-Year Plan" High-Level Health Leading Talents Project/ PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20250509 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 RN - 0 (Lipids) SB - IM MH - Humans MH - *Diabetes, Gestational/metabolism MH - Female MH - *Milk, Human/chemistry MH - Pregnancy MH - Colostrum/chemistry MH - Lipids/analysis MH - Breast Feeding PMC - PMC12065232 OTO - NOTNLM OT - Breastfeeding OT - Gestational diabetes OT - Human milk COIS- Declarations. Ethics approval and consent to participate: Ethical approval is not required since there were no ethical issues involved in this paper. The reasons are as follows: this paper is a secondary analysis of published literatures, which are available in public databases, do not cause harm to humans, and does not involve sensitive personal information or commercial interests. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/05/10 00:48 MHDA- 2025/05/11 00:45 PMCR- 2025/05/09 CRDT- 2025/05/09 23:33 PHST- 2024/12/30 00:00 [received] PHST- 2025/03/03 00:00 [accepted] PHST- 2025/05/11 00:45 [medline] PHST- 2025/05/10 00:48 [pubmed] PHST- 2025/05/09 23:33 [entrez] PHST- 2025/05/09 00:00 [pmc-release] AID - 10.1186/s12884-025-07412-7 [pii] AID - 7412 [pii] AID - 10.1186/s12884-025-07412-7 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2025 May 9;25(1):549. doi: 10.1186/s12884-025-07412-7. PMID- 40345940 OWN - NLM STAT- MEDLINE DCOM- 20250528 LR - 20250528 IS - 1873-2623 (Electronic) IS - 0041-1345 (Linking) VI - 57 IP - 5 DP - 2025 Jun TI - Retrospective Analysis of the Effect of Sarcopenia on Mortality and Morbidity in Liver Transplant Patients. PG - 833-840 LID - S0041-1345(25)00221-0 [pii] LID - 10.1016/j.transproceed.2025.03.016 [doi] AB - BACKGROUND: Sarcopenia significantly influences morbidity and mortality in liver transplant recipients. The psoas muscle area index and prognostic nutritional index (PNI) are potential indicators of sarcopenia's impact on postoperative outcomes. However, their association with postoperative morbidity and mortality in cadaveric liver transplant recipients remains underexplored. METHODS: Data from 52 patients who underwent cadaveric liver transplantation at Cukurova University over 10 years were analyzed. Sarcopenia was assessed using psoas muscle area index (cutoffs, 4.62 mm(2)/cm(2) for males and 2.66 mm(2)/cm(2) for females, based on Bahat et al) and PNI (cutoffs, 45 for high, based on Li et al). Postoperative morbidity was evaluated using the Clavien-Dindo classification. The main outcomes were overall survival and morbidity rates. RESULTS: Sarcopenic patients had shorter survival (62.2 +/- 16.4 months) compared with nonsarcopenic patients (83.6 +/- 11.4 months), although this difference was not statistically significant (P = .370). Sarcopenia was more common in males, Child-Pugh C patients, those with ascites, American Society of Anesthesiologists score of >/=3, and a Clavien-Dindo grade of >/=3 patients. It was significantly associated with low body mass index and albumin levels (P < .05) and was more prevalent in the low PNI group. A significant correlation was observed between PNI and Child-Pugh score (P = .012), alpha fetoprotein, and albumin levels (P = .007 and P = .001). CONCLUSION: Sarcopenia negatively impacts survival, whereas a higher PNI correlates with a lower mortality risk. Further multicenter prospective studies with a larger population are needed to validate these findings. CI - Copyright (c) 2025 Elsevier Inc. All rights reserved. FAU - Demirel, Ahmet Onur AU - Demirel AO AD - Department of General Surgery, Cukurova University Faculty of Medicine, Adana, Turkey. Electronic address: odemirel@cu.edu.tr. FAU - Topal, Ugur AU - Topal U AD - Department of General Surgery Organ Transplantation, Cukurova University Faculty of Medicine, Adana, Turkey. FAU - Yavuz, Burak AU - Yavuz B AD - Department of General Surgery, Cukurova University Faculty of Medicine, Adana, Turkey. FAU - Kayci, Yunus AU - Kayci Y AD - Department of General Surgery, Cukurova University Faculty of Medicine, Adana, Turkey. FAU - Atar, Cihan AU - Atar C AD - Department of General Surgery, Cukurova University Faculty of Medicine, Adana, Turkey. FAU - Saritas, Ahmet Gokhan AU - Saritas AG AD - Department of General Surgery Organ Transplantation, Cukurova University Faculty of Medicine, Adana, Turkey. FAU - Ulku, Abdullah AU - Ulku A AD - Department of General Surgery Organ Transplantation, Cukurova University Faculty of Medicine, Adana, Turkey. FAU - Piskin, Ferhat Can AU - Piskin FC AD - Department of Radiology, Cukurova University Faculty of Medicine, Adana, Turkey. FAU - Akcam, Atilgan Tolga AU - Akcam AT AD - Department of General Surgery Organ Transplantation, Cukurova University Faculty of Medicine, Adana, Turkey. LA - eng PT - Journal Article DEP - 20250508 PL - United States TA - Transplant Proc JT - Transplantation proceedings JID - 0243532 SB - IM MH - Humans MH - *Sarcopenia/mortality/complications/diagnosis MH - *Liver Transplantation/mortality/adverse effects MH - Male MH - Female MH - Middle Aged MH - Retrospective Studies MH - Adult MH - Aged MH - Risk Factors MH - Psoas Muscles/pathology MH - Nutritional Status MH - Treatment Outcome MH - Postoperative Complications MH - Nutrition Assessment COIS- Declaration of competing interest All the authors declare no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/05/10 00:48 MHDA- 2025/05/29 00:27 CRDT- 2025/05/09 21:59 PHST- 2024/11/16 00:00 [received] PHST- 2025/03/14 00:00 [accepted] PHST- 2025/05/29 00:27 [medline] PHST- 2025/05/10 00:48 [pubmed] PHST- 2025/05/09 21:59 [entrez] AID - S0041-1345(25)00221-0 [pii] AID - 10.1016/j.transproceed.2025.03.016 [doi] PST - ppublish SO - Transplant Proc. 2025 Jun;57(5):833-840. doi: 10.1016/j.transproceed.2025.03.016. Epub 2025 May 8. PMID- 40345660 OWN - NLM STAT- MEDLINE DCOM- 20250712 LR - 20250721 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 68 DP - 2025 Aug TI - The Simple Evaluation of Food Intake (SEFI(R)) Junior as diagnostic test for malnutrition in children aged 10 to 18: prospective non-interventional multicentre transversal study. PG - 189-197 LID - S2405-4577(25)00297-9 [pii] LID - 10.1016/j.clnesp.2025.05.001 [doi] AB - INTRODUCTION AND AIMS: The Self Evaluation of Food Intake (SEFI(R)) is a visual tool to assess food intake and malnutrition risk in adults. The wording and graphics have been adapted for children and adolescents under the name SEFI(R) Junior (Jr). AIMS: to assess the SEFI(R) Jr reliability to screen for malnutrition in hospitalized children and adolescents (main); the correlation between the SEFI(R) given by the patient and the parent; iii) if the reason for hospitalization affects the SEFI(R) Jr diagnosis value (secondary). METHODS: Prospective non-interventional multicentre transversal study. INCLUSION CRITERIA: age 10-18 years, hospitalization in the Pediatrics or Child Surgery departments of four academic hospitals. The patient and one of her/his parents answered to the SEFI(R) Jr food intake visual scale blind to each other. Body mass index (BMI) < IOTF curve 18.5 and 17, Waterlow index (WI) < 90 %, height-for-age ratio <95 %, were compared to the score <7 of the SEFI(R) Jr reported by the child. STATISTICS: sensitivity (Se), specificity (Spe), positive (PPV) and negative (NPV) predictive values, area under the curve (AUC), Spearman coefficient. RESULTS: 363 patients were included: mean age+/-SD 13.5 +/- 2.1 yr, BMI 19.5 +/- 4.3, WI 105.7 +/- 26.0, 55 % boys, 61 % chronic diseases, SEFI(R) Jr 7.8 +/- 2.5, <7, n = 107 (29 %). Diagnosis of malnutrition: BMI < IOTF 18.5, n = 69 (19.0 %); BMI < IOTF 17, n = 26 (7.2 %); WI <90 %, n = 95 (26.2 %); height-for-age ratio <95 %, n = 62 (17.1 %). SEFI(R) Jr feasibility: 100 %. The SEFI(R) Jr overall performance for malnutrition diagnosis was poor: AUC 0.53 [95 % confidence interval (CI), 0.45-0.61] (vs height-for-age ratio) to 0.62 [0.55-0.68] (vs WI). SEFI(R) Jr < 7 Spe (71.2-75.8 %), Se (35.5-44.2 %), PPV (9.4-39.3 %), NPV (79.3-93.8 %) varied according to the malnutrition diagnosis criterion. The correlation between the SEFI(R) scores given by the patient and the parent was high: rho = 0.87, P < 0.0001. SEFI(R) Jr < 7 performance was the best in children hospitalized for an acute disease: vs BMI IOTF<17 (AUC = 0.74 [0.52-0.96], Spe 65.7, NPV 97.9 %), vs. height-for-age ratio <95 % (AUC = 0.69 [0.54-0.83], Spe 66.7, NPV 89.4 %), vs. IW <90 % (AUC = 0.68 [0.52-0.85], Spe 71.2, NPV 78.7 %). CONCLUSIONS: SEFI(R)Jr is feasible and may be helpful to rule out the diagnosis of malnutrition in children aged 10-18 yr and hospitalized for an acute disease. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Thibault, Ronan AU - Thibault R AD - Department of Endocrinology-Diabetology-Nutrition, CHU Rennes, Rennes, France; INRAE, INSERM, Univ Rennes, Nutrition Metabolisms Cancer, NuMeCan, Rennes, France. Electronic address: ronan.thibault@chu-rennes.fr. FAU - Bonnet, Jean-Baptiste AU - Bonnet JB AD - Department of Nutrition-Diabetes, CHU Montpellier, UMR 1302, Institute Desbrest of Epidemiology and Public Health, Univ Montpellier, INSERM, Montpellier, France. FAU - Foulon, Gauthier AU - Foulon G AD - Department of Paediatrics, CHU Rennes, Rennes, France. FAU - Arias, Adele AU - Arias A AD - INRAE, INSERM, Univ Rennes, Nutrition Metabolisms Cancer, NuMeCan, Rennes, France; Department of Paediatrics, CHU Rennes, Rennes, France. FAU - de Luca, Arnaud AU - de Luca A AD - CHRU Tours, Nutrition, Paediatrics, Inserm UMR1069 - Nutrition, Croissance et Cancer, Tours, France. FAU - Dubern, Beatrice AU - Dubern B AD - Paediatrics Nutrition and Gastroenterology, CRMR Pradort, Hopital Armand Trousseau AP-HP, INSERM, Sorbonne Universite, NutriOmique, 75012, Paris, France. FAU - Esvan, Maxime AU - Esvan M AD - CHU Rennes, Inserm, CIC, 1414, Rennes, France. FAU - Dabadie, Alain AU - Dabadie A AD - INRAE, INSERM, Univ Rennes, Nutrition Metabolisms Cancer, NuMeCan, Rennes, France; Department of Paediatrics, CHU Rennes, Rennes, France. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20250508 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - Prospective Studies MH - Adolescent MH - *Nutrition Assessment MH - Cross-Sectional Studies MH - *Malnutrition/diagnosis MH - Reproducibility of Results MH - *Eating MH - Body Mass Index MH - Nutritional Status MH - Hospitalization MH - Predictive Value of Tests OTO - NOTNLM OT - Energy intake OT - Nutritional screening OT - Paediatrics OT - Undernutrition COIS- Declaration of competing interest Ronan Thibault designed and received royalties for the Simple Evaluation of Food Intake(R) (SEFI(R)) Junior (Knoe-Groupe Get, Le Kremlin Bicetre, France). The other authors declare no conflict of interest related to this article. EDAT- 2025/05/10 00:47 MHDA- 2025/07/13 03:32 CRDT- 2025/05/09 19:40 PHST- 2025/04/30 00:00 [received] PHST- 2025/05/02 00:00 [accepted] PHST- 2025/07/13 03:32 [medline] PHST- 2025/05/10 00:47 [pubmed] PHST- 2025/05/09 19:40 [entrez] AID - S2405-4577(25)00297-9 [pii] AID - 10.1016/j.clnesp.2025.05.001 [doi] PST - ppublish SO - Clin Nutr ESPEN. 2025 Aug;68:189-197. doi: 10.1016/j.clnesp.2025.05.001. Epub 2025 May 8. PMID- 40344563 OWN - NLM STAT- MEDLINE DCOM- 20250510 LR - 20261021 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 5 DP - 2025 TI - The effect of peer relationships on college students' behavioral intentions to be physically active: The chain-mediated role of social support and exercise self-efficacy. PG - e0320845 LID - 10.1371/journal.pone.0320845 [doi] LID - e0320845 AB - PURPOSE: Physical activity behavioral intentions have a positive impact on individuals' physical and mental health, social adjustment, and academic work. This study explored the effects of peer relationships on college students' behavioral intentions for physical activity and analyzed the mediating role of social support and exercise self-efficacy. METHODS: The Peer Relationship Inventory, the Physical Activity Rating Scale-Intentions to Physical Activity Behavior subscale, the Social Support Scale, and the Exercise Self-Efficacy Scale were used to psychometrically measure 514 college students (age = 19.00 +/- 1.27) from June 3, 2024, to June 7, 2024, and the Bootstrap method was used to mediate the relationship between social support and exercise self-efficacy. RESULTS: (1) Peer relationships, social support, exercise self-efficacy and intention to engage in physical activity behaviors were positively correlated (all p < 0.01); (2) gender differences in exercise self-efficacy and intention to engage in physical activity behaviors existed (p < 0.001), and male students scored higher than female students (M +/- SD: 3.18 +/- 0.55 > 2.98 +/- 0.59; 3.23 +/- 0.62 > 2.95 +/- 0.61); (3) the mediating effect size of social support (peer relationship-->social support-->behavioral intention to exercise) was 0.078, which accounted for 8.83% of the total effect, and that of exercise self-efficacy (peer relationship-->exercise self-efficacy-->behavioral intention to exercise) was 0.314, which accounted for 35.56% of the total effect, the chained mediation effect of social support and exercise The chain mediation effect size of self-efficacy (peer relationship-->social support-->exercise self-efficacy-->behavioral intention to exercise) was 0.057, accounting for 6.46% of the total effect, and none of the confidence intervals contained 0. CONCLUSIONS: (1) College students' peer relationships can significantly and positively predict behavioral intention to exercise; (2) college students' peer relationships can have a simple influence on the behavioral intention to exercise through social support and exercise self-efficacy, respectively; (3) College student peer relationships can also influence intention to engage in physical activity through social support and exercise self-efficacy in a chained manner. CI - Copyright: (c) 2025 Zhou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Zhou, Xielin AU - Zhou X AUID- ORCID: 0009-0003-3560-9334 AD - Department of Sports Training, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Zhang, Mu AU - Zhang M AUID- ORCID: 0009-0006-4916-6273 AD - Department of Sports Training, Chengdu Sport University, Chengdu, Sichuan, China. AD - Information Technology Centre, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Chen, Lu AU - Chen L AD - Department of Sports Training, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Li, Bo AU - Li B AD - Department of Sports Training, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Xu, Jiao AU - Xu J AD - School of Physical Education, Sichuan Technology and Business University, Meishan, Sichuan, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250509 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - Male MH - *Self Efficacy MH - *Exercise/psychology MH - *Social Support MH - *Students/psychology MH - *Peer Group MH - Young Adult MH - *Intention MH - Universities MH - Surveys and Questionnaires MH - Adult MH - Adolescent PMC - PMC12064194 COIS- The authors have declared that no competing interests exist. EDAT- 2025/05/09 18:31 MHDA- 2025/05/11 00:47 PMCR- 2025/05/09 CRDT- 2025/05/09 16:13 PHST- 2024/10/09 00:00 [received] PHST- 2025/02/25 00:00 [accepted] PHST- 2025/05/11 00:47 [medline] PHST- 2025/05/09 18:31 [pubmed] PHST- 2025/05/09 16:13 [entrez] PHST- 2025/05/09 00:00 [pmc-release] AID - PONE-D-24-44384 [pii] AID - 10.1371/journal.pone.0320845 [doi] PST - epublish SO - PLoS One. 2025 May 9;20(5):e0320845. doi: 10.1371/journal.pone.0320845. eCollection 2025. PMID- 40343084 OWN - NLM STAT- MEDLINE DCOM- 20250510 LR - 20250511 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 13 DP - 2025 TI - From grit to flourishing: physical literacy's mediating role in enhancing well-being among college students with obesity. PG - e19382 LID - 10.7717/peerj.19382 [doi] LID - e19382 AB - OBJECTIVE: To investigate whether physical literacy mediates the relationship between grit and well-being among college students with obesity. METHODS: A total of 385 students with obesity were recruited. Participants completed validated questionnaires measuring grit, physical literacy, and well-being. Mediation analyses were performed to estimate indirect effects and generate bias-corrected 95% confidence intervals (CI). RESULTS: Grit was positively associated with physical literacy, and physical literacy was positively associated with well-being. Physical literacy partially mediated the relationship between grit and well-being, with the indirect effect accounting for 26.32% of the total effect (indirect effect = 0.20, 95% CI [0.09-0.31]). In a parallel mediation model analyzing the subdimensions of physical literacy, the "interaction with the environment" emerged as the strongest mediator (indirect effect = 0.15, 95% CI [0.10-0.21]), accounting for 19.74% of the total effect. The indirect effects through "motivation" and "confidence and physical competence" were also significant but accounted for smaller proportions of the total effect (6.58% and 5.26%, respectively). CONCLUSIONS: These findings serve as an initial step in understanding how physical literacy, particularly the ability to interact with the environment, partially mediates the relationship between grit and well-being among college students with obesity. Future interventional research aiming to enhance physical literacy-especially environmental engagement-is needed to confirm whether it can amplify the positive impact of grit on well-being. A multifaceted approach that fosters both psychological traits and physical competencies may prove beneficial in improving the psychological and physical health of this population. CI - (c)2025 Liu et al. FAU - Liu, Xingyu AU - Liu X AD - Badminton Technical and Tactical Analysis and Diagnostic Laboratory, National Academy of Badminton, Guangzhou Sport University, Guangzhou, China. FAU - Li, Zidong AU - Li Z AD - Badminton Technical and Tactical Analysis and Diagnostic Laboratory, National Academy of Badminton, Guangzhou Sport University, Guangzhou, China. FAU - Cheng, Wanru AU - Cheng W AD - School of Physical Education, Jinan University, Guangzhou, China. FAU - Zhang, Jian AU - Zhang J AD - School of Physical Education, Jinan University, Guangzhou, China. FAU - Ma, Xiaoyu AU - Ma X AD - School of Physical Education, Jinan University, Guangzhou, China. FAU - Tang, Di AU - Tang D AD - The Nethersole School of Nursing, Faculty of Medicine, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. FAU - Liu, Jinde AU - Liu J AD - Faculty of Physical Education, Fudan University, Shanghai, China. FAU - Gao, Tianyu AU - Gao T AD - School of Physical Education, Jinan University, Guangzhou, China. FAU - Liu, Ting AU - Liu T AD - School of Nursing, Sun Yat-sen University, Guangzhou, China. FAU - Chen, Tao AU - Chen T AD - Badminton Technical and Tactical Analysis and Diagnostic Laboratory, National Academy of Badminton, Guangzhou Sport University, Guangzhou, China. FAU - Ma, Ruisi AU - Ma R AD - School of Physical Education, Jinan University, Guangzhou, China. LA - eng PT - Journal Article DEP - 20250505 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - Female MH - Male MH - *Students/psychology MH - *Obesity/psychology MH - Universities MH - Young Adult MH - Surveys and Questionnaires MH - Adult MH - Adolescent MH - Motivation MH - *Health Literacy PMC - PMC12060899 OTO - NOTNLM OT - College students OT - Grit OT - Mediation analysis OT - Obesity OT - Physical literacy OT - Well-being COIS- The authors declare there are no competing interests. EDAT- 2025/05/09 18:34 MHDA- 2025/05/11 00:45 PMCR- 2025/05/05 CRDT- 2025/05/09 12:43 PHST- 2024/12/02 00:00 [received] PHST- 2025/04/07 00:00 [accepted] PHST- 2025/05/11 00:45 [medline] PHST- 2025/05/09 18:34 [pubmed] PHST- 2025/05/09 12:43 [entrez] PHST- 2025/05/05 00:00 [pmc-release] AID - 19382 [pii] AID - 10.7717/peerj.19382 [doi] PST - epublish SO - PeerJ. 2025 May 5;13:e19382. doi: 10.7717/peerj.19382. eCollection 2025. PMID- 40340813 OWN - NLM STAT- MEDLINE DCOM- 20250509 LR - 20250511 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 13 IP - 1 DP - 2025 May 8 TI - Exploring anxiety and sleep disorders among Edna Adan university students in Somaliland: associated stressors and insights. PG - 488 LID - 10.1186/s40359-025-02787-w [doi] LID - 488 AB - BACKGROUND: 970 million people around the world are living with mental illness. Mental illness is also one of the chronic diseases prevalent in Somaliland. Anxiety and sleep disturbances are the major types of mental illness commonly observed in young adults. The purpose of this study is to explore the anxiety, sleep disturbances, and their factor associated with Edna Adan University bachelor's students in Hargeisa, Somaliland. METHODS: This study has used a cross-sectional study with 307 bachelor students of Edna Adan University as its participants from May to July 2024. GAD-7 was used to evaluate anxiety; MPAI was used to measure mobile phone addiction; and GSDS was used to measure sleep disturbances. Pre-test for associated factors questionnaire was carried to assess the validity and reliability of questionnaire. The acquired data was then univariate and analyzed in SPSS version 26. RESULTS: Most 71.30% of the students reported having a good sleep quality, 63.50% had no problem with mobile phone addiction, and 61.20% experienced minimal to no anxiety. Academic stressors, financial pressure, and interpersonal relationships are the most frequently (9.10%) experienced linked factors with a very serious frequency (all of the time), followed by several other factors, such as teaching and learning-related stressors, mental illness and use of psychoactive substances, language barrier, body mass index (BMI) or daily meal problem, having doubt regarding the future or gambling behavior, and travel time to university. CONCLUSION: This study shows that the students mainly have minimal to no anxiety, and no addiction to mobile phone while maintaining a good sleep quality. However, sleep disturbances and anxiety-associated factors such as academic stressors, financial pressure, and interpersonal relationships are commonly experienced in a very serious frequency (all of the time). CI - (c) 2025. The Author(s). FAU - Gideon, Peiter AU - Gideon P AD - Department of Master Public Health, Edna Adan University, Hargeisa, Somaliland. peitergideon@gmail.com. FAU - Bayray, Alemayehu AU - Bayray A AD - Departement of Epidemiology, School of Public Health, Mekelle University-College of Health Sciences, Mekelle, Tigray, Ethiopia. LA - eng PT - Journal Article DEP - 20250508 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Male MH - Female MH - *Students/psychology/statistics & numerical data MH - Cross-Sectional Studies MH - Universities MH - *Anxiety/epidemiology/psychology MH - Young Adult MH - *Sleep Wake Disorders/epidemiology/psychology MH - Adult MH - *Stress, Psychological/epidemiology/psychology MH - Somalia/epidemiology MH - Surveys and Questionnaires MH - Adolescent MH - Sleep Quality MH - Cell Phone PMC - PMC12063232 OTO - NOTNLM OT - Anxiety OT - Associated stressors OT - Edna Adan University OT - Sleep disorders OT - Somaliland OT - University students COIS- Declarations. Ethical considerations: Ethical clearance was provided by Edna Adan University's Ethics Review Committee (Ref: 8055/24). Furthermore, participants granted their informed consent. All participants and their response's confidentiality have been preserved using assigned code solely for study purposes. Participants did not receive any incentive or financial compensation for taking part in the study. All methods were carried out in accordance with the principles stated in the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/05/09 12:36 MHDA- 2025/05/09 12:37 PMCR- 2025/05/08 CRDT- 2025/05/09 11:13 PHST- 2024/11/04 00:00 [received] PHST- 2025/04/23 00:00 [accepted] PHST- 2025/05/09 12:37 [medline] PHST- 2025/05/09 12:36 [pubmed] PHST- 2025/05/09 11:13 [entrez] PHST- 2025/05/08 00:00 [pmc-release] AID - 10.1186/s40359-025-02787-w [pii] AID - 2787 [pii] AID - 10.1186/s40359-025-02787-w [doi] PST - epublish SO - BMC Psychol. 2025 May 8;13(1):488. doi: 10.1186/s40359-025-02787-w. PMID- 40340577 OWN - NLM STAT- MEDLINE DCOM- 20250509 LR - 20250511 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 25 IP - 1 DP - 2025 May 8 TI - Application of machine learning in identifying risk factors for low APGAR scores. PG - 548 LID - 10.1186/s12884-025-07677-y [doi] LID - 548 AB - BACKGROUND: Identifying the risk factors for low APGAR scores at birth is critical for improving neonatal outcomes and guiding clinical interventions. METHODS: This study aimed to develop a machine-learning model that predicts low APGAR scores by incorporating maternal, fetal, and perinatal factors in Wad Medani, Sudan. Using a Random Forest Classifier, we performed hyper-parameter optimization through Grid Search cross-validation (CV) to identify the best-performing model configuration. RESULTS: The optimized model achieved excellent predictive performance, as evidenced by high F1 scores, accuracy, and balanced precision-recall metrics on the test set. In addition to prediction, feature importance analysis was conducted to identify the most influential risk factors contributing to low APGAR scores. Key predictors included gestational age, maternal BMI, mode of delivery, and history of previous complications such as stillbirth or abortion. Using 5-fold cross-validation (CV), the random forest model performance scored accuracy at 96%, precision at 98%, recall at 97%, and F1-score at 97% when classifying infants with APGAR score. CONCLUSION: This study underscores the importance of incorporating machine learning approaches in obstetric care to understand better and mitigate the risk factors associated with adverse neonatal outcomes, particularly low APGAR scores. The results provide a foundation for developing targeted interventions and improving prenatal care practices. CI - (c) 2025. The Author(s). FAU - Fahad Alhasson, Haifa AU - Fahad Alhasson H AUID- ORCID: 0000-0002-6503-2826 AD - Department of Information Technology, College of Computer, Qassim University, Buraydah 52571, Saudi Arabia. hhson@qu.edu.sa. FAU - Elhag, Nagat AU - Elhag N AUID- ORCID: 0009-0006-9159-479X AD - Wad Medani College of Medical Sciences and Technology, Wad Medani, Sudan. FAU - Saleem Alharbi, Shuaa AU - Saleem Alharbi S AUID- ORCID: 0000-0003-2121-0296 AD - Department of Information Technology, College of Computer, Qassim University, Buraydah 52571, Saudi Arabia. FAU - Adam, Ishag AU - Adam I AUID- ORCID: 0000-0001-5031-7741 AD - Department of Obstetrics and Gynecology, College of Medicine, Qassim University, Buraydah 52571, Saudi Arabia. LA - eng GR - QU-APC-2025/Deanship of Graduate Studies and Scientific Research at Qassim University/ PT - Journal Article DEP - 20250508 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - *Machine Learning MH - *Apgar Score MH - Female MH - Pregnancy MH - Risk Factors MH - Infant, Newborn MH - Adult MH - Gestational Age PMC - PMC12060381 OTO - NOTNLM OT - Artificial intelligence OT - Low APGAR score OT - Machine learning OT - Risk factors COIS- Declarations. Ethics approval and consent to participate: The study received ethical approval from the Research Board of the Faculty of Medicine, University of Gezira, Sudan (reference number 2023, #6). Written informed consent was obtained from all enrolled women in accordance with the Human Rights Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/05/09 12:36 MHDA- 2025/05/09 12:37 PMCR- 2025/05/08 CRDT- 2025/05/09 11:04 PHST- 2025/02/12 00:00 [received] PHST- 2025/05/02 00:00 [accepted] PHST- 2025/05/09 12:37 [medline] PHST- 2025/05/09 12:36 [pubmed] PHST- 2025/05/09 11:04 [entrez] PHST- 2025/05/08 00:00 [pmc-release] AID - 10.1186/s12884-025-07677-y [pii] AID - 7677 [pii] AID - 10.1186/s12884-025-07677-y [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2025 May 8;25(1):548. doi: 10.1186/s12884-025-07677-y. PMID- 40339523 OWN - NLM STAT- MEDLINE DCOM- 20250524 LR - 20250524 IS - 1879-0534 (Electronic) IS - 0010-4825 (Linking) VI - 192 IP - Pt B DP - 2025 Jun TI - Machine learning models for predicting malnutrition in NICU patients: A comprehensive benchmarking study. PG - 110326 LID - S0010-4825(25)00677-8 [pii] LID - 10.1016/j.compbiomed.2025.110326 [doi] AB - Malnutrition, affecting both adults and children globally, results from inadequate nutrient intake or loss of body mass. Traditional screening tools, reliant on detailed questionnaires, are costly, time-consuming, and often lack accuracy and generalizability. Automated machine learning (ML) alternatives promise improvements, offering efficient and versatile methods for nutritional assessment. However, they require clean, pre-processed data and careful model selection. This study aimed to evaluate the effectiveness of various ML models in predicting malnutrition. We benchmarked 22 different models for both regression and classification tasks using a malnutrition dataset. For this, a Neonatal Intensive Care Unit (NICU) patient case study was adopted. The dataset consists of 412 patients of which 232 were used to train the models. For this, a model development pipeline was developed to ensure robustness and enhance the reproducibility of the constructed models. This is achieved by testing a variety of model types including linear models, tree-based models, neural networks, and other ensemble methods. This resulted in machine learning models for both regression and classification tasks, and to optimize model efficiency by minimizing the number of required input features. The results showed that the Generalized Linear Models with Lasso or Elastic Net Regularization (GLMnet) model performed best for the regression task with an R(2) of 0.79, while the Extreme Gradient Boosting (XGBoost) model outperformed others in classification, achieving an Area Under the Curve (AUC) of 0.79. This study showcases alternatives to traditional screening methods to alleviate the burden on the healthcare system by providing reliable and automated methods for nutritional assessment that were compared on the same dataset. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Janssen, Sander M W AU - Janssen SMW AD - Information Technology Group, Wageningen University and Research, Wageningen, the Netherlands; Department of Primary and Community Care, Radboud Institute for Health Sciences, Radboudumc, Nijmegen, the Netherlands. Electronic address: sander1.janssen@wur.nl. FAU - Bouzembrak, Yamine AU - Bouzembrak Y AD - Information Technology Group, Wageningen University and Research, Wageningen, the Netherlands. FAU - Yalcin, Nadir AU - Yalcin N AD - Department of Clinical Pharmacy, Faculty of Pharmacy, Hacettepe University, Ankara, Turkiye. FAU - Tekinerdogan, Bedir AU - Tekinerdogan B AD - Information Technology Group, Wageningen University and Research, Wageningen, the Netherlands. LA - eng PT - Journal Article DEP - 20250508 PL - United States TA - Comput Biol Med JT - Computers in biology and medicine JID - 1250250 SB - IM MH - Humans MH - *Machine Learning MH - *Malnutrition/diagnosis MH - Infant, Newborn MH - *Intensive Care Units, Neonatal MH - Male MH - Female MH - Benchmarking MH - Neural Networks, Computer MH - Nutrition Assessment OTO - NOTNLM OT - Decision support OT - Machine learning OT - Malnutrition OT - Nutritional assessment OT - Nutritional screening tool OT - Precision nutrition COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/05/09 11:51 MHDA- 2025/05/25 20:35 CRDT- 2025/05/08 18:12 PHST- 2025/02/17 00:00 [received] PHST- 2025/04/14 00:00 [revised] PHST- 2025/04/30 00:00 [accepted] PHST- 2025/05/25 20:35 [medline] PHST- 2025/05/09 11:51 [pubmed] PHST- 2025/05/08 18:12 [entrez] AID - S0010-4825(25)00677-8 [pii] AID - 10.1016/j.compbiomed.2025.110326 [doi] PST - ppublish SO - Comput Biol Med. 2025 Jun;192(Pt B):110326. doi: 10.1016/j.compbiomed.2025.110326. Epub 2025 May 8. PMID- 40338562 OWN - NLM STAT- MEDLINE DCOM- 20250721 LR - 20250925 IS - 1939-134X (Electronic) IS - 1040-3590 (Linking) VI - 37 IP - 8 DP - 2025 Aug TI - Investigating the effect of experience sampling study design on careless and insufficient effort responding identified with a screen-time-based mixture model. PG - 347-359 LID - 10.1037/pas0001379 [doi] AB - When using the experience sampling method (ESM), researchers must navigate a delicate balance between obtaining fine-grained snapshots of phenomena of interest and avoiding undue respondent burden, which can lead to disengagement and compromise data quality. To guide that process, we investigated how questionnaire length and sampling frequency impact careless and insufficient effort responding (C/IER) as an important yet understudied aspect of ESM data quality. To this end, we made use of existing experimental ESM data (Eisele et al., 2022) from 163 students randomly assigned to one of two questionnaire lengths (30/60 items) and one of three sampling frequencies (3/6/9 assessments per day). We employed a novel mixture modeling approach (Ulitzsch, Nestler, et al., 2024) that leverages screen time data to disentangle attentive responding from C/IER and allows investigating how the occurrence of C/IER evolved within and across ESM study days. We found sampling frequency, but not questionnaire length, impacted C/IER, with higher frequencies resulting in higher overall C/IER proportions and sharper increases of C/IER across, but not within days. These effects proved robust across various model specifications. Further, we found no substantial relationships between model-implied C/IER and other engagement measures, such as self-reported attentiveness, attention checks, response-pattern-based attentiveness indicators, and compliance. Our findings contrast previous studies on noncompliance, suggesting that respondents may employ different strategies to lower the different types of burden imposed by questionnaire length and sampling frequency. Implications for designing ESM studies are discussed. (PsycInfo Database Record (c) 2025 APA, all rights reserved). FAU - Ulitzsch, Esther AU - Ulitzsch E AUID- ORCID: 0000-0002-9267-8542 AD - Centre for Educational Measurement, University of Oslo. FAU - Viechtbauer, Wolfgang AU - Viechtbauer W AUID- ORCID: 0000-0003-3463-4063 AD - Department of Psychiatry and Neuropsychology, Maastricht University. FAU - Ludtke, Oliver AU - Ludtke O AUID- ORCID: 0000-0001-9744-3059 AD - Leibniz Institute for Science and Mathematics Education (IPN). FAU - Myin-Germeys, Inez AU - Myin-Germeys I AUID- ORCID: 0000-0002-3731-4930 AD - Department of Neurosciences, Center for Contextual Psychiatry, KU Leuven. FAU - Nagy, Gabriel AU - Nagy G AUID- ORCID: 0000-0001-6897-212X AD - Leibniz Institute for Science and Mathematics Education (IPN). FAU - Nestler, Steffen AU - Nestler S AUID- ORCID: 0000-0001-9724-2441 AD - Department of Statistics and Psychological Methods, University of Munster. FAU - Eisele, Gudrun Vera AU - Eisele GV AUID- ORCID: 0000-0002-4466-3733 AD - Department of Neurosciences, Center for Contextual Psychiatry, KU Leuven. LA - eng GR - Research Council of Norway; Centres of Excellence/ GR - Research Foundation Flanders/ PT - Journal Article DEP - 20250508 PL - United States TA - Psychol Assess JT - Psychological assessment JID - 8915253 SB - IM MH - Humans MH - Male MH - Female MH - Young Adult MH - *Screen Time MH - *Research Design MH - Surveys and Questionnaires MH - Adult MH - Students MH - *Ecological Momentary Assessment MH - Adolescent MH - *Data Accuracy EDAT- 2025/05/08 12:24 MHDA- 2025/07/21 12:38 CRDT- 2025/05/08 11:34 PHST- 2025/07/21 12:38 [medline] PHST- 2025/05/08 12:24 [pubmed] PHST- 2025/05/08 11:34 [entrez] AID - 2026-13701-001 [pii] AID - 10.1037/pas0001379 [doi] PST - ppublish SO - Psychol Assess. 2025 Aug;37(8):347-359. doi: 10.1037/pas0001379. Epub 2025 May 8. PMID- 40336128 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250510 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 13 IP - 1 DP - 2025 May 7 TI - Empirical validation of a developmental model for binge-eating disorder in adolescents: a structural equation modeling approach. PG - 79 LID - 10.1186/s40337-025-01240-y [doi] LID - 79 AB - Loss of control (LOC) eating is characterized by a reported sense of being unable to control food intake, regardless of the amount of food consumed. It is the hallmark feature of binge-eating episodes, which involve consuming an unusually large amount of food within a discrete time frame, accompanied by a sense of LOC over eating. Some studies investigating the progression of LOC-eating symptoms in children and adolescents suggest that LOC-eating may be a precursor to binge-eating disorder (BED) in adults. To explain the progression from LOC-eating in childhood and adolescence to BED in adulthood, Tanofsky-Kraff and her colleagues developed a theoretical model highlighting three main constructs: negative affectivity, reward sensitivity, and executive functioning. However, a thorough empirical validation of this model has not yet been performed. The current study aims to empirically test Tanofsky-Kraff and her colleagues' model via structural equation modeling (SEM) and explore potential gender and age differences within this framework. We surveyed 969 adolescents aged 12 to 18 years from the Quebec City area who completed self-report questionnaires. Our findings revealed that both negative affectivity and reward sensitivity are significantly associated with binge-eating symptomatology, whereas self-reported executive functioning is not significantly associated with binge-eating symptomatology. These results support several key components of the proposed model and provide insights into the interactions between the variables when tested simultaneously. Additionally, our study underscores the importance of considering individual factors such as age and gender in understanding binge-eating symptomatology. CI - (c) 2025. The Author(s). FAU - Clermont, Camille AU - Clermont C AD - School of Psychology, Universite Laval, Quebec, Canada. FAU - Rodrigue, Christopher AU - Rodrigue C AD - Institut sur la Nutrition et les Aliments Fonctionnels de l'Universite Laval, Quebec, Canada. FAU - Begin, Catherine AU - Begin C AD - School of Psychology, Universite Laval, Quebec, Canada. catherine.begin@psy.ulaval.ca. AD - Institut sur la Nutrition et les Aliments Fonctionnels de l'Universite Laval, Quebec, Canada. catherine.begin@psy.ulaval.ca. LA - eng PT - Journal Article DEP - 20250507 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC12060550 OAB - Some young people feel they can't control how much they eat, even if they aren't eating large amounts. This is called loss of control (LOC) eating. Some research suggests that LOC eating in children and adolescents could lead to binge-eating disorder (BED) later in life. To better understand why this might happen, experts have identified three key factors: struggling with negative emotions, being more sensitive to food rewards, and having difficulties with executive functioning. However, this idea hasn't been fully tested yet. We surveyed 969 teenagers, aged 12 to 18, from the Quebec City area to explore how these three factors might be linked to binge-eating symptomatology. Our results suggest that adolescents who struggle with negative emotions or feel strongly rewarded by food might be at higher risk to report binge-eating symptoms. These findings underscore the importance of teaching young people how to manage their emotions from an early age. The also highlight the differential role of these factors depending on age and gender, which is important for developing more personalized prevention and treatment strategies. OABL- eng OTO - NOTNLM OT - Adolescents OT - Binge-eating OT - LOC-eating OT - Prevention OT - Risk factors COIS- Declarations. Ethics approval and consent to participate: The study received approval from the Laval University Research Ethics Committee. Consent was obtained directly from participants aged 14 to 18, whereas parental consent was obtained for those younger than 14 [59]. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/05/08 00:24 MHDA- 2025/05/08 00:25 PMCR- 2025/05/07 CRDT- 2025/05/07 23:44 PHST- 2024/12/21 00:00 [received] PHST- 2025/03/14 00:00 [accepted] PHST- 2025/05/08 00:25 [medline] PHST- 2025/05/08 00:24 [pubmed] PHST- 2025/05/07 23:44 [entrez] PHST- 2025/05/07 00:00 [pmc-release] AID - 10.1186/s40337-025-01240-y [pii] AID - 1240 [pii] AID - 10.1186/s40337-025-01240-y [doi] PST - epublish SO - J Eat Disord. 2025 May 7;13(1):79. doi: 10.1186/s40337-025-01240-y. PMID- 40336068 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250510 IS - 2731-913X (Electronic) IS - 2731-913X (Linking) VI - 3 IP - 1 DP - 2025 May 7 TI - Pre-sleep screen time and screen time addiction as shared determinants of poor sleep and obesity in adolescents aged 11-14 years in Scotland. PG - 42 LID - 10.1186/s44263-025-00160-y [doi] LID - 42 AB - BACKGROUND: The overall quantity of screen time has been associated with short sleep duration and increasingly sedentary lifestyles, leading to adiposity. The aim of this research was to explore which components of screen time usage are shared determinants of poor sleep and higher adiposity in adolescents, using data from the Teen Sleep Well Study. METHODS: A cross-sectional study of adolescents aged 11-14 years in Fife, Scotland was conducted. Sleep was measured objectively using the Actigraph GT3X-BT and subjectively using validated questionnaires. Adiposity was assessed using body fat percentage (BF%) and obesity was measured using body mass index percentile (BMIp). Four components of screen time were addressed using questionnaires: the timing of screen time, quantity of screen time, location of screen time, and screen time addiction. Descriptive statistics and statistical tests such as Pearson correlation tables, and adjusted regression analyses were used. Mediation analyses explored wellbeing as a factor in the association between screen time and sleep and obesity. RESULTS: Sixty-two participants (33 female/29 male, mean age 12.2 +/- 1.1 years, mean BMIp 60.3 +/- 32.1) completed the study. Excessive screen time pre-sleep (30 min before sleep) and post-sleep (first 30 min after waking), excessive screen time on a weekend, and screen time addiction were shared determinants of higher adiposity, a later chronotype (evening-preference) and poor sleep outcomes: poor sleep habits, increased insomnia symptoms (IS) and increased sleep onset variability. Mediation analyses confirmed that adolescent wellbeing mediated the association between pre-sleep screen time and IS (36.3%) and BF% (21.9%), post-sleep screen time and IS (37.7%) and BF% (30.4%), videogaming addiction and IS (31.9%) and BF% (34.6%), social media addiction and IS (35.0%) and BF% (17.4%), mobile phone addiction and IS (34.0%) and BF% (10.6%), weekday screen time and IS (58.1%) and BF% (39.8%), and weekend screen time and IS (51.4%) and BF% (38.0%). CONCLUSIONS: These screen time behaviours, alongside wellbeing should be considered in multi-component health-promoting interventions aimed at improving adolescent sleep and reducing obesity risk. Future research should employ longitudinal designs to clarify the directionality of these associations and determine the effectiveness of interventions that target both screen time behaviours and wellbeing. CI - (c) 2025. The Author(s). FAU - Gale, Emma Louise AU - Gale EL AUID- ORCID: 0000-0002-4266-6041 AD - School of Medicine, University of St. Andrews, Scotland, UK. eg243@st-andrews.ac.uk. FAU - Williams, Andrew James AU - Williams AJ AUID- ORCID: 0000-0002-2175-8836 AD - School of Health in Social Sciences, University of Edinburgh, Scotland, UK. FAU - Cecil, Joanne E AU - Cecil JE AUID- ORCID: 0000-0003-4779-6037 AD - School of Medicine, University of St. Andrews, Scotland, UK. LA - eng PT - Journal Article DEP - 20250507 PL - England TA - BMC Glob Public Health JT - BMC global and public health JID - 9918715987606676 PMC - PMC12060382 OTO - NOTNLM OT - Adiposity OT - Insomnia OT - Mobile phones OT - Overweight OT - Screens OT - Sleep disturbance OT - Teenagers COIS- Declarations. Ethics approval and consent to participate: Ethical approval for this study was granted by the University of St. Andrews School of Medicine Ethics Committee (Reference: MD16703). Written informed consent was obtained from all caregivers, and assent was obtained from all adolescent participants prior to participation. The research was conducted in accordance with the principles of the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/05/08 00:24 MHDA- 2025/05/08 00:25 PMCR- 2025/05/07 CRDT- 2025/05/07 23:41 PHST- 2024/11/04 00:00 [received] PHST- 2025/04/22 00:00 [accepted] PHST- 2025/05/08 00:25 [medline] PHST- 2025/05/08 00:24 [pubmed] PHST- 2025/05/07 23:41 [entrez] PHST- 2025/05/07 00:00 [pmc-release] AID - 10.1186/s44263-025-00160-y [pii] AID - 160 [pii] AID - 10.1186/s44263-025-00160-y [doi] PST - epublish SO - BMC Glob Public Health. 2025 May 7;3(1):42. doi: 10.1186/s44263-025-00160-y. PMID- 40335956 OWN - NLM STAT- MEDLINE DCOM- 20250508 LR - 20250515 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 May 7 TI - The prevalence and determinants of physical activity in secondary Vietnamese students: a hierarchical analysis. PG - 1694 LID - 10.1186/s12889-025-22308-z [doi] LID - 1694 AB - BACKGROUND: Physical activity (PA) levels among adolescents are low globally and in Vietnam. This study aims to assess the prevalence of PA and identify demographic, psychosocial, and behavioral factors related to PA among secondary school students in Ho Chi Minh City. METHODS: A cross-sectional study was conducted from March to May 2023, involving 475 6th-grade students. Data were collected through self-reported questionnaires and anthropometric measurements. Psychosocial factors, including self-efficacy, enjoyment, family influence, and belief in PA were measured using validated scales, while teacher influence on PA was evaluated using a custom-designed questionnaire. Sedentary behavior was assessed using the Adolescent Sedentary Activity Questionnaire (ASAQ), and PA levels were determined using the Physical Activity Questionnaire for Older Children (PAQ-C). Gender differences were analyzed using chi-square tests and t-tests. Pearson's correlation coefficient and hierarchical multiple regression were applied to examine associations and factors influencing PA. RESULTS: Only 36.8% of students met the recommended PA levels, with boys (40.7%) being more active than girls (32.9%). Boys had higher body mass index (BMI) and more screen time, while girls spent more time on cultural and social activities. Positive correlations were found between PA levels and psychosocial factors, especially in self-efficacy (r = 0.761, p < 0.001) and family influence (r = 0.717, p < 0.001). Sedentary behaviors, such as small screen recreation (r = -0.449, p < 0.001) and after-school education (r = -0.380, p < 0.001), negatively correlated with PA levels. Hierarchical analyses showed that BMI, self-efficacy, beliefs, family and teacher influence, and time spent on small screen recreation and after-school education significantly explained PA among adolescents. CONCLUSION: Vietnamese adolescents have low PA levels, with gender differences. Interventions should enhance support, reduce sedentary behavior, and address gender-specific barriers. CI - (c) 2025. The Author(s). FAU - Truong, Tram T N AU - Truong TTN AD - University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam. FAU - Huynh, Son Trung AU - Huynh ST AD - University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam. huynhtrungson@ump.edu.vn. FAU - Nguyen, Vinh Nhu AU - Nguyen VN AD - University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam. AD - University Medical Center Ho Chi Minh City, Ho Chi Minh City, Vietnam. FAU - Le Pham, An AU - Le Pham A AD - University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam. LA - eng PT - Journal Article DEP - 20250507 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Vietnam MH - Male MH - Female MH - *Exercise/psychology MH - Cross-Sectional Studies MH - Adolescent MH - *Students/statistics & numerical data/psychology MH - Surveys and Questionnaires MH - Prevalence MH - Sedentary Behavior MH - Child MH - Self Efficacy MH - Southeast Asian People PMC - PMC12060308 OTO - NOTNLM OT - ASAQ OT - Adolescent activity OT - Gender differences OT - PAQ-C OT - Psychosocial factors OT - Public health intervention OT - Sedentary behavior COIS- Declarations. Ethics approval and consent to participate: The study received ethical approval from the Ethics Committee of the University of Medicine and Pharmacy at Ho Chi Minh City (Number: 261/HDDD DHYD granted on 03/03/2023). Written consent forms were obtained from all students and their parents or guardians before participating in the study. Participants were fully informed about the study objectives, procedures, potential risks, and their right to withdraw at any time without consequences. Permissions for non-commercial use of all questionnaires in the study were granted by the corresponding author of those questionnaires under non-disclosure agreements. All procedures followed the National guidelines for ethics in biomedical research and the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/05/08 00:25 MHDA- 2025/05/08 11:14 PMCR- 2025/05/07 CRDT- 2025/05/07 23:37 PHST- 2024/09/21 00:00 [received] PHST- 2025/03/12 00:00 [accepted] PHST- 2025/05/08 11:14 [medline] PHST- 2025/05/08 00:25 [pubmed] PHST- 2025/05/07 23:37 [entrez] PHST- 2025/05/07 00:00 [pmc-release] AID - 10.1186/s12889-025-22308-z [pii] AID - 22308 [pii] AID - 10.1186/s12889-025-22308-z [doi] PST - epublish SO - BMC Public Health. 2025 May 7;25(1):1694. doi: 10.1186/s12889-025-22308-z. PMID- 40335553 OWN - NLM STAT- MEDLINE DCOM- 20250508 LR - 20250510 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 May 7 TI - The relationship between physical activity, life satisfaction, emotional regulation, and physical self esteem among college students. PG - 15899 LID - 10.1038/s41598-025-00651-w [doi] LID - 15899 AB - The satisfaction with life among college students is a multifaceted phenomenon influenced by various factors. This research investigates the influence of physical activity on the life satisfaction of college students, with a particular focus on the mediating effects of emotional regulation and physical self-esteem. Utilizing a cross-sectional approach, the study surveyed 614 freshman students at a vocational college in the Ningxia Hui Autonomous Region. The assessment tools included the Physical Activity Rating Scale (PARS-3), the Satisfaction with Life Scale, the Physical Self-Esteem Scale (PSPP), and the Adolescent Emotional Regulation Ability Scale. Data analysis was performed using SPSS 27, encompassing descriptive statistics, reliability analysis, independent sample t-tests, correlation analysis, and mediation analysis, while controlling for gender and ethnicity. The findings revealed significant gender disparities in physical activity levels, physical self-esteem, and life satisfaction among the college student population. The mediation analysis showed that although the direct effect of physical activity on life satisfaction was not statistically significant (P > 0.05), its indirect effects through emotional regulation (beta = 0.0269, P < 0.001) and physical self-esteem (beta = 0.0837, P < 0.001) were highly significant. Moreover, physical activity positively predicted life satisfaction through the combined mediating pathway of emotional regulation and physical self-esteem (beta = 0.0049, P < 0.001). Therefore, the study concludes that while the direct impact of physical activity on college students' life satisfaction might be subtle, its positive effects are primarily channeled through the mediation of emotional regulation and physical self-esteem, offering valuable insights for institutions to enhance the overall well-being of their students. CI - (c) 2025. The Author(s). FAU - Nie, Yuyang AU - Nie Y AD - College of Physical Education and Sport, Beijing Normal University, Beijing, 100875, P.R. China. AD - College of Education for the Future, Beijing Normal University, Zhuhai, 519087, P.R. China. FAU - Wang, Tianci AU - Wang T AD - College of Physical Education, Ningxia University, Yinchuan, 750021, P.R. China. FAU - Guo, Mingming AU - Guo M AD - College of Physical Education and Sport, Beijing Normal University, Beijing, 100875, P.R. China. AD - College of Education for the Future, Beijing Normal University, Zhuhai, 519087, P.R. China. FAU - Zhou, Fangbing AU - Zhou F AD - College of Physical Education and Sport, Beijing Normal University, Beijing, 100875, P.R. China. AD - College of Education for the Future, Beijing Normal University, Zhuhai, 519087, P.R. China. FAU - Ma, Wenxue AU - Ma W AD - College of Physical Education and Sport, Beijing Normal University, Beijing, 100875, P.R. China. AD - College of Education for the Future, Beijing Normal University, Zhuhai, 519087, P.R. China. FAU - Qiu, Wentao AU - Qiu W AD - College of Physical Education and Sport, Beijing Normal University, Beijing, 100875, P.R. China. AD - College of Education for the Future, Beijing Normal University, Zhuhai, 519087, P.R. China. FAU - Gao, Jinchao AU - Gao J AD - College of Education for the Future, Beijing Normal University, Zhuhai, 519087, P.R. China. gjchbnuz@163.com. FAU - Liu, Cong AU - Liu C AD - College of Physical Education and Sport, Beijing Normal University, Beijing, 100875, P.R. China. congliu@bnu.edu.cn. AD - College of Education for the Future, Beijing Normal University, Zhuhai, 519087, P.R. China. congliu@bnu.edu.cn. LA - eng GR - 29100-312200502543/congliu/ GR - 29100-312200502543/congliu/ GR - 29100-312200502543/congliu/ GR - 29100-312200502543/congliu/ GR - 29100-312200502543/congliu/ GR - 29100-312200502543/congliu/ GR - 29100-312200502543/congliu/ GR - 29100-312200502543/congliu/ PT - Journal Article DEP - 20250507 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Male MH - *Students/psychology MH - *Personal Satisfaction MH - *Self Concept MH - *Exercise/psychology MH - Young Adult MH - Universities MH - Adolescent MH - Cross-Sectional Studies MH - *Emotional Regulation MH - Surveys and Questionnaires MH - Adult PMC - PMC12059074 OTO - NOTNLM OT - Correlation OT - Emotional regulation OT - Life satisfaction OT - Physical activity OT - Physical self-esteem COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval and consent: This study was approved by the Academic Ethics Committee of the School of Physical Education and Sports at Beijing Normal University. All participants received a statement and information regarding the questionnaires they completed. EDAT- 2025/05/08 00:24 MHDA- 2025/05/08 12:24 PMCR- 2025/05/07 CRDT- 2025/05/07 23:18 PHST- 2025/01/24 00:00 [received] PHST- 2025/04/29 00:00 [accepted] PHST- 2025/05/08 12:24 [medline] PHST- 2025/05/08 00:24 [pubmed] PHST- 2025/05/07 23:18 [entrez] PHST- 2025/05/07 00:00 [pmc-release] AID - 10.1038/s41598-025-00651-w [pii] AID - 651 [pii] AID - 10.1038/s41598-025-00651-w [doi] PST - epublish SO - Sci Rep. 2025 May 7;15(1):15899. doi: 10.1038/s41598-025-00651-w. PMID- 40333998 OWN - NLM STAT- MEDLINE DCOM- 20250507 LR - 20261021 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 5 DP - 2025 TI - A study on the relationship between college students' physical exercise and feelings of inferiority: The mediating effect of social support. PG - e0321685 LID - 10.1371/journal.pone.0321685 [doi] LID - e0321685 AB - OBJECTIVE: This study explores the relationships among physical exercise, social support, and feelings of inferiority among college students, with a particular focus on the mediating role of social support. Using a sample of Chinese college students, the results demonstrate that physical exercise significantly reduces feelings of inferiority, both directly and indirectly through enhanced social support. METHOD: Pearson correlation analysis confirmed the positive correlation between physical exercise and social support, while also showing that both physical exercise and social support negatively correlate with feelings of inferiority. Structural equation modeling further supported the hypothesized relationships, revealing that the mediation pathway through social support accounted for 51.95% of the total effect. Additionally, multi-group invariance testing indicated that these relationships were consistent across genders, underscoring the universal applicability of the model. RESULTS: The findings highlight the dual pathways through which physical exercise alleviates feelings of inferiority: by fostering personal competence and enhancing social resources. CONCLUSION: This study emphasizes the importance of integrating physical exercise and social support, providing evidence-based intervention recommendations for improving students' mental health. By validating the dual-pathway model, the research offers theoretical support and practical significance for promoting students' mental health through physical exercise and social support. CI - Copyright: (c) 2025 Lei et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Lei, Huan AU - Lei H AD - School of physical education, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Peng, Bo AU - Peng B AD - School of sports training, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Tang, Minghuan AU - Tang M AD - School of History and Culture, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Chen, Weisong AU - Chen W AD - School of sports training, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Wang, Hongshen AU - Wang H AUID- ORCID: 0009-0007-8947-0234 AD - School of sports training, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Yu, Ting AU - Yu T AD - Jingshan Primary School, Changshou, Chongqing, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250507 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Social Support MH - Female MH - Male MH - *Students/psychology MH - *Exercise/psychology MH - Young Adult MH - Universities MH - Adult MH - Mental Health MH - *Emotions MH - Adolescent MH - China MH - Surveys and Questionnaires PMC - PMC12057858 COIS- The authors have declared that no competing interests exist. EDAT- 2025/05/07 18:47 MHDA- 2025/05/07 18:48 PMCR- 2025/05/07 CRDT- 2025/05/07 14:04 PHST- 2024/12/09 00:00 [received] PHST- 2025/03/10 00:00 [accepted] PHST- 2025/05/07 18:48 [medline] PHST- 2025/05/07 18:47 [pubmed] PHST- 2025/05/07 14:04 [entrez] PHST- 2025/05/07 00:00 [pmc-release] AID - PONE-D-24-56284 [pii] AID - 10.1371/journal.pone.0321685 [doi] PST - epublish SO - PLoS One. 2025 May 7;20(5):e0321685. doi: 10.1371/journal.pone.0321685. eCollection 2025. PMID- 40332291 OWN - NLM STAT- MEDLINE DCOM- 20250507 LR - 20250510 IS - 2237-9622 (Electronic) IS - 1679-4974 (Print) IS - 1679-4974 (Linking) VI - 34 DP - 2025 TI - Adaptation and validation of a tool for assessing food knowledge based on the Nova classification for the Brazilian context. PG - e20240335 LID - S2237-96222025000100221 [pii] LID - 10.1590/S2237-96222024v34e20240335.en [doi] LID - e20240335 AB - OBJECTIVES: To adapt and validate a tool to measure the level of food knowledge based on the Nova classification for the Brazilian context. METHODS: A tool developed by Canadian researchers was adapted for Brazil. In this tool, respondents assign healthiness scores to 12 images of foods with different levels of industrial processing according to the Nova classification - unprocessed and minimally processed, processed and ultra-processed. Total score is computed by comparing scores assigned to foods from different groups, and range from 0 to 8. The Brazilian version, named Nova-Conhecimento, was evaluated by experts and submitted to pre-tests with potential users. Discriminant validity was assessed by comparing scores of undergraduate students of nutrition and undergraduate students in education-related fields. Convergent validity was assessed by testing the association between the knowledge score and the consumption of ultra-processed foods in a subsample of the NutriNet Brazil cohort (n=1,245). RESULTS: Nutrition students had higher scores than education students (6.7 vs. 5.3; p-value<0.001). Each point in the knowledge score was associated with a reduction of 1.03 percentage points in the contribution of ultra-processed foods to the diet (p-value<0.001). CONCLUSION: The Nova-Conhecimento tool demonstrated validity and can contribute to food and nutritional surveillance activities based on the the Dietary Guidelines for the Brazilian Population. FAU - Gabe, Kamila Tiemann AU - Gabe KT AUID- ORCID: 0000-0001-5138-9552 AD - Universidade de Sao Paulo, Nucleo de Pesquisas Epidemiologicas em Nutricao e Saude, Sao Paulo, SP, Brazil. AD - Universidade de Sao Paulo, Faculdade de Saude Publica, Departamento de Nutricao, Sao Paulo, SP, Brazil. FAU - Bassetto Junior, Gilberto AU - Bassetto Junior G AUID- ORCID: 0009-0007-1992-2549 AD - Universidade de Sao Paulo, Nucleo de Pesquisas Epidemiologicas em Nutricao e Saude, Sao Paulo, SP, Brazil. FAU - Jaime, Patricia Constante AU - Jaime PC AUID- ORCID: 0000-0003-2291-8536 AD - Universidade de Sao Paulo, Nucleo de Pesquisas Epidemiologicas em Nutricao e Saude, Sao Paulo, SP, Brazil. AD - Universidade de Sao Paulo, Faculdade de Saude Publica, Departamento de Nutricao, Sao Paulo, SP, Brazil. LA - eng LA - por PT - Journal Article PT - Validation Study DEP - 20250502 PL - Brazil TA - Epidemiol Serv Saude JT - Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil JID - 101248287 SB - IM MH - Brazil MH - Humans MH - *Health Knowledge, Attitudes, Practice MH - Female MH - Male MH - Young Adult MH - Adult MH - Students/statistics & numerical data MH - Surveys and Questionnaires MH - *Food Handling MH - *Food/classification MH - Reproducibility of Results MH - Adolescent MH - Cohort Studies MH - *Diet PMC - PMC12052328 COIS- Conflicts of interest: None to declare. EDAT- 2025/05/07 12:31 MHDA- 2025/05/07 12:32 PMCR- 2025/05/02 CRDT- 2025/05/07 10:46 PHST- 2024/08/29 00:00 [received] PHST- 2024/11/24 00:00 [accepted] PHST- 2025/05/07 12:32 [medline] PHST- 2025/05/07 12:31 [pubmed] PHST- 2025/05/07 10:46 [entrez] PHST- 2025/05/02 00:00 [pmc-release] AID - S2237-96222025000100221 [pii] AID - 10.1590/S2237-96222024v34e20240335.en [doi] PST - epublish SO - Epidemiol Serv Saude. 2025 May 2;34:e20240335. doi: 10.1590/S2237-96222024v34e20240335.en. eCollection 2025. PMID- 40331893 OWN - NLM STAT- MEDLINE DCOM- 20260218 LR - 20260303 IS - 1527-3350 (Electronic) IS - 0270-9139 (Linking) VI - 83 IP - 3 DP - 2026 Mar 1 TI - Comparison of diagnostic accuracy and utility of non-invasive tests for clinically significant liver disease in a general population with metabolic dysfunction. PG - 591-602 LID - 10.1097/HEP.0000000000001356 [doi] AB - BACKGROUND AND AIMS: Screening for liver disease in the general population requires accurate non-invasive tests (NITs). A head-to-head comparison of NITs for early detection of clinically relevant liver disease among the target population for screening is lacking. APROACH AND RESULTS: Among the meta-cohort (Rotterdam Study and National Health and Nutrition Examination Survey) with metabolic dysfunction aged 18-80 years, 10 NITs were investigated. The diagnostic accuracy for clinically relevant conditions [increased liver stiffness measurement (LSM), at-risk metabolic dysfunction-associated steatohepatitis, advanced fibrosis, or cirrhosis) was assessed. Subgroup analysis included stratification by age group and diabetes/obesity status.We analysed 11,404 participants. Metabolic dysfunction-associated fibrosis 5 (MAF-5) obtained the highest AUC for increased LSM (>/=8 kPa: 0.80; >/=12 kPa: 0.87) and advanced fibrosis (AUC: 0.90). Fibrotic NASH index and MAF-5 performed best for detecting metabolic dysfunction-associated steatohepatitis (AUC: 0.93 and AUC: 0.92, p =ns) and SAFE for cirrhosis (AUC: 0.92). To obtain 80% sensitivity for LSM >/=8 kPa, the corresponding MAF-5 cut-off resulted in fewer referrals (42%) compared to fibrosis-4 index (77%) and higher specificity (62% vs. 24%); MAF-5 was also superior for detection of LSM >/=12 kPa and advanced fibrosis. Age-dependent scores yielded lower sensitivity among younger individuals, for example, by referring 20% of the population with the highest NIT scores, the fibrosis-4 index, steatosis-associated fibrosis estimator, NAFLD fibrosis score, FORNS, and Hepamet fibrosis score yielded <10% sensitivity for LSM >/=8 kPa among individuals aged 18-35 years, while fibrotic NASH index and MAF-5 obtained 40% and 71%. CONCLUSIONS: Of the 10 investigated NITs, MAF-5 discriminated best between all conditions except cirrhosis, for which the steatosis-associated fibrosis estimator yielded the highest accuracy. The performance of the fibrosis-4 index was poor, implying that referral pathways for significant liver disease in low-prevalence populations can be improved when more accurate NITs such as MAF-5 are employed. CI - Copyright (c) 2025 American Association for the Study of Liver Diseases. FAU - van Kleef, Laurens A AU - van Kleef LA AUID- ORCID: 0000-0002-2333-1182 AD - Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. FAU - Pustjens, Jesse AU - Pustjens J AUID- ORCID: 0009-0005-5514-4874 AD - Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. FAU - Schattenberg, Jorn M AU - Schattenberg JM AUID- ORCID: 0000-0002-4224-4703 AD - Department of Internal Medicine II, Saarland University Medical Center, Homburg, Germany. FAU - Holleboom, Adriaan G AU - Holleboom AG AUID- ORCID: 0000-0002-2911-2917 AD - Department of Vascular Internal Medicine, Amsterdam Medical Center, Amsterdam, The Netherlands. FAU - Castro Cabezas, Manuel AU - Castro Cabezas M AD - Department of Internal Medicine, Sint Franciscus Gasthuis, Rotterdam, The Netherlands. AD - Department of Internal Medicine and Endocrinology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. FAU - Tushuizen, Maarten E AU - Tushuizen ME AUID- ORCID: 0000-0001-6342-9056 AD - Department of Gastroenterology and Hepatology, Leids Universitair Medisch Centrum, Leiden, The Netherlands. FAU - de Knegt, Robert J AU - de Knegt RJ AUID- ORCID: 0000-0003-0934-6975 AD - Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. FAU - Ikram, M Arfan AU - Ikram MA AUID- ORCID: 0000-0003-0372-8585 AD - Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands. FAU - Janssen, Harry L A AU - Janssen HLA AUID- ORCID: 0000-0003-2398-8392 AD - Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. AD - Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada. FAU - Francque, Sven M AU - Francque SM AUID- ORCID: 0000-0002-7527-4714 AD - InflaMed Centre of Excellence, Laboratory for Experimental Medicine and Paediatrics, Translational Sciences in Inflammation and Immunology, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. AD - Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium. FAU - Brouwer, Willem Pieter AU - Brouwer WP AUID- ORCID: 0000-0001-8713-1481 AD - Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. LA - eng PT - Comparative Study PT - Journal Article DEP - 20250507 PL - United States TA - Hepatology JT - Hepatology (Baltimore, Md.) JID - 8302946 SB - IM MH - Humans MH - Middle Aged MH - Male MH - Female MH - Aged MH - Adult MH - *Liver Cirrhosis/diagnosis MH - *Elasticity Imaging Techniques/methods MH - Adolescent MH - Young Adult MH - *Non-alcoholic Fatty Liver Disease/diagnosis MH - Aged, 80 and over MH - Sensitivity and Specificity MH - Liver/diagnostic imaging/pathology MH - *Metabolic Diseases/complications OTO - NOTNLM OT - MASLD OT - SLD OT - epidemiology OT - external validation OT - fibrosis risk prediction OT - general population OT - screening EDAT- 2025/05/07 12:31 MHDA- 2026/02/18 19:07 CRDT- 2025/05/07 09:43 PHST- 2024/12/17 00:00 [received] PHST- 2025/03/29 00:00 [accepted] PHST- 2026/02/18 19:07 [medline] PHST- 2025/05/07 12:31 [pubmed] PHST- 2025/05/07 09:43 [entrez] AID - 01515467-202603000-00020 [pii] AID - 10.1097/HEP.0000000000001356 [doi] PST - ppublish SO - Hepatology. 2026 Mar 1;83(3):591-602. doi: 10.1097/HEP.0000000000001356. Epub 2025 May 7. PMID- 40330376 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250509 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 17 IP - 4 DP - 2025 Apr TI - Impact of Sleep and Associated Factors on the Prevalence of Early Childhood Caries: An Analytical Cross-Sectional Study. PG - e81777 LID - 10.7759/cureus.81777 [doi] LID - e81777 AB - BACKGROUND: Early childhood caries (ECC) occur soon after the eruption of teeth and can progress rapidly, causing severe impact on the physical, physiological, and psychological well-being of the child. Irregularities in sleep patterns can result in decreased salivary flow rate and the immune response, which ultimately can affect the rate of progression of early childhood caries. AIM: To assess the prevalence of early childhood caries and its association with sleep practices, the habit of frequent snacking, and the usage of phones and smart devices by children before bedtime in the age group of three to five years. METHODOLOGY: An analytical cross‑sectional study was conducted among 349 preschoolers aged three to five years studying in preschools of Gandhinagar city, Gujarat, to assess the caries prevalence and associated factors such as sleep practices and oral hygiene practices of children, as well as their snacking practice. A validated, structured questionnaire was administered to parents/guardians, and then caries status was evaluated using the deft index for each participant. Data was systematically compiled and analyzed using IBM SPSS Statistics for Windows, Version 23 (Released 2015; IBM Corp., Armonk, New York, United States). The association between early childhood caries and sleep disorder, the habit of frequent snacking, the bedtime of the child, the screen time of the child before going to bed, and oral hygiene was tested by the chi-square independent test of association. RESULT: The caries were prevalent among 238 (68.2%) children in the study population. Out of 238 children, 88 (37%) were found to have severe early childhood caries. The prevalence of caries was significantly associated with late bedtime (after 11), i.e., among 110 children (76.9%) (P=0.034), decreased sleep duration (p=0.027), extracurricular activity (p=<0.001), and late dinner time (P=0.034). Multivariate regression shows bedtime (B=1.024, p=0.003) and frequent snacking (B=-1.364, p=0.011) significantly impact deft scores (R(2)=0.042, p=0.001), with frequent snacking (OR=0.412) leading to elevated frequency of caries. CONCLUSION: The present study demonstrates the intricate relationship between sleep practices, oral hygiene, and dietary habits with the prevalence of ECC. Irregular sleep patterns, frequent snacking, and excessive screen exposure before bedtime were identified as potential risk factors contributing to the increased burden of early childhood caries (ECC). CI - Copyright (c) 2025, Patel et al. FAU - Patel, Chhaya AU - Patel C AD - Department of Pedodontics and Preventive Dentistry, Karnavati School of Dentistry, Karnavati University, Gandhinagar, IND. FAU - Patel, Megha C AU - Patel MC AD - Department of Pedodontics and Preventive Dentistry, Karnavati School of Dentistry, Karnavati University, Gandhinagar, IND. FAU - Joshi, Swasti S AU - Joshi SS AD - Department of Pedodontics and Preventive Dentistry, Karnavati School of Dentistry, Karnavati University, Gandhinagar, IND. FAU - Mehta, Miral AU - Mehta M AD - Department of Pedodontics and Preventive Dentistry, Karnavati School of Dentistry, Karnavati University, Gandhinagar, IND. FAU - Makwani, Disha AU - Makwani D AD - Department of Pedodontics and Preventive Dentistry, Karnavati School of Dentistry, Karnavati University, Gandhinagar, IND. FAU - Patel, Foram AU - Patel F AD - Department of Pedodontics and Preventive Dentistry, Karnavati School of Dentistry, Karnavati University, Gandhinagar, IND. FAU - Bale, Jessica AU - Bale J AD - Department of Pedodontics and Preventive Dentistry, Karnavati School of Dentistry, Karnavati University, Gandhinagar, IND. FAU - Solanki, Charmi AU - Solanki C AD - Department of Pedodontics and Preventive Dentistry, Karnavati School of Dentistry, Karnavati University, Gandhinagar, IND. LA - eng PT - Journal Article DEP - 20250405 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC12053214 OTO - NOTNLM OT - circadian rhythms OT - early childhood caries OT - oral hygiene OT - prevalence OT - sleep-wake patterns COIS- Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Karnavati School of Dentistry Ethics Committee issued approval KSDEC/23-24/Apr/013. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2025/05/07 11:06 MHDA- 2025/05/07 11:07 PMCR- 2025/04/05 CRDT- 2025/05/07 05:20 PHST- 2025/03/15 00:00 [received] PHST- 2025/04/05 00:00 [accepted] PHST- 2025/05/07 11:07 [medline] PHST- 2025/05/07 11:06 [pubmed] PHST- 2025/05/07 05:20 [entrez] PHST- 2025/04/05 00:00 [pmc-release] AID - 10.7759/cureus.81777 [doi] PST - epublish SO - Cureus. 2025 Apr 5;17(4):e81777. doi: 10.7759/cureus.81777. eCollection 2025 Apr. PMID- 40329998 OWN - NLM STAT- Publisher LR - 20250509 IS - 1660-3796 (Print) IS - 1660-3818 (Electronic) IS - 1660-3796 (Linking) DP - 2025 Mar 20 TI - Exploring the Characteristics of Infants That Influence Their Number of Transfusions Using a Multivariable Multiclassification Model: A Retrospective Study. PG - 1-9 LID - 10.1159/000545329 [doi] AB - INTRODUCTION: Factors that influence neonatal transfusions are poorly understood because of individual variations in birth conditions and maternal complications during pregnancy. This study aimed to establish models that incorporate perinatal factors associated with the early prediction and timely management of conditions of infants that require transfusion. METHODS: Data were collected from electronic medical records. Infants were categorized into non-transfusion, one transfusion, two transfusions, three transfusions, four transfusions, and more than four transfusions groups based on transfusions performed during hospitalization. Models were constructed to predict the number of transfusions needed by the infants using variables that showed significant differences among different transfusion groups based on multivariable, random forest, and gradient boosting tree multiclassification tasks. RESULTS: Underweight status, premature birth, Apgar scores at 1 min, 5 min, and 10 min, and gestational diabetes mellitus impacted the number of transfusions required by infants. The weighted macro-average area under the curve (AUC) values of three models constructed using previously mentioned variables were as follows: multivariable multiclassification model, AUC = 0.6549/0.7282/0.7379 on training/testing/validation sets; random forest multiclassification model, AUC = 0.8037/0.7628/0.7985 on training/testing/validation sets; and gradient boosting tree multiclassification model, AUC = 0.7422/0.7038/0.7488 on training/testing/validation sets. The weighted macro-average AUC of the three models constructed using Apgar scores were as follows: multivariable multiclassification model, AUC = 0.6425/0.7044/0.7379 on training/testing/validation sets; random forest multiclassification model, AUC = 0.7659/0.7662/0.7985 on training/testing/validation sets; and gradient boosting tree multiclassification model, AUC = 0.6559/0.6251/0.7488 on training/testing/validation sets. CONCLUSION: Apgar scores at 1 min, 5 min, and 10 min may be preliminary predictive factors that could be used to implement early transfusion strategies for infants after birth. Because of the limitations of the data volume, variable selection, and model performance evaluation, further optimization and improvements are necessary to develop accurate blood transfusion prediction models for infants. CI - (c) 2025 The Author(s). Published by S. Karger AG, Basel. FAU - Zhang, Mengyi AU - Zhang M AD - Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. FAU - Chen, Jian AU - Chen J AD - Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. FAU - Feng, Jing AU - Feng J AD - Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. FAU - Luo, Jie AU - Luo J AD - Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. FAU - Guo, Binhan AU - Guo B AD - Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. LA - eng PT - Journal Article DEP - 20250320 PL - Switzerland TA - Transfus Med Hemother JT - Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie JID - 101176417 PMC - PMC12052351 OTO - NOTNLM OT - Machine learning OT - Multiclassification model OT - Neonatal transfusion OT - Perinatal factor COIS- The authors have no conflicts of interest to declare. EDAT- 2025/05/07 06:28 MHDA- 2025/05/07 06:28 PMCR- 2025/03/20 CRDT- 2025/05/07 05:14 PHST- 2024/11/29 00:00 [received] PHST- 2025/03/17 00:00 [accepted] PHST- 2025/05/07 06:28 [medline] PHST- 2025/05/07 06:28 [pubmed] PHST- 2025/05/07 05:14 [entrez] PHST- 2025/03/20 00:00 [pmc-release] AID - 545329 [pii] AID - 10.1159/000545329 [doi] PST - aheadofprint SO - Transfus Med Hemother. 2025 Mar 20:1-9. doi: 10.1159/000545329. PMID- 40329384 OWN - NLM STAT- MEDLINE DCOM- 20250507 LR - 20250509 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 13 IP - 1 DP - 2025 May 6 TI - The relationship between physical activity and social network site addiction among adolescents: the chain mediating role of anxiety and ego-depletion. PG - 477 LID - 10.1186/s40359-025-02785-y [doi] LID - 477 AB - BACKGROUND AND OBJECTIVES: Physical activity is associated with social network site addiction in adolescents, yet the mechanisms remain unclear. This study examines whether anxiety and ego-depletion mediate this relationship. METHODS: A survey was conducted among 1,174 Chinese adolescents (614 boys, 560 girls; mean age = 12.59, SD = 1.13). Physical activity was assessed with a single item on moderate-to-vigorous exercise in the past 7 days. Social network site addiction, anxiety, and ego-depletion were measured using validated self-report questionnaires. Descriptive statistics, correlation analyses, and a chained mediation model were employed. RESULTS: Physical activity was negatively correlated with social network site addiction (r = -0.165, p < 0.001), anxiety (r = -0.121, p < 0.001), and ego-depletion (r = -0.119, p < 0.001). Anxiety was positively correlated with ego-depletion (r = 0.574, p < 0.001) and social network site addiction (r = 0.388, p < 0.001). Ego-depletion was positively associated with social network site addiction (r = 0.456, p < 0.001). Anxiety and ego-depletion sequentially mediated the relationship between physical activity and social network site addiction. CONCLUSION: This study clarifies the psychological mechanisms linking physical activity and social network site addiction in adolescents, identifying anxiety and ego-depletion as key mediators. The findings emphasize the need to target these factors for more effective interventions. CI - (c) 2025. The Author(s). FAU - Wang, Jiale AU - Wang J AD - School of Sports Science, Jishou University, Jishou, China. FAU - Xiao, Ting AU - Xiao T AD - School of Sports Science, Jishou University, Jishou, China. FAU - Liu, Yang AU - Liu Y AD - School of Sports Science, Jishou University, Jishou, China. ldyedu@foxmail.com. FAU - Guo, Zhenhua AU - Guo Z AD - School of Sports Science, Jishou University, Jishou, China. FAU - Yi, Zhenxiu AU - Yi Z AD - School of Sports Training, Chengdu Sport University, Chengdu, China. LA - eng PT - Journal Article DEP - 20250506 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Male MH - Female MH - Adolescent MH - *Exercise/psychology MH - *Anxiety/psychology MH - *Ego MH - *Behavior, Addictive/psychology MH - Child MH - *Social Networking MH - Surveys and Questionnaires MH - China MH - *Internet Addiction Disorder/psychology MH - *Adolescent Behavior/psychology PMC - PMC12057064 OTO - NOTNLM OT - Adolescents OT - Anxiety OT - Ego-depletion OT - Physical activity OT - Social network site addiction COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Biomedicine Ethics Committee of Jishou University before the initiation of the project (Grant number: JSDX-2024-0086). And informed consent was obtained from the participants and their guardians before starting the program. We confirm that all the experiment is in accordance with the relevant guidelines and regulations such as the declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/05/07 00:27 MHDA- 2025/05/07 06:27 PMCR- 2025/05/06 CRDT- 2025/05/06 23:43 PHST- 2024/11/02 00:00 [received] PHST- 2025/04/22 00:00 [accepted] PHST- 2025/05/07 06:27 [medline] PHST- 2025/05/07 00:27 [pubmed] PHST- 2025/05/06 23:43 [entrez] PHST- 2025/05/06 00:00 [pmc-release] AID - 10.1186/s40359-025-02785-y [pii] AID - 2785 [pii] AID - 10.1186/s40359-025-02785-y [doi] PST - epublish SO - BMC Psychol. 2025 May 6;13(1):477. doi: 10.1186/s40359-025-02785-y. PMID- 40328408 OWN - NLM STAT- MEDLINE DCOM- 20250521 LR - 20250521 IS - 1872-8227 (Electronic) IS - 0168-8227 (Linking) VI - 224 DP - 2025 Jun TI - Development and validation of a scale measuring perceived barriers to physical activity in Spanish for children and adolescents with type 1 diabetes: the Physical Activity Barriers Scale for pediatric type 1 diabetes (PABS-1) questionnaire. PG - 112223 LID - S0168-8227(25)00237-2 [pii] LID - 10.1016/j.diabres.2025.112223 [doi] AB - AIMS: To develop and validate the psychometric properties, reliability, and criterion validity of the Physical Activity Barriers Scale for pediatric type 1 diabetes (PABS-1) in Spanish-speaking children and adolescents with type 1 diabetes. METHOD: A cross-sectional study was conducted with a sample of 93 Spanish-speaking children and adolescents with type 1 diabetes. The PABS-1 questionnaire was developed by experts and refined with patient feedback. Its validity was assessed by comparing results with accelerometer data, linking scores to objective physical activity measures. RESULTS: The PABS-1 showed good internal consistency, with a Cronbach's alpha (alpha) coefficient of 0.89, indicating strong reliability. Confirmatory factor analysis supported a four-factor structure, with physical, diabetes-related, psychological, and environmental barriers showing good fit indices (comparative fit index [CFA] = 0.94, root mean square error of [RMSEA] = 0.06, standardized root mean square residual [SRMR] = 0.05). Although the associations were small, the total PABS-1 score was significantly negatively correlated with cardiorespiratory fitness (Spearman's rho [rho]= -0.15, p = 0.035) and moderate-to-vigorous physical activity (rho = -0.12, p = 0.039). Among the four factors, motivational barriers exhibited the strongest associations with physical activity and fitness, showing significant negative correlations. CONCLUSIONS: The PABS-1 is a valid and reliable tool for assessing perceived barriers to physical activity in Spanish-speaking children and adolescents with type 1 diabetes. CI - Copyright (c) 2025 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Garcia-Hermoso, Antonio AU - Garcia-Hermoso A AD - Navarrabiomed, Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), IdiSNA, Pamplona 31010, Spain. Electronic address: antonio.garciah@unavarra.es. FAU - Huerta-Uribe, Nidia AU - Huerta-Uribe N AD - Navarrabiomed, Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), IdiSNA, Pamplona 31010, Spain. FAU - Hormazabal-Aguayo, Ignacio AU - Hormazabal-Aguayo I AD - Navarrabiomed, Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), IdiSNA, Pamplona 31010, Spain; Vicerrectoria de Investigacion y Postgrado, Universidad de La Serena, La Serena, Chile. FAU - Munoz-Pardeza, Jacinto AU - Munoz-Pardeza J AD - Navarrabiomed, Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), IdiSNA, Pamplona 31010, Spain. FAU - Chueca-Guindulain, Maria J AU - Chueca-Guindulain MJ AD - Pediatric Endocrinology Unit, Hospital Universitario de Navarra (CHN), IdiSNA, Pamplona 31010, Spain. FAU - Sanchez, Elisabet Burillo AU - Sanchez EB AD - Pediatric Endocrinology Unit, Hospital Universitario de Navarra (CHN), IdiSNA, Pamplona 31010, Spain. FAU - Ezzatvar, Yasmin AU - Ezzatvar Y AD - Lifestyle Factors with Impact on Ageing and Overall Health (LAH) Research Group. Department of Nursing. University of Valencia, Valencia, Spain. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AD - School of Medicine, Universidad Espiritu Santo, Samborondon, Ecuador; Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno, Chile. LA - eng PT - Journal Article PT - Validation Study DEP - 20250504 PL - Ireland TA - Diabetes Res Clin Pract JT - Diabetes research and clinical practice JID - 8508335 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/psychology/physiopathology MH - Adolescent MH - Child MH - Female MH - Male MH - *Exercise/psychology/physiology MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - Psychometrics MH - Reproducibility of Results MH - Spain OTO - NOTNLM OT - Barriers OT - Exercise OT - Insulin-dependent diabetes OT - Reliability, criterion validity COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/05/07 00:27 MHDA- 2025/05/22 00:28 CRDT- 2025/05/06 19:27 PHST- 2025/04/02 00:00 [received] PHST- 2025/04/24 00:00 [revised] PHST- 2025/05/01 00:00 [accepted] PHST- 2025/05/22 00:28 [medline] PHST- 2025/05/07 00:27 [pubmed] PHST- 2025/05/06 19:27 [entrez] AID - S0168-8227(25)00237-2 [pii] AID - 10.1016/j.diabres.2025.112223 [doi] PST - ppublish SO - Diabetes Res Clin Pract. 2025 Jun;224:112223. doi: 10.1016/j.diabres.2025.112223. Epub 2025 May 4. PMID- 40327756 OWN - NLM STAT- MEDLINE DCOM- 20250925 LR - 20250925 IS - 1486-3847 (Electronic) IS - 1486-3847 (Linking) VI - 86 IP - 3 DP - 2025 Sep 1 TI - Attitudes and Dietary Behaviours among Athletes Engaged in Weight-Sensitive Performance Sports: A Mixed-Methods Study. PG - 134-144 LID - 10.3148/cjdpr-2025-007 [doi] AB - Purpose: This mixed-methods study investigated disordered eating attitudes and behaviours (DEAB) and the risk of eating disorders (ED) in adult athletes engaged in weight-sensitive sports, while also exploring their dietary concerns and body image perception. Methods: Fifty athletes (mean age 25.9 years) recruited across New Brunswick completed two validated self-administered questionnaires (the Eating Disorders Screen for Athletes (EDSA) and the Eating Disorder Examination Questionnaire (EDE-Q)) focusing on dietary concerns and body image perception. Ten individuals also participated in an individual interview. Results: DEAB and concerns about body image were widespread among participants. The mean EDSA score approached the high-risk threshold for ED, while the EDE-Q score remained below the diagnostic cutoff value. Both scores were significantly higher in females than males. EDE-Q scores in aesthetic sports were twofold greater than in gravitational sports. Two main themes convey the athletes' perspectives: perception of an ideal body image in sports and perceived strong association between athletic performance level and weight or body shape, with sub-themes depicting the influence of various stakeholders and the sports environment, the experience of DEAB, and the athlete's journey. Conclusions: Identifying ED among athletes participating in weight-sensitive sports requires a broad approach not limited to ED diagnostic criteria and should encompass those displaying DEAB, thus emphasizing prevention. Sociocultural factors such as the sport culture should also be addressed. FAU - Leger, Mia MSc, RD AU - Leger M. MSc, RD AD - School of Food Science, Nutrition and Family Studies, Faculty of Health Sciences and Community Services, Universite de Moncton, Moncton, New Brunswick, Canada. FAU - Tranchant, Carole C PhD AU - Tranchant C.C. PhD AD - School of Food Science, Nutrition and Family Studies, Faculty of Health Sciences and Community Services, Universite de Moncton, Moncton, New Brunswick, Canada. FAU - Ross-Plourde, Mylene PhD AU - Ross-Plourde M. PhD AD - School of Psychology, Faculty of Health Sciences and Community Services, Universite de Moncton, Moncton, New Brunswick, Canada. FAU - Dube, Anik PhD, RN AU - Dube A. PhD, RN AD - School of Nursing, Faculty of Health Sciences and Community Services, Universite de Moncton, Moncton, New Brunswick, Canada. LA - eng PT - Journal Article DEP - 20250506 PL - Canada TA - Can J Diet Pract Res JT - Canadian journal of dietetic practice and research : a publication of Dietitians of Canada = Revue canadienne de la pratique et de la recherche en dietetique : une publication des Dietetistes du Canada JID - 9811151 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - *Athletes/psychology MH - *Body Image/psychology MH - *Feeding and Eating Disorders/psychology/epidemiology MH - Young Adult MH - Surveys and Questionnaires MH - *Feeding Behavior/psychology MH - *Sports/psychology MH - *Diet/psychology MH - Body Weight MH - Adolescent MH - *Athletic Performance/psychology OTO - NOTNLM OT - alimentation desordonnee OT - athletes OT - athletes OT - body image OT - disordered eating OT - eating disorders OT - image corporelle OT - sports sensibles au poids OT - troubles alimentaires OT - weight-sensitive sports EDAT- 2025/05/06 18:29 MHDA- 2025/09/25 18:31 CRDT- 2025/05/06 14:12 PHST- 2025/09/25 18:31 [medline] PHST- 2025/05/06 18:29 [pubmed] PHST- 2025/05/06 14:12 [entrez] AID - 10.3148/cjdpr-2025-007 [doi] PST - ppublish SO - Can J Diet Pract Res. 2025 Sep 1;86(3):134-144. doi: 10.3148/cjdpr-2025-007. Epub 2025 May 6. PMID- 40323910 OWN - NLM STAT- MEDLINE DCOM- 20250505 LR - 20261021 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 5 DP - 2025 TI - Type 1 diabetes mellitus in children: Patient reported outcomes. PG - e0322882 LID - 10.1371/journal.pone.0322882 [doi] LID - e0322882 AB - The global prevalence of type 1 diabetes mellitus (T1DM) is increasing. Poor glycemic control in children and adolescents leads to both acute and chronic problems, reduced Health Related Quality of Life (HRQoL), and higher healthcare utilization. This study aimed to assess patient-reported outcomes related to self-management adherence, QoL, diabetes-related stigma, glycemic control, and other clinical outcomes along with their determinants, in insulin-treated pediatric T1DM patients in Jordan. A cross-sectional study was conducted from April to October 2023 at two health centers in Northern Jordan. Eligible pediatric T1DM patients attending outpatient clinics were enrolled. Trained pharmacists conducted face-to-face interviews with both children and their guardians, using validated tools that were translated into Arabic. Adherence was evaluated using the Diabetes Management Questionnaire, HRQoL was measured using the Pediatric Quality of Life Inventory 3.0 Diabetes Module, stigma was assessed using the Child Attitude Toward Illness Scale and glycemic control was determined by glycated hemoglobin levels. A total of 150 patients participated in the study. The mean adherence score was 57.4 +/- 18.13. Factors such as younger age (P-value = 0.01), higher monthly income (P-value = 0.022) and shorter disease duration (P-value = 0.008) were associated with improved adherence. The mean pediatric QoL score was 63.27 +/- 11.86, with male gender (P-value = 0.021) and the absence of disease-related factors (P-value = 0.004) linked to lower QoL scores. Additionally, body mass index (P-value = 0.041) and a family history of DM (P-value = 0.047) were linked to stigma. Most patients (76%) had uncontrolled diabetes, with disease duration (P-value = 0.019) and maternal educational level (P-value = 0.013) influencing glycemic control. These findings highlight that, despite widespread poor glycemic control, insulin adherence and QoL among pediatric T1DM patients in Jordan are above average. Targeted interventions are recommended to improve adherence and, in turn, overall patient outcomes. CI - Copyright: (c) 2025 Almomani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Almomani, Basima A AU - Almomani BA AUID- ORCID: 0000-0002-2229-5837 AD - Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan. FAU - Elayyan, Roa'a N AU - Elayyan RN AD - Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan. FAU - Al-Shatnawi, Samah F AU - Al-Shatnawi SF AD - Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250505 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Glycated Hemoglobin) RN - 0 (Insulin) RN - 0 (Hypoglycemic Agents) SB - IM MH - Humans MH - Male MH - *Diabetes Mellitus, Type 1/drug therapy/epidemiology/psychology/blood MH - Female MH - Child MH - Quality of Life MH - Adolescent MH - Cross-Sectional Studies MH - Jordan/epidemiology MH - *Patient Reported Outcome Measures MH - Glycated Hemoglobin/analysis MH - Social Stigma MH - Insulin/therapeutic use MH - Glycemic Control MH - Hypoglycemic Agents/therapeutic use MH - Surveys and Questionnaires MH - Medication Adherence MH - Self-Management MH - Child, Preschool PMC - PMC12052175 COIS- The authors have declared that no competing interests exist. EDAT- 2025/05/05 18:34 MHDA- 2025/05/05 18:35 PMCR- 2025/05/05 CRDT- 2025/05/05 13:33 PHST- 2024/07/04 00:00 [received] PHST- 2025/03/28 00:00 [accepted] PHST- 2025/05/05 18:35 [medline] PHST- 2025/05/05 18:34 [pubmed] PHST- 2025/05/05 13:33 [entrez] PHST- 2025/05/05 00:00 [pmc-release] AID - PONE-D-24-21888 [pii] AID - 10.1371/journal.pone.0322882 [doi] PST - epublish SO - PLoS One. 2025 May 5;20(5):e0322882. doi: 10.1371/journal.pone.0322882. eCollection 2025. PMID- 40323639 OWN - NLM STAT- MEDLINE DCOM- 20250903 LR - 20260617 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) VI - 36 IP - 6 DP - 2025 Sep 1 TI - Predicting Postoperative Prognosis in Pediatric Malignant Tumor With MRI Radiomics and Deep Learning Models: A Retrospective Study. PG - 1929-1935 LID - 10.1097/SCS.0000000000011466 [doi] AB - OBJECTIVE: The aim of this study is to develop a multimodal machine learning model that integrates magnetic resonance imaging (MRI) radiomics, deep learning features, and clinical indexes to predict the 3-year postoperative disease-free survival (DFS) in pediatric patients with malignant tumors. METHODS: A cohort of 260 pediatric patients with brain tumors who underwent R0 resection (aged /= 5 cm and preoperative low albumin, significantly contributed to prognosis prediction. CONCLUSION: The multimodal model demonstrated effective prediction of the 3-year postoperative DFS in pediatric brain tumors, offering a scientific foundation for personalized treatment. CI - Copyright (c) 2025 by Mutaz B. Habal, MD. FAU - Chen, Yao AU - Chen Y AD - Department of Anesthesiology, Sanbo Brain Hospital, Capital Medical University. AD - Department of Anesthesiology, Tsinghua University Yuquan Hospital. FAU - Hu, Xin AU - Hu X AD - Department of Critical Care Medicine, the First Medical Centre, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China. FAU - Fan, Ting AU - Fan T AD - Department of Anesthesiology, Tsinghua University Yuquan Hospital. FAU - Zhou, Yongde AU - Zhou Y AD - Department of Anesthesiology, Tsinghua University Yuquan Hospital. FAU - Yu, Cuiping AU - Yu C AD - Department of Anesthesiology, Tsinghua University Yuquan Hospital. FAU - Yu, Jianfeng AU - Yu J AD - Department of Anesthesiology, Tsinghua University Yuquan Hospital. FAU - Zhou, Xuan AU - Zhou X AD - Department of Anesthesiology, Tsinghua University Yuquan Hospital. FAU - Wang, Baoguo AU - Wang B AD - Department of Anesthesiology, Sanbo Brain Hospital, Capital Medical University. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250505 PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 SB - IM MH - Humans MH - Retrospective Studies MH - *Magnetic Resonance Imaging/methods MH - Child MH - Male MH - *Deep Learning MH - Female MH - *Brain Neoplasms/surgery/diagnostic imaging/mortality/pathology MH - Adolescent MH - Prognosis MH - Child, Preschool MH - Infant MH - Disease-Free Survival MH - Radiomics OTO - NOTNLM OT - Deep learning OT - disease-free survival OT - multimodal model OT - pediatric brain tumor OT - radiomics COIS- The authors report no conflicts of interest. EDAT- 2025/05/05 12:41 MHDA- 2025/09/04 00:35 CRDT- 2025/05/05 11:44 PHST- 2025/03/31 00:00 [received] PHST- 2025/04/09 00:00 [accepted] PHST- 2025/09/04 00:35 [medline] PHST- 2025/05/05 12:41 [pubmed] PHST- 2025/05/05 11:44 [entrez] AID - 00001665-990000000-02700 [pii] AID - 10.1097/SCS.0000000000011466 [doi] PST - ppublish SO - J Craniofac Surg. 2025 Sep 1;36(6):1929-1935. doi: 10.1097/SCS.0000000000011466. Epub 2025 May 5. PMID- 40320516 OWN - NLM STAT- MEDLINE DCOM- 20250505 LR - 20260625 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 25 IP - 1 DP - 2025 May 5 TI - Determinants of physical activity level in pediatric oncological patients treated with cardiotoxic therapy - a study protocol. PG - 355 LID - 10.1186/s12887-025-05714-5 [doi] LID - 355 AB - BACKGROUND: Childhood cancer and its therapy, especially that involving potentially cardiotoxic cancer treatment, can structurally affect muscle strength and heart function, and therefore may result in lowered physical activity (PA). This study protocol aims to find the significant determinants of PA levels in pediatric oncological patients 1-5 years after heart-toxic chemotherapy and/or radiation of the heart region. METHODS: The study group will include children 1-5 years after completing cancer therapy involving cardiotoxicity risk factors. The primary outcome of interest is the PA measured with an ActiGraph GT3X Accelerometer for 14 consecutive days and the assessment of WHO pediatric age-adjusted PA norms achievement. Assessed PA levels will be evaluated according to the possible determinants of PA: disease/treatment related risk factors, treatment complications, possible complications after the treatment, cardiac function with echocardiography including 2D and 3D strain imaging, physical function and muscle strength in ALPHA (Assessing Levels of Physical Activity) health-related fitness test battery and exercise capacity in cardiopulmonary exercise testing. The self-efficacy and motivation to PA, quality of life (QoL), lifestyle, socio-demographic, and anthropogenic factors as well as knowledge about the positive impact of PA will be evaluated with original and validated questionnaires. The PA determinants of the study group will be compared to the results of the control group of children in the same follow-up period (> 1 year < 5 years) after completing cancer therapy without cardiotoxic methods. DISCUSSION: The results may contribute to the development of future recommendations on prophylactic and therapeutic approaches, as well as proper lifestyle recommendations for children in long-term follow-up after cardiotoxic cancer therapy. The determinants will be used to develop targeted exercise prescriptions and exercise programs. TRIAL REGISTRATION: NCT06256068. CI - (c) 2025. The Author(s). FAU - Haponiuk-Skwarlinska, Julia AU - Haponiuk-Skwarlinska J AD - Department of Pediatric Cardiology and General Pediatrics, Doctoral School, Medical University of Warsaw, Zwirki i Wigury 63 A, Warsaw, 02-091, Poland. FAU - Gasior, Jakub S AU - Gasior JS AD - Department of Pediatric Cardiology and General Pediatrics, Medical University of Warsaw, Zwirki i Wigury 63 A, Warsaw, 02-091, Poland. jakub.gasior@wum.edu.pl. FAU - Albrecht, Katarzyna AU - Albrecht K AD - Department of Pediatrics, Oncology, Hematology and Transplantology, Medical University of Warsaw, Zwirki i Wigury 63 A, Warsaw, 02-091, Poland. FAU - Laguna, Pawel AU - Laguna P AD - Department of Pediatrics, Oncology, Hematology and Transplantology, Medical University of Warsaw, Zwirki i Wigury 63 A, Warsaw, 02-091, Poland. FAU - Werner, Bozena AU - Werner B AD - Department of Pediatric Cardiology and General Pediatrics, Medical University of Warsaw, Zwirki i Wigury 63 A, Warsaw, 02-091, Poland. LA - eng SI - ClinicalTrials.gov/NCT06256068 PT - Clinical Trial Protocol PT - Journal Article DEP - 20250505 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 RN - 0 (Antineoplastic Agents) SB - IM MH - Humans MH - *Exercise MH - Child MH - *Neoplasms/therapy/drug therapy MH - *Cardiotoxicity/etiology MH - Quality of Life MH - *Antineoplastic Agents/adverse effects MH - Child, Preschool MH - Female MH - Male MH - *Heart/radiation effects/drug effects MH - Risk Factors MH - Infant PMC - PMC12051312 OTO - NOTNLM OT - Cardiotoxicity OT - Childhood cancer OT - Exercise capacity OT - Pediatric oncology OT - Physical activity COIS- Declarations. Ethics approval and consent to participate: This study will be conducted according to the guidelines laid down in the Declaration of Helsinki and all procedures involving patients are approved by the local Ethic Examining Committee of Human Research of the Medical University of Warsaw (Decision of Approval: KB/54/A2023). Informed consent will be obtained from all subjects involved in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/05/05 00:27 MHDA- 2025/05/05 06:27 PMCR- 2025/05/05 CRDT- 2025/05/04 23:22 PHST- 2024/07/28 00:00 [received] PHST- 2025/04/24 00:00 [accepted] PHST- 2025/05/05 06:27 [medline] PHST- 2025/05/05 00:27 [pubmed] PHST- 2025/05/04 23:22 [entrez] PHST- 2025/05/05 00:00 [pmc-release] AID - 10.1186/s12887-025-05714-5 [pii] AID - 5714 [pii] AID - 10.1186/s12887-025-05714-5 [doi] PST - epublish SO - BMC Pediatr. 2025 May 5;25(1):355. doi: 10.1186/s12887-025-05714-5. PMID- 40316134 OWN - NLM STAT- MEDLINE DCOM- 20251205 LR - 20261006 IS - 2213-2961 (Electronic) IS - 2095-2546 (Print) IS - 2213-2961 (Linking) VI - 14 DP - 2025 Dec TI - The validity of automatic methods for estimating maturation stage in young athletes: A comparison of the Maturo smartphone application and sport science expert evaluations. PG - 101046 LID - S2095-2546(25)00024-9 [pii] LID - 10.1016/j.jshs.2025.101046 [doi] LID - 101046 AB - BACKGROUND: Biological maturation refers to the progressive process through which individuals transition toward an adult state during growth and development. To address the challenges posed by differences in biological maturity and the limitations of existing testing methods, particularly in adolescent sports contexts, there is a pressing need for a non-invasive method that is convenient, accurate, and broadly applicable to monitor the biological maturity of adolescent athletes comprehensively. In response to this need, a maturity assessment method based on the smartphone application Maturo has been developed. This study evaluates the accuracy and validity of the Maturo software, an automated tool for estimating biological age and related maturation metrics. METHODS: A sample of 103 actively training teenage athletes aged 9 - 17 years. The sample included 76 males (age = 11.74 +/- 1.55 years, mean +/- SD) and 27 females (age = 13.95 +/- 1.40 years), all without medical conditions that might impact growth or development. RESULTS: Compared to traditional expert evaluations, the intraclass correlation coefficients (ICCs) and Pearson correlation coefficients demonstrated reliable positive correlations and significant agreement between the Maturo software and expert methods across multiple metrics, such as biological age (ICC = 0.965, R = 0.97), corrected biological age (ICC = 0.973, R = 0.99), predicted adult height (ICC = 0.991, R = 0.99), and percentage of adult height achieved (ICC = 0.955, R = 0.97). The Bland-Altman plots provided additional evidence of the validity of the Maturo software estimations, showing low systematic error in most measures. The linear regression analysis produced excellent adjusted R(2) values: 0.95 for biological age and 0.99 for anticipated adult height. The Maturo approach demonstrated a high level of dependability in classifying teenagers into groups based on their maturity status and timing. The kappa coefficients of 0.93 for maturity status and 0.82 for maturity timing indicate a nearly perfect agreement with the expert technique. CONCLUSION: While the Maturo software's non-invasive nature, cost-effectiveness, and ease of use could make it a potential tool for regular monitoring of growth and maturation in young athletes, its promising results in assessing maturation should be interpreted with caution due to limitations such as sample size and demographic constraints. Further longitude research with larger and more diverse populations is needed to validate these preliminary findings and strengthen the evidence for its broader applicability. CI - Copyright (c) 2025. Production and hosting by Elsevier B.V. FAU - Shang, Ximing AU - Shang X AD - Department of Sports, Exercise and Health Sciences, University of Tras-os-Montes and Alto Douro, Vila Real 5000-801, Portugal; Research Center in Sport, Health, and Human Development (CIDESD), Vila Real 5000-801, Portugal. FAU - Arede, Jorge AU - Arede J AD - Department of Sports, Exercise and Health Sciences, University of Tras-os-Montes and Alto Douro, Vila Real 5000-801, Portugal; Research Center in Sport, Health, and Human Development (CIDESD), Vila Real 5000-801, Portugal; Escola Superior de Educacao de Viseu, Viseu 3500-155, Portugal. FAU - Couto, Pedro AU - Couto P AD - Department of Engineering, University of Tras-os-Montes and Alto Douro, Vila Real 5000-801, Portugal; Institute for Innovation, Capacity Building and Sustainability of Agri-Food Production (Inov4Agro), Vila Real 5000-801, Portugal; Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Vila Real 5000-801, Portugal. FAU - Leite, Nuno AU - Leite N AD - Department of Sports, Exercise and Health Sciences, University of Tras-os-Montes and Alto Douro, Vila Real 5000-801, Portugal; Research Center in Sport, Health, and Human Development (CIDESD), Vila Real 5000-801, Portugal. Electronic address: nleite@utad.pt. LA - eng PT - Comparative Study PT - Journal Article PT - Validation Study DEP - 20250430 PL - China TA - J Sport Health Sci JT - Journal of sport and health science JID - 101606001 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - *Smartphone MH - *Mobile Applications MH - Child MH - Reproducibility of Results MH - *Athletes MH - *Adolescent Development MH - Software PMC - PMC12268088 OTO - NOTNLM OT - Anthropometry OT - Biological maturation estimation OT - Maturation assessment OT - Maturo software OT - Youth athletes COIS- The authors declare that they have no competing interests. EDAT- 2025/05/03 00:37 MHDA- 2025/12/05 06:27 PMCR- 2025/04/30 CRDT- 2025/05/02 19:36 PHST- 2024/07/01 00:00 [received] PHST- 2024/11/16 00:00 [revised] PHST- 2025/01/07 00:00 [accepted] PHST- 2025/12/05 06:27 [medline] PHST- 2025/05/03 00:37 [pubmed] PHST- 2025/05/02 19:36 [entrez] PHST- 2025/04/30 00:00 [pmc-release] AID - S2095-2546(25)00024-9 [pii] AID - 101046 [pii] AID - 10.1016/j.jshs.2025.101046 [doi] PST - ppublish SO - J Sport Health Sci. 2025 Dec;14:101046. doi: 10.1016/j.jshs.2025.101046. Epub 2025 Apr 30. PMID- 40316033 OWN - NLM STAT- MEDLINE DCOM- 20250723 LR - 20250723 IS - 1090-2139 (Electronic) IS - 0889-1591 (Linking) VI - 128 DP - 2025 Aug TI - Role of early life adversities in inflammation-related neuropsychiatric comorbidity in obesity. PG - 612-619 LID - S0889-1591(25)00177-1 [pii] LID - 10.1016/j.bbi.2025.04.039 [doi] AB - A growing body of data highlights the key role of adiposity-related inflammation in the development of neuropsychiatric comorbidity in obesity. Nevertheless, despite similar levels of inflammation, only a subgroup of obese subjects is afflicted with neuropsychiatric symptoms, suggesting the contribution of additional vulnerability factors. In light of previous work suggesting the involvement of early life adversity (ELA), this study aims to determine whether ELA promotes the emergence of inflammation-related neuropsychiatric symptoms in a sample of obese subjects. Eighty-two adults afflicted with obesity (BMI > 30 kg/m(2)) and twenty-one lean individuals (BMI < 25 kg/m(2)) were recruited. Depressive symptoms, fatigue and neurobehavioral symptoms were assessed through semi-structured interviews and validated self-reports. ELA was measured using the Childhood Trauma Questionnaire (CTQ). Systemic inflammation was determined through serum concentrations of high-sensitivity C-reactive protein (hsCRP). In the whole population under study, hsCRP concentrations were significantly associated with neuropsychiatric symptoms, consistent with the increased prevalence of neuropsychiatric comorbidity in obese subjects. Significant associations were also found between ELA severity and neuropsychiatric symptoms. Although they did not influence hsCRP levels, ELA antecedents in obese subjects were associated with more marked mood, fatigue and cognitive symptoms. Among ELA, sexual abuse was the only significant predictor of the association between hsCRP levels and neuropsychiatric comorbidity in obesity. These findings support the hypothesis that ELA represents a potent vulnerability factor for the development of neuropsychiatric comorbidity in obese subjects with chronic inflammation. CI - Copyright (c) 2025 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Montet, Juliette AU - Montet J AD - Univ. Bordeaux, INRAE, Bordeaux INP, NutriNeurO, UMR 1286, Bordeaux, France. FAU - Dexpert, Sandra AU - Dexpert S AD - Univ. Bordeaux, INRAE, Bordeaux INP, NutriNeurO, UMR 1286, Bordeaux, France. FAU - Darnaudery, Muriel AU - Darnaudery M AD - Univ. Bordeaux, INRAE, Bordeaux INP, NutriNeurO, UMR 1286, Bordeaux, France. FAU - Beau, Cedric AU - Beau C AD - Service de Chirurgie Digestive et Parietale, Clinique Tivoli, 33000 Bordeaux, and clinique Jean Villar, 33520 Bruges, France. FAU - Forestier, Damien AU - Forestier D AD - Service de Chirurgie Digestive et Parietale, Clinique Tivoli, 33000 Bordeaux, and clinique Jean Villar, 33520 Bruges, France. FAU - Ledaguenel, Patrick AU - Ledaguenel P AD - Service de Chirurgie Digestive et Parietale, Clinique Tivoli, 33000 Bordeaux, and clinique Jean Villar, 33520 Bruges, France. FAU - Magne, Eric AU - Magne E AD - Service de Chirurgie Digestive et Parietale, Clinique Tivoli, 33000 Bordeaux, and clinique Jean Villar, 33520 Bruges, France. FAU - Aouizerate, Bruno AU - Aouizerate B AD - Univ. Bordeaux, INRAE, Bordeaux INP, NutriNeurO, UMR 1286, Bordeaux, France; CH Charles Perrens, Pole de Psychiatrie Generale et Universitaire, Centre de reference regional des pathologies anxieuses et depressives, Centre Expert Depression Resistante FondaMental, Bordeaux, France. FAU - Capuron, Lucile AU - Capuron L AD - Univ. Bordeaux, INRAE, Bordeaux INP, NutriNeurO, UMR 1286, Bordeaux, France. Electronic address: lucile.capuron@inrae.fr. LA - eng PT - Journal Article DEP - 20250430 PL - Netherlands TA - Brain Behav Immun JT - Brain, behavior, and immunity JID - 8800478 RN - 9007-41-4 (C-Reactive Protein) SB - IM MH - Humans MH - Male MH - Female MH - *Obesity/psychology/epidemiology/complications MH - *Inflammation/psychology MH - Adult MH - Comorbidity MH - Middle Aged MH - *Adverse Childhood Experiences MH - C-Reactive Protein/metabolism/analysis MH - Fatigue MH - Depression/epidemiology MH - *Mental Disorders/epidemiology OTO - NOTNLM OT - Early Life Adversities OT - Inflammation OT - Neuropsychiatric Symptoms OT - Obesity OT - Stress OT - Trauma COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/05/03 00:37 MHDA- 2025/07/24 00:25 CRDT- 2025/05/02 19:35 PHST- 2025/02/07 00:00 [received] PHST- 2025/04/01 00:00 [revised] PHST- 2025/04/28 00:00 [accepted] PHST- 2025/07/24 00:25 [medline] PHST- 2025/05/03 00:37 [pubmed] PHST- 2025/05/02 19:35 [entrez] AID - S0889-1591(25)00177-1 [pii] AID - 10.1016/j.bbi.2025.04.039 [doi] PST - ppublish SO - Brain Behav Immun. 2025 Aug;128:612-619. doi: 10.1016/j.bbi.2025.04.039. Epub 2025 Apr 30. PMID- 40314341 OWN - NLM STAT- MEDLINE DCOM- 20250507 LR - 20260716 IS - 2047-9980 (Electronic) IS - 2047-9980 (Linking) VI - 14 IP - 9 DP - 2025 May 6 TI - Circulating 25-Hydroxyvitamin D Levels During Pregnancy and Risk of Congenital Heart Diseases: Multivariable and Mendelian Randomization Analyses Using 3 Birth Cohorts. PG - e036273 LID - 10.1161/JAHA.124.036273 [doi] LID - e036273 AB - BACKGROUND: Identifying modifiable risk factors for congenital heart disease (CHD) is important for prevention. Previous studies have reported associations between 25-hydroxyvitamin D (25(OH)D) in pregnancy and CHD in the offspring. However, these studies contain important methodological limitations. We aimed to investigate 25(OH)D levels during pregnancy in relation to offspring risk of CHD using both multivariable regression (MVR) analysis and Mendelian randomization (MR) analysis. METHODS: Data from the ALSPAC (Avon Longitudinal Study of Parents and Children), BiB (Born in Bradford), and MoBa (Norwegian Mother, Father and Child Cohort) studies (N=8722 (77 cases) for MVR analysis, N=74 953 (646 cases) for MR) were used. MVR analysis was adjusted for offspring sex, maternal age, education, body mass index, smoking, alcohol consumption, and parity. One sample MR was performed with weighted genetic risk score for 25(OH)D based on published genome-wide significant genetic variants. Sensitivity analyses explored the relevance and validity of the genetic risk score. Results were pooled across the 3 cohorts in a meta-analysis with random effects and consistency between results from the MVR and MR was examined. RESULTS: Pooled results from the adjusted MVR suggested higher maternal pregnancy 25(OH)D associated with lower CHD risk, though the CIs were wide and included the null (odds ratio [OR], 0.79 [95% CI, 0.53, 1.06] per 1 SD higher 25(OH)D). By contrast precise MR results did not support a causal relationship (OR, 0.99 [95% CI, 0.91, 1.07] per 1 SD higher 25(OH)D genetic risk score). CONCLUSIONS: We did not find robust evidence supporting an effect of maternal pregnancy 25(OH)D levels on offspring CHD. FAU - Walker, Karen Christina AU - Walker KC AUID- ORCID: 0000-0001-9867-1416 AD - The Parker Institute, Research Unit for Dietary studies Bispebjerg and Frederiksberg Hospital Frederiksberg Denmark. FAU - Specht, Ina O AU - Specht IO AUID- ORCID: 0000-0002-3114-4715 AD - The Parker Institute, Research Unit for Dietary studies Bispebjerg and Frederiksberg Hospital Frederiksberg Denmark. AD - The Research Unit for General Practice and Section of General Practice, Department of Public Health University of Copenhagen Denmark. FAU - Hjortdal, Vibeke AU - Hjortdal V AUID- ORCID: 0000-0002-8047-0015 AD - Department of Cardiothoracic Surgery Rigshospitalet Copenhagen Denmark. FAU - Christesen, Henrik T AU - Christesen HT AUID- ORCID: 0000-0001-5330-6853 AD - Institute of Clinical Research University of Southern Denmark Odense Denmark. AD - Hans Christian Andersen Children's Hospital Odense University Hospital Odense Denmark. FAU - Heitmann, Berit L AU - Heitmann BL AUID- ORCID: 0000-0002-6809-4504 AD - The Parker Institute, Research Unit for Dietary studies Bispebjerg and Frederiksberg Hospital Frederiksberg Denmark. AD - The Research Unit for General Practice and Section of General Practice, Department of Public Health University of Copenhagen Denmark. AD - The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders The University of Sydney Australia. FAU - Santorelli, Gillian AU - Santorelli G AUID- ORCID: 0000-0003-0427-1783 AD - Bradford Institute for Health Research Bradford UK. FAU - West, Jane AU - West J AUID- ORCID: 0000-0002-5770-8363 AD - Bradford Institute for Health Research Bradford UK. FAU - Magnus, Per AU - Magnus P AUID- ORCID: 0000-0002-6427-4735 AD - Centre for Fertility and Health Norwegian Institute of Public Health Oslo Norway. FAU - Njolstad, Pal R AU - Njolstad PR AUID- ORCID: 0000-0003-0304-6728 AD - Mohn Center for Diabetes Precision Medicine, Department of Clinical Science University of Bergen Norway. AD - Department of Pediatrics and Adolescents Haukeland University Hospital Bergen Norway. FAU - Corfield, Elizabeth C AU - Corfield EC AUID- ORCID: 0000-0002-0119-157X AD - PsychGen Centre for Genetic Epidemiology and Mental Health Norwegian Institute of Public Health Oslo Norway. AD - Nic Waals Institute, Lovisenberg Diakonale Hospital Oslo Norway. FAU - Havdahl, Alexandra AU - Havdahl A AD - PsychGen Centre for Genetic Epidemiology and Mental Health Norwegian Institute of Public Health Oslo Norway. AD - Nic Waals Institute, Lovisenberg Diakonale Hospital Oslo Norway. AD - PROMENTA Research Center, Department of Psychology University of Oslo Norway. FAU - Magnus, Maria AU - Magnus M AD - Centre for Fertility and Health Norwegian Institute of Public Health Oslo Norway. FAU - Taylor, Kurt AU - Taylor K AUID- ORCID: 0000-0003-4690-063X AD - Population Health Science, Bristol Medical School Bristol UK. AD - MRC Integrative Epidemiology Unit at the University of Bristol UK. FAU - Lawlor, Deborah A AU - Lawlor DA AUID- ORCID: 0000-0002-6793-2262 AD - Population Health Science, Bristol Medical School Bristol UK. AD - MRC Integrative Epidemiology Unit at the University of Bristol UK. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250502 PL - England TA - J Am Heart Assoc JT - Journal of the American Heart Association JID - 101580524 RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Pregnancy MH - Mendelian Randomization Analysis MH - *Vitamin D/analogs & derivatives/blood MH - *Heart Defects, Congenital/blood/genetics/epidemiology/diagnosis MH - Risk Factors MH - Adult MH - Male MH - Risk Assessment MH - Biomarkers/blood MH - Birth Cohort MH - *Vitamin D Deficiency/blood/epidemiology/diagnosis MH - Multivariate Analysis PMC - PMC12184255 OTO - NOTNLM OT - 25(OH)D; multivariable regression analysis OT - ALSPAC OT - BiB OT - Mendelian randomization OT - MoBa OT - congenital heart disease COIS- None. EDAT- 2025/05/02 12:32 MHDA- 2025/05/07 12:31 PMCR- 2025/05/02 CRDT- 2025/05/02 08:03 PHST- 2025/05/07 12:31 [medline] PHST- 2025/05/02 12:32 [pubmed] PHST- 2025/05/02 08:03 [entrez] PHST- 2025/05/02 00:00 [pmc-release] AID - JAH310903 [pii] AID - 10.1161/JAHA.124.036273 [doi] PST - ppublish SO - J Am Heart Assoc. 2025 May 6;14(9):e036273. doi: 10.1161/JAHA.124.036273. Epub 2025 May 2. PMID- 40313895 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250503 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 16 DP - 2025 TI - Development and preliminary validation of a Chinese Physical Activity Parenting Practices Scale (3-6 years). PG - 1560244 LID - 10.3389/fpsyg.2025.1560244 [doi] LID - 1560244 AB - BACKGROUND: This study aimed to develop a scale to assess the physical activity (PA)-related parenting practices of Chinese parents of children aged 3-6 years based on general parenting theory. METHODS: A pool of scale items (123 items) was constructed based on a literature review and in-depth personal interviews. The pretest scale (60 items) was developed using Delphi correspondence and a presurvey. After two rounds of item screening of the pretest scale using exploratory factor analysis (EFA) and analysis of variance, we deleted 30 items. We ultimately developed a formal version of the Chinese Physical Activity Parenting Practices Scale (CPAPPS) using the remaining 30 items. We examined the structure of the scale using factor analysis and evaluated its reliability, validity, and discriminant ability using data from 899 parents of children aged 3-6 years. RESULTS: The CPAPPS includes 30 items in 6 dimensions scored on a 5-point Likert scale. The 6 dimensions are education, autonomy promotion, modeling, demands, expectations, and rewards. Both exploratory and confirmatory factor analyses confirmed the construct validity of the scale. Furthermore, the scale had adequate internal consistency, split-half reliability, test-retest reliability, and concurrent validity. Parents younger than 30 scored significantly lower on the demand dimension than parents aged 40-50 (p < 0.05). The differences in rewards and expectations between parents of different ethnicities were statistically significant (p < 0.05). Compared with married parents, parents who were currently single had lower scores for education, rewards, modeling, and autonomy promotion (p < 0.05). There was a significant difference in scores across all dimensions between parents with different places of residence (p < 0.05). CONCLUSION: The CPAPPS satisfies the conditions for reliability and validity in accordance with psychometric requirements. The scale can be employed to evaluate the characteristics of Chinese parents' physical activity-related parenting practices and to design family-based PA interventions. CI - Copyright (c) 2025 Na, Liang, Zhang, Yang, Li, Zhang, Tang, Ye, Zhang, Jiang and Shang. FAU - Na, Ren AU - Na R AD - Department of Health Statistics, School of Public Health, Air Force Military Medical University, Xi'an, China. FAU - Liang, Ying AU - Liang Y AD - Department of Health Statistics, School of Public Health, Air Force Military Medical University, Xi'an, China. FAU - Zhang, Haiyue AU - Zhang H AD - Department of Health Statistics, School of Public Health, Air Force Military Medical University, Xi'an, China. FAU - Yang, Zhe AU - Yang Z AD - Department of Health Statistics, School of Public Health, Air Force Military Medical University, Xi'an, China. FAU - Li, Nan AU - Li N AD - Department of Health Statistics, School of Public Health, Air Force Military Medical University, Xi'an, China. FAU - Zhang, Wei AU - Zhang W AD - Department of Health Statistics, School of Public Health, Air Force Military Medical University, Xi'an, China. FAU - Tang, Han AU - Tang H AD - Department of Health Statistics, School of Public Health, Air Force Military Medical University, Xi'an, China. FAU - Ye, Weiliang AU - Ye W AD - Department of Pharmacy and Pharmaceutical Management, Air Force Military Medical University, Xi'an, China. FAU - Zhang, Linyuan AU - Zhang L AD - School of Nursing, Air Force Military Medical University, Xi'an, China. FAU - Jiang, Xun AU - Jiang X AD - Department of Pediatrics, Tangdu Hospital, Air Force Military Medical University, Xi'an, China. FAU - Shang, Lei AU - Shang L AD - Department of Health Statistics, School of Public Health, Air Force Military Medical University, Xi'an, China. LA - eng PT - Journal Article DEP - 20250417 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC12043650 OTO - NOTNLM OT - children OT - measurement OT - parents OT - physical activity OT - reliability OT - validity COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/05/02 06:27 MHDA- 2025/05/02 06:28 PMCR- 2025/04/17 CRDT- 2025/05/02 04:31 PHST- 2025/01/14 00:00 [received] PHST- 2025/04/03 00:00 [accepted] PHST- 2025/05/02 06:28 [medline] PHST- 2025/05/02 06:27 [pubmed] PHST- 2025/05/02 04:31 [entrez] PHST- 2025/04/17 00:00 [pmc-release] AID - 10.3389/fpsyg.2025.1560244 [doi] PST - epublish SO - Front Psychol. 2025 Apr 17;16:1560244. doi: 10.3389/fpsyg.2025.1560244. eCollection 2025. PMID- 40312836 OWN - NLM STAT- MEDLINE DCOM- 20250904 LR - 20260629 IS - 1476-6256 (Electronic) IS - 0002-9262 (Linking) VI - 194 IP - 9 DP - 2025 Sep 3 TI - Reproducibility and validity of low-carbohydrate diet and low-fat diet scores derived from 24-hour dietary recalls. PG - 2724-2732 LID - 10.1093/aje/kwaf087 [doi] AB - The reproducibility and validity of low-carbohydrate diets (LCD) and low-fat diets (LFD) from 24-hour dietary recall (24HDR) remain unclear. We evaluated the performance of 24HDR-based assessments of 6 dietary patterns (overall, healthful, and unhealthful LCD/LFD) to determine the optimum number of 24HDR in epidemiologic studies. Participants (n = 432, 185 men and 247 women) aged 18-84 years from the Anhui Lifestyle Validation Study (ALVS) completed 4 quarterly 3 consecutive 24HDRs (2 weekdays and 1 weekend day) during July 2021 to July 2022. Reproducibility was evaluated by intraclass correlation coefficient (ICC). Validity was evaluated by comparing the estimates against those from the average of 12 24HDRs using deattenuated Spearman correlation coefficient (rc). Reproducibility and validity increased with an escalating number of 24HDRs. Dietary pattern scores from 2 24HDRs showed moderate reproducibility (ICC: 0.40-0.47), except unhealthful LFD with the ICC of 0.37, while 4 24HDRs yielded a moderate reproducibility for all dietary patterns (ICC: 0.43-0.59). The validity of the 6 dietary patterns was moderate for 1 24HDR (rc: 0.44-0.58) and moderate or strong for >/=2 24HDRs (rc: 0.56-0.98). Two 24HDRs show reasonable performance in measuring most LCD/LFD scores, and 4 24HDRs are sufficient for all dietary patterns. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Li, Meiling AU - Li M AUID- ORCID: 0009-0000-1052-8501 AD - Department of Nutrition, Center for Big Data and Population Health of IHM, School of Public Health, Anhui Medical University, Hefei, Anhui, China. AD - Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, Hefei, Anhui, China. AD - NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, National Health Commission of the People's Republic of China, Hefei, Anhui, China. AD - Anhui Provincial Key Laboratory of Population Health and Aristogenics/Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei, Anhui, China. FAU - Li, Xiude AU - Li X AUID- ORCID: 0000-0002-3475-7015 AD - Department of Clinical Nutrition, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Yin, Kewan AU - Yin K AUID- ORCID: 0009-0002-7918-6807 AD - Department of Nutrition, Center for Big Data and Population Health of IHM, School of Public Health, Anhui Medical University, Hefei, Anhui, China. FAU - Wang, Tingting AU - Wang T AUID- ORCID: 0009-0009-3521-2445 AD - Department of Nutrition, Center for Big Data and Population Health of IHM, School of Public Health, Anhui Medical University, Hefei, Anhui, China. FAU - Jiang, Chao AU - Jiang C AUID- ORCID: 0009-0004-6243-4565 AD - Department of Chronic Non-communicable Diseases Prevention and Control, Huoshan County Center for Disease Control and Prevention, Huoshan, Anhui, China. FAU - Cao, Hongjuan AU - Cao H AUID- ORCID: 0009-0004-1664-289X AD - Department of Chronic Non-communicable Diseases Prevention and Control, Lu'an Center for Disease Control and Prevention, Lu'an, Anhui, China. FAU - Zhang, Zhuang AU - Zhang Z AUID- ORCID: 0009-0004-1144-9740 AD - Department of Nutrition, Center for Big Data and Population Health of IHM, School of Public Health, Anhui Medical University, Hefei, Anhui, China. FAU - Sun, Jiangwei AU - Sun J AUID- ORCID: 0000-0003-2252-684X AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Yang, Wanshui AU - Yang W AUID- ORCID: 0000-0002-7365-2689 AD - Department of Nutrition, Center for Big Data and Population Health of IHM, School of Public Health, Anhui Medical University, Hefei, Anhui, China. AD - Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, Hefei, Anhui, China. AD - NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, National Health Commission of the People's Republic of China, Hefei, Anhui, China. AD - Anhui Provincial Key Laboratory of Population Health and Aristogenics/Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei, Anhui, China. LA - eng GR - YJS20230150/Postgraduate Innovation Research and Practice Program of Anhui Medical University/ GR - YJS20230104/Postgraduate Innovation Research and Practice Program of Anhui Medical University/ GR - 2021xkjT007/Anhui Medical University/ GR - JKS2022018/Research Funds of Center for Big Data and Population Health of IHM/ GR - 82373673/National Natural Science Foundation of China/ GR - 2023YFA1800800/National Key Research and Development Program of China/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study PL - United States TA - Am J Epidemiol JT - American journal of epidemiology JID - 7910653 SB - IM MH - Humans MH - Middle Aged MH - Male MH - Female MH - Reproducibility of Results MH - Adult MH - Aged MH - *Diet, Carbohydrate-Restricted/statistics & numerical data MH - Aged, 80 and over MH - Adolescent MH - Young Adult MH - *Diet, Fat-Restricted/statistics & numerical data MH - *Mental Recall MH - *Diet Surveys OTO - NOTNLM OT - 24-hour dietary recall OT - low-carbohydrate diet OT - low-fat diet OT - reproducibility OT - validity EDAT- 2025/05/02 06:28 MHDA- 2025/09/04 06:37 CRDT- 2025/05/02 00:53 PHST- 2024/07/04 00:00 [received] PHST- 2025/04/08 00:00 [revised] PHST- 2025/04/15 00:00 [accepted] PHST- 2025/09/04 06:37 [medline] PHST- 2025/05/02 06:28 [pubmed] PHST- 2025/05/02 00:53 [entrez] AID - 8123640 [pii] AID - 10.1093/aje/kwaf087 [doi] PST - ppublish SO - Am J Epidemiol. 2025 Sep 3;194(9):2724-2732. doi: 10.1093/aje/kwaf087. PMID- 40312425 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250503 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 13 IP - 1 DP - 2025 May 1 TI - The weight of words: investigating the role of weight stigma and body mass index in shaping children and youth's emotional experiences. PG - 73 LID - 10.1186/s40337-025-01248-4 [doi] LID - 73 AB - BACKGROUND: The prevalence of overweight and obesity among children and adolescents has become a significant public health concern worldwide. These conditions not only affect physical health but also contribute to psychological challenges, particularly through weight stigma. Understanding the relationship between weight stigma, body mass index (BMI), and emotional distress is crucial for informing interventions, particularly in cultural contexts where weight-related perceptions vary. AIM: This study aimed to investigate the influence of weight stigma and BMI on the emotional experiences of children and youth in Egypt. METHODS: A descriptive correlational design was employed in 16 preparatory schools, 49 secondary schools, and 20 faculties across various Egyptian governorates. A convenience sample of 2,731 participants aged 12-21 years was included. Data were collected using an online questionnaire that measured BMI, weight stigma, and emotional states (depression, anxiety, and stress) through validated tools. Statistical analyses included chi-square and linear regression tests. RESULTS: The findings revealed that 22% of participants experienced high levels of weight stigma, which was significantly associated with higher levels of emotional distress (p < 0.001). Weight stigma explained 46.9% of the variance in emotional distress, whereas BMI showed no significant association with emotional states (p = 0.983). Notably, cultural factors, including conflicting societal norms regarding body weight and media influence, appeared to shape weight perceptions and stigma experiences among youth. CONCLUSION: Weight stigma is a stronger predictor of emotional distress than BMI, emphasizing the need for targeted interventions addressing weight-based discrimination. Given the cultural nuances influencing weight perception in Egypt, public health initiatives should incorporate culturally sensitive approaches to promote body positivity and mitigate the psychological impact of stigma. These findings contribute to global eating disorder research by highlighting the role of sociocultural factors in shaping weight-related experiences among youth. CI - (c) 2025. The Author(s). FAU - Hendy, Abdelaziz AU - Hendy A AD - Pediatric Nursing, Faculty of Nursing, Ain Shams University, Cairo, Egypt. Abdelaziz.hendy@nursing.asu.edu.eg. FAU - Soliman, Sahar M AU - Soliman SM AD - Department of Maternal and Neonatal Health Nursing, Faculty of Nursing, Ain Shams University, Cairo, 11517, Egypt. FAU - Tantawi, Hyam AU - Tantawi H AD - Pediatric Nursing, Faculty of Nursing, Ain Shams University, Cairo, Egypt. FAU - Salman, Samira AU - Salman S AD - Psychiatric Mental Health Nursing, Faculty of Nursing, Ain Shams University, Cairo, Egypt. FAU - Ibrahim, Rasha Kadri AU - Ibrahim RK AD - Nursing Department, Fatima College of Health Sciences, Al Dhafra Region, Baynunah Complex, P.O. Box 50433, Madinat Zayed, UAE. FAU - Hendy, Ahmed AU - Hendy A AD - Department of Computational Mathematics and Computer Science, Institute of Natural Sciences and Mathematics, Ural Federal University, Yekaterinburg, Russian Federation, 620002. AD - Department of Mechanics and Mathematics, Western Caspian University, Baku, Azerbaijan. FAU - Fattah, Hadya Abboud Abdel AU - Fattah HAA AD - Nursing Department, Fatima College of Health Sciences, Abu Dhabi, UAE. FAU - Al-Mugheed, Khalid AU - Al-Mugheed K AD - Faculty of Nursing, Riyadh Elm University, Riyadh, Saudi Arabia. FAU - Sayed, Salwa AU - Sayed S AD - Clinical Instructor in Technical Health Institute at General Authority for Health Insurance, Benha, Egypt. FAU - Alabdullah, Amany Anwar Saeed AU - Alabdullah AAS AD - Department of Maternity and Pediatric Nursing, College of Nursing, Princess Nourah bint Abdulrahman University, P.O. Box 84428, 11671, Riyadh, Saudi Arabia. FAU - Abdelaliem, Sally Mohammed Farghaly AU - Abdelaliem SMF AD - Department of Nursing Management and Education, College of Nursing, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Zaher, Ahmed AU - Zaher A AD - Psychiatric Mental Health Nursing, Faculty of Nursing, Ain Shams University, Cairo, Egypt. LA - eng GR - PNURSP2024R444/Princess Nourah Bint Abdulrahman University/ PT - Journal Article DEP - 20250501 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC12044770 OAB - This study looked at how young people in Egypt feel about their bodies and how being treated differently because of their weight affects their emotions. The researchers wanted to understand whether being overweight or underweight (measured by Body Mass Index, or BMI) or being teased or judged for weight (called weight stigma) was more connected to feelings like stress, anxiety, or sadness. More than 2700 young people between the ages of 12 and 21 took part in the study. They answered questions about their height, weight, feelings, and whether they had experienced teasing or criticism about their bodies. The study found that nearly 1 in 5 participants experienced high levels of weight stigma. Those who felt more judged or teased about their weight were more likely to feel emotionally distressed. Surprisingly, actual weight (BMI) didn't have a meaningful link to emotional health; what mattered more was how others treated them because of their weight. Cultural attitudes in Egypt also played a big role. While some older adults see being heavier as a sign of health or wealth, younger people are more influenced by social media and Western beauty standards that promote thinness. This creates confusion and pressure for many young people. The findings highlight the importance of creating supportive environments in schools, families, and communities. Addressing teasing and promoting body acceptance could help protect young people's mental health, regardless of their body size. OABL- eng OTO - NOTNLM OT - Adolescents OT - Body mass index OT - Children OT - Emotional distress OT - Obesity OT - Weight stigma COIS- Declarations. Ethics approval and consent to participate: The ethics committee of the Faculty of Nursing at Ain Shams University reviewed and approved the study (study ID: 23.09.125). Prior to completing the questionnaire, written informed consent was obtained from all participants or their legal guardians. Participants were informed of the study's purpose and procedures, and were assured that all information gathered would be kept confidential. They were also informed of their right to withdraw from the study at any time without any consequences. The online survey was anonymous, ensuring that there was no risk to the participants. Additionally, written informed consent was obtained from the participants or their legal guardians for the publication of the study's findings. To address potential emotional distress, participants were provided with contact information for a licensed psychologist who was available to offer support. Participants were also reminded that they could discontinue their participation at any time, with no repercussions. Additionally, all survey responses were kept confidential and anonymous, with no personally identifiable information collected. Only aggregate data were used for analysis and publication, further safeguarding participants' privacy. Consent for publication: Not applicable. Competing interests: No competing interest. EDAT- 2025/05/02 00:27 MHDA- 2025/05/02 00:28 PMCR- 2025/05/01 CRDT- 2025/05/01 23:19 PHST- 2024/05/24 00:00 [received] PHST- 2025/03/24 00:00 [accepted] PHST- 2025/05/02 00:28 [medline] PHST- 2025/05/02 00:27 [pubmed] PHST- 2025/05/01 23:19 [entrez] PHST- 2025/05/01 00:00 [pmc-release] AID - 10.1186/s40337-025-01248-4 [pii] AID - 1248 [pii] AID - 10.1186/s40337-025-01248-4 [doi] PST - epublish SO - J Eat Disord. 2025 May 1;13(1):73. doi: 10.1186/s40337-025-01248-4. PMID- 40312331 OWN - NLM STAT- MEDLINE DCOM- 20250502 LR - 20250504 IS - 1546-0096 (Electronic) IS - 1546-0096 (Linking) VI - 23 IP - 1 DP - 2025 May 1 TI - Digital health tools in juvenile idiopathic arthritis: a systematic literature review. PG - 45 LID - 10.1186/s12969-025-01094-3 [doi] LID - 45 AB - BACKGROUND: Nowadays, digital health technologies, including mobile apps, wearable technologies, social media, websites, electronic medical records, and artificial intelligence, are impacting disease management and outcomes. We aimed to analyse the characteristics and use of digital health tools in juvenile idiopathic arthritis (JIA). METHODS: We conducted a systematic review (SR) to identify articles examining the characteristics, use, and outcomes (feasibility, usability, and effectiveness) of digital health tools in JIA patients. A sensitive search strategy was performed in Medline, Embase, and Cochrane databases until December 2022 (later updated to March 2024). Two reviewers independently selected the studies and collected the data, including study quality. A descriptive analysis was performed. RESULTS: A total of 21 studies were included, one SR, six randomised controlled trials, four observational studies, four validation studies, one discovery and verification study, and five qualitative studies. Study quality was generally moderate. Most studies focused on patients with JIA (especially young people), but also on parents and health care professionals. Different digital health technologies were investigated, like websites, mobile apps, wearables, and telemedicine. The main objectives of the tools were self-management, symptom and quality of life monitoring, physical activity tracking, disease knowledge improvement, and medication monitoring. Different themes and contents were usually included in the same digital health tool, such as psychological health, lifestyle, intimacy, or shared decision-making. Tool development and validation processes were poorly or not at all described, and data regarding regulatory compliance, security, or privacy were scarce. CONCLUSIONS: There is significant variability in the type, characteristics, objectives, and contents of digital health tools for JIA. They still show limitations and gaps, thus highlighting the need for better critical assessment and reporting. CI - (c) 2025. The Author(s). FAU - Anton, Jordi AU - Anton J AUID- ORCID: 0000-0002-8792-4219 AD - Department of Paediatric Rheumatology, Hospital Sant Joan de Deu, Barcelona, Spain. Jordi.anton@sjd.es. AD - Department of Surgery and Medical-Surgical Specialties, Obstetrics, Gynaecology and Paediatrics, Medicine and Health Sciences School, Universitat de Barcelona, Barcelona, Spain. Jordi.anton@sjd.es. FAU - Montoro, Maria AU - Montoro M AUID- ORCID: 0000-0002-1807-7044 AD - Pfizer Medical, Madrid, Alcobendas, Spain. FAU - Loza, Estibaliz AU - Loza E AUID- ORCID: 0000-0002-4607-9178 AD - Instituto de Salud Musculoesqueletica, Madrid, Spain. FAU - Oton, Teresa AU - Oton T AUID- ORCID: 0000-0003-3622-7146 AD - Instituto de Salud Musculoesqueletica, Madrid, Spain. FAU - Ramirez, Susan AU - Ramirez S AUID- ORCID: 0000-0002-5538-5126 AD - Pfizer Medical, Madrid, Alcobendas, Spain. FAU - Benavent, Diego AU - Benavent D AUID- ORCID: 0000-0001-9119-5330 AD - Department of Rheumatology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain. LA - eng PT - Journal Article PT - Systematic Review DEP - 20250501 PL - England TA - Pediatr Rheumatol Online J JT - Pediatric rheumatology online journal JID - 101248897 SB - IM MH - Humans MH - *Arthritis, Juvenile/therapy MH - Telemedicine MH - Mobile Applications MH - Quality of Life MH - Wearable Electronic Devices MH - Social Media MH - Child MH - Digital Health PMC - PMC12046958 OTO - NOTNLM OT - Digital health tools OT - Juvenile idiopathic arthritis OT - Systematic review COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: All authors read and approved the final manuscript and gave their consent for publication. Competing interests: Diego Benavent, Jordi Anton, Teresa Oton, and Estibaliz Loza, were paid as consultants by Pfizer for their involvement in the development of this manuscript and on the steering committee. Maria Montoro and Susan Ramirez are Pfizer employees. EDAT- 2025/05/02 00:27 MHDA- 2025/05/02 06:27 PMCR- 2025/05/01 CRDT- 2025/05/01 23:14 PHST- 2024/09/26 00:00 [received] PHST- 2025/04/11 00:00 [accepted] PHST- 2025/05/02 06:27 [medline] PHST- 2025/05/02 00:27 [pubmed] PHST- 2025/05/01 23:14 [entrez] PHST- 2025/05/01 00:00 [pmc-release] AID - 10.1186/s12969-025-01094-3 [pii] AID - 1094 [pii] AID - 10.1186/s12969-025-01094-3 [doi] PST - epublish SO - Pediatr Rheumatol Online J. 2025 May 1;23(1):45. doi: 10.1186/s12969-025-01094-3. PMID- 40312313 OWN - NLM STAT- MEDLINE DCOM- 20250502 LR - 20260625 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 25 IP - 1 DP - 2025 May 1 TI - Quality of life and physical activity in type 1 diabetes. PG - 345 LID - 10.1186/s12887-025-05632-6 [doi] LID - 345 AB - INTRODUCTION: T1 Diabetes (T1D) is one of the most common chronic diseases in children and young people [1] with almost 34 000 aged 18 years or less living with T1D [2]. Physical activity is promoted as one of a number of management tools for people living with diabetes, being associated with significant health benefits including improved glycaemic control. The benefits of physical activity on quality of life in children with T1D is unclear with confounding effects of disease duration and co-morbidities in studies. AIM: To determine the effect of physical activity interventions on quality of life of children with type 1 diabetes. METHODS: A systematic review was conducted and reported in line with PRISMA 2009 guidance. The CINAHL, Embase, International Pharmaceutical Abstracts, Medline, PubMed and PsychINFO databases were searched for the period January 1994 to March 2025. Papers were included in the present review if they included a study intervention in children under 19 years of age that was more than a single exercise session and had a control group (with or without T1D) as a comparator group. The primary outcome measure was Quality of Life (QoL) indicators. RESULTS: We assessed 3020 records, of which three randomised controlled trials (RCT) published between 2007 and 2020 met study inclusion criteria. There was significant heterogeneity in study design, methods and reporting. Benefits of physical activity were not consistently seen across studies. CONCLUSION: There remains limited data on QoL outcomes or even a standardisation for measuring QoL in this cohort as seen by the various validated tools used across studies. There continues to be a need for further work to understand the additional framework (psychological underpinning) to cause longer term impactful changes on both physical and psychological health in children with T1D. CI - (c) 2025. The Author(s). FAU - J Cockcroft, Emma AU - J Cockcroft E AUID- ORCID: 0000-0003-3798-9492 AD - University of Exeter Medical School, Exeter, EX1 2JP, UK. FAU - Chithuranjan, Dillon AU - Chithuranjan D AD - Institute of Applied Health Research, University of Birmingham, Birmingham, UK. FAU - Narendran, Parth AU - Narendran P AUID- ORCID: 0000-0002-4583-8793 AD - Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK. AD - Department of Diabetes, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK. FAU - C Andrews, Robert AU - C Andrews R AUID- ORCID: 0000-0003-4939-1738 AD - University of Exeter Medical School, Exeter, EX1 2JP, UK. AD - Department of Diabetes, Taunton and Somerset NHS Foundation Trust, Taunton, UK. FAU - P Dias, Renuka AU - P Dias R AUID- ORCID: 0000-0002-5743-1077 AD - University of Exeter Medical School, Exeter, EX1 2JP, UK. r.dias.1@bham.ac.uk. AD - Institute of Applied Health Research, University of Birmingham, Birmingham, UK. r.dias.1@bham.ac.uk. AD - Department of Paediatric Endocrinology and Diabetes, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK. r.dias.1@bham.ac.uk. AD - Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK. r.dias.1@bham.ac.uk. LA - eng PT - Journal Article PT - Systematic Review DEP - 20250501 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/therapy/psychology MH - *Quality of Life MH - *Exercise MH - Child MH - Adolescent PMC - PMC12044773 OTO - NOTNLM OT - Physical activity OT - Quality of life OT - Type 1 diabetes COIS- Declarations. Ethical approval: Not applicable. Consent for publication: Not applicable. Competing interests: RPD has received honoraria from Sanofi for participation in an advisory board on Teplizumab. EJC, DC, RCA and PN declare that they have no competing interest, financial or otherwise. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. Datasets: All data generated or analysed during this study are included in this published article. EDAT- 2025/05/02 00:27 MHDA- 2025/05/02 06:28 PMCR- 2025/05/01 CRDT- 2025/05/01 23:13 PHST- 2024/01/22 00:00 [received] PHST- 2025/03/25 00:00 [accepted] PHST- 2025/05/02 06:28 [medline] PHST- 2025/05/02 00:27 [pubmed] PHST- 2025/05/01 23:13 [entrez] PHST- 2025/05/01 00:00 [pmc-release] AID - 10.1186/s12887-025-05632-6 [pii] AID - 5632 [pii] AID - 10.1186/s12887-025-05632-6 [doi] PST - epublish SO - BMC Pediatr. 2025 May 1;25(1):345. doi: 10.1186/s12887-025-05632-6. PMID- 40312305 OWN - NLM STAT- MEDLINE DCOM- 20250502 LR - 20250504 IS - 1471-230X (Electronic) IS - 1471-230X (Linking) VI - 25 IP - 1 DP - 2025 May 1 TI - Modified triglyceride-glucose indices as novel predictors of metabolic dysfunction-associated fatty liver disease in US adolescents: a nationally representative study from NHANES 2017-2020. PG - 325 LID - 10.1186/s12876-025-03915-x [doi] LID - 325 AB - BACKGROUND: Metabolic dysfunction-associated fatty liver disease (MAFLD) has become the most prevalent chronic liver condition in adolescents. The triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, has shown promise in adult MAFLD detection but requires pediatric-specific validation, particularly when combined with anthropometric measures. This study investigated the association between modified TyG indices and MAFLD, and evaluated their predictive value in adolescents. METHODS: This cross-sectional study analyzed data from 532 adolescents (12-18 years) in the 2017-2020 National Health and Nutrition Examination Survey (NHANES) with complete records. MAFLD diagnosis was based on transient elastography plus metabolic criteria. The investigators employed multivariate linear regression and restricted cubic splines (RCS) to examine linear and nonlinear relationships between modified TyG indices and CAP values. Subgroup analyses were stratified by obesity status, and sensitivity analyses were performed on the NAFLD cohort (n = 527). Receiver operating characteristic (ROC) curve analysis, using Youden's index, evaluated the predictive performance of TyG indices for MAFLD identification. RESULTS: Among 130 MAFLD adolescents (vs 402 controls), modified TyG indices demonstrated significantly stronger associations with CAP in fully adjusted models compared to the original TyG index. TyG-WC showed the highest diagnostic accuracy (AUC = 0.923, 95%CI:0.900-0.947), followed by TyG-BMI (AUC = 0.917) and TyG-WHtR (AUC = 0.915), while the original TyG index performed poorly (AUC = 0.673). Subgroup analyses revealed particularly strong associations in non-obese participants, and sensitivity analyses confirmed result robustness after excluding potential confounders. Optimal cutoff values provided clinically useful screening thresholds, with TyG-WC achieving 94% sensitivity at 665.94. CONCLUSION: This study demonstrates that modified TyG indices incorporating anthropometric parameters (particularly TyG-WC) significantly outperform the original TyG index for MAFLD detection in adolescents, with superior diagnostic accuracy (AUC 0.915-0.923). The robust predictive performance maintained in sensitivity analyses and non-obese subgroups supports their clinical utility as simple, non-invasive screening tools for pediatric MAFLD risk stratification. CI - (c) 2025. The Author(s). FAU - Zou, Yigui AU - Zou Y AD - Key Laboratory for Precision Diagnosis and Treatment of Pediatric Digestive System Disease, Endoscopy Center, Shenzhen Children's Hospital, Shenzhen, Guangdong, 518036, China. FAU - Dai, Yu AU - Dai Y AD - Children's Healthcare and Mental Health Center, Shenzhen Children's Hospital, Shenzhen , Guangdong, 518036, China. FAU - Li, Ziyuan AU - Li Z AD - Key Laboratory for Precision Diagnosis and Treatment of Pediatric Digestive System Disease, Endoscopy Center, Shenzhen Children's Hospital, Shenzhen, Guangdong, 518036, China. FAU - Lin, Baixian AU - Lin B AD - Key Laboratory for Precision Diagnosis and Treatment of Pediatric Digestive System Disease, Endoscopy Center, Shenzhen Children's Hospital, Shenzhen, Guangdong, 518036, China. FAU - Chen, Hu AU - Chen H AD - Key Laboratory for Precision Diagnosis and Treatment of Pediatric Digestive System Disease, Endoscopy Center, Shenzhen Children's Hospital, Shenzhen, Guangdong, 518036, China. FAU - Zhuang, Zeling AU - Zhuang Z AD - Key Laboratory for Precision Diagnosis and Treatment of Pediatric Digestive System Disease, Endoscopy Center, Shenzhen Children's Hospital, Shenzhen, Guangdong, 518036, China. FAU - Li, Wenwen AU - Li W AD - Key Laboratory for Precision Diagnosis and Treatment of Pediatric Digestive System Disease, Endoscopy Center, Shenzhen Children's Hospital, Shenzhen, Guangdong, 518036, China. FAU - Yang, Qinghua AU - Yang Q AD - Key Laboratory for Precision Diagnosis and Treatment of Pediatric Digestive System Disease, Endoscopy Center, Shenzhen Children's Hospital, Shenzhen, Guangdong, 518036, China. FAU - Dai, Dongling AU - Dai D AD - Key Laboratory for Precision Diagnosis and Treatment of Pediatric Digestive System Disease, Endoscopy Center, Shenzhen Children's Hospital, Shenzhen, Guangdong, 518036, China. daidong3529@sina.com. LA - eng GR - JCYJ20220818102801004/Shenzhen Science and Technology Innovation Program/ GR - JCYJ20220818102801004/Shenzhen Science and Technology Innovation Program/ GR - JCYJ20220818102801004/Shenzhen Science and Technology Innovation Program/ GR - JCYJ20220818102801004/Shenzhen Science and Technology Innovation Program/ GR - LCYJ2022059/Guangdong High-level Hospital Construction Fund Clinical Research Project of Shenzhen Children's Hospital/ GR - LCYJ2022059/Guangdong High-level Hospital Construction Fund Clinical Research Project of Shenzhen Children's Hospital/ GR - LCYJ2022059/Guangdong High-level Hospital Construction Fund Clinical Research Project of Shenzhen Children's Hospital/ GR - LCYJ2022059/Guangdong High-level Hospital Construction Fund Clinical Research Project of Shenzhen Children's Hospital/ PT - Journal Article DEP - 20250501 PL - England TA - BMC Gastroenterol JT - BMC gastroenterology JID - 100968547 RN - 0 (Triglycerides) RN - 0 (Blood Glucose) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - Cross-Sectional Studies MH - *Triglycerides/blood MH - Child MH - Nutrition Surveys MH - United States/epidemiology MH - *Blood Glucose/analysis/metabolism MH - *Non-alcoholic Fatty Liver Disease/blood/diagnosis MH - Predictive Value of Tests MH - Biomarkers/blood MH - ROC Curve MH - Insulin Resistance MH - Elasticity Imaging Techniques PMC - PMC12044992 OTO - NOTNLM OT - Adolescent OT - Insulin resistance OT - Metabolic dysfunction-associated fatty liver disease OT - NHANES OT - TyG index COIS- Declarations. Ethics approval and consent to participate: The studies involving human participants were reviewed and approved by The National Center for Health Statistics (NCHS) Research Ethics Review Board. Written informed consent to participate in this study was provided by the participants' legal guardian/next of kin. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/05/02 00:27 MHDA- 2025/05/02 06:28 PMCR- 2025/05/01 CRDT- 2025/05/01 23:13 PHST- 2025/02/27 00:00 [received] PHST- 2025/04/18 00:00 [accepted] PHST- 2025/05/02 06:28 [medline] PHST- 2025/05/02 00:27 [pubmed] PHST- 2025/05/01 23:13 [entrez] PHST- 2025/05/01 00:00 [pmc-release] AID - 10.1186/s12876-025-03915-x [pii] AID - 3915 [pii] AID - 10.1186/s12876-025-03915-x [doi] PST - epublish SO - BMC Gastroenterol. 2025 May 1;25(1):325. doi: 10.1186/s12876-025-03915-x. PMID- 40312293 OWN - NLM STAT- MEDLINE DCOM- 20250502 LR - 20250514 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 May 1 TI - Diet quality, food security and traditional food intake of pregnant and breastfeeding women, and children 6 months to 5 years, living in eight remote Australian Aboriginal and Torres Strait Islander communities. PG - 1604 LID - 10.1186/s12889-025-22815-z [doi] LID - 1604 AB - BACKGROUND: Maternal and early childhood nutrition is foundational in setting the course for lifetime metabolic and disease outcomes. Food security influences the achievement of optimal diets; however, little is known about how traditional food intake may influence this dynamic for Aboriginal and Torres Strait Islander people living in remote communities. This study describes diets and food security status of Aboriginal and Torres Strait Islander pregnant and breastfeeding women and children 6 months to 5 years in remote communities in Australia, and explores interactions between diet quality, food security and traditional food consumption. METHODS: Baseline data from a trial testing a discount on healthy foods and drinks were used. Participants from eight communities (four each in coastal Cape York, Queensland and desert Central Australia, Northern Territory) participated in June-September 2021. A validated food frequency questionnaire was used to assess usual intake and calculate a diet quality score. A modified version of the United States Department of Agriculture 18-item Household Food Security Scale Module measured food security status. A model was fitted to explore the interactions between diet quality, food security and traditional food consumption. RESULTS: Complete dietary data were available for 471 participants from 294 households. Average reported food group intakes of children were similar to recommended patterns, however except for adequate meat intakes those of women were not; mean diet quality scores were 23% higher in children than women (p < 0.001). Long-duration breastfeeding was described (36% of > 2-4 years breastfed). High rates of household food insecurity were reported (76%), although rates were lower in Cape York (p < 0.001). Reported traditional food intake was higher in Cape York than in Central Australia (p < 0.001). For diet quality, a significant three-way interaction between food security status, traditional food frequency and adult/child status was demonstrated (p = 0.005). CONCLUSIONS: Remote community families carry out practices that protect and support the diet quality of children despite conditions that challenge food security and optimal diets. The role of traditional food consumption in reducing the impact of food insecurity on diet quality provides further evidence for Aboriginal and Torres Strait Islander food systems to be at the centre of comprehensive efforts to address food insecurity. TRIAL REGISTRATION: This work is part of a trial that has been registered with Australian New Zealand Clinical Trials Registry: ACTRN12621000640808. Trial registration date: 28/05/2021. CI - (c) 2025. The Author(s). FAU - Tonkin, Emma AU - Tonkin E AD - Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, VIC, 3168, Australia. emma.tonkin@monash.edu. AD - School of Public Health, The University of Queensland, Herston, QLD, 4006, Australia. emma.tonkin@monash.edu. FAU - Chatfield, Mark D AU - Chatfield MD AD - School of Public Health, The University of Queensland, Herston, QLD, 4006, Australia. FAU - Brimblecombe, Julie AU - Brimblecombe J AD - Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, VIC, 3168, Australia. AD - School of Public Health, Menzies School of Health Research, Northern Territory, Casuarina, 0810, Australia. FAU - Kleve, Sue AU - Kleve S AD - Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, VIC, 3168, Australia. FAU - Chan, Ellie AU - Chan E AD - School of Public Health, The University of Queensland, Herston, QLD, 4006, Australia. AD - Central Australian Aboriginal Congress, Northern Territory, Alice Springs, 0870, Australia. FAU - Deen, Caroline AU - Deen C AD - Apunipima Cape York Health Council, Bungalow, QLD, 4870, Australia. FAU - Brown, Clare AU - Brown C AD - Apunipima Cape York Health Council, Bungalow, QLD, 4870, Australia. FAU - Stubbs, Emma AU - Stubbs E AD - Central Australian Aboriginal Congress, Northern Territory, Alice Springs, 0870, Australia. FAU - Booth, Sue AU - Booth S AD - College of Medicine and Public Health, Flinders University, Adelaide, South Australia, 5000, Australia. AD - School of Population Health, Curtin University, Bentley, WA, 6012, Australia. FAU - Thompson, Kani AU - Thompson K AD - Apunipima Cape York Health Council, Bungalow, QLD, 4870, Australia. FAU - Pauli, Jenna AU - Pauli J AD - Central Australian Aboriginal Congress, Northern Territory, Alice Springs, 0870, Australia. FAU - Leonard, Dympna AU - Leonard D AD - Apunipima Cape York Health Council, Bungalow, QLD, 4870, Australia. AD - Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, 4870, Australia. FAU - Lee, Amanda AU - Lee A AD - School of Public Health, The University of Queensland, Herston, QLD, 4006, Australia. FAU - Fredericks, Bronwyn AU - Fredericks B AD - Office of the Deputy-Vice-Chancellor, The University of Queensland, Herston, QLD, 4006, Australia. FAU - Ferguson, Megan AU - Ferguson M AD - School of Public Health, The University of Queensland, Herston, QLD, 4006, Australia. AD - Menzies School of Health Research, Northern Territory, Casuarina, 0810, Australia. LA - eng GR - 1179848/National Health and Medical Research Council/ GR - 1179848/National Health and Medical Research Council/ GR - 1179848/National Health and Medical Research Council/ GR - 1179848/National Health and Medical Research Council/ GR - 1179848/National Health and Medical Research Council/ GR - 1179848/National Health and Medical Research Council/ GR - 1179848/National Health and Medical Research Council/ GR - 1179848/National Health and Medical Research Council/ GR - 1179848/National Health and Medical Research Council/ GR - 1179848/National Health and Medical Research Council/ GR - 1179848/National Health and Medical Research Council/ GR - 1179848/National Health and Medical Research Council/ GR - 1179848/National Health and Medical Research Council/ GR - 1179848/National Health and Medical Research Council/ GR - 1179848/National Health and Medical Research Council/ PT - Journal Article DEP - 20250501 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Adult MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Pregnancy MH - Australia MH - *Australian Aboriginal and Torres Strait Islander Peoples/statistics & numerical data MH - *Breast Feeding/statistics & numerical data/ethnology MH - *Diet/statistics & numerical data MH - *Food Security/statistics & numerical data MH - Rural Population/statistics & numerical data PMC - PMC12045012 OTO - NOTNLM OT - Australia OT - Diet OT - First Nations OT - Food OT - Food security OT - Indigenous OT - Public health COIS- Declarations. Ethics approval and consent to participate: Approval for the research was granted by the Research Governance Committee of Apunipima Cape York Health Council and Central Australian Aboriginal Congress Board. Ethics approval was granted from the University of Queensland (2020/HE000636) and the Central Australian Human Research Ethics Committees (CA-203701). The broader Remote Food Security study from which these data are drawn was conducted in accordance with these guidelines and regulations, and according to the guidelines in the Declaration of Helsinki. All participants provided informed consent to participate. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/05/02 00:28 MHDA- 2025/05/02 06:28 PMCR- 2025/05/01 CRDT- 2025/05/01 23:13 PHST- 2024/12/06 00:00 [received] PHST- 2025/04/15 00:00 [accepted] PHST- 2025/05/02 06:28 [medline] PHST- 2025/05/02 00:28 [pubmed] PHST- 2025/05/01 23:13 [entrez] PHST- 2025/05/01 00:00 [pmc-release] AID - 10.1186/s12889-025-22815-z [pii] AID - 22815 [pii] AID - 10.1186/s12889-025-22815-z [doi] PST - epublish SO - BMC Public Health. 2025 May 1;25(1):1604. doi: 10.1186/s12889-025-22815-z. PMID- 40991759 STAT- Publisher PB - Agency for Healthcare Research and Quality (US) CTI - AHRQ EPC Systematic Reviews DP - 2025 May BTI - Digestible Carbohydrate Intake and Maternal-Infant Outcomes: A Systematic Review AB - BACKGROUND. Optimal nutrition is needed to support individuals during pregnancy and placental development, fetal growth, and growth and development during infancy. Many foods contain digestible carbohydrates, or carbohydrates other than fiber/nondigestible carbohydrate. Digestible carbohydrates, including sugars and starches, are important sources of energy during these life stages. This review was designed to identify and summarize the evidence on the relationships between digestible carbohydrate intake during pregnancy and newborn size and development (Key Question 1) and gestational weight gain (Key Question 2), and between infant digestible carbohydrate intake and infant growth parameters, size, and body composition from birth to 24 months of age (Key Question 3). The results are intended to contribute to the update and expansion of the 2005 United States and Canadian Dietary Reference Intakes (DRIs) for macronutrients. METHODS. A medical research librarian designed and conducted a search of Ovid MEDLINE((R)), Embase((R)), and Cochrane CENTRAL from 2000 to April 2025. Researchers manually reviewed reference lists. Using a priori specified inclusion and exclusion criteria, we triaged abstracts and conducted a dual, independent review of full-text articles. Risk of bias was assessed using criteria based on study design. Meta-analyses were not conducted due to limited data and heterogeneity of studies; included studies were synthesized qualitatively and described in tables and text. RESULTS. Searches identified 3,194 abstracts. Eight studies in 10 publications were included for the three Key Questions. One randomized controlled trial was rated low risk of bias and a second was rated high; three nonrandomized studies were rated moderate and three were rated high risk of bias. Identified studies yielded low strength of evidence of no difference in infant weight, and insufficient evidence for length, head circumference, or size (small or large for gestational age) at birth (Key Question 1) and low strength of evidence of no difference in gestational weight gain given different amounts of digestible carbohydrate intake during pregnancy (Key Question 2). Evidence was insufficient to reach conclusions about the relationship between digestible carbohydrate intake by infants and growth outcomes (weight, length, and head circumference) and body mass index or other body composition outcomes up to 24 months of age (Key Question 3). CONCLUSIONS. We identified a small number of studies resulting in findings of no differences in infant size at birth and gestational weight gain by amount of digestible carbohydrate consumed during pregnancy. There was insufficient evidence to draw a conclusion about the relationship between the amount of digestible carbohydrate consumed during infancy and growth parameters and body composition up to 24 months of age. Factors contributing to the limited evidence available to answer the Key Questions in this review include the following: "Digestible carbohydrate" is not commonly used in the scientific literature to categorize dietary carbohydrates as the alternative to fiber/nondigestible carbohydrate; most studies identified, those included in or excluded from the evidence base, were not designed to answer this review's Key Questions; and there is an increasing trend toward reporting dietary consumption patterns instead of isolated nutrients and using principal component analysis to categorize and analyze dietary consumption patterns. While both types of information are important to informing how diet affects health, analyses of patterns do not provide the specific quantitative information needed for a systematic review of the effect of digestible carbohydrate consumption on maternal and infant outcomes. The limited evidence, and our concerns about the lack of methodologic standardization and the validity of dietary intake measurement used to estimate usual dietary intake during pregnancy and lactation and of infants consuming human milk, reduced our confidence in the findings and support the need for additional and more rigorous research on this topic. FAU - Stadler, Diane D AU - Stadler DD FAU - Jungbauer, Rebecca M AU - Jungbauer RM FAU - Ahmed, Azrah Y AU - Ahmed AY FAU - Marshall, Nicole E AU - Marshall NE FAU - Valent, Amy M AU - Valent AM FAU - Totten, Annette M AU - Totten AM LA - eng PT - Review PT - Book PL - Rockville (MD) EDAT- 2025/05/01 00:00 CRDT- 2025/05/01 00:00 AID - NBK618350 [bookaccession] AID - 10.23970/AHRQEPCSRCARBMATERNAL [doi] PMID- 40306385 OWN - NLM STAT- MEDLINE DCOM- 20250703 LR - 20260714 IS - 1938-3207 (Electronic) IS - 0002-9165 (Linking) VI - 122 IP - 1 DP - 2025 Jul TI - Comparison of methods for estimating discretionary salt intake among females of reproductive age in Oromia region, Ethiopia. PG - 157-165 LID - S0002-9165(25)00246-1 [pii] LID - 10.1016/j.ajcnut.2025.04.029 [doi] AB - BACKGROUND: Accurate and precise estimates of discretionary salt intake are essential to the design of salt fortification and sodium reduction interventions; however, there is limited methodological guidance for low-resource field settings. OBJECTIVES: The objective of this study was to compare measures of association and agreement between the weighed food record (WFR) and 4 other methods for estimating daily discretionary salt intake among females of reproductive age (FRA) in the Oromia region of Ethiopia. METHODS: A total of 100 FRA were enrolled in a cross-sectional study that assessed discretionary salt intake using 5 approaches: 1) 1-d WFRs; 2) duplicate diet composites to assess the total sodium content of the diet and preparation of corresponding replicate diet composites excluding discretionary salt to measure the intrinsic sodium content of the diet in 40 participants; 3) 24-h urinary sodium excretion; 4) 1-d household salt disappearance; and 5) 1-wk household salt disappearance. WFR, 1-d household salt disappearance, and 24-h urine collections were repeated in a subset of 40 participants to estimate usual discretionary salt intake from observed discretionary salt intake. Correlation and Bland-Altman analyses were conducted to assess the association and agreement between the WFR and methods 2-5. RESULTS: Estimates of the mean +/- SD discretionary salt intake ranged from 6.8 +/- 1.9 g/d (WFR usual intake estimate) to 10.0 +/- 7.3 g/d (1-d household salt disappearance per household member). One-day salt disappearance per adult female equivalent and per household member was most strongly associated with the WFR method (r = 0.675, P < 0.001 and r = 0.645, P < 0.001, respectively). The difference in mean discretionary salt intake was the smallest between the replicate diet composite and the WFR method (-0.58 +/- 4.21 g). CONCLUSIONS: The WFR method, our predefined reference method, with repeated assessments in a subgroup of participants likely yields the most precise and accurate estimation of actual discretionary salt intake. If resource constraints preclude this method, estimating salt utilization per household member via a 1-d disappearance study following preliminary WFRs to allow for potential adjustment may be an appropriate alternative. CI - Copyright (c) 2025 The Authors. Published by Elsevier Inc. All rights reserved. FAU - McDonald, Christine M AU - McDonald CM AD - Department of Pediatrics, University of California San Francisco, Oakland, CA, United States; Department of Nutrition and Institute for Global Nutrition, University of California, Davis, CA, United States. Electronic address: christine.mcdonald@ucsf.edu. FAU - Agbemafle, Isaac AU - Agbemafle I AD - Department of Nutrition and Institute for Global Nutrition, University of California, Davis, CA, United States; Department of Nutrition, University of Rhode Island, Kingston, RI, United States; Fred N. Binka School of Public Health, University of Health, and Allied Sciences, Ho, Ghana. FAU - Woldeyohannes, Meseret AU - Woldeyohannes M AD - Food Science and Nutrition Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia. FAU - Tessema, Masresha AU - Tessema M AD - Food Science and Nutrition Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia. FAU - Fereja, Mengistu AU - Fereja M AD - Food Science and Nutrition Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia. FAU - Assefa, Teshome AU - Assefa T AD - Food Science and Nutrition Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia. FAU - Arnold, Charles D AU - Arnold CD AD - Department of Nutrition and Institute for Global Nutrition, University of California, Davis, CA, United States. FAU - Tesfaye, Biniyam AU - Tesfaye B AD - Department of Nutrition and Institute for Global Nutrition, University of California, Davis, CA, United States; Food Science and Nutrition Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia. FAU - Goh, Yvonne E AU - Goh YE AD - Department of Pediatrics, University of California San Francisco, Oakland, CA, United States. FAU - Arabi, Mandana AU - Arabi M AD - Research & Development Unit, Nutrition International, Ottawa, Canada. FAU - Martinez, Homero AU - Martinez H AD - Research & Development Unit, Nutrition International, Ottawa, Canada. FAU - Brown, Kenneth H AU - Brown KH AD - Department of Nutrition and Institute for Global Nutrition, University of California, Davis, CA, United States. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250428 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 RN - 0 (Sodium Chloride, Dietary) RN - 9NEZ333N27 (Sodium) SB - IM MH - Humans MH - Female MH - Ethiopia MH - Adult MH - *Sodium Chloride, Dietary/administration & dosage MH - Cross-Sectional Studies MH - Young Adult MH - Diet Records MH - Adolescent MH - *Diet MH - Middle Aged MH - Sodium/urine OTO - NOTNLM OT - dietary assessment OT - ethiopia OT - large-scale food fortification OT - salt fortification OT - salt intake COIS- Conflict of interest KHB, CMM, IA, BT, MF, MW, and MT report financial support was provided by Nutrition International. HM and MA are employees of Nutrition International, which provided funding to the University of CaliforniaDavis for this research. HM and MA provided technical inputs to the study but did not influence the design or interpretation of the study results. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/05/01 00:26 MHDA- 2025/07/04 00:27 CRDT- 2025/04/30 19:31 PHST- 2024/11/08 00:00 [received] PHST- 2025/04/15 00:00 [revised] PHST- 2025/04/24 00:00 [accepted] PHST- 2025/07/04 00:27 [medline] PHST- 2025/05/01 00:26 [pubmed] PHST- 2025/04/30 19:31 [entrez] AID - S0002-9165(25)00246-1 [pii] AID - 10.1016/j.ajcnut.2025.04.029 [doi] PST - ppublish SO - Am J Clin Nutr. 2025 Jul;122(1):157-165. doi: 10.1016/j.ajcnut.2025.04.029. Epub 2025 Apr 28. PMID- 40303556 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20261028 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 13 DP - 2025 TI - Validation of the BioIntelliSense BioButton(R) device for physical activity monitoring in children and future application as a physical health outcome for critically Ill children. PG - 1544404 LID - 10.3389/fped.2025.1544404 [doi] LID - 1544404 AB - INTRODUCTION: Mobile monitoring devices offer an opportunity to characterize physical health recovery in children who survive critical illness. METHODS: To validate the BioIntelliSense BioButton(R) as a pediatric activity monitor, we studied healthy children (2-17 years-old) who wore the BioButton(R) device and an ActiGraph wGT3X-BT accelerometer, and a study team member documented activity in 1 min intervals (gold standard) during 45 min of scripted activities. In two-thirds of the cohort (derivation cohort), we identified BioButton activity count thresholds to differentiate activity levels based on highest Youden indices. Thresholds were applied to the remainder of the cohort (validation cohort) to determine sensitivity and specificity [95% confidence interval (CI)]. We also evaluated BioButton activity designations compared with accelerometer designations and calculated agreement between BioButton-measured body position and the activity log. RESULTS: Forty-five participants provided a median 43 (IQR 41, 44) analyzable minutes. Sensitivity and specificity of derived BioButton thresholds were 0.78 (95% CI: 0.69, 0.88) and 0.95 (95% CI: 0.90, 0.97) to identify moderate or vigorous activity (MVPA) and 0.91 (95% CI: 0.87, 0.95) and 0.98 (95% CI: 0.98, 0.98) to identify sedentary behavior. Sensitivity and specificity compared with the accelerometer were 0.52 (95% CI: 0.45-0.60) and 0.88 (95% CI: (95% CI: 0.84, 0.93) to identify MVPA and 0.92 (95% CI: 0.89-0.96) and 0.70 (95% CI: 0.67, 0.73) to identify sedentary behavior. The BioButton accurately identified position during 1,125 of 1,432 (78.6%) minutes. DISCUSSION: The BioButton device accurately identified physical activity and body position in children and may be a useful tool to quantify physical activity as an outcome in future trials. CI - (c) 2025 Petruccelli, Miller, Greer, Sauceda, Watson, Mourani and Maddux. FAU - Petruccelli, Lexi AU - Petruccelli L AD - Research Institute, Pediatric Critical Care, Children's Hospital Colorado, Aurora, CO, United States. FAU - Miller, Kristen R AU - Miller KR AD - Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, United States. FAU - Greer, Rachel AU - Greer R AD - Research Institute, Pediatric Critical Care, Children's Hospital Colorado, Aurora, CO, United States. FAU - Sauceda, Heidi AU - Sauceda H AD - Research Institute, Pediatric Critical Care, Children's Hospital Colorado, Aurora, CO, United States. FAU - Watson, R Scott AU - Watson RS AD - Department of Pediatrics, Division of Critical Care, University of Washington, Seattle, WA, United States. AD - Seattle Children's Research Institute, Seattle Children's Hospital, Seattle, WA, United States. FAU - Mourani, Peter M AU - Mourani PM AD - Department of Pediatrics, Section of Critical Care, University of Arkansas for Medical Sciences and Arkansas Children's, Little Rock, AR, United States. FAU - Maddux, Aline B AU - Maddux AB AD - Department of Pediatrics, Section of Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO, United States. AD - Children's Hospital Colorado, Aurora, CO, United States. LA - eng GR - K23 HD096018/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20250415 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC12037551 OTO - NOTNLM OT - critical care outcomes OT - exercise OT - patient outcome assessment (MeSH) OT - pediatrics-children OT - sedentary behavior COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/04/30 11:07 MHDA- 2025/04/30 11:08 PMCR- 2025/04/15 CRDT- 2025/04/30 05:01 PHST- 2024/12/12 00:00 [received] PHST- 2025/03/13 00:00 [accepted] PHST- 2025/04/30 11:08 [medline] PHST- 2025/04/30 11:07 [pubmed] PHST- 2025/04/30 05:01 [entrez] PHST- 2025/04/15 00:00 [pmc-release] AID - 10.3389/fped.2025.1544404 [doi] PST - epublish SO - Front Pediatr. 2025 Apr 15;13:1544404. doi: 10.3389/fped.2025.1544404. eCollection 2025. PMID- 40299092 OWN - NLM STAT- MEDLINE DCOM- 20250429 LR - 20250502 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 30 IP - 1 DP - 2025 Apr 29 TI - Beyond healthy eating: introducing ONI-Hu, the Hungarian version of the Orthorexia Nervosa Inventory. PG - 38 LID - 10.1007/s40519-025-01745-0 [doi] LID - 38 AB - PURPOSE: The aim of this study was to adapt the Orthorexia Nervosa Inventory for use in Hungarian (ONI-Hu), and explore its associations with disordered eating, intuitive eating and mental health measures. METHODS: 944 participants completed a test battery, including ONI-Hu, the Three Factor Eating Questionnaire, the Intuitive Eating Scale-2 and the Mental Health Continuum Short-Form. Confirmatory Factor Analysis (CFA) was used to assess the validity of ONI-Hu. Correlation and regression analyses were conducted to evaluate the convergent and discriminant validity. RESULTS: CFA confirmed the original three-factor structure of ONI-Hu. Positive associations were found between ONI scores and restrictive eating behaviors, and negative associations with intuitive eating measures. Furthermore, the ONI composite factor score displayed no significant relationship with mental health indicators. CONCLUSIONS: ONI-Hu exhibits strong reliability and validity, and provides a deeper understanding of ON. Results suggest that orthorexic behaviors may serve as a coping mechanism, offering an illusion of control and emotional security. Inconsistent findings about the relationship between ON tendencies and mental health indicators propose that the sense of control might provide a false sense of well-being to the individual, distorting their perceptions of their overall health. Level of evidence Level V, descriptive cross-sectional study. CI - (c) 2025. The Author(s). FAU - Fodor, Alexandra AU - Fodor A AUID- ORCID: 0009-0000-2898-3844 AD - Doctoral School of Psychology, ELTE Eotvos Lorand University, Budapest, Hungary. fodor.alexandra@ppk.elte.hu. AD - Institute of Psychology, ELTE Eotvos Lorand University, Budapest, Hungary. fodor.alexandra@ppk.elte.hu. FAU - Varga, Balazs Andras AU - Varga BA AUID- ORCID: 0000-0002-7097-907X AD - Doctoral School of Psychology, ELTE Eotvos Lorand University, Budapest, Hungary. AD - Institute of Psychology, ELTE Eotvos Lorand University, Budapest, Hungary. FAU - Rigo, Adrien AU - Rigo A AUID- ORCID: 0000-0003-2940-2110 AD - Institute of Psychology, ELTE Eotvos Lorand University, Budapest, Hungary. LA - eng PT - Journal Article DEP - 20250429 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - Female MH - Adult MH - Hungary MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Reproducibility of Results MH - *Feeding Behavior/psychology MH - Young Adult MH - Surveys and Questionnaires MH - Male MH - Cross-Sectional Studies MH - Middle Aged MH - Adolescent MH - Psychometrics MH - Factor Analysis, Statistical MH - Mental Health MH - *Diet, Healthy/psychology PMC - PMC12041154 OTO - NOTNLM OT - Disordered eating OT - Orthorexia nervosa OT - Reliability COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/04/29 12:40 MHDA- 2025/04/29 12:41 PMCR- 2025/04/29 CRDT- 2025/04/29 11:19 PHST- 2023/11/07 00:00 [received] PHST- 2025/03/24 00:00 [accepted] PHST- 2025/04/29 12:41 [medline] PHST- 2025/04/29 12:40 [pubmed] PHST- 2025/04/29 11:19 [entrez] PHST- 2025/04/29 00:00 [pmc-release] AID - 10.1007/s40519-025-01745-0 [pii] AID - 1745 [pii] AID - 10.1007/s40519-025-01745-0 [doi] PST - epublish SO - Eat Weight Disord. 2025 Apr 29;30(1):38. doi: 10.1007/s40519-025-01745-0. PMID- 40299004 OWN - NLM STAT- MEDLINE DCOM- 20250808 LR - 20260715 IS - 1432-0711 (Electronic) IS - 0932-0067 (Print) IS - 0932-0067 (Linking) VI - 312 IP - 2 DP - 2025 Aug TI - The performance of sonographic antenatal birth weight assessment assisted with artificial intelligence compared to that of manual examiners at term. PG - 487-493 LID - 10.1007/s00404-025-08042-2 [doi] AB - PURPOSE: The aim of this study is to investigate the differences in the accuracy of sonographic antenatal fetal weight estimation at term with artificial intelligence (AI) compared to that of clinical sonographers at different levels of experience. METHODS: This is a prospective cohort study where pregnant women at term scheduled for an imminent elective cesarean section were recruited. Three independent antenatal fetal weight estimations for each fetus were blindly measured by an experienced resident physician with level I qualification from the German Society for Ultrasound in Medicine (group 1), a senior physician with level II qualification (group 2), and an AI-supported algorithm (group 3) using Hadlock formula 3. The differences between the three groups and the actual birth weight were examined with a paired t-test. A variation within 10% of birth weight was deemed accurate, and the diagnostic accuracies of both groups 1 and 3 compared to group 2 were assessed using receiver operating characteristic (ROC) curves. The association between accuracy and potential influencing factors including gestational age, fetal position, maternal age, maternal body mass index (BMI), twins, neonatal gender, placental position, gestational diabetes, and amniotic fluid index was tested with univariate logistic regression. A sensitivity analysis by inflating the estimated weights by daily 25 grams (g) gain for days between examination and birth was conducted. RESULTS: 300 fetuses at a mean gestational week of 38.7 +/- 1.1 were included in this study and examined on median 2 (2-4) days prior to delivery. Average birth weight was 3264.6 +/- 530.7 g and the mean difference of the sonographic estimated fetal weight compared to birthweight was -203.6 +/- 325.4 g, -132.2 +/- 294.1 g, and -338.4 +/- 606.2 g for groups 1, 2, and 3 respectively. The estimated weight was accurate in 62% (56.2%, 67.5%), 70% (64.5%, 75,1%), and 48.3% (42.6%, 54.1%) for groups 1, 2, and 3 respectively. The diagnostic accuracy measures for groups 1 and 3 compared to group 2 resulted in 55.7% (48.7%, 62.5%) and 68.6% (61.8%, 74.8%) sensitivity, 68.9% (58.3%, 78.2%) and 53.3% (42.5%, 63.9%) specificity and 0.62 (0.56, 0.68) and 0.61 (0.55, 0.67) area under the ROC curves respectively. There was no association between accuracy and the investigated variables. Adjusting for sensitivity analysis increased the accuracy to 68% (62.4%, 73.2%), 75% (69.7%, 79.8%), and 51.3% (45.5%, 57.1%), and changed the mean difference compared to birth weight to -136.1 +/- 321.8 g, -64.7 +/- 291.2 g, and -270.7 +/- 605.2 g for groups 1, 2, and 3 respectively. CONCLUSION: The antenatal weight estimation by experienced specialists with high-level qualifications remains the gold standard and provides the highest precision. Nevertheless, the accuracy of this standard is less than 80% even after adjusting for daily weight gain. The tested AI-supported method exhibits high variability and requires optimization and validation before being reliably used in clinical practice. CI - (c) 2025. The Author(s). FAU - Horky, Alex AU - Horky A AD - Department of Obstetrics and Gynecology, Buergerhospital - Dr. Senckenberg Foundation, Nibelungenallee 37-41, 60318, Frankfurt, Hessen, Germany. FAU - Wasenitz, Marita AU - Wasenitz M AD - Department of Obstetrics and Gynecology, Buergerhospital - Dr. Senckenberg Foundation, Nibelungenallee 37-41, 60318, Frankfurt, Hessen, Germany. FAU - Iacovella, Carlotta AU - Iacovella C AD - Department of Obstetrics and Gynecology, Buergerhospital - Dr. Senckenberg Foundation, Nibelungenallee 37-41, 60318, Frankfurt, Hessen, Germany. FAU - Bahlmann, Franz AU - Bahlmann F AD - Department of Obstetrics and Gynecology, Buergerhospital - Dr. Senckenberg Foundation, Nibelungenallee 37-41, 60318, Frankfurt, Hessen, Germany. FAU - Al Naimi, Ammar AU - Al Naimi A AUID- ORCID: 0000-0001-5345-4688 AD - Department of Obstetrics and Gynecology, Buergerhospital - Dr. Senckenberg Foundation, Nibelungenallee 37-41, 60318, Frankfurt, Hessen, Germany. ammar.alnaimi@uclmail.net. AD - Department of Obstetrics and Prenatal Medicine, Goethe University, University Hospital of Frankfurt, Hessen, Germany. ammar.alnaimi@uclmail.net. LA - eng PT - Comparative Study PT - Journal Article DEP - 20250429 PL - Germany TA - Arch Gynecol Obstet JT - Archives of gynecology and obstetrics JID - 8710213 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Artificial Intelligence MH - *Ultrasonography, Prenatal/methods MH - Prospective Studies MH - Adult MH - *Birth Weight MH - *Fetal Weight MH - Infant, Newborn MH - Gestational Age MH - ROC Curve MH - Clinical Competence MH - Sensitivity and Specificity MH - Algorithms PMC - PMC12334502 OTO - NOTNLM OT - Artificial intelligence OT - Fetal weight assessment OT - Sonographer's experience OT - Sonography COIS- Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: The study has been approved by the Ethics Committee at the Hesse State Chamber of Physicians (2023-3526-evBO). Consent to participate: Written consent is within the inclusion criteria. Consent for publication: Included in the participation consent. EDAT- 2025/04/29 12:40 MHDA- 2025/08/09 13:46 PMCR- 2025/04/29 CRDT- 2025/04/29 11:15 PHST- 2025/03/10 00:00 [received] PHST- 2025/04/22 00:00 [accepted] PHST- 2025/08/09 13:46 [medline] PHST- 2025/04/29 12:40 [pubmed] PHST- 2025/04/29 11:15 [entrez] PHST- 2025/04/29 00:00 [pmc-release] AID - 10.1007/s00404-025-08042-2 [pii] AID - 8042 [pii] AID - 10.1007/s00404-025-08042-2 [doi] PST - ppublish SO - Arch Gynecol Obstet. 2025 Aug;312(2):487-493. doi: 10.1007/s00404-025-08042-2. Epub 2025 Apr 29. PMID- 40298713 OWN - NLM STAT- MEDLINE DCOM- 20250429 LR - 20250429 IS - 1678-4561 (Electronic) IS - 1413-8123 (Linking) VI - 30 IP - 4 DP - 2025 Apr TI - The food retail environment around schools in a low-income Brazilian city: a street audit evaluation. PG - e08472023 LID - S1413-81232025000400902 [pii] LID - 10.1590/1413-81232025304.08472023 [doi] AB - This cross-sectional study evaluated the retail food environment (FE) around early childhood education centers (ECEC) in Rio Largo/AL, Brazil. Food retail outlets (FRO) were identified through a city street survey and audited using the Brazilian version of the Nutrition Environment Measurement Survey for Stores (NEMS-S). The Department of Education provided the ECEC's addresses, which were validated and geocoded (n=21). Schools' surroundings were defined by 400- and 800-meter buffers. The FE was analyzed using the healthy food availability index (HFAI), average distance between FRO and ECEC, and distribution and density of FRO according to the predominant type of food marketed (healthy, mixed, and unhealthy). Respectively, 332 (57.7%) and 505 (87.8%) FRO were identified in the 400- and 800-meter buffers. On average, 23 (400 m) and 54 (800 m) FRO were around schools, where ~60% were unhealthy (clustered throughout the city). The HFAI was very low for both buffers (400m: -1 points [IQR -6; 10]; 800m: -2 points [IQR -6; 10]). In conclusion, the city does not offer a supportive community food environment for children to develop and maintain healthy eating patterns. FAU - Costa, Gabriel M A AU - Costa GMA AUID- ORCID: 0000-0003-4806-6431 AD - Programa de Pos-Graduacao em Nutricao, Universidade Federal de Alagoas. Maceio AL Brasil. FAU - Vidal, Nicole A C AU - Vidal NAC AUID- ORCID: 0000-0003-3897-9202 AD - Programa de Pos-Graduacao em Nutricao, Universidade Federal de Alagoas. Maceio AL Brasil. FAU - Almeida, Nykholle B AU - Almeida NB AUID- ORCID: 0000-0002-8536-3972 AD - Programa de Pos-Graduacao em Nutricao, Universidade Federal de Alagoas. Maceio AL Brasil. FAU - Aragao, Luan S AU - Aragao LS AUID- ORCID: 0009-0001-3855-4071 AD - Programa de Pos-Graduacao em Nutricao, Universidade Federal de Alagoas. Maceio AL Brasil. FAU - Menezes, Risia C E AU - Menezes RCE AUID- ORCID: 0000-0003-1568-2836 AD - Programa de Pos-Graduacao em Nutricao, Universidade Federal de Alagoas. Maceio AL Brasil. FAU - Longo-Silva, Giovana AU - Longo-Silva G AUID- ORCID: 0000-0003-0776-0638 AD - Programa de Pos-Graduacao em Nutricao, Universidade Federal de Alagoas. Maceio AL Brasil. FAU - Silveira, Jonas A C AU - Silveira JAC AUID- ORCID: 0000-0003-3838-6212 AD - Departamento de Nutricao, Universidade Federal do Parana. Av. Prefeito Lothario Meissner 632, Jardim Botanico. 80210-170 Curitiba PR Brasil. jonas.silveira@ufpr.br. LA - eng PT - Journal Article DEP - 20240223 PL - Brazil TA - Cien Saude Colet JT - Ciencia & saude coletiva JID - 9713483 SB - IM MH - Brazil MH - *Schools MH - Cross-Sectional Studies MH - Humans MH - *Food Supply/statistics & numerical data MH - Poverty MH - *Commerce/statistics & numerical data MH - Cities MH - Child EDAT- 2025/04/29 12:40 MHDA- 2025/04/29 12:41 CRDT- 2025/04/29 10:15 PHST- 2023/03/31 00:00 [received] PHST- 2024/02/21 00:00 [accepted] PHST- 2025/04/29 12:41 [medline] PHST- 2025/04/29 12:40 [pubmed] PHST- 2025/04/29 10:15 [entrez] AID - S1413-81232025000400902 [pii] AID - 10.1590/1413-81232025304.08472023 [doi] PST - ppublish SO - Cien Saude Colet. 2025 Apr;30(4):e08472023. doi: 10.1590/1413-81232025304.08472023. Epub 2024 Feb 23. PMID- 40298009 OWN - NLM STAT- MEDLINE DCOM- 20250429 LR - 20260924 IS - 1735-3947 (Electronic) IS - 1029-2977 (Print) IS - 1029-2977 (Linking) VI - 28 IP - 3 DP - 2025 Mar 1 TI - Weight Management Processes and Individual Differences: A Validation Study of P-Weight and S-Weight in Farsi. PG - 162-170 LID - 10.34172/aim.33513 [doi] AB - BACKGROUND: The obesity epidemic is a growing public health concern, making weight management a crucial aspect of overall health and well-being. Indeed, effective tools to facilitate behavior change are essential for achieving long-term success in managing weight. This study aimed to validate the Farsi versions of the S-weight and P-weight questionnaires to support personalized weight management by assessing specific aspects of psychological readiness, including motivation, self-regulation, emotional reappraisal (EmR), and environmental restructuring (EnR). METHODS: A cross-sectional study using self-administered questionnaires was conducted. The study included 455 adults aged 17-65, excluding those undergoing invasive weight-loss interventions. The measured variables included EmR, weight consequence evaluation (WCE), weight management actions (WMA), and EnR, which were assessed using structured Likert-scale questionnaires. Exploratory and confirmatory factor analyses were performed, with reliability evaluated via Cronbach's alpha and intraclass correlation coefficient (ICC). Statistical significance was set at P<0.05. RESULTS: The questionnaires showed strong validity and reliability (KMO=0.91; Bartlett's test chi(2)=3999.75; P<0.001). Overweight and obese participants scored significantly higher in change processes than normal-weight participants (P<0.001). CONCLUSION: The validated instruments provide a reliable means of tailoring weight management strategies based on psychological readiness, potentially improving long-term outcomes. CI - (c) 2025 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. FAU - Gohari Dezfuli, Zahra AU - Gohari Dezfuli Z AUID- ORCID: 0000-0001-5813-6283 AD - Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. FAU - Hasan Rashedi, Minoo AU - Hasan Rashedi M AUID- ORCID: 0000-0002-0571-0605 AD - Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. AD - Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. FAU - Araminejad, Mina AU - Araminejad M AUID- ORCID: 0009-0000-2560-786X AD - Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. FAU - Karimi, Keyvan AU - Karimi K AUID- ORCID: 0000-0001-7848-4410 AD - Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. AD - Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. FAU - Mansouri, Ensieh Sadat AU - Mansouri ES AD - Department of Internal Medicine, School of Medicine, Sina Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran. FAU - Seif Barghi, Tohid AU - Seif Barghi T AUID- ORCID: 0000-0001-7791-2372 AD - Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. FAU - Memari, Amir-Hossein AU - Memari AH AUID- ORCID: 0000-0002-8302-1821 AD - Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. LA - eng PT - Journal Article PT - Validation Study DEP - 20250301 PL - Iran TA - Arch Iran Med JT - Archives of Iranian medicine JID - 100889644 SB - IM MH - Humans MH - Adult MH - Female MH - Male MH - Cross-Sectional Studies MH - Middle Aged MH - Surveys and Questionnaires/standards MH - Adolescent MH - Reproducibility of Results MH - Young Adult MH - *Obesity/psychology/therapy MH - Aged MH - *Individuality MH - *Overweight/psychology/therapy MH - Motivation MH - Iran PMC - PMC12038800 OTO - NOTNLM OT - Change strategies OT - Motivation OT - Personalized nutrition, OT - Processes OT - Readiness COIS- Competing Interests The authors report there are no competing interests to declare. EDAT- 2025/04/29 12:42 MHDA- 2025/04/29 12:43 PMCR- 2025/03/01 CRDT- 2025/04/29 06:05 PHST- 2024/11/18 00:00 [received] PHST- 2025/02/05 00:00 [accepted] PHST- 2025/04/29 12:43 [medline] PHST- 2025/04/29 12:42 [pubmed] PHST- 2025/04/29 06:05 [entrez] PHST- 2025/03/01 00:00 [pmc-release] AID - 10.34172/aim.33513 [doi] PST - ppublish SO - Arch Iran Med. 2025 Mar 1;28(3):162-170. doi: 10.34172/aim.33513. Epub 2025 Mar 1. PMID- 40297584 OWN - NLM STAT- MEDLINE DCOM- 20250429 LR - 20250508 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 16 DP - 2025 TI - Development and validation of novel models based on clonality immunoglobulin gene rearrangement for evaluation of bone marrow involvement and prognostic prediction in patients with diffuse large B-cell Lymphoma: a multicenter retrospective study. PG - 1547056 LID - 10.3389/fimmu.2025.1547056 [doi] LID - 1547056 AB - INTRODUCTION: Bone marrow involvement (BMI) is a poor prognostic factor in diffuse large B cell lymphoma (DLBCL), and accurate evaluation of BMI is crucial for determining stages and prognosis. This study aimed to identify the most effective examinations for evaluating BMI in DLBCL, including positron emission tomography-computed tomography (PET/CT), immunoglobulin gene rearrangement (IGR), flow cytometry (FCM), bone marrow cytology (BMC) and bone marrow biopsy pathology (BMB), and to further explore its prognostic significance in DLBCL patients. METHODS: This retrospective study included 364 newly diagnosed DLBCL patients, all of whom underwent PET/CT, IGR, FCM, BMC, and BMB at diagnosis. Survival outcomes were analyzed via Kaplan-Meier and Cox regression models. Novel prognostic models incorporating combined IGR and BMB results were developed in a training cohort. RESULTS: Compared to other detection methods, Clonal IGR BMI-positive were found the highest rate of 114 patients (31.3%), and IGR BM involvement-positive patients of DLBCL had the worst survival outcomes, especially among patients in stages I to III (P<0.001). Notably, PET/CT existed some limitations in BMI diagnosis, particularly in stage IV patients (P>0.05). Additionally, the combination of IGR and BMB demonstrated superior prognostic predictive capability for the patients in stage IV (PP<0.001). Multivariate analysis further confirmed that double-positive BMI of IGR and BMB was an independent prognostic factors of PFS (P=0.026) and OS (P=0.042). In addition, the novel IPI and NCCN-IPI stratification models were established by incorporating the combination of IGR and BMB in training group. The C-index of novel models were increased when IGR and BMB were supplemented in our cohort. DISCUSSION: Our results suggest that IGR is the most valuable methods for evaluating BMI compared to traditional detection methods. Adding the combination of IGR and BMB to the IPI and NCCN-IPI score may improve their predictive ability. In summary, IGR is essental for evaluation of BMI and provide an ideal method for disease staging and risk stratification in DLBCL patients in the rituximab era. CI - Copyright (c) 2025 Liu, Li, Liu, Ding, Liao, Hu, Pu, Zhu, Zhang and Xiong. FAU - Liu, Zelin AU - Liu Z AD - Hematological Lab, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. AD - Department of Hematology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Li, Qianping AU - Li Q AD - Institute of Hematology, Wenzhou Medical University, Wenzhou, Zhejiang, China. AD - Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. FAU - Liu, Ruiqi AU - Liu R AD - Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong, China. FAU - Ding, Yangyang AU - Ding Y AD - Hematological Lab, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. AD - Department of Hematology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Liao, Ya AU - Liao Y AD - Hematological Lab, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. AD - Department of Hematology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Hu, Linhui AU - Hu L AD - Hematological Lab, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. AD - Department of Hematology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Pu, Lianfang AU - Pu L AD - Hematological Lab, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. AD - Department of Hematology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Zhu, Chunhua AU - Zhu C AD - Air Force Health Care Center for Special Services, Hangzhou, Zhejiang, China. FAU - Zhang, Shenghui AU - Zhang S AD - Institute of Hematology, Wenzhou Medical University, Wenzhou, Zhejiang, China. AD - Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. FAU - Xiong, Shudao AU - Xiong S AD - Hematological Lab, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. AD - Department of Hematology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. AD - Research Center for Translational Medicine, The Second Hospital of Anhui Medical University, Hefei, Anhui, China. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20250414 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 SB - IM MH - Humans MH - *Lymphoma, Large B-Cell, Diffuse/genetics/mortality/pathology/diagnosis MH - Female MH - Male MH - Middle Aged MH - Retrospective Studies MH - Prognosis MH - Aged MH - *Bone Marrow/pathology MH - Adult MH - Positron Emission Tomography Computed Tomography MH - Aged, 80 and over MH - Young Adult MH - *Gene Rearrangement MH - *Genes, Immunoglobulin MH - Neoplasm Staging MH - Adolescent PMC - PMC12034632 OTO - NOTNLM OT - bone marrow biopsy pathology OT - bone marrow cytology OT - bone marrow involvement OT - diffuse large B cell lymphoma OT - flow cytometry OT - immunoglobulin gene rearrangement OT - positron emission tomography-computed tomography OT - prognostic model COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/04/29 06:25 MHDA- 2025/04/29 06:26 PMCR- 2025/01/01 CRDT- 2025/04/29 05:04 PHST- 2024/12/17 00:00 [received] PHST- 2025/03/26 00:00 [accepted] PHST- 2025/04/29 06:26 [medline] PHST- 2025/04/29 06:25 [pubmed] PHST- 2025/04/29 05:04 [entrez] PHST- 2025/01/01 00:00 [pmc-release] AID - 10.3389/fimmu.2025.1547056 [doi] PST - epublish SO - Front Immunol. 2025 Apr 14;16:1547056. doi: 10.3389/fimmu.2025.1547056. eCollection 2025. PMID- 40297037 OWN - NLM STAT- MEDLINE DCOM- 20250429 LR - 20250527 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - The effect of the social and interpersonal-based intervention on calcium consumption among pregnant women. PG - 1496028 LID - 10.3389/fpubh.2025.1496028 [doi] LID - 1496028 AB - INTRODUCTION: The present study aimed to evaluate the effect of educational intervention based on Pender's health promotion model on the calcium intake of pregnant women. METHODS: The pregnant women at three to 5 months were recruited using convenient sampling method and randomly assigned either to the control (n = 37) or intervention (n = 36) groups referred to the health centers in Kermanshah, "Iran," in 2022, 2023. Participants were randomly assigned to either the intervention group or the control group. The intervention consisted of a series of educational workshops that provided information on the importance of calcium, dietary sources, and practical methods for increasing calcium intake. Participants received personalized dietary plans, and improve knowledge, perceived benefits of action, perceived barriers to action, perceived self-efficacy, activity-related affect, interpersonal influences, situational influences, immediate competing demands and preferences, commitment to plan of action and over 8-week period, and ongoing support through one-month follow-up. The control group received standard prenatal care without additional nutritional education. Pre- and post-intervention assessments measured calcium intake and HPM constructs using validated questionnaires. The food frequency questionnaire was completed before and after the intervention. Data were analyzed in SPSS software version 25. RESULTS: There is no significant difference between the intervention and control groups at baseline (p < 0.05). According to the independent sample t-test, all constructs of the Pender's HPM except for interpersonal influences were significantly improved in the intervention rather than control groups (p > 0.05). The repeated measure ANOVA demonstrated a significant difference in the effect of the intervention on the constructs of the knowledge (F = 9.40; p-value = 0.001), perceived benefits (F = 17.24; p-value = 0.001), perceived barriers (F = 40.80; p-value = 0.001), perceived self-efficacy (F = 10.90; p-value = 0.001), activity-related affect (F = 14.85; p-value = 0.001), interpersonal influences (F = 21.51; p-value = 0.001), commitment to a plan of action (F = 20.20; p-value = 0.001), and immediate competing demands and preferences (F = 9.4; p-value = 0.001) between the intervention and control groups. The ANOVA demonstrated that the calcium consumption significantly increased in the intervention group (p < 0.001). DISCUSSION: A theory-based educational intervention in the health care system can fill the gap in the successful implementation of nutrition education programs. CI - Copyright (c) 2025 Heidari, Amiri, Rajati, Mahaki and Rajati. FAU - Heidari, Neda AU - Heidari N AD - Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran. FAU - Amiri, Masoomeh AU - Amiri M AD - Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran. FAU - Rajati, Fatemeh AU - Rajati F AD - Research Center for Environmental Determinants of Health, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. FAU - Mahaki, Behzad AU - Mahaki B AD - Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. FAU - Rajati, Mojgan AU - Rajati M AD - Department of Obstetrics and Gynecology, School of Medicine, Motazedi Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20250414 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - 0 (Calcium, Dietary) SB - IM MH - Humans MH - Female MH - Pregnancy MH - Adult MH - *Calcium, Dietary/administration & dosage MH - *Pregnant People/psychology MH - Iran MH - *Health Promotion/methods MH - Surveys and Questionnaires MH - Prenatal Care MH - Self Efficacy MH - Health Knowledge, Attitudes, Practice MH - *Health Education PMC - PMC12034691 OTO - NOTNLM OT - behavior change OT - calcium intake OT - health Promotion OT - health education OT - maternal and infant health OT - personal OT - social intervention OT - women COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2025/04/29 06:26 MHDA- 2025/04/29 12:42 PMCR- 2025/04/14 CRDT- 2025/04/29 04:55 PHST- 2024/09/13 00:00 [received] PHST- 2025/02/18 00:00 [accepted] PHST- 2025/04/29 12:42 [medline] PHST- 2025/04/29 06:26 [pubmed] PHST- 2025/04/29 04:55 [entrez] PHST- 2025/04/14 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1496028 [doi] PST - epublish SO - Front Public Health. 2025 Apr 14;13:1496028. doi: 10.3389/fpubh.2025.1496028. eCollection 2025. PMID- 40294505 OWN - NLM STAT- MEDLINE DCOM- 20250511 LR - 20260820 IS - 1873-2054 (Electronic) IS - 1353-8292 (Print) IS - 1353-8292 (Linking) VI - 93 DP - 2025 May TI - Neighborhood matters: An exploration of neighborhood-level disadvantage and cancer preventive behaviors in Hispanic youth with unhealthy weight. PG - 103474 LID - S1353-8292(25)00064-4 [pii] LID - 10.1016/j.healthplace.2025.103474 [doi] AB - OBJECTIVES: The present study aimed to assess the associations between the youth's cancer preventive behaviors (CPB) (i.e., healthy dietary intake and physical activity), parent stress, parent socio-demographic characteristics (i.e., education, household income, and marital status), and neighborhood influences measured by the Area Deprivation Index (ADI) in a sample of Hispanic families who have youth with unhealthy weight. Additionally, we examined whether parent stress mediated the relationship between ADI and youth CPB. METHODS: Baseline data from 280 Hispanic youth (M(age) = 13.01 +/- 0.83; 52.1 % females; M(Body Mass Index (BMI) Percentile) = 94.55 +/- 4.15) and their parents (M(age) = 41.87 +/- 6.49; 88.2 % females) who enrolled in an RCT were used. Self-reported data on youth dietary intake and physical activity, parent stress, and parent socio-demographic characteristics were collected. Neighborhood impact was examined using ADI, a validated measure to classify neighborhood disadvantage (e.g., housing quality and neighborhood income) using data from the US Census Bureau. Structural Equation Modeling was used (CPB as a latent variable) to evaluate the study model. RESULTS: Our findings indicated significant associations between ADI and youth CPB (b = -0.17, p = .019), and parent stress (b = 0.23, p = .001). However, parent stress did not mediate the relationship between youth ADI and CPB. CONCLUSION: Youth living in disadvantaged neighborhoods report less engagement in cancer preventive behaviors including poorer food intake quality and less physical activity, which may increase their risk of cancer. Future research should evaluate neighborhood resources to encourage physical activity and healthy eating. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - Lovan, Padideh AU - Lovan P AD - School of Nursing and Health Studies, University of Miami, Miami, FL, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA. Electronic address: phl31@med.miami.edu. FAU - Graefe, Beck AU - Graefe B AD - Department of Educational and Psychological Studies, University of Miami, Miami, FL, USA. FAU - Porter, Andrew AU - Porter A AD - School of Nursing and Health Studies, University of Miami, Miami, FL, USA. FAU - Szapocznik, Jose AU - Szapocznik J AD - Department of Public Health Sciences, University of Miami, Miami, FL, USA. FAU - Penedo, Frank J AU - Penedo FJ AD - Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA; Departments of Psychology and Medicine, University of Miami, Miami, FL, USA. FAU - Messiah, Sarah E AU - Messiah SE AD - Peter O'Donnell School of Public Health, The University of Texas Southwestern Medical Center, Dallas, TX, USA. FAU - Prado, Guillermo AU - Prado G AD - School of Nursing and Health Studies, University of Miami, Miami, FL, USA. LA - eng GR - R01 MD007724/MD/NIMHD NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20250427 PL - England TA - Health Place JT - Health & place JID - 9510067 SB - IM MH - Humans MH - Female MH - Male MH - Adolescent MH - *Hispanic or Latino/statistics & numerical data/psychology MH - Exercise MH - *Neoplasms/prevention & control MH - *Health Behavior MH - *Neighborhood Characteristics/statistics & numerical data MH - *Residence Characteristics/statistics & numerical data MH - Parents/psychology MH - Adult MH - Socioeconomic Factors MH - Stress, Psychological PMC - PMC12151268 MID - NIHMS2077704 OTO - NOTNLM OT - Cancer prevention OT - Good health and well-being OT - Hispanic youth OT - Neighborhood disadvantage OT - Reduced inequality OT - Risk behaviors COIS- Declarations of Interest: Authors have no conflict of interest to report. EDAT- 2025/04/29 00:28 MHDA- 2025/05/11 18:58 PMCR- 2026/05/01 CRDT- 2025/04/28 18:02 PHST- 2024/12/03 00:00 [received] PHST- 2025/03/30 00:00 [revised] PHST- 2025/04/23 00:00 [accepted] PHST- 2025/05/11 18:58 [medline] PHST- 2025/04/29 00:28 [pubmed] PHST- 2025/04/28 18:02 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - S1353-8292(25)00064-4 [pii] AID - 10.1016/j.healthplace.2025.103474 [doi] PST - ppublish SO - Health Place. 2025 May;93:103474. doi: 10.1016/j.healthplace.2025.103474. Epub 2025 Apr 27. PMID- 40292971 OWN - NLM STAT- MEDLINE DCOM- 20250428 LR - 20250430 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 25 IP - 6 DP - 2025 Mar 14 TI - Continuous Monitoring of Recruits During Military Basic Training to Mitigate Attrition. LID - 10.3390/s25061828 [doi] LID - 1828 AB - This paper explores the use of wearable technology (Garmin Fenix 7) to monitor physiological and psychological factors contributing to attrition during basic military training. Attrition, or the voluntary departure of recruits from the military, often results from physical and psychological challenges, such as fatigue, injury, and stress, which lead to significant costs for the military. To better understand and mitigate attrition, we designed and implemented a comprehensive and continuous data-capturing methodology to monitor 63 recruits during their basic infantry training. It's optimized for military use by being minimally invasive (for both recruits and operators), preventing data leakage, and being built for scale. We analysed data collected from two test phases, focusing on seven key psychometric and physical features derived from baseline questionnaires and physiological measurements from wearable devices. The preliminary results revealed that recruits at risk of attrition tend to cluster in specific areas of the feature space in both Linear Discriminant Analysis (LDA) and Principal Component Analysis (PCA). Key indicators of attrition included low motivation, low resilience, and a stress mindset. Furthermore, we developed a predictive model using physiological data, such as sleep scores and step counts from Garmin devices, achieving a macro mean absolute error (MAE) of 0.74. This model suggests the potential to reduce the burden of daily wellness questionnaires by relying on continuous, unobtrusive monitoring. FAU - Decorte, Robbe AU - Decorte R AUID- ORCID: 0000-0002-5788-7648 AD - IDLab, Ghent University-Imec, Technologiepark-Zwijnaarde 122, 9052 Ghent, Belgium. FAU - Vanhaeverbeke, Jelle AU - Vanhaeverbeke J AUID- ORCID: 0000-0002-6732-6502 AD - IDLab, Ghent University-Imec, Technologiepark-Zwijnaarde 122, 9052 Ghent, Belgium. FAU - VanDen Berghe, Sarah AU - VanDen Berghe S AUID- ORCID: 0009-0006-3214-5871 AD - Department of Rehabilitation Sciences, Ghent University, C. Heymanslaan 10, 9000 Ghent, Belgium. FAU - Slembrouck, Maarten AU - Slembrouck M AUID- ORCID: 0000-0002-1822-3881 AD - IDLab, Ghent University-Imec, Technologiepark-Zwijnaarde 122, 9052 Ghent, Belgium. FAU - Verstockt, Steven AU - Verstockt S AUID- ORCID: 0000-0003-1094-2184 AD - IDLab, Ghent University-Imec, Technologiepark-Zwijnaarde 122, 9052 Ghent, Belgium. LA - eng GR - 22DEFRA002/Belgian Ministry of Defence/ PT - Journal Article DEP - 20250314 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - *Military Personnel/psychology MH - *Wearable Electronic Devices MH - Monitoring, Physiologic/methods MH - Male MH - Surveys and Questionnaires MH - Adult MH - Female MH - Principal Component Analysis MH - Young Adult PMC - PMC11945558 OTO - NOTNLM OT - AI OT - attrition OT - continuous monitoring OT - data collection OT - military training OT - readiness-to-perform OT - risk prediction OT - smartwatch COIS- The authors declare no conflicts of interest. EDAT- 2025/04/28 12:30 MHDA- 2025/04/28 12:31 PMCR- 2025/03/14 CRDT- 2025/04/28 07:24 PHST- 2025/02/13 00:00 [received] PHST- 2025/03/12 00:00 [revised] PHST- 2025/03/13 00:00 [accepted] PHST- 2025/04/28 12:31 [medline] PHST- 2025/04/28 12:30 [pubmed] PHST- 2025/04/28 07:24 [entrez] PHST- 2025/03/14 00:00 [pmc-release] AID - s25061828 [pii] AID - sensors-25-01828 [pii] AID - 10.3390/s25061828 [doi] PST - epublish SO - Sensors (Basel). 2025 Mar 14;25(6):1828. doi: 10.3390/s25061828. PMID- 40292492 OWN - NLM STAT- MEDLINE DCOM- 20250428 LR - 20250430 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 6 DP - 2025 Mar 19 TI - Eating Disorder Risk Among Adolescents: The Influence of Dietary Patterns, Physical Activity, and BMI. LID - 10.3390/nu17061067 [doi] LID - 1067 AB - BACKGROUND/OBJECTIVES: Eating disorders (EDs) are rising among adolescents. BMI, diet, and physical activity influence ED risk, but their interactions are complex and vary by population. Considering sociocultural changes, this study investigated the prevalence and risk factors for EDs in Romanian adolescents. We evaluated demographic factors, BMI, dietary behaviors, physical activity (PA), and previous specialist consultations using the Eating Attitudes Test-26 (EAT-26) and assessed the psychometric properties of the EAT-26 in this population. METHODS: A cross-sectional study included 423 youths aged 13 to 20 from Cluj-Napoca. Participants completed an online survey on demographics, BMI, diet, physical activity, and previous health consultations. ED risk was assessed using the EAT-26. Confirmatory and exploratory factor analyses were conducted on the EAT-26, and binary logistic regression identified predictors of ED risk. RESULTS: The prevalence of ED risk was 26.5%, with females having 1.61 times higher odds than males. Consulting a weight or mental health specialist increased the odds of increased ED risk (OR = 3.76). Higher BMI showed a trend in the unadjusted model (OR = 1.06). An initial CFA of the EAT-26 showed a suboptimal fit. Over 60% of the sample reported frequent consumption of ultra-processed foods. CONCLUSIONS: Our findings highlight a significant ED risk in Romanian youth, filling a critical gap in regional public health evidence. Despite limitations due to the cross-sectional design and self-reported data, the results stress the need for measures promoting balanced diets, positive body image, and improved mental health access to reduce the growing prevalence of adolescent ED risk in Romania. FAU - Ispas, Anca Georgiana AU - Ispas AG AUID- ORCID: 0009-0003-6980-5253 AD - Department of Public Health, College of Political, Administrative and Communication Sciences, Babes-Bolyai University, 400376 Cluj-Napoca, Romania. AD - Asociatia Wello, 400686 Cluj-Napoca, Romania. FAU - Forray, Alina Ioana AU - Forray AI AD - Department of Public Health, College of Political, Administrative and Communication Sciences, Babes-Bolyai University, 400376 Cluj-Napoca, Romania. AD - Discipline of Public Health and Management, Department of Community Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania. FAU - Lacurezeanu, Alexandra AU - Lacurezeanu A AD - Asociatia Wello, 400686 Cluj-Napoca, Romania. AD - Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania. FAU - Petreus, Dumitru AU - Petreus D AD - Asociatia Wello, 400686 Cluj-Napoca, Romania. FAU - Gavrilas, Laura Ioana AU - Gavrilas LI AD - Department 2, Faculty of Nursing and Health Sciences, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania. FAU - Chereches, Razvan Mircea AU - Chereches RM AD - Department of Public Health, College of Political, Administrative and Communication Sciences, Babes-Bolyai University, 400376 Cluj-Napoca, Romania. LA - eng GR - IMG-23-006/Botnar Foundation/ PT - Journal Article DEP - 20250319 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - Cross-Sectional Studies MH - *Exercise MH - *Body Mass Index MH - *Feeding and Eating Disorders/epidemiology/etiology MH - Risk Factors MH - Romania/epidemiology MH - *Diet MH - *Feeding Behavior MH - Prevalence MH - Young Adult MH - Surveys and Questionnaires PMC - PMC11946152 OTO - NOTNLM OT - Romania OT - adolescent OT - body image OT - body mass index OT - dietary habits OT - eating disorders OT - health promotion OT - mediterranean diet OT - mental health OT - physical activity OT - processed foods OT - weight perception COIS- The authors declare no conflict of interest. EDAT- 2025/04/28 12:29 MHDA- 2025/04/28 12:30 PMCR- 2025/03/19 CRDT- 2025/04/28 06:46 PHST- 2025/02/12 00:00 [received] PHST- 2025/03/10 00:00 [revised] PHST- 2025/03/13 00:00 [accepted] PHST- 2025/04/28 12:30 [medline] PHST- 2025/04/28 12:29 [pubmed] PHST- 2025/04/28 06:46 [entrez] PHST- 2025/03/19 00:00 [pmc-release] AID - nu17061067 [pii] AID - nutrients-17-01067 [pii] AID - 10.3390/nu17061067 [doi] PST - epublish SO - Nutrients. 2025 Mar 19;17(6):1067. doi: 10.3390/nu17061067. PMID- 40292009 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260925 IS - 2398-502X (Print) IS - 2398-502X (Electronic) IS - 2398-502X (Linking) VI - 9 DP - 2024 TI - Evaluation of a six-minute walk test in the DE50-MD canine model of Duchenne muscular dystrophy and its effect on blood-borne biomarkers. PG - 681 LID - 10.12688/wellcomeopenres.23269.2 [doi] LID - 681 AB - BACKGROUND: Duchenne muscular dystrophy (DMD) is a fatal muscle wasting disease caused by mutations in the dystrophin gene resulting in cycles of muscle degeneration, inflammation and regeneration. The 6-minute walk test (6MWT) is a key functional outcome measure for DMD patient clinical trials and has been adapted for use in animal models of the disease. The DE50-MD dog model of DMD closely reflects the DMD patient phenotype prior to loss of ambulation. For pre-clinical trials using this model, functional outcome measures must be established. METHODS: This longitudinal study compared distance walked in a 6MWT by DE50-MD and WT control dogs and assessed the utility of the 6MWT as a functional biomarker. Dogs underwent two 6MWTs conducted approximately 48-hours apart, at 3, 6, 9, 12, 15 and 18 months of age. In addition, we evaluated the stability of selected blood-borne biomarkers in 12-month old DE50-MD and WT dogs 0, 3, 6, 24 and 48 hours following a 6MWT. RESULTS: DE50-MD dogs exhibited significantly shorter 6-minute walk distance (6MWD) than WT dogs at all timepoints (P<0.05), with no difference in 6MWD between the first and second 6MWT. C-C motif chemokine ligand 2 (CCL2), myomesin-3 (MYOM3) and myostatin (MSTN) were biomarkers of the DE50-MD phenotype that remained unchanged in DE50-MD dogs following the 6MWT, while creatine kinase (CK) activity significantly increased 3-hours following the test in DE50-MD dogs but remained unchanged in WT dogs. CONCLUSIONS: The 6MWT effectively discriminates DE50-MD from WT dogs aged 3-18 months and a single 6MWT is sufficient for future studies. Serum MYOM3, CCL2 and MSTN are good biomarkers of the DE50-MD phenotype that are unaffected by the relatively low level exertion performed in the 6MWT by 12-month-old DE50-MD dogs. CI - Copyright: (c) 2025 Riddell D et al. FAU - Riddell, Dominique AU - Riddell D AUID- ORCID: 0000-0002-1614-504X AD - Comparative Neuromuscular Diseases Laboratory, Clinical Sciences and Services, Royal College Street, London, NW1 0TU, UK. FAU - Harron, Rachel AU - Harron R AD - Comparative Neuromuscular Diseases Laboratory, Clinical Sciences and Services, Royal College Street, London, NW1 0TU, UK. FAU - Hildyard, John AU - Hildyard J AUID- ORCID: 0000-0003-2283-2118 AD - Comparative Neuromuscular Diseases Laboratory, Clinical Sciences and Services, Royal College Street, London, NW1 0TU, UK. FAU - Wells, Dominic AU - Wells D AUID- ORCID: 0000-0002-1425-6344 AD - Comparative Biomedical Sciences, The Royal Veterinary College, Royal College Street, London, NW1 0TU, UK. FAU - Piercy, Richard AU - Piercy R AUID- ORCID: 0000-0002-4344-6438 AD - Comparative Neuromuscular Diseases Laboratory, Clinical Sciences and Services, Royal College Street, London, NW1 0TU, UK. LA - eng SI - figshare/10.6084/m9.figshare.27135216 GR - WT_/Wellcome Trust/United Kingdom PT - Journal Article DEP - 20250317 PL - England TA - Wellcome Open Res JT - Wellcome open research JID - 101696457 PMC - PMC12022548 OAB - Duchenne muscular dystrophy (DMD) is a fatal muscle wasting disease caused by mutations in the dystrophin gene resulting in cycles of muscle damage, inflammation and repair. The 6-minute walk test (6MWT) is an assessment that measures the distance that a DMD patient can walk in 6 minutes; as the disease becomes more severe with age, affected boys walk progressively shorter distances as muscle function declines. The 6MWT has also been used in animal models of DMD for pre-clinical trials. One such model is the DE50-MD dog model, which has musculoskeletal features that reflect the symptoms manifested by ambulant human DMD patients. In order to use this animal model to trial treatments, functional testing must first be validated. In this study, we compared the distance walked in a 6MWT by DE50-MD and healthy control dogs aged between 3- and 18-months to assess the test's potential as a measure of muscle function. In addition, we examined the effect of the exercise test on levels of certain blood-borne disease biomarkers. DE50-MD dogs walked shorter distances than the healthy control dogs at all ages. Several blood-borne biomarkers remained stable following the 6MWT (C-C motif chemokine ligand 2 (CCL2), myomesin-3 (MYOM3) and myostatin (MSTN)), while others (such as creatine kinase (CK) activity) increased in the DE50-MD dogs. We conclude that the distance walked during a 6MWT is suitable as a measure of muscle function for future treatment trials using this canine model. OABL- eng OTO - NOTNLM OT - 6MWT OT - DE50-MD OT - DMD OT - Duchenne OT - biomarkers OT - dog model OT - exercise OT - serum COIS- Competing interests: R.J.P. has received funding for separate research programmes from Pfizer, Exonics Therapeutics, Capacity Bio and has been a consultant to Exonics Therapeutics; the financial interests were reviewed and approved by the Royal Veterinary College in accordance with conflict-of-interest policies. D.J.W. is or has been a consultant to a wide range of companies with interests in the DMD space, including Pfizer, Sarepta, Akashi and Actual Analytics. Studies in his lab have been funded by Proximagen and Shire. EDAT- 2025/04/28 17:04 MHDA- 2025/04/28 17:05 PMCR- 2025/03/17 CRDT- 2025/04/28 06:39 PHST- 2025/03/11 00:00 [accepted] PHST- 2025/04/28 17:05 [medline] PHST- 2025/04/28 17:04 [pubmed] PHST- 2025/04/28 06:39 [entrez] PHST- 2025/03/17 00:00 [pmc-release] AID - 10.12688/wellcomeopenres.23269.2 [doi] PST - epublish SO - Wellcome Open Res. 2025 Mar 17;9:681. doi: 10.12688/wellcomeopenres.23269.2. eCollection 2024. PMID- 40290507 OWN - NLM STAT- MEDLINE DCOM- 20250428 LR - 20250429 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - The impact of physical activities on cognitive function among older adult populations: evidence from China. PG - 1562747 LID - 10.3389/fpubh.2025.1562747 [doi] LID - 1562747 AB - OBJECTIVE: This study investigates the impact of physical activity on cognitive function in Chinese middle-aged and older adult individuals, examining the relationship between different intensities of physical activity and cognitive function, as well as the effect of physical activity on various types of cognitive function. METHOD: A total of 27,529 samples were selected from the China Health and Retirement Longitudinal Study (CHARLS) data from 2011 to 2018 for regression analysis. Multidimensional fixed effects estimation was used to validate the impact of physical activity on cognitive function in middle-aged and older adults, analyzing differences in the intensity of physical activity and types of cognitive function. The empirical results were further tested using methods such as propensity score matching (PSM). Additionally, this paper conducted heterogeneity analyses by gender, place of residence, presence of children, and marital status. RESULTS: Physical activity had a positive impact on cognitive function among middle-aged and older adults in China by improving their cardiovascular health, and this result held true regardless of gender, rural or urban residence, presence of children, or marital status. This conclusion was supported by both alternative explanatory variables and results from propensity score matching. Further research found that physical activity improves immediate memory and delayed recall among middle-aged and older adults. Moderate physical activity enhances the health of the older adult population, whereas excessive physical activity may impair cognitive function in middle-aged and older adults. CONCLUSION: Our study found that PA can effectively promote the improvement of cognitive function in middle-aged and older adults, with this conclusion still holding true in older populations. Such physical activity should be moderate, because vigorous physical activity may impair cognitive function in middle-aged and older people. The study conclusions play a significant role in promoting physical activity, delaying cognitive decline, achieving active aging, and reducing the burden of informal caregiving. CI - Copyright (c) 2025 Chen, Yang and Liu. FAU - Chen, Xiao AU - Chen X AD - School of Sports Training, Tianjin University of Sport, Tianjin, China. AD - Department of Physical Education, Zhongnan University of Economics and Law, Wuhan, China. FAU - Yang, Qishun AU - Yang Q AD - School of Physical Education and Equestrian, Wuhan Business University, Wuhan, China. FAU - Liu, ZhiYun AU - Liu Z AD - School of Sports Training, Tianjin University of Sport, Tianjin, China. LA - eng PT - Journal Article DEP - 20250411 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - China MH - Male MH - *Exercise/physiology MH - Female MH - *Cognition/physiology MH - Aged MH - Middle Aged MH - Longitudinal Studies MH - Propensity Score PMC - PMC12021623 OTO - NOTNLM OT - CHARLS OT - cognition OT - fixed effects regression OT - middle-aged and older adults OT - physical activity COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/04/28 17:04 MHDA- 2025/04/28 17:05 PMCR- 2025/04/11 CRDT- 2025/04/28 06:20 PHST- 2025/01/18 00:00 [received] PHST- 2025/03/19 00:00 [accepted] PHST- 2025/04/28 17:05 [medline] PHST- 2025/04/28 17:04 [pubmed] PHST- 2025/04/28 06:20 [entrez] PHST- 2025/04/11 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1562747 [doi] PST - epublish SO - Front Public Health. 2025 Apr 11;13:1562747. doi: 10.3389/fpubh.2025.1562747. eCollection 2025. PMID- 40287063 OWN - NLM STAT- MEDLINE DCOM- 20250712 LR - 20250721 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 68 DP - 2025 Aug TI - Internal validation of two nutritional screening tools in hospitalized children and adolescents with cancer. PG - 47-54 LID - S2405-4577(25)00276-1 [pii] LID - 10.1016/j.clnesp.2025.04.007 [doi] AB - BACKGROUND & AIMS: In cancer patients, malnutrition is associated with poorer treatment outcomes and prolonged hospital stays, negatively affecting prognosis and survival. This study aimed to evaluate the internal validity of the nutritional screening tools Nutrition Screening Tool for Childhood Cancer (SCAN) and Screening Tool Risk on Nutritional Status and Growth (STRONGKids) in predicting nutritional risk in hospitalized pediatric cancer patients. METHODS: This was a retrospective observational study with pediatric cancer patients hospitalized between February and November 2019. ANPEDCancer was used as a reference to validate SCAN and STRONGKids due to its specificity in nutritional assessment for children and adolescents with cancer. Predictive values and agreement were analyzed. Patients were classified as at nutritional risk or not based on the tools. Nutritional status, anthropometric measures, biochemical markers, and length of stay (LOS) were compared between groups. RESULTS: Of the 111 patients, 75.7 % (n = 84) were classified as at nutritional risk by SCAN, and 34.2 % (n = 38) as at high risk by STRONGKids. Patients at risk showed greater inadequacy in body composition measures and anthropometric indices. There was an association between nutritional risk as classified by the screening tools and the reduction of lean mass reserves (p = 0.039) and adipose tissue (p = 0.017). C-reactive protein was associated with nutritional risk only in STRONGKids, and with LOS only in SCAN. The agreement was 79.27 % for SCAN and 72.07 % for STRONGKids. CONCLUSION: The SCAN demonstrated good precision in the nutritional screening of children with cancer, while STRONGKids was associated with inflamation. CI - Copyright (c) 2025 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. FAU - Paixao, Isabela Barroso AU - Paixao IB AD - Dietitian. Multiprofessional Residency Program in Oncology of the National Cancer Institute (INCA), Pr. da Cruz Vermelha, 23 - Centro, Rio de Janeiro, RJ, 20230-130, Brazil. Electronic address: isabelaa.barroso@gmail.com. FAU - Carvalho, Beatriz Pereira de AU - Carvalho BP AD - Dietitian. Nutrition Institute, State University of Rio de Janeiro (UERJ), Rua Sao Francisco Xavier, 524, Pavilhao Joao Lyra Filho, 20559-900, Rio de Janeiro, Brazil. Electronic address: biapcarvalho8@gmail.com. FAU - Murad, Luana Dalbem AU - Murad LD AD - Dietitian and Research. Nutrition and Dietetic Sector, Cancer Hospital Unit I, National Cancer Institute (INCA), Pr. da Cruz Vermelha, 23 - Centro, Rio de Janeiro, RJ, 20230-130, Brazil. Electronic address: luana.murad@mail.com. FAU - Saraiva, Danubia da Cunha Antunes AU - Saraiva DDCA AD - Dietitian and Research. Nutrition and Dietetic Sector, Cancer Hospital Unit I, National Cancer Institute (INCA), Pr. da Cruz Vermelha, 23 - Centro, Rio de Janeiro, RJ, 20230-130, Brazil. Electronic address: danubia.saraiva@inca.gov.br. LA - eng PT - Journal Article PT - Observational Study PT - Validation Study DEP - 20250424 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM MH - Humans MH - *Neoplasms/complications MH - Child MH - Adolescent MH - Male MH - Female MH - *Nutrition Assessment MH - Retrospective Studies MH - Nutritional Status MH - *Malnutrition/diagnosis/etiology MH - Child, Preschool MH - Hospitalization MH - Child, Hospitalized MH - *Mass Screening/methods MH - Length of Stay MH - Reproducibility of Results MH - Body Composition OTO - NOTNLM OT - Cancer OT - Data accuracy OT - Nutritional status OT - Pediatrics OT - Screening COIS- Declaration of competing interest The authors declare no conflicts of interest. EDAT- 2025/04/27 03:14 MHDA- 2025/07/13 03:36 CRDT- 2025/04/26 19:36 PHST- 2024/09/27 00:00 [received] PHST- 2025/03/24 00:00 [revised] PHST- 2025/04/15 00:00 [accepted] PHST- 2025/07/13 03:36 [medline] PHST- 2025/04/27 03:14 [pubmed] PHST- 2025/04/26 19:36 [entrez] AID - S2405-4577(25)00276-1 [pii] AID - 10.1016/j.clnesp.2025.04.007 [doi] PST - ppublish SO - Clin Nutr ESPEN. 2025 Aug;68:47-54. doi: 10.1016/j.clnesp.2025.04.007. Epub 2025 Apr 24. PMID- 40286631 OWN - NLM STAT- MEDLINE DCOM- 20250516 LR - 20260717 IS - 1873-2380 (Electronic) IS - 0021-9290 (Linking) VI - 186 DP - 2025 Jun TI - From marker to markerless: Validating DeepLabCut for 2D sagittal plane gait analysis in adults and newly walking toddlers. PG - 112708 LID - S0021-9290(25)00220-9 [pii] LID - 10.1016/j.jbiomech.2025.112708 [doi] AB - The use of 3D marker-based motion analysis systems is considered the gold standard for tracking limb movements. However, these systems are expensive, limited to laboratory settings, and difficult to apply when studying paediatric populations. Therefore, this study investigated the validity of a markerless motion tracking software, DeepLabCut, in extracting kinematics from 2D sagittal plane videos of adults and toddlers during walking. Data were obtained from fifteen toddlers performing their first independent steps and sixteen healthy adults. Participants performed overground and treadmill walking at comfortable pace. Distinct models with either 25% or 75% of participants as input were used for DeepLabCut network training. For all participants, anatomical landmarks extracted through video analysis in DeepLabCut were used to calculate lower-limb gait kinematics, which were compared to kinematics computed using a 3D marker-based system (Vicon). The 25% models performed well for adult joint angles, but not for clinical parameters or toddlers. In both populations, the 75% models showed good (>/=0.60) or excellent (>/=0.75) intraclass correlation coefficient absolute agreement for most time-normalized joint angles and clinical parameters. This improvement was supported by increased Pearson's correlation coefficients, decreased root mean squared errors, and increased R(2) values from the 25% to the 75% models. More specifically, higher validity of DeepLabCut was found for adults compared to toddlers and treadmill compared to overground walking. Altogether, with sufficiently diverse input, DeepLabCut proved a valid tool to acquire gait kinematics in known scenarios, with the potential to study typical adult and toddler gait in more ecological and naturalistic environments. CI - Copyright (c) 2025 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Verhoeven, Michelle AU - Verhoeven M AD - Department of Rehabilitation Sciences, Faculty of Medicine and Health Science, Ghent University, Ghent, Belgium; Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Movement Sciences, Rehabilitation & Development, Amsterdam, the Netherlands; Institute for Brain and Behavior Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Electronic address: michelle.verhoeven@ugent.be. FAU - Zandvoort, Coen S AU - Zandvoort CS AD - Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Movement Sciences, Rehabilitation & Development, Amsterdam, the Netherlands; Institute for Brain and Behavior Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Department of Paediatrics, University of Oxford, Oxford, United Kingdom. Electronic address: coen.zandvoort@paediatrics.ox.ac.uk. FAU - Dominici, Nadia AU - Dominici N AD - Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Movement Sciences, Rehabilitation & Development, Amsterdam, the Netherlands; Institute for Brain and Behavior Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Electronic address: n.dominici@vu.nl. LA - eng PT - Journal Article PT - Validation Study DEP - 20250418 PL - United States TA - J Biomech JT - Journal of biomechanics JID - 0157375 SB - IM MH - Humans MH - Biomechanical Phenomena MH - Male MH - Female MH - Adult MH - *Walking/physiology MH - *Gait Analysis/methods MH - Child, Preschool MH - *Gait/physiology MH - Software MH - Young Adult MH - Infant MH - Video Recording OTO - NOTNLM OT - Biomechanics OT - Deep learning OT - DeepLabCut OT - Gait analysis OT - Markerless motion capture OT - Toddlers COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/04/27 03:14 MHDA- 2025/05/17 17:03 CRDT- 2025/04/26 18:09 PHST- 2024/12/13 00:00 [received] PHST- 2025/04/01 00:00 [revised] PHST- 2025/04/15 00:00 [accepted] PHST- 2025/05/17 17:03 [medline] PHST- 2025/04/27 03:14 [pubmed] PHST- 2025/04/26 18:09 [entrez] AID - S0021-9290(25)00220-9 [pii] AID - 10.1016/j.jbiomech.2025.112708 [doi] PST - ppublish SO - J Biomech. 2025 Jun;186:112708. doi: 10.1016/j.jbiomech.2025.112708. Epub 2025 Apr 18. PMID- 40284261 OWN - NLM STAT- MEDLINE DCOM- 20250426 LR - 20250428 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 8 DP - 2025 Apr 21 TI - Multiomics Analysis of a Micronutrient-Rich Dietary Pattern and the Aging Genotype 9p21 on the Plasma Proteome of Young Adults. LID - 10.3390/nu17081398 [doi] LID - 1398 AB - Background: Diet is one of the most significant modifiable lifestyle factors influencing human health, contributing to both morbidity and mortality. Genetic variations in the pleiotropic 9p21 risk locus further shape premature aging, disease susceptibility, and have been strongly linked to cardiovascular disease (CVD), metabolic disorders, certain cancers, and neurodegenerative conditions. However, given that this region was discovered based on Genome-Wide Association Studies, the mechanisms by which 9p21 exerts its effects remain poorly understood and its interactions with diet and biomarkers are insufficiently explored. Methods: This study investigated the association between the rs2383206 SNP in 9p21, dietary patterns, and plasma proteomic biomarkers in a multi-ethnic cohort of 1280 young adults from the Toronto Nutrigenomics and Health Study. Participants' dietary intake was assessed using a validated food frequency questionnaire, and dietary patterns were categorized using principal component analysis. Plasma proteomics analyses quantified 54 abundant proteins involved in the cardiometabolic and inflammatory pathways. Genotyping identified individuals who were homozygous for the 9p21 risk allele (GG), known to confer the highest susceptibility risk to premature aging and multiple chronic diseases. Results: A significant interaction was observed between the 9p21 genotype and adherence to a micronutrient-rich Prudent dietary pattern for eight plasma proteins (alpha(1) Antichymotrypsin, Complement C4 beta chain, Complement C4 gamma chain, Complement C9, Fibrinogen alpha chain, Hemopexin, and Serum amyloid P-component). However, only Complement C4-gamma showed a pattern consistent with the risks associated with the 9p21 genotype and adherence to a Prudent diet. Individuals with the high-risk GG genotype had significantly higher concentrations of Complement C4-gamma, but only among those with a low adherence to a Prudent diet. Conclusions: These findings suggest that Prudent dietary patterns rich in micronutrients may counteract genetic-mediated proinflammatory susceptibility by modulating key proteomic biomarkers in young adults, highlighting the potential for tailored dietary interventions to mitigate disease risk. This study also introduces a novel framework for post hoc micronutrient resolution within dietary pattern analysis, offering a new lens to interpret nutrient synergies in gene-diet interaction research. FAU - Mahdavi, Sara AU - Mahdavi S AUID- ORCID: 0000-0002-4977-0431 AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, 6 Queens Park Crescent, Toronto, ON M5S 3H2, Canada. AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, 677 Huntington Ave, Building B, Room 359, Boston, MA 02115, USA. FAU - Rosychuk, Katie AU - Rosychuk K AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, 6 Queens Park Crescent, Toronto, ON M5S 3H2, Canada. FAU - Jenkins, David J A AU - Jenkins DJA AUID- ORCID: 0000-0003-1192-9571 AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, 6 Queens Park Crescent, Toronto, ON M5S 3H2, Canada. AD - Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON M5B 1W8, Canada. AD - Division of Endocrinology and Metabolism, Department of Medicine, St. Michael's Hospital, Toronto, ON M5B 1W8, Canada. AD - Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada. AD - Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON M5B 1W8, Canada. FAU - Percy, Andrew J AU - Percy AJ AD - Genome BC Proteomics Centre, University of Victoria, Victoria, BC V8Z 7X8, Canada. AD - Department of Applications Development, Cambridge Isotope Laboratories, Inc., Tewksbury, MA 01876, USA. FAU - Borchers, Christoph H AU - Borchers CH AUID- ORCID: 0000-0003-2394-6512 AD - Segal Cancer Proteomics Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada. AD - Gerald Bronfman Department of Oncology, McGill University, Montreal, QC H3T 1E2, Canada. AD - Department of Pathology, McGill University, Montreal, QC H3T 1E2, Canada. AD - Division of Experimental Medicine, McGill University, Montreal, QC H3T 1E2, Canada. FAU - El-Sohemy, Ahmed AU - El-Sohemy A AUID- ORCID: 0000-0002-8877-6414 AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, 6 Queens Park Crescent, Toronto, ON M5S 3H2, Canada. LA - eng GR - IT05403/Mitacs-Accelerate Graduate Research Internship Program/ GR - no/Advanced Foods and Materials Network (AFMNet)/ PT - Journal Article DEP - 20250421 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Micronutrients) RN - 0 (Proteome) RN - 0 (Biomarkers) RN - 0 (Blood Proteins) SB - IM MH - Humans MH - Male MH - Female MH - Young Adult MH - Polymorphism, Single Nucleotide MH - *Micronutrients/administration & dosage MH - Genotype MH - *Proteome MH - Adult MH - *Chromosomes, Human, Pair 9/genetics MH - Biomarkers/blood MH - *Diet MH - *Aging/genetics MH - *Blood Proteins MH - Proteomics MH - Nutrigenomics MH - Adolescent MH - Genome-Wide Association Study MH - Multiomics PMC - PMC12030164 OTO - NOTNLM OT - 9p21 genetic variant OT - complement C4-gamma OT - dietary patterns OT - gene-diet interaction OT - micronutrients OT - plasma proteomics COIS- S.M. has received funding for advisory board activities, consulting roles, educational grants, travel grants, and speaker/moderator honoraria from the American Academy of Nutrition, World Congress of Aesthetics and Anti-Aging Medicine, Canadian Board of Aesthetic Medicine, Canadian Association of Medical Aesthetics, Canadian Association of Aesthetic Medicine, Los Angeles Multi-Specialty Cosmetic Academy, Allergan, Galderma, Sanofi, Shire, Genzyme, Gambro, Nutrigenomix, and Abbott. S.M. has received fellowship, educational, and research funding from Harvard University, the University of Toronto, and Mitacs. S.M. has provided in-kind educational speaker services to the University of Miami Dermatology Department and has served on the Editorial Board of the Canadian Journal of Kidney Disease and Health, the official journal of the Canadian Society of Nephrology. S.M. is an associate editor of the Canadian Journal of Kidney Disease and Health and an assistant editor of BMJ Nutrition, Prevention & Health. A.E.-S. is the founder and holds shares in Nutrigenomix Inc. C.B. is a Scientific Advisor at MRM Proteomics Inc. and the VP of Proteomics at Molecular You. S.M. and D.J. serve on the Internation Scientific Advisory Board of Nutrigenomix Inc. D.J.A.J. has not received industrial research funding for the last 10 years. He received travel and accommodation support, payment, or honoraria for lectures/presentations from Lawson Centre Nutrition Digital Series, 19th Annual Stare-Hegsted Lecture, 2024 Diabetes Canada Conference. His wife, Alexandra L Jenkins, is a director and partner of INQUIS Clinical Research for the Food Industry, and his two daughters, Wendy Jenkins and Amy Jenkins, have published a vegetarian book that promotes the use of the foods described here: The Portfolio Diet for Cardiovascular Disease Risk Reduction (Academic Press/Elsevier 2020 ISBN:978-0-12-810510-8). K.R. and A.J.P. have no conflicts of interest to declare. EDAT- 2025/04/26 16:16 MHDA- 2025/04/26 16:17 PMCR- 2025/04/21 CRDT- 2025/04/26 01:17 PHST- 2025/03/25 00:00 [received] PHST- 2025/04/15 00:00 [revised] PHST- 2025/04/17 00:00 [accepted] PHST- 2025/04/26 16:17 [medline] PHST- 2025/04/26 16:16 [pubmed] PHST- 2025/04/26 01:17 [entrez] PHST- 2025/04/21 00:00 [pmc-release] AID - nu17081398 [pii] AID - nutrients-17-01398 [pii] AID - 10.3390/nu17081398 [doi] PST - epublish SO - Nutrients. 2025 Apr 21;17(8):1398. doi: 10.3390/nu17081398. PMID- 40284235 OWN - NLM STAT- MEDLINE DCOM- 20250426 LR - 20250428 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 8 DP - 2025 Apr 18 TI - Association of Prenatal Healthy and Unhealthy Plant-Based Diets with Behavioral Outcomes in Preschool Children. LID - 10.3390/nu17081372 [doi] LID - 1372 AB - BACKGROUND/OBJECTIVES: Dietary patterns rich in plant-based foods during pregnancy have been associated with neurodevelopmental outcomes in offspring. However, not all components of these diets are healthy, and the impact of their quality on behavioral outcomes remains unexplored. Therefore, this study aimed to examine the association between healthy and unhealthy plant-based diets and offspring behavioral problems at the age of four. METHODS: This research involved 201 mother-child pairs from the ECLIPSES study. Maternal diet during pregnancy was assessed using a validated food frequency questionnaire, from which the healthy plant-based diet index (hPDI) was calculated, emphasizing the consumption of fruits, vegetables, legumes and nuts, along with the unhealthy plant-based diet index (uPDI), highlighting the intake of sugary drinks and refined grains. Children's behavior was evaluated using the Child Behavior Checklist 1.5-5. Multivariable logistic regression analyses were conducted to estimated odds ratios (ORs) and their 95% confidence intervals (CIs). RESULTS: Greater adherence to the uPDI during pregnancy was associated with higher odds for externalizing problems, including attention-deficit/hyperactivity problems (OR = 1.08; 95%CI from 1.01 to 1.16) and oppositional defiant behavior (OR = 1.09; 95%CI from 1.00 to 1.19) in offspring, particularly girls. Higher adherence to the hPDI was not associated with children's behavior. CONCLUSIONS: The consumption of unhealthy components of a plant-based dietary pattern during gestation has been associated with adverse behavioral outcomes in children at age four. These findings underscore the importance of discerning between the healthy and unhealthy components of plant-based diets when assessing their impact on child development. FAU - Cendra-Duarte, Esther AU - Cendra-Duarte E AUID- ORCID: 0000-0001-8593-9401 AD - Universitat Rovira i Virgili, Nutrition and Mental Health (NUTRISAM) Research Group, 43204 Reus, Spain. AD - Collaborative Group on Lifestyles, Nutrition, and Tobacco (CENIT), Institut d'Investigacio en Atencio Primaria IDIAP Jordi Gol, Institut Catala de la Salut (ICS), 43202 Reus, Spain. FAU - Becerra-Tomas, Nerea AU - Becerra-Tomas N AD - Universitat Rovira i Virgili, Nutrition and Mental Health (NUTRISAM) Research Group, 43204 Reus, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), 43003 Tarragona, Spain. FAU - Canals, Josefa AU - Canals J AUID- ORCID: 0000-0002-6209-9558 AD - Universitat Rovira i Virgili, Nutrition and Mental Health (NUTRISAM) Research Group, 43204 Reus, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), 43003 Tarragona, Spain. AD - Universitat Rovira i Virgili, Department of Psychology, Centre de Recerca en Avaluacio i Mesura de la Conducta (CRAMC), 43007 Tarragona, Spain. FAU - Jardi, Cristina AU - Jardi C AUID- ORCID: 0000-0002-7946-1488 AD - Universitat Rovira i Virgili, Nutrition and Mental Health (NUTRISAM) Research Group, 43204 Reus, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), 43003 Tarragona, Spain. FAU - Arija, Victoria AU - Arija V AUID- ORCID: 0000-0002-1758-0975 AD - Universitat Rovira i Virgili, Nutrition and Mental Health (NUTRISAM) Research Group, 43204 Reus, Spain. AD - Collaborative Group on Lifestyles, Nutrition, and Tobacco (CENIT), Institut d'Investigacio en Atencio Primaria IDIAP Jordi Gol, Institut Catala de la Salut (ICS), 43202 Reus, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), 43003 Tarragona, Spain. LA - eng GR - PI12/02777/Instituto de Salud Carlos III/ GR - PI17/01754/Instituto de Salud Carlos III/ PT - Journal Article DEP - 20250418 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Child, Preschool MH - Male MH - *Diet, Healthy MH - *Child Behavior MH - *Diet, Vegetarian/adverse effects MH - Adult MH - *Maternal Nutritional Physiological Phenomena MH - *Prenatal Exposure Delayed Effects MH - Diet, Plant-Based PMC - PMC12030138 OTO - NOTNLM OT - child OT - child behavior OT - maternal diet OT - neurodevelopment OT - plant-based diets OT - pregnancy COIS- The authors declare no conflicts of interest. EDAT- 2025/04/26 16:09 MHDA- 2025/04/26 16:44 PMCR- 2025/04/18 CRDT- 2025/04/26 01:16 PHST- 2025/03/18 00:00 [received] PHST- 2025/04/14 00:00 [revised] PHST- 2025/04/17 00:00 [accepted] PHST- 2025/04/26 16:44 [medline] PHST- 2025/04/26 16:09 [pubmed] PHST- 2025/04/26 01:16 [entrez] PHST- 2025/04/18 00:00 [pmc-release] AID - nu17081372 [pii] AID - nutrients-17-01372 [pii] AID - 10.3390/nu17081372 [doi] PST - epublish SO - Nutrients. 2025 Apr 18;17(8):1372. doi: 10.3390/nu17081372. PMID- 40284192 OWN - NLM STAT- MEDLINE DCOM- 20250426 LR - 20250428 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 8 DP - 2025 Apr 11 TI - Food Neophobia in Brazilian Children: A Nationwide Cross-Sectional Study Comparing Neurodivergent and Neurotypical Children with and Without Dietary Restrictions. LID - 10.3390/nu17081327 [doi] LID - 1327 AB - Objective: This study aims to compare food neophobia (FN) in groups of neurodivergent and neurotypical children with and without food restrictions. Methods: This cross-sectional study used a convenience sample of participants from all Brazilian Federative Units through the snowball method. Participants were separated into four groups for comparison: neurodivergent children without dietary restrictions; neurodivergent children with dietary restrictions; neurotypical children with dietary restrictions; and neurotypical children without dietary restrictions. The Brazilian Children's Food Neophobia Questionnaire (BCFNeo) was selected and administered to caregivers of Brazilian children between four and eleven years old. The categorization of FN scores followed a previously validated protocol. Results: The sample was composed of the caregivers of 2387 children. Considering the sample as a whole (neurodiversity), the prevalence of high FN was 44.2%. Boys are significantly more neophobic (p < 0.001) than girls. FN does not decrease with age. Older children (eight to eleven years) are equally neophobic as younger children (four to seven years). The prevalence of high FN was greater in neurodivergent children (without dietary restrictions-62.8% and with dietary restrictions-62.4%) than in neurotypical children (with dietary restrictions-29.4% and without dietary restrictions-33.4%). Conclusions: FN is more prevalent in boys and neurodivergent children, regardless of food restrictions and age. More longitudinal and experimental studies are necessary to evaluate the factors influencing FN in these groups and to develop intervention strategies. FAU - De Almeida, Priscila Claudino AU - De Almeida PC AUID- ORCID: 0000-0001-9871-0112 AD - Postgraduate Program in Human Nutrition, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Freire, Nathalia Franca AU - Freire NF AD - University of Brasilia, Brasilia 70910-900, Brazil. FAU - Oliveira, Leticia Leal de AU - Oliveira LL AD - University of Brasilia, Brasilia 70910-900, Brazil. FAU - Nakano, Eduardo Yoshio AU - Nakano EY AUID- ORCID: 0000-0002-9071-8512 AD - Department of Statistics, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Vasconcelos, Ivana Aragao Lira AU - Vasconcelos IAL AUID- ORCID: 0000-0001-6543-7690 AD - Department of Nutrition, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Zandonadi, Renata Puppin AU - Zandonadi RP AUID- ORCID: 0000-0003-0370-3089 AD - Department of Nutrition, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Botelho, Raquel Braz Assuncao AU - Botelho RBA AUID- ORCID: 0000-0002-0369-287X AD - Department of Nutrition, University of Brasilia, Brasilia 70910-900, Brazil. LA - eng GR - no number/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ GR - Edital n masculine 001/2025 DPI/BCE/UnB./Universidade de Brasilia/ PT - Comparative Study PT - Journal Article DEP - 20250411 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Brazil/epidemiology MH - Female MH - Male MH - Child MH - Cross-Sectional Studies MH - Child, Preschool MH - Surveys and Questionnaires MH - Prevalence MH - *Feeding Behavior/psychology MH - Food Preferences/psychology MH - *Diet/psychology PMC - PMC12030263 OTO - NOTNLM OT - caregiver perception OT - child OT - food neophobia OT - food restriction OT - neurodiversity COIS- The authors declare no conflicts of interest. EDAT- 2025/04/26 16:12 MHDA- 2025/04/26 16:45 PMCR- 2025/04/11 CRDT- 2025/04/26 01:16 PHST- 2025/03/18 00:00 [received] PHST- 2025/04/03 00:00 [revised] PHST- 2025/04/09 00:00 [accepted] PHST- 2025/04/26 16:45 [medline] PHST- 2025/04/26 16:12 [pubmed] PHST- 2025/04/26 01:16 [entrez] PHST- 2025/04/11 00:00 [pmc-release] AID - nu17081327 [pii] AID - nutrients-17-01327 [pii] AID - 10.3390/nu17081327 [doi] PST - epublish SO - Nutrients. 2025 Apr 11;17(8):1327. doi: 10.3390/nu17081327. PMID- 40284179 OWN - NLM STAT- MEDLINE DCOM- 20250426 LR - 20250428 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 8 DP - 2025 Apr 10 TI - Food Insecurity, Health, and Socioeconomic Status: Results from the University of the Basque Country, Spain. LID - 10.3390/nu17081314 [doi] LID - 1314 AB - Background/Objectives: Food insecurity (FI) is the 'limited or uncertain availability of nutritionally adequate and safe foods'. Although the literature suggests a strong association between FI, socioeconomic status (SES), and health, the nature of their relationship is not well specified in vulnerable population groups such as university students. To address this gap, this study aimed to assess the prevalence of FI among university students, examine its association with various health outcomes, and explore the potential mediating effect of SES. Methods: This cross-sectional survey included a convenience sample of 394 participants from the University of the Basque Country UPV/EHU (Spain). Data on SES, demographic and lifestyle factors, and health outcomes were collected between December 2021 and January 2022, using a questionnaire developed by the Food Insecurity among European University Students during the COVID-19 Pandemic (FINESCOP) consortium. Internal consistency of the questionnaire was assessed at the UPV/EHU using Cronbach's alpha. FI was measured using the Food Insecurity Experience Scale (FIES) from the FAO, which was validated through testing of Rasch model assumptions. Results: Overall, 19% of university students were food insecure, with 2.5% experiencing moderate and 0.8% experiencing severe FI. Adjusted linear regression models showed that FI was associated with a higher body mass index (BMI), poorer self-rated health, and worsening health during the pandemic. SES mediated the relationship between FI and health outcomes, with the strongest mediation observed for BMI (indirect association: B = 0.25, 95% CI = -0.17-0.75; total association: B = 1.85, 95% CI = 0.14-3.56; 15.3% of mediation). Conclusions: FI is prevalent among UPV/EHU students, and it is associated with multiple negative health outcomes, partly explained by SES. To effectively address FI, higher education institutions should consider implementing comprehensive strategies. For future research, longitudinal studies would be recommended to systematically monitor FI and examine causal relationships. FAU - Garcia-Iruretagoyena, Laura AU - Garcia-Iruretagoyena L AUID- ORCID: 0000-0002-8418-0410 AD - Department of Pharmacy and Food Sciences, University of the Basque Country UPV/EHU, 01006 Vitoria-Gasteiz, Spain. FAU - Martinez-Perez, Naiara AU - Martinez-Perez N AUID- ORCID: 0000-0001-7271-3657 AD - Department of Nursing I, University of the Basque Country UPV/EHU, 48940 Leioa, Spain. AD - BIOMICs Research Group, Microfluidics & BIOMICs Cluster, Lascaray Research Centre, University of the Basque Country UPV/EHU, 01006 Vitoria-Gasteiz, Spain. FAU - Colen, Liesbeth AU - Colen L AUID- ORCID: 0000-0003-1324-2570 AD - Department of Agricultural Economics and Rural Development, Faculty of Agricultural Sciences, University of Gottingen, 37073 Gottingen, Germany. FAU - Baeta, Miriam AU - Baeta M AD - BIOMICs Research Group, Microfluidics & BIOMICs Cluster, Lascaray Research Centre, University of the Basque Country UPV/EHU, 01006 Vitoria-Gasteiz, Spain. AD - Department of Zoology and Animal Cellular Biology, University of the Basque Country UPV/EHU, 01006 Vitoria-Gasteiz, Spain. AD - Bioaraba, BA04.03, 01006 Vitoria-Gasteiz, Spain. FAU - Olalde, Inigo AU - Olalde I AD - BIOMICs Research Group, Microfluidics & BIOMICs Cluster, Lascaray Research Centre, University of the Basque Country UPV/EHU, 01006 Vitoria-Gasteiz, Spain. AD - Bioaraba, BA04.03, 01006 Vitoria-Gasteiz, Spain. AD - Ikerbasque-Basque Foundation of Science, 48009 Bilbao, Spain. FAU - Torheim, Liv Elin AU - Torheim LE AUID- ORCID: 0000-0002-3161-1635 AD - Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University (OsloMet), 0130 Oslo, Norway. FAU - Arroyo-Izaga, Marta AU - Arroyo-Izaga M AUID- ORCID: 0000-0001-5592-4241 AD - Department of Pharmacy and Food Sciences, University of the Basque Country UPV/EHU, 01006 Vitoria-Gasteiz, Spain. AD - BIOMICs Research Group, Microfluidics & BIOMICs Cluster, Lascaray Research Centre, University of the Basque Country UPV/EHU, 01006 Vitoria-Gasteiz, Spain. AD - Bioaraba, BA04.03, 01006 Vitoria-Gasteiz, Spain. LA - eng GR - Campus Bizia Lab project: 21ARRO, 22ARRO, 23ARRO and 24ARRO/University of the Basque Country/ GR - IT1633-22/Basque Government/ PT - Journal Article DEP - 20250410 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Spain/epidemiology MH - *Food Insecurity MH - Female MH - Male MH - Cross-Sectional Studies MH - Universities MH - Young Adult MH - COVID-19/epidemiology MH - *Students/statistics & numerical data MH - Adult MH - *Social Class MH - *Health Status MH - Surveys and Questionnaires MH - Body Mass Index MH - SARS-CoV-2 MH - Adolescent MH - Prevalence MH - *Food Supply/statistics & numerical data PMC - PMC12030259 OTO - NOTNLM OT - food insecurity OT - health OT - higher education OT - mediation OT - socioeconomic status COIS- The authors declare no conflict of interest. EDAT- 2025/04/26 16:17 MHDA- 2025/04/26 16:18 PMCR- 2025/04/10 CRDT- 2025/04/26 01:16 PHST- 2025/03/18 00:00 [received] PHST- 2025/04/04 00:00 [revised] PHST- 2025/04/07 00:00 [accepted] PHST- 2025/04/26 16:18 [medline] PHST- 2025/04/26 16:17 [pubmed] PHST- 2025/04/26 01:16 [entrez] PHST- 2025/04/10 00:00 [pmc-release] AID - nu17081314 [pii] AID - nutrients-17-01314 [pii] AID - 10.3390/nu17081314 [doi] PST - epublish SO - Nutrients. 2025 Apr 10;17(8):1314. doi: 10.3390/nu17081314. PMID- 40283783 OWN - NLM STAT- MEDLINE DCOM- 20250426 LR - 20260924 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 22 IP - 4 DP - 2025 Apr 3 TI - Assessment of Sport and Physical Recreation Participation for Children and Youth with Disabilities: A Systematic Review. LID - 10.3390/ijerph22040557 [doi] LID - 557 AB - Accurate measurement of participation in sport/physical recreation for children with disabilities is important due to decreased physical activity in this population. This review examines the psychometric properties of relevant assessments. Four databases were searched for studies investigating assessments of participation in sport/physical recreation for children and youth with disabilities. The assessment content was analyzed by the proportion of items relevant to sport/physical recreation and the inclusion of participation elements (attendance or involvement). The evidence quality was evaluated using COnsensus-based Standards for the selection of health status Measurement Instruments (COSMIN) checklists and summarized according to Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Nine assessments (46 papers) met criteria. Only the Children's Assessment of Participation and Enjoyment measured attendance and involvement. Five assessments measured attendance (12-90% items related to sport/physical recreation) and three context-dependent assessments measured involvement. Only the Measure of Experiential Aspects of Participation and Self-reported Experiences of Activity Settings (involvement) were recommended by GRADE. No assessment adequately measured attendance and involvement in sport/physical recreation for children and youth with disabilities. While existing assessments may continue to be used to measure global participation, a comprehensive assessment of sport and physical recreation should be developed with and evaluated for children and youth with disabilities. FAU - Clutterbuck, Georgina Leigh AU - Clutterbuck GL AUID- ORCID: 0000-0002-8097-7836 AD - School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane 4072, Australia. FAU - Wen, Eugeenia AU - Wen E AUID- ORCID: 0009-0000-0577-6965 AD - School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane 4072, Australia. FAU - Petroccitto, Sara AU - Petroccitto S AUID- ORCID: 0009-0006-4004-5037 AD - School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane 4072, Australia. LA - eng PT - Journal Article PT - Systematic Review DEP - 20250403 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - Child MH - *Recreation MH - Adolescent MH - *Sports MH - *Children with Disabilities MH - *Exercise PMC - PMC12027276 OTO - NOTNLM OT - assessments OT - children OT - disability OT - outcome measure OT - participation OT - physical activity OT - physical recreation OT - psychometric OT - sport COIS- The authors declare no conflicts of interest. EDAT- 2025/04/26 16:16 MHDA- 2025/04/26 16:17 PMCR- 2025/04/03 CRDT- 2025/04/26 01:14 PHST- 2025/01/20 00:00 [received] PHST- 2025/03/24 00:00 [revised] PHST- 2025/03/29 00:00 [accepted] PHST- 2025/04/26 16:17 [medline] PHST- 2025/04/26 16:16 [pubmed] PHST- 2025/04/26 01:14 [entrez] PHST- 2025/04/03 00:00 [pmc-release] AID - ijerph22040557 [pii] AID - ijerph-22-00557 [pii] AID - 10.3390/ijerph22040557 [doi] PST - epublish SO - Int J Environ Res Public Health. 2025 Apr 3;22(4):557. doi: 10.3390/ijerph22040557. PMID- 40283657 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250428 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 14 IP - 8 DP - 2025 Apr 19 TI - The Hungarian Adaptation, Validity and Reliability of the Questionnaire "Health Questionnaire on Back Care Knowledge in Daily Life Physical Activities for Adolescent Students" Examining the Back Care Knowledge and Spine Disease Prevention. LID - 10.3390/jcm14082828 [doi] LID - 2828 AB - Background: There is a small number of questionnaires for children in the international literature that assess back care knowledge and spine disease prevention. A back care knowledge questionnaire in Hungarian for 14-17-year-old children is not yet available. This study aimed to translate and adapt the back care knowledge questionnaire published by Monfort et al. into the Hungarian language and to examine its reliability and validity in assessing the back care knowledge of 14-17-year-old children. Methods: This cross-sectional study included 253 (134 girls and 119 boys) adolescents, with a mean age of 14.84 (14-17) years. The questionnaire adaptation was performed according to Beaton's six-step principle. To test its internal consistency, the Kuder-Richardson 20 formula, containing binary variables, was used to assess the reliability of the questionnaire. The test-retest reliability was examined by the intraclass correlation coefficient (ICC). SPSS 27.0 software was used for data analysis, and the results were considered significant at p < 0.05. Results: The internal consistency measured by the Kuder-Richardson 20 coefficient examining the reliability of the questionnaire was 0.514. The test-retest reliability measured by intraclass correlation coefficients was 0.992 (0.985-0.996) p < 0.001. According to the Health Questionnaire on Back Care Knowledge and Spine Disease Prevention for 14-17-year-old children, the level of back care knowledge was 57.2%. Conclusions: The back care knowledge of Hungarian children is around 57.2%, which is lower than the data published in the international literature (60-70%). The Hungarian version of the questionnaire assessing the back care knowledge of 14-17-year-old children, the "Health Questionnaire on Back Care Knowledge and Spine Disease Prevention for 14-17 years old children (HEQBACK-14-17)", was found to be a suitable back care knowledge measuring tool among 14-17-year-olds; however, the development or adaptation of more measurement tools is needed for better understanding and more precise examination. FAU - Szilagyi, Brigitta AU - Szilagyi B AD - Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pecs, 7621 Pecs, Hungary. AD - Aurora Medical, 7624 Pecs, Hungary. FAU - Makai, Alexandra AU - Makai A AUID- ORCID: 0000-0002-1907-120X AD - Faculty of Health Sciences, University of Pecs, 7621 Pecs, Hungary. AD - Physical Activity Research Group, Szentagothai Research Centre, University of Pecs, 7622 Pecs, Hungary. FAU - Magyar, Borbala AU - Magyar B AD - Faculty of Health Sciences, University of Pecs, 7621 Pecs, Hungary. FAU - Gulyas-Tanacs, Nora AU - Gulyas-Tanacs N AD - Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pecs, 7621 Pecs, Hungary. FAU - Rebek-Nagy, Gabor AU - Rebek-Nagy G AD - Department of Languages for Biomedical Purposes and Communication, Medical School, University of Pecs, 7622 Pecs, Hungary. FAU - Gal-Kiss, Klaudia AU - Gal-Kiss K AD - Faculty of Health Sciences, University of Pecs, 7621 Pecs, Hungary. FAU - Tardi, Peter Sandor AU - Tardi PS AD - Faculty of Health Sciences, University of Pecs, 7621 Pecs, Hungary. FAU - Kovacs-Szabo, Zsofia AU - Kovacs-Szabo Z AUID- ORCID: 0000-0002-7075-126X AD - Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pecs, 7621 Pecs, Hungary. FAU - Jaromi, Melinda AU - Jaromi M AD - Faculty of Health Sciences, University of Pecs, 7621 Pecs, Hungary. FAU - Tumpek, Nikolett AU - Tumpek N AD - Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pecs, 7621 Pecs, Hungary. LA - eng PT - Journal Article DEP - 20250419 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC12028009 OTO - NOTNLM OT - back care knowledge and spine disease prevention OT - child OT - questionnaire OT - reliability OT - validity COIS- The authors declare no conflicts of interest. EDAT- 2025/04/26 16:09 MHDA- 2025/04/26 16:10 PMCR- 2025/04/19 CRDT- 2025/04/26 01:13 PHST- 2025/02/28 00:00 [received] PHST- 2025/04/12 00:00 [revised] PHST- 2025/04/15 00:00 [accepted] PHST- 2025/04/26 16:10 [medline] PHST- 2025/04/26 16:09 [pubmed] PHST- 2025/04/26 01:13 [entrez] PHST- 2025/04/19 00:00 [pmc-release] AID - jcm14082828 [pii] AID - jcm-14-02828 [pii] AID - 10.3390/jcm14082828 [doi] PST - epublish SO - J Clin Med. 2025 Apr 19;14(8):2828. doi: 10.3390/jcm14082828. PMID- 40283498 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250428 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 14 IP - 8 DP - 2025 Apr 14 TI - Influence of Dietary Habits on Macular Pigment in Childhood. LID - 10.3390/jcm14082668 [doi] LID - 2668 AB - Background/Objectives: To analyze the macular pigment optical density (MPOD) values in a child population and to evaluate the relation between MPOD and adherence to the Mediterranean diet using a validated questionnaire specially created for children. Eighty-eight children were included in this cross-sectional study from two primary education schools of Seville (Spain). Methods: MPOD values were measured using Macular Pigment Screener II ((R)). Lutein and Zeaxanthin intake was evaluated by KIDMED questionnaire, which classifies children according to adherence to the Mediterranean diet. A whole ocular exam with slit-lamp biomicroscopy was conducted by a specialized optometrist. Results: The mean age ranged between 6 and 8 years. The mean MPOD value was 0.46 +/- 0.18. The mean score of the KIDMED questionnaire was 7.19 +/- 1.85. No statistically significant differences were found as a function of gender or among Mediterranean diet adherence groups. No significant differences in MPOD values between answers were found in any KIDMED questions. No correlations were found for MPOD with several variables, such as Mediterranean diet adherence and KIDMED score. Conclusions: MPOD levels in children could not be correlated with Mediterranean Diet adherence and, thus, good dietary habits. Genetic characteristics, mother's diet habits, oxidative stress, and body fat composition in children could be the main factors influencing MPOD levels. FAU - Ponce-Garcia, Victor AU - Ponce-Garcia V AUID- ORCID: 0009-0007-6308-6920 AD - Vision Research Group (CIVIUS), Department of Physics of Condensed Matter, Optics Area, University of Seville, 41012 Seville, Spain. FAU - Bautista-Llamas, Maria-Jose AU - Bautista-Llamas MJ AUID- ORCID: 0000-0001-8317-5014 AD - Vision Research Group (CIVIUS), Department of Physics of Condensed Matter, Optics Area, University of Seville, 41012 Seville, Spain. FAU - Garcia-Romera, Marta-C AU - Garcia-Romera MC AUID- ORCID: 0000-0002-8476-0642 AD - Vision Research Group (CIVIUS), Department of Physics of Condensed Matter, Optics Area, University of Seville, 41012 Seville, Spain. LA - eng PT - Journal Article DEP - 20250414 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC12027799 OTO - NOTNLM OT - Mediterranean diet OT - children OT - lutein OT - macular carotenoids OT - macular pigment OT - zeaxanthin COIS- The authors declare no conflicts of interest. EDAT- 2025/04/26 16:05 MHDA- 2025/04/26 16:06 PMCR- 2025/04/14 CRDT- 2025/04/26 01:12 PHST- 2025/01/27 00:00 [received] PHST- 2025/03/27 00:00 [revised] PHST- 2025/04/11 00:00 [accepted] PHST- 2025/04/26 16:06 [medline] PHST- 2025/04/26 16:05 [pubmed] PHST- 2025/04/26 01:12 [entrez] PHST- 2025/04/14 00:00 [pmc-release] AID - jcm14082668 [pii] AID - jcm-14-02668 [pii] AID - 10.3390/jcm14082668 [doi] PST - epublish SO - J Clin Med. 2025 Apr 14;14(8):2668. doi: 10.3390/jcm14082668. PMID- 40280983 OWN - NLM STAT- MEDLINE DCOM- 20250426 LR - 20250507 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Apr 25 TI - A prediction model for moderate to severe pain in primary hepatic carcinoma after chemotherapy: a multi-center prospective case‒control study. PG - 14415 LID - 10.1038/s41598-025-90814-6 [doi] LID - 14415 AB - The incidence of moderate to severe pain after chemotherapy with primary hepatic carcinoma (PHC) patients is high. Although standardized treatment can effectively relieve pain, the control effect is poor. More attention should be paid to the prevention of pain at the beginning of symptoms, so as to reduce the incidence of pain and promote the health of patients. However, there are lack of a prospective design to predict pain before it occurs. The study is a prospective case‒control study. Population was PHC patients who received chemotherapy from April to August to 2024 in three grade 3 and first-class hospital. Data were collected in two periods (on the day of admission and within 24 h of chemotherapy). According to the Brief Pain Inventory, the patients were divided into case group and control group. Then the patients were randomly divided into a training group and an internal validation group at a 2:1 ratio. Single-factor logistics regression was used to analyze the risk factors, and the back-propagation artificial neural network (BP-ANN) model was constructed and verified. A total of 467 patients consisting of 312 training samples and 155 validation samples. BP-ANN model showed the AUC, sensitivity, specificity, and accuracy of prediction were 0.808, 70.6%, 81.7%, 93%, respectively. Internal verification also indicated these indicators were 0.783, 78.8%, 70.8%, and 94.2%, respectively. Significant predictors identified were age > 57.5, BMI > 19.9, symptoms of insomnia prior to illness, worker, Renvastinib, Child-Pugh = B, glutamic oxalacetic transaminase, other platinum drugs, cancer staging of IV, ECOG = 2, NRS-2002 = 3, Oxaliplatin, and Donafenib. The BP-ANN model holds high predictive value for the moderate to severe pain of PHC patients after chemotherapy. In the future, the model can be further visualized to facilitate clinical screening and to provide a basis for subsequent intervention. CI - (c) 2025. The Author(s). FAU - Huang, Siting AU - Huang S AD - Department of Nursing, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350122, Fujian Province, China. FAU - Liu, Aiqin AU - Liu A AD - Department of Nursing, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350122, Fujian Province, China. FAU - Yu, Xiaoruo AU - Yu X AD - Department of Nursing, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian Province, China. FAU - Qiu, Zhifeng AU - Qiu Z AD - Department of Nursing, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350122, Fujian Province, China. FAU - Weng, Guizhen AU - Weng G AD - Department of Oncology Nursing, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China. FAU - Liu, Dun AU - Liu D AD - The School of Nursing, Fujian Medical University, Fuzhou, Fujian Province, China. FAU - Wang, Yan AU - Wang Y AD - Department of Nursing, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350122, Fujian Province, China. FAU - Zhuo, Yan AU - Zhuo Y AD - Department of Nursing, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350122, Fujian Province, China. FAU - Yao, Liuqing AU - Yao L AD - Department of Nursing, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350122, Fujian Province, China. FAU - Yang, Mei AU - Yang M AD - Department of Nursing, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350122, Fujian Province, China. FAU - Lin, Hui AU - Lin H AD - Department of Nursing, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350122, Fujian Province, China. 284327560@qq.com. FAU - Ke, Xi AU - Ke X AD - Department of Nursing, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350122, Fujian Province, China. cijuna147a@163.com. LA - eng GR - 2024J011104/Natural Science Foundation of Fujian Province/ PT - Journal Article PT - Multicenter Study DEP - 20250425 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Antineoplastic Agents) SB - IM MH - Humans MH - Male MH - Female MH - Middle Aged MH - Case-Control Studies MH - *Liver Neoplasms/drug therapy/complications MH - Prospective Studies MH - Aged MH - *Carcinoma, Hepatocellular/drug therapy/complications MH - Risk Factors MH - Adult MH - Neural Networks, Computer MH - *Pain/etiology MH - *Antineoplastic Agents/adverse effects/therapeutic use PMC - PMC12032026 OTO - NOTNLM OT - Back-propagation artificial neural networks OT - Cancer-related pain OT - Primary hepatic carcinoma OT - Risk factors COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Hospital (K2023-408-1). All methods adhered to relevant ethical guidelines and regulations, and no participant could be identified from the data. The studies were conducted in accordance with the local legislation and institutional requirements. Informed consent was obtained from all subjects and/or their legal guardians. EDAT- 2025/04/26 16:04 MHDA- 2025/04/26 16:44 PMCR- 2025/04/25 CRDT- 2025/04/25 23:17 PHST- 2024/11/09 00:00 [received] PHST- 2025/02/17 00:00 [accepted] PHST- 2025/04/26 16:44 [medline] PHST- 2025/04/26 16:04 [pubmed] PHST- 2025/04/25 23:17 [entrez] PHST- 2025/04/25 00:00 [pmc-release] AID - 10.1038/s41598-025-90814-6 [pii] AID - 90814 [pii] AID - 10.1038/s41598-025-90814-6 [doi] PST - epublish SO - Sci Rep. 2025 Apr 25;15(1):14415. doi: 10.1038/s41598-025-90814-6. PMID- 40280169 OWN - NLM STAT- MEDLINE DCOM- 20260128 LR - 20260129 IS - 1438-9010 (Electronic) IS - 1438-9010 (Linking) VI - 198 IP - 2 DP - 2026 Feb TI - Equal image quality and reduced radiation exposure in whole-spine X-ray imaging with slot-scanning technique compared with stitched radiography. PG - 219-227 LID - 10.1055/a-2564-0580 [doi] AB - Repeated whole-spine imaging in children and adolescents with scoliosis causes significant cumulative radiation exposure. Low-dose slot-scanning imaging can reduce radiation exposure. The aim of this study was to compare whole-spine imaging using the slot-scanning technique (SST) with conventional stitched radiography (SR) with regard to image quality and radiation dose.We recruited 30 patients with a clinical indication for whole-spine imaging by SST, who had prior whole-spine imaging by SR available. 41 images acquired using both techniques were analyzed. The dose area product (DAP) and patient age, weight, height, and body-mass index were recorded. Image quality was assessed for 28 anatomical landmarks on a 4-point Likert scale by 4 raters. Group-wise comparisons were performed using paired t-tests. Interrater rating reliability was assessed using the interrater correlation coefficient.The mean DAP was significantly lower for SST than for SR (SST 8.0 +/- 5.7 cGy . cm(2), SR 32.5 +/- 34.5 cGy . cm(2), p < 0.001). The image quality was rated good for both modalities (means: SST 2.8 +/- 0.6, SR 2.7 +/- 0.5, p = 0.38). There was no significant difference in image quality ratings between both modalities. The inter-rater reliability was excellent with an inter-rater correlation coefficient of 0.86. Orthopedic surgeons rated the image quality of SST significantly better than that of SR.This study shows a significant reduction in radiation exposure for slot-scanning whole-spine imaging compared to stitched radiography with equal image quality, which facilitates the reduction of radiation exposure for repeated whole-spine imaging in children and adolescents to 25%. . Image quality is comparable between slot-scanning and stitched whole-spine imaging.. . The slot-scanning technique had a significantly lower dose area product compared with stitched radiographs.. . Orthopedic surgeons rated the image quality of slot-scanning significantly better than that of stitching.. . Radiation exposure in scoliosis whole-spine imaging can be reduced to 25%.. . Liebscher H, Scherzer M, Meissner C et al. Equal image quality and reduced radiation exposure in whole-spine X-ray imaging with slot-scanning technique compared with stitched radiography. Rofo 2026; 198: 219-227. CI - Thieme. All rights reserved. FAU - Liebscher, Hendrik AU - Liebscher H AD - Institute and Polyclinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus at the Technische Universitat Dresden, Dresden, Germany. FAU - Scherzer, Mechthild AU - Scherzer M AD - Institute and Polyclinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus at the Technische Universitat Dresden, Dresden, Germany. FAU - Meissner, Christoph AU - Meissner C AD - Institute and Polyclinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus at the Technische Universitat Dresden, Dresden, Germany. FAU - Zwingenberger, Stefan AU - Zwingenberger S AD - University Centre for Orthopaedics, Traumatology and Plastic Surgery, University Hospital Carl Gustav Carus at the Technische Universitat Dresden, Dresden, Germany. FAU - Platz, Uwe AU - Platz U AD - University Centre for Orthopaedics, Traumatology and Plastic Surgery, University Hospital Carl Gustav Carus at the Technische Universitat Dresden, Dresden, Germany. FAU - Hahlbohm, Patricia AU - Hahlbohm P AD - Institute and Polyclinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus at the Technische Universitat Dresden, Dresden, Germany. FAU - Schon, Felix AU - Schon F AD - Institute and Polyclinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus at the Technische Universitat Dresden, Dresden, Germany. FAU - Kuhn, Jens-Peter AU - Kuhn JP AD - Institute and Polyclinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus at the Technische Universitat Dresden, Dresden, Germany. FAU - Hoffmann, Ralf-Thorsten AU - Hoffmann RT AD - Institute and Polyclinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus at the Technische Universitat Dresden, Dresden, Germany. FAU - Blum, Sophia Freya Ulrike AU - Blum SFU AUID- ORCID: 0000-0001-7096-5199 AD - Institute and Polyclinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus at the Technische Universitat Dresden, Dresden, Germany. LA - eng PT - Comparative Study PT - Journal Article TT - Gleichwertige Bildqualitat und reduzierte Strahlenexposition bei Rontgenaufnahmen der ganzen Wirbelsaule mit Slot-Scanning-Technik im Vergleich zur Stitching-Technik. DEP - 20250425 PL - Germany TA - Rofo JT - RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin JID - 7507497 SB - IM MH - Humans MH - Adolescent MH - Child MH - Male MH - *Scoliosis/diagnostic imaging MH - Female MH - *Radiation Dosage MH - *Spine/diagnostic imaging MH - *Radiation Exposure/prevention & control MH - *Radiography/methods MH - Reproducibility of Results COIS- SFUB has received lecture fees from Siemens Healthineers. UP has received payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Stryker and support for attending meetings and/or travel from Stryker, Medtronic, Nuvasive, Globus Medical. EDAT- 2025/04/26 16:05 MHDA- 2026/01/29 01:47 CRDT- 2025/04/25 19:23 PHST- 2026/01/29 01:47 [medline] PHST- 2025/04/26 16:05 [pubmed] PHST- 2025/04/25 19:23 [entrez] AID - 10.1055/a-2564-0580 [doi] PST - ppublish SO - Rofo. 2026 Feb;198(2):219-227. doi: 10.1055/a-2564-0580. Epub 2025 Apr 25. PMID- 40279700 OWN - NLM STAT- MEDLINE DCOM- 20250511 LR - 20260820 IS - 1873-2054 (Electronic) IS - 1353-8292 (Linking) VI - 93 DP - 2025 May TI - Neighbourhood, school and home food environment associations with dietary behaviours in Hong Kong adolescents: the iHealth study. PG - 103472 LID - S1353-8292(25)00062-0 [pii] LID - 10.1016/j.healthplace.2025.103472 [doi] AB - This study is the first to examine whether neighbourhood, school and home food environments were associated with dietary behaviours in Hong Kong adolescents; and whether off-campus lunch school policy, bringing lunch from home and parental rules for eating behaviours moderated the associations. We used data from the international Healthy environments and active living in teenagers - (Hong Kong) [iHealt(H)] study. Participants were healthy adolescents aged 11-18 years (N = 1299; M(age) = 14.7 years; 57 % girls) and their parent/primary caregivers. Participants completed surveys with validated scales to assess dietary behaviours and perceived food environments. The Microscale Audit of Pedestrian Streetscapes and Geographic Information Systems data and software were used to objectively assess food environments. A higher number of bakeries, coffee shops, cafes and convenience stores in the neighbourhood was associated with higher consumption of vegetables and lower consumption of sugar-sweetened drinks in adolescents. Adolescents who frequently brought lunch from home to school consumed fatty foods and sugar-sweetened drinks less frequently and were more likely to eat fruits and vegetables. Greater availability of unhealthy food outlets at the school was associated with higher consumption of sugar-sweetened drinks, whereas more restaurants around the school was associated with higher consumption of fruits and vegetables. Home-made lunches and restrictive parental eating rules moderated the effects of food environments on adolescents' dietary behaviours. All food environmental contexts were associated with Hong Kong adolescents' dietary behaviours; however, the home and school environment appeared to be the most influential and should be targeted in public health interventions. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Soloveva, Maria V AU - Soloveva MV AD - Mary MacKillop Institute for Health Research, Australian Catholic University, Australia. Electronic address: Maria.Soloveva@acu.edu.au. FAU - Barnett, Anthony AU - Barnett A AD - Mary MacKillop Institute for Health Research, Australian Catholic University, Australia. FAU - Mellecker, Robin AU - Mellecker R AD - Faculty of Education, The University of Hong Kong, Hong Kong, China. FAU - Sit, Cindy AU - Sit C AD - Department of Sports Science and Physical Education, The Chinese University of Hong Kong, Hong Kong, China. FAU - Lai, Poh-Chin AU - Lai PC AD - Department of Geography, Faculty of Social Sciences, The University of Hong Kong, Hong Kong, China. FAU - Zhang, Casper J P AU - Zhang CJP AD - School of Public Health, The University of Hong Kong, Hong Kong, China. FAU - Sallis, James F AU - Sallis JF AD - Mary MacKillop Institute for Health Research, Australian Catholic University, Australia; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA. FAU - Cerin, Ester AU - Cerin E AD - Mary MacKillop Institute for Health Research, Australian Catholic University, Australia; School of Public Health, The University of Hong Kong, Hong Kong, China; Baker Heart and Diabetes Institute, Melbourne, Australia; Department of Community Medicine, UiT the Arctic University of Norway, Tromso, Norway. LA - eng GR - R01 HL111378/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20250424 PL - England TA - Health Place JT - Health & place JID - 9510067 SB - IM MH - Humans MH - Adolescent MH - Hong Kong MH - Female MH - Male MH - *Schools MH - *Residence Characteristics/statistics & numerical data MH - Child MH - *Feeding Behavior MH - *Diet MH - *Home Environment MH - Surveys and Questionnaires MH - Vegetables OTO - NOTNLM OT - Adolescents dietary behaviours OT - Food environments OT - Home-made lunch OT - Off-campus lunch school policy OT - Parental eating rules COIS- Declaration of competing interests The authors declare that they have no competing interests. EDAT- 2025/04/26 16:07 MHDA- 2025/05/11 19:57 CRDT- 2025/04/25 18:03 PHST- 2024/12/15 00:00 [received] PHST- 2025/03/17 00:00 [revised] PHST- 2025/04/17 00:00 [accepted] PHST- 2025/05/11 19:57 [medline] PHST- 2025/04/26 16:07 [pubmed] PHST- 2025/04/25 18:03 [entrez] AID - S1353-8292(25)00062-0 [pii] AID - 10.1016/j.healthplace.2025.103472 [doi] PST - ppublish SO - Health Place. 2025 May;93:103472. doi: 10.1016/j.healthplace.2025.103472. Epub 2025 Apr 24. PMID- 40279302 OWN - NLM STAT- MEDLINE DCOM- 20250425 LR - 20260930 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 4 DP - 2025 TI - The Turkish validity and reliability of the Reward-Based Eating Drive (RED-13) Scale. PG - e0322097 LID - 10.1371/journal.pone.0322097 [doi] LID - e0322097 AB - The study was registered on ClinicalTrials.gov (number: NCT05017506). CI - Copyright: (c) 2025 Yilmaz Yavuz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Yilmaz Yavuz, Ayten AU - Yilmaz Yavuz A AUID- ORCID: 0000-0002-5861-4254 AD - Department of Public Health Nursing, Faculty of Health Science, Recep Tayyip Erdogan University, Rize, Turkey. FAU - Altinsoy, Canan AU - Altinsoy C AD - Department of Nutrition and Dietetics, Faculty of Health Science, Recep Tayyip Erdogan University, Rize, Turkey. FAU - Toraman, Merve Nur AU - Toraman MN AD - Training and Research Hospital, Recep Tayyip Erdogan University, Rize, Turkey. FAU - Karabulut Musdal, Nazan AU - Karabulut Musdal N AD - Training and Research Hospital, Recep Tayyip Erdogan University, Rize, Turkey. LA - eng SI - ClinicalTrials.gov/NCT05017506 PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20250425 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM EIN - PLoS One. 2025 Oct 6;20(10):e0333804. doi: 10.1371/journal.pone.0333804. PMID: 41052014 MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Young Adult MH - *Eating/psychology MH - *Feeding Behavior/psychology MH - Reproducibility of Results MH - *Reward MH - Surveys and Questionnaires MH - Turkey PMC - PMC12026936 COIS- The authors have declared that no competing interests exist. EDAT- 2025/04/25 18:33 MHDA- 2025/04/25 18:34 PMCR- 2025/04/25 CRDT- 2025/04/25 13:23 PHST- 2024/12/18 00:00 [received] PHST- 2025/03/17 00:00 [accepted] PHST- 2025/04/25 18:34 [medline] PHST- 2025/04/25 18:33 [pubmed] PHST- 2025/04/25 13:23 [entrez] PHST- 2025/04/25 00:00 [pmc-release] AID - PONE-D-24-55287 [pii] AID - 10.1371/journal.pone.0322097 [doi] PST - epublish SO - PLoS One. 2025 Apr 25;20(4):e0322097. doi: 10.1371/journal.pone.0322097. eCollection 2025. PMID- 40278602 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250427 IS - 2305-6304 (Electronic) IS - 2305-6304 (Linking) VI - 13 IP - 4 DP - 2025 Apr 8 TI - Exploring the Association Between Sleep Patterns, Pubertal Health, and Phthalate Exposure-Preliminary Results from Slovakia. LID - 10.3390/toxics13040286 [doi] LID - 286 AB - BACKGROUND: This study aims to explore the association between sleep patterns in children and their exposure to phthalates to assess potential health implications. METHODS: Participants (n = 60) completed the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Consumer behavior scores (CBS) were calculated. The Tanner scale was used to monitor the stages of puberty. First-morning urine samples were analyzed by high-performance liquid chromatography-tandem mass spectrometry. RESULTS: The average sleep duration was 8 h and 44 min, with boys sleeping significantly longer (p = 0.01). Notably, 51.7% of participants reported sleeping less than 9 h. The nonlinear effects of phthalate metabolite in association with PSQI were observed for hydroxy-mono-isononyl phthalate (OH-MiNP, p = 0.003) and MnOP (p < 0.001), indicating that the relationship does not follow a simple linear pattern. Simple linear regression revealed a significant positive association between the Mono-n-octyl phthalate (MnOP) and PSQI scores (p = 0.016). After adjustment for place of residence, BMI, CBS, sex, and age, the significance of associations between phthalate metabolites and sleep quality diminished, necessitating cautious interpretation. No statistically significant associations between pubertal changes and the value of PSQI as well as phthalates were observed. CONCLUSION: Our results provide preliminary evidence of potential nonlinear associations that require validation in a larger cohort. The findings highlight the importance of monitoring phthalate exposure in children, as it may influence sleep patterns and overall health. FAU - Jahnatkova, Martina AU - Jahnatkova M AD - Department of Zoology and Anthropology, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia. FAU - Hlisnikova, Henrieta AU - Hlisnikova H AD - Institute of Environmental Medicine, Karolinska Institutet, Nobels Vag 13, 171 77 Stockholm, Sweden. FAU - Petrovicova, Ida AU - Petrovicova I AUID- ORCID: 0000-0003-0485-9392 AD - Department of Zoology and Anthropology, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia. FAU - Kolena, Branislav AU - Kolena B AUID- ORCID: 0000-0003-1524-1512 AD - Department of Zoology and Anthropology, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia. LA - eng PT - Journal Article DEP - 20250408 PL - Switzerland TA - Toxics JT - Toxics JID - 101639637 PMC - PMC12031374 OTO - NOTNLM OT - biomonitoring OT - endocrine disruptors OT - phthalates OT - puberty OT - sleep quality COIS- The authors declare no conflicts of interest. EDAT- 2025/04/25 13:47 MHDA- 2025/04/25 13:48 PMCR- 2025/04/08 CRDT- 2025/04/25 10:23 PHST- 2025/01/29 00:00 [received] PHST- 2025/03/11 00:00 [revised] PHST- 2025/04/04 00:00 [accepted] PHST- 2025/04/25 13:48 [medline] PHST- 2025/04/25 13:47 [pubmed] PHST- 2025/04/25 10:23 [entrez] PHST- 2025/04/08 00:00 [pmc-release] AID - toxics13040286 [pii] AID - toxics-13-00286 [pii] AID - 10.3390/toxics13040286 [doi] PST - epublish SO - Toxics. 2025 Apr 8;13(4):286. doi: 10.3390/toxics13040286. PMID- 40273815 OWN - NLM STAT- MEDLINE DCOM- 20250524 LR - 20250627 IS - 1873-2364 (Electronic) IS - 0960-8966 (Linking) VI - 50 DP - 2025 May TI - 280th ENMC International Workshop: The ERN EURO-NMD mitochondrial diseases working group; diagnostic criteria and outcome measures in primary mitochondrial myopathies. Hoofddorp, the Netherlands, 22-24 November 2024. PG - 105340 LID - S0960-8966(25)00067-7 [pii] LID - 10.1016/j.nmd.2025.105340 [doi] AB - The 280th ENMC International Workshop, held in Hoofddorp, The Netherlands, November 22-24, 2024, focused on primary mitochondrial myopathies (PMM). The workshop aimed to update diagnostic criteria, outcome measures, and explore new digital health technologies (DHTs) in the context of clinical trial design and conduct for PMM. Key points discussed included: (i) PMM definition and phenotypes; PMM are genetically determined mitochondrial disorders with prominent skeletal muscle involvement with two major phenotypes: mitochondrial myopathy (MiMy) either with or without chronic progressive external ophthalmoplegia (PEO); (ii) diagnostic criteria, with emphasis on the importance of genetic testing and muscle biopsy for accurate diagnosis; (iii) outcome measures: consensus on clinical scales, functional tests, performance measures, and patient-reported outcome measures (PROMs) for both adults and children; (iv) digital health technologies, with exploration of wearable and non-wearable technologies for gait analysis, physical activity monitoring, and other assessments; (v) potential and limitations of biomarkers for PMM diagnosis and monitoring. The workshop concluded with a strong consensus on the updated definition of PMM, its phenotypes, and the recommended outcome measures for clinical studies. Further research is needed to validate digital health technologies and biomarkers for PMM. CI - Copyright (c) 2025 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Mancuso, Michelangelo AU - Mancuso M AD - Department of Clinical and Experimental Medicine, Neurological Institute, University of Pisa, Pisa, Italy. Electronic address: michelangelo.mancuso@unipi.it. FAU - Lopriore, Piervito AU - Lopriore P AD - Department of Clinical and Experimental Medicine, Neurological Institute, University of Pisa, Pisa, Italy; PhD School in Translational Medicine, Scuola Superiore Sant'Anna, Pisa, Italy. FAU - Semmler, Luisa AU - Semmler L AD - Department of Neurology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany. FAU - Kornblum, Cornelia AU - Kornblum C AD - Department of Neuromuscular Diseases, Center for Neurology, University Hospital Bonn, Germany. CN - 280th ENMC workshop study group LA - eng PT - Journal Article DEP - 20250322 PL - England TA - Neuromuscul Disord JT - Neuromuscular disorders : NMD JID - 9111470 SB - IM MH - Humans MH - *Mitochondrial Myopathies/diagnosis/therapy/genetics MH - Netherlands MH - *Outcome Assessment, Health Care MH - Patient Reported Outcome Measures OTO - NOTNLM OT - Biomarkers OT - Clinical trials OT - Diagnostic criteria OT - Outcome measures OT - Primary mitochondrial myopathy COIS- Declaration of competing interest Michelangelo Mancuso, Piervito Lopriore, Luisa Semmler and Cornelia Kornblum have nothing to disclose related to this publication FIR - Artuch, Rafael IR - Artuch R IRAD- Biomedical Network Research Centre on Rare Diseases (CIBERER), Instituto de Salud Carlos III and Hospital Sant Joan de Deu, Barcelona, Spain. FIR - Bellusci, Marcello IR - Bellusci M IRAD- Reference Center for Inherited Metabolic Disorders MetabERN, Mitochondrial Disorders Research Group (imas12), '12 de Octubre' University Hospital, Madrid, Spain. FIR - Bertini, Enrico IR - Bertini E IRAD- Bambino Gesu Hospital IRCCS, Rome, Italy. FIR - Carelli, Valerio IR - Carelli V IRAD- IRCCS Istituto delle Scienze Neurologiche di Bologna, Bellaria Hospital and Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy; Patrick Chinnery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. FIR - Distelmaier, Felix IR - Distelmaier F IRAD- University Children's Hospital, Dusseldorf, Germany. FIR - Hirano, Michio IR - Hirano M IRAD- Columbia University Irving Medical Center, New York, USA. FIR - Horvath, Rita IR - Horvath R IRAD- Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. FIR - Janssen, Mirian Ch IR - Janssen MC IRAD- Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands. FIR - Karaa, Amel IR - Karaa A IRAD- Mass General Hospital/Harvard Medical School, Boston USA. FIR - Klopstock, Thomas IR - Klopstock T IRAD- Department of Neurology, Friedrich-Baur-Institute, LMU University Hospital, Ludwig-Maximilians-Universitat Munchen, Munich; German Center for Neurodegenerative Diseases (DZNE); Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. FIR - Kornblum, Cornelia IR - Kornblum C IRAD- Department of Neuromuscular Diseases, Center for NeurologyUniversity Hospital Bonn, Bonn, Germany. FIR - Lamperti, Costanza IR - Lamperti C IRAD- Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy. FIR - Lopriore, Piervito IR - Lopriore P IRAD- University of Pisa, Italy. FIR - McFarland, Robert IR - McFarland R IRAD- Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK; NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. FIR - Ng, Yi Shiau IR - Ng YS IRAD- Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK; NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. FIR - Mancuso, Michelangelo IR - Mancuso M IRAD- University of Pisa, Italy. FIR - Prokisch, Holger IR - Prokisch H IRAD- School of Medicine, Technical University of Munich, Munich, Germany; German Center for Child and Adolescent Health (DZKJ), partner site Munich, Munich, Germany; Institute of Neurogenomics, Computational Health Centre, Helmholtz Zentrum Munchen, Neuherberg, Germany. FIR - Rahman, Shamima IR - Rahman S IRAD- UCL Great Ormond Street Institute of Child Health, London, UK. FIR - Schiff, Manuel IR - Schiff M IRAD- Reference Center for Mitochondrial Disorders (CARAMMEL) and Reference Center for Inborn Errors of Metabolism, Department of Pediatrics, Necker-Enfants-Malades Hospital, Assistance Publique-Hopitaux de Paris, University of Paris-Cite, MetabERN, Paris; 22INSERM UMRS_1163, Imagine Institute, Paris, France. FIR - Semmler, Luisa IR - Semmler L IRAD- Department of Neurology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany. FIR - Serenella, Servidei IR - Serenella S IRAD- Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli IRCCS; Dipartimento Di Neuroscienze, Universita Cattolica del Sacro Cuore, Rome, Italy. FIR - Taivassalo, Tanja IR - Taivassalo T IRAD- Department of Physiology and Aging, Clinical Translational Research Building, University of Florida, 2004 Mowry Road, Gainesville, FL, USA. FIR - Vissing, John IR - Vissing J IRAD- Copenhagen Neuromuscular Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. FIR - van den Ameele, Jelle IR - van den Ameele J IRAD- Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. FIR - Waller, Katie IR - Waller K IRAD- Lily Foundation, UK. EDAT- 2025/04/25 01:21 MHDA- 2025/05/25 20:35 CRDT- 2025/04/24 18:11 PHST- 2025/03/05 00:00 [received] PHST- 2025/03/10 00:00 [accepted] PHST- 2025/05/25 20:35 [medline] PHST- 2025/04/25 01:21 [pubmed] PHST- 2025/04/24 18:11 [entrez] AID - S0960-8966(25)00067-7 [pii] AID - 10.1016/j.nmd.2025.105340 [doi] PST - ppublish SO - Neuromuscul Disord. 2025 May;50:105340. doi: 10.1016/j.nmd.2025.105340. Epub 2025 Mar 22. PMID- 40273569 OWN - NLM STAT- MEDLINE DCOM- 20250530 LR - 20260925 IS - 1873-7358 (Electronic) IS - 1471-0153 (Print) IS - 1471-0153 (Linking) VI - 57 DP - 2025 Apr TI - A formative study of grandparent caregivers' grandchild feeding responsibilities and practices. PG - 101982 LID - S1471-0153(25)00042-X [pii] LID - 10.1016/j.eatbeh.2025.101982 [doi] AB - BACKGROUND: In the US, grandparents are increasingly living with their grandchildren in multigenerational households and/or providing their grandchildren with regular childcare. However, our understanding of the potential for these grandparents to influence children's nutrition and weight status is limited. This formative study aimed to 1) describe the scope of caregiving grandparents' grandchild-focused food responsibilities and practices, including agreement and discordance with parents' food parenting practices, and 2) assess the internal reliability and acceptability of an adapted CFPQ to measure grandparents' food parenting practices. METHODS: Thirty-two grandparents residing with and/or providing regular childcare for their 3 to 5-year-old grandchild enrolled. Data from interviews and closed-ended survey questions were analyzed to identify prevalent food-related responsibilities and practices. Grandparents also completed an adapted version of the CFPQ and provided feedback on applicability and face validity. RESULTS: Over 80 % of grandparents were at least "sometimes" responsible for planning, preparing, and serving meals and snacks to their grandchild. Cooking, baking, and eating together were common. While many grandparents reported agreeing with their grandchild's parents' food parenting practices, others felt parents were either too lax or too strict. Only 5 of 12 subscales of the CFPQ demonstrated strong internal reliability when used with grandparents; some grandparents reported difficulty completing the CFPQ as they were not with the grandchildren for all eating occasions, and their feeding practices varied over time. CONCLUSION: Many caregiving grandparents have significant responsibility for their grandchildren's nutrition environments. Identifying how grandparents' food responsibilities and practices influence children's nutrition and weight status, independently and in conjunction with parents' practices, is a high priority. Grandparent-specific measures of food parenting are needed to advance this research. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - Varela, Elder Garcia AU - Varela EG AD - Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, United States of America. Electronic address: egvarela@umich.edu. FAU - Clayson, Michelle E AU - Clayson ME AD - Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, United States of America. FAU - Weeks, Heidi M AU - Weeks HM AD - Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, United States of America. FAU - Ramos, Carmen AU - Ramos C AD - Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, United States of America. FAU - Birditt, Kira S AU - Birditt KS AD - Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, United States of America. FAU - Laska, Melissa N AU - Laska MN AD - Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, United States of America. FAU - Haines, Jess AU - Haines J AD - Department of Family Relations & Applied Nutrition, University of Guelph, Guelph, ON, Canada. FAU - Miller, Alison L AU - Miller AL AD - Department of Health Behavior and Equity, School of Public Health, University of Michigan, Ann Arbor, MI, United States of America. FAU - Bauer, Katherine W AU - Bauer KW AD - Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, United States of America. LA - eng GR - R01 HL150848/HL/NHLBI NIH HHS/United States GR - UL1 TR002240/TR/NCATS NIH HHS/United States GR - UM1 TR004404/TR/NCATS NIH HHS/United States PT - Journal Article DEP - 20250421 PL - United States TA - Eat Behav JT - Eating behaviors JID - 101090048 SB - IM MH - Humans MH - *Grandparents/psychology MH - Male MH - Female MH - Child, Preschool MH - *Parenting/psychology MH - Middle Aged MH - *Feeding Behavior/psychology MH - *Caregivers/psychology MH - Adult MH - Aged MH - Surveys and Questionnaires MH - *Intergenerational Relations MH - Child Rearing MH - Reproducibility of Results PMC - PMC12291788 MID - NIHMS2077730 OTO - NOTNLM OT - Caregivers OT - Early childhood OT - Feeding practices OT - Feeding responsibilities OT - Grandparents COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article. EDAT- 2025/04/25 01:21 MHDA- 2025/05/31 00:36 PMCR- 2026/04/21 CRDT- 2025/04/24 18:05 PHST- 2024/10/02 00:00 [received] PHST- 2025/04/11 00:00 [revised] PHST- 2025/04/18 00:00 [accepted] PHST- 2025/05/31 00:36 [medline] PHST- 2025/04/25 01:21 [pubmed] PHST- 2025/04/24 18:05 [entrez] PHST- 2026/04/21 00:00 [pmc-release] AID - S1471-0153(25)00042-X [pii] AID - 10.1016/j.eatbeh.2025.101982 [doi] PST - ppublish SO - Eat Behav. 2025 Apr;57:101982. doi: 10.1016/j.eatbeh.2025.101982. Epub 2025 Apr 21. PMID- 40272775 OWN - NLM STAT- MEDLINE DCOM- 20250524 LR - 20261010 IS - 1867-0687 (Electronic) VI - 21 IP - 4 DP - 2025 Apr TI - Nomogram and scoring models based on BMI z-score, serum chlorine and urine specific gravity levels for predicting oral rehydration solution efficacy in pediatric postural orthostatic tachycardia syndrome. PG - 406-418 LID - 10.1007/s12519-025-00898-3 [doi] AB - BACKGROUND: Oral rehydration solution (ORS) is predominantly utilized in the management of hypovolemic postural orthostatic tachycardia syndrome (POTS). This study aimed to identify effective indicators and develop models to assess the impact of ORS on pediatric patients diagnosed with POTS. METHODS: We utilized a retrospective analysis of totally 158 pediatric patients with POTS receiving a 3-month course of ORS treatment. All patients were classified into training set (n = 98) and validation set (n = 60). Within the training set, univariate analysis and binary logistic regression were employed to select candidate predictors. To predict the efficacy of ORS in pediatric patients with POTS, a nomogram model and a scoring model were constructed and demonstrated. Additionally, the predictive ability and calibration performance were evaluated using receiver operating characteristic (ROC) curves, Hosmer-Lemeshow (H-L) goodness of fit test, and calibration plots. Decision curve analysis (DCA) was employed to assess the clinical applicability of the predictive models. RESULTS: Body mass index (BMI) z-score, serum chlorine, and urine specific gravity (USG) before treatment were identified as significant and independent predictors of efficacy of ORS in pediatric patients with POTS. Consequently, these indicators were included in the predictive models. A nomogram model was constructed in the training set (AUC = 0.87, which yields a sensitivity of 84.5% and a specificity of 85.0%) and validated in the validation set (the sensitivity, specificity, and accuracy were 87.5%, 85%, and 86.7%, respectively). A scoring model was advanced in the training set (AUC = 0.88, which yields a sensitivity of 79.3% and a specificity of 82.5%) and validated in the validation set (the sensitivity, specificity, and accuracy were 77.5%, 80.0%, and 78.3%, respectively). The H-L test results indicated a good model fit. The calibration plots and DCA for both models exhibited excellent calibration and satisfactory net benefit. CONCLUSIONS: Based on pre-treatment BMI z-score, serum chlorine, and USG, a nomogram model and a scoring model were developed and validated. The models can effectively assess the efficacy of ORS in pediatric patients with POTS, offering an accurate and individualized therapeutic strategy. CI - (c) 2025. Children's Hospital, Zhejiang University School of Medicine. FAU - Gao, Yu-Meng AU - Gao YM AD - Department of Pediatrics, Children's Medical Center, Peking University First Hospital, No. 8, Xi-Shi Ku Street, West District, Beijing, 100034, China. FAU - Xu, Bo-Wen AU - Xu BW AD - Department of Pediatrics, Children's Medical Center, Peking University First Hospital, No. 8, Xi-Shi Ku Street, West District, Beijing, 100034, China. AD - Department of Cardiology, Beijing Children's Hospital, Capital Medial University, Beijing, 100045, China. FAU - Liu, Ping AU - Liu P AD - Department of Pediatrics, Children's Medical Center, Peking University First Hospital, No. 8, Xi-Shi Ku Street, West District, Beijing, 100034, China. FAU - Wang, Yu-Li AU - Wang YL AD - Department of Pediatrics, Children's Medical Center, Peking University First Hospital, No. 8, Xi-Shi Ku Street, West District, Beijing, 100034, China. FAU - Zhang, Qing-You AU - Zhang QY AD - Department of Pediatrics, Children's Medical Center, Peking University First Hospital, No. 8, Xi-Shi Ku Street, West District, Beijing, 100034, China. FAU - Liao, Ying AU - Liao Y AD - Department of Pediatrics, Children's Medical Center, Peking University First Hospital, No. 8, Xi-Shi Ku Street, West District, Beijing, 100034, China. liaoyingwww@163.com. FAU - Du, Jun-Bao AU - Du JB AD - Department of Pediatrics, Children's Medical Center, Peking University First Hospital, No. 8, Xi-Shi Ku Street, West District, Beijing, 100034, China. junbaodu1@126.com. AD - State Key Laboratory of Vascular Homeostasis and Remodelling, Peking University, Beijing, 100083, China. junbaodu1@126.com. FAU - Jin, Hong-Fang AU - Jin HF AD - Department of Pediatrics, Children's Medical Center, Peking University First Hospital, No. 8, Xi-Shi Ku Street, West District, Beijing, 100034, China. jinhongfang51@126.com. AD - State Key Laboratory of Vascular Homeostasis and Remodelling, Peking University, Beijing, 100083, China. jinhongfang51@126.com. LA - eng GR - PKU2022LCXQ028/Clinical Medicine Plus X-Young Scholars Project/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250424 PL - Switzerland TA - World J Pediatr JT - World journal of pediatrics : WJP JID - 101278599 RN - 4R7X1O2820 (Chlorine) RN - 0 (Rehydration Solutions) SB - IM MH - Humans MH - *Nomograms MH - Male MH - Female MH - Retrospective Studies MH - *Postural Orthostatic Tachycardia Syndrome/therapy/diagnosis/blood/urine MH - Child MH - *Body Mass Index MH - *Chlorine/blood MH - Specific Gravity MH - *Fluid Therapy/methods MH - Adolescent MH - *Rehydration Solutions/therapeutic use MH - Treatment Outcome MH - Predictive Value of Tests OTO - NOTNLM OT - Children OT - Nomogram model OT - Oral-rehydration solution OT - Postural orthostatic tachycardia syndrome OT - Scoring model COIS- Declarations. Conflict of interest: No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article. Author Junbao Du is a member of the Editorial Board for World Journal of Pediatrics. The paper was handled by the other editor and has undergone a rigorous peer review process. Author Junbao Du was not involved in the journal's review or decisions related to this manuscript. The authors have no conflict of interest to declare. Ethical approval: The Declaration of Helsinki's principles was followed in this study. The informed consent of all the parents or legal guardians of the participants were obtained prior to the participation. The study was approved by the Peking University First Hospital Ethics Committee in Beijing, China [2022(496)]. EDAT- 2025/04/24 12:30 MHDA- 2025/05/25 20:35 CRDT- 2025/04/24 11:25 PHST- 2024/12/15 00:00 [received] PHST- 2025/03/17 00:00 [accepted] PHST- 2025/03/12 00:00 [revised] PHST- 2025/05/25 20:35 [medline] PHST- 2025/04/24 12:30 [pubmed] PHST- 2025/04/24 11:25 [entrez] AID - 10.1007/s12519-025-00898-3 [pii] AID - 10.1007/s12519-025-00898-3 [doi] PST - ppublish SO - World J Pediatr. 2025 Apr;21(4):406-418. doi: 10.1007/s12519-025-00898-3. Epub 2025 Apr 24. PMID- 40270051 OWN - NLM STAT- MEDLINE DCOM- 20250424 LR - 20250426 IS - 1868-7083 (Electronic) IS - 1868-7075 (Print) IS - 1868-7075 (Linking) VI - 17 IP - 1 DP - 2025 Apr 23 TI - Applying blood-derived epigenetic algorithms to saliva: cross-tissue similarity of DNA-methylation indices of aging, physiology, and cognition. PG - 61 LID - 10.1186/s13148-025-01868-2 [doi] LID - 61 AB - BACKGROUND: Epigenetic algorithms of aging, health, and cognition, based on DNA-methylation (DNAm) patterns, are prominent tools for measuring biological age and have been linked to age-related diseases, cognitive decline, and mortality. While most of these methylation profile scores (MPSs) are developed in blood tissue, there is growing interest in using less invasive tissues like saliva. The aim of the current study is to probe the cross-tissue intraclass correlation coefficients (ICCs) of MPSs developed in blood applied to saliva DNAm from the same people. While our primary focus is on MPSs that were previously found to be robustly correlated with social determinants of health, including second- and third-generation clocks and MPSs of physiology and cognition, we also report ICC values for first-generation clocks to enable comparison across metrics. We pooled three publicly available datasets that had both saliva and blood DNAm from the same individuals (total n = 107, aged 5-74 years), corrected MPSs for cell composition within each tissue, and computed the cross-tissue ICCs. RESULTS: We found that after correcting for cell composition, saliva-blood cross-tissue ICCs were moderate for second- and third-generation indices of aging and MPSs of physiology and cognition. Specifically, PCGrimAge had the highest ICC (0.76), followed by PCPhenoAge (0.72), a measure of cognitive performance (Epigenetic-g, 0.69), DunedinPACE (0.68), PCGrimAge Acceleration (0.67), PCPhenoAge Acceleration (0.66), an MPS of hs-CRP (0.58), and BMI (0.54). These ICCs appear lower than previous reports on within-tissue ICCs (saliva ICCs range from 0.67 to 0.85, blood ICCs range from 0.73 to 0.93). Cross-tissue ICCs values for first-generation biological age acceleration measures were poor, ranging from 0.19 to 0.25. CONCLUSIONS: Our findings suggest that applying second- and third-generation MPSs of biological age acceleration and related phenotypes developed in blood to saliva DNAm results in moderate cross-tissue similarity and the precise cross-tissue correspondence differs by measure. While the degree of cross-tissue similarity of several MPSs may suffice for some research settings, it may not be suitable in clinical or commercial applications. Collection of both blood and saliva DNAm samples is necessary to validate existing algorithms and to customize MPSs in saliva DNAm. CI - (c) 2025. The Author(s). FAU - Zarandooz, Sepideh AU - Zarandooz S AD - Max Planck Research Group Biosocial - Biology, Social Disparities, and Development, Max Planck Institute for Human Development, Berlin, Germany. FAU - Raffington, Laurel AU - Raffington L AD - Max Planck Research Group Biosocial - Biology, Social Disparities, and Development, Max Planck Institute for Human Development, Berlin, Germany. raffington@mpib-berlin.mpg.de. LA - eng PT - Journal Article DEP - 20250423 PL - Germany TA - Clin Epigenetics JT - Clinical epigenetics JID - 101516977 SB - IM MH - Humans MH - *Saliva/chemistry MH - *DNA Methylation/genetics MH - Middle Aged MH - Adult MH - Aged MH - Male MH - *Aging/genetics MH - Female MH - Algorithms MH - Adolescent MH - Young Adult MH - *Cognition/physiology MH - *Epigenesis, Genetic MH - Child MH - Child, Preschool MH - *Epigenomics/methods PMC - PMC12016411 OTO - NOTNLM OT - Biological aging OT - Blood OT - Cross-tissue similarity OT - DNA methylation OT - Saliva COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/04/24 06:27 MHDA- 2025/04/24 06:28 PMCR- 2025/04/23 CRDT- 2025/04/24 04:07 PHST- 2024/11/03 00:00 [received] PHST- 2025/03/29 00:00 [accepted] PHST- 2025/04/24 06:28 [medline] PHST- 2025/04/24 06:27 [pubmed] PHST- 2025/04/24 04:07 [entrez] PHST- 2025/04/23 00:00 [pmc-release] AID - 10.1186/s13148-025-01868-2 [pii] AID - 1868 [pii] AID - 10.1186/s13148-025-01868-2 [doi] PST - epublish SO - Clin Epigenetics. 2025 Apr 23;17(1):61. doi: 10.1186/s13148-025-01868-2. PMID- 40269876 OWN - NLM STAT- MEDLINE DCOM- 20250424 LR - 20250501 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Apr 23 TI - The effects of physical activity on the mental health of typically developing children and adolescents: a systematic review and meta-analysis. PG - 1514 LID - 10.1186/s12889-025-22690-8 [doi] LID - 1514 AB - BACKGROUND: Physical activity has gained attention in recent years as a promising intervention for improving the mental health of children and adolescents. However, evidence supporting the effectiveness of physical activity interventions for the mental health of typically developing children and adolescents remains limited. METHODS: This study conducted a comprehensive search across five electronic databases up to July 2024. Studies were eligible for inclusion if they involved an intervention with a control group that examined the effects of physical activity on the mental health of typically developing children and adolescents. Articles focusing on participants with developmental, behavioral, or psychiatric disorders were excluded. A random-effects meta-analysis was conducted using Stata 18.0. The quality of evidence and risk of bias were assessed using the GRADE framework and the PEDro scale. RESULTS: The initial search yielded 27,527 articles, of which 30 met the inclusion criteria. Meta-regression analysis indicated that country and intervention frequency were significant sources of heterogeneity. Physical activity interventions were significantly more effective than the control group in improving mental health (SMD = 0.37, 95% CI: 0.20 to 0.53). These interventions showed particularly strong effects on stress reduction (SMD = 0.86, 95% CI: 0.15 to 1.56) and social competence enhancement (SMD = 0.56, 95% CI: 0.07 to 1.06). Moreover, physical activity interventions were notably more effective for male adolescents (SMD = 1.11, 95% CI: 0.34 to 1.88) and those at the secondary school level (SMD = 0.45, 95% CI: 0.23 to 1.69). CONCLUSIONS: Physical activity is beneficial in improving various aspects of mental health, including anxiety, depression, stress, self-esteem, and social competence in typically developing children and adolescents. However, the quality of evidence in this study is low due to methodological limitations of the studies included in this review. More high-quality randomized controlled trials are needed to validate these findings. Teachers and community workers can leverage physical activity as a preventive strategy to promote the mental health of children and adolescents. Future research should also investigate how factors like socioeconomic status and the sporting environment impact the effectiveness of these interventions. TRIAL REGISTRATION: PROSPERO, CRD42024567153. CI - (c) 2025. The Author(s). FAU - Fu, Quan AU - Fu Q AD - Capital University of Physical Education and Sports, Beijing, 100191, China. fuquan@cupes.edu.cn. FAU - Li, Longhui AU - Li L AD - Capital University of Physical Education and Sports, Beijing, 100191, China. FAU - Li, Qiner AU - Li Q AD - Capital University of Physical Education and Sports, Beijing, 100191, China. FAU - Wang, Jingyi AU - Wang J AD - Capital University of Physical Education and Sports, Beijing, 100191, China. LA - eng GR - CIT&TCD20180335/Beijing Municipal University Great Wall Scholar Training Program Project/ GR - KXYJS2024007/China Association for Science and Technology Graduate Student Science Popularization Ability Improvement/ PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20250423 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Adolescent MH - *Exercise/psychology MH - Child MH - *Mental Health PMC - PMC12016293 OTO - NOTNLM OT - Adolescents OT - Children OT - Mental health OT - Meta-analysis OT - Physical activity COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/04/24 06:27 MHDA- 2025/04/24 12:30 PMCR- 2025/04/23 CRDT- 2025/04/24 03:45 PHST- 2024/11/26 00:00 [received] PHST- 2025/04/08 00:00 [accepted] PHST- 2025/04/24 12:30 [medline] PHST- 2025/04/24 06:27 [pubmed] PHST- 2025/04/24 03:45 [entrez] PHST- 2025/04/23 00:00 [pmc-release] AID - 10.1186/s12889-025-22690-8 [pii] AID - 22690 [pii] AID - 10.1186/s12889-025-22690-8 [doi] PST - epublish SO - BMC Public Health. 2025 Apr 23;25(1):1514. doi: 10.1186/s12889-025-22690-8. PMID- 40266441 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20261008 IS - 1573-3432 (Electronic) IS - 0162-3257 (Linking) VI - 56 IP - 10 DP - 2026 Oct TI - Development and Further Content Validation of the Motivation Assessment Tool for Physical Activity (MATPA) Among Children with Autism Spectrum Disorder. PG - 3952-3969 LID - 10.1007/s10803-025-06824-w [doi] AB - This study describes the content validity process, focusing on children, to create and validate a tool for assessing motivation toward out-of-school physical activity (PA) among children with autism spectrum disorder (ASD) aged 6 to 17 years. Additionally, it establishes the eligible verbal communication age range necessary for its application. The initial development and content validity process with external experts is described elsewhere (An et al., 2025 under review). The MAT-PA was iteratively refined during the content validity process with twenty children (two with version 0.1, ten with version 0.2, and eight with version 0.3). Modifications were made based on feedback from children who completed the entire interview. The Vineland Adaptive Behavior Scales, Second Edition (VABS-2), assessed the age-equivalent for daily verbal communication skills required for the MAT-PA. Feedback from the twelve children who completed the entire interview process (two with version 0.1, six with version 0.2, and four with version 0.3) provided evidence supporting the tool's content validity. Challenges with attention spans and verbal abilities limited full participation from the remaining eight children. Parent-reported VABS-2 scores indicated that the MAT-PA is suitable for children with ASD who have verbal communication skills equivalent to 3-year-olds (receptive) and 6-year-olds (expressive). The MAT-PA is the first tool specifically designed to explore the psychological needs and behavioral regulation of children with ASD, providing evidence of content validity. Future work should focus on improving the tool's reliability for trial integration, exploring its applicability across diverse contexts, and leveraging technology to boost scalability and impact. CI - (c) 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - An, Mi AU - An M AUID- ORCID: 0000-0002-3289-9984 AD - Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan. nilo23452345@gmail.com. FAU - Sasai, Takehiro AU - Sasai T AD - Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan. FAU - Ito, Ryotaro AU - Ito R AD - Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan. FAU - Inoue, Mayumi AU - Inoue M AD - Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan. FAU - Komaki, Misa AU - Komaki M AD - Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan. FAU - Kusano, Yusuke AU - Kusano Y AUID- ORCID: 0000-0002-8580-546X AD - Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan. FAU - Tabata, Ami AU - Tabata A AUID- ORCID: 0000-0002-1356-9306 AD - Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan. FAU - Bardid, Farid AU - Bardid F AUID- ORCID: 0000-0001-8591-0596 AD - Strathclyde Institute of Education, University of Strathclyde, Glasgow, UK. FAU - Fitton Davies, Katie AU - Fitton Davies K AUID- ORCID: 0000-0002-1853-9667 AD - School of Sport and Exercise Sciences, Faculty of Science, Liverpool John Moores University, Liverpool, UK. FAU - Foweather, Lawrence AU - Foweather L AUID- ORCID: 0000-0001-9851-5421 AD - School of Sport and Exercise Sciences, Faculty of Science, Liverpool John Moores University, Liverpool, UK. FAU - Knowles, Zoe AU - Knowles Z AUID- ORCID: 0000-0003-1129-2275 AD - School of Sport and Exercise Sciences, Faculty of Science, Liverpool John Moores University, Liverpool, UK. FAU - Roberts, Simon J AU - Roberts SJ AUID- ORCID: 0000-0001-7370-0161 AD - School of Sport and Exercise Sciences, Faculty of Science, Liverpool John Moores University, Liverpool, UK. FAU - Rudd, James AU - Rudd J AUID- ORCID: 0000-0003-1546-576X AD - Department of Teacher Education and Outdoor Studies, Norwegian School of Sport Sciences, Oslo, Norway. FAU - Kato, Toshihiro AU - Kato T AUID- ORCID: 0000-0002-1468-5405 AD - Faculty of Rehabilitation, Kansai Medical University, Osaka, Japan. LA - eng PT - Journal Article PT - Validation Study DEP - 20250423 PL - United States TA - J Autism Dev Disord JT - Journal of autism and developmental disorders JID - 7904301 SB - IM MH - Humans MH - Child MH - *Autism Spectrum Disorder/psychology MH - *Motivation MH - Male MH - Female MH - Adolescent MH - *Exercise/psychology MH - Reproducibility of Results MH - Psychometrics OTO - NOTNLM OT - Assessment OT - Autism spectrum disorder OT - Children OT - Motivation OT - Out-of-school physical activity OT - Self-Determination Theory COIS- Declarations. Conflict of interest: The authors have no competing interests to declare that are relevant to the content of this article. Ethical Approval: All procedures undertaken in the current study were in accordance with ethical standards and received approval from Ethics Committee, Graduate School and Faculty of Medicine, Kyoto University (R4063-2). Informed Consent and Informed Assent: Informed Consent was obtained from all parents and all children who are or older than 16 years old included in the study. Informed Assent was obtained from children aged 7-15 years old included in the study. EDAT- 2025/04/23 12:27 MHDA- 2026/09/03 01:13 CRDT- 2025/04/23 11:21 PHST- 2025/03/30 00:00 [accepted] PHST- 2026/09/03 01:13 [medline] PHST- 2025/04/23 12:27 [pubmed] PHST- 2025/04/23 11:21 [entrez] AID - 10.1007/s10803-025-06824-w [pii] AID - 10.1007/s10803-025-06824-w [doi] PST - ppublish SO - J Autism Dev Disord. 2026 Oct;56(10):3952-3969. doi: 10.1007/s10803-025-06824-w. Epub 2025 Apr 23. PMID- 40265988 OWN - NLM STAT- MEDLINE DCOM- 20250423 LR - 20250423 IS - 1470-3556 (Print) IS - 1470-3556 (Linking) VI - 39 IP - 2 DP - 2025 Spring TI - Development, Validation, and Feasibility of Yoga Intervention Module for Optimizing Safe Use of Screen Time: A Pilot Study. PG - 9-16 AB - CONTEXT: Frequent screen use in adolescents is linked to adverse health effects. Yoga practice fosters self-regulation, which can help limit screen time and promote healthy behaviors. This study developed and validated a first-of-its-kind yoga module to minimize excessive screen time among adolescents. OBJECTIVE: This pilot study aimed to assess the feasibility and potential efficacy of yoga intervention in promoting healthy screen time regulation and reducing related symptoms like depression, anxiety, eye strain, and physical health issues. DESIGN AND SETTING: A yoga module was designed using the Integrative Approach to Yoga Therapy, incorporating holistic yogic principles. The study was conducted at the Swami Vivekananda Yoga Anusandhana Samsthana (S-VYASA) University, Bengaluru, India. PARTICIPANTS: The module was developed and validated by 26 yoga professors from various yoga schools in India. The pilot study included 26 female adolescents (ages 16-17 years) from Bengaluru, South India. INTERVENTION: The intervention group underwent a four-week, expert-approved integrated yoga program comprising 12 sessions of 45-minute yoga techniques. The control group received digital hygiene education. OUTCOME MEASURES: Content validity was assessed using Lawshe's Content Validity Ratio (CVR), and standard questionnaires were used to measure screen time, anxiety (GAD-7), depression (PHQ-9), well-being (WHO-5, KIDSCREEN-10), and smartphone addiction (SAS-SV). RESULTS: Six practices were removed due to low CVR scores, and 21 out of 27 validated practices were retained in the final module (CVI = 0.72). After 12 yoga sessions, participants showed a significant decline in screen time and associated complications. CONCLUSION: The study suggests that yoga reduces anxiety and depression, enhances physical and psychological well-being, and improves self-regulation, leading to a decline in excessive screen time behaviors. FAU - Mona, Manisha AU - Mona M FAU - Kumari, Sony AU - Kumari S FAU - Anand, Nitin AU - Anand N FAU - Sharma, Manoj Kumar AU - Sharma MK LA - eng PT - Journal Article PT - Validation Study PL - United States TA - Adv Mind Body Med JT - Advances in mind-body medicine JID - 9813115 SB - IM MH - Humans MH - *Yoga MH - Pilot Projects MH - Female MH - Adolescent MH - Feasibility Studies MH - *Screen Time MH - *Anxiety/therapy MH - India MH - Depression/therapy MH - *Adolescent Behavior/physiology EDAT- 2025/04/23 12:28 MHDA- 2025/04/23 12:29 CRDT- 2025/04/23 09:32 PHST- 2025/04/23 12:29 [medline] PHST- 2025/04/23 12:28 [pubmed] PHST- 2025/04/23 09:32 [entrez] AID - ADV1353 [pii] PST - ppublish SO - Adv Mind Body Med. 2025 Spring;39(2):9-16. PMID- 40265228 OWN - NLM STAT- MEDLINE DCOM- 20251205 LR - 20260424 IS - 1461-7277 (Electronic) IS - 1359-1053 (Print) IS - 1359-1053 (Linking) VI - 30 IP - 14 DP - 2025 Dec TI - Psychometric properties of the Power of Food Scale during pregnancy and postpartum. PG - 4206-4223 LID - 10.1177/13591053251333244 [doi] AB - Hedonic hunger, pleasure-driven motivation to consume highly palatable foods independent of physical hunger, was conceptualized as a stable trait, yet may differ with biopsychosocial changes during pregnancy and postpartum. This study examined measurement equivalence and convergent validity of the Power of Food Scale (PFS), a measure of hedonic hunger, throughout pregnancy (each trimester) and postpartum (6 and 12 months) in N = 458 mothers in North Carolina, United States (Pregnancy Eating Attributes Study; 67.3% White, 15.1% Black) and in comparison to young adult women (N = 1333 from the NEXT Generation Health Study; 60.8% White, 15.8% Black). Confirmatory factor analysis supported longitudinal equivalence in pregnant/postpartum individuals and partial equivalence with young adult women. Associations of PFS with emotional eating, external eating, and delay of gratification supported convergent validity. PFS functions as expected during pregnancy and postpartum. Item-level comparisons to primarily non-pregnant populations should be avoided. Cognitive interviews may clarify item interpretations during pregnancy and postpartum. FAU - Mooney, Jan T AU - Mooney JT AUID- ORCID: 0000-0002-5632-4958 AD - University of North Carolina at Charlotte, USA. AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, USA. FAU - Webb, Jennifer B AU - Webb JB AUID- ORCID: 0000-0002-6033-5844 AD - University of North Carolina at Charlotte, USA. FAU - Lipsky, Leah M AU - Lipsky LM AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, USA. FAU - Dahl, Alicia A AU - Dahl AA AD - University of North Carolina at Charlotte, USA. FAU - Quinlan, Margaret M AU - Quinlan MM AD - University of North Carolina at Charlotte, USA. FAU - Nansel, Tonja R AU - Nansel TR AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, USA. LA - eng GR - HHSN275201300015C/HD/NICHD NIH HHS/United States GR - ZIA HD008942/ImNIH/Intramural NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, N.I.H., Intramural DEP - 20250423 PL - England TA - J Health Psychol JT - Journal of health psychology JID - 9703616 SB - IM MH - Humans MH - Female MH - *Postpartum Period/psychology MH - Pregnancy MH - Psychometrics MH - Adult MH - Young Adult MH - North Carolina MH - Reproducibility of Results MH - *Feeding Behavior/psychology MH - *Hunger MH - Surveys and Questionnaires MH - Adolescent MH - Factor Analysis, Statistical PMC - PMC12314745 MID - NIHMS2098012 OTO - NOTNLM OT - Power of Food Scale OT - appetite OT - hedonic hunger OT - postpartum OT - pregnancy COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/04/23 06:26 MHDA- 2025/12/05 13:07 PMCR- 2026/04/23 CRDT- 2025/04/23 04:43 PHST- 2025/12/05 13:07 [medline] PHST- 2025/04/23 06:26 [pubmed] PHST- 2025/04/23 04:43 [entrez] PHST- 2026/04/23 00:00 [pmc-release] AID - 10.1177/13591053251333244 [doi] PST - ppublish SO - J Health Psychol. 2025 Dec;30(14):4206-4223. doi: 10.1177/13591053251333244. Epub 2025 Apr 23. PMID- 40265074 OWN - NLM STAT- MEDLINE DCOM- 20250423 LR - 20250424 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Development and validation of a nutrition assessment questionnaire based on the social and behavior change model for adolescents in Ethiopia. PG - 1474815 LID - 10.3389/fpubh.2025.1474815 [doi] LID - 1474815 AB - BACKGROUND: A reliable assessment of behavior change requires the use of a validated tool based on an appropriate behavior change model. Research on tools for assessing nutrition behavior change is limited. OBJECTIVE: This study aimed to develop and validate a questionnaire for assessing plant-protein food consumption behaviors based on Pender's behavior change model, specifically for adolescent girls in Ethiopia. METHODS: A collection of items was generated by examining relevant behavior change theories and manuals, dietary guidelines, and literature focused on pulses' food function, processing, and preparation. The items were examined for content and face validity. Exploratory factor analysis was performed after verifying its assumptions, such as the factorability of the instrument using Bartlett's test of sphericity and Kaiser-Meyer-Olkin (KMO) measure of sampling adequacy. Eigenvalue and scree plot were used to determine the number of factors. Factor loadings and communalities were employed for item retention. Cronbach's alpha was calculated to assess the reliability at the scale and dimension levels. RESULTS: Of the 53 items analyzed, 29 items and 6 factors were retained. The overall scale-level reliability was measured at 0.7210, while the factor-level reliabilities were as follows: 0.69 for factor 1 (i48, i49, i50, i52, i53, i31, and i32), 0.67 for factor 2 (i7, i8, i9, i10, i12, i13, and i14), 0.63 for factor 3 (i23, i24, i25, i26, fi27, and i28), 0.31 for factor 4 (i4, i5, i40), 0.59 for factor 5 (i35, i36, and i37), and 0.58 for factor 6 (i18, i19, and i20). CONCLUSION: The tool has an acceptable scale-level reliability. The factors are theoretically meaningful and align with the recommendations. The tool can serve as a foundation for developing tools in related fields. However, it requires further refinement before it can be used as a standard tool. CI - Copyright (c) 2025 Mekonnen, Biks, Azale and Mengistu. FAU - Mekonnen, Fantahun Ayenew AU - Mekonnen FA AD - Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. FAU - Biks, Gashaw Andargie AU - Biks GA AD - Department of Health Systems and Policy, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. FAU - Azale, Telake AU - Azale T AD - Department of Health Education and Behavioral Sciences, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. FAU - Mengistu, Netsanet Worku AU - Mengistu NW AD - Department of Human Nutrition, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. LA - eng PT - Journal Article PT - Validation Study DEP - 20250408 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Ethiopia MH - Adolescent MH - Female MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - *Nutrition Assessment MH - *Feeding Behavior/psychology MH - Factor Analysis, Statistical PMC - PMC12011774 OTO - NOTNLM OT - dietary behavior OT - questionnaire OT - reliability OT - social and behavior change OT - validity COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/04/23 11:18 MHDA- 2025/04/23 12:28 PMCR- 2025/04/08 CRDT- 2025/04/23 04:22 PHST- 2024/09/17 00:00 [received] PHST- 2025/02/17 00:00 [accepted] PHST- 2025/04/23 12:28 [medline] PHST- 2025/04/23 11:18 [pubmed] PHST- 2025/04/23 04:22 [entrez] PHST- 2025/04/08 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1474815 [doi] PST - epublish SO - Front Public Health. 2025 Apr 8;13:1474815. doi: 10.3389/fpubh.2025.1474815. eCollection 2025. PMID- 40264967 OWN - NLM STAT- MEDLINE DCOM- 20250423 LR - 20250424 IS - 1661-8564 (Electronic) IS - 1661-8556 (Print) IS - 1661-8556 (Linking) VI - 70 DP - 2025 TI - Ultra-Processed Food Consumption Among College Students and Their Association With Body Composition, Bowel Movements and Menstrual Cycle. PG - 1607712 LID - 10.3389/ijph.2025.1607712 [doi] LID - 1607712 AB - OBJECTIVES: The current research aimed to explore the association of ultra-processed food consumption among college students with body composition, bowel movements, and menstrual irregularities with a focus on females. METHODS: A cross-sectional study was conducted in Pune, India among 110 university students of both genders aged 18-25 years. A developed and validated Food Frequency Questionnaire (FFQ) based on the NOVA classification was used to evaluate UPF consumption, while the Constipation Scoring System (CSS) and the Premenstrual Symptoms Screening Tool assessed bowel habits and menstrual health, respectively. Anthropometric measurements, including BMI, body fat percentage,and visceral fat were recorded using an Omron Karada Analyzer. RESULTS: A higher percentage of participants were female (74.8%). Most participants (52.3%) consumed more than three meals daily, while 42.1% ate outside food 2-3 times per week. Higher UPF consumption showed a trend toward increased body fat (p = 0.053) and was significantly associated with greater visceral fat accumulation (p < 0.05). No significant associations were found between UPF intake and bowel movement, gastrointestinal symptoms, or menstrual cycle irregularities (p > 0.05). CONCLUSION: Higher UPF consumption showed a trend toward increased body fat percentage, though not statistically significant. These findings highlight the need to reduce UPF intake to mitigate potential risks of increased adiposity and metabolic disturbances. CI - Copyright (c) 2025 Ghosh and Muley. FAU - Ghosh, Anindita AU - Ghosh A AD - Department of Nutritional Sciences and Dietetics, Symbiosis Skills and Professional University, Pune, Maharashtra, India. FAU - Muley, Arti AU - Muley A AD - Department of Nutrition and Dietetics, Symbiosis School of Culinary Arts and Nutritional Sciences (SSCANS), Symbiosis International (Deemed University), Pune, Maharashtra, India. LA - eng PT - Journal Article DEP - 20250408 PL - Switzerland TA - Int J Public Health JT - International journal of public health JID - 101304551 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Young Adult MH - Adult MH - Adolescent MH - *Students/statistics & numerical data MH - *Body Composition MH - India/epidemiology MH - Male MH - *Fast Foods/statistics & numerical data/adverse effects MH - Universities MH - *Menstrual Cycle/physiology MH - *Menstruation Disturbances/epidemiology/etiology MH - Constipation/epidemiology MH - Feeding Behavior MH - *Defecation MH - Surveys and Questionnaires MH - Body Mass Index MH - Food, Processed PMC - PMC12011617 OTO - NOTNLM OT - body composition OT - body mass index OT - bowel movements OT - irregular menstrual cycle OT - ultra-processed food choices COIS- The authors declare that they do not have any conflicts of interest. EDAT- 2025/04/23 11:18 MHDA- 2025/04/23 17:15 PMCR- 2025/04/08 CRDT- 2025/04/23 04:21 PHST- 2024/06/30 00:00 [received] PHST- 2025/03/24 00:00 [accepted] PHST- 2025/04/23 17:15 [medline] PHST- 2025/04/23 11:18 [pubmed] PHST- 2025/04/23 04:21 [entrez] PHST- 2025/04/08 00:00 [pmc-release] AID - 1607712 [pii] AID - 10.3389/ijph.2025.1607712 [doi] PST - epublish SO - Int J Public Health. 2025 Apr 8;70:1607712. doi: 10.3389/ijph.2025.1607712. eCollection 2025. PMID- 40264136 OWN - NLM STAT- MEDLINE DCOM- 20250423 LR - 20250425 IS - 1477-7827 (Electronic) IS - 1477-7827 (Linking) VI - 23 IP - 1 DP - 2025 Apr 22 TI - Maternal obesity and the incidence of large-for-gestational-age newborns in isolated hypothyroxinemia pregnancies: a comparative cohort study. PG - 60 LID - 10.1186/s12958-025-01394-z [doi] LID - 60 AB - BACKGROUND: The synergistic impact of isolate maternal hypothyroxinaemia (IMH) and other modulators on fetal growth outcomes is unknown. This study was aimed to determine whether third trimester IMH [free thyroxine level (FT4) below the the 5th percentile and thyroid stimulating hormone (TSH) between the 5th and 95th percentiles] and prenatal body mass index (BMI) jointly increase the risk of large for gestational age (LGA) deliveries. METHODS: A retrospective analysis was conducted on 11,478 Chinese pregnant women with laboratory data (including thyroid hormone levels and routine biochemical tests) and hospitalization records from a specialized hospital. RESULTS: The prevalence of obesity (BMI >/= 30 kg/m(2)) and IMH was 20.1% (2312/11478) and 4.5% (519/11478), retrospectively. Women with obesity had a 6.96-fold greater risk of IMH (95% CI: 4.58, 10.58) and a 5.88-fold increased risk of LGA (95% CI: 4.87, 7.11) than those with normal weight (BMI < 25 kg/m(2)), while women with IMH had a 1.32-fold increased risk of LGA (95% CI: 1.05, 1.65) than euthyroid women. The positive associations of LGA risk with obesity and IMH remained robust in sensitivity analyses conducted among women aged < 35 years, primiparas, and those without pregnancy complications. Compared to euthyroid women with normal weight, women with obesity and IMH had a 7.60-fold higher risk of LGA (95% CI: 5.26, 10.97). Additionally, a significant interaction between BMI categories and IMH on LGA was observed (P < 0.013). Subgroup analyses validated this interaction among women with aged < 35 years, multiparity, and non-pregnancy complications. CONCLUSIONS: Obesity and IMH in late pregnancy are both associated with an increased risk of LGA newborns, and their coexistence may further amplifies this risk; prenatal BMI and thyroid hormone levels could serve as potential indicators for identifying individuals at elevated LGA risk. CI - (c) 2025. The Author(s). FAU - Zhang, Bin AU - Zhang B AD - Department of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, China. FAU - Xi, Sijie AU - Xi S AD - Department of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, China. FAU - Zhan, Zhaolong AU - Zhan Z AD - Department of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, China. FAU - Zhang, Yinglu AU - Zhang Y AD - Department of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, China. FAU - Lu, Fengying AU - Lu F AD - Department of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, China. FAU - Yuan, Xiaosong AU - Yuan X AD - Department of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, China. xiaosongyuan@njmu.edu.cn. LA - eng GR - CJ20230078/Changzhou Applied Basic Research Project/ GR - H2023131/General project of Jiangsu Provincial Health Commission/ GR - CMCC202219/Changzhou Medical Center of Nanjing Medical University/ GR - CM20240013/Changzhou Key Laboratory of Maternal and Child Health Medicine/ PT - Comparative Study PT - Journal Article DEP - 20250422 PL - England TA - Reprod Biol Endocrinol JT - Reproductive biology and endocrinology : RB&E JID - 101153627 RN - Q51BO43MG4 (Thyroxine) SB - IM MH - Humans MH - Female MH - Pregnancy MH - Adult MH - Retrospective Studies MH - Infant, Newborn MH - *Thyroxine/blood MH - *Pregnancy Complications/epidemiology/blood MH - *Hypothyroidism/epidemiology/blood/complications MH - Incidence MH - Body Mass Index MH - *Fetal Macrosomia/epidemiology/etiology/blood MH - *Pregnancy in Obesity/epidemiology/blood MH - China/epidemiology MH - Cohort Studies MH - *Obesity/epidemiology/complications MH - Gestational Age MH - Young Adult MH - Birth Weight/physiology PMC - PMC12013030 OTO - NOTNLM OT - Birthweight OT - Body mass index OT - Isolate maternal hypothyroxinaemia OT - Large for gestational age OT - Obesity OT - Thyroid hormone COIS- Declarations. Ethics approval and consent to participate: The study protocol was approved by the Ethical Committee of Changzhou Maternal and Child Health Care Hospital (ZD201803). Due to anonymous data recorded in the present study, the requirements for written informed consent were waived by the Ethical Committee of Changzhou Maternal and Child Health Care Hospital. All methods in this study were carried out in accordance with relevant guidelines and regulations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. Clinical trial number: Not applicable. EDAT- 2025/04/23 06:25 MHDA- 2025/04/23 12:28 PMCR- 2025/04/22 CRDT- 2025/04/23 02:29 PHST- 2025/01/06 00:00 [received] PHST- 2025/04/08 00:00 [accepted] PHST- 2025/04/23 12:28 [medline] PHST- 2025/04/23 06:25 [pubmed] PHST- 2025/04/23 02:29 [entrez] PHST- 2025/04/22 00:00 [pmc-release] AID - 10.1186/s12958-025-01394-z [pii] AID - 1394 [pii] AID - 10.1186/s12958-025-01394-z [doi] PST - epublish SO - Reprod Biol Endocrinol. 2025 Apr 22;23(1):60. doi: 10.1186/s12958-025-01394-z. PMID- 40264076 OWN - NLM STAT- MEDLINE DCOM- 20250423 LR - 20250425 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Apr 22 TI - Nutritional status, psychological status and quality of life of adolescents in selected childcare institutions in the Galle district of Sri Lanka. PG - 1474 LID - 10.1186/s12889-025-22573-y [doi] LID - 1474 AB - INTRODUCTION: Adolescence is a most unique stage of human development and lays the foundation for future well-being and good health. Institutionalization is considered a protective means for children when they are not protected and cared for by their original family. OBJECTIVES: This study aimed to assess nutritional status, psychological status and quality of life (QoL) of adolescents in child care institutions in the Galle district. METHODS: A descriptive cross-sectional study was conducted enrolling 320 subjects in childcare institutions (n = 12) in the Galle district. Nutritional status was assessed via BMI and nutritional intake was assessed via dietary recall. Psychological status and QoL were assessed via validated Sinhala versions of the Depression Anxiety and Stress Scale (DASS 21) and Peds QLTM Generic 4.0 core scale, respectively. RESULTS: Among the participants (response rate: 90%), 60.6% (n = 194) were females. The age range of the subjects was 10-19 years. Poor protection in society, poverty and disobedience were the most common reasons for entering child care institutions. With respect to educational status, performance in selected subjects were average except English language. The nutritional status of the majority of the participants was satisfactory (57.8% were normal weight), and only 11.3%. had been underweight. Recommended servings for cereals/starchy food and pulses were obtained by only 34.7% and 29.7% of the adolescents, respectively. The majority of the participants had mild to extremely severe depression (n = 224, 70%), and half of the participants experienced anxiety (n = 166, 51.9%). The prevalence of stress was low in this sample (n = 97, 30.3%). The mean scores for all four domains of QoL were above 50%, indicating satisfactory QoL. There was a statistically significant association between parental status and psychological status (p < 0. 05), and stress was significantly (p < 0.005) associated with three domains of QoL other than social functioning. CONCLUSION: The majority of the subjects in this sample were females. Poor protection in society was the most common reason for entering childcare institutions. The nutritional status of the majority of the subjects was satisfactory whereas the majority of them were not getting recommended servings of cereals/starchy food and pulses. Depression was prevalent in the majority of the subjects, and half of them experienced anxiety. The prevalence of stress was low in this sample. The overall QoL of the adolescents was satisfactory. Three domains of QoL were significantly associated with stress (p < 0.005), and parental status and psychological status were significantly associated (p < 0. 05). CI - (c) 2025. The Author(s). FAU - De Zilva, Ltk AU - De Zilva L AD - Department of Nursing, Faculty of Allied Health Sciences, University of Ruhuna, Galle, Sri Lanka. FAU - De Zoysa, Eric AU - De Zoysa E AD - Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka. eric@med.ruh.ac.lk. LA - eng PT - Journal Article DEP - 20250422 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - Adolescent MH - Male MH - *Nutritional Status MH - *Quality of Life/psychology MH - Cross-Sectional Studies MH - Child MH - Sri Lanka/epidemiology MH - Young Adult MH - *Child Day Care Centers PMC - PMC12013042 OTO - NOTNLM OT - Institutionalized adolescents OT - Nutritional status OT - Psychological status OT - Quality of life COIS- Declarations. Ethics approval and consent to participate: The study received approval from the Ethics Review Committee of the Faculty of Allied Health Sciences, University of Ruhuna, Sri Lanka, in accordance with the Declaration of Helsinki, and those who were willing to participate in the study were recruited after obtaining the written informed consent. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/04/23 06:26 MHDA- 2025/04/23 12:28 PMCR- 2025/04/22 CRDT- 2025/04/23 02:26 PHST- 2024/12/20 00:00 [received] PHST- 2025/04/01 00:00 [accepted] PHST- 2025/04/23 12:28 [medline] PHST- 2025/04/23 06:26 [pubmed] PHST- 2025/04/23 02:26 [entrez] PHST- 2025/04/22 00:00 [pmc-release] AID - 10.1186/s12889-025-22573-y [pii] AID - 22573 [pii] AID - 10.1186/s12889-025-22573-y [doi] PST - epublish SO - BMC Public Health. 2025 Apr 22;25(1):1474. doi: 10.1186/s12889-025-22573-y. PMID- 40264035 OWN - NLM STAT- MEDLINE DCOM- 20250423 LR - 20250425 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Apr 22 TI - Does accumulated family risk inhibit adolescent physical activity at home? An examination with a longitudinal latent growth model. PG - 1485 LID - 10.1186/s12889-025-22645-z [doi] LID - 1485 AB - BACKGROUND: The escalating prevalence of problem behaviors among adolescents, primarily stemming from accumulated family risk has emerged as a significant concern in contemporary school and family education. This phenomenon warrants particular attention as it may directly lead to reduced physical activity levels among adolescents within their domestic settings, potentially resulting in significant long-term consequences. Grounded in ecological systems theory, this study seeks to elucidate the cumulative effects of family risk on adolescent development. Through the application of a latent growth model across three distinct observation periods, we aim to systematically examine and clarify the longitudinal development trajectories and underlying interaction mechanisms of the variables under investigation. METHODS: A simple random cluster sampling method was utilized to select four middle schools from Sichuan Province, Guangdong Province, Hebei Province, and Beijing City as the research sites. A total of 682 primary and middle school students participated in three waves of follow-up surveys. Data were collected using validated scales, including the Accumulated Family Risk Scale and the Home Physical Activity Scale, to assess the respective constructs. RESULTS: (1) Adolescent accumulated family risk and home physical activity exhibited relative stability over the three observation periods, and a significant negative correlation was observed between these two variables. (2) The initial levels of adolescent home physical activity and accumulated family risk were significantly negatively correlated. Furthermore, these initial levels were found to significantly predict the growth rate of accumulated family risk, with the direction of influence being negative. CONCLUSION: The findings suggest that higher levels of physical activity and lower initial levels of accumulated family risk may serve as protective factors against the escalation of accumulated family risk levels during adolescence. These findings offer novel empirical evidence and theoretical insights for designing targeted interventions aimed at mitigating accumulated family risks among adolescents. CI - (c) 2025. The Author(s). FAU - Wu, Jingtao AU - Wu J AD - School of Physical Education, Leshan Normal University, Leshan, China. FAU - Shao, Yanhong AU - Shao Y AD - Xiangshui Teacher Development Center, Yancheng, China. FAU - Zhao, Wennan AU - Zhao W AD - School of Physical Education, Yanshan University, No. 438 West Hebei Street, Qinhuangdao City, Hebei Province, 066000, China. zhaown@ysu.edu.cn. FAU - Zang, Wanli AU - Zang W AD - Postgraduate School, Harbin Sport University, Harbin, China. FAU - Zhao, Xinjuan AU - Zhao X AD - School of Physical Education, Leshan Normal University, Leshan, China. FAU - Hu, Jun AU - Hu J AD - School of Physical Education, Leshan Normal University, Leshan, China. LA - eng GR - TY2021303/This study was supported by the project of the Sichuan Federation of Social Sciences/ GR - TY2021303/This study was supported by the project of the Sichuan Federation of Social Sciences/ GR - TY2021303/This study was supported by the project of the Sichuan Federation of Social Sciences/ GR - TY2021303/This study was supported by the project of the Sichuan Federation of Social Sciences/ GR - GT-02202104/the project of the Ziyang Federation of Social Sciences/ GR - GT-02202104/the project of the Ziyang Federation of Social Sciences/ GR - GT-02202104/the project of the Ziyang Federation of Social Sciences/ GR - GT-02202104/the project of the Ziyang Federation of Social Sciences/ GR - YXJKCB-2022-18/Zigong Medical and health communication research center: Research on the linkage effect of sports atmosphere and self-efficacy on college students' exercise behavior/ GR - YXJKCB-2022-18/Zigong Medical and health communication research center: Research on the linkage effect of sports atmosphere and self-efficacy on college students' exercise behavior/ GR - YXJKCB-2022-18/Zigong Medical and health communication research center: Research on the linkage effect of sports atmosphere and self-efficacy on college students' exercise behavior/ GR - KYPY2025-0014/the 2024 Research Cultivation Project of Leshan Normal University/ GR - KYPY2025-0014/the 2024 Research Cultivation Project of Leshan Normal University/ GR - KYPY2025-0014/the 2024 Research Cultivation Project of Leshan Normal University/ GR - KYPY2025-0014/the 2024 Research Cultivation Project of Leshan Normal University/ GR - KYPY2025-0014/the 2024 Research Cultivation Project of Leshan Normal University/ PT - Journal Article DEP - 20250422 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - Longitudinal Studies MH - *Exercise/psychology MH - China MH - *Adolescent Behavior/psychology MH - Child MH - Risk Factors MH - *Family/psychology PMC - PMC12013129 OTO - NOTNLM OT - Accumulated family risk OT - Adolescents OT - Development trajectory OT - Latent growth model OT - Physical activity COIS- Declarations. Ethics approval and consent to participate: This manuscript has not been reviewed elsewhere and as a result has not been previously published or accepted for publication. This manuscript has been read and approved by all authors. All methods were performed in accordance with relevant guidelines and regulations. The questionnaire and methodology of this study were approved by the Research Ethics Committee of the School of Physical Education and Sport, Leshan Normal College, prior to data collection. The ethics committee granted approval for the study to proceed as planned, under the approval number. LSEDU: 20220602. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/04/23 06:26 MHDA- 2025/04/23 06:27 PMCR- 2025/04/22 CRDT- 2025/04/23 02:25 PHST- 2023/10/18 00:00 [received] PHST- 2025/04/04 00:00 [accepted] PHST- 2025/04/23 06:27 [medline] PHST- 2025/04/23 06:26 [pubmed] PHST- 2025/04/23 02:25 [entrez] PHST- 2025/04/22 00:00 [pmc-release] AID - 10.1186/s12889-025-22645-z [pii] AID - 22645 [pii] AID - 10.1186/s12889-025-22645-z [doi] PST - epublish SO - BMC Public Health. 2025 Apr 22;25(1):1485. doi: 10.1186/s12889-025-22645-z. PMID- 40262739 OWN - NLM STAT- MEDLINE DCOM- 20250612 LR - 20250612 IS - 1543-2742 (Electronic) IS - 1526-484X (Linking) VI - 35 IP - 4 DP - 2025 Jul 1 TI - Current Resting Metabolic Rate Prediction Equations Lack Sensitivity and Specificity to Indicate Relative Energy Deficiency in Sport: A Large Cohort Study in Elite Athletes. PG - 324-336 LID - 10.1123/ijsnem.2024-0254 [doi] AB - OBJECTIVES: Measured resting metabolic rate (RMR) was compared to predicted RMR equations (RMRratio) to see whether a low RMRratio relates to the Relative Energy Deficiency in Sport (REDs) Clinical Assessment Tool 2 (CAT2) severity/risk score. METHODS: Female (n = 127) and male (n = 53) athletes (performance Tiers 3-5) were assigned green/yellow/orange/red light according to CAT2. RMR and submaximal exercise energy expenditure (via cycle ergometer) were assessed fasted on the same morning via indirect calorimetry. Low RMR was defined as RMRratio < 0.90, with 11 RMR prediction equations tested for sensitivity, specificity, and predictive validity against the CAT2. RESULTS: RMRratio (Cunningham) was only lower in red versus green light (0.90 +/- 0.07 vs. 0.99 +/- 0.10; p = .023; but RMRratio was only low in 44% of red light athletes). The prevalence of low RMRratio ranged from 1% (Owen equation) to 68% (van Hooren equation) despite the overall prevalence of REDs being 46%. As a diagnostic (no REDs [green] vs. REDs [yellow + orange + red]), Cunningham equation reported sensitivity (true positives) of 0.77 at RMRratio of 1.00 and specificity (true negatives) of 1.00 at RMRratio of 0.70. Exercise energy expenditure was significantly lower in green versus orange (0.131 +/- 0.013 vs. 0.142 +/- 0.008 kcal.kg fat-free mass-1.min-1; p < .001) but was greater in red (0.127 +/- 0.011) versus orange. CONCLUSION: Interpretation of RMRratio is radically impacted by choice of prediction equation. Although there may be some utility in cross-sectionally detecting extreme REDs cases (red light) via RMRratio, more research with a focus on sport/phenotype-specific prediction equations and varying risk thresholds is required to strengthen the validity and reliability of RMR as a part of REDs diagnostics. FAU - Heikura, Ida A AU - Heikura IA AUID- ORCID: 0000-0002-1088-428X AD - Canadian Sport Institute-Pacific, Victoria, BC, Canada. AD - Exercise Science, Physical & Health Education, University of Victoria, Victoria, BC, Canada. FAU - Tsai, Ming-Chang AU - Tsai MC AUID- ORCID: 0000-0002-3338-3306 AD - Canadian Sport Institute-Pacific, Victoria, BC, Canada. FAU - Sesbreno, Erik AU - Sesbreno E AUID- ORCID: 0000-0001-6793-7496 AD - Institut National du Sport du Quebec, Montreal, QC, Canada. AD - McGill University, Montreal, QC, Canada. AD - French-speaking Olympic Sports Medicine Research Network (ReFORM), Montreal, QC, Canada. FAU - McCluskey, Walter T P AU - McCluskey WTP AD - Canadian Sport Institute-Pacific, Victoria, BC, Canada. FAU - Johnson, Liz AU - Johnson L AD - Canadian Sport Institute-Pacific, Victoria, BC, Canada. FAU - Murray, Holly AU - Murray H AD - Canadian Sport Institute-Pacific, Victoria, BC, Canada. FAU - Stellingwerff, Trent AU - Stellingwerff T AUID- ORCID: 0000-0002-4704-8250 AD - Canadian Sport Institute-Pacific, Victoria, BC, Canada. AD - Exercise Science, Physical & Health Education, University of Victoria, Victoria, BC, Canada. LA - eng PT - Journal Article DEP - 20250422 PL - United States TA - Int J Sport Nutr Exerc Metab JT - International journal of sport nutrition and exercise metabolism JID - 100939812 SB - IM MH - Humans MH - Male MH - *Basal Metabolism MH - Female MH - Young Adult MH - Calorimetry, Indirect MH - Adult MH - Sensitivity and Specificity MH - Athletes MH - *Relative Energy Deficiency in Sport/diagnosis MH - Cohort Studies MH - Adolescent MH - *Sports Nutritional Physiological Phenomena MH - Energy Metabolism MH - Exercise MH - Exercise Test OTO - NOTNLM OT - Relative Energy Deficiency in Sport OT - low energy availability OT - resting metabolic rate EDAT- 2025/04/23 00:31 MHDA- 2025/06/12 18:26 CRDT- 2025/04/22 19:43 PHST- 2024/12/23 00:00 [received] PHST- 2025/02/23 00:00 [accepted] PHST- 2025/06/12 18:26 [medline] PHST- 2025/04/23 00:31 [pubmed] PHST- 2025/04/22 19:43 [entrez] AID - 10.1123/ijsnem.2024-0254 [doi] PST - epublish SO - Int J Sport Nutr Exerc Metab. 2025 Apr 22;35(4):324-336. doi: 10.1123/ijsnem.2024-0254. Print 2025 Jul 1. PMID- 40261703 OWN - NLM STAT- MEDLINE DCOM- 20250630 LR - 20250630 IS - 1538-005X (Electronic) IS - 0898-5669 (Linking) VI - 37 IP - 3 DP - 2025 Jul 1 TI - Intra and Inter-Rater Reliability and Convergent Validity of the Canadian Agility and Movement Skill Assessment (CAMSA) in Children With a Critical Congenital Heart Defect. PG - 327-334 LID - 10.1097/PEP.0000000000001200 [doi] AB - PURPOSE: This study determines the inter- and intra-rater reliability and convergent validity of the Canadian Agility and Movement Skill Assessment (CAMSA) for children with critical congenital heart disease (CCHD). METHODS: Forty-one children aged 7 to 10 with CCHD were recruited from the Wilhelmina Children's Hospital, Utrecht. The CAMSA and Movement-ABC-2 (M-ABC-2) were assessed concurrently. Four raters independently scored video recordings of the CAMSA at 2 moments at a 2-week interval. RESULTS: The inter- and intra-rater reliability of the CAMSA was excellent with an ICC of 0.94 and 0.95, respectively. A nonstatistically significant trend was found between the CAMSA and the M-ABC-2. CONCLUSIONS: The CAMSA is a reliable measurement for assessing complex motor skills in children aged 7 to 10 with CCHD. The convergent validity between the CAMSA and M-ABC-2 was nonsignificant suggesting these 2 tests measure different motor constructs. CI - Copyright (c) 2025 Academy of Pediatric Physical Therapy of the American Physical Therapy Association. FAU - Breeschooten, Yannick A D AU - Breeschooten YAD AD - Physical Therapy Sciences, Program in Clinical Health Sciences, University Medical Center Utrecht, Utrecht, The Netherlands (Ms Breeschooten); Child Development & Exercise Center, Wilhelmina Children's Hospital, UMC Utrecht, Utrecht, The Netherlands (Dr Noordstar, Dr Sprong, Ms de Kievit, Dr Takken, and Dr Hulzebos). FAU - Noordstar, Johannes J AU - Noordstar JJ FAU - Sprong, Maaike C A AU - Sprong MCA FAU - de Kievit, Anne AU - de Kievit A FAU - Takken, Tim AU - Takken T FAU - Hulzebos, Erik H J AU - Hulzebos EHJ LA - eng PT - Journal Article PT - Validation Study DEP - 20250627 PL - United States TA - Pediatr Phys Ther JT - Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association JID - 8912748 SB - IM MH - Humans MH - Male MH - Child MH - Reproducibility of Results MH - Female MH - *Heart Defects, Congenital/physiopathology/rehabilitation MH - *Motor Skills/physiology MH - Observer Variation MH - Canada MH - *Physical Therapy Modalities OTO - NOTNLM OT - congenital heart disease OT - motor skills OT - physical activity OT - reliability OT - validity COIS- The authors declare no conflict of interest. EDAT- 2025/04/22 16:27 MHDA- 2025/07/01 04:48 CRDT- 2025/04/22 12:02 PHST- 2025/07/01 04:48 [medline] PHST- 2025/04/22 16:27 [pubmed] PHST- 2025/04/22 12:02 [entrez] AID - 00001577-990000000-00162 [pii] AID - 10.1097/PEP.0000000000001200 [doi] PST - ppublish SO - Pediatr Phys Ther. 2025 Jul 1;37(3):327-334. doi: 10.1097/PEP.0000000000001200. Epub 2025 Jun 27. PMID- 40261052 OWN - NLM STAT- MEDLINE DCOM- 20250730 LR - 20260731 IS - 1537-6613 (Electronic) IS - 0022-1899 (Print) IS - 0022-1899 (Linking) VI - 232 IP - 1 DP - 2025 Jul 30 TI - Pharmacokinetic and Clinical Associations Between Doravirine-Containing Antiretroviral Therapy and Injectable and Implantable Hormonal Contraceptive Methods Among Women Living With Human Immunodeficiency Virus in South Africa. PG - 79-89 LID - 10.1093/infdis/jiaf196 [doi] AB - BACKGROUND: Drug resistance and intolerance of dolutegravir-containing antiretroviral therapy (ART) are rising in low- and middle-income countries, resulting in a potentially increased use of doravirine-containing ART use. There are knowledge gaps regarding doravirine and hormonal contraceptive drug-drug interactions among women living with human immunodeficiency virus (HIV). METHODS: We conducted a 5-parallel-group, prospective pharmacokinetic study among women living with HIV aged 18-45 years in Johannesburg, South Africa, between November 2021 and February 2024. We included a sixth, historical comparator group from a Kenyan study. After a >/=6-week lead-in period with doravirine-containing ART, participants initiated injectable medroxyprogesterone acetate (MPA), implantable etonogestrel (ENG), or nonhormonal intrauterine device contraception and were observed every 2-4 weeks for an additional 12 or 24 weeks. We analyzed serum MPA and ENG and plasma doravirine or dolutegravir concentrations per visit, using validated liquid chromatography-mass spectrometry assays. We assessed log-transformed concentrations of each drug with geometric mean ratios (90% confidence intervals) and a multivariate model adjusted for age and body mass index. We described safety, tolerability, and effectiveness (HIV RNA <40 copies/mL) of doravirine-containing ART. RESULTS: A total of 128 participants are included in this analysis. There were no significant reductions in the MPA, ENG, or doravirine concentrations. A total of 8 (3%) adverse events grade >/=2 were considered attributable to doravirine-containing ART and 22 (8%) to the contraceptive method. ART satisfaction was 100%, and viral suppression at study exit ranged from 86% to 96%. CONCLUSIONS: We found no detrimental bidirectional drug-drug interactions and few adverse events between doravirine and hormonal contraceptives. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Patel, Rena C AU - Patel RC AUID- ORCID: 0000-0001-9893-5856 AD - Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA. AD - Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA. FAU - Ndlovu, Nkosiphile AU - Ndlovu N AUID- ORCID: 0009-0008-3206-9666 AD - Faculty of Health Sciences, Wits RHI, University of the Witwatersrand, Johannesburg, South Africa. FAU - Maheria, Pooja AU - Maheria P AD - Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA. FAU - Kgoa, Reolebogile AU - Kgoa R AUID- ORCID: 0009-0006-5237-5885 AD - Faculty of Health Sciences, Wits RHI, University of the Witwatersrand, Johannesburg, South Africa. FAU - Kew, Lindsay AU - Kew L AD - Faculty of Health Sciences, Wits RHI, University of the Witwatersrand, Johannesburg, South Africa. FAU - Kapa, La-Donna AU - Kapa LD AD - Faculty of Health Sciences, Wits RHI, University of the Witwatersrand, Johannesburg, South Africa. FAU - Reddy, Krishnaveni AU - Reddy K AUID- ORCID: 0000-0002-3881-2704 AD - Faculty of Health Sciences, Wits RHI, University of the Witwatersrand, Johannesburg, South Africa. FAU - Govindasami, Merusha AU - Govindasami M AUID- ORCID: 0009-0001-1332-4333 AD - Faculty of Health Sciences, Wits RHI, University of the Witwatersrand, Johannesburg, South Africa. FAU - Matswake, Nomasonto AU - Matswake N AD - Faculty of Health Sciences, Wits RHI, University of the Witwatersrand, Johannesburg, South Africa. FAU - Sigcu, Nompumelelo AU - Sigcu N AUID- ORCID: 0009-0003-4203-6298 AD - Faculty of Health Sciences, Wits RHI, University of the Witwatersrand, Johannesburg, South Africa. FAU - Seedat, Mohammed AU - Seedat M AD - Faculty of Health Sciences, Wits RHI, University of the Witwatersrand, Johannesburg, South Africa. FAU - Shale, Lerato AU - Shale L AD - Faculty of Health Sciences, Wits RHI, University of the Witwatersrand, Johannesburg, South Africa. FAU - Yongo, Nashon AU - Yongo N AD - Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA. FAU - Hassan, Shukri A AU - Hassan SA AUID- ORCID: 0000-0001-6732-9263 AD - Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA. FAU - Williams, Tommy L AU - Williams TL AD - Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA. FAU - Erikson, David W AU - Erikson DW AUID- ORCID: 0000-0002-3383-9297 AD - Endocrine Technologies Core, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA. FAU - Scarsi, Kimberly K AU - Scarsi KK AUID- ORCID: 0000-0001-9406-693X AD - Department of Pharmacy Practice and Science; University of Nebraska Medical Center, Omaha, Nebraska, USA. FAU - Palanee-Phillips, Thesla AU - Palanee-Phillips T AUID- ORCID: 0000-0002-0052-5830 AD - Faculty of Health Sciences, Wits RHI, University of the Witwatersrand, Johannesburg, South Africa. AD - Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA. LA - eng GR - P51 OD011092/OD/NIH HHS/United States GR - P51 OD011092/CD/ODCDC CDC HHS/United States PT - Journal Article PL - United States TA - J Infect Dis JT - The Journal of infectious diseases JID - 0413675 RN - 0 (Pyridones) RN - 0 (Triazoles) RN - 0 (Piperazines) RN - 0 (Oxazines) RN - 0 (Heterocyclic Compounds, 3-Ring) RN - 81K9V7M3A3 (Desogestrel) RN - 0 (Anti-HIV Agents) RN - 0 (Anti-Retroviral Agents) RN - 0 (Contraceptive Agents, Hormonal) RN - DKO1W9H7M1 (Dolutegravir) RN - 913P6LK81M (doravirine) RN - 304GTH6RNH (etonogestrel) SB - IM MH - Humans MH - Female MH - Adult MH - *Pyridones/pharmacokinetics/therapeutic use/administration & dosage MH - *HIV Infections/drug therapy MH - South Africa MH - Prospective Studies MH - Middle Aged MH - Young Adult MH - *Triazoles/pharmacokinetics/therapeutic use/administration & dosage MH - Adolescent MH - Drug Interactions MH - Piperazines/pharmacokinetics MH - Oxazines/pharmacokinetics MH - Heterocyclic Compounds, 3-Ring/pharmacokinetics/blood MH - Desogestrel/pharmacokinetics/administration & dosage/blood MH - *Anti-HIV Agents/pharmacokinetics/therapeutic use MH - *Anti-Retroviral Agents/pharmacokinetics/therapeutic use MH - *Contraceptive Agents, Hormonal/pharmacokinetics/administration & dosage MH - Dolutegravir PMC - PMC12447852 MID - NIHMS2109030 OTO - NOTNLM OT - South Africa OT - doravirine-containing ART OT - drug-drug interactions OT - hormonal contraception OT - pharmacokinetic study COIS- Potential conflicts of interest. K. K. S. declares funding paid to her institution for investigator-initiated studies from Organon LLC and ViiV Healthcare. All other authors report no potential conflicts of interest. EDAT- 2025/04/22 16:27 MHDA- 2025/07/30 12:29 PMCR- 2026/07/30 CRDT- 2025/04/22 09:12 PHST- 2024/12/18 00:00 [received] PHST- 2025/04/11 00:00 [accepted] PHST- 2025/07/30 12:29 [medline] PHST- 2025/04/22 16:27 [pubmed] PHST- 2025/04/22 09:12 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - 8114927 [pii] AID - 10.1093/infdis/jiaf196 [doi] PST - ppublish SO - J Infect Dis. 2025 Jul 30;232(1):79-89. doi: 10.1093/infdis/jiaf196. PMID- 40259686 OWN - NLM STAT- MEDLINE DCOM- 20250609 LR - 20250609 IS - 2047-6310 (Electronic) IS - 2047-6302 (Linking) VI - 20 IP - 7 DP - 2025 Jul TI - Cross-sectional associations between Mediterranean diet and body composition in preschool children. CORAL study. PG - e70014 LID - 10.1111/ijpo.70014 [doi] AB - BACKGROUND: Overweight and obesity in children are rising globally, and the Mediterranean diet may help reduce obesity and related diseases. OBJECTIVE: To assess the association between adherence to the Mediterranean diet and body composition in Spanish preschool children. METHODS: This study included 1218 children aged 3-6 years from the CORALS cohort. Mediterranean diet adherence was evaluated using the validated MED4CHILD and COME-Kids F&B-FQ questionnaires. Body composition measurements included weight, height, waist circumference, BMI, Fat Mass (FM), Fat-Free Mass Index (FFMI), and Waist-to-Height ratio (WtHR). Multivariate regression and ANCOVA were used to examine associations, adjusting for factors like age, physical activity, and energy intake. We also performed a Cohen's d analysis to assess effect size. RESULTS: Adherence to the Mediterranean diet was associated with more favourable body composition in children. Specifically, both the MED4CHILD score and the COME-Kids-derived score showed significant associations with BMI, FFMI, and Waist-to-Height ratio, showing differences by sex. Children who adhered to the Mediterranean diet exhibited lower BMI and higher fat-free mass, and a more favourable waist-to-height ratio. Additionally, although some measures showed weaker associations, all analyses highlighted a trend towards improved body composition with higher adherence. Cohen's d analysis showed small to moderate effect sizes. CONCLUSION: Adherence to the Mediterranean diet was significantly linked to favorable body composition indices in Spanish children, highlighting the importance of promoting healthy dietary patterns to prevent overweight and obesity. CI - (c) 2025 World Obesity Federation. FAU - Larruy-Garcia, Alicia AU - Larruy-Garcia A AUID- ORCID: 0000-0002-2165-5263 AD - Growth, Exercise, Nutrition and Development (GENUD) Research Group, Instituto Agroalimentario de Aragon (IA2), Faculty of Health Sciences, Universidad de Zaragoza, Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. FAU - Miguel-Berges, Maria L AU - Miguel-Berges ML AUID- ORCID: 0000-0002-2411-9538 AD - Growth, Exercise, Nutrition and Development (GENUD) Research Group, Instituto Agroalimentario de Aragon (IA2), Faculty of Health Sciences, Universidad de Zaragoza, Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. AD - CIBER, Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. FAU - Torre, Isabel Rueda-De AU - Torre IR AUID- ORCID: 0009-0003-0586-0384 AD - Growth, Exercise, Nutrition and Development (GENUD) Research Group, Instituto Agroalimentario de Aragon (IA2), Faculty of Health Sciences, Universidad de Zaragoza, Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. AD - CIBER, Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. FAU - Pastor-Villaescusa, Belen AU - Pastor-Villaescusa B AUID- ORCID: 0000-0003-0817-6804 AD - Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), University of Cordoba, Cordoba, Spain. AD - Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS), RD21/0012/0008, Instituto de Salud Carlos III (ISCIII), Madrid, Spain. FAU - Leis, Rosaura AU - Leis R AUID- ORCID: 0000-0002-0540-4210 AD - CIBER, Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. AD - Instituto de Investigacion Sanitaria de Santiago (IDIS), Servicio de Neonatologia, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain. AD - Unit of Investigation in Nutrition, Growth and Human Development of Galicia, University of Santiago de Compostela, Santiago de Compostela, Spain. FAU - Babio, Nancy AU - Babio N AUID- ORCID: 0000-0003-3527-5277 AD - CIBER, Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. AD - Desenvolupament i Salut Mental ANUT-DSM, Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Alimentacio, Nutricio, Reus, Spain. AD - Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Unitat de Nutricio Humana, Reus, Spain. FAU - Navas-Carretero, Santiago AU - Navas-Carretero S AUID- ORCID: 0000-0002-5163-2230 AD - CIBER, Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. AD - Department of Nutrition Food Science & Physiology, University of Navarra, Pamplona, Spain. AD - Center for Nutrition Research, University of Navarra, Pamplona, Spain. AD - IdisNA, Navarra Institute for Health Research, Pamplona, Spain. FAU - Corella, Dolores AU - Corella D AUID- ORCID: 0000-0002-2366-4104 AD - Departament of Preventive Medicine and Public Health, Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, Valencia, Spain. FAU - Perez, Alejandra AU - Perez A AD - Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain. FAU - Gil-Campos, Mercedes AU - Gil-Campos M AUID- ORCID: 0000-0002-9007-0242 AD - CIBER, Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. AD - Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), University of Cordoba, Cordoba, Spain. FAU - Picans-Leis, Rosaura AU - Picans-Leis R AUID- ORCID: 0000-0003-4702-9962 AD - Instituto de Investigacion Sanitaria de Santiago (IDIS), Servicio de Neonatologia, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain. AD - Unit of Investigation in Nutrition, Growth and Human Development of Galicia, University of Santiago de Compostela, Santiago de Compostela, Spain. FAU - Garcia-Gavilan, Jesus AU - Garcia-Gavilan J AUID- ORCID: 0000-0002-3707-5255 AD - CIBER, Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. AD - Desenvolupament i Salut Mental ANUT-DSM, Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Alimentacio, Nutricio, Reus, Spain. AD - Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Unitat de Nutricio Humana, Reus, Spain. FAU - Flores-Barrante, Paloma AU - Flores-Barrante P AUID- ORCID: 0000-0002-2135-900X AD - Growth, Exercise, Nutrition and Development (GENUD) Research Group, Instituto Agroalimentario de Aragon (IA2), Faculty of Health Sciences, Universidad de Zaragoza, Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. FAU - Martinez, J Alfredo AU - Martinez JA AUID- ORCID: 0000-0001-5218-6941 AD - CIBER, Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. AD - Department of Nutrition Food Science & Physiology, University of Navarra, Pamplona, Spain. AD - Precision Nutrition and Cardiometabolic Health Program, IMDEA-Food Institute (Madrid Institute for Advanced Studies), CEI UAM + CSIC, Madrid, Spain. FAU - Llorente-Cantarero, Francisco Jesus AU - Llorente-Cantarero FJ AUID- ORCID: 0000-0003-0018-2011 AD - CIBER, Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. AD - Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), University of Cordoba, Cordoba, Spain. AD - Department of Specific Didactics, Faculty of Educational Sciences and Psychology, University of Cordoba, Cordoba, Spain. FAU - Vazquez-Cobela, Rocio AU - Vazquez-Cobela R AUID- ORCID: 0000-0002-3155-1601 AD - Instituto de Investigacion Sanitaria de Santiago (IDIS), Servicio de Neonatologia, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain. AD - Unit of Investigation in Nutrition, Growth and Human Development of Galicia, University of Santiago de Compostela, Santiago de Compostela, Spain. FAU - Paz-Graniel, Indira AU - Paz-Graniel I AUID- ORCID: 0000-0002-3204-6877 AD - CIBER, Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. AD - Desenvolupament i Salut Mental ANUT-DSM, Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Alimentacio, Nutricio, Reus, Spain. AD - Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Unitat de Nutricio Humana, Reus, Spain. FAU - Ayala-Marin, Aleli M AU - Ayala-Marin AM AUID- ORCID: 0000-0001-8914-0752 AD - Growth, Exercise, Nutrition and Development (GENUD) Research Group, Instituto Agroalimentario de Aragon (IA2), Faculty of Health Sciences, Universidad de Zaragoza, Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. FAU - Jurado-Castro, Jose Manuel AU - Jurado-Castro JM AUID- ORCID: 0000-0002-0198-2793 AD - CIBER, Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. AD - Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), University of Cordoba, Cordoba, Spain. FAU - de la Torre-Aguilar, Maria Jose AU - de la Torre-Aguilar MJ AUID- ORCID: 0000-0002-2473-0660 AD - Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), University of Cordoba, Cordoba, Spain. FAU - Gheorghita, Irina AU - Gheorghita I AUID- ORCID: 0000-0003-1222-4039 AD - Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Unitat de Nutricio Humana, Reus, Spain. AD - Pediatrics, Nutrition and development Research Unit (PediNuR), Universitat Rovira i Virgili, Reus, Spain. FAU - Moreno, Luis A AU - Moreno LA AUID- ORCID: 0000-0003-0454-653X AD - Growth, Exercise, Nutrition and Development (GENUD) Research Group, Instituto Agroalimentario de Aragon (IA2), Faculty of Health Sciences, Universidad de Zaragoza, Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. AD - CIBER, Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. FAU - De Miguel-Etayo, Pilar AU - De Miguel-Etayo P AUID- ORCID: 0000-0001-6173-5850 AD - Growth, Exercise, Nutrition and Development (GENUD) Research Group, Instituto Agroalimentario de Aragon (IA2), Faculty of Health Sciences, Universidad de Zaragoza, Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. AD - CIBER, Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. CN - CORAL Study group LA - eng PT - Journal Article DEP - 20250421 PL - England TA - Pediatr Obes JT - Pediatric obesity JID - 101572033 SB - IM MH - Humans MH - *Diet, Mediterranean/statistics & numerical data MH - Female MH - Male MH - Child, Preschool MH - Child MH - *Body Composition/physiology MH - Cross-Sectional Studies MH - Spain/epidemiology MH - *Pediatric Obesity/prevention & control/epidemiology MH - Body Mass Index OTO - NOTNLM OT - Mediterranean diet OT - body composition OT - body fat OT - preschool children FIR - Schroder, Helmut IR - Schroder H FIR - Moreira, Ana IR - Moreira A FIR - Fito, Montse IR - Fito M FIR - Perez-Vega, Karla A IR - Perez-Vega KA FIR - Baltodano, Mayela Solis IR - Baltodano MS FIR - Munoz-Aguayo, Daniel IR - Munoz-Aguayo D FIR - Blanchart, Gemma IR - Blanchart G FIR - Gaixas, Sonia IR - Gaixas S FIR - Zomeno, Maria Dolores IR - Zomeno MD FIR - Lorenzo, Isaury IR - Lorenzo I FIR - Gil-Campos, Mercedes IR - Gil-Campos M FIR - Jurado-Castro, Jose Manuel IR - Jurado-Castro JM FIR - Flores-Rojas, Katherine IR - Flores-Rojas K FIR - Villaescusa, Belen Pastor IR - Villaescusa BP FIR - Llorente-Cantarero, Francisco Jesus IR - Llorente-Cantarero FJ FIR - De La Torre-Aguilar, Maria Jose IR - De La Torre-Aguilar MJ FIR - Aguayo, Inmaculada Velasco IR - Aguayo IV FIR - Navas-Carretero, Santiago IR - Navas-Carretero S FIR - Martinez, J Alfredo IR - Martinez JA FIR - Moreno-Aliaga, Maria Jesus IR - Moreno-Aliaga MJ FIR - de Cuevillas Garcia, Begona IR - de Cuevillas Garcia B FIR - Goni, Maria IR - Goni M FIR - Hernandez, Maria IR - Hernandez M FIR - Diez, Salome Perez IR - Diez SP FIR - Cristobo, Carmen IR - Cristobo C FIR - Babio, Nancy IR - Babio N FIR - Salas-Salvado, Jordi IR - Salas-Salvado J FIR - Escribano, Joaquin IR - Escribano J FIR - Feliu, Albert IR - Feliu A FIR - Closas, Ricardo IR - Closas R FIR - Luque, Veronica IR - Luque V FIR - Ferre, Natalia IR - Ferre N FIR - Gheorghita, Irina IR - Gheorghita I FIR - Alcazar, Mireia IR - Alcazar M FIR - Martin, Francisco IR - Martin F FIR - Rey, Cristina IR - Rey C FIR - Mimbreros, Gisela IR - Mimbreros G FIR - Pedraza, Ana IR - Pedraza A FIR - Salvado, Olga IR - Salvado O FIR - Velasco, Marta Ruiz IR - Velasco MR FIR - Sustacha, Jose Angel Bilbao IR - Sustacha JAB FIR - Pinilla, Yolanda Herranz IR - Pinilla YH FIR - Rios, Lidia IR - Rios L FIR - Compte, Maria Pascual IR - Compte MP FIR - Garciduenas-Fimbres, Tany E IR - Garciduenas-Fimbres TE FIR - Gomez-Martinez, Carlos IR - Gomez-Martinez C FIR - de Sara, Las Heras-Delgado IR - de Sara LH FIR - Simon, Olga IR - Simon O FIR - de la Torre, Sonia IR - de la Torre S FIR - Tudela, Carol IR - Tudela C FIR - Sales, Julia Valero IR - Sales JV FIR - Garcia, Sara Morono IR - Garcia SM FIR - Leis, Rosaura IR - Leis R FIR - Lopez-Rubio, Alicia IR - Lopez-Rubio A FIR - Vazquez-Cobela, Rocio IR - Vazquez-Cobela R FIR - Picans-Leis, Rosaura IR - Picans-Leis R FIR - Portoles, Olga IR - Portoles O FIR - Franch, Pilar Codoner IR - Franch PC FIR - Corella, Dolores IR - Corella D FIR - Carbonell, Vanessa Martin IR - Carbonell VM FIR - Sorli, Jose V IR - Sorli JV FIR - Moreno, Luis A IR - Moreno LA FIR - De Miguel-Etayo, Pilar IR - De Miguel-Etayo P FIR - Santaliestra-Pasias, Alba M feminine IR - Santaliestra-Pasias AM FIR - Miguel-Berges, Maria Luisa IR - Miguel-Berges ML FIR - Argente-Arizon, Pilar IR - Argente-Arizon P FIR - Gimenez-Legarre, Natalia IR - Gimenez-Legarre N FIR - Flores-Barrantes, Paloma IR - Flores-Barrantes P FIR - Perez-Gimeno, Gloria IR - Perez-Gimeno G FIR - Seral-Cortes, Miguel IR - Seral-Cortes M FIR - Jimeno-Martinez, Andrea IR - Jimeno-Martinez A FIR - Maneschy, Ivie IR - Maneschy I EDAT- 2025/04/22 06:26 MHDA- 2025/06/09 06:26 CRDT- 2025/04/22 02:33 PHST- 2025/03/13 00:00 [revised] PHST- 2024/11/07 00:00 [received] PHST- 2025/03/31 00:00 [accepted] PHST- 2025/06/09 06:26 [medline] PHST- 2025/04/22 06:26 [pubmed] PHST- 2025/04/22 02:33 [entrez] AID - 10.1111/ijpo.70014 [doi] PST - ppublish SO - Pediatr Obes. 2025 Jul;20(7):e70014. doi: 10.1111/ijpo.70014. Epub 2025 Apr 21. PMID- 40259501 OWN - NLM STAT- MEDLINE DCOM- 20250422 LR - 20250425 IS - 1550-2783 (Electronic) IS - 1550-2783 (Linking) VI - 22 IP - 1 DP - 2025 Dec TI - Caregivers nutrition knowledge and perspectives on the enablers and barriers to nutrition provision for male academy football players. PG - 2495879 LID - 10.1080/15502783.2025.2495879 [doi] LID - 2495879 AB - BACKGROUND: The assessment of nutrition knowledge, alongside the enablers and barriers to optimal dietary intake, in youth football players has previously been documented. However, there is comparatively little research on either of these within parents or host families, which is of value to understand given the vital role that these stakeholders play as the primary food provider to young football players. Thus, the purpose of this study was to assess the nutrition knowledge of these caregivers and explore their perceptions of the barriers and enablers to nutrition provision for male academy football players. METHODS: A validated 35-item online questionnaire (A-NSKQ) was completed by 30 parents and 31 host family providers of youth academy football players from 16 different professional football clubs in England. The questionnaire consisted of 35 questions (total), 11 of which focussed on the assessment of general nutrition knowledge (GNK) and the remaining 24 assessed sports nutrition knowledge (SNK). Scores are presented as a percentage for total and each sub-section (GNK & SNK) and classified by the following rating: "poor" (0-49%); "average" (50-65%); "good" (66-75%); and "excellent" knowledge (76-100%). Differences in Total, GNK and SNK were compared between parents and host families using Independent-samples t-tests, with the alpha value set at p < 0.05 for all tests. A series of focus groups was also conducted with six parents and twelve host family representatives from four clubs to explore their perspectives of the enablers and barriers to providing nutrition support to youth football players. Thematic analysis was used to interpret the data. RESULTS: Host family providers demonstrated significantly better total nutrition knowledge than Parents (49.95 +/- 11.64% vs. p = 42.67 +/- 14.43%; p = 0.035), although the knowledge of both groups is classed as "poor." For the sub-sections of GNK & SNK, GNK was considered "average" and significantly better than SNK, which was classed as "poor" (GNK = 58.12 +/- 16.87% vs. SNK = 40.98 +/- 14.91%; p < 0.001). Host family providers reported significantly better SNK than parents (44.89 +/- 13.21% vs. 36.94 +/- 15.69%; p = 0.037) whilst no significant differences were observed in GNK between groups (61.00 +/- 15.07% vs. 55.15 +/- 18.33%; p = 0.180). Three key themes were generated relating to the caregivers' perceptions of the barriers and enablers to their food provision: 1) Club Support and Communication; 2) Time and Financial Resources; 3) Player-specific Characteristics. CONCLUSIONS: These findings suggest a clear need for football clubs to educate caregivers in the fundamental principles of healthy nutrition and football-specific nutrition requirements and encourage clubs to develop initiatives to better support caregivers in helping to young players to meet their dietary requirements. FAU - Cole, Matthew AU - Cole M AUID- ORCID: 0000-0001-9046-2505 AD - Hartpury University, Department of Sport, Hartpury, Gloucestershire, UK. FAU - Carter, Jennie L AU - Carter JL AD - Birmingham City University, Research Centre for Life and Sport Sciences (CLaSS), School of Health Sciences, Department of Sport and Exercise, Birmingham, West Midlands, UK. FAU - Brooks, Frances AU - Brooks F AD - Birmingham City University, Research Centre for Life and Sport Sciences (CLaSS), School of Health Sciences, Department of Sport and Exercise, Birmingham, West Midlands, UK. FAU - Roberts, Charlie J AU - Roberts CJ AD - Birmingham City University, Research Centre for Life and Sport Sciences (CLaSS), School of Health Sciences, Department of Sport and Exercise, Birmingham, West Midlands, UK. LA - eng PT - Journal Article DEP - 20250421 PL - United States TA - J Int Soc Sports Nutr JT - Journal of the International Society of Sports Nutrition JID - 101234168 SB - IM MH - Humans MH - Male MH - *Health Knowledge, Attitudes, Practice MH - *Soccer MH - Surveys and Questionnaires MH - Adolescent MH - *Parents/psychology MH - England MH - *Caregivers MH - Adult MH - *Sports Nutritional Physiological Phenomena MH - Female MH - Athletes MH - Sports Nutritional Sciences PMC - PMC12016246 OTO - NOTNLM OT - Youth soccer, nutrition support, nutrition provision OT - host families OT - parents COIS- No potential conflict of interest was reported by the author(s). EDAT- 2025/04/22 06:26 MHDA- 2025/04/22 06:27 PMCR- 2025/04/21 CRDT- 2025/04/22 00:43 PHST- 2025/04/22 06:27 [medline] PHST- 2025/04/22 06:26 [pubmed] PHST- 2025/04/22 00:43 [entrez] PHST- 2025/04/21 00:00 [pmc-release] AID - 2495879 [pii] AID - 10.1080/15502783.2025.2495879 [doi] PST - ppublish SO - J Int Soc Sports Nutr. 2025 Dec;22(1):2495879. doi: 10.1080/15502783.2025.2495879. Epub 2025 Apr 21. PMID- 40259343 OWN - NLM STAT- MEDLINE DCOM- 20250422 LR - 20250424 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Apr 21 TI - Validation of two body scales for assessment of thin-ideal and muscularity-ideal body dissatisfaction among Chinese adult females. PG - 1465 LID - 10.1186/s12889-025-22546-1 [doi] LID - 1465 AB - BACKGROUND: Previous studies have demonstrated the significant impact of body dissatisfaction on the physical and mental well-being of women. China's culture idealizes thinness and beauty, and women are more prone to experiencing body dissatisfaction. However, research on women's body dissatisfaction has predominantly focused on Western societies, with limited investigations conducted in China. Meanwhile, there exists a dearth of specific measurement tools for assessing Chinese adult women's body dissatisfaction. Therefore, the work aimed to assess the reliability of the Female Body Scale (FBS) and the Female Fit Body Scale (FFITBS) among Chinese adult women. METHODS: A total of 1,340 Chinese adult women selected body figures that most accurately represented their current and ideal bodies through the FBS and the FFITBS. Eating Disorder Examination Questionnaire 6.0 (EDE-Q6.0) and Drive for Muscularity Scale (DMS) were completed. Re-test was conducted four to 3-4 weeks later to complete the FBS and the FFITBS again. RESULTS: The validity and reliability of the FBS and the FFITBS have been demonstrated in Chinese adult women. A majority of women expressed a desire for a smaller body, which encompassed muscularity and adiposity dimensions. There was a significant correlation between body dissatisfaction scores and eating disorder scores among Chinese adult women. Additionally, the body dissatisfaction scores obtained from the FFITBS significantly predicted the DMS scores. Furthermore, among Chinese adult women, only the heterosexual and bisexual groups show differences in muscularity-dimension body dissatisfaction, while no significant differences are found among the other groups. CONCLUSIONS: The findings suggested that the FBS and the FFITBS could be valuable scientific tools for evaluating body dissatisfaction among Chinese adult women. CI - (c) 2025. The Author(s). FAU - Dou, Guangbo AU - Dou G AD - College of Exercise and Health, Shenyang Sport University, Liaoning, China. douguangbo@lnu.edu.cn. FAU - Wu, Jiahao AU - Wu J AD - College of Exercise and Health, Shenyang Sport University, Liaoning, China. FAU - Sun, Siyao AU - Sun S AD - College of Exercise and Health, Shenyang Sport University, Liaoning, China. LA - eng GR - LJ132410176014/Scientific Research Funding Project of Liaoning Provincial Department of Education-Basic Research Project ./ GR - LJ132410176014/Scientific Research Funding Project of Liaoning Provincial Department of Education-Basic Research Project ./ GR - LJ132410176014/Scientific Research Funding Project of Liaoning Provincial Department of Education-Basic Research Project ./ PT - Journal Article PT - Validation Study DEP - 20250421 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - Chinese people SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Middle Aged MH - Young Adult MH - *Body Dissatisfaction/psychology MH - *Body Image/psychology MH - China MH - Psychometrics MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - *Thinness/psychology MH - *East Asian People/psychology PMC - PMC12010662 OTO - NOTNLM OT - Body dissatisfaction OT - Drive for muscularity OT - Eating disorders OT - Muscularity-ideal OT - Sexual minorities OT - Thin-ideal OT - Thin-muscularity-ideal COIS- Declarations. Ethics approval and consent to participate: This work-involving human participants were in accordance with the ethical standards of Shenyang Sport University, with approval number 202407, and participants gave written consent prior to participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/04/22 00:26 MHDA- 2025/04/22 06:26 PMCR- 2025/04/21 CRDT- 2025/04/21 23:38 PHST- 2024/04/03 00:00 [received] PHST- 2025/03/31 00:00 [accepted] PHST- 2025/04/22 06:26 [medline] PHST- 2025/04/22 00:26 [pubmed] PHST- 2025/04/21 23:38 [entrez] PHST- 2025/04/21 00:00 [pmc-release] AID - 10.1186/s12889-025-22546-1 [pii] AID - 22546 [pii] AID - 10.1186/s12889-025-22546-1 [doi] PST - epublish SO - BMC Public Health. 2025 Apr 21;25(1):1465. doi: 10.1186/s12889-025-22546-1. PMID- 40257354 OWN - NLM STAT- MEDLINE DCOM- 20250609 LR - 20250609 IS - 1466-447X (Electronic) IS - 0264-0414 (Linking) VI - 43 IP - 13 DP - 2025 Jul TI - A comprehensive analysis of one-foot and two-foot approach jump reliability in youth basketball athletes. PG - 1267-1277 LID - 10.1080/02640414.2025.2493015 [doi] AB - The study assessed the intra-week reliability of the one-foot or two-foot approach jumps within youth basketball athletes. In a test-retest design, 108 athletes (33 females and 75 males) performed a maximal jump reach height assessment using both jump strategies following a self-selected run-up. Data were collected using the Vertec system across two sessions, separated by >24 hours and within <7 days. Results were analysed for bias and differences between tests, focussing on absolute (SEM) and relative (ICC) reliability; with statistical significance set at p < 0.05. No significant differences were found between test days for one-foot (female: -0.35 cm and male: -0.84 cm, p > 0.05) or two-foot (female: -0.24 cm and male: -0.15 cm, p > 0.05) jumps. Both tests displayed excellent reliability for both sexes (ICC = 0.99) and low SEM in the one-foot (female: 2.36 [1.93-3.17] cm and male: 2.33 [2.07-2.86] cm) and two-foot (female: 1.42 [1.14-1.87] cm and male: 2.38 [2.07-2.86] cm) approach jump. Females averaged 2.1 cm higher within the two-foot jump compared with the one-foot jump (p = 0.005). Smaller differences between test types were observed for the male athletes (-0.79 cm, p = 0.054) both of which were lower than the associated SEM and likely not significantly meaningful. Overall, the results indicate that the assessment of one-foot or two-foot approach jumps demonstrated excellent reliability in both female and male youth basketball athletes. FAU - Heels, Angus G AU - Heels AG AUID- ORCID: 0009-0000-3978-1594 AD - Precision Sport Science, Redwood City, CA, USA. FAU - Leahey, Samuel R AU - Leahey SR AUID- ORCID: 0009-0006-2651-4220 AD - Precision Sport Science, Redwood City, CA, USA. FAU - Laffer, Jason C AU - Laffer JC AUID- ORCID: 0009-0008-5688-9749 AD - Precision Sport Science, Redwood City, CA, USA. FAU - Chua, Kelvin Y H AU - Chua KYH AUID- ORCID: 0000-0003-1870-5634 AD - Precision Sport Science, Redwood City, CA, USA. FAU - Evans, Mackenzie C AU - Evans MC AUID- ORCID: 0009-0006-1518-1432 AD - Precision Sport Science, Redwood City, CA, USA. FAU - Whitworth-Turner, Craig M AU - Whitworth-Turner CM AUID- ORCID: 0000-0003-3975-0696 AD - Precision Sport Science, Redwood City, CA, USA. AD - Department of Kinesiology, Seattle University, Seattle, Washington, USA. FAU - Wannouch, Youssef J AU - Wannouch YJ AUID- ORCID: 0000-0003-1052-6535 AD - Precision Sport Science, Redwood City, CA, USA. LA - eng PT - Journal Article DEP - 20250421 PL - England TA - J Sports Sci JT - Journal of sports sciences JID - 8405364 SB - IM MH - Humans MH - *Basketball/physiology MH - Male MH - Female MH - Reproducibility of Results MH - Adolescent MH - *Exercise Test/methods MH - *Athletic Performance/physiology MH - *Plyometric Exercise/methods MH - Child MH - Foot/physiology OTO - NOTNLM OT - Performance OT - Vertec OT - adolescent athletes OT - repeated measures EDAT- 2025/04/21 12:29 MHDA- 2025/06/09 06:26 CRDT- 2025/04/21 09:52 PHST- 2025/06/09 06:26 [medline] PHST- 2025/04/21 12:29 [pubmed] PHST- 2025/04/21 09:52 [entrez] AID - 10.1080/02640414.2025.2493015 [doi] PST - ppublish SO - J Sports Sci. 2025 Jul;43(13):1267-1277. doi: 10.1080/02640414.2025.2493015. Epub 2025 Apr 21. PMID- 40257124 OWN - NLM STAT- MEDLINE DCOM- 20250609 LR - 20260903 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 28 IP - 1 DP - 2025 Apr 21 TI - Prediction of fat-free mass and fat mass from bioimpedance spectroscopy and anthropometry: a validation study in 7- to 9-year-old Kuwaiti children. PG - e95 LID - 10.1017/S1368980025000503 [doi] LID - e95 AB - OBJECTIVE: Childhood obesity is increasing in many countries, including Kuwait. Currently, adiposity is most commonly assessed from simple anthropometric measurements, e.g. height and weight or combined as body mass index (BMI). This is despite these surrogate measurements being poor indices of adiposity. Bioelectrical impedance analysis (BIA) is a popular method for the assessment of body composition providing a measurement of adiposity as absolute fat mass (FM) or FM expressed as a percentage of body weight (%BF). BIA is, however, an indirect predictive method. This study developed a BIA-based prediction equation for body composition assessment in Kuwaiti children and, additionally, a prediction equation for %BF based on sum of skin-fold (SSF) thickness measurements. DESIGN: A cross-sectional design was used with primary school recruitment. SETTING: School population in Kuwait City; in-clinic assessments. PARTICIPANTS: 158 Kuwaiti children aged 7-9 years. Body composition assessed using bioimpedance spectroscopy and skin-folds with prediction equations generate against deuterium dilution measurement of total body water and fat-free mass (FFM) as reference. RESULTS: The newly developed and cross-validated BIA equation predicted FFM with minimal bias (< 1%) and acceptable 2 sd limits of agreement (+/-1.6 kg equivalent to +/-10%) improving on the predictive performance of comparable published equations. Similarly, SSF predicted %BF with small bias (0.2 %BF) but relatively wide limits of agreement (+/-7 %BF). CONCLUSIONS: These new equations are suitable for practical use for nutritional assessment in Kuwaiti children, particularly in epidemiological or public health settings although their applicability in other populations requires further research. FAU - Al-Ati, Tareq AU - Al-Ati T AD - Food and Nutrition Program, Environment and Life Sciences Research Center, Kuwait Institute for Scientific Research, P.O. Box 24885, Safat13109, Kuwait. FAU - Wells, Jonathan AU - Wells J AD - Childhood Nutrition Research Centre, UCL Institute of Child Health, London, UK. FAU - Ward, Leigh C AU - Ward LC AUID- ORCID: 0000-0003-2378-279X AD - School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Brisbane, QLD4072, Australia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250421 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Child MH - Kuwait MH - Cross-Sectional Studies MH - *Electric Impedance MH - Male MH - Female MH - *Body Composition MH - Skinfold Thickness MH - *Anthropometry/methods MH - Body Mass Index MH - *Adipose Tissue MH - *Adiposity PMC - PMC12171910 OTO - NOTNLM OT - Bioelectrical impedance analysis (BIA) OT - Body composition analysis OT - Children OT - Deuterium dilution OT - Fat-free mass OT - Kuwait OT - Percentage body fat OT - Sum of skin-folds OT - Total body water COIS- Author L.C.W provides consultancy services to ImpediMed Ltd. ImpediMed Ltd. had no involvement in the conception and execution of this study or in the preparation of the manuscript. All other authors declare no conflict of interest. EDAT- 2025/04/21 12:28 MHDA- 2025/06/09 06:26 PMCR- 2025/04/21 CRDT- 2025/04/21 08:13 PHST- 2025/06/09 06:26 [medline] PHST- 2025/04/21 12:28 [pubmed] PHST- 2025/04/21 08:13 [entrez] PHST- 2025/04/21 00:00 [pmc-release] AID - S1368980025000503 [pii] AID - 10.1017/S1368980025000503 [doi] PST - epublish SO - Public Health Nutr. 2025 Apr 21;28(1):e95. doi: 10.1017/S1368980025000503. PMID- 40255502 OWN - NLM STAT- MEDLINE DCOM- 20250421 LR - 20250728 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 16 DP - 2025 TI - Obstructive sleep apnea syndrome in polycystic ovary syndrome: a systematic review and meta-analysis. PG - 1532519 LID - 10.3389/fendo.2025.1532519 [doi] LID - 1532519 AB - BACKGROUND: Polycystic ovary syndrome (PCOS) has been associated with a high prevalence of obstructive sleep apnea syndrome (OSAS). However, the impact of OSAS on the PCOS symptom profile remains unclear. This systematic review and meta-analysis, which informed the 2023 International Evidence-based PCOS Guideline, aims to assess the prevalence and related symptoms of OSAS among females with and without PCOS. METHODS: A systematic search using databases (MEDLINE, Embase, EBM Reviews, PsycInfo and CINAHL) was performed until 16(th) May 2024. Random-effects restricted maximum likelihood meta-analyses compared OSAS and related symptoms between PCOS and non-PCOS groups. OSAS outcomes were categorized as apnea-hypopnea index (AHI)>/=5 only, AHI>/=5 with symptoms, AHI>/=10 with symptoms and composite OSA (i.e., all AHI cut-offs with and/or without symptoms). Subgroup analyses by body mass index (BMI), age, PCOS diagnostic criteria and ethnicity were performed. Risk of bias and certainty of evidence by the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) framework were conducted. RESULTS: From 4438 records, 3205 titles/abstracts were screened and 40 were eligible for full-text screening. Eight cross-sectional studies met inclusion criteria and meta-analysis. The pooled prevalence of OSA was 37.0% in PCOS (29.0% adolescents; 40.0% adults) and 6.0% in non-PCOS. Compared with non-PCOS, those with PCOS showed higher risk for composite OSA (odds ratio (OR): 9.52; 95% CI: 3.90 to 23.26; I (2) = 54.5%; 8 studies, n=942; P<0.001) and more pronounced OSAS risk with increasing symptom severity in PCOS (AHI>/=5 OR: 3.90; 95% CI: 1.63 to 9.34; AHI>/=5 with symptoms OR: 17.95; 95% CI: 6.17 to 52.22; AHI>/=10 with symptoms OR: 30.61; 95% CI: 7.99 to 117.25, all P 25), smoking status, and race. We examined individual markers by trimester, changes in marker levels between trimesters, and ratios of pro- to anti-inflammatory markers, adjusting analyses for maternal age, gestational age, and fetal sex. RESULTS: First-trimester levels of proinflammatory cytokines (GM-CSF, IFN-alpha, IFN-gamma, IL-1alpha, IL-1beta, IL-8, IL-12p70, IL-17a, TNF-alpha) and anti-inflammatory cytokines (IL-4, IL-10, and IL-13) were strongly associated with preeclampsia (standardized odds ratios > 2). First-trimester pro-anti-inflammatory ratios (e.g. TNF-alpha:IL-10 and IFN-gamma:IL-10) also correlated with preeclampsia. Changes in inflammatory markers across trimesters and interactions with fetal sex were not significant. CONCLUSION: Our results suggest that the first trimester inflammatory markers and ratios may offer utility for preeclampsia prediction. Future research should explore these associations in diverse populations and validate their clinical utility. Early risk identification can inform interventions to prevent preeclampsia and improve perinatal outcomes. FAU - Jancsura, McKenzie K AU - Jancsura MK AUID- ORCID: 0000-0002-0654-7539 AD - Martha S. Pitzer Center for Women, Children and Youth, College of Nursing, The Ohio State University, Columbus, USA. FAU - Helsabeck, Nathan P AU - Helsabeck NP AUID- ORCID: 0000-0002-6883-9684 AD - College of Nursing, The Ohio State University, Columbus, USA. FAU - Anderson, Cindy M AU - Anderson CM AD - Martha S. Pitzer Center for Women, Children and Youth, College of Nursing, The Ohio State University, Columbus, USA. FAU - Conley, Yvette P AU - Conley YP AUID- ORCID: 0000-0002-1784-6067 AD - School of Nursing, University of Pittsburgh, Pittsburgh, USA. FAU - Hubel, Carl A AU - Hubel CA AD - Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, USA. AD - Magee-Womens Research Institute, Pittsbugh, USA. FAU - Roberts, James M AU - Roberts JM AD - Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, USA. AD - Magee-Womens Research Institute, Pittsbugh, USA. AD - Department of Endocrinology, School of Medicne, University of Pittsburgh, Pittsburgh, USA. AD - Department of Clinical and Translational Research, School of Medicine, University of Pittsburgh, Pittsburgh, USA. LA - eng GR - P01 HD030367/HD/NICHD NIH HHS/United States GR - T32 NR009759/NR/NINR NIH HHS/United States PT - Journal Article DEP - 20250417 PL - England TA - Hypertens Pregnancy JT - Hypertension in pregnancy JID - 9421297 RN - 0 (Biomarkers) RN - 0 (Cytokines) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Pre-Eclampsia/blood/diagnosis MH - Biomarkers/blood MH - Adult MH - *Cytokines/blood MH - *Obesity/blood/complications MH - Pregnancy Trimester, First/blood MH - Case-Control Studies MH - *Inflammation/blood MH - Young Adult PMC - PMC12079614 MID - NIHMS2074788 OTO - NOTNLM OT - Preeclampsia OT - biomarkers OT - inflammatory markers OT - obesity OT - prediction COIS- Competing interests: The authors have no conflicts of interest to report. EDAT- 2025/04/18 06:25 MHDA- 2025/04/18 06:26 PMCR- 2026/12/01 CRDT- 2025/04/18 00:22 PHST- 2025/04/18 06:26 [medline] PHST- 2025/04/18 06:25 [pubmed] PHST- 2025/04/18 00:22 [entrez] PHST- 2026/12/01 00:00 [pmc-release] AID - 10.1080/10641955.2025.2492084 [doi] PST - ppublish SO - Hypertens Pregnancy. 2025 Dec;44(1):2492084. doi: 10.1080/10641955.2025.2492084. Epub 2025 Apr 17. PMID- 40239195 OWN - NLM STAT- MEDLINE DCOM- 20250416 LR - 20260729 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 14 DP - 2025 Apr 16 TI - Calibration and Validation of Machine Learning Models for Physical Behavior Characterization: Protocol and Methods for the Free-Living Physical Activity in Youth (FLPAY) Study. PG - e65968 LID - 10.2196/65968 [doi] LID - e65968 AB - BACKGROUND: Wearable activity monitors are increasingly used to characterize physical behavior. The development and validation of these characterization methods require criterion-labeled data typically collected in a laboratory or simulated free-living environment, which does not generally translate well to free-living due to limited behavior engagement in development that is not representative of free living. OBJECTIVE: The Free-Living Physical Activity in Youth (FLPAY) study was designed in 2 parts to establish a criterion dataset for novel method development for identifying periods of transition between activities in youth. METHODS: The FLPAY study used criterion measures of behavior (direct observation) and energy expenditure (indirect calorimetry) to label data from research-grade accelerometer-based devices for the purpose of developing and cross-validating models to identify transitions, classify activity type, and estimate energy expenditure in youth aged 6-18 years. The first part of this study was a simulated free-living protocol in the laboratory, comprising short (roughly 60-90 s) and long (roughly 4-5 min) bouts of 16 activities that were completed in various orders over the span of 2 visits. The second part of this study involved an independent sample of participants who agreed to be measured twice (2 hours each time) in free-living environments such as the home and community. RESULTS: The FLPAY study was funded from 2016 to 2020. A no-cost extension was granted for 2021. A few secondary outcomes have been published, but extensive analysis of primary data is ongoing. CONCLUSIONS: The 2-part design of the FLPAY study emphasized the collection of naturalistic behaviors and periods of transition between activities in both structured and unstructured environments. This filled an important gap, considering the traditional focus on scripted activity routines in structured laboratory environments. This protocol paper details the FLPAY procedures and participants, along with details about criterion datasets, which will be useful in future studies analyzing the wealth of device-based data in diverse ways. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR1-10.2196/65968. CI - (c)Samuel Robert LaMunion, Paul Robert Hibbing, Scott Edward Crouter. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 16.04.2025. FAU - LaMunion, Samuel Robert AU - LaMunion SR AUID- ORCID: 0000-0002-7290-5189 AD - Diabetes, Endocrinology, and Obesity Branch - Energy Metabolism Section, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States. AD - Department of Kinesiology, Recreation, and Sports Studies, The University of Tennessee Knoxville, Knoxville, TN, United States. FAU - Hibbing, Paul Robert AU - Hibbing PR AUID- ORCID: 0000-0002-1469-5160 AD - Department of Kinesiology, Recreation, and Sports Studies, The University of Tennessee Knoxville, Knoxville, TN, United States. AD - Department of Kinesiology and Nutrition, The University of Illinois Chicago, Chicago, IL, United States. FAU - Crouter, Scott Edward AU - Crouter SE AUID- ORCID: 0000-0003-1297-9538 AD - Department of Kinesiology, Recreation, and Sports Studies, The University of Tennessee Knoxville, Knoxville, TN, United States. LA - eng GR - R01 HD083431/HD/NICHD NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Validation Study DEP - 20250416 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - *Exercise/physiology MH - Adolescent MH - Child MH - Male MH - Female MH - Energy Metabolism/physiology MH - Accelerometry/methods/instrumentation MH - *Machine Learning MH - Calibration MH - Calorimetry, Indirect/methods PMC - PMC12044308 OTO - NOTNLM OT - activity monitoring OT - criterion dataset OT - digital health OT - physical behavior assessment OT - physical behavior characterization OT - wearable devices OT - youth activity COIS- Conflicts of Interest: PRH has received funding from ActiGraph LLC. This study predates said funding, representing no conflict of interest. The authors have no conflicts of interest to report. EDAT- 2025/04/16 18:24 MHDA- 2025/04/16 18:25 PMCR- 2025/04/16 CRDT- 2025/04/16 16:53 PHST- 2024/09/03 00:00 [received] PHST- 2025/03/20 00:00 [accepted] PHST- 2025/02/03 00:00 [revised] PHST- 2025/04/16 18:25 [medline] PHST- 2025/04/16 18:24 [pubmed] PHST- 2025/04/16 16:53 [entrez] PHST- 2025/04/16 00:00 [pmc-release] AID - v14i1e65968 [pii] AID - 10.2196/65968 [doi] PST - epublish SO - JMIR Res Protoc. 2025 Apr 16;14:e65968. doi: 10.2196/65968. PMID- 40238530 OWN - NLM STAT- MEDLINE DCOM- 20250416 LR - 20260803 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 22 IP - 3 DP - 2025 Mar 13 TI - Developing a Novel Index for Individual-Level Social Determinants and Cardiovascular Diseases in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. LID - 10.3390/ijerph22030422 [doi] LID - 422 AB - BACKGROUND: Social determinants of health (SDH) have been found to contribute to cardiovascular risk and the development of cardiovascular disease (CVD). However, few studies have examined early-life exposure to SDH and the combined effect of multiple SDH measures on CVD. There is an urgent need to develop an SDH index for use in practice and clinical settings. METHODS: A total of 3189 participants from the CARDIA Study who had chest CT scans at the year-25 (Y25) visit were included in this study. Personal and parental SDH measures, including education, occupation, income, financial strain, and childhood family environment, were obtained through interviews. The participants' coronary artery calcification (CAC) was measured using chest CT scans, and left-ventricular mass (LVM) was measured using M-mode echocardiography. The values of the individual social determinants of health (iSDH) index were determined based on individual-level measures and CAC using a supervised learning method-the Boosted Regression Tree (BRT) model. This index's association with the LVM index (LVMI) was evaluated as an external validation using linear regression models adjusting for race, sex, BMI, smoking status, alcohol intake, and physical activity. RESULTS: Each one-standard-deviation (SD) increase in the iSDH index was associated with an increase in LVMI ranging from 0.376 (95% CI -0.016, 0.767) at year 0 to 0.468 (95% CI 0.115, 0.821) at year 20. The association between the iSDH index and the LVMI was more pronounced as the participants aged. Also, the iSDH indices were more strongly associated with LVMI among Black participants (beta = 0.969, 95% CI = 0.081, 1.858) than White participants (beta = 0.202, 95% CI = -0.228, 0.633) at year 5. CONCLUSIONS: Higher iSDH indices in early adulthood were associated with increased LVMI values in midlife. The association between the iSDH index and CVD was stronger among Black adults than with White adults. FAU - Gao, Tao AU - Gao T AD - Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. AD - Center for Global Oncology, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. FAU - Zheng, Yinan AU - Zheng Y AD - Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. AD - Center for Global Oncology, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. FAU - Joyce, Brian AU - Joyce B AUID- ORCID: 0000-0002-5271-6161 AD - Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. AD - Center for Global Oncology, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. FAU - Liu, Lei AU - Liu L AD - Division of Biostatistics, Washington University in St. Louis, St. Louis, MO 63110, USA. FAU - Liu, Lili AU - Liu L AD - Division of Biostatistics, Washington University in St. Louis, St. Louis, MO 63110, USA. FAU - Kiefe, Catarina AU - Kiefe C AUID- ORCID: 0000-0001-8719-6963 AD - Department of Population and Quantitative Health Sciences, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA. FAU - Forrester, Sarah AU - Forrester S AD - Department of Population and Quantitative Health Sciences, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA. FAU - Yu, Bing AU - Yu B AUID- ORCID: 0000-0003-4818-1077 AD - Department of Epidemiology and Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. FAU - Bhatt, Ankeet AU - Bhatt A AD - Division of Research, Kaiser Permanente San Francisco Medical Center, San Francisco, CA 94588, USA. FAU - Gordon-Larsen, Penny AU - Gordon-Larsen P AD - Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. FAU - Lloyd-Jones, Donald AU - Lloyd-Jones D AD - Preventive Medicine & Epidemiology Section, and Framingham Center for Population & Prevention Science, Boston University School of Medicine, Boston, MA 02118, USA. FAU - Zhang, Kai AU - Zhang K AD - Department of Population and Community Health, College of Public Health, The University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA. FAU - Hou, Lifang AU - Hou L AD - Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. AD - Center for Global Oncology, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. LA - eng GR - U01 AG088658/AG/NIA NIH HHS/United States GR - R01 HL143885/HL/NHLBI NIH HHS/United States GR - 75N92023D00004/HL/NHLBI NIH HHS/United States GR - R01 AG069120/AG/NIA NIH HHS/United States GR - R01AG069120, R01AG081244/AG/NIA NIH HHS/United States GR - 17SFRN33700278, 14SFRN20790000/American Heart Association/ GR - 75N92023D00002, 75N92023D00005/University of Alabama at Birmingham/ GR - 75N92023D00002/HL/NHLBI NIH HHS/United States GR - 75N92023D00003/HL/NHLBI NIH HHS/United States GR - 75N92023D00006/HL/NHLBI NIH HHS/United States GR - R01 AG081244/AG/NIA NIH HHS/United States GR - 75N92023D00005/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20250313 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - Male MH - Female MH - *Social Determinants of Health MH - Adult MH - *Coronary Artery Disease/epidemiology MH - *Cardiovascular Diseases/epidemiology MH - Young Adult MH - Risk Factors MH - United States/epidemiology MH - Middle Aged MH - Tomography, X-Ray Computed PMC - PMC11942548 OTO - NOTNLM OT - coronary artery calcification OT - left ventricular mass OT - social determinants of health COIS- The authors declare no conflicts of interest. EDAT- 2025/04/16 18:24 MHDA- 2025/04/16 18:25 PMCR- 2025/03/13 CRDT- 2025/04/16 12:25 PHST- 2025/02/17 00:00 [received] PHST- 2025/03/10 00:00 [revised] PHST- 2025/03/11 00:00 [accepted] PHST- 2025/04/16 18:25 [medline] PHST- 2025/04/16 18:24 [pubmed] PHST- 2025/04/16 12:25 [entrez] PHST- 2025/03/13 00:00 [pmc-release] AID - ijerph22030422 [pii] AID - ijerph-22-00422 [pii] AID - 10.3390/ijerph22030422 [doi] PST - epublish SO - Int J Environ Res Public Health. 2025 Mar 13;22(3):422. doi: 10.3390/ijerph22030422. PMID- 40238504 OWN - NLM STAT- MEDLINE DCOM- 20250416 LR - 20260803 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 22 IP - 3 DP - 2025 Mar 13 TI - Assessing Aquatic Readiness as a Health-Enhancing Measure in Young Swimmers with Physical Disabilities: The Revised Aquatic Independence Measure (AIM-2). LID - 10.3390/ijerph22030421 [doi] LID - 421 AB - Based on the well-established health outcomes associated with the aquatic environment, this study aimed to evaluate the validity of the Aquatic Independence Measure-Revised (AIM-2). The original scale comprised twenty-three skills, graded on a five-point proficiency scale. A sample of one hundred eight young swimmers with disabilities, who had completed at least two years of training, was assessed by their coaches, generating a dataset of four thousand nine hundred sixty-eight scores. Exploratory factor analysis (EFA) and internal consistency measures were applied to validate the scale's structure, resulting in the extraction of three factors accounting for sixty-four percent of the variance, based on thirteen original items. Two independent experts established interrater reliability in twenty-two participants. Additionally, divergent validity was examined across participants' years of swim-training experience across three disability severity categories, gender, and two age groups. Significant differences were found in skill acquisition based on years of experience and disability severity. The results indicate that the AIM-2 effectively assesses swimming readiness in young swimmers with disabilities. Coaches can use it to monitor progress, optimize training, and support the health benefits of aquatic activities for children and adolescents with disabilities. FAU - Chacham-Guber, Anat AU - Chacham-Guber A AD - Israel ParaSport Center, Ramat-Gan 5253529, Israel. FAU - Sapir, Yadin AU - Sapir Y AUID- ORCID: 0009-0005-0670-9744 AD - Israel ParaSport Center, Ramat-Gan 5253529, Israel. AD - The Exercise Physiology Program, School of Public Health, Faculty for Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel. FAU - Goral, Aviva AU - Goral A AD - Levinsky-Wingate Academic College, Faculty for Movement and Sports Sciences, Wingate Institute, Netanya 4290200, Israel. FAU - Hutzler, Yeshayahu AU - Hutzler Y AUID- ORCID: 0000-0003-1955-5500 AD - Israel ParaSport Center, Ramat-Gan 5253529, Israel. AD - Levinsky-Wingate Academic College, Faculty for Movement and Sports Sciences, Wingate Institute, Netanya 4290200, Israel. LA - eng PT - Journal Article DEP - 20250313 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - Female MH - Male MH - *Swimming MH - Adolescent MH - Child MH - *Persons with Disabilities MH - Reproducibility of Results PMC - PMC11942436 OTO - NOTNLM OT - learn to swim OT - motor function OT - motor tests OT - physical disability OT - training COIS- The authors A.C.-G., Y.S. and Y.H. were employed by the non-profit organization "Israel Parasport Center". A.G. declares that this research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest. EDAT- 2025/04/16 18:24 MHDA- 2025/04/16 18:25 PMCR- 2025/03/13 CRDT- 2025/04/16 12:24 PHST- 2025/01/19 00:00 [received] PHST- 2025/03/04 00:00 [revised] PHST- 2025/03/08 00:00 [accepted] PHST- 2025/04/16 18:25 [medline] PHST- 2025/04/16 18:24 [pubmed] PHST- 2025/04/16 12:24 [entrez] PHST- 2025/03/13 00:00 [pmc-release] AID - ijerph22030421 [pii] AID - ijerph-22-00421 [pii] AID - 10.3390/ijerph22030421 [doi] PST - epublish SO - Int J Environ Res Public Health. 2025 Mar 13;22(3):421. doi: 10.3390/ijerph22030421. PMID- 40237129 OWN - NLM STAT- MEDLINE DCOM- 20250704 LR - 20260824 IS - 1098-108X (Electronic) IS - 0276-3478 (Linking) VI - 58 IP - 7 DP - 2025 Jul TI - Cross-Cultural Validation and Application of the EDE-Q 6.0 for Screening and Assessment of Eating Disorders in Chinese Females. PG - 1319-1331 LID - 10.1002/eat.24439 [doi] AB - OBJECTIVE: This study aims to evaluate the cross-cultural validity and utility of the Chinese version of the Eating Disorder Examination Questionnaire 6.0 (EDE-Q 6.0) as a screening and assessment tool for eating disorders (EDs) among Chinese females. METHOD: Participants included 652 female patients diagnosed with EDs and 311 healthy female controls, with data collected from five separate research projects conducted between 2018 and 2024. Receiver operating characteristic (ROC) curve analysis determined diagnostic accuracy and optimal cut-off scores. Correlation analyses, Wilcoxon signed-rank tests, and regression analyses were used to evaluate the relationship between changes in EDE-Q 6.0 scores and other clinical measures following treatment in 55 patients with anorexia nervosa (AN) and 74 patients with bulimia nervosa (BN). RESULTS: The Chinese version of the EDE-Q 6.0 demonstrated strong diagnostic accuracy in distinguishing EDs from the healthy population, with an optimal cut-off global score of 2.54 (area under ROC curve = 88.5%, sensitivity = 77.5%, specificity = 91.8%), significantly higher than in previous reports. Changes in EDE-Q 6.0 scores significantly correlated with clinical measures such as BMI, binge-eating frequency, Beck Depression Inventory, Beck Anxiety Inventory, and Eating Disorder Inventory subscales in both patients with AN and patients with BN (p < 0.05). Wilcoxon tests and stepwise regression confirmed its validity in reflecting clinical changes, capturing symptom variability related to BMI and depression in AN (p < 0.01) and binge-eating frequency and body dissatisfaction in BN (p < 0.01). CONCLUSION: The Chinese version of the EDE-Q 6.0 is a valid and effective screening and assessment tool for EDs in Chinese females. The updated cut-off score, now closer to international standards, reflects progress in the cultural adaptation of the tool and a potential shift in acceptance to report psychological problems among Chinese patients. CI - (c) 2025 Wiley Periodicals LLC. FAU - Gu, Lian AU - Gu L AUID- ORCID: 0000-0002-3699-8250 AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Zhou, Bubu AU - Zhou B AUID- ORCID: 0009-0006-8302-0622 AD - Department of Psychology, The University of Hong Kong, Pokfulam, Hong Kong. FAU - Peng, Sufang AU - Peng S AUID- ORCID: 0000-0003-2680-9687 AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Chen, Han AU - Chen H AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Kang, Qing AU - Kang Q AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Chen, Jue AU - Chen J AUID- ORCID: 0000-0002-9924-2573 AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. LA - eng GR - GWVI-11.2-YQ39/Shanghai 3-year action plan to strengthen the construction of public health system-Outstanding Young Talents Project/ GR - 20224Y0267/Youth Project of Shanghai Health Commission/ GR - SHDC12023122/Clinical Science and Technology Innovation Project of Shanghai Hospital Development Center/ GR - 82071545/National Natural Science Foundation of China/ GR - 2023-TX-019/Shanghai Mental Health Center Hospital-Level Project/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250416 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM MH - Humans MH - Female MH - Adult MH - China MH - *Feeding and Eating Disorders/diagnosis MH - Cross-Cultural Comparison MH - Young Adult MH - Psychometrics MH - Reproducibility of Results MH - Surveys and Questionnaires MH - Adolescent MH - *Psychiatric Status Rating Scales/standards MH - Bulimia Nervosa/diagnosis MH - Anorexia Nervosa/diagnosis MH - Sensitivity and Specificity OTO - NOTNLM OT - Chinese females OT - EDE-Q 6.0 OT - anorexia nervosa OT - bulimia nervosa OT - cross-cultural OT - eating disorders OT - screening and assessment EDAT- 2025/04/16 14:35 MHDA- 2025/07/04 12:42 CRDT- 2025/04/16 06:12 PHST- 2025/03/29 00:00 [revised] PHST- 2024/11/26 00:00 [received] PHST- 2025/03/29 00:00 [accepted] PHST- 2025/07/04 12:42 [medline] PHST- 2025/04/16 14:35 [pubmed] PHST- 2025/04/16 06:12 [entrez] AID - 10.1002/eat.24439 [doi] PST - ppublish SO - Int J Eat Disord. 2025 Jul;58(7):1319-1331. doi: 10.1002/eat.24439. Epub 2025 Apr 16. PMID- 40236324 OWN - NLM STAT- MEDLINE DCOM- 20250416 LR - 20250417 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Food neophobia among university students in Saudi Arabia: a cross-sectional survey of prevalence and predictor analysis. PG - 1571899 LID - 10.3389/fpubh.2025.1571899 [doi] LID - 1571899 AB - INTRODUCTION: Due to the absence of scientific information on food neophobia (i.e., fear or reluctance to try new or unfamiliar foods) among young adults in Saudi Arabia, the aim of this study was to assess the prevalence and predictors of food neophobia in Saudi university students. METHODS: This cross-sectional study included 480 students from two public universities of Saudi Arabia. The data was collected via an internet-based structured questionnaire. Participants' sociodemographic, health and behavioral information were included as explanatory variables (15 variables). Participants' food neophobia was assessed using a10-item validated food neophobia scale. A logistic regression model was fitted to find out the predictors of food neophobia. RESULTS: Approximately half of the participants (49.6%) exhibited food neophobia. Participants who engaged in regular physical exercise had a lower risk of developing food neophobia than their counterparts (AOR: 0.43, 95%CI: 0.20-0.92). Participants with food allergies (AOR: 4.36, 95%CI: 2.73-6.94) and disordered eating attitudes (AOR: 2.52, 95%CI: 1.27-5.02) and who took dietary supplements (AOR: 6.76, 95%CI: 3.54-12.90) were more likely to be food neophobic. Moreover, participants' preferences for fish and sea food (r(s) = -0.150), milk and dairy products (r(s) = -0.309,), chocolate and candies (r(s) = -0.329) and snacks, chips, and nuts (r(s) = -0.166) were significantly correlated with food neophobia. CONCLUSION: A higher level of food neophobia was observed among surveyed university students in Saudi Arabia. Several factors, such as regular physical exercise, food allergies, dietary supplement consumption, and disordered eating attitudes, were found to be associated with food neophobia. To provide empirical evidence on food neophobia, additional research with large and representative samples could be performed in other regions of Saudi Arabia. CI - Copyright (c) 2025 Alshahrani. FAU - Alshahrani, Najim Z AU - Alshahrani NZ AD - Department of Family and Community Medicine, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia. LA - eng PT - Journal Article DEP - 20250401 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Cross-Sectional Studies MH - *Students/psychology/statistics & numerical data MH - Female MH - Male MH - Universities MH - Young Adult MH - Prevalence MH - Surveys and Questionnaires MH - Adult MH - Adolescent MH - *Food Preferences/psychology PMC - PMC11996773 OTO - NOTNLM OT - eating disorder OT - eating habits OT - food neophobia OT - food preference OT - students COIS- The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/04/16 06:19 MHDA- 2025/04/16 06:20 PMCR- 2025/04/01 CRDT- 2025/04/16 05:24 PHST- 2025/02/10 00:00 [received] PHST- 2025/03/21 00:00 [accepted] PHST- 2025/04/16 06:20 [medline] PHST- 2025/04/16 06:19 [pubmed] PHST- 2025/04/16 05:24 [entrez] PHST- 2025/04/01 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1571899 [doi] PST - epublish SO - Front Public Health. 2025 Apr 1;13:1571899. doi: 10.3389/fpubh.2025.1571899. eCollection 2025. PMID- 40233463 OWN - NLM STAT- MEDLINE DCOM- 20250516 LR - 20250728 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 135 DP - 2025 Jul TI - Turkish validity and reliability of the Four Facet Mindful Eating Scale (FFaMES-TR) in adolescence. PG - 112770 LID - S0899-9007(25)00088-7 [pii] LID - 10.1016/j.nut.2025.112770 [doi] AB - OBJECTIVES: The aim of this study was to evaluate the validity and reliability of the Four Facet Mindful Eating Scale by Carriere et al. in a Turkish adolescent group. METHODS: The study included 591 participants between 14 and 17 years old. The Cronbach's alpha (CA) coefficient was used to evaluate the internal consistency reliability and the test-retest method was applied. Exploratory factor analysis (EFA) was performed to determine the factor structure. The model obtained with EFA was evaluated with confirmatory factor analysis. RESULTS: The total CA of the scale was 0.893, non-reactance CA 0.898, external awareness 0.808, non-judgment 0.862, internal awareness 0.772. The relationships between the total score and subscales in the first test and retest were found to be significant (P < 0.001). The Kaiser-Meyer-Olkin value was 0.903. Bartlett's test of sphericity, the correlation level between the items was found to be sufficient for factor analysis (chi;2 = 5326.27, standard deviation = 231, P = 0.001; P < 0.05). The factor loadings of the items were between 0.511 and 0.885, and the factors explained 61.8% of the variance. It was observed that the model had an acceptable fit (chi(2)/standard deviation 3.035, comparative fit index 0.933, Tucker-Lewis index 0.904, standardized root mean square error 0.057, and root mean square error of approximation 0.058. Because of applying EFA to the 29 questions in the scale, it was decided to remove 8 items from the final scale. CONCLUSIONS: The Turkish version of the Four Facet Mindful Eating Scale is valid and reliable for assessing mindful eating behaviors among adolescents. CI - Copyright (c) 2025 Elsevier Inc. All rights reserved. FAU - Akcadag, Neslihan Surmeli AU - Akcadag NS AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Yuzuncu Yil University, Van, Tusba, Turkiye. Electronic address: nessurmeli@gmail.com. FAU - Bilici, Saniye AU - Bilici S AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Emek, Ankara, Turkiye. LA - eng PT - Journal Article PT - Validation Study DEP - 20250317 PL - United States TA - Nutrition JT - Nutrition (Burbank, Los Angeles County, Calif.) JID - 8802712 SB - IM MH - Humans MH - Adolescent MH - Reproducibility of Results MH - Turkey MH - Female MH - Male MH - Factor Analysis, Statistical MH - Surveys and Questionnaires/standards MH - *Feeding Behavior/psychology MH - *Mindfulness MH - Psychometrics MH - *Adolescent Behavior/psychology OTO - NOTNLM OT - Adolescence OT - Mindful eating OT - Mindfulness OT - Validity and reliability COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article. EDAT- 2025/04/16 00:24 MHDA- 2025/05/17 17:03 CRDT- 2025/04/15 18:02 PHST- 2024/11/17 00:00 [received] PHST- 2025/03/04 00:00 [revised] PHST- 2025/03/13 00:00 [accepted] PHST- 2025/05/17 17:03 [medline] PHST- 2025/04/16 00:24 [pubmed] PHST- 2025/04/15 18:02 [entrez] AID - S0899-9007(25)00088-7 [pii] AID - 10.1016/j.nut.2025.112770 [doi] PST - ppublish SO - Nutrition. 2025 Jul;135:112770. doi: 10.1016/j.nut.2025.112770. Epub 2025 Mar 17. PMID- 40233006 OWN - NLM STAT- MEDLINE DCOM- 20250521 LR - 20260813 IS - 1935-5548 (Electronic) IS - 0149-5992 (Print) IS - 0149-5992 (Linking) VI - 48 IP - 6 DP - 2025 Jun 1 TI - Islet Autoantibodies and Their Association With beta-Cell Function and Diabetes Measures in Children With Acute Recurrent and Chronic Pancreatitis. PG - 974-981 LID - 10.2337/dc24-2672 [doi] AB - OBJECTIVE: In children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP), circulating islet autoantibodies (auto-Ab) may influence beta-cell function. This study reports Ab prevalence in youth with ARP or CP and investigates effects on indices of insulin secretion during mixed meal tolerance testing (MMTT) and diabetes status. RESEARCH DESIGN AND METHODS: This was a retrospective cross-sectional analysis of 234 youth with ARP or CP who had islet Ab testing (Ab+ group, n = 28 [12%]; Ab- group, n = 206 [88%]). Fasting glucose and HbA1c were collected. MMTT was performed in 78% of participants (183 of 234). MMTT-derived indices were calculated and compared between groups. RESULTS: The Ab+ and Ab- groups did not differ in age, sex, race, ethnicity, BMI percentile, or fasting glucose. Of Ab+ patients, 54% had one Ab+ islet and 46% had multiple Ab+ islets. Comparing the Ab+ to Ab- groups, HbA1c was higher (median 5.7 vs. 5.2%, P < 0.01), and C-peptide was lower (median 2.4 vs. 3.7 ng/mL, P = 0.01) in the Ab+ group. The Ab+ compared with the Ab- group had a higher proportion of prediabetes/diabetes (57% vs. 32%, P < 0.001). In survival analysis, the Ab+ group had significantly shorter time from first acute pancreatitis episode to diabetes development (P = 0.02). CONCLUSIONS: In children with ARP or CP, Ab+ was associated with higher risk of diabetes/diabetes development and shorter time to diabetes development, suggesting that islet Ab+ is associated with beta-cell dysfunction in this patient cohort. Islet Ab+ was also associated with higher HbA1c and lower C-peptide levels. Future studies are needed to validate the role of islet Ab positivity in pancreatitis. CI - (c) 2025 by the American Diabetes Association. FAU - Ginzburg, Gila AU - Ginzburg G AUID- ORCID: 0009-0007-5211-4105 AD - Medical College of Wisconsin and Children's Wisconsin, Milwaukee, WI. FAU - Hornung, Lindsey AU - Hornung L AD - Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. FAU - Denson, Lee AU - Denson L AD - Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH. AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. FAU - Shah, Amy S AU - Shah AS AUID- ORCID: 0000-0001-7297-139X AD - Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH. AD - Division of Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. FAU - Swauger, Sarah AU - Swauger S AD - Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH. AD - Division of Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. FAU - Tatum, Jonathan AU - Tatum J AD - Division of Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. FAU - Tellez, Siobhan AU - Tellez S AUID- ORCID: 0000-0002-3631-0313 AD - Division of Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. FAU - Elder, Deborah AU - Elder D AUID- ORCID: 0000-0002-6417-3619 AD - Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH. AD - Division of Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. FAU - Bellin, Melena D AU - Bellin MD AUID- ORCID: 0000-0002-7324-4837 AD - Department of Pediatrics, Division of Pediatric Endocrinology, University of Minnesota Medical School, Minneapolis, MN. AD - Department of Surgery, Division of Pediatric Endocrinology, University of Minnesota Medical School, Minneapolis, MN. FAU - Abu-El-Haija, Maisam AU - Abu-El-Haija M AD - Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH. AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. LA - eng GR - R03 DK 131156/GF/NIH HHS/United States GR - R03 DK131156/DK/NIDDK NIH HHS/United States GR - NH/NIH HHS/United States GR - P30 DK078392/DK/NIDDK NIH HHS/United States GR - P30 DK078392/GF/NIH HHS/United States PT - Journal Article PL - United States TA - Diabetes Care JT - Diabetes care JID - 7805975 RN - 0 (Autoantibodies) RN - 0 (Glycated Hemoglobin) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - Male MH - Child MH - Female MH - *Autoantibodies/immunology/blood MH - Adolescent MH - *Insulin-Secreting Cells/immunology/metabolism MH - Cross-Sectional Studies MH - Retrospective Studies MH - *Pancreatitis/immunology/blood MH - *Pancreatitis, Chronic/immunology/blood MH - *Islets of Langerhans/immunology MH - Glycated Hemoglobin/metabolism MH - *Diabetes Mellitus/immunology MH - Blood Glucose/metabolism PMC - PMC12094204 COIS- Duality of Interest. M.D.B. discloses research support from Dexcom and Viacyte, and advisory board roles for Vertex, Novo Nordisk, Soleno, and BridgeBio. EDAT- 2025/04/15 18:24 MHDA- 2025/05/21 18:29 PMCR- 2026/06/01 CRDT- 2025/04/15 13:13 PHST- 2024/12/02 00:00 [received] PHST- 2025/03/13 00:00 [accepted] PHST- 2025/05/21 18:29 [medline] PHST- 2025/04/15 18:24 [pubmed] PHST- 2025/04/15 13:13 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - 158107 [pii] AID - dc242672 [pii] AID - 10.2337/dc24-2672 [doi] PST - ppublish SO - Diabetes Care. 2025 Jun 1;48(6):974-981. doi: 10.2337/dc24-2672. PMID- 40232261 OWN - NLM STAT- MEDLINE DCOM- 20250520 LR - 20260716 IS - 1875-8908 (Electronic) IS - 1387-2877 (Print) IS - 1387-2877 (Linking) VI - 105 IP - 2 DP - 2025 May TI - Psychometrics of the Lifetime Total Physical Activity Questionnaire in adults with a history of depression. PG - 666-676 LID - 10.1177/13872877251330323 [doi] AB - BackgroundDepression earlier in life is a risk factor for dementia later in life. Physical activity is associated with less risk of depression and dementia. However, prevention of Alzheimer's disease may be most effective before the onset of brain pathology, which precedes dementia symptoms by 20 + years, requiring the measure of physical activity across the life course.ObjectiveAssess the reliability and validity of the Lifetime Total Physical Activity Questionnaire (LTPAQ) in community-dwelling cognitively intact adults with and without a history of depression.MethodsTest-retest reliability was assessed with intraclass correlations (ICC). Evidence of construct validity was assessed with descriptive statistics using the contrasted group approach and a priori hypotheses testing with each intensity (sedentary, light, moderate, vigorous) within each domain (school/occupation, transportation, household, leisure-time) across the life course (school-age, adolescence, young adult, middle adult).ResultsEvidence of test-retest reliability and construct validity was found during school-age and adolescence for moderate school/occupation (ICC = 0.562, p = 0.006; ICC = 0.605, p = 0.003, respectively) and household (ICC = 0.945, p < 0.001; ICC = 0.829, p < 0.001, respectively); during young adulthood for moderate school/occupation (ICC = 0.844, p < 0.001), transportation (ICC = 0.747, p < 0.001), and household (ICC = 0.608, p = 0.002); and during middle adulthood for moderate transportation (ICC = 0.977, p < 0.001). At both time points, there were zero reported school-age vigorous school/occupation and household; adolescent vigorous transportation; young adult vigorous household; and middle adult vigorous transportation and household physical activity.ConclusionsThe LTPAQ may be used to examine physical activity across the life course and risk for Alzheimer's disease in community-dwelling cognitively intact adults with and without a history of depression. FAU - Torres, Elisa R AU - Torres ER AUID- ORCID: 0000-0003-0064-2540 AD - College of Nursing, Wayne State University, Detroit, MI, USA. FAU - Lopez-Lambert, Eloise M AU - Lopez-Lambert EM AUID- ORCID: 0000-0003-3016-7306 AD - School of Nursing, University of Mississippi Medical Center, Jackson, MS, USA. FAU - Bendlin, Barbara B AU - Bendlin BB AUID- ORCID: 0000-0002-0580-9875 AD - Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA. AD - Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA. AD - Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA. LA - eng GR - R01 AG037639/AG/NIA NIH HHS/United States GR - UL1 TR000427/TR/NCATS NIH HHS/United States GR - KL2 TR000428/TR/NCATS NIH HHS/United States GR - UL1 TR002373/TR/NCATS NIH HHS/United States GR - P30 AG072931/AG/NIA NIH HHS/United States GR - KL2 TR002374/TR/NCATS NIH HHS/United States GR - U54 GM115428/GM/NIGMS NIH HHS/United States GR - P50 AG033514/AG/NIA NIH HHS/United States GR - HHSN268201800014I/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20250415 PL - United States TA - J Alzheimers Dis JT - Journal of Alzheimer's disease : JAD JID - 9814863 SB - IM MH - Humans MH - Male MH - Female MH - *Exercise/psychology/physiology MH - Middle Aged MH - Surveys and Questionnaires MH - *Psychometrics MH - *Depression/psychology/diagnosis MH - Aged MH - Reproducibility of Results MH - Adult MH - Young Adult MH - Adolescent MH - Aged, 80 and over PMC - PMC12634049 MID - NIHMS2104462 OTO - NOTNLM OT - Alzheimer's disease OT - dementia OT - depression OT - exercise OT - reliability OT - validity COIS- Conflicting interestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Barbara Bendlin is an Editorial Board Member of this journal but was not involved in the peer-review process of this article nor had access to any information regarding its peer-review. The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/04/15 12:29 MHDA- 2025/05/20 06:28 PMCR- 2026/05/01 CRDT- 2025/04/15 10:43 PHST- 2025/05/20 06:28 [medline] PHST- 2025/04/15 12:29 [pubmed] PHST- 2025/04/15 10:43 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - 10.1177/13872877251330323 [doi] PST - ppublish SO - J Alzheimers Dis. 2025 May;105(2):666-676. doi: 10.1177/13872877251330323. Epub 2025 Apr 15. PMID- 40230089 OWN - NLM STAT- MEDLINE DCOM- 20260306 LR - 20260306 IS - 1941-0921 (Electronic) IS - 1941-7381 (Print) IS - 1941-0921 (Linking) VI - 18 IP - 2 DP - 2026 Mar-Apr TI - Normalization Methods for Shoulder Strength in Baseball Athletes. PG - 446-456 LID - 10.1177/19417381251329929 [doi] AB - BACKGROUND: Arm injuries in baseball continue to rise. Previous studies have confirmed relationships between shoulder strength, injury risk, and performance in baseball athletes. Shoulder strength measures vary considerably within and among baseball players and are influenced heavily by anthropometric measures. Presently, the normalization of shoulder strength measures has not been tested adequately to meet necessary statistical assumptions. HYPOTHESIS: At least 1 shoulder strength normalization method would meet 2 statistical assumptions: the intercept assumption and correlation assumption. STUDY DESIGN: Cross-sectional study. LEVEL OF EVIDENCE: Level 3. METHODS: Isometric shoulder strength was tested in a cohort of uninjured baseball athletes on the dominant limb via handheld dynamometry: external rotation (ER), internal rotation (IR), and scapular plane abduction (SCAP). Five normalization methods were assessed using 2 statistical assumptions to determine the most appropriate normalization method for each shoulder strength measure: first, the regression line between a participant characteristic (body mass, height, ulnar length, and their respective combinations) and the unnormalized strength measure passes through the origin; second, normalizing shoulder strength eliminates its correlation with the participant characteristics. Statistical significance was set a priori at alpha < 0.05. RESULTS: Body mass normalization was the only normalization method that satisfied the intercept and correlation assumptions for ER, IR, and SCAP strength (P > .05). CONCLUSION: Normalizing shoulder ER, IR, and SCAP strength in uninjured baseball athletes using body mass satisfied both statistical assumptions. When clinicians seek to compare shoulder strength in baseball athletes of differing anthropometric make-up, using body mass as the denominator is the most appropriate method for normalization. CLINICAL RELEVANCE: The utilization of a statistically supported shoulder strength normalization method is warranted to account for anthropometric differences when comparing strength between athletes. This study adds a clinically relevant and reproducible method for normalizing isometric shoulder strength in uninjured baseball players. FAU - Kennedy, Sean M AU - Kennedy SM AD - Memorial Hermann Health, Rockets Sports Medicine Institute, Houston, Texas. FAU - Myers, Natalie L AU - Myers NL AD - Memorial Hermann Health, Rockets Sports Medicine Institute, Houston, Texas. FAU - Conway, John E AU - Conway JE AD - University of Texas Health Sciences Center, McGovern School of Medicine, Houston, Texas. FAU - Garrison, J Craig AU - Garrison JC AD - Memorial Hermann Health, Rockets Sports Medicine Institute, Houston, Texas. FAU - Guffey, Thomas AU - Guffey T AD - Texas Woman's University, Houston, Texas. FAU - Bailey, Lane B AU - Bailey LB AD - Memorial Hermann Health, Rockets Sports Medicine Institute, Houston, Texas. FAU - Arnold, Amanda J AU - Arnold AJ AD - Memorial Hermann Health, Rockets Sports Medicine Institute, Houston, Texas. AD - Texas Woman's University, Houston, Texas. LA - eng PT - Journal Article DEP - 20250414 PL - United States TA - Sports Health JT - Sports health JID - 101518422 SB - IM MH - Humans MH - *Baseball/physiology/injuries MH - *Muscle Strength/physiology MH - Cross-Sectional Studies MH - *Shoulder/physiology MH - Male MH - Young Adult MH - Rotation MH - Muscle Strength Dynamometer MH - Body Mass Index MH - Adolescent MH - Adult PMC - PMC11999986 OTO - NOTNLM OT - baseball OT - normalization OT - shoulder OT - strength COIS- The following author declared potential conflicts of interest: J.E.C. has received payments from Arthrex, Pylant Medical, and MedInc of Texas. EDAT- 2025/04/15 06:23 MHDA- 2026/03/06 09:01 PMCR- 2026/04/14 CRDT- 2025/04/15 02:52 PHST- 2026/03/06 09:01 [medline] PHST- 2025/04/15 06:23 [pubmed] PHST- 2025/04/15 02:52 [entrez] PHST- 2026/04/14 00:00 [pmc-release] AID - 10.1177_19417381251329929 [pii] AID - 10.1177/19417381251329929 [doi] PST - ppublish SO - Sports Health. 2026 Mar-Apr;18(2):446-456. doi: 10.1177/19417381251329929. Epub 2025 Apr 14. PMID- 40229835 OWN - NLM STAT- MEDLINE DCOM- 20250415 LR - 20250417 IS - 2047-783X (Electronic) IS - 0949-2321 (Print) IS - 0949-2321 (Linking) VI - 30 IP - 1 DP - 2025 Apr 15 TI - Smartphone addiction and musculoskeletal associated disorders in university students: biomechanical measures and questionnaire survey analysis. PG - 274 LID - 10.1186/s40001-025-02413-w [doi] LID - 274 AB - BACKGROUND: Smartphone addiction significantly impacts the musculoskeletal system, with 79% of younger adults aged 18-44 reporting excessive cell phone use. In addition, rare data exist on the roles of biological markers like 5-HT receptors, oxidative stress markers (TAC, MDA), collagen biomarkers (TIMP-1, TIMP-2), and triglycerides (TG) in the effects of smartphone addiction on the musculoskeletal system, particularly among university students. OBJECTIVE: Thus, the study aimed to investigate the potential link between smartphone addiction levels and certain biological indicators related to musculoskeletal injuries in the hands and necks of young, healthy university students. METHODS: A total of 250 healthy university students aged 17-30 years old were randomly invited to participate in this descriptive cross-sectional analytical study. All participants were categorized into two groups based on their smartphone usage duration: non-addicted (1-3h./day; n = 48) and addicted (>/= 5h./day; n = 12). Smartphone addiction, musculoskeletal discomfort in the neck and hands, adiposity-related outcomes, and musculoskeletal disorder (MSD) biomarkers, like matrixmetalloproteinases (MMPs); TIMP-1,TIMP-2;5-hydroxytryptophans (5-HT), triglyceride (TG), malondialdehyde (MDA), and total antioxidant capacity (TAC) were assessed using validated questionnaires like the Neck Disability Index (NDI), Cornell Hand Discomfort Questionnaire (CHDQ), and Visual Analogue Scale (VAS), respectively, and ELISA immunoassay analysis. RESULTS: A significant link was reported between smartphone addiction and neck pain, hand discomfort, and adiposity markers in 64%of the participant cohort. Moreover, females exhibited higher rates of addiction and susceptibility compared to their male counterparts (62.5% vs. 37.5%). Overall, the outcomes score of prolonged smartphone usage was positively correlated with adiposity, musculoskeletal disorders, and pain measured by the NDI, CHDQ, and VAS, respectively. Smartphone-addicted students demonstrated lower levels of TIMP-1, TIMP-2, and TAC activity, along with elevated 5-HT, TG, and MDA levels, compared to non-addicted controls. CONCLUSION: Smartphone addiction is positively associated with adiposity and musculoskeletal issues, particularly in the neck, shoulders, and hands, among university students. Key biomarkers (TIMP-1, TIMP-2, 5-HT, TG, MDA, TAC) significantly correlate with the severity of neck and hand MSD, as indicated by NDI, CHDQ, and VAS scores. Thus, public health initiatives are essential to raise awareness of the physical and biological risks of excessive smartphone use. CI - (c) 2025. The Author(s). FAU - Alghadir, Ahmad H AU - Alghadir AH AD - Rehabilitation Research Chair, Department of Rehabilitation Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, 11433, Riyadh, Saudi Arabia. FAU - Gabr, Sami A AU - Gabr SA AD - Rehabilitation Research Chair, Department of Rehabilitation Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, 11433, Riyadh, Saudi Arabia. FAU - Rizk, Ashraf A AU - Rizk AA AD - Department of Biomechanics & Motor Behavior, College of Sport Sciences & Physical Activity, King Saud University, 11433, Riyadh, Saudi Arabia. FAU - Alghadir, Talal AU - Alghadir T AD - College of Medicine, King Saud University, 11433, Riyadh, Saudi Arabia. FAU - Alghadir, Faisal AU - Alghadir F AD - College of Medicine, King Saud University, 11433, Riyadh, Saudi Arabia. FAU - Iqbal, Amir AU - Iqbal A AD - Rehabilitation Research Chair, Department of Rehabilitation Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, 11433, Riyadh, Saudi Arabia. physioamir@gmail.com. LA - eng GR - RSP2024R382/Researchers Supporting Project number (RSP2024R382), King Saud University, Riyadh, Saudi Arabia/ PT - Journal Article DEP - 20250415 PL - England TA - Eur J Med Res JT - European journal of medical research JID - 9517857 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Male MH - Adult MH - *Smartphone MH - Young Adult MH - *Students MH - Adolescent MH - Universities MH - Cross-Sectional Studies MH - *Musculoskeletal Diseases/etiology/epidemiology MH - Surveys and Questionnaires MH - Biomarkers/blood MH - *Behavior, Addictive PMC - PMC11998459 OTO - NOTNLM OT - Adolescents OT - Biological markers OT - Musculoskeletal disorders OT - Pain OT - Smartphone addiction COIS- Declarations. Ethics statement and consent to participate: The study was performed between January and June 2022. The study protocol conformed to the ethical guidelines of the 1975 Declaration of Helsinki and was reviewed and approved by the Ethics Sub-Committee of King Saud University, Kingdom of Saudi Arabia, under file number ID: RRC-2022-028; dated: 15 January 2022. The study's objectives and intent were elucidated, and participants were provided with clear explanations. Subsequently, informed verbal consent was obtained from all the individuals involved. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/04/15 00:25 MHDA- 2025/04/15 06:24 PMCR- 2025/04/15 CRDT- 2025/04/14 23:40 PHST- 2024/08/05 00:00 [received] PHST- 2025/02/26 00:00 [accepted] PHST- 2025/04/15 06:24 [medline] PHST- 2025/04/15 00:25 [pubmed] PHST- 2025/04/14 23:40 [entrez] PHST- 2025/04/15 00:00 [pmc-release] AID - 10.1186/s40001-025-02413-w [pii] AID - 2413 [pii] AID - 10.1186/s40001-025-02413-w [doi] PST - epublish SO - Eur J Med Res. 2025 Apr 15;30(1):274. doi: 10.1186/s40001-025-02413-w. PMID- 40228820 OWN - NLM STAT- MEDLINE DCOM- 20251121 LR - 20251121 IS - 2047-4881 (Electronic) IS - 2047-4873 (Linking) VI - 32 IP - 10 DP - 2025 Aug 5 TI - Adverse pregnancy outcomes and risk of atrial fibrillation: findings from the HUNT study. PG - 845-854 LID - 10.1093/eurjpc/zwaf233 [doi] AB - AIMS: Despite well-studied associations between hypertensive disorders of pregnancy (HDP) and atrial fibrillation (AF), the mechanisms of the excess risk of AF in women with history of HDP are not fully understood. Furthermore, little is known about associations between other adverse pregnancy outcomes (APOs) and AF, including preterm birth, small/large-for-gestational-age (SGA/LGA) offspring. METHODS AND RESULTS: By linking the population-based HUNT study with the Medical Birth Registry of Norway (MBRN) and electronic patient administrative systems, 15 104 women >/=45 years with 34 674 births were followed and assessed for validated AF for a median of 12.9 years. Information on APOs was retrieved from the MBRN. We used Cox proportional hazards models to calculate hazard ratios (HRs) for associations of APOs with the risk of AF. By inverse odds ratio weighting, we assessed modifiable AF risk factors that could explain the associations. Among women aged 45-65, those with HDP had a higher risk of AF [HR 2.03, 95% confidence interval (CI) 1.27-3.24] as women without HDP, but not among women >65 years (HR 0.95, 95% CI 0.57-1.60). A history of LGA was associated with increased risk of AF (HR 1.38, 95% CI 1.03-1.84), but histories of preterm birth or SGA were not (HR 0.94, 95% CI 0.63-1.41, HR 0.90, 95% CI 0.66-1.23). Post-pregnancy body mass index might possibly explain approximately 45% of the associations between HDP or LGA and AF. CONCLUSION: Women with history of HDP or LGA offspring are at higher risk of AF. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of the European Society of Cardiology. FAU - Morooka, Hikaru AU - Morooka H AUID- ORCID: 0000-0003-0758-4988 AD - Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 8905, N-7491 Trondheim, Norway. AD - Department of Obstetrics and Gynecology, Levanger Hospital, Nord-Trondelag Hospital Trust, Kirkegata 2, 7600 Levanger, Norway. AD - Department of General Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, 02215 MA, USA. FAU - Haug, Eirin B AU - Haug EB AUID- ORCID: 0000-0001-8565-9151 AD - Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 8905, N-7491 Trondheim, Norway. FAU - Malmo, Vegard AU - Malmo V AUID- ORCID: 0000-0001-5954-7594 AD - Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 7491 Trondheim, Norway. AD - Clinic of Cardiology, St. Olavs University Hospital, Prinsesse Kristinas gate 3, 7030 Trondheim, Norway. FAU - Loennechen, Jan Pal AU - Loennechen JP AUID- ORCID: 0000-0003-0492-3286 AD - Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 7491 Trondheim, Norway. AD - Clinic of Cardiology, St. Olavs University Hospital, Prinsesse Kristinas gate 3, 7030 Trondheim, Norway. FAU - Ellekjaer, Hanne AU - Ellekjaer H AUID- ORCID: 0000-0002-2887-3722 AD - Department of Neuromedicine and Movement Science, NTNU-Norwegian University of Science and Technology, N-7491 Trondheim, Norway. AD - Stroke Unit, Department of Internal Medicine, St. Olavs University Hospital, Prinsesse Kristinas gate 3, 7030 Trondheim, Norway. FAU - Sen, Abhijit AU - Sen A AD - Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 8905, N-7491 Trondheim, Norway. AD - Center for Oral Health Services and Research (TkMidt), Professor Brochs gt. 2, 7030 Trondheim, Norway. FAU - Mukamal, Kenneth J AU - Mukamal KJ AUID- ORCID: 0000-0001-8450-6970 AD - Department of General Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, 02215 MA, USA. FAU - Rich-Edwards, Janet AU - Rich-Edwards J AUID- ORCID: 0000-0001-5066-8808 AD - Connors Center for Women's Health and Gender Biology, Division of Women's Health, Brigham and Women's Hospital, 75 Francis St, Boston, 02115 MA, USA. AD - Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, 02115 MA, USA. AD - Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, 02115 MA, USA. FAU - Janszky, Imre AU - Janszky I AD - Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 8905, N-7491 Trondheim, Norway. AD - Department of General Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, 02215 MA, USA. AD - Regional Center for Health Care Improvement, St. Olavs University Hospital, Prinsesse Kristinas gate 3, 7030 Trondheim, Norway. AD - Department of Global Public Health, Karolinska Institutet, Norrbackagatan 4, 171 76 Stockholm, Sweden. FAU - Horn, Julie AU - Horn J AUID- ORCID: 0000-0003-1344-9707 AD - Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 8905, N-7491 Trondheim, Norway. AD - Department of Obstetrics and Gynecology, Levanger Hospital, Nord-Trondelag Hospital Trust, Kirkegata 2, 7600 Levanger, Norway. LA - eng GR - Liaison Committee for Education/ GR - Research and Innovation in Central Norway/ PT - Journal Article PL - England TA - Eur J Prev Cardiol JT - European journal of preventive cardiology JID - 101564430 SB - IM CIN - Eur J Prev Cardiol. 2025 Aug 5;32(10):855-856. doi: 10.1093/eurjpc/zwaf326. PMID: 40519192 MH - Humans MH - Female MH - *Atrial Fibrillation/epidemiology/diagnosis MH - Pregnancy MH - Norway/epidemiology MH - Middle Aged MH - Risk Factors MH - Risk Assessment MH - Registries MH - *Pregnancy Outcome/epidemiology MH - *Hypertension, Pregnancy-Induced/epidemiology/diagnosis MH - Premature Birth/epidemiology MH - Infant, Newborn MH - Aged MH - Incidence MH - Time Factors MH - Infant, Small for Gestational Age OAB - Adverse pregnancy outcomes such as hypertensive disorders of pregnancy (HDP) are associated with a higher risk of cardiovascular disease (CVD) and atrial fibrillation (AF). However, there is limited evidence on the associations between preterm birth, small/large-for-gestational age (SGA/LGA) offspring and AF. We have investigated the association between HDP, preterm birth, SGA/LGA, and AF in the population-based cohort from Norway (the HUNT study) among women over 45 years old. We also assessed modifiable AF risk factors within the associations. Our findings reveal that history of HDP was associated with about 100% higher risk of AF among women aged 45-65, and history of LGA was associated with about 40% increased risk of AF among women aged over 45. OABL- eng OTO - NOTNLM OT - Adverse pregnancy outcomes OT - Atrial fibrillation OT - Epidemiology OT - HUNT OT - Hypertensive disorders of pregnancy OT - Large-for-gestational age OT - Preterm birth OT - Small-for-gestational age OT - Women's health COIS- Conflict of interest: None declared. EDAT- 2025/04/15 00:25 MHDA- 2025/11/21 06:27 CRDT- 2025/04/14 20:13 PHST- 2024/12/05 00:00 [received] PHST- 2025/01/02 00:00 [revised] PHST- 2025/04/05 00:00 [accepted] PHST- 2025/11/21 06:27 [medline] PHST- 2025/04/15 00:25 [pubmed] PHST- 2025/04/14 20:13 [entrez] AID - 8113286 [pii] AID - 10.1093/eurjpc/zwaf233 [doi] PST - ppublish SO - Eur J Prev Cardiol. 2025 Aug 5;32(10):845-854. doi: 10.1093/eurjpc/zwaf233. PMID- 40227492 OWN - NLM STAT- MEDLINE DCOM- 20250612 LR - 20250615 IS - 1617-7940 (Electronic) IS - 1617-7959 (Print) IS - 1617-7940 (Linking) VI - 24 IP - 3 DP - 2025 Jun TI - Femoral bone growth predictions based on personalized multi-scale simulations: validation and sensitivity analysis of a mechanobiological model. PG - 879-894 LID - 10.1007/s10237-025-01942-x [doi] AB - Musculoskeletal function is pivotal to long-term health. However, various patient groups develop torsional deformities, leading to clinical, functional problems. Understanding the interplay between movement pattern, bone loading and growth is crucial for improving the functional mobility of these patients and preserving long-term health. Multi-scale simulations in combination with a mechanobiological bone growth model have been used to estimate bone loads and predict femoral growth trends based on cross-sectional data. The lack of longitudinal data in the previous studies hindered refinements of the mechanobiological model and validation of subject-specific growth predictions, thereby limiting clinical applications. This study aimed to validate the growth predictions using magnetic resonance images and motion capture data-collected longitudinally-from ten growing children. Additionally, a sensitivity analysis was conducted to refine model parameters. A linear regression model based on physical activity information, anthropometric data and predictions from the refined mechanobiological model explained 70% of femoral anteversion development. Notably, the direction of femoral development was accurately predicted in 18 out of 20 femurs, suggesting that growth predictions could help to revolutionize treatment strategies for torsional deformities. CI - (c) 2025. The Author(s). FAU - Koller, Willi AU - Koller W AD - Department of Biomechanics, Kinesiology and Computer Science in Sport, Centre for Sport Science and University Sports, University of Vienna, Vienna, Austria. willi.koller@univie.ac.at. AD - Neuromechanics Research Group, Centre for Sport Science and University Sports, University of Vienna, Vienna, Austria. willi.koller@univie.ac.at. AD - Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences, University of Vienna, Vienna, Austria. willi.koller@univie.ac.at. FAU - Svehlik, Martin AU - Svehlik M AD - Department of Orthopedics and Traumatology, Medical University of Graz, Graz, Austria. FAU - Wallnofer, Elias AU - Wallnofer E AD - Department of Biomechanics, Kinesiology and Computer Science in Sport, Centre for Sport Science and University Sports, University of Vienna, Vienna, Austria. AD - Neuromechanics Research Group, Centre for Sport Science and University Sports, University of Vienna, Vienna, Austria. AD - Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences, University of Vienna, Vienna, Austria. FAU - Kranzl, Andreas AU - Kranzl A AD - Laboratory for Gait and Human Movements, Orthopaedic Hospital Speising, Vienna, Austria. AD - Vienna Bone and Growth Center, Vienna, Austria. FAU - Mindler, Gabriel AU - Mindler G AD - Department of Pediatric Orthopaedics, Orthopaedic Hospital Speising, Vienna, Austria. AD - Vienna Bone and Growth Center, Vienna, Austria. FAU - Baca, Arnold AU - Baca A AD - Department of Biomechanics, Kinesiology and Computer Science in Sport, Centre for Sport Science and University Sports, University of Vienna, Vienna, Austria. FAU - Kainz, Hans AU - Kainz H AD - Department of Biomechanics, Kinesiology and Computer Science in Sport, Centre for Sport Science and University Sports, University of Vienna, Vienna, Austria. AD - Neuromechanics Research Group, Centre for Sport Science and University Sports, University of Vienna, Vienna, Austria. LA - eng PT - Journal Article PT - Validation Study DEP - 20250414 PL - Germany TA - Biomech Model Mechanobiol JT - Biomechanics and modeling in mechanobiology JID - 101135325 SB - IM MH - Humans MH - *Femur/growth & development/diagnostic imaging/physiology MH - Child MH - Male MH - Biomechanical Phenomena MH - *Models, Biological MH - Female MH - *Bone Development/physiology MH - Magnetic Resonance Imaging MH - *Computer Simulation MH - Reproducibility of Results MH - Linear Models MH - Sensitivity and Specificity PMC - PMC12162800 OTO - NOTNLM OT - Femoral bone growth OT - Finite element analysis OT - Mechanobiological model validation OT - Musculoskeletal modelling OT - Semi-automated growth predictions COIS- Declarations. Conflict of interest: The authors declare no competing interests. EDAT- 2025/04/14 12:25 MHDA- 2025/06/12 12:32 PMCR- 2025/04/14 CRDT- 2025/04/14 11:16 PHST- 2024/09/10 00:00 [received] PHST- 2025/03/03 00:00 [accepted] PHST- 2025/06/12 12:32 [medline] PHST- 2025/04/14 12:25 [pubmed] PHST- 2025/04/14 11:16 [entrez] PHST- 2025/04/14 00:00 [pmc-release] AID - 10.1007/s10237-025-01942-x [pii] AID - 1942 [pii] AID - 10.1007/s10237-025-01942-x [doi] PST - ppublish SO - Biomech Model Mechanobiol. 2025 Jun;24(3):879-894. doi: 10.1007/s10237-025-01942-x. Epub 2025 Apr 14. PMID- 40227137 OWN - NLM STAT- MEDLINE DCOM- 20250506 LR - 20250506 IS - 1466-447X (Electronic) IS - 0264-0414 (Linking) VI - 43 IP - 11 DP - 2025 Jun TI - Validation of polar verity sense for heart rate monitoring during school-based high-intensity interval training in adolescents. PG - 1076-1084 LID - 10.1080/02640414.2025.2491163 [doi] AB - The polar verity sense (PVS) is a user-friendly heart rate monitoring tool for field-based research compared to Polar H10. However, its validity in the real world (e.g., school settings) among children and adolescents is yet to be determined. Thirty-nine adolescents (12.2 +/- 0.4 years, 25 males) participated in a 6-min resistance-based high-intensity interval training (HIIT) session. Heart rate was simultaneously measured by PVS and Polar H10 (criterion measure). Validation metrics included within-participant correlation, mean absolute error, mean absolute percentage error and Bland-Altman plots. Overall, PVS showed very strong within-participant correlation (r = 0.93, p < .001) with Polar H10. The mean absolute and percentage error was 4 b.min-1 and 2.8%, respectively. The correlation between PVS and Polar H10 decreased (r = 0.84, p < .001) for data above the HIIT intensity threshold (>/=80% maximal heart rate) but maintained a strong relationship. The validity of PVS remained similar when accounting for sex, body mass index, waist circumference or cardiorespiratory fitness. PVS demonstrated strong agreement with Polar H10 in monitoring heart rate during HIIT in adolescents within a school setting. Therefore, it is valid to replace traditional inconvenient chest strap heart rate monitors with a practical and ergonomic armband PVS, which could largely enhance the feasibility of HIIT fidelity monitoring. FAU - Liu, Yong AU - Liu Y AD - Children's Health and Exercise Research Centre, Public Health and Sports Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK. FAU - Barker, Alan R AU - Barker AR AD - Children's Health and Exercise Research Centre, Public Health and Sports Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK. FAU - Li, Minghui AU - Li M AD - Faculty of Sports Science, Ningbo University, Ningbo, China. FAU - Gu, Yaodong AU - Gu Y AD - Faculty of Sports Science, Ningbo University, Ningbo, China. FAU - Williams, Craig A AU - Williams CA AUID- ORCID: 0000-0002-1740-6248 AD - Children's Health and Exercise Research Centre, Public Health and Sports Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK. LA - eng PT - Journal Article PT - Validation Study DEP - 20250414 PL - England TA - J Sports Sci JT - Journal of sports sciences JID - 8405364 SB - IM MH - Humans MH - *High-Intensity Interval Training MH - Male MH - Female MH - *Heart Rate/physiology MH - Adolescent MH - Child MH - Cardiorespiratory Fitness/physiology MH - Reproducibility of Results MH - Schools MH - Monitoring, Physiologic/instrumentation OTO - NOTNLM OT - Validation OT - adolescents OT - heart rate monitors OT - high-intensity interval training OT - school EDAT- 2025/04/14 12:25 MHDA- 2025/05/06 12:42 CRDT- 2025/04/14 10:03 PHST- 2025/05/06 12:42 [medline] PHST- 2025/04/14 12:25 [pubmed] PHST- 2025/04/14 10:03 [entrez] AID - 10.1080/02640414.2025.2491163 [doi] PST - ppublish SO - J Sports Sci. 2025 Jun;43(11):1076-1084. doi: 10.1080/02640414.2025.2491163. Epub 2025 Apr 14. PMID- 40226705 OWN - NLM STAT- MEDLINE DCOM- 20250414 LR - 20250430 IS - 1520-6394 (Electronic) IS - 1091-4269 (Print) IS - 1091-4269 (Linking) VI - 2024 DP - 2024 TI - Internal Consistency and Validity of a Short Spanish Version (10-Items) of the Center for Epidemiological Studies Depression Scale for Children and Adolescents (CES-DC). PG - 5409747 LID - 10.1155/2024/5409747 [doi] LID - 5409747 AB - Purpose: The 20-item Center for Epidemiological Studies Depression Scale for Children and Adolescents (CES-DC) is an instrument for screening of depression with good psychometric properties. This study aimed to examine the construct validity in terms of structural and convergent validity, the internal consistency, and the concurrent validity of a shorter 10-item version of this scale. Methods: This was a cross-sectional validation study including 671 schoolchildren aged 9-11, from Cuenca, Spain. Depression was assessed using the 20-item CES-DC scale. We selected the 10 items with the highest factorial loading for a shorter version. Sociodemographic, anthropometric, fitness, and quality of life variables were considered to analyse convergent and discriminant validity. Results: For the structural validity, confirmatory factor analyses revealed a three-factor latent structure for the 20-item CES-DC and a single factor in the 10-item version. Internal consistency measured by Cronbach's alpha and omega statistic were 0.85 for 20-item CES-DC and 0.84 for 10-item CES-DC. Intraclass correlation coefficient between the two scales was 0.94. Convergent validity was tested through the correlation coefficients and regression models between both either CES-DC versions with body mass index, waist circumference, fitness, and quality of life measures, which were similar. For the concurrent validity, concordance analysis and the ROC curve showed an equivalent cut-off point for the 10-item CES-DC. The 20-item CES-DC classified a total of 33.1% of the sample as at risk of depression, while the 10-item CES-DC classified 30.4%. Conclusion: This study indicates that both the 20-item and 10-item versions of the CES-DC have good internal consistency and structural validity in schoolchildren. Therefore, this short version can be used as a reliable and valid instrument for screening depression that is less time consuming and easy to use in clinical and scholarly contexts, potentially improving early detection and intervention for depression. Trial Registration: ClinicalTrials.gov identifier: NCT03236337. CI - Copyright (c) 2024 Maria Eugenia Visier-Alfonso et al. FAU - Visier-Alfonso, Maria Eugenia AU - Visier-Alfonso ME AUID- ORCID: 0000-0003-0364-8032 AD - Faculty of Nursing, Universidad de Castilla-La Mancha, Cuenca, Spain. AD - Health and Social Research Center, Universidad de Castilla-La Mancha, Cuenca, Spain. FAU - Jimenez-Lopez, Estela AU - Jimenez-Lopez E AUID- ORCID: 0000-0001-8553-7701 AD - Faculty of Nursing, Universidad de Castilla-La Mancha, Cuenca, Spain. AD - Health and Social Research Center, Universidad de Castilla-La Mancha, Cuenca, Spain. AD - Center for Biomedical Research Network in Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid 28029, Spain. FAU - Rodriguez-Gutierrez, Eva AU - Rodriguez-Gutierrez E AUID- ORCID: 0000-0001-6907-7872 AD - Health and Social Research Center, Universidad de Castilla-La Mancha, Cuenca, Spain. AD - Research Network on Chronicity, Primary Care and Health Promotion (RICAPPS), Cuenca, Spain. FAU - Mesas, Arthur Eumann AU - Mesas AE AUID- ORCID: 0000-0002-0088-8607 AD - Faculty of Nursing, Universidad de Castilla-La Mancha, Cuenca, Spain. AD - Health and Social Research Center, Universidad de Castilla-La Mancha, Cuenca, Spain. FAU - Nunez de Arenas-Arroyo, Sergio AU - Nunez de Arenas-Arroyo S AUID- ORCID: 0000-0001-7774-8437 AD - Health and Social Research Center, Universidad de Castilla-La Mancha, Cuenca, Spain. AD - Research Network on Chronicity, Primary Care and Health Promotion (RICAPPS), Cuenca, Spain. FAU - Diaz-Goni, Valentina AU - Diaz-Goni V AUID- ORCID: 0000-0002-1724-1893 AD - Health and Social Research Center, Universidad de Castilla-La Mancha, Cuenca, Spain. FAU - Alvarez-Bueno, Celia AU - Alvarez-Bueno C AUID- ORCID: 0000-0002-6176-1618 AD - Faculty of Nursing, Universidad de Castilla-La Mancha, Cuenca, Spain. AD - Health and Social Research Center, Universidad de Castilla-La Mancha, Cuenca, Spain. FAU - Martinez-Vizcaino, Vicente AU - Martinez-Vizcaino V AUID- ORCID: 0000-0001-6121-7893 AD - Health and Social Research Center, Universidad de Castilla-La Mancha, Cuenca, Spain. AD - Research Network on Chronicity, Primary Care and Health Promotion (RICAPPS), Cuenca, Spain. AD - Faculty of Medicine, Universidad Autonoma de Chile, Talca, Chile. LA - eng SI - ClinicalTrials.gov/NCT03236337 PT - Clinical Trial PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20240925 PL - United States TA - Depress Anxiety JT - Depression and anxiety JID - 9708816 SB - IM MH - Child MH - Female MH - Humans MH - Male MH - Cross-Sectional Studies MH - *Depression/diagnosis MH - Factor Analysis, Statistical MH - *Psychiatric Status Rating Scales/standards MH - Psychometrics/instrumentation MH - Quality of Life MH - Reproducibility of Results MH - Spain PMC - PMC11918615 OTO - NOTNLM OT - CES-DdC OT - children OT - depression OT - factor structure OT - psychometric properties OT - validation COIS- The author declares no conflicts of interest. EDAT- 2025/04/14 17:28 MHDA- 2025/04/14 17:29 PMCR- 2024/09/25 CRDT- 2025/04/14 07:24 PHST- 2024/03/27 00:00 [received] PHST- 2024/07/26 00:00 [revised] PHST- 2024/08/11 00:00 [accepted] PHST- 2025/04/14 17:29 [medline] PHST- 2025/04/14 17:28 [pubmed] PHST- 2025/04/14 07:24 [entrez] PHST- 2024/09/25 00:00 [pmc-release] AID - 10.1155/2024/5409747 [doi] PST - epublish SO - Depress Anxiety. 2024 Sep 25;2024:5409747. doi: 10.1155/2024/5409747. eCollection 2024. PMID- 40226541 OWN - NLM STAT- MEDLINE DCOM- 20250414 LR - 20250415 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 13 DP - 2025 TI - Psychometric properties of the Chinese version physical literacy assessment questionnaire among high school students in Gansu, China. PG - e19093 LID - 10.7717/peerj.19093 [doi] LID - e19093 AB - INTRODUCTION: The concept of physical literacy (PL) originated from the philosophy of lifelong sports, and its development is crucial for achieving lifelong sports goals. The Portuguese Physical Literacy Assessment Questionnaire (PPLA-Q) is a tool designed to assess the physical literacy of high school students, demonstrating good reliability and validity. The aim of this study is to translate and adapt the PPLA-Q into Chinese (PPLA-Q-C) and validate its applicability among adolescents in Gansu, China through confirmatory factor analysis (CFA). METHODS: A total of 780 middle school students from Gansu Province, China, aged 15-18, participated. After screening, the final sample size was 729. The English PPLA-Q was translated into Chinese and validated through expert review and pre-testing. Data were collected in September 2022 via a self-reported survey, with an effective response rate of 93.5%. Data analysis was conducted using Mplus 8.3 with the robust maximum likelihood (MLR) estimator. Confirmatory factor analysis (CFA) assessed model fit using standardized root mean square residual (SRMR), root mean square error of approximation (RMSEA), Tucker-Lewis index (TLI), and comparative fit index (CFI) indices. Construct validity was evaluated through composite reliability (CR), average variance extracted (AVE), and factor correlations. The study followed ethical guidelines and received approval from Universiti Sains Malaysia's ethics committee. RESULTS: All observed items exhibited high factor loadings, confirming that the assumed model, consisting of 40 items grouped into four latent variables, was consistent with the original model. The CFA model demonstrated a good fit with the data, as indicated by fit indices: RMSEA = .024 (90% CI [.020-.027]), CFI = .978, TLI = .977, SRMR = .032. CONCLUSION: The final measurement model comprised 40 items, all retained and considered acceptable for the sample. The study results suggest that the Chinese version of PPLA-Q (PPLA-Q-C) is effective and reliable for assessing the PL of high school students in Gansu Province, China. Education practitioners and policymakers can utilize the PPLA-Q-C framework in their future work to assess the PL of Chinese-speaking students. CI - (c)2025 Qu et al. FAU - Qu, Zilu AU - Qu Z AD - School of Physical Education, Guangzhou University, Guangzhou, Guangdong, China. FAU - Wu, Jiarun AU - Wu J AD - School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. FAU - Kueh, Yee Cheng AU - Kueh YC AD - School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. FAU - Ye, Dongqing AU - Ye D AD - School of Physical Education, Guangzhou University, Guangzhou, Guangdong, China. FAU - Kuan, Garry AU - Kuan G AD - School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. LA - eng PT - Journal Article PT - Validation Study DEP - 20250409 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - Adolescent MH - China MH - *Psychometrics MH - Male MH - Female MH - Reproducibility of Results MH - *Students/statistics & numerical data/psychology MH - Surveys and Questionnaires/standards MH - Factor Analysis, Statistical MH - *Health Literacy MH - Translations MH - Schools PMC - PMC11992972 OTO - NOTNLM OT - CFA OT - PPLA-Q OT - Physical activity OT - Sample size COIS- ZQ, JW, GK, DY and KYC declared no conflict of interest. EDAT- 2025/04/14 17:28 MHDA- 2025/04/14 17:29 PMCR- 2025/04/09 CRDT- 2025/04/14 07:22 PHST- 2024/09/04 00:00 [received] PHST- 2025/02/11 00:00 [accepted] PHST- 2025/04/14 17:29 [medline] PHST- 2025/04/14 17:28 [pubmed] PHST- 2025/04/14 07:22 [entrez] PHST- 2025/04/09 00:00 [pmc-release] AID - 19093 [pii] AID - 10.7717/peerj.19093 [doi] PST - epublish SO - PeerJ. 2025 Apr 9;13:e19093. doi: 10.7717/peerj.19093. eCollection 2025. PMID- 40225328 OWN - NLM STAT- MEDLINE DCOM- 20250414 LR - 20250415 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 16 DP - 2025 TI - Association between gestational weight gain and perinatal outcomes among women with gestational diabetes mellitus. PG - 1531814 LID - 10.3389/fendo.2025.1531814 [doi] LID - 1531814 AB - OBJECTIVE: This study identifies the optimal gestational weight gain (GWG) range for women with gestational diabetes mellitus (GDM) in singleton pregnancies and examines the relationship between GWG patterns and perinatal outcomes. METHODS: We included 18,548 pregnant women diagnosed with GDM via a 75g glucose tolerance test at Fujian Maternal and Child Health Hospital from 2011 to 2022. Data on demographics, GWG, delivery details, and maternal and infant outcomes were collected. Subjects were divided into training and validation sets (7:3 ratio) and classified by pre-pregnancy BMI: underweight, normal weight, overweight, and obese. Logistic regression in the training set was conducted to determine optimal GWG for each group, and examined the relationship between adverse outcomes and the Institute of Medicine(IOM), Chinese nutrition society(CNS), and study-derived (AOR) standards in the validation set. RESULTS: Among participants, 17.0% pregnant women gained insufficient GWG, 49.2% gained appropriate GWG, and 33.9% with excessive GWG. The optimal GWG for underweight, normal weight, overweight, and women with obesity were 12-14 kg, 8-14 kg, 6-10 kg, and 2-4 kg, respectively. Insufficient GWG in IOM and AOR standard increased composite adverse outcomes among underweight women. Normal weight: Insufficient GWG per CNS and AOR increased composite adverse outcomes; excessive GWG per all standards increased adverse outcomes. Insufficient GWG per all standards reduced the risk of small-for-gestational-age (SGA) infants, while excessive GWG increased the risk of large-for-gestational-age (LGA) infants, gestational hypertension, and cesarean section. Overweight: Excessive GWG per CNS and AOR increased composite adverse outcomes; excessive GWG per all standards increased the risk of cesarean delivery. Obese: Insufficient GWG per IOM and CNS increased composite adverse outcomes. CONCLUSION: GWG significantly influences adverse pregnancy outcomes. Compared to IOM guidelines, CNS recommendations and study-derived GWG ranges are more suitable for Chinese women with GDM in singleton pregnancies. CI - Copyright (c) 2025 Guo, Lin, Dong and Lin. FAU - Guo, Zize AU - Guo Z AD - Department of Women's Health Care, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China. FAU - Lin, Lihua AU - Lin L AD - Department of Healthcare, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian, China. FAU - Dong, Jiayi AU - Dong J AD - Department of Women's Health Care, Fujian Obstetrics and Gynecology Hospital, Fuzhou, Fujian, China. FAU - Lin, Juan AU - Lin J AD - Department of Obstetrics, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian, China. LA - eng PT - Journal Article DEP - 20250328 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Diabetes, Gestational/epidemiology/physiopathology MH - *Gestational Weight Gain/physiology MH - Adult MH - *Pregnancy Outcome/epidemiology MH - Infant, Newborn MH - Body Mass Index MH - Overweight MH - China/epidemiology MH - Thinness MH - Birth Weight MH - Retrospective Studies PMC - PMC11985421 OTO - NOTNLM OT - adverse outcomes OT - body mass index OT - gestational diabetes mellitus OT - gestational weight gain OT - singleton pregnancy COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/04/14 17:28 MHDA- 2025/04/14 17:29 PMCR- 2025/01/01 CRDT- 2025/04/14 07:09 PHST- 2024/11/21 00:00 [received] PHST- 2025/03/10 00:00 [accepted] PHST- 2025/04/14 17:29 [medline] PHST- 2025/04/14 17:28 [pubmed] PHST- 2025/04/14 07:09 [entrez] PHST- 2025/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2025.1531814 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2025 Mar 28;16:1531814. doi: 10.3389/fendo.2025.1531814. eCollection 2025. PMID- 40223576 OWN - NLM STAT- MEDLINE DCOM- 20250414 LR - 20250416 IS - 1468-3148 (Electronic) IS - 1360-2322 (Print) IS - 1360-2322 (Linking) VI - 38 IP - 2 DP - 2025 Mar TI - Life Satisfaction, Global Health and Mood in Prader-Willi Syndrome: Use of PROMIS and Glasgow Depression Scales. PG - e70053 LID - 10.1111/jar.70053 [doi] LID - e70053 AB - BACKGROUND: Prader-Willi syndrome (PWS) is a rare neurodevelopmental disorder with symptoms that impact health and quality of life (QOL). There is limited data on global health, QOL and the relationship with mood in individuals with PWS. METHODS: Parents completed three validated assessments, the Glasgow Depression Scale-Carer Supplement (GDS-CS), PROMIS Parent-Proxy Global Health 7 and PROMIS Parent-Proxy Life Satisfaction 8b, for 527 individuals with PWS. RESULTS: Mean GDS-CS score was 8.29 (SD 4.55), and 18% had a score of 13+, reflective of possible depression. Mean PROMIS Global Health and Life Satisfaction scores were 41.46 (SD 8.48) and 43.39 (SD 8.48), respectively, and are lower compared to the general population. Both PROMIS scales worsened with age, and scores on the PROMIS and GDS-CS were associated with parent reports of depression for the person with PWS. CONCLUSIONS: These validated instruments may be useful for assessing mood and QOL in PWS. CI - (c) 2025 The Author(s). Journal of Applied Research in Intellectual Disabilities published by John Wiley & Sons Ltd. FAU - Schwartz, Lauren AU - Schwartz L AUID- ORCID: 0000-0002-4022-1196 AD - Foundation for Prader-Willi Research, Covina, California, USA. FAU - Vrana-Diaz, Caroline J AU - Vrana-Diaz CJ AUID- ORCID: 0000-0001-9037-2761 AD - Foundation for Prader-Willi Research, Covina, California, USA. FAU - Bohonowych, Jessica E AU - Bohonowych JE AUID- ORCID: 0009-0006-1021-9956 AD - Foundation for Prader-Willi Research, Covina, California, USA. FAU - Matesevac, Lisa AU - Matesevac L AUID- ORCID: 0000-0002-7756-1901 AD - Foundation for Prader-Willi Research, Covina, California, USA. FAU - Strong, Theresa V AU - Strong TV AUID- ORCID: 0000-0001-6783-8703 AD - Foundation for Prader-Willi Research, Covina, California, USA. LA - eng GR - Foundation for Prader-Willi Research/ PT - Journal Article PL - England TA - J Appl Res Intellect Disabil JT - Journal of applied research in intellectual disabilities : JARID JID - 9613616 SB - IM MH - Humans MH - *Prader-Willi Syndrome/psychology MH - Male MH - Female MH - *Quality of Life/psychology MH - Adult MH - Adolescent MH - *Personal Satisfaction MH - Child MH - Young Adult MH - *Depression/diagnosis/psychology/etiology MH - *Affect/physiology MH - *Psychiatric Status Rating Scales/standards MH - *Global Health MH - Child, Preschool MH - Middle Aged PMC - PMC11995245 OTO - NOTNLM OT - Prader-Willi syndrome OT - depression OT - developmental disability OT - global health OT - intellectual disability OT - quality of life COIS- The authors declare no conflicts of interest. EDAT- 2025/04/14 06:23 MHDA- 2025/04/14 06:24 PMCR- 2025/04/14 CRDT- 2025/04/14 04:43 PHST- 2025/03/25 00:00 [revised] PHST- 2024/11/14 00:00 [received] PHST- 2025/04/02 00:00 [accepted] PHST- 2025/04/14 06:24 [medline] PHST- 2025/04/14 06:23 [pubmed] PHST- 2025/04/14 04:43 [entrez] PHST- 2025/04/14 00:00 [pmc-release] AID - JAR70053 [pii] AID - 10.1111/jar.70053 [doi] PST - ppublish SO - J Appl Res Intellect Disabil. 2025 Mar;38(2):e70053. doi: 10.1111/jar.70053. PMID- 40223297 OWN - NLM STAT- MEDLINE DCOM- 20260413 LR - 20260413 IS - 1545-1569 (Electronic) IS - 1055-6656 (Linking) VI - 63 IP - 5 DP - 2026 May TI - Food Texture Preference and Oral Clefts: A New Perspective from a Case-Control Study. PG - 1297-1307 LID - 10.1177/10556656251332119 [doi] AB - ObjectiveAccording to food texture preference (FTP), children can be categorized as soft likers (SL) or hard likers. This study explored the relationship between FTP and having an oral cleft in children of the mixed dentition stage. The hypothesis stated that having an oral cleft phenotype would shift a child's FTP toward soft-food textures.DesignA case-control study that employed a validated child food texture preference questionnaire (CFTPQ) to assess FTP. Children's general demographics, food neophobia, and food intake data were collected using validated questionnaires. A pediatric dentist evaluated the children's dental status.SettingData was collected in a dental teaching center and 5 public schools for cases and controls, respectively.ParticipantsThis study included 6- to 13-year-old children with treated oral clefts (n = 87) and their non-cleft peers (n = 413).Main outcome measureCFTPQ index.ResultsCases demonstrated a significantly lower mean CFTPQ index (31.97 +/- 16.20) compared to controls (42.07 +/- 16.42, P < .001). A total of 45 cases (51%) and 94 (23%) controls were identified as SL (P < .001). Cases were more food neophobic (42.67 +/- 9.03) compared to controls (39.03 +/- 11.62, P = .002). The final linear regression model identified age and oral cleft phenotype as variables of significant impact on FTP. Moreover, the cleft type, the type, and the number of surgical interventions received did not significantly influence their FTP.ConclusionsThis study offers new insight into a potential relationship between FTP and oral clefts in 6- to 13-year-old children. Children with cleft lip and/or palate demonstrate a preference for soft food textures and are more food-neophobic compared to their non-cleft counterparts. FAU - Alazzam, Melanie F AU - Alazzam MF AUID- ORCID: 0000-0002-9295-6645 AD - Department of Oral Medicine and Oral Surgery, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan. RINGGOLD: 108607 FAU - Daoud, Soaad AU - Daoud S AUID- ORCID: 0009-0002-5712-7355 AD - Graduate Pediatric Dentistry Program, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan. RINGGOLD: 108607 FAU - Aljundi, Suhad AU - Aljundi S AUID- ORCID: 0000-0002-8949-8604 AD - Department of Preventive Dentistry, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan. RINGGOLD: 108607 FAU - Hammouri, Hanan AU - Hammouri H AUID- ORCID: 0000-0001-7009-1022 AD - Department of Mathematics and Statistics, Faculty of Science and Arts, Jordan University of Science and Technology, Irbid, Jordan. RINGGOLD: 108611 FAU - Al-Halholi, Abdullah AU - Al-Halholi A AUID- ORCID: 0009-0000-9467-330X AD - Department of Orthodontics, Royal Medical Services, Amman, Jordan. RINGGOLD: 155132 FAU - Alhashlamon, Karina AU - Alhashlamon K AUID- ORCID: 0009-0000-5406-6871 AD - Internship Program, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan. RINGGOLD: 108607 FAU - Rawashdeh, Ma'amon AU - Rawashdeh M AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ibn Sina University for Medical Sciences, Amman, Jordan. RINGGOLD: 643874 FAU - Van Aalst, John AU - Van Aalst J AD - Private Practice, Walton, KY, USA. LA - eng PT - Journal Article DEP - 20250413 PL - United States TA - Cleft Palate Craniofac J JT - The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association JID - 9102566 SB - IM MH - Humans MH - Case-Control Studies MH - Child MH - Male MH - Female MH - Adolescent MH - *Cleft Lip/psychology/physiopathology MH - *Cleft Palate/psychology/physiopathology MH - *Food Preferences MH - Surveys and Questionnaires OTO - NOTNLM OT - cleft lip OT - cleft palate OT - food preference OT - mixed dentition OT - neophobia OT - texture COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/04/14 06:23 MHDA- 2026/04/13 12:38 CRDT- 2025/04/14 01:53 PHST- 2026/04/13 12:38 [medline] PHST- 2025/04/14 06:23 [pubmed] PHST- 2025/04/14 01:53 [entrez] AID - 10.1177/10556656251332119 [doi] PST - ppublish SO - Cleft Palate Craniofac J. 2026 May;63(5):1297-1307. doi: 10.1177/10556656251332119. Epub 2025 Apr 13. PMID- 40222430 OWN - NLM STAT- MEDLINE DCOM- 20250821 LR - 20260907 IS - 1532-8406 (Electronic) IS - 0883-5403 (Linking) VI - 40 IP - 9 Suppl 1 DP - 2025 Sep TI - Preoperative Expectations and Functional Scores for Primary Total Knee Arthroplasty Vary Based on Health Literacy. PG - S171-S177 LID - S0883-5403(25)00365-1 [pii] LID - 10.1016/j.arth.2025.04.027 [doi] AB - BACKGROUND: Health literacy (HL) is essential for managing medical conditions, including primary total knee arthroplasty (TKA). We evaluated whether HL was related to patient-reported preoperative expectations for improvement and baseline patient-reported functional scores. METHODS: Elective primary TKAs (n = 345) performed at an academic hip and knee center were prospectively enrolled in a study evaluating mediators of patient-reported outcomes. The sample consisted of 68% women, with an average age and body mass index of 67 years (range, 42 to 90) and 36 (range, 18 to 70). Validated preoperative measures included a single-item assessment of HL, Knee Society expectations for pain and functional improvement, Knee Injury and Osteoarthritis (KOOS JR) joint health, and Patient-Reported Outcomes Measurement Information System (PROMIS) global mental and physical health. Multivariable analyses controlling for covariates were conducted. RESULTS: Higher HL was reported by 77% of patients, with 23% reporting lower HL. Higher HL was associated with higher mean expectation scores for pain relief (P = 0.014) and improvement in activities of daily living (P = 0.009) and recreational, sports, and leisure activities (P < 0.001). These differences were reflected in a higher mean total expectations score (P = 0.001). The mean PROMIS global mental (P < 0.001) and physical (P = 0.010) health were significantly higher in patients who have higher HL. The mean KOOS JR scores did not differ based on higher versus lower HL (P = 0.57). HL remained a significant mediator of preoperative functional scores in multivariable analyses. CONCLUSIONS: Study findings suggest that lower HL correlated with lower preoperative expectations and PROMIS baseline scores, despite equally poor KOOS JR scores, indicating equal knee dysfunction between groups. These differences may influence patient-reported postoperative outcomes, which will soon be tied to reimbursement. Preoperative patient education may benefit from a better understanding of individual differences in HL. CI - Copyright (c) 2025 Elsevier Inc. All rights reserved. FAU - Ziemba-Davis, Mary AU - Ziemba-Davis M AD - Indiana University Health Multispecialty Musculoskeletal Center, Carmel, Indiana. FAU - Zanolla, Jared A AU - Zanolla JA AD - Indiana University School of Medicine, Department of Graduate Medical Education, Indianapolis, Indiana. FAU - Sonn, Kevin A AU - Sonn KA AD - Indiana University School of Medicine, Department of Orthopaedic Surgery, Indianapolis, Indiana. FAU - Buller, Leonard T AU - Buller LT AD - Indiana University School of Medicine, Department of Orthopaedic Surgery, Indianapolis, Indiana. LA - eng PT - Journal Article DEP - 20250411 PL - United States TA - J Arthroplasty JT - The Journal of arthroplasty JID - 8703515 SB - IM MH - Humans MH - *Arthroplasty, Replacement, Knee/psychology MH - Female MH - Male MH - Middle Aged MH - Aged MH - *Health Literacy MH - Patient Reported Outcome Measures MH - Adult MH - Aged, 80 and over MH - Prospective Studies MH - Osteoarthritis, Knee/surgery MH - Activities of Daily Living MH - Preoperative Period MH - Young Adult MH - Adolescent OTO - NOTNLM OT - expectations for total knee arthroplasty surgery OT - health literacy OT - mediators of patient-reported outcomes OT - patient-reported outcomes OT - total knee arthroplasty EDAT- 2025/04/14 00:25 MHDA- 2025/09/08 07:55 CRDT- 2025/04/13 19:35 PHST- 2024/12/13 00:00 [received] PHST- 2025/04/04 00:00 [revised] PHST- 2025/04/07 00:00 [accepted] PHST- 2025/09/08 07:55 [medline] PHST- 2025/04/14 00:25 [pubmed] PHST- 2025/04/13 19:35 [entrez] AID - S0883-5403(25)00365-1 [pii] AID - 10.1016/j.arth.2025.04.027 [doi] PST - ppublish SO - J Arthroplasty. 2025 Sep;40(9 Suppl 1):S171-S177. doi: 10.1016/j.arth.2025.04.027. Epub 2025 Apr 11. PMID- 40219024 OWN - NLM STAT- MEDLINE DCOM- 20250412 LR - 20250723 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 7 DP - 2025 Apr 4 TI - Eating in the Absence of Hunger in Hispanic Preschoolers: Relationships with Child Sex, Food Preference, and Weight Status. LID - 10.3390/nu17071266 [doi] LID - 1266 AB - Background/Objectives: This study examines the relationship of eating in the absence of hunger (EAH) with child sex, food preference, and body mass index (BMI) percentiles in primarily Hispanic preschoolers, an understudied population. Methods: This was a secondary analysis of data from 211 children (79% Hispanic) aged 3 to 5 years from low-income families who completed a cluster randomized controlled trial from September 2017 to June 2020. Weight and height were used to calculate BMI percentiles. Sweet (animal crackers) and salty (pretzels) snacks were used to conduct a validated classroom-based EAH assessment. A generalized estimating equation (GEE) approach investigated associations between the grams of snacks consumed and BMI percentiles. A set of nested multivariable GEEs were estimated, while adjusting for potentially important covariates. Results: Boys significantly consumed more snacks than girls (13.34 +/- 9.71 g vs. 8.13 +/- 7.36 g; p < 0.001). Children who indicated greater preference for sweet snacks consumed more sweet snacks (r = 0.19; b = 2.05, p < 0.001) and total grams of total snacks (r = 0.18; b = 2.42, p = 0.004) but not salty snacks (pretzels). Consuming more sweet snacks was significantly associated with higher BMI percentiles (b = 0.55; p = 0.024). Conclusions: The findings suggest that a preference for sweet snacks is associated with EAH, and eating sweet snacks in the absence of hunger is related to higher BMI percentiles. Obesity prevention programs may focus on addressing eating sweet snacks in the absence of hunger starting in early childhood. FAU - Verdezoto Alvarado, Adriana AU - Verdezoto Alvarado A AUID- ORCID: 0000-0001-8338-4692 AD - Department of Behavioral Health and Nutrition, College of Health Sciences, University of Delaware, 100 Discovery Blvd., Newark, DE 19713, USA. FAU - Suh, Bin C AU - Suh BC AUID- ORCID: 0000-0001-8853-4709 AD - Bureau of Assessment and Evaluation, Arizona Department of Health Services, 150 N 18th Ave, Phoenix, AZ 85007, USA. FAU - Todd, Michael AU - Todd M AUID- ORCID: 0000-0002-1981-4245 AD - Edson College of Nursing and Health Innovation, Arizona State University, 550 N 3rd Street, Phoenix, AZ 85004, USA. FAU - Szeszulski, Jacob AU - Szeszulski J AD - Institute for Advancing Health Through Agriculture (IHA) at Texas A&M AgriLife Research, 17360 Coit Rd, Dallas, TX 75252, USA. FAU - Lorenzo, Elizabeth AU - Lorenzo E AUID- ORCID: 0000-0002-2336-2114 AD - School of Nursing, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555, USA. FAU - Bruening, Meg AU - Bruening M AUID- ORCID: 0000-0002-8301-8040 AD - Department of Nutritional Sciences, College of Health and Human Development, Pennsylvania State University, 110 Chandlee Lab, University Park, PA 16802, USA. FAU - Schuchardt, Clare AU - Schuchardt C AD - Center for Health Promotion and Disease Prevention, Edson College of Nursing and Health Innovation, Arizona State University, 550 N 3rd Street, Phoenix, AZ 85004, USA. FAU - Lee, Rebecca E AU - Lee RE AUID- ORCID: 0000-0002-9011-0689 AD - Center for Health Promotion and Disease Prevention, Edson College of Nursing and Health Innovation, Arizona State University, 550 N 3rd Street, Phoenix, AZ 85004, USA. LA - eng GR - 1F31NR017560-01/NR/NINR NIH HHS/United States GR - N/A/Institute for Advancing Health Through Agriculture (IHA) at Texas A&M University/ GR - K23 AG083231/AG/NIA NIH HHS/United States GR - F31 NR017560/NR/NINR NIH HHS/United States GR - U01 MD010667/MD/NIMHD NIH HHS/United States GR - N/A/Jonas Scholar Nurse Leader Cohort 2016-2018 award/ GR - U01 MD010667-01/National Institute of Minority Health and Health Disparities/ PT - Journal Article DEP - 20250404 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Child, Preschool MH - Female MH - Humans MH - Male MH - Body Mass Index MH - *Body Weight MH - *Feeding Behavior MH - *Food Preferences MH - *Hispanic or Latino/psychology/statistics & numerical data MH - *Hunger MH - Sex Factors MH - Snacks MH - Randomized Controlled Trials as Topic MH - Cluster Analysis MH - Secondary Data Analysis PMC - PMC11990248 OTO - NOTNLM OT - Hispanic children OT - eating in the absence of hunger OT - preschool children OT - weight status COIS- Szeszulski was partly supported by the Institute for Advancing Health Through Agriculture (IHA) at Texas A&M University. Lorenzo reports grants from National Institutes of Health during the conduct of the study and another from Jonas Philanthropies, outside the submitted work. Todd reports grants from the National Institutes of Health and the Oncology Nursing Society Foundation during the conduct of the study. Lee reports grants from National Institutes of Health during the conduct of the study. All other authors have indicated that they have no potential conflicts of interest to disclose. EDAT- 2025/04/12 21:54 MHDA- 2025/04/12 21:55 PMCR- 2025/04/04 CRDT- 2025/04/12 01:08 PHST- 2025/03/14 00:00 [received] PHST- 2025/04/02 00:00 [revised] PHST- 2025/04/02 00:00 [accepted] PHST- 2025/04/12 21:55 [medline] PHST- 2025/04/12 21:54 [pubmed] PHST- 2025/04/12 01:08 [entrez] PHST- 2025/04/04 00:00 [pmc-release] AID - nu17071266 [pii] AID - nutrients-17-01266 [pii] AID - 10.3390/nu17071266 [doi] PST - epublish SO - Nutrients. 2025 Apr 4;17(7):1266. doi: 10.3390/nu17071266. PMID- 40219019 OWN - NLM STAT- MEDLINE DCOM- 20250412 LR - 20250414 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 7 DP - 2025 Apr 3 TI - Barriers and Enablers of Healthy Eating Among University Students in Oaxaca de Juarez: A Mixed-Methods Study. LID - 10.3390/nu17071263 [doi] LID - 1263 AB - Background/Objectives: The transition to university life brings significant social, psychological, and environmental changes, making it a critical period for establishing long-term dietary habits. However, many Mexican university students fail to meet national dietary guidelines, increasing their risk of non-communicable diseases. This study examines the determinants of healthy eating among university students in Oaxaca using a holistic, multi-level approach grounded in the Social Ecological Model (SEM) and Social Cognitive Theory (SCT). Methods: A mixed-methods approach was employed, integrating ethnography with a validated self-report questionnaire completed by 411 students at the Universidad Autonoma Benito Juarez de Oaxaca (UABJO). The ethnographic data included observations, field notes, photographs, informal conversations, and 13 semi-structured interviews. Data triangulation provided a comprehensive understanding of dietary behaviors by capturing both self-reported patterns and real-world eating practices and the food environment, as captured through ethnographic methods. The analysis included descriptive statistics, normality tests, and parametric tests to assess significant differences. Results: The findings revealed a decline in diet quality, characterized by low fruit and vegetable intake, high snack consumption, and irregular meal patterns, particularly among students living independently. Key barriers included academic stress, time constraints, low cooking self-efficacy, limited nutritional knowledge, peer pressure, and negative social norms, which contributed to reliance on convenient, processed foods. The lack of healthy food options on campus and the high perceived cost of nutritious food further led students to prioritize cheap, calorie-dense foods over healthier choices. Conversely, enablers included structured university schedules; peer support; hands-on culinary interventions; and improved access to affordable, healthy food. Conclusions: Addressing these barriers requires multi-level interventions that enhance nutrition literacy, cooking self-efficacy, and peer-led strategies while improving the campus food environment. Future research should explore SCT-based initiatives leveraging social networks and culinary education to foster sustainable dietary behavior change in university settings and assess how these findings can be applied in other socioeconomic and cultural contexts. FAU - Jurado-Gonzalez, Patricia AU - Jurado-Gonzalez P AUID- ORCID: 0000-0003-0632-0390 AD - NUTRALiSS, Faculty of Health Sciences, Open University of Catalonia (UOC), 08018 Barcelona, Spain. FAU - Lopez-Toledo, Sabina AU - Lopez-Toledo S AUID- ORCID: 0000-0002-1369-0261 AD - Health Sciences and Disease Study Center, Faculty of Dentistry, Benito Juarez Autonomous University of Oaxaca (UABJO), Oaxaca de Juarez 68120, Oaxaca, Mexico. FAU - Bach-Faig, Anna AU - Bach-Faig A AUID- ORCID: 0000-0001-8861-8013 AD - NUTRALiSS, Faculty of Health Sciences, Open University of Catalonia (UOC), 08018 Barcelona, Spain. FAU - Medina, Francesc-Xavier AU - Medina FX AUID- ORCID: 0000-0002-8067-355X AD - UNESCO Chair on Food, Culture and Development, Open University of Catalonia (UOC), 08018 Barcelona, Spain. AD - Epi4Health Research Group, Faculty of Health Sciences, Open University of Catalonia (UOC), 08018 Barcelona, Spain. LA - eng GR - 2024 FI-1 00212/AGAUR-FI predoctoral program, Joan Oro grants and the European Social Fund Plus/ PT - Journal Article DEP - 20250403 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Diet, Healthy/psychology MH - *Students/psychology MH - Universities MH - Female MH - Male MH - Young Adult MH - *Feeding Behavior/psychology MH - Adult MH - Mexico MH - Health Knowledge, Attitudes, Practice MH - Adolescent MH - Surveys and Questionnaires PMC - PMC11990523 OTO - NOTNLM OT - dietary patterns OT - ethnography OT - social cognitive theory OT - social ecological model OT - young adults COIS- The authors declare no conflicts of interest. EDAT- 2025/04/12 21:51 MHDA- 2025/04/12 21:52 PMCR- 2025/04/03 CRDT- 2025/04/12 01:08 PHST- 2025/02/28 00:00 [received] PHST- 2025/03/27 00:00 [revised] PHST- 2025/04/01 00:00 [accepted] PHST- 2025/04/12 21:52 [medline] PHST- 2025/04/12 21:51 [pubmed] PHST- 2025/04/12 01:08 [entrez] PHST- 2025/04/03 00:00 [pmc-release] AID - nu17071263 [pii] AID - nutrients-17-01263 [pii] AID - 10.3390/nu17071263 [doi] PST - epublish SO - Nutrients. 2025 Apr 3;17(7):1263. doi: 10.3390/nu17071263. PMID- 40218977 OWN - NLM STAT- MEDLINE DCOM- 20250412 LR - 20250416 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 7 DP - 2025 Mar 30 TI - Promoting Learning About Nutrition and Healthy Eating Behaviors in Chinese Children Through an Alternate Reality Game: A Pilot Study. LID - 10.3390/nu17071219 [doi] LID - 1219 AB - Background: Childhood obesity is a growing public-health concern in China and globally, a trend influenced by multiple factors, including poor eating behaviors and insufficient physical activity. While interactive health games have shown promise in improving children's nutrition education and healthy eating behaviors, few have been tailored for the Chinese context. This study aimed to develop and evaluate Happy Farm, Happy Meal (HFHM), an alternate reality game (ARG) integrated into Chinese elementary students' daily routines to enhance their nutrition knowledge and improve their eating behaviors. Methods: This pilot study employed a quasi-experimental design with two third-grade classes, which were randomly assigned to the HFHM intervention group (n = 40) or a no-game control group (n = 39). The game design was informed by a pre-intervention survey and interviews with caregivers and teachers, which identified key dietary challenges such as picky eating, slow eating, and food waste. Over a two-week period, the HFHM group engaged in food- and nutrition-focused tasks that were incorporated into their lunchtime routines. Pre- and post-intervention data were collected on nutrition knowledge, food waste, picky eating, and meal duration, with daily progress tracking in the HFHM group. Results: Compared to the control group, the HFHM group showed a significant increase in nutrition knowledge (p < 0.05), reduced food waste (p < 0.01), decreased picky eating (p < 0.01), and improved meal duration (p < 0.05). However, the small sample size and short intervention period limit generalizability. Conclusions: These findings suggest HFHM is a promising tool for improving nutrition education and dietary behaviors in Chinese children. Future research should validate these findings in a larger sample and assess long-term impacts. FAU - Wang, Ruobing AU - Wang R AUID- ORCID: 0009-0009-2075-0320 AD - School of Product Design, University of Canterbury, 20 Kirkwood Ave., Upper Riccarton, Christchurch 8041, New Zealand. FAU - Yao, Jie AU - Yao J AUID- ORCID: 0000-0002-5740-4773 AD - School of Economics and Management, Harbin Institute of Technology Shenzhen, Pingshan First Road, Shenzhen 518067, China. FAU - Leong, Claudia AU - Leong C AUID- ORCID: 0000-0002-6388-4646 AD - Department of Applied Science and Social Practice, Ara Institute of Canterbury, Madras Street, Christchurch Central City, Christchurch 8041, New Zealand. FAU - Moltchanova, Elena AU - Moltchanova E AUID- ORCID: 0000-0002-5788-4658 AD - School of Mathematics and Statistics, University of Canterbury, Private Bag 4800, Christchurch 8140, New Zealand. FAU - Hoermann, Simon AU - Hoermann S AD - School of Product Design, University of Canterbury, 20 Kirkwood Ave., Upper Riccarton, Christchurch 8041, New Zealand. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20250330 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Pilot Projects MH - Male MH - Female MH - Child MH - *Diet, Healthy MH - China MH - *Feeding Behavior MH - Health Knowledge, Attitudes, Practice MH - *Health Promotion/methods MH - Pediatric Obesity/prevention & control MH - *Health Education/methods PMC - PMC11990427 OTO - NOTNLM OT - Chinese children OT - alternate reality game OT - dietary behavior change OT - gamified learning OT - nutrition education OT - school-based nutrition intervention COIS- The authors declare no conflicts of interest. EDAT- 2025/04/12 21:54 MHDA- 2025/04/12 21:55 PMCR- 2025/03/30 CRDT- 2025/04/12 01:08 PHST- 2025/02/25 00:00 [received] PHST- 2025/03/24 00:00 [revised] PHST- 2025/03/26 00:00 [accepted] PHST- 2025/04/12 21:55 [medline] PHST- 2025/04/12 21:54 [pubmed] PHST- 2025/04/12 01:08 [entrez] PHST- 2025/03/30 00:00 [pmc-release] AID - nu17071219 [pii] AID - nutrients-17-01219 [pii] AID - 10.3390/nu17071219 [doi] PST - epublish SO - Nutrients. 2025 Mar 30;17(7):1219. doi: 10.3390/nu17071219. PMID- 40218957 OWN - NLM STAT- MEDLINE DCOM- 20250412 LR - 20250414 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 7 DP - 2025 Mar 29 TI - Food Neophobia: A Common Challenge Among Brazilian Children with Down Syndrome. LID - 10.3390/nu17071199 [doi] LID - 1199 AB - Objective: Food neophobia (FN) is defined as the reluctance to eat new foods. The present study aimed to evaluate FN in Brazilian children with Down syndrome (DS) based on their caregivers' perceptions. Method: This was a descriptive, cross-sectional study. The convenient sample consisted of responses from the caregivers of 231 children aged 4 to 11 years. Recruitment occurred through chain sampling, research, and dissemination via social media profiles, associations, and emails. Caregivers answered sociodemographic questions and the Brazilian Children's Food Neophobia Questionnaire (BCFNeo), an instrument previously developed and validated for the Brazilian context. Data were exported from the Google Form((R)) platform and analyzed using Excel((R)) and SPSS((R)). Descriptive statistics, the independent Student's t-test, the Mann-Whitney U test, and the Friedman test were used, following the methodology indicated by BCFNeo. Results: The results indicated a high FN prevalence rate of 41.1%. The general domain showed the highest prevalence (48.1%). There were no significant differences in FN across age groups (p > 0.05), and boys were more neophobic than girls (p = 0.006). The school environment emerged as a favorable setting to encourage the consumption of new fruits (p < 0.05). Conclusions: Children with DS exhibited similar levels of FN compared to Brazilian neurodiverse children. This study highlights the need for further research into eating behaviors in children with DS and emphasizes the school's role as a space for the promotion of healthy eating habits. FAU - De Almeida, Priscila Claudino AU - De Almeida PC AUID- ORCID: 0000-0001-9871-0112 AD - Graduate Program in Human Nutrition, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Vasconcelos, Ivana Aragao Lira AU - Vasconcelos IAL AUID- ORCID: 0000-0001-6543-7690 AD - Department of Nutrition, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Nakano, Eduardo Yoshio AU - Nakano EY AUID- ORCID: 0000-0002-9071-8512 AD - Department of Statistics, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Zandonadi, Renata Puppin AU - Zandonadi RP AUID- ORCID: 0000-0003-0370-3089 AD - Department of Nutrition, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Botelho, Raquel Braz Assuncao AU - Botelho RBA AUID- ORCID: 0000-0002-0369-287X AD - Department of Nutrition, University of Brasilia, Brasilia 70910-900, Brazil. LA - eng GR - Edital n masculine 001/2025 DPI/BCE/UnB/University of Brasilia/ GR - no number/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ PT - Journal Article DEP - 20250329 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Down Syndrome/psychology MH - Brazil/epidemiology MH - Female MH - Male MH - Child MH - Cross-Sectional Studies MH - Child, Preschool MH - Surveys and Questionnaires MH - *Food Preferences/psychology MH - *Feeding Behavior/psychology MH - Prevalence MH - Caregivers/psychology PMC - PMC11990528 OTO - NOTNLM OT - Down syndrome OT - caregiver perception OT - child OT - food neophobia OT - prevalence COIS- The authors declare no conflicts of interest. EDAT- 2025/04/12 21:55 MHDA- 2025/04/12 21:56 PMCR- 2025/03/29 CRDT- 2025/04/12 01:08 PHST- 2025/03/12 00:00 [received] PHST- 2025/03/25 00:00 [revised] PHST- 2025/03/28 00:00 [accepted] PHST- 2025/04/12 21:56 [medline] PHST- 2025/04/12 21:55 [pubmed] PHST- 2025/04/12 01:08 [entrez] PHST- 2025/03/29 00:00 [pmc-release] AID - nu17071199 [pii] AID - nutrients-17-01199 [pii] AID - 10.3390/nu17071199 [doi] PST - epublish SO - Nutrients. 2025 Mar 29;17(7):1199. doi: 10.3390/nu17071199. PMID- 40218926 OWN - NLM STAT- MEDLINE DCOM- 20250412 LR - 20250414 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 7 DP - 2025 Mar 28 TI - Low Self-Perceived Cooking Skills Are Linked to Greater Ultra-Processed Food Consumption Among Adolescents: The EHDLA Study. LID - 10.3390/nu17071168 [doi] LID - 1168 AB - Introduction: Ultra-processed foods (UPFs) are widely consumed despite their established associations with obesity, cardiovascular diseases, and other metabolic disorders. One potential factor contributing to high UPF consumption is the decline in cooking skills, particularly among younger generations. This study aimed to describe the cooking skill perceptions of a sample of Spanish adolescents to examine the relationship between perceived cooking skills and UPF consumption, and to identify the specific UPF subcategories most associated with perceived cooking skills. Methods: This study is a secondary cross-sectional analysis using data from the Eating Healthy and Daily Life Activities (EHDLA) study, which was conducted among 847 Spanish adolescents (12-17 years) from three secondary schools in Valle de Ricote (Region of Murcia, Spain). The participants' perceptions of their cooking skills were assessed through the following question: "How would you rate your cooking skills?". The response options included (a) very adequate, (b) adequate, (c) inadequate, and (d) very inadequate. UPF consumption was evaluated via a self-administered food frequency questionnaire (FFQ) previously validated for the Spanish population. UPFs were classified according to the NOVA system, which distinguishes four groups: (1) unprocessed or minimally processed foods; (2) processed culinary ingredients, such as salt, sugar, and oils, used to enhance the preparation of fresh foods; (3) processed foods; and (4) UPF and drink products. To examine the associations between perceived cooking skills and UPF consumption, marginal means and 95% confidence intervals for servings of individual UPF groups were calculated via generalized linear models. These models were adjusted for age, sex, socioeconomic status, physical activity, sedentary behavior, sleep duration, and body mass index to control for potential confounders. Post hoc comparisons between cooking skill categories were conducted via false discovery rate correction following the Benjamini-Hochberg procedure, with significance set at p < 0.05. Results: Most participants (47%) rated their cooking skills as adequate (47%) or very adequate (18%). Overall UPF intake showed a decreasing trend across skill levels, with the "very adequate" group consuming significantly fewer servings than the "very inadequate" group did (p = 0.015). Among the specific UPF categories, adolescents in the "very adequate" category consumed significantly fewer sweets than those in the "very inadequate" and "inadequate" categories did (p < 0.05 for all). Conclusions: This study revealed evidence of a relationship between cooking skills and overall UPF intake. These results support the importance of interventions that promote cooking competencies among adolescents. School-based culinary programs and community initiatives that teach adolescents simple, time-efficient, and cost-effective cooking techniques could help reduce the overall intake of UPFs. FAU - Hermosa-Bosano, Carlos AU - Hermosa-Bosano C AUID- ORCID: 0000-0001-7957-2455 AD - Well-Being, Health, and Society Research Group, Universidad de Las Americas, Quito 170513, Ecuador. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AUID- ORCID: 0000-0002-7412-7624 AD - Department of Communication and Education, Universidad Loyola Andalucia, 41704 Seville, Spain. LA - eng PT - Journal Article DEP - 20250328 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - *Cooking MH - Cross-Sectional Studies MH - *Fast Foods MH - Spain MH - Child MH - *Feeding Behavior MH - *Self Concept MH - *Adolescent Behavior MH - Food, Processed PMC - PMC11990398 OTO - NOTNLM OT - cooking OT - cooking skills OT - culinary competence OT - diet quality OT - ultra-processed foods COIS- The authors declare no conflicts of interest. EDAT- 2025/04/12 21:54 MHDA- 2025/04/12 21:55 PMCR- 2025/03/28 CRDT- 2025/04/12 01:08 PHST- 2025/02/25 00:00 [received] PHST- 2025/03/06 00:00 [revised] PHST- 2025/03/24 00:00 [accepted] PHST- 2025/04/12 21:55 [medline] PHST- 2025/04/12 21:54 [pubmed] PHST- 2025/04/12 01:08 [entrez] PHST- 2025/03/28 00:00 [pmc-release] AID - nu17071168 [pii] AID - nutrients-17-01168 [pii] AID - 10.3390/nu17071168 [doi] PST - epublish SO - Nutrients. 2025 Mar 28;17(7):1168. doi: 10.3390/nu17071168. PMID- 40218919 OWN - NLM STAT- MEDLINE DCOM- 20250421 LR - 20250421 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 7 DP - 2025 Mar 27 TI - Erythrocyte Fatty Acid Profile, Mediterranean Diet and Asthma Severity in Childhood Allergic Asthma: Preliminary Findings from a Cohort Study in Spain. LID - 10.3390/nu17071161 [doi] LID - 1161 AB - Background: Allergic asthma incidence is increasing, probably due to the influence of the Western diet. Adherence to the Mediterranean diet (MedDi) and omega-3 fatty acids composition (n-3 PUFAs) may be linked to a lower prevalence and lower severity of childhood asthma; however, the association is inconclusive. This study aims to examine the relationship between adherence to the MedDi, asthma severity, and erythrocyte fatty acid profile in Spanish children with atopic asthma. Methods: This study was based on an ongoing single-center, prospective, cross-sectional cohort study involving 95 consecutively enrolled children from an outpatient tertiary referral center. Of these, 55 had atopic asthma and 40 were age-matched healthy controls. Blood samples were collected to analyze the erythrocyte fatty acid content. Participants' demographic and clinical characteristics were recorded using validated self-reported outcome measures. Asthma severity and pulmonary function were assessed. Results: Asthmatics presented poorer adherence to the MedDi (p = 0.034) and lower n-3 PUFA levels (p = 0.019). Asthmatics with poor adherence to the MedDi were more likely to be overweight (p = 0.001) and to have moderate-severe asthma (p = 0.049); and lower n-3 PUFAs levels (p = 0.033). Children with mild asthma had higher n-3 PUFAs levels than those with moderate or severe asthma (p = 0.036). Conclusions: These findings highlight that adherence to the MedDi and a high erythrocyte fatty acid profile seem to have a protective effect in childhood asthma. Future well-controlled interventions should focus on the effects of MedDi patterns and n-3 PUFA intake on the primary prevention of childhood asthma. FAU - Ayats-Vidal, Roser AU - Ayats-Vidal R AUID- ORCID: 0000-0002-5245-9847 AD - Pediatric Pneumology Unit, Pediatric Medicine Service, Hospital Sant Joan de Deu, 08950 Barcelona, Spain. AD - Pediatric Allergies, Immunology and Pneumology Unit, Pediatric Medicine Service, Institut d'Investigacio i Innovacio Parc Tauli (I3PT-CERCA), Parc Tauli Hospital Universitari, Universitat Autonoma de Barcelona, 08208 Sabadell, Spain. FAU - Albiciuc, Isabela-Adelina AU - Albiciuc IA AD - Pediatric Allergies, Immunology and Pneumology Unit, Pediatric Medicine Service, Institut d'Investigacio i Innovacio Parc Tauli (I3PT-CERCA), Parc Tauli Hospital Universitari, Universitat Autonoma de Barcelona, 08208 Sabadell, Spain. FAU - Bruch-Molist, Carlota AU - Bruch-Molist C AD - Pediatric Allergies, Immunology and Pneumology Unit, Pediatric Medicine Service, Institut d'Investigacio i Innovacio Parc Tauli (I3PT-CERCA), Parc Tauli Hospital Universitari, Universitat Autonoma de Barcelona, 08208 Sabadell, Spain. FAU - Cuartero-Gorjon, Anna AU - Cuartero-Gorjon A AUID- ORCID: 0009-0005-0593-0914 AD - Pediatric Allergies, Immunology and Pneumology Unit, Pediatric Medicine Service, Institut d'Investigacio i Innovacio Parc Tauli (I3PT-CERCA), Parc Tauli Hospital Universitari, Universitat Autonoma de Barcelona, 08208 Sabadell, Spain. FAU - Cordobilla, Begona AU - Cordobilla B AUID- ORCID: 0000-0002-0418-9387 AD - Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain. FAU - Pedrosa-Dominguez, Marina AU - Pedrosa-Dominguez M AUID- ORCID: 0009-0000-0209-2517 AD - Pediatric Allergies, Immunology and Pneumology Unit, Pediatric Medicine Service, Institut d'Investigacio i Innovacio Parc Tauli (I3PT-CERCA), Parc Tauli Hospital Universitari, Universitat Autonoma de Barcelona, 08208 Sabadell, Spain. FAU - Susanna-Calero, Marta AU - Susanna-Calero M AD - Pediatric Allergies, Immunology and Pneumology Unit, Pediatric Medicine Service, Institut d'Investigacio i Innovacio Parc Tauli (I3PT-CERCA), Parc Tauli Hospital Universitari, Universitat Autonoma de Barcelona, 08208 Sabadell, Spain. FAU - Garcia-Gonzalez, Miguel AU - Garcia-Gonzalez M AD - Pediatric Allergies, Immunology and Pneumology Unit, Pediatric Medicine Service, Institut d'Investigacio i Innovacio Parc Tauli (I3PT-CERCA), Parc Tauli Hospital Universitari, Universitat Autonoma de Barcelona, 08208 Sabadell, Spain. FAU - Valdesoiro-Navarrete, Laura AU - Valdesoiro-Navarrete L AD - Pediatric Allergies, Immunology and Pneumology Unit, Pediatric Medicine Service, Institut d'Investigacio i Innovacio Parc Tauli (I3PT-CERCA), Parc Tauli Hospital Universitari, Universitat Autonoma de Barcelona, 08208 Sabadell, Spain. FAU - Larramona-Carrera, Helena AU - Larramona-Carrera H AD - Pediatric Allergies, Immunology and Pneumology Unit, Pediatric Medicine Service, Institut d'Investigacio i Innovacio Parc Tauli (I3PT-CERCA), Parc Tauli Hospital Universitari, Universitat Autonoma de Barcelona, 08208 Sabadell, Spain. FAU - Asensio-de la Cruz, Oscar AU - Asensio-de la Cruz O AD - Pediatric Allergies, Immunology and Pneumology Unit, Pediatric Medicine Service, Institut d'Investigacio i Innovacio Parc Tauli (I3PT-CERCA), Parc Tauli Hospital Universitari, Universitat Autonoma de Barcelona, 08208 Sabadell, Spain. FAU - Castro-Marrero, Jesus AU - Castro-Marrero J AUID- ORCID: 0000-0002-2481-3052 AD - Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain. AD - Division of Rheumatology, Research Unit in ME/CFS and Long COVID, Vall d'Hebron Hospital Research Institute, Universitat Autonoma de Barcelona, 08042 Barcelona, Spain. FAU - Domingo, Joan Carles AU - Domingo JC AUID- ORCID: 0000-0002-6356-0836 AD - Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain. LA - eng GR - 2022 SEICAP/Spanish Society of Clinical Immunology, Allergology and Pediatric Asthma/ PT - Journal Article DEP - 20250327 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Fatty Acids, Omega-3) SB - IM MH - *Diet, Mediterranean/statistics & numerical data MH - *Asthma/blood/diagnosis/diet therapy/immunology MH - *Erythrocytes/metabolism MH - Severity of Illness Index MH - Prospective Studies MH - Cross-Sectional Studies MH - Tertiary Care Centers MH - Patient Compliance/statistics & numerical data MH - *Fatty Acids, Omega-3/administration & dosage/blood/metabolism MH - Spain/epidemiology MH - Overweight/epidemiology MH - Humans MH - Male MH - Female MH - Child MH - Adolescent PMC - PMC11990728 OTO - NOTNLM OT - PUFAs OT - asthma OT - erythrocyte fatty acids OT - inflammation OT - mediterranean diet OT - omega-3 index COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2025/04/12 21:51 MHDA- 2025/04/12 21:52 PMCR- 2025/03/27 CRDT- 2025/04/12 01:08 PHST- 2025/02/18 00:00 [received] PHST- 2025/03/18 00:00 [revised] PHST- 2025/03/25 00:00 [accepted] PHST- 2025/04/12 21:52 [medline] PHST- 2025/04/12 21:51 [pubmed] PHST- 2025/04/12 01:08 [entrez] PHST- 2025/03/27 00:00 [pmc-release] AID - nu17071161 [pii] AID - nutrients-17-01161 [pii] AID - 10.3390/nu17071161 [doi] PST - epublish SO - Nutrients. 2025 Mar 27;17(7):1161. doi: 10.3390/nu17071161. PMID- 40218860 OWN - NLM STAT- MEDLINE DCOM- 20250412 LR - 20250414 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 7 DP - 2025 Mar 21 TI - Empowering Healthy Adolescents: A Dietary Adherence Tool Incorporating Environmental Factors Based on Korean Guidelines. LID - 10.3390/nu17071102 [doi] LID - 1102 AB - Background: Adolescence is a critical period for adopting lifestyle behaviors that influence long-term health. While dietary habits are well-documented, the broader socio-cultural and environmental factors impacting these behaviors are underexplored. This study aimed to develop a dietary adherence tool for adolescents that aligns with the Dietary Guidelines for Koreans, incorporating individual and environmental factors for a comprehensive understanding of dietary behaviors. Methods: A nationwide survey was conducted with 1010 adolescents in Korea to develop and validate a dietary adherence tool based on the Dietary Guidelines for Koreans. Factor analyses and structural equation modeling confirmed the construct validity of the tool, and a grading system was established to evaluate adherence based on survey responses. Results: The survey included participants from 17 regions across South Korea. The original 22 candidate items were revised through factor analysis, resulting in the deletion of 4 items and the addition of 6 new items, leading to a final 24-item tool encompassing three domains: food intake, dietary and physical activity behaviors, and dietary culture. The validity of the revised tool remained intact. The mean dietary guideline adherence score of the participants was 54.5 (SD = 12.1), with domain scores of 39.1 (SD = 14.4) for food intake, 51.6 (SD = 16.6) for dietary and physical activity behaviors, and 66.8 (SD = 15.4) for dietary culture. Conclusions: The dietary adherence tool offers a comprehensive framework for assessing adolescent dietary behaviors by integrating food intake, dietary and physical activity behaviors, and environmental factors. By considering sustainability and family support, it promotes healthier and more sustainable eating patterns among adolescents. FAU - Lim, Jimin AU - Lim J AUID- ORCID: 0000-0002-4554-3880 AD - Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 03760, Republic of Korea. FAU - Lee, Soobin AU - Lee S AD - Department of Clinical Nutrition, Ewha Womans University, Seoul 03760, Republic of Korea. FAU - Hwang, Ji-Yun AU - Hwang JY AUID- ORCID: 0000-0003-4003-1293 AD - Major of Foodservice Management and Nutrition, Sangmyung University, Seoul 03016, Republic of Korea. FAU - Oh, Jieun AU - Oh J AUID- ORCID: 0000-0003-4152-8306 AD - College of Science and Industry Convergence, Ewha Womans University, Seoul 03760, Republic of Korea. LA - eng GR - PJ017088/Rural Development Administration/ PT - Journal Article DEP - 20250321 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - Republic of Korea MH - Male MH - Female MH - *Nutrition Policy MH - *Feeding Behavior MH - Exercise MH - *Diet, Healthy MH - *Adolescent Behavior MH - *Diet MH - Surveys and Questionnaires MH - Reproducibility of Results MH - *Guideline Adherence PMC - PMC11990321 OTO - NOTNLM OT - adherence tool OT - adolescent OT - dietary guidelines for Koreans OT - social support OT - sustainable eating COIS- The authors declare no conflicts of interest. EDAT- 2025/04/12 21:54 MHDA- 2025/04/12 21:55 PMCR- 2025/03/21 CRDT- 2025/04/12 01:08 PHST- 2025/03/04 00:00 [received] PHST- 2025/03/19 00:00 [revised] PHST- 2025/03/19 00:00 [accepted] PHST- 2025/04/12 21:55 [medline] PHST- 2025/04/12 21:54 [pubmed] PHST- 2025/04/12 01:08 [entrez] PHST- 2025/03/21 00:00 [pmc-release] AID - nu17071102 [pii] AID - nutrients-17-01102 [pii] AID - 10.3390/nu17071102 [doi] PST - epublish SO - Nutrients. 2025 Mar 21;17(7):1102. doi: 10.3390/nu17071102. PMID- 40218857 OWN - NLM STAT- MEDLINE DCOM- 20250412 LR - 20250414 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 7 DP - 2025 Mar 21 TI - Association Between Increased Dietary Sodium Intake and Higher Water Intake from Fluid and Food in Children. LID - 10.3390/nu17071099 [doi] LID - 1099 AB - Background and Objectives: Maintaining an appropriate hydration status is crucial for promoting health. Children, who are in the process of growth and development, are at a higher risk of insufficient water intake and dehydration. This study aimed to compare water intake among children with different levels of dietary sodium intake, and explore the relationship between hydration status, and dietary sodium intake and water intake. Methods: In this cross-sectional survey, 155 students in grades 4-6 from a primary school in Binyang County, Nanning, Guangxi, were recruited. Water intake from fluid was assessed using a validated 7-Day 24 h Fluid Intake Survey Questionnaire (days 1-7). Food intake was recorded and weighed using the duplicate diet method on days 5, 6, and 7. The water content in food was determined using the direct drying method, and dietary sodium intake was measured using inductively coupled plasma-optical emission spectrometry (ICP-OES). Urine osmolality was measured at two time points (morning and before afternoon classes) on days 5, 6, and 7 to assess hydration status. Results: A total of 155 participants (87 boys and 68 girls) completed the study, with a completion rate of 100%. The average dietary sodium intake, total water intake (TWI), water intake from fluid, and water intake from food were 1647 mg, 2039 mL, 956 mL, and 1175 mL, respectively. Among the participants, 19.4% exceeded the recommended sodium intake (2000 mg/day), 41.9% did not meet the adequate daily water intake from fluid, and 63.2% did not meet the adequate daily total water intake. When participants were divided into quartiles based on dietary sodium intake, significant differences were observed in water intake from fluid (p = 0.031) and food (p < 0.001). The water intake from fluid among participants in the HS1 (982 mL) and HS2 groups (997 mL) was higher than that among participants in LS2 (759 mL). Water intake from food increased progressively with increasing sodium intake (851 mL, 1075 mL, 1224 mL, and 1550 mL). Urine osmolality was associated with meeting the daily adequate water intake from fluid (p = 0.006), but not with exceeding the sodium intake standard (p = 0.787). There was no interaction between meeting the daily adequate water intake from fluid and exceeding the sodium intake standard (p = 0.413). Conclusions: Insufficient water intake was common among children. Children with a higher dietary sodium intake had a higher water intake from fluid and food. Urine osmolality was closely related to daily water intake from fluid, but not to sodium intake. FAU - Zhang, Yi AU - Zhang Y AUID- ORCID: 0009-0000-9485-1671 AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing 100191, China. FAU - Song, Yongye AU - Song Y AUID- ORCID: 0000-0001-8668-1828 AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing 100191, China. FAU - Cheng, Shuai AU - Cheng S AD - National Center for Rural Water Supply Technical Guidance, Chinese Center for Disease Control and Prevention, Beijing 102200, China. FAU - Xia, Yunting AU - Xia Y AD - National Center for Rural Water Supply Technical Guidance, Chinese Center for Disease Control and Prevention, Beijing 102200, China. FAU - Li, Hongxing AU - Li H AUID- ORCID: 0000-0001-6530-6711 AD - National Center for Rural Water Supply Technical Guidance, Chinese Center for Disease Control and Prevention, Beijing 102200, China. FAU - Huang, Jiangping AU - Huang J AD - Institute of Environmental Hygiene and Endemic Disease Control, Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning 530028, China. FAU - Xu, Luxi AU - Xu L AD - Institute of Environmental Hygiene and Endemic Disease Control, Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning 530028, China. FAU - Zhang, Na AU - Zhang N AUID- ORCID: 0000-0001-7713-5980 AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing 100191, China. AD - Laboratory of Toxicological Research and Risk Assessment for Food Safety, Peking University, 38 Xue Yuan Road, Haidian District, Beijing 100191, China. LA - eng GR - 2023-11, 2024-09/World Vision International/ GR - 2023-11, 2024-09/Chinese Center For Disease Control and Prevention/ PT - Journal Article DEP - 20250321 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Sodium, Dietary) SB - IM MH - Humans MH - Female MH - Male MH - *Drinking/physiology MH - Cross-Sectional Studies MH - Child MH - *Sodium, Dietary/administration & dosage MH - Dehydration/etiology MH - China MH - Osmolar Concentration MH - *Eating/physiology PMC - PMC11990302 OTO - NOTNLM OT - children OT - hydration status OT - sodium intake OT - water intake from fluid OT - water intake from food COIS- The authors declare no conflicts of interest. EDAT- 2025/04/12 21:54 MHDA- 2025/04/12 21:55 PMCR- 2025/03/21 CRDT- 2025/04/12 01:07 PHST- 2025/02/23 00:00 [received] PHST- 2025/03/14 00:00 [revised] PHST- 2025/03/18 00:00 [accepted] PHST- 2025/04/12 21:55 [medline] PHST- 2025/04/12 21:54 [pubmed] PHST- 2025/04/12 01:07 [entrez] PHST- 2025/03/21 00:00 [pmc-release] AID - nu17071099 [pii] AID - nutrients-17-01099 [pii] AID - 10.3390/nu17071099 [doi] PST - epublish SO - Nutrients. 2025 Mar 21;17(7):1099. doi: 10.3390/nu17071099. PMID- 40218154 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250415 IS - 2075-4418 (Print) IS - 2075-4418 (Electronic) IS - 2075-4418 (Linking) VI - 15 IP - 7 DP - 2025 Mar 21 TI - From Genes to Treatment: Literature Review and Perspectives on Acid Sphingomyelinase Deficiency in Children. LID - 10.3390/diagnostics15070804 [doi] LID - 804 AB - Background: Acid sphingomyelinase deficiency (ASMD), most commonly known as Niemann-Pick disease (NPD), is a rare progressive genetic disorder regarding lipid storage. Subtypes A and B are inherited in an autosomal recessive fashion and consist of a genetic defect which affects the sphingomyelin phosphodiesterase 1 gene, leading to residual or lack of enzymatic activity of acid sphingomyelinase (ASM). Materials and Methods: This paper provides a brief history and overview to date of the disease and a comprehensive review of the current literature on ASMD in children, conducted on published papers from the past 10 years. Results: We identified 19 original publications (16 individual case reports and three series of cases-30 patients). The male/female ratio was 1.4. The youngest patient at disease onset was a female newborn with NPD-A. The youngest patient was diagnosed at 4 months. The longest timeframe between onset symptoms and diagnostic moment was 5 years 3 months. A total of nine patients exhibited red cherry macular spots. A total of 13 children exhibited associated lung disease, and four NPD-A patients with pulmonary disease died due to respiratory complications. A total of 11 children exhibited associated growth impairment. Genetic assays were performed in 25 cases (15 homozygous; 9 heterozygous). A total of four children (13.3%) received enzyme replacement therapy (ERT). Therapy outcomes included decreased liver and spleen volumes, improved platelet and leukocytes counts, and body mass index and stature improvement. Conclusions: Sometimes, a small child with a big belly hides a huge dilemma; inherited metabolic disorders are here to challenge clinicians and set the record straight, and genetics is the way of the future in terms of diagnosis and novel treatments. NPD must be considered children with persistent and progressive hepatosplenomegaly and growth failure. Diagnosis requires good clinical skills and access to genetic assays. Since 2022, the FDA has given a green light to a revolutionary enzymatic replacement therapy with human recombinant ASM called Olipudase-alfa. Clinical trial outcomes support its reliability and efficacy in the pediatric population. FAU - Vlad, Raluca Maria AU - Vlad RM AUID- ORCID: 0009-0002-9397-552X AD - Department of Paediatrics, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania. AD - "Grigore Alexandrescu" Emergency Children's Hospital, Bld. Iancu de Hunedoara 30-32 Bucharest, 011743 Bucharest, Romania. FAU - Dobritoiu, Ruxandra AU - Dobritoiu R AD - Department of Paediatrics, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania. AD - "Grigore Alexandrescu" Emergency Children's Hospital, Bld. Iancu de Hunedoara 30-32 Bucharest, 011743 Bucharest, Romania. FAU - Pacurar, Daniela AU - Pacurar D AUID- ORCID: 0000-0002-8604-8691 AD - Department of Paediatrics, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania. AD - "Grigore Alexandrescu" Emergency Children's Hospital, Bld. Iancu de Hunedoara 30-32 Bucharest, 011743 Bucharest, Romania. LA - eng PT - Journal Article PT - Review DEP - 20250321 PL - Switzerland TA - Diagnostics (Basel) JT - Diagnostics (Basel, Switzerland) JID - 101658402 PMC - PMC11988438 OTO - NOTNLM OT - Niemann-Pick OT - acid sphingomyelinase deficiency OT - enzyme replacement therapy OT - metabolic disorder OT - sphingomyelin COIS- The authors declare no conflicts of interest. EDAT- 2025/04/12 21:52 MHDA- 2025/04/12 21:53 PMCR- 2025/03/21 CRDT- 2025/04/12 01:04 PHST- 2025/02/15 00:00 [received] PHST- 2025/03/17 00:00 [revised] PHST- 2025/03/17 00:00 [accepted] PHST- 2025/04/12 21:53 [medline] PHST- 2025/04/12 21:52 [pubmed] PHST- 2025/04/12 01:04 [entrez] PHST- 2025/03/21 00:00 [pmc-release] AID - diagnostics15070804 [pii] AID - diagnostics-15-00804 [pii] AID - 10.3390/diagnostics15070804 [doi] PST - epublish SO - Diagnostics (Basel). 2025 Mar 21;15(7):804. doi: 10.3390/diagnostics15070804. PMID- 40217907 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250415 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 14 IP - 7 DP - 2025 Apr 3 TI - Psychometric Evaluation of the Polish Language Version of the Sleep Disturbance Scale for Children (SDSC)-A Pilot Study. LID - 10.3390/jcm14072458 [doi] LID - 2458 AB - Sleep disorders in children and adolescents are common, affecting approximately 25-50% of children worldwide, yet they remain insufficiently researched. These sleep abnormalities, especially during developmental stages, can lead to various consequences, including emotional and behavioral disorders, academic challenges, mood disorders, and metabolic issues such as obesity. Background/Objectives: The study aimed to psychometrically evaluate a tool for examining sleep disorders in Polish children. Methods: The study involved a randomly selected sample of 42 children, all aged 10, from two primary schools in Poland: one located in a city with over 100,000 inhabitants and the other in a smaller town. Parents were asked to complete the Sleep Disturbance Scale for Children (SDSC) along with a sociodemographic survey. The study assessed reliability using Cronbach's alpha (alpha) and evaluated the correlation between individual domains using Spearman's rank correlation coefficient (Rs). Results: The pilot group demonstrated very good internal consistency for the entire SDSC scale, with a Cronbach's alpha value of 0.89, and suitable values for the individual subscales (ranging from 0.69 to 0.83). Additionally, there was a positive correlation between the individual subscales. Conclusions: While this pilot study requires validation with a larger patient group, the results suggest that the SDSC scale could be an effective tool for screening sleep disorders among Polish children. FAU - Jaczak-Gozdziak, Malgorzata AU - Jaczak-Gozdziak M AUID- ORCID: 0000-0001-7270-9631 AD - Department of Developmental Neurology, Poznan University of Medical Sciences, 61-701 Poznan, Poland. FAU - Bruni, Oliviero AU - Bruni O AUID- ORCID: 0000-0003-2207-1398 AD - Department of Developmental and Social Psychology, Sapienza University of Rome, 00185 Rome, Italy. FAU - Zarowski, Marcin AU - Zarowski M AUID- ORCID: 0000-0002-9800-9446 AD - Department of Developmental Neurology, Poznan University of Medical Sciences, 61-701 Poznan, Poland. LA - eng PT - Journal Article DEP - 20250403 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC11989841 OTO - NOTNLM OT - Polish validation of SDSC OT - SDSC scale OT - sleep disorders COIS- The authors declare no conflicts of interest. EDAT- 2025/04/12 21:52 MHDA- 2025/04/12 21:53 PMCR- 2025/04/03 CRDT- 2025/04/12 01:02 PHST- 2025/03/06 00:00 [received] PHST- 2025/03/24 00:00 [revised] PHST- 2025/04/01 00:00 [accepted] PHST- 2025/04/12 21:53 [medline] PHST- 2025/04/12 21:52 [pubmed] PHST- 2025/04/12 01:02 [entrez] PHST- 2025/04/03 00:00 [pmc-release] AID - jcm14072458 [pii] AID - jcm-14-02458 [pii] AID - 10.3390/jcm14072458 [doi] PST - epublish SO - J Clin Med. 2025 Apr 3;14(7):2458. doi: 10.3390/jcm14072458. PMID- 40217548 OWN - NLM STAT- MEDLINE DCOM- 20250412 LR - 20250414 IS - 1479-5868 (Electronic) IS - 1479-5868 (Linking) VI - 22 IP - 1 DP - 2025 Apr 11 TI - Flexible or rigid control of eating scale: development and validation of the FORCES in women. PG - 45 LID - 10.1186/s12966-025-01746-3 [doi] LID - 45 AB - BACKGROUND: Many dieters show a pattern of disinhibited eating following a diet violation, and it has been proposed that the nature of their dietary restraint (i.e., whether they are rigid or flexible in their pursuit of dietary control) could prove beneficial in explaining variability in the occurrence of disinhibited eating. However, existing measures of rigid and flexible control do not adequately separate these two styles of dietary restraint. METHOD: The current studies aim to develop a new scale that more clearly differentiates the constructs of rigid and flexible control of eating. Exploratory and confirmatory factor analysis were used to develop and validate the new scale across three distinct samples of women (total N = 1048). RESULTS: Factor analysis identified five total factors: three relating to the rigid control of food intake (Strict Behaviours, Negative Emotions, and Worry), and two relating to the flexible control of food intake (Flexible Beliefs and Positive Emotions). The Flexible or Rigid Control of Eating Scale (FORCES) had good internal consistency, a reliable factor structure that replicated across the three samples of women and provided a clear separation between rigid and flexible control. CONCLUSIONS: The FORCES may allow researchers to explain why some dieters are more likely to engage in disinhibited eating than are others and can be a beneficial step toward addressing the negative consequences of maladaptive dieting behaviour. CI - (c) 2025. The Author(s). FAU - Nicholls, Kate AU - Nicholls K AD - School of Psychology, Faculty of Science, UNSW Sydney, High Street Kensington, Sydney, NSW, 2052, Australia. kate.nicholls@unsw.edu.au. FAU - Vartanian, Lenny R AU - Vartanian LR AD - School of Psychology, Faculty of Science, UNSW Sydney, High Street Kensington, Sydney, NSW, 2052, Australia. FAU - Faasse, Kate AU - Faasse K AD - School of Psychology, Faculty of Science, UNSW Sydney, High Street Kensington, Sydney, NSW, 2052, Australia. FAU - Mills, Jennifer S AU - Mills JS AD - Department of Psychology, Faculty of Health, York University, Toronto, Canada. LA - eng PT - Journal Article PT - Validation Study DEP - 20250411 PL - England TA - Int J Behav Nutr Phys Act JT - The international journal of behavioral nutrition and physical activity JID - 101217089 SB - IM MH - Humans MH - Female MH - *Feeding Behavior/psychology MH - Adult MH - Factor Analysis, Statistical MH - Middle Aged MH - Young Adult MH - *Eating/psychology MH - Surveys and Questionnaires MH - Reproducibility of Results MH - *Diet/psychology MH - Emotions MH - Adolescent PMC - PMC11992708 OTO - NOTNLM OT - Dietary restraint OT - Disinhibition OT - Flexible control OT - Rigid control OT - Scale development COIS- Declarations. Ethics approval and consent to participate: This set of studies received ethical approval from the UNSW HREAP-C (File 3654). All participants provided electronic informed consent. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/04/12 00:42 MHDA- 2025/04/12 21:55 PMCR- 2025/04/11 CRDT- 2025/04/11 23:59 PHST- 2024/10/22 00:00 [received] PHST- 2025/04/03 00:00 [accepted] PHST- 2025/04/12 21:55 [medline] PHST- 2025/04/12 00:42 [pubmed] PHST- 2025/04/11 23:59 [entrez] PHST- 2025/04/11 00:00 [pmc-release] AID - 10.1186/s12966-025-01746-3 [pii] AID - 1746 [pii] AID - 10.1186/s12966-025-01746-3 [doi] PST - epublish SO - Int J Behav Nutr Phys Act. 2025 Apr 11;22(1):45. doi: 10.1186/s12966-025-01746-3. PMID- 40217324 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250413 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 13 IP - 1 DP - 2025 Apr 11 TI - United States-based practice guidelines for children and adolescents with eating disorders : Synthesis of clinical practice guidelines. PG - 66 LID - 10.1186/s40337-025-01254-6 [doi] LID - 66 AB - INTRODUCTION: Several practice guidelines exist from professional organizations in the United States to support the assessment and management of eating disorders in children and adolescents. This manuscript synthesizes the key areas of overlap from these guidelines and provides directions for future research and alignment to improve care. RECOMMENDATIONS: Consistent screening for eating disorders in primary care is recommended to ensure early identification and referral to treatment. Outpatient treatment supported by families, including family based treatment, is the first line of care recommended by guidelines. Multidisciplinary treatment teams benefit patients in covering the variety of aspects of health that eating disorders impact, including mental health, nutritional health, and physical health. Patients may require hospitalization under certain medical criteria such as bradycardia or specific lab abnormalities. CONCLUSIONS: Guidelines show consensus on the importance of early identification and treatment access, involvement of family in treatment, and the use of a multidisciplinary treatment team. However, future work is needed to guide care of Avoidant/Restrictive Food Intake Disorder (ARFID), as well as the impact of weight inclusive care and the development of validated screening tools for children and adolescents for all eating disorders. CI - (c) 2025. The Author(s). FAU - Bohon, Cara AU - Bohon C AD - Equip Health, Carlsbad, CA, USA. cara@equip.health. AD - Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA. cara@equip.health. FAU - Le Grange, Daniel AU - Le Grange D AD - Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA. AD - Department of Psychiatry and Behavioral Neuroscience (Emeritus), The University of Chicago, Chicago, IL, USA. FAU - Attia, Evelyn AU - Attia E AD - Department of Psychiatry, Columbia University Medical Center, New York, NY, USA. AD - Department of Psychiatry, Weill Cornell Medical College, New York, NY, USA. FAU - Golden, Neville H AU - Golden NH AD - Department of Pediatrics, Division of Adolescent Medicine, Stanford University, Stanford, CA, USA. FAU - Steinberg, Dori AU - Steinberg D AD - Equip Health, Carlsbad, CA, USA. LA - eng PT - Journal Article PT - Review DEP - 20250411 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC11987470 OAB - Several professional organizations in the U.S. provide guidelines for assessing and treating eating disorders in children and adolescents. This paper highlights key areas of agreement across these guidelines and suggests future research directions. OABL- eng OTO - NOTNLM OT - Anorexia nervosa OT - Avoidant/restrictive food intake disorder OT - Binge eating disorder OT - Bulimia nervosa OT - Eating disorders OT - Practice guidelines COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: CB and DS received salary and equity from Equip Health during the preparation of this manuscript. DLG is co-director of the Training Institute for Child and Adolescent Eating Disorders, LLC, receives funding and equity from Equip Health, and receives royalties from Guildford Press and Routledge. EA received equity from Equip Health. EA and NG were members of the APA Practice Guideline Writing Group and NG was an author on the SAHM Guideline. EDAT- 2025/04/12 00:42 MHDA- 2025/04/12 00:43 PMCR- 2025/04/11 CRDT- 2025/04/11 23:50 PHST- 2025/02/18 00:00 [received] PHST- 2025/03/30 00:00 [accepted] PHST- 2025/04/12 00:43 [medline] PHST- 2025/04/12 00:42 [pubmed] PHST- 2025/04/11 23:50 [entrez] PHST- 2025/04/11 00:00 [pmc-release] AID - 10.1186/s40337-025-01254-6 [pii] AID - 1254 [pii] AID - 10.1186/s40337-025-01254-6 [doi] PST - epublish SO - J Eat Disord. 2025 Apr 11;13(1):66. doi: 10.1186/s40337-025-01254-6. PMID- 40215922 OWN - NLM STAT- MEDLINE DCOM- 20250608 LR - 20260304 IS - 1578-8989 (Electronic) IS - 0025-7753 (Linking) VI - 164 IP - 11 DP - 2025 Jun 13 TI - Development of a machine learning model for predicting cardiovascular risk factors and major adverse cardiovascular events in young adults with glucose metabolism disorders. PG - 106911 LID - S0025-7753(25)00105-8 [pii] LID - 10.1016/j.medcli.2025.106911 [doi] AB - BACKGROUND: Glucose metabolism disorders (GMDs) are a serious global public health issue, characterized by a high incidence rate and youthfulness. GMDs contribute to the occurrence of major adverse cardiovascular events (MACEs), meanwhile with the rest of the remaining cardiovascular risk factors (CVRFs) act synergistically to influence MACEs. Although numerous studies have explored CVRFs and their prognostic role in cardiovascular diseases, there is a lack of predictive models for novel cardiovascular risk factors and MACEs in the young population, particularly among patients with GMDS. This study aims to investigate important CVRFs affecting MACEs in young patients with GMDs by means of LASSO regression, randomized forest, and XGBoost, providing new evidence to support the early adoption of proactive and comprehensive interventions and management. METHODS: The study included 411 young patients with GMDs who visit the First People's Hospital of Anqing Affiliated to Anhui Medical University, between September 2022 and June 2023. The patients were randomly divided into a training set and a testing set in a 7:3. Comprehensive analysis was performed using LASSO regression, random forest, and XGBoost methods. The performance of the models was evaluated and validated, and the important cardiovascular risk factors identified by the three models were compared. RESULTS: After one year of follow-up, the incidence of events was higher in men compared to women (85.2% vs. 14.8%). LASSO regression analysis identified BP, TYg, BMI, FBG, and Tg/HDL as significant variables associated with MACEs. The random forest method highlighted BMI, TYg, Tg/HDL, Tg, and FBG as key factors related to MACEs. The XGBoost model also emphasized the important roles of BMI, TYg, TG, and BP. Combining the results from all three models, BMI, TYg, and BP consistently demonstrated significant importance across all models. CONCLUSIONS: To some extent, males are more likely to experience adverse cardiovascular events compared to females. Combining the three major predictive models suggests that traditional CVRFs (BP, BMI) and novel CVRFs (TYg) play an important role in the development of distant MACEs in young GMDs, and that interventions for them may have implications for preventing DM transformation. CI - Copyright (c) 2025 The Authors. Published by Elsevier Espana, S.L.U. All rights reserved. FAU - Zhao, Yangyang AU - Zhao Y AD - Department of Cardiology, The First People's Hospital of Anqing Affiliated to Anhui Medical University, Anqing, China; The Fifth Clinical College of Anhui Medical University, Hefei, China. FAU - Zhang, Wenjing AU - Zhang W AD - Department of Cardiology, The First People's Hospital of Anqing Affiliated to Anhui Medical University, Anqing, China; The Fifth Clinical College of Anhui Medical University, Hefei, China. FAU - Peng, Jiecheng AU - Peng J AD - Department of Cardiology, The First People's Hospital of Anqing Affiliated to Anhui Medical University, Anqing, China. Electronic address: pengjiec@163.com. LA - eng LA - spa PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250410 PL - Spain TA - Med Clin (Barc) JT - Medicina clinica JID - 0376377 SB - IM MH - Humans MH - *Cardiovascular Diseases/etiology/epidemiology MH - Female MH - Male MH - *Machine Learning MH - *Glucose Metabolism Disorders/complications MH - Adult MH - *Heart Disease Risk Factors MH - Young Adult MH - Risk Assessment/methods MH - Risk Factors OTO - NOTNLM OT - Estudio prospectivo de cohortes OT - Eventos cardiovasculares adversos mayores OT - Glucose metabolism disorders OT - Major adverse cardiovascular events OT - Novel cardiovascular risks OT - Nuevos riesgos cardiovasculares OT - Prospective cohort study OT - Trastornos del metabolismo de la glucosa OT - Triglyceride-glucose index OT - Indice triglicerido-glucosa EDAT- 2025/04/12 00:42 MHDA- 2025/06/09 00:28 CRDT- 2025/04/11 18:10 PHST- 2024/08/10 00:00 [received] PHST- 2024/12/08 00:00 [revised] PHST- 2024/12/10 00:00 [accepted] PHST- 2025/06/09 00:28 [medline] PHST- 2025/04/12 00:42 [pubmed] PHST- 2025/04/11 18:10 [entrez] AID - S0025-7753(25)00105-8 [pii] AID - 10.1016/j.medcli.2025.106911 [doi] PST - ppublish SO - Med Clin (Barc). 2025 Jun 13;164(11):106911. doi: 10.1016/j.medcli.2025.106911. Epub 2025 Apr 10. PMID- 40213105 OWN - NLM STAT- MEDLINE DCOM- 20250411 LR - 20250412 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 16 DP - 2025 TI - Development and externally validated prediction model of individualization of FSH starting dose in the depot GnRH agonist protocol for the early follicular phase. PG - 1542736 LID - 10.3389/fendo.2025.1542736 [doi] LID - 1542736 AB - BACKGROUND: Each controlled ovarian hyperstimulation(COH) protocol has its own unique mechanism and hormone pattern. The depot GnRHa protocol has a deeper down-regulation effect and favorable clinical pregnancy rates. The predictive model of the optimal follicle-stimulating hormone (FSH) starting dose in the early follicular phase depot GnRH agonist (EFDGa) protocol has not been reported. Our study was made to explore predictive indicators for determining the optimal FSH starting dose in patients undergoing ovarian stimulation with the EFDGa protocol in assisted reproductive technology (ART), and to develop and validate a nomogram prediction model for the starting dose of FSH. METHODS: This retrospective study included 2733 cycles who underwent fresh cycle transplantation at two large teaching hospitals in China from January to December 2022: center 1 (Reproductive Medicine Center of first affiliated Hospital of Zhengzhou University) provided the data for modelling (n = 938) and internal testing (n = 400), and center 2 (Reproductive Medicine Center of Jiangxi Maternal and Child Health Hospital) provided the data for external testing (n = 1109). Patient demographics, including age, anti-Mullerian hormone (AMH) levels, baseline endocrine profile, and body mass index (BMI), along with information on ovulation stimulation, were collected. Univariate and multivariate linear regression models were used to identify factors influencing the FSH starting dose. A nomogram for the ideal FSH starting dose was developed based on these factors and validated internally and externally. Bland and Altman plots and paired t-tests were conducted to verify the concordance between groups. RESULTS: Multivariate analysis revealed that patient age, BMI, basal FSH, AMH, and antral follicle count (AFC) were indicators of FSH starting dose. The regression model for predicting FSH starting dose was determined as: Initial FSH dose = 62.957 + 1.780*AGE(years) +4.927*BMI (kg/m(2)) +1.417*bFSH (IU/ml) - 1.996*AFC - 48.174*AMH (ng/ml). Bland and Altman analysis showed good agreement in the internal validation (bias: 0.583, SD of bias: 33.07IU, 95%LOA: -69.7 to 68.5IU b). Furthermore, validating the model on external cohort (center 2) confirmed that nomogram prediction model is an accurate predictor of FSH starting dose ((bias: -1.437, SD of bias: 38.28IU; 95%LOA: -80.0 to 77.1IU). CONCLUSIONS: We established a model for effectively predicting the ideal FSH starting dose, with the nomogram model providing an intuitive representation of the data. The predictive model demonstrates practical utility, effectively initiating a proper ovarian response and preventing adverse ovarian reactions or the occurrence of ovarian hyperstimulation syndrome. As more IVF cycles are being generated in the future, this model will be valuable in clinicians using basic parameters to assess proper initial dose of FSH. CI - Copyright (c) 2025 Fan, Ye, Du, Tian and Kong. FAU - Fan, Wenqian AU - Fan W AD - Reproductive Medical Center, Henan Province Key Laboratory for Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. FAU - Ye, Tian AU - Ye T AD - Reproductive Medical Center, Henan Province Key Laboratory for Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. FAU - Du, Linqing AU - Du L AD - Reproductive Medical Center, Henan Province Key Laboratory for Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. FAU - Tian, Lifeng AU - Tian L AD - Reproductive Medicine Center, Jiangxi Maternal and Child Health Hospital, Nangchang, China. FAU - Kong, Huijuan AU - Kong H AD - Reproductive Medical Center, Henan Province Key Laboratory for Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20250327 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 33515-09-2 (Gonadotropin-Releasing Hormone) RN - 9002-68-0 (Follicle Stimulating Hormone) SB - IM MH - Humans MH - Female MH - Adult MH - Retrospective Studies MH - *Ovulation Induction/methods MH - *Gonadotropin-Releasing Hormone/agonists MH - *Follicle Stimulating Hormone/administration & dosage MH - Pregnancy MH - Nomograms MH - *Follicular Phase/drug effects MH - Pregnancy Rate PMC - PMC11983488 OTO - NOTNLM OT - ideal FSH starting dose OT - internal and external validation OT - nonogram model OT - ovarian responsiveness OT - the early follicular phase depot GnRH agonist (EFDGa) protocol COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/04/11 06:25 MHDA- 2025/04/11 12:27 PMCR- 2025/01/01 CRDT- 2025/04/11 05:46 PHST- 2024/12/10 00:00 [received] PHST- 2025/03/11 00:00 [accepted] PHST- 2025/04/11 12:27 [medline] PHST- 2025/04/11 06:25 [pubmed] PHST- 2025/04/11 05:46 [entrez] PHST- 2025/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2025.1542736 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2025 Mar 27;16:1542736. doi: 10.3389/fendo.2025.1542736. eCollection 2025. PMID- 40213103 OWN - NLM STAT- MEDLINE DCOM- 20250411 LR - 20250412 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 16 DP - 2025 TI - Association between Baltic sea diet and healthy Nordic diet index with risk of type 2 diabetes mellitus: a case-control study. PG - 1510427 LID - 10.3389/fendo.2025.1510427 [doi] LID - 1510427 AB - BACKGROUNDS: Recent evidence shows the beneficial effects of Baltic Sea diet score (BSDS) and healthy Nordic diet index (HNDI) on chronic diseases; however, there is no evidence to investigate them on the risk of type 2 diabetes mellitus (T2DM). The purpose of this study was to investigate the associations between BSDS and HNDI with the risk of T2DM. METHODS: This study used a case-control design with participants aged 18 to 60 diagnosed with type 2 diabetes in the last six months (225 cases, 450 controls). The evaluation of BSDS and HNDI employed a validated 168-item semi-quantitative food frequency questionnaire (FFQ). Binary logistic regression was used to determine how OBS and T2DM are related. RESULTS: The mean scores for the BSDS and HNDI were 16.00 +/- 2.49 and 11.99 +/- 2.61, respectively. The final model, which accounted for confounding variables, indicated that increased adherence to the HNDI is associated with a reduced likelihood of developing T2DM (OR = 0.42; 95% CI 0.18-0.98; p for trend = 0.043). Additionally, a significant association was observed between lower likelihood of T2DM and higher BSDS scores in both unadjusted (OR = 0.49, 95% CI 0.31-0.77; p for trend = 0.001) and adjusted (OR = 0.48, 95% CI 0.32-0.89; p for trend = 0.003) models. CONCLUSION: Our research shows that following a Nordic diet significantly reduces the risk of T2DM. Commitment to this dietary pattern may also reduce related risk factors. Further longitudinal studies across diverse populations are needed to validate these findings. CI - Copyright (c) 2025 Abdelgawwad El-Sehrawy, Jawad, Hammood, Ballal, Srivastava, Sani Mohammed, Arya, Kalia, Kadhim Ahmed and Kareem. FAU - Abdelgawwad El-Sehrawy, Amr Ali Mohamed AU - Abdelgawwad El-Sehrawy AAM AD - Diabetes Endocrinology and Metabolism, Internal Medicine, Diabetes, Endocrinology and Metabolism University, Mansoura University, Mansoura, Egypt. FAU - Jawad, Mahmood AU - Jawad M AD - Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq. FAU - Hammood, Yasir Mohammed AU - Hammood YM AD - College of Physical Education and Sport Science, Almaarif University, Anbar, Iraq. FAU - Ballal, Suhas AU - Ballal S AD - Department of Chemistry and Biochemistry, School of Sciences, Jain University, Bangalore, Karnataka, India. FAU - Srivastava, Manish AU - Srivastava M AD - Department of Endocrinology, National Institute of Medical Sciences, NIMS University Rajasthan, Jaipur, India. FAU - Sani Mohammed, Jaafaru AU - Sani Mohammed J AD - Medical Analysis Department, Faculty of Applied Science, Tishk International University, Erbil, Iraq. FAU - Arya, Renu AU - Arya R AD - Chandigarh Pharmacy College, Chandigarh Group of Colleges-Jhanjeri, Mohali, Punjab, India. FAU - Kalia, Rishiv AU - Kalia R AD - Centre for Research Impact and Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, Punjab, India. FAU - Kadhim Ahmed, Jawad AU - Kadhim Ahmed J AD - Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq. FAU - Kareem, Muthena AU - Kareem M AD - Department of Medical Analysis, Medical Laboratory Technique College, The Islamic University, Najaf, Iraq. AD - Department of Medical Analysis, Medical Laboratory Technique College, the Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq. AD - Department of Medical Analysis, Medical Laboratory Technique College, the Islamic University of Babylon, Babylon, Iraq. LA - eng PT - Journal Article DEP - 20250327 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/epidemiology/prevention & control MH - Male MH - Middle Aged MH - Case-Control Studies MH - Adult MH - Female MH - *Diet, Healthy MH - Young Adult MH - Risk Factors MH - Adolescent MH - Surveys and Questionnaires PMC - PMC11983394 OTO - NOTNLM OT - Baltic Sea diet OT - T2DM OT - dietary indices OT - healthy Nordic diet index OT - type 2 diabetes mellitus COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/04/11 06:25 MHDA- 2025/04/11 12:28 PMCR- 2025/01/01 CRDT- 2025/04/11 05:46 PHST- 2024/10/12 00:00 [received] PHST- 2025/03/03 00:00 [accepted] PHST- 2025/04/11 12:28 [medline] PHST- 2025/04/11 06:25 [pubmed] PHST- 2025/04/11 05:46 [entrez] PHST- 2025/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2025.1510427 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2025 Mar 27;16:1510427. doi: 10.3389/fendo.2025.1510427. eCollection 2025. PMID- 40212721 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250412 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - Evaluating the impact of an oral nutrition supplement on biochemical profile, growth, and body composition in Indian children: an in-silico study. PG - 1519756 LID - 10.3389/fnut.2025.1519756 [doi] LID - 1519756 AB - BACKGROUND: In-silico modeling provides a valuable approach for predicting the effects of nutritional interventions on child growth, particularly in settings where large-scale human trials are challenging. Validated, population-level predictive platforms optimize dosing and intervention strategies, facilitating the development of targeted nutritional approaches that enhance growth outcomes in children. OBJECTIVE: This study aims to assess the impact of an oral nutrition supplement (ONS) intervention on biochemical and growth parameters of Indian children using an in-silico intervention approach. METHODS: An energetics-based modeling framework was developed to simulate the growth trajectories of children aged 6-16 years, integrating national datasets for Indian children. The model, validated with published literature, was designed to predict the effects of nutritional interventions. This study evaluated the impact of two Horlicks Oral Nutrition Supplement (ONS) formulations with varying micronutrient dosages on key growth outcomes. Various intervention scenarios were simulated, including comparisons of ONS with water vs. milk, and interventions with different nutrient compositions, such as macronutrients alone or a combination of macro- and micronutrients. The primary outcomes of the study focused on both biochemical and physical growth changes. Key serum nutrient levels were analyzed, alongside anthropometric measures such as height, weight, and body composition indicators, including fat-free mass, fat mass, and bone mineral content, over simulated periods of 4, 8, and 12 months. RESULTS: The in-silico analysis predicted that two servings of Horlicks with milk significantly improved anthropometric and body composition parameters compared to both milk alone and other experimental groups. Biochemically, the Horlicks intervention led to notable increases in serum nutrient levels, which correlated with higher growth velocities and enhanced body composition relative to plain milk. The model underscored the critical role of combined macro- and micronutrient supplementation, with two servings yielding more pronounced effects than one. CONCLUSION: This study provides important insights into the potential benefits of Horlicks interventions for enhancing child growth outcomes. It underscores the effectiveness of computational models in the preliminary assessment of nutrition interventions, providing foundation for targeted clinical studies to improve child health and development. However, it is important to note that the model benchmarking was conducted using data from the Indian population, and the findings may not be directly applicable to other ethnicities without further validation. CI - Copyright (c) 2025 Sringari, Vijaykumar, Sherkane, Venkatesh, Gupta, Lomore and Venkatesh. FAU - Sringari, Sahana AU - Sringari S AD - MetFlux Research Private Limited, Bengaluru, India. FAU - Vijaykumar, Surabhi AU - Vijaykumar S AD - MetFlux Research Private Limited, Bengaluru, India. FAU - Sherkane, Manali AU - Sherkane M AD - MetFlux Research Private Limited, Bengaluru, India. FAU - Venkatesh, Megha AU - Venkatesh M AD - MetFlux Research Private Limited, Bengaluru, India. FAU - Gupta, Suranjana AU - Gupta S AD - MetFlux Research Private Limited, Bengaluru, India. FAU - Lomore, Karan AU - Lomore K AD - MetFlux Research Private Limited, Bengaluru, India. FAU - Venkatesh, K V AU - Venkatesh KV AD - MetFlux Research Private Limited, Bengaluru, India. AD - Department of Chemical Engineering, Institute of Technology Bombay, Mumbai, India. LA - eng PT - Journal Article DEP - 20250327 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC11983558 OTO - NOTNLM OT - biochemical profile OT - body composition OT - child growth OT - in silico study OT - oral nutrition supplement COIS- SS, SV, MS, MV, SG, KL, and KV were employed by MetFlux Research Private Limited. EDAT- 2025/04/11 06:25 MHDA- 2025/04/11 06:26 PMCR- 2025/01/01 CRDT- 2025/04/11 05:40 PHST- 2024/10/30 00:00 [received] PHST- 2025/03/11 00:00 [accepted] PHST- 2025/04/11 06:26 [medline] PHST- 2025/04/11 06:25 [pubmed] PHST- 2025/04/11 05:40 [entrez] PHST- 2025/01/01 00:00 [pmc-release] AID - 10.3389/fnut.2025.1519756 [doi] PST - epublish SO - Front Nutr. 2025 Mar 27;12:1519756. doi: 10.3389/fnut.2025.1519756. eCollection 2025. PMID- 40211250 OWN - NLM STAT- MEDLINE DCOM- 20250411 LR - 20250413 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Apr 10 TI - Domestic violence and childhood trauma among married women using machine learning approach: a cross-sectional study. PG - 1340 LID - 10.1186/s12889-025-22537-2 [doi] LID - 1340 AB - BACKGROUND: Globally, 27% of ever-partnered women aged 15-49 have experienced physical, sexual, or intimate partner violence at least once in their lifetime. In Saudi Arabia, domestic violence (DV) remains a concern despite cultural and economic advancements. This study aims to measure the prevalence and factors associated with DV as well as childhood trauma (CT) in the Al Hasa region. METHOD: A cross-sectional study was conducted on 503 married women by using convenient sampling reporting DV and CT using two validated questionnaires, respectively. Descriptive statistics were used to analyze the numbers and percentages. Pearson's r correlation was applied to investigate the correlation between risk factors. The multilayer perceptron model has been applied to estimate the most important factors contributing to DV and CT. RESULTS: Out of 503 respondents, most of them had low experience of DV and childhood trauma, while the prevalence of DV was 4.86%, with controlling behavior of the intimate partner (6.09%) and psychological violence most commonly reported. CT was experienced by 18.90% of respondents, primarily emotional neglect (31.44). The median score of DV was 1.99 (0.81), and that of CT was 2.15(0.45). Among the DV subscales, the median score of psychological violence (2.00, IQR = 0.50) and controlling behavior (2.25 with IQR 0.50) was higher compared to physical and sexual violence, whereas the emotional neglect subscale mean score was the highest among the CT subscales, 2.50 (0.50). DV and childhood trauma were significantly associated with BMI ([Formula: see text] < 0.001) and education of women ([Formula: see text]< 0.001) respectively. The result of ML model showed that the influential predictors of DV and CT are physical violence and physical neglect respectively. CONCLUSION: The present study revealed a positive correlation between CT and DV. Women who experienced emotional neglect or abuse during childhood were more likely to report controlling behaviors and psychological violence in their relationships. CT was reported more frequently than DV and women with higher education levels reported greater childhood trauma. Even with low prevalence, such sensitive subjects must not be discredited. Saudi women should embrace education, employment, and awareness of their rights with the rapid societal change, marking a new beginning for women's empowerment and safety. CI - (c) 2025. The Author(s). FAU - Al Mutair, Abbas AU - Al Mutair A AD - Research Center, Almoosa Health Group, Al-Ahsa, Saudi Arabia. AD - Almoosa College of Health Sciences, Al-Ahsa, Saudi Arabia. AD - College of Nursing, Princess Norah Bint Abdulrahman University, Riyadh, Saudi Arabia. AD - Department of Nursing, Prince Sultan Military College of Health Sciences, Dahran, Saudi Arabia. AD - School of Nursing, Wollongong University, Sydney, Australia. FAU - Saha, Chandni AU - Saha C AD - Research Center, Almoosa Health Group, Al-Ahsa, Saudi Arabia. FAU - Alhassan, Layila AU - Alhassan L AD - Patient Experience, Almoosa Specialist Hospital, Al-Ahsa, Saudi Arabia. FAU - Albahrani, Hawra AU - Albahrani H AD - Social Services, Almoosa Specialist Hospital, Al-Ahsa, Saudi Arabia. FAU - Alkhamis, Norah A AU - Alkhamis NA AD - Patient Experience Administration, King Saud Medical City, Riyadh, Saudi Arabia. FAU - Al Sultan, Hajar AU - Al Sultan H AD - English and Language Department, College of Arts, King Faisal University, Hofuf, Al-Ahsa, Saudi Arabia. FAU - Daniyal, Muhammad AU - Daniyal M AD - Research Center, Almoosa Specialist Hospital, Al-Ahsa, Saudi Arabia. muhammad.daniyal@almoosahealth.com.sa. FAU - Elgamri, Alya AU - Elgamri A AD - Faculty of Dentistry, University of Khartoum, Khartoum, Sudan. LA - eng PT - Journal Article DEP - 20250410 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Adult MH - Saudi Arabia/epidemiology MH - Middle Aged MH - Young Adult MH - *Domestic Violence/statistics & numerical data MH - Adolescent MH - Surveys and Questionnaires MH - *Machine Learning MH - Prevalence MH - Risk Factors MH - *Adult Survivors of Child Abuse/statistics & numerical data MH - *Adverse Childhood Experiences/statistics & numerical data PMC - PMC11984275 OTO - NOTNLM OT - Childhood trauma OT - Domestic violence OT - Intimate partner violence OT - Women empowerment OT - Women rights COIS- Declarations. Ethical approval and consent to participate: The present study adhered to the Declaration of Helsinki and informed consent was obtained from each individual participating in the study on an electronic consent form. Ethical approval from the Institutional Review Board (IRB), Almoosa Specialist Hospital was obtained before initiating the data collection (IRB log number: ARC-22.04.07). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/04/11 06:25 MHDA- 2025/04/11 06:26 PMCR- 2025/04/10 CRDT- 2025/04/11 00:18 PHST- 2025/01/19 00:00 [received] PHST- 2025/03/28 00:00 [accepted] PHST- 2025/04/11 06:26 [medline] PHST- 2025/04/11 06:25 [pubmed] PHST- 2025/04/11 00:18 [entrez] PHST- 2025/04/10 00:00 [pmc-release] AID - 10.1186/s12889-025-22537-2 [pii] AID - 22537 [pii] AID - 10.1186/s12889-025-22537-2 [doi] PST - epublish SO - BMC Public Health. 2025 Apr 10;25(1):1340. doi: 10.1186/s12889-025-22537-2. PMID- 40211215 OWN - NLM STAT- MEDLINE DCOM- 20250411 LR - 20250413 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 25 IP - 1 DP - 2025 Apr 10 TI - A nomogram based on peripheral blood count between 12 and 18 weeks of gestation for predicting early-onset pre-eclampsia in pregnant women: a retrospective case-control study. PG - 421 LID - 10.1186/s12884-025-07520-4 [doi] LID - 421 AB - BACKGROUND: Early-onset pre-eclampsia (PE), which delivered before 34 weeks of gestation, is associated with high maternal and pediatric morbidity and mortality. Several studies have examined predictive factors and models to identify individuals at risk for early-onset pre-eclampsia. However, implementing these methods often requires additional tests and increases the financial burden on pregnant women. Our study aimed to determine if early-onset PE development could be predicted using a simple, convenient, and easily accessible test: the peripheral blood count. METHODS: In this study, we conducted a review of pregnant women who received routine prenatal visit and delivered in our hospital from April 2019 to April 2022. For each patient with PE, we matched them 1:1 with healthy pregnant women who were similar in terms of age, parity, and pre-gestational BMI. We gathered routine peripheral blood cell results between 12 and 18 weeks of gestation and utilized multivariate logistic regression to determine independent risk factors. Subsequently, a nomogram was created to forecast the likelihood of early-onset pre-eclampsia. Lastly, we assessed the model's predictive performance. RESULTS: In our study, a total of 254 patients with PE were included, comprising of 41 patients with early-onset PE and 213 patients with late-onset PE, as well as 254 cases of normotensive pregnancy. The nomogram included four risk factors: mean corpuscular hemoglobin concentration (MCHC) >/= 340.50 g/l, neutrophil-to-lymphocyte ratio (NLR) 3 hours/day. BP was measured three times per participant using a validated oscillometric device, following the American Academy of Pediatrics (AAP) guidelines. Hypertension was defined as BP >/= 95th percentile for age, sex, and height. Multivariate logistic regression was employed to assess the association between obesity, screen time, and hypertension, adjusting for physical activity, socioeconomic status (SES), family history of hypertension, and dietary factors. Results A total of 82 participants (23.4%) were hypertensive, with a significantly higher prevalence in obese adolescents (n = 64, 36.6%) compared to non-obese adolescents (n = 18, 10.3%) (p < 0.001). Excessive screen time (>3 hours/day) was an independent predictor of hypertension (adjusted odds ratio (aOR) = 2.58, 95% CI: 1.73-3.86; p < 0.001). Recreational screen time (>3 hours/day) was more strongly associated with hypertension (aOR = 3.12, 95% CI: 2.10-4.02) compared to educational screen time (aOR = 1.75, 95% CI: 1.21-2.44). Adolescents with both obesity and excessive screen time had the highest hypertension prevalence (52.4%), significantly exceeding those with either risk factor alone. The combined risk group had an aOR = 5.14 (95% CI: 3.28-7.56), suggesting a potential interaction effect, though formal mediation analysis was not performed. Low physical activity (Physical Activity Questionnaire for Older Children (PAQ-C) score < 2.33) was also associated with hypertension (aOR = 1.62, 95% CI: 1.04-2.51; p = 0.033). Conclusion Obesity and excessive screen time are independently and jointly associated with early-onset hypertension in adolescents. These findings emphasize the need for targeted interventions, including routine BP screening for high-risk adolescents, school-based digital wellness programs, and structured physical activity initiatives. While this study establishes associations, not causality, further longitudinal research is required to explore the causal pathways and potential interaction effects between obesity, screen time, and hypertension. CI - Copyright (c) 2025, Yasin et al. FAU - Yasin, Sadaf AU - Yasin S AD - Internal Medicine, Shaheed Mohtarma Benazir Bhutto Institute of Trauma, Larkana, PAK. FAU - Hasnain, Muhammad AU - Hasnain M AD - Internal Medicine, Shaheed Mohtarma Benazir Bhutto Institute of Trauma, Larkana, PAK. FAU - Khan, Fahad R AU - Khan FR AD - Cardiology, Lady Reading Hospital, Peshawar, PAK. FAU - Aslam, Kamran AU - Aslam K AD - Cardiology, Lady Reading Hospital, Peshawar, PAK. FAU - Farooq, Nasir AU - Farooq N AD - Cardiology, Lady Reading Hospital, Peshawar, PAK. FAU - Ihsan, Atif AU - Ihsan A AD - Cardiology, Lady Reading Hospital, Peshawar, PAK. LA - eng PT - Journal Article DEP - 20250303 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC11966368 OTO - NOTNLM OT - adolescents OT - blood pressure regulation OT - digital screen time OT - hypertension OT - obesity OT - physical activity OT - public health interventions OT - sedentary lifestyle COIS- Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Review Board (IRB) Committee of Lady Reading Hospital Peshawar and Institutional Ethical Review Board (IERB) of Shaheed Muhtarma Benazir Bhutto Institute of Trauma issued approval 563/IRBLRH/MTI and SMBB/ERC-2022/091. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2025/04/04 06:25 MHDA- 2025/04/04 06:26 PMCR- 2025/03/03 CRDT- 2025/04/04 05:10 PHST- 2025/03/03 00:00 [accepted] PHST- 2025/04/04 06:26 [medline] PHST- 2025/04/04 06:25 [pubmed] PHST- 2025/04/04 05:10 [entrez] PHST- 2025/03/03 00:00 [pmc-release] AID - 10.7759/cureus.79975 [doi] PST - epublish SO - Cureus. 2025 Mar 3;17(3):e79975. doi: 10.7759/cureus.79975. eCollection 2025 Mar. PMID- 40181614 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260902 IS - 1475-2662 (Electronic) IS - 0007-1145 (Print) IS - 0007-1145 (Linking) VI - 133 IP - 7 DP - 2025 Apr 14 TI - Exploratory analyses of frequent high-fat food intake in diets and its association with increased odds of atopic dermatitis in Singapore and Malaysia Young Chinese adults. PG - 977-986 LID - 10.1017/S0007114525000716 [doi] AB - High-fat food intake is associated with atopic dermatitis (AD), but the role of habitual dietary habits related to the frequency of high-fat food intake remains unclear. To address this, we developed a frequency-based dietary index, Diet Quality based on Dietary Fat Score, to assess high-fat food intake and examined its association with AD in 13 561 young Chinese adults (mean age = 22.51 years, (sd 5.90)) from Singapore and Malaysia. Using an investigator-administered questionnaire aligned with the validated International Study of Asthma and Allergies in Childhood protocol, we conducted multivariable logistic regression analysis, adjusting for demographics, body mass index, genetic predisposition and lifestyle factors, with false discovery rate correction for multiple comparisons. Frequent high-fat food intake was associated with higher odds of AD (adjusted OR (AOR): 1.53; 95 % CI: 1.31, 1.77; P< 0.001). The association remained significant regardless of total fat intake (AOR: 1.45; 95 % CI: 1.05, 1.80; P< 0.001) and among individuals with high fruit and vegetable intake (AOR: 1.49; 95 % CI: 1.19, 1.86; P< 0.001) or low energy intake (AOR: 1.40; 95 % CI: 1.05, 1.86; P< 0.05). No synergistic effects were observed between dietary factors. These findings highlight that frequent intake of high-fat foods is independently associated with AD, emphasising the potential of dietary moderation in AD risk management. FAU - Lim, Jun Jie AU - Lim JJ AUID- ORCID: 0000-0001-5485-1749 AD - Department of Biological Sciences, Faculty of Science, National University of Singapore, 117543Singapore. FAU - Reginald, Kavita AU - Reginald K AD - Department of Biological Sciences, Faculty of Science, National University of Singapore, 117543Singapore. AD - Department of Biological Sciences, School of Medicine and Life Sciences, Sunway University, Petaling Jaya47500, Selangor, Malaysia. FAU - Say, Yee-How AU - Say YH AD - Department of Biological Sciences, Faculty of Science, National University of Singapore, 117543Singapore. AD - Department of Biological Sciences, School of Medicine and Life Sciences, Sunway University, Petaling Jaya47500, Selangor, Malaysia. AD - Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman (UTAR), Kampar31900, Perak, Malaysia. FAU - Liu, Mei Hui AU - Liu MH AD - Department of Food Science & Technology, Faculty of Science, National University of Singapore, 117543Singapore. FAU - Chew, Fook Tim AU - Chew FT AD - Department of Biological Sciences, Faculty of Science, National University of Singapore, 117543Singapore. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250404 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 RN - 0 (Dietary Fats) RN - Chinese people SB - IM MH - Adult MH - Female MH - Humans MH - Male MH - Young Adult MH - *Dermatitis, Atopic/etiology/epidemiology MH - *Diet MH - *Dietary Fats/adverse effects/administration & dosage MH - *Feeding Behavior MH - Fruit MH - Logistic Models MH - Malaysia/epidemiology MH - Risk Factors MH - Singapore/epidemiology MH - Surveys and Questionnaires MH - Vegetables MH - East Asian People PMC - PMC12198345 OTO - NOTNLM OT - Atopic dermatitis OT - Dietary fats OT - Dietary habits OT - Epidemiology OT - Intake frequencies EDAT- 2025/04/04 06:26 MHDA- 2026/07/30 12:42 PMCR- 2025/06/26 CRDT- 2025/04/04 02:33 PHST- 2026/07/30 12:42 [medline] PHST- 2025/04/04 06:26 [pubmed] PHST- 2025/04/04 02:33 [entrez] PHST- 2025/06/26 00:00 [pmc-release] AID - S0007114525000716 [pii] AID - 10.1017/S0007114525000716 [doi] PST - ppublish SO - Br J Nutr. 2025 Apr 14;133(7):977-986. doi: 10.1017/S0007114525000716. Epub 2025 Apr 4. PMID- 40180415 OWN - NLM STAT- MEDLINE DCOM- 20250403 LR - 20260127 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 4 DP - 2025 Apr 2 TI - Teens and opioids postsurgery (TOPS): protocol for a prospective observational study describing associations between sleep deficiency and opioid use following outpatient surgery in adolescents. PG - e099679 LID - 10.1136/bmjopen-2025-099679 [doi] LID - e099679 AB - INTRODUCTION: The opioid crisis is a significant burden on adolescent public health in the USA. Medical use of prescription opioids is a pathway via which adolescents transition to opioid misuse, opioid use disorder and overdose. More than half of all opioids prescribed to adolescents are for pain management following surgery. Yet, little is known about the critical period following surgery during which adolescents initiate opioid misuse or the modifiable mechanisms (such as sleep deficiency) contributing to this process. This prospective observational study will broaden our knowledge by examining associations between sleep deficiency and opioid use and misuse following surgery. We will also examine behavioural, psychological, family and social factors linking sleep deficiency with opioid use and misuse. METHODS AND ANALYSIS: Adolescents (10-19 years) undergoing outpatient orthopaedic surgery, along with one parent, will be recruited from two paediatric hospitals, for a sample of 400 dyads. Adolescents will be assessed at six timepoints. Before surgery, participants will undergo comprehensive multimodal sleep assessments (sleep surveys and actigraphy). Participants will also report on previous substance use, pain intensity and psychosocial, family and social factors. Adolescents will then be closely monitored over the first 14 days following surgery using ecological momentary assessment methods to capture real-time, naturalistic, daily data on sleep, opioid use, pain and psychological factors (including mood, affect and subjective response to opioid use). Opioid use (total number of doses and duration) will be measured with an innovative electronic medication monitoring device following surgery. Follow-up assessments at 3 months, 6 months, 12 months and 24 months will track the development of opioid misuse over time. Our primary outcomes include opioid use during the immediate 14 days following surgery and the presence of opioid misuse at 24 months after surgery. Multilevel mediation models will determine associations between predictor variables and acute postsurgical opioid use. We will apply modern machine learning algorithms to develop and validate models predicting adolescent prescription opioid misuse at 24 months from surgery. ETHICS AND DISSEMINATION: This study was approved by Advarra's Center for Institutional Review Board Intelligence (CIRBI) (Protocol 00072049), which serves as the single IRB of record for this multisite study. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Groenewald, Cornelius B AU - Groenewald CB AD - Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA groenewald@stanford.edu. FAU - Palermo, Tonya AU - Palermo T AD - Center for Child Health, Behavior & Development, Seattle Children's Research Institute, Seattle, Washington, USA. AD - Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, Washington, USA. FAU - Rabbitts, Jennifer A AU - Rabbitts JA AD - Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA. FAU - Flack, Rebecca L AU - Flack RL AD - Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA. FAU - Kreider, Sophia L AU - Kreider SL AUID- ORCID: 0009-0004-0575-9769 AD - Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA. LA - eng GR - R01 HL166337/HL/NHLBI NIH HHS/United States PT - Clinical Trial Protocol PT - Journal Article DEP - 20250402 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 RN - 0 (Analgesics, Opioid) SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Young Adult MH - *Ambulatory Surgical Procedures/adverse effects MH - *Analgesics, Opioid/therapeutic use/adverse effects MH - Observational Studies as Topic MH - *Opioid-Related Disorders/epidemiology/etiology MH - *Orthopedic Procedures/adverse effects MH - *Postoperative Pain/drug therapy MH - Prospective Studies MH - *Sleep Wake Disorders PMC - PMC11966959 OTO - NOTNLM OT - Adolescent OT - Clinical Protocols OT - PUBLIC HEALTH OT - SLEEP MEDICINE OT - Substance misuse COIS- Competing interests: None declared. EDAT- 2025/04/04 00:25 MHDA- 2025/04/04 00:26 PMCR- 2025/04/02 CRDT- 2025/04/03 20:33 PHST- 2025/04/04 00:26 [medline] PHST- 2025/04/04 00:25 [pubmed] PHST- 2025/04/03 20:33 [entrez] PHST- 2025/04/02 00:00 [pmc-release] AID - bmjopen-2025-099679 [pii] AID - 10.1136/bmjopen-2025-099679 [doi] PST - epublish SO - BMJ Open. 2025 Apr 2;15(4):e099679. doi: 10.1136/bmjopen-2025-099679. PMID- 40179624 OWN - NLM STAT- MEDLINE DCOM- 20250416 LR - 20260506 IS - 1878-5883 (Electronic) IS - 0022-510X (Linking) VI - 472 DP - 2025 May 15 TI - Differentiating between mild papilledema and pseudopapilledema on fundus photography. PG - 123482 LID - S0022-510X(25)00099-1 [pii] LID - 10.1016/j.jns.2025.123482 [doi] AB - OBJECTIVE: True papilledema can be difficult to distinguish from pseudopapilledema, especially if mild. Tele-ophthalmology allows fundus photos of suspected disc edema to be sent remotely to neuro-ophthalmologists for their expert interpretation. This study evaluated the ability of neuro-ophthalmologists to discriminate papilledema from pseudopapilledema in mild cases of optic disc swelling based on fundus photographs, with and without patient information. METHODS: Fundus photographs from 55 patients referred to two neuro-ophthalmology centers for suspicion of papilledema with mild optic disc swelling were reviewed. Patients with normal visual function and no evidence of secondary intracranial hypertension were included. Strict definitions were used to define papilledema and pseudopapilledema. Three neuro-ophthalmologists rated fundus photos as either papilledema or pseudopapilledema before and after the provision of patient age, sex, body mass index (BMI), and visual acuity. RESULTS: Twenty-nine patients fulfilled criteria for the papilledema group and 26 in the pseudopapilledema group. Fifty-one subjects were female, average age was 32.8 years, and average BMI was 30.9 kg/m(2). When photos were rated in isolation, overall accuracy was 59.4 % and inter-rater reliability was poor (k = 0.052). The true positive rate was 56.3 %, true negative rate 62.8 %, false positive rate 37.2 %, and false negative rate 43.7 %. Providing patient information improved overall accuracy to 64.2 % and inter-rater reliability to k = 0.37. CONCLUSIONS: It is difficult even for neuro-ophthalmologists to correctly distinguish mild papilledema from pseudopapilledema based on fundus photographs alone. Providing basic patient information in telemedicine referrals can improve clinical appraisal and guide the invasiveness of investigations. CI - Copyright (c) 2025. Published by Elsevier B.V. FAU - Tien, Marko Chi-Wei AU - Tien MC AD - University of British Columbia, Faculty of Medicine, Vancouver, British Columbia, Canada. FAU - Xie, Jim AU - Xie J AD - University of Toronto, Faculty of Medicine, Department of Ophthalmology and Vision Sciences, Toronto, Ontario, Canada. FAU - Handzic, Armin AU - Handzic A AD - University of Zurich, Faculty of Medicine, Zurich, Switzerland. FAU - Donaldson, Laura AU - Donaldson L AD - McMaster University, Department of Ophthalmology, Hamilton, Ontario, Canada. FAU - Margolin, Edward AU - Margolin E AD - University of Toronto, Faculty of Medicine, Department of Ophthalmology and Vision Sciences, Toronto, Ontario, Canada; University of Toronto, Faculty of Medicine, Department of Medicine, Division of Neurology, Toronto, Ontario, Canada. Electronic address: Edward.margolin@uhn.ca. LA - eng PT - Journal Article DEP - 20250330 PL - Netherlands TA - J Neurol Sci JT - Journal of the neurological sciences JID - 0375403 RN - Pseudopapilledema SB - IM MH - Humans MH - *Papilledema/diagnosis/diagnostic imaging MH - Female MH - Male MH - Adult MH - *Fundus Oculi MH - *Eye Diseases, Hereditary/diagnosis MH - Diagnosis, Differential MH - *Photography/methods MH - Middle Aged MH - Young Adult MH - *Optic Nerve Diseases/diagnosis MH - Retrospective Studies MH - Adolescent OTO - NOTNLM OT - Fundus photography OT - Idiopathic intracranial hypertension OT - Papilledema OT - Pseudopapilledema OT - Telemedicine COIS- Declaration of competing interest None. EDAT- 2025/04/04 00:25 MHDA- 2025/04/17 00:24 CRDT- 2025/04/03 18:07 PHST- 2025/01/12 00:00 [received] PHST- 2025/02/28 00:00 [revised] PHST- 2025/03/27 00:00 [accepted] PHST- 2025/04/17 00:24 [medline] PHST- 2025/04/04 00:25 [pubmed] PHST- 2025/04/03 18:07 [entrez] AID - S0022-510X(25)00099-1 [pii] AID - 10.1016/j.jns.2025.123482 [doi] PST - ppublish SO - J Neurol Sci. 2025 May 15;472:123482. doi: 10.1016/j.jns.2025.123482. Epub 2025 Mar 30. PMID- 40178601 OWN - NLM STAT- MEDLINE DCOM- 20250920 LR - 20261010 IS - 1432-1912 (Electronic) IS - 0028-1298 (Linking) VI - 398 IP - 9 DP - 2025 Sep TI - Immunocyte phenotypes and childhood disease susceptibility: insights from bidirectional Mendelian randomization and implications for immunomodulatory therapies. PG - 12599-12613 LID - 10.1007/s00210-025-04091-1 [doi] AB - Immune cells are essential for maintaining immune homeostasis during childhood and influence both growth and disease susceptibility. However, the causal relationships between immunocyte phenotypes and childhood diseases remain unclear. This study employed a two-sample Mendelian Randomization (MR) analysis to assess causal associations between 731 immunocyte phenotypes and four major childhood diseases: childhood obesity, childhood absence epilepsy, childhood asthma, and childhood allergies. Genome-wide association study (GWAS) data were used, and stringent instrumental variable (IV) selection and multiple sensitivity analyses, including MR-Egger, weighted median, and leave-one-out tests, were applied to validate the robustness of the results. Significant associations were identified between specific T cell, monocyte, and B cell phenotypes and childhood diseases. Notably, CD8bright T cells and CD19 + B cells were positively correlated with childhood obesity, while monocyte subtypes were strongly associated with asthma pathophysiology. Reverse MR analysis indicated no significant causal effects of childhood diseases on immune phenotypes, except for negative associations between childhood asthma and TCRgd AC, and childhood allergy and CD28 + CD45RA + CD4 + cells. These findings highlight the critical role of immune dysregulation in childhood disease etiology and suggest potential targets for immunomodulatory therapies. Understanding these immune-disease interactions may inform novel pharmacological interventions, particularly in immune-mediated disorders such as asthma and obesity. Further research into immune-targeted therapies could enhance treatment strategies for pediatric conditions associated with chronic inflammation and immune dysfunction. CI - (c) 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Hong, Yanggang AU - Hong Y AD - The Second School of Medicine, Wenzhou Medical University, Wenzhou, 325035, Zhejiang Province, China. sun160414@icloud.com. FAU - Wang, Yi AU - Wang Y AD - The First School of Medicine, Wenzhou Medical University, Wenzhou, 325035, Zhejiang Province, China. FAU - Shu, Wanyi AU - Shu W AD - School of Ophthalmology & Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, 325035, Zhejiang Province, China. LA - eng PT - Journal Article DEP - 20250403 PL - Germany TA - Naunyn Schmiedebergs Arch Pharmacol JT - Naunyn-Schmiedeberg's archives of pharmacology JID - 0326264 SB - IM MH - Humans MH - Mendelian Randomization Analysis MH - Phenotype MH - Child MH - Genome-Wide Association Study MH - *Asthma/immunology/genetics MH - *Hypersensitivity/immunology/genetics MH - *Pediatric Obesity/immunology/genetics MH - Genetic Predisposition to Disease MH - Disease Susceptibility OTO - NOTNLM OT - Childhood disease OT - Immune modulation OT - Immunology OT - Immunotherapy OT - Mendelian randomization OT - Pharmacology COIS- Declarations. Ethical approval and informed consent: Ethical approval was not applicable because this study used data from publicly available databases. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/04/03 12:23 MHDA- 2025/09/20 06:31 CRDT- 2025/04/03 11:14 PHST- 2025/02/07 00:00 [received] PHST- 2025/03/21 00:00 [accepted] PHST- 2025/09/20 06:31 [medline] PHST- 2025/04/03 12:23 [pubmed] PHST- 2025/04/03 11:14 [entrez] AID - 10.1007/s00210-025-04091-1 [pii] AID - 10.1007/s00210-025-04091-1 [doi] PST - ppublish SO - Naunyn Schmiedebergs Arch Pharmacol. 2025 Sep;398(9):12599-12613. doi: 10.1007/s00210-025-04091-1. Epub 2025 Apr 3. PMID- 40177206 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250404 IS - 1948-5182 (Print) IS - 1948-5182 (Electronic) VI - 17 IP - 3 DP - 2025 Mar 27 TI - Hepatic cirrhosis and decompensation: Key indicators for predicting mortality risk. PG - 104580 LID - 10.4254/wjh.v17.i3.104580 [doi] LID - 104580 AB - Liver cirrhosis represents the final stage of liver diseases. The transition from the compensated to the decompensated form is a critical phase, as it is associated with a negative impact on patient prognosis. Therefore, having a tool to identify patients at higher risk of complications and mortality is an ideal goal. Currently, the validated scores for this purpose are the model for end-stage liver disease score and the Child-Pugh score. However, these scores have limitations, as they do not account for other factors associated with liver cirrhosis that are equally relevant from a prognostic perspective. Among these, alterations in body composition, particularly sarcopenia, increase the risk of mortality and should therefore be considered in the comprehensive assessment of patients with liver cirrhosis. CI - (c)The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. FAU - Del Cioppo, Sara AU - Del Cioppo S AD - Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome 00185, Italy. FAU - Faccioli, Jessica AU - Faccioli J AD - Department of Translational and Precision Medicine, Sapienza University of Rome, Rome 00185, Italy. FAU - Ridola, Lorenzo AU - Ridola L AD - Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome 00185, Italy. lorenzo.ridola@uniroma1.it. LA - eng PT - Journal Article PT - Review PL - United States TA - World J Hepatol JT - World journal of hepatology JID - 101532469 PMC - PMC11959669 OTO - NOTNLM OT - Artificial intelligence OT - Child-Pugh OT - Decompensation OT - Liver cirrhosis OT - Model for end-stage liver disease OT - Mortality OT - Obesity OT - Prognostic score OT - Sarcopenia OT - Survival COIS- Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript. EDAT- 2025/04/03 09:06 MHDA- 2025/04/03 09:07 PMCR- 2025/03/27 CRDT- 2025/04/03 04:39 PHST- 2024/12/25 00:00 [received] PHST- 2025/02/28 00:00 [revised] PHST- 2025/03/10 00:00 [accepted] PHST- 2025/04/03 09:07 [medline] PHST- 2025/04/03 09:06 [pubmed] PHST- 2025/04/03 04:39 [entrez] PHST- 2025/03/27 00:00 [pmc-release] AID - 10.4254/wjh.v17.i3.104580 [doi] PST - ppublish SO - World J Hepatol. 2025 Mar 27;17(3):104580. doi: 10.4254/wjh.v17.i3.104580. PMID- 40177080 OWN - NLM STAT- MEDLINE DCOM- 20250515 LR - 20250515 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - A predictive model to explore risk factors for Henoch-Schonlein purpura nephritis in children: a retrospective cross-sectional study. PG - 1507408 LID - 10.3389/fpubh.2025.1507408 [doi] LID - 1507408 AB - OBJECTIVE: The risk factors for Henoch-Schonlein purpura nephritis (HSPN) remain largely unclear, particularly in family environment and vaccination. This study aimed to develop a predictive framework to quantify the risk of HSPN by examining family environmental factors and COVID-19 vaccination outcomes in children with Henoch-Schonlein purpura (HSP) in Anhui, China. METHODS: This study retrospectively analyzed 362 children diagnosed with HSP at Anhui Children's Hospital between January 2020 and February 2024. A questionnaire was designed to collect information from enrolled children. For patients with incomplete medical records, parents were contacted via phone or the questionnaire was sent to them to complete the survey. After data collection, the patients were split randomly into a training group and a validation group at a 7:3 ratio, univariate and multivariate logistic regression analyses were performed to identify risk factors for nephritis, and a nomogram was constructed from these factors to provide a visual prediction of the likelihood of nephritis in HSP. The nomogram's performance was evaluated in both the training and validation groups using the area under the receiver operating characteristic (AUC) curve, calibration plots, and decision curve analysis (DCA). RESULTS: The study identified family income/month, age of onset, BMI, number of recurrences, and COVID-19 vaccination status as independent risk factors for HSPN. A nomogram was subsequently developed afterward using these factors. In the training group, the nomogram achieved an area under the curve (AUC) of 0.83 (95% CI: 0.78-0.88), while in the validation group, the AUC was 0.90 (95% CI: 0.84-0.96), demonstrating strong predictive performance. The calibration curve showed that the nomogram's predictions were well-aligned with the actual outcomes. Additionally, DCA indicated that the nomogram provided considerable clinical net benefit. CONCLUSION: The nomogram offers accurate risk prediction for nephritis in children with HSP, helping healthcare professionals identify high-risk patients early and make informed clinical decisions. CI - Copyright (c) 2025 Yang, Zhang, Dong and Deng. FAU - Yang, Qianwen AU - Yang Q AD - Department of Nephrology, Children's Hospital of Anhui Medical University, Children's Medical Center of Anhui Medical University, Hefei, Anhui, China. AD - Department of Pediatrics, Hefei Maternal and Child Health Hospital, Hefei, Anhui, China. FAU - Zhang, Maoyang AU - Zhang M AD - Department of Nephrology, Children's Hospital of Anhui Medical University, Children's Medical Center of Anhui Medical University, Hefei, Anhui, China. FAU - Dong, Zilong AU - Dong Z AD - Department of Nephrology, Children's Hospital of Anhui Medical University, Children's Medical Center of Anhui Medical University, Hefei, Anhui, China. FAU - Deng, Fang AU - Deng F AD - Department of Nephrology, Children's Hospital of Anhui Medical University, Children's Medical Center of Anhui Medical University, Hefei, Anhui, China. LA - eng PT - Journal Article DEP - 20250319 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *IgA Vasculitis/epidemiology/complications MH - Retrospective Studies MH - Male MH - Female MH - Risk Factors MH - Child MH - China/epidemiology MH - Cross-Sectional Studies MH - Child, Preschool MH - COVID-19/prevention & control/epidemiology MH - *Nephritis/etiology/epidemiology MH - Nomograms MH - Adolescent MH - Surveys and Questionnaires MH - Infant PMC - PMC11961411 OTO - NOTNLM OT - Henoch-Schonlein purpura OT - children OT - nephritis OT - nomogram OT - predictive models COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/04/03 09:06 MHDA- 2025/04/03 18:25 PMCR- 2025/03/19 CRDT- 2025/04/03 04:38 PHST- 2024/10/07 00:00 [received] PHST- 2025/02/28 00:00 [accepted] PHST- 2025/04/03 18:25 [medline] PHST- 2025/04/03 09:06 [pubmed] PHST- 2025/04/03 04:38 [entrez] PHST- 2025/03/19 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1507408 [doi] PST - epublish SO - Front Public Health. 2025 Mar 19;13:1507408. doi: 10.3389/fpubh.2025.1507408. eCollection 2025. PMID- 40176563 OWN - NLM STAT- MEDLINE DCOM- 20250516 LR - 20250516 IS - 0035-7715 (Print) IS - 0035-7715 (Linking) VI - 75 IP - 4 DP - 2024 Dec 16 TI - Do children and adolescents with excess body weight and dyslipidemia consume enough vegetables and fruits before participating in the nutritional intervention program? PG - 333-339 LID - 197421 [pii] LID - 10.32394/rpzh/197421 [doi] AB - BACKGROUND: The recommended intake of vegetables and fruits is an important element of dietotherapy in the treatment of excess body weight and dyslipidemia in children and adolescents. OBJECTIVE: Assessment of vegetables and fruits consumption by children and adolescents with excess body weight and diagnosed dyslipidemia before participating in the nutritional intervention program. MATERIAL AND METHODS: The study included 64 children and adolescents (44 boys and 20 girls) aged 8-16 with overweight or obesity and dyslipidemia. These were patients of the Children's Memorial Health Institute in Warsaw referred by a pediatrician to participate in the nutritional intervention program. Vegetables and fruits consumption was estimated based on a 3-day current food record and the validated Food Frequency Questionnaire (FFQ-6). RESULTS: The average consumption of total vegetables and fruits was 593+/-311 g, including 286+/-163 g of vegetables and 306+/-199 g of fruits (no differences in the groups with overweight and obesity, p>0.05). Compared to participants with overweight, patients with obesity consumed more vegetables per 1000 kcal of diet (p=0.034). In total, 41% of children and adolescents had a greater share of vegetables than fruits in meeting the recommendations (no differences between groups of participants with overweight or obesity, p>0.05). About half of the participants ate vegetables and fruits less than once a day. Raw vegetables and fruits were chosen more often than processed ones or juices. CONCLUSIONS: Only 16% of children and adolescents with excess body weight and dyslipidemia before participating in the nutritional intervention program did not consume the recommended amounts of vegetables and fruits set at a minimum of 400 g. In nutritional education, special attention should be paid to promoting the consumption of several portions of vegetables and fruits every day, as well as their appropriate proportions. FAU - Bondyra-Wisniewska, Beata AU - Bondyra-Wisniewska B AD - Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS), Poland. FAU - Harton, Anna AU - Harton A AD - Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS), Poland. LA - eng PT - Journal Article DEP - 20241216 PL - Poland TA - Rocz Panstw Zakl Hig JT - Roczniki Panstwowego Zakladu Higieny JID - 0414756 SB - IM MH - Humans MH - Adolescent MH - Child MH - Female MH - Male MH - *Fruit MH - *Vegetables MH - *Dyslipidemias/diet therapy/prevention & control MH - Poland MH - *Feeding Behavior MH - *Pediatric Obesity/diet therapy MH - *Overweight/diet therapy OTO - NOTNLM OT - adolescents OT - childhood obesity OT - diet OT - dyslipidemia OT - fruits OT - vegetables EDAT- 2025/04/03 09:06 MHDA- 2025/04/03 18:25 CRDT- 2025/04/03 03:23 PHST- 2025/04/03 18:25 [medline] PHST- 2025/04/03 09:06 [pubmed] PHST- 2025/04/03 03:23 [entrez] AID - 197421 [pii] AID - 10.32394/rpzh/197421 [doi] PST - ppublish SO - Rocz Panstw Zakl Hig. 2024 Dec 16;75(4):333-339. doi: 10.32394/rpzh/197421. Epub 2024 Dec 16. PMID- 40176183 OWN - NLM STAT- MEDLINE DCOM- 20250515 LR - 20260329 IS - 2072-1315 (Electronic) IS - 1606-0997 (Print) IS - 1606-0997 (Linking) VI - 44 IP - 1 DP - 2025 Apr 2 TI - The association between fruit and vegetable intake and the odds of asthma among children and adolescents. PG - 99 LID - 10.1186/s41043-025-00820-7 [doi] LID - 99 AB - BACKGROUND: Previous epidemiological studies on the correlation between fruit and vegetable consumption and asthma, the majority of them were conducted in developed countries, have led to conflicting results. This study aimed to examine the relationship between fruit and vegetable intake and the risk of asthma among a large sample of children and adolescents. METHODS: This cross-sectional study was conducted as part of the Global Asthma Network (GAN) on 7667 Iranian children and adolescents. Asthma and its related outcomes were measured using validated questionnaires. A food frequency method was used to assess the dietary intake. The association between fruit and vegetable intake and asthma and its related symptoms was examined using logistic regression. RESULTS: After adjustment for all possible confounding variables, no significant association was found between fruit and vegetable intake and the odds of medication use for asthma and asthma confirmed by a doctor. However, an inverse significant trend was found between fruits intake and current asthma. After adjusting for age, sex, BMI, and the use of television and computers, participants who regularly consumed fruit had a 37% lower likelihood of experiencing wheezing in the past 12 months (OR = 0.63; 95% CI: 0.42-0.94, P trend = 0.001) compared to those who never or only occasionally consumed fruit. Additionally, individuals who reported consuming vegetables most or all days had a 38% reduced chance of wheezing in the past 12 months (OR = 0.62; 95% CI: 0.48-0.80, P trend < 0.001) compared to participants with infrequent vegetable intake. Participants with regular fruit and vegetable intake combined (OR = 0.50; 95% CI: 0.31-0.82, P trend < 0.001) had a 50% lower likelihood of wheezing in the past 12 months in comparison with those who never or only occasionally fruits and vegetables combined consumers. CONCLUSION: Our findings suggest that regular consumption of fruits and vegetables on most or all days has a protective effect against wheezing in the past 12 months. Future longitudinal studies should be conducted to confirm our findings. CI - (c) 2025. The Author(s). FAU - Rostampour, Kimia AU - Rostampour K AD - Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. FAU - Sasanfar, Bahareh AU - Sasanfar B AD - Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran. FAU - Reshadfar, Amirahmad AU - Reshadfar A AD - Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. FAU - Emarati, Alireza AU - Emarati A AD - Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. FAU - Nafei, Zahra AU - Nafei Z AD - Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. nafeiy@yahoo.com. AD - Shahid Sadoughi Hospital, Ebne Sina Boulevard, Yazd, Iran. nafeiy@yahoo.com. FAU - Behniafard, Nasrin AU - Behniafard N AD - Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Department of Allergy and Clinical Immunology, Shahid Sadouhi Hospital, School of Medcine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. FAU - Hashemi-Bajgani, Seyed-Mehdi AU - Hashemi-Bajgani SM AD - Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Department of Internal Medicine, School of Medicine, Afzalipour hospital, Kerman University of Medical Science, Kerman, Iran. FAU - Salehi-Abargouei, Amin AU - Salehi-Abargouei A AD - Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Yazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. LA - eng PT - Journal Article DEP - 20250402 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 SB - IM MH - Humans MH - *Vegetables MH - *Asthma/epidemiology/prevention & control MH - *Fruit MH - Female MH - Male MH - Cross-Sectional Studies MH - Adolescent MH - Child MH - Iran/epidemiology MH - *Diet/statistics & numerical data MH - Respiratory Sounds MH - Risk Factors MH - Surveys and Questionnaires MH - Feeding Behavior MH - Logistic Models PMC - PMC11966831 OTO - NOTNLM OT - Adolescents OT - Asthma OT - Children OT - Fruits OT - Vegetables COIS- Declarations. Competing interests: The authors declare no competing interests. Financial support: This study was financially supported by Shahid Sadoughi University of Medical Science. EDAT- 2025/04/03 00:25 MHDA- 2025/04/03 18:25 PMCR- 2025/04/02 CRDT- 2025/04/02 23:57 PHST- 2024/10/30 00:00 [received] PHST- 2025/03/09 00:00 [accepted] PHST- 2025/04/03 18:25 [medline] PHST- 2025/04/03 00:25 [pubmed] PHST- 2025/04/02 23:57 [entrez] PHST- 2025/04/02 00:00 [pmc-release] AID - 10.1186/s41043-025-00820-7 [pii] AID - 820 [pii] AID - 10.1186/s41043-025-00820-7 [doi] PST - epublish SO - J Health Popul Nutr. 2025 Apr 2;44(1):99. doi: 10.1186/s41043-025-00820-7. PMID- 40175955 OWN - NLM STAT- MEDLINE DCOM- 20250515 LR - 20250515 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 25 IP - 1 DP - 2025 Apr 2 TI - Maternal dietary patterns as predictors of neonatal body composition in Ethiopia: the IABC birth cohort study. PG - 386 LID - 10.1186/s12884-025-07256-1 [doi] LID - 386 AB - BACKGROUND: Malnutrition during pregnancy is associated with adverse birth outcomes, but the importance of maternal diet during pregnancy for neonatal body composition remains inconclusive. This study investigated the role of maternal diet during pregnancy for neonatal body composition in the Ethiopian iABC birth cohort. METHODS: The data stemmed from the first visit at birth comprising 644 mother-child pairs. Shortly after delivery, the diet of the last week of pregnancy was assessed by a non-quantitative and non-validated 18-items food frequency questionnaire. Multiple imputation was used to handle missing data. Twin births and implausible values were excluded from analysis (n = 92). The Dietary Diversity Score (0-9 points) was constructed and exploratory dietary patterns were derived via principal component analysis. Neonatal fat mass and fat-free mass were assessed by air-displacement plethysmography. The associations of maternal Dietary Diversity Score and exploratory dietary patterns with gestational age, neonatal anthropometric measures and body composition were investigated using multiple-adjusted linear regression analysis. RESULTS: In this cohort (n = 552), mean +/- standard deviation (SD) mother's age was 24.1 +/- 4.6 years and the median maternal Dietary Diversity Score was 6 (interquartile range = 5-7). An 'Animal-source food pattern' and a 'Vegetarian food pattern' were identified. The mean +/- SD birth weight was 3096 +/- 363 g and gestational age was 39.0 +/- 1.0 weeks. Maternal adherence to the Animal-source food pattern, but not Vegetarian food pattern, was related to birth weight [79.5 g (95% confidence interval (CI): -14.6, 173.6)]. In the adjusted model, adherence to the Animal-source food pattern was associated with higher neonatal fat-free mass [53.1 g (95% CI: -20.3, 126.6)], while neonates of women with high compared to low adherence to Dietary Diversity Score and Vegetarian food pattern had higher fat mass [19.4 g (95% CI: -7.4, 46.2) and 33.5 g (95% CI: 2.8, 64.1), respectively]. CONCLUSIONS: In this Ethiopian population, maternal diet during pregnancy was associated with neonatal body composition. The analysis of body composition adds important detail to the evaluation of maternal dietary habits for the newborn constitution. CI - (c) 2025. The Author(s). FAU - Nickel, Daniela Viktoria AU - Nickel DV AUID- ORCID: 0000-0002-7490-0779 AD - Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam- Rehbruecke, Nuthetal, Germany. Daniela.Nickel@dife.de. AD - Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany. Daniela.Nickel@dife.de. AD - NutriAct - Competence Cluster Nutrition Research Berlin-Potsdam, Nuthetal, Germany. Daniela.Nickel@dife.de. FAU - Wibaek, Rasmus AU - Wibaek R AD - Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark. AD - Clinical Epidemiology, Steno Diabetes Center Copenhagen, Gentofte, Denmark. FAU - Friis, Henrik AU - Friis H AD - Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark. FAU - Wells, Jonathan C K AU - Wells JCK AD - Population Policy and Practice Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK. FAU - Girma, Tsinuel AU - Girma T AD - Department of Pediatrics and Child Health, Jimma University, Jimma, Ethiopia. AD - Jimma University Clinical and Nutrition Research Partnership (JUCAN), Jimma University, Jimma, Ethiopia. FAU - Kaestel, Pernille AU - Kaestel P AD - Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark. FAU - Michaelsen, Kim F AU - Michaelsen KF AD - Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark. FAU - Admassu, Bitiya AU - Admassu B AD - Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark. AD - Jimma University Clinical and Nutrition Research Partnership (JUCAN), Jimma University, Jimma, Ethiopia. AD - Department of Population and Family Health, Jimma University, Jimma, Ethiopia. FAU - Abera, Mubarek AU - Abera M AD - Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark. AD - Jimma University Clinical and Nutrition Research Partnership (JUCAN), Jimma University, Jimma, Ethiopia. AD - Department of Psychiatry, Jimma University, Jimma, Ethiopia. FAU - Schulze, Matthias B AU - Schulze MB AD - Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam- Rehbruecke, Nuthetal, Germany. AD - Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany. AD - NutriAct - Competence Cluster Nutrition Research Berlin-Potsdam, Nuthetal, Germany. FAU - Danquah, Ina AU - Danquah I AD - Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam- Rehbruecke, Nuthetal, Germany. AD - Heidelberg Institute of Global Health, Universitaetsklinikum Heidelberg, Heidelberg, Germany. FAU - Andersen, Gregers S AU - Andersen GS AD - Clinical Epidemiology, Steno Diabetes Center Copenhagen, Gentofte, Denmark. LA - eng PT - Journal Article DEP - 20250402 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Ethiopia MH - Pregnancy MH - *Body Composition MH - Infant, Newborn MH - Adult MH - *Diet MH - Young Adult MH - *Maternal Nutritional Physiological Phenomena MH - Gestational Age MH - Birth Cohort MH - Cohort Studies MH - Male MH - *Feeding Behavior MH - Birth Weight PMC - PMC11967154 OTO - NOTNLM OT - Body composition OT - Dietary diversity OT - Dietary patterns OT - Ethiopia OT - Neonate OT - Pregnancy OT - iABC COIS- Declarations. Ethics approval and consent to participate: The study was conducted based on the guidelines developed by the Declaration of Helsinki, and ethical approval was obtained from the Jimma University Ethical Review Committee (reference number 23/12/2008). Every mother gave written informed consent on behalf of herself and her newborn. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/04/03 00:25 MHDA- 2025/04/03 18:25 PMCR- 2025/04/02 CRDT- 2025/04/02 23:47 PHST- 2023/02/15 00:00 [received] PHST- 2025/01/29 00:00 [accepted] PHST- 2025/04/03 18:25 [medline] PHST- 2025/04/03 00:25 [pubmed] PHST- 2025/04/02 23:47 [entrez] PHST- 2025/04/02 00:00 [pmc-release] AID - 10.1186/s12884-025-07256-1 [pii] AID - 7256 [pii] AID - 10.1186/s12884-025-07256-1 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2025 Apr 2;25(1):386. doi: 10.1186/s12884-025-07256-1. PMID- 40174888 OWN - NLM STAT- MEDLINE DCOM- 20251001 LR - 20251001 IS - 1543-5474 (Electronic) IS - 1543-3080 (Linking) VI - 22 IP - 10 DP - 2025 Oct 1 TI - Accelerometer Monitoring Duration for Reliable Estimates of Physical Activity, Sedentary Behavior, and Step Counts in Preschoolers. PG - 1307-1314 LID - 10.1123/jpah.2024-0640 [doi] AB - PURPOSE: This study aims to establish the reliability of accelerometer-based measurements for physical activity, sedentary behavior, and step counts in preschoolers and determine the optimal monitoring duration necessary for reliable data. METHODS: The study analyzed data from 434 preschoolers (ages 3-5) who wore waist-worn ActiGraph wGT3X-BT accelerometers for 7 days as part of the Sunrise Study in Spain. Two-way mixed effects intraclass correlation coefficients were calculated for various combinations of daily wear time and number of valid days to assess reliability. The Spearman-Brown prophecy formula was applied to determine the required days to achieve reliability scores of 0.7, 0.8, and 0.9. RESULTS: The findings showed that reliability improved with increased wear time, although intraclass correlation coefficients values were weaker around 7 to 9 hours per day. To achieve a reliability score of 0.7, moderate to vigorous physical activity required 3 to 4 days, light physical activity required 4 to 7 days, and sedentary behavior required 8 to 13 days. Steps per day required 7 to 9 days for a reliability score of 0.7, while other step outcomes needed 10 to 13 days. CONCLUSION: The study provides evidence-based recommendations on the monitoring duration required for reliable estimates of physical activity, sedentary behavior, step counts, and sleep duration in preschoolers using accelerometers. These findings are crucial for researchers and practitioners aiming to accurately assess and promote physical activity in early childhood. FAU - Ramos-Munell, Javier AU - Ramos-Munell J AUID- ORCID: 0000-0002-2628-1184 AD - Epidemiology of Physical Activity and Fitness Across the Lifespan (EPAFit) Research Group, Faculty of Education, Department of Physical Education and Sports, University of Seville, Seville, Spain. FAU - Antczak, Devan AU - Antczak D AUID- ORCID: 0000-0002-2247-1052 AD - Institute for Positive Psychology and Education, Australian Catholic University, North Sydney, NSW, Australia. FAU - Alvarez-Barbosa, Francisco AU - Alvarez-Barbosa F AUID- ORCID: 0000-0001-9107-0618 AD - Epidemiology of Physical Activity and Fitness Across the Lifespan (EPAFit) Research Group, Faculty of Education, Department of Physical Education and Sports, University of Seville, Seville, Spain. FAU - Alfonso-Rosa, Rosa M AU - Alfonso-Rosa RM AUID- ORCID: 0000-0002-4447-0659 AD - Epidemiology of Physical Activity and Fitness Across the Lifespan (EPAFit) Research Group, Faculty of Education, Department of Human Motricity and Sport Performance, University of Seville, Seville, Spain. AD - School of Health and Society within the Faculty of the Arts, Social Sciences and Humanities, University of Wollongong, Wollongong, NSW, Australia. FAU - Del Pozo Cruz, Borja AU - Del Pozo Cruz B AUID- ORCID: 0000-0002-9728-1317 AD - Epidemiology of Physical Activity and Fitness Across the Lifespan (EPAFit) Research Group, Department of Sport Sciences, Faculty of Medicine, Health, and Sports, Universidad Europea de Madrid, Villaviciosa de Od?n, Madrid, Spain. FAU - Del Pozo-Cruz, Jesus AU - Del Pozo-Cruz J AUID- ORCID: 0000-0002-8553-5818 AD - Epidemiology of Physical Activity and Fitness Across the Lifespan (EPAFit) Research Group, Faculty of Education, Department of Physical Education and Sports, University of Seville, Seville, Spain. AD - School of Health and Society within the Faculty of the Arts, Social Sciences and Humanities, University of Wollongong, Wollongong, NSW, Australia. LA - eng PT - Journal Article DEP - 20250401 PL - United States TA - J Phys Act Health JT - Journal of physical activity & health JID - 101189457 SB - IM MH - Humans MH - *Sedentary Behavior MH - Child, Preschool MH - *Exercise/physiology MH - Female MH - Male MH - *Accelerometry/instrumentation/methods MH - Reproducibility of Results MH - Time Factors MH - Spain OTO - NOTNLM OT - 24-hour movement behavior OT - Actigraph OT - early childhood OT - reliability EDAT- 2025/04/03 00:25 MHDA- 2025/10/01 18:28 CRDT- 2025/04/02 19:42 PHST- 2024/09/17 00:00 [received] PHST- 2025/01/23 00:00 [revised] PHST- 2025/02/11 00:00 [accepted] PHST- 2025/10/01 18:28 [medline] PHST- 2025/04/03 00:25 [pubmed] PHST- 2025/04/02 19:42 [entrez] AID - 10.1123/jpah.2024-0640 [doi] PST - epublish SO - J Phys Act Health. 2025 Apr 1;22(10):1307-1314. doi: 10.1123/jpah.2024-0640. Print 2025 Oct 1. PMID- 40174408 OWN - NLM STAT- MEDLINE DCOM- 20250505 LR - 20260827 IS - 1872-7123 (Electronic) IS - 0165-1781 (Print) IS - 0165-1781 (Linking) VI - 348 DP - 2025 Jun TI - Suicidal ideation and avoidant/restrictive food intake disorder: Findings from the ARFID-GEN study. PG - 116471 LID - S0165-1781(25)00119-2 [pii] LID - 10.1016/j.psychres.2025.116471 [doi] AB - This study examined the prevalence of suicidal ideation (SI) among adults with avoidant/restrictive food intake disorder (ARFID) across different demographic groups and explored associations between SI and specific ARFID dimensions. The sample included 3299 adults who screened positive for ARFID using two validated scales. SI over the past two weeks was assessed using item 9 from the Patient Health Questionnaire-9. The overall prevalence of SI was 22.9 %, with a higher prevalence among transgender and gender-diverse (TGD) individuals (34.7 %) compared to cisgender men (17.8 %) and cisgender women (16.8 %). Participants with SI (mean = 27.6 years, SD = 10.1) were younger than those without SI (mean = 32.3 years, SD = 13.4). The ARFID dimensions picky eating/sensory-based avoidance and low appetite/lack of interest in eating or food were positively associated with SI; however, these associations became non-significant after adjusting for age, gender, and depression. Interestingly, fear/concern about aversive consequences was significantly negatively associated with SI after adjusting for covariates. Our results suggest that the fear presentation of ARFID may be a distinct subtype with a lower risk of suicidality compared to other presentations, highlighting the importance of comprehensively evaluating ARFID dimensions and underlying depressive symptoms to better address the risk of suicidality. CI - Copyright (c) 2025. Published by Elsevier B.V. FAU - Qi, Baiyu AU - Qi B AD - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27516, USA. FAU - Kalantzis, Maria A AU - Kalantzis MA AD - Department of Psychology, Bowling Green State University, Bowling Green, OH, 43403, USA. FAU - Thornton, Laura M AU - Thornton LM AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. FAU - White, Jennifer P AU - White JP AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. FAU - MacDermod, Casey M AU - MacDermod CM AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. FAU - Ortiz, Shelby N AU - Ortiz SN AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. FAU - Pisetsky, Emily M AU - Pisetsky EM AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. FAU - Dinkler, Lisa AU - Dinkler L AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, 171 77, Stockholm, Sweden. FAU - Guintivano, Jerry D AU - Guintivano JD AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. FAU - Johnson, Jessica S AU - Johnson JS AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. FAU - Micali, Nadia AU - Micali N AD - Center for Eating and Feeding Disorders Research, Psychiatric Center Ballerup, Mental Health Services of the Capital Region of Denmark, Ballerup, Denmark; Institute of Biological Psychiatry, Psykiatrisk Center Sct. Hans, Boserupvej 2, 4000, Roskilde, Denmark; Great Ormond Street Hospital Institute of Child Health, University College London, London, UK. FAU - Bulik, Cynthia M AU - Bulik CM AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, 171 77, Stockholm, Sweden; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Electronic address: cynthia_bulik@med.unc.edu. LA - eng GR - R56 MH129437/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20250326 PL - Ireland TA - Psychiatry Res JT - Psychiatry research JID - 7911385 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - *Suicidal Ideation MH - Young Adult MH - Middle Aged MH - *Avoidant Restrictive Food Intake Disorder/epidemiology/psychology MH - Prevalence MH - *Feeding and Eating Disorders/epidemiology/psychology MH - Transgender Persons/statistics & numerical data MH - Adolescent PMC - PMC12671335 MID - NIHMS2123900 OTO - NOTNLM OT - Eating disorders OT - Picky eating OT - Selective eating OT - Suicidality OT - Suicide COIS- Declaration of competing interest Dr. Bulik receives royalties from Pearson Education Inc. Dr. Dinkler has received speaker fees from Baxter Medical AB and Fresenius Kabi AB. Other authors declare no competing interests. EDAT- 2025/04/03 00:25 MHDA- 2025/05/05 06:27 PMCR- 2025/12/02 CRDT- 2025/04/02 18:06 PHST- 2024/12/02 00:00 [received] PHST- 2025/03/24 00:00 [revised] PHST- 2025/03/25 00:00 [accepted] PHST- 2025/05/05 06:27 [medline] PHST- 2025/04/03 00:25 [pubmed] PHST- 2025/04/02 18:06 [entrez] PHST- 2025/12/02 00:00 [pmc-release] AID - S0165-1781(25)00119-2 [pii] AID - 10.1016/j.psychres.2025.116471 [doi] PST - ppublish SO - Psychiatry Res. 2025 Jun;348:116471. doi: 10.1016/j.psychres.2025.116471. Epub 2025 Mar 26. PMID- 40170300 OWN - NLM STAT- MEDLINE DCOM- 20250915 LR - 20260812 IS - 1365-2869 (Electronic) IS - 0962-1105 (Linking) VI - 34 IP - 5 DP - 2025 Oct TI - Performance Evaluation of the Verily Numetric Watch Sleep Suite for Digital Sleep Assessment Against In-Lab Polysomnography. PG - e70036 LID - 10.1111/jsr.70036 [doi] AB - The goal was to evaluate the performance of a suite of 12 sleep measures generated by a multi-sensor wrist-worn wearable device, the verily numetric watch (VNW), in a diverse cohort. We used polysomnography (PSG) as reference during one-night simultaneous recording in a sample of N = 41 (18 male, age range: 18-78 years). We performed epoch-by-epoch comparisons for all measures. Key specific analyses were: core accuracy metrics for sleep versus wake classification; bias for continuous measures (Bland-Altman); unweighted Cohen's kappa and accuracy for sleep stage classifications and mean count difference and linearly weighted Cohen's kappa for count metric. In addition, we performed exploratory subgroup analyses by sex, age, skin tone, body mass index and arm hair density. Sensitivity and specificity (95% CI) of sleep versus wake classification were 0.97 (0.96, 0.98) and 0.66 (0.61, 0.71), respectively. Mean total sleep time bias was 14.55 min (1.61, 27.16); wake after sleep onset, -11.77 min (-23.89, 1.09); sleep efficiency, 3.15% (0.68, 5.57); sleep onset latency, -3.24 min (-9.38, 3.57); light-sleep duration, 3.78 min (-7.04, 15.06); deep-sleep duration, 3.91 min (-4.59, 12.60) and rapid eye movement-sleep duration, 6.94 min (0.57, 13.04). Mean difference for the number of awakenings, 0.17: (95% CI: -0.32, 0.71) and overall accuracy of sleep stage classification, 0.78 (0.51, 0.88). Most measures showed statistically significant proportional biases and/or heteroscedasticity. Exploratory subgroup results appeared largely consistent with the overall group, although small samples precluded strong conclusions. These results support the use of VNWs in classifying sleep versus wake, sleep stages and overnight sleep measures. CI - (c) 2025 European Sleep Research Society. FAU - Nelson, Benjamin W AU - Nelson BW AUID- ORCID: 0000-0002-5474-7674 AD - Verily Life Sciences, South San Francisco, California, USA. AD - Department of Psychiatry, Division of Digital Psychiatry, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. FAU - Saeb, Sohrab AU - Saeb S AUID- ORCID: 0000-0002-4625-452X AD - Verily Life Sciences, South San Francisco, California, USA. FAU - Barman, Poulami AU - Barman P AD - Verily Life Sciences, South San Francisco, California, USA. FAU - Verma, Nishant AU - Verma N AD - Verily Life Sciences, South San Francisco, California, USA. FAU - Allen, Hannah AU - Allen H AD - Verily Life Sciences, South San Francisco, California, USA. FAU - de Zambotti, Massimiliano AU - de Zambotti M AD - Center for Health Sciences, SRI International, California, USA. FAU - Baker, Fiona C AU - Baker FC AD - Center for Health Sciences, SRI International, California, USA. FAU - Arra, Nicole AU - Arra N AD - Center for Health Sciences, SRI International, California, USA. FAU - Sridhar, Niranjan AU - Sridhar N AD - Verily Life Sciences, South San Francisco, California, USA. FAU - Sullivan, Shannon S AU - Sullivan SS AD - Verily Life Sciences, South San Francisco, California, USA. AD - Department of Pediatrics, Division of Pulmonary, Asthma, and Sleep Medicine, Stanford University School of Medicine, California, USA. FAU - Plowman, Scooter AU - Plowman S AUID- ORCID: 0000-0002-1517-8245 AD - Verily Life Sciences, South San Francisco, California, USA. FAU - Rainaldi, Erin AU - Rainaldi E AD - Verily Life Sciences, South San Francisco, California, USA. FAU - Kapur, Ritu AU - Kapur R AD - Verily Life Sciences, South San Francisco, California, USA. AD - Department of Neurology, Radboud UMC, Nijmegen, the Netherlands. FAU - Shin, Sooyoon AU - Shin S AD - Verily Life Sciences, South San Francisco, California, USA. LA - eng GR - Verily Life Sciences/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250401 PL - England TA - J Sleep Res JT - Journal of sleep research JID - 9214441 SB - IM MH - Humans MH - Male MH - Adult MH - *Polysomnography/instrumentation/methods MH - Female MH - Middle Aged MH - Adolescent MH - Young Adult MH - Aged MH - *Sleep/physiology MH - *Wearable Electronic Devices MH - Sensitivity and Specificity MH - Sleep Stages/physiology MH - Reproducibility of Results OTO - NOTNLM OT - PSG OT - digital measures OT - mHealth OT - polysomnography OT - sleep OT - verily numetric watch OT - wearable technology EDAT- 2025/04/02 06:26 MHDA- 2025/09/16 00:34 CRDT- 2025/04/02 01:03 PHST- 2025/01/13 00:00 [revised] PHST- 2024/07/23 00:00 [received] PHST- 2025/02/27 00:00 [accepted] PHST- 2025/09/16 00:34 [medline] PHST- 2025/04/02 06:26 [pubmed] PHST- 2025/04/02 01:03 [entrez] AID - 10.1111/jsr.70036 [doi] PST - ppublish SO - J Sleep Res. 2025 Oct;34(5):e70036. doi: 10.1111/jsr.70036. Epub 2025 Apr 1. PMID- 40169924 OWN - NLM STAT- MEDLINE DCOM- 20250611 LR - 20261010 IS - 1476-5497 (Electronic) IS - 0307-0565 (Linking) VI - 49 IP - 6 DP - 2025 Jun TI - Development and validation of a machine learning model for predicting pediatric metabolic syndrome using anthropometric and bioelectrical impedance parameters. PG - 1159-1165 LID - 10.1038/s41366-025-01761-1 [doi] AB - OBJECTIVE: Metabolic syndrome (MS) is a risk factor for cardiovascular diseases, and its prevalence is increasing among children and adolescents. This study developed a machine learning model to predict MS using anthropometric and bioelectrical impedance analysis (BIA) parameters, highlighting its ability to handle complex, nonlinear variable relationships more effectively than traditional methods such as logistic regression. METHODS: The study included 359 youths from the Korea National Health and Nutrition Examination Survey (KNHANES; 16 MS, 343 normal) and 174 youths from real-world clinical data (66 MS, 108 normal). Model 1 used anthropometric data, Model 2 used BIA parameters, and Model 3 combined both. The eXtreme Gradient Boosting trained the models, and area under the receiver operating characteristic curve (AUC) evaluated performance. Shapley value analysis was applied to assess the contribution of each parameter to the model's prediction. RESULTS: The AUCs for Models 1, 2, and 3 were 0.75, 0.66, and 0.90, respectively, in the KNHANES dataset, and 0.56, 0.61, and 0.74, respectively, in the real-world dataset. In pairwise comparison, Model 3 outperformed both Model 1 and Model 2 in both the KNHANES dataset (Model 1 vs. Model 3, p = 0.026; Model 2 vs. Model 3, p = 0.033) and the real-world dataset (Model 1 vs. Model 3, p = 0.035; Model 2 vs. Model 3, p = 0.008). Body fat mass was identified as the most significant contributor to Model 3. CONCLUSION: The integrated model using both anthropometric and BIA parameters demonstrated strong predictability for pediatric MS, underlining its potential as an effective screening tool for MS in both clinical and general populations. CI - (c) 2025. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Choi, Youngha AU - Choi Y AUID- ORCID: 0000-0002-1607-6048 AD - Department of Pediatrics, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Lee, Kanghyuck AU - Lee K AD - Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. FAU - Seol, Eun Gyung AU - Seol EG AD - Department of Pediatrics, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, Republic of Korea. FAU - Kim, Joon Young AU - Kim JY AD - Department of Pediatrics, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Lee, Eun Byoul AU - Lee EB AD - Department of Pediatrics, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, Republic of Korea. FAU - Chae, Hyun Wook AU - Chae HW AUID- ORCID: 0000-0001-5016-8539 AD - Department of Pediatrics, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Ko, Taehoon AU - Ko T AUID- ORCID: 0000-0002-4045-0036 AD - Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. thko@catholic.ac.kr. AD - Department of Medical Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. thko@catholic.ac.kr. AD - CMC Institute for Basic Medical Science, The Catholic Medical Center of The Catholic University of Korea, Seoul, Republic of Korea. thko@catholic.ac.kr. FAU - Song, Kyungchul AU - Song K AUID- ORCID: 0000-0002-8497-5934 AD - Department of Pediatrics, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. endosong@yuhs.ac. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250401 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 SB - IM MH - Humans MH - *Electric Impedance MH - *Machine Learning MH - *Metabolic Syndrome/diagnosis/epidemiology MH - Male MH - Female MH - Child MH - Adolescent MH - *Anthropometry/methods MH - Republic of Korea/epidemiology MH - Nutrition Surveys COIS- Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: All methods were performed in accordance with the relevant guidelines and regulations. This study was conducted according to the Declaration of Helsinki and was approved by the Institutional Review Board of Yonsei University Gangnam Severance Hospital (IRB No. 3-2024-0220). For KNHANES participants, informed consent was obtained as part of the national survey protocol. For Yongin Severance Hospital patients, the requirement for informed consent was waived by the IRB due to the retrospective nature of the study. EDAT- 2025/04/02 00:25 MHDA- 2025/06/12 00:38 CRDT- 2025/04/01 23:44 PHST- 2024/11/26 00:00 [received] PHST- 2025/03/20 00:00 [accepted] PHST- 2025/03/04 00:00 [revised] PHST- 2025/06/12 00:38 [medline] PHST- 2025/04/02 00:25 [pubmed] PHST- 2025/04/01 23:44 [entrez] AID - 10.1038/s41366-025-01761-1 [pii] AID - 10.1038/s41366-025-01761-1 [doi] PST - ppublish SO - Int J Obes (Lond). 2025 Jun;49(6):1159-1165. doi: 10.1038/s41366-025-01761-1. Epub 2025 Apr 1. PMID- 40168347 OWN - NLM STAT- MEDLINE DCOM- 20250515 LR - 20260924 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 4 DP - 2025 TI - Can we use lower extremity joint moments predicted by the artificial intelligence model during walking in patients with cerebral palsy in the clinical gait analysis? PG - e0320793 LID - 10.1371/journal.pone.0320793 [doi] LID - e0320793 AB - Several studies have highlighted the advantages of employing artificial intelligence (AI) models in gait analysis. However, the credibility and practicality of integrating these models into clinical gait routines remain uncertain. This study critically evaluates an AI model's ability to predict lower extremity joint moments during gait in patients with cerebral palsy (CP). We employed a three-step approach to assess the feasibility of a previously developed AI model that predicted joint moments during walking for 622 patients with CP, using joint kinematics as input. First, we established clinically relevant thresholds for lower extremity joint moments, categorizing into three labels: acceptable (Green), acceptable with caution (Yellow), and unacceptable (Red). This categorization was based on the normalized root mean square error (nRMSE) between lab-measured and predicted joint moments. We explored the relationship between gait kinematics and joint moments by correlating the kinematic inputs with their respective output labels. Finally, we developed a linear discrimination analysis (LDA) model to predict labels for newly predicted joint. Assessing the validity of thresholds, an ANOVA one-way analysis and Bonferroni post-hoc statistical tests were performed to find significant differences between the nRMSE values for each label. The hip joint exhibited the largest population of Green labels (84%), while the ankle joint had the smallest (50%). Regressive differences in joint kinematics and gait profile scores were observed across all labels. The LDA model achieved an accuracy of 85.2% and an F-score of 92% for predicting Green label in hip joint moment. Additionally, more severe patient conditions were associated with an increase in Red-labeled predictions. Our findings highlight significant differences in nRMSE among labels, demonstrating the effectiveness of the proposed thresholds for labeling joint moments. Overall, the AI model's performance was rated as moderate, and the three-step approach proved valuable for assessing the feasibility of AI models in clinical settings. CI - Copyright: (c) 2025 Salami et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Salami, Firooz AU - Salami F AUID- ORCID: 0000-0001-6275-3962 AD - Clinic for Orthopedics and Trauma Surgery, Heidelberg University Hospital, Heidelberg, Germany. FAU - Ozates, Mustafa Erkam AU - Ozates ME AD - Department of Electrical Electronics Engineering, Faculty of Engineering, Turkish-German University, Istanbul, Turkey. FAU - Arslan, Yunus Ziya AU - Arslan YZ AUID- ORCID: 0000-0002-1861-9368 AD - Department of Robotics and Intelligent Systems, Institute of Graduate Studies in Science and Engineering, Turkish-German University, Istanbul, Turkey. FAU - Wolf, Sebastian Immanuel AU - Wolf SI AUID- ORCID: 0000-0003-3921-6629 AD - Clinic for Orthopedics and Trauma Surgery, Heidelberg University Hospital, Heidelberg, Germany. LA - eng PT - Journal Article DEP - 20250401 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology MH - Male MH - Female MH - Biomechanical Phenomena MH - *Artificial Intelligence MH - *Gait Analysis/methods MH - *Walking/physiology MH - *Lower Extremity/physiopathology MH - Child MH - Adolescent MH - *Gait/physiology MH - Young Adult MH - Adult MH - Child, Preschool PMC - PMC11960883 COIS- The authors have declared that no competing interests exist. EDAT- 2025/04/01 18:24 MHDA- 2025/04/01 18:25 PMCR- 2025/04/01 CRDT- 2025/04/01 13:43 PHST- 2024/11/07 00:00 [received] PHST- 2025/02/24 00:00 [accepted] PHST- 2025/04/01 18:25 [medline] PHST- 2025/04/01 18:24 [pubmed] PHST- 2025/04/01 13:43 [entrez] PHST- 2025/04/01 00:00 [pmc-release] AID - PONE-D-24-49582 [pii] AID - 10.1371/journal.pone.0320793 [doi] PST - epublish SO - PLoS One. 2025 Apr 1;20(4):e0320793. doi: 10.1371/journal.pone.0320793. eCollection 2025. PMID- 40168079 OWN - NLM STAT- MEDLINE DCOM- 20250703 LR - 20250709 IS - 2063-5303 (Electronic) IS - 2062-5871 (Print) IS - 2062-5871 (Linking) VI - 14 IP - 2 DP - 2025 Jul 2 TI - Exercise addiction and psychosocial health risks among adolescent athletes: Focus on sport type and performance level. PG - 1095-1106 LID - 10.1556/2006.2025.00024 [doi] AB - AIM: Exercise addiction is a compulsive need to engage in physical activity despite potential negative consequences. This study aims to analyze adolescents' psychosocial health in relation to the risk of exercise addiction, focusing on competition levels, sport types, gender, and age. METHODS: A cross-sectional study was conducted with 7,596 participants (44.2% girls) aged 11-19. Data on physical activity (PAQ-C and PAQ-A), sleep quality (PSQI), anxiety (SAS), depression symptoms (BDI-II), eating disorders (EDI-3), and health-related quality of life (KIDSCREEN-52) were collected via validated questionnaires. The prevalence of exercise addiction risk (EAI) was assessed, and differences based on competition level, sport type, gender, and age were analyzed. Gamma GLMs factors-adjusted were used for statistical comparisons. RESULTS: 6.4% of adolescents in non-competitive sports and 15.6% in competitive sports showed a risk of exercise addiction. The risk was higher in boys, but the difference diminished at higher competition levels. The risk of addiction increased notably in late adolescence. Competitive athletes, especially at high levels, were at greater risk compared to noncompetitive athletes. Those in individual sports were at higher risk than those in team sports. Adolescents at risk of exercise addiction reported poorer mental health, including sleep quality (beta = 1.62, p < 0.001), anxiety (beta = 3.58, p < 0.001), depression (beta = 2.283, p < 0.001), and eating disorders (beta = 3.101, p < 0.001). CONCLUSIONS: Exercise addiction is a significant concern among adolescents, especially in competitive and individual sports. It is associated with poorer mental health outcomes, emphasizing the need for targeted interventions to reduce the risk of addiction and promote holistic health in adolescent athletes. FAU - Mayolas-Pi, Carmen AU - Mayolas-Pi C AUID- ORCID: 0000-0003-0721-2447 AD - 1Faculty of Health and Sport Sciences, University of Zaragoza, Zaragoza, Spain. AD - 2Human Movement Research Group, Zaragoza, Spain. FAU - Sitko, Sebastian AU - Sitko S AUID- ORCID: 0000-0003-0455-6172 AD - 1Faculty of Health and Sport Sciences, University of Zaragoza, Zaragoza, Spain. AD - 2Human Movement Research Group, Zaragoza, Spain. FAU - Pano-Rodriguez, Alvaro AU - Pano-Rodriguez A AUID- ORCID: 0000-0002-6816-6571 AD - 3Faculty of Education, Psychology and Social Work, University of Lleida, Lleida, Spain. FAU - Lopez-Laval, Isaac AU - Lopez-Laval I AUID- ORCID: 0000-0002-9304-3709 AD - 1Faculty of Health and Sport Sciences, University of Zaragoza, Zaragoza, Spain. AD - 2Human Movement Research Group, Zaragoza, Spain. FAU - Reverter-Masia, Joaquin AU - Reverter-Masia J AUID- ORCID: 0000-0002-9441-2764 AD - 2Human Movement Research Group, Zaragoza, Spain. AD - 3Faculty of Education, Psychology and Social Work, University of Lleida, Lleida, Spain. FAU - Legaz-Arrese, Alejandro AU - Legaz-Arrese A AUID- ORCID: 0000-0003-2644-9386 AD - 1Faculty of Health and Sport Sciences, University of Zaragoza, Zaragoza, Spain. AD - 2Human Movement Research Group, Zaragoza, Spain. LA - eng PT - Journal Article DEP - 20250401 PL - Hungary TA - J Behav Addict JT - Journal of behavioral addictions JID - 101602037 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - *Behavior, Addictive/epidemiology/psychology MH - Cross-Sectional Studies MH - *Exercise/psychology MH - *Athletes/psychology/statistics & numerical data MH - Child MH - Young Adult MH - Anxiety/epidemiology MH - Depression/epidemiology MH - Feeding and Eating Disorders/epidemiology MH - *Sports/statistics & numerical data MH - Quality of Life MH - *Athletic Performance MH - *Adolescent Behavior/psychology MH - Sleep Quality MH - Sex Factors MH - Risk Factors PMC - PMC12231450 OTO - NOTNLM OT - adolescents OT - competitive sports OT - individual sports OT - psychosocial health OT - risk of exercise addiction OT - team sports COIS- Conflict of interest: The authors report there are no competing interests to declare. EDAT- 2025/04/01 18:24 MHDA- 2025/07/03 06:27 PMCR- 2025/04/01 CRDT- 2025/04/01 12:03 PHST- 2024/06/25 00:00 [received] PHST- 2024/12/16 00:00 [revised] PHST- 2025/02/27 00:00 [revised] PHST- 2025/03/08 00:00 [accepted] PHST- 2025/07/03 06:27 [medline] PHST- 2025/04/01 18:24 [pubmed] PHST- 2025/04/01 12:03 [entrez] PHST- 2025/04/01 00:00 [pmc-release] AID - 10.1556/2006.2025.00024 [doi] PST - epublish SO - J Behav Addict. 2025 Apr 1;14(2):1095-1106. doi: 10.1556/2006.2025.00024. Print 2025 Jul 2. PMID- 40167582 OWN - NLM STAT- MEDLINE DCOM- 20250830 LR - 20260726 IS - 1552-4604 (Electronic) IS - 0091-2700 (Linking) VI - 65 IP - 9 DP - 2025 Sep TI - A Phenome-Wide Association Study of Marijuana Use and Circulating Biomarkers in the United States: National Health and Nutrition Examination Survey 2009-2018. PG - 1127-1134 LID - 10.1002/jcph.70022 [doi] AB - This study aimed to assess the associations between recent cannabis use and 49 biochemical biomarkers in a representative sample of American adults, using data from the 2009-2018 National Health and Nutrition Examination Survey. A phenotype-wide association study (PheWAS) was conducted to uncover new biomarkers linked to cannabis use. The analysis included 19,926 adults aged 18-59, with a mean age of 38.93 years (50.8% women), and 36.7% reporting recent cannabis use. Metabolic associations included higher high-density lipoprotein (HDL) cholesterol (3.51 mg/dL, 95% CI [2.50, 4.62]) and lower glycohemoglobin (-0.09%, 95% CI [-0.15, -0.04]) and glucose (-2.39 mg/dL, 95% CI [-4.07, -0.70]). Hematological findings included higher hemoglobin (0.09 g/dL, 95% CI [0.02, 0.16]), mean erythrocyte volume (1.46 fL, 95% CI [1.12, 1.80]), mean erythrocyte hemoglobin (0.46 pg, 95% CI [0.32, 0.60]), erythrocyte volume fraction (0.31%, 95% CI [0.11%, 0.50%]), and lower erythrocyte counts (-0.04 million cells/microL, 95% CI [-0.07, -0.02]). Serum chemistry associations included higher bicarbonate (0.20 mmol/L, 95% CI [0.06, 0.35]) and lower chloride (-0.47 mmol/L, 95% CI [-0.69, -0.24]). Associations were also observed with 25 hydroxyvitamin-3 (OHD3) (2.38 nmol/L, 95% CI [0.55, 4.22]) and epi-25OHD3 (0.40 nmol/L, 95% CI [0.15, 0.65]), and an inverse association with globulin (-0.03 g/dL, 95% CI [-0.06, -0.01]). Sensitivity analyses confirmed the robustness of these associations. Recent marijuana use is associated with diverse and complex phenotypes, several of which have not been previously evaluated. Further validation studies are warranted, this approach offers an opportunity to understand a comprehensive range of potential effects of marijuana use. CI - (c) 2025, The American College of Clinical Pharmacology. FAU - Zhang, Cancan AU - Zhang C AUID- ORCID: 0009-0006-1997-0893 AD - Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. FAU - Mostofsky, Elizabeth AU - Mostofsky E AD - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. FAU - Zhang, Hui AU - Zhang H AD - Department of Preventative Medicine, Division of Biostatistics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. FAU - Zhang, Bo AU - Zhang B AD - Department of Neurology and ICCTR Biostatistics and Research Design Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. FAU - Lindenberg, Julia AU - Lindenberg J AD - Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. FAU - Amat, Maelys J AU - Amat MJ AD - Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. FAU - Mukamal, Kenneth J AU - Mukamal KJ AD - Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. LA - eng PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20250401 PL - England TA - J Clin Pharmacol JT - Journal of clinical pharmacology JID - 0366372 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Adult MH - Nutrition Surveys MH - United States/epidemiology MH - Male MH - Middle Aged MH - Biomarkers/blood MH - Adolescent MH - Young Adult MH - *Marijuana Use/epidemiology/blood MH - Phenotype OTO - NOTNLM OT - National Health and Nutrition Examination Survey (NHANES) OT - biomarkers OT - cannabis OT - marijuana OT - phenotype-wide association study EDAT- 2025/04/01 11:40 MHDA- 2025/08/31 19:53 CRDT- 2025/04/01 11:03 PHST- 2025/01/06 00:00 [received] PHST- 2025/03/17 00:00 [accepted] PHST- 2025/08/31 19:53 [medline] PHST- 2025/04/01 11:40 [pubmed] PHST- 2025/04/01 11:03 [entrez] AID - 10.1002/jcph.70022 [doi] PST - ppublish SO - J Clin Pharmacol. 2025 Sep;65(9):1127-1134. doi: 10.1002/jcph.70022. Epub 2025 Apr 1. PMID- 40166610 OWN - NLM STAT- MEDLINE DCOM- 20250515 LR - 20250515 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 14 DP - 2025 TI - Estimating sodium and potassium intakes in a Portuguese adult population: can first-morning void urine replace 24-hour urine samples? PG - e29 LID - 10.1017/jns.2025.16 [doi] LID - e29 AB - This study aimed to assess the extent to which first-morning void (FMV) urine samples can estimate sodium and potassium excretion compared with 24-hour (24-h) urine samples at the population level. We conducted a cross-sectional study collecting urine samples (FMV and 24-h) and two non-consecutive 24-h dietary recalls in a sub-sample from the Portuguese IAN-AF sampling frame. Six predictive equations were used to estimate 24-h sodium and potassium excretion from FMV urine samples. Pearson correlation coefficients were calculated to compare the association between FMV and 24-h urine collections. Cross-classifications into tertiles were computed to calculate the agreement between measured and estimated excretion with and without calibration. Pearson correlation coefficients were calculated to compare the excretion estimation from FMV and reported intake from 24-h dietary recalls. Bland-Altman plots assessed the agreement between two-day dietary recall and the best-performing calibrated equation. Data from eighty-six subjects aged 18-84 were analysed. Estimated sodium and potassium concentrations from the predictive equations moderate or strongly correlated with the measured 24-h urine samples. The Toft equation was the most predictive and reliable, displaying a moderate correlation (r=0.655) with no risk of over or underestimation of sodium excretion (p=0.096). Tanaka and Kawasaki equations showed a similar moderate correlation (r=0.54 and r=0.58, respectively) but tended to underestimate the 24-h urine excretion of potassium (p<0.001). Calibrated predictive equations using FMV urine samples provide a moderately accurate alternative and resource-efficient option for large-scale nutritional epidemiology studies when 24-h urine collection is impractical. CI - (c) The Author(s) 2025. FAU - Goios, Ana Carolina Lages AU - Goios ACL AUID- ORCID: 0000-0003-2212-0786 AD - Faculty of Nutrition and Food Sciences, University of Porto, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal. AD - Epidemiology Research Unit, Institute of Public Health, University of Porto, Rua das Taipas 135, 4050-091 Porto, Portugal. FAU - Severo, Milton AU - Severo M AD - Epidemiology Research Unit, Institute of Public Health, University of Porto, Rua das Taipas 135, 4050-091 Porto, Portugal. AD - Instituto de Ciencias Biomedicas Abel Salazar, Universidade do Porto, Rua Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal. FAU - Lopes, Carla Maria Moura AU - Lopes CMM AD - Epidemiology Research Unit, Institute of Public Health, University of Porto, Rua das Taipas 135, 4050-091 Porto, Portugal. AD - Laboratorio para a Investigacao Integrativa e Translacional em Saude Populacional (ITR), Universidade do Porto, Rua das Taipas, n◦ 135, 4050-600 Porto, Portugal. AD - Department of Public Health and Forensic Sciences, and Medical Education, Faculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal. FAU - Torres, Duarte Paulo Martins AU - Torres DPM AD - Faculty of Nutrition and Food Sciences, University of Porto, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal. AD - Epidemiology Research Unit, Institute of Public Health, University of Porto, Rua das Taipas 135, 4050-091 Porto, Portugal. AD - Laboratorio para a Investigacao Integrativa e Translacional em Saude Populacional (ITR), Universidade do Porto, Rua das Taipas, n◦ 135, 4050-600 Porto, Portugal. LA - eng PT - Journal Article DEP - 20250326 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 RN - 0 (Potassium, Dietary) RN - 0 (Sodium, Dietary) RN - 9NEZ333N27 (Sodium) RN - RWP5GA015D (Potassium) SB - IM MH - Humans MH - Adult MH - Portugal MH - Middle Aged MH - Male MH - Female MH - Cross-Sectional Studies MH - Aged MH - Young Adult MH - *Potassium, Dietary/urine/administration & dosage MH - *Sodium, Dietary/administration & dosage/urine MH - Adolescent MH - Aged, 80 and over MH - *Urine Specimen Collection/methods MH - *Sodium/urine MH - *Potassium/urine MH - Urinalysis/methods MH - Diet PMC - PMC11955307 OTO - NOTNLM OT - 24-h urine excretion OT - 24-h, 24-hour OT - BMI, body mass index OT - CI, confidence interval OT - CVD, cardiovascular diseases OT - D, day OT - Dietary intake OT - FMV, first-morning void OT - IAN-AF, National Food, Nutrition and Physical Activity Survey OT - PABA, para-aminobenzoic acid OT - Potassium OT - SD, standard deviationl OT - Sodium OT - Spot urine samples OT - USA, United States of America OT - Urine specimen collection OT - WHO, World Health Organization COIS- The authors declare none. EDAT- 2025/04/01 06:26 MHDA- 2025/04/01 06:27 PMCR- 2025/01/01 CRDT- 2025/04/01 05:04 PHST- 2024/03/21 00:00 [received] PHST- 2025/01/29 00:00 [revised] PHST- 2025/02/07 00:00 [accepted] PHST- 2025/04/01 06:27 [medline] PHST- 2025/04/01 06:26 [pubmed] PHST- 2025/04/01 05:04 [entrez] PHST- 2025/01/01 00:00 [pmc-release] AID - S2048679025000163 [pii] AID - 10.1017/jns.2025.16 [doi] PST - epublish SO - J Nutr Sci. 2025 Mar 26;14:e29. doi: 10.1017/jns.2025.16. eCollection 2025. PMID- 40165673 OWN - NLM STAT- MEDLINE DCOM- 20250527 LR - 20250527 IS - 2191-0278 (Electronic) IS - 0334-0139 (Linking) VI - 37 IP - 2 DP - 2025 Apr 1 TI - Bridging the gap: a study on substance use among the adolescents in a rural area of Jaipur. PG - 97-106 LID - 10.1515/ijamh-2024-0163 [doi] AB - OBJECTIVES: To find out the prevalence of substance use and associated factors among adolescents of the rural area of Jaipur, Rajasthan. METHODS: This cross-sectional study was carried out in 461 adolescents of rural area Achrol of Jaipur using systematic random sampling technique. Sample size of 461 was calculated using 4PQ/L2 with a prevalence of substance use at 15.8 %. We utilized a pre-developed, pre-validated, semi-structured questionnaire based on the WHO steps questionnaire with specific adaptations was used. The data was analyzed using SPSS Software version 23, and the Chi-square test was employed for qualitative data analysis. RESULTS: The findings revealed that the average (Mean) age of the study participants was 14.1 +/- 2.1. Maximum of the study participants (53.3 %) were in the age group of 14-16 years. Males were more (69.6 %) as compared to females (30.3 %). The overall prevalence of substance use was 26.4 % among the study participants. About one fourth (22.2 %) of participants had consumed alcohol in the past. Only (2.1 %) of them were daily smokers. Majority (95.8 %) of the study participants had never consumed any type of Intravenous drug. Factors like family history of substance abuse, high body mass index, low physical activity were statistically significantly associated with different forms of substance use. CONCLUSIONS: The study population exhibited a high prevalence of substance use and related risk factors. Important risk factors for different forms of substance use prevalent in the study population included male gender, obesity, family history of substance use, and low levels of physical activity. CI - (c) 2025 the author(s), published by De Gruyter, Berlin/Boston. FAU - Kumar, Ashwani AU - Kumar A AD - Department of Community Medicine, National Institute of Medical Sciences, Jaipur, Rajasthan, India. FAU - Rathore, Sunil Singh AU - Rathore SS AUID- ORCID: 0009-0007-3235-8727 AD - Department of Community Medicine, National Institute of Medical Sciences & Research, Jaipur, India. FAU - Dhaka, Rohit AU - Dhaka R AD - Department of Community Medicine, ESIC Medical College and Hospital, Faridabad, Haryana, India. FAU - Singh, Sunil Kumar AU - Singh SK AUID- ORCID: 0000-0001-9605-8378 AD - Department of Community Medicine, Shri Atal Bihari Vajpayee Government Medical College, Chhainsa, Faridabad, Haryana, India. LA - eng PT - Journal Article DEP - 20250402 PL - Germany TA - Int J Adolesc Med Health JT - International journal of adolescent medicine and health JID - 8506960 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - *Substance-Related Disorders/epidemiology MH - Cross-Sectional Studies MH - *Rural Population/statistics & numerical data MH - India/epidemiology MH - Prevalence MH - Surveys and Questionnaires MH - Risk Factors MH - *Adolescent Behavior OTO - NOTNLM OT - Jaipur OT - adolescents OT - alcohol OT - intravenous drugs OT - smoking tobacco OT - substance use EDAT- 2025/04/01 06:26 MHDA- 2025/05/27 12:43 CRDT- 2025/04/01 04:12 PHST- 2024/10/11 00:00 [received] PHST- 2025/03/08 00:00 [accepted] PHST- 2025/05/27 12:43 [medline] PHST- 2025/04/01 06:26 [pubmed] PHST- 2025/04/01 04:12 [entrez] AID - ijamh-2024-0163 [pii] AID - 10.1515/ijamh-2024-0163 [doi] PST - epublish SO - Int J Adolesc Med Health. 2025 Apr 2;37(2):97-106. doi: 10.1515/ijamh-2024-0163. eCollection 2025 Apr 1. PMID- 40165330 OWN - NLM STAT- MEDLINE DCOM- 20250704 LR - 20260824 IS - 1098-108X (Electronic) IS - 0276-3478 (Linking) VI - 58 IP - 7 DP - 2025 Jul TI - Sudden Onset Disordered Eating Behaviors and Appetite Issues in a Local Clinical Cohort of Children With Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). PG - 1219-1232 LID - 10.1002/eat.24388 [doi] AB - OBJECTIVE: Abrupt onset restrictive food intake can be a cardinal symptom of pediatric acute-onset neuropsychiatric syndrome (PANS). However, few reports detail eating restriction patterns and baseline eating behaviors in patients with PANS, which we aim to address. Additionally, we aim to compare PANS eating restriction with ARFID. METHODS: Retrospective chart review of 130 patients with PANS, aged 4-18 years, presenting for initial assessment at Stanford's PANS/Immune Behavioral Health (IBH) Clinic. Data were abstracted from electronic medical records (EMR) and parent/child questionnaires which included symptom ratings and psychometric scores. Baseline eating restriction and abrupt onset changes in eating associated with PANS flares were studied. RESULTS: Over half (56%) of the PANS patients developed abrupt-onset restricted food intake during flare prompting clinic entry. Of youth with restricted intake, 48% had selective eating, 41% had low appetite/interest in food, 37% feared aversive consequences (26% swallowing/choking/vomiting concerns, 16% feared contamination), and 4% overweight concerns. Youth with restricted intake had high levels of emotional lability and/or depression (96%), irritability, aggression, or oppositional behaviors (89%), behavioral/developmental regression (60%), cognitive impairment (69%), and sensory amplification (64%). Baseline eating restriction was noted in 16 (12%), with 9 altering eating behaviors during flare. CONCLUSIONS: Eating restriction is common during PANS flares, reasons align with 3 main presentations of ARFID: Selective eating, low appetite/interest, and fear of aversive consequences. High levels of other neuropsychiatric symptoms are noted in youth with PANS and eating restriction during flares. Twelve percent of PANS patients have baseline eating restriction; over half of whom alter eating behaviors during the flare. CI - (c) 2025 Wiley Periodicals LLC. FAU - Kapphahn, Cynthia AU - Kapphahn C AUID- ORCID: 0000-0002-5667-4157 AD - Division of Adolescent Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California, USA. FAU - Peet, Brianna AU - Peet B AD - Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California, USA. AD - Stanford PANS Clinic and Research Program at Lucile Packard Children's Hospital, Menlo Park, California, USA. FAU - Gao, Jaynelle AU - Gao J AD - Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California, USA. AD - Stanford PANS Clinic and Research Program at Lucile Packard Children's Hospital, Menlo Park, California, USA. FAU - Chan, Avis AU - Chan A AD - Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California, USA. AD - Stanford PANS Clinic and Research Program at Lucile Packard Children's Hospital, Menlo Park, California, USA. FAU - Farhadian, Bahare AU - Farhadian B AD - Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California, USA. AD - Stanford PANS Clinic and Research Program at Lucile Packard Children's Hospital, Menlo Park, California, USA. FAU - Ma, Meiqian AU - Ma M AD - Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California, USA. AD - Stanford PANS Clinic and Research Program at Lucile Packard Children's Hospital, Menlo Park, California, USA. FAU - Silverman, Melissa AU - Silverman M AD - Stanford PANS Clinic and Research Program at Lucile Packard Children's Hospital, Menlo Park, California, USA. AD - Division of Child and Adolescent Psychiatry and Child Development, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA. FAU - Tran, Paula AU - Tran P AD - Stanford PANS Clinic and Research Program at Lucile Packard Children's Hospital, Menlo Park, California, USA. AD - Division of Child and Adolescent Psychiatry and Child Development, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA. FAU - Schlenk, Noelle AU - Schlenk N AD - Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California, USA. AD - Stanford PANS Clinic and Research Program at Lucile Packard Children's Hospital, Menlo Park, California, USA. FAU - Thienemann, Margo AU - Thienemann M AD - Stanford PANS Clinic and Research Program at Lucile Packard Children's Hospital, Menlo Park, California, USA. AD - Division of Child and Adolescent Psychiatry and Child Development, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA. FAU - Frankovich, Jennifer AU - Frankovich J AD - Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California, USA. AD - Stanford PANS Clinic and Research Program at Lucile Packard Children's Hospital, Menlo Park, California, USA. LA - eng PT - Journal Article DEP - 20250331 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 RN - Pediatric acute-onset neuropsychiatric syndrome SB - IM MH - Humans MH - Child MH - Female MH - Male MH - Adolescent MH - Retrospective Studies MH - Child, Preschool MH - *Feeding and Eating Disorders/psychology MH - *Feeding Behavior/psychology MH - *Appetite/physiology MH - *Obsessive-Compulsive Disorder MH - Autoimmune Diseases OTO - NOTNLM OT - avoidant restrictive food intake disorder (ARFID) OT - food phobia OT - neuropsychiatric OT - obsessive-compulsive disorder (OCD) OT - pediatric acute-onset neuropsychiatric syndrome (PANS) OT - restricted eating OT - selective eating OT - sensory sensitivity OT - weight loss EDAT- 2025/04/01 06:26 MHDA- 2025/07/04 12:43 CRDT- 2025/04/01 01:24 PHST- 2025/01/06 00:00 [revised] PHST- 2024/09/29 00:00 [received] PHST- 2025/01/16 00:00 [accepted] PHST- 2025/07/04 12:43 [medline] PHST- 2025/04/01 06:26 [pubmed] PHST- 2025/04/01 01:24 [entrez] AID - 10.1002/eat.24388 [doi] PST - ppublish SO - Int J Eat Disord. 2025 Jul;58(7):1219-1232. doi: 10.1002/eat.24388. Epub 2025 Mar 31. PMID- 40163706 OWN - NLM STAT- MEDLINE DCOM- 20250522 LR - 20261008 IS - 1749-6632 (Electronic) IS - 0077-8923 (Print) IS - 0077-8923 (Linking) VI - 1547 IP - 1 DP - 2025 May TI - Social media are many things: Addressing the components and patterns of adolescent social media use. PG - 24-32 LID - 10.1111/nyas.15326 [doi] AB - Adolescent development is increasingly shaped by social media contexts, with implications for well-being. In this commentary, we discuss and present conceptual and methodological alternatives for two persistent limitations in prior research. First, most prior work measures screen time, implicitly treating social media as a monolith. Emerging research highlights that social media are multifaceted environments where youth encounter diverse experiences. We advocate for more work taking this nuanced approach and for the development of a comprehensive taxonomic framework that categorizes specific online experiences afforded by social media features and content. To support this approach, we call for the development of psychometrically rigorous self-report scales to measure affective and cognitive social media experiences and for innovative behavioral observation techniques. Second, research that considers specific online experiences typically focuses on one in isolation. We argue that a holistic, interactionist approach to understanding human development requires integrating the numerous positive and negative online experiences that co-occur in distinct patterns for diverse adolescents. We discuss the merits of mixture models as one potential analytic solution to address configurations of online experiences and systematically model heterogeneity among youth. These conceptual and methodological shifts can lead to targeted interventions and policies that recognize the interactive effects of digital experiences. CI - (c) 2025 The New York Academy of Sciences. FAU - Maheux, Anne J AU - Maheux AJ AUID- ORCID: 0000-0003-1308-5798 AD - Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Winston National Center on Technology Use, Brain, and Psychological Development, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Maes, Chelly AU - Maes C AD - Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Winston National Center on Technology Use, Brain, and Psychological Development, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Burnell, Kaitlyn AU - Burnell K AD - Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Winston National Center on Technology Use, Brain, and Psychological Development, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Bauer, Daniel J AU - Bauer DJ AD - Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Prinstein, Mitchell J AU - Prinstein MJ AD - Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Winston National Center on Technology Use, Brain, and Psychological Development, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Telzer, Eva H AU - Telzer EH AD - Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Winston National Center on Technology Use, Brain, and Psychological Development, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. LA - eng PT - Journal Article PT - Review DEP - 20250331 PL - United States TA - Ann N Y Acad Sci JT - Annals of the New York Academy of Sciences JID - 7506858 SB - IM MH - *Social Media MH - Humans MH - Adolescent MH - *Adolescent Behavior/psychology MH - *Adolescent Development PMC - PMC13355886 OTO - NOTNLM OT - adolescence OT - measurement OT - mixture models OT - social media OT - well-being COIS- E.H.T. and M.J.P. are currently serving as expert witnesses in ongoing social media litigation. K.B. has served as a paid consultant in US social media litigation. The other authors declare no competing interests. EDAT- 2025/03/31 21:17 MHDA- 2025/05/22 12:30 PMCR- 2026/07/11 CRDT- 2025/03/31 15:03 PHST- 2025/05/22 12:30 [medline] PHST- 2025/03/31 21:17 [pubmed] PHST- 2025/03/31 15:03 [entrez] PHST- 2026/07/11 00:00 [pmc-release] AID - NYAS15326 [pii] AID - 10.1111/nyas.15326 [doi] PST - ppublish SO - Ann N Y Acad Sci. 2025 May;1547(1):24-32. doi: 10.1111/nyas.15326. Epub 2025 Mar 31. PMID- 40161026 OWN - NLM STAT- MEDLINE DCOM- 20250331 LR - 20250613 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - A physical activity and socioemotional intervention for residents of a large vulnerable community in Brazil during the COVID-19 pandemic: a randomized controlled study. PG - 1463401 LID - 10.3389/fpubh.2025.1463401 [doi] LID - 1463401 AB - INTRODUCTION: The COVID-19 pandemic exacerbated mental health issues, particularly in vulnerable communities. Non-psychiatric interventions, including psychological emotional regulation, contemplative practices, and physical activity, can be powerful tools for improving mental health, especially in vulnerable populations. The present study evaluates the effect of a novel low-cost Socioemotional and Physical Activity Intervention in a Brazilian large vulnerable community during the pandemic's final period. MATERIALS AND METHODS: Participants were adults (18 to 60 years of age) that resided in the Paraisopolis, the third largest favela in Brazil. Recruitment was done through advertising via mobile messaging. Participants were divided into two groups, Intervention (Group I) or Waiting List Control (Group C). Group I participants underwent an in-person Multidimensional Intervention of 1 h per week, for 12 weeks, which was composed of socioemotional skills learning and moderate physical activities, while Group C maintained their usual daily routines. All participants were evaluated before (T0) and after (T1) the Intervention. The evaluation included four validated questionnaires to assess mental health (DASS-21, PANAS, WHO-5 and BRS), IPAQ for evaluating physical activity levels and a physical fitness assessment, which provided quantitative data. A semi-structured interview was also done, which provided qualitative data and was analyzed using a reflexive thematic analysis. RESULTS: Quantitative data was collected from 88 participants, 43 from Group I and 45 from Group C. We observed a reduction in the scores for depression (DASS-21; Mean difference between evaluations [MD] = -3.2 [+/- 1.13, SEM], p = 0.006) and negative affects (PANAS, MD = -2.7 [+/- 0.97], p = 0.012) observed only in the participants of the I group in T1 compared to T0, but not for the C group. We also found a reduction in systolic arterial blood pressure in hypertensive or pre-hypertensive participants after exercise (Group I n = 28; -7.0 [+/- 2.8] mmHg, p = 0.014), an increase in physical endurance (walk test, MD = +56.0 [+/-8.7] m, p < 0.001) and flexibility (sit and reach test, MD = +5.12 [+/-0.85] cm, p < 0.001) only in the I group on T1, compared to T0. The reflexive thematic analysis results suggest that the Intervention not only alleviated negative emotional states, such as anxiety and sadness, but also provided a notable enhancement in participant's physical vitality, corroborating and complementing the quantitative analysis results. CONCLUSION: The results presented here indicate that the Intervention presented here has the potential to reduce symptoms correlated with mental disorders and improve physical fitness in residents of a large vulnerable community. CI - Copyright (c) 2025 Torres-Cruz, Moura-Alves, Lima, King, dos Santos, Almeida, Callamari, Kolchraiber, Marega, Atalla, Amaro, Sato and Kozasa. FAU - Torres-Cruz, Mateus AU - Torres-Cruz M AD - Hospital Israelita Albert Einstein, Sao Paulo, Brazil. FAU - Moura-Alves, Mariana AU - Moura-Alves M AD - Hospital Israelita Albert Einstein, Sao Paulo, Brazil. FAU - Lima, Renata Pereira AU - Lima RP AD - Hospital Israelita Albert Einstein, Sao Paulo, Brazil. AD - University of Chichester, Chichester, United Kingdom. FAU - King, Rachel AU - King R AD - University of Chichester, Chichester, United Kingdom. FAU - Dos Santos, Cleber Aparecido AU - Dos Santos CA AD - Hospital Israelita Albert Einstein, Sao Paulo, Brazil. FAU - Almeida, Thiago da Silva AU - Almeida TDS AD - Hospital Israelita Albert Einstein, Sao Paulo, Brazil. FAU - Callamari, Frederico Barao AU - Callamari FB AD - Fred Barao Desenvolvimento Humano, Sao Paulo, Brazil. FAU - Kolchraiber, Flavia Cristiane AU - Kolchraiber FC AD - Hospital Israelita Albert Einstein, Sao Paulo, Brazil. FAU - Marega, Marcio AU - Marega M AD - Hospital Israelita Albert Einstein, Sao Paulo, Brazil. FAU - Atalla, Marcio Henrique AU - Atalla MH AD - Casa do BemStar, Sao Paulo, Brazil. FAU - Amaro, Edson AU - Amaro E AD - Hospital Israelita Albert Einstein, Sao Paulo, Brazil. FAU - Sato, Joao Ricardo AU - Sato JR AD - Hospital Israelita Albert Einstein, Sao Paulo, Brazil. AD - Center for Mathematics, Computing and Cognition, Universidade Federal do ABC, Sao Bernardo do Campo, Brazil. FAU - Kozasa, Elisa Harumi AU - Kozasa EH AD - Hospital Israelita Albert Einstein, Sao Paulo, Brazil. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20250314 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Brazil/epidemiology MH - *COVID-19/psychology/epidemiology MH - Adult MH - Female MH - Male MH - *Exercise/psychology MH - Middle Aged MH - *Vulnerable Populations/psychology MH - *Mental Health MH - Young Adult MH - Adolescent MH - SARS-CoV-2 MH - Pandemics PMC - PMC11951185 OTO - NOTNLM OT - COVID-19 OT - contemplative practices OT - depression OT - emotion regulation OT - exercise OT - favela OT - meditation OT - vulnerable populations COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2025/03/31 21:16 MHDA- 2025/03/31 21:17 PMCR- 2025/03/14 CRDT- 2025/03/31 06:14 PHST- 2024/07/11 00:00 [received] PHST- 2025/02/26 00:00 [accepted] PHST- 2025/03/31 21:17 [medline] PHST- 2025/03/31 21:16 [pubmed] PHST- 2025/03/31 06:14 [entrez] PHST- 2025/03/14 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1463401 [doi] PST - epublish SO - Front Public Health. 2025 Mar 14;13:1463401. doi: 10.3389/fpubh.2025.1463401. eCollection 2025. PMID- 40160026 OWN - NLM STAT- MEDLINE DCOM- 20250918 LR - 20250918 IS - 2233-6087 (Electronic) IS - 2233-6079 (Print) IS - 2233-6079 (Linking) VI - 49 IP - 5 DP - 2025 Sep TI - The Causal Relationship and Association between Biomarkers, Dietary Intake, and Diabetic Retinopathy: Insights from Mendelian Randomization and Cross-Sectional Study. PG - 1087-1105 LID - 10.4093/dmj.2024.0731 [doi] AB - BACKGRUOUND: Diabetic retinopathy (DR) is a major cause of vision loss, linked to hyperglycemia, oxidative stress, and inflammation. Despite advancements in DR treatments, approximately 40% of patients do not respond effectively, underscoring the need for novel, noninvasive biomarkers to predict DR risk and progression. This study investigates causal relationships between specific biomarkers, dietary factors, and DR development using Mendelian randomization (MR) and cross-sectional data. METHODS: We conducted a two-phase analysis combining MR and cross-sectional methods. First, MR analysis examined causal associations between 35 biomarkers, 226 dietary factors, and DR progression using data from the UK Biobank and Genome-Wide Association Study (GWAS) datasets. Second, a cross-sectional study with National Health and Nutrition Examination Survey (NHANES) and a clinical cohort from Tianjin Medical University Eye Hospital validated findings and explored biomarkers' predictive capabilities through a nomogram-based prediction model. RESULTS: MR analysis identified eight biomarkers (e.g., glycosylated hemoglobin [HbA1c], high-density lipoprotein cholesterol [HDL-C]) with significant causal links to DR. Inflammatory markers and metabolic factors, such as high glucose and HDL-C levels, were strongly associated with DR risk and progression. Specific dietary factors, like cheese intake, exhibited protective roles, while alcohol intake increased DR risk. Validation within NHANES and Tianjin cohorts supported these causal associations. CONCLUSION: This study elucidates causal relationships between biomarkers, dietary habits, and DR progression, emphasizing the potential for personalized dietary interventions to prevent or manage DR. Findings support the use of HDL-C, HbA1c, and dietary factors as biomarkers or therapeutics in DR, though further studies are needed for broader applicability. FAU - Cui, Xuehao AU - Cui X AD - John Van Geest Centre for Brain Repair and MRC Mitochondrial Biology Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. AD - Cambridge Eye Unit, Addenbrooke's Hospital, Cambridge University Hospitals, Cambridge, UK. AD - Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China. FAU - Wen, Dejia AU - Wen D AD - Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China. AD - Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin, China. AD - Tianjin Branch of National Clinical Research Center for Ocular Disease, Tianjin, China. FAU - Xiao, Jishan AU - Xiao J AD - Institute of Ophthalmology, University College London, London, UK. FAU - Li, Xiaorong AU - Li X AD - Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China. AD - Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin, China. AD - Tianjin Branch of National Clinical Research Center for Ocular Disease, Tianjin, China. LA - eng GR - Gates Cambridge Trust/ GR - Addenbrooke's Charitable Trust/ GR - Cambridge University Hospitals/ GR - NIHR 203312/NIHR Cambridge Biomedical Research Centre/ GR - 82171085/National Natural Science Foundation of China/ GR - TJYXZ-DXK-037A/Tianjin Key Medical Discipline (Specialty) Construction Project/ PT - Journal Article DEP - 20250331 PL - Korea (South) TA - Diabetes Metab J JT - Diabetes & metabolism journal JID - 101556588 RN - 0 (Biomarkers) RN - 0 (hemoglobin A1c protein, human) RN - 0 (Cholesterol, HDL) RN - 0 (Inflammation Mediators) RN - 0 (Blood Glucose) RN - 0 (Glycated Hemoglobin) SB - IM MH - Biomarkers/blood MH - Eating MH - *Diet/adverse effects MH - *Diabetic Retinopathy/epidemiology/etiology MH - Mendelian Randomization Analysis MH - Cross-Sectional Studies MH - UK Biobank MH - Genome-Wide Association Study MH - Nutrition Surveys MH - Nomograms MH - Retrospective Studies MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged MH - Aged MH - Aged, 80 and over MH - Case-Control Studies MH - Regression Analysis MH - China/epidemiology MH - United Kingdom/epidemiology MH - Risk Factors MH - *Cholesterol, HDL/blood MH - Inflammation Mediators/blood MH - *Blood Glucose/analysis MH - *Glycated Hemoglobin/analysis PMC - PMC12436034 OTO - NOTNLM OT - Biomarkers OT - Blindness OT - Cholesterol OT - Cross-sectional studies OT - Diabetic retinopathy OT - Genome-wide association study OT - Glucose COIS- CONFLICTS OF INTEREST No potential conflict of interest relevant to this article was reported. EDAT- 2025/03/31 20:04 MHDA- 2025/09/16 00:32 PMCR- 2025/09/01 CRDT- 2025/03/31 04:52 PHST- 2024/11/17 00:00 [received] PHST- 2024/12/12 00:00 [accepted] PHST- 2025/09/16 00:32 [medline] PHST- 2025/03/31 20:04 [pubmed] PHST- 2025/03/31 04:52 [entrez] PHST- 2025/09/01 00:00 [pmc-release] AID - dmj.2024.0731 [pii] AID - dmj-2024-0731 [pii] AID - 10.4093/dmj.2024.0731 [doi] PST - ppublish SO - Diabetes Metab J. 2025 Sep;49(5):1087-1105. doi: 10.4093/dmj.2024.0731. Epub 2025 Mar 31. PMID- 40159364 OWN - NLM STAT- MEDLINE DCOM- 20250331 LR - 20250515 IS - 1349-3299 (Electronic) IS - 1349-2365 (Linking) VI - 66 IP - 2 DP - 2025 TI - Venous Pressure Cost for Cardiac Index Increases During Exercise in Patients with Fontan Circulation Versus Those with Biventricular Circulation. PG - 271-278 LID - 10.1536/ihj.24-490 [doi] AB - Patients with Fontan circulation (Fontan) have a higher venous pressure (VP) and lower cardiac index (CI) than those with biventricular circulation (BiV). Although the cost to increase VP per unit CI (DeltaVP/DeltaCI) during exercise is expected to be higher in Fontan than in BiV, to our knowledge, no previous study has specifically tested DeltaVP/DeltaCI as the main variable.We included 9 patients with Fontan and 10 with postoperative BiV in this pilot study and assessed their hemodynamics via an ergometer-based exercise test. CI was continuously measured using impedance cardiography.The median age and quartile range values in patients with Fontan (15.0 [13.6, 16.7] years) were significantly higher than those in patients with BiV (12.9 [11.3, 14.3] years, P = 0.028). The DeltaVP/DeltaCI values were significantly higher in the Fontan group than in the BiV group at 25 W (4.5 [4.3, 6.0] versus 1.1 [0.9, 2.6] mmHg/ (L/minute/m(2)), respectively; P = 0.0008) and peak exercise (3.6 [33, 4.5] versus 1.1 [0.9, 1.5] mmHg/ (L/minute/m(2)), respectively; P = 0.0002) irrespective of age. The areas under the curve values of the 2 receiver operating curves (at 25 W and peak exercise time points) were 0.961 and 0.967, respectively. Patients with Fontan exhibited the 3 highest DeltaVP/DeltaCI values at peak exercise had an elevated New York Heart Association functional class (IIm-III) and hemodynamic concerns.Patients with Fontan displayed a higher cost to increase VP per unit CI. DeltaVP/DeltaCI may be a potential circulatory or prognostic marker for these patients and its value should be validated via larger prospective studies. FAU - Takao, Hiroyuki AU - Takao H AD - Department of Pediatric Cardiology, International Medical Center, Saitama Medical University. FAU - Sugiyama, Koki AU - Sugiyama K AD - Department of Pediatrics, Saitama Medical Center, Saitama Medical University. FAU - Kojima, Takuro AU - Kojima T AD - Department of Pediatric Cardiology, International Medical Center, Saitama Medical University. FAU - Iwamoto, Yoichi AU - Iwamoto Y AD - Department of Pediatrics, Saitama Medical Center, Saitama Medical University. FAU - Ishido, Hirotaka AU - Ishido H AD - Department of Pediatrics, Saitama Medical Center, Saitama Medical University. FAU - Masutani, Satoshi AU - Masutani S AD - Department of Pediatric Cardiology, International Medical Center, Saitama Medical University. AD - Department of Pediatrics, Saitama Medical Center, Saitama Medical University. LA - eng PT - Comparative Study PT - Journal Article PL - Japan TA - Int Heart J JT - International heart journal JID - 101244240 SB - IM MH - Humans MH - *Fontan Procedure/methods MH - Female MH - Male MH - Adolescent MH - Pilot Projects MH - Exercise Test/methods MH - Child MH - *Heart Defects, Congenital/surgery/physiopathology MH - Venous Pressure/physiology MH - *Exercise/physiology MH - *Cardiac Output/physiology MH - Hemodynamics/physiology OTO - NOTNLM OT - Cardiac output OT - Central venous pressure OT - Ergometer OT - Peripheral venous pressure OT - Univentricular EDAT- 2025/03/31 20:04 MHDA- 2025/03/31 20:05 CRDT- 2025/03/30 23:03 PHST- 2025/03/31 20:05 [medline] PHST- 2025/03/31 20:04 [pubmed] PHST- 2025/03/30 23:03 [entrez] AID - 10.1536/ihj.24-490 [doi] PST - ppublish SO - Int Heart J. 2025;66(2):271-278. doi: 10.1536/ihj.24-490. PMID- 40158184 OWN - NLM STAT- MEDLINE DCOM- 20250515 LR - 20250515 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Mar 29 TI - Children's physical fitness and cognitive control in China: the moderating role of family support for physical activity. PG - 1198 LID - 10.1186/s12889-025-22397-w [doi] LID - 1198 AB - OBJECTIVE: This study aimed to explore the relationship between physical fitness and cognitive control in Chinese children, with a focus on gender differences and the moderating role of family support for physical activity (FSFPA). METHOD: This study employed a cross-sectional design to assess 148 children aged 12-14 years from Guangzhou. Physical fitness was evaluated using the National Student Physical Fitness Standard, family support for physical activity (FSFPA) was measured with the validated Family Support for Physical Activity Scale, and cognitive control was assessed using the Stroop color-word task, Go/No-Go task, and task-cue paradigm. The statistical analyses included descriptive statistics, correlation analysis, and hierarchical regression analysis to examine the relationships between variables. RESULTS: Gender differences were observed in physical fitness and cognitive control. Girls scored higher in physical fitness and showed better accuracy in interference suppression, with faster reaction times in impulse control. BMI and speed were positively correlated with cognitive flexibility in both genders. For boys, cardiopulmonary endurance positively affected interference suppression, and muscle strength influenced impulse control. BMI and speed were linked to cognitive flexibility. For girls, speed, cardiopulmonary endurance, and muscle strength improved interference suppression, while BMI influenced cognitive flexibility. FSFPA moderated the relationship between physical fitness and cognitive control for both genders. It positively impacted interference suppression and cognitive flexibility for both boys and girls. CONCLUSION: Physical fitness in Chinese children is positively associated with cognitive control, with gender-specific differences in the fitness components influencing cognitive outcomes. FSFPA significantly moderates this relationship, enhancing the positive effects of physical fitness on cognitive control. These findings suggest that promoting physical fitness, particularly through family-based physical activity support, may improve children's cognitive control abilities. CI - (c) 2025. The Author(s). FAU - Zhang, Fengling AU - Zhang F AD - School of Physical Education, South China University of Technology, Guangzhou, China. FAU - Wang, Xiaoqi AU - Wang X AD - The University of Sydney, Sydney, Australia. FAU - Peng, Kefu AU - Peng K AD - School of Physical Education, South China University of Technology, Guangzhou, China. FAU - Xu, Lei AU - Xu L AD - School of Physical Education, South China University of Technology, Guangzhou, China. spxulei@scut.edu.cn. LA - eng GR - QNMS202303/Central University Social Sciences Project of South China University of Technology/ GR - GD23XTY28/Guangdong Provincial Philosophy and Social Sciences Project/ GR - 2017WQNCX001/the Youth Innovative Talent Project of the Department of Education of Guangdong Province (Humanities and Social Sciences)/ PT - Journal Article DEP - 20250329 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - Male MH - Child MH - *Physical Fitness/psychology MH - China MH - Cross-Sectional Studies MH - Adolescent MH - *Cognition/physiology MH - *Exercise/psychology MH - Sex Factors MH - *Social Support MH - Family Support PMC - PMC11954196 OTO - NOTNLM OT - Children OT - Cognitive control OT - FSFPA OT - Physical fitness COIS- Declarations. Ethics approval and consent to participate: Firstly, this study strictly adheres to the Helsinki Declaration, and all methods are implemented by relevant guidelines and regulations. Secondly, this study was approved by the Ethics Committee for Scientific Research of Guangzhou College of Commerce (NO.GCC2023-003). Finally, informed consent was obtained from each participant's legal guardian before participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/03/30 23:02 MHDA- 2025/03/30 23:03 PMCR- 2025/03/29 CRDT- 2025/03/29 23:34 PHST- 2024/11/20 00:00 [received] PHST- 2025/03/19 00:00 [accepted] PHST- 2025/03/30 23:03 [medline] PHST- 2025/03/30 23:02 [pubmed] PHST- 2025/03/29 23:34 [entrez] PHST- 2025/03/29 00:00 [pmc-release] AID - 10.1186/s12889-025-22397-w [pii] AID - 22397 [pii] AID - 10.1186/s12889-025-22397-w [doi] PST - epublish SO - BMC Public Health. 2025 Mar 29;25(1):1198. doi: 10.1186/s12889-025-22397-w. PMID- 40157952 OWN - NLM STAT- MEDLINE DCOM- 20250514 LR - 20250521 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Mar 29 TI - A reference equation for peak oxygen uptake for cycle ergometry in Chinese adult participants. PG - 10876 LID - 10.1038/s41598-025-94207-7 [doi] LID - 10876 AB - Accurately quantifying cardiorespiratory fitness (CRF) through cardiopulmonary exercise testing (CPET) is increasingly important for improving risk assessment and guiding clinical decisions. However, research on V̇O(2)peak reference values and predictive equations for the Chinese population remains limited. This study aimed to establish a V̇O(2)peak predictive equation for Chinese adults. This study analyzed healthy participants who underwent CPET at Peking University Third Hospital (PUTH) from September 1, 2017, to September 1, 2023. Data from September 1, 2017, and August 31, 2021 were used as the derivation cohort, and September 1, 2021, to September 1, 2023 were utilized as an external validation cohort for temporal validation. The derivation cohort underwent backward multivariate regression analysis to generate the V̇O(2)peak prediction equation, which was compared with the widely-used Wasserman, FRIEND and Xiangya equations. The PUTH derivation cohort (N = 4531, mean age: 50.7 years, 18-88 years) and validation cohort (N = 4624, mean age: 46.1 years, 18-89 years) included 48.8 and 48.5% men, respectively. With increasing age, both men and women V̇O(2)peak exhibited a general decline. The predictive equation for V̇O(2)peak was established based on the derivation cohort: V̇O(2)peak (mL.min(-1)) = -24364.9 - 621.3 x Sex (Women = 1, Men = 2) -10.7 x Age + 0.2 x Height(2) (cm) + 6464.7 x Log(BMI) -24997.2 x Log(BSA) +12388.6 x Log(LBM) (adjusted R(2) = 0.624, p < 0.001). It demonstrated higher consistency between measured and predicted results compared to Xiangya, Wasserman, and FRIEND equations. This study presents the PUTH equation, a new V̇O(2)peak prediction equation for Chinese adults. Compared to existing equations, the PUTH equation shows reduced bias and improved accuracy, providing a more reliable tool for assessing CRF and guiding clinical interventions in the Chinese population. CI - (c) 2025. The Author(s). FAU - Wang, Jinan AU - Wang J AD - Department of Cardiology and Institute of Vascular Medicine, National Health Commission, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, No. 49 Huayuanbei Road, Haidian District, Beijing, 100191, China. FAU - Ren, Chuan AU - Ren C AD - Department of Cardiology and Institute of Vascular Medicine, National Health Commission, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, No. 49 Huayuanbei Road, Haidian District, Beijing, 100191, China. FAU - Xu, Shunlin AU - Xu S AD - Department of Cardiology and Institute of Vascular Medicine, National Health Commission, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, No. 49 Huayuanbei Road, Haidian District, Beijing, 100191, China. FAU - Yuan, Yifang AU - Yuan Y AD - Clinical Research Institute, Institute of Advanced Clinical Medicine, Peking University, Beijing, 100191, China. FAU - Song, Yanxin AU - Song Y AD - Department of Cardiology and Institute of Vascular Medicine, National Health Commission, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, No. 49 Huayuanbei Road, Haidian District, Beijing, 100191, China. FAU - Xie, Dingding AU - Xie D AD - Department of Cardiology and Institute of Vascular Medicine, National Health Commission, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, No. 49 Huayuanbei Road, Haidian District, Beijing, 100191, China. FAU - Wang, Kexin AU - Wang K AD - Department of Cardiology and Institute of Vascular Medicine, National Health Commission, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, No. 49 Huayuanbei Road, Haidian District, Beijing, 100191, China. FAU - Yuan, Lei AU - Yuan L AD - Department of Cardiology and Institute of Vascular Medicine, National Health Commission, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, No. 49 Huayuanbei Road, Haidian District, Beijing, 100191, China. FAU - Shen, Tao AU - Shen T AD - Department of Cardiology and Institute of Vascular Medicine, National Health Commission, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, No. 49 Huayuanbei Road, Haidian District, Beijing, 100191, China. FAU - Xu, Ling AU - Xu L AD - Department of Cardiology and Institute of Vascular Medicine, National Health Commission, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, No. 49 Huayuanbei Road, Haidian District, Beijing, 100191, China. FAU - Tang, Yida AU - Tang Y AD - Department of Cardiology and Institute of Vascular Medicine, National Health Commission, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, No. 49 Huayuanbei Road, Haidian District, Beijing, 100191, China. FAU - Gao, Wei AU - Gao W AD - Department of Cardiology and Institute of Vascular Medicine, National Health Commission, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, No. 49 Huayuanbei Road, Haidian District, Beijing, 100191, China. FAU - Zhao, Wei AU - Zhao W AD - Department of Cardiology and Institute of Vascular Medicine, National Health Commission, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, No. 49 Huayuanbei Road, Haidian District, Beijing, 100191, China. beate_vv@126.com. AD - Physical Examination Center of Peking University Third Hospital, Beijing, 100191, China. beate_vv@126.com. LA - eng GR - BYSYZD2021008/Peking University Third Hospital/ GR - 2020YB02/Office of the Central Health Commission/ PT - Journal Article DEP - 20250329 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - Chinese people SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - *Cardiorespiratory Fitness/physiology MH - China MH - *Exercise Test/methods MH - *Oxygen Consumption/physiology MH - Reference Values MH - East Asian People PMC - PMC11954922 OTO - NOTNLM OT - Cardiopulmonary exercise testing OT - Cardiorespiratory fitness OT - Peak oxygen uptake OT - V̇O2peak predictive equation COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/03/30 23:02 MHDA- 2025/03/30 23:03 PMCR- 2025/03/29 CRDT- 2025/03/29 23:16 PHST- 2024/07/26 00:00 [received] PHST- 2025/03/12 00:00 [accepted] PHST- 2025/03/30 23:03 [medline] PHST- 2025/03/30 23:02 [pubmed] PHST- 2025/03/29 23:16 [entrez] PHST- 2025/03/29 00:00 [pmc-release] AID - 10.1038/s41598-025-94207-7 [pii] AID - 94207 [pii] AID - 10.1038/s41598-025-94207-7 [doi] PST - epublish SO - Sci Rep. 2025 Mar 29;15(1):10876. doi: 10.1038/s41598-025-94207-7. PMID- 40156528 OWN - NLM STAT- MEDLINE DCOM- 20250329 LR - 20260422 IS - 1998-3603 (Electronic) IS - 0970-9290 (Linking) VI - 35 IP - 4 DP - 2024 Oct 1 TI - Radiologic Age Validation using Demirjian's 8-Teeth Method - An Institutional Anthropological Study on North-Indian Population. PG - 421-424 LID - 10.4103/ijdr.ijdr_465_23 [doi] AB - INTRODUCTION: Age estimation forms a major part of forensic odontologic investigations and makes use of morphologic, radiographic, histologic, and biochemical methods. While anthropometry, development of sexual characters, and dentition are used when chronological age is unavailable, the data obtained from dentition is also recommended as evidence due to its better accuracy and easy determination of tooth calcification. METHODOLOGY: The study aims to apply the revised 8-teeth method of Demirjian in validating the age of juveniles and very young adults (7-25 years) by using Acharya's India-specific formulas to correlate estimated age with actual age and establish the method's accuracy in the local population. Patients between the age group 7 and 25 requiring Orthopantomograms (OPGs) were taken for the study and assigned a stage based on the 'Tooth development chart'. Gender-specific regression formula was applied to derive the estimated age and compare it with the actual age. RESULTS: Results revealed India-specific regression formula to be more reliable than the modified Demirjian method in correlating the actual and estimated ages. Its accuracy seems to be better only for a narrow age range (14-17 years) within the study group. Better age predictability is seen among females than males in this age group. This method is suitable as an adjunct to other age estimation methods. DISCUSSION: The wide variety and diversity in the Indian population along with regional variations in culture and habitat leads to a significant difference in dental developmental stages. This validates the need for India-weighted scores within different parts of North India to assess its reliability. CI - Copyright (c) 2025 Indian Journal of Dental Research. FAU - Saxena, Susmita AU - Saxena S AD - Department of Oral and Maxillofacial Pathology, ESIC Dental College and Hospital, Rohini, New Delhi, India. FAU - Nithya, S AU - Nithya S AD - Department of Oral and Maxillofacial Pathology, ESIC Dental College and Hospital, Rohini, New Delhi, India. FAU - Kharbanda, Jitin AU - Kharbanda J AD - Department of Oral and Maxillofacial Pathology, ESIC Dental College and Hospital, Rohini, New Delhi, India. FAU - Atri, Mansi AU - Atri M AD - Department of Public Health Dentistry, ESIC Dental College and Hospital, Rohini, New Delhi, India. LA - eng PT - Journal Article PT - Validation Study DEP - 20250329 PL - India TA - Indian J Dent Res JT - Indian journal of dental research : official publication of Indian Society for Dental Research JID - 9202990 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - India MH - Adolescent MH - Male MH - *Radiography, Panoramic MH - Female MH - Child MH - Young Adult MH - Adult MH - Tooth Calcification/physiology MH - *Tooth/diagnostic imaging/growth & development EDAT- 2025/03/29 16:44 MHDA- 2025/03/29 16:45 CRDT- 2025/03/29 09:13 PHST- 2023/05/24 00:00 [received] PHST- 2025/01/17 00:00 [accepted] PHST- 2025/03/29 16:45 [medline] PHST- 2025/03/29 16:44 [pubmed] PHST- 2025/03/29 09:13 [entrez] AID - 01363779-202435040-00013 [pii] AID - 10.4103/ijdr.ijdr_465_23 [doi] PST - ppublish SO - Indian J Dent Res. 2024 Oct 1;35(4):421-424. doi: 10.4103/ijdr.ijdr_465_23. Epub 2025 Mar 29. PMID- 40156065 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250331 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 13 IP - 1 DP - 2025 Mar 28 TI - Development and face validity of the Danish STOB screening tool for early detection of binge eating disorder in children and adolescents. PG - 55 LID - 10.1186/s40337-025-01237-7 [doi] LID - 55 AB - BACKGROUND: Binge Eating Disorder (BED) is prevalent among children and adolescents and is associated with severe psychological and somatic health complications. Early detection and intervention are therefore crucial. This study aimed to develop, pilot test, and validate the STOB screening tool (Screening Tool for the early detection Of BED), designed for use in children and adolescents aged 13-18 in primary care settings using a qualitative face validity approach. Additionally, the study explored the perceived acceptability of a supplementary dialogue tool. METHODS: The development, pilot testing, and validation of the screening tool followed a two-phase qualitative process. In phase one, development and pilot-testing of the 6-item STOB tool was conducted. In phase two, the validation process incorporated a survey and semi-structured interviews, both assessing various aspects of the screening tool, including language complexity, usability, acceptability, and the presence of uncomfortable or intrusive terms. A total of 42 participants, aged 14-18 years (mean age = 16.4 years), were recruited from a community sample for the survey (23 females, 19 males). For the interviews, 10 participants (8 females, 2 males; mean age = 15.7 years) from the community sample were included, resulting in seven individual interviews and one group interview. Additionally, two female participants with BED, aged 16 and 17, were recruited for interviews only. RESULTS: A total of 16.7% of survey respondents met the screening tool threshold for possible BED, and 4.8% of the total sample scored positive on all questions, further increasing the suspicion of BED. Both the survey and interviews indicated that the screening questions were generally well-understood. However, a few linguistic challenges were identified during interviews, prompting minor semantic adjustments to enhance clarity and accessibility. The Interviews revealed age-related differences in language perception and notable differences in content comprehension between participants with and without BED. CONCLUSION: The STOB screening tool demonstrates acceptable face validity and potential for implementation in primary care, particularly when accompanied by the supplementary dialogue tool. This study underscores the importance of evaluating self-report questionnaires in terms of terminology and acceptability within the target population. Further validation is recommended across broader adolescent populations. TRIAL REGISTRATION: Not applicable. CI - (c) 2025. The Author(s). FAU - Maigaard, Sidsel AU - Maigaard S AUID- ORCID: 0009-0005-6537-5051 AD - The Danish National Center for Obesity, Aarhus University Hospital, Palle Juul-Jensens Boulevard 11, entrance A, 8200 Aarhus N, Denmark. FAU - Andreassen, Pernille AU - Andreassen P AUID- ORCID: 0000-0002-5505-3471 AD - The Danish National Center for Obesity, Aarhus University Hospital, Palle Juul-Jensens Boulevard 11, entrance A, 8200 Aarhus N, Denmark. pernilleandreassen@ncfo.dk. FAU - Clausen, Loa AU - Clausen L AUID- ORCID: 0000-0002-4559-8347 AD - Aarhus University Hospital Psychiatry, Aarhus, Denmark. AD - Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. FAU - Bruun, Jens Meldgaard AU - Bruun JM AUID- ORCID: 0000-0001-9937-5467 AD - The Danish National Center for Obesity, Aarhus University Hospital, Palle Juul-Jensens Boulevard 11, entrance A, 8200 Aarhus N, Denmark. AD - Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. AD - Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark. LA - eng GR - 05-0801-580/Sundhedsstyrelsen/ PT - Journal Article DEP - 20250328 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC11951758 OAB - Binge Eating Disorder (BED) occurs across all age groups and can lead to negative health consequences both mentally and physically. Early detection of BED is important so that those affected can receive the help they need. This study presents the development, pilot testing, and validation of the STOB screening tool, designed to help identify BED in children and adolescents in primary care settings. The screening tool, along with a supplementary dialogue tool to help general practitioners discuss binge eating behaviors with younger patients, was tested in adolescents both with and without BED to assess whether the tools' terminology and usability were acceptable within the target population. Overall, the screening and dialogue tools were well received and show a lot of promise for implementation in primary care settings. OABL- eng OTO - NOTNLM OT - Adolescents OT - Binge eating disorder OT - Children OT - Early intervention OT - Eating disorders OT - Face validity OT - Obesity OT - Overweight OT - Screening COIS- Declarations. Ethics approval and consent to participate: This study protocol was approved by the local Committee of Ethics (Region Midtjylland, approval no. 1-10-72-124-22) and was registered in the Central Research Registry of Central Denmark Region (registration no. 783507). Written informed consent for participation in this study was obtained from participants over 15 in accord with Danish regulations. For participants under 15, written parental consent was obtained. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/03/29 16:14 MHDA- 2025/03/29 16:15 PMCR- 2025/03/28 CRDT- 2025/03/29 00:53 PHST- 2024/12/13 00:00 [received] PHST- 2025/03/13 00:00 [accepted] PHST- 2025/03/29 16:15 [medline] PHST- 2025/03/29 16:14 [pubmed] PHST- 2025/03/29 00:53 [entrez] PHST- 2025/03/28 00:00 [pmc-release] AID - 10.1186/s40337-025-01237-7 [pii] AID - 1237 [pii] AID - 10.1186/s40337-025-01237-7 [doi] PST - epublish SO - J Eat Disord. 2025 Mar 28;13(1):55. doi: 10.1186/s40337-025-01237-7. PMID- 40155869 OWN - NLM STAT- MEDLINE DCOM- 20250825 LR - 20260813 IS - 1552-6127 (Electronic) IS - 1090-1981 (Print) IS - 1090-1981 (Linking) VI - 52 IP - 4 DP - 2025 Aug TI - Associations Between Social Support, Social Control, and Stage of Change With Self-Reported and Objectively Assessed Physical Activity in Adult Latino Dyads. PG - 418-427 LID - 10.1177/10901981251322379 [doi] AB - Health behaviors such as physical activity (PA) are socially influenced, such that individuals from shared social networks or living environments may exhibit similar habits. This cross-sectional study examined associations of social support, social control, and family member stage of change with moderate-to-vigorous self-reported and objective PA in dyads of adult Hispanic family members. We used the Godin Leisure-Time Physical Activity Questionnaire to assess self-reported PA and accelerometry for objective PA. Validated scales assessed social support, social control, and stage of change. We performed multivariable multilevel analysis using generalized estimating equations (GEE) to account for within-dyad correlations. We conducted multivariable negative binomial regression for Metabolic Equivalent Task minutes (MET-minutes) (self-reported; N = 429) and accelerometer data (N = 356) and logistic regression for meeting PA guidelines (self-reported; N = 429). Most dyads were spouses (41%) or parents and adult children (32%). Individuals with high family support had 81% higher odds of meeting PA guidelines (1.81 adjusted odds ratio (aOR); 95% confidence interval [CI] = [1.06, 3.09]; p = .030) and 58% higher leisure-time MET-minutes of PA per week (1.58 adjusted incidence rate ratio [aIRR], 95% CI = [1.30, 1.91]; p < .0001) than those with low levels of support. Participants reporting medium-to-high family punishment were 98% higher in odds of meeting PA guidelines (1.98 aOR; 95% CI = [1.09, 3.61]; p = .025) and had 70% higher leisure-time MET-minutes of PA (1.7 aIRR; 95% CI = [1.36, 2.13]; p<.0001) compared with those with low scores. Participants with study partners in action or maintenance stages had significantly higher leisure-time MET-minutes of PA per week (aIRR = 1.45, 95% CI = [1.10, 1.91], p = .009 and aIRR = 1.33, 95% CI = [1.01, 1.76], p = .041, respectively) compared with those with partners in other stages. No statistically significant associations were observed for social control with any measure of PA or between psychosocial measures and accelerometer-assessed PA. Our findings demonstrated that interventions should engage social networks and multimodal forms of PA assessment to optimize behavior change in similar populations. FAU - John, Jemima C AU - John JC AUID- ORCID: 0000-0002-3710-4984 AD - The University of Texas Health Science Center at Houston, Houston, TX, USA. FAU - Lee, MinJae AU - Lee M AUID- ORCID: 0000-0002-4329-506X AD - The University of Texas Southwestern Medical Center, Dallas, TX, USA. FAU - Park, Soo K AU - Park SK AD - The University of Texas Health Science Center at Houston, Houston, TX, USA. FAU - McNeill, Lorna H AU - McNeill LH AD - The University of Texas MD Anderson Cancer Center, Houston, TX, USA. FAU - Hoelscher, Deanna M AU - Hoelscher DM AD - The University of Texas Health Science Center at Houston, Houston, TX, USA. FAU - Schembre, Susan M AU - Schembre SM AD - Georgetown Lombardi Comprehensive Cancer Center, Washington, DC, USA. FAU - Reininger, Belinda M AU - Reininger BM AD - The University of Texas Health Science Center at Houston, Houston, TX, USA. FAU - Strong, Larkin L AU - Strong LL AD - The University of Texas MD Anderson Cancer Center, Houston, TX, USA. LA - eng GR - P30 CA016672/CA/NCI NIH HHS/United States GR - R01 HL128705/HL/NHLBI NIH HHS/United States GR - R56 HL128705/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20250328 PL - United States TA - Health Educ Behav JT - Health education & behavior : the official publication of the Society for Public Health Education JID - 9704962 SB - IM MH - Humans MH - Female MH - Male MH - *Social Support MH - *Exercise/psychology MH - *Hispanic or Latino/psychology/statistics & numerical data MH - Cross-Sectional Studies MH - Self Report MH - Adult MH - Middle Aged MH - Accelerometry MH - *Health Behavior/ethnology MH - *Family/psychology MH - Surveys and Questionnaires MH - Leisure Activities MH - White PMC - PMC13277556 MID - NIHMS2123849 OTO - NOTNLM OT - Latinos OT - binomial regression OT - dyads OT - physical activity OT - social control OT - social support OT - stages of change COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/03/29 16:14 MHDA- 2025/09/08 07:53 PMCR- 2026/06/18 CRDT- 2025/03/29 00:46 PHST- 2025/09/08 07:53 [medline] PHST- 2025/03/29 16:14 [pubmed] PHST- 2025/03/29 00:46 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.1177/10901981251322379 [doi] PST - ppublish SO - Health Educ Behav. 2025 Aug;52(4):418-427. doi: 10.1177/10901981251322379. Epub 2025 Mar 28. PMID- 40155753 OWN - NLM STAT- MEDLINE DCOM- 20250329 LR - 20250515 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Mar 28 TI - Comparison of serum calcium, magnesium, phosphate, alkaline phosphatase, and vitamin D levels in children consuming reverse osmosis, non reverse osmosis, and high fluoride drinking water. PG - 10689 LID - 10.1038/s41598-025-94758-9 [doi] LID - 10689 AB - Water is vital for the human body. Due to concerns over tap water, preference for taste, and convenience, there has been increased consumption of reverse osmosis (RO) water. Various metal ions (e.g., magnesium, calcium, sodium) are essential for human growth and function. Evaluate and compare serum calcium, magnesium, phosphate, alkaline phosphatase, and vitamin D levels in children consuming RO, non-RO, and high-fluoride drinking water. This comparative study included children aged 9-13. Participants were divided into three groups: RO water drinkers, non-RO water drinkers, and those consuming high-fluoride water. A questionnaire gathered socio-demographic, medical, sunlight exposure, and including a validated food frequency questionnaire (FFQ) for nutrient intake. Water samples were analyzed per APHA guidelines for calcium, magnesium, phosphorous, fluoride, and TDS. Urine samples assessed calcium and creatinine, while automated chemistry analyzers measured calcium, phosphorous, and alkaline phosphatase. Vitamin D levels were analyzed using immunoassay. Participants across all age groups were evenly distributed among the three water type groups. Drinking water type significantly correlated with serum and ionic calcium, magnesium, alkaline phosphatase, and serum phosphate levels. Higher 24-h urine calcium and creatinine were found in the high-fluoride group. Regression analysis showed significant associations between drinking water calcium, magnesium, phosphate, TDS, and serum levels after adjusting for age, gender, socioeconomic status, and dietary intake. (serum calcium = beta = 0.006, p < 0.001, serum magnesium = beta = 0.002, p < 0.001,serum phosphate = beta = - 1.260, p = 0.016). Drinking water type impacts serum calcium, magnesium, phosphate, and alkaline phosphatase levels in children. CI - (c) 2025. The Author(s). FAU - Thippeswamy, H M AU - Thippeswamy HM AD - Department of Public Health Dentistry, JSS Dental College and Hospital, JSS Academy Of Higher Education and Research, Mysore, 570015, India. FAU - Shanbhog, Raghavendra AU - Shanbhog R AD - Department of Pediatric Dentistry, JSS Dental College and Hospital, JSS Academy of Higher Education and Research, Mysore, 570015, India. FAU - Kumar, M Nanditha AU - Kumar MN AD - Department of Prosthodontics, JSS Dental College and Hospital, JSS Academy of Higher Education and Research, Mysore, 570015, India. dr.nandithakumarm@jssuni.edu.in. FAU - Prashanth, S N AU - Prashanth SN AD - Department of Pediatrics, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysore, 570015, India. FAU - Smitha, P AU - Smitha P AD - Department of Public Health Dentistry, JSS Dental College and Hospital, JSS Academy Of Higher Education and Research, Mysore, 570015, India. LA - eng GR - NoF.N.5/9/1325/2020 NUT/Indian Council of Medical Research/ PT - Comparative Study PT - Journal Article DEP - 20250328 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - I38ZP9992A (Magnesium) RN - 0 (Drinking Water) RN - EC 3.1.3.1 (Alkaline Phosphatase) RN - Q80VPU408O (Fluorides) RN - SY7Q814VUP (Calcium) RN - 1406-16-2 (Vitamin D) RN - 0 (Phosphates) SB - IM MH - Humans MH - Child MH - *Magnesium/blood MH - *Drinking Water/chemistry/analysis MH - *Alkaline Phosphatase/blood MH - Female MH - Male MH - *Fluorides/analysis MH - Adolescent MH - *Calcium/blood MH - *Vitamin D/blood MH - *Phosphates/blood MH - Osmosis PMC - PMC11953389 OTO - NOTNLM OT - Alkaline phosphatase OT - High fluoride water OT - Magnesium OT - RO water OT - Serum calcium COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/03/29 16:14 MHDA- 2025/03/29 16:15 PMCR- 2025/03/28 CRDT- 2025/03/29 00:33 PHST- 2024/11/04 00:00 [received] PHST- 2025/03/17 00:00 [accepted] PHST- 2025/03/29 16:15 [medline] PHST- 2025/03/29 16:14 [pubmed] PHST- 2025/03/29 00:33 [entrez] PHST- 2025/03/28 00:00 [pmc-release] AID - 10.1038/s41598-025-94758-9 [pii] AID - 94758 [pii] AID - 10.1038/s41598-025-94758-9 [doi] PST - epublish SO - Sci Rep. 2025 Mar 28;15(1):10689. doi: 10.1038/s41598-025-94758-9. PMID- 40154022 OWN - NLM STAT- MEDLINE DCOM- 20250410 LR - 20250410 IS - 1872-8464 (Electronic) IS - 0165-5876 (Linking) VI - 192 DP - 2025 May TI - Risk factors and predictive models for secondary hemorrhage in pediatric coblation tonsillectomy. PG - 112327 LID - S0165-5876(25)00114-4 [pii] LID - 10.1016/j.ijporl.2025.112327 [doi] AB - OBJECTIVE: To identify risk factors for secondary post-tonsillectomy hemorrhage (SPTH) in pediatric patients undergoing Coblation procedures and develop a predictive model to support perioperative management. METHODS: A retrospective analysis was performed on 15,729 children who underwent low-temperature Coblation tonsillectomy at the Children's Hospital, Zhejiang University School of Medicine, between June 2019 and June 2024. Univariate and multivariate analysis were employed to identify factors associated with the occurrence of SPTH. A prediction model was developed based on the identified independent risk factors. To enhance the model's predictive performance and calibration, Weighted Logistic Regression was applied to construct a Nomogram model. The model was validated and evaluated using bootstrap resampling, the consistency index (C-index), Receiver Operating Characteristic (ROC) curve, and Brier Score. RESULTS: Among the 15,729 patients, 9834 (62.52 %) were boys, and 5895 (37.48 %) were girls.The mean age was 6.55 +/- 2.38 years, and the average length of hospitalization was 3.94 +/- 1.51 days. Among the 15,729 children, 235 (1.5 %) experienced SPTH, and 42 (0.3 %) required additional general anesthesia for surgical hemostasis. Univariate analysis identified that gender, age, surgical indication, degree of tonsillar embedding, Body Mass Index (BMI), postoperative diet, and surgeon experience were significantly associated with SPTH (P < 0.05).Multivariate logistic regression analysis revealed that severe tonsillar embedding, junior surgeon, obesity, poor postoperative diet, and age >/=12 years were independent risk factors for SPTH. A Nomogram model was developed based on these independent risk factors. The model was internally validated using bootstrap resampling (1000 iterations). The results showed that the C-index was 0.817, indicating good calibration and stability; ROC curve analysis revealed an Area Under the Curve(AUC)of 0.816, demonstrating strong discriminatory ability; and the Brier Score was 0.0155, indicating minimal error between predicted probabilities and actual outcomes. CONCLUSION: Severe tonsillar embedding, junior surgeon, obesity, poor postoperative diet, and age >/=12 years are independent risk factors for Coblation SPTH in children. The Nomogram model can quickly and efficiently calculate the bleeding rate of SPTH in children, providing valuable guidance for clinical practice. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Xu, Bin AU - Xu B AD - Department of ENT and Head and Neck Surgery, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Bi, Jing AU - Bi J AD - Department of ENT and Head and Neck Surgery, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Fu, Yong AU - Fu Y AD - Department of ENT and Head and Neck Surgery, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Xu, Yilong AU - Xu Y AD - Quanzhou Women's and Children's Hospital, China. FAU - Yu, Lulu AU - Yu L AD - Department of ENT and Head and Neck Surgery, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Han, Yiyuan AU - Han Y AD - Department of ENT and Head and Neck Surgery, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Lin, Xiaoyan AU - Lin X AD - Department of ENT and Head and Neck Surgery, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Hong, Mingyan AU - Hong M AD - Quanzhou Women's and Children's Hospital, China. Electronic address: hmy18120669199@163.com. LA - eng PT - Journal Article DEP - 20250325 PL - Ireland TA - Int J Pediatr Otorhinolaryngol JT - International journal of pediatric otorhinolaryngology JID - 8003603 SB - IM MH - Humans MH - Female MH - *Tonsillectomy/adverse effects/methods MH - Male MH - Risk Factors MH - Retrospective Studies MH - *Postoperative Hemorrhage/etiology/epidemiology MH - Child MH - Nomograms MH - Child, Preschool MH - ROC Curve MH - Logistic Models MH - Infant MH - Risk Assessment MH - Adolescent OTO - NOTNLM OT - Nomogram model OT - Pediatric coblation tonsillectomy OT - Risk factors OT - Secondary post-tonsillectomy hemorrhage COIS- Declaration of Competing interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. During the preparation of this work the author(s) used chatgpt in order to improve the readability and language of the manuscript. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the publication. EDAT- 2025/03/29 16:12 MHDA- 2025/04/11 00:32 CRDT- 2025/03/28 19:05 PHST- 2024/12/15 00:00 [received] PHST- 2025/03/16 00:00 [revised] PHST- 2025/03/24 00:00 [accepted] PHST- 2025/04/11 00:32 [medline] PHST- 2025/03/29 16:12 [pubmed] PHST- 2025/03/28 19:05 [entrez] AID - S0165-5876(25)00114-4 [pii] AID - 10.1016/j.ijporl.2025.112327 [doi] PST - ppublish SO - Int J Pediatr Otorhinolaryngol. 2025 May;192:112327. doi: 10.1016/j.ijporl.2025.112327. Epub 2025 Mar 25. PMID- 40153835 OWN - NLM STAT- MEDLINE DCOM- 20250601 LR - 20250601 IS - 1933-0715 (Electronic) IS - 1933-0707 (Linking) VI - 35 IP - 6 DP - 2025 Jun 1 TI - Healthcare resource utilization for the management of neonatal head shape deformities: a propensity-matched analysis of AI-assisted and conventional approaches. PG - 517-525 LID - 10.3171/2024.12.PEDS24429 [doi] AB - OBJECTIVE: Overuse of radiography studies and underuse of conservative therapies for cranial deformities in neonates is a known inefficiency in pediatric craniofacial healthcare. This study sought to establish whether the introduction of artificial intelligence (AI)-generated craniometrics and craniometric interpretations into craniofacial clinical workflow improved resource utilization patterns in the initial evaluation and management of neonatal cranial deformities. METHODS: A retrospective chart review of pediatric patients referred for head shape concerns between January 2019 and June 2023 was conducted. Patient demographics, final encounter diagnosis, review of an AI analysis, and provider orders were documented. Patients were divided based on whether an AI cranial deformity analysis was documented as reviewed during the index evaluation, then both groups were propensity matched. Rates of index-encounter radiology studies, physical therapy (PT), orthotic therapy, and craniofacial specialist follow-up evaluations were compared using logistic regression and ANOVA analyses. RESULTS: One thousand patient charts were reviewed (663 conventional encounters, 337 AI-assisted encounters). One-to-one propensity matching was performed between these groups. AI models were significantly more likely to be reviewed during telemedicine encounters and advanced practice provider (APP) visits (54.8% telemedicine vs 11.4% in-person, p < 0.0001; 12.3% physician vs 44.4% APP, p < 0.0001). All AI diagnoses of craniosynostosis versus benign deformities were congruent with final diagnoses. AI model review was associated with a significant increase in the use of orthotic therapies for neonatal cranial deformities (31.5% vs 38.6%, p = 0.0132) but not PT or specialist follow-up evaluations. Radiology ordering rates did not correlate with AI-interpreted data review. CONCLUSIONS: As neurosurgeons and pediatricians continue to work to limit neonatal radiation exposure and contain healthcare costs, AI-assisted clinical care could be a cheap and easily scalable diagnostic adjunct for reducing reliance on radiography and encouraging adherence to established clinical guidelines. In practice, however, providers appear to default to preexisting diagnostic biases and underweight AI-generated data and interpretations, ultimately negating any potential advantages offered by AI. AI engineers and specialty leadership should prioritize provider education and user interface optimization to improve future adoption of validated AI diagnostic tools. FAU - Shin, Jimin AU - Shin J AD - 1School of Medicine, University of Connecticut, Farmington. FAU - Caron, Gabrielle AU - Caron G AD - 1School of Medicine, University of Connecticut, Farmington. FAU - Stoltz, Petronella AU - Stoltz P AD - 2Division of Neurosurgery, Connecticut Children's, Hartford; and. FAU - Martin, Jonathan E AU - Martin JE AD - 2Division of Neurosurgery, Connecticut Children's, Hartford; and. AD - 3Department of Surgery, UConn School of Medicine, Hartford, Connecticut. FAU - Hersh, David S AU - Hersh DS AD - 2Division of Neurosurgery, Connecticut Children's, Hartford; and. AD - 3Department of Surgery, UConn School of Medicine, Hartford, Connecticut. FAU - Bookland, Markus J AU - Bookland MJ AD - 2Division of Neurosurgery, Connecticut Children's, Hartford; and. AD - 3Department of Surgery, UConn School of Medicine, Hartford, Connecticut. LA - eng PT - Journal Article DEP - 20250328 PL - United States TA - J Neurosurg Pediatr JT - Journal of neurosurgery. Pediatrics JID - 101463759 SB - IM MH - Humans MH - Retrospective Studies MH - Infant, Newborn MH - Male MH - Female MH - Propensity Score MH - *Artificial Intelligence MH - Cephalometry/methods MH - *Patient Acceptance of Health Care/statistics & numerical data MH - *Health Resources/statistics & numerical data OTO - NOTNLM OT - artificial intelligence OT - craniofacial OT - craniosynostosis OT - healthcare utilization OT - plagiocephaly EDAT- 2025/03/28 18:25 MHDA- 2025/06/02 03:18 CRDT- 2025/03/28 17:53 PHST- 2024/08/26 00:00 [received] PHST- 2024/12/06 00:00 [accepted] PHST- 2025/06/02 03:18 [medline] PHST- 2025/03/28 18:25 [pubmed] PHST- 2025/03/28 17:53 [entrez] AID - 10.3171/2024.12.PEDS24429 [doi] PST - epublish SO - J Neurosurg Pediatr. 2025 Mar 28;35(6):517-525. doi: 10.3171/2024.12.PEDS24429. Print 2025 Jun 1. PMID- 40153787 OWN - NLM STAT- MEDLINE DCOM- 20250515 LR - 20260722 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 9 DP - 2025 Mar 28 TI - User Experience With a Personalized mHealth Service for Physical Activity Promotion in University Students: Mixed Methods Study. PG - e64384 LID - 10.2196/64384 [doi] LID - e64384 AB - BACKGROUND: Regular physical activity (PA) is known to offer substantial health benefits, including improved physical fitness, reduced risk of disease, enhanced psychological well-being, and better cognitive performance. Despite these benefits, many university students fail to meet recommended PA levels, risking long-term health consequences. OBJECTIVE: This study evaluated the user experience (UX) of futur.move, a digital intervention aimed at promoting PA among university students. The service delivers personalized, evidence-based content to foster sustained engagement in PA. METHODS: A mixed methods approach was used to evaluate the prototype of futur.move. UX assessments included on-site and online user tests, standardized questionnaires, and online focus groups. A total of 142 university students participated, with 23 joining additional focus groups. Each participant tested the service for 30 minutes. Quantitative data were collected using the User Experience Questionnaire and analyzed descriptively, followed by correlation analysis with variables such as PA level, age, gender, and experience with PA apps. Qualitative insights were gathered from transcribed focus group discussions and analyzed using content-structuring, qualitative content analysis. Quantitative findings were cross-validated with qualitative data. RESULTS: The UX received positive ratings across 4 User Experience Questionnaire scales (range -3 to +3; higher numbers indicate positive UX): attractiveness (median 1.67, IQR 1.04-2.17), perspicuity (median 1.5, IQR 0.5-2), stimulation (median 1.5, IQR 1-2), and novelty (median 1.25, IQR 0.5-2). Weak correlations were found between adherence to World Health Organization guidelines for PA and the perspicuity subscale (eta=0.232, P=.04), and between age and the perspicuity (Kendall taub=0.132, P=.03) and stimulation subscales (Kendall taub=0.144, P=.02), and a moderate correlation was found between gender and the novelty subscale (eta=0.363, P=.004). Critical feedback from focus group discussions highlighted issues with manual data entry. Qualitative findings aligned with the quantitative results, emphasizing students' appreciation for the personalized, diverse content and social networking features of futur.move. CONCLUSIONS: futur.move demonstrates favorable UX and aligns with student needs, particularly through its personalized content and social features. Improvements should focus on reducing manual data entry and enhancing feature clarity, particularly for the features "your condition" and "goal setting." While correlations between UX ratings and demographic variables were weak to moderate, they warrant further investigation to better address the diverse target audience. The feedback from the students serves as a basis for further adapting the service to their needs and expectations. Future work will involve coding an advanced prototype and conducting a longitudinal study to assess its impact on PA behavior and sustained engagement. CI - (c)Silke Wittmar, Tom Frankenstein, Vincent Timm, Peter Frei, Nicolas Kurpiers, Stefan Wolwer, Axel Georg Meender Schafer. Originally published in JMIR Formative Research (https://formative.jmir.org), 28.03.2025. FAU - Wittmar, Silke AU - Wittmar S AUID- ORCID: 0000-0003-0886-6872 AD - Faculty of Social Work and Health, HAWK University of Applied Sciences and Arts Hildesheim/Holzminden/Gottingen, Hildesheim, Germany. FAU - Frankenstein, Tom AU - Frankenstein T AUID- ORCID: 0009-0002-8990-8287 AD - Faculty of Social Work and Health, HAWK University of Applied Sciences and Arts Hildesheim/Holzminden/Gottingen, Hildesheim, Germany. FAU - Timm, Vincent AU - Timm V AUID- ORCID: 0009-0005-2451-9397 AD - Faculty of Design, HAWK University of Applied Sciences and Arts Hildesheim/Holzminden/Gottingen, Hildesheim, Germany. FAU - Frei, Peter AU - Frei P AUID- ORCID: 0009-0004-8958-8548 AD - Institute for Sport Science, University of Hildesheim, Hildesheim, Germany. FAU - Kurpiers, Nicolas AU - Kurpiers N AUID- ORCID: 0000-0002-3622-5282 AD - Institute for Sport Science, University of Hildesheim, Hildesheim, Germany. FAU - Wolwer, Stefan AU - Wolwer S AUID- ORCID: 0009-0001-1337-9254 AD - Faculty of Design, HAWK University of Applied Sciences and Arts Hildesheim/Holzminden/Gottingen, Hildesheim, Germany. FAU - Schafer, Axel Georg Meender AU - Schafer AGM AUID- ORCID: 0000-0003-4222-1605 AD - Faculty of Social Work and Health, HAWK University of Applied Sciences and Arts Hildesheim/Holzminden/Gottingen, Hildesheim, Germany. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250328 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - Female MH - Male MH - *Students/psychology/statistics & numerical data MH - Universities MH - *Exercise/psychology MH - Young Adult MH - Focus Groups MH - *Telemedicine MH - Adult MH - Surveys and Questionnaires MH - *Health Promotion/methods MH - Mobile Applications MH - Adolescent MH - Qualitative Research PMC - PMC11992504 OTO - NOTNLM OT - college OT - digital intervention OT - engagement OT - exercise OT - health promotion OT - mHealth OT - mixed methods OT - mobile health OT - mobile phone OT - physical activity OT - physical fitness OT - promote OT - smartphone app OT - student OT - undergraduate OT - university student OT - usability testing OT - user OT - user experience COIS- Conflicts of Interest: None declared. EDAT- 2025/03/28 18:25 MHDA- 2025/03/28 18:26 PMCR- 2025/03/28 CRDT- 2025/03/28 16:53 PHST- 2024/07/17 00:00 [received] PHST- 2025/01/19 00:00 [accepted] PHST- 2025/01/14 00:00 [revised] PHST- 2025/03/28 18:26 [medline] PHST- 2025/03/28 18:25 [pubmed] PHST- 2025/03/28 16:53 [entrez] PHST- 2025/03/28 00:00 [pmc-release] AID - v9i1e64384 [pii] AID - 10.2196/64384 [doi] PST - epublish SO - JMIR Form Res. 2025 Mar 28;9:e64384. doi: 10.2196/64384. PMID- 40150959 OWN - NLM STAT- MEDLINE DCOM- 20250503 LR - 20250604 IS - 1469-0705 (Electronic) IS - 0960-7692 (Linking) VI - 65 IP - 5 DP - 2025 May TI - Association of magnetic resonance imaging-derived maternal and fetal parameters with shoulder dystocia: matched case-control study. PG - 604-612 LID - 10.1002/uog.29210 [doi] AB - OBJECTIVE: To assess the association of fetal body measurements and maternal pelvic measurements obtained using magnetic resonance imaging (MRI) with the incidence of shoulder dystocia. METHODS: This was a retrospective, single-center, case-control study conducted between January 2015 and December 2022. Patients whose delivery was complicated by shoulder dystocia and who underwent fetal MRI in the third trimester were included in the case group. Patients without shoulder dystocia who were delivered normally and who also underwent fetal MRI in the third trimester were included in the control group. Cases of multiple pregnancy, planned or emergency Cesarean delivery, fetal malformation or those with incomplete MRI examination were excluded. The case group was matched with the control group in a 1:2 ratio according to maternal age, maternal body mass index, gestational diabetes mellitus, diabetes mellitus Type 1 or 2, gestational age at MRI examination, gestational age at birth and birth weight. Shoulder dystocia was defined as per the Royal College of Obstetricians and Gynecologists and significant shoulder dystocia was defined as shoulder dystocia that was not resolved by the McRoberts' maneuver or suprapubic pressure. The following fetal and maternal measurements were quantified on MRI in both groups by two readers (one experienced and one inexperienced physician) who were blinded to the obstetric outcomes: fetal body volume (FBV), shoulder skin-to-skin distance, interhumeral distance, biparietal diameter (BPD), head circumference, obstetric conjugate (OC), sagittal outlet diameter (SOD), coccygeal pelvic outlet (CPO) and maximal transverse diameter (MTD). A stepwise backward logistic regression that included all measurements was performed. The inter-rater reliability of the measurements was estimated using interclass correlation coefficient (ICC). Statistical significance was set at P < 0.05. RESULTS: Among the 1843 patients included in the study, there were 63 (3.4%) cases of shoulder dystocia. After matching, the case group comprised 36 patients and the control group comprised 72 patients. Patients who had shoulder dystocia, compared to those without, had higher FBV (P = 0.023), higher shoulder skin-to-skin distance (P = 0.003), lower OC (P = 0.021), lower SOD (P = 0.004), lower CPO (P = 0.045) and lower MTD (P = 0.001) in comparison with those without. The logistic regression model showed that FBV, shoulder skin-to-skin distance, BPD, SOD and MTD were independent predictors of shoulder dystocia. The measurements of interest had moderate to excellent reliability when repeated by an inexperienced reader. In those who had non-significant shoulder dystocia, only shoulder skin-to-skin distance was significantly greater and OC was significantly lower in comparison with the control group, whereas in those who had significant shoulder dystocia, only SOD and MTD were significantly lower in comparison with the control group. CONCLUSIONS: MRI-derived fetal size, fetal shoulder measurements and maternal pelvimetry are associated with shoulder dystocia. Future studies could incorporate these measurements into a reliable predictive model for shoulder dystocia. (c) 2025 International Society of Ultrasound in Obstetrics and Gynecology. CI - (c) 2025 International Society of Ultrasound in Obstetrics and Gynecology. FAU - Badr, D A AU - Badr DA AUID- ORCID: 0000-0001-5251-6023 AD - Department of Obstetrics and Gynecology, University Hospital Brugmann, Universite Libre de Bruxelles, Brussels, Belgium. FAU - Abi-Khalil, F AU - Abi-Khalil F AD - Department of Obstetrics and Gynecology, University Hospital Brugmann, Universite Libre de Bruxelles, Brussels, Belgium. FAU - Kadji, C AU - Kadji C AD - Department of Obstetrics and Gynecology, University Hospital Brugmann, Universite Libre de Bruxelles, Brussels, Belgium. FAU - Marroun, N AU - Marroun N AD - Department of Radiology, University Hospital Brugmann, Universite Libre de Bruxelles, Vrije Universiteit Brussel, Brussels, Belgium. FAU - Carlin, A AU - Carlin A AD - Department of Obstetrics and Gynecology, University Hospital Brugmann, Universite Libre de Bruxelles, Brussels, Belgium. FAU - Cannie, M M AU - Cannie MM AD - Department of Radiology, University Hospital Brugmann, Universite Libre de Bruxelles, Vrije Universiteit Brussel, Brussels, Belgium. AD - Department of Radiology, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium. FAU - Jani, J C AU - Jani JC AUID- ORCID: 0000-0003-2252-342X AD - Department of Obstetrics and Gynecology, University Hospital Brugmann, Universite Libre de Bruxelles, Vrije Universiteit Brussel, Brussels, Belgium. LA - eng PT - Journal Article DEP - 20250327 PL - England TA - Ultrasound Obstet Gynecol JT - Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology JID - 9108340 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Case-Control Studies MH - *Shoulder Dystocia/diagnostic imaging/epidemiology/etiology MH - *Magnetic Resonance Imaging/methods MH - Retrospective Studies MH - Adult MH - *Fetus/diagnostic imaging MH - Pregnancy Trimester, Third MH - Gestational Age MH - *Pelvis/diagnostic imaging/embryology MH - Infant, Newborn MH - *Dystocia/diagnostic imaging OTO - NOTNLM OT - PREMACRO study OT - birth weight OT - magnetic resonance imaging OT - pelvimetry OT - shoulder dystocia OT - shoulder width EDAT- 2025/03/28 06:24 MHDA- 2025/05/03 22:26 CRDT- 2025/03/28 02:43 PHST- 2025/01/31 00:00 [revised] PHST- 2024/06/03 00:00 [received] PHST- 2025/02/11 00:00 [accepted] PHST- 2025/05/03 22:26 [medline] PHST- 2025/03/28 06:24 [pubmed] PHST- 2025/03/28 02:43 [entrez] AID - 10.1002/uog.29210 [doi] PST - ppublish SO - Ultrasound Obstet Gynecol. 2025 May;65(5):604-612. doi: 10.1002/uog.29210. Epub 2025 Mar 27. PMID- 40150591 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250330 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 3 DP - 2025 Feb 28 TI - Exploring Visceral Fat as a Screening Marker for Cardiometabolic Risk in Children and Adolescents. LID - 10.3390/children12030308 [doi] LID - 308 AB - Objective: To establish and validate age- and sex-specific visceral fat area (VFA) cutoff values for the effective identification of cardiometabolic risk (CMR) in children and adolescents. Methods: A cross-sectional study involving 8133 participants was conducted to derive age- and sex-specific VFA cutoffs, which were validated in a longitudinal cohort comprising 10,805 individuals. The predictive performance of the derived VFA cutoffs for CMR was evaluated using the area under the receiver operating characteristic curve (AUC). Additionally, logistic regression models were utilized to calculate the relative risk (RR) of CMR associated with elevated VFA levels. Results: The 75th percentile of the VFA was identified as the optimal cutoff for screening for hypertension, hyperglycemia, dyslipidemia, and CMR clustering in boys. In girls, the 75th percentile was optimal for screening hypertension, dyslipidemia, and CMR clustering, while the 80th percentile proved best for hyperglycemia. No significant difference in predicative performance was observed between the optimal and simplified VFA cutoffs. Longitudinal validation demonstrated that individuals exceeding the VFA cutoff had a significantly higher risk for CMR, with RRs ranging from 1.33 to 3.89 (all p < 0.001) for boys and from 1.63 to 3.16 (all p < 0.001) for girls. Notably, normal-weight boys with VFA above the cutoff had a significantly higher CMR risk compared to their peers in other weight status categories. Conclusions: Both the optimal and simplified VFA cutoffs are robust tools for screening CMR in Chinese children and adolescents, with significant implications for early intervention strategies. FAU - Wang, Xia AU - Wang X AD - Center for Non-Communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100035, China. FAU - Cheng, Hong AU - Cheng H AD - Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100035, China. FAU - Xiong, Jingfan AU - Xiong J AD - Department of Child and Adolescent Chronic Disease Prevention and Control, Shenzhen Center for Chronic Disease Control, Shenzhen 518000, China. FAU - Liu, Junting AU - Liu J AD - Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100035, China. FAU - Dong, Hongbo AU - Dong H AUID- ORCID: 0000-0002-2225-3274 AD - Center for Non-Communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100035, China. FAU - Fu, Liwan AU - Fu L AUID- ORCID: 0000-0002-7851-6379 AD - Center for Non-Communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100035, China. FAU - Xie, Xiangjun AU - Xie X AD - Center for Non-Communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100035, China. FAU - Shan, Xinying AU - Shan X AD - Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100035, China. FAU - Zhao, Xiaoyuan AU - Zhao X AD - Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100035, China. FAU - Yan, Yinkun AU - Yan Y AD - Center for Non-Communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100035, China. FAU - Xiao, Pei AU - Xiao P AD - Center for Non-Communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100035, China. FAU - Mi, Jie AU - Mi J AD - Center for Non-Communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100035, China. LA - eng PT - Journal Article DEP - 20250228 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC11941014 OTO - NOTNLM OT - adolescents OT - cardiometabolic risk OT - children OT - cutoffs OT - obesity OT - visceral fat area COIS- The authors declare no conflicts of interest. The sponsors had no role in the design, execution, interpretation, or writing of the study. EDAT- 2025/03/28 06:25 MHDA- 2025/03/28 06:26 PMCR- 2025/02/28 CRDT- 2025/03/28 01:11 PHST- 2025/02/01 00:00 [received] PHST- 2025/02/19 00:00 [revised] PHST- 2025/02/22 00:00 [accepted] PHST- 2025/03/28 06:26 [medline] PHST- 2025/03/28 06:25 [pubmed] PHST- 2025/03/28 01:11 [entrez] PHST- 2025/02/28 00:00 [pmc-release] AID - children12030308 [pii] AID - children-12-00308 [pii] AID - 10.3390/children12030308 [doi] PST - epublish SO - Children (Basel). 2025 Feb 28;12(3):308. doi: 10.3390/children12030308. PMID- 40148865 OWN - NLM STAT- MEDLINE DCOM- 20250514 LR - 20250514 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 25 IP - 1 DP - 2025 Mar 27 TI - Eating behaviors, oral health care knowledge, and oral hygiene practices among residents in Fujian province, China: a cross-sectional study. PG - 446 LID - 10.1186/s12903-025-05747-3 [doi] LID - 446 AB - BACKGROUND: There is little literature that focuses on eating behaviors, oral health care knowledge and oral hygiene habits at the same time. People's oral health is affected by a variety of factors. This study investigated the eating behaviors, oral health care knowledge, and oral hygiene practices among residents of Fujian province, China, with different gender, age, and educational attainment. METHODS: A self-administered questionnaire was designed and distributed through the online questionnaire platform, Questionnaire Star. After excluding unqualified responses (due to excessively short completion time, conflicting answers, etc.), an Excel database was constructed. Frequency counts (composition ratio) were used to characterize data distribution, and the chi-square test was used to compare self-reported oral health, eating behaviors, oral health care knowledge, and oral hygiene practices across different age, gender, and educational attainment of respondents. Data were analyzed using IBM SPSS (version 26.0), and differences were considered statistically significant at P < 0.05. RESULTS: A total of 10,480 individuals completed the online questionnaire, with 8,254 questionnaires deemed valid, yielding a validity rate of 78.76%. Significant differences were observed in various aspects of eating behaviors among respondents of different age, gender, and educational attainment (P < 0.001), except for the consumption of fruit juice and hard foods. There was a significant difference in self-reported oral health status among respondents by age and education (P /= 18 and < 40 years, >/= 37 weeks gestation, at low risk of surgical site infection (SSI) and recruited from a single tertiary centre. We reported proportions of women eligible and consenting; adherence to perioperative infection prevention; blinding adequacy of staff using Bang's blinding index; SSI surveillance and diagnosis according to the Centre for Disease Control definitions and patient reported outcome measures using validated questionnaires up to 90 days. RESULTS: We screened 1651 women, with 1245 (75%) ineligible based on body mass index or presence of diabetes. Of 287 eligible women, 30 were randomized (11%) with 15 in each group. Reasons for non-participation included "wanting antibiotics" (68, 27%), "no reason" (62, 25%) and lack of research staff (33, 13%). Compliance with perioperative infection prevention occurred in 5 of 7 steps. Spontaneous placental separation occurred in 25 (83%) and Comfeel dressing in 29 (97%). Blinding was adequate for all staff groups. SSI surveillance occurred in 156 of 210 (74%) timepoints. SSI occurred in two patients who received pre-incisional cefazolin and were successfully treated as outpatients. Patient reported outcome questionnaires were completed at 136 of 180 (76%) timepoints. There was no difference in maternal health-related quality of life between the groups. CONCLUSIONS: Feasibility was impacted by the high-risk population and patient desire for antibiotics. Adherence to perioperative infection prevention practices were high but incomplete. These study processes could be effectively applied in a larger population, targeting low risk maternity patients. TRIAL REGISTRATION: Prospectively registered 4/12/2019 with the Australian New Zealand Clinical Trials Registry (ACTRN12619001705178). CI - (c) 2025. The Author(s). FAU - Eley, Victoria A AU - Eley VA AD - Department of Anaesthesia and Perioperative Medicine, The Royal Brisbane and Women's Hospital, Butterfield St, Herston, Brisbane, 4006, Queensland, Australia. v.eley@uq.edu.au. AD - Medical School, Faculty of Medicine, The University of Queensland, St Lucia 4067, Brisbane, QLD, Australia. v.eley@uq.edu.au. FAU - Navarro, Severine AU - Navarro S AD - Mucosal Immunology, QIMR Berghofer Medical Research Institute, Herston, Brisbane, 4006, Australia. AD - Centre for Childhood Nutrition Research, Queensland University of Technology, Brisbane, Australia. FAU - Martin, Elizabeth AU - Martin E AD - Wesley Research Institute, Auchenflower, Queensland, 4066, Australia. AD - Mater Research Institute, The University of Queensland, South Brisbane 4101, Brisbane, QLD, Australia. FAU - Amoako, Akwasi AU - Amoako A AD - Medical School, Faculty of Medicine, The University of Queensland, St Lucia 4067, Brisbane, QLD, Australia. AD - Women's and Newborns Services, The Royal Brisbane and Women's Hospital, Butterfield St, Herston, QLD, 4006, Australia. FAU - Hartel, Gunter AU - Hartel G AD - Statistics Unit, QIMR Berghofer Medical Research Institute, Herston, Brisbane, 4006, Australia. AD - School of Public Health, The University of Queensland, Brisbane, QLD, Australia. FAU - Woods, Christine AU - Woods C AD - Department of Anaesthesia and Perioperative Medicine, The Royal Brisbane and Women's Hospital, Butterfield St, Herston, Brisbane, 4006, Queensland, Australia. AD - Medical School, Faculty of Medicine, The University of Queensland, St Lucia 4067, Brisbane, QLD, Australia. FAU - Lu, Yan AU - Lu Y AD - Mucosal Immunology, QIMR Berghofer Medical Research Institute, Herston, Brisbane, 4006, Australia. AD - Centre for Childhood Nutrition Research, Queensland University of Technology, Brisbane, Australia. FAU - Lipman, Jeffrey AU - Lipman J AD - Medical School, Faculty of Medicine, The University of Queensland, St Lucia 4067, Brisbane, QLD, Australia. AD - Jamieson Trauma Institute, The University of Queensland, St Lucia 4067, Brisbane, QLD, Australia. AD - Nimes University Hospital, University of Montpellier, Nimes, France. FAU - Roberts, Jason AU - Roberts J AD - Centre for Clinical Research, Faculty of Medicine, University of Queensland, The University of Queensland, Brisbane, Australia. AD - Herston Infectious Diseases Institute (HeIDI), Metro North Health, Brisbane, 4006, Australia. FAU - Tang, Mimi AU - Tang M AD - Allergy Immunology, Murdoch Children's Research Institute, Parkville, VIC, 3052, Australia. AD - Department of Paediatrics, The University of Melbourne, Parkville, VIC, 3052, Australia. FAU - Callaway, Leonie AU - Callaway L AD - Medical School, Faculty of Medicine, The University of Queensland, St Lucia 4067, Brisbane, QLD, Australia. AD - Women's and Newborns Services, The Royal Brisbane and Women's Hospital, Butterfield St, Herston, QLD, 4006, Australia. LA - eng GR - CRG-267-2021/Metro North Hospital and Health Service/ GR - CR0062020/Children's Hospital Foundation/ GR - RCP10317/Children's Hospital Foundation/ GR - Research Grant/Ferring Pharmaceuticals/ GR - Co-funding/University of Queensland/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20250326 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 RN - IHS69L0Y4T (Cefazolin) RN - 0 (Anti-Bacterial Agents) SB - IM MH - Humans MH - Female MH - *Cefazolin/therapeutic use/administration & dosage MH - *Antibiotic Prophylaxis/methods MH - *Surgical Wound Infection/prevention & control MH - *Cesarean Section/adverse effects/methods MH - Pregnancy MH - Adult MH - *Anti-Bacterial Agents/therapeutic use/administration & dosage MH - Feasibility Studies MH - Prospective Studies PMC - PMC11938549 OTO - NOTNLM OT - Allergy OT - Antibiotics OT - Atopy OT - Cesarean delivery OT - Surgical prophylaxis OT - Surgical site infection OT - Wound infection COIS- Declarations. Ethics approval and consent to participate: Ethics approval was granted by the Human Research Ethics Committee of the Royal Brisbane and Women's Hospital (HREC/2020/QRBW/58840, 17/2/2020). Written informed consent was obtained from all participants. The project was conducted in compliance with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/03/27 06:29 MHDA- 2025/03/27 06:30 PMCR- 2025/03/26 CRDT- 2025/03/27 00:56 PHST- 2024/02/02 00:00 [received] PHST- 2025/03/17 00:00 [accepted] PHST- 2025/03/27 06:30 [medline] PHST- 2025/03/27 06:29 [pubmed] PHST- 2025/03/27 00:56 [entrez] PHST- 2025/03/26 00:00 [pmc-release] AID - 10.1186/s12884-025-07484-5 [pii] AID - 7484 [pii] AID - 10.1186/s12884-025-07484-5 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2025 Mar 26;25(1):353. doi: 10.1186/s12884-025-07484-5. PMID- 40140956 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250328 IS - 2055-0928 (Electronic) IS - 2055-0928 (Linking) VI - 11 IP - 1 DP - 2025 Mar 26 TI - A qualitative study to explore mother's experiences of a family MUAC project in two provinces in South Africa. PG - 61 LID - 10.1186/s40795-025-01003-7 [doi] LID - 61 AB - BACKGROUND: In South Africa, severe acute malnutrition remains a significant cause of child mortality. Measuring mid-upper arm circumference (MUAC) is a simple, cost-effective approach to identify malnutrition in communities. The Family MUAC intervention supported community health workers (CHWs) to mentor mothers and child caregivers to measure MUAC, record their findings and access nutrition information from the child's Road-to-Health-Book. Family MUAC was implemented in seven sites in two provinces in South Africa: Gauteng and KwaZulu-Natal. This study aimed to explore mother/caregiver's perceptions and experiences of participating in Family MUAC. METHODS: Focus group discussions (FGDs) were conducted with mothers purposively selected by CHWs based on their active participation in Family MUAC. Trained qualitative researchers conducted one FGD at each participating site. Coding reliability thematic analysis with topic summaries was employed to analyse the data using Nvivo v12. RESULTS: Seven FGDs were conducted with a total of 59 participants. Key themes identified were mother's perceptions of the CHW's role, experiences of implementing Family MUAC activities, and perceptions of the broader effect on maternal empowerment and child health. Mothers appreciated the support from CHWs who were perceived as patient and caring, taking time to develop mother's skills and answer questions. CHWs provided ongoing care, encouraged participation and understood the mother's home situation. Mothers experienced group learning positively, and helped each other learn about MUAC measurements. Most mothers experienced measuring MUAC as challenging initially, needing support from CHWs to gain confidence to measure and record findings. Participating in Family MUAC empowered mothers in caring for their child, and improved their relationships with CHWs. Mothers compared support from CHWs to care received at the clinic, saying clinic visits were costly and time-consuming and nurses frequently did not explain their findings. Mothers reported feeling more confident to ask questions during clinic visits after participating in family MUAC. CONCLUSIONS: Using CHWs to support mothers measuring MUAC in households was acceptable and feasible. CHWs provided ongoing good quality care, relevant advice and support, and empowered mothers. Family MUAC had wide ranging benefits for building relationships and peer support in communities and strengthened mothers perceived role in the care of her child. CI - (c) 2025. The Author(s). FAU - Horwood, C AU - Horwood C AD - Centre for Rural Health, University of KwaZulu-Natal, Durban, South Africa. horwoodc@ukzn.ac.za. FAU - Luthuli, S AU - Luthuli S AD - Centre for Rural Health, University of KwaZulu-Natal, Durban, South Africa. FAU - Haskins, L AU - Haskins L AD - Centre for Rural Health, University of KwaZulu-Natal, Durban, South Africa. FAU - Mapumulo, S AU - Mapumulo S AD - Centre for Rural Health, University of KwaZulu-Natal, Durban, South Africa. FAU - Kubeka, Z AU - Kubeka Z AD - Child Youth and School Health: National Department of Health, Pretoria, South Africa. FAU - Tshitaudzi, G AU - Tshitaudzi G AD - UNICEF South Africa, Pretoria, Gauteng, South Africa. LA - eng PT - Journal Article DEP - 20250326 PL - England TA - BMC Nutr JT - BMC nutrition JID - 101672434 PMC - PMC11938593 OTO - NOTNLM OT - Africa OT - Child health OT - Children OT - Community health workers OT - Community-based intervention OT - Malnutrition OT - Mid upper arm circumference OT - Severe acute malnutrition OT - South Africa COIS- Declarations. Ethics approval and consent to participate: The study was carried out according to the guidelines and regulations laid down in the declaration of Helsinki. Ethical approval was obtained from the Biomedical Research Ethics Committee (BREC/00003893/2022) at the University of KwaZulu-Natal, and permission was obtained from the KwaZulu-Natal Department of Health (KZ_202203_30) and Gauteng Department of Health (GP_202203_057). Individual approval was obtained from ethics committees in the three districts in Gauteng and letters of support were obtained from the two districts in KZN. All participating mothers and primary child carers provided written informed consent to participate. Consent forms were prepared in isiZulu, Setswana and English. To ensure participants' anonymity participants were allocated a study number and no names or identifying information were recorded on the database. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/03/27 06:28 MHDA- 2025/03/27 06:29 PMCR- 2025/03/26 CRDT- 2025/03/27 00:55 PHST- 2024/09/10 00:00 [received] PHST- 2025/01/14 00:00 [accepted] PHST- 2025/03/27 06:29 [medline] PHST- 2025/03/27 06:28 [pubmed] PHST- 2025/03/27 00:55 [entrez] PHST- 2025/03/26 00:00 [pmc-release] AID - 10.1186/s40795-025-01003-7 [pii] AID - 1003 [pii] AID - 10.1186/s40795-025-01003-7 [doi] PST - epublish SO - BMC Nutr. 2025 Mar 26;11(1):61. doi: 10.1186/s40795-025-01003-7. PMID- 40139181 OWN - NLM STAT- MEDLINE DCOM- 20251013 LR - 20251013 IS - 1662-4033 (Electronic) IS - 1662-4025 (Print) IS - 1662-4025 (Linking) VI - 18 IP - 4 DP - 2025 TI - Development and Validation of a Brief Form of the Weight Control/Blame Subscale of the Antifat Attitudes Test. PG - 364-374 LID - 10.1159/000545380 [doi] AB -

Introduction: The Weight Control/Blame (WCB) subscale of the Antifat Attitudes Test (AFAT) measures weight stigma, particularly beliefs linking obesity to personal responsibility, which contributes to discrimination and negative psychological, often reinforced by political ideologies and authoritarian attitudes. This study sought to (1) develop and validate an economic version of the WCB subscale and (2) evaluate associations between weight stigmatizing attitudes, authoritarian beliefs, sexist attitudes, and conspiracy mentality. METHODS: A four-item short form of the WCB subscale (WCB-4) was developed using a representative sample of the German population (N = 1,000) and validated on a second sample (N = 2,524). We assessed psychometric properties, convergent, and divergent validity. RESULTS: The four-item solution demonstrated good internal consistency (omega = 0.807) and favorable confirmatory factor analysis results. Weight stigma positively correlated with authoritarian and sexist beliefs, and negatively with depression, anxiety, and body mass index. CONCLUSION: The WCB-4 is a reliable and valid tool for assessing weight stigma in epidemiological research. It highlighted positive associations with authoritarian beliefs and sexist attitudes, reflecting an interconnected system of biases against marginalized groups. Though a minor correlation was found between conspiracy mentality and authoritarian beliefs, no significant link emerged between conspiracy mentality and weight stigma.

. CI - (c) 2025 The Author(s). Published by S. Karger AG, Basel. FAU - Petersen, Julia AU - Petersen J FAU - Petersen, Julia AU - Petersen J AD - Integrated Research and Treatment Center Adiposity Diseases, Behavioral Medicine Research Unit, Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Leipzig, Leipzig, Germany. AD - Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany. FAU - Schmalbach, Bjarne AU - Schmalbach B AD - Department of Medical Psychology and Medical Sociology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany. FAU - Brahler, Elmar AU - Brahler E AD - Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany. AD - Department of Medical Psychology and Medical Sociology, Medical Faculty, University of Leipzig, Leipzig, Germany. FAU - Decker, Oliver AU - Decker O AD - Else-Frenkel-Brunswik Insitute for Democracy Research in Saxony, University of Leipzig, Leipzig, Germany. AD - Sigmund-Freud University Berlin, Berlin, Germany. FAU - Hilbert, Anja AU - Hilbert A AD - Integrated Research and Treatment Center Adiposity Diseases, Behavioral Medicine Research Unit, Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Leipzig, Leipzig, Germany. LA - eng PT - Journal Article PT - Validation Study DEP - 20250326 PL - Switzerland TA - Obes Facts JT - Obesity facts JID - 101469429 SB - IM MH - Humans MH - Female MH - Male MH - Adult MH - Middle Aged MH - *Social Stigma MH - *Obesity/psychology MH - Psychometrics MH - Germany MH - Young Adult MH - Surveys and Questionnaires MH - Reproducibility of Results MH - Aged MH - Adolescent MH - Sexism/psychology MH - Authoritarianism MH - Body Weight MH - Body Mass Index PMC - PMC12052364 OTO - NOTNLM OT - Antifat attitudes test OT - Authoritarianism OT - Brief measure OT - Conspiracy mentality OT - Large-scale surveys OT - Sexism OT - Weight stigma COIS- A.H. reports receiving research grants from the German Federal Ministry of Education and Research, German Research Foundation, Innovation Fund, and Roland Ernst Foundation for Health Care; royalties for books on the treatment of eating disorders and obesity with Hogrefe and Kohlhammer; honoraria for workshops and lectures on eating disorders and obesity and their treatment; honoraria as editor of the International Journal of Eating Disorders and the journal Psychotherapeut; honoraria as a reviewer from Oxford University Press and the German Society for Nutrition; and honoraria as a consultant for WeightWatchers, Zweites Deutsches Fernsehen, Takeda, and Lilly. No other conflicts of interest were reported. The authors declare no further conflict of interest. EDAT- 2025/03/27 16:08 MHDA- 2025/10/13 06:28 PMCR- 2025/03/26 CRDT- 2025/03/26 19:26 PHST- 2024/11/04 00:00 [received] PHST- 2025/03/18 00:00 [accepted] PHST- 2025/10/13 06:28 [medline] PHST- 2025/03/27 16:08 [pubmed] PHST- 2025/03/26 19:26 [entrez] PHST- 2025/03/26 00:00 [pmc-release] AID - 000545380 [pii] AID - 545380 [pii] AID - 10.1159/000545380 [doi] PST - ppublish SO - Obes Facts. 2025;18(4):364-374. doi: 10.1159/000545380. Epub 2025 Mar 26. PMID- 40136169 OWN - NLM STAT- MEDLINE DCOM- 20250515 LR - 20250515 IS - 1678-4561 (Electronic) IS - 1413-8123 (Linking) VI - 30 IP - 3 DP - 2025 Mar TI - Association between family violence and physical activity in Brazilian adolescents: a quantile regression analysis. PG - e11582023 LID - S1413-81232025000300309 [pii] LID - 10.1590/1413-81232025303.11582023 [doi] AB - The study aims to assess the association between family physical violence and different domains of physical activity in students. Cross-sectional study with data from the National School Health Survey 2015. Physical activity was measured with a validated questionnaire and comprised the previous seven days. Physical activity domains investigated were commuting, leisure, physical education class, and total physical activity. Family physical violence was obtained with a question about exposure to physical aggression in the last month. Quantile regression analysis was performed to assess the association between exposure and outcomes, stratified by sex. Girls and boys exposed to family physical violence spent more time in commuting physical activity compared to those not exposed. Boys exposed to family physical violence spent less time in leisure physical activity compared to those not exposed, whereas girls exposed to violence spent more time in this activity than not exposed. For physical education class, exposed boys at the 80th percentile had more time for physical activity. For total physical activity, exposed girls had more time in this activity than unexposed girls. Associations were distinct for each physical activity domain by sex. FAU - Benthroldo, Raycauan Silva AU - Benthroldo RS AUID- ORCID: 0000-0001-5631-8518 AD - Departamento de Epidemiologia, Instituto de Medicina Social, Universidade do Estado do Rio de Janeiro. R. Sao Francisco Xavier 524, Maracana. 20550-900 Rio de Janeiro RJ Brasil. raycauanbenthroldo@gmail.com. FAU - Verly Junior, Eliseu AU - Verly Junior E AUID- ORCID: 0000-0002-1101-8746 AD - Departamento de Epidemiologia, Instituto de Medicina Social, Universidade do Estado do Rio de Janeiro. R. Sao Francisco Xavier 524, Maracana. 20550-900 Rio de Janeiro RJ Brasil. raycauanbenthroldo@gmail.com. FAU - Rezende, Leandro Fornias Machado de AU - Rezende LFM AUID- ORCID: 0000-0002-7469-1399 AD - Departamento de Medicina Preventiva, Escola Paulista de Medicina, Universidade Federal de Sao Paulo. Sao Paulo SP Brasil. FAU - Azeredo, Catarina Machado AU - Azeredo CM AUID- ORCID: 0000-0002-6189-4429 AD - Faculdade de Medicina, Universidade Federal de Uberlandia. Uberlandia MG Brasil. FAU - Marques, Emanuele Souza AU - Marques ES AUID- ORCID: 0000-0002-8633-7290 AD - Departamento de Epidemiologia, Instituto de Medicina Social, Universidade do Estado do Rio de Janeiro. R. Sao Francisco Xavier 524, Maracana. 20550-900 Rio de Janeiro RJ Brasil. raycauanbenthroldo@gmail.com. LA - eng PT - Journal Article DEP - 20240418 PL - Brazil TA - Cien Saude Colet JT - Ciencia & saude coletiva JID - 9713483 SB - IM MH - Humans MH - Female MH - Male MH - Brazil MH - Cross-Sectional Studies MH - Adolescent MH - *Exercise MH - *Domestic Violence/statistics & numerical data MH - Sex Factors MH - Regression Analysis MH - Health Surveys MH - Leisure Activities MH - Surveys and Questionnaires MH - Transportation/statistics & numerical data MH - *Students/statistics & numerical data MH - Child MH - Physical Education and Training/statistics & numerical data EDAT- 2025/03/26 12:31 MHDA- 2025/03/26 12:32 CRDT- 2025/03/26 11:13 PHST- 2023/07/30 00:00 [received] PHST- 2024/04/16 00:00 [accepted] PHST- 2025/03/26 12:32 [medline] PHST- 2025/03/26 12:31 [pubmed] PHST- 2025/03/26 11:13 [entrez] AID - S1413-81232025000300309 [pii] AID - 10.1590/1413-81232025303.11582023 [doi] PST - ppublish SO - Cien Saude Colet. 2025 Mar;30(3):e11582023. doi: 10.1590/1413-81232025303.11582023. Epub 2024 Apr 18. PMID- 40129662 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250326 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - Diagnostic accuracy of MUAC for assessment of acute malnutrition among children aged 6-59 months in Africa: systematic review and meta-analysis. PG - 1536386 LID - 10.3389/fnut.2025.1536386 [doi] LID - 1536386 AB - BACKGROUND: Mid-Upper Arm Circumference (MUAC) or Weight-for-Length Z-Score (WHZ) are used to screen for acute malnutrition in children. The relative merits of MUAC and WHZ, as well as whether they ought to be used separately, are still up for debate. Considering the significant impact of acute malnutrition on a large number of children in Africa, along with the constraints on resources, it is crucial to critically assess the validity of simple and widely used tools utilized in both African communities and clinical settings. Therefore, this study aimed to assess the diagnostic test accuracy of MUAC in screening acute malnutrition among children aged 6-59 months in Africa. METHODS: A systematic review and meta-analysis study was conducted to pool evidence on the diagnostic performance of MUAC compared to WHZ among children aged 6 to 59 months across various studies in Africa. The StataMP 17.0 software was utilized for analysis, employing a Bivariate Random-effects Meta-Analysis model. Sensitivity, specificity, the Diagnostic Odds Ratio, and the Area Under the Curve were calculated. Heterogeneity was assessed using Cochrane's Q statistic and the I(2) test. Additionally, meta-regression, subgroup analysis, sensitivity analysis, and assessments for publication bias were employed. The overall level of diagnostic test accuracy was estimated using a random-effects meta-analysis model. RESULTS: Seventeen studies were included in the meta-analysis. The pooled sensitivity and specificity were 38.1% (95% CI: 30.7, 46.1%) and 94.9% (95% CI: 93.2, 96.2%), respectively. The summary receiver operating characteristic curve plot showed that MUAC had good accuracy in detecting acute malnutrition (AUC = 0.85, 95% CI: 0.82, 0.88). The pooled level of diagnostic odds ratio was 13.22 (95% CI: 9.68, 16.77). The rate of misclassification in screening for acute malnutrition using MUAC was observed to be 11.7%. CONCLUSION: The MUAC demonstrated low sensitivity but high specificity in diagnosing acute malnutrition in children aged 6 to 59 months across various regions of Africa. Furthermore, it was found that MUAC provides good diagnostic test accuracy when compared to WHZ. To enhance its accuracy, it is suggested to increase the MUAC cutoff thresholds. CI - Copyright (c) 2025 Menber, Belachew and Fentahun. FAU - Menber, Yonatan AU - Menber Y AD - Department of Nutrition and Dietetics, School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia. FAU - Belachew, Tefera AU - Belachew T AD - Department of Nutrition and Dietetics, Faculty of Public Health, Institute of Health, Jimma University, Jimma, Ethiopia. FAU - Fentahun, Netsanet AU - Fentahun N AD - Department of Nutrition and Dietetics, School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia. LA - eng PT - Journal Article PT - Review DEP - 20250310 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC11930825 OTO - NOTNLM OT - Africa OT - MUAC OT - WHZ OT - acute malnutrition OT - children OT - diagnostic accuracy OT - validation COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/03/25 06:25 MHDA- 2025/03/25 06:26 PMCR- 2025/01/01 CRDT- 2025/03/25 04:37 PHST- 2024/11/30 00:00 [received] PHST- 2025/02/21 00:00 [accepted] PHST- 2025/03/25 06:26 [medline] PHST- 2025/03/25 06:25 [pubmed] PHST- 2025/03/25 04:37 [entrez] PHST- 2025/01/01 00:00 [pmc-release] AID - 10.3389/fnut.2025.1536386 [doi] PST - epublish SO - Front Nutr. 2025 Mar 10;12:1536386. doi: 10.3389/fnut.2025.1536386. eCollection 2025. PMID- 40128900 OWN - NLM STAT- MEDLINE DCOM- 20250325 LR - 20250523 IS - 1745-6215 (Electronic) IS - 1745-6215 (Linking) VI - 26 IP - 1 DP - 2025 Mar 24 TI - The effect of diverse sports skills interventions on physical fitness and brain development among Chinese high school students: a cluster randomized controlled trial study protocol. PG - 102 LID - 10.1186/s13063-025-08788-9 [doi] LID - 102 AB - BACKGROUND: During adolescence, research concerning physical fitness and brain development has become a focal point in health and neuroscience. Academic debates on the precise impact of different sports skills on adolescent physical fitness lack consensus. While exercise's positive effects on brain development in children and older adults are well-documented, its specific impact on adolescents remains unexplored. A year-long trial explores how diverse sports skills affect adolescents' physical fitness and brain development. The study has a dual focus: first, to examine the potential correlation between sports skills acquisition and indicators of adolescent physical fitness; and second, to investigate the mechanisms of brain plasticity in adolescents. This comprehensive study is poised to fill knowledge gaps, providing a scientific basis for targeted health interventions in adolescent populations. METHODS: This study will employ a randomized controlled cluster design involving senior high school students in Shanghai. The expected sample size is approximately 450 students, divided into four experimental groups and a control group. The experimental groups will undergo 1 year of sports skills training in basketball, football, tennis, and martial arts, while the control group will receive regular physical education classes. Prior to intervention, data will be collected on students' physical fitness, sports skills, levels of physical activity, and functional magnetic resonance imaging (fMRI) measurements. Rigorous control of variables will ensure comparability and experimental validity. For data analysis, specialized software tools, including SPSS 18.0, AMOS 18.0, Matlab R2013b, and EXCEL, will be employed for comprehensive analysis and interpretation, validating potential differences between experimental and control groups in various aspects of physical fitness and sports skills. DISCUSSION: This experiment aims to provide substantial scientific evidence on the impact of sports skills learning on diverse indicators of adolescent physical fitness. In addition, it aims to elucidate the effects of exercise on adolescent brain plasticity and its specific underlying mechanisms. This comprehensive evidence base is poised to serve as a basis for more effective interventions in the future, providing enhanced scientific guidance for promoting holistic adolescent development. It also provides scholars and practitioners with fresh perspectives on adolescent health development. TRIAL REGISTRATION: The study was registered at the China Clinical Trial Registry (ChiCTR2300070942). https://www.chictr.org.cn . Registered on April 10, 2023. CI - (c) 2025. The Author(s). FAU - Ke, Youzhi AU - Ke Y AD - School of Physical Education, Shanghai University of Sport, 650 Qingyuanhuan Road, Shanghai, 200438, China. FAU - Bao, Menghan AU - Bao M AD - Xinjiangwan Experimental School affiliated to Tongji University, Shanghai, 200433, China. FAU - Qu, Xuliang AU - Qu X AD - High School Affiliated to Fudan University, Pudong Campus, Shanghai, 201209, China. FAU - Yan, Yiping AU - Yan Y AD - School of Physical Education, Shanghai University of Sport, 650 Qingyuanhuan Road, Shanghai, 200438, China. FAU - Li, Li AU - Li L AD - Educational Institute of Yangpu District Shanghai, Shanghai, 200093, China. FAU - Wang, Yemei AU - Wang Y AD - Educational Institute of Minhang District Shanghai, Shanghai, 200241, China. FAU - Wu, Yeli AU - Wu Y AD - Educational Institute of Xuhui District Shanghai, Shanghai, 200032, China. FAU - Li, Xiaokai AU - Li X AD - School of Exercise and Health, Shanghai University of Sport, 650 Qingyuanhuan Road, Shanghai, 200438, China. lxkmoon@126.com. FAU - Liu, Yang AU - Liu Y AUID- ORCID: 0000-0003-1251-3025 AD - School of Physical Education, Shanghai University of Sport, 650 Qingyuanhuan Road, Shanghai, 200438, China. docliuyang@hotmail.com. AD - Shanghai Research Center for Physical Fitness and Health of Children and Adolescents, Shanghai University of Sport, 650 Qingyuanhuan Road, Shanghai, 200438, China. docliuyang@hotmail.com. AD - Physical Education National Experimental Teaching Demonstration Center, Shanghai University of Sport, 650 Qingyuanhuan Road, Shanghai, 200438, China. docliuyang@hotmail.com. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20250324 PL - England TA - Trials JT - Trials JID - 101263253 RN - Chinese people SB - IM MH - Humans MH - Adolescent MH - *Brain/growth & development/diagnostic imaging/physiology MH - China MH - Randomized Controlled Trials as Topic MH - *Physical Fitness MH - Magnetic Resonance Imaging MH - Male MH - Female MH - *Adolescent Development MH - *Sports MH - Neuronal Plasticity MH - Students MH - *Physical Education and Training/methods MH - Motor Skills MH - East Asian People PMC - PMC11931799 OTO - NOTNLM OT - Brain OT - Health promotion OT - Physical fitness OT - Sports skills OT - Youth COIS- Declarations. Ethics approval and consent to participate 24: This study was approved by the Institutional Review Board (IRB) of the Shanghai University of Sport (SUS) (102772022RT031). Written informed consent will be obtained from all participants. The investigators will ensure that this trial is conducted by relevant Chinese clinical trial research norms and regulations. Consent for publication 32: All authors grant consent for publication. Competing interests 28: The authors declare that they have no competing interests. EDAT- 2025/03/25 06:25 MHDA- 2025/03/25 06:26 PMCR- 2025/03/24 CRDT- 2025/03/25 00:53 PHST- 2023/12/26 00:00 [received] PHST- 2025/03/04 00:00 [accepted] PHST- 2025/03/25 06:26 [medline] PHST- 2025/03/25 06:25 [pubmed] PHST- 2025/03/25 00:53 [entrez] PHST- 2025/03/24 00:00 [pmc-release] AID - 10.1186/s13063-025-08788-9 [pii] AID - 8788 [pii] AID - 10.1186/s13063-025-08788-9 [doi] PST - epublish SO - Trials. 2025 Mar 24;26(1):102. doi: 10.1186/s13063-025-08788-9. PMID- 40127963 OWN - NLM STAT- MEDLINE DCOM- 20250514 LR - 20250514 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 9 IP - 1 DP - 2025 Mar 24 TI - Assessment of dietary, genetic and metabolic factors in South Indian adolescents with metabolic dysfunction-associated steatotic liver disease: a case-control study protocol. LID - 10.1136/bmjpo-2024-003138 [doi] LID - e003138 AB - INTRODUCTION: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of liver disease among adolescents. The objectives of this study are to investigate the associations of dietary, genetic and metabolic factors with MASLD in South Indian adolescents. METHODS AND ANALYSIS: The study will employ a case-control study design. We will recruit 280 adolescents (140 cases and 140 controls) from hospital and school settings. The hospital setting will be the paediatric gastroenterology outpatient department (OPD) at the study institution and the school setting will be selected urban schools from Ernakulam, Kerala. At the hospital, cases and controls will be selected from the patients who are attending the paediatric gastroenterology OPD with complaints of generalised abdominal pain or constipation with no other significant medical complaints or use of medications. A sensitisation programme on MASLD for parents of adolescents will be conducted in schools. All consenting parents along with their adolescent wards will be invited for study participation. Cases will be defined as adolescents having evidence of hepatic steatosis in ultrasound and meeting any one of the paediatric cardiometabolic criteria for MASLD. Those who fail to satisfy this criteria will be defined as controls. All participants will undergo nutritional and physical activity assessments using validated questionnaires along with blood sampling for biochemical analysis and genetic testing. We will examine the associations between MASLD and dietary parameters using Pearson's chi(2) tests after stratifying dietary variables into categorical groups. Logistic regression will be used to assess the impact of dietary parameters and single-nucleotide polymorphisms (SNPs) on the risk of MASLD. ETHICS AND DISSEMINATION: Ethics approval was obtained from the Ethics Committee of Amrita School of Medicine, Kochi. Informed consent will be obtained from participants and their legal guardians before enrolment. The study findings will provide valuable insights into the evolution of MASLD among adolescents in South India. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Venu, Swathilakshmi AU - Venu S AUID- ORCID: 0009-0007-2959-7161 AD - Amrita Institute of Medical Sciences and Research Centre, Ernakulam, Kerala, India. FAU - Gopalakrishna, Rajesh AU - Gopalakrishna R AD - Department of Gastroenterology and Hepatology, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India. FAU - Pillai, Bhanu Vikraman AU - Pillai BV AUID- ORCID: 0009-0006-5473-9320 AD - Department of Gastroenterology and Hepatology, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India. FAU - Biswas, Lalitha AU - Biswas L AUID- ORCID: 0000-0002-1317-2579 AD - Amrita Vishwa Vidyapeetham, Coimbatore, Tamil Nadu, India. FAU - Poojara, Rashmi AU - Poojara R AUID- ORCID: 0000-0003-4906-7284 AD - Department of Home Science, St Teresa's College, Ernakulam, Kerala, India. FAU - Raj, Manu AU - Raj M AUID- ORCID: 0000-0001-7130-3437 AD - Department of Pediatrics, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India drmanuraj@gmail.com. LA - eng PT - Journal Article DEP - 20250324 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Adolescent MH - Case-Control Studies MH - India/epidemiology MH - *Fatty Liver/genetics/epidemiology/etiology/metabolism MH - Male MH - Female MH - *Diet MH - Risk Factors PMC - PMC11934355 OTO - NOTNLM OT - Adolescent Health OT - Gastroenterology OT - Genetics OT - Obesity COIS- Competing interests: None declared. EDAT- 2025/03/25 00:38 MHDA- 2025/03/25 00:39 PMCR- 2025/03/24 CRDT- 2025/03/24 21:23 PHST- 2024/10/18 00:00 [received] PHST- 2025/03/02 00:00 [accepted] PHST- 2025/03/25 00:39 [medline] PHST- 2025/03/25 00:38 [pubmed] PHST- 2025/03/24 21:23 [entrez] PHST- 2025/03/24 00:00 [pmc-release] AID - 10.1136/bmjpo-2024-003138 [pii] AID - bmjpo-2024-003138 [pii] AID - 10.1136/bmjpo-2024-003138 [doi] PST - epublish SO - BMJ Paediatr Open. 2025 Mar 24;9(1):e003138. doi: 10.1136/bmjpo-2024-003138. PMID- 40127734 OWN - NLM STAT- MEDLINE DCOM- 20250506 LR - 20260813 IS - 1541-6100 (Electronic) IS - 0022-3166 (Print) IS - 0022-3166 (Linking) VI - 155 IP - 5 DP - 2025 May TI - Validation of the Latin American and Caribbean Food Security Scale (ELCSA) for use in Samoa. PG - 1474-1484 LID - S0022-3166(25)00175-0 [pii] LID - 10.1016/j.tjnut.2025.03.023 [doi] AB - BACKGROUND: Measuring food security accurately has implications for policies and programming designed to address both hunger and obesity risk among children. OBJECTIVES: We aimed to examine the validity of the Latin American and Caribbean Food Security Scale (ELCSA) for use in Samoa. METHODS: The ELCSA was administered verbally to 454 Samoan mothers who were participants in an ongoing longitudinal cohort study (the Ola Tuputupua'e Study). Internal consistency and construct validity were examined with Rasch modeling, which generated item severity and item infit statistics. Associations between food security and several cohort characteristics including maternal education, household income, and child dietary intake were examined to determine whether common associations present in the extant literature could be replicated. Face and content validity were explored through focus group discussions with n = 34 of the participants. RESULTS: The ELCSA showed strong reliability and internal consistency and, with minor exceptions, participants clearly understood the survey questions. On the basis of Rasch modeling, the score thresholds for food insecurity used in the original tool are appropriate for use in Samoa. Many families in Samoa experience some degree of food insecurity, primarily driven by a lack of access to "healthy" foods, although extreme food insecurity was infrequent. The managed process of food insecurity is largely consistent with that found elsewhere, although uniquely protective factors such as continued subsistence farming and community food sharing mitigate the absolute lack of food for most families. CONCLUSIONS: The Samoan translation of the 15-question ELCSA has validity for use among nonpregnant Samoan women with children. Although there are unique protective factors, food insecurity should be continuously monitored in Samoa with efforts made to provide resources to families experiencing extreme food insecurity. CI - Copyright (c) 2025 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Tanawattanacharoen, Veeraya K AU - Tanawattanacharoen VK AD - Department of Chronic Disease Epidemiology, Yale University School of Public Health, New Haven, CT, United States. FAU - Choy, Courtney C AU - Choy CC AD - Department of Chronic Disease Epidemiology, Yale University School of Public Health, New Haven, CT, United States. FAU - Anesi, Trevor J AU - Anesi TJ AD - Department of Epidemiology, School of Public Health, Brown University, Providence, RI, United States. FAU - Hromi-Fiedler, Amber AU - Hromi-Fiedler A AD - Department of Social and Behavioral Sciences, Yale University School of Public Health, New Haven, CT, United States. FAU - Naseri, Take AU - Naseri T AD - Department of Epidemiology, School of Public Health, Brown University, Providence, RI, United States; Samoa Ministry of Health, Apia, Samoa. FAU - Reupena, Muagututia S AU - Reupena MS AD - Lutia i Puava ae Mapu i Fagalele, Apia, Samoa. FAU - Duckham, Rachel L AU - Duckham RL AD - Australian Institute for Musculoskeletal Sciences, The University of Melbourne and Western Health, St. Albans, Victoria, Australia; Institute for Physical Activity and Nutrition, Deakin University, Burwood, Victoria, Australia. FAU - Wang, Dongqing AU - Wang D AD - Department of Global and Community Health, College of Public Health, George Mason University, Fairfax, VA, United States. FAU - Hawley, Nicola L AU - Hawley NL AD - Department of Chronic Disease Epidemiology, Yale University School of Public Health, New Haven, CT, United States. Electronic address: nicola.hawley@yale.edu. FAU - Soti-Ulberg, Christina AU - Soti-Ulberg C AD - Samoa Ministry of Health, Apia, Samoa. LA - eng GR - K99 HL166781/HL/NHLBI NIH HHS/United States GR - D43 TW010540/TW/FIC NIH HHS/United States GR - T32 HD007338/HD/NICHD NIH HHS/United States GR - T37 MD008655/MD/NIMHD NIH HHS/United States GR - R01 HL093093/HL/NHLBI NIH HHS/United States GR - F31 HL147414/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250322 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 SB - IM MH - Humans MH - *Food Security MH - Female MH - Caribbean Region MH - Samoa MH - Adult MH - Latin America MH - Reproducibility of Results MH - Longitudinal Studies MH - Surveys and Questionnaires MH - Food Insecurity MH - Male MH - *Food Supply MH - Child PMC - PMC12121424 OTO - NOTNLM OT - Samoa OT - childhood OT - food security OT - hunger OT - obesity OT - validation COIS- Conflict of interest Courtney Choy reports financial support was provided by National Institutes of Health. Other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/03/25 00:38 MHDA- 2025/05/06 06:30 PMCR- 2026/03/22 CRDT- 2025/03/24 20:32 PHST- 2024/11/27 00:00 [received] PHST- 2025/03/14 00:00 [revised] PHST- 2025/03/19 00:00 [accepted] PHST- 2025/05/06 06:30 [medline] PHST- 2025/03/25 00:38 [pubmed] PHST- 2025/03/24 20:32 [entrez] PHST- 2026/03/22 00:00 [pmc-release] AID - S0022-3166(25)00175-0 [pii] AID - 10.1016/j.tjnut.2025.03.023 [doi] PST - ppublish SO - J Nutr. 2025 May;155(5):1474-1484. doi: 10.1016/j.tjnut.2025.03.023. Epub 2025 Mar 22. PMID- 40126070 OWN - NLM STAT- MEDLINE DCOM- 20250501 LR - 20260714 IS - 1540-2010 (Electronic) IS - 1540-2002 (Linking) VI - 23 IP - 3 DP - 2025 May-Jun TI - Actigraphy Estimated Night Sleep Duration in Preschool Children: Comparison of an Automated Algorithm and Sleep Diary Against the Sadeh Algorithm. PG - 436-446 LID - 10.1080/15402002.2025.2481439 [doi] AB - OBJECTIVES: This study aims to compare amongst preschoolers, night sleep duration derived using the automated van Hees algorithm in GGIR (GGIR_VH) against the reference Sadeh algorithm (Actilife_SD), and subjective caregiver-reported sleep diaries against Actilife_SD. METHODS: Participants were 142 preschoolers (52.1% males), age 5.5 years, from the Growing Up in Singapore Toward healthy Outcomes (GUSTO) birth cohort study. Weeklong actigraphy data was collected via the wGT3X-BT accelerometer (worn on the non-dominant wrist) with concurrent caregiver-reported sleep diaries. Analyses were conducted to compare the automated GGIR_VH and sleep diaries against the reference Actilife_SD. Intraclass correlations were calculated to compare the agreement levels. Bland-Altman plots were used to investigate the bias in the mean differences and limits of agreement (LoA). Repeated measures of ANOVAs were used to compare mean differences. RESULTS: For the intraclass correlation between automated GGIR_VH and reference Actilife_SD, there was moderate agreement for the nighttime total sleep duration (r = 0.66) and poor agreement between diary and Actilife_SD (r = 0.04). Bland-Altman plots revealed a positive bias when comparing diaries against Actilife_SD, where diaries reported longer sleep duration. In contrast, there was almost no bias and smaller LoAs for the comparison between GGIR_VH and Actilife_SD. ANOVAs showed that comparisons between diary (M = 9.36, SD = 1.16) and Actilife_SD (M = 6.93, SD = 1.12); and GGIR_VH (M = 6.76, SD = 1.30) and Actilife_SD both yielded significant differences. CONCLUSIONS: Overall, the automated GGIR_VH algorithm showed moderate agreement compared to the reference Actilife_SD. In contrast, sleep diaries overestimated sleep duration when compared to Actilife_SD. FAU - Tham, Elaine Kh AU - Tham EK AD - Institute for Human Development and Potential, Agency for Science, Technology and Research (A*STAR), Singapore. FAU - Tang, Bernard AU - Tang B AD - Institute for Human Development and Potential, Agency for Science, Technology and Research (A*STAR), Singapore. FAU - Padmapriya, Natarajan AU - Padmapriya N AD - Saw Swee Hock School of Public Health, National University of Singapore, Singapore. AD - Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. FAU - Rema, Anu Ss AU - Rema AS AD - Institute for Human Development and Potential, Agency for Science, Technology and Research (A*STAR), Singapore. FAU - Bernard, Jonathan Y AU - Bernard JY AD - Universite Paris Cite and Universite Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France. FAU - Gluckman, Peter D AU - Gluckman PD AD - Institute for Human Development and Potential, Agency for Science, Technology and Research (A*STAR), Singapore. AD - Liggins Institute, University of Auckland, Auckland, New Zealand. FAU - Chong, Yap-Seng AU - Chong YS AD - Institute for Human Development and Potential, Agency for Science, Technology and Research (A*STAR), Singapore. AD - Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. FAU - Yap, Fabian AU - Yap F AD - Department of Paediatric Endocrinology, KK Women's and Children's Hospital, Singapore. FAU - Eriksson, Johan G AU - Eriksson JG AD - Institute for Human Development and Potential, Agency for Science, Technology and Research (A*STAR), Singapore. AD - Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. AD - Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland. AD - Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. FAU - Muller-Riemenschneider, Falk AU - Muller-Riemenschneider F AD - Saw Swee Hock School of Public Health, National University of Singapore, Singapore. AD - Digital Health Center, Berlin Institute of Health, Charite-Universitatsmedizin Berlin, Berlin, Germany. FAU - Cai, Shirong AU - Cai S AD - Institute for Human Development and Potential, Agency for Science, Technology and Research (A*STAR), Singapore. AD - Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250324 PL - England TA - Behav Sleep Med JT - Behavioral sleep medicine JID - 101149327 SB - IM MH - Humans MH - Male MH - Female MH - Child, Preschool MH - *Actigraphy/methods MH - *Algorithms MH - *Sleep/physiology MH - Singapore MH - Diaries as Topic MH - Time Factors MH - Sleep Duration EDAT- 2025/03/24 12:46 MHDA- 2025/05/01 18:29 CRDT- 2025/03/24 09:33 PHST- 2025/05/01 18:29 [medline] PHST- 2025/03/24 12:46 [pubmed] PHST- 2025/03/24 09:33 [entrez] AID - 10.1080/15402002.2025.2481439 [doi] PST - ppublish SO - Behav Sleep Med. 2025 May-Jun;23(3):436-446. doi: 10.1080/15402002.2025.2481439. Epub 2025 Mar 24. PMID- 40125526 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260524 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 17 IP - 3 DP - 2025 Mar TI - Causality of Childhood and Adult Body Mass Index on Sick Sinus Syndrome: A Mendelian Randomization Study. PG - e80913 LID - 10.7759/cureus.80913 [doi] LID - e80913 AB - Background The relationship between body mass index (BMI) and the risk of sick sinus syndrome (SSS) remains unclear. Clarifying the impact of BMI on SSS at different life stages is essential for advancing precision medicine and implementing effective prevention strategies to reduce the burden of SSS. Methods The causalities of childhood and adult BMI with SSS were investigated by univariate and multivariate Mendelian randomization. Reverse causalities were also explored to improve the accuracy of causality findings. Different sources of exposure data were used for replication analysis, and the effects of sample overlap were investigated using MRlap. The stability of the results was further enhanced through meta-analysis. Results There was a positive correlation of adult BMI with the risk of SSS in both the FinnGen (odds ratio (OR) = 1.17, 95% confidence interval (CI) 1.01-1.35, P = 0.031) and Integrative Epidemiology Unit (IEU) open genome-wide association study (GWAS) project (OR = 1.18, 95% CI 1.04-1.34, P = 0.009) databases. The causality remained valid after the correction of telomere length. There was no causality detected between childhood BMI and SSS, as determined by independent studies of the Early Growth Genetics (EGG) 2020 (OR = 1.06, 95% CI 0.89-1.27, P = 0.513) and EGG2015 (OR = 1.02, 95% CI 0.97-1.09, P = 0.423). Meta-analysis results further confirmed the reliability of the causal inference. Conclusions The findings indicate that elevated BMI in adults, particularly among middle-aged and elderly populations, increases the risk of developing SSS. In contrast, no causal relationship was observed between childhood BMI and SSS, suggesting that the influence of BMI on SSS susceptibility may predominantly emerge during later life stages. These results highlight the need for targeted public health interventions to address adult obesity as a modifiable risk factor for SSS. CI - Copyright (c) 2025, Xu et al. FAU - Xu, Guanzhen AU - Xu G AD - Graduate School, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, CHN. FAU - Liu, Zhuang AU - Liu Z AD - Cardiology Department, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, CHN. FAU - Hou, Ping AU - Hou P AD - Graduate School, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, CHN. AD - Cardiology Department, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, CHN. LA - eng PT - Journal Article DEP - 20250320 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC11929112 OTO - NOTNLM OT - body mass index OT - causality OT - life course epidemiology OT - mendelian randomization OT - sick sinus syndrome COIS- Human subjects: All authors have confirmed that this study did not involve human participants or tissue. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: This work was supported by the National Natural Science Foundation (81874403). Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2025/03/24 12:46 MHDA- 2025/03/24 12:47 PMCR- 2025/03/20 CRDT- 2025/03/24 06:19 PHST- 2025/03/19 00:00 [accepted] PHST- 2025/03/24 12:47 [medline] PHST- 2025/03/24 12:46 [pubmed] PHST- 2025/03/24 06:19 [entrez] PHST- 2025/03/20 00:00 [pmc-release] AID - 10.7759/cureus.80913 [doi] PST - epublish SO - Cureus. 2025 Mar 20;17(3):e80913. doi: 10.7759/cureus.80913. eCollection 2025 Mar. PMID- 40124125 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250325 IS - 2055-7647 (Print) IS - 2055-7647 (Electronic) IS - 2055-7647 (Linking) VI - 11 IP - 1 DP - 2025 TI - Changes in physical fitness in transgender adolescents receiving gender-affirming hormone therapy: protocol for a prospective cohort pilot study. PG - e002477 LID - 10.1136/bmjsem-2025-002477 [doi] LID - e002477 AB - There is very little data about the physical fitness of transgender and gender-diverse (TGD) youth. This protocol paper describes the methods for a pilot study that aims to measure changes in fitness levels in TGD adolescents undergoing gender-affirming hormone therapy (GAHT) using FitnessGram, a reliable, validated tool used to measure physical fitness. A secondary aim of the study is to compare the physical fitness of TGD adolescents with normative data for cisgender individuals. This will be a prospective cohort study. We will recruit 25 TGD participants who are 13-18 years old and patients in our organisation's Gender Development Clinic, planning to initiate GAHT. Participants will complete FitnessGram before starting GAHT and undergo repeat assessments 6 months and 12 months after GAHT initiation. Participants will also complete the Physical Activity Questionnaire for Adolescents. We plan to report changes in the participant's ability to achieve the FitnessGram standards over 12 months. Secondary outcomes will include a comparison of the achievement of the FitnessGram standards in the cohort with the reported achievement of standards for cisgender adolescents. CI - Copyright (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Wolf, Sigrid F AU - Wolf SF AUID- ORCID: 0009-0000-9066-3374 AD - Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA. AD - Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Kuhns, Lisa M AU - Kuhns LM AD - Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA. AD - Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Voss, Raina V AU - Voss RV AD - Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA. AD - Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Rybacki, Delanie L AU - Rybacki DL AD - Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA. FAU - Carl, Rebecca L AU - Carl RL AUID- ORCID: 0000-0001-7642-9872 AD - Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA. AD - Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Burgess, Jamie K AU - Burgess JK AD - Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA. AD - Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Baptiste, Summer AU - Baptiste S AD - Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA. FAU - Garofalo, Robert AU - Garofalo R AD - Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA. AD - Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. LA - eng PT - Journal Article DEP - 20250317 PL - England TA - BMJ Open Sport Exerc Med JT - BMJ open sport & exercise medicine JID - 101681007 PMC - PMC11927488 OTO - NOTNLM OT - Adolescent OT - Gender OT - Physical fitness COIS- RLC is chair for the AAP Council on Sports Medicine and Fitness. She receives travel reimbursement when she travels on their behalf to conferences and has received small honorariums (a total of US$700) for speaking and writing engagements. EDAT- 2025/03/24 12:46 MHDA- 2025/03/24 12:47 PMCR- 2025/03/17 CRDT- 2025/03/24 06:01 PHST- 2025/02/06 00:00 [received] PHST- 2025/02/17 00:00 [accepted] PHST- 2025/03/24 12:47 [medline] PHST- 2025/03/24 12:46 [pubmed] PHST- 2025/03/24 06:01 [entrez] PHST- 2025/03/17 00:00 [pmc-release] AID - bmjsem-2025-002477 [pii] AID - 10.1136/bmjsem-2025-002477 [doi] PST - epublish SO - BMJ Open Sport Exerc Med. 2025 Mar 17;11(1):e002477. doi: 10.1136/bmjsem-2025-002477. eCollection 2025. PMID- 40123785 OWN - NLM STAT- MEDLINE DCOM- 20250514 LR - 20260505 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 12 DP - 2024 TI - Compliance with the 24-hour movement guidelines and weight status: results from 40,970 adolescents. PG - 1472188 LID - 10.3389/fpubh.2024.1472188 [doi] LID - 1472188 AB - BACKGROUND: Childhood obesity, which has been associated to heart disease, metabolic syndrome and disorders such as feelings of worry and sadness in children is one of the prominent obstacles for the health of the general population in the recent decades. A great deal of research shown the connection between meeting the 24-hour movement guidelines and weight status in young people. The purpose of this study is to find the correlation between compliance with the 24-hour movement guidelines and weight status in a large collection of U.S. teenagers, and to examine whether these connections vary by sex, age, or ethnicity/race. METHODS: The study was gathered from the Youth Risk Behaviour Survey (YRBS) conducted in 2017, 2019, and 2021, the final analysis used a total of 40,970 participants aged 14-17 years. The study used logistic regression analysis to estimate the correlation between adherent to the 24-hour movement guidelines (independent) and weight status (dependent) while adjusting for sex, age, race/ethnicity, grade, eating habits, cigarette use, alcohol drinking, perception of weight, weight loss, sports team participation, and year of data acquisition. For statistical significance, a p-value <0.05was used. RESULTS: Participators who not meeting any guidelines (OR = 1.38, CI = 1.20-1.58, p < 0.001), 1 guideline (OR = 1.42, CI = 1.28-1.58, p < 0.001), and 2 guidelines (OR = 1.18, CI = 1.20-1.58, p < 0.001) were more associated with worse weight status, compared with those who met the 3 guideline. For boys, who did not meet any of the guidelines (OR = 1.63, CI = 1.37-1.93, p < 0.001), 1 guideline (OR = 1.49, CI = 1.31-1.70, p < 0.001), and 2 guidelines (OR = 1.16, CI = 1.00-1.34, p = 0.048) were correlated with unfavourable weight status compared with who met all guidelines were more associated. The disaggregated results for gender, age, race, and ethnic group shows that the impact of not adhering to movement guidelines is more pronounced in boys than in girls, each age group demonstrates a trend where not meeting guidelines correlates with poorer weight status, White and Hispanic/Latino participants exhibit stronger negative outcomes from poor guideline adherence compared to other groups. CONCLUSION: This research suggests that meeting the 24-hour movement guidelines can significantly aid in averting weight-related problems among U.S. adolescents, with pronounced differences across sex, age, race/ethnicity subgroups. To validate these preliminary findings, future research should employ longitudinal designs to examine the differences among various age groups, sexes, and races, and to determine if promoting adherence to these movement guidelines effectively mitigates weight-related issues during adolescence. CI - Copyright (c) 2025 Su. FAU - Su, Yang AU - Su Y AD - School of Humanity and Physical Education, Nanjing Sport Institute, Nanjing, China. LA - eng PT - Journal Article DEP - 20250307 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - *Body Weight MH - United States MH - *Exercise MH - *Guideline Adherence/statistics & numerical data MH - *Pediatric Obesity/prevention & control MH - *Guidelines as Topic MH - Surveys and Questionnaires PMC - PMC11925785 OTO - NOTNLM OT - 24-hour movement OT - 24-hour movement guidelines OT - Youth Risk Behaviour Survey OT - adolescent OT - weight status COIS- The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/03/24 06:30 MHDA- 2025/03/24 12:46 PMCR- 2025/03/07 CRDT- 2025/03/24 05:56 PHST- 2024/07/29 00:00 [received] PHST- 2024/12/31 00:00 [accepted] PHST- 2025/03/24 12:46 [medline] PHST- 2025/03/24 06:30 [pubmed] PHST- 2025/03/24 05:56 [entrez] PHST- 2025/03/07 00:00 [pmc-release] AID - 10.3389/fpubh.2024.1472188 [doi] PST - epublish SO - Front Public Health. 2025 Mar 7;12:1472188. doi: 10.3389/fpubh.2024.1472188. eCollection 2024. PMID- 40122955 OWN - NLM STAT- MEDLINE DCOM- 20250514 LR - 20250514 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Mar 24 TI - Reliability of the biceps curl test and proposed percentiles in schoolchildren living at moderate altitude in Peru. PG - 10045 LID - 10.1038/s41598-025-89656-z [doi] LID - 10045 AB - The biceps curl test is easy to apply, does not require expensive equipment, and its short execution time makes it feasible in school settings with limited resources. To verify the reliability of the biceps curl test in children and adolescents and to provide reference values according to chronological age and sex. A total of 1103 schoolchildren aged 6 to 17 years (500 boys and 603 girls) were evaluated. Weight and height were evaluated and Body Mass Index (BMI) and Tri Ponderal Index (TPI) were calculated. The right and left hand biceps curl was evaluated in 30 s. Children aged 6 to 11 years used a 1 kg dumbbell and those aged 12 to 17 years used a 2 kg dumbbell. Percentiles were calculated using the LMS method. The values of the relative Technical Error of Measurement (TEM%) of the biceps curl test of both hands ranged from 0.48 to 2.89%. The intraclass correlation coefficient (ICC) evidenced high values of 0.93 to 0.99. The Bland-Altman plot showed wide limits of agreement (-1.28 to 1.29 rep). These findings demonstrate that the test is reliable and consistent for use in pediatric populations and is suitable for different stages of physical development in school children. The values showed stability and wide limits of agreement. In addition, the proposed percentiles are useful to evaluate and monitor the strength endurance performance of both arms. CI - (c) 2025. The Author(s). FAU - Cossio-Bolanos, Marco AU - Cossio-Bolanos M AD - Universidad San Ignacio de Loyola, Lima, Peru. mcossio1972@hotmail.com. FAU - Vidal-Espinoza, Ruben AU - Vidal-Espinoza R AD - Universidad Catolica Silva Henriquez, Santiago, Chile. FAU - Sulla-Torres, Jose AU - Sulla-Torres J AD - Escuela de Ingenieria de Sistemas, Universidad Catolica de Santa Maria, Arequipa, Peru, Peru. FAU - Castelli Correia de Campos, Luis Felipe AU - Castelli Correia de Campos LF AD - Nucleo de Investigacion en Ciencias de la Motricidad Humana, Universidad Adventista de Chile, Chillan, Chile. FAU - de Arruda, Miguel AU - de Arruda M AD - Universidad Estadual de Campinas, Sao Paulo, Brasil. FAU - Olivares, Pedro R AU - Olivares PR AD - Faculty of Education, Psychology and Sports Sciences, University of Huelva, Huelva, Spain. FAU - Torres-Paz, Luis Edwin AU - Torres-Paz LE AD - Universidad Cesar Vallejo, Trujillo, Peru. FAU - Gomez-Campos, Rossana AU - Gomez-Campos R AD - Universidad San Ignacio de Loyola, Lima, Peru. LA - eng PT - Journal Article DEP - 20250324 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - Adolescent MH - Peru MH - Reproducibility of Results MH - *Altitude MH - Body Mass Index MH - *Muscle Strength/physiology MH - *Muscle, Skeletal/physiology PMC - PMC11930944 OTO - NOTNLM OT - Adolescents OT - Altitude OT - Biceps curl OT - Children OT - Pediatric strength OT - Reliability COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/03/24 06:30 MHDA- 2025/03/24 06:31 PMCR- 2025/03/24 CRDT- 2025/03/24 00:21 PHST- 2024/06/17 00:00 [received] PHST- 2025/02/06 00:00 [accepted] PHST- 2025/03/24 06:31 [medline] PHST- 2025/03/24 06:30 [pubmed] PHST- 2025/03/24 00:21 [entrez] PHST- 2025/03/24 00:00 [pmc-release] AID - 10.1038/s41598-025-89656-z [pii] AID - 89656 [pii] AID - 10.1038/s41598-025-89656-z [doi] PST - epublish SO - Sci Rep. 2025 Mar 24;15(1):10045. doi: 10.1038/s41598-025-89656-z. PMID- 40122828 OWN - NLM STAT- MEDLINE DCOM- 20250514 LR - 20250523 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 25 IP - 1 DP - 2025 Mar 24 TI - Clustering unhealthy lifestyle factors in Chinese children and adolescents with overweight or obesity. PG - 226 LID - 10.1186/s12887-025-05567-y [doi] LID - 226 AB - BACKGROUND: This study used latent class analysis (LCA) to examine the potential patterns of unhealthy lifestyle factors (ULFs) and their association with overweight and obesity in children and adolescents with overweight or obesity in China. METHODS: We conducted three cross-sectional surveys, recruiting 7,927 children with obesity or overweight from September 2019 to January 2022. We used LCA to identify patterns of co-occurrence of ULFs based on seven types of behaviors. Multinomial logistic regression model was constructed to examine the association of fetal and neonatal factors with the clusters of ULFs. RESULTS: Of 7,927 participants, 7,627 (96.78%) had at least one ULF, and 6,942 (87.57%) had two or more ULFs concurrently. Using LCA, four distinct clusters were identified based on the elbow point of the Akaike's information criterion (AIC), that is, "unhealthy food intake but long sleeping", "relative health", "healthy food intake but unhealthy eating-sleeping-sitting habits", and "unhealthy food intake and unhealthy sitting-activity habits". Moreover, several factors including sex, age, infancy feeding, parental obesity, and parental age were significantly associated with the clusters of ULFs. CONCLUSIONS: We provide evidence on how multiple ULFs in combination may influence health among Chinese children and adolescents with overweight or obesity, and we agree that further external validations are warranted. CLINICAL TRIAL NUMBER: Not applicable. CI - (c) 2025. The Author(s). FAU - Wang, Qiong AU - Wang Q AD - Graduate School, Beijing University of Chinese Medicine, Beijing, China. AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China. FAU - Yang, Min AU - Yang M AD - China Academy of Chinese Medical Sciences, Beijing, China. AD - Department of Acupuncture and Moxibustion, Guang'anmen Hospital, Beijing, China. FAU - Chen, Kening AU - Chen K AD - Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Zheng, Fangjieyi AU - Zheng F AD - Center for Evidence-Based Medicine, Capital Institute of Pediatrics, No.2 Yabao Rd., Chaoyang District, 100020, Beijing, China. FAU - Zhang, Zhixin AU - Zhang Z AD - Institute of Clinical Medicine, China-Japan Friendship Hospital, No.2 Yinghua East Street, Chaoyang District, 100029, Beijing, China. zhangzhixin032@163.com. FAU - Niu, Wenquan AU - Niu W AD - Center for Evidence-Based Medicine, Capital Institute of Pediatrics, No.2 Yabao Rd., Chaoyang District, 100020, Beijing, China. niuwenquan_shcn@163.com. LA - eng PT - Journal Article DEP - 20250324 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 RN - Chinese people SB - IM MH - Humans MH - Female MH - Male MH - Adolescent MH - *Pediatric Obesity/epidemiology MH - Child MH - Cross-Sectional Studies MH - China/epidemiology MH - *Life Style MH - *Overweight/epidemiology MH - Latent Class Analysis MH - Cluster Analysis MH - East Asian People PMC - PMC11931837 OTO - NOTNLM OT - Children OT - Latent class analysis OT - Overweight or obesity OT - Unhealthy lifestyle factors COIS- Declarations. Ethics approval and consent to participate: The first two surveys were approved by the Ethics Committee of China-Japan Friendship Hospital, and the third survey by the Ethics Committees of Beijing University of Chinese Medicine, in compliance with the principles of the Declaration of Helsinki. The privacy of personal information was protected throughout the study via anonymous data collection, and confidentiality was maintained by asking participants to provide honest answers. Informed consent to participate has been obtained from the parents or legal guardians of any participants under the age of 16. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/03/24 06:30 MHDA- 2025/03/24 06:31 PMCR- 2025/03/24 CRDT- 2025/03/24 00:14 PHST- 2025/01/14 00:00 [received] PHST- 2025/03/04 00:00 [accepted] PHST- 2025/03/24 06:31 [medline] PHST- 2025/03/24 06:30 [pubmed] PHST- 2025/03/24 00:14 [entrez] PHST- 2025/03/24 00:00 [pmc-release] AID - 10.1186/s12887-025-05567-y [pii] AID - 5567 [pii] AID - 10.1186/s12887-025-05567-y [doi] PST - epublish SO - BMC Pediatr. 2025 Mar 24;25(1):226. doi: 10.1186/s12887-025-05567-y. PMID- 40122564 OWN - NLM STAT- MEDLINE DCOM- 20250514 LR - 20250514 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 3 DP - 2025 Mar 22 TI - Cohort profile: the Genetics of Glucose regulation in Gestation and Growth (Gen3G) - a prospective prebirth cohort of mother-child pairs in Sherbrooke, Canada, 3-year and 5-year follow-up visits. PG - e093434 LID - 10.1136/bmjopen-2024-093434 [doi] LID - e093434 AB - PURPOSE: Initiated in 2010, the Genetics of Glucose regulation in Gestation and Growth (Gen3G) prospective cohort investigates the pathophysiology of impaired glycaemic regulation in pregnancy and evaluates its impact on both the mothers and her offspring health trajectory. Follow-up visits 3 and 5 years after delivery aimed to investigate pregnancy-related risk factors such as maternal obesity and gestational hyperglycaemia in relation to the mother's metabolic health after pregnancy, and with offspring health outcomes such as risk of obesity and neurodevelopmental problems in early childhood. We also investigated molecular mechanisms involved in the fetal programming of these later health outcomes. PARTICIPANTS: Of the 1024 women originally recruited in the first trimester of pregnancy, we have targeted the 854 who had complete glucose tolerance test data and the 724 newborns who provided placenta and/or cord blood samples for follow-up recruitment. Of these, 695 mother-child dyads agreed to be contacted for the prospective follow-up visits. 448 and 521 mother-child dyads completed the research visits at 3 and 5 years after delivery respectively. FINDINGS TO DATE: At both visits, we collected the mother's and child's medical history, lifestyle (using validated questionnaires), sociodemographic status, anthropometric measurements, mother's blood samples, child's saliva samples and growth charts. At the 5-year-old visit, we additionally collected the mother's and child's urine and stool samples and the child's blood samples; we performed a 75 g oral glucose tolerance test in the mothers and assessed the body composition in children using dual-energy X-ray absorptiometry. Using the Gen3G rich longitudinal data set, we have enhanced the understanding of the pathophysiology and characterisation of the heterogeneity of gestational diabetes mellitus, and we have shown that gestational hyperglycaemia and insulin resistance are associated with offspring epigenetics (DNA methylation) variations in the placenta, cord blood and blood at 5 years of age, as well as with offspring anthropometric, metabolic and neurodevelopmental outcomes in early childhood. FUTURE PLANS: We are currently conducting a prospective follow-up of mothers and their children 12 years after delivery to study how prenatal and early-life metabolic factors may programme childhood adiposity and obesogenic dietary behaviours. This follow-up should be completed by the end of 2026. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY. Published by BMJ Group. FAU - Taschereau, Amelie AU - Taschereau A AUID- ORCID: 0000-0001-8046-1322 AD - Biochimie et genomique fonctionnelle, University of Sherbrooke, Sherbrooke, Quebec, Canada amelie.taschereau@usherbrooke.ca. FAU - Doyon, Myriam AU - Doyon M AD - Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada. FAU - Arguin, Melina AU - Arguin M AD - Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada. FAU - Allard, Catherine AU - Allard C AUID- ORCID: 0000-0002-8829-4984 AD - Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada. FAU - Desgagne, Veronique AU - Desgagne V AD - Biochimie et genomique fonctionnelle, University of Sherbrooke, Sherbrooke, Quebec, Canada. FAU - Cote, Anne-Marie AU - Cote AM AUID- ORCID: 0000-0002-1252-769X AD - Department of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada. FAU - Masse, Eric AU - Masse E AD - Biochimie et genomique fonctionnelle, University of Sherbrooke, Sherbrooke, Quebec, Canada. FAU - Jacques, Pierre-Etienne AU - Jacques PE AD - Department of Biology, Universite de Sherbrooke, Sherbrooke, Quebec, Canada. FAU - Perron, Patrice AU - Perron P AD - Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada. AD - Department of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada. FAU - Hivert, Marie-France AU - Hivert MF AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA. FAU - Bouchard, Luigi AU - Bouchard L AD - Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada. AD - Department of Biochemistry, Universite de Sherbrooke, Sherbrooke, Quebec, Canada. LA - eng GR - R01 HD094150/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20250322 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 RN - 0 (Blood Glucose) SB - IM MH - Humans MH - Female MH - Pregnancy MH - Prospective Studies MH - Follow-Up Studies MH - *Diabetes, Gestational/genetics MH - Adult MH - Canada/epidemiology MH - Child, Preschool MH - Infant, Newborn MH - Male MH - *Blood Glucose/metabolism MH - Glucose Tolerance Test MH - Risk Factors MH - Mothers MH - Fetal Development/genetics MH - *Prenatal Exposure Delayed Effects/genetics PMC - PMC11931902 OTO - NOTNLM OT - EPIDEMIOLOGY OT - Follow-Up Studies OT - GENETICS OT - Obesity OT - Pregnancy COIS- Competing interests: None declared. EDAT- 2025/03/24 00:29 MHDA- 2025/03/24 00:30 PMCR- 2025/03/22 CRDT- 2025/03/23 20:43 PHST- 2025/03/24 00:30 [medline] PHST- 2025/03/24 00:29 [pubmed] PHST- 2025/03/23 20:43 [entrez] PHST- 2025/03/22 00:00 [pmc-release] AID - bmjopen-2024-093434 [pii] AID - 10.1136/bmjopen-2024-093434 [doi] PST - epublish SO - BMJ Open. 2025 Mar 22;15(3):e093434. doi: 10.1136/bmjopen-2024-093434. PMID- 40122541 OWN - NLM STAT- MEDLINE DCOM- 20250323 LR - 20250529 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 3 DP - 2025 Mar 22 TI - Predictors of inadequate and excessive gestational weight gain in women: a retrospective longitudinal observational study. PG - e087589 LID - 10.1136/bmjopen-2024-087589 [doi] LID - e087589 AB - IMPORTANCE: Monitoring and predicting optimal gestational weight gain (GWG) is important for maternal and child health. However, with recommendations based on total pregnancy GWG, available tools for real-time use in pregnancy care are lacking. These tools are prioritised by the WHO to enable healthcare providers to identify, monitor and target lifestyle interventions for those at high risk of suboptimal GWG and subsequent adverse health outcomes for mothers and babies. OBJECTIVE: This study aims to identify risk factors associated with GWG and to use these to develop an antenatal risk prediction tool for use during pregnancy to guide healthcare providers and women on optimal GWG, based on early pregnancy weight gain data. DESIGN: Routine health data from the Australian Monash Health Network birthing outcome system were used to analyse GWG in women of different body mass index (BMI) categories. Using data from 10 to 15, 15-20 and 15-25 weeks of pregnancy, we predicted the probability of women gaining inadequate or excessive total GWG by term. We used multinomial logistic regression to investigate associations between US National Academy of Medicine (NAM) classifications (inadequate, sufficient and excessive GWG) and BMI, age, country of birth (COB) by region, parity, socioeconomic status and visit frequency. SETTING: We used individual patient data routinely collected during care from one of the largest antenatal health networks in Australia. PARTICIPANTS: The study included 17 397 women from 149 countries (based on the COB) of diverse socioeconomic backgrounds, with pregnancies between 2017 and 2021. EXPOSURE: Gestational weight gain. RESULTS: Overall, 31.5% gained below, 35.7% within and 32.8% above NAM GWG recommendations. Risk factors for excess GWG were higher BMI and maternal COB by region. Compared with the healthy BMI group, the overweight group has a 4.05 times higher adjusted relative risk of excess GWG (95% CI 3.37 to 4.80), and the obese group had a relative risk of 6.64 (95% CI 5.27 to 8.37). The risk prediction tool receiver operating characteristic curve was 0.81 for the 15-25 week, 0.80 for the 15-20 week and 0.69 for the 10-15 week GWG groups, with excellent performance in both discrimination and reliability. CONCLUSIONS AND RELEVANCE: From a large population of women from diverse socioeconomic backgrounds, we have identified risk factors for suboptimal GWG and developed and internally validated a risk prediction tool for attainment of recommended GWG from early pregnancy, with high performance. This tool is designed to enable clinicians to prospectively predict attainment of NAM GWG recommendations to guide risk stratification, monitoring and appropriate intervention for those at risk of suboptimal GWG. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY. Published by BMJ Group. FAU - Ranasinha, Sanjeeva AU - Ranasinha S AUID- ORCID: 0000-0003-1323-4917 AD - Monash Centre for Health Research and Implementation, Monash University, Melbourne, Victoria, Australia. AD - Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia. AD - Alfred Health, Melbourne, Victoria, Australia. FAU - Enticott, Joanne AU - Enticott J AUID- ORCID: 0000-0002-4480-5690 AD - Monash Centre for Health Research and Implementation, Monash University, Melbourne, Victoria, Australia. AD - Monash Health, Melbourne, Victoria, Australia. FAU - Harrison, Cheryce AU - Harrison C AD - Monash Centre for Health Research and Implementation, Monash University, Melbourne, Victoria, Australia. AD - Monash Health, Melbourne, Victoria, Australia. FAU - Teede, Helena J AU - Teede HJ AD - Monash Centre for Health Research and Implementation, Monash University, Melbourne, Victoria, Australia Helena.Teede@monash.edu. AD - Monash Health, Melbourne, Victoria, Australia. LA - eng PT - Journal Article PT - Observational Study DEP - 20250322 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Gestational Weight Gain MH - Adult MH - Retrospective Studies MH - Australia/epidemiology MH - Body Mass Index MH - Longitudinal Studies MH - Risk Factors MH - *Pregnancy Complications/epidemiology MH - Young Adult MH - Prenatal Care MH - Logistic Models PMC - PMC11931920 OTO - NOTNLM OT - EPIDEMIOLOGY OT - GENERAL MEDICINE (see Internal Medicine) OT - Health policy OT - Hospitals OT - Paediatric intensive & critical care OT - Public health COIS- Competing interests: None declared. EDAT- 2025/03/24 00:29 MHDA- 2025/03/24 00:30 PMCR- 2025/03/22 CRDT- 2025/03/23 20:43 PHST- 2025/03/24 00:30 [medline] PHST- 2025/03/24 00:29 [pubmed] PHST- 2025/03/23 20:43 [entrez] PHST- 2025/03/22 00:00 [pmc-release] AID - bmjopen-2024-087589 [pii] AID - 10.1136/bmjopen-2024-087589 [doi] PST - epublish SO - BMJ Open. 2025 Mar 22;15(3):e087589. doi: 10.1136/bmjopen-2024-087589. PMID- 40121430 OWN - NLM STAT- MEDLINE DCOM- 20250325 LR - 20250325 IS - 1824-7288 (Electronic) IS - 1720-8424 (Linking) VI - 51 IP - 1 DP - 2025 Mar 22 TI - Comparison of two nutritional risk screening tools in hospitalized children with Japanese encephalitis: a causal inference of clinical outcomes and implications for optimized management. PG - 87 LID - 10.1186/s13052-025-01922-y [doi] LID - 87 AB - BACKGROUND: This study used two nutritional risk screening (NRS) tools to explore the causal relationship between nutritional risk and clinical outcomes (length of hospital stay and cost), as well as clinical results (incidence of sequelae), in hospitalized children with Japanese encephalitis (JE). The goal is to screen for a more suitable nutrition risk tool for JE reveal the underlying mechanisms, accurately quantify the impact, and provide a reliable basis for optimizing clinical management and reducing the burden of the disease in affected children. METHODS: The classical Screening Tool for Risk of Nutrition in Growth Kids (STRONGkids) and Screening Tool for Assessment of Malnutrition in Pediatrics (STAMP) were utilized to evaluate the nutritional risk of the children. A heatmap analysis was conducted to investigate the correlation between variables influencing the STRONGkids score and STAMP score. Subsequently, a decision tree was employed to identify the main factors influencing the STRONGkids score and STAMP score. Finally, causal inference was employed to calculate the causal effects between the NRS score, clinical outcomes, and clinical results. RESULTS: Dysphagia was the most significant factors affecting STRONGKids scores, and the weight and height was the most significant factors affecting STAMP scores. Causal analysis revealed that for every unit increase in the severity of JE type, the STRONGkids score increased by 0.515 units, and 1.339 units for STAMP. Moreover, the presence of dysphagia led to a 1.944-unit increase in the STRONGkids score, and 1.497-unit for STAMP. Additionally, for every unit increase in the STRONGkids score, the length of hospital stay increased by 2.541 days, and hospitalization costs increased by $612.507. Similarly, for every unit increase in the STAMP score, the length of hospital stay increased by 1.571 days, and hospitalization costs increased by $425.595. CONCLUSIONS: Based on decision tree, causal analysis and the actual situation of SNI, the internal structural setup of the STAMP tool is more suitable for screening pediatric patients with JE, making it a more reasonable choice for this purpose when compared to STRONGkids. CI - (c) 2025. The Author(s). FAU - Shen, Yilei AU - Shen Y AD - School of Mathematics, Sichuan University, Chengdu, 610065, China. FAU - Xu, Lijuan AU - Xu L AD - Department of Clinical Nutrition, Children's Hospital of Chongqing Medical University, Chongqing, China. AD - National Clinical Research Center for Child Health and Disorders, Chongqing, China. AD - Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China. AD - Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China. FAU - Tan, Tian AU - Tan T AD - Department of Clinical Nutrition, Children's Hospital of Chongqing Medical University, Chongqing, China. AD - National Clinical Research Center for Child Health and Disorders, Chongqing, China. AD - Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China. AD - Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China. FAU - Cao, Wei AU - Cao W AD - Chinese Center for Disease Control and Prevention, National Institute for Nutrition and Health, Beijing, China. AD - Key Laboratory of Public Nutrition and Health, National Health Commission of the People's Republic of China, Beijing, 100050, China. FAU - Zhao, Yong AU - Zhao Y AD - Nutrition Innovation Platform-Sichuan and Chongqing, Chongqing, China. AD - Science Popularization Studio, Chongqing, China. FAU - Feng, Yue AU - Feng Y AD - Department of Clinical Nutrition, Children's Hospital of Chongqing Medical University, Chongqing, China. AD - National Clinical Research Center for Child Health and Disorders, Chongqing, China. AD - Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China. AD - Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China. FAU - Li, Xia AU - Li X AD - Department of Clinical Nutrition, Children's Hospital of Chongqing Medical University, Chongqing, China. AD - National Clinical Research Center for Child Health and Disorders, Chongqing, China. AD - Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China. AD - Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China. FAU - Liu, Yongfang AU - Liu Y AD - Department of Clinical Nutrition, Children's Hospital of Chongqing Medical University, Chongqing, China. AD - National Clinical Research Center for Child Health and Disorders, Chongqing, China. AD - Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China. AD - Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China. FAU - Luo, Yingting AU - Luo Y AD - School of Mathematics, Sichuan University, Chengdu, 610065, China. lyt83@163.com. FAU - Kong, Lin AU - Kong L AUID- ORCID: 0009-0005-1310-2385 AD - Department of Clinical Nutrition, Children's Hospital of Chongqing Medical University, Chongqing, China. bnnknn666@163.com. AD - National Clinical Research Center for Child Health and Disorders, Chongqing, China. bnnknn666@163.com. AD - Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China. bnnknn666@163.com. AD - Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China. bnnknn666@163.com. LA - eng GR - WLKFZ202408/Key Laboratory of Public Nutrition and Health, National Health Commission of the People's Republic of China/ PT - Comparative Study PT - Journal Article DEP - 20250322 PL - England TA - Ital J Pediatr JT - Italian journal of pediatrics JID - 101510759 SB - IM MH - *Nutrition Assessment MH - *Risk Assessment/methods/statistics & numerical data MH - *Encephalitis, Japanese/complications MH - Mediation Analysis MH - Decision Trees MH - *Outcome Assessment, Health Care/methods/statistics & numerical data MH - Hospitalization/statistics & numerical data MH - *Child, Hospitalized/statistics & numerical data MH - Humans MH - Male MH - Female MH - Child, Preschool MH - Child MH - *Malnutrition/diagnosis/virology MH - Reproducibility of Results MH - Correlation of Data PMC - PMC11929289 OTO - NOTNLM OT - Causal analysis OT - Children OT - Clinical outcomes OT - Decision tree (machine learning) OT - Japanese encephalitis OT - Nutritional risk COIS- Declarations. Ethics approval and consent to participate: This study has been approved by the ethics committee of our research center [Approval Number: (2022) Ethics Review (Research) No. (116)]. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/03/23 16:52 MHDA- 2025/03/23 16:53 PMCR- 2025/03/22 CRDT- 2025/03/23 00:26 PHST- 2024/12/17 00:00 [received] PHST- 2025/02/21 00:00 [accepted] PHST- 2025/03/23 16:53 [medline] PHST- 2025/03/23 16:52 [pubmed] PHST- 2025/03/23 00:26 [entrez] PHST- 2025/03/22 00:00 [pmc-release] AID - 10.1186/s13052-025-01922-y [pii] AID - 1922 [pii] AID - 10.1186/s13052-025-01922-y [doi] PST - epublish SO - Ital J Pediatr. 2025 Mar 22;51(1):87. doi: 10.1186/s13052-025-01922-y. PMID- 40119636 OWN - NLM STAT- MEDLINE DCOM- 20251127 LR - 20260901 IS - 1464-5165 (Electronic) IS - 0963-8288 (Linking) VI - 47 IP - 24 DP - 2025 Dec TI - Evaluating the impact of school-based rebound therapy on chest health in children and young people with neurodisability and respiratory issues: a series of single case studies. PG - 6384-6395 LID - 10.1080/09638288.2025.2479080 [doi] AB - PURPOSE: To evaluate feasibility and impact of an individualised rebound therapy programme on chest health in children with complex neurodisability. METHODS AND MATERIALS: A single-case ABA design was conducted over 18 weeks with five children aged 5-15 years with complex neurodisability. Intervention involved twice weekly rebound therapy for six consecutive weeks in school. Summary outcomes included parent/carer-reported chest health, quality-of-life and clinician-observed motor ability. Serial weekly outcomes included chest health observations, usual care changes, adherence and adverse events. Parents completed a semi-structured interview after follow-up. Quantitative data were analysed descriptively and qualitative data were analysed using thematic analysis. RESULTS: Within-case and across-case findings indicated improvement in motor ability following rebound therapy intervention. Additional trends of improvement were noted in parent/carer-reported chest health and quality-of-life, but these changes were not specific to the intervention phase. Improvements in motor ability, chest health and quality-of-life indicators were verified through qualitative interview data. CONCLUSION: Co-design successfully informed an inclusive, feasible intervention study for children with complex neurodisability. However, overall improvement in parent/carer-reported chest health, quality-of-life and observed motor ability were not limited to the intervention phase. Measurement tools lacked published thresholds to determine if changes were clinically significant. FAU - Knight Lozano, Rachel AU - Knight Lozano R AUID- ORCID: 0000-0003-3672-3924 AD - School of Health Professions, Faculty of Health, University of Plymouth, Plymouth, UK. FAU - Shannon, Harriet AU - Shannon H AD - Great Ormond Street Institute of Child Health, University College London, London, UK. FAU - Bell, Kayleigh AU - Bell K AD - PenCRU Family Faculty, Parent Carer Advisory Group, Exeter, UK. FAU - Melluish, Julia AU - Melluish J AD - PenCRU Family Faculty, Parent Carer Advisory Group, Exeter, UK. FAU - Morris, Christopher AU - Morris C AUID- ORCID: 0000-0002-9916-507X AD - University of Exeter Medical School, University of Exeter, Exeter UK. FAU - Rapson, Rachel AU - Rapson R AD - Torbay and South Devon NHS Trust, Torquay, UK. FAU - Marsden, Jonathan AU - Marsden J AD - School of Health Professions, Faculty of Health, University of Plymouth, Plymouth, UK. LA - eng PT - Journal Article DEP - 20250322 PL - England TA - Disabil Rehabil JT - Disability and rehabilitation JID - 9207179 SB - IM MH - Humans MH - Child MH - Adolescent MH - Male MH - Female MH - Quality of Life MH - Child, Preschool MH - Feasibility Studies MH - Parents MH - *School Health Services MH - *Children with Disabilities/rehabilitation MH - Treatment Outcome OAB - Rebound therapy is a feasible school-based intervention to promote rehabilitation through physical activity participation in children with complex neurodisability.Selected outcome measures require further psychometric testing to evaluate the impact of this rehabilitation approach effectively.Chest health education, monitoring and communication alongside rebound therapy may positively influence outcomes of rehabilitation, such as quality of life.Co-design and safety monitoring is necessary to address challenges of implementing rehabilitation research in children with complex neurodisability. OABL- eng OTO - NOTNLM OT - Cerebral palsy OT - chest health OT - children OT - motor function OT - quality of life OT - rebound therapy OT - respiratory health EDAT- 2025/03/22 20:46 MHDA- 2025/11/27 12:29 CRDT- 2025/03/22 04:13 PHST- 2025/11/27 12:29 [medline] PHST- 2025/03/22 20:46 [pubmed] PHST- 2025/03/22 04:13 [entrez] AID - 10.1080/09638288.2025.2479080 [doi] PST - ppublish SO - Disabil Rehabil. 2025 Dec;47(24):6384-6395. doi: 10.1080/09638288.2025.2479080. Epub 2025 Mar 22. PMID- 40119462 OWN - NLM STAT- MEDLINE DCOM- 20250514 LR - 20250514 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 13 IP - 1 DP - 2025 Mar 21 TI - How does physical exercise influence self-efficacy in adolescents? A study based on the mediating role of psychological resilience. PG - 285 LID - 10.1186/s40359-025-02529-y [doi] LID - 285 AB - OBJECTIVE: This study explores the influence of physical exercise on self-efficacy in adolescents, focusing on the mediating role of psychological resilience. By analyzing direct and indirect pathways, the study provides insights into the psychological mechanisms linking physical activity and self-efficacy. METHOD: Data were collected from 1,613 adolescent participants across 15 provinces in China using validated questionnaires to measure physical exercise, psychological resilience, and self-efficacy. Structural equation modeling (SEM) was used to test direct and mediated effects, while multi-group invariance testing examined gender differences. RESULTS: Physical exercise significantly predicts both psychological resilience (beta = 0.410, p < 0.001) and self-efficacy (beta = 0.220, p < 0.001). Psychological resilience positively predicts self-efficacy (beta = 0.417, p < 0.001). Mediation analysis revealed that psychological resilience partially mediates the relationship between physical exercise and self-efficacy, contributing 43.85% to the total effect. Multi-group analysis confirmed structural invariance across genders. CONCLUSION: Physical exercise enhances adolescents' self-efficacy both directly and indirectly through psychological resilience. It strengthens psychological resilience, which in turn boosts self-efficacy. These findings highlight the key role of physical activity in promoting resilience and building adolescents' confidence in their abilities. CI - (c) 2025. The Author(s). FAU - Peng, Bo AU - Peng B AD - Sports training academy, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Chen, Weisong AU - Chen W AD - Sports training academy, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Wang, Hongshen AU - Wang H AD - Sports training academy, Chengdu Sport University, Chengdu, Sichuan, China. hongshen1101@163.com. FAU - Yu, Ting AU - Yu T AD - Jingshan Primary School, Changshou, Chongqing, China. LA - eng PT - Journal Article DEP - 20250321 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - *Self Efficacy MH - Adolescent MH - Male MH - Female MH - *Exercise/psychology MH - *Resilience, Psychological MH - China MH - Surveys and Questionnaires MH - *Adolescent Behavior/psychology PMC - PMC11927186 OTO - NOTNLM OT - Adolescents OT - Physical exercise OT - Psychological resilience OT - Self-efficacy OT - Structural equation modeling COIS- Declarations. Ethics approval and consent to participate: This study strictly adhered to the declaration of helsinki and relevant national and institutional ethical guidelines. The research protocol was reviewed and approved by the Ethics Committee of the School of Sports Training at Chengdu Sport University (Approval Number: CTYLL2024007).Since all participants were minors, dual consent was required before participation: oral informed consent from the students themselves and written consent from their parents or guardians. In some cases where logistical or access limitations made it impossible to obtain written parental consent directly, the ethics committee approved waivers based on specific circumstances, ensuring that the study adhered to ethical standards. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/03/22 20:46 MHDA- 2025/03/22 20:47 PMCR- 2025/03/21 CRDT- 2025/03/22 00:44 PHST- 2024/11/25 00:00 [received] PHST- 2025/02/21 00:00 [accepted] PHST- 2025/03/22 20:47 [medline] PHST- 2025/03/22 20:46 [pubmed] PHST- 2025/03/22 00:44 [entrez] PHST- 2025/03/21 00:00 [pmc-release] AID - 10.1186/s40359-025-02529-y [pii] AID - 2529 [pii] AID - 10.1186/s40359-025-02529-y [doi] PST - epublish SO - BMC Psychol. 2025 Mar 21;13(1):285. doi: 10.1186/s40359-025-02529-y. PMID- 40119361 OWN - NLM STAT- MEDLINE DCOM- 20250514 LR - 20250514 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Mar 21 TI - Parental neighbourhood perceptions and active commuting to school in children according to their sex using a self-organised map approach: a cross-sectional study. PG - 1089 LID - 10.1186/s12889-025-22309-y [doi] LID - 1089 AB - BACKGROUND: Built environment attributes can facilitate or represent barriers to active commuting to and from school (ACS). Even though parental perceptions of the built environment and their influence on ACS in children have been extensively studied, there is very limited evidence as to whether these perceptions can vary based on the sex of children. Hence, the present study aimed to analyse the relationships between parental neighbourhood perceptions and ACS, differentiating between boys and girls. METHODS: This cross-sectional study was conducted in Valencia, Spain. The sample comprised 808 children and one of their parents. Parent-perceived neighbourhood environment, ACS, and socio-demographic data were self-reported through a questionnaire using validated scales. Self-organising map (SOM) analysis was used to describe the interrelationships between parental perceptions and child profiles. These analyses were carried out separately in boys and girls. RESULTS: Parents of daughters perceived their neighbourhoods as less safe from crime compared to parents of sons. The number of ACS trips was similar between boys and girls. The clustering of the SOM outcomes resulted in seven clusters, both in boys and girls. However, cluster membership had significant effects on ACS in boys, but not in girls. Globally, in the group of boys, the highest ACS levels were positively correlated with the most supportive built environments in terms of residential density, land use mix, recreational facilities, accessibility and walking facilities, traffic safety, pedestrian infrastructure, safety from crime, and aesthetics. However, some of these factors had low scores in clusters with high ACS levels (e.g., low levels of accessibility and walking facilities, and land use mix). CONCLUSIONS: These findings support the idea that ACS behaviour depends on the interaction of diverse built environment factors. Our results also suggest that parental perceptions had different effects according to the sex of the child, with ACS in boys being more influenced by these perceptions. In the case of girls, it is possible that ACS interventions should emphasise generating child-friendly social environments in addition to strategies to improve the built environment. Future interventions to encourage ACS should consider these sex-specific differences and address parental concerns through improved infrastructure and safety measures. CI - (c) 2025. The Author(s). FAU - Molina-Garcia, Javier AU - Molina-Garcia J AD - AFIPS Research Group, Department of Teaching of Physical Education, Arts and Music, University of Valencia, Avda. dels Tarongers, 4, 46022, Valencia, Spain. javier.molina@uv.es. AD - Epidemiology and Environmental Health Joint Research Unit, FISABIO-UJI-UV, Valencia, Spain. javier.molina@uv.es. FAU - Garcia-Masso, Xavier AU - Garcia-Masso X AD - AFIPS Research Group, Department of Teaching of Physical Education, Arts and Music, University of Valencia, Avda. dels Tarongers, 4, 46022, Valencia, Spain. FAU - Menescardi, Cristina AU - Menescardi C AD - AFIPS Research Group, Department of Teaching of Physical Education, Arts and Music, University of Valencia, Avda. dels Tarongers, 4, 46022, Valencia, Spain. FAU - Estevan, Isaac AU - Estevan I AD - AFIPS Research Group, Department of Teaching of Physical Education, Arts and Music, University of Valencia, Avda. dels Tarongers, 4, 46022, Valencia, Spain. FAU - Queralt, Ana AU - Queralt A AD - Epidemiology and Environmental Health Joint Research Unit, FISABIO-UJI-UV, Valencia, Spain. AD - AFIPS Research Group, Department of Nursing, University of Valencia, Jaume Roig, s/n, 46010, Valencia, Spain. LA - eng GR - AICO/2022/185/Generalitat Valenciana/ GR - PID2020-115075RA-I00 by the MCIN/AEI/10.13039/50110001/Spanish National Research Agency/ GR - CAS19/00194/Spanish Ministry of Science, Innovation and Universities/ PT - Journal Article DEP - 20250321 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Female MH - *Parents/psychology MH - *Transportation/statistics & numerical data/methods MH - Child MH - Spain MH - *Schools MH - Sex Factors MH - *Built Environment MH - *Neighborhood Characteristics MH - Surveys and Questionnaires MH - Walking MH - Adult MH - Environment Design MH - *Residence Characteristics PMC - PMC11929284 OTO - NOTNLM OT - Active transport OT - Built environment OT - Ecological models OT - Girl OT - Person-centred analysis OT - Physical environment OT - Safety OT - School travel OT - Walkability OT - Walking COIS- Declarations. Ethics approval and consent to participate: The present study was conducted in accordance with the guidelines proposed in the Declaration of Helsinki and was reviewed and approved by the Ethics Committee on Human Research at the University of Valencia (registration number: H1424684423064). Written informed consent was obtained from all parents or guardians of the children involved in the study. Participation in the study was fully voluntary and anonymous with no explicit incentives provided for participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/03/22 20:46 MHDA- 2025/03/22 20:47 PMCR- 2025/03/21 CRDT- 2025/03/22 00:39 PHST- 2025/01/08 00:00 [received] PHST- 2025/03/12 00:00 [accepted] PHST- 2025/03/22 20:47 [medline] PHST- 2025/03/22 20:46 [pubmed] PHST- 2025/03/22 00:39 [entrez] PHST- 2025/03/21 00:00 [pmc-release] AID - 10.1186/s12889-025-22309-y [pii] AID - 22309 [pii] AID - 10.1186/s12889-025-22309-y [doi] PST - epublish SO - BMC Public Health. 2025 Mar 21;25(1):1089. doi: 10.1186/s12889-025-22309-y. PMID- 40116547 OWN - NLM STAT- MEDLINE DCOM- 20250321 LR - 20250514 IS - 1802-9973 (Electronic) IS - 0862-8408 (Print) IS - 0862-8408 (Linking) VI - 74 IP - 1 DP - 2025 Mar 21 TI - Exploring the Asthma - Obesity Link Using Advanced Imaging Techniques. PG - 19-29 AB - The global rise in obesity has emerged as a significant health concern, amplifying susceptibility to various diseases, including asthma. Epidemiological evidence demonstrates a higher prevalence of asthma among obese individuals, with obesity exacerbating asthma severity and control. This review aims to explore the interplay between asthma and obesity assessed by objective imaging methods and discusses the consistency between anthropometric and imaging methods. A literature search was conducted with the main keywords "asthma", "obesity", and "imaging techniques" using databases such as PubMed, Web of Sciences, and Scopus for the relevant articles published up to January 2024. The consistency between Body Mass Index (BMI), Waist Circumference (WC), and results from imaging techniques is uncertain. Unlike anthropometric methods, imaging methods provide us with the exact location of adipose tissue as well as fat and lean mass distinction, which can be further correlated with different airway parameters and respiratory system functions and dysfunctions. Studies indicate that the relationship between lung functions and obesity is more complex in females. Abdominal visceral fat is supposed to be the major asthma predictor already in the pediatric population. The connection between obesity and asthma is already evident in children and adolescents. Imaging methods can measure visceral and subcutaneous fat mass and both contribute to the association between obesity and lung functions. These methods are more accurate and reproducible but require more time and expertise. Key words Asthma, Obesity, Magnetic resonance imaging, Dual-energy, X-ray absorptiometry, Bioimpedance analysis. FAU - Krivosova, M AU - Krivosova M AD - Department of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic. daniela.mokra@uniba.sk. FAU - Barosova, R AU - Barosova R FAU - Lukacova, E AU - Lukacova E FAU - Hanusrichterova, J AU - Hanusrichterova J FAU - Nemcova, N AU - Nemcova N FAU - Kolomaznik, M AU - Kolomaznik M FAU - Mokry, J AU - Mokry J FAU - Mokra, D AU - Mokra D LA - eng PT - Journal Article PT - Review PL - Czech Republic TA - Physiol Res JT - Physiological research JID - 9112413 SB - IM MH - Humans MH - *Asthma/diagnostic imaging/epidemiology/physiopathology MH - *Obesity/diagnostic imaging/epidemiology/physiopathology/complications MH - Magnetic Resonance Imaging/methods PMC - PMC11995934 COIS- Conflict of Interest: There is no conflict of interest. EDAT- 2025/03/21 19:11 MHDA- 2025/03/21 19:12 PMCR- 2025/02/01 CRDT- 2025/03/21 09:22 PHST- 2025/03/21 19:12 [medline] PHST- 2025/03/21 19:11 [pubmed] PHST- 2025/03/21 09:22 [entrez] PHST- 2025/02/01 00:00 [pmc-release] AID - 935390 [pii] AID - pr74_19 [pii] AID - 10.33549/physiolres.935390 [doi] PST - ppublish SO - Physiol Res. 2025 Mar 21;74(1):19-29. doi: 10.33549/physiolres.935390. PMID- 40113604 OWN - NLM STAT- MEDLINE DCOM- 20250321 LR - 20250514 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 30 IP - 1 DP - 2025 Mar 20 TI - The modified weight bias internalization scale: psychometric validation of three versions in a sample of university students. PG - 28 LID - 10.1007/s40519-025-01741-4 [doi] LID - 28 AB - PURPOSE: The Modified Weight Bias Internalization Scale (WBIS-M) is perhaps the most frequently used measure of internalised weight bias and has growing support for its psychometric properties. However, there is a lack of clarity regarding how many items are necessary for adequate interpretation of the WBIS-M and limited study of internalised weight bias in young adults. The aims of this study are to evaluate different versions of the WBIS-M, assessing structural and convergent validity. METHODS: The current study recruited 205 university students (aged 18-46, mean body mass index = 22.60 kg/m(2)) in the UK and examined the factor structure, reliability, and convergent validity of the WBIS-M, looking at 11-item, 10-item, and 9-item versions. RESULTS: Confirmatory factor analysis suggested that a 10-item version of the WBIS-M showed acceptable structural validity and expected correlations with relevant constructs (depression, anxiety, weight status, and eating pathology). Estimates of internal consistency reliability were high for all three versions. CONCLUSION: Given potential problems with one item, the 10-item WBIS-M presents a measure of internalised weight bias with sound psychometric properties in young adults. LEVEL OF EVIDENCE: Level III, well-designed cohort study. CI - (c) 2025. The Author(s). FAU - Jenkins, Paul E AU - Jenkins PE AUID- ORCID: 0000-0003-1673-2903 AD - School of Psychology and Clinical Language Sciences, University of Reading, Reading, RG6 6ES, UK. pej106@gmail.com. FAU - Baysen, Lacin AU - Baysen L AD - School of Psychology and Clinical Language Sciences, University of Reading, Reading, RG6 6ES, UK. LA - eng PT - Journal Article PT - Validation Study DEP - 20250320 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - *Psychometrics MH - Female MH - Male MH - Adult MH - Young Adult MH - *Students/psychology MH - Adolescent MH - Reproducibility of Results MH - Universities MH - *Body Image/psychology MH - Middle Aged MH - Surveys and Questionnaires MH - *Body Weight MH - Factor Analysis, Statistical MH - *Weight Prejudice/psychology PMC - PMC11926019 OTO - NOTNLM OT - Confirmatory factor analysis OT - Internalised weight bias OT - Measurement OT - Students OT - Validation COIS- Declarations. Ethics approval and consent to participate: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of the University of Reading (Ref: 2023-034-PJ). Informed consent: Informed consent was obtained from all individual participants included in the study, who were also aware that their data would be preserved in an anonymised form for possible re-use. Competing interests: The authors declare no competing interests. EDAT- 2025/03/21 11:16 MHDA- 2025/03/21 11:17 PMCR- 2025/03/20 CRDT- 2025/03/21 00:12 PHST- 2025/01/21 00:00 [received] PHST- 2025/03/09 00:00 [accepted] PHST- 2025/03/21 11:17 [medline] PHST- 2025/03/21 11:16 [pubmed] PHST- 2025/03/21 00:12 [entrez] PHST- 2025/03/20 00:00 [pmc-release] AID - 10.1007/s40519-025-01741-4 [pii] AID - 1741 [pii] AID - 10.1007/s40519-025-01741-4 [doi] PST - epublish SO - Eat Weight Disord. 2025 Mar 20;30(1):28. doi: 10.1007/s40519-025-01741-4. PMID- 40113171 OWN - NLM STAT- MEDLINE DCOM- 20250506 LR - 20260813 IS - 1541-6100 (Electronic) IS - 0022-3166 (Print) IS - 0022-3166 (Linking) VI - 155 IP - 5 DP - 2025 May TI - Two a Priori Dietary Indices among Young Children in the Children's Healthy Living (CHL) Trial: Validation and Association with Health Outcomes. PG - 1549-1559 LID - S0022-3166(25)00170-1 [pii] LID - 10.1016/j.tjnut.2025.03.018 [doi] AB - BACKGROUND: Children's diets affect multiple health outcomes. Dietary indices are a useful tool for quantifying the quality of the overall diet, but their performance may differ among children of different ages and in understudied populations. OBJECTIVES: This analysis aimed to validate 2 dietary indices and examine their associations with physical body measures among 2-8-y-old children of the United States-Affiliated Pacific region. METHODS: Data were collected on children (n = 2359) from 5 jurisdictions of the children's healthy living randomized control trial in independent cross-sectional cluster samples over 3-time points. Anthropometric measurements were taken, and dietary intakes were ascertained from 2 d of dietary records completed by caregivers. The Healthy Eating Index (HEI)-2020 and dietary approaches to stop hypertension (DASH) scores were calculated using a simple scoring algorithm, their construct validity and performance were evaluated, and associations with nutrient intake, body measures, and obesity status were examined using covariate-adjusted means and unconditional logistic regression. RESULTS: We observed a wide range of variation in DASH (9-38 points) and HEI-2020 (10-94.7 points), clear separation of mean component scores by quintile of the total score, and multiple dimensions for each index. Significant trends in polyunsaturated and saturated fat were observed from the lowest to the highest quintile of HEI-2020 (12% higher and 21% reduction, respectively) but not for DASH. Significant differences by quintile of DASH and HEI-2020 were found for mean body mass index z-score among 6-8-y-olds and for waist circumference among boys and 6-8-y-olds. The odds of obesity exhibited statistically significant downward trends across quintiles of HEI-2020 among all participants and in all sexes and age groups, and across quintiles of DASH among all participants, boys and 6-8-y-olds. CONCLUSIONS: We found that HEI-2020 is a better measure of dietary intake than DASH in this population of 2-8-y-old children of the United States-Affiliated Pacific region. CI - Copyright (c) 2025 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Shvetsov, Yurii B AU - Shvetsov YB AD - Cancer Center, University of Hawai'i at Manoa, Honolulu, HI, United States. Electronic address: yshvetso@cc.hawaii.edu. FAU - Yamanaka, Ashley B AU - Yamanaka AB AD - College of Tropical Agriculture and Human Resources, University of Hawai'i at Manoa, Honolulu, HI, United States. FAU - Dela Cruz, Rica AU - Dela Cruz R AD - College of Tropical Agriculture and Human Resources, University of Hawai'i at Manoa, Honolulu, HI, United States. FAU - Butel, Jean AU - Butel J AD - College of Tropical Agriculture and Human Resources, University of Hawai'i at Manoa, Honolulu, HI, United States. FAU - Hammond, Kristi AU - Hammond K AD - College of Tropical Agriculture and Human Resources, University of Hawai'i at Manoa, Honolulu, HI, United States. FAU - Aflague, Tanisha F AU - Aflague TF AD - Cooperative Extension & Outreach, University of Guam, Mangilao, Guam. FAU - Coleman, Patricia AU - Coleman P AD - Cooperative Research, Extension, and Education Services, Northern Marianas College, Saipan, Northern Mariana Islands. FAU - Shallcross, Leslie AU - Shallcross L AD - Institute of Agriculture, Natural Resources and Extension, University of Alaska, Fairbanks, AK, United States. FAU - Fleming, Travis AU - Fleming T AD - Agriculture, Community and Natural Resources Division, American Samoa Community College, Pago Pago, American Samoa. FAU - Fialkowski, Marie K AU - Fialkowski MK AD - Cancer Center, University of Hawai'i at Manoa, Honolulu, HI, United States. FAU - Wilkens, Lynne R AU - Wilkens LR AD - Cancer Center, University of Hawai'i at Manoa, Honolulu, HI, United States. FAU - Novotny, Rachel AU - Novotny R AD - College of Tropical Agriculture and Human Resources, University of Hawai'i at Manoa, Honolulu, HI, United States. LA - eng GR - P20 GM139753/GM/NIGMS NIH HHS/United States GR - P30 CA071789/CA/NCI NIH HHS/United States PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Validation Study DEP - 20250318 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - Child, Preschool MH - Cross-Sectional Studies MH - *Diet, Healthy MH - *Diet MH - United States MH - Dietary Approaches To Stop Hypertension MH - Body Mass Index PMC - PMC12121400 OTO - NOTNLM OT - anthropometry OT - children OT - diet OT - dietary index OT - obesity OT - overweight COIS- Conflict of interest LRW and RN are editorial board members for The Journal of Nutrition and played no role in the journal's evaluation of the manuscript. All other authors report no conflicts of interest. EDAT- 2025/03/21 00:22 MHDA- 2025/05/06 06:29 PMCR- 2026/03/18 CRDT- 2025/03/20 20:41 PHST- 2024/10/23 00:00 [received] PHST- 2025/02/28 00:00 [revised] PHST- 2025/03/13 00:00 [accepted] PHST- 2025/05/06 06:29 [medline] PHST- 2025/03/21 00:22 [pubmed] PHST- 2025/03/20 20:41 [entrez] PHST- 2026/03/18 00:00 [pmc-release] AID - S0022-3166(25)00170-1 [pii] AID - 10.1016/j.tjnut.2025.03.018 [doi] PST - ppublish SO - J Nutr. 2025 May;155(5):1549-1559. doi: 10.1016/j.tjnut.2025.03.018. Epub 2025 Mar 18. PMID- 40110458 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260924 IS - 0974-7052 (Print) IS - 0975-1904 (Electronic) IS - 0974-7052 (Linking) VI - 18 IP - 1 DP - 2025 Jan TI - Employability of Mothers and its Impact on Body Mass Index and Dental Caries of their Preschool Children: A Cross-sectional Study. PG - 91-99 LID - 10.5005/jp-journals-10005-3040 [doi] AB - AIM AND BACKGROUND: Employment can affect a mother's role, as working mothers may have less time to oversee oral hygiene and diet, potentially leading to higher rates of dental caries. In contrast, non-working mothers often have more time for health routines and nutritious meal preparation, resulting in better dental outcomes. MATERIALS AND METHODS: This comparative cross-sectional study evaluates body mass index (BMI), dental caries, and sugar consumption among 3-5-year-old schoolchildren with working and non-working mothers in Mysuru city. The study included 75 children of working mothers and 75 children of non-working mothers. Data on oral hygiene and sugar consumption were collected using a validated questionnaire, and clinical examinations and BMI measurements were conducted by a trained dentist. Statistical tests like Student "t" test, ANOVA, and logistic regression analysis were used. A p-value <0.05 was considered statistically significant. RESULTS: Results showed that children of working mothers had a slightly lower mean BMI (15.45 +/- 2.15) than those of non-working mothers (15.65 +/- 2.007). Children of working mothers had higher decayed, missing, and filled teeth/decayed, extracted, and filled teeth (dmft/deft) scores, indicating more dental caries. More children of working mothers were classified as normal weight or underweight (64 and 22.7%, respectively), while more children of non-working mothers were overweight (25.3%). CONCLUSION: Both groups had similar sugary snack and dairy intake rates, but children of working mothers had higher caries rates and lower BMIs, illustrating the complex impact of maternal employment on children's oral health. CLINICAL SIGNIFICANCE: This study explores how maternal employment impacts children's BMI and dental caries, highlighting connections between employment, income, nutrition, and health. Understanding these links helps develop public health interventions to improve children's health and family well-being. HOW TO CITE THIS ARTICLE: Paramasivam K, Manjunathappa TH, SampathKumar B, et al. Employability of Mothers and its Impact on Body Mass Index and Dental Caries of their Preschool Children: A Cross-sectional Study. Int J Clin Pediatr Dent 2025;18(1):91-99. CI - Copyright (c) 2025; The Author(s). FAU - Paramasivam, Karthikaa AU - Paramasivam K AUID- ORCID: 0009-0003-1512-6909 AD - Department of Public Health Dentistry, JSS Dental College and Hospital, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. FAU - Manjunathappa, Thippeswamy H AU - Manjunathappa TH AUID- ORCID: 0000-0003-0358-6521 AD - Department of Public Health Dentistry, JSS Dental College and Hospital, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. FAU - SampathKumar, Bhuvaneshwari AU - SampathKumar B AUID- ORCID: 0009-0005-7437-9660 AD - Department of Public Health Dentistry, JSS Dental College and Hospital, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. FAU - Chandrashekhar, Vaishnavi G AU - Chandrashekhar VG AUID- ORCID: 0009-0004-9505-5537 AD - Department of Public Health Dentistry, JSS Dental College and Hospital, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. LA - eng PT - Journal Article DEP - 20250214 PL - India TA - Int J Clin Pediatr Dent JT - International journal of clinical pediatric dentistry JID - 101585405 PMC - PMC11915409 OTO - NOTNLM OT - Body mass index OT - Dental caries OT - Mother's employment OT - sugar consumption COIS- Source of support: Nil Conflict of interest: NoneConflict of interest: None EDAT- 2025/03/20 06:24 MHDA- 2025/03/20 06:25 PMCR- 2025/02/01 CRDT- 2025/03/20 05:17 PHST- 2024/08/01 00:00 [received] PHST- 2024/10/05 00:00 [accepted] PHST- 2025/03/20 06:25 [medline] PHST- 2025/03/20 06:24 [pubmed] PHST- 2025/03/20 05:17 [entrez] PHST- 2025/02/01 00:00 [pmc-release] AID - 10.5005/jp-journals-10005-3040 [doi] PST - ppublish SO - Int J Clin Pediatr Dent. 2025 Jan;18(1):91-99. doi: 10.5005/jp-journals-10005-3040. Epub 2025 Feb 14. PMID- 40108664 OWN - NLM STAT- MEDLINE DCOM- 20250513 LR - 20260505 IS - 1756-994X (Electronic) IS - 1756-994X (Linking) VI - 17 IP - 1 DP - 2025 Mar 19 TI - A polygenic score for height identifies an unmeasured genetic predisposition among pediatric patients with idiopathic short stature. PG - 23 LID - 10.1186/s13073-025-01455-3 [doi] LID - 23 AB - BACKGROUND: A subset of children with short stature do not have an identified clinical explanation after extensive diagnostic evaluation. We hypothesized that a polygenic score for height (PGS(height)) could identify children with non-familial idiopathic short stature (ISS-NF) who carry a polygenic predisposition to shorter height that is not accounted for by existing measures. METHODS: We studied 534 pediatric participants in an electronic health record (EHR)-linked DNA biobank (BioVU) who had been evaluated for short stature by an endocrinologist. Participants were classified as having one of five short stature subtypes: primary growth disorders, secondary growth disorders, idiopathic short stature (ISS), which was sub-classified into familial (ISS-F) and non-familial (ISS-NF), and constitutional delay of puberty (ISS-DP). Differences in polygenic predisposition between subtypes were analyzed using a validated PGS(height) which was standardized to a standard deviation score (SDS). Adult height predictions were generated using the PGS(height) and mid-parental height (MPH). Within-child differences in height predictions were compared across subtypes. Logistic regression models and AUC analyses were used to test the ability of the PGS(height) to differentiate ISS-NF from growth disorders. The incremental improvement (DeltaAUC) of adding the PGS(height) to prediction models with MPH was also estimated. RESULTS: Among the 534 participants, 29.0% had secondary growth disorders, 24.9% had ISS-F, 20.2% had ISS-NF, 17.2% had ISS-DP, and 8.6% had primary growth disorders. Participants with ISS-NF had similar PGS(height) values to those with ISS-F (difference [Delta] in PGS(height) SDS [95% CI] = 0.19 [- 0.31 to 0.70], p = 0.75). Predicted heights generated by the PGS(height) were lower than the MPH estimate for children with ISS-NF (Delta[PGS(height) - MPH] = - 0.37 SDS; p = 3.2 x 10(-9)) but not for children with ISS-F (Delta = - 0.07; p = 0.56). Children with ISS-NF also had lower PGS(height) than children with primary growth disorders (DeltaPGS(height) = - 0.53 [- 1.03 to - 0.04], p = 0.03) and secondary growth disorders (Delta = - 0.45 [- 0.80 to - 0.10], p = 0.005). The PGS(height) improved model discrimination between ISS-NF and children with primary (DeltaAUC, + 0.07 [95% CI, 0.02 to 0.17]) and secondary growth disorders (DeltaAUC, + 0.03 [95% CI, 0.01 to 0.10]). CONCLUSIONS: Some children with ISS-NF have an unrecognized polygenic predisposition to shorter height, similar to children with ISS-F and greater than those with growth disorders. A PGS(height) could aid clinicians in identifying children with a benign, polygenic predisposition to shorter height. CI - (c) 2025. The Author(s). FAU - Shelley, John P AU - Shelley JP AD - Department of Biomedical Informatics, Vanderbilt University Medical Center, 1285 Medical Research Building IV, Nashville, TN, 37232, USA. FAU - Shi, Mingjian AU - Shi M AD - Henry M. Jackson Foundation for the Advancement of Military Medicine, Washington, DC, USA. AD - Uniformed Services University of the Health Sciences, Bethesda, MD, USA. FAU - Peterson, Josh F AU - Peterson JF AD - Department of Biomedical Informatics, Vanderbilt University Medical Center, 1285 Medical Research Building IV, Nashville, TN, 37232, USA. AD - Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. FAU - Van Driest, Sara L AU - Van Driest SL AD - All of Us Research Program, National Institutes of Health (NIH), Bethesda, MD, USA. AD - Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. FAU - Simmons, Jill H AU - Simmons JH AD - Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. FAU - Mosley, Jonathan D AU - Mosley JD AD - Department of Biomedical Informatics, Vanderbilt University Medical Center, 1285 Medical Research Building IV, Nashville, TN, 37232, USA. jonathan.d.mosley@vumc.org. AD - Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. jonathan.d.mosley@vumc.org. LA - eng GR - T32GM007347/GM/NIGMS NIH HHS/United States GR - U01HG011181/HG/NHGRI NIH HHS/United States GR - R01GM130791/GM/NIGMS NIH HHS/United States GR - T32 GM007347/GM/NIGMS NIH HHS/United States GR - T32 GM152284/GM/NIGMS NIH HHS/United States GR - U01 HG011181/HG/NHGRI NIH HHS/United States GR - R01 GM130791/GM/NIGMS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20250319 PL - England TA - Genome Med JT - Genome medicine JID - 101475844 SB - IM UOF - Res Sq. 2024 Oct 14:rs.3.rs-4921143. doi: 10.21203/rs.3.rs-4921143/v1. PMID: 39483920 MH - Humans MH - *Body Height/genetics MH - Child MH - Male MH - Female MH - *Multifactorial Inheritance MH - *Genetic Predisposition to Disease MH - *Growth Disorders/genetics/diagnosis MH - Adolescent MH - Child, Preschool MH - *Dwarfism/genetics PMC - PMC11924680 OTO - NOTNLM OT - Common genetic variation OT - Height OT - Idiopathic short stature OT - Polygenic scores OT - Short stature COIS- Declarations. Ethics approval and consent to participate: Participants were consented prior to enrollment in BioVU with parental consent obtained for pediatric participants. This study was evaluated by the Vanderbilt Institutional Review Board (IRB #180267) and determined to be non-human subjects research as data are fully deidentified. All research conformed to the principles of the Helsinki Declaration. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/03/20 06:24 MHDA- 2025/03/20 06:25 PMCR- 2025/03/19 CRDT- 2025/03/20 00:50 PHST- 2024/08/15 00:00 [received] PHST- 2025/03/11 00:00 [accepted] PHST- 2025/03/20 06:25 [medline] PHST- 2025/03/20 06:24 [pubmed] PHST- 2025/03/20 00:50 [entrez] PHST- 2025/03/19 00:00 [pmc-release] AID - 10.1186/s13073-025-01455-3 [pii] AID - 1455 [pii] AID - 10.1186/s13073-025-01455-3 [doi] PST - epublish SO - Genome Med. 2025 Mar 19;17(1):23. doi: 10.1186/s13073-025-01455-3. PMID- 40108622 OWN - NLM STAT- MEDLINE DCOM- 20250513 LR - 20250513 IS - 1471-2474 (Electronic) IS - 1471-2474 (Linking) VI - 26 IP - 1 DP - 2025 Mar 20 TI - The prevalence and surgical outcome of late diagnosed hip dysplasia in children with Prader-Willi syndrome: a retrospective study. PG - 278 LID - 10.1186/s12891-025-08470-w [doi] LID - 278 AB - BACKGROUND: Prader-Willi syndrome (PWS) is a rare disease. Hip dysplasia is an orthopedic-related disease of PWS. Limited literature exists on the prevalence, diagnosis, and surgical management of late diagnosed hip dysplasia in PWS. This study assessed the prevalence of hip dysplasia in children with PWS and evaluated the outcomes following surgical intervention of late diagnosed hip dysplasia. METHODS: A retrospective analysis was conducted on patients diagnosed with PWS at our institution from January 1, 2017 to December 31, 2021. Patient demographics were collected, the acetabular index (AI) and the central edge angle (CEA) were measured. A single fellowship-trained pediatric orthopedic surgeon determined the presence of hip dysplasia based on radiographic measurements. RESULTS: The prevalence of hip dysplasia with PWS is 33.3%. There was no significant association between prevalence and sex or genetic subtype. The mean age at the time of diagnosis was 34.4 months (6 months to 109 months). Five patients (2 right side, 3 bilateral) underwent surgical intervention at an average age of 82.4 months. The acetabular index decreased from 42.8 +/- 5.9 degrees preoperatively to 21.7 +/- 7.7 degrees postoperatively. No serious postoperative complications were reported during the follow-up. CONCLUSIONS: The present study demonstrated a higher prevalence of hip dysplasia in patients with PWS than in the general population. The prevalence does not significantly differ across sexes or genetic subtypes. While preliminary findings suggest outcomes may be comparable to those of HD without PWS, further studies with larger cohorts are required to validate these observations. CI - (c) 2025. The Author(s). FAU - Mo, Yueqiang AU - Mo Y AUID- ORCID: 0000-0002-9096-5919 AD - Department of Orthopaedics Surgery, Children's Hospital of Fudan University, Wanyuan Road 399, Minhang District, Shanghai, 201102, China. FAU - Wu, Chunxing AU - Wu C AUID- ORCID: 0000-0002-2702-5000 AD - Department of Orthopaedics Surgery, Children's Hospital of Fudan University, Wanyuan Road 399, Minhang District, Shanghai, 201102, China. FAU - Huang, Peng AU - Huang P AUID- ORCID: 0000-0001-9398-0578 AD - Department of Orthopaedics Surgery, Children's Hospital of Fudan University, Wanyuan Road 399, Minhang District, Shanghai, 201102, China. FAU - Wang, Dahui AU - Wang D AUID- ORCID: 0000-0002-3101-702X AD - Department of Orthopaedics Surgery, Children's Hospital of Fudan University, Wanyuan Road 399, Minhang District, Shanghai, 201102, China. FAU - Jing, Yanhui AU - Jing Y AUID- ORCID: 0009-0005-1381-8535 AD - Department of Orthopaedics Surgery, Children's Hospital of Fudan University, Wanyuan Road 399, Minhang District, Shanghai, 201102, China. jingyanhui2008@163.com. FAU - Ning, Bo AU - Ning B AUID- ORCID: 0000-0002-9752-2459 AD - Department of Orthopaedics Surgery, Children's Hospital of Fudan University, Wanyuan Road 399, Minhang District, Shanghai, 201102, China. ningbo@fudan.edu.cn. LA - eng GR - nos.82272441/National Natural Science Foundation of China/ GR - nos.22Y11912200/Natural Science Foundation of Shanghai Municipality/ PT - Journal Article DEP - 20250320 PL - England TA - BMC Musculoskelet Disord JT - BMC musculoskeletal disorders JID - 100968565 SB - IM MH - Humans MH - Retrospective Studies MH - Male MH - Female MH - *Prader-Willi Syndrome/complications/epidemiology MH - Prevalence MH - Child MH - Child, Preschool MH - Treatment Outcome MH - *Hip Dislocation/epidemiology/surgery/diagnostic imaging MH - Infant MH - *Delayed Diagnosis MH - Acetabulum/diagnostic imaging PMC - PMC11924822 OTO - NOTNLM OT - Hip dysplasia OT - Late diagnosed OT - Prader-Willi syndrome OT - Prevalence OT - Surgical outcome COIS- Declarations. Ethics approval and consent to participate: Our study was approved by The Ethics Committee approval of Children's hospital of Fudan University and conducted according to the Helsinki Declaration and its later amendments. Informed consent was obtained from all patients' parents who participated in this study. Consent for publication: All participants were informed about the purpose of the study and informed consent was obtained for all patient images from a parent and/or legal guardian. Clinical trial number: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/03/20 06:24 MHDA- 2025/03/20 06:25 PMCR- 2025/03/20 CRDT- 2025/03/20 00:48 PHST- 2024/12/22 00:00 [received] PHST- 2025/02/24 00:00 [accepted] PHST- 2025/03/20 06:25 [medline] PHST- 2025/03/20 06:24 [pubmed] PHST- 2025/03/20 00:48 [entrez] PHST- 2025/03/20 00:00 [pmc-release] AID - 10.1186/s12891-025-08470-w [pii] AID - 8470 [pii] AID - 10.1186/s12891-025-08470-w [doi] PST - epublish SO - BMC Musculoskelet Disord. 2025 Mar 20;26(1):278. doi: 10.1186/s12891-025-08470-w. PMID- 40108493 OWN - NLM STAT- MEDLINE DCOM- 20250514 LR - 20250514 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 25 IP - 1 DP - 2025 Mar 19 TI - Predicting low birth weight risks in pregnant women in Brazil using machine learning algorithms: data from the Araraquara cohort study. PG - 320 LID - 10.1186/s12884-025-07351-3 [doi] LID - 320 AB - BACKGROUND: Low birth weight (LBW) is a critical factor linked to neonatal morbidity and mortality. Early prediction is essential for timely interventions. This study aimed to develop and evaluate predictive models for LBW using machine learning algorithms, including Random Forest, XGBoost, Catboost, and LightGBM. METHODS: We analyzed data from 1,579 pregnant women enrolled in the Araraquara Cohort, a population-based longitudinal study. Predictor variables included maternal sociodemographic, clinical, and behavioral factors. Four ML algorithms Random Forest, XGBoost, CatBoost, and LightGBM, were trained using an 80/20 train-test split and 10-fold cross-validation. To address class imbalance, the Synthetic Minority Over-sampling Technique (SMOTE) was applied. Model performance was assessed using metrics such as area under the receiver operating characteristic curve (AUROC), F1-score, and precision-recall. Variable importance was evaluated using Shapley values. RESULTS: XGBoost demonstrated the best performance, achieving an AUROC of 0.94, followed by CatBoost (0.94), Random Forest (0.94), and LightGBM (0.94). Maternal gestational age was the most influential predictor, followed by marital status and prenatal care frequency. Behavioral factors, such as physical activity, also contributed to LBW risk. Shapley analysis provided interpretable insights into variable contributions, supporting the clinical applicability of the models. CONCLUSION: Machine learning, combined with SMOTE, proved to be an effective approach for predicting LBW. XGBoost stood out as the most accurate model, but Catboost and Random Forest also provided solid results. These models can be applied to identify high-risk pregnancies, improving perinatal outcomes through early interventions. CI - (c) 2025. The Author(s). FAU - Victor, Audencio AU - Victor A AUID- ORCID: 0000-0002-8161-3639 AD - School of Public Health, University of Sao Paulo (USP), Faculdade de Saude Publica- USP Avenida Doutor Arnaldo, 715 - Sao Paulo, Sao Paulo, 01246904, Brazil. audenciovictor@gmail.com. AD - Department of Nutrition, Ministry of Health of Mozambique, Maputo, Mozambique. audenciovictor@gmail.com. FAU - Almeida, Francielly AU - Almeida F AD - Faculdade de Economia, Administracao e Contabilidade de Ribeirao Preto, FEA-RP/USP, Ribeirao Preto, Sao Paulo, Brazil. FAU - Xavier, Sancho Pedro AU - Xavier SP AD - Institute of Collective Health, Federal University of Mato Grosso. Cuiaba, Mato Grosso, Brazil. FAU - Rondo, Patricia H C AU - Rondo PHC AD - School of Public Health, University of Sao Paulo (USP), Faculdade de Saude Publica- USP Avenida Doutor Arnaldo, 715 - Sao Paulo, Sao Paulo, 01246904, Brazil. LA - eng PT - Journal Article DEP - 20250319 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Machine Learning MH - Brazil/epidemiology MH - Adult MH - *Infant, Low Birth Weight MH - Infant, Newborn MH - Longitudinal Studies MH - Algorithms MH - Risk Assessment/methods MH - Gestational Age MH - Risk Factors MH - Young Adult MH - Cohort Studies MH - ROC Curve PMC - PMC11921654 OTO - NOTNLM OT - Araraquara cohort OT - Low birth weight OT - Machine learning OT - Random forest OT - XGBoost COIS- Declarations. Ethics approval and consent to participate: The research received ethical approval from the Research Ethics Committee with Human Subjects at the School of Public Health, University of Sao Paulo, before the commencement of data collection, as per protocol CAEE: 59787216.2.0000.5421 and opinion number 1.885.874. All participants provided informed consent, consistent with the principles outlined in the Helsinki Declaration. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/03/20 06:24 MHDA- 2025/03/20 06:25 PMCR- 2025/03/19 CRDT- 2025/03/20 00:42 PHST- 2024/11/17 00:00 [received] PHST- 2025/02/19 00:00 [accepted] PHST- 2025/03/20 06:25 [medline] PHST- 2025/03/20 06:24 [pubmed] PHST- 2025/03/20 00:42 [entrez] PHST- 2025/03/19 00:00 [pmc-release] AID - 10.1186/s12884-025-07351-3 [pii] AID - 7351 [pii] AID - 10.1186/s12884-025-07351-3 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2025 Mar 19;25(1):320. doi: 10.1186/s12884-025-07351-3. PMID- 40107454 OWN - NLM STAT- MEDLINE DCOM- 20250615 LR - 20260903 IS - 1541-6100 (Electronic) IS - 0022-3166 (Print) IS - 0022-3166 (Linking) VI - 155 IP - 6 DP - 2025 Jun TI - The Association of Prenatal Dietary Factors with Child Autism Diagnosis and Autism-Related Traits Using a Mixtures Approach: Results from the Environmental Influences on Child Health Outcomes Cohort. PG - 1938-1951 LID - S0022-3166(25)00165-8 [pii] LID - 10.1016/j.tjnut.2025.02.025 [doi] AB - BACKGROUND: Previous research on the role of maternal diet in relation to autism has focused on examining individual nutrient associations. Few studies have examined associations with multiple nutrients using mixtures approaches, which may better reflect true exposure scenarios. OBJECTIVES: This study aims to examine associations of nutrient mixtures with children's autism diagnosis and trait scores within a large, diverse population. METHODS: Participants were drawn from the United States Environmental influences on Child Health Outcomes (ECHO) consortium. Maternal prenatal diet was reported via validated food frequency questionnaires. Children's autism-related traits were measured using the Social Responsiveness Scale (SRS) and autism diagnoses were from parent reports of physician diagnosis. Bayesian kernel machine regression was used to examine the overall mixture effect and interactions between a set of 5 primary nutrients (folate, vitamin D, omega 3 and omega 6 fatty acids, and iron), adjusted for potential confounders, in relationship to child outcomes. Secondary analyses were conducted in a subset of cohorts with an expanded set of 14 nutrients. Traditional linear and logistic regression models were also analyzed for comparison of results to mixture models. RESULTS: A total of 2614 participants drawn from 7 ECHO cohorts were included in primary analysis. Mixture analyses suggested that increasing the overall 5-nutrient mixture was associated with lower SRS scores. Individual U-shaped associations and bivariate interactions between folate and omega 3 fatty acids were suggested. In the subset included in the secondary analyses of the 14-nutrient mixture, a modest inverse trend remained, but individual nutrient associations were altered, with vitamin D demonstrating higher relative importance than other nutrients. Strong associations with autism diagnosis were not observed. CONCLUSIONS: In this large sample, we found evidence for combined nutrient effects with broader autism-related traits. Because results for individual nutrients were sensitive to mixture components, replication of combined associations between nutrients and autism-related outcomes is needed. CI - Copyright (c) 2025 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Bragg, Megan G AU - Bragg MG AD - AJ Drexel Autism Institute, Drexel University, Philadelphia, PA, United States. FAU - Rando, Juliette AU - Rando J AD - AJ Drexel Autism Institute, Drexel University, Philadelphia, PA, United States. FAU - Carroll, Kecia N AU - Carroll KN AD - The Icahn School of Medicine at Mount Sinai, New York, NY, United States. FAU - Eick, Stephanie M AU - Eick SM AD - Rollins School of Public Health, Emory University, Atlanta, GA, United States. FAU - Karagas, Margaret R AU - Karagas MR AD - Geisel School of Medicine, Dartmouth College, Hanover, NH, United States. FAU - Lin, Pi-I AU - Lin PI AD - Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, United States. FAU - Schmidt, Rebecca J AU - Schmidt RJ AD - Department of Public Health Sciences, School of Medicine, University of California Davis, Davis, CA, United States. FAU - Lyall, Kristen AU - Lyall K AD - AJ Drexel Autism Institute, Drexel University, Philadelphia, PA, United States. Electronic address: kld98@drexel.edu. CN - ECHO Cohort Consortium LA - eng GR - UG3 OD035542/OD/NIH HHS/United States GR - UH3 OD023275/OD/NIH HHS/United States GR - UG3 OD035529/OD/NIH HHS/United States GR - R01 MH059630/MH/NIMH NIH HHS/United States GR - U2C OD023375/OD/NIH HHS/United States GR - UH3 OD023253/OD/NIH HHS/United States GR - UG3 OD023253/OD/NIH HHS/United States GR - UH3 OD023349/OD/NIH HHS/United States GR - UH3 OD023285/OD/NIH HHS/United States GR - UG3 OD035508/OD/NIH HHS/United States GR - UH3 OD023248/OD/NIH HHS/United States GR - UG3 OD035526/OD/NIH HHS/United States GR - P01 HD035468/HD/NICHD NIH HHS/United States GR - UG3 OD035537/OD/NIH HHS/United States GR - UH3 OD023287/OD/NIH HHS/United States GR - UG3 OD023249/OD/NIH HHS/United States GR - UH3 OD023365/OD/NIH HHS/United States GR - UH3 OD023288/OD/NIH HHS/United States GR - UH3 OD023337/OD/NIH HHS/United States GR - UH3 OD023251/OD/NIH HHS/United States GR - UG3 OD035540/OD/NIH HHS/United States GR - U24 OD023382/OD/NIH HHS/United States GR - UH3 OD023389/OD/NIH HHS/United States GR - U2C ES026542/ES/NIEHS NIH HHS/United States GR - UG3 OD023389/OD/NIH HHS/United States GR - UH3 OD023249/OD/NIH HHS/United States GR - UG3 OD035517/OD/NIH HHS/United States GR - UG3 OD035518/OD/NIH HHS/United States GR - UH3 OD023320/OD/NIH HHS/United States GR - UG3 OD023342/OD/NIH HHS/United States GR - UH3 OD023305/OD/NIH HHS/United States GR - UG3 OD035519/OD/NIH HHS/United States GR - UH3 OD023286/OD/NIH HHS/United States GR - UG3 OD023244/OD/NIH HHS/United States GR - UG3 OD035543/OD/NIH HHS/United States GR - P50 HD103538/HD/NICHD NIH HHS/United States GR - UH3 OD023272/OD/NIH HHS/United States GR - UG3 OD023290/OD/NIH HHS/United States GR - U2C ES030851/ES/NIEHS NIH HHS/United States GR - UG3 OD035509/OD/NIH HHS/United States GR - UG3 OD035528/OD/NIH HHS/United States GR - UG3 OD023288/OD/NIH HHS/United States GR - UH3 OD023290/OD/NIH HHS/United States GR - UH3 OD023342/OD/NIH HHS/United States GR - UG3 OD023251/OD/NIH HHS/United States GR - UH3 OD023332/OD/NIH HHS/United States GR - UG3 OD023305/OD/NIH HHS/United States GR - UG3 OD023313/OD/NIH HHS/United States GR - UG3 OD023275/OD/NIH HHS/United States GR - UG3 OD035532/OD/NIH HHS/United States GR - UG3 OD023349/OD/NIH HHS/United States GR - UG3 OD023337/OD/NIH HHS/United States GR - U2C ES026555/ES/NIEHS NIH HHS/United States GR - P30 ES007033/ES/NIEHS NIH HHS/United States GR - UH3 OD023318/OD/NIH HHS/United States GR - UH3 OD023347/OD/NIH HHS/United States GR - U24 OD035523/OD/NIH HHS/United States GR - UG3 OD035546/OD/NIH HHS/United States GR - UG3 OD023279/OD/NIH HHS/United States GR - UG3 OD023344/OD/NIH HHS/United States GR - UG3 OD035521/OD/NIH HHS/United States GR - UG3 OD023285/OD/NIH HHS/United States GR - U2C ES026561/ES/NIEHS NIH HHS/United States GR - UH3 OD023279/OD/NIH HHS/United States GR - UG3 OD023289/OD/NIH HHS/United States GR - UH3 OD023268/OD/NIH HHS/United States GR - UG3 OD035550/OD/NIH HHS/United States GR - UH3 OD035516/OD/NIH HHS/United States GR - UH3 OD023348/OD/NIH HHS/United States GR - UG3 OD035527/OD/NIH HHS/United States GR - UH3 OD023282/OD/NIH HHS/United States GR - U2C ES030857/ES/NIEHS NIH HHS/United States GR - UG3 OD023282/OD/NIH HHS/United States GR - UG3 OD035516/OD/NIH HHS/United States GR - UH3 OD023271/OD/NIH HHS/United States GR - UG3 OD023348/OD/NIH HHS/United States GR - UG3 OD035544/OD/NIH HHS/United States GR - UH3 OD023244/OD/NIH HHS/United States GR - U2C ES030859/ES/NIEHS NIH HHS/United States GR - UG3 OD023272/OD/NIH HHS/United States GR - UG3 OD023248/OD/NIH HHS/United States GR - UG3 OD035536/OD/NIH HHS/United States GR - UH3 OD023328/OD/NIH HHS/United States GR - UG3 OD035513/OD/NIH HHS/United States GR - U2C ES026533/ES/NIEHS NIH HHS/United States GR - UH3 OD023289/OD/NIH HHS/United States GR - UH3 OD035536/OD/NIH HHS/United States GR - U24 OD023319/OD/NIH HHS/United States GR - UH3 OD035550/OD/NIH HHS/United States GR - UH3 OD023313/OD/NIH HHS/United States GR - UG3 OD035533/OD/NIH HHS/United States GR - UG3 OD023365/OD/NIH HHS/United States GR - U24 ES026539/ES/NIEHS NIH HHS/United States GR - UH3 OD023344/OD/NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20250317 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 RN - 935E97BOY8 (Folic Acid) SB - IM MH - Humans MH - Female MH - *Autistic Disorder/diagnosis/etiology/epidemiology MH - Pregnancy MH - Male MH - *Diet MH - Child MH - Cohort Studies MH - Child, Preschool MH - Adult MH - Folic Acid/administration & dosage MH - Child Health MH - *Maternal Nutritional Physiological Phenomena MH - United States PMC - PMC12264552 OTO - NOTNLM OT - autism OT - epidemiology OT - neurodevelopment OT - nutrients OT - statistical mixtures methods COIS- Conflict of interest The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors report no conflicts of interest. FIR - Smith, P Brian IR - Smith PB IRAD- Division of Neonatology, Department of Pediatrics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA. FIR - Newby, L Kristin IR - Newby LK IRAD- Division of Cardiology, Department of Medicine, Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA. FIR - Adair, Linda IR - Adair L IRAD- Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FIR - Jacobson, Lisa P IR - Jacobson LP IRAD- Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, USA. FIR - Catellier, Diane IR - Catellier D IRAD- N/A, Research Triangle Institute, Research Triangle Park, North Carolina, USA. FIR - McGrath, Monica IR - McGrath M IRAD- Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, USA. FIR - Douglas, Christian IR - Douglas C IRAD- N/A, Research Triangle Institute, Research Triangle Park, North Carolina, USA. FIR - Duggal, Priya IR - Duggal P IRAD- Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, USA. FIR - Knapp, Emily IR - Knapp E IRAD- Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, USA. FIR - Kress, Amii IR - Kress A IRAD- Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, USA. FIR - Blackwell, Courtney K IR - Blackwell CK IRAD- Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. FIR - Mansolf, Maxwell A IR - Mansolf MA IRAD- Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. FIR - Lai, Jin-Shei IR - Lai JS IRAD- Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. FIR - Ho, Emily IR - Ho E IRAD- Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. FIR - Cella, David IR - Cella D IRAD- Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. FIR - Gershon, Richard IR - Gershon R IRAD- Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. FIR - Macy, Michelle L IR - Macy ML IRAD- Department of Pediatrics, Feinberg School of Medicine, Northwestern University and Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA. FIR - Das, Suman R IR - Das SR IRAD- Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FIR - Freedman, Jane E IR - Freedman JE IRAD- Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FIR - Mallal, Simon A IR - Mallal SA IRAD- Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FIR - McLean, John A IR - McLean JA IRAD- Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA. FIR - Shah, Ravi V IR - Shah RV IRAD- Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FIR - Shilts, Meghan H IR - Shilts MH IRAD- Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FIR - Alshawabkeh, Akram N IR - Alshawabkeh AN IRAD- College of Engineering, Northeastern University, Boston, Massachusetts, USA. FIR - Cordero, Jose F IR - Cordero JF IRAD- College of Public Health, Department of Epidemiology & Biostatistics, University of Georgia, Athens, Georgia, USA. FIR - Meeker, John IR - Meeker J IRAD- Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA. FIR - Trasande, Leonardo IR - Trasande L IRAD- Departments of Pediatrics and Population Health, NYU Grossman School of Medicine, New York, New York, USA. FIR - Camargo, Carlos A IR - Camargo CA IRAD- Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. FIR - Zhu, Zhaozhong IR - Zhu Z IRAD- Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. FIR - Sullivan, Ashley F IR - Sullivan AF IRAD- Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. FIR - Dabelea, Dana IR - Dabelea D IRAD- Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FIR - Perng, Wei IR - Perng W IRAD- Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FIR - Bekelman, Traci A IR - Bekelman TA IRAD- Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FIR - Wilkening, Greta IR - Wilkening G IRAD- Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FIR - Magzamen, Sheryl IR - Magzamen S IRAD- Environmental and Radiological Health Sciences, Colorado School of Public Health, Colorado State University, Fort Collins, Colorado, USA. FIR - Moore, Brianna F IR - Moore BF IRAD- Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FIR - Starling, Anne P IR - Starling AP IRAD- Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FIR - Rinehart, Deborah J IR - Rinehart DJ IRAD- Center for Health Systems Research, Denver Health and Hospital Authority, Denver, Colorado, USA. FIR - Mitchell, Daphne Koinis IR - Mitchell DK IRAD- Department of Pediatrics, Rhode Island Hospital, The Alpert Medical School of Brown University, Providence, Rhode Island, USA. FIR - D'Sa, Viren IR - D'Sa V IRAD- Department of Pediatrics, Rhode Island Hospital, The Alpert Medical School of Brown University, Providence, Rhode Island, USA. FIR - Deoni, Sean Cl IR - Deoni SC IRAD- Division of Gender Equality, Maternal, Newborn & Child Health Discovery & Tools Team, Bill & Melinda Gates Foundation, Seattle, Washington, USA. FIR - Mueller, Hans-Georg IR - Mueller HG IRAD- Department of Statistics, University of California, Davis, Davis, California, USA. FIR - Duarte, Cristiane S IR - Duarte CS IRAD- Division of Child and Adolescent Psychiatry, Columbia University - NYSPI, New York, New York, USA. FIR - Monk, Catherine IR - Monk C IRAD- Department of Obstetrics & Gynecology, Columbia University - NYSPI, New York, New York, USA. FIR - Canino, Glorisa IR - Canino G IRAD- Behavioral Sciences Research Institute, University of Puerto Rico, School of Medicine, Rio Piedras, Puerto Rico. FIR - Posner, Jonathan IR - Posner J IRAD- Child & Family Mental Health & Community Psychiatry Division, Duke University School of Medicine, Duke Psychiatry & Behavioral Sciences, Durham, North Carolina, USA. FIR - Murray, Tenneill IR - Murray T IRAD- Division of Child and Adolescent Psychiatry, Columbia University - NYSPI, New York, New York, USA. FIR - Lugo-Candelas, Claudia IR - Lugo-Candelas C IRAD- Division of Child and Adolescent Psychiatry, Columbia University - NYSPI, New York, New York, USA. FIR - Dunlop, Anne L IR - Dunlop AL IRAD- Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia, USA. FIR - Brennan, Patricia A IR - Brennan PA IRAD- Department of Psychology, Emory University, Atlanta, Georgia, USA. FIR - Hockett, Christine IR - Hockett C IRAD- N/A, Department of Pediatrics, Avera Research Institute, University of South Dakota School of Medicine, Rapid City, South Dakota, USA; N/A, Department of Pediatrics, Avera Research Institute, University of South Dakota School of Medicine, Sioux Falls, South Dakota, USA. FIR - Elliott, Amy IR - Elliott A IRAD- N/A, Department of Pediatrics, Avera Research Institute, University of South Dakota School of Medicine, Sioux Falls, South Dakota, USA. FIR - Ferrara, Assiamira IR - Ferrara A IRAD- Division of Research, Kaiser Permanente Northern California, Oakland, California, USA. FIR - Croen, Lisa A IR - Croen LA IRAD- Division of Research, Kaiser Permanente Northern California, Oakland, California, USA. FIR - Hedderson, Monique M IR - Hedderson MM IRAD- Division of Research, Kaiser Permanente Northern California, Oakland, California, USA. FIR - Ainsworth, John IR - Ainsworth J IRAD- Centre for Health Informatics, University of Manchester, Manchester, United Kingdom. FIR - Bacharier, Leonard B IR - Bacharier LB IRAD- Department of Pediatrics, Monroe Carell Jr Children's Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FIR - Bendixsen, Casper G IR - Bendixsen CG IRAD- National Farm Medicine Center, Marshfield Clinic Research Institute, Marshfield, Wisconsin, USA. FIR - Gern, James E IR - Gern JE IRAD- Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA. FIR - Gold, Diane R IR - Gold DR IRAD- The Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. FIR - Hartert, Tina V IR - Hartert TV IRAD- Division of Pediatric Allergy, Immunology, and Pulmonary Medicine, Department of Medicine, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FIR - Jackson, Daniel J IR - Jackson DJ IRAD- Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA. FIR - Johnson, Christine C IR - Johnson CC IRAD- Department of Public Health Sciences, Henry Ford Health, Detroit, Michigan, USA. FIR - Joseph, Christine Lm IR - Joseph CL IRAD- Department of Public Health Sciences, Henry Ford Health, Detroit, Michigan, USA. FIR - Kattan, Meyer IR - Kattan M IRAD- Department of Pediatrics, Columbia University Medical Center, New York, New York, USA. FIR - Khurana Hershey, Gurjit K IR - Khurana Hershey GK IRAD- Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. FIR - Lemanske, Robert F IR - Lemanske RF IRAD- Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA. FIR - Lynch, Susan V IR - Lynch SV IRAD- Department of Medicine, University of California, San Francisco, California, USA. FIR - Miller, Rachel L IR - Miller RL IRAD- Department of Medicine, Division of Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. FIR - O'Connor, George T IR - O'Connor GT IRAD- Department of Pediatrics, Boston University School of Medicine, Boston, Massachusetts, USA. FIR - Ober, Carole IR - Ober C IRAD- Department of Human Genetics, University of Chicago, Chicago, Illinois, USA. FIR - Ownby, Dennis IR - Ownby D IRAD- Department of Public Health Sciences, Henry Ford Health, Detroit, Michigan, USA. FIR - Rivera-Spoljaric, Katherine IR - Rivera-Spoljaric K IRAD- Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA. FIR - Ryan, Patrick H IR - Ryan PH IRAD- Department of Pediatrics and College of Medicine, Division of Biostatistics and Epidemiology, University of Cincinnati, Cincinnati, Ohio, USA. FIR - Seroogy, Christine M IR - Seroogy CM IRAD- Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA. FIR - Singh, Anne Marie IR - Singh AM IRAD- Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA. FIR - Wood, Robert A IR - Wood RA IRAD- Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. FIR - Zoratti, Edward M IR - Zoratti EM IRAD- Division of Allergy and Clinical Immunology, Henry Ford Health, Detroit, Michigan, USA. FIR - Habre, Rima IR - Habre R IRAD- Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA. FIR - Farzan, Shohreh IR - Farzan S IRAD- Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA. FIR - Gilliland, Frank D IR - Gilliland FD IRAD- Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA. FIR - Hertz-Picciotto, Irva IR - Hertz-Picciotto I IRAD- MIND Institute and Department of Public Health Sciences, University of California, Davis, Davis, California, USA. FIR - Bennett, Deborah H IR - Bennett DH IRAD- Department of Public Health Sciences, University of California, Davis, Davis, California, USA. FIR - Schweitzer, Julie B IR - Schweitzer JB IRAD- Department of Psychiatry and Behavioral Science and the MIND Institute, University of California, Davis, Davis, California, USA. FIR - Schmidt, Rebecca J IR - Schmidt RJ IRAD- MIND Institute and Department of Public Health Sciences, University of California, Davis, Davis, California, USA. FIR - LaSalle, Janine M IR - LaSalle JM IRAD- Department of Public Health Sciences, University of California, Davis, Davis, California, USA. FIR - Hipwell, Alison E IR - Hipwell AE IRAD- Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. FIR - Keenan, Kate E IR - Keenan KE IRAD- Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA. FIR - Karr, Catherine J IR - Karr CJ IRAD- Department of Pediatrics, School of Medicine, Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, Washington, USA. FIR - Bush, Nicole R IR - Bush NR IRAD- Department of Psychiatry and Behavioral Sciences and Department of Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, California, USA. FIR - LeWinn, Kaja Z IR - LeWinn KZ IRAD- Department of Psychiatry and Behavioral Sciences, School of Medicine, University of California, San Francisco, San Francisco, California, USA. FIR - Sathyanarayana, Sheela IR - Sathyanarayana S IRAD- Department of Pediatrics, School of Medicine, Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington and Seattle Children's Research Institute, Seattle, Washington, USA. FIR - Zhao, Qi IR - Zhao Q IRAD- Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA. FIR - Tylavsky, Frances IR - Tylavsky F IRAD- Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA. FIR - Carroll, Kecia N IR - Carroll KN IRAD- Department of Pediatrics, Department of Environmental Medicine & Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA. FIR - Loftus, Christine T IR - Loftus CT IRAD- Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, Washington, USA. FIR - Leve, Leslie D IR - Leve LD IRAD- Department of Counseling Psychology and Human Services & Prevention Science Institute, University of Oregon, Eugene, Oregon, USA. FIR - Ganiban, Jody M IR - Ganiban JM IRAD- Department of Psychological and Behavioral Sciences, George Washington University, Washington, DC, USA. FIR - Neiderhiser, Jenae M IR - Neiderhiser JM IRAD- Department of Psychology, Penn State University, University Park, Pennsylvania, USA. FIR - Weiss, Scott T IR - Weiss ST IRAD- Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. FIR - Litonjua, Augusto A IR - Litonjua AA IRAD- Pediatric Pulmonary Division, Department of Pediatrics, Golisano Children's Hospital, University of Rochester, Rochester, New York, USA. FIR - McEvoy, Cindy T IR - McEvoy CT IRAD- Division of Neonatology, Department of Pediatrics, Oregon Health & Science University, Portland, Oregon, USA. FIR - Spindel, Eliot R IR - Spindel ER IRAD- Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon, USA. FIR - Tepper, Robert S IR - Tepper RS IRAD- Division of Pediatric Pulmonology, Department of Pediatrics, Indiana School of Medicine, Indianapolis, Indiana, USA. FIR - Newschaffer, Craig J IR - Newschaffer CJ IRAD- College of Health and Human Development, Penn State, State College, Pennsylvania, USA. FIR - Lyall, Kristen IR - Lyall K IRAD- AJ Drexel Autism Institute, Drexel University, Philadelphia, Pennsylvania, USA. FIR - Volk, Heather E IR - Volk HE IRAD- Mental Health, Johns Hopkins University, Baltimore, Maryland, USA. FIR - Landa, Rebecca IR - Landa R IRAD- Department of Psychiatry and Behavioral Sciences, Center for Autism and Related Disorders, Kennedy Krieger Institute, Johns Hopkins University, Baltimore, Maryland, USA. FIR - Ozonoff, Sally IR - Ozonoff S IRAD- MIND Institute, Department of Psychiatry, University of California Davis, Sacramento, California, USA. FIR - Piven, Joseph IR - Piven J IRAD- Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA. FIR - Hazlett, Heather IR - Hazlett H IRAD- Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA. FIR - Pandey, Juhi IR - Pandey J IRAD- Center for Autism Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FIR - Schultz, Robert IR - Schultz R IRAD- Center for Autism Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FIR - Dager, Steven IR - Dager S IRAD- Department of Radiology, University of Washington, Seattle, Washington, USA. FIR - Botteron, Kelly IR - Botteron K IRAD- Department of Psychiatry, Washington University, St Louis, Missouri, USA. FIR - Messinger, Daniel IR - Messinger D IRAD- Department of Psychology, University of Miami, Miami, Florida, USA. FIR - Stone, Wendy IR - Stone W IRAD- Department of Psychology, University of Washington, Seattle, Washington, USA. FIR - Ames, Jennifer IR - Ames J IRAD- Kaiser Permanente Division of Research, Kaiser Permanente, Oakland, California, USA. FIR - O'Connor, Thomas G IR - O'Connor TG IRAD- Departments of Psychiatry, Neuroscience, Obstetrics and Gynecology, University of Rochester, Rochester, New York, USA. FIR - Miller, Richard K IR - Miller RK IRAD- Departments of Obstetrics and Gynecology, University of Rochester, Rochester, New York, USA. FIR - Oken, Emily IR - Oken E IRAD- Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, Massachusetts, USA. FIR - Hacker, Michele R IR - Hacker MR IRAD- Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. FIR - James-Todd, Tamarra IR - James-Todd T IRAD- Department of Environmental Health, Harvard Chan School of Public Health, Boston, Massachusetts, USA. FIR - O'Shea, T Michael IR - O'Shea TM IRAD- Division of Neonatology, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA. FIR - Fry, Rebecca C IR - Fry RC IRAD- Department of Environmental Sciences and Engineering, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina, USA. FIR - Frazier, Jean A IR - Frazier JA IRAD- EK Shriver Center and Psychiatry, UMASS Chan Medical School, Worcster, Massachusetts, USA. FIR - Singh, Rachana IR - Singh R IRAD- Department of Pediatrics, Tufts University School of Medicine, Boston, Massachusetts, USA. FIR - Rollins, Caitlin IR - Rollins C IRAD- Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA. FIR - Montgomery, Angela IR - Montgomery A IRAD- Division of Neonatology, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA. FIR - Vaidya, Ruben IR - Vaidya R IRAD- Department of Pediatrics, University of Massachusetts Chan Medical School-Baystate, Springfield, Massachusetts, USA. FIR - Joseph, Robert M IR - Joseph RM IRAD- Department of Anatomy & Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA. FIR - Washburn, Lisa K IR - Washburn LK IRAD- Pediatrics, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. FIR - Gogcu, Semsa IR - Gogcu S IRAD- Section of Neonatology, Department of Pediatrics, Wake Forest School of Medicine, Wake Forest University School of Medicine/Atrium Health Wake Forest, Winston-Salem, North Carolina, USA. FIR - Bear, Kelly IR - Bear K IRAD- Section of Neonatology, Department of Pediatrics, ECU Health, Greenville, North Carolina, USA. FIR - Rollins, Julie V IR - Rollins JV IRAD- Division of Neonatology, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA. FIR - Hooper, Stephen R IR - Hooper SR IRAD- Department of Health Sciences, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FIR - Taylor, Genevieve IR - Taylor G IRAD- Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FIR - Jackson, Wesley IR - Jackson W IRAD- Division of Neonatology, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA. FIR - Thompson, Amanda IR - Thompson A IRAD- Department of Anthropology, Department of Nutrition, University of North Carolina at Chapel Hill, Gillings School of Global Public Health, Chapel Hill, North Carolina, USA. FIR - Daniels, Julie IR - Daniels J IRAD- Epidemiology and Maternal and Child Health, University of North Carolina at Chapel Hill, Gillings School of Global Public Health, Chapel Hill, North Carolina, USA. FIR - Hernandez, Michelle IR - Hernandez M IRAD- Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FIR - Lu, Kun IR - Lu K IRAD- Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FIR - Msall, Michael IR - Msall M IRAD- Kennedy Research Center on Intellectual and Neurodevelopmental Disabilities, University of Chicago Medicine: Comer Children's Hospital, Chicago Illinois, USA. FIR - Lenski, Madeleine IR - Lenski M IRAD- Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, Michigan, USA. FIR - Obeid, Rawad IR - Obeid R IRAD- Pediatrics, Beaumont Hospital, Royal Oak, Michigan, USA. FIR - Pastyrnak, Steven L IR - Pastyrnak SL IRAD- Pediatrics, Corewell Health, Helen DeVos Children's Hospital, Grand Rapids, Michigan, USA. FIR - Jensen, Elizabeth IR - Jensen E IRAD- Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA. FIR - Sakai, Christina IR - Sakai C IRAD- Pediatrics, Mass General Hospital for Children, Boston, Massachusetts, USA. FIR - Santos, Hudson IR - Santos H IRAD- Dean's Office Graduate School, School of Nursing and Health Studies, University of Miami, Coral Gables, Florida, USA. FIR - Kerver, Jean M IR - Kerver JM IRAD- Departments of Epidemiology & Biostatistics, and Pediatrics & Human Development, Michigan State University, College of Human Medicine, East Lansing, Michigan, USA. FIR - Paneth, Nigel IR - Paneth N IRAD- Departments of Epidemiology & Biostatistics, and Pediatrics & Human Development, Michigan State University, College of Human Medicine, East Lansing, Michigan, USA. FIR - Barone, Charles J IR - Barone CJ IRAD- Department of Pediatrics, Henry Ford Health, Detroit, Michigan, USA. FIR - Elliott, Michael R IR - Elliott MR IRAD- Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA. FIR - Ruden, Douglas M IR - Ruden DM IRAD- Department of Obstetrics and Gynecology, Institute of Environmental Health Sciences (IEHS), C.S. Mott Center for Human Health and Development, Wayne State University, Detroit, Michigan, USA. FIR - Fussman, Chris IR - Fussman C IRAD- Lifecourse Epidemiology and Genomics Division, Michigan Department of Health and Human Services (MDHHS), Lansing, Michigan, USA. FIR - Herbstman, Julie B IR - Herbstman JB IRAD- Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USA. FIR - Margolis, Amy IR - Margolis A IRAD- Department of Psychiatry, Columbia University Irving Medical Center, New York, New York, USA. FIR - Schantz, Susan L IR - Schantz SL IRAD- Beckman Institute for Advanced Science and Technology, Department of Comparative Biosciences, University of Illinois Urbana-Champaign, Urbana, Illinois, USA. FIR - Geiger, Sarah Dee IR - Geiger SD IRAD- Beckman Institute for Advanced Science and Technology, Department of Kinesiology and Community Health, University of Illinois Urbana-Champaign, Urbana, Illinois, USA. FIR - Aguiar, Andrea IR - Aguiar A IRAD- Beckman Institute for Advanced Science and Technology, Department of Comparative Biosciences, University of Illinois Urbana-Champaign, Urbana, Illinois, USA. FIR - Tabb, Karen IR - Tabb K IRAD- Beckman Institute for Advanced Science and Technology, Department of Social Work, University of Illinois Urbana-Champaign, Urbana, Illinois, USA. FIR - Strakovsky, Rita IR - Strakovsky R IRAD- Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, USA. FIR - Woodruff, Tracey IR - Woodruff T IRAD- Program on Reproductive Health and the Environment, University of California, San Francisco, San Francisco, California, USA. FIR - Morello-Frosch, Rachel IR - Morello-Frosch R IRAD- Department of Environmental Science, Policy and Management and School of Public Health, University of California, Berkeley, Berkeley, California, USA. FIR - Padula, Amy IR - Padula A IRAD- Program on Reproductive Health and the Environment, University of California, San Francisco, San Francisco, California, USA. FIR - Stanford, Joseph B IR - Stanford JB IRAD- Department of Family and Preventive Medicine, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, Utah, USA. FIR - Porucznik, Christina A IR - Porucznik CA IRAD- Department of Family and Preventive Medicine, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, Utah, USA. FIR - Giardino, Angelo P IR - Giardino AP IRAD- Department of Pediatrics, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, Utah, USA. FIR - Wright, Rosalind J IR - Wright RJ IRAD- Department of Environmental Medicine & Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA. FIR - Wright, Robert O IR - Wright RO IRAD- Department of Environmental Medicine & Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA. FIR - Collett, Brent IR - Collett B IRAD- Department of Psychiatry and Behavioral Medicine, University of Washington, Seattle Children's Research Institute, Seattle, Washington, USA. FIR - Baumann-Blackmore, Nicole IR - Baumann-Blackmore N IRAD- Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA. FIR - Gangnon, Ronald IR - Gangnon R IRAD- Department of Population Health Sciences, University of Wisconsin, Madison, Wisconsin, USA. FIR - Jackson, Daniel J IR - Jackson DJ IRAD- Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA. FIR - McKennan, Chris G IR - McKennan CG IRAD- Department of Statistics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. FIR - Wilson, Jo IR - Wilson J IRAD- Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA. FIR - Altman, Matt IR - Altman M IRAD- Department of Medicine, University of Washington, Seattle, Washington, USA. FIR - Aschner, Judy L IR - Aschner JL IRAD- Department of Pediatrics, Albert Einstein College of Medicine, Hackensack Meridian School of Medicine, Center for Discovery and Innovation, Bronx, New York, USA, Nutley, New Jersey, USA. FIR - Stroustrup, Annemarie IR - Stroustrup A IRAD- Department of Pediatrics, Northwell Health, Cohen Children's Medical Center, and the Zucker School of Medicine at Hofstra / Northwell, New Hyde Park, New York, USA. FIR - Merhar, Stephanie L IR - Merhar SL IRAD- Department of Pediatrics, Cincinnati Children's, Cincinnati, Ohio, USA. FIR - Moore, Paul E IR - Moore PE IRAD- Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FIR - Pryhuber, Gloria S IR - Pryhuber GS IRAD- Department of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA. FIR - Hudak, Mark IR - Hudak M IRAD- Department of Pediatrics, University of Florida College of Medicine, Jacksonville, Florida, USA. FIR - Reynolds Lyndaker, Ann Marie IR - Reynolds Lyndaker AM IRAD- Department of Pediatrics, University of Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA. FIR - Lampland, Andrea L IR - Lampland AL IRAD- Department of Pediatrics, Children's Minnesota, Minneapolis, Minnesota, USA. FIR - Rochelson, Burton IR - Rochelson B IRAD- Department of Obstetrics and Gynecology, Northwell Health and the Zucker School of Medicine at Hofstra / Northwell, New Hyde Park, New York, USA. FIR - Jan, Sophia IR - Jan S IRAD- Department of Pediatrics, Albert Einstein College of Medicine, Hackensack Meridian School of Medicine, Center for Discovery and Innovation, Bronx, New York, USA, Nutley, New Jersey, USA. FIR - Blitz, Matthew J IR - Blitz MJ IRAD- Department of Obstetrics and Gynecology, Northwell Health and the Zucker School of Medicine at Hofstra / Northwell, New Hyde Park, New York, USA. FIR - Katzow, Michelle W IR - Katzow MW IRAD- Department of Pediatrics, Northwell Health, Cohen Children's Medical Center, and the Zucker School of Medicine at Hofstra / Northwell, New Hyde Park, New York, USA. FIR - Brown, Zenobia IR - Brown Z IRAD- Department of Science Education, Northwell Health and the Zucker School of Medicine at Hofstra / Northwell, New Hyde Park, New York, USA. FIR - Chiuzan, Codruta IR - Chiuzan C IRAD- Institute of Health System Science, Northwell Health, Feinstein Institutes for Medical Research, Manhasset, New York, USA. FIR - Rafael, Timothy IR - Rafael T IRAD- Department of Obstetrics and Gynecology, Northwell Health and the Zucker School of Medicine at Hofstra / Northwell, New Hyde Park, New York, USA. FIR - Lewis, Dawnette IR - Lewis D IRAD- Department of Obstetrics and Gynecology, Northwell Health and the Zucker School of Medicine at Hofstra / Northwell, New Hyde Park, New York, USA. FIR - Meirowitz, Natalie IR - Meirowitz N IRAD- Department of Obstetrics and Gynecology, Northwell Health and the Zucker School of Medicine at Hofstra / Northwell, New Hyde Park, New York, USA. FIR - Poindexter, Brenda IR - Poindexter B IRAD- Department of Pediatrics, Children's Healthcare of Atlanta Emory University, Atlanta, Georgia, USA. FIR - Gebretsadik, Tebeb IR - Gebretsadik T IRAD- Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FIR - Osmundson, Sarah IR - Osmundson S IRAD- Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FIR - Straughen, Jennifer K IR - Straughen JK IRAD- Department of Public Health Sciences, Henry Ford Health, Detroit, Michigan, USA. FIR - Eapen, Amy IR - Eapen A IRAD- Division of Allergy and Clinical Immunology, Henry Ford Health, Detroit, Michigan, USA. FIR - Cassidy-Bushrow, Andrea IR - Cassidy-Bushrow A IRAD- Department of Public Health Sciences, Henry Ford Health, Detroit, Michigan, USA. FIR - Wegienka, Ganesa IR - Wegienka G IRAD- Department of Public Health Sciences, Henry Ford Health, Detroit, Michigan, USA. FIR - Sitarik, Alex IR - Sitarik A IRAD- Department of Public Health Sciences, Henry Ford Health, Detroit, Michigan, USA. FIR - Woodcroft, Kim IR - Woodcroft K IRAD- Department of Public Health Sciences, Henry Ford Health, Detroit, Michigan, USA. FIR - Urquhart, Audrey IR - Urquhart A IRAD- Department of Public Health Sciences, Henry Ford Health, Detroit, Michigan, USA. FIR - Levin, Albert IR - Levin A IRAD- Department of Public Health Sciences, Henry Ford Health, Detroit, Michigan, USA. FIR - Johnson-Hooper, Tisa IR - Johnson-Hooper T IRAD- Department of Pediatrics, Henry Ford Health, Detroit, Michigan, USA. FIR - Davidson, Brent IR - Davidson B IRAD- Department of Women's Health, Henry Ford Health, Detroit, Michigan, USA. FIR - Ma, Tengfei IR - Ma T IRAD- Department of Public Health Sciences, Henry Ford Health, Detroit, Michigan, USA. FIR - Barrett, Emily S IR - Barrett ES IRAD- Department of Biostatistics and Epidemiology, Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, New Jersey, USA. FIR - Blaser, Martin J IR - Blaser MJ IRAD- Center for Advanced Biotechnology & Medicine, Rutgers University, Piscataway, New Jersey, USA. FIR - Dominguez-Bello, Maria Gloria IR - Dominguez-Bello MG IRAD- Departments of Biochemistry and Microbiology & Anthropology, Rutgers University, New Brunswick, New Jersey, USA. FIR - Horton, Daniel B IR - Horton DB IRAD- Department of Pediatrics, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey, USA. FIR - Jimenez, Manuel IR - Jimenez M IRAD- Departments of Pediatrics, Family Medicine, and Community Health, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey, USA. FIR - Rosen, Todd IR - Rosen T IRAD- Department of Obstetrics, Gynecology, and Reproductive Sciences, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey, USA. FIR - Palomares, Kristy IR - Palomares K IRAD- Department of Obstetrics and Gynecology, Saint Peter's University Hospital, New Brunswick, New Jersey, USA. FIR - Avalos, Lyndsay A IR - Avalos LA IRAD- Division of Research, Kaiser Permanente Northern California, Oakland, California, USA. FIR - Zhu, Yeyi IR - Zhu Y IRAD- Division of Research, Kaiser Permanente Northern California, Oakland, California, USA. FIR - Hunt, Kelly J IR - Hunt KJ IRAD- Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, USA. FIR - Newman, Roger B IR - Newman RB IRAD- Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, South Carolina, USA. FIR - Bloom, Michael S IR - Bloom MS IRAD- Department of Global and Community Health, George Mason University, Fairfax, Virginia, USA. FIR - Alkis, Mallory H IR - Alkis MH IRAD- Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, South Carolina, USA. FIR - Roberts, James R IR - Roberts JR IRAD- Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina, USA. FIR - Mumford, Sunni L IR - Mumford SL IRAD- Department of Biostatistics, Epidemiology and Informatics, Department of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. FIR - Burris, Heather H IR - Burris HH IRAD- Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. FIR - DeMauro, Sara B IR - DeMauro SB IRAD- Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. FIR - Yee, Lynn M IR - Yee LM IRAD- Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. FIR - Hamvas, Aaron IR - Hamvas A IRAD- Division of Neonatology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. FIR - Olidipo, Antonia F IR - Olidipo AF IRAD- Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Hackensack University Medical Center, Hackensack Meridian School of Medicine, Nutley, New Jersey, USA. FIR - Haddad, Andrew S IR - Haddad AS IRAD- Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Hackensack University Medical Center, Hackensack Meridian School of Medicine, Nutley, New Jersey, USA. FIR - Eiland, Lisa R IR - Eiland LR IRAD- Division of Neonatology, Department of Pediatrics, Hackensack University Medical Center, Hackensack Meridian School of Medicine, Nutley, New Jersey, USA. FIR - Spillane, Nicole T IR - Spillane NT IRAD- Division of Neonatology, Department of Pediatrics, Hackensack University Medical Center, Hackensack Meridian School of Medicine, Nutley, New Jersey, USA. FIR - Suri, Kirin N IR - Suri KN IRAD- Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Hackensack University Medical Center, Hackensack Meridian School of Medicine, Nutley, New Jersey, USA. FIR - Fisher, Stephanie A IR - Fisher SA IRAD- Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. FIR - Goldstein, Jeffrey A IR - Goldstein JA IRAD- Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. FIR - Mithal, Leena B IR - Mithal LB IRAD- Division of Infectious Diseases, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. FIR - DeRegnier, Raye-Ann O IR - DeRegnier RO IRAD- Division of Neonatology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. FIR - Maitre, Nathalie L IR - Maitre NL IRAD- Division of Neonatology, Department of Pediatrics, Emory University School of Medicine and Cerebral Palsy Foundation, Atlanta, Georgia, USA New York, New York, USA. FIR - Nguyen, Ruby Hn IR - Nguyen RH IRAD- Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA. FIR - JaKa, Meghan M IR - JaKa MM IRAD- Division of Research & Evaluation, HealthPartners Institute, Minneapolis, Minnesota, USA. FIR - Sidebottom, Abbey C IR - Sidebottom AC IRAD- Care Delivery Research, Allina Health, Minneapolis, Minnesota, USA. FIR - Paidas, Michael J IR - Paidas MJ IRAD- Department of Obstetrics and Gynecology, University of Miami Miller School of Medicine, Miami, Florida, USA. FIR - Potter, JoNell E IR - Potter JE IRAD- Department of Obstetrics, Gynecology and Reproductive Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA. FIR - Ruby, Natale IR - Ruby N IRAD- Mailman Center for Child Development, University of Miami Miller School of Medicine, Miami, Florida, USA. FIR - Duthely, Lunthita IR - Duthely L IRAD- Department of Obstetrics, Gynecology and Reproductive Sciences and Department of Public Health Sciences, University of Miami School of Medicine, Miami, Florida, USA. FIR - Jayakumar, Arumugam IR - Jayakumar A IRAD- Department of Obstetrics, Gynecology and Reproductive Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA. FIR - Young, Karen IR - Young K IRAD- Department of Pediatrics, University of Miami Miller School of Medicine, Miami, Florida, USA. FIR - Maldonado, Isabel IR - Maldonado I IRAD- School of Nursing and Health Studies, University of Miami, Miami, Florida, USA. FIR - Miller, Meghan IR - Miller M IRAD- Psychiatry and Behavioral Sciences, MIND Institute, University of California Davis, Sacramento, California, USA. FIR - Slaughter, Jonathan L IR - Slaughter JL IRAD- Center for Perinatal Research, Abigail Wexner Research Institute and Division of Neonatology, Nationwide Children's Hospital and Department of Pediatrics, College of Medicine and Division of Epidemiology, College of Public Health, The Ohio State University, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio, USA. FIR - Keim, Sarah A IR - Keim SA IRAD- Center for Biobehavioral Health, Abigail Wexner Research Institute, Nationwide Children's Hospital and Department of Pediatrics, College of Medicine and Division of Epidemiology, College of Public Health, The Ohio State University, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio, USA. FIR - Lynch, Courtney D IR - Lynch CD IRAD- Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, College of Medicine and Division of Epidemiology, College of Public Health, The Ohio State University, Columbus, Ohio, USA. FIR - Venkatesh, Kartik K IR - Venkatesh KK IRAD- Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, College of Medicine and Division of Epidemiology, College of Public Health, The Ohio State University, Columbus, Ohio, USA. FIR - Whitworth, Kristina W IR - Whitworth KW IRAD- Center for Precision Environmental Health and Department of Medicine, Baylor College of Medicine, Houston, Texas, USA. FIR - Symanski, Elaine IR - Symanski E IRAD- Center for Precision Environmental Health and Department of Medicine, Baylor College of Medicine, Houston, Texas, USA. FIR - Northrup, Thomas F IR - Northrup TF IRAD- Department of Family and Community Medicine, University of Texas Health Science Center at Houston (UTHealth Houston) McGovern Medical School, Houston, Texas, USA. FIR - Mendez-Figueroa, Hector IR - Mendez-Figueroa H IRAD- Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Health Science Center at Houston (UTHealth Houston) McGovern Medical School, Houston, Texas, USA. FIR - Mosquera, Ricardo A IR - Mosquera RA IRAD- Department of Pediatrics, University of Texas Health Science Center at Houston (UTHealth Houston) McGovern Medical School, Houston, Texas, USA. FIR - Karagas, Margaret R IR - Karagas MR IRAD- Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA. FIR - Madan, Juliette C IR - Madan JC IRAD- Departments of Psychiatry, Pediatrics & Epidemiology, Geisel School of Medicine at Dartmouth, Dartmouth Hitchcock Medical Center, Hanover, New Hampshire, USA. FIR - MacKenzie, Debra M IR - MacKenzie DM IRAD- Community Environmental Health Program, Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA. FIR - Lewis, Johnnye L IR - Lewis JL IRAD- Community Environmental Health Program, Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA. FIR - Rennie, Brandon J IR - Rennie BJ IRAD- Center for Development and Disability, University of New Mexico, Albuquerque, New Mexico, USA. FIR - Leventhal, Bennett L IR - Leventhal BL IRAD- Community Environmental Health Program, Department of Pharmaceutical Sciences UNM, College of Pharmacy, University of New Mexico Health Sciences Center, University of Chicago, Albuquerque, New Mexico, USA, Chicago, Illinois, USA. FIR - Kim, Young Shin IR - Kim YS IRAD- Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, California, USA. FIR - Bishop, Somer IR - Bishop S IRAD- Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, California, USA. FIR - Nozadi, Sara S IR - Nozadi SS IRAD- Community Environmental Health Program, Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA. FIR - Luo, Li IR - Luo L IRAD- Department of Internal Medicine, Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA. FIR - Lester, Barry M IR - Lester BM IRAD- Department of Pediatrics, Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA. FIR - Marsit, Carmen J IR - Marsit CJ IRAD- Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA. FIR - Everson, Todd IR - Everson T IRAD- Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA. FIR - Loncar, Cynthia M IR - Loncar CM IRAD- Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA. FIR - McGowan, Elisabeth C IR - McGowan EC IRAD- Department of Pediatrics, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA. FIR - Sheinkopf, Stephen J IR - Sheinkopf SJ IRAD- Department of Pediatrics, Thompson Center for Autism & Neurodevelopment, University of Missouri, Columbia, Missouri, USA. FIR - Carter, Brian S IR - Carter BS IRAD- Department of Pediatrics, Children's Mercy-Kansas City, Kansas City, Missouri, USA. FIR - Check, Jennifer IR - Check J IRAD- Department of Pediatrics, Wake Forest School of Medicine, Winston-Salem North Carolina, USA. FIR - Helderman, Jennifer B IR - Helderman JB IRAD- Department of Pediatrics, Wake Forest School of Medicine, Winston-Salem North Carolina, USA. FIR - Neal, Charles R IR - Neal CR IRAD- Department of Pediatrics, University of Hawaii John A Burns School of Medicine, Honolulu, Hawaii, USA. FIR - Smith, Lynne M IR - Smith LM IRAD- Department of Pediatrics, UCLA Clinical and Translational Science Institute at The Lundquist Institute, Harbor-UCLA Medical Center, Los Angeles, California, USA. EDAT- 2025/03/20 00:33 MHDA- 2025/06/16 00:26 PMCR- 2025/03/17 CRDT- 2025/03/19 20:37 PHST- 2024/12/02 00:00 [received] PHST- 2025/02/06 00:00 [revised] PHST- 2025/02/13 00:00 [accepted] PHST- 2025/06/16 00:26 [medline] PHST- 2025/03/20 00:33 [pubmed] PHST- 2025/03/19 20:37 [entrez] PHST- 2025/03/17 00:00 [pmc-release] AID - S0022-3166(25)00165-8 [pii] AID - 10.1016/j.tjnut.2025.02.025 [doi] PST - ppublish SO - J Nutr. 2025 Jun;155(6):1938-1951. doi: 10.1016/j.tjnut.2025.02.025. Epub 2025 Mar 17. PMID- 40106869 OWN - NLM STAT- MEDLINE DCOM- 20250609 LR - 20250609 IS - 1879-0453 (Electronic) IS - 0163-6383 (Linking) VI - 79 DP - 2025 Jun TI - Measurement of the quality of mother-infant feeding interactions across the first year: Reliability and stability of the parent-child early relational assessment. PG - 102038 LID - S0163-6383(25)00012-8 [pii] LID - 10.1016/j.infbeh.2025.102038 [doi] AB - This study examines the psychometric properties of the Parent-Child Early Relational Assessment (PCERA) in the context of mother-infant feeding interaction. Utilizing a longitudinal design, data were collected from 114 mother-infant dyads, including healthy full-term infants and those born prematurely with diagnosed respiratory disease, one group with chronic respiratory disease (Bronchopulmonary Dysplasia) and the second group with acute respiratory disease (Respiratory Distress Syndrome). Observational data were collected at 1, 4, 8, and 12 months post-term age, focusing on parental behavior, infant variables, and dyadic interactions during feeding. Confirmatory factor analysis was employed to assess the congeneric structure of the PCERA across three domains: parental, infant, and dyadic. Results indicated support for the congeneric model in all domains, demonstrating that each factor measured a single common latent variable despite variations in item loadings and error terms. Reliability analysis using Cronbach alpha and McDonald's omega coefficients revealed high internal consistency for all eight PCERA factors, indicative of robust measurement properties (Table 3). Further examination of factorial invariance across four time periods (1, 4, 8, and 12 months) demonstrated consistent measurement properties of the PCERA factors throughout the infant's first year of life. This finding suggests stability and reliability in measuring the underlying constructs of mother-infant feeding interaction over time. The study underscores the utility of the PCERA as an observational tool for assessing various dimensions of parent-child interaction during feeding. Findings support its application in diverse settings, including the study of infants with complex medical conditions, such as prematurity and respiratory disease. Additionally, the study highlights the importance of examining parent and infant characteristics as predictors of feeding interaction quality, aiming to identify dyads at risk of poorer interaction outcomes and inform clinical interventions. CI - Copyright (c) 2025 Elsevier Inc. All rights reserved. FAU - Clark, Roseanne AU - Clark R AD - Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, 6001 Research Park Blvd., Madison, WI 53719, USA. Electronic address: rclark@wisc.edu. FAU - Brown, Roger L AU - Brown RL AD - Schools of Nursing, Medicine, and Public Health, University of Wisconsin-Madison, 3235 Signe Skott Cooper Hall,701 Highland Ave, Madison, WI 53705, USA. Electronic address: roger.brown@wisc.edu. FAU - Pridham, Karen F AU - Pridham KF AD - School of Nursing, University of Wisconsin-Madison, 4220 Signe Skott Cooper Hall, 701 Highland Ave, Madison, WI 53705, USA. Electronic address: kpridham@wisc.edu. LA - eng PT - Journal Article DEP - 20250318 PL - United States TA - Infant Behav Dev JT - Infant behavior & development JID - 7806016 SB - IM MH - Humans MH - *Mother-Child Relations/psychology MH - Female MH - Male MH - Infant MH - Reproducibility of Results MH - Longitudinal Studies MH - Psychometrics MH - Adult MH - Infant, Newborn MH - *Feeding Behavior/psychology MH - Infant, Premature MH - Factor Analysis, Statistical OTO - NOTNLM OT - Longitudinal study OT - Maternal, infant and dyadic behavior and affect OT - Measurement of reliability and stability OT - Mother-infant feeding interaction OT - Observational assessment EDAT- 2025/03/20 00:33 MHDA- 2025/06/10 00:30 CRDT- 2025/03/19 19:00 PHST- 2024/04/26 00:00 [received] PHST- 2025/02/13 00:00 [revised] PHST- 2025/02/14 00:00 [accepted] PHST- 2025/06/10 00:30 [medline] PHST- 2025/03/20 00:33 [pubmed] PHST- 2025/03/19 19:00 [entrez] AID - S0163-6383(25)00012-8 [pii] AID - 10.1016/j.infbeh.2025.102038 [doi] PST - ppublish SO - Infant Behav Dev. 2025 Jun;79:102038. doi: 10.1016/j.infbeh.2025.102038. Epub 2025 Mar 18. PMID- 40106804 OWN - NLM STAT- MEDLINE DCOM- 20250514 LR - 20250516 IS - 1365-2982 (Electronic) IS - 1350-1925 (Print) IS - 1350-1925 (Linking) VI - 37 IP - 6 DP - 2025 Jun TI - Body Surface Gastric Mapping Delineates Specific Patient Phenotypes in Adolescents With Functional Dyspepsia and Gastroparesis. PG - e70018 LID - 10.1111/nmo.70018 [doi] LID - e70018 AB - BACKGROUND: Diagnosing pediatric patients with chronic gastroduodenal symptoms is clinically challenging, with the role of gastric emptying testing being controversial. Body Surface Gastric Mapping (BSGM) is a new diagnostic test that can identify specific patient phenotypes in adults with gastric dysfunction. This study evaluates whether BSGM can delineate specific phenotypes in adolescents and provide clinically meaningful distinctions between gastroparesis and functional dyspepsia diagnoses. METHODS: A prospective cross-sectional study recruited adolescents aged 12 to 21 between 2022 and 2024. Controls were recruited from New Zealand and patients from the Children's Hospital of Philadelphia, USA. BSGM followed a standardized protocol, including simultaneous symptom reporting and completion of validated symptom, psychometric, and physical health questionnaires. KEY RESULTS: Fifty-six subjects were recruited (31 controls, 25 patients); median age 16; 96% of patients were female. Control data showed that adult reference intervals provided an acceptable interpretation framework. Patients with FD (n = 10) and gastroparesis (n = 15) had common symptoms, mental health, quality of life, and functional disability (all p > 0.05). Three distinct BSGM phenotypes were identified: BSGM Normal (n = 10), BSGM Delay (n = 8), and Low Stability/Low Amplitude (n = 7), having spectral differences in BMI-Adjusted Amplitude 34.6 versus 39.1 versus 19.9 (p = 0.01) and Gastric Alimetry Rhythm Index: 0.45 versus 0.45 versus 0.19 (p = 0.003). BSGM phenotypes demonstrated differences in symptoms (nausea p = 0.04), physical health (p = 0.04), and psychometrics (anxiety p = 0.03). CONCLUSION AND INFERENCES: Adolescents with FD and gastroparesis have overlapping clinical profiles, making treatment challenging. Conversely, employing BSGM to categorize patients into distinct phenotypes reveals clinically relevant differences, offering avenues for individualized therapeutic pathways. CI - (c) 2025 The Author(s). Neurogastroenterology & Motility published by John Wiley & Sons Ltd. FAU - Humphrey, Gayl AU - Humphrey G AUID- ORCID: 0000-0002-2837-5707 AD - Department of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand. FAU - Keane, Celia AU - Keane C AD - Department of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand. FAU - Schamberg, Gabriel AU - Schamberg G AUID- ORCID: 0000-0002-4188-9614 AD - Department of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand. AD - Alimetry Ltd., Auckland, New Zealand. FAU - Benitez, Alain AU - Benitez A AD - Division of Gastroenterology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. AD - Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. FAU - Calder, Stefan AU - Calder S AD - Department of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand. AD - Alimetry Ltd., Auckland, New Zealand. FAU - Binghong, Xu AU - Binghong X AD - Division of Gastroenterology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FAU - Sadaka, Christian AU - Sadaka C AUID- ORCID: 0009-0003-5665-5743 AD - Division of Gastroenterology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FAU - Andrews, Christopher N AU - Andrews CN AD - The Division of Gastroenterology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. FAU - O'Grady, Greg AU - O'Grady G AUID- ORCID: 0000-0002-5998-1080 AD - Department of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand. AD - Alimetry Ltd., Auckland, New Zealand. FAU - Gharibans, Armen AU - Gharibans A AUID- ORCID: 0000-0002-9139-4740 AD - Department of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand. AD - Alimetry Ltd., Auckland, New Zealand. AD - Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. FAU - Mousa, Hayat AU - Mousa H AD - Division of Gastroenterology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. AD - Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. LA - eng GR - New Zealand Health Research Council and the Children's Hospital of Philadelphia/ PT - Journal Article DEP - 20250319 PL - England TA - Neurogastroenterol Motil JT - Neurogastroenterology and motility JID - 9432572 SB - IM MH - Humans MH - *Gastroparesis/diagnosis/physiopathology MH - Female MH - Male MH - Adolescent MH - *Dyspepsia/diagnosis/physiopathology MH - Phenotype MH - Cross-Sectional Studies MH - Prospective Studies MH - Child MH - Young Adult MH - Gastric Emptying/physiology MH - *Stomach/physiopathology PMC - PMC12075902 OTO - NOTNLM OT - disorders of gut-brain interaction (DGBI) OT - gastric alimetry OT - gastroduodenal symptoms COIS- G.O.G. and A.G. hold grants and intellectual property in gastrointestinal electrophysiology. G.S., S.C., G.O.G., A.G., and C.N.A. are Alimetry's shareholders and employees. G.O.G. is a Director at The Insides Company. The remaining authors have no conflicts of interest to declare. EDAT- 2025/03/19 18:23 MHDA- 2025/05/14 11:42 PMCR- 2025/05/14 CRDT- 2025/03/19 16:53 PHST- 2025/02/20 00:00 [revised] PHST- 2024/09/09 00:00 [received] PHST- 2025/02/24 00:00 [accepted] PHST- 2025/05/14 11:42 [medline] PHST- 2025/03/19 18:23 [pubmed] PHST- 2025/03/19 16:53 [entrez] PHST- 2025/05/14 00:00 [pmc-release] AID - NMO70018 [pii] AID - 10.1111/nmo.70018 [doi] PST - ppublish SO - Neurogastroenterol Motil. 2025 Jun;37(6):e70018. doi: 10.1111/nmo.70018. Epub 2025 Mar 19. PMID- 40104821 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250320 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - A comparative study of multiple physical assessment indicators to identify psychological symptoms: a cross-sectional study based on Chinese adolescents. PG - 1511639 LID - 10.3389/fnut.2025.1511639 [doi] LID - 1511639 AB - BACKGROUND: Body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) have long been important physical assessment indicators. In recent years a body shape index (ABSI) and body roundness index (BRI) have gained importance as new physical assessment indicators. However, it is unclear how these physical assessment indicators assess psychological symptoms in adolescents. The main purpose of this study was to determine the ability of BMI, WC, WHtR, ABSI, and BRI indicators to recognize psychological symptoms in Chinese adolescents and to examine whether ABSI and BRI are superior to the traditional BMI, WC, and WHtR. METHODS: In this study, 42,472 (boys, 21,026, 49.5%) adolescents aged 12-18 years from six geographic regions in China were assessed for multiple physical assessment indicators (BMI, WC, WHtR, ABSI, BRI) and psychological symptoms from 2015 to 2016. One-way analysis of variance, Spearman's rank test, multifactor logistic regression analysis, and ROC analysis were used to analyze the validity of multiple physical assessment indicators to identify psychological symptoms. RESULTS: The prevalence of psychological symptoms among Chinese adolescents aged 12-18 years was 26.17%. The BMI, WC, WHtR, ABSI, and BRI of the adolescents were (20.19 +/- 3.43) kg/m2, (69.68 +/- 10.05) cm, (0.42 +/- 0.06), (0.06 +/- 0.01), and (2.05 +/- 0.92), respectively. The results of Spearman's rank test showed a positive correlation (p < 0.001) between BMI, WC, WHtR, and BRI were positively associated with psychological symptoms (p < 0.001). The highest Spearman correlation coefficient was found between WC and psychological symptoms (r = 0.134, p < 0.001), and BMI was the lowest (r = 0.108, p < 0.001). Overall, the prevalence of psychological symptoms for all five physical assessment indicators (BMI, WC, WHtR, ABSI, and BRI) showed an increasing trend from Q1 to Q4 (p < 0.001). Overall, WC (AUC: 0.61, 95%CI: 0.61-0.62), WHtR (AUC: 0.61, 95%CI: 0.60-0.61), and BRI (AUC: 0.61, 95%CI: 0.60-0.61) were highly and identically predictive of psychological symptoms; ABSI was the least predictive of psychological symptoms (AUC: 0.51, 95%CI: 0.50 ~ 0.51). CONCLUSION: This study found that neither the ABSI nor the BRI was superior to BMI, WC, or WHtR in predicting psychological symptoms in Chinese adolescents. The ABSI was the least predictive of psychological symptoms in Chinese adolescents, whereas the BRI showed potential as a surrogate for WC and WHtR indicators for assessing psychological symptoms. This study provides additional help and suggestions for better identification of psychological symptoms in Chinese adolescents. CI - Copyright (c) 2025 Bi, Ran, Zhang, Liu, Li, Niu and Yang. FAU - Bi, Cunjian AU - Bi C AD - School of Physical Education, Chizhou University, Chizhou, China. FAU - Ran, Xiaokang AU - Ran X AD - School of Physical Education, Chizhou University, Chizhou, China. FAU - Zhang, Feng AU - Zhang F AD - School of Physical Education, Chizhou University, Chizhou, China. AD - College of Physical Education and Health, East China Normal University, Shanghai, China. FAU - Liu, Yun AU - Liu Y AD - School of Physical Education, Chizhou University, Chizhou, China. FAU - Li, Jun AU - Li J AD - School of Physical Education, Chizhou University, Chizhou, China. FAU - Niu, Yintao AU - Niu Y AD - School of Physical Education, Chizhou University, Chizhou, China. FAU - Yang, Guangyan AU - Yang G AD - School of Physical Education, Chizhou University, Chizhou, China. LA - eng PT - Journal Article DEP - 20250304 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC11913707 OTO - NOTNLM OT - adolescents OT - body roundness index OT - cross-sectional study OT - physical assessment OT - psychological symptoms COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/03/19 06:22 MHDA- 2025/03/19 06:23 PMCR- 2025/01/01 CRDT- 2025/03/19 05:10 PHST- 2024/11/21 00:00 [received] PHST- 2025/02/17 00:00 [accepted] PHST- 2025/03/19 06:23 [medline] PHST- 2025/03/19 06:22 [pubmed] PHST- 2025/03/19 05:10 [entrez] PHST- 2025/01/01 00:00 [pmc-release] AID - 10.3389/fnut.2025.1511639 [doi] PST - epublish SO - Front Nutr. 2025 Mar 4;12:1511639. doi: 10.3389/fnut.2025.1511639. eCollection 2025. PMID- 40104371 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250320 IS - 2277-9531 (Print) IS - 2319-6440 (Electronic) IS - 2277-9531 (Linking) VI - 14 DP - 2025 TI - Association between time consumption of electronic screens with eating behaviors and academic performance for pupils in elementary schools. PG - 36 LID - 10.4103/jehp.jehp_525_24 [doi] LID - 36 AB - BACKGROUND: Evaluate the association between time consumption of electronic screens with eating behaviors and academic performance for pupils at elementary schools in Mosul city. METHOD AND MATERIALS: A descriptive study was carried out at elementary Mosul schools for sixth-grade pupils from December 2023 till March 2024. The sample was selected through two stages, the first stage of elementary schools, which occurred by using the probability (Systematic) sample from 20 elementary schools, the second stage used a nonprobability purposive sample selected sample which entailed 240 pupils from selected elementary schools. A questionnaire was developed that contains four parts: The first part contains two sections: the demographic information of students; the additional portion: information about pupils' time consumption of electronic screens. third part: the pupils' eating behaviors. Part four: the pupils' academic performance. By using a self-administration method for data collection. The questionnaire tool's validity was confirmed via 13 expert panels. A pilot study was conducted to measure reliability from December 28 to 30, 2023. By Cronbach's Alpha measurement, the results were 0. 815 at SPSS version 26. The data analysis techniques employed were statistical methods such as descriptive and statistical inference. RESULTS: The findings of the study are 73.8% (177) of the sample at a level good academic performance with a total mean of 24.35 and a standard deviation of 8.558 that 78.3% (188) of the sample a good level of pupils' behavior around food with a total mean of 49.47 and a standard deviation of 12.460. There is a nonsignificant correlation relationship between all-time consumption of electronic screens with all academic performance and behavior around food results in the study at P value /=60 min of moderate-to-vigorous physical activity per day). RESULTS: Overall, we found an ICC = 0.861 (p < 0.001) between daily step counts measured by the two devices. Bland-Altman analyses revealed a mean difference ("bias") between the devices with the Fitbit recording, on average, 1,388 more steps/day than the accelerometer (Limits of Agreement (LoA) 1,741 to -4,518 steps per day). The ROC revealed a Fitbit cut-point of 12,272 steps/day corresponding to meeting guidelines. CONCLUSIONS: Fitbit ChargeHR devices tend to overestimate daily step counts, but may still provide useful estimates of step counts and patterns in children and youth living with disability. FAU - Voss, Christine AU - Voss C AD - Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. AD - Centre for Chronic Disease Prevention and Management, University of British Columbia, Kelowna, BC, Canada. FAU - Bremer, Emily AU - Bremer E AD - School of Kinesiology, Acadia University, Wolfville, NS, Canada. FAU - Sharma, Ritu AU - Sharma R AD - Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada. FAU - Martin Ginis, Kathleen A AU - Martin Ginis KA AD - Centre for Chronic Disease Prevention and Management, University of British Columbia, Kelowna, BC, Canada. AD - School of Health & Exercise Sciences, University of British Columbia, Kelowna, BC, Canada. AD - Department of Medicine, Faculty of Medicine, University of British Columbia, Kelowna, BC, Canada. FAU - Arbour-Nicitopoulos, Kelly P AU - Arbour-Nicitopoulos KP AD - Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada. LA - eng PT - Journal Article PT - Validation Study DEP - 20250319 PL - England TA - Disabil Rehabil JT - Disability and rehabilitation JID - 9207179 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - Adolescent MH - *Accelerometry/instrumentation MH - Reproducibility of Results MH - *Children with Disabilities/rehabilitation MH - *Exercise MH - *Wearable Electronic Devices MH - *Fitness Trackers MH - *Persons with Disabilities MH - Monitoring, Ambulatory/instrumentation OAB - The accessibility and ease of use of consumer wearable activity monitors make them a potentially useful instrument to help address the paucity of device-based data on the physical activity levels of children and youth living with disabilityThere was generally good agreement for daily step counts between Fitbit devices and research-grade accelerometers, but Fitbits tended to yield considerably higher absolute step counts.The Fitbit ChargeHR provides valid estimates of daily step counts as a measure of physical activity in free-living conditions among ambulatory children and youth living with physical and non-physical disabilities. OABL- eng OTO - NOTNLM OT - Childhood disability OT - activity monitors OT - free-living OT - measurement OT - physical activity OT - wearable technology EDAT- 2025/03/19 06:22 MHDA- 2025/10/15 18:28 CRDT- 2025/03/19 04:02 PHST- 2025/10/15 18:28 [medline] PHST- 2025/03/19 06:22 [pubmed] PHST- 2025/03/19 04:02 [entrez] AID - 10.1080/09638288.2025.2479655 [doi] PST - ppublish SO - Disabil Rehabil. 2025 Oct;47(21):5631-5639. doi: 10.1080/09638288.2025.2479655. Epub 2025 Mar 19. PMID- 40100254 OWN - NLM STAT- MEDLINE DCOM- 20250513 LR - 20261006 IS - 2368-7959 (Electronic) IS - 2368-7959 (Linking) VI - 12 DP - 2025 Mar 18 TI - Problematic Digital Technology Use Measures in Children Aged 0 to 6 Years: Scoping Review. PG - e59869 LID - 10.2196/59869 [doi] LID - e59869 AB - BACKGROUND: In the interest of accurately assessing the effects of digital technology use in early childhood, researchers and experts have emphasized the need to conceptualize and measure children's digital technology use beyond screen time. Researchers have argued that many patterns of early digital technology use could be problematic, resulting in the emerging need to list and examine their measures. OBJECTIVE: We aimed to review existing empirical literature that is using measures for problematic digital technology use in preschool children with the end goal of identifying a set of reliable and valid measures, predicting negative outcomes for children's health, development, or well-being. METHODS: We conducted a scoping review across the Web of Science, PubMed, and Google Scholar databases to identify peer-reviewed publications that were published from January 2012 to December 2023, were written in the English language, described an empirical study, and included a measure of problematic digital technology use beyond exposure (ie, screen time) in children aged 0 to 6 years. RESULTS: The search yielded 95 empirical studies, in which 18 composite measures of problematic use and 23 measures of specific problematic use aspects were found. Existing composite measures conceptualize problematic use as either a group of risky behaviors or as a group of symptoms of a presumed underlying disorder, with the latter being more common. Looking at their conceptual background and psychometric properties, existing composite measures fall short of reliably assessing all the crucial aspects of problematic digital technology use in early childhood. Therefore, the benefits and shortcomings of single-aspect problematic digital technology use measures are evaluated and discussed. CONCLUSIONS: On the basis of current research, early exposure to digital technologies, device use before sleep, and solitary device use represent measures that have been consistently associated with negative outcomes for children. In addition, potential measures of problematic use include device use during meals, device use for emotional regulation, device multitasking, and technoference, warranting further research. Public health benefits of defining problematic digital technology use as a group of risky behaviors rather than a group of addiction symptoms are discussed. CI - (c)Spela Selak, Janja Horvat, Mark Zmavc. Originally published in JMIR Mental Health (https://mental.jmir.org), 18.03.2025. FAU - Selak, Spela AU - Selak S AUID- ORCID: 0000-0002-0346-8296 AD - National Institute of Public Health, Ljubjana, Slovenia. FAU - Horvat, Janja AU - Horvat J AUID- ORCID: 0009-0007-4282-8921 AD - National Institute of Public Health, Ljubjana, Slovenia. FAU - Zmavc, Mark AU - Zmavc M AUID- ORCID: 0000-0002-1100-1493 AD - National Institute of Public Health, Ljubjana, Slovenia. LA - eng PT - Journal Article PT - Scoping Review DEP - 20250318 PL - Canada TA - JMIR Ment Health JT - JMIR mental health JID - 101658926 SB - IM MH - Humans MH - Child, Preschool MH - *Digital Technology/statistics & numerical data MH - Infant MH - Child MH - Screen Time MH - Infant, Newborn PMC - PMC11962332 OTO - NOTNLM OT - children OT - early childhood OT - measures OT - mobile phone OT - problematic digital technology use OT - scoping review COIS- Conflicts of Interest: None declared. EDAT- 2025/03/18 15:23 MHDA- 2025/03/18 18:22 PMCR- 2025/03/18 CRDT- 2025/03/18 11:53 PHST- 2024/04/24 00:00 [received] PHST- 2025/01/07 00:00 [accepted] PHST- 2024/12/20 00:00 [revised] PHST- 2025/03/18 18:22 [medline] PHST- 2025/03/18 15:23 [pubmed] PHST- 2025/03/18 11:53 [entrez] PHST- 2025/03/18 00:00 [pmc-release] AID - v12i1e59869 [pii] AID - 10.2196/59869 [doi] PST - epublish SO - JMIR Ment Health. 2025 Mar 18;12:e59869. doi: 10.2196/59869. PMID- 40099251 OWN - NLM STAT- MEDLINE DCOM- 20250513 LR - 20250513 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 16 DP - 2025 TI - Association between relative fat mass and sterility in women of reproductive age in the United States: results from the 2013-2018 NHANES. PG - 1521247 LID - 10.3389/fendo.2025.1521247 [doi] LID - 1521247 AB - BACKGROUND: A major problem that affects women of reproductive age globally is sterility. A new statistic called Relative Fat Mass (RFM) provides an accurate representation of the percentage of total body fat in people. This study aims to investigate the relationship between RFM and sterility in fertility-age American women. METHODS: This study employed a cross-sectional design using data collected from NHANES between 2013 and 2018. The association between RFM and sterility was investigated using logistic regression analysis, controlling for a number of variables. The results were more resilient when RFM was transformed into a four-category variable in order to further examine the patterns of the association between different RFM levels and sterility. The dose-response association between RFM and sterility was illustrated using restricted cubic spline (RCS) analysis. Sensitivity and subgroup analyses were also conducted to assess the robustness and consistency of the results. RESULTS: This study included 3,197 women aged 18-45, consisting of 2,854 non-sterile participants and 343 sterile participants. First, in the fully adjusted model, RFM and the prevalence of sterility had a positive correlation (OR = 1.05, 95% CI = 1.01-1.09). When converting RFM from a continuous to a categorical variable, the prevalence of sterility was significantly greater in the highest quartile than in the lowest quartile (OR = 2.59, 95% CI = 1.40-4.82). Furthermore, RFM and sterility prevalence were found to be positively linearly correlated by RCS analysis, with sterility rates sharply increasing as RFM levels rose. The positive correlation between RFM and the frequency of sterility was shown to be constant throughout various populations, according to subgroup analysis across stratified parameters. Finally, sensitivity analysis further confirmed the reliability and consistency of the study's findings. CONCLUSION: A representative sample of American women of reproductive age showed a positively correlation between RFM and the prevalence of sterility. RFM may help identify women at risk for sterility, and waist circumference management could potentially help lower the risk of sterility. CI - Copyright (c) 2025 Sun, Lu, Yang and Mao. FAU - Sun, Mengmeng AU - Sun M AD - Department of Obstetrics and Gynecology, Hubei Provincial Clinical Research Center for Cervical Lesions, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China. AD - School of Medicine, Wuhan University of Science and Technology, Wuhan, China. FAU - Lu, Yuxing AU - Lu Y AD - Department of Obstetrics and Gynecology, Hubei Provincial Clinical Research Center for Cervical Lesions, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China. AD - School of Medicine, Wuhan University of Science and Technology, Wuhan, China. FAU - Yang, Xi AU - Yang X AD - Department of Internal Medicine, Affiliated Hospital of Xiangyang Vocational and Technical College, Xiangyang, China. FAU - Mao, Xiaogang AU - Mao X AD - Department of Obstetrics and Gynecology, Hubei Provincial Clinical Research Center for Cervical Lesions, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China. AD - School of Medicine, Wuhan University of Science and Technology, Wuhan, China. LA - eng PT - Journal Article DEP - 20250303 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - Female MH - Adult MH - Cross-Sectional Studies MH - United States/epidemiology MH - Nutrition Surveys MH - Young Adult MH - Middle Aged MH - Adolescent MH - *Infertility, Female/epidemiology MH - *Adipose Tissue MH - Prevalence MH - Body Mass Index PMC - PMC11911180 OTO - NOTNLM OT - NHANES OT - cross-sectional study OT - relative fat mass OT - sterility OT - waist circumference COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/03/18 06:22 MHDA- 2025/03/18 06:23 PMCR- 2025/01/01 CRDT- 2025/03/18 04:44 PHST- 2024/11/16 00:00 [received] PHST- 2025/02/17 00:00 [accepted] PHST- 2025/03/18 06:23 [medline] PHST- 2025/03/18 06:22 [pubmed] PHST- 2025/03/18 04:44 [entrez] PHST- 2025/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2025.1521247 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2025 Mar 3;16:1521247. doi: 10.3389/fendo.2025.1521247. eCollection 2025. PMID- 40097365 OWN - NLM STAT- MEDLINE DCOM- 20250610 LR - 20260821 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 21 IP - 3 DP - 2025 Jul TI - Adaptation of the Remote Food Photography Method to Assess Infant Intake During Bottle-Feeding of Ready-to-Feed Formula. PG - e70016 LID - 10.1111/mcn.70016 [doi] LID - e70016 AB - Bottle-fed infants are at a higher risk for obesity, yet interventions to modify bottle-feeding patterns have shown limited success. Accurate assessment of bottle-feeding patterns is an important basis for targeted interventions. Caregiver reports are susceptible to bias, highlighting the need for more robust methods. One promising approach is the Remote Food Photography Method (RFPM), which involves analysis of digital photographs to objectively assess intake. The purpose of this study was to adapt RFPM to measure the amount of ready-to-feed formula in bottles. Research assistants took digital photographs of bottles with varying amounts of formula and assessed bottle weight to create a predictive model data set (n = 100) and an external validation data set (n = 100). Image processing software was used to determine the area of formula in pixels. Formula area was regressed on actual bottle weight and the resulting regression parameters were used to calculate estimated bottle weights. Predictive models were validated by applying them to the external validation data set. Within the predictive model data set, the mean difference between estimated and actual bottle weight was equivalent within +/-10% equivalence bounds (0.0005 g [90% CI, -0.45, 0.45]). Within the external validation data set, the mean difference between estimated and actual bottle weight was also equivalent within +/-10% equivalence bounds (-17.0 g [90% CI, -18.85, -15.17]). Findings were similar when bottle weight was converted to calories. In sum, the present study provided preliminary evidence for the feasibility and accuracy of an adapted RFPM to assess changes in the amount and caloric content of ready-to-feed formula in bottles. CI - (c) 2025 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Narayanan, Bhagya L AU - Narayanan BL AD - Department of Kinesiology and Public Health, Center for Health Research, California Polytechnic State University, San Luis Obispo, California, USA. FAU - Ventura, Jonathan D AU - Ventura JD AUID- ORCID: 0000-0003-1661-8529 AD - Department of Computer Science & Software Engineering, California Polytechnic State University, San Luis Obispo, California, USA. FAU - Ventura, Alison K AU - Ventura AK AUID- ORCID: 0000-0002-2948-4446 AD - Department of Kinesiology and Public Health, Center for Health Research, California Polytechnic State University, San Luis Obispo, California, USA. LA - eng PT - Journal Article DEP - 20250317 PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - *Photography/methods MH - *Infant Formula MH - Infant MH - *Bottle Feeding MH - Female MH - Male MH - Infant Nutritional Physiological Phenomena PMC - PMC12150128 OTO - NOTNLM OT - bottle-feeding OT - dietary assessment OT - food photography OT - image processing software OT - infant feeding practices OT - rapid infant weight gain OT - ready-to-feed formula COIS- The authors declare no conflicts of interest. EDAT- 2025/03/18 00:26 MHDA- 2025/06/10 13:26 PMCR- 2025/03/17 CRDT- 2025/03/17 23:52 PHST- 2025/01/17 00:00 [revised] PHST- 2024/07/25 00:00 [received] PHST- 2025/02/21 00:00 [accepted] PHST- 2025/06/10 13:26 [medline] PHST- 2025/03/18 00:26 [pubmed] PHST- 2025/03/17 23:52 [entrez] PHST- 2025/03/17 00:00 [pmc-release] AID - MCN70016 [pii] AID - 10.1111/mcn.70016 [doi] PST - ppublish SO - Matern Child Nutr. 2025 Jul;21(3):e70016. doi: 10.1111/mcn.70016. Epub 2025 Mar 17. PMID- 40096148 OWN - NLM STAT- MEDLINE DCOM- 20250513 LR - 20250513 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 25 IP - 5 DP - 2025 Feb 21 TI - The Innovative XClinic Tool: A Pilot Study Validating Its Precision in Measuring Range of Motion in Healthy Individuals. LID - 10.3390/s25051331 [doi] LID - 1331 AB - Kinematics experts and physical therapists have implemented the use of sensors for 3D motion analysis, both for static and dynamic movements. XClinic movement sensors are advanced devices designed to analyze movement patterns with high precision. The aim of this study was to validate wearable XClinic sensors for range of motion (ROM) in healthy subjects and obtain normative data. Participants were enrolled at the Sapienza University of Rome in 2024. All participants had to be healthy subjects aged between 18 and 65 years. Data on their demographics, employment and physical activity were collected. All the subjects were tested to assess the active ROM of their shoulder, hip, knee and ankle bilaterally. The same movements were tested using a goniometer to investigate validity, and SF-36 was administered. Fifty subjects were enrolled. The mean age was 28.2 (SD 10.8) years. For the left shoulder, construct validity showed statistically significant values for flexion, extension and extra-rotation, while for the right shoulder, construct validity showed statistically significant values for all movements except intra-rotation. The results concerning the right hip showed statistically significant values for flexion, extra-rotation, intra-rotation and adduction. The left hip showed statistically significant values for all movements except extension. Both the right and left knees showed statistically significant values for flexion. Both the right and left ankles showed statistically significant values for all movements. XClinic sensors offer a reliable and valid solution for the precise monitoring of the ROM of the shoulder and lower limb joints, making them an invaluable asset for clinicians and researchers. FAU - Galeoto, Giovanni AU - Galeoto G AUID- ORCID: 0000-0002-9043-5686 AD - Department of Human Neurosciences, Sapienza University of Rome, 00185 Rome, Italy. AD - Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy. AD - IRCCS Neuromed, Via Atinense, 18, 86077 Pozzilli, Italy. FAU - Ruotolo, Ilaria AU - Ruotolo I AUID- ORCID: 0000-0003-0817-9714 AD - Department of Human Neurosciences, Sapienza University of Rome, 00185 Rome, Italy. AD - Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy. FAU - Sellitto, Giovanni AU - Sellitto G AUID- ORCID: 0009-0002-8139-7849 AD - Department of Human Neurosciences, Sapienza University of Rome, 00185 Rome, Italy. AD - Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy. FAU - Amadio, Emanuele AU - Amadio E AD - Department of Human Neurosciences, Sapienza University of Rome, 00185 Rome, Italy. FAU - Di Sipio, Enrica AU - Di Sipio E AD - Euleria Health, Via delle Zigherane 4/A, 38068 Trento, Italy. FAU - La Russa, Raffaele AU - La Russa R AUID- ORCID: 0000-0003-3433-7122 AD - Department of Life, Health and Environmental Sciences, University of L'Aquila, 67010 L'Aquila, Italy. FAU - Volonnino, Gianpietro AU - Volonnino G AUID- ORCID: 0000-0002-3178-0797 AD - Department of Anatomical, Histological, Forensic and Orthopaedical Sciences, Sapienza University of Rome, 00185 Rome, Italy. FAU - Frati, Paola AU - Frati P AUID- ORCID: 0000-0002-0358-7965 AD - Department of Anatomical, Histological, Forensic and Orthopaedical Sciences, Sapienza University of Rome, 00185 Rome, Italy. LA - eng PT - Journal Article DEP - 20250221 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - *Range of Motion, Articular/physiology MH - Adult MH - Male MH - Pilot Projects MH - Female MH - Middle Aged MH - Young Adult MH - *Wearable Electronic Devices MH - Biomechanical Phenomena/physiology MH - Adolescent MH - Healthy Volunteers MH - Movement/physiology MH - Aged PMC - PMC11902397 OTO - NOTNLM OT - XClinic OT - inertial sensors OT - psychometric properties OT - range of motion OT - technology COIS- Enrica Di Sipio is affiliated with the company, Euleria Health. The authors declare no conflicts of interest. EDAT- 2025/03/17 18:31 MHDA- 2025/03/17 18:32 PMCR- 2025/02/21 CRDT- 2025/03/17 13:45 PHST- 2024/12/19 00:00 [received] PHST- 2025/02/16 00:00 [revised] PHST- 2025/02/18 00:00 [accepted] PHST- 2025/03/17 18:32 [medline] PHST- 2025/03/17 18:31 [pubmed] PHST- 2025/03/17 13:45 [entrez] PHST- 2025/02/21 00:00 [pmc-release] AID - s25051331 [pii] AID - sensors-25-01331 [pii] AID - 10.3390/s25051331 [doi] PST - epublish SO - Sensors (Basel). 2025 Feb 21;25(5):1331. doi: 10.3390/s25051331. PMID- 40095866 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250319 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 14 IP - 5 DP - 2025 Mar 3 TI - Cross-Cultural Adaptation of a Health-Related Quality-of-Life Questionnaire for Children with Obstructive Sleep Disorders: Spanish Version of the OSD-6. LID - 10.3390/jcm14051709 [doi] LID - 1709 AB - Background/Objectives: To translate the OSD-6 questionnaire (6-item quality of life questionnaire for children with obstructive sleep disorders) into Spanish and to assess its psychometric properties and clinical usefulness. Methods: We included children with obstructive sleep apnea (OSA). All underwent polysomnography before and after adenotonsillectomy. Study variables included age, sex, symptoms, polysomnography values, body measurements, and Mallampati and Brodsky classification. Parents or caregivers completed the OSD-6 at baseline and 3 to 6 months after adenotonsillectomy. Following translation and back-translation of the instrument, we evaluated its internal consistency, reliability, construct validity, concurrent validity, predictive validity, and sensitivity to change. Results: We included 45 boys and 15 girls. Mean body mass index was 18 (standard deviation [SD] 4) kg/m(2) and mean neck circumference was 28 (SD 5) cm. Seven per cent of children had Brodsky grade 0, 12% had grade 1, 27% had grade 2, 45% had grade 3, and 6% had grade 4. Mean apnea-hypopnea index (AHI) was 12 (SD 7) h(-1) before adenotonsillectomy. The overall Cronbach's alpha was 0.8. We found significant concurrent validity in each questionnaire domain and in the overall score. Predictive validity was significant for Mallampati scores (ANOVA p = 0.011) and borderline significant for AHI levels (ANOVA p = 0.069). The study demonstrated excellent sensitivity to change, both in terms of the overall analysis (p < 0.001) and in each domain (p < 0.001). Moreover, the test-retest reliability was found to be equally excellent (global intraclass correlation coefficient = 0.92 [0.89-0.95]). Conclusions: OSD-6 is a valid and reliable instrument to measure quality of life in children with OSA and can be used in Spanish-speaking countries. FAU - Boira, Ignacio AU - Boira I AUID- ORCID: 0000-0001-8225-3623 AD - Pneumology Department, San Juan de Alicante University Hospital, 03550 Alicante, Spain. FAU - Sancho-Chust, Jose Norberto AU - Sancho-Chust JN AUID- ORCID: 0000-0002-3028-0715 AD - Pneumology Department, San Juan de Alicante University Hospital, 03550 Alicante, Spain. FAU - Esteban, Violeta AU - Esteban V AUID- ORCID: 0000-0003-3836-5884 AD - Pneumology Department, San Juan de Alicante University Hospital, 03550 Alicante, Spain. FAU - Pastor, Esther AU - Pastor E AD - Pneumology Department, San Juan de Alicante University Hospital, 03550 Alicante, Spain. FAU - Martinez-Garcia, Miguel Angel AU - Martinez-Garcia MA AUID- ORCID: 0000-0002-7321-1891 AD - Pneumology Department, La Fe University and Polytechnic Hospital, 46026 Valencia, Spain. FAU - Chiner, Eusebi AU - Chiner E AUID- ORCID: 0000-0003-3374-4623 AD - Pneumology Department, San Juan de Alicante University Hospital, 03550 Alicante, Spain. LA - eng GR - 3000euro/Spanish Sleep Network/ PT - Journal Article DEP - 20250303 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC11900155 OTO - NOTNLM OT - OSD-6 OT - adenotonsillar hypertrophy OT - psychometric properties OT - sleep disorders COIS- The authors declare no conflicts of interest. EDAT- 2025/03/17 18:30 MHDA- 2025/03/17 18:31 PMCR- 2025/03/03 CRDT- 2025/03/17 12:55 PHST- 2025/02/04 00:00 [received] PHST- 2025/02/21 00:00 [revised] PHST- 2025/02/26 00:00 [accepted] PHST- 2025/03/17 18:31 [medline] PHST- 2025/03/17 18:30 [pubmed] PHST- 2025/03/17 12:55 [entrez] PHST- 2025/03/03 00:00 [pmc-release] AID - jcm14051709 [pii] AID - jcm-14-01709 [pii] AID - 10.3390/jcm14051709 [doi] PST - epublish SO - J Clin Med. 2025 Mar 3;14(5):1709. doi: 10.3390/jcm14051709. PMID- 40091070 OWN - NLM STAT- MEDLINE DCOM- 20250513 LR - 20260716 IS - 1471-2180 (Electronic) IS - 1471-2180 (Linking) VI - 25 IP - 1 DP - 2025 Mar 17 TI - Full-length 16S rRNA Sequencing Reveals Gut Microbiome Signatures Predictive of MASLD in children with obesity. PG - 146 LID - 10.1186/s12866-025-03849-0 [doi] LID - 146 AB - BACKGROUND: The gut microbiota plays a crucial role in metabolic dysfunction-associated steatotic liver disease (MASLD). Next-generation sequencing technologies are essential for exploring the gut microbiome. While recent advancements in full-length 16S (FL16S) rRNA sequencing offer better taxonomic resolution, whether they establish stronger associations with the risk of MASLD remains to be determined. METHOD: This study utilized long-read FL16S and short-read V3-V4 16S rRNA sequencing to profile gut microbiome compositions in age-, sex-, and BMI-matched case-control pairs of obese children with and without MASLD. A random forest predictive model was employed, using gut-microbiota features selected based on the top 35 most abundant taxa or a linear discriminant analysis score greater than 3. The model's performance was evaluated by comparing the area under the receiver operating characteristic curve (AUC) through a tenfold cross-validation method. RESULTS: Subjects with MASLD exhibited significantly elevated serum alanine aminotransferase, triglycerides, and homeostasis model assessment of insulin resistance levels compared to controls. At the genus level, the gut microbiome compositions detected by both FL16S and V3-V4 sequencing were similar, predominantly comprising Phocaeicola and Bacteroides, followed by Prevotella, Bifidobacterium, Parabacteroides, and Blautia. The AUC for the model based on FL16S sequencing data (86.98%) was significantly higher than that based on V3-V4 sequencing data (70.27%), as determined by DeLong's test (p = 0.008). CONCLUSION: FL16S rRNA sequencing data demonstrates stronger associations with the risk of MASLD in obese children, highlighting its potential for real-world clinical applications. CI - (c) 2025. The Author(s). FAU - Lin, Yu-Cheng AU - Lin YC AD - Department of Pediatrics, Taipei Veterans General Hospital, Taipei City, Taiwan. yclin116@vghtpe.gov.tw. AD - Department of Healthcare Administration, Asia Eastern University of Science and Technology, New Taipei City, Taiwan. yclin116@vghtpe.gov.tw. AD - Department of Pediatrics, Far Eastern Memorial Hospital, New Taipei City, Taiwan. yclin116@vghtpe.gov.tw. FAU - Wu, Chi-Chien AU - Wu CC AD - Department of Pediatrics, Far Eastern Memorial Hospital, New Taipei City, Taiwan. FAU - Li, Yun-Er AU - Li YE AD - Department of Pediatrics, Taipei Veterans General Hospital, Taipei City, Taiwan. FAU - Chen, Chun-Liang AU - Chen CL AD - Department of Pediatrics, Taipei Veterans General Hospital, Taipei City, Taiwan. FAU - Lin, Chia-Ray AU - Lin CR AD - Departments of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan. FAU - Ni, Yen-Hsuan AU - Ni YH AD - Departments of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan. LA - eng SI - SRA/PRJNA1126338 GR - MOST 111-2314-B-418-010/National Science and Technology Council/ PT - Journal Article DEP - 20250317 PL - England TA - BMC Microbiol JT - BMC microbiology JID - 100966981 RN - 0 (RNA, Ribosomal, 16S) RN - 0 (DNA, Bacterial) SB - IM MH - Humans MH - *RNA, Ribosomal, 16S/genetics MH - *Gastrointestinal Microbiome/genetics MH - Male MH - Female MH - Child MH - *Bacteria/classification/genetics/isolation & purification MH - Case-Control Studies MH - *Pediatric Obesity/microbiology/complications MH - *Obesity/microbiology/complications MH - High-Throughput Nucleotide Sequencing MH - *Fatty Liver/microbiology MH - Adolescent MH - Feces/microbiology MH - Sequence Analysis, DNA MH - DNA, Bacterial/genetics PMC - PMC11912586 OTO - NOTNLM OT - 16S rRNA OT - Gut microbiota OT - MASLD OT - Random forest OT - Sequencing COIS- Declarations. Ethics approval and consent to participate: Our study adhered to the Declaration of Helsinki. The study was approved by the ethics committee of Far Eastern Memorial Hospital, and all parents provided their informed consent. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/03/17 15:19 MHDA- 2025/03/17 15:20 PMCR- 2025/03/17 CRDT- 2025/03/17 00:16 PHST- 2024/05/23 00:00 [received] PHST- 2025/02/26 00:00 [accepted] PHST- 2025/03/17 15:20 [medline] PHST- 2025/03/17 15:19 [pubmed] PHST- 2025/03/17 00:16 [entrez] PHST- 2025/03/17 00:00 [pmc-release] AID - 10.1186/s12866-025-03849-0 [pii] AID - 3849 [pii] AID - 10.1186/s12866-025-03849-0 [doi] PST - epublish SO - BMC Microbiol. 2025 Mar 17;25(1):146. doi: 10.1186/s12866-025-03849-0. PMID- 40090764 OWN - NLM STAT- MEDLINE DCOM- 20250513 LR - 20250529 IS - 1365-2214 (Electronic) IS - 0305-1862 (Linking) VI - 51 IP - 2 DP - 2025 Mar TI - Participation of Children With Developmental Coordination Disorder: A Scoping Review. PG - e70059 LID - 10.1111/cch.70059 [doi] AB - BACKGROUND: Children with developmental coordination disorder (DCD) may have participation restrictions; however, there is little information about the specific characteristics of the participation of children with this condition. Given the relevance of participation as an outcome of physiotherapeutic interventions, the objective of this study was to provide a broad review of studies on participation in children with DCD. METHODS: We mapped the literature using a scoping review, through the MEDLINE/PubMed, Scopus, CINAHL and Web of Science databases to identify studies on participation in children with DCD published between 2001 and 2021. The studies were selected by two independent researchers considering the following criteria: (1) studies that evaluated participation and/or constructs related to participation in children with DCD and (2) children aged 5 to 17 years. Data were extracted independently using standardised forms and synthesised after consensus. Study quality was assessed using the Mixed Methods Appraisal Tool (MMAT). RESULTS: A total of 2444 studies were initially found. Fourteen studies met the inclusion criteria, all from high-income countries. The studies included children with a mean age of 9.7 years, and most used appropriate diagnostic criteria and instruments to assess participation with adequate measurement properties. In general, children with DCD have lower levels of participation compared to children with typical development, particularly in physical activities and social participation, with lower engagement in sports teams, leisure and low parental satisfaction. CONCLUSIONS: Although findings of decreased participation in children with DCD were consistent, there are gaps in the literature regarding the understanding of home and school participation. Studies that identify contextual determinants of participation are also needed so participation can be effectively promoted. CI - (c) 2025 John Wiley & Sons Ltd. FAU - de Oliveira Beliche, Thiago Weyk AU - de Oliveira Beliche TW AUID- ORCID: 0000-0002-6098-0149 AD - Graduate Program in Physical Therapy, Universidade Federal de Sao Carlos, Sao Carlos, Brazil. FAU - Weber, Meyene Duque AU - Weber MD AUID- ORCID: 0000-0003-1001-840X AD - Graduate Program in Physical Therapy, Universidade Federal de Sao Carlos, Sao Carlos, Brazil. FAU - Tudella, Eloisa AU - Tudella E AUID- ORCID: 0000-0003-0824-7350 AD - Graduate Program in Physical Therapy, Departament of Physical Therapy, Universidade Federal de Sao Carlos, Sao Carlos, Brazil. FAU - de Campos, Ana Carolina AU - de Campos AC AUID- ORCID: 0000-0001-7267-4467 AD - Graduate Program in Physical Therapy, Departament of Physical Therapy, Universidade Federal de Sao Carlos, Sao Carlos, Brazil. LA - eng GR - Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/ GR - Fundacao de Amparo a Pesquisa do Estado de Sao Paulo/ PT - Journal Article PT - Scoping Review PL - England TA - Child Care Health Dev JT - Child: care, health and development JID - 7602632 SB - IM MH - Humans MH - Child MH - *Motor Skills Disorders/psychology/rehabilitation/physiopathology MH - Adolescent MH - Child, Preschool MH - *Social Participation/psychology OTO - NOTNLM OT - children OT - developmental coordination disorder OT - participation EDAT- 2025/03/17 00:42 MHDA- 2025/03/17 00:43 CRDT- 2025/03/16 22:12 PHST- 2025/02/17 00:00 [revised] PHST- 2024/03/30 00:00 [received] PHST- 2025/02/20 00:00 [accepted] PHST- 2025/03/17 00:43 [medline] PHST- 2025/03/17 00:42 [pubmed] PHST- 2025/03/16 22:12 [entrez] AID - 10.1111/cch.70059 [doi] PST - ppublish SO - Child Care Health Dev. 2025 Mar;51(2):e70059. doi: 10.1111/cch.70059. PMID- 40089113 OWN - NLM STAT- MEDLINE DCOM- 20250410 LR - 20260527 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 209 DP - 2025 May 1 TI - Development and preliminary validation of the comprehensive emotional eating scale (CEES). PG - 107969 LID - S0195-6663(25)00122-9 [pii] LID - 10.1016/j.appet.2025.107969 [doi] AB - In emotional eating (EE), affective states influence desire to eat and/or eating behavior. Most research on EE focuses on over-/under-eating in response to negative emotions, the former of which is related to higher weight and binge-spectrum eating disorder (ED) symptoms while the latter has been implicated in low weight and restrictive-only ED. Individuals endorsing both forms of negative EE are more impaired than those reporting unidirectional negative EE. Less is known about the influence of positive emotions on eating, in part due to a lack of self-report measures of positive over- and under-eating as separate constructs. The current study presents the development, including item reduction and initial factorial validity (primary aims) and convergent validity (secondary aims) of the Comprehensive Emotional Eating Scale (CEES), a four-factor measure of positive and negative over- and under-eating. The initial 134-item pool for the CEES was based on a review of extant emotional eating scales and emotion words from the Positive and Negative Affect Schedule. The item pool was reduced and four factors identified using exploratory graphical analysis. The structure of the final set of 40 items was evaluated using confirmatory factor analysis. Convergent validity of the negative over- and under-eating scales was established using measures of body image-focused eating disorder and ARFID symptoms, and exploratory data on the correlates of positive over- and under eating were reported. The CEES showed preliminary evidence of factorial and convergent validity in a US-based convenience sample. It allows for classification on all four quadrants of emotional eating. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - Hooper, Madison A AU - Hooper MA AD - Vanderbilt University, Department of Psychology, USA. FAU - Dixit, Urvashi AU - Dixit U AD - University of South Alabama, Department of Psychology, USA. FAU - Ahlich, Erica AU - Ahlich E AD - University of South Alabama, Department of Psychology, USA. FAU - Zickgraf, Hana F AU - Zickgraf HF AD - University of South Alabama, Department of Psychology, USA; Rogers Behavioral Health, Research Center, USA. Electronic address: hana.zickgraf@rogersbh.org. LA - eng PT - Journal Article PT - Validation Study DEP - 20250313 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - *Emotions MH - Adult MH - Reproducibility of Results MH - Young Adult MH - Male MH - *Feeding Behavior/psychology MH - Surveys and Questionnaires MH - Factor Analysis, Statistical MH - *Feeding and Eating Disorders/psychology/diagnosis MH - *Eating/psychology MH - Adolescent MH - Psychometrics MH - Middle Aged MH - Body Image/psychology MH - Self Report MH - Emotional Eating OTO - NOTNLM OT - Avoidant/restrictive food intake disorder OT - Binge eating OT - Emotional eating OT - Emotional overeating OT - Emotional undereating OT - Restrictive eating COIS- Declaration of competing interest The authors have no conflicts of interest to report. Funding for the study was provided by startup funds to Dr. Zickgraf from the University of South Alabama EDAT- 2025/03/16 12:45 MHDA- 2025/04/11 00:32 CRDT- 2025/03/15 20:36 PHST- 2024/06/07 00:00 [received] PHST- 2025/02/24 00:00 [revised] PHST- 2025/03/12 00:00 [accepted] PHST- 2025/04/11 00:32 [medline] PHST- 2025/03/16 12:45 [pubmed] PHST- 2025/03/15 20:36 [entrez] AID - S0195-6663(25)00122-9 [pii] AID - 10.1016/j.appet.2025.107969 [doi] PST - ppublish SO - Appetite. 2025 May 1;209:107969. doi: 10.1016/j.appet.2025.107969. Epub 2025 Mar 13. PMID- 40088260 OWN - NLM STAT- MEDLINE DCOM- 20250916 LR - 20260918 IS - 1435-1102 (Electronic) IS - 1434-1816 (Linking) VI - 28 IP - 5 DP - 2025 Oct TI - Effect of prenatal online interventions on postpartum depressive symptoms and well-being: a systematic review and meta-analysis. PG - 1107-1123 LID - 10.1007/s00737-025-01575-0 [doi] AB - BACKGROUND: Depression during pregnancy and postpartum can severely impact psychological and physical well-being, with significant consequences for the child and family. This systematic review and meta-analysis aimed to evaluate the effectiveness of online interventions during pregnancy in reducing postpartum depressive symptoms and enhancing well-being. METHODS: Randomized controlled trials (RCTs) published in English involving pregnant women over 18 years old who participated in online interventions, with or without the support of a health worker, were included. Studies were required to use validated measures for depression and well-being assessed during pregnancy and postpartum. Exclusion criteria comprised literature reviews, meta-analyses, theses, self-help groups and assessment of symptomatology during the period concurrent with maternity blues. A search was conducted using PubMed and EBSCOhost databases, concluding on July 29, 2024. The risk of bias was assessed using RoB 2. RESULTS: Eighteen studies with a total of 9,565 participants met the inclusion criteria. Of these, 38.8% involved clinical populations. Variability was noted in theoretical models, gestational age, professional involvement, and intervention activities. The overall effect size was significant (Cohen's d = 0.37; 95% CI: 0.08 to 0.66; p = 0.0114) with greater efficacy observed in studies using treatment as usual (TAU) as a control and those incorporating relaxation and physical activity. DISCUSSION: Limitations include the absence of standardized protocols and uncertainties regarding long-term efficacy. Although the findings suggest potential effectiveness of online interventions in reducing depressive symptoms, further research is required to address gaps in the existing evidence. OTHER: The study received no funding and was registered in PROSPERO (CRD42023420999). CI - (c) 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature. FAU - Savoia, Alice AU - Savoia A AUID- ORCID: 0009-0009-2286-7848 AD - SFU, Sigmund Freud University - Milan, Ripa Di Porta Ticinese 77, Milan, Italy. AD - IESCUM, Istituto Europeo per lo Studio del Comportamento Umano, Parma, Italy. FAU - Scaini, Simona AU - Scaini S AUID- ORCID: 0000-0002-5978-7165 AD - SFU, Sigmund Freud University - Milan, Ripa Di Porta Ticinese 77, Milan, Italy. FAU - Rossi, Francesca AU - Rossi F AD - IESCUM, Istituto Europeo per lo Studio del Comportamento Umano, Parma, Italy. FAU - Calcinati, Marta AU - Calcinati M AD - IESCUM, Istituto Europeo per lo Studio del Comportamento Umano, Parma, Italy. FAU - Oppo, Annalisa AU - Oppo A AUID- ORCID: 0000-0002-4398-1852 AD - SFU, Sigmund Freud University - Milan, Ripa Di Porta Ticinese 77, Milan, Italy. a.oppo@milano-sfu.it. AD - IESCUM, Istituto Europeo per lo Studio del Comportamento Umano, Parma, Italy. a.oppo@milano-sfu.it. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20250315 PL - Austria TA - Arch Womens Ment Health JT - Archives of women's mental health JID - 9815663 SB - IM MH - Humans MH - Female MH - *Depression, Postpartum/therapy/psychology/prevention & control MH - Pregnancy MH - *Prenatal Care/methods MH - Randomized Controlled Trials as Topic MH - *Internet-Based Intervention MH - *Pregnant People/psychology MH - Depression/therapy MH - Adult OTO - NOTNLM OT - Meta-analysis OT - Online intervention OT - PPD OT - Pregnancy OT - Primary prevention OT - Systematic review COIS- Declarations. Competing interests: The authors of the following manuscript (AS, FR, MC, SS and AO) have no financial or non-financial interests to declare. In addition, they have no competing interests to declare that are relevant to the content of this article. All authors certify that they have no affiliations or involvement with organizations with financial or non-financial interests in the subject matter or materials discussed in this manuscript. The authors have no financial or proprietary interest in any of the material discussed in this article. Finally, authors are responsible for the accuracy of the statements provided in the manuscript. EDAT- 2025/03/16 11:18 MHDA- 2025/09/16 13:03 CRDT- 2025/03/15 12:02 PHST- 2024/02/02 00:00 [received] PHST- 2025/03/04 00:00 [accepted] PHST- 2025/09/16 13:03 [medline] PHST- 2025/03/16 11:18 [pubmed] PHST- 2025/03/15 12:02 [entrez] AID - 10.1007/s00737-025-01575-0 [pii] AID - 10.1007/s00737-025-01575-0 [doi] PST - ppublish SO - Arch Womens Ment Health. 2025 Oct;28(5):1107-1123. doi: 10.1007/s00737-025-01575-0. Epub 2025 Mar 15. PMID- 40087759 OWN - NLM STAT- MEDLINE DCOM- 20250513 LR - 20250513 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 24 IP - 1 DP - 2025 Mar 14 TI - Adherence to diabetes risk reduction diet is associated with metabolic health status in adolescents with overweight or obesity. PG - 41 LID - 10.1186/s12937-025-01111-x [doi] LID - 41 AB - BACKGROUND: Insufficient evidence exists regarding the relationship between diabetes risk reduction diet (DRRD) and metabolic health status in adolescents. The current study aimed to investigate the relationship between DRRD and metabolic health status in Iranian adolescents with overweight/obesity. METHODS: In this cross-sectional study, a multistage cluster random sampling method was used to select 203 overweight/obese adolescents. Dietary intakes were evaluated using a validated 147-item food frequency questionnaire. The following parameters were measured: blood pressure, anthropometric indices, fasting glucose, insulin, and lipid profiles. Participants were classified to metabolically healthy overweight/obese (MHO) or metabolically unhealthy overweight/obese (MUO), based on 2 methods: International Diabetes Federation (IDF) criteria and a combination of IDF and Homeostasis Model Assessment Insulin Resistance (HOMA-IR). RESULTS: Based on IDF criteria, highest vs. lowest adherence to DRRD was associated with a lower odds of having an MUO phenotype in both crude (OR = 0.05; 95%CI: 0.02-0.12) and fully adjusted model (OR = 0.06; 95%CI: 0.02-0.20). Based on IDF/HOMA-IR criteria, similar findings were obtained. This relationship was significant in both genders and was especially significant among adolescents with obesity. In both crude and fully adjusted model, adherence to DRRD was significantly lower the likelihood of having high fasting blood glucose, triglycerides, and HOMA-IR. CONCLUSION: Adolescents who adhered more strictly to DRRD were less likely to be MUO, and have high fasting blood glucose, triglycerides, and HOMA-IR. Additional large-scale prospective studies are necessary to affirm these results. CI - (c) 2025. The Author(s). FAU - Grigorian, Ani AU - Grigorian A AD - Students' Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran. AD - Department of Clinical Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Moradmand, Zahra AU - Moradmand Z AD - Students' Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran. AD - Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, PO Box 81745-151, Isfahan, Iran. FAU - Mirzaei, Saeideh AU - Mirzaei S AD - Department of Community Nutrition, School of Nutrition and Food Science, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Asadi, Ali AU - Asadi A AD - Department of Exercise Physiology, School of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran. FAU - Akhlaghi, Masoumeh AU - Akhlaghi M AD - Department of Community Nutrition, School of Nutrition and Food Science, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Saneei, Parvane AU - Saneei P AD - Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, PO Box 81745-151, Isfahan, Iran. saneeip@yahoo.com. LA - eng PT - Journal Article DEP - 20250314 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 RN - 0 (Blood Glucose) RN - 0 (Insulin) SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - Cross-Sectional Studies MH - Iran MH - *Pediatric Obesity/diet therapy MH - *Overweight/diet therapy MH - Blood Glucose/metabolism MH - Insulin Resistance MH - *Risk Reduction Behavior MH - *Patient Compliance/statistics & numerical data MH - *Health Status MH - Insulin/blood MH - Body Mass Index PMC - PMC11907990 OTO - NOTNLM OT - Adolescents OT - Diabetes risk reduction diet OT - Metabolic health status OT - Obesity OT - Overweight COIS- Declarations. Ethics approval and consent to participate: The study was performed according to the declaration of Helsinki and the STROBE checklist. All study participants signed an informed written consent. The local Ethics Committee of Isfahan University of Medical Sciences approved the study protocol. Competing interests: The authors declare no competing interests. EDAT- 2025/03/16 11:17 MHDA- 2025/03/16 11:18 PMCR- 2025/03/14 CRDT- 2025/03/15 00:45 PHST- 2024/11/25 00:00 [received] PHST- 2025/03/04 00:00 [accepted] PHST- 2025/03/16 11:18 [medline] PHST- 2025/03/16 11:17 [pubmed] PHST- 2025/03/15 00:45 [entrez] PHST- 2025/03/14 00:00 [pmc-release] AID - 10.1186/s12937-025-01111-x [pii] AID - 1111 [pii] AID - 10.1186/s12937-025-01111-x [doi] PST - epublish SO - Nutr J. 2025 Mar 14;24(1):41. doi: 10.1186/s12937-025-01111-x. PMID- 40087638 OWN - NLM STAT- MEDLINE DCOM- 20250513 LR - 20260716 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 25 IP - 1 DP - 2025 Mar 15 TI - Monitoring of child-specific activities in ambulatory children with and without developmental disabilities. PG - 193 LID - 10.1186/s12887-025-05489-9 [doi] LID - 193 AB - BACKGROUND: Pediatric healthcare professionals facilitate children to enhance and maintain a physically active lifestyle. Activity monitors (AM) can help pediatric healthcare professionals assess physical activity in everyday life. However, validation research of activity monitors has often been conducted in laboratories and insight into physical activity of children in their own everyday environment is lacking. Our goal was to study the criterion validity of a prototype AM (AM-p) model in a natural setting. METHODS: Cross-sectional community-based study with ambulatory children (2-19 years) with and without developmental disability. Children wore the AM-p on the ankle and were filmed (gold standard) while performing an activity protocol in a natural setting. We labelled all videos per 5-second epoch with individual activity labels. Raw AM-p data were synchronized with activity labels. Using machine learning techniques, activity labels were subdivided in three pre-defined categories. Accuracy, recall, precision, and F1 score were calculated per category. RESULTS: We analyzed data of 93 children, of which 28 had a developmental disability. Mean age was 11 years (SD 4.5) with 55% girls. The AM-p model differentiated between 'stationary', 'cycling' and 'locomotion' activities with an accuracy of 82%, recall of 78%, precision of 75%, and F1 score of 75%, respectively. Children older than 13 years with typical development can be assessed more accurately than younger children (2-12 years) with and without developmental disabilities. CONCLUSION: The single ankle-worn AM-p model can differentiate between three activity categories in children with and without developmental disabilities with good accuracy (82%). Because the AM-p can be used for a heterogenous group of ambulatory children with and without developmental disabilities, it may support the clinical assessment for pediatric healthcare professionals in the future. CI - (c) 2025. The Author(s). FAU - Engels, Barbara AU - Engels B AD - Research Centre for Healthy and Sustainable Living, Research Group Lifestyle and Health, Utrecht University of Applied Sciences, Utrecht, The Netherlands. AD - UMC Utrecht Brain Center and Center of Excellence for Rehabilitation Medicine, Utrecht, the Netherlands. AD - Research Centre for Healthy and Sustainable Living, Research Group Moving, Growing, and Thriving Together, Utrecht University of Applied Sciences, Utrecht, The Netherlands. FAU - Bloemen, Manon A T AU - Bloemen MAT AD - Research Centre for Healthy and Sustainable Living, Research Group Lifestyle and Health, Utrecht University of Applied Sciences, Utrecht, The Netherlands. manon.bloemen@hu.nl. AD - Research Centre for Healthy and Sustainable Living, Research Group Moving, Growing, and Thriving Together, Utrecht University of Applied Sciences, Utrecht, The Netherlands. manon.bloemen@hu.nl. AD - HU University of Applied Sciences Utrecht, Heidelberglaan 7, Utrecht, 3584 CJ, The Netherlands. manon.bloemen@hu.nl. FAU - Felius, Richard AU - Felius R AD - Research Centre for Healthy and Sustainable Living, Research Group Lifestyle and Health, Utrecht University of Applied Sciences, Utrecht, The Netherlands. AD - Association for Quality in Physical Therapy (SKF), Zwolle, Netherlands. FAU - Damen, Karlijn AU - Damen K AD - Research Centre for Healthy and Sustainable Living, Research Group Lifestyle and Health, Utrecht University of Applied Sciences, Utrecht, The Netherlands. FAU - Bolster, Eline A M AU - Bolster EAM AD - Research Centre for Healthy and Sustainable Living, Research Group Lifestyle and Health, Utrecht University of Applied Sciences, Utrecht, The Netherlands. AD - Research Centre for Healthy and Sustainable Living, Research Group Moving, Growing, and Thriving Together, Utrecht University of Applied Sciences, Utrecht, The Netherlands. FAU - Wittink, Harriet AU - Wittink H AD - Research Centre for Healthy and Sustainable Living, Research Group Lifestyle and Health, Utrecht University of Applied Sciences, Utrecht, The Netherlands. FAU - Engelbert, Raoul H H AU - Engelbert RHH AD - Centre of Expertise Urban Vitality, Faculty of Health, Amsterdam University of Applied Sciences, Amsterdam, The Netherlands. AD - Department of Rehabilitation Medicine, Amsterdam UMC, Location University of Amsterdam, Amsterdam, The Netherlands. AD - Amsterdam Movement Sciences, Rehabilitation and Development, Amsterdam, The Netherlands. FAU - Gorter, Jan Willem AU - Gorter JW AD - UMC Utrecht Brain Center and Center of Excellence for Rehabilitation Medicine, Utrecht, the Netherlands. AD - Department of Rehabilitation, Physical Therapy Science and Sports, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands. AD - Canchild, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. LA - eng GR - MKB12.OO2/Foundation Innovation Alliance-Regional Attention and Action for Knowledge Circulation (SIA Raak)/ PT - Journal Article PT - Validation Study DEP - 20250315 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Child MH - Female MH - Child, Preschool MH - Adolescent MH - Male MH - Cross-Sectional Studies MH - *Developmental Disabilities/physiopathology MH - *Exercise MH - Young Adult MH - Reproducibility of Results MH - *Monitoring, Ambulatory/instrumentation MH - Machine Learning PMC - PMC11909815 OTO - NOTNLM OT - Accuracy OT - Activity monitor OT - Device-measured physical activity OT - Pediatric physiotherapy OT - Performance COIS- Declarations. Ethics approval and consent to participate: The Ethical Screenings Committee for the Health Domain of the University of Applied Sciences Utrecht, the Netherlands, approved the study (reference number 77_000_2018) granted it exempt from the scope of the Medical Research Involving Human Subjects Act (WMO). Prior to testing, children aged 12 years and older, and parents of children aged less than 16 years, gave written informed consent. Consent for publication: We obtained written informed consent of the guardians for the individual images of the child wearing our AM-p. Competing interests: The authors declare no competing interests. EDAT- 2025/03/16 11:15 MHDA- 2025/03/16 11:16 PMCR- 2025/03/15 CRDT- 2025/03/15 00:39 PHST- 2024/07/29 00:00 [received] PHST- 2025/02/05 00:00 [accepted] PHST- 2025/03/16 11:16 [medline] PHST- 2025/03/16 11:15 [pubmed] PHST- 2025/03/15 00:39 [entrez] PHST- 2025/03/15 00:00 [pmc-release] AID - 10.1186/s12887-025-05489-9 [pii] AID - 5489 [pii] AID - 10.1186/s12887-025-05489-9 [doi] PST - epublish SO - BMC Pediatr. 2025 Mar 15;25(1):193. doi: 10.1186/s12887-025-05489-9. PMID- 40086482 OWN - NLM STAT- MEDLINE DCOM- 20250411 LR - 20250421 IS - 1573-2517 (Electronic) IS - 0165-0327 (Linking) VI - 379 DP - 2025 Jun 15 TI - The associations of anxiety, self-efficacy, and family health with obesity-related eating behavior among Chinese adults. PG - 448-456 LID - S0165-0327(25)00378-7 [pii] LID - 10.1016/j.jad.2025.03.039 [doi] AB - BACKGROUND/OBJECTIVE: Relationships among anxiety, self-efficacy, family health, and obesity-related eating behavior (OREB) have not been comprehensively investigated as a holistic system. This study aimed to explore the profiles of anxiety, self-efficacy, and family health in the adult population, and to test their differences in OREB. Furthermore, this study simultaneously examined the moderating effects of self-efficacy and family health on association between anxiety and OREB. METHOD: This study analyzed a nationally representative dataset from the Psychology and Behavior Investigation of Chinese Residents (PBICR) with a sample of 9091 Chinese adults. All participants completed validated questionnaires for study variables. Latent profile analysis (LPA) was used to identify profiles of anxiety, self-efficacy, and family health. ANOVA was performed to examine the differences in OREB among various profiles. Moderation analysis was conducted to test the moderation effects of self-efficacy and family health. RESULTS: Three profiles of anxiety, self-efficacy, and family health were identified, with 25.31 % of participants being classified into the "High anxiety with low levels of self-efficacy and family health" group, which showed the highest level of OREB among the three profiles. Self-efficacy (B = 0.04, 95 % CI = [0.026, 0.062]) and family health (B = 0.06, 95 % CI = [0.040, 0.086]) showed significant moderation effects, with higher self-efficacy and higher family health strengthening the relationship between anxiety and OREB. CONCLUSIONS: Individuals with anxiety are at an elevated risk of developing unhealthy eating behaviors. Additional attention should still be paid to those with high levels of self-efficacy and family health. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Lin, Junxu AU - Lin J AD - School of Psychology, Centre for Studies of Psychological Applications, Guangdong Key Laboratory of Mental Health and Cognitive Science, Ministry of Education Key Laboratory of Brain Cognition and Educational Science, South China Normal University, Guangzhou, China. FAU - Ma, Zijuan AU - Ma Z AD - School of Psychology, Centre for Studies of Psychological Applications, Guangdong Key Laboratory of Mental Health and Cognitive Science, Ministry of Education Key Laboratory of Brain Cognition and Educational Science, South China Normal University, Guangzhou, China. FAU - Chen, Haihui AU - Chen H AD - School of Psychology, Centre for Studies of Psychological Applications, Guangdong Key Laboratory of Mental Health and Cognitive Science, Ministry of Education Key Laboratory of Brain Cognition and Educational Science, South China Normal University, Guangzhou, China. FAU - Fan, Yunge AU - Fan Y AD - School of Psychology, Centre for Studies of Psychological Applications, Guangdong Key Laboratory of Mental Health and Cognitive Science, Ministry of Education Key Laboratory of Brain Cognition and Educational Science, South China Normal University, Guangzhou, China. Electronic address: fanyunge@m.scnu.edu.cn. FAU - Fan, Fang AU - Fan F AD - School of Psychology, Centre for Studies of Psychological Applications, Guangdong Key Laboratory of Mental Health and Cognitive Science, Ministry of Education Key Laboratory of Brain Cognition and Educational Science, South China Normal University, Guangzhou, China. LA - eng PT - Journal Article DEP - 20250312 PL - Netherlands TA - J Affect Disord JT - Journal of affective disorders JID - 7906073 RN - Chinese people SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - *Anxiety/psychology/epidemiology MH - China/epidemiology MH - *Family Health MH - *Feeding Behavior/psychology MH - *Obesity/psychology MH - *Self Efficacy MH - Surveys and Questionnaires MH - East Asian People/psychology OTO - NOTNLM OT - Anxiety OT - Dual moderating effect OT - Family health OT - Latent profile analysis OT - Obesity-related eating behavior OT - Self-efficacy COIS- Declaration of competing interest The authors report no conflict of interest. EDAT- 2025/03/15 00:38 MHDA- 2025/04/11 06:24 CRDT- 2025/03/14 20:13 PHST- 2024/10/12 00:00 [received] PHST- 2025/03/06 00:00 [revised] PHST- 2025/03/10 00:00 [accepted] PHST- 2025/04/11 06:24 [medline] PHST- 2025/03/15 00:38 [pubmed] PHST- 2025/03/14 20:13 [entrez] AID - S0165-0327(25)00378-7 [pii] AID - 10.1016/j.jad.2025.03.039 [doi] PST - ppublish SO - J Affect Disord. 2025 Jun 15;379:448-456. doi: 10.1016/j.jad.2025.03.039. Epub 2025 Mar 12. PMID- 40084212 OWN - NLM STAT- MEDLINE DCOM- 20250513 LR - 20250513 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - From activity to obesity: understanding gender and type of school divide among Saudi adolescents. PG - 1552243 LID - 10.3389/fpubh.2025.1552243 [doi] LID - 1552243 AB - BACKGROUND: Obesity has emerged as a significant predictor of the nationwide burden of non-communicable diseases in Saudi Arabia. OBJECTIVES: This study explores patterns in body mass index (BMI), physical activity (PA), and sedentary behavior (SB) among Saudi adolescents, focusing on variations by gender and school type (public vs. private). It identifies key factors affecting BMI. METHODS: A total of 2,815 students (53.64% male, aged 15.21 +/- 1.55 years) participated. Body weight and composition were determined by bioelectrical impedance, while PA levels and SB scores were assessed through validated questionnaires. Two models were created, one with overall SB and the other with specific SBs. RESULTS: Among participants, 28.4% were overweight/obese, with 17.2% classified as obese. Obesity prevalence was higher in boys (26.9%) compared to girls (6.0%). Overweight prevalence was slightly lower in private schools (9.9%) than in public schools (11.8%), while obesity rates were similar (17.3% vs. 17.2%). A significant association between BMI and school type was identified solely in girls (Model 1: p = 0.004, ES = 0.109; Model 2: p = 0.012, ES = 0.096). Age was positively associated with BMI (Model 1: p < 0.004, ES = 0.025; Model 2: p < 0.001, ES = 0.019), as were SB scores (p < 0.001, ES = 0.17). Conversely, PA levels exhibited a negative correlation with BMI (Model 1: p < 0.001, effect size = -0.104; Model 2: p < 0.001, effect size = -0.106). Polynomial analysis revealed a cubic relationship between BMI and PA across all groups, though with low effect sizes. CONCLUSION: Gender, age, PA, and SB explained a small portion of BMI variance. Future research should investigate mechanisms underlying these non-linear trends and explore additional confounding variables. CI - Copyright (c) 2025 Said and Alibrahim. FAU - Said, Mohamed Ahmed AU - Said MA AD - Department of Physical Education, College of Education, King Faisal University, Al-Ahsa, Saudi Arabia. FAU - Alibrahim, Mohammed Shaab AU - Alibrahim MS AD - Department of Physical Education, College of Education, King Faisal University, Al-Ahsa, Saudi Arabia. LA - eng PT - Journal Article DEP - 20250227 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Male MH - Adolescent MH - Female MH - Body Mass Index MH - *Schools/statistics & numerical data MH - *Exercise MH - *Sedentary Behavior MH - Sex Factors MH - Prevalence MH - *Pediatric Obesity/epidemiology MH - *Obesity/epidemiology MH - Surveys and Questionnaires MH - *Students/statistics & numerical data MH - Overweight/epidemiology PMC - PMC11903440 OTO - NOTNLM OT - adolescents OT - obesity OT - physical activity OT - school type OT - sedentary behavior COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/03/14 11:21 MHDA- 2025/03/14 11:22 PMCR- 2025/02/27 CRDT- 2025/03/14 04:57 PHST- 2024/12/27 00:00 [received] PHST- 2025/02/03 00:00 [accepted] PHST- 2025/03/14 11:22 [medline] PHST- 2025/03/14 11:21 [pubmed] PHST- 2025/03/14 04:57 [entrez] PHST- 2025/02/27 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1552243 [doi] PST - epublish SO - Front Public Health. 2025 Feb 27;13:1552243. doi: 10.3389/fpubh.2025.1552243. eCollection 2025. PMID- 40080326 OWN - NLM STAT- MEDLINE DCOM- 20250512 LR - 20250512 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 30 IP - 1 DP - 2025 Mar 13 TI - Night eating and night eating syndrome: associations with dysfunctional eating behaviors, mental health and quality-of-life measures in Australian adults. PG - 24 LID - 10.1007/s40519-025-01732-5 [doi] LID - 24 AB - PURPOSE: The association of night eating (NE) and NE syndrome (NES) with dysfunctional eating behaviors, mental health and quality-of-life outcomes has been little explored in the general population. The objective of this study was to explore this for dysfunctional eating behaviors: binge-eating, use of purging, dietary restriction, use of medication to control weight; mental health: anxiety/depression; and quality-of-life outcomes: mental and physical health-related quality of life (M/PHRQoL). NE captured whether in the past 3 months, the respondents had any episodes of waking from sleep and eating, or episodes of eating a very large amount of food after evening meal excluding any such events at social gatherings or travelling overseas on a night flight or because of work shifts. NES was defined by at least weekly episodes of NE with 'a lot' of distress. METHODS: In 2017, 2977 adults from randomly selected households in South Australia were interviewed. Analyses for bivariate association were conducted using weighted tetrachoric and weighted polychoric correlations, and ordinal and binary logistic models, to determine the association between current (3 months) NE or NES as an outcome, and binge-eating, use of purging, dietary restriction, use of medication to control weight, anxiety/depression, mental and physical health-related quality of life (M/PHRQoL) as predictors after controlling for age, sex, and body weight. All analyses adjusted for design effect by stratified cluster sampling. RESULTS: Ordinal logistic regression found significantly higher odds of episodes of NE with binge-eating (OR = 1.756, 95% CI 1.527-2.020, p < 0.001), and significantly lower odds with increased MHRQoL (OR = 0.948, 95% 0.921-0.975, p < 0.001) and increased PHRQoL (OR = 0.976, 95% CI 0.966-0.986, p < 0.001). Binary logistic regression found significantly higher odds of NES with binge-eating (OR = 2.62, p < 0.001), and restrictive dieting (OR = 2.491, 95% CI 1.647-3.769, p < 0.01), and significantly lower odds with MHRQoL (OR = 0.913, 95% CI 0.879-0.948, p < 0.001). CONCLUSIONS: Those with a history of binge-eating have higher likelihood of having both NE and NES which are also increased for the former in those with poorer MHRQoL and PHRQoL, and for the latter in only those with poorer MHRQoL. Revisions of diagnostic schemes may consider these findings in the context of delineation of boundaries between eating disorder syndromes. LEVELS OF EVIDENCE: Multivariate binary logistic regression analyses found there were significantly higher odds of having night eating syndrome in association with binge eating and restrictive dieting and significantly lower odds of night eating syndrome in association with increases in MHRQoL. These results support the Muscatello et al. (Aust N Z J Psychiatry 56:120-1362022, 2022) review noting associations and overlap between night eating syndrome and other eating disorders characterized by recurrent binge-eating, and the reported associations with disorders of restrictive eating. As both night eating and binge-eating are symptoms of over or excessive eating this was not unexpected. However, the findings at a diagnostic level in this study did also support research that has found overlap between night eating syndrome and disorders characterized by restrictive eating and/or purging behaviors. By "at a diagnostic level" what we meant was when at a level associated with marked distress, as the DSM requires either functional impairment or psychological distress to be present as a defining feature of any mental health disorder and distress is a defining feature of NES (American Psychiatric Association 2013). Diagnostic and Statistical Manual of Mental Disorders: DSM-5. Arlington, American Psychiatric Publishing Inc.). MHRQoL rather than PHRQoL was associated with night eating syndrome. More research is required to confirm this result and it does not negate the clinical importance of consideration of physical health status of people with night eating syndrome (Muscatello et al. Aust N Z J Psychiatry 56:120-136, 2022; Sakthivel et al. Eat Weight Disorders-Stud Anorexia Bulimia Obes 28:77, 2023). This study did not find that those who have perceived subjective anxiety/depression have significantly higher odds of NE as well as NES. This may have been because the present study did not have an assessment of depression or anxiety using a validated instrument, but rather a broad self-reported experience of current perceived anxiety and/or depression. Other studies have been also more often conduced in clinical populations which may be expected to have higher rates of mental health comorbidities (Muscatello et al. Aust N Z J Psychiatry 56:120-136, 2022) than this general population sample. PUBLIC SIGNIFICANCE STATEMENT: To our knowledge this is the first study in a representative adult general population examining the relationships between night eating (NE), NE syndrome (NES) and binge eating, purging, strict dieting and general anxiety or general depression. Those with a history of binge eating and having poorer MHRQoL and PHRQoL have higher likelihoods of experiencing NE. The same associations of these factors except for that of PHRQoL were found with NES. Revisions of diagnostic schemes may consider these findings in the context of delineation of boundaries between eating disorder syndromes. As the nature of overeating is defined more broadly in NES than in other eating disorders it is important to explore all forms of overeating when undertaking estimates of the population prevalence and burden of eating disorder. CI - (c) 2025. The Author(s). FAU - Mannan, Haider AU - Mannan H AD - THRI, Western Sydney University, Campbelltown, NSW, Australia. h.mannan@westernsydney.edu.au. FAU - Touyz, Stephen AU - Touyz S AD - Inside Out Institute, University of Sydney, Camperdown, NSW, Australia. FAU - Hay, Phillipa AU - Hay P AD - THRI, Western Sydney University, Campbelltown, NSW, Australia. AD - Mental Health Services, South Western Sydney Local Health District, Campbelltown, NSW, Australia. LA - eng PT - Journal Article DEP - 20250313 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - *Quality of Life/psychology MH - Female MH - Male MH - Adult MH - Middle Aged MH - *Feeding Behavior/psychology MH - *Mental Health MH - *Night Eating Syndrome/psychology MH - Anxiety/psychology MH - Young Adult MH - Depression/psychology MH - Australia MH - Adolescent MH - *Feeding and Eating Disorders/psychology PMC - PMC11906568 OTO - NOTNLM OT - Binge-eating OT - Mental health OT - Night eating OT - Night eating syndrome OT - Purging OT - Quality of life COIS- Declarations. Ethics approval consent to participate: The study was approved by the University of Adelaide Human Research Ethics Committee Protocol Number H-097-2010 and participants provided informed consent. We received Ethics exemption to conduct later analyses on de-identifed data from Western Sydney University HREC. Informed consent was obtained from all individual participants included in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/03/14 11:25 MHDA- 2025/03/14 11:26 PMCR- 2025/03/13 CRDT- 2025/03/13 12:39 PHST- 2024/12/20 00:00 [received] PHST- 2025/02/20 00:00 [accepted] PHST- 2025/03/14 11:26 [medline] PHST- 2025/03/14 11:25 [pubmed] PHST- 2025/03/13 12:39 [entrez] PHST- 2025/03/13 00:00 [pmc-release] AID - 10.1007/s40519-025-01732-5 [pii] AID - 1732 [pii] AID - 10.1007/s40519-025-01732-5 [doi] PST - epublish SO - Eat Weight Disord. 2025 Mar 13;30(1):24. doi: 10.1007/s40519-025-01732-5. PMID- 40077724 OWN - NLM STAT- MEDLINE DCOM- 20250313 LR - 20250512 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 5 DP - 2025 Feb 28 TI - Validation Evidence for the Children's Eating Behaviour Questionnaire (CEBQ) in Brazil: A Cross-Sectional Study. LID - 10.3390/nu17050851 [doi] LID - 851 AB - BACKGROUND: Eating behavior is influenced by intrinsic and extrinsic factors from early infancy, shaping an individual's relationship with food. Tools such as the Children's Eating Behaviour Questionnaire (CEBQ) were designed to evaluate these patterns in children and facilitate the early identification of potential issues. OBJECTIVE: The objective of this study is to validate the CEBQ for use in Brazilian children and adolescents. METHODS: Parents/caregivers of students from public and private schools in southern Brazil completed the CEBQ. Anthropometric measurements of students' weight and height were also taken. Psychometric properties were assessed by internal consistency (Cronbach's alpha), construct validity (exploratory factor analysis), and criterion validity (correlation between CEBQ scores and participants' body mass index-for-age categories). RESULTS: A total of 205 participants aged 3 to 13 and their caregivers participated in this study. Exploratory factor analysis resulted in a five-factor questionnaire and a reduction of four items. All remaining items had a factor loading > 0.3. Cronbach's alpha values were satisfactory, with values >/= 0.7 in all factors, supporting the instrument's internal consistency. The findings also showed significant associations between CEBQ scales and participants' BMI for age. CONCLUSIONS: The findings of this study provide evidence that the CEBQ is a valid tool for assessing eating behavior in Brazilian children and adolescents. FAU - Peuckert, Marina Zanette AU - Peuckert MZ AUID- ORCID: 0000-0002-7159-9482 AD - Graduate Program Pediatrics and Child Health, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Ipiranga Avenue, 6681, Porto Alegre 90610-970, RS, Brazil. FAU - Ayala, Camila Ospina AU - Ayala CO AD - Graduate Program Pediatrics and Child Health, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Ipiranga Avenue, 6681, Porto Alegre 90610-970, RS, Brazil. FAU - Mattiello, Rita AU - Mattiello R AUID- ORCID: 0000-0002-0548-3342 AD - School Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos, 2400, Porto Alegre 90010-150, RS, Brazil. FAU - Viola, Thiago Wendt AU - Viola TW AUID- ORCID: 0000-0001-5446-1695 AD - Graduate Program Pediatrics and Child Health, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Ipiranga Avenue, 6681, Porto Alegre 90610-970, RS, Brazil. FAU - Walker, Marthina Streda AU - Walker MS AD - Graduate Program Pediatrics and Child Health, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Ipiranga Avenue, 6681, Porto Alegre 90610-970, RS, Brazil. FAU - Feoli, Ana Maria Pandolfo AU - Feoli AMP AD - Graduate Program Pediatrics and Child Health, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Ipiranga Avenue, 6681, Porto Alegre 90610-970, RS, Brazil. FAU - Drumond Costa, Caroline Abud AU - Drumond Costa CA AD - Graduate Program Pediatrics and Child Health, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Ipiranga Avenue, 6681, Porto Alegre 90610-970, RS, Brazil. LA - eng PT - Journal Article PT - Validation Study DEP - 20250228 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Brazil MH - Child MH - Female MH - Adolescent MH - Male MH - *Feeding Behavior MH - Cross-Sectional Studies MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Psychometrics MH - Child, Preschool MH - *Child Behavior MH - Body Mass Index MH - Factor Analysis, Statistical PMC - PMC11902245 OTO - NOTNLM OT - children's eating behavior OT - children's eating behaviour questionnaire OT - exploratory factor analysis OT - psychometrics OT - validation study COIS- The authors declare no conflicts of interest. EDAT- 2025/03/13 06:28 MHDA- 2025/03/13 06:29 PMCR- 2025/02/28 CRDT- 2025/03/13 01:12 PHST- 2024/11/05 00:00 [received] PHST- 2025/01/12 00:00 [revised] PHST- 2025/01/22 00:00 [accepted] PHST- 2025/03/13 06:29 [medline] PHST- 2025/03/13 06:28 [pubmed] PHST- 2025/03/13 01:12 [entrez] PHST- 2025/02/28 00:00 [pmc-release] AID - nu17050851 [pii] AID - nutrients-17-00851 [pii] AID - 10.3390/nu17050851 [doi] PST - epublish SO - Nutrients. 2025 Feb 28;17(5):851. doi: 10.3390/nu17050851. PMID- 40077665 OWN - NLM STAT- MEDLINE DCOM- 20250512 LR - 20250512 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 5 DP - 2025 Feb 25 TI - Psychometric Evaluation of Eating Behaviors and Mental Health Among University Students in China and Pakistan: A Cross-Cultural Study. LID - 10.3390/nu17050795 [doi] LID - 795 AB - BACKGROUND/OBJECTIVES: Eating disorders, including food neophobia and restrictive eating behaviors, are pervasive among university students. This study evaluated the psychometric properties of the Nine-Item Avoidant/Restrictive Food Intake Disorder Scale (NIAS), Dusseldorf Orthorexia Scale (DOS), Night Eating Syndrome Questionnaire (NESQ), Zung's Self-Rating Depression Scale (SDS), and Perceived Stress Scale (PSS) among university students in China and Pakistan to assess reliability and validity and explore the relationships between eating behaviors and mental health. METHODS: Initially, responses from 1056 university students from China and Pakistan were obtained, which were reduced to 1002 after screening. Sociodemographic data were collected. Descriptive statistics, reliability analysis, and Confirmatory Factor Analysis (CFA) were performed using SPSS and Analysis of Moment Structures (AMOS). RESULTS: The demographic data showed that 52% of the participants were female and 48% were male, with a mean age of 22.13 +/- 3.86 years. Most were single (93.2%) and had a mean BMI of 22.06 +/- 4.02 kg/m(2). The NIAS showed high internal consistency (Cronbach's Alpha: 0.731), and the CFA revealed strong factor loadings (0.57-0.79). The DOS showed good psychometric properties (factor loadings: 0.53-0.77). The NESQ indicated higher night eating behaviors in Chinese students, who also had higher stress (PSS: Mean Difference = 4.116, 95% CI: 3.36-4.87) and depression (SDS: Mean Difference = 0.229, 95% CI: 0.19-0.27) compared to Pakistani students, who showed more restrictive eating behaviors (NIAS: Mean Difference = -0.422, 95% CI: -0.51 to -0.33). CONCLUSIONS: The psychometric evaluation demonstrated strong reliability and validity in assessing eating behaviors and mental health among university students in China and Pakistan. These findings highlight cultural differences, with Chinese students showing higher levels of stress and depression and Pakistani students exhibiting more restrictive eating behaviors. These results suggest the need for culturally tailored interventions to address food-related mental health issues and improve students' well-being. FAU - Shah, Muhammad Waseem AU - Shah MW AUID- ORCID: 0000-0001-5222-4629 AD - Key Laboratory of Environmental Medicine Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China. FAU - Yan, Qinyu AU - Yan Q AUID- ORCID: 0000-0001-9938-4777 AD - Key Laboratory of Environmental Medicine Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China. FAU - Pan, Da AU - Pan D AD - Key Laboratory of Environmental Medicine Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China. FAU - Sun, Guiju AU - Sun G AUID- ORCID: 0000-0001-5969-2185 AD - Key Laboratory of Environmental Medicine Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China. LA - eng PT - Journal Article DEP - 20250225 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Male MH - Pakistan MH - *Psychometrics MH - *Students/psychology/statistics & numerical data MH - China/epidemiology MH - Young Adult MH - *Feeding Behavior/psychology MH - Universities MH - Reproducibility of Results MH - Adult MH - Cross-Cultural Comparison MH - *Mental Health MH - Surveys and Questionnaires MH - *Feeding and Eating Disorders/psychology MH - Adolescent MH - Stress, Psychological MH - Factor Analysis, Statistical PMC - PMC11901892 OTO - NOTNLM OT - depressive symptoms OT - dietary habits OT - eating disorders OT - food neophobia OT - mental health assessment OT - night eating syndrome OT - orthorexia nervosa OT - perceived stress OT - psychological well-being OT - psychometric evaluation COIS- The authors declare no conflicts of interest. EDAT- 2025/03/13 06:27 MHDA- 2025/03/13 06:28 PMCR- 2025/02/25 CRDT- 2025/03/13 01:12 PHST- 2025/02/08 00:00 [received] PHST- 2025/02/22 00:00 [revised] PHST- 2025/02/23 00:00 [accepted] PHST- 2025/03/13 06:28 [medline] PHST- 2025/03/13 06:27 [pubmed] PHST- 2025/03/13 01:12 [entrez] PHST- 2025/02/25 00:00 [pmc-release] AID - nu17050795 [pii] AID - nutrients-17-00795 [pii] AID - 10.3390/nu17050795 [doi] PST - epublish SO - Nutrients. 2025 Feb 25;17(5):795. doi: 10.3390/nu17050795. PMID- 40076962 OWN - NLM STAT- MEDLINE DCOM- 20250513 LR - 20250513 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 26 IP - 5 DP - 2025 Mar 6 TI - GDF15, EGF, and Neopterin in Assessing Progression of Pediatric Chronic Kidney Disease Using Artificial Intelligence Tools-A Pilot Study. LID - 10.3390/ijms26052344 [doi] LID - 2344 AB - Cell-mediated immunity and chronic inflammation are hallmarks of chronic kidney disease (CKD). Growth differentiation factor 15 (GDF15) is a marker of inflammation and an integrative signal in stress conditions. Epidermal growth factor (EGF) is a tubule-specific protein that modulates the regeneration of injured renal tubules. Neopterin is a product of activated monocytes and macrophages and serves as a marker of cell-mediated immunity. Our aim was to assess the role of the above-mentioned parameters in the progression of CKD in children using artificial intelligence tools. The study group consisted of 151 children with CKD stages 1-5. EGF, GDF15, and neopterin serum concentrations were assessed by ELISA. The patients' anthropometric data, biochemical parameters, EGF, GDF15, and neopterin serum values were implemented into the artificial neural network (ANN). The most precise model contained EGF, GDF15, and neopterin as input parameters and classified patients into either CKD 1-3 or CKD 4-5 groups with an excellent accuracy of 96.77%. The presented AI model, with serum concentrations of EGF, GDF15, and neopterin as input parameters, may serve as a useful predictor of CKD progression. It suggests the essential role of inflammatory processes in the renal function decline in the course of CKD in children. FAU - Musial, Kinga AU - Musial K AUID- ORCID: 0000-0002-9000-7585 AD - Department of Pediatric Nephrology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland. FAU - Stojanowski, Jakub AU - Stojanowski J AUID- ORCID: 0000-0002-0527-2190 AD - Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland. FAU - Bargenda-Lange, Agnieszka AU - Bargenda-Lange A AD - Department of Pediatric Nephrology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland. FAU - Golebiowski, Tomasz AU - Golebiowski T AUID- ORCID: 0000-0001-5477-2020 AD - Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland. LA - eng GR - SUB.C210.19.045/Wroclaw Medical University/ PT - Journal Article DEP - 20250306 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - 670-65-5 (Neopterin) RN - 0 (Growth Differentiation Factor 15) RN - 62229-50-9 (Epidermal Growth Factor) RN - 0 (GDF15 protein, human) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Neopterin/blood MH - Child MH - *Growth Differentiation Factor 15/blood MH - *Renal Insufficiency, Chronic/blood/diagnosis/pathology MH - Male MH - Female MH - Pilot Projects MH - *Epidermal Growth Factor/blood MH - Disease Progression MH - Biomarkers/blood MH - Adolescent MH - *Artificial Intelligence MH - Child, Preschool MH - Neural Networks, Computer PMC - PMC11899747 OTO - NOTNLM OT - artificial intelligence OT - chronic inflammation OT - epidermal growth factor OT - growth differentiation factor 15 OT - leave-one-out cross-validation (LOOCV) method OT - multilayer perceptron (MLP) network model COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2025/03/13 06:28 MHDA- 2025/03/13 06:29 PMCR- 2025/03/06 CRDT- 2025/03/13 01:08 PHST- 2025/02/02 00:00 [received] PHST- 2025/03/01 00:00 [revised] PHST- 2025/03/04 00:00 [accepted] PHST- 2025/03/13 06:29 [medline] PHST- 2025/03/13 06:28 [pubmed] PHST- 2025/03/13 01:08 [entrez] PHST- 2025/03/06 00:00 [pmc-release] AID - ijms26052344 [pii] AID - ijms-26-02344 [pii] AID - 10.3390/ijms26052344 [doi] PST - epublish SO - Int J Mol Sci. 2025 Mar 6;26(5):2344. doi: 10.3390/ijms26052344. PMID- 40074527 OWN - NLM STAT- MEDLINE DCOM- 20250825 LR - 20260708 IS - 1469-7610 (Electronic) IS - 0021-9630 (Print) IS - 0021-9630 (Linking) VI - 66 IP - 9 DP - 2025 Sep TI - Neurodevelopmental and psychiatric conditions in 600 Swedish children with the avoidant/restrictive food intake disorder phenotype. PG - 1333-1344 LID - 10.1111/jcpp.14134 [doi] AB - BACKGROUND: Avoidant restrictive food intake disorder (ARFID) is a feeding and eating disorder characterized by extremely restricted dietary variety and/or quantity resulting in serious consequences for physical health and psychosocial functioning. ARFID often co-occurs with neurodevelopmental conditions (NDCs) and psychiatric conditions, but previous data are mostly limited to small clinical samples examining a narrow range of conditions. Here, we examined NDCs and psychiatric conditions in a large, population-based group of children with ARFID. METHODS: In 30,795 children born 1992-2008 in Sweden, ARFID was assessed using parent reports and clinical diagnoses from national health registers. Parents further reported symptoms of NDCs and psychiatric conditions at child age 9 or 12 years. Validated cutoffs were applied to the resulting symptoms scores to identify above-threshold conditions. We then examined whether ARFID was associated with higher symptom scores (19 outcomes) and higher likelihood of above-threshold conditions (15 outcomes) using linear and logistic regressions. RESULTS: Most prevalent in children with ARFID were separation anxiety (29.0%), oppositional defiant disorder (19.4%), attention deficit hyperactivity disorder (ADHD, 16.9%), panic disorder (15.3%), and tic disorders (14.8%). For all measured co-occurring conditions, ARFID was associated with significantly higher symptom scores (standardized beta range: 0.6-1.5) and higher odds of above-threshold conditions (odds ratio [OR] range: 3.3-13.7). The conditions with the highest increase in odds were autism (OR = 13.7) and ADHD (OR = 9.4). We did not find any sex-specific differences in co-occurring conditions. CONCLUSIONS: This study highlights the co-occurrence of a broad range of NDCs and psychiatric conditions with ARFID in a large, non-clinical cohort. Our findings underscore that children with ARFID face significant burden from multiple co-existing conditions which should be considered during assessment and treatment. CI - (c) 2025 The Author(s). Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health. FAU - Nyholmer, Manda AU - Nyholmer M AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Wronski, Marie-Louis AU - Wronski ML AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. AD - Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. AD - Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, Germany. FAU - Hog, Liv AU - Hog L AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Kuja-Halkola, Ralf AU - Kuja-Halkola R AUID- ORCID: 0000-0002-3765-2067 AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Lichtenstein, Paul AU - Lichtenstein P AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Lundstrom, Sebastian AU - Lundstrom S AD - Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Larsson, Henrik AU - Larsson H AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. AD - School of Medical Sciences, Orebro University, Orebro, Sweden. FAU - Taylor, Mark J AU - Taylor MJ AUID- ORCID: 0000-0001-5161-4182 AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Bulik, Cynthia M AU - Bulik CM AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. AD - Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. FAU - Dinkler, Lisa AU - Dinkler L AUID- ORCID: 0000-0002-9901-4984 AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. LA - eng GR - R01 MH119084/MH/NIMH NIH HHS/United States GR - Swedish Mental Health Foundation/ GR - 538-2013-8864/Vetenskapsradet/ GR - R276-2018-4581/Lundbeck Foundation/ GR - Stipendium till Jon Aurells minne/ GR - R01MH118278/MH/NIMH NIH HHS/United States GR - R56MH129437/MH/NIMH NIH HHS/United States GR - R01 MH118278/MH/NIMH NIH HHS/United States GR - R01 MH120170/MH/NIMH NIH HHS/United States GR - R01 MH124871/MH/NIMH NIH HHS/United States GR - R01MH119084/MH/NIMH NIH HHS/United States GR - R01MH124871/MH/NIMH NIH HHS/United States GR - 2021-00660/Fredrik och Ingrid Thurings Stiftelse/ GR - PG-22-0478/Svenska Sallskapet for Medicinsk Forskning/ GR - R01 MH136149/MH/NIMH NIH HHS/United States GR - R01MH120170/MH/NIMH NIH HHS/United States GR - R56 MH129437/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. DEP - 20250312 PL - England TA - J Child Psychol Psychiatry JT - Journal of child psychology and psychiatry, and allied disciplines JID - 0375361 SB - IM UOF - medRxiv. 2024 May 16:2024.05.16.24307471. doi: 10.1101/2024.05.16.24307471. PMID: 38798326 MH - Humans MH - Sweden/epidemiology MH - Child MH - Male MH - Female MH - *Neurodevelopmental Disorders/epidemiology MH - *Avoidant Restrictive Food Intake Disorder/epidemiology MH - Comorbidity MH - *Registries/statistics & numerical data MH - *Attention Deficit Disorder with Hyperactivity/epidemiology MH - Phenotype MH - *Attention Deficit and Disruptive Behavior Disorders/epidemiology PMC - PMC12350820 OTO - NOTNLM OT - Comorbidity OT - anxiety OT - autism OT - eating disorders OT - food fussiness OT - mental health EDAT- 2025/03/13 00:33 MHDA- 2025/08/31 19:51 PMCR- 2025/08/14 CRDT- 2025/03/12 22:03 PHST- 2024/12/13 00:00 [accepted] PHST- 2025/08/31 19:51 [medline] PHST- 2025/03/13 00:33 [pubmed] PHST- 2025/03/12 22:03 [entrez] PHST- 2025/08/14 00:00 [pmc-release] AID - JCPP14134 [pii] AID - 10.1111/jcpp.14134 [doi] PST - ppublish SO - J Child Psychol Psychiatry. 2025 Sep;66(9):1333-1344. doi: 10.1111/jcpp.14134. Epub 2025 Mar 12. PMID- 40074305 OWN - NLM STAT- MEDLINE DCOM- 20250512 LR - 20250512 IS - 1672-7347 (Print) IS - 1672-7347 (Linking) VI - 49 IP - 10 DP - 2024 Oct 28 TI - Agreement analysis of subjective and objective sleep quality in adolescents with mood disorders. PG - 1566-1575 LID - 1672-7347(2024)10-1566-10 [pii] LID - 10.11817/j.issn.1672-7347.2024.240346 [doi] AB - OBJECTIVES: Accurate assessment of sleep quality is crucial for understanding sleep problems and their impact on health. This study analyzed the agreement between subjective sleep assessments and objective sleep monitoring in adolescents with mood disorders, aiming to provide a reliable methodological foundation for related research. METHODS: Adolescents with mood disorders were recruited from psychiatric outpatient clinics of three domestic hospitals. A consensus sleep diary and an actigraph (activity tracker) were used to monitor sleep for 14 days. The differences between subjective and objective measurements were compared using the Wilcoxon signed-rank test, while Bland-Altman plots and intraclass correlation coefficients (ICC), described their agreement. Spearman's rank correlation coefficients were used to assess their correlation, and mixed-effects models analyzed factors influencing the differences between subjective and objective measurements. RESULTS: Significant differences were observed between subjective and objective measures for the number of awakenings after sleep onset (NWAK), waking after sleep onset (WASO), total sleep time (TST), and wake-up time (P<0.001); however, the difference in sleep onset time was not statistically significant (P=0.283). Subjective and objective measurements of sleep onset (ICC=0.821, r=0.838) and wake-up time (ICC=0.821, r=0.836) demonstrated good agreement and correlation; TST showed moderate agreement (ICC=0.640) and correlation (r=0.682); NWAK (ICC=0.210, r=0.276) and WASO (ICC=0.358, r=0.365) exhibited poor and correlation. In the Bland-Altman plots, most data points for sleep onset, wake-up time, and TST were uniformly distributed within the 95% limits of agreement (LoA). The differences between subjective and objective measurements for WASO and NWAK increased with higher average values. However, the 95% LoA of the differences between subjective and objective measurements of all the above indicators exceeded the acceptable ranges of the corresponding indicators, indicating poor agreement. Baseline depression levels were associated with the differences between subjective and objective measurements of NWAK (beta=0.034, P<0.05), TST (beta=2.617, P<0.01), and sleep onset (beta=1.454, P<0.05), while sleep quality scores were associated with the difference in WASO (beta=0.051, P<0.01). CONCLUSIONS: Considerable discrepancies remain between subjective sleep diaries and sleep monitoring data from actigraphy (activity tracker). Future research should further investigate factors influencing the discrepancies between subjective and objective measurements and refine measurement methods to obtain more reliable sleep data. FAU - Chen, Tengwei AU - Chen T AD - Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha 410013. t379716620@163.com. FAU - Niu, Lu AU - Niu L AD - Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha 410013. niu_lu@csu.edu.cn. FAU - Zhu, Jiaxin AU - Zhu J AD - Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha 410013. FAU - Qiu, Dan AU - Qiu D AD - Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha 410013. FAU - Zhang, Chengcheng AU - Zhang C AD - Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha 410013. FAU - Chen, Yuedong AU - Chen Y AD - Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha 410013. FAU - Zhang, Honghui AU - Zhang H AD - Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha 410013. FAU - Hou, Xiaofei AU - Hou X AD - Department of Community Prevention, Tianjin Anding Hospital, Tianjin 300222. FAU - Tao, Haojuan AU - Tao H AD - Department of Psychiatry, Second Xiangya Hospital, Central South University; National Clinical Research Center on Mental Disorders, Changsha 410011. FAU - Chen, Xiyuan AU - Chen X AD - Department of Community Psychiatry, Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370. FAU - Ma, Yarong AU - Ma Y AD - Department of Psychosomatic Medicine, Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370. FAU - Lin, Kangguang AU - Lin K AD - Department of Mood Disorders, Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370. AD - School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao Shandong 266113, China. FAU - Zhou, Liang AU - Zhou L AD - Department of Community Psychiatry, Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370. LA - eng LA - chi GR - 21-425/the grant from China Medical Board, USA/ PT - Journal Article TT - 心境障碍青少年主客观睡眠质量的一致性分析. PL - China TA - Zhong Nan Da Xue Xue Bao Yi Xue Ban JT - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences JID - 101230586 SB - IM MH - Humans MH - Adolescent MH - *Sleep Quality MH - Actigraphy MH - Male MH - *Mood Disorders/physiopathology MH - Female MH - *Sleep/physiology MH - *Sleep Wake Disorders MH - Surveys and Questionnaires PMC - PMC11897964 OAB - OBJECTIVE: Accurate assessment of sleep quality is crucial for understanding sleep problems and their impact on health. This study analyzed the agreement between subjective sleep assessments and objective sleep monitoring in adolescents with mood disorders, aiming to provide a reliable methodological foundation for related research. METHODS: Adolescents with mood disorders were recruited from psychiatric outpatient clinics of three domestic hospitals. A consensus sleep diary and an actigraph (activity tracker) were used to monitor sleep for 14 days. The differences between subjective and objective measurements were compared using the Wilcoxon signed-rank test, while Bland-Altman plots and intraclass correlation coefficients (ICC), described their agreement. Spearman's rank correlation coefficients were used to assess their correlation, and mixed-effects models analyzed factors influencing the differences between subjective and objective measurements. RESULTS: Significant differences were observed between subjective and objective measures for the number of awakenings after sleep onset (NWAK), waking after sleep onset (WASO), total sleep time (TST), and wake-up time (P<0.001); however, the difference in sleep onset time was not statistically significant (P=0.283). Subjective and objective measurements of sleep onset (ICC=0.821, r=0.838) and wake-up time (ICC=0.821, r=0.836) demonstrated good agreement and correlation; TST showed moderate agreement (ICC=0.640) and correlation (r=0.682); NWAK (ICC=0.210, r=0.276) and WASO (ICC=0.358, r=0.365) exhibited poor and correlation. In the Bland-Altman plots, most data points for sleep onset, wake-up time, and TST were uniformly distributed within the 95% limits of agreement (LoA). The differences between subjective and objective measurements for WASO and NWAK increased with higher average values. However, the 95% LoA of the differences between subjective and objective measurements of all the above indicators exceeded the acceptable ranges of the corresponding indicators, indicating poor agreement. Baseline depression levels were associated with the differences between subjective and objective measurements of NWAK (beta=0.034, P<0.05), TST (beta=2.617, P<0.01), and sleep onset (beta=1.454, P<0.05), while sleep quality scores were associated with the difference in WASO (beta=0.051, P<0.01). CONCLUSION: Considerable discrepancies remain between subjective sleep diaries and sleep monitoring data from actigraphy (activity tracker). Future research should further investigate factors influencing the discrepancies between subjective and objective measurements and refine measurement methods to obtain more reliable sleep data. OABL- eng OTO - NOTNLM OT - actigraphy OT - adolescents OT - agreement OT - correlation OT - influencing factors OT - mood disorder OT - sleep diary COIS- 作者声称无任何利益冲突。 EDAT- 2025/03/13 00:33 MHDA- 2025/03/13 00:34 PMCR- 2024/10/28 CRDT- 2025/03/12 21:12 PHST- 2025/03/13 00:34 [medline] PHST- 2025/03/13 00:33 [pubmed] PHST- 2025/03/12 21:12 [entrez] PHST- 2024/10/28 00:00 [pmc-release] AID - 1672-7347(2024)10-1566-10 [pii] AID - 10.11817/j.issn.1672-7347.2024.240346 [doi] PST - ppublish SO - Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2024 Oct 28;49(10):1566-1575. doi: 10.11817/j.issn.1672-7347.2024.240346. PMID- 40074244 OWN - NLM STAT- MEDLINE DCOM- 20250312 LR - 20260518 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 9 IP - 1 DP - 2025 Mar 12 TI - Artificial intelligence for weight estimation in paediatric emergency care. LID - 10.1136/bmjpo-2024-002891 [doi] LID - e002891 AB - OBJECTIVE: To develop and validate a paediatric weight estimation model adapted to the characteristics of the Spanish population as an alternative to currently extended methods. METHODS: Anthropometric data in a cohort of 11 287 children were used to develop machine learning models to predict weight using height and the body mass index (BMI) quartile (as surrogate for body habitus (BH)). The models were later validated in an independent cohort of 780 children admitted to paediatric emergencies in two other hospitals. The proportion of patients with a given absolute percent error (APE) was calculated for various APE thresholds and compared with the available weight estimation methods to date. The concordance between the BMI-based BH and the visual assessment was evaluated, and the effect of the visual estimation of the BH was assessed in the performance of the model. RESULTS: The machine learning model with the highest accuracy was selected as the final algorithm. The model estimates weight from the child's height and BH (under-, normal- and overweight) based on a support vector machine with a Gaussian-kernel (SVM-G). The model presented an APE<10% and <20% for 74.7% and 96.7% of the children, outperforming other available predictive formulas by 3.2-37.5% and 1.3-29.1%, respectively. Low concordance was observed between the theoretical and visually assessed BH in 36.7% of the children, showing larger errors in children under 2 years. CONCLUSIONS: The proposed SVM-G is a valid and safe tool to estimate weight in paediatric emergencies, more accurate than other local and global proposals. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Isasi, Iraia AU - Isasi I AUID- ORCID: 0000-0002-0312-4469 AD - Applied Mathematics, University of the Basque Country Bilbao School of Engineering, Bilbao, Spain iraia.isasi@ehu.eus. AD - Biocruces Bizkaia Health Research Institute, Barakaldo, Pais Vasco, Spain. FAU - Aramendi, Elisabete AU - Aramendi E AD - Biocruces Bizkaia Health Research Institute, Barakaldo, Pais Vasco, Spain. AD - Communications Engineering, University of the Basque Country Bilbao School of Engineering, Bilbao, Pais Vasco, Spain. FAU - Alonso, Erik AU - Alonso E AD - Applied Mathematics, University of the Basque Country Bilbao School of Engineering, Bilbao, Spain. AD - Biocruces Bizkaia Health Research Institute, Barakaldo, Pais Vasco, Spain. FAU - Ballesteros-Pena, Sendoa AU - Ballesteros-Pena S AD - Biocruces Bizkaia Health Research Institute, Barakaldo, Pais Vasco, Spain. CN - WEST research group LA - eng PT - Journal Article PT - Validation Study DEP - 20250312 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Child MH - Male MH - *Body Weight MH - Female MH - Child, Preschool MH - Body Mass Index MH - *Artificial Intelligence MH - *Machine Learning MH - Infant MH - Spain MH - *Emergency Medical Services/methods MH - Adolescent MH - *Anthropometry/methods PMC - PMC11907021 OTO - NOTNLM OT - Child Health OT - Machine Learning OT - Resuscitation COIS- Competing interests: No, there are no competing interests. FIR - Aedo, Irrintzi Fernandez IR - Aedo IF FIR - Hoz, Gorka Vallejo De la IR - Hoz GV FIR - Llarena, Garbine Perez IR - Llarena GP FIR - Lastra, Irantzu Echeandia IR - Lastra IE FIR - Zarandona, Ines Ercoreca IR - Zarandona IE FIR - Villa, M Inmaculada Polanco IR - Villa MIP FIR - Soriano, Laura Arranz IR - Soriano LA FIR - Lamas, Laura Folgueira IR - Lamas LF FIR - Santos, Maider Etxeandia IR - Santos ME FIR - Manzanos, M Teresa Vime IR - Manzanos MTV FIR - Amayuelas, Nerea Fernandez IR - Amayuelas NF EDAT- 2025/03/13 00:33 MHDA- 2025/03/13 00:34 PMCR- 2025/03/12 CRDT- 2025/03/12 20:53 PHST- 2024/07/09 00:00 [received] PHST- 2025/02/17 00:00 [accepted] PHST- 2025/03/13 00:34 [medline] PHST- 2025/03/13 00:33 [pubmed] PHST- 2025/03/12 20:53 [entrez] PHST- 2025/03/12 00:00 [pmc-release] AID - 10.1136/bmjpo-2024-002891 [pii] AID - bmjpo-2024-002891 [pii] AID - 10.1136/bmjpo-2024-002891 [doi] PST - epublish SO - BMJ Paediatr Open. 2025 Mar 12;9(1):e002891. doi: 10.1136/bmjpo-2024-002891. PMID- 40072881 OWN - NLM STAT- MEDLINE DCOM- 20250606 LR - 20250624 IS - 1539-2570 (Electronic) IS - 0271-6798 (Linking) VI - 45 IP - 6 DP - 2025 Jul 1 TI - Validation of Parental Reports in Assessing Idiopathic Toe Walking Using Quantitative In-Shoe Device Measurements. PG - 306-311 LID - 10.1097/BPO.0000000000002950 [doi] AB - BACKGROUND: Toe walking is prevalent among children, affecting 5% to 24% of the pediatric population. Clinicians rely on parental reports of frequency of toe walking to guide clinical decision making and outcomes assessment. However, recall accuracy and differing environments challenge the reliability of parental reports. This study aims to validate parental reports against quantitative in-shoe device measurements (NURVV/RUN). METHODS: Twenty children with persistent idiopathic toe walking (ITWp) (mean age: 9.6y; 13 males, 7 females) from 8 pediatric orthopaedic specialty care sites participated in this multicenter study. Parents assessed toe walking frequency using a 6-point scale, while children wore NURVV/RUN insoles for 8 hours/day over 7 days. Insole sensors recorded foot strike patterns (rearfoot, midfoot, and forefoot), which were classified using the same severity scale. Agreement between parental reports and NURVV data was assessed using weighted Kappa statistics ( P <0.05). RESULTS: Before intervention, children with ITWp exhibited daily walking patterns: 61.7% forefoot, 15.3% midfoot, and 22.8% hindfoot contact. Agreement analysis showed substantial agreement (k=0.688, P <0.001) for combined forefoot and midfoot contacts and fair agreement (k=0.381, P <0.005) for isolated forefoot contact. CONCLUSION: Parental reports of toe walking prevalence in their children are relatively accurate, supporting their use in clinical management. However, quantitative in-shoe devices provide a more objective and quantitative understanding of ITWp frequency and have the potential to guide clinical decision-making and outcomes assessment children with ITWp. LEVEL OF EVIDENCE: Level II-diagnostic study. See instructions to authors for a complete description of levels of evidence. CI - Copyright (c) 2025 Wolters Kluwer Health, Inc. All rights reserved. FAU - Morrison, Logan AU - Morrison L AUID- ORCID: 0009-0006-2435-696 AD - Shriners Children's Portland, Portland, OR. AD - A.T. Still University School of Osteopathic Medicine in Arizona, Mesa, AZ. FAU - Sienko, Susan AU - Sienko S AD - Shriners Children's Portland, Portland, OR. FAU - McMulkin, Mark AU - McMulkin M AD - Shriners Children's Spokane, Spokane, WA. FAU - MacWilliams, Bruce AU - MacWilliams B AD - Shriners Children's Salt Lake City, Salt Lake City, UT. FAU - Davids, Jon AU - Davids J AD - Shriners Children's Northern California, Sacramento. FAU - Lemhouse, Paige AU - Lemhouse P AD - Shriners Children's Portland, Portland, OR. FAU - Bauer, Jeremy AU - Bauer J AD - Shriners Children's Portland, Portland, OR. CN - Shriners Children's ITW Research Group LA - eng GR - 79144/Helen Lemieux Research Fund/ PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20250312 PL - United States TA - J Pediatr Orthop JT - Journal of pediatric orthopedics JID - 8109053 SB - IM MH - Humans MH - Male MH - Female MH - Child MH - *Walking/physiology MH - *Parents MH - *Toes/physiopathology/physiology MH - *Shoes MH - Reproducibility of Results MH - Adolescent MH - *Gait/physiology MH - Foot Orthoses OTO - NOTNLM OT - gait OT - idiopathic toe walking OT - in-shoe devices OT - parental reporting OT - toe walking COIS- The authors declare no conflicts of interest. EDAT- 2025/03/12 18:17 MHDA- 2025/06/06 18:31 CRDT- 2025/03/12 12:31 PHST- 2025/06/06 18:31 [medline] PHST- 2025/03/12 18:17 [pubmed] PHST- 2025/03/12 12:31 [entrez] AID - 01241398-202507000-00013 [pii] AID - 10.1097/BPO.0000000000002950 [doi] PST - ppublish SO - J Pediatr Orthop. 2025 Jul 1;45(6):306-311. doi: 10.1097/BPO.0000000000002950. Epub 2025 Mar 12. PMID- 40072628 OWN - NLM STAT- MEDLINE DCOM- 20250513 LR - 20261008 IS - 1248-9204 (Electronic) IS - 1248-9204 (Linking) VI - 29 IP - 1 DP - 2025 Mar 12 TI - Balloon dissection for robotic totally extra-peritoneal (rTEP) inguinal herniorrhaphy: description of a modified technique and report on 97 consecutive patients. PG - 115 LID - 10.1007/s10029-025-03312-z [doi] AB - PURPOSE: As the use of robotic platforms for inguinal hernia repairs continues to grow, the rTAPP (Robotic Trans-Abdominal Pre-Peritoneal) approach is being performed significantly more often than rTEP (Robotic Totally Extra-Peritoneal) and is predominantly taught to newly trained robotic surgeons. This study's primary objective was to evaluate the feasibility of a proposed modified rTEP technique that incorporates balloon dissection as a primary tool, enabling the horizontal placement of three trocars aligned with the umbilicus. Secondary objectives included evaluation of safety and effectiveness of this technique, and of the learning curve required to reach proficiency. METHODS: From February 2023 to April 2024, a total of 97 consecutive patients (87 males, 10 females) with an average age of 61 years (range 17-89) and a mean body mass index of 26 kg/m(2) (21-37) underwent rTEP for the repair of 122 inguinal and femoral hernias. All procedures were performed by a single surgeon following a standardized protocol detailed in this manuscript. Key metrics and events assessed included conversions to open or laparoscopic approaches, console operating times, postoperative narcotic usage, postoperative complications, serious adverse events, unplanned returns to the operating room within 30 days, and hernia recurrences. Cumulative sum (CUSUM)_sequential analysis was used for determination of the learning curve. RESULTS: Repaired hernias included 57 indirect (46.7%), 48 direct (39.3%), 4 femoral (3.3%) and 13 mixed (10.7%). There were no conversions to open or laparoscopic surgery, and the average console time was 45 min for unilateral repairs and 68 min for bilateral repairs. 70% of patients elected not to use the narcotic prescribed for postoperative analgesia. There was one serious adverse event (1/97, 1.0%), and one unplanned return to the operating room within 30 days (1/97, 1.0%). Over an average follow-up period of 52 weeks (range 25-87 weeks), there was one recurrence (1/122, 0.8%). In our analysis of the learning curve, we found that proficiency was reached around the 24th non-complex unilateral case. CONCLUSION: The modified rTEP technique utilizing balloon dissection is feasible, reproducible and time efficient. This study demonstrates its safety and effectiveness. The technique provides superior visualization of the extraperitoneal space, facilitates manipulation of robotic wristed instruments, and ensures proper mesh placement. Early postoperative outcomes suggest that rTEP could play an important role in the surgical management of inguinal and femoral hernias. Further studies are needed to provide data on short and long-term quality of life, and to compare rTEP to rTAPP. CI - (c) 2025. The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature. FAU - Trad, Karim S AU - Trad KS AUID- ORCID: 0000-0002-9149-707X AD - Division of General Surgery, Georgetown University School of Medicine, Washington, DC, USA. karimsamitrad@gmail.com. AD - Department of General Surgery, MedStar Georgetown University Hospital, Washington, DC, USA. karimsamitrad@gmail.com. FAU - Thiru, Shankar S AU - Thiru SS AD - Georgetown University School of Medicine, Washington, DC, USA. FAU - Stirrat, Thomas P AU - Stirrat TP AD - Georgetown University School of Medicine, Washington, DC, USA. FAU - Marino, Paul J AU - Marino PJ AD - Department of General Surgery, MedStar Georgetown University Hospital, Washington, DC, USA. FAU - Prevou, Elizabeth R AU - Prevou ER AD - The George Washington University School of Medicine & Health Sciences, Washington, DC, USA. FAU - Greer, Margaret E AU - Greer ME AD - Georgetown University School of Medicine, Washington, DC, USA. FAU - Alimi, Yewande R AU - Alimi YR AD - Department of General Surgery, MedStar Georgetown University Hospital, Washington, DC, USA. LA - eng PT - Journal Article DEP - 20250312 PL - France TA - Hernia JT - Hernia : the journal of hernias and abdominal wall surgery JID - 9715168 SB - IM MH - Humans MH - Male MH - Middle Aged MH - *Hernia, Inguinal/surgery MH - *Robotic Surgical Procedures/methods/adverse effects/education MH - Female MH - Adult MH - Aged MH - *Herniorrhaphy/methods MH - Aged, 80 and over MH - Adolescent MH - Young Adult MH - Feasibility Studies MH - Learning Curve MH - *Dissection/methods MH - Postoperative Complications/epidemiology MH - Operative Time OTO - NOTNLM OT - Balloon dissector OT - Inguinal hernia OT - Robotic herniorrhaphy OT - Totally extraperitoneal surgery OT - rTEP COIS- Declarations. IRB: IRB approval was obtained for this study from Georgetown University (IRB Study #: 00007926). Disclaimers: None. Competing interests: All authors of this study have no competing interests to disclose. EDAT- 2025/03/12 18:17 MHDA- 2025/03/12 18:18 CRDT- 2025/03/12 12:19 PHST- 2024/11/26 00:00 [received] PHST- 2025/03/01 00:00 [accepted] PHST- 2025/03/12 18:18 [medline] PHST- 2025/03/12 18:17 [pubmed] PHST- 2025/03/12 12:19 [entrez] AID - 10.1007/s10029-025-03312-z [pii] AID - 10.1007/s10029-025-03312-z [doi] PST - epublish SO - Hernia. 2025 Mar 12;29(1):115. doi: 10.1007/s10029-025-03312-z. PMID- 40071597 OWN - NLM STAT- MEDLINE DCOM- 20250710 LR - 20250710 IS - 1753-4887 (Electronic) IS - 0029-6643 (Linking) VI - 83 IP - 8 DP - 2025 Aug 1 TI - Psychometric Properties of Questionnaires to Assess the Family Food Environment in the Pediatric Population: A Systematic Review. PG - 1494-1519 LID - 10.1093/nutrit/nuaf018 [doi] AB - CONTEXT: Given the diverse aspects of the family food environment, it is essential to clarify the availability of tools, the assessed dimensions, and the extent to which they offer a comprehensive and valid evaluation of the domestic food setting. OBJECTIVE: This systematic review aims to assess the validity and reliability of instruments gauging the food environment within the pediatric population. DATA SOURCES: A systematic literature search was conducted in the EMBASE, Medline (PubMed), SCOPUS, Web of Science, and PsychINFO databases until December 2023, resulting in the identification of 2850 potentially eligible articles. DATA EXTRACTION: After a thorough screening process, comprising language and title criteria, abstract scrutiny, and full-text reading, 179 full papers were separately reviewed, and 52 were chosen for analysis. DATA ANALYSIS: Predominantly conducted in the United States utilizing adapted tools, the investigations focused on the sociocultural environment as the most addressed domain. It covered 80.7% of instruments for children and 54.9% for adolescents. The prevailing reliability assessment method was internal consistency, using Cronbach's alpha-coefficient. Acceptable values ranged from 0.70 to 0.96 for children and 0.77 to 0.94 for adolescents. Out of the 52 studies selected, only 22 presented validity measures, with a primary focus on convergent and construct validity assessed through Pearson or Spearman correlation. The findings indicate that, while questionnaires assessing the family food environment exhibited acceptable reliability, validity measures were deemed limited and somewhat ambiguous. CONCLUSION: Given the pivotal role of validity in evaluating methodological accuracy and relevance, particularly when measuring specific aspects, there is an imperative need to develop instruments that integrate robust validity measures for the comprehensive assessment of the family food environment. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42022333228. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Souza, Leticia Gabrielle AU - Souza LG AUID- ORCID: 0000-0003-0098-5607 AD - Faculty of Public Health, Department of Epidemiology, University of Sao Paulo, Sao Paulo, SP 01246-904, Brazil. FAU - De Araujo-Moura, Keisyanne AU - De Araujo-Moura K AUID- ORCID: 0000-0003-1022-1950 AD - Faculty of Public Health, Department of Epidemiology, University of Sao Paulo, Sao Paulo, SP 01246-904, Brazil. FAU - Ferreira De Moraes, Augusto Cesar AU - Ferreira De Moraes AC AUID- ORCID: 0000-0002-5763-435X AD - Department of Epidemiology of the School of Public Health in Austin, The University of Texas Health Science Center at Houston (UTHealth Houston), Austin, TX 78701, United States. LA - eng GR - 88887.700710/2022-00/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ PT - Journal Article PT - Systematic Review PL - United States TA - Nutr Rev JT - Nutrition reviews JID - 0376405 SB - IM MH - Humans MH - *Psychometrics MH - Child MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - Adolescent MH - *Family/psychology OTO - NOTNLM OT - family food environment OT - home food environment OT - pediatric population OT - psychometric properties EDAT- 2025/03/12 12:31 MHDA- 2025/07/10 06:27 CRDT- 2025/03/12 06:53 PHST- 2025/07/10 06:27 [medline] PHST- 2025/03/12 12:31 [pubmed] PHST- 2025/03/12 06:53 [entrez] AID - 8071444 [pii] AID - 10.1093/nutrit/nuaf018 [doi] PST - ppublish SO - Nutr Rev. 2025 Aug 1;83(8):1494-1519. doi: 10.1093/nutrit/nuaf018. PMID- 40071119 OWN - NLM STAT- MEDLINE DCOM- 20250513 LR - 20250513 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - A novel Adolescent Health Behavior Checklist. PG - 1438775 LID - 10.3389/fpubh.2025.1438775 [doi] LID - 1438775 AB - PURPOSE: Adolescents are experiencing rising rates of obesity, insufficient exercise, and sleep disorders. To provide a scientific basis for policymakers to develop targeted and evidence-based health behavior education and policies, this study employed structural equation modeling to design the Adolescent Health Behavior Checklist (AHBC). METHODS: We designed a draft 6-dimensional AHBC, which includes the dimensions of exercise, diet, personal responsibility, sleep, interpersonal relationships, and stress management. Each item is rated on a 5-point Likert scale, with higher scores indicating healthier behavior. Through exploratory factor analysis (EFA) and confirmatory factor analysis (CFA), we optimized the construct validity of the AHBC. RESULTS: The optimal factor structure was first determined using EFA with 177 middle school students participating in the process. EFA suggested a hierarchical, 6-factor AHBC with good internal consistency (global Cronbach's alpha = 0.96). Using an independent sample of 349 middle school students, CFA confirmed the construct validity of the AHBC. The final model demonstrated a good fit: SRMR = 0.058, CFI = 0.990. Five out of six latent variables had factor loadings higher than 0.7, and 81% of the item-level factor loadings exceeded 0.7. Additionally, all latent variables had McDonald's omega values higher than 0.7, indicating acceptable convergent validity. Finally, factor correlations showed that the AHBC has good discriminant validity. CONCLUSIONS: The AHBC is a 31-item checklist that assesses adolescents' all-around health behaviors, using a score of four as the benchmark value. The shortcomings of the current checklist are discussed, along with future theoretical and practical directions for improvement. CI - Copyright (c) 2025 Su, Bai, Li and Zhang. FAU - Su, Yanjie AU - Su Y AD - School of Sport Education, Tianjin University of Sport, Tianjin, China. FAU - Bai, Hua AU - Bai H AD - College of Physical Education, Xingtai University, Xingtai, China. FAU - Li, Ying AU - Li Y AD - School of Sport Education, Tianjin University of Sport, Tianjin, China. FAU - Zhang, Yang AU - Zhang Y AD - Independent Researcher, Windermere, FL, United States. LA - eng PT - Journal Article DEP - 20250225 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Adolescent MH - *Checklist/standards MH - *Health Behavior MH - Female MH - Male MH - *Adolescent Behavior/psychology MH - Factor Analysis, Statistical MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Exercise PMC - PMC11893397 OTO - NOTNLM OT - health literacy OT - mental health OT - nutrition OT - physical activity OT - sleep COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/03/12 11:35 MHDA- 2025/03/12 11:36 PMCR- 2025/02/25 CRDT- 2025/03/12 04:44 PHST- 2024/05/26 00:00 [received] PHST- 2025/02/06 00:00 [accepted] PHST- 2025/03/12 11:36 [medline] PHST- 2025/03/12 11:35 [pubmed] PHST- 2025/03/12 04:44 [entrez] PHST- 2025/02/25 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1438775 [doi] PST - epublish SO - Front Public Health. 2025 Feb 25;13:1438775. doi: 10.3389/fpubh.2025.1438775. eCollection 2025. PMID- 40068087 OWN - NLM STAT- MEDLINE DCOM- 20250311 LR - 20250512 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 104 IP - 10 DP - 2025 Mar 7 TI - Psychometric validation of the belief-based physical activity questionnaire. PG - e41764 LID - 10.1097/MD.0000000000041764 [doi] LID - e41764 AB - This study aimed to develop and validate the belief-based PA questionnaire for young Saudi females (BPAQ-YSF) in Saudi Arabia, targeting women aged 18 to 35. Six experts first participated in the conceptual validation phase, while 8 reviewed the content validity. Cross-sectional validation was carried out using a test-retest design. The study is a self-report instrument that consists of 4 parts. Each part examines various variables. The cross-sectional validation part of the study presents the results of the cross-sectional validation of the theory of planned behavior (TPB) among 820 Saudi female participants aged 18 to 35. The psychometric properties of the TPB were measured using adopted scales of direct and additional constructs, and the Cronbach alpha values indicated that the scales could deliver reliable results in a cross-cultural setting. Principal axis factoring was conducted on 24 items with oblique rotation to assess the 8 factors of the extended TPB, and the 8-factor structure explained a total variance of 76.6%. The BPAQ-YSF can help identify the psychosocial factors related to physical activity among young Saudi women. The study's findings can inform the development of interventions and culturally appropriate guidelines for PA among young Saudi women. CI - Copyright (c) 2025 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Alharbi, Basmah F AU - Alharbi BF AD - Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Almulaida, Saudi Arabia. FAU - Baker, Philip R A AU - Baker PRA AD - Faculty of Health, School of Public Health and Social Work, Queensland University of Technology, Kelvin Grove, QLD, Australia. FAU - Pavey, Toby G AU - Pavey TG AD - Faculty of Health, School of Exercise and Nutrition Sciences, Queensland University of Technology, Kelvin Grove, QLD, Australia. FAU - Alharbi, Manal F AU - Alharbi MF AUID- ORCID: 0000-0001-6630-7476 AD - Maternal & Child Health Nursing Department, College of Nursing, King Saud University, Riyadh, Kingdom of Saudi Arabia. LA - eng PT - Journal Article PT - Validation Study PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Female MH - Psychometrics MH - Saudi Arabia MH - Adult MH - Cross-Sectional Studies MH - *Exercise/psychology MH - Adolescent MH - Young Adult MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Self Report PMC - PMC11903021 COIS- There are no conflicts of interest relevant to the content of this paper. EDAT- 2025/03/12 11:33 MHDA- 2025/03/12 11:34 PMCR- 2025/03/07 CRDT- 2025/03/11 15:43 PHST- 2025/03/12 11:34 [medline] PHST- 2025/03/12 11:33 [pubmed] PHST- 2025/03/11 15:43 [entrez] PHST- 2025/03/07 00:00 [pmc-release] AID - 00005792-202503070-00068 [pii] AID - MD-D-23-09264 [pii] AID - 10.1097/MD.0000000000041764 [doi] PST - ppublish SO - Medicine (Baltimore). 2025 Mar 7;104(10):e41764. doi: 10.1097/MD.0000000000041764. PMID- 40067779 OWN - NLM STAT- MEDLINE DCOM- 20250702 LR - 20251021 IS - 1536-3724 (Electronic) IS - 1050-642X (Print) IS - 1050-642X (Linking) VI - 35 IP - 4 DP - 2025 Mar 11 TI - Phenotype of Achilles Tendon Ultrasonographic Abnormalities and Their Relationship to Future Time-Loss Injury. PG - 505-507 LID - 10.1097/JSM.0000000000001342 [doi] AB - OBJECTIVE: To identify specific tendon morphologies on ultrasonography of the Achilles tendon (AT) that later develop time-loss injury. DESIGN: Blinded post hoc analysis of a 2-year prospective, observational study of 944 AT sonographic videos to identify morphologic characteristics of diagnosed Achilles tendinopathies associated with future time-loss injury. The second year was used to validate the findings from the first year. SETTING: N/A. PATIENTS/PARTICIPANTS: Four hundred seventy-three National Collegiate Athletic Association student-athletes from 3 institutions over 2 years of data collection (57.7% females; 20.1 +/- 1.6 years of age; 23.1 +/- 2.8 kg/m 2 of body mass index; 9.4 +/- 3.6 years of sport experience). INTERVENTIONS/ASSESSMENT OF RISK FACTORS: Particular tendon morphologies were used to develop 3 ultrasonographic imaging rules that were used to predict AT injury leading to time loss in sport. MAIN OUTCOME MEASURES: Positive predictive value (PPV) and negative predictive values of particular tendon morphologies associated with the development of time-loss injury within 1 year. RESULTS: One of 3 morphologies, a deep mid-substance focal hypoechogenic area, was validated on 2 separate data sets and found to have a 33.3% PPV in both years for the development of time-loss injury. CONCLUSION: Results suggest a specific phenotype of sonographic abnormality of the AT that suggests a 1-in-3 chance of developing time-loss injury within a year. Detecting abnormality of future AT before symptoms develop may allow for rehabilitation strategies to prevent or reduce time-loss. CI - Copyright (c) 2025 Wolters Kluwer Health, Inc. All rights reserved. FAU - Cushman, Daniel M AU - Cushman DM AUID- ORCID: 0000-0002-4580-1173 AD - Department of Physical Medicine & Rehabilitation, University of Utah, Salt Lake City, Utah. AD - Department of Orthopaedics, University of Utah, Salt Lake City, Utah. FAU - Nowak, Andrew S AU - Nowak AS AD - Department of Physical Medicine and Rehabilitation, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; and. FAU - Cone Le Beaumont, W Reed AU - Cone Le Beaumont WR AD - University of Utah, Spencer Fox Eccles School of Medicine, Salt Lake City, Utah. FAU - Stokes, Derek AU - Stokes D AD - Department of Physical Medicine & Rehabilitation, University of Utah, Salt Lake City, Utah. LA - eng GR - UL1 TR002538/TR/NCATS NIH HHS/United States GR - UM1 TR004409/TR/NCATS NIH HHS/United States GR - UL1TR002538/PAC-12, National Center for Advancing Translational Sciences/ PT - Journal Article PT - Observational Study DEP - 20250311 PL - United States TA - Clin J Sport Med JT - Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine JID - 9103300 SB - IM MH - Humans MH - *Achilles Tendon/diagnostic imaging/injuries MH - Female MH - Prospective Studies MH - Male MH - Young Adult MH - Ultrasonography MH - *Athletic Injuries/diagnostic imaging MH - *Tendinopathy/diagnostic imaging MH - Phenotype MH - Risk Factors MH - Adolescent MH - Predictive Value of Tests PMC - PMC12535227 MID - NIHMS2117371 COIS- The authors report no conflicts of interest. EDAT- 2025/03/12 11:36 MHDA- 2025/07/02 12:30 PMCR- 2025/10/18 CRDT- 2025/03/11 13:21 PHST- 2024/07/14 00:00 [received] PHST- 2025/01/31 00:00 [accepted] PHST- 2025/07/02 12:30 [medline] PHST- 2025/03/12 11:36 [pubmed] PHST- 2025/03/11 13:21 [entrez] PHST- 2025/10/18 00:00 [pmc-release] AID - 00042752-202507000-00015 [pii] AID - 10.1097/JSM.0000000000001342 [doi] PST - epublish SO - Clin J Sport Med. 2025 Mar 11;35(4):505-507. doi: 10.1097/JSM.0000000000001342. PMID- 40066806 OWN - NLM STAT- MEDLINE DCOM- 20250730 LR - 20260422 IS - 1365-3016 (Electronic) IS - 0269-5022 (Print) IS - 0269-5022 (Linking) VI - 39 IP - 5 DP - 2025 Jul TI - Adolescent Risk Factors for Adult Pre-Pregnancy Obesity and High Gestational Weight Gain: A Longitudinal Study. PG - 430-442 LID - 10.1111/ppe.70007 [doi] AB - BACKGROUND: Risk factors during adolescence appear to shape adult health, but little is known about how they are associated with pregnancy health. OBJECTIVES: We aimed to assess whether a variety of adolescent risk factors with links to adult overweight or obesity are associated with pre-pregnancy obesity (Body Mass Index [BMI] >/= 30 kg/m(2)) and high gestational weight gain (GWG; > 0.5 SD for pre-pregnancy BMI category and gestational age) in a cohort of women participating since adolescence in a longitudinal cohort. METHODS: At age 11-18 years participants reported on adolescent risk factors (overweight or obesity, healthy and unhealthy home food availability, food insufficiency, family meals, depressive symptoms, body dissatisfaction, weight teasing, binge eating, unhealthy weight control behaviours and dieting). Twenty years later, participants reporting a live birth (n = 656) recalled their pre-pregnancy weight and total GWG. Modified Poisson regression models were used to estimate associations of each factor with pre-pregnancy obesity and high GWG, adjusting for sociodemographics. We used Multivariate Imputation by Chained Equations to account for outcome misclassification using internal validation data. RESULTS: Eighteen percent of the sample had pre-pregnancy obesity and 26% had high GWG. Adolescent overweight or obesity (RR = 4.98, 95% CI 3.27, 7.57), body dissatisfaction (RR = 1.99; 95% CI: 1.31, 3.03) and unhealthy weight control behaviours (RR = 1.70; 95% CI: 1.06, 2.74), among other factors, were associated with pre-pregnancy obesity risk. For high GWG, there were imprecise associations with adolescent overweight or obesity (RR = 1.57; 95% CI: 1.06, 2.31), binge eating (RR = 1.36; 95% CI: 0.77, 2.39) and unhealthy weight control behaviours (RR = 1.38; 95% CI: 0.84, 2.25), among others. CONCLUSIONS: Findings suggest that some risk markers for pre-pregnancy obesity (and possibly high GWG) may be apparent as early as adolescence. Supporting adolescent health and well-being might have a role in improving weight-related health in the perinatal period. CI - (c) 2025 The Author(s). Paediatric and Perinatal Epidemiology published by John Wiley & Sons Ltd. FAU - Mason, Susan M AU - Mason SM AUID- ORCID: 0000-0002-7635-9832 AD - Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA. FAU - Farkas, Kriszta AU - Farkas K AD - Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA. FAU - Bodnar, Lisa M AU - Bodnar LM AUID- ORCID: 0000-0001-9427-5467 AD - Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, USA. FAU - MacLehose, Richard F AU - MacLehose RF AD - Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA. FAU - Neumark-Sztainer, Dianne AU - Neumark-Sztainer D AD - Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA. LA - eng GR - R35 HL139853/HL/NHLBI NIH HHS/United States GR - R01 HL116892/HL/NHLBI NIH HHS/United States GR - P2C HD041023/HD/NICHD NIH HHS/United States GR - R01 HD090053/HD/NICHD NIH HHS/United States GR - National Institute of Child Health and Human Development/ PT - Journal Article DEP - 20250311 PL - England TA - Paediatr Perinat Epidemiol JT - Paediatric and perinatal epidemiology JID - 8709766 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Adolescent MH - *Gestational Weight Gain MH - Risk Factors MH - Longitudinal Studies MH - Body Mass Index MH - Child MH - *Pediatric Obesity/epidemiology MH - *Obesity/epidemiology MH - *Pregnancy in Adolescence MH - Body Image PMC - PMC12308630 MID - NIHMS2062792 OTO - NOTNLM OT - depressive symptoms OT - disordered eating OT - food insufficiency OT - gestational weight gain OT - life course epidemiology OT - maternal obesity COIS- The authors declare no conflicts of interest. EDAT- 2025/03/12 11:35 MHDA- 2025/07/30 06:30 PMCR- 2025/07/30 CRDT- 2025/03/11 07:03 PHST- 2025/02/10 00:00 [revised] PHST- 2024/09/05 00:00 [received] PHST- 2025/02/12 00:00 [accepted] PHST- 2025/07/30 06:30 [medline] PHST- 2025/03/12 11:35 [pubmed] PHST- 2025/03/11 07:03 [entrez] PHST- 2025/07/30 00:00 [pmc-release] AID - PPE70007 [pii] AID - 10.1111/ppe.70007 [doi] PST - ppublish SO - Paediatr Perinat Epidemiol. 2025 Jul;39(5):430-442. doi: 10.1111/ppe.70007. Epub 2025 Mar 11. PMID- 40065439 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250313 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 13 IP - 1 DP - 2025 Mar 10 TI - Psychometric properties of the Turkish version of the child food rejection scale. PG - 43 LID - 10.1186/s40337-025-01228-8 [doi] LID - 43 AB - BACKGROUND: While some children are open to trying new foods, many exhibit dislike or refusal when encountering them for the first time. These behaviors can be broadly characterized as food neophobia and pickiness, which are believed to be the primary forms of food rejection among children. Because there are differences between countries in early feeding practices and culinary traditions, culturally adapted scales are needed to measure these behaviors. This study aimed to (1) test the reliability and validity of the Turkish adaptation of the Child Food Rejection Scale (CFRS), and (2) examine patterns of food rejection and the correlations between scale scores and sociodemographic characteristics among Turkish children. METHODS: The validity of the CFRS translated into Turkish and cross-culturally adapted was assessed by content validity, construct validity, and convergent validity. Internal consistency was measured with Cronbach's alpha coefficient for the scale and its subdimensions. The scale reliability was also evaluated using test-retest reliability and several tests. RESULTS: Three hundred seventy-five primary caregivers (mainly mothers) of children aged 2 to 7 years were recruited through an online questionnaire. The results confirmed the psychometric soundness of the Turkish CFRS. Construct validity was supported by factor analysis (KMO coefficient = 0.852; Bartlett's sphericity test chi(2)=1301.580, p < 0.01), with two factors explaining 53.47% of the variance. Internal consistency was high (Cronbach's alpha = 0.838 for the total scale; alpha = 0.845 for neophobia, alpha = 0.600 for pickiness). Test-retest reliability (ICC = 0.770) indicated stability over time. Reliability was further supported by split-half reliability (Spearman-Brown coefficient = 0.749; Guttman split-half coefficient = 0.746), and the scale demonstrated additivity (Tukey's test F = 35.543, p /=32 weeks, low fetal motion severity, and stable gating signals (e.g., overall image quality for BMI <30 kg/m(2) vs >/=30 kg/m(2): 4.4+/-0.7 vs. 4.1+/-0.7, p<0.001). Supine positioning resulted in better overall image quality compared to the left lateral position (4.5+/-0.5 vs. 4.2+/-0.8, p=0.001). Breath-holds provided similar overall image quality but improved contour sharpness and reduced artifacts compared to free breathing (5 [4,5] vs. 4 [4,5], p=0.042; and 4 [3-5] vs. 4 [3-5], p=0.014, respectively). At 1.5T field strength, higher contrast and fewer artifacts were observed compared to 3T (5 [4,5] vs. 5 [4,5], p=0.041; and 4 [4,5] vs. 4 [3-5], p=0.010, respectively). Slice thickness showed no significant impact on image quality. CONCLUSION: Various factors (e.g. BMI) influence fetal cardiac cine MRI image quality. Understanding these factors may help achieving reliable examinations and better exploit the potential of fetal cardiac MRI in clinical routine. CI - Copyright (c) 2025 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Vollbrecht, Thomas M AU - Vollbrecht TM AD - Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, Germany; Quantitative Imaging Lab Bonn (QILaB), University Hospital Bonn, Bonn, Germany. FAU - Goncalves, Luis F AU - Goncalves LF AD - Department of Radiology, Phoenix Children's Hospital, Phoenix, Arizona, USA. FAU - Bardo, Dianna M E AU - Bardo DME AD - Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA. FAU - Hart, Christopher AU - Hart C AD - Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, Germany; Department of Pediatric Cardiology, University Hospital Bonn, Bonn, Germany. FAU - Boeth, Heide AU - Boeth H AD - Northh Medical, Hamburg, Germany. FAU - Barker, Alex J AU - Barker AJ AD - Department of Radiology, Section of Pediatric Radiology, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FAU - Friesen, Richard M AU - Friesen RM AD - Division of Cardiology, Heart Institute, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, USA. FAU - Luetkens, Julian A AU - Luetkens JA AD - Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, Germany; Quantitative Imaging Lab Bonn (QILaB), University Hospital Bonn, Bonn, Germany. Electronic address: julian.luetkens@ukbonn.de. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20250307 PL - England TA - J Cardiovasc Magn Reson JT - Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance JID - 9815616 SB - IM MH - Humans MH - *Magnetic Resonance Imaging, Cine MH - Female MH - Predictive Value of Tests MH - *Fetal Heart/diagnostic imaging/physiopathology MH - Pregnancy MH - *Heart Defects, Congenital/diagnostic imaging/physiopathology/embryology MH - Gestational Age MH - *Cardiac-Gated Imaging Techniques MH - Artifacts MH - *Ultrasonography, Doppler MH - Patient Positioning MH - *Ultrasonography, Prenatal MH - Reproducibility of Results MH - Retrospective Studies MH - Signal-To-Noise Ratio PMC - PMC12053712 OTO - NOTNLM OT - Congenital heart disease OT - Doppler US OT - Fetal cardiac MRI OT - Scan protocol COIS- Declaration of competing interests The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: H.B. is employed by Northh Medical, the company that markets the Doppler US device. H.B. was involved in the study organization, but had no access to the clinical or technical study data, nor any influence on the data analysis or interpretation. EDAT- 2025/03/09 15:11 MHDA- 2025/06/12 00:38 PMCR- 2025/03/07 CRDT- 2025/03/08 19:16 PHST- 2024/10/21 00:00 [received] PHST- 2025/02/12 00:00 [revised] PHST- 2025/03/03 00:00 [accepted] PHST- 2025/06/12 00:38 [medline] PHST- 2025/03/09 15:11 [pubmed] PHST- 2025/03/08 19:16 [entrez] PHST- 2025/03/07 00:00 [pmc-release] AID - S1097-6647(25)00037-7 [pii] AID - 101875 [pii] AID - 10.1016/j.jocmr.2025.101875 [doi] PST - ppublish SO - J Cardiovasc Magn Reson. 2025 Summer;27(1):101875. doi: 10.1016/j.jocmr.2025.101875. Epub 2025 Mar 7. PMID- 40056199 OWN - NLM STAT- MEDLINE DCOM- 20250723 LR - 20260602 IS - 1433-3023 (Electronic) IS - 0937-3462 (Print) IS - 0937-3462 (Linking) VI - 36 IP - 6 DP - 2025 Jun TI - Cross-Cultural Adaptation and Validation of the Portuguese Version of the "Australian Pelvic Floor Questionnaire". PG - 1255-1263 LID - 10.1007/s00192-025-06087-0 [doi] AB - INTRODUCTION AND HYPOTHESIS: Pelvic floor dysfunction (PFD) is a common problem that occurs among women and increases with age and weight. This study was aimed at cross-culturally adapting and validating the original version of the Australian Pelvic Floor Questionnaire (APFQ) into Portuguese. METHODS: The process of cultural and linguistic adaptation and validation followed the guidelines. The obtained Portuguese version was assessed by an expert panel of physiotherapists specialized in women's health. Women with pelvic floor dysfunction also participated in a cognitive pre-test (n = 9). A sample of 50 women with PFD completed the questionnaire to evaluate internal consistency, construct validity, reproducibility, floor/ceiling effects assessment, and standard error of measurement. Test-retest was assessed with a 2-week interval. The study was approved by the Ethics Commission and all participants signed an informed consent form. RESULTS: Fifty women with a mean age of 53.90 (+/- 18.57) years, BMI of 27.5 (+/- 4.2), 55.6% with a bachelor's degree, and all with at least one child, participated in the study. The psychometric properties of the APFQ showed a high Cronbach's alpha for the four domains: bladder (0.837), bowel and sexual function (0.756), pelvic organ prolapse (0.840), and total score (0.714). In terms of reproducibility, intraclass coefficient domain values ranged from 0.934 to 0.976, with a total score of 0.948. CONCLUSIONS: The APFQ was cultural and linguistically adapted and validated for Portuguese. The Portuguese version of the APFQ (APFQ_P) showed acceptable values of validity and good reliability. It can be used in both clinical evaluation and in research on pelvic floor dysfunction. CI - (c) 2025. The Author(s). FAU - Mesquita, Marina AU - Mesquita M AUID- ORCID: 0009-0001-5181-4827 AD - Alcoitao School of Health Sciences, Cascais, Portugal. FAU - Cavalheiro, Luis AU - Cavalheiro L AUID- ORCID: 0000-0003-3280-6968 AD - Coimbra Health School, Polytechnic University of Coimbra, Coimbra, Portugal. AD - Center for Health Studies and Research of University of Coimbra (CEISUC), Coimbra, Portugal. FAU - Ferreira, Pedro AU - Ferreira P AUID- ORCID: 0000-0002-9448-9542 AD - Center for Health Studies and Research of University of Coimbra (CEISUC), Coimbra, Portugal. AD - Faculty of Economics at the University of Coimbra, Center for Health Studies and Research of University of Coimbra, (CEISUC), Coimbra, Portugal. FAU - Goncalves, Rui Soles AU - Goncalves RS AUID- ORCID: 0000-0002-6118-0338 AD - Coimbra Health School, Polytechnic University of Coimbra, Coimbra, Portugal. AD - Center for Health Studies and Research of University of Coimbra (CEISUC), Coimbra, Portugal. FAU - Vicente, Sonia AU - Vicente S AUID- ORCID: 0000-0003-0526-0904 AD - Egas Moniz Center for Interdisciplinary Research (CiiEM), Caparica, Portugal. svicente@egasmoniz.edu.pt. AD - Egas Moniz School of Health and Science, Caparica, Portugal. svicente@egasmoniz.edu.pt. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250308 PL - England TA - Int Urogynecol J JT - International urogynecology journal JID - 101567041 SB - IM MH - Humans MH - Female MH - Middle Aged MH - Reproducibility of Results MH - *Pelvic Floor Disorders/diagnosis/psychology MH - Surveys and Questionnaires/standards MH - Adult MH - Psychometrics MH - Translations MH - Aged MH - Portugal MH - Australia MH - Cross-Cultural Comparison PMC - PMC12287125 OTO - NOTNLM OT - APFQ_P OT - Pelvic floor dysfunction OT - Portuguese instrument OT - Validation OT - Women's pelvic assessment instrument COIS- Declarations. Ethical Approval: The study was conducted in accordance with the Declaration of Helsinki and it was approved by the Alcoitao School of Health Ethics Committee (Process No. 15/2021). Conflicts of Interest: The authors declare no conflicts of interest. EDAT- 2025/03/09 15:08 MHDA- 2025/07/23 12:32 PMCR- 2025/03/08 CRDT- 2025/03/08 11:14 PHST- 2024/07/25 00:00 [received] PHST- 2025/01/31 00:00 [accepted] PHST- 2025/07/23 12:32 [medline] PHST- 2025/03/09 15:08 [pubmed] PHST- 2025/03/08 11:14 [entrez] PHST- 2025/03/08 00:00 [pmc-release] AID - 10.1007/s00192-025-06087-0 [pii] AID - 6087 [pii] AID - 10.1007/s00192-025-06087-0 [doi] PST - ppublish SO - Int Urogynecol J. 2025 Jun;36(6):1255-1263. doi: 10.1007/s00192-025-06087-0. Epub 2025 Mar 8. PMID- 40055917 OWN - NLM STAT- MEDLINE DCOM- 20260424 LR - 20260424 IS - 1476-8321 (Electronic) IS - 0887-0446 (Linking) VI - 41 IP - 5 DP - 2026 May TI - Validation of the 21-item Physical Activity and Leisure Motivation Scale (PALMS) among Finnish late adolescents. PG - 759-782 LID - 10.1080/08870446.2025.2476625 [doi] AB - OBJECTIVE: This multi-study investigation examined the validity of the Physical Activity and Leisure Motivation Scale (PALMS) among 16- to 18-year-old Finnish participants. Specifically, we examined factorial structure, reliability, measurement invariance, convergent and predictive validity in respect to reported physical activity. METHODS AND MEASURES: In Study 1, 285 participants completed the 40-item PALMS, and in Study 2, 638 adolescents completed a shorter measure derived from Study 1, along with the Behavioural Regulation in Sport Questionnaire (BRSQ). RESULTS: Factor analysis in Study 1 indicated that a short seven-factor measure, called PALMS-21, adequately captures adolescent participation motives. Study 2 demonstrated acceptable model fit (factor loadings >.30, RMSEA = .046, SRMR = .040), and reliability values above .740. Factor correlations between PALMS-21 and BRSQ supported convergent validity, with high positive correlations between enjoyment and intrinsic motivation. Measurement invariance was established across gender, age, and sport modality. Results showed evidence of predictive validity of the PALMS-21 in explaining variance in reported physical activity. Mediation analysis demonstrated a positive indirect effect from enjoyment to reported physical activity, via intention to be physically active. CONCLUSION: Taken together results suggest that the PALMS-21 is a valid and reliable measure of motives to engage in physical activity and sport. As such, the PALMS-21 could be used to provide personalized advice to individuals or to monitor the dynamics in participation motives over time, which could guide the development of effective interventions. FAU - Ruiz, Montse C AU - Ruiz MC AUID- ORCID: 0000-0002-1116-206X AD - Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland. FAU - Hassandra, Mary AU - Hassandra M AD - School Physical Education and Health, University of Thessaly, Trikala, Greece. FAU - Aypar, Ezgi AU - Aypar E AD - Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland. FAU - Knittle, Keegan AU - Knittle K AD - Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland. FAU - Tolvanen, Asko AU - Tolvanen A AD - Faculty of Education and Psychology, University of Jyvaskyla, Jyvaskyla, Finland. FAU - Robazza, Claudio AU - Robazza C AD - BIND-Behavioral Imaging and Neural Dynamics Center, Department of Medicine and Aging Sciences, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy. LA - eng PT - Journal Article PT - Validation Study DEP - 20250308 PL - England TA - Psychol Health JT - Psychology & health JID - 8807983 SB - IM MH - Humans MH - Adolescent MH - Male MH - *Motivation MH - Female MH - Finland MH - *Exercise/psychology MH - Reproducibility of Results MH - *Leisure Activities/psychology MH - Surveys and Questionnaires/standards MH - Psychometrics MH - Factor Analysis, Statistical OTO - NOTNLM OT - Assessment OT - exercise OT - factor analysis OT - motivation EDAT- 2025/03/09 15:11 MHDA- 2026/04/24 06:33 CRDT- 2025/03/08 03:23 PHST- 2026/04/24 06:33 [medline] PHST- 2025/03/09 15:11 [pubmed] PHST- 2025/03/08 03:23 [entrez] AID - 10.1080/08870446.2025.2476625 [doi] PST - ppublish SO - Psychol Health. 2026 May;41(5):759-782. doi: 10.1080/08870446.2025.2476625. Epub 2025 Mar 8. PMID- 40055312 OWN - NLM STAT- MEDLINE DCOM- 20250511 LR - 20250511 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Mar 7 TI - Exploring the prevalence and risks of eating disorders in Lebanon's athletic community. PG - 8054 LID - 10.1038/s41598-025-85613-y [doi] LID - 8054 AB - The intersection of eating disorders and competitive sports presents a critical issue that demands attention. Athletes, driven by the desire for peak performance and often subjected to intense physical and psychological pressures, are particularly vulnerable to developing eating disorders. The aim of our study is to conduct a preliminary assessment of the prevalence and risk levels of EDs among athletes in Lebanon. Using the validated EAT-26 and the DESA-6 questionnaires, 250 athletes were interviewed as part of a cross-sectional survey. Anthropometric measurements and sociodemographic characteristics were also assessed. The main findings show that the overall risk of EDs among Lebanese athletes is 21%, with 54.5% of those at-risk being males. In addition, the uncontrollable use of dietary supplements was observed in 41% of athletes. Being an adult aging 25 years and above, male, practicing sports for more than 5 years coupled with more than 15 h per week with post graduate diploma increases significantly ED risks. The prevalence of EDs among athletes in Lebanon is a well-recognized concern, highlighting the need for proactive measures and targeted interventions. CI - (c) 2025. The Author(s). FAU - Sadek, Zahra AU - Sadek Z AD - Physiotherapy department, Faculty of Public Health, Islamic University of Lebanon, Khaldeh, Lebanon. AD - Physiotherapy department, Faculty of Public Health, Lebanese University, Beirut, Lebanon. AD - PHENOL Research Group (Public HEalth Nutrition prOgram-Lebanon), Faculty of Public Health, Lebanese University, Beirut, 6573, Lebanon. FAU - Albar, Salwa AU - Albar S AD - School of Food Science and Nutrition, King Abdulaziz University, PO Box 42807, 21551, 21589, Jeddah, Saudi Arabia. FAU - Mattar, Lama AU - Mattar L AD - Nutrition Program, Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P.O. Box 13-5053, 1102, 1102 2801, Beirut, Lebanon. FAU - Jendieh, Intissar AU - Jendieh I AD - PHENOL Research Group (Public HEalth Nutrition prOgram-Lebanon), Faculty of Public Health, Lebanese University, Beirut, 6573, Lebanon. FAU - Mansour, Dina AU - Mansour D AD - Faculty of Agriculture and food sciences, American University of Beirut, Beirut, Lebanon. FAU - Zayour, Nadeen AU - Zayour N AD - PHENOL Research Group (Public HEalth Nutrition prOgram-Lebanon), Faculty of Public Health, Lebanese University, Beirut, 6573, Lebanon. AD - Faculty of Agriculture and food sciences, American University of Beirut, Beirut, Lebanon. AD - Organized Research Unit (ORU), Al Zahraa Hospital University Medical Center, Beirut, Lebanon. FAU - Hoteit, Maha AU - Hoteit M AD - PHENOL Research Group (Public HEalth Nutrition prOgram-Lebanon), Faculty of Public Health, Lebanese University, Beirut, 6573, Lebanon. maha.hoteit@cnrs.edu.lb. AD - Food Sciences Unit, National Council for Scientific Research of Lebanon (CNRS-L), Beirut, Lebanon. maha.hoteit@cnrs.edu.lb. LA - eng PT - Journal Article DEP - 20250307 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Lebanon/epidemiology MH - Male MH - Adult MH - Female MH - *Feeding and Eating Disorders/epidemiology MH - Prevalence MH - *Athletes/psychology MH - Cross-Sectional Studies MH - Young Adult MH - Risk Factors MH - Surveys and Questionnaires MH - Middle Aged MH - Adolescent MH - Sports PMC - PMC11889256 OTO - NOTNLM OT - Athletes OT - DESA-6 OT - Disordered eating patterns OT - EAT-26 OT - Eating disorders OT - Lebanon COIS- Declarations. Competing interests: The authors declare no competing interests. Funding Declaration: This research received no external funds. Human ethics and consent to participate declarations: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards." Consent to participate statement: Informed consent was obtained from all individual participants included in the study. EDAT- 2025/03/09 15:06 MHDA- 2025/03/09 15:07 PMCR- 2025/03/07 CRDT- 2025/03/07 23:23 PHST- 2024/11/18 00:00 [received] PHST- 2025/01/03 00:00 [accepted] PHST- 2025/03/09 15:07 [medline] PHST- 2025/03/09 15:06 [pubmed] PHST- 2025/03/07 23:23 [entrez] PHST- 2025/03/07 00:00 [pmc-release] AID - 10.1038/s41598-025-85613-y [pii] AID - 85613 [pii] AID - 10.1038/s41598-025-85613-y [doi] PST - epublish SO - Sci Rep. 2025 Mar 7;15(1):8054. doi: 10.1038/s41598-025-85613-y. PMID- 40054735 OWN - NLM STAT- MEDLINE DCOM- 20251121 LR - 20260306 IS - 2212-2672 (Print) IS - 2212-2672 (Linking) VI - 125 IP - 12 DP - 2025 Dec TI - Parental Overvaluation of Child Weight/Shape Is Associated With Disordered Eating in Children Beyond Associations With Parental Internalized Weight Bias. PG - 1877-1883 LID - S2212-2672(25)00076-0 [pii] LID - 10.1016/j.jand.2025.02.015 [doi] AB - BACKGROUND: Parental overvaluation (ie, parental identity based on their child's weight) and parental weight bias internalization (ie, parents' internalization of societal bias toward people living in larger bodies) are both associated with their children's disordered eating. Less is known about the extent to which these constructs overlap and how their combination may relate to pediatric disordered eating. OBJECTIVE: This study examined the relationship between parental overvaluation, parental internalized weight bias, and children's disordered eating to test whether parental overvaluation was associated with disordered eating in children beyond the effects of parental internalized weight bias. DESIGN: Cross-sectional data were collected from parents in the United States recruited online through Mechanical Turk from March 2021 through January 2022. PARTICIPANTS/SETTING: Participants included 196 parents (mean age = 38.2 years). Participants were excluded if they were younger than 21 years, lived with their child less than one-half the time, or failed to meet attention and validity checks embedded throughout assessments. MAIN OUTCOME MEASURES: Disordered eating in children behaviors (eg, overeating, binge eating, purging, and secretive eating) were evaluated. STATISTICAL ANALYSES PERFORMED: Correlations compared parental overvaluation and internalized weight bias. Hierarchical logistical regressions tested the association of internalized weight bias with disordered eating in children behaviors and then whether parental overvaluation significantly contributed to the variance in disordered eating in children eating behaviors beyond the effect of internalized weight bias. RESULTS: Across all disordered eating in children behaviors, parental internalized weight bias was significant in the first step of the logistic regression when it was the sole variable (all, P < .005). When both variables were included in models, parental overvaluation, but not weight bias, was significantly associated with all disordered eating in children behaviors (all, P < .001). CONCLUSIONS: The extent to which a parent evaluates their worth as a parent based on their child's weight/shape is more strongly associated with disordered eating behaviors in children than with internalized weight bias. More research is needed to determine whether parent-focused treatment for pediatric eating disorders could benefit from strategies aimed at shifting the valued aspects of parental identity away from child weight/shape. CI - Copyright (c) 2025 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved. FAU - Sanzari, Christina M AU - Sanzari CM AD - Department of Psychology, University at Albany, Albany, New York; Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut. FAU - Lydecker, Janet A AU - Lydecker JA AD - Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut. Electronic address: janet.lydecker@yale.edu. LA - eng GR - K23 DK115893/DK/NIDDK NIH HHS/United States GR - UL1 TR001863/TR/NCATS NIH HHS/United States PT - Journal Article DEP - 20250305 PL - United States TA - J Acad Nutr Diet JT - Journal of the Academy of Nutrition and Dietetics JID - 101573920 SB - IM MH - Humans MH - Female MH - Male MH - Cross-Sectional Studies MH - *Parents/psychology MH - Child MH - Adult MH - *Feeding and Eating Disorders/psychology MH - *Body Weight MH - *Body Image/psychology MH - United States MH - Adolescent MH - *Parent-Child Relations MH - *Weight Prejudice/psychology MH - Feeding Behavior/psychology PMC - PMC12353457 MID - NIHMS2063581 OTO - NOTNLM OT - Parental overvaluation OT - Pediatric eating disorders OT - Weight bias internalization COIS- The authors have no conflicts of interest relevant to this article to disclose. Dr. Lydecker reports other financial interests not related to the content of this paper, including grant funding from the National Eating Disorders Association and honoraria for consultation with Novo Nordisk and PRIME continuing medical education activities, review panels, and lectures. EDAT- 2025/03/09 15:10 MHDA- 2025/11/22 00:27 PMCR- 2026/03/05 CRDT- 2025/03/07 19:17 PHST- 2024/05/30 00:00 [received] PHST- 2024/12/18 00:00 [revised] PHST- 2025/02/28 00:00 [accepted] PHST- 2025/11/22 00:27 [medline] PHST- 2025/03/09 15:10 [pubmed] PHST- 2025/03/07 19:17 [entrez] PHST- 2026/03/05 00:00 [pmc-release] AID - S2212-2672(25)00076-0 [pii] AID - 10.1016/j.jand.2025.02.015 [doi] PST - ppublish SO - J Acad Nutr Diet. 2025 Dec;125(12):1877-1883. doi: 10.1016/j.jand.2025.02.015. Epub 2025 Mar 5. PMID- 40054584 OWN - NLM STAT- MEDLINE DCOM- 20250410 LR - 20260528 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 209 DP - 2025 May 1 TI - The perceived environmental sustainability (PENSUS) scale for food and drinks: Development and validation among young consumers in Belgium. PG - 107935 LID - S0195-6663(25)00088-1 [pii] LID - 10.1016/j.appet.2025.107935 [doi] AB - The perceived sustainability of food plays a significant role in young consumers' eating behaviors. While it is highly relevant to investigate these sustainability perceptions, the available measures are limited. Previous research has mostly relied on single-item measurements that only allow a surface-level understanding of food sustainability perceptions. Therefore, this research aims to provide researchers with a scale to measure perceptions of environmental food sustainability, addressing the need for such a measurement tool. We used a mixed-methods approach to develop and validate the Perceived Environmental Sustainability (PENSUS) Scale for Food and Drinks. Items were generated and refined based on expert interviews and focus group discussions with young consumers (i.e., 12-25 years) (Phase 1). The structure of the scale was explored in two online surveys (Phase 2), and subsequently confirmed with confirmatory factor analyses in four online experiments (Phase 3). This process resulted in a 10-item version of the PENSUS scale, designed to measure perceptions of 1) production & processing, 2) packaging and 3) transport. The scale serves as a concise, reliable tool to measure young consumers' environmental sustainability perceptions. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Hallez, Lotte AU - Hallez L AD - Media, Information & Persuasion Lab, KU Leuven, Parkstraat 45 - box 3603, 3000, Leuven, Belgium. Electronic address: lotte.hallez@kuleuven.be. FAU - Vanwinkelen, Kabi AU - Vanwinkelen K AD - Media, Information & Persuasion Lab, KU Leuven, Parkstraat 45 - box 3603, 3000, Leuven, Belgium. Electronic address: kabi.vanwinkelen@kuleuven.be. FAU - Boen, Filip AU - Boen F AD - Physical Activity, Sports & Health Research Group, KU Leuven, Tervuursevest 101 - box 1500, 3001, Leuven, Belgium. Electronic address: filip.boen@kuleuven.be. FAU - Smits, Tim AU - Smits T AD - Media, Information & Persuasion Lab, KU Leuven, Parkstraat 45 - box 3603, 3000, Leuven, Belgium. Electronic address: tim.smits@kuleuven.be. LA - eng PT - Journal Article PT - Validation Study DEP - 20250305 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Belgium MH - Adolescent MH - Female MH - Male MH - Young Adult MH - *Consumer Behavior MH - Adult MH - Surveys and Questionnaires MH - Child MH - Focus Groups MH - *Beverages MH - Reproducibility of Results MH - Perception MH - *Conservation of Natural Resources MH - Environment OTO - NOTNLM OT - Environmental sustainability OT - Food sustainability OT - Perceptions OT - Scale development COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/03/09 15:08 MHDA- 2025/04/11 00:32 CRDT- 2025/03/07 19:14 PHST- 2024/09/12 00:00 [received] PHST- 2025/02/21 00:00 [revised] PHST- 2025/02/26 00:00 [accepted] PHST- 2025/04/11 00:32 [medline] PHST- 2025/03/09 15:08 [pubmed] PHST- 2025/03/07 19:14 [entrez] AID - S0195-6663(25)00088-1 [pii] AID - 10.1016/j.appet.2025.107935 [doi] PST - ppublish SO - Appetite. 2025 May 1;209:107935. doi: 10.1016/j.appet.2025.107935. Epub 2025 Mar 5. PMID- 40053037 OWN - NLM STAT- MEDLINE DCOM- 20250307 LR - 20250511 IS - 1414-431X (Electronic) IS - 0100-879X (Print) IS - 0100-879X (Linking) VI - 58 DP - 2025 TI - Quantifying lactulose and mannitol using LC-MS/MS in a clinical study of children with environmental enteric disease. PG - e14156 LID - S0100-879X2025000100624 [pii] LID - 10.1590/1414-431X2024e14156 [doi] LID - e14156 AB - Dysfunction of the intestinal epithelium barrier (DIEB) is frequent and can lead to serious complications in early childhood when diagnosis and clinical intervention are limited, especially in children with environmental enteric disease and malnutrition. The use of refined analytical techniques is increasingly necessary in this context. This study aimed to validate the high-performance liquid chromatography method coupled with tandem mass spectrometry (LC-MS/MS) to measure DIEB by lactulose:mannitol ratio detection (LM test) in samples of children with different social profiles from Fortaleza, Ceara. The first experimental set was conducted to validate the method through laboratory parameters, such as limit of detection (LD), limit of quantification (LQ), specificity/selectivity, linearity, accuracy, and precision. All validation parameters achieved detection and recovery standards within an acceptable coefficient of variation. Community samples (human development index (HDI) from 0.000 to 0.8). Mannitol excretion was lower in the EED group than in the control group (P<0.0001). On the other hand, LM was higher in this group compared to the control group (P<0.0001). For the first time, a robust analytical approach was used to detect biomarkers of environmental enteropathy (LM) in community samples, confirming with high-sensitivity the damage to the intestinal epithelial barrier function in populations living in low socio-economic conditions. FAU - Magalhaes, L M V C AU - Magalhaes LMVC AUID- ORCID: 0000-0001-6990-4903 AD - Centro de Biomedicina, Universidade Federal do Ceara, Fortaleza, CE, Brasil. FAU - Rodrigues, F A P AU - Rodrigues FAP AUID- ORCID: 0000-0001-9890-4232 AD - Centro de Biomedicina, Universidade Federal do Ceara, Fortaleza, CE, Brasil. AD - Departamento de Educacao Fisica e Esporte, Instituto Federal de Educacao, Ciencia e Tecnologia do Ceara, Fortaleza, CE, Brasil. FAU - Filho, J Q AU - Filho JQ AUID- ORCID: 0000-0002-9619-4553 AD - Centro de Biomedicina, Universidade Federal do Ceara, Fortaleza, CE, Brasil. FAU - Gondim, R N D G AU - Gondim RNDG AUID- ORCID: 0000-0001-7082-5532 AD - Centro de Biomedicina, Universidade Federal do Ceara, Fortaleza, CE, Brasil. FAU - Ribeiro, S A AU - Ribeiro SA AUID- ORCID: 0000-0001-8335-6317 AD - Centro de Biomedicina, Universidade Federal do Ceara, Fortaleza, CE, Brasil. FAU - Rola, T B M AU - Rola TBM AUID- ORCID: 0000-0002-4806-501X AD - Faculdade de Medicina, Centro Universitario Christus, Fortaleza, CE, Brasil. FAU - Clementino, M A F AU - Clementino MAF AUID- ORCID: 0000-0002-0628-8047 AD - Centro de Biomedicina, Universidade Federal do Ceara, Fortaleza, CE, Brasil. AD - Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceara, Fortaleza, CE, Brasil. FAU - Maciel, B L L AU - Maciel BLL AUID- ORCID: 0000-0002-0724-1961 AD - Programa de Pos-Graduacao em Nutricao, Departamento de Nutricao, Universidade Federal de Rio Grande do Norte, Natal, RN, Brasil. FAU - Magalhaes, P J C AU - Magalhaes PJC AUID- ORCID: 0000-0002-9073-5750 AD - Centro de Biomedicina, Universidade Federal do Ceara, Fortaleza, CE, Brasil. AD - Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceara, Fortaleza, CE, Brasil. FAU - Havt, A AU - Havt A AUID- ORCID: 0000-0002-4546-2976 AD - Centro de Biomedicina, Universidade Federal do Ceara, Fortaleza, CE, Brasil. AD - Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceara, Fortaleza, CE, Brasil. FAU - Santos, A A AU - Santos AA AUID- ORCID: 0000-0003-0912-3720 AD - Centro de Biomedicina, Universidade Federal do Ceara, Fortaleza, CE, Brasil. AD - Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceara, Fortaleza, CE, Brasil. FAU - Lima, A A M AU - Lima AAM AUID- ORCID: 0000-0002-0299-1747 AD - Centro de Biomedicina, Universidade Federal do Ceara, Fortaleza, CE, Brasil. AD - Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceara, Fortaleza, CE, Brasil. LA - eng PT - Journal Article PT - Validation Study DEP - 20250303 PL - Brazil TA - Braz J Med Biol Res JT - Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas JID - 8112917 RN - 4618-18-2 (Lactulose) RN - 3OWL53L36A (Mannitol) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Lactulose/analysis/urine MH - *Mannitol/analysis/urine MH - Tandem Mass Spectrometry/methods MH - Female MH - Child MH - Male MH - Chromatography, High Pressure Liquid/methods MH - Case-Control Studies MH - Child, Preschool MH - Reproducibility of Results MH - Sensitivity and Specificity MH - Limit of Detection MH - Feces/chemistry MH - Biomarkers MH - Intestinal Mucosa MH - *Intestinal Diseases/diagnosis MH - Liquid Chromatography-Mass Spectrometry PMC - PMC11884778 EDAT- 2025/03/07 12:24 MHDA- 2025/03/07 12:25 PMCR- 2025/03/03 CRDT- 2025/03/07 10:54 PHST- 2024/09/09 00:00 [received] PHST- 2024/12/18 00:00 [accepted] PHST- 2025/03/07 12:25 [medline] PHST- 2025/03/07 12:24 [pubmed] PHST- 2025/03/07 10:54 [entrez] PHST- 2025/03/03 00:00 [pmc-release] AID - S0100-879X2025000100624 [pii] AID - 10.1590/1414-431X2024e14156 [doi] PST - epublish SO - Braz J Med Biol Res. 2025 Mar 3;58:e14156. doi: 10.1590/1414-431X2024e14156. eCollection 2025. PMID- 40052829 OWN - NLM STAT- MEDLINE DCOM- 20260811 LR - 20260813 IS - 1550-5049 (Electronic) IS - 0889-4655 (Print) IS - 0889-4655 (Linking) VI - 41 IP - 5 DP - 2026 Sep-Oct 01 TI - Perceived Discrimination, Trauma, Mental Health, and Blood Pressure Outcomes Among Young African American/Black Mothers in the InterGEN Study. PG - 371-377 LID - 10.1097/JCN.0000000000001190 [doi] AB - BACKGROUND: African American (AA) women are disproportionately affected by hypertension. Discrimination, which can be traumatic, and depressive symptoms are independently associated with blood pressure (BP). OBJECTIVE: We assessed whether the combined influence of discrimination and race-related trauma and depressive symptoms influenced BP over time. METHODS: We conducted a secondary data analysis of data from a longitudinal cohort study examining factors associated with BP in 250 AA/Black mother-child dyads. Eligible participants were AA/Black mothers, 21 years and older, with a biological child aged 3-5 years. Clinical (BP, body mass index) and psychosocial measures (racial discrimination, major discrimination, race-related stress, depressive symptoms) were examined. Principal component analysis and linear regression were completed to assess the associations of discrimination, race-related trauma, and depressive symptoms with maternal BP. RESULTS: Data from 183 participants were analyzed. Principal component analysis identified 2 key components: overall discrimination and race-related trauma (principal component 1) and depressive symptoms (principal component 2), which explained 83% of data variation. Linear regression analyses revealed principal component 1 was associated with changes in systolic BP ( b = 0.92; P = .04), whereas principal component 2 was not ( b = 0.31; P = .71). CONCLUSIONS: Our findings highlight the need to further explore experiences of discrimination and race-related trauma as a contributing factor for hypertension. In addition, building on existing efforts, future studies should further analyze the presentation of depressive symptoms among AA women to inform the development and validation of culturally sensitive screening tools that effectively capture these symptoms and enhance access to care. CI - Copyright (c) 2025 The Authors. Published by Wolters Kluwer Health, LLC. FAU - Nyembwe, Alexandria AU - Nyembwe A AUID- ORCID: 0000-0002-6302-0899 AD - Alexandria Nyembwe, PhD, MBA, RN, PMH-BC, Center for Research on People of Color, Columbia University School of Nursing, New York, New York. FAU - Zhao, Yihong AU - Zhao Y AD - Yihong Zhao, PhD, Center for Research on People of Color, Columbia University School of Nursing, New York, New York. FAU - Millender, Eugenia AU - Millender E AD - Eugenia Millender, PhD, RN, PMH-APRN, CDE, FAAN, College of Nursing, Florida State University, Tallahassee. FAU - Hall, Kelli AU - Hall K AD - Kelli Hall, PhD, School of Public Health & Tropical Medicine, Departments of Social, Behavioral, & Population Health Sciences, Mary Amelia Center for Women's Health Equity Research, Tulane University, New Orleans, Louisiana. FAU - Caceres, Billy A AU - Caceres BA AD - Billy A. Caceres, PhD, RN, FAHA, FAAN, Center for Research on People of Color, Columbia University School of Nursing, New York, New York. FAU - Taylor, Brittany AU - Taylor B AD - Brittany Taylor, PhD, RN, Center for Research on People of Color, Columbia University School of Nursing, New York, New York. FAU - Morrison, Morgan T AU - Morrison MT AD - Morgan T. Morrison, MA, Center for Research on People of Color, Columbia University School of Nursing, New York, New York. FAU - Prescott, Laura AU - Prescott L AD - Laura Prescott, MA, Center for Research on People of Color, Columbia University School of Nursing, New York, New York. FAU - Potts-Thompson, Stephanie AU - Potts-Thompson S AUID- ORCID: 0000-0003-3484-0852 AD - Stephanie Potts-Thompson, MPH, Center for Research on People of Color, Columbia University School of Nursing, New York, New York. FAU - Aziz, Arezo AU - Aziz A AD - Arezo Aziz, DNP, MS, APRN, FNP-BC, Center for Research on People of Color, Columbia University School of Nursing, New York, New York. FAU - Aruleba, Fisola AU - Aruleba F AD - Fisola Aruleba, BS, CUNY School of Medicine, New York, New York. FAU - Crusto, Cindy AU - Crusto C AD - Cindy Crusto, PhD, Keck School of Medicine of USC, Los Angeles, CA. FAU - Taylor, Jacquelyn Y AU - Taylor JY AD - Jacquelyn Y. Taylor, PhD, PNP-BC, RN, FAHA, FAAN, Center for Research on People of Color, Columbia University School of Nursing, New York, New York. LA - eng GR - L30 HL154217/HL/NHLBI NIH HHS/United States GR - R01 NR013520/NR/NINR NIH HHS/United States PT - Journal Article DEP - 20250307 PL - United States TA - J Cardiovasc Nurs JT - The Journal of cardiovascular nursing JID - 8703516 SB - IM MH - Adult MH - Child, Preschool MH - Female MH - Humans MH - Young Adult MH - *Black or African American/psychology MH - *Blood Pressure MH - Depression/ethnology/psychology MH - Hypertension/psychology/ethnology MH - Longitudinal Studies MH - *Mental Health/ethnology MH - *Mothers/psychology MH - *Racism/psychology MH - Secondary Data Analysis PMC - PMC13148011 MID - NIHMS2157417 OTO - NOTNLM OT - African American/black women OT - blood pressure OT - depressive symptoms OT - discrimination OT - trauma COIS- The authors have no conflicts of interest to disclose. EDAT- 2025/03/07 12:24 MHDA- 2026/08/11 18:29 PMCR- 2026/08/10 CRDT- 2025/03/07 09:13 PHST- 2026/08/11 18:29 [medline] PHST- 2025/03/07 12:24 [pubmed] PHST- 2025/03/07 09:13 [entrez] PHST- 2026/08/10 00:00 [pmc-release] AID - 00005082-990000000-00266 [pii] AID - JCN-D-24-00309 [pii] AID - 10.1097/JCN.0000000000001190 [doi] PST - ppublish SO - J Cardiovasc Nurs. 2026 Sep-Oct 01;41(5):371-377. doi: 10.1097/JCN.0000000000001190. Epub 2025 Mar 7. PMID- 40049809 OWN - NLM STAT- MEDLINE DCOM- 20250306 LR - 20250511 IS - 1875-6263 (Electronic) IS - 1028-4559 (Linking) VI - 64 IP - 2 DP - 2025 Mar TI - The new era of risk assessment for hypertension in pregnancy: From clinical to biochemical markers in a comprehensive predictive model. PG - 253-264 LID - S1028-4559(25)00022-1 [pii] LID - 10.1016/j.tjog.2024.10.014 [doi] AB - OBJECTIVE: This study aims to develop and validate a model based on the weighted random forest (WRF) algorithm to predict early-onset preeclampsia (PE) and to assess the importance of various clinical and biochemical markers in early risk identification. MATERIALS AND METHODS: This study was conducted at the Jiangxi Maternal and Child Health Hospital and involved 12,699 pregnant women from January 2019 to June 2022. Extensive clinical and biochemical markers were collected through prenatal care data, which were used to construct a predictive model for early-onset PE. The model was developed using the WRF and Logistic regression methods, and multivariable analysis was employed to identify markers significantly associated with the risk of PE. RESULTS: The relative importance of various markers was evaluated using the random forest (RF) model in a sample of 1200 patients diagnosed with PE. Blood pressure and pre-pregnancy body mass index (BMI) were identified as the most critical variables affecting the accuracy of the PE prediction model. The WRF model demonstrated higher predictive accuracy (AUC = 0.9614) than the Logistic regression model (AUC = 0.9138), highlighting its superiority in early risk identification for PE. CONCLUSION: The WRF-based predictive model developed in this study effectively predicts the risk of early-onset PE, with blood pressure and BMI as vital predictive factors. These findings underscore the importance of employing a comprehensive predictive model for risk assessment in early pregnancy, facilitating early intervention and improving health outcomes for pregnant women and their newborns. CI - Copyright (c) 2025. Published by Elsevier B.V. FAU - Nie, Liju AU - Nie L AD - Department of Obstetrics, Jiangxi Maternal and Child Health Hospital, Nanchang, China; Department of Obstetrics, Maternal and Child Health Hospital of Nanchang Medical College, Nanchang, China. FAU - Zhang, Ziyu AU - Zhang Z AD - Department of Pathology, Jiangxi Maternal and Child Health Hospital, Nanchang, China. FAU - Yao, Qinglan AU - Yao Q AD - Department of Obstetrics, Jiangxi Maternal and Child Health Hospital, Nanchang, China; Department of Obstetrics, Maternal and Child Health Hospital of Nanchang Medical College, Nanchang, China. FAU - Chen, Huayan AU - Chen H AD - Department of Obstetrics, Jiangxi Maternal and Child Health Hospital, Nanchang, China; Department of Obstetrics, Maternal and Child Health Hospital of Nanchang Medical College, Nanchang, China. FAU - Xu, Chao AU - Xu C AD - Fujian Normal University, Fuzhou 350007, China. FAU - Chen, Lin AU - Chen L AD - Fujian Normal University, Fuzhou 350007, China. FAU - Liu, Chengcheng AU - Liu C AD - Department of Obstetrics, Jiangxi Maternal and Child Health Hospital, Nanchang, China; Department of Obstetrics, Maternal and Child Health Hospital of Nanchang Medical College, Nanchang, China. FAU - Tu, Lantao AU - Tu L AD - Department of Obstetrics, Jiangxi Maternal and Child Health Hospital, Nanchang, China; Department of Obstetrics, Maternal and Child Health Hospital of Nanchang Medical College, Nanchang, China. FAU - Yi, Yuping AU - Yi Y AD - Department of Obstetrics, Jiangxi Maternal and Child Health Hospital, Nanchang, China; Department of Obstetrics, Maternal and Child Health Hospital of Nanchang Medical College, Nanchang, China. FAU - Huang, Tianqiang AU - Huang T AD - Fujian Normal University, Fuzhou 350007, China. FAU - Zeng, Xiaoming AU - Zeng X AD - Department of Obstetrics, Jiangxi Maternal and Child Health Hospital, Nanchang, China; Department of Obstetrics, Maternal and Child Health Hospital of Nanchang Medical College, Nanchang, China. Electronic address: zxmqzh28@163.com. FAU - Yu, Lamei AU - Yu L AD - Department of Obstetrics, Jiangxi Maternal and Child Health Hospital, Nanchang, China; Department of Obstetrics, Maternal and Child Health Hospital of Nanchang Medical College, Nanchang, China. Electronic address: dryulamei@126.com. LA - eng PT - Journal Article PL - China (Republic : 1949- ) TA - Taiwan J Obstet Gynecol JT - Taiwanese journal of obstetrics & gynecology JID - 101213819 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Pregnancy MH - Risk Assessment/methods MH - Adult MH - Biomarkers/blood MH - *Pre-Eclampsia/diagnosis/blood MH - Body Mass Index MH - Logistic Models MH - Predictive Value of Tests MH - Blood Pressure MH - Algorithms MH - Risk Factors OTO - NOTNLM OT - Biochemical markers OT - Clinical markers OT - Predictive model OT - Preeclampsia OT - Weighted random forest COIS- Conflict of interest The author declares no conflict of interest. EDAT- 2025/03/07 00:21 MHDA- 2025/03/07 00:22 CRDT- 2025/03/06 20:59 PHST- 2024/10/09 00:00 [accepted] PHST- 2025/03/07 00:22 [medline] PHST- 2025/03/07 00:21 [pubmed] PHST- 2025/03/06 20:59 [entrez] AID - S1028-4559(25)00022-1 [pii] AID - 10.1016/j.tjog.2024.10.014 [doi] PST - ppublish SO - Taiwan J Obstet Gynecol. 2025 Mar;64(2):253-264. doi: 10.1016/j.tjog.2024.10.014. PMID- 40048153 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250315 IS - 2561-6722 (Electronic) IS - 2561-6722 (Linking) VI - 8 DP - 2025 Mar 6 TI - Novel Profiles of Family Media Use: Latent Profile Analysis. PG - e59215 LID - 10.2196/59215 [doi] LID - e59215 AB - BACKGROUND: Over the past 3 decades, digital and screen media have evolved from broadcast, stationary platforms to a complex environment of interactive, omnipresent, mobile media. Thus, clinical guidance centered around unidimensional concepts such as "screen time" must be modernized to help families navigate the intricate digital ecosystems of readily available entertainment and information. OBJECTIVE: This study aimed to identify and examine distinct latent profiles of media use in families with young children. We hypothesized that latent profile analysis (LPA) would identify different media use profiles characterized by more heavy, reactive, individual, and permissive media use and more intentional, regulated, or shared uses of media. METHODS: We analyzed data from 398 preschool-aged children. English-speaking parents were recruited through community settings. Participants completed surveys regarding several aspects of family media use, such as child device use or activities, parent concerns and attitudes, limit setting and mediation, parent media use, and technology interference, examined in an LPA. The number of latent media profiles was determined using Bayesian Information Criteria. Parents also completed validated scales of parenting stress, depression symptoms, parenting style, child behavior, child sleep, and household disorganization. Multivariable logistic regression was used to examine parent, child, and household predictors of group membership. RESULTS: The LPA yielded 2 distinct groups that differed in the duration of media used by parents and children, to calm children or help them fall asleep. Statistically significant differences between groups included: families in group 1 (n=236, which we termed social-emotional drivers) had parents who preferred interactions via text or email to in-person (P=.01) and were more likely to use media to calm their children (P=.03); in contrast, families in group 2 (n=162, intentional media) used more task-oriented media, like audio and nongame apps (P=.01), had more concerns about effects of media on child language development (P=.04), and used more media restrictions (P=.01). In regression models, female sex of the parent respondent, greater number of siblings, and later child sleep midpoint independently predicted group 1 membership. CONCLUSIONS: Findings suggest divergent family media use patterns that can be categorized into 2 main media user groups: those using media to buffer social situations or regulate emotions and those planning mobile device use around functional purposes and concerns around media exposure. Profiles were associated with household size and child sleep. More research is needed to examine the impact of social and emotional uses of media on child outcomes. CI - (c) Nicole Hamp, Jenny Radesky, Heidi M Weeks, Alison L Miller, Niko Kaciroti. Originally published in JMIR Pediatrics and Parenting (https://pediatrics.jmir.org). FAU - Hamp, Nicole AU - Hamp N AUID- ORCID: 0000-0001-7124-3040 AD - Division of Developmental Behavioral Pediatrics, University of Michigan Medical School, D2204 CS Mott Children's Hospital, 1500 E. Medical Ctr Dr, Ann Arbor, MI, 48109-5718, United States, 1 2485615770. FAU - Radesky, Jenny AU - Radesky J AUID- ORCID: 0000-0002-7721-7350 AD - Division of Developmental Behavioral Pediatrics, University of Michigan Medical School, D2204 CS Mott Children's Hospital, 1500 E. Medical Ctr Dr, Ann Arbor, MI, 48109-5718, United States, 1 2485615770. FAU - Weeks, Heidi M AU - Weeks HM AUID- ORCID: 0000-0003-3467-7987 AD - University of Michigan School of Public Health, Ann Arbor, MI, United States. FAU - Miller, Alison L AU - Miller AL AUID- ORCID: 0000-0002-9866-0204 AD - University of Michigan School of Public Health, Ann Arbor, MI, United States. FAU - Kaciroti, Niko AU - Kaciroti N AUID- ORCID: 0000-0001-8843-8231 AD - University of Michigan School of Public Health, Ann Arbor, MI, United States. LA - eng GR - R21 HD094051/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20250306 PL - Canada TA - JMIR Pediatr Parent JT - JMIR pediatrics and parenting JID - 101727244 PMC - PMC11905923 OTO - NOTNLM OT - LPA OT - child OT - computer use OT - digital media OT - latent profile analysis OT - media use OT - mobile media OT - pediatrics OT - preschool OT - questionnaire OT - survey OT - technology use COIS- Conflicts of Interest: NH has ownership interest in Arbor Autism Centers LLC. In the past year, JR received fees from Melissa & Doug LLC and research funding from Common Sense Media. HMW reported receiving grants from the National Institute of Child Health and Human Development outside the submitted work. ALM reported receiving grants from the National Institutes of Health outside the submitted work. NK reported receiving grants from the National Institutes of Health outside the submitted work. EDAT- 2025/03/06 12:33 MHDA- 2025/03/06 12:34 PMCR- 2025/03/06 CRDT- 2025/03/06 11:25 PHST- 2024/06/13 00:00 [received] PHST- 2024/11/19 00:00 [revised] PHST- 2024/11/28 00:00 [accepted] PHST- 2025/03/06 12:34 [medline] PHST- 2025/03/06 12:33 [pubmed] PHST- 2025/03/06 11:25 [entrez] PHST- 2025/03/06 00:00 [pmc-release] AID - v8i1e59215 [pii] AID - 59215 [pii] AID - 10.2196/59215 [doi] PST - epublish SO - JMIR Pediatr Parent. 2025 Mar 6;8:e59215. doi: 10.2196/59215. PMID- 40046113 OWN - NLM STAT- MEDLINE DCOM- 20250511 LR - 20250605 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Association of mental health status with perceived barriers to healthy diet among Bangladeshi adults: a quantile regression-based approach. PG - 1487107 LID - 10.3389/fpubh.2025.1487107 [doi] LID - 1487107 AB - INTRODUCTION: Maintaining a healthy diet is essential for both physical and mental well-being. This study investigated the association of mental health status with perceived barriers to maintaining healthy diets among Bangladeshi adults. METHOD: This cross-sectional study was conducted between January to June 2023 in Bangladesh. A total of 400 adults aged between 18 and 60 years who reside in Dhaka, Chattogram, and Gazipur cities were recruited using a multistage sampling technique. A questionnaire consisting of 12 questions adapted from previous literature was used to assess barriers to healthy diets. Mental health status was measured using the validated DASS-21 scale. A quantile regression-based approach was used to ascertain the association between mental health status and barriers to healthy diets. RESULTS: The five most frequently reported barriers to a healthy diet were the use of junk food as a reward or treat (56.25%), difficulty in controlling eating habits when with friends (56%), the cost of healthy food (44.5%), difficulty in taking healthy food at work (46.5%), and difficult to stay motivated to eat healthy food (25%). The study found that gender, marital status, living arrangement, working hours, and family monthly income were significantly associated with perceived barriers to healthy diets. Mental health status was observed to be associated with barriers to healthy diet scores. Depression (beta =0.34, 95% CI: 0.17 to 0.51) and anxiety (beta =0.14, 95% CI: 0.01 to 0.28) were significantly associated with perceived barrier scores at the 50th quantile. Stress was also significantly associated with perceived barrier scores at the 10th (beta =0.18, 95% CI: 0.09 to 0.27) and the 25th quantiles (beta =0.12, 95% CI: 0.03 to 0.21). CONCLUSION: In light of the findings, it is imperative to prioritize the advocacy of policies that integrate mental health services and stress management strategies into public health initiatives. CI - Copyright (c) 2025 Hasan, Kundu, Jahan, Basak, Hasan and Sharif. FAU - Hasan, A B M Nahid AU - Hasan ABMN AD - Department of Public Health, North South University, Dhaka, Bangladesh. AD - Department of Public Health Nutrition, Primeasia University, Dhaka, Bangladesh. FAU - Kundu, Satyajit AU - Kundu S AD - Public Health, School of Medicine and Dentistry, Griffith University, Gold Coast Campus, Southport, QLD, Australia. FAU - Jahan, Ishrat AU - Jahan I AD - School of Public Health, University of Queensland, Herston, QLD, Australia. FAU - Basak, Tapu AU - Basak T AD - Department of Public Health Nutrition, Primeasia University, Dhaka, Bangladesh. FAU - Hasan, Mahamudul AU - Hasan M AD - World Health Organization (Bangladesh), Dhaka, Bangladesh. FAU - Sharif, Azaz Bin AU - Sharif AB AD - Department of Public Health, North South University, Dhaka, Bangladesh. LA - eng GR - 001/WHO_/World Health Organization/International PT - Journal Article DEP - 20250219 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Bangladesh MH - Adult MH - Female MH - Male MH - Cross-Sectional Studies MH - *Mental Health/statistics & numerical data MH - Middle Aged MH - Surveys and Questionnaires MH - *Diet, Healthy/psychology/statistics & numerical data MH - Adolescent MH - Young Adult MH - Feeding Behavior/psychology PMC - PMC11879812 OTO - NOTNLM OT - Bangladesh OT - healthy diet OT - mental health OT - perceived barriers OT - quantile regression COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/03/06 11:27 MHDA- 2025/03/06 11:28 PMCR- 2025/02/19 CRDT- 2025/03/06 04:36 PHST- 2024/08/27 00:00 [received] PHST- 2025/02/05 00:00 [accepted] PHST- 2025/03/06 11:28 [medline] PHST- 2025/03/06 11:27 [pubmed] PHST- 2025/03/06 04:36 [entrez] PHST- 2025/02/19 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1487107 [doi] PST - epublish SO - Front Public Health. 2025 Feb 19;13:1487107. doi: 10.3389/fpubh.2025.1487107. eCollection 2025. PMID- 40046065 OWN - NLM STAT- MEDLINE DCOM- 20250511 LR - 20250928 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 16 DP - 2025 TI - Association between systemic immune-inflammation index and central obesity in pediatric populations: a cross-sectional and cohort study. PG - 1546612 LID - 10.3389/fimmu.2025.1546612 [doi] LID - 1546612 AB - BACKGROUND: Central obesity in children represents a significant public health concern due to its strong association with an elevated risk of metabolic and cardiovascular disorders. The systemic immune inflammation index (SII) has been implicated in the pathophysiology of obesity-related chronic inflammation. Despite its potential relevance, the specific relationship between central obesity and SII in the pediatric population remains insufficiently explored. The objective of this study was to examine the relationship between SII and central obesity, with a particular focus on the potential of SII as a predictor of central obesity and a means of preventing obesity at an early stage of life. METHODS: Waist-to-height ratio (WHtR), subcutaneous fat, and visceral fat were employed as obesity proxies. Central obesity was defined according to WHtR with a cutoff value of 0.46. The implications of SII on central obesity were examined in a sample of 4,730 individuals in 2021 and validated through a prospective study involving 1,425 subjects in 2023. Cross-sectional associations between SII and central obesity were examined using binomial logistic regression models and generalized linear models. The restricted cubic spline regression was used to explore the non-linear relationship between SII and obesity indicators. In a prospective study, we employed a modified Poisson regression model to investigate the potential causal relationship between SII and central obesity. RESULTS: Cross-sectionally, adolescents in the highest quartile of SII levels exhibited the greatest risk for central obesity(OR=3.07, 95% CI:2.45~3.87) when compared to those in the lowest quartile. Subgroup analyses showed that higher SII was associated with central obesity. Longitudinally, individuals in the highest SII quartile were found to have the highest risk of developing central obesity (RR=1.83, 95% CI:1.18~2.83) over time. CI - Copyright (c) 2025 Zhang, Kong, Zhou, Liu, Wen, Lin, Xuan, Lu, Su, Li, Tang, Xiong, Yao and Li. FAU - Zhang, Qian AU - Zhang Q AD - Department of Child and Adolescent Chronic Disease Prevention and Control, Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong, China. AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Kong, Bingxuan AU - Kong B AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Zhou, Zhiyu AU - Zhou Z AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Liu, Fangqu AU - Liu F AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Wen, Erya AU - Wen E AD - Department of Child and Adolescent Chronic Disease Prevention and Control, Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong, China. FAU - Lin, Bingliang AU - Lin B AD - Department of Child and Adolescent Chronic Disease Prevention and Control, Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong, China. FAU - Xuan, Peng AU - Xuan P AD - Department of Child and Adolescent Chronic Disease Prevention and Control, Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong, China. FAU - Lu, Wenlong AU - Lu W AD - Department of Child and Adolescent Chronic Disease Prevention and Control, Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong, China. FAU - Su, Zhe AU - Su Z AD - Department of Endocrinology, Shenzhen Children's Hospital, Shenzhen, China. FAU - Li, Yanyan AU - Li Y AD - Department of Child and Adolescent Chronic Disease Prevention and Control, Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong, China. FAU - Tang, Yuhan AU - Tang Y AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Xiong, Jingfan AU - Xiong J AD - Department of Child and Adolescent Chronic Disease Prevention and Control, Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong, China. FAU - Yao, Ping AU - Yao P AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Li, Yan AU - Li Y AD - Department of Child and Adolescent Chronic Disease Prevention and Control, Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong, China. LA - eng PT - Journal Article DEP - 20250219 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 SB - IM MH - Humans MH - Female MH - Child MH - Male MH - *Obesity, Abdominal/immunology/epidemiology/diagnosis MH - Cross-Sectional Studies MH - Adolescent MH - *Pediatric Obesity/immunology/epidemiology/diagnosis MH - *Inflammation/immunology MH - Prospective Studies MH - Cohort Studies MH - Waist-Height Ratio MH - Risk Factors PMC - PMC11880016 OTO - NOTNLM OT - central obesity OT - children and adolescents OT - cohort study OT - immune-inflammation index (SII) OT - inflammation COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/03/06 06:22 MHDA- 2025/03/06 06:23 PMCR- 2025/01/01 CRDT- 2025/03/06 04:35 PHST- 2024/12/17 00:00 [received] PHST- 2025/02/03 00:00 [accepted] PHST- 2025/03/06 06:23 [medline] PHST- 2025/03/06 06:22 [pubmed] PHST- 2025/03/06 04:35 [entrez] PHST- 2025/01/01 00:00 [pmc-release] AID - 10.3389/fimmu.2025.1546612 [doi] PST - epublish SO - Front Immunol. 2025 Feb 19;16:1546612. doi: 10.3389/fimmu.2025.1546612. eCollection 2025. PMID- 40045483 OWN - NLM STAT- MEDLINE DCOM- 20250306 LR - 20250511 IS - 1365-2214 (Electronic) IS - 0305-1862 (Linking) VI - 51 IP - 2 DP - 2025 Mar TI - The 24-Hour Activity Checklist for Cerebral Palsy: Translation, Content Validity and Test-Retest Reliability of Portuguese Versions. PG - e70057 LID - 10.1111/cch.70057 [doi] AB - BACKGROUND: The importance of 24-h movement behaviour, including sleep, physical activity (PA) and sedentary behaviour (SB), has gained prominence due to its significant impact on the health and development of children, including those with cerebral palsy (CP). The 24-h activity checklist for CP, a tool developed in the Netherlands to monitor the activity in CP paediatric population, requires translation and cultural adaptation to Portuguese for use in Brazil and Portugal. METHODS: This cross-sectional methodological study involved translating and culturally adapting the 24-h activity checklist for CP into Brazilian Portuguese (BP) and European Portuguese (EP) languages. The process included forward translation, synthesis and backward translation, expert panel evaluation and pretesting. Brazilian and Portuguese experts appraised content validity, assessed by the individual item (I-CVI) and scale level content validity index scores (S-CVI/Ave). Sixty parents of children with CP participated in the test-retest analysis, reported with the Intraclass Correlation Coefficients (ICCs). RESULTS: I-CVI scores were higher than 0.78 for both versions. S-CVI/Ave scores were considered excellent for BP (0.91) and EP version (1.0). Expert's appraisal results in the inclusion of a question about sleep-related time indicators and the split of sleep, PA, and screen time questions for weekdays and weekends. Brazilian and Portuguese parents of children with CP reported understanding on instructions, questions, and answer options. The ICC values range from 0.81 to 0.99 and 0.6 to 0.98, for BP and EP, respectively. CONCLUSIONS: The BP and EP versions of 24-h activity checklist for CP demonstrated good content validity and test-retest reliability, supporting its use in Brazil and Portugal. This tool can contribute to improving communication between families and healthcare professionals to monitor and develop tailored interventions for healthy movement behaviours in children with CP. CI - (c) 2025 John Wiley & Sons Ltd. FAU - Vila-Nova, Fabio AU - Vila-Nova F AUID- ORCID: 0000-0002-6647-452X AD - Laboratory of Motor Behavior, Faculty of Human Kinetics, University of Lisbon, Lisbon, Portugal. FAU - Sa, Cristina Dos Santos Cardoso de AU - Sa CDSC AUID- ORCID: 0000-0002-0920-6668 AD - Departamento de Fisioterapia, Escola Superior de Saude do Alcoitao, Lisbon, Portugal. FAU - Leite, Hercules Ribeiro AU - Leite HR AUID- ORCID: 0000-0001-8977-8131 AD - Graduate Program in Rehabilitation Sciences, School of Physical Education, Physical Therapy, and Occupational Therapy, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. FAU - Cadete, Ana AU - Cadete A AUID- ORCID: 0000-0002-3853-3895 AD - Centro de Reabilitacao de Paralisia Cerebral Calouste Gulbenkian, Santa Casa da Misericordia de Lisboa, Lisbon, Portugal. FAU - Folha, Teresa AU - Folha T AUID- ORCID: 0000-0002-0437-2675 AD - Departamento de Epidemiologia, Instituto Nacional de Saude Doutor Ricardo Jorge, Lisbon, Portugal. FAU - Longo, Egmar AU - Longo E AUID- ORCID: 0000-0001-6263-1818 AD - Department of Physiotherapy, Federal University of Paraiba, Joao Pessoa, Paraiba, Brazil. FAU - Martins, Maria Elisabete AU - Martins ME AUID- ORCID: 0000-0002-3101-2456 AD - Escola Superior de Saude do Alcoitao, Lisbon, Portugal. FAU - Oliveira, Raul AU - Oliveira R AUID- ORCID: 0000-0001-9750-0527 AD - CIPER, Neuromuscular Research Lab, Faculty of Human Kinetics, University of Lisbon, Lisbon, Portugal. LA - eng PT - Journal Article PT - Validation Study PL - England TA - Child Care Health Dev JT - Child: care, health and development JID - 7602632 SB - IM EIN - Child Care Health Dev. 2025 May;51(3):e70073. doi: 10.1111/cch.70073. PMID: 40195041 MH - Humans MH - *Cerebral Palsy/physiopathology/psychology MH - Cross-Sectional Studies MH - *Checklist MH - Portugal MH - Reproducibility of Results MH - Male MH - Brazil MH - Female MH - Child MH - *Exercise MH - Translations MH - Sedentary Behavior MH - Child, Preschool MH - Sleep MH - Cross-Cultural Comparison OTO - NOTNLM OT - Brazilian Portuguese OT - European Portuguese OT - cerebral palsy OT - movement behaviour assessment OT - physical activity OT - screen time OT - sleep EDAT- 2025/03/06 06:21 MHDA- 2025/03/06 06:22 CRDT- 2025/03/06 00:33 PHST- 2025/02/12 00:00 [revised] PHST- 2024/06/11 00:00 [received] PHST- 2025/02/17 00:00 [accepted] PHST- 2025/03/06 06:22 [medline] PHST- 2025/03/06 06:21 [pubmed] PHST- 2025/03/06 00:33 [entrez] AID - 10.1111/cch.70057 [doi] PST - ppublish SO - Child Care Health Dev. 2025 Mar;51(2):e70057. doi: 10.1111/cch.70057. PMID- 40045346 OWN - NLM STAT- MEDLINE DCOM- 20250511 LR - 20250529 IS - 1880-6805 (Electronic) IS - 1880-6791 (Print) IS - 1880-6791 (Linking) VI - 44 IP - 1 DP - 2025 Mar 5 TI - Relationship between age and various muscle quality indices in Japanese individuals via bioelectrical impedance analysis (BIA). PG - 8 LID - 10.1186/s40101-025-00388-5 [doi] LID - 8 AB - BACKGROUND: Bioelectrical impedance analysis (BIA) is widely used as a convenient method of measuring body composition. The validity of the phase angle (PhA), impedance rate (IR), and resistance rate (RR) as indices of muscle quality using BIA has been suggested. This study aimed to investigate the relationship between these muscle quality indices and age, and to clarify their characteristics. METHODS: The appendicular muscle mass (AMM), AMM corrected for body mass index (AMM/BMI), PhA, IR, and RR were determined using BIA in 1376 Japanese individuals (532 males and 844 females) aged 15-95 years. The PhA was determined from a 50-kHz current, and the IR and RR were determined from the impedance and resistance ratios between the 250- and 5-kHz currents. RESULTS: AMM/BMI showed greater age-related changes than the other indices of muscle mass. Significant differences in PhA, IR, and RR were found for the whole body at age >/= 50 years and for the lower limbs at age >/= 30 years, compared to those in their 20 s. For the arms, age-related changes were small, and significant differences in PhA of females were only observed at aged >/= 85 years, whereas significant differences in IR and RR were observed at aged >/= 75 years, compared to those in their 20s. CONCLUSION: These results suggest that although PhA, IR, and RR in the whole body and lower limbs showed age-related changes, the change in PhA in the upper body was small, especially in females. However, IR and RR in the upper limbs of females reflected age-related changes more than PhA. CI - (c) 2025. The Author(s). FAU - Oshita, Kazushige AU - Oshita K AUID- ORCID: 0000-0002-8049-1174 AD - Department of Human Information Engineering, Okayama Prefectural University, Soja, Japan. oshita@ss.oka-pu.ac.jp. FAU - Hikita, Akihisa AU - Hikita A AD - Department of Sport Science, Kyushu Kyoritsu University, Kitakyushu, Japan. FAU - Myotsuzono, Ryota AU - Myotsuzono R AUID- ORCID: 0000-0002-6826-9941 AD - Department of Sport Science, Kyushu Kyoritsu University, Kitakyushu, Japan. FAU - Ishihara, Yujiro AU - Ishihara Y AD - Center for Fundamental Education, Okayama University of Science, Okayama, Japan. LA - eng GR - JP24K09636/Japan Society for the Promotion of Science/ PT - Journal Article DEP - 20250305 PL - England TA - J Physiol Anthropol JT - Journal of physiological anthropology JID - 101269653 RN - Japanese people SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - Age Factors MH - *Aging/physiology MH - *Body Composition/physiology MH - Body Mass Index MH - *Electric Impedance MH - Japan MH - *Muscle, Skeletal/physiology MH - *East Asian People/statistics & numerical data PMC - PMC11881323 OTO - NOTNLM OT - Impedance ratio OT - Muscle mass OT - Phase angle OT - Resistance ratio OT - Skeletal muscle mass index (SMI) COIS- Declarations. Ethics approval and consent to participate: This study was reviewed and approved by the Research Ethics Committee of Kyushu Kyoritsu University (approval number: 2022-08) and Okayama Prefectural University (approval number: 20-72 and 23-62), and informed consent was obtained from all the participants prior to the examination. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/03/06 05:05 MHDA- 2025/03/06 06:21 PMCR- 2025/03/05 CRDT- 2025/03/05 23:49 PHST- 2025/01/03 00:00 [received] PHST- 2025/02/23 00:00 [accepted] PHST- 2025/03/06 06:21 [medline] PHST- 2025/03/06 05:05 [pubmed] PHST- 2025/03/05 23:49 [entrez] PHST- 2025/03/05 00:00 [pmc-release] AID - 10.1186/s40101-025-00388-5 [pii] AID - 388 [pii] AID - 10.1186/s40101-025-00388-5 [doi] PST - epublish SO - J Physiol Anthropol. 2025 Mar 5;44(1):8. doi: 10.1186/s40101-025-00388-5. PMID- 40045236 OWN - NLM STAT- MEDLINE DCOM- 20250511 LR - 20250511 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Mar 5 TI - Social body weight norms: a population-based profile in Germany, the Netherlands, and the United States. PG - 876 LID - 10.1186/s12889-025-21449-5 [doi] LID - 876 AB - BACKGROUND: Which body weight is considered ideal and socially accepted in modern societies? A widely held belief is that social body weight norms are strict and thin in Western societies. This belief is supported by empirical evidence drawn from samples that do not necessarily represent common views in the population. METHODS: This study presents a population-based profile of social body weight norms using survey data collected in 2019 in the United States (N = 1,390, ages 18 to 84), Germany (N = 4,285, ages 24 to 74), and the Netherlands (N = 2,040, ages 18 to 84). Norms were measured on a validated figure rating scale. RESULTS: In all study populations, male and female figures representing the range from normal weight to slight overweight were generally rated as ideal and neither too thin nor too heavy. Heavier norms were found in older people and men, and more often in the Netherlands than in Germany and the United States. People generally perceived social body weight norms as thinner than what actual ratings revealed. This perception bias was most pronounced in the United States. CONCLUSIONS: These findings provide a population-representative baseline of social body weight norms and contradict the notion of a thinness norm. CI - (c) 2025. The Author(s). FAU - Leopold, Liliya AU - Leopold L AD - Department of Sociology, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV, Amsterdam, The Netherlands. l.leopold@uva.nl. LA - eng PT - Journal Article DEP - 20250305 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - Male MH - Netherlands MH - Germany MH - United States MH - Adult MH - Middle Aged MH - Aged MH - Adolescent MH - Young Adult MH - Aged, 80 and over MH - *Social Norms MH - *Body Weight MH - Surveys and Questionnaires MH - *Body Image/psychology PMC - PMC11884194 OTO - NOTNLM OT - Ideal body weight OT - International comparison OT - Social body weight norms OT - Weight perceptions COIS- Declarations. Ethics approval and consent to participate: The GESIS Panel, LISS, and UAS adhere to the ethical standards of their respective institutions. The GESIS Panel follows the ethical guidelines set by the GESIS Leibniz Institute for the Social Sciences [28, 29], the LISS Panel complies with the ethical standards of CentERdata [30], and the UAS adheres to the protocols established by the University of Southern California [27]. All participants provided informed consent in accordance with these ethical standards. Competing interests: The authors declare no competing interests. EDAT- 2025/03/06 05:03 MHDA- 2025/03/06 06:21 PMCR- 2025/03/05 CRDT- 2025/03/05 23:45 PHST- 2024/04/23 00:00 [received] PHST- 2025/01/14 00:00 [accepted] PHST- 2025/03/06 06:21 [medline] PHST- 2025/03/06 05:03 [pubmed] PHST- 2025/03/05 23:45 [entrez] PHST- 2025/03/05 00:00 [pmc-release] AID - 10.1186/s12889-025-21449-5 [pii] AID - 21449 [pii] AID - 10.1186/s12889-025-21449-5 [doi] PST - epublish SO - BMC Public Health. 2025 Mar 5;25(1):876. doi: 10.1186/s12889-025-21449-5. PMID- 40043714 OWN - NLM STAT- MEDLINE DCOM- 20260122 LR - 20260122 IS - 1543-2920 (Electronic) IS - 0899-8493 (Linking) VI - 38 IP - 1 DP - 2026 Feb 1 TI - Evaluation of Functional Capacity and Pulmonary Functions in Pediatric Patients With Chronic Kidney Disease: A Retrospective Study. PG - 72-79 LID - 10.1123/pes.2024-0128 [doi] AB - PURPOSE: Chronic kidney disease (CKD) affects pulmonary and cardiovascular systems. This study evaluates functional and pulmonary capacity in pediatric patients with CKD stages 1 to 5. METHODS: Medical records of 30 pediatric CKD patients (stages 1-5) from December 2019 to February 2021 were analyzed. Functional capacity was assessed with the 6-minute walk test and spirometry measured pulmonary function. Data on body mass index z scores, height z scores, and CKD etiology (congenital anomalies of the kidney and urinary tract, glomerulonephritis, or others) were included. Correlation and regression analyses evaluated relationships between CKD severity, pulmonary function, and functional capacity. RESULTS: Functional capacity worsened with CKD progression, with stage 5 patients showing the lowest 6-minute walk test distances (384 [71] m). Pulmonary function tests revealed lower forced expiratory volume in 1 second and peak expiratory flow values compared with healthy peers (P = .04, P < .001). Restrictive patterns were observed in early CKD, with obstructive changes in advanced stages. Positive correlations were noted between 6-minute walk test and forced expiratory volume in 1 second (r = .42) and peak expiratory flow (r = .48). Height z score emerged as an independent predictor of pulmonary outcomes. CONCLUSIONS: CKD progressively impairs functional and pulmonary capacity in children, especially in advanced stages. These findings underline the importance of comprehensive care focusing on physical and respiratory health. Prospective studies are needed to validate these results and develop targeted interventions. FAU - Cavusoglu, Irmak AU - Cavusoglu I AUID- ORCID: 0000-0002-0508-3189 AD - Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul,Turkey. FAU - Safran, Elif Esma AU - Safran EE AUID- ORCID: 0000-0001-9918-5604 AD - Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul,Turkey. FAU - Yavuz, Sevgi AU - Yavuz S AUID- ORCID: 0000-0002-0053-6986 AD - Department of Pediatric Nephrology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul,Turkey. LA - eng PT - Journal Article DEP - 20250305 PL - United States TA - Pediatr Exerc Sci JT - Pediatric exercise science JID - 8909729 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - *Renal Insufficiency, Chronic/physiopathology MH - Retrospective Studies MH - Walk Test MH - Adolescent MH - Respiratory Function Tests MH - *Lung/physiopathology MH - Spirometry MH - Disease Progression MH - Forced Expiratory Volume MH - Child, Preschool OTO - NOTNLM OT - 6-minute walk test OT - exercise capacity in CKD OT - pediatric nephrology OT - pediatric respiratory health OT - renal impairment in children EDAT- 2025/03/06 05:04 MHDA- 2026/01/22 19:24 CRDT- 2025/03/05 18:43 PHST- 2024/08/27 00:00 [received] PHST- 2024/12/05 00:00 [revised] PHST- 2025/01/13 00:00 [accepted] PHST- 2026/01/22 19:24 [medline] PHST- 2025/03/06 05:04 [pubmed] PHST- 2025/03/05 18:43 [entrez] AID - 10.1123/pes.2024-0128 [doi] PST - epublish SO - Pediatr Exerc Sci. 2025 Mar 5;38(1):72-79. doi: 10.1123/pes.2024-0128. Print 2026 Feb 1. PMID- 40038379 OWN - NLM STAT- MEDLINE DCOM- 20250510 LR - 20250510 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Mar 4 TI - Eating distractions as predictors of ultra-processed food consumption and Mediterranean diet adherence in adolescents. PG - 7579 LID - 10.1038/s41598-025-91754-x [doi] LID - 7579 AB - Previous studies have examined the relationships between some eating distractions and diet quality in the young population. However, to our knowledge, no study has analyzed the associations between multiple eating distractions (e.g., using a mobile phone, watching television [TV], eating while standing) and diet quality, particularly in terms of ultra-processed food (UPF) consumption and adherence to the Mediterranean diet (MedDiet) among adolescents. The objective of the current study was to analyze the relationships of eating distractions with UPF consumption and adherence to the MedDiet in a sample of Spanish adolescents. This cross-sectional study used data from 826 adolescents aged 12-17 years from the Eating Healthy and Daily Life Activities study in Spain. The following eating distractions were assessed via a self-report questionnaire: "(1) eating while talking on the phone/sending short message service [SMS]/emails or using social networks", (2) watching TV while dinner, and (3) eating while standing". The Mediterranean Diet Quality Index for children and adolescents (KIDMED) was utilized to evaluate adherence to the MedDiet. A self-administered food frequency questionnaire, previously validated for the Spanish population, was used to assess UPF consumption. The associations of eating distractions with UPF consumption and MedDiet adherence were analyzed via generalized linear models. The models were adjusted for sex, age, socioeconomic status, body mass index, physical activity, sedentary behavior, and sleep duration. A significant association was found, with a higher eating distraction score corresponding to greater UPF consumption (unstandardized beta coefficient [B] = 71.25; 95% confidence interval [CI] 34.69-107.82; p < 0.001). Furthermore, a higher eating distraction score was associated with a lower KIDMED score (B - 0.29; 95% CI - 0.39 to - 0.18; p < 0.001). Individually, for grams of UPFs consumed, a significant association was observed for eating while using a phone or social network, which was linked to higher UPF consumption (B = 120.70; 95% CI 57.83-183.57; p < 0.001). However, the associations for eating while watching TV (B = 49.60; 95% CI - 9.01 to 108.21; p = 0.098) and eating while standing (B = 63.66; 95% CI - 37.92 to 165.25; p = 0.220) did not reach statistical significance. For KIDMED score, all the eating distractions were associated with a significant decrease, with the largest effect observed for phone or social network use (B = - 0.44; 95% CI - 0.62 to - 0.26). Watching TV (B = - 0.18; 95% CI - 0.35 to - 0.01; p = 0.037) and eating while standing (B = - 0.42; 95% CI - 0.71 to - 0.13; p = 0.004) also showed significant negative associations. Although diet quality is influenced by multiple factors, eating distractions may negatively impact adolescents by increasing UPF consumption and reducing adherence to the MedDiet. These findings underscore the importance of understanding the role of the eating environment in shaping healthy dietary habits. CI - (c) 2025. The Author(s). FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AD - One Health Research Group, Universidad de Las Americas, Quito, Ecuador. Josefranciscolopezgil@gmail.com. FAU - Quiroz-Cardenas, Fiorella AU - Quiroz-Cardenas F AD - Health and Social Research Center, Universidad de Castilla-La Mancha, Cuenca, Spain. FAU - Montenegro-Espinosa, Jose Adrian AU - Montenegro-Espinosa JA AD - One Health Research Group, Universidad de Las Americas, Quito, Ecuador. FAU - Cisneros-Vasquez, Emily AU - Cisneros-Vasquez E AD - One Health Research Group, Universidad de Las Americas, Quito, Ecuador. FAU - Mino, Camila AU - Mino C AD - One Health Research Group, Universidad de Las Americas, Quito, Ecuador. FAU - Castillo-Minaca, Monica Elizabeth AU - Castillo-Minaca ME AD - One Health Research Group, Universidad de Las Americas, Quito, Ecuador. FAU - Unda-Lopez, Ruben Alejandro AU - Unda-Lopez RA AD - One Health Research Group, Universidad de Las Americas, Quito, Ecuador. FAU - Sanchez-Charcopa, Lina America AU - Sanchez-Charcopa LA AD - One Health Research Group, Universidad de Las Americas, Quito, Ecuador. FAU - Zalamea-Delgado, Maria Paula AU - Zalamea-Delgado MP AD - One Health Research Group, Universidad de Las Americas, Quito, Ecuador. FAU - Masache-Cruz, Martina Jared AU - Masache-Cruz MJ AD - One Health Research Group, Universidad de Las Americas, Quito, Ecuador. FAU - Palacios-Zavala, David Alejandro AU - Palacios-Zavala DA AD - One Health Research Group, Universidad de Las Americas, Quito, Ecuador. FAU - Barriga-Collantes, Mateo Alejandro AU - Barriga-Collantes MA AD - One Health Research Group, Universidad de Las Americas, Quito, Ecuador. FAU - Gutierrez-Espinoza, Hector AU - Gutierrez-Espinoza H AD - Faculty of Education, Universidad Autonoma de Chile, Santiago, Chile. FAU - Olivares-Arancibia, Jorge AU - Olivares-Arancibia J AD - AFySE Group, Research in Physical Activity and School Health, School of Physical Education, Faculty of Education, Universidad de Las Americas, Santiago, Chile. FAU - Yanez-Sepulveda, Rodrigo AU - Yanez-Sepulveda R AD - Faculty Education and Social Sciences, Universidad Andres Bello, Vina del Mar, Chile. FAU - Hermosa-Bosano, Carlos AU - Hermosa-Bosano C AD - Well-Being, Health and Society Research Group, School of Psychology and Education, Universidad de Las Americas, Quito, Ecuador. LA - eng PT - Journal Article DEP - 20250304 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Adolescent MH - *Diet, Mediterranean MH - Female MH - Male MH - Child MH - *Feeding Behavior/psychology MH - Cross-Sectional Studies MH - Spain MH - *Fast Foods MH - Surveys and Questionnaires MH - *Eating/psychology MH - Self Report MH - Food, Processed PMC - PMC11880373 OTO - NOTNLM OT - Distracted eating OT - Eating healthy OT - Mindful eating OT - NOVA OT - Youths COIS- Declarations. Competing interests: The authors declare no competing interests. Consent statement: Informed consent was obtained from all the participants. Ethical approval: This study was conducted in accordance with the Declaration of Helsinki. This study was approved by the Bioethics Committee of the University of Murcia (approval ID 2218/2018, approved on 18 February 2019) and the Ethics Committee of the Albacete University Hospital Complex (approval ID 2021-85, approved on 23 November 2021). EDAT- 2025/03/05 00:21 MHDA- 2025/03/05 00:22 PMCR- 2025/03/04 CRDT- 2025/03/04 23:31 PHST- 2024/12/10 00:00 [received] PHST- 2025/02/24 00:00 [accepted] PHST- 2025/03/05 00:22 [medline] PHST- 2025/03/05 00:21 [pubmed] PHST- 2025/03/04 23:31 [entrez] PHST- 2025/03/04 00:00 [pmc-release] AID - 10.1038/s41598-025-91754-x [pii] AID - 91754 [pii] AID - 10.1038/s41598-025-91754-x [doi] PST - epublish SO - Sci Rep. 2025 Mar 4;15(1):7579. doi: 10.1038/s41598-025-91754-x. PMID- 40034234 OWN - NLM STAT- MEDLINE DCOM- 20250511 LR - 20250512 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 16 DP - 2025 TI - Impact of segmental body composition on metabolic dysfunction-associated fatty liver disease in Chinese children. PG - 1505050 LID - 10.3389/fendo.2025.1505050 [doi] LID - 1505050 AB - PURPOSE: This study aimed to assess the relationship between regional body composition and metabolic dysfunction-associated fatty liver disease (MAFLD) in Chinese children. METHODS: In this study, 1399 children aged 7-14 years were included. Liver steatosis was assessed using the controlled attenuation parameter (CAP) measured through Fibroscan. MAFLD is defined as the presence of liver steatosis along with either overweight/obesity, prediabetes/diabetes, or at least two metabolic index abnormalities. Regression analyses were applied to assess the relationship between regional body composition and MAFLD in children. Subgroup analyses were performed based on sex and weight. RESULTS: The participants had a mean age of 9 years, with 52.11% being boys. Among them, 134 (9.57%) were diagnosed with MAFLD, and 17 (1.22%) had severe fatty liver disease. We found an inverse correlation between the muscle percentage in each region and MAFLD, with the extremities demonstrating the most significant negative correlation (OR: 0.732; 95% CI: 0.634-0.844). Conversely, regional fat was positively associated with MAFLD, with the strongest correlation found in the upper limbs (OR: 3.104; 95% CI: 2.023-4.764). Subgroup analyses showed similar results. CONCLUSION: The decrease in regional muscle percentage, particularly in the limbs, along with the increase in regional fat percentage, especially in the upper limbs, is associated with a higher probability of developing MAFLD in prepubertal children. Additional prospective studies are needed to strengthen and validate these findings. CI - Copyright (c) 2025 Hu, Sun, Yang, Zheng, Wu, Zhang, Yao, Zhang and Zhang. FAU - Hu, Meng-Yuan AU - Hu MY AD - Department of Paediatrics, Affiliated Children's Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi, Jiangsu, China. FAU - Sun, Dan-Qin AU - Sun DQ AD - Urologic Nephrology Center, Jiangnan University Medical Center, Wuxi, Jiangsu, China. FAU - Yang, Fan AU - Yang F AD - Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China. FAU - Zheng, Xiao-Wei AU - Zheng XW AD - Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China. FAU - Wu, Ning-Xi AU - Wu NX AD - Department of Paediatrics, Affiliated Children's Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi, Jiangsu, China. FAU - Zhang, Hao-Yang AU - Zhang HY AD - Department of Paediatrics, Affiliated Children's Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi, Jiangsu, China. FAU - Yao, Xiao-Die AU - Yao XD AD - Department of Paediatrics, Affiliated Children's Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi, Jiangsu, China. FAU - Zhang, Jia-Hui AU - Zhang JH AD - Department of Paediatrics, Affiliated Children's Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi, Jiangsu, China. FAU - Zhang, Le AU - Zhang L AD - Department of Paediatrics, Affiliated Children's Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi, Jiangsu, China. LA - eng PT - Journal Article DEP - 20250217 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - Chinese people SB - IM MH - Humans MH - Child MH - Male MH - Female MH - Adolescent MH - *Body Composition/physiology MH - China/epidemiology MH - *Non-alcoholic Fatty Liver Disease/epidemiology MH - Cross-Sectional Studies MH - *Metabolic Diseases/epidemiology MH - *Fatty Liver/epidemiology MH - East Asian People PMC - PMC11872705 OTO - NOTNLM OT - BIA OT - Fibroscan OT - MAFLD OT - children OT - regional body composition COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/03/04 10:53 MHDA- 2025/03/04 10:54 PMCR- 2025/01/01 CRDT- 2025/03/04 04:46 PHST- 2024/10/02 00:00 [received] PHST- 2025/01/29 00:00 [accepted] PHST- 2025/03/04 10:54 [medline] PHST- 2025/03/04 10:53 [pubmed] PHST- 2025/03/04 04:46 [entrez] PHST- 2025/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2025.1505050 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2025 Feb 17;16:1505050. doi: 10.3389/fendo.2025.1505050. eCollection 2025. PMID- 40033007 OWN - NLM STAT- MEDLINE DCOM- 20250510 LR - 20250905 IS - 2522-5812 (Electronic) IS - 2522-5812 (Linking) VI - 7 IP - 3 DP - 2025 Mar TI - A western dietary pattern during pregnancy is associated with neurodevelopmental disorders in childhood and adolescence. PG - 586-601 LID - 10.1038/s42255-025-01230-z [doi] AB - Despite the high prevalence of neurodevelopmental disorders, the influence of maternal diet during pregnancy on child neurodevelopment remains understudied. Here we show that a western dietary pattern during pregnancy is associated with child neurodevelopmental disorders. We analyse self-reported maternal dietary patterns at 24 weeks of pregnancy and clinically evaluated neurodevelopmental disorders at 10 years of age in the COPSAC2010 cohort (n = 508). We find significant associations with attention-deficit hyperactivity disorder (ADHD) and autism diagnoses. We validate the ADHD findings in three large, independent mother-child cohorts (n = 59,725, n = 656 and n = 348) through self-reported dietary modelling, maternal blood metabolomics and foetal blood metabolomics. Metabolome analyses identify 15 mediating metabolites in pregnancy that improve ADHD prediction. Longitudinal blood metabolome analyses, incorporating five time points per cohort in two independent cohorts, reveal that associations between western dietary pattern metabolite scores and neurodevelopmental outcomes are consistently significant in early-mid-pregnancy. These findings highlight the potential for targeted prenatal dietary interventions to prevent neurodevelopmental disorders and emphasise the importance of early intervention. CI - (c) 2025. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Horner, David AU - Horner D AUID- ORCID: 0000-0002-0200-4561 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. david.horner@dbac.dk. FAU - Jepsen, Jens Richardt M AU - Jepsen JRM AD - Center for Neuropsychiatric Schizophrenia Research (CNSR) and Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark. AD - Mental Health Centre for Child and Adolescent Psychiatry - Research unit, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark. FAU - Chawes, Bo AU - Chawes B AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. FAU - Aagaard, Kristina AU - Aagaard K AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. FAU - Rosenberg, Julie B AU - Rosenberg JB AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. AD - Center for Neuropsychiatric Schizophrenia Research (CNSR) and Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark. AD - Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Mohammadzadeh, Parisa AU - Mohammadzadeh P AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. AD - Center for Neuropsychiatric Schizophrenia Research (CNSR) and Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark. AD - Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Sevelsted, Astrid AU - Sevelsted A AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. FAU - Vahman, Nilo AU - Vahman N AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. FAU - Vinding, Rebecca AU - Vinding R AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. FAU - Fagerlund, Birgitte AU - Fagerlund B AUID- ORCID: 0000-0003-4547-2944 AD - Center for Neuropsychiatric Schizophrenia Research (CNSR) and Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark. AD - Department of Psychology, University of Copenhagen, Copenhagen, Denmark. FAU - Pantelis, Christos AU - Pantelis C AUID- ORCID: 0000-0002-9565-0238 AD - Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia. AD - Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia. FAU - Bilenberg, Niels AU - Bilenberg N AD - Institute of Clinical Research, University of Southern Denmark, Odense, Denmark. FAU - Pedersen, Casper-Emil T AU - Pedersen CT AUID- ORCID: 0000-0003-2540-5373 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. FAU - Eliasen, Anders AU - Eliasen A AUID- ORCID: 0000-0003-2629-0790 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. AD - Department of Health Technology, Section for Bioinformatics, Technical University of Denmark, Kgs. Lyngby, Denmark. FAU - Brandt, Sarah AU - Brandt S AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. FAU - Chen, Yulu AU - Chen Y AD - Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Prince, Nicole AU - Prince N AUID- ORCID: 0000-0002-8506-1122 AD - Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Chu, Su H AU - Chu SH AUID- ORCID: 0000-0002-6345-008X AD - Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Kelly, Rachel S AU - Kelly RS AUID- ORCID: 0000-0003-3023-1822 AD - Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Lasky-Su, Jessica AU - Lasky-Su J AD - Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Halldorsson, Thorhallur I AU - Halldorsson TI AD - Faculty of Food Science and Nutrition, School of Health Science, University of Iceland, Health Science Institute, Unit for Nutrition Research, Reykjavik, Iceland. AD - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. FAU - Strom, Marin AU - Strom M AD - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. AD - Faculty of Health Sciences, University of the Faroe Islands, Torshavn, Faroe Islands. FAU - Strandberg-Larsen, Katrine AU - Strandberg-Larsen K AD - Section of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. FAU - Olsen, Sjurdur F AU - Olsen SF AD - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. AD - Faculty of Health Sciences, University of the Faroe Islands, Torshavn, Faroe Islands. AD - Section of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. AD - Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA. FAU - Glenthoj, Birte Y AU - Glenthoj BY AUID- ORCID: 0000-0003-3056-7262 AD - Center for Neuropsychiatric Schizophrenia Research (CNSR) and Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark. AD - Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Bonnelykke, Klaus AU - Bonnelykke K AUID- ORCID: 0000-0003-2003-1018 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. FAU - Ebdrup, Bjorn H AU - Ebdrup BH AD - Center for Neuropsychiatric Schizophrenia Research (CNSR) and Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark. AD - Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Stokholm, Jakob AU - Stokholm J AUID- ORCID: 0000-0003-4989-9769 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. AD - Section of Food Microbiology, Gut Health and Fermentation, Department of Food Science, University of Copenhagen, Copenhagen, Denmark. FAU - Rasmussen, Morten Arendt AU - Rasmussen MA AUID- ORCID: 0000-0001-7431-5206 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. morten.arendt@dbac.dk. AD - Section of Food Microbiology, Gut Health and Fermentation, Department of Food Science, University of Copenhagen, Copenhagen, Denmark. morten.arendt@dbac.dk. LA - eng GR - K01 HL153941/HL/NHLBI NIH HHS/United States GR - R01 HL123915/HL/NHLBI NIH HHS/United States GR - R01 HL155742/HL/NHLBI NIH HHS/United States GR - R01 HL141826/HL/NHLBI NIH HHS/United States GR - K01 HL175261/HL/NHLBI NIH HHS/United States GR - R269-2017-5/Lundbeckfonden (Lundbeck Foundation)/ GR - K01 HL146980/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20250303 PL - Germany TA - Nat Metab JT - Nature metabolism JID - 101736592 SB - IM UOF - medRxiv. 2024 Jun 25:2024.03.07.24303907. doi: 10.1101/2024.03.07.24303907. PMID: 38496582 MH - Humans MH - Pregnancy MH - Female MH - Child MH - *Neurodevelopmental Disorders/etiology/epidemiology MH - Adolescent MH - *Diet, Western/adverse effects MH - Male MH - *Prenatal Exposure Delayed Effects MH - Attention Deficit Disorder with Hyperactivity/etiology/epidemiology MH - Metabolome MH - Metabolomics MH - Adult MH - Cohort Studies MH - Longitudinal Studies PMC - PMC12022897 MID - NIHMS2072600 COIS- Ethics statement: The study is conducted in accordance with the Declaration of Helsinki and was approved by the Danish Ethics Committee (H-B-2008-093) and the Danish Data Protection Agency (2015-41-3696). The study is conducted and monitored in accordance with the requirements of GCP as defined in guidelines, EU Clinical Trials Directive (2001/20/EC) and EU GCP Directive (2005/28/EC). All study participants have signed approved informed consent forms before any study-related procedures. The confidentiality of all study participants will be protected in accordance with GCP guidelines. Competing interests: B.E. is part of the Advisory Board of Eli Lilly Denmark A/S, Janssen-Cilag, Lundbeck Pharma A/S, and Takeda Pharmaceutical Company; and has received lecture fees from Bristol-Myers Squibb, Boehringer Ingelheim, Otsuka Pharma Scandinavia AB, Eli Lilly Company and Lundbeck Pharma A/S. B.Y.G. has been the leader of a Lundbeck Foundation Centre of Excellence for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) (January 2009 to December 2021), which was partially financed by an independent grant from the Lundbeck Foundation based on international review and partially financed by the Mental Health Services in the Capital Region of Denmark, the University of Copenhagen and other foundations. All grants are the property of the Mental Health Services in the Capital Region of Denmark and administered by them. She has no other conflicts to disclose. J.L.-S. is a scientific advisor for Precion and a consultant to Tru Diagnostic. All other authors declare no competing interests. The funding agencies did not have any role in design and conduct of the study; collection, management and interpretation of the data; or preparation, review or approval of the paper. No pharmaceutical company was involved in the study. EDAT- 2025/03/04 00:21 MHDA- 2025/03/27 06:28 PMCR- 2025/09/03 CRDT- 2025/03/03 23:33 PHST- 2024/09/01 00:00 [received] PHST- 2025/02/06 00:00 [accepted] PHST- 2025/03/27 06:28 [medline] PHST- 2025/03/04 00:21 [pubmed] PHST- 2025/03/03 23:33 [entrez] PHST- 2025/09/03 00:00 [pmc-release] AID - 10.1038/s42255-025-01230-z [pii] AID - 10.1038/s42255-025-01230-z [doi] PST - ppublish SO - Nat Metab. 2025 Mar;7(3):586-601. doi: 10.1038/s42255-025-01230-z. Epub 2025 Mar 3. PMID- 40028670 OWN - NLM STAT- MEDLINE DCOM- 20250503 LR - 20260818 IS - 1463-1326 (Electronic) IS - 1462-8902 (Print) IS - 1462-8902 (Linking) VI - 27 IP - 6 DP - 2025 Jun TI - Trends in obesity and glucagon-like peptide-1 receptor agonist prescriptions in type 1 diabetes in the United States. PG - 2967-2976 LID - 10.1111/dom.16300 [doi] AB - AIMS: To characterize trends in obesity and prescriptions for glucagon-like peptide-1 receptor agonists (GLP-1RAs) across body mass index (BMI) categories among US youth and adults with type 1 diabetes (T1D) from 2008 to 2023. MATERIALS AND METHODS: Patients with T1D were identified using a validated algorithm using de-identified electronic health record (EHRs) data from 33 US health systems. BMI categories were based on age- and sex-specific percentiles for youth (2-19 years) and World Health Organization cut points for adults (>/=20 years). Trends in obesity and GLP1-RA prescriptions were characterized by BMI categories among youth and adults with T1D from 2008-2011 to 2020-2023. RESULTS: From 2008-2011 to 2020-2023, the prevalence of obesity among youth with T1D increased from 18.1% (95% confidence interval [CI], 17.3%-18.9%) to 26.0% (25.2%-26.8%) (p-for-trend < 0.001). Among adults with T1D, the prevalence of obesity rose from 30.5% (30.0%-31.0%) in 2008-2011 to 38.1% (37.8%-38.5%) in 2020-2023 (p-for-trend < 0.001). Obesity was highest in Black and Hispanic youth and adults, and racial and ethnic disparities persisted over time. Over the last 15-year period, GLP-1RA prescriptions significantly increased across all BMI categories in a dose-response manner among both youth and adults with T1D (all p-for-trend < 0.001). CONCLUSIONS: Over the last 15-year period, obesity has reached epidemic levels in US youth and adults with T1D, with significant disparities among racial and ethnic minoritized populations. These findings, coupled with the increase in GLP-1RA prescriptions, underscore the urgent need for data on GLP-1RAs' safety and effectiveness and guidance for obesity management in T1D. CI - (c) 2025 John Wiley & Sons Ltd. FAU - Xu, Yunwen AU - Xu Y AD - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Echouffo Tcheugui, Justin B AU - Echouffo Tcheugui JB AUID- ORCID: 0000-0002-8460-1617 AD - Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. FAU - Coresh, Josef AU - Coresh J AD - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. AD - Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA. FAU - Grams, Morgan E AU - Grams ME AD - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. AD - Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA. AD - Division of Precision Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA. FAU - Selvin, Elizabeth AU - Selvin E AUID- ORCID: 0000-0001-6923-7151 AD - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Fang, Michael AU - Fang M AD - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Shin, Jung-Im AU - Shin JI AUID- ORCID: 0000-0003-0374-6927 AD - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. LA - eng GR - K01 DK138273/DK/NIDDK NIH HHS/United States GR - K24 HL155861/HL/NHLBI NIH HHS/United States GR - R01 DK115534/DK/NIDDK NIH HHS/United States GR - R01 DK139324/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20250303 PL - England TA - Diabetes Obes Metab JT - Diabetes, obesity & metabolism JID - 100883645 RN - 0 (Glucagon-Like Peptide-1 Receptor Agonists) RN - 0 (Hypoglycemic Agents) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/drug therapy/epidemiology/complications MH - Adolescent MH - Male MH - Female MH - United States/epidemiology MH - Young Adult MH - *Glucagon-Like Peptide-1 Receptor Agonists MH - Child MH - Adult MH - *Obesity/epidemiology/complications MH - *Hypoglycemic Agents/therapeutic use MH - Body Mass Index MH - Child, Preschool MH - Prevalence MH - Drug Prescriptions/statistics & numerical data MH - Middle Aged PMC - PMC12049267 MID - NIHMS2060588 OTO - NOTNLM OT - body mass index OT - glucagon-like peptide-1 receptor agonists OT - obesity OT - type 1 diabetes mellitus COIS- Disclosures: All authors do not have conflicts of interest relevant to this article. EDAT- 2025/03/03 17:13 MHDA- 2025/05/03 22:26 PMCR- 2026/06/01 CRDT- 2025/03/03 06:39 PHST- 2025/02/06 00:00 [revised] PHST- 2024/11/27 00:00 [received] PHST- 2025/02/15 00:00 [accepted] PHST- 2025/05/03 22:26 [medline] PHST- 2025/03/03 17:13 [pubmed] PHST- 2025/03/03 06:39 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - 10.1111/dom.16300 [doi] PST - ppublish SO - Diabetes Obes Metab. 2025 Jun;27(6):2967-2976. doi: 10.1111/dom.16300. Epub 2025 Mar 3. PMID- 40025577 OWN - NLM STAT- MEDLINE DCOM- 20250510 LR - 20250510 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 13 IP - 1 DP - 2025 Mar 1 TI - A study on the relationship between high school students' sleep quality, physical exercise, academic stress, and subjective well-being. PG - 180 LID - 10.1186/s40359-025-02497-3 [doi] LID - 180 AB - OBJECTIVE: This Research explores the intermediary function of academic stress and sleep quality in the connection between physical exercise and subjective well-being among high school students. METHODS: This Research conducted an online survey through random sampling with a sample of 540 (males = 310, females = 217; grade 10 = 159, grade 11 = 190, grade 12 = 178) high school students to explore the intermediary function of academic stress and sleep quality between physical exercise and subjective well-being. The participants were surveyed using PSQI, the Subjective Well-Being Scale, the ESSA, and PSQI. SPSS Statistics 26 was used to conduct reliability and validity tests, descriptive statistics, and correlation analysis. Mediation analysis was conducted utilizing Model 6 from the PROCESS 4.0 plugin. RESULTS: (1) Physical exercise shows a significant positive correlation with subjective well-being, and the direct impact of physical exercise on subjective well-being is also significant. (2) Physical exercise adversely affects academic stress and positively influences sleep quality. Academic stress negatively impacts sleep quality and subjective well-being, while sleep quality positively influences subjective well-being. (3) Academic stress and sleep quality serve as significant mediators between physical exercise and subjective well-being. The mediation effect encompasses two indirect paths: In one aspect, physical exercise has an indirect impact on subjective well-being through its influence on academic stress; in another aspect, physical exercise indirectly affects subjective well-being via the chain mediation effects of academic stress and sleep quality. CONCLUSION: Physical exercise can directly influence the subjective well-being of high school students. Additionally, physical exercise can indirectly impact their subjective well-being through academic stress, and it can also indirectly influence their subjective well-being through the chain mediation effect of academic stress and sleep quality. Based on these findings, it is recommended that schools provide more opportunities for physical exercise, integrated with psychological counseling and sleep management, to help students effectively alleviate academic stress, thereby enhancing their overall well-being. CI - (c) 2025. The Author(s). FAU - Cheng, Ruirui AU - Cheng R AD - College of Physical Education, Shangqiu Normal University, Shangqiu, 476000, Henan, China. FAU - Yang, Lei AU - Yang L AD - College of Physical Education, Shangqiu Normal University, Shangqiu, 476000, Henan, China. FAU - Kang, Suh-Jung AU - Kang SJ AD - College of Culture and Arts, Sangmyung University, Seoul, 03016, Republic of Korea. suhjkang@163.com. LA - eng PT - Journal Article DEP - 20250301 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Adolescent MH - Male MH - *Exercise/psychology MH - Female MH - *Sleep Quality MH - *Students/psychology MH - *Stress, Psychological/psychology MH - Surveys and Questionnaires MH - Schools MH - *Personal Satisfaction PMC - PMC11872323 OTO - NOTNLM OT - Academic stress OT - Physical exercise OT - Sleep quality OT - Subjective well-being COIS- Declarations. Ethics approval and consent to participate: The researchers confirms that all research was performed in accordance with relevant guidelines/regulations applicable when human participants are involved (e.g., Declaration of Helsinki or similar). This study was approved by the Ethics Committee of Shangqiu Normal University. The participants received oral and written information and provided written informed consent before participating in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/03/03 00:56 MHDA- 2025/03/03 06:21 PMCR- 2025/03/01 CRDT- 2025/03/02 23:42 PHST- 2024/10/08 00:00 [received] PHST- 2025/02/17 00:00 [accepted] PHST- 2025/03/03 06:21 [medline] PHST- 2025/03/03 00:56 [pubmed] PHST- 2025/03/02 23:42 [entrez] PHST- 2025/03/01 00:00 [pmc-release] AID - 10.1186/s40359-025-02497-3 [pii] AID - 2497 [pii] AID - 10.1186/s40359-025-02497-3 [doi] PST - epublish SO - BMC Psychol. 2025 Mar 1;13(1):180. doi: 10.1186/s40359-025-02497-3. PMID- 40025528 OWN - NLM STAT- MEDLINE DCOM- 20250510 LR - 20250510 IS - 1472-6823 (Electronic) IS - 1472-6823 (Linking) VI - 25 IP - 1 DP - 2025 Mar 3 TI - Accuracy of anthropometric parameters in predicting prediabetes among adolescents in Eastern Sudan: a community-based cross-sectional study. PG - 58 LID - 10.1186/s12902-025-01890-8 [doi] LID - 58 AB - INTRODUCTION: The global increase of prediabetes and diabetes in adolescents raises the issue of early prediction of this metabolic disorder via anthropometric parameters, especially in limited resources settings such as Sudan. However, the reliability of these anthropometric predictors is inconclusive. This study aimed to examine the association between anthropometric measures, including body mass index (BMI), hip circumference (HC), waist circumference (WC), waist-to-hip ratio (WHR), body roundness index (BRI), and a body shape index (ABSI), and prediabetes in adolescents in eastern Sudan. METHODS: This community-based cross-sectional study was conducted among adolescents in Gadarif City, Eastern Sudan. A questionnaire was used to collect sociodemographic information. Anthropometric and glycated hemoglobin (HbA1c) were performed following the standard procedures. The Receiver Operating Characteristic (ROC) curve was generated. Multivariate binary regression analysis was performed. RESULTS: Among the 401 adolescents, 186 (46.4%) were female, and 215 (53.6%) were male. The median (IQR) age was 14.1 (12.1-16.3) years. There was no correlation between BMI, WC, HC, WHR, BRI, ABSI, and HbA1c levels. Ninety-five (23.7%) adolescents were identified with prediabetes and 10 (2.5%) with diabetes. In univariate analysis, BRI (OR = 1.24, 95.0% CI = 1.01‒1.52) and BMI (OR = 1.05, 95.0% CI = 1.01‒1.10) were associated with prediabetes. The other anthropometrics and sociodemographic parameters were not associated with prediabetes. In multivariate analysis, BRI and BMI were not associated with prediabetes. All the tested anthropometric parameters, WHR (AUC = 0.51, cutoff = 0.80, sensitivity = 0.69, specificity = 0.44), BRI (AUC = 0.57, cutoff = 1.77, sensitivity = 0.77, specificity = 0.42), ABSI (AUC = 0.51, cutoff = 0.14, sensitivity = 0.77, specificity = 0.31), BMI (AUC = 0.55, cutoff = 18.30 kg/m(2), sensitivity = 0.45, specificity = 0.67), HC (AUC = 0.54, cutoff = 75.75 cm, sensitivity = 0.73, specificity = 0.36), and WC (AUC = 0.55, cutoff = 66.63 cm, sensitivity = 0.49, specificity = 0.63), had poor reliability in detecting prediabetes in adolescents. CONCLUSION: This study demonstrated a lack of reliability of anthropometric parameters in predicting prediabetes among adolescents in eastern Sudan. Further extensive research is recommended in various regions of Sudan. CI - (c) 2025. The Author(s). FAU - El-Gendy, Ola A AU - El-Gendy OA AD - Department of Physiology, College of Medicine, Qassim University, Buraidah, Saudi Arabia. FAU - Alsafi, Walaa M AU - Alsafi WM AD - Gadarif University, El-Gadarif, Sudan. FAU - Al-Shafei, Khadijah A AU - Al-Shafei KA AD - Royal College of Surgeons in Ireland - Bahrain (RCSI-Bahrain), Medical University of Bahrain, Busaiteen, Bahrain. FAU - Hassan, Ahmed A AU - Hassan AA AD - Faculty of Medicine, University of Khartoum, Khartoum, Sudan. aa801181@gmail.com. FAU - Adam, Ishag AU - Adam I AD - Department of Obstetrics and Gynecology, College of Medicine, Qassim University, Buraidah, Saudi Arabia. LA - eng PT - Journal Article DEP - 20250303 PL - England TA - BMC Endocr Disord JT - BMC endocrine disorders JID - 101088676 RN - 0 (Glycated Hemoglobin) SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - Cross-Sectional Studies MH - Sudan/epidemiology MH - *Prediabetic State/diagnosis/epidemiology MH - *Body Mass Index MH - *Anthropometry/methods MH - *Waist Circumference MH - Child MH - Glycated Hemoglobin/analysis MH - Prognosis MH - Waist-Hip Ratio MH - Follow-Up Studies PMC - PMC11874620 OTO - NOTNLM OT - Adolescents OT - Age OT - Anthropometric parameters OT - Diabetes OT - Prediabetes OT - Sudan COIS- Declarations. Ethics approval and Consent to Participate: This study was conducted following the principles outlined in the Declaration of Helsinki and adhered to good clinical research practices. Ethical approval was granted by the ethical research committee of the Faculty of Medicine at the University of Gadarif in Gadarif, eastern Sudan (Ref. #2023, 14). Written informed consent was obtained from all adolescents and their guardians. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/03/03 00:57 MHDA- 2025/03/03 06:22 PMCR- 2025/03/03 CRDT- 2025/03/02 23:39 PHST- 2025/01/03 00:00 [received] PHST- 2025/02/25 00:00 [accepted] PHST- 2025/03/03 06:22 [medline] PHST- 2025/03/03 00:57 [pubmed] PHST- 2025/03/02 23:39 [entrez] PHST- 2025/03/03 00:00 [pmc-release] AID - 10.1186/s12902-025-01890-8 [pii] AID - 1890 [pii] AID - 10.1186/s12902-025-01890-8 [doi] PST - epublish SO - BMC Endocr Disord. 2025 Mar 3;25(1):58. doi: 10.1186/s12902-025-01890-8. PMID- 40023998 OWN - NLM STAT- MEDLINE DCOM- 20250510 LR - 20250510 IS - 1090-2414 (Electronic) IS - 0147-6513 (Linking) VI - 292 DP - 2025 Mar 1 TI - Exposure to urinary polycyclic aromatic hydrocarbon metabolites for the effect of lung function among children and adolescents: Epidemiological study and mechanism exploration. PG - 117990 LID - S0147-6513(25)00326-4 [pii] LID - 10.1016/j.ecoenv.2025.117990 [doi] AB - Human are widely exposed to polycyclic aromatic hydrocarbon (PAHs), but existing evidence about exposure to urinary PAHs metabolites for pulmonary health in children and adolescents is limited. Our aim was to examine the effect of single and mixed exposure of urinary PAHs metabolites on lung function among children and adolescents. We included 1417 individuals aged 6-19 years from 3 survey cycles (2007-2008, 2009-2010, 2011-2012) of NHANES program. Multivariable linear regression model was conducted to examine the relationship between urinary PAHs metabolites and lung function index including FEV(1), FVC and FEV(1)/FVC. BKMR and WQS model were used to evaluate the joint effects of PAHs metabolites for lung function index. Mediation analyses were performed to investigate the mediating role of inflammation related index. Hub proteins were screened by network toxicology and validated using molecular docking. Our results indicated that 3-FLU was negatively linked with FEV(1) and FEV(1)/FVC; 1-OHP was negatively linked with FEV(1); 1-PYR was negatively linked with FEV(1) and FVC. In addition, 3-OHP was positively corrected with three lung function parameters. In BKMR and WQS models, PAHs metabolites co-exposure was all negatively corrected with FEV(1) and FVC. Systemic inflammation response index mediated the relationship between I-PYR and FEV(1) as well as FVC, with the 8 % and 6 % proportion. IL-6, STAT3, TNF, and TP53 were screened and validated as the common targets related with PAHs, inflammation and lung function by molecular docking analysis. Taken together, our findings raise the concerns about the potential hazards of environmentally relevant PAHs metabolites exposure for respiratory system in the vulnerable population and guide future research into the toxic mechanisms of PAHs metabolites-mediated lung function injury, which has important public health implications. CI - Copyright (c) 2025. Published by Elsevier Inc. FAU - Liu, Bin AU - Liu B AD - Department of Nutrition and Food Hygiene, College of Public Health, Key Laboratory of Precision nutrition and health, Ministry of Education, Harbin Medical University, Harbin, China. FAU - Zhao, Xue AU - Zhao X AD - Department of Nutrition and Food Hygiene, College of Public Health, Key Laboratory of Precision nutrition and health, Ministry of Education, Harbin Medical University, Harbin, China. FAU - He, Hongqi AU - He H AD - Department of Nutrition and Food Hygiene, College of Public Health, Key Laboratory of Precision nutrition and health, Ministry of Education, Harbin Medical University, Harbin, China. FAU - Zhou, Linwei AU - Zhou L AD - Department of Nutrition and Food Hygiene, College of Public Health, Key Laboratory of Precision nutrition and health, Ministry of Education, Harbin Medical University, Harbin, China. FAU - Fan, Yuhan AU - Fan Y AD - Department of Nutrition and Food Hygiene, College of Public Health, Key Laboratory of Precision nutrition and health, Ministry of Education, Harbin Medical University, Harbin, China. FAU - Chai, Xu AU - Chai X AD - Department of Nutrition and Food Hygiene, College of Public Health, Key Laboratory of Precision nutrition and health, Ministry of Education, Harbin Medical University, Harbin, China. FAU - Xu, Xin AU - Xu X AD - Department of Nutrition and Food Hygiene, College of Public Health, Key Laboratory of Precision nutrition and health, Ministry of Education, Harbin Medical University, Harbin, China. FAU - Gong, Xinjie AU - Gong X AD - Department of Nutrition and Food Hygiene, College of Public Health, Key Laboratory of Precision nutrition and health, Ministry of Education, Harbin Medical University, Harbin, China. FAU - An, Shuli AU - An S AD - Department of Nutrition and Food Hygiene, College of Public Health, Key Laboratory of Precision nutrition and health, Ministry of Education, Harbin Medical University, Harbin, China. FAU - Ling, Xiaodong AU - Ling X AD - Department of Thoracic Surgery, Harbin Medical University Cancer Hospital, Harbin, China. Electronic address: xiaodongling@hrbhmu.edu.cn. FAU - Chu, Xia AU - Chu X AD - Department of Nutrition and Food Hygiene, College of Public Health, Key Laboratory of Precision nutrition and health, Ministry of Education, Harbin Medical University, Harbin, China. Electronic address: cx831128@hrbmu.edu.cn. LA - eng PT - Journal Article DEP - 20250301 PL - Netherlands TA - Ecotoxicol Environ Saf JT - Ecotoxicology and environmental safety JID - 7805381 RN - 0 (Polycyclic Aromatic Hydrocarbons) RN - 0 (Environmental Pollutants) SB - IM MH - Humans MH - *Polycyclic Aromatic Hydrocarbons/urine/toxicity MH - Child MH - Adolescent MH - Male MH - Female MH - *Lung/drug effects/physiology MH - *Environmental Exposure MH - *Environmental Pollutants/urine MH - Young Adult MH - Respiratory Function Tests MH - Molecular Docking Simulation MH - Nutrition Surveys OTO - NOTNLM OT - Children and adolescents OT - Combined effect OT - Lung function OT - Molecular docking OT - Network toxicology OT - Polycyclic aromatic hydrocarbon COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/03/03 00:56 MHDA- 2025/03/16 12:44 CRDT- 2025/03/02 18:05 PHST- 2024/12/16 00:00 [received] PHST- 2025/02/21 00:00 [revised] PHST- 2025/02/25 00:00 [accepted] PHST- 2025/03/16 12:44 [medline] PHST- 2025/03/03 00:56 [pubmed] PHST- 2025/03/02 18:05 [entrez] AID - S0147-6513(25)00326-4 [pii] AID - 10.1016/j.ecoenv.2025.117990 [doi] PST - ppublish SO - Ecotoxicol Environ Saf. 2025 Mar 1;292:117990. doi: 10.1016/j.ecoenv.2025.117990. Epub 2025 Mar 1. PMID- 40020970 OWN - NLM STAT- MEDLINE DCOM- 20250510 LR - 20260528 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 208 DP - 2025 Apr 1 TI - Eating behavior profiles in infancy and their associations with parental feeding practices and rapid weight gain. PG - 107933 LID - S0195-6663(25)00086-8 [pii] LID - 10.1016/j.appet.2025.107933 [doi] AB - Childhood overweight and obesity are significant public health concerns. Eating behavior profiles using person-centered analysis have been utilized to understand patterns of commonly co-occurring eating behaviors within subgroups of individuals. However, eating behavior profiles, particularly in infancy, remain largely unexplored. Therefore, the aims of this study were to investigate person-centered eating behavior profiles in infants and their associations with infant and parental factors and rapid weight gain (RWG). Online survey included validated measures of infant eating behaviors and parental feeding practices. Infant height/length and weight were reported by parents and used to calculate RWG. Latent profile analysis was used to identify eating behavior profiles. Multiple regression analysis was performed to investigate the associations between parental feeding practices, RWG and eating behavior profiles. Chi-square was used to examine associations between demographics, milk type and eating behavior profiles. A total of 1092 parents of infants under 4 months of age (540 boys, 552 girls) completed the survey. Three unique eating behavior profiles were identified: Food Avoidance (24%, n = 263), Balanced Eating (58%, n = 633), and Food Approach (18%, n = 196). Use of food (milk) to calm was positively associated with the Food Approach profile (p < 0.001) and parental-led feeding with the Food Avoidance profile (p < 0.05). RWG was not associated with eating behavior profiles (p > 0.05). This study indicates that eating behavior profiles emerge in infants under four months old. The findings of this study will advance our knowledge of heterogeneity in infant eating and development and the environmental influences by parental feeding practices. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Lee, Jookyeong AU - Lee J AD - Deakin University, Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Geelong, VIC, Australia. Electronic address: tracy.lee@deakin.edu.au. FAU - Russell, Catherine G AU - Russell CG AD - Deakin University, Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Geelong, VIC, Australia. FAU - Burnett, Alissa J AU - Burnett AJ AD - Deakin University, Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Geelong, VIC, Australia. LA - eng PT - Journal Article DEP - 20250226 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Male MH - Infant MH - Female MH - *Feeding Behavior/psychology MH - *Weight Gain MH - Parents MH - *Parenting/psychology MH - *Infant Behavior/psychology MH - Surveys and Questionnaires MH - Adult MH - Pediatric Obesity OTO - NOTNLM OT - Appetitive traits OT - Eating behavior profiles OT - Feeding practices OT - Infants OT - Rapid weight gain COIS- Declaration of competing interest The authors declare no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/03/01 14:39 MHDA- 2025/03/14 11:19 CRDT- 2025/02/28 19:29 PHST- 2024/11/10 00:00 [received] PHST- 2025/02/13 00:00 [revised] PHST- 2025/02/25 00:00 [accepted] PHST- 2025/03/14 11:19 [medline] PHST- 2025/03/01 14:39 [pubmed] PHST- 2025/02/28 19:29 [entrez] AID - S0195-6663(25)00086-8 [pii] AID - 10.1016/j.appet.2025.107933 [doi] PST - ppublish SO - Appetite. 2025 Apr 1;208:107933. doi: 10.1016/j.appet.2025.107933. Epub 2025 Feb 26. PMID- 40019763 OWN - NLM STAT- MEDLINE DCOM- 20250510 LR - 20250730 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 8 IP - 2 DP - 2025 Feb 3 TI - A Measure of Nutrition Security Using the National Health and Nutrition Examination Survey Dataset. PG - e2462130 LID - 10.1001/jamanetworkopen.2024.62130 [doi] LID - e2462130 AB - IMPORTANCE: Accurate and practical measures of nutrition security are needed to assess and monitor its prevalence and to identify its associated risk factors in the US. OBJECTIVE: To propose a nutrition security measure derived from combining self-assessed food security and diet quality indicators available in the National Health and Nutrition Examination Survey (NHANES) and to assess the prevalence and associated sociodemographic and health factors of nutrition security. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study used data from 6 cycles of NHANES, which collects data on general health status and behaviors, dietary intake, physiological measurements, and sociodemographic characteristics, conducted from 2007 to 2018. All participants were adults aged 20 years or older. Statistical analysis was performed between October 2023 and April 2024. EXPOSURES: Sociodemographic and health characteristics, including age, sex, race and ethnicity, marital status, household size, presence of children in the household, educational level, poverty to income ratio (PIR), Supplemental Nutrition Assistance Program (SNAP) participation, weight status, chronic conditions, and health insurance coverage. MAIN OUTCOMES AND MEASURES: A nutrition security measure was derived from combining self-assessed food security, measured using the US Department of Agriculture Household Food Security Survey Module, and self-rated diet quality indicators. Four nutrition security status categories were created from dichotomized food security and diet quality measures: food secure with high diet quality (FSHD), food secure with low diet quality (FSLD), food insecure with high diet quality (FIHD), and food insecure with low diet quality (FILD). Only respondents classified as FSHD were considered to be nutrition secure. RESULTS: The unweighted analytic sample included 28 898 NHANES participants. The weighted mean [SD] age of participants was 47.3 [14.5] years; 51.9% (weighted) of the sample was female; 11.1% identified as Black, 13.6% as Hispanic, and 67.4% as White individuals; and 35.6% of those surveyed were classified by the proposed measure as nutrition insecure (ie, FSLD, FIHD, or FILD). Of these participants, 20.2% (95% CI, 19.4%-21.0%) were categorized as being nutrition insecure due to FSLD, 8.4% (95% CI, 7.8%-9.1%) due to FIHD, and 7.0% (95% CI, 6.4%-7.6%) due to FILD. The remaining 64.4% (95% CI, 63.2%-65.7%) were classified as FSHD (ie, nutrition secure). Younger age (20-44 years: average marginal effect [AME], -0.193; 95% CI, -0.217 to -0.168), low income (PIR <1.30: AME, -0.111; 95% CI, -0.136 to -0.085), lower educational level ( 2), too much beard and/or soft tissue under the chin. Anthropometric measurements were taken with a modified digital vernier caliper. Mandibular cephalometric measurements were taken with the QuickCeph 2000 software on digital lateral cephalometric x-rays. All anthropometric and cephalometric measurements were taken by one operator. Based on the mandibular cephalometric measurements with the highest correlation, a mathematical model was proposed to predict the VDO [VDO' = (XAEO-STF)*0.3 + (R3R4 dist.)0.5 + (Go-Ar dist.)- 0.3 + (Ar-Po Mand.Depth.)*0.4 - 8], whose predictive capacity will be tested. RESULTS: The three cephalometric measurements with highest correlation with VDO were selected. The resulting predictive model correlated significantly with actual VDO (r= 0.77), in addition to having significant correlation values according to the Bjork-Jarabak facial biotypes. CONCLUSIONS: The proposed mathematical model demonstrated a strong correlation with the Vertical Dimension of Occlusion. It is a reliable method, uninfluenced by the patient's sex or biotype, and is useful for restoring the VDO within a physiological range close to its original state. CI - Copyright(c) 2024 Sociedad Argentina de Investigacion Odontologica. FAU - Garate-Silva, Omar E AU - Garate-Silva OE AD - Facultad de Odontologia, Universidad de Chile, omarenrique.gs@me.com. LA - eng PT - Journal Article PL - Argentina TA - Acta Odontol Latinoam JT - Acta odontologica latinoamericana : AOL JID - 8610218 SB - IM MH - Humans MH - *Cephalometry/methods MH - *Mandible/anatomy & histology MH - Adolescent MH - Adult MH - Young Adult MH - Male MH - *Vertical Dimension MH - Female MH - *Dental Occlusion PMC - PMC12331026 OTO - NOTNLM OT - cephalometry OT - mandibular size OT - modified Knebelman technique OT - predictive model OT - vertical dimension of occlusion COIS- The authors declare no potential conflicts of interest regarding the research, authorship, and/or publication of this article. EDAT- 2025/02/27 18:20 MHDA- 2025/02/27 18:21 PMCR- 2024/12/31 CRDT- 2025/02/27 15:54 PHST- 2024/04/01 00:00 [received] PHST- 2024/12/01 00:00 [accepted] PHST- 2025/02/27 18:21 [medline] PHST- 2025/02/27 18:20 [pubmed] PHST- 2025/02/27 15:54 [entrez] PHST- 2024/12/31 00:00 [pmc-release] AID - 00006 [pii] AID - 10.54589/aol.37/3/237 [doi] PST - ppublish SO - Acta Odontol Latinoam. 2024 Dec;37(3):237-245. doi: 10.54589/aol.37/3/237. PMID- 40014004 OWN - NLM STAT- MEDLINE DCOM- 20250510 LR - 20260715 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 9 DP - 2025 Feb 27 TI - Capturing Everyday Parental Feeding Practices and Eating Behaviors of 3- to 5-Year-Old Children With Avid Eating Behavior: Ecological Momentary Assessment Feasibility and Acceptability Study. PG - e66807 LID - 10.2196/66807 [doi] LID - e66807 AB - BACKGROUND: The wide use of smartphones offers large-scale opportunities for real-time data collection methods such as ecological momentary assessment (EMA) to assess how fluctuations in contextual and psychosocial factors influence parents' feeding practices and feeding goals, particularly when feeding children with high food approaches. OBJECTIVE: The main objectives of this study were to (1) assess parents/caregivers' compliance with EMA procedures administered through a smartphone app and (2) estimate the criterion validity of the EMA to capture children's eating occasions and parents' feeding practices. Participant adherence, technological challenges, and data quality were used to provide an overview of the real-time dynamics of parental mood, feeding goals, and contextual factors during eating occasions. METHODS: Parents in the United Kingdom with a child aged 3 to 5 years who exhibit avid eating behavior were invited to participate in a 10-day EMA study using a smartphone app. Of the 312 invited participants, 122 (39%) parents initiated the EMA study, of which 118 (96.7%) completed the full EMA period and the follow-up feasibility and acceptability survey. RESULTS: Of those parents who completed the EMA study, 104 (87.4%) parents provided at least 7 "full" days of data (2 signal surveys and 1 event survey), despite 51 parents (43.2%) experiencing technical difficulties. The parents received notifications for morning surveys (69.9% response rate), 3 daily mood surveys (78.7% response rate), and an end-of-day survey (84.6% response rate) on each of the 10 days. Over the EMA period, a total of 2524 child eating/food request surveys were self-initiated by the participants on their smartphones, an average of 2.1 times per day per parent (SD 0.18; min=1.7, max=2.3). The majority of parents felt that the surveys made them more aware of their feelings (105/118, 89%) and activities (93/118, 79%). The frequency of daily food requests estimated by parents at baseline was significantly correlated with the frequency of food requests reported daily during the EMA period (r=0.483, P<.001). However, the number of daily food requests per day estimated at baseline (mean 4.5, SD 1.5) was significantly higher than the number of food requests reported per day during the EMA period (mean 3.7, SD 1.1), (t116=18.8, P<.001). CONCLUSIONS: This paper demonstrates the feasibility of employing EMA to investigate the intricate interplay between parental mood, feeding goals, contextual factors, and feeding practices with children exhibiting an avid eating behavior profile. However, the use of EMA needs to be carefully developed and tested with parents' involvement to ensure successful data collection. CI - (c) Abigail Pickard, Katie Edwards, Claire Farrow, Emma Haycraft, Jacqueline Blissett. Originally published in JMIR Formative Research (https://formative.jmir.org). FAU - Pickard, Abigail AU - Pickard A AUID- ORCID: 0000-0002-1708-500X AD - School of Psychology and Institute of Health and Neurodevelopment, Aston University, Birmingham, United Kingdom. AD - Department of Clinical Psychology, School of Health in Social Science, University of Edinburgh, Wilkie Building, Edinburgh, United Kingdom, 44 1316501000. FAU - Edwards, Katie AU - Edwards K AUID- ORCID: 0000-0003-1076-8382 AD - School of Psychology and Institute of Health and Neurodevelopment, Aston University, Birmingham, United Kingdom. AD - School of Psychology, University of Birmingham, Birmingham, United Kingdom. FAU - Farrow, Claire AU - Farrow C AUID- ORCID: 0000-0003-3745-6610 AD - School of Psychology and Institute of Health and Neurodevelopment, Aston University, Birmingham, United Kingdom. FAU - Haycraft, Emma AU - Haycraft E AUID- ORCID: 0000-0002-7359-1759 AD - School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom. FAU - Blissett, Jacqueline AU - Blissett J AUID- ORCID: 0000-0002-0275-6413 AD - School of Psychology and Institute of Health and Neurodevelopment, Aston University, Birmingham, United Kingdom. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250227 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - Child, Preschool MH - *Ecological Momentary Assessment MH - Female MH - Male MH - *Parents/psychology MH - *Feeding Behavior/psychology MH - Feasibility Studies MH - United Kingdom MH - Mobile Applications MH - Adult MH - Smartphone MH - Parent-Child Relations MH - Child Behavior/psychology MH - Surveys and Questionnaires PMC - PMC11884305 OTO - NOTNLM OT - child OT - application OT - child eating OT - digital OT - digital health OT - digital intervention OT - digital technology OT - ecological momentary assessment OT - mHealth OT - mobile app OT - mobile health OT - paediatric OT - parent OT - parent feeding OT - pediatric OT - smartphone COIS- Conflicts of Interest: None declared. EDAT- 2025/02/27 12:27 MHDA- 2025/02/27 12:28 PMCR- 2025/02/27 CRDT- 2025/02/27 10:33 PHST- 2024/09/23 00:00 [received] PHST- 2025/01/07 00:00 [revised] PHST- 2025/01/07 00:00 [accepted] PHST- 2025/02/27 12:28 [medline] PHST- 2025/02/27 12:27 [pubmed] PHST- 2025/02/27 10:33 [entrez] PHST- 2025/02/27 00:00 [pmc-release] AID - v9i1e66807 [pii] AID - 66807 [pii] AID - 10.2196/66807 [doi] PST - epublish SO - JMIR Form Res. 2025 Feb 27;9:e66807. doi: 10.2196/66807. PMID- 40011618 OWN - NLM STAT- MEDLINE DCOM- 20250329 LR - 20250520 IS - 1476-5446 (Electronic) IS - 1462-0049 (Print) IS - 1462-0049 (Linking) VI - 26 IP - 1 DP - 2025 Mar TI - Can we rely on delaying the uptake of sugar consumption in the prevention of early childhood caries? PG - 36-37 LID - 10.1038/s41432-025-01125-8 [doi] AB - A COMMENTARY ON: Feldens C A, de Barros Coelho E M R, Vitolo M R, Rogrigues P H, Kramer P F, Peres K G Effectiveness of a sugar consumption prevention programme in the first year of life on the occurrence of early childhood caries: a multicentric randomized trial in Brazil. Caries Res 2024; https://doi.org/10.1159/000541028 . STUDY DESIGN: A multi-centre randomised controlled trial was carried out in Brazil. The intervention group received nutritional counselling based on dietary guidelines produced by UNICEF. The control group received standard dietary and maternal counselling provided by the hospital provider. Randomisation of participants was completed through a computer-based system with an investigator blinded to the recruitment process. Patients were followed up monthly using a combination of phone calls and home visits. SAMPLE: Pregnant women were recruited from four hospitals, across three state capitals, participating in the Baby Friendly Hospital Initiative. Mothers were to be at least 18 years of age, testing negative for HIV/HTLV1, and had an uncomplicated pregnancy. Their newborns had to have a gestational age of more than 37 weeks and weigh more than 2.5 kg. A newborn with increased hospital stays due to infection or neonatal conditions which affected breastfeeding were not included. Sample size calculation was undertaken. DATA ANALYSIS: Baseline data was collected. At 6- and 12-month intervals, a combination of validated questionnaires, including 24-hour recalls, and interviews were used to assess the diet. Oral health assessments were carried out by a blinded, trained and calibrated paediatric dentist. The primary outcome was a reduction in ECC. Effect measures (relative risk [RR]) were calculated to determine the effect of the intervention on not consuming sugar at 6 months and on the mean number of sugary items consumed at 12 months. RESULTS: Baseline demographic data were similar, with no significant differences noted, between the intervention and control groups. The probability of not consuming sugar in the first 6-months was 2.4 times less in the intervention group relative to the control group (p = 0.016). ECC was diagnosed in 17.4% of the whole sample; however, no significant difference was noted between groups at any time point (p = 0.281). CONCLUSIONS: Increased intervention to the mother in the first 6-months of life was effective at reducing the amount of sugar intake. However, this did not lead to a statistically significant reduction in ECC. CI - (c) 2025. The Author(s). FAU - O'Brien, Orion AU - O'Brien O AD - Newcastle University, School of Dental Sciences, Newcastle upon Tyne, UK. FAU - Taylor, Greig D AU - Taylor GD AUID- ORCID: 0000-0001-9369-917X AD - Newcastle University, School of Dental Sciences, Newcastle upon Tyne, UK. greig.taylor@newcastle.ac.uk. LA - eng PT - Journal Article DEP - 20250226 PL - England TA - Evid Based Dent JT - Evidence-based dentistry JID - 100883603 RN - 0 (Dietary Sugars) SB - IM MH - Adult MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Infant, Newborn MH - Pregnancy MH - Brazil MH - *Dental Caries/prevention & control MH - *Dietary Sugars/administration & dosage MH - Randomized Controlled Trials as Topic MH - Multicenter Studies as Topic PMC - PMC11953046 COIS- Competing interests: The authors declare no competing interests. EDAT- 2025/02/27 05:01 MHDA- 2025/03/29 16:15 PMCR- 2025/02/26 CRDT- 2025/02/26 23:32 PHST- 2025/01/24 00:00 [received] PHST- 2025/01/31 00:00 [accepted] PHST- 2025/03/29 16:15 [medline] PHST- 2025/02/27 05:01 [pubmed] PHST- 2025/02/26 23:32 [entrez] PHST- 2025/02/26 00:00 [pmc-release] AID - 10.1038/s41432-025-01125-8 [pii] AID - 1125 [pii] AID - 10.1038/s41432-025-01125-8 [doi] PST - ppublish SO - Evid Based Dent. 2025 Mar;26(1):36-37. doi: 10.1038/s41432-025-01125-8. Epub 2025 Feb 26. PMID- 40011414 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20261010 IS - 1932-2267 (Electronic) IS - 1932-2259 (Linking) VI - 20 IP - 4 DP - 2026 Aug TI - Applied theory of planned behavior to explore associated factor of physical activity level among Chinese childhood cancer survivors. PG - 1697-1709 LID - 10.1007/s11764-025-01768-7 [doi] AB - OBJECTIVE: Low physical activity (PA) levels are common among childhood cancer survivors (CCS) and have a serious negative impact on their physical recovery and long-term health. This study aimed to explore the factors that contribute to low levels of PA from the perspective of children themselves and how these factors affect their PA. METHODS: In this cross-sectional survey, CCS were recruited by purposive sampling from several children's medical centers nationwide. The online questionnaires, which involved three valid scales (the Godin Leisure-Time Exercise Questionnaire, Theory of Planned Behavior (TPB) construct, and Physical Activity Self-efficacy), were used for data collection from July 2021 to January 2023. The Wilcoxon rank-sum test, Chi-square or Fisher's exact test, and logistic regression analysis were used to analyze the factors associated with PA in CCS. The associations between CCS' PA level and cognitive variables (TPB construct and self-efficacy) were evaluated using path analysis. RESULTS: Among the 1350 eligible participants, ultimately 964 of them submitted valid questionnaires. According to the leisure time index (LSI) scores, 59.34% of Chinese CCS reached the recommendation level of moderate-vigorous physical activity (MVPA) (LSI >/= 24). Attending school, diagnosis, time since discharge, behavioral intention, and self-efficacy were associated with MVPA levels in CCS. Path analysis showed that intention and self-efficacy exerted a direct effect on CCS' PA, whereas the direct impact of perceived behavioral control on MVPA was not significant. The overall model fit indices of the TPB extended model incorporating self-efficacy showed the model fits the data well (RMSEA = 0.000, CFI = 1.000, NFI = 1.001, and TLI = 1.009). CONCLUSION: Compared to healthy populations, the level of MVPA participation among Chinese CCS was relatively lower. Improving self-efficacy is essential for increasing participation in CCS' physical activities. The extended TPB model with self-efficacy is appropriate for explaining MVPA participation in CCS. IMPLICATIONS FOR CANCER SURVIVORS: This study highlights the critical need to address low physical activity levels among childhood cancer survivors (CCS), as insufficient engagement in moderate-vigorous physical activity (MVPA) may hinder their recovery and longterm health outcomes. The findings underscore the pivotal role of self-efficacy in promoting MVPA participation, with both direct and indirect effects on activity behaviors. Interventions targeting CCS should prioritize strategies to enhance self-efficacy-such as goal-setting, skill-building, and psychosocial support-to foster sustained engagement in physical activity. Additionally, the validated extended theory of planned behavior (TPB) model provides a framework for designing tailored, survivor-centered programs that address behavioral, social, and environmental barriers. Clinicians and caregivers should adopt multidimensional approaches integrating self-efficacy enhancement, peer/community support, and accessible physical activity opportunities to mitigate long-term health risks and improve quality of life for CCS. CI - (c) 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Xu, Fengjiao AU - Xu F AD - Department of Social Medicine of School of Public Health and Department of Pharmacy of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, Zhejiang, China. AD - Department of Nursing, School of Medicine, Shaoxing University, Zhejiang, China. FAU - Weng, Yiqing AU - Weng Y AD - Department of Social Medicine of School of Public Health and Department of Pharmacy of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, Zhejiang, China. FAU - Lv, Danni AU - Lv D AD - Department of Surgical Oncology, Children'S Hospital Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, China. AD - Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Zheng, Hui AU - Zheng H AD - Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. FAU - Xiong, Jieni AU - Xiong J AD - Department of Surgical Oncology, Children'S Hospital Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, China. AD - Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Zhang, Li AU - Zhang L AD - Department of Social Medicine of School of Public Health and Department of Pharmacy of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, Zhejiang, China. FAU - Lu, Feng AU - Lu F AD - Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Guo, Xia AU - Guo X AD - Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Cai, Weisong AU - Cai W AD - Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Wang, Qian AU - Wang Q AD - Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Li, Yang AU - Li Y AD - Pediatric Hematology and Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. FAU - Zeng, Meiling AU - Zeng M AD - Department of Pediatric, The First Hospital of Chenzhou, Hunan, Chenzhou, China. FAU - Yuan, Xiuli AU - Yuan X AD - Department of Hematology and Oncology, Shenzhen Children'S Hospital, Shenzhen, Guangdong, China. FAU - Yi, Meng AU - Yi M AD - Department of Hematology and Oncology, Shenzhen Children'S Hospital, Shenzhen, Guangdong, China. FAU - Jin, Libin AU - Jin L AD - Department of Orthopedics, School of Medicine, The Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Mao, Junqing AU - Mao J AD - Department of Surgical Oncology, Children'S Hospital Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, China. AD - Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Xu, Xiaojun AU - Xu X AD - Division of Hematology/Oncology, Children'S Hospital of Zhejiang University School of Medicine, Hangzhou, China. FAU - Shen, Zhipeng AU - Shen Z AD - Department of Neurosurgery, The Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Zhang, Shouhua AU - Zhang S AD - Department of General Surgery, The Affiliated Children'S Hospital of Nanchang University, Nanchang, 330000, China. FAU - Li, Kehao AU - Li K AD - Department of General Surgery, The Affiliated Children'S Hospital of Nanchang University, Nanchang, 330000, China. FAU - Chen, Xin AU - Chen X AD - Department of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China. FAU - Gao, Qun AU - Gao Q AD - Department of General Surgery, Anhui Children'S Hospital, Hefei, Anhui, China. FAU - Lu, Xianying AU - Lu X AD - Department of General Surgery, Anhui Children'S Hospital, Hefei, Anhui, China. FAU - Fang, Tao AU - Fang T AD - Department of General Surgery, Anhui Children'S Hospital, Hefei, Anhui, China. FAU - Liu, Yunxia AU - Liu Y AD - Department of Oncology, The Third Hospital of Hangzhou, Affiliated Hangzhou Clinical College, Anhui Medical University, Hangzhou, China. FAU - Li, Linjie AU - Li L AD - Department of Surgical Oncology, Children'S Hospital Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, China. AD - Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Wang, Beijia AU - Wang B AD - Department of Social Medicine of School of Public Health and Department of Pharmacy of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, Zhejiang, China. FAU - Zhou, Rui AU - Zhou R AD - Department of Social Medicine of School of Public Health and Department of Pharmacy of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, Zhejiang, China. FAU - Gu, Renjun AU - Gu R AD - Department of Social Medicine of School of Public Health and Department of Pharmacy of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, Zhejiang, China. FAU - Yang, Mohan AU - Yang M AD - Department of Nursing, School of Medicine, Shaoxing University, Zhejiang, China. FAU - Zhang, Mengdie AU - Zhang M AD - Department of Social Medicine of School of Public Health and Department of Pharmacy of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, Zhejiang, China. FAU - Miao, Binghui AU - Miao B AD - Department of Social Medicine of School of Public Health and Department of Pharmacy of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, Zhejiang, China. FAU - Gao, Ju AU - Gao J AD - Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China. gaoju651220@126.com. FAU - Wang, Jinhu AU - Wang J AD - Department of Surgical Oncology, Children'S Hospital Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, China. wjh@zju.edu.cn. AD - Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China. wjh@zju.edu.cn. FAU - Wang, Hongmei AU - Wang H AD - Department of Social Medicine of School of Public Health and Department of Pharmacy of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, Zhejiang, China. rosa@zju.edu.cn. LA - eng PT - Journal Article DEP - 20250226 PL - United States TA - J Cancer Surviv JT - Journal of cancer survivorship : research and practice JID - 101307557 RN - Chinese people SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Cancer Survivors/psychology/statistics & numerical data MH - China MH - Cross-Sectional Studies MH - *Exercise/psychology/statistics & numerical data MH - Health Behavior MH - *Neoplasms/psychology/mortality MH - Self Efficacy MH - Surveys and Questionnaires MH - *Theory of Planned Behavior MH - East Asian People/psychology/statistics & numerical data OTO - NOTNLM OT - Cancer survivor OT - Children OT - Exercise OT - Physical activity OT - Self-efficacy OT - Theory of planned behavior COIS- Declarations. Ethics approval: This study complied with the principles of the Helsinki Declaration on human research. Consent for participation or signature confirmation was required for this study in order to ensure that every patient was willing to participate. No potentially identifiable human images or data are presented in this study. Consent to participate: All the participants' parents provided signed informed consent before the surveys were conducted. Competing interests: The authors declare no competing interests. EDAT- 2025/02/27 05:03 MHDA- 2026/07/16 16:06 CRDT- 2025/02/26 23:19 PHST- 2024/11/22 00:00 [received] PHST- 2025/02/12 00:00 [accepted] PHST- 2026/07/16 16:06 [medline] PHST- 2025/02/27 05:03 [pubmed] PHST- 2025/02/26 23:19 [entrez] AID - 10.1007/s11764-025-01768-7 [pii] AID - 10.1007/s11764-025-01768-7 [doi] PST - ppublish SO - J Cancer Surviv. 2026 Aug;20(4):1697-1709. doi: 10.1007/s11764-025-01768-7. Epub 2025 Feb 26. PMID- 40009599 OWN - NLM STAT- MEDLINE DCOM- 20250226 LR - 20261007 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 2 DP - 2025 TI - Comparison of two methods of measuring physical activity and its related components among middle age women: Pedometer versus self-report. PG - e0319288 LID - 10.1371/journal.pone.0319288 [doi] LID - e0319288 AB - INTRODUCTION: Physical activity is essential for health maintenance across various dimensions; however, sedentary behavior remains widespread in numerous societies. Notably, women often exhibit higher levels of sedentary behavior than men, potentially exacerbating complications related to motherhood. This study aims to assess and compare physical activity levels in middle-aged women (30-45) using self-reported measures and pedometers while exploring associated factors in the context of reproductive health. METHODS: This study analyzed secondary data from a randomized controlled trial involving 91 women aged 30-45 from Semnan University of Medical Sciences. Participants completed a validated 12-item questionnaire and wore Omron Style Pro-2 pedometers for one week to assess physical activity levels. Women were categorized as active or inactive based on self-reports and pedometer data. Statistical analyses were conducted using SPSS version 27. Participants provided informed consent, ensuring confidentiality throughout the study. RESULTS: The study involved 91 women with a mean age of 27.4 years, of whom 82.6% were married. Only 11.7% self-reported as "low active," while pedometer data revealed that 94.5% were inactive or had insufficient physical activity. A significant relationship was found between the number of children and physical activity levels, with women who had children being more active (p = 0.035). No correlation was observed between self-reported activity and pedometer measurements, indicating women often overestimate their physical activity levels. DISCUSSION: This study highlights the inaccuracies in self-reported physical activity assessments. Most women were found to be physically inactive, with the number of children influencing their activity levels. These findings underscore the need for interventions to increase women's physical activity. CONCLUSION: These findings bear important implications for health policy within communities. Further research involving larger sample sizes across various age and gender demographics is warranted to enhance our understanding of physical activity patterns and inform targeted interventions. CI - Copyright: (c) 2025 Ghaneapur et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Ghaneapur, Mohammadreza AU - Ghaneapur M AUID- ORCID: 0000-0002-3898-0003 AD - Department of Public Health, Damghan school of public Health, Semnan University of Medical Sciences, Semnan, Iran. FAU - Ezati Asar, Mohamad AU - Ezati Asar M AD - Department of Public Health, Damghan school of public Health, Semnan University of Medical Sciences, Semnan, Iran. AD - Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran. FAU - Belji Kangarlou, Marzieh AU - Belji Kangarlou M AD - Department of Occupational Health and Safety, Faculty of Medical Sciences, Tehran University of Medical Science, Tehran, Iran. AD - Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran. FAU - Saleh, Elahe AU - Saleh E AUID- ORCID: 0000-0002-3898-0003 AD - Department of Public Health, Damghan school of public Health, Semnan University of Medical Sciences, Semnan, Iran. AD - Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20250226 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - *Self Report MH - Adult MH - *Exercise/physiology MH - Middle Aged MH - Sedentary Behavior MH - Surveys and Questionnaires MH - Walking PMC - PMC11864511 COIS- The authors have declared that no competing interests exist. EDAT- 2025/02/26 18:17 MHDA- 2025/02/26 18:18 PMCR- 2025/02/26 CRDT- 2025/02/26 13:42 PHST- 2024/07/15 00:00 [received] PHST- 2025/01/29 00:00 [accepted] PHST- 2025/02/26 18:18 [medline] PHST- 2025/02/26 18:17 [pubmed] PHST- 2025/02/26 13:42 [entrez] PHST- 2025/02/26 00:00 [pmc-release] AID - PONE-D-24-26896 [pii] AID - 10.1371/journal.pone.0319288 [doi] PST - epublish SO - PLoS One. 2025 Feb 26;20(2):e0319288. doi: 10.1371/journal.pone.0319288. eCollection 2025. PMID- 40009162 OWN - NLM STAT- MEDLINE DCOM- 20250510 LR - 20260716 IS - 1432-0711 (Electronic) IS - 0932-0067 (Print) IS - 0932-0067 (Linking) VI - 311 IP - 3 DP - 2025 Mar TI - An elevated triglyceride-glucose index in the first-trimester predicts adverse pregnancy outcomes: a retrospective cohort study. PG - 915-927 LID - 10.1007/s00404-025-07973-0 [doi] AB - BACKGROUND: The relationship of the first-trimester triglyceride-glucose (TyG) index with GDM (gestational diabetes mellitus) and other adverse pregnancy outcomes has yet to be fully understood. This study aims to investigate the relationship between the first-trimester TyG index and the risk of adverse pregnancy outcomes in pregnant women. METHODS: The data for the retrospective cohort study were derived from the Maternal and Child Health Hospital of Longgang District, Shenzhen, China. To calculate the TyG index, health indicators were measured in the early pregnancy period (<14 gestational weeks), including triglycerides and fasting blood glucose levels in pregnant women. Multivariable regression analysis and subgroup analysis were used to ascertain the independent association between the TyG index and the possibility of adverse pregnancy outcomes. Interaction analysis was performed to assess the potential heterogeneity of associations among subgroups. Nonlinear associations and the predictive value of the TyG index were explored using restricted cubic splines and receiver operating characteristic (ROC) curves. The discrimination and accuracy of the fully adjusted model were evaluated using calibration curves, Brier scores, and decision curve analysis (DCA). Mediation analysis was conducted to assess the impact of GDM (gestational diabetes mellitus) and PE (preeclampsia) as intermediaries on the risk of Preterm delivery. RESULTS: The study included a cohort of 11,942 pregnant women, with an average TyG index of 8.36 +/- 0.41. Logistic regression analysis showed that after adjusting for covariates, for each 1-unit increase in the TyG index, the risk of GDM increased by 2.21-fold, and this result was significantly different across all quartiles. Compared to the lowest quartile group, the highest TyG index group had the highest risk of PE (OR: 2.89; 95% CI 1.39 ~ 6.50), GH (gestational hypertension) (OR: 1.47; 95% CI 1.07 ~ 2.02), and Preterm delivery (OR: 1.75; 95% CI 1.21 ~ 2.56).The analysis of data stratification and interaction confirmed the validity of our study results. However, the analysis found no statistically significant association between the TyG index and low birth weight and macrosomia. GDM and PE were identified as partial mediating factors between TyG and the risk of preterm delivery, with variance contributions of 7.23% and 20.33%. The TyG index demonstrated the highest area under the curve (AUC) values in the ROC curves for GDM, PE, GH, and preterm delivery, with values of 0.61, 0.67, 0.58, and 0.56, respectively. The combination of the TyG index, maternal age, and pre-pregnancy body mass index predicted outcomes better than the TyG index alone (p < 0.01).After adjustment for confounders, the model showed good accuracy and net benefit in predicting adverse pregnancy outcomes, as supported by calibration curves, Brier scores, and decision curve analysis. CONCLUSION: An elevated first-trimester TyG index correlates with a heightened risk of GDM, PE, GH and Preterm delivery.The TyG index presents a promising tool for more effectively identifying populations at early risk for adverse pregnancy outcomes. CI - (c) 2025. The Author(s). FAU - Song, Songhong AU - Song S AD - Department of Preventive Medicine, Shantou University Medical College, Shantou, China. AD - Institute of Clinical Electrocardiography, First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong, China. AD - Longgang Maternity and Child Institute of Shantou University Medical College, Shenzhen, 518172, Guangdong, China. FAU - Luo, Qi AU - Luo Q AD - School of Basic Medical Sciences, Jiamusi University, Jiamusi, 154007, China. FAU - Zhong, Xinyang AU - Zhong X AD - Department of Preventive Medicine, Shantou University Medical College, Shantou, China. AD - Longgang Maternity and Child Institute of Shantou University Medical College, Shenzhen, 518172, Guangdong, China. FAU - Huang, Man AU - Huang M AD - School of Pharmacy, Zunyi Medical University, Guizhou, 563006, China. FAU - Zhu, Jinxiu AU - Zhu J AD - Institute of Clinical Electrocardiography, First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong, China. doczjx7511@163.com. AD - Longgang Maternity and Child Institute of Shantou University Medical College, Shenzhen, 518172, Guangdong, China. doczjx7511@163.com. LA - eng GR - 2023A1515011969/Provincial Natural Science Foundation of Guangdong/ GR - STKJ2021052/Guangdong Province Science and Technology Special Fund Project/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250226 PL - Germany TA - Arch Gynecol Obstet JT - Archives of gynecology and obstetrics JID - 8710213 RN - 0 (Blood Glucose) RN - 0 (Triglycerides) SB - IM MH - Humans MH - Female MH - Pregnancy MH - Retrospective Studies MH - Adult MH - *Diabetes, Gestational/blood/epidemiology MH - *Pregnancy Trimester, First/blood MH - *Blood Glucose/analysis MH - *Triglycerides/blood MH - Pregnancy Outcome MH - China/epidemiology MH - Premature Birth/epidemiology/blood MH - Pre-Eclampsia/blood/epidemiology MH - Predictive Value of Tests MH - ROC Curve PMC - PMC11920334 OTO - NOTNLM OT - Adverse pregnancy outcomes OT - First-trimester OT - Maternal health OT - Pregnancy assessment OT - Triglyceride-glucose index COIS- Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: This study was conducted by the ethical principles of the Helsinki Declaration and was approved by the Ethics Committee of Longgang District Maternal and Child Health Hospital, Shenzhen City (LGFYKYXMLL-2024-88). Consent for publication: All authors have read and agreed to the published version of the manuscript. EDAT- 2025/02/26 12:24 MHDA- 2025/03/18 18:22 PMCR- 2025/02/26 CRDT- 2025/02/26 11:13 PHST- 2024/11/20 00:00 [received] PHST- 2025/01/25 00:00 [accepted] PHST- 2025/03/18 18:22 [medline] PHST- 2025/02/26 12:24 [pubmed] PHST- 2025/02/26 11:13 [entrez] PHST- 2025/02/26 00:00 [pmc-release] AID - 10.1007/s00404-025-07973-0 [pii] AID - 7973 [pii] AID - 10.1007/s00404-025-07973-0 [doi] PST - ppublish SO - Arch Gynecol Obstet. 2025 Mar;311(3):915-927. doi: 10.1007/s00404-025-07973-0. Epub 2025 Feb 26. PMID- 40008659 OWN - NLM STAT- MEDLINE DCOM- 20250421 LR - 20250421 IS - 1699-5198 (Electronic) IS - 0212-1611 (Linking) VI - 42 IP - 2 DP - 2025 Apr 21 TI - The empirical pattern of dietary inflammation is unrelated to nutritional status in college students. PG - 341-348 LID - 10.20960/nh.05239 [doi] AB - Introduction: food contains both inflammatory and anti-inflammatory components. The higher the concentration of inflammatory components, the greater the likelihood of developing obesity and other chronic conditions linked to low-grade chronic inflammation. Consequently, various indices have been developed to quantify dietary inflammation, such as the Empirical Dietary Inflammatory Pattern (EDIP-SP), which has been validated in Brazil. This study aimed to examine the potential association between EDIP-SP and the nutritional status of college students. Methodology: the study involved 97 undergraduate nutrition students from Fortaleza, Ceara, in Northeast Brazil. Participants completed a food frequency questionnaire to assess their intake of EDIP-SP components, including processed meats, vegetables, fruits, rice, and beans. Anthropometric measurements (weight, height, and waist circumference) were taken to calculate body mass index (BMI) and to categorize nutritional status and abdominal adiposity. Results: the diet consumed by the participants was primarily anti-inflammatory, with a mean score of -1.57 +/- 0.69. Most participants were not classified as overweight (59.79 %) and did not exhibit abdominal adiposity (91.75 %). No significant association was observed between EDIP-SP scores and BMI (r = -0.11; p = 0.297) or waist circumference (r = -0.07; p = 0.489). However, a weak but direct association was found between the inflammatory score of processed meat intake and abdominal adiposity in female participants (r = 0.27; p = 0.019). Conclusion: the Empirical Dietary Inflammation Pattern (EDIP-SP) does not appear to significantly influence the nutritional status of students. Nevertheless, the inflammatory impact of processed meat intake may contribute to excess abdominal adiposity, particularly among women. FAU - Araujo, Noenia Alves de AU - Araujo NA AD - Universidade Estadual do Ceara. FAU - Sampaio, Helena Alves de Carvalho AU - Sampaio HAC AD - Universidade Estadual do Ceara. FAU - Carioca, Antonio Augusto Ferreira AU - Carioca AAF AD - Universidade de Fortaleza. FAU - Silva, Bruna Yhang da Costa AU - Silva BYDC AD - Instituto Federal do Ceara. FAU - Barros, Anael Queiros Silva AU - Barros AQS AD - Universidade Estadual do Ceara. FAU - Silva, Ruth Pereira Costa da AU - Silva RPCD AD - Universidade Estadual do Ceara. FAU - Neto, Carlos Cardoso AU - Neto CC AD - Universidade Estadual do Ceara. FAU - Leal, Antonio Lucas Fernandes AU - Leal ALF AD - Universidade Estadual do Ceara. LA - eng PT - Journal Article TT - El patron empirico de inflamacion dietetica no esta relacionado con el estado nutricional en estudiantes universitarios. PL - Spain TA - Nutr Hosp JT - Nutricion hospitalaria JID - 9100365 SB - IM MH - Humans MH - Female MH - *Nutritional Status MH - Male MH - Students MH - *Inflammation/epidemiology/etiology MH - Young Adult MH - *Diet MH - Universities MH - Brazil/epidemiology MH - Body Mass Index MH - Adult MH - Adolescent MH - Waist Circumference MH - Cross-Sectional Studies OTO - NOTNLM OT - Dieta. Inflamacion. Estados nutricionales. Ingesta de alimentos. Estudiantes de Ciencias de la Salud. EDAT- 2025/02/26 12:24 MHDA- 2025/04/21 12:29 CRDT- 2025/02/26 07:23 PHST- 2025/04/21 12:29 [medline] PHST- 2025/02/26 12:24 [pubmed] PHST- 2025/02/26 07:23 [entrez] AID - 10.20960/nh.05239 [doi] PST - ppublish SO - Nutr Hosp. 2025 Apr 21;42(2):341-348. doi: 10.20960/nh.05239. PMID- 40005313 OWN - NLM STAT- MEDLINE DCOM- 20250510 LR - 20250510 IS - 1648-9144 (Electronic) IS - 1010-660X (Print) IS - 1010-660X (Linking) VI - 61 IP - 2 DP - 2025 Jan 23 TI - Determinants of Acute Otitis Media in Children: A Case-Control Study in West Java, Indonesia. LID - 10.3390/medicina61020197 [doi] LID - 197 AB - Background and Objectives: Acute Otitis Media (AOM) is a leading cause of morbidity in children, characterized by fever, otalgia, and hearing loss. If untreated, AOM may progress to chronic complications requiring surgical management. Globally, factors such as allergies, environmental tobacco smoke, and nutritional deficiencies are well-established risk factors, but in Indonesia, particularly rural areas like Bandung Regency, limited awareness and data exacerbate the burden of disease. Smoking prevalence and low immunization rates further increase risks for AOM. Materials and Methods: This case-control study, conducted between September 2019 and February 2020 in Bandung Regency, evaluated risk factors for AOM in children aged 24-59 months. Data were collected through structured questionnaires, anthropometric assessments, and ENT examinations. A total of 168 AOM-positive and 367 AOM-negative children were recruited from primary healthcare facilities. Results: Multivariable analysis identified significant associations with AOM: allergic rhinitis (AOR 1.92), cigarette smoke exposure (AOR 1.79), stunted growth (AOR 1.48), and incomplete basic immunizations (AOR 1.77). These findings highlight the importance of addressing modifiable factors such as nutrition and immunization to reduce AOM incidence. Conclusions: The rhinitis allergy and exposure to cigarette smoke are among the well-established risk factors that our results validate. Additional research is necessary to validate if our findings involving two modifiable risk factors, stunted children and insufficient basic vaccination, may increase the risk of AOM. FAU - Dermawan, Arif AU - Dermawan A AUID- ORCID: 0000-0002-3250-3994 AD - Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Padjadjaran, Kota Bandung 40161, Indonesia. FAU - Ropii, Bejo AU - Ropii B AUID- ORCID: 0000-0001-7985-900X AD - Preanger Institute for Biomedical Engineering, Science, and Technology, Depok 16424, Indonesia. FAU - Lasminingrum, Lina AU - Lasminingrum L AUID- ORCID: 0000-0001-9335-0074 AD - Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Padjadjaran, Kota Bandung 40161, Indonesia. FAU - Hasansulama, Wijana AU - Hasansulama W AUID- ORCID: 0000-0002-3196-3067 AD - Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Padjadjaran, Kota Bandung 40161, Indonesia. FAU - Setiabudiawan, Budi AU - Setiabudiawan B AUID- ORCID: 0000-0002-4842-2451 AD - Department of Child Health, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Kota Bandung 40161, Indonesia. AD - Faculty of Medicine, President University, Cikarang, Bekasi 17550, Indonesia. LA - eng PT - Journal Article DEP - 20250123 PL - Switzerland TA - Medicina (Kaunas) JT - Medicina (Kaunas, Lithuania) JID - 9425208 SB - IM MH - Humans MH - Indonesia/epidemiology MH - *Otitis Media/epidemiology/etiology MH - Case-Control Studies MH - Female MH - Male MH - Child, Preschool MH - Infant MH - Risk Factors MH - Surveys and Questionnaires MH - Acute Disease PMC - PMC11857338 OTO - NOTNLM OT - acute otitis media OT - allergic rhinitis OT - immunization OT - nutrition OT - pediatrics OT - smoking COIS- The authors confirm that there are no conflicts of interest related to the preparation of this study. EDAT- 2025/02/26 06:27 MHDA- 2025/02/26 06:28 PMCR- 2025/01/23 CRDT- 2025/02/26 01:22 PHST- 2024/12/09 00:00 [received] PHST- 2025/01/09 00:00 [revised] PHST- 2025/01/21 00:00 [accepted] PHST- 2025/02/26 06:28 [medline] PHST- 2025/02/26 06:27 [pubmed] PHST- 2025/02/26 01:22 [entrez] PHST- 2025/01/23 00:00 [pmc-release] AID - medicina61020197 [pii] AID - medicina-61-00197 [pii] AID - 10.3390/medicina61020197 [doi] PST - epublish SO - Medicina (Kaunas). 2025 Jan 23;61(2):197. doi: 10.3390/medicina61020197. PMID- 40005010 OWN - NLM STAT- MEDLINE DCOM- 20250509 LR - 20250509 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 4 DP - 2025 Feb 14 TI - The Effect of Anxiety and Nutritional Habits on the Body Distortion of Athletes. LID - 10.3390/nu17040682 [doi] LID - 682 AB - Background: Anxiety disorders have been rising globally, particularly among adolescents and women. However, the relationship between diet, psychological traits, and anxiety levels in athletes remains underexplored. Objectives: This study aimed to analyze the nutritional and psychological differences between athletes with varying anxiety levels, hypothesizing that higher anxiety correlates with unhealthier dietary habits, greater body distortion, and less adaptive psychological profiles. Methods: A total of 58 athletes (23 women, 35 men), aged 18 to 45 years (mean age = 30.2 years), participated in this cross-sectional study. Data were collected using validated online questionnaires, including the Big Five Inventory, Spielberger State-Trait Anxiety Inventory (STAI), Acceptance and Action Questionnaire-II (AAQ-II), UCLA Loneliness Scale, and Eating Disorder Inventory (EDI), as well as surveys assessing nutritional habits and physical activity levels. Statistical analyses were conducted using SPSS (v24.0), with independent t-tests to compare differences between higher and lower anxiety groups (p < 0.05). Results: It has beenindicated that higher anxiety was associated with greater neuroticism, lower psychological flexibility, and higher eating disorder symptomatology, while better sleep quality and psychological profiles correlated with lower anxiety levels. Additionally, athletes who cooked their own meals exhibited higher anxiety, whereas greater water intake and whole grain consumption were linked to lower anxiety. More frequent and intense training, particularly weight training, was also associated with reduced anxiety. Conclusion: This study concludes that anxiety in athletes is influenced by multiple lifestyle factors, including sleep quality, dietary habits, psychological traits, and exercise patterns. These findings emphasize the need for holistic approaches integrating nutrition, psychological interventions, and structured physical training to manage anxiety in athletes. FAU - Ramirez-Goerke, Maria Isabel AU - Ramirez-Goerke MI AD - Department of Pharmacy and Nutrition, Faculty of Health Sciences, Universidad Europea de Madrid, Villaviciosa de Odon, 28670 Madrid, Spain. FAU - Tornero-Aguilera, Jose Francisco AU - Tornero-Aguilera JF AUID- ORCID: 0000-0002-0747-8133 AD - KOS Generating Health, 45007 Toledo, Spain. FAU - Martin-Rodriguez, Alexandra AU - Martin-Rodriguez A AUID- ORCID: 0000-0002-0087-4379 AD - Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, Villaviciosa de Odon, 28670 Madrid, Spain. AD - Faculty of Applied Social Sciences and Communications, International Business University (UNIE), 28015 Madrid, Spain. FAU - Clemente-Suarez, Vicente Javier AU - Clemente-Suarez VJ AUID- ORCID: 0000-0002-2397-2801 AD - Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, Villaviciosa de Odon, 28670 Madrid, Spain. AD - Grupo de Investigacion en Cultura, Educacion y Sociedad, Universidad de la Costa, Barranquilla 080002, Colombia; . LA - eng PT - Journal Article DEP - 20250214 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Male MH - Adult MH - *Athletes/psychology MH - Cross-Sectional Studies MH - *Anxiety/psychology MH - Young Adult MH - *Feeding Behavior/psychology MH - Middle Aged MH - Adolescent MH - Surveys and Questionnaires MH - *Body Image/psychology MH - Exercise/psychology MH - Feeding and Eating Disorders/psychology MH - Diet/psychology PMC - PMC11858329 OTO - NOTNLM OT - anxiety OT - athletes OT - body composition OT - body distorsion OT - nutritional habits COIS- The authors declare no conflict of interest. EDAT- 2025/02/26 06:28 MHDA- 2025/02/26 06:29 PMCR- 2025/02/14 CRDT- 2025/02/26 01:20 PHST- 2025/01/30 00:00 [received] PHST- 2025/02/10 00:00 [revised] PHST- 2025/02/11 00:00 [accepted] PHST- 2025/02/26 06:29 [medline] PHST- 2025/02/26 06:28 [pubmed] PHST- 2025/02/26 01:20 [entrez] PHST- 2025/02/14 00:00 [pmc-release] AID - nu17040682 [pii] AID - nutrients-17-00682 [pii] AID - 10.3390/nu17040682 [doi] PST - epublish SO - Nutrients. 2025 Feb 14;17(4):682. doi: 10.3390/nu17040682. PMID- 40004993 OWN - NLM STAT- MEDLINE DCOM- 20250510 LR - 20250512 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 4 DP - 2025 Feb 13 TI - The Associations of Vitamin D Status and Lifestyle Behaviors with General Obesity and Metabolically Unhealthy Obesity in Chinese Children and Adolescents. LID - 10.3390/nu17040666 [doi] LID - 666 AB - BACKGROUND: Vitamin D and lifestyle behaviors are closely related to children's health. However, current research on the combined influences of vitamin D and adherence to 24-Hour Movement Guidelines (24-HMG) on childhood obesity remains scarce. Our study aimed to examine individual and joint associations of vitamin D status and the number of recommendations for adhering to 24-HMG with obesity among Chinese children and adolescents. METHODS: In this cross-sectional study, a total of 4625 participants from Shenzhen, China, were recruited. Vitamin D status was classified into two categories: adequacy and inadequacy. The 24-HMG was obtained from a validated questionnaire, including moderate-to-vigorous physical activity, screen time, and sleep duration. General obesity and metabolically unhealthy obesity (MUO) were the outcomes of this study. The logistic regression model was performed to examine the associations between vitamin D status, the number of guidelines met, and obesity. RESULTS: Vitamin D inadequacy was associated with increased odds of general obesity and MUO, with adjusted odds ratios (95% CIs) of 1.551 (1.080-2.226) and 2.205 (1.319-3.686). Meeting 2-3 recommendations of 24-HMG was associated with decreased odds of general obesity, with adjusted odds ratios (95% CIs) of 0.777 (0.626-0.965). Compared with the vitamin D adequacy/meeting 2-3 guidelines group, the vitamin D inadequacy/meeting 0-1 guideline group was positively related to general obesity (adjusted odd ratio, 1.826 [95% CI: 1.167-2.857]) and MUO (2.160, 1.175-3.972). In addition, the population-attributable fractions of vitamin D inadequacy or/and meeting 0-1 guideline were 28.4% (95% CI: 2.5-54.4%) for general obesity and 42.3% (95% CI: 11.5-73.1%) for MUO. CONCLUSIONS: Our findings displayed that the combined associations of vitamin D inadequacy and meeting 0-1 recommendations of 24-HMG were linked to high odds of general obesity and MUO, respectively. Understanding these relationships could provide a theoretical basis for effective preventive strategies and interventions for childhood obesity. FAU - Liu, Fangqu AU - Liu F AD - Shenzhen Center for Chronic Disease Control, Shenzhen 518020, China. AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Li, Yan AU - Li Y AD - Shenzhen Center for Chronic Disease Control, Shenzhen 518020, China. FAU - Liang, Chanhua AU - Liang C AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Kong, Bingxuan AU - Kong B AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Zhang, Qian AU - Zhang Q AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Yin, Xingzhu AU - Yin X AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Wu, Bangfu AU - Wu B AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Xiong, Jingfan AU - Xiong J AD - Shenzhen Center for Chronic Disease Control, Shenzhen 518020, China. FAU - Yao, Ping AU - Yao P AUID- ORCID: 0000-0002-0192-9546 AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Tang, Yuhan AU - Tang Y AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. FAU - Li, Yanyan AU - Li Y AUID- ORCID: 0000-0001-6667-9341 AD - Shenzhen Center for Chronic Disease Control, Shenzhen 518020, China. LA - eng GR - A2024150/Medical Science and Technology Foundation of Guangdong/ GR - SZSM202311020/Sanming Project of Medicine in Shenzhen/ GR - JCYJ20230807120900001/Shenzhen Science and Technology Program/ GR - SZXK065/Shenzhen Medical Key Discipline Construction Fund/ PT - Journal Article DEP - 20250213 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 1406-16-2 (Vitamin D) RN - Chinese people SB - IM MH - Humans MH - Child MH - Male MH - Adolescent MH - Female MH - Cross-Sectional Studies MH - *Pediatric Obesity/epidemiology/etiology MH - China/epidemiology MH - *Life Style MH - *Vitamin D/blood MH - *Vitamin D Deficiency/epidemiology/complications/blood MH - Exercise MH - *Nutritional Status MH - Surveys and Questionnaires MH - East Asian People PMC - PMC11858261 OTO - NOTNLM OT - 24-Hour Movement Guidelines OT - 25-hydroxyvitamin D OT - children OT - metabolically unhealthy obesity OT - obesity COIS- The authors declare they have no conflicts of interest. EDAT- 2025/02/26 06:29 MHDA- 2025/02/26 06:30 PMCR- 2025/02/13 CRDT- 2025/02/26 01:20 PHST- 2025/01/15 00:00 [received] PHST- 2025/02/03 00:00 [revised] PHST- 2025/02/05 00:00 [accepted] PHST- 2025/02/26 06:30 [medline] PHST- 2025/02/26 06:29 [pubmed] PHST- 2025/02/26 01:20 [entrez] PHST- 2025/02/13 00:00 [pmc-release] AID - nu17040666 [pii] AID - nutrients-17-00666 [pii] AID - 10.3390/nu17040666 [doi] PST - epublish SO - Nutrients. 2025 Feb 13;17(4):666. doi: 10.3390/nu17040666. PMID- 40003645 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250228 IS - 2075-1729 (Print) IS - 2075-1729 (Electronic) IS - 2075-1729 (Linking) VI - 15 IP - 2 DP - 2025 Feb 5 TI - A Decade of Progress in Ultrasound Assessments of Subcutaneous and Total Body Fat: A Scoping Review. LID - 10.3390/life15020236 [doi] LID - 236 AB - Body composition assessment by ultrasonography is a vivid research field. Ultrasound (US) can be used to quantify subcutaneous and visceral fat, to evaluate the quantity and quality of skeletal muscle, and to infer intracellular fat content. This scoping review aimed to summarize recent advancements in subcutaneous fat estimation using US and related applications. A systematic search was conducted on PubMed, MEDLINE, Scopus, Google Scholar, and Web of Science to identify original articles published in English between 1 January 2014 and 20 December 2024. A total of 1869 articles were screened based on their titles and abstracts, and 283 were retrieved for full-text evaluation. Our search and selection strategy resulted in 89 eligible documents. The literature discussed in this review suggests that US is a reliable and valid technique for measuring subcutaneous fat thickness at selected anatomic locations. Standardized measurement protocols enabled accurate subcutaneous adipose tissue (SAT) patterning in various populations (e.g., athletes, children, adults, and patients with anorexia nervosa). Further research is warranted to establish clinically relevant cutoff values. US-derived SAT thicknesses can also provide whole-body fat estimates of fat mass (FM), fat-free mass (FFM), and body fat percentage (%BF). To this end, prediction formulas were developed to ensure agreement with criterion measures given by laboratory techniques, or multicompartment models based on combinations thereof. The resulting assessments of global adiposity were reliable but inaccurate in certain populations (e.g., overweight and obese). Nevertheless, due to its high reliability, US might be used to track changes in body fat content during nutritional and/or lifestyle interventions. Future investigations will be needed to evaluate its accuracy in this respect and to improve the validity of whole-body fat estimation compared to multicompartment models. FAU - Neagu, Monica AU - Neagu M AUID- ORCID: 0000-0002-7845-7639 AD - Department of Functional Sciences, "Victor Babes" University of Medicine and Pharmacy of Timisoara, E. Murgu Sq, No. 2, 300041 Timisoara, Romania. AD - Center for Modeling Biological Systems and Data Analysis, "Victor Babes" University of Medicine and Pharmacy of Timisoara, E. Murgu Sq, No. 2, 300041 Timisoara, Romania. FAU - Neagu, Adrian AU - Neagu A AUID- ORCID: 0000-0003-3871-2188 AD - Department of Functional Sciences, "Victor Babes" University of Medicine and Pharmacy of Timisoara, E. Murgu Sq, No. 2, 300041 Timisoara, Romania. AD - Center for Modeling Biological Systems and Data Analysis, "Victor Babes" University of Medicine and Pharmacy of Timisoara, E. Murgu Sq, No. 2, 300041 Timisoara, Romania. AD - Department of Physics and Astronomy, University of Missouri, Columbia, MO 65211, USA. LA - eng PT - Journal Article PT - Review DEP - 20250205 PL - Switzerland TA - Life (Basel) JT - Life (Basel, Switzerland) JID - 101580444 PMC - PMC11856862 OTO - NOTNLM OT - adipose tissue OT - adiposity OT - anthropometry OT - body composition OT - body fat distribution OT - ultrasonography COIS- The authors declare no conflicts of interest. EDAT- 2025/02/26 06:27 MHDA- 2025/02/26 06:28 PMCR- 2025/02/05 CRDT- 2025/02/26 01:13 PHST- 2024/12/31 00:00 [received] PHST- 2025/01/30 00:00 [revised] PHST- 2025/02/02 00:00 [accepted] PHST- 2025/02/26 06:28 [medline] PHST- 2025/02/26 06:27 [pubmed] PHST- 2025/02/26 01:13 [entrez] PHST- 2025/02/05 00:00 [pmc-release] AID - life15020236 [pii] AID - life-15-00236 [pii] AID - 10.3390/life15020236 [doi] PST - epublish SO - Life (Basel). 2025 Feb 5;15(2):236. doi: 10.3390/life15020236. PMID- 40003328 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260924 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 2 DP - 2025 Feb 13 TI - The Factors Influencing Feeding Practices of Primary Caregivers of Preschoolers: A Theory-Based Cross-Sectional Study. LID - 10.3390/children12020226 [doi] LID - 226 AB - BACKGROUND/OBJECTIVES: Primary caregivers play a pivotal role in shaping children's dietary behaviors, which are critical in preventing childhood obesity. This study aimed to examine the extent to which demographic characteristics and caregiver factors, including dietary beliefs and intentions to provide a healthy diet, influence feeding practices among primary caregivers of preschool-aged children. METHODS: This study included a cross-sectional dataset comprising data collected from 146 primary caregivers of preschool-aged children (3-5 years). Participants were recruited using snowball and convenience sampling from Facebook and community settings in Cincinnati, Ohio. Feeding practices were assessed using the Comprehensive Feeding Practices Questionnaire (CFPQ), while caregiver demographic characteristics, dietary beliefs, and intentions were measured through self-administered surveys. Hierarchical multiple linear regression was employed to identify predictors of feeding practices. RESULTS: The findings reveal that primary caregivers' feeding practices were shaped by multiple factors, including dietary beliefs (behavioral, normative, and control), intentions, and demographic characteristics. Each subscale of feeding practices was predicted by different factors, highlighting the unique influence of these factors on feeding behaviors. CONCLUSIONS: This study underscores the complex interplay between caregiver cognitive (dietary beliefs and intentions) and demographic factors in shaping feeding practices. The findings highlight the importance of targeting caregiver beliefs and intentions in interventions aimed at promoting healthier feeding practices, contributing to the prevention of childhood obesity. Importantly, future research is needed to explore these factors in more diverse populations and validate cognitive measures for broader application. FAU - Oudat, Qutaibah AU - Oudat Q AUID- ORCID: 0000-0003-2167-7371 AD - Department of Population Health, College of Nursing, University of Cincinnati, Cincinnati, OH 45221, USA. FAU - Lee, Rebecca C AU - Lee RC AD - Department of Population Health, College of Nursing, University of Cincinnati, Cincinnati, OH 45221, USA. FAU - Miller, Elaine L AU - Miller EL AUID- ORCID: 0000-0002-9074-7452 AD - Department of Population Health, College of Nursing, University of Cincinnati, Cincinnati, OH 45221, USA. FAU - Couch, Sarah Collins AU - Couch SC AD - Department of Rehabilitation, College of Allied Health Sciences, University of Cincinnati, Cincinnati, OH 45221, USA. FAU - Bakas, Tamilyn AU - Bakas T AUID- ORCID: 0000-0002-3235-5012 AD - Department of Population Health, College of Nursing, University of Cincinnati, Cincinnati, OH 45221, USA. LA - eng PT - Journal Article DEP - 20250213 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC11854846 OTO - NOTNLM OT - caregivers OT - comprehensive feeding practices OT - parents OT - preschoolers OT - theory of planned behavior COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2025/02/26 06:27 MHDA- 2025/02/26 06:28 PMCR- 2025/02/13 CRDT- 2025/02/26 01:11 PHST- 2025/01/21 00:00 [received] PHST- 2025/02/06 00:00 [revised] PHST- 2025/02/12 00:00 [accepted] PHST- 2025/02/26 06:28 [medline] PHST- 2025/02/26 06:27 [pubmed] PHST- 2025/02/26 01:11 [entrez] PHST- 2025/02/13 00:00 [pmc-release] AID - children12020226 [pii] AID - children-12-00226 [pii] AID - 10.3390/children12020226 [doi] PST - epublish SO - Children (Basel). 2025 Feb 13;12(2):226. doi: 10.3390/children12020226. PMID- 40003326 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250228 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 2 DP - 2025 Feb 13 TI - The Development of Standardized National Head Circumference Growth Charts for Jordanian Children Aged 0-5 Years: A Longitudinal and Cross-Sectional Study. LID - 10.3390/children12020224 [doi] LID - 224 AB - Background: Head circumference (HC) is a key indicator of growth and brain development in children, used to identify abnormalities like microcephaly and macrocephaly. While WHO growth standards are widely adopted, they may not account for regional variations due to genetic, environmental, and socio-economic factors. This study aimed to develop and validate national HC growth charts for Jordanian children aged 0-5 years and compare them with WHO standards. Method: This study analyzed 628,456 HC measurements from 250,276 Jordanian children (51.6% boys, 48.4% girls) aged 0-1800 days, using data from the Hakeem program. Only healthy children were included. HC measurements followed international guidelines, and data were analyzed using the Lambda-Mu-Sigma (LMS) statistical method. Percentiles were calculated, and growth patterns were compared with WHO standards. Results: National HC-for-age growth charts were developed for the 3rd, 15th, 50th, 85th, and 97th percentiles. Median percentiles for Jordanian children aligned with WHO standards, but the 3rd percentile was lower, particularly for girls after 840 days. The 97th percentile diverged after 240 days, with larger HC measurements observed in Jordanian children. Conclusions: This study provides the first validated HC growth charts for Jordanian children, addressing the limitations of international standards in reflecting regional variations. These charts offer clinicians and public health professionals a precise tool for assessing and monitoring growth, promoting better health outcomes in Jordanian children. FAU - Al-Qerem, Walid AU - Al-Qerem W AUID- ORCID: 0000-0001-9831-7572 AD - Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan. FAU - Jarab, Anan AU - Jarab A AUID- ORCID: 0000-0002-0416-506X AD - College of Pharmacy, Al Ain University, Abu Dhabi 112612, United Arab Emirates. AD - Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan. FAU - Al-Azayzih, Ahmad AU - Al-Azayzih A AD - Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan. AD - Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates. FAU - Eberhardt, Judith AU - Eberhardt J AUID- ORCID: 0000-0003-0745-178X AD - Department of Psychology, School of Social Sciences, Humanities and Law, Teesside University, Borough Road, Middlesbrough TS1 3BX, UK. FAU - Zumot, Ruba AU - Zumot R AD - Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan. FAU - Alasmari, Fawaz AU - Alasmari F AUID- ORCID: 0000-0003-2382-5892 AD - Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 12372, Saudi Arabia. FAU - Hammad, Alaa AU - Hammad A AUID- ORCID: 0000-0003-3800-1220 AD - Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan. LA - eng GR - RSP2025R235/King Saud University, Riyadh, Saudi Arabia/ PT - Journal Article DEP - 20250213 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC11854488 OTO - NOTNLM OT - Jordanian children OT - Lambda-Mu-Sigma statistical method OT - WHO standards OT - anthropometric measurements OT - growth charts OT - head circumference OT - macrocephaly OT - microcephaly OT - pediatric growth patterns OT - region-specific growth standards COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2025/02/26 06:28 MHDA- 2025/02/26 06:29 PMCR- 2025/02/13 CRDT- 2025/02/26 01:11 PHST- 2025/01/16 00:00 [received] PHST- 2025/02/08 00:00 [revised] PHST- 2025/02/11 00:00 [accepted] PHST- 2025/02/26 06:29 [medline] PHST- 2025/02/26 06:28 [pubmed] PHST- 2025/02/26 01:11 [entrez] PHST- 2025/02/13 00:00 [pmc-release] AID - children12020224 [pii] AID - children-12-00224 [pii] AID - 10.3390/children12020224 [doi] PST - epublish SO - Children (Basel). 2025 Feb 13;12(2):224. doi: 10.3390/children12020224. PMID- 40002866 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250228 IS - 2227-9059 (Print) IS - 2227-9059 (Electronic) IS - 2227-9059 (Linking) VI - 13 IP - 2 DP - 2025 Feb 12 TI - Ultrasound Assessment in Polycystic Ovary Syndrome Diagnosis: From Origins to Future Perspectives-A Comprehensive Review. LID - 10.3390/biomedicines13020453 [doi] LID - 453 AB - Background: Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy in women of reproductive age, characterized by a broad spectrum of clinical, metabolic, and ultrasound findings. Over time, ultrasound has evolved into a cornerstone for diagnosing polycystic ovarian morphology (PCOM), thanks to advances in probe technology, 3D imaging, and novel stromal markers. The recent incorporation of artificial intelligence (AI) further enhances diagnostic precision by reducing operator-related variability. Methods: We conducted a narrative review of English-language articles in PubMed and Embase using the keywords "PCOS", "polycystic ovary syndrome", "ultrasound", "3D ultrasound", and "ovarian stroma". Studies on diagnostic criteria, imaging modalities, stromal assessment, and machine-learning algorithms were prioritized. Additional references were identified via citation screening. Results: Conventional 2D ultrasound remains essential in clinical practice, with follicle number per ovary (FNPO) and ovarian volume (OV) functioning as primary diagnostic criteria. However, sensitivity and specificity values vary significantly depending on probe frequency, cut-off thresholds (>/=12, >/=20, or >/=25 follicles), and patient characteristics (e.g., adolescence, obesity). Three-dimensional (3D) ultrasound and Doppler techniques refine PCOS diagnosis by enabling automated follicle measurements, stromal/ovarian area ratio assessments, and evaluation of vascular indices correlating strongly with hyperandrogenism. Meanwhile, AI-driven ultrasound analysis has emerged as a promising tool for minimizing observer bias and validating advanced metrics (e.g., SA/OA ratio) that may overcome traditional limitations of stroma-based criteria. Conclusions: The continual evolution of ultrasound, encompassing higher probe frequencies, 3D enhancements, and now AI-assisted algorithms, has expanded our ability to characterize PCOM accurately. Nevertheless, challenges such as operator dependency and inter-observer variability persist despite standardized protocols; the integration of AI holds promise in further enhancing diagnostic accuracy. Future directions should focus on robust AI training datasets, multicenter validation, and age-/BMI-specific cut-offs to optimize the balance between sensitivity and specificity, ultimately facilitating earlier and more precise PCOS diagnoses. FAU - Di Michele, Stefano AU - Di Michele S AUID- ORCID: 0009-0005-9644-7919 AD - Division of Gynecology and Obstetrics, Department of Surgical Sciences, University of Cagliari, SS554, 4, Monserrato, 09042 Cagliari, Italy. FAU - Fulghesu, Anna Maria AU - Fulghesu AM AD - Division of Gynecology and Obstetrics, Department of Surgical Sciences, University of Cagliari, SS554, 4, Monserrato, 09042 Cagliari, Italy. FAU - Pittui, Elena AU - Pittui E AD - Division of Gynecology and Obstetrics, Department of Surgical Sciences, University of Cagliari, SS554, 4, Monserrato, 09042 Cagliari, Italy. FAU - Cordella, Martina AU - Cordella M AD - Division of Gynecology and Obstetrics, Department of Surgical Sciences, University of Cagliari, SS554, 4, Monserrato, 09042 Cagliari, Italy. FAU - Sicilia, Gilda AU - Sicilia G AUID- ORCID: 0009-0008-9890-955X AD - Division of Gynecology and Obstetrics, Department of Surgical Sciences, University of Cagliari, SS554, 4, Monserrato, 09042 Cagliari, Italy. FAU - Mandurino, Giuseppina AU - Mandurino G AD - Division of Gynecology and Obstetrics, Department of Surgical Sciences, University of Cagliari, SS554, 4, Monserrato, 09042 Cagliari, Italy. FAU - D'Alterio, Maurizio Nicola AU - D'Alterio MN AD - Division of Gynecology and Obstetrics, Department of Surgical Sciences, University of Cagliari, SS554, 4, Monserrato, 09042 Cagliari, Italy. FAU - Vitale, Salvatore Giovanni AU - Vitale SG AUID- ORCID: 0000-0001-6871-6097 AD - Division of Gynecology and Obstetrics, Department of Surgical Sciences, University of Cagliari, SS554, 4, Monserrato, 09042 Cagliari, Italy. FAU - Angioni, Stefano AU - Angioni S AUID- ORCID: 0000-0002-2314-0028 AD - Division of Gynecology and Obstetrics, Department of Surgical Sciences, University of Cagliari, SS554, 4, Monserrato, 09042 Cagliari, Italy. LA - eng PT - Journal Article PT - Review DEP - 20250212 PL - Switzerland TA - Biomedicines JT - Biomedicines JID - 101691304 PMC - PMC11853298 OTO - NOTNLM OT - 3D ultrasound OT - PCOM OT - PCOS OT - artificial intelligence OT - machine learning OT - ovarian stroma OT - sensitivity OT - specificity COIS- The authors declare no conflicts of interest. EDAT- 2025/02/26 06:27 MHDA- 2025/02/26 06:28 PMCR- 2025/02/12 CRDT- 2025/02/26 01:09 PHST- 2024/12/31 00:00 [received] PHST- 2025/02/07 00:00 [revised] PHST- 2025/02/11 00:00 [accepted] PHST- 2025/02/26 06:28 [medline] PHST- 2025/02/26 06:27 [pubmed] PHST- 2025/02/26 01:09 [entrez] PHST- 2025/02/12 00:00 [pmc-release] AID - biomedicines13020453 [pii] AID - biomedicines-13-00453 [pii] AID - 10.3390/biomedicines13020453 [doi] PST - epublish SO - Biomedicines. 2025 Feb 12;13(2):453. doi: 10.3390/biomedicines13020453. PMID- 40000415 OWN - NLM STAT- MEDLINE DCOM- 20250403 LR - 20260815 IS - 1463-1326 (Electronic) IS - 1462-8902 (Print) IS - 1462-8902 (Linking) VI - 27 IP - 5 DP - 2025 May TI - External validation of a prediction model for estimating fat mass in Arab children and adolescents. PG - 2740-2749 LID - 10.1111/dom.16281 [doi] AB - BACKGROUND/AIMS: Current childhood fat mass (FM) assessment techniques are not suitable for clinical and population-level adiposity assessment. A prediction model, which accurately estimates childhood FM using predictor variables of weight, height, age, sex and ethnicity, requires validation in Arab populations. We evaluate the model's performance in Kuwaiti, Lebanese and Moroccan children/adolescents. METHODS: Data from three cross-sectional studies on 471 individuals, aged 6-15 years, were obtained with complete information on predictors and the outcome of log transformed fat-free mass assessed by reference standard deuterium dilution (lnFFM). Country-specific predictive performance statistics of R(2), calibration slope and calibration-in-the-large (measures the calibration/agreement between observed and predicted lnFFM with ideal values of 1 and 0, respectively) and root mean square error (RMSE) were quantified and pooled across countries via random-effects meta-analysis. FM estimates from bioimpedance were also available for Lebanese children and were compared to the reference standard. RESULTS: The model showed strong predictive ability in all populations. Pooled R(2) calibration slope and calibration-in-the-large values on the original lnFFM scale were 87.73% (95% CI: 77.20, 98.26%), 0.95 (95% CI: 0.83, 1.08) and -0.03 (95% CI: -0.16, 0.11), respectively. Model intercepts were recalibrated in each country to improve accuracy; updated country-specific equations are provided. After recalibration, RMSEs on the FM scale were 1.3, 1.6 and 2.8 kg in Kuwait, Lebanon and Morocco, respectively. The RMSE from the model was lower than bioimpedance (2.4 kg) amongst Lebanese children. INTERPRETATION: The model explained a large proportion of the variance in FM, produced well-calibrated predictions and relatively low RMSEs in Arab settings. It predicted FM more accurately than bioimpedance, indicating its potential for implementation in clinical- and population-level settings, particularly in low- and middle-income countries. CI - (c) 2025 The Author(s). Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd. FAU - Al-Ati, Tareq AU - Al-Ati T AD - Food and Nutrition Program, Environment and Life Sciences Research Institute Center, Kuwait Institute for Scientific Research, Safat, Kuwait. FAU - El Kari, Khalid AU - El Kari K AD - RDC-Nutrition, Centre National de l'Energie Des Sciences et Techniques Nucleaires, Ibn Tofail University, Kenitra, Morocco. FAU - Nasreddine, Lara AU - Nasreddine L AD - Department of Nutrition and Food Sciences, American University of Beirut, Beirut, Lebanon. FAU - Al-Kandari, Hessa AU - Al-Kandari H AD - Department of Population Health, Dasman Diabetes Institute, Kuwait City, Kuwait. FAU - Riley, Richard D AU - Riley RD AD - School of Health Sciences, University of Birmingham, Birmingham, UK. FAU - Whincup, Peter H AU - Whincup PH AD - Population Health Research Institute, St George's School of Health & Medical Sciences, City St. George's University of London, London, UK. FAU - Owen, Christopher G AU - Owen CG AD - Population Health Research Institute, St George's School of Health & Medical Sciences, City St. George's University of London, London, UK. FAU - Hudda, Mohammed T AU - Hudda MT AUID- ORCID: 0000-0001-7894-1159 AD - Department of Population Health, Dasman Diabetes Institute, Kuwait City, Kuwait. LA - eng GR - Ref/Pfizer Inc. Global Obesity ASPIRE Research Grant/ GR - 91629725/Pfizer Inc. Global Obesity ASPIRE Research Grant/ GR - National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre/ PT - Journal Article PT - Validation Study DEP - 20250225 PL - England TA - Diabetes Obes Metab JT - Diabetes, obesity & metabolism JID - 100883645 SB - IM MH - Humans MH - Child MH - Adolescent MH - Male MH - Female MH - *Arabs/statistics & numerical data MH - Cross-Sectional Studies MH - Lebanon/epidemiology MH - *Adiposity MH - Kuwait/epidemiology MH - Morocco/epidemiology MH - *Body Composition MH - *Adipose Tissue MH - *Pediatric Obesity/diagnosis/epidemiology MH - Electric Impedance MH - Reproducibility of Results MH - Predictive Value of Tests PMC - PMC11964989 OTO - NOTNLM OT - body composition OT - meta-analysis OT - observational study OT - real-world evidence COIS- The authors confirm we have no competing interests. EDAT- 2025/02/26 00:20 MHDA- 2025/04/03 18:25 PMCR- 2025/04/03 CRDT- 2025/02/25 22:53 PHST- 2025/02/04 00:00 [revised] PHST- 2024/11/21 00:00 [received] PHST- 2025/02/07 00:00 [accepted] PHST- 2025/04/03 18:25 [medline] PHST- 2025/02/26 00:20 [pubmed] PHST- 2025/02/25 22:53 [entrez] PHST- 2025/04/03 00:00 [pmc-release] AID - DOM16281 [pii] AID - 10.1111/dom.16281 [doi] PST - ppublish SO - Diabetes Obes Metab. 2025 May;27(5):2740-2749. doi: 10.1111/dom.16281. Epub 2025 Feb 25. PMID- 40000089 OWN - NLM STAT- MEDLINE DCOM- 20250510 LR - 20250518 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 2 DP - 2025 Feb 25 TI - Depression among individuals with disabilities: a community-based cross-sectional study in Nepal. PG - e082955 LID - 10.1136/bmjopen-2023-082955 [doi] LID - e082955 AB - OBJECTIVE: To assess the prevalence of depression and its associated factors among individuals with disabilities. DESIGN: Cross-sectional study. SETTING: Community-based study conducted in Ilam municipality, Nepal, from October to November 2019. PARTICIPANTS: The study was conducted among 164 people with physical, hearing and vision-related disabilities. Participants were selected through a simple random sampling method using the sampling frame obtained from Ilam municipality. MAIN OUTCOME MEASURE: Depression and its associated factors among people with disabilities. Depression was assessed via a validated Nepali version of the Hospital Anxiety and Depression Scale. Data collection was based on a pretested structured questionnaire. RESULTS: The prevalence of depression was 39% among people with disabilities, and 29.9% of the respondents were in borderline depression. In an unadjusted analysis, depression was significantly (p<0.05) associated with comorbidities, absence of medical intervention, severe disabilities and disabilities acquired at birth. After adjusting for individual-level factors (age, sex, education, employment and physical activities), the level of disability and treatment accessibility were significantly associated with depression. After adjusting for family and community-level factors (economic status, experience of violence and social participation), depression remained significantly associated (p<0.05) with having comorbidities, absence of medical intervention and presence of very severe disabilities. When adjusting for both individual-level and community-level factors, the level of disability continued to show a significant association with depression (OR 6.36 (moderate vs mild), 2.11 (severe vs mild) and 13.3 (very severe vs mild), overall p-value of 0.045). Across all three adjusted models, the level of disability was significantly associated with depression (p<0.05). CONCLUSION: Depression is one of the major global public health concerns, with people with disabilities being particularly vulnerable. Ensuring the health and well-being of people with disabilities requires focused attention and strategic planning, emphasising disease prevention, health promotion and improved access to care. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Ghimire, Apekshya AU - Ghimire A AUID- ORCID: 0000-0001-7883-0141 AD - Department of Public Health, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal apekshyaghimire9@gmail.com. FAU - Mishra, Durga Kumari Khadka AU - Mishra DKK AD - Department of Public Health, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal. LA - eng PT - Journal Article DEP - 20250225 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Nepal/epidemiology MH - Cross-Sectional Studies MH - Male MH - Female MH - *Persons with Disabilities/psychology/statistics & numerical data MH - Adult MH - *Depression/epidemiology MH - Middle Aged MH - Prevalence MH - Young Adult MH - Aged MH - Adolescent MH - Risk Factors MH - Surveys and Questionnaires PMC - PMC12083256 OTO - NOTNLM OT - Cross-sectional studies OT - Depression & mood disorders OT - Disabled persons OT - Mental health OT - Nepal OT - Public health COIS- Competing interests: None declared. EDAT- 2025/02/26 00:20 MHDA- 2025/02/26 00:21 PMCR- 2025/02/25 CRDT- 2025/02/25 20:53 PHST- 2025/02/26 00:21 [medline] PHST- 2025/02/26 00:20 [pubmed] PHST- 2025/02/25 20:53 [entrez] PHST- 2025/02/25 00:00 [pmc-release] AID - bmjopen-2023-082955 [pii] AID - 10.1136/bmjopen-2023-082955 [doi] PST - epublish SO - BMJ Open. 2025 Feb 25;15(2):e082955. doi: 10.1136/bmjopen-2023-082955. PMID- 39997500 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250227 IS - 2308-3425 (Electronic) IS - 2308-3425 (Linking) VI - 12 IP - 2 DP - 2025 Feb 10 TI - Cardiological Aspects of Feeding and Eating Disorders in Children and Adolescents and Associations with Refeeding Syndrome, Purging Behaviors, and Psychoactive Drugs. LID - 10.3390/jcdd12020066 [doi] LID - 66 AB - Feeding and Eating Disorders (FEDs) constitute a complex spectrum of psychiatric conditions, impacting physical and psychosocial well-being. This retrospective observational study aimed to dissect the electrocardiographic (ECG) alterations in pediatric patients with FEDs, correlating them with clinical factors, treatment modalities, Refeeding Syndrome (RS) and the reversibility of ECG abnormalities post-treatment. Analyzing records from a third level Italian Regional Center for FEDs in children and adolescents, the study encompassed 150 patients meeting the inclusion criteria. Sinus bradycardia was the prevalent ECG alteration, notably in Anorexia Nervosa (AN) restrictive type. Association analyses revealed links between the severity of AN, hormonal imbalances, and amenorrhea and ECG abnormalities. Pharmacological interventions, particularly antipsychotics, exhibited associations with a QT interval prolongation. RS demonstrated significant correlations with potassium and magnesium imbalances, which were linked to specific ECG changes. This study highlighted the reversibility of ECG abnormalities, concomitant with Body Mass Index improvement. This analysis underscores the critical cardiac implications of FEDs, advocating for multidisciplinary interventions and close cardiac monitoring. Early detection and holistic care are imperative in managing patients with FEDs in the developmental age, offering potential reversibility of cardiac alterations post-treatment. These findings underscore the need for prospective studies to validate these observations and delve deeper into cardiac involvement in FEDs. FAU - Letizia, Chiara AU - Letizia C AD - IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Neuropsichiatria dell'Eta Pediatrica, Centro Regionale per i Disturbi della Nutrizione e dell'Alimentazione in Eta Evolutiva, 40139 Bologna, Italy. AD - Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), Universita di Bologna, 40126 Bologna, Italy. FAU - Pruccoli, Jacopo AU - Pruccoli J AUID- ORCID: 0000-0002-7540-0776 AD - IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Neuropsichiatria dell'Eta Pediatrica, Centro Regionale per i Disturbi della Nutrizione e dell'Alimentazione in Eta Evolutiva, 40139 Bologna, Italy. AD - Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), Universita di Bologna, 40126 Bologna, Italy. FAU - Pannacci, Umberto AU - Pannacci U AD - IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Neuropsichiatria dell'Eta Pediatrica, Centro Regionale per i Disturbi della Nutrizione e dell'Alimentazione in Eta Evolutiva, 40139 Bologna, Italy. AD - Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), Universita di Bologna, 40126 Bologna, Italy. FAU - Napolitano, Tania AU - Napolitano T AD - IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Neuropsichiatria dell'Eta Pediatrica, Centro Regionale per i Disturbi della Nutrizione e dell'Alimentazione in Eta Evolutiva, 40139 Bologna, Italy. AD - Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), Universita di Bologna, 40126 Bologna, Italy. FAU - Fabi, Marianna AU - Fabi M AUID- ORCID: 0000-0002-2727-3506 AD - Pediatric Emergency Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40139 Bologna, Italy. FAU - Parmeggiani, Antonia AU - Parmeggiani A AD - IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Neuropsichiatria dell'Eta Pediatrica, Centro Regionale per i Disturbi della Nutrizione e dell'Alimentazione in Eta Evolutiva, 40139 Bologna, Italy. AD - Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), Universita di Bologna, 40126 Bologna, Italy. LA - eng PT - Journal Article DEP - 20250210 PL - Switzerland TA - J Cardiovasc Dev Dis JT - Journal of cardiovascular development and disease JID - 101651414 PMC - PMC11856957 OTO - NOTNLM OT - Anorexia Nervosa OT - Bulimia Nervosa OT - Feeding and Eating Disorders OT - Refeeding Syndrome OT - cardiac complications OT - developmental age OT - electrocardiographic alterations COIS- The authors declare no conflicts of interest. EDAT- 2025/02/25 12:24 MHDA- 2025/02/25 12:25 PMCR- 2025/02/10 CRDT- 2025/02/25 08:25 PHST- 2024/11/07 00:00 [received] PHST- 2025/01/28 00:00 [revised] PHST- 2025/02/06 00:00 [accepted] PHST- 2025/02/25 12:25 [medline] PHST- 2025/02/25 12:24 [pubmed] PHST- 2025/02/25 08:25 [entrez] PHST- 2025/02/10 00:00 [pmc-release] AID - jcdd12020066 [pii] AID - jcdd-12-00066 [pii] AID - 10.3390/jcdd12020066 [doi] PST - epublish SO - J Cardiovasc Dev Dis. 2025 Feb 10;12(2):66. doi: 10.3390/jcdd12020066. PMID- 39996004 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250226 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - Prediction model for unfavorable treatment outcome for complicated sever acute malnutrition (SAM) in under five children admitted in hospitals at Amhara Region. PG - 1523975 LID - 10.3389/fnut.2025.1523975 [doi] LID - 1523975 AB - BACKGROUND: Severe acute malnutrition (SAM) affects 45 million children worldwide, with 14.89% of Ethiopian children under five suffering from it. This study validates a prediction model and develops risk scores for unfavorable treatment outcomes in SAM patients, addressing the scarcity of risk assessment tools in low-income settings and providing clinicians with a practical tool to improve decision-making. METHODS: A cohort study was conducted among 915 SAM children hospitalized with SAM hospitals in Amhara Region. Data analysis was conducted using STATA 17 and R 4.4.1. A lasso-selected multivariable model developed a nomogram for clinical utility. Model performance was assessed via AUC, calibration plot and validated with bootstrapping. Decision curve analysis evaluated the model's clinical and public health utility. RESULTS: The incidence of unfavorable treatment outcomes of SAM cases was 27.8% (95% CI: 25, 31). Majority of admitted children in stabilization center were complicated Severe Acute Malnutrition (cSAM) under-five children a magnitude of 89.52% (95% CI: 80.5-99.82). The developed nomogram comprised seven predictors: baseline Oedema, Diarrhea, CBC test results (Anemia), Pneumonia, Folic Acid supplementation, Vitamin A supplementation and IV antibiotic treatment. The AUC of the original model was 91.3% (95% CI: 89.0, 93.5), whereas the risk score model produced prediction accuracy of an AUC of 90.86 (95% CI: 88.6, 92.9). It was internally validated by bootstrapping method, and it has a relatively corrected discriminatory performance. Decision curve analysis indicated a higher net benefit compared to treating all or none, especially for threshold probabilities above 21%. CONCLUSION: Our model and risk score demonstrate excellent discrimination and calibration, with minimal accuracy loss from the original, ensuring robust predictive performance. The models can have the potential to improve care and treatment outcomes in the clinical settings. Healthcare professionals prioritize the management of cSAM cases in children, particularly those presenting with baseline edema and co-morbidities such as pneumonia, anemia and diarrhea. Emphasis should be placed on timely interventions, including the administration of folic acid and Vitamin A supplementation, as well as intravenous antibiotics. Implementing a comprehensive care plan that addresses these factors will significantly improve treatment outcomes and enhance recovery in this vulnerable population. CI - Copyright (c) 2025 Yeshiwas, Anteneh, Tsega, Fentaw Ahmed and Yenew. FAU - Yeshiwas, Almaw Genet AU - Yeshiwas AG AD - Department of Environmental Health, College of Medicine and Health Sciences, Injibara University, Injibara, Ethiopia. FAU - Anteneh, Zelalem Alamrew AU - Anteneh ZA AD - Departments of Epidemiology, School of Public Health, Bahir Dar University, Bahir Dar, Ethiopia. FAU - Tsega, Tilahun Degu AU - Tsega TD AD - Department of Public Health, College of Medicine and Health Sciences, Injibara University, Injibara, Ethiopia. FAU - Fentaw Ahmed, Ahmed AU - Fentaw Ahmed A AD - Department of Public Health, College of Medicine and Health Sciences, Injibara University, Injibara, Ethiopia. FAU - Yenew, Chalachew AU - Yenew C AD - Department of Environmental Health Sciences, Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia. LA - eng PT - Journal Article DEP - 20250210 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC11847673 OTO - NOTNLM OT - Amhara Region OT - Ethiopia OT - Sam OT - prediction OT - unfavorable treatment outcome COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/02/25 06:21 MHDA- 2025/02/25 06:22 PMCR- 2025/01/01 CRDT- 2025/02/25 04:43 PHST- 2024/11/06 00:00 [received] PHST- 2025/01/22 00:00 [accepted] PHST- 2025/02/25 06:22 [medline] PHST- 2025/02/25 06:21 [pubmed] PHST- 2025/02/25 04:43 [entrez] PHST- 2025/01/01 00:00 [pmc-release] AID - 10.3389/fnut.2025.1523975 [doi] PST - epublish SO - Front Nutr. 2025 Feb 10;12:1523975. doi: 10.3389/fnut.2025.1523975. eCollection 2025. PMID- 39994406 OWN - NLM STAT- MEDLINE DCOM- 20250224 LR - 20250509 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Feb 24 TI - Association between social media use, physical activity level, and depression and anxiety among college students: a cross-cultural comparative study. PG - 6596 LID - 10.1038/s41598-025-88140-y [doi] LID - 6596 AB - This article examined the interaction of social media use and physical activity with mental health outcomes in a cultural and regional perspective among university students in China. Among 1,500 students from ten universities across different regions of China, stratified random sampling was used to complete the validated measures of social media use, physical activity, depression, anxiety, sleep quality, and cultural values. Significantly positive associations were revealed between the use of social media and both depressive symptoms, r = .28, p /=7.05, respectively. In addition, umbilical cord arterial pH thresholds at 6.95, 7.00, 7.05, 7.10, 7.15, and 7.20 were evaluated for mental and behavioral disorders. RESULTS: Of the 35,931 births that met the inclusion criteria of complete and validated data, 912 (2.5%) had acidemia (umbilical cord arterial pH <7.05) at birth, while 35,019 (97.5%) had nonacidemic values (pH >/=7.05). Acidemia was associated with higher mortality (P=.043). Among groups of organ system diseases, a pH <7.05 was not associated with increased risk of disease. At the group level, the risk was not significantly increased for mental and behavioral disorders (crude hazard ratio 1.05, 95% confidence interval 0.75-1.46); however, subanalysis showed an increased risk of cerebral palsy (crude hazard ratio 4.30, 95% confidence interval 2.16-8.58) and epilepsy (crude hazard ratio 1.70, 95% confidence interval 1.02-2.86). After adjustment for maternal age, parity, smoking, body mass index, and gestational age, the associations strengthened (cerebral palsy adjusted hazard ratio 4.35, 95% confidence interval 2.17-8.73), (epilepsy adjusted hazard ratio 1.71, 95% confidence interval 1.02-2.88). The threshold of umbilical cord arterial pH <6.95 was significantly associated with increased risk of cerebral palsy (hazard ratio 18.38, 95% confidence interval 7.34-46.08), epilepsy (hazard ratio 8.16, 95% confidence interval 4.18-15.92), and intellectual disability (hazard ratio 4.19, 95% confidence interval 1.73-10.17), whereas thresholds 7.00, 7.05, 7.10, and 7.15 were not. CONCLUSION: Neonatal acidemia, defined as cord arterial pH <7.05, was associated with an increased risk of death, cerebral palsy, and epilepsy, but not of other types of mental and behavioral disorders or other organ system diseases. An umbilical cord arterial pH <6.95 was significantly associated with cerebral palsy, epilepsy, and intellectual disability whereas pH <7.00 and other thresholds between 7.05 and 7.20 were not. CI - Copyright (c) 2025 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Zaigham, Mehreen AU - Zaigham M AD - Obstetrics and Gynecology, Institution of Clinical Sciences Lund, Lund University, Lund, Sweden; Department of Obstetrics and Gynecology, Skane University Hospital, Malmo, Sweden. Electronic address: mehreen.zaigham@med.lu.se. FAU - Kallen, Karin AU - Kallen K AD - Institution of Clinical Sciences Lund, Center for Reproductive Epidemiology, Tornblad Institute, Lund University, Lund, Sweden. FAU - Sundberg, Tiia-Marie AU - Sundberg TM AD - Obstetrics and Gynecology, Institution of Clinical Sciences Lund, Lund University, Lund, Sweden. FAU - Olofsson, Per AU - Olofsson P AD - Institution of Clinical Sciences Malmo, Lund University, Malmo, Sweden. LA - eng PT - Journal Article DEP - 20250219 PL - United States TA - Am J Obstet Gynecol JT - American journal of obstetrics and gynecology JID - 0370476 SB - IM MH - Humans MH - Infant, Newborn MH - *Acidosis/epidemiology/blood/complications MH - Retrospective Studies MH - Female MH - Sweden/epidemiology MH - *Fetal Blood/chemistry MH - Hydrogen-Ion Concentration MH - Male MH - Registries MH - Adult MH - Follow-Up Studies MH - Cerebral Palsy/epidemiology MH - Infant OTO - NOTNLM OT - acidemia OT - asphyxia OT - birth OT - cerebral palsy OT - epilepsy OT - intellectual disability OT - long-term outcome OT - morbidity OT - mortality OT - umbilical cord pH EDAT- 2025/02/22 00:22 MHDA- 2025/08/31 19:49 CRDT- 2025/02/21 19:35 PHST- 2024/10/17 00:00 [received] PHST- 2025/01/30 00:00 [revised] PHST- 2025/02/12 00:00 [accepted] PHST- 2025/08/31 19:49 [medline] PHST- 2025/02/22 00:22 [pubmed] PHST- 2025/02/21 19:35 [entrez] AID - S0002-9378(25)00109-7 [pii] AID - 10.1016/j.ajog.2025.02.028 [doi] PST - ppublish SO - Am J Obstet Gynecol. 2025 Sep;233(3):195.e1-195.e11. doi: 10.1016/j.ajog.2025.02.028. Epub 2025 Feb 19. PMID- 39982969 OWN - NLM STAT- MEDLINE DCOM- 20250221 LR - 20261007 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 2 DP - 2025 TI - Cross-validation of prediction equations for estimating the body mass index in adults without the use of body weight. PG - e0316610 LID - 10.1371/journal.pone.0316610 [doi] LID - e0316610 AB - INTRODUCTION: Body Mass Index (BMI) is a widely accepted measure by the World Health Organization for assessing body composition, as it provides critical insights into health risks, life expectancy, and quality of life. However, in resource-limited settings, access to weighing scales is often inadequate, and environmental conditions, such as unstable terrain, may hinder accurate weight measurements. In these contexts, alternative methods for estimating BMI become essential for effective health assessment. This study aimed to develop and validate equations to estimate BMI without relying on body weight, providing a practical tool for nutritional assessment where traditional methods are not feasible. MATERIALS AND METHODS: Adults aged 18 to 59 of both sexes were included. Variables like waist circumference, height, hip circumference, age, and weight were used for equation development and validation. Participants were divided by sex, with regression and validation subgroups for each. Statistical tests included Student's t-tests, Pearson correlation, Stepwise Regression, Intraclass Correlation Coefficient, Weighted Kappa Coefficient, and Bland-Altman statistics. RESULTS: The study included 810 adults, with 63% (576) women. No significant differences were found in paired comparisons between regression and validation subgroups for both sexes (p > 0.05). Four equations were proposed for BMI estimation: EM2 and EM3 for males, and EF2 and EF3 for females. All equations showed strong positive correlations (r > 0.90), significant at p < 0.05. Regression analysis revealed R2 values between 0.861 and 0.901 (p < 0.000). Intraclass Correlation Coefficient values indicated agreement of 0.961 and 0.972 (p < 0.05), with Weighted Kappa values showing substantial agreement of 0.658 and 0.711 for both sexes (p < 0.05). CONCLUSION: Adopting the proposed equations for estimating BMI in adults without using body weight is safe and effective for measuring this body measure in this population, particularly when weighing these individuals is not feasible. CI - Copyright: (c) 2025 Nunes Filho et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Nunes Filho, Julio Cesar Chaves AU - Nunes Filho JCC AUID- ORCID: 0000-0002-5513-5186 AD - Medical Sciences Postgraduate Program, Federal University of Ceara, Fortaleza, Brazil. AD - Department of Clinical Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil. FAU - Nunes, Marilia Porto Oliveira AU - Nunes MPO AD - Department of Nutrition, University of Fortaleza, Fortaleza, Ceara, Brazil. FAU - de Matos, Robson Salviano AU - de Matos RS AUID- ORCID: 0000-0003-1349-8170 AD - Department of Biomedicine, Federal University of Ceara, Fortaleza, Ceara, Brazil. AD - Fortaleza City Hall, Education Department, Fortaleza, Ceara, Brazil. FAU - Pinto, Daniel Vieira AU - Pinto DV AUID- ORCID: 0000-0001-7846-7258 AD - Brazilian Hospital Services Company/ Federal University of Amazonas, Manaus, Amazonas, Brazil. FAU - Pereira, Dyego Castelo Branco Holanda Gadelha AU - Pereira DCBHG AUID- ORCID: 0000-0001-7091-1019 AD - Medical Sciences Postgraduate Program, Federal University of Ceara, Fortaleza, Brazil. AD - Department of Clinical Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil. FAU - Branco, Thais Amanda Silva Pereira Castelo AU - Branco TASPC AUID- ORCID: 0000-0002-8657-4501 AD - Department of Clinical Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil. FAU - Da Silva Junior, Geraldo Bezerra AU - Da Silva Junior GB AD - Medical Sciences and Public Health Graduate Programs, School of Medicine, University of Fortaleza, Fortaleza, Ceara, Brazil. FAU - Ramalho, Janaina de Almeida Mota AU - Ramalho JAM AD - Medical Sciences Postgraduate Program, Federal University of Ceara, Fortaleza, Brazil. AD - Department of Clinical Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil. FAU - Daher, Elizabeth De Francesco AU - Daher EF AD - Medical Sciences Postgraduate Program, Federal University of Ceara, Fortaleza, Brazil. AD - Department of Clinical Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250221 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Adult MH - Male MH - Female MH - *Body Mass Index MH - Middle Aged MH - *Body Weight MH - Young Adult MH - Adolescent MH - Waist Circumference MH - Body Composition PMC - PMC11844915 COIS- The authors have declared that no competing interests exist. EDAT- 2025/02/21 18:20 MHDA- 2025/02/21 18:21 PMCR- 2025/02/21 CRDT- 2025/02/21 13:54 PHST- 2024/04/25 00:00 [received] PHST- 2024/12/13 00:00 [accepted] PHST- 2025/02/21 18:21 [medline] PHST- 2025/02/21 18:20 [pubmed] PHST- 2025/02/21 13:54 [entrez] PHST- 2025/02/21 00:00 [pmc-release] AID - PONE-D-24-15701 [pii] AID - 10.1371/journal.pone.0316610 [doi] PST - epublish SO - PLoS One. 2025 Feb 21;20(2):e0316610. doi: 10.1371/journal.pone.0316610. eCollection 2025. PMID- 39982128 OWN - NLM STAT- MEDLINE DCOM- 20250506 LR - 20250506 IS - 1530-0293 (Electronic) IS - 0090-3493 (Print) IS - 0090-3493 (Linking) VI - 53 IP - 5 DP - 2025 May 1 TI - Development of a Core Critical Care Data Dictionary With Common Data Elements to Characterize Critical Illness and Injuries Using a Modified Delphi Method. PG - e1045-e1054 LID - 10.1097/CCM.0000000000006595 [doi] AB - OBJECTIVES: To develop the first core Critical Care Data Dictionary (C2D2) with common data elements (CDEs) to characterize critical illness and injuries. DESIGN: Group consensus process using modified Delphi approach. SETTING: Electronic surveys and in-person meetings. SUBJECTS: A multidisciplinary workgroup of clinicians and researchers with expertise in the care of the critically ill and injured. INTERVENTIONS: The Delphi process was divided into domain and CDE portions with each composed of two item generation rounds and one item reduction/refinement rounds. Two in-person meetings augmented this process to facilitate review and consideration of the domains and by panel members. The final set of domains and CDEs was then reviewed by the group to meet the competing criteria of utility and feasibility, resulting in the core dataset. MEASUREMENTS AND MAIN RESULTS: The 23-member Delphi panel was provided 1833 candidate variables for potential dataset inclusion. The final dataset includes 226 patient-level CDCs in nine domains, which include anthropometrics and demographics (8), chronic comorbid illnesses (18), advanced directives (1), ICU diagnoses (61), diagnostic tests (42), interventions (27), medications (38), objective assessments (26), and hospital course and outcomes (5). Upon final review, 91% of the panel endorsed the CDCs as meeting criteria for a minimum viable data dictionary. Data elements cross the lifespan of neonate through adult patients. CONCLUSIONS: The resulting C2D2 provides a foundation to facilitate rapid collection, analyses, and dissemination of information necessary for research, quality improvement, and clinical practice to optimize critical care outcomes. Further work is needed to validate the effectiveness of the dataset in a variety of critical care settings. CI - Copyright (c) 2025 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. FAU - Murphy, David J AU - Murphy DJ AD - Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA. FAU - Anderson, Wesley AU - Anderson W AD - Critical Path Institute, Tuscon, AZ. FAU - Heavner, Smith H AU - Heavner SH AD - Critical Path Institute, Tuscon, AZ. FAU - Al-Hakim, Tamara AU - Al-Hakim T AD - Society of Critical Care Medicine, Mount Prospect, IL. FAU - Cruz-Cano, Raul AU - Cruz-Cano R AD - Department of Epidemiology & Biostatistics, Indiana University Bloomington, Bloomington, IN. FAU - Laudanski, Krzysztof AU - Laudanski K AD - Division of Critical Care Medicine, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN. FAU - Kamaleswaran, Rishikesan AU - Kamaleswaran R AD - Department of Biomedical Informatics, Duke University, Durham, NC. FAU - Badawi, Omar AU - Badawi O AD - National Evaluation System for Health Technology, Arlington, VA. FAU - Engel, Heidi AU - Engel H AD - Department of Rehabilitative Services, University of California San Francisco, San Francisco, CA. FAU - Grunwell, Jocelyn AU - Grunwell J AD - Department of Pediatrics, Emory University, Atlanta, GA. FAU - Herasevich, Vitaly AU - Herasevich V AD - Division of Critical Care Medicine, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN. FAU - Khanna, Ashish K AU - Khanna AK AD - Department of Anesthesiology, Section on Critical Care Medicine, Wake Forest University, Winston-Salem, NC. FAU - Lamb, Keith AU - Lamb K AD - Pulmonary Diagnostics & Respiratory Therapy Services, University of Virginia Medical Center, Charlottesville, VA. FAU - MacLaren, Robert AU - MacLaren R AD - Department of Clinical Pharmacy, University of Colorado, Aurora, CO. FAU - Rincon, Teresa AU - Rincon T AD - School of Nursing, University of Massachusetts, Amherst, MA. FAU - Sanchez-Pinto, Lazaro AU - Sanchez-Pinto L AD - Division of Health and Biomedical Informatics, Department of Preventive Medicine, Northwestern University, Evanston, IL. FAU - Sikora, Andrea N AU - Sikora AN AD - Department of Biomedical Informatics, University of Colorado School of Medicine, Aurora, CO. FAU - Stevens, Robert D AU - Stevens RD AD - Department of Anesthsiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD. FAU - Tanner, Donna AU - Tanner D AD - Department of Intensive Care and Resuscitation, Cleveland Clinic, Cleveland, OH. FAU - Teeter, William AU - Teeter W AD - Department of Emergency Medicine, University of Maryland, Baltimore, MD. FAU - Wong, An-Kwok Ian AU - Wong AI AD - Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University, Durham, NC. FAU - Wynn, James L AU - Wynn JL AD - Department of Pediatrics, University of Florida, Gainesville, FL. FAU - Zhang, Xiaohan T AU - Zhang XT AD - Department of Medicine, Johns Hopkins University, Baltimore, MD. FAU - Zimmerman, Jerry J AU - Zimmerman JJ AD - Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Washington, Seattle, WA. FAU - Kumar, Vishakha AU - Kumar V AD - Society of Critical Care Medicine, Mount Prospect, IL. FAU - Cobb, J Perren AU - Cobb JP AD - Division of Trauma, Emergency Surgery and Surgical Critical Care, Department of Surgery, University of Southern California, Los Angeles, CA. FAU - Reuter-Rice, Karin E AU - Reuter-Rice KE AD - School of Nursing, Duke University, Durham, NC. LA - eng PT - Journal Article DEP - 20250221 PL - United States TA - Crit Care Med JT - Critical care medicine JID - 0355501 SB - IM CIN - doi: 10.1097/CCM.0000000000006639 MH - Humans MH - *Delphi Technique MH - *Critical Illness/therapy MH - *Critical Care/statistics & numerical data MH - *Common Data Elements MH - *Wounds and Injuries/therapy MH - Consensus MH - Female PMC - PMC12047641 OTO - NOTNLM OT - adult OT - common data elements OT - intensive care OT - neonates OT - pediatric OT - standard definitions COIS- Drs. Murphy's and Sikora's institutions received funding from the Agency for Health Care Research and Quality. Dr. Murphy's institution received funding from the Centers for Disease Control and Prevention. Dr. Cruz-Cano's institution received funding from the Society of Critical Care Medicine (SCCM). Dr. Kamaleswaran's institution received funding from the National Institutes of Health (NIH). Drs. Kamaleswaran, Sikora, Tanner, and Wong received support for article research from the NIH. Dr. Badawi received funding from Ceiba Healthcare and CLEW Medical. Dr. Khanna received funding from Medtronic, Edwards Life Sciences, Philips Research North America, GE Healthcare, Retia Medical, Caretaker Medical, BrainX, the Canadian Institutes of Health Research, the Department of Defense, the National Heart, Lung, and Blood Institute, and the National Center for Advancing Translational Sciences. Dr. Rincon received funding from Blue Cirrus Consulting, Baxter Health Consulting, Viven Health, Phillips Health, Hospital Insurance Forum, and Illinois Health and Hospital Association. Drs. Wong, Zimmerman, and Cobb received funding from the SCCM. Dr. Wong received funding from Ataia Medical. Dr. Wynn received funding from Sobi. Dr. Zhang received support for article research from the SCCM. Dr. Zimmerman's institution received funding from the National Institute of Child Health and Human Development and Immunexpress. Drs. Zimmerman and Reuter-Rice received funding from Elsevier Publishing. Dr. Cobb received funding from Giblib, Akido Labs, and Bauhealth. Dr. Reuter-Rice's institution received funding from the National Institute of Neurological Disorders and Stroke; she received funding from Delphi. The remaining authors have disclosed that they do not have any potential conflicts of interest. EDAT- 2025/02/21 12:22 MHDA- 2025/05/06 12:42 PMCR- 2025/05/02 CRDT- 2025/02/21 09:32 PHST- 2025/05/06 12:42 [medline] PHST- 2025/02/21 12:22 [pubmed] PHST- 2025/02/21 09:32 [entrez] PHST- 2025/05/02 00:00 [pmc-release] AID - 00003246-990000000-00468 [pii] AID - CCMED-D-24-01099 [pii] AID - 10.1097/CCM.0000000000006595 [doi] PST - ppublish SO - Crit Care Med. 2025 May 1;53(5):e1045-e1054. doi: 10.1097/CCM.0000000000006595. Epub 2025 Feb 21. PMID- 39981916 OWN - NLM STAT- MEDLINE DCOM- 20250411 LR - 20260504 IS - 0975-5764 (Electronic) IS - 1596-3519 (Print) IS - 0975-5764 (Linking) VI - 24 IP - 2 DP - 2025 Apr 1 TI - Magnetic Resonance Imaging Versus Anthropometric Parameters in Predicting Hamstring Graft Length for Anterior Cruciate Ligament Surgery. PG - 337-344 LID - 10.4103/aam.aam_195_24 [doi] AB - CONTEXT: With the increasing number of anterior cruciate ligament reconstruction (ACLR) surgeries following sports injuries, situations may arise where hamstring graft is found to be inadequate. The authors hypothesized that the harvested hamstring graft length may be predicted preoperatively from both magnetic resonance imaging (MRI) and anthropometric parameters in ACLR surgery. AIMS: The study aimed at assessing the relationship between anthropometric and MRI parameters and hamstring graft length. SETTINGS AND DESIGN: The study is a prospective, observational, and comparative study. SUBJECT AND METHODS: A total of 52 patients recruited for ACLR were prospectively evaluated. Anthropometric parameters and Tegner activity score before the injury were recorded. Eight linear MRI measurements were obtained by two observers at an interval of 0 and 30 days. Semitendinosus (ST) and gracilis (G) tendons were harvested and a semitendinosus gracilis (STG) was prepared by a standard technique, and the lengths calculated. STATISTICAL ANALYSIS USED: The intra- and inter-rater reliability of the MRI measurements was measured. Pearson's ( r ) and Spearman's ( rho ) correlation coefficients were calculated, and linear regression analysis was performed to establish a relationship between the preoperative parameters and hamstring graft length. RESULTS: The mean graft length for ST was 29.44 +/- 1.89 cm and G was 24.44 +/- 3.34 cm. The final STG graft length was 8.98 +/- 0.19 cm. Transepicondylar distance (TD) had the highest intra- and inter-observer reliability among the MRI measurements. Univariate linear regression analysis revealed that height, weight, thigh length (TL), leg length, and TD were predictive of ST ( R2 range: 0.240-0.380) and G graft ( R2 range: 0.104-0.299) lengths. TL, body mass index, TD, and lateral femoral condyle anteroposterior dimension (LFAP) were predictive of STG graft length ( R2 range: 0.076-0.215). On multiple regression analysis, height and TD were significant predictors of ST ( R2: 0.449) and G lengths ( R2: 0.288). CONCLUSIONS: Our study concludes that anthropometric parameters may be supplemented with MRI measurements for accurate hamstring graft size predictions. CI - Copyright (c) 2025 Annals of African Medicine. FAU - Gupta, Govindkumar AU - Gupta G AD - Department of Orthopedics, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India. FAU - Chakraborty, Ratnajeet AU - Chakraborty R FAU - Shukla, Gauravkumar AU - Shukla G LA - eng LA - fre PT - Comparative Study PT - Journal Article PT - Observational Study DEP - 20250221 PL - India TA - Ann Afr Med JT - Annals of African medicine JID - 101231417 SB - IM MH - Humans MH - *Magnetic Resonance Imaging/methods MH - *Anterior Cruciate Ligament Reconstruction/methods MH - Male MH - Prospective Studies MH - Female MH - Adult MH - *Anthropometry MH - *Hamstring Tendons/transplantation/diagnostic imaging/anatomy & histology MH - Young Adult MH - *Anterior Cruciate Ligament Injuries/surgery/diagnostic imaging MH - Reproducibility of Results MH - Adolescent MH - *Anterior Cruciate Ligament/surgery/diagnostic imaging MH - *Hamstring Muscles/transplantation MH - *Tendons/transplantation PMC - PMC12103119 OTO - NOTNLM OT - Anterior cruciate ligament reconstruction OT - Blessures sportives OT - MRI OT - gracilis OT - magnetic resonance imaging OT - reconstruction du ligament croise anterieur OT - semitendinosus OT - sports injuries COIS- There are no conflicts of interest. EDAT- 2025/02/21 12:22 MHDA- 2025/04/11 06:25 PMCR- 2025/02/21 CRDT- 2025/02/21 07:54 PHST- 2024/10/01 00:00 [received] PHST- 2024/12/11 00:00 [accepted] PHST- 2025/04/11 06:25 [medline] PHST- 2025/02/21 12:22 [pubmed] PHST- 2025/02/21 07:54 [entrez] PHST- 2025/02/21 00:00 [pmc-release] AID - 01244624-202504000-00021 [pii] AID - AAM-24-337 [pii] AID - 10.4103/aam.aam_195_24 [doi] PST - ppublish SO - Ann Afr Med. 2025 Apr 1;24(2):337-344. doi: 10.4103/aam.aam_195_24. Epub 2025 Feb 21. PMID- 39981758 OWN - NLM STAT- MEDLINE DCOM- 20250410 LR - 20260517 IS - 1554-527X (Electronic) IS - 0736-0266 (Print) IS - 0736-0266 (Linking) VI - 43 IP - 5 DP - 2025 May TI - Validity of the Uninjured Limb as a Control for Preoperative Assessment in Anterior Cruciate Ligament Reconstruction. PG - 962-972 LID - 10.1002/jor.26057 [doi] AB - Monitoring muscle atrophy in patients undergoing anterolateral cruciate ligament reconstruction is pivotal for optimizing postoperative recovery. Conventionally, the uninjured contralateral limb serves as the control. However, its relevance in patients with prolonged physical activity hiatus due to knee instability remains uncertain. Our objectives were to compare limbs within a control group by assessing combined force measurements, cross-sectional areas (CSAs), and neuromuscular activation. In addition, we compared the contralateral limb of the surgery group preoperatively to the control group. This prospective controlled study (evidence level 2) included 40 healthy subjects (HG) and 30 patients scheduled for ACL surgery (SG). Both groups underwent identical assessments. The two HG limbs were compared to establish the standard difference for all assessed variables, whereas SG contralateral limb was compared with the mean of the control limbs. For HG, the comparisons between limbs showed no significant differences in muscle strength, CSA area, or electromyographic parameters. Similarly, comparisons between the SG contralateral limb and the mean of HG limbs revealed no significant differences in isometric and dynamic strength for the quadriceps and hamstrings (2.5 +/- 0.5 and 2.6 +/- 0.9 N.m/kg, and 1.7 +/- 0.3 and 1.7 +/- 0.4 N.m/kg, respectively). Neuromuscular activation and fatigue patterns were also comparable between groups. CSAs discrepancies were attributed to differences in body mass index between groups. These findings indicate that the contralateral limb in ACL_injured patients is functionally similar to that of healthy controls, supporting its use as a valid reference for monitoring postoperative recovery. Trial Registration: NCT03200678. CI - (c) 2025 The Author(s). Journal of Orthopaedic Research(R) published by Wiley Periodicals LLC on behalf of Orthopaedic Research Society. FAU - Grimandi, Ronan AU - Grimandi R AUID- ORCID: 0000-0002-4987-9998 AD - ORPHY, EA4324, Universite de Brest, Brest, France. AD - Medecine Physique et Rehabilitation, Hopital d'Instruction des Armees Clermont-Tonnerre (HIA-CT), Brest, France. FAU - Tissier, Florine AU - Tissier F AD - ORPHY, EA4324, Universite de Brest, Brest, France. FAU - Garetier, Marc AU - Garetier M AD - Service de Radiologie, Hopital d'Instruction des Armees Clermont-Tonnerre (HIA-CT), Brest, France. FAU - Labban, Julien AU - Labban J AD - Clinique Mutualiste de Bretagne Occidentale, Quimper, France. FAU - Gerard, Romain AU - Gerard R AD - Institut de chirurgie de l'appareil locomoteur d'Iroise, Brest, France. FAU - Courtois-Communier, Emmanuelle AU - Courtois-Communier E AD - Direction de la Recherche Clinique et de l'Innovation, CHU de Brest, Brest, France. FAU - Andro, Christophe AU - Andro C AD - Service de Chirurgie Orthopedie, Hopital d'Instruction des Armees Clermont-Tonnerre (HIA-CT), Brest, France. FAU - Bisseriex, Helene AU - Bisseriex H AD - Medecine Physique et Rehabilitation, Hopital d'Instruction des Armees Clermont-Tonnerre (HIA-CT), Brest, France. FAU - Gunepin, Francois-Xavier AU - Gunepin FX AD - Clinique Mutualiste de la Porte de l'Orient, Lorient, France. FAU - Rannou, Fabrice AU - Rannou F AD - Medecine du Sport et Explorations Fonctionnelles-ASMS (UNH), Hopital Gabriel Montpied, CHU Clermont-Ferrand, Brest, France. FAU - Giroux-Metges, Marie-Agnes AU - Giroux-Metges MA AD - ORPHY, EA4324, Universite de Brest, Brest, France. AD - Explorations Fonctionnelles Respiratoires, CHRU de Brest, Brest, France. LA - eng SI - ClinicalTrials.gov/NCT03200678 GR - This research was supported by the French Health Military Service (grant number [2017RC01]), which depends on the French Army Minister (Direction Centrale du Service de Sante des Armees, DCSSA, 60 Boulevard du General Martial VALIN CS 21623 75509 PARIS cedex 15)./ PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250221 PL - United States TA - J Orthop Res JT - Journal of orthopaedic research : official publication of the Orthopaedic Research Society JID - 8404726 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Young Adult MH - *Anterior Cruciate Ligament Injuries/surgery MH - *Anterior Cruciate Ligament Reconstruction MH - Electromyography MH - Muscle Strength MH - *Muscular Atrophy MH - Prospective Studies PMC - PMC11982620 OTO - NOTNLM OT - ACLR OT - MRI OT - disuse OT - isokinetic OT - surface electromyography COIS- The authors declare no conflicts of interest. EDAT- 2025/02/21 12:22 MHDA- 2025/04/10 06:24 PMCR- 2025/04/10 CRDT- 2025/02/21 06:53 PHST- 2025/01/18 00:00 [revised] PHST- 2024/10/29 00:00 [received] PHST- 2025/02/02 00:00 [accepted] PHST- 2025/04/10 06:24 [medline] PHST- 2025/02/21 12:22 [pubmed] PHST- 2025/02/21 06:53 [entrez] PHST- 2025/04/10 00:00 [pmc-release] AID - JOR26057 [pii] AID - 10.1002/jor.26057 [doi] PST - ppublish SO - J Orthop Res. 2025 May;43(5):962-972. doi: 10.1002/jor.26057. Epub 2025 Feb 21. PMID- 39981107 OWN - NLM STAT- MEDLINE DCOM- 20250509 LR - 20250509 IS - 2046-1402 (Electronic) IS - 2046-1402 (Linking) VI - 13 DP - 2024 TI - Predicting stunting status among under-5 children in Rwanda using neural network model: Evidence from 2020 Rwanda demographic and health survey. PG - 128 LID - 10.12688/f1000research.141458.2 [doi] LID - 128 AB - BACKGROUND: Stunting is a serious public health concern in Rwanda, affecting around 33.3% of children under five in 2020. The researchers have employed machine learning algorithms to predict stunting in Rwanda; however, few studies used ANNs, despite their strong capacity to predict stunting. The purpose of this study was to predict stunting in Rwanda using ANNs and the most recent DHS data from 2020. METHODS: DHS 2020 dataset was used to train and test an ANN model for predicting stunting in children. The dataset, which included various child, parental, and socio-demographic characteristics, was split into 80% training data and 20% testing and validation data. The model utilised a multilayer perceptron (MLP). Model performance was assessed using accuracy, precision, recall, and AUC-ROC. Feature importances were determined and highlighted the most critical predictors of stunting. RESULTS: An overall accuracy of 72.0% on the test set was observed, with an AUC-ROC of 0.84, indicating the model's good performance. Factors appear to contribute to stunting among the negative value aspects. First and foremost, the mother's height is important, as a lower height suggests an increased risk of stunting in children. Positive value characteristics, on the other hand, emphasise elements that reduce the likelihood of stunting. The timing of the initiation of breastfeeding stands out as a crucial factor, showing that early breastfeeding initiation has been linked with a decreased risk of stunting. CONCLUSIONS: These findings suggest that ANNs can be a useful tool for predicting stunting in Rwanda and identifying the most important associated factors for stunting. These insights can inform targeted interventions to reduce the burden of stunting in Rwanda and other low- and middle-income countries. Potential targeted interventions include nutritional support programs for pregnant and lactating mothers, and providing educational programs for parents on nutrition and hygiene. CI - Copyright: (c) 2025 Ndagijimana S et al. FAU - Ndagijimana, Similien AU - Ndagijimana S AUID- ORCID: 0000-0002-5636-3551 AD - African Centre of Excellence in Data Science, Kigali, Kigali, Rwanda. FAU - Kabano, Ignace AU - Kabano I AD - African Centre of Excellence in Data Science, Kigali, Kigali, Rwanda. AD - College of Business and Economics, University of Rwanda, Kigali, Kigali, Rwanda. FAU - Masabo, Emmanuel AU - Masabo E AD - African Centre of Excellence in Data Science, Kigali, Kigali, Rwanda. AD - College of science and Technology, University f Rwanda, Kigali, Kigali, Rwanda. FAU - Ntaganda, Jean Marie AU - Ntaganda JM AUID- ORCID: 0000-0003-2464-2377 AD - College of Business and Economics, University of Rwanda, Kigali, Kigali, Rwanda. LA - eng PT - Journal Article DEP - 20250120 PL - England TA - F1000Res JT - F1000Research JID - 101594320 SB - IM MH - Humans MH - Rwanda/epidemiology MH - *Growth Disorders/epidemiology/diagnosis MH - Child, Preschool MH - Infant MH - Female MH - Male MH - *Neural Networks, Computer MH - *Health Surveys PMC - PMC11840296 OTO - NOTNLM OT - Artificial Neural Networks OT - Children OT - Feature importance OT - Rwanda. OT - Stunting COIS- No competing interests were disclosed. EDAT- 2025/02/21 11:09 MHDA- 2025/02/21 11:10 PMCR- 2025/01/20 CRDT- 2025/02/21 04:53 PHST- 2025/01/06 00:00 [accepted] PHST- 2025/02/21 11:10 [medline] PHST- 2025/02/21 11:09 [pubmed] PHST- 2025/02/21 04:53 [entrez] PHST- 2025/01/20 00:00 [pmc-release] AID - 10.12688/f1000research.141458.2 [doi] PST - epublish SO - F1000Res. 2025 Jan 20;13:128. doi: 10.12688/f1000research.141458.2. eCollection 2024. PMID- 39980978 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250222 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 16 DP - 2025 TI - Investigating the relationship between inflammatory cytokines and adolescent depression: a comparative analysis. PG - 1524015 LID - 10.3389/fpsyt.2025.1524015 [doi] LID - 1524015 AB - BACKGROUND: Major depressive disorder (MDD) in adolescents poses a significant threat to physical health. Previous studies have indicated that adolescents with MDD exhibit immune activation. OBJECTIVE: This study aimed to compare cytokine levels in adolescents with MDD to healthy controls and assess their diagnostic value. METHODS: This cross-sectional study included 58 adolescent patients with depression from Beijing Anding Hospital (outpatients and inpatients) and 40 healthy adolescents recruited from the community. Multiplex cytokine analysis (Luminex xMAP) was used to measure serum levels of several cytokines. Data analysis was performed using SPSS (version 26.0) to compare cytokine levels between adolescents with MDD and healthy controls and assess gender differences. Correlations between cytokine levels and demographic data, clinical features and depressive symptoms were also analyzed. The receiver operating characteristic (ROC) curves were used to evaluate the diagnostic value of cytokines. RESULTS: Serum IL-4, IFN-gamma, and TNF-alpha levels were significantly elevated in MDD group compared with healthy controls (p < 0.05). In MDD group, the age of first onset of depression in females was significantly younger than that in males (p < 0.05), and female serum TNF-alpha levels were significantly higher than those in males (p < 0.05). BMI and serum IL-4 levels were significantly positively correlated in adolescents with MDD. The area under the ROC curve for serum IL-4 and TNF-alpha in diagnosing adolescent depression was 0.695 (95% confidence interval [CI]: 0.580 - 0.809; p < 0.05), with a sensitivity of 0.793 and specificity of 0.675. CONCLUSION: Compared with healthy controls, adolescents with depression demonstrated significantly elevated serum cytokine levels, indicating immune activation which were higher in female. Cytokines may have promising diagnostic value in adolescent depression, but further validation with additional indicators is needed. CI - Copyright (c) 2025 Liu, Tang, Xu, Chen, Fang, He and Zheng. FAU - Liu, Mengqi AU - Liu M AD - The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China. AD - Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China. FAU - Tang, Jie AU - Tang J AD - The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China. AD - Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China. FAU - Xu, Gaoyang AU - Xu G AD - The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China. AD - Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China. FAU - Chen, Xu AU - Chen X AD - The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China. AD - Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China. FAU - Fang, Kun AU - Fang K AD - School of Basic Medical Sciences, Capital Medical University, Beijing, China. FAU - He, Fan AU - He F AD - The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China. AD - Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China. FAU - Zheng, Yi AU - Zheng Y AD - The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China. AD - Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China. LA - eng PT - Journal Article DEP - 20250206 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC11839723 OTO - NOTNLM OT - IL-4 OT - TNF-alpha OT - adolescents OT - depression OT - inflammation COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/02/21 11:09 MHDA- 2025/02/21 11:10 PMCR- 2025/02/06 CRDT- 2025/02/21 04:51 PHST- 2024/11/06 00:00 [received] PHST- 2025/01/15 00:00 [accepted] PHST- 2025/02/21 11:10 [medline] PHST- 2025/02/21 11:09 [pubmed] PHST- 2025/02/21 04:51 [entrez] PHST- 2025/02/06 00:00 [pmc-release] AID - 10.3389/fpsyt.2025.1524015 [doi] PST - epublish SO - Front Psychiatry. 2025 Feb 6;16:1524015. doi: 10.3389/fpsyt.2025.1524015. eCollection 2025. PMID- 39978359 OWN - NLM STAT- MEDLINE DCOM- 20250324 LR - 20250516 IS - 1555-0273 (Electronic) IS - 1555-0265 (Linking) VI - 20 IP - 4 DP - 2025 Apr 1 TI - Validity and Sensitivity of a Submaximal Fitness Test for Assessing Cardiorespiratory Fitness and Response to Preseason Training Load in Female Football Players. PG - 592-599 LID - 10.1123/ijspp.2024-0376 [doi] AB - PURPOSE: To evaluate the within-athlete sensitivity, validity, and dose-response relationships of exercise heart rate (HRex) from a submaximal fitness test (SMFT) as a proxy measure of cardiorespiratory fitness. METHODS: This study follows an observational, repeated-measures design. Twenty-five trained female football players' training loads (GPS and HR metrics) were collected throughout an 8-week preseason period. A 4-minute continuous-fixed SMFT protocol was administered weekly to evaluate HRex. A running time-trial assessment was conducted in weeks 2 and 8 to calculate mean velocity (5-min-30-s time-trial mean velocity) as a proxy measure of cardiorespiratory fitness. SMFT HRex measurement properties were determined via within- and between-athletes correlations and linear mixed models. RESULTS: The overall preseason change in SMFT HRex derived from weekly repeated measures was -4.7% points (90% CIs, -3.9 to -5.6). The association between SMFT HRex and 5-minute-30-second time-trial mean velocity changes was large (-0.55), with 90% CIs ranging from negative moderate to negative very large magnitudes (-0.31 to -0.71). A 1% point decrease in SMFT HRex corresponded to an increase in 5-minute-30-second time-trial mean velocity of 0.13 (90% CIs, 0.03-0.24) km.h-1. Within-athlete correlations between training loads and SMFT HRex demonstrated moderate inverse relationships with external-load parameters (-0.39 to -0.47) and small inverse relationships with HR-based internal metrics (-0.25 to -0.29). Accumulated high- and very high-speed running throughout the entire preseason showed consistent inverse dose-response relationships with SMFT HRex (moderate and large, respectively), while all other load measures displayed unclear associations. CONCLUSIONS: SMFT HRex is a sensitive and valid tool to evaluate preseason cardiorespiratory-fitness changes in female football players. FAU - MacKenzie, Lachlan AU - MacKenzie L AUID- ORCID: 0009-0008-9163-1508 AD - Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, Australia. FAU - Lovell, Ric AU - Lovell R AUID- ORCID: 0000-0001-5859-0267 AD - Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, Australia. FAU - Atkinson, Lana AU - Atkinson L AUID- ORCID: 0009-0008-4860-7748 AD - Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, Australia. FAU - Naumovski, Daniel AU - Naumovski D AD - South Coast Flame Football Club, Wollongong, NSW, Australia. FAU - Shushan, Tzlil AU - Shushan T AUID- ORCID: 0000-0002-0544-1986 AD - Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, Australia. LA - eng PT - Journal Article PT - Observational Study PT - Validation Study DEP - 20250220 PL - United States TA - Int J Sports Physiol Perform JT - International journal of sports physiology and performance JID - 101276430 SB - IM MH - Humans MH - *Cardiorespiratory Fitness/physiology MH - Female MH - *Exercise Test/methods MH - Heart Rate/physiology MH - *Soccer/physiology MH - *Physical Conditioning, Human/methods MH - Young Adult MH - Running/physiology MH - Reproducibility of Results MH - Adult MH - Adolescent MH - Sensitivity and Specificity OTO - NOTNLM OT - dose-response OT - heart rate OT - invisible monitoring OT - soccer OT - within-athlete OT - women EDAT- 2025/02/21 00:21 MHDA- 2025/03/24 18:30 CRDT- 2025/02/20 18:43 PHST- 2024/09/10 00:00 [received] PHST- 2024/12/12 00:00 [revised] PHST- 2025/01/06 00:00 [accepted] PHST- 2025/03/24 18:30 [medline] PHST- 2025/02/21 00:21 [pubmed] PHST- 2025/02/20 18:43 [entrez] AID - 10.1123/ijspp.2024-0376 [doi] PST - epublish SO - Int J Sports Physiol Perform. 2025 Feb 20;20(4):592-599. doi: 10.1123/ijspp.2024-0376. Print 2025 Apr 1. PMID- 39977190 OWN - NLM STAT- MEDLINE DCOM- 20250509 LR - 20250509 IS - 1606-7916 (Electronic) IS - 0036-3634 (Linking) VI - 67 IP - 1 (ene-feb) DP - 2024 Nov 27 TI - Functional food consumption preference in Culiacan, Mexico. PG - 28-38 LID - 10.21149/15741 [doi] AB - OBJECTIVE: To determine functional food consumption preferences in Culiacan, Mexico. MATERIALS AND METHODS: A survey was designed, validated, and implemented to gather information on functional food consumption. Associations between health conditions and functional food consumption were evaluated. Using the Borda count methodology, the preference order of different functional foods was identified, seeking statistical differences between preferences. RESULTS: A validated questionnaire was obtained for the survey application. Association was found between having a diagnosed illness, undergoing medical treatment, and sex with awareness of functional foods; however, no association was observed between having a diagnosed illness and potential functional food consumption. The top three preferred foods were beverages, bars, and yogurt, with taste being the most important characteristic for functional food consumption. CONCLUSIONS: There is low consumption of functional foods, which may be associated with various factors. In designing and developing functional foods, it is important to consider preferences such as beverages, bars, and yogurts, emphasizing consumer taste acceptance. FAU - Lopez-Cardoso, Fernando AU - Lopez-Cardoso F AD - Departamento de Ciencia y Tecnologia de Alimentos, Centro de Investigacion en Alimentacion y Desarrollo AC. Culiacan, Sinaloa, Mexico.. flopez222@estudiantes.ciad.mx. FAU - Ontiveros-Apodaca, Noe AU - Ontiveros-Apodaca N AD - Departamento de Ciencias Quimico-Biologicas y Agropecuarias, Universidad de Sonora. Navojoa, Sonora, Mexico.. noe.ontiveros@unison.mx. FAU - Gutierrez-Grijalva, Erick Paul AU - Gutierrez-Grijalva EP AD - Departamento de Ciencia y Tecnologia de Alimentos, Centro de Investigacion en Alimentacion y Desarrollo AC. Culiacan, Sinaloa, Mexico.. erick.gutierrez@ciad.mx. FAU - Aramburo-Galvez, Jesus Gilberto AU - Aramburo-Galvez JG AD - Facultad de Ciencias de la Nutricion y Gastronomia, Universidad Autonoma de Sinaloa. Culiacan, Sinaloa, Mexico.. gilberto.aramburo.g@gmail.com. FAU - Figueroa-Salcido, Oscar Gerardo AU - Figueroa-Salcido OG AD - Facultad de Ciencias de la Nutricion y Gastronomia, Universidad Autonoma de Sinaloa. Culiacan, Sinaloa, Mexico.. oscar.figueroa@uas.edu.mx. FAU - Leyva-Lopez, Nayely AU - Leyva-Lopez N AD - Departamento de Ciencia y Tecnologia de Alimentos, Centro de Investigacion en Alimentacion y Desarrollo AC. Culiacan, Sinaloa, Mexico.. nayely.leyva@ciad.mx. FAU - Gastelum-Chavira, Diego A AU - Gastelum-Chavira DA AD - Departamento de Ciencias Economico-Administrativas, Universidad Autonoma de Occidente. Culiacan, Sinaloa, Mexico.. chaviradiego@hotmail.com. FAU - Cardenas-Torres, Feliznando Isidro AU - Cardenas-Torres FI AD - Posgrado en Ciencias de la Nutricion y Alimentos Medicinales, Universidad Autonoma de Sinaloa. Culiacan, Sinaloa, Mexico.. feliznando@uas.edu.mx. FAU - Heredia, J Basilio AU - Heredia JB AD - Departamento de Ciencia y Tecnologia de Alimentos, Centro de Investigacion en Alimentacion y Desarrollo AC. Culiacan, Sinaloa, Mexico.. jbheredia@ciad.mx. LA - eng PT - Journal Article DEP - 20241127 PL - Mexico TA - Salud Publica Mex JT - Salud publica de Mexico JID - 0404371 SB - IM MH - Mexico MH - Humans MH - Male MH - Female MH - *Food Preferences MH - Adult MH - *Functional Food/statistics & numerical data MH - Middle Aged MH - Young Adult MH - Adolescent MH - Surveys and Questionnaires MH - Aged MH - Cross-Sectional Studies EDAT- 2025/02/20 18:21 MHDA- 2025/02/20 18:22 CRDT- 2025/02/20 12:08 PHST- 2024/03/06 00:00 [received] PHST- 2024/10/04 00:00 [accepted] PHST- 2025/02/20 18:22 [medline] PHST- 2025/02/20 18:21 [pubmed] PHST- 2025/02/20 12:08 [entrez] AID - 10.21149/15741 [doi] PST - epublish SO - Salud Publica Mex. 2024 Nov 27;67(1 (ene-feb)):28-38. doi: 10.21149/15741. PMID- 39974824 OWN - NLM STAT- MEDLINE DCOM- 20250509 LR - 20250509 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 16 DP - 2025 TI - Magnetic resonance imaging -based radiomics of the pituitary gland is highly predictive of precocious puberty in girls: a pilot study. PG - 1496554 LID - 10.3389/fendo.2025.1496554 [doi] LID - 1496554 AB - BACKGROUND: The aim of the study was to explore a radiomic model that could assist physicians in the diagnosis of central precocious puberty (CPP). A predictive model based on radiomic features (RFs), extracted form magnetic resonance imaging (MRI) of the pituitary gland, was thus developed to distinguish between CPP and control subjects. METHODS: 45 girls with confirmed diagnosis of CPP (CA:8.4 +/- 0.9 yr) according to the current criteria and 47 age-matched pre-pubertal control subjects (CA:8.7 +/- 1.2 yr) were retrospectively enrolled. Two readers (R1, R2) blindly segmented the pituitary gland on MRI studies for RFs and performed a manual estimation of the pituitary volume. Radiomics was compared against pituitary volume in terms of predictive performances (metrics: ROC-AUC, accuracy, sensitivity and specificity) and reliability (metric: intraclass correlation coefficient, ICC). Pearson correlation between RFs and auxological, biochemical, and ultrasound data was also computed. RESULTS: Two different radiomic parameters, Shape Surface Volume Ratio and Glrlm Gray Level Non-Uniformity, predicted CPP with a high diagnostic accuracy (ROC-AUC 0.81 +/- 0.08) through the application of our ML algorithm. Anthropometric variables were not confounding factors of these RFs suggesting that premature thelarche and/or pubarche would not be potentially misclassified. The selected RFs correlated with baseline and peak LH (p < 0.05) after GnRH stimulation. The diagnostic sensitivity was improved compared to pituitary volume only (0.76 versus 0.68, p<0.001) and demonstrated higher inter-reader reliability (ICC>0.57 versus ICC=0.46). DISCUSSION: Radiomics is a promising tool to diagnose CPP as it reflects also functional aspects. Further studies are warranted to validate these preliminary data. CI - Copyright (c) 2025 Maddalo, Petraroli, Ormitti, Fulgoni, Gnocchi, Masetti, Borgia, Piccolo, Turco, Patianna, Sverzellati, Esposito, Ghetti and Street. FAU - Maddalo, Michele AU - Maddalo M AD - Medical Physics Department, University Hospital of Parma, Parma, Italy. FAU - Petraroli, Maddalena AU - Petraroli M AD - Unit of Pediatrics, Department of Mother and Child, University Hospital of Parma, Parma, Italy. FAU - Ormitti, Francesca AU - Ormitti F AD - Neuroradiology Unit, University Hospital of Parma, Parma, Italy. FAU - Fulgoni, Alice AU - Fulgoni A AD - Department of Medicine and Surgery, University of Parma, Parma, Italy. FAU - Gnocchi, Margherita AU - Gnocchi M AD - Department of Medicine and Surgery, University of Parma, Parma, Italy. FAU - Masetti, Marco AU - Masetti M AD - Department of Medicine and Surgery, University of Parma, Parma, Italy. FAU - Borgia, Eugenia AU - Borgia E AD - Department of Medicine and Surgery, University of Parma, Parma, Italy. FAU - Piccolo, Benedetta AU - Piccolo B AD - Unit of Pediatrics, Department of Mother and Child, University Hospital of Parma, Parma, Italy. FAU - Turco, Emanuela C AU - Turco EC AD - Unit of Pediatrics, Department of Mother and Child, University Hospital of Parma, Parma, Italy. FAU - Patianna, Viviana D AU - Patianna VD AD - Unit of Pediatrics, Department of Mother and Child, University Hospital of Parma, Parma, Italy. FAU - Sverzellati, Nicola AU - Sverzellati N AD - Department of Medicine and Surgery, University of Parma, Parma, Italy. FAU - Esposito, Susanna AU - Esposito S AD - Unit of Pediatrics, Department of Mother and Child, University Hospital of Parma, Parma, Italy. AD - Department of Medicine and Surgery, University of Parma, Parma, Italy. FAU - Ghetti, Caterina AU - Ghetti C AD - Medical Physics Department, University Hospital of Parma, Parma, Italy. FAU - Street, Maria E AU - Street ME AD - Unit of Pediatrics, Department of Mother and Child, University Hospital of Parma, Parma, Italy. AD - Department of Medicine and Surgery, University of Parma, Parma, Italy. LA - eng PT - Journal Article DEP - 20250205 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - *Puberty, Precocious/diagnostic imaging/diagnosis MH - Female MH - *Pituitary Gland/diagnostic imaging/pathology MH - Child MH - Pilot Projects MH - *Magnetic Resonance Imaging/methods MH - Retrospective Studies MH - Predictive Value of Tests MH - Radiomics PMC - PMC11835667 OTO - NOTNLM OT - central precocious puberty OT - machine learning OT - magnetic resonance imaging OT - pituitary gland OT - precocious puberty, puberty OT - radiomics COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2025/02/20 06:21 MHDA- 2025/02/20 06:22 PMCR- 2025/01/01 CRDT- 2025/02/20 05:34 PHST- 2024/09/14 00:00 [received] PHST- 2025/01/15 00:00 [accepted] PHST- 2025/02/20 06:22 [medline] PHST- 2025/02/20 06:21 [pubmed] PHST- 2025/02/20 05:34 [entrez] PHST- 2025/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2025.1496554 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2025 Feb 5;16:1496554. doi: 10.3389/fendo.2025.1496554. eCollection 2025. PMID- 39973209 OWN - NLM STAT- MEDLINE DCOM- 20250708 LR - 20260720 IS - 1469-8749 (Electronic) IS - 0012-1622 (Linking) VI - 67 IP - 8 DP - 2025 Aug TI - Eating and drinking abilities and respiratory and oral health in children and young adults with cerebral palsy. PG - 1075-1084 LID - 10.1111/dmcn.16262 [doi] AB - AIM: To investigate the potential risk factors of respiratory illness (ethnicity, oral health, and eating and drinking ability) in children and young adults with cerebral palsy (CP). METHOD: This was an observational study using a validated CP Respiratory and Oral Health questionnaire with 90 participants (median age 12 years [range: 1-26 years]; 51 males; and 26 New Zealand Maori). RESULTS: Multivariate analysis, accounting for ethnicity and Gross Motor Function Classification System (GMFCS) levels, showed that those participants who were classified in Eating and Drinking Ability Classification System (EDACS) levels III to V reported more previous respiratory disease episodes (odds ratio [OR] = 4.13, 95% confidence interval [CI] = 1.12-15.2, p = 0.033), increased daily/weekly respiratory symptoms (OR = 9.14, 95% CI = 2.03-41.2, p = 0.004), and increased mealtime respiratory symptoms (OR = 13.8, 95% CI = 2.48-76.8, p = 0.002). Both EDACS levels III to V and GMFCS levels IV and V were independently associated with increased propensity to reflux or seizures (OR = 8.16, 95% CI = 1.77-37.5, p = 0.007; OR = 3.37, 95% CI = 1.09-10.4, p < 0.034). Mealtime symptoms of vomiting or regurgitation (relative risk = 1.58, 95% CI = 1.17-2.13, p = 0.032) and daily coughing (relative risk = 1.55, 95% CI = 1.14-2.11, p = 0.023) were associated with a higher risk of reporting one or more oral health symptoms. Toothache was more common in participants classified in EDACS levels III to V (chi(2), p = 0.021). INTERPRETATION: Children with CP classified in EDACS levels III to V are at a higher risk of respiratory disease and toothache and should be screened appropriately. Regurgitation or vomiting of food and daily coughing are linked with poorer oral health. CI - (c) 2025 Mac Keith Press. FAU - Sorhage, Alexandra AU - Sorhage A AUID- ORCID: 0000-0001-6716-5545 AD - Paediatric Orthopaedics, Starship Children's Health, Auckland, New Zealand. FAU - Blackmore, A Marie AU - Blackmore AM AUID- ORCID: 0000-0002-5824-9402 AD - Telethon Kids Institute, Perth, WA, Australia. AD - Centre for Child Health Research, The University of Western Australia, Perth, WA, Australia. FAU - Byrnes, Catherine A AU - Byrnes CA AD - Paediatric Respiratory Services, Starship Children's Health, Auckland, New Zealand. AD - Department of Paediatrics, University of Auckland, Auckland, New Zealand. FAU - Agnew, Caitlin AU - Agnew C AD - Hospital & Specialist Dentistry Regional Service, Auckland, New Zealand. FAU - Webster, Emily F M AU - Webster EFM AD - Kidz First Children's Hospital, Counties Manukau Health, Auckland, New Zealand. FAU - Mackey, Anna AU - Mackey A AD - Paediatric Orthopaedics, Starship Children's Health, Auckland, New Zealand. FAU - Chong, Jimmy AU - Chong J AD - Paediatric Rehabilitation, Starship Children's Health, Auckland, New Zealand. FAU - Hill, Timothy M AU - Hill TM AD - Kidz First Children's Hospital, Counties Manukau Health, Auckland, New Zealand. FAU - Han, Dug Yeo AU - Han DY AD - Starship Research and Innovation, Starship Children's Health, Auckland, New Zealand. FAU - Stott, Ngaire Susan AU - Stott NS AD - Paediatric Orthopaedics, Starship Children's Health, Auckland, New Zealand. AD - Department of Surgery, University of Auckland, Auckland, New Zealand. LA - eng GR - SF2143;A+8974/Starship Foundation/ PT - Journal Article PT - Observational Study DEP - 20250220 PL - England TA - Dev Med Child Neurol JT - Developmental medicine and child neurology JID - 0006761 SB - IM MH - Humans MH - *Cerebral Palsy/complications/physiopathology/epidemiology MH - Male MH - Child MH - Female MH - *Oral Health MH - Adolescent MH - Young Adult MH - Child, Preschool MH - Adult MH - Infant MH - *Eating/physiology MH - New Zealand MH - *Drinking/physiology MH - Surveys and Questionnaires MH - Risk Factors MH - *Respiration Disorders/etiology EDAT- 2025/02/20 06:22 MHDA- 2025/07/08 18:26 CRDT- 2025/02/20 03:22 PHST- 2025/01/09 00:00 [revised] PHST- 2024/07/02 00:00 [received] PHST- 2025/01/15 00:00 [accepted] PHST- 2025/07/08 18:26 [medline] PHST- 2025/02/20 06:22 [pubmed] PHST- 2025/02/20 03:22 [entrez] AID - 10.1111/dmcn.16262 [doi] PST - ppublish SO - Dev Med Child Neurol. 2025 Aug;67(8):1075-1084. doi: 10.1111/dmcn.16262. Epub 2025 Feb 20. PMID- 39973171 OWN - NLM STAT- MEDLINE DCOM- 20250414 LR - 20250416 IS - 2153-2176 (Electronic) IS - 2153-2168 (Linking) VI - 21 IP - 3 DP - 2025 Apr TI - Development and Testing of the Observational System for Recording Physical Activity in Children-Toddlers. PG - 356-364 LID - 10.1089/chi.2024.0376 [doi] AB - Background: Direct observation (DO) tools developed for preschoolers have been used to describe toddler physical activity (PA). No DO system created to assess PA levels and the childcare environment of toddlers exists. The purpose of this study was to develop the Observational System for Recording Physical Activity in Children-Toddlers (OSRAC-T) and assess the inter- and intra-rater reliability. Methods: This tool is an extension of the Observational System for Recording Physical Activity in Children-Preschool and uses the same focal child, time sampling system (5-second observation and 25-second recording). Tool content was established through identifying similar research, consulting with experts, and conducting informal observations. A sample of toddlers (12-36 months) was observed and video recorded during childcare. In-person observations were compared to video observations from one coder (intrarater reliability). Video observations (39% of intervals) were coded by two raters to determine interrater reliability. Results: The final instrument included nine categories that described PA level and type, social and environmental contexts, and transition support relevant to toddlers. Observers completed 124 observation sessions (n = 31; 25.5 +/- 6.0 months) resulting in 7,757 30-second observation intervals. Interval-by-interval agreement was moderate to high (58.90%-95.30%) for all categories, and interrater reliability was low to moderate (k = 0.28-0.69). Conclusion: The OSRAC-T is a reliable observation system to assess several PA-related behaviors of toddlers. It may be used to better inform early childcare center design, future intervention studies, or to assess correlates or relationships between PA behavior and health outcomes in toddlers. FAU - Van Camp, Cailyn A AU - Van Camp CA AUID- ORCID: 0009-0008-6143-1425 AD - Department of Kinesiology, Michigan State University, East Lansing, MI, USA. FAU - Panlasigue, Anela AU - Panlasigue A AD - Department of Kinesiology, Michigan State University, East Lansing, MI, USA. FAU - Clevenger, Kimberly A AU - Clevenger KA AD - Department of Kinesiology and Health Science, Utah State University, Logan, UT, USA. FAU - Hauck, Janet L AU - Hauck JL AD - Department of Kinesiology, Michigan State University, East Lansing, MI, USA. FAU - McIver, Kerry L AU - McIver KL AD - Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. FAU - Pfeiffer, Karin A AU - Pfeiffer KA AD - Department of Kinesiology, Michigan State University, East Lansing, MI, USA. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20250220 PL - United States TA - Child Obes JT - Childhood obesity (Print) JID - 101542497 SB - IM MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - *Behavior Observation Techniques/methods MH - Child Behavior MH - Child Day Care Centers MH - *Exercise MH - Observation MH - Observer Variation MH - Reproducibility of Results MH - Video Recording OTO - NOTNLM OT - direct observation OT - physical activity OT - reliability OT - toddler EDAT- 2025/02/20 06:22 MHDA- 2025/04/14 18:24 CRDT- 2025/02/20 03:13 PHST- 2025/04/14 18:24 [medline] PHST- 2025/02/20 06:22 [pubmed] PHST- 2025/02/20 03:13 [entrez] AID - 10.1089/chi.2024.0376 [doi] PST - ppublish SO - Child Obes. 2025 Apr;21(3):356-364. doi: 10.1089/chi.2024.0376. Epub 2025 Feb 20. PMID- 39972963 OWN - NLM STAT- MEDLINE DCOM- 20250508 LR - 20260910 IS - 2190-6009 (Electronic) IS - 2190-5991 (Print) IS - 2190-5991 (Linking) VI - 16 IP - 1 DP - 2025 Feb TI - Leg Muscle Volume, Intramuscular Fat and Force Generation: Insights From a Computer-Vision Model and Fat-Water MRI. PG - e13735 LID - 10.1002/jcsm.13735 [doi] LID - e13735 AB - BACKGROUND: Maintaining skeletal muscle health (i.e., muscle size and quality) is crucial for preserving mobility. Decreases in lower limb muscle volume and increased intramuscular fat (IMF) are common findings in people with impaired mobility. We developed an automated method to extract markers of leg muscle health, muscle volume and IMF, from MRI. We then explored their associations with age, body mass index (BMI), sex and voluntary force generation. METHODS: We trained (n = 34) and tested (n = 16) a convolutional neural network (CNN) to segment five muscle groups in both legs from fat-water MRI to explore muscle volume and IMF. In 95 participants (70 females, 25 males, mean age [standard deviation] = 34.2 (11.2) years, age range = 18-60 years), we explored associations between the CNN measures and age, BMI and sex, and then in a subset of 75 participants, we explored associations between CNN muscle volume, CNN IMF and maximum plantarflexion force after controlling for age, BMI and sex. RESULTS: The CNN demonstrated high test accuracy (Sorensen-Dice index >/= 0.87 for all muscle groups) and reliability (muscle volume ICC(2,1) >/= 0.923 and IMF ICC(2),(1) >/= 0.815 for all muscle groups) compared to manual segmentation. CNN muscle volume was positively associated with BMI across all muscle groups (p /= 0.406). CNN IMF was positively associated with age for all muscle groups (p /= 0.067). Gastrocnemius CNN IMF was greater in females (p /= 0.358). CONCLUSIONS: Computer-vision models combined with fat-water MRI permits the non-invasive, automatic assessment of leg muscle volume and IMF. Associations with age, BMI and sex are important when interpreting these measures. Markers of leg muscle health may enhance our understanding of the relationship between muscle health, force generation and mobility. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT02157038. CI - (c) 2025 The Author(s). Journal of Cachexia, Sarcopenia and Muscle published by Wiley Periodicals LLC. FAU - Smith, Andrew C AU - Smith AC AD - Physical Therapy Program, Department of Physical Medicine and Rehabilitation, School of Medicine, University of Colorado, Aurora, Colorado, USA. FAU - Laguna, Javier Munoz AU - Laguna JM AD - EBPI-UWZH Musculoskeletal Epidemiology Research Group, University of Zurich and Balgrist University Hospital, Zurich, Switzerland. AD - Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich, Zurich, Switzerland. AD - University Spine Centre Zurich (UWZH), Balgrist University Hospital and University of Zurich, Zurich, Switzerland. FAU - Wesselink, Eddo O AU - Wesselink EO AD - Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. AD - Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, California, USA. FAU - Scott, Zachary E AU - Scott ZE AD - Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, California, USA. AD - Rehabilitation Care Services, VA Puget Sound Health Care System, Tacoma, Washington, USA. FAU - Jenkins, Hazel AU - Jenkins H AD - Department of Chiropractic, Macquarie University, Sydney, New South Wales, Australia. FAU - Thornton, Wesley A AU - Thornton WA AD - Physical Therapy Program, Department of Physical Medicine and Rehabilitation, School of Medicine, University of Colorado, Aurora, Colorado, USA. FAU - Wasielewski, Marie AU - Wasielewski M AD - Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. FAU - Connor, Jordan AU - Connor J AD - Physical Therapy Program, Department of Physical Medicine and Rehabilitation, School of Medicine, University of Colorado, Aurora, Colorado, USA. FAU - Delp, Scott AU - Delp S AD - Department of Bioengineering and Mechanical Engineering, Stanford University, Palo Alto, California, USA. FAU - Chaudhari, Akshay S AU - Chaudhari AS AD - Department of Radiology, Stanford University School of Medicine, Palo Alto, California, USA. FAU - Parrish, Todd B AU - Parrish TB AD - Department of Radiology, Northwestern University, Chicago, Illinois, USA. FAU - Mackey, Sean AU - Mackey S AD - Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, California, USA. FAU - Elliott, James M AU - Elliott JM AD - Northern Sydney Local Health District, The Kolling Institute, St. Leonards, New South Wales, Australia. AD - The Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia. FAU - Weber, Kenneth A 2nd AU - Weber KA 2nd AUID- ORCID: 0000-0002-0916-9174 AD - Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, California, USA. LA - eng SI - ClinicalTrials.gov/NCT02157038 GR - R01 EB002524/EB/NIBIB NIH HHS/United States GR - R01AR079431/AR/NIAMS NIH HHS/United States GR - R01NS128478/NS/NINDS NIH HHS/United States GR - R01 AR079431/AR/NIAMS NIH HHS/United States GR - R01 AR077604/AR/NIAMS NIH HHS/United States GR - R01AR077604/AR/NIAMS NIH HHS/United States GR - L30 NS108301/NS/NINDS NIH HHS/United States GR - K24 NS126781/NS/NINDS NIH HHS/United States GR - P41EB027060/EB/NIBIB NIH HHS/United States GR - K01HD106928/National Institute of Child Health and Human Development/National Center for Medical Rehabilitation Research/ GR - R01EB002524/EB/NIBIB NIH HHS/United States GR - L30NS108301/NS/NINDS NIH HHS/United States GR - R01 HD079076/HD/NICHD NIH HHS/United States GR - K23 NS104211/NS/NINDS NIH HHS/United States GR - K01 HD106928/HD/NICHD NIH HHS/United States GR - P41 EB027060/EB/NIBIB NIH HHS/United States GR - R01 NS128478/NS/NINDS NIH HHS/United States GR - K24NS126781/NS/NINDS NIH HHS/United States GR - K23NS104211/NS/NINDS NIH HHS/United States GR - R01HD079076/National Institute of Child Health and Human Development/National Center for Medical Rehabilitation Research/ GR - Boettcher Foundation's Webb-Waring Biomedical Research Program/ PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. PL - Germany TA - J Cachexia Sarcopenia Muscle JT - Journal of cachexia, sarcopenia and muscle JID - 101552883 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - *Adipose Tissue/diagnostic imaging MH - Body Mass Index MH - *Leg/diagnostic imaging MH - *Magnetic Resonance Imaging/methods MH - *Muscle, Skeletal/diagnostic imaging/physiology/anatomy & histology MH - *Convolutional Neural Networks MH - Software Validation PMC - PMC11839747 OTO - NOTNLM OT - computer-assisted OT - image processing OT - leg OT - magnetic resonance imaging OT - muscle strength OT - rehabilitation COIS- James M. Elliott has a 3% interest in Orofacial Therapeutics, LLC and receives royalties (< USD$10 000 annually) for online educational courses regarding trauma informed care and whiplash associated disorders. Akshay S. Chaudhari has provided consulting services to Patient Square Capital and Elucid Bioimaging; has ownership interests in Subtle Medical, Brain Key and LVIS Corp; and receives research support from GE Healthcare, Philips, Amazon, Microsoft and Stability.ai. The information provided in this study are unrelated to those perceived conflicts of interest. All remaining authors declare no conflicts of interest. EDAT- 2025/02/20 06:22 MHDA- 2025/02/20 06:23 PMCR- 2025/02/19 CRDT- 2025/02/20 01:13 PHST- 2025/01/06 00:00 [revised] PHST- 2024/08/28 00:00 [received] PHST- 2025/01/12 00:00 [accepted] PHST- 2025/02/20 06:23 [medline] PHST- 2025/02/20 06:22 [pubmed] PHST- 2025/02/20 01:13 [entrez] PHST- 2025/02/19 00:00 [pmc-release] AID - JCSM13735 [pii] AID - 10.1002/jcsm.13735 [doi] PST - ppublish SO - J Cachexia Sarcopenia Muscle. 2025 Feb;16(1):e13735. doi: 10.1002/jcsm.13735. PMID- 39972936 OWN - NLM STAT- MEDLINE DCOM- 20250228 LR - 20250228 IS - 2162-3279 (Electronic) VI - 15 IP - 2 DP - 2025 Feb TI - Evaluation of the reliability and internal consistency of the child eating behavior questionnaire (CEBQ) in spanish schoolchildren and its association with obesity. PG - e70343 LID - 10.1002/brb3.70343 [doi] LID - e70343 AB - INTRODUCTION: Certain behavioral traits increase the risk of obesity at early ages. Exploring patterns of eating behavior in schoolchildren using tools like the Children's Eating Behavior Questionnaire (CEBQ) is crucial for obesity prevention and intervention. Before this study, the CEBQ had been validated in various languages, including Spanish, but only in preschool-aged children, despite its previous use in various studies in the Spanish language and population. The objective is to assess the reliability and internal consistency of the CEBQ questionnaire applied to a sample of Spanish schoolchildren and to explore the association between eating behavior assessed through the CEBQ and nutritional status based on BMI. METHODS: Parents or guardians of 283 Spanish schoolchildren aged 6-16 years completed the Spanish version of the CEBQ questionnaire. Factor analyses were conducted on all CEBQ items, and differences between genders and age groups were examined. Correlations between children's BMI Z-scores and eating behaviors were analyzed through linear regression. RESULTS: The factor analysis revealed that the CEBQ is suitable in its original structure of eight subscales translated into Spanish, demonstrating adequate reliability and acceptable correlations between subscales. Gender appears to have minimal influence on eating behavior. However, with increasing age, schoolchildren tend to eat more quickly and are less fussy about food (SE [slowness in eating] [p = 0.012] and FF [food fussiness] [p = 0.012] decrease). Positive associations were found between BMI Z-scores and all pro-eating dimension subscales, while negative associations were identified with all antieating dimension subscales (p < 0.05) except EUE (emotional undereating) (p = 0.106). CONCLUSIONS: The CEBQ is a valid psychometric tool that can be reliably used to assess eating behavior characteristics in Spanish schoolchildren aged 6-16 years. CI - (c) 2025 The Author(s). Brain and Behavior published by Wiley Periodicals LLC. FAU - Garcia, Andrea Calderon AU - Garcia AC AUID- ORCID: 0000-0001-8257-8532 AD - Research Group EPINUT (Nutritional Epidemiology) Faculty of Medicine, Complutense University of Madrid, Madrid, Spain. AD - Department of Pharmacy and Nutrition, Faculty of Biomedical Sciences, European University of Madrid, UEM, Villaviciosa de Odon, Madrid, Spain. FAU - Pedrero-Tome, Roberto AU - Pedrero-Tome R AUID- ORCID: 0000-0003-0318-2981 AD - Research Group EPINUT (Nutritional Epidemiology) Faculty of Medicine, Complutense University of Madrid, Madrid, Spain. AD - Department of Biodiversity, Ecology and Evolution, Faculty of Biology, Complutense University of Madrid, Madrid, Spain. FAU - Alaminos-Torres, Ana AU - Alaminos-Torres A AD - Research Group EPINUT (Nutritional Epidemiology) Faculty of Medicine, Complutense University of Madrid, Madrid, Spain. AD - Department of Biodiversity, Ecology and Evolution, Faculty of Biology, Complutense University of Madrid, Madrid, Spain. FAU - Lopez-Ejeda, Noemi AU - Lopez-Ejeda N AUID- ORCID: 0000-0003-1310-0134 AD - Research Group EPINUT (Nutritional Epidemiology) Faculty of Medicine, Complutense University of Madrid, Madrid, Spain. AD - Department of Biodiversity, Ecology and Evolution, Faculty of Biology, Complutense University of Madrid, Madrid, Spain. FAU - Sanchez Alvarez, Maria AU - Sanchez Alvarez M AUID- ORCID: 0000-0003-3049-3822 AD - Research Group EPINUT (Nutritional Epidemiology) Faculty of Medicine, Complutense University of Madrid, Madrid, Spain. AD - Faculty of Health Sciences and Faculty of Humanities and Social Sciences of the International University Isabel I of Burgos, Burgos, Spain. FAU - Martinez, Consuelo Prado AU - Martinez CP AUID- ORCID: 0000-0002-8995-4999 AD - Research Group EPINUT (Nutritional Epidemiology) Faculty of Medicine, Complutense University of Madrid, Madrid, Spain. AD - Department of Biology, Faculty of Sciences, Universidad Autonoma de Madrid, Madrid, Spain. FAU - Martinez Alvarez, Jesus Roman AU - Martinez Alvarez JR AUID- ORCID: 0000-0002-8833-320X AD - Research Group EPINUT (Nutritional Epidemiology) Faculty of Medicine, Complutense University of Madrid, Madrid, Spain. FAU - Serrano, Maria Dolores Marrodan AU - Serrano MDM AUID- ORCID: 0000-0002-1697-1923 AD - Research Group EPINUT (Nutritional Epidemiology) Faculty of Medicine, Complutense University of Madrid, Madrid, Spain. AD - Department of Biodiversity, Ecology and Evolution, Faculty of Biology, Complutense University of Madrid, Madrid, Spain. LA - eng GR - Project PR41/17_21008/Fundacion Banco Santander/ PT - Evaluation Study PT - Journal Article PL - United States TA - Brain Behav JT - Brain and behavior JID - 101570837 SB - IM MH - Reproducibility of Results MH - *Feeding Behavior/physiology MH - *Surveys and Questionnaires/statistics & numerical data MH - *Pediatric Obesity/diagnosis/epidemiology/physiopathology/prevention & control MH - *Students/psychology/statistics & numerical data MH - Schools MH - Humans MH - Male MH - Female MH - Child MH - Adolescent MH - Translations MH - Spain/epidemiology MH - Nutritional Status/physiology MH - Body Mass Index MH - Prevalence MH - *Child Behavior/physiology MH - Linear Models MH - *Psychometrics/methods/statistics & numerical data PMC - PMC11839750 OTO - NOTNLM OT - appetite OT - eating behavior OT - pediatric obesity OT - satiety response COIS- The authors declare no conflicts of interest. EDAT- 2025/02/20 06:22 MHDA- 2025/02/20 06:23 PMCR- 2025/02/19 CRDT- 2025/02/20 01:03 PHST- 2025/01/24 00:00 [revised] PHST- 2024/04/06 00:00 [received] PHST- 2025/01/29 00:00 [accepted] PHST- 2025/02/20 06:23 [medline] PHST- 2025/02/20 06:22 [pubmed] PHST- 2025/02/20 01:03 [entrez] PHST- 2025/02/19 00:00 [pmc-release] AID - BRB370343 [pii] AID - 10.1002/brb3.70343 [doi] PST - ppublish SO - Brain Behav. 2025 Feb;15(2):e70343. doi: 10.1002/brb3.70343. PMID- 39972032 OWN - NLM STAT- MEDLINE DCOM- 20250219 LR - 20261014 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Feb 19 TI - Validation of SSDE calculation in a modern CT scanner and correlation with effective dose. PG - 6091 LID - 10.1038/s41598-025-90509-y [doi] LID - 6091 AB - This study aims to validate the Size Specific Dose Estimate (SSDE) provided by a modern Computed Tomography (CT) scanner and investigate its correlation with effective dose (E). SSDE is a size-specific dosimetric index addressing the limitations of the Computed Tomography Dose Index (CTDI(vol)). A set of 60 CT scans of anthropomorphic phantoms, including pediatric and obese models, were acquired and analyzed. SSDE values from the CT scanner were compared with those obtained through an independent Python-based calculation and Radimetrics, a dose monitor software. While the independent calculation and the one with Radimetrics were consistently in agreement, a systematic underestimation by the scanner up to 10% was seen, particularly in chest and abdominal exams. The underestimation, however, remained within the acceptable limits set by AAPM guidelines. Furthermore, a correlation between SSDE and effective dose was identified, suggesting SSDE's potential for more accurate, size-specific radiation dose and risk assessments. These findings highlight the importance of SSDE in enhancing patient-specific dose management, though further validation using patient data is needed to confirm its clinical applicability. CI - (c) 2025. The Author(s). FAU - Zancope, Nicola AU - Zancope N AD - Department of Physics and Astronomy "Galileo Galilei", University of Padova, Padua, Italy. FAU - De Monte, Francesca AU - De Monte F AD - Medical Physics Department, Veneto Institute of Oncology IOV - IRCCS, Via Gattamelata n. 64, Padua, 35128, Italy. francesca.demonte@iov.veneto.it. FAU - Simeone, Erica AU - Simeone E AD - Department of Physics and Astronomy "Galileo Galilei", University of Padova, Padua, Italy. FAU - Giannone, Angelo AU - Giannone A AD - Department of Physics and Astronomy "Galileo Galilei", University of Padova, Padua, Italy. FAU - Lombardi, Riccardo AU - Lombardi R AD - Department of Physics and Astronomy "Galileo Galilei", University of Padova, Padua, Italy. FAU - Mele, Alessandro AU - Mele A AD - Medical Physics Department, Veneto Institute of Oncology IOV - IRCCS, Via Gattamelata n. 64, Padua, 35128, Italy. FAU - Zorz, Alessandra AU - Zorz A AD - Medical Physics Department, Veneto Institute of Oncology IOV - IRCCS, Via Gattamelata n. 64, Padua, 35128, Italy. FAU - Di Paola, Alessandro AU - Di Paola A AD - Neuroradiology - Pediatric Radiology Unit, University-Hospital of Padua, Padua, Italy. FAU - Causin, Francesco AU - Causin F AD - Neuroradiology - Pediatric Radiology Unit, University-Hospital of Padua, Padua, Italy. FAU - Paiusco, Marta AU - Paiusco M AD - Medical Physics Department, Veneto Institute of Oncology IOV - IRCCS, Via Gattamelata n. 64, Padua, 35128, Italy. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250219 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Radiation Dosage MH - Phantoms, Imaging MH - *Tomography, X-Ray Computed/methods/instrumentation MH - *Tomography Scanners, X-Ray Computed MH - Radiometry/methods MH - Child PMC - PMC11840047 OTO - NOTNLM OT - CT OT - Effective dose OT - Radiation dose management OT - SSDE COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/02/20 00:21 MHDA- 2025/02/20 00:22 PMCR- 2025/02/19 CRDT- 2025/02/19 23:31 PHST- 2024/10/24 00:00 [received] PHST- 2025/02/13 00:00 [accepted] PHST- 2025/02/20 00:22 [medline] PHST- 2025/02/20 00:21 [pubmed] PHST- 2025/02/19 23:31 [entrez] PHST- 2025/02/19 00:00 [pmc-release] AID - 10.1038/s41598-025-90509-y [pii] AID - 90509 [pii] AID - 10.1038/s41598-025-90509-y [doi] PST - epublish SO - Sci Rep. 2025 Feb 19;15(1):6091. doi: 10.1038/s41598-025-90509-y. PMID- 39970479 OWN - NLM STAT- MEDLINE DCOM- 20250509 LR - 20260508 IS - 1365-2788 (Electronic) IS - 0964-2633 (Print) IS - 0964-2633 (Linking) VI - 69 IP - 5 DP - 2025 May TI - Anxiety, Depression and Stress in Parents and Siblings of People Who Have Prader-Willi Syndrome: Morbidity Prevalence and Mitigating Factors. PG - 417-427 LID - 10.1111/jir.13223 [doi] AB - BACKGROUND: Individuals with PWS need constant support and/or supervision, which creates a high caregiver burden on their parents and siblings. Previous research has identified adverse stress outcomes in relatively small and country-specific samples. This study's aims were to examine stress outcomes in a large multi-country sample of parents and siblings and to expand upon previous research by incorporating data on psychosocial factors that may mitigate stress outcomes. METHODS: The sample comprised 135 parents of a child with PWS, with additional data for 45 siblings as reported by parents. Participants were recruited from 31 countries, spanning Europe, North and South America, Africa, Asia and Australasia, who participated by completing an online questionnaire that included standardised psychometric measures of depression and anxiety (HADS), life stress (PSS), PTSD symptoms (CATS-C) and family cohesion (FACES II). Outcomes were compared to published population norms, and multiple regression was used to investigate the role of potential exacerbating and mitigating factors. RESULTS: Findings revealed high rates of mental pathologies in both parents and siblings. Parents' scores for depression and anxiety indicated high rates of caseness: 67.4% of parents exhibited 'abnormal' levels of anxiety, while 15.6% exhibited 'borderline abnormal' levels; 34.8% exhibited 'abnormal' levels of depression, with 22.2% exhibiting 'borderline abnormal' levels. Younger parents exhibited higher anxiety than older parents (p = 0.007); younger male parents reported higher depression than older male parents (p = 0.029). Parents whose child with PWS lived in the family home exhibited higher depression scores than parents whose child with PWS lived away from home (p = 0.035). Family cohesion was inversely associated with parental depression (p < 0.001) and parental anxiety (p = 0.012), even when statistically controlling for age of parent, age of child with PWS and parental education level. Scores for life stress were markedly higher than population norms, with 88.7% of parents exhibiting 'high' or 'moderate' life stress. Parental life stress was significantly correlated with temper outburst severity in their child with PWS (p < 0.001) and with food problem severity (p < 0.001). All siblings exhibited at least one symptom of PTSD, with 28.9% of siblings exhibiting 'clinically relevant' levels of PTSD symptoms. Sibling PTSD symptom levels were significantly associated with temper outburst severity in the child with PWS (p = 0.025) but not with ratings of food problem severity (p = 0.114). Family cohesion was inversely associated with PTSD symptoms in siblings (p = 0.022). CONCLUSIONS: PWS impacts families negatively, and relatives suffer as a result. The findings of this study confirm that parents and siblings of persons with PWS exhibit clinically notable levels of mental pathology. Strategies to enhance family cohesion should be employed to help diminish adverse outcomes among PWS families. CI - (c) 2025 The Author(s). Journal of Intellectual Disability Research published by MENCAP and John Wiley & Sons Ltd. FAU - Micallef Pule, Kristina AU - Micallef Pule K AD - School of Psychology, University of Galway, Galway, Ireland. FAU - Hughes, Brian M AU - Hughes BM AUID- ORCID: 0000-0002-6545-9248 AD - School of Psychology, University of Galway, Galway, Ireland. LA - eng GR - Government of Malta's Endeavour II Scholarships Scheme/ GR - ESF+ 2021-2027/ PT - Journal Article DEP - 20250219 PL - England TA - J Intellect Disabil Res JT - Journal of intellectual disability research : JIDR JID - 9206090 SB - IM MH - Humans MH - Male MH - Female MH - *Siblings/psychology MH - *Parents/psychology MH - Adult MH - *Anxiety/epidemiology MH - Child MH - *Depression/epidemiology MH - *Stress, Psychological/epidemiology MH - Middle Aged MH - *Prader-Willi Syndrome/epidemiology/nursing MH - Adolescent MH - Prevalence MH - Young Adult MH - Caregivers/psychology PMC - PMC11966354 OTO - NOTNLM OT - PTSD OT - PWS families OT - PWS parents OT - PWS siblings OT - Prader-Willi syndrome OT - anxiety OT - depression OT - family cohesion OT - social support OT - stress COIS- B.M.H. is a parent of an individual who has PWS. The authors declare no conflicts of interest. EDAT- 2025/02/19 18:21 MHDA- 2025/04/03 18:25 PMCR- 2025/04/03 CRDT- 2025/02/19 17:53 PHST- 2025/01/13 00:00 [received] PHST- 2025/02/04 00:00 [accepted] PHST- 2025/04/03 18:25 [medline] PHST- 2025/02/19 18:21 [pubmed] PHST- 2025/02/19 17:53 [entrez] PHST- 2025/04/03 00:00 [pmc-release] AID - JIR13223 [pii] AID - 10.1111/jir.13223 [doi] PST - ppublish SO - J Intellect Disabil Res. 2025 May;69(5):417-427. doi: 10.1111/jir.13223. Epub 2025 Feb 19. PMID- 39969796 OWN - NLM STAT- MEDLINE DCOM- 20250703 LR - 20261010 IS - 1720-8386 (Electronic) IS - 0391-4097 (Linking) VI - 48 IP - 6 DP - 2025 Jun TI - Extending curve matching with flexible hyperparameter selection to predict response to long-acting PEGylated growth hormone treatment in growth hormone deficiency children: method development and validation. PG - 1383-1392 LID - 10.1007/s40618-025-02546-z [doi] AB - PURPOSE: Curve matching can predict the height trajectories of children by analyzing longitudinal growth data. We extended the method to improve the prediction of response to long-acting growth hormone treatment in children with growth hormone deficiency (GHD). METHODS: We analyzed data from a previous real-world study with a 36-month treatment of PEGylated recombinant human growth hormone (PEG-rhGH). The matching database comprises height measures imputed using the broken stick method. For curve matching, we proposed a flexible hyperparameter selection approach to determining the number of similar patients. RESULTS: The matching database included 681 patients, with an average of 12.20 +/- 2.09 height measurements per patient. Our approach demonstrated significantly improved prediction accuracy compared with the previous approach using a fixed number of similar patients (mean squared errors of 0.0412 +/- 0.1156 vs. 0.564 +/- 0.1639, 0.851 +/- 0.2627, and 0.1077 +/- 0.2960 for 5, 10, and 15 similar patients, respectively, all P < 0.05). The optimal prediction scenario was having four height measurements within the first six months and predicting height trajectories from there on. CONCLUSION: By extending curve matching with flexible hyperparameter selection, we accurately predicted the response to long-acting PEG-rhGH in the GHD children included in this study. CI - (c) 2025. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE). FAU - Hou, Ling AU - Hou L AD - Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. FAU - Fu, Junfen AU - Fu J AD - Department of Endocrinology, National Clinical Research Center for Child Health, Children's Hospital of Zhejiang University School of Medicine, Zhejiang University School of Medicine, Hangzhou, 310052, China. FAU - Wei, Haiyan AU - Wei H AD - Department of Endocrinology and Metabolism, Henan Children's Hospital (Children's Hospital Affiliated to Zhengzhou University), Genetics, Zhengzhou, 450018, China. FAU - Liang, Liyang AU - Liang L AD - Department of Pediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China. FAU - Du, Hongwei AU - Du H AD - Department of Pediatrics, First Hospital of Jilin University, Changchun, 130021, China. FAU - Zhang, Jianping AU - Zhang J AD - Department of Pediatrics, Ningbo Women & Children's Hospital, Ningbo, 315012, China. FAU - Zhong, Yan AU - Zhong Y AD - Department of Child Health Care, Hunan Children's Hospital, Changsha, 410007, China. FAU - Chen, Ruimin AU - Chen R AD - Department of Endocrinology, Genetics and Metabolism, Fuzhou Children's Hospital of Fujian Medical University, Fuzhou, 350005, China. FAU - Cheng, Xinran AU - Cheng X AD - Department of Pediatric Endocrine Genetics and Metabolism, Chengdu Women's and Children's Center Hospital, Chengdu, 610074, China. FAU - Pan, Jiayan AU - Pan J AD - Department of Pediatrics, Wuhu First People's Hospital, Wuhu, 241000, China. FAU - Shan, Xiaoou AU - Shan X AD - Department of Genetics and Endocrinology, The Second Affiliated Hospital & Yuying, Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China. FAU - Zeng, Ting AU - Zeng T AD - Department of Child Health Care, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, 545001, China. FAU - Gong, Chunxiu AU - Gong C AD - Department of Endocrine and Genetics and Metabolism, Beijing Children's Hospital, Capital Medical University, National Centre for Children's Health, Beijing, 100045, China. FAU - Liao, Wei AU - Liao W AD - Department of Pediatrics, First Affiliated Hospital of Army Medical University (Third Military Medical University), Chongqing, 400038, China. FAU - Liu, Deyun AU - Liu D AD - Department of Pediatrics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China. FAU - Zhu, Shunye AU - Zhu S AD - Department of Pediatrics, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China. FAU - Lan, Dan AU - Lan D AD - Department of Pediatrics, the First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China. FAU - Dong, Zhiya AU - Dong Z AD - Department of Pediatrics, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China. FAU - Ma, Huamei AU - Ma H AD - Department of Pediatrics, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510062, China. FAU - Yang, Yu AU - Yang Y AD - Department of Endocrinology and Genetics, Jiangxi Provincial Children's Hospital, Affiliated Children's Hospital of Nanchang University, Nanchang, 330006, China. FAU - Zhu, Min AU - Zhu M AD - Department of Endocrinology, Children's Hospital of Chongqing Medical University, Chongqing, 400016, China. FAU - Sun, Wen AU - Sun W AD - Beijing Intelligent Decision Medical Technology Co. Ltd, Beijing, 100028, China. FAU - Luo, Xiaoping AU - Luo X AUID- ORCID: 0000-0002-3748-4817 AD - Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. xpluo@tjh.tjmu.edu.cn. LA - eng GR - 2023YFC2706300/Key Technologies Research and Development Program/ PT - Journal Article PT - Validation Study DEP - 20250219 PL - Italy TA - J Endocrinol Invest JT - Journal of endocrinological investigation JID - 7806594 RN - 12629-01-5 (Human Growth Hormone) RN - 3WJQ0SDW1A (Polyethylene Glycols) SB - IM MH - Humans MH - *Human Growth Hormone/deficiency/therapeutic use/administration & dosage MH - Child MH - Female MH - Male MH - *Body Height/drug effects MH - Child, Preschool MH - *Growth Disorders/drug therapy MH - *Polyethylene Glycols/therapeutic use MH - Prognosis MH - Adolescent MH - *Dwarfism, Pituitary/drug therapy MH - Follow-Up Studies MH - Treatment Outcome MH - Longitudinal Studies OTO - NOTNLM OT - Curve matching OT - Growth hormone deficiency OT - PEGylated recombinant human growth hormone OT - Pediatric growth trajectories OT - Predictive modeling OT - Treatment response COIS- Declarations. Declaration of competing interest: The authors report that there are no competing interests to declare. EDAT- 2025/02/19 12:25 MHDA- 2025/07/03 12:32 CRDT- 2025/02/19 11:23 PHST- 2024/11/14 00:00 [received] PHST- 2025/02/01 00:00 [accepted] PHST- 2025/07/03 12:32 [medline] PHST- 2025/02/19 12:25 [pubmed] PHST- 2025/02/19 11:23 [entrez] AID - 10.1007/s40618-025-02546-z [pii] AID - 10.1007/s40618-025-02546-z [doi] PST - ppublish SO - J Endocrinol Invest. 2025 Jun;48(6):1383-1392. doi: 10.1007/s40618-025-02546-z. Epub 2025 Feb 19. PMID- 39969082 OWN - NLM STAT- MEDLINE DCOM- 20260101 LR - 20260723 IS - 1552-6372 (Electronic) IS - 1524-8399 (Linking) VI - 27 IP - 1 DP - 2026 Jan TI - Comparison of Wear Compliance Across Three Accelerometer Protocols in Adolescents. PG - 56-64 LID - 10.1177/15248399251316517 [doi] AB - Introduction. While physical inactivity remains a pervasive public health problem, issues surrounding measuring physical activity plague researchers. Accelerometers are the gold-standard tool to assess physical activity and consumer-grade devices are increasingly used in research. However, accelerometer wear compliance varies by population and is influenced by factors, such as social acceptability, among others. Non-compliance threatens data validity and limits the usefulness regarding health promotion. Therefore, the purpose of this study is to compare the effects of three consumer-grade accelerometer protocols on wear compliance among adolescents. Methods. Study participants were provided a Garmin VivoFit4 accelerometer watch; participant wear compliance, steps, and physical activity were measured during the study period. Three methods of data collection were used to assess physical activity: (1) continuous wear, self-sync (n = 59); (2) continuous wear, researcher-sync (n = 160); and (3) intermittent wear, researcher-sync (n = 62). A one-way analysis of variance was conducted to assess between-group differences. Results. Mean valid days were significantly higher at baseline (F = 27.52, p < .001) and endpoint (F = 9.98, p < .001) for the intermittent wear, researcher-synced condition than for both the continuous wear conditions, and significantly higher at midpoint (F = 4.05, p < .05) for the continuous wear, research-synced condition. Conclusion. Study findings suggest that an intermittent wear, researcher-synced protocol significantly improves wear compliance and meets recommendations needed for reliable estimates of physical activity compared with continuous wear protocols as measured by mean valid days. Implementing protocols to increase wear compliance will improve data for interventional studies and health promotion capabilities of consumer-grade accelerometers. FAU - Grimes, Amanda AU - Grimes A AUID- ORCID: 0000-0002-0132-1696 AD - University of Missouri-Kansas City, Kansas City, MO, USA. FAU - Todd, Reagan AU - Todd R AD - University of Missouri-Kansas City, Kansas City, MO, USA. FAU - Sours, Olivia AU - Sours O AD - University of Missouri-Kansas City, Kansas City, MO, USA. FAU - Valleroy, Ella AU - Valleroy E AD - University of Missouri-Kansas City, Kansas City, MO, USA. FAU - Akagi-Bustin, Zakry AU - Akagi-Bustin Z AD - Kansas City Public Schools, Kansas City, MO, USA. FAU - Hillard, Natasha AU - Hillard N AD - University of Missouri-Kansas City, Kansas City, MO, USA. FAU - Lightner, Joseph S AU - Lightner JS AUID- ORCID: 0000-0002-8536-0085 AD - University of Missouri-Kansas City, Kansas City, MO, USA. LA - eng GR - 1 ASTWH190088-01-00/HH/HHS/United States PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. DEP - 20250219 PL - United States TA - Health Promot Pract JT - Health promotion practice JID - 100890609 SB - IM MH - Humans MH - Adolescent MH - *Accelerometry/instrumentation/methods MH - Female MH - Male MH - *Exercise MH - *Patient Compliance/statistics & numerical data OTO - NOTNLM OT - adherence OT - child/adolescent health OT - measurement OT - physical activity/exercise OT - program planning and evaluation OT - quantitative evaluation OT - youth EDAT- 2025/02/19 12:24 MHDA- 2026/01/01 07:37 CRDT- 2025/02/19 08:22 PHST- 2026/01/01 07:37 [medline] PHST- 2025/02/19 12:24 [pubmed] PHST- 2025/02/19 08:22 [entrez] AID - 10.1177/15248399251316517 [doi] PST - ppublish SO - Health Promot Pract. 2026 Jan;27(1):56-64. doi: 10.1177/15248399251316517. Epub 2025 Feb 19. PMID- 39967253 OWN - NLM STAT- MEDLINE DCOM- 20250219 LR - 20261018 IS - 2047-7163 (Electronic) IS - 0036-8504 (Print) IS - 0036-8504 (Linking) VI - 108 IP - 1 DP - 2025 Jan-Mar TI - Development and external validation of Global Leadership Initiative on Malnutrition-dictated nomograms predicting long-term mortality in hospitalized patients with cirrhosis. PG - 368504251320157 LID - 10.1177/00368504251320157 [doi] LID - 00368504251320157 AB - OBJECTIVES: Global Leadership Initiative on Malnutrition (GLIM) criteria have gradually accounted for the mainstay evaluating nutritional status. We sought to establish GLIM-dictated nomograms with other prognostic factors influencing long-term mortality and externally validate their predictive performance in decompensated cirrhosis. METHODS: The derivation cohort comprised 301 patients presenting with cirrhosis-associated acute insults, while the validation cohort encompassed 101 subjects from another tertiary hospital. Two nomograms were constructed to predict the 1-year all-cause mortality by integrating the GLIM criteria. The study population was stratified into low-, moderate- and high-risk mortality groups according to aforesaid proposed models. RESULTS: Adjusting Child-Turcotte-Pugh classification (Nomo#1) or Model for End-stage Liver Disease-Sodium score (Nomo#2) separately, the GLIM criteria were independently associated with 1-year mortality in the multivariate Cox regression analysis (Nomo#1 hazard ratio (HR) = 3.139, p < 0.001; Nomo#2 HR = 3.456, p < 0.001). The C-index and time AUC for Nomo#1 and Nomo#2 performed significantly better than those of the GLIM criteria or conventional scoring systems alone. The survival rate of the low-risk group was significantly higher than those of the moderate- or high-risk groups (Nomo#1: 95% vs 65.8% vs 33.3%, p < 0.001; Nomo#2: 94.3% vs 64.5% vs 25%, p < 0.001). Furthermore, our proposed models exhibited moderate prediction accuracy and may identify malnourished patients with poor survival conditions in the external validation cohort. CONCLUSION: GLIM criteria-defined malnutrition negatively impacted long-term mortality in the context of decompensated cirrhosis. Our established nomograms may predict survival status with sufficient discriminatory ability, alongside good consistency and clinical benefits, supporting their effectiveness in daily practice. FAU - Liu, Qing AU - Liu Q AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, China. FAU - He, Yumei AU - He Y AD - Department of Gastroenterology, The Third People's Hospital of Chengdu, Chengdu, China. FAU - Yang, Fang AU - Yang F AD - Department of Digestive System, Baodi Clinical College of Tianjin Medical University, Tianjin, China. FAU - Guo, Gaoyue AU - Guo G AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, China. FAU - Yang, Wanting AU - Yang W AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, China. FAU - Wu, Liping AU - Wu L AD - Department of Gastroenterology, The Third People's Hospital of Chengdu, Chengdu, China. FAU - Sun, Chao AU - Sun C AUID- ORCID: 0000-0002-0380-7999 AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, China. LA - eng PT - Journal Article PT - Validation Study PL - England TA - Sci Prog JT - Science progress JID - 0411361 SB - IM MH - Humans MH - *Liver Cirrhosis/mortality/complications MH - *Malnutrition/mortality/diagnosis MH - Male MH - Female MH - *Nomograms MH - Middle Aged MH - Aged MH - Hospitalization MH - Prognosis MH - Nutritional Status MH - Leadership MH - Proportional Hazards Models PMC - PMC11837080 OTO - NOTNLM OT - GLIM OT - liver cirrhosis OT - malnutrition OT - mortality OT - nomogram OT - prognosis COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/02/19 06:21 MHDA- 2025/02/19 06:22 PMCR- 2025/02/18 CRDT- 2025/02/19 01:22 PHST- 2025/02/19 06:22 [medline] PHST- 2025/02/19 06:21 [pubmed] PHST- 2025/02/19 01:22 [entrez] PHST- 2025/02/18 00:00 [pmc-release] AID - 10.1177_00368504251320157 [pii] AID - 10.1177/00368504251320157 [doi] PST - ppublish SO - Sci Prog. 2025 Jan-Mar;108(1):368504251320157. doi: 10.1177/00368504251320157. PMID- 39966666 OWN - NLM STAT- MEDLINE DCOM- 20260319 LR - 20260319 IS - 1476-5640 (Electronic) IS - 0954-3007 (Print) IS - 0954-3007 (Linking) VI - 79 IP - 12 DP - 2025 Dec TI - Validation of physical activity recall questionnaire and log using doubly-labelled water in Sri Lankan children. PG - 1211-1217 LID - 10.1038/s41430-025-01579-0 [doi] AB - BACKGROUND AND OBJECTIVE: Valid and cost-effective approaches are essential to assess physical activity and sedentary behaviours in individuals of all ages. This study aimed to validate a physical activity recall questionnaire (PAR-Q) and a physical activity log against the doubly labelled water (DLW) technique in 11-13-year-old Sri Lankan children. METHOD: Total energy expenditure (TEE) was determined using the criterion DLW technique (TEE(DLW)) and physical activity energy expenditure (PAEE(DLW)) was estimated. Subsequently, physical activity assessment methods were validated in a group of children (n = 79). PAR-Q was adapted from the adolescent physical activity questionnaire and the physical activity log from the Bouchard activity diary. The youth physical activity compendium was used to calculate PAEE from both PAR-Q (PAEE(PAR-Q)) and activity log (PAEE(PALog)). Statistical analysis included Pearson's correlation coefficient and Bland-Altman analyses. RESULTS: Mean age of the study sample was 12.0 +/- 0.8 years where the greater proportion were males (51.9%, n = 41). PAEE(PAR-Q) and PAEE(PALog) were significantly correlated with the PAEE(DLW) (r = 0.69 and r = 0.49, p < 0.05). PAR-Q underestimated PAEE by 230.1 +/- 1071.1 kJ/day. Physical activity log overestimated PAEE by 14.6 +/- 1283.2 kJ/day; for unit increase in the mean of the two measurements, the difference between the measurements increased by 0.48 (R(2) = 0.16, p < 0.001). CONCLUSION: PAR-Q is a valid tool for predicting PAEE in Sri Lankan children whereas the physical activity log was not. Researchers and practitioners can confidently use the PAR-Q to assess physical activity in this population, with potential applications in various research and intervention settings. CI - (c) 2025. The Author(s). FAU - Dabare, Prasangi AU - Dabare P AD - Department of Physiotherapy, Faculty of Allied Health Sciences, General Sir John Kotelawala Defense University, Colombo, Sri Lanka. FAU - Wickramasinghe, Pujitha AU - Wickramasinghe P AD - Department of Pediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. FAU - Waidyatilaka, Indu AU - Waidyatilaka I AD - Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. FAU - Devi, Sarita AU - Devi S AUID- ORCID: 0000-0002-8344-6897 AD - St. John's Research Institute, St. John's National Academy of Health Sciences, Bangalore, Karnataka, India. FAU - de Lanerolle Dias, Maduka AU - de Lanerolle Dias M AD - Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. FAU - Wickremasinghe, Rajitha AU - Wickremasinghe R AUID- ORCID: 0000-0002-6174-6784 AD - Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka. FAU - Samaranayake, Dulani AU - Samaranayake D AD - Department of Community Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. FAU - Jayawardena, Ranil AU - Jayawardena R AUID- ORCID: 0000-0002-7352-9365 AD - Department of Physiology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. FAU - Hills, Andrew P AU - Hills AP AUID- ORCID: 0000-0002-7787-7201 AD - School of Health Sciences, College of Health and Medicine, University of Tasmania, Hobart, Australia. andrew.hills@utas.edu.au. FAU - Lanerolle, Pulani AU - Lanerolle P AD - Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. LA - eng GR - SRL/06/035/International Atomic Energy Agency (IAEA)/ PT - Journal Article PT - Validation Study DEP - 20250218 PL - England TA - Eur J Clin Nutr JT - European journal of clinical nutrition JID - 8804070 RN - 0 (Oxygen Isotopes) SB - IM MH - *Surveys and Questionnaires MH - *Exercise MH - Mental Recall MH - Sri Lanka MH - Humans MH - Child MH - Adolescent MH - Energy Metabolism MH - Male MH - Female MH - Sedentary Behavior MH - Reproducibility of Results MH - Oxygen Isotopes/urine PMC - PMC12678185 COIS- Competing interests: The authors declare no competing interests. Ethical approval: The study was approved by the Ethics Review Committee of the Faculty of Medicine, University of Colombo, Sri Lanka (EC/16/192). EDAT- 2025/02/19 00:15 MHDA- 2025/12/05 01:02 PMCR- 2025/02/18 CRDT- 2025/02/18 23:49 PHST- 2024/03/01 00:00 [received] PHST- 2025/02/06 00:00 [accepted] PHST- 2025/01/11 00:00 [revised] PHST- 2025/12/05 01:02 [medline] PHST- 2025/02/19 00:15 [pubmed] PHST- 2025/02/18 23:49 [entrez] PHST- 2025/02/18 00:00 [pmc-release] AID - 10.1038/s41430-025-01579-0 [pii] AID - 1579 [pii] AID - 10.1038/s41430-025-01579-0 [doi] PST - ppublish SO - Eur J Clin Nutr. 2025 Dec;79(12):1211-1217. doi: 10.1038/s41430-025-01579-0. Epub 2025 Feb 18. PMID- 39965021 OWN - NLM STAT- MEDLINE DCOM- 20250305 LR - 20261001 IS - 1935-2735 (Electronic) IS - 1935-2727 (Print) IS - 1935-2727 (Linking) VI - 19 IP - 2 DP - 2025 Feb TI - Treatment heterogeneity of water, sanitation, hygiene, and nutrition interventions on child growth by environmental enteric dysfunction and pathogen status for young children in Bangladesh. PG - e0012881 LID - 10.1371/journal.pntd.0012881 [doi] LID - e0012881 AB - BACKGROUND: Water, sanitation, hygiene (WSH), nutrition (N), and combined (N+WSH) interventions are often implemented by global health organizations, but WSH interventions may insufficiently reduce pathogen exposure, and nutrition interventions may be modified by environmental enteric dysfunction (EED), a condition of increased intestinal permeability and inflammation. This study investigated the heterogeneity of these treatments' effects based on individual pathogen and EED biomarker status with respect to child linear growth. METHODS: We applied cross-validated targeted maximum likelihood estimation and super learner ensemble machine learning to assess the conditional treatment effects in subgroups defined by biomarker and pathogen status. We analyzed treatment (N+WSH, WSH, N, or control) randomly assigned in-utero, child pathogen and EED data at 14 months of age, and child HAZ at 28 months of age. We estimated the difference in mean child height for age Z-score (HAZ) under the treatment rule and the difference in stratified treatment effect (treatment effect difference) comparing children with high versus low pathogen/biomarker status while controlling for baseline covariates. RESULTS: We analyzed data from 1,522 children who had a median HAZ of -1.56. We found that fecal myeloperoxidase (N+WSH treatment effect difference 0.0007 HAZ, WSH treatment effect difference 0.1032 HAZ, N treatment effect difference 0.0037 HAZ) and Campylobacter infection (N+WSH treatment effect difference 0.0011 HAZ, WSH difference 0.0119 HAZ, N difference 0.0255 HAZ) were associated with greater effect of all interventions on anthropometry. In other words, children with high myeloperoxidase or Campylobacter infection experienced a greater impact of the interventions on anthropometry. We found that a treatment rule that assigned the N+WSH (HAZ difference 0.23, 95% CI (0.05, 0.41)) and WSH (HAZ difference 0.17, 95% CI (0.04, 0.30)) interventions based on EED biomarkers and pathogens increased predicted child growth compared to the randomly allocated intervention. CONCLUSIONS: These findings indicate that EED biomarkers and pathogen status, particularly Campylobacter and myeloperoxidase (a measure of gut inflammation), may be related to the impact of N+WSH, WSH, and N interventions on child linear growth. CI - Copyright: (c) 2025 Butzin-Dozier et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Butzin-Dozier, Zachary AU - Butzin-Dozier Z AUID- ORCID: 0000-0001-6419-0008 AD - School of Public Health, University of California, Berkeley, California, United States of America. FAU - Ji, Yunwen AU - Ji Y AD - School of Public Health, University of California, Berkeley, California, United States of America. FAU - Coyle, Jeremy AU - Coyle J AD - School of Public Health, University of California, Berkeley, California, United States of America. FAU - Malenica, Ivana AU - Malenica I AD - School of Public Health, University of California, Berkeley, California, United States of America. FAU - Rogawski McQuade, Elizabeth T AU - Rogawski McQuade ET AUID- ORCID: 0000-0002-4942-3747 AD - Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America. FAU - Grembi, Jessica Anne AU - Grembi JA AD - Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States of America. FAU - Platts-Mills, James A AU - Platts-Mills JA AD - School of Medicine, University of Virginia, Charlottesville, Virginia, United States of America. FAU - Houpt, Eric R AU - Houpt ER AD - School of Medicine, University of Virginia, Charlottesville, Virginia, United States of America. FAU - Graham, Jay P AU - Graham JP AD - School of Public Health, University of California, Berkeley, California, United States of America. FAU - Ali, Shahjahan AU - Ali S AD - International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. FAU - Rahman, Md Ziaur AU - Rahman MZ AD - Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, California, United States of America. FAU - Alauddin, Mohammad AU - Alauddin M AD - Wagner College, Staten Island, New York, New York, United States of America. FAU - Famida, Syeda L AU - Famida SL AD - International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. FAU - Akther, Salma AU - Akther S AD - International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. FAU - Hossen, Md Saheen AU - Hossen MS AD - International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. FAU - Mutsuddi, Palash AU - Mutsuddi P AD - International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. FAU - Shoab, Abul K AU - Shoab AK AD - International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. FAU - Rahman, Mahbubur AU - Rahman M AUID- ORCID: 0000-0003-0520-2683 AD - International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. FAU - Islam, Md Ohedul AU - Islam MO AD - International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. FAU - Miah, Rana AU - Miah R AD - International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. FAU - Taniuchi, Mami AU - Taniuchi M AD - School of Medicine, University of Virginia, Charlottesville, Virginia, United States of America. FAU - Liu, Jie AU - Liu J AD - School of Public Health, Qingdao University, Qingdao, China. FAU - Alauddin, Sarah T AU - Alauddin ST AD - Wagner College, Staten Island, New York, New York, United States of America. FAU - Stewart, Christine P AU - Stewart CP AUID- ORCID: 0000-0003-4575-8571 AD - Institute for Global Nutrition, University of California, Davis, California, United States of America. FAU - Luby, Stephen P AU - Luby SP AUID- ORCID: 0000-0001-5385-899X AD - Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, California, United States of America. FAU - Colford, John M Jr AU - Colford JM Jr AD - School of Public Health, University of California, Berkeley, California, United States of America. FAU - Hubbard, Alan E AU - Hubbard AE AUID- ORCID: 0000-0002-3769-0127 AD - School of Public Health, University of California, Berkeley, California, United States of America. FAU - Mertens, Andrew N AU - Mertens AN AUID- ORCID: 0000-0002-1050-6721 AD - School of Public Health, University of California, Berkeley, California, United States of America. FAU - Lin, Audrie AU - Lin A AUID- ORCID: 0000-0002-3877-3469 AD - Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, California, United States of America. LA - eng GR - K01 AI136885/AI/NIAID NIH HHS/United States GR - K01 AI182501/AI/NIAID NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20250218 PL - United States TA - PLoS Negl Trop Dis JT - PLoS neglected tropical diseases JID - 101291488 RN - 0 (Biomarkers) SB - IM UOF - medRxiv. 2024 Mar 26:2024.03.21.24304684. doi: 10.1101/2024.03.21.24304684. PMID: 38585931 MH - Humans MH - Bangladesh/epidemiology MH - *Sanitation MH - Infant MH - Female MH - Male MH - *Hygiene MH - Child, Preschool MH - *Child Development MH - Biomarkers MH - Nutritional Status PMC - PMC11882089 COIS- The authors have declared that no competing interests exist. EDAT- 2025/02/18 18:20 MHDA- 2025/03/05 18:20 PMCR- 2025/02/18 CRDT- 2025/02/18 13:53 PHST- 2024/06/12 00:00 [received] PHST- 2025/01/30 00:00 [accepted] PHST- 2025/03/05 00:00 [revised] PHST- 2025/03/05 18:20 [medline] PHST- 2025/02/18 18:20 [pubmed] PHST- 2025/02/18 13:53 [entrez] PHST- 2025/02/18 00:00 [pmc-release] AID - PNTD-D-24-00822 [pii] AID - 10.1371/journal.pntd.0012881 [doi] PST - epublish SO - PLoS Negl Trop Dis. 2025 Feb 18;19(2):e0012881. doi: 10.1371/journal.pntd.0012881. eCollection 2025 Feb. PMID- 39964683 OWN - NLM STAT- MEDLINE DCOM- 20250508 LR - 20250730 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 8 IP - 2 DP - 2025 Feb 3 TI - Neural Response to Food Cues in Avoidant/Restrictive Food Intake Disorder. PG - e2460101 LID - 10.1001/jamanetworkopen.2024.60101 [doi] LID - e2460101 AB - IMPORTANCE: The neurobiology of avoidant/restrictive food intake disorder (ARFID) is poorly understood. OBJECTIVE: To evaluate whether individuals with ARFID exhibit disruptions in fear, appetite, and disgust brain regions compared with healthy control (HC) participants when shown images of food and objects. DESIGN, SETTING, AND PARTICIPANTS: In this case-control study conducted from July 2016 to January 2021, children, adolescents, and young adults completed structured interviews and a validated functional magnetic resonance imaging (fMRI) food cue paradigm. The study was conducted at a single academic medical center. Data analysis was conducted from April 2023 to August 2024. EXPOSURES: Presence vs absence of ARFID and its phenotypes (ARFID-fear, ARFID-lack of interest in eating, ARFID-sensory sensitivity); pictures of food vs objects during fMRI food cue paradigm. MAIN OUTCOMES AND MEASURES: Blood oxygenation level-dependent activation in regions of interest (ROIs; amygdala, hypothalamus, insula, anterior cingulate cortex [ACC]) and the whole brain. RESULTS: Participants were 110 children, adolescents, and young adults with full or subthreshold ARFID (75 participants; mean [SD] age, 16.2 [3.8] years; 41 [55%] female) and age-matched HC participants (35 participants; mean [SD] age, 17.3 [4.0] years; 27 [69%] female) recruited for studies of the neurobiology of ARFID and restrictive eating disorders. Participants with ARFID demonstrated greater activation than HC participants of the ACC (mean difference, 0.48 [95% CI, 0.19 to 0.77]; P = .009), sensory association cortex (mean difference on left side, 0.54 [95% CI, 0.29 to 0.79]; P = .005; right side, 0.52 [95% CI, 0.28 to 0.76]; P = .02), and supplementary motor cortex (mean difference, 0.81 [95% CI, 0.47 to 1.15]; P = .04). The ARFID-fear group showed greater amygdala activation vs HC (mean difference, 0.49 [95% CI, 0.16 to 0.82]; P = .04), and greater lack of interest was associated with lower hypothalamus activation in the ARFID-lack of interest group (r = -0.38 [95% CI, -0.69 to -0.11]; P = .03). The ARFID-sensory sensitivity group did not show greater insula activation vs HC but showed greater activation of the ACC (mean difference, 0.48 [95% CI, 0.22 to 0.74]; P = .005) and somatosensory cortex (mean difference on left side, 0.60 [95% CI, 0.33-0.87]; P = .001; right side, 0.54 [95% CI, 0.29 to 0.80]; P = .03). CONCLUSIONS AND RELEVANCE: Results indicate generalized hyperactivation of ACC, sensory association cortex, and supplementary motor cortex in response to visual food stimuli in children, adolescents, and young adults with ARFID, suggesting a novel neurobiological circuit associated with this disorder. Activation appears consistent with ARFID phenotypic rationales for food avoidance, with hyperactivation of fear regions in ARFID-fear and hypoactivation of appetite regions with increasing ARFID-lack of interest severity. FAU - Thomas, Jennifer J AU - Thomas JJ AD - Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston. AD - Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts. FAU - Holsen, Laura AU - Holsen L AD - Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts. AD - Division of Women's Health, Department of Medicine, and Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts. FAU - Van De Water, Avery L AU - Van De Water AL AD - Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts. AD - Division of Women's Health, Department of Medicine, and Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts. AD - Neuroendocrine Unit, Massachusetts General Hospital, Boston. FAU - Becker, Kendra R AU - Becker KR AD - Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston. AD - Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts. FAU - Breithaupt, Lauren AU - Breithaupt L AD - Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston. AD - Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts. FAU - Burton-Murray, Helen AU - Burton-Murray H AD - Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts. AD - Center for Neurointestinal Health, Division of Gastroenterology, Massachusetts General Hospital, Boston. FAU - Asanza, Elisa AU - Asanza E AD - Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts. AD - Neuroendocrine Unit, Massachusetts General Hospital, Boston. FAU - Gydus, Julia AU - Gydus J AD - Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston. AD - Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts. AD - Neuroendocrine Unit, Massachusetts General Hospital, Boston. FAU - Palmer, Lilian P AU - Palmer LP AD - Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston. AD - Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts. FAU - Stern, Casey M AU - Stern CM AD - Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston. AD - Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts. FAU - Freizinger, Melissa AU - Freizinger M AD - Harvard Medical School, Boston, Massachusetts. AD - Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, Massachusetts. FAU - Shrier, Lydia A AU - Shrier LA AD - Harvard Medical School, Boston, Massachusetts. AD - Division of Adolescent/Young Adult Medicine, Boston Children's Hospital, Boston, Massachusetts. FAU - Bern, Elana M AU - Bern EM AD - Harvard Medical School, Boston, Massachusetts. AD - Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts. FAU - Deckersbach, Thilo AU - Deckersbach T AD - Harvard Medical School, Boston, Massachusetts. AD - Division of Neurotherapeutics, Massachusetts General Hospital, Charlestown. AD - University of Applied Sciences, DIPLOMA Hochschule, Bad Sooden-Allendorf, Germany. FAU - Misra, Madhusmita AU - Misra M AD - Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts. AD - Department of Pediatrics, University of Virginia, Charlottesville. FAU - Eddy, Kamryn T AU - Eddy KT AD - Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston. AD - Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts. FAU - Micali, Nadia AU - Micali N AD - Eating Disorders Research Unit, Mental Health Center Ballerup, Mental Health Services of the Capital Region of Denmark, Ballerup, Denmark. AD - Great Ormond Street Institute of Child Health, University College London, London, United Kingdom. FAU - Lawson, Elizabeth AU - Lawson E AD - Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts. AD - Neuroendocrine Unit, Massachusetts General Hospital, Boston. LA - eng GR - K24 MH135189/MH/NIMH NIH HHS/United States GR - P30 DK040561/DK/NIDDK NIH HHS/United States GR - R01 MH128246/MH/NIMH NIH HHS/United States GR - R01 MH108595/MH/NIMH NIH HHS/United States GR - R01 MH103402/MH/NIMH NIH HHS/United States GR - K24 MH120568/MH/NIMH NIH HHS/United States GR - K23 MH125143/MH/NIMH NIH HHS/United States GR - K23 MH127465/MH/NIMH NIH HHS/United States GR - K23 DK131334/DK/NIDDK NIH HHS/United States GR - UL1 TR002541/TR/NCATS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20250203 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Humans MH - Female MH - Adolescent MH - Male MH - Magnetic Resonance Imaging MH - *Cues MH - Child MH - Case-Control Studies MH - Young Adult MH - *Avoidant Restrictive Food Intake Disorder/physiopathology/psychology/diagnostic imaging MH - *Brain/physiopathology/diagnostic imaging MH - Fear/physiology MH - Amygdala/physiopathology/diagnostic imaging MH - Food MH - Adult PMC - PMC11836757 COIS- Conflict of Interest Disclosures: Dr Thomas reported receiving grants from the National Institutes of Health (NIH) during the conduct of the study as well as receiving royalties from Cambridge University Press and receiving consulting fees from Equip Health outside the submitted work. Dr Holsen reported receiving grants from NIH during the conduct of the study. Dr Becker reported receiving grants from the National Institute of Mental Health during the conduct of the study as well as receiving royalties from Cambridge University Press outside the submitted work. Dr Breithaupt reporting serving as a consultant for Otsuka Pharmaceuticals and HealthiVibe. Dr Burton-Murray reported receiving grants from the National Institute of Diabetes and Digestive and Kidney Diseases during the conduct of the study. Dr Bern reported spousal employment by and stock ownership in Novartis and receiving travel and honoraria from Abbott Nutrition International. Dr Misra reported receiving consulting fees from Regeneron, Sanofi, and AbbVie; receiving royalties UpToDate; serving on an expert panel for Lumos Pharmaceuticals; serving on the scientific advisory board for AbbVie and Ipsen; and receiving a study drug donation from Tonix Pharmaceuticals outside the submitted work. Dr Eddy reported grants from National Institute of Mental Health during the conduct of the study as well as receiving royalties from Cambridge University Press Book and consulting fees from Equip Health outside the submitted work. Prof Micali reported receiving grants from University of Geneva during the conduct of the study. Dr Lawson reported receiving grants from the NIH during the conduct of the study; receiving grants from Tonix Pharmaceuticals outside the submitted work; having patents for 63/413,657 and 63/467,980 pending; receiving royalties from UpToDate; and holding and/or having immediate family with stock in Thermo Fisher Scientific, Zoetis, Danaher Corporation, Intuitive Surgical, and Merck and West Pharmaceutical Services. No other disclosures were reported. EDAT- 2025/02/18 12:25 MHDA- 2025/02/18 12:26 PMCR- 2025/02/18 CRDT- 2025/02/18 11:33 PHST- 2025/02/18 12:26 [medline] PHST- 2025/02/18 12:25 [pubmed] PHST- 2025/02/18 11:33 [entrez] PHST- 2025/02/18 00:00 [pmc-release] AID - 2830346 [pii] AID - zoi241679 [pii] AID - 10.1001/jamanetworkopen.2024.60101 [doi] PST - epublish SO - JAMA Netw Open. 2025 Feb 3;8(2):e2460101. doi: 10.1001/jamanetworkopen.2024.60101. PMID- 39962476 OWN - NLM STAT- MEDLINE DCOM- 20250508 LR - 20250508 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Feb 17 TI - Minimum diet diversity-women score and predictors of school adolescent girl stunting and thinness in Northwest Ethiopia. PG - 637 LID - 10.1186/s12889-025-21913-2 [doi] LID - 637 AB - BACKGROUND: Limited data exist on adolescent nutrition. This school-based cross-sectional study aimed to assess dietary practices, nutritional status, and associated factors among adolescent girls. METHODS: Two hundred seventy-nine primary and secondary school girls were selected via multistage sampling. A pretested questionnaire and 24-h recall method were employed to gather data on background characteristics and dietary practices. The questionnaire was pretested with 20 adolescents from nonparticipating schools to assess clarity and reliability. Feedback from the pretest was used to refine the questionnaire. The minimum dietary diversity for women (MDD-W) was used as an indicator of diet quality, where women were considered to have adequate dietary diversity if they consumed at least five of ten food groups in the past 24 h. Key informant interviews were used to explore nutritional problems, while anthropometric measurements were taken to assess nutritional status. Height and weight, combined with age, were used to calculate height-for-age and BMI-for-age z scores via WHO AnthroPlus software. Nutritional status was categorized as stunted (< -2SD), thin (< -2SD), normal (-2SD to + 2SD), or overweight (> + 2SD). A multivariate binary logistic regression model identified predictors of nutritional status. The quantitative data were analyzed via SPSS, and the qualitative data were analyzed via ATLAS.ti. RESULTS: Only 24% of the students met the MDD-W. Predominant consumption of plant-source foods (100%) and low animal-source food intake (< 20%) were observed. Environmental, social, and cultural factors are barriers to nutrition, whereas cultural food preferences act as reinforcing factors. The prevalence rates of thinness, stunting, and overweight were 7.2%, 6.4%, and 5.7%, respectively, with undernutrition being more prevalent in younger adolescents (10-14 years). Adolescents with low fast food consumption and those in late adolescence were less likely to be stunted or thin. CONCLUSION: Poor dietary practices and undernutrition, particularly among younger adolescents, were observed. Comprehensive programs addressing environmental, social, and cultural barriers are needed to improve adolescent nutrition. CI - (c) 2025. The Author(s). FAU - Melesse, Yajeb AU - Melesse Y AD - Center for Food Science and Nutrition, Addis Ababa University, Addis Ababa, Ethiopia. FAU - Abebe, Zeweter AU - Abebe Z AD - Center for Food Science and Nutrition, Addis Ababa University, Addis Ababa, Ethiopia. zeweterab@gmail.com. LA - eng PT - Journal Article DEP - 20250217 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - Adolescent MH - Ethiopia/epidemiology MH - Cross-Sectional Studies MH - *Thinness/epidemiology MH - *Diet/statistics & numerical data/standards MH - *Growth Disorders/epidemiology MH - Surveys and Questionnaires MH - Nutritional Status MH - Child PMC - PMC11831835 OTO - NOTNLM OT - Adolescents OT - Dietary practices OT - Girls OT - MDD-W OT - Nutritional status COIS- Declarations. Ethics approval and consent to participate: Before the data collection, an ethical approval letter was obtained from the College of Natural and Computational Sciences institutional review board of Addis Ababa University (Ref no: CNCSDO/616/13/2021). The participants acted anonymously and voluntarily, without payment, and could leave the form incomplete if pertinent. Informed consent was obtained from all the subjects and/or their legal guardian(s). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/02/18 06:22 MHDA- 2025/02/18 06:23 PMCR- 2025/02/17 CRDT- 2025/02/18 00:07 PHST- 2024/09/30 00:00 [received] PHST- 2025/02/12 00:00 [accepted] PHST- 2025/02/18 06:23 [medline] PHST- 2025/02/18 06:22 [pubmed] PHST- 2025/02/18 00:07 [entrez] PHST- 2025/02/17 00:00 [pmc-release] AID - 10.1186/s12889-025-21913-2 [pii] AID - 21913 [pii] AID - 10.1186/s12889-025-21913-2 [doi] PST - epublish SO - BMC Public Health. 2025 Feb 17;25(1):637. doi: 10.1186/s12889-025-21913-2. PMID- 39953458 OWN - NLM STAT- MEDLINE DCOM- 20250215 LR - 20260610 IS - 1471-244X (Electronic) IS - 1471-244X (Linking) VI - 25 IP - 1 DP - 2025 Feb 14 TI - Relationship between parental perfectionism and child's disordered eating: mediating role of parental distress and validation of the arabic version of the eating disorders examination questionnaire-short-parent version (EDE-QS-P). PG - 127 LID - 10.1186/s12888-025-06589-7 [doi] LID - 127 AB - BACKGROUND: Eating disorders are an emerging global health crisis, with significant implications for both physical and psychological well-being. Disordered eating behaviors in childhood can serve as precursors to more severe eating disorders if left untreated. Previous literature evidences a strong association between perfectionism, as well as parental control and eating disorders, highlighting perfectionism as a significant factor in the development and maintenance of ED symptoms. Early intervention during this critical developmental period is essential to address these risks, prevent the progression to clinical eating disorders, and support healthier long-term outcomes for children. This study aimed to assess the mediating role of parental psychological distress in the association between perfectionism in parents and disordered eating in children. As a secondary objective, the study intended to validate the Arabic version of the Eating Disorders Examination Questionnaire-Short Parent Version (EDE-QS-P). METHODS: A diverse sample of Lebanese parents of children aged 6-11 years (N = 502; mean age of 36.24 +/- 8.29 years, 74.5% of mothers) were recruited from schools, community centers, and healthcare facilities into this cross-sectional study. One parent per child completed all the questionnaires, which assessed disordered eating in children, parental perfectionism, and psychological distress. The instruments used included the Eating Disorder Examination Questionnaire-Short Parent Version (EDE-QS-P) for disordered eating, the Big Three Perfectionism Scale - Short Form (BTPS-SF) for parental perfectionism, and the Depression, Anxiety, and Stress Scale-8 Items (DASS-8) for parental psychological distress. The SPSS software v.25 was used for statistical analysis. To examine the factor structure of the EDE-QS-P, we conducted a Confirmatory Factor Analysis (CFA) using SPSS AMOS v.28 software. The mediation analysis was conducted using PROCESS MACRO v.3.4 model 4. RESULTS: The Arabic EDE-QS-P showed a unidimensional factor structure, strong internal consistency reliability and high convergent validity. Higher child's disordered eating scores were reported by fathers compared to mothers (8.32 +/- 9.12 vs. 5.62 +/- 7.69, t (500) = 3.01, p = 0.003). Parental distress mediated the association between parental perfectionism and child's disordered eating (indirect effect: Beta = 0.14; Boot SE = 0.02; Boot CI 0.11; 0.18). More parental perfectionism was significantly associated with more parental distress, and higher parental distress was significantly associated with more child's disordered eating. Higher parental perfectionism was significantly and directly associated with more child's disordered eating. CONCLUSION: This study successfully validated the Arabic version of the EDE-QS-P in Lebanon, confirming its validity and reliability for assessing parental-reported disordered eating in children in Arab contexts. Elevated parental perfectionism correlates with increased child disordered eating, mediated by parental distress. This suggests that healthcare providers should be alert to signs of perfectionism and psychological distress in parents and provide appropriate interventions, such as cognitive-behavioral therapy or stress management techniques, to alleviate these issues and lower the risk of eating disorders in children. CI - (c) 2025. The Author(s). FAU - Kfoury, Maya AU - Kfoury M AD - School of Arts and Science, Holy Spirit University of Kaslik, P.O. Box 446, Jounieh, Lebanon. AD - Department of Psychology, Clinical Child and Adolescent Psychology and Psychotherapy, Saarland University, Saarbrucken, Germany. FAU - Noureddine, Amir AU - Noureddine A AD - School of Medicine and Medical Sciences, Holy Spirit University of Kaslik, P.O. Box 446, Jounieh, Lebanon. FAU - Malaeb, Diana AU - Malaeb D AD - College of Pharmacy, Gulf Medical University, Ajman, United Arab Emirates. FAU - Schuch, Felipe Barreto AU - Schuch FB AD - Department of Sports Methods and Techniques, Federal University of Santa Maria, Santa Maria, Brazil. AD - Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. AD - Faculty of Health Sciences, Universidad Autonoma de Chile, Providencia, Chile. FAU - El Khatib, Sami AU - El Khatib S AD - Department of Food Sciences and Technology, Faculty of Arts and Sciences, Lebanese International University, Bekaa Campus, Khiyara, Bekaa, 1108, Lebanon. AD - Center for Applied Mathematics and Bioinformatics, Gulf University for Science and Technology, Hawally, Kuwait. FAU - Dabbous, Mariam AU - Dabbous M AD - School of Pharmacy, Lebanese International University, Beirut, Lebanon. FAU - Sakr, Fouad AU - Sakr F AD - School of Pharmacy, Lebanese International University, Beirut, Lebanon. FAU - Fekih-Romdhane, Feten AU - Fekih-Romdhane F AD - The Tunisian Center of Early Intervention in Psychosis, Department of psychiatry "Ibn Omrane", Razi Hospital, Manouba, 2010, Tunisia. AD - Faculty of Medicine of Tunis, Tunis El Manar University, Tunis, Tunisia. FAU - Hallit, Souheil AU - Hallit S AD - School of Medicine and Medical Sciences, Holy Spirit University of Kaslik, P.O. Box 446, Jounieh, Lebanon. souheilhallit@usek.edu.lb. AD - Psychology Department, College of Humanities, Effat University, Jeddah, 21478, Saudi Arabia. souheilhallit@usek.edu.lb. AD - Applied Science Research Center, Applied Science Private University, Amman, Jordan. souheilhallit@usek.edu.lb. FAU - Obeid, Sahar AU - Obeid S AD - Social and Education Sciences Department, School of Arts and Sciences, Lebanese American University, Jbeil, Lebanon. LA - eng PT - Journal Article PT - Validation Study DEP - 20250214 PL - England TA - BMC Psychiatry JT - BMC psychiatry JID - 100968559 SB - IM MH - Humans MH - *Perfectionism MH - Female MH - Child MH - Male MH - *Parents/psychology MH - Adult MH - Surveys and Questionnaires MH - *Feeding and Eating Disorders/psychology/diagnosis MH - Cross-Sectional Studies MH - Lebanon MH - *Psychological Distress MH - Reproducibility of Results MH - *Stress, Psychological/psychology MH - Psychometrics MH - Parent-Child Relations PMC - PMC11829399 OTO - NOTNLM OT - Arabic OT - Disordered eating OT - Eating disorder examination OT - Eating disorders OT - Perfectionism OT - Psychological distress OT - Psychometric properties COIS- Declarations. Ethics approval and consent to participate: The study protocol was approved by the ethics committee of the School of Pharmacy at the Lebanese International University. Participants were asked to get their parents' approval before filling the survey; an electronic informed consent was considered obtained from each participant when submitting the online form. All methods were carried out in accordance with relevant guidelines and regulations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/02/15 15:12 MHDA- 2025/02/15 15:13 PMCR- 2025/02/14 CRDT- 2025/02/14 23:36 PHST- 2024/02/22 00:00 [received] PHST- 2025/02/06 00:00 [accepted] PHST- 2025/02/15 15:13 [medline] PHST- 2025/02/15 15:12 [pubmed] PHST- 2025/02/14 23:36 [entrez] PHST- 2025/02/14 00:00 [pmc-release] AID - 10.1186/s12888-025-06589-7 [pii] AID - 6589 [pii] AID - 10.1186/s12888-025-06589-7 [doi] PST - epublish SO - BMC Psychiatry. 2025 Feb 14;25(1):127. doi: 10.1186/s12888-025-06589-7. PMID- 39950025 OWN - NLM STAT- MEDLINE DCOM- 20250507 LR - 20250507 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 16 DP - 2025 TI - Higher Life's Crucial 9 protects against infertility among U.S. women aged 18-45 years. PG - 1465022 LID - 10.3389/fendo.2025.1465022 [doi] LID - 1465022 AB - OBJECTIVE: Infertility is not only a reproductive issue but is also closely linked to cardiovascular health and other factors. Life's Crucial 9 (LC9) is a set of lifestyle guidelines aimed at improving cardiovascular health, yet its potential association with infertility remains underexplored. This study aims to investigate the relationship between LC9 and infertility, providing new insights and strategies for the prevention and management of infertility. METHODS: This study utilized data from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2018. Multivariate logistic regression and weighted quantile sum (WQS) regressions were employed to investigate the association between LC9 and infertility. Restricted cubic spline (RCS) analysis explored the linear or non-linear relationship between LC9 and infertility. Interaction analyses were conducted on subgroups to validate the findings. RESULTS: There was a significant negative association between LC9 and infertility. After adjusting for covariates, for every 10-point increase in LC9, there was a 35% decrease in the prevalence of infertility (P < 0.001). This negative correlation persisted when LC9 was divided into quartiles. Moreover, as LC9 increased, there was a trend towards lower infertility prevalence (P for trend < 0.001). WQS analyses showed consistent associations (OR=0.27, 95%CI: 0.14, 0.53), with sleep health score, psychological health score, and Body mass index score as significant factors. The dose-response curve indicated a linear association between LC9 and infertility, with higher LC9 associated with lower infertility risk. CONCLUSION: The results of this study show a strong negative correlation between LC9 and the prevalence of infertility. Clinically, these findings offer hope for infertility patients, suggesting that adherence to a higher LC9 score significantly reduces the risk of infertility. This will provide a new avenue for infertility prevention and management, offering hope and potential relief to infertile patients. CI - Copyright (c) 2025 Huang, Duan, Choi and Gong. FAU - Huang, Shaoqun AU - Huang S AD - Department of Oncology Surgery, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China. FAU - Duan, Shuqin AU - Duan S AD - Department of Obstetrics and Gynaecology, The Second Hospital of Jilin University, Changchun, Jilin, China. FAU - Choi, Seok AU - Choi S AD - Department of Physiology, College of Medicine, Chosun University, Gwangju, Republic of Korea. FAU - Gong, Hongyang AU - Gong H AD - Department of Physiology, College of Medicine, Chosun University, Gwangju, Republic of Korea. LA - eng PT - Journal Article DEP - 20250130 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - Female MH - Adult MH - United States/epidemiology MH - Young Adult MH - Nutrition Surveys MH - Adolescent MH - Middle Aged MH - *Infertility, Female/epidemiology/prevention & control MH - *Life Style MH - Cross-Sectional Studies MH - Prevalence PMC - PMC11823206 OTO - NOTNLM OT - Life's Crucial 9 OT - National Health and Nutrition Examination Survey OT - association OT - cardiovascular health OT - infertility COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/02/14 06:20 MHDA- 2025/02/14 06:21 PMCR- 2025/01/01 CRDT- 2025/02/14 04:26 PHST- 2024/07/15 00:00 [received] PHST- 2025/01/15 00:00 [accepted] PHST- 2025/02/14 06:21 [medline] PHST- 2025/02/14 06:20 [pubmed] PHST- 2025/02/14 04:26 [entrez] PHST- 2025/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2025.1465022 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2025 Jan 30;16:1465022. doi: 10.3389/fendo.2025.1465022. eCollection 2025. PMID- 39947662 OWN - NLM STAT- MEDLINE DCOM- 20250213 LR - 20260827 IS - 1099-1611 (Electronic) IS - 1057-9249 (Print) IS - 1057-9249 (Linking) VI - 34 IP - 2 DP - 2025 Feb TI - The Prevalence and Associated Factors of Cancer-Related Worries in Adult Survivors of Childhood Cancer: A Systematic Review. PG - e70101 LID - 10.1002/pon.70101 [doi] LID - e70101 AB - BACKGROUND: Many childhood cancer survivors (CCS) experience cancer-related worries (CRW), for example about late effects and cancer recurrence. CRW are associated with lower quality of life (QoL) and maladaptive health care use. We examined the prevalence, severity, and factors associated with CRW in adult CCS. METHODS: We included quantitative studies of >/= 100 participants reporting on prevalence, severity, mean scores and/or associated factors of CRW among CCS aged >/= 18 years, diagnosed at /= 2 years post-diagnosis. We searched MEDLINE/PubMed and APA PsycINFO, hand-searched reference lists, and consulted experts. Risk of bias was assessed using the Cochrane Childhood Cancer Risk of Bias Criteria. Results were synthesized descriptively. RESULTS: The 17 included studies with a total of 26,306 CCS identified three main themes of CRW: health-related, financial, and interpersonal. Most prevalent were health-related worries regarding future health (88%-92%), late effects (83%), cancer recurrence (25%-88%), second cancers (50%-91%), and infertility (34%-68%). Factors associated with increased CRW varied depending on the specific CRW. These included female sex, more pain, anxiety, depression, chronic conditions (e.g., neurologic, being overweight), and treatment history (chemotherapy, radiotherapy). DISCUSSION AND IMPLICATIONS: Although most included studies used single items to assess CRW, this review underscores that health-related worries are particularly prevalent among CCS. Effectively identifying CCS at high risk, for example through using validated measures, and addressing severe CRW can facilitate adaptive healthcare use and improve QoL among CCS. Potential interventions can be providing information about late effects, psycho-education, discussions during follow-up care, and targeted psychosocial support for those with severe CRW. CI - (c) 2025 The Author(s). Psycho-Oncology published by John Wiley & Sons Ltd. FAU - Maas, Anne AU - Maas A AUID- ORCID: 0000-0001-7835-1802 AD - Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands. FAU - Westerweel, Anne AU - Westerweel A AD - Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands. FAU - Maurice-Stam, Heleen AU - Maurice-Stam H AUID- ORCID: 0000-0002-2055-3230 AD - Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands. FAU - Kremer, Leontien C M AU - Kremer LCM AD - Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands. AD - Department of Pediatrics, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. FAU - van der Aa-van Delden, Alied M AU - van der Aa-van Delden AM AD - Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands. FAU - Zwerus, Daniel AU - Zwerus D AD - Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands. AD - University Medical Center Utrecht, Utrecht, The Netherlands. AD - Wilhelmina Children's Hospital, Utrecht, The Netherlands. FAU - van Dalen, Elvira C AU - van Dalen EC AD - Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands. FAU - Grootenhuis, Martha A AU - Grootenhuis MA AD - Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands. LA - eng GR - Stichting Kinderen Kankervrij/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Systematic Review PL - England TA - Psychooncology JT - Psycho-oncology JID - 9214524 SB - IM MH - Humans MH - *Neoplasms/psychology MH - Prevalence MH - Quality of Life/psychology MH - Adult MH - *Anxiety/epidemiology/psychology MH - *Cancer Survivors/psychology MH - Child MH - Female MH - *Survivors/psychology MH - Male PMC - PMC11825232 OTO - NOTNLM OT - cancer OT - cancer-related worries OT - childhood cancer survivors OT - fear of cancer recurrence OT - financial worries OT - health-related worries OT - interpersonal worries OT - oncology OT - psycho-oncology OT - systematic review COIS- The authors declare no conflicts of interest. EDAT- 2025/02/14 00:24 MHDA- 2025/02/14 00:25 PMCR- 2025/02/14 CRDT- 2025/02/13 20:42 PHST- 2025/01/27 00:00 [revised] PHST- 2024/09/24 00:00 [received] PHST- 2025/01/29 00:00 [accepted] PHST- 2025/02/14 00:25 [medline] PHST- 2025/02/14 00:24 [pubmed] PHST- 2025/02/13 20:42 [entrez] PHST- 2025/02/14 00:00 [pmc-release] AID - PON70101 [pii] AID - 10.1002/pon.70101 [doi] PST - ppublish SO - Psychooncology. 2025 Feb;34(2):e70101. doi: 10.1002/pon.70101. PMID- 39947242 OWN - NLM STAT- MEDLINE DCOM- 20250425 LR - 20260829 IS - 1678-4782 (Electronic) IS - 0021-7557 (Print) IS - 0021-7557 (Linking) VI - 101 IP - 3 DP - 2025 May-Jun TI - Development of a YouthFit Index to assess health-related quality of life in Hong Kong children. PG - 416-423 LID - S0021-7557(25)00020-8 [pii] LID - 10.1016/j.jped.2025.01.004 [doi] AB - OBJECTIVE: To develop a YouthFit Index, a comprehensive and easily interpretable measure of youth health-related quality of life (HRQoL). METHOD: A repeated cross-sectional design was employed to develop and validate the YouthFIt index using the Pediatric Quality of Life Inventory (PedsQL). Activity level and sleep data were collected by a wearable device, Actigraph. Questionnaires were used to gather demographic information and PedsQL data. Multiple-factor analysis of mixed data was employed to identify principal components (PCs) of the modifiable lifestyle variables. The YouthFit Index was calculated by summing the weighted PCs. Logistic regression models were used to assess the odds ratios for risks associated with the YouthFIt Index. RESULTS: A total of 1,867 students were recruited for the study. The findings showed that having YouthFit Index scores greater than 5 was significantly associated with a lower risk of identifying with special health care needs. Compared to the group with YouthFit Index scores below or equal to 5, the group with scores above the cut-off demonstrated a significant 43 % reduction in the risk of PedsQL total score. The results also revealed that increased sleep duration and physical activity are associated with better HRQoL, while longer sedentary periods and later bedtimes are linked to worse HRQoL. CONCLUSIONS: The YouthFit Index is a user-friendly tool for assessing the HRQoL of Hong Kong Chinese children between the ages of 6 and 17. It can help raise awareness about healthy quality of life and promote health and well-being among children in Hong Kong. CI - Copyright (c) 2025 The Authors. Published by Elsevier Editora Ltda. All rights reserved. FAU - Yip, Ka-Man AU - Yip KM AD - The University of Hong Kong, Department of Paediatrics and Adolescent Medicine, Hong Kong SAR, China. FAU - So, Hung-Kwan AU - So HK AD - The University of Hong Kong, Department of Paediatrics and Adolescent Medicine, Hong Kong SAR, China. FAU - Tse, Andy C Y AU - Tse ACY AD - The Education University of Hong Kong, Department of Health and Physical Education, Hong Kong SAR, China. FAU - Tso, Winnie W Y AU - Tso WWY AD - The University of Hong Kong, Department of Paediatrics and Adolescent Medicine, Hong Kong SAR, China. FAU - Siu, Parco M F AU - Siu PMF AD - The University of Hong Kong, School of Public Health, Hong Kong SAR, China. FAU - Wong, Ian C K AU - Wong ICK AD - Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, China; Aston School of Pharmacy, Aston University, Birmingham, UK. FAU - Yam, Jason C AU - Yam JC AD - The Chinese University of Hong Kong, Department of Ophthalmology and Visual Sciences, Hong Kong SAR, China. FAU - Kwan, Mike Y W AU - Kwan MYW AD - Princess Margaret Hospital, Department of Paediatrics and Adolescent Medicine, Hong Kong SAR, China. FAU - Louie, Lobo H T AU - Louie LHT AD - The Education University of Hong Kong, Department of Health and Physical Education, Hong Kong SAR, China. FAU - Wong, Wilfred H S AU - Wong WHS AD - The University of Hong Kong, Department of Paediatrics and Adolescent Medicine, Hong Kong SAR, China. FAU - Ip, Patrick AU - Ip P AD - The University of Hong Kong, Department of Paediatrics and Adolescent Medicine, Hong Kong SAR, China; Hong Kong Children's Hospital, Department of Paediatrics and Adolescent Medicine, Hong Kong SAR, China. Electronic address: patricip@hku.hk. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250212 PL - Brazil TA - J Pediatr (Rio J) JT - Jornal de pediatria JID - 2985188R SB - IM MH - Humans MH - *Quality of Life/psychology MH - Hong Kong MH - Male MH - Cross-Sectional Studies MH - Female MH - Child MH - Surveys and Questionnaires MH - Adolescent MH - *Exercise/physiology MH - Sleep/physiology MH - Life Style MH - Reproducibility of Results PMC - PMC12039373 OTO - NOTNLM OT - Children OT - HRQoL OT - Index OT - MFA OT - Physical fitness OT - Sleep COIS- Conflicts of interest The authors declare no conflicts of interest. EDAT- 2025/02/14 00:24 MHDA- 2025/04/25 06:28 PMCR- 2025/02/12 CRDT- 2025/02/13 19:21 PHST- 2024/05/22 00:00 [received] PHST- 2024/12/01 00:00 [revised] PHST- 2025/01/11 00:00 [accepted] PHST- 2025/04/25 06:28 [medline] PHST- 2025/02/14 00:24 [pubmed] PHST- 2025/02/13 19:21 [entrez] PHST- 2025/02/12 00:00 [pmc-release] AID - S0021-7557(25)00020-8 [pii] AID - 10.1016/j.jped.2025.01.004 [doi] PST - ppublish SO - J Pediatr (Rio J). 2025 May-Jun;101(3):416-423. doi: 10.1016/j.jped.2025.01.004. Epub 2025 Feb 12. PMID- 39947145 OWN - NLM STAT- MEDLINE DCOM- 20251002 LR - 20260319 IS - 1421-9972 (Electronic) IS - 1021-7762 (Linking) VI - 77 IP - 5 DP - 2025 TI - Validation of an Arabic Questionnaire to Assess Pediatric Behavioral Feeding Disorders. PG - 454-463 LID - 10.1159/000543945 [doi] AB - INTRODUCTION: Behavioral feeding assessment allows for identifying the nature and the cause of abnormal feeding behaviors during mealtime, making prognostic predictions, and creating effective treatment plans. This study aimed to develop and validate an Arabic questionnaire to assess abnormal feeding behaviors among Arabic-speaking children. METHODS: Mansoura Pediatric Eating Assessment Scale (MPEAS) was developed and administered to the parents of 100 Arabic-speaking children aged 1-5, including 50 typically developing children without feeding problems and 50 children with abnormal feeding behaviors. The scale includes 40 items in four subdomains (feeding skills, mealtime circumstances, child behavior, and parent behavior). Scoring was based on a 4-point Likert scale, with lower scores indicating greater impairment. Standardized procedures were used to develop and validate the MPEAS, including the items generation phase, pilot study, validation, and reliability testing. RESULTS: MPEAS demonstrated excellent validity (face, content, discriminant, predictive, and convergent) and reliability. CONCLUSION: MPEAS is a valid, reliable, and easily applicable tool for assessing behavioral feeding problems in Arabic-speaking children. This sensitive and specific tool has the potential to significantly improve the screening and treatment of behavioral feeding problems among Arabic-speaking children, offering hope for better outcomes. CI - (c) 2025 S. Karger AG, Basel. FAU - Abou-Elsaad, Tamer AU - Abou-Elsaad T FAU - Helal, Yasmein AU - Helal Y AD - Phoniatrics Unit, ORL Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. FAU - Kadri, Elham AU - Kadri E AD - Phoniatrics Unit, ORL Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. FAU - Afsah, Omayma AU - Afsah O AD - Phoniatrics Unit, ORL Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt. FAU - Abou-Elsaad, Tamer AU - Abou-Elsaad T AD - Phoniatrics Unit, ORL Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt. LA - eng PT - Journal Article PT - Validation Study DEP - 20250213 PL - Switzerland TA - Folia Phoniatr Logop JT - Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP) JID - 9422792 SB - IM MH - Humans MH - Surveys and Questionnaires MH - Male MH - Female MH - Child, Preschool MH - Reproducibility of Results MH - *Feeding and Eating Disorders of Childhood/diagnosis/psychology MH - Infant MH - Psychometrics/statistics & numerical data MH - Arabs MH - Pilot Projects MH - Language MH - Feeding Behavior OTO - NOTNLM OT - Behavioral issues OT - Feeding OT - Pediatrics OT - Questionnaire OT - Reliability OT - Validation EDAT- 2025/02/14 00:23 MHDA- 2025/10/02 18:27 CRDT- 2025/02/13 18:24 PHST- 2024/09/17 00:00 [received] PHST- 2025/01/30 00:00 [accepted] PHST- 2025/10/02 18:27 [medline] PHST- 2025/02/14 00:23 [pubmed] PHST- 2025/02/13 18:24 [entrez] AID - 000543945 [pii] AID - 10.1159/000543945 [doi] PST - ppublish SO - Folia Phoniatr Logop. 2025;77(5):454-463. doi: 10.1159/000543945. Epub 2025 Feb 13. PMID- 39946063 OWN - NLM STAT- MEDLINE DCOM- 20250507 LR - 20250507 IS - 1573-2568 (Electronic) IS - 0163-2116 (Print) IS - 0163-2116 (Linking) VI - 70 IP - 4 DP - 2025 Apr TI - A Score to Predict Advanced Colorectal Neoplasia in Adults Younger than Age 45. PG - 1511-1520 LID - 10.1007/s10620-025-08861-y [doi] AB - BACKGROUND: Early-onset colorectal cancer (CRC) requires identifying adults at heightened risk of advanced colorectal neoplasia (AN) who may warrant colonoscopy initiation < age 45 years. AIMS: We aim to develop and validate a model estimating the likelihood of AN in adults age < 45 years. METHODS: We performed a cross-sectional analysis of adults' ages 18-44 years who underwent a colonoscopy between 2011 and 2021 at a tertiary center. Subjects with AN constituted the case group while those with a normal colonoscopy or non-advanced neoplasia (NAN) formed the control group. We used backward elimination multivariable logistic regression methods to construct a model based on significant associations (p < 0.05) between risk factors and the presence of AN in a randomly selected training set and confirmed the associations in a validation set. RESULTS: AN was detected in 346 (3.7%) of the 9,446 participants included. The reduced logistic regression model based on the training set identified BMI (p = 0.0157), family history of CRC (first-degree relative < 60, p < 0.0001; other family history of CRC p = 0.0117), and tobacco use (current vs. never, p = 0.0015, former vs. never, p = 0.0009) as risk factors for AN. In the validation set, the model exhibited moderate discriminatory power (c-statistic 0.645). The prediction score estimated the likelihood of detecting AN in the complete dataset, from 1.8% for individuals scoring 1 to > 14% for individuals scoring >/= 9. CONCLUSION: We developed and internally validated a simple score using clinical factors which successfully predicts the likelihood of AN in adults < 45 years undergoing colonoscopy. Once externally validated, the proposed risk score may be useful for individualized CRC screening strategies. CI - (c) 2025. The Author(s). FAU - Wehbe, Sarah AU - Wehbe S AD - Gastroenterology and Hepatology, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA. FAU - Thomas, Raj Jessica AU - Thomas RJ AD - Department of Internal Medicine, Cleveland Clinic Akron General, Akron, OH, USA. FAU - Bolwell, Jacquelyn AU - Bolwell J AD - Gastroenterology and Hepatology, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA. FAU - Butler, Robert AU - Butler R AD - Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA. FAU - Burke, Carol A AU - Burke CA AD - Gastroenterology and Hepatology, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA. AD - Young Onset Colorectal Cancer Center, Digestive Disease and Surgery Institute, A30 Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA. AD - Colorectal Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA. FAU - Liska, David AU - Liska D AD - Young Onset Colorectal Cancer Center, Digestive Disease and Surgery Institute, A30 Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA. AD - Colorectal Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA. FAU - Macaron, Carole AU - Macaron C AD - Gastroenterology and Hepatology, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA. Macaroc@ccf.org. AD - Young Onset Colorectal Cancer Center, Digestive Disease and Surgery Institute, A30 Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA. Macaroc@ccf.org. LA - eng PT - Journal Article DEP - 20250213 PL - United States TA - Dig Dis Sci JT - Digestive diseases and sciences JID - 7902782 SB - IM MH - Humans MH - *Colorectal Neoplasms/diagnosis/epidemiology/pathology MH - Adult MH - Male MH - Female MH - Cross-Sectional Studies MH - Colonoscopy MH - Young Adult MH - Risk Factors MH - *Early Detection of Cancer/methods MH - Adolescent MH - Risk Assessment MH - Age Factors MH - Predictive Value of Tests MH - Logistic Models PMC - PMC11972222 OTO - NOTNLM OT - Early-onset advanced neoplasia OT - Early-onset colorectal cancer OT - Risk factors OT - Risk prediction score OT - Screening COIS- Declarations. Conflict of interest: The authors declare no competing interests. EDAT- 2025/02/13 12:27 MHDA- 2025/04/05 16:32 PMCR- 2025/02/13 CRDT- 2025/02/13 11:24 PHST- 2024/10/03 00:00 [received] PHST- 2025/01/09 00:00 [accepted] PHST- 2025/04/05 16:32 [medline] PHST- 2025/02/13 12:27 [pubmed] PHST- 2025/02/13 11:24 [entrez] PHST- 2025/02/13 00:00 [pmc-release] AID - 10.1007/s10620-025-08861-y [pii] AID - 8861 [pii] AID - 10.1007/s10620-025-08861-y [doi] PST - ppublish SO - Dig Dis Sci. 2025 Apr;70(4):1511-1520. doi: 10.1007/s10620-025-08861-y. Epub 2025 Feb 13. PMID- 39943927 OWN - NLM STAT- MEDLINE DCOM- 20250507 LR - 20250507 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 14 DP - 2025 TI - A preliminary study on the reference intervals of vitamin K in some areas of Beijing with normal physical examination population. PG - e15 LID - 10.1017/jns.2025.1 [doi] LID - e15 AB - The vitamin K (VK) levels vary greatly among different populations and in different regions. Currently, there is a lack of reference intervals for VK levels in healthy individuals, The aim of this study is to establish and validate the reference intervals of serum vitamin K1 (VK1) and vitamin K2 (VK2, specifically including menaquinone-4 (MK4) and menaquinone-7 (MK7)) levels in some healthy populations in Beijing. Serum VK1, MK4, and MK7 were firstly measured by high-performance liquid chromatography and mass spectrometry in 434 subjects. The reference intervals for three indicators were established by calculating the data of 2.5 and 97.5 percentiles. Finally, preliminary clinical validation was conducted on 60 apparent healthy individuals undergoing physical examination. In the young, middle-aged, and elderly groups, the reference intervals of VK1 were 0.180 ng/mL approximately 1.494 ng/mL, 0.247 ng/mL approximately 1.446 ng/mL, and 0.167 ng/mL approximately 1.445 ng/mL, respectively. The reference intervals of MK4 were 0.009 ng/mL approximately 0.115 ng/mL, 0.002 ng/mL approximately 0.103 ng/mL, and 0.003 ng/mL approximately 0.106 ng/mL, respectively. The reference intervals of MK7 were 0.169 ng/mL approximately 0.881 ng/mL, 0.238 ng/mL approximately 0.936 ng/mL, and 0.213 ng/mL approximately 1.012 ng/mL, respectively. The reference intervals had been validated by the samples of healthy individuals for physical examination. In conclusion, the reference intervals of VK established in this study with different age groups have certain clinical applicability, providing data support for further multicentre studies. CI - (c) The Author(s) 2025. FAU - Chen, Lin AU - Chen L AD - Clinical Laboratory, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. FAU - Chen, Meiqi AU - Chen M AD - Clinical Laboratory, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. FAU - Cheng, Shi AU - Cheng S AD - Clinical Laboratory, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. FAU - Fei, Jiaxin AU - Fei J AD - Clinical Laboratory, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. FAU - Xu, Dan AU - Xu D AD - Clinical Laboratory, Guang'anmen Hospital, South District, China Academy of Chinese Medical Sciences, Beijing, China. FAU - Hou, Xueyun AU - Hou X AD - Clinical Laboratory, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. FAU - Li, Nannan AU - Li N AD - Clinical Laboratory, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. FAU - Yuan, Yuliang AU - Yuan Y AD - Clinical Laboratory, Guang'anmen Hospital, South District, China Academy of Chinese Medical Sciences, Beijing, China. FAU - Liu, Guijian AU - Liu G AD - Clinical Laboratory, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. FAU - An, Cheng AU - An C AD - Clinical Laboratory, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. LA - eng PT - Journal Article DEP - 20250205 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 RN - 11032-49-8 (Vitamin K 2) RN - 84-80-0 (Vitamin K 1) RN - 12001-79-5 (Vitamin K) RN - 8427BML8NY (menaquinone 7) RN - 27Y876D139 (menatetrenone) SB - IM MH - Humans MH - Reference Values MH - Male MH - Middle Aged MH - Female MH - Adult MH - Beijing MH - Aged MH - *Vitamin K 2/blood/analogs & derivatives MH - Young Adult MH - *Vitamin K 1/blood MH - *Vitamin K/blood MH - Physical Examination MH - Chromatography, High Pressure Liquid MH - Adolescent PMC - PMC11811856 OTO - NOTNLM OT - ALT, alanine aminotransferase OT - AST, aspartate aminotransferase OT - Apparent normal population OT - BMI, body mass index OT - Cr, creatinine OT - FG, fasting glucose OT - HDL-C, high-density lipoprotein cholesterol OT - Hb, haemoglobin OT - LDL-C, low-density lipoprotein cholesterol OT - MK4, Menaquinone-4 OT - MK7, Menaquinone-7 OT - Nutritional status OT - Reference interval OT - Serum level OT - TC, cholesterol OT - TG, triglycerides OT - UA, uric acid OT - VK1, Vitamin K1 OT - Vitamin K OT - ng/ml, nanograms per millilitre COIS- The authors declare no conflict of interest. EDAT- 2025/02/13 11:00 MHDA- 2025/02/13 11:01 PMCR- 2025/01/01 CRDT- 2025/02/13 04:23 PHST- 2024/07/07 00:00 [received] PHST- 2024/12/05 00:00 [revised] PHST- 2024/12/19 00:00 [accepted] PHST- 2025/02/13 11:01 [medline] PHST- 2025/02/13 11:00 [pubmed] PHST- 2025/02/13 04:23 [entrez] PHST- 2025/01/01 00:00 [pmc-release] AID - S2048679025000011 [pii] AID - 10.1017/jns.2025.1 [doi] PST - epublish SO - J Nutr Sci. 2025 Feb 5;14:e15. doi: 10.1017/jns.2025.1. eCollection 2025. PMID- 39943925 OWN - NLM STAT- MEDLINE DCOM- 20250507 LR - 20260823 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 14 DP - 2025 TI - Prevalence of daily fruit and vegetable intake by socio-economic characteristics, women's empowerment, and climate zone: an ecological study in Latin American cities. PG - e4 LID - 10.1017/jns.2024.93 [doi] LID - e4 AB - This cross-sectional ecological study described fruit and vegetable (F&V) intake variability across 144 cities in 8 Latin American countries and by city-level contextual variables. Data sources came from health surveys and census data (Argentina, Brazil, Chile, Colombia, El Salvador, Guatemala, Mexico, and Peru). Self-reported frequency of F&V intake was harmonised across surveys. Daily F&V intake was considered as consumption 7 d of the week. Using a mixed-effects model, we estimated age and sex-standardised city prevalences of daily F&V intake. Through Kruskal-Wallis tests, we compared city F&V daily intake prevalence by tertiles of city variables related to women's empowerment, socio-economics, and climate zones. The median prevalence for daily F&V intake was 55.7% across all cities (22.1% to 85.4%). Compared to the least favourable tertile of city conditions, F&V daily intake prevalence was higher for cities within the most favourable tertile of per capita GDP (median = 65.7% vs. 53.0%), labour force participation (median = 68.7% vs. 49.4%), women achievement-labour force score (median = 63.9% vs. 45.7%), and gender inequality index (median = 58.6% vs. 48.6%). Also, prevalences were higher for temperate climate zones than arid climate zones (median = 65.9% vs. 50.6%). No patterns were found by city level of educational attainment, city size, or population density. This study provides evidence that the prevalence of daily F&V intake varies across Latin American cities and may be favoured by higher socio-economic development, women's empowerment, and temperate weather. Interventions to improve F&V intake in Latin America should consider the behaviour disparities related to underlying local social, economic, and climate zone characteristics. CI - (c) The Author(s) 2025. FAU - Valentino, Giovanna AU - Valentino G AD - Programa de Doctorado, Escuela de Salud Publica, Facultad de Medicina, Universidad de Chile, Santiago, Chile. AD - Departamento de Nutricion y Dietetica, Escuela de Ciencias de la Salud, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile. FAU - Auchincloss, Amy H AU - Auchincloss AH AUID- ORCID: 0000-0002-5844-6721 AD - Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA, USA. AD - Urban Health Collaborative, Dornsife School of Public Health, Drexel University, Philadelphia, PA, USA. FAU - Acharya, Binod AU - Acharya B AD - Urban Health Collaborative, Dornsife School of Public Health, Drexel University, Philadelphia, PA, USA. FAU - Tumas, Natalia AU - Tumas N AUID- ORCID: 0000-0003-4730-6624 AD - Centro de Investigaciones y Estudios sobre Cultura y Sociedad, Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) y Universidad Nacional de Cordoba, Cordoba, Argentina. AD - Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Cordoba, Argentina. FAU - Lopez-Olmedo, Nancy AU - Lopez-Olmedo N AD - Center for Population Health Research, National Institute of Public Health, Cuernavaca, Mexico. FAU - Ortigoza, Ana AU - Ortigoza A AD - Urban Health Collaborative, Dornsife School of Public Health, Drexel University, Philadelphia, PA, USA. AD - Department of Social and Environmental Determinants for Heath Equity, Pan American Health Organization, Washington, DC, USA. FAU - de Menezes, Mariana Carvalho AU - de Menezes MC AUID- ORCID: 0000-0002-3069-7959 AD - Department of Nutrition, Federal University of Minas Gerais, Belo Horizonte, Brazil. FAU - Kroker-Lobos, Maria Fernanda AU - Kroker-Lobos MF AD - INCAP Research Center for the Prevention of Chronic Diseases, Institute of Nutrition of Central America and Panama, Guatemala City, Guatemala. FAU - Nazzal, Carolina AU - Nazzal C AD - Escuela de Salud Publica, Facultad de Medicina, Universidad de Chile, Santiago, Chile. LA - eng GR - 205177/Z/16/Z/WT_/Wellcome Trust/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250115 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 SB - IM MH - Humans MH - Female MH - *Fruit MH - *Vegetables MH - *Socioeconomic Factors MH - Adult MH - Latin America MH - Cross-Sectional Studies MH - Middle Aged MH - Cities MH - *Diet/statistics & numerical data MH - *Climate MH - Young Adult MH - Prevalence MH - *Empowerment MH - Adolescent PMC - PMC11811847 OTO - NOTNLM OT - CI, confidence interval OT - Climate zone OT - Diet quality OT - F&V, Fruits and vegetables OT - GDP, gross domestic product OT - GII, Gender Inequality Index OT - ICC, intraclass correlation coefficient OT - IQR, interquartile range OT - Latin America OT - Middle-income countries OT - SALURBAL, Salud Urbana en America Latina OT - Socio-economic development OT - T, tertile OT - WA, Women Achievement score OT - Women's empowerment COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/02/13 11:01 MHDA- 2025/02/13 11:02 PMCR- 2025/01/01 CRDT- 2025/02/13 04:23 PHST- 2024/07/02 00:00 [received] PHST- 2024/11/14 00:00 [revised] PHST- 2024/12/19 00:00 [accepted] PHST- 2025/02/13 11:02 [medline] PHST- 2025/02/13 11:01 [pubmed] PHST- 2025/02/13 04:23 [entrez] PHST- 2025/01/01 00:00 [pmc-release] AID - S2048679024000934 [pii] AID - 10.1017/jns.2024.93 [doi] PST - epublish SO - J Nutr Sci. 2025 Jan 15;14:e4. doi: 10.1017/jns.2024.93. eCollection 2025. PMID- 39940442 OWN - NLM STAT- MEDLINE DCOM- 20250507 LR - 20250507 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 3 DP - 2025 Feb 5 TI - Nutrition Knowledge, Food Insecurity, and Dietary Biomarkers: Examining Fruit and Vegetable Intake Among College Students. LID - 10.3390/nu17030584 [doi] LID - 584 AB - OBJECTIVES: Food insecurity among college students, combined with limited nutrition knowledge and barriers to healthy eating, significantly impacts diet quality and fruit and vegetable intake. Efforts to address these issues are further complicated by the challenges of accurately and efficiently collecting dietary data in research settings. This study aimed to explore the relationship between nutrition knowledge and fruit/vegetable intake using skin, plasma, and dietary carotenoid levels as biomarkers. METHODS: Undergraduate and graduate students aged 18 years and older (n = 166) from a California public university were recruited. The sample was predominately female (n = 133, 80%), with 30 males (18%) and three individuals (2%) identifying as non-binary. Food security was assessed using the USDA's 10-item Adult Food Security Survey Module and nutrition knowledge through a validated questionnaire. Biological data included blood samples and skin carotenoid measurements (Veggie Meter((R))). Dietary quality (HEI-2015) and carotenoid intake were assessed through Diet ID, a photo-based assessment tool. RESULTS: The mean nutrition knowledge scores were 36.55 +/- 8.83 out of 58 points, and the mean skin carotenoid score was 307.07 +/- 110.22. Higher knowledge scores were associated with increased plasma carotenoids, HEI-score, and Diet ID total carotenoids. Food security classification did not significantly impact nutrition knowledge but did influence HEI scores and skin carotenoid levels, with very low food security linked to poorer diet quality and lower carotenoid levels. CONCLUSIONS: Nutrition knowledge may serve as a significant predictor of fruit and vegetable intake in university students. Despite this correlation, the impact of overall diet quality is potentially hindered by an individual's food security status. Therefore, while knowledge is critical, addressing food insecurity is essential for enhancing diet quality among college students. FAU - Sklar, Emily AU - Sklar E AUID- ORCID: 0000-0001-6832-9118 AD - Department of Nutrition, University of California, Davis, CA 95616, USA. FAU - Radtke, Marcela D AU - Radtke MD AUID- ORCID: 0000-0003-2045-8492 AD - Department of Epidemiology and Population Health, Stanford School of Medicine, Stanford University, Palo Alto, CA 94304, USA. FAU - Steinberg, Francene M AU - Steinberg FM AUID- ORCID: 0000-0003-1856-1503 AD - Department of Nutrition, University of California, Davis, CA 95616, USA. FAU - Medici, Valentina AU - Medici V AUID- ORCID: 0000-0001-5438-284X AD - Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of California, Davis, CA 95616, USA. FAU - Fetter, Deborah S AU - Fetter DS AUID- ORCID: 0000-0002-8531-9760 AD - Department of Nutrition, University of California, Davis, CA 95616, USA. FAU - Scherr, Rachel E AU - Scherr RE AUID- ORCID: 0000-0002-9962-5726 AD - Family, Interiors, Nutrition & Apparel Department, San Francisco State University, 1600 Holloway Avenue, San Francisco, CA 94132, USA. AD - Scherr Nutrition Science Consulting, San Francisco, CA 94115, USA. LA - eng GR - N/A/Diet ID/ GR - CA-D-NTR-6316-H/USDA/ GR - N/A/Aggie Compass/ GR - N/A/University of California Office of the President Global Food Initiative/ PT - Journal Article DEP - 20250205 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) RN - 36-88-4 (Carotenoids) SB - IM MH - Humans MH - Female MH - Male MH - *Fruit MH - *Vegetables MH - *Students/psychology MH - Young Adult MH - Biomarkers/blood MH - *Health Knowledge, Attitudes, Practice MH - Carotenoids/blood/analysis MH - Universities MH - Adult MH - *Food Insecurity MH - *Diet MH - Adolescent MH - Nutritional Status MH - Diet, Healthy MH - California PMC - PMC11819945 OTO - NOTNLM OT - carotenoids OT - college students OT - dietary assessment OT - food insecurity OT - fruit and vegetable intake OT - nutrition knowledge COIS- The author Rachel E. Scherr was employed by the Scherr Nutrition Science Consulting company. All authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2025/02/13 11:00 MHDA- 2025/02/13 11:01 PMCR- 2025/02/05 CRDT- 2025/02/13 01:02 PHST- 2025/01/17 00:00 [received] PHST- 2025/01/31 00:00 [revised] PHST- 2025/02/03 00:00 [accepted] PHST- 2025/02/13 11:01 [medline] PHST- 2025/02/13 11:00 [pubmed] PHST- 2025/02/13 01:02 [entrez] PHST- 2025/02/05 00:00 [pmc-release] AID - nu17030584 [pii] AID - nutrients-17-00584 [pii] AID - 10.3390/nu17030584 [doi] PST - epublish SO - Nutrients. 2025 Feb 5;17(3):584. doi: 10.3390/nu17030584. PMID- 39940352 OWN - NLM STAT- MEDLINE DCOM- 20250213 LR - 20250516 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 3 DP - 2025 Jan 29 TI - Dietary Lipid Profile in Spanish Children with Overweight or Obesity: A Longitudinal Study on the Impact of Children's Eating Behavior and Sedentary Habits. LID - 10.3390/nu17030494 [doi] LID - 494 AB - BACKGROUND: Dietary lipids, sedentary habits, and eating behaviors influence childhood obesity, but their interrelations remain unclear. AIM: To assess the relationships between young children's dietary lipid profile and children's eating behavior, as well as their sedentary habits, providing evidence-based insights that can help mitigate obesity risk in this vulnerable population. DESIGN: A longitudinal randomized controlled trial conducted over 9 months, involving 90 children aged 2-6 years with overweight or obesity who were followed under a program that promoted healthy lifestyle habits for all participants and regularly monitored their parameters. METHODS: The dietary lipid profile, eating behavior, and sedentary habits were assessed at baseline and after 9 months using validated tools, including 24 h recalls, the child eating behavior questionnaire (CEBQ), and screen time questionnaires. RESULTS: Reductions in screen/sedentary time were significantly associated with decreased total fat (-11.1 g/day) and saturated fat (-4.3 g/day) intake, compared to smaller reductions in unchanged screen hours and increases with prolonged screen use. A positive correlation was observed between changes in dietary fat and the CEBQ domain "Desire to drink" (r = 0.528, p < 0.001), with regression analysis confirming a direct relationship. CONCLUSIONS: Managing screen time and eating behavior is crucial for improving dietary lipid profile and reducing childhood obesity risk. Strategies should include reducing sedentary behaviors, limiting sugary drinks, and promoting water as the main beverage, alongside effective nutrition education for families. FAU - Garcia, Silvia AU - Garcia S AUID- ORCID: 0000-0003-3534-1588 AD - Research Group on Community Nutrition & Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - CIBEROBN (Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, 28029 Madrid, Spain. AD - Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain. FAU - Rodenas-Munar, Marina AU - Rodenas-Munar M AD - Research Group on Community Nutrition & Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - CIBEROBN (Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, 28029 Madrid, Spain. AD - Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain. FAU - Argelich, Emma AU - Argelich E AD - Research Group on Community Nutrition & Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain. FAU - Mateos, David AU - Mateos D AD - Research Group on Community Nutrition & Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain. FAU - Ugarriza, Lucia AU - Ugarriza L AD - Research Group on Community Nutrition & Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - CIBEROBN (Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, 28029 Madrid, Spain. AD - Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain. AD - Camp Redo Primary Health Care Center, 07010 Palma de Mallorca, Spain. FAU - Tur, Josep A AU - Tur JA AUID- ORCID: 0000-0002-6940-0761 AD - Research Group on Community Nutrition & Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - CIBEROBN (Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, 28029 Madrid, Spain. AD - Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain. FAU - Bouzas, Cristina AU - Bouzas C AUID- ORCID: 0000-0002-1407-8461 AD - Research Group on Community Nutrition & Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - CIBEROBN (Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, 28029 Madrid, Spain. AD - Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain. LA - eng GR - 774548 - STOP - H2020-SFS-2016-2017/H2020-SFS-2017-2/Horizon 2020 Program/ GR - CIBEROBN CB12/03/30038/Instituto de Salud Carlos III/ GR - Grants (FOLIUM, PRIMUS, SYNERGIA, and LIBERI/IDISBA/ GR - N/A/European Regional Development Fund/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20250129 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Dietary Fats) RN - 0 (Lipids) SB - IM MH - Humans MH - Child MH - *Sedentary Behavior MH - Longitudinal Studies MH - Female MH - Male MH - *Feeding Behavior MH - *Pediatric Obesity/epidemiology/blood MH - Child, Preschool MH - Spain/epidemiology MH - *Overweight MH - *Dietary Fats/administration & dosage MH - Screen Time MH - *Child Behavior MH - *Lipids/blood PMC - PMC11820457 OTO - NOTNLM OT - childhood obesity OT - dietary lipids OT - eating behavior OT - nutrition education OT - saturated fat OT - screen time COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest. EDAT- 2025/02/13 11:01 MHDA- 2025/02/13 11:02 PMCR- 2025/01/29 CRDT- 2025/02/13 01:01 PHST- 2024/12/14 00:00 [received] PHST- 2025/01/24 00:00 [revised] PHST- 2025/01/28 00:00 [accepted] PHST- 2025/02/13 11:02 [medline] PHST- 2025/02/13 11:01 [pubmed] PHST- 2025/02/13 01:01 [entrez] PHST- 2025/01/29 00:00 [pmc-release] AID - nu17030494 [pii] AID - nutrients-17-00494 [pii] AID - 10.3390/nu17030494 [doi] PST - epublish SO - Nutrients. 2025 Jan 29;17(3):494. doi: 10.3390/nu17030494. PMID- 39940291 OWN - NLM STAT- MEDLINE DCOM- 20250213 LR - 20250728 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 3 DP - 2025 Jan 24 TI - Nutritional Screening Tools in the Pediatric Population: A Systematic Review. LID - 10.3390/nu17030433 [doi] LID - 433 AB - BACKGROUND/OBJECTIVES: Disease-related malnutrition (DRM) is the most common type of malnutrition in industrialized countries, and it has a high associated morbidity. Despite the existence of various screening tools for its detection, there is currently no consensus in the literature on which one is the most appropriate for clinical use. The aim of this systematic review is to update the available evidence on pediatric nutritional screening tools and to compare their validity and applicability. METHODS: A systematic review of the literature was conducted using the MEDLINE (PubMed) database, selecting articles related to nutritional screening tools in the pediatric population. A quality assessment was carried out using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2). RESULTS: A total of 200 articles were identified, of which 11 were included in the review. They include a total of 9,573 patients (mean age of 6.7 years and 49% female) from different countries. Eight screening tools were found, and three of them were the most employed: the Screening Tool for Risk on Nutritional Status and Growth (STRONGkids), the Screening Tool for the Assessment of Malnutrition in Pediatric (STAMP), and the Pediatric Yorkhill Malnutrition Score (PYMS). A high level of heterogeneity was observed among the selected studies without a gold standard for comparison. CONCLUSIONS: Despite the heterogeneity, the PYMS seems to have the greatest capacity to detect pediatric patients at nutritional risk and should therefore be considered when choosing a nutritional screening tool. FAU - Fachal, Carlos Veiga AU - Fachal CV AD - Pediatric Gastroenterology, Hepatology and Nutrition Unit, Department of Pediatrics, A Coruna University Hospital, Area Sanitaria A Coruna-Cee, 15006 A Coruna, Spain. FAU - Fernandez-Gonzalez, Sara Maria AU - Fernandez-Gonzalez SM AUID- ORCID: 0000-0002-9255-5198 AD - Pediatric Gastroenterology, Hepatology and Nutrition Unit, Department of Pediatrics, A Coruna University Hospital, Area Sanitaria A Coruna-Cee, 15006 A Coruna, Spain. FAU - Moreno-Alvarez, Ana AU - Moreno-Alvarez A AUID- ORCID: 0000-0002-7211-1821 AD - Pediatric Gastroenterology, Hepatology and Nutrition Unit, Department of Pediatrics, A Coruna University Hospital, Area Sanitaria A Coruna-Cee, 15006 A Coruna, Spain. FAU - Solar-Boga, Alfonso AU - Solar-Boga A AUID- ORCID: 0000-0003-2606-3790 AD - Pediatric Gastroenterology, Hepatology and Nutrition Unit, Department of Pediatrics, A Coruna University Hospital, Area Sanitaria A Coruna-Cee, 15006 A Coruna, Spain. LA - eng PT - Journal Article PT - Systematic Review DEP - 20250124 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Nutrition Assessment MH - Child MH - Nutritional Status MH - *Mass Screening/methods MH - Female MH - Child, Preschool MH - Male MH - *Malnutrition/diagnosis MH - *Child Nutrition Disorders/diagnosis MH - Reproducibility of Results MH - Infant PMC - PMC11820693 OTO - NOTNLM OT - malnutrition OT - nutritional risk OT - nutritional screening tool OT - pediatric population OT - systematic review COIS- The authors declare no conflicts of interest. EDAT- 2025/02/13 11:01 MHDA- 2025/02/13 11:02 PMCR- 2025/01/24 CRDT- 2025/02/13 01:01 PHST- 2024/12/10 00:00 [received] PHST- 2025/01/02 00:00 [revised] PHST- 2025/01/16 00:00 [accepted] PHST- 2025/02/13 11:02 [medline] PHST- 2025/02/13 11:01 [pubmed] PHST- 2025/02/13 01:01 [entrez] PHST- 2025/01/24 00:00 [pmc-release] AID - nu17030433 [pii] AID - nutrients-17-00433 [pii] AID - 10.3390/nu17030433 [doi] PST - epublish SO - Nutrients. 2025 Jan 24;17(3):433. doi: 10.3390/nu17030433. PMID- 39939945 OWN - NLM STAT- MEDLINE DCOM- 20250507 LR - 20260609 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 25 IP - 1 DP - 2025 Feb 12 TI - The effectiveness of a transition programme based on the integrated theory of health behavior change in adolescents with chronic kidney disease: a quasi-experimental study. PG - 111 LID - 10.1186/s12887-025-05467-1 [doi] LID - 111 AB - BACKGROUND: To validate the effectiveness of the application of a transition programme for adolescents with chronic kidney disease based on the Integrated Theory of Health Behavior Change. METHODS: This study was a quasi-experiment study. We included 76 adolescents with chronic kidney disease, and based on their willingness to undergo transition intervention, participants were assigned to either the intervention group or the control group. The intervention group received the transition intervention guided by the Integrated Theory of Health Behavior Change, while the control group received standard care and education, remaining unaware of the intervention group's existence. The data of the intervention group were collected before and after the intervention. Because the total intervention lasted approximately 4 weeks, the data of the control group were collected at baseline (T0) and 1 month (T1). We chose transition readiness as the primary outcome. The secondary outcomes included medication adherence and self-efficacy. RESULTS: At the final assessment (T1), the scores related to transition readiness, medication adherence, self-care self-efficacy, and adolescent exercise and eating behavior self-efficacy in the intervention group were significantly higher than those in the control group (P < 0.05). Compared with those at T0, the scores of all the constructs in the intervention group increased at T1, and these differences were statistically significant. There was a weak positive correlation between participants' transition readiness and their medication adherence (r = 0.389, P < 0.01), self-care self-efficacy (r = 0.501, P < 0.01), exercise behavior self-efficacy (r = 0.237, P < 0.05), and eating behavior self-efficacy (r = 0.481, P < 0.01). CONCLUSIONS: Based on the Integrated Theory of Health Behavior Change, the transition program for adolescents with chronic kidney disease significantly improved participants' transition readiness, self-care self-efficacy, and exercise and eating behavior self-efficacy. While the study's design limits definitive conclusions on the program's impact on medication adherence, the observed improvements suggest that potential benefits warrant further investigation. TRIAL REGISTRATION: The study obtained approval from the local institutional review board and was registered on https://www.chictr.org.cn (Clinical Trial Number: ChiCTR2300077149) prior to the enrollment of the first subject on October 31, 2023. CI - (c) 2025. The Author(s). FAU - Yang, Qiaoyue AU - Yang Q AD - Department of Nursing, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095, Jiefang Avenue, Wuhan, China. AD - School of Nursing, Tongji Medical College, Huazhong University of Science and Technology, No.13, Aviation Road, Wuhan, China. FAU - Yu, Genzhen AU - Yu G AD - Department of Nursing, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095, Jiefang Avenue, Wuhan, China. 691007@tjh.tjmu.edu.cn. FAU - Fu, Maoling AU - Fu M AD - Department of Nursing, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095, Jiefang Avenue, Wuhan, China. AD - School of Nursing, Tongji Medical College, Huazhong University of Science and Technology, No.13, Aviation Road, Wuhan, China. FAU - Yang, Juanjuan AU - Yang J AD - Department of Nursing, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095, Jiefang Avenue, Wuhan, China. FAU - Li, Xinyu AU - Li X AD - Department of Nursing, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095, Jiefang Avenue, Wuhan, China. AD - School of Nursing, Tongji Medical College, Huazhong University of Science and Technology, No.13, Aviation Road, Wuhan, China. LA - eng GR - 2022C09/Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Research Fund/ PT - Journal Article DEP - 20250212 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - *Health Behavior MH - *Renal Insufficiency, Chronic/therapy/psychology MH - Self Efficacy MH - Self Care MH - Medication Adherence MH - Exercise MH - *Transition to Adult Care MH - Program Evaluation MH - Adolescent Behavior MH - Feeding Behavior PMC - PMC11823011 OTO - NOTNLM OT - Adolescents OT - Chronic kidney disease OT - Integrated theory of health behavior change OT - Intervention OT - Transition readiness COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology in China, and the methods were carried out in accordance with the approved guidelines. All the patients have been informed and signed informed consent before the experiments. Informed consent was obtained from the parents or legal guardians of all participants under the age of 16, who provided written consent prior to their inclusion in the study. Consent for publication: Consent for publication was obtained from the participants. Competing interests: The authors declare no competing interests. EDAT- 2025/02/13 00:22 MHDA- 2025/02/13 11:00 PMCR- 2025/02/12 CRDT- 2025/02/12 23:55 PHST- 2024/09/13 00:00 [received] PHST- 2025/01/28 00:00 [accepted] PHST- 2025/02/13 11:00 [medline] PHST- 2025/02/13 00:22 [pubmed] PHST- 2025/02/12 23:55 [entrez] PHST- 2025/02/12 00:00 [pmc-release] AID - 10.1186/s12887-025-05467-1 [pii] AID - 5467 [pii] AID - 10.1186/s12887-025-05467-1 [doi] PST - epublish SO - BMC Pediatr. 2025 Feb 12;25(1):111. doi: 10.1186/s12887-025-05467-1. PMID- 39939857 OWN - NLM STAT- MEDLINE DCOM- 20250213 LR - 20250507 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Feb 12 TI - Adaptation and validation of a dietary diversity questionnaire to predict nutrient adequacy in children aged 24 to 59 months in Iran: national food and nutrition surveillance. PG - 576 LID - 10.1186/s12889-025-21772-x [doi] LID - 576 AB - BACKGROUND: Dietary Diversity Score (DDS), as a proxy for nutritional adequacy, can be used as a useful tool to assess diet quality, especially in children, due to its low cost and ease of use in comprehensive studies. This study aimed to develop a questionnaire to estimate dietary diversity and also assess the validity of DDS as an indicator of nutritional status among children aged 24 to 59 months in Iran. METHODS: In addition to the Dietary Diversity Questionnaire (DDQ), which was designed based on the Food and Agriculture Organization (FAO) protocols, two non-consecutive 24-hour dietary recalls were completed for 471 children aged 24-59 months, recruited using random cluster sampling. Nutrient Adequacy Ratio (NAR) for energy, protein, and micronutrients, and the Mean Nutrient Adequacy Ratio (MAR) were calculated. Serum retinol concentration was assayed using High Performance Liquid Chromatography (HPLC). Children's weights and heights were measured and Height for Age (HAZ), Weight for Age (WAZ), Weight for Height (WHZ), and BMI for Age (BAZ) Z-scores were calculated according to World Health Organization (WHO) criteria in 2006. Pearson correlation analysis was performed to analyze the correlation between DDS and NARs, MAR, anthropometric indicators, and serum retinol. RESULTS: The mean age of the children was 42.5 +/- 0.47 months. The average DDS was 5.19 +/- 0.06. DDS showed a positive association with the NAR of energy, protein, and all micronutrients (p < 0.05) except for vitamin K. There was a positive and significant correlation between DDS and MAR (r = 0.271; p < 0.001). In addition, DDS showed a direct, weaker but statistically significant, correlation with serum retinol concentration (r = 0.104; p = 0.026). No significant relationship was found between DDS and children's growth indicators. CONCLUSIONS: The designed DDQ can be a valuable tool for examining the adequacy of nutritional intake in Iranian children. CI - (c) 2025. The Author(s). FAU - Rasekhi, Hamid AU - Rasekhi H AD - Department of Nutrition Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Yari, Zahra AU - Yari Z AD - Department of Nutrition Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Nikooyeh, Bahareh AU - Nikooyeh B AD - Department of Nutrition Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Neyestani, Tirang R AU - Neyestani TR AD - Department of Nutrition Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Ghodsi, Delaram AU - Ghodsi D AD - Department of Nutrition Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Rabiei, Samira AU - Rabiei S AD - Department of Nutrition Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Ebrahimof, Samira AU - Ebrahimof S AD - Department of Nutrition Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Amini, Maryam AU - Amini M AD - Department of Nutrition Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. maramin2002@yahoo.com. LA - eng GR - 01-31851/5-16-2022/Shahid Beheshti University of Medical Sciences, National Nutrition and Food. Technology Research Institute/ PT - Journal Article PT - Validation Study DEP - 20250212 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Iran MH - Female MH - Male MH - Child, Preschool MH - Surveys and Questionnaires/standards MH - *Diet/statistics & numerical data/standards MH - *Nutritional Status MH - *Nutrition Surveys MH - Reproducibility of Results MH - *Nutrition Assessment MH - Infant PMC - PMC11817819 OTO - NOTNLM OT - Children OT - Dietary diversity OT - Nutrients OT - Nutritional adequacy COIS- Declarations. Ethics approval and consent to participate: The Ethical Committees of the National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences approved the study protocol (IR.SBMU.NNFTRI.REC.1401.025) in accordance with the Declaration of Helsinki. All patients signed an informed consent form and the aims and procedures were explained to them. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/02/13 00:22 MHDA- 2025/02/13 11:01 PMCR- 2025/02/12 CRDT- 2025/02/12 23:43 PHST- 2024/08/23 00:00 [received] PHST- 2025/02/04 00:00 [accepted] PHST- 2025/02/13 11:01 [medline] PHST- 2025/02/13 00:22 [pubmed] PHST- 2025/02/12 23:43 [entrez] PHST- 2025/02/12 00:00 [pmc-release] AID - 10.1186/s12889-025-21772-x [pii] AID - 21772 [pii] AID - 10.1186/s12889-025-21772-x [doi] PST - epublish SO - BMC Public Health. 2025 Feb 12;25(1):576. doi: 10.1186/s12889-025-21772-x. PMID- 39938751 OWN - NLM STAT- MEDLINE DCOM- 20250507 LR - 20260528 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 207 DP - 2025 Mar 1 TI - Taming "hanger" and falling prey to boredom-emotional and stress-eating in 801 healthy individuals using ecological momentary assessment. PG - 107897 LID - S0195-6663(25)00049-2 [pii] LID - 10.1016/j.appet.2025.107897 [doi] AB - Emotional eating and Stress Eating concepts hold that affective experiences can instill the desire for palatable foods. The empirical evidence for such couplings between affective and appetitive systems, however, is mixed and it remains unclear which one precedes the other or whether interindividual differences in such relationships exist. To study the temporal relations between a range of negative and positive emotions and stress on the one hand and snacking behavior on the other, we analyzed over 40.000 questionnaire entries obtained through ecological momentary assessment from 801 participants across nine different studies. Several trait-level eating style questionnaire scores were modelled as moderators for the emotion/stress - snacking relationships. Results showed that stronger boredom was followed by more snacking. Only irritation showed the pattern of reduction following snacking that would be predicted by emotion regulation accounts of emotional eating. Restrained eaters showed larger increases in boredom after snacking (compared to not snacking) than unrestrained eaters. Eating style questionnaires did not significantly moderate any other emotion - snacking - emotion relationships. Together with other recent findings from this dataset (Aulbach et al., n.d.) the present results suggest that eating style questionnaires capture tendencies to experience food cravings, but not snacking, as the latter might be 'gated' by several internal and external conditions that our EMA data and the trait questionnaire do not capture well. Accordingly, we suggest a novel terminology for affect-eating relationships that increases precision on the temporal (affects before or after eating/craving) and the phenomenological (snacking, craving) level. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Aulbach, Matthias Burkard AU - Aulbach MB AD - Paris-Lodron-University of Salzburg, Department of Psychology, Centre for Cognitive Neuroscience, Hellbrunner Str. 34, 5020, Salzburg, Austria. Electronic address: Matthias.aulbach@plus.ac.at. FAU - Bamberg, Christoph AU - Bamberg C AD - Paris-Lodron-University of Salzburg, Department of Psychology, Centre for Cognitive Neuroscience, Hellbrunner Str. 34, 5020, Salzburg, Austria. FAU - Reichenberger, Julia AU - Reichenberger J AD - Paris-Lodron-University of Salzburg, Department of Psychology, Centre for Cognitive Neuroscience, Hellbrunner Str. 34, 5020, Salzburg, Austria; Ludwig-Maximilians-University Munich, Department of Psychology, Germany. FAU - Arend, Ann-Kathrin AU - Arend AK AD - Paris-Lodron-University of Salzburg, Department of Psychology, Centre for Cognitive Neuroscience, Hellbrunner Str. 34, 5020, Salzburg, Austria. FAU - Blechert, Jens AU - Blechert J AD - Paris-Lodron-University of Salzburg, Department of Psychology, Centre for Cognitive Neuroscience, Hellbrunner Str. 34, 5020, Salzburg, Austria. LA - eng PT - Journal Article DEP - 20250210 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - *Ecological Momentary Assessment MH - Female MH - Male MH - *Boredom MH - Adult MH - Young Adult MH - *Feeding Behavior/psychology MH - *Emotions MH - Snacks/psychology MH - Surveys and Questionnaires MH - *Stress, Psychological/psychology MH - *Eating/psychology MH - Adolescent MH - Middle Aged MH - Craving OTO - NOTNLM OT - Dietary behavior OT - Eating styles OT - Ecological momentary assessment OT - Emotional eating OT - Questionnaire validation OT - Stress eating COIS- Declaration of competing interest None. EDAT- 2025/02/13 00:22 MHDA- 2025/03/06 05:04 CRDT- 2025/02/12 19:31 PHST- 2024/08/20 00:00 [received] PHST- 2025/01/30 00:00 [revised] PHST- 2025/02/04 00:00 [accepted] PHST- 2025/03/06 05:04 [medline] PHST- 2025/02/13 00:22 [pubmed] PHST- 2025/02/12 19:31 [entrez] AID - S0195-6663(25)00049-2 [pii] AID - 10.1016/j.appet.2025.107897 [doi] PST - ppublish SO - Appetite. 2025 Mar 1;207:107897. doi: 10.1016/j.appet.2025.107897. Epub 2025 Feb 10. PMID- 39935332 OWN - NLM STAT- MEDLINE DCOM- 20250523 LR - 20260913 IS - 1536-4801 (Electronic) IS - 0277-2116 (Linking) VI - 80 IP - 5 DP - 2025 May TI - Development and psychometric validation of a clinical instrument for infant feeding and lifestyle evaluation. PG - 870-879 LID - 10.1002/jpn3.70012 [doi] AB - OBJECTIVE: There is an absence of a comprehensive clinical instrument to assess and track the development of non-ideal feeding practices and lifestyle behaviours in early childhood. Our primary aim was to develop and validate an assessment instrument, called Feeding, Lifestyle, Activity Goals (FLAGs), designed to serve as a feeding, lifestyle and activity behaviour checklist for children aged 0-2 years. METHODS: This study took place between January and May 2023. Experts evaluated content validity using the criteria of relevance, clarity, simplicity and ambiguity, to calculate the item content validity index (I-CVI) and scale CVI (S-CVI) (acceptable cutoff >/= 0.80). Face validity was assessed by caregivers. Repeated assessments were also performed to determine test-retest reliability based on intra-class correlation (ICC) (acceptable cutoff > 0.75). Construct validity was established through principal component analysis (PCA), and internal consistency was measured using Cronbach's alpha coefficient (acceptable cutoff >/= 0.70). RESULTS: FLAGs consists of 19 items, with a I-CVI of 1.00 in 12 out of 19 items, and S-CVI average of >0.90 for relevance, simplicity and clarity. Among 198 caregivers, 99.0% responded 'agree' and 'strongly agree' in the criteria of clarity and ambiguity; 99.5% in criterion of relevance, and 100% in criterion of simplicity. PCA showed a two-component structure (55.9% variance). Overall Cronbach's alpha was 0.71. Participants repeated FLAGs assessment on an average of 9 days apart, with ICC of 0.861 (p < 0.001) for the total FLAGs scores. CONCLUSIONS: We have developed an instrument which assesses an infant's feeding and lifestyle behaviour from 0 to 2 years, and this has been assessed to have acceptable validity and reliability. CI - (c) 2025 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Chan, Daniel AU - Chan D AUID- ORCID: 0000-0001-8191-5330 AD - Endocrinology Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore. AD - Duke-NUS Medical School, Singapore, Singapore. AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. FAU - Lin, Jiaying AU - Lin J AD - Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Zheng, Ruther Teo AU - Zheng RT AD - Endocrinology Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Ong, Chengsi AU - Ong C AD - Department of Nutrition and Dietetics, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Ku, Chee Wai AU - Ku CW AD - Duke-NUS Medical School, Singapore, Singapore. AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, Singapore. AD - SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Loo, Benny Kai Guo AU - Loo BKG AD - Duke-NUS Medical School, Singapore, Singapore. AD - Sports and Exercise Medicine Service, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Chan, Jerry Kok Yen AU - Chan JKY AD - Duke-NUS Medical School, Singapore, Singapore. AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, Singapore. AD - SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Chua, Mei Chien AU - Chua MC AD - Duke-NUS Medical School, Singapore, Singapore. AD - Department of Neonatology, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Yap, Fabian AU - Yap F AD - Endocrinology Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore. AD - Duke-NUS Medical School, Singapore, Singapore. AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. AD - SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Loy, See Ling AU - Loy SL AD - Duke-NUS Medical School, Singapore, Singapore. AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, Singapore. AD - SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore, Singapore. LA - eng GR - KKH-AM/2022/02/KKH Academic Medicine Start-Up Grant/ GR - KKH Health Services Model of Care Transformation Fund, and Lien Foundation Optimizing Maternal and Child Health Program Fund/ GR - NMRC/MOH-000596-00/National Medical Research Council, Ministry of Health, Singapore/ GR - NMRC/CSA-SI-008-2016/National Medical Research Council, Ministry of Health, Singapore/ GR - MOH-001266-01/National Medical Research Council, Ministry of Health, Singapore/ GR - MOH-001221-01/National Medical Research Council, Ministry of Health, Singapore/ GR - MOH-000932-01/National Medical Research Council, Ministry of Health, Singapore/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250211 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM MH - *Psychometrics/standards MH - Humans MH - Male MH - Female MH - Infant, Newborn MH - Infant MH - Child, Preschool MH - *Checklist/standards MH - *Child Behavior/psychology MH - *Feeding Behavior/psychology MH - *Life Style MH - Reproducibility of Results MH - Principal Component Analysis MH - Caregivers/psychology OTO - NOTNLM OT - child health OT - developmental origins of health and disease OT - eating behaviours OT - instrument development OT - validity EDAT- 2025/02/12 06:21 MHDA- 2025/05/12 06:33 CRDT- 2025/02/12 03:03 PHST- 2025/01/12 00:00 [revised] PHST- 2024/07/20 00:00 [received] PHST- 2025/01/28 00:00 [accepted] PHST- 2025/05/12 06:33 [medline] PHST- 2025/02/12 06:21 [pubmed] PHST- 2025/02/12 03:03 [entrez] AID - 10.1002/jpn3.70012 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2025 May;80(5):870-879. doi: 10.1002/jpn3.70012. Epub 2025 Feb 11. PMID- 39935008 OWN - NLM STAT- MEDLINE DCOM- 20250212 LR - 20260924 IS - 2291-9694 (Electronic) IS - 2291-9694 (Linking) VI - 13 DP - 2025 Feb 11 TI - Enhancing Surgery Scheduling in Health Care Settings With Metaheuristic Optimization Models: Algorithm Validation Study. PG - e57231 LID - 10.2196/57231 [doi] LID - e57231 AB - BACKGROUND: Health care is facing many challenges. The recent pandemic has caused a global reflection on how clinical and organizational processes should be organized, which requires the optimization of decision-making among managers and health care professionals to deliver care that is increasingly patient-centered. The efficiency of surgical scheduling is particularly critical, as it affects waiting list management and is susceptible to suboptimal decisions due to its complexity and constraints. OBJECTIVE: In this study, in collaboration with one of the leading hospitals in Portugal, Centro Hospitalar e Universitario de Santo Antonio (CHUdSA), a heuristic approach is proposed to optimize the management of the surgical center. METHODS: CHUdSA's surgical scheduling process was analyzed over a specific period. By testing an optimization approach, the research team was able to prove the potential of artificial intelligence (AI)-based heuristic models in minimizing scheduling penalties-the financial costs incurred by procedures that were not scheduled on time. RESULTS: The application of this approach demonstrated potential for significant improvements in scheduling efficiency. Notably, the implementation of the hill climbing (HC) and simulated annealing (SA) algorithms stood out in this implementation and minimized the scheduling penalty, scheduling 96.7% (415/429) and 84.4% (362/429) of surgeries, respectively. For the HC algorithm, the penalty score was 0 in the urology, obesity, and pediatric plastic surgery medical specialties. For the SA algorithm, the penalty score was 5100 in urology, 1240 in obesity, and 30 in pediatric plastic surgery. Together, this highlighted the ability of AI-heuristics to optimize the efficiency of this process and allowed for the scheduling of surgeries at closer dates compared to the manual method used by hospital professionals. CONCLUSIONS: Integrating these solutions into the surgical scheduling process increases efficiency and reduces costs. The practical implications are significant. By implementing these AI-driven strategies, hospitals can minimize patient wait times, maximize resource use, and enhance surgical outcomes through improved planning. This development highlights how AI algorithms can effectively adapt to changing health care environments, having a transformative impact. CI - (c) Joao Lopes, Tiago Guimaraes, Julio Duarte, Manuel Santos. Originally published in JMIR Medical Informatics (https://medinform.jmir.org). FAU - Lopes, Joao AU - Lopes J AUID- ORCID: 0000-0001-7854-8293 AD - ALGORITMI Research Centre, University of Minho, Rua da Universidade, Braga, 4800-058, Portugal, 351 934373667. FAU - Guimaraes, Tiago AU - Guimaraes T AUID- ORCID: 0000-0001-6320-8878 AD - ALGORITMI Research Centre, University of Minho, Rua da Universidade, Braga, 4800-058, Portugal, 351 934373667. FAU - Duarte, Julio AU - Duarte J AUID- ORCID: 0000-0002-5458-3390 AD - ALGORITMI Research Centre, University of Minho, Rua da Universidade, Braga, 4800-058, Portugal, 351 934373667. FAU - Santos, Manuel AU - Santos M AUID- ORCID: 0000-0002-5441-3316 AD - ALGORITMI Research Centre, University of Minho, Rua da Universidade, Braga, 4800-058, Portugal, 351 934373667. LA - eng PT - Journal Article PT - Validation Study DEP - 20250211 PL - Canada TA - JMIR Med Inform JT - JMIR medical informatics JID - 101645109 SB - IM MH - Humans MH - *Appointments and Schedules MH - *Algorithms MH - *Efficiency, Organizational MH - Portugal MH - Artificial Intelligence MH - Delivery of Health Care/organization & administration PMC - PMC11840878 OTO - NOTNLM OT - artificial intelligence OT - health care OT - metaheuristic model OT - model optimization OT - surgery scheduling OT - surgery scheduling problem COIS- Conflicts of Interest: None declared. EDAT- 2025/02/12 06:21 MHDA- 2025/02/12 06:22 PMCR- 2025/02/11 CRDT- 2025/02/12 00:23 PHST- 2024/02/08 00:00 [received] PHST- 2024/07/09 00:00 [revised] PHST- 2024/07/21 00:00 [accepted] PHST- 2025/02/12 06:22 [medline] PHST- 2025/02/12 06:21 [pubmed] PHST- 2025/02/12 00:23 [entrez] PHST- 2025/02/11 00:00 [pmc-release] AID - v13i1e57231 [pii] AID - 57231 [pii] AID - 10.2196/57231 [doi] PST - epublish SO - JMIR Med Inform. 2025 Feb 11;13:e57231. doi: 10.2196/57231. PMID- 39934783 OWN - NLM STAT- MEDLINE DCOM- 20250507 LR - 20250507 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Feb 11 TI - Health literacy disparities in Thai university students: exploring differences between health science and non-health science disciplines. PG - 557 LID - 10.1186/s12889-025-21761-0 [doi] LID - 557 AB - BACKGROUND: Health literacy (HL) in Thailand remains a significant issue, with a large portion of the population demonstrating limited HL, and limited research exists on specific determinants among Thai university students. Some culture shapes health decision-making and HL disparities within this group, highlighting the need to evaluate HL comprehensively. This study aims to assess and compare HL levels among health science and non-health science students, and identify key predictors associated with HL. METHODS: A cross-sectional study was conducted among 1,647 Thai university students, comprising 676 health science and 971 non-health science students, recruited through multi-stage stratified random sampling. Data were collected using validated questionnaires that measured sociodemographic characteristics, academic background, lifestyle behaviors, and HL levels across three sub-domains, including healthcare, disease prevention, and health promotion. Statistical analyses included univariable and multivariable regression models, with significance set at p-value < 0.05. RESULTS: Health sciences students demonstrated significantly higher HL scores across all sub-domains compared to non-health sciences students. Limited HL was found in 12.6% for health science students, and 28.4% for non-health science students. Key predictors of overall HL included gender, income, faculty of study, and lifestyle-related health behaviors. Female students showed higher total HL (beta = 1.41; 95% CI: 0.62, 2.21), as did those with higher income (beta = 1.28; 95% CI: 0.76, 1.80). Students enrolled in health sciences programs had higher HL scores (beta = 2.86; 95% CI: 2.07, 3.64). Lifestyle behaviors also correlated with HL, with non-smoking (beta = -0.58; 95% CI: -1.03, -0.13), no alcohol consumption (beta = -0.45, 95%CI: -0.89, -0.01), and regular physical activity (beta = 0.35; 95% CI: 0.04, 0.66). Consumption of sweet foods/drinks was inversely related to HL scores (beta = -0.87; 95% CI: -1.49, -0.26). CONCLUSIONS: HL among Thai university students varies significantly by sociodemographic factors, academic background, and lifestyle behaviors. Health sciences students exhibited stronger HL skills, underscoring the importance of integrating health education into non-health sciences curricula. Targeted HL interventions are recommended for non-health sciences students, males, and individuals from lower-income backgrounds to enhance health decision-making and reduce HL disparities. These findings have implications for policy and practice, emphasizing the integration of HL modules into university curricula, health promotion campaigns, and the provision of accessible health services to foster an inclusive and health-literate student population. CI - (c) 2025. The Author(s). FAU - Manochaiwuthikul, Thanyaporn AU - Manochaiwuthikul T AD - Department of Community Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthavaroros Road, Sri Phum Subdistrict, Muang District, Chiang Mai, 50200, Thailand. FAU - Chaichutchouwakul, Amornrat AU - Chaichutchouwakul A AD - Department of Community Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthavaroros Road, Sri Phum Subdistrict, Muang District, Chiang Mai, 50200, Thailand. FAU - Yunan, Nantakarn AU - Yunan N AD - Department of Community Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthavaroros Road, Sri Phum Subdistrict, Muang District, Chiang Mai, 50200, Thailand. FAU - Winothai, Niwarin AU - Winothai N AD - Department of Community Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthavaroros Road, Sri Phum Subdistrict, Muang District, Chiang Mai, 50200, Thailand. FAU - Kanta, Peewara AU - Kanta P AD - Department of Community Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthavaroros Road, Sri Phum Subdistrict, Muang District, Chiang Mai, 50200, Thailand. FAU - Sapbamrer, Ratana AU - Sapbamrer R AUID- ORCID: 0000-0003-0379-2798 AD - Department of Community Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthavaroros Road, Sri Phum Subdistrict, Muang District, Chiang Mai, 50200, Thailand. ratana.sapbamrer@cmu.ac.th. LA - eng GR - 080/2567/Faculty of Medicine, Chiang Mai University/ PT - Journal Article DEP - 20250211 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Thailand MH - Female MH - Male MH - Cross-Sectional Studies MH - Universities MH - *Health Literacy/statistics & numerical data MH - Young Adult MH - *Students/statistics & numerical data/psychology MH - Adult MH - Surveys and Questionnaires MH - Adolescent MH - Southeast Asian People PMC - PMC11817181 OTO - NOTNLM OT - Academic OT - Behavior OT - Health literacy OT - Lifestyle OT - Student OT - University OT - Young adult COIS- Ethics approval and consent to participate: This study was approved by the research Ethics Committee of Faculty of Medicine, Chiang Mai University, Thailand (No.137/2024, Approval date 28 March 2024). Written informed consent was obtained from all participants. The study protocol was carried out according to the relevant guidelines expressed in the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/02/12 00:20 MHDA- 2025/02/12 00:21 PMCR- 2025/02/11 CRDT- 2025/02/11 23:41 PHST- 2024/11/15 00:00 [received] PHST- 2025/02/04 00:00 [accepted] PHST- 2025/02/12 00:21 [medline] PHST- 2025/02/12 00:20 [pubmed] PHST- 2025/02/11 23:41 [entrez] PHST- 2025/02/11 00:00 [pmc-release] AID - 10.1186/s12889-025-21761-0 [pii] AID - 21761 [pii] AID - 10.1186/s12889-025-21761-0 [doi] PST - epublish SO - BMC Public Health. 2025 Feb 11;25(1):557. doi: 10.1186/s12889-025-21761-0. PMID- 39934647 OWN - NLM STAT- MEDLINE DCOM- 20250506 LR - 20260803 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Feb 12 TI - Genomic correlation, shared loci, and causal association between obesity, periodontitis and tooth loss. PG - 5155 LID - 10.1038/s41598-025-89782-8 [doi] LID - 5155 AB - Observational studies have reported an association of obesity with periodontitis and tooth loss, yet findings remain inconsistent. We aim to investigate the genetic link underlying obesity-related traits (BMI [body mass index], WHR [waist-to-hip ratio], WHR(adj)BMI and childhood BMI), periodontitis and tooth loss. Leveraging summary statistics from large-scale genome-wide association studies, we comprehensively investigated the pair-wise genetic correlation using linkage disequilibrium score regression (LDSC) and SUPERGNOVA, identified shared loci using cross-phenotype association analysis (CPASSOC), and estimated causal association using Mendelian randomization. We identified a significant genetic correlation of obesity with tooth loss, but not with periodontitis. Partitioning the genome into LD-independent regions revealed 10 significantly shared local signals across six regions. Genome-wide cross-trait analysis uncovered 14 shared loci, four of which were colocalized: rs2064044 (PP4 = 0.94), rs6000329 (PP4 = 0.86), rs7134628 (PP4 = 0.86), and rs1286769 (PP4 = 0.90). Notably, rs1286769, identified via CPASSOC and validated through colocalization analysis, is located near RARbeta, a gene associated with both BMI and denture use. Mendelian randomization revealed a nominally-significant causal association of obesity with periodontitis (P = 0.045) but a robust causal association with tooth loss represented by number of teeth (BMI: beta = [Formula: see text]0.20, 95%CI = [Formula: see text]0.26 to [Formula: see text]0.14, P = 5.27 x 10(-11); WHR: beta = [Formula: see text]0.16, 95%CI = [Formula: see text]0.24 to [Formula: see text]0.08, P = 3.71 x 10(-5)). Results of CAUSE were consistent with main findings. From a genetic perspective, our work highlights an intrinsic link between obesity, periodontitis and tooth loss, which may add new lines of evidence and provide insights for clinical and public oral health applications. CI - (c) 2025. The Author(s). FAU - Chen, Lin AU - Chen L AD - Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, China. FAU - Qu, Yang AU - Qu Y AD - Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, China. FAU - Cui, Huijie AU - Cui H AD - Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, China. FAU - Zhang, Wenqiang AU - Zhang W AD - Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, China. FAU - Wu, Xuan AU - Wu X AD - Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, China. FAU - Zhao, Xunying AU - Zhao X AD - Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, China. FAU - Xiao, Jinyu AU - Xiao J AD - Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, China. FAU - Tang, Mingshuang AU - Tang M AD - Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, China. FAU - Wang, Yutong AU - Wang Y AD - Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, China. FAU - Zou, Yanqiu AU - Zou Y AD - Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, China. FAU - Qiu, Lingli AU - Qiu L AD - Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, China. FAU - Tan, Zhixin AU - Tan Z AD - Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, China. FAU - Lei, Bowen AU - Lei B AD - Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, China. FAU - Ma, Xiaofeng AU - Ma X AD - Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, China. FAU - Zhang, Di AU - Zhang D AD - Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, China. FAU - Liu, Yunjie AU - Liu Y AD - Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, China. FAU - Fan, Mengyu AU - Fan M AD - Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, China. FAU - Li, Jiayuan AU - Li J AD - Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, China. FAU - Zhang, Ben AU - Zhang B AD - Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, China. benzhang@vip.163.com. AD - Departments of Cardiology, Neurology, and Oncology, Hainan General Hospital and Hainan Affiliated Hospital, Hainan Medical University, Haikou, China. benzhang@vip.163.com. AD - Department of Occupational and Environmental Health, West China School of Public Health, West China Fourth Hospital, Sichuan University, Chengdu, China. benzhang@vip.163.com. FAU - Jiang, Xia AU - Jiang X AD - Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, China-PUMC C. C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, China. xiajiang@scu.edu.cn. AD - Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. xiajiang@scu.edu.cn. AD - Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden. xiajiang@scu.edu.cn. LA - eng PT - Journal Article DEP - 20250212 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Obesity/genetics/complications MH - *Tooth Loss/genetics MH - *Periodontitis/genetics MH - Genome-Wide Association Study MH - *Genetic Predisposition to Disease MH - Body Mass Index MH - Polymorphism, Single Nucleotide MH - Linkage Disequilibrium MH - Mendelian Randomization Analysis MH - Genomics MH - Male MH - Female MH - Phenotype PMC - PMC11814315 OTO - NOTNLM OT - Genetic correlation OT - Mendelian randomization OT - Obesity OT - Periodontitis OT - Pleiotropic loci COIS- Declarations. Ethics approval and consent to participate: The GWAS summary statistics utilized in this study are publicly accessible aggregate data that do not include any personal identifiers. The original GWAS studies had already secured the necessary ethical approval from the appropriate review boards. Competing interests: The authors declare no competing interests. EDAT- 2025/02/12 00:20 MHDA- 2025/02/12 00:21 PMCR- 2025/02/12 CRDT- 2025/02/11 23:36 PHST- 2024/09/13 00:00 [received] PHST- 2025/02/07 00:00 [accepted] PHST- 2025/02/12 00:21 [medline] PHST- 2025/02/12 00:20 [pubmed] PHST- 2025/02/11 23:36 [entrez] PHST- 2025/02/12 00:00 [pmc-release] AID - 10.1038/s41598-025-89782-8 [pii] AID - 89782 [pii] AID - 10.1038/s41598-025-89782-8 [doi] PST - epublish SO - Sci Rep. 2025 Feb 12;15(1):5155. doi: 10.1038/s41598-025-89782-8. PMID- 39934274 OWN - NLM STAT- MEDLINE DCOM- 20250211 LR - 20260803 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Feb 11 TI - Relationship between dietary inflammatory index and metabolic dysfunction associated steatotic liver disease in children. PG - 5081 LID - 10.1038/s41598-025-89690-x [doi] LID - 5081 AB - Emerging research suggests a connection between dietary habits and metabolic dysfunction associated steatotic liver disease (MASLD). We aimed to assess the relationship between the Dietary Inflammatory Index (DII) and the severity of MASLD. This cross-sectional study involved 125 participants aged 7-18 with MASLD. Dietary intakes were assessed using a validated 147-item food frequency questionnaire. The DII was applied to measure diet-induced inflammation, categorizing diets into anti-inflammatory (DII < -1) and inflammatory diets (DII > + 1). To evaluate hepatic steatosis and fibrosis, transabdominal ultrasonography and the fibrosis-4 (FIB-4) index were utilized. After adjusting for potential confounding factors, individuals on inflammatory diets exhibited a significantly higher odds ratio (OR) for experiencing more severe steatosis (OR: 4.11; 95% CI: 1.08-15.71) compared to those on anti-inflammatory diets. Furthermore, each unit increase in DII scores was linked to a 2.6-fold increase in the odds of more severe steatosis (OR: 2.61; 95% CI: 1.28-5.32) and a 0.006 increase in FIB-4 scores (beta: 0.006; 95% CI: 0.003-0.011). In conclusion, modifying dietary intakes to lower DII scores may be a beneficial approach to improving clinical outcomes in pediatric MASLD, as anti-inflammatory diets are associated with reduced severity of hepatic steatosis and fibrosis. CI - (c) 2025. The Author(s). FAU - Amiri, Fateme AU - Amiri F AD - Department of Nutritional Sciences, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran. FAU - Moludi, Jalal AU - Moludi J AD - Department of Nutritional Sciences, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran. FAU - Jouybari, Touraj Ahmadi AU - Jouybari TA AD - Clinical Research Development Center, Imam Khomeini and Mohammad Kermanshahi and Farabi Hospitals, Kermanshah University of Medical Sciences, Kermanshah, Iran. FAU - Ghasemi, Mahmoud AU - Ghasemi M AD - Department of Pediatrics, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. FAU - Sharifi, Maryam AU - Sharifi M AD - Department of Nutritional Sciences, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran. FAU - Mahaki, Behzad AU - Mahaki B AD - Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. FAU - Soleimani, Davood AU - Soleimani D AD - Department of Nutritional Sciences, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran. Nut.davood@gmail.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250211 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM EIN - Sci Rep. 2025 Apr 28;15(1):14910. doi: 10.1038/s41598-025-00087-2. PMID: 40295508 MH - Humans MH - Male MH - Female MH - Child MH - Adolescent MH - *Inflammation/etiology MH - Cross-Sectional Studies MH - *Diet/adverse effects MH - *Fatty Liver/metabolism/etiology/pathology MH - Severity of Illness Index MH - Liver Cirrhosis PMC - PMC11814066 OTO - NOTNLM OT - Diet OT - Fibrosis OT - Inflammation OT - Non-alcoholic fatty liver disease OT - Pediatrics COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: The study was approved by the ethics committee of Kermanshah University of Medical Sciences (IR.KUMS.REC.1401.564). Informed consent was obtained from the child's parent or legal guardian. Additionally, children who were able to understand the study's aims and procedures provided their assent. This study was conducted in accordance with the principles of the Helsinki Declaration. Consent for publication: Consent is available for publication. EDAT- 2025/02/12 00:20 MHDA- 2025/02/12 00:21 PMCR- 2025/02/11 CRDT- 2025/02/11 23:21 PHST- 2024/09/25 00:00 [received] PHST- 2025/02/06 00:00 [accepted] PHST- 2025/02/12 00:21 [medline] PHST- 2025/02/12 00:20 [pubmed] PHST- 2025/02/11 23:21 [entrez] PHST- 2025/02/11 00:00 [pmc-release] AID - 10.1038/s41598-025-89690-x [pii] AID - 89690 [pii] AID - 10.1038/s41598-025-89690-x [doi] PST - epublish SO - Sci Rep. 2025 Feb 11;15(1):5081. doi: 10.1038/s41598-025-89690-x. PMID- 39933396 OWN - NLM STAT- MEDLINE DCOM- 20250507 LR - 20250507 IS - 1873-264X (Electronic) IS - 0731-7085 (Linking) VI - 258 DP - 2025 Jun 15 TI - Widely targeted plasma lipidomic analysis of Term Low Birth Weight Infants: unraveling signatures and implications for early growth patterns. PG - 116732 LID - S0731-7085(25)00073-1 [pii] LID - 10.1016/j.jpba.2025.116732 [doi] AB - Low birth weight is recognized as a risk factor for adult metabolic and cardiovascular diseases. This study investigates whether term low birth weight (TLBW) neonates, who have been exposed to unfavorable settings, demonstrate compromised lipid metabolism. A widely targeted lipidomic analysis was conducted using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) on 59 plasma samples (28 TLBW and 31 term normal birth weight (TNBW) neonates. We conducted univariate and multivariate analyses to identify differential lipids. Spearman's correlation coefficient assessed the association between lipid content at birth and Z-scores for the subsequent physical growth of enrolled children. A total of 1523 lipids in 36 subcategories across 6 major categories were detected. 269 differential lipids were discerned, with 114 up-regulated and 155 down-regulated. In the TLBW group, we observed higher levels of sphingomyelins (including SM(d18:1/16:1), SM(d18:2/23:1), SM(d18:1/22:0), and SM(d18:2/24:1)), Hex3Cer(d18:1/16:0), as well as phosphatidylcholines (PC(O-14:0_20:4) and PC(O-16:0_20:4)), and cholesterol esters (CE (20:4)). In contrast, phosphatidylethanolamines (PE) such as PE (18:2_22:1), PE (18:1_22:1), and triglyceride (TG(10:0_16:2_18:2)) were lower. The KEGG enrichment analysis revealed a consistent alteration in both sphingolipid metabolism and steroid biosynthesis. Moreover, PC(O-16:0_20:4), Hex3Cer(d18:1/16:0), and CE(20:4) exhibited positive correlations with the Z-score of height-for-age at follow-up, while PE(O-18:1_24:4) and PS(20:2_22:4) showed negative correlations with the Z-score of weight-for-age. Our findings reveal novel lipidomic differences between TLBW and TNBW neonates. The observed lipid variations at birth, including sphingomyelins and glycerophospholipids, could affect subsequent growth. Further studies are needed to validate these findings in diverse populations, address confounding factors, and investigate underlying mechanisms. CI - Copyright (c) 2025 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Liu, Jing AU - Liu J AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China. FAU - Sun, Qi AU - Sun Q AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China. FAU - Tang, Lijuan AU - Tang L AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China. FAU - Lv, Di AU - Lv D AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China. FAU - Chen, Yuanmei AU - Chen Y AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China. FAU - Ye, Fang AU - Ye F AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China. FAU - Liu, Die AU - Liu D AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China. FAU - Liang, Haixiao AU - Liang H AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China. FAU - Wang, Chao AU - Wang C AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China. FAU - Zhang, Qi AU - Zhang Q AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China. Electronic address: zhangqikeyan@163.com. LA - eng PT - Journal Article DEP - 20250206 PL - England TA - J Pharm Biomed Anal JT - Journal of pharmaceutical and biomedical analysis JID - 8309336 RN - 0 (Lipids) SB - IM MH - Humans MH - *Lipidomics/methods MH - Infant, Newborn MH - Female MH - Tandem Mass Spectrometry/methods MH - *Lipids/blood MH - Male MH - *Infant, Low Birth Weight/blood/growth & development MH - Lipid Metabolism/physiology MH - Chromatography, High Pressure Liquid/methods MH - Birth Weight/physiology OTO - NOTNLM OT - Lipidomics OT - Sphingomyelins OT - TLBW OT - Term low birth weight OT - UPLC-MS/MS COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/02/12 00:20 MHDA- 2025/03/09 15:10 CRDT- 2025/02/11 18:08 PHST- 2024/11/17 00:00 [received] PHST- 2025/01/15 00:00 [revised] PHST- 2025/02/02 00:00 [accepted] PHST- 2025/03/09 15:10 [medline] PHST- 2025/02/12 00:20 [pubmed] PHST- 2025/02/11 18:08 [entrez] AID - S0731-7085(25)00073-1 [pii] AID - 10.1016/j.jpba.2025.116732 [doi] PST - ppublish SO - J Pharm Biomed Anal. 2025 Jun 15;258:116732. doi: 10.1016/j.jpba.2025.116732. Epub 2025 Feb 6. PMID- 39932941 OWN - NLM STAT- MEDLINE DCOM- 20250507 LR - 20261008 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 2 DP - 2025 TI - Assessing physical literacy and establishing normative reference curves for 8-12-year-old children from South Punjab, Pakistan: The PAK-IPPL cross-sectional study. PG - e0312916 LID - 10.1371/journal.pone.0312916 [doi] LID - e0312916 AB - BACKGROUND: Physical literacy (PL) encompasses an individual's motivation, confidence, physical competence, and knowledge, all of which foster lifelong engagement in physical activities. In developing countries like Pakistan, there is a pressing need to assess PL status using culturally valid tools. This study aims to evaluate PL among children aged 8-12 in South Punjab, Pakistan while developing normative reference curves and exploring factors influencing PL. METHODS: A cross-sectional study was conducted with 1,360 students (mean age = 10.00, SD = 1.41 years) from 85 schools, using a culturally adapted and validated version of the CAPL-2 tool. The CAPL-2 scoring system was validated to align with the population and cultural context. Statistical analyses, including t-tests, Chi-squared tests, Pearson's correlation, multivariate logistic regression, and Classification and regression tree methods, were performed to identify factors associated with PL classifications, with significance set at p < 0.05. The Generalized Additive Models for Location, Scale, and Shape were used to create age- and sex-specific PL normative reference curves. RESULT: The study revealed significant influences of gender, socioeconomic status (SES), and locality on PL. Boys consistently scored higher in PL across all domains compared to girls, with significant differences (p < 0.001) in all but the knowledge and understanding domain (p = 0.160). Boys' PL scores were 6% higher overall, with a 7% and 5% advantage in the daily behavior and physical competence domains, respectively. Children from low SES and rural settings exhibited significantly higher PL scores than their middle/high SES and urban counterparts (p < 0.001). Walking to school was positively correlated with higher PL scores, while children traveling by car had the lowest scores (p < 0.001). Anthropometric differences between genders were noted, further emphasizing the disparities in physical competence. Most participants (71.6%) fell into the "Beginning" or "Progressing" PL categories, with females predominantly in these lower stages. CONCLUSION: This study reveals that gender, SES, and locality significantly impact PL among children in South Punjab, Pakistan. Boys, lower SES groups, and rural children showed higher PL scores, with everyday activities like walking to school positively contributing to PL development. These findings emphasize the need for targeted, demographically sensitive interventions to enhance PL in the region. CI - Copyright: (c) 2025 Hadier et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Hadier, Syed Ghufran AU - Hadier SG AUID- ORCID: 0000-0001-5164-5886 AD - School of Physical Education, Shanxi University, Taiyuan, Shanxi Province, China. AD - Department of Sports Sciences, Bahauddin Zakariya University, Multan, Punjab, Pakistan. FAU - Yinghai, Liu AU - Yinghai L AD - School of Physical Education, Shanxi University, Taiyuan, Shanxi Province, China. FAU - Long, Liu AU - Long L AD - School of Physical Education, Suzhou University, Suzhou, Anhui, China. FAU - Hamdani, Syed Danish AU - Hamdani SD AD - Division of Olympic Sports, China Swimming College, Beijing Sport University, Beijing, China. AD - School Education Department, Government of Punjab, Multan, Pakistan. FAU - Hamdani, Syed Muhammad Zeeshan Haider AU - Hamdani SMZH AUID- ORCID: 0000-0001-7632-0869 AD - Faculty of Social Science, Department of Sports Sciences, Bahauddin Zakariya University, Multan, Punjab, Pakistan. LA - eng PT - Journal Article DEP - 20250211 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Male MH - Pakistan MH - Female MH - Cross-Sectional Studies MH - Child MH - Reference Values MH - *Literacy MH - Exercise PMC - PMC11813120 COIS- The authors have declared that no competing interests exist. EDAT- 2025/02/11 18:22 MHDA- 2025/02/11 18:23 PMCR- 2025/02/11 CRDT- 2025/02/11 13:34 PHST- 2024/02/14 00:00 [received] PHST- 2024/10/15 00:00 [accepted] PHST- 2025/02/11 18:23 [medline] PHST- 2025/02/11 18:22 [pubmed] PHST- 2025/02/11 13:34 [entrez] PHST- 2025/02/11 00:00 [pmc-release] AID - PONE-D-24-03589 [pii] AID - 10.1371/journal.pone.0312916 [doi] PST - epublish SO - PLoS One. 2025 Feb 11;20(2):e0312916. doi: 10.1371/journal.pone.0312916. eCollection 2025. PMID- 39932587 OWN - NLM STAT- MEDLINE DCOM- 20250507 LR - 20261010 IS - 1436-6215 (Electronic) IS - 1436-6207 (Linking) VI - 64 IP - 2 DP - 2025 Feb 11 TI - Dietary patterns, nutrients, and risk of expiratory airflow limitation in children and adolescents. PG - 85 LID - 10.1007/s00394-025-03604-1 [doi] AB - BACKGROUND: Increasing global pediatric respiratory diseases require understanding modifiable factors affecting lung function. We explored the association between dietary patterns, nutrients and the risk of expiratory airflow limitation (EAL) in children and adolescents. METHODS: Dietary intake was collected using a validated food frequency questionnaire (FFQ) with 110 food items. Factor analysis was employed to determine dietary patterns. Pulmonary function was measured using a medical-grade pulmonary function analyzer. EAL was defined as the ratio of Forced Expiratory Volume in one second to Forced Vital Capacity (FEV(1)/FVC) < 0.8. RESULTS: A total of 611 EAL cases occurred in 3,204 participants, with a prevalence of 19.07%. Four primary dietary patterns were identified (animal, healthy, sweet, and plant foods), which explained 44% of the variance in food consumption. The plant foods pattern (fourth quartile vs. first quartile intake) was associated with a reduced risk of EAL (Odds Ratio [OR] = 0.71, 95% Confidence Interval [CI]: 0.53, 0.94; P(for trend) < 0.02). Higher fruit consumption (high vs. low) in plant foods pattern was associated with lower EAL risk (OR = 0.79, 95% CI: 0.62, 0.99, P(for trend) = 0.04). Every standard deviation increase in foods (Chinese sauerkraut, pickled foods) and nutrients (total dietary fiber, soluble dietary fiber, and pyridoxine) in plant foods was all positively associated with FEV(1) /FVC (all P < 0.05). CONCLUSIONS: Long-term intake of plant foods pattern enriched with dietary fiber and pyridoxine is promising for lung function protection in children and adolescents. CI - (c) 2025. Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Bao, Yijing AU - Bao Y AD - Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Shenyang, 110004, Liaoning, China. AD - Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, No. 36, Sanhao Street, Shenyang, 110004, Liaoning, China. FAU - Chang, Qing AU - Chang Q AD - Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Shenyang, 110004, Liaoning, China. AD - Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, No. 36, Sanhao Street, Shenyang, 110004, Liaoning, China. FAU - Zhang, Han AU - Zhang H AD - Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Ding, Huiyuan AU - Ding H AD - Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Shenyang, 110004, Liaoning, China. AD - Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, No. 36, Sanhao Street, Shenyang, 110004, Liaoning, China. FAU - Gao, Jing AU - Gao J AD - Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Shenyang, 110004, Liaoning, China. AD - Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, No. 36, Sanhao Street, Shenyang, 110004, Liaoning, China. FAU - Zhang, Chuyang AU - Zhang C AD - Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Shenyang, 110004, Liaoning, China. AD - Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, No. 36, Sanhao Street, Shenyang, 110004, Liaoning, China. FAU - Chi, Baofeng AU - Chi B AD - Inner Mongolia Medical University, Inner Mongolia, China. FAU - Xia, Yang AU - Xia Y AD - Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Shenyang, 110004, Liaoning, China. AD - Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, No. 36, Sanhao Street, Shenyang, 110004, Liaoning, China. FAU - Zhao, Yuhong AU - Zhao Y AUID- ORCID: 0000-0002-6806-521X AD - Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Shenyang, 110004, Liaoning, China. yhzhaosj_hospital@126.com. AD - Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, No. 36, Sanhao Street, Shenyang, 110004, Liaoning, China. yhzhaosj_hospital@126.com. FAU - Zhang, Hehua AU - Zhang H AD - Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Shenyang, 110004, Liaoning, China. sj_zhanghh@126.com. AD - Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, No. 36, Sanhao Street, Shenyang, 110004, Liaoning, China. sj_zhanghh@126.com. AD - Clinical Trials and Translation Center, Shengjing Hospital of China Medical University, Shenyang, China. sj_zhanghh@126.com. LA - eng GR - M0287/345 Talent Project of Shengjing Hospital of China Medical University/ GR - 82103791/The National Natural Science Foundation of China/ GR - 2021JH1/1040050/JieBangGuaShuai Project of Liaoning Province/ PT - Journal Article DEP - 20250211 PL - Germany TA - Eur J Nutr JT - European journal of nutrition JID - 100888704 RN - 0 (Nutrients) SB - IM MH - Humans MH - Child MH - Adolescent MH - Male MH - Female MH - *Diet/methods MH - *Nutrients/administration & dosage MH - Forced Expiratory Volume MH - Risk Factors MH - Cross-Sectional Studies MH - Vital Capacity MH - Respiratory Function Tests OTO - NOTNLM OT - Children and adolescent OT - Expiratory airflow limitation OT - FEV1 OT - Nutrient OT - Plant foods pattern COIS- Declarations. Ethics approval: The Institutional Review Board at Shengjing Hospital, affiliated with China Medical University, provided approval for the study protocol (No. 2017PS190K). Competing interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/02/11 12:23 MHDA- 2025/02/11 12:24 CRDT- 2025/02/11 11:15 PHST- 2024/08/14 00:00 [received] PHST- 2025/01/31 00:00 [accepted] PHST- 2025/02/11 12:24 [medline] PHST- 2025/02/11 12:23 [pubmed] PHST- 2025/02/11 11:15 [entrez] AID - 10.1007/s00394-025-03604-1 [pii] AID - 10.1007/s00394-025-03604-1 [doi] PST - epublish SO - Eur J Nutr. 2025 Feb 11;64(2):85. doi: 10.1007/s00394-025-03604-1. PMID- 39931536 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250212 IS - 1178-6965 (Print) IS - 1178-6965 (Electronic) IS - 1178-6965 (Linking) VI - 18 DP - 2025 TI - The Joint Association of Sleep Quality and Outdoor Activity with Asthma and Allergic Rhinitis in Children: A Cross-Sectional Study in Shanghai. PG - 101-111 LID - 10.2147/JAA.S494662 [doi] AB - PURPOSE: Aiming to investigate the combined association of sleep quality and outdoor activity with the risk of asthma and allergic rhinitis in children. PATIENTS AND METHODS: 16,936 children from kindergartens and primary schools in 13 administrative districts of Shanghai, China were involved in the analyses. The Children's Sleep Habits Questionnaire (CSHQ) and the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire were respectively used to evaluate the sleep quality, allergic rhinitis and asthma. Multivariable logistic regression models were used to analyze the correlation of sleep quality, outdoor activities and their combination with children's asthma and allergic rhinitis. RESULTS: The overall prevalence of asthma and allergic rhinitis in our sampled children were 10.2% and 17.6%, respectively. Poor sleep quality (asthma: aOR, 1.45; 95% CI: 1.23 to 1.73; allergic rhinitis: aOR, 1.16; 95% CI: 1.03 to 1.31) and low outdoor activity (asthma: aOR, 1.30; 95% CI: 1.14 to 1.49, allergic rhinitis: aOR, 1.18; 95% CI: 1.07 to 1.32) were separately associated with higher risk of asthma and allergic rhinitis, and when the two were superimposed, an additive effect (asthma: aOR, 1.76; 95% CI: 1.30 to 2.39; allergic rhinitis: aOR, 1.46; 95% CI: 1.17 to 1.82) was revealed. These associations were independent of sleep duration, but being stronger in sleep sufficiency group. And after stratification by gender, premature birth and family history of allergy, similar associations were validated in general. CONCLUSION: Poor sleep quality and low levels of outdoor activity, when combined, have a stronger association with asthma and allergic rhinitis than each factor independently, and this relationship is not influenced by sleep duration. Our findings highlight the need for public health interventions that simultaneously address multiple lifestyle factors to reduce the risk of allergic diseases. CI - (c) 2025 Lu et al. FAU - Lu, Ruoyu AU - Lu R AD - School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China. FAU - Zhang, Ye AU - Zhang Y AD - School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China. FAU - Chen, Yiting AU - Chen Y AD - School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China. FAU - Lyu, Jiajun AU - Lyu J AD - School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China. FAU - Li, Rong AU - Li R AD - School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China. FAU - Kang, Wenhui AU - Kang W AD - School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China. FAU - Zhao, Anda AU - Zhao A AD - School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China. AD - Huadong Hospital, Fudan University, Shanghai, People's Republic of China. FAU - Ning, Zidi AU - Ning Z AD - School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China. FAU - Hu, Yabin AU - Hu Y AD - National Children's Medical Center, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China. FAU - Lin, Xiaya AU - Lin X AD - Hainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, Hainan Province, People's Republic of China. FAU - Tong, Shilu AU - Tong S AUID- ORCID: 0000-0001-9579-6889 AD - National Children's Medical Center, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China. FAU - Lu, Zhaohui AU - Lu Z AD - National Children's Medical Center, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China. FAU - Li, Shenghui AU - Li S AUID- ORCID: 0000-0002-2687-2697 AD - School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China. AD - MOE-Shanghai Key Laboratory of Children's Environmental Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China. LA - eng PT - Journal Article DEP - 20250204 PL - New Zealand TA - J Asthma Allergy JT - Journal of asthma and allergy JID - 101543450 PMC - PMC11807787 OTO - NOTNLM OT - allergic rhinitis OT - asthma OT - physical activity OT - sleep quality COIS- The authors report no conflicts of interest in this work. EDAT- 2025/02/11 06:21 MHDA- 2025/02/11 06:22 PMCR- 2025/02/04 CRDT- 2025/02/11 04:21 PHST- 2024/10/03 00:00 [received] PHST- 2024/12/10 00:00 [accepted] PHST- 2025/02/11 06:22 [medline] PHST- 2025/02/11 06:21 [pubmed] PHST- 2025/02/11 04:21 [entrez] PHST- 2025/02/04 00:00 [pmc-release] AID - 494662 [pii] AID - 10.2147/JAA.S494662 [doi] PST - epublish SO - J Asthma Allergy. 2025 Feb 4;18:101-111. doi: 10.2147/JAA.S494662. eCollection 2025. PMID- 39930819 OWN - NLM STAT- MEDLINE DCOM- 20250806 LR - 20250808 IS - 1911-9828 (Electronic) IS - 0008-4174 (Print) IS - 0008-4174 (Linking) VI - 92 IP - 3 DP - 2025 Sep TI - Exploring occupational therapists' use of movement guidelines for young children with disabilities. PG - 185-195 LID - 10.1177/00084174251318200 [doi] AB - Background. Children with developmental disabilities are less likely than their peers without disabilities to meet the Canadian 24-Hour Movement Guidelines which provide daily recommendations for time spent in physical activity, sedentary behaviour, and sleep. Occupational Therapists (OTs) are well-positioned to support the engagement of preschoolers with developmental disabilities in movement but little is known about if, and how, they might use these guidelines. Purpose. This study examined knowledge, awareness, and guideline-, client-, and environment-related factors influencing the use of the guidelines by OTs working with children (aged 3-4 years) with developmental disabilities. The secondary purpose was to explore relationships between these factors and OT education and experience. Method. The validated Clinician Guideline Determinants Questionnaire (n = 51 items) was administered via Qualtrics to a sample of Canadian pediatric OTs. Descriptive statistics were employed. Findings. Participants (n = 28 OTs) reported moderate to high agreement with the guidelines varying by movement type. Participants agreed they possessed the skills, knowledge, and external support to use the recommendations in practice but were less likely to agree with having training, implementation tools, and self-efficacy to implement the guidelines. Conclusion. Canada's 24-Hour Movement Guidelines hold potential for use by OTs, but capacity-building is required to support implementation. FAU - Taylor, Leah G AU - Taylor LG AUID- ORCID: 0000-0003-3731-492X FAU - Bourke, Matthew AU - Bourke M AUID- ORCID: 0000-0001-7088-4516 FAU - Alvarez, Liliana AU - Alvarez L AUID- ORCID: 0000-0001-9934-3414 FAU - Arbour-Nicitopoulos, Kelly P AU - Arbour-Nicitopoulos KP FAU - Burke, Shauna M AU - Burke SM FAU - Tucker, Patricia AU - Tucker P LA - eng PT - Journal Article DEP - 20250210 PL - United States TA - Can J Occup Ther JT - Canadian journal of occupational therapy. Revue canadienne d'ergotherapie JID - 0406021 SB - IM MH - Humans MH - Child, Preschool MH - Male MH - Female MH - *Occupational Therapy/standards MH - Canada MH - *Occupational Therapists/psychology MH - *Developmental Disabilities/rehabilitation MH - *Children with Disabilities/rehabilitation MH - Exercise MH - Surveys and Questionnaires MH - Health Knowledge, Attitudes, Practice MH - Practice Guidelines as Topic MH - *Guideline Adherence MH - Adult PMC - PMC12326028 OTO - NOTNLM OT - Ergotherapie OT - developmental disabilities OT - early years OT - incapacites developpementales OT - mouvement OT - movement OT - occupational therapy OT - petite enfance EDAT- 2025/02/11 06:22 MHDA- 2025/08/06 12:28 PMCR- 2025/08/06 CRDT- 2025/02/11 02:43 PHST- 2025/08/06 12:28 [medline] PHST- 2025/02/11 06:22 [pubmed] PHST- 2025/02/11 02:43 [entrez] PHST- 2025/08/06 00:00 [pmc-release] AID - 10.1177_00084174251318200 [pii] AID - 10.1177/00084174251318200 [doi] PST - ppublish SO - Can J Occup Ther. 2025 Sep;92(3):185-195. doi: 10.1177/00084174251318200. Epub 2025 Feb 10. PMID- 39930559 OWN - NLM STAT- MEDLINE DCOM- 20251118 LR - 20251215 IS - 1651-1905 (Electronic) IS - 1403-4948 (Linking) VI - 53 IP - 8 DP - 2025 Dec TI - Changes in physical activity among overweight and obese Norwegian children aged 6-12: A non-randomized cluster-controlled trial. PG - 872-880 LID - 10.1177/14034948251315350 [doi] AB - AIMS: To explore whether a family-based intervention with playful activities among overweight and obese Norwegian children promoted moderate to vigorous and light physical activity compared with a waiting list control group, and to examine whether gross motor competence, isometric body mass index and motivational factors, as reported by the children and their parents, could explain changes observed during a six-month observation. METHODS: A non-randomized cluster-controlled trial with 131 participants, 76 in the intervention group. Participants were aged 6-12 years, and 55 were boys. We performed linear regressions to compare the intervention and the control groups and adjusted linear models to examine predictors for outcomes with the groups merged into one cohort. RESULTS: We could not demonstrate any intervention effect from the family-based activities. Moderate to vigorous physical activity levels were satisfactory at the start and were maintained during the observation period. None of the predictors could explain outcome status at six months, nor residual change of moderate to vigorous physical activity during the observation. We revealed that parental educational attainment, parental autonomous motivation and the participants' experience of social support impacted light physical activity negatively after six months. Parental education also impacted the residual change of light physical activity negatively during the observation. CONCLUSIONS: The present family-based intervention to improve physical activity among overweight and obese children was ineffective. Baseline activity levels were already satisfactory. Paradoxically, factors such as parental socioeconomic status, autonomous motivation and self-reported support from parents and peers may be associated with diminished physical activity in such contexts. These unexpected findings need to be validated in further studies. FAU - Meland, Eivind AU - Meland E AUID- ORCID: 0000-0001-9161-1680 AD - Department of Global Public Health and Primary Care, University of Bergen, Norway. FAU - Abildsnes, Eirik AU - Abildsnes E AUID- ORCID: 0000-0002-5454-8560 AD - Department of Community Medicine and Global Health, University of Oslo, Kristiansand, Norway. FAU - Samdal, Gro B AU - Samdal GB AUID- ORCID: 0000-0001-6865-1254 AD - Faculty of Health Sciences, VID Specialized University, Bergen, Norway. FAU - Tonje Holte, Stea AU - Tonje Holte S AUID- ORCID: 0000-0002-3349-6706 AD - Department of Health and Nursing Science, University of Agder, Kristiansand, Norway. FAU - Haugen, Tommy AU - Haugen T AD - Department of Sport Science and Physical Education, University of Agder, Kristiansand, Norway. FAU - Berntsen, Sveinung AU - Berntsen S AD - Department of Sport Science and Physical Education, University of Agder, Kristiansand, Norway. FAU - Jahanlu, David AU - Jahanlu D AD - Faculty of Health Sciences, Oslo Metropolitan University, Norway. LA - eng PT - Controlled Clinical Trial PT - Journal Article DEP - 20250210 PL - Sweden TA - Scand J Public Health JT - Scandinavian journal of public health JID - 100883503 SB - IM MH - Humans MH - Norway MH - Male MH - Child MH - Female MH - *Exercise MH - *Pediatric Obesity/therapy MH - *Overweight/therapy MH - Motivation MH - *Health Promotion/methods OTO - NOTNLM OT - Activity physical OT - autonomous motivation OT - children OT - families OT - non-randomized trial OT - socioeconomic status COIS- Declaration of conflicting interestsThe authors have no conflicts of interest to declare. EDAT- 2025/02/11 06:21 MHDA- 2025/11/18 06:26 CRDT- 2025/02/11 00:03 PHST- 2025/11/18 06:26 [medline] PHST- 2025/02/11 06:21 [pubmed] PHST- 2025/02/11 00:03 [entrez] AID - 10.1177/14034948251315350 [doi] PST - ppublish SO - Scand J Public Health. 2025 Dec;53(8):872-880. doi: 10.1177/14034948251315350. Epub 2025 Feb 10. PMID- 39930520 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250212 IS - 2055-0928 (Electronic) IS - 2055-0928 (Linking) VI - 11 IP - 1 DP - 2025 Feb 10 TI - A central role of nutrition in cognitive function among primary school children: a cross-sectional analysis. PG - 35 LID - 10.1186/s40795-025-01016-2 [doi] LID - 35 AB - BACKGROUND: Childhood overweight and obesity have implications that extend beyond physical health. Despite evidence linking obesity to poorer cognition, the combined effects of weight status and dietary habits on cognitive function in children remain insufficiently studied. This study took a comprehensive approach investigating effects of weight status on cognition, incorporating socio-economic factors, parental anthropometrics, and detailed nutrition assessments in primary school children. METHODS: Anthropometric measurements, cognitive testing and short interviews were performed in schools from October 2021 until July 2022 in the Rhein-Neckar region, Germany. Cognitive testing included the distractibility and flexibility modules of the PSYTEST KiTap battery, alongside a self-designed short-term memory assessment. Parents were asked to provide information on physical activity, socioeconomic status (SES) and nutrition (3-day food diary and a questionnaire). Pearson's correlations were used for normally distributed continuous data, and Spearman's correlations for nonparametric data Pearson's or Spearman's correlation coefficients were calculated based on data distribution. RESULTS: A total of 256 children with a mean age of 8.0 years participated in the study. According to German growth reference tables, 16% were underweight, 75% normal weight, 5% overweight and 5% obese. Cognitive testing resulted in an average age- and sex adjusted performance. No significant correlations were found between any of the anthropometric variables collected and the cognitive domains studied. At the same time, cognition was associated with nutrition, physical activity and SES with strongest associations between reaction time in the flexibility task and fat consumption (R -0.35, p < 0.001), total kilocalories (R -0.30, p < 0.001) and protein (R -0.30, p < 0.001). CONCLUSIONS: The cognitive domains studied are not associated with anthropometric variables in primary school children. Nutrition appears to have strongest associations with cognition followed by other factors such as physical activity and SES. This study underlines the importance of nutrition for cognitive function and emphasizes the need to include nutrition in studies on cognitive performance and body weight status in schoolchildren. The study was registered at clinicaltrials.gov on September 21st 2021 under the registration number NCT05077059. CI - (c) 2025. The Author(s). FAU - Samigullin, Azat AU - Samigullin A AD - StarScience GmbH, Heidelberg, Germany. azat.samigullin@starscience.de. AD - Stoffwechselzentrum Rhein-Pfalz, Mannheim, Germany. azat.samigullin@starscience.de. FAU - Gahlert, Jana AU - Gahlert J AD - Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, Germany. FAU - Gross, Gabriel AU - Gross G AD - Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. FAU - Morcos, Michael AU - Morcos M AD - Stoffwechselzentrum Rhein-Pfalz, Mannheim, Germany. AD - Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. FAU - Schwertz, Rainer AU - Schwertz R AD - Gesundheitsamt Rhein-Neckar-Kreis, Heidelberg, Germany. FAU - Oste, Rickard AU - Oste R AD - Aventure AB, Lund, Sweden. FAU - Siegel, Erhard AU - Siegel E AD - St. Josefskrankenhaus, Heidelberg, Germany. AD - Adipositasnetzwerk Rhein-Neckar e. V, Heidelberg, Germany. FAU - Humpert, Per AU - Humpert P AD - Stoffwechselzentrum Rhein-Pfalz, Mannheim, Germany. AD - Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, Germany. LA - eng SI - ClinicalTrials.gov/NCT05077059 PT - Journal Article DEP - 20250210 PL - England TA - BMC Nutr JT - BMC nutrition JID - 101672434 PMC - PMC11809016 OTO - NOTNLM OT - Child development OT - Cognitive flexibility OT - Community child health OT - Distractibility OT - Memory OT - Nutrition OT - Obesity OT - Pediatrics OT - Psychometrics OT - Schools COIS- Declarations. Ethics approval and consent to participate: The study was performed in accordance with the Declaration of Helsinki and approved by the local ethics committee (Ethikkommission der Landesarztekammer Baden-Wurttemberg, Aktenzeichen: F-2021-037) and the school authority (Regierungsprasidium Karlsruhe, Aktenzeichen: 71f1-6499.25). Individual informed consent from legal guardians/parents was necessary for participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/02/11 00:19 MHDA- 2025/02/11 00:20 PMCR- 2025/02/10 CRDT- 2025/02/10 23:51 PHST- 2023/12/13 00:00 [received] PHST- 2025/01/29 00:00 [accepted] PHST- 2025/02/11 00:20 [medline] PHST- 2025/02/11 00:19 [pubmed] PHST- 2025/02/10 23:51 [entrez] PHST- 2025/02/10 00:00 [pmc-release] AID - 10.1186/s40795-025-01016-2 [pii] AID - 1016 [pii] AID - 10.1186/s40795-025-01016-2 [doi] PST - epublish SO - BMC Nutr. 2025 Feb 10;11(1):35. doi: 10.1186/s40795-025-01016-2. PMID- 39930422 OWN - NLM STAT- MEDLINE DCOM- 20250506 LR - 20250506 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Feb 10 TI - Predicting metabolic syndrome by lipid accumulation product, visceral adiposity index and body roundness index in Brazilian rural workers. PG - 544 LID - 10.1186/s12889-025-21624-8 [doi] LID - 544 AB - BACKGROUND: Anthropometric indicators, such as the Lipid Accumulation Product (LAP), the Visceral Adiposity Index (VAI), and the Body Roundness Index (BRI), could be valuable tools for identifying metabolic syndrome (MS) in rural populations because of their simplicity, low cost, and ability to identify central obesity and related metabolic risks where access to healthcare is limited. This study aimed to evaluate the predictive capacity of three anthropometric indices for identifying MS in a representative sample of rural workers in Espirito Santo, Brazil. METHODS: A cross-sectional analysis was conducted, and the diagnostic performance of these indices was assessed via ROC curves under the NCEP and IDF criteria for MS. The study involved 806 participants, aged 18-59 years, and the data collection included anthropometric measurements, biochemical tests, and blood pressure assessments. RESULTS: The results showed that LAP had the highest discriminatory capacity for MS under both diagnostic criteria, with AUCs of 0.803 (NCEP) and 0.885 (IDF), followed by BRI and VAI. The cutoff points identified for LAP were 33.84 (NCEP) and 26.80 (IDF), with high sensitivity and specificity. The BRI also demonstrated strong predictive power with AUC values above 0.7, whereas the VAI had the lowest AUC among the indices but remained a useful predictor. The correlations between the indices and MS components highlighted significant relationships, especially between LAP and triglycerides (r = 0.830). CONCLUSIONS: This is the first study to determine cutoff points for these indices in a rural Brazilian population, suggesting that LAP and BRI are reliable tools for MS screening. The low cost of these methods could aid in improving healthcare accessibility and prevention strategies in rural areas with limited resources. Future research is recommended to validate these findings in other populations. CI - (c) 2025. The Author(s). FAU - Ferreira, Julia Rabelo Santos AU - Ferreira JRS AUID- ORCID: 0000-0002-5022-0111 AD - Graduate Program in Public Health, Federal University of Espirito Santo, Marechal Campos Avenue, 1468, Maruipe, Vitoria, ES, Brazil. juliarabelos@gmail.com. FAU - Libardi, Manoela Cassa AU - Libardi MC AUID- ORCID: 0000-0002-6249-1891 AD - Graduate Program in Public Health, Federal University of Espirito Santo, Marechal Campos Avenue, 1468, Maruipe, Vitoria, ES, Brazil. FAU - do Prado, Camila Bruneli AU - do Prado CB AUID- ORCID: 0000-0002-1762-6064 AD - Graduate Program in Public Health, Federal University of Espirito Santo, Marechal Campos Avenue, 1468, Maruipe, Vitoria, ES, Brazil. FAU - Zandonade, Eliana AU - Zandonade E AUID- ORCID: 0000-0001-5160-3280 AD - Graduate Program in Public Health, Federal University of Espirito Santo, Marechal Campos Avenue, 1468, Maruipe, Vitoria, ES, Brazil. FAU - Bezerra, Olivia Maria de Paula Alves AU - Bezerra OMPA AUID- ORCID: 0000-0002-5596-657X AD - Department of Clinical and Social Nutrition, School of Nutrition, Federal University of Ouro, Preto, Ouro Preto, MG, Brazil. FAU - Salaroli, Luciane Bresciani AU - Salaroli LB AUID- ORCID: 0000-0002-1881-0306 AD - Graduate Program in Public Health, Federal University of Espirito Santo, Marechal Campos Avenue, 1468, Maruipe, Vitoria, ES, Brazil. AD - Graduate Program in Nutrition and Health, Federal University of Espirito Santo, Vitoria, ES, Brazil. LA - eng GR - Fapes/CNPq/Decit-SCTIE-MS/ SESA no 05/2015- PPSUS/Research Program of the Unified Health System (PPSUS)/ PT - Journal Article DEP - 20250210 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Brazil/epidemiology MH - Adult MH - Male MH - Female MH - Cross-Sectional Studies MH - *Metabolic Syndrome/diagnosis MH - Middle Aged MH - Adolescent MH - Young Adult MH - *Rural Population/statistics & numerical data MH - *Lipid Accumulation Product MH - *Intra-Abdominal Fat MH - *Adiposity MH - Anthropometry/methods MH - Predictive Value of Tests PMC - PMC11812240 OTO - NOTNLM OT - Lipid accumulation product OT - Metabolic syndrome OT - Rural population COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Research Ethics Committee of the Health Sciences Center of the Federal University of Espirito Santo, Opinion no. 2091172 (CAAE 52839116.3.0000.5060). All participants signed the Informed Consent Form. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/02/11 00:19 MHDA- 2025/02/11 06:22 PMCR- 2025/02/10 CRDT- 2025/02/10 23:46 PHST- 2024/10/18 00:00 [received] PHST- 2025/01/24 00:00 [accepted] PHST- 2025/02/11 06:22 [medline] PHST- 2025/02/11 00:19 [pubmed] PHST- 2025/02/10 23:46 [entrez] PHST- 2025/02/10 00:00 [pmc-release] AID - 10.1186/s12889-025-21624-8 [pii] AID - 21624 [pii] AID - 10.1186/s12889-025-21624-8 [doi] PST - epublish SO - BMC Public Health. 2025 Feb 10;25(1):544. doi: 10.1186/s12889-025-21624-8. PMID- 39928623 OWN - NLM STAT- MEDLINE DCOM- 20250210 LR - 20261014 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 2 DP - 2025 TI - Adolescent weight management counseling: The effectiveness of an online training program for primary healthcare professionals in Indonesia. PG - e0315770 LID - 10.1371/journal.pone.0315770 [doi] LID - e0315770 AB - BACKGROUND: Overweight and obesity are growing public health concerns globally for which innovative prevention and care delivery efforts are required. We recently developed a web-based training program to improve the quality of health professionals' weight management counseling of adolescents in Indonesia. Having previously confirmed its acceptability, this study aimed to measure the effectiveness of the program through a randomized controlled trial. METHODS: We recruited 64 primary healthcare professionals from 17 provinces across Indonesia who were randomized to participate in a 4-week online training program (intervention group [IG, n = 32] or a waitlist control group [CG, n = 32]). Using active learning approaches, the training program focused on adolescent development, psychosocial assessment, motivational interviewing (MI), and parent engagement. Participants in each arm were asked to record two counseling sessions with adolescents. These were objectively rated by trained psychologists using a validated tool, and also by qualitative assessment of counseling quality. In both groups, the first recorded counseling session occurred before the training. The second recording took place after the training for IG participants, but not for CG participants. RESULTS: IG participants demonstrated significant improvements in their knowledge and counseling skills (p<0.001, t-test). This included improvements in introductory remarks, quality of psychosocial assessment, and MI skills. There was no change in the extent of parental involvement. The MI training successfully oriented the counseling sessions towards a more collaborative and participatory conversation for supporting behavioral change. CONCLUSION: This novel online training program improved the knowledge and counseling skills of Indonesian primary healthcare professionals. Greater emphasis on engaging parents and more guidance on conducting telehealth counseling may improve parental involvement in future iterations. CI - Copyright: (c) 2025 Agung et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Agung, Fransisca H AU - Agung FH AUID- ORCID: 0000-0003-3516-6089 AD - Faculty of Medicine, Universitas Pelita Harapan, Kelapa Dua, Tangerang, Banten, Indonesia. FAU - Sekartini, Rini AU - Sekartini R AD - Department of Child Health, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia. FAU - Sudarsono, Nani AU - Sudarsono N AD - Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia. FAU - Hendarto, Aryono AU - Hendarto A AD - Department of Child Health, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia. FAU - Werdhani, Retno Asti AU - Werdhani RA AD - Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia. FAU - Dhamayanti, Meita AU - Dhamayanti M AD - Department of Child Health, Faculty of Medicine Universitas Padjajaran, Bandung, West Java, Indonesia. FAU - Pudjiati, Retno AU - Pudjiati R AUID- ORCID: 0000-0001-5231-7139 AD - Faculty of Psychology Universitas Indonesia, Kampus UI, Depok, West Java, Indonesia. FAU - Hanum, Lathifah AU - Hanum L AUID- ORCID: 0000-0003-1771-335X AD - Faculty of Psychology Universitas Indonesia, Kampus UI, Depok, West Java, Indonesia. FAU - Naufal, Affan AU - Naufal A AD - Balaraja District Hospital, Tangerang, Banten, Indonesia. FAU - Sawyer, Susan M AU - Sawyer SM AD - Centre for Adolescent Health, Royal Children's Hospital, Murdoch Children's Research Institute, and Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia. LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20250210 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Indonesia MH - Female MH - Male MH - Adolescent MH - *Counseling/education MH - *Health Personnel/education MH - Primary Health Care MH - Adult MH - Motivational Interviewing MH - Internet MH - Education, Distance PMC - PMC11809861 COIS- The authors have declared that no competing interests exist EDAT- 2025/02/10 18:16 MHDA- 2025/02/10 18:17 PMCR- 2025/02/10 CRDT- 2025/02/10 13:34 PHST- 2024/02/05 00:00 [received] PHST- 2024/11/30 00:00 [accepted] PHST- 2025/02/10 18:17 [medline] PHST- 2025/02/10 18:16 [pubmed] PHST- 2025/02/10 13:34 [entrez] PHST- 2025/02/10 00:00 [pmc-release] AID - PONE-D-23-35751 [pii] AID - 10.1371/journal.pone.0315770 [doi] PST - epublish SO - PLoS One. 2025 Feb 10;20(2):e0315770. doi: 10.1371/journal.pone.0315770. eCollection 2025. PMID- 39927403 OWN - NLM STAT- MEDLINE DCOM- 20250506 LR - 20260127 IS - 1365-277X (Electronic) IS - 0952-3871 (Print) IS - 0952-3871 (Linking) VI - 38 IP - 1 DP - 2025 Feb TI - Dietary Energy and Nutrient Intake Among Pregnant Women in Sri Lanka: Findings From the Sri Lanka Mother and Newborn Growth Cohort Study. PG - e70020 LID - 10.1111/jhn.70020 [doi] LID - e70020 AB - BACKGROUND: Maternal nutrition during pregnancy is crucial to ensure positive outcomes for both the mother and newborn. Despite its importance, maternal nutritional status remains poor, particularly in low- and middle-income countries, where social, cultural and economic factors play a pivotal role. This study assessed the adequacy of energy and dietary nutrient intake among Sri Lankan pregnant women compared to their dietary reference intakes. METHODS: This study was part of the Sri Lanka Mother and Newborn Growth study, a nationwide prospective cohort of 2000 pregnant women. We prospectively investigated maternal dietary intake using a validated food frequency questionnaire during the first, second and third trimesters. RESULTS: We observed an imbalanced macronutrient distribution, with carbohydrates contributing over 67% of total median energy intake, while protein and fat contributed approximately 11% and 17%, respectively. Ethnic and socio-economic disparities in energy and macronutrient intake were notable. The Sinhalese ethnic group showed the highest median percentage of energy consumption derived from carbohydrates at 68.0% (IQR: 64.6%‒71.1%), significantly exceeding the intake of Tamil and Moor groups. Estate residents reported the lowest proportion of energy from protein (10.6%, IQR: 10.1%‒11.3%), which was significantly lower than the intakes of urban and rural residents. Additionally, women in the lowest income group had a lower total energy intake (1871 kcal/day, IQR: 1464-2392) than those in higher income groups, highlighting socio-economic influences on maternal nutrition. Micronutrient deficiencies were pervasive, particularly for vitamin B2 (88.6%-91.0%), folate (99.3%-99.8%), vitamin B12 (97.8%-99.5%), calcium (80.8%-91.4%) and iron (91.1%-96.5%). Sodium intake exceeded recommended levels for over 75% of women across all trimesters. CONCLUSION: Imbalances in macronutrient intake and widespread micronutrient deficiencies among Sri Lankan pregnant women underscore the urgent need for interventions targeting maternal nutrition. Addressing socio-economic disparities is critical to improving maternal and neonatal health outcomes. CI - (c) 2025 The Author(s). Journal of Human Nutrition and Dietetics published by John Wiley & Sons Ltd on behalf of British Dietetic Association. FAU - Pathirathna, Malshani Lakshika AU - Pathirathna ML AUID- ORCID: 0000-0002-6898-5315 AD - Department of Midwifery and Women's Health, Graduate School of Medicine, Division of Health Sciences and Nursing, The University of Tokyo, Tokyo, Japan. AD - Department of Nursing, Faculty of Allied Health Sciences, University of Peradeniya, Peradeniya, Sri Lanka. FAU - Haruna, Megumi AU - Haruna M AD - Department of Midwifery and Women's Health, Graduate School of Medicine, Division of Health Sciences and Nursing, The University of Tokyo, Tokyo, Japan. AD - Graduate School of Medicine, Global Nursing Research Center, The University of Tokyo, Tokyo, Japan. FAU - Sasaki, Satoshi AU - Sasaki S AD - Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo, Japan. FAU - Yonezawa, Kaori AU - Yonezawa K AUID- ORCID: 0000-0002-8160-3721 AD - Department of Midwifery and Women's Health, Graduate School of Medicine, Division of Health Sciences and Nursing, The University of Tokyo, Tokyo, Japan. AD - Graduate School of Medicine, Global Nursing Research Center, The University of Tokyo, Tokyo, Japan. FAU - Usui, Yuriko AU - Usui Y AD - Department of Midwifery and Women's Health, Graduate School of Medicine, Division of Health Sciences and Nursing, The University of Tokyo, Tokyo, Japan. AD - Graduate School of Medicine, Global Nursing Research Center, The University of Tokyo, Tokyo, Japan. FAU - Hagiwara, Yasuhiro AU - Hagiwara Y AD - Department of Biostatistics, School of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. LA - eng GR - This study was supported by Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science, Ministry of Education, Culture, Sports, Science, and Technology (Grant numbers 22F22407, 22KF0122, and 24KF0014)./ PT - Journal Article PL - England TA - J Hum Nutr Diet JT - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JID - 8904840 RN - 0 (Nutrients) RN - 0 (Dietary Proteins) RN - 0 (Micronutrients) SB - IM MH - Humans MH - Female MH - Sri Lanka MH - Pregnancy MH - *Energy Intake MH - Adult MH - Prospective Studies MH - *Maternal Nutritional Physiological Phenomena MH - *Diet/statistics & numerical data MH - *Nutrients/administration & dosage MH - Infant, Newborn MH - Socioeconomic Factors MH - Nutritional Status MH - Cohort Studies MH - Young Adult MH - Dietary Proteins/administration & dosage MH - Micronutrients/administration & dosage PMC - PMC11808640 OTO - NOTNLM OT - dietary reference intake OT - energy intake OT - maternal health OT - micronutrients OT - nutrients OT - nutrition status OT - pregnancy nutrition COIS- The authors declare no conflicts of interest. EDAT- 2025/02/10 06:21 MHDA- 2025/02/10 12:23 PMCR- 2025/02/10 CRDT- 2025/02/10 05:49 PHST- 2025/01/16 00:00 [revised] PHST- 2024/10/18 00:00 [received] PHST- 2025/01/21 00:00 [accepted] PHST- 2025/02/10 12:23 [medline] PHST- 2025/02/10 06:21 [pubmed] PHST- 2025/02/10 05:49 [entrez] PHST- 2025/02/10 00:00 [pmc-release] AID - JHN70020 [pii] AID - 10.1111/jhn.70020 [doi] PST - ppublish SO - J Hum Nutr Diet. 2025 Feb;38(1):e70020. doi: 10.1111/jhn.70020. PMID- 39926292 OWN - NLM STAT- MEDLINE DCOM- 20250507 LR - 20260701 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 12 DP - 2024 TI - The big five personality traits and eating habits among female students at Zayed University. PG - 1490634 LID - 10.3389/fpubh.2024.1490634 [doi] LID - 1490634 AB - BACKGROUND: Adhering to healthy dietary habits is crucial for disease prevention and improving overall quality of life. Understanding how personality traits influence eating behaviors is essential for developing effective interventions aimed at promoting healthier eating habits. Personality traits are consistent behavioral patterns that individuals typically exhibit, and the Five-Factor Model (also known as the Big Five) is widely recognized as an effective framework for predicting personality traits. METHODS: This study analyzed the relationship between personality traits and eating behaviors among 425 female students using a cross-sectional design. Sociodemographic data and personality traits were assessed using an online questionnaire, while eating behaviors were evaluated with the validated Three-Factor Eating Questionnaire (TFEQ). Key aspects of eating behavior studied included cognitive restraint, disinhibition, and emotional eating. The findings provide insights into how personality characteristics may influence eating habits, offering potential implications for interventions targeting healthier eating behaviors. RESULTS: The majority of participants scored highest on the personality trait of openness to experience. The study found that certain personality traits, particularly neuroticism and agreeableness, were linked to dietary habits. Specifically, personality traits were associated with emotional eating (p < 0.003), but not with cognitive restraint (p = 0.25) or disinhibition (p = 0.308). Participants with higher levels of agreeableness demonstrated significantly higher cognitive restraint (p = 0.041). CONCLUSION: Personality traits can influence eating habits, particularly emotional eating. However, further research is needed to identify individuals at risk for diet-related diseases and to determine the most effective intervention strategies. This study is the first of its kind conducted in the United Arab Emirates, contributing valuable insights into the relationship between personality traits and eating behaviors. CI - Copyright (c) 2025 AlBlooshi, AlSabbah, Thani, Hijazi, Al Dhaheri, Zeb and Cheikh Ismail. FAU - AlBlooshi, Sharifa AU - AlBlooshi S AD - Department of Health Sciences, College of Natural and Health Sciences, Zayed University, Dubai, United Arab Emirates. FAU - AlSabbah, Kawther AU - AlSabbah K AD - Department of Health Sciences, College of Natural and Health Sciences, Zayed University, Dubai, United Arab Emirates. FAU - Thani, Shatha AU - Thani S AD - Department of Health Sciences, College of Natural and Health Sciences, Zayed University, Dubai, United Arab Emirates. FAU - Hijazi, Rafiq AU - Hijazi R AD - Department of Mathematics and Statistics, College of Natural and Health Sciences, Zayed University, Abu Dhabi, United Arab Emirates. FAU - Al Dhaheri, Ayesha S AU - Al Dhaheri AS AD - Department of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. FAU - Zeb, Falak AU - Zeb F AD - Nutrition and Food Research Group, Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. FAU - Cheikh Ismail, Leila AU - Cheikh Ismail L AD - Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. AD - Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, United Kingdom. LA - eng PT - Journal Article DEP - 20250115 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Female MH - *Feeding Behavior/psychology MH - *Students/psychology/statistics & numerical data MH - Cross-Sectional Studies MH - *Personality MH - Universities MH - Surveys and Questionnaires MH - Young Adult MH - Adult MH - Adolescent MH - United Arab Emirates PMC - PMC11803861 OTO - NOTNLM OT - UAE students OT - agreeableness OT - conscientiousness OT - eating habits OT - extraversion OT - neuroticism OT - openness OT - personality traits COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/02/10 06:21 MHDA- 2025/02/10 06:22 PMCR- 2025/01/15 CRDT- 2025/02/10 05:37 PHST- 2024/09/03 00:00 [received] PHST- 2024/12/24 00:00 [accepted] PHST- 2025/02/10 06:22 [medline] PHST- 2025/02/10 06:21 [pubmed] PHST- 2025/02/10 05:37 [entrez] PHST- 2025/01/15 00:00 [pmc-release] AID - 10.3389/fpubh.2024.1490634 [doi] PST - epublish SO - Front Public Health. 2025 Jan 15;12:1490634. doi: 10.3389/fpubh.2024.1490634. eCollection 2024. PMID- 39925173 OWN - NLM STAT- MEDLINE DCOM- 20250506 LR - 20260421 IS - 1526-4610 (Electronic) IS - 0017-8748 (Linking) VI - 65 IP - 4 DP - 2025 Apr TI - Association between obstructive sleep apnea and migraine: A United States population-based cohort study. PG - 608-618 LID - 10.1111/head.14904 [doi] AB - OBJECTIVE: To determine the association between obstructive sleep apnea (OSA) and the incidence of migraine using a large population-based dataset, as well as to identify the at-risk target groups. BACKGROUND: Epidemiological and biochemical studies have provided evidence for the close connection between sleep disorders and migraine. Understanding the connections between OSA and migraine, as well as their shared risk factors, may provide new perspectives on the pathophysiology of both OSA and migraine and novel approaches to managing and treating these conditions. METHODS: This retrospective cohort study used data from the TriNetX network from 2010 to 2021. We compared 196,864 adult participants with OSA to a group of 196,864 participants who had never been diagnosed with OSA (1:1 propensity score-matching for age, sex, race, comorbidities, and body mass index [BMI] categories) in relation to the risk of incident migraine. We performed subgroup analyses based on age (18-39, 40-59, >/=60 years), sex (female, male), race (White, Black or African American, Asian), BMI categories (<18.5, 18.5-24.9, 25-29.9, >/=30 kg/m(2)), and the presence of hypoxemia (yes, no). Sensitivity analyses were performed to validate our findings. RESULTS: During the follow-up period, 12,613 (6.4%) and 6356 participants (3.2%) developed migraine in the OSA and non-OSA cohorts, respectively. Patients with OSA were found to have a 1.85-fold risk (hazard ratio [HR] 1.85; 95% confidence interval [CI] 1.79-1.90) of incident migraine when compared to those without OSA, after accounting for age, sex, race, and baseline comorbidities. The results were consistent in sensitivity analyses (test-negative design: HR 1.39, 95% CI 1.28-1.49) and also cross-validated in a different dataset from TriNetX (Global Collaborative Research Network: HR 1.88, 95% CI 1.82-1.93). The results of subgroup analysis by sex, age, race, BMI categories, and the presence of hypoxemia were generally consistent. CONCLUSION: We found OSA to be associated with an elevated risk of developing migraine using a large United States nationwide database, and the association was generalizable across sex, age, race, and BMI categories. Our results suggest that awareness of migraine should be increased among patients with OSA. The findings also encourage further research to clarify the role of obesity and overweight in the relationship between OSA and migraine, as well as the potential benefits of body weight control for those with these two comorbid conditions. CI - (c) 2025 American Headache Society. FAU - Chen, Thomas Yen-Ting AU - Chen TY AD - Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. FAU - Hsieh, Tina Yi-Jin AU - Hsieh TY AD - Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA. AD - Department of Obstetrics & Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. FAU - Wang, Yu-Hsun AU - Wang YH AD - Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan. FAU - Chang, Renin AU - Chang R AUID- ORCID: 0000-0003-1016-2233 AD - Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan. AD - Department of Recreation and Sports Management, Tajen University, Pingtung, Taiwan. AD - School of Medicine, Chung Shan Medical University, Taichung, Taiwan. AD - Department of Emergency Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan. FAU - Hung, Yao-Min AU - Hung YM AD - Division of Nephrology, Department of Internal Medicine, Taitung Hospital, Ministry of Health and Welfare, Taitung, Taiwan. AD - Master Program in Biomedicine, College of Science and Engineering, National Taitung University, Taitung, Taiwan. AD - College of Health and Nursing, Meiho University, Pingtung, Taiwan. FAU - Wei, James Cheng-Chung AU - Wei JC AD - Sanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China. AD - Department of Allergy, Immunology & Rheumatology, Chung Shan Medical University Hospital, Taichung, Taiwan. AD - Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan. AD - Institute of Medicine/Department of Nursing, Chung Shan Medical University, Taichung, Taiwan. LA - eng GR - CSH-2022-A-023/Chung Shan Medical University Hospital/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250210 PL - United States TA - Headache JT - Headache JID - 2985091R SB - IM MH - Humans MH - *Sleep Apnea, Obstructive/epidemiology MH - *Migraine Disorders/epidemiology MH - Male MH - Female MH - Adult MH - Middle Aged MH - United States/epidemiology MH - Retrospective Studies MH - Young Adult MH - Adolescent MH - Incidence MH - Comorbidity MH - Cohort Studies MH - Risk Factors OTO - NOTNLM OT - TriNetX OT - cohort OT - epidemiology OT - migraine OT - obstructive sleep apnea EDAT- 2025/02/10 06:21 MHDA- 2025/03/28 12:31 CRDT- 2025/02/10 04:03 PHST- 2024/10/18 00:00 [revised] PHST- 2024/05/01 00:00 [received] PHST- 2024/10/23 00:00 [accepted] PHST- 2025/03/28 12:31 [medline] PHST- 2025/02/10 06:21 [pubmed] PHST- 2025/02/10 04:03 [entrez] AID - 10.1111/head.14904 [doi] PST - ppublish SO - Headache. 2025 Apr;65(4):608-618. doi: 10.1111/head.14904. Epub 2025 Feb 10. PMID- 39924960 OWN - NLM STAT- MEDLINE DCOM- 20250515 LR - 20250515 IS - 1943-572X (Electronic) IS - 0003-4894 (Linking) VI - 134 IP - 6 DP - 2025 Jun TI - Reliability and Validity of a Pediatric Drug-Induced Sleep Endoscopy Grading System (PedDISE-8). PG - 420-426 LID - 10.1177/00034894251318158 [doi] AB - OBJECTIVES: Drug-induced sleep endoscopy (DISE) is increasingly being used in children with obstructive sleep apnea (OSA) to identify specific sites of upper airway obstruction and plan surgical interventions. This study aims to test the reliability and validity of a new grading system for pediatric DISE procedures (PedDISE-8). METHODS: We conducted a retrospective chart review of children 0 to 18 years old with OSA who underwent DISE. Four independent raters reviewed and graded each video recording twice using the PedDISE-8. Eight upper airway sites were evaluated: inferior turbinates, adenoid, velum, tonsils/lateral pharyngeal walls, lingual tonsils, tongue base, epiglottis, and supra-arytenoid tissue. Intraclass correlation coefficients were calculated to determine inter-rater and intra-rater rating reliability for each site. External validity was assessed by analyzing the correlation between the number of sites with severe obstruction and polysomnographic data. RESULTS: DISE recordings were reviewed for 86 pediatric patients, 59.5% of whom were male and 26.7% were obese. The median age was 3.5 (IQR 2.4-5.3) years, and the median obstructive apnea-hypopnea index (oAHI) was 5.5 (IQR 3.1-10.4). Moderate to good inter-rater and intra-rater reliability were found for all eight sites (intraclass correlation coefficient 0.67 to 0.88 and 0.71 to 0.87, respectively). The number of sites with severe obstruction correlated positively with the oAHI (tau = 0.119, P = .004). CONCLUSIONS: The PedDISE-8 grading system demonstrated good inter-rater and intra-rater reliability and external validity. It can be used in children undergoing DISE for OSA. FAU - Jaffal, Hussein AU - Jaffal H AUID- ORCID: 0000-0003-4338-7658 AD - Department of Otolaryngology-Head and Neck Surgery, West Virginia University, Morgantown, WV, USA. FAU - Coutras, Steven W AU - Coutras SW AD - Department of Otolaryngology-Head and Neck Surgery, West Virginia University, Morgantown, WV, USA. FAU - Dewey, John AU - Dewey J AD - Department of Otolaryngology-Head and Neck Surgery, West Virginia University, Morgantown, WV, USA. FAU - McArdle, Erica AU - McArdle E AD - Department of Otolaryngology-Head and Neck Surgery, West Virginia University, Morgantown, WV, USA. FAU - Cui, Ruifeng AU - Cui R AD - Department of Otolaryngology-Head and Neck Surgery, West Virginia University, Morgantown, WV, USA. LA - eng PT - Journal Article PT - Validation Study DEP - 20250209 PL - United States TA - Ann Otol Rhinol Laryngol JT - The Annals of otology, rhinology, and laryngology JID - 0407300 RN - 0 (Hypnotics and Sedatives) SB - IM MH - Humans MH - *Sleep Apnea, Obstructive/diagnosis/surgery/physiopathology MH - Male MH - Child MH - Retrospective Studies MH - Child, Preschool MH - Female MH - Reproducibility of Results MH - *Endoscopy/methods MH - Adolescent MH - Infant MH - Polysomnography MH - Video Recording MH - Sleep MH - Hypnotics and Sedatives/administration & dosage MH - Severity of Illness Index OTO - NOTNLM OT - DISE OT - children OT - drug-induced sleep endoscopy OT - obstructive sleep apnea OT - pediatric COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/02/10 06:21 MHDA- 2025/05/15 12:36 CRDT- 2025/02/10 02:13 PHST- 2025/05/15 12:36 [medline] PHST- 2025/02/10 06:21 [pubmed] PHST- 2025/02/10 02:13 [entrez] AID - 10.1177/00034894251318158 [doi] PST - ppublish SO - Ann Otol Rhinol Laryngol. 2025 Jun;134(6):420-426. doi: 10.1177/00034894251318158. Epub 2025 Feb 9. PMID- 39924577 OWN - NLM STAT- MEDLINE DCOM- 20250729 LR - 20261010 IS - 1573-3610 (Electronic) IS - 0094-5145 (Linking) VI - 50 IP - 4 DP - 2025 Aug TI - Carbonated Beverage Consumption Among Saudi Adults Before and After Implementation of Soft Drink Tax. PG - 577-584 LID - 10.1007/s10900-025-01447-9 [doi] AB - The prevalence of obesity in Saudi Arabia has increased dramatically, with approximately 35% of the population estimated to be obese. This study assessed the patterns of carbonated beverage consumption and the factors and attitudes influencing consumption before and after implementing new soft drink taxes among Saudi adults. A secondary analysis was conducted on two cross-sectional studies involving Saudi adults aged over 18 years. The studies were conducted in July-September 2016 (Pre taxation, n = 964) and October 2022-March 2023 (post taxation, n = 1931). Data were collected using a validated questionnaire that included sociodemographic information, consumption patterns, influencing factors, and attitudes. A chi-square test compared frequency changes between the two periods, while a linear regression model assessed the impact of taxation on consumption frequency and quantity, along with associated factors and attitudes. Daily carbonated beverage consumption increased from 6% pre-taxation to 8% post-taxation. Significant changes were observed in factors and attitudes toward consumption (P < 0.05). The perceived influence of advertising decreased significantly (-0.320, P < 0.0001), while consumption during meals at home (0.430, P < 0.0001) and while watching TV or using electronic devices (0.231, P < 0.0001) increased post-taxation. The findings indicate that despite taxation, carbonated beverage consumption did not decrease among Saudi adults. These results underscore the need for comprehensive health promotion and intervention programs to address the high consumption of sugar-sweetened beverages and mitigate their health impacts. CI - (c) 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Alzaben, Abeer S AU - Alzaben AS AUID- ORCID: 0000-0001-9813-1524 AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia. FAU - Aljahdali, Abeer A AU - Aljahdali AA AD - Department of Clinical Nutrition, Faculty of Applied Medical Sciences, King Abdulaziz University, P.O. Box 80215, Jeddah, 21589, Saudi Arabia. AD - Department of Nutritional Sciences, University of Michigan, Ann Arbor, MI, 48109, USA. FAU - Almoayad, Fatmah AU - Almoayad F AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia. FAU - Benajiba, Nada AU - Benajiba N AD - Unite Mixte de Recherche en Nutrition et Alimentation URAC 39, Universite Ibn Tofail-CNESTEN), RDC- Nutrition, Kenitra, Morocco. FAU - Alabdulkader, Shahd AU - Alabdulkader S AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia. FAU - Bawazeer, Nahla Mohammed AU - Bawazeer NM AUID- ORCID: 0000-0001-5087-7802 AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia. NMBawazeer@pnu.edu.sa. LA - eng GR - PNURSP2025R207/Deanship of Scientific Research, Princess Nourah Bint Abdulrahman University/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250209 PL - Netherlands TA - J Community Health JT - Journal of community health JID - 7600747 SB - IM EIN - J Community Health. 2025 Dec;50(6):1179. doi: 10.1007/s10900-025-01509-y. PMID: 41131414 MH - Humans MH - *Carbonated Beverages/economics/statistics & numerical data MH - Saudi Arabia/epidemiology MH - *Taxes/statistics & numerical data MH - Adult MH - Male MH - Female MH - Cross-Sectional Studies MH - Middle Aged MH - Young Adult MH - Adolescent MH - Surveys and Questionnaires OTO - NOTNLM OT - Attitude OT - Carbonated beverages OT - Consumption OT - Saudi OT - Taxation COIS- Declarations. Competing Interests: The authors declare no competing interests. EDAT- 2025/02/10 00:19 MHDA- 2025/07/29 18:31 CRDT- 2025/02/09 23:18 PHST- 2025/01/21 00:00 [accepted] PHST- 2025/07/29 18:31 [medline] PHST- 2025/02/10 00:19 [pubmed] PHST- 2025/02/09 23:18 [entrez] AID - 10.1007/s10900-025-01447-9 [pii] AID - 10.1007/s10900-025-01447-9 [doi] PST - ppublish SO - J Community Health. 2025 Aug;50(4):577-584. doi: 10.1007/s10900-025-01447-9. Epub 2025 Feb 9. PMID- 39924573 OWN - NLM STAT- MEDLINE DCOM- 20250209 LR - 20260623 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Feb 9 TI - Factor structure and measurement invariance of exercise self-efficacy scale among secondary school students in China. PG - 4844 LID - 10.1038/s41598-025-89287-4 [doi] LID - 4844 AB - Exercise Self-Efficacy Scale (ESES) is widely used to assess individuals' exercise self-efficacy through self-reporting. It includes one factor and 18 items that gauge one's confidence in exercising under various conditions, such as when tired, stressed, or in unfavourable weather. Evidence indicates that differences in the original factor structure and psychometric properties were observed across different populations, including school-age students, university students, and adults. This study examined the factor structure, reliability, convergent validity, and measurement invariance of the Chinese version of the ESES among secondary school students. Data from 856 students (age: M = 13.80, SD = 0.94) were analysed using exploratory and confirmatory factor analyses to identify the best-fitting factor structure. The reliability and convergent validity were tested using the collected data. Configural, metric, and scalar invariances, as well as the likelihood ratio test, were tested for measurement invariance. A 14-item, two-factor structure of the ESES, consistently demonstrated the best fit among secondary school students. The two-factor structure showed strong internal consistency reliability (McDonald's Omega of 0.921 and 0.843) and satisfactory convergent validity (average variance extracted values of 0.582 and 0.478, composite reliability values of 0.917 and 0.845). Multi-group confirmatory factor analysis (likelihood ratio test, p > 0.01) revealed scalar measurement invariance across sex, ethnic backgrounds, grades, and school locations. These findings suggest that the 14-item, two-factor Chinese version of the ESES is suitable for use with secondary-school students. Future studies could confirm these findings by examining the 14-item, two-factor ESES in diverse samples, considering ethnicity, socioeconomic status, and age range. CI - (c) 2025. The Author(s). FAU - Qin, Ling AU - Qin L AD - Faculty of Physical Education and Health Science, Chongqing Normal University, Chongqing, China. AD - Faculty of Sports and Exercise Science, Universiti Malaya, Kuala Lumpur, Malaysia. FAU - Ho, Walter King Yan AU - Ho WKY AD - Tokyo Gakugei University, Tokyo, Japan. FAU - Khoo, Selina AU - Khoo S AD - Faculty of Sports and Exercise Science, Universiti Malaya, Kuala Lumpur, Malaysia. selina@um.edu.my. LA - eng GR - KJQN202200502/the Natural Science Fund of the Chongqing Municipal Education Commission in China/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250209 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - *Self Efficacy MH - China MH - *Students/psychology MH - *Exercise/psychology MH - Psychometrics/methods MH - Schools MH - Factor Analysis, Statistical MH - Reproducibility of Results MH - Surveys and Questionnaires MH - Child PMC - PMC11808063 OTO - NOTNLM OT - Exercise OT - Factor structure OT - Measurement invariance OT - Middle school OT - Self-efficacy OT - Youth COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/02/10 00:19 MHDA- 2025/02/10 00:20 PMCR- 2025/02/09 CRDT- 2025/02/09 23:18 PHST- 2024/09/17 00:00 [received] PHST- 2025/02/04 00:00 [accepted] PHST- 2025/02/10 00:20 [medline] PHST- 2025/02/10 00:19 [pubmed] PHST- 2025/02/09 23:18 [entrez] PHST- 2025/02/09 00:00 [pmc-release] AID - 10.1038/s41598-025-89287-4 [pii] AID - 89287 [pii] AID - 10.1038/s41598-025-89287-4 [doi] PST - epublish SO - Sci Rep. 2025 Feb 9;15(1):4844. doi: 10.1038/s41598-025-89287-4. PMID- 39923017 OWN - NLM STAT- MEDLINE DCOM- 20250208 LR - 20250506 IS - 1866-1955 (Electronic) IS - 1866-1947 (Print) IS - 1866-1947 (Linking) VI - 17 IP - 1 DP - 2025 Feb 8 TI - Validation of the Food Safe Zone questionnaire for families of individuals with Prader-Willi syndrome. PG - 6 LID - 10.1186/s11689-024-09589-y [doi] LID - 6 AB - BACKGROUND: Prader-Willi syndrome (PWS), a genetic neurodevelopmental disorder, is characterized by hyperphagia and significant behavioral problems. Hyperphagic individuals with PWS are chronically hungry yet rarely feel sated, and often engage in food-seeking behaviors. To avoid life-threatening obesity in their children, families implement food security strategies (e.g., locking food sources, constant supervision around food, alerting others). Although widely used, these strategies have yet to be systematically examined. We thus developed and analyzed the psychometric properties of a new measure of these diverse strategies, the Food Safe Zone, and evaluated them in relation to hyperphagic symptoms and demographic variables. In doing so, we also shine a light on the extraordinary efforts of families in managing their children's hyperphagia. METHODS: Our team developed 20 FSZ items that were revised for clarity and completeness in an iterative feedback process with stakeholders, including parents, PWS specialists, and individuals with PWS. The FSZ was pilot tested, descriptive findings were reviewed by additional stakeholders, and then administered to 624 parents in a large-scale study. Based on an open-ended question, "Is there anything else you do to ensure food safety?" two additional items were added and evaluated in a follow-up study. RESULTS: Principal component analyses revealed that 21 FSZ items loaded onto 5 factors that were readily interpretable, accounting for 67% of test variance: Alerting Others and Food Supervision in the Community; Locking or Restricting Food Sources; Checking for Food; At Home Supervision and Meals; and Avoiding Food Settings. Internal consistency and test-rest reliability were robust. Convergent validity analyses revealed that parents implemented FSZ strategies in response to the severity of their child's hyperphagia, and not their child's age, gender or PWS genetic subtype. CONCLUSIONS: The psychometrically sound FSZ holds promise for future research, especially on the effects of food safety tactics on family members. In future clinical trials, the FSZ could also be used to help parents think critically about their food safety tactics in relation to their child's hyperphagia, or as an exploratory endpoint; if hyperphagia is lessened, so too may food safety tactics, thereby enhancing familial quality of life. CI - (c) 2025. The Author(s). FAU - Dykens, Elisabeth M AU - Dykens EM AD - Department of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA. Elisabeth.m.dykens@vanderbilt.edu. FAU - Roof, Elizabeth AU - Roof E AD - Department of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA. FAU - Hunt-Hawkins, Hailee AU - Hunt-Hawkins H AD - Department of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA. FAU - Strong, Theresa V AU - Strong TV AD - Foundation for Prader-Willi Research, Covina, CA, USA. LA - eng GR - P50 HD103537/HD/NICHD NIH HHS/United States GR - UL1 TR000445/TR/NCATS NIH HHS/United States PT - Journal Article PT - Validation Study DEP - 20250208 PL - England TA - J Neurodev Disord JT - Journal of neurodevelopmental disorders JID - 101483832 SB - IM MH - Humans MH - *Prader-Willi Syndrome/psychology/complications MH - Female MH - Male MH - Child MH - Psychometrics MH - *Hyperphagia/etiology/psychology/diagnosis MH - Surveys and Questionnaires MH - Adult MH - Adolescent MH - Parents/psychology MH - Child, Preschool MH - *Food Safety MH - Reproducibility of Results MH - *Family/psychology MH - *Feeding Behavior PMC - PMC11806870 OTO - NOTNLM OT - Clinical trials OT - Hyperphagia OT - PWS food safety OT - Prader-Willi syndrome COIS- Declarations. Ethics approval and consent to participate: Ethical Approval for this study was obtained by the Vanderbilt University Institutional Review Board, Integrated Science Committee, under the auspices of the University's Human Research Protections Program. Vanderbilt participants provided written, informed consent using the e-consent function of RedCap, a secure, web-based data collection platform. After consenting, parents were invited to complete 3 questionnaires on RedCap. Additional study approval was obtained for participants recruited from the Foundation for Prader-Willi Research (FPWR) Patient Registry. Prior to collecting data from the Registry, the study was reviewed and approved by FPWR's research committee and IRB. All registrants in FPWR's Patient Registry gave approval for their de-identified data to be used for research purposes. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/02/09 06:20 MHDA- 2025/02/09 06:21 PMCR- 2025/02/08 CRDT- 2025/02/08 23:24 PHST- 2024/06/12 00:00 [received] PHST- 2024/12/18 00:00 [accepted] PHST- 2025/02/09 06:21 [medline] PHST- 2025/02/09 06:20 [pubmed] PHST- 2025/02/08 23:24 [entrez] PHST- 2025/02/08 00:00 [pmc-release] AID - 10.1186/s11689-024-09589-y [pii] AID - 9589 [pii] AID - 10.1186/s11689-024-09589-y [doi] PST - epublish SO - J Neurodev Disord. 2025 Feb 8;17(1):6. doi: 10.1186/s11689-024-09589-y. PMID- 39922228 OWN - NLM STAT- MEDLINE DCOM- 20250506 LR - 20260528 IS - 1095-8304 (Electronic) IS - 0195-6663 (Print) IS - 0195-6663 (Linking) VI - 207 DP - 2025 Mar 1 TI - Applying machine learning to ecological momentary assessment data to identify predictors of loss-of-control eating and overeating severity in adolescents: A preliminary investigation. PG - 107900 LID - S0195-6663(25)00052-2 [pii] LID - 10.1016/j.appet.2025.107900 [doi] AB - OBJECTIVE: Several factors (e.g., interpersonal stress, affect) predict loss-of-control (LOC) eating and overeating in adolescents, but most past research has tested predictors separately. We applied machine learning to simultaneously evaluate multiple possible predictors of LOC-eating and overeating severity in pooled and person-specific models. METHOD: Twenty-eight adolescents (78.57% female, age = 15.87 +/- 1.59 years, BMI %ile = 92.71 +/- 8.86) who endorsed >/= two past-month LOC-eating episodes completed a week-long ecological momentary assessment protocol. Pooled models were fit to the aggregated data with elastic-net regularized regression and evaluated using nested cross-validation. Person-specific models were fit and evaluated as proof-of-concept. RESULTS: Across adolescents, the median out-of-sample R(2) of the pooled LOC-eating severity model was .33. The top predictors were between-subjects food craving, sadness, interpersonal conflict, shame, distress, stress (inverse association), and anger (inverse association), and within- and between-subjects wishing relationships were better. The median out-of-sample R(2) for pooled overeating severity model was .20. The top predictors were between-person food craving, loneliness, mixed race, and feeling rejected (inverse association), and within-subjects guilt, nervousness, wishing for more friends (inverse association), and feeling scared, annoyed, and rejected (all inverse associations). Person-specific models demonstrated poor fit (median LOC-eating severity R(2) = .003, median overeating R(2) = -.009); 61% and 36% of adolescents' models performed better than chance for LOC-eating and overeating severity, respectively. DISCUSSION: Altogether, group-level models may hold utility in predicting LOC-eating and overeating severity, but model performance for person-specific models is variable, and additional research with larger samples over an extended assessment period is needed. Ultimately, a mix of these approaches may improve the identification of momentary predictors of LOC eating and overeating, providing novel and personalized opportunities for intervention. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - Hagan, Kelsey AU - Hagan K AD - Department of Psychiatry, New York State Psychiatric Institute, Columbia University Irving Medical Center, New York, NY, USA; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA; Institute for Women's Health, Virginia Commonwealth University, Richmond, VA, USA. FAU - Leenaerts, Nicolas AU - Leenaerts N AD - Department of Psychiatry, Mind-Body Research Center, KU Leuven, Belgium; Leuven Brain Institute, KU Leuven, Belgium. FAU - Walsh, B Timothy AU - Walsh BT AD - Department of Psychiatry, New York State Psychiatric Institute, Columbia University Irving Medical Center, New York, NY, USA. FAU - Ranzenhofer, Lisa AU - Ranzenhofer L AD - Department of Psychiatry, New York State Psychiatric Institute, Columbia University Irving Medical Center, New York, NY, USA; Department of Psychiatry, University of Buffalo, Buffalo, NY, USA. Electronic address: lisaranz@buffalo.edu. LA - eng GR - K12 AR084233/AR/NIAMS NIH HHS/United States GR - K23 MH121780/MH/NIMH NIH HHS/United States GR - R03 HD090206/HD/NICHD NIH HHS/United States GR - T32 MH096678/MH/NIMH NIH HHS/United States PT - Journal Article DEP - 20250206 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - Adolescent MH - *Ecological Momentary Assessment MH - *Hyperphagia/psychology MH - Male MH - *Machine Learning MH - *Feeding Behavior/psychology MH - Stress, Psychological/psychology MH - Severity of Illness Index MH - *Adolescent Behavior/psychology MH - Craving PMC - PMC11884998 MID - NIHMS2056053 OTO - NOTNLM OT - Adolescence OT - Eating disorders OT - Ecological momentary assessment OT - Loss-of-control eating OT - Machine learning OT - Overeating COIS- Declaration of competing interest This research was supported by the National Institutes of Health (R03 HD090206; K23 MH121780; K12AR084233; T32 MH096678) and the Special Research Fund KU Leuven (ECA-D4671- C14/18/096). The sponsors did not have a role in the collection, analysis, and interpretation of data, writing of this manuscript, nor the decision to submit this manuscript for publication. The content is solely the authors' responsibility and does not necessarily represent the views of respective funding agencies. Dr. Hagan reports honoraria from the Association for Child and Adolescent Mental Health. Dr. Walsh reports receiving royalties and honoraria from Guilford Publications, McGraw-Hill, Johns Hopkins University Press, Oxford University Press, UpToDate, Wiley, the University of British Columbia, Guidepoint Global, Silverhill Hospital, the University of Alabama, the American Society for Clinical Psychopharmacology, Health Advances, and Dell Medical School. Drs. Leenaerts and Ranzenhofer report no biomedical financial interests or potential conflicts of interest. EDAT- 2025/02/09 06:20 MHDA- 2025/03/06 05:05 PMCR- 2026/03/01 CRDT- 2025/02/08 19:29 PHST- 2024/08/13 00:00 [received] PHST- 2025/02/04 00:00 [revised] PHST- 2025/02/05 00:00 [accepted] PHST- 2025/03/06 05:05 [medline] PHST- 2025/02/09 06:20 [pubmed] PHST- 2025/02/08 19:29 [entrez] PHST- 2026/03/01 00:00 [pmc-release] AID - S0195-6663(25)00052-2 [pii] AID - 10.1016/j.appet.2025.107900 [doi] PST - ppublish SO - Appetite. 2025 Mar 1;207:107900. doi: 10.1016/j.appet.2025.107900. Epub 2025 Feb 6. PMID- 39919050 OWN - NLM STAT- MEDLINE DCOM- 20250506 LR - 20261015 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 2 DP - 2025 TI - Perceived barriers to physical activity and their predictors among adults in the Central Region in Saudi Arabia: Gender differences and cultural aspects. PG - e0318798 LID - 10.1371/journal.pone.0318798 [doi] LID - e0318798 AB - OBJECTIVE: To assess the perceived barriers hindering physical activity among adult residents of Riyadh, Saudi Arabia, and to identify associated sociodemographic and health-related factors, focusing on gender differences and cultural aspects. METHODS: A cross-sectional survey was conducted from the 9th of January 2022 to the 2nd of February 2023, involving 7,903 physically inactive participants aged 18 to 80. Participants were recruited using a two-stage cluster sampling method from the Central Region of Saudi Arabia. In the first stage, subregions based on the administrative distribution by the Medical Service Department were selected. In the second stage, private and public entities within these subregions were identified from governmental agency lists. Participants were then conveniently approached within these entities. Data were collected using a validated questionnaire, the Perceived Barriers to Being Active Questionnaire (PBAQ), assessing sociodemographic characteristics, health history, dietary habits, and perceived internal and external barriers to physical activity. RESULTS: Of the participants, 67.2% were male, with a mean age of 36.45 +/- 13.69 years. Approximately one-third (35%) reported experiencing at least one internal barrier to physical activity, while 64.3% reported 1-2 internal barriers. For external barriers, 76.5% faced 1-2 barriers. The most common internal barriers were laziness (40.2%) and lack of self-motivation (27.5%); the most prevalent external barriers were lack of facilities (20.2%) and long working hours (19.6%). Females were significantly more likely than males to report cultural reasons (odds ratio [OR] = 4.83; 95% confidence interval [CI]: 4.06-5.76; p < 0.001) and religious reasons (OR = 3.31; 95% CI: 2.59-4.23; p < 0.001) as internal barriers. Multivariate analysis revealed that females were 14% more likely than males to report external barriers to physical activity (OR = 1.14; 95% CI: 1.04-1.25; p = 0.018), suggesting gender plays a role in perceived external obstacles. Additionally, older age, higher body mass index, higher education level, marriage, certain employment statuses, and chronic diseases were significantly associated with increased reported internal and external barriers. These findings highlight the complex interplay of demographic and health-related factors influencing physical activity participation. CONCLUSIONS: There is a high prevalence of both internal and external barriers to physical activity among Saudi adults, with notable gender differences influenced by cultural factors. Females were more likely to report cultural and religious reasons as barriers. Tailored policies and interventions are urgently needed to address these barriers, such as promoting gender-specific physical activity programs, integrating physical activity into workplaces, enhancing public facilities, and conducting culturally sensitive educational campaigns. Addressing both internal motivations and external obstacles is essential to increase physical activity levels and combat the rising burden of non-communicable diseases in Saudi Arabia. CI - Copyright: (c) 2025 Abdelhay et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Abdelhay, Osama AU - Abdelhay O AUID- ORCID: 0000-0003-2339-1406 AD - Department of Data Science, King Hussein School of Computing Sciences, Princess Sumaya University for Technology, Amman, Jordan. AD - Department of Family & Community Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. FAU - Altamimi, Mohammad AU - Altamimi M AD - Department of Nutrition and Food Technology, An-Najah National University, Nablus, Palestine. FAU - Abdelhay, Qusai AU - Abdelhay Q AD - Department of Orthopaedic Surgery, Al-Bashir Hospital, Amman, Jordan. FAU - Manajrah, Marwan AU - Manajrah M AD - Department of Family & Community Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. FAU - Tourkmani, Ayla M AU - Tourkmani AM AD - Department of Family & Community Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. FAU - Altamimi, Mutaz AU - Altamimi M AD - King Hussein Cancer Centre, Amman, Jordan. FAU - Altamimi, Taghreed AU - Altamimi T AD - Department of Software Engineering, Al Faisal University, Riyadh, Saudi Arabia. LA - eng PT - Journal Article DEP - 20250207 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM EIN - PLoS One. 2025 Sep 3;20(9):e0331572. doi: 10.1371/journal.pone.0331572. PMID: 40901819 MH - Humans MH - Male MH - Female MH - Saudi Arabia MH - Adult MH - *Exercise/psychology MH - Middle Aged MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - Young Adult MH - Adolescent MH - Sex Factors MH - Aged MH - Aged, 80 and over PMC - PMC11805373 COIS- The authors have declared that no competing interests exist. EDAT- 2025/02/07 18:20 MHDA- 2025/02/07 18:21 PMCR- 2025/02/07 CRDT- 2025/02/07 13:33 PHST- 2024/10/02 00:00 [received] PHST- 2025/01/19 00:00 [accepted] PHST- 2025/02/07 18:21 [medline] PHST- 2025/02/07 18:20 [pubmed] PHST- 2025/02/07 13:33 [entrez] PHST- 2025/02/07 00:00 [pmc-release] AID - PONE-D-24-42926 [pii] AID - 10.1371/journal.pone.0318798 [doi] PST - epublish SO - PLoS One. 2025 Feb 7;20(2):e0318798. doi: 10.1371/journal.pone.0318798. eCollection 2025. PMID- 39918169 OWN - NLM STAT- MEDLINE DCOM- 20250512 LR - 20260824 IS - 1098-108X (Electronic) IS - 0276-3478 (Print) IS - 0276-3478 (Linking) VI - 58 IP - 5 DP - 2025 May TI - Validating Online Parent- and Self-Report Screening Methods for Avoidant/Restrictive Food Intake Disorder. PG - 878-889 LID - 10.1002/eat.24376 [doi] AB - OBJECTIVE: Although several assessments have been developed to diagnose or measure avoidant/restrictive food intake disorder (ARFID) symptoms, few studies have validated these tools in nonclinical and adult samples. This study explored the validity of two self- and parent/guardian-report ARFID screening measures in identifying adults and children who may have ARFID within a large community sample. METHOD: Fifty participants (divided into two groups: 25 adults and 25 parents/guardians of children) were selected from the ARFID Genes and Environment study, which enrolled over 3000 adults and parents/guardians of children who screened positive for ARFID on either the Pica, ARFID, and Rumination Disorder Interview-ARFID Questionnaire (PARDI-AR-Q) or the Nine Item ARFID Screen (NIAS) self- and parent/guardian-report measures. Participants then completed the ARFID portion of the Pica, ARFID, and Rumination Disorder Interview (PARDI) to determine ARFID diagnosis. RESULTS: Correlations between the PARDI-AR-Q and PARDI (r = 0.31-0.67) were weaker than the correlations between the NIAS and PARDI (r = 0.53-0.64) in both groups. The diagnostic positive predictive value for the PARDI-AR-Q was numerically higher (adults = 55.0%; parents/guardians = 76.0%) than the NIAS (adults = 45.8%; parents/guardians = 64.0%). Most PARDI-AR-Q dimensions and all NIAS dimensions were significant predictors of their corresponding PARDI dimensions in both groups. DISCUSSION: The PARDI-AR-Q more accurately identified adults and children with ARFID, whereas the NIAS was a better estimator of ARFID symptoms. These findings provide partial support for using these self- and parent/guardian-report screeners. Results highlight the need to better understand diagnostic presentations of ARFID within community samples, particularly in adults, and to refine these tools within those populations. CI - (c) 2025 Wiley Periodicals LLC. FAU - Ortiz, Shelby N AU - Ortiz SN AUID- ORCID: 0000-0001-8088-8254 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - White, Jennifer P AU - White JP AUID- ORCID: 0009-0009-2284-4240 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - MacDermod, Casey M AU - MacDermod CM AUID- ORCID: 0009-0008-4207-1823 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Dinkler, Lisa AU - Dinkler L AUID- ORCID: 0000-0002-9901-4984 AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Thornton, Laura M AU - Thornton LM AUID- ORCID: 0000-0001-9384-7988 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Johnson, Jessica AU - Johnson J AUID- ORCID: 0000-0002-4519-3120 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Guintivano, Jerry D AU - Guintivano JD AUID- ORCID: 0000-0003-3541-1101 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Baker, Jessica H AU - Baker JH AUID- ORCID: 0000-0002-3997-2398 AD - Equip Health, Carlsbad, California, USA. FAU - Bulik, Cynthia M AU - Bulik CM AUID- ORCID: 0000-0001-7772-3264 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. AD - Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Micali, Nadia AU - Micali N AUID- ORCID: 0000-0001-5571-2273 AD - Mental Health Services of the Capital Region of Denmark, Copenhagen, Denmark. AD - Great Ormond Street Institute of Child Health, University College London, London, UK. FAU - Pisetsky, Emily M AU - Pisetsky EM AUID- ORCID: 0000-0002-3296-5304 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. LA - eng GR - R01 MH124871/MH/NIMH NIH HHS/United States GR - R56 MH129437/MH/NIMH NIH HHS/United States GR - R56MH129437/MH/NIMH NIH HHS/United States GR - PG-22-0478/Svenska Sallskapet for Medicinsk Forskning/ PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250207 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM MH - Humans MH - Female MH - Male MH - Adult MH - *Parents/psychology MH - *Self Report MH - Surveys and Questionnaires MH - *Avoidant Restrictive Food Intake Disorder/diagnosis MH - Middle Aged MH - Young Adult MH - Child MH - Adolescent MH - Reproducibility of Results MH - *Feeding and Eating Disorders/diagnosis MH - Internet PMC - PMC12670330 MID - NIHMS2124090 OTO - NOTNLM OT - ARFID OT - appetite OT - clinical assessment OT - eating disorders OT - fear OT - picky eating EDAT- 2025/02/07 12:25 MHDA- 2025/05/12 12:34 PMCR- 2025/12/02 CRDT- 2025/02/07 07:33 PHST- 2024/11/26 00:00 [revised] PHST- 2024/09/30 00:00 [received] PHST- 2024/12/20 00:00 [accepted] PHST- 2025/05/12 12:34 [medline] PHST- 2025/02/07 12:25 [pubmed] PHST- 2025/02/07 07:33 [entrez] PHST- 2025/12/02 00:00 [pmc-release] AID - 10.1002/eat.24376 [doi] PST - ppublish SO - Int J Eat Disord. 2025 May;58(5):878-889. doi: 10.1002/eat.24376. Epub 2025 Feb 7. PMID- 39917271 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250208 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 7 DP - 2025 TI - Test-retest reliability of postural control measures in healthy secondary school pupils: insights from the MOVE12 pilot study. PG - 1521252 LID - 10.3389/fspor.2025.1521252 [doi] LID - 1521252 AB - INTRODUCTION: Postural control is an essential part of human movement. Measurements of center of pressure displacements by force platform are considered the gold standard for assessing postural control. However, the test-retest reliability of these measurements in field-based conditions is unclear. METHODS: This study aimed to investigate the test-retest reliability of center of pressure measures under field-based conditions, and assess the impact of height, weight, and body mass index (BMI) on test-retest reliability. The study sample comprised 215 upper secondary school pupils (114 girls) aged 16-17 years, all drawn from the control group of a larger intervention study. There was a 12-week interval between the initial test and the retest. Measurements of center of pressure displacements was assessed during a bipedal eyes closed and a unipedal eyes open condition. Interclass correlation coefficients (ICCs) with 95% confidence intervals were calculated for six distinct measures in both conditions. Correlations between the change in postural control and height, weight, and BMI were assessed as well. RESULTS: Trace length exhibited the best test-retest reliability in both conditions, achieving moderate to good reliability in the bipedal eyes closed condition (ICC = 0.73, 95% CI = 0.66-0.78). Test-retest reliability was higher for all measures in the bipedal eyes closed (ICC's = 0.53-0.73) compared to unipedal eyes open condition, and some of these measures approached zero reliability (ICC's = 0.03-0.48). Among body characteristics, only height was significantly correlated with test-retest changes in postural control (r = 0.16, p < 0.05) and only for two of the measures. DISCUSSION: This study underscores the necessity of careful selection of postural control measures and thorough assessments in field-based research to achieve acceptable test-retest reliability. CI - (c) 2025 Litleskare and Barene. FAU - Litleskare, Sigbjorn AU - Litleskare S AD - Department of Public Health and Sport Sciences, University of Inland Norway, Elverum, Norway. AD - Centre for Health and Technology, University of South-Eastern Norway, Drammen, Norway. FAU - Barene, Svein AU - Barene S AD - Department of Public Health and Sport Sciences, University of Inland Norway, Elverum, Norway. LA - eng PT - Journal Article DEP - 20250123 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC11798880 OTO - NOTNLM OT - centre of gravity OT - centre of pressure OT - postural instability OT - postural stability OT - postural sway COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/02/07 11:12 MHDA- 2025/02/07 11:13 PMCR- 2025/01/23 CRDT- 2025/02/07 04:53 PHST- 2024/11/01 00:00 [received] PHST- 2025/01/09 00:00 [accepted] PHST- 2025/02/07 11:13 [medline] PHST- 2025/02/07 11:12 [pubmed] PHST- 2025/02/07 04:53 [entrez] PHST- 2025/01/23 00:00 [pmc-release] AID - 10.3389/fspor.2025.1521252 [doi] PST - epublish SO - Front Sports Act Living. 2025 Jan 23;7:1521252. doi: 10.3389/fspor.2025.1521252. eCollection 2025. PMID- 39916720 OWN - NLM STAT- MEDLINE DCOM- 20250506 LR - 20250506 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Impact of neighborhood safety on adolescent physical activity in Saudi Arabia: gender and socio-economic perspectives. PG - 1520851 LID - 10.3389/fpubh.2025.1520851 [doi] LID - 1520851 AB - BACKGROUND AND OBJECTIVES: Adolescent physical activity is a critical determinant of long-term physical and mental health. However, the factors influencing activity levels remain underexplored in rapidly urbanizing regions such as Saudi Arabia, where changing built environments pose unique challenges. METHODS: This study examined the relationship between neighborhood safety perceptions and physical activity levels among 1,500 adolescents aged 14-17 years in the cities of Riyadh, Jeddah, and Dammam, representing a mix of urban and suburban settings. This study used a cross-sectional design with data collected through a validated self-reported questionnaires and interviews; the data were analyzed through multivariate regression. RESULTS: The results indicate that adolescents who perceived higher traffic-related safety concerns engaged in 30% less physical activity compared to those in safer neighborhoods (p < 0.01). Female adolescents were 20% more likely than male adolescents to report safety concerns (p < 0.05), while those residing in villas engaged in 15% more physical activity than their peers living in flats (p < 0.05). CONCLUSIONS: These findings underscore the significant role of neighborhood safety in shaping adolescent health behaviors, particularly regarding traffic management and accessibility. These results contribute to the growing evidence regarding the influence of built environments on youth health and wellbeing in rapidly urbanizing regions. The study offers actionable policy recommendations for urban planners and public health officials to create safer, more inclusive environments that encourage physical activity, especially among female adolescents. Future research should adopt longitudinal designs and incorporate objective measures, such as wearable activity trackers, to assess the long-term impact of neighborhood safety interventions on adolescent health outcomes. CI - Copyright (c) 2025 Addas. FAU - Addas, Abdullah AU - Addas A AD - Department of Civil Engineering, College of Engineering, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia. AD - Landscape Architecture Department, Faculty of Architecture and Planning, King Abdulaziz University, Jeddah, Saudi Arabia. LA - eng PT - Journal Article DEP - 20250123 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Adolescent MH - Saudi Arabia MH - Female MH - Male MH - *Exercise/psychology MH - Cross-Sectional Studies MH - *Safety/statistics & numerical data MH - *Residence Characteristics/statistics & numerical data MH - Sex Factors MH - Surveys and Questionnaires MH - *Neighborhood Characteristics/statistics & numerical data MH - Socioeconomic Factors MH - *Adolescent Behavior/psychology PMC - PMC11798916 OTO - NOTNLM OT - Saudi Arabia OT - adolescent physical activity OT - community engagement OT - neighborhood safety OT - residential environment COIS- The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/02/07 11:12 MHDA- 2025/02/07 11:13 PMCR- 2025/01/23 CRDT- 2025/02/07 04:45 PHST- 2024/10/31 00:00 [received] PHST- 2025/01/07 00:00 [accepted] PHST- 2025/02/07 11:13 [medline] PHST- 2025/02/07 11:12 [pubmed] PHST- 2025/02/07 04:45 [entrez] PHST- 2025/01/23 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1520851 [doi] PST - epublish SO - Front Public Health. 2025 Jan 23;13:1520851. doi: 10.3389/fpubh.2025.1520851. eCollection 2025. PMID- 39915865 OWN - NLM STAT- MEDLINE DCOM- 20250506 LR - 20250815 IS - 2072-1315 (Electronic) IS - 1606-0997 (Print) IS - 1606-0997 (Linking) VI - 44 IP - 1 DP - 2025 Feb 6 TI - Factors associated with caffeine intake among undergraduates: a cross-sectional study from Palestine. PG - 26 LID - 10.1186/s41043-024-00723-z [doi] LID - 26 AB - BACKGROUND: Caffeine is one of the world's most frequently consumed central nervous system stimulants. Moderate caffeine intake has beneficial health effects, while increased caffeine intake may have harmful effects in the human body. Existing literature indicated that undergraduates consume caffeine excessively. Till this date, little is known about the consumption pattern of caffeine among Palestinian undergraduates. Therefore, the current study aimed to estimate the percentage of caffeine consumption among Palestinian undergraduates, to assess their caffeine daily intake, and to identify factors associated with unsafe caffeine consumption. METHODS: A cross-sectional study was conducted in Palestine between March and May 2022. Undergraduates were recruited by random sampling after a personal invitation. Undergraduates aged between 18 and 25 were included in the study, while those who were taking medications, had medical conditions affecting the data collection process, and had incomplete responses were excluded from the study. Caffeine consumption was assessed using a semi-quantitative food frequency questionnaire (FFQ) developed by the research team. The content validity of the FFQ was done by three reviewers. Also, a questionnaire was used to collect data related to sociodemographic characteristics, medical history, lifestyle habits, sleeping quality, physical activity, and psychological status. Data were analyzed through the descriptive statistics and inferential statistics (Chi-square test, Mann-Whitney test, and Kruskal-Wallis H test). RESULTS: The final analysis included 486 undergraduates with a mean age of 20.1 +/- 1.48 years. The majority of the undergraduates were female (65.0%) and single (89.5%). The sample was distributed almost equally between the first (26.3%), second (23.0%), third (22.8%), and fourth (18.7%) academic years, and only 44 undergraduates (9.1%) were in their fifth year. The vast majority of university students (96.5%) consumed caffeinated products, with coffee ranking first place. Nearly half of the participants (32.7%) exceeded the safe levels of caffeine consumption. Males, smokers, poor physical activity, higher Sleep Hygiene Index (SHI) scores, and greater anxiety, stress, and depression scores had significantly higher rates of unsafe caffeine intake than their peers (p < 0.05). The total caffeine consumption was significantly associated with gender, low household income, smoking status, physical activity level, SHI score, as well as anxiety (p < 0.05). CONCLUSION: Caffeine consumption in the studied sample was significantly high and exceeded the safe levels. The current study revealed that unsafe caffeine consumption was more common among males, smokers, and physically active individuals. Caffeine intake was also linked to poor-quality sleep and higher psychological concerns. Therefore, educational programs are recommended to increase awareness of the adverse effects of high caffeine intake. CI - (c) 2024. The Author(s). FAU - Hamdan, May AU - Hamdan M AD - Faculty of Medicine, Department of Health Professions, Program of Healthy and Therapeutic Nutrition, Palestine Polytechnic University, Hebron, Palestine. FAU - Zidan, Souzan AU - Zidan S AD - Department of Nutrition and Food Technology, Faculty of Agriculture, Hebron University, Hebron, West Bank, Palestine. FAU - Al-Amouri, Fatima AU - Al-Amouri F AD - Department of Nutrition and Food Technology, Faculty of Agriculture and Veterinary Medicine, An-Najah National University, Nablus, West Bank, Palestine. FAU - Niroukh, Hiba AU - Niroukh H AD - Faculty of Medicine, Department of Health Professions, Program of Healthy and Therapeutic Nutrition, Palestine Polytechnic University, Hebron, Palestine. FAU - Dawod, Manar Abu AU - Dawod MA AD - Faculty of Medicine, Department of Health Professions, Program of Healthy and Therapeutic Nutrition, Palestine Polytechnic University, Hebron, Palestine. FAU - Ashour, Sajeda AU - Ashour S AD - Faculty of Medicine, Department of Health Professions, Program of Healthy and Therapeutic Nutrition, Palestine Polytechnic University, Hebron, Palestine. FAU - Dweik, Shahd Sameer AU - Dweik SS AD - Faculty of Medicine, Department of Health Professions, Program of Healthy and Therapeutic Nutrition, Palestine Polytechnic University, Hebron, Palestine. FAU - Badrasawi, Manal AU - Badrasawi M AD - Department of Nutrition and Food Technology, Faculty of Agriculture and Veterinary Medicine, An-Najah National University, Nablus, West Bank, Palestine. m.badrasawi@najah.edu. LA - eng PT - Journal Article DEP - 20250206 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 RN - 3G6A5W338E (Caffeine) RN - 0 (Central Nervous System Stimulants) SB - IM MH - Humans MH - *Caffeine/administration & dosage MH - Cross-Sectional Studies MH - Female MH - Male MH - Young Adult MH - *Students/statistics & numerical data/psychology MH - Adult MH - *Arabs/statistics & numerical data MH - Adolescent MH - Surveys and Questionnaires MH - Universities MH - Middle East MH - Central Nervous System Stimulants/administration & dosage MH - Life Style PMC - PMC11803939 OTO - NOTNLM OT - Association OT - Caffeine consumption OT - Cross sectional study OT - Psychological status OT - University students COIS- Declarations. Ethical approval: The research protocols were in accordance with the Declaration of Helsinki and reported in line with the STROBE checklist for reporting cross-sectional studies. The study protocol was approved by the Deanship of Scientific Research Ethical Committee at Palestine Polytechnic University (approval code: KA/41/2022). Informed written was also collected from all undergraduates before data collection. All the collected data were saved secretly, allowing only the principal investigators and the study analyst to evaluate and conduct the proper statistical analysis. Note that participant names were not saved to avoid violating participants confidentiality. After this study was finished, the data were saved by the principal investigators correctly which may benefit any future similar or related studies. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/02/07 00:20 MHDA- 2025/02/07 11:12 PMCR- 2025/02/06 CRDT- 2025/02/06 23:42 PHST- 2024/04/01 00:00 [received] PHST- 2024/12/14 00:00 [accepted] PHST- 2025/02/07 11:12 [medline] PHST- 2025/02/07 00:20 [pubmed] PHST- 2025/02/06 23:42 [entrez] PHST- 2025/02/06 00:00 [pmc-release] AID - 10.1186/s41043-024-00723-z [pii] AID - 723 [pii] AID - 10.1186/s41043-024-00723-z [doi] PST - epublish SO - J Health Popul Nutr. 2025 Feb 6;44(1):26. doi: 10.1186/s41043-024-00723-z. PMID- 39915098 OWN - NLM STAT- MEDLINE DCOM- 20250710 LR - 20260813 IS - 1528-1132 (Electronic) IS - 0009-921X (Print) IS - 0009-921X (Linking) VI - 483 IP - 7 DP - 2025 Feb 6 TI - Can We Accurately Predict Adult Height in Pediatric Patients Who Undergo Treatment for Sarcoma? PG - 1338-1346 LID - 10.1097/CORR.0000000000003409 [doi] AB - BACKGROUND: Sarcoma and its treatment has the potential to limit adult height attainment in skeletally immature patients. However, evidence on the extent of this limitation in sarcoma specifically is mixed, and existing height prediction tools such as the Paley multiplier method have proven unreliable in this setting. As such, orthopaedic surgeons are left with the challenge of counseling patients and their families on expected height deficits without an adequate understanding of the extent of these deficits. Equally important, these surgeons must also understand the amount of skeletal growth remaining during the presurgical planning process for limb reconstruction to adequately grasp a patient's risk of subsequent limb length discrepancy. QUESTIONS/PURPOSES: (1) To what extent does pediatric sarcoma and its treatment limit adult height attainment? (2) Using retrospective data on pediatric patients with sarcoma, can we create a height prediction model that yields more accurate estimates of expected adult height than the Paley multiplier method? METHODS: For this retrospective pilot study, 223 pediatric patients with sarcoma from a single pediatric sarcoma center between 1976 and June 2022 were identified using diagnostic codes. Inclusion criteria were completion of chemotherapy before skeletal maturity, survival to maturity, and complete height data (that is, height at diagnosis and at skeletal maturity). Of the 223 patients identified as potentially eligible, 56 met inclusion criteria. The remaining 167 patients were excluded on the basis of not receiving chemotherapy (9% [15 of 167]), receiving chemotherapy after skeletal maturity was reached (20% [33 of 167]), not surviving to skeletal maturity (19% [31 of 167]), not reaching skeletal maturity at the time of chart review (43% [72 of 167]), having insufficient treatment data available for analysis (7% [11 of 167]), or being lost to follow-up (that is, no further clinic visits where height at skeletal maturity was recorded) (3% [5 of 167]). Data collection encompassed cancer type; age, height, and weight at diagnosis and maturity; and treatment characteristics. A total of 43% (24 of 56) were female and 57% (32 of 56) were male. Among included patients, 70% (39 of 56) had primary bone tumors, of which 64% (25 of 39) involved lower extremity. Diagnoses of osteosarcoma (41% [23 of 56]) and Ewing sarcoma (36% [20 of 56]) predominated. Doxorubicin (82% [46 of 56]) and cyclophosphamide (61% [34 of 56]) were the most common chemotherapeutics; the mean +/- SD treatment duration was 76 +/- 88 weeks. Female patients were diagnosed at a mean age of 11 +/- 4 years, reaching skeletal maturity at 16 +/- 1 years. Male patients were diagnosed at a mean age of 14 +/- 3 years, reaching skeletal maturity at 17 +/- 1 years. We compared CDC z-scores, which quantify patient height relative to the population mean using SD and percentiles, at diagnosis and maturity to track growth before and after sarcoma treatment, thus quantifying our cohort's growth trajectories relative to the population mean. The Paley multiplier method is a quick and easy-to-use limb length prediction tool that utilizes validated age- and sex-specific multipliers. Its predictions based on height at diagnosis were compared with final attained heights. A novel height prediction model accounting for chemotherapy was derived via multiple regression using two-thirds of the cohort. The remaining one-third was used to test accuracy of the model. RESULTS: Skeletally immature patients diagnosed with and treated for sarcoma were found to achieve shorter heights at maturity than predicted by the Paley method and CDC growth curves. The Paley method overpredicted adult height by a mean +/- SD of 4.3 +/- 5.9 cm in female patients (95% confidence interval 1.8 to 6.8; p < 0.001) and 4.9 +/- 6.1 cm in male patients (95% CI 2.6 to 7.1; p < 0.001). Median (range) CDC z-scores at maturity (0.47 [-1.7 to 3.2]) were lower than at diagnosis (0.73 [-1.7 to 2.6]) (median difference -0.26; p < 0.001). Patients diagnosed at younger ages were more likely to have larger discrepancies in both CDC z-scores at maturity and in predicted heights. Our novel height prediction model yielded predictions most similar to actual heights attained by incorporating sex, age at first chemotherapy, and height at diagnosis into the following equation (result given in centimeters): 116 + 12 (if male) + 0.6 x (height at diagnosis in cm) - 3.2 x (age at first chemotherapy in years). CONCLUSION: Our novel height prediction model more accurately accounts for growth limitations imposed by pediatric sarcoma treatment compared with the Paley method and CDC z-scores. With our model, surgeons are now better equipped to plan complex surgical reconstruction of lower extremity tumors in growing children because of a better grasp of eventual adult height and, relatedly, risk for limb length discrepancies. However, to identify any factors that may influence the model's accuracy, larger studies with more diverse cohorts are needed.Level of Evidence Level IV, therapeutic study. CI - Copyright (c) 2025 by the Association of Bone and Joint Surgeons. FAU - Prigmore, Brian AU - Prigmore B AD - Oregon Health & Science University School of Medicine, Portland, OR, USA. FAU - Lindsay, Sarah E AU - Lindsay SE AUID- ORCID: 0000-0002-4452-002 AD - Department of Orthopaedics and Rehabilitation, Oregon Health & Science University, Portland, OR, USA. FAU - Agloro, Anna AU - Agloro A AD - Oregon Health & Science University School of Medicine, Portland, OR, USA. FAU - Doung, Yee-Cheen AU - Doung YC AD - Department of Orthopaedics and Rehabilitation, Oregon Health & Science University, Portland, OR, USA. FAU - Gundle, Kenneth R AU - Gundle KR AD - Department of Orthopaedics and Rehabilitation, Oregon Health & Science University, Portland, OR, USA. FAU - Hayden, James B AU - Hayden JB AD - Department of Orthopaedics and Rehabilitation, Oregon Health & Science University, Portland, OR, USA. FAU - Ramsey, Duncan C AU - Ramsey DC AUID- ORCID: 0000-0003-2058-9556 AD - Department of Orthopaedics and Rehabilitation, Oregon Health & Science University, Portland, OR, USA. LA - eng PT - Journal Article DEP - 20250206 PL - United States TA - Clin Orthop Relat Res JT - Clinical orthopaedics and related research JID - 0075674 SB - IM CIN - doi: 10.1097/CORR.0000000000003462 MH - Humans MH - Retrospective Studies MH - Female MH - Male MH - Child MH - *Body Height MH - *Sarcoma/therapy/physiopathology MH - Adolescent MH - *Bone Neoplasms/therapy MH - Pilot Projects MH - Child, Preschool MH - Age Factors MH - Predictive Value of Tests MH - Adult PMC - PMC12190102 COIS- Each author certifies that there are no funding or commercial associations (consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article related to the author or any immediate family members. All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research(R) editors and board members are on file with the publication and can be viewed on request. EDAT- 2025/02/07 00:20 MHDA- 2025/07/10 12:31 PMCR- 2026/07/01 CRDT- 2025/02/06 21:43 PHST- 2024/08/27 00:00 [received] PHST- 2025/01/21 00:00 [accepted] PHST- 2025/07/10 12:31 [medline] PHST- 2025/02/07 00:20 [pubmed] PHST- 2025/02/06 21:43 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - 00003086-990000000-01899 [pii] AID - CORR-D-24-01022 [pii] AID - 10.1097/CORR.0000000000003409 [doi] PST - epublish SO - Clin Orthop Relat Res. 2025 Feb 6;483(7):1338-1346. doi: 10.1097/CORR.0000000000003409. PMID- 39915022 OWN - NLM STAT- MEDLINE DCOM- 20250206 LR - 20250624 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 2 DP - 2025 Feb 6 TI - Effects of exercise and exercise timing on energy intake and appetite control in Danish individuals with overweight or obesity with and without type 2 diabetes: a protocol for a randomised controlled cross-over trial. PG - e092683 LID - 10.1136/bmjopen-2024-092683 [doi] LID - e092683 AB - INTRODUCTION: The aim of this study is to investigate the effects of acute exercise on appetite control and whether this differs between morning and late afternoon in individuals with overweight/obesity with or without type 2 diabetes (T2D). METHODS AND ANALYSIS: The hedonic and homeostatic appetite control in obesity and type 2 diabetes in the context of meal and exercise timing (TIMEX) study is a randomised, controlled, cross-over trial. Fifty-eight women and men (aged 18-75 years) with overweight or obesity (body mass index >/=25 kg/m(2)) with or without T2D will be recruited. All participants will complete a screening and baseline visit followed by four test visits: two morning visits and two late afternoon visits. The participants will arrive in the fasted state during the visits. During one morning visit and one late afternoon visit, the participants will engage in a 45-min bout of acute high-intensity interval exercise on an ergometer bicycle. The remaining two visits (one morning and one late afternoon visit) will include 45 min of rest. Fifteen minutes after the rest or exercise period, the participants will be presented with an ad libitum meal. Blood samples will be collected and subjective appetite will be assessed using Visual Analogue Scales in the fasted state before exercise/rest, immediately post-exercise/rest and at 15, 30, 45 and 60 min post-exercise/rest. Food reward and food preferences will be assessed using the validated diurnal version of the Steno Biometric Food Preference Task in the fasted state before exercise/rest and 15 min after the ad libitum meal (45 min post-exercise/rest). The primary outcome is the difference in ad libitum energy intake after exercise compared with rest. Secondary outcomes include eating rate; 24-hour energy intake; appetite-related metabolites and hormones, and circulating biomarkers assessed from proteomics, metabolomics and lipidomics analyses; food choice, food attention and reaction time, explicit and implicit liking and wanting for different food categories, subjective appetite; ratings of perceived exertion during exercise. All outcomes will be compared between morning and late afternoon and between participants with and without T2D. ETHICS AND DISSEMINATION: The study has been approved by the Ethics Committee of the Capital Region of Denmark (H-22019913) and the Capital Region of Denmark's Research Register (Privacy). The study will be conducted in accordance with the Declaration of Helsinki. All results will be published in national and international peer-reviewed journals and will be disseminated at national and international conferences. TRIAL REGISTRATION NUMBER: NCT05768958. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Jalking, Lea AU - Jalking L AD - Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Herlev, Denmark. FAU - Launbo, Natja Poder AU - Launbo NP AUID- ORCID: 0000-0002-5717-1631 AD - Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Herlev, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. FAU - Jensen, Marie Moller AU - Jensen MM AUID- ORCID: 0000-0003-2660-3240 AD - Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Herlev, Denmark. FAU - Pedersen, Hanne Enghoff AU - Pedersen HE AD - Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Herlev, Denmark. AD - Novo Nordisk A/S, Soborg, Denmark. FAU - Blond, Martin Baek AU - Blond MB AD - Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Herlev, Denmark. FAU - Gerstenberg, Marina Kjaergaard AU - Gerstenberg MK AD - Translational Medicine, Global Translation, Novo Nordisk A/S, Malov, Denmark. FAU - Finlayson, Graham AU - Finlayson G AUID- ORCID: 0000-0002-5620-2256 AD - School of Psychology, University of Leeds, Leeds, UK. FAU - Beaulieu, Kristine AU - Beaulieu K AUID- ORCID: 0000-0001-8926-6953 AD - Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Herlev, Denmark. AD - School of Psychology, University of Leeds, Leeds, UK. FAU - Faerch, Kristine AU - Faerch K AD - Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Herlev, Denmark. AD - Novo Nordisk A/S, Soborg, Denmark. FAU - Grunnet, Louise Groth AU - Grunnet LG AD - Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Herlev, Denmark. FAU - Quist, Jonas Salling AU - Quist JS AUID- ORCID: 0000-0001-6036-0962 AD - Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Herlev, Denmark jonas.salling.quist@regionh.dk. AD - School of Psychology, University of Leeds, Leeds, UK. AD - Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. LA - eng SI - ClinicalTrials.gov/NCT05768958 PT - Clinical Trial Protocol PT - Journal Article DEP - 20250206 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/complications MH - Female MH - Male MH - Adult MH - Middle Aged MH - Cross-Over Studies MH - Denmark MH - *Exercise/physiology MH - *Energy Intake MH - *Obesity/therapy/complications MH - Aged MH - *Overweight/therapy/complications MH - Adolescent MH - Young Adult MH - *Appetite Regulation/physiology MH - Randomized Controlled Trials as Topic MH - Time Factors MH - Appetite PMC - PMC11800291 OTO - NOTNLM OT - Diabetes Mellitus, Type 2 OT - Exercise OT - NUTRITION & DIETETICS OT - Obesity OT - Overweight OT - Randomised Controlled Trial COIS- Competing interests: LJ, NPL, MMJ, MBB, LGG and JSQ are employed by Steno Diabetes Center Copenhagen ( SDCC). SDCC is a hospital providing health services for the public health care system. SDCC is funded by the Novo Nordisk Foundation through unrestricted grants. The Novo Nordisk Foundation has no economic interests in the study. The Novo Nordisk Foundation will not have influence on (1) the study design; (2) the collection, analysis and interpretation of data; (3) the writing of the study report or any publication; and (4) the decision to submit the paper for publication. The investigators employed at SDCC will not benefit economically from conducting the study. Co-investigator MKG is employed at Novo Nordisk and will be responsible for exploratory investigations using the data collected in the TIMEX study. Due to the collaborative nature of the study, Novo Nordisk has been involved in designing the study and will be involved in analysing and interpreting data. Novo Nordisk will align with SDCC if and when data and/or biosamples from the study are used for publications. HEP and KF are now employed by Novo Nordisk. iMotions is a collaborator on the project and give advice for the use and analysis of biometric methods in the study design phase. iMotions A/S have no influence on (1) the study design; (2) the collection, analysis and interpretation of data; (3) the writing of the study report or any publication; and (4) the decision to submit the paper for publication. LGG and KF own shares in Novo Nordisk. The sponsor and principal investigator, JSQ, have no economic interest in the results of the study. All other authors have no competing interests to declare. EDAT- 2025/02/07 00:20 MHDA- 2025/02/07 00:21 PMCR- 2025/02/06 CRDT- 2025/02/06 21:13 PHST- 2025/02/07 00:21 [medline] PHST- 2025/02/07 00:20 [pubmed] PHST- 2025/02/06 21:13 [entrez] PHST- 2025/02/06 00:00 [pmc-release] AID - bmjopen-2024-092683 [pii] AID - 10.1136/bmjopen-2024-092683 [doi] PST - epublish SO - BMJ Open. 2025 Feb 6;15(2):e092683. doi: 10.1136/bmjopen-2024-092683. PMID- 39914893 OWN - NLM STAT- MEDLINE DCOM- 20250711 LR - 20250711 IS - 1872-7727 (Electronic) IS - 0720-048X (Linking) VI - 183 DP - 2025 Feb TI - A multifactorial modeling to predicting tibial stress fractures: The role of tibial anatomy in adolescents. PG - 111932 LID - S0720-048X(25)00018-X [pii] LID - 10.1016/j.ejrad.2025.111932 [doi] AB - OBJECTIVE: This study aimed to investigate the impact of tibial anatomical structure, age, sex, average weekly exercise time during adolescence (AWETA), and BMI on the risk of tibial stress fractures (SF) and to develop a predictive model using logistic regression. METHODS: We retrospectively analyzed 748 patients presenting with calf pain at our hospital from January 1, 2018, to August 31, 2023. After applying inclusion and exclusion criteria, 493 patients were categorized into the SF group (295 cases) and the control group (198 cases). Detailed patient information was collected, including height, weight, age, AWETA, history of recent prolonged exercise, and tibial measurements. Data were analyzed using appropriate statistical tests to determine between-group differences, and binary logistic regression analysis was performed to identify independent risk factors and develop a predictive model. RESULTS: Body weight, BMI, AWETA, anteroposterior tibial plateau diameter, anterior tibial bowing angle, and gender showed significant differences between the SF and control groups. Logistic regression identified BMI (OR = 7.39, 95 % CI: 1.89-28.86), AWETA (OR = 0.54, 95 % CI: 0.46-0.62), and anterior tibial bowing angle (OR = 0.44, 95 % CI: 0.33-0.58) as independent predictors of tibial SF. The model demonstrated high predictive performance, with an AUC of 0.916, sensitivity of 93.9 %, and specificity of 89.4 %. CONCLUSION: Anterior tibial bowing angle, BMI, and AWETA are strong predictors of tibial SF in young individuals. The developed predictive model provides a reliable tool for assessing tibial SF risk in clinical practice. CI - Copyright (c) 2025 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Zhao, Tieniu AU - Zhao T AD - Department of Radiology, 924th Hospital of the Joint Service Support Force of the People's Liberation Army, 1 Xinqiaoyuan Street Xiangshan District, Guilin 541002, China. FAU - Chen, Cheng AU - Chen C AD - Emei Rehabilitation and Recovery Center, Leshan, Sichuan 614200, China. FAU - Zeng, Yangdong AU - Zeng Y AD - Department of Radiology, the Affiliated Hospital of Guilin Medical University,15 Lequn Street Xiufeng District, Guilin 541004, China. FAU - Huang, Li AU - Huang L AD - Department of Radiology, 924th Hospital of the Joint Service Support Force of the People's Liberation Army, 1 Xinqiaoyuan Street Xiangshan District, Guilin 541002, China. FAU - Shi, Changbing AU - Shi C AD - Department of Radiology, 924th Hospital of the Joint Service Support Force of the People's Liberation Army, 1 Xinqiaoyuan Street Xiangshan District, Guilin 541002, China. FAU - Wang, Meifeng AU - Wang M AD - Department of Radiology, 924th Hospital of the Joint Service Support Force of the People's Liberation Army, 1 Xinqiaoyuan Street Xiangshan District, Guilin 541002, China. FAU - Liang, Jianming AU - Liang J AD - Department of Orthopaedics, 924th Hospital of the Joint Service Support Force of the People's Liberation Army, 1 Xinqiaoyuan Street Xiangshan District, Guilin 541002, China. FAU - Dai, Zheng AU - Dai Z AD - Department of Radiology, 924th Hospital of the Joint Service Support Force of the People's Liberation Army, 1 Xinqiaoyuan Street Xiangshan District, Guilin 541002, China. Electronic address: jeremy120327@163.com. FAU - Hu, Xiaofei AU - Hu X AD - Department of Nuclear Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China. Electronic address: harryzonetmmu@163.com. LA - eng PT - Journal Article DEP - 20250119 PL - Ireland TA - Eur J Radiol JT - European journal of radiology JID - 8106411 SB - IM MH - Humans MH - Male MH - Female MH - Young Adult MH - Retrospective Studies MH - Body Mass Index MH - Logistic Models MH - Adolescent MH - *Tibial Fractures/diagnostic imaging MH - *Fractures, Stress/diagnostic imaging MH - Exercise MH - Time Factors MH - *Predictive Learning Models MH - *Tibia/anatomy & histology/diagnostic imaging MH - Sensitivity and Specificity MH - Reproducibility of Results MH - Risk Factors MH - Area Under Curve MH - *Image Processing, Computer-Assisted/methods MH - Observer Variation OTO - NOTNLM OT - Anterior arch angle OT - Logistic regression OT - Stress fracture OT - Tibia COIS- Declaration of competing interest This study was supported by Guilin City Self-Financing Subject, Contract No. (20220145Z). EDAT- 2025/02/07 00:20 MHDA- 2025/02/07 00:21 CRDT- 2025/02/06 20:56 PHST- 2024/09/08 00:00 [received] PHST- 2024/12/25 00:00 [revised] PHST- 2025/01/14 00:00 [accepted] PHST- 2025/02/07 00:21 [medline] PHST- 2025/02/07 00:20 [pubmed] PHST- 2025/02/06 20:56 [entrez] AID - S0720-048X(25)00018-X [pii] AID - 10.1016/j.ejrad.2025.111932 [doi] PST - ppublish SO - Eur J Radiol. 2025 Feb;183:111932. doi: 10.1016/j.ejrad.2025.111932. Epub 2025 Jan 19. PMID- 39914378 OWN - NLM STAT- MEDLINE DCOM- 20250506 LR - 20250526 IS - 1543-5474 (Electronic) IS - 1543-3080 (Linking) VI - 22 IP - 4 DP - 2025 Apr 1 TI - Who Are We Excluding From Physical Activity Research? Examining the Potential for Exclusion Bias in Pedometer Data Processing. PG - 512-520 LID - 10.1123/jpah.2024-0503 [doi] AB - BACKGROUND: Pedometers are a useful measure of physical activity (PA) but whether systematic bias exists when using differing inclusion criterion for pedometer-derived PA data is unknown. We undertake an exploration of previously published criteria for pedometer data cleaning and examine the impact of different inclusion criteria on sample size retention and participant exclusion by key sociodemographic characteristics. METHODS: Data were drawn from a community survey in Aotearoa/New Zealand. Sociodemographic information and self-reported PA were collected via face-to-face surveys; participants were asked to wear a Yamax CW300 pedometer for 7 days. Analyses involved removing extreme outliers and determining minimum steps per day for inclusion, determining whether day 1 removal was required, examining risk of bias using different inclusion criteria, and examining convergent and concurrent validity of criteria with the lowest bias potential. RESULTS: Pedometer data were available for 895 participants. A threshold of 100 steps/day was deemed appropriate to define a valid day. All days were correlated with each other; intraclass correlation coefficients were low and did not change meaningfully with removal of the first day of data. Participant retention reduced, and bias in participant inclusion increased, with increasing stringency of data inclusion criterion applied. Evidence for convergent and concurrent validity in the 2 models with the lowest risk of exclusion bias was demonstrated. CONCLUSION: Increasing stringency in pedometer data inclusion criteria can result in significant and biased loss of sample size. Clear reporting of data cleaning methods and rationale (including consideration of potential for bias) is needed in pedometer-based PA research. FAU - Smith, Melody AU - Smith M AUID- ORCID: 0000-0002-0987-2564 AD - School of Nursing, The University of Auckland, Auckland, New Zealand. FAU - Cavadino, Alana AU - Cavadino A AUID- ORCID: 0000-0002-5709-367X AD - School of Population Health, The University of Auckland, Auckland, New Zealand. FAU - Narayanan, Anantha AU - Narayanan A AUID- ORCID: 0000-0002-1577-803X AD - School of Nursing, The University of Auckland, Auckland, New Zealand. AD - School of Sport and Recreation, Auckland University of Technology, Auckland, New Zealand. LA - eng PT - Journal Article DEP - 20250206 PL - United States TA - J Phys Act Health JT - Journal of physical activity & health JID - 101189457 SB - IM MH - Humans MH - Female MH - Male MH - *Exercise MH - Adult MH - Middle Aged MH - New Zealand MH - Bias MH - *Actigraphy/instrumentation MH - Walking MH - Young Adult MH - Aged MH - Self Report MH - Adolescent MH - Reproducibility of Results MH - *Patient Selection OTO - NOTNLM OT - data treatment OT - equity OT - measurement OT - pedometry OT - steps EDAT- 2025/02/07 00:20 MHDA- 2025/03/19 18:23 CRDT- 2025/02/06 18:32 PHST- 2024/07/25 00:00 [received] PHST- 2024/11/25 00:00 [revised] PHST- 2024/11/30 00:00 [accepted] PHST- 2025/03/19 18:23 [medline] PHST- 2025/02/07 00:20 [pubmed] PHST- 2025/02/06 18:32 [entrez] AID - 10.1123/jpah.2024-0503 [doi] PST - epublish SO - J Phys Act Health. 2025 Feb 6;22(4):512-520. doi: 10.1123/jpah.2024-0503. Print 2025 Apr 1. PMID- 39913480 OWN - NLM STAT- MEDLINE DCOM- 20250506 LR - 20261015 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 2 DP - 2025 TI - Diet quality of Chilean schoolchildren: How is it linked to adherence to dietary guidelines? PG - e0318206 LID - 10.1371/journal.pone.0318206 [doi] LID - e0318206 AB - INTRODUCTION: In Chile, the prevalence of overweight among schoolchildren over the age of 5 is approximately 50%, one of the highest in the Americas region. This is largely influenced by the presence of inadequate food environments, characterized by limited access to healthy foods and a high availability of highly processed foods (HPF). This study analyzes food consumption in Chilean schoolchildren and the association of this with the Chilean Dietary Guidelines Based on Foods (DGBF) and the HPF consumption. MATERIAL AND METHODS: The sample (1,094 schoolchildren) was obtained from the baseline of the FONDEF IT18I0016 project, in Santiago-Chile. Anthropometry and socioeconomic data were measured. Dietary intake was assessed using a validated semi-quantitative frequency survey featuring images of food groups aligned with DGBF, as well as HPF. All data were collected by trained professional nutritionists. Associations between dependent and independent variables, and potential confounding factors were calculated using logistic regression models with stepwise backward/forward. A p < 0.05 was accepted as significant, using Stata 16.0. RESULTS: Most of the students (54.1%) were with malnutrition by excess and 20.0% exhibited abdominal obesity. Twenty percent of the students met the recommended intake for DGBF (fruits, vegetables, fish, milk and dairy products, legumes, water) and less than 5% did not consume any HPF. Consuming some sub-groups of HPF in moderate quantities (either no consumption or occasional consumption) increases the likelihood of meeting DGBF: candies and sweets (OR: 0.72; p = 0.04), pies with or without filling (OR: 0.63; p = 0.01), and salted snacks (OR: 0.67; p = 0.02). CONCLUSION: Our results contribute to reaffirm the need to enhance healthy food consumption among schoolchildren and to discourage the intake of HPF, particularly focusing on specific sub-groups of HPF that may increase the risk of displacing the consumption of food groups recommended by the DGBF. CI - Copyright: (c) 2025 Pinheiro Fernandes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Pinheiro Fernandes, Anna Christina AU - Pinheiro Fernandes AC AUID- ORCID: 0000-0002-5188-2619 AD - Carrera de Nutricion y Dietetica, Facultad de Medicina Clinica Alemana, Universidad del Desarrollo, Las Condes, Santiago, Chile. FAU - Araneda Flores, Jacqueline AU - Araneda Flores J AD - Faculty of Health and Food Sciences, University of Bio-Bio, Chillan, Chile. FAU - Quintiliano Scarpelli Dourado, Daiana AU - Quintiliano Scarpelli Dourado D AUID- ORCID: 0000-0003-4317-4601 AD - Carrera de Nutricion y Dietetica, Facultad de Medicina Clinica Alemana, Universidad del Desarrollo, Las Condes, Santiago, Chile. FAU - Pizarro Quevedo, Tito AU - Pizarro Quevedo T AD - Faculty of Medical Sciences, University of Santiago de Chile, Santiago, Chile. FAU - Marques de Oliveira, Maria Rita AU - Marques de Oliveira MR AD - Institute of Biosciences, Sao Paulo State University (UNESP), Rua Prof. Dr. Antonio Celso Wagner Zanin, Botucatu, SP, Brazil. LA - eng PT - Journal Article DEP - 20250206 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Chile/epidemiology MH - Child MH - Female MH - Male MH - *Nutrition Policy MH - *Diet MH - Feeding Behavior PMC - PMC11801533 COIS- NO authors have competing interests EDAT- 2025/02/06 23:00 MHDA- 2025/02/06 23:01 PMCR- 2025/02/06 CRDT- 2025/02/06 13:54 PHST- 2024/10/06 00:00 [received] PHST- 2025/01/10 00:00 [accepted] PHST- 2025/02/06 23:01 [medline] PHST- 2025/02/06 23:00 [pubmed] PHST- 2025/02/06 13:54 [entrez] PHST- 2025/02/06 00:00 [pmc-release] AID - PONE-D-24-44093 [pii] AID - 10.1371/journal.pone.0318206 [doi] PST - epublish SO - PLoS One. 2025 Feb 6;20(2):e0318206. doi: 10.1371/journal.pone.0318206. eCollection 2025. PMID- 39912070 OWN - NLM STAT- MEDLINE DCOM- 20250206 LR - 20250526 IS - 2005-4408 (Electronic) IS - 2005-291X (Print) IS - 2005-291X (Linking) VI - 17 IP - 1 DP - 2025 Feb TI - Unveiling and Validating a Modified Method to Assess Cervical Sagittal Alignment as an Effective Substitute for Conventional C2-7 Cobb Angle. PG - 130-137 LID - 10.4055/cios24186 [doi] AB - BACKGROUND: Developing and validating a modified parameter, the SYS-G angle (the angle between the lower endplate of the C2 and the upper endplate of C7 vertebrae), as a feasible substitute for the C2-C7 Cobb method in assessing cervical sagittal alignment and exploring its reference range through a large-scale retrospective study. METHODS: The visibility of the C6, C7 upper, and C7 lower endplates was graded and compared. Baseline data such as height, weight, body mass index (BMI), age, and sex were analyzed for their impact on the visibility of the C7 lower endplate. Values of C2-6 Cobb angle, SYS-G angle, and C2-7 Cobb angle were measured. The intra- and interobserver reliability, differences, and efficacy of evaluation on cervical lordosis of the parameters were compared, and the correlations among the parameters were analyzed. Furthermore, reference ranges for the SYS-G angle were established based on lateral cervical spine x-rays of 825 asymptomatic Chinese adults across different age groups and sexes. RESULTS: The visibility of the C7 lower endplates was significantly reduced compared to the C6 lower and C7 upper endplates. Age, weight, BMI, and male sex were identified as factors negatively influencing the visibility of the C7 lower endplate. Both intraobserver and interobserver reliability demonstrated excellence for all tested parameters. The linear regression model unveiled a stronger association of the SYS-G angle with the C2-7 Cobb angle compared to the C2-6 Cobb angle. Furthermore, the SYS-G angle exhibited excellent efficacy in evaluating cervical lordosis. Age displayed a positive correlation with the SYS-G angle, and across every age bracket from 20 to 69 years, men exhibited a higher mean SYS-G angle compared to women. CONCLUSIONS: The visibility of the C7 lower endplate diminishes with increasing age, weight, BMI, and male sex. In cases where the C7 lower endplate is unclear, the SYS-G angle emerges as a reliable method for estimating cervical sagittal morphology. Reference ranges for the SYS-G angle were established across various age groups and sexes among asymptomatic Chinese adults, offering a valuable resource to guide therapeutic interventions for cervical spine disorders and deformities. CI - Copyright (c) 2025 by The Korean Orthopaedic Association. FAU - Li, Wenpeng AU - Li W AUID- ORCID: 0000-0002-8158-6490 AD - Department of Neurosurgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. AD - Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Wang, Qiwei AU - Wang Q AUID- ORCID: 0009-0003-0401-8486 AD - Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Zhao, Qiancheng AU - Zhao Q AUID- ORCID: 0000-0003-4791-4865 AD - Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Zeng, Ziliang AU - Zeng Z AUID- ORCID: 0000-0002-0095-8396 AD - Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Hu, Xumin AU - Hu X AUID- ORCID: 0000-0002-8505-9970 AD - Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Lv, Xin AU - Lv X AUID- ORCID: 0009-0004-1511-3814 AD - Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Gao, Liangbin AU - Gao L AUID- ORCID: 0000-0002-9333-7336 AD - Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20250114 PL - Korea (South) TA - Clin Orthop Surg JT - Clinics in orthopedic surgery JID - 101505087 SB - IM MH - Humans MH - Male MH - *Cervical Vertebrae/diagnostic imaging/anatomy & histology MH - Female MH - Adult MH - Middle Aged MH - Retrospective Studies MH - Aged MH - Young Adult MH - *Lordosis/diagnostic imaging MH - Reproducibility of Results MH - Adolescent MH - Reference Values MH - Radiography MH - Aged, 80 and over PMC - PMC11791497 OTO - NOTNLM OT - Cervical vertebra OT - Spinal curvatures OT - X-rays COIS- CONFLICT OF INTEREST: No potential conflict of interest relevant to this article was reported. EDAT- 2025/02/06 06:20 MHDA- 2025/02/06 06:21 PMCR- 2025/02/01 CRDT- 2025/02/06 04:38 PHST- 2024/05/03 00:00 [received] PHST- 2024/10/30 00:00 [revised] PHST- 2024/10/30 00:00 [accepted] PHST- 2025/02/06 06:21 [medline] PHST- 2025/02/06 06:20 [pubmed] PHST- 2025/02/06 04:38 [entrez] PHST- 2025/02/01 00:00 [pmc-release] AID - 10.4055/cios24186 [doi] PST - ppublish SO - Clin Orthop Surg. 2025 Feb;17(1):130-137. doi: 10.4055/cios24186. Epub 2025 Jan 14. PMID- 39911881 OWN - NLM STAT- MEDLINE DCOM- 20250714 LR - 20260923 IS - 2046-1402 (Electronic) IS - 2046-1402 (Linking) VI - 13 DP - 2024 TI - Influencing factors of health-related quality-of-life perceived by both children/adolescents patients with type-1 diabetes mellitus and their parents: A North-African study. PG - 429 LID - 10.12688/f1000research.148074.2 [doi] LID - 429 AB - AIM: To determine the influencing factors of health-related quality-of-life (HRQoL) perceived by North-African children/adolescents with type-1 diabetes-mellitus (T1DM) and their parents. METHODS: It was a cross sectional study conducted in Tunisia. A total of 116 patients ( ie ; 43 children and 73 adolescents) and their parents were included. The Arabic validated version of the Pediatric Generic Core Quality-of-Life Inventory 4.0-Scale (PedsQL4.0) was used to evaluate the HRQoL of children/adolescents as perceived by patients and parents. The dependent data were the patients' self-report and the parents' proxy-report of the PedsQL4.0 total scores, and the independent data were the patients and parents characteristics. RESULTS: Patients' PedsQL4.0 total score was influenced significantly by siblings in the family > 2; lipodystrophy, and glycosylated hemoglobin (HbA1C). The combination of these factors explained 34.84% of the PedsQL4.0 total score variability. Parents' PedsQL4.0 total score was influenced significantly by lipodystrophy, siblings; body mass index (BMI), hypoglycemia episodes, and HbA1C. The combination of these factors explained 56.92% of the PedsQL4.0 total score variability. CONCLUSION: T1DM patients self-reported HRQoL was influenced by siblings in the family > 2; lipodystrophy, and HbA1C. The parents' proxy-report HRQoL was influenced by lipodystrophy, siblings, BMI, hypoglycemia episodes, and HbA1C. CI - Copyright: (c) 2025 Ben Abdesselem I et al. FAU - Ben Abdesselem, Imen AU - Ben Abdesselem I AUID- ORCID: 0000-0002-8464-0720 AD - Research Laboratory "Heart failure" (LR12SP09), University of Sousse, Sousse, 4002, Tunisia. AD - Laboratory of Physiology, Faculty of Medicine of Sousse, University of Sousse, Sousse, 4002, Tunisia. AD - Faculty of Medicine of Sousse, University of Sousse, Sousse, 4002, Tunisia. AD - Department of Physiology and Functional Explorations, Hospital Farhat HACHED, Sousse, 4002, Tunisia. FAU - Kebeili, Raoudha AU - Kebeili R AD - Faculty of Medicine of Sousse, University of Sousse, Sousse, 4002, Tunisia. AD - Pediatrics, Hospital Farhat HACHED, Sousse, 4002, Tunisia. FAU - Derbel, Khansa AU - Derbel K AD - Research Laboratory "Heart failure" (LR12SP09), University of Sousse, Sousse, 4002, Tunisia. AD - Faculty of Medicine of Sousse, University of Sousse, Sousse, 4002, Tunisia. AD - Department of Physiology and Functional Explorations, Hospital Farhat HACHED, Sousse, 4002, Tunisia. FAU - Ben Said, Hichem AU - Ben Said H AD - Pediatrics, Hospital Farhat HACHED, Sousse, 4002, Tunisia. FAU - Boughamoura, Lamia AU - Boughamoura L AD - Faculty of Medicine of Sousse, University of Sousse, Sousse, 4002, Tunisia. AD - Pediatrics, Hospital Farhat HACHED, Sousse, 4002, Tunisia. FAU - Bouguila, Jihene AU - Bouguila J AD - Research Laboratory "Heart failure" (LR12SP09), University of Sousse, Sousse, 4002, Tunisia. AD - Faculty of Medicine of Sousse, University of Sousse, Sousse, 4002, Tunisia. AD - Pediatrics, Hospital Farhat HACHED, Sousse, 4002, Tunisia. FAU - Ben Saad, Helmi AU - Ben Saad H AUID- ORCID: 0000-0002-7477-2965 AD - Research Laboratory "Heart failure" (LR12SP09), University of Sousse, Sousse, 4002, Tunisia. AD - Laboratory of Physiology, Faculty of Medicine of Sousse, University of Sousse, Sousse, 4002, Tunisia. AD - Faculty of Medicine of Sousse, University of Sousse, Sousse, 4002, Tunisia. AD - Department of Physiology and Functional Explorations, Hospital Farhat HACHED, Sousse, 4002, Tunisia. LA - eng PT - Journal Article DEP - 20250117 PL - England TA - F1000Res JT - F1000Research JID - 101594320 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/psychology MH - *Quality of Life MH - Child MH - Adolescent MH - Female MH - Male MH - *Parents/psychology MH - Cross-Sectional Studies MH - Adult MH - Tunisia MH - Surveys and Questionnaires MH - Self Report PMC - PMC11795355 OTO - NOTNLM OT - Adolescent OT - Child OT - Diabetes mellitus type 1 OT - HRQoL OT - North Africa OT - Parents COIS- No competing interests were disclosed. EDAT- 2025/02/06 06:20 MHDA- 2025/02/06 06:21 PMCR- 2025/01/17 CRDT- 2025/02/06 04:36 PHST- 2025/01/07 00:00 [accepted] PHST- 2025/02/06 06:20 [pubmed] PHST- 2025/02/06 06:21 [medline] PHST- 2025/02/06 04:36 [entrez] PHST- 2025/01/17 00:00 [pmc-release] AID - 10.12688/f1000research.148074.2 [doi] PST - epublish SO - F1000Res. 2025 Jan 17;13:429. doi: 10.12688/f1000research.148074.2. eCollection 2024. PMID- 39910982 OWN - NLM STAT- MEDLINE DCOM- 20250505 LR - 20250526 IS - 1365-2214 (Electronic) IS - 0305-1862 (Print) IS - 0305-1862 (Linking) VI - 51 IP - 2 DP - 2025 Mar TI - Exploring the Extent and Nature of Disordered Eating Among Canadian Adolescents and Young Adults With Spina Bifida and Hydrocephalus. PG - e70046 LID - 10.1111/cch.70046 [doi] LID - e70046 AB - BACKGROUND: Adolescents and young adults (AYA) with spina bifida and/or hydrocephalus (SBH) are at a higher risk for disordered eating, poor body image and body dissatisfaction. Regrettably, there is limited research on the eating patterns and behaviours of AYA with SBH, as well as their body image perceptions. OBJECTIVES: The purpose of this study was to explore the nature of disordered eating behaviours among AYA with SBH and their perceptions surrounding their body image. This study represents the first investigation of its kind conducted within a Canadian population. It fills a literature gap regarding the understanding of disordered eating behaviours and body image perceptions among young individuals with SBH in Canada. METHODS: The study comprised a self-report, cross-sectional online survey of AYA with SBH across Canada. The survey comprised validated brief measures to evaluate eating behaviours, disordered eating and body esteem. AYA aged 12-26 years with any type of SBH were eligible to participate. RESULTS: Twenty-four participants were recruited. Results indicated that AYA with SBH may face an elevated risk for eating disorders/disordered eating compared to their typically developing peers, due to a myriad of reasons not typically experienced in the general population such as bowel and bladder management, mobility issues and eating aversions. Findings also indicated that some AYA with SBH may have poor body image and that it is possible that this is not discussed in SBH clinics. CONCLUSION: Our work underscores the urgency for further research that focuses on assessing eating disorders/disordered eating behaviours in AYA with SBH. CI - (c) 2025 The Author(s). Child: Care, Health and Development published by John Wiley & Sons Ltd. FAU - Bonder, Revi AU - Bonder R AUID- ORCID: 0000-0002-9711-851X AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada. FAU - Beaudoin, Shauna AU - Beaudoin S AD - Programs & Information, Hydrocephalus Canada, Toronto, Ontario, Canada. FAU - Chen, Lorry AU - Chen L AD - Child Development Program, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada. FAU - Church, Paige AU - Church P AUID- ORCID: 0000-0001-5844-3953 AD - Divison of Neontology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. FAU - Hooper, Marie AU - Hooper M AD - Flourish Health Services, Toronto, Ontario, Canada. FAU - Thorne, Melissa AU - Thorne M AD - Spina Bifida and Spinal Cord Injury Clinic, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada. FAU - Toulany, Alene AU - Toulany A AD - Division of Adolescent Medicine, Hospital for Sick Children, Toronto, Ontario, Canada. FAU - McPherson, Amy C AU - McPherson AC AUID- ORCID: 0000-0003-4186-3200 AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada. AD - SickKids Research Institute, University of Toronto, Toronto, Ontario, Canada. LA - eng GR - Spina Bifida and Hydrocephalus Association of Canada/ PT - Journal Article PL - England TA - Child Care Health Dev JT - Child: care, health and development JID - 7602632 SB - IM MH - Humans MH - Adolescent MH - *Spinal Dysraphism/psychology/complications/epidemiology MH - *Feeding and Eating Disorders/epidemiology/psychology/etiology MH - Female MH - Cross-Sectional Studies MH - Male MH - Canada/epidemiology MH - Young Adult MH - Adult MH - *Body Image/psychology MH - *Hydrocephalus/psychology/complications/epidemiology MH - Child MH - Feeding Behavior/psychology MH - Self Report PMC - PMC11799823 OTO - NOTNLM OT - body image OT - disordered eating OT - eating disorders OT - youth with disabilities COIS- The authors declare no conflicts of interest. EDAT- 2025/02/06 06:20 MHDA- 2025/02/06 06:21 PMCR- 2025/02/06 CRDT- 2025/02/06 03:13 PHST- 2024/12/17 00:00 [revised] PHST- 2024/03/07 00:00 [received] PHST- 2025/01/22 00:00 [accepted] PHST- 2025/02/06 06:21 [medline] PHST- 2025/02/06 06:20 [pubmed] PHST- 2025/02/06 03:13 [entrez] PHST- 2025/02/06 00:00 [pmc-release] AID - CCH70046 [pii] AID - 10.1111/cch.70046 [doi] PST - ppublish SO - Child Care Health Dev. 2025 Mar;51(2):e70046. doi: 10.1111/cch.70046. PMID- 39910699 OWN - NLM STAT- MEDLINE DCOM- 20250206 LR - 20250526 IS - 1365-277X (Electronic) IS - 0952-3871 (Linking) VI - 38 IP - 1 DP - 2025 Feb TI - Development and Validation of Healthy and Unhealthy Plant-Based Diet Propensity Scores in European Children, Adolescents and Adults From the I.Family Study. PG - e70021 LID - 10.1111/jhn.70021 [doi] AB - INTRODUCTION: Plant-based dietary patterns may reduce the risk of chronic diseases, but their benefits and risks in younger populations remain unclear due to variations in diet quality and nutrient adequacy. Robust tools to assess adherence to these patterns are essential. The aim of this study was to develop and validate three plant-based diet propensity (PBDP) scores - overall, healthy and unhealthy - to capture plant-based dietary patterns and assess their associations with nutrient intakes and health indicators in children, adolescents and adults. METHODS: This cross-sectional study of children, adolescents and adults used data from the I.Family study (n = 15,780 participants) from eight European countries. Dietary intake was assessed using a food frequency questionnaire. The overall PBDP score was constructed by categorising all plant-based food groups as positive and animal-based food groups as negative. The healthy PBDP emphasised healthy plant-based food groups, whereas the unhealthy PBDP emphasised less healthy plant-based food groups. Validity was assessed through correlations with nutrient intakes and comparison across demographic groups. Associations with health indicators were also analysed. RESULTS: PBDP scores showed expected associations with nutrient intakes. Higher overall and healthy PBDP scores were observed in females, adults, individuals with higher parental educational levels and those from Belgium and Spain. The healthy PBDP score was associated with higher HDL cholesterol, improved bone stiffness and lower triglycerides. The unhealthy PBDP score was associated with lower HDL cholesterol in adults, but not in children or adolescents. CONCLUSION: PBDP scores describe plant-based dietary patterns across demographic groups and are valid and reliable in adults. The findings highlight challenges in assessing dietary patterns in children and adolescents. Future research should address these challenges to enhance the validity of PBDP scores in younger populations and further explore their potential in guiding dietary recommendations across all age groups. CI - (c) 2025 The British Dietetic Association Ltd. FAU - Masip, Guiomar AU - Masip G AD - Growth, Exercise, Nutrition and Development (GENUD) Research Group, Faculty of Health Sciences, Instituto Agroalimentario de Aragon (IA2), Instituto de Investigacion Sanitaria Aragon (IIS Aragon), Universidad de Zaragoza, Zaragoza, Spain. AD - Finnish Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland. FAU - Goerdten, Jantje AU - Goerdten J AD - Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. FAU - Asif, Tooba AU - Asif T AD - Department of Public Health and Primary Care (GE39), Ghent University Unit Public Health Nutrition, Ghent, Belgium. FAU - Hebestreit, Antje AU - Hebestreit A AD - Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. FAU - Hunsberger, Monica AU - Hunsberger M AD - School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden. FAU - Lissner, Lauren AU - Lissner L AD - School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden. FAU - Molnar, Denes AU - Molnar D AD - Department of Paediatrics, Medical School, University of Pecs, Pecs, Hungary. FAU - Pala, Valeria AU - Pala V AD - Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. FAU - Russo, Paola AU - Russo P AD - Institute of Food Sciences, National Research Council, Avellino, Italy. FAU - Tornaritis, Michael AU - Tornaritis M AD - Research and Education Institute for Child Health, Strovolos, Cyprus. FAU - Veidebaum, Toomas AU - Veidebaum T AUID- ORCID: 0000-0001-7659-8924 AD - Department of Chronic Diseases, National Institute for Health Development, Tallinn, Estonia. FAU - Wolters, Maike AU - Wolters M AD - Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. FAU - Moreno, Luis A AU - Moreno LA AUID- ORCID: 0000-0003-0454-653X AD - Growth, Exercise, Nutrition and Development (GENUD) Research Group, Faculty of Health Sciences, Instituto Agroalimentario de Aragon (IA2), Instituto de Investigacion Sanitaria Aragon (IIS Aragon), Universidad de Zaragoza, Zaragoza, Spain. AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. FAU - Bogl, Leonie H AU - Bogl LH AD - Finnish Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland. AD - Department of Nutrition and Dietetics, Faculty of Health Professions, Bern University of Applied Sciences, Bern, Switzerland. LA - eng GR - The study was funded by the European Commission within the Seventh RTD Framework Programme Contract No. 266044 (KBBE 2010-14), the 'Ayudas para contratos Juan de la Cierva' funded for MCIU/AEI/10.13039/50110001103, the European Union 'NextGeneration/PRTR' grant reference number: JDC2022-048656-I and by a grant from the Ekhagastiftelsen (Ekhaga foundation) under the project number 2021-78./ PT - Journal Article PT - Validation Study PL - England TA - J Hum Nutr Diet JT - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JID - 8904840 SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - Cross-Sectional Studies MH - Child MH - Adult MH - Europe MH - *Diet, Healthy/statistics & numerical data MH - *Diet, Vegetarian/statistics & numerical data MH - Young Adult MH - Diet Surveys MH - Middle Aged MH - *Propensity Score MH - Reproducibility of Results MH - Surveys and Questionnaires MH - Nutrition Assessment MH - Diet, Plant-Based OTO - NOTNLM OT - diet quality OT - diet score OT - food frequency questionnaire OT - nutrient intake OT - plant-based dietary pattern EDAT- 2025/02/06 00:20 MHDA- 2025/02/06 06:20 CRDT- 2025/02/05 23:55 PHST- 2025/01/20 00:00 [revised] PHST- 2024/07/31 00:00 [received] PHST- 2025/01/21 00:00 [accepted] PHST- 2025/02/06 06:20 [medline] PHST- 2025/02/06 00:20 [pubmed] PHST- 2025/02/05 23:55 [entrez] AID - 10.1111/jhn.70021 [doi] PST - ppublish SO - J Hum Nutr Diet. 2025 Feb;38(1):e70021. doi: 10.1111/jhn.70021. PMID- 39910488 OWN - NLM STAT- MEDLINE DCOM- 20250206 LR - 20260923 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Feb 5 TI - Predictors of depression among Chinese college students: a machine learning approach. PG - 470 LID - 10.1186/s12889-025-21632-8 [doi] LID - 470 AB - BACKGROUND: Depression is highly prevalent among college students, posing a significant public health challenge. Identifying key predictors of depression is essential for developing effective interventions. This study aimed to analyze potential depression risk factors among Chinese college students using the Random Forest Algorithm (RFA) and to explore gender differences in risk patterns. METHODS: A cross-sectional study was conducted with 10,043 undergraduate students from Guizhou Normal University. Thirty-three variables were analyzed using RFA. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale (CES-D), with a score of >/= 16 indicating depression risk. The variables included sociodemographic characteristics, physical and psychological health indicators, behavioral and lifestyle factors, socioeconomic conditions, and family mental health history. RESULTS: The RFA identified several factors associated with depression risk, with suicidal ideation, anxiety, and sleep quality exhibiting the strongest associations. Other significant predictors included academic stress, BMI, vital capacity, psychological resilience, physical fitness test scores, major satisfaction, and social network use. The model achieved an accuracy of 87.5% and an AUC of 0.927. Gender-stratified analysis suggested different patterns: physical fitness indicators showed stronger associations with depression risk among male students, while BMI was more strongly associated with depression risk among female students. CONCLUSIONS: This cross-sectional study identified factors associated with depression risk among Chinese college students, with psychological factors showing the strongest associations. Gender-specific patterns were observed, suggesting the importance of considering gender differences when developing mental health interventions. However, longitudinal studies are required to establish causal relationships and validate these findings through intervention trials. CI - (c) 2025. The Author(s). FAU - Luo, Lin AU - Luo L AD - School of Physical Education, Guizhou Normal University, Guiyang, 550075, China. 460022831@gznu.edu.cn. FAU - Yuan, Junfeng AU - Yuan J AD - School of Physical Education, Guizhou Normal University, Guiyang, 550075, China. FAU - Wu, Chenghan AU - Wu C AD - Guizhou Center for Disease Control and Prevention, Guiyang, 550001, China. FAU - Wang, Yanling AU - Wang Y AD - School of Physical Education, Guizhou Normal University, Guiyang, 550075, China. FAU - Zhu, Rui AU - Zhu R AD - School of Physical Education, Guizhou Normal University, Guiyang, 550075, China. FAU - Xu, Huilin AU - Xu H AD - School of Physical Education, Guizhou Normal University, Guiyang, 550075, China. FAU - Zhang, Luqin AU - Zhang L AD - School of Physical Education, Guizhou Normal University, Guiyang, 550075, China. FAU - Zhang, Zhongge AU - Zhang Z AD - School of Physical Education, Guizhou Normal University, Guiyang, 550075, China. LA - eng GR - 72364006/National Natural Science Foundation of China/ PT - Journal Article DEP - 20250205 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - Male MH - Cross-Sectional Studies MH - *Students/psychology/statistics & numerical data MH - Universities MH - *Depression/epidemiology MH - China/epidemiology MH - Young Adult MH - *Machine Learning MH - Risk Factors MH - Adult MH - Adolescent MH - Sex Factors PMC - PMC11800555 OTO - NOTNLM OT - College student depression OT - Gender differences OT - Machine learning OT - Predictors OT - Random forest algorithm COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki, and the research protocol was approved by the Academic Ethics Committee of Guizhou Normal University (Approval No. 20230300005). Informed consent was obtained from each participant, ensuring they were fully aware of the study's purpose and their rights. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/02/06 00:20 MHDA- 2025/02/06 06:20 PMCR- 2025/02/05 CRDT- 2025/02/05 23:45 PHST- 2024/07/18 00:00 [received] PHST- 2025/01/24 00:00 [accepted] PHST- 2025/02/06 06:20 [medline] PHST- 2025/02/06 00:20 [pubmed] PHST- 2025/02/05 23:45 [entrez] PHST- 2025/02/05 00:00 [pmc-release] AID - 10.1186/s12889-025-21632-8 [pii] AID - 21632 [pii] AID - 10.1186/s12889-025-21632-8 [doi] PST - epublish SO - BMC Public Health. 2025 Feb 5;25(1):470. doi: 10.1186/s12889-025-21632-8. PMID- 39909936 OWN - NLM STAT- MEDLINE DCOM- 20250205 LR - 20250624 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 184 IP - 2 DP - 2025 Feb 6 TI - Dietary glycemic index and load during pregnancy and offspring behavioral outcomes: exploring sex differences. PG - 178 LID - 10.1007/s00431-025-06005-y [doi] LID - 178 AB - Given the importance of carbohydrates during pregnancy and the limited evidence on the impact of its excessive intake on offspring neurodevelopment, this study aimed to assess the associations between maternal glycemic index (GI) and glycemic load (GL) during early and late pregnancy and behavior problems in 4-year-old children, considering potential sex-related differences in susceptibility to maternal diet. This observational study included 188 mother-child pairs from the ECLIPSES study. GI and GL were estimated from a validated food frequency questionnaire. Offspring behavior was assessed using the Child Behavior Checklist 1.5-5. Multivariable linear and logistic regression analyses were employed to assess the association between GI, GL, and child behavior. Children of mothers in the highest tertile of GL during the first trimester of pregnancy showed elevated scores of both internalizing (beta = 5.77; 95% CI, 2.28-9.26) and externalizing (beta = 3.95; 95% CI, 0.70-7.19) problems, including anxiety and depression problems, withdrawn, attention problems, aggressive behavior, and attention-deficit/hyperactivity problems, as well as total (beta = 5.24; 95% CI, 1.71-8.77) and autism spectrum problems (beta = 3.30; 95% CI, 1.11-5.50). Similarly, higher odd ratios were observed for internalizing (OR = 2.37; 95% CI, 1.09-5.18), externalizing (OR = 3.46; 95% CI, 1.49-8.00), and total problems (OR = 3.83; 95% CI, 1.68-8.71). These associations were more pronounced in girls. No associations were observed during the third trimester. Regarding GI, no associations were found for the evaluated outcomes in any of the trimesters. CONCLUSION: These findings indicated that elevated maternal GL during the early pregnancy, but not later stages, was associated with adverse behavioral outcomes in offspring. TRIAL REGISTRATION: EUCTR-2012-005480-28, NCT03196882. WHAT IS KNOWN: * Carbohydrate intake is important during pregnancy as glucose is the main energy source for an optimal fetal brain development. * Elevated prenatal glycemic index and glycemic load have been associated with adverse offspring outcomes but their impact on behavioral development remains insufficiently explored. WHAT IS NEW: * A high maternal glycemic load during pregnancy may increase the risk of behavioral impairments in preschool-aged offspring. * Female offspring may be more vulnerable to behavioral disturbances to elevated maternal glycemic load during gestation. CI - (c) 2025. The Author(s). FAU - Cendra-Duarte, Esther AU - Cendra-Duarte E AUID- ORCID: 0000-0001-8593-9401 AD - Universitat Rovira i Virgili, Unitat de Salut Publica i Epidemiologia Nutricional, Nutrition and Mental Health (NUTRISAM) Research Group, Reus, Spain. AD - Collaborative Group On Lifestyles, Nutrition, and Tobacco (CENIT), Institut d'Investigacio en Atencio Primaria IDIAP Jordi Gol, Institut Catala de La Salut (ICS), Reus, Spain. FAU - Canals, Josefa AU - Canals J AUID- ORCID: 0000-0002-6209-9558 AD - Universitat Rovira i Virgili, Unitat de Salut Publica i Epidemiologia Nutricional, Nutrition and Mental Health (NUTRISAM) Research Group, Reus, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Tarragona, Spain. AD - Universitat Rovira i Virgili, Centre de Recerca en Avaluacio i Mesura de La Conducta (CRAMC), Department of Psychology, Tarragona, Spain. FAU - Becerra-Tomas, Nerea AU - Becerra-Tomas N AUID- ORCID: 0000-0002-4429-6507 AD - Universitat Rovira i Virgili, Unitat de Salut Publica i Epidemiologia Nutricional, Nutrition and Mental Health (NUTRISAM) Research Group, Reus, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Tarragona, Spain. FAU - Mateu-Fabregat, Javier AU - Mateu-Fabregat J AUID- ORCID: 0009-0002-1628-0118 AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Tarragona, Spain. AD - Universitat Rovira i Virgili, Nutrition and Metabolic Health Research Group, Department of Biochemistry and Biotechnology, Reus, Spain. AD - Center of Environmental, Food and Toxicological Technology (TecnATox), Rovira i Virgili University, Reus, Spain. FAU - Bullo, Monica AU - Bullo M AUID- ORCID: 0000-0002-0218-7046 AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Tarragona, Spain. AD - Universitat Rovira i Virgili, Nutrition and Metabolic Health Research Group, Department of Biochemistry and Biotechnology, Reus, Spain. AD - Center of Environmental, Food and Toxicological Technology (TecnATox), Rovira i Virgili University, Reus, Spain. AD - CIBER Physiology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, Madrid, Spain. FAU - Arija, Victoria AU - Arija V AUID- ORCID: 0000-0002-1758-0975 AD - Universitat Rovira i Virgili, Unitat de Salut Publica i Epidemiologia Nutricional, Nutrition and Mental Health (NUTRISAM) Research Group, Reus, Spain. victoria.arija@urv.cat. AD - Collaborative Group On Lifestyles, Nutrition, and Tobacco (CENIT), Institut d'Investigacio en Atencio Primaria IDIAP Jordi Gol, Institut Catala de La Salut (ICS), Reus, Spain. victoria.arija@urv.cat. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Tarragona, Spain. victoria.arija@urv.cat. LA - eng SI - ClinicalTrials.gov/NCT03196882 PT - Journal Article PT - Observational Study DEP - 20250206 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Glycemic Index MH - *Glycemic Load MH - Male MH - Child, Preschool MH - *Prenatal Exposure Delayed Effects/epidemiology MH - Adult MH - Sex Factors MH - *Child Behavior Disorders/etiology/epidemiology MH - *Child Behavior PMC - PMC11799018 OTO - NOTNLM OT - Behavioral problems OT - Child OT - Child development OT - Pregnancy OT - Pregnancy nutrition COIS- Declarations. Ethics approval: The ECLIPSES study was conducted under the Declaration of Helsinki. Approval for all procedures was granted by the Clinical Research Ethics Committee of the Jordi Gol University Institute for Primary Care Research (IDIAPJGol) and the Pere Virgili Health Research Institute (IISPV). Consent to participate: All participants signed an informed consent form. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/02/06 00:20 MHDA- 2025/02/06 00:21 PMCR- 2025/02/06 CRDT- 2025/02/05 23:15 PHST- 2024/09/23 00:00 [received] PHST- 2025/01/24 00:00 [accepted] PHST- 2025/01/20 00:00 [revised] PHST- 2025/02/06 00:21 [medline] PHST- 2025/02/06 00:20 [pubmed] PHST- 2025/02/05 23:15 [entrez] PHST- 2025/02/06 00:00 [pmc-release] AID - 10.1007/s00431-025-06005-y [pii] AID - 6005 [pii] AID - 10.1007/s00431-025-06005-y [doi] PST - epublish SO - Eur J Pediatr. 2025 Feb 6;184(2):178. doi: 10.1007/s00431-025-06005-y. PMID- 39908548 OWN - NLM STAT- MEDLINE DCOM- 20250205 LR - 20260921 IS - 2369-1999 (Electronic) IS - 2369-1999 (Linking) VI - 11 DP - 2025 Feb 5 TI - The Effect of Nutritional Mobile Apps on Populations With Cancer: Systematic Review. PG - e50662 LID - 10.2196/50662 [doi] LID - e50662 AB - BACKGROUND: Limited access to nutrition support among populations with cancer is a major barrier to sustainable and quality cancer care. Increasing use of mobile health in health care has raised concerns about its validity and health impacts. OBJECTIVE: This systematic review aimed to determine the effectiveness of commercial or cancer-specific nutritional mobile apps among people living with cancer. METHODS: A systematic search of the CENTRAL, Embase, PubMed (MEDLINE), and Scopus databases was carried out in May 2024. All types of intervention studies were included, except observational studies, gray literature, and reference lists of key systematic reviews. Studies were eligible for inclusion if they involved (1) patients with or survivors of cancer and (2) nutrition-related mobile apps. Studies were excluded if the nutrition intervention was not delivered via mobile app or the app intervention was accompanied by dietary counseling. The review process was conducted based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The Risk of Bias 2 and Risk of Bias in Nonrandomized Studies tools were used to assess the study quality. The Cochrane Review Manager (version 5.4) software was used to synthesize the results of the bias assessment. RESULTS: A total of 13 interventions were included, comprising 783 adults or teenagers with cancer. Most studies focused on breast cancer (6/13, 46%), overweight (6/13, 46%), and survivors (9/13, 69%). Data on anthropometry and body composition (7/13, 54%; 387 participants), nutritional status (3/13, 23%; 249 participants), dietary intake (7/13, 54%; 352 participants), and quality of life (6/13, 46%; 384 participants) were gathered. Experimental groups were more likely to report significant improvements in body weight or composition, dietary compliance, nutritional status, and quality of life than control groups. CONCLUSIONS: Although mobile app platforms are used to deliver nutrition interventions, the evidence for long-term efficacy, particularly in populations with cancer, remains elusive. More robust randomized controlled trials with larger sample sizes, as well as more homogeneous population characteristics and outcome measures, are warranted. TRIAL REGISTRATION: PROSPERO CRD42023330575; https://tinyurl.com/55v56yaj. CI - (c)Krystal Lu Shin Ng, Murallitharan Munisamy, Joanne Bee Yin Lim, Mustafa Alshagga. Originally published in JMIR Cancer (https://cancer.jmir.org), 05.02.2025. FAU - Ng, Krystal Lu Shin AU - Ng KLS AUID- ORCID: 0000-0002-1573-8409 AD - Division of Biomedical Sciences, Faculty of Science and Engineering, University of Nottingham Malaysia Campus, Semenyih, Malaysia. FAU - Munisamy, Murallitharan AU - Munisamy M AUID- ORCID: 0000-0002-1586-8529 AD - National Cancer Society Malaysia, Kuala Lumpur, Malaysia. FAU - Lim, Joanne Bee Yin AU - Lim JBY AUID- ORCID: 0000-0002-2382-0453 AD - School of Humanities, Faculty of Art and Social Sciences, University of Nottingham Malaysia Campus, Semenyih, Malaysia. FAU - Alshagga, Mustafa AU - Alshagga M AUID- ORCID: 0000-0001-5064-2560 AD - Division of Biomedical Sciences, Faculty of Science and Engineering, University of Nottingham Malaysia Campus, Semenyih, Malaysia. LA - eng PT - Journal Article PT - Systematic Review DEP - 20250205 PL - Canada TA - JMIR Cancer JT - JMIR cancer JID - 101666844 SB - IM MH - Humans MH - *Mobile Applications MH - *Neoplasms/therapy/diet therapy MH - Nutritional Status MH - Quality of Life MH - Cancer Survivors MH - Female MH - Telemedicine PMC - PMC11840368 OTO - NOTNLM OT - PRISMA OT - body composition OT - cancer OT - diet OT - intervention OT - mHealth OT - mobile app OT - mobile health OT - mobile phone OT - nutrition OT - quality of life COIS- Conflicts of Interest: None declared. EDAT- 2025/02/05 18:20 MHDA- 2025/02/05 18:21 PMCR- 2025/02/05 CRDT- 2025/02/05 16:53 PHST- 2023/07/08 00:00 [received] PHST- 2024/10/30 00:00 [accepted] PHST- 2024/07/07 00:00 [revised] PHST- 2025/02/05 18:21 [medline] PHST- 2025/02/05 18:20 [pubmed] PHST- 2025/02/05 16:53 [entrez] PHST- 2025/02/05 00:00 [pmc-release] AID - v11i1e50662 [pii] AID - 10.2196/50662 [doi] PST - epublish SO - JMIR Cancer. 2025 Feb 5;11:e50662. doi: 10.2196/50662. PMID- 39906906 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250206 IS - 2667-3681 (Electronic) IS - 2667-3681 (Linking) VI - 13 DP - 2025 Mar TI - Comparing clinical practice habits among obesity medicine physicians by patient, physician and clinic factors. PG - 100157 LID - 10.1016/j.obpill.2025.100157 [doi] LID - 100157 AB - BACKGROUND: While clinical practice habits vary by patient, physician and clinic factors in primary care, limited research has examined whether differences exist in obesity medicine. Our objective was to compare practice habits by such factors among obesity medicine physicians certified by the American Board of Obesity Medicine (ABOM). METHODS: We conducted secondary analyses of cross-sectional data from the 2023 ABOM Practice Analysis Validation Survey. We included three obesity medicine practice habits - prescribing anti-obesity medications (AOMs), off-label prescribing of medications for weight reduction, and obesity medicine clinical practice hours (4-20 h/week versus >20 h/week). We included patient (patient population), physician (primary medical specialty, years of obesity medicine experience) and clinic factors (practice setting, geographic catchment, accepts insurance for obesity care). We conducted bivariate analyses using Chi(2) tests. RESULTS: Among 565 ABOM-certified physicians, 71.5 % had primary medical specialties within primary care and 9.2 % predominantly treated children/adolescents with obesity. Overall, 97.5 % prescribed AOMs and 85.1 % prescribed off-label medications for weight reduction. Fewer physicians who predominantly treated children/adolescents prescribed AOMs compared to physicians with no or limited treatment of children (88.5 % versus 98.4 % and 98.5 %, respectively; p < 0.001). Overall, 41.4 % reported practicing obesity medicine >20 h/week, which was more likely to occur as years of obesity medicine experience increased (i.e., 21.9 ​% among physicians with 1-2 years of experience versus 58.5 ​% with 10+ years; p ​< ​0.001). No significant differences in practice habits occurred by primary medical specialty, practice setting, geographic catchment, or accepting insurance. CONCLUSION: Our findings may suggest that ABOM-certified physicians have consistent obesity medication prescribing practices regardless of physician or clinic factors, which may be particularly important to patients seeking pharmacologic treatment. Most ABOM-certified physicians who predominantly treat children/adolescents prescribe obesity medications. These current rates are relatively higher than prior findings among pediatric ABOM-certified physicians, which might help support pharmacologic access for pediatric patients. CI - (c) 2025 The Authors. FAU - Rajagopal, Selvi AU - Rajagopal S AD - Johns Hopkins University School of Medicine, Baltimore, MD, USA. FAU - Wickham, Edmond P 3rd AU - Wickham EP 3rd AD - Virginia Commonwealth University School of Medicine, Richmond, VA, USA. FAU - Reid, Tirissa J AU - Reid TJ AD - Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. FAU - Brittan, Dana R AU - Brittan DR AD - American Board of Obesity Medicine, Denver, CO, USA. AD - American Board of Obesity Medicine Foundation, Denver, CO, USA. FAU - Korner, Judith AU - Korner J AD - Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. FAU - Gudzune, Kimberly A AU - Gudzune KA AD - American Board of Obesity Medicine Foundation, Denver, CO, USA. LA - eng PT - Journal Article DEP - 20250107 PL - United States TA - Obes Pillars JT - Obesity pillars JID - 9918697364706676 PMC - PMC11791150 OTO - NOTNLM OT - Anti-obesity agents OT - Certification OT - Obesity management OT - Physicians' practice patterns COIS- The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Kimberly Gudzune reports a relationship with 10.13039/501100004191Novo Nordisk that includes: consulting or advisory, funding grants, and travel reimbursement. Kimberly Gudzune reports a relationship with Eli Lilly and Company that includes: consulting or advisory and travel reimbursement. Edmond Wickham III reports a relationship with Novo Nordisk Inc that includes: funding grants. Judith Korner reports a relationship with Morphic Medical that includes: consulting or advisory. Judith Korner reports a relationship with Gila Therapeutics that includes: consulting or advisory. Judith Korner reports a relationship with Found that includes: consulting or advisory. Judith Korner reports a relationship with Apotex Inc that includes: consulting or advisory. Tirissa Reid received royalties from UpToDate. Judith Korner received royalties from UpToDate. Kimberly Gudzune received royalties from the Johns Hopkins ACG System. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/02/05 10:52 MHDA- 2025/02/05 10:53 PMCR- 2025/01/07 CRDT- 2025/02/05 04:28 PHST- 2024/12/02 00:00 [received] PHST- 2025/01/06 00:00 [revised] PHST- 2025/01/06 00:00 [accepted] PHST- 2025/02/05 10:53 [medline] PHST- 2025/02/05 10:52 [pubmed] PHST- 2025/02/05 04:28 [entrez] PHST- 2025/01/07 00:00 [pmc-release] AID - S2667-3681(25)00001-4 [pii] AID - 100157 [pii] AID - 10.1016/j.obpill.2025.100157 [doi] PST - epublish SO - Obes Pillars. 2025 Jan 7;13:100157. doi: 10.1016/j.obpill.2025.100157. eCollection 2025 Mar. PMID- 39904295 OWN - NLM STAT- MEDLINE DCOM- 20250505 LR - 20260903 IS - 1873-5347 (Electronic) IS - 0277-9536 (Linking) VI - 367 DP - 2025 Feb TI - Converging perspectives on the processes exacerbating adolescent obesity: An integrative systems approach. PG - 117706 LID - S0277-9536(25)00035-8 [pii] LID - 10.1016/j.socscimed.2025.117706 [doi] AB - Adolescent obesity is a complex public health challenge with steadily increasing and variable prevalence among countries. This paper synthesises the driving feedback mechanisms of adolescent obesity studied in the CO-CREATE project, furthering our understanding of the complexity of this issue. Using systems thinking principles and causal loop diagramming, we integrated the following knowledge and perspectives derived from diverse sources into a causal loop diagram (CLD): a systems map generated by adolescents through participatory modelling workshops, a comprehensive literature review, and input from subject-matter experts during validation workshops. We used a structured and iterative approach to include drivers and to identify feedback loops exacerbating adolescent obesity. The CLD identified 27 key feedback loops across four themes: twelve related to the commercial food environment, six to the physical activity environment, four to mental wellbeing and five to social norms. These loops indicate not only diet and physical activity as drivers of obesity but also stress and other emotional and social pressures. Recognising the imperative need to integrate the perspectives and experiences of adolescents into our analysis, this work advocates for the synthesis of experiential insights with empirical research. The integrated CLD can be used as a visual tool that fosters collaboration among stakeholders and engenders a more comprehensive and inclusive system understanding that can provide holistic intervention considerations to tackle adolescent obesity. Additionally, the CLD lays a foundation for subsequent quantitative modelling works to further address this issue and develop context-based approaches to prevention and evaluation of adolescent obesity. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Aguiar, Anaely AU - Aguiar A AD - System Dynamics Group, Department of Geography, University of Bergen, Bergen, Norway. Electronic address: anaely.aguiar@uib.no. FAU - Rajah, Jefferson K AU - Rajah JK AD - System Dynamics Group, Department of Geography, University of Bergen, Bergen, Norway. Electronic address: jefferson.rajah@uib.no. FAU - Conway-Moore, Kaitlin AU - Conway-Moore K AD - Faculty of Public Health Policy, London School of Hygiene & Tropical Medicine, London, UK. Electronic address: kaitlin.conway@lshtm.ac.uk. FAU - Savona, Natalie AU - Savona N AD - Faculty of Public Health Policy, London School of Hygiene & Tropical Medicine, London, UK. Electronic address: nataliesavona@cordisbright.co.uk. FAU - Knai, Cecile AU - Knai C AD - Faculty of Public Health Policy, London School of Hygiene & Tropical Medicine, London, UK. Electronic address: cecile.knai@lshtm.ac.uk. FAU - Vlad, Ioana AU - Vlad I AD - Policy and Public Affairs Department, World Cancer Research Fund International, London, UK. Electronic address: i.vlad@wcrf.org. FAU - Samdal, Oddrun AU - Samdal O AD - Department of Health Promotion and Development, Faculty of Psychology, University of Bergen, Bergen, Norway. Electronic address: oddrun.samdal@uib.no. FAU - Rutter, Harry AU - Rutter H AD - Department of Social & Policy Sciences, University of Bath, Bath, UK. Electronic address: hr526@bath.ac.uk. FAU - Lien, Nanna AU - Lien N AD - Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway. Electronic address: nanna.lien@medisin.uio.no. FAU - Kopainsky, Birgit AU - Kopainsky B AD - System Dynamics Group, Department of Geography, University of Bergen, Bergen, Norway. Electronic address: birgit.kopainsky@uib.no. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250122 PL - England TA - Soc Sci Med JT - Social science & medicine (1982) JID - 8303205 SB - IM MH - Humans MH - Adolescent MH - *Pediatric Obesity/psychology/etiology/epidemiology MH - Female MH - Exercise/psychology MH - Male MH - Systems Analysis OTO - NOTNLM OT - Adolescents OT - Causal loop diagram OT - Feedback loop OT - Obesity OT - System dynamics OT - Systems mapping OT - Systems thinking COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/02/05 00:19 MHDA- 2025/02/16 01:33 CRDT- 2025/02/04 18:11 PHST- 2024/02/23 00:00 [received] PHST- 2025/01/07 00:00 [revised] PHST- 2025/01/13 00:00 [accepted] PHST- 2025/02/16 01:33 [medline] PHST- 2025/02/05 00:19 [pubmed] PHST- 2025/02/04 18:11 [entrez] AID - S0277-9536(25)00035-8 [pii] AID - 10.1016/j.socscimed.2025.117706 [doi] PST - ppublish SO - Soc Sci Med. 2025 Feb;367:117706. doi: 10.1016/j.socscimed.2025.117706. Epub 2025 Jan 22. PMID- 39901311 OWN - NLM STAT- MEDLINE DCOM- 20250505 LR - 20261023 IS - 1545-5017 (Electronic) IS - 1545-5009 (Linking) VI - 72 IP - 4 DP - 2025 Apr TI - Screening Cognition, Sleep, and Physical Activity in Pediatric Oncology Long-Term Follow-Up Care. PG - e31579 LID - 10.1002/pbc.31579 [doi] AB - BACKGROUND: Children treated for pediatric cancer are at risk for cognitive late effects, as well as impairments in sleep and physical activity. The aim of the present study was to examine the psychometric properties of clinical screening of child- and caregiver-reported cognitive functioning, sleep, and physical activity and the relationship between cognitive functioning and health behaviors within a pediatric oncology long-term follow-up clinic. PROCEDURE: The study included a retrospective chart review of 99 caregivers and 80 children (8-17 years old) who completed the Conners Short Form (parent only) and PROMIS cognitive functioning, sleep-related impairment, sleep disturbance, and physical activity scales at the child's annual long-term follow-up visit. Test statistics and T-tests were used to assess psychometrics of the PROMIS scales. Bivariate correlations were used to examine the relationship between cognitive function and health behaviors. RESULTS: The child- and parent-report, short-version PROMIS cognitive functioning, sleep, and physical activity scales demonstrated high internal consistency and inter-rater reliability. High convergent validity was observed between PROMIS cognitive functioning and Conners Short Form. Caregiver- and child-reported cognitive functioning and health behaviors were significantly related (p /= 0.86, < 0.91) and high WHR (>/= 0.91) groups, and the classifications were compared. Strong agreement was observed between the two methods, with an intraclass correlation coefficient of 0.83 (p = 0.023995). The radar system achieved 82% accuracy in classifying participants into the correct abdominal obesity risk groups. Our findings demonstrate that FMCW radar can be a reliable tool for routine monitoring of central obesity. This technology addresses concerns about privacy and discomfort, making it suitable for widespread application in both clinical and non-clinical settings. CI - (c) 2025. The Author(s). FAU - Park, Jun Byung AU - Park JB AD - Department of Electronic Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea. FAU - Choi, Jinjoo AU - Choi J AD - Department of Pediatrics, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea. FAU - Na, Jae Yoon AU - Na JY AD - Department of Pediatrics, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea. FAU - Kim, Seung Hyun AU - Kim SH AD - Department of Pediatrics, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea. AD - Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 06351, Republic of Korea. FAU - Park, Hyun-Kyung AU - Park HK AD - Department of Pediatrics, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea. FAU - Yang, Seung AU - Yang S AD - Department of Pediatrics, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea. jxisfriend@hanyang.ac.kr. FAU - Cho, Sung Ho AU - Cho SH AD - Department of Electronic Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea. dragon@hanyang.ac.kr. LA - eng GR - NRF-2022R1A2C2008783/National Research Foundation of Korea/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250131 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Male MH - Adolescent MH - Child MH - *Waist-Hip Ratio/methods MH - *Machine Learning MH - *Radar MH - *Obesity, Abdominal/diagnosis PMC - PMC11785933 OTO - NOTNLM OT - Body mass index OT - Metabolic syndrome OT - Obesity, abdominal OT - Pediatric obesity OT - Radar OT - Waist-hip ratio COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/02/01 20:42 MHDA- 2025/02/01 20:43 PMCR- 2025/01/31 CRDT- 2025/01/31 23:27 PHST- 2024/10/25 00:00 [received] PHST- 2025/01/24 00:00 [accepted] PHST- 2025/02/01 20:43 [medline] PHST- 2025/02/01 20:42 [pubmed] PHST- 2025/01/31 23:27 [entrez] PHST- 2025/01/31 00:00 [pmc-release] AID - 10.1038/s41598-025-88098-x [pii] AID - 88098 [pii] AID - 10.1038/s41598-025-88098-x [doi] PST - epublish SO - Sci Rep. 2025 Jan 31;15(1):3911. doi: 10.1038/s41598-025-88098-x. PMID- 39889941 OWN - NLM STAT- MEDLINE DCOM- 20250504 LR - 20260703 IS - 1878-5476 (Electronic) IS - 1878-5476 (Linking) VI - 78 DP - 2025 May TI - All exercisers are passionate for exercise in some way: Taxometric evidence of the dimensionality of harmonious and obsessive passion for exercise. PG - 102816 LID - S1469-0292(25)00015-9 [pii] LID - 10.1016/j.psychsport.2025.102816 [doi] AB - The dualistic model of passion presents two important variables in the maintenance of physical exercise throughout life: harmonious passion and obsessive passion. Understanding whether the latent structure of these variables is better represented by classes (categorical) or factors (dimensional) can yield both theoretical and practical benefits. The objective of our study was to test, using taxometric analysis, whether these are dimensional latent variables (present in all exercisers, varying only in level) or categorical (present only in some exercisers). In a community sample of 1143 Brazilian exercisers with ages ranging from 18 to 71 years (M = 33.17; SD = 11.86), we conducted taxometric analysis using three non-redundant procedures at multiple base rates. Our results indicated the dimensionality of both harmonious and obsessive passion, which means that both are present, to some degree, in all exercisers. Evidence for harmonious passion was weaker due to high within-group correlations between the indicators. These findings can aid in the refinement of the construct and its measures, as well as in planning strategies to promote physical exercise by increasing levels of harmonious passion and preventing/treating exercise dependence through interventions aimed at reducing obsessive passion. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - Rocha, Rafael Moreton Alves da AU - Rocha RMAD AD - Universidade Sao Francisco, R. Waldemar Cesar da Silveira, 105 - Jardim Cura D'ars, Campinas, SP, Brazil. Electronic address: rafamoreton@hotmail.com. FAU - Hauck Filho, Nelson AU - Hauck Filho N AD - Universidade Sao Francisco, R. Waldemar Cesar da Silveira, 105 - Jardim Cura D'ars, Campinas, SP, Brazil. FAU - Romano, Amanda Rizzieri AU - Romano AR AD - Universidade Sao Francisco, R. Waldemar Cesar da Silveira, 105 - Jardim Cura D'ars, Campinas, SP, Brazil. FAU - Peixoto, Evandro Morais AU - Peixoto EM AD - Universidade Sao Francisco, R. Waldemar Cesar da Silveira, 105 - Jardim Cura D'ars, Campinas, SP, Brazil. LA - eng GR - Non-US Government Research Support type/ PT - Journal Article DEP - 20250129 PL - Netherlands TA - Psychol Sport Exerc JT - Psychology of sport and exercise JID - 101088724 SB - IM MH - Humans MH - Adult MH - *Exercise/psychology MH - Male MH - Adolescent MH - Female MH - Middle Aged MH - Aged MH - Young Adult MH - Brazil MH - *Obsessive Behavior/psychology MH - *Motivation MH - *Emotions OTO - NOTNLM OT - Latent structure OT - Physical exercise OT - Psychological assessment OT - Psychometrics COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/02/01 20:43 MHDA- 2025/03/10 07:59 CRDT- 2025/01/31 19:17 PHST- 2024/06/24 00:00 [received] PHST- 2025/01/22 00:00 [revised] PHST- 2025/01/28 00:00 [accepted] PHST- 2025/03/10 07:59 [medline] PHST- 2025/02/01 20:43 [pubmed] PHST- 2025/01/31 19:17 [entrez] AID - S1469-0292(25)00015-9 [pii] AID - 10.1016/j.psychsport.2025.102816 [doi] PST - ppublish SO - Psychol Sport Exerc. 2025 May;78:102816. doi: 10.1016/j.psychsport.2025.102816. Epub 2025 Jan 29. PMID- 39889520 OWN - NLM STAT- MEDLINE DCOM- 20250228 LR - 20250728 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 132 DP - 2025 Apr TI - Age-stratified validation and interrater reliability of the screening tool for nutritional risk for childhood cancer in hospitalized children. PG - 112685 LID - S0899-9007(25)00003-6 [pii] LID - 10.1016/j.nut.2025.112685 [doi] AB - OBJECTIVE: To evaluate the reliability, construct, and criterion validity of the screening tool for childhood cancer (SCAN), stratified by age in oncology patients admitted to a tertiary referral hospital. METHODS: Hospitalized children from birth to 18 years old, with an oncological diagnosis and expected length of stay (LOS) of >24 hours were included. Interrater and intrarrater agreements were used to evaluate the reliability of SCAN. Construct validity and criterion validity were explored in SCAN. Also, predictive validity was explored by comparing SCAN risk categories against LOS. RESULTS: Three hundred ninety-four children were included in the study. The scores obtained after dietitians and physicians used SCAN showed good agreement (ICC = 0.80, 95%CI 0.71-0.86, P < 0.001). The intrarrater agreement within the evaluation of the same dietitian to the same group of patients was also good (ICC = 0.83, 95%CI 0.75-0.88, P < 0.001). After applying SCAN, 66.2% of participants scored >3 points, classified as at risk of malnutrition. The agreement observed when comparing the risk classification given by the tool with the malnutrition assessment using anthropometry variables as the criterion reference was fair (kappa = 0.22, 95%CI 0.15-0.29, P < 0.001). Predictive validity indicated a slight agreement (kappa = 0.16, 95%CI 0.08-0.25, P < 0.001) between malnutrition risk by SCAN and LOS. When assessing construct validity, comparing the scores given by SCAN with those provided by STRONGkids, a fair agreement was found (kappa = 0.21, 95%CI 0.15-0.26, P < 0.001). CONCLUSIONS: Our results show that SCAN is a reliable and valid tool for detecting malnutrition in oncology pediatric patients upon hospital admission. CI - Copyright (c) 2025 Elsevier Inc. All rights reserved. FAU - Garcia-Guzman, Alda Daniela AU - Garcia-Guzman AD AD - Servicio de Oncologia Medica, Instituto Nacional de Pediatria; Ciudad de Mexico, Mexico; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud; Ciudad de Mexico, Mexico. FAU - Velasco-Hidalgo, Liliana AU - Velasco-Hidalgo L AD - Servicio de Oncologia Medica, Instituto Nacional de Pediatria; Ciudad de Mexico, Mexico; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud; Ciudad de Mexico, Mexico. FAU - Ortiz-Gutierrez, Salvador AU - Ortiz-Gutierrez S AD - Departamento de Fisiologia de la Nutricion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran; Ciudad de Mexico, Mexico. FAU - Aquino-Luna, Diana Monserrat AU - Aquino-Luna DM AD - Servicio de Oncologia Medica, Instituto Nacional de Pediatria; Ciudad de Mexico, Mexico. FAU - Becerra-Morales, Sandra Nayeli AU - Becerra-Morales SN AD - Departamento de Metodologia de la Investigacion, Instituto Nacional de Pediatria; Ciudad de Mexico, Mexico. FAU - Carmona-Jaimez, Kenya Shamira AU - Carmona-Jaimez KS AD - Servicio de Oncologia Medica, Instituto Nacional de Pediatria; Ciudad de Mexico, Mexico. FAU - Guevara-Cruz, Martha AU - Guevara-Cruz M AD - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud; Ciudad de Mexico, Mexico; Departamento de Fisiologia de la Nutricion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran; Ciudad de Mexico, Mexico. FAU - Pinzon-Navarro, Beatriz Adriana AU - Pinzon-Navarro BA AD - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud; Ciudad de Mexico, Mexico; Servicio de Gastroenterologia y Nutricion Pediatrica, Instituto Nacional de Pediatria; Ciudad de Mexico, Mexico. FAU - Baldwin-Monroy, Daffne Danae AU - Baldwin-Monroy DD AD - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud; Ciudad de Mexico, Mexico; Unidad de Terapia Intensiva, Instituto Nacional de Pediatria; Ciudad de Mexico, Mexico. FAU - Cardenas-Cardos, Rocio Del Socorro AU - Cardenas-Cardos RDS AD - Servicio de Oncologia Medica, Instituto Nacional de Pediatria; Ciudad de Mexico, Mexico. FAU - Zapata-Tarres, Marta Margarita AU - Zapata-Tarres MM AD - Comision Coordinadora de los Institutos Nacionales de Salud y Hospitales Federales de Referencia; Ciudad de Mexico, Mexico. FAU - Medina-Vera, Isabel AU - Medina-Vera I AD - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud; Ciudad de Mexico, Mexico; Departamento de Metodologia de la Investigacion, Instituto Nacional de Pediatria; Ciudad de Mexico, Mexico. Electronic address: isabelj.medinav@gmail.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250107 PL - United States TA - Nutrition JT - Nutrition (Burbank, Los Angeles County, Calif.) JID - 8802712 SB - IM MH - Humans MH - Child MH - *Neoplasms/complications MH - Male MH - Female MH - Reproducibility of Results MH - Child, Preschool MH - Adolescent MH - *Nutrition Assessment MH - Infant MH - *Child, Hospitalized/statistics & numerical data MH - *Malnutrition/diagnosis MH - Risk Assessment/methods MH - *Mass Screening/methods MH - Infant, Newborn MH - Observer Variation MH - Age Factors MH - Nutritional Status MH - Length of Stay MH - Hospitalization MH - Risk Factors OTO - NOTNLM OT - Cancer OT - Malnutrition OT - Malnutrition screening tools OT - Nutritional assessment OT - Pediatric COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Isabel Medina-Vera reports administrative support and article publishing charges were provided by National Institute of Paediatrics. Isabel Medina-Vera reports a relationship with National Institute of Paediatrics that includes: employment. There is no conflict of interest If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/02/01 20:44 MHDA- 2025/03/01 14:39 CRDT- 2025/01/31 18:10 PHST- 2024/10/24 00:00 [received] PHST- 2024/12/20 00:00 [revised] PHST- 2025/01/06 00:00 [accepted] PHST- 2025/03/01 14:39 [medline] PHST- 2025/02/01 20:44 [pubmed] PHST- 2025/01/31 18:10 [entrez] AID - S0899-9007(25)00003-6 [pii] AID - 10.1016/j.nut.2025.112685 [doi] PST - ppublish SO - Nutrition. 2025 Apr;132:112685. doi: 10.1016/j.nut.2025.112685. Epub 2025 Jan 7. PMID- 39888900 OWN - NLM STAT- MEDLINE DCOM- 20250504 LR - 20260928 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 1 DP - 2025 TI - Inadequate toothbrushing practice and associated factors among in-school adolescents in Malaysia: Findings from Global School Health Survey (GSHS) 2017. PG - e0317484 LID - 10.1371/journal.pone.0317484 [doi] LID - e0317484 AB - INTRODUCTION: Inadequate toothbrushing practice is define as brushing teeth less than two times per day. Inadequate toothbrushing during adolescence can lead to oral health problems and disease burden in adults. Moreover, inadequate practice can lead to low quality of life and inadequate self-esteem. OBJECTIVE: This study aimed to determine the prevalence of inadequate toothbrushing practice among adolescents aged 13 to 17 years in Malaysia and its association with sociodemographic and other related risky lifestyles. METHOD: This study was part of a national cross-sectional study, Global School Health Survey 2017. 27,497 students were agreed to participate in this study, with response of 89.2%. A validated self-administered bilingual, comprised of topics related to sociodemographic as well as adolescent health and risky lifestyles; substance use (alcohol, drug, smoking cigarettes), eating patterns, hygiene (inclusive of oral and hand hygiene), mental health status, lack of peer and parental/guardian support, truancy, physical activity, and body mass index (BMI). Analysis was performed using IBM SPSS for Windows version 26.0 involving complex sampling analysis and logistic regression. RESULTS: A total of 12.7% (95% CI: 11.8-13.6) of in-school adolescents had inadequate toothbrushing practices. Higher prevalence of inadequate toothbrushing were found among male, Indian, had ever drug use, had three or more lack of protective factors and had inadequate hand hygiene practices. Adolescents who had inadequate toothbrushing were significantly higher odd among males, Indian ethnic, ever drug use, inadequate hand hygiene practices and adolescents who had three or more lack of peer and parental/guardian support. CONCLUSION: Approximately 1 out of 10 adolescents had inadequate toothbrushing practices with several factors associated, such as male gender, Indian ethnicity, inadequate hand hygiene, ever drug use and lack of protective factors are identified to be associated. By emphasizing the significance of frequent brushing, we can encourage positive changes and reduce the burden of preventable dental problems on adolescents. CI - Copyright: (c) 2025 Mohamad Anuar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Mohamad Anuar, Mohamad Fuad AU - Mohamad Anuar MF AUID- ORCID: 0000-0003-4386-6667 AD - Biostatistics and Repository Data Sector, Office of NIH Manager, National Institute of Health, Ministry of Health Malaysia, Shah Alam, Malaysia. FAU - Mohamed, Nurulasmak AU - Mohamed N AD - Oral Health Epidemiology and Research Unit, Oral Health Program, Ministry of Health Malaysia, Putrajaya, W.P. Putrajaya, Malaysia. FAU - Awaluddin, S Maria AU - Awaluddin SM AD - Institute for Public Health, National Institute of Health, Ministry of Health Malaysia, Shah Alam, Selangor, Malaysia. FAU - Yacob, Habibah AU - Yacob H AD - Oral Health Regulations and Practice Division, Oral Health Program, Ministry of Health Malaysia, Putrajaya, W.P. Putrajaya, Malaysia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250131 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - Malaysia/epidemiology MH - *Toothbrushing/statistics & numerical data MH - Cross-Sectional Studies MH - Health Surveys MH - Schools MH - Oral Health MH - Students/statistics & numerical data MH - Prevalence PMC - PMC11785286 COIS- The authors declare that they have no competing/conflicts of interest. EDAT- 2025/01/31 18:16 MHDA- 2025/01/31 18:17 PMCR- 2025/01/31 CRDT- 2025/01/31 13:43 PHST- 2024/07/12 00:00 [received] PHST- 2024/12/30 00:00 [accepted] PHST- 2025/01/31 18:17 [medline] PHST- 2025/01/31 18:16 [pubmed] PHST- 2025/01/31 13:43 [entrez] PHST- 2025/01/31 00:00 [pmc-release] AID - PONE-D-24-26898 [pii] AID - 10.1371/journal.pone.0317484 [doi] PST - epublish SO - PLoS One. 2025 Jan 31;20(1):e0317484. doi: 10.1371/journal.pone.0317484. eCollection 2025. PMID- 39886744 OWN - NLM STAT- MEDLINE DCOM- 20250131 LR - 20250525 IS - 2047-2986 (Electronic) IS - 2047-2978 (Print) IS - 2047-2978 (Linking) VI - 14 DP - 2024 Dec 30 TI - Prediction of inpatient mortality in hospitalised children in low- and middle-income countries: An external validation of paediatric mortality risk scores. PG - 04235 LID - 10.7189/jogh.14.04235 [doi] LID - 04235 AB - BACKGROUND: Risk prediction tools for acutely ill children have been developed in high- and low-income settings, but few are validated or incorporated into clinical guidelines. We aimed to assess the performance of existing paediatric early warning scores for use in low- and middle-income countries using clinical data from a recent large multi-country study in Africa and South-Asia. METHODS: We used data (children across three nutritional strata) from the Childhood Acute Illness and Nutrition (CHAIN) Network cohort study (n = 3101). We assessed 10 scores where similar predictor variables were available in the CHAIN cohort. We evaluated performance using the area under the receiver operating curve (AUC) (primary outcome), sensitivity, specificity, positive and negative predictive value, and positive and negative likelihood ratio (secondary outcomes). RESULTS: Most scores showed poor discrimination, and all scores had low sensitivity. The paediatric early death index for Africa (AUC = 0.80; 95% confidence interval (CI) = 0.77-0.83), respiratory index of severity in children (AUC = 0.77; 95% CI = 0.74-0.81), and respiratory index of severity in children in Malawi (AUC = 0.78; 95% CI = 0.75-0.82) showed acceptable/good overall discrimination. Among children without wasting, most scores had acceptable/good performance, some even excellent. Poor discrimination was found for most scores among children with moderate and severe wasting or kwashiorkor. CONCLUSIONS: All scores demonstrated lower validation performance than originally reported. Among children without wasting, most risk prediction scores performed acceptably whilst in malnourished children they performed poorly. There is a need for a malnutrition specific score. Further research is needed on specific actions in responding to scores. Integration into future guidelines will require acknowledging staffing, resources and workflows. CI - Copyright (c) 2024 by the Journal of Global Health. All rights reserved. FAU - Brals, Daniella AU - Brals D AD - Amsterdam UMC, location University of Amsterdam, Department of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam, the Netherlands. FAU - Pradhan, Ananda AU - Pradhan A AD - Amsterdam UMC, location University of Amsterdam, Department of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam, the Netherlands. FAU - Andre-von Arnim, Amelie von Saint AU - Andre-von Arnim AVS AD - Departments of Paediatrics and Global Health, University of Washington, Seattle Children's, Seattle, Washington, USA. FAU - Oron, Assaf P AU - Oron AP AD - Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, USA. FAU - Ngari, Moses AU - Ngari M AD - Childhood Acute Illness and Nutrition Network, Nairobi, Kenya. AD - KEMRI, Wellcome Trust Research Programme, Kilifi, Kenya. FAU - Ngao, Narshion AU - Ngao N AD - Childhood Acute Illness and Nutrition Network, Nairobi, Kenya. FAU - Mupere, Ezekiel AU - Mupere E AD - Childhood Acute Illness and Nutrition Network, Nairobi, Kenya. AD - Nutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research (icddr,b), Dhaka, Bangladesh. AD - Department of Paediatrics and Child Health School of Medicine College of Health Sciences, Makerere University, Kampala, Uganda. FAU - Chisti, Mohammod J AU - Chisti MJ AD - Childhood Acute Illness and Nutrition Network, Nairobi, Kenya. AD - Nutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research (icddr,b), Dhaka, Bangladesh. FAU - Lwanga, Christopher AU - Lwanga C AD - Childhood Acute Illness and Nutrition Network, Nairobi, Kenya. FAU - Afroze, Farzana AU - Afroze F AD - Childhood Acute Illness and Nutrition Network, Nairobi, Kenya. AD - Nutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research (icddr,b), Dhaka, Bangladesh. FAU - Bandsma, Robert AU - Bandsma R AD - Childhood Acute Illness and Nutrition Network, Nairobi, Kenya. AD - Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada. AD - Translational Medicine Program, The Hospital for Sick Children, Toronto, Ontario, Canada. FAU - Walson, Judd L AU - Walson JL AD - Childhood Acute Illness and Nutrition Network, Nairobi, Kenya. AD - Departments of Global Health, Medicine, Paediatrics and Epidemiology, University of Washington, Seattle, Washington, USA. FAU - Berkley, James A AU - Berkley JA AD - Childhood Acute Illness and Nutrition Network, Nairobi, Kenya. AD - KEMRI, Wellcome Trust Research Programme, Kilifi, Kenya. AD - Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK. FAU - Voskuijl, Wieger AU - Voskuijl W AD - Amsterdam UMC, location University of Amsterdam, Department of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam, the Netherlands. AD - Childhood Acute Illness and Nutrition Network, Nairobi, Kenya. AD - Amsterdam UMC, location University of Amsterdam, Amsterdam Institute for Global Child Health, Emma Children's Hospital, Amsterdam, the Netherlands. AD - Department of Paediatrics and Child Health, Kamuzu University of Health Sciences, Blantyre, Malawi. LA - eng PT - Journal Article PT - Validation Study DEP - 20241230 PL - Scotland TA - J Glob Health JT - Journal of global health JID - 101578780 SB - IM MH - Humans MH - Child, Preschool MH - Infant MH - Female MH - Male MH - *Developing Countries/statistics & numerical data MH - Risk Assessment/methods MH - *Hospital Mortality MH - Child MH - Africa/epidemiology MH - *Child, Hospitalized/statistics & numerical data MH - Cohort Studies MH - *Child Mortality MH - *Early Warning Score MH - Infant, Newborn PMC - PMC11683851 COIS- Disclosure of interest: The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests. EDAT- 2025/01/31 06:16 MHDA- 2025/01/31 06:17 PMCR- 2024/12/30 CRDT- 2025/01/31 04:42 PHST- 2025/01/31 06:17 [medline] PHST- 2025/01/31 06:16 [pubmed] PHST- 2025/01/31 04:42 [entrez] PHST- 2024/12/30 00:00 [pmc-release] AID - jogh-14-04235 [pii] AID - 10.7189/jogh.14.04235 [doi] PST - epublish SO - J Glob Health. 2024 Dec 30;14:04235. doi: 10.7189/jogh.14.04235. PMID- 39885771 OWN - NLM STAT- MEDLINE DCOM- 20250528 LR - 20250531 IS - 1308-5735 (Electronic) IS - 1308-5727 (Print) VI - 17 IP - 2 DP - 2025 May 27 TI - Assessment of Quadriceps Muscle Strength and Thickness in Adolescents with Polycystic Ovary Syndrome: A Case-control and Longitudinal Follow-up Study. PG - 202-210 LID - 10.4274/jcrpe.galenos.2025.2024-12-5 [doi] AB - OBJECTIVE: To date, muscle strength and thickness have not been investigated in adolescents with polycystic ovary syndrome (PCOS). This study aimed to investigate whether differences exist in these parameters between adolescents with PCOS and healthy controls. Additionally, we evaluated the effects of six months combined oral contraceptive (COC) treatment on quadriceps muscle characteristics. METHODS: The study included adolescents diagnosed with PCOS and healthy peers. Dynamometers were used to measure knee muscle and hand grip strengths, and ultrasound was used to measure quadriceps muscle thickness. In the PCOS group, all measurements were repeated after six months of COCs treatment. RESULTS: There were 20 participants in each of the PCOS and control groups. There were no significant differences between the groups in terms of age, weight, height, pubertal stage, Physical Activity Questionnaire scores, quadriceps muscle thickness, grip strength and isokinetic knee strengths at baseline. Within the PCOS group, significant increase were observed in weight, height, quadriceps strength and lipid levels after six months of treatment (all p<0.05). Subgroup analysis of COC treatments revealed significantly greater gains in quadriceps muscle strength among levonorgestrel users (n=6) compared to those using cyproterone acetate users (n=13). CONCLUSION: Quadriceps muscle thickness and strength were comparable between adolescent with PCOS and controls, indicating no intrinsic muscular deficit. However, significantly greater improvements in quadriceps muscle strength were observed in those using levonorgestrel-containing COCs users compared to cyproterone acetate users. These findings suggest a potential role of progestin androgenicity in muscle strength. Further longitudinal studies with larger cohorts are warranted to validate these preliminary findings and to explore the impact of COCs with varying androgenic properties. CI - (c)Copyright 2025 by Turkish Society for Pediatric Endocrinology and Diabetes / The Journal of Clinical Research in Pediatric Endocrinology published by Galenos Publishing House. FAU - Guven, Ayse Gul AU - Guven AG AUID- ORCID: 0000-0003-3129-4315 AD - Hacettepe University Faculty of Medicine, Department of Pediatrics, Clinic of Adolescent Medicine, Ankara, Turkiye AD - Ankara University Faculty of Medicine, Department of Pediatrics, Clinic of Adolescent Medicine, Ankara, Turkiye FAU - Kara, Murat AU - Kara M AUID- ORCID: 0000-0003-0125-4865 AD - Hacettepe University Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Ankara, Turkiye FAU - Guneri, Sinem AU - Guneri S AUID- ORCID: 0000-0003-4171-9786 AD - Hacettepe University Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Ankara, Turkiye FAU - Aygun Ari, Demet AU - Aygun Ari D AUID- ORCID: 0000-0002-8701-6085 AD - Hacettepe University Faculty of Medicine, Department of Pediatrics, Clinic of Adolescent Medicine, Ankara, Turkiye FAU - Karabulut, Erdem AU - Karabulut E AUID- ORCID: 0000-0002-7811-8215 AD - Hacettepe University Faculty of Medicine, Department of Biostatistics, Ankara, Turkiye FAU - Demirbilek, Huseyin AU - Demirbilek H AUID- ORCID: 0000-0001-6374-5884 AD - Hacettepe University Faculty of Medicine, Department of Pediatrics, Clinic of Pediatric Endocrinology, Ankara, Turkiye FAU - Bozdag, Gurkan AU - Bozdag G AUID- ORCID: 0000-0002-6679-9623 AD - Hacettepe University Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara, Turkiye FAU - Derman, Orhan AU - Derman O AUID- ORCID: 0000-0003-4618-1110 AD - Hacettepe University Faculty of Medicine, Department of Pediatrics, Clinic of Adolescent Medicine, Ankara, Turkiye LA - eng PT - Journal Article DEP - 20250131 PL - Turkey TA - J Clin Res Pediatr Endocrinol JT - Journal of clinical research in pediatric endocrinology JID - 101519456 SB - IM MH - Humans MH - Female MH - Adolescent MH - *Quadriceps Muscle/drug effects/diagnostic imaging/physiopathology MH - *Muscle Strength/drug effects/physiology MH - Follow-Up Studies MH - *Polycystic Ovary Syndrome/physiopathology/drug therapy/pathology MH - Case-Control Studies MH - Longitudinal Studies MH - Hand Strength/physiology MH - Ultrasonography PMC - PMC12118324 OTO - NOTNLM OT - PCOS OT - isokinetic OT - levonorgestrel OT - oral contraceptive OT - ultrasound COIS- Conflict of interest: None declared. EDAT- 2025/01/31 06:16 MHDA- 2025/05/28 06:28 PMCR- 2025/05/27 CRDT- 2025/01/31 03:29 PHST- 2025/05/28 06:28 [medline] PHST- 2025/01/31 06:16 [pubmed] PHST- 2025/01/31 03:29 [entrez] PHST- 2025/05/27 00:00 [pmc-release] AID - 10.4274/jcrpe.galenos.2025.2024-12-5 [doi] PST - ppublish SO - J Clin Res Pediatr Endocrinol. 2025 May 27;17(2):202-210. doi: 10.4274/jcrpe.galenos.2025.2024-12-5. Epub 2025 Jan 31. PMID- 39885768 OWN - NLM STAT- MEDLINE DCOM- 20250822 LR - 20250827 IS - 1308-5735 (Electronic) IS - 1308-5727 (Print) VI - 17 IP - 3 DP - 2025 Aug 22 TI - Frequency of Polycystic Ovary Syndrome and "Being at Risk for Polycystic Ovary Syndrome" in Obese Adolescent Girls in Light of Current Definitions. PG - 318-325 LID - 10.4274/jcrpe.galenos.2025.2024-7-31 [doi] AB - OBJECTIVE: Obesity is associated with an increased risk of polycystic ovary syndrome (PCOS). It can be difficult to differentiate between PCOS and physiological oligomenorrhoea/anovulation in adolescent girls. To date, studies of the prevalence of PCOS in adolescents have predominantly used diagnostic criteria validated primarily in adult women. The aim of this study was to investigate the prevalence of PCOS in obese girls using the current diagnostic criteria for adolescents. METHODS: The diagnosis of PCOS was based on the presence of menstrual irregularity, clinical hyperandrogenism and hyperandrogenemia and the exclusion of other causes. Patients with one or two of these conditions were classified as "at risk for PCOS". The control group consisted of patients with obesity alone but no other comorbidity. RESULTS: A total of 421 patients were included in the study. The number of patients meeting the definition of PCOS was 35, representing a prevalence of 8.3%, while 200 patients (46%) were defined as "at risk for PCOS". The diagnostic value of the free androgen index (FAI) was found to be adequate, while other tests were poor. The cut-off values were 11 for FAI and 0.44 ng/mL for total testosterone, with optimal sensitivity and specificity. CONCLUSION: Despite the increasing number of studies, the diagnosis and management of PCOS in adolescents remains challenging. While efforts should be made to avoid overdiagnosis, it is also important to recognize that many more patients may be at risk of developing PCOS. CI - (c)Copyright 2025 by Turkish Society for Pediatric Endocrinology and Diabetes / The Journal of Clinical Research in Pediatric Endocrinology published by Galenos Publishing House. FAU - Yuksel, Ozlem AU - Yuksel O AUID- ORCID: 0009-0002-3784-6301 AD - University of Health Sciences Turkiye, Umraniye Training and Research Hospital, Clinic of Pediatrics, Istanbul, Turkiye FAU - Atmaca, Fatma Guliz AU - Atmaca FG AUID- ORCID: 0000-0003-2678-3886 AD - University of Health Sciences Turkiye, Umraniye Training and Research Hospital, Clinic of Pediatric Endocrinology, Istanbul, Turkiye FAU - Dursun, Fatma AU - Dursun F AUID- ORCID: 0000-0003-4880-8175 AD - University of Health Sciences Turkiye, Umraniye Training and Research Hospital, Clinic of Pediatric Endocrinology, Istanbul, Turkiye FAU - Seymen, Gulcan AU - Seymen G AUID- ORCID: 0000-0003-0614-4083 AD - University of Health Sciences Turkiye, Umraniye Training and Research Hospital, Clinic of Pediatric Endocrinology, Istanbul, Turkiye FAU - Atla, Pinar AU - Atla P AUID- ORCID: 0000-0001-7945-730X AD - University of Health Sciences Turkiye, Umraniye Training and Research Hospital, Clinic of Pediatric Endocrinology, Istanbul, Turkiye FAU - Altun, Esma Ebru AU - Altun EE AUID- ORCID: 0000-0001-5578-1770 AD - University of Health Sciences Turkiye, Umraniye Training and Research Hospital, Clinic of Pediatric Endocrinology, Istanbul, Turkiye FAU - Yasar, Ayse AU - Yasar A AUID- ORCID: 0000-0002-3335-7976 AD - University of Health Sciences Turkiye, Umraniye Training and Research Hospital, Clinic of Pediatric Endocrinology, Istanbul, Turkiye FAU - Kirmizibekmez, Heves AU - Kirmizibekmez H AUID- ORCID: 0000-0002-8663-3452 AD - University of Health Sciences Turkiye, Umraniye Training and Research Hospital, Clinic of Pediatric Endocrinology, Istanbul, Turkiye LA - eng PT - Journal Article DEP - 20250131 PL - Turkey TA - J Clin Res Pediatr Endocrinol JT - Journal of clinical research in pediatric endocrinology JID - 101519456 RN - 3XMK78S47O (Testosterone) SB - IM MH - Humans MH - Female MH - *Polycystic Ovary Syndrome/epidemiology/diagnosis/etiology/blood MH - Adolescent MH - Prevalence MH - Hyperandrogenism/epidemiology/diagnosis MH - Risk Factors MH - *Obesity/complications/epidemiology MH - *Pediatric Obesity/complications/epidemiology MH - Testosterone/blood PMC - PMC12372637 OTO - NOTNLM OT - Adolescent OT - free androgen index OT - total testosterone OT - obesity OT - polycystic ovary syndrome COIS- Conflict of interest: None declared. EDAT- 2025/01/31 06:17 MHDA- 2025/08/31 19:47 PMCR- 2025/08/22 CRDT- 2025/01/31 03:23 PHST- 2025/08/31 19:47 [medline] PHST- 2025/01/31 06:17 [pubmed] PHST- 2025/01/31 03:23 [entrez] PHST- 2025/08/22 00:00 [pmc-release] AID - 10.4274/jcrpe.galenos.2025.2024-7-31 [doi] PST - ppublish SO - J Clin Res Pediatr Endocrinol. 2025 Aug 22;17(3):318-325. doi: 10.4274/jcrpe.galenos.2025.2024-7-31. Epub 2025 Jan 31. PMID- 39883985 OWN - NLM STAT- MEDLINE DCOM- 20250504 LR - 20250525 IS - 1872-7646 (Electronic) IS - 0167-9457 (Linking) VI - 99 DP - 2025 Feb TI - The effect of run duration, gait variable and Lyapunov exponent algorithm on the inter-session reliability of local dynamic stability in healthy young people. PG - 103325 LID - S0167-9457(25)00006-5 [pii] LID - 10.1016/j.humov.2025.103325 [doi] AB - Local dynamic stability (LDS) of gait has been used to differentiate between healthy and injured populations, establishing its potential as an indicator of healthy gait and a new objective measure to assess gait function following injury. For LDS to be a reliable assessment tool of healthy gait progression during rehabilitation, it must provide consistent and sensitive inter-session measures. Methodological factors such as trial duration, gait variable, and Lyapunov Exponent (LyE) algorithm can influence LDS estimation and its reliability. Young people are a high-risk population for sport-related injuries, and running is a key activity during rehabilitation and is regularly assessed. Therefore, the effects of run duration, gait variable, and LyE algorithm choice on the reliability and sensitivity of inter-session LDS measures in young people were investigated. Sixteen healthy participants ran on a treadmill on two separate sessions (difference of 7 +/- 5 days). LDS was calculated using both the Rosenstein and Wolf algorithm for durations of 1-, 2-, 3-, 4- and 5-min of knee flexion angle and medio-lateral acceleration of the pelvis and thorax from each session. The relative and absolute reliability between sessions was calculated using the intraclass correlation coefficient and standard error of measurement. The sensitivity of inter-session LDS change was quantified by the minimal detectable change. Results showed that longer run durations produced higher relative reliability and a minimum run duration of 4 min is recommended to achieve moderate-to-good inter-session reliability across all gait variables and LyE algorithms. However, shorter durations of 2-3 min may still be sufficient when using medio-lateral pelvis acceleration or knee flexion angle, particularly with the Rosenstein algorithm, which also improves sensitivity to change. These findings provide practical guidance for methodological choices when calculating LDS in young people during running and support their potential use as reliable tools for monitoring gait function and tracking rehabilitation progress in young people following injury. CI - Copyright (c) 2025 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Kennerley, Adam S AU - Kennerley AS AD - Sports Engineering Research Group, Sport and Physical Activity Research Centre, Sheffield Hallam University, Sheffield, UK; Sport, Performance, and Nutrition Research Group, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Victoria, Australia. FAU - Dunn, Marcus AU - Dunn M AD - School of Energy, Geoscience, Infrastructure and Society, Institute for Life and Earth Sciences, Heriot-Watt University, Edinburgh, UK. FAU - Middleton, Kane AU - Middleton K AD - Sport, Performance, and Nutrition Research Group, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Victoria, Australia. FAU - Webster, Kate E AU - Webster KE AD - Sport, Performance, and Nutrition Research Group, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Victoria, Australia. FAU - Wheat, Jonathan AU - Wheat J AD - Department of Sport Sciences, Nottingham Trent University, Nottingham, UK. LA - eng PT - Journal Article DEP - 20250130 PL - Netherlands TA - Hum Mov Sci JT - Human movement science JID - 8300127 SB - IM MH - Humans MH - *Algorithms MH - Male MH - Female MH - *Gait/physiology MH - Young Adult MH - Reproducibility of Results MH - *Running/physiology MH - Biomechanical Phenomena MH - Exercise Test MH - *Postural Balance/physiology MH - Adult MH - Adolescent MH - Time Factors OTO - NOTNLM OT - Gait analysis OT - Injury OT - Nonlinear analysis OT - Rehabilitation OT - Running COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/01/31 00:21 MHDA- 2025/02/07 00:20 CRDT- 2025/01/30 18:07 PHST- 2024/09/04 00:00 [received] PHST- 2024/12/06 00:00 [revised] PHST- 2025/01/24 00:00 [accepted] PHST- 2025/02/07 00:20 [medline] PHST- 2025/01/31 00:21 [pubmed] PHST- 2025/01/30 18:07 [entrez] AID - S0167-9457(25)00006-5 [pii] AID - 10.1016/j.humov.2025.103325 [doi] PST - ppublish SO - Hum Mov Sci. 2025 Feb;99:103325. doi: 10.1016/j.humov.2025.103325. Epub 2025 Jan 30. PMID- 39882387 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260923 IS - 2398-502X (Print) IS - 2398-502X (Electronic) IS - 2398-502X (Linking) VI - 9 DP - 2024 TI - Protocol of the Nutritional, Psychosocial, and Environmental Determinants of Neurodevelopment and Child Mental Health (COINCIDE) study. PG - 486 LID - 10.12688/wellcomeopenres.22817.2 [doi] LID - 486 AB - BACKGROUND: Over 250 million children are developing sub-optimally due to their exposure to early life adversities. While previous studies have examined the independent effects of nutritional status, psychosocial adversities, and environmental pollutants on children's outcomes, little is known about their interaction and cumulative effects. OBJECTIVES: This study aims to investigate the independent, interaction, and cumulative effects of nutritional, psychosocial, and environmental factors on children's cognitive development and mental health in urban and rural India. It also seeks to explain pathways leading to inequities in child outcomes at the individual, household, and neighbourhood levels. METHODS: A mixed-methods prospective cohort study will be conducted on 1600 caregiver-child dyads (child age 3-10 years) in urban and rural India. Nutritional status, psychosocial adversities, environmental pollutants, and child mental health outcomes will be assessed using parent-report questionnaires. Performance-based measures will be used to assess cognitive outcomes. Venous blood and urine samples will be used to measure nutritional and pesticide biomarkers in 500 children. Indoor air pollution will be monitored in 200 households twice, during two seasons. Multilevel regression, weighted quantile sum regression, and Bayesian kernel machine regression will assess the individual and combined effects of exposures on child outcomes. Thematic analysis of in-depth interviews and focus group discussions will explore pathways to middle-and late childhood development inequities. DISCUSSION: The data will be used to formulate a Theory of Change (ToC) to explain the biological, psychosocial, and environmental origins of children's cognitive and mental health outcomes across the first decade of life in diverse Indian settings, which can inform interventions targets for promoting children's outcomes beyond the first 1000 days, potentially generalizable to similar under-resourced global settings. The COINCIDE research infrastructure will comprise a valuable global health resource, including prospective cohort data, validated study tools, and stored biological and environmental samples for future studies. CI - Copyright: (c) 2024 Lobo E et al. FAU - Lobo, Eunice AU - Lobo E AUID- ORCID: 0000-0002-0621-9295 AD - Indian Institute of Public Health-Bengaluru, Public Health Foundation of India, Bangalore, India. AD - Institute of Public Health Bengaluru, Bengaluru, Karnataka, India. AD - Family Medicine, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, Limburg, The Netherlands. FAU - R, Deepa AU - R D AD - Indian Institute of Public Health-Bengaluru, Public Health Foundation of India, Bangalore, India. FAU - Mandal, Siddhartha AU - Mandal S AD - Centre for Chronic Disease Control, New Delhi, India. AD - Centre for Health Analytics Research and Trends (CHART), Trivedi School of Biosciences, Ashoka University, Sonipat, India. FAU - Menon, Jyothi S AU - Menon JS AD - Centre for Chronic Disease Control, New Delhi, India. AD - Centre for Health Analytics Research and Trends (CHART), Trivedi School of Biosciences, Ashoka University, Sonipat, India. FAU - Roy, Aditi AU - Roy A AD - Centre for Chronic Disease Control, New Delhi, India. AD - Centre for Health Analytics Research and Trends (CHART), Trivedi School of Biosciences, Ashoka University, Sonipat, India. FAU - Dixit, Shweta AU - Dixit S AD - Centre for Health Analytics Research and Trends (CHART), Trivedi School of Biosciences, Ashoka University, Sonipat, India. FAU - Gupta, Ruby AU - Gupta R AD - Centre for Chronic Disease Control, New Delhi, India. AD - Centre for Health Analytics Research and Trends (CHART), Trivedi School of Biosciences, Ashoka University, Sonipat, India. FAU - Swaminathan, Sumathi AU - Swaminathan S AUID- ORCID: 0000-0002-4006-1049 AD - Division of Nutrition, St. John's Research Institute, Bangalore, India. FAU - Thankachan, Prashanth AU - Thankachan P AD - Division of Nutrition, St. John's Research Institute, Bangalore, India. FAU - Bhavnani, Supriya AU - Bhavnani S AUID- ORCID: 0000-0002-0855-2139 AD - Child Development Group, Sangath, New Delhi, India. FAU - Divan, Gauri AU - Divan G AUID- ORCID: 0000-0001-6212-8358 AD - Child Development Group, Sangath, New Delhi, India. FAU - Prabhakaran, Poornima AU - Prabhakaran P AD - Centre for Chronic Disease Control, New Delhi, India. AD - Centre for Health Analytics Research and Trends (CHART), Trivedi School of Biosciences, Ashoka University, Sonipat, India. FAU - van Schayck, Onno Cp AU - van Schayck OC AD - Family Medicine, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, Limburg, The Netherlands. FAU - Babu, Giridhara Rathnaiah AU - Babu GR AUID- ORCID: 0000-0003-4370-8933 AD - Department of Population Medicine, College of Medicine, QU Health, Qatar University, Doha, Qatar. FAU - Srinivas, Prashanth Nuggehalli AU - Srinivas PN AUID- ORCID: 0000-0003-0968-0826 AD - Institute of Public Health Bengaluru, Bengaluru, Karnataka, India. FAU - Mukherjee, Debarati AU - Mukherjee D AUID- ORCID: 0000-0003-3473-6537 AD - Indian Institute of Public Health-Bengaluru, Public Health Foundation of India, Bangalore, India. AD - Institute of Public Health Bengaluru, Bengaluru, Karnataka, India. CN - COINCIDE consortium LA - eng GR - WT_/Wellcome Trust/United Kingdom GR - IA/TSG/20/1/600023/WTDBT_/DBT-Wellcome Trust India Alliance/India PT - Journal Article DEP - 20241122 PL - England TA - Wellcome Open Res JT - Wellcome open research JID - 101696457 PMC - PMC11775445 OAB - Globally, millions of children face developmental challenges while growing up in adverse environments, including poor nutrition, abusive or neglectful relationships, and high pollutant exposure. Although these individual factors impact children's development, their combined effects on child outcomes, particularly in developing countries, is less understood. This study examines how nutrition, psychological stress, and exposure to air pollution, pesticides, and heavy metals, independently and collectively influence children's cognitive abilities and mental health in urban and rural India. Additionally, it will examine pathways leading to developmental inequalities among different individuals, households, and communities. This study will involve 1600 mother-child pairs when children are 3-9 years old, recruited from existing study cohorts in urban and rural India. Participants will answer comprehensive questions about their children's nutrition, psychological stress, pollutant exposure, and mental health. Children's cognitive abilities will be assessed using performance-based measures, such as activity sheets and video games. Blood and urine samples will be collected from 500 children to measure nutrition and pollution markers. Indoor air pollution will be monitored twice in 200 households during summer and winter. Advanced statistical methods will be used to analyse and interpret the individual and combined effects of these various exposures on children's cognitive and mental health outcomes. Interviews and group discussions will provide deeper insights into why certain individuals, households, and communities bear a disproportionate burden of poor child development. Our findings will inform a theoretical framework that explains how biological, social, and environmental factors affect children's outcomes through their first decade of life in diverse Indian settings, potentially applicable to similar global settings. This framework will then be used to identify intervention targets to improve children's outcomes. The COINCIDE project will also contribute valuable resources for global health research, including high-quality prospective data, study tools, and biological samples that could be leveraged in future studies. OABL- eng OTO - NOTNLM OT - air pollution OT - child mental health OT - cognitive development OT - early-life stress OT - global South OT - nurturing care framework OT - nutrition OT - pesticide COIS- No competing interests were disclosed. EDAT- 2025/01/30 11:06 MHDA- 2025/01/30 11:07 PMCR- 2024/11/22 CRDT- 2025/01/30 04:34 PHST- 2024/11/20 00:00 [accepted] PHST- 2025/01/30 11:07 [medline] PHST- 2025/01/30 11:06 [pubmed] PHST- 2025/01/30 04:34 [entrez] PHST- 2024/11/22 00:00 [pmc-release] AID - 10.12688/wellcomeopenres.22817.2 [doi] PST - epublish SO - Wellcome Open Res. 2024 Nov 22;9:486. doi: 10.12688/wellcomeopenres.22817.2. eCollection 2024. PMID- 39881428 OWN - NLM STAT- MEDLINE DCOM- 20250504 LR - 20250524 IS - 1466-447X (Electronic) IS - 0264-0414 (Linking) VI - 43 IP - 2 DP - 2025 Jan TI - An approach to determine the net predictive multivariate association pattern between cardiorespiratory fitness and a high-resolution physical activity spectrum in the presence of multicollinear covariates. PG - 188-195 LID - 10.1080/02640414.2024.2442253 [doi] AB - Multivariate pattern analysis was recently extended with covariate projections to solve the challenging task of modelling and interpreting associations in the presence of linear dependent multivariate covariates. Within a joint model, this approach allows quantification of the net association pattern between the outcome and the explanatory variables and between the individual covariates and these variables. The aim of this paper is to apply this methodology to establish the net multivariate association pattern between cardiorespiratory fitness (CRF) and a high-resolution linear dependent physical activity (PA) intensity descriptor derived from accelerometry in children and to validate the crucial sub-regions in the PA spectrum predicting CRF. We applied the Andersen test as a measure of CRF, a PA descriptor with 23 PA intensities, and included age, sex, and three nearly linear dependent measures of adiposity as covariates. Net predictive association patterns are calculated for unadjusted and adjusted data. The explained variance in CRF was reduced from 25% for unadjusted data to 7.2% for adjusted data, but the association pattern was robust and dominated by vigorous PA across models. Models of sub-regions of the PA spectrum validated the association pattern for the full model and the crucial influence of vigorous PA. FAU - Kvalheim, Olav Martin AU - Kvalheim OM AD - Department of Chemistry, University of Bergen, Bergen, Norway. FAU - Andersen, Lars Bo AU - Andersen LB AD - Department of Sport, Food and Natural Sciences, Western Norway University of Applied Sciences, Sogndal, Norway. FAU - Aadland, Eivind AU - Aadland E AUID- ORCID: 0000-0001-9654-2653 AD - Department of Sport, Food and Natural Sciences, Western Norway University of Applied Sciences, Sogndal, Norway. AD - Forde Health Trust, Forde, Norway. LA - eng PT - Journal Article DEP - 20250129 PL - England TA - J Sports Sci JT - Journal of sports sciences JID - 8405364 SB - IM MH - Humans MH - *Cardiorespiratory Fitness/physiology MH - Male MH - Female MH - Child MH - Accelerometry MH - *Exercise/physiology MH - Multivariate Analysis MH - Adiposity MH - Age Factors MH - Sex Factors OTO - NOTNLM OT - Net association pattern OT - accelerometry OT - cardiorespiratory fitness OT - confounders OT - multivariate covariates OT - physical activity spectrum EDAT- 2025/01/30 00:19 MHDA- 2025/03/12 11:33 CRDT- 2025/01/29 23:43 PHST- 2025/03/12 11:33 [medline] PHST- 2025/01/30 00:19 [pubmed] PHST- 2025/01/29 23:43 [entrez] AID - 10.1080/02640414.2024.2442253 [doi] PST - ppublish SO - J Sports Sci. 2025 Jan;43(2):188-195. doi: 10.1080/02640414.2024.2442253. Epub 2025 Jan 29. PMID- 39881412 OWN - NLM STAT- MEDLINE DCOM- 20250504 LR - 20250524 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 13 IP - 1 DP - 2025 Jan 29 TI - Turkish validity and reliability study of the psychological food involvement scale: PFIS-TR. PG - 84 LID - 10.1186/s40359-025-02413-9 [doi] LID - 84 AB - BACKGROUND: This study aimed to adapt the Psychological Food Involvement Scale (PFIS) to Turkish culture and test its validity and reliability. The PFIS measures individuals' psychological, emotional, and social relationships with food, which significantly impact eating behaviors and health. METHODS: The study was conducted with 478 participants aged 18-65. The PFIS underwent a six-stage translation and cultural adaptation process. Data collection was carried out via Google Forms, with participants completing a general information form, PFIS, and the Addiction-like Eating Behavior Scale (ALEBS). Reliability was assessed using the test-retest method. SPSS 24 was used for statistical evaluation, including internal consistency coefficient calculations, factor analysis, and correlation tests. RESULTS: The Kaiser-Meyer-Olkin value was 0.94, indicating an adequate sample size, and Bartlett's test of sphericity was significant (p < 0.05). Exploratory factor analysis revealed a four-factor structure explaining 79% of the variance, with factor loadings > 0.40 and eigenvalues > 1. Confirmatory factor analysis showed good fit indices: chi2 /sd = 2.28, GFI = 0.95, AGFI = 0.93 CFI = 0.98, NFI = 0.94, RMSEA = 0.05, SRMR = 0.04). Internal consistency analysis showed high reliability, with Cronbach's Alpha coefficients ranging from 0.86 to 0.94 across subscales. CONCLUSION: The Turkish version of the PFIS was found to be a valid and reliable tool for assessing psychological food involvement in the studied sample of the Turkish adult population. CI - (c) 2025. The Author(s). FAU - Sahin, Irem Nur AU - Sahin IN AUID- ORCID: 0000-0002-5446-9467 AD - Department of Nutrition and Dietetics, Faculty of Health Science, Istanbul Beykent University, Istanbul, Turkey. FAU - Atar, Aslihan AU - Atar A AUID- ORCID: 0000-0003-2941-4269 AD - Department of Nutrition and Dietetics, Faculty of Health Science, Istanbul Beykent University, Istanbul, Turkey. aslihanatar@beykent.edu.tr. AD - Department of Nutrition and Dietetics, Institute of Health Sciences, Istanbul Medipol University, Istanbul, Turkey. aslihanatar@beykent.edu.tr. AD - Department of Nutrition and Dietetics, Istanbul Beykent University, Cumhuriyet, Turgut Ozal Bv No: 147, Buyukcekmece, Istanbul, 34500, Turkey. aslihanatar@beykent.edu.tr. FAU - Yaman, Ozge AU - Yaman O AUID- ORCID: 0000-0002-0311-9395 AD - Department of Nursing, Faculty of Health Science, Istanbul Beykent University, Istanbul, Turkey. FAU - Pulat Demir, Halime AU - Pulat Demir H AUID- ORCID: 0000-0001-9509-4473 AD - Department of Nutrition and Dietetics, Faculty of Health Science, Istanbul Beykent University, Istanbul, Turkey. LA - eng PT - Journal Article PT - Validation Study DEP - 20250129 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Adult MH - Reproducibility of Results MH - Male MH - Turkey MH - Female MH - Middle Aged MH - Young Adult MH - Adolescent MH - *Psychometrics MH - *Feeding Behavior/psychology MH - Aged MH - Surveys and Questionnaires MH - Factor Analysis, Statistical PMC - PMC11776226 OTO - NOTNLM OT - Food addiction OT - Food involvement OT - Psychological food involvement scale OT - Turkish population OT - Validation COIS- Declarations. Ethics approval: "Ethics Committee Approval" dated 09.05.2024 and numbered E-10840098-202.3.02-3020 was obtained from Istanbul Medipol University Non-Interventional Research Ethics Committee for the study. This study was conducted using the principles of the Declaration of Helsinki and the rules of "research and publication ethics." Informed consent to participate was obtained from all of the participants in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/01/30 00:20 MHDA- 2025/01/30 11:06 PMCR- 2025/01/29 CRDT- 2025/01/29 23:43 PHST- 2024/10/29 00:00 [received] PHST- 2025/01/21 00:00 [accepted] PHST- 2025/01/30 11:06 [medline] PHST- 2025/01/30 00:20 [pubmed] PHST- 2025/01/29 23:43 [entrez] PHST- 2025/01/29 00:00 [pmc-release] AID - 10.1186/s40359-025-02413-9 [pii] AID - 2413 [pii] AID - 10.1186/s40359-025-02413-9 [doi] PST - epublish SO - BMC Psychol. 2025 Jan 29;13(1):84. doi: 10.1186/s40359-025-02413-9. PMID- 39881228 OWN - NLM STAT- MEDLINE DCOM- 20250504 LR - 20250524 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Jan 29 TI - Explore the factors related to the death of offspring under age five and appraise the hazard of child mortality using machine learning techniques in Bangladesh. PG - 360 LID - 10.1186/s12889-025-21460-w [doi] LID - 360 AB - BACKGROUND: Child mortality is a reliable and significant indicator of a nation's health. Although the child mortality rate in Bangladesh is declining over time, it still needs to drop even more in order to meet the Sustainable Development Goals (SDGs). Machine Learning models are one of the best tools for making more accurate and efficient forecasts and gaining in-depth knowledge. A deeper understanding is crucial for significantly reducing child mortality rates. Accurate predictions using machine learning models can empower authorities to implement timely interventions and raise awareness. So, the study aimed to explore the factors related to child mortality and assess the efficacy of various machine-learning models in predicting child mortality in Bangladesh. METHODS AND MATERIALS: About Forty-two thousand observations, except the missing observations, were extracted for this study from the Bangladesh Demographic and Health Survey (BDHS) data conducted in 2017-18. The survey utilized a two-stage stratified sampling method, selecting 675 enumeration areas-250 in urban settings and 425 in rural areas-resulting in effective data collection from 672 clusters and 20160 households. The Chi-square test and recursive feature elimination (RFE) are used to find the relevant risk factors of child mortality among the number of factors. Six ML-based algorithms were implemented for predicting child mortality, such as Naive Bayes, Classification and Regression Trees, Random Forest, C5.0 Classification, Gradient Boosting Machine, and Logistic Regression. Model evaluation metrics like accuracy, specificity, sensitivity, negative predictive value, F1 score, positive predictive value, k-fold cross-validation, and area under the curve (AUC) techniques were used to evaluate the performance of the models. RESULTS AND DISCUSSION: The child mortality rate is 8.2%, according to the data. The bivariate analysis showed that the child mortality rate was higher among the children whose mothers were uneducated, impoverished, underweight, aged 35-49, and gave birth before age 20. Families' water sources and religious connections had no statistically significant impact on child mortality. The prediction of child mortality using machine learning models is the main objective of this study. None of the machine learning models correctly classified dead occurrences. Therefore, this study conducted over-sampling and under-sampling analysis. Approximately 76727 and 6910 observations were sampled for over-sampling and under-sampling techniques, respectively. According to the findings of the over-sampling data, the Random Forest outperformed all the other models in terms of total performance based on training and testing sets, with an accuracy of seventy percent. The k-fold cross-validation approach demonstrated the Random Forest model's superior performance, and achieved the highest AUC (0.701). On the other hand, the Gradient Boosting Machine has the highest assessment for predicting child mortality in under-sampling analysis. The k-fold cross-validation also illustrated the better performance of the Gradient Boosting Machine. CONCLUSION: The Gradient Boosting Machine and Random Forest produce the best predictive power for classifying child mortality and may help to ameliorate policy decision-making in this regard. CI - (c) 2025. The Author(s). FAU - Rahman, Ashikur AU - Rahman A AD - Department of Statistics and Data Science, Jahangirnagar University, Dhaka, 1342, Bangladesh. FAU - Rahman, Md Habibur AU - Rahman MH AD - Department of Statistics and Data Science, Jahangirnagar University, Dhaka, 1342, Bangladesh. habib.drj@juniv.edu. LA - eng PT - Journal Article DEP - 20250129 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Bangladesh/epidemiology MH - Humans MH - *Machine Learning MH - *Child Mortality/trends MH - Child, Preschool MH - Infant MH - Female MH - Male MH - Risk Factors MH - Infant, Newborn MH - Adult MH - Health Surveys PMC - PMC11776272 OTO - NOTNLM OT - Accuracy OT - Bangladesh OT - Cross-validation OT - Machine learning OT - Mortality OT - Resampling COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/01/30 00:19 MHDA- 2025/01/30 00:20 PMCR- 2025/01/29 CRDT- 2025/01/29 23:35 PHST- 2023/09/07 00:00 [received] PHST- 2025/01/14 00:00 [accepted] PHST- 2025/01/30 00:20 [medline] PHST- 2025/01/30 00:19 [pubmed] PHST- 2025/01/29 23:35 [entrez] PHST- 2025/01/29 00:00 [pmc-release] AID - 10.1186/s12889-025-21460-w [pii] AID - 21460 [pii] AID - 10.1186/s12889-025-21460-w [doi] PST - epublish SO - BMC Public Health. 2025 Jan 29;25(1):360. doi: 10.1186/s12889-025-21460-w. PMID- 39875602 OWN - NLM STAT- MEDLINE DCOM- 20250829 LR - 20250902 IS - 1435-165X (Electronic) IS - 1018-8827 (Print) IS - 1018-8827 (Linking) VI - 34 IP - 8 DP - 2025 Aug TI - Can response to ADHD medication be predicted? PG - 2431-2442 LID - 10.1007/s00787-025-02650-8 [doi] AB - Predictors for the pharmacological effect of ADHD medication in children and adolescents are lacking. This study examined clinically relevant factors in a large (N = 638) prospective cohort reflecting real-world evidence. Children and adolescents aged 6-17 diagnosed with ADHD were evaluated at baseline and three months following ADHD medication initiation. The outcome was measured as a reduction in total SNAP-IV (Swanson Nolan and Pelham teacher and parent rating scale) score at three months compared to baseline. Outcome groups were defined as Responders (>/= 40% reduction), Intermediate Responders (>/= 20 to < 40% reduction), and Non-responders (< 20% reduction). Included independent variables were the Autism Spectrum Questionnaire (ASSQ), the Spence Children's Anxiety Scale (SCAS), the Pediatric Side Effect Checklist (P-SEC), anthropometrics measures, geographical region, relative age, Children s Global Assessment Scale (CGAS), Intelligence quotient (IQ), pharmacological treatment initiation month, ADHD symptom severity, ADHD presentation, and psychotic-like experiences. Multinomial logistic regression suggested that ADHD symptom severity, region, relative age, and stating ADHD medication at three-month follow-up were associated with the response outcome group. However, when validating the data with Bootstrap Forest, none of the variables were significant. Thus, in our large naturalistic cohort, we could not identify any clinically relevant factors that reliably predict pharmacological treatment outcomes.Trial registration: NCT02136147. CI - (c) 2025. The Author(s). FAU - Lilja, Maria M AU - Lilja MM AUID- ORCID: 0000-0003-0789-6906 AD - Department of Clinical Sciences, Child and Adolescent Psychiatry, Umea University, Umea, Sweden. Maria.lilja@umu.se. FAU - Lichtenstein, Paul AU - Lichtenstein P AUID- ORCID: 0000-0003-3037-5287 AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Serlachius, Eva AU - Serlachius E AUID- ORCID: 0000-0001-7115-6422 AD - Department of Clinical Sciences, Faculty of Medicine, Section of Child and Adolescent Psychiatry, Lund University, Lund, Sweden. AD - Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. FAU - Bhagia, Jyoti AU - Bhagia J AD - Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA. FAU - Malmberg, Kerstin AU - Malmberg K AUID- ORCID: 0009-0005-0005-7079 AD - Centre for Psychiatry Research, Department of Child and Adolescent Research Center, Affiliated to the Department of Clinical Neuroscience, Stockholm, Sweden. FAU - Malm, Christer AU - Malm C AUID- ORCID: 0000-0002-8436-2476 AD - Department of Community Medicine and Rehabilitation, Section of Sports Medicine, Umea School of Sport Sciences, Umea University, Umea, Sweden. FAU - Lenhard, Fabian AU - Lenhard F AUID- ORCID: 0000-0003-0930-6412 AD - Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. FAU - Halldner, Linda AU - Halldner L AUID- ORCID: 0000-0003-0561-5998 AD - Department of Clinical Sciences, Child and Adolescent Psychiatry, Umea University, Umea, Sweden. AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. LA - eng SI - ClinicalTrials.gov/NCT02136147 GR - Dnr RV-932912, Dnr RV-855991/BAS-ALF BUP Vasterbotten/ GR - Dnr RV-940805/BAS-ALF/ GR - Dnr RV-938804/Centrala ALF/ GR - FS 2.1.6-2408-18/the Medical Faculty at Umea University/ PT - Journal Article PT - Observational Study DEP - 20250129 PL - Germany TA - Eur Child Adolesc Psychiatry JT - European child & adolescent psychiatry JID - 9212296 RN - 0 (Central Nervous System Stimulants) SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Attention Deficit Disorder with Hyperactivity/drug therapy/diagnosis MH - *Central Nervous System Stimulants/therapeutic use MH - Prospective Studies MH - Treatment Outcome PMC - PMC12397174 OTO - NOTNLM OT - ADHD OT - Effect OT - Pharmacological treatment OT - Predictors OT - Response COIS- Declarations. Conflict of interest: The authors declare no competing interests. EDAT- 2025/01/29 00:20 MHDA- 2025/09/01 16:44 PMCR- 2025/01/29 CRDT- 2025/01/28 23:25 PHST- 2024/06/10 00:00 [received] PHST- 2025/01/15 00:00 [accepted] PHST- 2025/09/01 16:44 [medline] PHST- 2025/01/29 00:20 [pubmed] PHST- 2025/01/28 23:25 [entrez] PHST- 2025/01/29 00:00 [pmc-release] AID - 10.1007/s00787-025-02650-8 [pii] AID - 2650 [pii] AID - 10.1007/s00787-025-02650-8 [doi] PST - ppublish SO - Eur Child Adolesc Psychiatry. 2025 Aug;34(8):2431-2442. doi: 10.1007/s00787-025-02650-8. Epub 2025 Jan 29. PMID- 39875447 OWN - NLM STAT- MEDLINE DCOM- 20250128 LR - 20250709 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Jan 28 TI - The association between age at menarche (AAM) and cardiovascular disease (CVD) risk factors in the MASHAD cohort study. PG - 3518 LID - 10.1038/s41598-024-83763-z [doi] LID - 3518 AB - Age at menarche may be associated with cardiovascular disease risk factors in different ethnic groups. The purpose of this study was to identify the association of cardiovascular disease (CVD) risk factors with age at menarche (AAM) in Mashhad, the second biggest city in Iran. This was a cross- sectional study based on cohort data of 2353 women (35-65 years) from Mashhad, Iran for whom the age at menarche was reported. Baseline demographic, anthropometric data, and biochemical profiles were also collected. The levels of depression and anxiety were evaluated using a validated Persian version of the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). Multiple logistic regression models were used to examine the association between age at menarche with CVD risk factors. Anthropometric parameters, short stature, prevalence of diabetes, and CVD risk were significantly higher in women who were younger at menarche (AAM) in comparison to women with an older AAM. Women with a menstruating age of 11 years had a significantly higher weight (P < 0.001), higher BMI (P < 0.001), lower waist circumference (WC) (P = 0.004), higher hip circumference (HC) (P < 0.001) and higher waist-to-thigh ratio (WTR) (P < 0.001) than women with an AAM of >/= 15 years. University-educated women and employed women were most likely to have menarche at >/= 15 years (P < 0.001 and P = 0.012 respectively. In girls who menstruated at age 28.7 kg/m2, WC > 96 cm, HC > 105 cm and WTR > 61.96 were higher than girls who menstruated at 13 years old. The odds of height > 155 cm was higher in girls with menarche age of >/= 15 than 13 years and the odds of having depression scores greater than 12 was lower in menarche age group of >/= 15 years. The girls with menstruation age of 12 years had higher odds of having diabetes mellitus and HC > 105 cm than girls with menstruation age of 13 years. The odds of demi span exceeded 74 cm and height > 155 cm were higher in girls with menarche age of 14 than 13 years. AAM may be a useful factor to identify women at greater risk of CVD to implement appropriate preventive measures. CI - (c) 2025. The Author(s). FAU - Shabani, Niloofar AU - Shabani N AD - Department of Biostatistics, School of Health, Tehran University of Medical Sciences, Tehran, Iran. FAU - Saffar Soflaei, Sara AU - Saffar Soflaei S AD - Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. AD - International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, 99199-91766, Iran. FAU - Bavafa-Valenlia, Khadijeh AU - Bavafa-Valenlia K AD - Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Esmaeilzadeh, Nayereh AU - Esmaeilzadeh N AD - Department of Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Department of Basic Sciences, Lorestan University, Lorestan, Iran. FAU - Mohammadi-Bajgriran, Maryam AU - Mohammadi-Bajgriran M AD - Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Namazibaygi, Zahra AU - Namazibaygi Z AD - Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran. FAU - Moohebati, Mohsen AU - Moohebati M AD - Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Department of Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Ferns, Gordon A AU - Ferns GA AD - Division of Medical Education, Brighton and Sussex Medical School, Brighton, UK. FAU - Esmaily, Habibollah AU - Esmaily H AD - Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran. EsmailyH@mums.ac.ir. AD - Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. EsmailyH@mums.ac.ir. FAU - Ghayour-Mobarhan, Majid AU - Ghayour-Mobarhan M AD - Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. ghayourmobarhan@yahoo.com. AD - International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, 99199-91766, Iran. ghayourmobarhan@yahoo.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250128 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Menarche/physiology MH - Female MH - *Cardiovascular Diseases/epidemiology/etiology MH - Middle Aged MH - Iran/epidemiology MH - Adult MH - Cross-Sectional Studies MH - Aged MH - Age Factors MH - Risk Factors MH - *Heart Disease Risk Factors MH - Body Mass Index MH - Cohort Studies MH - Waist Circumference MH - Depression/epidemiology MH - Child PMC - PMC11775312 OTO - NOTNLM OT - Anthropometrics OT - Cardiovascular Diseases OT - Cohort Studies OT - Diabetes OT - Menarche OT - Puberty COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical statement: The study approval code from the MUMS ethics committee is IR.MUMS.REC.1386.250 which was approved according to Helsinki ethical principles in medical research. EDAT- 2025/01/29 00:20 MHDA- 2025/01/29 00:21 PMCR- 2025/01/28 CRDT- 2025/01/28 23:18 PHST- 2024/06/09 00:00 [received] PHST- 2024/12/17 00:00 [accepted] PHST- 2025/01/29 00:21 [medline] PHST- 2025/01/29 00:20 [pubmed] PHST- 2025/01/28 23:18 [entrez] PHST- 2025/01/28 00:00 [pmc-release] AID - 10.1038/s41598-024-83763-z [pii] AID - 83763 [pii] AID - 10.1038/s41598-024-83763-z [doi] PST - epublish SO - Sci Rep. 2025 Jan 28;15(1):3518. doi: 10.1038/s41598-024-83763-z. PMID- 39874617 OWN - NLM STAT- MEDLINE DCOM- 20250303 LR - 20250605 IS - 1872-7727 (Electronic) IS - 0720-048X (Linking) VI - 184 DP - 2025 Mar TI - Application value of split-bolus contrast injection combined with dual-energy CT scanning technology in pediatric CTU imaging. PG - 111949 LID - S0720-048X(25)00035-X [pii] LID - 10.1016/j.ejrad.2025.111949 [doi] AB - OBJECTIVE: To explore the clinical value of combining split-bolus contrast injection with dual-energy CT(DECT) scanning technology in pediatric computed tomography urography (CTU) imaging. METHODS: A total of 128 children aged 0-17 years were prospectively selected and randomly assigned to three groups: A, B, and C. For Group A, a high-pitch flash mode was employed, where a single bolus of contrast agent was followed by four-phase scanning (noncontrast, cortex, medulla, and excretory phases). In Group B, a dual-energy scanning mode was used with a split-bolus injection technique (50 % of the contrast agent was administered initially, followed by the remaining 50 % after 37-43 s), and the children underwent two-phase scanning (corticomedullary and excretory phases). In Group C, dual-energy scanning was similarly used with a split-bolus injection technique (65 % contrast agent was administered initially, followed by the remaining 35 % after 37-43 s), along with two-phase scanning (corticomedullary and excretory phases). Virtual noncontrast (VNC) images were obtained from the corticomedullary phase images using iodine subtraction techniques for Groups B and C. The image quality and radiation dose across the groups were compared and analysed. RESULTS: When the CT values of the renal cortex, erector spinae muscles, and standard deviation (SD) values were compared between Group A's cortical phase and Groups B and C's corticomedullary phases, the order was Group B > Group C > Group A (P < 0.05). The comparison of the cortical CNR and SNR between Group A's cortical phase and Groups B's and C's corticomedullary phases (cortices) revealed that Group C > Group B > Group A (P < 0.05). The comparison of the medullary CNR and SNR between Group A's medullary phase and Groups B and C's corticomedullary phases (medulla) showed that Group A > Group C > Group B (P < 0.05). The scores for the VNC images in Groups B and C were lower than those for the true noncontrast (TNC) images in Group A (P > 0.05). In the subjective evaluations of the corticomedullary and excretory phase images, Group B > Group C > Group A (P < 0.05). The comparison of radiation doses revealed that Group B < Group C < Group A (P < 0.05). A significant correlation was found between BMI and the effective radiation dose (P < 0.01), with a correlation coefficient of 0.62. CONCLUSION: The combination of split-bolus contrast injection and DECT enhances image quality in pediatric CTU while reducing radiation dosage. CI - Copyright (c) 2025. Published by Elsevier B.V. FAU - Chen, Hongqiao AU - Chen H AD - Department of Radiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, China; Department of Radiology University Town Hospital of Chongqing Medical University, China. Electronic address: 527702430@qq.com. FAU - Deng, Zhikai AU - Deng Z AD - Department of Radiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, China; Jishou University School of Medicine, China. Electronic address: 2324540012@qq.com. FAU - Tan, Ting AU - Tan T AD - Department of Radiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, China; Jishou University School of Medicine, China. Electronic address: 2502714117@qq.com. FAU - Li, Siwei AU - Li S AD - Department of Radiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, China; The Second Affiliated Hospital of Chongqing Medical University, China. Electronic address: 1340723165@qq.com. FAU - Qian, Fangfang AU - Qian F AD - Department of Radiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, China. Electronic address: 765841220@qq.com. FAU - He, Ling AU - He L AD - Department of Radiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, China. Electronic address: 480056@hospital.cqmu.edu.cn. FAU - Tang, Shilong AU - Tang S AD - Department of Radiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, China. Electronic address: sltang66@163.com. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20250124 PL - Ireland TA - Eur J Radiol JT - European journal of radiology JID - 8106411 RN - 0 (Contrast Media) RN - 4419T9MX03 (Iohexol) SB - IM MH - Humans MH - *Contrast Media/administration & dosage MH - Child, Preschool MH - Child MH - *Tomography, X-Ray Computed/methods MH - Infant MH - Adolescent MH - Female MH - Male MH - *Radiography, Dual-Energy Scanned Projection/methods MH - *Urography/methods MH - Infant, Newborn MH - Reproducibility of Results MH - Sensitivity and Specificity MH - *Iohexol/administration & dosage/analogs & derivatives OTO - NOTNLM OT - CTU OT - Children OT - DECT OT - Radiation dosage OT - Split-bolus contrast injection COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/01/28 18:21 MHDA- 2025/03/04 00:22 CRDT- 2025/01/28 18:00 PHST- 2024/09/16 00:00 [received] PHST- 2025/01/01 00:00 [revised] PHST- 2025/01/23 00:00 [accepted] PHST- 2025/03/04 00:22 [medline] PHST- 2025/01/28 18:21 [pubmed] PHST- 2025/01/28 18:00 [entrez] AID - S0720-048X(25)00035-X [pii] AID - 10.1016/j.ejrad.2025.111949 [doi] PST - ppublish SO - Eur J Radiol. 2025 Mar;184:111949. doi: 10.1016/j.ejrad.2025.111949. Epub 2025 Jan 24. PMID- 39868842 OWN - NLM STAT- MEDLINE DCOM- 20250411 LR - 20250411 IS - 1097-0010 (Electronic) IS - 0022-5142 (Linking) VI - 105 IP - 7 DP - 2025 May TI - Diet quality indicators and organic food consumption in mothers of young children. PG - 3900-3910 LID - 10.1002/jsfa.14143 [doi] AB - BACKGROUND: The health benefits of organic food provide one reason for consuming it. Various studies have shown that regular organic food consumers (REG eco-con) follow a healthier diet. However, this topic has not been explored in Poland. This study aimed to evaluate the diet quality of mothers with children under 6 years old, residing in three provinces of Poland, who consumed organic food at varying frequencies. Data were collected using validated questionnaires. RESULTS: Among the mothers surveyed (N = 667), 84% achieved an average Diet Quality Index (DQI) score, indicating a neutral impact of their diet on health. Meanwhile, 15% of respondents exhibited diets with a high intensity of health-promoting characteristics. Women with a higher frequency of organic food consumption displayed more health-promoting dietary behavior. Regular organic food consumers demonstrated significantly higher DQI and Pro-Healthy Diet Index (pHDI) scores than those with lower organic food consumption frequency. The REG eco-con mothers also reported significantly more frequent consumption of vegetables, fruit, whole-grain bread and cereals, fermented dairy products, legumes, and fish. Respondents who rated their state of health as better than that of their peers were characterized by more frequent consumption of organic food. CONCLUSION: An organic diet may play a significant role in an individual's quality of life and well-being. The results of this study could be relevant for the organic food sector and policymakers in developing nutritional transformation towards sustainability. (c) 2025 Society of Chemical Industry. CI - (c) 2025 Society of Chemical Industry. FAU - Wos, Karolina AU - Wos K AUID- ORCID: 0000-0003-0184-3088 AD - Department of Functional and Organic Food, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (SGGW), Warsaw, Poland. FAU - Dobrowolski, Hubert AU - Dobrowolski H AUID- ORCID: 0000-0002-7445-8036 AD - University of Economics and Human Sciences in Warsaw, School of Medical & Health Sciences, Warsaw, Poland. FAU - Gajewska, Danuta AU - Gajewska D AD - Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (SGGW), Warsaw, Poland. FAU - Rembialkowska, Ewa AU - Rembialkowska E AD - Department of Functional and Organic Food, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (SGGW), Warsaw, Poland. LA - eng GR - This research was funded by The Carrefour Foundation registered in France at BOULOGNE-BILLANCOURT(92100)-33, avenue Emile Zola. Funding registered in WULS under no 2019/R/145/ PT - Journal Article DEP - 20250127 PL - England TA - J Sci Food Agric JT - Journal of the science of food and agriculture JID - 0376334 SB - IM MH - Humans MH - Female MH - *Mothers/psychology MH - Poland MH - Adult MH - *Food, Organic/analysis MH - Child, Preschool MH - *Diet MH - Vegetables/metabolism MH - Feeding Behavior MH - Fruit/metabolism MH - Infant MH - Surveys and Questionnaires MH - Quality of Life MH - Diet, Healthy MH - Male MH - Young Adult MH - Child OTO - NOTNLM OT - Diet Quality Index (DQI) OT - diet quality OT - mother's diet OT - organic consumer OT - organic food EDAT- 2025/01/27 12:24 MHDA- 2025/04/11 18:26 CRDT- 2025/01/27 09:05 PHST- 2024/10/01 00:00 [revised] PHST- 2024/04/30 00:00 [received] PHST- 2025/01/07 00:00 [accepted] PHST- 2025/04/11 18:26 [medline] PHST- 2025/01/27 12:24 [pubmed] PHST- 2025/01/27 09:05 [entrez] AID - 10.1002/jsfa.14143 [doi] PST - ppublish SO - J Sci Food Agric. 2025 May;105(7):3900-3910. doi: 10.1002/jsfa.14143. Epub 2025 Jan 27. PMID- 39868685 OWN - NLM STAT- MEDLINE DCOM- 20250128 LR - 20250128 IS - 1460-2210 (Electronic) IS - 0141-5387 (Linking) VI - 47 IP - 1 DP - 2024 Dec 4 TI - Prevalence and risks of sleep bruxism in children and adolescents presenting for orthodontic treatment. LID - cjaf002 [pii] LID - 10.1093/ejo/cjaf002 [doi] AB - OBJECTIVES: This study determined the prevalence and risks of definite sleep bruxism (SB) among children and adolescents presenting for orthodontic treatment. METHODS: This was a cross-sectional study of 7-16-year-old subjects pursuing orthodontic treatment for the first time. The presence or absence of SB was determined using an overnight mandibular movement monitoring inertial measurement sensor, worn by each participant for two consecutive nights. Data from the sensor were extrapolated, then processed and analyzed to automatically identify rhythmic masticatory muscle activity for SB assessment. SB risks were evaluated from previously validated questionnaires, clinical examinations, lateral cephalometric radiographs, and digital study models. RESULTS: A total of 87 subjects with a mean age of 12.82 years +/- 2.24 and body mass index of 21.45 +/- 5.49 participated in the study. The prevalence of SB was 60.7%. Multiple linear regression analysis revealed that SB had statistically significant association with microarousals (events/h) (beta=0.31, 95% Confidence Interval [CI] 0.25-0.36, P < .001) and maxillary 6-6 dimension (mm) (beta = 0.08, 95% CI 0.02-0.13, P = .008). A second model excluding microarousals showed that SB had a statistically significant association with sleep efficiency (SE) percentage (beta = -0.15, 95% CI -0.28 to -0.01, P = .026) and obstructive respiratory disturbance index (ORDI) (events/h) (beta = 0.33, 95% CI 0.15-0.51, P < .001). CONCLUSIONS AND IMPLICATIONS: In a growing orthodontic population, definite SB is very common. SB is related to microarousals, maxillary intermolar width, SE percentage, and ORDI. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of the European Orthodontic Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Koch, Ryan AU - Koch R AD - Private Practice, 4376 Lakeville Rd, Geneseo, NY 14454, United States. FAU - Monegro, Alberto AU - Monegro A AD - Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, 955 Main Street, Buffalo, NY 14203, United States. FAU - Warunek, Stephen AU - Warunek S AD - Department of Orthodontics, School of Dental Medicine, University at Buffalo, 3435 Main Street, Buffalo, NY 14214, United States. FAU - Tanberg, William AU - Tanberg W AD - Department of Orthodontics, School of Dental Medicine, University at Buffalo, 3435 Main Street, Buffalo, NY 14214, United States. AD - Department of Biostatistics, School of Public Health and Health Professions, University at Buffalo, 401 Kimball Tower, Buffalo, NY 14214, United States. FAU - Al-Jewair, Thikriat AU - Al-Jewair T AUID- ORCID: 0000-0001-6857-747X AD - Department of Orthodontics, School of Dental Medicine, University at Buffalo, 3435 Main Street, Buffalo, NY 14214, United States. LA - eng GR - American Association of orthodontists Foundation/ PT - Journal Article PL - England TA - Eur J Orthod JT - European journal of orthodontics JID - 7909010 SB - IM MH - *Sleep Bruxism/complications/epidemiology MH - *Orthodontics/instrumentation/methods MH - Humans MH - Male MH - Female MH - Child MH - Adolescent MH - Cross-Sectional Studies MH - Prevalence MH - Masticatory Muscles/pathology MH - Muscle Contraction MH - Sleep Quality MH - Surveys and Questionnaires MH - Cephalometry MH - Maxilla/pathology OTO - NOTNLM OT - adolescent OT - mandibular movement OT - sleep bruxism EDAT- 2025/01/27 12:25 MHDA- 2025/01/27 12:26 CRDT- 2025/01/27 07:53 PHST- 2025/01/27 12:26 [medline] PHST- 2025/01/27 12:25 [pubmed] PHST- 2025/01/27 07:53 [entrez] AID - 7983927 [pii] AID - 10.1093/ejo/cjaf002 [doi] PST - ppublish SO - Eur J Orthod. 2024 Dec 4;47(1):cjaf002. doi: 10.1093/ejo/cjaf002. PMID- 39864473 OWN - NLM STAT- MEDLINE DCOM- 20250609 LR - 20250609 IS - 1532-8503 (Electronic) IS - 1051-2276 (Linking) VI - 35 IP - 3 DP - 2025 May TI - Diet Quality Components and Gut Microbiota of Patients on Peritoneal Dialysis. PG - 454-462 LID - S1051-2276(25)00010-X [pii] LID - 10.1053/j.jrn.2025.01.001 [doi] AB - OBJECTIVES: To evaluate the associations between the quality of the diet and its components and microbial diversity and composition in peritoneal dialysis (PD) patients. DESIGN AND METHODS: This cross-sectional study included PD patients for at least 3 months, aged 18-75 years and clinically stable. The Diet Quality Index (DQI), validated for the Brazilian population, is based on the energy density of 11 components ("sugar and sweets;" "beef, pork, and processed meat;" "refined grains and breads;" "animal fat;" "poultry, fish, and eggs;" "whole cereals, tubers, and roots;" "fruits"; "nonstarch vegetables;" "legumes and nuts;" "milk and dairy products;" and "vegetable oil"). A proportional score-based on the adequacy of the intake to Brazilian dietary guidelines-is calculated, and a final score ranged from 0 (worse) to 100 (better) is obtained. Fecal samples were collected at home, in a sterile material, kept refrigerated, and delivered to the clinic within 12 hours; alpha-diversity indices (Observed operational taxonomic units, Chao-1, Shannon's, Gini-Simpson's, Pielou eveness, and Faith phylogenetics) and microbial profile were determined by 16S ribosomal DNA with polymerase chain reaction-amplification and sequenced on an Illumina MiSeq platform. RESULTS: Forty-three participants were included (53.5% men, 52.4 +/- 14.1 years, body mass index: 25.9 +/- 4.1 kg/m(2), 30.2% had diabetes mellitus). DQI score was 50.5 (41.9-54.9). The lowest energy density was for the components "animal fat" and "whole cereals and breads, tubers, and roots," and the highest were for "refined grains and bread" and "beef, pork, and processed meat." Diversity indices and Enterorhabdus genus were directly associated with the energy density of the components "whole cereals and breads, tubers, and roots" and inversely with "refined grains and bread," after adjustments for age and diabetes. CONCLUSIONS: Even low, the intake of whole cereals, tubers, and roots has the potential to positively influence the microbiota profile in PD patients. CI - Copyright (c) 2025 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved. FAU - Ramos, Christiane Ishikawa AU - Ramos CI AD - Division of Nephrology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil. FAU - de Andrade, Laila Santos AU - de Andrade LS AD - Nutrition Program, Universidade Federal de Sao Paulo, Sao Paulo, Brazil. FAU - Teixeira, Renata Rodrigues AU - Teixeira RR AD - Nutrition Program, Universidade Federal de Sao Paulo, Sao Paulo, Brazil. FAU - Pereira, Natalia Barros Ferreira AU - Pereira NBF AD - Nutrition Program, Universidade Federal de Sao Paulo, Sao Paulo, Brazil. FAU - da Silva Lima, Fabiana AU - da Silva Lima F AD - School of Pharmaceutical Sciences, University of Sao Paulo (USP), Sao Paulo, Brazil. FAU - Hoffmann, Christian AU - Hoffmann C AD - School of Pharmaceutical Sciences, University of Sao Paulo (USP), Sao Paulo, Brazil. FAU - Cuppari, Lilian AU - Cuppari L AD - Division of Nephrology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil; Nutrition Program, Universidade Federal de Sao Paulo, Sao Paulo, Brazil. Electronic address: lcuppari@uol.com.br. LA - eng PT - Journal Article DEP - 20250124 PL - United States TA - J Ren Nutr JT - Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation JID - 9112938 SB - IM MH - Humans MH - Middle Aged MH - Adult MH - Cross-Sectional Studies MH - *Gastrointestinal Microbiome/physiology MH - Male MH - Female MH - *Diet/standards MH - Aged MH - Brazil MH - *Peritoneal Dialysis MH - Young Adult MH - Adolescent MH - Feces/microbiology OTO - NOTNLM OT - chronic kidney disease OT - dietary intake OT - microbiome OT - whole grains OT - alpha-diversity EDAT- 2025/01/27 00:20 MHDA- 2025/06/10 00:30 CRDT- 2025/01/26 19:13 PHST- 2024/01/16 00:00 [received] PHST- 2024/12/10 00:00 [revised] PHST- 2025/01/09 00:00 [accepted] PHST- 2025/06/10 00:30 [medline] PHST- 2025/01/27 00:20 [pubmed] PHST- 2025/01/26 19:13 [entrez] AID - S1051-2276(25)00010-X [pii] AID - 10.1053/j.jrn.2025.01.001 [doi] PST - ppublish SO - J Ren Nutr. 2025 May;35(3):454-462. doi: 10.1053/j.jrn.2025.01.001. Epub 2025 Jan 24. PMID- 39863763 OWN - NLM STAT- MEDLINE DCOM- 20250503 LR - 20250627 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Jan 25 TI - Machine Learning-Based predictive model for adolescent metabolic syndrome: Utilizing data from NHANES 2007-2016. PG - 3274 LID - 10.1038/s41598-025-88156-4 [doi] LID - 3274 AB - Metabolic syndrome (Mets) in adolescents is a growing public health issue linked to obesity, hypertension, and insulin resistance, increasing risks of cardiovascular disease and mental health problems. Early detection and intervention are crucial but often hindered by complex diagnostic requirements. This study aims to develop a predictive model using NHANES data, excluding biochemical indicators, to provide a simple, cost-effective tool for large-scale, non-medical screening and early prevention of adolescent MetS. After excluding adolescents with missing diagnostic variables, the dataset included 2,459 adolescents via NHANES data from 2007-2016. We used LASSO regression and 20-fold cross-validation to screen for the variables with the greatest predictive value. The dataset was divided into training and validation sets in a 7:3 ratio, and SMOTE was used to expand the training set with a ratio of 1:1. Based on the training set, we built eight machine learning models and a multifactor logistic regression model, evaluating nine predictive models in total. After evaluating all models using the confusion matrix, calibration curves and decision curves, the LGB model had the best predictive performance, with an AUC of 0.969, a Youden index of 0.923, accuracy of 0.978, F1 score of 0.989, and Kappa value of 0.800. We further interpreted the LGB model using SHAP, the SHAP hive plot showed that the predictor variables were, in descending order of importance, BMI age sex-specific percentage, weight, upper arm circumference, thigh length, and race. Finally, we deployed it online for broader accessibility. The predictive models we developed and validated demonstrated high performance, making them suitable for large-scale, non-medical primary screening and early warning of adolescent Metabolic syndrome. The online deployment of the model allows for practical use in community and school settings, promoting early intervention and public health improvement. CI - (c) 2025. The Author(s). FAU - Zhang, Yu-Zhen AU - Zhang YZ AD - Department of Anesthesiology and Surgical Intensive Care Unit, Kunming Children's Hospital, Kunming, Yunnan, China. FAU - Wu, Hai-Ying AU - Wu HY AD - Department of Emergency, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. FAU - Ma, Run-Wei AU - Ma RW AD - Department of Cardiac Surgery, Fuwai Yunnan Hospital, Chinese Academy of Medical Sciences/Affiliated Cardiovascular Hospital of Kunming Medical University, Kunming, Yunnan, China. FAU - Feng, Bo AU - Feng B AD - Department of Anesthesiology and Surgical Intensive Care Unit, Kunming Children's Hospital, Kunming, Yunnan, China. FAU - Yang, Rui AU - Yang R AD - Department of Clinical Laboratory, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. FAU - Chen, Xiao-Gang AU - Chen XG AD - Department of Anesthesiology and Surgical Intensive Care Unit, Kunming Children's Hospital, Kunming, Yunnan, China. FAU - Li, Min-Xiao AU - Li MX AD - Department of Anesthesiology and Surgical Intensive Care Unit, Kunming Children's Hospital, Kunming, Yunnan, China. FAU - Cheng, Li-Ming AU - Cheng LM AD - Department of Anesthesiology and Surgical Intensive Care Unit, Kunming Children's Hospital, Kunming, Yunnan, China. Medcheng@163.com. LA - eng PT - Journal Article DEP - 20250125 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Metabolic Syndrome/diagnosis/epidemiology MH - Adolescent MH - *Machine Learning MH - Female MH - Male MH - Nutrition Surveys MH - Risk Factors MH - United States/epidemiology PMC - PMC11762282 OTO - NOTNLM OT - Adolescents OT - Machine learning OT - Metabolic syndrome OT - NHANES OT - Predictive model COIS- Declarations. Competing interests: The authors declare that they have no competing interests. Ethics approval: All participants provided informed consent as part of the data collection process. The survey protocols were reviewed and approved by the National Center for Health Statistics (NCHS) Research Ethics Review Board. Since this study utilized de-identified secondary data, no additional ethics approval was required. The predictive model has been deployed on an online platform in strict compliance with data privacy and security regulations. The online tool does not collect or store user data, and all inputs are processed locally with encryption. The model is intended solely for educational and screening purposes and is not a formal diagnostic tool. Users are advised to consult healthcare professionals for further evaluation. Duplicate publication: This manuscript has not been submitted or published elsewhere in part or in full. EDAT- 2025/01/26 02:11 MHDA- 2025/01/26 02:12 PMCR- 2025/01/25 CRDT- 2025/01/25 23:21 PHST- 2024/10/29 00:00 [received] PHST- 2025/01/24 00:00 [accepted] PHST- 2025/01/26 02:12 [medline] PHST- 2025/01/26 02:11 [pubmed] PHST- 2025/01/25 23:21 [entrez] PHST- 2025/01/25 00:00 [pmc-release] AID - 10.1038/s41598-025-88156-4 [pii] AID - 88156 [pii] AID - 10.1038/s41598-025-88156-4 [doi] PST - epublish SO - Sci Rep. 2025 Jan 25;15(1):3274. doi: 10.1038/s41598-025-88156-4. PMID- 39862270 OWN - NLM STAT- MEDLINE DCOM- 20250503 LR - 20260715 IS - 1432-0711 (Electronic) IS - 0932-0067 (Print) IS - 0932-0067 (Linking) VI - 311 IP - 3 DP - 2025 Mar TI - Unmet clinical needs in women with polycystic ovary syndrome regarding fertility and obesity: a cross-sectional study from the patient's perspective. PG - 851-859 LID - 10.1007/s00404-024-07916-1 [doi] AB - PURPOSE: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, often leading to anovulatory infertility. Obesity exacerbates the reproductive, metabolic and psychological features of PCOS, making fertility treatment and patient satisfaction difficult. Despite guidelines from the European Society of Human Reproduction and Embryology (ESHRE) emphasizing lifestyle modifications and specific treatments, there remains a significant gap in adherence to these guidelines by both healthcare providers and patients. METHODS: A cross-sectional online survey was conducted from 1 January to 14 March 2021 among PCOS patients in Germany, Austria and Switzerland. A non-standardized, non-validated questionnaire covering several aspects of reproductive health was distributed via online channels. Data were analyzed using descriptive statistics, chi-squared tests, Student's t-tests and Jonckheere-Terpstra tests, with significance set at p < 0.05. RESULTS: Out of 2029 participants, 1902 completed the fertility questionnaire. Of these, 73.9% perceived their fertility to be impaired, with this perception being higher in obese women (80.8% vs. 67.4%, p < 0.001). The analysis focused on 564 childless women with a current desire to have children, 67.0% of whom met WHO criteria for infertility. Obese women (BMI >/= 30 kg/m(2)) reported lower satisfaction with fertility treatment (40.9 vs. 47.8, p = 0.009) and were less likely to receive fertility treatment (56.7% vs. 75.8%, p < 0.001). Despite recommendations, only 34.1% reported lifestyle changes as part of their treatment. Letrozole, the recommended first-line treatment, was underused (14.6%) and clomiphene citrate was more commonly prescribed (35.4%). Obese women reported fewer current pregnancies (4% vs. 13.9%, p < 0.001) and were more likely to be infertile for more than one year (77.0% vs. 53.0%, p < 0.001). They also expressed a greater desire for possibilities to ask more questions about PCOS and fertility and to undergo more infertility tests. (56.1% vs. 45.3%, p = 0.013; 69.4% vs. 59.8%, p = 0.020). CONCLUSIONS: Fertility management in PCOS patients, especially in obese patients, shows significant gaps in adherence to recommended guidelines, highlighting the need for improved patient education, professional training and individualized treatment strategies. Improved health care is essential to address reproductive concerns and improve outcomes in this population. CI - (c) 2025. The Author(s). FAU - Bachmann, Annette AU - Bachmann A AUID- ORCID: 0009-0003-5846-5994 AD - Division of Gynaecological Endocrinology and Reproductive Medicine, Department of Gynaecology and Obstetrics, University Hospital Frankfurt, Frankfurt, Germany. annette.bachmann@unimedizin-ffm.de. FAU - Weidlinger, Susanna AU - Weidlinger S AD - Division of Gynaecological Endocrinology and Reproductive Medicine, University Hospital Inselspital, Bern, Switzerland. FAU - von Wolff, Michael AU - von Wolff M AD - Division of Gynaecological Endocrinology and Reproductive Medicine, University Hospital Inselspital, Bern, Switzerland. FAU - Bitterlich, Norman AU - Bitterlich N AD - Goethe University Frankfurt: Goethe-Universitat Frankfurt am Main, Frankfurt, Germany. AD - Freelance, statistician, Chemnitz, Germany. FAU - Karn, Thomas AU - Karn T AD - Goethe University Frankfurt: Goethe-Universitat Frankfurt am Main, Frankfurt, Germany. FAU - Estermann, Julia AU - Estermann J AD - Faculty of medicine, University of Bern, Bern, Switzerland. FAU - Sourouni, Marina AU - Sourouni M AD - Department for Gynaecological Endocrinology and Fertility Disorders, University Hospital Heidelberg, Heidelberg, Germany. FAU - Stute, Petra AU - Stute P AD - Division of Gynaecological Endocrinology and Reproductive Medicine, University Hospital Inselspital, Bern, Switzerland. LA - eng PT - Journal Article DEP - 20250125 PL - Germany TA - Arch Gynecol Obstet JT - Archives of gynecology and obstetrics JID - 8710213 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - *Polycystic Ovary Syndrome/complications/psychology/therapy MH - Adult MH - *Obesity/complications/psychology MH - *Infertility, Female/etiology/therapy/psychology MH - Surveys and Questionnaires MH - Patient Satisfaction MH - Austria MH - Pregnancy MH - Germany MH - Young Adult MH - *Health Services Needs and Demand PMC - PMC11920305 OTO - NOTNLM OT - Gynecological care OT - Infertility OT - Obesity OT - Patient satisfaction OT - Polycystic ovary syndrome COIS- Declarations. Conflict of interest: The authors declare that no funds, grants, or other support were received during the preparation of this manuscript. The authors have no relevant financial or non-financial interests to disclose. Ethical approval: Ethical approval was granted by the Cantonal Ethics Committee Bern (Req-2020-00801) and Ethics Committee Goethe University Frankfurt. Both committees declared "not responsible" due to anonymous data collection. Informed consent: Patients agreed to anonymous data collection and analysis by filling in the questionnaire as approved by the ethical committees Bern, Switzerland and Frankfurt, Germany. EDAT- 2025/01/26 00:10 MHDA- 2025/03/18 18:22 PMCR- 2025/01/25 CRDT- 2025/01/25 11:13 PHST- 2024/09/21 00:00 [received] PHST- 2024/12/19 00:00 [accepted] PHST- 2025/03/18 18:22 [medline] PHST- 2025/01/26 00:10 [pubmed] PHST- 2025/01/25 11:13 [entrez] PHST- 2025/01/25 00:00 [pmc-release] AID - 10.1007/s00404-024-07916-1 [pii] AID - 7916 [pii] AID - 10.1007/s00404-024-07916-1 [doi] PST - ppublish SO - Arch Gynecol Obstet. 2025 Mar;311(3):851-859. doi: 10.1007/s00404-024-07916-1. Epub 2025 Jan 25. PMID- 39861399 OWN - NLM STAT- MEDLINE DCOM- 20250503 LR - 20260127 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 2 DP - 2025 Jan 13 TI - Impact of Maternal Macronutrient Intake on Large for Gestational Age Neonates' Risk Among Women with Gestational Diabetes Mellitus: Results from the Greek BORN2020 Cohort. LID - 10.3390/nu17020269 [doi] LID - 269 AB - BACKGROUND/OBJECTIVES: The effect of maternal macronutrient composition on the risk of large for gestational age (LGA) neonates among women with gestational diabetes mellitus (GDM) is not well understood. This study aimed to investigate these associations in a pregnant cohort in Northern Greece, considering both pre-pregnancy and early pregnancy dietary intake, and stratifying women by pre-pregnancy body mass index (BMI). METHODS: From a total of 797 eligible pregnant women, the 117 (14.7%) who developed GDM (and thus were included in the study) completed the validated Food Frequency Questionnaires (FFQs). Macronutrient intake was assessed for the six months before pregnancy and until mid-gestation, prior to the oral glucose tolerance test. Data were compared with European Food Safety Authority (EFSA) guidelines, and participants were stratified by pre-pregnancy BMI (normal vs. overweight/obese). Multivariate logistic regression was used to estimate adjusted odds ratios (aORs) for LGA risk. RESULTS: In normal-BMI women with GDM, higher dietary fiber (aOR = 1.39) and vegetable protein (aOR = 1.61) intake before pregnancy were both significantly associated with an increased risk of LGA. During early pregnancy, the elevated risk from vegetable protein persisted (aOR = 1.51). Among overweight/obese women, no significant pre-pregnancy associations were observed. However, during early pregnancy, a higher percentage of total carbohydrate intake was linked to increased LGA risk (aOR = 1.11), while maintaining saturated fatty acids "as low as possible" reduced the odds of LGA (aOR = 0.71). Elevated vegetable protein intake also increased LGA risk (aOR = 1.61). CONCLUSIONS: Maternal macronutrient intake prior to and during early pregnancy may influence LGA risk in GDM, with distinct patterns according to pre-pregnancy BMI. These findings underscore the importance of tailoring dietary recommendations-especially regarding fiber, vegetable protein, carbohydrates, and saturated fat-to mitigate the risk of LGA in women with GDM. FAU - Siargkas, Antonios AU - Siargkas A AUID- ORCID: 0000-0003-3066-9963 AD - 3rd Department of Obstetrics and Gynecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece. AD - Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece. FAU - Tranidou, Antigoni AU - Tranidou A AUID- ORCID: 0000-0001-6406-8424 AD - 3rd Department of Obstetrics and Gynecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece. AD - Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece. FAU - Magriplis, Emmanuela AU - Magriplis E AUID- ORCID: 0000-0001-6517-6857 AD - Department of Food Science and Human Nutrition, Agricultural University of Athens, Iera Odos 75, 118 55 Athens, Greece. FAU - Tsakiridis, Ioannis AU - Tsakiridis I AUID- ORCID: 0000-0003-4337-7871 AD - 3rd Department of Obstetrics and Gynecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece. FAU - Apostolopoulou, Aikaterini AU - Apostolopoulou A AUID- ORCID: 0000-0002-6391-3478 AD - Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece. FAU - Xenidis, Theodoros AU - Xenidis T AD - 3rd Department of Obstetrics and Gynecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece. FAU - Pazaras, Nikolaos AU - Pazaras N AD - Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece. FAU - Chourdakis, Michail AU - Chourdakis M AUID- ORCID: 0000-0002-9490-8356 AD - Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece. FAU - Dagklis, Themistoklis AU - Dagklis T AUID- ORCID: 0000-0002-2863-5839 AD - 3rd Department of Obstetrics and Gynecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece. LA - eng PT - Journal Article DEP - 20250113 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Nutrients) RN - 0 (Dietary Fiber) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Diabetes, Gestational/epidemiology MH - Greece/epidemiology MH - Adult MH - Body Mass Index MH - *Nutrients/administration & dosage MH - Infant, Newborn MH - *Maternal Nutritional Physiological Phenomena MH - *Diet/adverse effects MH - Risk Factors MH - *Fetal Macrosomia/etiology/epidemiology MH - Cohort Studies MH - Dietary Fiber/administration & dosage MH - Gestational Age PMC - PMC11767984 OTO - NOTNLM OT - GDM OT - LGA OT - carbohydrates OT - diet OT - fat OT - gestational diabetes mellitus OT - macronutrients OT - macrosomia OT - maternal OT - nutrition OT - pregnancy OT - protein COIS- The authors declare no conflicts of interest. EDAT- 2025/01/25 13:53 MHDA- 2025/01/25 13:54 PMCR- 2025/01/13 CRDT- 2025/01/25 01:27 PHST- 2024/12/04 00:00 [received] PHST- 2024/12/31 00:00 [revised] PHST- 2025/01/10 00:00 [accepted] PHST- 2025/01/25 13:54 [medline] PHST- 2025/01/25 13:53 [pubmed] PHST- 2025/01/25 01:27 [entrez] PHST- 2025/01/13 00:00 [pmc-release] AID - nu17020269 [pii] AID - nutrients-17-00269 [pii] AID - 10.3390/nu17020269 [doi] PST - epublish SO - Nutrients. 2025 Jan 13;17(2):269. doi: 10.3390/nu17020269. PMID- 39860951 OWN - NLM STAT- MEDLINE DCOM- 20250125 LR - 20250610 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 25 IP - 2 DP - 2025 Jan 20 TI - Normative Database of Spatiotemporal Gait Metrics Across Age Groups: An Observational Case-Control Study. LID - 10.3390/s25020581 [doi] LID - 581 AB - INTRODUCTION: Gait analysis is a vital tool in the assessment of human movement and has been widely used in clinical settings to identify potential abnormalities in individuals. However, there is a lack of consensus on the normative values for gait metrics in large populations. The primary objective of this study is to establish a normative database of spatiotemporal gait metrics across various age groups, contributing to a broader understanding of human gait dynamics. By doing so, we aim to enhance the clinical utility of gait analysis in diagnosing and managing health conditions. METHODS: We conducted an observational case-control study involving 313 healthy participants. The MetaMotionC IMU by Mbientlab Inc., equipped with a triaxial accelerometer, gyroscope, and magnetometer, was used to capture gait data. The IMU was placed at the sternal angle of each participant to ensure optimal data capture during a 50 m walk along a flat, unobstructed pathway. Data were collected through a Bluetooth connection to a smartphone running a custom-developed application and subsequently analysed using IMUGaitPY, a specialised version of the GaitPY Python package. RESULTS: The data showed that gait speeds decrease with ageing for males and females. The fastest gait speed is observed in the 41-50 age group at 1.35 +/- 0.23 m/s. Males consistently exhibit faster gait speeds than females across all age groups. Step length and cadence do not have clear trends with ageing. Gait speed and step length increase consistently with height, with the tallest group (191-200 cm) walking at an average speed of 1.49 +/- 0.12 m/s, with an average step length of 0.91 +/- 0.05 m. Cadence, however, decreases with increasing height, with the tallest group taking 103.52 +/- 5.04 steps/min on average. CONCLUSIONS: This study has established a comprehensive normative database for the spatiotemporal gait metrics of gait speed, step length, and cadence, highlighting the complexities of gait dynamics across age and sex groups and the influence of height. Our findings offer valuable reference points for clinicians to distinguish between healthy and pathological gait patterns, facilitating early detection and intervention for gait-related disorders. Moreover, this database enhances the clinical utility of gait analysis, supporting more objective diagnoses and assessments of therapeutic interventions. The normative database provides a valuable reference future research and clinical practice. It enables a more nuanced understanding of how gait evolves with age, gender, and physical stature, thus informing the development of targeted interventions to maintain mobility and prevent falls in older adults. Despite potential selection bias and the cross-sectional nature of the study, the insights gained provide a solid foundation for further longitudinal studies and diverse sampling to validate and expand upon these findings. FAU - Mobbs, Lianne AU - Mobbs L AUID- ORCID: 0000-0001-5955-0910 AD - Wearable and Gait Assessment Research (WAGAR) Group, Prince of Wales Private Hospital, Randwick, NSW 2031, Australia. AD - Faculty of Psychology, University of New South Wales (UNSW), Sydney, NSW 2033, Australia. FAU - Fernando, Vinuja AU - Fernando V AD - Wearable and Gait Assessment Research (WAGAR) Group, Prince of Wales Private Hospital, Randwick, NSW 2031, Australia. AD - NeuroSpine Surgery Research Group (NSURG), Sydney, NSW 2031, Australia. AD - Neuro Spine Clinic, Prince of Wales Private Hospital, 320-346 Barker St., Randwick, NSW 2031, Australia. AD - Faculty of Medicine, University of New South Wales (UNSW), Sydney, NSW 2033, Australia. FAU - Fonseka, R Dineth AU - Fonseka RD AUID- ORCID: 0000-0002-7748-5101 AD - Wearable and Gait Assessment Research (WAGAR) Group, Prince of Wales Private Hospital, Randwick, NSW 2031, Australia. AD - NeuroSpine Surgery Research Group (NSURG), Sydney, NSW 2031, Australia. AD - Neuro Spine Clinic, Prince of Wales Private Hospital, 320-346 Barker St., Randwick, NSW 2031, Australia. AD - Faculty of Medicine, University of New South Wales (UNSW), Sydney, NSW 2033, Australia. FAU - Natarajan, Pragadesh AU - Natarajan P AUID- ORCID: 0000-0002-7459-8805 AD - Wearable and Gait Assessment Research (WAGAR) Group, Prince of Wales Private Hospital, Randwick, NSW 2031, Australia. AD - NeuroSpine Surgery Research Group (NSURG), Sydney, NSW 2031, Australia. AD - Neuro Spine Clinic, Prince of Wales Private Hospital, 320-346 Barker St., Randwick, NSW 2031, Australia. AD - Faculty of Medicine, University of New South Wales (UNSW), Sydney, NSW 2033, Australia. FAU - Maharaj, Monish AU - Maharaj M AD - Wearable and Gait Assessment Research (WAGAR) Group, Prince of Wales Private Hospital, Randwick, NSW 2031, Australia. AD - NeuroSpine Surgery Research Group (NSURG), Sydney, NSW 2031, Australia. AD - Neuro Spine Clinic, Prince of Wales Private Hospital, 320-346 Barker St., Randwick, NSW 2031, Australia. AD - Faculty of Medicine, University of New South Wales (UNSW), Sydney, NSW 2033, Australia. FAU - Mobbs, Ralph J AU - Mobbs RJ AUID- ORCID: 0000-0001-6542-6836 AD - Wearable and Gait Assessment Research (WAGAR) Group, Prince of Wales Private Hospital, Randwick, NSW 2031, Australia. AD - NeuroSpine Surgery Research Group (NSURG), Sydney, NSW 2031, Australia. AD - Neuro Spine Clinic, Prince of Wales Private Hospital, 320-346 Barker St., Randwick, NSW 2031, Australia. AD - Faculty of Medicine, University of New South Wales (UNSW), Sydney, NSW 2033, Australia. LA - eng PT - Journal Article PT - Observational Study DEP - 20250120 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Middle Aged MH - *Gait/physiology MH - Case-Control Studies MH - Aged MH - *Gait Analysis/methods MH - Young Adult MH - Databases, Factual MH - Adolescent MH - Walking/physiology MH - Walking Speed/physiology MH - Accelerometry MH - Aging/physiology PMC - PMC11768510 OTO - NOTNLM OT - IMU OT - inertial measurement units OT - normative database OT - spatiotemporal gait analysis COIS- R.J.M. and all authors are members of the Wearable and Gait Assessment Research (WAGAR) Group, Sydney, Australia. None of the authors have any conflicts to declare with regard to this article. EDAT- 2025/01/25 13:52 MHDA- 2025/01/25 13:53 PMCR- 2025/01/20 CRDT- 2025/01/25 01:25 PHST- 2024/09/10 00:00 [received] PHST- 2025/01/11 00:00 [revised] PHST- 2025/01/16 00:00 [accepted] PHST- 2025/01/25 13:53 [medline] PHST- 2025/01/25 13:52 [pubmed] PHST- 2025/01/25 01:25 [entrez] PHST- 2025/01/20 00:00 [pmc-release] AID - s25020581 [pii] AID - sensors-25-00581 [pii] AID - 10.3390/s25020581 [doi] PST - epublish SO - Sensors (Basel). 2025 Jan 20;25(2):581. doi: 10.3390/s25020581. PMID- 39859013 OWN - NLM STAT- MEDLINE DCOM- 20250503 LR - 20250524 IS - 1648-9144 (Electronic) IS - 1010-660X (Print) IS - 1010-660X (Linking) VI - 61 IP - 1 DP - 2024 Dec 28 TI - Life Satisfaction Among Individuals with Physical Disabilities in Saudi Arabia: The Impact of Physical Activity, Self-Perceived Health and Fitness, and Sociodemographic Features. LID - 10.3390/medicina61010031 [doi] LID - 31 AB - Background and Objectives: Life satisfaction (LS) is a key aspect of mental well-being, particularly for individuals with physical disabilities (IWPDs).This study examined LS levels among IWPDs in Saudi Arabia, focusing on the effects of three independent variables: (i) sociodemographic factors, (ii) self-reported health and fitness, and (iii) self-assessed physical activity (PA). Materials and Methods: Data was collected from 271 participants using validated questionnaires. Two models analyzed the effects of the independent variables on LS: the first model included the overall level of PA, while the second examined its individual components. Results: The results indicated that females reported a higher LS than males (p = 0.011). Participants with a university degree demonstrated a significantly greater LS compared to those who did not disclose their educational status (Exp(beta) = 1.104). Poor health and inactivity were linked to a lower LS, while age correlated positively with LS (odds ratio = 1.012). Additional factors, including marital status, income, education level, and mobility assistance usage, significantly impacted LS. Interestingly, PA exhibited no direct statistical effect on LS. Conclusions: These findings highlight the importance of equitable access to education, regular PA, support for married couples, and preventive healthcare. Special attention to young people, particularly boys, is recommended to improve LS outcomes among IWPDs in Saudi Arabia. FAU - Alhumaid, Majed M AU - Alhumaid MM AUID- ORCID: 0000-0002-3829-4476 AD - Department of Physical Education, College of Education, King Faisal University, Al-Ahsa 31982, Saudi Arabia. FAU - Said, Mohamed A AU - Said MA AUID- ORCID: 0000-0003-4217-7122 AD - Department of Physical Education, College of Education, King Faisal University, Al-Ahsa 31982, Saudi Arabia. FAU - Khoo, Selina AU - Khoo S AUID- ORCID: 0000-0002-3090-9309 AD - Faculty of Sports and Exercise Science, Universiti Malaya, Kuala Lumpur 50603, Malaysia. LA - eng GR - KFU241411/King Faisal University/ PT - Journal Article DEP - 20241228 PL - Switzerland TA - Medicina (Kaunas) JT - Medicina (Kaunas, Lithuania) JID - 9425208 SB - IM MH - Humans MH - Male MH - Female MH - Saudi Arabia MH - *Persons with Disabilities/psychology/statistics & numerical data MH - Adult MH - *Personal Satisfaction MH - *Exercise/psychology MH - Middle Aged MH - Surveys and Questionnaires MH - Sociodemographic Factors MH - Socioeconomic Factors MH - *Physical Fitness/psychology MH - Health Status MH - Adolescent MH - Self Report MH - Cross-Sectional Studies PMC - PMC11766455 OTO - NOTNLM OT - life satisfaction OT - physical activity OT - physical disabilities OT - sociodemographics OT - well-being COIS- The authors declare no conflicts of interest. The funder had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2025/01/25 13:54 MHDA- 2025/01/25 13:55 PMCR- 2024/12/28 CRDT- 2025/01/25 01:14 PHST- 2024/11/23 00:00 [received] PHST- 2024/12/20 00:00 [revised] PHST- 2024/12/27 00:00 [accepted] PHST- 2025/01/25 13:55 [medline] PHST- 2025/01/25 13:54 [pubmed] PHST- 2025/01/25 01:14 [entrez] PHST- 2024/12/28 00:00 [pmc-release] AID - medicina61010031 [pii] AID - medicina-61-00031 [pii] AID - 10.3390/medicina61010031 [doi] PST - epublish SO - Medicina (Kaunas). 2024 Dec 28;61(1):31. doi: 10.3390/medicina61010031. PMID- 39857931 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250130 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 1 DP - 2025 Jan 16 TI - Design, Content and Ecological Validity and Reliability of the Physical Activity and Sport Habits Questionnaire for Children Aged 8-12 Years in the Province of Gipuzkoa (Spain). LID - 10.3390/children12010100 [doi] LID - 100 AB - Background/Objectives: This study aimed to develop a questionnaire to describe and diagnose the physical activity and sport (PAS) habits of 8-12-year-old schoolchildren, assessing its content, ecological validity and reliability, from a multidimensional perspective aligned with Global Matrix 4.0 indicators. Methods: The questionnaire design phase involved seven individuals from the university sector and sport managers from the Gipuzkoa Provincial Council. Seventeen experts later evaluated the questionnaire's content and ecological validity. For reliability testing, 276 schoolchildren aged 8 to 12 completed the questionnaire twice, with a time interval of two weeks to two months. Statistical analyses included the Wilcoxon test to compare expert ratings, effect size and percentage change calculations for magnitude assessment, and McNemar, McN-Bowker or Wilcoxon tests to compare differences between initial and repeat responses. Cohen's Kappa was used to assess agreement. Results: The initial battery of items, submitted to the validation process, comprised 31 items across 10 dimensions, derived from validated questionnaires and published works. Following content and ecological validity evaluations, modifications were made and nine items were removed due to improved wording, clarification of concepts, redundancy or lack of relevance. Expert quantitative analyses indicated improved overall questionnaire values. Reliability analysis revealed significant differences in five of the twenty-two items, though substantial agreement (from slight to almost perfect) was observed in twenty items. Conclusions: The study confirmed the questionnaire's validity and reliability as a suitable tool for assessing PAS practices among 8-12-year-old schoolchildren in Gipuzkoa, Spain, in both Basque and Spanish languages. FAU - Badiola-Lekue, Aduna AU - Badiola-Lekue A AUID- ORCID: 0000-0003-3682-8187 AD - Research Group in Physical Activity, Physical Exercise and Sport (AKTIBOki) and Society, Sport and Physical Activity (GIKAFIT) Research Group, Department of Physical Education and Sports, Faculty of Education and Sport, University of the Basque Country (UPV/EHU), 01007 Vitoria-Gasteiz, Spain. FAU - Ibanez, Irantzu AU - Ibanez I AUID- ORCID: 0000-0001-8266-3737 AD - Research Group in Physical Activity, Physical Exercise and Sport (AKTIBOki) and Society, Sport and Physical Activity (GIKAFIT) Research Group, Department of Didactics of Musical, Plastic and Corporal Expression, Faculty of Education and Sport, University of the Basque Country (UPV/EHU), 01007 Vitoria-Gasteiz, Spain. FAU - Fuentes, Maite AU - Fuentes M AD - Department of Physical Education and Sports, Faculty of Education and Sport, University of the Basque Country (UPV/EHU), 01007 Vitoria-Gasteiz, Spain. FAU - Yanci, Javier AU - Yanci J AUID- ORCID: 0000-0002-8965-5024 AD - Research Group in Physical Activity, Physical Exercise and Sport (AKTIBOki) and Society, Sport and Physical Activity (GIKAFIT) Research Group, Department of Physical Education and Sports, Faculty of Education and Sport, University of the Basque Country (UPV/EHU), 01007 Vitoria-Gasteiz, Spain. FAU - Usabiaga, Oidui AU - Usabiaga O AUID- ORCID: 0000-0003-1935-8961 AD - Research Group in Physical Activity, Physical Exercise and Sport (AKTIBOki) and Society, Sport and Physical Activity (GIKAFIT) Research Group, Department of Physical Education and Sports, Faculty of Education and Sport, University of the Basque Country (UPV/EHU), 01007 Vitoria-Gasteiz, Spain. FAU - Iturricastillo, Aitor AU - Iturricastillo A AUID- ORCID: 0000-0001-7004-5341 AD - Research Group in Physical Activity, Physical Exercise and Sport (AKTIBOki) and Society, Sport and Physical Activity (GIKAFIT) Research Group, Department of Physical Education and Sports, Faculty of Education and Sport, University of the Basque Country (UPV/EHU), 01007 Vitoria-Gasteiz, Spain. LA - eng PT - Journal Article DEP - 20250116 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC11764041 OTO - NOTNLM OT - education OT - extracurricular sport OT - healthy habits OT - physical activity OT - primary OT - sport habits COIS- The authors declare no conflicts of interest. EDAT- 2025/01/25 13:53 MHDA- 2025/01/25 13:54 PMCR- 2025/01/16 CRDT- 2025/01/25 01:08 PHST- 2024/11/29 00:00 [received] PHST- 2025/01/04 00:00 [revised] PHST- 2025/01/14 00:00 [accepted] PHST- 2025/01/25 13:54 [medline] PHST- 2025/01/25 13:53 [pubmed] PHST- 2025/01/25 01:08 [entrez] PHST- 2025/01/16 00:00 [pmc-release] AID - children12010100 [pii] AID - children-12-00100 [pii] AID - 10.3390/children12010100 [doi] PST - epublish SO - Children (Basel). 2025 Jan 16;12(1):100. doi: 10.3390/children12010100. PMID- 39854524 OWN - NLM STAT- MEDLINE DCOM- 20250124 LR - 20260921 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 1 DP - 2025 TI - Psychometric validation of the Cystic Fibrosis Impact Questionnaire (CF-IQ): A patient-reported outcome assessing impacts of cystic fibrosis. PG - e0317775 LID - 10.1371/journal.pone.0317775 [doi] LID - e0317775 AB - The Cystic Fibrosis (CF) Impact Questionnaire (CF-IQ) was qualitatively developed to assess the impact of CF in the context of treatment advancements and increased longevity. This study reports the CF-IQ validation. In this noninterventional validation study, people with CF completed the 40-item CF-IQ and validating patient-reported outcome measures (PROMs) via electronic diaries at enrollment (baseline) and at the 4-week follow-up. Validation consisted of modern methods and focus groups to finalize structural validity, and classical methods to assess internal consistency [1-3], test-retest reliability [4,5], concurrent validity [5], and known-groups validity [5] of the CF-IQ. At baseline, 214 adults completed the survey; 193 completed the follow-up survey. Unidimensional item response theory (IRT) models were separately fit to 5 prespecified domains (Control and Burden of CF Treatment Impacts, Physical Activity Impacts, Social Activity Impacts, Emotional Impacts, and Work/School Limitation Impacts). IRT local dependence (LD) statistics identified 17 redundant items. Two independent CF-patient focus groups (14 total patients) confirmed these findings, and the 17 items were dropped. Each domain defined on the final 23 items achieved the criterion of exact model fit as measured by the root mean squared error of approximation (RMSEA, values = 0), Internal consistency (Cronbach's alpha) values ranged from 0.81 to 0.89, 4 of 5 domains achieved acceptable test-retest reliability, with intraclass correlation coefficient (ICC) values >/= 0.7, acceptable concurrent validity was achieved for all domains, and known-groups validity was established. The novel CF-IQ is a psychometrically robust PROM capturing patient-centric impacts of CF in the context of the current standard of care. CI - Copyright: (c) 2025 Serrano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Serrano, Daniel AU - Serrano D AUID- ORCID: 0009-0007-6018-1367 AD - Pharmerit International-An OPEN Health Company, Bethesda, MD, United States of America. AD - The Psychometrics Team, Sheridan, WY, United States of America. FAU - Uzumcu, Alyssa AU - Uzumcu A AD - Pharmerit International-An OPEN Health Company, Bethesda, MD, United States of America. FAU - Gerstein, Maya AU - Gerstein M AD - Pharmerit International-An OPEN Health Company, Bethesda, MD, United States of America. FAU - Ayasse, Nicolai D AU - Ayasse ND AUID- ORCID: 0000-0003-0890-7742 AD - Pharmerit International-An OPEN Health Company, Bethesda, MD, United States of America. FAU - Engstrom, Ella AU - Engstrom E AD - Pharmerit International-An OPEN Health Company, Bethesda, MD, United States of America. FAU - Barnes, Frederick B AU - Barnes FB AD - Pharmerit International-An OPEN Health Company, Bethesda, MD, United States of America. FAU - Iaconangelo, Charles AU - Iaconangelo C AD - Pharmerit International-An OPEN Health Company, Bethesda, MD, United States of America. FAU - Thorat, Teja AU - Thorat T AD - Vertex Pharmaceuticals Incorporated, Boston, MA, United States of America. FAU - McGarry, Lisa J AU - McGarry LJ AD - Vertex Pharmaceuticals Incorporated, Boston, MA, United States of America. FAU - Sermet-Gaudelus, Isabelle AU - Sermet-Gaudelus I AD - INSERM U1151, Universite Paris Cite, Centre de References Maladies Rares Mucoviscidose et Maladies Apparentees, Hopital Necker Enfants Malades, Paris, France. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250124 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Cystic Fibrosis/psychology MH - Male MH - Female MH - *Patient Reported Outcome Measures MH - *Psychometrics/methods MH - Adult MH - Surveys and Questionnaires MH - Middle Aged MH - Reproducibility of Results MH - Young Adult MH - Quality of Life MH - Adolescent MH - Focus Groups PMC - PMC11761112 COIS- I have read the journal's policy and the authors of this manuscript have the following competing interests: DS, AU, MG, NDA, EE, FBB, and CI were employees of Pharmerit International - An OPEN Health Company, which received funding from Vertex Pharmaceuticals, Inc. CI is currently an employee of Janssen Global Services, LLC. TT and LJM are employees of, receive salary from, and may own stock or stock options of Vertex Pharmaceuticals, Inc. ISG is on the faculty at and receives salary from Institut Necker-Enfants Malades Hospital, Paris, France; she has participated as a principal investigator on clinical studies for Vertex Pharmaceuticals, Inc. EDAT- 2025/01/24 18:25 MHDA- 2025/01/24 18:26 PMCR- 2025/01/24 CRDT- 2025/01/24 14:13 PHST- 2024/03/08 00:00 [received] PHST- 2025/01/03 00:00 [accepted] PHST- 2025/01/24 18:26 [medline] PHST- 2025/01/24 18:25 [pubmed] PHST- 2025/01/24 14:13 [entrez] PHST- 2025/01/24 00:00 [pmc-release] AID - PONE-D-24-03301 [pii] AID - 10.1371/journal.pone.0317775 [doi] PST - epublish SO - PLoS One. 2025 Jan 24;20(1):e0317775. doi: 10.1371/journal.pone.0317775. eCollection 2025. PMID- 39854338 OWN - NLM STAT- MEDLINE DCOM- 20250503 LR - 20260917 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 1 DP - 2025 TI - Low-cost and scalable machine learning model for identifying children and adolescents with poor oral health using survey data: An empirical study in Portugal. PG - e0312075 LID - 10.1371/journal.pone.0312075 [doi] LID - e0312075 AB - This empirical study assessed the potential of developing a machine-learning model to identify children and adolescents with poor oral health using only self-reported survey data. Such a model could enable scalable and cost-effective screening and targeted interventions, optimizing limited resources to improve oral health outcomes. To train and test the model, we used data from 2,133 students attending schools in a Portuguese municipality. Poor oral health (the dependent variable) was defined as having a Decayed, Missing, and Filled Teeth index for deciduous teeth (dmft) or permanent teeth (DMFT) above expert-defined thresholds (dmft/DMFT >/= 3 or 4). The survey provided information about the students' oral health habits, knowledge, beliefs, and food and physical activity habits, which served as independent variables. Logistic regression models with variables selected through low-variance filtering and recursive feature elimination outperformed various others trained with complex machine learning algorithms based on precision@k metric, outperforming also random selection and expert rule-based models in identifying students with poor oral health. The proposed models are inherently explainable, broadly applicable, which given the context, could compensate their lower performance (Area Under the Curve = 0.64-0.70) compared to similar approaches and models. This study is one of the few in oral health care that includes bias auditing of classification models. The audit surfaced potential biases related to demographic factors such as age and social assistance status. Addressing these biases without significantly compromising model performance remains a challenge. The results confirm the feasibility of survey-based machine learning models for identifying individuals with poor oral health, but further validation of this approach and pilot testing in field trials are necessary. CI - Copyright: (c) 2025 Lavado et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Lavado, Susana AU - Lavado S AUID- ORCID: 0000-0002-1088-6357 AD - Nova School of Business and Economics, Universidade Nova de Lisboa, Carcavelos, Portugal. FAU - Costa, Eduardo AU - Costa E AUID- ORCID: 0000-0002-4347-6338 AD - CEGIST - Centre for Management Studies, Instituto Superior Tecnico, Universidade de Lisboa, Carcavelos, Portugal. FAU - Sturm, Niclas F AU - Sturm NF AUID- ORCID: 0000-0002-2070-844X AD - Nova School of Information Management, Universidade Nova de Lisboa, Carcavelos, Portugal. FAU - Tafferner, Johannes S AU - Tafferner JS AUID- ORCID: 0009-0002-8470-3872 AD - Nova School of Business and Economics, Universidade Nova de Lisboa, Carcavelos, Portugal. FAU - Rodrigues, Octavio AU - Rodrigues O AD - Associacao Portuguesa Promotora de Saude e Higiene Oral, Seixal, Portugal. FAU - Pita Barros, Pedro AU - Pita Barros P AD - Nova School of Business and Economics, Universidade Nova de Lisboa, Carcavelos, Portugal. FAU - Zejnilovic, Leid AU - Zejnilovic L AD - Nova School of Business and Economics, Universidade Nova de Lisboa, Carcavelos, Portugal. LA - eng SI - figshare/25847044.v1 PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250124 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Oral Health/statistics & numerical data MH - *Machine Learning MH - Adolescent MH - Child MH - Male MH - Female MH - Portugal/epidemiology MH - Dental Caries/epidemiology MH - Surveys and Questionnaires PMC - PMC11759376 COIS- The authors have declared that no competing interests exist. EDAT- 2025/01/24 18:25 MHDA- 2025/01/24 18:26 PMCR- 2025/01/24 CRDT- 2025/01/24 13:42 PHST- 2024/03/13 00:00 [received] PHST- 2024/09/30 00:00 [accepted] PHST- 2025/01/24 18:26 [medline] PHST- 2025/01/24 18:25 [pubmed] PHST- 2025/01/24 13:42 [entrez] PHST- 2025/01/24 00:00 [pmc-release] AID - PONE-D-24-08250 [pii] AID - 10.1371/journal.pone.0312075 [doi] PST - epublish SO - PLoS One. 2025 Jan 24;20(1):e0312075. doi: 10.1371/journal.pone.0312075. eCollection 2025. PMID- 39854325 OWN - NLM STAT- MEDLINE DCOM- 20250502 LR - 20260921 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 1 DP - 2025 TI - A missing link: The interdependence between sugar-sweetened beverage and cigarette consumption from China. PG - e0316891 LID - 10.1371/journal.pone.0316891 [doi] LID - e0316891 AB - Sugar-sweetened beverages (SSBs) and cigarettes are addictive substances and addictive substances are often related in consumption with each other. However, the potential interdependence between SSB and cigarette consumption has not been explored in the literature. As SSB and cigarette consumption have posed a great threat to individual health, the knowledge of such interdependence is critical for policymakers to design and coordinate government interventions. We thus employed Heckman sample selection model and simultaneous equation model to identify and validate the interdependence between SSB and cigarette consumption across subgroups exhibiting different smoking behaviors with individual-level data from the China Health and Nutrition Survey (CHNS) during the period from 2004 to 2011. We find that SSBs and cigarettes are complements in that individuals who ever smoked are more likely to consume SSBs frequently with higher level of SSB intake eventually and SSB intake of current smokers increases along with the amount of cigarettes smoked. SSBs and cigarettes are also substitutes in that former smokers are more likely to consume SSBs compared with current smokers. The complementary relation observed among current smokers implies that government interventions targeting one of the two goods may yield a double dividend effect on health whereas the substitutable relation displayed by former smokers suggests that the health effect of interventions designed to reduce the consumption of one good may be tempered by an elevated demand for the other. CI - Copyright: (c) 2025 Liu, Chen. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Liu, Lu AU - Liu L AD - Institute of Agricultural Economics and Development, Chinese Academy of Agricultural Sciences, Beijing, China. FAU - Chen, Kevin AU - Chen K AUID- ORCID: 0000-0002-1343-8496 AD - China Academy for Rural Development, Zhejiang University, Hangzhou, Zhejiang, China. AD - International Food Policy Research Institute, East and Central Asia Office, Beijing, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250124 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - China/epidemiology MH - *Sugar-Sweetened Beverages/statistics & numerical data/adverse effects MH - Male MH - Adult MH - Female MH - *Tobacco Products/statistics & numerical data MH - Middle Aged MH - *Cigarette Smoking/epidemiology MH - Young Adult MH - Nutrition Surveys MH - Adolescent MH - *Smoking/epidemiology PMC - PMC11760568 COIS- The authors have declared that no competing interests exist. EDAT- 2025/01/24 18:25 MHDA- 2025/01/24 18:26 PMCR- 2025/01/24 CRDT- 2025/01/24 13:34 PHST- 2024/03/23 00:00 [received] PHST- 2024/12/18 00:00 [accepted] PHST- 2025/01/24 18:26 [medline] PHST- 2025/01/24 18:25 [pubmed] PHST- 2025/01/24 13:34 [entrez] PHST- 2025/01/24 00:00 [pmc-release] AID - PONE-D-24-11354 [pii] AID - 10.1371/journal.pone.0316891 [doi] PST - epublish SO - PLoS One. 2025 Jan 24;20(1):e0316891. doi: 10.1371/journal.pone.0316891. eCollection 2025. PMID- 39854294 OWN - NLM STAT- MEDLINE DCOM- 20250503 LR - 20260921 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 1 DP - 2025 TI - The measurement reliability and equivalence of print versus online versions of the Youth Activity Profile. PG - e0312254 LID - 10.1371/journal.pone.0312254 [doi] LID - e0312254 AB - PURPOSE: The Youth Activity Profile (YAP) is a 7-day self-report designed to quantify physical activity and sedentary behaviors among youth. This study evaluated the reliability of the online version of the YAP and equivalence with the paper-based version. METHOD: A total of 2,490 participants from 17 schools in Iowa and Texas completed the YAP. Each classroom was randomly assigned to complete either the print or online version twice. A variance components model was used to assess the test-retest reliability and equivalence testing was also applied. RESULTS: Both paper and online versions had similar reliability for the PA estimates in school (ICCprint = 0.69-0.91; ICConline = 0.54-0.84), at home (ICCprint = 0.72-0.83; ICConline = 0.64-0.94), PA at weekend (ICCprint = 0.33-0.72; ICConline = 0.39-0.70), and SB (ICCprint = 0.69-0.90; ICConline = 0.66-0.80). The two versions were statistically equivalent for most YAP items except for recess. CONCLUSION: The online YAP appears to be a reliable assessment of physical activity and sedentary behavior in youth populations. CI - Copyright: (c) 2025 Bai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Bai, Yang AU - Bai Y AD - Department of Health and Kinesiology, University of Utah, Salt Lake City, Utah, United States of America. FAU - Dixon, Philip M AU - Dixon PM AD - Department of Statistics, Iowa State University, Ames, Iowa, United States of America. FAU - Saint-Maurice, Pedro F AU - Saint-Maurice PF AD - Champalimaud Foundation, Lisbon, Portugal. FAU - Hibbing, Paul R AU - Hibbing PR AUID- ORCID: 0000-0002-1469-5160 AD - Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, Illinois, United States of America. FAU - McLoughlin, Gabriella M AU - McLoughlin GM AD - Department of Social and Behavioral Sciences, Temple University, Philadelphia, Pennsylvania, United States of America. FAU - da Silva, Michael Pereira AU - da Silva MP AUID- ORCID: 0000-0002-7628-3997 AD - Faculty of Medicine, Federal University of Rio Grande, Rio Grande, Rio Grande do Sul, Brazil. FAU - Welk, Gregory J AU - Welk GJ AUID- ORCID: 0000-0001-7132-9725 AD - Department of Kinesiology, Iowa State University, Ames, Iowa, United States of America. LA - eng GR - R21 CA188641/CA/NCI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20250124 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Male MH - Female MH - Adolescent MH - Reproducibility of Results MH - Child MH - Sedentary Behavior MH - Self Report MH - *Internet MH - *Exercise MH - *Motor Activity MH - Texas MH - Iowa PMC - PMC11760011 COIS- The authors have declared that no competing interests exist. EDAT- 2025/01/24 18:25 MHDA- 2025/01/24 18:26 PMCR- 2025/01/24 CRDT- 2025/01/24 13:33 PHST- 2023/01/06 00:00 [received] PHST- 2024/10/03 00:00 [accepted] PHST- 2025/01/24 18:26 [medline] PHST- 2025/01/24 18:25 [pubmed] PHST- 2025/01/24 13:33 [entrez] PHST- 2025/01/24 00:00 [pmc-release] AID - PONE-D-23-00297 [pii] AID - 10.1371/journal.pone.0312254 [doi] PST - epublish SO - PLoS One. 2025 Jan 24;20(1):e0312254. doi: 10.1371/journal.pone.0312254. eCollection 2025. PMID- 39849621 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250129 IS - 2052-1847 (Print) IS - 2052-1847 (Electronic) IS - 2052-1847 (Linking) VI - 17 IP - 1 DP - 2025 Jan 23 TI - Remote assessment of physical fitness via videoconferencing: a systematic review. PG - 11 LID - 10.1186/s13102-024-01050-w [doi] LID - 11 AB - Physical fitness is a critical marker of overall health across all age groups, influencing longevity and quality of life. This systematic review assessed the use of remote physical fitness assessments, a crucial adaptation during the COVID-19 pandemic that broadened access to health monitoring outside traditional settings. The review included 35 studies, covering various age groups and health conditions, and evaluated 48 physical fitness tests across eight physical fitness components. Balance, muscular strength, and endurance were the most frequently assessed, with tests like the 30-second sit-to-stand (30s-STS) showing strong validity, reliability, and feasibility for remote use. However, the study population was mainly adults and older adults, with nearly no focus on children, revealing a significant gap in research for younger populations. Additionally, the review identified gaps in assessing components such as body composition, reaction time, and agility, which are crucial for a comprehensive assessment of physical fitness. These gaps underscore the need for further research and development of reliable and valid remote assessment tools. The findings of this review emphasize the importance of standardizing remote physical fitness assessments to ensure their validity, reliability, and feasibility making them effective tools for health monitoring across diverse populations and settings. CI - (c) 2025. The Author(s). FAU - Klein, Thorsten AU - Klein T AD - Institute of Movement and Sport, Karlsruhe University of Education, Bismarckstrasse 10, 76133, Karlsruhe, Germany. thorsten.klein@ph-karlsruhe.de. FAU - Worth, Annette AU - Worth A AD - Institute of Movement and Sport, Karlsruhe University of Education, Bismarckstrasse 10, 76133, Karlsruhe, Germany. FAU - Niessner, Claudia AU - Niessner C AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Kaiserstrasse 12, 76131, Karlsruhe, Germany. FAU - Hanssen-Doose, Anke AU - Hanssen-Doose A AD - Institute of Movement and Sport, Karlsruhe University of Education, Bismarckstrasse 10, 76133, Karlsruhe, Germany. LA - eng GR - 01UP2222/German Federal Ministry of Education and Research/ GR - 01UP2222/German Federal Ministry of Education and Research/ GR - 01UP2222/German Federal Ministry of Education and Research/ GR - 01UP2222/German Federal Ministry of Education and Research/ PT - Journal Article DEP - 20250123 PL - England TA - BMC Sports Sci Med Rehabil JT - BMC sports science, medicine & rehabilitation JID - 101605016 PMC - PMC11756083 COIS- Declarations. Ethics approval and consent to participate: Ethics approval is not required for this systematic review as it involves the analysis of published data and does not include direct interaction with human or animal subjects. All data analysed in this review are derived from previously conducted studies that have obtained their respective ethical approvals. Consent for publication: Not applicable. This systematic review does not contain any data that could be linked to individual participants or require consent for publication. Competing interests: The authors declare no competing interests. EDAT- 2025/01/24 06:26 MHDA- 2025/01/24 06:27 PMCR- 2025/01/23 CRDT- 2025/01/24 00:34 PHST- 2024/11/01 00:00 [received] PHST- 2024/12/30 00:00 [accepted] PHST- 2025/01/24 06:27 [medline] PHST- 2025/01/24 06:26 [pubmed] PHST- 2025/01/24 00:34 [entrez] PHST- 2025/01/23 00:00 [pmc-release] AID - 10.1186/s13102-024-01050-w [pii] AID - 1050 [pii] AID - 10.1186/s13102-024-01050-w [doi] PST - epublish SO - BMC Sports Sci Med Rehabil. 2025 Jan 23;17(1):11. doi: 10.1186/s13102-024-01050-w. PMID- 39847886 OWN - NLM STAT- MEDLINE DCOM- 20250215 LR - 20260309 IS - 1872-6232 (Electronic) IS - 0378-3782 (Linking) VI - 201 DP - 2025 Feb TI - Validation the modified subjective global nutrition assessment (mSGNA) for assessing malnutrition among hospitalized children. PG - 106201 LID - S0378-3782(25)00011-8 [pii] LID - 10.1016/j.earlhumdev.2025.106201 [doi] AB - OBJECTIVES: To validate a modified Subjective Global Nutritional Assessment (mSGNA) for assessing nutritional status among Vietnamese children. STUDY DESIGN: A cross-sectional study was conducted at the National Children's Hospital in Vietnam, where 200 children were assessed using mSGNA, Subjective Global Nutritional Assessment (SGNA), and a standardized method developed by the Academy of Nutrition and Dietetics (AND) and the American Society for Parenteral and Enteral Nutrition (ASPEN). RESULTS: The mSGNA showed high accuracy with 82.9 % sensitivity and 90.8 % specificity when compared to SGNA, and moderate accuracy (72.0 % sensitivity, 77.3 % specificity) against AND/ASPEN. The kappa value for mSGNA-SGNA agreement was 0.8 (95 % CI 0.686-0.849), indicating substantial agreement, while the kappa value for mSGNA-AND/ASPEN agreement was 0.5 (95%CI 0.304-0.567), reflecting moderate agreement. CONCLUSIONS: The results suggest that mSGNA is a reliable tool for identifying malnutrition in Vietnamese pediatric patients, with high sensitivity and specificity in comparison to SGNA and moderate effectiveness against AND/ASPEN standards. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Nguyen, Thi Thu Lieu AU - Nguyen TTL AD - Hanoi Medical University, 1 Ton That Tung, Dong Da, Hanoi 100000, Viet Nam; National Hospital of Obstetrics and Gynecology, 43 Trang Thi, Hoan Kiem, Hanoi 100000, Viet Nam. Electronic address: nguyenthithulieu@ipmph.edu.vn. FAU - Than, Thi Mai Anh AU - Than TMA AD - Hanoi Medical University, 1 Ton That Tung, Dong Da, Hanoi 100000, Viet Nam. FAU - Nguyen, Ha Anh AU - Nguyen HA AD - Hanoi Medical University, 1 Ton That Tung, Dong Da, Hanoi 100000, Viet Nam. FAU - Doan, Thu Huyen AU - Doan TH AD - Hanoi Medical University, 1 Ton That Tung, Dong Da, Hanoi 100000, Viet Nam. FAU - Le, Thi Thanh Xuan AU - Le TTX AD - Hanoi Medical University, 1 Ton That Tung, Dong Da, Hanoi 100000, Viet Nam. Electronic address: lethithanhxuan@hmu.edu.vn. FAU - Le, Thi Huong AU - Le TH AD - Hanoi Medical University, 1 Ton That Tung, Dong Da, Hanoi 100000, Viet Nam. Electronic address: lethihuong@hmu.edu.vn. FAU - Luu, Thi My Thuc AU - Luu TMT AD - Viet Nam National Children's Hospital, 18/879 La Thanh, Dong Da, Hanoi 100000, Viet Nam. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250116 PL - Ireland TA - Early Hum Dev JT - Early human development JID - 7708381 SB - IM MH - Humans MH - *Nutrition Assessment MH - Child, Preschool MH - Female MH - Male MH - Infant MH - Cross-Sectional Studies MH - *Malnutrition/diagnosis MH - *Child, Hospitalized MH - Child MH - Vietnam MH - Nutritional Status MH - Sensitivity and Specificity OTO - NOTNLM OT - Hospitalized children OT - Malnutrition OT - Nutritional status OT - The modifed SGNA OT - Validation COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/01/24 00:26 MHDA- 2025/02/16 01:32 CRDT- 2025/01/23 18:04 PHST- 2024/11/04 00:00 [received] PHST- 2025/01/14 00:00 [revised] PHST- 2025/01/15 00:00 [accepted] PHST- 2025/02/16 01:32 [medline] PHST- 2025/01/24 00:26 [pubmed] PHST- 2025/01/23 18:04 [entrez] AID - S0378-3782(25)00011-8 [pii] AID - 10.1016/j.earlhumdev.2025.106201 [doi] PST - ppublish SO - Early Hum Dev. 2025 Feb;201:106201. doi: 10.1016/j.earlhumdev.2025.106201. Epub 2025 Jan 16. PMID- 39846270 OWN - NLM STAT- MEDLINE DCOM- 20250415 LR - 20260828 IS - 1471-0528 (Electronic) IS - 1470-0328 (Print) IS - 1470-0328 (Linking) VI - 132 IP - Suppl 2 DP - 2025 Apr TI - Impact of Laser-Assisted Hatching on Cognitive and Metabolic Development of Singletons Conceived Through Frozen-Thawed Embryo Transfer: A Matched Cohort Study. PG - 18-25 LID - 10.1111/1471-0528.18047 [doi] AB - OBJECTIVE: This study aimed to examine the impact of laser-assisted hatching (LAH) on the physical, metabolic, cognitive and behavioural profiles of singletons conceived through frozen-thawed embryo transfer (FET) at the preschool age. DESIGN: A matched cohort study. SETTING: The reproductive centre of Women's Hospital, Zhejiang University School of Medicine. POPULATION: Singletons born to couples with infertility who underwent FET cycles with or without LAH treatment from 2016 to 2019 and were followed up till age 4-6 years in 2023. METHODS: Cognitive and behavioural development was evaluated at the preschool age using the Wechsler Preschool and Primary Scale of Intelligence, Fourth Edition (WPPSI-IV) and the Adaptive Behavior Assessment System, Second Edition (ABAS-II). Statistical analysis was performed using moderated multiple linear regression. MAIN OUTCOME MEASURES: The full-scale intelligence quotient (FSIQ) and general adaptive composite (GAI). RESULTS: In total, 120 pairs of mother and child were included in the analysis. No significant differences in age, sex, height, weight, body mass index, blood pressure, thyroid function and metabolic indicators were observed between the two groups. After adjusting for demographics and socioeconomic status, LAH singletons showed FSIQ and GAI scores similar to those of non-LAH singletons. CONCLUSIONS: At 4-6 years of age, the cognitive, metabolic and physical developmental outcomes of preschool children born after LAH treatment were comparable with those of the non-LAH group, indicating that LAH may be considered a safe assisted reproductive technology method. However, further longer and regular follow-ups are needed to validate the findings of this study. CI - (c) 2025 The Author(s). BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd. FAU - Liu, Xin-Yi AU - Liu XY AD - Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, China. FAU - Zhang, Chun-Xi AU - Zhang CX AD - Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, China. FAU - Chen, Jian-Peng AU - Chen JP AD - Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, China. FAU - Liang, Qi AU - Liang Q AD - Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, China. FAU - Wu, Yi-Qing AU - Wu YQ AD - Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, China. FAU - Xue, Jing-Lei AU - Xue JL AD - Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, China. FAU - Li, Ling-Hui AU - Li LH AD - Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, China. FAU - Xu, Qi-Qi AU - Xu QQ AD - Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, China. FAU - Zhang, Fang-Hong AU - Zhang FH AD - Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, China. FAU - Yang, Ying-Zhi AU - Yang YZ AD - Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, China. FAU - Wang, Yue-Mei AU - Wang YM AD - Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, China. FAU - Liu, Yi-Feng AU - Liu YF AD - Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, China. AD - Zhejiang Provincial Clinical Research Center for Child Health, Hangzhou, China. FAU - Zhang, Dan AU - Zhang D AD - Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, China. AD - Zhejiang Provincial Clinical Research Center for Child Health, Hangzhou, China. LA - eng SI - ClinicalTrials.gov/ChiCTR2300071711 GR - National Key Research and Development Program of China (2022YFC2703500, 2021YFC2700601)/ GR - Key Research and Development Program of Zhejiang Province (2021C03098)/ GR - National Natural Science Foundation of China (U23A20404, 82394424)/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250123 PL - England TA - BJOG JT - BJOG : an international journal of obstetrics and gynaecology JID - 100935741 SB - IM MH - Humans MH - Female MH - *Embryo Transfer/methods MH - Child, Preschool MH - *Child Development MH - Male MH - Child MH - Adult MH - Cryopreservation MH - Pregnancy MH - *Cognition MH - Cohort Studies MH - Intelligence PMC - PMC11997633 OTO - NOTNLM OT - cognitive function OT - laser-assisted hatching OT - offspring health COIS- The authors declare no conflicts of interest. EDAT- 2025/01/23 12:36 MHDA- 2025/04/15 06:23 PMCR- 2025/04/15 CRDT- 2025/01/23 06:13 PHST- 2024/10/25 00:00 [received] PHST- 2024/12/04 00:00 [accepted] PHST- 2025/04/15 06:23 [medline] PHST- 2025/01/23 12:36 [pubmed] PHST- 2025/01/23 06:13 [entrez] PHST- 2025/04/15 00:00 [pmc-release] AID - BJO18047 [pii] AID - 10.1111/1471-0528.18047 [doi] PST - ppublish SO - BJOG. 2025 Apr;132(Suppl 2):18-25. doi: 10.1111/1471-0528.18047. Epub 2025 Jan 23. PMID- 39845554 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250721 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 15 DP - 2024 TI - Association between the Taq1A polymorphism and problematic media use in preadolescent children. PG - 1395957 LID - 10.3389/fpsyg.2024.1395957 [doi] LID - 1395957 AB - OBJECTIVE: Problematic media use (PMU) is addiction-like media use. No study has examined if genetic factors for addiction relate to PMU during childhood. This study tested the association between genetic risk factors for addiction and PMU among 9-to-12-year-olds. METHOD: Data were from a cohort of 9-to-12-year-olds recruited from Northern New England, 2018-2022, for a study examining obesity risk among children. Two polymorphisms related to dopaminergic (ANNK1 rs1800497 [the Taq1A polymorphism] and COMT rs4680) and one related to nicotinic (CHRNA4 rs1044396) pathways that were previously associated with internet addiction or internet video game addiction in adolescents and young adults were genotyped. Parent-reported PMU for children was measured with a validated nine-item scale (range for final scores: 1 to 5); higher scores indicate more severe PMU. RESULTS: Among children (n = 180; 43.9% female; 90.0% white, non-Hispanic; 82.2% of parents were college graduates), the median PMU score was 2.22 (IQR: 1.78, 2.78). In a linear regression model adjusted for child age, sex, European ancestry, and parent education, there was an additive association between the number of Taq1A1 alleles and PMU among children. Specifically, geometric mean PMU scores were 8.6% greater for each additional copy of the Taq1A1 allele (p = 0.030; R (2) = 5.2%). No other polymorphisms were statistically associated with PMU at the p < 0.05 level. CONCLUSION: These preliminary findings suggest that a genetic predisposition to reduced dopamine sensitivity as indicated by the Taq1A polymorphism may relate to PMU in early adolescence. Findings need confirmation in larger samples. CI - Copyright (c) 2025 Emond, Renier, Yeum, Carlson, Ballarino and Gilbert-Diamond. FAU - Emond, Jennifer A AU - Emond JA AD - Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth College, Lebanon, NH, United States. AD - Department of Pediatrics, Geisel School of Medicine at Dartmouth College, Lebanon, NH, United States. FAU - Renier, Timothy J AU - Renier TJ AD - Department of Epidemiology, Geisel School of Medicine at Dartmouth College, Lebanon, NH, United States. FAU - Yeum, Dabin AU - Yeum D AD - Department of Epidemiology, Geisel School of Medicine at Dartmouth College, Lebanon, NH, United States. FAU - Carlson, Delaina D AU - Carlson DD AD - Department of Epidemiology, Geisel School of Medicine at Dartmouth College, Lebanon, NH, United States. FAU - Ballarino, Grace A AU - Ballarino GA AD - Department of Epidemiology, Geisel School of Medicine at Dartmouth College, Lebanon, NH, United States. FAU - Gilbert-Diamond, Diane AU - Gilbert-Diamond D AD - Department of Pediatrics, Geisel School of Medicine at Dartmouth College, Lebanon, NH, United States. AD - Department of Epidemiology, Geisel School of Medicine at Dartmouth College, Lebanon, NH, United States. AD - Department of Medicine, Geisel School of Medicine at Dartmouth College, Lebanon, NH, United States. LA - eng GR - K01 DK117971/DK/NIDDK NIH HHS/United States GR - P30 CA023108/CA/NCI NIH HHS/United States GR - R01 HD092604/HD/NICHD NIH HHS/United States GR - T32 CA260262/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20250108 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC11752389 OTO - NOTNLM OT - Taq1A OT - addiction OT - children OT - problematic media use OT - screen time COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/01/23 06:26 MHDA- 2025/01/23 06:27 PMCR- 2025/01/08 CRDT- 2025/01/23 04:46 PHST- 2024/07/30 00:00 [received] PHST- 2024/12/24 00:00 [accepted] PHST- 2025/01/23 06:27 [medline] PHST- 2025/01/23 06:26 [pubmed] PHST- 2025/01/23 04:46 [entrez] PHST- 2025/01/08 00:00 [pmc-release] AID - 10.3389/fpsyg.2024.1395957 [doi] PST - epublish SO - Front Psychol. 2025 Jan 8;15:1395957. doi: 10.3389/fpsyg.2024.1395957. eCollection 2024. PMID- 39843619 OWN - NLM STAT- MEDLINE DCOM- 20250521 LR - 20260621 IS - 1476-5497 (Electronic) IS - 0307-0565 (Print) IS - 0307-0565 (Linking) VI - 49 IP - 5 DP - 2025 May TI - Are associations of adulthood overweight and obesity with all-cause mortality, cardiovascular disease, and obesity-related cancer modified by comparative body weight at age 10 years in the UK Biobank study? PG - 902-914 LID - 10.1038/s41366-025-01718-4 [doi] AB - OBJECTIVE: Adults living with overweight or obesity do not represent a single homogenous group in terms of mortality and disease risks. The aim of our study was to evaluate how the associations of adulthood overweight and obesity with mortality and incident disease are modified by (i.e., differ according to) self-reported childhood body weight categories. METHODS: The sample comprised 191,181 men and 242,806 women aged 40-69 years (in 2006-2010) in the UK Biobank. The outcomes were all-cause mortality, incident cardiovascular disease (CVD), and incident obesity-related cancer. Cox proportional hazards regression models were used to estimate how the associations with the outcomes of adulthood weight status (normal weight, overweight, obesity) differed according to perceived body weight at age 10 years (about average, thinner, plumper). To triangulate results using an approach that better accounts for confounding, analyses were repeated using previously developed and validated polygenic risk scores (PRSs) for childhood body weight and adulthood BMI, categorised into three-tier variables using the same proportions as in the observational variables. RESULTS: In both sexes, adulthood obesity was associated with higher hazards of all outcomes. However, the associations of obesity with all-cause mortality and incident CVD were stronger in adults who reported being thinner at 10 years. For example, obesity was associated with a 1.28 (1.21, 1.35) times higher hazard of all-cause mortality in men who reported being an average weight child, but among men who reported being a thinner child this estimate was 1.63 (1.53, 1.75). The ratio between these two estimates was 1.28 (1.17, 1.40). There was also some evidence that the associations of obesity with all-cause mortality and incident CVD were stronger in adults who reported being plumper at 10 years. In genetic analyses, however, there was no evidence that the association of obesity (according to the adult PRS) with mortality or incident CVD differed according to childhood body size (according to the child PRS). For incident obesity-related cancer, the evidence for effect modification was limited and inconsistent between the observational and genetic analyses. CONCLUSIONS: Greater risks for all-cause mortality and incident CVD in adults with obesity who perceive themselves to have been a thinner or plumper than average child may be due to confounding and/or recall bias. CI - (c) 2025. The Author(s). FAU - Johnson, William AU - Johnson W AUID- ORCID: 0000-0002-0347-4354 AD - School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK. W.O.Johnson@lboro.ac.uk. AD - National Institute for Health and Care Research (NIHR) Leicester Biomedical Research Centre, University Hospitals of Leicester National Health Service (NHS) Trust and the University of Leicester, Leicester, UK. W.O.Johnson@lboro.ac.uk. FAU - Norris, Tom AU - Norris T AD - Institute of Sport Exercise and Health, Division of Surgery and Interventional Science, University College London, London, UK. FAU - Pearson, Natalie AU - Pearson N AD - School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK. FAU - Petherick, Emily S AU - Petherick ES AUID- ORCID: 0000-0001-6778-8128 AD - School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK. FAU - King, James A AU - King JA AUID- ORCID: 0000-0002-8174-9173 AD - School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK. AD - National Institute for Health and Care Research (NIHR) Leicester Biomedical Research Centre, University Hospitals of Leicester National Health Service (NHS) Trust and the University of Leicester, Leicester, UK. FAU - Willis, Scott A AU - Willis SA AUID- ORCID: 0000-0001-8624-1427 AD - School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK. AD - National Institute for Health and Care Research (NIHR) Leicester Biomedical Research Centre, University Hospitals of Leicester National Health Service (NHS) Trust and the University of Leicester, Leicester, UK. FAU - Hardy, Rebecca AU - Hardy R AD - School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK. FAU - Paudel, Susan AU - Paudel S AD - Institute for Physical Activity and Nutrition (IPAN), Deakin University, Burwood, VIC, Australia. FAU - Haycraft, Emma AU - Haycraft E AUID- ORCID: 0000-0002-7359-1759 AD - School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK. FAU - Baker, Jennifer L AU - Baker JL AUID- ORCID: 0000-0002-9649-6615 AD - Center for Clinical Research and Prevention, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark. FAU - Hamer, Mark AU - Hamer M AUID- ORCID: 0000-0002-8726-7992 AD - Institute of Sport Exercise and Health, Division of Surgery and Interventional Science, University College London, London, UK. AD - National Institute for Health and Care Research (NIHR) University College London Hospitals Biomedical Research Centre, London, UK. FAU - Stensel, David J AU - Stensel DJ AUID- ORCID: 0000-0001-9119-8590 AD - School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK. AD - National Institute for Health and Care Research (NIHR) Leicester Biomedical Research Centre, University Hospitals of Leicester National Health Service (NHS) Trust and the University of Leicester, Leicester, UK. AD - Faculty of Sport Sciences, Waseda University, Tokorozawa, Japan. AD - Department of Sports Science and Physical Education, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong, China. FAU - Tilling, Kate AU - Tilling K AD - MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. FAU - Richardson, Tom G AU - Richardson TG AD - MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. LA - eng GR - MR/P023347/1/UK Medical Research Council/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250123 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 SB - IM MH - Humans MH - Male MH - Female MH - United Kingdom/epidemiology MH - Middle Aged MH - *Cardiovascular Diseases/epidemiology/mortality/etiology MH - *Neoplasms/epidemiology/mortality/etiology MH - Adult MH - Aged MH - *Obesity/complications/epidemiology/mortality MH - *Overweight/epidemiology/complications/mortality MH - *Body Weight/physiology MH - Child MH - Body Mass Index MH - Biological Specimen Banks MH - Risk Factors MH - Cause of Death MH - UK Biobank PMC - PMC12095051 COIS- Competing interests: All authors declare that they have no conflict of interest. TGR is a full-time employee of GlaxoSmithKline outside of this research. TN is a full-time employee of AstraZeneca outside of this research. JLB declares receiving consulting fees from Novo Nordisk A/S. EDAT- 2025/01/23 05:15 MHDA- 2025/05/22 00:28 PMCR- 2025/01/23 CRDT- 2025/01/22 23:22 PHST- 2024/08/27 00:00 [received] PHST- 2025/01/14 00:00 [accepted] PHST- 2024/12/17 00:00 [revised] PHST- 2025/05/22 00:28 [medline] PHST- 2025/01/23 05:15 [pubmed] PHST- 2025/01/22 23:22 [entrez] PHST- 2025/01/23 00:00 [pmc-release] AID - 10.1038/s41366-025-01718-4 [pii] AID - 1718 [pii] AID - 10.1038/s41366-025-01718-4 [doi] PST - ppublish SO - Int J Obes (Lond). 2025 May;49(5):902-914. doi: 10.1038/s41366-025-01718-4. Epub 2025 Jan 23. PMID- 39841984 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250212 IS - 2561-6722 (Electronic) IS - 2561-6722 (Linking) VI - 8 DP - 2025 Jan 22 TI - Assessing and Enhancing Nutrition and Physical Activity Environments in Early Childhood Education and Care Centers: Scoping Review of eHealth Tools. PG - e68372 LID - 10.2196/68372 [doi] LID - e68372 AB - BACKGROUND: Early childhood is a critical period for shaping lifelong health behaviors, making early childhood education and care (ECEC) environments ideal for implementing nutrition and physical activity interventions. eHealth tools are increasingly utilized in ECEC settings due to their accessibility, scalability, and cost-effectiveness, demonstrating promise in enhancing educators' practices. Despite the potential effectiveness of these eHealth approaches, a comprehensive collection of available evidence on eHealth tools designed to assess or support best practices for nutrition or physical activity in ECECs is currently lacking. OBJECTIVE: The primary objective of this scoping review is to map the range of available eHealth tools designed to assess or deliver interventions aimed at improving nutrition or physical activity in ECEC settings, while evaluating their components, theoretical foundations, and effectiveness. METHODS: This scoping review adhered to the Joanna Briggs Institute methodology, in accordance with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) checklist. The objectives, inclusion criteria, and methods for this review were predefined and specified. Eligibility criteria were (1) early childhood educators (population); (2) eHealth (digital) technologies, such as websites, smartphone apps, emails, and social media; and (3) tools designed to assess or deliver interventions aimed at improving best practices for nutrition, physical activity, or both within ECEC settings (context). A search was conducted across 5 electronic databases (PubMed, Scopus, CINAHL Plus, ERIC, and Embase) to identify white literature, and 3 electronic databases (ProQuest, Google Scholar, and targeted Google search), along with hand-searching of reference lists, were used to identify gray literature. All literature was reported in English or French, with the search extending until May 2024. Separate data charting tools were used for white and gray literature. RESULTS: The search strategy identified 3064 results for white literature, yielding 2653 unique citations after duplicates were removed. Full texts for 65 citations were retrieved and screened for inclusion, resulting in 30 studies eligible for data extraction and analysis. The most common study design was a randomized controlled trial, comprising 16 studies (53%). The largest proportion of studies were conducted in the United States (11 studies, 37%). In total, 19 eHealth tools were identified, targeting nutrition (8 tools, 42%), physical activity (5 tools, 26%), or both nutrition and physical activity (6 tools, 32%). All tools were web based (19 tools, 100%). The gray literature search yielded 1054 results, of which 17 were moved to full-text screening, and 7 met the eligibility criteria for data extraction and analysis. The tools identified in the gray literature originated in Canada (4 tools, 57%) and the United States (3 tools, 43%). The majority targeted nutrition (4 tools, 57%) and were primarily web based (6 tools, 86%), with 1 mobile app (1 tool, 14%). CONCLUSIONS: This scoping review mapped the available eHealth tools designed to improve nutrition or physical activity environments in ECEC settings, highlighting the growing emphasis on web-based tools and the need for psychometric testing. Future research should systematically evaluate the effectiveness of these tools, particularly those addressing both nutrition and physical activity, to identify the key factors that contribute to long-term behavior change. TRIAL REGISTRATION: Open Science Framework XTRNZ; https://osf.io/xtrnz. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR2-10.2196/52252. CI - (c)Joyce Hayek, Kelsi Dickson, Lynne M Z Lafave. Originally published in JMIR Pediatrics and Parenting (https://pediatrics.jmir.org), 22.01.2025. FAU - Hayek, Joyce AU - Hayek J AUID- ORCID: 0000-0003-1985-1756 AD - Department of Health and Physical Education, Mount Royal University, Calgary, AB, Canada. FAU - Dickson, Kelsi AU - Dickson K AUID- ORCID: 0009-0001-1568-5511 AD - Department of Health and Physical Education, Mount Royal University, Calgary, AB, Canada. FAU - Lafave, Lynne M Z AU - Lafave LMZ AUID- ORCID: 0000-0002-9781-3213 AD - Department of Health and Physical Education, Mount Royal University, Calgary, AB, Canada. LA - eng PT - Journal Article PT - Review DEP - 20250122 PL - Canada TA - JMIR Pediatr Parent JT - JMIR pediatrics and parenting JID - 101727244 PMC - PMC11809617 OTO - NOTNLM OT - ECE OT - ECEC OT - diet OT - digital public health OT - digital technology OT - eHealth OT - early childhood education and care OT - early childhood educators OT - eating OT - health technology OT - knowledge synthesis COIS- Conflicts of Interest: None declared. EDAT- 2025/01/22 18:25 MHDA- 2025/01/22 18:26 PMCR- 2025/01/22 CRDT- 2025/01/22 16:53 PHST- 2024/11/05 00:00 [received] PHST- 2024/12/23 00:00 [accepted] PHST- 2024/12/16 00:00 [revised] PHST- 2025/01/22 18:26 [medline] PHST- 2025/01/22 18:25 [pubmed] PHST- 2025/01/22 16:53 [entrez] PHST- 2025/01/22 00:00 [pmc-release] AID - v8i1e68372 [pii] AID - 10.2196/68372 [doi] PST - epublish SO - JMIR Pediatr Parent. 2025 Jan 22;8:e68372. doi: 10.2196/68372. PMID- 39841362 OWN - NLM STAT- MEDLINE DCOM- 20260307 LR - 20260920 IS - 2196-8837 (Electronic) IS - 2197-3792 (Print) IS - 2196-8837 (Linking) VI - 13 IP - 2 DP - 2026 Apr TI - Social Networks, Health Support, and Dietary Intake in Mothers Receiving Home Visiting Services. PG - 737-748 LID - 10.1007/s40615-025-02286-z [doi] AB - Home visiting programs (HVPs) provide services to pregnant individuals and parents of young children to improve families' health and well-being. However, little is known about these families' social contexts. This study explores the social networks and dietary intake of mothers enrolled in a HVP, focusing on health support and health undermining. Cross-sectional data from 76 mothers enrolled in a HVP in Los Angeles County were collected by interview, using validated measures. Almost all mothers (95.7%) had one or more health supporters, while 55.1% had one or more health underminers. Some key findings related to health support were that mothers with higher income had more health supporters in their network (b = 1.36, p = 0.03), and network members were more likely to be health supporters if they were a romantic partner (OR = 3.41, p < 0.001), a resource-based connection (OR = 3.46, p < 0.01), or if they lived in the same neighborhood as the mother (OR = 1.68, p < 0.05). Further, having a health supporter who lived in the same neighborhood was associated with consuming more (1 + daily servings) vegetables (OR = 3.0, p < 0.05) and no sugar-sweetened beverages (OR = 0.29, p < 0.05). There were fewer findings related to health undermining: network members more likely to be underminers were romantic partners (OR = 8.93, p < .0001), and those perceived as having overweight or obesity (OR = 3.98, p < 0.001), but health undermining did not predict dietary intake. Overall, a broad set of network features were linked with health support, and given that some types of support were linked with better diet, network-based diet interventions leveraging health support may be effective in this priority population. CI - (c) 2025. The Author(s). FAU - Miller, Sydney AU - Miller S AD - Keck School of Medicine, University of Southern California, Los Angeles, USA. sm4866@drexel.edu. AD - Dornsife School of Public Health, Drexel University, Philadelphia, PA, 19104, USA. sm4866@drexel.edu. FAU - Salvy, Sarah-Jeanne AU - Salvy SJ AD - Research Center for Health Equity, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, USA. FAU - Caceres, Nenette AU - Caceres N AD - Research Center for Health Equity, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, USA. FAU - Pickering, Trevor AU - Pickering T AD - Keck School of Medicine, University of Southern California, Los Angeles, USA. FAU - Bruine de Bruin, Wandi AU - Bruine de Bruin W AD - Center for Economic and Social Research, Arts and Sciences, Dornsife College of Letters, University of Southern California, Los Angeles, USA. AD - Sol Price School of Public Policy and Dornsife Department of Psychology, University of Southern California, Los Angeles, USA. AD - Schaeffer Center for Health Policy and Economics, University for Southern California, Los Angeles, USA. FAU - Valente, Tom W AU - Valente TW AD - Keck School of Medicine, University of Southern California, Los Angeles, USA. FAU - Wilson, John P AU - Wilson JP AD - Keck School of Medicine, University of Southern California, Los Angeles, USA. AD - Spatial Sciences Institute, Arts and Sciences, Dornsife College of Letters, University of Southern California, Los Angeles, USA. AD - Viterbi School of Engineering and the School of Architecture, University of Southern California, Los Angeles, USA. FAU - de la Haye, Kayla AU - de la Haye K AD - Center for Economic and Social Research, Arts and Sciences, Dornsife College of Letters, University of Southern California, Los Angeles, USA. AD - Spatial Sciences Institute, Arts and Sciences, Dornsife College of Letters, University of Southern California, Los Angeles, USA. AD - Department of Psychology, Arts and Sciences, Dornsife College of Letters, University of Southern California, Los Angeles, USA. LA - eng GR - R01 HD092483/HD/NICHD NIH HHS/United States GR - R01HD096293/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ GR - R01HD092483-01/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ GR - R01 HD096293/HD/NICHD NIH HHS/United States GR - R01 DK130851/DK/NIDDK NIH HHS/United States GR - F31 HL160131/HL/NHLBI NIH HHS/United States GR - S&CC-IRG Award 2125616/National Science Foundation/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250122 PL - Switzerland TA - J Racial Ethn Health Disparities JT - Journal of racial and ethnic health disparities JID - 101628476 SB - IM MH - Humans MH - Female MH - Adult MH - Cross-Sectional Studies MH - *Social Support MH - *Mothers/statistics & numerical data/psychology MH - *House Calls/statistics & numerical data MH - *Diet/statistics & numerical data MH - Los Angeles MH - Young Adult MH - Pregnancy PMC - PMC12863036 MID - NIHMS2127515 OTO - NOTNLM OT - Diet disparities OT - Health support OT - Health undermining OT - Maternal health OT - Social networks COIS- Declarations. Ethics Approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of the University of Southern California (HS-18-00025). Consent to Participate: Written informed consent was obtained from all individual participants included in the study. Competing Interests: The authors declare no competing interests. EDAT- 2025/01/22 12:30 MHDA- 2026/03/07 18:38 PMCR- 2025/01/22 CRDT- 2025/01/22 11:23 PHST- 2024/05/07 00:00 [received] PHST- 2025/01/02 00:00 [accepted] PHST- 2024/12/31 00:00 [revised] PHST- 2026/03/07 18:38 [medline] PHST- 2025/01/22 12:30 [pubmed] PHST- 2025/01/22 11:23 [entrez] PHST- 2025/01/22 00:00 [pmc-release] AID - 10.1007/s40615-025-02286-z [pii] AID - 2286 [pii] AID - 10.1007/s40615-025-02286-z [doi] PST - ppublish SO - J Racial Ethn Health Disparities. 2026 Apr;13(2):737-748. doi: 10.1007/s40615-025-02286-z. Epub 2025 Jan 22. PMID- 39839402 OWN - NLM STAT- MEDLINE DCOM- 20250502 LR - 20250523 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 12 DP - 2024 TI - Health literacy assessment and analysis of influencing factors in pregnant women with gestational diabetes mellitus in Southwest China. PG - 1477706 LID - 10.3389/fpubh.2024.1477706 [doi] LID - 1477706 AB - OBJECTIVE: The main objectives of our study are evaluating the health literacy level among women with gestational diabetes mellitus (GDM) in Southwest China and explore the influencing factors, using a multidimensional health literacy assessment scale (Chinese version of the HLS-14). Given that the HLS-14 has not been used in GDM previously, its reliability and validity testing was included as a secondary objective. METHOD: It was a cross-sectional survey with 565 GDM pregnancies. The Maternal and child health information access questionnaire, Chinese version of the HLS-14, Perceived Social Support Scale (PSSS) and General Self-efficacy Scale (GSES) was used to collect health information access behaviors, health literacy, social support and self-efficacy levels, respectively. SPSS 21.0 was used for descriptive statistical, multiple stepwise linear regression analysis and exploratory factor analysis (EFA). Amos 26.0 was used for confirmatory factor analysis (CFA). RESULTS: The Chinese version of HLS-14 has good reliability and validity in GDM pregnancies. The Cronbach's alpha are 0.849, 0.866, 0.859, and 0.883, respectively. The exploratory factor analysis extracted three common factors with a cumulative variance contribution rate of 68.405%. The confirmatory factor analysis model fit was good (chi(2)/df = 2.595, RMSEA = 0.055, IFI = 0.970, TLI = 0.963, CFI = 0.970). The HL level in pregnancies with GDM was moderate with a mean score of 3.26 +/- 0.41, of which 24.10% had limited HL, 41.87% had moderate HL, and 34.03% had adequate HL. Regression analysis showed that the women with higher family support (beta = 0.298, p < 0.001), recording pregnancy management diary (beta = 0.199, p < 0.001), higher the family income (beta = 0.140, p < 0.001), lower pre-pregnancy BMI (beta = -0.116, p = 0.004), longer time spent searching for health information (beta = 0.111, p = 0.006), and searching for health information through a medical health information website (beta = 0.093, p = 0.019) had higher HL levels. These variables explained 23.1% of the variance in HL. CONCLUSION: The Chinese version of the HLS-14 has good applicability in the GDM pregnancies. The HL level of them is moderate, needs to be improved. Healthcare professionals should focus on the GDM population with low family income and high pre-pregnancy BMI, fully mobilize their social support system, provide reliable access to information, encourage all GDM pregnancies to use pregnancy management diaries to record their self-management behaviors, and ensure the effectiveness of health education. CI - Copyright (c) 2025 Tang, Gu, Guo, Fu, He, Song and Li. FAU - Tang, Fangmei AU - Tang F AD - Department of Obstetric Nursing, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. FAU - Gu, Li AU - Gu L AD - Department of Obstetric Nursing, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. FAU - Guo, Xiujing AU - Guo X AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. AD - Department of Gynecological Nursing, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Fu, Wenjing AU - Fu W AD - Department of Obstetric Nursing, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. FAU - He, Benyi AU - He B AD - Department of Hepatobiliary Pancreatic Vascular Surgery, The First Hospital of Kunming, Kunming, China. FAU - Song, Yuqing AU - Song Y AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. AD - Department of Gynecological Nursing, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Li, Dehua AU - Li D AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. AD - Office of Operations Management and Evaluation, West China Second University Hospital, Sichuan University, Chengdu, China. LA - eng PT - Journal Article DEP - 20250107 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Female MH - *Diabetes, Gestational/psychology MH - Pregnancy MH - China MH - *Health Literacy/statistics & numerical data MH - Cross-Sectional Studies MH - Adult MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Social Support MH - *Pregnant People/psychology MH - Self Efficacy MH - Factor Analysis, Statistical PMC - PMC11747004 OTO - NOTNLM OT - GDM OT - HLS-14 OT - gestational diabetes mellitus OT - health literacy OT - self-efficacy OT - social support COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/01/22 06:26 MHDA- 2025/01/22 06:27 PMCR- 2025/01/07 CRDT- 2025/01/22 04:49 PHST- 2024/08/08 00:00 [received] PHST- 2024/12/16 00:00 [accepted] PHST- 2025/01/22 06:27 [medline] PHST- 2025/01/22 06:26 [pubmed] PHST- 2025/01/22 04:49 [entrez] PHST- 2025/01/07 00:00 [pmc-release] AID - 10.3389/fpubh.2024.1477706 [doi] PST - epublish SO - Front Public Health. 2025 Jan 7;12:1477706. doi: 10.3389/fpubh.2024.1477706. eCollection 2024. PMID- 39838540 OWN - NLM STAT- MEDLINE DCOM- 20250502 LR - 20250523 IS - 2574-173X (Electronic) IS - 2574-173X (Linking) VI - 45 IP - 1 DP - 2025 Mar TI - The Association Between Autism Spectrum Disorders and Dietary Intake of Carbohydrates in School-Aged Children in Iran: A Case-Control Study. PG - e12521 LID - 10.1002/npr2.12521 [doi] LID - e12521 AB - BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with both genetic and environmental risk factors. Imbalanced dietary Intake has recently been proposed as a possible environmental risk factor for ASD. The purpose of this study was to investigate the possible connection between ASD and intake of various carbohydrate types. METHODS: 110 patients with autism from 5 to 15 years of age have been included as the case group and 110 neurotypical children who are part of a similar age category have been chosen as controls for this case-control study. To estimate the dietary intake of carbohydrates, a validated food frequency questionnaire (FFQ) was used. RESULTS: Positive connections were found between ASD and the intake of sugar (OR = 1.03, CI 95%: 1.02-1.06, p = 0.001), and maltose (OR = 2.09, CI 95%: 1.37-3.20, p = 0.001). A reverse correlation was found between ASD and dietary intake of carbohydrates (OR = 0.97, CI 95%: 0.96-0.98, p = 0.001), fructose (OR = 0.85, CI 95%: 0.77-0.94, p = 0.002), and lactose (OR = 0.89, CI 95%: 0.83-0.96, p = 0.002). CONCLUSION: This study showed a direct link between autism and the intake of sugar and maltose and an inverse connection between autism and the dietary intake of total carbohydrate, fructose, and lactose. There is a need to carry out additional long-term studies. CI - (c) 2025 The Author(s). Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology. FAU - Tajadod, Shirin AU - Tajadod S AD - Department of Nutrition, School of Public Health, International Campus, Iran University of Medical Sciences, Tehran, Iran. FAU - Roumi, Zahra AU - Roumi Z AD - Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran. FAU - Abbas Torki, Saheb AU - Abbas Torki S AD - Department of Nutrition, Faculty of Nutrition Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Mousavi Shalmani, Seyedeh Hayedeh AU - Mousavi Shalmani SH AD - Guilan University of Medical Sciences, Rasht, Iran. FAU - Moradi, Mahdi AU - Moradi M AD - Department of Clinical Psychology, Payame Noor University (PNU), Tehran, Iran. FAU - Saeedirad, Zahra AU - Saeedirad Z AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Abbasi Mobarakeh, Khadijeh AU - Abbasi Mobarakeh K AD - Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Mohammadi, Saeideh AU - Mohammadi S AD - Zanjan University of Medical Sciences, Zanjan, Iran. FAU - Shekari, Soheila AU - Shekari S AD - Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran. FAU - Mirzaee, Pouya AU - Mirzaee P AD - Department of Medicine, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran. FAU - Bahmani, Parsa AU - Bahmani P AD - Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Houshyar-Rad, Anahita AU - Houshyar-Rad A AD - Department of Nutrition Research, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Doaei, Saeid AU - Doaei S AUID- ORCID: 0000-0002-1337-4963 AD - Department of Community Nutrition, School of Nutrition and Food Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. LA - eng GR - 16436/Shahid Beheshti University of Medical Sciences/ PT - Journal Article PL - United States TA - Neuropsychopharmacol Rep JT - Neuropsychopharmacology reports JID - 101719700 RN - 0 (Dietary Carbohydrates) SB - IM MH - Humans MH - *Autism Spectrum Disorder/epidemiology MH - Child MH - Case-Control Studies MH - Iran/epidemiology MH - Male MH - Female MH - Adolescent MH - *Dietary Carbohydrates/adverse effects/administration & dosage MH - Child, Preschool PMC - PMC11750687 OTO - NOTNLM OT - autism Spectrum disorder OT - carbohydrates OT - dietary intake COIS- The authors declare no conflicts of interest. EDAT- 2025/01/22 06:26 MHDA- 2025/01/22 06:27 PMCR- 2025/01/21 CRDT- 2025/01/22 00:43 PHST- 2024/12/13 00:00 [revised] PHST- 2024/08/20 00:00 [received] PHST- 2024/12/17 00:00 [accepted] PHST- 2025/01/22 06:27 [medline] PHST- 2025/01/22 06:26 [pubmed] PHST- 2025/01/22 00:43 [entrez] PHST- 2025/01/21 00:00 [pmc-release] AID - NPR212521 [pii] AID - 10.1002/npr2.12521 [doi] PST - ppublish SO - Neuropsychopharmacol Rep. 2025 Mar;45(1):e12521. doi: 10.1002/npr2.12521. PMID- 39838085 OWN - NLM STAT- MEDLINE DCOM- 20250513 LR - 20250515 IS - 1476-5640 (Electronic) IS - 0954-3007 (Print) IS - 0954-3007 (Linking) VI - 79 IP - 5 DP - 2025 May TI - Differences between the normal and perceived appropriate portion sizes of discretionary foods. PG - 419-426 LID - 10.1038/s41430-025-01569-2 [doi] AB - BACKGROUND: There are limited data on the amount of discretionary foods that people normally consume and consider as appropriate at one eating occasion. This study aimed to provide an overview of the range and assess differences of the 'normal portion size' and 'perceived appropriate portion size' of energy-dense nutrient-poor discretionary foods among consumers aged 18-65 years. METHODS: To measure normal and perceived appropriate portion sizes, a validated online image-series questionnaire consisting of eight successive portion size options for 15 discretionary foods was completed at two timepoints. Quantile regression models were used to estimate the ranges (lower boundary at 17(th) percentile, upper boundary at 83(rd) percentile) of normal and perceived appropriate portion sizes selected by two thirds of the study population. Models were adjusted for the effects of potential influencing factors including biological sex, age, usual physical activity level, cooking confidence, socio-economic status, body mass index, and baseline hunger levels. RESULTS: A final sample of 295 participants were included in the analysis (51% females, mean age 39.5 +/- 14.1 years). The normal portion sizes were significantly higher than the perceived appropriate portion sizes across all test foods, with the effects of sex, age, and BMI being significant for some foods. CONCLUSION: The finding suggests that consumers would normally consume a portion size that was larger than what they perceive to be appropriate for discretionary foods. The estimated lower and upper boundaries would be valuable for the development of pragmatic public health messages to empower consumers towards better portion control. CI - (c) 2025. The Author(s). FAU - Liu, Qingzhou AU - Liu Q AUID- ORCID: 0000-0002-5778-9159 AD - School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, 2006, Australia. AD - Charles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia. FAU - Allman-Farinelli, Margaret AU - Allman-Farinelli M AUID- ORCID: 0000-0002-6478-1374 AD - Charles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia. AD - Discipline of Nutrition and Dietetics, Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia. FAU - Rangan, Anna AU - Rangan A AUID- ORCID: 0000-0003-1815-844X AD - Charles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia. anna.rangan@sydney.edu.au. AD - Discipline of Nutrition and Dietetics, Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia. anna.rangan@sydney.edu.au. LA - eng PT - Journal Article DEP - 20250121 PL - England TA - Eur J Clin Nutr JT - European journal of clinical nutrition JID - 8804070 SB - IM MH - Humans MH - Adult MH - *Portion Size/psychology MH - Female MH - Male MH - Middle Aged MH - Young Adult MH - Aged MH - Adolescent MH - Surveys and Questionnaires MH - Body Mass Index MH - *Feeding Behavior/psychology MH - Energy Intake PMC - PMC12069090 COIS- Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki. The study approved by the Human Ethics Committee of the University of Sydney (ethics approval number 2022/147). Informed consent was obtained from all participants. EDAT- 2025/01/22 05:32 MHDA- 2025/05/13 13:49 PMCR- 2025/01/21 CRDT- 2025/01/21 23:27 PHST- 2024/03/06 00:00 [received] PHST- 2025/01/16 00:00 [accepted] PHST- 2024/12/19 00:00 [revised] PHST- 2025/05/13 13:49 [medline] PHST- 2025/01/22 05:32 [pubmed] PHST- 2025/01/21 23:27 [entrez] PHST- 2025/01/21 00:00 [pmc-release] AID - 10.1038/s41430-025-01569-2 [pii] AID - 1569 [pii] AID - 10.1038/s41430-025-01569-2 [doi] PST - ppublish SO - Eur J Clin Nutr. 2025 May;79(5):419-426. doi: 10.1038/s41430-025-01569-2. Epub 2025 Jan 21. PMID- 39835543 OWN - NLM STAT- MEDLINE DCOM- 20250731 LR - 20250731 IS - 1473-5865 (Electronic) IS - 1060-152X (Linking) VI - 34 IP - 5 DP - 2025 Sep 1 TI - Interobserver reliability of Pirani scoring for idiopathic clubfoot in walking-age children. PG - 484-487 LID - 10.1097/BPB.0000000000001236 [doi] AB - Pirani scoring system is one of the most commonly used tools to assess the initial deformity, monitor the treatment progression, and identify relapse in clubfoot. The method has been demonstrated to correlate well with the sequential correction of deformity for children under age 1 year. We conducted a study to examine the interobserver reliability of Pirani scores in children of walking-age. The retrospective study focused on children >1 year age with idiopathic clubfoot presenting for primary treatment. The Pirani scores at presentation charted by pediatric orthopedic consultant and orthopedic registrars were compared and the intergroup reliability calculated using Cohen's kappa. Thirty-five feet in 22 clubfoot children (13 bilateral) were analyzed. The mean child's age was 3.9 years. The mean Pirani score for the consultant was 3.2 and for the registrars was 3.6. The overall reliability of Pirani score was 0.3 ('fair'). The highest reliability was calculated for the head of talus (0.55), rigid equinus (0.48), and lateral border (0.44) (moderate). A lower kappa was recorded for medial crease (0.28), posterior crease (0.34), and empty heel (0.4). The registrars graded the clubfoot deformity in the walking-age child as more severe compared to the consultant. The mean Pirani scores for medial and posterior crease subcomponents were low. Contrary to the common perception, empty heel manifested even in this age group. Looking to the statistics of 'fair' reliability of Pirani score for older child, further research is warranted to develop more reliable scores for assessment and treatment of clubfoot. CI - Copyright (c) 2025 Wolters Kluwer Health, Inc. All rights reserved. FAU - Agarwal, Anil AU - Agarwal A AD - Department of Paediatric Orthopaedics, Chacha Nehru Bal Chikitsalaya, Delhi, India. FAU - Upadhyay, Ashish AU - Upadhyay A FAU - Garg, Varun AU - Garg V FAU - Sachdeva, Kishmita AU - Sachdeva K FAU - Ks, Ankitha AU - Ks A FAU - Salot, Jainam AU - Salot J LA - eng PT - Journal Article DEP - 20250121 PL - United States TA - J Pediatr Orthop B JT - Journal of pediatric orthopedics. Part B JID - 9300904 SB - IM MH - Humans MH - *Clubfoot/diagnosis/physiopathology MH - Male MH - Female MH - Retrospective Studies MH - Reproducibility of Results MH - Child, Preschool MH - Observer Variation MH - *Walking/physiology MH - Child MH - Infant MH - *Severity of Illness Index OTO - NOTNLM OT - Pirani scores OT - clubfoot OT - walking-age child EDAT- 2025/01/21 12:26 MHDA- 2025/07/31 18:28 CRDT- 2025/01/21 06:53 PHST- 2025/07/31 18:28 [medline] PHST- 2025/01/21 12:26 [pubmed] PHST- 2025/01/21 06:53 [entrez] AID - 01202412-990000000-00236 [pii] AID - 10.1097/BPB.0000000000001236 [doi] PST - ppublish SO - J Pediatr Orthop B. 2025 Sep 1;34(5):484-487. doi: 10.1097/BPB.0000000000001236. Epub 2025 Jan 21. PMID- 39835265 OWN - NLM STAT- MEDLINE DCOM- 20250502 LR - 20260520 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 15 DP - 2024 TI - The role of vitamin D in slipped capital femoral epiphysis in children and adolescents: a retrospective case-control study. PG - 1497103 LID - 10.3389/fendo.2024.1497103 [doi] LID - 1497103 AB - OBJECTIVE: To explore the correlation between vitamin D levels, related endocrine/metabolic factors, and the risk of slipped capital femoral epiphysis (SCFE) in children and adolescents, and to assess whether vitamin D levels are associated with SCFE severity. METHODS: A retrospective case-control study was conducted from March 2014 to October 2023 in Shengjing hospital. Patients diagnosed with SCFE were categorized as the SCFE group. The control group consisted of healthy children matched by gender, age, weight, height, body mass index (BMI), and date of blood tests at a 1:2 ratio from the pediatric developmental clinic. The analysis included relevant laboratory tests such as 25-hydroxyvitamin D (25(OH)D), hemoglobin (Hb), serum alkaline phosphatase (ALP), calcium (Ca), phosphorus (P), and magnesium (Mg), etc. Univariate and multivariate conditional logistic regression analyses were conducted to identify factors associated with SCFE, with a particular focus on the correlation between 25(OH)D levels and the risk of SCFE. The study also explored whether these factors were correlated with SCFE severity, determined by measuring the slip angle and displacement on the anteroposterior pelvic or frog-leg lateral views. RESULTS: One hundred and twenty subjects were finally included, with 40 SCFE patients (36 males, 4 females) and 80 controls (72 males, 8 females). There were no significant differences in gender, age, weight, height, BMI, Hb, albumin (ALB), creatinine (Cr), free triiodothyronine (FT3), thyroid stimulating hormone (TSH), Ca, and P (P>0.05). Significant differences were found in 25(OH)D, ALP, free thyroxine (FT4), and Mg (P<0.05). The SCFE group had lower 25(OH)D and ALP levels but higher FT4 and Mg. Univariate analysis showed that 25(OH)D, FT4, and ALP were associated with SCFE, but multivariate analysis indicated only 25(OH)D had a significant correlation (P<0.05). 25(OH)D levels were not linked to SCFE severity (P>0.05). CONCLUSIONS: The results of this study indicate that a higher level of vitamin D is associated with a decreased risk of SCFE, suggesting potential benefits of vitamin D sufficiency. However, no correlation was observed between 25(OH)D levels and the severity of SCFE. Serum FT4 and ALP also seem to have some association with SCFE, but the clinical significance is unproven. Future multi-center studies in various regions are necessary to further validate the protective role of vitamin D against SCFE. CI - Copyright (c) 2025 Ning, Lin, Geng and Liu. FAU - Ning, Peng AU - Ning P AD - Department of Pediatric Orthopaedics, ShengJing Hospital of China Medical University, Shenyang, China. FAU - Lin, Shuting AU - Lin S AD - Department of Pediatric Orthopaedics, ShengJing Hospital of China Medical University, Shenyang, China. FAU - Geng, Huiyu AU - Geng H AD - Department of Pediatric Orthopaedics, ShengJing Hospital of China Medical University, Shenyang, China. FAU - Liu, Tianjing AU - Liu T AD - Department of Pediatric Orthopaedics, ShengJing Hospital of China Medical University, Shenyang, China. LA - eng PT - Journal Article DEP - 20250106 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) SB - IM MH - Humans MH - Male MH - Female MH - Retrospective Studies MH - Child MH - Adolescent MH - Case-Control Studies MH - *Vitamin D/blood/analogs & derivatives MH - *Slipped Capital Femoral Epiphyses/blood/epidemiology/etiology MH - Risk Factors PMC - PMC11743938 OTO - NOTNLM OT - 25 hydroxyvitamin D OT - adolescent OT - hormone OT - severity OT - slipped capital femoral epiphysis (SCFE) COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/01/21 09:02 MHDA- 2025/01/21 09:03 PMCR- 2024/01/01 CRDT- 2025/01/21 04:38 PHST- 2024/09/16 00:00 [received] PHST- 2024/12/10 00:00 [accepted] PHST- 2025/01/21 09:03 [medline] PHST- 2025/01/21 09:02 [pubmed] PHST- 2025/01/21 04:38 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2024.1497103 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2025 Jan 6;15:1497103. doi: 10.3389/fendo.2024.1497103. eCollection 2024. PMID- 39833426 OWN - NLM STAT- MEDLINE DCOM- 20250521 LR - 20260621 IS - 1476-5497 (Electronic) IS - 0307-0565 (Print) IS - 0307-0565 (Linking) VI - 49 IP - 5 DP - 2025 May TI - V̇O(2)peak estimation in people with overweight and obesity before and after a 14-week lifestyle intervention. PG - 864-871 LID - 10.1038/s41366-025-01713-9 [doi] AB - PURPOSE: This study aimed to investigate the validity and applicability of a non-exercise estimation of cardiorespiratory fitness using resting seismocardiography (SCG eV̇O(2)peak) in people with overweight and obesity before and after a 14-week lifestyle intervention. METHODS: The study was carried out at a Folk high school that offers 14-week courses on lifestyle changes where participants live at the school and voluntarily participate in daily lectures and activities. Sixty-seven men and women with age and body mass index between 18 and 70 years and 25-50 kg.m(-2) were tested at baseline, and 52 had a follow-up test after 14 weeks. Testing included the determination of anthropometric variables, an SCG eV̇O(2)peak at supine rest, and a gold standard V̇O(2)peak test on a cycle ergometer until voluntary exhaustion. RESULTS: Agreement analysis for V̇O(2)peak at baseline (n = 67, SCG eV̇O(2)peak: 26.9 +/- 1.9 ml.min(-1).kg(-1), V̇O(2)peak: 26.6 +/- 1.6 ml.min(-1).kg(-1), mean +/- 95% confidence interval) showed a bias of 0.3 +/- 1.0 ml.min(-1).kg(-1) with 95% limits of agreement (LoA) ranging +/- 9.8 ml.min(-1).kg(-1). A Pearson's correlation of r = 0.78 (p < 0.0001) and a standard error of estimate (SEE) of 5.0 ml.min(-1).kg(-1) were found between methods. At follow-up (n = 52), body mass was reduced by 6.6 +/- 1.4 kg (p < 0.0001). V̇O(2)peak increased by 3.3 +/- 0.9 ml.min(-1).kg(-1) and 175 +/- 78 ml.min(-1) and SCG eV̇O(2)peak by 2.6 +/- 0.8 ml.min(-1).kg(-1) and 93 +/- 76 ml.min(-1) (two-way ANOVA repeated measure: intervention p < 0.0001, method p = 0.939 and interaction p = 0.125, relative V̇O(2)peak). A Pearson's correlation of r = 0.37 (p < 0.05) was found between changes in relative V̇O(2)peak but not for absolute V̇O(2)peak r = 0.10 (p = 0.402). CONCLUSIONS: The SCG method is accurate for estimating V̇O(2)peak and appropriate for detecting group changes in both relative and absolute V̇O(2)peak following a lifestyle intervention in people with overweight and obesity. Furthermore, the method can detect individual changes in V̇O(2)peak but not independently of body mass changes. Yet, the applicability is still limited by the relatively large variation in LoA and SEE. CI - (c) 2025. The Author(s). FAU - Hansen, Mikkel Thunestvedt AU - Hansen MT AUID- ORCID: 0000-0002-3879-2192 AD - Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. mikkel.hansen@sund.ku.dk. FAU - Husted, Karina AU - Husted K AD - Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Modvig, Johanne Louise AU - Modvig JL AUID- ORCID: 0009-0008-8957-4698 AD - Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Lange, Kristine Kjaer AU - Lange KK AD - Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Weinreich, Cecilie Moe AU - Weinreich CM AUID- ORCID: 0009-0006-0531-174X AD - Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Tranberg, Cathrine AU - Tranberg C AD - Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Romer, Tue AU - Romer T AUID- ORCID: 0000-0002-3037-9344 AD - Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Ingersen, Arthur AU - Ingersen A AUID- ORCID: 0000-0001-6112-3563 AD - Xlab, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Dela, Flemming AU - Dela F AUID- ORCID: 0000-0001-9970-9535 AD - Xlab, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. AD - Laboratory of Sports and Nutrition Research, Riga Stradins University, Riga, Latvia. FAU - Helge, Jorn Wulff AU - Helge JW AUID- ORCID: 0000-0001-9724-5423 AD - Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. LA - eng SI - ClinicalTrials.gov/NCT04279366 PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250120 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 SB - IM MH - Humans MH - Female MH - Male MH - Adult MH - *Oxygen Consumption/physiology MH - Middle Aged MH - *Overweight/physiopathology/therapy MH - *Obesity/physiopathology/therapy MH - *Cardiorespiratory Fitness/physiology MH - Adolescent MH - Young Adult MH - Life Style MH - Aged MH - Body Mass Index MH - Exercise Test PMC - PMC12095068 COIS- Competing interests: MTH s PhD is financially supported by VentriJect ApS, Hellerup, Denmark. A collaboration agreement between the University of Copenhagen, Denmark, and VentriJect ApS, Hellerup, Denmark was signed prior to the study. There is no restriction on publication. EDAT- 2025/01/21 09:03 MHDA- 2025/05/22 00:28 PMCR- 2025/01/20 CRDT- 2025/01/20 23:25 PHST- 2024/05/27 00:00 [received] PHST- 2025/01/07 00:00 [accepted] PHST- 2024/12/19 00:00 [revised] PHST- 2025/05/22 00:28 [medline] PHST- 2025/01/21 09:03 [pubmed] PHST- 2025/01/20 23:25 [entrez] PHST- 2025/01/20 00:00 [pmc-release] AID - 10.1038/s41366-025-01713-9 [pii] AID - 1713 [pii] AID - 10.1038/s41366-025-01713-9 [doi] PST - ppublish SO - Int J Obes (Lond). 2025 May;49(5):864-871. doi: 10.1038/s41366-025-01713-9. Epub 2025 Jan 20. PMID- 39833387 OWN - NLM STAT- MEDLINE DCOM- 20250502 LR - 20261010 IS - 1573-3521 (Electronic) IS - 0160-7715 (Linking) VI - 48 IP - 2 DP - 2025 Apr TI - Psychometric evaluation of Liking and Wanting implicit association tests for physical activity and recreational screen use. PG - 349-359 LID - 10.1007/s10865-024-00544-9 [doi] AB - Interest in the implicit processing of activity behaviors has been growing, but the psychometric properties of its measurement are often overlooked. This study examined the reliability and validity of two implicit association tests (IATs) designed to assess implicit affective and motivational processes. In the first session, 101 college students completed a Liking-IAT, a Wanting-IAT, and a survey on their attitudes and intentions regarding physical activity and sedentary screen-based recreational activities. One week later, participants reported their engagement in these activities, and 34 of them completed the IATs again. The psychometric evaluation revealed high split-half correlation coefficients and significant correlations with behavioral attitudes and intentions for both the IATs, indicating good split-half reliability and convergent validity. The Liking IAT but not the Wanting IAT demonstrated satisfactory test-retest reliability over a one-week interval and predictive potential for weekend physical activity and screen time. Divergence in psychometric performances suggests underlying differences in corresponding implicit processes, highlighting the need for further investigation into the temporal validity, sensitivity to change, and the interplay of various implicit processes. CI - (c) 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Zhang, Youjie AU - Zhang Y AUID- ORCID: 0000-0003-4319-9809 AD - School of Public Health, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China. ujzhang@suda.edu.cn. AD - , 199 Ren Ai Road, Industrial Park, Suzhou, Jiangsu, 215123, P. R. China. ujzhang@suda.edu.cn. FAU - Lin, Jiayuan AU - Lin J AD - School of Public Health, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China. FAU - Wang, Rujin AU - Wang R AD - School of Public Health, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China. FAU - Chen, Yixuan AU - Chen Y AD - School of Public Health, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China. LA - eng GR - 82204068/National Natural Science Foundation of China/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250120 PL - United States TA - J Behav Med JT - Journal of behavioral medicine JID - 7807105 SB - IM MH - Humans MH - Female MH - Male MH - Psychometrics MH - Young Adult MH - *Exercise/psychology MH - Reproducibility of Results MH - Adult MH - *Motivation MH - *Recreation/psychology MH - Adolescent MH - Intention MH - *Screen Time MH - Students/psychology MH - Sedentary Behavior MH - Surveys and Questionnaires OTO - NOTNLM OT - Implicit processing OT - Indirect measure OT - Physical activity OT - Psychometric evaluation OT - Screen time COIS- Declarations. Ethical approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Suzhou Medical College of Soochow University (SUDA20230908H04). Consent to participate: Written informed consent was obtained from the parents. Consent for publication: Not applicable. Competing interests: The authors have no competing interests to declare that are relevant to the content of this article. EDAT- 2025/01/21 09:02 MHDA- 2025/03/23 16:52 CRDT- 2025/01/20 23:24 PHST- 2024/07/08 00:00 [received] PHST- 2024/12/10 00:00 [accepted] PHST- 2025/03/23 16:52 [medline] PHST- 2025/01/21 09:02 [pubmed] PHST- 2025/01/20 23:24 [entrez] AID - 10.1007/s10865-024-00544-9 [pii] AID - 10.1007/s10865-024-00544-9 [doi] PST - ppublish SO - J Behav Med. 2025 Apr;48(2):349-359. doi: 10.1007/s10865-024-00544-9. Epub 2025 Jan 20. PMID- 39833087 OWN - NLM STAT- MEDLINE DCOM- 20250120 LR - 20250522 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 104 IP - 3 DP - 2025 Jan 17 TI - Comparison of long-term clinical and radiologic outcomes of AperFix and fixed loop device fixation in anterior cruciate ligament reconstruction: A retrospective study. PG - e41199 LID - 10.1097/MD.0000000000041199 [doi] LID - e41199 AB - Anterior cruciate ligament reconstruction aims to improve knee stability and range of motion. The AperFix system consists of polymer components, and fixed-loop fixation is an established endoscopic technique. Our aim in this study was to compare the long-term clinical and radiological results of AperFix and fixed-loop fixation and to prove that the long-term results of the AperFix fixation method are at least as good as those of the fixed loop device. This retrospective study included 109 patients who underwent primary anterior cruciate ligament reconstruction using single bundled hamstring tendon grafts. Patients under 16 years of age, patients with incomplete follow-up, bilateral or other ligament injuries, inflammatory arthropathy, previous knee surgery, or concurrent meniscal treatment were excluded. Participants were divided into 2 groups according to femoral fixation methods: AperFix fixation (group 1, n = 55) and fixed loop device fixation (group 2, n = 54). All operations were performed by senior surgeons under general or spinal anesthesia. Postoperative rehabilitation started on day 1 and allowed patients to resume normal activities at 6 months. Outcomes were evaluated during follow-up, including knee range of motion, clinical scores [Lysholm, Cincinnati, Tegner, and International Knee Documentation Committee] and radiographic measurements of femoral tunnel width and length. Measurements were performed by 2 orthopedic surgeons to ensure reliability. This study evaluated 109 patients (55 in group 1, 54 in group 2) and found no statistically significant differences in demographic variables such as age, sex, body mass index, follow-up duration, or side distribution. Clinical outcomes, including anterior drawer test, Lachman test results, knee flexion-extension degrees, and Lysholm, Cincinnati, Tegner, and International Knee Documentation Committee scores, were similar between the groups (P > .05). Complications occurred in 8 cases (rerupture, infection, and deep vein thrombosis), with no significant correlation to the fixation method used (P = .506). Radiographic analysis revealed no significant differences in femoral tunnel width or length between the groups (P > .05). In our current study, no meaningful disparity was found between the AperFix and fixed loop device methods in terms of long-term clinical outcomes. As there are no long-term studies on the results of AperFix fixation in the literature, more studies on this subject are needed. CI - Copyright (c) 2025 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Kaya, Sehmuz AU - Kaya S AUID- ORCID: 0000-0002-9636-5260 AD - Department of Orthopaedics and Traumatology, Faculty of Medicine, Van Yuzuncu Yil University, Van, Turkey. FAU - Guven, Necip AU - Guven N AUID- ORCID: 0000-0002-0363-1524 AD - Department of Orthopaedics and Traumatology, Faculty of Medicine, Van Yuzuncu Yil University, Van, Turkey. FAU - Unal, Yunus Can AU - Unal YC AUID- ORCID: 0009-0001-6733-4211 AD - Department of Orthopaedics and Traumatology, Van Education And Research Hospital, Van, Turkey. FAU - Ozkan, Sezai AU - Ozkan S AUID- ORCID: 0000-0003-4444-6939 AD - Department of Orthopaedics and Traumatology, Faculty of Medicine, Van Yuzuncu Yil University, Van, Turkey. FAU - Adanas, Cihan AU - Adanas C AUID- ORCID: 0000-0002-3652-6077 AD - Department of Orthopaedics and Traumatology, Faculty of Medicine, Van Yuzuncu Yil University, Van, Turkey. FAU - Turkozu, Tulin AU - Turkozu T AUID- ORCID: 0000-0002-0966-9080 AD - Department of Orthopaedics and Traumatology, Faculty of Medicine, Van Yuzuncu Yil University, Van, Turkey. FAU - Danisman, Ferhat AU - Danisman F AUID- ORCID: 0000-0002-3543-0479 AD - Department of Orthopaedics and Traumatology, Van Education And Research Hospital, Van, Turkey. FAU - Ismailov, Ulan AU - Ismailov U AUID- ORCID: 0000-0003-4759-3969 AD - Department of Orthopaedics and Traumatology, Sanliurfa Education And Research Hospital, Sanliurfa, Turkey. FAU - Dundar, Abdulrahim AU - Dundar A AUID- ORCID: 0000-0003-2617-2073 AD - Department of Orthopaedics and Traumatology, Faculty of Medicine, Hitit University, Corum, Turkey. FAU - Akdemir, Zulkuf AU - Akdemir Z AUID- ORCID: 0000-0001-7958-7235 AD - Department of Radiology, Faculty of Medicine, Van Yuzuncu Yil University, Van, Turkey. FAU - Gokalp, Mehmet Ata AU - Gokalp MA AUID- ORCID: 0000-0003-0317-7365 AD - Department of Orthopaedics and Traumatology, Faculty of Medicine, Van Yuzuncu Yil University, Van, Turkey. LA - eng PT - Comparative Study PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Retrospective Studies MH - Male MH - Female MH - *Anterior Cruciate Ligament Reconstruction/methods/instrumentation MH - Adult MH - Range of Motion, Articular MH - *Anterior Cruciate Ligament Injuries/surgery MH - Treatment Outcome MH - Young Adult MH - Knee Joint/surgery/diagnostic imaging MH - Adolescent MH - Middle Aged MH - Radiography PMC - PMC11749755 COIS- The authors have no funding and conflicts of interest to disclose. EDAT- 2025/01/21 09:01 MHDA- 2025/01/21 09:02 PMCR- 2025/01/17 CRDT- 2025/01/20 22:03 PHST- 2025/01/21 09:02 [medline] PHST- 2025/01/21 09:01 [pubmed] PHST- 2025/01/20 22:03 [entrez] PHST- 2025/01/17 00:00 [pmc-release] AID - 00005792-202501170-00062 [pii] AID - MD-D-24-10974 [pii] AID - 10.1097/MD.0000000000041199 [doi] PST - ppublish SO - Medicine (Baltimore). 2025 Jan 17;104(3):e41199. doi: 10.1097/MD.0000000000041199. PMID- 39831772 OWN - NLM STAT- MEDLINE DCOM- 20250305 LR - 20261002 IS - 1531-698X (Electronic) IS - 1040-8703 (Print) IS - 1040-8703 (Linking) VI - 37 IP - 2 DP - 2025 Apr 1 TI - Utilizing preterm infant body composition assessments to guide neonatal nutrition. PG - 191-197 LID - 10.1097/MOP.0000000000001434 [doi] AB - PURPOSE OF REVIEW: The use of body composition to assess the quality of infant growth may add valuable information to pediatric clinical care. Preterm infants have differences in their fat and muscle mass development compared with infants born at term, which may be related to their early nutritional exposures. This review focuses on recent studies examining early nutrition in preterm infants and related body composition outcomes in the newborn period and beyond. RECENT FINDINGS: Overall, the evidence shows that early nutrient delivery in parenteral nutrition and through formula supplementation or human milk fortification is associated with increased fat-free mass or lean mass in early life. However, future research is needed to fully understand the link between these body composition changes and longitudinal outcomes in preterm infants. SUMMARY: Inclusion of body composition assessments in preterm infant nutrition research is critical to understand the factors associated with differences in adiposity and lean mass development in preterm infants. Medical fragility in preterm infants limits the routine use of body composition assessment tools which are currently validated, and additional studies are needed to thoroughly assess other methods which may be more feasible to integrate into bedside routine. CI - Copyright (c) 2025 Wolters Kluwer Health, Inc. All rights reserved. FAU - Buck, Catherine O AU - Buck CO AD - Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA. LA - eng GR - K23 HD104907/HD/NICHD NIH HHS/United States PT - Journal Article PT - Review DEP - 20250102 PL - United States TA - Curr Opin Pediatr JT - Current opinion in pediatrics JID - 9000850 SB - IM MH - Humans MH - *Body Composition/physiology MH - Infant, Newborn MH - *Infant, Premature/growth & development MH - *Infant Nutritional Physiological Phenomena MH - Parenteral Nutrition/methods MH - Infant Formula MH - Milk, Human PMC - PMC11882371 MID - NIHMS2042112 COIS- Conflicts of interest The authors declare no conflicts of interest EDAT- 2025/01/20 22:55 MHDA- 2025/03/05 06:22 PMCR- 2026/04/01 CRDT- 2025/01/20 09:03 PHST- 2025/03/05 06:22 [medline] PHST- 2025/01/20 22:55 [pubmed] PHST- 2025/01/20 09:03 [entrez] PHST- 2026/04/01 00:00 [pmc-release] AID - 00008480-202504000-00011 [pii] AID - 10.1097/MOP.0000000000001434 [doi] PST - ppublish SO - Curr Opin Pediatr. 2025 Apr 1;37(2):191-197. doi: 10.1097/MOP.0000000000001434. Epub 2025 Jan 2. PMID- 39828262 OWN - NLM STAT- MEDLINE DCOM- 20250502 LR - 20250528 IS - 1440-6047 (Electronic) IS - 0964-7058 (Print) IS - 0964-7058 (Linking) VI - 34 IP - 1 DP - 2025 Feb TI - Associations between diet quality scores and cardiometabolic status in young Japanese women: A cross-sectional study. PG - 91-103 LID - 10.6133/apjcn.202502_34(1).0009 [doi] AB - BACKGROUND AND OBJECTIVES: This cross-sectional study aimed to examine associations between diet quality scores and adverse cardiometabolic status in young Japanese women. METHODS AND STUDY DESIGN: In total, 1084 female dietetics students aged 18-22 years completed a validated self-administered diet history questionnaire. Diet quality was assessed using the Diet Quality Score for Japanese (DQSJ), Healthy Eating Index-2015 (HEI-2015), Alternate Healthy Eating Index-2010 (AHEI-2010), Alternate Mediterranean Diet score (AMED), Dietary Approaches to Stop Hypertension score (DASH), and Japanese Food Guide Spinning Top score (JFGST). Adverse cardiometabolic status was defined as the highest quartile of the sum of z scores for waist circumference, systolic and diastolic blood pressure, high-density lipoprotein cholesterol (multiplied by -1), triacylglycerol, glucose, and insulin. RESULTS: After adjustment for potential confounding factors, adverse cardiometabolic status was significantly associated with all the diet quality scores except for AMED, with adjusted odds ratios (95% confidence interval) in the highest quartile compared with the lowest of 0.39 (0.25-0.61) for DQSJ, 0.40 (0.26-0.61) for DASH, 0.44 (0.30-0.66) for AHEI-2010, 0.59 (0.39-0.88) for HEI-2015, 0.67 (0.45-0.99) for JFGST, and 0.80 (0.54-1.18) for AMED. Associations with each of the cardiometabolic risk factors were most prominent for AHEI-2010 (significant associations with all factors except triacylglycerol), followed by DQSJ (significant associations with all factors except triacylglycerol and glucose). CONCLUSIONS: This cross-sectional study of young Japanese women showed associations between several diet quality scores and cardiometabolic status. These associations should be confirmed in other populations, prospectively where possible. FAU - Oono, Fumi AU - Oono F AD - Department of Social and Preventive Epidemiology, Division of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. AD - Department of Epidemiology and Preventive Medicine, Graduate School of Medicine, Gifu University, Gifu, Japan. FAU - Murakami, Kentaro AU - Murakami K AD - Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo, Japan. Email: kenmrkm@m.u-tokyo.ac.jp. FAU - Uenishi, Kazuhiro AU - Uenishi K AD - Laboratory of Physiological Nutrition, Kagawa Nutrition University, Saitama, Japan. FAU - Fujiwara, Aya AU - Fujiwara A AD - Division of Food Safety Information, National Institute of Health Sciences, Kanagawa, Japan. AD - Department of Nutritional Epidemiology and Shokuiku, National Institute of Biomedical Innovation, Health and Nutrition, Osaka, Japan. FAU - Shinozaki, Nana AU - Shinozaki N AD - Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo, Japan. FAU - Sasaki, Satoshi AU - Sasaki S AD - Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo, Japan. CN - Japan Dietetic Students' Study for Nutrition and Biomarkers Group LA - eng GR - 21J22440/Japan Society for the Promotion of Science/ GR - 200400526A/Ministry of Health, Labour and Welfare of Japan/ GR - 200500555A/Ministry of Health, Labour and Welfare of Japan/ GR - 200624013A/Ministry of Health, Labour and Welfare of Japan/ GR - 200624013B/Ministry of Health, Labour and Welfare of Japan/ PT - Journal Article PL - China TA - Asia Pac J Clin Nutr JT - Asia Pacific journal of clinical nutrition JID - 9440304 RN - 0 (Triglycerides) SB - IM MH - Adolescent MH - Female MH - Humans MH - Young Adult MH - Cardiometabolic Risk Factors MH - *Cardiovascular Diseases/epidemiology MH - Cross-Sectional Studies MH - *Diet/standards MH - Japan/epidemiology MH - Triglycerides/blood PMC - PMC11742597 OTO - NOTNLM OT - Japan OT - cardiovascular disease risk OT - metabolic syndrome OT - diet quality indices OT - dietary pattern COIS- The authors declare no conflict of interest. EDAT- 2025/01/20 22:51 MHDA- 2025/01/20 22:52 PMCR- 2024/12/01 CRDT- 2025/01/19 20:02 PHST- 2025/01/20 22:52 [medline] PHST- 2025/01/20 22:51 [pubmed] PHST- 2025/01/19 20:02 [entrez] PHST- 2024/12/01 00:00 [pmc-release] AID - 10.6133/apjcn.202502_34(1).0009 [doi] PST - ppublish SO - Asia Pac J Clin Nutr. 2025 Feb;34(1):91-103. doi: 10.6133/apjcn.202502_34(1).0009. PMID- 39827945 OWN - NLM STAT- MEDLINE DCOM- 20250305 LR - 20260530 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 207 DP - 2025 Mar 1 TI - Nutri-score label influence on food purchase intention depends on consumers' expectations of healthiness. PG - 107870 LID - S0195-6663(25)00022-4 [pii] LID - 10.1016/j.appet.2025.107870 [doi] AB - Front-of-Package (FOP) nutrition labels are designed to convey the healthiness of food products and help consumers make healthier choices. This research examines how French consumers' responses to a FOP nutrition label-Nutri-Score-are influenced by their initial expectations regarding the overall healthiness of products. Based on expectancy-disconfirmation theory, we hypothesize that when products have a worse-than-expected Nutri-Score, the display of the FOP label will enhance guilt perception and reduce purchase intention. Conversely, when products have a better-than-expected score, the label display will diminish guilt perception and increase purchase intention. A pilot study, two controlled lab experiments, and one field study test our proposition. While in Studies 1 and 2 participants were randomly assigned to the label conditions (Nutri-Score vs. control), the prior expectations of healthiness were a non-randomized factor (Studies: Pilot, 1, and 2). Study 1 (N = 128) validates our proposition with judgments of an unhealthy food item (Nutri-Score-D). Study 2 (N = 147) extends these findings to both healthy and unhealthy food products. When the Nutri-Score grade was better-than-expected, it reduced guilt and boosted purchase intention, even for low nutritional quality foods (Nutri-Score-D). Conversely, a worse-than-expected Nutri-Score increased guilt and lowered purchase intention, even for healthier products (Nutri-Score-B). A field study (1680 sales) suggests that including the Nutri-Score label to products sold in a cafeteria can increase the sales of products labeled D. We show that a nutrition label may, in some cases, increase purchase intentions of unhealthy products and decrease purchase intentions of healthy ones. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Yamim, Amanda P AU - Yamim AP AD - Grenoble Ecole de Management, 38000, Grenoble, France; Universite de Savoie Montblanc (IREGE), Annecy, France. Electronic address: amanda.pruskiyamim@grenoble-em.com. FAU - Werle, Carolina O C AU - Werle COC AD - Grenoble Ecole de Management, 38000, Grenoble, France; Universite de Savoie Montblanc (IREGE), Annecy, France. Electronic address: Carolina.werle@grenoble-em.com. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20250117 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - *Food Labeling MH - *Consumer Behavior MH - Female MH - Male MH - Adult MH - *Intention MH - *Food Preferences/psychology MH - *Nutritive Value MH - Pilot Projects MH - *Diet, Healthy/psychology MH - Choice Behavior MH - Young Adult MH - Middle Aged MH - France MH - Guilt MH - Adolescent OTO - NOTNLM OT - Expectancy disconfirmation OT - FOP evaluative labels OT - Food purchase intention OT - Nutrition labeling OT - Product evaluation COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/01/20 22:52 MHDA- 2025/03/06 05:06 CRDT- 2025/01/19 19:14 PHST- 2024/09/02 00:00 [received] PHST- 2025/01/15 00:00 [revised] PHST- 2025/01/15 00:00 [accepted] PHST- 2025/03/06 05:06 [medline] PHST- 2025/01/20 22:52 [pubmed] PHST- 2025/01/19 19:14 [entrez] AID - S0195-6663(25)00022-4 [pii] AID - 10.1016/j.appet.2025.107870 [doi] PST - ppublish SO - Appetite. 2025 Mar 1;207:107870. doi: 10.1016/j.appet.2025.107870. Epub 2025 Jan 17. PMID- 39827352 OWN - NLM STAT- MEDLINE DCOM- 20250502 LR - 20250815 IS - 2072-1315 (Electronic) IS - 1606-0997 (Print) IS - 1606-0997 (Linking) VI - 44 IP - 1 DP - 2025 Jan 18 TI - The association of dietary approaches to stop hypertension measured by the food frequency questionnaire with metabolic syndrome and some inflammatory biomarkers in adolescents with obesity: a case-control study. PG - 12 LID - 10.1186/s41043-025-00744-2 [doi] LID - 12 AB - BACKGROUND: Globally, obesity trends are a serious public health concern. Adolescent obesity is associated with cardiometabolic risk and metabolic disorders in adolescence and may persist into adulthood. The current study was designed to explore the Dietary Approaches to Stop Hypertension (DASH) in adolescents and its relationship with obesity, insulin resistance, metabolic syndrome (MetS), and some inflammatory biomarkers. METHODS: A total of 90 adolescents with obesity and 90 adolescents with normal weight, participated in the study. Data from a validated 168-item semi-quantitative food frequency questionnaire were used to calculate the DASH score. The association of DASH score with cardiometabolic risk factors was estimated using multivariable logistic regression models. To assess the correlation between the DASH score and dietary factor, the Pearson correlation coefficient (r) was used. RESULTS: Adolescents with a high DASH score had significantly higher intakes of potassium, magnesium, vitamin C, and vitamin K and lower intakes of sodium compared with those with a low DASH score (P < 0.05 ). There were no significant differences in the DASH score and its components between adolescents with and without metabolic syndrome. Adolescents with metabolic syndrome had significantly higher concentrations of triglycerides, low HDL-C, and high blood pressure compared with those without metabolic syndrome (P < 0.05). There were no significant associations between DASH score and MetS and other cardiometabolic risk factors in crude and multivariate-adjusted models. In addition, the DASH score was positively associated with potassium, magnesium, sodium, vitamins D and C, docosahexaenoic acid, and soluble fiber (P < 0.05). CONCLUSION: In the current study, there was no significant association between adherence to the DASH diet and odds of metabolic syndrome, and other cardiometabolic risk factors in adolescent. Further prospective studies are needed to confirm these findings. TRIAL REGISTRATION: Ethics approval was obtained from the research ethics committee of Tabriz University of Medical Sciences (IR.TBZMED.REC.1397.179.). CI - (c) 2025. The Author(s). FAU - Behrooz, Maryam AU - Behrooz M AD - Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. mm.behroozp@gmail.com. AD - Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. mm.behroozp@gmail.com. FAU - Ostadrahimi, Alireza AU - Ostadrahimi A AD - Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. FAU - Hajjarzadeh, Samaneh AU - Hajjarzadeh S AD - Student of Nutrition Sciences, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. FAU - Mousavi, Mirhadi AU - Mousavi M AD - Pediatric Department Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. FAU - Behbahani, Afshin Ghalegolab AU - Behbahani AG AD - Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. FAU - Shiva, Siamak AU - Shiva S AD - Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. shivasiamak@yahoo.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250118 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Metabolic Syndrome/blood/epidemiology MH - Adolescent MH - Female MH - Male MH - Biomarkers/blood MH - *Pediatric Obesity/blood/complications/epidemiology MH - *Dietary Approaches To Stop Hypertension/statistics & numerical data MH - Case-Control Studies MH - *Inflammation/blood MH - Surveys and Questionnaires MH - Cardiometabolic Risk Factors MH - *Hypertension MH - Risk Factors MH - Insulin Resistance MH - Diet Surveys PMC - PMC11742523 OTO - NOTNLM OT - Adolescent OT - Dietary approaches to stop hypertension OT - Insulin resistance OT - Metabolic syndrome OT - Obesity OT - Overweight COIS- Declarations. Ethics approval and consent to participate: Ethics approval was obtained from the research ethics committee of Tabriz University of Medical Sciences (IR.TBZMED.REC.1397.179.). The ethical standards of the institutional and/or national research committee and the Helsinki Declaration of 1964 and its subsequent amendments or comparable ethical standards were followed for all procedures in studies involving human participants. Informed consent was obtained from all subjects or their parents on behalf of the participants. The purpose of the study was explained to the participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/01/20 22:54 MHDA- 2025/01/20 22:55 PMCR- 2025/01/18 CRDT- 2025/01/18 23:23 PHST- 2024/08/04 00:00 [received] PHST- 2025/01/06 00:00 [accepted] PHST- 2025/01/20 22:55 [medline] PHST- 2025/01/20 22:54 [pubmed] PHST- 2025/01/18 23:23 [entrez] PHST- 2025/01/18 00:00 [pmc-release] AID - 10.1186/s41043-025-00744-2 [pii] AID - 744 [pii] AID - 10.1186/s41043-025-00744-2 [doi] PST - epublish SO - J Health Popul Nutr. 2025 Jan 18;44(1):12. doi: 10.1186/s41043-025-00744-2. PMID- 39825983 OWN - NLM STAT- MEDLINE DCOM- 20250501 LR - 20250528 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 30 IP - 1 DP - 2025 Jan 18 TI - The risk of believing that emotions are bad and uncontrollable: association with orthorexia nervosa. PG - 8 LID - 10.1007/s40519-024-01710-3 [doi] LID - 8 AB - PURPOSE: This study aimed to explore emotional functioning in individuals with varying levels of orthorexia nervosa (ON) symptoms. Given the established links between emotion dysregulation and other eating disorders (EDs), and the conceptualization of ON within the ED spectrum, this research sought to examine the relationships between ON symptomatology and emotion regulation strategies, alexithymia, and beliefs about emotions. METHODS: A large sample (N = 562) completed self-report measures with high psychometric properties, assessing ON traits (E-DOS), emotion regulation strategies (DERS-SF and ERQ), alexithymia (TAS-20), and beliefs about emotions (ERQ). The study used well-validated measures to address limitations of previous research. RESULTS: Individuals with high ON traits demonstrated difficulties in most aspects of emotional functioning compared to those with low ON traits. Suppression, but not reappraisal, partially mediated the relationship between beliefs about emotions and ON symptoms. Believing emotions are bad or useless, difficulty controlling impulses, and relying on suppression to regulate emotions were most strongly associated with ON symptoms. CONCLUSION: This study provides evidence that emotion dysregulation plays an important role in ON symptomatology. The findings suggest that when emotions feel unhelpful or uncontrollable, and maladaptive strategies like suppression are employed, individuals may seek perceived control through pathologically 'healthy' eating. There is currently no diagnosis criteria for ON, and consequently no clear treatment pathway. Our research suggests that specific aspects of emotional functioning such as beliefs about the usefulness of emotions or difficulties with feeling out of control when upset may be a useful treatment target to help individuals with ON develop healthier coping mechanisms and reduce reliance on rigid dietary rules as a means of emotional regulation. LEVEL III: Evidence obtained from well-designed cohort or case-control analytic studies. CI - (c) 2024. The Author(s). FAU - Vuillier, L AU - Vuillier L AUID- ORCID: 0000-0001-6502-0676 AD - Faculty of Science and Technology, Department of Psychology, Bournemouth University, Poole, UK. lrenshawvuillier@bournemouth.ac.uk. FAU - Greville-Harris, M AU - Greville-Harris M AUID- ORCID: 0000-0001-8191-9614 AD - Faculty of Science and Technology, Department of Psychology, Bournemouth University, Poole, UK. FAU - Moseley, R L AU - Moseley RL AUID- ORCID: 0000-0002-5985-6175 AD - Faculty of Science and Technology, Department of Psychology, Bournemouth University, Poole, UK. LA - eng PT - Journal Article DEP - 20250118 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM EIN - Eat Weight Disord. 2025 May 28;30(1):44. doi: 10.1007/s40519-025-01750-3. PMID: 40437294 MH - Humans MH - Female MH - *Feeding and Eating Disorders/psychology MH - Adult MH - *Emotions/physiology MH - Young Adult MH - *Affective Symptoms/psychology MH - Male MH - *Emotional Regulation/physiology MH - *Feeding Behavior/psychology MH - Adolescent MH - Middle Aged MH - Self Report PMC - PMC11742882 OTO - NOTNLM OT - Beliefs OT - Controllability OT - Eating disorder OT - Emotion regulation OT - Orthorexia nervosa COIS- Declarations. Ethics approval and consent to participate: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Bournemouth University (Date 22/07/2022; No 45304). Informed consent was obtained from all individual participants included in the study. Consent for publication: Consent to publish has been received from all participants. Competing interests: The authors declare no competing interests. EDAT- 2025/01/18 15:22 MHDA- 2025/01/18 15:23 PMCR- 2025/01/18 CRDT- 2025/01/18 11:17 PHST- 2024/08/02 00:00 [received] PHST- 2024/12/15 00:00 [accepted] PHST- 2025/01/18 15:23 [medline] PHST- 2025/01/18 15:22 [pubmed] PHST- 2025/01/18 11:17 [entrez] PHST- 2025/01/18 00:00 [pmc-release] AID - 10.1007/s40519-024-01710-3 [pii] AID - 1710 [pii] AID - 10.1007/s40519-024-01710-3 [doi] PST - epublish SO - Eat Weight Disord. 2025 Jan 18;30(1):8. doi: 10.1007/s40519-024-01710-3. PMID- 39825961 OWN - NLM STAT- MEDLINE DCOM- 20250806 LR - 20261010 IS - 1432-0460 (Electronic) IS - 0179-051X (Linking) VI - 40 IP - 4 DP - 2025 Aug TI - A New Instrument to Define Parental Fear Regarding Feeding Their Children: A Reliability and Validity Study. PG - 1008-1021 LID - 10.1007/s00455-024-10800-4 [doi] AB - This study aimed to develop the 'Fear of Feeding My Child- A Parental Report (FF-PR)', which measures the parental fear of feeding their children, and to determine its reliability and validity. The study consists of the developmental phase and reported the content validity, internal consistency, test-retest reliability, construct, criterion, and discriminant validity. The study included two groups; 'Group I (N = 90)' who had a neurological disorder and their parents, and 'Group II (N = 60)' who were typically developing children without any feeding and swallowing problems and their parents. Limited literature review, clinical experience, and parental interviews have been used in creating the item pool. A panel of 7 experts assessed the content validity in two Delphi rounds. Cronbach's alpha measured the internal consistency of each item. The test-retest reliability was determined using the FF-PR scores given by the parents in Group I one week apart. Confirmatory factor analysis was used to measure the construct validity. The Nordic Orofacial Screening Test (NOT-S), Dysphagia Disorder Survey (DDS), and the Turkish version of the Feeding-Swallowing Impact Survey (T-FS-IS) were used for the criterion validity of the FF-PR. The discriminant validity of the FF-PR was determined by comparing the FF-PR scores of the groups and using the receiver-operating characteristic (ROC) curve. The content validity index was 0.92. The Cronbach's alpha was found to be high (test: 0.966, retest: 0.969). The FF-PR had an excellent chi-square fit (chi(2)/df = 123.075/127 p = 0.582) and according to the fit indices; the FF-PR was found to have a good fit. There was a low-moderate correlation between FF-PR and NOT-S (r = 0.335 - 0.462, p < 0.001) and DDS (r = 0.461 - 0.535, p < 0.001) and a moderate-high correlation between FF-PR and T-FS-IS (r = 0.501 - 0.807, p < 0.001). The FF-PR total and subscale scores were higher in Group I than in Group II. In conclusion, the FF-PR scale is a valid and reliable tool for measuring parental fear about feeding their child. CI - (c) 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Yesilkus, Rabia AU - Yesilkus R AUID- ORCID: 0000-0001-6557-779X AD - Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey. rabiayesilkuss@gmail.com. FAU - Serel Arslan, Selen AU - Serel Arslan S AUID- ORCID: 0000-0002-2463-7503 AD - Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey. LA - eng PT - Journal Article PT - Validation Study DEP - 20250118 PL - United States TA - Dysphagia JT - Dysphagia JID - 8610856 SB - IM MH - Humans MH - Reproducibility of Results MH - *Parents/psychology MH - Male MH - Female MH - *Fear/psychology MH - Surveys and Questionnaires MH - Child MH - Child, Preschool MH - *Deglutition Disorders/psychology MH - Psychometrics MH - Adult MH - *Feeding Behavior/psychology MH - Delphi Technique MH - Turkey OTO - NOTNLM OT - Anxiety OT - Fear OT - Feeding difficulty OT - Parents OT - Swallowing difficulty COIS- Declarations. Conflict of interest: The authors declare that they have no conflict of interest. Ethical Approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed Consent: Informed consent was obtained from children and their parents who participated in this study. EDAT- 2025/01/18 15:22 MHDA- 2025/08/06 12:28 CRDT- 2025/01/18 11:16 PHST- 2024/01/18 00:00 [received] PHST- 2024/12/30 00:00 [accepted] PHST- 2025/08/06 12:28 [medline] PHST- 2025/01/18 15:22 [pubmed] PHST- 2025/01/18 11:16 [entrez] AID - 10.1007/s00455-024-10800-4 [pii] AID - 10.1007/s00455-024-10800-4 [doi] PST - ppublish SO - Dysphagia. 2025 Aug;40(4):1008-1021. doi: 10.1007/s00455-024-10800-4. Epub 2025 Jan 18. PMID- 39825639 OWN - NLM STAT- MEDLINE DCOM- 20250206 LR - 20250610 IS - 1466-447X (Electronic) IS - 0264-0414 (Linking) VI - 42 IP - 24 DP - 2024 Dec TI - Development and initial validation of the group exercise motivation scale and associated factors in an Asian population. PG - 2572-2581 LID - 10.1080/02640414.2025.2453341 [doi] AB - BACKGROUNDS: Physical activity is crucial in health promotion. Exercise in groups can strengthen the benefits of exercise itself. However, the scale measuring the motivation for group exercise is scare. AIM: To develop and preliminarily validate the Group Exercise Motivation Scale (GEMS) in a global Asian population. METHODS: A total of 1021 participants from seven regions across the world were recruited. Based on the theory of planned behavior, we developed an initial 20-item scale for the measurement of group exercise motivation and conducted an exploratory factor analysis (EFA). Then, a confirmatory factor analysis (CFA) was performed to replicate the factor structure obtained through EFA with a refined 15-item scale, among 510 and 511 participants, respectively. RESULTS: Four dimensions have been derived including personal attitude, subjective norms, perceived behavioral control, and behavioral intention. The GEMS showed acceptable factorial validity, satisfactory reliability (Cronbach's alpha 0.779 and McDonald's omega 0.745), and no floor/ceiling effect. The scale was developed in Chinese language. CONCLUSIONS: The GEMS has utility as an assessment for group exercise motivation. This study provides evidence for future longitudinal studies to evaluate the effectiveness of group exercise in the field of public health. FAU - Liu, Yuanfei AU - Liu Y AD - School of Nursing, University of Pennsylvania, Philadelphia, PA, USA. FAU - Liu, Jianghong AU - Liu J AD - School of Nursing, University of Pennsylvania, Philadelphia, PA, USA. LA - eng PT - Journal Article PT - Validation Study DEP - 20250118 PL - England TA - J Sports Sci JT - Journal of sports sciences JID - 8405364 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - *Exercise/psychology MH - Factor Analysis, Statistical MH - *Group Processes MH - Intention MH - *Motivation MH - Psychometrics MH - Reproducibility of Results MH - Surveys and Questionnaires MH - *Asian/psychology OTO - NOTNLM OT - Global OT - Group exercise OT - Motivation OT - Scale OT - Virtual EDAT- 2025/01/18 15:10 MHDA- 2025/02/06 12:22 CRDT- 2025/01/18 03:32 PHST- 2025/02/06 12:22 [medline] PHST- 2025/01/18 15:10 [pubmed] PHST- 2025/01/18 03:32 [entrez] AID - 10.1080/02640414.2025.2453341 [doi] PST - ppublish SO - J Sports Sci. 2024 Dec;42(24):2572-2581. doi: 10.1080/02640414.2025.2453341. Epub 2025 Jan 18. PMID- 39824886 OWN - NLM STAT- MEDLINE DCOM- 20250501 LR - 20250604 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Jan 17 TI - Physical and emotional abuse with internet addiction and anxiety as a mediator and physical activity as a moderator. PG - 2305 LID - 10.1038/s41598-025-85943-x [doi] LID - 2305 AB - This study aimed to explore the relationship between physical and emotional abuse (physical-emotional abuse) and Internet addiction in university students, as well as the mediating role of anxiety and the moderating role of physical activity. The data of physical-emotional abuse, anxiety and Internet addiction, and physical activity were measured by subjective questionnaire with convenience sampling in March 2024. A total of 1591 participants (806 males and 692 females) from Shanxi, Henan, Hunan and Hubei provinces in China were investigated. Subsequently, the relationships among the variables were explored using pearson correlation analysis. Finally, mediation and moderation models were assessed using the SPSS PROCESS macro plugin. After controlling for participants' gender, grade level, and place of residence, only-child status, the study findings revealed that physical-emotional abuse significantly and positively predicted internet addiction and anxiety among university students (beta = 0.157, beta = 0.271, p < 0.001). However, upon the inclusion of anxiety as a variable, the predictive effect of physical-emotional abuse on internet addiction among university students became non-significant (beta = 0.035, p > 0.05). Anxiety was found to have a significant complete mediating effect between physical-emotional abuse and internet addiction among university students. Additionally, physical activity significantly and negatively predicted anxiety (beta = -0.062, p < 0.05), and the interaction term between physical-emotional abuse and physical activity also significantly and negatively predicted anxiety (beta = - 0.053, p < 0.05). Physical activity moderated the first half of the mediation pathway from "physical-emotional abuse to anxiety to internet addiction." Anxiety may be the internal mechanism of physical-emotional abuse affecting university students' Internet addiction, and physical activity plays a moderator role in the relationship between physical-emotional abuse and university students' Internet addiction. The study will provide new perspectives and strategies for the public health field to address physical-emotional abuse and Internet addiction among university students. It is also critical that future studies validate these findings on a large, multi-country basis. CI - (c) 2025. The Author(s). FAU - Peng, Jinyin AU - Peng J AD - School of Sports Science, Jishou University, Jishou, China. FAU - Liu, Yang AU - Liu Y AD - School of Sports Science, Jishou University, Jishou, China. ldyedu@foxmail.com. FAU - Wang, Xubo AU - Wang X AD - School of Sports Science, Jishou University, Jishou, China. FAU - Yi, Zhenxiu AU - Yi Z AD - Chengdu Sport University, Chengdu, China. FAU - Xu, Lei AU - Xu L AD - School of Sports Science, Jishou University, Jishou, China. AD - Institute of Physical Education, Shanxi University of Finance and Economics, Taiyuan, China. FAU - Zhang, Fulan AU - Zhang F AD - School of Sports Science, Jishou University, Jishou, China. jdzhangtiancheng@163.com. LA - eng PT - Journal Article DEP - 20250117 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Male MH - Female MH - *Internet Addiction Disorder/psychology/epidemiology MH - *Exercise/psychology MH - *Anxiety/psychology/epidemiology MH - Young Adult MH - Students/psychology MH - Surveys and Questionnaires MH - China/epidemiology MH - *Emotional Abuse/psychology MH - Adult MH - Adolescent MH - Universities MH - *Behavior, Addictive/psychology MH - Internet MH - *Physical Abuse/psychology PMC - PMC11742654 OTO - NOTNLM OT - Anxiety OT - Internet addiction OT - Physical activity OT - Physical-emotional abuse OT - University student COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Biomedicine Ethics Committee of Jishou University before the initiation of the project (Grant number: JSDX-2024-0086). Prior to the commencement of the investigation, all subjects voluntarily participated with informed consent and signed a written informed consent form. Competing interests: The authors declare no competing interests. EDAT- 2025/01/18 15:10 MHDA- 2025/01/18 15:11 PMCR- 2025/01/17 CRDT- 2025/01/17 23:17 PHST- 2024/07/24 00:00 [received] PHST- 2025/01/07 00:00 [accepted] PHST- 2025/01/18 15:11 [medline] PHST- 2025/01/18 15:10 [pubmed] PHST- 2025/01/17 23:17 [entrez] PHST- 2025/01/17 00:00 [pmc-release] AID - 10.1038/s41598-025-85943-x [pii] AID - 85943 [pii] AID - 10.1038/s41598-025-85943-x [doi] PST - epublish SO - Sci Rep. 2025 Jan 17;15(1):2305. doi: 10.1038/s41598-025-85943-x. PMID- 39824224 OWN - NLM STAT- MEDLINE DCOM- 20250501 LR - 20260530 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 207 DP - 2025 Mar 1 TI - Appetite and childhood malnutrition: A narrative review identifying evidence gaps between clinical practice and research. PG - 107866 LID - S0195-6663(25)00018-2 [pii] LID - 10.1016/j.appet.2025.107866 [doi] AB - Severe Acute Malnutrition (SAM) is a critical global health issue, contributing to approximately one-half of all child mortality worldwide. SAM management guidelines recommend the use of appetite assessment determined by an "appetite test" to distinguish between complicated and uncomplicated SAM, subsequently guiding clinical decisions regarding outpatient versus inpatient care and discharge from hospital. Despite the widespread utilization of this recommendation, its validity lacks substantial evidence within the existing literature. Hence, the aims of this narrative review were to provide an overview of the SAM diagnostic and management guideline recommendations concerning the use of appetite assessment; to review the existing knowledge base supporting this clinical practice. The review identified gaps between the clinical use of appetite assessment in SAM management and the available supporting scientific evidence. Additionally, both the opportunities and challenges associated with appetite assessment methods used in clinical practice were highlighted and discussed in relation to existing literature. Further studies with more rigorous methods are needed to bridge these gaps and formulate evidence-based clinical practice. There is also a need to adapt and validate the existing appetite assessment tools to ensure they are tailored to the specific population, setting, and primary purpose of assessing appetite in children who have already developed SAM. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Toni, Alemayehu Teklu AU - Toni AT AD - Department of Pediatrics and Child Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; Human Nutrition and Health, Wageningen University and Research, Wageningen, the Netherlands. Electronic address: alemayehutoni@gmail.com. FAU - Girma, Tsinuel AU - Girma T AD - Department of Pediatrics and Child Health, Faculty of Medical Science, Jimma University, Jimma, Ethiopia. FAU - Hetherington, Marion M AU - Hetherington MM AD - School of Psychology, University of Leeds, Leeds, UK. FAU - Gonzales, Gerard Bryan AU - Gonzales GB AD - Human Nutrition and Health, Wageningen University and Research, Wageningen, the Netherlands; Department of Public Health and Primary Care, Faculty of Medicine and Health Science, Ghent University, Ghent, Belgium. FAU - Forde, Ciaran G AU - Forde CG AD - Human Nutrition and Health, Wageningen University and Research, Wageningen, the Netherlands. LA - eng PT - Journal Article PT - Review DEP - 20250115 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - *Appetite MH - Child MH - *Nutrition Assessment MH - *Severe Acute Malnutrition/diagnosis/therapy MH - *Child Nutrition Disorders/diagnosis/therapy MH - Child, Preschool MH - Practice Guidelines as Topic MH - Evidence Gaps OTO - NOTNLM OT - Appetite OT - Child OT - Infant OT - Malnutrition OT - Severe acute malnutrition COIS- Declaration of competing interest There is no conflict of interest for this review. EDAT- 2025/01/18 15:10 MHDA- 2025/03/06 05:03 CRDT- 2025/01/17 19:13 PHST- 2024/07/23 00:00 [received] PHST- 2024/12/22 00:00 [revised] PHST- 2025/01/13 00:00 [accepted] PHST- 2025/03/06 05:03 [medline] PHST- 2025/01/18 15:10 [pubmed] PHST- 2025/01/17 19:13 [entrez] AID - S0195-6663(25)00018-2 [pii] AID - 10.1016/j.appet.2025.107866 [doi] PST - ppublish SO - Appetite. 2025 Mar 1;207:107866. doi: 10.1016/j.appet.2025.107866. Epub 2025 Jan 15. PMID- 39822201 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250129 IS - 2590-1095 (Electronic) IS - 2590-1095 (Linking) VI - 6 IP - 4 DP - 2024 Dec TI - Psychometrics of Wearable Devices Measuring Physical Activity in Ambulant Children With Gait Abnormalities: A Systematic Review and Meta-analysis. PG - 100384 LID - 10.1016/j.arrct.2024.100384 [doi] LID - 100384 AB - OBJECTIVE: To evaluate psychometrics of wearable devices measuring physical activity (PA) in ambulant children with gait abnormalities due to neuromuscular conditions. DATA SOURCES: We searched PubMed, Embase, PsycINFO, CINAHL, and SPORTDiscus in March 2023. STUDY SELECTION: We included studies if (1) participants were ambulatory children (2-19y) with gait abnormalities, (2) reliability and validity were analyzed, and (3) peer-reviewed studies in the English language and full-text were available. We excluded studies of children with primarily visual conditions, behavioral diagnoses, or primarily cognitive disability. We performed independent screening and inclusion, data extraction, assessment of the data, and grading of results with 2 researchers. DATA EXTRACTION: Our report follows Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We assessed methodological quality with Consensus-based Standards for the selection of health measurement instruments. We extracted data on reported reliability, measurement error, and validity. We performed meta-analyses for reliability and validity coefficient values. DATA SYNTHESIS: Of 6911 studies, we included 26 with 1064 participants for meta-analysis. Results showed that wearables measuring PA in children with abnormal gait have high to very high reliability (intraclass correlation coefficient [ICC](+, test-retest reliability)=0.81; 95% confidence interval [CI], 0.74-0.89; I (2)=88.57%; ICC(+, interdevice reliability)=0.99; 95% CI, 0.98-0.99; I (2)=71.01%) and moderate to high validity in a standardized setting (r (+, construct validity)=0.63; 95% CI, 0.36-0.89; I (2)=99.97%; r (+, criterion validity)=0.68; 95% CI, 0.57-0.79; I (2)=98.70%; r (+, criterion validity cutoff) (point based)=0.69; 95% CI, 0.58-0.80; I (2)=87.02%). The methodological quality of all studies included in the meta-analysis was moderate. CONCLUSIONS: There was high to very high reliability and moderate to high validity for wearables measuring PA in children with abnormal gait, primarily due to neurological conditions. Clinicians should be aware that several moderating factors can influence an assessment. CI - (c) 2024 The Authors. FAU - van Moorsel, Huib AU - van Moorsel H AD - Institute for Human Movement Studies, University of Applied Sciences, Utrecht, The Netherlands. FAU - Engels, Barbara AU - Engels B AD - Research Centre Healthy and Sustainable Living, Research group Lifestyle and Health, Utrecht University of Applied Sciences, Utrecht, The Netherlands. AD - University Medical Center Utrecht Brain Center and Center of Excellence for Rehabilitation Medicine, Utrecht University, Utrecht, The Netherlands. FAU - Buczny, Jacek AU - Buczny J AD - Faculty of Behavioral and Movement Sciences, Department of Experimental and Applied Psychology, Amsterdam University Medical Center, Amsterdam, The Netherlands. FAU - Gorter, Jan Willem AU - Gorter JW AD - Department of Rehabilitation, Physical Therapy Science and Sports, University Medical Center Utrecht Brain Center, Utrecht, The Netherlands. AD - CanChild, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. FAU - Arbour-Nicitopoulos, Kelly AU - Arbour-Nicitopoulos K AD - Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, Ontario, Canada. FAU - Takken, Tim AU - Takken T AD - Child Development & Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands. FAU - Engelbert, Raoul H H AU - Engelbert RHH AD - Centre of Expertise Urban Vitality, Faculty of Health, Amsterdam University of Applied Sciences, Amsterdam, The Netherlands. AD - Department of Rehabilitation Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands. FAU - Bloemen, Manon A T AU - Bloemen MAT AD - Research Centre Healthy and Sustainable Living, Research group Lifestyle and Health, Utrecht University of Applied Sciences, Utrecht, The Netherlands. LA - eng PT - Journal Article PT - Review DEP - 20241106 PL - United States TA - Arch Rehabil Res Clin Transl JT - Archives of rehabilitation research and clinical translation JID - 101763542 PMC - PMC11734052 OTO - NOTNLM OT - Accelerometry OT - Gait abnormality OT - Meta-analysis OT - Physical activity OT - Psychometric properties OT - Rehabilitation OT - Systematic review COIS- Supported by Foundation Innovation Alliance--Regional Attention and Action for Knowledge Circulation (SIA Raak. MKB12.002). EDAT- 2025/01/17 18:22 MHDA- 2025/01/17 18:23 PMCR- 2024/11/06 CRDT- 2025/01/17 14:50 PHST- 2025/01/17 18:23 [medline] PHST- 2025/01/17 18:22 [pubmed] PHST- 2025/01/17 14:50 [entrez] PHST- 2024/11/06 00:00 [pmc-release] AID - S2590-1095(24)00097-1 [pii] AID - 100384 [pii] AID - 10.1016/j.arrct.2024.100384 [doi] PST - epublish SO - Arch Rehabil Res Clin Transl. 2024 Nov 6;6(4):100384. doi: 10.1016/j.arrct.2024.100384. eCollection 2024 Dec. PMID- 39820456 OWN - NLM STAT- MEDLINE DCOM- 20250501 LR - 20250620 IS - 1460-2245 (Electronic) IS - 0957-4824 (Linking) VI - 40 IP - 1 DP - 2025 Jan 17 TI - Nutrition literacy in Vietnamese pregnant women: a cross-sectional study. LID - daae187 [pii] LID - 10.1093/heapro/daae187 [doi] AB - Inadequate nutrition intake during pregnancy elevates the risk of adverse health outcomes during pregnancy, with potential long-term repercussions for both mother and child, extending to subsequent generations. Current initiatives to improve individual dietary habits emphasize promoting nutrition literacy (NL), which encompasses the ability to access, comprehend, and use basic nutrition information and services necessary for making appropriate nutrition decisions. However, there were limited data on the NL of pregnant women in Vietnam. Therefore, this study aims to explore the NL levels of Vietnamese pregnant women and examine the factors related to their NL. A total of 360 Vietnamese pregnant women participated in the study from May to September 2023. A validated questionnaire (Nutrition Literacy Assessment Instrument for Pregnant Women, NLAI-P), assessing the knowledge, behavior and skill, was applied. A general linear model with univariate linear regression analysis was conducted to identify predictor factors of NL. The findings revealed that 70.3% of participants had inadequate NL. Among the three dimensions, nutrition knowledge was particularly low, with no respondents achieving an adequate level and 94.7% scoring at an inadequate level. High household monthly income, age, normal prepregnancy weight and indoor work were statistically associated with higher NL scores. This study highlights the limited NL among Vietnamese pregnant women. Increasing NL is crucial for supporting their optimal healthy diet, enhancing the health of pregnant women and their offspring and future generations. CI - (c) The Author(s) 2025. Published by Oxford University Press. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Nguyen, Hoan Thi AU - Nguyen HT AD - Department of Health Care Science, China Medical University, 100, Sec. 1, Jingmao Road, Taichung 406040, Taiwan. AD - Faculty of Nursing and Medical Technology, University of Medicine and Pharmacy at Ho Chi Minh City, 201 Nguyen Chi Thanh, District 5, Ho Chi Minh City, Vietnam. FAU - Tran, Hang Thi Thuy AU - Tran HTT AD - University of Medicine and Pharmacy at Ho Chi Minh City Hospital, 216 Hong Bang, District 5, Ho Chi Minh City 17000, Vietnam. FAU - Dao-Tran, Tiet-Hanh AU - Dao-Tran TH AD - Center of Health Services Research, Faculty of Medicine, University of Queensland, Level 5, UQ Health Science Building, Herston Campus, Brisban, QLD4006,Australia. FAU - Huang, Li-Chi AU - Huang LC AUID- ORCID: 0000-0003-1152-6596 AD - Department of Health Care Science, China Medical University, 100, Sec. 1, Jingmao Road, Taichung 406040, Taiwan. AD - School of Nursing, China Medical University, 100, Jingmao Road, Beitun District, Taichung 406040, Taiwan. AD - Department of Nursing, China Medical University Children Hospital, 100, Sec. 1, Jingmao Road, Taichung 406040, Taiwan. LA - eng GR - DMR-111-1168/China Medical University Hospital/ PT - Journal Article PL - England TA - Health Promot Int JT - Health promotion international JID - 9008939 SB - IM EIN - Health Promot Int. 2025 May 13;40(3):daaf087. doi: 10.1093/heapro/daaf087. PMID: 40521756 MH - Humans MH - Female MH - Vietnam MH - Cross-Sectional Studies MH - Pregnancy MH - *Health Literacy/statistics & numerical data MH - Adult MH - *Health Knowledge, Attitudes, Practice MH - *Pregnant People/psychology MH - Surveys and Questionnaires MH - Young Adult MH - Nutritional Status MH - Socioeconomic Factors MH - Southeast Asian People OTO - NOTNLM OT - Vietnam OT - maternal and child health OT - nutrition literacy OT - pregnant nutrition promotion OT - pregnant women EDAT- 2025/01/17 18:22 MHDA- 2025/01/17 18:23 CRDT- 2025/01/17 13:16 PHST- 2025/01/17 18:23 [medline] PHST- 2025/01/17 18:22 [pubmed] PHST- 2025/01/17 13:16 [entrez] AID - 7959148 [pii] AID - 10.1093/heapro/daae187 [doi] PST - ppublish SO - Health Promot Int. 2025 Jan 17;40(1):daae187. doi: 10.1093/heapro/daae187. PMID- 39819913 OWN - NLM STAT- MEDLINE DCOM- 20250501 LR - 20250606 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 1 DP - 2025 Jan 15 TI - Investigating male factors and their relationships with reproductive health outcomes: a case-control study protocol for Towards Optimal Fertility, Fathering, and Fatherhood studY (TOFFFY) in Singapore. PG - e088143 LID - 10.1136/bmjopen-2024-088143 [doi] LID - e088143 AB - INTRODUCTION: Despite the global prevalence of low fertility rates, male contributions to fertility and reproductive health outcomes have been understudied. This study aims to investigate the male contribution to fertility and explore the underlying biological mechanisms. Specifically, we aim to (1) identify male factors associated with successful pregnancy, (2) develop a fertility index incorporating modifiable factors for both males and females to predict pregnancy rate and (3) explore the relationship of male modifiable factors with semen parameters and molecular characteristics. METHODS AND ANALYSIS: We will conduct an unmatched case-control study involving 240 couples with impaired male fertility (cases) and 240 couples with normal male fertility (controls). Between July 2024 and June 2026, we will recruit 480 eligible couples from KK Women's and Children's Hospital, Singapore. Male and female participants will complete questionnaires on sociodemographics, general health and lifestyle factors, and their anthropometry and body fat composition will be measured. Blood and semen samples from the male participants will be collected for biochemical, molecular and semen analyses. Predictive male factors will be identified using the least absolute shrinkage and selection operator method, accounting for female factors. We will construct a logistic regression model incorporating both male and female factors to derive a fertility index, which will be evaluated using cross-validation on subsets of the study population. Multivariable linear regression will be used to explore relationships between male modifiable exposures and semen parameters. ETHICS AND DISSEMINATION: The study protocol has received approval from the Centralised Institutional Review Board of SingHealth (2024/2120), Singapore. Participants will provide written informed consent. Study results will be disseminated through conferences and peer-reviewed scientific journals. TRIAL REGISTRATION NUMBER: NCT06293235. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY. Published by BMJ Group. FAU - Ku, Chee Wai AU - Ku CW AUID- ORCID: 0000-0003-3719-3005 AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore. AD - Duke-NUS Medical School, Singapore. FAU - Pek, Jun Wei AU - Pek JW AD - Temasek Life Sciences Laboratory, Singapore. AD - Department of Biological Sciences, National University of Singapore, Singapore. FAU - Cheung, Yin Bun AU - Cheung YB AD - Program in Health Services and Systems Research and Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore. AD - Tampere Centre for Child, Adolescent and Maternal Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland. FAU - Tharmalingam Durgahshree, Melissa D/O AU - Tharmalingam Durgahshree MD AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore. FAU - Chan, Melinda AU - Chan M AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore. FAU - Lee, Yie Hou AU - Lee YH AD - Duke-NUS Medical School, Singapore. AD - Singapore-MIT Alliance for Research and Technology, Singapore. FAU - Godfrey, Keith AU - Godfrey K AD - MRC Lifecourse Epidemiology Unit, University of Southampton and Southampton University Hospitals NHS Trust, Southampton, UK. AD - University of Southampton and University Hospital Southampton National Health Service Foundation Trust, National Institute for Health Research Southampton Biomedical Research Centre, Southampton, UK. FAU - Yap, Fabian AU - Yap F AD - Duke-NUS Medical School, Singapore. AD - Department of Paediatrics, KK Women's and Children's Hospital, Singapore. AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. FAU - Chan, Jerry Kok Yen AU - Chan JKY AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore. AD - Duke-NUS Medical School, Singapore. FAU - Loy, See Ling AU - Loy SL AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore loyseeling@duke-nus.edu.sg. AD - Duke-NUS Medical School, Singapore. LA - eng SI - ClinicalTrials.gov/NCT06293235 PT - Journal Article PT - Observational Study DEP - 20250115 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Adult MH - Female MH - Humans MH - Male MH - Pregnancy MH - Case-Control Studies MH - *Fertility/physiology MH - *Infertility, Male/epidemiology MH - Pregnancy Rate MH - *Reproductive Health MH - Research Design MH - Semen Analysis MH - Singapore PMC - PMC11751997 OTO - NOTNLM OT - Male infertility OT - Pregnancy OT - Subfertility COIS- Competing interests: KG received reimbursement for speaking at conferences sponsored by companies that sell nutritional products and is part of an academic consortium that received research funding from Abbott Nutrition, Nestle and Danone. All other authors declare no competing interests. EDAT- 2025/01/17 18:23 MHDA- 2025/01/17 18:24 PMCR- 2025/01/15 CRDT- 2025/01/17 12:50 PHST- 2025/01/17 18:24 [medline] PHST- 2025/01/17 18:23 [pubmed] PHST- 2025/01/17 12:50 [entrez] PHST- 2025/01/15 00:00 [pmc-release] AID - bmjopen-2024-088143 [pii] AID - 10.1136/bmjopen-2024-088143 [doi] PST - epublish SO - BMJ Open. 2025 Jan 15;15(1):e088143. doi: 10.1136/bmjopen-2024-088143. PMID- 39819161 OWN - NLM STAT- MEDLINE DCOM- 20250501 LR - 20260811 IS - 1545-1569 (Electronic) IS - 1055-6656 (Linking) VI - 62 IP - 2 DP - 2025 Feb TI - Lives of Irish Adolescents Who Were Born With a Cleft (LIA-Cleft). PG - 188-200 LID - 10.1177/10556656241311045 [doi] AB - ObjectiveThe objective was to describe the lives of adolescents, who were born with cleft lip and palate (CL/P), in comparison to the general population as recorded in Growing up in Ireland (GUI), the national longitudinal study of children and youth.DesignThis was a cross-sectional study.Setting: The study was performed in a cleft center at a university teaching hospital.Participants: Adolescents born with CL/P in the years 2007 to 2009.Interventions: Growing up in Ireland questionnaires, which assessed demographics, health and experience of friendship, school, leisure, and social life, were adapted and administered to adolescents and their parents/guardians, who were identified from a prospectively maintained cleft database. Data were compared to that of GUI Cohort '08.Main Outcome Measures: Outcome measures comprised primary caregiver and young person self-report items. Mental health and psychological well-being were assessed using validated instruments including the Strengths and Difficulties Questionnaire.ResultsThirty adolescents (10 female, 20 male) participated in the LIA-Cleft group. LIA-Cleft respondents indicated poorer ratings of both medical and dental health than the GUI group. Responses to questions regarding friendship, bullying, physical activity, social media, and screen time were similar in the GUI and LIA-Cleft groups. The LIA-Cleft group were less satisfied with their lives and exhibited lower self-esteem than the GUI group, but did not differ in measures of mental health and well-being or socioemotional well-being.ConclusionsIn spite of reporting poorer medical and dental health, young people who were born with CL/P in Ireland lead lives that are broadly similar to their peers in the general population. FAU - Blacam, Catherine de AU - Blacam C AUID- ORCID: 0000-0002-3197-4161 AD - Department of Plastic Surgery, Children's Health Ireland, Dublin, Ireland. AD - Department of Paediatrics, Trinity College Dublin, Dublin, Ireland. AD - Royal College of Surgeons in Ireland, Dublin, Ireland. FAU - Geoghegan, Bridget AU - Geoghegan B AD - Public and Patient Involvement (PPI) Contributor, Dublin, Ireland. FAU - Nixon, Elizabeth AU - Nixon E AD - School of Psychology, Trinity College Dublin, Dublin, Ireland. FAU - Nolan, Anne AU - Nolan A AD - Department of Social Research, Economic and Social Research Institute, Dublin, Ireland. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250117 PL - United States TA - Cleft Palate Craniofac J JT - The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association JID - 9102566 SB - IM MH - Humans MH - Female MH - Adolescent MH - Ireland/epidemiology MH - Male MH - Cross-Sectional Studies MH - *Cleft Palate/psychology MH - *Cleft Lip/psychology MH - Surveys and Questionnaires MH - Longitudinal Studies OTO - NOTNLM OT - cleft lip and palate OT - outcomes OT - psychological assessment OT - quality of life OT - team care COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/01/17 18:22 MHDA- 2025/03/17 18:30 CRDT- 2025/01/17 12:15 PHST- 2025/03/17 18:30 [medline] PHST- 2025/01/17 18:22 [pubmed] PHST- 2025/01/17 12:15 [entrez] AID - 10.1177/10556656241311045 [doi] PST - ppublish SO - Cleft Palate Craniofac J. 2025 Feb;62(2):188-200. doi: 10.1177/10556656241311045. Epub 2025 Jan 17. PMID- 39817816 OWN - NLM STAT- MEDLINE DCOM- 20250501 LR - 20260929 IS - 1538-7755 (Electronic) IS - 1055-9965 (Print) IS - 1055-9965 (Linking) VI - 34 IP - 4 DP - 2025 Apr 3 TI - Body Composition at Diagnosis and Early Response in Pediatric Hodgkin Lymphoma. PG - 560-567 LID - 10.1158/1055-9965.EPI-24-1231 [doi] AB - BACKGROUND: The association between skeletal, muscle, and adipose tissue (body composition) and early response using PET in pediatric Hodgkin lymphoma remains unstudied. METHODS: Patients enrolled on Children's Oncology Group studies AHOD0031 (intermediate-risk Hodgkin lymphoma) and AHOD0831 (high-risk Hodgkin lymphoma) with digital abdominal CT scans at diagnosis and PET scans after 2 cycles (PET2) were included. Two consecutive slices at the third lumbar vertebra were identified, and skeletal muscle index (SMI; in cm2/m2) and total adipose tissue index (TATI; in cm2/m2) were calculated using sliceOmatic and height at diagnosis. SMI and TATI were divided into quintiles [Q1 (lowest) to Q5 (highest)]. Body mass index (BMI) was calculated using height and weight at diagnosis. The association between baseline body composition (SMI, TATI, and BMI) and positive PET2 was examined using logistic regression, adjusting for age at diagnosis, sex, race/ethnicity, stage, histology, bulk disease, and "B" symptoms. RESULTS: Among 1,033 included patients, PET2 was positive in 314 (30.4%) patients. SMI was not associated with positive PET2. Extremes of TATI were associated with positive PET2, when compared with the middle TATI quintile [reference: Q3; ORQ1 = 1.63; 95% confidence interval (CI) = 1.03-2.60; P = 0.04; ORQ2 = 1.82; 95% CI = 1.17-2.82; P = 0.008; ORQ5 = 1.94; 95% CI = 1.23-3.05; P = 0.005]. The association between BMI in obesity range and positive PET2 trended toward significance (OR = 1.42; 95% CI = 0.98-2.04; P = 0.06; ref = normal weight). CONCLUSIONS: Extremes of adipose tissue at diagnosis influence early response among pediatric Hodgkin lymphoma. IMPACT: Validation of results from this study could inform studies investigating body composition-based chemotherapy dosing. CI - (c)2025 American Association for Cancer Research. FAU - Wadhwa, Aman AU - Wadhwa A AUID- ORCID: 0000-0002-3245-2218 AD - Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, Alabama. AD - Division of Pediatric Hematology/Oncology, University of Alabama at Birmingham, Birmingham, Alabama. FAU - Dai, Chen AU - Dai C AUID- ORCID: 0000-0002-2695-1010 AD - Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, Alabama. FAU - Kessel, Sandra AU - Kessel S AUID- ORCID: 0009-0003-9811-0768 AD - Quality Assurance Review Center, Providence, Rhode Island. FAU - Richman, Joshua S AU - Richman JS AUID- ORCID: 0000-0002-6166-7488 AD - Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, Alabama. FAU - Shen, Wei AU - Shen W AUID- ORCID: 0000-0003-4838-4923 AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Columbia University Irving Medical Center, New York, New York. AD - Institute of Human Nutrition, Columbia University Irving Medical Center, New York, New York. AD - Columbia Magnetic Resonance Research Center (CMRRC), Columbia University, New York, New York. FAU - Kahn, Justine M AU - Kahn JM AUID- ORCID: 0000-0003-3330-6754 AD - Division of Pediatric Hematology/Oncology, Columbia University, New York, New York. FAU - Castellino, Sharon M AU - Castellino SM AUID- ORCID: 0000-0001-8367-2002 AD - Division of Pediatric Hematology/Oncology, Emory University, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia. FAU - Kelly, Kara M AU - Kelly KM AUID- ORCID: 0000-0003-1473-3937 AD - Department of Pediatric Oncology, Roswell Park Comprehensive Cancer Center, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York. FAU - Friedman, Debra L AU - Friedman DL AUID- ORCID: 0000-0002-0589-4176 AD - Vanderbilt University School of Medicine and Vanderbilt-Ingram Cancer Center, Nashville, Tennessee. FAU - Bhatia, Smita AU - Bhatia S AUID- ORCID: 0000-0002-7755-5683 AD - Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, Alabama. AD - Division of Pediatric Hematology/Oncology, University of Alabama at Birmingham, Birmingham, Alabama. LA - eng GR - R25 CA203650/CA/NCI NIH HHS/United States GR - Leukemia and Lymphoma Society (LLS)/ GR - P30 DK26687/National Institutes of Health (NIH)/ GR - U10CA180886/National Cancer Institute (NCI)/ GR - UG1 CA189955/CA/NCI NIH HHS/United States GR - P30 DK026687/DK/NIDDK NIH HHS/United States GR - St. Baldrick's Foundation (SBF)/ GR - U24 CA180803/CA/NCI NIH HHS/United States GR - U10 CA180899/CA/NCI NIH HHS/United States GR - American Cancer Society (ACS)/ GR - National Cancer Institute (NCI)/ GR - U10 CA180886/CA/NCI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PL - United States TA - Cancer Epidemiol Biomarkers Prev JT - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JID - 9200608 SB - IM MH - Humans MH - *Hodgkin Disease/drug therapy/diagnosis/diagnostic imaging/pathology MH - Male MH - Female MH - Child MH - *Body Composition MH - Adolescent MH - Child, Preschool MH - Body Mass Index MH - *Antineoplastic Combined Chemotherapy Protocols/therapeutic use PMC - PMC11968239 MID - NIHMS2051087 COIS- Conflicts of Interest: The authors declare no potential conflicts of interest. EDAT- 2025/01/16 16:59 MHDA- 2025/04/03 18:25 PMCR- 2025/10/03 CRDT- 2025/01/16 09:53 PHST- 2024/08/19 00:00 [received] PHST- 2024/11/11 00:00 [revised] PHST- 2025/01/14 00:00 [accepted] PHST- 2025/04/03 18:25 [medline] PHST- 2025/01/16 16:59 [pubmed] PHST- 2025/01/16 09:53 [entrez] PHST- 2025/10/03 00:00 [pmc-release] AID - 751131 [pii] AID - 10.1158/1055-9965.EPI-24-1231 [doi] PST - ppublish SO - Cancer Epidemiol Biomarkers Prev. 2025 Apr 3;34(4):560-567. doi: 10.1158/1055-9965.EPI-24-1231. PMID- 39815251 OWN - NLM STAT- MEDLINE DCOM- 20250116 LR - 20250522 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Jan 15 TI - Urban and rural residence: their influence on food group consumption in Iran. PG - 169 LID - 10.1186/s12889-024-21211-3 [doi] LID - 169 AB - BACKGROUND: Urbanization is expanding in Iran, leading to the emergence of three distinct socio-geographical areas: urban, rural, and suburban areas. These different areas may exhibit significant variations in dietary patterns. This study investigates the association between people's place of residence and their consumption of different food groups. METHODS: This study utilized data from Iran's Food and Nutrition Surveillance System (FNS). A total of 1697 participants were randomly recruited from different rural (N = 568), urban (N = 568), and suburban (N = 561) regions across Iran. Their food intake was assessed using a validated dish-based semi-quantitative food frequency questionnaire (DB-FFQ). RESULTS: Rural males consumed significantly more grains (35.51 g/day, p = 0.03) than urban males, while rural females consumed significantly less dairy (-30.07 g/day, p = 0.03) than urban females. Additionally, rural males and females consumed significantly more fats and oils (3.72 g/day, p = 0.01 for males and 5.2 g/day, p < 0.001 for females) than their urban counterparts. Moreover, both suburban females and males were found to consume significantly less fruit compared to urban individuals, with suburban females consuming - 47.41 g/day (p < 0.001) less fruit and suburban males consuming - 60.42 g/day (p = 0.001) less fruit. CONCLUSION: Findings showed that rural men's diets are characterized by higher consumption of grains and fats, while urbanization is linked to increased dairy consumption in women. Additionally, the study highlights a worrying lack of fruit consumption in suburban areas. These findings underscore the necessity of implementing specific nutritional policies to promote dietary diversity in various residential areas. CI - (c) 2024. The Author(s). FAU - Darroudi, Susan AU - Darroudi S AD - Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, 99199-91766, Iran. FAU - Soflaei, Sara Saffar AU - Soflaei SS AD - Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, 99199-91766, Iran. AD - International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, 99199-91766, Iran. FAU - Kamrani, Farzam AU - Kamrani F AD - Department of Nutritional Sciences, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Khorasanchi, Zahra AU - Khorasanchi Z AD - Department of Nutritional Sciences, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Abdollahi, Zahra AU - Abdollahi Z AD - Office of Nutrition Department Society, Health Ministry, Tehran, Iran. FAU - Talkhi, Nasrin AU - Talkhi N AD - Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Allahyari, Maryam AU - Allahyari M AD - Department of Nutritional Sciences, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Sobhani, Seyyed Reza AU - Sobhani SR AD - Department of Nutritional Sciences, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Mohammadi-Bajgiran, Maryam AU - Mohammadi-Bajgiran M AD - International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, 99199-91766, Iran. FAU - Naderkhmseh, Amirmohammad AU - Naderkhmseh A AD - Department of Food Engineering, Faculty of Engineering, Izmir, Turkey. FAU - Aghasizadeh, Maliheh AU - Aghasizadeh M AD - Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, 99199-91766, Iran. AD - International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, 99199-91766, Iran. FAU - Esmaily, Habibollah AU - Esmaily H AD - Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran. EsmailyH@mums.ac.ir. AD - Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. EsmailyH@mums.ac.ir. FAU - Ferns, Gordon AU - Ferns G AD - Brighton and Sussex Medical School, Division of Medical Education, Brighton, UK. FAU - Ghayour-Mobarhan, Majid AU - Ghayour-Mobarhan M AD - Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, 99199-91766, Iran. GhayourM@mums.ac.ir. AD - International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, 99199-91766, Iran. GhayourM@mums.ac.ir. LA - eng PT - Journal Article DEP - 20250115 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Male MH - Iran MH - Female MH - *Rural Population/statistics & numerical data MH - Adult MH - *Urban Population/statistics & numerical data MH - Middle Aged MH - *Diet/statistics & numerical data MH - *Feeding Behavior MH - Young Adult MH - Adolescent MH - Surveys and Questionnaires MH - Nutrition Surveys PMC - PMC11736970 OTO - NOTNLM OT - Dietary pattern OT - Food group OT - Rural OT - Urban OT - Urbanization COIS- Declarations. Ethics approval and consent to participate: This study was conducted according to the guidelines laid down in the Declaration of Helsinki and all procedures involving research study participants were approved by Mashhad University of Medical Sciences ethics committee (IR.MUMS.MEDICAL.REC.1400.489). Written informed consent was obtained from all subjects. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/01/16 00:20 MHDA- 2025/01/16 06:21 PMCR- 2025/01/15 CRDT- 2025/01/15 23:37 PHST- 2024/09/24 00:00 [received] PHST- 2024/12/26 00:00 [accepted] PHST- 2025/01/16 06:21 [medline] PHST- 2025/01/16 00:20 [pubmed] PHST- 2025/01/15 23:37 [entrez] PHST- 2025/01/15 00:00 [pmc-release] AID - 10.1186/s12889-024-21211-3 [pii] AID - 21211 [pii] AID - 10.1186/s12889-024-21211-3 [doi] PST - epublish SO - BMC Public Health. 2025 Jan 15;25(1):169. doi: 10.1186/s12889-024-21211-3. PMID- 39815165 OWN - NLM STAT- MEDLINE DCOM- 20250501 LR - 20250522 IS - 2191-0251 (Electronic) IS - 0334-018X (Linking) VI - 38 IP - 3 DP - 2025 Mar 26 TI - Development of a disease diagnostic model to predict the occurrence of central precocious puberty of female. PG - 254-261 LID - 10.1515/jpem-2024-0419 [doi] AB - OBJECTIVES: To develop a clinical model for predicting the occurrence of Central Precocious Puberty based on the breast development outcomes in chinese girls. METHODS: This is a retrospective study, which included a total of 1,001 girls aged 6-9 years old who visited the outpatient clinic of Beijing Children's Hospital from January 2017 to October 2022 for "breast development". Participants were categorized into pubertal development (PD) cohort and simple premature breast development (PT) according to the criteria, and information was collected and tested for relevant indicators. After dealing with missing data, logistic regression, LASSO regression and random forest were used to screen the variables, and support vector machine models were built with SMOTE oversampling and ten-fold cross-validation to assess the effectiveness of the models in the training and validation sets. RESULTS: A total of 1,001 girls were included in the analysis, of whom 369 (36.9 %) were diagnosed with PD and 632 (63.1 %) with PT. Body mass index (BMI), bone age (BA), luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol (E2), uterine diameter, and ovary volume were identified as the final predictor variables by three variable screening methods. The AUC of the constructed disease diagnostic model was 0.9457 in the developmental cohort and 0.8357 in the external validation group, and sensitivity analyses revealed that the performance of the constructed models with different variable selection strategies was similar. CONCLUSIONS: A disease diagnostic model was developed that may help predict a girl's risk of diagnosing central precocious puberty. CI - (c) 2025 the author(s), published by De Gruyter, Berlin/Boston. FAU - Zhao, Manman AU - Zhao M AD - Department of Endocrinology, Genetics and Metabolism, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. AD - Department of Pediatrics, Beijing Luhe Hospital, Capital Medical University, Beijing, China. FAU - Feng, Guoshuang AU - Feng G AD - Research Center for Big Data and Engineering, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Cao, Bingyan AU - Cao B AD - Department of Endocrinology, Genetics and Metabolism, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Zheng, Yannan AU - Zheng Y AD - Department of Endocrinology, Genetics and Metabolism, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Gong, Chun-Xiu AU - Gong CX AUID- ORCID: 0000-0002-1262-7383 AD - Department of Endocrinology, Genetics and Metabolism, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. AD - Research Center for Big Data and Engineering, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. LA - eng PT - Journal Article DEP - 20250116 PL - Germany TA - J Pediatr Endocrinol Metab JT - Journal of pediatric endocrinology & metabolism : JPEM JID - 9508900 RN - 9002-67-9 (Luteinizing Hormone) RN - 9002-68-0 (Follicle Stimulating Hormone) SB - IM MH - Humans MH - Female MH - *Puberty, Precocious/diagnosis/epidemiology MH - Child MH - Retrospective Studies MH - Prognosis MH - Follow-Up Studies MH - Body Mass Index MH - Luteinizing Hormone/blood MH - *Breast/growth & development MH - China/epidemiology MH - Follicle Stimulating Hormone/blood OTO - NOTNLM OT - central precocious puberty OT - disease diagnostic model OT - female EDAT- 2025/01/16 00:20 MHDA- 2025/03/01 14:40 CRDT- 2025/01/15 23:33 PHST- 2024/08/28 00:00 [received] PHST- 2025/01/03 00:00 [accepted] PHST- 2025/03/01 14:40 [medline] PHST- 2025/01/16 00:20 [pubmed] PHST- 2025/01/15 23:33 [entrez] AID - jpem-2024-0419 [pii] AID - 10.1515/jpem-2024-0419 [doi] PST - epublish SO - J Pediatr Endocrinol Metab. 2025 Jan 16;38(3):254-261. doi: 10.1515/jpem-2024-0419. Print 2025 Mar 26. PMID- 39812306 OWN - NLM STAT- MEDLINE DCOM- 20250415 LR - 20250417 IS - 1537-6613 (Electronic) IS - 0022-1899 (Print) IS - 0022-1899 (Linking) VI - 231 IP - 4 DP - 2025 Apr 15 TI - Association Between Herpes Simplex Virus Type 2 and High-Risk Human Papillomavirus Infections: A Population Study of the National Health and Nutrition Examination Survey, 2009-2016. PG - e650-e658 LID - 10.1093/infdis/jiaf033 [doi] AB - BACKGROUND: Human papillomavirus (HPV) is a leading cause of cervical cancer, with 14 subtypes classified as high-risk HPV (HR-HPV). Despite the availability of vaccines, certain regions still experience limited access. Herpes simplex virus type 2 (HSV-2), a common sexually transmitted infection, is hypothesized to increase the risk of HR-HPV infections. This study aims to individually analyze whether HSV-2 infection increases the risk of each HR-HPV infection in a representative sample of American adults. METHODS: Data were derived from the National Health and Nutrition Examination Survey from 2009 to 2016, involving 4076 female participants. The study utilized logistic regression to estimate the link between HSV-2 infection and HR-HPV infection. We also conducted a stratified analysis to evaluate the impact of HSV-2 on HR-HPV infection in different subgroups. RESULTS: After adjustment, the odds of having HR-HPV infection were 1.46 (95% CI, 1.24-1.71) for those with HSV-2 infection. Moreover, women with HSV-2 infection had higher odds of HPV-18 (odds ratio, 3.01; 95% CI, 2.05-4.41) and HPV-58 (OR, 2.05; 95% CI, 1.52-3.32) infection even after adjusting for potential confounding factors. The results remain significant in subgroup analysis and in the interaction test. CONCLUSIONS: The study found a significant association between HSV-2 infection and HR-HPV infection, particularly with HPV-18 and HPV-58, highlighting the importance of preventing HSV infection and advocating for early vaccination with an HPV vaccine for those vulnerable to HSV infection. Further prospective studies are needed to validate causal associations and elucidate the underlying mechanisms. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of Infectious Diseases Society of America. FAU - Liu, Chuqi AU - Liu C AUID- ORCID: 0009-0004-1354-7758 AD - Department of Obstetrics and Gynecology, Third Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China. FAU - Guo, Yongzhen AU - Guo Y AD - Department of Pathology, Third Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China. AD - Zhengzhou Key Laboratory of Gynecological Disease's Early Diagnosis, Third Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China. FAU - Wang, Lulu AU - Wang L AD - Department of Obstetrics and Gynecology, Third Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China. FAU - Guo, Ruixia AU - Guo R AD - Department of Gynecology, First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China. FAU - Lei, Dongmei AU - Lei D AUID- ORCID: 0000-0002-7260-8141 AD - Department of Pathology, Third Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China. AD - Zhengzhou Key Laboratory of Gynecological Disease's Early Diagnosis, Third Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China. LA - eng GR - SBGJ202302074/Henan Province Science and Technology/ GR - Henan Province Engineering Research Center for Gynecologic Oncology Fertility Protection/ PT - Journal Article PL - United States TA - J Infect Dis JT - The Journal of infectious diseases JID - 0413675 SB - IM MH - Humans MH - Female MH - *Papillomavirus Infections/epidemiology/virology/complications MH - Adult MH - *Herpesvirus 2, Human MH - Nutrition Surveys MH - Middle Aged MH - United States/epidemiology MH - Young Adult MH - *Herpes Genitalis/epidemiology/virology/complications MH - Risk Factors MH - Aged MH - Papillomaviridae MH - Adolescent MH - Logistic Models MH - Cross-Sectional Studies PMC - PMC11998555 OTO - NOTNLM OT - National Health and Nutrition Examination Survey OT - cervical cancer OT - herpes simplex virus type 2 OT - high-risk human papillomavirus OT - sexually transmitted diseases COIS- Potential conflicts of interest. All authors: No reported conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. EDAT- 2025/01/15 12:23 MHDA- 2025/04/15 18:24 PMCR- 2025/01/15 CRDT- 2025/01/15 07:13 PHST- 2024/07/11 00:00 [received] PHST- 2025/01/11 00:00 [accepted] PHST- 2025/04/15 18:24 [medline] PHST- 2025/01/15 12:23 [pubmed] PHST- 2025/01/15 07:13 [entrez] PHST- 2025/01/15 00:00 [pmc-release] AID - 7954310 [pii] AID - jiaf033 [pii] AID - 10.1093/infdis/jiaf033 [doi] PST - ppublish SO - J Infect Dis. 2025 Apr 15;231(4):e650-e658. doi: 10.1093/infdis/jiaf033. PMID- 39810469 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250129 IS - 2561-6722 (Electronic) IS - 2561-6722 (Linking) VI - 8 DP - 2025 Jan 14 TI - Supervised and Unsupervised Screen Time and Its Association With Physical, Mental, and Social Health of School-Going Children in Dhaka, Bangladesh: Cross-Sectional Study. PG - e62943 LID - 10.2196/62943 [doi] LID - e62943 AB - BACKGROUND: Children's screen time has substantially increased worldwide, including in Bangladesh, especially since the pandemic, which is raising concern about its potential adverse effects on their physical, mental, and social health. Parental supervision may play a crucial role in mitigating these negative impacts. However, there is a lack of empirical evidence assessing the relationship between parental screen time supervision and health outcomes among school children in Dhaka, Bangladesh. OBJECTIVE: We aimed to explore the association between supervised and unsupervised screen time on the physical, mental, and social health of school-going children in Dhaka, Bangladesh. METHODS: We conducted a cross-sectional descriptive study between July 2022 and June 2024. A total of 420 children, aged 6-14 years, were enrolled via the stratified random sampling method across three English medium and three Bangla medium schools in Dhaka. Data were collected through a semistructured questionnaire; anthropometry measurements; and the Bangla-validated Strength and Difficulties Questionnaire (SDQ), Pittsburgh Sleep Quality Index (PSQI) Scale, and Spencer Children Anxiety Scale (SCAS). RESULTS: A total of 234 out of 420 students (56%) used digital screen devices without parental supervision. We did not find a substantial difference in the duration of the daily mean use of digital devices among the supervised students (4.5 hours, SD 2.2 hours) and the unsupervised students (4.6 hours, SD 2.4 hours). According to the type of school, English medium school children had a mean higher screen time (5.46 hours, SD 2.32 hours) compared to Bangla medium school children (3.67 hours, SD 2.00 hours). Headache was significantly higher among the unsupervised digital screen users compared to those who used digital screens with parental supervision (175/336 students, 52.1% versus 161/336 students, 47.9%; P<.003). Moreover, students who used digital screens without parental supervision had poor quality of sleep. Behavioral problems such as conduct issues (119/420 students, 28.3%) and peer difficulties (121/420 students, 28.8%) were observed among the participants. However, when comparing supervised and unsupervised students, we found no statistically significant differences in the prevalence of these issues. CONCLUSIONS: The findings of the study showed that the lack of screen time supervision is associated with negative health effects in children. The roles of various stakeholders, including schools, parents, policy makers, and students themselves, are crucial in developing effective guidelines for managing screen use among students. Further research is needed to demonstrate causal mechanisms; identify the best interventions; and determine the role of mediators and moderators in households, surroundings, and schools. CI - (c) Shahria Hafiz Kakon, Tanjir Rashid Soron, Mohammad Sharif Hossain, Rashidul Haque, Fahmida Tofail. Originally published in JMIR Pediatrics and Parenting (https://pediatrics.jmir.org). FAU - Kakon, Shahria Hafiz AU - Kakon SH AUID- ORCID: 0000-0002-1127-4993 AD - Infectious Diseases Division, International Centre for Diarrheal Disease Research, Bangladesh, 68, Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh, 880 1726428760. FAU - Soron, Tanjir Rashid AU - Soron TR AUID- ORCID: 0000-0001-9810-5000 AD - Telepsychiatry Research and Innovation Network Ltd, Dhaka, Bangladesh. FAU - Hossain, Mohammad Sharif AU - Hossain MS AUID- ORCID: 0000-0002-9876-7722 AD - Infectious Diseases Division, International Centre for Diarrheal Disease Research, Bangladesh, 68, Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh, 880 1726428760. FAU - Haque, Rashidul AU - Haque R AUID- ORCID: 0000-0001-5100-136X AD - Infectious Diseases Division, International Centre for Diarrheal Disease Research, Bangladesh, 68, Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh, 880 1726428760. FAU - Tofail, Fahmida AU - Tofail F AUID- ORCID: 0000-0003-2301-9196 AD - Maternal and Child Nutrition, Nutrition Research Division, International Centre for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh. LA - eng PT - Journal Article DEP - 20250114 PL - Canada TA - JMIR Pediatr Parent JT - JMIR pediatrics and parenting JID - 101727244 PMC - PMC11749080 OTO - NOTNLM OT - Pittsburgh Sleep Quality Scale OT - Spencer Children Anxiety Scale OT - Strength and Difficulties Questionnaire OT - behavioral problems OT - children OT - headache OT - parental supervision OT - screen time OT - sleep quality COIS- Conflicts of Interest: None declared. EDAT- 2025/01/15 06:21 MHDA- 2025/01/15 06:22 PMCR- 2025/01/14 CRDT- 2025/01/15 02:03 PHST- 2024/06/05 00:00 [received] PHST- 2024/10/05 00:00 [revised] PHST- 2024/10/10 00:00 [accepted] PHST- 2025/01/15 06:22 [medline] PHST- 2025/01/15 06:21 [pubmed] PHST- 2025/01/15 02:03 [entrez] PHST- 2025/01/14 00:00 [pmc-release] AID - v8i1e62943 [pii] AID - 62943 [pii] AID - 10.2196/62943 [doi] PST - epublish SO - JMIR Pediatr Parent. 2025 Jan 14;8:e62943. doi: 10.2196/62943. PMID- 39810453 OWN - NLM STAT- MEDLINE DCOM- 20250115 LR - 20260705 IS - 2291-5222 (Electronic) IS - 2291-5222 (Linking) VI - 13 DP - 2025 Jan 14 TI - A Mobile App-Based Gratitude Intervention's Effect on Mental Well-Being in University Students: Randomized Controlled Trial. PG - e53850 LID - 10.2196/53850 [doi] LID - e53850 AB - BACKGROUND: Gratitude interventions are used to cultivate a sense of gratitude for life and others. There have been mixed results of the efficacy of gratitude interventions' effect on psychological well-being with a variety of populations and methodologies. OBJECTIVES: The objective of our study was to test the effectiveness of a gratitude intervention smartphone app on university students' psychological well-being. METHODS: We used a randomized experimental design to test our objective. Participants were recruited undergraduate students from a web-based university study recruitment system. Participants completed 90 web-based survey questions on their emotional well-being and personality traits at the beginning and end of the 3-week research period. Their depression, anxiety, and stress levels were measured with the Depression, Anxiety, and Stress Scale (DASS-21). After the baseline survey, participants were randomly assigned to either the control or the intervention. Participants in the intervention group used both a fully automated mobile sensing app and a gratitude intervention mobile iOS smartphone app designed for youth users and based on previous gratitude interventions and exercises. The gratitude intervention app prompted users to complete daily gratitude exercises on the app including a gratitude journal, a gratitude photo book, an imagine exercise, a speech exercise, and meditation. Participants in the control group used only the mobile sensing app, which passively collected smartphone sensory data on mobility, screen time, sleep, and social interactions. RESULTS: A total of 120 participants met the inclusion criteria, and 27 were lost to follow-up for a total of 41 participants in the intervention group and 52 in the control group providing complete data. Based on clinical cutoffs from the baseline assessment, 56 out of 120 participants were identified as being in a subsample with at least moderate baseline symptomatology. Participants in the subsample with at least moderate baseline symptomatology reported significantly lower symptoms of depression, anxiety, and stress postintervention (Cohen d=-0.68; P=.04) but not in the full sample with low baseline symptomatology (Cohen d=0.16; P=.46). The number of times the app was accessed was not correlated with changes in either the subsample (r=0.01; P=.98) or the full sample (r=-0.04; P=.79). CONCLUSIONS: University students experiencing moderate to severe distress can benefit from a gratitude intervention smartphone app to improve symptoms of depression, anxiety, and stress. The number of times the gratitude intervention app was used is not related to well-being outcomes. Clinicians could look at incorporating gratitude apps with other mental health treatments or for those waitlisted as a cost-effective and minimally guided option for university students experiencing psychological distress. CI - (c) Chloe Fuller, Silvia Marin-Dragu, Ravishankar Subramani Iyer, Sandra Melanie Meier. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org). FAU - Fuller, Chloe AU - Fuller C AUID- ORCID: 0009-0006-6955-365X AD - Department of Psychology, Saint Mary's University, Halifax, NS, Canada. FAU - Marin-Dragu, Silvia AU - Marin-Dragu S AUID- ORCID: 0000-0002-1889-0377 AD - IWK Health Centre Department of Psychiatry & Specific Care Clinics, Department of Psychiatry, Dalhousie University, 5850/5980 University Ave, Halifax, NS, B3K 6R8, Canada, 1 902-470-7720. AD - Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS, Canada. FAU - Iyer, Ravishankar Subramani AU - Iyer RS AUID- ORCID: 0000-0001-8381-8307 AD - Department of Computer Science, Dalhousie University, Halifax, NS, Canada. FAU - Meier, Sandra Melanie AU - Meier SM AUID- ORCID: 0000-0002-3287-5894 AD - IWK Health Centre Department of Psychiatry & Specific Care Clinics, Department of Psychiatry, Dalhousie University, 5850/5980 University Ave, Halifax, NS, B3K 6R8, Canada, 1 902-470-7720. AD - Department of Computer Science, Dalhousie University, Halifax, NS, Canada. LA - eng SI - ClinicalTrials.gov/NCT06621745 PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20250114 PL - Canada TA - JMIR Mhealth Uhealth JT - JMIR mHealth and uHealth JID - 101624439 SB - IM MH - Humans MH - Female MH - *Mobile Applications/standards/statistics & numerical data MH - Male MH - *Students/psychology/statistics & numerical data MH - Universities/organization & administration/statistics & numerical data MH - Surveys and Questionnaires MH - Young Adult MH - Adult MH - Psychometrics/instrumentation/methods MH - Anxiety/psychology/therapy MH - Adolescent MH - *Mental Health/statistics & numerical data MH - Stress, Psychological/psychology/therapy MH - Depression/psychology/therapy PMC - PMC11749078 OTO - NOTNLM OT - gratitude exercises OT - gratitude intervention OT - mobile phone OT - psychological well-being OT - smartphone app COIS- Conflicts of Interest: None declared. EDAT- 2025/01/15 06:21 MHDA- 2025/01/15 06:22 PMCR- 2025/01/14 CRDT- 2025/01/15 01:53 PHST- 2023/10/23 00:00 [received] PHST- 2024/10/02 00:00 [revised] PHST- 2024/11/19 00:00 [accepted] PHST- 2025/01/15 06:22 [medline] PHST- 2025/01/15 06:21 [pubmed] PHST- 2025/01/15 01:53 [entrez] PHST- 2025/01/14 00:00 [pmc-release] AID - v13i1e53850 [pii] AID - 53850 [pii] AID - 10.2196/53850 [doi] PST - epublish SO - JMIR Mhealth Uhealth. 2025 Jan 14;13:e53850. doi: 10.2196/53850. PMID- 39810329 OWN - NLM STAT- MEDLINE DCOM- 20250515 LR - 20260905 IS - 1530-0315 (Electronic) IS - 0195-9131 (Linking) VI - 57 IP - 6 DP - 2025 Jun 1 TI - Validity of A-Mode Ultrasound for Estimating Body Fat Percentage of Young Adult Athletes: A Multicomponent Model Study. PG - 1239-1245 LID - 10.1249/MSS.0000000000003651 [doi] AB - PURPOSE: This study compared %BF US with %BF 4C in young adult athletes. METHODS: University club sport athletes (86 women, 138 men) from a variety of teams participated. ADP, DXA, and bioimpedance spectroscopy were used to measure body volume, bone mineral content, and total body water, respectively, for the 4C model. Ultrasound measurements were taken at three sites to estimate %BF US . Comparisons between %BF US and %BF 4C were evaluated with Pearson correlation, paired t -test, linear regression, equivalence testing, and plots of individual errors. RESULTS: For the combined sample of men and women ( N = 224), the two methods were highly correlated ( r = 0.93) with a constant error (CE) of 0.8% BF ( P < 0.001) and standard error of estimate (SEE) of 3.0% BF. The 90% confidence intervals of the mean difference (0.47 to 1.17) were well within the +/-2% BF limits for equivalence testing, and no bias was evident from the error plot. However, equivalence testing failed to remain inside the +/-2% BF range for women, and the prediction errors for women (CE = 1.9% BF, P < 0.001, SEE = 3.2% BF) were larger than for men (CE = 0.1% BF, P = 0.597, SEE = 2.8% BF). CONCLUSIONS: Overall, the %BF US errors were low, suggesting that A-mode ultrasound is a valid field measure of %BF for young adult athletes. Accuracy is better for men than women. CI - Copyright (c) 2025 by the American College of Sports Medicine. FAU - Wagner, Dale R AU - Wagner DR AUID- ORCID: 0000-0003-1575-1555 AD - Kinesiology and Health Science, Utah State University, Logan, UT. FAU - Cafferty, Elizabeth A AU - Cafferty EA AD - Kinesiology and Health Science, Utah State University, Logan, UT. FAU - Harper, Sara A AU - Harper SA FAU - Vakula, Michael N AU - Vakula MN AD - Kinesiology and Health Science, Utah State University, Logan, UT. LA - eng PT - Journal Article PT - Validation Study DEP - 20250115 PL - United States TA - Med Sci Sports Exerc JT - Medicine and science in sports and exercise JID - 8005433 SB - IM MH - Humans MH - Male MH - Female MH - Ultrasonography/methods MH - Young Adult MH - *Adipose Tissue/diagnostic imaging MH - Absorptiometry, Photon MH - Adult MH - *Athletes MH - Adolescent MH - *Body Composition MH - Bone Density MH - Electric Impedance MH - Reproducibility of Results OTO - NOTNLM OT - BODY COMPOSITION OT - MULTICOMPARTMENT OT - SPORTS OT - SUBCUTANEOUS ADIPOSE TISSUE EDAT- 2025/01/15 06:21 MHDA- 2025/05/15 06:34 CRDT- 2025/01/15 00:43 PHST- 2025/05/15 06:34 [medline] PHST- 2025/01/15 06:21 [pubmed] PHST- 2025/01/15 00:43 [entrez] AID - 00005768-990000000-00705 [pii] AID - 10.1249/MSS.0000000000003651 [doi] PST - ppublish SO - Med Sci Sports Exerc. 2025 Jun 1;57(6):1239-1245. doi: 10.1249/MSS.0000000000003651. Epub 2025 Jan 15. PMID- 39806550 OWN - NLM STAT- MEDLINE DCOM- 20250501 LR - 20250721 IS - 1365-2214 (Electronic) IS - 0305-1862 (Print) IS - 0305-1862 (Linking) VI - 51 IP - 1 DP - 2025 Jan TI - The Performance of Ankle- and Waist-Based Accelerometry in Quantifying Physical Activity Intensity Among 6- to 24-Month-Year-Olds: A Semistructured Laboratory Study. PG - e70035 LID - 10.1111/cch.70035 [doi] LID - e70035 AB - OBJECTIVES: We aim to quantify the performance of accelerometry in objectively measuring physical activity (PA) intensity among infants and toddlers. METHODS: Thirty-eight 6- to 24-month-olds participated in a 30-min, semistructured lab visit. Twenty-three (61%) children could walk independently. Children engaged in a variety of activities while wearing accelerometers on each ankle and at the waist. Visits were video recorded, and study team members independently coded the first three 5-s epochs of each minute for PA intensity using a 5-level scale ranging from 1 = completely sedentary to 5 = moderate-to-high intensity. Interrater agreement for PA classifications was excellent (median kappa per child = 0.85). A series of logistic regression models were fit to find the vector magnitude threshold per 5-s epoch that differentiated activity intensity above each PA level with >/= 80% sensitivity. RESULTS: Analyses included 3191 epochs; a median of 88 epochs per child. The classification performance applying all thresholds concurrently for the five PA intensity levels was poor for each wear location (agreement < 50%, kappa < 0.25). Classification improved when concatenating intensity levels, with the best performance comparing sedentary (levels 1-2) to nonsedentary (levels 3-5) and using data from the left ankle device: agreement >/= 77.6%, kappa >/= 0.44. Applying those novel thresholds to predict the total time spent in level 3-5 activities over all coded epochs using linear regression performed as well as using the sum of vector magnitude across epochs when using data from the left ankle device. Overall, the performance of the left ankle wear location was similar to the right ankle wear location and superior to the waist location. CONCLUSIONS: Ankle-worn accelerometry had adequate validity to classify in-the-moment nonsedentary behaviours and total time spent nonsedentary over a time interval among this sample of infants and toddlers. While caution is warranted when generalizing these lab-based findings to naturalistic settings, findings provide insight into objective measures of PA for this age range. CI - (c) 2025 The Author(s). Child: Care, Health and Development published by John Wiley & Sons Ltd. FAU - Dorris, Hannah J AU - Dorris HJ AUID- ORCID: 0009-0009-6455-8007 AD - Quantitative Biomedical Sciences Graduate Program, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire, USA. FAU - Carlson, Delaina D AU - Carlson DD AD - Department of Epidemiology, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire, USA. FAU - Ballarino, Grace A AU - Ballarino GA AD - Department of Epidemiology, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire, USA. FAU - Lopez, Nanette V AU - Lopez NV AD - Department of Health Sciences, Northern Arizona University, Flagstaff, Arizona, USA. FAU - Emond, Jennifer A AU - Emond JA AD - Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire, USA. AD - Department of Pediatrics, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire, USA. LA - eng GR - P30 CA023108/CA/NCI NIH HHS/United States GR - R03 DK131154/DK/NIDDK NIH HHS/United States GR - R03DK131154/DK/NIDDK NIH HHS/United States PT - Journal Article PL - England TA - Child Care Health Dev JT - Child: care, health and development JID - 7602632 SB - IM MH - Humans MH - Male MH - Female MH - *Accelerometry/methods/instrumentation MH - Child, Preschool MH - Infant MH - *Exercise/physiology MH - Ankle MH - Reproducibility of Results PMC - PMC11730355 OTO - NOTNLM OT - accelerometry OT - ankle OT - infants OT - physical activity OT - toddlers COIS- The funder had no role in the conceptualization, design, data collection, analysis, decision to publish, or preparation of the manuscript. The authors declare no conflicts of interest. EDAT- 2025/01/14 06:16 MHDA- 2025/01/14 06:17 PMCR- 2025/01/14 CRDT- 2025/01/14 00:33 PHST- 2024/12/05 00:00 [revised] PHST- 2024/06/12 00:00 [received] PHST- 2024/12/19 00:00 [accepted] PHST- 2025/01/14 06:17 [medline] PHST- 2025/01/14 06:16 [pubmed] PHST- 2025/01/14 00:33 [entrez] PHST- 2025/01/14 00:00 [pmc-release] AID - CCH70035 [pii] AID - 10.1111/cch.70035 [doi] PST - ppublish SO - Child Care Health Dev. 2025 Jan;51(1):e70035. doi: 10.1111/cch.70035. PMID- 39806399 OWN - NLM STAT- MEDLINE DCOM- 20250501 LR - 20260527 IS - 1475-2840 (Electronic) IS - 1475-2840 (Linking) VI - 24 IP - 1 DP - 2025 Jan 13 TI - Longitudinal DNA methylation profiles in saliva of offspring from mothers with gestational diabetes: associations with early childhood growth patterns. PG - 15 LID - 10.1186/s12933-024-02568-6 [doi] LID - 15 AB - BACKGROUND: The prevalence of obesity and type 2 diabetes mellitus (T2DM) is rising globally, particularly among children exposed to adverse intrauterine environments, such as those associated with gestational diabetes mellitus (GDM). Epigenetic modifications, specifically DNA methylation, have emerged as mechanisms by which early environmental exposures can predispose offspring to metabolic diseases. This study aimed to investigate DNA methylation differences in children born to mothers with GDM compared to non-GDM mothers, using saliva samples, and to assess the association of these epigenetic patterns with early growth measurements. METHODS: This study analyzed saliva DNA methylation patterns in 30 children (15 born to GDM mothers and 15 to non-GDM mothers) from the EPIDG cohort. Samples were collected at two time points: 8-10 weeks postpartum and at one year of age. Epigenome-wide analysis of over 850,000 CpG sites was conducted using the Illumina Methylation EPIC Bead Chip. Differential methylation positions (DMPs) were identified with the limma package, using a significance threshold of p < 0.01 and delta beta >/= 5%. Correlation analysis examined associations between methylation and growth variables (weight, height, BMI and annual growth) using Spearman tests. RESULTS: We identified 6,968 DMPs at the postpartum stage and 5,132 after one year, with 50 sites remaining differentially methylated over time, 16 of which maintained consistent methylation directionality. Functional analysis linked several of these DMPs to genes involved in inflammation and metabolic processes, including CYTH3 and FARP2, both implicated in growth and metabolic pathways. Significant correlations were found between specific CpG sites and growth-related variables such as weight, head circumference, height, and BMI. CONCLUSIONS: This study's longitudinal design reveals stable DNA methylation patterns in saliva samples that differentiate GDM-exposed children from controls across the first year of life, highlighting the feasibility of saliva as a minimally invasive biomarker source. The persistence of these epigenetic signatures underscores their potential as early indicators of metabolic risk, offering valuable insights into the long-term impact of maternal GDM on child health. Although the use of saliva offers a practical and non-invasive tool for pediatric epigenetic research, further studies are necessary to validate these findings in larger populations. CI - (c) 2025. The Author(s). FAU - Linares-Pineda, Teresa M AU - Linares-Pineda TM AD - Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010, Malaga, Spain. AD - CIBER Pathophysiology of Obesity and Nutrition-CIBERON, Instituto de Salud Carlos III, 28029, Madrid, Spain. AD - Biomedical Research Institute-IBIMA Plataforma BIONAND, 29010, Malaga, Spain. FAU - Lendinez-Jurado, Alfonso AU - Lendinez-Jurado A AD - Biomedical Research Institute-IBIMA Plataforma BIONAND, 29010, Malaga, Spain. AD - Andalucia Tech, Universidad de Malaga, Campus de Teatinos s/n, 29071, Malaga, Spain. AD - Department of Pediatric Endocrinology, Regional University Hospital of Malaga, 29011, Malaga, Spain. AD - Distrito Sanitario Malaga-Guadalhorce, 29009, Malaga, Spain. FAU - Piserra-Lopez, Alberto AU - Piserra-Lopez A AD - Department of Cardiology, Virgen de la Victoria University Hospital, Malaga, 29010, Spain. FAU - Suarez-Arana, Maria AU - Suarez-Arana M AD - Department of Obstetrics and Gynecology, Regional University Hospital of Malaga, Malaga, 29011, Spain. FAU - Pozo, Maria AU - Pozo M AD - Biomedical Research Institute-IBIMA Plataforma BIONAND, 29010, Malaga, Spain. FAU - Molina-Vega, Maria AU - Molina-Vega M AD - Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010, Malaga, Spain. FAU - Picon-Cesar, Maria Jose AU - Picon-Cesar MJ AD - Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010, Malaga, Spain. AD - CIBER Pathophysiology of Obesity and Nutrition-CIBERON, Instituto de Salud Carlos III, 28029, Madrid, Spain. AD - Biomedical Research Institute-IBIMA Plataforma BIONAND, 29010, Malaga, Spain. FAU - Morcillo, Sonsoles AU - Morcillo S AD - Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010, Malaga, Spain. sonsoles75@gmail.com. AD - CIBER Pathophysiology of Obesity and Nutrition-CIBERON, Instituto de Salud Carlos III, 28029, Madrid, Spain. sonsoles75@gmail.com. AD - Biomedical Research Institute-IBIMA Plataforma BIONAND, 29010, Malaga, Spain. sonsoles75@gmail.com. LA - eng GR - FI19/00178/Instituto de Salud Carlos III/ GR - JR20-00040/Instituto de Salud Carlos III/ GR - RC-0008-2021/Servicio Andaluz de Salud/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250113 PL - England TA - Cardiovasc Diabetol JT - Cardiovascular diabetology JID - 101147637 SB - IM MH - Humans MH - *DNA Methylation MH - *Diabetes, Gestational/diagnosis/genetics/metabolism MH - Female MH - Pregnancy MH - *Saliva/metabolism MH - *Epigenesis, Genetic MH - *Prenatal Exposure Delayed Effects MH - Male MH - Infant MH - *Child Development MH - Longitudinal Studies MH - Case-Control Studies MH - CpG Islands MH - Adult MH - Time Factors MH - Age Factors MH - Phenotype PMC - PMC11730480 OTO - NOTNLM OT - Child growth OT - Dna methylation OT - Epigenetic OT - Gestational diabetes OT - Offspring OT - Saliva COIS- Declarations. Competing interests: The authors declare no competing interests. Institutional Review Board Statement: The study was approved by the Institutional Review Board at the Hospital Universitario Virgen de la Victoria de Malaga, Spain, in accordance with the Declaration of Helsinki. The legal guardians are Dr. Sonsoles Morcillo and Dr. Maria Jose Picon. Informed consent: Informed consent was obtained from all subjects. EDAT- 2025/01/14 00:20 MHDA- 2025/01/14 06:16 PMCR- 2025/01/13 CRDT- 2025/01/13 23:38 PHST- 2024/11/08 00:00 [received] PHST- 2024/12/29 00:00 [accepted] PHST- 2025/01/14 06:16 [medline] PHST- 2025/01/14 00:20 [pubmed] PHST- 2025/01/13 23:38 [entrez] PHST- 2025/01/13 00:00 [pmc-release] AID - 10.1186/s12933-024-02568-6 [pii] AID - 2568 [pii] AID - 10.1186/s12933-024-02568-6 [doi] PST - epublish SO - Cardiovasc Diabetol. 2025 Jan 13;24(1):15. doi: 10.1186/s12933-024-02568-6. PMID- 39802444 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250114 IS - 2475-2991 (Electronic) IS - 2475-2991 (Linking) VI - 9 IP - 1 DP - 2025 Jan TI - The Minimum Dietary Diversity For Women Indicator Can Be Extended To Children And Adolescents aged 4-15 Years As A Proxy Population Indicator For Good Micronutrient Adequacy Of Diets In Low- and Middle-Income Countries. PG - 104508 LID - 10.1016/j.cdnut.2024.104508 [doi] LID - 104508 AB - BACKGROUND: The response to the global call for more data on children's and adolescents' diets and nutrition is limited by the lack of straightforward practical indicators to track their diet quality. On the basis of a food group score compiled from 10 food groups (FGS-10), the minimum dietary diversity for women, calculated as FGS-10 >/= 5, is a validated proxy population indicator for better micronutrient intake adequacy for adult women in low- and middle-income countries (LMICs). OBJECTIVES: This study aims to validate FGS-10 and its related cutoffs against micronutrient intake adequacy in 4-15-y-old children/adolescents in LMICs. METHODS: We conducted a secondary data analysis of 9 datasets of repeated 24-h recalls or weighed records including 11,524 children/adolescents aged 4-15 y, collected in 7 countries (Burkina Faso, Ghana, Ecuador, India, Malawi, Uganda, and Zambia) between 2007 and 2022. For each dataset and the pooled sample (meta-analysis), we assessed the association between FGS-10 and the mean probability of adequacy (MPA) of intake over 8 micronutrients (MPA-8), and the performance of several FGS-10 cutoffs in predicting acceptable (>/=0.60) and good (>/=0.80) levels of MPA-8. Robustness analyses used the 7 datasets with data on 11 micronutrients (MPA-11). RESULTS: FGS-10 ranged from 3.0 to 4.8 across datasets, and the proportion of children/adolescents with acceptable MPA-8 ranged from 8.4% to 74%. Positive and significant associations between FGS-10 and MPA-8 were found in all datasets and the pooled sample. The optimal cutoff varied across datasets from FGS-10 >/= 4 to FGS-10 >/= 6. In the pooled sample, FGS-10 >/= 5 had the highest performances in predicting acceptable and good levels of MPA-8. FGS-10 >/= 5 was also the best proxy indicator for MPA-11 >/= 0.80. CONCLUSIONS: The continuous FGS-10 and dichotomous FGS-10 >/= 5 may be extended to 4-15-y-old children/adolescents in LMICs. In this population, FGS-10 >/= 5 can be used as a proxy population indicator for good micronutrient adequacy of diets. CI - (c) 2024 The Authors. Published by Elsevier Inc. on behalf of American Society for Nutrition. FAU - Diop, Loty AU - Diop L AD - International Food Policy Research Institute (IFPRI), Washington, DC, United States. AD - Department of Food Technology, Safety and Health, Ghent University, Ghent, Belgium. FAU - Gelli, Aulo AU - Gelli A AD - International Food Policy Research Institute (IFPRI), Washington, DC, United States. FAU - Huybregts, Lieven AU - Huybregts L AD - International Food Policy Research Institute (IFPRI), Washington, DC, United States. AD - Department of Food Technology, Safety and Health, Ghent University, Ghent, Belgium. FAU - Arsenault, Joanne E AU - Arsenault JE AD - Intake-Center for Dietary Assessment at FHI360, Washington, DC, United States. FAU - Bliznashka, Lilia AU - Bliznashka L AD - International Food Policy Research Institute (IFPRI), Washington, DC, United States. FAU - Boy, Erick AU - Boy E AD - International Food Policy Research Institute (IFPRI), Washington, DC, United States. FAU - Deitchler, Megan AU - Deitchler M AD - Intake-Center for Dietary Assessment at FHI360, Washington, DC, United States. FAU - Lachat, Carl AU - Lachat C AD - Department of Food Technology, Safety and Health, Ghent University, Ghent, Belgium. FAU - Moursi, Mourad AU - Moursi M AD - Intake-Center for Dietary Assessment at FHI360, Washington, DC, United States. FAU - Ochoa-Aviles, Angelica M AU - Ochoa-Aviles AM AD - Department of Bioscience, Universidad de Cuenca, Loja, Cuenca, Ecuador. FAU - Olney, Deanna K AU - Olney DK AD - International Food Policy Research Institute (IFPRI), Washington, DC, United States. FAU - Becquey, Elodie AU - Becquey E AD - International Food Policy Research Institute (IFPRI), Washington, DC, United States. LA - eng PT - Journal Article DEP - 20241120 PL - United States TA - Curr Dev Nutr JT - Current developments in nutrition JID - 101717957 PMC - PMC11719312 OTO - NOTNLM OT - adolescents OT - children OT - low- and middle-income countries OT - micronutrient intake adequacy OT - minimum dietary diversity OT - usual intake COIS- The authors report no conflicts of interest. EDAT- 2025/01/13 06:16 MHDA- 2025/01/13 06:17 PMCR- 2024/11/20 CRDT- 2025/01/13 05:30 PHST- 2024/07/31 00:00 [received] PHST- 2024/11/07 00:00 [revised] PHST- 2024/11/10 00:00 [accepted] PHST- 2025/01/13 06:17 [medline] PHST- 2025/01/13 06:16 [pubmed] PHST- 2025/01/13 05:30 [entrez] PHST- 2024/11/20 00:00 [pmc-release] AID - S2475-2991(24)02442-9 [pii] AID - 104508 [pii] AID - 10.1016/j.cdnut.2024.104508 [doi] PST - epublish SO - Curr Dev Nutr. 2024 Nov 20;9(1):104508. doi: 10.1016/j.cdnut.2024.104508. eCollection 2025 Jan. PMID- 39800311 OWN - NLM STAT- MEDLINE DCOM- 20250731 LR - 20260519 IS - 1541-6100 (Electronic) IS - 0022-3166 (Linking) VI - 155 IP - 8 DP - 2025 Aug TI - Dietary Reference Intakes of Selenium for Chinese Residents. PG - 2508-2518 LID - S0022-3166(25)00014-8 [pii] LID - 10.1016/j.tjnut.2025.01.008 [doi] AB - The plasma selenoprotein P (SELENOP) concentration leveling out was thought to represent saturation of the functional selenium body pool and an appropriate supply of selenium to all tissues, indicating that the necessary amount of selenium had been supplied. Based on the selenium intake when SELENOP reaches saturation, the estimated average requirement of selenium was set as 50 mug/d, and the recommended nutrient intake was 60 mug/d for Chinese general population. According to a recent study, "lactating Chinese women with the optimal daily selenium intake" was defined, and the adequate intake of 0‒6-mo-old infants was set as 15 mug/d, whereas 20 mug/d was calculated for 7‒12 mo old infants. Considering the negative health effects of intake of excessive nutrient levels of selenium, we recommend reducing the tolerable upper intake level (UL) for adults from 400 to 255 mug/d based on the results of the Selenium and Vitamin E Cancer Prevention Trial (SELECT). The SELECT trial is a key basis for setting selenium's UL. It has a large sample size and long-term design. It rigorously measures selenium intake and monitors multiple health endpoints precisely. Also, with proper control groups, it effectively determines the threshold of adverse effects, enhancing the reliability of UL determination. CI - Copyright (c) 2025. Published by Elsevier Inc. FAU - Han, Feng AU - Han F AD - National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, NHC Key Laboratory of Public Nutrition and Health, Beijing, 100050, China. FAU - Liu, Yiqun AU - Liu Y AD - National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, NHC Key Laboratory of Public Nutrition and Health, Beijing, 100050, China. FAU - Wang, Qin AU - Wang Q AD - National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, NHC Key Laboratory of Public Nutrition and Health, Beijing, 100050, China. FAU - Huang, Zhenwu AU - Huang Z AD - National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, NHC Key Laboratory of Public Nutrition and Health, Beijing, 100050, China. Electronic address: huangzw@ninh.chinacdc.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250110 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 RN - H6241UJ22B (Selenium) RN - 0 (Selenoprotein P) RN - Chinese people SB - IM MH - Humans MH - *Selenium/administration & dosage/blood MH - China MH - *Recommended Dietary Allowances MH - Female MH - Infant MH - Adult MH - *Diet MH - Selenoprotein P/blood MH - Male MH - Nutritional Status MH - East Asian People OTO - NOTNLM OT - adequate intake OT - dietary reference intakes OT - recommended nutrient intake OT - selenium OT - tolerable upper intake level COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2025/01/13 00:20 MHDA- 2025/08/01 00:29 CRDT- 2025/01/12 19:34 PHST- 2024/11/04 00:00 [received] PHST- 2025/01/06 00:00 [revised] PHST- 2025/01/07 00:00 [accepted] PHST- 2025/08/01 00:29 [medline] PHST- 2025/01/13 00:20 [pubmed] PHST- 2025/01/12 19:34 [entrez] AID - S0022-3166(25)00014-8 [pii] AID - 10.1016/j.tjnut.2025.01.008 [doi] PST - ppublish SO - J Nutr. 2025 Aug;155(8):2508-2518. doi: 10.1016/j.tjnut.2025.01.008. Epub 2025 Jan 10. PMID- 39800225 OWN - NLM STAT- MEDLINE DCOM- 20250430 LR - 20260804 IS - 1874-1754 (Electronic) IS - 0167-5273 (Linking) VI - 422 DP - 2025 Mar 1 TI - Cardiopulmonary exercise testing in children and adolescents at moderate altitude: New normative values. PG - 132977 LID - S0167-5273(25)00020-8 [pii] LID - 10.1016/j.ijcard.2025.132977 [doi] AB - BACKGROUND: Cardiopulmonary exercise tests (CPETs) measure cardiovascular exercise response. Altitude alters exercise parameters, so standard normative datasets (Cooper, Bruce, Burstein) may not accurately predict exercise parameters for data collected at moderate altitude. This study aimed to: 1) establish modern normative exercise values for children/adolescents at moderate altitude and 2) compare these values against the Cooper, Burstein and Bruce models. METHODS: Maximal CPETs in children/adolescents aged 6 to 18 years were evaluated retrospectively (n = 1154, mean age 13.92 +/- 2.70 years, 49.7 % female). Separate analysis and modeling were completed for the cycle ergometer (n = 907) and treadmill (n = 247). Polynomial regression models were developed for each exercise variable. A validation cohort of tests on the treadmill and cycle ergometer (n = 100, 50 cycle ergometer, 50 treadmill, mean age 14.44 +/- 2.57 years, 47.0 % female) were evaluated with our polynomial models. RESULTS: On the cycle ergometer, the Burstein dataset had improved root mean square error (RMSE, 7.4) compared to the Cooper dataset (RMSE 9.6) for peak oxygen consumption (VO(2) peak), while our model demonstrated even better RMSE (5.5). Our model had improved RMSE compared to the Burstein equations for all parameters (except resting systolic blood pressure) indicating an improved model. CONCLUSIONS: We present new normative data and predictive equations based on a relatively large population of healthy children/adolescents tested at moderate altitude that outperforms sea-level-based models. Among other variables (age, gender, BMI, ethnicity), altitude must be considered when reporting exercise data so that normal CPET values at moderate altitude are not misinterpreted as pathological CPET findings. CI - Copyright (c) 2024. Published by Elsevier B.V. FAU - Fernie, Julie C AU - Fernie JC AD - Children's Hospital Colorado Heart Institute, Aurora, CO, USA. FAU - Silveira, Lori J AU - Silveira LJ AD - University of Colorado School of Medicine, Aurora, CO, USA. FAU - Jacobsen, Roni AU - Jacobsen R AD - Children's Hospital Colorado Heart Institute, Aurora, CO, USA; University of Colorado School of Medicine, Aurora, CO, USA. FAU - Rausch, Christopher M AU - Rausch CM AD - Children's Hospital Colorado Heart Institute, Aurora, CO, USA; University of Colorado School of Medicine, Aurora, CO, USA. Electronic address: christopher.rausch@childrenscolorado.org. LA - eng PT - Journal Article DEP - 20250110 PL - Netherlands TA - Int J Cardiol JT - International journal of cardiology JID - 8200291 SB - IM MH - Humans MH - Adolescent MH - Child MH - Female MH - *Exercise Test/methods/standards MH - Male MH - *Altitude MH - Retrospective Studies MH - *Oxygen Consumption/physiology MH - Reference Values MH - Exercise Tolerance/physiology OTO - NOTNLM OT - Adolescents OT - Altitude OT - Children OT - Exercise capacity OT - Exercise testing OT - Pediatric COIS- Declaration of competing interest The authors have no conflicts of interest relevant to this article to disclose. EDAT- 2025/01/13 00:20 MHDA- 2025/02/06 00:20 CRDT- 2025/01/12 19:33 PHST- 2024/11/15 00:00 [received] PHST- 2024/12/17 00:00 [revised] PHST- 2025/01/08 00:00 [accepted] PHST- 2025/02/06 00:20 [medline] PHST- 2025/01/13 00:20 [pubmed] PHST- 2025/01/12 19:33 [entrez] AID - S0167-5273(25)00020-8 [pii] AID - 10.1016/j.ijcard.2025.132977 [doi] PST - ppublish SO - Int J Cardiol. 2025 Mar 1;422:132977. doi: 10.1016/j.ijcard.2025.132977. Epub 2025 Jan 10. PMID- 39798930 OWN - NLM STAT- MEDLINE DCOM- 20250430 LR - 20260530 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 206 DP - 2025 Feb 1 TI - Towards developing a "baby translator" - An exploration of how infant appetite cues are understood. PG - 107850 LID - S0195-6663(25)00002-9 [pii] LID - 10.1016/j.appet.2025.107850 [doi] AB - Caregivers' feeding practices shape their child's eating patterns and subsequent health. Research shows that sensitive feeding is linked to healthy development and self-regulation but depends on caregiver responsiveness to infant needs and appetite cues. Responsive feeding (RF) is influenced both by characteristics of the caregiver and expressiveness of the infant. To investigate how infant communication is understood and whether recognition of appetite cues is associated with the viewer's eating traits, mental health and wellbeing, an online study was conducted. Participants (N = 200) aged 18-55 years were recruited in June 2022 via Prolific. Recognition of infant appetite cues was measured by participant responses to video clips of infants (N = 10) being fed during mealtimes (sampled at the start and end of a meal). Caregiver satiety responsiveness, intuitive eating, alexithymia, autism spectrum disorder, and mental health were assessed by validated questionnaires. Results showed a high consensus in identifying infant appetite cues, with no significant correlations with parenting status, eating traits or mental health, except for one subscale of alexithymia - Difficulty Describing Feelings (r = -.15, p = .03). Open-ended descriptions of mealtime cues showed that positive affect was observed early in the meal and more negative affect at the end of the meal. Infant cues signalling interest in eating were generally well recognised and were not significantly correlated with individual differences of the viewer except alexithymia. Further research to assess the association between alexithymia, responsiveness to infant communication cues and RF practices is warranted. CI - Copyright (c) 2025. Published by Elsevier Ltd. FAU - Yu, Shihui AU - Yu S AD - School of Psychology, University of Leeds, Leeds, LS2 9JT, UK. FAU - Birtill, Pam AU - Birtill P AD - School of Psychology, University of Leeds, Leeds, LS2 9JT, UK. FAU - Fildes, Alison AU - Fildes A AD - School of Psychology, University of Leeds, Leeds, LS2 9JT, UK. FAU - Tang, Tang AU - Tang T AD - School of Design, University of Leeds, Leeds, LS2 9JT, UK. FAU - Hetherington, Marion M AU - Hetherington MM AD - School of Psychology, University of Leeds, Leeds, LS2 9JT, UK. Electronic address: m.hetherington@leeds.ac.uk. LA - eng PT - Journal Article DEP - 20250109 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - Adult MH - *Cues MH - Male MH - *Appetite MH - Adolescent MH - Young Adult MH - *Feeding Behavior/psychology MH - Infant MH - Middle Aged MH - Meals/psychology MH - Surveys and Questionnaires MH - Caregivers/psychology OTO - NOTNLM OT - Alexithymia OT - Appetite cues OT - Infants OT - Responsive feeding OT - Satiety responsiveness COIS- Declaration of competing interest This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The authors declare no competing interests regarding this research. EDAT- 2025/01/12 15:21 MHDA- 2025/01/26 02:11 CRDT- 2025/01/11 19:30 PHST- 2024/06/14 00:00 [received] PHST- 2024/12/31 00:00 [revised] PHST- 2025/01/03 00:00 [accepted] PHST- 2025/01/26 02:11 [medline] PHST- 2025/01/12 15:21 [pubmed] PHST- 2025/01/11 19:30 [entrez] AID - S0195-6663(25)00002-9 [pii] AID - 10.1016/j.appet.2025.107850 [doi] PST - ppublish SO - Appetite. 2025 Feb 1;206:107850. doi: 10.1016/j.appet.2025.107850. Epub 2025 Jan 9. PMID- 39798864 OWN - NLM STAT- MEDLINE DCOM- 20250624 LR - 20250911 IS - 2212-2672 (Print) IS - 2212-2672 (Linking) VI - 125 IP - 7 DP - 2025 Jul TI - Effects of Nutrition-Specific Interventions to Prevent and Control Nutrition-Related Anemia in Infants, Children, and Adolescents: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. PG - 964-983.e13 LID - S2212-2672(25)00002-4 [pii] LID - 10.1016/j.jand.2025.01.002 [doi] AB - BACKGROUND: Anemia is a prevalent health issue among children and adolescents worldwide, with malnutrition being among the most common causes. Nutrition-related anemia can be prevented or controlled through targeted interventions. OBJECTIVE: This study aimed to evaluate the effects of nutrition interventions on ferritin concentration, hemoglobin concentration, anemia prevalence, and nutrition-related anemia prevalence in infants, children, and adolescents-and to compare outcomes by intervention and age group using network meta-analysis of randomized controlled trials. METHODS: Web of Science, PubMed, Scopus, EBSCO, the Cochrane Library, China National Knowledge Infrastructure Database, Weipu Database, and Wanfang Database were comprehensively searched to identify randomized controlled trials on the effects of nutrition interventions (micronutrient supplementation, macronutrient supplementation, and nutrition education) until September 30, 2023. Two groups of researchers screened the literature and extracted data based on set inclusion and exclusion criteria. Reviewers used the Cochrane tool for assessing risk-of-bias in randomized controlled trials and used the Grading of Recommendations, Assessment, Development, and Evaluation for evaluating the strength of evidence for inclusion in network meta-analysis. The study population was categorized into infants and preschool-aged children (aged 6 to 59 months), school-aged children (aged 6 to 11 years), and adolescents (aged 12 to 18 years). The study evaluated the mean difference, risk ratio, and 95% credible interval of outcomes for each intervention across different age groups using network meta-analysis. RESULTS: Sixty-one randomized controlled trials were included in this analysis. In network meta-analysis, micronutrient supplementation, macronutrient supplementation, and nutrition education were found to have significant effects on hemoglobin concentrations in infants and preschool-aged children. Lipid-based nutrient supplementation resulted in the highest increase in hemoglobin concentration, whereas multiple micronutrient supplementation resulted in the largest reduction in risk of anemia and iron deficiency anemia. In school-aged children, iron supplementation increased hemoglobin concentration, whereas micronutrient supplementation also increased hemoglobin concentration and reduced anemia risk. In adolescents, iron supplementation improved hemoglobin concentration and lowered anemia risk. CONCLUSIONS: The effectiveness of nutrition interventions in improving nutrition-related anemia varies across intervention types and age groups. Micronutrient and iron supplementation consistently improved hemoglobin levels and related indicators, with evidence quality ranging from low to moderate. MMN and LNS had positive effects on hemoglobin concentrations and anemia in infants and preschool-aged children, which is supported by low-to-moderate quality evidence. For adolescents, although micronutrient and iron supplementation showed positive effects, the overall evidence quality was generally low, highlighting the need for further high-quality clinical research to validate these findings. CI - Copyright (c) 2025 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Ren, Ting AU - Ren T AD - School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu, China. FAU - Lu, Yuqiong AU - Lu Y AD - School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu, China. FAU - Dai, Zhanjing AU - Dai Z AD - School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu, China. FAU - Yang, Jing AU - Yang J AD - School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu, China. FAU - Wu, Yuhang AU - Wu Y AD - School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu, China. FAU - Chang, Feng AU - Chang F AD - School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu, China. FAU - Wang, Sida AU - Wang S AD - School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu, China. FAU - Wang, Linyun AU - Wang L AD - School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu, China. FAU - Lu, Yun AU - Lu Y AD - School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu, China. Electronic address: luyuncpu@163.com. LA - eng PT - Journal Article PT - Network Meta-Analysis PT - Systematic Review DEP - 20250109 PL - United States TA - J Acad Nutr Diet JT - Journal of the Academy of Nutrition and Dietetics JID - 101573920 RN - 9007-73-2 (Ferritins) RN - 0 (Hemoglobins) RN - 0 (Micronutrients) SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - *Anemia/prevention & control/etiology/epidemiology MH - Anemia, Iron-Deficiency/prevention & control MH - Dietary Supplements MH - Ferritins/blood MH - Hemoglobins/analysis MH - Micronutrients/administration & dosage MH - *Nutrition Therapy/methods MH - Nutritional Status MH - Prevalence MH - Randomized Controlled Trials as Topic OTO - NOTNLM OT - Macronutrient OT - Meta-analysis OT - Micronutrient OT - Nutrition education OT - Nutrition-related anemia EDAT- 2025/01/12 15:21 MHDA- 2025/06/24 11:10 CRDT- 2025/01/11 19:29 PHST- 2023/11/29 00:00 [received] PHST- 2025/01/01 00:00 [revised] PHST- 2025/01/03 00:00 [accepted] PHST- 2025/06/24 11:10 [medline] PHST- 2025/01/12 15:21 [pubmed] PHST- 2025/01/11 19:29 [entrez] AID - S2212-2672(25)00002-4 [pii] AID - 10.1016/j.jand.2025.01.002 [doi] PST - ppublish SO - J Acad Nutr Diet. 2025 Jul;125(7):964-983.e13. doi: 10.1016/j.jand.2025.01.002. Epub 2025 Jan 9. PMID- 39798013 OWN - NLM STAT- MEDLINE DCOM- 20250111 LR - 20250521 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 184 IP - 2 DP - 2025 Jan 11 TI - Validity of the MED4CHILD tool for assessing adherence to the Mediterranean diet in preschool children. PG - 130 LID - 10.1007/s00431-024-05945-1 [doi] LID - 130 AB - Most of the available tools to assess adherence to Mediterranean diet (MedDiet) were constructed for adults, having limited applicability to children and adolescents. The aim of this study is to validate a specific questionnaire to assess adherence to MedDiet in children aged 3 to 6 years (MED4CHILD questionnaire). The validation was performed in a baseline examination of a cohort of children who were recruited in schools in seven cities. Of the total sample of 1509 children, we included 858 children aged 3 to 6 years with complete information on adherence to the MedDiet, food consumption, anthropometry and cardiometabolic characteristics. Adherence to the MedDiet was assessed using an 18-item questionnaire, adapted from validated questionnaire for adults using the Delphi method. Food and beverage consumption was assessed using a validated COME-Kids Food and Beverage Frequency Questionnaire. Anthropometric measurements and cardiometabolic risk factors were assessed using standard methods. Statistical analyses included kappa agreement, ANOVA and linear regression models. Higher MED4CHILD scores were associated with higher intakes of food characteristic of the MedDiet. The MED4CHILD questionnaire showed moderate validity, especially for key items of the Mediterranean diet (kappa ranging from 0.333 to 0.665). Direct significant associations were found between MED4CHILD scores and cardiometabolic profile, including waist circumference (p), triglycerides and HOMA-IR (p < 0.05). CONCLUSION: The 18-item MED4CHILD questionnaire showed moderate validity for assessing adherence to the MedDiet in children aged 3 to 6 years, in terms of agreement with food and beverage consumption and favourable cardiometabolic profile. WHAT IS KNOWN: * The Mediterranean diet has been linked to a number of health benefits and the assessment of children's adherence to this diet is important for public health and research. * The tools available to assess MedDiet compliance are mainly for adults. WHAT IS NEW: * The MED4CHILD questionnaire is a simple, inexpensive and rapid tool for assessing MedDiet compliance in children. * This tool showed moderate relative validity and a high score was associated with a favourable cardiometabolic profile. CI - (c) 2025. The Author(s). FAU - Larruy-Garcia, Alicia AU - Larruy-Garcia A AUID- ORCID: 0000-0002-2165-5263 AD - Growth, Exercise, Nutrition and Development (GENUD) Research Group, Instituto Agroalimentario de Aragon (IA2), Faculty of Health Sciences, Universidad de Zaragoza, Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), 50009, Saragossa, Spain. FAU - De Miguel-Etayo, Pilar AU - De Miguel-Etayo P AUID- ORCID: 0000-0001-6173-5850 AD - Growth, Exercise, Nutrition and Development (GENUD) Research Group, Instituto Agroalimentario de Aragon (IA2), Faculty of Health Sciences, Universidad de Zaragoza, Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), 50009, Saragossa, Spain. AD - CIBER, Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. FAU - Babio, Nancy AU - Babio N AUID- ORCID: 0000-0003-3527-5277 AD - CIBER, Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. nancy.babio@urv.cat. AD - Universitat Rovira I Virgili, Unitat de Nutricio Humana. Grup ANUT‑DSM, Departament de Bioquimica i Biotecnologia, C/Sant Llorenc, 21, 43201, Reus, Spain. nancy.babio@urv.cat. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. nancy.babio@urv.cat. FAU - Flores-Rojas, Katherine AU - Flores-Rojas K AUID- ORCID: 0000-0001-8692-0702 AD - Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), University of Cordoba, 14004, Cordoba, Spain. FAU - Picans-Leis, Rosaura AU - Picans-Leis R AUID- ORCID: 0000-0003-4702-9962 AD - Instituto de Investigacion Sanitaria de Santiago (IDIS), Servicio de Neonatologia, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain. FAU - Gomez-Martinez, Carlos AU - Gomez-Martinez C AUID- ORCID: 0000-0002-3077-6702 AD - CIBER, Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. AD - Universitat Rovira I Virgili, Unitat de Nutricio Humana. Grup ANUT‑DSM, Departament de Bioquimica i Biotecnologia, C/Sant Llorenc, 21, 43201, Reus, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. FAU - Miguel-Berges, Maria L AU - Miguel-Berges ML AUID- ORCID: 0000-0002-2411-9538 AD - Growth, Exercise, Nutrition and Development (GENUD) Research Group, Instituto Agroalimentario de Aragon (IA2), Faculty of Health Sciences, Universidad de Zaragoza, Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), 50009, Saragossa, Spain. AD - CIBER, Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. FAU - Martinez, J Alfredo AU - Martinez JA AUID- ORCID: 0000-0001-5218-6941 AD - CIBER, Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. AD - Department of Nutrition Food Science & Physiology, University of Navarra, 31008, Pamplona, Spain. FAU - Corella, Dolores AU - Corella D AUID- ORCID: 0000-0002-2366-4104 AD - CIBER, Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. AD - Departamento de Medicina Preventiva, Facultad de Medicina, Universidad de Valencia, Valencia, Spain. FAU - de la Torre-Aguilar, M Jose AU - de la Torre-Aguilar MJ AUID- ORCID: 0000-0002-2473-0660 AD - Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), University of Cordoba, 14004, Cordoba, Spain. FAU - Vazquez-Cobela, Rocio AU - Vazquez-Cobela R AUID- ORCID: 0000-0002-3155-1601 AD - CIBER, Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. AD - Research Group of Pediatric Nutrition, Instituto de Investigacion Sanitaria de Santiago (IDIS), Unidad de Gastroenterologia, Hepatologia y Nutricion Pediatrica del Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain. AD - Unit of Investigation in Nutrition, Growth and Human Development of Galicia, University of Santiago de Compostela, Santiago de Compostela, Spain. FAU - Shyam, Sangeetha AU - Shyam S AUID- ORCID: 0000-0002-3340-1519 AD - CIBER, Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. AD - Universitat Rovira I Virgili, Unitat de Nutricio Humana. Grup ANUT‑DSM, Departament de Bioquimica i Biotecnologia, C/Sant Llorenc, 21, 43201, Reus, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. FAU - Pastor-Villaescusa, Belen AU - Pastor-Villaescusa B AUID- ORCID: 0000-0003-0817-6804 AD - CIBER, Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. AD - Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), University of Cordoba, 14004, Cordoba, Spain. FAU - Cordoba-Rodriguez, Diana Paola AU - Cordoba-Rodriguez DP AUID- ORCID: 0000-0002-7034-8796 AD - Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia Universidad Javeriana, 110231, Bogota, Colombia. FAU - Schroder, Helmut AU - Schroder H AUID- ORCID: 0000-0003-2231-5081 AD - Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain. AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain. FAU - Fernandez de la Puente, Maria AU - Fernandez de la Puente M AUID- ORCID: 0000-0002-7164-3420 AD - CIBER, Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. AD - Universitat Rovira I Virgili, Unitat de Nutricio Humana. Grup ANUT‑DSM, Departament de Bioquimica i Biotecnologia, C/Sant Llorenc, 21, 43201, Reus, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. FAU - Jurado-Castro, Jose Manuel AU - Jurado-Castro JM AUID- ORCID: 0000-0002-0198-2793 AD - CIBER, Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. AD - Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), University of Cordoba, 14004, Cordoba, Spain. FAU - Ni, Jiaqi AU - Ni J AUID- ORCID: 0000-0001-5625-0373 AD - CIBER, Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. AD - Universitat Rovira I Virgili, Unitat de Nutricio Humana. Grup ANUT‑DSM, Departament de Bioquimica i Biotecnologia, C/Sant Llorenc, 21, 43201, Reus, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. FAU - Navas-Carretero, Santiago AU - Navas-Carretero S AUID- ORCID: 0000-0002-5163-2230 AD - CIBER, Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. AD - Department of Nutrition Food Science & Physiology, University of Navarra, 31008, Pamplona, Spain. AD - University of Navarra, Center for Nutrition Research, 31008, Pamplona, Spain. AD - IdisNA, Navarra Institute for Health Research, Pamplona, Spain. FAU - Leis, Rosaura AU - Leis R AUID- ORCID: 0000-0002-0540-4210 AD - CIBER, Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. AD - Unit of Investigation in Nutrition, Growth and Human Development of Galicia, University of Santiago de Compostela, Santiago de Compostela, Spain. AD - Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia Universidad Javeriana, 110231, Bogota, Colombia. FAU - Gil-Campos, Mercedes AU - Gil-Campos M AUID- ORCID: 0000-0002-9007-0242 AD - CIBER, Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. AD - Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), University of Cordoba, 14004, Cordoba, Spain. FAU - Salas-Salvado, Jordi AU - Salas-Salvado J AUID- ORCID: 0000-0003-2700-7459 AD - CIBER, Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. AD - Universitat Rovira I Virgili, Unitat de Nutricio Humana. Grup ANUT‑DSM, Departament de Bioquimica i Biotecnologia, C/Sant Llorenc, 21, 43201, Reus, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. FAU - Moreno, Luis A AU - Moreno LA AUID- ORCID: 0000-0003-0454-653X AD - Growth, Exercise, Nutrition and Development (GENUD) Research Group, Instituto Agroalimentario de Aragon (IA2), Faculty of Health Sciences, Universidad de Zaragoza, Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), 50009, Saragossa, Spain. AD - CIBER, Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. LA - eng GR - Maria Zambrano/Ministry of Universities and the Recovery, Transformation and Resilience Plan/ GR - FPU 20/ 00385/Ministerio de Ciencia, Innovacion y Universidades/ GR - 2019/Instituto Danone/ PT - Journal Article PT - Validation Study DEP - 20250111 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Diet, Mediterranean/statistics & numerical data MH - Child, Preschool MH - Male MH - Female MH - Child MH - Surveys and Questionnaires MH - Reproducibility of Results MH - *Patient Compliance/statistics & numerical data MH - Diet Surveys MH - Cardiometabolic Risk Factors PMC - PMC11724776 OTO - NOTNLM OT - Childhood OT - Dietary intake OT - Mediterranean pattern OT - Short screener OT - Validation study COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/01/11 14:11 MHDA- 2025/01/11 14:12 PMCR- 2025/01/11 CRDT- 2025/01/11 11:14 PHST- 2024/07/23 00:00 [received] PHST- 2024/12/18 00:00 [accepted] PHST- 2024/12/12 00:00 [revised] PHST- 2025/01/11 14:12 [medline] PHST- 2025/01/11 14:11 [pubmed] PHST- 2025/01/11 11:14 [entrez] PHST- 2025/01/11 00:00 [pmc-release] AID - 10.1007/s00431-024-05945-1 [pii] AID - 5945 [pii] AID - 10.1007/s00431-024-05945-1 [doi] PST - epublish SO - Eur J Pediatr. 2025 Jan 11;184(2):130. doi: 10.1007/s00431-024-05945-1. PMID- 39797958 OWN - NLM STAT- MEDLINE DCOM- 20260530 LR - 20261010 IS - 1573-3432 (Electronic) IS - 0162-3257 (Linking) VI - 56 IP - 6 DP - 2026 Jun TI - Research Tools for Eating Behavior in People with Autism Spectrum Disorder (ASD). PG - 2126-2135 LID - 10.1007/s10803-024-06710-x [doi] AB - OBJECTIVE: To identify the tools used to assess eating behaviors in individuals with Autism Spectrum Disorder (ASD) and summarize their distribution, citation rates, journal publication, JCR scores, and psychometric properties. METHODS: A literature review was conducted to identify studies on eating behavior in individuals with ASD. The search included various descriptors and combinations of keywords in databases such as Medline/PubMed, Science Direct, Scopus, SciELO, and Web of Science. The studies were filtered to focus on articles published in the last five years. Thirty-seven relevant studies were identified and analyzed to summarize the tools used, their distribution in the literature, citation rates, and psychometric properties. RESULTS: Thirty-seven relevant studies were identified. The Journal of Autism and Developmental Disorders published the most studies (5). The Brief Autism Mealtime Behavior Inventory (BAMBI) was the most frequently used instrument, appearing in 15 studies, followed by the Behavioral Pediatrics Feeding Assessment Scale (BPFAS) in 8 studies. Both instruments demonstrated solid psychometric properties, with BAMBI showing good internal consistency (alpha = 0.88) and BPFAS a Cronbach's alpha of 0.82. CONCLUSION: Most of the instruments used in studies on eating behavior in individuals with ASD demonstrate satisfactory psychometric properties. BAMBI and BPFAS stand out for their widespread use but are limited to covering only specific age ranges. CI - (c) 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Milane, Nayara Cristina AU - Milane NC AUID- ORCID: 0000-0002-7858-4902 AD - Federal Technological University of Parana, Postgraduate Program in Science and Technology Teaching (PPGECT), Ponta Grossa, Parana, Brasil. nayaramilanenutri@gmail.com. FAU - Semensato, Michel Teston AU - Semensato MT AUID- ORCID: 0000-0002-9753-3406 AD - Federal Technological University of Parana, Postgraduate Program in Science and Technology Teaching (PPGECT), Ponta Grossa, Parana, Brasil. AD - Federal Technological University of Parana, Guarpuava, Parana, Brasil. FAU - Pilatti, Luiz Alberto AU - Pilatti LA AUID- ORCID: 0000-0003-2679-9191 AD - Federal Technological University of Parana, Postgraduate Program in Science and Technology Teaching (PPGECT), Ponta Grossa, Parana, Brasil. LA - eng PT - Journal Article PT - Review DEP - 20250111 PL - United States TA - J Autism Dev Disord JT - Journal of autism and developmental disorders JID - 7904301 SB - IM MH - Humans MH - *Autism Spectrum Disorder/psychology MH - *Feeding Behavior/psychology MH - Psychometrics MH - Child MH - Reproducibility of Results OTO - NOTNLM OT - Assessment Tools OT - Autism Spectrum Disorder OT - Feeding Behavior OT - Psychometric Validation COIS- Declarations. Competing Interests: The authors declare that they have no financial interests. EDAT- 2025/01/11 14:11 MHDA- 2026/05/31 05:31 CRDT- 2025/01/11 11:04 PHST- 2024/12/23 00:00 [accepted] PHST- 2026/05/31 05:31 [medline] PHST- 2025/01/11 14:11 [pubmed] PHST- 2025/01/11 11:04 [entrez] AID - 10.1007/s10803-024-06710-x [pii] AID - 10.1007/s10803-024-06710-x [doi] PST - ppublish SO - J Autism Dev Disord. 2026 Jun;56(6):2126-2135. doi: 10.1007/s10803-024-06710-x. Epub 2025 Jan 11. PMID- 39797665 OWN - NLM STAT- MEDLINE DCOM- 20250430 LR - 20260605 IS - 1552-4833 (Electronic) IS - 1552-4825 (Print) IS - 1552-4825 (Linking) VI - 197 IP - 5 DP - 2025 May TI - Inpatient Hospitalizations for COVID-19 Among Patients With Prader-Willi Syndrome: A National Inpatient Sample Analysis. PG - e63980 LID - 10.1002/ajmg.a.63980 [doi] AB - Prader-Willi syndrome (PWS) is a genetic disorder associated with baseline respiratory impairment caused by multiple contributing etiologies. While this may be expected to increase the risk of severe COVID-19 infections in PWS patients, survey studies have suggested paradoxically low disease severity. To better characterize the course of COVID-19 infection in patients with PWS, this study analyses the outcomes of hospitalizations for COVID-19 among patients with and without PWS. The National Inpatient Sample, an all-payors administrative claims database of hospitalizations in the United States, was queried for patients with a coded diagnosis COVID-19 in 2020 and 2021. Hospitalizations for patients with PWS compared to those for patients without PWS using Augmented Inverse Propensity Weighting (AIPW). There were 295 (95% CI: 228-362) COVID-19 hospitalizations for individuals with PWS and 4,112,400 (95% CI: 4,051,497-4,173,303) for individuals without PWS. PWS patients had a median age of 33 years compared to 63 for those without PWS. Individuals with PWS had higher baseline rates of obesity (47.5% vs. 28.4%). AIPW models show that PWS diagnosis is associated with increased hospital length of stay by 7.43 days, hospital charges by $80,126, and the odds of mechanical ventilation and in-hospital death (odds ratios of 1.79 and 1.67, respectively). PWS patients hospitalized with COVID-19 experienced longer hospital stays, higher charges, and increased risk of mechanical ventilation and death. These results suggest that PWS should be considered a risk factor for severe COVID-19, warranting continued protective measures and vaccination efforts. Further research is needed to validate coding for PWS and assess the impact of evolving COVID-19 variants and population immunity on this vulnerable population. CI - (c) 2025 Wiley Periodicals LLC. FAU - Luccarelli, James AU - Luccarelli J AD - Massachusetts General Hospital, Boston, Massachusetts, USA. AD - Harvard Medical School, Boston, Massachusetts, USA. FAU - Strong, Theresa V AU - Strong TV AUID- ORCID: 0000-0001-6783-8703 AD - Foundation for Prader-Willi Research, Covina, California, USA. FAU - Rubin, Emily B AU - Rubin EB AD - Massachusetts General Hospital, Boston, Massachusetts, USA. AD - Harvard Medical School, Boston, Massachusetts, USA. FAU - McCoy, Thomas H Jr AU - McCoy TH Jr AD - Massachusetts General Hospital, Boston, Massachusetts, USA. AD - Harvard Medical School, Boston, Massachusetts, USA. LA - eng GR - T32 MH112485/MH/NIMH NIH HHS/United States GR - Foundation for Prader-Willi Research/ GR - T32MH112485/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20250111 PL - United States TA - Am J Med Genet A JT - American journal of medical genetics. Part A JID - 101235741 SB - IM UOF - medRxiv. 2024 Sep 06:2024.09.06.24313191. doi: 10.1101/2024.09.06.24313191. PMID: 39281756 MH - Humans MH - *Prader-Willi Syndrome/complications/epidemiology/virology MH - *COVID-19/epidemiology/complications/virology/therapy MH - *Hospitalization/statistics & numerical data MH - Female MH - Male MH - Adult MH - Middle Aged MH - United States/epidemiology MH - SARS-CoV-2/pathogenicity MH - Adolescent MH - Inpatients/statistics & numerical data MH - Young Adult MH - Child MH - Child, Preschool MH - Aged MH - Risk Factors MH - Infant PMC - PMC12172633 MID - NIHMS2085345 OTO - NOTNLM OT - COVID-19 OT - Prader-Willi syndrome OT - causal inference OT - cohort studies OT - demography COIS- Conflicts of Interest JL receives funding from Harvard Medical School Dupont Warren Fellowship and Livingston Awards, the Rappaport Foundation, the American Academy of Child and Adolescent Psychiatry, and the Foundation for Prader-Willi Research. He has received equity and consulting fees from Revival Therapeutics, Inc. TVS is an employee of the Foundation for Prader-Willi Research. BBR has no disclosures to report. THM receives funding, through his institution, from National Institute of Health, Telefonica Alfa, InterSystems, Philips Research North America, and honoraria from Springer Nature publishing. EDAT- 2025/01/11 14:11 MHDA- 2025/04/04 06:26 PMCR- 2026/05/01 CRDT- 2025/01/11 06:23 PHST- 2024/12/11 00:00 [revised] PHST- 2024/11/12 00:00 [received] PHST- 2024/12/21 00:00 [accepted] PHST- 2025/04/04 06:26 [medline] PHST- 2025/01/11 14:11 [pubmed] PHST- 2025/01/11 06:23 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - 10.1002/ajmg.a.63980 [doi] PST - ppublish SO - Am J Med Genet A. 2025 May;197(5):e63980. doi: 10.1002/ajmg.a.63980. Epub 2025 Jan 11. PMID- 39797321 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250113 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 14 IP - 1 DP - 2025 Jan 3 TI - Bayesian Sequential Pragmatic Cluster Randomized Clinical Trial Design for PrEventive Effect of MEditerranean Diet in Children: PEMED Trial Research Protocol. LID - 10.3390/jcm14010240 [doi] LID - 240 AB - Background: Childhood nutrition plays an important role in the promotion of long-term health. Introducing solid foods in alignment with the Mediterranean Diet during weaning fosters a preference for healthy foods early in life. However, access to nutritious diets remains a challenge in underserved communities. Scampia, a socioeconomically disadvantaged district in Naples, Italy, exemplifies a community where barriers to healthy eating persist. This research reports a trial protocol that plans for a study to evaluate the impact of the Mediterranean Diet on child health and to establish preventive strategies for chronic diseases. Methods: The PEMED (PrEventive effect of MEditerranean Diet in Children) trial is a Bayesian Sequential Pragmatic Cluster Randomized Clinical Trial. Family Pediatricians (FPs) are randomized to deliver either Mediterranean Diet-based dietary guidance starting at weaning or standard dietary practices using typical baby foods. Children will be followed up for six years, with regular assessments of growth, microbiome composition, and adherence to the Mediterranean Diet, using validated tools. Interim analyses will be conducted at three-year intervals to evaluate the efficacy and monitor adverse events. Saliva and stool samples will be collected for genetic and microbiome analyses, and adherence will be monitored through quarterly dietary recalls and biomarkers. Results: This trial will consider Italy's established FP network for implementing innovative dietary intervention in a real-world setting. Conclusions: This study will address nutritional disparities in the underserved Scampia community and provide a scalable model for early dietary interventions. The results will shed light on the role of the Mediterranean Diet in improving childhood health and informing public health strategies globally. FAU - Azzolina, Danila AU - Azzolina D AUID- ORCID: 0000-0002-8185-5742 AD - Department of Preventive and Environmental Science, University of Ferrara, 44121 Ferrara, Italy. AD - Clinical Trial and Biostatistics, Research and Development Unit, University Hospital of Ferrara, 44121 Ferrara, Italy. FAU - Auricchio, Salvatore AU - Auricchio S AD - European Laboratory for Food Induced Diseases, University of Naples Federico II, 80131 Naples, Italy. FAU - Greco, Luigi AU - Greco L AD - European Laboratory for Food Induced Diseases, University of Naples Federico II, 80131 Naples, Italy. FAU - Auricchio, Renata AU - Auricchio R AD - European Laboratory for Food Induced Diseases, University of Naples Federico II, 80131 Naples, Italy. LA - eng PT - Journal Article DEP - 20250103 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC11721821 OTO - NOTNLM OT - bayesian OT - children OT - cluster-randomized OT - mediterranean diet OT - sequential trial COIS- The authors declare no conflicts of interest. EDAT- 2025/01/11 13:56 MHDA- 2025/01/11 13:57 PMCR- 2025/01/03 CRDT- 2025/01/11 01:15 PHST- 2024/11/05 00:00 [received] PHST- 2024/12/09 00:00 [revised] PHST- 2025/01/01 00:00 [accepted] PHST- 2025/01/11 13:57 [medline] PHST- 2025/01/11 13:56 [pubmed] PHST- 2025/01/11 01:15 [entrez] PHST- 2025/01/03 00:00 [pmc-release] AID - jcm14010240 [pii] AID - jcm-14-00240 [pii] AID - 10.3390/jcm14010240 [doi] PST - epublish SO - J Clin Med. 2025 Jan 3;14(1):240. doi: 10.3390/jcm14010240. PMID- 39796625 OWN - NLM STAT- MEDLINE DCOM- 20250430 LR - 20250521 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 1 DP - 2025 Jan 5 TI - The Prevalence of and Factors Associated with Disordered Eating Among Adult Athletes in Italy and Lebanon. LID - 10.3390/nu17010191 [doi] LID - 191 AB - BACKGROUND/OBJECTIVES: Disordered eating (DE) is a wide-spectrum condition, represented by altered eating patterns, behaviors, and attitudes aimed at controlling food intake, body weight, and shape, which does not necessarily satisfy the diagnostic criteria for an eating disorder of clinical severity. DE is frequently reported among athletes, but its prevalence and associated factors have not been fully elucidated. In this study, we intended to assess the prevalence of DE among adult athletes from different sports disciplines in Italy and Lebanon and to identify the factors associated with DE. METHODS: A validated questionnaire (Eating Attitude Test [EAT-26]) was administered to determine the prevalence of DE, which was indicated by a score >/= 17. Sport-related information, such as the type of sport, level of competition, training volume, and years of athletic experience, was also collected. RESULTS: Among the total sample of 881 athletes, 78 were identified as having DE, with a prevalence of 6.1% (7.8% of females and 4.9% of males) in Italian athletes and 21.3% (27.3% of females and 17.0% of males) in Lebanese athletes. In addition, among male athletes, the risk of having DE was more than threefold in those practicing weightlifting or bodybuilding (odds ratio [OR] = 3.23; 95% confidence interval [CI] = 1.03-10.08, and p < 0.05), while females with more athletic experience had almost 10% less risk of having DE (OR = 0.92; 95%CI = 0.86-0.98, and p < 0.05). CONCLUSIONS: DE is a prevalent condition among athletes. Therefore, it is crucial that sports federations and committees consider adopting standardized practical guidelines that focus on routinely screening for the early identification of DE in this population and implementing strategies for its timely management. In the future, longitudinal studies are also needed to clarify the impact of DE on athletes' clinical condition as well as their physical fitness and sports performance. FAU - Cavedon, Valentina AU - Cavedon V AUID- ORCID: 0000-0002-2464-1019 AD - Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy. FAU - Kreidieh, Dima AU - Kreidieh D AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Beirut Arab University, P.O. Box 11-5020 Riad El Solh, Beirut 11072809, Lebanon. FAU - Milanese, Chiara AU - Milanese C AUID- ORCID: 0000-0002-8011-4379 AD - Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy. FAU - Itani, Leila AU - Itani L AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Beirut Arab University, P.O. Box 11-5020 Riad El Solh, Beirut 11072809, Lebanon. FAU - Pellegrini, Massimo AU - Pellegrini M AUID- ORCID: 0000-0002-0091-0077 AD - Center for the Study of Metabolism, Body Composition and Lifestyle, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy. FAU - Saadeddine, Dana AU - Saadeddine D AUID- ORCID: 0009-0004-6344-0385 AD - Center for the Study of Metabolism, Body Composition and Lifestyle, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy. FAU - Berri, Elisa AU - Berri E AD - Degree Course of Dietetics, Innovation and Research Training Service, Azienda Ospedaliero-Universitaria di Modena, 41124 Modena, Italy. AD - Department of Primary Care, Azienda Unita Sanitaria Locale-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy. FAU - El Ghoch, Marwan AU - El Ghoch M AUID- ORCID: 0000-0003-4277-4752 AD - Center for the Study of Metabolism, Body Composition and Lifestyle, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy. LA - eng PT - Journal Article DEP - 20250105 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Lebanon/epidemiology MH - Female MH - Male MH - *Feeding and Eating Disorders/epidemiology MH - Prevalence MH - Adult MH - Italy/epidemiology MH - *Athletes/psychology/statistics & numerical data MH - Young Adult MH - Surveys and Questionnaires MH - Risk Factors MH - Feeding Behavior MH - Middle Aged MH - Adolescent PMC - PMC11723392 OTO - NOTNLM OT - dieting OT - eating disorders OT - overtraining OT - physical exercise OT - physical fitness and performance OT - sport competitions COIS- The authors declare no conflicts of interest. EDAT- 2025/01/11 14:01 MHDA- 2025/01/11 14:02 PMCR- 2025/01/05 CRDT- 2025/01/11 01:11 PHST- 2024/12/21 00:00 [received] PHST- 2024/12/30 00:00 [revised] PHST- 2025/01/04 00:00 [accepted] PHST- 2025/01/11 14:02 [medline] PHST- 2025/01/11 14:01 [pubmed] PHST- 2025/01/11 01:11 [entrez] PHST- 2025/01/05 00:00 [pmc-release] AID - nu17010191 [pii] AID - nutrients-17-00191 [pii] AID - 10.3390/nu17010191 [doi] PST - epublish SO - Nutrients. 2025 Jan 5;17(1):191. doi: 10.3390/nu17010191. PMID- 39796565 OWN - NLM STAT- MEDLINE DCOM- 20250111 LR - 20250606 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 1 DP - 2024 Dec 31 TI - Nutrient Intake and Dietary Adequacy Among Rural Tanzanian Infants Enrolled in the Mycotoxin Mitigation Trial. LID - 10.3390/nu17010131 [doi] LID - 131 AB - BACKGROUND: The Mycotoxin Mitigation Trial (MMT) was a community-based cluster-randomized trial designed to assess the effect of dietary aflatoxin (AF) on linear growth. Similar dietary intake between arms was an important component of the trial's program theory and essential for the trial's internal validity and interpretation. OBJECTIVE: This analysis assessed and compared dietary intake by arm within a sub-sample of infants enrolled in the MMT. METHODS: Twenty paired clusters (10 per trial arm) out of the 52 MMT clusters were included in this sub-sample. Up to 15 maternal/infant dyads per cluster were randomly selected for a one-time, structured, multi-pass 24 h dietary recall. Data were collected at the midpoint of the trial, when infants were 12 months of age, over 8 calendar months. We evaluated and compared infant nutrient intake and adequacy of energy, protein, lipid, iron, zinc, calcium, and vitamin A between study arms. Nutrient intake by arm was estimated using mixed-level regression models. RESULTS: A total of 282 mothers participated (n = 140 intervention arm and 142 standard of care (SoC) arm). The mean daily intakes of energy and lipid fed to infants were 505 kcal/day (SD = 225.9) and 13 g/day (SD = 6.9), respectively, in the intervention and SoC arms, with no difference between arms. Intervention infants consumed slightly more protein than SoC infants (13.7 v. 12.3 g/day, p = 0.02). Consumption of iron, zinc, calcium, and vitamin A were low and did not differ between arms. CONCLUSIONS: At the midpoint of the MMT, energy, lipid, and micronutrient intake did not differ between arms. Protein consumption was slightly greater in the intervention arm. Guided by the trial's program theory, this analysis advances the interpretation of the MMT trial findings. FAU - Kayanda, Rosemary A AU - Kayanda RA AD - Department of Food Sciences and Biotechnology, School of Life Sciences and Bioengineering, The Nelson Mandela African Institution of Science and Technology (NM-AIST), Arusha P.O. Box 447, Tanzania. FAU - Kassim, Neema AU - Kassim N AD - Department of Food Sciences and Biotechnology, School of Life Sciences and Bioengineering, The Nelson Mandela African Institution of Science and Technology (NM-AIST), Arusha P.O. Box 447, Tanzania. FAU - Ngure, Francis M AU - Ngure FM AD - Division of Nutritional Sciences, Cornell University, 244 Garden Ave, Ithaca, NY 14853, USA. FAU - Stoltzfus, Rebecca J AU - Stoltzfus RJ AD - Division of Nutritional Sciences, Cornell University, 244 Garden Ave, Ithaca, NY 14853, USA. AD - Office of the President, Goshen College, 1700 S Main St, Goshen, IN 46526, USA. FAU - Phillips, Erica AU - Phillips E AUID- ORCID: 0000-0001-6013-2863 AD - Division of Nutritional Sciences, Cornell University, 244 Garden Ave, Ithaca, NY 14853, USA. AD - Department of Nutritional Sciences, University of Wisconsin-Madison, 1415 Linden Dr, Madison, WI 53706, USA. LA - eng GR - OPP1155626/The Bill and Melinda Gates Foundation/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20241231 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Aflatoxins) RN - 0 (Mycotoxins) RN - 0 (Micronutrients) SB - IM MH - Humans MH - Infant MH - Female MH - *Rural Population MH - Male MH - Tanzania MH - *Diet MH - *Infant Nutritional Physiological Phenomena MH - Energy Intake MH - *Aflatoxins MH - Adult MH - *Mycotoxins MH - Nutritional Status MH - Micronutrients/administration & dosage PMC - PMC11722735 OTO - NOTNLM OT - 24 h dietary recalls OT - complementary feeding OT - nutrient intake COIS- The authors declare no conflicts of interest. EDAT- 2025/01/11 14:01 MHDA- 2025/01/11 14:02 PMCR- 2024/12/31 CRDT- 2025/01/11 01:11 PHST- 2024/11/18 00:00 [received] PHST- 2024/12/18 00:00 [revised] PHST- 2024/12/27 00:00 [accepted] PHST- 2025/01/11 14:02 [medline] PHST- 2025/01/11 14:01 [pubmed] PHST- 2025/01/11 01:11 [entrez] PHST- 2024/12/31 00:00 [pmc-release] AID - nu17010131 [pii] AID - nutrients-17-00131 [pii] AID - 10.3390/nu17010131 [doi] PST - epublish SO - Nutrients. 2024 Dec 31;17(1):131. doi: 10.3390/nu17010131. PMID- 39796523 OWN - NLM STAT- MEDLINE DCOM- 20250111 LR - 20250130 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 1 DP - 2024 Dec 29 TI - The Diet Quality of Athletes as Measured by Diet Quality Indices: A Scoping Review. LID - 10.3390/nu17010089 [doi] LID - 89 AB - BACKGROUND/OBJECTIVES: The goals of sports nutrition are to support athletic performance. However, the diet quality of athletes remains poorly understood. This scoping review aims to synthesise the existing body of literature, evaluating the diet quality of adult athletes. METHODS: The scoping review was conducted in accordance with guidance from the Joanna Briggs Institute. Database searches were conducted in Medline, Scopus, SPORTDiscus, Web of Science, and EMBASE. Eligible studies were observational, utilised a validated dietary quality assessment tool (diet quality index), and assessed athletes aged 18 to 65 years. Screening was performed independently by two researchers, with any conflicts resolved by a third researcher. RESULTS: The search yielded 1142 articles, of which 18 met the inclusion criteria. Basketball athletes and gymnasts were the most frequently examined groups. Studies were dominated by one gender (n = 7 all males studies, n = 4 only female). Eleven diet quality tools were used, including variations of the Healthy Eating Index (n = 7). Overall diet quality was rated as poor (n = 3 studies), needs improvement (n = 12), or adequate (n = 3). Food groups where intake was suboptimal included wholegrains (n = 8), fruit (n = 5), and dairy intake (n = 3). The intake of protein-rich foods was adequate in n = 9 studies, whilst fat intake was excessive in 4 studies. CONCLUSIONS: These findings suggested that the diet quality of athletes is suboptimal and needs improvement in the areas of wholegrain, fruit, and dairy/alternatives intake. The inadequate intake of these food groups and the consumption of excessive fat intake may increase the long-term risk of developing non-communicable diseases and impair short-term performance and recovery. Further exploration is warranted to develop targeted nutrition education and interventions that address these inadequacies. FAU - Dion, Stella AU - Dion S AUID- ORCID: 0009-0007-0008-3132 AD - School of Medical, Indigenous and Health Sciences, Faculty of Science Medicine and Health, University of Wollongong, Wollongong, NSW 2500, Australia. FAU - Walker, Gabriel AU - Walker G AD - School of Medical, Indigenous and Health Sciences, Faculty of Science Medicine and Health, University of Wollongong, Wollongong, NSW 2500, Australia. FAU - Lambert, Kelly AU - Lambert K AUID- ORCID: 0000-0001-5935-7328 AD - School of Medical, Indigenous and Health Sciences, Faculty of Science Medicine and Health, University of Wollongong, Wollongong, NSW 2500, Australia. FAU - Stefoska-Needham, Anita AU - Stefoska-Needham A AUID- ORCID: 0000-0001-7114-1634 AD - School of Medical, Indigenous and Health Sciences, Faculty of Science Medicine and Health, University of Wollongong, Wollongong, NSW 2500, Australia. FAU - Craddock, Joel C AU - Craddock JC AUID- ORCID: 0000-0002-5290-3952 AD - School of Medical, Indigenous and Health Sciences, Faculty of Science Medicine and Health, University of Wollongong, Wollongong, NSW 2500, Australia. LA - eng PT - Journal Article PT - Scoping Review DEP - 20241229 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Athletes MH - Male MH - *Diet/standards MH - Female MH - Adult MH - Adolescent MH - Diet, Healthy MH - Young Adult MH - Sports Nutritional Physiological Phenomena MH - Middle Aged MH - Athletic Performance MH - Aged MH - Nutrition Assessment PMC - PMC11722857 OTO - NOTNLM OT - athlete OT - diet quality OT - diet quality index OT - nutrition OT - scoping review OT - sports COIS- The authors declare no conflicts of interest. EDAT- 2025/01/11 14:04 MHDA- 2025/01/11 14:05 PMCR- 2024/12/29 CRDT- 2025/01/11 01:10 PHST- 2024/12/10 00:00 [received] PHST- 2024/12/23 00:00 [revised] PHST- 2024/12/27 00:00 [accepted] PHST- 2025/01/11 14:05 [medline] PHST- 2025/01/11 14:04 [pubmed] PHST- 2025/01/11 01:10 [entrez] PHST- 2024/12/29 00:00 [pmc-release] AID - nu17010089 [pii] AID - nutrients-17-00089 [pii] AID - 10.3390/nu17010089 [doi] PST - epublish SO - Nutrients. 2024 Dec 29;17(1):89. doi: 10.3390/nu17010089. PMID- 39794197 OWN - NLM STAT- MEDLINE DCOM- 20250122 LR - 20250521 IS - 2341-2879 (Electronic) IS - 2341-2879 (Linking) VI - 102 IP - 1 DP - 2025 Jan TI - Design and validation of a questionnaire on habits, health and exercise in the use of baby carriers. PG - 503717 LID - S2341-2879(24)00322-3 [pii] LID - 10.1016/j.anpede.2024.503717 [doi] AB - INTRODUCTION: Understanding the characteristics and implications of the use of baby carriers can help health care providers understand the habits of their patients and provide guidance to improve quality of life in both children and caregivers. The aim of our study was to design and validate the first self-administered questionnaire to assess babywearing habits and their impact on health and physical activity as a means to monitor musculoskeletal complaints in caregivers. MATERIAL AND METHODS: 350 individuals who currently used or had used baby carrying systems in the last 10 years completed the questionnaire, which was previously subject to a pilot study in a panel of experts. We used exploratory factor analysis to assess the validity of the internal structure of the questionnaire. The Cronbach alpha coefficient was used to assess reliability. We used varimax rotation to improve the interpretation of the extracted factors. RESULTS: The factor analysis showed that the questionnaire is appropriate for measuring the dimensions or carriage factors established a priori. It extracted 3 factors each for the constructs of duration and weight of carriage, motivation, exercise habits and effects on infant health and 2 factors for caregiver pain that explained between 55% and 72% of the variance in each construct. The Cronbach alpha values were greater than 0.5. CONCLUSIONS: The results support the validity of the questionnaire and demonstrate that it is useful for its intended purpose. CI - Copyright (c) 2024 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L.U. All rights reserved. FAU - Taboada-Iglesias, Yaiza AU - Taboada-Iglesias Y AD - Departamento de Didacticas Especiales, Facultad de Ciencias de la Educacion y el Deporte, Universidad de Vigo, Vigo, Pontevedra, Spain; Grupo de Investigacion en Educacion, Actividad Fisica y Salud (Gies10-DE3), Instituto de Investigacion Sanitaria Galicia Sur (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Pontevedra, Spain. Electronic address: yaitaboada@uvigo.gal. FAU - Iglesias-Perez, Maria Del Carmen AU - Iglesias-Perez MDC AD - Departamento de Estadistica e Investigacion Operativa, Escuela de Ingenieria Forestal, Universidad de Vigo, Vigo, Pontevedra, Spain; Grupo de Investigacion Inferencia Estadistica, Decision e Investigacion Operativa, Universidad de Vigo, Vigo, Pontevedra, Spain. FAU - Gutierrez-Sanchez, Agueda AU - Gutierrez-Sanchez A AD - Departamento de Didacticas Especiales, Facultad de Ciencias de la Educacion y el Deporte, Universidad de Vigo, Vigo, Pontevedra, Spain; Grupo de Investigacion en Educacion, Actividad Fisica y Salud (Gies10-DE3), Instituto de Investigacion Sanitaria Galicia Sur (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Pontevedra, Spain. LA - eng PT - Journal Article PT - Validation Study DEP - 20250109 PL - Spain TA - An Pediatr (Engl Ed) JT - Anales de pediatria JID - 101765626 SB - IM MH - Humans MH - Male MH - Female MH - *Exercise MH - Infant MH - Adult MH - Reproducibility of Results MH - Surveys and Questionnaires MH - *Caregivers MH - *Habits MH - Self Report MH - Middle Aged OTO - NOTNLM OT - Bebe OT - Cuestionario OT - Ejercicio OT - Exercise OT - Habits OT - Habitos OT - Infant OT - Infant carrying OT - Paediatrics OT - Pediatria OT - Physical health OT - Porteo OT - Salud fisica OT - Surveys OT - Validez OT - Validity COIS- Declaration of competing interest The authors have no conflicts of interest to declare. EDAT- 2025/01/11 13:57 MHDA- 2025/01/23 05:15 CRDT- 2025/01/10 21:55 PHST- 2024/07/04 00:00 [received] PHST- 2024/10/21 00:00 [accepted] PHST- 2025/01/23 05:15 [medline] PHST- 2025/01/11 13:57 [pubmed] PHST- 2025/01/10 21:55 [entrez] AID - S2341-2879(24)00322-3 [pii] AID - 10.1016/j.anpede.2024.503717 [doi] PST - ppublish SO - An Pediatr (Engl Ed). 2025 Jan;102(1):503717. doi: 10.1016/j.anpede.2024.503717. Epub 2025 Jan 9. PMID- 39790039 OWN - NLM STAT- MEDLINE DCOM- 20250430 LR - 20260812 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 28 IP - 1 DP - 2025 Jan 10 TI - Developing and using a School Menu Healthiness Assessment Tool to analyse school food provision in Wales. PG - 36 LID - 10.1017/S1368980025000047 [doi] LID - e36 AB - OBJECTIVES: To design and develop a new, innovative and valid School Menu Healthiness Assessment Tool that is suitable for the quantitative and qualitative analysis of school food and drink provision. Second, to analyse primary and secondary school menus and price lists pan-Wales to ascertain their healthiness and whether free school meal (FSM) eligible pupils can afford to access healthy, nutritious food across the school day. DESIGN: Codable items and categories of school food and drink provision were operationalised before the tool underwent iterative development and testing. Then, cross-sectional content analysis of publicly available documents detailing school food provision (i.e. menus and price lists) was done. SETTING: Primary and secondary schools in Wales, UK. PARTICIPANTS: In total, 82 canteen menus were sourced online. This comprised local authority catering for primary (n 22) and secondary (n 19) schools and school-organised catering for primary (n 5) and secondary (n 36) schools. RESULTS: Intercoder reliability testing found high agreeability between coders, demonstrating that the tool and data interpretation are reproducible and trustworthy. The FSM allowance is not wholly sufficient for all secondary school pupils to purchase a healthy meal from the school canteen. Moreover, the tool identified that oily fish and wholegrain provision were lacking across many menus. CONCLUSIONS: A valuable tool was created, useful for researchers and other health professionals (i.e. dietitians) who are required to analyse the healthiness of school food provision in line with the latest nutritional requirements. This study provides insight into the current school food and drink landscape pan-Wales. FAU - Gilmour, Alice AU - Gilmour A AUID- ORCID: 0000-0002-7602-9083 AD - School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK. FAU - Fairchild, Ruth AU - Fairchild R AUID- ORCID: 0000-0001-5251-7827 AD - School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250110 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Wales MH - *Schools MH - *Food Services/economics MH - Cross-Sectional Studies MH - *Diet, Healthy/economics MH - Child MH - Adolescent MH - Reproducibility of Results MH - Nutritive Value MH - Students PMC - PMC11822622 OTO - NOTNLM OT - Diet quality OT - Instrument OT - Nutrition assessment OT - School food standards COIS- There is no conflict of interest. EDAT- 2025/01/10 06:19 MHDA- 2025/02/07 11:12 PMCR- 2025/01/10 CRDT- 2025/01/10 04:03 PHST- 2025/02/07 11:12 [medline] PHST- 2025/01/10 06:19 [pubmed] PHST- 2025/01/10 04:03 [entrez] PHST- 2025/01/10 00:00 [pmc-release] AID - S1368980025000047 [pii] AID - 10.1017/S1368980025000047 [doi] PST - epublish SO - Public Health Nutr. 2025 Jan 10;28(1):36. doi: 10.1017/S1368980025000047. PMID- 39789792 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260901 IS - 1475-2662 (Electronic) IS - 0007-1145 (Print) IS - 0007-1145 (Linking) VI - 133 IP - 3 DP - 2025 Feb 14 TI - Effects of plant-based diet on metabolic parameters, liver and kidney steatosis: a prospective interventional open-label study. PG - 289-298 LID - 10.1017/S0007114525000017 [doi] AB - This interventional single-centre prospective open-label study aims to evaluate the effects of a vegan diet, compared with a vegetarian and omnivorous diet, on metabolic parameters, insulin sensitivity, and liver and kidney steatosis in healthy adults. The study included fifty-three omnivorous participants aged 18-40 years, BMI 18-30 kg/m(2), without any chronic disease, chronic medication use, active smoking or significant alcohol consumption. All participants were omnivorous at baseline and selected to continue an omnivorous diet or transition to a vegetarian or vegan diet, with follow-up over 6 months. Anthropometric measurements, biochemical parameters and liver and kidney steatosis were assessed at baseline and after six months using MRI-proton density fat fraction. Primary outcomes included changes in liver and kidney steatosis, while secondary outcomes were alterations in anthropometric and biochemical markers. Among fifty-three participants, eighteen followed an omnivorous diet, twenty-one adopted a vegetarian diet and fourteen transitioned to a vegan diet. Dietary interventions did not result in statistically significant changes in BMI, fat mass, fat percentage or muscle mass over 6 months. However, statistically significant improvements in systolic and diastolic blood pressure, favouring the vegan diet, were observed. We aimed to control for potentially confounding variables to ensure the reliability of these findings. We have demonstrated a better decline in steatosis at the lower kidney pole, the total hilus and the Liver 6 index in vegans. We demonstrated that a plant-based diet is associated with improvements in several metabolic parameters and may reduce liver and kidney steatosis. FAU - Guler Senturk, Begum AU - Guler Senturk B AD - Department of Internal Medicine, Koc University School of Medicine, Istanbul, Turkey. FAU - Gurses, Bengi AU - Gurses B AD - Department of Radiology, Koc University School of Medicine, Istanbul, Turkey. FAU - Soyturk, Ceren AU - Soyturk C AD - Clinical Dietician, Koc University Hospital, Istanbul, Turkey. FAU - Copur, Sidar AU - Copur S AD - Department of Internal Medicine, Koc University School of Medicine, Istanbul, Turkey. FAU - Incir, Said AU - Incir S AD - Department of Clinical Biochemistry, Koc University School of Medicine, Istanbul, Turkey. FAU - Siriopol, Dimitrie AU - Siriopol D AD - Department of Nephrology, 'Saint John the New' County Hospital, Suceava, Romania. FAU - Hasbal, Nuri Baris AU - Hasbal NB AUID- ORCID: 0000-0002-2229-5140 AD - Division of Nephrology, Department of Internal Medicine, Koc University School of Medicine, Istanbul, Turkey. FAU - Akyildiz, Murat AU - Akyildiz M AD - Division of Gastroenterology, Department of Internal Medicine, Koc University School of Medicine, Istanbul, Turkey. FAU - van Raalte, Daniel H AU - van Raalte DH AD - Diabetes Center, Department of Internal Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands. FAU - Kanbay, Mehmet AU - Kanbay M AUID- ORCID: 0000-0002-1297-0675 AD - Division of Nephrology, Department of Internal Medicine, Koc University School of Medicine, Istanbul, Turkey. LA - eng SI - ClinicalTrials.gov/NCT05351853 PT - Journal Article DEP - 20250110 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM MH - Humans MH - Female MH - Prospective Studies MH - Adult MH - Male MH - Young Adult MH - *Diet, Vegetarian MH - *Diet, Vegan MH - *Fatty Liver/diet therapy MH - Adolescent MH - *Kidney/pathology MH - Liver/metabolism MH - Insulin Resistance MH - Body Mass Index PMC - PMC11946044 OTO - NOTNLM OT - Chronic kidney disease OT - Hepatosteatosis OT - Non-alcoholic fatty liver disease OT - Steatosis OT - Vegetarian diet EDAT- 2025/01/10 06:19 MHDA- 2026/07/30 12:42 PMCR- 2025/03/27 CRDT- 2025/01/10 01:33 PHST- 2026/07/30 12:42 [medline] PHST- 2025/01/10 06:19 [pubmed] PHST- 2025/01/10 01:33 [entrez] PHST- 2025/03/27 00:00 [pmc-release] AID - S0007114525000017 [pii] AID - 10.1017/S0007114525000017 [doi] PST - ppublish SO - Br J Nutr. 2025 Feb 14;133(3):289-298. doi: 10.1017/S0007114525000017. Epub 2025 Jan 10. PMID- 39787191 OWN - NLM STAT- MEDLINE DCOM- 20250109 LR - 20260921 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 1 DP - 2025 TI - Predicting early cessation of exclusive breastfeeding using machine learning techniques. PG - e0312238 LID - 10.1371/journal.pone.0312238 [doi] LID - e0312238 AB - BACKGROUND: Identification of mother-infant pairs predisposed to early cessation of exclusive breastfeeding is important for delivering targeted support. Machine learning techniques enable development of transparent prediction models that enhance clinical applicability. We aimed to develop and validate two models to predict cessation of exclusive breastfeeding within one month among infants born after 35 weeks gestation using machine learning techniques. METHODS: Utilizing a nationwide dataset from Statistics Denmark, including infants born between the 1st of January 2014 and the 31st of December 2015, we employed random forest machine learning to develop two predictive models. The first model included 11 well-established factors associated with cessation of exclusive breastfeeding within one month. The second model was expanded to include 21 additional factors associated with complications during pregnancy and delivery that potentially impede breastfeeding. Feature importance was applied to elucidate the factors driving model predictions. RESULTS: The dataset comprised 110,206 infants and 106,835 mothers. The first model predicted cessation of exclusive breastfeeding within one month with an area under the receiver operating curve of 62.0% (95% confidence interval 61.3% - 62.7%) and an accuracy of 60.4% (95% confidence interval 59.8% - 61.0%). The second model predicted cessation of exclusive breastfeeding within one month with an area under the receiver operating curve of 62.2% (95% confidence interval 61.5% - 62.9%) and an accuracy of 60.0% (95% confidence interval 59.3% - 60.6%). In both models, birthplace, maternal education, delivery mode, and maternal body mass index were the most important factors influencing the overall model performance. CONCLUSIONS: The two models could not accurately predict cessation of exclusive breastfeeding within one month among infants born after 35 weeks gestation. Contrary to our expectations, including additional factors in the model did not increase model performance. CI - Copyright: (c) 2025 Nejsum et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Nejsum, Freja Marie AU - Nejsum FM AUID- ORCID: 0000-0003-2142-4542 AD - Department of Pediatrics, Copenhagen University Hospital-North Zealand, Hillerod, Denmark. FAU - Wiingreen, Rikke AU - Wiingreen R AUID- ORCID: 0000-0002-6794-436X AD - Department of Pediatrics, Copenhagen University Hospital-North Zealand, Hillerod, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. FAU - Jensen, Andreas Kryger AU - Jensen AK AD - Department of Public Health, University of Copenhagen, Copenhagen, Denmark. AD - Department of Clinical Research, Copenhagen University Hospital-North Zealand, Hillerod, Denmark. FAU - Lokkegaard, Ellen Christine Leth AU - Lokkegaard ECL AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. AD - Department of Gynaecology and Obstetrics, Copenhagen University Hospital-North Zealand, Hillerod, Denmark. FAU - Molholm Hansen, Bo AU - Molholm Hansen B AD - Department of Pediatrics, Copenhagen University Hospital-North Zealand, Hillerod, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250109 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Breast Feeding MH - *Machine Learning MH - Female MH - Adult MH - Infant, Newborn MH - Pregnancy MH - Denmark MH - Mothers MH - Male MH - Infant MH - ROC Curve PMC - PMC11717195 COIS- The authors have declared that no competing interests exist. EDAT- 2025/01/09 18:22 MHDA- 2025/01/09 18:23 PMCR- 2025/01/09 CRDT- 2025/01/09 13:54 PHST- 2024/04/28 00:00 [received] PHST- 2024/10/04 00:00 [accepted] PHST- 2025/01/09 18:23 [medline] PHST- 2025/01/09 18:22 [pubmed] PHST- 2025/01/09 13:54 [entrez] PHST- 2025/01/09 00:00 [pmc-release] AID - PONE-D-24-15143 [pii] AID - 10.1371/journal.pone.0312238 [doi] PST - epublish SO - PLoS One. 2025 Jan 9;20(1):e0312238. doi: 10.1371/journal.pone.0312238. eCollection 2025. PMID- 39786679 OWN - NLM STAT- MEDLINE DCOM- 20250128 LR - 20250520 IS - 1434-9949 (Electronic) IS - 0770-3198 (Print) IS - 0770-3198 (Linking) VI - 44 IP - 2 DP - 2025 Feb TI - Reliability and validity of the Londrina activities of daily living protocol in individuals with systemic sclerosis. PG - 719-726 LID - 10.1007/s10067-025-07309-y [doi] AB - PURPOSE: To investigate the validity and reliability of the Londrina ADL Protocol in patients with systemic sclerosis (SSc). METHODS: The study included 39 individuals with SSc and 30 healthy participants aged 18-70 years. Performance-related ADL assessment was performed with the Londrina ADL Protocol which was performed twice by the same rater and energy expenditure during the test with the Dynaport Move Monitor device. Functional capacity (6 Minute Walk Test-6MWT), upper extremity muscle strength (hand-held dynamometer), hand and finger grip strength (hand dynamometer and pinch meter), upper extremity functionality (Q-Dash Questionnaire and 9 Hole Peg Test), self-reported ADL (Milliken ADL Scale (MAS)) and quality of life (SF-36 questionnaire) were evaluated. RESULTS: Upper extremity muscle strength, functional capacity, upper extremity functionality, and quality of life of individuals with SSc were found to be significantly lower and the time spent by individuals with SSc in the Londrina ADL Protocol was lower and the time spent by individuals with SSc in the Londrina ADL Protocol was significantly longer compared to the healthy group (p<0.05). Performance in the the Londrina ADL had high intraclass correlation coefficient ICC=0.813. A moderate negative correlation was found between the time to complete the Londrina Protocol and 6MWT (p<0.05), and a weak negative correlation was found between dominant side hand grip strength (p<0.05) and MAS (p<0.05) in individuals with SSc. A moderate positive correlation was found between the Londrina Protocol and the 9-Hole Peg Test for the dominant side (p<0.05). CONCLUSION: The Londrina Protocol is a valid and reliable method, hence, this makes it appropriate for an objective, performance-based evaluation of ADL in SSc population. Key Points * The results obtained by reapplication the Londrina ADL Protocol under the same conditions showed that the Londrina ADL Protocol is a highly reliable assessment method in scleroderma patients. * Considering the activities and protocol content of the Londrina ADL Protocol, it is thought to show functional performance better than the Glittre ADL test and 6MWT. * The Londrina ADL Protocol is appropriate for objective and performance-based assessment of ADL in the SSc population for both research and clinical practice. CI - (c) 2025. The Author(s). FAU - Gedikli, Yasemin AU - Gedikli Y AUID- ORCID: 0009-0006-3652-9194 AD - Faculty of Physical Therapy and Rehabilitation, Department of Physiotherapy and Rehabilitation, Dokuz Eylul University, Izmir, Turkey. yasemingedikli.291@gmail.com. AD - Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Selcuk University, Konya, Turkey. yasemingedikli.291@gmail.com. FAU - Ozcan Kahraman, Buse AU - Ozcan Kahraman B AD - Faculty of Physical Therapy and Rehabilitation, Cardiopulmonary Department, Dokuz Eylul University, Izmir, Turkey. FAU - Birlik, Merih AU - Birlik M AD - Department of Internal Disease, Division of Immunology and Rheumatology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey. FAU - Acar, Serap AU - Acar S AD - Faculty of Physical Therapy and Rehabilitation, Cardiopulmonary Department, Dokuz Eylul University, Izmir, Turkey. FAU - Savci, Sema AU - Savci S AD - Faculty of Physical Therapy and Rehabilitation, Cardiopulmonary Department, Dokuz Eylul University, Izmir, Turkey. AD - Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey. LA - eng PT - Journal Article PT - Validation Study DEP - 20250109 PL - Germany TA - Clin Rheumatol JT - Clinical rheumatology JID - 8211469 SB - IM MH - Humans MH - Middle Aged MH - Adult MH - Male MH - Female MH - *Scleroderma, Systemic/physiopathology MH - *Activities of Daily Living MH - Quality of Life MH - Aged MH - Hand Strength/physiology MH - Reproducibility of Results MH - Young Adult MH - Adolescent MH - Upper Extremity/physiopathology MH - Muscle Strength/physiology MH - Walk Test MH - Disability Evaluation PMC - PMC11775064 OTO - NOTNLM OT - Systemic sclerosis OT - activities of daily living OT - functional capacity OT - upper extremity muscle strength COIS- Declarations. Ethics approval and consent to participate: The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved. All patients gave written informed consent. Noninvasive Research Ethics Board of Dokuz Eylul University approved this study (Approval number: 2023/22-04). Conflict of interest: The authors declare that they have no conflict of interest. EDAT- 2025/01/09 16:59 MHDA- 2025/01/28 18:21 PMCR- 2025/01/09 CRDT- 2025/01/09 11:20 PHST- 2024/11/13 00:00 [received] PHST- 2024/12/30 00:00 [accepted] PHST- 2024/12/21 00:00 [revised] PHST- 2025/01/28 18:21 [medline] PHST- 2025/01/09 16:59 [pubmed] PHST- 2025/01/09 11:20 [entrez] PHST- 2025/01/09 00:00 [pmc-release] AID - 10.1007/s10067-025-07309-y [pii] AID - 7309 [pii] AID - 10.1007/s10067-025-07309-y [doi] PST - ppublish SO - Clin Rheumatol. 2025 Feb;44(2):719-726. doi: 10.1007/s10067-025-07309-y. Epub 2025 Jan 9. PMID- 39785110 OWN - NLM STAT- MEDLINE DCOM- 20250526 LR - 20250822 IS - 1445-2197 (Electronic) IS - 1445-1433 (Print) IS - 1445-1433 (Linking) VI - 95 IP - 5 DP - 2025 May TI - Metabolic bariatric surgery generates substantial, sustained weight loss and health improvement in a real-world setting. PG - 895-903 LID - 10.1111/ans.19378 [doi] AB - BACKGROUND: To determine if the positive outcomes from clinical trials regarding the safety and efficacy of metabolic bariatric surgery are reproducible at a national level. METHODS: A longitudinal registry-based observation study with data collected from all persons undergoing metabolic bariatric surgery in Australia from 28 February 2012-31 December 2021 including data from 122,567 index patients who underwent 134,625 completed bariatric procedures. MAIN OUTCOMES AND MEASURES: Defined adverse outcomes at 90-days (unplanned readmission, intensive care admission and re-operation; death), annual change in weight (percent total body weight loss (TBWL)), diabetes treatment and need for re-operation. RESULTS: 79.0% of participants were female. Mean age on the day of surgery was 44.0 years (SD 11.8; range 12.9-87.9 years) and mean BMI 41.7 kg/m2 (SD 7.6). At 5-years participants who underwent one anastomosis gastric bypass had TBWL 34.88% (SD 8.67%), roux-en-Y gastric bypass 30.73 % (SD 9.47%); sleeve gastrectomy 26.5% (SD 10.5%) and adjustable gastric bands 17.6% (SD 12.1%). At 90-days 3.6% of procedures recorded a defined adverse event. 13,904 (13.6%) primary participants reported being treated for diabetes at baseline. No medication for diabetes was required by 71.6% (follow-up 58%) at 1-year and 61% (follow-up 22%) at 5-years. 13 904 (13.6%) primary participants reported being treated for diabetes at baseline. No medication for diabetes was required by 71.6% (follow-up 58%) at 1-year and 61% (follow-up 22%) at 5-years. CONCLUSIONS: Metabolic bariatric surgery is safe and induces substantial weight loss with reduced need for diabetes medications in the real-world. GOV ID: NCT03441451. CI - (c) 2025 The Author(s). ANZ Journal of Surgery published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Surgeons. FAU - Brown, Wendy A AU - Brown WA AUID- ORCID: 0000-0002-0137-2688 AD - Bariatric Surgery Registry, Central Clinical School, Monash University, Melbourne, Victoria, Australia. AD - Monash University Department of Surgery, Central Clinical School, Alfred Health, Melbourne, Victoria, Australia. AD - Oesophago-Gastric and Bariatric Unit, Alfred Health, Melbourne, Victoria, Australia. FAU - Brown, Dianne L AU - Brown DL AD - Bariatric Surgery Registry, Central Clinical School, Monash University, Melbourne, Victoria, Australia. FAU - Holland, Jennifer F AU - Holland JF AD - Bariatric Surgery Registry, Central Clinical School, Monash University, Melbourne, Victoria, Australia. FAU - Campbell, Angus AU - Campbell A AD - Bariatric Surgery Registry, Central Clinical School, Monash University, Melbourne, Victoria, Australia. FAU - Cottrell, Jenifer AU - Cottrell J AD - Bariatric Surgery Registry, Central Clinical School, Monash University, Melbourne, Victoria, Australia. FAU - Ahern, Susannah AU - Ahern S AUID- ORCID: 0000-0001-9413-6897 AD - Bariatric Surgery Registry, Central Clinical School, Monash University, Melbourne, Victoria, Australia. AD - School of Public Health, Monash University, Melbourne, Victoria, Australia. FAU - Reilly, Jennifer AU - Reilly J AUID- ORCID: 0000-0002-7109-8493 AD - Department of Anaesthesiology and Perioperative Medicine, Monash University, Melbourne, Victoria, Australia. FAU - Garduce, Patrick AU - Garduce P AD - Bariatric Surgery Registry, Central Clinical School, Monash University, Melbourne, Victoria, Australia. AD - School of Public Health, Monash University, Melbourne, Victoria, Australia. FAU - Wetter, James AU - Wetter J AD - Bariatric Surgery Registry, Central Clinical School, Monash University, Melbourne, Victoria, Australia. FAU - Hamdorf, Jeffrey M AU - Hamdorf JM AD - Bariatric Surgery Registry, Central Clinical School, Monash University, Melbourne, Victoria, Australia. AD - Discipline of Surgery, Medical School, The University of Western Australia, Perth, Western Australia, Australia. FAU - Talbot, Michael AU - Talbot M AD - Bariatric Surgery Registry, Central Clinical School, Monash University, Melbourne, Victoria, Australia. AD - Department of Surgery, University of New South Wales St George and Sutherland Clinical School, Sydney, New South Wales, Australia. FAU - Baker, Samuel AU - Baker S AD - Bariatric Surgery Registry, Central Clinical School, Monash University, Melbourne, Victoria, Australia. AD - Department of Surgery, Mater Private Hospital, Townsville, Queensland, Australia. FAU - MacCormick, Andrew D AU - MacCormick AD AD - Bariatric Surgery Registry, Central Clinical School, Monash University, Melbourne, Victoria, Australia. AD - Department of Surgery, University of Auckland, Auckland, New Zealand. FAU - Caterson, Ian D AU - Caterson ID AD - Bariatric Surgery Registry, Central Clinical School, Monash University, Melbourne, Victoria, Australia. AD - Boden Initiative, Charles Perkins Centre, University of Sydney, New South Wales, Australia. LA - eng SI - ClinicalTrials.gov/NCT03441451 GR - Australian Government/ GR - Applied Medical/ GR - Johnson and Johnson/ GR - Avant Foundation/ GR - Apollo/ GR - Medtronic Foundation/ GR - W. L. Gore and Associates/ PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20250109 PL - Australia TA - ANZ J Surg JT - ANZ journal of surgery JID - 101086634 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Child MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - Australia/epidemiology MH - *Bariatric Surgery/methods MH - Body Mass Index MH - Longitudinal Studies MH - *Obesity, Morbid/surgery MH - Registries MH - Treatment Outcome MH - *Weight Loss/physiology PMC - PMC12105569 OTO - NOTNLM OT - metabolic bariatric surgery OT - outcomes OT - quality and safety OT - registry OT - weight loss COIS- Wendy A. Brown: Grants from Johnson and Johnson, Medtronic, GORE, Applied Medical, Novo Nordisk, NHMRC, Myerton and the Australian Government. Personal fees from GORE, Novo Nordisc, Pfizer, Medtronic and Merck Sharpe and Dohme for lectures and advisory boards. Professor Brown is an Editorial Board member of ANZ Journal of Surgery and a co-author of this article. To minimize bias, they were excluded from all editorial decision-making related to the acceptance of this article for publication. Jeffrey M. Hamdorf: Grants from Gore, Baxter Healthcare, Department of Health, Government of Western Australia, National Blood Authority Australia. Personal fees from Johnson and Johnson, Gore. Board Member, Australian and New Zealand Metabolic Obesity Surgery Society. Michael Talbot: Grants from Gore and Medtronic. Personal fees from Medtronic, Johnson and Johnson, Gore, Device Technologies, MSD, Green Surgical. Ian D. Caterson: Grants for clinical trials from Eli Lilly, Boehringer Ingelheim, Sydney Local Health District. Board member of Obesity Australia. Dianne L. Brown, Jennifer F. Holland, Angus Campbell, Jenifer Cottrell, Susannah Ahern, Jennifer Reilly, Patrick Garduce, James Wetter, Samuel Baker and Andrew D. MacCormick have no disclosures. EDAT- 2025/01/09 16:59 MHDA- 2025/05/26 12:37 PMCR- 2025/05/26 CRDT- 2025/01/09 09:13 PHST- 2024/11/29 00:00 [revised] PHST- 2024/11/03 00:00 [received] PHST- 2024/12/08 00:00 [accepted] PHST- 2025/05/26 12:37 [medline] PHST- 2025/01/09 16:59 [pubmed] PHST- 2025/01/09 09:13 [entrez] PHST- 2025/05/26 00:00 [pmc-release] AID - ANS19378 [pii] AID - 10.1111/ans.19378 [doi] PST - ppublish SO - ANZ J Surg. 2025 May;95(5):895-903. doi: 10.1111/ans.19378. Epub 2025 Jan 9. PMID- 39780347 OWN - NLM STAT- MEDLINE DCOM- 20250515 LR - 20260905 IS - 1530-0315 (Electronic) IS - 0195-9131 (Print) IS - 0195-9131 (Linking) VI - 57 IP - 6 DP - 2025 Jun 1 TI - Validity and Reliability of the Tampa Scale for Kinesiophobia for Adolescents with Heart Disease. PG - 1246-1256 LID - 10.1249/MSS.0000000000003642 [doi] AB - PURPOSE: To assess the validity and reliability of a newly adapted Tampa Scale for KP for adolescents with HD (TSK-Heart-A). METHODS: The TSK-Heart-A survey consists of 17 Likert scale items, producing a summary score (SS) ranging from 17 (low KP) to 68 (high KP). Following content and face validity, adolescents (age 12-18 yr) with arrhythmia disorders or Fontan palliation were recruited. The PROMIS pediatric anxiety and depression short forms, Pediatric Quality of Life Inventory (PedsQL) generic core and cardiac module, and a PA questionnaire for adolescents (PAQ-A) were used for criterion validity. The TSK-Heart-A was completed twice (20.4 +/- 6.3 days apart) for assessment of internal and test-retest reliability. Pearson correlations and Cronbach's alpha determined validity and reliability, respectively. RESULTS: Adolescents ( n = 63) were 15.5 +/- 1.8 yrs old, 50.8% were female, and 69.8% had arrhythmia disorder. Mean TSK-Heart-A SS was 33.8 +/- 7.8 (range, 20 to 56). The TSK-Heart-A SS correlated significantly with PROMIS T-scores (anxiety: 49.7 +/- 12.2, r = 0.48; depression: 46.9 +/- 12.7, r = 0.41), PedsQL score (generic QoL: 75.2 +/- 18.9, r = -0.61; cardiac QoL: 74.7 +/- 17.5, r = -0.56), and PAQ-A (score: 2.0 +/- 0.7, r = -0.35). Test-retest and internal reliability had a total score of r = 0.77 ( P = 0.89). CONCLUSIONS: The new TSK-Heart-A survey is valid and reliable and suggests that KP is present in some adolescents with HD. CI - Copyright (c) 2025 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Sports Medicine. FAU - White, David A AU - White DA AUID- ORCID: 0000-0002-4320-5351 FAU - Black, William R AU - Black WR AD - Center for Biobehavioral Health, Nationwide Children's Hospital, Columbus, OH. FAU - Cramer, Emily AU - Cramer E FAU - Malloy-Walton, Lindsey AU - Malloy-Walton L FAU - Walton, Mollie AU - Walton M AD - Ward Family Heart Center, Children's Mercy Kansas City, Kansas City, MO. FAU - Martis, Laura AU - Martis L AD - Ward Family Heart Center, Children's Mercy Kansas City, Kansas City, MO. FAU - Enneking, Brandy AU - Enneking B AD - Ward Family Heart Center, Children's Mercy Kansas City, Kansas City, MO. FAU - Teson, Kelli M AU - Teson KM FAU - Watson, Jessica S AU - Watson JS AD - Ward Family Heart Center, Children's Mercy Kansas City, Kansas City, MO. FAU - Gross-Toalson, Jami AU - Gross-Toalson J LA - eng GR - K23 HL159325/HL/NHLBI NIH HHS/United States GR - T32 HD069038/HD/NICHD NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Validation Study DEP - 20250109 PL - United States TA - Med Sci Sports Exerc JT - Medicine and science in sports and exercise JID - 8005433 SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - Reproducibility of Results MH - Child MH - Surveys and Questionnaires MH - Quality of Life MH - *Phobic Disorders/diagnosis/psychology MH - *Heart Diseases/psychology MH - Arrhythmias, Cardiac/psychology MH - Fontan Procedure/psychology MH - Kinesiophobia PMC - PMC13063351 MID - NIHMS2078154 OTO - NOTNLM OT - ARRHYTHMIA OT - FEAR OT - FONTAN OT - MENTAL HEALTH OT - PEDIATRIC OT - PHYSICAL ACTIVITY EDAT- 2025/01/09 06:22 MHDA- 2025/05/15 06:33 PMCR- 2026/04/09 CRDT- 2025/01/09 00:42 PHST- 2025/05/15 06:33 [medline] PHST- 2025/01/09 06:22 [pubmed] PHST- 2025/01/09 00:42 [entrez] PHST- 2026/04/09 00:00 [pmc-release] AID - 00005768-990000000-00701 [pii] AID - 10.1249/MSS.0000000000003642 [doi] PST - ppublish SO - Med Sci Sports Exerc. 2025 Jun 1;57(6):1246-1256. doi: 10.1249/MSS.0000000000003642. Epub 2025 Jan 9. PMID- 39780292 OWN - NLM STAT- MEDLINE DCOM- 20250109 LR - 20260127 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 13 IP - 1 DP - 2025 Jan 8 TI - Sports experience, affects and life satisfaction in Portuguese athletes with disabilities. PG - 19 LID - 10.1186/s40359-024-02247-x [doi] LID - 19 AB - This study aims to validate the Portuguese version of the Satisfaction with Life Scale (Cronbach's alpha = 0.82) and the Positive and Negative Affect Scale (Cronbach's alpha = 0.86 for positive affect and 0.89 for negative affect) for people with disabilities and to examine the association between engaging in physical activity and affective responses, investigating the relationship with satisfaction with life. 143 Portuguese with disabilities filled in the Portuguese version of the scales. The findings endorsed the single factorial structure and reliability of the Satisfaction with Life Scale [chi2/df = 6.3, B-S p = 0.487, TLI = 0.989, CFI = 0.995, SRMR = 0.0263, RMSEA = 0.043 (CI = 0, 0.130)]. For Positive and Negative Affect Scale, the results also confirmed the factorial structure and reliability [chi2/df = 1.871, B-S p = 0.114, TLI = 0.891, CFI = 0.918, SRMR = 0.0778, RMSEA = 0.078 (CI = 0.048, 0.108)]. On the other hand, the structural model presented satisfactory fit to the data [chi2/df = 1.436, B-S p = 0.269, TLI = 0.917, CFI = 0.930, SRMR = 0.0748, RMSEA = 0.055 (CI = 0.033, 0.075)]. Significant direct effects have been found, as has been theoretically proposed, namely: years of practice displayed a positive and significant association with positive affect; positive affect was positively associated with satisfaction with life (beta = 0.073, CI = 0.020, 0.139; p = 0.031). CI - (c) 2024. The Author(s). FAU - Jacinto, Miguel AU - Jacinto M AD - ESECS, Polytechnique of Leiria, 2411-901 Leiria, Portugal. miguel.s.jacinto@ipleiria.pt. AD - Research Center in Sport, Health, and Human Development (CIDESD), 5000-558 Vila Real, Portugal. miguel.s.jacinto@ipleiria.pt. FAU - Couto, Nuno AU - Couto N AD - Research Center in Sport, Health, and Human Development (CIDESD), 5000-558 Vila Real, Portugal. AD - Sport Sciences School of Rio Maior, Santarem Polytechnic University (ESDRM-IPSantarem), 2040-413 Rio Maior, Portugal. FAU - Vitorino, Anabela AU - Vitorino A AD - Research Center in Sport, Health, and Human Development (CIDESD), 5000-558 Vila Real, Portugal. AD - Sport Sciences School of Rio Maior, Santarem Polytechnic University (ESDRM-IPSantarem), 2040-413 Rio Maior, Portugal. FAU - Bento, Teresa AU - Bento T AD - Research Center in Sport, Health, and Human Development (CIDESD), 5000-558 Vila Real, Portugal. AD - Sport Sciences School of Rio Maior, Santarem Polytechnic University (ESDRM-IPSantarem), 2040-413 Rio Maior, Portugal. FAU - Matos, Rui AU - Matos R AD - ESECS, Polytechnique of Leiria, 2411-901 Leiria, Portugal. AD - Research Center in Sport, Health, and Human Development (CIDESD), 5000-558 Vila Real, Portugal. FAU - Monteiro, Diogo AU - Monteiro D AD - ESECS, Polytechnique of Leiria, 2411-901 Leiria, Portugal. AD - Research Center in Sport, Health, and Human Development (CIDESD), 5000-558 Vila Real, Portugal. FAU - Amaro, Nuno AU - Amaro N AD - ESECS, Polytechnique of Leiria, 2411-901 Leiria, Portugal. AD - Research Center in Sport, Health, and Human Development (CIDESD), 5000-558 Vila Real, Portugal. FAU - Antunes, Raul AU - Antunes R AD - ESECS, Polytechnique of Leiria, 2411-901 Leiria, Portugal. AD - Research Center in Sport, Health, and Human Development (CIDESD), 5000-558 Vila Real, Portugal. FAU - Cid, Luis AU - Cid L AD - Research Center in Sport, Health, and Human Development (CIDESD), 5000-558 Vila Real, Portugal. AD - Sport Sciences School of Rio Maior, Santarem Polytechnic University (ESDRM-IPSantarem), 2040-413 Rio Maior, Portugal. LA - eng GR - https://doi.org/10.54499/UIDB/04045/2020/Fundacao para a Ciencia e a Tecnologia/ GR - https://doi.org/10.54499/UIDB/04045/2020/Fundacao para a Ciencia e a Tecnologia/ GR - https://doi.org/10.54499/UIDB/04045/2020/Fundacao para a Ciencia e a Tecnologia/ GR - https://doi.org/10.54499/UIDB/04045/2020/Fundacao para a Ciencia e a Tecnologia/ GR - https://doi.org/10.54499/UIDB/04045/2020/Fundacao para a Ciencia e a Tecnologia/ GR - https://doi.org/10.54499/UIDB/04045/2020/Fundacao para a Ciencia e a Tecnologia/ GR - https://doi.org/10.54499/UIDB/04045/2020/Fundacao para a Ciencia e a Tecnologia/ GR - https://doi.org/10.54499/UIDB/04045/2020/Fundacao para a Ciencia e a Tecnologia/ GR - https://doi.org/10.54499/UIDB/04045/2020/Fundacao para a Ciencia e a Tecnologia/ PT - Journal Article DEP - 20250108 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - *Personal Satisfaction MH - Portugal MH - Male MH - Female MH - Adult MH - *Persons with Disabilities/psychology MH - *Athletes/psychology/statistics & numerical data MH - Affect MH - Middle Aged MH - Young Adult MH - Sports/psychology MH - Reproducibility of Results MH - Adolescent MH - Surveys and Questionnaires MH - Psychometrics/instrumentation PMC - PMC11708300 OTO - NOTNLM OT - Affect OT - Disability OT - Psychometric properties OT - Satisfaction OT - Validity COIS- Declarations. Ethics approval and consent to participate: Data collection adhered to the principles outlined in the Helsinki Declaration. The study was approved by an ethics committee of the University of Beira Interior under the code CE-UBI-Pj-2018-076. Informed consent was obtained from all subjects involved in the study. Written informed consent has been obtained from the patient(s) to publish this paper. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/01/09 06:22 MHDA- 2025/01/09 06:23 PMCR- 2025/01/08 CRDT- 2025/01/09 00:04 PHST- 2024/07/05 00:00 [received] PHST- 2024/12/02 00:00 [accepted] PHST- 2025/01/09 06:23 [medline] PHST- 2025/01/09 06:22 [pubmed] PHST- 2025/01/09 00:04 [entrez] PHST- 2025/01/08 00:00 [pmc-release] AID - 10.1186/s40359-024-02247-x [pii] AID - 2247 [pii] AID - 10.1186/s40359-024-02247-x [doi] PST - epublish SO - BMC Psychol. 2025 Jan 8;13(1):19. doi: 10.1186/s40359-024-02247-x. PMID- 39779357 OWN - NLM STAT- MEDLINE DCOM- 20250108 LR - 20250111 IS - 1658-3175 (Electronic) IS - 0379-5284 (Print) IS - 0379-5284 (Linking) VI - 46 IP - 1 DP - 2025 Jan TI - Body shape concerns, sexual satisfaction, and associated factors among patients with polycystic ovarian syndrome: A cross-sectional study in Western Saudi Arabia. PG - 94-101 LID - 10.15537/smj.2025.46.1.20240797 [doi] AB - OBJECTIVES: To determine body shape concerns (BSCs), sexual satisfaction, and associated factors in patients with polycystic ovarian syndrome (PCOS). METHODS: Using a structured and validated questionnaire, a cross-sectional survey was carried out at the Maternity and Children's Hospital in Makkah, Saudi Arabia. Data were collected between August 2023 and June 2024. We included adult patients with PCOS who had completed at least one follow-up visit. We used multivariate analysis to determine the factors associated with BSC and sexual function. Spearman's correlation analysis was executed to assess the correlation concerning these 2 aspects. RESULTS: Of the 432 patients studied, nearly half (50.9%) had some degree of BSC and sexual dysfunction (50.5%). Body shape concern exhibited a significant association with age (p=0.001), education (p=0.017), occupation (p=0.005), and follow-up status (p=0.005). Sexual function and satisfaction were significantly associated with education (p=0.001), body mass index (p=0.001), and the existence of other comorbidities (p=0.011). Additionally, the study revealed a negative relationship between sexual function assessment and BSC (Spearman's rho= -0.567; p=0.001). CONCLUSION: This study encourages healthcare providers to proactively query sexual apprehension among these patients. These findings may guide health caregivers, policymakers, and scholars in developing measures to improve the quality of life of women with PCOS. CI - Copyright: (c) Saudi Medical Journal. FAU - Alsaidan, Aseel A AU - Alsaidan AA AUID- ORCID: 0000-0003-0220-6160 AD - From the Department of Family and Community Medicine (Alsaidan, Thirunavukkarasu), College of Medicine, Jouf University, Aljouf; and from the Department of Public Health (Alsulami), Maternity and Children Hospital, Makkah, Kingdom of Saudi Arabia. FAU - Thirunavukkarasu, Ashokkumar AU - Thirunavukkarasu A AD - From the Department of Family and Community Medicine (Alsaidan, Thirunavukkarasu), College of Medicine, Jouf University, Aljouf; and from the Department of Public Health (Alsulami), Maternity and Children Hospital, Makkah, Kingdom of Saudi Arabia. FAU - Alsulami, Hani H AU - Alsulami HH AD - From the Department of Family and Community Medicine (Alsaidan, Thirunavukkarasu), College of Medicine, Jouf University, Aljouf; and from the Department of Public Health (Alsulami), Maternity and Children Hospital, Makkah, Kingdom of Saudi Arabia. LA - eng PT - Journal Article PL - Saudi Arabia TA - Saudi Med J JT - Saudi medical journal JID - 7909441 SB - IM MH - Humans MH - Female MH - Saudi Arabia/epidemiology MH - *Polycystic Ovary Syndrome/psychology/complications/epidemiology MH - Cross-Sectional Studies MH - Adult MH - Young Adult MH - *Body Image/psychology MH - Body Mass Index MH - Surveys and Questionnaires MH - Personal Satisfaction MH - Educational Status MH - Orgasm MH - Age Factors MH - Sexual Behavior MH - Sexual Dysfunction, Physiological/epidemiology/etiology PMC - PMC11717095 OTO - NOTNLM OT - Makkah OT - Saudi Arabia OT - body shape concerns OT - sexual dysfunction OT - women EDAT- 2025/01/09 00:22 MHDA- 2025/01/09 00:23 PMCR- 2025/01/01 CRDT- 2025/01/08 21:53 PHST- 2024/09/12 00:00 [received] PHST- 2024/12/08 00:00 [accepted] PHST- 2025/01/09 00:23 [medline] PHST- 2025/01/09 00:22 [pubmed] PHST- 2025/01/08 21:53 [entrez] PHST- 2025/01/01 00:00 [pmc-release] AID - 46/1/94 [pii] AID - SaudiMedJ-46-1-94 [pii] AID - 10.15537/smj.2025.46.1.20240797 [doi] PST - ppublish SO - Saudi Med J. 2025 Jan;46(1):94-101. doi: 10.15537/smj.2025.46.1.20240797. PMID- 39779113 OWN - NLM STAT- MEDLINE DCOM- 20250108 LR - 20260519 IS - 1873-7145 (Electronic) IS - 0963-9969 (Linking) VI - 200 DP - 2025 Jan TI - Adolescents as food designers: The value of co-creation for the development of healthy dairy products. PG - 115455 LID - S0963-9969(24)01525-4 [pii] LID - 10.1016/j.foodres.2024.115455 [doi] AB - Healthy eating habits may protect adolescents against disease development, ensure optimal physical and cognitive development, and may persist in adulthood. However, adolescents usually prefer sweetened dairy products and show a low consumption of vegetables, fruits, whole grains, and pulses. Co-creation offers an innovative and inclusive alternative for the development of new products. Adolescents' involvement in the co-creation process may promote the development of healthy products that they can effectively choose. This study aimed to use the co-creation process through exploring, prototyping, refining, and validation stages for developing healthy dairy products with and for adolescents, aiming to obtain comprehensive insights into theiropinions, perceptions, preferences, and needs. Twenty-eight adolescents (14-18 years old) participated in three co-creation sections, while the other 65 (14-18 years old) participated only in the validation stage. The adolescents created a healthy dairy product using a set of ingredients in the first section (grouped into dairy base, fruits, vegetables, nuts and grains, and culinary ingredients). The adolescents could select the ingredients in the number and quantity they wanted for developing the product. There were only two rules: the dairy base was limited to one, and at least one ingredient of each group must be used. Four factors drove the ingredient selection (hedonic, sensory properties, health impact, and novelty). Afterward, they tasted their prototype and noted possible improvements. In the second section, they created a concept prototype (post) as a product communication strategy. They were requested to create a post similar to those shared on social media to promote their product and invite other adolescents to try it. Seven factors drove the post design (product name, poster visual design, promotional image, ingredients, sensory properties, health compounds and health claims, and marketing purposes). The third section validated the refined products (products with the improvements suggested during the tasting stage) and posts for acceptance and perceptions. The products were accepted by adolescents involved or not in the co-creation process despite using healthy and novel ingredients and sugar reduction. Furthermore, based on the posts, the products were perceived as healthy, nutritious, tasty, and with suitable texture. The concentration of vegetables, grains, and nuts was lower than the fruits, demonstrating that, although the adolescents accepted the products, they would not be the central ingredient. The adolescents participating in the co-creation sections were not biased towards higher acceptance scores or more positive perceptions of the posts than general adolescents. These results demonstrated the high potential to involve adolescents in product co-creation and provide helpful subsidies for its implementation. The healthy dairy products co-created in this study could comply with policy measures designed to reduce added sugar intake and increase the intake of fruits and vegetables. Public health policies may encourage schools to engage adolescents in cooking activities and meal planning, besides performing marketing restrictions and food reformulation strategies, mainly related to sugar reduction. CI - Copyright (c) 2024 Elsevier Ltd. All rights reserved. FAU - Pinesso Ribeiro, Ana Cristina AU - Pinesso Ribeiro AC AD - State University of Londrina (UEL), Londrina, Brazil. FAU - Barao, Carlos Eduardo AU - Barao CE AD - Federal Institute of Parana (IFPR), Campus Paranavai, Paranavai, Parana, Brazil. FAU - Tavares Filho, Elson Rogerio AU - Tavares Filho ER AD - Fluminense Federal University (UFF), Niteroi, Rio de Janeiro, Brazil; Federal Institute of Education, Science, and Technology of Rio de Janeiro, Departamento of Food, Rio de Janeiro, Brazil. FAU - Esmerino, Erick Almeida AU - Esmerino EA AD - Fluminense Federal University (UFF), Niteroi, Rio de Janeiro, Brazil. FAU - Silva, Ramon AU - Silva R AD - Fluminense Federal University (UFF), Niteroi, Rio de Janeiro, Brazil; Federal Institute of Education, Science, and Technology of Rio de Janeiro, Departamento of Food, Rio de Janeiro, Brazil. FAU - Cruz, Adriano Gomes AU - Cruz AG AD - Federal Institute of Education, Science, and Technology of Rio de Janeiro, Departamento of Food, Rio de Janeiro, Brazil. FAU - Pimentel, Tatiana Colombo AU - Pimentel TC AD - State University of Londrina (UEL), Londrina, Brazil; Federal Institute of Parana (IFPR), Campus Paranavai, Paranavai, Parana, Brazil. Electronic address: tatiana.pimentel@ifpr.edu.br. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241129 PL - Canada TA - Food Res Int JT - Food research international (Ottawa, Ont.) JID - 9210143 SB - IM MH - Adolescent MH - Humans MH - *Dairy Products MH - Female MH - Male MH - *Food Preferences MH - *Diet, Healthy MH - Consumer Behavior MH - Vegetables MH - Fruit OTO - NOTNLM OT - Co-creation OT - Co-designing OT - Dairy derivatives OT - New product development OT - Open innovation COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/01/09 00:22 MHDA- 2025/01/09 00:23 CRDT- 2025/01/08 21:01 PHST- 2024/08/13 00:00 [received] PHST- 2024/10/29 00:00 [revised] PHST- 2024/11/26 00:00 [accepted] PHST- 2025/01/09 00:23 [medline] PHST- 2025/01/09 00:22 [pubmed] PHST- 2025/01/08 21:01 [entrez] AID - S0963-9969(24)01525-4 [pii] AID - 10.1016/j.foodres.2024.115455 [doi] PST - ppublish SO - Food Res Int. 2025 Jan;200:115455. doi: 10.1016/j.foodres.2024.115455. Epub 2024 Nov 29. PMID- 39777358 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250108 IS - 1664-042X (Print) IS - 1664-042X (Electronic) IS - 1664-042X (Linking) VI - 15 DP - 2024 TI - Effects of exercise on bone mass and bone metabolism in adolescents: a systematic review and meta-analysis. PG - 1512822 LID - 10.3389/fphys.2024.1512822 [doi] LID - 1512822 AB - OBJECTIVE: Meta-analysis was used to evaluate the effects of an exercise intervention on bone mineral content (BMC), bone mineral density (BMD), and bone metabolism in adolescents. METHODS: A systematic search of PubMed, Embase, Cochrane Library, and Web of Science for RCTs on "exercise, adolescents, BMD, bone metabolism" up to 10 September 2024. Included RCTs focused on effects of exercise on BMC, BMD, and bone metabolism in 10-19 years old, with physical activity as exercise group and daily living/primal exercise as control group. Outcome metrics included lumbar spine, femoral neck, whole body BMC and BMD, bone alkaline phosphatase (BALP), procollagen type 1N-terminal propeptide (PINP), osteocalcin (OC), and type I collagen carboxy-terminal peptide (CTX). Exclusion criteria included duplicates, non-RCTs, non-adolescent studies, and non-compliance with indicators. Meta-analyses were performed using RevMan 5.4, and quality assessed by Cochrane's tool. Effect sizes were estimated using standardized mean differences (SMDs) and 95% confidence intervals (CIs), and heterogeneity was assessed using the I (2) statistic to determine fixed or random effects models. RESULTS: Fifteen articles with a total of 723 subjects were included. The meta-analysis showed that, compared to the control group, (i) exercise was effective in increasing adolescents' overall BMC (SMD = 0.16, 95% CI: 0.06-0.27, p = 0.003) and BMD (SMD = 0.26, 95% CI: 0.13-0.40, p = 0.0001). (ii) Subgroup analyses showed that exercise significantly increased adolescents' lumbar spine BMC (SMD = 0.17, 95% CI: 0.01-0.34, p = 0.04), femoral neck BMC (SMD = 0.23, 95% CI: 0.05-0.42, p = 0.01), lumbar spine BMD (SMD = 0.34, 95% CI: 0.12-0.56, p = 0.003) and femoral neck BMD (SMD = 0.31, 95% CI: 0.09-0.53, p = 0.007), whereas there was no statistically significant effect on whole body BMC and BMD (p > 0.05). (iii) Exercise increased BALP, and decreased PINP, OC and CTX in adolescents. but none of the differences between the exercise groups and the control group were significant (p > 0.05). CONCLUSION: Exercise is effective in improving overall BMC and BMD in adolescents and elevating BMC and BMD of the lumbar spine and femoral neck. Due to the limitation of the number and quality of the included studies, the above conclusions are yet to be validated by more high-quality empirical studies. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/, identifier CRD42024593399. CI - Copyright (c) 2024 Zhang, Wang, Liu, He, Ding, Mei and Li. FAU - Zhang, Wenhua AU - Zhang W AD - School of Graduate Education, Shandong Sport University, Jinan, Shandong, China. FAU - Wang, Xiaoqiang AU - Wang X AD - School of Sport and Health, Shandong Sport University, Jinan, Shandong, China. FAU - Liu, Yurong AU - Liu Y AD - Department of Basic Medicine, College of Medicine, Hunan Normal University, Changsha, Hunan, China. FAU - He, Qiang AU - He Q AD - School of Physical Education, Shandong University, Jinan, Shandong, China. FAU - Ding, Qixin AU - Ding Q AD - School of Rehabilitation, Henan University of Chinese Medicine, Zhengzhou, Henan, China. FAU - Mei, Jingqi AU - Mei J AD - Department of Nursing, College of Medicine, Hunan Normal University, Changsha, Hunan, China. FAU - Li, Xun AU - Li X AD - School of Sport and Health, Shandong Sport University, Jinan, Shandong, China. LA - eng PT - Journal Article PT - Systematic Review DEP - 20241224 PL - Switzerland TA - Front Physiol JT - Frontiers in physiology JID - 101549006 PMC - PMC11703972 OTO - NOTNLM OT - adolescents OT - bone metabolism OT - bone mineral content OT - bone mineral density OT - exercise OT - meta-analysis OT - physical activity OT - randomized controlled trial COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/01/09 00:22 MHDA- 2025/01/09 00:23 PMCR- 2024/12/24 CRDT- 2025/01/08 18:06 PHST- 2024/10/17 00:00 [received] PHST- 2024/12/11 00:00 [accepted] PHST- 2025/01/09 00:23 [medline] PHST- 2025/01/09 00:22 [pubmed] PHST- 2025/01/08 18:06 [entrez] PHST- 2024/12/24 00:00 [pmc-release] AID - 1512822 [pii] AID - 10.3389/fphys.2024.1512822 [doi] PST - epublish SO - Front Physiol. 2024 Dec 24;15:1512822. doi: 10.3389/fphys.2024.1512822. eCollection 2024. PMID- 39776520 OWN - NLM STAT- MEDLINE DCOM- 20250108 LR - 20250905 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 13 DP - 2024 TI - Association between diet quality during pregnancy of mothers and that of 3-year-old offspring: a prospective hospital-based birth cohort study. PG - e26 LID - 10.1017/jns.2024.24 [doi] LID - e26 AB - Children's eating habits are established early in life and parents play a major role therein. Pregnancy is a teachable moment for the promotion of healthy eating because many women are concerned about their babies' health and have frequent contact with healthcare providers. We aimed to investigate the association between diet quality during pregnancy and the offspring. A total of 691 sets of data on pregnant mothers and their 3-year-old offspring were obtained from the Seiiku Boshi cohort study. Dietary intake was assessed using a validated food frequency questionnaire for mothers in mid-to-late pregnancy and a validated diet history questionnaire for Japanese preschool children at the 36-month checkup. Diet quality was scored using the Japanese Food Guide Spinning Top. Maternal diet quality score was categorised into quartiles, and the association between offspring and maternal diet quality score, adjusted for socioeconomic factors, was assessed using multiple linear regression. The total offspring diet quality score showed a linear trend with the maternal diet quality score (the mean increments (confidential intervals) for each quartile were -0.12 (-1.32-1.08), 1.54 (0.34-2.73), and 1.22 (0.03-2.42)). In particular, offspring vegetable dishes scored higher in all quartiles of maternal vegetable dish scores than in the lowest quartile (0.69 (0.21-1.17), 0.97 (0.50-1.45), and 1.36 (0.88-1.83)). A high diet quality score during pregnancy was positively associated with that of offspring, suggesting the importance of nutritional education in pregnant women to improve their diet quality. CI - (c) The Author(s) 2024. FAU - Tada, Yuki AU - Tada Y AUID- ORCID: 0000-0003-1292-6110 AD - Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo, Japan. AD - Department of Social Medicine, National Center for Child Health and Development, Tokyo, Japan. FAU - Ishitsuka, Kazue AU - Ishitsuka K AUID- ORCID: 0000-0002-2944-7012 AD - Department of Social Medicine, National Center for Child Health and Development, Tokyo, Japan. FAU - Piedvache, Aurelie AU - Piedvache A AD - Department of Social Medicine, National Center for Child Health and Development, Tokyo, Japan. FAU - Tanaka, Hisako AU - Tanaka H AD - Department of Social Medicine, National Center for Child Health and Development, Tokyo, Japan. FAU - Ogawa, Kohei AU - Ogawa K AD - Department of Social Medicine, National Center for Child Health and Development, Tokyo, Japan. AD - Center of Maternal-fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan. FAU - Kobayashi, Minatsu AU - Kobayashi M AD - Department of Social Medicine, National Center for Child Health and Development, Tokyo, Japan. AD - Department of Food Science, Otsuma Women's University, Tokyo, Japan. FAU - Horikawa, Reiko AU - Horikawa R AD - Division of Endocrinology and Metabolism, National Center for Child Health and Development, Tokyo, Japan. FAU - Fujiwara, Takeo AU - Fujiwara T AD - Department of Social Medicine, National Center for Child Health and Development, Tokyo, Japan. AD - Department of Public Health, Tokyo Medical and Dental University, Tokyo, Japan. FAU - Morisaki, Naho AU - Morisaki N AUID- ORCID: 0000-0001-6151-4513 AD - Department of Social Medicine, National Center for Child Health and Development, Tokyo, Japan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240802 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Child, Preschool MH - Prospective Studies MH - *Diet MH - Adult MH - Male MH - *Mothers MH - Japan MH - Birth Cohort MH - Feeding Behavior MH - Maternal Nutritional Physiological Phenomena MH - Surveys and Questionnaires MH - Vegetables MH - Socioeconomic Factors MH - Cohort Studies PMC - PMC11704931 OTO - NOTNLM OT - Birth cohort OT - Diet quality OT - Japan OT - Pregnant women OT - Preschool children COIS- The authors declare none. EDAT- 2025/01/08 18:22 MHDA- 2025/01/09 00:21 PMCR- 2024/01/01 CRDT- 2025/01/08 17:53 PHST- 2023/10/16 00:00 [received] PHST- 2024/03/01 00:00 [revised] PHST- 2024/03/21 00:00 [accepted] PHST- 2025/01/09 00:21 [medline] PHST- 2025/01/08 18:22 [pubmed] PHST- 2025/01/08 17:53 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - S2048679024000247 [pii] AID - 10.1017/jns.2024.24 [doi] PST - epublish SO - J Nutr Sci. 2024 Aug 2;13:e26. doi: 10.1017/jns.2024.24. eCollection 2024. PMID- 39775523 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250111 IS - 2767-3375 (Electronic) IS - 2767-3375 (Linking) VI - 5 IP - 1 DP - 2025 TI - Food habit, physical activity and nutritional status of adolescents in selected schools of Madhyapur Thimi municipality, Nepal: A cross-sectional study. PG - e0004136 LID - 10.1371/journal.pgph.0004136 [doi] LID - e0004136 AB - A dramatic rise in obesity is caused by unhealthy eating habits combined with lower levels of physical activity, and the under nutrition problem is still unresolved. Focusing on the nutritional needs of adolescents could be a significant step toward breaking the vicious cycle of malnutrition, chronic diseases, and poverty. This study aims to assess food habit, levels of physical activity and nutritional status of adolescents in Madhyapur Thimi Municipality, Bhaktapur. A cross-sectional descriptive study design was conducted. Cluster random sampling technique with validated, self-administered questionnaire was used for data collection. Ethical approval, written informed consent and assent were obtained. International Physical Activity Questionnaire (IPAQ) was used to measure level of physical activity. Nutritional Status was measured in terms of BMI for age z-score. Height and weight were measured by using UNICEF Stadiometer and Seca Scale. Data were analyzed using Chi-square test and logistic regression analysis was applied for the further analysis using SPSS V 20. Among the 460 participants, 19.6% were overweight, while 8.5% were underweight. Factors showing a statistical association with being overweight included the mother's occupation, fruit avoidance, exposure to mass media advertisements, junk food consumption. Almost all the participants (93%) consumed junk food with (57.5%) consuming daily or alternately. Regarding physical activity, 65.4% of participants engaged in moderate activity, 30.7% were inactive and only 3.9% engaged in high levels of physical activity. The level of physical activity did not show a significant association with being overweight. Public health nutritionists should actively engage adolescents in developing interventions that promote healthy eating habits and reduce junk food consumption, as adolescents are more susceptible to food marketing than adults. Physical activity alone may not be responsible for being overweight as dietary modification plays vital role in maintaining normal body weight. CI - Copyright: (c) 2025 Baral et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Baral, Samiksha AU - Baral S AUID- ORCID: 0009-0008-9455-4704 AD - Central Department of Public Health, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal. FAU - Singh, Anil Kumar AU - Singh AK AUID- ORCID: 0009-0002-9400-3140 AD - Central Department of Public Health, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal. FAU - Aryal, Arjun AU - Aryal A AD - Central Department of Public Health, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal. FAU - Subedi, Jwala AU - Subedi J AD - School of Public Health and Community Medicine, B. P. Koirala Institute of Health Sciences, Dharan, Nepal. FAU - Dhakal, Utsav AU - Dhakal U AD - GoldenGate International, Tribhuvan University, Kathmandu, Nepal. FAU - Khanal, Anita AU - Khanal A AUID- ORCID: 0009-0005-6117-1465 AD - Central Department of Public Health, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal. LA - eng PT - Journal Article DEP - 20250107 PL - United States TA - PLOS Glob Public Health JT - PLOS global public health JID - 9918283779606676 PMC - PMC11706376 COIS- The authors have declared that no competing interests exist. EDAT- 2025/01/08 18:22 MHDA- 2025/01/08 18:23 PMCR- 2025/01/07 CRDT- 2025/01/08 17:03 PHST- 2024/08/10 00:00 [received] PHST- 2024/12/16 00:00 [accepted] PHST- 2025/01/08 18:23 [medline] PHST- 2025/01/08 18:22 [pubmed] PHST- 2025/01/08 17:03 [entrez] PHST- 2025/01/07 00:00 [pmc-release] AID - PGPH-D-24-01811 [pii] AID - 10.1371/journal.pgph.0004136 [doi] PST - epublish SO - PLOS Glob Public Health. 2025 Jan 7;5(1):e0004136. doi: 10.1371/journal.pgph.0004136. eCollection 2025. PMID- 39771024 OWN - NLM STAT- MEDLINE DCOM- 20250108 LR - 20250108 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 24 DP - 2024 Dec 22 TI - Validity of a Short Food Frequency Questionnaire for Toddlers of NELA Birth Cohort Study. LID - 10.3390/nu16244403 [doi] LID - 4403 AB - BACKGROUND/OBJECTIVES: Our aim was to evaluate the reproducibility and validity of a semi-quantitative food frequency questionnaire (FFQ) for the assessment of usual nutrient and food intakes in children of 18 months old. METHODS: We included 103 toddlers aged 18 months from the Nutrition in Early Life and Asthma (NELA) birth cohort study. A 47-item FFQ was administered twice to parents with a 3-month interval. During that period, we also performed three non-consecutive 24 h dietary recalls (24hDRs) and oral mucosa samples for determining the fatty acid profile (glycerophospholipids). We estimated correlation coefficients of reproducibility for nutrient and food group intakes by comparing both FFQs and validity coefficients by comparing nutrient intakes between the second FFQ and the average of the three 24hDRs. We also explored biochemical validity by comparing the intake of fish from the FFQ with the percentage of fatty acids in oral mucosa cells. RESULTS: The average of correlation coefficients for FFQ reproducibility was r = 0.48 for energy-adjusted nutrient intakes (ranging from r = 0.28 for Na to r = 0.62 for Mg and Zn) and r = 0.35 for the intake of energy-adjusted food groups. The average correlation coefficient for FFQ validity on nutrient intakes was r = 0.48, ranging from r = 0.16 for alpha-carotene to r = 0.75 for vitamin E. We also found a positive correlation between total omega-3 fatty acids and docosahexaenoic acid percentages in oral mucosa cells and the intake of total and white fish, r = 0.31 and r = 0.34, respectively. CONCLUSIONS: This study shows that our short FFQ demonstrated moderate reproducibility (mean r = 0.48) and validity (mean r = 0.48) for dietary assessment of most nutrients and foods in 18-month-old children in Spain. This FFQ provides an efficient and minimally invasive method for evaluating toddler dietary intake, particularly in Mediterranean contexts. FAU - Gonzalez-Palacios, Sandra AU - Gonzalez-Palacios S AUID- ORCID: 0000-0003-3358-472X AD - Unidad de Epidemiologia de la Nutricion (EPINUT), Departamento de SaludPublica, Historia de la Ciencia y Ginecologia, Universidad Miguel Hernandez (UMH), 03550 Alicante, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), 03010 Alicante, Spain. AD - Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain. FAU - Ojeda-Belokon, Carolina AU - Ojeda-Belokon C AUID- ORCID: 0000-0002-3392-1354 AD - Unidad de Epidemiologia de la Nutricion (EPINUT), Departamento de SaludPublica, Historia de la Ciencia y Ginecologia, Universidad Miguel Hernandez (UMH), 03550 Alicante, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), 03010 Alicante, Spain. AD - Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain. FAU - Oncina-Canovas, Alejandro AU - Oncina-Canovas A AUID- ORCID: 0000-0003-4652-0565 AD - Unidad de Epidemiologia de la Nutricion (EPINUT), Departamento de SaludPublica, Historia de la Ciencia y Ginecologia, Universidad Miguel Hernandez (UMH), 03550 Alicante, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), 03010 Alicante, Spain. AD - Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain. FAU - Compan-Gabucio, Laura-Maria AU - Compan-Gabucio LM AUID- ORCID: 0000-0001-5324-1535 AD - Unidad de Epidemiologia de la Nutricion (EPINUT), Departamento de SaludPublica, Historia de la Ciencia y Ginecologia, Universidad Miguel Hernandez (UMH), 03550 Alicante, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), 03010 Alicante, Spain. AD - Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain. FAU - Pastor-Fajardo, Maria-Teresa AU - Pastor-Fajardo MT AD - Department of Pediatrics, Hospital General Universitario de Elche, Elche, 03203 Alicante, Spain. AD - Biomedical Research Institute of Murcia (IMIB-Arrixaca), 30120 Murcia, Spain. FAU - Perez, Adrian AU - Perez A AD - Departament of Fisiology, University of Murcia, 30100 Murcia, Spain. FAU - Gazquez, Antonio AU - Gazquez A AUID- ORCID: 0000-0001-5023-7442 AD - Biomedical Research Institute of Murcia (IMIB-Arrixaca), 30120 Murcia, Spain. AD - Departament of Fisiology, University of Murcia, 30100 Murcia, Spain. FAU - Larque, Elvira AU - Larque E AUID- ORCID: 0000-0001-6805-3449 AD - Biomedical Research Institute of Murcia (IMIB-Arrixaca), 30120 Murcia, Spain. AD - Departament of Fisiology, University of Murcia, 30100 Murcia, Spain. FAU - Morales, Eva AU - Morales E AUID- ORCID: 0000-0003-3145-7022 AD - Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain. AD - Biomedical Research Institute of Murcia (IMIB-Arrixaca), 30120 Murcia, Spain. AD - Division of Preventive Medicine and Public Health, Department of Public Health Sciences, Faculty of Medicine, University of Murcia, 30003 Murcia, Spain. FAU - Vioque, Jesus AU - Vioque J AUID- ORCID: 0000-0002-2284-148X AD - Unidad de Epidemiologia de la Nutricion (EPINUT), Departamento de SaludPublica, Historia de la Ciencia y Ginecologia, Universidad Miguel Hernandez (UMH), 03550 Alicante, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), 03010 Alicante, Spain. AD - Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain. FAU - On Behalf Of The Nela Study Group AU - On Behalf Of The Nela Study Group LA - eng GR - 21871/PI/22/Instituto Murciano de Investigacion Biosanitaria/ GR - RICOR SAMID III, RD21/0012/0002/Maternal and Child Health and Development Research Network/ GR - CP14/00046, PIE15/00051, PI16/ 00422, PI19/00863/Instituto de Salud Carlos III/ GR - RD160006/ARADyAL network/ GR - ESP24PI02/2024/Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica/ GR - PI23/01568/Instituto de Salud Carlos III/ PT - Journal Article PT - Validation Study DEP - 20241222 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Fatty Acids) SB - IM MH - Humans MH - Infant MH - Reproducibility of Results MH - Female MH - Male MH - Surveys and Questionnaires/standards MH - *Diet Surveys/standards MH - Diet/statistics & numerical data MH - Birth Cohort MH - Cohort Studies MH - Nutrition Assessment MH - Mouth Mucosa MH - Fatty Acids/analysis/administration & dosage MH - Energy Intake MH - Feeding Behavior PMC - PMC11677162 OTO - NOTNLM OT - food frequency questionnaire OT - food groups OT - intakes OT - nutrients OT - reproducibility OT - toddler OT - validity COIS- The authors declare no conflicts of interest. EDAT- 2025/01/08 06:20 MHDA- 2025/01/08 06:21 PMCR- 2024/12/22 CRDT- 2025/01/08 01:35 PHST- 2024/11/20 00:00 [received] PHST- 2024/12/18 00:00 [revised] PHST- 2024/12/20 00:00 [accepted] PHST- 2025/01/08 06:21 [medline] PHST- 2025/01/08 06:20 [pubmed] PHST- 2025/01/08 01:35 [entrez] PHST- 2024/12/22 00:00 [pmc-release] AID - nu16244403 [pii] AID - nutrients-16-04403 [pii] AID - 10.3390/nu16244403 [doi] PST - epublish SO - Nutrients. 2024 Dec 22;16(24):4403. doi: 10.3390/nu16244403. PMID- 39770984 OWN - NLM STAT- MEDLINE DCOM- 20250108 LR - 20250110 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 24 DP - 2024 Dec 18 TI - Feasibility and Preliminary Efficacy of Co-Designed and Co-Created Healthy Lifestyle Social Media Intervention Programme the Daily Health Coach for Young Women: A Pilot Randomised Controlled Trial. LID - 10.3390/nu16244364 [doi] LID - 4364 AB - BACKGROUND: Young women spend 50 min daily on social media (SM); thus, SM platforms are promising for health interventions. This study tested the feasibility and preliminary efficacy of the co-designed SM intervention the Daily Health Coach (DHC). The DHC is a 3-month healthy lifestyles intervention programme, targeting eating, physical activity, and social wellbeing behaviours in women aged 18-24, via the dissemination of health and nutrition content on social media platform Instagram. METHODS: The programme was tested using an assessor-blinded, two-arm pilot randomised controlled trial with 46 participants over 12 weeks. Engagement was assessed via SM metrics; acceptability via post-programme questionnaires; and feasibility included retention, randomisation, recruitment, and data collection. Secondary outcomes-dietary quality, physical activity, social influence, disordered eating behaviours, body image, and digital health literacy-were assessed using validated surveys. Analyses included t-tests, chi-squared tests, and linear mixed models. The treatment effects were estimated by testing mean score differences from baseline to 3 months for intention-to-treat populations. RESULTS: The DHC scored 83.6% for programme satisfaction. Over time, a significant decrease in body image disturbance was observed (p = 0.013). A significant group-by-time interaction for digital health literacy (p = 0.002) indicated increased ability to discern evidence-based nutrition information (p = 0.006). The waitlist control group showed increased social influence compared to the intervention group (p = 0.034). No other significant changes were observed. CONCLUSION: The DHC is a feasible and acceptable method for disseminating nutrition information. Larger studies are needed to determine efficacy. FAU - Malloy, Jessica A AU - Malloy JA AUID- ORCID: 0000-0002-5569-1019 AD - Discipline of Nutrition and Dietetics, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road Grafton, Auckland 1011, New Zealand. FAU - Partridge, Stephanie R AU - Partridge SR AUID- ORCID: 0000-0001-5390-3922 AD - Charles Perkins Centre, Faculty of Medicine and Heath, The University of Sydney, Sydney, NSW 2006, Australia. AD - Susan Wakil School of Nursing and Midwifery, The University of Sydney, Sydney, NSW 2050, Australia. FAU - Kemper, Joya A AU - Kemper JA AD - Management, Marketing, and Tourism, University of Canterbury, Christchurch 8041, New Zealand. FAU - Braakhuis, Andrea AU - Braakhuis A AUID- ORCID: 0000-0002-6055-0595 AD - Discipline of Nutrition and Dietetics, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road Grafton, Auckland 1011, New Zealand. FAU - Roy, Rajshri AU - Roy R AUID- ORCID: 0000-0002-7939-1790 AD - Discipline of Nutrition and Dietetics, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road Grafton, Auckland 1011, New Zealand. AD - Charles Perkins Centre, Faculty of Medicine and Heath, The University of Sydney, Sydney, NSW 2006, Australia. AD - Discipline of Nutrition and Dietetics, Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia. LA - eng GR - 89114/The University of Auckland, Graduate Student Funds/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20241218 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - *Social Media MH - Pilot Projects MH - *Feasibility Studies MH - Young Adult MH - Adolescent MH - *Healthy Lifestyle MH - *Exercise MH - Health Promotion/methods MH - Body Image/psychology MH - Health Behavior MH - Feeding Behavior/psychology MH - Health Literacy MH - Diet PMC - PMC11680048 OTO - NOTNLM OT - behavioural health OT - diet OT - health promotion OT - social media intervention OT - young women COIS- The authors declare no conflicts of interest. EDAT- 2025/01/08 06:21 MHDA- 2025/01/08 12:25 PMCR- 2024/12/18 CRDT- 2025/01/08 01:35 PHST- 2024/11/19 00:00 [received] PHST- 2024/12/06 00:00 [revised] PHST- 2024/12/17 00:00 [accepted] PHST- 2025/01/08 12:25 [medline] PHST- 2025/01/08 06:21 [pubmed] PHST- 2025/01/08 01:35 [entrez] PHST- 2024/12/18 00:00 [pmc-release] AID - nu16244364 [pii] AID - nutrients-16-04364 [pii] AID - 10.3390/nu16244364 [doi] PST - epublish SO - Nutrients. 2024 Dec 18;16(24):4364. doi: 10.3390/nu16244364. PMID- 39770928 OWN - NLM STAT- MEDLINE DCOM- 20250128 LR - 20250128 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 24 DP - 2024 Dec 13 TI - Mindful Eating, BMI, Sleep, and Vitamin D: A Cross-Sectional Study of Cypriot and Greek Adults. LID - 10.3390/nu16244308 [doi] LID - 4308 AB - BACKGROUND: Obesity and related health challenges remain significant concerns in Cyprus and Greece. Mindful eating (ME) has emerged as a behavioral approach to address these issues, yet its relationship with BMI, vitamin D levels, and sleep duration in Mediterranean populations is underexplored. OBJECTIVES: This study aimed to examine associations between ME subcategories (Awareness, Distraction, Disinhibition, Emotional, and External Cues), BMI, vitamin D levels, and sleep duration among Cypriot and Greek adults across two cohorts. METHODS: A cross-sectional design was employed with data collected in 2022 (N(1) = 438) and 2023 (N(2) = 174). Participants completed the validated Cyprus Mindful Eating Questionnaire (CyMEQ). Vitamin D levels, sleep duration, and BMI were self-reported. Statistical analyses included Mann-Whitney U Tests for ME subcategory comparisons, chi-square tests for categorical variables, and Spearman correlations to examine associations. RESULTS: Significant differences were found between cohorts in ME subcategories, with N(1) scoring higher in Awareness [Median (IQR): 2.60 (2.20-3.00) vs. 2.00 (1.80-2.30), p = 0.02], Disinhibition [2.70 (2.50-3.00) vs. 2.50 (2.20-2.70), p = 0.03], and External Cues [2.50 (2.10-2.90) vs. 2.10 (1.80-2.50), p = 0.01]. ME scores were negatively correlated with BMI (r = -0.25, p = 0.01) and positively associated with vitamin D levels and sleep duration. Differences in vitamin D supplementation practices were observed across groups; however, these differences did not reach statistical significance (p = 0.07). CONCLUSIONS: ME behaviors, particularly Awareness and Disinhibition, are associated with BMI, highlighting their potential in obesity management. The interplay between ME, vitamin D, and sleep underscores the need for integrative health interventions in Mediterranean populations. FAU - Andreou, Eleni AU - Andreou E AUID- ORCID: 0000-0002-0449-6782 AD - Department of Life Sciences, School of Life and Health Sciences, University of Nicosia, Nicosia 2417, Cyprus. AD - Cyprus Dietetic and Nutrition Association, P.O. Box 28823, Nicosia 2083, Cyprus. AD - MAZI-Eating Disorder and Obesity Foundation in Cyprus, Nicosia 2006, Cyprus. FAU - Mouski, Christiana AU - Mouski C AD - Department of Life Sciences, School of Life and Health Sciences, University of Nicosia, Nicosia 2417, Cyprus. AD - Cyprus Dietetic and Nutrition Association, P.O. Box 28823, Nicosia 2083, Cyprus. FAU - Georgaki, Evridiki AU - Georgaki E AD - MAZI-Eating Disorder and Obesity Foundation in Cyprus, Nicosia 2006, Cyprus. AD - Institute of Health Informatics, University College London, London WC1E 6BT, UK. FAU - Andreou, Nayia AU - Andreou N AD - Cyprus Dietetic and Nutrition Association, P.O. Box 28823, Nicosia 2083, Cyprus. AD - MAZI-Eating Disorder and Obesity Foundation in Cyprus, Nicosia 2006, Cyprus. FAU - Christoforou, Christoforos AU - Christoforou C AD - Department of Life Sciences, School of Life and Health Sciences, University of Nicosia, Nicosia 2417, Cyprus. FAU - Abboud, Myriam AU - Abboud M AD - Department of Health Sciences, College of Natural and Health Sciences, Zayed University (Dubai Campus), Dubai P.O. Box 19282, United Arab Emirates. FAU - Korfiati, Persa AU - Korfiati P AD - Department of Life Sciences, School of Life and Health Sciences, University of Nicosia, Nicosia 2417, Cyprus. AD - MAZI-Eating Disorder and Obesity Foundation in Cyprus, Nicosia 2006, Cyprus. FAU - Kaxiri, Fani AU - Kaxiri F AD - Department of Life Sciences, School of Life and Health Sciences, University of Nicosia, Nicosia 2417, Cyprus. FAU - Papaioannou, Marilena AU - Papaioannou M AD - Department of Life Sciences, School of Life and Health Sciences, University of Nicosia, Nicosia 2417, Cyprus. FAU - Philippou, Christiana AU - Philippou C AD - Cyprus Dietetic and Nutrition Association, P.O. Box 28823, Nicosia 2083, Cyprus. FAU - Papandreou, Dimitrios AU - Papandreou D AUID- ORCID: 0000-0002-4923-484X AD - Department of Clinical Nutrition & Dietetics, College of Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates. FAU - Papaneophytou, Christos AU - Papaneophytou C AUID- ORCID: 0000-0002-4045-8839 AD - Department of Life Sciences, School of Life and Health Sciences, University of Nicosia, Nicosia 2417, Cyprus. LA - eng PT - Journal Article DEP - 20241213 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 1406-16-2 (Vitamin D) SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - *Mindfulness MH - Obesity/epidemiology MH - *Sleep MH - Surveys and Questionnaires MH - *Vitamin D/blood MH - Greece MH - *Feeding Behavior/psychology MH - Vitamin D Deficiency/epidemiology MH - Adolescent MH - Nutritional Status PMC - PMC11678413 OTO - NOTNLM OT - BMI OT - mindful eating OT - mindfulness OT - obesity OT - overweight OT - sleep duration OT - vitamin D COIS- The authors declare no conflicts of interest. EDAT- 2025/01/08 06:20 MHDA- 2025/01/08 12:25 PMCR- 2024/12/13 CRDT- 2025/01/08 01:34 PHST- 2024/11/03 00:00 [received] PHST- 2024/12/06 00:00 [revised] PHST- 2024/12/06 00:00 [accepted] PHST- 2025/01/08 12:25 [medline] PHST- 2025/01/08 06:20 [pubmed] PHST- 2025/01/08 01:34 [entrez] PHST- 2024/12/13 00:00 [pmc-release] AID - nu16244308 [pii] AID - nutrients-16-04308 [pii] AID - 10.3390/nu16244308 [doi] PST - epublish SO - Nutrients. 2024 Dec 13;16(24):4308. doi: 10.3390/nu16244308. PMID- 39767964 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250115 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 11 IP - 12 DP - 2024 Dec 18 TI - Assessment of the Diagnostic Performance of MUAC in Malnutrition Screening and Its Correlation with Other Anthropometric Indicators in Healthy Children and Adolescents. LID - 10.3390/children11121535 [doi] LID - 1535 AB - BACKGROUND/OBJECTIVES: This study aimed to evaluate the correlation of mid-upper arm circumference (MUAC) z-scores with body mass index (BMI) and weight-for-height (WFH) z-scores to determine its reliability in identifying malnutrition and its potential in clinical practice in healthy children and adolescents. METHODS: Our study included 906 healthy children and adolescents aged between 2 months and 18 years who were admitted to University Hospital's General Pediatrics Clinic and attended 12 primary schools in 6 additional Izmir provinces. Anthropometric measurements (weight, length/standing height, MUAC, BMI, WFH) were performed. The relationship between MUAC z-scores, BMI, and WFH z-scores of cases with malnutrition were evaluated. RESULTS: According to the WHO BMI z-score classification, 6 (0.7%) of the children were defined as having severe undernutrition, 43 (4.7%) as moderate undernutrition, 146 (16.1%) as mild undernutrition, 486 (53.6%) as normal, 142 (15.7%) as overweight, and 83 (9.2%) as obese. At any age over two years, fair agreement was observed between MUAC z-scores and WHO BMI z-scores in defining malnutrition alone compared to other growth measures (weighted kappa = 0.371). Under two years of age, the correlation between MUAC z-scores and BMI z-scores showed moderate agreement in detecting overweight and obesity (weighted kappa = 0.479), and between MUAC and WHO WFH z-scores showed moderate agreement (kappa = 0.252). CONCLUSIONS: The study found a moderate and fair connection between MUAC z-scores and other criteria. However, further MUAC z-score screening and diagnostic power testing in larger pediatric populations are needed to validate its use alongside other key anthropometric indicators in malnutrition diagnosis. MUAC measurement should be popularized in routine pediatric outpatient clinics to detect malnutrition quickly. FAU - Durukan, Hatice Esra AU - Durukan HE AUID- ORCID: 0009-0002-4568-4891 AD - Division of General Pediatrics, Department of Pediatrics, Faculty of Medicine, Children's Hospital, Ege University, 35100 Izmir, Turkey. FAU - Dortkardesler, Burce Emine AU - Dortkardesler BE AD - Division of General Pediatrics, Department of Pediatrics, Faculty of Medicine, Children's Hospital, Ege University, 35100 Izmir, Turkey. FAU - Tosyali, Merve AU - Tosyali M AUID- ORCID: 0000-0002-7920-1491 AD - Division of Social Pediatrics, Department of Pediatrics, Faculty of Medicine, Children's Hospital, Ege University, 35100 Izmir, Turkey. FAU - Gokce, Sule AU - Gokce S AD - Division of General Pediatrics, Department of Pediatrics, Faculty of Medicine, Children's Hospital, Ege University, 35100 Izmir, Turkey. FAU - Kurugol, Nuri Zafer AU - Kurugol NZ AD - Division of General Pediatrics, Department of Pediatrics, Faculty of Medicine, Children's Hospital, Ege University, 35100 Izmir, Turkey. FAU - Koc, Feyza AU - Koc F AD - Division of Social Pediatrics, Department of Pediatrics, Faculty of Medicine, Children's Hospital, Ege University, 35100 Izmir, Turkey. LA - eng PT - Journal Article DEP - 20241218 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC11727492 OTO - NOTNLM OT - body mass index OT - malnutrition OT - mid-upper arm circumference OT - obesity OT - undernutrition COIS- The authors declare no conflicts of interest. EDAT- 2025/01/08 06:20 MHDA- 2025/01/08 06:21 PMCR- 2024/12/18 CRDT- 2025/01/08 01:15 PHST- 2024/11/28 00:00 [received] PHST- 2024/12/13 00:00 [revised] PHST- 2024/12/16 00:00 [accepted] PHST- 2025/01/08 06:21 [medline] PHST- 2025/01/08 06:20 [pubmed] PHST- 2025/01/08 01:15 [entrez] PHST- 2024/12/18 00:00 [pmc-release] AID - children11121535 [pii] AID - children-11-01535 [pii] AID - 10.3390/children11121535 [doi] PST - epublish SO - Children (Basel). 2024 Dec 18;11(12):1535. doi: 10.3390/children11121535. PMID- 39766012 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250115 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 12 IP - 24 DP - 2024 Dec 22 TI - Exploring the Association Between Adolescents' Health Literacy and Health Behavior by Using the Short Health Literacy (HLS(19)-Q12) Questionnaire. LID - 10.3390/healthcare12242585 [doi] LID - 2585 AB - BACKGROUND: Health literacy (HL) is an important element of public health that is linked to health behavior in children and adolescents. This study aimed to investigate the structural validity and reliability of the HLS(19)-Q12 in the adolescent population, to measure the general HL of adolescents, and to assess the relationship between adolescents' HL and health behavior. METHODS: This cross-sectional study involved 825 students aged 15-19 years attending Lithuanian gymnasiums. The participants completed an online survey that collected information on key sociodemographic, HL, and health behavior indicators. Factor analysis, Cronbach's alpha, and McDonald's omega were used to validate the Lithuanian version of the HLS(19)-Q12. Health behavior indicators, including physical activity, smoking, alcohol consumption, self-rated health, and body mass index (BMI), were measured. We used regression analyses to assess the associations. RESULTS: The HLS(19)-Q12 showed an acceptable reliability index (Cronbach's alpha = 0.885, McDonald's omega omega = 0.877) and adequate structural validity (comparative fit index = 0.89, Tucker and Lewis's index of fit = 0.88, root mean square error of approximation = 0.06). We found that 67.1% of the adolescents had excellent or sufficient HL, 27.7% had problematic HL, and 5.2% had inadequate HL. Compared with girls, boys had greater HL. HL was positively related to physical activity and self-rated health and negatively related to alcohol use and smoking. CONCLUSIONS: HLS(19)-Q12 is a reliable and valid measure of HL among adolescents in upper grades; higher levels of HL have been found to result in better health behaviors. FAU - Sukys, Saulius AU - Sukys S AUID- ORCID: 0000-0003-0785-2946 AD - Department of Physical and Social Education, Lithuanian Sports University, Sporto g. 6, LT-44221 Kaunas, Lithuania. FAU - Kuzmarskiene, Gerda AU - Kuzmarskiene G AUID- ORCID: 0009-0004-4176-7619 AD - Department of Physical and Social Education, Lithuanian Sports University, Sporto g. 6, LT-44221 Kaunas, Lithuania. FAU - Motiejunaite, Kristina AU - Motiejunaite K AUID- ORCID: 0009-0006-4490-2841 AD - Department of Physical and Social Education, Lithuanian Sports University, Sporto g. 6, LT-44221 Kaunas, Lithuania. LA - eng PT - Journal Article DEP - 20241222 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC11728227 OTO - NOTNLM OT - HLS19-Q12 OT - adolescents OT - health behavior OT - health literacy COIS- The authors declare that they have no conflicts of interest. EDAT- 2025/01/08 06:20 MHDA- 2025/01/08 06:21 PMCR- 2024/12/22 CRDT- 2025/01/08 01:04 PHST- 2024/11/27 00:00 [received] PHST- 2024/12/17 00:00 [revised] PHST- 2024/12/20 00:00 [accepted] PHST- 2025/01/08 06:21 [medline] PHST- 2025/01/08 06:20 [pubmed] PHST- 2025/01/08 01:04 [entrez] PHST- 2024/12/22 00:00 [pmc-release] AID - healthcare12242585 [pii] AID - healthcare-12-02585 [pii] AID - 10.3390/healthcare12242585 [doi] PST - epublish SO - Healthcare (Basel). 2024 Dec 22;12(24):2585. doi: 10.3390/healthcare12242585. PMID- 39765414 OWN - NLM STAT- MEDLINE DCOM- 20250430 LR - 20250520 IS - 1878-1861 (Electronic) IS - 1878-1861 (Linking) VI - 28 IP - 4 DP - 2025 Apr TI - Balance assessment with smartphone devices in para-footballers with cerebral palsy. PG - 337-342 LID - S1440-2440(24)00600-5 [pii] LID - 10.1016/j.jsams.2024.12.009 [doi] AB - OBJECTIVES: To explore whether the mean lumbar acceleration is a feasible tool for determining minimum eligibility criteria to compete in cerebral palsy football, differentiating between new sports classes, and to assess the effect of foot contacts on balance evaluation and class distinction. DESIGN: Cross-sectional study. METHODS: A total of 146 male cerebral palsy footballers classified into FT1 (n=34), FT2 (n=87), and FT3 (n=25), alongside 12 non-impaired athletes as a control group, participated. Two trials of one-leg standing, performed with the more and less affected legs, were measured using a smartphone-based accelerometer. RESULTS: Reliability was moderate-to-excellent (ICC3,1 > 0.70; SEM < 20 %). Significant differences were observed between legs for footballers with cerebral palsy but not for the control group. Mean lumbar acceleration and the number of foot contacts showed significant differences between footballers with cerebral palsy and controls, with pairwise comparisons revealing distinctions between classes. Receiver operating characteristic curves demonstrated high sensitivity and specificity for distinguishing the control group from FT3 using the most affected leg (1.00 [excellent]), with a cutoff score of 0.115 m/s(2) achieving very high sensitivity and specificity. CONCLUSIONS: Mean lumbar acceleration appears to be a suitable metric for assessing minimum impairment criteria for eligibility in para-sports for ambulant athletes with cerebral palsy. However, foot contacts during one-leg standing tests may mask true balance performance in individuals with more severe impairments, which could affect class distinction. CI - Copyright (c) 2024 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved. FAU - Cornejo, M Isabel AU - Cornejo MI AD - Escuela de Kinesiologia, Facultad de Salud, Universidad Santo Tomas, Chile. FAU - Roldan, Alba AU - Roldan A AD - Department of Sport Sciences, Miguel Hernandez University of Elche, Spain. Electronic address: aroldan@umh.es. FAU - Barbado, David AU - Barbado D AD - Department of Sport Sciences, Miguel Hernandez University of Elche, Spain. FAU - Reina, Raul AU - Reina R AD - Department of Sport Sciences, Miguel Hernandez University of Elche, Spain. LA - eng PT - Journal Article DEP - 20241219 PL - Australia TA - J Sci Med Sport JT - Journal of science and medicine in sport JID - 9812598 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology MH - Male MH - *Smartphone MH - Cross-Sectional Studies MH - *Postural Balance MH - *Soccer/physiology MH - *Accelerometry/instrumentation MH - Young Adult MH - Reproducibility of Results MH - Adolescent MH - *Para-Athletes MH - Adult OTO - NOTNLM OT - Brain impairments OT - Classification OT - Equilibrium OT - Football OT - Paralympic OT - Posture COIS- Declaration of interest statement The authors have declared that no competing interests exist. EDAT- 2025/01/08 00:19 MHDA- 2025/04/07 02:02 CRDT- 2025/01/07 21:54 PHST- 2023/12/10 00:00 [received] PHST- 2024/11/17 00:00 [revised] PHST- 2024/12/14 00:00 [accepted] PHST- 2025/04/07 02:02 [medline] PHST- 2025/01/08 00:19 [pubmed] PHST- 2025/01/07 21:54 [entrez] AID - S1440-2440(24)00600-5 [pii] AID - 10.1016/j.jsams.2024.12.009 [doi] PST - ppublish SO - J Sci Med Sport. 2025 Apr;28(4):337-342. doi: 10.1016/j.jsams.2024.12.009. Epub 2024 Dec 19. PMID- 39764319 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260924 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 16 IP - 12 DP - 2024 Dec TI - Obesity Prevalence and Its Impact on Maternal and Neonatal Outcomes in Pregnant Women: A Systematic Review. PG - e75262 LID - 10.7759/cureus.75262 [doi] LID - e75262 AB - Globally, obesity prevalence has progressively increased and is now at epidemic levels; this trend is mirrored in women of childbearing age. There is a high level of evidence that maternal obesity is associated with a range of adverse pregnancy complications and neonatal outcomes, such as hypertensive disorders of pregnancy, gestational diabetes mellitus (GDM), large for gestational age (LGA) fetuses, premature birth, stillbirth, cesarean section, and postpartum hemorrhage, among certain others. This systematic review aimed to comprehensively evaluate the relationship between maternal obesity and health outcomes for both mothers and infants. The inclusion criteria encompass studies focusing on pregnant women with obesity, research examining obesity prevalence in pregnancy, and investigations into various maternal and neonatal outcomes. Quality assessment was performed using the Newcastle-Ottawa Scale to ensure the reliability and validity of findings, while meta-analysis was performed to calculate the pooled prevalence of obesity. The findings highlight significant associations between maternal obesity and adverse outcomes for both mothers and neonates, respectively. Increased gestational weight gain in obese individuals correlates with a higher risk of complications, such as cesarean delivery, preeclampsia, and postpartum hemorrhage. Specifically, obesity has been consistently linked to higher rates of GDM, which further elevates the likelihood of cesarean sections and other complications during labor. Additionally, in terms of neonatal outcomes, studies reveal that maternal obesity influences the incidence of LGA infants, often leading to macrosomia. Neonates born to obese mothers may also have increased rates of NICU admissions, reflecting the challenges posed by higher maternal weight and its associated risks. Maternal obesity is consistently associated with adverse maternal and neonatal outcomes. However, diversity in outcomes, such as Apgar scores, underscores the need for further research to better understand these complex relationships. CI - Copyright (c) 2024, Almutairi et al. FAU - Almutairi, Fai S AU - Almutairi FS AD - Obstetrics and Gynecology, Maternity and Children Hospital, Buraydah, SAU. FAU - Alsaykhan, Alaa M AU - Alsaykhan AM AD - Obstetrics and Gynecology, Maternity and Children Hospital, Buraydah, SAU. FAU - Almatrood, Abrar A AU - Almatrood AA AD - Obstetrics and Gynecology, Maternity and Children Hospital, Hail, SAU. LA - eng PT - Journal Article PT - Review DEP - 20241207 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC11702127 OTO - NOTNLM OT - maternal OT - neonatal OT - obesity OT - outcome OT - pregnancy COIS- Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2025/01/07 06:22 MHDA- 2025/01/07 06:23 PMCR- 2024/12/07 CRDT- 2025/01/07 04:42 PHST- 2024/12/05 00:00 [accepted] PHST- 2025/01/07 06:23 [medline] PHST- 2025/01/07 06:22 [pubmed] PHST- 2025/01/07 04:42 [entrez] PHST- 2024/12/07 00:00 [pmc-release] AID - 10.7759/cureus.75262 [doi] PST - epublish SO - Cureus. 2024 Dec 7;16(12):e75262. doi: 10.7759/cureus.75262. eCollection 2024 Dec. PMID- 39760235 OWN - NLM STAT- MEDLINE DCOM- 20250429 LR - 20260824 IS - 1098-108X (Electronic) IS - 0276-3478 (Print) IS - 0276-3478 (Linking) VI - 58 IP - 4 DP - 2025 Apr TI - TeenGrowth: Individualized Estimations of Weight-Related Risk and Recovery Metrics for Young People With Eating Disorders. PG - 658-668 LID - 10.1002/eat.24372 [doi] AB - OBJECTIVE: While weight restoration and/or stabilization is crucial for successful treatment and sustained recovery from restrictive eating disorders (EDs), it is often challenging to define an individual's expected healthy body weight. This paper introduces the TeenGrowth package and its web-based application, designed to calculate and forecast predicted body mass index (BMI) and weight across adolescence. METHOD: TeenGrowth includes functions for data cleaning, predicted BMI z-score and BMI calculations, and growth forecasting. The accompanying Shiny web application provides a user-friendly interface, enabling the identification of predicted weights for individuals. Through a series of 30 computer-simulated datasets for 1100 individuals (1000 "healthy" and 100 "ED"), the package's options for predictive models are evaluated. RESULTS: Simulation results highlight the potential for use in ED screening and treatment and guide users on modeling options. Prediction of adolescent BMI was more accurate for TeenGrowth models, specifically mean pre-ED BMIz, most recent pre-ED BMIz, or the combination of these metrics (median BMI error for these methods across all simulations = 0.69) when compared to predictions at the 50th percentile of population-based norms (median BMI error = 2.15). Aggregated across simulation approaches, results further support optimal accuracy in identifying ED cases when using mean, most recent, or mean + most recent methods (mean ED case classification accuracy = 0.86) as compared to the use of a population-based metric-85% of the 50th percentile BMI (mean classification accuracy = 0.61). DISCUSSION: The introduction of TeenGrowth represents a first step towards setting reproducible, personalized predicted body weights for young people. CI - (c) 2025 Wiley Periodicals LLC. FAU - Schaumberg, Katherine AU - Schaumberg K AUID- ORCID: 0000-0003-3193-2233 AD - University of Wisconsin-Madison, University of Texas at Austin, Madison, Wisconsin, USA. LA - eng GR - K01 MH123914/MH/NIMH NIH HHS/United States GR - Wisconsin Alumni Research Foundation/ GR - K01MH123914/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20250106 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM MH - Humans MH - Adolescent MH - *Feeding and Eating Disorders/diagnosis/therapy MH - *Body Mass Index MH - Female MH - *Body Weight MH - Male MH - Computer Simulation PMC - PMC11971021 MID - NIHMS2047259 OTO - NOTNLM OT - BMI OT - anorexia nervosa OT - atypical anorexia nervosa OT - recovery EDAT- 2025/01/06 12:23 MHDA- 2025/04/04 06:25 PMCR- 2026/04/01 CRDT- 2025/01/06 06:33 PHST- 2024/12/16 00:00 [revised] PHST- 2024/07/23 00:00 [received] PHST- 2024/12/17 00:00 [accepted] PHST- 2025/04/04 06:25 [medline] PHST- 2025/01/06 12:23 [pubmed] PHST- 2025/01/06 06:33 [entrez] PHST- 2026/04/01 00:00 [pmc-release] AID - 10.1002/eat.24372 [doi] PST - ppublish SO - Int J Eat Disord. 2025 Apr;58(4):658-668. doi: 10.1002/eat.24372. Epub 2025 Jan 6. PMID- 39756471 OWN - NLM STAT- MEDLINE DCOM- 20250106 LR - 20260112 IS - 3022-8247 (Electronic) IS - 3022-7666 (Print) IS - 3022-7666 (Linking) VI - 30 IP - 4 DP - 2024 Dec TI - Dietary interventions to reduce heavy metal exposure in antepartum and postpartum women: a systematic review. PG - 265-276 LID - 10.4069/whn.2024.12.16 [doi] AB - PURPOSE: Heavy metals, which are persistent in the environment and toxic, can accumulate in the body and cause organ damage, which may further negatively affect perinatal women and their fetuses. Therefore, this systematic review was conducted to evaluate the effectiveness of dietary interventions to reduce heavy metal exposure in antepartum and postpartum women. METHODS: We searched five databases (PubMed, Embase, Scopus, Web of Science, and Cochrane Library) for randomized controlled trials that provided dietary interventions for antepartum and postpartum women. Quality assessments were conducted independently by two reviewers using the Cochrane Risk-of-Bias tool, a quality assessment tool for randomized controlled trials. RESULTS: A total of seven studies were included. The studies were conducted in six countries, with interventions categorized into "nutritional supplements," "food supply," and "educational" strategies. Interventions involving nutritional supplements, such as calcium and probiotics, primarily reduced heavy metal levels in the blood and minimized toxicity. Food-based interventions, including specific fruit consumption, decreased heavy metal concentrations in breast milk. Educational interventions effectively promoted behavioral changes, such as adopting diets low in mercury. The studies demonstrated a low overall risk of bias, supporting the reliability of the findings. These strategies underscore the effectiveness of dietary approaches in mitigating heavy metal exposure and improving maternal and child health. CONCLUSION: The main findings underscore the importance of dietary interventions in reducing heavy metal exposure. This emphasizes the critical role of nursing in guiding dietary strategies to minimize exposure risks, ultimately supporting maternal and fetal health during pregnancy. FAU - Heo, Su Ji AU - Heo SJ AD - College of Nursing Science, Kyung Hee University, Seoul, Korea. FAU - Moon, Nalae AU - Moon N AD - College of Nursing Science, Kyung Hee University, Seoul, Korea. FAU - Kim, Ju Hee AU - Kim JH AD - College of Nursing Science, Kyung Hee University, Seoul, Korea. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Systematic Review DEP - 20241230 PL - Korea (South) TA - Womens Health Nurs JT - Women's health nursing (Seoul, Korea) JID - 9918804087906676 RN - 0 (Metals, Heavy) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Metals, Heavy MH - *Postpartum Period MH - *Dietary Supplements MH - Diet MH - Adult PMC - PMC11700719 OTO - NOTNLM OT - Heavy metal OT - Intervention OT - Postpartum OT - Systematic review OT - Antepartum COIS- Conflict of interest Ju Hee Kim has been an editorial board member of Women's Health Nursing since January 2024. She was not involved in the review process of this manuscript. Otherwise, there was no conflict of interest. EDAT- 2025/01/06 10:07 MHDA- 2025/01/07 00:21 PMCR- 2024/12/31 CRDT- 2025/01/05 19:11 PHST- 2024/09/13 00:00 [received] PHST- 2024/12/16 00:00 [accepted] PHST- 2025/01/07 00:21 [medline] PHST- 2025/01/06 10:07 [pubmed] PHST- 2025/01/05 19:11 [entrez] PHST- 2024/12/31 00:00 [pmc-release] AID - whn.2024.12.16 [pii] AID - whn-2024-12-16 [pii] AID - 10.4069/whn.2024.12.16 [doi] PST - ppublish SO - Womens Health Nurs. 2024 Dec;30(4):265-276. doi: 10.4069/whn.2024.12.16. Epub 2024 Dec 30. PMID- 39754137 OWN - NLM STAT- MEDLINE DCOM- 20250106 LR - 20250902 IS - 1479-5868 (Electronic) IS - 1479-5868 (Linking) VI - 22 IP - 1 DP - 2025 Jan 3 TI - A cross-sectional study assessing barriers and facilitators to the sustainability of physical activity and nutrition interventions in early childhood education and care settings. PG - 2 LID - 10.1186/s12966-024-01699-z [doi] LID - 2 AB - BACKGROUND: Effective evidence-based physical activity and nutrition interventions to prevent overweight and obesity and support healthy child development need to be sustained within Early Childhood Education and Care (ECEC) services. Despite this, little is known about factors that influence sustainability of these programs in ECEC settings. Therefore, the aim of this study was to describe the factors related to sustainability of physical activity and nutrition interventions in ECEC settings and examine their association with ECEC service characteristics. METHODS: A cross-sectional study was undertaken with a nationally representative sample of 473 Australian ECEC services. Factors related to the sustainability of ECEC-based physical activity and nutrition interventions were assessed using the validated Integrated Measure of PRogram Element SuStainability in Childcare Settings (IMPRESS-C), measuring Outer Contextual Factors, Inner Contextual Factors, Processes and Characteristics of the Intervention domains for interventions that supervisors reported as currently implementing. Participants responded using a 5-point Likert scale, with responses ranging from 1 (completely disagree) to 5 (completely agree). Domain scores were calculated for each service by averaging item responses. Linear regression models between ECEC service characteristics and the IMPRESS-C domains were undertaken. RESULTS: Data from 473 Australian childcare services nationally found that the domains: Processes ( x =3.78, SD = 0.64), consisting of partnership/engagement and training/support/supervision; and Outer Contextual Factors ( x =3.93, SD = 0.63), including policy and legislation, and socio-political context had the lowest mean scores indicating they may likely be barriers to sustainability. Linear regression analyses revealed no statistically significant associations between examined factors and ECEC service characteristics. There was a statistically significant association between the number of years services delivered their interventions and the Characteristics of the Intervention domain (p = 0.035) suggesting that this domain may influence sustainability of programs. CONCLUSIONS: This study suggests that factors related to the Processes and Outer Contextual Factors domains had the lowest scores and as such, strategies to support the sustainability of physical activity and nutrition interventions implemented in ECEC settings may need to consider how to best address these factors. CI - (c) 2025. The Author(s). FAU - Imad, Noor AU - Imad N AUID- ORCID: 0000-0002-0625-2407 AD - Global Centre for Preventive Health and Nutrition, Institute for Health Transformation, School of Health and Social Development, Faculty of Health, Deakin University, Burwood, VIC, 3125, Australia. s213121488@deakin.edu.au. AD - Hunter New England Population Health, Wallsend, NSW, 2287, Australia. s213121488@deakin.edu.au. AD - School of Health Sciences, Department of Nursing and Allied Health, Swinburne University of Technology, Hawthorn, VIC, 3122, Australia. s213121488@deakin.edu.au. FAU - Hall, Alix AU - Hall A AD - School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, 2308, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. AD - The National Centre of Implementation Science (NCOIS), The University of Newcastle, Newcastle, NSW, Australia. FAU - Nathan, Nicole AU - Nathan N AD - Hunter New England Population Health, Wallsend, NSW, 2287, Australia. AD - School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, 2308, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. AD - The National Centre of Implementation Science (NCOIS), The University of Newcastle, Newcastle, NSW, Australia. FAU - Shoesmith, Adam AU - Shoesmith A AD - Hunter New England Population Health, Wallsend, NSW, 2287, Australia. AD - School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, 2308, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. AD - The National Centre of Implementation Science (NCOIS), The University of Newcastle, Newcastle, NSW, Australia. FAU - Pearson, Nicole AU - Pearson N AD - Hunter New England Population Health, Wallsend, NSW, 2287, Australia. AD - School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, 2308, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. AD - The National Centre of Implementation Science (NCOIS), The University of Newcastle, Newcastle, NSW, Australia. FAU - Lum, Melanie AU - Lum M AD - Global Centre for Preventive Health and Nutrition, Institute for Health Transformation, School of Health and Social Development, Faculty of Health, Deakin University, Burwood, VIC, 3125, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. FAU - Grady, Alice AU - Grady A AD - Hunter New England Population Health, Wallsend, NSW, 2287, Australia. AD - School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, 2308, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. AD - The National Centre of Implementation Science (NCOIS), The University of Newcastle, Newcastle, NSW, Australia. FAU - Nolan, Erin AU - Nolan E AD - School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, 2308, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. AD - The National Centre of Implementation Science (NCOIS), The University of Newcastle, Newcastle, NSW, Australia. FAU - Yoong, Serene AU - Yoong S AD - Global Centre for Preventive Health and Nutrition, Institute for Health Transformation, School of Health and Social Development, Faculty of Health, Deakin University, Burwood, VIC, 3125, Australia. AD - Hunter New England Population Health, Wallsend, NSW, 2287, Australia. AD - School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, 2308, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. AD - The National Centre of Implementation Science (NCOIS), The University of Newcastle, Newcastle, NSW, Australia. LA - eng GR - APP1170042/National Health and Medical Research Council/ GR - GS2000053/National Health and Medical Research Council/ GR - Deakin University/Deakin University/ GR - 102518/Heart Foundation/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250103 PL - England TA - Int J Behav Nutr Phys Act JT - The international journal of behavioral nutrition and physical activity JID - 101217089 SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Exercise MH - Australia MH - Child, Preschool MH - *Child Day Care Centers MH - Female MH - Male MH - *Program Evaluation MH - Pediatric Obesity/prevention & control MH - Health Promotion/methods MH - Child Care/methods PMC - PMC11699775 OTO - NOTNLM OT - Children OT - Early childhood education and care OT - Facilitators OT - Nutrition OT - Physical activity OT - Prevention barriers OT - Sustainability OT - Sustainment COIS- Declarations. Ethics approval and consent to participate: Ethical approval was provided by Hunter New England HREC (06/07/26/4.04 2019/ETH12353) and University of Newcastle HREC (H-2008-0343). Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interest. EDAT- 2025/01/04 00:20 MHDA- 2025/01/07 00:21 PMCR- 2025/01/03 CRDT- 2025/01/03 23:56 PHST- 2024/07/30 00:00 [received] PHST- 2024/12/18 00:00 [accepted] PHST- 2025/01/07 00:21 [medline] PHST- 2025/01/04 00:20 [pubmed] PHST- 2025/01/03 23:56 [entrez] PHST- 2025/01/03 00:00 [pmc-release] AID - 10.1186/s12966-024-01699-z [pii] AID - 1699 [pii] AID - 10.1186/s12966-024-01699-z [doi] PST - epublish SO - Int J Behav Nutr Phys Act. 2025 Jan 3;22(1):2. doi: 10.1186/s12966-024-01699-z. PMID- 39752408 OWN - NLM STAT- MEDLINE DCOM- 20250103 LR - 20260924 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 1 DP - 2025 TI - Factors affecting behaviors during complementary feeding in infants and children aged 6-24 months. PG - e0314694 LID - 10.1371/journal.pone.0314694 [doi] LID - e0314694 AB - The process that begins around the 6th month of life and continues until the 24th month is called the complementary feeding period. During this period, infants and children start receiving foods that complement breast milk or formula for the first time. The psychosocial factors the infants and children encounter during this period may affect their growth and health in later life. This cross-sectional and descriptive study aimed to examine the factors influencing behaviors of infants and children during complementary feeding. The study sample included 345 mothers with infants and children aged 6-24 months. The research data were collected using two forms and one scale. The first form contained questions about the mothers' sociodemographic characteristics, sources of support in childcare, and information sources related to complementary feeding. The second form contained questions about the sociodemographic characteristics of infants and children, the presence of allergies, breastfeeding, and feeding status. The scale used was the validated Behaviors of Transition to Complementary Feeding Scale. The effect of independent variables on behavior of infants and children during complementary feeding was examined using multiple linear regression analysis. Infants/children older than 12 months exhibited more negative behaviors during complementary feeding compared with those aged 6-12 months. The study also found that being the first infant/child in the family had a negative impact on behaviors during complementary feeding. Infants and children currently receiving only complementary feeding displayed more positive behaviors during the complementary feeding process. Paternal support in childcare positively influenced behaviors during this period. In conclusion, complementary feeding is a multifaceted process influenced by various factors, including the infant's and child's age, family dynamics, and parental support. Strategies to support mothers, involve fathers, and provide reliable information can facilitate a smoother process of complementary feeding and promote healthier feeding behaviors in infants and children. Descriptive, interventional, qualitative, and mixed-methods studies are required to analyze these factors in detail and improve the complementary feeding process. CI - Copyright: (c) 2025 Demirel Ozbek et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Demirel Ozbek, Yagmur AU - Demirel Ozbek Y AUID- ORCID: 0000-0003-3877-3183 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Recep Tayyip Erdogan University, Rize, Turkey. FAU - Celik, Isa AU - Celik I AUID- ORCID: 0000-0003-3381-2286 AD - Department of Pediatric Nursing, Faculty of Health Sciences, Recep Tayyip Erdogan University, Rize, Turkey. FAU - Sahin Bilgin, Aysenur AU - Sahin Bilgin A AD - Vitamince Nutrition Counseling, Maltepe/Istanbul, Turkey. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250103 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Infant MH - Female MH - Male MH - Cross-Sectional Studies MH - *Infant Nutritional Physiological Phenomena MH - Child, Preschool MH - *Feeding Behavior/psychology/physiology MH - *Breast Feeding/psychology MH - Mothers/psychology MH - Adult MH - Infant Behavior/physiology PMC - PMC11698433 COIS- The authors have declared that no competing interests exist. EDAT- 2025/01/03 18:20 MHDA- 2025/01/03 18:21 PMCR- 2025/01/03 CRDT- 2025/01/03 13:43 PHST- 2024/07/17 00:00 [received] PHST- 2024/11/15 00:00 [accepted] PHST- 2025/01/03 18:21 [medline] PHST- 2025/01/03 18:20 [pubmed] PHST- 2025/01/03 13:43 [entrez] PHST- 2025/01/03 00:00 [pmc-release] AID - PONE-D-24-27768 [pii] AID - 10.1371/journal.pone.0314694 [doi] PST - epublish SO - PLoS One. 2025 Jan 3;20(1):e0314694. doi: 10.1371/journal.pone.0314694. eCollection 2025. PMID- 39750736 OWN - NLM STAT- MEDLINE DCOM- 20250929 LR - 20260607 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) VI - 36 IP - 2 DP - 2025 Mar-Apr 01 TI - The True Appearance Behind Satisfaction in Young Women: A Study Using Stereophotogrammetry and FACE-Q. PG - 643-646 LID - 10.1097/SCS.0000000000011047 [doi] AB - This cross-sectional observational study aimed to investigate the relationship between satisfaction with facial appearance among young women, as measured by the FACE-Q tool, and facial asymmetry quantified through stereophotogrammetry. A total of 50 women aged 18 to 30 years with a normal body mass index were recruited for the study. Participants were categorized as either symmetrical or asymmetrical based on facial asymmetry assessments obtained through clinical examination and stereophotogrammetry using the Vectra M3 system. Facial asymmetry was quantified using root mean square (RMS) distances, with participants classified into symmetrical (RMS 0.68) groups. The statistical analysis included the intraclass correlation coefficient (ICC) to assess the repeatability of RMS measurements (ICC=0.945), Receiver operating characteristic (ROC) curve analysis (area under the curve=0.900), and independent t tests to compare FACE-Q scores between groups. Results showed no significant differences in FACE-Q satisfaction scores between the symmetrical and asymmetrical groups. In addition, simple linear regression analysis indicated that RMS values were not predictive of FACE-Q scores, suggesting that facial asymmetry, as measured in this study, did not have a direct effect on self-reported satisfaction with appearance. These findings highlight the nuanced nature of individual satisfaction with facial appearance, suggesting that health care providers should combine clinical evaluation with empathetic communication to address both the aesthetic and functional concerns of patients more effectively. CI - Copyright (c) 2025 by Mutaz B. Habal, MD. FAU - Andrade, Lilian Mendes AU - Andrade LM AD - Department of Basic and Oral Biology, Ribeirao Preto School of Dentistry, University of Sao Paulo. FAU - Fernandes, Anna Luisa Alves AU - Fernandes ALA AD - Department of Basic and Oral Biology, Ribeirao Preto School of Dentistry, University of Sao Paulo. FAU - Magri, Lais Valencise AU - Magri LV AD - Department of Restorative Dentistry, School of Dentistry of Ribeirao Preto. FAU - Mazzi-Chaves, Jardel Francisco AU - Mazzi-Chaves JF AD - Department of Restorative Dentistry, School of Dentistry of Ribeirao Preto. FAU - de Vasconcelos, Paulo Batista AU - de Vasconcelos PB AD - Department of Basic and Oral Biology, Ribeirao Preto School of Dentistry, University of Sao Paulo. FAU - Siessere, Selma AU - Siessere S AD - Department of Basic and Oral Biology, Ribeirao Preto School of Dentistry, University of Sao Paulo. AD - National Institute and Technology-Translational Medicine (INCT.TM), University of Sao Paulo (USP), Ribeirao Preto, SP Brazil. FAU - Regalo, Simone Cecilio Hallak AU - Regalo SCH AD - Department of Basic and Oral Biology, Ribeirao Preto School of Dentistry, University of Sao Paulo. AD - National Institute and Technology-Translational Medicine (INCT.TM), University of Sao Paulo (USP), Ribeirao Preto, SP Brazil. FAU - Palinkas, Marcelo AU - Palinkas M AD - Department of Basic and Oral Biology, Ribeirao Preto School of Dentistry, University of Sao Paulo. AD - National Institute and Technology-Translational Medicine (INCT.TM), University of Sao Paulo (USP), Ribeirao Preto, SP Brazil. LA - eng PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20250103 PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 SB - IM MH - Humans MH - Female MH - *Photogrammetry/methods MH - Adult MH - Cross-Sectional Studies MH - Adolescent MH - Young Adult MH - *Facial Asymmetry/psychology/diagnostic imaging MH - *Personal Satisfaction OTO - NOTNLM OT - FACE-Q OT - facial asymmetry OT - self-satisfaction OT - stereophotogrammetry OT - young women COIS- The authors report no conflicts of interest. EDAT- 2025/01/03 12:22 MHDA- 2025/09/29 13:19 CRDT- 2025/01/03 10:23 PHST- 2024/11/25 00:00 [received] PHST- 2024/12/13 00:00 [accepted] PHST- 2025/09/29 13:19 [medline] PHST- 2025/01/03 12:22 [pubmed] PHST- 2025/01/03 10:23 [entrez] AID - 00001665-990000000-02325 [pii] AID - 10.1097/SCS.0000000000011047 [doi] PST - ppublish SO - J Craniofac Surg. 2025 Mar-Apr 01;36(2):643-646. doi: 10.1097/SCS.0000000000011047. Epub 2025 Jan 3. PMID- 39749089 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250104 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 16 IP - 12 DP - 2024 Dec TI - Predicting Microvascular Invasion in Liver Transplant Recipients for Hepatocellular Carcinoma. PG - e75007 LID - 10.7759/cureus.75007 [doi] LID - e75007 AB - BACKGROUND: Among primary liver tumors, hepatocellular carcinoma (HCC) is considered the most common hepatic tumor. Liver transplantation is one of the curative treatment options for HCC. However, the risk of HCC recurrence after liver transplantation varies and is influenced by various factors. Microvascular invasion (MVI) is a major factor associated with HCC recurrence after a liver transplant (LT). The study assessed the pre-transplant factors to predict MVI on explant liver specimens. METHODS: The retrospective study included adult LT recipients with HCC on explant specimens to identify pre-transplant predictors of MVI. Univariate analyses, including Mann-Whitney U tests and chi-square tests, were conducted to assess associations between variables and MVI. Logistic regression was employed for multivariate analysis, including variables significant in univariate analysis. Pearson or Spearman correlation coefficients were calculated to examine correlations between continuous variables. Cohen's kappa coefficient was used to measure inter-rater reliability. RESULTS: Out of 523 LT recipients, 136 (26%) were diagnosed with HCC based on pre-transplant imaging and histopathological analysis of the explanted liver. Descriptive data showed an average age of 54.06 +/- 8.16 years (range: 15-70), with a majority being male (76.47%). Hepatitis C (HCV) was the leading etiology (72.8%). Most patients had moderately differentiated grade-II tumors (75.7%) and met the Milan criteria (74.3%). Mean pre-operative alpha-fetoprotein (pre-op AFP) levels were 104.42 +/- 308.38 ng/ml. 74.3% were within the Milan criteria. MVI was present in 28.7%. The frequency of MVI among HCCs within vs. outside Milan criteria was not statistically significant (26.73% vs. 34.28% (p = 0.395)). Univariate analysis revealed that pre-op AFP levels (p = 0.001), Child-Turcotte Pugh class (p=0.05), and body mass index (p=0.02) were significantly associated with MVI. Multivariate logistic regression analysis showed that pre-op AFP was the only independent predictor of MVI (OR: 1.006, 95% CI: 1.003-1.008, p < 0.001). CONCLUSION: This study not only reinforces the clinical significance of pre-op AFP levels as a simple pre-transplant predictor of MVI in patients with HCC but also advocates for the safety of liver transplantation beyond conventional Milan criteria, promoting extended LT protocols. CI - Copyright (c) 2024, Aujla et al. FAU - Aujla, Usman I AU - Aujla UI AD - Gastroenterology and Hepatology, Pakistan Kidney and Liver Institute and Research Center, Lahore, PAK. FAU - Syed, Imran Ali AU - Syed IA AD - Gastroenterology and Hepatology, Pakistan Kidney and Liver Institute and Research Center, Lahore, PAK. FAU - Rafi, Kashif AU - Rafi K AD - Gastroenterology, Pakistan Kidney and Liver Institute and Research Center, Lahore, PAK. FAU - Naveed, Ammara AU - Naveed A AD - Hepatology, Pakistan Kidney and Liver Institute and Research Center, Lahore, PAK. FAU - Malik, Ahmad K AU - Malik AK AD - Adult Gastroenterology, Pakistan Kidney and Liver Institute and Research Center, Lahore, PAK. FAU - Khan, Muhammad Yasir AU - Khan MY AD - Hepatopancreatobiliary and Liver Transplant Surgery, Pakistan Kidney and Liver Institute and Research Center, Lahore, PAK. FAU - Haq, Ihsan Ul AU - Haq IU AD - Hepatopancreatobiliary and Liver Transplant Surgery, Pakistan Kidney and Liver Institute and Research Center, Lahore, PAK. FAU - Rashid, Sohail AU - Rashid S AD - Hepatopancreatobiliary and Liver Transplant Surgery, Pakistan Kidney and Liver Institute and Research Center, Lahore, PAK. FAU - Butt, Osama T AU - Butt OT AD - Gastroenterology and Hepatology, Pakistan Kidney and Liver Institute and Research Center, Lahore, PAK. FAU - Dar, Faisal AU - Dar F AD - Hepatopancreatobiliary and Liver Transplant Surgery, Pakistan Kidney and Liver Institute and Research Center, Lahore, PAK. LA - eng PT - Journal Article DEP - 20241202 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC11694041 OTO - NOTNLM OT - alpha-fetoprotein OT - hepatocellular carcinoma (hcc) OT - liver transplant OT - microvascular invasion OT - milan criteria COIS- Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Review Board of Pakistan Kidney and Liver Institute & Research Center issued approval PKLI-IRB/AP/170. This study was conducted following the Declaration of Helsinki and approved by the Institutional Review Board of Pakistan Kidney and Liver Institute & Research Center (Approval No. [PKLI-IRB/AP/170]). Given the study's retrospective nature, informed consent was waived by the Institutional Review Board, and all data were anonymized before analysis to protect the privacy and confidentiality of the participants. No animals or prisoners were included in the study. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2025/01/03 06:21 MHDA- 2025/01/03 06:22 PMCR- 2024/12/02 CRDT- 2025/01/03 04:15 PHST- 2024/12/02 00:00 [accepted] PHST- 2025/01/03 06:22 [medline] PHST- 2025/01/03 06:21 [pubmed] PHST- 2025/01/03 04:15 [entrez] PHST- 2024/12/02 00:00 [pmc-release] AID - 10.7759/cureus.75007 [doi] PST - epublish SO - Cureus. 2024 Dec 2;16(12):e75007. doi: 10.7759/cureus.75007. eCollection 2024 Dec. PMID- 39747315 OWN - NLM STAT- MEDLINE DCOM- 20250103 LR - 20250326 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Jan 2 TI - Validity and reliability of the step test to estimate maximal oxygen consumption in pediatric population. PG - 592 LID - 10.1038/s41598-024-84336-w [doi] LID - 592 AB - Cardiorespiratory fitness is the most important variable related to health and a strong predictor of mortality. However, it is rarely used in clinics due to costs, specialized equipment, space needs, and the requirements of expert staff such as an exercise physiologist, physician, or other health professional. This work aims to validate and test the reliability of a submaximal step test to estimate VO(2)max of 8-to 16-year-old pediatric populations as a simple and low-cost tool for clinical practice. A cross-sectional study included 242 children and adolescents (42.1% girls) aged 8-16. Cardiorespiratory fitness was determined by a maximal incremental test on a treadmill until exhaustion. The step test entailed maintaining a steady pace of 22 steps per minute for 3 min (60 bpm), with the heart rate being recorded at the end of the test. Nutritional status was computed through BMI z-score. A multiple linear regression model validated the step test and developed a new equation to predict VO(2)max, including the third-minute heart rate, weight, and height. The reliability among predicted and measured VO(2)max was assessed by Bland-Altman analysis. The mean age was 12.5 +/- 2.6; 51.6% were overweight or obese. The cardiorespiratory fitness measured as VO(2)max was 35.01 +/- 0.58 ml.min-(1).kg(-1). A robust correlation was observed between the predicted VO(2)max from the step test and the measured VO(2)max (r = 0.86, p < 0.001). Bland-Altman analysis indicated statistical concordance between predicted and measured VO(2)max. Our findings indicate that the step test protocol is valid and reliable for estimating VO(2)max in children and adolescents. Furthermore, the predictive equation is suitable for application among children aged 8-16. CI - (c) 2024. The Author(s). FAU - Weisstaub, Gerardo AU - Weisstaub G AD - Laboratory of Nutritional Evaluation and Body Composition, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile. FAU - Gonzalez, Jose AU - Gonzalez J AD - Laboratory of Nutrition and Physical Activity Research (LABINAF), Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile. FAU - Orizola, Ignacio AU - Orizola I AD - Unidad de Fisiologia Clinica del Ejercicio, Centro de Especialidades Medicas y Odontologicas, Direccion de Salud IM, El Bosque, Santiago, Chile. FAU - Borquez, Juan AU - Borquez J AD - Facultad de Ciencias de la Salud, Universidad de Magallanes, Punta Arenas, Chile. AD - Centro de Excelencia en Biomedicina de Magallanes (CEBIMA), Universidad de Magallanes, Punta Arenas, Chile. FAU - Monsalves-Alvarez, Matias AU - Monsalves-Alvarez M AD - Exercise and Rehabilitation Sciences Institute, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago, Chile. FAU - Lera, Lydia AU - Lera L AD - Latin Division, Keiser University, Fort Laurderdale, USA. FAU - Troncoso, Rodrigo AU - Troncoso R AD - Laboratory of Nutrition and Physical Activity Research (LABINAF), Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile. FAU - Sepulveda, Carlos AU - Sepulveda C AD - Laboratory of Nutrition and Physical Activity Research (LABINAF), Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile. carlos.sepulveda@uoh.cl. AD - Instituto de Ciencias de la Salud, Universidad de O'Higgins, Rancagua, Chile. carlos.sepulveda@uoh.cl. LA - eng GR - SA19I0106/Fondo de Investigacion y Desarrollo en Salud - Fonis/ GR - SA19I0106/Fondo de Investigacion y Desarrollo en Salud - Fonis/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250102 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - *Oxygen Consumption/physiology MH - Adolescent MH - *Exercise Test/methods MH - *Cardiorespiratory Fitness/physiology MH - Cross-Sectional Studies MH - Reproducibility of Results MH - Heart Rate/physiology PMC - PMC11696093 OTO - NOTNLM OT - Cardiorespiratory fitness OT - Children OT - Exercise testing OT - Heart rate. COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/01/03 00:20 MHDA- 2025/01/03 06:21 PMCR- 2025/01/02 CRDT- 2025/01/02 23:43 PHST- 2024/08/18 00:00 [received] PHST- 2024/12/23 00:00 [accepted] PHST- 2025/01/03 06:21 [medline] PHST- 2025/01/03 00:20 [pubmed] PHST- 2025/01/02 23:43 [entrez] PHST- 2025/01/02 00:00 [pmc-release] AID - 10.1038/s41598-024-84336-w [pii] AID - 84336 [pii] AID - 10.1038/s41598-024-84336-w [doi] PST - epublish SO - Sci Rep. 2025 Jan 2;15(1):592. doi: 10.1038/s41598-024-84336-w. PMID- 39746670 OWN - NLM STAT- MEDLINE DCOM- 20250702 LR - 20260803 IS - 1365-2869 (Electronic) IS - 0962-1105 (Print) IS - 0962-1105 (Linking) VI - 34 IP - 4 DP - 2025 Aug TI - Validation of the Morningness-Eveningness Scale for Children (MESC) with ambulatory circadian monitoring of temperature, light exposure and activity. PG - e14444 LID - 10.1111/jsr.14444 [doi] LID - e14444 AB - The external validity of the Morningness-Eveningness Scale for Children was analysed via objective measures of skin temperature, light exposure and motor activity with the ambulatory circadian monitoring methodology. A total of 138 adolescents (57 boys and 81 girls) aged 12-13 years, who in addition to completing the Morningness-Eveningness Scale for Children to determine their circadian typology wore a wrist activity device (Kronowise 3.0; Kronohealth SL) during school days and a weekend, participated. Circadian parameters, such as mesor, amplitude and acrophase, were estimated for skin temperature, light exposure and motor activity, as were sleep parameters, such as risetime, bedtime and social jetlag. The results indicated that during the weekend E-type adolescents experienced later acrophases in temperature, light and activity than I-type and M-type adolescents did, whereas boys experienced earlier acrophases in temperature and activity. When school weekdays were compared with the weekend, there was a weekend delay in the acrophases of temperature (1:03), light exposure (2:03) and activity (3:15). The results obtained in this study provide external validity for applying the Morningness-Eveningness Scale for Children in the naturalistic context of high school while considering sex and type-of-day differences as important variables in chronopsychological studies. CI - (c) 2025 The Author(s). Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society. FAU - Puig-Navarro, Yaiza AU - Puig-Navarro Y AUID- ORCID: 0000-0002-9936-4108 AD - Individual Differences, Work and Social Psychology Department, Complutense University of Madrid; R&D department, Hogrefe TEA Ediciones, Madrid, Spain. FAU - Diaz-Morales, Juan F AU - Diaz-Morales JF AUID- ORCID: 0000-0002-3894-7908 AD - Individual Differences, Work and Social Psychology Department, Complutense University of Madrid, Madrid, Spain. LA - eng GR - PID2020-116600RB-I00/Ministerio de Ciencia e Innovacion/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20250102 PL - England TA - J Sleep Res JT - Journal of sleep research JID - 9214441 SB - IM MH - Humans MH - Male MH - Female MH - Child MH - Adolescent MH - *Circadian Rhythm/physiology MH - Skin Temperature/physiology MH - *Monitoring, Ambulatory/methods MH - Sleep/physiology MH - *Motor Activity/physiology MH - *Light MH - Reproducibility of Results MH - Temperature PMC - PMC12215289 OTO - NOTNLM OT - adolescents OT - circadian parameters OT - circadian preference OT - sleep parameters COIS- The authors assert they have no conflict of interest with any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript. EDAT- 2025/01/03 00:20 MHDA- 2025/07/02 12:28 PMCR- 2025/07/02 CRDT- 2025/01/02 19:52 PHST- 2024/11/29 00:00 [revised] PHST- 2024/11/01 00:00 [received] PHST- 2024/12/07 00:00 [accepted] PHST- 2025/07/02 12:28 [medline] PHST- 2025/01/03 00:20 [pubmed] PHST- 2025/01/02 19:52 [entrez] PHST- 2025/07/02 00:00 [pmc-release] AID - JSR14444 [pii] AID - 10.1111/jsr.14444 [doi] PST - ppublish SO - J Sleep Res. 2025 Aug;34(4):e14444. doi: 10.1111/jsr.14444. Epub 2025 Jan 2. PMID- 39746619 OWN - NLM STAT- MEDLINE DCOM- 20250429 LR - 20260701 IS - 1873-6823 (Electronic) IS - 0741-8329 (Linking) VI - 122 DP - 2025 Feb TI - Understanding drunkorexia behaviors among college students using the theory of planned behavior. PG - 55-61 LID - S0741-8329(24)00197-6 [pii] LID - 10.1016/j.alcohol.2024.12.008 [doi] AB - Drunkorexia refers to high-risk behaviors that involve the intersection of disordered eating behaviors and risky alcohol consumption. This study utilized the extended Theory of Planned Behavior (TPB) to identify potential psychosocial factors that contribute to drunkorexia among students (484 undergraduate students) from a midwestern Mid-sized university. This cross-sectional study used online surveys designed to measure various drunkorexia-related behaviors including alcohol consumption, calorie restriction, excessive exercise, and purging utilizing antecedents of the TPB. About one-fourth of participants reported engagement in drunkorexia. The extended TPB model reported strong predictive validity for intention for calorie restriction, excessive exercise, and purging with instrumental attitudes and capacity being significant predictors for all three behaviors. Findings provide more profound insight regarding patterns of drunkorexia that could inform future theory-based interventions to address drunkorexia among college students. CI - Copyright (c) 2024 Elsevier Inc. All rights reserved. FAU - Bhochhibhoya, Amir AU - Bhochhibhoya A AD - New Jersey Department of Health, Trenton, NJ, USA. FAU - Speed, Shannon N AU - Speed SN AD - Department of Health Behavior and Nutrition Sciences, University of Delaware, Newark, DE, USA. FAU - Ward, Rose Marie AU - Ward RM AD - Graduate College, University of Cincinnati, Cincinnati, OH, USA. FAU - Branscum, Paul AU - Branscum P AD - Department of Kinesiology, Nutrition, and Health, Miami University, Oxford, OH, USA. Electronic address: branscpw@miamioh.edu. LA - eng PT - Journal Article DEP - 20241231 PL - United States TA - Alcohol JT - Alcohol (Fayetteville, N.Y.) JID - 8502311 SB - IM MH - Humans MH - Female MH - Male MH - *Students/psychology MH - Young Adult MH - Cross-Sectional Studies MH - Universities MH - Adolescent MH - *Alcohol Drinking in College/psychology MH - Adult MH - Exercise/psychology MH - *Psychological Theory MH - *Alcohol Drinking/psychology MH - Surveys and Questionnaires MH - Theory of Planned Behavior OTO - NOTNLM OT - Alcohol OT - College students OT - Disordered eating OT - Drunkorexia OT - Theory of Planned Behavior COIS- Declaration of competing interest The authors have no conflicts of interest to report. The authors confirm that the research presented in this article met the ethical guidelines, including adherence to the legal requirements, of the United States, and received approval from the Institutional Review Board of Miami University, Oxford, OH. EDAT- 2025/01/03 00:20 MHDA- 2025/01/24 00:26 CRDT- 2025/01/02 19:17 PHST- 2024/04/03 00:00 [received] PHST- 2024/12/23 00:00 [revised] PHST- 2024/12/30 00:00 [accepted] PHST- 2025/01/24 00:26 [medline] PHST- 2025/01/03 00:20 [pubmed] PHST- 2025/01/02 19:17 [entrez] AID - S0741-8329(24)00197-6 [pii] AID - 10.1016/j.alcohol.2024.12.008 [doi] PST - ppublish SO - Alcohol. 2025 Feb;122:55-61. doi: 10.1016/j.alcohol.2024.12.008. Epub 2024 Dec 31. PMID- 39745453 OWN - NLM STAT- MEDLINE DCOM- 20250404 LR - 20260813 IS - 1550-9397 (Electronic) IS - 1550-9389 (Print) IS - 1550-9389 (Linking) VI - 21 IP - 4 DP - 2025 Apr 1 TI - Comparison of WatchPAT to polysomnography measurement of apnea-hypopnea index and obstructive sleep apnea severity in adolescents with overweight and obesity. PG - 695-702 LID - 10.5664/jcsm.11530 [doi] AB - STUDY OBJECTIVES: The prevalence of obstructive sleep apnea (OSA) increases dramatically in adolescents with overweight or obesity. The gold standard for diagnosis of OSA is in-laboratory polysomnography (PSG). However, access to PSG can be challenging, necessitating development of alternative devices. This study aimed to compare the accuracy of WatchPAT, a device that indirectly detects apnea and hypopnea events through peripheral arterial tonometry, to PSG in adolescents with overweight and obesity. METHODS: Thirty-eight participants (15.5 +/- 1.6 years; 76% female; 40% Hispanic/Latino; body mass index 97.7 +/- 2.0 percentile) were analyzed. Correlation, agreement, sensitivity, specificity, and concordance between WatchPAT with PSG-derived measures of apnea-hypopnea index (AHI) and OSA severity were conducted. A subset (n = 21) underwent self-reported assessment of nasal flow sensor reliability and video characteristics to evaluate possible underestimation of PSG-assessed AHI. RESULTS: Mean bias between WatchPAT- and PSG-derived AHI was 16.9 +/- 13.4 events/h (95% confidence interval 12.5-21.3). WatchPAT overestimated OSA severity compared to PSG in 89% of participants. Sensitivity was 62-100% and specificity was 5.5-32% across all OSA severity levels. Of the subset with self-reported assessment of PSG data, 38% had nasal flow sensor reliability < 75%, 14% had underestimated AHI, and 28% had probably underestimated AHI. However, these characteristics did not fully explain the discrepancy between WatchPAT and PSG measurements. CONCLUSIONS: The WatchPAT device showed a significant discrepancy compared to the gold-standard PSG in measurement of AHI and accuracy of OSA severity in adolescents with overweight or obesity. Future research is needed to understand pathophysiological differences to enhance assessment of OSA in this high-risk population. CITATION: Dobbin ML, Bernard A, Pyle L, et al. Comparison of WatchPAT to polysomnography measurement of apnea-hypopnea index and obstructive sleep apnea severity in adolescents with overweight and obesity. J Clin Sleep Med. 2025;21(4):695-702. CI - (c) 2025 American Academy of Sleep Medicine. FAU - Dobbin, Mia L AU - Dobbin ML AD - Rocky Vista University College of Osteopathic Medicine, Parker, Colorado. AD - Children's Hospital Colorado, Aurora, Colorado. FAU - Bernard, Angel AU - Bernard A AD - Children's Hospital Colorado, Aurora, Colorado. AD - University of Colorado Anschutz Medical Campus, Aurora, Colorado. FAU - Pyle, Laura AU - Pyle L AD - Children's Hospital Colorado, Aurora, Colorado. AD - University of Colorado Anschutz Medical Campus, Aurora, Colorado. FAU - Friedman, Norman AU - Friedman N AD - Children's Hospital Colorado, Aurora, Colorado. AD - University of Colorado Anschutz Medical Campus, Aurora, Colorado. FAU - Cree, Melanie G AU - Cree MG AD - Children's Hospital Colorado, Aurora, Colorado. AD - University of Colorado Anschutz Medical Campus, Aurora, Colorado. FAU - Hawkins, Stephen M M AU - Hawkins SMM AD - Children's Hospital Colorado, Aurora, Colorado. AD - University of Colorado Anschutz Medical Campus, Aurora, Colorado. FAU - Simon, Stacey L AU - Simon SL AD - Children's Hospital Colorado, Aurora, Colorado. AD - University of Colorado Anschutz Medical Campus, Aurora, Colorado. LA - eng GR - P30 DK048520/DK/NIDDK NIH HHS/United States PT - Comparative Study PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PL - Switzerland TA - J Clin Sleep Med JT - Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine JID - 101231977 SB - IM MH - Humans MH - *Sleep Apnea, Obstructive/diagnosis/complications MH - Female MH - *Polysomnography/methods/instrumentation MH - Male MH - Adolescent MH - Severity of Illness Index MH - Reproducibility of Results MH - *Overweight/complications MH - *Pediatric Obesity/complications MH - Sensitivity and Specificity PMC - PMC11965089 OTO - NOTNLM OT - BMI OT - home sleep apnea test OT - pediatrics OT - peripheral arterial tonometry OT - sleep medicine OT - sleep-disordered breathing OT - validation COIS- All authors have seen and approved this manuscript. Work was performed at Children's Hospital Colorado and the University of Colorado Anschutz Medical Campus. This work was supported by the Department of Pediatrics, University of Colorado Anschutz Medical Campus. All authors report no conflicts of interest. EDAT- 2025/01/02 12:24 MHDA- 2025/04/04 06:25 PMCR- 2026/04/01 CRDT- 2025/01/02 10:43 PHST- 2025/04/04 06:25 [medline] PHST- 2025/01/02 12:24 [pubmed] PHST- 2025/01/02 10:43 [entrez] PHST- 2026/04/01 00:00 [pmc-release] AID - jcsm.11530 [pii] AID - JC2400371 [pii] AID - 10.5664/jcsm.11530 [doi] PST - ppublish SO - J Clin Sleep Med. 2025 Apr 1;21(4):695-702. doi: 10.5664/jcsm.11530. PMID- 39742657 OWN - NLM STAT- MEDLINE DCOM- 20250316 LR - 20260415 IS - 1095-8673 (Electronic) IS - 0022-4804 (Print) IS - 0022-4804 (Linking) VI - 306 DP - 2025 Feb TI - Using Machine Learning to Predict Weight Gain in Adults: an Observational Analysis From the All of Us Research Program. PG - 43-53 LID - S0022-4804(24)00787-X [pii] LID - 10.1016/j.jss.2024.11.042 [doi] AB - INTRODUCTION: Obesity, defined as a body mass index >/=30 kg/m(2), is a major public health concern in the United States. Preventative approaches are essential, but they are limited by an inability to accurately predict individuals at highest risk of weight gain. Our objective was to develop accurate weight gain prediction models using the National Institutes of Health All of Us dataset. We hypothesized that machine learning models using both electronic health record and behavioral survey data would outperform models using electronic health record data alone. METHODS: The All of Us dataset was used to identify adults between 18 and 70 ys old with weight measurements 2 y apart between 2008 and 2022. Patients with a history of cancer, bariatric surgery, or pregnancy were excluded. Demographics, vital signs, laboratory results, comorbidities, and survey data (Alcohol Use Disorder Identification Test, Patient-Reported Outcomes Measurement Information System physical and mental health scores) were included as model parameters. Elastic net and XGBoost machine learning models were developed with and without survey data to predict >/=10% total body weight gain within 2 y. The data were split into a training sample (60%) and a testing sample (40%), and parameters were tuned using 10-fold cross-validation. Performance was compared using area under the receiver operating characteristic curves (AUCs). RESULTS: Our cohort consisted of 34,715 patients (mean [SD] age 50.9 [13.4] y; 45.7% White; 55.3% female). Over a 2-y span, 10.4% of the cohort gained >/=10% total body weight. AUCs were 0.677 [95% DeLong confidence interval 0.665-0.688] for elastic net and 0.706 [0.695-0.717] for XGBoost. Incorporation of survey data did not improve predictability, with AUCs of 0.681 [0.669-0.692] and 0.705 [0.694-0.716], respectively. CONCLUSIONS: Our machine learning weight gain prediction models had modest performance that was not improved by survey data. The addition of other All of Us variables, including genomic data, may be informative in future studies. CI - Published by Elsevier Inc. FAU - Jawara, Dawda AU - Jawara D AD - Department of Surgery, University of Wisconsin, Madison, Wisconsin. FAU - Lauer, Kate V AU - Lauer KV AD - Department of Surgery, University of Wisconsin, Madison, Wisconsin. FAU - Venkatesh, Manasa AU - Venkatesh M AD - Department of Surgery, University of Wisconsin, Madison, Wisconsin. FAU - Stalter, Lily N AU - Stalter LN AD - Department of Surgery, University of Wisconsin, Madison, Wisconsin. FAU - Hanlon, Bret AU - Hanlon B AD - Department of Surgery, University of Wisconsin, Madison, Wisconsin; Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wisconsin. FAU - Churpek, Matthew M AU - Churpek MM AD - Department of Medicine, University of Wisconsin, Madison, Wisconsin. FAU - Funk, Luke M AU - Funk LM AD - Department of Surgery, University of Wisconsin, Madison, Wisconsin; Department of Surgery, William S. Middleton Memorial VA, Madison, Wisconsin. Electronic address: funk@surgery.wisc.edu. LA - eng GR - R01 DA015060/DA/NIDA NIH HHS/United States GR - T32 DK007665/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Observational Study PT - Research Support, N.I.H., Extramural DEP - 20241231 PL - United States TA - J Surg Res JT - The Journal of surgical research JID - 0376340 SB - IM MH - Humans MH - *Machine Learning MH - *Weight Gain MH - Female MH - Adult MH - Middle Aged MH - Male MH - United States/epidemiology MH - Aged MH - Young Adult MH - *Obesity/diagnosis/epidemiology MH - Electronic Health Records/statistics & numerical data MH - Adolescent MH - Body Mass Index PMC - PMC11911080 MID - NIHMS2045419 OTO - NOTNLM OT - Adult OT - All of us OT - Machine learning OT - Models OT - Obesity OT - Prediction OT - Weight gain EDAT- 2025/01/02 00:21 MHDA- 2025/03/17 00:42 PMCR- 2026/02/01 CRDT- 2025/01/01 18:49 PHST- 2024/09/16 00:00 [received] PHST- 2024/10/31 00:00 [revised] PHST- 2024/11/21 00:00 [accepted] PHST- 2025/03/17 00:42 [medline] PHST- 2025/01/02 00:21 [pubmed] PHST- 2025/01/01 18:49 [entrez] PHST- 2026/02/01 00:00 [pmc-release] AID - S0022-4804(24)00787-X [pii] AID - 10.1016/j.jss.2024.11.042 [doi] PST - ppublish SO - J Surg Res. 2025 Feb;306:43-53. doi: 10.1016/j.jss.2024.11.042. Epub 2024 Dec 31. PMID- 39742551 OWN - NLM STAT- MEDLINE DCOM- 20250302 LR - 20250520 IS - 1873-6807 (Electronic) IS - 1740-1445 (Linking) VI - 52 DP - 2025 Mar TI - Body understanding measure for pregnancy scale (BUMPS): Psychometric properties and predictive validity with postpartum anxiety, depression and body appreciation among Italian peripartum women. PG - 101847 LID - S1740-1445(24)00169-4 [pii] LID - 10.1016/j.bodyim.2024.101847 [doi] AB - Pregnancy is a unique phase in a woman's life marked by profound physical transformations, including changes in body shape and weight. The Body Understanding Measure for Pregnancy Scale (BUMPs) was designed to assess body image during pregnancy. Despite its increasing use, the scale has not yet been adapted into Italian, and evidence regarding its predictive validity with respect to anxiety, depression, and body appreciation is lacking. This study aimed to address these gaps to validate the Italian BUMPs and test its predictive validity. A community sample of 726 Italian pregnant women was recruited (age range 18-48, M(age)= 31.3 +/- 4.79). Participants completed a translated BUMPs and other self-report questionnaires assessing anxiety, depression, and body appreciation. Confirmatory factor analysis supported a three-factor structure for the BUMPs, with dimensions assessing Satisfaction with Appearing Pregnant, Weight Gain Concerns, and Physical Burdens of Pregnancy. BUMPs subscales demonstrated satisfactory internal consistency (omega = 0.765-0.866). Cross-sectional analysis revealed that BUMPs scores correlated with anxiety (r range from 0.25 to 0.32), depression (r range from 0.31 to 0.34), and gestational body mass index (r range from 0.18 to 0.37). Longitudinal analysis associated BUMPs with anxiety, depression, and body appreciation measured after childbirth, providing evidence of predictive validity. Overall, the present study supports the BUMPs as a valid and reliable tool for assessing body image during pregnancy within the Italian context. Additionally, it provides the first evidence of the BUMPs' predictive validity for postpartum mental health outcomes and body appreciation after childbirth. CI - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Grano, C AU - Grano C AD - Department of Psychology, Sapienza University of Rome, Roma, Italy. Electronic address: caterina.grano@uniroma1.it. FAU - Zagaria, A AU - Zagaria A AD - Department of Psychology, Sapienza University of Rome, Roma, Italy; Department of Systems Medicine, Tor Vergata University of Rome, Rome, Italy. FAU - Spinoni, M AU - Spinoni M AD - Department of Psychology, Sapienza University of Rome, Roma, Italy. FAU - Singh Solorzano, C AU - Singh Solorzano C AD - Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. FAU - Cazzato, V AU - Cazzato V AD - School of Psychology, Faculty of Health, Liverpool John Moores University, Liverpool, UK; Department of Cognitive Sciences, Psychology, Education and Cultural Studies, University of Messina, Messina, Italy. FAU - Kirk, E AU - Kirk E AD - School of Psychology, Sport and Sensory Sciences Anglia Ruskin University, Cambridge, UK. FAU - Preston, C AU - Preston C AD - Department of Psychology, University of York, Heslington, York, UK. LA - eng PT - Journal Article DEP - 20241231 PL - Netherlands TA - Body Image JT - Body image JID - 101222431 SB - IM MH - Humans MH - Female MH - Adult MH - Pregnancy MH - Italy MH - Psychometrics MH - *Body Image/psychology MH - Adolescent MH - *Anxiety/psychology/diagnosis MH - Young Adult MH - Reproducibility of Results MH - *Depression, Postpartum/psychology/diagnosis MH - Surveys and Questionnaires/standards MH - Middle Aged MH - Cross-Sectional Studies MH - *Depression/psychology MH - *Peripartum Period/psychology MH - *Pregnant People/psychology OTO - NOTNLM OT - Anxiety OT - Body appreciation OT - Body satisfaction OT - Depression OT - Perinatal mental health OT - Pregnancy OT - Psychometric properties COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/01/02 00:21 MHDA- 2025/03/03 00:56 CRDT- 2025/01/01 18:46 PHST- 2024/07/25 00:00 [received] PHST- 2024/12/06 00:00 [revised] PHST- 2024/12/20 00:00 [accepted] PHST- 2025/03/03 00:56 [medline] PHST- 2025/01/02 00:21 [pubmed] PHST- 2025/01/01 18:46 [entrez] AID - S1740-1445(24)00169-4 [pii] AID - 10.1016/j.bodyim.2024.101847 [doi] PST - ppublish SO - Body Image. 2025 Mar;52:101847. doi: 10.1016/j.bodyim.2024.101847. Epub 2024 Dec 31. PMID- 41777913 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260304 LR - 20260813 IS - 2008-2258 (Print) IS - 2008-4234 (Electronic) IS - 2008-2258 (Linking) VI - 18 IP - 4 DP - 2025 TI - Prognostic nutritional index and systemic inflammation index as predictors of cirrhosis severity: a cross-sectional study. PG - 418-425 LID - 10.22037/ghfbb.v18i4.3195 [doi] AB - AIM: We assessed whether the Prognostic Nutritional Index (PNI) and the Systemic Inflammation Index (SII) are associated with cirrhosis severity and decompensation. BACKGROUND: Cirrhosis severity is routinely staged with MELD and Child-Pugh scores, which only partially capture nutritional and inflammatory status. METHODS: We conducted a cross-sectional study of 202 cirrhotic adults at Shahid Beheshti University hospitals (2018-2022). Demographic, clinical, and lab data were obtained from records. PNI (10 x albumin + 0.005 x lymphocytes) and SII (platelets x neutrophils / lymphocytes) were calculated. Associations with MELD, Child-Pugh, and complications were analyzed (alpha = 0.05; SPSS). RESULTS: Higher SII was associated with greater disease severity, including higher MELD (P = 0.040) and higher Child-Pugh class (overall P = 0.010), with SII levels higher in Child-Pugh class C than in class B (P = 0.001). PNI showed an inverse relationship with MELD, consistent with better nutritional status at lower severity. PNI was higher in patients without ascites (P = 0.020). Both indices differed in patients with hepatic encephalopathy versus those without (P = 0.010). Moreover, SII did not differ across variceal grades (P = 0.891), whereas PNI was lower in higher grades (overall P = 0.005). CONCLUSION: PNI and SII exhibit significant associations with established severity measures in cirrhosis. These indices may complement MELD and Child-Pugh by integrating nutritional and inflammatory information into routine assessment. Prospective, externally validated studies are warranted to determine predictive utility and clinical impact. CI - (c) 2025, Gastroenterology and Hepatology From Bed to Bench (GHFBB). FAU - Hatami, Behzad AU - Hatami B AD - Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Ghanbarpour, Omid AU - Ghanbarpour O AD - Internal Medicine Department, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Pasharavesh, Leila AU - Pasharavesh L AD - Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Rabani, Amir Hassan AU - Rabani AH AD - Department of Transplant & Hepatobiliary Surgery, Taleghani hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Alirezaei, Toktam AU - Alirezaei T AD - Research Center of Artificial Intelligence in Health, Shohada-e Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Geshani, Zahra AU - Geshani Z AD - Student Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Kalami, Sahar AU - Kalami S AD - Faculty of Medical Basic Sciences, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran. FAU - Jafary, Hosein AU - Jafary H AD - Student Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. LA - eng PT - Journal Article DEP - 20251213 PL - Iran TA - Gastroenterol Hepatol Bed Bench JT - Gastroenterology and hepatology from bed to bench JID - 101525875 PMC - PMC12920691 OTO - NOTNLM OT - Ascites OT - Esophageal varices OT - Inflammation OT - Liver cirrhosis OT - Nutritional status OT - Predictive value of tests OT - Prognosis OT - Severity of illness index COIS- There is no conflict of interest for authors of this article. EDAT- 2025/01/01 00:00 MHDA- 2025/01/01 00:01 PMCR- 2025/01/01 CRDT- 2026/03/04 04:32 PHST- 2025/08/17 00:00 [received] PHST- 2025/11/09 00:00 [accepted] PHST- 2025/01/01 00:01 [medline] PHST- 2025/01/01 00:00 [pubmed] PHST- 2026/03/04 04:32 [entrez] PHST- 2025/01/01 00:00 [pmc-release] AID - 10.22037/ghfbb.v18i4.3195 [doi] PST - ppublish SO - Gastroenterol Hepatol Bed Bench. 2025;18(4):418-425. doi: 10.22037/ghfbb.v18i4.3195. Epub 2025 Dec 13. PMID- 39742163 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250104 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 16 IP - 12 DP - 2024 Dec TI - Lifestyle Factors Associated With Childhood Obesity in South Asian Expatriates of Dubai: A Cross-Sectional Study. PG - e74924 LID - 10.7759/cureus.74924 [doi] LID - e74924 AB - Background Obesity, a chronic disease caused by excessive fat deposits, increases the risk of various health conditions. Childhood obesity is a growing global concern, affecting millions of children. There is a paucity of research on the determinants of childhood obesity in the expatriate population of Dubai. This study aimed to explore modifiable key lifestyle factors contributing to childhood obesity in Dubai's South Asian expatriates. Methodology Based on prior research, we decided to evaluate the role of three most commonly associated lifestyle factors: physical activity, fast food consumption, and daily screen time. The hypothesis was that higher screen time and fast food intake would positively correlate with body mass index (BMI), while physical activity would show a negative correlation. The study applied a non-probability convenience sampling method and included 208 South Asian children aged 5-17 who visited a Dubai clinic between January and March 2024 and who did not have any serious physical or mental health illness requiring long-term medication or any genetic disorder. Results Results showed that one-third of the children had a BMI of >/=85 percentile with no significant gender differences. Age was positively correlated with BMI percentile. Higher daily screen time is significantly associated with a higher prevalence of overweight and obesity as per the Centers for Disease Control and Prevention (CDC), International Obesity Task Force (IOTF), and World Health Organization (WHO) classifications. The frequent intake of fast food is associated with a higher prevalence of overweight and obesity only as per the IOTF classification. Physical activity, however, was not significantly different between the two groups. Conclusion We concluded that children who have a BMI of >/=85 percentile tend to have significantly higher daily screen time. The association between frequent fast food consumption and higher BMI was significant only under the IOTF criteria. Larger multicentric studies are needed to further validate these associations and to look for causal relationships. Nevertheless, this study underscores modifiable risk factors for childhood obesity, suggesting that small lifestyle changes could mitigate this epidemic. CI - Copyright (c) 2024, Pandey et al. FAU - Pandey, Spriha AU - Pandey S AD - Basic Sciences, GEMS Modern Academy, Dubai, ARE. FAU - Agarwal, Meenu AU - Agarwal M AD - Pediatrics, Aster Jubilee Medical Center, Dubai, ARE. LA - eng PT - Journal Article DEP - 20241201 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC11687951 OTO - NOTNLM OT - cross-sectional studies OT - expatriates OT - lifestyle factors OT - obesity and overweight OT - school children COIS- Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. The Institutional Review Board and Ethics Committee of Aster Jubilee Medical Center issued approval AJMC/MOM/EC/23/026. The Institutional Review Board and Ethics Committee of Aster Jubilee Medical Center discussed and reviewed the proposal for a cross-sectional study titled "Lifestyle Factors associated with Childhood Obesity in South Asian Expatriates of Dubai: A Cross-sectional Analytical Study" on 18 December 2023. We understand that this study is just an observational study and informed consent would be taken from parents of each child participating in this study. Hence, it does not pose any risk to the children involved. We are obligated to protect the children's privacy. Thus, the institutional review board approves the research proposal without any objection. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2025/01/01 21:25 MHDA- 2025/01/01 21:26 PMCR- 2024/12/01 CRDT- 2025/01/01 04:36 PHST- 2024/11/30 00:00 [accepted] PHST- 2025/01/01 21:26 [medline] PHST- 2025/01/01 21:25 [pubmed] PHST- 2025/01/01 04:36 [entrez] PHST- 2024/12/01 00:00 [pmc-release] AID - 10.7759/cureus.74924 [doi] PST - epublish SO - Cureus. 2024 Dec 1;16(12):e74924. doi: 10.7759/cureus.74924. eCollection 2024 Dec. PMID- 39742124 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250104 IS - 2008-7802 (Print) IS - 2008-8213 (Electronic) IS - 2008-7802 (Linking) VI - 15 DP - 2024 TI - Association Between Different Dietary Carbohydrate and Risk of Depression, Anxiety, and Stress Among Female Adolescents. PG - 71 LID - 10.4103/ijpvm.ijpvm_291_23 [doi] LID - 71 AB - PURPOSE: Mental disorders account for a large part of the burden of disease in young population. The present study aimed to investigate the relationship between carbohydrate intakes and the risk of depression, anxiety, and stress among female adolescents. METHODS: In this cross-sectional study, 263 female adolescents aged 15-18 years participated. Depression, anxiety, and stress scores were determined by DASS-21 (Depression Anxiety Stress Score-21 items) questionnaire, and dietary intakes were assessed using a validated 168-item food frequency questionnaire. Crude and multivariable-adjusted odds ratios (OR) and 95% confidence intervals (CIs) were estimated through logistic regression analysis. RESULTS: Adolescents with depression consumed more glucose and sucrose and less lactose compared to adolescents without depression. After adjustment for all confounders, higher intakes of glucose and sucrose were significantly associated with increased risk of depression (OR (glu) = 1.3, P = 0.035 and OR (suc) = 1.41, P = 0.034), anxiety (OR (glu) = 1.3, P = 0.019 and OR (suc) = 1.81, P = 0.027), and stress (OR (glu) = 1.41, P = 0.046 and OR (suc) = 1.8, P = 0.044). In addition, increasing lactose intake was significantly associated with reducing the risk of depression (OR = 0.96, P = 0.013) and stress (OR = 0.96, P = 0.015). CONCLUSIONS: This study found significant associations between dietary carbohydrate intake and mental disorders among female adolescent. CI - Copyright: (c) 2024 International Journal of Preventive Medicine. FAU - Naghshi, Niayesh AU - Naghshi N AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Tehrani, Asal N AU - Tehrani AN AD - Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. AD - Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. FAU - Rabiei, Samira AU - Rabiei S AD - Department of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Behrouz, Vahideh AU - Behrouz V AD - Department of Nutrition, Faculty of Public Health, Kerman University of Medical Sciences, Kerman, Iran. FAU - Yari, Zahra AU - Yari Z AD - Department of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. LA - eng PT - Journal Article DEP - 20241223 PL - Iran TA - Int J Prev Med JT - International journal of preventive medicine JID - 101535380 PMC - PMC11687680 OTO - NOTNLM OT - Anxiety OT - carbohydrate OT - depression OT - diet OT - stress COIS- There are no conflicts of interest. EDAT- 2025/01/01 21:25 MHDA- 2025/01/01 21:26 PMCR- 2024/12/23 CRDT- 2025/01/01 04:35 PHST- 2023/10/28 00:00 [received] PHST- 2024/06/04 00:00 [accepted] PHST- 2025/01/01 21:26 [medline] PHST- 2025/01/01 21:25 [pubmed] PHST- 2025/01/01 04:35 [entrez] PHST- 2024/12/23 00:00 [pmc-release] AID - IJPVM-15-71 [pii] AID - 10.4103/ijpvm.ijpvm_291_23 [doi] PST - epublish SO - Int J Prev Med. 2024 Dec 23;15:71. doi: 10.4103/ijpvm.ijpvm_291_23. eCollection 2024. PMID- 39738317 OWN - NLM STAT- MEDLINE DCOM- 20241231 LR - 20250324 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Dec 30 TI - Association between coffee and caffeine intake and functional dyspepsia. PG - 31690 LID - 10.1038/s41598-024-81670-x [doi] LID - 31690 AB - No previous study has examined the association between coffee and caffeine intake and odds of functional dyspepsia (FD). The aim of this study was to investigate the association between coffee and caffeine intake and odds of FD and its components in a large sample of Iranian adults. In this cross-sectional study on 3362 adults aged 18-55 years, a validated food frequency questionnaire (DS-FFQ) was used to assess dietary intakes. A validated modified Persian version of the Rome III questionnaire was used for assessment of FD. Logistic regression was applied to compute odds ratios for FD and its components considering a wide range of covariates. Mean age of study population was 36.2 +/- 7.8 years, of them 58.3% were females. The prevalence of FD among study participants was 14.5%. The prevalence of post-prandial fullness, early satiation, and epigastric pain was 7.6, 5.8, and 7.6%, respectively. After controlling for potential confounders, no significant association was observed between coffee (OR: 1.27; 95% CI: 0.86-1.87), and caffeine (OR: 1.00; 95% CI: 0.99-1.02) consumption and odds of FD. In addition, coffee and caffeine consumption was not significantly associated with odds of FD symptoms such as early satiation, post-prandial fullness, and epigastric pain. This was also the case when the analysis was done stratified by gender and BMI status. In conclusion, we found no significant association between coffee and caffeine consumption with odds of FD and its symptoms. Further research in other populations with high coffee consumption is needed. CI - (c) 2024. The Author(s). FAU - Koochakpoor, Glareh AU - Koochakpoor G AD - Maragheh University of Medical Sciences, Maragheh, Iran. FAU - Salari-Moghaddam, Asma AU - Salari-Moghaddam A AD - Health and Environment Research Center, Ilam University of Medical Sciences, Ilam, Iran. AD - Department of Biochemistry, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran. FAU - Keshteli, Ammar Hassanzadeh AU - Keshteli AH AD - Department of Medicine, University of Alberta, Edmonton, AB, Canada. AD - Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Esmaillzadeh, Ahmad AU - Esmaillzadeh A AD - Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. a.esmaillzadeh@gmail.com. AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O. Box 14155-6117, Tehran, Iran. a.esmaillzadeh@gmail.com. AD - Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. a.esmaillzadeh@gmail.com. FAU - Adibi, Peyman AU - Adibi P AD - Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. LA - eng PT - Journal Article DEP - 20241230 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Coffee) RN - 3G6A5W338E (Caffeine) SB - IM MH - Humans MH - *Coffee MH - *Caffeine/administration & dosage/adverse effects MH - *Dyspepsia/epidemiology MH - Female MH - Adult MH - Male MH - Middle Aged MH - Cross-Sectional Studies MH - Adolescent MH - Young Adult MH - Iran/epidemiology MH - Surveys and Questionnaires MH - Prevalence MH - Odds Ratio PMC - PMC11686396 OTO - NOTNLM OT - Caffeine OT - Coffee OT - Functional dyspepsia COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval and consent participants: The study protocol was ethically approved by the Regional Bioethics Committee of Isfahan University of Medical Sciences. All participants provided written informed consent forms. All methods were carried out in accordance with relevant guideline and regulations. EDAT- 2025/01/01 12:42 MHDA- 2025/01/01 12:43 PMCR- 2024/12/30 CRDT- 2024/12/31 12:01 PHST- 2023/12/07 00:00 [received] PHST- 2024/11/28 00:00 [accepted] PHST- 2025/01/01 12:43 [medline] PHST- 2025/01/01 12:42 [pubmed] PHST- 2024/12/31 12:01 [entrez] PHST- 2024/12/30 00:00 [pmc-release] AID - 10.1038/s41598-024-81670-x [pii] AID - 81670 [pii] AID - 10.1038/s41598-024-81670-x [doi] PST - epublish SO - Sci Rep. 2024 Dec 30;14(1):31690. doi: 10.1038/s41598-024-81670-x. PMID- 39736636 OWN - NLM STAT- MEDLINE DCOM- 20241231 LR - 20260701 IS - 1472-6947 (Electronic) IS - 1472-6947 (Linking) VI - 24 IP - 1 DP - 2024 Dec 30 TI - Determining the minimum data elements to develop a child malnutrition registry system. PG - 411 LID - 10.1186/s12911-024-02771-1 [doi] LID - 411 AB - BACKGROUND: Today, malnutrition is one of the biggest health crises for children in the world. Access to accurate and high-quality data is very important to establish policies to deal with it. Registries are considered valuable tools for data collection and management of child malnutrition. Designing a dataset is the first step toward developing a registry system. OBJECTIVE: This study aimed to determine the minimum data elements for the Child Malnutrition Registry System (CMRS). METHODS: In this descriptive and cross-sectional study, firstly, data elements were extracted from reviewing scientific papers, reviewing existing systems, and conducting interviews with experts. Then, the extracted data elements were validated using an expert panel and Delphi technique. The criterion for accepting the final data elements in the registry system was based on a collective agreement, and it was when 75% of the experts collectively agreed upon a particular data element. RESULTS: A dataset was designed using the determined minimum data elements, including administrative data elements with three sub-categories (demographic, socioeconomic, and healthcare providers) and clinical data elements with 11 sub-categories (medical history, anthropometric indicators, clinical examination, nutritional data, physical activity and sleep, lab tests, para-clinical tests, diagnosis, complications, care procedures, life status, and follow-up). The number of final data elements in administrative and clinical categories were 47 and 251, respectively. CONCLUSION: A comprehensive and accurate dataset provides conceptual structures that are the basis for developing the children's malnutrition registry system. The result of this study can fill the existing gaps in collecting, storing, and analyzing child malnutrition data. Furthermore, it can play an effective role in creating a successful strategic plan for improving child malnutrition. CI - (c) 2024. The Author(s). FAU - Sadeghi, Malihe AU - Sadeghi M AD - Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran. sadeghiii.m@gmail.com. AD - Department of Health Information Technology, School of Allied Medical Sciences, Semnan University of Medical Sciences, Semnan, Iran. sadeghiii.m@gmail.com. FAU - Langarizadeh, Mostafa AU - Langarizadeh M AD - Department of Health Information Management, School of Health Management and Information Sciences , Iran University of Medical Sciences, Tehran, Iran. langarizade.m@iums.ac.ir. FAU - Olang, Beheshteh AU - Olang B AD - Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran. beheshteholang@gmail.com. FAU - Sayadi, Mohammadjavad AU - Sayadi M AD - Department of Computer Engineering, National University of Skills, Tehran, Iran. FAU - Sheikhtaheri, Abbas AU - Sheikhtaheri A AD - Department of Health Information Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran. LA - eng PT - Journal Article DEP - 20241230 PL - England TA - BMC Med Inform Decis Mak JT - BMC medical informatics and decision making JID - 101088682 SB - IM MH - Humans MH - *Registries/standards MH - Cross-Sectional Studies MH - *Child Nutrition Disorders/epidemiology MH - Child MH - Delphi Technique MH - Child, Preschool MH - Common Data Elements PMC - PMC11684282 OTO - NOTNLM OT - Children OT - Dataset OT - Delphi technique OT - Malnutrition OT - Registry system COIS- Declarations. Ethics approval and consent to participate: Ethical approval for the study was obtained from the Ethical Committee of Iran University of Medical Sciences (IR.IUMS.REC.1397.1083). All methods were carried out in accordance with relevant guidelines and regulations. Informed consent was obtained from all participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2024/12/31 00:19 MHDA- 2024/12/31 11:04 PMCR- 2024/12/30 CRDT- 2024/12/30 23:52 PHST- 2023/11/21 00:00 [received] PHST- 2024/11/18 00:00 [accepted] PHST- 2024/12/31 11:04 [medline] PHST- 2024/12/31 00:19 [pubmed] PHST- 2024/12/30 23:52 [entrez] PHST- 2024/12/30 00:00 [pmc-release] AID - 10.1186/s12911-024-02771-1 [pii] AID - 2771 [pii] AID - 10.1186/s12911-024-02771-1 [doi] PST - epublish SO - BMC Med Inform Decis Mak. 2024 Dec 30;24(1):411. doi: 10.1186/s12911-024-02771-1. PMID- 39734344 OWN - NLM STAT- MEDLINE DCOM- 20241230 LR - 20250104 IS - 1303-6165 (Electronic) IS - 1300-0144 (Print) IS - 1300-0144 (Linking) VI - 54 IP - 6 DP - 2024 TI - Reliability and validity of the Turkish version of the Infant Motor Activity Log in infants with upper extremity functional asymmetry: how often and how well? PG - 1271-1280 LID - 10.55730/1300-0144.5909 [doi] AB - BACKGROUND/AIM: Functional asymmetry in the upper extremities may occur in infants with neuromotor problems due to neurodevelopmental or musculoskeletal disorders. The aim of this study was to investigate the validity and reliability of the Turkish version of the Infant Motor Activity Log (IMAL-T), which assesses the frequency (how often) and quality (how well) of the affected arm usage during activities in infants with functional asymmetry in the upper extremities. MATERIALS AND METHODS: The IMAL-T was administered face-to-face to the parents of 102 infants [60 infants at high risk of developing cerebral palsy (CP) and 42 infants with brachial plexus birth injury (BPBI)], aged 6-24 months, with functional asymmetry in the upper extremities. One week later, the IMAL-T was administered again to 22 parents to determine the test-retest reliability. Cronbach's alpha and the intraclass correlation coefficient (ICC) were used to determine the internal consistency and test-retest reliability. Discriminant validity was assessed using the manual ability level (Mini Manual Ability Classification System) and the nerve injury type was evaluated using the independent samples t test. For concurrent validity, the relationship between the IMAL-T and the Pediatric Evaluation of Disability Inventory (PEDI) self-care was examined using Spearman's correlation coefficient. RESULTS: Internal consistency (Cronbach's alpha >/= 0.91) and test-retest reliability (ICC >/= 0.93) of the IMAL-T were adequate. The IMAL-T scores differed according to the mini-MACS and nerve injury type (p < 0.05). Moderate to strong (CP, r >/= 0.706, p < 0.001; BPBI, r >/= 0.579, p < 0.001) correlation coefficients were found between the IMAL-T and PEDI self-care scores. CONCLUSION: The IMAL-T is a reliable and valid parent-reported outcome measure that indicates the frequency and quality of the affected arm use during age-appropriate real-life activity in infants aged 6-24 months with upper extremity functional asymmetry due to neuromotor problems. The IMAL-T can be used in early intervention to assess upper extremity functional asymmetry in Turkish infants. CI - (c) TUBITAK. FAU - Seyhan Biyik, Kubra AU - Seyhan Biyik K AUID- ORCID: 0000-0001-7943-4255 AD - Cerebral Palsy and Pediatric Rehabilitation Unit, Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkiye. FAU - Ozal, Cemil AU - Ozal C AUID- ORCID: 0000-0001-5692-3814 AD - Cerebral Palsy and Pediatric Rehabilitation Unit, Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkiye. FAU - Delioglu, Kivanc AU - Delioglu K AUID- ORCID: 0000-0001-5898-3685 AD - Cerebral Palsy and Pediatric Rehabilitation Unit, Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkiye. FAU - Kerem Gunel, Mintaze AU - Kerem Gunel M AUID- ORCID: 0000-0003-4942-5272 AD - Cerebral Palsy and Pediatric Rehabilitation Unit, Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkiye. LA - eng PT - Journal Article PT - Validation Study DEP - 20241011 PL - Turkey TA - Turk J Med Sci JT - Turkish journal of medical sciences JID - 9441758 SB - IM MH - Humans MH - Infant MH - Reproducibility of Results MH - Female MH - Male MH - *Upper Extremity/physiopathology MH - Turkey MH - *Cerebral Palsy/physiopathology MH - Motor Activity/physiology MH - Child, Preschool MH - Disability Evaluation MH - Birth Injuries/physiopathology MH - Surveys and Questionnaires/standards PMC - PMC11673628 OTO - NOTNLM OT - Asymmetry OT - brachial plexus OT - cerebral palsy OT - infant OT - upper extremity COIS- Conflict of interest: The authors declare that they have no conflicts of interest related to this paper. This study did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. EDAT- 2024/12/30 06:18 MHDA- 2024/12/30 06:19 PMCR- 2024/10/11 CRDT- 2024/12/30 05:14 PHST- 2024/05/03 00:00 [received] PHST- 2024/12/05 00:00 [revised] PHST- 2024/10/11 00:00 [accepted] PHST- 2024/12/30 06:19 [medline] PHST- 2024/12/30 06:18 [pubmed] PHST- 2024/12/30 05:14 [entrez] PHST- 2024/10/11 00:00 [pmc-release] AID - tjmed-54-06-1271 [pii] AID - 10.55730/1300-0144.5909 [doi] PST - epublish SO - Turk J Med Sci. 2024 Oct 11;54(6):1271-1280. doi: 10.55730/1300-0144.5909. eCollection 2024. PMID- 39733654 OWN - NLM STAT- MEDLINE DCOM- 20250429 LR - 20250728 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 131 DP - 2025 Mar TI - Relationship between dietary diversity, eating behavior, and cognitive performance in economically disadvantaged school children. PG - 112658 LID - S0899-9007(24)00307-1 [pii] LID - 10.1016/j.nut.2024.112658 [doi] AB - OBJECTIVE: The effect of dietary diversity and eating behavior on attention, and concentration among children lacking in resources is unclear. We aim to investigate the association between dietary diversity, eating behavior, and cognitive abilities among economically disadvantaged children at high risk of cognitive impairment. METHODS: This study enrolled 676 children aged 10-12 years from 16 free academic tutoring centers across Taiwan. Demographic and dietary behavior data were collected through self-administered questionnaires. Cognitive abilities, specifically attention and concentration, were assessed using the following validated tools: The Attention Test for Elementary School Children and the Concentration Questionnaire. RESULTS: Those who reported poor concentration and attention tend to have a higher prevalence of obesity. After adjustment for confounding variables by general linear model, a significant positive correlation was identified between dietary diversity score (DDS) and classroom concentration score (regression coefficient (beta) = 0.24; P < 0.0001). Conversely, the frequency of unhealthy food intake exhibited a negative correlation with concentration (beta: -0.09; P = 0.025). Moreover, a negative correlation was observed between the frequency of instant food intake and the attention (beta: -0.08; P = 0.04) and concentration scores (beta: -0.09; P = 0.026). CONCLUSIONS: Enhancing dietary diversity and reducing unfavorable food intake may improve cognitive performance in socioeconomically disadvantaged children. CI - Copyright (c) 2024 Elsevier Inc. All rights reserved. FAU - Yeh, Chiu-Wen AU - Yeh CW AD - Department of Nutrition, China Medical University, Taichung, Taiwan. FAU - Lee, Meei-Shuyuan AU - Lee MS AD - Department of Public Health, National Defense Medical Center, Taipei, Taiwan. FAU - Lo, Yuan-Ting C AU - Lo YC AD - Department of Public Health, National Defense Medical Center, Taipei, Taiwan. FAU - Chen, Yi-Chieh AU - Chen YC AD - Department of Nutrition, China Medical University, Taichung, Taiwan; Department of Nutrition, Chang Bing Show Chwan Memorial Hospital, Lukang Zhen, Changhwa County, Taiwan. FAU - Chen, Wei-Chih AU - Chen WC AD - Boyo Social Welfare Foundation, Puli Township, Nantou County, Taiwan. FAU - Huang, Yi-Chen AU - Huang YC AD - Department of Nutrition, China Medical University, Taichung, Taiwan. Electronic address: yichenhuang@mail.cmu.edu.tw. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241203 PL - United States TA - Nutrition JT - Nutrition (Burbank, Los Angeles County, Calif.) JID - 8802712 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - *Feeding Behavior/psychology MH - *Diet/statistics & numerical data/psychology MH - *Cognition/physiology MH - Taiwan/epidemiology MH - *Vulnerable Populations/psychology/statistics & numerical data MH - Attention MH - Surveys and Questionnaires MH - *Poverty MH - Cross-Sectional Studies MH - Schools MH - Pediatric Obesity/epidemiology OTO - NOTNLM OT - Attention OT - Concentration OT - Dietary diversity OT - Eating behavior OT - Socioeconomically disadvantage children COIS- Declaration of competing interest The authors declare the following potential competing financial interests: YCH (corresponding author) reports financial support from the Boyo Social Welfare Foundation. WCC is employed by the Boyo Social Welfare Foundation. All other authors declare no conflicts of interest that could influence the work reported in this paper. EDAT- 2024/12/30 00:19 MHDA- 2025/02/23 00:42 CRDT- 2024/12/29 18:06 PHST- 2024/07/30 00:00 [received] PHST- 2024/11/21 00:00 [revised] PHST- 2024/11/25 00:00 [accepted] PHST- 2025/02/23 00:42 [medline] PHST- 2024/12/30 00:19 [pubmed] PHST- 2024/12/29 18:06 [entrez] AID - S0899-9007(24)00307-1 [pii] AID - 10.1016/j.nut.2024.112658 [doi] PST - ppublish SO - Nutrition. 2025 Mar;131:112658. doi: 10.1016/j.nut.2024.112658. Epub 2024 Dec 3. PMID- 39730903 OWN - NLM STAT- MEDLINE DCOM- 20241228 LR - 20260807 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Dec 28 TI - RETRACTED ARTICLE: Fusion of transfer learning with nature-inspired dandelion algorithm for autism spectrum disorder detection and classification using facial features. PG - 31104 LID - 10.1038/s41598-024-82299-6 [doi] LID - 31104 AB - Autism spectrum disorder (ASD) is a neurologic disorder considered to cause discrepancies in physical activities, social skills, and cognition. There is no specific medicine for treating this disorder; early intervention is critical to improving brain function. Additionally, the lack of a clinical test for detecting ASD makes diagnosis challenging. To regulate identification, physicians entertain the children's activities and growing histories. The human face is employed as a biological signature as it has the potential reflections of the brain. It is utilized as a simpler and more helpful tool for early detection. Artificial intelligence (AI) algorithms in medicinal rehabilitation and diagnosis can help specialists identify various illnesses more successfully. However, owing to its particular heterogeneous symptoms and complex nature, diagnosis of ASD remains to be challenging for investigators. This work presents a Fusion of Transfer Learning (TL) with the Dandelion Algorithm for Accurate Autism Spectrum Disorder Detection and Classification (FTLDA-AASDDC) method. The FTLDA-AASDDC technique detects and classifies autism and non-autism samples using facial images. To accomplish this, the FTLDA-AASDDC technique utilizes a bilateral filter (BF) approach for noise elimination. Next, the FTLDA-AASDDC technique employs a fusion-based TL process comprising three models, namely MobileNetV2, DenseNet201, and ResNet50. Moreover, the attention-based bi-directional long short-term memory (A-BiLSTM) method is used to classify and recognize ASD. Finally, the Dandelion Algorithm (DA) is employed to optimize the parameter tuning process, improving the efficacy of the A-BiLSTM technique. A wide range of simulation analyses is performed to highlight the ASD classification performance of the FTLDA-AASDDC technique. The experimental validation of the FTLDA-AASDDC technique portrayed a superior accuracy value of 97.50% over existing techniques. CI - (c) 2024. The Author(s). FAU - Elangovan, G AU - Elangovan G AD - Department of Data Science and Business Systems, School of Computing, SRM Institute of Science and Technology, Kattankulathur, Chennai, 603203, India. FAU - Kumar, N Jagadish AU - Kumar NJ AD - Department of Data Science and Business Systems, School of Computing, SRM Institute of Science and Technology, Kattankulathur, Chennai, 603203, India. FAU - Shobana, J AU - Shobana J AD - Department of Data Science and Business Systems, School of Computing, SRM Institute of Science and Technology, Kattankulathur, Chennai, 603203, India. FAU - Ramprasath, M AU - Ramprasath M AD - Department of Data Science and Business Systems, School of Computing, SRM Institute of Science and Technology, Kattankulathur, Chennai, 603203, India. FAU - Joshi, Gyanendra Prasad AU - Joshi GP AD - Department of AI Software, Kangwon National University, Samcheok, 25913, Republic of Korea. joshi@kangwon.ac.kr. FAU - Cho, Woong AU - Cho W AD - Department of Electronics, Information and Communication Engineering, Kangwon National University, Samcheok, 25913, Republic of Korea. wcho@kangwon.ac.kr. LA - eng PT - Journal Article PT - Retracted Publication DEP - 20241228 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM RIN - 10.1038/s41598-024-82299-6 MH - Humans MH - *Autism Spectrum Disorder/diagnosis/classification MH - *Algorithms MH - Face MH - Artificial Intelligence MH - Child MH - Machine Learning PMC - PMC11680803 OTO - NOTNLM OT - Autism spectrum disorder OT - Bilateral filter OT - Dandelion algorithm OT - Facial image OT - Fusion process OT - Transfer learning COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2024/12/28 11:41 MHDA- 2024/12/28 11:42 PMCR- 2024/12/28 CRDT- 2024/12/28 00:10 PHST- 2024/09/22 00:00 [received] PHST- 2024/12/04 00:00 [accepted] PHST- 2024/12/28 11:42 [medline] PHST- 2024/12/28 11:41 [pubmed] PHST- 2024/12/28 00:10 [entrez] PHST- 2024/12/28 00:00 [pmc-release] AID - 10.1038/s41598-024-82299-6 [pii] AID - 82299 [pii] AID - 10.1038/s41598-024-82299-6 [doi] PST - epublish SO - Sci Rep. 2024 Dec 28;14(1):31104. doi: 10.1038/s41598-024-82299-6. PMID- 39730403 OWN - NLM STAT- MEDLINE DCOM- 20241227 LR - 20250104 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Dec 28 TI - Association between volatile organic compounds exposure and infertility risk among American women aged 18-45 years from NHANES 2013-2020. PG - 30711 LID - 10.1038/s41598-024-80277-6 [doi] LID - 30711 AB - The risk of infertility is progressively escalating over the years, and it has been established that exposure to environmental pollutants is closely linked to infertility. As a prevalent environmental pollutant in daily life, there is still a lack of substantial evidence on the association between volatile organic compounds (VOCs) exposure and infertility risk. This study aimed to examine the association between VOCs exposure and the risk of female infertility in the United States. Participant data sets from three cycles (2013-2020) were collected and downloaded from the National Health and Nutrition Examination Survey (NHANES), including demographics, examination, laboratory and questionnaire data. The baseline characteristics of the included population were evaluated, and the weighted quartile logistic regression was used to analyze the association between the urinary metabolites of VOCs (mVOCs) levels and the risk of infertility. Further exploration of the relationship between mVOCs and infertility was conducted by using 35 and 25 as the cut-off points for age and BMI subgroup analyses, respectively. Restricted cubic spline (RCS) was employed to elucidate the nonlinear relationship between mVOCs and infertility risk. Additionally, the Bayesian kernel machine regression (BKMR) model with 20,000 iterations was applied to elucidate the link between mVOCs and the risk of infertility when exposed to mixed or individual mVOCs. A total of 1082 women aged 18 to 45 years were included in this study, with 133 in the infertility group and 949 in the control group. The analysis of baseline characteristics suggested that urinary 34MHA, AMCC and DHBMA levels were significantly higher in the infertility group compared to the control group (p < 0.05). Quartile logistic regression analysis indicated that AAMA (Q3), AMCC (Q4), CYMA (Q3) and HPMMA (Q3) were positively associated with infertility risk in all models (p < 0.05). Subgroup analysis revealed different risk factors for infertility among various subgroups, with CYMA consistently showing a positive correlation with infertility risk in two age subgroups (p < 0.05). Furthermore, the association between mVOCs and infertility was observed only in the subgroup with BMI >/= 25 kg/m(2). RCS analysis indicated that 2MHA, ATCA, BMA, BPMA, CYMA, 2HPMA, 3HPMA and PGA exhibited linear dose-response relationships with infertility (p > 0.05), while the remaining variables showed nonlinear relationships (p < 0.05). The BKMR model demonstrated that the risk of female infertility exhibited an increasing trend with the accumulation of mVOCs co-exposure. A positive association between the exposure to mVOCs represented by 34MHA and AMCC and the risk of infertility was observed in this research. However, the inherent limitations associated with the cross-sectional study design necessitate the pursuit of additional prospective and experimental research to further elucidate and validate the relationships between various mVOCs exposure and female infertility. CI - (c) 2024. The Author(s). FAU - Yang, Qiaorui AU - Yang Q AD - Department of Gynecology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China. AD - Guanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China. FAU - Zhang, Jinfu AU - Zhang J AD - Department of Gynecology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China. AD - Department of Gynecology, Shanghai Guanghua Hospital of Integrative Medicine, Shanghai, China. FAU - Fan, Zhenliang AU - Fan Z AD - Nephrology Department, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Zhejiang, China. fanmlov@sina.cn. AD - Academy of Chinese Medical Science, Zhejiang Chinese Medical University, Zhejiang, China. fanmlov@sina.cn. LA - eng GR - LQ22H270002/Natural Science Foundation of Zhejiang Province,China/ GR - 82104756/National Natural Science Foundation of China/ PT - Journal Article DEP - 20241228 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Volatile Organic Compounds) RN - 0 (Environmental Pollutants) SB - IM MH - Humans MH - Female MH - *Volatile Organic Compounds/urine/adverse effects MH - Adult MH - *Infertility, Female/epidemiology/urine MH - United States/epidemiology MH - Middle Aged MH - Adolescent MH - *Nutrition Surveys MH - Young Adult MH - *Environmental Exposure/adverse effects MH - Risk Factors MH - Environmental Pollutants/urine/adverse effects PMC - PMC11681195 OTO - NOTNLM OT - Infertility OT - Metabolite of volatile organic compounds OT - National Health and Nutrition Examination Survey OT - Volatile organic compounds COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: The NHANES database strictly maintains the confidentiality of the health information it gathers. During the process of informed consent, participants in the survey were given the assurance that the data collected would solely be used for the intended purposes and would not be disclosed or shared with any third party without their consent or the establishment's agreement, as mandated by Sect. 308(d) of the Public Health Service Act (42 U.S.C. 242 m). EDAT- 2024/12/28 11:43 MHDA- 2024/12/28 11:44 PMCR- 2024/12/28 CRDT- 2024/12/27 23:21 PHST- 2024/02/27 00:00 [received] PHST- 2024/11/18 00:00 [accepted] PHST- 2024/12/28 11:44 [medline] PHST- 2024/12/28 11:43 [pubmed] PHST- 2024/12/27 23:21 [entrez] PHST- 2024/12/28 00:00 [pmc-release] AID - 10.1038/s41598-024-80277-6 [pii] AID - 80277 [pii] AID - 10.1038/s41598-024-80277-6 [doi] PST - epublish SO - Sci Rep. 2024 Dec 28;14(1):30711. doi: 10.1038/s41598-024-80277-6. PMID- 39729592 OWN - NLM STAT- MEDLINE DCOM- 20250429 LR - 20260907 IS - 1536-3724 (Electronic) IS - 1050-642X (Linking) VI - 35 IP - 2 DP - 2025 Mar 1 TI - Can Trabecular Bone Score Enhance Fracture Risk Assessment in Long-Distance Runners With Bone Stress Injuries? PG - 127-131 LID - 10.1097/JSM.0000000000001279 [doi] AB - OBJECTIVE: To evaluate the trabecular bone score (TBS) Z scores in long-distance runners with bone stress injuries (BSIs) in whom the bone mineral density (BMD) Z score is more than -1.0 (Aim 1) and whether the number of runners with abnormal TBS Z scores would be higher in those with BSI in trabecular-rich sites as compared with cortical-rich sites (Aim 2). DESIGN: Retrospective cohort study. SETTING: Institutional sports medicine center. PATIENTS: We analyzed Z scores derived from the TBS and BMD in 44 long-distance runners aged 18 to 40 years who had sustained BSIs between 2017 and 2023 and undergone a dual-energy x-ray absorptiometry scan with reported TBS measurements within 1 year before or 2 years after their injuries. INDEPENDENT VARIABLES: Bone mineral density and TBS Z scores. MAIN OUTCOME MEASURES: Evaluation of BMD and TBS Z scores in long-distance runners with BSIs, further stratified according to cortical-rich and trabecular-rich BSIs. RESULTS: Bone mineral density assessments revealed an average Z score of -0.96 +/- 0.99. In this cohort of 44 runners, 55% (n = 24) of runners were reported to have BMD Z score more than -1.0. Within this subgroup, 54% (n = 13) displayed abnormal TBS. Stratifying BSIs by trabecular- (n = 23) and cortical-rich (n = 19) sites, we found no significant difference in sex, mean BMD, or the number of runners with abnormal TBS between the 2 groups. CONCLUSIONS: Trabecular bone score Z scores in sports medicine may provide complementary information to BMD in long-distance runners with BSI, particularly when the BMD Z scores are more than -1.0. However, further research is needed to validate the usefulness of TBS Z scores in this context. STUDY DESIGN: Cohort study. LEVEL OF EVIDENCE: Retrospective Case Series, IV. CI - Copyright (c) 2024 Wolters Kluwer Health, Inc. All rights reserved. FAU - Madi, Rashad AU - Madi R AUID- ORCID: 0000-0002-7498-3244 AD - Departments of Radiology and Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. FAU - Khan, Sarem AU - Khan S AD - Division of Endocrinology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and. FAU - Rajapakse, Chamith S AU - Rajapakse CS AD - Departments of Radiology and Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. FAU - Khan, Amna N AU - Khan AN AD - Division of Endocrinology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and. FAU - Temme, Kate AU - Temme K AD - Department of Physical Medicine and Rehabilitation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. LA - eng PT - Journal Article DEP - 20241015 PL - United States TA - Clin J Sport Med JT - Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine JID - 9103300 SB - IM MH - Humans MH - *Bone Density MH - Retrospective Studies MH - Adult MH - *Running/injuries MH - *Cancellous Bone/diagnostic imaging MH - Male MH - *Fractures, Stress/diagnostic imaging MH - Female MH - Young Adult MH - Absorptiometry, Photon MH - Risk Assessment MH - Adolescent COIS- The authors report no conflicts of interest. EDAT- 2024/12/27 18:21 MHDA- 2025/02/28 18:22 CRDT- 2024/12/27 16:54 PHST- 2024/01/01 00:00 [received] PHST- 2024/09/04 00:00 [accepted] PHST- 2025/02/28 18:22 [medline] PHST- 2024/12/27 18:21 [pubmed] PHST- 2024/12/27 16:54 [entrez] AID - 00042752-202503000-00005 [pii] AID - 10.1097/JSM.0000000000001279 [doi] PST - ppublish SO - Clin J Sport Med. 2025 Mar 1;35(2):127-131. doi: 10.1097/JSM.0000000000001279. Epub 2024 Oct 15. PMID- 39728265 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250104 IS - 2411-5142 (Electronic) IS - 2411-5142 (Linking) VI - 9 IP - 4 DP - 2024 Dec 20 TI - Design of a Freely Accessible Web Application (Instrument for the Measurement of Balance in Primary Education, IMEP) for the Assessment of Static and Dynamic Balance in Children Aged 6-9 Years Based on Force Platforms. LID - 10.3390/jfmk9040281 [doi] LID - 281 AB - Background: The proper development of balance is essential in the acquisition of a correct physical condition, as well as in the evolutionary follow-up at early ages, and its periodic evaluation is very relevant in the educational environment. Objectives: The objective of this research was to design an accessible web application for static and dynamic balance assessment, based on a force platform and motion analysis software. Methods: The Single leg balance test (SLB), Tandem balance test (TBT), and Y balance test (YBT) were performed on a sample of 75 children aged 6 to 9 years. Results: The results show that static balance is more complex at an older age, greater standing height, and with eyes closed (p < 0.001). Regarding the center of pressure (COP), its variability was greater in girls owing to a lower Total Force (TF) at the time of the test (p < 0.05). Parallel observation with the Kinovea software has made it possible to elaborate a scale from 1 to 10 points for integration into an open-access web application (IMEP) to assess static and dynamic balance. Conclusions: The creation of an ad hoc application for primary school teachers and students has been possible by using validated devices obtaining a rating scale, which facilitate the monitoring of students' functional evolution and offers the possibility of scheduling physical education sessions with a preventive approach as well as a focus on improving physical condition. FAU - Martin-Ruiz, Julio AU - Martin-Ruiz J AUID- ORCID: 0000-0001-5089-8427 AD - Department of Health and Functional Assessment, Catholic University of Valencia, 46900 Valencia, Spain. FAU - Tamarit-Grancha, Ignacio AU - Tamarit-Grancha I AUID- ORCID: 0000-0003-2661-2649 AD - Department of Physical Preparation and Conditioning, Catholic University of Valencia, 46900 Valencia, Spain. FAU - Cordente-Martinez, Carlos AU - Cordente-Martinez C AUID- ORCID: 0000-0002-9038-8357 AD - Department of Sports, Polytechnic University of Madrid, 28040 Madrid, Spain. FAU - Santamaria-Fernandez, Raul AU - Santamaria-Fernandez R AD - Faculty of Sciences of Physical Activity and Sports, Catholic University of Valencia, 46900 Valencia, Spain. FAU - Ros Ros, Concepcion AU - Ros Ros C AD - Department of Sports Management and Physical Activity, Catholic University of Valencia, 46900 Valencia, Spain. FAU - Ruiz-Sanchis, Laura AU - Ruiz-Sanchis L AUID- ORCID: 0000-0003-0565-3329 AD - Department of Sports Management and Physical Activity, Catholic University of Valencia, 46900 Valencia, Spain. LA - eng PT - Journal Article DEP - 20241220 PL - Switzerland TA - J Funct Morphol Kinesiol JT - Journal of functional morphology and kinesiology JID - 101712257 PMC - PMC11679669 OTO - NOTNLM OT - balance OT - educational application OT - motion analysis OT - physical activity OT - primary education COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2024/12/27 12:20 MHDA- 2024/12/27 12:21 PMCR- 2024/12/20 CRDT- 2024/12/27 09:24 PHST- 2024/12/05 00:00 [received] PHST- 2024/12/18 00:00 [revised] PHST- 2024/12/20 00:00 [accepted] PHST- 2024/12/27 12:21 [medline] PHST- 2024/12/27 12:20 [pubmed] PHST- 2024/12/27 09:24 [entrez] PHST- 2024/12/20 00:00 [pmc-release] AID - jfmk9040281 [pii] AID - jfmk-09-00281 [pii] AID - 10.3390/jfmk9040281 [doi] PST - epublish SO - J Funct Morphol Kinesiol. 2024 Dec 20;9(4):281. doi: 10.3390/jfmk9040281. PMID- 39726936 OWN - NLM STAT- MEDLINE DCOM- 20241227 LR - 20260609 IS - 1399-5448 (Electronic) IS - 1399-543X (Print) IS - 1399-543X (Linking) VI - 2024 DP - 2024 TI - The Reproducibility and Reliability of Insulin Sensitivity and Secretion Indices in Children and Adolescents. LID - 2136173 [pii] LID - 10.1155/2024/2136173 [doi] AB - CONTEXT: Insulin sensitivity and secretion indices can be useful tools in understanding insulin homeostasis in children at risk for diabetes. There have been few studies examining the reproducibility of these measures in pediatrics. OBJECTIVE: To determine whether fasting or oral glucose tolerance test (OGTT)-derived insulin measures would be more reproducible and whether there would be differences based on weight, sex, race, and pubertal status. DESIGN: Observational study. SETTING: Clinical research unit. PATIENTS OR OTHER PARTICIPANTS: Two hundred fifty-seven overweight/obese (BMI >/= 85th%, n = 186) and normal weight (BMI < 85th%, n = 71) children without diabetes between ages of 8 and 17 were included in the study. METHODS: OGTT tests performed in study participants at two separate visits within a 3-week period. We performed two formal oral glucose tolerance tests within a 3-week period. The reproducibility of fasting measures was compared with OGTT-derived measures by weight categories and compared by weight, sex, race, and pubertal status. Comparisons were made between the correlation coefficients of fasting vs. OGTT-derived measures and between normal weight vs. obese/overweight participants, male vs. female, White vs. Black, and pre- vs. post-midpubertal. Intraclass correlation coefficients were calculated for each comparison as well. RESULTS: For insulin sensitivity, the OGTT-derived measure was more reproducible than the fasting measures. There were no significant differences in reproducibility in the overweight/obese population compared to the normal weight population nor by sex, race, or pubertal status. CONCLUSIONS: Nonfasting insulin sensitivity measures are more reproducible than fasting insulin sensitivity measures, regardless of weight category. Insulin secretion measures have poor reproducibility overall. Weight status, sex, race, and midpubertal stage do not impact the reproducibility of insulin sensitivity and secretion measures. FAU - Hani, Nellie Said AU - Hani NS AUID- ORCID: 0000-0002-7347-8211 AD - Department of Pediatrics, Division of Pediatric Endocrinology, University of Michigan, Ann Arbor, USA. FAU - Vajravelu, Mary Ellen AU - Vajravelu ME AUID- ORCID: 0000-0002-5839-7923 AD - Division of Pediatric Endocrinology, Diabetes and Metabolism, UPMC-Children's Hospital of Pittsburgh, Pittsburgh, USA. FAU - Meijer, Jennifer L AU - Meijer JL AUID- ORCID: 0000-0003-3100-1770 AD - Geisel School of Medicine, Department of Pediatrics, Dartmouth College, Hanover, USA. FAU - McCaffery, Harlan AU - McCaffery H AD - Susan B. Meister Child Health Evaluation and Research Center, Division of Pediatric Endocrinology, University of Michigan, Ann Arbor, USA. FAU - Sturza, Julie AU - Sturza J AD - Susan B. Meister Child Health Evaluation and Research Center, Division of Pediatric Endocrinology, University of Michigan, Ann Arbor, USA. FAU - Dhadphale, Emily AU - Dhadphale E AD - Susan B. Meister Child Health Evaluation and Research Center, Division of Pediatric Endocrinology, University of Michigan, Ann Arbor, USA. FAU - Lee, Joyce M AU - Lee JM AUID- ORCID: 0000-0002-8147-5168 AD - Department of Pediatrics, Division of Pediatric Endocrinology, University of Michigan, Ann Arbor, USA. LA - eng GR - UL1 TR000433/TR/NCATS NIH HHS/United States GR - T32 DK071212/DK/NIDDK NIH HHS/United States GR - P30 DK092926/DK/NIDDK NIH HHS/United States GR - P30 DK089503/DK/NIDDK NIH HHS/United States GR - R01 HD074559/HD/NICHD NIH HHS/United States GR - UL1 TR002240/TR/NCATS NIH HHS/United States GR - P30 DK020572/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Observational Study PT - Research Support, N.I.H., Extramural DEP - 20240430 PL - China TA - Pediatr Diabetes JT - Pediatric diabetes JID - 100939345 RN - 0 (Insulin) SB - IM MH - Humans MH - Child MH - Male MH - Female MH - *Insulin Resistance/physiology MH - Adolescent MH - Reproducibility of Results MH - *Glucose Tolerance Test MH - *Insulin/blood/metabolism MH - Insulin Secretion/physiology MH - Fasting/physiology MH - Pediatric Obesity/metabolism MH - Overweight/metabolism PMC - PMC11671114 MID - NIHMS2021474 COIS- Conflicts of Interest Dr. Lee is on the Medical Advisory Board for GoodRx, serves as a consultant to Tandem Diabetes Care, and has participated on the Sanofi Digital Advisory Board. All other authors have nothing to disclose. EDAT- 2024/12/27 06:20 MHDA- 2024/12/27 06:21 PMCR- 2024/04/30 CRDT- 2024/12/27 04:02 PHST- 2024/12/27 06:21 [medline] PHST- 2024/12/27 06:20 [pubmed] PHST- 2024/12/27 04:02 [entrez] PHST- 2024/04/30 00:00 [pmc-release] AID - 2136173 [pii] AID - 10.1155/2024/2136173 [doi] PST - ppublish SO - Pediatr Diabetes. 2024;2024:2136173. doi: 10.1155/2024/2136173. Epub 2024 Apr 30. PMID- 39726355 OWN - NLM STAT- MEDLINE DCOM- 20250429 LR - 20260614 IS - 2165-6509 (Electronic) IS - 1092-8529 (Linking) VI - 29 IP - 6 DP - 2024 Dec TI - Exploring the relationship among hikikomori tendencies, autistic traits, computer game use and eating disorder symptoms. PG - 670-681 LID - 10.1017/S1092852924002335 [doi] AB - OBJECTIVE: The hikikomori phenomenon has recently gained growing global interest, and evidences of its association with other psychopathological dimensions are slowly but steadily emerging. We aimed to evaluate the presence and correlates of hikikomori tendencies in an Italian University population, focusing on its relationships with autism spectrum, pathological computer gaming, and eating disorders. In particular, to our knowledge, no study has yet systematically evaluated the latter association, using psychometric instruments tailored to assess eating disorder symptoms. METHODS: 2574 students were recruited via an online survey. All participants were assessed with the Hikikomori Questionnaire-25 (HQ-25), the Adult Autism Subthreshold Spectrum Questionnaire (AdAS Spectrum), the Eating Attitude test-26 (EAT-26), and the Assessment of Internet and Computer Game Addiction (AICA-S). RESULTS: The results outlined how hikikomori risk was significantly correlated to autistic dimensions, altered eating behaviors, and videogame addiction. The closest relationship was detected with the autism spectrum. Interestingly, pathological computer gaming, most autistic dimensions, and EAT-26 oral control emerged as significant predictors of a greater risk for hikikomori, while the proneness to inflexibility and adherence to routine emerged as negative predictors. CONCLUSIONS: Our findings support the association among hikikomori, autism spectrum, pathological computer game use, and eating disorder symptoms. FAU - Carpita, Barbara AU - Carpita B AUID- ORCID: 0000-0002-2806-6736 AD - Department of Clinical and Experimental Medicine, University of Pisa, 56126Pisa, Italy. FAU - Nardi, Benedetta AU - Nardi B AUID- ORCID: 0000-0001-5437-7178 AD - Department of Clinical and Experimental Medicine, University of Pisa, 56126Pisa, Italy. FAU - Giovannoni, Federico AU - Giovannoni F AD - Department of Clinical and Experimental Medicine, University of Pisa, 56126Pisa, Italy. FAU - Parri, Francesca AU - Parri F AD - Department of Clinical and Experimental Medicine, University of Pisa, 56126Pisa, Italy. FAU - Cerofolini, Gianluca AU - Cerofolini G AD - Department of Clinical and Experimental Medicine, University of Pisa, 56126Pisa, Italy. FAU - Bonelli, Chiara AU - Bonelli C AD - Department of Clinical and Experimental Medicine, University of Pisa, 56126Pisa, Italy. FAU - Amatori, Giulia AU - Amatori G AUID- ORCID: 0000-0002-2818-4134 AD - Department of Clinical and Experimental Medicine, University of Pisa, 56126Pisa, Italy. FAU - Massimetti, Gabriele AU - Massimetti G AD - Department of Clinical and Experimental Medicine, University of Pisa, 56126Pisa, Italy. FAU - Cremone, Ivan Mirko AU - Cremone IM AD - Department of Clinical and Experimental Medicine, University of Pisa, 56126Pisa, Italy. FAU - Pini, Stefano AU - Pini S AD - Department of Clinical and Experimental Medicine, University of Pisa, 56126Pisa, Italy. FAU - Pellecchia, Enza AU - Pellecchia E AD - Department of Law, University of Pisa, 56126Pisa, Italy. FAU - Dell'Osso, Liliana AU - Dell'Osso L AD - Department of Clinical and Experimental Medicine, University of Pisa, 56126Pisa, Italy. LA - eng PT - Journal Article DEP - 20241227 PL - United States TA - CNS Spectr JT - CNS spectrums JID - 9702877 SB - IM MH - Humans MH - Male MH - Female MH - *Feeding and Eating Disorders/psychology/epidemiology MH - *Video Games/psychology MH - Young Adult MH - Adult MH - *Internet Addiction Disorder/psychology/epidemiology MH - Surveys and Questionnaires MH - Adolescent MH - *Behavior, Addictive/psychology MH - *Autism Spectrum Disorder/psychology MH - Italy/epidemiology OTO - NOTNLM OT - Hikikomori OT - autism spectrum disorder OT - autistic traits OT - feeding and eating disorders OT - video game addiction EDAT- 2024/12/27 06:19 MHDA- 2025/02/19 12:24 CRDT- 2024/12/27 03:13 PHST- 2025/02/19 12:24 [medline] PHST- 2024/12/27 06:19 [pubmed] PHST- 2024/12/27 03:13 [entrez] AID - S1092852924002335 [pii] AID - 10.1017/S1092852924002335 [doi] PST - ppublish SO - CNS Spectr. 2024 Dec;29(6):670-681. doi: 10.1017/S1092852924002335. Epub 2024 Dec 27. PMID- 39725794 OWN - NLM STAT- MEDLINE DCOM- 20241226 LR - 20261010 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 184 IP - 1 DP - 2024 Dec 26 TI - Comparison of different eGFR formulas to measured glomerular filtration rate using iohexol in children and adolescents with mild chronic kidney disease. PG - 107 LID - 10.1007/s00431-024-05937-1 [doi] AB - Estimated glomerular filtration rate (eGFR) based on different formulas is commonly used as a bedside tool to assess kidney function in children and young adults. The purpose of this study was to perform a measurement of glomerular filtration rate (mGFR) in children with chronic kidney disease (CKD) with a standard 5-point protocol using iohexol clearance and compare it to a simplified protocol for mGFR determination and to some of the most commonly used eGFR formulas. A 5-point standard protocol using iohexol clearance was used for determination of mGFR in 50 children with mild stages of CKD. The result was compared to 2- and 3-point sampling protocol as well as with some standard children eGFR formulas. We calculated the prediction performance for eGFR formulas to distinguish CKD1 and CKD 2 stages, formulas' accuracy, and cutoff values. Data were prospectively collected. All eGFR formulas exhibited a statistically significant positive correlation with mGFR. The best correlation was found with CKID2012 eGFR formula and with cystatin C-based eGFR formulas. The correlation between standard and simplified protocols for mGFR determination was also strong, while creatinine clearance did not prove to be a reliable method for estimating GFR. The error distribution with simplified protocols was not dispersed. The prediction value was strong for CKID2012 and bedside Schwartz formula. Conclusion: Fewer sampling points can be safely used for measuring GFR in children. eGFR formulas that are not based solely on creatinine should be considered more often in GFR estimation. What is Known? * Iohexol clearance is an established method of measuring GFR in children and adolescents using different protocols. * Estimating GFR in children and adolescents is troublesome and is done using different formulas with anthropometric and biochemical markers in children and adolescents. What is New? * Iohexol measurement with two or three blood withdrawals can reliably distinguish between CKD1 and CKD2 patients. * eGFR formulas have moderate reliability to predict distinguish between CKD1 and CKD2 patients, of which CKID2012 and bedside Schwartz formula were the most accurate in our study. CI - (c) 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Golob Jancic, Sonja AU - Golob Jancic S AD - Department of Paediatrics, University Medical Centre Maribor, Ljubljanska Ulica 5, 2000, Maribor, Slovenia. sonja.golobjancic@ukc-mb.si. FAU - Klavz, Janez AU - Klavz J AD - Department of Laboratory Diagnostics, University Medical Centre Maribor, Ljubljanska Ulica 5, 2000, Maribor, Slovenia. FAU - Filipic, Martina AU - Filipic M AD - Department of Paediatrics, University Medical Centre Maribor, Ljubljanska Ulica 5, 2000, Maribor, Slovenia. FAU - Mocnik, Mirjam AU - Mocnik M AD - Department of Paediatrics, University Medical Centre Maribor, Ljubljanska Ulica 5, 2000, Maribor, Slovenia. FAU - Marcun Varda, Natasa AU - Marcun Varda N AD - Department of Paediatrics, University Medical Centre Maribor, Ljubljanska Ulica 5, 2000, Maribor, Slovenia. LA - eng PT - Comparative Study PT - Journal Article DEP - 20241226 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 4419T9MX03 (Iohexol) RN - 0 (Contrast Media) RN - AYI8EX34EU (Creatinine) RN - 0 (Cystatin C) SB - IM MH - Humans MH - *Glomerular Filtration Rate MH - *Iohexol/pharmacokinetics MH - Child MH - Adolescent MH - *Renal Insufficiency, Chronic/physiopathology/blood/diagnosis MH - Female MH - Male MH - Prospective Studies MH - Contrast Media MH - Child, Preschool MH - Creatinine/blood MH - Cystatin C/blood OTO - NOTNLM OT - Child OT - Chronic kidney disease OT - Estimated glomerular filtration rate OT - Iohexol clearance measurement COIS- Declarations. Ethical approval: Parents, legal guardians, or adult participants received written information about the research protocol and provided informed consent by signing a declaration to participate. The study followed the principles outlined in the Declaration of Helsinki and obtained approval from both the Medical Ethics Commission of the University Clinical Centre Maribor (UKC-MB-KME-15/21) and the Medical Ethics Commission of the Republic of Slovenia (0120-347/2021/3). Competing interests: The authors declare no competing interests. EDAT- 2024/12/27 00:20 MHDA- 2024/12/27 00:21 CRDT- 2024/12/26 23:17 PHST- 2024/07/04 00:00 [received] PHST- 2024/12/15 00:00 [accepted] PHST- 2024/11/29 00:00 [revised] PHST- 2024/12/27 00:21 [medline] PHST- 2024/12/27 00:20 [pubmed] PHST- 2024/12/26 23:17 [entrez] AID - 10.1007/s00431-024-05937-1 [pii] AID - 10.1007/s00431-024-05937-1 [doi] PST - epublish SO - Eur J Pediatr. 2024 Dec 26;184(1):107. doi: 10.1007/s00431-024-05937-1. PMID- 39725063 OWN - NLM STAT- MEDLINE DCOM- 20250125 LR - 20260530 IS - 1095-8304 (Electronic) IS - 0195-6663 (Print) IS - 0195-6663 (Linking) VI - 206 DP - 2025 Feb 1 TI - Development and validation of a brief form of the Anticipated Effects of Food Scale. PG - 107843 LID - S0195-6663(24)00647-0 [pii] LID - 10.1016/j.appet.2024.107843 [doi] AB - Identifying malleable influences on eating behaviours will advance our ability to improve physical and mental health. Food-related emotional expectancies are the anticipated positive and negative emotions from eating different foods and are theorised to affect eating behaviour, and to be amenable to change. The Anticipated Effects of Food Scale (AEFS) assesses food-related emotional expectancies using 62 one-word items; however, a shorter questionnaire would be useful in large and clinical studies. In the present study, we developed a brief version of the AEFS, named the AEFS-Brief (AEFS-B), using a data-driven approach. We identified candidate items from all-subset correlations with the AEFS and item-level correlations with eating behaviours in two community samples (n = 247, n = 718), and we assessed internal consistency and validity of the AEFS-B. We further assessed internal consistency and validity in two independent samples (n = 200, n = 108) that completed a 'bogus' taste test or 24-h dietary recalls. Results indicated that the AEFS-B with 28 one-word items had good internal consistency and convergent validity with the AEFS. Analysis with AEFS-B scores reproduced associations of AEFS scores with intake of added sugars, symptoms of food addiction, eating to cope motives, and ad libitum food intake. We also demonstrated novel associations of AEFS and AEFS-B scores with emotional eating and diet quality. The AEFS-B appears to be a reliable and valid brief measure of food-related emotional expectancies that can be used in cohort and population studies, ecological momentary assessments, and for clinical populations in which participant burden is high. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Cummings, Jenna R AU - Cummings JR AD - Department of Psychology, Institute of Population Health, University of Liverpool, Liverpool, UK. Electronic address: jenna.cummings@liverpool.ac.uk. FAU - Treharne, Natasha AU - Treharne N AD - Department of Psychology, Institute of Population Health, University of Liverpool, Liverpool, UK. FAU - Vainik, Uku AU - Vainik U AD - Institute of Psychology, University of Tartu, Tartu, Estonia; Institute of Genomics, University of Tartu, Tartu, Estonia; Montreal Neurological Institute, McGill University, Montreal, Canada. FAU - Mason, Ashley E AU - Mason AE AD - Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA. FAU - Nansel, Tonja R AU - Nansel TR AD - Social and Behavioral Sciences Branch, Division of Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA. FAU - Lipsky, Leah M AU - Lipsky LM AD - Social and Behavioral Sciences Branch, Division of Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA. FAU - Gearhardt, Ashley N AU - Gearhardt AN AD - Department of Psychology, University of Michigan, Ann Arbor, Ann Arbor, MI, USA. LA - eng GR - HHSN275201300012C/HD/NICHD NIH HHS/United States GR - HHSN275201300026I/HD/NICHD NIH HHS/United States GR - T32 HD079350/HD/NICHD NIH HHS/United States GR - ZIA HD008983/ImNIH/Intramural NIH HHS/United States PT - Journal Article PT - Validation Study DEP - 20241224 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - *Feeding Behavior/psychology MH - Surveys and Questionnaires MH - Middle Aged MH - Young Adult MH - Reproducibility of Results MH - *Emotions MH - *Eating/psychology MH - Adolescent MH - *Diet/psychology MH - Aged PMC - PMC12314748 MID - NIHMS2098013 OTO - NOTNLM OT - Assessment OT - Brief OT - Eating behaviour OT - Emotions OT - Food-related emotional expectancies OT - Measurement COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/12/27 00:20 MHDA- 2025/01/26 02:11 PMCR- 2026/02/01 CRDT- 2024/12/26 19:16 PHST- 2024/09/30 00:00 [received] PHST- 2024/12/06 00:00 [revised] PHST- 2024/12/23 00:00 [accepted] PHST- 2025/01/26 02:11 [medline] PHST- 2024/12/27 00:20 [pubmed] PHST- 2024/12/26 19:16 [entrez] PHST- 2026/02/01 00:00 [pmc-release] AID - S0195-6663(24)00647-0 [pii] AID - 10.1016/j.appet.2024.107843 [doi] PST - ppublish SO - Appetite. 2025 Feb 1;206:107843. doi: 10.1016/j.appet.2024.107843. Epub 2024 Dec 24. PMID- 39724222 OWN - NLM STAT- MEDLINE DCOM- 20241226 LR - 20260611 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 12 DP - 2024 TI - Global screening of health behaviors: Introducing Lev-screening (Lev-s)-development and psychometric evaluation. PG - e0315565 LID - 10.1371/journal.pone.0315565 [doi] LID - e0315565 AB - Poor health behaviors have been identified as a critical factor for the burden on healthcare systems and individual suffering. However, comprehensive assessment of health behaviors is time-consuming and often neglected. To address this, we introduce the Lev-screening (Lev-s), a new, brief tool that covers multiple health behaviors. The Lev-s assesses ten health behaviors-physical activity, diet, alcohol use, tobacco use, illegal drug use, sleep, social relations, meaningful activities, sexual health, and screen health-using 33 items. This article details the development and psychometric evaluation of Lev-s with a sample of 2,279 participants aged 18-87. Test-retest reliability estimated as intra-class correlation coefficients for the different health behaviors ranged from .71 to .98 (n = 157), indicating moderate to excellent reliability. Lev-s showed associations with quality of life, demonstrated inter-correlations among included health behaviors, and detected group differences between individuals with and without neurodevelopmental conditions. The Lev-s exhibits satisfactory psychometric properties and holds promise as an efficient tool for screening of health behaviors. CI - Copyright: (c) 2024 Sjowall et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Sjowall, Douglas AU - Sjowall D AUID- ORCID: 0000-0002-8320-3609 AD - Department of Women's and Children's Health, Pediatric Neuropsychiatry Unit, Center for Neurodevelopmental Disorders at Karolinska Institutet (KIND), Center for Psychiatry Research Karolinska Institutet, Stockholm, Sweden. AD - Habilitation and Health, Stockholm Health Care Services, Region Stockholm, Sweden. AD - Center for Neurodevelopmental Disorders at Karolinska Institutet (KIND), CAP Research Center, Region Stockholm, Sweden. AD - Division of Psychology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. FAU - Stalhand, Felicia AU - Stalhand F AD - Independent Researcher. FAU - Schettini, Greta AU - Schettini G AD - Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Sweden. AD - Centre for Dependency Disorders, Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden. FAU - Gustavsson, Petter AU - Gustavsson P AD - Division of Psychology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. FAU - Hirvikoski, Tatja AU - Hirvikoski T AD - Department of Women's and Children's Health, Pediatric Neuropsychiatry Unit, Center for Neurodevelopmental Disorders at Karolinska Institutet (KIND), Center for Psychiatry Research Karolinska Institutet, Stockholm, Sweden. AD - Habilitation and Health, Stockholm Health Care Services, Region Stockholm, Sweden. AD - Center for Neurodevelopmental Disorders at Karolinska Institutet (KIND), CAP Research Center, Region Stockholm, Sweden. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241226 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Psychometrics/methods MH - Adult MH - Male MH - Adolescent MH - *Health Behavior MH - Female MH - Middle Aged MH - Aged MH - Young Adult MH - Aged, 80 and over MH - Reproducibility of Results MH - Surveys and Questionnaires MH - Mass Screening/methods MH - Quality of Life PMC - PMC11670939 COIS- The authors have declared that no competing interests exist EDAT- 2024/12/26 18:15 MHDA- 2024/12/26 18:16 PMCR- 2024/12/26 CRDT- 2024/12/26 15:55 PHST- 2024/08/30 00:00 [received] PHST- 2024/11/27 00:00 [accepted] PHST- 2024/12/26 18:16 [medline] PHST- 2024/12/26 18:15 [pubmed] PHST- 2024/12/26 15:55 [entrez] PHST- 2024/12/26 00:00 [pmc-release] AID - PONE-D-24-37493 [pii] AID - 10.1371/journal.pone.0315565 [doi] PST - epublish SO - PLoS One. 2024 Dec 26;19(12):e0315565. doi: 10.1371/journal.pone.0315565. eCollection 2024. PMID- 39722399 OWN - NLM STAT- MEDLINE DCOM- 20250429 LR - 20250806 IS - 1532-0480 (Electronic) IS - 1532-0464 (Linking) VI - 161 DP - 2025 Jan TI - Modeling repeated measurements data using the multilevel Bayesian network: A case of child morbidity. PG - 104760 LID - S1532-0464(24)00178-3 [pii] LID - 10.1016/j.jbi.2024.104760 [doi] AB - BACKGROUND AND OBJECTIVE: In epidemiological research, studying the long-term dependencies between multiple diseases is important. This study extends the multilevel Bayesian network (MBN) for repeated measures data that can estimate the rate of change in outcomes over time while quantifying the variabilities of these rates across higher-level units through various variance-covariance structures. METHOD: The performance and reliability of a model are examined through a simulation study, and its practical application is demonstrated using child morbidity data. This data has a hierarchical structure in which children were randomly selected from clusters (villages) and their conditions were assessed quarterly from March 2015 to May 2016. MBN was used to explore the relationship between outcomes weight-for-age (WAZ), height-for-age (HAZ), the number of days a child suffers from diarrhea (NOD), and flu (NOF), and estimate the rate of change of these outcomes over time. Since the outcomes considered were hybrid in nature, the connected three-parent set block Gibbs sampler with a multilevel generalized Poisson regression, multilevel zero inflated Poisson regression, and linear mixed-effects models were considered during the structure and parametric learning of the MBN. RESULT: The simulation study confirmed that a MBN using the time metric t as a node performed well for repeated measures data. The result from the structure learning of MBN shows a causal relationship between WAZ, HAZ, NOD and NOF. Furthermore, exclusive breastfeeding months and usage of micronutrient powder appeared as a strong predictor for all outcomes considered in this study. CONCLUSION: This study reveals that MBN is suitable in modeling repeated measures data to study the relationship between outcomes and estimate rate of change of an outcome over time while quantifying the variability due to higher-level clustering variables. Furthermore, the study highlights the importance of focusing on monitoring children with low WAZ and HAZ scores together with good feeding practices against the frequency of getting flu and diarrhea. CI - Copyright (c) 2024 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Yirdaw, Bezalem Eshetu AU - Yirdaw BE AD - Department of statistics, University of South Africa, c/o Christiaan de Wet Road & Pioneer Avenue, Johannesburg, 1709, Gauteng, South Africa. Electronic address: 12962805@mylife.unisa.ac.za. FAU - Debusho, Legesse Kassa AU - Debusho LK AD - Department of statistics, University of South Africa, c/o Christiaan de Wet Road & Pioneer Avenue, Johannesburg, 1709, Gauteng, South Africa. Electronic address: debuslk@unisa.ac.za. LA - eng PT - Journal Article DEP - 20241224 PL - United States TA - J Biomed Inform JT - Journal of biomedical informatics JID - 100970413 SB - IM MH - Humans MH - Bayes Theorem MH - Child MH - Morbidity MH - Computer Simulation MH - Infant MH - Child, Preschool MH - Diarrhea/epidemiology MH - *Models, Statistical MH - Female MH - Male OTO - NOTNLM OT - Anthropometry measurements OT - Hybrid outcomes OT - Linear mixed effects models OT - Multilevel Bayesian network OT - Multilevel zero inflated Poisson regression OT - Rate of change OT - Variance-covariance structure COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/12/26 06:20 MHDA- 2025/01/16 00:20 CRDT- 2024/12/26 01:11 PHST- 2024/04/24 00:00 [received] PHST- 2024/11/12 00:00 [revised] PHST- 2024/12/06 00:00 [accepted] PHST- 2025/01/16 00:20 [medline] PHST- 2024/12/26 06:20 [pubmed] PHST- 2024/12/26 01:11 [entrez] AID - S1532-0464(24)00178-3 [pii] AID - 10.1016/j.jbi.2024.104760 [doi] PST - ppublish SO - J Biomed Inform. 2025 Jan;161:104760. doi: 10.1016/j.jbi.2024.104760. Epub 2024 Dec 24. PMID- 39720688 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250104 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 15 DP - 2024 TI - Factors influencing students' happiness, vitality, and self-esteem. PG - 1463459 LID - 10.3389/fpsyg.2024.1463459 [doi] LID - 1463459 AB - INTRODUCTION: The happiness and well-being of individuals are among the most important components of life. However, there remains a lack of evidence regarding the relationships between students' happiness, vigor, and self-esteem on the one hand and various complex factors on the other hand. METHODS: We conducted a cross-sectional study involving 397 students from various Lithuanian universities. We determined students' happiness, self-esteem, vigor, healthy lifestyles, perceived stress, personality traits, academic achievements and motivation by using validated scales. RESULTS AND DISCUSSION: The study indicates that while happiness and self-esteem are not linked to healthy lifestyles, vigor is positively associated with moderate-to-vigorous physical activity (MVPA) and healthy eating, and negatively with body mass index (BMI). Happiness and vigor inversely relate to stress, and happiness and self-esteem inversely relate to depression. Vigor is positively related to extraversion, and self-esteem to neuroticism. Happiness, vigor, and self-esteem are not linked to academic achievements, but happiness relates to non-utilitarian decisions, and self-esteem to emotional intelligence and non-utilitarian decisions. Happiness, vigor, self-esteem were not linked to intrinsic motivation to study, but self-esteem was inversely related to amotivation and childhood violence. This study fills the research gap and deepens the understanding of what determines students' happiness and vigor, and self-esteem. CI - Copyright (c) 2024 Majauskiene, Istomina, Valanciene, Dadeliene, Sidlauskiene, Aukstikalnis, Jamontaite, Strazdaite, Zilinskiene, Gintiliene, Sarkauskiene and Skurvydas. FAU - Majauskiene, Daiva AU - Majauskiene D AD - Department of Rehabilitation, Physical and Sports Medicine, Faculty of Medicine, Institute of Health Sciences, Vilnius University, Vilnius, Lithuania. FAU - Istomina, Natalja AU - Istomina N AD - Department of Nursing, Faculty of Medicine, Institute of Health Sciences, Vilnius University, Vilnius, Lithuania. FAU - Valanciene, Dovile AU - Valanciene D AD - Faculty of Law, Vilnius University, Vilnius, Lithuania. FAU - Dadeliene, Ruta AU - Dadeliene R AD - Department of Rehabilitation, Physical and Sports Medicine, Faculty of Medicine, Institute of Health Sciences, Vilnius University, Vilnius, Lithuania. FAU - Sidlauskiene, Aurelija AU - Sidlauskiene A AD - Department of Rehabilitation, Physical and Sports Medicine, Faculty of Medicine, Institute of Health Sciences, Vilnius University, Vilnius, Lithuania. FAU - Aukstikalnis, Tomas AU - Aukstikalnis T AD - Department of Rehabilitation, Physical and Sports Medicine, Faculty of Medicine, Institute of Health Sciences, Vilnius University, Vilnius, Lithuania. FAU - Jamontaite, Ieva Egle AU - Jamontaite IE AD - Department of Rehabilitation, Physical and Sports Medicine, Faculty of Medicine, Institute of Health Sciences, Vilnius University, Vilnius, Lithuania. FAU - Strazdaite, Emilija AU - Strazdaite E AD - Department of Rehabilitation, Physical and Sports Medicine, Faculty of Medicine, Institute of Health Sciences, Vilnius University, Vilnius, Lithuania. FAU - Zilinskiene, Ramune AU - Zilinskiene R AD - Department of Rehabilitation, Physical and Sports Medicine, Faculty of Medicine, Institute of Health Sciences, Vilnius University, Vilnius, Lithuania. FAU - Gintiliene, Milda AU - Gintiliene M AD - Department of Rehabilitation, Kauno Kolegija, Higher Education Institution, Kaunas, Lithuania. FAU - Sarkauskiene, Asta AU - Sarkauskiene A AD - Department of Sports, Recreation and Tourism, Klaipeda University, Klaipeda, Lithuania. FAU - Skurvydas, Albertas AU - Skurvydas A AD - Department of Rehabilitation, Physical and Sports Medicine, Faculty of Medicine, Institute of Health Sciences, Vilnius University, Vilnius, Lithuania. LA - eng PT - Journal Article DEP - 20241210 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC11668144 OTO - NOTNLM OT - childhood negative experience OT - emotional intelligence OT - happiness OT - health and healthy lifestyles OT - life vitality OT - logical thinking OT - moral decision OT - personality traits COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/12/25 06:19 MHDA- 2024/12/25 06:20 PMCR- 2024/12/10 CRDT- 2024/12/25 04:28 PHST- 2024/07/11 00:00 [received] PHST- 2024/10/18 00:00 [accepted] PHST- 2024/12/25 06:20 [medline] PHST- 2024/12/25 06:19 [pubmed] PHST- 2024/12/25 04:28 [entrez] PHST- 2024/12/10 00:00 [pmc-release] AID - 10.3389/fpsyg.2024.1463459 [doi] PST - epublish SO - Front Psychol. 2024 Dec 10;15:1463459. doi: 10.3389/fpsyg.2024.1463459. eCollection 2024. PMID- 39720680 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250104 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 15 DP - 2024 TI - Autonomy support, basic needs satisfaction, and involvement in physical education among Norwegian secondary school students. PG - 1505710 LID - 10.3389/fpsyg.2024.1505710 [doi] LID - 1505710 AB - PURPOSE: This study investigated the relationship between teacher autonomy support, students' basic psychological needs satisfaction, and involvement in physical education (PE) with gender specific analyses. Additionally, the study examined the validity of a Norwegian version of the Basic Psychological Needs in PE (BPN-PE) scale. METHOD: Survey data from the Norwegian 2017/2018 Health Behaviour in School-aged Children study. RESULTS: A structural equation model showed that perceived autonomy support from teacher predicted students' basic needs satisfaction of competence, autonomy and relatedness. Furthermore, satisfaction of competence predicted weekly PE participation and physical activity during PE among boys. The analyses revealed mean level differences with boys scoring higher than girls on all the investigated variables. The findings also supported the validity and reliability of the BPN-PE scale across genders. DISCUSSION/CONCLUSION: The study adds knowledge to the understanding of the relationship between autonomy support from teachers, students basic need satisfaction and students' involvement in PE. CI - Copyright (c) 2024 Langoy, Diseth, Wold and Haug. FAU - Langoy, Amund AU - Langoy A AD - Department of Teacher Education, NLA University College, Bergen, Norway. AD - Department of Health Promotion and Development, University of Bergen, Bergen, Norway. FAU - Diseth, Age AU - Diseth A AD - Department of Education, University of Bergen, Bergen, Norway. FAU - Wold, Bente AU - Wold B AD - Department of Health Promotion and Development, University of Bergen, Bergen, Norway. FAU - Haug, Ellen AU - Haug E AD - Department of Teacher Education, NLA University College, Bergen, Norway. AD - Department of Health Promotion and Development, University of Bergen, Bergen, Norway. LA - eng PT - Journal Article DEP - 20241210 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC11667893 OTO - NOTNLM OT - PE teacher OT - basic psychological needs in PE scale OT - gender differences OT - participation in physical education OT - physical activity COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/12/25 06:19 MHDA- 2024/12/25 06:20 PMCR- 2024/12/10 CRDT- 2024/12/25 04:28 PHST- 2024/10/03 00:00 [received] PHST- 2024/11/27 00:00 [accepted] PHST- 2024/12/25 06:20 [medline] PHST- 2024/12/25 06:19 [pubmed] PHST- 2024/12/25 04:28 [entrez] PHST- 2024/12/10 00:00 [pmc-release] AID - 10.3389/fpsyg.2024.1505710 [doi] PST - epublish SO - Front Psychol. 2024 Dec 10;15:1505710. doi: 10.3389/fpsyg.2024.1505710. eCollection 2024. PMID- 39719383 OWN - NLM STAT- MEDLINE DCOM- 20250429 LR - 20250519 IS - 1097-4598 (Electronic) IS - 0148-639X (Print) IS - 0148-639X (Linking) VI - 71 IP - 3 DP - 2025 Mar TI - Physical Activity Correlates With Skeletal Muscle MRI Findings in Individuals With Duchenne Muscular Dystrophy. PG - 353-359 LID - 10.1002/mus.28323 [doi] AB - INTRODUCTION/AIMS: Skeletal muscle magnetic resonance imaging (MRI) is a validated noninvasive tool to assess Duchenne muscular dystrophy (DMD) progression. There is interest in finding DMD biomarkers that decrease the burden of clinical trial participation, such as wearable devices. Our aim was to evaluate the relationship between activity, via accelerometry, and skeletal muscle MRI, particularly T(2) mapping. METHODS: DMD children and young adults completed skeletal muscle MRI and were asked to wear an accelerometer on the dominant wrist for 7 days. MRI data included fat-suppressed transverse relaxation time (T(2)) mapping of the calves and longitudinal relaxation time (T(1)) mapping. Activity was assessed as vector magnitudes (VMs) and fraction of time (FOT) in activity groups (sedentary 1 or 2, low 1 or 2, moderate-to-vigorous physical activity (MVPA)). RESULTS: Participants (n = 22; median age 11.4 years, 41% ambulatory) wore the accelerometer for a median of 7 days. Longer T(2) in multiple lower extremity muscles was negatively correlated with VMs per minute (tibialis posterior Spearman's rho = -0.68, p < 0.001), even when accounting for age, ambulatory status, or glucocorticoid use. Longer T(2) of the tibialis posterior was positively correlated with FOT in sedentary 1 (rho = 0.49, p = 0.02) and negatively correlated with FOT in higher activity levels (low 1 (rho = -0.58, p = 0.004), low 2 (rho = -0.67, p = 0.002), MVPA (rho = -0.7, p < 0.001)). DISCUSSION: In individuals with DMD, longer T(2) on skeletal muscle MRI of the calves moderately correlated with lower activity levels indicating the potential use of home accelerometry as a future clinical trial biomarker of skeletal muscle health and progression in DMD. CI - (c) 2024 The Author(s). Muscle & Nerve published by Wiley Periodicals LLC. FAU - Tamaroff, Jaclyn AU - Tamaroff J AUID- ORCID: 0000-0002-3630-9937 AD - Division of Pediatric Endocrinology and Diabetes, Vanderbilt University Medical Center, Nashville, Tennessee, US. FAU - Joy, Nicholas AU - Joy N AD - Division of Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, Tennessee, US. FAU - Damon, Bruce AU - Damon B AD - Vanderbilt University Institute of Imaging Science and the Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, US. AD - Departments of Biomedical Engineering and Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, US. AD - Carle Clinical Imaging Research Program, Stephens Family Clinical Research Institute, Carle Health, Urbana, Illinois, US. FAU - Markham, Larry W AU - Markham LW AD - Division of Pediatric Cardiology, Riley Hospital for Children and Indiana University School of Medicine, Indianapolis, Indiana, US. FAU - Donnelly, Thomas AU - Donnelly T AD - Division of Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, Tennessee, US. FAU - Su, Karry AU - Su K AD - Division of Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, Tennessee, US. FAU - Buchowski, Maciej S AU - Buchowski MS AD - Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, US. FAU - Crum, Kimberly AU - Crum K AD - Division of Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, Tennessee, US. FAU - Slaughter, James C AU - Slaughter JC AD - Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, US. FAU - Xu, Meng AU - Xu M AD - Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, US. FAU - Burnette, W Bryan AU - Burnette WB AUID- ORCID: 0000-0002-7637-5330 AD - Division of Pediatric Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, US. FAU - Soslow, Jonathan AU - Soslow J AD - Division of Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, Tennessee, US. LA - eng GR - American Heart Association/ GR - FightDMD/ GR - R01 FD006649/FD/FDA HHS/United States GR - R01 AR057091/AR/NIAMS NIH HHS/United States GR - R01 DK118407/DK/NIDDK NIH HHS/United States GR - R01 AR073831/AR/NIAMS NIH HHS/United States GR - UL1 TR002243/TR/NCATS NIH HHS/United States GR - R56 HL141248/HL/NHLBI NIH HHS/United States GR - K23 HL123938/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20241224 PL - United States TA - Muscle Nerve JT - Muscle & nerve JID - 7803146 SB - IM MH - Humans MH - *Muscular Dystrophy, Duchenne/diagnostic imaging/physiopathology MH - Child MH - *Muscle, Skeletal/diagnostic imaging/physiopathology MH - Male MH - *Magnetic Resonance Imaging MH - Adolescent MH - *Exercise/physiology MH - Accelerometry MH - Young Adult MH - Female MH - Adult PMC - PMC11799400 MID - NIHMS2041892 OTO - NOTNLM OT - Duchenne muscular dystrophy OT - accelerometry OT - outcome measure OT - pediatrics OT - skeletal muscle MRI COIS- The authors declare no conflicts of interest. EDAT- 2024/12/25 00:20 MHDA- 2025/02/06 06:20 PMCR- 2025/02/06 CRDT- 2024/12/24 22:32 PHST- 2024/12/04 00:00 [revised] PHST- 2024/04/10 00:00 [received] PHST- 2024/12/08 00:00 [accepted] PHST- 2025/02/06 06:20 [medline] PHST- 2024/12/25 00:20 [pubmed] PHST- 2024/12/24 22:32 [entrez] PHST- 2025/02/06 00:00 [pmc-release] AID - MUS28323 [pii] AID - 10.1002/mus.28323 [doi] PST - ppublish SO - Muscle Nerve. 2025 Mar;71(3):353-359. doi: 10.1002/mus.28323. Epub 2024 Dec 24. PMID- 39716631 OWN - NLM STAT- MEDLINE DCOM- 20250429 LR - 20260530 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 206 DP - 2025 Feb 1 TI - Development and cultural adaptation of text messages for promoting healthy eating among Amazonian schoolchildren. PG - 107833 LID - S0195-6663(24)00637-8 [pii] LID - 10.1016/j.appet.2024.107833 [doi] AB - OBJECTIVE: To develop text messages for a mHealth intervention promoting healthy eating among Amazonian schoolchildren. DESIGN: Two rounds of expert panel analysis and formative research interviews. SETTING: Western Brazilian Amazon, Cruzeiro do Sul, Acre, Brazil. PARTICIPANTS: Included 17 healthcare professionals and 40 caregivers of school-aged children enrolled in the Maternal and Child Health and Nutrition in Acre birth cohort study. MAIN OUTCOME MEASURES: Evaluation focused on messages' cultural appropriateness, comprehensibility, and relevance, along with caregivers' understanding and intention to adhere to the recommendations. ANALYSIS: Quantitative analysis employed the modified Cohen Kappa, the Scale-Content Validity Index Average (S-CVI-Ave), frequency calculations, and a ranking system. RESULTS: Fifty-five text messages were drafted. In the initial stage, eight messages did not achieve a sufficient score and were subsequently revised and reevaluated, ultimately gaining approval. The S-CVI-Ave for each domain was as follows: cultural appropriateness = 0.97, comprehensibility = 0.96, and relevance = 0.97. Formative research indicated a 92% understanding rate and a 70% intention rate to adhere to the proposed suggestions. CONCLUSIONS AND IMPLICATIONS: The final set of messages was successfully culturally adapted and will contribute to the translation and dissemination of Dietary Guidelines for Brazilian Population recommendations to Western Amazon families. CI - Copyright (c) 2024 Elsevier Ltd. All rights reserved. FAU - Hovadick, Ana Carolina de Andrade AU - Hovadick ACA AD - Graduate Program in Public Health Nutrition, School of Public Health, University of Sao Paulo, Brazil. FAU - Moreira, Steffany Martins AU - Moreira SM AD - Department of Nutrition, School of Public Health, University of Sao Paulo, Brazil. FAU - Rodrigues, Caroline Zani AU - Rodrigues CZ AD - Graduate Program in Public Health Nutrition, School of Public Health, University of Sao Paulo, Brazil. FAU - Clarisse de Oliveira, Valeria AU - Clarisse de Oliveira V AD - Graduate Program in Public Health, School of Public Health, University of Sao Paulo, Brazil. FAU - Cardoso, Marly Augusto AU - Cardoso MA AD - Department of Nutrition, School of Public Health, University of Sao Paulo, Brazil; Global Health and Tropical Medicine, GHTM, Associate Laboratory in Translation and Innovation Towards Global Health, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, UNL, Lisboa, Portugal. Electronic address: marlyac@usp.br. LA - eng PT - Journal Article DEP - 20241221 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - *Text Messaging MH - Brazil MH - *Diet, Healthy/ethnology MH - Female MH - Child MH - *Health Promotion/methods MH - Male MH - Adult MH - Caregivers OTO - NOTNLM OT - Child health OT - Cultural adaptation OT - Healthy nutrition OT - Western Amazon OT - mHealth COIS- Declaration of competing interest The authors declare that they have no conflicts of interest associated with this manuscript. EDAT- 2024/12/24 06:20 MHDA- 2025/01/26 02:10 CRDT- 2024/12/24 01:44 PHST- 2024/03/11 00:00 [received] PHST- 2024/11/13 00:00 [revised] PHST- 2024/11/14 00:00 [accepted] PHST- 2025/01/26 02:10 [medline] PHST- 2024/12/24 06:20 [pubmed] PHST- 2024/12/24 01:44 [entrez] AID - S0195-6663(24)00637-8 [pii] AID - 10.1016/j.appet.2024.107833 [doi] PST - ppublish SO - Appetite. 2025 Feb 1;206:107833. doi: 10.1016/j.appet.2024.107833. Epub 2024 Dec 21. PMID- 39716307 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250104 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 12 IP - 1 DP - 2024 Dec 23 TI - Determinants of binge eating and its impact on indicators of obesity among Finnish adolescents - a cohort study. PG - 210 LID - 10.1186/s40337-024-01181-y [doi] LID - 210 AB - BACKGROUND: Binge eating, a type of disordered eating, is relatively common among youth and predisposes them to many adverse health outcomes. Diverse psychological and social factors may be associated with binge eating. The aim of this study was to examine child and parental psychosocial determinants of binge eating and its impact on indicators of obesity. METHODS: The sample consisted of 10 679 Finnish adolescents who participated in the Fin-HIT cohort study. The participants were 9-12 years at baseline, and they were followed-up for 2.6 years on average. At baseline, children's anthropometry was measured, and they reported binge eating, disordered eating attitudes and behaviors, self-esteem, and body shape satisfaction with validated questionnaires. Parents reported their own weight satisfaction, dieting, and depressive symptoms at baseline. Adjusted logistic and linear regressions were used in the analyses. RESULTS: Self-esteem was associated with lower odds (OR 0.88, 95% CI 0.85-0.91), and overall disordered eating attitudes and behaviors were associated with higher odds (OR 1.08, 95% CI 1.06-1.10) of binge eating. Additionally, child and parent body dissatisfaction were associated with binge eating but not in the fully adjusted model where the child's BMI was additionally considered. None of the parental factors were associated with binge eating in the fully adjusted model. Binge eating was associated with higher BMI z-scores and waist circumferences both cross-sectionally and longitudinally. CONCLUSIONS: In support of previous findings, we found that low self-esteem, body dissatisfaction and other disordered eating attitudes and behaviors are associated with binge eating, but our results also highlight the impact of weight status as a potential moderator when the determinants of binge eating are examined. More studies on the role of parental factors in adolescent binge eating are needed. CI - (c) 2024. The Author(s). FAU - Lehto, Reetta AU - Lehto R AD - Folkhalsan Research Center, Helsinki, Finland. AD - Department of Food and Nutrition, University of Helsinki, Helsinki, Finland. FAU - Algars, Monica AU - Algars M AD - Department of Psychology, University of Helsinki, Helsinki, Finland. FAU - Lommi, Sohvi AU - Lommi S AD - Folkhalsan Research Center, Helsinki, Finland. AD - Faculty of Medicine, University of Helsinki, Helsinki, Finland. FAU - Leppanen, Marja H AU - Leppanen MH AD - Folkhalsan Research Center, Helsinki, Finland. AD - Faculty of Medicine, University of Helsinki, Helsinki, Finland. AD - Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland. FAU - Viljakainen, Heli AU - Viljakainen H AD - Folkhalsan Research Center, Helsinki, Finland. heli.viljakainen@helsinki.fi. AD - Faculty of Medicine, University of Helsinki, Helsinki, Finland. heli.viljakainen@helsinki.fi. LA - eng PT - Journal Article DEP - 20241223 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC11667981 OAB - Binge eating is a type of disordered eating characterized by uncontrollable eating episodes that often negatively affects mental and physical health. We investigated the individual- and parent-related factors linked to binge eating and whether binge eating is related to BMI and waist circumference among adolescents. We studied 10,696 Finnish adolescents who were 9-12 years old at the beginning of the study. The participants' weight, height and waist circumference were measured, and they and their parents completed a questionnaire. The participants were followed up for 2.6 years on average. We found that low self-esteem and general disordered eating attitudes and behaviors were linked to binge eating. Additionally, body dissatisfaction present in the child or the parent was associated with the child's binge eating, but this depended on the child's BMI. Binge eating was repeatedly associated with a higher BMI and waist circumference. OABL- eng OTO - NOTNLM OT - Binge eating OT - Children OT - Determinants OT - Disordered eating OT - Family OT - Risk factors OT - Weight OT - Youth COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Ethics Committee of the Hospital District of Helsinki and Uusimaa (decision number 169/13/03/00/10). Written informed consent was obtained from all the participating children and their guardians. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2024/12/24 06:20 MHDA- 2024/12/24 06:21 PMCR- 2024/12/23 CRDT- 2024/12/24 00:06 PHST- 2024/08/30 00:00 [received] PHST- 2024/12/12 00:00 [accepted] PHST- 2024/12/24 06:21 [medline] PHST- 2024/12/24 06:20 [pubmed] PHST- 2024/12/24 00:06 [entrez] PHST- 2024/12/23 00:00 [pmc-release] AID - 10.1186/s40337-024-01181-y [pii] AID - 1181 [pii] AID - 10.1186/s40337-024-01181-y [doi] PST - epublish SO - J Eat Disord. 2024 Dec 23;12(1):210. doi: 10.1186/s40337-024-01181-y. PMID- 39716222 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250104 IS - 1743-7075 (Print) IS - 1743-7075 (Electronic) IS - 1743-7075 (Linking) VI - 21 IP - 1 DP - 2024 Dec 23 TI - Ultra-processed food intake in relation to metabolic health status in Iranian adolescents with overweight and obesity. PG - 111 LID - 10.1186/s12986-024-00886-w [doi] LID - 111 AB - BACKGROUND: Many studies have explored the association between food intake and metabolic health. However, research on the association of consuming ultra-processed foods (UPFs) and metabolic health in children and adolescents remains unclear. The objective of our study was to investigate the relation between UPFs consumption and metabolic health status in Iranian adolescents with overweight/obesity. METHODS: For this cross-sectional study, we selected a sample of 203 adolescents (101 boys and 102 girls) with a mean age of 13.98 +/- 1.61 who were chosen using a multistage cluster random sampling method. We collected data on their dietary patterns using a validated 147-item semi-quantitative food frequency questionnaire. Additionally, we measured anthropometric indices, blood pressure, fasting glucose, insulin, and lipid profiles. Participants were categorized to either metabolically healthy or unhealthy overweight/obesity (MHO and MUO) based on the International Diabetes Federation (IDF) and IDF/ Homeostasis Model Assessment Insulin Resistance (HOMA-IR) criteria. RESULTS: Our findings revealed that every 10 g/d increase in UPFs consumption was related to an elevated odds of MUO as defined by the IDF (OR = 1.14; 95%CI: 1.08-1.19) and IDF/HOMA-IR (OR = 1.14; 95%CI; 1.08-1.19) criteria, after controlling all confounders. The severity of this association varied among girls and boys and also among those with overweight and obesity according to the applied definitions. Moreover, each 10 g/d increase in daily UPFs intake was associated with increased odds of metabolic factors including hyperglycemia, hypertriglyceridemia, hypo-HDL-cholesterolemia, hypertension, and high insulin resistance levels. CONCLUSION: These findings highlighted a direct association between higher UPFs consumption and MUO status among adolescents. CI - (c) 2024. The Author(s). FAU - Farzam, Sana AU - Farzam S AD - Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Poursalehi, Donya AU - Poursalehi D AD - Students' Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran. AD - Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Mirzaei, Saeideh AU - Mirzaei S AD - Department of Community Nutrition, School of Nutrition and Food Science, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Asadi, Ali AU - Asadi A AD - Department of Exercise Physiology, School of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran. FAU - Akhlaghi, Masoumeh AU - Akhlaghi M AD - Department of Community Nutrition, School of Nutrition and Food Science, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Saneei, Parvane AU - Saneei P AD - Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. saneeip@yahoo.com. AD - Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, PO Box 81745-151, Isfahan, Iran. saneeip@yahoo.com. LA - eng PT - Journal Article DEP - 20241223 PL - England TA - Nutr Metab (Lond) JT - Nutrition & metabolism JID - 101231644 PMC - PMC11667992 OTO - NOTNLM OT - Adolescents OT - Metabolic health status OT - Obesity OT - Overweight OT - Ultra-processed foods COIS- Declarations. Ethical approval and consent to participate: The study procedure was performed according to declaration of Helsinki and STROBE checklist. All participants provided informed written consent. The study protocol was approved by the local Ethics Committee of Isfahan University of Medical Sciences. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2024/12/24 06:20 MHDA- 2024/12/24 06:21 PMCR- 2024/12/23 CRDT- 2024/12/24 00:01 PHST- 2024/01/13 00:00 [received] PHST- 2024/12/11 00:00 [accepted] PHST- 2024/12/24 06:21 [medline] PHST- 2024/12/24 06:20 [pubmed] PHST- 2024/12/24 00:01 [entrez] PHST- 2024/12/23 00:00 [pmc-release] AID - 10.1186/s12986-024-00886-w [pii] AID - 886 [pii] AID - 10.1186/s12986-024-00886-w [doi] PST - epublish SO - Nutr Metab (Lond). 2024 Dec 23;21(1):111. doi: 10.1186/s12986-024-00886-w. PMID- 39716140 OWN - NLM STAT- MEDLINE DCOM- 20241224 LR - 20260309 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 Dec 23 TI - Food insecurity and lifestyle behaviours in university students amidst the COVID-19 pandemic: a comparative survey across three countries. PG - 3571 LID - 10.1186/s12889-024-21033-3 [doi] LID - 3571 AB - BACKGROUND: University students, often unemployed and reliant on low-nutrition foods, are susceptible to food insecurity (FI) with potential physical and mental health challenges. This study explores FI and its impact on lifestyle behaviours among university students. METHODS: A cross-sectional web-based study was performed by sending an online questionnaire to university students in Lebanon, Cyprus, and Germany during the COVID-19 pandemic. Using validated measures, i.e., the Household Food Insecurity Access Scale, International Physical Activity Questionnaire, Pittsburgh Sleep Quality Index, and Mediterranean Diet Adherence Screener, adjusted linear regression models were performed to assess the associations between country, FI and physical activity, sleep quality, and diet. RESULTS: In a convenience sample of 611 individuals (350 in Germany, 214 in Lebanon, and 47 in Cyprus) enrolled in the study, 547 provided complete response. 190 (34.7%) experienced FI, of whom 52 (9.5%) were severely food-insecure, with variation of FI prevalence between countries (18.9% in Germany, 14.9% in Cyprus, and 60.3% in Lebanon). Lifestyle behaviours also differed between participants from the three countries, with students in Germany exhibiting the highest physical activity level and the lowest adherence to the Mediterranean diet compared with Lebanon and Cyprus. On the other hand, participants from Lebanon and Cyprus had similar physical activity and diet behaviours. Concerning sleep, students in Cyprus showed the poorest quality. FI significantly correlated with reduced physical activity (beta - 0.171, 95% Confidence Interval (-0.313, -0.029)), but not with sleep or diet. The country of residence independently predicted lifestyle behaviours (p < 0.05). CONCLUSIONS: This study suggests that FI impacts university students in countries of varying income levels, and the country of residence independently influences lifestyle behaviours. Larger-size studies are essential to confirm these findings and further explore FI's impact on university students outside the context of the pandemic. CI - (c) 2024. The Author(s). FAU - Witkowiak, Maria M AU - Witkowiak MM AD - Department of Basic and Clinical Sciences, University of Nicosia Medical School, Nicosia, Cyprus. FAU - Idris, Adama Nana AU - Idris AN AD - Department of Basic and Clinical Sciences, University of Nicosia Medical School, Nicosia, Cyprus. FAU - Sato, Alma AU - Sato A AD - Department of Basic and Clinical Sciences, University of Nicosia Medical School, Nicosia, Cyprus. FAU - Sacre, Hala AU - Sacre H AD - INSPECT-LB (Institut National de Sante Publique, Epidemiologie Clinique et Toxicologie - Liban), Beirut, Lebanon. FAU - Haddad, Chadia AU - Haddad C AD - INSPECT-LB (Institut National de Sante Publique, Epidemiologie Clinique et Toxicologie - Liban), Beirut, Lebanon. AD - School of Medicine, Lebanese American University, Beirut, Lebanon. FAU - Rizk, Rana AU - Rizk R AD - INSPECT-LB (Institut National de Sante Publique, Epidemiologie Clinique et Toxicologie - Liban), Beirut, Lebanon. AD - School of Arts and Sciences, Lebanese American University, Byblos, Lebanon. FAU - Malaeb, Diana AU - Malaeb D AD - INSPECT-LB (Institut National de Sante Publique, Epidemiologie Clinique et Toxicologie - Liban), Beirut, Lebanon. AD - College of Pharmacy, Gulf Medical University, Ajman, United Arab Emirates. FAU - Strahler, Jana AU - Strahler J AD - Sport Psychology, Institute of Sport and Sport Science, Albert-Ludwigs-University Freiburg, Freiburg Im Breisgau, Germany. FAU - Salameh, Pascale AU - Salameh P AD - INSPECT-LB (Institut National de Sante Publique, Epidemiologie Clinique et Toxicologie - Liban), Beirut, Lebanon. AD - School of Medicine, Lebanese American University, Beirut, Lebanon. AD - Faculty of Pharmacy, Lebanese University, Hadath, Lebanon. AD - Department of Primary Care and Population Health, University of Nicosia Medical School, 21 Ilia Papakyriakou, 1st Floor, Block C, Engomi, Nicosia, Nicosia, 2414, Cyprus. FAU - Ierodiakonou, Despo AU - Ierodiakonou D AD - Department of Primary Care and Population Health, University of Nicosia Medical School, 21 Ilia Papakyriakou, 1st Floor, Block C, Engomi, Nicosia, Nicosia, 2414, Cyprus. ierodiakonou.d@unic.ac.cy. LA - eng PT - Comparative Study PT - Journal Article DEP - 20241223 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - *COVID-19/epidemiology/prevention & control MH - *Students/statistics & numerical data/psychology MH - Female MH - Male MH - Cross-Sectional Studies MH - Universities MH - Lebanon/epidemiology MH - Germany/epidemiology MH - *Life Style MH - Young Adult MH - Cyprus/epidemiology MH - Adult MH - *Food Insecurity MH - *Exercise MH - Surveys and Questionnaires MH - Pandemics MH - Adolescent PMC - PMC11665100 OTO - NOTNLM OT - Economy OT - Food insecurity OT - Healthy eating OT - Lifestyle OT - Mediterranean diet OT - Physical activity OT - Sleep OT - University students COIS- Declarations. Ethics approval and consent to participate: This study was conducted according to the guidelines laid down in the Declaration of Helsinki and all procedures involving research study participants were approved a priori by the INSPECT-LB Research Ethics Committee (2021REC-002-INSPECT-09-17). In every country, participation was entirely voluntary and confidential, and participants had the option to withdraw at any stage. Before completing the questionnaire, participants were briefed on the study objectives, and inclusion was contingent upon their consent, which was obtained on the initial page of the online survey. No form of compensation, whether financial or otherwise, was offered to participants for their involvement. The convenience sampling being observational with no traceability of patients offers a further guarantee of participants' information confidentiality. All study participants provided informed consent before data collection. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. EDAT- 2024/12/24 00:25 MHDA- 2024/12/24 06:20 PMCR- 2024/12/23 CRDT- 2024/12/23 23:57 PHST- 2024/06/08 00:00 [received] PHST- 2024/12/09 00:00 [accepted] PHST- 2024/12/24 06:20 [medline] PHST- 2024/12/24 00:25 [pubmed] PHST- 2024/12/23 23:57 [entrez] PHST- 2024/12/23 00:00 [pmc-release] AID - 10.1186/s12889-024-21033-3 [pii] AID - 21033 [pii] AID - 10.1186/s12889-024-21033-3 [doi] PST - epublish SO - BMC Public Health. 2024 Dec 23;24(1):3571. doi: 10.1186/s12889-024-21033-3. PMID- 39715056 OWN - NLM STAT- MEDLINE DCOM- 20241223 LR - 20241226 IS - 0035-7715 (Print) IS - 0035-7715 (Linking) VI - 75 IP - 3 DP - 2024 Dec 23 TI - Selected eating behaviors and the risk of orthorexia nervosa in a group of high school students. PG - 247-254 LID - 192744 [pii] LID - 10.32394/rpzh/192744 [doi] AB - BACKGROUND: Orthorexia nervosa (ON), or the obsessive desire to eat only healthy foods, is closely linked to eating behaviors. Among adolescents, the risk of developing ON and its consequences, including weight loss and malnutrition, can be particularly significant due to the crucial impact of eating behaviors on an individual's psychophysical development. OBJECTIVE: The aim of the study was to examine the relationship between the eating behaviors of high school students and the risk of ON. MATERIAL AND METHODS: Observational study was conducted using the PAPI method among 514 students aged 14-19, of which 59.3% (N=305) were female. The research tool was a proprietary, validated questionnaire that included the ORTO-15 test (cutoff score=35) and the BSQFVF. The questionnaire was used to assess the frequency of consumption of selected food products, the level of dietary fiber intake, the quantity and regularity of meals consumed, as well as other eating behaviors of the participants. The individual responses were then analyzed according to the risk of ON using correlation coefficients. RESULTS: The prevalence of ON risk was found to be 32.1% (N=165). The percentage of individuals at risk of ON was higher among vegetarians. The results regarding the frequency of consumption of animal protein sources, dietary fiber intake, the number of meals and their regularity were similar in both the group at risk of ON and the group not at risk. Over 80% of individuals who never consumed bars, gummies, and candies were at risk of developing ON. CONCLUSIONS: The risk of ON was higher among vegetarians. Individuals who excluded highly processed foods from their diet were more susceptible to developing ON. FAU - Kozik, Karolina AU - Kozik K AD - Scientific Circle at the Department of Human Nutrition, Faculty of Public Health in Bytom, Silesian Medical University in Katowice, Poland. FAU - Calyniuk, Beata AU - Calyniuk B AD - Department of Human Nutrition, Faculty of Public Health in Bytom, Silesian Medical University in Katowice, Poland. LA - eng PT - Journal Article PT - Observational Study DEP - 20240912 PL - Poland TA - Rocz Panstw Zakl Hig JT - Roczniki Panstwowego Zakladu Higieny JID - 0414756 SB - IM MH - Humans MH - Female MH - Adolescent MH - *Feeding Behavior/psychology MH - *Feeding and Eating Disorders/epidemiology/psychology MH - Male MH - *Students/statistics & numerical data/psychology MH - Young Adult MH - Poland/epidemiology MH - Adolescent Behavior/psychology MH - Health Behavior MH - Surveys and Questionnaires MH - Risk Factors OTO - NOTNLM OT - ORTO-15 OT - ORTO-35 OT - adolescents OT - eating behaviors OT - orthorexia nervosa EDAT- 2024/12/23 22:59 MHDA- 2024/12/23 23:00 CRDT- 2024/12/23 12:53 PHST- 2024/12/23 23:00 [medline] PHST- 2024/12/23 22:59 [pubmed] PHST- 2024/12/23 12:53 [entrez] AID - 192744 [pii] AID - 10.32394/rpzh/192744 [doi] PST - ppublish SO - Rocz Panstw Zakl Hig. 2024 Dec 23;75(3):247-254. doi: 10.32394/rpzh/192744. Epub 2024 Sep 12. PMID- 39713156 OWN - NLM STAT- MEDLINE DCOM- 20241223 LR - 20260607 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 12 DP - 2024 TI - Developing the developmental origins of health and disease (DOHaD) awareness scale to assess an education module for improving dietary behavior among college students. PG - e18669 LID - 10.7717/peerj.18669 [doi] LID - e18669 AB - OBJECTIVE: This study aimed to develop and validate the Developmental Origins of Health and Disease (DOHaD) awareness scale and examine whether having a DOHaD education module may affect dietary behavior in college students. BACKGROUND: Some studies conducted within the scope of the DOHaD hypothesis show associations between early-life environmental factors, especially maternal health and nutritional status, with the next generation's health and disease status. Despite the increase in elucidating of the underpinning mechanisms of early life determinants and chronic disease risk, there is limited knowledge on how public perceive and understand DOHaD concepts. METHODS: The study consisted of three phases: identification of DOHaD awareness scale components, development and validation, interrater reliability of the scale, and a confirmatory study. Two-hundred college students to confirm face validity of the scale, one-hundred for reproducibility and one-hundred for the confirmatory study. Confirmatory study included a pre-intervention period in which baseline parameters (such as anthropometric measurements, HEI-2015 (Healthy Eating Index-2015), physical activity levels, and DOHaD awareness scale scores) were measured at two different time points, and an educational module on DOHaD concepts was provided to the participants. The study was reported in accordance with the Guidelines for Reporting Reliability and Agreement Studies (GRRAS). RESULTS: Content validity ratio, exploratory factor analysis, and Cronbach's alpha values indicated that a reliable and valid instrument to assess the awareness of DOHaD concepts in college students was developed. Despite the lack of a control group, DOHaD concept education was associated with improved anthropometric measurements, healthier eating parameters, increased physical activity levels, and a better understanding of DOHaD concepts. CONCLUSIONS: Translating DOHaD concepts into healthier behaviors can support improvements in lifestyle, and the use of the DOHaD awareness scale may serve as a valuable tool to encourage healthy behaviors among college students. CI - (c) 2024 Imre and Akyol. FAU - Imre, Kadriye Elif AU - Imre KE AD - Department of Nutrition and Dietetics, Kastamonu University, Kastamonu, Turkey. FAU - Akyol, Asli AU - Akyol A AD - Departmant of Nutrition and Dietetics, Hacettepe University, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20241219 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - Female MH - Male MH - *Students/psychology MH - Reproducibility of Results MH - Young Adult MH - *Health Knowledge, Attitudes, Practice MH - Universities MH - Feeding Behavior/psychology MH - Surveys and Questionnaires MH - Adult MH - Awareness MH - Health Education/methods MH - Adolescent PMC - PMC11663402 OTO - NOTNLM OT - Developmental origins of health and disease OT - Diet quality OT - Knowledge transition OT - Nutrition OT - Pregnancy COIS- The authors declare that they have no competing interests. EDAT- 2024/12/23 17:24 MHDA- 2024/12/23 17:25 PMCR- 2024/12/19 CRDT- 2024/12/23 06:17 PHST- 2024/05/28 00:00 [received] PHST- 2024/11/19 00:00 [accepted] PHST- 2024/12/23 17:25 [medline] PHST- 2024/12/23 17:24 [pubmed] PHST- 2024/12/23 06:17 [entrez] PHST- 2024/12/19 00:00 [pmc-release] AID - 18669 [pii] AID - 10.7717/peerj.18669 [doi] PST - epublish SO - PeerJ. 2024 Dec 19;12:e18669. doi: 10.7717/peerj.18669. eCollection 2024. PMID- 39712343 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20251221 IS - 2251-6581 (Print) IS - 2251-6581 (Electronic) IS - 2251-6581 (Linking) VI - 24 IP - 1 DP - 2025 Jun TI - The association between dietary intake of branched-chain amino acids and the odds of nonalcoholic fatty liver disease among overweight and obese children and adolescents. PG - 19 LID - 10.1007/s40200-024-01516-1 [doi] LID - 19 AB - OBJECTIVES: Dietary supplementation with branched-chain amino acids (BCAAs), including leucine, isoleucine, and valine, has shown potential benefits for the metabolic profile. However, emerging population-based studies suggest that BCAAs may mediate pathways related to cardiometabolic risk factors, possibly due to their involvement in the dysregulation of insulin metabolic pathways. This study aimed to investigate the association between BCAAs intake and the odds of nonalcoholic fatty liver disease (NAFLD) in children and adolescents with overweight and obesity. METHODS: This cross-sectional study encompassed individuals aged 6 to 18 years with WHO body mass index (BMI)-for-age z-score >/= 1. NAFLD diagnosis was done using an ultrasonography scan of the liver and gastroenterologist confirmation. Dietary BCAAs intake was assessed using a validated 147-item food frequency questionnaire. Logistic regression models, adjusted for potential confounders, were used to estimate the odds ratios (OR) and 95% confidence interval (CI) of NAFLD across quartiles of BCAAs intake. RESULTS: A total of 505 (52.9% boys) with mean +/- SD age and BMI-for-age-Z-score of 10.0 +/- 2.3 and 2.70 +/- 1.01, respectively, were enrolled. After adjusting for potential confounders, participants in the highest quartile of total dietary BCAAs (OR: 1.87;95%CI:1.06-3.28) and leucine (OR: 1.84;95%CI:1.03-3.29) intake had greater odds of developing NAFLD compared with those in the lowest quartile. There was no significant association between dietary valine and isoleucine intake and the odds of NAFLD. CONCLUSIONS: The study findings suggest that increased dietary intake of BCAAs, particularly leucine, may have detrimental effects on the development of NAFLD. CI - (c) The Author(s), under exclusive licence to Tehran University of Medical Sciences 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. FAU - Nikparast, Ali AU - Nikparast A AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/034m2b326. GRID: grid.411600.2 AD - Pediatric Gastroenterology and Hepatology Research Center Pediatrics Centre of Excellence Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/01c4pz451. GRID: grid.411705.6. ISNI: 0000 0001 0166 0922 FAU - Razavi, Maryam AU - Razavi M AD - Growth and development research center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/01c4pz451. GRID: grid.411705.6. ISNI: 0000 0001 0166 0922 FAU - Sohouli, Mohammad Hassan AU - Sohouli MH AD - Pediatric Gastroenterology and Hepatology Research Center Pediatrics Centre of Excellence Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/01c4pz451. GRID: grid.411705.6. ISNI: 0000 0001 0166 0922 FAU - Hekmatdoost, Azita AU - Hekmatdoost A AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/034m2b326. GRID: grid.411600.2 FAU - Dehghan, Pooneh AU - Dehghan P AD - Department of Imaging, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/034m2b326. GRID: grid.411600.2 FAU - Tohidi, Maryam AU - Tohidi M AD - Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/034m2b326. GRID: grid.411600.2 FAU - Rouhani, Pejman AU - Rouhani P AD - Pediatric Gastroenterology and Hepatology Research Center Pediatrics Centre of Excellence Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/01c4pz451. GRID: grid.411705.6. ISNI: 0000 0001 0166 0922 FAU - Asghari, Golaleh AU - Asghari G AUID- ORCID: 0000-0002-7925-5158 AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/034m2b326. GRID: grid.411600.2 LA - eng PT - Journal Article DEP - 20241220 PL - Switzerland TA - J Diabetes Metab Disord JT - Journal of diabetes and metabolic disorders JID - 101590741 PMC - PMC11659539 OTO - NOTNLM OT - Branched-chain amino acid intake OT - Children OT - Insulin resistance OT - Nonalcoholic fatty liver disease OT - Overweight and obesity COIS- Competing interestsThe authors declare that they have no competing interests. EDAT- 2024/12/23 17:24 MHDA- 2024/12/23 17:25 PMCR- 2025/12/20 CRDT- 2024/12/23 06:05 PHST- 2024/10/18 00:00 [received] PHST- 2024/11/08 00:00 [accepted] PHST- 2024/12/23 17:25 [medline] PHST- 2024/12/23 17:24 [pubmed] PHST- 2024/12/23 06:05 [entrez] PHST- 2025/12/20 00:00 [pmc-release] AID - 1516 [pii] AID - 10.1007/s40200-024-01516-1 [doi] PST - epublish SO - J Diabetes Metab Disord. 2024 Dec 20;24(1):19. doi: 10.1007/s40200-024-01516-1. eCollection 2025 Jun. PMID- 39705123 OWN - NLM STAT- MEDLINE DCOM- 20250428 LR - 20250910 IS - 1533-4287 (Electronic) IS - 1064-8011 (Linking) VI - 39 IP - 4 DP - 2025 Apr 1 TI - Reliability and Sensitivity of Using Isometric Strength and Sprint Speed Measures in Adolescent Female Athletes. PG - 418-426 LID - 10.1519/JSC.0000000000005029 [doi] AB - Salter, J, Forsdyke, D, Dawson, Z, Rymer, J, Walsh, L, and Mundy, P. Reliability and sensitivity of using isometric strength and sprint speed measures in adolescent female athletes. J Strength Cond Res 39(4): 418-426, 2025-The aim of this study was to establish the reliability and sensitivity of isometric mid-thigh pull (IMTP) and sprint speed (5 m, 40 m, and maximal sprint speed) in adolescent women, before exploring the stability of this across maturation to provide maturity-specific benchmarks. A total of 147 female athletes (age: 13.8 +/- 2.8 years; stature: 157.1 +/- 13.1 cm; body mass: 51.2 +/- 15.3 kg; percentage of predicated adult height: 94.3 +/- 6.6) performed IMTP and sprint trials on 2 occasions, separated by 7 days. Within- and between-session reliability was determined using intraclass correlation coefficient (ICC), coefficient of variation, and Bland-Altman limits of agreement, with sensitivity detected by signal-to-noise ratios for small (SWC 0.2 ) and moderate (SWC 0.5 ) worthwhile change. A between-group analysis of variance and Cohen's d -effect sizes determined differences between biological maturity groups (pre-, mid-, and post-peak height velocity [PHV]). All isometric strength and sprint performance markers demonstrated either " moderate " or " acceptabl e" within-session reliability, except for time to peak force (PF) and 40 m sprint. Despite metrics all having " high " or above ICC (0.55-0.98), only PF offered a " good " sensitivity when using SWC 0.2 , with most offering better sensitivity with SWC 0.5 . Noise was higher between sessions, resulting in " poor " signal-noise ratios, likely associated with the bias favoring retest trials. Reliability and sensitivity findings were consistent across maturational stages, demonstrating either " moderate " or " acceptable " reliability. There were clear differences between maturity groups for all measures, particularly between mid-PHV and post-PHV. Practitioners can be assured that IMTP and sprint performance measures are reliable within this population but require thorough familiarization processes before confidence in interpreting meaningful changes. CI - Copyright (c) 2024 National Strength and Conditioning Association. FAU - Salter, Jamie AU - Salter J AD - InSPIRe Group, School of Science, Technology & Health, York St John University, York, United Kingdom; and. FAU - Forsdyke, Dale AU - Forsdyke D AD - InSPIRe Group, School of Science, Technology & Health, York St John University, York, United Kingdom; and. FAU - Dawson, Zoe AU - Dawson Z AD - InSPIRe Group, School of Science, Technology & Health, York St John University, York, United Kingdom; and. FAU - Rymer, Jacob AU - Rymer J AD - InSPIRe Group, School of Science, Technology & Health, York St John University, York, United Kingdom; and. FAU - Walsh, Luke AU - Walsh L AD - InSPIRe Group, School of Science, Technology & Health, York St John University, York, United Kingdom; and. FAU - Mundy, Peter AU - Mundy P AD - Hawkin Dynamics, Inc, Westbrook, Maine. LA - eng GR - TASS (Talented Athlete Scholarship Scheme)/ PT - Journal Article DEP - 20241219 PL - United States TA - J Strength Cond Res JT - Journal of strength and conditioning research JID - 9415084 SB - IM MH - Humans MH - Female MH - Adolescent MH - Reproducibility of Results MH - *Running/physiology MH - *Muscle Strength/physiology MH - *Athletic Performance/physiology MH - Athletes MH - *Isometric Contraction/physiology MH - Exercise Test/methods EDAT- 2024/12/20 18:20 MHDA- 2025/03/28 18:25 CRDT- 2024/12/20 12:32 PHST- 2025/03/28 18:25 [medline] PHST- 2024/12/20 18:20 [pubmed] PHST- 2024/12/20 12:32 [entrez] AID - 00124278-202504000-00004 [pii] AID - 10.1519/JSC.0000000000005029 [doi] PST - ppublish SO - J Strength Cond Res. 2025 Apr 1;39(4):418-426. doi: 10.1519/JSC.0000000000005029. Epub 2024 Dec 19. PMID- 39704447 OWN - NLM STAT- Publisher LR - 20241220 IS - 1475-2662 (Electronic) IS - 0007-1145 (Linking) DP - 2024 Dec 20 TI - Food insecurity and BMI are associated with depressive symptoms among adolescents in Yogyakarta province, Indonesia, during the COVID-19 pandemic: a 1-year longitudinal study. PG - 1-10 LID - 10.1017/S0007114524003027 [doi] AB - The COVID-19 pandemic has presented multifaceted challenges globally, impacting adolescent health. Among these, food security and nutrition are intertwined closely with mental health outcomes. In Indonesia, with its diverse socio-economic landscape, these interconnections may have been exacerbated by the pandemic. This study investigated the relationship between food security, nutrition and adolescent mental health in Indonesia during COVID-19. Longitudinal data were collected from 511 adolescent boys and girls in 2021-2022 in Gunungkidul district, Yogyakarta. Food security was measured using the Household Food Insecurity Access Scale (HFIAS), and the validated Kessler-10 Psychological Distress Scale (K10) was used to measure adolescent depression. Multivariate linear regression and linear mixed-effects regression were employed to explore associations between these variables, while adjusting for sex, age, pubertal status and household income. Overall, food insecurity score was positively associated with depressive symptoms (beta: 0.72, 95 % CI 0.52, 0.92), while BMI z-score was inversely associated (beta: -0.31, 95 % CI 0.68, -0.03). We found an increase in strength of association between food insecurity and depressive symptoms over time (moderately food-insecure: beta: 1.36 (95 % CI -0.10, 2.83) to 4.63 (95 % CI 2.17, 7.09); severely food-insecure: beta: 1.89 (95 % CI 0.36, 3.41) to 3.30 (95 % CI 1.50, 5.10). Enhancing food access, improving nutritional status and providing mental health support are crucial components of adolescent health. FAU - Asrullah, Muhammad AU - Asrullah M AUID- ORCID: 0000-0002-7847-3153 AD - Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, the Netherlands. AD - Centre for Health Policy and Management, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia. FAU - Maula, Ahmad Watsiq AU - Maula AW AD - Biostatistic, Epidemiology, and Population Health, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia. FAU - Dewi, Shita Listya AU - Dewi SL AD - Centre for Health Policy and Management, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia. FAU - Helmyati, Siti AU - Helmyati S AD - Department of Nutrition and Health, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia. FAU - Melse-Boonstra, Alida AU - Melse-Boonstra A AUID- ORCID: 0000-0001-8406-7592 AD - Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, the Netherlands. LA - eng PT - Journal Article DEP - 20241220 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM OTO - NOTNLM OT - Adolescents OT - Anaemia OT - BMI OT - COVID-19 pandemic OT - Depression OT - Food insecurity OT - Indonesia OT - Nutrition EDAT- 2024/12/20 12:21 MHDA- 2024/12/20 12:21 CRDT- 2024/12/20 08:13 PHST- 2024/12/20 12:21 [medline] PHST- 2024/12/20 12:21 [pubmed] PHST- 2024/12/20 08:13 [entrez] AID - S0007114524003027 [pii] AID - 10.1017/S0007114524003027 [doi] PST - aheadofprint SO - Br J Nutr. 2024 Dec 20:1-10. doi: 10.1017/S0007114524003027. PMID- 39704056 OWN - NLM STAT- MEDLINE DCOM- 20241220 LR - 20260323 IS - 1365-2753 (Electronic) IS - 1356-1294 (Linking) VI - 31 IP - 1 DP - 2025 Feb TI - Translation, Cross-Cultural Adaptation and Validation of the Karaduman Chewing Performance Scale for the Italian Paediatric Population. PG - e14283 LID - 10.1111/jep.14283 [doi] AB - BACKGROUND: Chewing is a fundamental motor activity, but there is no specific assessment tool in Italian for paediatric rehabilitation. The Karaduman Chewing Performance Scale (KCPS) is a performance-based assessment tool that allow to classify chewing performance in childhood. OBJECTIVE: To translate, culturally adapt and assess reliability, criterion validity and cross-cultural validity of the KCPS into Italian in a paediatric population. METHODS: Following international guidelines, the KCPS was translated and culturally adapted into Italian. Inter-rater reliability was measured using the intraclass correlation coefficient (ICC), the criterion validity using the Pearson correlation coefficient comparing KCPS score with the Paediatric Screening-Priority Evaluation Dysphagia (PS-PED), and cross-cultural validity was examined across diagnostic groups. RESULTS: The study included 165 children with a mean age of 6.33 with different health conditions, namely autism spectrum disorder, cerebral palsy and genetic syndromes. The analysis revealed that KCPS was reliable measure with a ICC 0.93, and a moderate positive linear correlation with the PS-PED (Pearson 0.48) was found. In each diagnostic group, chewing performance disorders were found, highlighting specific characteristics. CONCLUSIONS: Despite limited sample in reliability analysis and the need of exploring the relationship with chewing abilities and severity of diseases, the KCPS was found a reliable and valid tool for determining the level of chewing performance in paediatric population. Now Italian clinicians can use it with more confidence in their clinical practice and research. CI - (c) 2024 John Wiley & Sons Ltd. FAU - Pizza, Francesca AU - Pizza F AD - Management and Diagnostic Innovations & Clinical Pathways Research Area, Neurorehabilitation and Adapted Physical Activity Day Hospital, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Tofani, Marco AU - Tofani M AUID- ORCID: 0000-0003-2071-4513 AD - Management and Diagnostic Innovations & Clinical Pathways Research Area, Medical Directorate, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. AD - Department of Life Sciences, Health and Allied Healthcare Professions Universita degli Studi "Link Campus University", Rome, Italy. FAU - Biondo, Giorgia AU - Biondo G AD - Management and Diagnostic Innovations & Clinical Pathways Research Area, Neurorehabilitation and Adapted Physical Activity Day Hospital, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Giordani, Carolina AU - Giordani C AD - Management and Diagnostic Innovations & Clinical Pathways Research Area, Neurorehabilitation and Adapted Physical Activity Day Hospital, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Murgioni, Cristiana AU - Murgioni C AD - Management and Diagnostic Innovations & Clinical Pathways Research Area, Neurorehabilitation and Adapted Physical Activity Day Hospital, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Raponi, Massimiliano AU - Raponi M AD - Management and Diagnostic Innovations & Clinical Pathways Research Area, Professional Development, Continuous Education and Research Service, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Della Bella, Gessica AU - Della Bella G AD - Management and Diagnostic Innovations & Clinical Pathways Research Area, Neurorehabilitation and Adapted Physical Activity Day Hospital, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Cerchiari, Antonella AU - Cerchiari A AD - Management and Diagnostic Innovations & Clinical Pathways Research Area, Neurorehabilitation and Adapted Physical Activity Day Hospital, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. LA - eng GR - This research was supported by the Italian Ministry of Health with "Current Research Funds"./ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study PL - England TA - J Eval Clin Pract JT - Journal of evaluation in clinical practice JID - 9609066 SB - IM MH - Humans MH - Italy MH - Child MH - *Mastication/physiology MH - Female MH - Male MH - Reproducibility of Results MH - Child, Preschool MH - *Cross-Cultural Comparison MH - Translations MH - Cerebral Palsy MH - Autism Spectrum Disorder MH - Adolescent MH - Deglutition Disorders/diagnosis MH - Psychometrics/methods OTO - NOTNLM OT - autism spectrum disorder OT - cerebral palsy OT - chewing OT - children OT - genetic syndrome OT - performance OT - rehabilitation OT - validation EDAT- 2024/12/20 06:23 MHDA- 2024/12/20 06:24 CRDT- 2024/12/20 05:03 PHST- 2024/11/04 00:00 [revised] PHST- 2024/06/27 00:00 [received] PHST- 2024/12/02 00:00 [accepted] PHST- 2024/12/20 06:24 [medline] PHST- 2024/12/20 06:23 [pubmed] PHST- 2024/12/20 05:03 [entrez] AID - 10.1111/jep.14283 [doi] PST - ppublish SO - J Eval Clin Pract. 2025 Feb;31(1):e14283. doi: 10.1111/jep.14283. PMID- 39703889 OWN - NLM STAT- MEDLINE DCOM- 20241220 LR - 20260823 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 13 DP - 2024 TI - About Your Child's Eating scale: a cross-cultural adaptation and validation of the questionnaire in the Greek language. PG - e87 LID - 10.1017/jns.2024.83 [doi] LID - e87 AB - Feeding is an interactive process between parents and children and is related to children's healthy nutrition, growth, and feelings about the child or parent. The effectiveness of the interaction between feeding and behaviour is strongly influenced by how well this reciprocal procedure is stimulated and supported. The current study aimed to cross-culturally adapt and validate the About Your Child's Eating (AYCE) questionnaire in its Greek language version for Greek-Cypriot parents and caregivers of children aged six months to 16 years with or without feeding and swallowing problems. One hundred Greek-Cypriot parents/caregivers of children with feeding and swallowing difficulties and 100 Greek-Cypriot parents/caregivers of children without feeding and swallowing difficulties participated in this study. This study was conducted at mainstream schools and private speech-language therapy clinics in Cyprus. According to WHO, the AYCE questionnaire was translated and culturally tailored for Greek speakers. The analysis revealed a statistically significant difference between the AYCE total mean scores of parents in the Typical Development of Feeding Behaviors group (c-TDFB) (M = 44.03, SD = 11.18) and parents in the Atypical Development of Feeding Behaviors group (c-ADFB) (M = 63.56, SD: 16.22) (P < 0.001), with c-ADFB scoring significantly higher. The overall evaluation of the scale yielded a Cronbach's alpha coefficient of 0.916. The validity of the AYCE questionnaire in Cyprus was also assessed. The findings demonstrate that the AYCE can be a beneficial tool for determining critical facets of the feeding parent-child interaction for preschool- and school-aged Greek-Cypriot children in Cyprus. CI - (c) The Author(s) 2024. FAU - Papaleontiou, Andri AU - Papaleontiou A AD - Department of Speech & Language Therapy, School of Health Sciences, University of Ioannina, Ioannina, Greece. FAU - Voniati, Louiza AU - Voniati L AD - Department of Health Sciences, Speech and Language Therapy, European University, Nicosia, Cyprus. FAU - Gryparis, Alexandros AU - Gryparis A AD - Department of Speech & Language Therapy, School of Health Sciences, University of Ioannina, Ioannina, Greece. FAU - Georgiou, Rafaella AU - Georgiou R AD - Department of Speech & Language Therapy, School of Health Sciences, University of Ioannina, Ioannina, Greece. FAU - Siafaka, Vassiliki AU - Siafaka V AD - Department of Speech & Language Therapy, School of Health Sciences, University of Ioannina, Ioannina, Greece. FAU - Tafiadis, Dionysios AU - Tafiadis D AD - Department of Speech & Language Therapy, School of Health Sciences, University of Ioannina, Ioannina, Greece. LA - eng PT - Journal Article PT - Validation Study DEP - 20241203 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 SB - IM MH - Humans MH - Surveys and Questionnaires MH - Child MH - Child, Preschool MH - Female MH - Male MH - *Feeding Behavior MH - Adolescent MH - Cyprus MH - Infant MH - *Cross-Cultural Comparison MH - *Language MH - *Parents MH - Greece MH - Reproducibility of Results MH - Caregivers MH - Translations PMC - PMC11658935 OTO - NOTNLM OT - About Your Child's Eating (AYCE) OT - Feeding behaviours OT - Greek-Cypriot parents/caregivers OT - Paediatric eating and feeding process OT - Parent/caregiver questionnaire COIS- The authors declare that they have no contending benefits or competing financial interests. EDAT- 2024/12/20 06:24 MHDA- 2024/12/20 06:25 PMCR- 2024/01/01 CRDT- 2024/12/20 04:17 PHST- 2024/06/06 00:00 [received] PHST- 2024/10/03 00:00 [revised] PHST- 2024/11/05 00:00 [accepted] PHST- 2024/12/20 06:25 [medline] PHST- 2024/12/20 06:24 [pubmed] PHST- 2024/12/20 04:17 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - S2048679024000831 [pii] AID - 10.1017/jns.2024.83 [doi] PST - epublish SO - J Nutr Sci. 2024 Dec 3;13:e87. doi: 10.1017/jns.2024.83. eCollection 2024. PMID- 39703523 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250104 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 11 DP - 2024 TI - Association of dietary inflammatory index and refractive status in American adolescents: NHANES 1999-2008. PG - 1511662 LID - 10.3389/fmed.2024.1511662 [doi] LID - 1511662 AB - BACKGROUND: Several nutrients have been found to be associated with the prevalence of myopia, and the role of dietary patterns in influencing myopia risk has recently garnered significant attention. We aim to explore the relationship between the Dietary Inflammatory Index (DII) and refractive status in adolescents. METHODS: Data from 7,331 participants were analyzed from the 2005-2008 US National Health and Nutrition Examination Survey (NHANES). Smooth curve fitting and linear regression analysis were used to explore both non-linear and linear relationships between DII and spherical equivalent refraction (SER). The threshold effect of DII on SER was analyzed using a two-piecewise linear regression model. RESULTS: DII was connected with a lower SER, indicating a shift toward myopia (beta: -0.0586; 95% CI: -0.1109 to -0.0063; p < 0.05). Compared to the first quartile, the third quartile (beta: -0.2512; 95% CI: -0.4952 to -0.0072; p < 0.05) and the fourth quartile (beta: -0.2905; 95% CI: -0.5030 to -0.0780; p < 0.01) were significantly associated with a lower SER. Smooth curve fitting revealed a non-linear relationship between DII and SER, with a turning point at 0.81. For DII values below 0.81, there was no significant association with SER (beta: -0.0450; 95% CI: -0.0272 to -0.1173; p > 0.05). However, for DII values >/=0.81, a significant association with lower SER was observed (beta: -0.1197; 95% CI: -1.1722 to -0.0672; p < 0.01). CONCLUSION: These findings indicate that a higher DII (>/=0.81) may contribute to the progression of myopia. This study highlights the potential for dietary recommendations in myopia prevention. Prospective studies are required to validate these findings and establish causal relationships. CI - Copyright (c) 2024 Chen, Li, Xu, Li, Guo, Miao, Wang and Huang. FAU - Chen, Xiaodong AU - Chen X AD - Department of Ophthalmology, Peking University People's Hospital, Eye Diseases and Optometry Institute, Beijing, China. AD - Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China. AD - College of Optometry, Peking University Health Science Center, Beijing, China. FAU - Li, Xuewei AU - Li X AD - Department of Ophthalmology, Peking University People's Hospital, Eye Diseases and Optometry Institute, Beijing, China. AD - Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China. AD - College of Optometry, Peking University Health Science Center, Beijing, China. AD - Institute of Medical Technology, Peking University Health Science Center, Beijing, China. FAU - Xu, Ningda AU - Xu N AD - Department of Ophthalmology, Peking University People's Hospital, Eye Diseases and Optometry Institute, Beijing, China. AD - Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China. AD - College of Optometry, Peking University Health Science Center, Beijing, China. AD - Shenzhen Eye Hospital, Shenzhen, Guangdong, China. FAU - Li, Jiarui AU - Li J AD - Department of Ophthalmology, Peking University People's Hospital, Eye Diseases and Optometry Institute, Beijing, China. AD - Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China. AD - College of Optometry, Peking University Health Science Center, Beijing, China. FAU - Guo, Qianwen AU - Guo Q AD - Department of Ophthalmology, Peking University People's Hospital, Eye Diseases and Optometry Institute, Beijing, China. AD - Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China. AD - College of Optometry, Peking University Health Science Center, Beijing, China. FAU - Miao, Heng AU - Miao H AD - Department of Ophthalmology, Peking University People's Hospital, Eye Diseases and Optometry Institute, Beijing, China. AD - Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China. AD - College of Optometry, Peking University Health Science Center, Beijing, China. FAU - Wang, Kai AU - Wang K AD - Department of Ophthalmology, Peking University People's Hospital, Eye Diseases and Optometry Institute, Beijing, China. AD - Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China. AD - College of Optometry, Peking University Health Science Center, Beijing, China. AD - Institute of Medical Technology, Peking University Health Science Center, Beijing, China. FAU - Huang, Lvzhen AU - Huang L AD - Department of Ophthalmology, Peking University People's Hospital, Eye Diseases and Optometry Institute, Beijing, China. AD - Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China. AD - College of Optometry, Peking University Health Science Center, Beijing, China. LA - eng PT - Journal Article DEP - 20241205 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC11655238 OTO - NOTNLM OT - NHANES OT - adolescents OT - dietary inflammatory potential OT - myopia OT - spherical equivalent COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/12/20 10:47 MHDA- 2024/12/20 10:48 PMCR- 2024/12/05 CRDT- 2024/12/20 04:09 PHST- 2024/10/15 00:00 [received] PHST- 2024/11/22 00:00 [accepted] PHST- 2024/12/20 10:48 [medline] PHST- 2024/12/20 10:47 [pubmed] PHST- 2024/12/20 04:09 [entrez] PHST- 2024/12/05 00:00 [pmc-release] AID - 10.3389/fmed.2024.1511662 [doi] PST - epublish SO - Front Med (Lausanne). 2024 Dec 5;11:1511662. doi: 10.3389/fmed.2024.1511662. eCollection 2024. PMID- 39702852 OWN - NLM STAT- MEDLINE DCOM- 20260122 LR - 20261009 IS - 1432-1971 (Electronic) IS - 0172-0643 (Linking) VI - 47 IP - 1 DP - 2026 Jan TI - Use of CRISP Modifiers for Adults Undergoing Cardiac Catheterization Procedures: A Single Center Experience. PG - 84-92 LID - 10.1007/s00246-024-03728-x [doi] AB - The Catheterization RISk Score for Pediatrics (CRISP) has been validated and widely adopted as a model to predict adverse outcomes. We sought to determine if the addition of three modifiers (NYHA Class > 2, prior sternotomies > 2, and BMI > 30) to the CRISP score would better predict adverse events (AE) in adults undergoing cardiac catheterization at our institution. All adults (> 18 years) who underwent cardiac catheterization at the Children's Hospital Colorado from November 2016 to November 2021 were included. Baseline and modified CRISP scores with adult modifiers and AEs were analyzed. Of a total of 401 cases, there were 27 AEs (6.7%). A higher CRISP score was associated with an increased risk of AEs (p = 0.004). A ROC analysis of the CRISP score gave a AUC of 66% with a cut-off point of 5.5 giving a sensitivity of 74% and specificity of 52%. The modifiers individually did not significantly correlate with AEs. Higher modified CRISP score was similarly associated with an increased risk of AEs (p = 0.01). ROC analysis for the modified CRISP score gave an AUC of 64%. A cut-off point of 6.5 gave the best result with a sensitivity of 59% and specificity of 61%. A modified CRISP score which included adult modifiers similarly predicts AEs in adults with congenital heart disease. These adult modifiers are easy to incorporate into the CRISP score. The CRISP score also predicted AEs in adults with congenital heart disease. CI - (c) 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Reynolds, Kathryn P AU - Reynolds KP AUID- ORCID: 0000-0002-8515-3617 AD - Heart Institute, Children's Hospital of Colorado, University of Colorado, Aurora, CO, USA. kpreynolds09@gmail.com. FAU - Mejia, Ernesto AU - Mejia E AD - Heart Institute, Children's Hospital of Colorado, University of Colorado, Aurora, CO, USA. FAU - Soszyn, Natalie AU - Soszyn N AD - Heart Institute, Children's Hospital of Colorado, University of Colorado, Aurora, CO, USA. FAU - Morgan, Gareth AU - Morgan G AD - Heart Institute, Children's Hospital of Colorado, University of Colorado, Aurora, CO, USA. FAU - Zablah, Jenny E AU - Zablah JE AD - Heart Institute, Children's Hospital of Colorado, University of Colorado, Aurora, CO, USA. LA - eng PT - Journal Article DEP - 20241219 PL - United States TA - Pediatr Cardiol JT - Pediatric cardiology JID - 8003849 SB - IM MH - Humans MH - *Cardiac Catheterization/adverse effects MH - Female MH - Male MH - Adult MH - Risk Assessment/methods MH - Retrospective Studies MH - ROC Curve MH - Middle Aged MH - Risk Factors MH - Young Adult MH - Adolescent OTO - NOTNLM OT - Adult congenital heart disease OT - Adverse events OT - Cardiac catheterization OT - Risk assessment COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2024/12/20 06:23 MHDA- 2026/01/22 13:30 CRDT- 2024/12/20 00:57 PHST- 2024/10/25 00:00 [received] PHST- 2024/12/01 00:00 [accepted] PHST- 2026/01/22 13:30 [medline] PHST- 2024/12/20 06:23 [pubmed] PHST- 2024/12/20 00:57 [entrez] AID - 10.1007/s00246-024-03728-x [pii] AID - 10.1007/s00246-024-03728-x [doi] PST - ppublish SO - Pediatr Cardiol. 2026 Jan;47(1):84-92. doi: 10.1007/s00246-024-03728-x. Epub 2024 Dec 19. PMID- 39702050 OWN - NLM STAT- MEDLINE DCOM- 20241220 LR - 20260428 IS - 1471-2261 (Electronic) IS - 1471-2261 (Linking) VI - 24 IP - 1 DP - 2024 Dec 20 TI - Using artificial intelligence to predict post-operative outcomes in congenital heart surgeries: a systematic review. PG - 718 LID - 10.1186/s12872-024-04336-6 [doi] LID - 718 AB - INTRODUCTION: Congenital heart disease (CHD) represents the most common group of congenital anomalies, constitutes a significant contributor to the burden of non-communicable diseases, highlighting the critical need for improved risk assessment tools. Artificial intelligence (AI) holds promise in enhancing outcome predictions for congenital cardiac surgery. This study aims to systematically review the utilization of AI in predicting post-operative outcomes in this population. METHODS: Following PRISMA guidelines, a comprehensive search of Pubmed, Scopus, and Web of Science databases was conducted. Two independent reviewers screened articles based on predefined criteria. Included studies focused on AI models predicting various post-operative outcomes in congenital heart surgery. RESULTS: The review included 35 articles, primarily published within the last four years, indicating growing interest in AI applications. Models predominantly targeted mortality and survival (n = 16), prolonged length of hospital or ICU stay (n = 7), postoperative complications (n = 6), prolonged mechanical ventilatory support time (n = 4), with additional focus on specific outcomes such as peri-ventricular leucomalacia (n = 2) and malnutrition (n = 1). Performance metrics, such as area under the curve (AUC), ranged from 0.52 to 0.997. Notably, these AI models consistently outperformed traditional risk stratification categories. For instance, in assessing the risk of morbidity and mortality, the AI models demonstrated superior performance compared to conventional methods. CONCLUSION: AI-driven prediction models show significant promise in improving outcome predictions for congenital heart surgery. They surpass traditional risk prediction tools not only in immediate postoperative risks but also in long-term outcomes such as 1-year survival and malnutrition. Further studies with robust external validation are necessary to assess the practical applicability of these models in clinical settings. The protocol of this review was prospectively registered on PROSPERO (CRD42024550942). CI - (c) 2024. The Author(s). FAU - Mohammadi, Ida AU - Mohammadi I AD - Cardiovascular Surgery Research and Development Committee, Iran University of Medical Sciences (IUMS), PO box 14665-354, Tehran, Iran. FAU - Rajai Firouzabadi, Shahryar AU - Rajai Firouzabadi S AD - Cardiovascular Surgery Research and Development Committee, Iran University of Medical Sciences (IUMS), PO box 14665-354, Tehran, Iran. AD - Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Teheran, Iran. FAU - Hosseinpour, Melika AU - Hosseinpour M AD - Cardiovascular Surgery Research and Development Committee, Iran University of Medical Sciences (IUMS), PO box 14665-354, Tehran, Iran. FAU - Akhlaghpasand, Mohammadhosein AU - Akhlaghpasand M AD - Cardiovascular Surgery Research and Development Committee, Iran University of Medical Sciences (IUMS), PO box 14665-354, Tehran, Iran. Akhlaghpasandm@yahoo.com. AD - Department of Surgery, Surgery Research Center, School of Medicine, Rasool-E Akram Hospital, Iran University of Medical Sciences, Tehran, Iran. Akhlaghpasandm@yahoo.com. FAU - Hajikarimloo, Bardia AU - Hajikarimloo B AD - Cardiovascular Surgery Research and Development Committee, Iran University of Medical Sciences (IUMS), PO box 14665-354, Tehran, Iran. FAU - Zeraatian-Nejad, Sam AU - Zeraatian-Nejad S AD - Cardiovascular Surgery Research and Development Committee, Iran University of Medical Sciences (IUMS), PO box 14665-354, Tehran, Iran. AD - Department of Surgery, Surgery Research Center, School of Medicine, Rasool-E Akram Hospital, Iran University of Medical Sciences, Tehran, Iran. FAU - Sardari Nia, Peyman AU - Sardari Nia P AD - Department of Cardiothoracic Surgery, Maastricht University Medical Centre, Maastricht, Netherlands. AD - Foundation Heart Team Academy, Maastricht, the Netherlands. LA - eng PT - Journal Article PT - Systematic Review DEP - 20241220 PL - England TA - BMC Cardiovasc Disord JT - BMC cardiovascular disorders JID - 100968539 SB - IM EIN - BMC Cardiovasc Disord. 2025 Jan 10;25(1):14. doi: 10.1186/s12872-025-04479-0. PMID: 39794716 MH - Humans MH - *Heart Defects, Congenital/surgery/mortality MH - Risk Assessment MH - *Cardiac Surgical Procedures/adverse effects/mortality MH - *Postoperative Complications/etiology/mortality MH - Treatment Outcome MH - Risk Factors MH - *Artificial Intelligence MH - *Predictive Value of Tests MH - Infant, Newborn MH - Infant MH - Female MH - Child MH - Male MH - Child, Preschool MH - Time Factors MH - Adolescent MH - Decision Support Techniques MH - Adult MH - Young Adult PMC - PMC11660586 OTO - NOTNLM OT - Artificial Intelligence OT - Cardiac Surgery OT - Congenital Heart Defects OT - Machine Learning COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2024/12/20 06:24 MHDA- 2024/12/20 06:25 PMCR- 2024/12/20 CRDT- 2024/12/20 00:09 PHST- 2024/07/01 00:00 [received] PHST- 2024/11/11 00:00 [accepted] PHST- 2024/12/20 06:25 [medline] PHST- 2024/12/20 06:24 [pubmed] PHST- 2024/12/20 00:09 [entrez] PHST- 2024/12/20 00:00 [pmc-release] AID - 10.1186/s12872-024-04336-6 [pii] AID - 4336 [pii] AID - 10.1186/s12872-024-04336-6 [doi] PST - epublish SO - BMC Cardiovasc Disord. 2024 Dec 20;24(1):718. doi: 10.1186/s12872-024-04336-6. PMID- 39700199 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250104 IS - 2767-3375 (Electronic) IS - 2767-3375 (Linking) VI - 4 IP - 12 DP - 2024 TI - Methods for measuring body composition in Zambian adolescents living with HIV. PG - e0003200 LID - 10.1371/journal.pgph.0003200 [doi] LID - e0003200 AB - Assessment of body composition can be useful in managing many clinical or public health conditions, including HIV. Most people living with HIV infection are in Africa where clinics may lack equipment, utilities or staff time for optimal body composition assessment. Thus, it is important to determine whether less expensive and more available and scalable methods can provide adequate information. We estimated body composition of 420 perinatally HIV-infected Zambian adolescents, aged 11-19 years, using dual-energy X-ray absorptiometry (DXA), bioelectrical impedance (BIA) and anthropometry: body mass index (BMI), waist circumference, and subscapular and suprailiac skinfolds. Data were converted to internal population Z-scores in order to compare measures. BIA and DXA were compared for total fat and fat-free mass, BMI was compared to DXA fat mass, and waist circumference and skinfolds were compared to DXA trunk (central) fat. Neither anthropometry nor BIA adequately reflected total fat or trunk fat as measured by DXA. Although mean bias was generally small, especially for females, the limits of agreement were wide for all comparisons. In addition, for central fat in males, the bias was larger at higher mean Z-score values. BMI had similar agreement with DXA fat mass, as did BIA in females, though not males. We conclude that, because of wide limits of agreement and bias in some measures, none of the simpler methods examined are adequate for assessing longitudinal changes in body composition in order to monitor children's health. However, where BIA is available and DXA is not, BIA may still be able to describe broad trends in body composition of African adolescents living with HIV. CI - Copyright: (c) 2024 Filteau et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Filteau, Suzanne AU - Filteau S AUID- ORCID: 0000-0002-1119-6825 AD - Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom. FAU - Chisenga, Molly AU - Chisenga M AD - University Teaching Hospital, Lusaka, Zambia. FAU - Namunkonda, Cassandra AU - Namunkonda C AD - University Teaching Hospital, Lusaka, Zambia. FAU - Mukwasi-Kahari, Cynthia AU - Mukwasi-Kahari C AUID- ORCID: 0000-0002-7289-5152 AD - Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom. AD - The Health Research Unit (THRU-ZIM), Biomedical Research and Training Institute, Harare, Zimbabwe. FAU - Kasonka, Lackson AU - Kasonka L AUID- ORCID: 0000-0001-7525-2382 AD - University Teaching Hospital, Lusaka, Zambia. FAU - Simms, Victoria AU - Simms V AUID- ORCID: 0000-0002-4897-458X AD - Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom. FAU - Gregson, Celia L AU - Gregson CL AD - Musculoskeletal Research Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom. FAU - Wells, Jonathan C AU - Wells JC AUID- ORCID: 0000-0003-0411-8025 AD - Institute of Child Health, University College London, London, United Kingdom. LA - eng PT - Journal Article DEP - 20241219 PL - United States TA - PLOS Glob Public Health JT - PLOS global public health JID - 9918283779606676 PMC - PMC11658486 COIS- The authors have declared that no competing interests exist. EDAT- 2024/12/19 18:21 MHDA- 2024/12/19 18:22 PMCR- 2024/12/19 CRDT- 2024/12/19 13:52 PHST- 2024/02/22 00:00 [received] PHST- 2024/11/04 00:00 [accepted] PHST- 2024/12/19 18:22 [medline] PHST- 2024/12/19 18:21 [pubmed] PHST- 2024/12/19 13:52 [entrez] PHST- 2024/12/19 00:00 [pmc-release] AID - PGPH-D-24-00332 [pii] AID - 10.1371/journal.pgph.0003200 [doi] PST - epublish SO - PLOS Glob Public Health. 2024 Dec 19;4(12):e0003200. doi: 10.1371/journal.pgph.0003200. eCollection 2024. PMID- 39700117 OWN - NLM STAT- MEDLINE DCOM- 20241219 LR - 20260717 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 12 DP - 2024 TI - The parkour tic-tac action versus the drop jump as part of complex training within the strength and conditioning programme of highly-trained youth basketball players. PG - e0315013 LID - 10.1371/journal.pone.0315013 [doi] LID - e0315013 AB - This study aimed to examine the effects of two different complex training protocols on physical performance in highly-trained youth basketball players. Fourteen adolescent players participated in twice-weekly sessions over eight weeks, following either the Drop Jump protocol (n = 7) or the Tic-tac protocol (n = 7), performing 1-3 sets of 8-9 exercises. Physical performance was assessed before and after the intervention using jumping tests (CMJ, squat, 10-5 hop jumps), change-of-direction speed (5-10-5), sprinting (0-20 meters), and muscular strength (isometric midthigh pull) tests. The intraclass correlation coefficient of within subjects measures was 0.95. Results showed no significant fixed effects for group or time on performance variables (p > 0.05), with greater variance attributed to measurements rather than group differences. The interindividual response to training was highly variable, contingent on the performance outcome. These findings suggest that the parkour-based Tic-tac protocol can be included in strength and conditioning programs for youth basketball players to enhance sport-specific actions. However, to improve physical performance in young team-sport athletes, it is crucial to address the individual needs of each athlete. This includes acknowledging the highly individualised responses to training stimuli. CI - Copyright: (c) 2024 Williams et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Williams, Mark David AU - Williams MD AUID- ORCID: 0000-0002-2301-0047 AD - School of Sport, Rehabilitation and Exercise Sciences, University of Essex, Colchester, Essex, United Kingdom. AD - School of Psychology and Sport Science, Anglia Ruskin University, Cambridge, Cambridgeshire, United Kingdom. FAU - Arede, Jorge AU - Arede J AD - School of Education, Polytechnic Institute of Viseu, Viseu, Portugal. AD - Department of Sports Sciences, Exercise and Health, University of Tras-os-Montes and Alto Douro, Vila Real, Portugal. AD - Research Center in Sports Sciences, Health Sciences and Human Development, CIDESD, Vila Real, Portugal. FAU - Griggs, Aiden AU - Griggs A AD - School of Sport, Rehabilitation and Exercise Sciences, University of Essex, Colchester, Essex, United Kingdom. FAU - Moran, Jason AU - Moran J AD - School of Sport, Rehabilitation and Exercise Sciences, University of Essex, Colchester, Essex, United Kingdom. LA - eng PT - Journal Article DEP - 20241219 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Basketball/physiology MH - Adolescent MH - Male MH - *Muscle Strength/physiology MH - *Athletic Performance/physiology MH - *Resistance Training/methods MH - Athletes PMC - PMC11658586 COIS- The authors have declared that no competing interests exist. EDAT- 2024/12/19 18:22 MHDA- 2024/12/19 18:23 PMCR- 2024/12/19 CRDT- 2024/12/19 13:42 PHST- 2024/09/02 00:00 [received] PHST- 2024/11/20 00:00 [accepted] PHST- 2024/12/19 18:23 [medline] PHST- 2024/12/19 18:22 [pubmed] PHST- 2024/12/19 13:42 [entrez] PHST- 2024/12/19 00:00 [pmc-release] AID - PONE-D-24-36893 [pii] AID - 10.1371/journal.pone.0315013 [doi] PST - epublish SO - PLoS One. 2024 Dec 19;19(12):e0315013. doi: 10.1371/journal.pone.0315013. eCollection 2024. PMID- 39696159 OWN - NLM STAT- MEDLINE DCOM- 20241219 LR - 20250104 IS - 1472-6823 (Electronic) IS - 1472-6823 (Linking) VI - 24 IP - 1 DP - 2024 Dec 18 TI - Higher body roundness index (BRI) increases infertility among U.S. women aged 18-45 years. PG - 266 LID - 10.1186/s12902-024-01799-8 [doi] LID - 266 AB - OBJECTIVE: Infertility is associated with obesity. The Body Roundness Index (BRI) is a body measurement index related to obesity that more accurately assesses body and visceral fat levels. However, the relationship between BRI and infertility remains unclear. Therefore, this study aims to determine the relationship between BRI and infertility. METHODS: This study utilized data from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2018 and included 3,528 women aged 18-45 years. Multivariate logistic regression was employed to investigate the association between BRI and infertility. Restricted cubic spline (RCS) analysis explored the linear or non-linear relationship between BRI and infertility. Interaction analyses were conducted on subgroups to validate the findings. To verify the robustness of the results, we performed several sensitivity analyses, including propensity score matching(PSM) and multiple imputations for missing data. Furthermore, the predictive capabilities of various anthropometric indices-including BRI, weight-adjusted waist index (WWI), body mass index (BMI), and weight-on infertility incidence were assessed using Receiver Operating Characteristic (ROC) curve analysis. RESULTS: There was a significant positive association between BRI and infertility. After adjusting for covariates, for each unit increase in BRI, there was a 12% increase in the probability of infertility (P < 0.001). This positive correlation persisted when BRI was categorized into quartiles. Moreover, as BRI increased, there was a trend towards higher infertility prevalence (P for trend < 0.001). The dose-response curve indicated a linear association between BRI and infertility, with higher BRI associated with higher infertility risk. The correlation between BRI and infertility persisted in subgroup analysis and multiple imputations. The ROC curve analysis revealed that BRI had a superior predictive capability compared to traditional obesity indices, with an area under the curve (AUC) of 0.618 (95% CI, 0.588-0.648). CONCLUSION: The results of this study show a strong positive correlation between BRI and the prevalence of infertility. CLINICAL TRIAL NUMBER: Not Applicable. CI - (c) 2024. The Author(s). FAU - Gong, Hongyang AU - Gong H AD - Department of Oncology Surgery, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, No.102 Gudong Road, Gulou District, Fuzhou City, Fujian Province, 350001, China. AD - Department of Physiology, College of Medicine, Chosun University, Gwangju, Korea. FAU - Duan, Shuqin AU - Duan S AD - Graduate School of Jilin University, Changchun City, China. FAU - Choi, Seok AU - Choi S AD - Department of Physiology, College of Medicine, Chosun University, Gwangju, Korea. FAU - Huang, Shaoqun AU - Huang S AD - Department of Oncology Surgery, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, No.102 Gudong Road, Gulou District, Fuzhou City, Fujian Province, 350001, China. sqhuang@fjtcm.edu.cn. LA - eng PT - Journal Article DEP - 20241218 PL - England TA - BMC Endocr Disord JT - BMC endocrine disorders JID - 101088676 SB - IM MH - Humans MH - Female MH - Adult MH - Adolescent MH - Young Adult MH - *Infertility, Female/epidemiology MH - United States/epidemiology MH - *Body Mass Index MH - Middle Aged MH - *Obesity/epidemiology/complications MH - Nutrition Surveys MH - Prognosis MH - Cross-Sectional Studies PMC - PMC11654071 OTO - NOTNLM OT - Association OT - Body roundness index OT - Infertility OT - NHANES OT - U.S. women COIS- Declarations. Ethics approval and consent to participate: The data survey conducted by NHANES has been approved by the NCHS Research Ethics Review Board (ERB). All information from the NHANES program is available and free for the public, so an individual investigator was not necessary to obtain approval from the institution's internal ethics review board. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. EDAT- 2024/12/19 06:22 MHDA- 2024/12/19 06:23 PMCR- 2024/12/18 CRDT- 2024/12/19 00:31 PHST- 2024/07/28 00:00 [received] PHST- 2024/12/03 00:00 [accepted] PHST- 2024/12/19 06:23 [medline] PHST- 2024/12/19 06:22 [pubmed] PHST- 2024/12/19 00:31 [entrez] PHST- 2024/12/18 00:00 [pmc-release] AID - 10.1186/s12902-024-01799-8 [pii] AID - 1799 [pii] AID - 10.1186/s12902-024-01799-8 [doi] PST - epublish SO - BMC Endocr Disord. 2024 Dec 18;24(1):266. doi: 10.1186/s12902-024-01799-8. PMID- 39693931 OWN - NLM STAT- MEDLINE DCOM- 20250428 LR - 20250728 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 131 DP - 2025 Mar TI - Tri-Ponderal Mass Index-A reliable anthropometric index for early screening of adolescent obesity in a school-based setting: A cross-sectional study. PG - 112639 LID - S0899-9007(24)00288-0 [pii] LID - 10.1016/j.nut.2024.112639 [doi] AB - OBJECTIVE: This study was designed to examine the reliability of the Tri-Ponderal Mass Index (TMI) for early screening of adolescent obesity compared with anthropometric measures such as hip circumference, neck circumference, waist circumference, waist-height ratio, waist-hip ratio, and body mass index. METHODS: A school-based, cross-sectional study was conducted between July and December 2019 among 1101 school-going adolescents (both sexes) aged 12 to 17 years, in Rudrapur, Uttarakhand, India. Anthropometric measurements were collected using well-calibrated equipment, and age- and sex-specific BMI percentile cutoff values recommended by the Indian Academy of Pediatrics were used to define overweight and obesity. Statistical analysis was done using SPSS software version 16.0. Receiver operating characteristic curve analysis was conducted, and optimal cutoff values for anthropometric measurements were determined using the Youden Index (sensitivity + specificity - 1). RESULTS: Of 1101 study participants, 71.5% (n = 787) and 28.5% (n = 314) were males and females, respectively. The prevalences of overweight and obesity were 10.4% and 4.1%, respectively. Receiver operating characteristic curve analysis was conducted and TMI exhibited the highest Youden Index both in terms of overweight (0.835) and obesity (0.869) among adolescents. The optimal TMI cutoff values for overweight and obese males and females were >12 kg/m(3) and >14 kg/m(3) and >13 kg/m(3) and >16 kg/m(3), respectively. The TMI demonstrated superior predictive capacity for early screening of adolescent obesity, as indicated by high discriminative power, sensitivity, and specificity. CONCLUSIONS: The TMI can be used as a simple, reliable tool for early screening of overweight and obesity among adolescents. CI - Copyright (c) 2024 Elsevier Inc. All rights reserved. FAU - Bharti, Anugya AU - Bharti A AD - Department of Food Science and Nutrition, GB Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, India. FAU - Kushwaha, Archana AU - Kushwaha A AD - Department of Food Science and Nutrition, GB Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, India. Electronic address: archkush08@gmail.com. FAU - Yadav, Surabhi Singh AU - Yadav SS AD - Symbiosis School of Culinary Arts and Nutritional Sciences (SSCANS), Symbiosis International (Deemed University) (SIU), Lavale, Pune, India. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241120 PL - United States TA - Nutrition JT - Nutrition (Burbank, Los Angeles County, Calif.) JID - 8802712 SB - IM MH - Humans MH - Male MH - Female MH - Cross-Sectional Studies MH - Adolescent MH - India/epidemiology MH - Child MH - *Body Mass Index MH - *Pediatric Obesity/diagnosis/epidemiology MH - Reproducibility of Results MH - *Mass Screening/methods MH - *Anthropometry/methods MH - Waist Circumference MH - ROC Curve MH - Prevalence MH - Schools MH - Sensitivity and Specificity MH - Waist-Hip Ratio OTO - NOTNLM OT - Adolescent OT - Obesity OT - Receiver operating characteristic curve analysis OT - Screening OT - Tri-Ponderal Mass Index COIS- Declaration of competing interest The authors declare the following financial interests and/or personal relationships that may be considered as potential competing interests: Anugya Bharti reports financial support was provided by The University Grants Commission, India. The other authors declare no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/12/19 00:20 MHDA- 2025/02/23 00:42 CRDT- 2024/12/18 18:10 PHST- 2024/06/01 00:00 [received] PHST- 2024/10/25 00:00 [revised] PHST- 2024/11/10 00:00 [accepted] PHST- 2025/02/23 00:42 [medline] PHST- 2024/12/19 00:20 [pubmed] PHST- 2024/12/18 18:10 [entrez] AID - S0899-9007(24)00288-0 [pii] AID - 10.1016/j.nut.2024.112639 [doi] PST - ppublish SO - Nutrition. 2025 Mar;131:112639. doi: 10.1016/j.nut.2024.112639. Epub 2024 Nov 20. PMID- 39693723 OWN - NLM STAT- MEDLINE DCOM- 20250428 LR - 20250519 IS - 1872-8464 (Electronic) IS - 0165-5876 (Linking) VI - 188 DP - 2025 Jan TI - Vomer-to-nasopharyngeal widths and post-adenoidectomy outcomes in children: A prospective blinded study. PG - 112193 LID - S0165-5876(24)00347-1 [pii] LID - 10.1016/j.ijporl.2024.112193 [doi] AB - OBJECTIVES: The vomer is an essential component of the nasopharynx. Although variations in vomer width(VW) and nasopharyngeal width(NW) can be observed, their clinical significance on post-adenoidectomy outcomes in children with sleep-disordered breathing and obstructive sleep apnea(SDB-OSA) remains uncertain. The primary outcome was to investigate the association between VW and post-adenoidectomy clinical improvement. Secondary outcomes were to investigate the variability and interplay between VW and NW. METHODS: This prospective, blinded cohort study was conducted at a tertiary hospital between 6/2022 and 7/2023. Children who underwent adenoidectomy for SDB-OSA were included. VW and NW were measured using a transoral endoscope. A calibrated ruler was positioned at the inferior aspect of the vomer for direct visualization, and the NW was calculated as the distance between the medial edges of the torus tubarius. Clinical improvement was collected using the OSA-18 survey. RESULTS: Of the 29 children (mean age:3.5 years, IQR: 2-4, 16[55 %] males), 26(89.6 %) showed a clinical improvement 1-month post-adenoidectomy (DeltaOSA-18 score: 24.6,95 % confidence interval: 31-(-14),p = 0.001). The mean VW was 3.88 mm (IQR: 3-4), and the mean NW was 13.76 mm (IQR:13-14). In the univariable analysis, clinical improvement was associated with age <3 years(p = 0.05), non-obese children(p = 0.01), large adenoids(p = 0.01), preoperative OSA-18 score>60(p = 0.05), and lower VW/NW(p = 0.013). The odds ratio for clinical improvement was decreased by 1.08 for each 0.01 increase in VW/NW (95%CI:1.05-1.11,p = 0.01). CONCLUSIONS: Lower VW/NW were associated with better clinical outcome 1-month post-adenoidectomy. Further randomized, prospective studies are needed to validate these findings and and explore whether interventions in this area could serve as a potential therapeutic target. CI - Copyright (c) 2024 Elsevier B.V. All rights reserved. FAU - Noy, Roee AU - Noy R AD - Department of Otolaryngology-Head and Neck Surgery, Rambam Health Care Campus, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel. Electronic address: roeenoy@gmail.com. FAU - Cohen, Jacob T AU - Cohen JT AD - Department of Otolaryngology-Head and Neck Surgery, Rambam Health Care Campus, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel. FAU - Gordin, Arie AU - Gordin A AD - Department of Otolaryngology-Head and Neck Surgery, Rambam Health Care Campus, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel. LA - eng PT - Journal Article DEP - 20241210 PL - Ireland TA - Int J Pediatr Otorhinolaryngol JT - International journal of pediatric otorhinolaryngology JID - 8003603 SB - IM MH - Humans MH - Male MH - Prospective Studies MH - Female MH - *Adenoidectomy/methods MH - Child, Preschool MH - Treatment Outcome MH - *Nasopharynx/anatomy & histology/pathology MH - *Sleep Apnea, Obstructive/surgery MH - *Sleep Apnea Syndromes/surgery MH - Child MH - Single-Blind Method OTO - NOTNLM OT - Adenoidectomy OT - Choana OT - Nasopharynx OT - Obstructive sleep apnea OT - Pediatric otolaryngology OT - Sleep-disordered breathing OT - Vomer COIS- Declaration of competing interest The authors have no relevant financial or nonfinancial interests to disclose. EDAT- 2024/12/19 00:20 MHDA- 2025/01/25 13:52 CRDT- 2024/12/18 18:02 PHST- 2024/08/25 00:00 [received] PHST- 2024/12/03 00:00 [revised] PHST- 2024/12/08 00:00 [accepted] PHST- 2025/01/25 13:52 [medline] PHST- 2024/12/19 00:20 [pubmed] PHST- 2024/12/18 18:02 [entrez] AID - S0165-5876(24)00347-1 [pii] AID - 10.1016/j.ijporl.2024.112193 [doi] PST - ppublish SO - Int J Pediatr Otorhinolaryngol. 2025 Jan;188:112193. doi: 10.1016/j.ijporl.2024.112193. Epub 2024 Dec 10. PMID- 39690980 OWN - NLM STAT- MEDLINE DCOM- 20250825 LR - 20250829 IS - 1945-7197 (Electronic) IS - 0021-972X (Print) IS - 0021-972X (Linking) VI - 110 IP - 9 DP - 2025 Aug 7 TI - Adult-based Genetic Risk Scores for Insulin Resistance Associate With Cardiometabolic Traits in Children and Adolescents. PG - 2645-2654 LID - 10.1210/clinem/dgae882 [doi] AB - CONTEXT: Insulin resistance (IR) is a key factor in the development of cardiometabolic diseases. While genetic risk scores (GRSs) for IR have been developed and validated in adult populations, it is unclear if they can be used for risk assessment in youth. OBJECTIVE: Our objective was to investigate whether adult-derived GRSs for IR associate with cardiometabolic traits in children and adolescents. METHODS: We studied a group of children and adolescents with obesity (n = 1680) and a group without obesity (n = 1804). We constructed 3 GRSs based on fasting (IR-GRS27), oral glucose tolerance test (IR-GRS8), and IR-related phenotypes (IR-GRS51) from previous genome-wide association studies. Using an additive genetic model, we calculated weighted GRSs and analyzed their associations with cardiometabolic traits using linear and logistic regression models. RESULTS: The IR-GRS27 was associated with higher serum concentrations of fasting insulin, C-peptide, triglycerides (TG), gamma-glutamyl transferase and alanine aminotransferase (ALT), and homeostatic model assessment of insulin resistance. The IR-GRS27 was furthermore associated with a higher prevalence of IR and ALT. IR-GRS51 was associated with higher TG and lower high-density lipoprotein cholesterol, while IR-GRS8 associated with lower total cholesterol, low-density lipoprotein cholesterol, and increased ALT. IR-GRS27 and IR-GRS8 were additionally associated with a higher prevalence of IR and steatotic liver disease, respectively. CONCLUSION: Adult-derived GRSs for IR are significantly associated with cardiometabolic traits in children and adolescents. If validated in independent study samples, our findings suggest the contribution of adult-based GRSs in assessing IR-related cardiometabolic risk in youth. CI - (c) The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society. FAU - Suleman, Sufyan AU - Suleman S AUID- ORCID: 0000-0001-6612-6915 AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark. AD - Department of Biomedicine, Human Genetics, Aarhus University, Aarhus 8000, Denmark. FAU - Huang, Yun AU - Huang Y AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark. FAU - Jensen, Rasmus Tanderup AU - Jensen RT AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark. FAU - Poggi, Axel Illeris AU - Poggi AI AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark. AD - The Children's Obesity Clinic, accredited European Centre for Obesity Management, Department of Paediatrics, Copenhagen University Hospital Holbaek, Holbaek 4300, Denmark. FAU - Christensen, Sara Bech AU - Christensen SB AD - The Children's Obesity Clinic, accredited European Centre for Obesity Management, Department of Paediatrics, Copenhagen University Hospital Holbaek, Holbaek 4300, Denmark. FAU - Fraulund, Maria Martens AU - Fraulund MM AD - The Children's Obesity Clinic, accredited European Centre for Obesity Management, Department of Paediatrics, Copenhagen University Hospital Holbaek, Holbaek 4300, Denmark. FAU - Anderson, Louise Volund AU - Anderson LV AD - The Children's Obesity Clinic, accredited European Centre for Obesity Management, Department of Paediatrics, Copenhagen University Hospital Holbaek, Holbaek 4300, Denmark. FAU - Stinson, Sara Elizabeth AU - Stinson SE AUID- ORCID: 0000-0002-1491-9179 AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark. AD - Section for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital, Oslo 0424, Norway. FAU - Fonvig, Cilius Esmann AU - Fonvig CE AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark. AD - The Children's Obesity Clinic, accredited European Centre for Obesity Management, Department of Paediatrics, Copenhagen University Hospital Holbaek, Holbaek 4300, Denmark. AD - Department of Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark. FAU - Pedersen, Oluf AU - Pedersen O AUID- ORCID: 0000-0002-3321-3972 AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark. AD - Center for Clinical Metabolic Research, Herlev-Gentofte Hospital, Copenhagen 2820, Denmark. FAU - Holm, Jens-Christian AU - Holm JC AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark. AD - The Children's Obesity Clinic, accredited European Centre for Obesity Management, Department of Paediatrics, Copenhagen University Hospital Holbaek, Holbaek 4300, Denmark. AD - Department of Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark. FAU - Hansen, Torben AU - Hansen T AUID- ORCID: 0000-0001-8748-3831 AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark. FAU - Grarup, Niels AU - Grarup N AUID- ORCID: 0000-0001-5526-1070 AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark. LA - eng GR - 1030-00280B/Independent Research Fund Denmark/ GR - NNF18CC0033668/The Novo Nordisk Foundation Copenhagen Bioscience PhD Programme/ GR - NNF18CC0034900/Novo Nordisk Foundation/ GR - NNF23SA0084103/Novo Nordisk Foundation/ PT - Journal Article PL - United States TA - J Clin Endocrinol Metab JT - The Journal of clinical endocrinology and metabolism JID - 0375362 SB - IM MH - Humans MH - *Insulin Resistance/genetics MH - Adolescent MH - Child MH - Female MH - Male MH - Adult MH - *Genetic Predisposition to Disease MH - Genome-Wide Association Study MH - Glucose Tolerance Test MH - *Cardiovascular Diseases/genetics/epidemiology MH - Risk Assessment MH - Cardiometabolic Risk Factors MH - *Pediatric Obesity/genetics/complications MH - Polymorphism, Single Nucleotide MH - Risk Factors MH - Young Adult MH - Phenotype MH - Genetic Risk Score PMC - PMC12342385 OTO - NOTNLM OT - adiposity OT - childhood obesity OT - genetic predisposition OT - metabolic disorders OT - overweight EDAT- 2024/12/18 11:32 MHDA- 2025/09/08 07:43 PMCR- 2024/12/18 CRDT- 2024/12/18 03:42 PHST- 2024/09/26 00:00 [received] PHST- 2025/09/08 07:43 [medline] PHST- 2024/12/18 11:32 [pubmed] PHST- 2024/12/18 03:42 [entrez] PHST- 2024/12/18 00:00 [pmc-release] AID - 7927383 [pii] AID - dgae882 [pii] AID - 10.1210/clinem/dgae882 [doi] PST - ppublish SO - J Clin Endocrinol Metab. 2025 Aug 7;110(9):2645-2654. doi: 10.1210/clinem/dgae882. PMID- 39688884 OWN - NLM STAT- MEDLINE DCOM- 20241217 LR - 20260628 IS - 2292-9495 (Electronic) IS - 2292-9495 (Linking) VI - 11 DP - 2024 Dec 17 TI - Stunting Super App as an Effort Toward Stunting Management in Indonesia: Delphi and Pilot Study. PG - e54862 LID - 10.2196/54862 [doi] LID - e54862 AB - BACKGROUND: Currently, 30 million children are experiencing acute malnutrition, and 8 million children are severely underweight. OBJECTIVE: This study aimed to develop a stunting super app, a one-stop app designed to prevent and manage stunting in Indonesia. METHODS: This study consisted of three stages. Stage 1 used a 3-round Delphi study involving 12 experts. In stage 2, 4 experts and a parent of children with stunted growth created an Android app containing stunting educational materials. In stage 3, a pilot study involving a control group was conducted to evaluate parents' knowledge about stunting prevention through the app and standard interventions. RESULTS: In the Delphi study, 11 consensus statements were extracted; arranged in three major themes, including maternal health education, child health education, and environmental education; and applied in the form of the Sistem Evaluasi Kesehatan Anak Tumbuh Ideal (SEHATI) app. This app was assessed using a content validity index, with a cumulative agreement of >/=80% among the 5 individuals. The pilot study showed an increase in the knowledge of mothers of toddlers with stunted growth before and after the educational intervention (P=.001). CONCLUSIONS: The SEHATI app provides educational content on stunting prevention that can increase the knowledge of mothers of toddlers with stunted growth. CI - (c) Kadek Ayu Erika, Nur Fadilah, Aulia Insani Latif, Nurhikmawaty Hasbiah, Aidah Juliaty, Harun Achmad, Anugrayani Bustamin. Originally published in JMIR Human Factors (https://humanfactors.jmir.org). FAU - Erika, Kadek Ayu AU - Erika KA AUID- ORCID: 0000-0001-6875-5264 AD - Faculty of Nursing, Hasanuddin University, Jl. Perintis Kemerdekaan Kampus Tamalanrea Km.10, Makassar, 90245, Indonesia, 62 81342129855. FAU - Fadilah, Nur AU - Fadilah N AUID- ORCID: 0000-0002-5384-1589 AD - Faculty of Nursing, Hasanuddin University, Jl. Perintis Kemerdekaan Kampus Tamalanrea Km.10, Makassar, 90245, Indonesia, 62 81342129855. FAU - Latif, Aulia Insani AU - Latif AI AUID- ORCID: 0000-0002-3987-3736 AD - Faculty of Nursing, Hasanuddin University, Jl. Perintis Kemerdekaan Kampus Tamalanrea Km.10, Makassar, 90245, Indonesia, 62 81342129855. FAU - Hasbiah, Nurhikmawaty AU - Hasbiah N AUID- ORCID: 0000-0002-2148-4599 AD - Faculty of Nursing, Hasanuddin University, Jl. Perintis Kemerdekaan Kampus Tamalanrea Km.10, Makassar, 90245, Indonesia, 62 81342129855. FAU - Juliaty, Aidah AU - Juliaty A AUID- ORCID: 0000-0001-5848-3146 AD - Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. FAU - Achmad, Harun AU - Achmad H AUID- ORCID: 0000-0003-3124-2064 AD - Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia. FAU - Bustamin, Anugrayani AU - Bustamin A AUID- ORCID: 0000-0001-7811-0507 AD - Faculty of Engineering, Hasanuddin University, Makassar, Indonesia. LA - eng PT - Journal Article DEP - 20241217 PL - Canada TA - JMIR Hum Factors JT - JMIR human factors JID - 101666561 SB - IM MH - Humans MH - Pilot Projects MH - Indonesia/epidemiology MH - *Growth Disorders/prevention & control/epidemiology MH - *Delphi Technique MH - *Mobile Applications MH - Female MH - Child, Preschool MH - Male MH - Infant MH - Adult PMC - PMC11668187 OTO - NOTNLM OT - mobile app OT - stunting OT - stunting prevention COIS- Conflicts of Interest: None declared. EDAT- 2024/12/17 12:31 MHDA- 2024/12/17 18:23 PMCR- 2024/12/17 CRDT- 2024/12/17 11:43 PHST- 2024/06/10 00:00 [received] PHST- 2024/09/05 00:00 [revised] PHST- 2024/10/14 00:00 [accepted] PHST- 2024/12/17 18:23 [medline] PHST- 2024/12/17 12:31 [pubmed] PHST- 2024/12/17 11:43 [entrez] PHST- 2024/12/17 00:00 [pmc-release] AID - v11i1e54862 [pii] AID - 54862 [pii] AID - 10.2196/54862 [doi] PST - epublish SO - JMIR Hum Factors. 2024 Dec 17;11:e54862. doi: 10.2196/54862. PMID- 39687499 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250104 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 6 DP - 2024 TI - Stress, physical activity, and mindfulness practices among youth amidst COVID-19. PG - 1493729 LID - 10.3389/fspor.2024.1493729 [doi] LID - 1493729 AB - INTRODUCTION: The COVID-19 pandemic has exacerbated stress and anxiety among young people, particularly university students, impacting their mental well-being and daily life. Given the rise in social isolation and economic uncertainty, the adoption of mindfulness practices such as sophrology, meditation, and yoga becomes essential for improving their mental health. This study aims to evaluate the impact of these practices on stress levels and their effect on engagement in physical activities among youths. METHOD: This study employed a mixed methods design to assess the impact of different wellness and mindfulness practices on stress levels and physical activity (PA) engagement among university students. Quantitative data were gathered electronically from 218 students at the University of Rouen and the university of Paris-Cite through validated questionnaires, including custom tools on sports and mindfulness practices and the Perceived Stress Scale (PSS). The sample consisted mainly of young adults aged 18 to 35, with a majority of 170 female and 48 male participants. Qualitative insights were gathered through semi-structured interviews with three directors of the university's sports and physical activities department (SUAPS), as well as four wellness program instructors. Data analysis involved statistical techniques using Statistical Analysis System (SAS) software for quantitative data, while qualitative data were analyzed thematically using Sphinx software, a tool for textual analysis. Ethical approval for the study was obtained, and confidentiality of all participants was maintained throughout the research. RESULTS AND CONCLUSION: The COVID-19 pandemic had significant effects on French university students' PA, mental health, and stress levels. Lockdowns led to a decline in sports practices for many, while others adapted by increasing their engagement in fitness and wellness practices. The majority of participants (64.68%) reported moderate levels of stress. A significant correlation was found between motivations for mental health support and stress management, and higher levels of stress (p = 0.0000 and p = 0.0024, respectively). Regular participation in wellness activities was associated with lower stress (p = 0.0193). The findings reinforce the idea that incorporating wellness practices into educational environments can strengthen students' mental resilience and overall well-being, equipping them with essential tools to effectively cope with future stressors. CI - (c) 2024 El Hajj, Noulhiane, Andrieu, Heutte and Sirost. FAU - El Hajj, A AU - El Hajj A AD - Sport Sciences Department, Univ Rouen Normandie, CETAPS, Rouen, France. FAU - Noulhiane, M AU - Noulhiane M AD - CEA-Neurospin, UNIACT - Universite Paris Saclay, Department of Neuroscience, Gif-sur-Yvette, France. AD - INSERM U1141, Universite Paris Cite, Paris, France. FAU - Andrieu, B AU - Andrieu B AD - Sport Sciences Department, Universite Paris Cite, I3SP, Paris, France. FAU - Heutte, Natcha AU - Heutte N AD - Sport Sciences Department, Univ Rouen Normandie, CETAPS, Rouen, France. FAU - Sirost, O AU - Sirost O AD - Sport Sciences Department, Univ Rouen Normandie, CETAPS, Rouen, France. LA - eng PT - Journal Article DEP - 20241202 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC11646766 OTO - NOTNLM OT - mental well-being OT - physical activity OT - stress OT - university students OT - wellness and mindfulness activities OT - youth COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/12/17 11:49 MHDA- 2024/12/17 11:50 PMCR- 2024/12/02 CRDT- 2024/12/17 04:45 PHST- 2024/09/09 00:00 [received] PHST- 2024/11/18 00:00 [accepted] PHST- 2024/12/17 11:50 [medline] PHST- 2024/12/17 11:49 [pubmed] PHST- 2024/12/17 04:45 [entrez] PHST- 2024/12/02 00:00 [pmc-release] AID - 10.3389/fspor.2024.1493729 [doi] PST - epublish SO - Front Sports Act Living. 2024 Dec 2;6:1493729. doi: 10.3389/fspor.2024.1493729. eCollection 2024. PMID- 39686996 OWN - NLM STAT- MEDLINE DCOM- 20241217 LR - 20260807 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 12 DP - 2024 TI - Adiposity and body fat distribution based on skinfold thicknesses and body circumferences in Czech preschool children, secular changes. PG - e18695 LID - 10.7717/peerj.18695 [doi] LID - e18695 AB - BACKGROUND: The long-standing widespread prevalence of obesity includes issues of its evaluation. Nutritional status may be assessed using various tools and methods; among others simple anthropometric measurements are well established. Widely used body mass index (BMI), presents an obstacle of needing to calculate a standard deviation score (SD) for correct use in the child population. As BMI overlooks body composition, it is necessary to evaluate fat and muscle mass with different methods. Established skinfolds and circumferences are used in many variations and equations to accomplish that goal; however, the parameters used in these methods also undergo secular changes. Furthermore, secular changes have been documented in fat mass distribution. The aim of the study is to assess secular changes of skinfolds thickness and body circumferences and evaluate their validity for use in clinical practice and population research. METHODS AND SAMPLE: Our database consisted of a recent (2016-2022) sample with 594 participants (298 males) and a reference sample (from 1990) with 2,910 participants (1,207 males). Both cohorts comprised Czech preschool children, aged 4.00 to 6.99 years. With standard methodology, anthropometric parameters were obtained for 13 skinfolds and eight circumferences, by trained staff. The equations of Slaughter, Durnin and Deurenberg were correspondingly calculated. Statistical evaluation was conducted in the R programming language, using Welch's test, Cohen's d and the Bland-Altman method. RESULTS: Our study found significant increases in skinfold thickness on the abdomen, chest I. and forearm, with high clinical relevance (p >/= 0.01; d = range from 0.20 to 0.70). Contrastingly, apart from the abdominal area, a decrease of circumferences was observed. The body fat percentage estimation equations were tested for bias in the recent sample in the context of bioimpedance analysis with the Bland-Altman method. All equations are suitable for application in clinical use. DISCUSSION: Documented secular changes in fat mass distribution are only part of a contemporary accelerating trend of obesity prevalence. Our findings support the trend of a decline of circumferences and rise of skinfold thickness in corresponding areas, especially on the limbs, that is evidenced by the trend of latent obesity. The results of the study show the need to complement established diagnostic procedures in childhood obesitology with abdominal and midthigh circumferences and optionally even the maximal circumference of the forearm. These circumferences should always be measured alongside the skinfold thickness of the region. Only in this way can the overall adiposity of an individual with regard to secular changes, including the detection of latent obesity, be objectively evaluated. CI - (c) 2024 Vazna et al. FAU - Vazna, Anna AU - Vazna A AUID- ORCID: 0009-0007-6546-0285 AD - Department of Anthropology and Human Genetics, Charles University, Prague, Czech Republic. FAU - Novak, Jan M AU - Novak JM AUID- ORCID: 0000-0001-5545-2723 AD - Department of Anthropology and Human Genetics, Charles University, Prague, Czech Republic. FAU - Danis, Robert AU - Danis R AD - Division of Child Health Promotion, Department of Hygiene, Third Faculty of Medicine, Charles University Prague, Prague, Czech Republic. FAU - Sedlak, Petr AU - Sedlak P AD - Department of Anthropology and Human Genetics, Charles University, Prague, Czech Republic. AD - Division of Child Health Promotion, Department of Hygiene, Third Faculty of Medicine, Charles University Prague, Prague, Czech Republic. LA - eng PT - Journal Article DEP - 20241213 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - Male MH - *Skinfold Thickness MH - Female MH - Czech Republic/epidemiology MH - Child, Preschool MH - *Adiposity MH - Child MH - *Body Fat Distribution MH - Body Mass Index MH - Anthropometry/methods MH - Body Composition/physiology MH - Pediatric Obesity/epidemiology/diagnosis PMC - PMC11648688 OTO - NOTNLM OT - Body circumferences OT - Fat mass distribution OT - Obesity OT - Preschool children OT - Secular changes OT - Skinfold thickness COIS- The authors declare that they have no competing interests. EDAT- 2024/12/17 11:50 MHDA- 2024/12/17 12:31 PMCR- 2024/12/13 CRDT- 2024/12/17 04:35 PHST- 2024/09/17 00:00 [received] PHST- 2024/11/21 00:00 [accepted] PHST- 2024/12/17 12:31 [medline] PHST- 2024/12/17 11:50 [pubmed] PHST- 2024/12/17 04:35 [entrez] PHST- 2024/12/13 00:00 [pmc-release] AID - 18695 [pii] AID - 10.7717/peerj.18695 [doi] PST - epublish SO - PeerJ. 2024 Dec 13;12:e18695. doi: 10.7717/peerj.18695. eCollection 2024. PMID- 39686752 OWN - NLM STAT- MEDLINE DCOM- 20250427 LR - 20260818 IS - 1557-8593 (Electronic) IS - 1520-9156 (Print) IS - 1520-9156 (Linking) VI - 27 IP - 4 DP - 2025 Apr TI - Enhancing Type 1 Diabetes Immunological Risk Prediction with Continuous Glucose Monitoring and Genetic Profiling. PG - 292-300 LID - 10.1089/dia.2024.0496 [doi] AB - Background: Early identification of individuals at high risk for type 1 diabetes (T1D) is essential for timely intervention. Islet autoantibodies (AB) and continuous glucose monitoring (CGM) reveal early signs of glycemic dysregulation, while T1D genetic risk scores (GRS) further improve disease prediction. We use CGM data and T1D GRS to develop an AB classifier (1 AB vs. >/=2 AB) and predict early T1D risk. Methods: Thirty-nine AB-positive (18 with 1 and 21 with >/=2 AB) healthy relatives of T1D (mean age 22.1 +/- 11.1 years, HbA1c 5.3 +/- 0.3%, body mass index 24.1 +/- 5.8 kg/m(2)) were enrolled in a National Institutes of Health's (NIH) TrialNet ancillary study. Participants wore CGMs for a week and consumed three standardized liquid mixed meals (SLMM). Post-SLMM CGM glycemic features and T1D GRS were used in a linear support vector machine (SVM) model with recursive feature elimination (RFE) for AB classification, evaluated via fivefold cross-validation using the receiver operating characteristic and precision-recall area under the curve (AUC-ROC/PR). Results: Significant differences between the AB groups were observed in the post-SLMM percent time of glucose >180 mg/dL and GRS (P = 0.020 and P = 0.001, respectively). An SVM model with two RFE-selected features (T1D GRS and incremental AUC) achieved the best performance, classifying 1 versus >/=2 AB individuals with an AUC-ROC of 0.93 (95% confidence interval [CI]: 0.83-1.00) and AUC-PR of 0.89 (95% CI: 0.71-0.99), compared with AUC-ROC of 0.80 (95% CI: 0.46-1.00) and AUC-PR of 0.82 (95% CI: 0.71-0.93) using all features. Conclusions: A machine learning approach combining a 1-week CGM home test and T1D GRS reliably assesses T1D immunological risk, enabling early intervention. FAU - Montaser, Eslam AU - Montaser E AUID- ORCID: 0000-0002-3138-1964 AD - Division of Endocrinology and Metabolism, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA. FAU - Farhy, Leon S AU - Farhy LS AD - Center for Diabetes Technology, School of Medicine, University of Virginia, Charlottesville, Virginia, USA. AD - Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine, University of Virginia, Charlottesville, Virginia, USA. FAU - Rich, Stephen S AU - Rich SS AD - Department of Genome Sciences, School of Medicine, University of Virginia, Charlottesville, Virginia, USA. LA - eng SI - ClinicalTrials.gov/NCT 02663661 GR - U01 DK107014/DK/NIDDK NIH HHS/United States GR - U01 DK085466/DK/NIDDK NIH HHS/United States GR - DP3 DK106907/DK/NIDDK NIH HHS/United States GR - U01 DK103282/DK/NIDDK NIH HHS/United States GR - U01 DK061058/DK/NIDDK NIH HHS/United States GR - U01 DK103266/DK/NIDDK NIH HHS/United States GR - U01 DK107013/DK/NIDDK NIH HHS/United States GR - U01 DK103180/DK/NIDDK NIH HHS/United States GR - U01 DK061042/DK/NIDDK NIH HHS/United States GR - U01 DK106984/DK/NIDDK NIH HHS/United States GR - U01 DK085453/DK/NIDDK NIH HHS/United States GR - U01 DK085499/DK/NIDDK NIH HHS/United States GR - U01 DK085465/DK/NIDDK NIH HHS/United States GR - U01 DK106994/DK/NIDDK NIH HHS/United States GR - U01 DK085476/DK/NIDDK NIH HHS/United States GR - U01 DK061010/DK/NIDDK NIH HHS/United States GR - U01 DK103153/DK/NIDDK NIH HHS/United States GR - U01 DK085504/DK/NIDDK NIH HHS/United States GR - U01 DK061034/DK/NIDDK NIH HHS/United States GR - U01 DK106993/DK/NIDDK NIH HHS/United States GR - U01 DK085461/DK/NIDDK NIH HHS/United States GR - U01 DK085509/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20241217 PL - United States TA - Diabetes Technol Ther JT - Diabetes technology & therapeutics JID - 100889084 RN - 0 (Blood Glucose) RN - 0 (Autoantibodies) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/genetics/immunology/blood/diagnosis MH - Female MH - Male MH - *Blood Glucose Self-Monitoring MH - Young Adult MH - *Blood Glucose/analysis MH - Adult MH - *Autoantibodies/blood MH - Adolescent MH - Risk Assessment MH - Genetic Predisposition to Disease MH - Support Vector Machine MH - Child MH - Continuous Glucose Monitoring PMC - PMC13354271 OTO - NOTNLM OT - continuous glucose monitoring OT - immunological risk OT - islet autoantibodies OT - machine learning OT - type 1 diabetes EDAT- 2024/12/17 11:50 MHDA- 2025/04/04 00:25 PMCR- 2026/04/01 CRDT- 2024/12/17 03:23 PHST- 2025/04/04 00:25 [medline] PHST- 2024/12/17 11:50 [pubmed] PHST- 2024/12/17 03:23 [entrez] PHST- 2026/04/01 00:00 [pmc-release] AID - 10.1089_dia.2024.0496 [pii] AID - 10.1089/dia.2024.0496 [doi] PST - ppublish SO - Diabetes Technol Ther. 2025 Apr;27(4):292-300. doi: 10.1089/dia.2024.0496. Epub 2024 Dec 17. PMID- 39685919 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260913 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 13 IP - 23 DP - 2024 Dec 7 TI - Analysing Digital Engagement Patterns: A Machine Learning Investigation into Social Anxiety Among Adolescents with ADHD. LID - 10.3390/jcm13237461 [doi] LID - 7461 AB - Background: The relationship between screen time and mental health among adolescents, particularly those identified as "digital natives", has become increasingly pertinent, especially in the context of heightened digital engagement during the COVID-19 pandemic. This study aims to examine the associations between digital engagement patterns, ADHD severity, and anxiety symptoms in adolescents aged 11-18. Methods: A cross-sectional observational study was conducted with a sample of 97 adolescents diagnosed with ADHD. Participants completed validated questionnaires assessing daily digital activities and anxiety symptoms while caregivers provided additional contextual information. Data were analyzed using Random Forest regression to identify relationships between screen time, ADHD severity, and anxiety symptoms. Results: The findings indicate an average screen time of 6.6 h on weekdays and 8.1 h on weekends, with social media emerging as the primary activity, particularly among female participants. Notable gender differences were identified, with family dynamics influencing digital engagement; family disputes had a more significant impact on girls than boys. Furthermore, specific anxiety traits, i.e., physical symptoms and harm avoidance, significantly predicted time spent on social media across all genders considered in the study, while others, namely social anxiety and separation anxiety, were less valuable. Conclusions: This study highlights the complex interplay between screen time, ADHD, and anxiety symptoms in adolescents. These findings underscore the importance of tailored interventions that address the nuanced relationships between digital engagement and mental health in this population, warranting further research to develop effective management strategies. FAU - Sipos, Roxana AU - Sipos R AUID- ORCID: 0000-0001-5017-6387 AD - Department of Neuroscience, Psychiatry and Pediatric Psychiatry, "Iuliu Hatieganu" University of Medicine and Pharmacy, 57 Republicii Street, 400489 Cluj-Napoca, Romania. FAU - Vaidean, Tudor AU - Vaidean T AUID- ORCID: 0009-0001-0853-3683 AD - Department of Neuroscience, Psychiatry and Pediatric Psychiatry, "Iuliu Hatieganu" University of Medicine and Pharmacy, 57 Republicii Street, 400489 Cluj-Napoca, Romania. AD - Department of Clinical Psychology and Psychotherapy, Faculty of Psychology and Educational Sciences, Babes-Bolyai University, 37 Republicii Street, 400015 Cluj-Napoca, Romania. FAU - Rapciuc, Andreea-Marlena AU - Rapciuc AM AUID- ORCID: 0009-0008-8376-1636 AD - Clinical Department of Nephrology, County Emergency Clinical Hospital Cluj, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania. FAU - Poetar, Costina-Ruxandra AU - Poetar CR AD - Department of Clinical Psychology and Psychotherapy, Faculty of Psychology and Educational Sciences, Babes-Bolyai University, 37 Republicii Street, 400015 Cluj-Napoca, Romania. FAU - Predescu, Elena AU - Predescu E AUID- ORCID: 0000-0001-5682-1850 AD - Department of Neuroscience, Psychiatry and Pediatric Psychiatry, "Iuliu Hatieganu" University of Medicine and Pharmacy, 57 Republicii Street, 400489 Cluj-Napoca, Romania. LA - eng PT - Journal Article DEP - 20241207 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC11642364 OTO - NOTNLM OT - ADHD OT - adolescents OT - anxiety symptoms OT - digital engagement OT - screen time COIS- The authors declare no conflicts of interest. EDAT- 2024/12/17 11:49 MHDA- 2024/12/17 11:50 PMCR- 2024/12/07 CRDT- 2024/12/17 01:21 PHST- 2024/11/17 00:00 [received] PHST- 2024/11/28 00:00 [revised] PHST- 2024/12/05 00:00 [accepted] PHST- 2024/12/17 11:50 [medline] PHST- 2024/12/17 11:49 [pubmed] PHST- 2024/12/17 01:21 [entrez] PHST- 2024/12/07 00:00 [pmc-release] AID - jcm13237461 [pii] AID - jcm-13-07461 [pii] AID - 10.3390/jcm13237461 [doi] PST - epublish SO - J Clin Med. 2024 Dec 7;13(23):7461. doi: 10.3390/jcm13237461. PMID- 39683453 OWN - NLM STAT- MEDLINE DCOM- 20241217 LR - 20260127 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 23 DP - 2024 Nov 26 TI - Energy, Macronutrients and Micronutrients Intake Among Pregnant Women in Lebanon: Findings from the Updated Lebanese National Food Consumption Survey (LEBANON-FCS). LID - 10.3390/nu16234059 [doi] LID - 4059 AB - BACKGROUND: Pregnancy is a crucial period for maternal and fetal health, and in Lebanon, where cultural and economic factors influence dietary practices, there is an urgent need to evaluate the food consumption patterns and diet quality of pregnant women. AIM: To evaluate the food consumption patterns, energy intake, as well as macro- and micro-nutrient intake among a nationally representative sample of Lebanese pregnant women aged 18-49 years old. METHODS: A cross-sectional study was carried out from March to October 2023, involving 500 pregnant women from all eight Lebanese governorates. Sociodemographic and medical information was gathered, food consumption was evaluated using a validated Food Frequency Questionnaire (FFQ) and three 24-h recall, and anthropometric measurements were recorded. RESULTS: The current population did not meet the USDA healthy pattern recommendations for whole grain, seafood, dairy, nuts, seeds and soy products consumption but exceeded the guidelines for vegetables, meats, poultry, eggs, oils, and refined grains. According to Mediterranean diet guidelines, the sample fell short in recommended intakes for fruits, olives/nuts/seeds, eggs, and olive oil, while surpassing the recommended levels for potatoes, legumes, pulses, sweets, red meat, processed meat, and fish and seafood. None of the participants met the energy requirements for their trimester and age group. In terms of macronutrient intake, the requirements for protein, unsaturated fats, and fiber were not met, while intakes of fats and sugars were exceeded. Regarding micronutrients, the recommended levels were not fully achieved, with particularly low intakes of vitamin D and iodine, as well as inadequate adherence to recommendations for iron, calcium, vitamin A, vitamin E, zinc, and choline. Additionally, a third of the participants did not meet the recommended intakes for folate and vitamin B12. CONCLUSIONS: The findings reveal significant dietary inadequacies among the current population, with participants failing to meet essential recommendations for whole grains and key food groups, alongside insufficient energy intake for their trimesters and age groups. Critical micronutrient deficiencies, particularly in vitamin D, iodine, and B vitamins, highlight the urgent need for targeted nutritional interventions and public health initiatives to improve dietary practices among pregnant women in Lebanon. FAU - Mahfouz, Rana AU - Mahfouz R AUID- ORCID: 0000-0002-5101-837X AD - Department of Nutrition and Food Sciences, Faculty of Arts and Sciences, Holy Spirit University of Kaslik (USEK), Jounieh P.O. Box 446, Lebanon. FAU - Akiki, Marie-Therese AU - Akiki MT AD - Department of Nutrition and Food Sciences, Faculty of Arts and Sciences, Holy Spirit University of Kaslik (USEK), Jounieh P.O. Box 446, Lebanon. FAU - Ndayra, Vanessa AU - Ndayra V AD - Department of Nutrition and Food Sciences, Faculty of Arts and Sciences, Holy Spirit University of Kaslik (USEK), Jounieh P.O. Box 446, Lebanon. FAU - El Khoury, Rebecca AU - El Khoury R AD - Department of Nutrition and Food Sciences, Faculty of Arts and Sciences, Holy Spirit University of Kaslik (USEK), Jounieh P.O. Box 446, Lebanon. FAU - Chawi, Marise AU - Chawi M AD - Department of Nutrition and Food Sciences, Faculty of Arts and Sciences, Holy Spirit University of Kaslik (USEK), Jounieh P.O. Box 446, Lebanon. FAU - Hatem, Majida AU - Hatem M AD - Department of Nutrition and Food Sciences, Faculty of Arts and Sciences, Holy Spirit University of Kaslik (USEK), Jounieh P.O. Box 446, Lebanon. FAU - Hanna-Wakim, Lara AU - Hanna-Wakim L AUID- ORCID: 0000-0002-2948-8148 AD - Department of Agricultural and Food Engineering, School of Engineering, Holy Spirit University of Kaslik (USEK), Jounieh P.O. Box 446, Lebanon. FAU - Sacre, Yonna AU - Sacre Y AD - Department of Nutrition and Food Sciences, Faculty of Arts and Sciences, Holy Spirit University of Kaslik (USEK), Jounieh P.O. Box 446, Lebanon. FAU - Hoteit, Maha AU - Hoteit M AUID- ORCID: 0000-0001-7392-4835 AD - Food Sciences Unit, National Council for Scientific Research of Lebanon (CNRS-L), Beirut P.O. Box 11-8281, Lebanon. AD - PHENOL Research Program, Faculty of Public Health, Section 1, Lebanese University, Beirut P.O. Box 6573, Lebanon. LA - eng PT - Journal Article DEP - 20241126 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Micronutrients) RN - 0 (Nutrients) SB - IM MH - Humans MH - Female MH - Lebanon MH - Adult MH - Pregnancy MH - Young Adult MH - *Energy Intake MH - Cross-Sectional Studies MH - Adolescent MH - Middle Aged MH - *Micronutrients/administration & dosage MH - *Nutrients/administration & dosage/analysis MH - Diet/statistics & numerical data MH - Diet Surveys MH - Feeding Behavior MH - Nutrition Surveys MH - Nutritional Status MH - Pregnant People PMC - PMC11643267 OTO - NOTNLM OT - Lebanon OT - Mediterranean diet OT - USDA guidelines OT - food consumption OT - food groups OT - macronutrients OT - micronutrients OT - pregnant women COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/12/17 11:49 MHDA- 2024/12/17 11:50 PMCR- 2024/11/26 CRDT- 2024/12/17 01:07 PHST- 2024/10/24 00:00 [received] PHST- 2024/11/18 00:00 [revised] PHST- 2024/11/22 00:00 [accepted] PHST- 2024/12/17 11:50 [medline] PHST- 2024/12/17 11:49 [pubmed] PHST- 2024/12/17 01:07 [entrez] PHST- 2024/11/26 00:00 [pmc-release] AID - nu16234059 [pii] AID - nutrients-16-04059 [pii] AID - 10.3390/nu16234059 [doi] PST - epublish SO - Nutrients. 2024 Nov 26;16(23):4059. doi: 10.3390/nu16234059. PMID- 39683374 OWN - NLM STAT- MEDLINE DCOM- 20241217 LR - 20250104 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 23 DP - 2024 Nov 21 TI - Exploring the Relationship Between Cooking and Food Skills and Eating Competence Among Brazilian Adults. LID - 10.3390/nu16233980 [doi] LID - 3980 AB - BACKGROUND: Cooking skills (CSs) and food skills (FSs) are essential in promoting healthier eating habits. Eating competence (EC) encompasses an individual's self-regulation, enjoyment, and positive attitude toward food, contributing to their overall well-being. However, no research has explored the relationship between CSs, FSs, and EC, particularly within the Brazilian context. OBJECTIVE: This study aimed to assess the association between EC and CFSs among Brazilian adults. METHODS: A cross-sectional survey was conducted among 1266 Brazilian adults using two validated instruments: the Cooking and Food Skill Confidence Questionnaire (CFS) and the Brazilian version of the Satter Eating Competence Inventory (ecSI2.0BR). Pearson's and Spearman's correlations were used to analyze the relationships between CSs, FSs, and EC. RESULTS: A significant positive correlation was found between higher levels of CSs and the overall EC (r = 0.417, p < 0.001), with complex cooking tasks showing stronger associations with EC. Contextual skills within EC exhibited the highest correlation with FSs (r = 0.487). Basic tasks, such as microwaving food, showed weaker associations with EC. CONCLUSIONS: The findings suggest that enhancing cooking and food skills may support greater eating competence, promoting healthier eating behaviors. Public health programs should consider integrating cooking skill development to foster better dietary outcomes and improve individual well-being. FAU - Lins, Maisa AU - Lins M AUID- ORCID: 0000-0001-8225-0537 AD - Department of Nutrition, Faculty of Health Sciences, Campus Universitario Darcy Ribeiro, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Nakano, Eduardo Yoshio AU - Nakano EY AUID- ORCID: 0000-0002-9071-8512 AD - Department of Statistics, Campus Universitario Darcy Ribeiro, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Soares, Joao Rafael Queiroz AU - Soares JRQ AUID- ORCID: 0000-0002-6702-677X AD - Department of Medicine, Faculty of Education and Health Sciences, Campus Asa Norte, Centro Universitario de Brasilia (CEUB), Brasilia 70790-075, Brazil. FAU - Queiroz, Fabiana Lopes Nalon de AU - Queiroz FLN AD - Department of Nutrition, Faculty of Health Sciences, Campus Universitario Darcy Ribeiro, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Botelho, Raquel Braz Assuncao AU - Botelho RBA AUID- ORCID: 0000-0002-0369-287X AD - Department of Nutrition, Faculty of Health Sciences, Campus Universitario Darcy Ribeiro, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Raposo, Antonio AU - Raposo A AUID- ORCID: 0000-0002-5286-2249 AD - CBIOS (Research Center for Biosciences and Health Technologies), Universidade Lusofona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisboa, Portugal. FAU - Zandonadi, Renata Puppin AU - Zandonadi RP AUID- ORCID: 0000-0003-0370-3089 AD - Department of Nutrition, Faculty of Health Sciences, Campus Universitario Darcy Ribeiro, University of Brasilia, Brasilia 70910-900, Brazil. LA - eng GR - Fundacao de Apoio a Pesquisa do Distrito Federal/Fundacao de Apoio a Pesquisa do Distrito Federal/ PT - Journal Article DEP - 20241121 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Cooking MH - Brazil MH - Male MH - Adult MH - Female MH - Cross-Sectional Studies MH - *Feeding Behavior/psychology MH - Middle Aged MH - Surveys and Questionnaires MH - Young Adult MH - Diet, Healthy/psychology MH - Eating/psychology MH - Adolescent MH - Aged PMC - PMC11643768 OTO - NOTNLM OT - Brazilian adults OT - cooking skills OT - eating competence OT - food preparation OT - health OT - nutrition COIS- The authors declare no conflicts of interest. EDAT- 2024/12/17 11:49 MHDA- 2024/12/17 11:50 PMCR- 2024/11/21 CRDT- 2024/12/17 01:07 PHST- 2024/11/04 00:00 [received] PHST- 2024/11/14 00:00 [revised] PHST- 2024/11/19 00:00 [accepted] PHST- 2024/12/17 11:50 [medline] PHST- 2024/12/17 11:49 [pubmed] PHST- 2024/12/17 01:07 [entrez] PHST- 2024/11/21 00:00 [pmc-release] AID - nu16233980 [pii] AID - nutrients-16-03980 [pii] AID - 10.3390/nu16233980 [doi] PST - epublish SO - Nutrients. 2024 Nov 21;16(23):3980. doi: 10.3390/nu16233980. PMID- 39682566 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250104 IS - 2075-4418 (Print) IS - 2075-4418 (Electronic) IS - 2075-4418 (Linking) VI - 14 IP - 23 DP - 2024 Nov 25 TI - Design and Development of Portable Body Composition Analyzer for Children. LID - 10.3390/diagnostics14232658 [doi] LID - 2658 AB - OBJECTIVES: The aim of this study was (i) to design and develop a portable BCA device for measuring body composition parameters such as body weight, body fat (BF) %, total body water (TBW), fat-free mass (FFM), muscle mass (MM), and bone mass (BM); (ii) to validate the developed portable BCA with the Tanita MC 980 MA BCA device. METHODS: For this current study, two hundred healthy and obese subjects, whose ages ranged from 8 to 12 years (8.4 +/- 1.7), were considered. RESULTS: The highest percentage difference between the two study groups was found to be in BFat (50.39%), followed by body mass index (BMI) (41.73 kg), FFM (38.32 kg), and MM (37.89 kg), and this was found to be statistically significant. The results obtained from the designed prototype of the body composition analyzer were validated using Tanita MC 980MA BCA. The overall error% was calculated as +/-3% for measuring the different body composition parameters. CONCLUSIONS: Due to its low standard error and high overall accuracy, the BCA prototype demonstrates the potential to be a dependable instrument for evaluating and tracking the body composition of children. FAU - Rashmi, Richa AU - Rashmi R AD - Department of Biomedical Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Chennai 603203, India. AD - Department of Quality Assurance Cell, ANIIMS, GB Pant Hospital, Sri Vijaya Puram 744103, India. FAU - Umapathy, Snekhalatha AU - Umapathy S AD - Department of Biomedical Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Chennai 603203, India. FAU - Alhajlah, Omar AU - Alhajlah O AD - Department of Applied Computer Sciences, Applied Computer Science College, King Saud University, Riyadh 11451, Saudi Arabia. FAU - Almutairi, Fadiyah AU - Almutairi F AD - Department of Information System, College of Computer and Information Sciences (CCIS), Majmaah University, Al Majmaah 11952, Saudi Arabia. FAU - Aslam, Shabnam Mohamed AU - Aslam SM AUID- ORCID: 0000-0001-9015-7551 AD - Department of Information Technology, College of Computer and Information Sciences (CCIS), Majmaah University, Al Majmaah 11952, Saudi Arabia. LA - eng PT - Journal Article DEP - 20241125 PL - Switzerland TA - Diagnostics (Basel) JT - Diagnostics (Basel, Switzerland) JID - 101658402 PMC - PMC11639819 OTO - NOTNLM OT - bioelectrical impedance analysis OT - body composition analyzer OT - body mass index OT - childhood obesity OT - fat free mass COIS- The authors declare no conflicts of interest. EDAT- 2024/12/17 11:48 MHDA- 2024/12/17 11:49 PMCR- 2024/11/25 CRDT- 2024/12/17 01:03 PHST- 2024/10/11 00:00 [received] PHST- 2024/11/11 00:00 [revised] PHST- 2024/11/20 00:00 [accepted] PHST- 2024/12/17 11:49 [medline] PHST- 2024/12/17 11:48 [pubmed] PHST- 2024/12/17 01:03 [entrez] PHST- 2024/11/25 00:00 [pmc-release] AID - diagnostics14232658 [pii] AID - diagnostics-14-02658 [pii] AID - 10.3390/diagnostics14232658 [doi] PST - epublish SO - Diagnostics (Basel). 2024 Nov 25;14(23):2658. doi: 10.3390/diagnostics14232658. PMID- 39682027 OWN - NLM STAT- MEDLINE DCOM- 20260116 LR - 20260709 IS - 2473-4446 (Electronic) IS - 2473-3938 (Linking) VI - 10 IP - 1 DP - 2026 Feb TI - Assessing maximal sprinting speed in soccer - criterion validity of commonly used devices. PG - 126-131 LID - 10.1080/24733938.2024.2441321 [doi] AB - This study aimed to investigate the criterion validity of commonly used devices to assess maximal sprinting speed (MSS) in soccer. Thirty elite youth soccer players completed three trials of a 30-m sprint test to assess MSS. All sprints were simultaneously captured via a radar gun (Stalker ATS II), timing gates (Smartspeed Pro, Fusion Sport), a magnetic timing system (Humotion SmarTracks) and a global navigation satellite system (GNSS) (Kinexon Perform GPS Pro). The radar gun and the GNSS recorded sprinting speed continuously, while the fastest 5-m split during the 30-m sprint was used for the timing gates and the magnetic system. The best trial of the radar gun (i.e. criterion measure) and corresponding values of the other devices were analyzed. Equivalence testing was performed to assess the statistical equivalence of MSS between the radar gun and the three other devices against a difference value of +/- 0.36 km/h and Bland & Altman's 95% limits of agreement (LoA) were computed to investigate the agreement between MSS results. Differences between GNSS versus radar gun suggested a lack of systematic bias (-0.01 km/h, 95% confidence interval [CI] -0.15 to 0.15 km/h), whereas timing gates-based MSS assessments were prone to larger uncertainty compared to the criterion method (-0.19 km/h, 95% CI: -0.37 to 0.00 km/h) given the pre-defined region of equivalence. The magnetic system (-0.54 km/h; -0.71 to -0.37 km/h) overestimated MSS compared to the radar gun with mean differences being non-equivalent. Based on the practically important difference bounds of +/- 0.36 km/h, the width of the 95% LoA was broad enough to suggest a lack of reasonable agreement for MSS assessment regardless of device of interest (GNSS: -0.79 to 0.78 km/h, timing gates: -0.79 to 1.16 km/h, magnetic system: -0.24 to 1.32 km/h). While our results suggested a lack of systematic bias for the investigated GNSS and the timing gates when compared against the radar gun for MSS assessment over 30 m in elite youth soccer players on a team level, the width of the 95% LoAs did not indicate reasonable measurement interchangeability on an individual level. Based on the present results, we do not recommend using the magnetic system for both group and individual analyses in this population. FAU - Altmann, Stefan AU - Altmann S AD - TSG ResearchLab gGmbH, Zuzenhausen, Germany. AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Ruf, Ludwig AU - Ruf L AD - TSG ResearchLab gGmbH, Zuzenhausen, Germany. AD - TSG 1899 Hoffenheim, Zuzenhausen, Germany. FAU - Backfisch, Marco AU - Backfisch M AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. AD - TSG 1899 Hoffenheim, Zuzenhausen, Germany. FAU - Thron, Maximiliane AU - Thron M AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Woll, Alexander AU - Woll A AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Walter, Linus AU - Walter L AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Kaul, Damon AU - Kaul D AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Bergdolt, Luca AU - Bergdolt L AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Hartel, Sascha AU - Hartel S AD - TSG 1899 Hoffenheim, Zuzenhausen, Germany. LA - eng PT - Journal Article PT - Validation Study DEP - 20241216 PL - England TA - Sci Med Footb JT - Science & medicine in football JID - 101724288 SB - IM MH - Humans MH - *Soccer/physiology MH - *Running/physiology MH - *Athletic Performance/physiology MH - Adolescent MH - Geographic Information Systems MH - Male MH - Reproducibility of Results MH - Radar OTO - NOTNLM OT - Football OT - acceleration OT - performance OT - speed OT - team sports EDAT- 2024/12/17 11:49 MHDA- 2026/01/16 15:04 CRDT- 2024/12/17 00:13 PHST- 2026/01/16 15:04 [medline] PHST- 2024/12/17 11:49 [pubmed] PHST- 2024/12/17 00:13 [entrez] AID - 10.1080/24733938.2024.2441321 [doi] PST - ppublish SO - Sci Med Footb. 2026 Feb;10(1):126-131. doi: 10.1080/24733938.2024.2441321. Epub 2024 Dec 16. PMID- 39681546 OWN - NLM STAT- MEDLINE DCOM- 20250504 LR - 20250504 IS - 1941-2452 (Electronic) IS - 0884-5336 (Linking) VI - 40 IP - 3 DP - 2025 Jun TI - Validity of a nutrition screening tool for childhood cancer. PG - 690-698 LID - 10.1002/ncp.11265 [doi] AB - BACKGROUND: Malnutrition in pediatric oncology patients is a serious clinical condition. There is a need for standardized nutrition screening in pediatric oncology patients, as nutrition screening can offer a simple method to identify children with cancer at risk of malnutrition. This study aimed to determine the validity of a Turkish version of nutrition screening tool for childhood cancer (SCAN) in identifying the risk of malnutrition among children with cancer. MATERIALS AND METHODS: A cross-sectional study was conducted with 78 children with cancer admitted to the pediatric hematology-oncology unit of a university hospital. In the first stage of this study, SCAN was translated into Turkish, and in the second stage, the validity of SCAN against pediatric Subjective Global Nutritional Assessment (SGNA) and Academy of Nutrition and Dietetics/American Society for Parenteral and Enteral Nutrition (AND/ASPEN) malnutrition criteria were evaluated. RESULTS: Patients had a median age of 8.0 years (range, 2-18 years; IQR, 5-14 years), 61.5% were male, and 60.3% were diagnosed with leukemia. According to SCAN, 53.8% had high risk of malnutrition. Validation of SCAN against pediatric SGNA showed that SCAN has a sensitivity of 97.5%, specificity of 94.5%, and accuracy of 96.1%. CONCLUSION: The risk of malnutrition is common in children with cancer. The Turkish version of the SCAN is a simple, quick, and valid tool to determine the risk of malnutrition in children with cancer. Further research is needed to understand the impact of nutrition interventions on clinical outcomes in children at risk for malnutrition based on SCAN. CI - (c) 2024 American Society for Parenteral and Enteral Nutrition. FAU - Kangalgil, Melda AU - Kangalgil M AUID- ORCID: 0000-0003-2868-8903 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Sivas Cumhuriyet University, Sivas, Turkey. FAU - Meral, Buket AU - Meral B AD - Department of Child Health and Diseases Nursing, Faculty of Health Sciences, Karadeniz Technical University, Trabzon, Turkey. FAU - Murphy Alford, Alexia J AU - Murphy Alford AJ AD - Nutritional and Health-Related Environmental Studies Section, Division of Human Health, International Atomic Energy Agency, Vienna, Austria. FAU - Erduran, Erol AU - Erduran E AD - Department of Pediatric Hematology and Oncology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey. LA - eng PT - Journal Article PT - Validation Study DEP - 20241216 PL - United States TA - Nutr Clin Pract JT - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JID - 8606733 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - Cross-Sectional Studies MH - Child, Preschool MH - *Neoplasms/complications MH - *Nutrition Assessment MH - Adolescent MH - Turkey MH - *Malnutrition/diagnosis/etiology MH - Reproducibility of Results MH - Nutritional Status MH - Sensitivity and Specificity MH - *Mass Screening/methods MH - *Child Nutrition Disorders/diagnosis/etiology OTO - NOTNLM OT - malnutrition OT - nutrition assessment OT - pediatric oncology EDAT- 2024/12/17 05:31 MHDA- 2025/05/04 15:35 CRDT- 2024/12/16 23:03 PHST- 2024/10/11 00:00 [revised] PHST- 2024/04/13 00:00 [received] PHST- 2024/11/26 00:00 [accepted] PHST- 2025/05/04 15:35 [medline] PHST- 2024/12/17 05:31 [pubmed] PHST- 2024/12/16 23:03 [entrez] AID - 10.1002/ncp.11265 [doi] PST - ppublish SO - Nutr Clin Pract. 2025 Jun;40(3):690-698. doi: 10.1002/ncp.11265. Epub 2024 Dec 16. PMID- 39680427 OWN - NLM STAT- MEDLINE DCOM- 20241216 LR - 20260703 IS - 2369-2960 (Electronic) IS - 2369-2960 (Linking) VI - 10 DP - 2024 Dec 16 TI - Using Video Cameras to Assess Physical Activity and Other Well-Being Behaviors in Urban Environments: Feasibility, Reliability, and Participant Reactivity Studies. PG - e66049 LID - 10.2196/66049 [doi] LID - e66049 AB - BACKGROUND: Unobtrusive observation is a promising method for assessing physical activity and other well-being behaviors (eg, social interactions) in urban environments, without participant burden and biases associated with self-report. However, current methods require multiple in-person observers. Using video cameras instead could allow for more accurate observations at lower cost and with greater flexibility in scheduling. OBJECTIVE: This research aimed to test the feasibility of using stationary wireless video cameras to observe physical activity and other well-being behaviors, and to assess its reliability and potential participant reactivity. METHODS: Across 3 cross-sectional studies, 148 hours of video recordings were collected from 6 outdoor public spaces in Manchester, United Kingdom. The videos were coded by 3 researchers using MOHAWk (Method for Observing Physical Activity and Wellbeing)-a validated in-person observation tool for assessing physical activity, social interactions, and people taking notice of the environment. Inter- and intrarater reliabilities were assessed using intraclass correlation coefficients (ICCs). Intercept surveys were conducted to assess public awareness of the cameras and whether they altered their behavior due to the presence of cameras. RESULTS: The 148 hours of video recordings were coded in 85 hours. Interrater reliability between independent coders was mostly "excellent" (ICCs>0.90; n=36), with a small number of "good" (ICCs>0.75; n=2), "moderate" (ICCs=0.5-0.75; n=3), or "poor" (ICCs<0.5; n=1) ICC values. Reliability decreased at night, particularly for coding ethnic group and social interactions, but remained mostly "excellent" or "good." Intrarater reliability within a single coder after a 2-week interval was "excellent" for all but 1 code, with 1 "good" ICC value for assessing vigorous physical activity, indicating that the coder could reproduce similar results over time. Intrarater reliability was generally similar during the day and night, apart from ICC values for coding ethnic group, which reduced from "excellent" to "good" at night. Intercept surveys with 86 public space users found that only 5 (5.8%) participants noticed the cameras used for this study. Importantly, all 5 said that they did not alter their behavior as a result of noticing these cameras, therefore, indicating no evidence of reactivity. CONCLUSIONS: Camera-based observation methods are more reliable than in-person observations and do not produce participant reactivity often associated with self-report methods. This method requires less time for data collection and coding, while allowing for safe nighttime observation without the risk to research staff. This research is a significant first step in demonstrating the potential for camera-based methods to improve natural experimental studies of real-world environmental interventions. It also provides a rigorous foundation for developing more scalable automated computer vision algorithms for assessing human behaviors. CI - (c)Jack S Benton, James Evans, Jamie Anderson, David P French. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org), 16.12.2024. FAU - Benton, Jack S AU - Benton JS AUID- ORCID: 0000-0002-7129-550X AD - Manchester Centre for Health Psychology, Division of Psychology and Mental Health, The University of Manchester, Manchester, United Kingdom. FAU - Evans, James AU - Evans J AUID- ORCID: 0000-0002-2953-1118 AD - Manchester Urban Institute, Department of Geography, The University of Manchester, Manchester, United Kingdom. FAU - Anderson, Jamie AU - Anderson J AUID- ORCID: 0000-0001-7378-7033 AD - Manchester Urban Institute, Department of Geography, The University of Manchester, Manchester, United Kingdom. FAU - French, David P AU - French DP AUID- ORCID: 0000-0002-7663-7804 AD - Manchester Centre for Health Psychology, Division of Psychology and Mental Health, The University of Manchester, Manchester, United Kingdom. LA - eng GR - WT_/Wellcome Trust/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241216 PL - Canada TA - JMIR Public Health Surveill JT - JMIR public health and surveillance JID - 101669345 SB - IM MH - Humans MH - Male MH - Female MH - Reproducibility of Results MH - *Feasibility Studies MH - *Video Recording MH - Adult MH - *Exercise/psychology MH - Cross-Sectional Studies MH - Middle Aged MH - United Kingdom MH - Urban Population/statistics & numerical data MH - Adolescent MH - Aged PMC - PMC11686020 OTO - NOTNLM OT - measurement OT - physical activity OT - unobtrusive observation OT - urban environments OT - video cameras OT - well-being COIS- Conflicts of Interest: None declared. EDAT- 2024/12/16 12:28 MHDA- 2024/12/16 18:18 PMCR- 2024/12/16 CRDT- 2024/12/16 11:53 PHST- 2024/09/02 00:00 [received] PHST- 2024/10/29 00:00 [accepted] PHST- 2024/10/15 00:00 [revised] PHST- 2024/12/16 18:18 [medline] PHST- 2024/12/16 12:28 [pubmed] PHST- 2024/12/16 11:53 [entrez] PHST- 2024/12/16 00:00 [pmc-release] AID - v10i1e66049 [pii] AID - 10.2196/66049 [doi] PST - epublish SO - JMIR Public Health Surveill. 2024 Dec 16;10:e66049. doi: 10.2196/66049. PMID- 39678195 OWN - NLM STAT- MEDLINE DCOM- 20241216 LR - 20250104 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 15 DP - 2024 TI - Endometrial expression of ERRbeta and ERRgamma: prognostic significance and clinical correlations in severe endometriosis. PG - 1489097 LID - 10.3389/fendo.2024.1489097 [doi] LID - 1489097 AB - BACKGROUND: Endometriosis (EMs) results in approximately 50% of reproductive-age women facing infertility. Currently, no precise model is available to predict successful postoperative pregnancy. METHODS: This study involved 81 patients with severe EMs (stages III and IV) and 38 controls with benign gynecological conditions, matched by age and BMI, diagnosis at Fujian Maternity and Child Health Hospital from January 2018 to December 2019. Relative expression levels of ERRbeta and ERRgamma mRNA in ectopic and ectopic endometrial tissues were measured using fluorescence quantitative PCR. Serum levels of ERRbeta, ERRgamma, and fertility-related hormones (AMH, FSH, LH, CA125) were assessed. Correlations were analyzed, and the predictive value of ERRgamma for postoperative pregnancy was evaluated using a nomogram based on LASSO and multivariate logistic regression. Internal validation using bootstrapping techniques assessed the nomograms performance, including calibration and DCA. RESULTS: ERRbeta and ERRgamma mRNA levels from ectopic tissues were significantly reduced in patients with severe EMs compared to controls. High serum CA125 correlated with increased ERRgamma mRNA expression in ectopic tissues. ERRgamma mRNA expression in ectopic endometrial tissues was negatively correlated with age, BMI, and FSH levels, and positively with AMH and LH/FSH ratio. ERRgamma mRNA and FSH were significant predictors of postoperative pregnancy, with the nomogram model showing a Brier score of 0.175 and a consistency statistic of 0.811. CONCLUSIONS: ERRbeta and ERRgamma are downregulated in ectopic tissues from severe EMs. Elevated ERRgamma mRNA expression and lower FSH levels are predictive factors for successful postoperative pregnancy. CI - Copyright (c) 2024 Wang, Guo, Xie, Tong, Qi and Wang. FAU - Wang, Zhenna AU - Wang Z AD - Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. FAU - Guo, Sang AU - Guo S AD - Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. FAU - Xie, Yi AU - Xie Y AD - Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. FAU - Tong, Yao AU - Tong Y AD - Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. FAU - Qi, Wei AU - Qi W AD - Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. FAU - Wang, Zhenhong AU - Wang Z AD - Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. LA - eng PT - Journal Article DEP - 20241129 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Receptors, Estrogen) RN - 0 (ESRRG protein, human) RN - 0 (ESRRB protein, human) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - *Endometriosis/metabolism/genetics/blood/diagnosis MH - *Receptors, Estrogen/metabolism/genetics MH - Adult MH - *Endometrium/metabolism/pathology MH - Prognosis MH - Pregnancy MH - Case-Control Studies MH - Nomograms MH - Severity of Illness Index MH - Biomarkers/blood/metabolism PMC - PMC11637862 OTO - NOTNLM OT - estrogen receptor-related receptor-beta OT - estrogen receptor-related receptor-gamma OT - infertility OT - pregnancy OT - severe endometriosis COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/12/16 17:25 MHDA- 2024/12/16 17:26 PMCR- 2024/01/01 CRDT- 2024/12/16 06:58 PHST- 2024/08/31 00:00 [received] PHST- 2024/11/18 00:00 [accepted] PHST- 2024/12/16 17:26 [medline] PHST- 2024/12/16 17:25 [pubmed] PHST- 2024/12/16 06:58 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2024.1489097 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2024 Nov 29;15:1489097. doi: 10.3389/fendo.2024.1489097. eCollection 2024. PMID- 39676465 OWN - NLM STAT- MEDLINE DCOM- 20250203 LR - 20250604 IS - 1365-2265 (Electronic) IS - 0300-0664 (Linking) VI - 102 IP - 3 DP - 2025 Mar TI - Growth Prediction Model for Prepubertal Children With Idiopathic Growth Hormone Deficiency: An Analysis of LG Growth Study Data. PG - 281-287 LID - 10.1111/cen.15178 [doi] AB - BACKGROUND: Growth hormone (GH) treatment is effective in restoring normal growth in children with GH deficiency (GHD). However, individual responses to GH treatment vary, necessitating predictive models to estimate growth outcomes. This study aimed to develop and validate a predictive model for GH treatment response during the first 2 years in patients with idiopathic GHD using the LG growth study (LGS) database. METHODS: This observational study included 669 prepubertal patients with idiopathic GHD from the LGS registry who received GH treatment for at least 2 years. Clinical and laboratory data were collected at baseline and every 6 months thereafter. Stepwise multivariate regression analysis was performed to develop prediction models for the treatment period. RESULTS: The mean age of patients with GDH was 6.0 +/- 1.8 years. Height standard deviation score (SDS) significantly increased from -2.50 +/- 0.71 to -1.66 +/- 0.71 in the first year and -1.35 +/- 0.71 in the second year. The first-year growth velocity was 9.06 +/- 1.51 cm, decreasing to 7.42 +/- 1.37 cm in the second year. The prediction models incorporated variables such as age, birth weight, bone age, initial height SDS, body mass index SDS, mid-parental height, GH dose and first year of height after GH treatment, explaining 76.9% and 84.1% of the variability in height SDS changes in the first and second years, respectively. CONCLUSIONS: GH treatment significantly improves height outcomes in prepubertal children with GHD. The developed predictive models demonstrated accuracy, facilitating personalized GH therapy. Future research should focus on refining these models and exploring the long-term effects of GH treatment in pubertal patients. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01604395. CI - (c) 2024 John Wiley & Sons Ltd. FAU - Jeong, Hwal Rim AU - Jeong HR AD - Department of Pediatrics, Soonchunhyang University College of Medicine, Cheonan, Korea. FAU - Lee, Hae Sang AU - Lee HS AD - Department of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, Suwon, Korea. FAU - Hwang, Jin Soon AU - Hwang JS AD - Department of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, Suwon, Korea. LA - eng SI - ClinicalTrials.gov/NCT01604395 PT - Journal Article PT - Observational Study DEP - 20241215 PL - England TA - Clin Endocrinol (Oxf) JT - Clinical endocrinology JID - 0346653 RN - 12629-01-5 (Human Growth Hormone) SB - IM MH - Humans MH - Child MH - Female MH - Male MH - *Human Growth Hormone/deficiency/therapeutic use MH - Body Height/drug effects MH - Child, Preschool MH - *Growth Disorders/drug therapy OTO - NOTNLM OT - growth hormone OT - growth hormone deficiency OT - prediction OT - treatment EDAT- 2024/12/16 11:35 MHDA- 2025/02/03 12:22 CRDT- 2024/12/16 02:43 PHST- 2024/11/27 00:00 [revised] PHST- 2024/08/10 00:00 [received] PHST- 2024/11/28 00:00 [accepted] PHST- 2025/02/03 12:22 [medline] PHST- 2024/12/16 11:35 [pubmed] PHST- 2024/12/16 02:43 [entrez] AID - 10.1111/cen.15178 [doi] PST - ppublish SO - Clin Endocrinol (Oxf). 2025 Mar;102(3):281-287. doi: 10.1111/cen.15178. Epub 2024 Dec 15. PMID- 39657252 OWN - NLM STAT- MEDLINE DCOM- 20250715 LR - 20251207 IS - 1945-7197 (Electronic) IS - 0021-972X (Print) IS - 0021-972X (Linking) VI - 110 IP - 8 DP - 2025 Jul 15 TI - Feasibility, Acceptability, and Validity of Home Continuous Glucose Monitoring-Based Oral Glucose Tolerance Test in Youth. PG - e2510-e2516 LID - 10.1210/clinem/dgae845 [doi] AB - CONTEXT: Home-based approaches to type 2 diabetes (T2D) screening in youth may facilitate early diagnosis. OBJECTIVE: This work aimed to evaluate feasibility, acceptability, and validity of a continuous glucose monitoring (CGM)-based oral glucose tolerance test (OGTT). METHODS: A prospective observational study was conducted at a pediatric clinical and translational research center. Participants were youth aged 8 to 18 years with overweight/obesity and prediabetes-range glycated hemoglobin A1c (HbA1c), fasting glucose, or 2-hour glucose on OGTT, and/or one or more guideline-based T2D risk factors. Participants completed two 75 g 2-hour OGTT 1) at the research center using serum samples (research-OGTT), and 2) at home using blinded CGM (home-OGTT). Feasibility: Percentage with valid home-OGTT data (date/time reported, transmitter returned). Acceptability: Survey and interview responses. Validity: Sensitivity, specificity, positive- and negative predictive value (PPV, NPV) of home- vs research-OGTT dysglycemia (fasting >/=100 mg/dL; 2-hour >/=140 mg/dL). RESULTS: Thirty-nine youth (54% female; 33% Black, 8% Hispanic/Latinx, 13% multiracial, 46% non-Hispanic White; age 14.6 +/- 2.0 years; mean body mass index 37.0 +/- 6.7 kg/m2) participated. HbA1c was 5.7% +/- 0.4%, fasting glucose 85.7 +/- 8.0 mg/dL, and 2-hour glucose 115.9 +/- 25.9 mg/dL. Thirty (77%) had valid home-OGTT data. Acceptability was high (92% excellent/great, 8% neutral). Due to higher average values on home-OGTT, sensitivity and NPV were high (>/=80%), while specificity (fasting: 10%; 2-hour: 25%) and PPV (fasting: 3.6%, 2-hour: 18.2%) were low. CONCLUSION: Home-OGTT was acceptable, but strategies to precisely capture glucose ingestion timing could improve feasibility. Alternate dysglycemia thresholds may need to be defined prior to using CGM as a method for T2D screening in youth. CI - (c) The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. See the journal About page for additional terms. FAU - Rodriguez Gonzalez, Adriana AU - Rodriguez Gonzalez A AD - Center for Pediatric Research in Obesity and Metabolism and Division of Pediatric Endocrinology, Diabetes, and Metabolism, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA. AD - UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA. FAU - Harrison, Caleb AU - Harrison C AD - Center for Pediatric Research in Obesity and Metabolism and Division of Pediatric Endocrinology, Diabetes, and Metabolism, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA. AD - UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA. FAU - Hewitt, Brianna AU - Hewitt B AD - Center for Pediatric Research in Obesity and Metabolism and Division of Pediatric Endocrinology, Diabetes, and Metabolism, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA. AD - UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA. FAU - Mejier, Jennifer L AU - Mejier JL AD - Departments of Medicine, Pediatrics, and Epidemiology, Dartmouth Geisel School of Medicine, Hanover, NH 03756, USA. FAU - Vajravelu, Mary Ellen AU - Vajravelu ME AUID- ORCID: 0000-0002-5839-7923 AD - Center for Pediatric Research in Obesity and Metabolism and Division of Pediatric Endocrinology, Diabetes, and Metabolism, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA. AD - UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA. LA - eng GR - UL1 TR001857/TR/NCATS NIH HHS/United States GR - UL1-TR-001857)/Clinical and Translational Science Institute/ GR - Endocrine Fellows Foundation/ GR - Tanner Scholar Advancing Equity Fund/ PT - Journal Article PT - Observational Study PT - Validation Study PL - United States TA - J Clin Endocrinol Metab JT - The Journal of clinical endocrinology and metabolism JID - 0375362 RN - 0 (Blood Glucose) RN - 0 (Glycated Hemoglobin) RN - 0 (hemoglobin A1c protein, human) SB - IM CIN - J Clin Endocrinol Metab. 2025 Oct 16;110(11):e3897-e3898. doi: 10.1210/clinem/dgaf068. PMID: 39883560 MH - Humans MH - Adolescent MH - Female MH - Male MH - Child MH - Glucose Tolerance Test/methods MH - Feasibility Studies MH - *Blood Glucose Self-Monitoring/methods MH - *Blood Glucose/analysis MH - *Diabetes Mellitus, Type 2/diagnosis/blood MH - Prospective Studies MH - Reproducibility of Results MH - Glycated Hemoglobin/analysis MH - *Prediabetic State/diagnosis/blood MH - *Patient Acceptance of Health Care/statistics & numerical data MH - Continuous Glucose Monitoring PMC - PMC12641520 OTO - NOTNLM OT - continuous glucose monitoring OT - obesity OT - oral glucose tolerance test OT - type 2 diabetes mellitus OT - youth EDAT- 2024/12/15 19:30 MHDA- 2025/07/15 12:29 PMCR- 2025/12/06 CRDT- 2024/12/10 17:43 PHST- 2024/09/01 00:00 [received] PHST- 2025/07/15 12:29 [medline] PHST- 2024/12/15 19:30 [pubmed] PHST- 2024/12/10 17:43 [entrez] PHST- 2025/12/06 00:00 [pmc-release] AID - 7918366 [pii] AID - dgae845 [pii] AID - 10.1210/clinem/dgae845 [doi] PST - ppublish SO - J Clin Endocrinol Metab. 2025 Jul 15;110(8):e2510-e2516. doi: 10.1210/clinem/dgae845. PMID- 39671871 OWN - NLM STAT- MEDLINE DCOM- 20250427 LR - 20250602 IS - 1476-5616 (Electronic) IS - 0033-3506 (Linking) VI - 238 DP - 2025 Jan TI - Neighborhood contributions in influencing overweight and obesity among Chinese children and adolescents: Temporal, geographical and gender variations. PG - 173-180 LID - S0033-3506(24)00496-7 [pii] LID - 10.1016/j.puhe.2024.11.024 [doi] AB - OBJECTIVE: The precise extent to which neighborhood influences childhood overweight and obesity (O/O) remains unknown. We investigated the magnitudes of neighborhood contributions to childhood O/O and explored potential temporal, geographical and gender variations. STUDY DESIGN: This was a pooled analysis using secondary survey data from six China Family Panel Studies from 2010 to 2020. METHODS: 26 262 children and adolescents aged 6-16 years residing in the low, medium and high O/O prevalence areas were included. Multilevel logistic analyses with random slopes were utilized to regress O/O on various individual and neighborhood covariates. Intraclass Correlation Coefficients were applied to quantify neighborhood contributions and 80 % Interval Odds Ratio and Proportions of Opposed Odds Ratios were used to evaluate between-neighborhood discrepancies in specific neighborhood factors. RESULTS: Overall, neighborhood accounted for 2%-8% of O/O variations. Temporally, neighborhood contributions declined from 2010 to 2016 but increased thereafter. Geographically, they were higher in medium/low prevalence areas than high prevalence areas (4%-10 % vs. 2%-6%). Compared to males, they were greater among females (3%-9% vs. 1%-7%). Neighborhood contributions in high prevalence areas have rapidly increased recently with those among males growing faster. Besides O/O prevalence areas, residence (OR: 1.12, CIs: 1.01-1.23)) and percentage of households with minimum living allowance (1.01, 1.00-1.01) were significant neighborhood factors with the effects of residence exhibited lower between-neighborhood variations (32%-43 % vs. 48%-50 %). CONCLUSION: This study empirically suggests the importance of neighborhood and supports the potential of governmental policies aiming at curbing childhood overweight/obesity through tailored neighborhood-based interventions. CI - Copyright (c) 2024 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved. FAU - Gu, Lijuan AU - Gu L AD - Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, China. Electronic address: gulj@igsnrr.ac.cn. LA - eng PT - Journal Article DEP - 20241212 PL - Netherlands TA - Public Health JT - Public health JID - 0376507 RN - Chinese people SB - IM MH - Humans MH - Child MH - Adolescent MH - Male MH - China/epidemiology MH - Female MH - *Pediatric Obesity/epidemiology MH - *Neighborhood Characteristics/statistics & numerical data MH - *Overweight/epidemiology MH - Sex Factors MH - Prevalence MH - *Residence Characteristics/statistics & numerical data MH - East Asian People OTO - NOTNLM OT - Children and adolescents OT - Heterogeneity OT - Neighborhood impacts OT - Overweight/obesity EDAT- 2024/12/14 00:24 MHDA- 2025/01/18 15:09 CRDT- 2024/12/13 18:08 PHST- 2024/07/29 00:00 [received] PHST- 2024/11/13 00:00 [accepted] PHST- 2025/01/18 15:09 [medline] PHST- 2024/12/14 00:24 [pubmed] PHST- 2024/12/13 18:08 [entrez] AID - S0033-3506(24)00496-7 [pii] AID - 10.1016/j.puhe.2024.11.024 [doi] PST - ppublish SO - Public Health. 2025 Jan;238:173-180. doi: 10.1016/j.puhe.2024.11.024. Epub 2024 Dec 12. PMID- 39666003 OWN - NLM STAT- MEDLINE DCOM- 20241212 LR - 20261010 IS - 1436-6215 (Electronic) IS - 1436-6207 (Linking) VI - 64 IP - 1 DP - 2024 Dec 12 TI - Chrononutrition behaviors and cardiometabolic risk in adolescence: an ecological momentary assessment study. PG - 44 LID - 10.1007/s00394-024-03557-x [doi] AB - PURPOSE: To investigate the potential associations between unhealthy chrononutrition behaviors (meal timing, frequency, and regularity) and their combined impact on cardiometabolic risk in adolescence. METHODS: Chrononutrition behaviors were assessed using a 7-day ecological momentary assessment (EMA). The unhealthy chrononutrition score (ranging from 0 to 8) was determined based on late meal timing, low meal frequency, and meal irregularity. The cardiometabolic (CM)-risk z score was calculated utilizing age- and sex-specific reference values for waist circumference (WC), mean arterial pressure (MAP), homeostatic model assessment of insulin resistance (HOMA-IR), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C). Restricted cubic splines were employed to estimate the dose-response relationships between the unhealthy chrononutrition score and outcomes. RESULTS: Among 458 participants [mean (SD) age, 17.9 (0.7) years; 340 (74.2%) Female], 14.3% had an unhealthy chrononutrition score >/= 6, who exhibited higher MAP (beta = 3.86; 95% CI 1.24, 6.47), higher CM-risk scores (beta = 1.80; 95% CI 0.70, 2.90), and lower HDL-C (beta = 0.18; 95% CI - 0.30, - 0.06), as opposed to those with a healthy score .85, P < .001) except for IR RFD (r = .56-.73, P < .05). For sessions 2 to 3, Fmax intraclass correlation coefficient and CV (intraclass correlation coefficient = .89-.96, CV = 5.2%-8.8%) were typically within acceptable ranges, whereas RFD (intraclass correlation coefficient = .74-.90, CV = 11.5%-18.1%) often exhibited inflated error. CONCLUSION: The supine (90 degrees ) position was the most consistent position across both measures. Load-cell technology can be confidently used to assess shoulder rotation Fmax in 3 different positions, whereas RFD should be used with caution without protocol refinement. FAU - Job, Trey D W 3rd AU - Job TDW 3rd AUID- ORCID: 0009-0007-3482-3290 AD - Athlete Training and Health, Spring, TX, USA. AD - Sports Performance Research Institute New Zealand, Auckland, New Zealand. FAU - Cross, Matthew R AU - Cross MR AUID- ORCID: 0000-0003-1579-3720 AD - Sports Performance Research Institute New Zealand, Auckland, New Zealand. FAU - Cronin, John B AU - Cronin JB AUID- ORCID: 0000-0002-8889-0911 AD - Athlete Training and Health, Spring, TX, USA. AD - Sports Performance Research Institute New Zealand, Auckland, New Zealand. LA - eng PT - Comparative Study PT - Journal Article DEP - 20241211 PL - United States TA - J Sport Rehabil JT - Journal of sport rehabilitation JID - 9206500 SB - IM MH - Humans MH - Rotation MH - Male MH - Adolescent MH - Reproducibility of Results MH - *Swimming/physiology MH - Female MH - *Muscle Strength/physiology MH - *Shoulder/physiology MH - Range of Motion, Articular/physiology OTO - NOTNLM OT - peak force OT - performance monitoring OT - rate of force development OT - shoulder rotator OT - upper-body strength assessment EDAT- 2024/12/12 00:24 MHDA- 2025/06/24 18:30 CRDT- 2024/12/11 18:42 PHST- 2024/04/11 00:00 [received] PHST- 2024/07/25 00:00 [revised] PHST- 2024/09/23 00:00 [accepted] PHST- 2025/06/24 18:30 [medline] PHST- 2024/12/12 00:24 [pubmed] PHST- 2024/12/11 18:42 [entrez] AID - 10.1123/jsr.2024-0150 [doi] PST - epublish SO - J Sport Rehabil. 2024 Dec 11;34(5):492-498. doi: 10.1123/jsr.2024-0150. Print 2025 Jul 1. PMID- 39656546 OWN - NLM STAT- MEDLINE DCOM- 20250604 LR - 20260718 IS - 1469-8749 (Electronic) IS - 0012-1622 (Linking) VI - 67 IP - 7 DP - 2025 Jul TI - Machine learning derived physical activity in preschool children with developmental coordination disorder. PG - 910-917 LID - 10.1111/dmcn.16186 [doi] AB - AIM: To compare the device-measured physical activity behaviours of preschool children with typical motor development to those with probable developmental coordination disorder (pDCD) and at risk for developmental coordination disorder (DCDr). METHOD: A total of 497 preschool children (4-5 years) in the Coordination and Activity Tracking in CHildren (CATCH) study completed repeated motor assessments and wore an ActiGraph GT3X on the right hip at baseline for 1 week. We calculated physical activity metrics from raw accelerometer data using a validated random forest classification machine learning model for preschool-age children. Analysis of variance (ANOVA) and linear regression models compared physical activity between typically developing children, children at risk for DCDr, and those with pDCD identified based on motor scores at baseline and averaged over time, accounting for age, sex, and accelerometer wear time. RESULTS: We found no differences in daily time spent sedentary, in light physical activity, or moderate-to-vigorous physical activity between typically developing children, children at risk for DCDr, and those with pDCD. However, children in the DCD groups spent less time doing ambulatory activities (walking/running) than typically developing children. Analysis of variance: baseline classification, DCDr to typically developing, run: F = 5.34, p = 0.005, classification averaged over time, DCDr to typically developing, walk: F = 5.82, p = 0.003. Regressions: DCDr compared to typically developing for walk: B = -3.47 (standard error 1.05), p < 0.001, pDCD compared to typically developing for run: B = -1.82 (standard error 0.62), p = 0.004. INTERPRETATION: Designing interventions for preschool children with motor difficulties targeting specific physical activity types (walk/run) may help mitigate physical activity intensity differences observed later in childhood. CI - (c) 2024 Mac Keith Press. FAU - Letts, Elyse AU - Letts E AUID- ORCID: 0000-0002-2543-8346 AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Canada. FAU - King-Dowling, Sara AU - King-Dowling S AUID- ORCID: 0000-0003-3670-8425 AD - INfant and Child Health Lab, Department of Family Medicine, McMaster University, Hamilton, Canada. AD - Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, USA. FAU - Kwan, Matthew Y W AU - Kwan MYW AUID- ORCID: 0000-0002-9757-2771 AD - INfant and Child Health Lab, Department of Family Medicine, McMaster University, Hamilton, Canada. AD - Faculty of Social Sciences, Child and Youth Studies, Brock University, St. Catharines, Canada. FAU - Obeid, Joyce AU - Obeid J AUID- ORCID: 0000-0002-6209-1505 AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Canada. AD - Department of Kinesiology, McMaster University, Hamilton, Canada. FAU - Cairney, John AU - Cairney J AUID- ORCID: 0000-0003-2856-3967 AD - INfant and Child Health Lab, Department of Family Medicine, McMaster University, Hamilton, Canada. AD - School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia. FAU - Trost, Stewart G AU - Trost SG AUID- ORCID: 0000-0001-9587-3944 AD - School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia. LA - eng GR - FSS-184834/CIHR/Canada GR - MOP 126015/CIHR/Canada GR - FSS-184834/CIHR/Canada GR - MOP 126015/CIHR/Canada PT - Journal Article DEP - 20241210 PL - England TA - Dev Med Child Neurol JT - Developmental medicine and child neurology JID - 0006761 SB - IM MH - Humans MH - *Machine Learning MH - Child, Preschool MH - Male MH - Female MH - *Motor Skills Disorders/physiopathology/diagnosis MH - *Exercise/physiology MH - Accelerometry EDAT- 2024/12/10 12:27 MHDA- 2025/06/04 06:27 CRDT- 2024/12/10 12:03 PHST- 2024/09/26 00:00 [revised] PHST- 2023/11/07 00:00 [received] PHST- 2024/10/22 00:00 [accepted] PHST- 2025/06/04 06:27 [medline] PHST- 2024/12/10 12:27 [pubmed] PHST- 2024/12/10 12:03 [entrez] AID - 10.1111/dmcn.16186 [doi] PST - ppublish SO - Dev Med Child Neurol. 2025 Jul;67(7):910-917. doi: 10.1111/dmcn.16186. Epub 2024 Dec 10. PMID- 39655132 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241211 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 16 IP - 11 DP - 2024 Nov TI - Assessing Dietary Habits of Saudi Patients With Type 2 Diabetes at Primary Healthcare Centers in Jeddah, Saudi Arabia. PG - e73333 LID - 10.7759/cureus.73333 [doi] LID - e73333 AB - Background Type 2 diabetes mellitus (T2DM) is a prevalent chronic metabolic disorder characterized by impaired glucose regulation. Managing T2DM requires healthy dietary habits to achieve glycemic control and reduce the risk of complications. However, T2DM patients often struggle to adhere to these patterns due to cultural practices, socioeconomic factors, and insufficient nutritional education. Saudi Arabia has the second-highest prevalence of diabetes in the Middle East and ranks seventh in the world. Aim The current study aimed to evaluate dietary habits and assess the associated factors with them, such as sociodemographic and clinical characteristics. Methods This cross-sectional, observational, survey-based study was conducted between January and July 2023. Adult patients with T2DM attending primary healthcare centers in Jeddah Second Health Cluster, Saudi Arabia, were included in the study. Pediatric patients who are not Saudi and have type I diabetes or gestational diabetes mellitus were excluded from the study. The data were collected using a validated self-administered questionnaire, the UK Diabetes and Diet Questionnaire (UKDDQ). Statistical analysis was performed using the computer program IBM SPSS (version 26.0, IBM Corp., Armonk, USA). The total score of questions from question 1 to question 24 (except questions 18, 20, 22, and 23) was calculated for everyone regarding the validated questionnaire. Comparisons between the demographic factors and UKDDQ scores (not normally distributed) were conducted using the Mann-Whitney test. A Spearman's test was done to explore the correlation between the numerical factors and the scores of the questions. The p-value less than 0.05 was considered statistically significant. Results The study included 428 Saudi patients with T2DM with a mean (standard deviation (SD)) age of 47.8 +/- 11.7 years old. More than two-thirds were overweight 165 (38.6%) and obese 124 (29.0%). Two-thirds of the patients were married 278 (65%), and most were employed 322 (75.2%). The mean (SD) of the total UKDDQ score was 2.7 +/- 0.4 out of 5. The results showed that males demonstrated better dietary habits than females, as reflected in their higher UKDDQ scores (P = 0.029). Additionally, patients with a university education or higher, as well as unemployed individuals, reported significantly better scores (P = 0.022 and P < 0.001, respectively). Furthermore, participants without a family history of diabetes had higher UKDDQ scores compared to those with such a history (P = 0.009). There was also a very weak positive correlation between age and UKDDQ scores (r = 0.135, P = 0.005). Conversely, a very weak negative correlation was found between Body Mass Index (BMI) and the number of years living with diabetes (r = -0.096), as well as between BMI and UKDDQ scores (r = -0.156), both with significant p-values (P = 0.049 and P = 0.001, respectively). Conclusions The findings underscore the complexity of factors influencing T2DM patients' dietary habits. Notably, males and participants with lower BMI, higher education, unemployment, and those without a family history or complications exhibited more favorable dietary scores. Essential approaches include tailored interventions, health literacy initiatives, community programs, family involvement, long-term follow-up, multidisciplinary care, and addressing socioeconomic barriers are crucial to improve glycemic control and preventing diabetes-related complications. CI - Copyright (c) 2024, AlEsawi et al. FAU - AlEsawi, Abidah H AU - AlEsawi AH AD - Department of Public Health, College of Medicine at Alfaisal University, Riyadh, SAU. FAU - Alsharif, Abdullah AU - Alsharif A AD - Department of Public Health, College of Medicine at Alfaisal University, Riyadh, SAU. LA - eng PT - Journal Article DEP - 20241109 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC11627120 OTO - NOTNLM OT - diabetes mellitus management OT - dietary OT - dietary control OT - health-care policy OT - holistic approaches OT - nutritional knowledge OT - nutritional therapy for diabetes OT - socio-economic factors OT - type 2 diabetic mellitus (t2dm) COIS- Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Jeddah Health Local Ethics Committee at the Ministry of Health issued approval A01549. Ethical approval was obtained from the Jeddah Health Local Ethics Committee at the Ministry of Health before the beginning of the study (approval number: A01549). A statement was included at the beginning of the questionnaire to indicate that this is a research study and to clarify the study objectives and targeted participants. The statement also indicated that participation in the study was completely voluntary and that the data was collected anonymously. All information provided by the study participants was kept confidential and was not shared with anyone outside the research team. No personal identifiers or names were collected. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2024/12/10 11:29 MHDA- 2024/12/10 11:30 PMCR- 2024/11/09 CRDT- 2024/12/10 04:35 PHST- 2024/11/09 00:00 [accepted] PHST- 2024/12/10 11:30 [medline] PHST- 2024/12/10 11:29 [pubmed] PHST- 2024/12/10 04:35 [entrez] PHST- 2024/11/09 00:00 [pmc-release] AID - 10.7759/cureus.73333 [doi] PST - epublish SO - Cureus. 2024 Nov 9;16(11):e73333. doi: 10.7759/cureus.73333. eCollection 2024 Nov. PMID- 39654134 OWN - NLM STAT- MEDLINE DCOM- 20250218 LR - 20250820 IS - 1440-1754 (Electronic) IS - 1034-4810 (Linking) VI - 61 IP - 2 DP - 2025 Feb TI - Cross-cultural validation in Greek and reliability of the Eating and Drinking Ability Classification System in children with cerebral palsy. PG - 223-229 LID - 10.1111/jpc.16739 [doi] AB - AIM: To investigate the reliability and validity of the Greek version of the Eating and Drinking Ability Classification System (EDACS) in children with cerebral palsy (CP). METHODS: The sample of the study included children with CP, aged 3-18 years and classified into Levels I-V of the Gross Motor Function Classification System (GMFCS). Parents of children with CP and speech and language therapists (SLTs) with a minimum of 5 years of clinical experience were recruited. Inter-rater reliability (IRR) between SLTs and between SLT and parent was evaluated using intraclass correlation coefficient (ICC). Validity was evaluated by investigating the potential association between the EDACS and Communication Function Classification System (CFCS) and GMFCS, using ordinal logistic regression. RESULTS: One hundred twenty-one children with CP (mean age 8.2 +/- 4.1), 72 males, GMFCS Levels I-V were included in the study. Ninety-one parents of children with CP (mean age 8.8 +/- 4.2), 54 males and 8 experienced SLTs, assessed the eating and drinking abilities of the children. The IRR between SLTs was excellent (ICC = 0.94), and between SLTs and parents was high (ICC = 0.90). Both CFCS and GMFCS were positive predictors for EDACS. CONCLUSIONS: The Greek version of EDACS is a valid and reliable tool and it can be used to classify eating and drinking ability in Greek children with CP. CI - (c) 2024 Paediatrics and Child Health Division (The Royal Australasian College of Physicians). FAU - Zarkada, Angeliki AU - Zarkada A AUID- ORCID: 0009-0004-9098-9277 AD - Department of Speech and Language Therapy, ELEPAP - Rehabilitation for the Disabled, Athens, Greece. AD - Motivaction - Rehabilitation Center for Children with Neurodevelopmental Disabilities, Athens, Greece. FAU - Dimakopoulos, Rigas AU - Dimakopoulos R AD - Motivaction - Rehabilitation Center for Children with Neurodevelopmental Disabilities, Athens, Greece. AD - Department of Physiotherapy, University of West Attica, Athens, Greece. FAU - Germani, Terpsithea AU - Germani T AD - Department of Speech and Language Therapy, ELEPAP - Rehabilitation for the Disabled, Athens, Greece. FAU - Zavlanou, Angeliki AU - Zavlanou A AD - Department of Speech and Language Therapy, ELEPAP - Rehabilitation for the Disabled, Athens, Greece. FAU - Spinou, Arietta AU - Spinou A AD - School of Life Course & Population Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK. FAU - Skouteli, Helen AU - Skouteli H AD - Department of Speech and Language Therapy, ELEPAP - Rehabilitation for the Disabled, Athens, Greece. AD - MITERA Children's Hospital, Athens, Greece. LA - eng PT - Journal Article PT - Validation Study DEP - 20241209 PL - Australia TA - J Paediatr Child Health JT - Journal of paediatrics and child health JID - 9005421 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology/classification MH - Child MH - Male MH - Female MH - Greece MH - Reproducibility of Results MH - Adolescent MH - Child, Preschool MH - Cross-Cultural Comparison MH - *Eating MH - *Drinking MH - Disability Evaluation OTO - NOTNLM OT - cerebral palsy OT - eating and drinking ability OT - functional classification system OT - reliability OT - validity EDAT- 2024/12/10 06:23 MHDA- 2025/02/18 12:25 CRDT- 2024/12/10 00:33 PHST- 2024/08/22 00:00 [revised] PHST- 2023/11/14 00:00 [received] PHST- 2024/11/25 00:00 [accepted] PHST- 2025/02/18 12:25 [medline] PHST- 2024/12/10 06:23 [pubmed] PHST- 2024/12/10 00:33 [entrez] AID - 10.1111/jpc.16739 [doi] PST - ppublish SO - J Paediatr Child Health. 2025 Feb;61(2):223-229. doi: 10.1111/jpc.16739. Epub 2024 Dec 9. PMID- 39653015 OWN - NLM STAT- MEDLINE DCOM- 20250307 LR - 20260924 IS - 1527-3792 (Electronic) IS - 0022-5347 (Print) IS - 0022-5347 (Linking) VI - 213 IP - 4 DP - 2025 Apr TI - Development of Prediction Models for Severe Pain and Urinary Symptoms After Ureteroscopy With Ureteral Stent Placement: Results From the STENTS Study and Initial Validation of Pain Interference. PG - 475-484 LID - 10.1097/JU.0000000000004370 [doi] AB - PURPOSE: We developed prediction models for severe pain and urinary symptoms after ureteroscopy with ureteral stent placement. MATERIALS AND METHODS: The development cohort included 424 adults and adolescents enrolled in the multicenter STENTS prospective cohort study who underwent ureteroscopy with stent placement for urinary stones. The validation cohort was an independent prospective cohort of 115 adults. The outcomes were severe pain intensity and pain interference, measured by the Patient-Reported Outcomes Measurement Information System, and severe urinary symptoms, measured by the Ureteral Stent Symptom Questionnaire. The top quartile of symptoms on postoperative days 1 and 3 was defined as severe. Generalized estimating equation models were used to predict severe symptoms on postoperative days 1, 3, 5, and 7 to 9 in the development cohort and severe pain interference on days 1 and 7 in the validation cohort. RESULTS: Female sex, younger age, higher BMI, baseline pain interference, number of chronic pain conditions, renal stone location, and history of anxiety predicted severe pain. In the development cohort, the C statistics were 0.83 (95% CI 0.80-0.85) for severe pain interference and 0.82 (95% CI 0.79-0.84) for severe pain intensity. A model in which baseline urinary symptoms replaced pain interference had excellent discrimination for severe urinary symptoms (C statistic 0.83; 95% CI 0.81-0.85). In the validation cohort, the C statistic was 0.7 for severe pain interference (95% CI 0.54-0.78). CONCLUSIONS: Preoperative characteristics accurately predicted severe pain and urinary symptoms after ureteroscopy with stent placement. On further validation, these models could guide clinical decisions to improve surgical outcomes. FAU - Tasian, Gregory E AU - Tasian GE AD - Department of Surgery, Division of Urology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. AD - Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. FAU - Harper, Jonathan D AU - Harper JD AD - Department of Urology, University of Washington, Seattle, Washington. FAU - Al-Khalidi, Hussein R AU - Al-Khalidi HR AD - Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina. AD - Department of Biostatistics & Bioinformatics, Duke University School of Medicine, Durham, North Carolina. FAU - Yang, Hongqiu AU - Yang H AD - Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina. FAU - Maalouf, Naim M AU - Maalouf NM AD - Department of Internal Medicine and Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas. FAU - Curatolo, Michele AU - Curatolo M AD - Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, Washington. FAU - Lai, H Henry AU - Lai HH AD - Department of Surgery (Urology), Washington University in St Louis, St Louis, Missouri. AD - Department of Anesthesiology, Washington University in St Louis, St Louis, Missouri. FAU - Desai, Alana AU - Desai A AD - Department of Surgery (Urology), Washington University in St Louis, St Louis, Missouri. FAU - Antonelli, Jodi A AU - Antonelli JA AD - Department of Urology, Duke University School of Medicine, Durham, North Carolina. FAU - Huang, Jing AU - Huang J AD - Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. FAU - Ziemba, Justin B AU - Ziemba JB AD - Department of Urology, University of Pennsylvania, Philadelphia, Pennsylvania. FAU - Wessells, Hunter AU - Wessells H AD - Department of Urology, University of Washington, Seattle, Washington. FAU - Kirkali, Ziya AU - Kirkali Z AD - National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland. FAU - Scales, Charles D Jr AU - Scales CD Jr AUID- ORCID: 0000-0002-7887-0204 AD - Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina. AD - Department of Urology, Duke University School of Medicine, Durham, North Carolina. AD - Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina. FAU - Reese, Peter P AU - Reese PP AD - Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. AD - Renal-Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. LA - eng GR - U01 DK110986/DK/NIDDK NIH HHS/United States GR - U01 DK110954/DK/NIDDK NIH HHS/United States GR - U01 DK110994/DK/NIDDK NIH HHS/United States GR - U01 DK110961/DK/NIDDK NIH HHS/United States GR - U01 DK110988/DK/NIDDK NIH HHS/United States GR - U24 DK110988/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20241209 PL - United States TA - J Urol JT - The Journal of urology JID - 0376374 SB - IM CIN - J Urol. 2025 Apr;213(4):483. doi: 10.1097/JU.0000000000004398. PMID: 39836916 MH - Humans MH - Female MH - *Stents/adverse effects MH - *Ureteroscopy/adverse effects MH - Male MH - Adult MH - Middle Aged MH - Prospective Studies MH - Adolescent MH - *Postoperative Pain/etiology/diagnosis/epidemiology MH - Pain Measurement MH - Ureter/surgery MH - Young Adult MH - Severity of Illness Index MH - Aged PMC - PMC11888894 MID - NIHMS2040358 OTO - NOTNLM OT - pain OT - prediction OT - ureteral stents OT - ureteroscopy EDAT- 2024/12/10 00:22 MHDA- 2025/03/07 12:25 PMCR- 2026/04/01 CRDT- 2024/12/09 18:23 PHST- 2025/03/07 12:25 [medline] PHST- 2024/12/10 00:22 [pubmed] PHST- 2024/12/09 18:23 [entrez] PHST- 2026/04/01 00:00 [pmc-release] AID - 10.1097/JU.0000000000004370 [doi] PST - ppublish SO - J Urol. 2025 Apr;213(4):475-484. doi: 10.1097/JU.0000000000004370. Epub 2024 Dec 9. PMID- 39652572 OWN - NLM STAT- MEDLINE DCOM- 20241209 LR - 20260929 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 12 DP - 2024 TI - The influence of origin and race location on performance in IRONMAN(R) age group triathletes. PG - e0315064 LID - 10.1371/journal.pone.0315064 [doi] LID - e0315064 AB - BACKGROUND: The IRONMAN(R) (IM) triathlon is a popular multi-sport, where age group athletes often strive to qualify for the IM World Championship in Hawaii. The aim of the present study was to investigate the location of the fastest IM racecourses for age group IM triathletes. This knowledge will help IM age group triathletes find the best racecourse, considering their strengths and weaknesses, to qualify. OBJECTIVE: To determine the fastest IM racecourse for age group IM triathletes using descriptive and predictive statistical methods. METHODS: We collected and analyzed 677,702 age group IM finishers' records from 228 countries participating in 444 IM competitions held between 2002 and 2022 across 66 event locations. Locations were ranked by average race speed (performance), and countries were sorted by number of records in the sample (participation). A predictive model was built with race finish time as the predicted variable and the triathlete's gender, age group, country of origin, event location, average air, and water temperatures in each location as predictors. The model was trained with 75% of the available data and was validated against the remaining 25%. Several model interpretability tools were used to explore how each predictor contributed to the model's predictive power, from which we intended to infer whether one or more predictors were more important than the others. RESULTS: The average race speed ranking showed IM Vitoria-Gasteiz (1 race only), IM Copenhagen (8 races), IM Hawaii (18 races), IM Tallinn (4 races) and IM Regensburg (2 races) in the first five positions. The XG Boost Regressor model analysis indicated that the IM Hawaii course was the fastest race course and that male athletes aged 35 years and younger were the fastest. Most of the finishers were competing in IM triathlons held in the US, such as IM Wisconsin, IM Florida, IM Lake Placid, IM Arizona, and IM Hawaii, where the IM World Championship took place. However, the fastest average times were achieved in IM Vitoria-Gasteiz, IM Copenhagen, IM Hawaii, IM Tallin, IM Regensburg, IM Brazil Florianopolis, IM Barcelona, or IM Austria with the absolutely fastest race time in IM Hawaii. Most of the successful IM finishers originated from the US, followed by athletes from the UK, Canada, Australia, Germany, and France. The best mean IM race times were achieved by athletes from Austria, Germany, Belgium, Switzerland, Finland, and Denmark. Regarding environmental conditions, the best IM race times were achieved at an air temperature of approximately 27 degrees C and a water temperature of approximately 24 degrees C. CONCLUSIONS: IM age group athletes who intend to qualify for IM World Championship in IM Hawaii are encouraged to participate in IM Austria, IM Copenhagen, IM Brazil Florianopolis, and/or IM Barcelona in order to achieve a fast race time to qualify for the IM World Championship in IM Hawaii where the top race times were achieved. Most likely these races offer the best ambient temperatures for a fast race time. CI - Copyright: (c) 2024 Knechtle et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Knechtle, Beat AU - Knechtle B AUID- ORCID: 0000-0002-2412-9103 AD - Medbase St. Gallen Am Vadianplatz, St. Gallen, Switzerland. AD - Institute of Primary Care, University of Zurich, Zurich, Switzerland. FAU - Valero, David AU - Valero D AD - Ultra Sports Science Foundation, Pierre-Benite, France. FAU - Villiger, Elias AU - Villiger E AUID- ORCID: 0000-0001-8371-1390 AD - Institute of Primary Care, University of Zurich, Zurich, Switzerland. FAU - Thuany, Mabliny AU - Thuany M AD - Department of Physical Education, State University of Para, Para, Brazil. FAU - Nikolaidis, Pantelis T AU - Nikolaidis PT AD - School of Health and Caring Sciences, University of West Attica, Athens, Greece. FAU - Cuk, Ivan AU - Cuk I AD - Faculty of Sport and Physical Education, University of Belgrade, Belgrade, Serbia. FAU - Andrade, Marilia Santos AU - Andrade MS AD - Department of Physiology, Federal University of Sao Paulo, Sao Paulo, Brazil. FAU - Forte, Pedro AU - Forte P AUID- ORCID: 0000-0003-0184-6780 AD - CI-ISCE, Higher Institute of Educational Sciences of the Douro, Penafiel, Portugal. AD - Department of Sports Sciences, Insituto Politecnico de Braganca, Braganca, Portugal. AD - Research Center in Sports Health and Human Development, Covilha, Portugal. FAU - Braschler, Lorin AU - Braschler L AD - Faculty of Medicine, University of Bern, Bern, Switzerland. FAU - Rosemann, Thomas AU - Rosemann T AD - Institute of Primary Care, University of Zurich, Zurich, Switzerland. FAU - Weiss, Katja AU - Weiss K AUID- ORCID: 0000-0003-1247-6754 AD - Institute of Primary Care, University of Zurich, Zurich, Switzerland. LA - eng PT - Journal Article DEP - 20241209 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Athletic Performance/physiology MH - Male MH - Adult MH - Female MH - Middle Aged MH - *Athletes MH - *Bicycling/statistics & numerical data MH - Hawaii MH - Young Adult MH - Running/physiology MH - Age Factors MH - Swimming/physiology MH - Aged MH - Adolescent PMC - PMC11627357 COIS- The authors have declared that no competing interests exist. EDAT- 2024/12/09 18:26 MHDA- 2024/12/09 18:27 PMCR- 2024/12/09 CRDT- 2024/12/09 13:35 PHST- 2024/06/10 00:00 [received] PHST- 2024/11/20 00:00 [accepted] PHST- 2024/12/09 18:27 [medline] PHST- 2024/12/09 18:26 [pubmed] PHST- 2024/12/09 13:35 [entrez] PHST- 2024/12/09 00:00 [pmc-release] AID - PONE-D-24-23451 [pii] AID - 10.1371/journal.pone.0315064 [doi] PST - epublish SO - PLoS One. 2024 Dec 9;19(12):e0315064. doi: 10.1371/journal.pone.0315064. eCollection 2024. PMID- 39650890 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241211 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 16 IP - 11 DP - 2024 Nov TI - Efficacy and Safety of Amiodarone and Propranolol in Pediatric Cardiology for Arrhythmia After Cardiac Surgery: A Retrospective Design Study. PG - e73102 LID - 10.7759/cureus.73102 [doi] LID - e73102 AB - Objectives The study evaluated the efficacy of antiarrhythmic pharmacotherapies in managing tachyarrhythmia episodes in pediatric patients with congenital heart diseases post-tricuspid valve repair, assessing reductions in haemodynamic parameters and symptomatic variables, and observing side effects. Methods From January 2020 to January 2024, this study reviewed data from 300 patients, aged up to 18 years, who experienced arrhythmia following cardiac surgery and received treatment with amiodarone, propranolol, or both. The information included demographic and anthropometric measures, haemodynamic parameters, and antiarrhythmic drugs used to treat arrhythmias before and after tricuspid valve repair. The study employed two validated symptomatic assessment scales: the four "A" symptomatic (4ASX) score and the New York Heart Association (NYHA) classification I-IV. We categorised the outcomes into two groups: the unresponsive cohort (Cohort I) and the responsive cohort (Cohort II). The study determined the antiarrhythmic efficacy by observing that the responsiveness group exhibited higher distribution rates in the lower heart rate category and higher decrementing rates in the tracked haemodynamics categories. The negative occurrence of at least one composited side effect of interest identified the safety significance profile for these three adopted antiarrhythmic interventions. The study adopted the threshold of 0.05 as the level of statistical significance. Results This study found that 32.33% exhibited clinical unresponsiveness to antiarrhythmic agents, while 67.67% achieved desired responsiveness. 38% used amiodarone as the choice antiarrhythmic medication, while 32.3% used propranolol. The study found significant distribution rates concerning heart rates, with 56.2% of patients with a heart rate of <100 bpm being responsive, compared to 38.1% in the unresponsive cohort. Symptomatic improvement was noted after transcatheter atrial septal defect closure in the 300 patients undergoing this procedure to address complications related to tricuspid regurgitation. Most of the adopted haemodynamic indices showed statistical significance decrementing rates in the responsiveness cohort compared to the unresponsiveness cohort. Conclusion Using antiarrhythmic pharmacotherapies during tricuspid valve repair had statistically significant responsiveness statuses against procedural arrhythmia, positive outcomes in symptomatic and haemodynamic monitored parameters, and a statistically significant noninferior safety profile regardless of the antiarrhythmic agent used (amiodarone, propranolol, or a combination of both. CI - Copyright (c) 2024, Almomani et al. FAU - Almomani, Amr AU - Almomani A AD - Pediatric Cardiology, Jordanian Royal Medical Services, Amman, JOR. FAU - Obeidat, Mohammad A AU - Obeidat MA AD - Internal Medicine, Jordanian Royal Medical Services, Amman, JOR. FAU - Khassawneh, Mohammad H AU - Khassawneh MH AD - Cardiac Surgery, Jordanian Royal Medical Services, Amman, JOR. FAU - Maayeh, Sakher M AU - Maayeh SM AD - Cardiac Surgery, Jordanian Royal Medical Services, Amman, JOR. FAU - Al-Malouf, Khaled N AU - Al-Malouf KN AD - Cardiac Surgery, Jordanian Royal Medical Services, Amman, JOR. LA - eng PT - Journal Article DEP - 20241105 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC11621723 OTO - NOTNLM OT - antiarrhythmic medication therapy OT - atrial septal defect closure OT - cardiac arrythmia OT - intravenous amiodarone OT - propranolol therapy OT - tricuspid valve repair COIS- Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Jordanian Institutional Review Board of the Royal Medical Services issued approval 17_12/2024. This study conducted a retrospective review of the findings from patients admitted to the paediatric cardiology departments at the Queen Alia Heart Institution, a tertiary referral centre for cardiology interventional specialities in our Royal Medical Services institutions, Amman, Jordan. The analysis included data from 300 patients aged up to 18 years who experienced arrhythmia following cardiac surgery and were treated with amiodarone, propranolol, or both, from January 2020 to January 2024. This study received preliminary approval from the Jordanian Royal Medical Services Institutional Review Board (JRMS_IRB) on August 13, 2024, under registration number 17_12/2024. This sanctioned study received official approval for publication following review by our institutional directorate of professional training and planning on October 8, 2024. This study meticulously adhered to the principles of the Helsinki Declaration. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2024/12/09 17:34 MHDA- 2024/12/09 17:35 PMCR- 2024/11/05 CRDT- 2024/12/09 06:21 PHST- 2024/11/05 00:00 [accepted] PHST- 2024/12/09 17:35 [medline] PHST- 2024/12/09 17:34 [pubmed] PHST- 2024/12/09 06:21 [entrez] PHST- 2024/11/05 00:00 [pmc-release] AID - 10.7759/cureus.73102 [doi] PST - epublish SO - Cureus. 2024 Nov 5;16(11):e73102. doi: 10.7759/cureus.73102. eCollection 2024 Nov. PMID- 39649773 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20251002 IS - 2689-0208 (Electronic) IS - 2689-0208 (Linking) VI - 5 IP - 3 DP - 2024 Fall TI - Validating the Problematic Media Use Measure in Preschool-Aged Children: Associations With Children's Screen Media Use, Bothersome Pestering to Use Screen Media, and Emotional Self-Regulation. LID - 10.1037/tmb0000135 [doi] AB - Screen media use, and particularly mobile device use, is frequent among preschool-age children. Studies support that problematic media use (PMU) symptoms are present among older children (4-11-year-olds) and toddlers, and PMU correlates with child temperament and parenting around child media use. We examined the performance of a widely used PMU measure among a sample of 85 3-5-year-old children to document whether variation in PMU exists in this age group and whether this PMU measure specifically has face validity relative to expected correlates of PMU. To address our study goals, we completed a confirmatory factor analysis of the PMU scale and compared PMU scores with child externalizing behaviors when parents set limits on the child's media use and three measures of child self-regulation (emotional self-regulation, attentional focusing, and inhibitory control). Results supported a one-factor construct of PMU, and PMU was positively related to greater screen time among children. Results further documented strong associations between PMU and more extreme child behaviors when limits were set on media (e.g., more bothersome pestering, crying, whining, and physical gestures). Additionally, PMU related to less emotional self-regulation among children. Overall, findings support the validity of the PMU measure in preschool-age children and confirm associations around child media use behaviors and temperament. The implications related to media parenting are discussed. FAU - Emond, Jennifer A AU - Emond JA AD - Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College. AD - Department of Pediatrics, Geisel School of Medicine, Dartmouth College. FAU - Carlson, Delaina AU - Carlson D AD - Department of Epidemiology, Geisel School of Medicine, Dartmouth College. FAU - Ballarino, Grace AU - Ballarino G AD - Department of Epidemiology, Geisel School of Medicine, Dartmouth College. FAU - Domoff, Sarah E AU - Domoff SE AD - Department of Psychology, University at Albany, State University of New York. LA - eng GR - K01 DK117971/DK/NIDDK NIH HHS/United States GR - P30 CA023108/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20240910 PL - United States TA - Technol Mind Behav JT - Technology, mind, and behavior JID - 9918250310006676 PMC - PMC11623318 MID - NIHMS2037279 OTO - NOTNLM OT - children OT - digital media OT - pestering OT - problematic media use OT - screen time COIS- Disclosures: None of the authors have a real or potential conflict of interest related to this research. EDAT- 2024/12/09 17:33 MHDA- 2024/12/09 17:34 PMCR- 2025/10/01 CRDT- 2024/12/09 06:05 PHST- 2024/12/09 17:34 [medline] PHST- 2024/12/09 17:33 [pubmed] PHST- 2024/12/09 06:05 [entrez] PHST- 2025/10/01 00:00 [pmc-release] AID - 10.1037/tmb0000135 [doi] PST - ppublish SO - Technol Mind Behav. 2024 Fall;5(3):10.1037/tmb0000135. doi: 10.1037/tmb0000135. Epub 2024 Sep 10. PMID- 39648925 OWN - NLM STAT- MEDLINE DCOM- 20250427 LR - 20250518 IS - 1465-3478 (Electronic) IS - 0963-7486 (Linking) VI - 76 IP - 2 DP - 2025 Mar TI - Are knowledge, attitudes and practices about dietary supplements and nutraceuticals related with exercise practice and setting? A cross-sectional study among Italian adults. PG - 194-202 LID - 10.1080/09637486.2024.2437468 [doi] AB - This cross-sectional study was aimed to investigate knowledge, attitudes, and practices regarding dietary supplements (DS) and nutraceuticals among athletes, gym practitioners, and individuals who did not exercise regularly. A total of 372 participants, aged 18-65, completed a questionnaire covering demographics, supplement usage, and three validated tools: the Knowledge about Dietary Supplements (KaDS), Supplements Knowledge Score (SKS), and Knowledge, Attitude, and Practice towards Nutraceuticals (KAPN). Significant differences were found in the use of vitaminised water, protein powder, glucosamines, beetroot juice, creatine, omega-3, and pre-workout supplements among the groups, with gym practitioners reporting the highest usage. Athletes scored the highest in knowledge of DS effects on health, while both athletes and gym practitioners scored higher than non-exercisers in knowledge related to sports supplements. However, all groups showed inadequate knowledge of nutraceuticals, and moderately positive attitudes towards these products. Older participants performed better in knowledge questionnaires. These findings suggest that gym practitioners, inactive and young people could benefit most from educational interventions regarding dietary supplementation. FAU - Calella, Patrizia AU - Calella P AUID- ORCID: 0000-0003-4649-0589 AD - Department of Medical, Movement and Wellbeing Sciences, University of Naples 'Parthenope', Naples, Italy. FAU - Di Dio, Mirella AU - Di Dio M AD - Department of Medical, Movement and Wellbeing Sciences, University of Naples 'Parthenope', Naples, Italy. FAU - Pelullo, Concetta Paola AU - Pelullo CP AD - Department of Medical, Movement and Wellbeing Sciences, University of Naples 'Parthenope', Naples, Italy. FAU - Di Giuseppe, Gabriella AU - Di Giuseppe G AD - Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy. FAU - Sansone, Vincenza AU - Sansone V AD - Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy. FAU - Liguori, Fabrizio AU - Liguori F AD - PhD in Linguistic, Terminological, and Intercultural Studies, Department of Economics and Legal Studies, University of Naples 'Parthenope', Naples, Italy. FAU - Di Onofrio, Valeria AU - Di Onofrio V AD - Department of Sciences and Technologies, University of Naples 'Parthenope', Naples, Italy. FAU - Valerio, Giuliana AU - Valerio G AUID- ORCID: 0000-0001-5063-4333 AD - Department of Medical, Movement and Wellbeing Sciences, University of Naples 'Parthenope', Naples, Italy. FAU - Liguori, Giorgio AU - Liguori G AD - Department of Medical, Movement and Wellbeing Sciences, University of Naples 'Parthenope', Naples, Italy. FAU - Galle, Francesca AU - Galle F AUID- ORCID: 0000-0002-0504-9562 AD - Department of Medical, Movement and Wellbeing Sciences, University of Naples 'Parthenope', Naples, Italy. LA - eng PT - Journal Article DEP - 20241209 PL - England TA - Int J Food Sci Nutr JT - International journal of food sciences and nutrition JID - 9432922 SB - IM MH - Humans MH - *Dietary Supplements MH - Adult MH - Cross-Sectional Studies MH - *Health Knowledge, Attitudes, Practice MH - Middle Aged MH - Male MH - Female MH - Italy MH - *Exercise MH - Young Adult MH - Aged MH - Adolescent MH - Surveys and Questionnaires MH - Athletes OTO - NOTNLM OT - Supplements OT - exercise OT - gym OT - nutraceutical OT - sport EDAT- 2024/12/09 06:17 MHDA- 2025/03/14 11:19 CRDT- 2024/12/09 05:23 PHST- 2025/03/14 11:19 [medline] PHST- 2024/12/09 06:17 [pubmed] PHST- 2024/12/09 05:23 [entrez] AID - 10.1080/09637486.2024.2437468 [doi] PST - ppublish SO - Int J Food Sci Nutr. 2025 Mar;76(2):194-202. doi: 10.1080/09637486.2024.2437468. Epub 2024 Dec 9. PMID- 39647841 OWN - NLM STAT- MEDLINE DCOM- 20250401 LR - 20250518 IS - 1465-3966 (Electronic) IS - 1354-8506 (Linking) VI - 30 IP - 4 DP - 2025 Apr TI - Validity and reliability of the Turkish version of the Dusseldorf orthorexia scale (TR-DOS) and the prevalence of orthorexia nervosa among Turkish university students. PG - 782-797 LID - 10.1080/13548506.2024.2439133 [doi] AB - Orthorexia Nervosa (ON) is characterized by an excessive preoccupation with healthy foods accompanied by the avoidance of self-declared unhealthy options, yet it remains unrecognized in major diagnostic guidelines. The Dusseldorf Orthorexia Scale (DOS), a 10-item self-report questionnaire using a four-point Likert scale, assesses the obsession with healthy eating. This study evaluates the reliability and validity of the TR-DOS in the Turkish context and estimates the prevalence of ON among university students. Several studies have shown that translating the DOS into various linguistic groups may exhibit different models of DOS scores. However, the psychometric properties and model fit of the DOS have not yet been investigated in Turkish-speaking populations; to address this gap, we assessed the psychometric properties of a Turkish translation of DOS (TR-DOS) in a sample of 425 university students in Turkiye. The TR-DOS revealed a 7.3% ON prevalence and a 9.0% risk of development. Weak positive associations were observed between TR-DOS total scores and BMI (r = 0.152, p = .002). Exploratory Factor Analysis confirmed the validity of TR-DOS (KMO = 0.867) with satisfactory reliability (Cronbach's alpha = 0.854). Confirmatory Factor Analysis indicated an acceptable fit for the TR-DOS model (chi2/df = 3.127, RMSEA = 0.071, SRMR = 0.046, IFI = 0.955, CFI = 0.955, GFI = 0.956, TLI = 0.932). Moderate positive correlations were found between TR-DOS and eating disorder measures (EAT-26: r = 0.428, p < .001; EDE-Q-13: r = 0.430, p < .001). The findings demonstrated that the TR-DOS is both culturally appropriate and psychometrically adequate for Turkish university students. It is a reliable and valid instrument for assessing obsessive healthy eating behaviors in this population. FAU - Kavsara, Hasan Kaan AU - Kavsara HK AUID- ORCID: 0000-0002-0322-0397 AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Yeditepe University, Istanbul, Turkiye. AD - Graduate School of Health Sciences, Nutrition and Dietetics, Istanbul Medipol University, Istanbul, Turkiye. FAU - Gul Koyuncu, Acelya AU - Gul Koyuncu A AUID- ORCID: 0000-0003-1776-1829 AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Yeditepe University, Istanbul, Turkiye. FAU - Dere Yelken, Handenaz AU - Dere Yelken H AUID- ORCID: 0000-0002-3529-3785 AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Yeditepe University, Istanbul, Turkiye. FAU - Barthels, Friederike AU - Barthels F AUID- ORCID: 0000-0003-2801-2209 AD - Department of Clinical Psychology, Institute of Experimental Psychology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany. FAU - Stroebele-Benschop, Nanette AU - Stroebele-Benschop N AUID- ORCID: 0000-0002-5835-6945 AD - Department of Nutritional Psychology, Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany. LA - eng PT - Journal Article PT - Validation Study DEP - 20241208 PL - England TA - Psychol Health Med JT - Psychology, health & medicine JID - 9604099 SB - IM MH - Humans MH - Turkey/epidemiology MH - Female MH - *Students/statistics & numerical data/psychology MH - *Feeding and Eating Disorders/epidemiology/diagnosis MH - Male MH - Reproducibility of Results MH - Young Adult MH - Universities MH - *Psychometrics/instrumentation/standards MH - Adult MH - Prevalence MH - Adolescent MH - *Feeding Behavior/psychology MH - Translations OTO - NOTNLM OT - Dusseldorf orthorexia scale OT - Orthorexia nervosa OT - eating attitudes OT - eating disorders OT - validation studies EDAT- 2024/12/09 00:22 MHDA- 2025/04/01 06:26 CRDT- 2024/12/08 19:53 PHST- 2025/04/01 06:26 [medline] PHST- 2024/12/09 00:22 [pubmed] PHST- 2024/12/08 19:53 [entrez] AID - 10.1080/13548506.2024.2439133 [doi] PST - ppublish SO - Psychol Health Med. 2025 Apr;30(4):782-797. doi: 10.1080/13548506.2024.2439133. Epub 2024 Dec 8. PMID- 39647579 OWN - NLM STAT- MEDLINE DCOM- 20250125 LR - 20260531 IS - 1095-8304 (Electronic) IS - 0195-6663 (Print) IS - 0195-6663 (Linking) VI - 206 DP - 2025 Feb 1 TI - Validation of a brief food parenting measure for fathers: A test of factorial validity, measurement invariance, internal reliability, and concurrent validity. PG - 107815 LID - S0195-6663(24)00619-6 [pii] LID - 10.1016/j.appet.2024.107815 [doi] AB - Fathers are underrepresented in food parenting research partly due to the lack of succinct, theory-informed, and father-mother equivalent food parenting measurement tools. To address this, we 1) tested the factorial validity of a brief food parenting measure utilizing a subset of items from the Comprehensive Feeding Practices Questionnaire (CFPQ) to represent coercive control, structure, and autonomy support, 2) assessed the extent to which the brief tool works similarly in fathers and mothers (i.e., measurement invariance), and 3) evaluated its internal reliability and concurrent validity. Participants included 1071 fathers of children aged 2-6 years and 487 of their co-parents (mothers) from the Fathers & Families study. Fathers and mothers responded to 16 CFPQ items, and fathers reported on children's diets. Confirmatory factor analysis (CFA) was used to test factorial validity. Multi-group CFA was used to examine measurement invariance across fathers and mothers. Internal reliability was examined using Cronbach's alpha and the Spearman-Brown coefficient. Concurrent validity was assessed utilizing multiple logistic regressions to examine associations between the three food parenting factors and children's intakes of fruit, vegetables, sugar-sweetened beverages (SSBs), and fast food. CFA confirmed a three-factor model with 11 items, including coercive control (four items), structure (five items), and autonomy support (two items). Multi-group CFA indicated measurement invariance across fathers and mothers. Internal reliability was established. Concurrent validity was strong for structure, but weaker for coercive control and autonomy support. Further refinements are encouraged to enhance items' utility in characterizing fathers' food parenting practices, including in different social and cultural contexts. CI - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Lo, Brian K AU - Lo BK AD - Department of Family Relations & Applied Nutrition, University of Guelph, Guelph, ON, N1G 2W1, Canada. Electronic address: blo02@uoguelph.ca. FAU - Park, In Young AU - Park IY AD - School of Social Work, Boston College, Chestnut Hill, MA, 02467, USA. FAU - McTernan, Melissa AU - McTernan M AD - Boston College Center for Statistics and Advanced Analysis, Chestnut Hill, MA, 02467, USA. FAU - Wang, Yilin AU - Wang Y AD - Department of Counseling, Developmental, and Educational Psychology, Boston College, Chestnut Hill, MA, 02467, USA. FAU - Cantu-Aldana, Alejandra AU - Cantu-Aldana A AD - Division of Human Genetics, The University of Texas Rio Grande Valley, Brownsville, TX, 78520, USA; South Texas Diabetes and Obesity Institute, The University of Texas Rio Grande Valley, Brownsville, TX, 78520, USA. FAU - McBride, Brent A AU - McBride BA AD - Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. FAU - Bauer, Katherine W AU - Bauer KW AD - Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA. FAU - Haines, Jess AU - Haines J AD - Department of Family Relations & Applied Nutrition, University of Guelph, Guelph, ON, N1G 2W1, Canada. FAU - Davison, Kirsten K AU - Davison KK AD - School of Social Work, Boston College, Chestnut Hill, MA, 02467, USA. LA - eng GR - P30 DK020572/DK/NIDDK NIH HHS/United States GR - R01 HD098421/HD/NICHD NIH HHS/United States PT - Journal Article PT - Validation Study DEP - 20241206 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - *Parenting/psychology MH - Male MH - *Fathers/psychology MH - Reproducibility of Results MH - Child MH - Female MH - Child, Preschool MH - Adult MH - Surveys and Questionnaires/standards MH - Factor Analysis, Statistical MH - Mothers/psychology MH - *Diet MH - *Feeding Behavior/psychology MH - Middle Aged PMC - PMC12483365 MID - NIHMS2105343 OTO - NOTNLM OT - Father OT - Food parenting OT - Measurement invariance OT - Preschool children OT - Questionnaire COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Jess Haines, Kirsten K. Davison reports financial support was provided by National Institute of Child Health and Human Development. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/12/09 00:22 MHDA- 2025/01/26 02:10 PMCR- 2025/12/06 CRDT- 2024/12/08 19:13 PHST- 2024/07/18 00:00 [received] PHST- 2024/11/16 00:00 [revised] PHST- 2024/12/05 00:00 [accepted] PHST- 2025/01/26 02:10 [medline] PHST- 2024/12/09 00:22 [pubmed] PHST- 2024/12/08 19:13 [entrez] PHST- 2025/12/06 00:00 [pmc-release] AID - S0195-6663(24)00619-6 [pii] AID - 10.1016/j.appet.2024.107815 [doi] PST - ppublish SO - Appetite. 2025 Feb 1;206:107815. doi: 10.1016/j.appet.2024.107815. Epub 2024 Dec 6. PMID- 39645399 OWN - NLM STAT- MEDLINE DCOM- 20241207 LR - 20250331 IS - 1878-2620 (Electronic) IS - 1499-4046 (Linking) VI - 56 IP - 12 DP - 2024 Dec TI - Associations Between Adolescent Food Environments and Dietary Intake. PG - 869-880 LID - S1499-4046(24)00444-5 [pii] LID - 10.1016/j.jneb.2024.09.001 [doi] AB - OBJECTIVE: To examine aspects of the home and neighborhood food environment as predictors of adolescent diet. DESIGN: Cross-sectional study. SETTING: Research laboratory in Nebraska. PARTICIPANTS: Data drawn from the adolescent phase of a larger longitudinal study. Participants included 204 adolescents (mean age of 15.3 years) and caregivers. MAIN OUTCOME MEASURES: Independent variables included the home food environment assessed via a validated questionnaire and the neighborhood food environment assessed via geographic information system methods and in-person audits. Dietary outcome variables were assessed using the Family Life, Activity, Sun, Health, and Eating questionnaire and a 24-hour recall measure. ANALYSIS: Hierarchical multiple regression analysis. P < 0.05 indicated a significant predictor. RESULTS: Home fruit and vegetable availability predicted greater Automated Self-Administered 24-hour Healthy Eating Index score (P = 0.03), greater Family Life, Activity, Sun, Health, and Eating-measured fruit and vegetable intake (P = 0.003), greater nutrient-dense food consumption (P = 0.01), and less fast-food intake (P = 0.02). Home fat and sweet availability positively predicted energy-dense, nutrient-poor food (P = 0.01), less healthful food (P < 0.001), and sugary food intake (P < 0.001). Convenience store counts positively predicted nutrient-dense food consumption (P = 0.04). Fast-food counts positively predicted sugary beverage consumption (P = 0.01). CONCLUSIONS AND IMPLICATIONS: Findings suggest that, compared with the neighborhood food environment, the home food environment displays a greater number of associations with adolescent diet. Future research is needed to determine if the home food environment may act as a modifiable intervention target to address the elevated rates of adolescent obesity. CI - Copyright (c) 2024 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved. FAU - Sarwar, Saira AU - Sarwar S AD - Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE. Electronic address: ssarwar2@huskers.unl.edu. FAU - Hill, Jennie L AU - Hill JL AD - Department of Population Health Sciences, University of Utah, Salt Lake City, UT. FAU - Yaroch, Amy Lazarus AU - Yaroch AL AD - Gretchen Swanson Center for Nutrition, Omaha, NE. FAU - Nelson, Jennifer Mize AU - Nelson JM AD - Office of Research and Economic Development, University of Nebraska-Lincoln, Lincoln, NE. FAU - Espy, Kimberly Andrews AU - Espy KA AD - Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI. FAU - Nelson, Timothy D AU - Nelson TD AD - Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE. LA - eng GR - R01 DK116693/DK/NIDDK NIH HHS/United States GR - R01 DK125651/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PL - United States TA - J Nutr Educ Behav JT - Journal of nutrition education and behavior JID - 101132622 SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - Cross-Sectional Studies MH - *Diet/statistics & numerical data MH - Feeding Behavior MH - Residence Characteristics/statistics & numerical data MH - Nebraska MH - Home Environment MH - Longitudinal Studies MH - Vegetables MH - Fruit OTO - NOTNLM OT - adolescent obesity OT - built environment OT - diet OT - nutrition EDAT- 2024/12/08 01:10 MHDA- 2024/12/08 01:11 CRDT- 2024/12/07 21:04 PHST- 2024/01/08 00:00 [received] PHST- 2024/08/30 00:00 [revised] PHST- 2024/09/07 00:00 [accepted] PHST- 2024/12/08 01:11 [medline] PHST- 2024/12/08 01:10 [pubmed] PHST- 2024/12/07 21:04 [entrez] AID - S1499-4046(24)00444-5 [pii] AID - 10.1016/j.jneb.2024.09.001 [doi] PST - ppublish SO - J Nutr Educ Behav. 2024 Dec;56(12):869-880. doi: 10.1016/j.jneb.2024.09.001. PMID- 39645083 OWN - NLM STAT- MEDLINE DCOM- 20250426 LR - 20260531 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 206 DP - 2025 Feb 1 TI - Which factors influence emotional overeating among workers and students? Is online food delivery consumption involved? Results from the DELIvery Choice In OUr Society (DELICIOUS) cross-sectional study. PG - 107814 LID - S0195-6663(24)00618-4 [pii] LID - 10.1016/j.appet.2024.107814 [doi] AB - Emotional overeating (EO) is a complex behavior that involves consuming excessive food in response to emotions, presenting health risks due to poor dietary choices. Research indicates a notable prevalence of EO, especially among females, and its association with disordered eating behaviors like binge eating (BE). The rise of online food delivery (OFD) services has raised questions about their potential role in exacerbating EO. This study aimed to explore EO behaviors among Italian workers and students, assessing the influence of various personal, socio-demographic, and lifestyle factors, including OFD. This study is a secondary data analysis utilizing the DELICIOUS survey data, conducted nationwide through social media platforms from July 12, 2022, to February 1, 2023. Participants completed validated questionnaires, including the EO Questionnaire (EOQ-5). The sample was stratified according to worker/student status. Statistical analyses, including descriptive statistics (chi-squared tests, Mann-Whitney tests) and multivariable logistic regression, were performed to assess the influence of key variables on EO. The sample comprised 2853 workers and 898 students, with almost 75% exhibiting EO behavior above the threshold. Several factors were significantly related to a higher occurrence of EO. Positive associations included bad health literacy, female gender, occasional smoking, higher BMI, depression risk for students, and low work-life balance, job dissatisfaction, screen time while eating, and depression risk for workers. Surprisingly, OFD usage showed no relationship with EO. While some findings align with previous research, like the depression-EO link, others, such as the absence of a link between OFD and EO, were unexpected. The results suggest that personal, socio-demographic, and lifestyle factors significantly influence EO, with OFD serving more as a means of food access influenced by individual characteristics, rather than a direct EO risk factor. CI - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Elhadidy, Heba Safwat Mhmoued Abdo AU - Elhadidy HSMA AD - Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy. FAU - Giacomini, Gianmarco AU - Giacomini G AD - Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy. FAU - Prinzivalli, Alessandro AU - Prinzivalli A AD - Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy. FAU - Ragusa, Paolo AU - Ragusa P AD - Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy. Electronic address: paolo.ragusa@unito.it. FAU - Gianino, Maria Michela AU - Gianino MM AD - Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy. LA - eng PT - Journal Article DEP - 20241205 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - Male MH - Cross-Sectional Studies MH - Adult MH - Italy/epidemiology MH - *Hyperphagia/psychology/epidemiology MH - *Students/psychology/statistics & numerical data MH - Young Adult MH - *Emotions MH - Surveys and Questionnaires MH - *Feeding Behavior/psychology MH - Middle Aged MH - Life Style MH - Internet MH - Risk Factors MH - Adolescent OTO - NOTNLM OT - DELICIOUS OT - Eating behaviors OT - Emotional overeating OT - Food habits OT - Online food delivery OT - Risky behaviors COIS- Declaration of competing interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/12/08 01:11 MHDA- 2025/01/26 02:11 CRDT- 2024/12/07 19:16 PHST- 2024/04/26 00:00 [received] PHST- 2024/10/15 00:00 [revised] PHST- 2024/12/03 00:00 [accepted] PHST- 2025/01/26 02:11 [medline] PHST- 2024/12/08 01:11 [pubmed] PHST- 2024/12/07 19:16 [entrez] AID - S0195-6663(24)00618-4 [pii] AID - 10.1016/j.appet.2024.107814 [doi] PST - ppublish SO - Appetite. 2025 Feb 1;206:107814. doi: 10.1016/j.appet.2024.107814. Epub 2024 Dec 5. PMID- 39643478 OWN - NLM STAT- MEDLINE DCOM- 20250425 LR - 20250502 IS - 1590-3729 (Electronic) IS - 0939-4753 (Linking) VI - 35 IP - 5 DP - 2025 May TI - Comparative analysis of adherence to 24-hour movement guidelines in adolescents: Objective versus subjective measures. PG - 103778 LID - S0939-4753(24)00397-1 [pii] LID - 10.1016/j.numecd.2024.10.016 [doi] AB - BACKGROUND AND AIMS: Previous studies have investigated the concordance between objective and subjective measures for assessing physical activity, sedentary behaviour, and sleep duration separately. However, no studies have compared adherence to the 24-h movement guidelines using both objective and subjective measures in adolescents. The aim of this study was to compare adherence to the 24-h movement guidelines using both objective and subjective measures. METHODS AND RESULTS: A comprehensive search was conducted in PubMed, Scopus, Web of Science, EMBASE, CINAHL, and SPORTDiscus up to May 2024. A meta-analysis using a random-effects model was conducted, and a p-value of <0.05 was considered statistically significant of the 5968 studies identified, only 42 met the inclusion criteria, with the included studies reporting a mean age of participants ranging from 11.99 to 17.99 years, comprising a total sample of 856,235 participants. There was no statistically significant difference between objective and self-reported measures of adherence to the 24-h movement guidelines (p > 0.05). When analysing each behaviour separately, there was a statistically significant difference between objective and self-reported measures of physical activity and sleep time (p < 0.05). Regarding sedentary behaviour, all studies used subjective measures; therefore, no meta-analysis was performed for screen time as all studies relied on subjective measures. CONCLUSION: Based on these findings, both objective and subjective measures can be used to assess adherence to the 24-h movement guidelines in adolescents. Thus, researchers and policymakers can choose either objective or subjective methods to assess adherence to the 24-h movement guidelines, with decisions tailored to the clinical context. CI - Copyright (c) 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved. FAU - Espirito Santo, Rafaela Cavalheiro do AU - Espirito Santo RCD AD - Health Research and Innovation Science Centre, Klaipeda University, Klaipeda, Lithuania. Electronic address: rafaela.santo@ku.lt. FAU - Melo, Geiziane AU - Melo G AD - Health Research and Innovation Science Centre, Klaipeda University, Klaipeda, Lithuania. FAU - Dubey, Viney Prakash AU - Dubey VP AD - Health Research and Innovation Science Centre, Klaipeda University, Klaipeda, Lithuania. FAU - Agostinis-Sobrinho, Cesar AU - Agostinis-Sobrinho C AD - Health Research and Innovation Science Centre, Klaipeda University, Klaipeda, Lithuania. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20241024 PL - Netherlands TA - Nutr Metab Cardiovasc Dis JT - Nutrition, metabolism, and cardiovascular diseases : NMCD JID - 9111474 SB - IM MH - Humans MH - Adolescent MH - *Sedentary Behavior MH - *Sleep MH - *Exercise MH - *Adolescent Behavior MH - Male MH - Time Factors MH - Female MH - Age Factors MH - Child MH - *Self Report MH - *Child Behavior MH - *Guideline Adherence/standards MH - *Healthy Lifestyle MH - *Adolescent Health MH - Predictive Value of Tests MH - Reproducibility of Results OTO - NOTNLM OT - Objective measures OT - Observational studies OT - Physical activity OT - Sedentary behaviour OT - Sleep OT - Subjective measures OT - Systematic review EDAT- 2024/12/07 14:45 MHDA- 2025/04/25 06:28 CRDT- 2024/12/06 21:53 PHST- 2024/08/16 00:00 [received] PHST- 2024/10/09 00:00 [revised] PHST- 2024/10/23 00:00 [accepted] PHST- 2025/04/25 06:28 [medline] PHST- 2024/12/07 14:45 [pubmed] PHST- 2024/12/06 21:53 [entrez] AID - S0939-4753(24)00397-1 [pii] AID - 10.1016/j.numecd.2024.10.016 [doi] PST - ppublish SO - Nutr Metab Cardiovasc Dis. 2025 May;35(5):103778. doi: 10.1016/j.numecd.2024.10.016. Epub 2024 Oct 24. PMID- 39642746 OWN - NLM STAT- MEDLINE DCOM- 20250106 LR - 20261013 IS - 1532-1983 (Electronic) IS - 0261-5614 (Linking) VI - 44 DP - 2025 Jan TI - Association between the dietary inflammatory index and the risk of hepatocellular carcinoma in a cirrhotic population. PG - 65-75 LID - S0261-5614(24)00418-7 [pii] LID - 10.1016/j.clnu.2024.11.021 [doi] AB - BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is recognized as an inflammation-related cancer. However, the relation between inflammation deriving from the diet and HCC risk among cirrhotic patients has not yet been investigated. This study aimed to examine the association between the dietary inflammatory index (DII(R)) and HCC risk among cirrhotic patients. METHODS: Clinical and dietary data were collected from the French case-control study CiRCE (Cirrhosis and Risk of hepatocellular Carcinoma in the East), which included 401 cirrhotic patients without HCC (controls) and 181 cirrhotic patients with HCC (cases) recruited between 2008 and 2012 in six French university hospitals. DII scores (36 food items and nutrients) were assessed using a validated self-administered diet history questionnaire. Odds ratios (OR) and 95 % confidence intervals (CI) were estimated with logistic regression models (adjusted for age, gender, time from cirrhosis diagnosis, etiology of cirrhosis, Child-Pugh score, and diabetes). RESULTS: The DII scores ranged between -4.77 and +7.59 with a mean value of 1.03 +/- 2.87 among cases and 0.83 +/- 2.87 among controls, indicating that both groups were following a pro-inflammatory diet. After multi-variable adjustment, there was a positive association between HCC risk and the DII score when considered as a continuous variable (OR(continuous) = 1.14 [1.02-1.27], p-value = 0.021) or categorized in tertiles (OR(T3vsT1) = 2.33 [1.16-4.67], p-trend = 0.021). Similar results were found when alcohol was omitted from the DII calculation but considered as a co-variate: OR(continuous) = 1.15 [1.03-1.28], p-value = 0.013, and OR(T3vsT1) = 2.35 [1.18-4.68], p-trend = 0.015. A positive correlation was observed between the DII scores and two inflammatory biomarkers (CRP, IL-6) among controls. CONCLUSION: The present study reported an association between a pro-inflammatory DII score and the risk of HCC in cirrhotic patients. Correlations between the scores and biological parameters support a potential role for inflammation in HCC among cirrhotic. Result should be confirmed in larger prospective studies, and could lead to nutritional prevention in cirrhotic patients. CLINICAL TRIAL REGISTRY: This study was registered in www. CLINICALTRIALS: gov as NCT01798173. CI - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Rizk, Maud AU - Rizk M AD - INSERM UMR 1231 & University of Burgundy, Dijon, France; Balamand University, Beirut, Lebanon. FAU - Roux-Levy, Cecile AU - Roux-Levy C AD - INSERM UMR 1231 & University of Burgundy, Dijon, France. FAU - Bernard-Chabert, Brigitte AU - Bernard-Chabert B AD - University Hospital, Reims, France. FAU - Bronowicki, Jean-Pierre AU - Bronowicki JP AD - University Hospital & INSERM 954, Nancy, France. FAU - Richou, Carine AU - Richou C AD - University Hospital, Besancon, France. FAU - Habersetzer, Francois AU - Habersetzer F AD - University Hospital, Strasbourg, France. FAU - Jouve, Jean-Louis AU - Jouve JL AD - University Hospital, Dijon, France. FAU - Hebert, James R AU - Hebert JR AD - Cancer Prevention and Control Program, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. FAU - Shivappa, Nitin AU - Shivappa N AD - Cancer Prevention and Control Program, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. FAU - Boutron-Ruault, Marie-Christine AU - Boutron-Ruault MC AD - INSERM, CESP Centre for Research in Epidemiology and Population Health, U1018, Lifestyle, Genes and Health: Integrative Trans-generational Epidemiology, Villejuif, F-94805, France. FAU - Diab Assaf, Mona AU - Diab Assaf M AD - Lebanese University, Beirut, Lebanon. FAU - Hillon, Patrick AU - Hillon P AD - INSERM UMR 1231 & University of Burgundy, Dijon, France; University Hospital, Dijon, France. FAU - Cottet, Vanessa AU - Cottet V AD - INSERM UMR 1231 & University of Burgundy, Dijon, France; University Hospital, Dijon, France; INSERM CIC1432 & University of Burgundy, Dijon, France. Electronic address: vanessa.cottet@u-bourgogne.fr. CN - other members of the CirCE Study group LA - eng SI - ClinicalTrials.gov/NCT01798173 PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241114 PL - England TA - Clin Nutr JT - Clinical nutrition (Edinburgh, Scotland) JID - 8309603 SB - IM MH - Humans MH - *Carcinoma, Hepatocellular/epidemiology MH - Male MH - *Liver Neoplasms/epidemiology/etiology MH - Female MH - *Liver Cirrhosis/complications/epidemiology MH - Middle Aged MH - Case-Control Studies MH - *Inflammation/complications MH - *Diet/adverse effects/statistics & numerical data MH - Risk Factors MH - Aged MH - France/epidemiology OTO - NOTNLM OT - Case-control study OT - Cirrhosis OT - DII scores OT - Hepatocellular carcinoma OT - Pro-inflammatory diet COIS- Declaration of competing interest The authors declare no conflict of interest. FIR - Di Martino, V IR - Di Martino V FIR - Doffoel, M IR - Doffoel M FIR - Thieffin, G IR - Thieffin G FIR - Binquet, C IR - Binquet C FIR - Petit, Jm IR - Petit J FIR - Minello, A IR - Minello A FIR - Latournerie, M IR - Latournerie M FIR - Sgro, C IR - Sgro C FIR - Trechot, P IR - Trechot P FIR - Valnet-Rabier, Mb IR - Valnet-Rabier M FIR - Trenque, T IR - Trenque T FIR - Tebacher-Alt, M IR - Tebacher-Alt M FIR - Faivre, J IR - Faivre J FIR - Masson, D IR - Masson D FIR - Delmas, D IR - Delmas D FIR - Duvillard, L IR - Duvillard L FIR - Gueant, Jl IR - Gueant J FIR - Jooste, V IR - Jooste V FIR - Manfait, M IR - Manfait M FIR - Oudet, P IR - Oudet P FIR - Sockalingum, G IR - Sockalingum G FIR - Vuitton, D IR - Vuitton D EDAT- 2024/12/07 14:45 MHDA- 2025/01/07 00:21 CRDT- 2024/12/06 18:09 PHST- 2024/04/22 00:00 [received] PHST- 2024/10/22 00:00 [revised] PHST- 2024/11/10 00:00 [accepted] PHST- 2025/01/07 00:21 [medline] PHST- 2024/12/07 14:45 [pubmed] PHST- 2024/12/06 18:09 [entrez] AID - S0261-5614(24)00418-7 [pii] AID - 10.1016/j.clnu.2024.11.021 [doi] PST - ppublish SO - Clin Nutr. 2025 Jan;44:65-75. doi: 10.1016/j.clnu.2024.11.021. Epub 2024 Nov 14. PMID- 39640832 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241207 IS - 2405-8440 (Print) IS - 2405-8440 (Electronic) IS - 2405-8440 (Linking) VI - 10 IP - 20 DP - 2024 Oct 30 TI - Effect of physical activity on social communication impairments in children with autism spectrum disorder: A meta-analysis. PG - e39053 LID - 10.1016/j.heliyon.2024.e39053 [doi] LID - e39053 AB - This meta-analysis aims to systematically evaluate if different physical activities (PA) improve the social communication impairments (SCI) seen in children with autism spectrum disorder (ASD). For this meta-analysis, five databases (Web of Science, PubMed and Cochrane Library database in English, and CNKI and Wanfang Data Knowledge Service Platform in Chinese) were searched from database inception to September 11, 2024. The eligibility criteria included (1) study population comprised children with ASD, with no gender restriction; (2) experimental group consisted of a PA intervention; (3) control group consisted of nonPA interventions or routine activities; (4) outcomes were assessed using validated SCI scales (e.g., social cognition, social motivation, and/or social awareness); and (5) study design involved a randomized parallel group design. The quality of the evidence for each study was assessed using the Cochrane Risk of Bias tool. From a pool of 2714 potentially relevant articles, 17 were eligible for inclusion in this review. The results of overall response of PA intervention to SCI illustrated a Medium degree of statistical heterogeneity between studies (I(2) = 53.3 %, p < 0.01); the effect size of PA intervention on SCI (expressed as standardized mean difference) was -0.34 (95 % CI: -0.57, -0.11), which was statistically significant. SCI of autistic children could be potentially improved by PA interventions, though further research is needed to clarify if benefits achieve clinical significance in addition to statistical significance. Proper design of PA interventions (45-90 min per session, more than 3 times per week and for 8-12 weeks) may enhance their effectiveness in treating SCI in children with ASD. CI - (c) 2024 The Authors. FAU - Qi, Kai AU - Qi K AD - Gdansk University of Physical Education and Sport, 80-336, Gdansk, Poland. FAU - Wang, Xiaoshuang AU - Wang X AD - College of Physical Education, Chizhou University, Chizhou, 247000, Anhui, China. FAU - Xu, Qi AU - Xu Q AD - Gdansk University of Physical Education and Sport, 80-336, Gdansk, Poland. FAU - Hu, Bingyu AU - Hu B AD - Gdansk University of Physical Education and Sport, 80-336, Gdansk, Poland. AD - Yanshan University, Qinhuangdao, 066000, Hebei, China. FAU - Wang, Ziyi AU - Wang Z AD - Gdansk University of Physical Education and Sport, 80-336, Gdansk, Poland. FAU - Bialas, Marcin AU - Bialas M AD - Gdansk University of Physical Education and Sport, 80-336, Gdansk, Poland. LA - eng PT - Journal Article DEP - 20241009 PL - England TA - Heliyon JT - Heliyon JID - 101672560 PMC - PMC11620107 OTO - NOTNLM OT - Autism spectrum disorder OT - Children OT - Physical activity OT - Social communication impairments COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/12/06 06:24 MHDA- 2024/12/06 06:25 PMCR- 2024/10/09 CRDT- 2024/12/06 05:07 PHST- 2024/01/19 00:00 [received] PHST- 2024/10/07 00:00 [revised] PHST- 2024/10/07 00:00 [accepted] PHST- 2024/12/06 06:25 [medline] PHST- 2024/12/06 06:24 [pubmed] PHST- 2024/12/06 05:07 [entrez] PHST- 2024/10/09 00:00 [pmc-release] AID - S2405-8440(24)15084-0 [pii] AID - e39053 [pii] AID - 10.1016/j.heliyon.2024.e39053 [doi] PST - epublish SO - Heliyon. 2024 Oct 9;10(20):e39053. doi: 10.1016/j.heliyon.2024.e39053. eCollection 2024 Oct 30. PMID- 39639200 OWN - NLM STAT- MEDLINE DCOM- 20241206 LR - 20260615 IS - 1471-2288 (Electronic) IS - 1471-2288 (Linking) VI - 24 IP - 1 DP - 2024 Dec 5 TI - Facilitating comprehensive child health monitoring within REDCap - an open-source code for real-time Z-score assessments. PG - 298 LID - 10.1186/s12874-024-02405-0 [doi] LID - 298 AB - BACKGROUND: Monitoring of somatic development through the assessment of anthropometric variables such as weight, height, and BMI is vital for evaluating the physical development and nutritional status of children. This approach aids in the early identification of somatic developmental disorders, enabling timely medical interventions. It traditionally relies on Z-scores, which compare anthropometric variables with reference standards. In addition to somatic development monitoring, the early detection and management of pediatric and adolescent hypertension are crucial due to potential long-term health risks. However, manual calculations of Z-scores are time-consuming and error-prone, impeding timely interventions for at-risk children. This article introduces an innovative open-code solution for real-time Z-score assessments directly within the electronic data capture platform, Research Electronic Data Capture, (REDCap), aiming to streamline the monitoring of somatic development in children. METHODS: Leveraging the World Health Organization (WHO) growth standards and National Health and Nutrition Examination Survey (NHANES) references, our approach integrates Z-score computations directly into REDCap, providing a secure and user-friendly environment for healthcare professionals and researchers. We employed Bland-Altman analyses to compare our method with established calculators (Knirps and Growth XP) using synthetic data values for all variables. RESULTS: Bland-Altman plots demonstrated strong agreement between our REDCap calculations and the Knirps and Growth XP systems. Z-scores for height, BMI, and blood pressure consistently aligned, affirming the accuracy of our approach across the measurement range. CONCLUSION: The integration with REDCap streamlines data collection and analysis, eliminating the need for separate software and data exports. Moreover, our solution uses the World Health Organization (WHO) growth standards and National Health and Nutrition Examination Survey (NHANES) references. This not only ensures calculation accuracy but also enhances its suitability for diverse research contexts. The Bland-Altman analyses establish the reliability of our method, contributing to a more effective approach to child growth and blood pressure monitoring. CI - (c) 2024. The Author(s). FAU - Mendon, Priyanka AU - Mendon P AD - Competence Centre for Methodology and Statistics, Department of Medical Informatics, Luxembourg Institute of Health, Strassen, Luxembourg. priyanka.mendon@lih.lu. FAU - Witsch, Michael AU - Witsch M AD - Pediatric Endocrinology and Diabetology, Centre Hospitalier de Luxembourg, Strassen, Luxembourg. FAU - Becker, Marianne AU - Becker M AD - Pediatric Endocrinology and Diabetology, Centre Hospitalier de Luxembourg, Strassen, Luxembourg. FAU - Adamski, Aurelie AU - Adamski A AD - Pediatric Endocrinology and Diabetology, Centre Hospitalier de Luxembourg, Strassen, Luxembourg. FAU - Vaillant, Michel AU - Vaillant M AD - Competence Centre for Methodology and Statistics, Department of Medical Informatics, Luxembourg Institute of Health, Strassen, Luxembourg. LA - eng GR - 20210404/Centre Hospitalier de Luxembourg (CHL)/ GR - 20210404/Centre Hospitalier de Luxembourg (CHL)/ GR - 20210404/Centre Hospitalier de Luxembourg (CHL)/ GR - 20210404/Centre Hospitalier de Luxembourg (CHL)/ GR - 20210404/Centre Hospitalier de Luxembourg (CHL)/ PT - Journal Article DEP - 20241205 PL - England TA - BMC Med Res Methodol JT - BMC medical research methodology JID - 100968545 SB - IM MH - Humans MH - Child MH - *Child Health MH - Female MH - Adolescent MH - Male MH - Child, Preschool MH - Body Mass Index MH - Nutrition Surveys/methods/statistics & numerical data MH - Body Height MH - Anthropometry/methods MH - Body Weight MH - Nutritional Status MH - Infant MH - Software MH - Child Development/physiology PMC - PMC11619695 OTO - NOTNLM OT - Open Code OT - REDCap OT - Real-time calculations OT - Somatic development monitoring OT - World Health Organization (WHO) growth standards OT - Z-Scores COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2024/12/06 05:30 MHDA- 2024/12/06 06:24 PMCR- 2024/12/05 CRDT- 2024/12/05 23:48 PHST- 2024/03/22 00:00 [received] PHST- 2024/11/06 00:00 [accepted] PHST- 2024/12/06 06:24 [medline] PHST- 2024/12/06 05:30 [pubmed] PHST- 2024/12/05 23:48 [entrez] PHST- 2024/12/05 00:00 [pmc-release] AID - 10.1186/s12874-024-02405-0 [pii] AID - 2405 [pii] AID - 10.1186/s12874-024-02405-0 [doi] PST - epublish SO - BMC Med Res Methodol. 2024 Dec 5;24(1):298. doi: 10.1186/s12874-024-02405-0. PMID- 39636328 OWN - NLM STAT- MEDLINE DCOM- 20241205 LR - 20250617 IS - 1522-1709 (Electronic) IS - 1520-9512 (Print) IS - 1520-9512 (Linking) VI - 29 IP - 1 DP - 2024 Dec 5 TI - Development and validation of a predictive model (CHASE-OSA) for preoperative assessment of moderate-to-severe pediatric obstructive sleep apnea. PG - 48 LID - 10.1007/s11325-024-03226-7 [doi] LID - 48 AB - PURPOSE: Undetected obstructive sleep apnea (OSA) in children increases the likelihood of perioperative respiratory complications. Current screening tools for OSA often lack sensitivity or are overly complex. This study aimed to develop and validate a simplified preoperative predictive model for moderate-to-severe pediatric OSA. METHODS: The study included children aged 1 to 18 years who underwent either polysomnography or nocturnal pulse oximetry from January 2013 to December 2020. OSA severity was categorized using these tests, and potential predictors were identified using multivariable logistic regression. The outcomes of the tests were used to create a risk-based scoring system. Internal validation was performed using bootstrapping procedures. RESULTS: Out of the 1,327 participants, 882 individuals (66.5%) were diagnosed with moderate-to-severe OSA. Predictors considered for developing the scoring system included Craniofacial abnormalities, adenotonsillar Hypertrophy, Age 1-5 years, Snoring > 5 nights/week, Excessive daytime sleepiness, Obesity, Stopping breathing, and Awakening during sleep (CHASE-OSA). The scoring system developed demonstrated an area under the receiver operating characteristic curve of 0.85 (95% CI: 0.83-0.88). The CHASE-OSA score, ranging from 0 to 14, classified scores < 6 as low-risk and >/= 6 as high-risk for moderate-to-severe pediatric OSA. This cutoff demonstrated a sensitivity of 86%, specificity of 70%, and positive and negative predictive values of 85% and 71%, respectively. CONCLUSION: The CHASE-OSA predictive model provides a concise and user-friendly preoperative screening tool for identifying moderate-to-severe pediatric OSA. It facilitates risk assessment, enhances perioperative care optimization, and informs postoperative management planning. Further research is needed to comprehensively validate its clinical utility. CI - (c) 2024. The Author(s). FAU - Unchiti, Kantarakorn AU - Unchiti K AUID- ORCID: 0000-0003-1586-1412 AD - Department of Anesthesiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. FAU - Samerchua, Artid AU - Samerchua A AUID- ORCID: 0000-0003-2556-5422 AD - Department of Anesthesiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. artidsamerchua@gmail.com. FAU - Pipanmekaporn, Tanyong AU - Pipanmekaporn T AUID- ORCID: 0000-0001-7154-5671 AD - Department of Anesthesiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. FAU - Leurcharusmee, Prangmalee AU - Leurcharusmee P AUID- ORCID: 0000-0002-3934-9002 AD - Department of Anesthesiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. FAU - Sonsuwan, Nuntigar AU - Sonsuwan N AUID- ORCID: 0000-0002-5354-1009 AD - Department of Otolaryngology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. FAU - Phinyo, Phichayut AU - Phinyo P AUID- ORCID: 0000-0002-8543-6254 AD - Center for Clinical Epidemiology and Clinical Statistics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. AD - Department of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. AD - Faculty of Medicine, Musculoskeletal Science and Translational Research (MSTR), Chiang Mai University, Chiang Mai, Thailand. FAU - Patumanond, Jayanton AU - Patumanond J AUID- ORCID: 0000-0001-8977-2995 AD - Center for Clinical Epidemiology and Clinical Statistics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. LA - eng PT - Journal Article PT - Validation Study DEP - 20241205 PL - Germany TA - Sleep Breath JT - Sleep & breathing = Schlaf & Atmung JID - 9804161 SB - IM MH - Humans MH - *Sleep Apnea, Obstructive/diagnosis MH - Child MH - Child, Preschool MH - Male MH - Female MH - Adolescent MH - Infant MH - *Polysomnography MH - Preoperative Care MH - Severity of Illness Index MH - Oximetry MH - Risk Assessment MH - Predictive Value of Tests PMC - PMC11621130 OTO - NOTNLM OT - Anesthesia OT - Obstructive OT - Pediatrics OT - Polysomnography OT - Sleep apnea COIS- Declarations. Conflict of interest: The authors have no competing interests to declare that are relevant to the content of this article. Ethical approval and consent to participate: This retrospective study which involved human participants was conducted in accordance with the ethical standards of the institutional and national research committees and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The Institutional Ethics Committee of the Faculty of Medicine, Chiang Mai University, Thailand, approved this study (ANE-2564-07977). Informed consent: For this type of study formal consent was not required. EDAT- 2024/12/05 17:31 MHDA- 2024/12/05 17:32 PMCR- 2024/12/05 CRDT- 2024/12/05 11:04 PHST- 2024/10/01 00:00 [received] PHST- 2024/12/02 00:00 [accepted] PHST- 2024/11/05 00:00 [revised] PHST- 2024/12/05 17:32 [medline] PHST- 2024/12/05 17:31 [pubmed] PHST- 2024/12/05 11:04 [entrez] PHST- 2024/12/05 00:00 [pmc-release] AID - 10.1007/s11325-024-03226-7 [pii] AID - 3226 [pii] AID - 10.1007/s11325-024-03226-7 [doi] PST - epublish SO - Sleep Breath. 2024 Dec 5;29(1):48. doi: 10.1007/s11325-024-03226-7. PMID- 39635204 OWN - NLM STAT- MEDLINE DCOM- 20241205 LR - 20241207 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 12 DP - 2024 TI - Impact of ambient air pollution on physical activity engagement among university students. PG - 1488115 LID - 10.3389/fpubh.2024.1488115 [doi] LID - 1488115 AB - INTRODUCTION: PM2.5 poses significant health risks with prolonged exposure, potentially reducing physical activity levels. This study aims to investigate the impact of ambient PM2.5 levels on physical activity engagement among individuals. METHODS: The retrospective cross-sectional study involved 423 students from Chiang Mai University residing there between January and August 2023. We used the validated Thai version of the International Physical Activity Questionnaire to assess physical activity intensity during high and low pollution periods. Individuals who engage in at least 150 min of moderate-intensity or 75 min of high-intensity physical activity per week meet the recommended physical activity guidelines. Multiple logistic regression analyzed air pollution's relation to physical activity intensity, and Cochran's Q-test compared activity levels across pollution periods. RESULTS: Recommended physical activity prevalence was 76.36% during high PM2.5 and 71.63% during low PM2.5 periods, it showed higher physical activity during polluted periods (p = 0.049). Individuals' behavior showed a preference for indoor exercise (p < 0.001), consistent PM2.5 level checks (p < 0.001) during high PM2.5 periods. Internal motivation significantly associated with recommended physical activity in both low and high PM2.5 periods (aOR = 2.46, 95% CI = 1.14 - 5.27 and aOR = 4.00, 95% CI = 1.84 - 8.70, respectively). The outdoor exercise significantly associated with the recommended physical activity only during the low PM2.5 period (aOR = 1.72, 95% CI = 1.03 - 2.87). CONCLUSION: University students showed increased physical activity intensity during high PM2.5 periods, favoring indoor exercise in polluted environments. This behavioral shift highlights environmental pollution's influence on lifestyle choices and cornering on health outcomes. Government and university support is crucial for implementing measures to mitigate PM2.5 pollution, including promoting safe indoor exercise, enhancing pollution control measures, and developing air quality monitoring and warning systems. CI - Copyright (c) 2024 Wangsan, Panumasvivat, Usanakul, Sirivoravith, Rojanachai, Zheng, Boontan and Sapbamrer. FAU - Wangsan, Kampanat AU - Wangsan K AD - Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. AD - Environmental and Occupational Medicine Excellence Center (EnOMEC), Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. FAU - Panumasvivat, Jinjuta AU - Panumasvivat J AD - Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. AD - Environmental and Occupational Medicine Excellence Center (EnOMEC), Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. FAU - Usanakul, Thiti AU - Usanakul T AD - Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. FAU - Sirivoravith, Vorapat AU - Sirivoravith V AD - Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. FAU - Rojanachai, Supanut AU - Rojanachai S AD - Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. FAU - Zheng, Natchaphol AU - Zheng N AD - Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. FAU - Boontan, Chonlathee AU - Boontan C AD - Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia. FAU - Sapbamrer, Ratana AU - Sapbamrer R AD - Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. AD - Environmental and Occupational Medicine Excellence Center (EnOMEC), Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. LA - eng PT - Journal Article DEP - 20241120 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - 0 (Particulate Matter) SB - IM MH - Humans MH - *Students/statistics & numerical data MH - Universities MH - Male MH - *Exercise MH - Cross-Sectional Studies MH - Female MH - *Air Pollution/adverse effects MH - *Particulate Matter/analysis MH - Thailand MH - Retrospective Studies MH - Young Adult MH - Surveys and Questionnaires MH - Adult MH - Environmental Exposure MH - Adolescent PMC - PMC11614755 OTO - NOTNLM OT - PM2.5 OT - air pollution OT - motivation OT - physical activity OT - university students COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer PS declared a shared affiliation with the author(s) to the handling editor at the time of review. EDAT- 2024/12/05 11:20 MHDA- 2024/12/05 17:32 PMCR- 2024/11/20 CRDT- 2024/12/05 05:46 PHST- 2024/08/29 00:00 [received] PHST- 2024/10/23 00:00 [accepted] PHST- 2024/12/05 17:32 [medline] PHST- 2024/12/05 11:20 [pubmed] PHST- 2024/12/05 05:46 [entrez] PHST- 2024/11/20 00:00 [pmc-release] AID - 10.3389/fpubh.2024.1488115 [doi] PST - epublish SO - Front Public Health. 2024 Nov 20;12:1488115. doi: 10.3389/fpubh.2024.1488115. eCollection 2024. PMID- 39631239 OWN - NLM STAT- MEDLINE DCOM- 20250109 LR - 20250422 IS - 1879-0739 (Electronic) IS - 0271-5317 (Linking) VI - 133 DP - 2025 Jan TI - Compared to dual-energy X-ray absorptiometry, bioelectrical impedance effectively monitors longitudinal changes in body composition in children and adolescents with obesity during a lifestyle intervention. PG - 1-12 LID - S0271-5317(24)00148-9 [pii] LID - 10.1016/j.nutres.2024.11.003 [doi] AB - Accurate and efficient body composition assessment is essential for diagnosing and monitoring childhood obesity in clinical and research settings. This study evaluated the agreement between bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA) in assessing body composition and its changes during a long-term lifestyle intervention in children and adolescents with obesity. We hypothesized that BIA is comparable to DXA in tracking longitudinal changes in body composition in this population. The study included 92 children and adolescents 5 to 17 years of age (mean 10.5 +/- 2.9 years) classified as obese at the time of measurement (body mass index-standard deviation score >/= 2 SD). From January 1, 2014, to December 31, 2017, they participated in a lifestyle intervention at Randers Regional Hospital. Body composition was assessed using BIA and DXA at baseline and follow-up (mean 20.5 +/- 9.3 months). Bland-Altman plots, correlation- and concordance analyses were used to evaluate the agreement between methods. Bland-Altman plots demonstrated wide limits of agreement without significant bias for longitudinal changes in fat mass (FM), FM%, fat-free mass (FFM), and FFM% (0.39 kg (CI -0.14, 0.93), -0.39% (CI -1.06, 0.26), -0.21 kg (CI -0.73, 0.31), and 0.39% (CI -0.27, 1.05), respectively). Correlations between methods for changes in FM, FM%, FFM, and FFM% were 0.93, 0.83, 0.88, and 0.83, respectively. In cross-sectional assessments, BIA underestimated FM and FM% and overestimated FFM and FFM% compared to DXA. Conclusively, BIA effectively monitors longitudinal changes in body composition at a group level in a pediatric population with obesity. However, caution is needed for individual assessments. CI - Copyright (c) 2024 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Benjaminsen, Camilla Raaby AU - Benjaminsen CR AD - Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus N, Denmark. Electronic address: 201709516@post.au.dk. FAU - Jorgensen, Rasmus Moller AU - Jorgensen RM AD - Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus N, Denmark; Department of Pediatrics, Aarhus University Hospital, Aarhus N, Denmark; Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus N, Denmark; Danish National Center for Obesity, Aarhus N, Denmark. FAU - Vestergaard, Esben Thyssen AU - Vestergaard ET AD - Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus N, Denmark; Department of Pediatrics, Aarhus University Hospital, Aarhus N, Denmark; Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus N, Denmark. FAU - Bruun, Jens Meldgaard AU - Bruun JM AD - Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus N, Denmark; Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus N, Denmark; Danish National Center for Obesity, Aarhus N, Denmark. LA - eng PT - Comparative Study PT - Journal Article DEP - 20241114 PL - United States TA - Nutr Res JT - Nutrition research (New York, N.Y.) JID - 8303331 SB - IM MH - Humans MH - *Absorptiometry, Photon MH - *Electric Impedance MH - Child MH - *Body Composition MH - Adolescent MH - Female MH - Male MH - *Pediatric Obesity/therapy MH - Longitudinal Studies MH - *Life Style MH - Child, Preschool MH - Body Mass Index OTO - NOTNLM OT - Adipose tissue OT - BIA OT - Bioelectrical impedance OT - Body composition OT - DXA OT - Dual-energy X-ray absorptiometry OT - Pediatric obesity COIS- Author declarations RMJ, ETV, and JMB are employed at Steno Diabetes Center Aarhus, a public hospital and research institution in the Central Denmark Region, partly funded by an unrestricted grant from the Novo Nordisk Foundation. CRB has no conflicts of interest to disclose. The Novo Nordisk Foundation had no role in the study's design and conduct. EDAT- 2024/12/05 05:32 MHDA- 2025/01/10 00:22 CRDT- 2024/12/04 18:06 PHST- 2024/03/26 00:00 [received] PHST- 2024/11/08 00:00 [revised] PHST- 2024/11/08 00:00 [accepted] PHST- 2025/01/10 00:22 [medline] PHST- 2024/12/05 05:32 [pubmed] PHST- 2024/12/04 18:06 [entrez] AID - S0271-5317(24)00148-9 [pii] AID - 10.1016/j.nutres.2024.11.003 [doi] PST - ppublish SO - Nutr Res. 2025 Jan;133:1-12. doi: 10.1016/j.nutres.2024.11.003. Epub 2024 Nov 14. PMID- 39630787 OWN - NLM STAT- MEDLINE DCOM- 20241204 LR - 20250130 IS - 1984-0462 (Electronic) IS - 0103-0582 (Print) IS - 0103-0582 (Linking) VI - 43 DP - 2024 TI - Instruments for evaluating parental support for the practice of physical activity in children and adolescents: A scoping review. PG - e2024025 LID - S0103-05822025000100504 [pii] LID - 10.1590/1984-0462/2025/43/2024025 [doi] LID - e2024025 AB - OBJECTIVE: The objective of this study was to map the instruments used to assess parental support for physical activity and their constructs and psychometric properties. DATA SOURCE: A scoping review was conducted, with searches in seven electronic databases and reference lists, covering articles available until April 2022. Original and cross-sectional studies were sought that used questionnaires, inventories or questions to assess parental support for the practice of physical activity and sports by children and adolescents aged 6 to 17 years and that assessed the barriers reported by parents or guardians for not offering support. DATA SYNTHESIS: Of the initial 1739 articles, 21 made up the synthesis. From a general perspective, 11 studies from 5 continents used a questionnaire or inventory or question to assess parental support; the majority of the samples evaluated were made up of girls and mothers. The intraclass correlation coefficient was the most used measure to evaluate the reliability of the instruments (10 studies). To assess the reliability of the instruments, Cronbach's alpha was the most used measure (13 studies). CONCLUSIONS: Only one instrument was constructed respecting the psychometric properties. Authors are advised to consider the importance of following the instrument validity evidence process when developing or adapting instruments. FAU - Silva, Naildo Santos AU - Silva NS AUID- ORCID: 0000-0001-6585-5307 AD - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. FAU - Guerra, Paulo Henrique AU - Guerra PH AUID- ORCID: 0000-0003-4239-0716 AD - Universidade Federal da Fronteira Sul, Chapeco, SC, Brazil. FAU - Bandeira, Paulo Felipe Ribeiro AU - Bandeira PFR AUID- ORCID: 0000-0001-8260-0189 AD - Universidade Regional do Cariri, Crato, CE, Brazil. FAU - Mello, Julio Brugnara AU - Mello JB AUID- ORCID: 0000-0002-3013-1760 AD - Pontificia Universidad Catolica de Valparaiso, Valpariso, Chile. FAU - Gaya, Adroaldo AU - Gaya A AUID- ORCID: 0000-0002-5941-5089 AD - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. LA - eng PT - Journal Article PT - Scoping Review DEP - 20241129 PL - Brazil TA - Rev Paul Pediatr JT - Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo JID - 9109353 SB - IM MH - Humans MH - Adolescent MH - Child MH - *Exercise/psychology MH - *Psychometrics/methods MH - Surveys and Questionnaires MH - *Parents/psychology MH - Reproducibility of Results MH - Female MH - Parent-Child Relations MH - Male PMC - PMC11606595 COIS- Conflict of interests: The authors declare that there is no conflict of interests. EDAT- 2024/12/04 18:22 MHDA- 2024/12/04 18:23 PMCR- 2024/11/29 CRDT- 2024/12/04 13:44 PHST- 2024/02/09 00:00 [received] PHST- 2024/07/21 00:00 [accepted] PHST- 2024/12/04 18:23 [medline] PHST- 2024/12/04 18:22 [pubmed] PHST- 2024/12/04 13:44 [entrez] PHST- 2024/11/29 00:00 [pmc-release] AID - S0103-05822025000100504 [pii] AID - 10.1590/1984-0462/2025/43/2024025 [doi] PST - epublish SO - Rev Paul Pediatr. 2024 Nov 29;43:e2024025. doi: 10.1590/1984-0462/2025/43/2024025. eCollection 2024. PMID- 39630512 OWN - NLM STAT- MEDLINE DCOM- 20250401 LR - 20261019 IS - 1556-8342 (Electronic) IS - 1556-8253 (Linking) VI - 20 IP - 4 DP - 2025 Apr TI - Test Weight Validation In Preterm Infants. PG - 238-243 LID - 10.1089/bfm.2024.0243 [doi] AB - Objective: Accuracy in the assessment of feed intake is important for preterm infants at risk of growth failure. Clinical observation tools are unvalidated in this population, and test weight measurement may be inaccurate in preterm infants taking small feed volumes. Methods: Test weights were performed to assess agreement between weights using a standardized protocol and a feed of known weight in preterm infants (born at <35 weeks gestational age [GA]) during their transition to oral feeding. Reproducibility was assessed using two repeated measurements in each participant. Agreement between test weights and known feed weights was assessed, and minimal detectable change was calculated. Results: Thirty-eight preterm infants (GA 30 + 5 (28-33 + 1), birth weight 1574 g (+/- 671 g)) were recruited and had test weights performed at CGA 35 + 3 (+/- 10 days). Each infant was weighed twice before and twice after each measured feed, and a high degree of reproducibility was found for both the paired pre-feed weights, ICC = 0.99 [0.99-0.99] and the paired post-feed weights, ICC = 0.99 [0.99-0.99]. The mean absolute difference between test weight and feed weight was 1.7 g (+/-2.2). We calculated the minimum detectable change as 0.96 g, representing the magnitude of change below which there is more than 95% chance that no real change occurred. Conclusions: During the establishment of oral feeds, a standardized protocol at the bedside for repeated pre- and post-feed weights demonstrated a high degree of reproducibility. Based on our data, test weight measurements are appropriate for use in this preterm population during the establishment of oral feeds. FAU - Kinoshita, Meredith AU - Kinoshita M AD - The Coombe Hospital, Dublin, Ireland. AD - Royal College of Surgeons Ireland, Dublin, Ireland. FAU - White, Martin J AU - White MJ AD - The Coombe Hospital, Dublin, Ireland. AD - Royal College of Surgeons Ireland, Dublin, Ireland. FAU - Doolan, Anne AU - Doolan A AUID- ORCID: 0009-0000-3649-4194 AD - The Coombe Hospital, Dublin, Ireland. AD - University College Dublin, Dublin, Ireland. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20241204 PL - United States TA - Breastfeed Med JT - Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine JID - 101260777 SB - IM MH - Humans MH - Infant, Newborn MH - *Infant, Premature/growth & development MH - Reproducibility of Results MH - Female MH - Male MH - Gestational Age MH - *Breast Feeding MH - *Body Weight MH - Infant Nutritional Physiological Phenomena MH - Birth Weight MH - *Weight Gain OTO - NOTNLM OT - breastfeeding OT - neonatology OT - preterm infant OT - test weight validation EDAT- 2024/12/04 12:28 MHDA- 2025/04/01 11:38 CRDT- 2024/12/04 12:03 PHST- 2025/04/01 11:38 [medline] PHST- 2024/12/04 12:28 [pubmed] PHST- 2024/12/04 12:03 [entrez] AID - 10.1089/bfm.2024.0243 [doi] PST - ppublish SO - Breastfeed Med. 2025 Apr;20(4):238-243. doi: 10.1089/bfm.2024.0243. Epub 2024 Dec 4. PMID- 39628133 OWN - NLM STAT- MEDLINE DCOM- 20250426 LR - 20251210 IS - 1365-2265 (Electronic) IS - 0300-0664 (Linking) VI - 102 IP - 4 DP - 2025 Apr TI - Diet Quality Scores and Central Precocious Puberty Risk in Chinese Girls: A Case-Control Study. PG - 443-452 LID - 10.1111/cen.15173 [doi] AB - OBJECTIVE: Diet is an important factor influencing central precocious puberty (CPP). This study aimed to investigate the relationship among diet quality, pro-inflammatory diets, and CPP in Chinese girls. DESIGN, PATIENTS AND MEASUREMENTS: This case-control study enroled 112 Chinese girls with CPP and 131 healthy controls. Children's dietary intake was assessed using a validated food frequency questionnaire, anthropometric and sociodemographic data were collected and serum interleukin-6 levels were measured. We calculated the Children's Dietary Inflammatory Index (C-DII), Chinese Children's Dietary Index (CCDI), Dietary Approaches to Stop Hypertension (DASH) score, and the adjusted Dietary Approaches to Stop Hypertension (aDASH) score. The association between diet and the risk of CPP was analysed using logistic regression models. RESULTS: After adjustment, higher C-DII scores were associated with an increased risk of CPP (P for trend = 0.034), and aDASH scores were significantly negatively associated with the risk of CPP (P for trend = 0.048). Serum IL-6 levels were significantly higher in the case group than in the control group and were positively correlated with the risk of CPP (P for trend = 0.006). CONCLUSIONS: High-quality dietary patterns and an anti-inflammatory diet may contribute to the prevention of CPP in Chinese girls. CI - (c) 2024 John Wiley & Sons Ltd. FAU - Qin, Yujie AU - Qin Y AUID- ORCID: 0009-0009-8954-2458 AD - Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. FAU - Deng, Hongyang AU - Deng H AD - Department of Pediatrics, Xijing Hospital, Xi'an, China. FAU - Lu, Mengnan AU - Lu M AD - Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. FAU - Liu, Lujie AU - Liu L AD - Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. FAU - Li, Meng AU - Li M AD - Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. FAU - Zhou, Jing AU - Zhou J AD - Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. FAU - Xiao, Yanfeng AU - Xiao Y AD - Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. LA - eng GR - This study was supported by the Natural Science Basic Research Plan of the Shaanxi Province (No. 2020JQ-547) and the Scientific Research Fund of the Second Affiliated Hospital of Xi'an Jiaotong University (No. YJ(QN)202006)./ PT - Journal Article DEP - 20241203 PL - England TA - Clin Endocrinol (Oxf) JT - Clinical endocrinology JID - 0346653 RN - 0 (Interleukin-6) RN - Chinese people SB - IM MH - Humans MH - Female MH - *Puberty, Precocious/epidemiology/etiology/blood MH - Case-Control Studies MH - Child MH - Interleukin-6/blood MH - *Diet MH - China/epidemiology MH - Risk Factors MH - East Asian People OTO - NOTNLM OT - IL-6 OT - central precocious puberty OT - childhood OT - diet quality OT - dietary inflammatory index OT - girls EDAT- 2024/12/04 06:23 MHDA- 2025/03/03 17:13 CRDT- 2024/12/04 02:42 PHST- 2024/07/11 00:00 [revised] PHST- 2024/03/28 00:00 [received] PHST- 2024/11/21 00:00 [accepted] PHST- 2025/03/03 17:13 [medline] PHST- 2024/12/04 06:23 [pubmed] PHST- 2024/12/04 02:42 [entrez] AID - 10.1111/cen.15173 [doi] PST - ppublish SO - Clin Endocrinol (Oxf). 2025 Apr;102(4):443-452. doi: 10.1111/cen.15173. Epub 2024 Dec 3. PMID- 39627840 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241205 IS - 2055-0928 (Electronic) IS - 2055-0928 (Linking) VI - 10 IP - 1 DP - 2024 Dec 3 TI - Uptake of preventive nutrition interventions among caretakers of children under 5 years in a pastoral setting of South Sudan. PG - 155 LID - 10.1186/s40795-024-00963-6 [doi] LID - 155 AB - BACKGROUND: Preventive nutrition interventions (PNI) are usually implemented without understanding how multilevel factors affect uptake. Undernutrition is defined as inadequate intake of nutritious foods. Pastoral populations in conflict settings are seen to have low uptake. The study assessed the level and multiple factors influencing the uptake of PNI in caregivers of under 5 in Kapoeta South County of South Sudan. METHODS: A quantitative approach was employed with an element of a qualitative in a socio-ecological framework. A total of 405 caretakers of CU5 were selected to respond to quantitative household interviews, while qualitative data was collected using KIIs. Primary data were collected through structured questionnaires, which were used to attain quantitative data. The data collected through the method of KII were of qualitative type. Using deductive thematic analysis approach, the quantitative data were coded into personal, interpersonal, and community-level factors, and the analysis was done using STATA software version 16. A technique for constructing the uptake level as low, medium, or high was factor analysis. With the result of the binary logistic regression to determine association. Furthermore, semi-structured KIIs were conducted and the qualitative information analyzed thematically to elaborate on the quantitative results. RESULT: The uptake level of the Preventive Nutrition Interventions (PNIs) was low at 51. 4%. In the socioecological system, facilitators and barriers related to this uptake differed across the benchmarks of that model. At the community level however, lack of a health facility within the community (OR = 1. 63, C. I. = 1. 02-2. 59) and the time taken before one can access a health facility (OR = 1. 70, C. I = 1. 30-2. 23) showed that accessibility could encourage uptake of PNIs. In the interpersonal dimension, joint decision makers at the family level (OR = 0. 31, C. I = 0. 19-0. 50) had higher uptake. Three factors at the individual level revealed that low uptake was inversely related to caregivers' knowledge of PNIs (OR = 0. 16, C. I. = 0. 10-0. 25), but positively related to having an undernourished child (OR = 2. 59, C. I. = 1. 73-3. 89), as well as number of children in the household (OR = 0. 40, C. I. = 0. 26). KIIs validate that undernutrition and practical issues were the main determinant of PNI uptake. CONCLUSION: This study found that caretakers of children under 5 years reported low knowledge of and uptake to preventive nutrition interventions (PNIs) among the pastoral population in South Sudan. Based on the proposed socioecological model, we recommend that PNI approaches need to target multiple levels. At the community level, the focus is on improving access to health facilities and reducing the travel time to these facilities. Another way to increase intervention uptake is to improve spousal-supported joint decisions at the interpersonal level. Enhancing the awareness of the target audience and providing them with relevant information can impact the utilization rates of PNIs at the individual level. Therefore, nutrition stakeholders should employ an approach that targets community, interpersonal, and individual levels with the purpose of increasing PNI uptake. CI - (c) 2024. The Author(s). FAU - Baluku, Walter Nehemiah AU - Baluku WN AD - Child Relief and Support Fund, Juba, South Sudan. walterbalukun@gmail.com. AD - Department of Epidemiology and Biostatistics, Makerere University School of Public Health, Kampala, Uganda. walterbalukun@gmail.com. FAU - Tabusibwa, Barbara Eva Kirunda AU - Tabusibwa BEK AD - Department of Epidemiology and Biostatistics, Makerere University School of Public Health, Kampala, Uganda. FAU - Wasswa, Ronald AU - Wasswa R AD - Department of Health Policy, Planning and Management, Makerere University School of Public Health, Kampala, Uganda. FAU - Tsadik, Shishay AU - Tsadik S AD - World Food Programme, Juba, South Sudan. FAU - Henry, Stella Guwoly AU - Henry SG AD - Action Against Hunger, Juba, South Sudan. FAU - Babughirana, Geoffrey AU - Babughirana G AD - World Vision International, Khartoum, Sudan. FAU - Kananura, Rornald Muhumuza AU - Kananura RM AD - Department of Health Policy, Planning and Management, Makerere University School of Public Health, Kampala, Uganda. AD - African Population and Health Research Center, Nairobi, Kenya. LA - eng PT - Journal Article DEP - 20241203 PL - England TA - BMC Nutr JT - BMC nutrition JID - 101672434 PMC - PMC11613845 OTO - NOTNLM OT - Nutrition uptake OT - Pastoral communities OT - Social ecological model OT - South Sudan OT - Under-5 COIS- Declarations. Ethics approval and consent to participate: Approval was obtained from the Institutional Review Board (IRB) of Makerere University School of Public Health (Reference number: ERC 1113/2017) and permission was granted by the Directorate of Planning, Budgeting and Research at the Ministry of Health in South Sudan, as well as the UNICEF Nutrition Information Working Group (NIWG). This research was performed in accordance with the Declaration of Helsinki. A detailed informed consent form was provided to the caretakers/mothers before carrying out assessments. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2024/12/04 00:23 MHDA- 2024/12/04 00:24 PMCR- 2024/12/03 CRDT- 2024/12/03 23:59 PHST- 2024/05/16 00:00 [received] PHST- 2024/11/21 00:00 [accepted] PHST- 2024/12/04 00:24 [medline] PHST- 2024/12/04 00:23 [pubmed] PHST- 2024/12/03 23:59 [entrez] PHST- 2024/12/03 00:00 [pmc-release] AID - 10.1186/s40795-024-00963-6 [pii] AID - 963 [pii] AID - 10.1186/s40795-024-00963-6 [doi] PST - epublish SO - BMC Nutr. 2024 Dec 3;10(1):155. doi: 10.1186/s40795-024-00963-6. PMID- 39627148 OWN - NLM STAT- MEDLINE DCOM- 20241203 LR - 20250114 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 14 IP - 12 DP - 2024 Dec 3 TI - Derivation and external validation of prediction model for hypertensive disorders of pregnancy in twin pregnancies: a retrospective cohort study in southeastern China. PG - e083654 LID - 10.1136/bmjopen-2023-083654 [doi] LID - e083654 AB - OBJECTIVE: We aimed to develop and validate an effective prediction model for hypertensive disorder of pregnancy (HDP) in twin pregnancies after 28 weeks of gestation. DESIGN: Retrospective cohort study. SETTING: Maternity hospital. PARTICIPANTS: We recruited twin pregnancies who delivered in Fujian Maternity and Child Health Hospital from January 2014 to December 2019 as a training cohort. Besides, we included twin pregnancies delivered at Fujian Maternity and Child Health Hospital; Women and Children's Hospital of Xiamen University from January 2020 to December 2021 as temporal validation set and geographical validation set, respectively. MAIN OUTCOME MEASURES: We performed univariate analysis, the least absolute shrinkage and selection operator regression and Boruta algorithm to screen variables. Then, we used multivariate logistic regression to construct a nomogram that predicted the risk of HDP in twin pregnancies. We employed the bootstrap resampling method for internal validation, used the receiver operating characteristic (ROC) curve to evaluate the predictive performance of the model and constructed decision curve analysis to assess the clinical benefit of the model. Thereafter validated the nomogram through the index of concordance (C-index) and calibration curves in the temporal validation set and geographical validation set. RESULTS: Multivariate logistic regression showed that primipara (OR=1.284, 95% CI=1.016 to 1.622), the higher pre-pregnancy body mass index (OR=1.077, 95% CI=1.039 to 1.116), the higher uric acid (OR=1.004, 95% CI=1.002 to 1.005), the higher urea nitrogen (OR=1.198, 95% CI=1.087 to 1.321), the higher creatinine (OR=1.011, 95% CI=1.002 to 1.020), the higher lactate dehydrogenase (OR=1.001, 95% CI=1.000 to 1.002), the higher ratio of large platelets (OR=1.034, 95% CI=1.020 to 1.048), the lower albumin (OR=0.887, 95% CI=0.852 to 0.924), the lower calcium (OR=0.148, 95% CI=0.058 to 0.375) are influencing factors of HDP in twin pregnancies. The area under the ROC curve of the prediction model was 0.763. The C-index were 0.842 and 0.746, respectively, on the temporal validation set and geographical validation set. CONCLUSIONS: The new model for predicting HDP in twin pregnancies constructed by clinical characteristics and laboratory indicators had high clinical application value. It can be used to individually evaluate the occurrence of HDP in twin pregnancies after 28 weeks of gestation. CI - (c) Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Zheng, Shuisen AU - Zheng S AD - Department of Obstetrics, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. FAU - Chen, Yujuan AU - Chen Y AD - Department of Obstetrics, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China. FAU - Gao, Yuting AU - Gao Y AD - Department of Obstetrics, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. FAU - Chen, Xiaoling AU - Chen X AD - Department of Obstetrics, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. FAU - Lin, Na AU - Lin N AD - Medical Genetic Diagnosis and Therapy Center, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China hanqing@fjmu.edu.cn linna1088@fjmu.edu.cn. FAU - Han, Qing AU - Han Q AUID- ORCID: 0000-0002-0959-2845 AD - Department of Obstetrics, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China hanqing@fjmu.edu.cn linna1088@fjmu.edu.cn. LA - eng PT - Journal Article PT - Validation Study DEP - 20241203 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Retrospective Studies MH - *Pregnancy, Twin MH - China/epidemiology MH - Adult MH - *Nomograms MH - *Hypertension, Pregnancy-Induced/diagnosis/epidemiology MH - ROC Curve MH - Risk Factors MH - Logistic Models MH - Risk Assessment/methods PMC - PMC11624755 OTO - NOTNLM OT - Hypertension OT - Maternal medicine OT - Pregnant Women COIS- Competing interests: None declared. EDAT- 2024/12/04 00:23 MHDA- 2024/12/04 00:24 PMCR- 2024/12/03 CRDT- 2024/12/03 22:03 PHST- 2024/12/04 00:24 [medline] PHST- 2024/12/04 00:23 [pubmed] PHST- 2024/12/03 22:03 [entrez] PHST- 2024/12/03 00:00 [pmc-release] AID - bmjopen-2023-083654 [pii] AID - 10.1136/bmjopen-2023-083654 [doi] PST - epublish SO - BMJ Open. 2024 Dec 3;14(12):e083654. doi: 10.1136/bmjopen-2023-083654. PMID- 39626599 OWN - NLM STAT- MEDLINE DCOM- 20250427 LR - 20250517 IS - 1878-3252 (Electronic) IS - 0946-672X (Linking) VI - 87 DP - 2025 Feb TI - Associations between serum selenium and serum lipids in adolescents aged 12-19: A cross-sectional study. PG - 127572 LID - S0946-672X(24)00192-5 [pii] LID - 10.1016/j.jtemb.2024.127572 [doi] AB - BACKGROUND: Selenium is an essential trace element in the human body and is important in lipid metabolism. Previous studies on the relationship between selenium and serum lipids were almost conducted in adults, and the research conclusions were inconsistent. Evidence linking selenium and lipids in adolescents is very limited. As an important stage of growth and development, studying the effects of trace elements on the body during adolescence is meaningful. OBJECTIVE: This study examined the association between serum selenium and serum lipids in adolescents aged 12-19. METHODS: This cross-sectional study analyzed 2209 adolescents aged 12-19 years from NHANES 2011 to 2016. Multiple linear regression analyses were performed to evaluate selenium's association with serum lipids (containing TC, TG, LDL-C, and HDL-C). Moreover, a generalized additive model (GAM) and a fitted smoothing curve (penalized spline method) were conducted to explore the exact curve shape between them. RESULTS: In the fully adjusted model, it showed a positive association between selenium and TC, TG, LDL-C [TC (beta = 0.144 (, 95 % CI (0.084, 0.204), P < 0.001), TG (beta = 0.285, 95 % CI (0.134, 0.437), P < 0.001), LDL-C (beta = 0.098, 95 % CI (0.022, 0.174), P = 0.011)], whereas a negative association [(beta = -0.031, 95 % CI (-0.054, - 0.009), P = 0.006)] between Se and HDL-C. Subgroup analysis showed that the above associations were more significant in females aged 12-19 (P for trend < 0.05). Furthermore, linear associations were performed in Se between TC and LDL-C. CONCLUSION: This is the first study to find evidence demonstrating associations between serum Se and serum lipids in adolescents aged 12-19. The validation of our findings will require further research. CI - Published by Elsevier GmbH. FAU - He, Huan AU - He H AD - Department of Ultrasound, Xi'an Jiaotong University Affiliated Children's Hospital, Xi'an, Shaanxi province, China. FAU - Yang, Li AU - Yang L AD - Department of Outpatient Office, Xi'an Jiaotong University Affiliated Children's Hospital, Xi'an, Shaanxi province, China. Electronic address: yangli_03192024@163.com. FAU - Liu, Bailing AU - Liu B AD - Department of Ultrasound, Xi'an Jiaotong University Affiliated Children's Hospital, Xi'an, Shaanxi province, China. FAU - Zhang, Zhan AU - Zhang Z AD - Department of Ultrasound, Xi'an Jiaotong University Affiliated Children's Hospital, Xi'an, Shaanxi province, China. LA - eng PT - Journal Article DEP - 20241128 PL - Germany TA - J Trace Elem Med Biol JT - Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) JID - 9508274 RN - H6241UJ22B (Selenium) RN - 0 (Lipids) SB - IM MH - Humans MH - Adolescent MH - *Selenium/blood MH - Cross-Sectional Studies MH - Female MH - Child MH - Male MH - *Lipids/blood MH - Young Adult MH - Nutrition Surveys OTO - NOTNLM OT - Adolescent OT - NHANES OT - Serum lipids OT - Serum selenium COIS- Declaration of Competing Interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/12/04 00:23 MHDA- 2025/01/31 00:21 CRDT- 2024/12/03 18:11 PHST- 2024/07/06 00:00 [received] PHST- 2024/11/09 00:00 [revised] PHST- 2024/11/26 00:00 [accepted] PHST- 2025/01/31 00:21 [medline] PHST- 2024/12/04 00:23 [pubmed] PHST- 2024/12/03 18:11 [entrez] AID - S0946-672X(24)00192-5 [pii] AID - 10.1016/j.jtemb.2024.127572 [doi] PST - ppublish SO - J Trace Elem Med Biol. 2025 Feb;87:127572. doi: 10.1016/j.jtemb.2024.127572. Epub 2024 Nov 28. PMID- 39625440 OWN - NLM STAT- MEDLINE DCOM- 20241203 LR - 20260708 IS - 1552-5783 (Electronic) IS - 0146-0404 (Print) IS - 0146-0404 (Linking) VI - 65 IP - 14 DP - 2024 Dec 2 TI - Effects of Physical Activity and Inactivity on Microvasculature in Children: The Hong Kong Children Eye Study. PG - 7 LID - 10.1167/iovs.65.14.7 [doi] LID - 7 AB - PURPOSE: The purpose of this study was to investigate the effects of physical activity and inactivity on the microvasculature in children, as measured from retinal photographs. METHODS: All participants were from the Hong Kong Children Eye Study, a population-based cross-sectional study of children aged 6 to 8 years. They received comprehensive ophthalmic examinations and retinal photography. Their demographics and involvement in physical activity and inactivity were obtained from validated questionnaires. A validated Deep Learning System was used to measure, from retinal photographs, central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE). RESULTS: In the final analysis of 11,959 participants, 6244 (52.2%) were boys and the mean age was 7.55 (1.05) years. Increased ratio of physical activity to inactivity was associated with wider CRAE (beta = 1.033, P = 0.007) and narrower CRVE (beta = -2.079, P < 0.001). In the subgroup analysis of boys, increased ratio of physical activity to inactivity was associated with wider CRAE (beta = 1.364, P = 0.013) and narrower CRVE (beta = -2.563, P = 0.001). The subgroup analysis of girls also showed increased ratio of physical activity to inactivity was associated with narrower CRVE (beta = -1.759, P = 0.020), but not CRAE. CONCLUSIONS: Increased activity in children is associated with healthier microvasculature, as shown in the retina. Our study contributes to the growing evidence that physical activity positively influences vascular health from a young age. Therefore, this study also underscores the potential of using the retinal vasculature as a biomarker of cardiovascular health. FAU - Zhang, Xiu Juan AU - Zhang XJ AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. AD - Department of Ophthalmology, University of Hong Kong, Hong Kong SAR, China. FAU - Yuen, Vincent L AU - Yuen VL AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. FAU - Zhang, Yuzhou AU - Zhang Y AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. FAU - Kam, Ka Wai AU - Kam KW AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. AD - Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong SAR, China. FAU - Wong, Jason AU - Wong J AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. FAU - Tang, Fang Yao AU - Tang FY AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. FAU - Young, Alvin AU - Young A AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. AD - Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong SAR, China. FAU - Ip, Patrick AU - Ip P AD - Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong SAR, China. FAU - Chen, Li Jia AU - Chen LJ AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. AD - Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong SAR, China. AD - Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong SAR, China. FAU - Wong, Tien Y AU - Wong TY AD - Singapore Eye Research Institute, Singapore National Eye Center, Singapore. AD - Tsinghua Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China. FAU - Pang, Chi Pui AU - Pang CP AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. AD - Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong SAR, China. FAU - Tham, Clement C AU - Tham CC AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. AD - Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong SAR, China. AD - Hong Kong Eye Hospital, Kowloon, Hong Kong SAR, China. AD - Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong SAR, China. FAU - Cheung, Carol Y AU - Cheung CY AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. FAU - Yam, Jason C AU - Yam JC AD - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. AD - Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong SAR, China. AD - Hong Kong Eye Hospital, Kowloon, Hong Kong SAR, China. AD - Department of Ophthalmology, Hong Kong Children's Hospital, Hong Kong SAR, China. AD - Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong SAR, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Invest Ophthalmol Vis Sci JT - Investigative ophthalmology & visual science JID - 7703701 SB - IM MH - Humans MH - Male MH - Female MH - Child MH - Cross-Sectional Studies MH - Hong Kong/epidemiology MH - *Exercise/physiology MH - *Retinal Vessels/physiology/diagnostic imaging MH - *Microvessels/physiology MH - Sedentary Behavior MH - Surveys and Questionnaires PMC - PMC11620007 COIS- Disclosure: X.J. Zhang, None; V.L. Yuen, None; Y. Zhang, None; K.W. Kam, None; J. Wong, None; F.Y. Tang, None; A. Young, None; P. Ip, None; L.J. Chen, None; T.Y. Wong, None; C.P. Pang, None; C.C. Tham, None; C.Y. Cheung, None; J.C. Yam, None EDAT- 2024/12/03 12:26 MHDA- 2024/12/03 12:27 PMCR- 2024/12/03 CRDT- 2024/12/03 10:33 PHST- 2024/12/03 12:27 [medline] PHST- 2024/12/03 12:26 [pubmed] PHST- 2024/12/03 10:33 [entrez] PHST- 2024/12/03 00:00 [pmc-release] AID - 2802309 [pii] AID - IOVS-24-40635 [pii] AID - 10.1167/iovs.65.14.7 [doi] PST - ppublish SO - Invest Ophthalmol Vis Sci. 2024 Dec 2;65(14):7. doi: 10.1167/iovs.65.14.7. PMID- 39624369 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241203 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 15 DP - 2024 TI - Corrigendum: Development and validation of the Chinese family environment influencing physical activity habits scale. PG - 1521605 LID - 10.3389/fpsyg.2024.1521605 [doi] LID - 1521605 AB - [This corrects the article DOI: 10.3389/fpsyg.2023.1243658.]. CI - Copyright (c) 2024 Zhang, Yan, Zhu and Fu. FAU - Zhang, Xulin AU - Zhang X AD - College of Physical Education and Health, East China Normal University, Shanghai, China. FAU - Yan, Jingfei AU - Yan J AD - Ministry of Physical Education, Shanghai Institute of Technology, Shanghai, China. FAU - Zhu, Weiqiang AU - Zhu W AD - College of Physical Education and Health, East China Normal University, Shanghai, China. FAU - Fu, Xiaoya AU - Fu X AD - College of Physical Education, Ningxia Normal University, Guyuan, China. LA - eng PT - Published Erratum DEP - 20241118 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 EFR - Front Psychol. 2024 Jan 16;14:1243658. doi: 10.3389/fpsyg.2023.1243658. PMID: 38292523 PMC - PMC11609434 OTO - NOTNLM OT - Chinese adolescents OT - factor analysis OT - family environment OT - physical activity habit OT - scale development EDAT- 2024/12/03 06:24 MHDA- 2024/12/03 06:25 PMCR- 2024/11/18 CRDT- 2024/12/03 04:21 PHST- 2024/11/04 00:00 [received] PHST- 2024/11/04 00:00 [accepted] PHST- 2024/12/03 06:25 [medline] PHST- 2024/12/03 06:24 [pubmed] PHST- 2024/12/03 04:21 [entrez] PHST- 2024/11/18 00:00 [pmc-release] AID - 10.3389/fpsyg.2024.1521605 [doi] PST - epublish SO - Front Psychol. 2024 Nov 18;15:1521605. doi: 10.3389/fpsyg.2024.1521605. eCollection 2024. PMID- 39623765 OWN - NLM STAT- MEDLINE DCOM- 20250510 LR - 20260721 IS - 1469-7610 (Electronic) IS - 0021-9630 (Print) IS - 0021-9630 (Linking) VI - 66 IP - 6 DP - 2025 Jun TI - Neural correlates of children with avoidant restrictive food intake disorder symptoms: large-scale neuroanatomical analysis of a paediatric population. PG - 785-795 LID - 10.1111/jcpp.14086 [doi] AB - BACKGROUND: Avoidant restrictive food intake disorder (ARFID) is a recently recognised feeding and eating disorder and is characterised by a lack of interest and motivation to eat. Despite burgeoning research, few studies to date have explored the underlying neurobiology of ARFID. Research examining the neural underpinnings of ARFID can greatly assist in understanding different mechanisms that play disorder-specific roles. METHODS: We studied a total of 1,977 10-year-old participants from the Generation R Study, a population-based Dutch cohort, to cross-sectionally examine neuroanatomical differences between those with versus without ARFID-like symptoms. Children were classified with versus without ARFID symptoms using the ARFID Index, a validated evaluative tool comprised of parent-reported and researcher-assessed measurements of picky eating, energy intake, diet quality, growth and psychosocial impact to characterise ARFID symptoms in the paediatric population. Global and regional values of surface area, cortical thickness, and volume from T(1)-weighted structural magnetic resonance imaging (MRI) scans in those with ARFID symptoms were compared with children not exhibiting symptoms. RESULTS: We identified 121 (6.1%) individuals with ARFID symptoms relative to 1,865 (93.9%) individuals without ARFID symptoms. Neuroanatomical findings identified significantly greater frontal (p = .00743; d = 0.21) and superior frontal (p = 6.56E-04; d = 0.28) cortical thickness among children with ARFID symptoms. CONCLUSIONS: This first large-scale study of the neural correlates of ARFID identified greater thickness of frontal cortical regions in children with ARFID symptoms, suggesting a role for executive function in the aetiology of the condition. CI - (c) 2024 The Author(s). Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health. FAU - Sader, Michelle AU - Sader M AUID- ORCID: 0000-0002-8068-7337 AD - University of Aberdeen, Aberdeen, UK. FAU - Harris, Holly A AU - Harris HA AD - Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands. AD - Erasmus University Rotterdam, Rotterdam, The Netherlands. FAU - Waiter, Gordon D AU - Waiter GD AD - University of Aberdeen, Aberdeen, UK. FAU - Jansen, Pauline W AU - Jansen PW AD - Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands. AD - Erasmus University Rotterdam, Rotterdam, The Netherlands. FAU - Williams, Justin H G AU - Williams JHG AD - University of Aberdeen, Aberdeen, UK. AD - Griffith University, Gold Coast, Queensland, Australia. AD - Gold Coast Mental Health and Specialist Services, Gold Coast, Queensland, Australia. FAU - White, Tonya AU - White T AD - Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands. AD - Section on Social and Cognitive Developmental Neuroscience, National Institute of Mental Health, Bethesda, Maryland, USA. LA - eng GR - Z99 MH999999/ImNIH/Intramural NIH HHS/United States GR - ZIA MH002986/ImNIH/Intramural NIH HHS/United States GR - RG15207; RG13425/Northwood Charitable Trust/ PT - Journal Article PT - Research Support, N.I.H., Intramural PT - Research Support, Non-U.S. Gov't DEP - 20241202 PL - England TA - J Child Psychol Psychiatry JT - Journal of child psychology and psychiatry, and allied disciplines JID - 0375361 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - Magnetic Resonance Imaging MH - *Avoidant Restrictive Food Intake Disorder/diagnostic imaging/pathology/physiopathology MH - Cross-Sectional Studies MH - Netherlands MH - *Cerebral Cortex/diagnostic imaging/pathology PMC - PMC12062856 MID - NIHMS2038513 OTO - NOTNLM OT - ARFID OT - BMI OT - MRI OT - eating disorders OT - hunger awareness OT - neuroanatomy EDAT- 2024/12/03 06:24 MHDA- 2025/05/11 00:44 PMCR- 2025/05/09 CRDT- 2024/12/03 02:02 PHST- 2024/09/16 00:00 [accepted] PHST- 2025/05/11 00:44 [medline] PHST- 2024/12/03 06:24 [pubmed] PHST- 2024/12/03 02:02 [entrez] PHST- 2025/05/09 00:00 [pmc-release] AID - JCPP14086 [pii] AID - 10.1111/jcpp.14086 [doi] PST - ppublish SO - J Child Psychol Psychiatry. 2025 Jun;66(6):785-795. doi: 10.1111/jcpp.14086. Epub 2024 Dec 2. PMID- 39623435 OWN - NLM STAT- MEDLINE DCOM- 20241203 LR - 20260903 IS - 1472-6947 (Electronic) IS - 1472-6947 (Linking) VI - 24 IP - 1 DP - 2024 Dec 2 TI - Predictive modelling of linear growth faltering among pediatric patients with Diarrhea in Rural Western Kenya: an explainable machine learning approach. PG - 368 LID - 10.1186/s12911-024-02779-7 [doi] LID - 368 AB - INTRODUCTION: Stunting affects one-fifth of children globally with diarrhea accounting for an estimated 13.5% of stunting. Identifying risk factors for its precursor, linear growth faltering (LGF), is critical to designing interventions. Moreover, developing new predictive models for LGF using more recent data offers opportunity to enhance model accuracy, interpretability and capture new insights. We employed machine learning (ML) to derive and validate a predictive model for LGF among children enrolled with diarrhea in the Vaccine Impact on Diarrhea in Africa (VIDA) study and the Enterics for Global Heath (EFGH) - Shigella study in rural western Kenya. METHODS: We used 7 diverse ML algorithms to retrospectively build prognostic models for the prediction of LGF (>/= 0.5 decrease in height/length for age z-score [HAZ]) among children 6-35 months. We used de-identified data from the VIDA study (n = 1,106) combined with synthetic data (n = 8,894) in model development, which entailed split-sampling and K-fold cross-validation with over-sampling technique, and data from EFGH-Shigella study (n = 655) for temporal validation. Potential predictors (n = 65) included demographic, household-level characteristics, illness history, anthropometric and clinical data were identified using boruta feature selection with an explanatory model analysis used to enhance interpretability. RESULTS: The prevalence of LGF in the development and temporal validation cohorts was 187 (16.9%) and 147 (22.4%), respectively. Feature selection identified the following 6 variables used in model development, ranked by importance: age (16.6%), temperature (6.0%), respiratory rate (4.1%), SAM (3.4%), rotavirus vaccination (3.3%), and skin turgor (2.1%). While all models showed good prediction capability, the gradient boosting model achieved the best performance (area under the curve % [95% Confidence Interval]: 83.5 [81.6-85.4] and 65.6 [60.8-70.4]) on the development and temporal validation datasets, respectively. CONCLUSION: Our findings accentuate the enduring relevance of established predictors of LGF whilst demonstrating the practical utility of ML algorithms for rapid identification of at-risk children. CI - (c) 2024. The Author(s). FAU - Ogwel, Billy AU - Ogwel B AD - Kenya Medical Research Institute- Center for Global Health Research (KEMRI-CGHR), P.O Box 1578-40100, Kisumu, Kenya. ogwelbill@gmail.com. AD - Department of Information Systems, University of South Africa, Pretoria, South Africa. ogwelbill@gmail.com. FAU - Mzazi, Vincent H AU - Mzazi VH AD - Department of Information Systems, University of South Africa, Pretoria, South Africa. FAU - Awuor, Alex O AU - Awuor AO AD - Kenya Medical Research Institute- Center for Global Health Research (KEMRI-CGHR), P.O Box 1578-40100, Kisumu, Kenya. FAU - Okonji, Caleb AU - Okonji C AD - Kenya Medical Research Institute- Center for Global Health Research (KEMRI-CGHR), P.O Box 1578-40100, Kisumu, Kenya. FAU - Anyango, Raphael O AU - Anyango RO AD - Kenya Medical Research Institute- Center for Global Health Research (KEMRI-CGHR), P.O Box 1578-40100, Kisumu, Kenya. FAU - Oreso, Caren AU - Oreso C AD - Kenya Medical Research Institute- Center for Global Health Research (KEMRI-CGHR), P.O Box 1578-40100, Kisumu, Kenya. FAU - Ochieng, John B AU - Ochieng JB AD - Kenya Medical Research Institute- Center for Global Health Research (KEMRI-CGHR), P.O Box 1578-40100, Kisumu, Kenya. FAU - Munga, Stephen AU - Munga S AD - Kenya Medical Research Institute- Center for Global Health Research (KEMRI-CGHR), P.O Box 1578-40100, Kisumu, Kenya. FAU - Nasrin, Dilruba AU - Nasrin D AD - Department of Medicine, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA. FAU - Tickell, Kirkby D AU - Tickell KD AD - Department of Global Health, University of Washington, Seattle, USA. FAU - Pavlinac, Patricia B AU - Pavlinac PB AD - Department of Global Health, University of Washington, Seattle, USA. FAU - Kotloff, Karen L AU - Kotloff KL AD - Department of Medicine, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA. FAU - Omore, Richard AU - Omore R AD - Kenya Medical Research Institute- Center for Global Health Research (KEMRI-CGHR), P.O Box 1578-40100, Kisumu, Kenya. LA - eng GR - EFGH Rising star(grant INV-045988)/Bill and Melinda Gates Foundation/ GR - EFGH Rising star(grant INV-045988)/Bill and Melinda Gates Foundation/ GR - EFGH Rising star(grant INV-045988)/Bill and Melinda Gates Foundation/ GR - EFGH Rising star(grant INV-045988)/Bill and Melinda Gates Foundation/ GR - EFGH Rising star(grant INV-045988)/Bill and Melinda Gates Foundation/ GR - EFGH Rising star(grant INV-045988)/Bill and Melinda Gates Foundation/ GR - EFGH Rising star(grant INV-045988)/Bill and Melinda Gates Foundation/ GR - EFGH Rising star(grant INV-045988)/Bill and Melinda Gates Foundation/ GR - EFGH Rising star(grant INV-045988)/Bill and Melinda Gates Foundation/ GR - EFGH Rising star(grant INV-045988)/Bill and Melinda Gates Foundation/ GR - EFGH Rising star(grant INV-045988)/Bill and Melinda Gates Foundation/ GR - EFGH Rising star(grant INV-045988)/Bill and Melinda Gates Foundation/ PT - Journal Article DEP - 20241202 PL - England TA - BMC Med Inform Decis Mak JT - BMC medical informatics and decision making JID - 101088682 SB - IM MH - Humans MH - Kenya/epidemiology MH - *Machine Learning MH - *Diarrhea/epidemiology MH - Infant MH - Child, Preschool MH - *Growth Disorders/epidemiology MH - Male MH - *Rural Population/statistics & numerical data MH - Female MH - Retrospective Studies MH - Models, Statistical PMC - PMC11613762 OTO - NOTNLM OT - Diarrhea OT - Linear growth faltering OT - Machine learning OT - Pediatric OT - Prediction COIS- Declarations. Ethics approval and consent to participate: The VIDA protocol was approved by the Institutional Review Board of the University of Maryland School of Medicine, Baltimore, MD, USA (UMB Protocol #: HM-HP-00062472) and the Kenya Medical Research Institute (KEMRI) Scientific and Ethical Review Unit (SERU) (SERU#2996). The EFGH protocol was approved by the KEMRI SERU (SERU#4362). Written informed consent was sought from caregivers in both studies before initiation of study procedures. Additionally, ethical approval for undertaking the current study was sought from the health research ethics committee of the University of South Africa, College of Agricultural Sciences (2023/CAES_HREC/2192). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2024/12/03 00:23 MHDA- 2024/12/03 06:24 PMCR- 2024/12/02 CRDT- 2024/12/02 23:52 PHST- 2024/03/08 00:00 [received] PHST- 2024/11/22 00:00 [accepted] PHST- 2024/12/03 06:24 [medline] PHST- 2024/12/03 00:23 [pubmed] PHST- 2024/12/02 23:52 [entrez] PHST- 2024/12/02 00:00 [pmc-release] AID - 10.1186/s12911-024-02779-7 [pii] AID - 2779 [pii] AID - 10.1186/s12911-024-02779-7 [doi] PST - epublish SO - BMC Med Inform Decis Mak. 2024 Dec 2;24(1):368. doi: 10.1186/s12911-024-02779-7. PMID- 39621946 OWN - NLM STAT- MEDLINE DCOM- 20241202 LR - 20260518 IS - 1526-632X (Electronic) IS - 0028-3878 (Print) IS - 0028-3878 (Linking) VI - 103 IP - 12 DP - 2024 Dec 24 TI - Patient-Relevant Digital-Motor Outcomes for Clinical Trials in Hereditary Spastic Paraplegia Type 7: A Multicenter PROSPAX Study. PG - e209887 LID - 10.1212/WNL.0000000000209887 [doi] LID - e209887 AB - BACKGROUND AND OBJECTIVES: With targeted treatment trials on the horizon, identification of sensitive and valid outcome measures becomes a priority for >100 spastic ataxias. While digital-motor measures, assessed using wearable sensors, are considered prime outcome candidates for spastic ataxias, genotype-specific validation studies are lacking. We here aimed to identify candidate digital-motor outcomes for spastic paraplegia type 7 (SPG7)-one of the most common spastic ataxias-that (1) reflect patient-relevant health aspects, even in mild, trial-relevant disease stages; (2) are suitable for a multicenter setting; and (3) assess mobility also during uninstructed walking simulating real life. METHODS: This cross-sectional multicenter study (7 centers, 6 countries) analyzed defined laboratory-based walking and uninstructed "supervised free walking" in patients with SPG7 and healthy controls using 3 wearable sensors (Opal APDM). For the extracted digital gait measures, we assessed effect sizes for the discrimination of patients and controls (Cliff delta) and Spearman correlations with measures of functional mobility and overall disease severity (Spastic Paraplegia Rating Scale [SPRS], including mobility subscore SPRS(mobility); Scale for the Assessment and Rating of Ataxia [SARA]) and the activities of daily living subscore of the Friedreich Ataxia Rating Scale (FARS-ADL). RESULTS: Gait was analyzed in 65 patients with SPG7 and 50 healthy controls. Among 30 hypothesis-based gait measures, 18 demonstrated at least moderate effect size (delta > 0.5) in discriminating patients from controls and 17 even in mild disease stages (SPRS(mobility) 77%) was found. However, in both countries, both modules underestimate the mean energy intake coming from foods consumed away from home (from 122 to 408 kcal) while they overestimate the budget allocated to it (from -0.07 to -0.29 USD/day). None of developed food away from home modules were considered as valid. There is a need for the international community to continue to work on developing and validating tools capable to estimate nutritional intakes related to food consumption away from home and that could be added to regular national household-level surveys. CI - Copyright: (c) 2024 Landais et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Landais, Edwige AU - Landais E AUID- ORCID: 0000-0002-7291-2012 AD - MoISA, Univ Montpellier, CIRAD, CIHEAM-IAMM, INRAE, Institut Agro, IRD, Montpellier, France. FAU - Pelloquin, Raphael AU - Pelloquin R AD - MoISA, Univ Montpellier, CIRAD, CIHEAM-IAMM, INRAE, Institut Agro, IRD, Montpellier, France. FAU - Maitre d'Hotel, Elodie AU - Maitre d'Hotel E AD - MoISA, Univ Montpellier, CIRAD, CIHEAM-IAMM, INRAE, Institut Agro, IRD, Montpellier, France. FAU - Truong Tuyet, Mai AU - Truong Tuyet M AUID- ORCID: 0000-0002-5115-8655 AD - National Institute of Nutrition, Nutrition-Network Department, Hanoi, Vietnam. FAU - Hoang Thu, Nga AU - Hoang Thu N AD - National Institute of Nutrition, Nutrition-Network Department, Hanoi, Vietnam. FAU - Bui Thi Thao, Yen AU - Bui Thi Thao Y AD - National Institute of Nutrition, Nutrition-Network Department, Hanoi, Vietnam. FAU - Do Thi Phuong, Ha AU - Do Thi Phuong H AD - National Institute of Nutrition, Nutrition-Network Department, Hanoi, Vietnam. FAU - Thu, Trang Tran Thi AU - Thu TTT AD - National Institute of Nutrition, Nutrition-Network Department, Hanoi, Vietnam. FAU - Some, Jerome AU - Some J AD - Departement Biomedical et Sante Publique, Institut de Recherche en Sciences de la Sante, Centre National de la Recherche Scientifique et Technologie, Ouagadougou, Burkina Faso. FAU - Bene, Christophe AU - Bene C AUID- ORCID: 0000-0002-7078-9241 AD - Food Environment and Consumer Behaviour Department, Alliance Bioversity International-CIAT, Cali, Colombia. FAU - Verger, Eric O AU - Verger EO AUID- ORCID: 0000-0002-8689-8290 AD - MoISA, Univ Montpellier, CIRAD, CIHEAM-IAMM, INRAE, Institut Agro, IRD, Montpellier, France. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241202 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Burkina Faso MH - Vietnam MH - Humans MH - Female MH - *Family Characteristics MH - Male MH - Adult MH - Middle Aged MH - Diet Surveys MH - Feeding Behavior MH - Developing Countries MH - Diet MH - Young Adult MH - Adolescent MH - Nutritional Status MH - Eating MH - Energy Intake PMC - PMC11611215 COIS- The authors have declared that no competing interests exist. EDAT- 2024/12/02 18:27 MHDA- 2024/12/02 18:28 PMCR- 2024/12/02 CRDT- 2024/12/02 13:55 PHST- 2024/07/01 00:00 [received] PHST- 2024/11/15 00:00 [accepted] PHST- 2024/12/02 18:28 [medline] PHST- 2024/12/02 18:27 [pubmed] PHST- 2024/12/02 13:55 [entrez] PHST- 2024/12/02 00:00 [pmc-release] AID - PONE-D-24-21954 [pii] AID - 10.1371/journal.pone.0314786 [doi] PST - epublish SO - PLoS One. 2024 Dec 2;19(12):e0314786. doi: 10.1371/journal.pone.0314786. eCollection 2024. PMID- 39621377 OWN - NLM STAT- MEDLINE DCOM- 20250109 LR - 20250925 IS - 1939-134X (Electronic) IS - 1040-3590 (Linking) VI - 37 IP - 1-2 DP - 2025 Jan-Feb TI - Measuring eating behavior and motivations in the United Arab Emirates and the United States: Evaluating measurement and predictive invariance of the Eating Disorder Examination Questionnaire-Short Form and the Eating Motivation Survey. PG - 62-69 LID - 10.1037/pas0001352 [doi] AB - Considerable proportions of college students in White, educated, industrialized, rich, and democratic countries, such as the United States, suffer from eating disorders and other problematic eating behaviors. The prevalence of eating disorders in Western Asia has been historically low but is rapidly increasing. One of the most dramatic increases is occurring in the United Arab Emirates. Advancements in eating disorder research and intervention that would benefit college students in the United Arab Emirates are inhibited by the lack of psychometrically sound measures of eating behaviors and motivations that have been empirically demonstrated to perform well in this population. The present study took initial steps in filling this need by evaluating the measurement and predictive invariance of the Eating Disorder Examination Questionnaire-Short Form and The Eating Motivation Survey using college student samples from the United Arab Emirates (n = 366) and United States (n = 317), followed by a series of cross-country comparisons. Results offer important evidence supporting the measurement invariance of both instruments and the predictive invariance of the The Eating Motivation Survey when used to predict scores on the Eating Disorder Examination Questionnaire-Short Form. Although no significant cross-country differences in eating disorder features and behaviors were found, some cross-country differences in eating motivations were observed. Similar eating motivations emerged in both countries as possible protective and risk factors for eating disorders. The implications of these findings for eating disorder assessment and practice are discussed, along with their implications for theory and research on eating motivations, nutritional health, and people's relationships with food. (PsycInfo Database Record (c) 2025 APA, all rights reserved). FAU - Natoli, Adam P AU - Natoli AP AUID- ORCID: 0000-0002-2324-9242 AD - Department of Psychology and Philosophy, Sam Houston State University. FAU - Allen, Lauren K AU - Allen LK AUID- ORCID: 0000-0002-1692-2582 AD - Department of Psychology and Philosophy, Sam Houston State University. FAU - Ashton, Caitlyn M AU - Ashton CM AUID- ORCID: 0009-0006-4479-5249 AD - Department of Human Sciences, Sam Houston State University. FAU - Lamba, Nishtha AU - Lamba N AD - Department of Psychology, Middlesex University Dubai. FAU - Marek, Ryan J AU - Marek RJ AUID- ORCID: 0000-0002-5658-0951 AD - Department of Psychology and Philosophy, Sam Houston State University. LA - eng PT - Journal Article DEP - 20241202 PL - United States TA - Psychol Assess JT - Psychological assessment JID - 8915253 SB - IM MH - Humans MH - United Arab Emirates/epidemiology MH - Female MH - *Feeding and Eating Disorders/psychology/diagnosis/epidemiology MH - United States MH - *Motivation MH - Young Adult MH - Male MH - *Feeding Behavior/psychology MH - Surveys and Questionnaires MH - Adolescent MH - *Psychometrics MH - Adult MH - Students/psychology MH - Cross-Cultural Comparison MH - Reproducibility of Results EDAT- 2024/12/02 12:32 MHDA- 2025/01/09 18:21 CRDT- 2024/12/02 11:53 PHST- 2025/01/09 18:21 [medline] PHST- 2024/12/02 12:32 [pubmed] PHST- 2024/12/02 11:53 [entrez] AID - 2025-50547-001 [pii] AID - 10.1037/pas0001352 [doi] PST - ppublish SO - Psychol Assess. 2025 Jan-Feb;37(1-2):62-69. doi: 10.1037/pas0001352. Epub 2024 Dec 2. PMID- 39616982 OWN - NLM STAT- MEDLINE DCOM- 20250426 LR - 20250728 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 131 DP - 2025 Mar TI - Unlocking insights: Using machine learning to identify wasting and risk factors in Egyptian children under 5. PG - 112631 LID - S0899-9007(24)00280-6 [pii] LID - 10.1016/j.nut.2024.112631 [doi] AB - INTRODUCTION: Malnutrition, particularly wasting, continues to be a significant public health issue among children under five years in Egypt. Despite global advancements in child health, the prevalence of wasting remains a critical concern. This study employs machine learning techniques to identify and analyze the determinants of wasting in this population. AIM: To evaluate the prevalence of wasting among children under five years in Egypt and identify key factors associated with wasting using machine learning models. METHODS: This study is based on secondary data sourced from the Demographic and Health Surveys (DHS), conducted in 2005, 2008, and 2014. Six machine learning classifiers (XGBoost, Logistic Regression, Random Forest, Gradient Boosting, K-Nearest Neighbor, and Decision Tree) were applied to the dataset. The study included children under five years of age, focusing on nutritional status, maternal health, and socio-economic factors. The dataset was cleaned, preprocessed, encoded using one-hot encoding, and split into training (70%) and test (30%) sets. Additionally, k-fold cross-validation and the StandardScaler function from Scikit-learn were used. Performance metrics such as accuracy, precision, recall, F1 score, and ROC-AUC were used to evaluate and compare the algorithms. RESULTS: It was observed that 76.2% of the children in the dataset have normal nutritional status. Furthermore, 5.2% were found to be suffering from wasting (1.7% experiencing severe wasting and 3.5% moderate wasting), with notable regional disparities. The XGBoost model outperformed other models. Its efficiency metrics include an accuracy of 94.8%, precision of 94.7%, recall of 94.7%, F1 score of 94.7%, and an ROC-AUC of 99.4%. These results indicate that XGBoost was highly effective in predicting wasting. CONCLUSION: Machine learning techniques, particularly XGBoost, show significant potential for improving the classification of nutritional status and addressing wasting among children in Egypt. However, the limitations in simpler models highlight the need for further research to refine predictive tools and develop targeted interventions. Addressing the identified determinants of wasting can contribute to more effective public health strategies. CI - Copyright (c) 2024 Elsevier Inc. All rights reserved. FAU - Hendy, Abdelaziz AU - Hendy A AD - Pediatric Nursing Department, Faculty Nursing, Ain Shams University, Cairo, Egypt. Electronic address: Abdelaziz.hendy@nursing.asu.edu.eg. FAU - Abdelaliem, Sally Mohammed Farghaly AU - Abdelaliem SMF AD - Department of Nursing Management and Education, College of Nursing, Princess Nourah bint Abdulrahman University, P.O.Box 84428, Riyadh 11671, Saudi Arabia. Electronic address: smfarghaly@pnu.edu.sa. FAU - Sultan, Hosny Maher AU - Sultan HM AD - College of Nursing, Gulf Medical University, Ajman, UAE. Electronic address: dr.hosny@gmu.ac.ae. FAU - Alahmedi, Shorok Hamed AU - Alahmedi SH AD - Department of Nursing Management and Education, College of Nursing, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. Electronic address: shalahmedi@pnu.edu.sa. FAU - Ibrahim, Rasha Kadri AU - Ibrahim RK AD - Nursing Department, Fatima College of Health Sciences, Madinat Zayed, UAE. Electronic address: rasha.ibrahim@actvet.gov.ae. FAU - Abdelrazek, Eman Mohamed Ebrahim AU - Abdelrazek EME AD - Community Health Nursing Department, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia. Electronic address: eabdelrazek@jazanu.edu.sa. FAU - Elmahdy, Masani Abdelbagi Ahmed AU - Elmahdy MAA AD - College of Nursing, Gulf Medical University, Ajman, UAE. Electronic address: Masani.elmahdy@gmail.com. FAU - Hendy, Ahmed AU - Hendy A AD - Department of Computational Mathematics and Computer Science, Institute of Natural Sciences and Mathematics, Ural Federal University, Yekaterinburg, Russian Federation; Department of Mechanics and Mathematics, Western Caspian University, Baku, Azerbaijan; Department of Mathematics and Computer science, Faculty of Science, Benha University, Benha, Egypt. Electronic address: ahmed.hendy@fsc.bu.edu.eg. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241112 PL - United States TA - Nutrition JT - Nutrition (Burbank, Los Angeles County, Calif.) JID - 8802712 SB - IM MH - Humans MH - *Machine Learning MH - Egypt/epidemiology MH - *Wasting Syndrome/epidemiology/diagnosis/etiology MH - Female MH - Child, Preschool MH - Infant MH - Risk Factors MH - Male MH - Prevalence MH - Nutritional Status MH - Socioeconomic Factors MH - Logistic Models MH - Health Surveys OTO - NOTNLM OT - Child nutrition OT - Egypt OT - Machine learning OT - Public health OT - Wasting OT - Weight-for-height Z-scores COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/12/02 05:30 MHDA- 2025/02/23 00:42 CRDT- 2024/12/01 18:10 PHST- 2024/08/30 00:00 [received] PHST- 2024/10/21 00:00 [revised] PHST- 2024/10/25 00:00 [accepted] PHST- 2025/02/23 00:42 [medline] PHST- 2024/12/02 05:30 [pubmed] PHST- 2024/12/01 18:10 [entrez] AID - S0899-9007(24)00280-6 [pii] AID - 10.1016/j.nut.2024.112631 [doi] PST - ppublish SO - Nutrition. 2025 Mar;131:112631. doi: 10.1016/j.nut.2024.112631. Epub 2024 Nov 12. PMID- 39616356 OWN - NLM STAT- MEDLINE DCOM- 20241130 LR - 20241203 IS - 1471-2474 (Electronic) IS - 1471-2474 (Linking) VI - 25 IP - 1 DP - 2024 Nov 30 TI - Network analyses of physical and psychological factors of playing-related musculoskeletal disorders in student musicians: a cross-sectional study. PG - 979 LID - 10.1186/s12891-024-08103-8 [doi] LID - 979 AB - BACKGROUND: Young musicians starting their professional education are particularly vulnerable to playing-related musculoskeletal disorders (PRMDs). In the context of research on PRMDs, physical and psychological associated factors are frequently highlighted without investigating their complex interrelationships. The objective of this exploratory study was to examine the associations between lifestyle, music practice habits, physical and psychological variables, and PRMDs in student musicians. METHODS: Students of the Geneva University of Music participated in the survey. The primary outcome was students' PRMDs, measured with the validated Musculoskeletal Pain Intensity and Interference Questionnaire for Musicians (MPIIQM). Additionally, to investigate potential associated factors, participants completed free-form questions about lifestyle and practice habits and seven validated questionnaires: physical activity, self-rated health, psychological distress, musical performance anxiety (MPA), perfectionism, fatigue, and personality traits. After performing standard descriptive statistics, network analyses were applied to investigate the links between students' PRMDs experience and all factors. RESULTS: Two hundred thirty-five student musicians completed the survey. 86 (37%) participants experienced PRMDs over the last 12 months. When considering all participating students, the network analysis showed the strongest association between the presence of PRMDs and the psychological distress factor. In the subgroup with students with PRMDs, the degree of pain interference with musical practice was correlated with psychological distress, MPA, self-rated health, and fatigue. CONCLUSION: Psychological distress is the primary factor associated with PRMDs, whereas physical factors like posture and activity show no direct link. Therefore, addressing psychological aspects is crucial for student musicians with physical disorders to provide proper prevention care. CI - (c) 2024. The Author(s). FAU - Bruyneel, Anne-Violette AU - Bruyneel AV AUID- ORCID: 0000-0003-4764-9336 AD - Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western, Geneva, Switzerland. Anne-violette.bruyneel@hesge.ch. FAU - Stern, Florian AU - Stern F AD - Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western, Geneva, Switzerland. FAU - Schmid, Audrey AU - Schmid A AD - Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western, Geneva, Switzerland. FAU - Rieben, Nancy AU - Rieben N AD - Geneva University of Music, HES-SO University of Applied Sciences and Arts Western, Geneva, Switzerland. FAU - James, Clara E AU - James CE AD - Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western, Geneva, Switzerland. AD - Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland. LA - eng GR - 05-S22/Haute ecole Specialisee de Suisse Occidentale/ GR - 05-S22/Haute ecole Specialisee de Suisse Occidentale/ GR - 05-S22/Haute ecole Specialisee de Suisse Occidentale/ GR - 05-S22/Haute ecole Specialisee de Suisse Occidentale/ PT - Journal Article DEP - 20241130 PL - England TA - BMC Musculoskelet Disord JT - BMC musculoskeletal disorders JID - 100968565 SB - IM MH - Humans MH - *Music MH - Female MH - Male MH - Cross-Sectional Studies MH - *Students/psychology MH - Young Adult MH - *Occupational Diseases/epidemiology/psychology/etiology MH - *Musculoskeletal Diseases/epidemiology/psychology/diagnosis MH - Adult MH - Surveys and Questionnaires MH - Adolescent MH - Performance Anxiety/psychology/epidemiology MH - Musculoskeletal Pain/psychology/epidemiology/diagnosis/etiology MH - Risk Factors MH - Exercise/psychology MH - Life Style PMC - PMC11607880 OTO - NOTNLM OT - Network analysis OT - Physical and psychological factors OT - Playing-related musculoskeletal disorders OT - Student musicians COIS- Declarations. Ethics approval and consent to participate: The full protocol was approved by the Swiss Ethics Committee "Commission cantonale d'ethique de la recherche sur l'etre humain de Geneve" (CCER, no. 2022-02206) on 13.02.2023, in accordance with the Declaration of Helsinki. After an information, written informed consent was obtained from all participants. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. EDAT- 2024/12/01 15:22 MHDA- 2024/12/01 15:23 PMCR- 2024/11/30 CRDT- 2024/11/30 23:38 PHST- 2024/09/07 00:00 [received] PHST- 2024/11/21 00:00 [accepted] PHST- 2024/12/01 15:23 [medline] PHST- 2024/12/01 15:22 [pubmed] PHST- 2024/11/30 23:38 [entrez] PHST- 2024/11/30 00:00 [pmc-release] AID - 10.1186/s12891-024-08103-8 [pii] AID - 8103 [pii] AID - 10.1186/s12891-024-08103-8 [doi] PST - epublish SO - BMC Musculoskelet Disord. 2024 Nov 30;25(1):979. doi: 10.1186/s12891-024-08103-8. PMID- 39616199 OWN - NLM STAT- MEDLINE DCOM- 20241130 LR - 20260311 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Nov 30 TI - Validation studies of the FLASH-TV system to passively measure children's TV viewing. PG - 29805 LID - 10.1038/s41598-024-81136-0 [doi] LID - 29805 AB - TV viewing is associated with health risks, but existing measures of TV viewing are imprecise due to relying on self-report. We developed the Family Level Assessment of Screen use in the Home (FLASH)-TV, a machine learning pipeline with state-of-the-art computer vision methods to measure children's TV viewing. In three studies, lab pilot (n = 10), lab validation (n = 30), and home validation (n = 20), we tested the validity of FLASH-TV 3.0 in task-based protocols which included video observations of children for 60 min. To establish a gold-standard to compare FLASH-TV output, the videos were labeled by trained staff at 5-second epochs for whenever the child watched TV. For the combined sample with valid data (n = 59), FLASH-TV 3.0 provided a mean 85% (SD 8%) accuracy, 80% (SD 17%) sensitivity, 86% (SD 8%) specificity, and 0.71 (SD 0.15) kappa, compared to gold-standard. The mean intra-class correlation (ICC) of child's TV viewing durations of FLASH-TV 3.0 to gold-standard was 0.86. Overall, FLASH-TV 3.0 correlated well with the gold standard across a diverse sample of children, but with higher variability among Black children than others. FLASH-TV provides a tool to estimate children's TV viewing and increase the precision of research on TV viewing's impact on children's health. CI - (c) 2024. The Author(s). FAU - Vadathya, Anil Kumar AU - Vadathya AK AD - Department of Electrical & Computer Engineering, Rice University, Houston, TX, USA. FAU - Garza, Tatyana AU - Garza T AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. FAU - Alam, Uzair AU - Alam U AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. FAU - Ho, Alex AU - Ho A AD - Rice University, Houston, TX, USA. FAU - Musaad, Salma M A AU - Musaad SMA AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. FAU - Beltran, Alicia AU - Beltran A AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. FAU - Moreno, Jennette P AU - Moreno JP AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. FAU - Baranowski, Tom AU - Baranowski T AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. FAU - Haidar, Nimah AU - Haidar N AD - Rice University, Houston, TX, USA. FAU - Hughes, Sheryl O AU - Hughes SO AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. FAU - Mendoza, Jason A AU - Mendoza JA AD - Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. AD - General Pediatrics, Department of Pediatrics, University of Washington, Seattle, WA, USA. FAU - Veeraraghavan, Ashok AU - Veeraraghavan A AD - Department of Electrical & Computer Engineering, Rice University, Houston, TX, USA. FAU - Young, Joseph AU - Young J AD - Department of Electrical & Computer Engineering, Rice University, Houston, TX, USA. FAU - Sano, Akane AU - Sano A AD - Department of Electrical & Computer Engineering, Rice University, Houston, TX, USA. FAU - O'Connor, Teresia M AU - O'Connor TM AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. teresiao@bcm.edu. LA - eng GR - P01 HD109876/HD/NICHD NIH HHS/United States GR - R01 DK113269/DK/NIDDK NIH HHS/United States GR - P01HD109876/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ GR - R01DK113269/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH)/ PT - Journal Article PT - Validation Study DEP - 20241130 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Television MH - Female MH - Male MH - Child MH - Screen Time MH - Machine Learning MH - Child, Preschool PMC - PMC11608350 OTO - NOTNLM OT - Face detection OT - Gaze estimation OT - Machine learning OT - Screen media OT - Television COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2024/12/01 15:22 MHDA- 2024/12/01 15:23 PMCR- 2024/11/30 CRDT- 2024/11/30 23:18 PHST- 2024/05/17 00:00 [received] PHST- 2024/11/25 00:00 [accepted] PHST- 2024/12/01 15:23 [medline] PHST- 2024/12/01 15:22 [pubmed] PHST- 2024/11/30 23:18 [entrez] PHST- 2024/11/30 00:00 [pmc-release] AID - 10.1038/s41598-024-81136-0 [pii] AID - 81136 [pii] AID - 10.1038/s41598-024-81136-0 [doi] PST - epublish SO - Sci Rep. 2024 Nov 30;14(1):29805. doi: 10.1038/s41598-024-81136-0. PMID- 39615129 OWN - NLM STAT- MEDLINE DCOM- 20250131 LR - 20250517 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 80 DP - 2025 Jan-Feb TI - Comparison of nutritional screening tools in pediatric oncology patients receiving chemotherapy treatment. PG - 154-160 LID - S0882-5963(24)00424-X [pii] LID - 10.1016/j.pedn.2024.11.009 [doi] AB - BACKGROUND: Malnutrition in pediatric oncology patients is a complex and multifactorial process, and the most appropriate screening tool to determine the risk of malnutrition is not clear. The study aimed to compare the Screening Tool for Risk on Nutritional Status and Growth (StrongKids), Pediatric Yorkhill Malnutrition Score (PYMS), Screening Tool for the Assessment of Malnutrition in Pediatrics (STAMP), which are commonly used in the general pediatric population, with the Nutrition Screening Tool for Childhood Cancer (SCAN), which was specifically validated for pediatric cancer, in determining the risk of malnutrition. METHODS: This cross-sectional study included 92 children aged 2-18 years who were admitted to the hematology-oncology unit and were receiving chemotherapy. The prevalence of nutritional risk was determined using the SCAN, StrongKids, PYMS, STAMP, and anthropometric assessments were performed. Sensitivity and specificity values, and the degree of agreement between screening tools were calculated. RESULT: The SCAN identified nutritional risk in 69.6 % of the children. According to StrongKids, PYMS and STAMP, the high nutritional risk in children was 43.5 %, 56.5 % and 64.1 %, respectively. The sensitivity of STAMP (81.2 %) was higher than that of StrongKids (60.9 %) and PYMS (79.7 %). The specificity of StrongKids, PYMS and STAMP was 96.4 %, 96.4 %, and 75.0 %, respectively. There was substantial agreement between SCAN and PYMS. CONCLUSION: PYMS has the best specificity and sensitivity in identifying patients at risk of malnutrition as determined by SCAN. IMPLICATIONS FOR PRACTICE: In addition to anthropometric measurements, population-specific or highly sensitive nutritional screening tools should be used to determine the risk of malnutrition. CI - Copyright (c) 2024 Elsevier Inc. All rights reserved. FAU - Meral, Buket AU - Meral B AD - Department of Child Health and Diseases Nursing, Faculty of Health Sciences, Karadeniz Technical University, Trabzon, Turkey. Electronic address: buketguvenir@hotmail.com. FAU - Kangalgil, Melda AU - Kangalgil M AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Sivas Cumhuriyet University, Sivas, Turkey. Electronic address: meldakangalgil@cumhuriyet.edu.tr. FAU - Erduran, Erol AU - Erduran E AD - Department of Pediatric Hematology and Oncology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey. Electronic address: erduran@ktu.edu.tr. LA - eng PT - Comparative Study PT - Journal Article DEP - 20241129 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 RN - 0 (Antineoplastic Agents) SB - IM MH - Humans MH - Child MH - Cross-Sectional Studies MH - Male MH - Female MH - Child, Preschool MH - *Nutrition Assessment MH - *Neoplasms/drug therapy/complications MH - Adolescent MH - *Malnutrition/diagnosis/epidemiology MH - Nutritional Status MH - *Mass Screening/methods MH - *Antineoplastic Agents/adverse effects/therapeutic use MH - Risk Assessment MH - Sensitivity and Specificity OTO - NOTNLM OT - Chemotherapy OT - Child nutrition disorders OT - Malnutrition OT - Malnutrition in children OT - Nurses OT - Nutrition assessment OT - Nutritional status COIS- Declaration of competing interest The authors have no conflicts of interest to declare. EDAT- 2024/12/01 15:22 MHDA- 2025/02/01 20:41 CRDT- 2024/11/30 18:04 PHST- 2024/07/22 00:00 [received] PHST- 2024/11/13 00:00 [revised] PHST- 2024/11/13 00:00 [accepted] PHST- 2025/02/01 20:41 [medline] PHST- 2024/12/01 15:22 [pubmed] PHST- 2024/11/30 18:04 [entrez] AID - S0882-5963(24)00424-X [pii] AID - 10.1016/j.pedn.2024.11.009 [doi] PST - ppublish SO - J Pediatr Nurs. 2025 Jan-Feb;80:154-160. doi: 10.1016/j.pedn.2024.11.009. Epub 2024 Nov 29. PMID- 39614888 OWN - NLM STAT- MEDLINE DCOM- 20241130 LR - 20250218 IS - 1436-6215 (Electronic) IS - 1436-6207 (Print) IS - 1436-6207 (Linking) VI - 64 IP - 1 DP - 2024 Nov 30 TI - Frequent intake of high fiber and probiotic diets lowers risks associated with atopic dermatitis and house dust mite allergy: a cross-sequential study of young Chinese adults from Singapore and Malaysia. PG - 38 LID - 10.1007/s00394-024-03524-6 [doi] LID - 38 AB - PURPOSE: Dietary fiber intake may influence the risk and severity of atopic dermatitis (AD), a common chronic allergic skin condition. This cross-sequential study investigated the association between dietary fiber intake and various characteristics of AD, including house dust mites (HDM) allergy and dry skin, in 13,561 young Chinese adults (mean years = 22.51, SD +/- 5.90) from Singapore and Malaysia. METHODS: Dietary habits were assessed using a validated semi-quantitative, investigator-administered food frequency questionnaire from the International Study of Asthma and Allergies in Childhood. We derived an amount-based dietary index to estimate fiber intake while studying its correlation with probiotic drinks intake. AD status was determined by skin prick tests for HDM and symptomatic histories of eczema. Multivariable logistic regression analysis, adjusting for demographic, genetic predisposition, body mass index and lifestyle factors, and synergy factor analysis were used to explore the association and interaction of dietary factors on disease outcomes. RESULTS: High fiber intake (approximately 98.25 g/serving/week) significantly lowered the associated risks for HDM allergy (Adjusted Odds Ratio [AOR]: 0.895; 95% Confidence Intervals [CI]: 0.810-0.989; adjusted p-value < 0.05) and AD (AOR: 0.831; 95% CI: 0.717-0.963; adjusted p-value < 0.05), but not dry skin. While probiotic intake was not associated with AD, it was significantly correlated with fiber intake (R(2) = 0.324, p-value < 0.0001). Among those frequently consuming probiotics, moderate fiber intake sufficiently lowered the AD risk (AOR: 0.717; 95% CI: 0.584-0.881; adjusted p-value < 0.01). Moreover, a fibre-rich diet independently mitigated risks associated with high intake of fats, saturated fats, and protein. CONCLUSION: A high-fiber diet is associated with AD and HDM allergy. Moderate-to-high fiber intake, particularly in conjunction with probiotics, may further mitigate AD risks. CI - (c) 2024. The Author(s). FAU - Lim, Jun Jie AU - Lim JJ AD - Department of Biological Sciences, Faculty of Science, National University of Singapore, Allergy and Molecular Immunology Laboratory, Lee Hiok Kwee Functional Genomics Laboratories, Block S2, Level 5, 14 Science Drive 4, off Lower Kent Ridge Road, Singapore, 117543, Singapore. FAU - Reginald, Kavita AU - Reginald K AD - Department of Biological Sciences, Faculty of Science, National University of Singapore, Allergy and Molecular Immunology Laboratory, Lee Hiok Kwee Functional Genomics Laboratories, Block S2, Level 5, 14 Science Drive 4, off Lower Kent Ridge Road, Singapore, 117543, Singapore. AD - Department of Biological Sciences, School of Medicine and Life Sciences, Sunway University, 47500, Petaling Jaya, Selangor, Malaysia. FAU - Say, Yee-How AU - Say YH AD - Department of Biological Sciences, Faculty of Science, National University of Singapore, Allergy and Molecular Immunology Laboratory, Lee Hiok Kwee Functional Genomics Laboratories, Block S2, Level 5, 14 Science Drive 4, off Lower Kent Ridge Road, Singapore, 117543, Singapore. AD - Department of Biological Sciences, School of Medicine and Life Sciences, Sunway University, 47500, Petaling Jaya, Selangor, Malaysia. AD - Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman (UTAR), 31900, Kampar, Perak, Malaysia. FAU - Liu, Mei Hui AU - Liu MH AD - Department of Food Science & Technology, Faculty of Science, National University of Singapore, Singapore, 117543, Singapore. FAU - Chew, Fook Tim AU - Chew FT AUID- ORCID: 0000-0003-1337-5146 AD - Department of Biological Sciences, Faculty of Science, National University of Singapore, Allergy and Molecular Immunology Laboratory, Lee Hiok Kwee Functional Genomics Laboratories, Block S2, Level 5, 14 Science Drive 4, off Lower Kent Ridge Road, Singapore, 117543, Singapore. dbscft@nus.edu.sg. LA - eng GR - N-154-000-038-001/National University of Singapore/ GR - R-154-000-191-112/Singapore Ministry of Education Academic Research Fund/ GR - R-154-000-404-112/Singapore Ministry of Education Academic Research Fund/ GR - R-154-000-553-112/Singapore Ministry of Education Academic Research Fund/ GR - R-154-000-565-112/Singapore Ministry of Education Academic Research Fund/ GR - R-154-000-630-112/Singapore Ministry of Education Academic Research Fund/ GR - R-154-000-A08-592/Singapore Ministry of Education Academic Research Fund/ GR - R-154-000-A27-597/Singapore Ministry of Education Academic Research Fund/ GR - R-154-000-A91-592/Singapore Ministry of Education Academic Research Fund/ GR - R-154-000-A95-592/Singapore Ministry of Education Academic Research Fund/ GR - R-154-000-B99-114/Singapore Ministry of Education Academic Research Fund/ GR - SIgN-06-006/Singapore Immunology Network/ GR - SIgN-08-020/Singapore Immunology Network/ GR - NMRC/1150/2008/National Medical Research Council/ GR - OFIRG20nov-0033/National Medical Research Council/ GR - BMRC/01/1/21/18/077/Biomedical Research Council/ GR - BMRC/04/1/21/19/315/Biomedical Research Council/ GR - BMRC/APG2013/108/Biomedical Research Council/ GR - NRF-MP-2020-0004/National Research Foundation Singapore/ GR - SFS_RND_SUFP_001_04/Singapore Food Agency/ GR - W22W3D0006/Singapore Food Agency/ GR - H17/01/a0/008/Agency for Science Technology and Research (A*STAR) (Singapore)/ GR - APG2013/108/Agency for Science Technology and Research (A*STAR) (Singapore)/ PT - Journal Article DEP - 20241130 PL - Germany TA - Eur J Nutr JT - European journal of nutrition JID - 100888704 RN - 0 (Dietary Fiber) SB - IM MH - Adolescent MH - Adult MH - Animals MH - Female MH - Humans MH - Male MH - Young Adult MH - China/epidemiology MH - Cross-Sectional Studies MH - *Dermatitis, Atopic/epidemiology MH - Diet/methods MH - *Dietary Fiber/administration & dosage MH - Dust Mite Allergy MH - East Asian People MH - Hypersensitivity/epidemiology MH - Malaysia/epidemiology MH - *Probiotics/administration & dosage MH - *Pyroglyphidae/immunology MH - Risk Factors MH - Singapore/epidemiology PMC - PMC11608386 OTO - NOTNLM OT - Allergy sensitization OT - Atopic dermatitis OT - Dietary fibers OT - Epidemiology OT - Ethnic Chinese COIS- Declarations. Conflict of interest: The other authors declare no other competing interests. Ethical approval and consent: This study was conducted in accordance with the principles of the Declaration of Helsinki and Good Clinical Practices, and in compliance with local regulatory requirements. Cross-sectional studies in Singapore were conducted on the National University of Singapore (NUS) campus annually between 2005 and 2022, under the approval of the Institutional Review Board (NUS-IRB Reference Code: NUS-07-023, NUS-09-256, NUS-10-445, NUS-13-075, NUS-14-150, and NUS-18-036) and by the Helsinki declaration. Cross-sectional studies in Malaysia were held in the Universiti Tunku Abdul Rahman (UTAR), and Sunway University. Ethical approval was granted respectively from the Scientific and Ethical Review Committee (SERC) of UTAR (Ref. code: U/SERC/03/2016) and Sunway University Research Ethics Committee (Ref. code: SUREC 2019/029). Before the data collection, all participants involved signed an informed consent form. Consent for publication: All authors have read and consented to the publication of this manuscript. EDAT- 2024/12/01 15:20 MHDA- 2024/12/01 15:21 PMCR- 2024/11/30 CRDT- 2024/11/30 11:03 PHST- 2024/04/30 00:00 [received] PHST- 2024/10/18 00:00 [accepted] PHST- 2024/12/01 15:21 [medline] PHST- 2024/12/01 15:20 [pubmed] PHST- 2024/11/30 11:03 [entrez] PHST- 2024/11/30 00:00 [pmc-release] AID - 10.1007/s00394-024-03524-6 [pii] AID - 3524 [pii] AID - 10.1007/s00394-024-03524-6 [doi] PST - epublish SO - Eur J Nutr. 2024 Nov 30;64(1):38. doi: 10.1007/s00394-024-03524-6. PMID- 39614600 OWN - NLM STAT- MEDLINE DCOM- 20250716 LR - 20260810 IS - 1365-2869 (Electronic) IS - 0962-1105 (Print) IS - 0962-1105 (Linking) VI - 34 IP - 4 DP - 2025 Aug TI - Accelerometry for sleep assessment in children: Criterium validity of different algorithms in wrist- and ankle-worn devices. PG - e14426 LID - 10.1111/jsr.14426 [doi] LID - e14426 AB - Polysomnography, the gold-standard for measuring sleep, is costly, intrusive and usually limited to 1 night. Actigraphy offers a more affordable, less intrusive method over multiple nights. However, little research validates ActiGraph accelerometers against polysomnography, especially in children. This study evaluated the validity of different algorithms and compared wrist versus ankle accelerometer placements for estimating sleep in children aged 1-12 years. Twenty-nine children undergoing overnight type 1 polysomnography wore ActiGraph accelerometers. Six algorithms were evaluated against polysomnography using Pearson correlations, intraclass correlation, paired t-tests and Bland-Altman plots. Agreement was classified as poor (intraclass correlation coefficient < 0.4), fair (0.4 < intraclass correlation coefficient < 0.6), good (0.6 < intraclass correlation coefficient < 0.75) or excellent (intraclass correlation coefficient > 0.75). Total sleep time was the primary outcome. For wrist-worn devices, the Sadeh (Actilife) and Cole-Kripke (Actilife and GGIR) algorithms showed excellent agreement with polysomnography (intraclass correlation coefficient = 0.80-0.85), while vanHees showed good agreement (intraclass correlation coefficient = 0.67) and Galland showed fair agreement (intraclass correlation coefficient = 0.46). The Cole-Kripke algorithm did not significantly differ from polysomnography total sleep time, whereas others underestimated total sleep time. For ankle-worn devices, Sadeh (Actilife), Cole-Kripke (Actilife) and vanHees algorithms demonstrated excellent agreement (intraclass correlation coefficient = 0.75-0.82). No significant differences were found between wrist and ankle placements for certain algorithms. The findings support accelerometry as a valid tool for sleep assessment in children, recommending that algorithm selection be tailored to specific study requirements. CI - (c) 2024 The Author(s). Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society. FAU - Burger, Pia AU - Burger P AUID- ORCID: 0000-0001-7780-1437 AD - Department of Pediatrics, Emma Children's Hospital, Amsterdam UMC, Amsterdam, Netherlands. AD - Amsterdam Reproduction and Development Research Institute, Amsterdam, Netherlands. AD - Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands. FAU - Kruisinga, Frea H AU - Kruisinga FH AD - Department of Pediatrics, Emma Children's Hospital, Amsterdam UMC, Amsterdam, Netherlands. FAU - Lettink, Anneline AU - Lettink A AD - Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands. AD - Amsterdam UMC Location Vrije Universiteit Amsterdam, Public and Occupational Health, Amsterdam, The Netherlands. FAU - Chinapaw, Mai J M AU - Chinapaw MJM AD - Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands. AD - Amsterdam UMC Location Vrije Universiteit Amsterdam, Public and Occupational Health, Amsterdam, The Netherlands. FAU - Gemke, Reinoud J B J AU - Gemke RJBJ AUID- ORCID: 0000-0001-5603-2640 AD - Department of Pediatrics, Emma Children's Hospital, Amsterdam UMC, Amsterdam, Netherlands. AD - Amsterdam Reproduction and Development Research Institute, Amsterdam, Netherlands. AD - Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands. LA - eng PT - Comparative Study PT - Journal Article PT - Validation Study PT - Validation Study DEP - 20241129 PL - England TA - J Sleep Res JT - Journal of sleep research JID - 9214441 SB - IM MH - *Accelerometry/instrumentation/methods MH - Wrist MH - Ankle MH - *Wearable Electronic Devices MH - *Polysomnography/instrumentation/methods MH - Reproducibility of Results MH - *Algorithms MH - Correlation of Data MH - Humans MH - Male MH - Female MH - Child, Preschool MH - Child MH - Sleep/physiology MH - *Sleep Wake Disorders/diagnosis PMC - PMC12215244 OTO - NOTNLM OT - accelerometry OT - algorithms OT - criterium validation OT - sleep COIS- None. EDAT- 2024/11/30 12:42 MHDA- 2025/07/02 12:28 PMCR- 2025/07/02 CRDT- 2024/11/30 01:23 PHST- 2024/11/13 00:00 [revised] PHST- 2024/09/18 00:00 [received] PHST- 2024/11/16 00:00 [accepted] PHST- 2025/07/02 12:28 [medline] PHST- 2024/11/30 12:42 [pubmed] PHST- 2024/11/30 01:23 [entrez] PHST- 2025/07/02 00:00 [pmc-release] AID - JSR14426 [pii] AID - 10.1111/jsr.14426 [doi] PST - ppublish SO - J Sleep Res. 2025 Aug;34(4):e14426. doi: 10.1111/jsr.14426. Epub 2024 Nov 29. PMID- 39614179 OWN - NLM STAT- MEDLINE DCOM- 20241130 LR - 20250723 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 24 IP - 1 DP - 2024 Nov 29 TI - Prevalence and psycho-social factors associated with alcohol use among primary school-going children aged 6 to 13 years in Mbale district, Uganda: a cross-sectional study. PG - 782 LID - 10.1186/s12887-024-05260-6 [doi] LID - 782 AB - BACKGROUND: Alcohol use among children in low-resource settings has received limited attention. This study investigated the prevalence of and biopsychosocial factors associated with alcohol use among children aged 6 to 13 years enrolled in primary education in Uganda. METHODS: This cross-sectional study conducted in primary schools within Mbale district, employed stratified random sampling to select 470 child-parent dyads. Screening for child alcohol consumption utilized the validated Ugandan (Lumasaaba) version of the Car, Relax, Alone, Forget, Family/Friends, Trouble (CRAFFT) tool. Alcohol Use Disorder (AUD) was diagnosed using the AUD module of the Mini International Neuropsychiatric Interview for children and adolescents (MINI KID). Logistic regression analysis explored associations between alcohol consumption (CRAFFT cut-off score: 1 or more) and biopsychosocial factors (age, sex, nutrition, family dynamics, socioeconomic indicators, and school environment). Data analysis utilized STATA-17 statistical software. RESULTS: The median age of the participants was 11 years, with an interquartile range (IQR) of 9 to 12 years and a male to female ratio of 1:1.3. The screened prevalence of alcohol consumption among the children in the past 12 months was 25.2% (95% CI: 21.4-29.4) and 7.2% (95% CI: 5.1-10.0) were diagnosed with AUD. The study found a comparable prevalence of alcohol use between boys (25.0%, 95% CI: 19.4-31.5) and girls (25.4%, 95% CI: 20.0-31.1). Age-specific variations indicated that early adolescents (10 to 13 years), were more likely to consume alcohol 28.1% (95% CI: 23.5-33.3) compared to pre-adolescent children (6 to 9 years) 17.6% (95% CI: 11.9-25.1) in the past 12 months. Factors associated with alcohol use included single-parent households, lower caregiver education, low socioeconomic status, maternal drinking, food insecurity, under-weight, physical discipline by parents, peer influence, rural school attendance, and the school environment. CONCLUSION: The prevalence of alcohol consumption among children in Mbale district, eastern Uganda was high with one-in-four primary-school-children aged 6 to 13 years consuming alcohol in the past year, and no significant gender differences. It highlights various interconnected factors associated with alcohol use among school-aged children. We recommend awareness campaigns at all levels, stricter implementation of alcohol policies, school prevention programs, and family-focused and socio-economic interventions. Nationwide school surveys should target pre-adolescent alcohol use. CI - (c) 2024. The Author(s). FAU - Nalugya, Joyce Sserunjogi AU - Nalugya JS AD - Department of Psychiatry, Mulago National Referral and Teaching Hospital, Ministry of Health, Kampala, Uganda. joycenalugya@yahoo.com. AD - Department of Psychiatry, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda. joycenalugya@yahoo.com. AD - Centre for International Health, Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway. joycenalugya@yahoo.com. FAU - Nakasujja, Noeline AU - Nakasujja N AD - Department of Psychiatry, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda. FAU - Engebretsen, Ingunn M S AU - Engebretsen IMS AD - Centre for International Health, Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway. FAU - Abbo, Catherine AU - Abbo C AD - Department of Psychiatry, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda. FAU - Tumwine, James K AU - Tumwine JK AD - Department of Pediatrics and Child Health, School of Medicine, Kabale University, Kabale, Uganda. FAU - Musisi, Seggane AU - Musisi S AD - Department of Psychiatry, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda. FAU - Babirye, Juliet N AU - Babirye JN AD - Department of Disease Control, School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda. FAU - Mpungu, Etheldreda Nakimuli AU - Mpungu EN AD - Department of Psychiatry, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda. FAU - Ndeezi, Grace AU - Ndeezi G AD - Department of Pediatrics and Child Health, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda. LA - eng GR - D43 TW010132/TW/FIC NIH HHS/United States GR - 285489/RCN GLOBVAC ES614003/ GR - Grant Number D43TW010132/NH/NIH HHS/United States PT - Journal Article DEP - 20241129 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Uganda/epidemiology MH - Male MH - Cross-Sectional Studies MH - Adolescent MH - Female MH - Child MH - Prevalence MH - Risk Factors MH - *Underage Drinking/statistics & numerical data/psychology MH - Socioeconomic Factors MH - Alcohol Drinking/epidemiology MH - Schools PMC - PMC11605859 OTO - NOTNLM OT - Alcohol use OT - Associated factors OT - Cross-sectional study OT - Primary school-age children OT - Uganda COIS- Declarations. Ethics approval and consent to participate: This study was conducted following ethical principles and obtained approval from the Institutional Review Boards (IRBs) of Makerere University School of Medicine Higher Degrees Research Ethics Committee (SOMREC # REC REF 2018-095), the Regional Committee for Medical Research Ethics (REC) West #107632 and REC South East #50146 and was approved by the Uganda National Council for Science and Technology (UNCST # SS5103). The research protocol adhered to all relevant ethical guidelines, ensuring the protection of the rights and well-being of the study participants. Those with alcohol use problems received counselling and were referred for further support from Mbale Regional Referral Hospital. The parents provided written informed consent and children's assent was sought in an age-appropriate manner. Throughout the study, strict confidentiality and anonymity were maintained to safeguard the privacy of the participants' information. This research adhered to the ethical principles outlined in the Declaration of Helsinki and other applicable guidelines for human research, prioritizing the ethical considerations and welfare of the participants at every stage of the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2024/11/30 11:17 MHDA- 2024/11/30 12:41 PMCR- 2024/11/29 CRDT- 2024/11/29 23:45 PHST- 2024/03/18 00:00 [received] PHST- 2024/11/19 00:00 [accepted] PHST- 2024/11/30 12:41 [medline] PHST- 2024/11/30 11:17 [pubmed] PHST- 2024/11/29 23:45 [entrez] PHST- 2024/11/29 00:00 [pmc-release] AID - 10.1186/s12887-024-05260-6 [pii] AID - 5260 [pii] AID - 10.1186/s12887-024-05260-6 [doi] PST - epublish SO - BMC Pediatr. 2024 Nov 29;24(1):782. doi: 10.1186/s12887-024-05260-6. PMID- 39613445 OWN - NLM STAT- MEDLINE DCOM- 20241129 LR - 20241202 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 14 IP - 11 DP - 2024 Nov 28 TI - Factors influencing postoperative urinary retention after radical hysterectomy for cervical cancer: development and validation of a predictive model in a prospective cohort study in Southwest China. PG - e086706 LID - 10.1136/bmjopen-2024-086706 [doi] LID - e086706 AB - OBJECTIVES: To explore influencing factors for postoperative urinary retention (POUR) in cervical cancer patients and construct and validate a POUR prediction model. DESIGN: A prospective cohort study. SETTING: A large tertiary hospital specialised in child and maternal healthcare in Southwest China. PARTICIPANTS: 1101 patients undergoing cervical cancer surgery at our hospital were enrolled in the analytic cohort between 1 July 2022 and 31 July 2023. Another 205 patients were enrolled in the external validation cohort between 1 August 2023 and 31 October 2023. Demographics and disease-related information were collected to construct a risk prediction model by logistic regression. Univariate analyses and a multivariate logistic regression analysis were conducted to determine possible influencing factors. The discrimination and accuracy of the model were assessed by the area under the curve (AUC) and the concordance index, respectively. RESULTS: Univariate analysis identified duration of surgery, intraoperative bleeding, presence of diabetes, hypertension, ureteral adhesion, wound healing classification, preoperative radio/chemotherapy, category of Body Mass Index, history of urinary diseases, history of caesarean section, postoperative urinary infection and use of analgesia pumps as potential influencing factors (p<0.05). Diabetes, wound healing classification, presurgery radio/chemotherapy, postoperative urinary infection, use of analgesia pumps and pain numerical rating score were founded to be significant factors influencing the occurrence of POUR in cervical cancer patients (p<0.05). A POUR prediction model constructed using the factors demonstrated excellent prediction power, with an AUC of 0.897 (95% CI, 0.877 to 0.916, p<0.001). The sensitivity of the model at the optimal threshold was 0.591, with specificity being 0.747. The receiver operating characteristic curve indicated a good performance of the model. CONCLUSIONS: Presence of diabetes mellitus, wound healing classification, presurgery radio/chemotherapy, postoperative urinary infection, use of analgesia pumps and pain numerical rating score are factors influencing occurrence of POUR in cervical cancer patients. The POUR prediction model developed demonstrates good predictive power and is promising for clinical utility. CI - (c) Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Zuo, Yan AU - Zuo Y AUID- ORCID: 0000-0003-1397-013X AD - West China School of Nursing, Sichuan University/Department of Gynecology and Obstetrics Nursing, West China Second University Hospital, Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China. FAU - Yang, Kaixuan AU - Yang K AD - Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China. FAU - Zhang, Jianjun AU - Zhang J AD - Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China. FAU - Liu, Xinru AU - Liu X AD - Department of Gynecology and Obstetrics Nursing, West China Second University Hospital, Sichuan University/West China School of Nursing, Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China. FAU - Bai, Zhilan AU - Bai Z AD - Department of Gynecology and Obstetrics Nursing, West China Second University Hospital, Sichuan University/West China School of Nursing, Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China. FAU - He, Jingwen AU - He J AD - Department of Gynecology and Obstetrics Nursing, West China Second University Hospital, Sichuan University/West China School of Nursing, Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China. FAU - Hu, Xiaolin AU - Hu X AD - West China School of Nursing, Sichuan University/Department of Nursing, West China Hospital, Sichuan University, Chengdu, Sichuan, China huxiaolin1220@126.com. LA - eng PT - Journal Article PT - Validation Study DEP - 20241128 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Female MH - *Uterine Cervical Neoplasms/surgery MH - Prospective Studies MH - China/epidemiology MH - Middle Aged MH - *Urinary Retention/etiology/epidemiology MH - *Hysterectomy/adverse effects MH - *Postoperative Complications/epidemiology/etiology MH - Adult MH - Risk Factors MH - Logistic Models MH - Risk Assessment/methods MH - Aged MH - ROC Curve PMC - PMC11605827 OTO - NOTNLM OT - GYNAECOLOGY OT - Gynaecological oncology OT - Kidney & urinary tract disorders OT - Quality of Life COIS- Competing interests: None declared. EDAT- 2024/11/30 11:18 MHDA- 2024/11/30 11:19 PMCR- 2024/11/28 CRDT- 2024/11/29 21:14 PHST- 2024/11/30 11:19 [medline] PHST- 2024/11/30 11:18 [pubmed] PHST- 2024/11/29 21:14 [entrez] PHST- 2024/11/28 00:00 [pmc-release] AID - bmjopen-2024-086706 [pii] AID - 10.1136/bmjopen-2024-086706 [doi] PST - epublish SO - BMJ Open. 2024 Nov 28;14(11):e086706. doi: 10.1136/bmjopen-2024-086706. PMID- 39613441 OWN - NLM STAT- MEDLINE DCOM- 20241129 LR - 20241203 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 14 IP - 11 DP - 2024 Nov 28 TI - Psychometric properties and clinical utility of spinal health outcome measures in school-based interventions among children and adolescents: a systematic review protocol. PG - e089929 LID - 10.1136/bmjopen-2024-089929 [doi] LID - e089929 AB - INTRODUCTION: Spinal health in children and adolescents has global implications, impacting school attendance, academic performance and physical activity. Effective school-based interventions are essential for promoting spinal health literacy, positive behaviours and academic success. OBJECTIVES: This review aims to collect data on school-based interventions for spinal health in children and adolescents over the past two decades. It will examine interventions such as education, exercise and appropriate furniture, focusing on outcomes including musculoskeletal pain, posture, sedentary behaviour and academic performance. Additionally, the review will describe the psychometric properties and clinical utility of the outcome measures used in these studies. METHODS AND ANALYSIS: The systematic review will adhere to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, employing the PICO framework to define criteria for participants, interventions, comparisons, outcomes and study designs. Only English studies published between 2004 and 2024 will be included. Relevant databases will be searched using specific keywords derived from the PICO framework. The Critical Appraisal Tool and the COSMIN Risk of Bias tool will be used to evaluate the methodological quality and risk of bias in the selected studies. Review authors will independently assess articles, resolving discrepancies through consensus. Statistical analyses will be performed using CADIMA V.2.2.4.2 April 2023. RESULTS: Data will be collected based on various outcome measures, evaluated with an approved checklist and presented through descriptive narratives and tables. Findings will be disseminated via conference presentations, Faculty Research Day and publication in reputable journals. ETHICS AND DISSEMINATION: The study will adhere to the ethical principles outlined in the Declaration of Helsinki, ensuring a rigorous approach to minimise bias and guarantee valid results. Studies will be selected based on predetermined criteria following a consistent protocol. The findings will be disseminated through presentations and publication in peer-reviewed journals. PROSPERO REGISTRATION NUMBER: The systematic review protocol is registered on PROSPERO (registration number CRD42024543258), with a planned date of commencement from August 2024 to November 2024. CI - (c) Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Nkhata, Loveness A AU - Nkhata LA AUID- ORCID: 0000-0001-8388-8188 AD - Department of Physiotherapy, Stellenbosch University, Stellenbosch, South Africa loveness.nkhata@unza.zm. AD - Department of Physiotherapy, School of Health Sciences, Lusaka, Zambia. FAU - Human, Anri AU - Human A AUID- ORCID: 0000-0002-5960-6256 AD - Department of Physiotherapy, University of Pretoria, Pretoria, South Africa. FAU - Louw, Q A AU - Louw QA AUID- ORCID: 0000-0003-0238-0943 AD - Department of Physiotherapy, Stellenbosch University, Stellenbosch, South Africa. FAU - Brink, Yolandi AU - Brink Y AUID- ORCID: 0000-0002-4904-9433 AD - Department of Physiotherapy, Stellenbosch University, Stellenbosch, South Africa. LA - eng PT - Journal Article DEP - 20241128 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Systematic Reviews as Topic MH - Child MH - Adolescent MH - *Psychometrics MH - *School Health Services MH - Outcome Assessment, Health Care MH - Research Design PMC - PMC11605816 OTO - NOTNLM OT - Adolescents OT - Back pain OT - Musculoskeletal disorders OT - Rehabilitation medicine OT - Spine COIS- Competing interests: None declared. EDAT- 2024/11/30 11:16 MHDA- 2024/11/30 11:17 PMCR- 2024/11/28 CRDT- 2024/11/29 21:13 PHST- 2024/11/30 11:17 [medline] PHST- 2024/11/30 11:16 [pubmed] PHST- 2024/11/29 21:13 [entrez] PHST- 2024/11/28 00:00 [pmc-release] AID - bmjopen-2024-089929 [pii] AID - 10.1136/bmjopen-2024-089929 [doi] PST - epublish SO - BMJ Open. 2024 Nov 28;14(11):e089929. doi: 10.1136/bmjopen-2024-089929. PMID- 39612005 OWN - NLM STAT- MEDLINE DCOM- 20241129 LR - 20261010 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 184 IP - 1 DP - 2024 Nov 29 TI - Italian cross-cultural validation of the STRONGkids tool for pediatric nutritional evaluation. PG - 55 LID - 10.1007/s00431-024-05895-8 [doi] AB - Nutritional assessment plays a pivotal role in individual development and represents a fundamental component in the early identification of nutritional challenges and imbalances in pediatric patients. Among the validated instruments in the literature, the STRONGkids tool is the most utilized. This study aimed to undertake the translation and transcultural validation of the STRONGkids tool. The STRONGkids tool underwent initial validation following the six-phase protocol outlined by Sousa and Rojjanasrirat, after which it was translated into Italian. The final Italian version of STRONGkids was then administered to a cohort of hospitalized children. Collected data underwent analysis to assess its psychometric properties. Through the initial five phases, an Italian version of the STRONGkids tool was developed, which is congruent with the original and widely utilized version. The sixth phase exhibited favorable intra-rater reliability (k = 0.92; 95% CI 0.87-0.97) and inter-rater reliability (k = 0.77; 95% CI 0.68-0.86). Conclusion: The validated Italian version of STRONGkids emerges as a crucial instrument for precise nutritional assessment during hospitalization, ensuring convenience and effectiveness for professionals. Our findings advocate for the adoption of STRONGkids as a tool for screening pediatric nutritional risk in Italy. STRONGkids represents a complementary tool alongside anthropometric evaluations for nurses. Recognizing its importance, nurses can enhance early identification and intervention in pediatric patients' nutritional risk as part of routine care, fostering interdisciplinary collaboration for optimal patient outcomes. CI - (c) 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Salerno, Alessandra AU - Salerno A AD - Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy. FAU - Gazineo, Domenica AU - Gazineo D AUID- ORCID: 0000-0003-1866-3358 AD - Governo Clinico E Qualita, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy. FAU - Lanari, Marcello AU - Lanari M AD - Pediatric Emergency Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy. AD - Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy. FAU - Shehi, Romina AU - Shehi R AD - Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy. FAU - Ricco, Mattia AU - Ricco M AUID- ORCID: 0000-0002-5447-2586 AD - Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy. FAU - La Malfa, Elisa AU - La Malfa E AD - Governo Clinico E Qualita, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy. AD - Dipartimento di medicina, Universita di Parma, Parma, Italy. FAU - De Rosa, Manuela AU - De Rosa M AD - IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy. AD - Professional development and implementation of research in health professions unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. FAU - Decaro, Roberta AU - Decaro R AD - IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy. AD - Postoperative and Abdominal Organ Transplant Intensive Care Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. FAU - Mattioli, Veronica AU - Mattioli V AD - Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy. FAU - Lepore, Virginia AU - Lepore V AD - Pediatric Emergency Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy. FAU - Imeneo, Rosella AU - Imeneo R AD - Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy. FAU - Tomaso, Tindara AU - Tomaso T AD - Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy. FAU - Gennari, Monia AU - Gennari M AD - Pediatric Emergency Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy. FAU - Dondi, Arianna AU - Dondi A AD - Pediatric Emergency Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy. FAU - Leardini, Davide AU - Leardini D AD - Pediatric Hematology and Oncology, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy. FAU - Santandrea, Chiara AU - Santandrea C AD - Pediatric Emergency Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy. FAU - Ciotti, Giorgia AU - Ciotti G AD - Pediatric Emergency Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy. FAU - Bruno, Emanuela AU - Bruno E AD - Pediatric Emergency Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy. FAU - Trani, Michela AU - Trani M AD - Pediatric Emergency Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy. FAU - Godino, Lea AU - Godino L AUID- ORCID: 0000-0002-3763-9372 AD - Medical Genetics Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Via Massarenti, 9, 40138, Bologna, Italy. lea.godino@aosp.bo.it. LA - eng PT - Journal Article PT - Validation Study DEP - 20241129 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Italy MH - *Nutrition Assessment MH - Female MH - Male MH - Reproducibility of Results MH - Child MH - Child, Preschool MH - *Translations MH - *Psychometrics/methods MH - Infant MH - Cross-Cultural Comparison MH - Surveys and Questionnaires MH - Child Nutrition Disorders/diagnosis MH - Adolescent OTO - NOTNLM OT - Nutrition assessment OT - Pediatrics OT - STRONGkids OT - Translation OT - Validation COIS- Declarations. Ethical approval: This study received the endorsement of the Bioethics Committee at the University of Bologna (protocol number 63546). This endorsement highlights the study's commitment to ethical standards crucial for research involving human participants. All participants were provided with a participant information sheet detailing the purpose and methods of the study. They were informed of their voluntary participation and the option to decline without providing a reason. Informed consent was obtained from all subjects involved in the study. Competing interests: The authors declare no competing interests. EDAT- 2024/11/29 12:22 MHDA- 2024/11/29 12:23 CRDT- 2024/11/29 11:15 PHST- 2024/05/07 00:00 [received] PHST- 2024/11/18 00:00 [accepted] PHST- 2024/10/01 00:00 [revised] PHST- 2024/11/29 12:23 [medline] PHST- 2024/11/29 12:22 [pubmed] PHST- 2024/11/29 11:15 [entrez] AID - 10.1007/s00431-024-05895-8 [pii] AID - 10.1007/s00431-024-05895-8 [doi] PST - epublish SO - Eur J Pediatr. 2024 Nov 29;184(1):55. doi: 10.1007/s00431-024-05895-8. PMID- 39610764 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241130 IS - 2475-2991 (Electronic) IS - 2475-2991 (Linking) VI - 8 IP - 11 DP - 2024 Nov TI - Infant diet quality index predicts nutrients of concern and ultra-processed food intake in low-income children in the United States. PG - 104483 LID - 10.1016/j.cdnut.2024.104483 [doi] LID - 104483 AB - BACKGROUND: Diet quality during infancy can influence nutrient intake and ultra-processed foods (UPFs) consumption throughout later childhood. OBJECTIVES: This study investigated the predictive validity of Infant Diet Quality Index (IDQI) scores from 0 to 1 y of age and consumption of select nutrients and UPFs at different time points in low-income children aged 2-5 y. METHODS: Dietary surveys and 24-h dietary recalls collected between ages 0 and 12 months from 2613 Special Supplemental Women, Infants, and Children Infant Toddler Feeding Practices Study-2 participants were used to assess infant diet quality by final IDQI score ranging from 0 (nonadherence to dietary guidelines) to 1 (complete adherence to guidelines). Single 24-h recalls collected across multiple time points per child aged between 2 and 5 y were used to determine nutrient intakes: vitamin B12 (mug), vitamin D (mug), calcium (mg), iron (mg), zinc (mg), potassium (mg), saturated fat (g), dietary fiber (g), and added sugars (g). Likewise, Nova was used to classify foods (to estimate the percentage of energy from foods) by level of industrial processing at each point in time across ages 2-5 y. Survey-weighted regression analyses estimated associations between total IDQI score and nutrient intake and percentage of energy consumption from each Nova food group at each age between 2-5 y. RESULTS: IDQI scores based on diet quality from 0-1 y of age were positively associated with children's dietary fiber and potassium intake at ages 2-5 y. Additionally, IDQI was negatively associated with added sugar intake. No associations were observed between IDQI and saturated fat consumption. IDQI scores at age 1 were positively associated with the percentage of energy attributed to unprocessed/minimally processed foods (20%-23%) and negatively associated with UPF consumption at ages 2-5 y (-24% to -29%). CONCLUSIONS: IDQI predicts intake of select nutrients and UPF consumption among low-income US children aged 2-5 y.This trial was registered at https://clinicaltrials.gov/study/NCT02031978 as "Feeding My Baby - A National WIC Study," NCT02031978. CI - (c) 2024 The Authors. FAU - Chaney, Alana M AU - Chaney AM AD - Meyer Hall, Department of Nutrition, University of California, Davis, CA, United States. FAU - Arnold, Charles D AU - Arnold CD AD - Meyer Hall, Department of Nutrition, University of California, Davis, CA, United States. FAU - Frongillo, Edward A AU - Frongillo EA AD - Department of Health Promotion, Education, and Behavior, University of South Carolina, Columbia, SC, United States. FAU - Ritchie, Lorrene D AU - Ritchie LD AD - Nutrition Policy Institute, Division of Agriculture and Natural Resources, University of California, Oakland, CA, United States. FAU - Steele, Euridice M AU - Steele EM AD - Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil, Sao Paulo, SP, Brazil. FAU - Au, Lauren E AU - Au LE AD - Meyer Hall, Department of Nutrition, University of California, Davis, CA, United States. LA - eng SI - ClinicalTrials.gov/NCT02031978 PT - Journal Article DEP - 20241018 PL - United States TA - Curr Dev Nutr JT - Current developments in nutrition JID - 101717957 PMC - PMC11602980 OTO - NOTNLM OT - Complementary feeding OT - Infant diet OT - Ultra-processed foods OT - children OT - toddlers COIS- The authors report no conflicts of interest. EDAT- 2024/11/29 06:22 MHDA- 2024/11/29 06:23 PMCR- 2024/10/18 CRDT- 2024/11/29 04:20 PHST- 2024/10/10 00:00 [received] PHST- 2024/10/11 00:00 [accepted] PHST- 2024/11/29 06:23 [medline] PHST- 2024/11/29 06:22 [pubmed] PHST- 2024/11/29 04:20 [entrez] PHST- 2024/10/18 00:00 [pmc-release] AID - S2475-2991(24)02417-X [pii] AID - 104483 [pii] AID - 10.1016/j.cdnut.2024.104483 [doi] PST - epublish SO - Curr Dev Nutr. 2024 Oct 18;8(11):104483. doi: 10.1016/j.cdnut.2024.104483. eCollection 2024 Nov. PMID- 39609845 OWN - NLM STAT- MEDLINE DCOM- 20241129 LR - 20241201 IS - 1477-7525 (Electronic) IS - 1477-7525 (Linking) VI - 22 IP - 1 DP - 2024 Nov 28 TI - EQ‑5D‑Y-3L population norms for children and adolescents in Jiangsu, China. PG - 102 LID - 10.1186/s12955-024-02322-2 [doi] LID - 102 AB - OBJECTIVE: This study aims to establish EQ-5D-Y-3L population norms in Jiangsu, China by conducting a large-scale cross-sectional survey. METHODS: Children and adolescents aged 9-17 from three cities of Jiangsu Province were selected by multistage stratified random sampling to complete the EQ-5D-Y-3L instrument independently. Population norms for Jiangsu, China were determined by calculating statistics based on age and gender. Logistic and Tobit regression models were employed to explain the relationship between HRQoL and factors such as sociodemographic characteristics/recent acute symptoms (experienced fever/cough/sore throat/diarrhea in the past two weeks). RESULTS: Three cities yielded 37,574 valid samples (a sample validity rate of 95.4%). The EQ-5D-Y-3L utility values (mean +/- SD) were 0.964 +/- 0.085 for males and 0.958 +/- 0.077 for females. Males scored 85.94 +/- 19.62 and females scored 84.83 +/- 18.45 on the VAS (mean +/- SD), while the percentages of respondents reporting full health ranged from 58.3 to 78.8%. The dimension in which most respondents reported having no problems was "feeling worried, sad, or unhappy" (23.0%). And the lowest HRQoL was shown in the 14-year-old age group. Gender, age, board at school, and BMI were found to have an association with HRQoL. In addition, recent acute symptoms also correlate with some aspects of HRQoL. CONCLUSIONS: This study established EQ-5D-Y-3L population norms in Jiangsu, China for the first time. These norms will support resource allocation decision-making and be used as a reference for health evaluation studies. CI - (c) 2024. The Author(s). FAU - Liang, Junyan AU - Liang J AD - School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, China. FAU - Dong, Huibin AU - Dong H AD - Section of School Health, Changzhou Municipal Center for Disease Control and Prevention, Changzhou, 213022, China. FAU - Yang, Juan AU - Yang J AD - Section of School Health, Huai'an Municipal Center for Disease Control and Prevention, Huai'an, 223001, China. FAU - Xu, Xinpeng AU - Xu X AD - School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, China. FAU - Wu, Qifeng AU - Wu Q AD - School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, China. FAU - Liu, Li AU - Liu L AD - Section of School Health, Nanjing Municipal Center for Disease Control and Prevention, Nanjing, 210003, China. s042324l@126.com. FAU - You, Hua AU - You H AD - School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, China. youhua98@163.com. AD - Institute of Healthy Jiangsu Development, Nanjing Medical University, Nanjing, 211166, China. youhua98@163.com. LA - eng GR - 72074122/National Natural Science Foundation of China/ PT - Journal Article DEP - 20241128 PL - England TA - Health Qual Life Outcomes JT - Health and quality of life outcomes JID - 101153626 SB - IM MH - Humans MH - Male MH - Adolescent MH - Female MH - China MH - Child MH - Cross-Sectional Studies MH - *Quality of Life MH - Surveys and Questionnaires MH - Health Status MH - Psychometrics/instrumentation PMC - PMC11603884 OTO - NOTNLM OT - China OT - EQ-5D-Y-3L OT - Health-related quality of life OT - Population norms OT - Utility value OT - VAS scores COIS- Declarations. Ethical approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Ethical Review Committee of Nanjing Medical University (Ethics approval number: (661/2021)). Consent to participate: Verbal informed consent was obtained from all individual participants and their legal guardians. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2024/11/29 05:21 MHDA- 2024/11/29 06:21 PMCR- 2024/11/28 CRDT- 2024/11/28 23:57 PHST- 2024/05/02 00:00 [received] PHST- 2024/11/20 00:00 [accepted] PHST- 2024/11/29 06:21 [medline] PHST- 2024/11/29 05:21 [pubmed] PHST- 2024/11/28 23:57 [entrez] PHST- 2024/11/28 00:00 [pmc-release] AID - 10.1186/s12955-024-02322-2 [pii] AID - 2322 [pii] AID - 10.1186/s12955-024-02322-2 [doi] PST - epublish SO - Health Qual Life Outcomes. 2024 Nov 28;22(1):102. doi: 10.1186/s12955-024-02322-2. PMID- 39609691 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241201 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 12 IP - 1 DP - 2024 Nov 28 TI - Sociocultural attitudes towards appearance questionnaire-4-revised (SATAQ-4R): validation in a community sample of Norwegian adolescents. PG - 195 LID - 10.1186/s40337-024-01151-4 [doi] LID - 195 AB - BACKGROUND: Negative body image and disordered eating are common among adolescents and young adults. The Sociocultural Attitudes Towards Appearance Questionnaire-4-Revised (SATAQ-4R) captures the internalization of societal appearance ideals and perceived pressures from others but has not been validated in a Norwegian adolescent population. METHODS: The current study explored the factor structure of SATAQ-4R in a sample of adolescent Norwegian males and females (n = 1558, mean age 17.04 +/- 0.95) using confirmatory factor analysis (CFA) for a 6- and 7-factor structure in females, and a 7-factor structure in males. Correlations between subscales, internal consistency and reliability, and comparisons with convergent measures (disordered eating, body mass index, negative influence of social media) were explored. RESULTS: The CFA supported a 7-factor structure of the SATAQ-4R for both males and females. Internal consistency and reliability were acceptable. SATAQ-4R subscales largely correlated with disordered eating and additional convergent measures. CONCLUSIONS: Results confirm the structure and reliability of the SATAQ-4R in a Norwegian adolescent population. The subscales showed good convergent validity, and high scores on internalization and societal pressures were related to higher levels of disordered eating and negative social media influence. The Norwegian version of the SATAQ-4R thus demonstrates good psychometric properties in adolescent males and females, and is well suited to capture internalization and sociocultural pressures that particularly affect adolescents. Results highlight the need to continue working towards reducing adverse internalization and improving body image among adolescents. CI - (c) 2024. The Author(s). FAU - Lie, Selma Overland AU - Lie SO AUID- ORCID: 0000-0002-7120-8840 AD - Regional Department of Eating Disorders, Division of Mental Health and Addiction, Oslo University Hospital-Ulleval, Oslo, Norway. sellie@ous-hf.no. FAU - Bastos, Rafael Valdece Sousa AU - Bastos RVS AUID- ORCID: 0000-0002-1149-0442 AD - Sao Francisco University, Paulista, Brazil. FAU - Sundgot-Borgen, Christine AU - Sundgot-Borgen C AUID- ORCID: 0000-0003-2444-6982 AD - Regional Department of Eating Disorders, Division of Mental Health and Addiction, Oslo University Hospital-Ulleval, Oslo, Norway. AD - Department of Psychology, University of Oslo, Oslo, Norway. FAU - Wisting, Line AU - Wisting L AUID- ORCID: 0000-0002-5424-7290 AD - Regional Department of Eating Disorders, Division of Mental Health and Addiction, Oslo University Hospital-Ulleval, Oslo, Norway. AD - Department of Psychology, Oslo New University College, Oslo, Norway. FAU - Dahlgren, Camilla Lindvall AU - Dahlgren CL AUID- ORCID: 0000-0002-6773-475X AD - Department of Psychology, Oslo New University College, Oslo, Norway. LA - eng PT - Journal Article DEP - 20241128 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC11603771 OAB - Appearance pressures and internalization of appearance ideals are empirically supported risk factors for body dissatisfaction and disordered eating. Having validated tools to measure these risk factors is essential, particularly for young people, as adolescence itself presents an increased risk for the development of eating disorders. The SATAQ-4R is a self-report questionnaire designed to measure the internalization of western beauty standards, and pressure to conform to these. Although the measure has been used in Norwegian research, it hasn't been validated yet. This study aimed to test how well the SATAQ-4R works with Norwegian teenagers. The results showed that it effectively captures the internalization of societal expectations and pressures that particularly affect adolescents. OABL- eng OTO - NOTNLM OT - Disordered eating OT - Internalization OT - Sociocultural pressures OT - Validation COIS- Declarations. Ethics approval and consent to participate: Ethical approval was secured from the Norwegian Committee for Medical and Health Research Ethics (Ref ID 116178) and the local Data Protection Authority. All participants provided written informed consent. The procedures used in this study are in line with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2024/11/29 05:20 MHDA- 2024/11/29 05:21 PMCR- 2024/11/28 CRDT- 2024/11/28 23:49 PHST- 2024/07/09 00:00 [received] PHST- 2024/11/06 00:00 [accepted] PHST- 2024/11/29 05:21 [medline] PHST- 2024/11/29 05:20 [pubmed] PHST- 2024/11/28 23:49 [entrez] PHST- 2024/11/28 00:00 [pmc-release] AID - 10.1186/s40337-024-01151-4 [pii] AID - 1151 [pii] AID - 10.1186/s40337-024-01151-4 [doi] PST - epublish SO - J Eat Disord. 2024 Nov 28;12(1):195. doi: 10.1186/s40337-024-01151-4. PMID- 39608003 OWN - NLM STAT- MEDLINE DCOM- 20241128 LR - 20260127 IS - 1438-8871 (Electronic) IS - 1439-4456 (Print) IS - 1438-8871 (Linking) VI - 26 DP - 2024 Nov 28 TI - Artificial Intelligence Applications to Measure Food and Nutrient Intakes: Scoping Review. PG - e54557 LID - 10.2196/54557 [doi] LID - e54557 AB - BACKGROUND: Accurate measurement of food and nutrient intake is crucial for nutrition research, dietary surveillance, and disease management, but traditional methods such as 24-hour dietary recalls, food diaries, and food frequency questionnaires are often prone to recall error and social desirability bias, limiting their reliability. With the advancement of artificial intelligence (AI), there is potential to overcome these limitations through automated, objective, and scalable dietary assessment techniques. However, the effectiveness and challenges of AI applications in this domain remain inadequately explored. OBJECTIVE: This study aimed to conduct a scoping review to synthesize existing literature on the efficacy, accuracy, and challenges of using AI tools in assessing food and nutrient intakes, offering insights into their current advantages and areas of improvement. METHODS: This review followed the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines. A comprehensive literature search was conducted in 4 databases-PubMed, Web of Science, Cochrane Library, and EBSCO-covering publications from the databases' inception to June 30, 2023. Studies were included if they used modern AI approaches to assess food and nutrient intakes in human subjects. RESULTS: The 25 included studies, published between 2010 and 2023, involved sample sizes ranging from 10 to 38,415 participants. These studies used a variety of input data types, including food images (n=10), sound and jaw motion data from wearable devices (n=9), and text data (n=4), with 2 studies combining multiple input types. AI models applied included deep learning (eg, convolutional neural networks), machine learning (eg, support vector machines), and hybrid approaches. Applications were categorized into dietary intake assessment, food detection, nutrient estimation, and food intake prediction. Food detection accuracies ranged from 74% to 99.85%, and nutrient estimation errors varied between 10% and 15%. For instance, the RGB-D (Red, Green, Blue-Depth) fusion network achieved a mean absolute error of 15% in calorie estimation, and a sound-based classification model reached up to 94% accuracy in detecting food intake based on jaw motion and chewing patterns. In addition, AI-based systems provided real-time monitoring capabilities, improving the precision of dietary assessments and demonstrating the potential to reduce recall bias typically associated with traditional self-report methods. CONCLUSIONS: While AI demonstrated significant advantages in improving accuracy, reducing labor, and enabling real-time monitoring, challenges remain in adapting to diverse food types, ensuring algorithmic fairness, and addressing data privacy concerns. The findings suggest that AI has transformative potential for dietary assessment at both individual and population levels, supporting precision nutrition and chronic disease management. Future research should focus on enhancing the robustness of AI models across diverse dietary contexts and integrating biological sensors for a holistic dietary assessment approach. CI - (c)Jiakun Zheng, Junjie Wang, Jing Shen, Ruopeng An. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 28.11.2024. FAU - Zheng, Jiakun AU - Zheng J AUID- ORCID: 0000-0002-3054-1823 AD - School of Economics and Management, Shanghai University of Sport, Shanghai, China. FAU - Wang, Junjie AU - Wang J AUID- ORCID: 0000-0003-2270-7245 AD - School of Kinesiology and Health Promotion, Dalian University of Technology, Dalian, China. FAU - Shen, Jing AU - Shen J AUID- ORCID: 0000-0001-9751-5454 AD - Department of Physical Education, China University of Geosciences (Beijing), Beijing, China. FAU - An, Ruopeng AU - An R AUID- ORCID: 0000-0001-9632-0209 AD - Silver School of Social Work, New York University, New York, NY, United States. LA - eng PT - Journal Article PT - Scoping Review DEP - 20241128 PL - Canada TA - J Med Internet Res JT - Journal of medical Internet research JID - 100959882 RN - 0 (Nutrients) SB - IM MH - Humans MH - *Artificial Intelligence MH - Nutrition Assessment MH - Eating MH - Adult MH - Female MH - Male MH - Deep Learning MH - Nutrients MH - Child MH - Adolescent PMC - PMC11638690 OTO - NOTNLM OT - AI OT - AI-based OT - artificial intelligence OT - computer vision OT - deep learning OT - diet OT - dietary assessments OT - disease management OT - food OT - food intake OT - machine learning OT - measurement OT - mobile phone OT - natural language processing OT - neural networks OT - nutrient OT - systematic literature COIS- Conflicts of Interest: None declared. EDAT- 2024/11/28 18:25 MHDA- 2024/11/28 18:26 PMCR- 2024/11/28 CRDT- 2024/11/28 16:53 PHST- 2023/11/14 00:00 [received] PHST- 2024/10/08 00:00 [accepted] PHST- 2024/07/18 00:00 [revised] PHST- 2024/11/28 18:26 [medline] PHST- 2024/11/28 18:25 [pubmed] PHST- 2024/11/28 16:53 [entrez] PHST- 2024/11/28 00:00 [pmc-release] AID - v26i1e54557 [pii] AID - 10.2196/54557 [doi] PST - epublish SO - J Med Internet Res. 2024 Nov 28;26:e54557. doi: 10.2196/54557. PMID- 39607888 OWN - NLM STAT- MEDLINE DCOM- 20250715 LR - 20260306 IS - 1945-7197 (Electronic) IS - 0021-972X (Print) IS - 0021-972X (Linking) VI - 110 IP - 8 DP - 2025 Jul 15 TI - Evaluation of Sleep Health in Children With Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency. PG - e2647-e2653 LID - 10.1210/clinem/dgae836 [doi] AB - CONTEXT: Literature on sleep health in children with congenital adrenal hyperplasia (CAH) is sparse despite the important role the hypothalamic-pituitary-adrenal axis plays in sleep onset, duration, and awakenings after sleep onset. OBJECTIVE: To evaluate sleep health in children and adolescents with CAH as measured by wrist actigraphy and validated sleep questionnaires. METHODS: Cross-sectional study at our multidisciplinary CAH clinic. Participants aged 3 to 18 years with classic CAH wore an ActiGraph GT3X+ accelerometer for 1 week. Children and parents completed sleep questionnaires, and the results were compared to published samples from the community and children with sleep disorders (clinical). Actigraphy sleep health measures were compared to consensus sleep duration recommendations and normative data in healthy children. RESULTS: Forty-four participants (23 male) with CAH completed the study. Actigraphy found sleep duration in children with CAH was less than recommended guidelines with significantly worse sleep efficiency and increased wake after sleep onset (P < .05) compared to healthy children. After sleep onset, the average number of awakenings increased from 1.67 per hour during the first 2 hours after the evening hydrocortisone dose to 3.12 per hour 4 to 7 hours after the dose, corresponding with washout of the evening hydrocortisone dose. Parents of 3- to 10-year-olds reported significantly worse sleep onset delay and decreased sleep duration than both the community and clinical samples, and significantly more night awakenings than the community sample. CONCLUSION: Our findings suggest that sleep health is impaired in children with CAH and is an important consideration for both clinical practice and future research. CI - (c) The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society. FAU - Golob, Laura AU - Golob L AD - Division of Pediatric Endocrinology, University of Minnesota Medical School, Minneapolis, MN 55454, USA. FAU - Mercado-Munoz, Yesica AU - Mercado-Munoz Y AD - Division of Pediatric Endocrinology, University of Minnesota Medical School, Minneapolis, MN 55454, USA. FAU - Liu, Wenxi AU - Liu W AD - Department of Physical Education, Shanghai Jiao Tong University, Shanghai 200240, China. FAU - Singh, Anvita AU - Singh A AD - Division of Pediatric Endocrinology, University of Minnesota Medical School, Minneapolis, MN 55454, USA. FAU - Hodges, James S AU - Hodges JS AD - Division of Biostatistics and Health Data Science, University of Minnesota School of Public Health, Minneapolis, MN 55455, USA. FAU - Siegel, Lianne AU - Siegel L AUID- ORCID: 0000-0001-9440-9146 AD - Division of Biostatistics and Health Data Science, University of Minnesota School of Public Health, Minneapolis, MN 55455, USA. FAU - Morero, Helena AU - Morero H AD - Division of Pediatric Pulmonary and Sleep Medicine, University of Minnesota Medical School, Minneapolis, MN 55454, USA. FAU - Gao, Zan AU - Gao Z AD - School of Kinesiology, University of Tennessee, Knoxville, TN 37996, USA. FAU - Tipp, Angela AU - Tipp A AD - Neonatal Care, University of Minnesota Medical Center, Minneapolis, MN 55455, USA. FAU - Simon, Stacey L AU - Simon SL AD - Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. FAU - Sarafoglou, Kyriakie AU - Sarafoglou K AUID- ORCID: 0000-0002-5741-3629 AD - Division of Pediatric Endocrinology, University of Minnesota Medical School, Minneapolis, MN 55454, USA. AD - Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, MN 55455, USA. LA - eng GR - T32 DK065519/DK/NIDDK NIH HHS/United States PT - Journal Article PL - United States TA - J Clin Endocrinol Metab JT - The Journal of clinical endocrinology and metabolism JID - 0375362 RN - Congenital adrenal hyperplasia due to 21 hydroxylase deficiency SB - IM MH - Humans MH - *Adrenal Hyperplasia, Congenital/complications/physiopathology MH - Male MH - Female MH - Child MH - Adolescent MH - Cross-Sectional Studies MH - Child, Preschool MH - Actigraphy MH - *Sleep Wake Disorders/etiology/diagnosis MH - *Sleep/physiology MH - Surveys and Questionnaires PMC - PMC12261079 OTO - NOTNLM OT - congenital adrenal hyperplasia OT - cortisol OT - hydrocortisone OT - hypothalamic-pituitary-adrenal axis OT - sleep EDAT- 2024/11/28 18:25 MHDA- 2025/07/15 12:30 PMCR- 2024/11/28 CRDT- 2024/11/28 13:53 PHST- 2024/08/06 00:00 [received] PHST- 2025/07/15 12:30 [medline] PHST- 2024/11/28 18:25 [pubmed] PHST- 2024/11/28 13:53 [entrez] PHST- 2024/11/28 00:00 [pmc-release] AID - 7912484 [pii] AID - dgae836 [pii] AID - 10.1210/clinem/dgae836 [doi] PST - ppublish SO - J Clin Endocrinol Metab. 2025 Jul 15;110(8):e2647-e2653. doi: 10.1210/clinem/dgae836. PMID- 39602909 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250603 IS - 1421-9697 (Electronic) IS - 0250-6807 (Linking) VI - 80 IP - Suppl 1 DP - 2024 TI - What Is Normal Growth? Principles, Practicalities and Pitfalls of Growth Assessments in Infants and Children. PG - 7-17 LID - 10.1159/000541226 [doi] AB - BACKGROUND: Growth assessments are a pillar of public health surveillance, individual health screening, and clinical care. Normal growth is defined differently for individuals versus populations. The World Health Organization (WHO) growth standards were developed to describe the pattern of growth in healthy children without socioeconomic limitations whose mothers planned to breastfeed. The growth standards' cut-off points of +/-2 standard deviations (z-scores) were defined for population assessments, based on attained size, to describe stunting and wasting at the lower end and overweight at the higher end. In a healthy population, one would expect 2.3% of the population to be above and below these cut-points. Higher child mortality rates associated with higher rates of stunting and wasting noted in observational studies validated these WHO cut-offs. There are knowledge gaps influencing the accuracy and effectiveness of growth assessments in individual children, posing challenges for health care providers. SUMMARY: The principles of assessing normal growth in children and preterm infants are reviewed, along with pitfalls to be avoided. Growth is determined by genetics and modified by the interplay with nutritional, environmental, socioeconomic, and possibly intergenerational factors. This complexity is reflected at both the population and individual level. However, normal growth in an individual has unique-specific factors so requires a comprehensive assessment. Normal growth for an individual child could be defined as the progression of changes in anthropometric measurements to achieve the individual's genetic potential. A misdiagnosis of growth faltering can occur if infants and children are assessed with one-time rather than serial measures, and if age is not corrected for prematurity. Health care provider sensitivity and cognizance when communicating about a child's size is important for parental reassurance and avoiding stigma and unnecessary pressures or restrictions around feeding. CI - (c) 2025 S. Karger AG, Basel. FAU - Fenton, Tanis R AU - Fenton TR AD - Community Health Sciences, O'Brien Institute of Public Health, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. FAU - Gilbert, Nicole AU - Gilbert N AD - Community Health Sciences, O'Brien Institute of Public Health, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. FAU - Elmrayed, Seham AU - Elmrayed S AD - Community Health Sciences, O'Brien Institute of Public Health, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. AD - Institute of Global Health and Human Ecology, American University in Cairo, New Cairo, Egypt. FAU - Fenton, Carol J AU - Fenton CJ AD - School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. FAU - Boctor, Dana L AU - Boctor DL AD - Community Health Sciences, O'Brien Institute of Public Health, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. AD - Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. LA - eng PT - Journal Article PT - Review DEP - 20241127 PL - Switzerland TA - Ann Nutr Metab JT - Annals of nutrition & metabolism JID - 8105511 SB - IM OTO - NOTNLM OT - Failure OT - Growth chart OT - Growth disorders OT - Nutrition assessment OT - Obesity OT - Parents OT - Restriction OT - Retardation OT - Validation EDAT- 2024/11/28 00:24 MHDA- 2024/11/28 00:25 CRDT- 2024/11/27 18:25 PHST- 2024/05/25 00:00 [received] PHST- 2024/08/28 00:00 [accepted] PHST- 2024/11/28 00:25 [medline] PHST- 2024/11/28 00:24 [pubmed] PHST- 2024/11/27 18:25 [entrez] AID - 000541226 [pii] AID - 10.1159/000541226 [doi] PST - ppublish SO - Ann Nutr Metab. 2024;80(Suppl 1):7-17. doi: 10.1159/000541226. Epub 2024 Nov 27. PMID- 39602803 OWN - NLM STAT- MEDLINE DCOM- 20241127 LR - 20250908 IS - 1438-8871 (Electronic) IS - 1439-4456 (Print) IS - 1438-8871 (Linking) VI - 26 DP - 2024 Nov 27 TI - Development and Validation of a Prediction Model Using Sella Magnetic Resonance Imaging-Based Radiomics and Clinical Parameters for the Diagnosis of Growth Hormone Deficiency and Idiopathic Short Stature: Cross-Sectional, Multicenter Study. PG - e54641 LID - 10.2196/54641 [doi] LID - e54641 AB - BACKGROUND: Growth hormone deficiency (GHD) and idiopathic short stature (ISS) are the major etiologies of short stature in children. For the diagnosis of GHD and ISS, meticulous evaluations are required, including growth hormone provocation tests, which are invasive and burdensome for children. Additionally, sella magnetic resonance imaging (MRI) is necessary for assessing etiologies of GHD, which cannot evaluate hormonal secretion. Recently, radiomics has emerged as a revolutionary technique that uses mathematical algorithms to extract various features for the quantitative analysis of medical images. OBJECTIVE: This study aimed to develop a machine learning-based model using sella MRI-based radiomics and clinical parameters to diagnose GHD and ISS. METHODS: A total of 293 children with short stature who underwent sella MRI and growth hormone provocation tests were included in the training set, and 47 children who met the same inclusion criteria were enrolled in the test set from different hospitals for this study. A total of 186 radiomic features were extracted from the pituitary glands using a semiautomatic segmentation process for both the T2-weighted and contrast-enhanced T1-weighted image. The clinical parameters included auxological data, insulin-like growth factor-I, and bone age. The extreme gradient boosting algorithm was used to train the prediction models. Internal validation was conducted using 5-fold cross-validation on the training set, and external validation was conducted on the test set. Model performance was assessed by plotting the area under the receiver operating characteristic curve. The mean absolute Shapley values were computed to quantify the impact of each parameter. RESULTS: The area under the receiver operating characteristic curves (95% CIs) of the clinical, radiomics, and combined models were 0.684 (0.590-0.778), 0.691 (0.620-0.762), and 0.830 (0.741-0.919), respectively, in the external validation. Among the clinical parameters, the major contributing factors to prediction were BMI SD score (SDS), chronological age-bone age, weight SDS, growth velocity, and insulin-like growth factor-I SDS in the clinical model. In the combined model, radiomic features including maximum probability from a T2-weighted image and run length nonuniformity normalized from a T2-weighted image added incremental value to the prediction (combined model vs clinical model, P=.03; combined model vs radiomics model, P=.02). The code for our model is available in a public repository on GitHub. CONCLUSIONS: Our model combining both radiomics and clinical parameters can accurately predict GHD from ISS, which was also proven in the external validation. These findings highlight the potential of machine learning-based models using radiomics and clinical parameters for diagnosing GHD and ISS. CI - (c)Kyungchul Song, Taehoon Ko, Hyun Wook Chae, Jun Suk Oh, Ho-Seong Kim, Hyun Joo Shin, Jeong-Ho Kim, Ji-Hoon Na, Chae Jung Park, Beomseok Sohn. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 27.11.2024. FAU - Song, Kyungchul AU - Song K AUID- ORCID: 0000-0002-8497-5934 AD - Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Ko, Taehoon AU - Ko T AUID- ORCID: 0000-0002-4045-0036 AD - Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. AD - Department of Medical Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. AD - The Catholic Medical Center Institute for Basic Medical Science, The Catholic Medical Center of The Catholic University of Korea, Seoul, Republic of Korea. FAU - Chae, Hyun Wook AU - Chae HW AUID- ORCID: 0000-0001-5016-8539 AD - Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Oh, Jun Suk AU - Oh JS AUID- ORCID: 0000-0002-5765-2347 AD - Deparment of Pediatrics, Konyang University College of Medicine, Daejeon, Republic of Korea. FAU - Kim, Ho-Seong AU - Kim HS AUID- ORCID: 0000-0003-1135-099X AD - Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Shin, Hyun Joo AU - Shin HJ AUID- ORCID: 0000-0002-7462-2609 AD - Department of Radiology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, Gyeonggi-do, Republic of Korea. FAU - Kim, Jeong-Ho AU - Kim JH AUID- ORCID: 0000-0003-2479-0548 AD - Department of Laboratory Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, Gyeonggi-do, Republic of Korea. FAU - Na, Ji-Hoon AU - Na JH AUID- ORCID: 0000-0002-3051-2010 AD - Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Park, Chae Jung AU - Park CJ AUID- ORCID: 0000-0002-5567-8658 AD - Department of Radiology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, Gyeonggi-do, Republic of Korea. FAU - Sohn, Beomseok AU - Sohn B AUID- ORCID: 0000-0002-6765-8056 AD - Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. LA - eng GR - 27301C0040/ES/NIEHS NIH HHS/United States PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20241127 PL - Canada TA - J Med Internet Res JT - Journal of medical Internet research JID - 100959882 RN - 12629-01-5 (Human Growth Hormone) SB - IM MH - Humans MH - *Magnetic Resonance Imaging/methods MH - Child MH - Male MH - Cross-Sectional Studies MH - Female MH - Human Growth Hormone/deficiency MH - Machine Learning MH - Adolescent MH - Growth Disorders/diagnostic imaging MH - Radiomics PMC - PMC11635315 OTO - NOTNLM OT - MRI OT - adolescent OT - child OT - dwarfism OT - idiopathic short stature OT - machine learning OT - magnetic resonance imaging OT - pituitary COIS- Conflicts of Interest: None declared. EDAT- 2024/11/27 18:25 MHDA- 2024/11/27 18:26 PMCR- 2024/11/27 CRDT- 2024/11/27 16:53 PHST- 2023/11/16 00:00 [received] PHST- 2024/10/02 00:00 [accepted] PHST- 2024/04/15 00:00 [revised] PHST- 2024/11/27 18:26 [medline] PHST- 2024/11/27 18:25 [pubmed] PHST- 2024/11/27 16:53 [entrez] PHST- 2024/11/27 00:00 [pmc-release] AID - v26i1e54641 [pii] AID - 10.2196/54641 [doi] PST - epublish SO - J Med Internet Res. 2024 Nov 27;26:e54641. doi: 10.2196/54641. PMID- 39600534 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250530 IS - 2055-2238 (Electronic) IS - 2055-2238 (Linking) VI - 10 IP - 6 DP - 2024 Dec TI - Childhood Body Fat Patterns and Obesity Prevalence in Kazakhstan. PG - e70024 LID - 10.1002/osp4.70024 [doi] LID - e70024 AB - BACKGROUND: In Kazakhstan the pediatric population levels of obesity based on fat mass (FM) assessment are currently unknown. The present work aimed to assess average childhood FM levels and the prevalence of high levels of adiposity (based upon FM levels). METHODS: Cross-sectional data from 2015 to 2020 nationally representative Childhood obesity surveillance initiative and 2022 regional surveys were used for this study of children aged 8 years (n = 4770) and 9 years (n = 3863). Childhood FM assessment was made using a validated prediction model using height, weight, age, sex and ethnicity. Average levels of FM, fat mass percent (FM%) and the prevalence of overfat and obesity were estimated. RESULTS: Amongst 8-year-olds, the population average FM% was 32.3% (95% CI: 31.7%-32.8%) for boys and 35.2% (95% CI: 34.8-35.6) for girls (2015) and 32.7% (95% CI: 32.3-33.1) for boys and 35.1% (95% CI: 34.7-35.5) for girls in 2020. The Almaty region had the average FM% 32.7% (95% CI: 32.1-33.2) and 34.8% (95% CI: 34.3-35.4) for boys and girls respectively in 2022. The similar pattern was observed for 9 year old children. CONCLUSIONS: The present study reveals high FM% levels in primary school age children from Kazakhstan across study years. Understanding patterns of FM levels is important for preventing and addressing childhood obesity. CI - (c) 2024 The Author(s). Obesity Science & Practice published by World Obesity and The Obesity Society and John Wiley & Sons Ltd. FAU - Abdrakhmanova, Shynar AU - Abdrakhmanova S AUID- ORCID: 0000-0003-3504-0427 AD - The National Center of Public Healthcare of the Ministry of Health of the Republic of Kazakhstan Almaty Kazakhstan. AD - KMU "Kazakhstan School of Public Health" Almaty Kazakhstan. FAU - Aringazina, Altyn AU - Aringazina A AD - Almaty Management University AlmaU Almaty Kazakhstan. AD - Caspian University Almaty Kazakhstan. FAU - Kalmakova, Zhanar AU - Kalmakova Z AD - Kyzylorda High Medical College Kyzylorda Kazakhstan. FAU - Utemissova, Laura AU - Utemissova L AD - World Health Organization Country Office Astana Kazakhstan. FAU - Heinen, Mirjam AU - Heinen M AD - Special Initiative on NCDs and Innovation WHO Regional Office for Europe Copenhagen Denmark. FAU - Buoncristiano, Marta AU - Buoncristiano M AD - Special Initiative on NCDs and Innovation WHO Regional Office for Europe Copenhagen Denmark. FAU - Williams, Julianne AU - Williams J AD - Special Initiative on NCDs and Innovation WHO Regional Office for Europe Copenhagen Denmark. FAU - Wickramasinghe, Kremlin AU - Wickramasinghe K AD - Special Initiative on NCDs and Innovation WHO Regional Office for Europe Copenhagen Denmark. FAU - Hudda, Mohammed T AU - Hudda MT AD - Department of Population Health Dasman Diabetes Institute Kuwait City Kuwait. LA - eng GR - 001/WHO_/World Health Organization/International PT - Journal Article DEP - 20241126 PL - United States TA - Obes Sci Pract JT - Obesity science & practice JID - 101675151 PMC - PMC11589656 OTO - NOTNLM OT - body composition OT - fat mass prediction equation OT - pediatric obesity COIS- The authors declare no conflicts of interest. EDAT- 2024/11/27 11:18 MHDA- 2024/11/27 11:19 PMCR- 2024/11/26 CRDT- 2024/11/27 04:08 PHST- 2024/05/24 00:00 [received] PHST- 2024/10/29 00:00 [revised] PHST- 2024/11/07 00:00 [accepted] PHST- 2024/11/27 11:19 [medline] PHST- 2024/11/27 11:18 [pubmed] PHST- 2024/11/27 04:08 [entrez] PHST- 2024/11/26 00:00 [pmc-release] AID - OSP470024 [pii] AID - 10.1002/osp4.70024 [doi] PST - epublish SO - Obes Sci Pract. 2024 Nov 26;10(6):e70024. doi: 10.1002/osp4.70024. eCollection 2024 Dec. PMID- 39599710 OWN - NLM STAT- MEDLINE DCOM- 20241127 LR - 20241130 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 22 DP - 2024 Nov 17 TI - Dietary Challenges in Children with Gluten-Related Disorders: A Study on Food Neophobia. LID - 10.3390/nu16223924 [doi] LID - 3924 AB - BACKGROUND/OBJECTIVES: Food neophobia (FN) in childhood is characterized by resistance to new foods, potentially impairing health and diet quality and impacting physical and mental development. Adequate nutrition in early childhood is crucial to preventing future problems. FN demands special attention, especially in cases of gluten-related disorders (GRD), due to the risks associated with restrictive diets and food allergies. The objective of this study was to investigate and classify the prevalence of FN among Brazilian children aged 4 to 11 years with GRD. METHODS: For this cross-sectional study, a questionnaire validated in Portuguese, with 25 items, assessed FN in three domains: general FN, FN of fruits, and FN of vegetables. Data were collected via Google Forms. RESULTS: Of 209 children with GRD, the majority were female, 83.7% were diagnosed with celiac conditions, 81.3% followed a diet, and 43.1% had moderate total food neophobia. Brazilian children with GRD have a moderate prevalence of food neophobia. General and vegetable neophobia predominate, while fruit FN is lower. Girls exhibit greater neophobia towards vegetables. CONCLUSIONS: Neophobia does not vary with age, suggesting the persistence of the behavior and potential nutritional challenges in adult life. Differentiated attention to this population is essential to minimize long-term impacts. FAU - Nogueira Firme, Julyana AU - Nogueira Firme J AUID- ORCID: 0000-0002-4950-7115 AD - Human Nutrition Graduate Program, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Dos Santos, Emanuele Batistela AU - Dos Santos EB AUID- ORCID: 0000-0002-8214-7887 AD - Department of Food and Nutrition, Federal University of Mato Grosso, Cuiaba 78060-900, Brazil. FAU - Zandonadi, Renata Puppin AU - Zandonadi RP AUID- ORCID: 0000-0003-0370-3089 AD - Nutrition Department, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Nakano, Eduardo Yoshio AU - Nakano EY AUID- ORCID: 0000-0002-9071-8512 AD - Department of Statistics, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Botelho, Raquel Braz Assuncao AU - Botelho RBA AUID- ORCID: 0000-0002-0369-287X AD - Nutrition Department, University of Brasilia, Brasilia 70910-900, Brazil. LA - eng PT - Journal Article DEP - 20241117 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 8002-80-0 (Glutens) SB - IM MH - Humans MH - Female MH - Child MH - Male MH - Child, Preschool MH - Cross-Sectional Studies MH - Brazil/epidemiology MH - *Avoidant Restrictive Food Intake Disorder MH - Surveys and Questionnaires MH - Celiac Disease/psychology/epidemiology MH - Vegetables MH - Diet MH - Prevalence MH - Fruit MH - Glutens/adverse effects MH - Feeding Behavior/psychology MH - Food Hypersensitivity/psychology/epidemiology PMC - PMC11597788 OTO - NOTNLM OT - celiac disease OT - child OT - eating behavior OT - food neophobia OT - gluten-related disorder COIS- The authors declare no conflicts of interest. EDAT- 2024/11/27 06:20 MHDA- 2024/11/27 12:38 PMCR- 2024/11/17 CRDT- 2024/11/27 01:42 PHST- 2024/10/29 00:00 [received] PHST- 2024/11/11 00:00 [revised] PHST- 2024/11/12 00:00 [accepted] PHST- 2024/11/27 12:38 [medline] PHST- 2024/11/27 06:20 [pubmed] PHST- 2024/11/27 01:42 [entrez] PHST- 2024/11/17 00:00 [pmc-release] AID - nu16223924 [pii] AID - nutrients-16-03924 [pii] AID - 10.3390/nu16223924 [doi] PST - epublish SO - Nutrients. 2024 Nov 17;16(22):3924. doi: 10.3390/nu16223924. PMID- 39599683 OWN - NLM STAT- MEDLINE DCOM- 20241127 LR - 20241130 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 22 DP - 2024 Nov 15 TI - The Development of a Food Frequency Questionnaire for the Assessment of Ultra-Processed Food Consumption in the Italian Adult Population: Protocol for a Validity and Reproducibility Study. LID - 10.3390/nu16223896 [doi] LID - 3896 AB - BACKGROUND: Over the last decade, while studies on the detrimental effects of ultra-processed food (UPF) consumption have increased, methodological limitations on the quality of available evidence have emerged. Starting from a critical reassessment of the NOVA classification, this project will aim to develop and validate a food frequency questionnaire (FFQ), which is based on the processing of consumed foods and specifically designed to estimate the UPF consumption and total dietary intake of macro- and micronutrients in the Italian adult population. METHODS: This study will take place in selected workplaces and include healthy males and females aged >/=18 years, residing in Italy and with Italian citizenship. The FFQ will be online, voluntary, self-administered, semi-quantitative, and designed to assess food intake over the past year and distinguish between industrial, artisanal, and home-made products. This project will consist of two phases. First, a pilot study will be conducted to obtain the final version of the FFQ. The current food consumption of the target population will be investigated, through a 24 h dietary recall, and the face validity of the new tool will be tested. The second phase will involve at least 436 participants. To assess reproducibility, the FFQ will be administered twice (at an interval of 3-10 months), and the test-retest method will be used. A 7-day weighed dietary record (WDR) will also be completed after each FFQ administration. To evaluate criterion validity, data from the two WDRs will be compared against those from the first FFQ administration. CONCLUSIONS: The results will provide a new valid tool focused on food processing, potentially useful for future studies. FAU - Cardamone, Erica AU - Cardamone E AUID- ORCID: 0009-0007-9926-846X AD - Department of Medicine-DMED, University of Udine, 33100 Udine, Italy. AD - Unit of Human Nutrition and Health, Department of Food Safety, Nutrition and Veterinary Public Health, Italian National Institute of Health, 00161 Rome, Italy. FAU - Iacoponi, Francesca AU - Iacoponi F AUID- ORCID: 0000-0001-6298-0700 AD - Unit of Human Nutrition and Health, Department of Food Safety, Nutrition and Veterinary Public Health, Italian National Institute of Health, 00161 Rome, Italy. FAU - Fiori, Federica AU - Fiori F AUID- ORCID: 0000-0003-2886-8074 AD - Department of Medicine-DMED, University of Udine, 33100 Udine, Italy. FAU - Marinoni, Michela AU - Marinoni M AD - Branch of Medical Statistics, Biometry and Epidemiology "G. A. Maccacaro", Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy. FAU - Agrimi, Umberto AU - Agrimi U AD - Unit of Human Nutrition and Health, Department of Food Safety, Nutrition and Veterinary Public Health, Italian National Institute of Health, 00161 Rome, Italy. FAU - Silano, Marco AU - Silano M AUID- ORCID: 0000-0002-7051-3405 AD - Department of Cardiovascular, Endocrine-Metabolic Diseases and Aging, Italian National Institute of Health, 00161 Rome, Italy. FAU - Parpinel, Maria AU - Parpinel M AUID- ORCID: 0000-0003-1309-4467 AD - Department of Medicine-DMED, University of Udine, 33100 Udine, Italy. LA - eng PT - Journal Article PT - Validation Study DEP - 20241115 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Italy MH - Male MH - Adult MH - Reproducibility of Results MH - Female MH - *Diet Surveys/standards/methods MH - Surveys and Questionnaires/standards MH - *Fast Foods/statistics & numerical data MH - Middle Aged MH - Pilot Projects MH - Young Adult MH - Feeding Behavior MH - Food Handling MH - Diet/statistics & numerical data MH - Diet Records MH - Adolescent MH - Food, Processed PMC - PMC11597269 OTO - NOTNLM OT - NOVA classification OT - food frequency questionnaire OT - reproducibility OT - ultra-processed foods OT - validity COIS- The authors declare no conflicts of interest. EDAT- 2024/11/27 06:19 MHDA- 2024/11/27 12:38 PMCR- 2024/11/15 CRDT- 2024/11/27 01:42 PHST- 2024/10/24 00:00 [received] PHST- 2024/11/12 00:00 [revised] PHST- 2024/11/13 00:00 [accepted] PHST- 2024/11/27 12:38 [medline] PHST- 2024/11/27 06:19 [pubmed] PHST- 2024/11/27 01:42 [entrez] PHST- 2024/11/15 00:00 [pmc-release] AID - nu16223896 [pii] AID - nutrients-16-03896 [pii] AID - 10.3390/nu16223896 [doi] PST - epublish SO - Nutrients. 2024 Nov 15;16(22):3896. doi: 10.3390/nu16223896. PMID- 39599605 OWN - NLM STAT- MEDLINE DCOM- 20241127 LR - 20241130 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 22 DP - 2024 Nov 7 TI - Evaluation of the Dietary Habits of Polish and Greek University Students in the Context of the Health Benefits of Their Diets. LID - 10.3390/nu16223819 [doi] LID - 3819 AB - Background/Objectives: Eating habits and behaviors play a central role in maintaining health and overall well-being. In the case of young students, they affect not only appearance and general mood but also cognitive ability, concentration, and broader learning ability. For this reason, it is essential for young people to have well-balanced and wholesome diets. Methods: The study included 186 Polish and 136 Greek university students majoring in sports. The research tool was the validated survey questionnaire FFQ-6, and the data collected were additionally used to calculate the healthy diet index (pHDI-10). Results: Based on the analysis of the collected data, the dietary habits of the students surveyed were assessed, taking into account, among other things, the frequency of consumption of sweets, salty snacks, processed foods, and sweetened drinks, but also healthy products, including vegetables and fruit or vegetable and fruit juices. The data collected made it possible to determine an index of the health value of the participants' diet. Conclusions: The analysis of the collected data led to the conclusion that, more often than their Greek peers, Polish university students tend to reach for sweets, salty snacks, or sweetened drinks. Greeks were more likely to choose fruit and vegetables and vegetable and fruit juices. However, among both Poles and Greeks, the index of the health-promoting value of the diet is low, indicating a high risk of diet-related diseases of lifestyle. Similar trends can be observed among students of almost all nationalities, which makes it reasonable to consider the implementation of appropriate educational programs on nutrition and healthy lifestyle principles in general. FAU - Widlak, Patrycja AU - Widlak P AUID- ORCID: 0000-0003-3433-1310 AD - Department of Human Biology, The Faculty of Physical Education, Jozef Pilsudski University of Physical Education in Warsaw, 00-968 Warsaw, Poland. FAU - Malara, Marzena AU - Malara M AD - Department of Human Biology, The Faculty of Physical Education, Jozef Pilsudski University of Physical Education in Warsaw, 00-968 Warsaw, Poland. FAU - Tomczyk, Lukasz AU - Tomczyk L AUID- ORCID: 0000-0002-4644-0111 AD - Department of Food Quality and Safety Management, Faculty of Food Science and Nutrition, Poznan University of Life Sciences, 60-637 Poznan, Poland. FAU - Dania, Aspasia AU - Dania A AUID- ORCID: 0000-0003-2829-0479 AD - School of Physical Education and Sport Science, National and Kapodistrian University of Athens, 17237 Athens, Greece. FAU - Panagiotakou, Georgia AU - Panagiotakou G AD - School of Physical Education and Sport Science, National and Kapodistrian University of Athens, 17237 Athens, Greece. FAU - Papoulia, Georgia AU - Papoulia G AD - School of Physical Education and Sport Science, National and Kapodistrian University of Athens, 17237 Athens, Greece. LA - eng GR - no number/This research was funded by the Rector's Jozef Pilsudski University of Physical Education in War-saw, Poland resources./ PT - Journal Article DEP - 20241107 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Poland MH - *Students/statistics & numerical data MH - Female MH - Universities MH - *Feeding Behavior MH - Greece MH - Male MH - Young Adult MH - *Diet, Healthy/statistics & numerical data MH - Adult MH - Surveys and Questionnaires MH - Adolescent MH - Diet Surveys MH - Diet/statistics & numerical data MH - Vegetables MH - Snacks PMC - PMC11597848 OTO - NOTNLM OT - healthy diet OT - lifestyle OT - nutrition COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2024/11/27 06:19 MHDA- 2024/11/27 06:20 PMCR- 2024/11/07 CRDT- 2024/11/27 01:41 PHST- 2024/09/03 00:00 [received] PHST- 2024/10/23 00:00 [revised] PHST- 2024/11/02 00:00 [accepted] PHST- 2024/11/27 06:20 [medline] PHST- 2024/11/27 06:19 [pubmed] PHST- 2024/11/27 01:41 [entrez] PHST- 2024/11/07 00:00 [pmc-release] AID - nu16223819 [pii] AID - nutrients-16-03819 [pii] AID - 10.3390/nu16223819 [doi] PST - epublish SO - Nutrients. 2024 Nov 7;16(22):3819. doi: 10.3390/nu16223819. PMID- 39599596 OWN - NLM STAT- MEDLINE DCOM- 20241127 LR - 20241130 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 22 DP - 2024 Nov 7 TI - Validity and Reproducibility of a Spanish EPIC Food Frequency Questionnaire in Children and Adolescents. LID - 10.3390/nu16223809 [doi] LID - 3809 AB - BACKGROUND: Dietary habits are crucial for preventing many diseases, particularly in children and adolescents. Accurate assessment of dietary intake is essential for understanding the relationship between diet and health in these age groups. OBJECTIVE: This study aimed to evaluate the reproducibility and validity of a Spanish version of the European Prospective Investigation into Cancer and Nutrition (EPIC) Food Frequency Questionnaire (FFQ) in 150 Spanish children and adolescents aged 10 to 17 using the average of 9 days of 24-h dietary recall (24H-DR) as a reference. METHODS: Intraclass correlation coefficients (ICCs) were calculated to asses reproducibility and Spearman/Pearson correlation coefficients were calculated to assess validity and reproducibility. RESULTS: The average ICCs were 0.41 for crude nutrients, 0.31 for food groups, 0.31 for energy-adjusted nutrients, and 0.4 for energy-adjusted food groups. Spearman/Pearson correlation coefficients averaged 0.39 and 0.41 for crude and energy-adjusted nutrients, respectively, and 0.51 and 0.47 for corresponding food groups. Regarding validity, the average correlation coefficient for crude, energy-adjusted, and de-attenuated nutrients was 0.32, 0.50, and 0.50, respectively. The highest crude coefficient was 0.50 for vitamin C and fiber, while the highest energy-adjusted coefficient was 0.76 for protein and carbohydrates. The highest de-attenuated coefficient was 0.72 for vitamin B6. CONCLUSIONS: Overall, these results suggest that the EPIC FFQ is a valid and reliable instrument for assessing dietary intake in Spanish children and adolescents. FAU - Larroya, Ana AU - Larroya A AD - Microbiome, Nutrition & Health Research Group, Institute of Agrochemistry and Food Technology, Spanish National Research Council (IATA-CSIC), 46980 Valencia, Spain. FAU - Tamayo, Maria AU - Tamayo M AUID- ORCID: 0000-0001-9384-6416 AD - Microbiome, Nutrition & Health Research Group, Institute of Agrochemistry and Food Technology, Spanish National Research Council (IATA-CSIC), 46980 Valencia, Spain. AD - Department of Medicine, Autonomous University of Madrid, 28029 Madrid, Spain. FAU - Cenit, Maria Carmen AU - Cenit MC AD - Microbiome, Nutrition & Health Research Group, Institute of Agrochemistry and Food Technology, Spanish National Research Council (IATA-CSIC), 46980 Valencia, Spain. FAU - Sanz, Yolanda AU - Sanz Y AUID- ORCID: 0000-0002-1615-1976 AD - Microbiome, Nutrition & Health Research Group, Institute of Agrochemistry and Food Technology, Spanish National Research Council (IATA-CSIC), 46980 Valencia, Spain. LA - eng GR - PID2023-430 150693OB-I00/Spanish Ministry of Science and Innovation/ GR - CA1/RSUE/2021-00467/Margarita Salas contract/ GR - AGROALNEXT/2022/049/AGROALNEXT program upported by the Spanish Ministry of Science, Innovation and Universities (MCIU) with funding from European Union NextGenerationEU (PRTR-C17.I1) and Generalitat Valenciana/ GR - Ref. CEX2021-001189-S/Grant "Severo Ochoa" from the National Agency for Research (AEI)- Spanish Ministry of Science and Innovation/ PT - Journal Article PT - Validation Study DEP - 20241107 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - Adolescent MH - Female MH - Reproducibility of Results MH - Male MH - Spain MH - Surveys and Questionnaires/standards MH - *Feeding Behavior MH - *Diet Surveys/standards MH - Diet/statistics & numerical data MH - Energy Intake MH - Prospective Studies MH - Nutrition Assessment PMC - PMC11597864 OTO - NOTNLM OT - 24H-DR OT - EPIC OT - FFQ OT - adolescents OT - children OT - dietary assessment OT - nutrient intake OT - reproducibility OT - validity COIS- The authors declare no conflicts of interest. EDAT- 2024/11/27 06:19 MHDA- 2024/11/27 12:38 PMCR- 2024/11/07 CRDT- 2024/11/27 01:41 PHST- 2024/09/12 00:00 [received] PHST- 2024/10/25 00:00 [revised] PHST- 2024/10/30 00:00 [accepted] PHST- 2024/11/27 12:38 [medline] PHST- 2024/11/27 06:19 [pubmed] PHST- 2024/11/27 01:41 [entrez] PHST- 2024/11/07 00:00 [pmc-release] AID - nu16223809 [pii] AID - nutrients-16-03809 [pii] AID - 10.3390/nu16223809 [doi] PST - epublish SO - Nutrients. 2024 Nov 7;16(22):3809. doi: 10.3390/nu16223809. PMID- 39595796 OWN - NLM STAT- MEDLINE DCOM- 20241127 LR - 20260727 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 21 IP - 11 DP - 2024 Nov 18 TI - Diabetes-Related Knowledge, Attitude, and Practice Towards Exercise and Its Benefits Among Individuals with Type 2 Diabetes Mellitus. LID - 10.3390/ijerph21111529 [doi] LID - 1529 AB - Regular exercise has been shown to have a positive effect on the health outcomes of individuals with type 2 diabetes mellitus (T2DM); however, it is still underutilized in developing countries. This study investigated diabetes-related knowledge, attitudes, and practice toward exercise and its benefits among individuals with T2DM. A total of one hundred and ninety-nine participants (male = 21.6% and female = 78.4%) with T2DM, aged between 18 and 75, (43.77 SD+/- 14.78) years, participated in the study. A validated diabetes-related knowledge, attitude, and practice questionnaire, evaluated by true/false or unsure, was utilized in the study. Descriptive and inferential statistics analysis was used to analyze data with the significance set at p < 0.05. The results demonstrated poor diabetes-related knowledge of exercise (p < 0.001). The majority of the study participants, 163 (81.90%) with T2DM, did not know that physical activity and exercise are different. About 158 (70.40%) of the study participants felt that their regular work was an adequate substitution for exercise. More than 50% of the study participants demonstrated a positive practice towards exercise and its benefits towards T2DM (p < 0.001). The majority of the study participants reported poor knowledge and a negative attitude toward diabetes. However, their diabetes-related practices were satisfactory. FAU - Mtshali, Nokuthula AU - Mtshali N AD - Discipline of Biokinetics, Exercise and Leisure Sciences, School of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa. FAU - Sookan-Kassie, Takshita AU - Sookan-Kassie T AUID- ORCID: 0000-0002-5469-6395 AD - Discipline of Biokinetics, Exercise and Leisure Sciences, School of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241118 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/psychology/therapy MH - Male MH - *Health Knowledge, Attitudes, Practice MH - Female MH - *Exercise MH - Middle Aged MH - Adult MH - Aged MH - Young Adult MH - Adolescent MH - Surveys and Questionnaires MH - Cross-Sectional Studies PMC - PMC11593885 OTO - NOTNLM OT - attitude OT - knowledge OT - physical activity OT - practice OT - type 2 diabetes mellitus COIS- The authors declare no conflict of interest. EDAT- 2024/11/27 06:20 MHDA- 2024/11/27 12:33 PMCR- 2024/11/18 CRDT- 2024/11/27 01:19 PHST- 2024/08/14 00:00 [received] PHST- 2024/11/04 00:00 [revised] PHST- 2024/11/12 00:00 [accepted] PHST- 2024/11/27 12:33 [medline] PHST- 2024/11/27 06:20 [pubmed] PHST- 2024/11/27 01:19 [entrez] PHST- 2024/11/18 00:00 [pmc-release] AID - ijerph21111529 [pii] AID - ijerph-21-01529 [pii] AID - 10.3390/ijerph21111529 [doi] PST - epublish SO - Int J Environ Res Public Health. 2024 Nov 18;21(11):1529. doi: 10.3390/ijerph21111529. PMID- 39595776 OWN - NLM STAT- MEDLINE DCOM- 20241127 LR - 20260727 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 21 IP - 11 DP - 2024 Nov 13 TI - Validity and Reliability of the Transcultural Arabic Adaptation of the Food-Mood Questionnaire Among College Students. LID - 10.3390/ijerph21111509 [doi] LID - 1509 AB - A culturally adapted screening tool for mental health and dietary quality is needed to address the significant challenges in mental health and suboptimal diets among college students. The purpose of this study was to validate the Food-Mood Questionnaire (FMQ), originally developed in English, among Arab college students. Students attending the University of Sharjah were invited to complete the questionnaire (n = 224). Two weeks later, participants completed the same questionnaire again. An exploratory factor analysis revealed three main factors: mental distress, prudent and Western diets. Cronbach's alpha was 0.86, 0.72, and 0.531 for the three factors, respectively. The Intra-Class-Correlation (ICC) for the test-retest reliability ranged from 0.67 to 0.87 (p < 0.001). The findings of this study showed that the Arabic version of the FMQ is a valid and reliable tool and could be used to screen for the mental distress and dietary intake of college students in the Arab world. FAU - Begdache, Lina AU - Begdache L AUID- ORCID: 0000-0001-5213-6979 AD - Health and Wellness Studies Department, Binghamton University, Binghamton, NY 13902, USA. FAU - Radwan, Hadia AU - Radwan H AUID- ORCID: 0000-0002-3930-2554 AD - Department of Clinical Nutrition and Dietetics, Research Institute of Medical and Health Sciences, College of Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates. FAU - Abu Qiyas, Salma AU - Abu Qiyas S AD - Department of Clinical Nutrition and Dietetics, Research Institute of Medical and Health Sciences, College of Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates. FAU - Abbas, Nada AU - Abbas N AD - Department of Clinical Nutrition and Dietetics, Research Institute of Medical and Health Sciences, College of Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates. FAU - Naja, Farah AU - Naja F AD - Department of Clinical Nutrition and Dietetics, Research Institute of Medical and Health Sciences, College of Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates. AD - Nutrition and Food Sciences Department, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon. LA - eng PT - Journal Article PT - Validation Study DEP - 20241113 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Young Adult MH - Arabs MH - Diet MH - Reproducibility of Results MH - *Students/psychology MH - *Surveys and Questionnaires MH - Universities MH - Affect MH - Culture PMC - PMC11594256 OTO - NOTNLM OT - United Arab Emirates OT - food intake OT - mental health OT - validation OT - youth COIS- The authors declare no conflicts of interest. EDAT- 2024/11/27 06:19 MHDA- 2024/11/27 06:20 PMCR- 2024/11/13 CRDT- 2024/11/27 01:19 PHST- 2024/07/16 00:00 [received] PHST- 2024/11/05 00:00 [revised] PHST- 2024/11/11 00:00 [accepted] PHST- 2024/11/27 06:20 [medline] PHST- 2024/11/27 06:19 [pubmed] PHST- 2024/11/27 01:19 [entrez] PHST- 2024/11/13 00:00 [pmc-release] AID - ijerph21111509 [pii] AID - ijerph-21-01509 [pii] AID - 10.3390/ijerph21111509 [doi] PST - epublish SO - Int J Environ Res Public Health. 2024 Nov 13;21(11):1509. doi: 10.3390/ijerph21111509. PMID- 39595702 OWN - NLM STAT- MEDLINE DCOM- 20241127 LR - 20260728 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 21 IP - 11 DP - 2024 Oct 29 TI - The Cardiometabolic Multimorbidity Risk Profile of Females Living in Glendale, ILembe District of Kwa-Zulu Natal. LID - 10.3390/ijerph21111436 [doi] LID - 1436 AB - BACKGROUND: Empirical studies have indicated that cardiometabolic multimorbidity risk profiles are upsurging among the South African population. However, there is a limited number of studies that have been conducted to validate these findings in rural communities. AIM: To study the prevalence of cardiometabolic risk factors of females residing in rural Glendale in the ILembe District, South Africa. METHODS: One hundred females (aged 18-40 years) voluntarily participated in a cross-sectional observational study. All participants completed an ISAK somatotype profiling, and measured their fasting cholesterol, glucose, blood pressure and resting heart rate. RESULTS: Participants' average age, body mass index, stature, and body mass, were 28.34 +/- 7.07 years, 29.5 +/- 8.06 kg/m(2), 157.26 +/- 6.09 cm, and 72.9 +/- 21.12 kg, respectively. The cohort had a mean waist circumference of 94.2 +/- 22.1 cm, hip circumference of 108.4 +/- 20.9 cm, and waist-to-hip ratio of 0.86. Participants' mean heart rate, systolic blood pressure, and diastolic blood pressure were 86.31 +/- 8.68 bpm, 116.79 +/- 16.34 mmHg, and 82.14 +/- 10.87 mmHg, respectively. Eleven participants recorded a resting heart rate greater than 100 bpm. Average blood glucose, total cholesterol, low-density lipoprotein, and high-density lipoprotein recorded were 4.87 +/- 1.26 mmol/L, 3.78 +/- 0.94 mmol/L, 1.76 +/- 1.86 mmol/L, and 1.31 +/- 0.4 mmol/L. Eighty-three participants HDL-C were below the recommended normative value of 1.55 mmol/L. CONCLUSION: The average participant presented as overweight, with elevated diastolic blood pressure, and a resting heart rate that has been proven to increase one's cardiometabolic multimorbidity risk profile. Additionally, a small portion of the cohort were identified to be prediabetic and diabetic. Large proportion of participants had low HDL-C levels suggestive of poor cardiovascular disease protection. FAU - Grobler, Bridget AU - Grobler B AUID- ORCID: 0000-0001-7972-6549 AD - Department of Sport, Rehabilitation & Dental Science, Pretoria West Campus, Tshwane University of Technology, Pretoria 0001, South Africa. FAU - Ellapen, Terry Jeremy AU - Ellapen TJ AUID- ORCID: 0000-0002-3225-7949 AD - Department of Sport, Rehabilitation & Dental Science, Pretoria West Campus, Tshwane University of Technology, Pretoria 0001, South Africa. LA - eng PT - Journal Article PT - Observational Study DEP - 20241029 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 RN - 0 (Blood Glucose) SB - IM MH - Humans MH - Female MH - Adult MH - South Africa/epidemiology MH - *Multimorbidity MH - Young Adult MH - Cross-Sectional Studies MH - Adolescent MH - Cardiometabolic Risk Factors MH - Blood Pressure MH - Risk Factors MH - Prevalence MH - Rural Population/statistics & numerical data MH - Cardiovascular Diseases/epidemiology MH - Heart Rate MH - Blood Glucose/analysis PMC - PMC11593891 OTO - NOTNLM OT - blood pressure OT - cardiometabolic multimorbidity OT - overweight COIS- Upon the time of submission, no author had any conflicts of interest to declare. This manuscript is submitted to this journal alone. EDAT- 2024/11/27 06:19 MHDA- 2024/11/27 06:20 PMCR- 2024/10/29 CRDT- 2024/11/27 01:19 PHST- 2024/09/16 00:00 [received] PHST- 2024/10/23 00:00 [revised] PHST- 2024/10/28 00:00 [accepted] PHST- 2024/11/27 06:20 [medline] PHST- 2024/11/27 06:19 [pubmed] PHST- 2024/11/27 01:19 [entrez] PHST- 2024/10/29 00:00 [pmc-release] AID - ijerph21111436 [pii] AID - ijerph-21-01436 [pii] AID - 10.3390/ijerph21111436 [doi] PST - epublish SO - Int J Environ Res Public Health. 2024 Oct 29;21(11):1436. doi: 10.3390/ijerph21111436. PMID- 39594943 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241128 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 11 IP - 11 DP - 2024 Nov 12 TI - How Family Structure Can Influence Adolescents' Eating Habits: An Italian Health Behaviour in School-Aged Children (HBSC) 2022 Sample. LID - 10.3390/children11111368 [doi] LID - 1368 AB - BACKGROUND/OBJECTIVES: Adolescence is an important period of psychophysical development. In this phase of life people acquire greater self-awareness and adopt behaviors that will later shape their lifestyle in adulthood. This study aimed to assess whether family structure can influence adolescents' eating habits. METHODS: Data were acquired from a survey titled 'Italian Health Behaviour in School-aged Children' (HBSC) given to a representative sample of Tuscan adolescents aged 11, 13, 15 and 17 years of age. Participants (3210) filled out a validated questionnaire answering questions about their eating habits and family structure. After adjusting for covariates, some interesting trends were highlighted in the survey results. RESULTS: Adolescents living in single-mother families reported a lower intake of fruits (OR 0.68, 95% CI = 0.55-0.83) and vegetables (OR 0.66, 95% CI = 0.53-0.81) and a higher intake of sugar-added soft drinks (OR 1.33, 95% CI = 1.08-1.64). Living in a mother and stepfather family was associated with a higher intake of sugar-added soft drinks (OR 1.53, 95% CI = 1.02-2.28), whereas living in a father and stepmother family was associated only with a lower intake of fruits (OR 0.48, 95% CI = 0.26-0.87). Participants living with other family types reported a lower intake of vegetables (OR 0.68, 95% CI = 0.47-0.98). CONCLUSIONS: The results of this study show a correlation between family structure and adolescents' eating habits. FAU - Bocci, Bianca Maria AU - Bocci BM AUID- ORCID: 0009-0006-0334-9832 AD - Post Graduate School of Public Health, University of Siena, 53100 Siena, Italy. FAU - Lipari, Dario AU - Lipari D AUID- ORCID: 0000-0003-1534-2460 AD - Post Graduate School of Public Health, University of Siena, 53100 Siena, Italy. FAU - Pammolli, Andrea AU - Pammolli A AD - Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy. AD - Research Center on Health Prevention and Promotion (CREPS), University of Siena, 53100 Siena, Italy. FAU - Simi, Rita AU - Simi R AD - Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy. AD - Research Center on Health Prevention and Promotion (CREPS), University of Siena, 53100 Siena, Italy. FAU - Frongillo, Elena AU - Frongillo E AD - Post Graduate School of Public Health, University of Siena, 53100 Siena, Italy. FAU - Miserendino, Antonella AU - Miserendino A AD - Post Graduate School of Public Health, University of Siena, 53100 Siena, Italy. FAU - Manini, Ilaria AU - Manini I AUID- ORCID: 0000-0002-5877-3095 AD - Post Graduate School of Public Health, University of Siena, 53100 Siena, Italy. AD - Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy. AD - Interuniversity Research Centre on Influenza and Other Transmissible Infections (CIRI-IT), 16132 Genoa, Italy. FAU - Lazzeri, Giacomo AU - Lazzeri G AUID- ORCID: 0000-0002-9095-7652 AD - Post Graduate School of Public Health, University of Siena, 53100 Siena, Italy. AD - Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy. AD - Research Center on Health Prevention and Promotion (CREPS), University of Siena, 53100 Siena, Italy. AD - Interuniversity Research Centre on Influenza and Other Transmissible Infections (CIRI-IT), 16132 Genoa, Italy. LA - eng PT - Journal Article DEP - 20241112 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC11593287 OTO - NOTNLM OT - Italian Health Behaviour in School-aged Children OT - adolescents OT - eating habits OT - family structure OT - parental influence OT - survey COIS- The authors declare no conflicts of interest. EDAT- 2024/11/27 06:20 MHDA- 2024/11/27 06:21 PMCR- 2024/11/12 CRDT- 2024/11/27 01:14 PHST- 2024/09/26 00:00 [received] PHST- 2024/11/07 00:00 [revised] PHST- 2024/11/07 00:00 [accepted] PHST- 2024/11/27 06:21 [medline] PHST- 2024/11/27 06:20 [pubmed] PHST- 2024/11/27 01:14 [entrez] PHST- 2024/11/12 00:00 [pmc-release] AID - children11111368 [pii] AID - children-11-01368 [pii] AID - 10.3390/children11111368 [doi] PST - epublish SO - Children (Basel). 2024 Nov 12;11(11):1368. doi: 10.3390/children11111368. PMID- 39593610 OWN - NLM STAT- MEDLINE DCOM- 20241127 LR - 20260404 IS - 1532-9283 (Electronic) IS - 1360-8592 (Linking) VI - 40 DP - 2024 Oct TI - Association between Body Mass Index (BMI) and waist circumference with leg power in cricketers. PG - 356-359 LID - S1360-8592(24)00225-0 [pii] LID - 10.1016/j.jbmt.2024.04.037 [doi] AB - Cricket is one of the most well-known sports played in India. It not only comprises of aerobic activity but also includes complex-based movements like running, jumping, diving, catching, etc that depend on various individual factors such as height, weight, power, endurance, agility etc. OBJECTIVES: The purpose of the study was to determine the relationship between BMI, Waist circumference with leg power in cricket players. DESIGN: The study was a cross-sectional assessment-based study. SETTING: Players from different clubs and associations were included. PARTICIPANTS: 43 male and female cricketers from both recreational and professional backgrounds, between the age group of 16-25 years were included in the study. MAIN OUTCOME MEASURES: Participants were included according to the inclusion and exclusion criteria using validated screening tools and assessment protocols. The BMI, and WC using a weighing scale and measuring tape respectively, and leg power was measured using the vertical jump test which is a commonly used tool to measure an athlete's ability to explosively drive themselves off the ground in a vertical direction, providing insight into the strength and power generated by the lower muscles. RESULTS: A significant negative correlation was found between Waist circumference and Leg power with r value of -0.338 with p = 0.023. While a significant but weak negative correlation was found between BMI and Leg power with r value of -0.279 with p = 0.070. CONCLUSION: Present study concluded that waist circumference has a significant negative correlation with leg power than BMI in cricketers. CI - Copyright (c) 2024 Elsevier Ltd. All rights reserved. FAU - Chorge, Aishwarya AU - Chorge A AD - D Y Patil University, School of Physiotherapy, Sector 7, Nerul, Navi Mumbai, 400706, India. FAU - Pol, Titiksha AU - Pol T AD - D Y Patil University, School of Physiotherapy, Sector 7, Nerul, Navi Mumbai, 400706, India. Electronic address: titikshapolphysio@gmail.com. LA - eng PT - Journal Article DEP - 20240418 PL - United States TA - J Bodyw Mov Ther JT - Journal of bodywork and movement therapies JID - 9700068 SB - IM MH - Humans MH - Male MH - *Waist Circumference/physiology MH - Female MH - *Body Mass Index MH - Cross-Sectional Studies MH - Adult MH - Young Adult MH - Adolescent MH - *Muscle Strength/physiology MH - *Cricket Sport/physiology MH - Leg/physiology MH - India OTO - NOTNLM OT - Anthropometric measures OT - Cricket OT - Obesity OT - Power OT - Sports OT - Vertical jump test COIS- Declaration of competing interest None declared EDAT- 2024/11/27 06:19 MHDA- 2024/11/27 06:20 CRDT- 2024/11/27 01:04 PHST- 2022/06/19 00:00 [received] PHST- 2024/04/09 00:00 [revised] PHST- 2024/04/11 00:00 [accepted] PHST- 2024/11/27 06:20 [medline] PHST- 2024/11/27 06:19 [pubmed] PHST- 2024/11/27 01:04 [entrez] AID - S1360-8592(24)00225-0 [pii] AID - 10.1016/j.jbmt.2024.04.037 [doi] PST - ppublish SO - J Bodyw Mov Ther. 2024 Oct;40:356-359. doi: 10.1016/j.jbmt.2024.04.037. Epub 2024 Apr 18. PMID- 39590917 OWN - NLM STAT- MEDLINE DCOM- 20250426 LR - 20250910 IS - 1533-4287 (Electronic) IS - 1064-8011 (Linking) VI - 39 IP - 4 DP - 2025 Apr 1 TI - Estimation of Whole-Body Bone Mineral Density Through Air Displacement Plethysmography in a Large Sample of Elite Athletes. PG - 427-432 LID - 10.1519/JSC.0000000000005024 [doi] AB - Magee, MK, Fields, JB, Jagim, A, Lockard, B, Miller, A, Stroiney, D, and Jones, MT. Estimation of whole-body bone mineral density through air displacement plethysmography in a large sample of elite athletes. J Strength Cond Res 39(4): 427-432, 2025-Dual-energy x-ray absorptiometry (DXA) is used to determine bone mineral density (BMD) and body composition. Regulations and cost may limit DXA's utility in some athletic settings. Air displacement plethysmography (ADP), while able to measure body composition, does not measure BMD. The purpose was to evaluate the influence of body composition parameters obtained from ADP on BMD. Collegiate athletes (males, n = 153; females, n = 208) underwent ADP and DXA assessments. For ADP testing, the Brozek equation was used to estimate body fat percent (BF%) and fat-free mass (FFM) from body density. Dual-energy x-ray absorptiometry tests were completed to obtain BMD using the whole-body scan mode. Stepwise regression was conducted using age, body mass, height, sex, race, FFM (ADP), BF% (ADP), and sport type as independent variables. Total BMD (DXA) was the dependent variable. Accuracy and precision of the final equation were evaluated through Bland-Altman and linear regression. The final regression equation yielded an R2 of 0.691 with race, mass, BF%, age, and sport type as significant predictors ( p < 0.05) of BMD. Bland-Altman and linear regression showed systematic 95% confidence interval [CI] (-0.619 to -0.360) and proportional bias (95% CI [0.173-0.374]). Although an ADP-derived regression equation may not provide a precise prediction of BMD, it may be useful to establish risk for low BMD if DXA is unavailable. Dual-energy x-ray absorptiometry may not be feasible for some athletic programs; therefore, an estimation equation for BMD derived from ADP values is advantageous for practitioners. This equation may assist in screening athletes for risk of low BMD. CI - Copyright (c) 2024 National Strength and Conditioning Association. FAU - Magee, Meghan K AU - Magee MK AD - Exercise Science and Exercise Physiology, Kent State University, Kent, Ohio. AD - Patriot Performance Laboratory, Frank Pettrone Center for Sports Performance, Intercollegiate Athletics, George Mason University, Fairfax, Virginia. FAU - Fields, Jennifer B AU - Fields JB AD - Patriot Performance Laboratory, Frank Pettrone Center for Sports Performance, Intercollegiate Athletics, George Mason University, Fairfax, Virginia. AD - Nutritional Sciences, University of Connecticut, Storrs, Connecticut. FAU - Jagim, Andrew AU - Jagim A AD - Patriot Performance Laboratory, Frank Pettrone Center for Sports Performance, Intercollegiate Athletics, George Mason University, Fairfax, Virginia. AD - Sports Medicine, Mayo Clinic Health System, La Crosse, Wisconsin. FAU - Lockard, Brittanie AU - Lockard B AD - Patriot Performance Laboratory, Frank Pettrone Center for Sports Performance, Intercollegiate Athletics, George Mason University, Fairfax, Virginia. AD - Division of Human Performance, University of the Incarnate Word, San Antonio, Texas. FAU - Miller, Angela AU - Miller A AD - Research Methods and Educational Psychology, George Mason University, Fairfax, Virginia; and. FAU - Stroiney, Debra AU - Stroiney D AD - Exercise Science and Exercise Physiology, Kent State University, Kent, Ohio. FAU - Jones, Margaret T AU - Jones MT AUID- ORCID: 0000-0003-3940-7396 AD - Patriot Performance Laboratory, Frank Pettrone Center for Sports Performance, Intercollegiate Athletics, George Mason University, Fairfax, Virginia. AD - Sport, Recreation, and Tourism Management, George Mason University, Manassas, Virginia 22030. LA - eng PT - Journal Article DEP - 20241126 PL - United States TA - J Strength Cond Res JT - Journal of strength and conditioning research JID - 9415084 SB - IM MH - Humans MH - *Bone Density MH - Female MH - Absorptiometry, Photon MH - Male MH - Young Adult MH - *Athletes MH - Body Composition MH - Adult MH - Adolescent MH - *Plethysmography, Whole Body/methods MH - *Plethysmography/methods EDAT- 2024/11/26 18:23 MHDA- 2025/03/28 18:25 CRDT- 2024/11/26 13:13 PHST- 2025/03/28 18:25 [medline] PHST- 2024/11/26 18:23 [pubmed] PHST- 2024/11/26 13:13 [entrez] AID - 00124278-202504000-00005 [pii] AID - 10.1519/JSC.0000000000005024 [doi] PST - ppublish SO - J Strength Cond Res. 2025 Apr 1;39(4):427-432. doi: 10.1519/JSC.0000000000005024. Epub 2024 Nov 26. PMID- 39589875 OWN - NLM STAT- MEDLINE DCOM- 20241126 LR - 20260724 IS - 1091-6490 (Electronic) IS - 0027-8424 (Print) IS - 0027-8424 (Linking) VI - 121 IP - 49 DP - 2024 Dec 3 TI - Using the phenotype differences model to identify genetic effects in samples of partially genotyped sibling pairs. PG - e2405725121 LID - 10.1073/pnas.2405725121 [doi] LID - e2405725121 AB - The identification of causal relationships between specific genes and social, behavioral, and health outcomes is challenging due to environmental confounding from population stratification and dynastic genetic effects. Existing methods to eliminate environmental confounding leverage random genetic variation resulting from recombination and require within-family dyadic genetic data (i.e., parent-child and/or sibling pairs), meaning they can only be applied in relatively small and selected samples. We introduce the phenotype differences model and provide derivations showing that it-under plausible assumptions-provides consistent (and, in certain cases, unbiased) estimates of genetic effects using just a single individual's genotype. Then, leveraging distinct samples of fully and partially genotyped sibling pairs in the Wisconsin Longitudinal Study, we use polygenic indices and phenotypic data for 24 different traits to empirically validate the phenotype differences model. Finally, we utilize the model to test the effects of 40 polygenic indices on lifespan. After a 10% false discovery rate correction, we find that polygenic indices for three traits-body mass index, self-rated health, chronic obstructive pulmonary disease-have a statistically significant effect on an individual's lifespan. FAU - Trejo, Sam AU - Trejo S AUID- ORCID: 0000-0002-9880-5354 AD - Department of Sociology and Office of Population Research, Princeton University, Princeton, NJ 08544. FAU - Kanopka, Klint AU - Kanopka K AUID- ORCID: 0000-0003-3196-9538 AD - Steinhardt School of Culture, Education, and Human Development, Department of Applied Statistics, Social Science, and Humanities, New York University, New York, NY 10003. LA - eng GR - R305B140009/Institute for Education Sciences/ PT - Journal Article DEP - 20241126 PL - United States TA - Proc Natl Acad Sci U S A JT - Proceedings of the National Academy of Sciences of the United States of America JID - 7505876 SB - IM MH - Humans MH - *Siblings MH - *Phenotype MH - *Multifactorial Inheritance/genetics MH - *Models, Genetic MH - *Genotype MH - Male MH - Female MH - Longitudinal Studies MH - Body Mass Index MH - Longevity/genetics PMC - PMC11626128 OTO - NOTNLM OT - biodemography OT - causal inference OT - genomics OT - premature mortality OT - quantitative methods COIS- Competing interests statement:The authors declare no competing interest. EDAT- 2024/11/26 18:23 MHDA- 2024/11/26 18:24 PMCR- 2025/05/26 CRDT- 2024/11/26 12:23 PHST- 2024/11/26 18:24 [medline] PHST- 2024/11/26 18:23 [pubmed] PHST- 2024/11/26 12:23 [entrez] PHST- 2025/05/26 00:00 [pmc-release] AID - 202405725 [pii] AID - 10.1073/pnas.2405725121 [doi] PST - ppublish SO - Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2405725121. doi: 10.1073/pnas.2405725121. Epub 2024 Nov 26. PMID- 39585850 OWN - NLM STAT- MEDLINE DCOM- 20241125 LR - 20260902 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 11 DP - 2024 TI - Assessment of the psychometric properties of the eHealth Literacy Scale for Brazilian adolescents. PG - e0314099 LID - 10.1371/journal.pone.0314099 [doi] LID - e0314099 AB - With the increase in digitalization of adolescents and health services, the population must demonstrate digital health literacy skills to be able to navigate online health information, as well as identify, evaluate, and apply relevant information. The present study aimed to investigate the psychometric properties of the adapted version of the eHealth Literacy Scale (eHEALS-BrA) for Brazilian adolescents. This study was conducted between September 2022 and May 2023, involving a total of 260 adolescents aged 13 to 19, with a mean age of 15.64 years (SD = 1.84), all of whom were enrolled in public schools in Brazil. Structural validity was evaluated by confirmatory factor analysis (CFA). The reliability of the instrument was assessed using Cronbach's alpha (alpha) and McDonald's omega (omega), and test-retest reliability. Questionnaires about sociodemographic aspects, health-related characteristics, and internet use were administered and used as discriminant validation measures. Convergent Validity was determined by correction with the domains of the World Health Organization Quality of Life-Bref (WHOQOL-Bref) instrument. For test-retest reliability, 67 participants completed the eHEALS-BrA a fortnight later. The average eHEALS-BrA score was 28.05 points (SD = 5.05). CFA revealed that the model with the best fit had a single factor (chi2 = 49.884 [df = 20, p = 0.0002], CFI = 0.934, TLI = 0.908, RMSEA = 0.076(CI:0.05-0.10), and SRMR = 0.045). The instrument demonstrated good reliability, with satisfactory internal consistency (alpha and omega = 0.71) and stability (ICC = 0.82, 95% CI:0.70-0.89). The eHEALS-BrA was correlated with the physical, psychological, and environmental domains of the WHOQOL-Bref (p = 0.001) (convergent validity). Higher scores were found among male adolescents, individuals who practiced physical activity, those with better self-rated health, those who considered the internet useful for searching for health information (discriminant validity), and those with better self-rated skills related to using the internet (convergent validity) (p < 0.05). The eHEALS-BrA demonstrated adequate psychometric properties for measuring digital health literacy in Brazilian adolescents. CI - Copyright: (c) 2024 Barbosa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Barbosa, Mariane Carolina Faria AU - Barbosa MCF AUID- ORCID: 0000-0002-2870-8364 AD - Department of Pediatric Dentistry, Federal University of Minas Gerais (UFMG), Belo Horizonte, (MG), Brazil. FAU - Baldiotti, Ana Luiza Peres AU - Baldiotti ALP AD - Department of Pediatric Dentistry, Federal University of Minas Gerais (UFMG), Belo Horizonte, (MG), Brazil. FAU - Resende, Julia Lara AU - Resende JL AD - Department of Pediatric Dentistry, Federal University of Minas Gerais (UFMG), Belo Horizonte, (MG), Brazil. FAU - Perazzo, Matheus de Franca AU - Perazzo MF AD - Postgraduate Program in Dentistry, Federal University of Goias (UFG), Goiania, (GO), Brazil. FAU - Firmino, Ramon Targino AU - Firmino RT AD - Postgraduate Program in Dentistry, Federal University of Campina Grande (UFCG), Campina Grande, (PB), Brazil. FAU - Granville-Garcia, Ana Flavia AU - Granville-Garcia AF AD - Postgraduate Program in Dentistry, State University of Paraiba (UEPB), Campina Grande, (PB), Brazil. FAU - Paiva, Saul Martins AU - Paiva SM AD - Department of Pediatric Dentistry, Federal University of Minas Gerais (UFMG), Belo Horizonte, (MG), Brazil. FAU - Ferreira, Fernanda de Morais AU - Ferreira FM AUID- ORCID: 0000-0001-9400-1167 AD - Department of Pediatric Dentistry, Federal University of Minas Gerais (UFMG), Belo Horizonte, (MG), Brazil. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241125 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Adolescent MH - Brazil MH - Male MH - Female MH - *Psychometrics/methods MH - *Health Literacy MH - *Telemedicine MH - Surveys and Questionnaires MH - Reproducibility of Results MH - Young Adult MH - Quality of Life PMC - PMC11588242 COIS- The authors have declared that no competing interests exist. EDAT- 2024/11/25 18:27 MHDA- 2024/11/25 18:28 PMCR- 2024/11/25 CRDT- 2024/11/25 13:43 PHST- 2024/07/02 00:00 [received] PHST- 2024/11/06 00:00 [accepted] PHST- 2024/11/25 18:28 [medline] PHST- 2024/11/25 18:27 [pubmed] PHST- 2024/11/25 13:43 [entrez] PHST- 2024/11/25 00:00 [pmc-release] AID - PONE-D-24-26118 [pii] AID - 10.1371/journal.pone.0314099 [doi] PST - epublish SO - PLoS One. 2024 Nov 25;19(11):e0314099. doi: 10.1371/journal.pone.0314099. eCollection 2024. PMID- 39584889 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241127 IS - 2411-5142 (Electronic) IS - 2411-5142 (Linking) VI - 9 IP - 4 DP - 2024 Nov 14 TI - The Impact of Digital Devices on Children's Health: A Systematic Literature Review. LID - 10.3390/jfmk9040236 [doi] LID - 236 AB - BACKGROUND: The impact of prolonged digital device exposure on physical and mental health in children has been widely investigated by the scientific community. Additionally, the lockdown periods due to the COVID-19 pandemic further exposed children to screen time for e-learning activities. The aim of this systematic review (PROSPERO Registration: CRD42022315596) was to evaluate the effect of digital device exposure on children's health. The impact of the COVID-19 pandemic was additionally explored to verify the further exposure of children due to the e-learning environment. METHODS: Available online databases (PubMed, Google Scholar, Semantic Scholar, BASE, Scopus, Web of Science, and SPORTDiscus) were searched for study selection. The PICO model was followed by including a target population of children aged 2 to 12 years, exposed or not to any type of digital devices, while evaluating changes in both physical and mental health outcomes. The quality assessment was conducted by using the Joanna Briggs Institute (JBI) Critical Appraisal Tool. Synthesis without meta-analysis (SWiM) guidelines were followed to provide data synthesis. RESULTS: Forty studies with a total sample of 75,540 children were included in this systematic review. The study design was mainly cross-sectional (n = 28) and of moderate quality (n = 33). Overall, the quality score was reduced due to recall, selection, and detection biases; blinding procedures influenced the quality score of controlled trials, and outcome validity reduced the quality score of cohort studies. Digital device exposure affected physical activity engagement and adiposity parameters; sleep and behavioral problems emerged in children overexposed to digital devices. Ocular conditions were also reported and associated with higher screen exposure. Home confinement during COVID-19 further increased digital device exposure with additional negative effects. CONCLUSIONS: The prolonged use of digital devices has a significant negative impact on children aged 2 to 12, leading to decreased physical activity, sleep disturbances, behavioral issues, lower academic performance, socioemotional challenges, and eye strain, particularly following extended online learning during lockdowns. FAU - Presta, Valentina AU - Presta V AUID- ORCID: 0000-0003-0820-9135 AD - Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126 Parma, Italy. FAU - Guarnieri, Alessandro AU - Guarnieri A AUID- ORCID: 0000-0003-1238-8172 AD - Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126 Parma, Italy. FAU - Laurenti, Fabiana AU - Laurenti F AD - Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126 Parma, Italy. AD - Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Piazzale Ludovico Antonio Scuro 10, 37124 Verona, Italy. FAU - Mazzei, Salvatore AU - Mazzei S AUID- ORCID: 0009-0001-3021-4718 AD - Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126 Parma, Italy. FAU - Arcari, Maria Luisa AU - Arcari ML AD - Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126 Parma, Italy. FAU - Mirandola, Prisco AU - Mirandola P AD - Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126 Parma, Italy. FAU - Vitale, Marco AU - Vitale M AD - Faculty of Medicine and Surgery, University Vita-Salute San Raffaele, Via Olgettina 58, 20132 Milan, Italy. FAU - Chia, Michael Yong Hwa AU - Chia MYH AUID- ORCID: 0000-0002-1289-0552 AD - Physical Education and Sports Science Academic Department, National Institute of Education, Nanyang Technological University, 1 Nanyang Walk, Singapore 637616, Singapore. FAU - Condello, Giancarlo AU - Condello G AUID- ORCID: 0000-0001-5092-3258 AD - Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126 Parma, Italy. FAU - Gobbi, Giuliana AU - Gobbi G AUID- ORCID: 0000-0003-1197-3484 AD - Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126 Parma, Italy. LA - eng PT - Journal Article PT - Review DEP - 20241114 PL - Switzerland TA - J Funct Morphol Kinesiol JT - Journal of functional morphology and kinesiology JID - 101712257 PMC - PMC11587142 OTO - NOTNLM OT - body composition OT - coronavirus OT - physical activity OT - screen time OT - sleep disturbances COIS- The authors declare no conflicts of interest. EDAT- 2024/11/25 12:32 MHDA- 2024/11/25 12:33 PMCR- 2024/11/14 CRDT- 2024/11/25 09:13 PHST- 2024/10/13 00:00 [received] PHST- 2024/11/07 00:00 [revised] PHST- 2024/11/12 00:00 [accepted] PHST- 2024/11/25 12:33 [medline] PHST- 2024/11/25 12:32 [pubmed] PHST- 2024/11/25 09:13 [entrez] PHST- 2024/11/14 00:00 [pmc-release] AID - jfmk9040236 [pii] AID - jfmk-09-00236 [pii] AID - 10.3390/jfmk9040236 [doi] PST - epublish SO - J Funct Morphol Kinesiol. 2024 Nov 14;9(4):236. doi: 10.3390/jfmk9040236. PMID- 39584781 OWN - NLM STAT- MEDLINE DCOM- 20250426 LR - 20260819 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 21 IP - 2 DP - 2025 Apr TI - Feeding Practices Used by Australian Parents of Young Children Living With Food Insecurity and Household Chaos. PG - e13770 LID - 10.1111/mcn.13770 [doi] LID - e13770 AB - Responsive feeding practices are crucial for developing healthy eating behaviours in children. However, chaotic households and financial stress may disrupt these practices. This cross-sectional study aimed to characterise feeding practices among Australian parents experiencing financial hardship. Parents of children aged 5-35 months, who identified as experiencing financial hardship, completed an online questionnaire from October 2021 to June 2022. Validated tools gathered data on feeding practices, mealtime structure and environment, household chaos (HC), household food insecurity (HFI) and sociodemographic characteristics. Bivariate correlations and hierarchical regression assessed relationships between these variables, adjusted for parent age, education and number of children. Data from 213 parent-child dyads were analysed (97% mothers, median age = 31 years, IQR 28-36; 50% boys, median age = 12 months, IQR 8-17). Median HC score was 4 (IQR 2-7). Seventy-six percent of families reported experiencing HFI (median = 6, IQR 3-9). Over 80% of parents often or always ate meals as a family and never or rarely engaged in 'parent-led' feeding (median = 1.75, IQR 1.00-2.50), or used '(non)-food as reward' (median = 1.33, IQR 1.00-2.00). '(Non)-food as reward' was positively correlated with HC (p = 0.016), and 'food to calm' was positively associated with HC (p = 0.004). 'Feeding on demand' was negatively associated with HC and HFI (p = 0.002). 'Persuasive feeding' was not associated with either. Findings suggest that HC had more influence than HFI on some nonresponsive feeding practices. Increasing levels of HC and HFI may result in less structured mealtimes. Interventions must consider how financial hardship, HFI and HC can impact parents' ability to engage in responsive feeding practices. This cross-sectional study examined feeding practices among Australian parents facing financial hardship. Over 75% were food insecure. While the meal environment supported responsive feeding, increasing household chaos and food insecurity led to fewer structured mealtimes and household chaos increased coercive practices such as using (non)-food rewards and food to calm. CI - (c) 2024 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Nambiar, Smita AU - Nambiar S AUID- ORCID: 0000-0002-0626-1119 AD - School of Exercise and Nutrition Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, Brisbane, Queensland, Australia. AD - Centre for Child Nutrition Research, Faculty of Health, Queensland University of Technology, South Brisbane, Queensland, Australia. FAU - Stanley, Lauren AU - Stanley L AD - School of Exercise and Nutrition Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, Brisbane, Queensland, Australia. FAU - Miller, Lily AU - Miller L AD - School of Exercise and Nutrition Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, Brisbane, Queensland, Australia. FAU - Byrne, Rebecca A AU - Byrne RA AUID- ORCID: 0000-0002-0096-3320 AD - School of Exercise and Nutrition Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, Brisbane, Queensland, Australia. AD - Centre for Child Nutrition Research, Faculty of Health, Queensland University of Technology, South Brisbane, Queensland, Australia. FAU - Gallegos, Danielle AU - Gallegos D AUID- ORCID: 0000-0001-5901-1909 AD - School of Exercise and Nutrition Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, Brisbane, Queensland, Australia. AD - Centre for Child Nutrition Research, Faculty of Health, Queensland University of Technology, South Brisbane, Queensland, Australia. FAU - Penny, Robyn A AU - Penny RA AUID- ORCID: 0000-0002-5002-8998 AD - Child Health Liaison, Children's Health Queensland Hospital and Health Service, Brisbane, Queensland, Australia. FAU - Baxter, Kimberley A AU - Baxter KA AUID- ORCID: 0000-0001-5180-1455 AD - Centre for Child Nutrition Research, Faculty of Health, Queensland University of Technology, South Brisbane, Queensland, Australia. LA - eng PT - Journal Article DEP - 20241125 PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - Male MH - Female MH - Cross-Sectional Studies MH - *Food Insecurity MH - Australia MH - Adult MH - *Feeding Behavior/psychology MH - Child, Preschool MH - *Family Characteristics MH - Infant MH - *Parents/psychology MH - Surveys and Questionnaires MH - Meals MH - Socioeconomic Factors PMC - PMC11956056 OTO - NOTNLM OT - child OT - food insecurity OT - household chaos OT - responsive feeding COIS- The authors declare no conflicts of interest. EDAT- 2024/11/25 12:32 MHDA- 2025/03/31 21:16 PMCR- 2024/11/25 CRDT- 2024/11/25 08:34 PHST- 2024/10/29 00:00 [revised] PHST- 2024/05/22 00:00 [received] PHST- 2024/11/05 00:00 [accepted] PHST- 2025/03/31 21:16 [medline] PHST- 2024/11/25 12:32 [pubmed] PHST- 2024/11/25 08:34 [entrez] PHST- 2024/11/25 00:00 [pmc-release] AID - MCN13770 [pii] AID - 10.1111/mcn.13770 [doi] PST - ppublish SO - Matern Child Nutr. 2025 Apr;21(2):e13770. doi: 10.1111/mcn.13770. Epub 2024 Nov 25. PMID- 39584657 OWN - NLM STAT- MEDLINE DCOM- 20241211 LR - 20260407 IS - 1564-8265 (Electronic) IS - 0379-5721 (Print) IS - 0379-5721 (Linking) VI - 45 IP - 4 DP - 2024 Dec TI - Development and Validation of the South African Diet Quality Index for Pregnancy: The NuEMI Study. PG - 164-176 LID - 10.1177/03795721241298377 [doi] AB - BACKGROUND: Diet quality indexes (DQIs) consist of combinations of foods and/or nutrient components that represent adherence to dietary guidelines. A high-quality diet during pregnancy contributes to optimal birth outcomes. OBJECTIVE: We developed and validated the first DQI for pregnancy for South African women. METHODS: The South African Food Based Dietary Guidelines and pregnancy dietary guidelines were used as theoretical basis for the a priori development of the South African Diet Quality Index for Pregnancy (SA-DQI-P). To validate the SA-DQI-P, we applied it to data collected for the Nutritional status of Expectant Mothers and their newborn Infants (NuEMI) study (N = 682). We determined the associations between SA-DQI-P scores in tertiles with nutrient intakes, sociodemographic factors, household food security level, and biochemical values. RESULTS: A lower household density ratio, household access to a toilet, refrigerator, and microwave, a higher educational level, being employed and being food secure were significantly associated with a higher score. After correcting for energy intake, higher scores were significantly associated with higher intakes of protein, total fat, saturated fat, cholesterol, calcium, vitamin A, vitamin E, folic acid, vitamin B12, and vitamin C. Significantly more participants who were vitamin A deficient scored in the lowest tertile than those in higher tertiles. CONCLUSION: The SA-DQI-P is the first DQI developed for a South African population and has proven to be valid in ranking diet quality in pregnant women in our sample. Information regarding diet quality of this vulnerable group can assist with planning nutrition intervention programs to improve nutritional status. FAU - Robb, Liska AU - Robb L AUID- ORCID: 0000-0002-3312-8436 AD - Department of Nutrition and Dietetics, University of the Free State, Bloemfontein, Republic of South Africa. FAU - Joubert, Gina AU - Joubert G AD - Department of Biostatistics, University of the Free State, Bloemfontein, Republic of South Africa. FAU - Jordaan, Elizabeth Margaretha AU - Jordaan EM AD - Department of Nutrition and Dietetics, University of the Free State, Bloemfontein, Republic of South Africa. FAU - Ngounda, Jennifer AU - Ngounda J AD - Department of Nutrition and Dietetics, University of the Free State, Bloemfontein, Republic of South Africa. FAU - van den Berg, Louise AU - van den Berg L AD - Department of Nutrition and Dietetics, University of the Free State, Bloemfontein, Republic of South Africa. FAU - Walsh, Corinna May AU - Walsh CM AD - Department of Nutrition and Dietetics, University of the Free State, Bloemfontein, Republic of South Africa. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20241125 PL - United States TA - Food Nutr Bull JT - Food and nutrition bulletin JID - 7906418 SB - IM MH - Humans MH - Female MH - Pregnancy MH - South Africa MH - Adult MH - *Nutrition Policy MH - *Diet/statistics & numerical data/standards/methods MH - Nutritional Status MH - Young Adult MH - Maternal Nutritional Physiological Phenomena PMC - PMC11633080 OTO - NOTNLM OT - South Africa OT - diet quality OT - diet quality index OT - maternal nutrition OT - nutrition assessment OT - pregnancy COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2024/11/25 12:31 MHDA- 2024/12/11 06:24 PMCR- 2024/12/11 CRDT- 2024/11/25 07:53 PHST- 2024/12/11 06:24 [medline] PHST- 2024/11/25 12:31 [pubmed] PHST- 2024/11/25 07:53 [entrez] PHST- 2024/12/11 00:00 [pmc-release] AID - 10.1177_03795721241298377 [pii] AID - 10.1177/03795721241298377 [doi] PST - ppublish SO - Food Nutr Bull. 2024 Dec;45(4):164-176. doi: 10.1177/03795721241298377. Epub 2024 Nov 25. PMID- 39584272 OWN - NLM STAT- MEDLINE DCOM- 20241125 LR - 20250603 IS - 1548-6869 (Electronic) IS - 1049-2089 (Linking) VI - 35 IP - 4S DP - 2024 TI - Addressing Food Insecurity During the COVID-19 Pandemic: An Academic Research Group's Response to a Major Social Determinant of Health. PG - 186-195 LID - 10.1353/hpu.2024.a942876 [doi] AB - We developed and implemented a novel food assistance intervention to address rapidly increasing food insecurity during COVID-19. Parents of children from underserved schools enrolled in our National Institutes of Health-funded research participated in a food security needs assessment survey. The tool used validated instruments to assess household food security status and barriers to accessing food assistance. The intervention provided a resource information sheet or direct home food deliveries. We evaluated the intervention using a quasi-experimental design, with baseline serving as the control. One hundred and ninety (190) parents participated. Of the completed responses, 46.0% were food-insecure, 41.0% faced one or more barriers, and 17.9% families qualified for home deliveries. Post-intervention, 72.4% of high-needs families reported deliveries helped "to a great extent"; 29.6% reported no remaining barriers (p<.005, Fischer's exact test). Implementation of a novel food security research tool and two-level food assistance intervention was feasible, highlighting the role community-based researchers can serve in supporting research participants' emerging needs as they become evident. FAU - Drucker, Gabriela AU - Drucker G FAU - Rausch, John AU - Rausch J FAU - Swierad, Ewelina AU - Swierad E FAU - Sawyer, Vanessa AU - Sawyer V FAU - Noble, James M AU - Noble JM FAU - Gazdick, Rachael AU - Gazdick R FAU - Rosa, Marisol De La AU - Rosa M FAU - Eimicke, Joseph AU - Eimicke J FAU - Williams, Olajide AU - Williams O LA - eng PT - Journal Article PL - United States TA - J Health Care Poor Underserved JT - Journal of health care for the poor and underserved JID - 9103800 SB - IM MH - Humans MH - *Food Insecurity MH - *COVID-19/epidemiology/prevention & control MH - *Food Assistance/statistics & numerical data/organization & administration MH - *Social Determinants of Health MH - Female MH - Male MH - United States/epidemiology MH - Adult MH - Child MH - Needs Assessment MH - Parents/psychology MH - Food Supply/statistics & numerical data EDAT- 2024/11/25 11:33 MHDA- 2024/11/25 11:34 CRDT- 2024/11/25 05:27 PHST- 2024/11/25 11:34 [medline] PHST- 2024/11/25 11:33 [pubmed] PHST- 2024/11/25 05:27 [entrez] AID - S1548686924400107 [pii] AID - 10.1353/hpu.2024.a942876 [doi] PST - ppublish SO - J Health Care Poor Underserved. 2024;35(4S):186-195. doi: 10.1353/hpu.2024.a942876. PMID- 39584193 OWN - NLM STAT- MEDLINE DCOM- 20241226 LR - 20260527 IS - 1520-6300 (Electronic) IS - 1042-0533 (Linking) VI - 37 IP - 1 DP - 2025 Jan TI - Enhancement of a Mathematical Model for Predicting Puberty Stage in Boys: A Cross-Sectional Study. PG - e24193 LID - 10.1002/ajhb.24193 [doi] AB - BACKGROUND: Previously, we developed a mathematical model capable of predicting pubertal development (PD) through seven anthropometric variables, with an accuracy of 75%. We believe that it is possible to develop a similar model that uses fewer anthropometric measurements and provides greater precision. OBJECTIVE: Develop a mathematical model capable of predicting PD through anthropometric variables. METHODS: We evaluated the anthropometric profile and PD by medical analysis in 203 boys (Age = 12.6 +/- 2.6). Subsequently, we divided the boys into groups: development (n = 121) and cross-validation (n = 82). Data from the development group were subjected to discriminant analysis to identify which anthropometric indicators would be potential predictors of PD. We subsequently developed an equation based on the indicated indicators and tested its validation using data from the cross-validation group. RESULTS: Discriminant analyses showed that age and sitting-height were the variables with the greatest power to predict PD (p < 0.05). Consequently, the mathematical model was developed: Puberty-score = -17.357 + (0.603 x Age [years]) + (0.127 x Sitting-height [cm]). Based on the scores generated, we classified PD into stage-I (score 3.410). No differences were found between PD assessments performed by doctors and assessments using the mathematical model (p > 0.5). The prediction model showed high agreement (R (2) = 0.867; CCC = 0.899; ICC = 0.900; Kappa = 0.922; alpha-Krippendorff = 0.885; Bland-Altman LoAs = -2.0, 2.0; pure error = 0.0009) with accuracy of 82.8% and precision of 82%. Analyses in the cross-validation group confirmed the reliability of the prediction model. CONCLUSION: The developed mathematical model presents high reliability, validity and accuracy and precision above 80% for determining PD in boys. CI - (c) 2024 Wiley Periodicals LLC. FAU - de Almeida-Neto, Paulo Francisco AU - de Almeida-Neto PF AUID- ORCID: 0000-0002-2860-2260 AD - Health Sciences Center, Federal University of Rio Grande do Norte, UFRN, Natal, RN, Brazil. AD - Department of Physical Education, Federal University of Rio Grande do Norte, UFRN, Natal, RN, Brazil. FAU - Baxter-Jones, Adam Dominic George AU - Baxter-Jones ADG AUID- ORCID: 0000-0003-0430-0556 AD - College of Kinesiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. FAU - Arrais, Ricardo Fernando AU - Arrais RF AUID- ORCID: 0000-0002-9258-4263 AD - Health Sciences Center, Federal University of Rio Grande do Norte, UFRN, Natal, RN, Brazil. AD - Onofre Lopes University Hospital, Federal University of Rio Grande do Norte, UFRN, Natal, RN, Brazil. AD - Pediatrics Department, Federal University of Rio Grande do Norte, UFRN, Natal, RN, Brazil. FAU - de Azevedo, Jenner Christian Verissimo AU - de Azevedo JCV AD - Onofre Lopes University Hospital, Federal University of Rio Grande do Norte, UFRN, Natal, RN, Brazil. FAU - Dantas, Paulo Moreira Silva AU - Dantas PMS AUID- ORCID: 0000-0002-9217-7107 AD - Health Sciences Center, Federal University of Rio Grande do Norte, UFRN, Natal, RN, Brazil. AD - Department of Physical Education, Federal University of Rio Grande do Norte, UFRN, Natal, RN, Brazil. FAU - Cabral, Breno Guilherme de Araujo Tinoco AU - Cabral BGAT AUID- ORCID: 0000-0002-9966-9956 AD - Health Sciences Center, Federal University of Rio Grande do Norte, UFRN, Natal, RN, Brazil. AD - Department of Physical Education, Federal University of Rio Grande do Norte, UFRN, Natal, RN, Brazil. FAU - Medeiros, Radames Maciel Vitor AU - Medeiros RMV AUID- ORCID: 0000-0003-0811-2851 AD - Health Sciences Center, Federal University of Rio Grande do Norte, UFRN, Natal, RN, Brazil. AD - Department of Physical Education, Federal University of Rio Grande do Norte, UFRN, Natal, RN, Brazil. LA - eng GR - 157144/2021-6/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241125 PL - United States TA - Am J Hum Biol JT - American journal of human biology : the official journal of the Human Biology Council JID - 8915029 SB - IM MH - Humans MH - Male MH - Child MH - Cross-Sectional Studies MH - *Puberty/physiology MH - Adolescent MH - Models, Theoretical MH - Anthropometry/methods OTO - NOTNLM OT - adolescent OT - biological maturation OT - child OT - pediatrics EDAT- 2024/11/25 11:34 MHDA- 2024/12/26 06:20 CRDT- 2024/11/25 05:26 PHST- 2024/11/06 00:00 [revised] PHST- 2024/08/14 00:00 [received] PHST- 2024/11/11 00:00 [accepted] PHST- 2024/12/26 06:20 [medline] PHST- 2024/11/25 11:34 [pubmed] PHST- 2024/11/25 05:26 [entrez] AID - 10.1002/ajhb.24193 [doi] PST - ppublish SO - Am J Hum Biol. 2025 Jan;37(1):e24193. doi: 10.1002/ajhb.24193. Epub 2024 Nov 25. PMID- 39581300 OWN - NLM STAT- MEDLINE DCOM- 20241221 LR - 20241221 IS - 1873-6246 (Electronic) IS - 0301-0511 (Linking) VI - 193 DP - 2024 Nov TI - Can personality traits be predicted from resting-state EEG oscillations? A replication study. PG - 108955 LID - S0301-0511(24)00215-1 [pii] LID - 10.1016/j.biopsycho.2024.108955 [doi] AB - Personality neuroscience seeks to uncover the neurobiological underpinnings of personality. Identifying links between measures of brain activity and personality traits is important in this respect. Using an entirely inductive approach, Jach et al. (2020) attempted to predict personality trait scores from resting-state spectral electroencephalography (EEG) using multivariate pattern analysis (MVPA) and found meaningful results for Agreeableness. The exploratory nature of this work and concerns about replicability in general require a rigorous replication, which was the aim of the current study. We applied the same analytic approach to a large data set (N = 772) to evaluate the robustness of the previous results. Similar to Jach et al. (2020), 8 min of resting-state EEG before and after unrelated tasks with both eyes open and closed were analyzed using support vector regressions (SVR). A 10-fold cross-validation was used to evaluate the prediction accuracy between the spectral power of 59 EEG electrodes within 30 frequency bins ranging from 1 to 30 Hz and Big Five personality trait scores. We were not able to replicate the findings for Agreeableness. We extended the analysis by parameterizing the total EEG signal into its periodic and aperiodic signal components. However, neither component was meaningfully associated with the Big Five personality traits. Our results do not support the initial results and indicate that personality traits may at least not be substantially predictable from resting-state spectral power. Future identification of robust and replicable brain-personality associations will likely require alternative analysis methods and rigorous preregistration of all analysis steps. CI - Copyright (c) 2024 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Fruehlinger, Christoph AU - Fruehlinger C AD - Department of Differential Psychology and Psychological Assessment, Institute of Psychology, University of Hamburg, Von-Melle-Park-5, 20146 Hamburg, Germany. Electronic address: c.fruehlinger@gmail.com. FAU - Paul, Katharina AU - Paul K AD - Department of Differential Psychology and Psychological Assessment, Institute of Psychology, University of Hamburg, Von-Melle-Park-5, 20146 Hamburg, Germany. Electronic address: katharina.paul@uni-hamburg.de. FAU - Wacker, Jan AU - Wacker J AD - Department of Differential Psychology and Psychological Assessment, Institute of Psychology, University of Hamburg, Von-Melle-Park-5, 20146 Hamburg, Germany. Electronic address: jan.wacker@uni-hamburg.de. LA - eng PT - Journal Article DEP - 20241122 PL - Netherlands TA - Biol Psychol JT - Biological psychology JID - 0375566 SB - IM MH - Humans MH - *Personality/physiology MH - *Electroencephalography/methods MH - Male MH - Female MH - Adult MH - Young Adult MH - *Rest/physiology MH - Brain/physiology MH - Adolescent MH - Brain Waves/physiology OTO - NOTNLM OT - Big Five OT - MVPA OT - Personality neuroscience OT - Replication OT - Resting-state EEG COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/11/25 01:26 MHDA- 2024/12/22 00:28 CRDT- 2024/11/24 19:14 PHST- 2024/10/10 00:00 [received] PHST- 2024/11/19 00:00 [revised] PHST- 2024/11/21 00:00 [accepted] PHST- 2024/12/22 00:28 [medline] PHST- 2024/11/25 01:26 [pubmed] PHST- 2024/11/24 19:14 [entrez] AID - S0301-0511(24)00215-1 [pii] AID - 10.1016/j.biopsycho.2024.108955 [doi] PST - ppublish SO - Biol Psychol. 2024 Nov;193:108955. doi: 10.1016/j.biopsycho.2024.108955. Epub 2024 Nov 22. PMID- 39580756 OWN - NLM STAT- MEDLINE DCOM- 20241124 LR - 20241127 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 29 IP - 1 DP - 2024 Nov 24 TI - Psychometric properties of the ORTO-R in an adult population: the Turkish version, reliability, and validity study. PG - 73 LID - 10.1007/s40519-024-01705-0 [doi] LID - 73 AB - PURPOSE: This study aimed to examine the psychometric properties of a Turkish version of the ORTO-R scale by testing its factorial structure, reliability, and validity in a large adult population. METHODS: This cross-sectional study was conducted between November 2022 and February 2023. Through an online questionnaire, 1077 participants were recruited. Confirmatory factor analysis (CFA) was used to examine the construct validity of the questionnaires. The internal consistency of the ORTO-R scale was evaluated with Cronbach's alpha, Omega and test-retest coefficients. For the convergent and divergent validity of the scale, Pearson correlation analysis was performed on the scores of the Eating Attitude Test-26, the Generalized Anxiety Disorder-7 and the Life Satisfaction Scale. RESULTS: The two-factor model fit the data well. Analyses confirmed that the two-factor model of the ORTO-R had acceptable or good fit indices (chi 2/df = 2.126; GFI = 0.997; CFI = 0.992; AGFI = 0.992; TLI = 0.985; RMSEA = 0.032; SRMR = 0.029). According to the reliability coefficients, the orthorexia nervosa and method subscales were found to be reliable. The correlations supported the convergent and divergent validity of the scale. CONCLUSIONS: The results demonstrate that the Turkish version of the ORTO-R is a valid and reliable instrument for assessing orthorexic behaviors in a theoretically meaningful way. LEVEL OF EVIDENCE: Level V, descriptive study. CI - (c) 2024. The Author(s). FAU - Kaya, Seda AU - Kaya S AUID- ORCID: 0000-0001-7918-3142 AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Tokat Gaziosmanpasa University, Tokat, Turkey. dyt.seda06@outlook.com. FAU - Asil, Esma AU - Asil E AUID- ORCID: 0000-0003-0809-4008 AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara University, Ankara, Turkey. FAU - Cakiroglu, Funda Pinar AU - Cakiroglu FP AUID- ORCID: 0000-0003-2324-6874 AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara University, Ankara, Turkey. FAU - Sertdemir, Sumeyye AU - Sertdemir S AUID- ORCID: 0000-0002-0455-6773 AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara University, Ankara, Turkey. FAU - Can, Yaren AU - Can Y AUID- ORCID: 0000-0003-3081-7188 AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara University, Ankara, Turkey. FAU - Muradoglu, Emine AU - Muradoglu E AUID- ORCID: 0000-0002-1899-5507 AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara University, Ankara, Turkey. LA - eng PT - Journal Article PT - Validation Study DEP - 20241124 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - *Psychometrics MH - Adult MH - Female MH - Male MH - Reproducibility of Results MH - Turkey MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - Young Adult MH - Middle Aged MH - *Feeding and Eating Disorders/psychology/diagnosis MH - Factor Analysis, Statistical MH - Adolescent MH - Feeding Behavior/psychology PMC - PMC11586309 OTO - NOTNLM OT - Healthy eating obsession OT - ORTO-R OT - Orthorexia nervosa OT - Reliability OT - Validity COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Ethics Committee of Ankara University (Decision number: 85434274-050.04.04/681117), and the study was conducted by the guidelines of the Declaration of Helsinki. Online informed consent was obtained from all participants who participated in the study. Consent for publication: All participants consented to the publication of their anonymized data. Competing interests: The authors declare no competing interests. EDAT- 2024/11/25 01:10 MHDA- 2024/11/25 01:11 PMCR- 2024/11/24 CRDT- 2024/11/24 11:03 PHST- 2024/07/02 00:00 [received] PHST- 2024/11/10 00:00 [accepted] PHST- 2024/11/25 01:11 [medline] PHST- 2024/11/25 01:10 [pubmed] PHST- 2024/11/24 11:03 [entrez] PHST- 2024/11/24 00:00 [pmc-release] AID - 10.1007/s40519-024-01705-0 [pii] AID - 1705 [pii] AID - 10.1007/s40519-024-01705-0 [doi] PST - epublish SO - Eat Weight Disord. 2024 Nov 24;29(1):73. doi: 10.1007/s40519-024-01705-0. PMID- 39578368 OWN - NLM STAT- MEDLINE DCOM- 20250403 LR - 20250517 IS - 1099-0968 (Electronic) IS - 1072-4133 (Linking) VI - 33 IP - 3 DP - 2025 May TI - Unveiling Severity Indicators for Anorexia and Bulimia Nervosa Treatment Success: DSM-5 Versus ICD-11 Versus Drive for Thinness. PG - 460-471 LID - 10.1002/erv.3156 [doi] AB - OBJECTIVE: This study aimed to compare treatment outcomes associated with three severity indicators-DSM-5 for anorexia nervosa (AN) and bulimia nervosa (BN), ICD-11 for AN, and drive for thinness (DT) for AN and BN-within a treatment-seeking population. METHOD: A total of 628 female participants diagnosed with either AN (n = 266; mean age = 26.71) or BN (n = 362; mean age = 29.49) were recruited from an ED unit. Upon admission, participants were classified based on DSM-5 (AN and BN) and ICD-11 severity categories. They underwent CBT-E comprehensive manualised programs, according to ED subtype, and were categorised into 'full remission', 'partial remission', 'non-remission' or 'drop-out' based on DSM-5 diagnostic criteria at discharge. RESULTS: Significant associations were found only for ICD-11 AN severity groups (p = 0.03, Cramer's V = 0.18), with 'dangerously low BMI' associated with poorer outcomes than 'significantly low BMI'. No other significant relationships were found with DSM-5 or DT severity groups. CONCLUSION: This study reveals the limitation of using a single severity indicator and emphasises the necessity of a comprehensive assessment to capture the complexities of AN and BN. Future research should also evaluate the validity of these severity measures across various factors, including biological correlates and psychopathology. CI - (c) 2024 Eating Disorders Association and John Wiley & Sons Ltd. FAU - Dang, An AU - Dang A AUID- ORCID: 0000-0001-7961-6913 AD - Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Australia. FAU - Granero, Roser AU - Granero R AD - Ciber Fisiopatologia Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, Barcelona, Spain. AD - Department of Psychobiology and Methodology, Universitat Autonoma de Barcelona-UAB, Barcelona, Spain. FAU - Sanchez, Isabel AU - Sanchez I AD - Ciber Fisiopatologia Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, Barcelona, Spain. AD - Department of Clinical Psychology, University Hospital of Bellvitge-IDIBELL and CIBERobn, Barcelona, Spain. FAU - Sole, Laura Galvez AU - Sole LG AD - Clinical Psychology Department, University Hospital of Bellvitge, Barcelona, Spain. FAU - Toro, Jessica Jimenez-Del AU - Toro JJ AD - Clinical Psychology Department, University Hospital of Bellvitge, Barcelona, Spain. FAU - Rosinska, Magda AU - Rosinska M AD - Psychoneurobiology of Eating and Addictive Behaviors Group, Neurosciences Program, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain. FAU - Jimenez-Murcia, Susana AU - Jimenez-Murcia S AD - Department of Clinical Psychology, University Hospital of Bellvitge-IDIBELL and CIBERobn, Barcelona, Spain. AD - Psychoneurobiology of Eating and Addictive Behaviors Group, Neurosciences Program, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain. AD - CIBER Fisiopatologia Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Barcelona, Spain. AD - Department of Clinical Sciences, School of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain. AD - Psychological Services, University of Barcelona, Barcelona, Spain. FAU - Krug, Isabel AU - Krug I AUID- ORCID: 0000-0002-5275-3595 AD - Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Australia. FAU - Fernandez-Aranda, Fernando AU - Fernandez-Aranda F AD - Department of Clinical Psychology, University Hospital of Bellvitge-IDIBELL and CIBERobn, Barcelona, Spain. AD - Psychoneurobiology of Eating and Addictive Behaviors Group, Neurosciences Program, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain. AD - CIBER Fisiopatologia Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Barcelona, Spain. AD - Department of Clinical Sciences, School of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain. LA - eng GR - Instituto de Salud Carlos III/ GR - Department of Health of the Generalitat de Catalunya/ GR - Ministerio de Asuntos Economicos y Transformacion Digital, Gobierno de Espana/ GR - DelegaciA3n del Gobierno para el Plan Nacional sobre Drogas/ GR - Centre for Mental Health Network/ GR - Biomedical Research Centre in Physiopathology of Obesity and Nutrition/ GR - FEDER funds/European Regional Development Fund/ GR - Centres de Recerca de Catalunya/ PT - Comparative Study PT - Journal Article DEP - 20241122 PL - England TA - Eur Eat Disord Rev JT - European eating disorders review : the journal of the Eating Disorders Association JID - 9436977 SB - IM MH - Humans MH - Female MH - *Diagnostic and Statistical Manual of Mental Disorders MH - *Anorexia Nervosa/therapy/diagnosis/psychology MH - Adult MH - *Bulimia Nervosa/therapy/diagnosis/psychology MH - *Severity of Illness Index MH - *International Classification of Diseases MH - Young Adult MH - *Thinness/psychology MH - Treatment Outcome MH - Adolescent MH - *Cognitive Behavioral Therapy OTO - NOTNLM OT - DSM-5 OT - ICD-11 OT - drive for thinness OT - severity ratings OT - treatment outcomes EDAT- 2024/11/23 11:17 MHDA- 2025/04/03 18:25 CRDT- 2024/11/23 00:03 PHST- 2024/08/02 00:00 [revised] PHST- 2024/04/14 00:00 [received] PHST- 2024/10/31 00:00 [accepted] PHST- 2025/04/03 18:25 [medline] PHST- 2024/11/23 11:17 [pubmed] PHST- 2024/11/23 00:03 [entrez] AID - 10.1002/erv.3156 [doi] PST - ppublish SO - Eur Eat Disord Rev. 2025 May;33(3):460-471. doi: 10.1002/erv.3156. Epub 2024 Nov 22. PMID- 39577412 OWN - NLM STAT- MEDLINE DCOM- 20251017 LR - 20260915 IS - 1543-2920 (Electronic) IS - 0899-8493 (Linking) VI - 37 IP - 4 DP - 2025 Nov 1 TI - A Fundamental Movement Skill Test for Preschool Children With and Without Overweight: The SALTO Test Battery. PG - 337-350 LID - 10.1123/pes.2024-0076 [doi] AB - PURPOSE: This study aimed to evaluate a 3-factor model of fundamental movement skills in preschool children, incorporating both process- and product-oriented assessment methods, and to test the model's invariance across subgroups of age, body weight and sex. METHODS: The SALTO test battery was administered to 736 preschool children aged 3-6 years. A single-indicator multitrait-multimethod model was specified with Locomotion, Object Manipulation, and Balance as latent factors and a latent method factor to address the multimethod design. Measurement invariance was tested across subgroups using multigroup confirmatory factor analysis. RESULTS: The 3-factor model yielded good fit indices, confirming the construct validity of the SALzburg Together against Obesity test battery. Strong measurement invariance was found across body mass index groups, whereas partial invariance was observed across age and sex groups. Older children outperformed younger ones in all skill domains, children with overweight had lower skills in Balance and Locomotion, and sex differences were found in Object Manipulation and Balance. CONCLUSION: The SALTO test battery is a structurally valid tool for evaluating and comparing fundamental movement skills in preschool children across age, weight status, and sex. The findings underscore the importance of considering these factors when designing interventions to enhance fundamental movement skills in early childhood. FAU - Birklbauer, Jurgen AU - Birklbauer J AD - Department of Sport and Exercise Science, University of Salzburg, Salzburg,Austria. FAU - Gniewosz, Burkhard AU - Gniewosz B AD - Department of Quantitative Research Methods in Educational Science, University of Salzburg, Salzburg,Austria. FAU - Freudenthaler, Thomas AU - Freudenthaler T AD - Department of Sport and Exercise Science, University of Salzburg, Salzburg,Austria. FAU - Birklbauer, Anita AU - Birklbauer A AD - Department of Sport and Exercise Science, University of Salzburg, Salzburg,Austria. AD - Sportrix, die Spowi-Praxis, Elixhausen,Austria. FAU - Potzelsberger, Birgit AU - Potzelsberger B AD - Department of Sport and Exercise Science, University of Salzburg, Salzburg,Austria. FAU - Wiesinger, Hans-Peter AU - Wiesinger HP AD - Department of Sport and Exercise Science, University of Salzburg, Salzburg,Austria. AD - Institute of Nursing Science and Practice, Center for Public Health and Healthcare Research, Paracelsus Medical University, Salzburg,Austria. AD - Institute of General Practice, Family Medicine and Preventive Medicine, Paracelsus Medical University, Salzburg,Austria. FAU - Weghuber, Daniel AU - Weghuber D AD - Department of Pediatrics, Paracelsus Medical University and Gemeinnuetzige Salzburger Landeskliniken Betriebsgesellschaft, Salzburg,Austria. FAU - Ring-Dimitriou, Susanne AU - Ring-Dimitriou S AD - Department of Sport and Exercise Science, University of Salzburg, Salzburg,Austria. LA - eng PT - Journal Article DEP - 20241122 PL - United States TA - Pediatr Exerc Sci JT - Pediatric exercise science JID - 8909729 SB - IM MH - Humans MH - Child, Preschool MH - Male MH - Female MH - *Motor Skills/physiology MH - Child MH - *Overweight/physiopathology MH - Body Mass Index MH - Postural Balance MH - Sex Factors MH - Age Factors MH - Locomotion MH - Reproducibility of Results MH - Movement MH - *Exercise Test/methods MH - *Pediatric Obesity/physiopathology OTO - NOTNLM OT - childhood obesity OT - construct validity OT - measurement invariance OT - motor competence OT - multitrait-multimethod EDAT- 2024/11/23 11:13 MHDA- 2025/10/17 18:27 CRDT- 2024/11/22 18:34 PHST- 2024/05/10 00:00 [received] PHST- 2024/08/14 00:00 [revised] PHST- 2024/09/05 00:00 [accepted] PHST- 2025/10/17 18:27 [medline] PHST- 2024/11/23 11:13 [pubmed] PHST- 2024/11/22 18:34 [entrez] AID - 10.1123/pes.2024-0076 [doi] PST - epublish SO - Pediatr Exerc Sci. 2024 Nov 22;37(4):337-350. doi: 10.1123/pes.2024-0076. Print 2025 Nov 1. PMID- 39576791 OWN - NLM STAT- MEDLINE DCOM- 20241122 LR - 20260902 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 11 DP - 2024 TI - Evidence for a specific distortion in perceptual body image in eating disorders: A replication and extension. PG - e0313619 LID - 10.1371/journal.pone.0313619 [doi] LID - e0313619 AB - A core feature of eating disorders, such as anorexia nervosa, is an overestimation of body size. A key question is whether this overestimation arises solely from body image concerns typical in eating disorders, or if there is an additional perceptual disturbance. To address this question, we applied a two-component model of body size estimation that has been thoroughly replicated in the body image literature concerning healthy individuals. This model shows statistically independent, additive effects on body size estimates of: a) body image concerns, and b) a perceptual component known as contraction bias. Here body image concerns were defined by a principal components analysis (PCA) of psychometric tasks including the: Eating Disorder Examination Questionnaire, Beck Depression Inventory, Body Shape Questionnaire, Rosenberg Self-Esteem Scale, and Sociocultural Attitudes Towards Appearance Questionnaire-4. The PCA identified three components referred to as PSYCH, FAMPEER, and ATHIN. We investigated the influence of age, personal body mass index (BMI), and these three components on body size estimation in 33 women with a current or past history of eating disorders and 100 healthy controls. Low-BMI control participants overestimated their size, while high-BMI controls underestimated their size, exhibiting the expected normal perceptual contraction bias. However, the women with a history of eating disorders showed no evidence of contraction bias, suggesting a different processing of perceptual aspects of body size estimation compared to controls. We discuss two putative mechanisms that can explain these differences in accuracy of personal body size estimation. CI - Copyright: (c) 2024 Brokjob et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Brokjob, Lise Gulli AU - Brokjob LG AD - Department of Psychology, The Artic University of Norway, Tromso, Norway. FAU - Cornelissen, Piers L AU - Cornelissen PL AUID- ORCID: 0000-0002-2695-9581 AD - Department of Psychology, Northumbria University, Newcastle upon Tyne, United Kingdom. FAU - Gumancik, Jiri AU - Gumancik J AUID- ORCID: 0000-0002-9978-5930 AD - Department of Psychology, Northumbria University, Newcastle upon Tyne, United Kingdom. FAU - McCarty, Kristofor AU - McCarty K AD - Department of Psychology, Northumbria University, Newcastle upon Tyne, United Kingdom. FAU - Tovee, Martin J AU - Tovee MJ AD - Department of Psychology, Northumbria University, Newcastle upon Tyne, United Kingdom. FAU - Cornelissen, Katri K AU - Cornelissen KK AD - Department of Psychology, Northumbria University, Newcastle upon Tyne, United Kingdom. LA - eng PT - Journal Article DEP - 20241122 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - *Body Image/psychology MH - *Feeding and Eating Disorders/psychology/physiopathology MH - Adult MH - Young Adult MH - Body Mass Index MH - Surveys and Questionnaires MH - Body Size MH - Self Concept MH - Adolescent MH - Principal Component Analysis MH - Psychometrics/methods MH - Case-Control Studies PMC - PMC11584124 COIS- The authors have declared that no competing interests exist. EDAT- 2024/11/22 18:16 MHDA- 2024/11/22 18:17 PMCR- 2024/11/22 CRDT- 2024/11/22 13:34 PHST- 2024/07/18 00:00 [received] PHST- 2024/10/28 00:00 [accepted] PHST- 2024/11/22 18:17 [medline] PHST- 2024/11/22 18:16 [pubmed] PHST- 2024/11/22 13:34 [entrez] PHST- 2024/11/22 00:00 [pmc-release] AID - PONE-D-24-29868 [pii] AID - 10.1371/journal.pone.0313619 [doi] PST - epublish SO - PLoS One. 2024 Nov 22;19(11):e0313619. doi: 10.1371/journal.pone.0313619. eCollection 2024. PMID- 39575555 OWN - NLM STAT- MEDLINE DCOM- 20250426 LR - 20260824 IS - 1098-108X (Electronic) IS - 0276-3478 (Linking) VI - 58 IP - 2 DP - 2025 Feb TI - Eating-Specific Interpersonal Difficulties: Changes and Impacts on Outcomes During Ten-Session Cognitive Behavioral Therapy for Eating Disorders (CBT-T). PG - 362-371 LID - 10.1002/eat.24336 [doi] AB - OBJECTIVE: The relationship between self-reported interpersonal difficulties and eating disorder symptoms is well-established. The Interpersonal Relationships in Eating Disorders (IR-ED) is a new measure of eating-specific interpersonal difficulties (food-related isolation, avoidance of body evaluation, foot-related interpersonal tension). This study aims to (1) explore changes in IR-ED scores, eating disorder symptoms, and psychosocial impairment during ten-session cognitive behavioral therapy for eating disorders (CBT-T), (2) assess whether pre-treatment IR-ED scores moderate the trajectory of change in eating disorder symptoms and psychosocial impairment during CBT-T and (3) investigate the relationship between changes in the IR-ED and changes in eating disorder symptoms and psychosocial impairment. METHOD: Individuals with eating disorders (N = 126, M (age) = 26.08) received CBT-T and completed questionnaires at pre-, mid-, and post-treatment. RESULTS: Eating-specific interpersonal difficulties, eating disorder symptoms, and psychosocial impairment reduced during CBT-T. Severity of pre-treatment eating-specific interpersonal difficulties was unrelated to change in eating disorder symptoms or psychosocial impairment, irrespective of diagnosis or body mass index. Changes in interpersonal difficulties were associated with concurrent changes in eating disorder symptoms and psychosocial impairment. Early change in interpersonal difficulties did not predict later change in eating disorder symptoms or psychosocial impairment, and early changes in symptoms or psychosocial impairment did not predict later changes in interpersonal difficulties. CONCLUSIONS: Eating-specific interpersonal difficulties improve during CBT-T, and individuals benefit from treatment regardless of their pre-treatment interpersonal difficulties. Theoretical and clinical implications are discussed. CI - (c) 2024 Wiley Periodicals LLC. FAU - Arai, Mia AU - Arai M AUID- ORCID: 0009-0005-8014-848X AD - Discipline of Psychology, School of Population Health, Curtin University, Perth, Western Australia, Australia. FAU - Tonta, Kate E AU - Tonta KE AUID- ORCID: 0000-0002-2836-9833 AD - Discipline of Psychology, School of Population Health, Curtin University, Perth, Western Australia, Australia. AD - Centre for Clinical Interventions, Perth, Western Australia, Australia. AD - Curtin enAble Institute, Curtin University, Perth, Western Australia, Australia. FAU - Erceg-Hurn, David M AU - Erceg-Hurn DM AUID- ORCID: 0000-0002-1885-6160 AD - Centre for Clinical Interventions, Perth, Western Australia, Australia. FAU - Raykos, Bronwyn C AU - Raykos BC AUID- ORCID: 0000-0003-3640-4229 AD - Centre for Clinical Interventions, Perth, Western Australia, Australia. FAU - Waller, Glenn AU - Waller G AUID- ORCID: 0000-0001-7794-9546 AD - Department of Psychology, University of Sheffield, Sheffield, UK. FAU - McEvoy, Peter M AU - McEvoy PM AUID- ORCID: 0000-0003-2924-6760 AD - Discipline of Psychology, School of Population Health, Curtin University, Perth, Western Australia, Australia. AD - Centre for Clinical Interventions, Perth, Western Australia, Australia. AD - Curtin enAble Institute, Curtin University, Perth, Western Australia, Australia. LA - eng PT - Journal Article DEP - 20241122 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM MH - Humans MH - *Cognitive Behavioral Therapy/methods MH - *Feeding and Eating Disorders/therapy/psychology MH - Female MH - Adult MH - *Interpersonal Relations MH - Male MH - Young Adult MH - Treatment Outcome MH - Adolescent MH - Surveys and Questionnaires OTO - NOTNLM OT - assessment OT - clinical impairment OT - cognitive behavior therapy OT - eating disorders OT - interpersonal difficulties OT - interpersonal problems OT - psychometrics EDAT- 2024/11/22 06:23 MHDA- 2025/02/26 06:28 CRDT- 2024/11/22 04:53 PHST- 2024/11/05 00:00 [revised] PHST- 2024/07/15 00:00 [received] PHST- 2024/11/06 00:00 [accepted] PHST- 2025/02/26 06:28 [medline] PHST- 2024/11/22 06:23 [pubmed] PHST- 2024/11/22 04:53 [entrez] AID - 10.1002/eat.24336 [doi] PST - ppublish SO - Int J Eat Disord. 2025 Feb;58(2):362-371. doi: 10.1002/eat.24336. Epub 2024 Nov 22. PMID- 39575191 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241123 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 15 DP - 2024 TI - Utilizing machine learning techniques to identify severe sleep disturbances in Chinese adolescents: an analysis of lifestyle, physical activity, and psychological factors. PG - 1447281 LID - 10.3389/fpsyt.2024.1447281 [doi] LID - 1447281 AB - BACKGROUND: Adolescents often experience difficulties with sleep quality. The existing literature on predicting severe sleep disturbance is limited, primarily due to the absence of reliable tools. METHODS: This study analyzed 1966 university students. All participants were classified into a training set and a validation set at the ratio of 8:2 at random. Participants in the training set were utilized to establish models, and the logistic regression (LR) and five machine learning algorithms, including the eXtreme Gradient Boosting Machine (XGBM), Naive Bayesian (NB), Support Vector Machine (SVM), Decision Tree (DT), CatBoosting Machine (CatBM), were utilized to develop models. Whereas, those in the validation set were used to validate the developed models. RESULTS: The incidence of severe sleep disturbance was 5.28% (104/1969). Among all developed models, the XGBM model performed best in AUC (0.872 [95%CI: 0.848-0.896]), followed by the CatBM model (0.853 [95% CI: 0.821-0.878]) and DT model (0.843 [95% CI: 0.801-0.870]), whereas the AUC of the logistic regression model was only 0.822 (95% CI: 0.777-0.856). Additionally, the XGBM model had the best accuracy (0.792), precision (0.780), F1 score (0.796), Brier score (0.143), and log loss (0.444). CONCLUSIONS: The XGBM model may be a useful tool to estimate the risk of experiencing severe sleep disturbance among adolescents. CI - Copyright (c) 2024 Zhang, Zhao, Yang, Yang, Wu, Zheng and Lei. FAU - Zhang, Lirong AU - Zhang L AD - Department of Physical Education, Xiamen University of Technology, Xiamen, Fujian, China. FAU - Zhao, Shaocong AU - Zhao S AD - Department of Physical Education, Xiamen University of Technology, Xiamen, Fujian, China. FAU - Yang, Wei AU - Yang W AD - Department of Physical Education, Xiamen University of Technology, Xiamen, Fujian, China. FAU - Yang, Zhongbing AU - Yang Z AD - School of Physical Education, Guizhou Normal University, Guiyang, Guizhou, China. FAU - Wu, Zhi'an AU - Wu Z AD - Department of Physical Education, Guangzhou Institute of Physical Education, Guangzhou, China. FAU - Zheng, Hua AU - Zheng H AD - College of Physical Education and Health Sciences, Chongqing Normal University, Chongqing, China. FAU - Lei, Mingxing AU - Lei M AD - Department of Orthopaedics, Hainan Hospital of Chinse PLA General Hospital, Sanya, China. AD - Nursing Department, The First Medical Center of Chinese PLA General Hospital, Beijing, China. AD - Chinese PLA Medical School, Beijing, China. LA - eng PT - Journal Article DEP - 20241107 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC11578992 OTO - NOTNLM OT - Pittsburgh sleep quality index OT - adolescents OT - epidemiology OT - machine learning OT - prediction model OT - sleep disturbance COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/11/22 11:25 MHDA- 2024/11/22 11:26 PMCR- 2024/11/07 CRDT- 2024/11/22 04:29 PHST- 2024/06/27 00:00 [received] PHST- 2024/10/21 00:00 [accepted] PHST- 2024/11/22 11:26 [medline] PHST- 2024/11/22 11:25 [pubmed] PHST- 2024/11/22 04:29 [entrez] PHST- 2024/11/07 00:00 [pmc-release] AID - 10.3389/fpsyt.2024.1447281 [doi] PST - epublish SO - Front Psychiatry. 2024 Nov 7;15:1447281. doi: 10.3389/fpsyt.2024.1447281. eCollection 2024. PMID- 39575104 OWN - NLM STAT- MEDLINE DCOM- 20241122 LR - 20261029 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 12 DP - 2024 TI - Socio-demographic determinants of dietary choices and their impact on health in Spanish adults. PG - 1417925 LID - 10.3389/fpubh.2024.1417925 [doi] LID - 1417925 AB - BACKGROUND: Although Spain has traditionally followed the Mediterranean diet, in recent years, changes have become noticeable in the food preferences of the population. These changes include adopting new diets and dietary trends, such as plant-based diets, intermittent fasting and raw food diets. These choices are influenced by cultural, social and socio-demographic factors, and their impact on health should be studied in detail. AIM: The objectives of this research are: (1) to study the prevalence of different dietary patterns among the Spanish population, (2) to explore the dependence of dietary choice on socio-demographic factors, (3) to investigate the relationship between the social habits and lifestyle choices of the population and how it affects health. METHODS: A descriptive cross-sectional study was carried out on the Spanish population. Using a questionnaire constructed and validated by the research team, socio-demographic data were collected and different nutritional, social and lifestyle habits of the targeted population were explored. RESULTS: A valid sample of 22,181 people was collected among which 17,573 (79.2%) people claimed to follow a Mediterranean dietary pattern, 1,425 (6.4%) people followed a plant-based diet, 365 (1.6%) people are vegans, 1,018 people (4.6%) practiced intermittent fasting, 252 (1.1%) people followed a raw food diet and 1,548 people (7%) claimed to follow other types of diets. The data show that younger people (18-25 years old) tend to adopt more often a plant-based diet than older people and that women tend to follow this type of diet more often than men. On the other hand, men seem to practice intermittent fasting more frequently. A higher tendency to practice a raw food diet was found among people living in villages than those living in cities. Moreover, some trends were found in different regions of Spain, with greater adherence to a plant-based diet in Catalonia, while intermittent fasting is more common in the Region of Murcia. Finally, the results indicate that individuals who pay attention to their diet and experiment with various dietary patterns are generally more health-conscious. This is reflected in their adoption of healthier behaviors, such as exercising more and reducing their intake of alcohol and sugary drinks. CI - Copyright (c) 2024 Sandri, Cantin Larumbe, Capoferri, Cerda Olmedo, Werner and Vega-Bello. FAU - Sandri, Elena AU - Sandri E AD - Faculty of Medicine and Health Sciences, Catholic University of Valencia San Vicente Martir, Valencia, Spain. AD - Doctoral School, Catholic University of Valencia San Vicente Martir, Valencia, Spain. FAU - Cantin Larumbe, Eva AU - Cantin Larumbe E AD - Degree in Data Science, Polytechnical University of Valencia, Valencia, Spain. FAU - Capoferri, Michela AU - Capoferri M AD - Faculty of Medicine and Health Sciences, Catholic University of Valencia San Vicente Martir, Valencia, Spain. FAU - Cerda Olmedo, German AU - Cerda Olmedo G AD - Faculty of Medicine and Health Sciences, Catholic University of Valencia San Vicente Martir, Valencia, Spain. FAU - Werner, Lisa Ursula AU - Werner LU AD - Faculty of Teaching and Science of Education, Catholic University of Valencia San Vicente Martir, Valencia, Spain. FAU - Vega-Bello, M Jesus AU - Vega-Bello MJ AD - Faculty of Medicine and Health Sciences, Catholic University of Valencia San Vicente Martir, Valencia, Spain. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241107 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Spain MH - Male MH - Female MH - Adult MH - Cross-Sectional Studies MH - Middle Aged MH - Surveys and Questionnaires MH - *Diet, Mediterranean/statistics & numerical data MH - Feeding Behavior MH - Food Preferences MH - Adolescent MH - Young Adult MH - Life Style MH - Choice Behavior MH - Aged MH - Socioeconomic Factors MH - Diet/statistics & numerical data PMC - PMC11578831 OTO - NOTNLM OT - Spain OT - diet food and nutrition OT - healthy lifestyle OT - socioeconomic factors OT - survey COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/11/22 06:23 MHDA- 2024/11/22 06:24 PMCR- 2024/11/07 CRDT- 2024/11/22 04:27 PHST- 2024/04/15 00:00 [received] PHST- 2024/10/24 00:00 [accepted] PHST- 2024/11/22 06:24 [medline] PHST- 2024/11/22 06:23 [pubmed] PHST- 2024/11/22 04:27 [entrez] PHST- 2024/11/07 00:00 [pmc-release] AID - 10.3389/fpubh.2024.1417925 [doi] PST - epublish SO - Front Public Health. 2024 Nov 7;12:1417925. doi: 10.3389/fpubh.2024.1417925. eCollection 2024. PMID- 39574529 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241123 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 11 DP - 2024 TI - Protecting optimal childhood growth: systematic nutritional screening, assessment, and intervention for children at risk of malnutrition in the Kingdom of Saudi Arabia. PG - 1483234 LID - 10.3389/fnut.2024.1483234 [doi] LID - 1483234 AB - BACKGROUND: In 2024, the Kingdom of Saudi Arabia Advisory Board on Pediatric Nutrition (KSA-ABPN) reviewed childhood undernutrition in the Middle East. We sought to foster efficient nutritional care for infants and children at nutritional risk. Severe malnutrition due to starvation is rare in Saudi Arabia, so we focused on early recognition and treatment of children with mild growth impairment that forewarns risk for further nutritional decline. This paper summarizes our findings and introduces a recommended guide for nutritional screening, assessment, and follow-up interventions. OBJECTIVE: The KSA-ABPN aimed to build an algorithm with pathways and tools to facilitate up-to-date nutrition-care practices for infants and children. The algorithm is intended to encourage consistent professional training-for and use-of validated tools, adoption of standardized thresholds for intervention, and delivery of nutritional support. Consistent care will increase opportunities for comparative analyses of various treatment strategies and their health and cost outcomes. RECOMMENDATIONS: We developed a 4-stage algorithm for identifying and caring for children at nutritional risk: (i) screening for clinical risk factors and age-related growth measures, (ii) observation of malnutrition-related physical signs, diet history, and/or laboratory detection of evidence indicating specific nutrient deficiencies, (iii) assessment of the severity of nutritional deficit, and (iv) development of a patient-specific Nutrition Care Plan that includes diet counseling, supplementation, routine monitoring, and follow-up. CONCLUSIONS: By helping professionals identify nutritional risk and specific nutritional deficits in infants and children early in the clinical course, we seek to expand quality nutritional care and ensure that children grow and develop fully. CI - Copyright (c) 2024 Murray, Shaaban, Al Amrani, Aldekhail, Alhaffaf, Alharbi, Almehaidib, Al-Suyufi, Al-Turaiki, Amin, Hasosah, Alkhormi, Mirza, Sleiman and Sukkar. FAU - Murray, Robert D AU - Murray RD AD - Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, United States. FAU - Shaaban, Sanaa Y AU - Shaaban SY AD - Faculty of Medicine, Ain Shams University, Cairo, Egypt. FAU - Al Amrani, Mohammed AU - Al Amrani M AD - Division of Gastroenterology, Department of Pediatrics, Sulaiman Al Habib Medical Services Group, Riyadh, Saudi Arabia. FAU - Aldekhail, Wajeeh AU - Aldekhail W AD - Department of Pediatrics-Gastroenterology Section, King Faisal Hospital and Research Center, Riyadh, Saudi Arabia. FAU - Alhaffaf, Faisal A AU - Alhaffaf FA AD - Department of Pediatrics-Gastroenterology Division, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. FAU - Alharbi, Abdulaziz O AU - Alharbi AO AD - Pediatric Gastroenterology Department, King Saud Hospital Ministry of Health, Riyadh, Saudi Arabia. FAU - Almehaidib, Ali AU - Almehaidib A AD - Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. FAU - Al-Suyufi, Yasir AU - Al-Suyufi Y AD - Department of Pediatrics, King Saud Hospital, Unaizah, Qassim, Saudi Arabia. FAU - Al-Turaiki, Muath AU - Al-Turaiki M AD - Pediatric Department, King Salman Hospital, Ministry of Health, Riyadh, Saudi Arabia. FAU - Amin, Ahmed AU - Amin A AD - Abbott Laboratories, Dubai, United Arab Emirates. FAU - Hasosah, Mohammed Y AU - Hasosah MY AD - Pediatric Gastroenterology Department, King Abdullah International Medical Research Center, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia. FAU - Alkhormi, Musa AU - Alkhormi M AD - Pediatric Gastroenterology Division, King Saud Medical City, Dallah Namar Hospital, Riyadh, Saudi Arabia. FAU - Mirza, Ziyad T AU - Mirza ZT AD - Division of Pediatric Gastroenterology, Department of Pediatrics, King Fahd Armed Forces Hospital, Jeddah, Saudi Arabia. FAU - Sleiman, Rola AU - Sleiman R AD - Al Habib Medical Group, Al Rayyan Hospital, Riyadh, Saudi Arabia. FAU - Sukkar, Ghassan AU - Sukkar G AD - Department of Pediatrics, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia. LA - eng PT - Journal Article DEP - 20241107 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC11580261 OTO - NOTNLM OT - diet quality OT - mid-upper arm circumference (MUAC) OT - pediatric OT - risk assessment OT - screening OT - undernutrition OT - z-score COIS- RM and SYS report having received honoraria from Abbott for their speaking presentations at the KSA-ABPN meeting and for expert consultations on the algorithm before and after the meeting. AAm reports that he is an employee of Abbott. All other authors received honoraria from Abbott for their participation in the KSA-ABPN meeting and for their participation in development of the Pediatric Nutrition Algorithm. AAl reports receiving honoraria from Nestle, Nutricia, Novalac, Kabrita, Almaraai, and Ordesa. MA-T declares honoraria from Nestle and Danone, RS reports financial support from Nestle, Danone, Pfizer, and GSK and SYS has also received honoraria from Sandoz, Hero, and Liptis Nutrition. Nutritional care recommendations in this paper were evidence-based and were agreed upon by consensus of meeting attendees/authors. The content of the final paper was reviewed and approved by all authors. EDAT- 2024/11/22 11:25 MHDA- 2024/11/22 11:26 PMCR- 2024/01/01 CRDT- 2024/11/22 04:16 PHST- 2024/08/19 00:00 [received] PHST- 2024/10/14 00:00 [accepted] PHST- 2024/11/22 11:26 [medline] PHST- 2024/11/22 11:25 [pubmed] PHST- 2024/11/22 04:16 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - 10.3389/fnut.2024.1483234 [doi] PST - epublish SO - Front Nutr. 2024 Nov 7;11:1483234. doi: 10.3389/fnut.2024.1483234. eCollection 2024. PMID- 39574052 OWN - NLM STAT- MEDLINE DCOM- 20241122 LR - 20241124 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 Nov 21 TI - Clustering of diet and physical activity behaviours in adolescents across home and school area-level deprivation in Cameroon, South Africa, and Jamaica. PG - 3234 LID - 10.1186/s12889-024-20683-7 [doi] LID - 3234 AB - BACKGROUND: Adolescence is a crucial period for establishing healthy behaviours that can reduce the risk of noncommunicable diseases. However, limited data exist on the clustering of health-related behaviours, in adolescents from low- and middle-income countries (LMICs). This study examined how diet and physical activity behaviours cluster and how they are influenced by home and school area-level deprivation. METHODS: The study surveyed 527 adolescents in Yaounde (Cameroon), Kingston (Jamaica), and Cape Town (South Africa) and grouped them into three categories according to the socioeconomic status (SES) of their homes and school areas (low-low, low-high, and high-high). A k-median algorithm defined three clusters and measured dietary attributes including Dietary Habit Score (DHS), Healthy Food Score (HFS), Nutritional Knowledge Questionnaire (NKQ), moderate-to-vigorous physical activity (MVPA), and sedentary time using validated questionnaires. The clusters were ranked based on their physical activity levels and compared them within each city using statistical tests. RESULTS: The scores on the NKQ and HFS indicated a poor level of both nutritional knowledge and healthy food consumption across sites. Cluster analysis revealed a consistent pattern of high screen time clustering with lower (less healthy) dietary scores across sites. This pattern was consistent regardless of SES in Kingston, and SES and school socioeconomic areas in Cape Town and Yaounde. CONCLUSION: An inverse clustering of sedentary behaviour duration and eating habits remained consistent across different strata for at least two sites, suggesting that interventions to reduce sedentary time could have a ripple effect on multiple NCD risk factors in adolescence. CI - (c) 2024. The Author(s). FAU - Wasnyo, Yves AU - Wasnyo Y AD - Health of Population in Transition, University of Yaounde 1, Yaounde, Cameroon. yves.wasnyo@fmsb-uy1.cm. FAU - Tatah, Lambed AU - Tatah L AD - Health of Population in Transition, University of Yaounde 1, Yaounde, Cameroon. AD - Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom. FAU - Wayas, Feyisayo A AU - Wayas FA AD - Department of Human Biology, Division of Physiological Sciences, Research Centre for Health through Physical Activity, Lifestyle and Sport (HPALS), Faculty of Health Sciences, University of Cape Town, Cape Town, 7700, South Africa. FAU - Mapa-Tassou, Clarisse AU - Mapa-Tassou C AD - Health of Population in Transition, University of Yaounde 1, Yaounde, Cameroon. AD - Faculty of Medicine and Pharmacological Sciences, University of Dschang, Dschang, Cameroon. FAU - Luan, Jian'an AU - Luan J AD - Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom. FAU - Micklesfield, Lisa K AU - Micklesfield LK AD - SAMRC-Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. FAU - Smith, Joanne A AU - Smith JA AD - Epidemiology Research Unit, Caribbean Institute for Health Research, The University of the West Indies, Mona, Kingston, Jamaica. FAU - Farr, Colin AU - Farr C AD - Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom. FAU - Foley, Louise AU - Foley L AD - Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom. FAU - Lambert, Estelle V AU - Lambert EV AD - Department of Human Biology, Division of Physiological Sciences, Research Centre for Health through Physical Activity, Lifestyle and Sport (HPALS), Faculty of Health Sciences, University of Cape Town, Cape Town, 7700, South Africa. FAU - Mbanya, Jean Claude AU - Mbanya JC AD - Health of Population in Transition, University of Yaounde 1, Yaounde, Cameroon. FAU - Assah, Felix AU - Assah F AD - Health of Population in Transition, University of Yaounde 1, Yaounde, Cameroon. FAU - Oni, Tolu AU - Oni T AD - Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom. LA - eng GR - 16/137/34/National Institute for Health and Care Research/ GR - 16/137/34/National Institute for Health and Care Research/ GR - 16/137/34/National Institute for Health and Care Research/ GR - 16/137/34/National Institute for Health and Care Research/ GR - 16/137/34/National Institute for Health and Care Research/ GR - 16/137/34/National Institute for Health and Care Research/ GR - 16/137/34/National Institute for Health and Care Research/ GR - 16/137/34/National Institute for Health and Care Research/ GR - 16/137/34/National Institute for Health and Care Research/ GR - 16/137/34/National Institute for Health and Care Research/ GR - 16/137/34/National Institute for Health and Care Research/ GR - 16/137/34/National Institute for Health and Care Research/ GR - 16/137/34/National Institute for Health and Care Research/ PT - Journal Article DEP - 20241121 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Adolescent MH - South Africa MH - Cameroon MH - *Exercise MH - Female MH - Male MH - Cluster Analysis MH - *Diet/statistics & numerical data MH - Schools MH - Health Behavior MH - Adolescent Behavior/psychology MH - Surveys and Questionnaires MH - Child MH - Sedentary Behavior PMC - PMC11580344 OTO - NOTNLM OT - Activity OT - Adolescents OT - Clustering OT - Deprivation OT - Diet COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Centre Regional Ethics Committee of the Human Health Research (CE No. 1836 CRERSHC/2020) in Yaounde) and relevant education departments such as the school district administration and principals of selected schools. This study was conducted in accordance with the Declaration of Helsinki and the Association for Adolescent Health Research Guidelines [73] Written. Informed assent was obtained from all adolescents (aged < 18 years), and written informed consent was obtained from their parents or caregivers. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2024/11/22 06:22 MHDA- 2024/11/22 06:23 PMCR- 2024/11/21 CRDT- 2024/11/22 03:06 PHST- 2024/08/06 00:00 [received] PHST- 2024/11/08 00:00 [accepted] PHST- 2024/11/22 06:23 [medline] PHST- 2024/11/22 06:22 [pubmed] PHST- 2024/11/22 03:06 [entrez] PHST- 2024/11/21 00:00 [pmc-release] AID - 10.1186/s12889-024-20683-7 [pii] AID - 20683 [pii] AID - 10.1186/s12889-024-20683-7 [doi] PST - epublish SO - BMC Public Health. 2024 Nov 21;24(1):3234. doi: 10.1186/s12889-024-20683-7. PMID- 39570064 OWN - NLM STAT- Publisher LR - 20241121 IS - 1764-1489 (Print) IS - 1764-1489 (Linking) DP - 2024 Nov 21 TI - Sleep breathing disorders in adolescents with asthma. LID - 10.23822/EurAnnACI.1764-1489.377 [doi] AB - Background. Childhood asthma, a chronic inflammatory disease, is linked to sleep-breathing disorders (SBD). The vulnerability of asthmatic children to SBDs is well-established, yet limited research focuses on adolescents. This study addresses the research gap, exploring the frequency and risk factors of SBD in adolescents with asthma. Methods. A cross-sectional study was conducted among 98 adolescents (12-17 years) with asthma at a Lisbon healthcare facility. Comprehensive assessments, including sociodemographic data, medical history, lung function variables, and validated questionnaires for SBD risk (Pediatric Sleep Questionnaire), rhinitis control, and asthma control (Control of Allergic Rhinitis and Asthma Test and Asthma Control Test), were employed. Results. The study revealed a substantial frequency of SBD symptoms, with 25.5% of adolescents classified as high-risk based on the Pediatric Sleep Questionnaire. Significant associations were identified between high SBD risk and elevated body mass index (BMI), uncontrolled rhinitis, and uncontrolled asthma. Logistic regression analysis confirmed elevated BMI as a robust predictor of SBD risk, indicating a 5.9-fold increase compared to normal-weight counterparts. Conclusions. This study contributes valuable insights into the interplay between asthma and SBD in adolescents. The high prevalence of SBD symptoms, particularly among those with excess weight and uncontrolled respiratory symptoms, underscores the need for targeted preventive strategies. The identified risk factors, notably elevated BMI, provide clinicians with actionable information for intervention, emphasizing the importance of addressing modifiable factors associated with asthma and SBD in this specific population. FAU - Simao Coelho, P AU - Simao Coelho P AD - Allergy and Clinical Immunology Department, Hospital de Dona Estefania, Unidade Local de Saude (ULS) Sao Jose, Lisbon, Portugal. AD - Lisbon Academic Center, Lisbon, Portugal. FAU - Martins-Dos-Santos, G AU - Martins-Dos-Santos G AD - Allergy and Clinical Immunology Department, Hospital de Dona Estefania, Unidade Local de Saude (ULS) Sao Jose, Lisbon, Portugal. AD - Lisbon Academic Center, Lisbon, Portugal. FAU - Mikovic, M AU - Mikovic M AD - Allergy and Clinical Immunology Department, Hospital de Dona Estefania, Unidade Local de Saude (ULS) Sao Jose, Lisbon, Portugal. AD - Lisbon Academic Center, Lisbon, Portugal. FAU - Carvalho, F AU - Carvalho F AD - Allergy and Clinical Immunology Department, Hospital de Dona Estefania, Unidade Local de Saude (ULS) Sao Jose, Lisbon, Portugal. AD - Lisbon Academic Center, Lisbon, Portugal. FAU - Cardoso, M AU - Cardoso M AD - Allergy and Clinical Immunology Department, Hospital de Dona Estefania, Unidade Local de Saude (ULS) Sao Jose, Lisbon, Portugal. AD - Lisbon Academic Center, Lisbon, Portugal. FAU - Serranho, S AU - Serranho S AD - Allergy and Clinical Immunology Department, Hospital de Dona Estefania, Unidade Local de Saude (ULS) Sao Jose, Lisbon, Portugal. AD - Lisbon Academic Center, Lisbon, Portugal. FAU - Santos, S AU - Santos S AD - Allergy and Clinical Immunology Department, Hospital de Dona Estefania, Unidade Local de Saude (ULS) Sao Jose, Lisbon, Portugal. AD - Lisbon Academic Center, Lisbon, Portugal. FAU - Brito, A AU - Brito A AD - Allergy and Clinical Immunology Department, Hospital de Dona Estefania, Unidade Local de Saude (ULS) Sao Jose, Lisbon, Portugal. AD - Lisbon Academic Center, Lisbon, Portugal. FAU - Carreiro-Martins, P AU - Carreiro-Martins P AD - Allergy and Clinical Immunology Department, Hospital de Dona Estefania, Unidade Local de Saude (ULS) Sao Jose, Lisbon, Portugal. AD - Lisbon Academic Center, Lisbon, Portugal. AD - Comprehensive Health Research Center (CHRC), NOVA Medical School, Universidade Nova de Lisboa, Lisbon, Portugal. FAU - Leiria-Pinto, P AU - Leiria-Pinto P AD - Allergy and Clinical Immunology Department, Hospital de Dona Estefania, Unidade Local de Saude (ULS) Sao Jose, Lisbon, Portugal. AD - Lisbon Academic Center, Lisbon, Portugal. AD - Comprehensive Health Research Center (CHRC), NOVA Medical School, Universidade Nova de Lisboa, Lisbon, Portugal. LA - eng PT - Journal Article DEP - 20241121 PL - Italy TA - Eur Ann Allergy Clin Immunol JT - European annals of allergy and clinical immunology JID - 101466614 SB - IM OTO - NOTNLM OT - Asthma OT - adolescents OT - body mass index OT - sleep-breathing disorders EDAT- 2024/11/21 12:24 MHDA- 2024/11/21 12:24 CRDT- 2024/11/21 09:33 PHST- 2024/11/21 12:24 [medline] PHST- 2024/11/21 12:24 [pubmed] PHST- 2024/11/21 09:33 [entrez] AID - 10.23822/EurAnnACI.1764-1489.377 [doi] PST - aheadofprint SO - Eur Ann Allergy Clin Immunol. 2024 Nov 21. doi: 10.23822/EurAnnACI.1764-1489.377. PMID- 39569655 OWN - NLM STAT- MEDLINE DCOM- 20241129 LR - 20260528 IS - 1525-6073 (Electronic) IS - 0742-0528 (Linking) VI - 41 IP - 11 DP - 2024 Nov TI - Using actigraphy to assess chronotype: Simpler is better. PG - 1469-1479 LID - 10.1080/07420528.2024.2428196 [doi] AB - Actigraphy provides a unique method for objectively measuring sleep activity patterns, but confusion remains about how to use actigraphy data to determine chronotype. To determine the most suitable parameter, this study made a systematic comparison of actigraphy-derived parameters: the average midpoint of sleep of all record days (aMS-acti), cosine parameter (Bathyphase), and non-parametric parameter (L5-mid) in terms of the consistency with subjective chronotype parameters, test-retest reliability, and external validity. More importantly, we proposed multiple Munich Chronotype Questionnaire (MCTQ)-based actigraphy parameters: considering the difference between weekday (MSW-acti) with weekends (MSF-acti) and the sleep debt (MSFsc-acti). The study collected 5 days of actigraphy and scale data from 1,055 young adults, 138 of whom participated in the retest 2 years later. The results showed that, in terms of consistency with subjective chronotype, aMS-acti generally performed better than other actigraphy parameters. In addition, aMS-acti had the highest test-retest reliability and was more closely related to the Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), and Self-Rating Depression Scale (SDS). The results suggest that the simplest parameter (aMS-acti) is superior to traditional cosine and non-parametric parameters and MCTQ-derived parameters for short-term assessment of chronotype. FAU - Wei, Yuxian AU - Wei Y AD - Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, Chongqing, China. AD - Key Laboratory of Cognition and Personality, Ministry of Education, Southwest University, Chongqing, China. FAU - Wang, Shuo AU - Wang S AD - Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, Chongqing, China. AD - Key Laboratory of Cognition and Personality, Ministry of Education, Southwest University, Chongqing, China. FAU - Wang, Wendong AU - Wang W AD - Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, Chongqing, China. AD - Key Laboratory of Cognition and Personality, Ministry of Education, Southwest University, Chongqing, China. FAU - Lei, Xu AU - Lei X AD - Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, Chongqing, China. AD - Key Laboratory of Cognition and Personality, Ministry of Education, Southwest University, Chongqing, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241121 PL - England TA - Chronobiol Int JT - Chronobiology international JID - 8501362 SB - IM MH - Humans MH - *Actigraphy/methods MH - Male MH - Female MH - *Circadian Rhythm/physiology MH - *Sleep/physiology MH - Surveys and Questionnaires MH - Young Adult MH - Adult MH - Reproducibility of Results MH - Adolescent MH - Time Factors MH - Sleep Quality MH - Chronotype OTO - NOTNLM OT - Actigraphy OT - Munich Chronotype Questionnaire OT - chronotype OT - circadian rhythm OT - midpoint of sleep EDAT- 2024/11/21 12:25 MHDA- 2024/11/29 06:22 CRDT- 2024/11/21 06:32 PHST- 2024/11/29 06:22 [medline] PHST- 2024/11/21 12:25 [pubmed] PHST- 2024/11/21 06:32 [entrez] AID - 10.1080/07420528.2024.2428196 [doi] PST - ppublish SO - Chronobiol Int. 2024 Nov;41(11):1469-1479. doi: 10.1080/07420528.2024.2428196. Epub 2024 Nov 21. PMID- 39569560 OWN - NLM STAT- MEDLINE DCOM- 20241121 LR - 20260923 IS - 1365-2214 (Electronic) IS - 0305-1862 (Print) IS - 0305-1862 (Linking) VI - 50 IP - 6 DP - 2024 Nov TI - Associations Between Childcare Physical Activity and Sedentary Time and Early Childhood Developmental Outcomes: A Compositional and Isotemporal Substitution Analysis. PG - e70011 LID - 10.1111/cch.70011 [doi] LID - e70011 AB - BACKGROUND: Physical activity and sedentary time are independently associated with health and developmental outcomes in preschool children. However, the integrated nature of these behaviours on early life outcomes, particularly during childcare hours, is currently understudied. As such, the aim of this study was to examine the association between preschool children's physical activity and sedentary time during childcare and various developmental outcomes (psychosocial, cognitive and fundamental movement skills). METHODS: A total of 107 preschool children (M(age): 41 +/- 6 months) recruited from London, Canada, wore ActiGraph wGT3X-BT accelerometers during childcare hours to measure their sedentary time, light intensity physical activity (LPA) and moderate-to-vigorous intensity physical activity (MVPA). Developmental outcomes, including psychosocial health (internalising, externalising, prosocial behaviour), indicators of cognitive development (memory, inhibitory control) and fundamental movement skills (locomotor control, object control, total fundamental movement), were assessed using validated tools. Compositional regression and isotemporal substitution models were estimated to examine how movement compositions in childcare were associated with developmental outcomes. RESULTS: Engaging in more MVPA relative to LPA and sedentary time was associated with fewer internalising symptoms and better total fundamental movement skills and object control skills, whilst spending more time in LPA relative to MVPA and sedentary time was associated with more internalising symptoms and worse object control skills. Isotemporal substitution models suggested that theoretically increasing sedentary time or engaging in MVPA at the expense of time engaging in LPA during childcare is associated with lower internalising symptoms. CONCLUSION: The findings of this study provide preliminary evidence that engaging in MVPA during childcare, at the expense of time in LPA or sedentary time, is associated with children's fundamental movement skills and psychosocial development. Further longitudinal research is required, with larger samples of young children, to assess the mechanisms through which childcare movement behaviour compositions may interact with developmental outcomes, including contextualising both sedentary time and LPA. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT05359536. CI - (c) 2024 The Author(s). Child: Care, Health and Development published by John Wiley & Sons Ltd. FAU - Phillips, Sophie M AU - Phillips SM AUID- ORCID: 0000-0003-4140-8013 AD - Child Health and Physical Activity Laboratory, School of Occupational Therapy, Western University, London, Ontario, Canada. FAU - Bourke, Matthew AU - Bourke M AD - Child Health and Physical Activity Laboratory, School of Occupational Therapy, Western University, London, Ontario, Canada. AD - Health and Wellbeing Centre for Research Innovation, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia. FAU - Bruijns, Brianne A AU - Bruijns BA AD - Child Health and Physical Activity Laboratory, School of Occupational Therapy, Western University, London, Ontario, Canada. FAU - Vanderloo, Leigh AU - Vanderloo L AD - Child Health and Physical Activity Laboratory, School of Occupational Therapy, Western University, London, Ontario, Canada. AD - ParticipACTION, Toronto, Ontario, Canada. FAU - Loh, Aidan AU - Loh A AD - Child Health and Physical Activity Laboratory, School of Occupational Therapy, Western University, London, Ontario, Canada. FAU - Saravanamuttoo, Kendall AU - Saravanamuttoo K AUID- ORCID: 0000-0002-8700-5386 AD - Child Health and Physical Activity Laboratory, School of Occupational Therapy, Western University, London, Ontario, Canada. FAU - Tucker, Patricia AU - Tucker P AUID- ORCID: 0000-0002-8392-9418 AD - Child Health and Physical Activity Laboratory, School of Occupational Therapy, Western University, London, Ontario, Canada. LA - eng SI - ClinicalTrials.gov/NCT05359536 GR - Western University-CIHR Seed Grant/ PT - Journal Article PL - England TA - Child Care Health Dev JT - Child: care, health and development JID - 7602632 SB - IM MH - Child, Preschool MH - Female MH - Humans MH - Male MH - Accelerometry MH - Child Behavior/physiology MH - Child Care MH - Child Day Care Centers MH - *Child Development/physiology MH - Cognition/physiology MH - *Exercise/physiology MH - London MH - Motor Skills/physiology MH - *Sedentary Behavior MH - Cross-Sectional Studies MH - Randomized Controlled Trials as Topic PMC - PMC11579959 OTO - NOTNLM OT - childcare OT - compositional data analysis OT - physical activity OT - preschool OT - sedentary time COIS- The authors declare no conflicts of interest. EDAT- 2024/11/21 06:20 MHDA- 2024/11/21 06:21 PMCR- 2024/11/21 CRDT- 2024/11/21 05:33 PHST- 2024/10/02 00:00 [revised] PHST- 2024/05/30 00:00 [received] PHST- 2024/10/31 00:00 [accepted] PHST- 2024/11/21 06:21 [medline] PHST- 2024/11/21 06:20 [pubmed] PHST- 2024/11/21 05:33 [entrez] PHST- 2024/11/21 00:00 [pmc-release] AID - CCH70011 [pii] AID - 10.1111/cch.70011 [doi] PST - ppublish SO - Child Care Health Dev. 2024 Nov;50(6):e70011. doi: 10.1111/cch.70011. PMID- 39569425 OWN - NLM STAT- MEDLINE DCOM- 20250617 LR - 20250617 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) VI - 31 IP - 2 DP - 2025 Jun TI - Creatine and sleep habits and disorders in the general population aged 16 years and over: NHANES 2007-2008. PG - 369-376 LID - 10.1177/02601060241299958 [doi] AB - Background: Preclinical studies have suggested that dietary creatine may affect sleep quality yet no studies have explored the potential association between creatine consumption and sleep patterns or disorders in the general population. Aim: This cross-sectional study aims to examine the association between creatine consumption and sleep habits and disorders among individuals aged 16 years and older, using data from the 2007-2008 National Health and Nutrition Examination Survey (NHANES). Methods: The analysis included 5988 individuals (50.5% females) with a mean age of 47.4 +/- 19.5 years. Daily creatine intake was assessed through individual in-person 24-h food recall interviews, categorizing respondents into two groups: those with suboptimal creatine intake (<1.00 g per day) and those meeting recommended intake (dietary creatine >/= 1.00 g per day). Sleep was evaluated during household interviews using questions on sleep habits and disorders from the NHANES Sleep Disorders component. Results: The average daily creatine intake among participants was 0.88 +/- 0.85 g (95% CI, 0.86 to 0.90), while the mean nightly sleep duration was 6.8 +/- 1.5 h (95% CI, 6.8 to 6.9). Additionally, 1331 respondents (22.2%) reported consulting a doctor or health professional for sleep-related issues. Participants with suboptimal creatine intake had a significantly higher prevalence of trouble sleeping compared to those consuming recommended amounts (23.7% vs 19.3%; P < 0.01), with an odds ratio of 1.30 (95% CI: 1.13 to 1.48) for experiencing sleep disturbances. However, the prevalence of more severe sleep disorders did not differ significantly between the two creatine sub-populations (P > 0.05). Conclusion: Our findings suggest that participants meeting recommended creatine intake levels had a reduced risk of experiencing mild sleeping difficulties. These findings may serve as a basis for future interventional studies aimed at validating and confirming the potential benefits of dietary creatine in the field of sleep medicine. FAU - Baltic, Sonja AU - Baltic S AD - Applied Bioenergetics Lab, Faculty of Sport and PE, University of Novi Sad, Novi Sad, Serbia. RINGGOLD: 84981 FAU - Grasaas, Erik AU - Grasaas E AD - Teacher Education Unit, University of Agder, Kristiansand, Norway. RINGGOLD: 4343 FAU - Ostojic, Sergej M AU - Ostojic SM AUID- ORCID: 0000-0002-7270-2541 AD - Applied Bioenergetics Lab, Faculty of Sport and PE, University of Novi Sad, Novi Sad, Serbia. RINGGOLD: 84981 AD - Department of Nutrition and Public Health, University of Agder, Kristiansand, Norway. RINGGOLD: 4343 AD - Faculty of Health Sciences, University of Pecs, Pecs, Hungary. LA - eng PT - Journal Article DEP - 20241121 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 RN - MU72812GK0 (Creatine) SB - IM MH - Humans MH - *Creatine/administration & dosage MH - Male MH - Female MH - Middle Aged MH - Cross-Sectional Studies MH - Nutrition Surveys MH - Adult MH - Adolescent MH - *Sleep Wake Disorders/epidemiology MH - Young Adult MH - Aged MH - *Diet MH - *Sleep/drug effects MH - Sleep Quality OTO - NOTNLM OT - NHANES OT - creatine OT - diet OT - sleep OT - sleep disorder COIS- Declaration of conflicting interestsThe authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: SMO serves as a member of the Scientific Advisory Board on Creatine in Health and Medicine (AlzChem LLC). SMO co-owns patent "Supplements Based on Liquid Creatine" at the European Patent Office (WO2019150323 A1) and patent application "Composition Comprising Creatine for Use in Telomere Lengthening" at the U.S. Patent and Trademark Office (# 63/608,850). SMO has received research support related to creatine during the past 36 months from the Serbian Ministry of Education, Science, and Technological Development; Provincial Secretariat for Higher Education and Scientific Research; AlzChem GmbH; ThermoLife International; and Hueston Hennigan LLP. SMO does not own stocks and shares in any organization. SB and EG declare no known competing financial interests or personal relationships that could have appeared to influence the authorship of this paper. EDAT- 2024/11/21 06:21 MHDA- 2025/06/17 14:36 CRDT- 2024/11/21 04:52 PHST- 2025/06/17 14:36 [medline] PHST- 2024/11/21 06:21 [pubmed] PHST- 2024/11/21 04:52 [entrez] AID - 10.1177/02601060241299958 [doi] PST - ppublish SO - Nutr Health. 2025 Jun;31(2):369-376. doi: 10.1177/02601060241299958. Epub 2024 Nov 21. PMID- 39565621 OWN - NLM STAT- MEDLINE DCOM- 20241120 LR - 20260923 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 7 IP - 11 DP - 2024 Nov 4 TI - Trends in Postpartum Depression by Race, Ethnicity, and Prepregnancy Body Mass Index. PG - e2446486 LID - 10.1001/jamanetworkopen.2024.46486 [doi] LID - e2446486 AB - IMPORTANCE: Postpartum depression (PPD) poses significant risks to maternal and child health. Understanding temporal trends is crucial for evaluating prevalence and identifying populations at risk. OBJECTIVE: To evaluate recent trends in PPD and assess how these trends are associated with race, ethnicity, and prepregnancy body mass index (BMI). DESIGN, SETTING, AND PARTICIPANTS: A serial, cross-sectional analysis using data from the Kaiser Permanente Southern California (KPSC) electronic health records (EHRs), with live and stillbirths at 20 or more weeks of gestation who were KPSC members at the time of delivery between 2010 and 2021. Data were analyzed from July 2022 to August 2023. EXPOSURES: Self-reported race, ethnicity, and recorded prepregnancy BMI. MAIN OUTCOME MEASURES: PPD cases were identified using validated diagnostic codes and prescription records within 12 months postpartum in the KPSC EHRs. Patients with an Edinburgh Postnatal Depression Scale score of 10 or more within 6 months postpartum were further evaluated by a mental health specialist for formal PPD diagnosis. RESULTS: In this study of 442 308 pregnancies, the median (IQR) maternal age at delivery was 31 (27-34) years. The cohort was racially and ethnically diverse, with 62 860 individuals (14.2%) identifying as Asian/Pacific Islander, 231 837 (52.4%) as Hispanic, 33 207 (7.5%) as non-Hispanic Black, 108 201 (24.5%) as non-Hispanic White, 5903 (1.3%) as multiple or other, and 300 (0.1%) unknown. PPD prevalence doubled over the study period, increasing from 9.4% in 2010 to 19.0% in 2021. The largest increases were observed among Asian and Pacific Islander participants (280% increase) and non-Hispanic Black participants (140% increase). PPD rates increased across all BMI categories, particularly among individuals with obesity (class I) and morbid obesity (class II/III). CONCLUSIONS AND RELEVANCE: In this cross-sectional study, PPD diagnosis increased significantly across all racial and ethnic groups and BMI categories over the past decade. While rising PPD may reflect improved screening and diagnosis practices, the persistently high rates highlight the need to develop and implement interventions to prevent the condition while expanding efforts to mitigate the impact of PPD on maternal and child health. FAU - Khadka, Nehaa AU - Khadka N AD - Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena. FAU - Fassett, Michael J AU - Fassett MJ AD - Obstetrics and Gynecology, Kaiser Permanente, Los Angeles, California. FAU - Oyelese, Yinka AU - Oyelese Y AD - Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts. FAU - Mensah, Nana A AU - Mensah NA AD - Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena. AD - Now with Brigham Young University, Provo, Utah. FAU - Chiu, Vicki Y AU - Chiu VY AD - Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena. FAU - Yeh, Meiyu AU - Yeh M AD - Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena. FAU - Peltier, Morgan R AU - Peltier MR AD - Department of Psychiatry and Behavioral Health, Jersey Shore University Medical Center, Neptune, New Jersey. AD - Department of Psychiatry and Behavioral Health, Hackensack-Meridian School of Medicine, Nutley, New Jersey. FAU - Getahun, Darios AU - Getahun D AD - Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241104 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Humans MH - Female MH - *Depression, Postpartum/epidemiology/ethnology/diagnosis MH - Cross-Sectional Studies MH - Adult MH - *Body Mass Index MH - California/epidemiology MH - Pregnancy MH - *Ethnicity/statistics & numerical data MH - Prevalence MH - Racial Groups/statistics & numerical data PMC - PMC11579791 COIS- Conflict of Interest Disclosures: None reported. EDAT- 2024/11/20 12:25 MHDA- 2024/11/20 18:22 PMCR- 2024/11/20 CRDT- 2024/11/20 11:33 PHST- 2024/11/20 18:22 [medline] PHST- 2024/11/20 12:25 [pubmed] PHST- 2024/11/20 11:33 [entrez] PHST- 2024/11/20 00:00 [pmc-release] AID - 2826508 [pii] AID - zoi241319 [pii] AID - 10.1001/jamanetworkopen.2024.46486 [doi] PST - epublish SO - JAMA Netw Open. 2024 Nov 4;7(11):e2446486. doi: 10.1001/jamanetworkopen.2024.46486. PMID- 39565377 OWN - NLM STAT- MEDLINE DCOM- 20250426 LR - 20250517 IS - 1434-4726 (Electronic) IS - 0937-4477 (Print) IS - 0937-4477 (Linking) VI - 282 IP - 2 DP - 2025 Feb TI - Association of adenoid hypertrophy and clinical parameters with preoperative polygraphy in pediatric patients undergoing adenoidectomy. PG - 1075-1084 LID - 10.1007/s00405-024-09071-4 [doi] AB - BACKGROUND: Adenotonsillar hypertrophy is the most frequent cause for obstructive sleep apnea (OSAS) in children. In patients with small tonsils and where adenoid size cannot be assessed, the indication for adenoidectomy often relies on clinical symptoms. However, data on the association of clinical parameters and adenoid hypertrophy with OSAS severity in children undergoing an adenoidectomy is sparse. AIM: To investigate the correlation of patient characteristics, adenoid hypertrophy, and clinical symptoms with OSAS severity in pediatric patients indicated for an adenoidectomy. METHODS: We performed a retrospective chart review of all pediatric patients at our tertiary referral center between 2018 and 2023 who underwent polygraphy (PG) for OSAS diagnostics. Adenoid hypertrophy was assessed as adenoid-choanal ratio (AC-ratio) via nasal endoscopy and clinical symptom score (CS) via physical examination and parental survey. We included all symptomatic children with mild to severe OSAS (apnea-hypopnea index (AHI) >/= 1). Exclusion criteria were obesity according to BMI and/or the presence of systemic diseases. The patients were divided according to age in a preschool and school cohort. Patient characteristics and PG data were compared between both groups. Linear regression analysis was used to investigate the association of AC-ratio, CS and BMI with the AHI. RESULTS: A total of 121 patients were identified of which 81 were included in our study, resulting in 42 and 39 patients from 3-5 and 6-14 years of age, respectively. We observed a significant correlation between CS and BMI (p = 0.026) and the CS and AC-ratio (p < 0.001). Univariable regression analysis showed significant association of the AC-ratio and CS with AHI-score for the total (p < 0.001), the preschool (p < 0.001), and the school cohort (p < 0.001). In multivariable regression analysis, the significant association of AC-ratio and CS remained in the total (p = 0.014; p < 0.001), and the preschool cohort (p = 0.029; p = 0.002). However, only the CS remained as positive predictor in the school cohort. CONCLUSION: AC-ratio and clinical symptoms seem to be reliable predictors for OSAS severity in patients between 3-14 years of age. Moreover, only clinical symptoms were associated with OSAS severity in schoolchildren. Future investigation should contribute to the validation of our results. CI - (c) 2024. The Author(s). FAU - Lein, Alexander AU - Lein A AD - Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. FAU - Altumbabic, Hasan AU - Altumbabic H AD - Department of Otorhinolaryngology, ASA Hospital, Sarajevo, Bosnia and Herzegovina. FAU - Desevic, Miralem AU - Desevic M AD - PHI Eurofarm Center, Sarajevo, Bosnia and Herzegovina. FAU - Baumgartner, Wolf-Dieter AU - Baumgartner WD AD - Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. FAU - Salkic, Almir AU - Salkic A AD - Department of Otorhinolaryngology, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina. FAU - Umihanic, Sekib AU - Umihanic S AD - Department of Otorhinolaryngology, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina. FAU - Ramas, Almedina AU - Ramas A AD - Department of Otorhinolaryngology, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina. FAU - Harcinovic, Alen AU - Harcinovic A AD - Department of Otorhinolaryngology, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina. FAU - Kosec, Andro AU - Kosec A AD - Department of Otorhinolaryngology, Head and Neck Surgery, University Clinical Hospital Center Sestre Milosrdnice, Zagreb, Croatia. FAU - Brkic, Faris F AU - Brkic FF AUID- ORCID: 0000-0002-0770-6677 AD - Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. faris.brkic@meduniwien.ac.at. LA - eng PT - Journal Article DEP - 20241120 PL - Germany TA - Eur Arch Otorhinolaryngol JT - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery JID - 9002937 SB - IM MH - Humans MH - *Adenoids/pathology/surgery MH - Hypertrophy/complications MH - Female MH - Male MH - *Adenoidectomy MH - Retrospective Studies MH - Child MH - *Sleep Apnea, Obstructive/surgery/etiology/diagnosis MH - Child, Preschool MH - Severity of Illness Index MH - Adolescent MH - Polysomnography PMC - PMC11805796 OTO - NOTNLM OT - Adenoidectomy OT - Clinical score OT - OSAS OT - Pediatric OT - Polygraphy COIS- Declarations. Conflict of interests: The other authors declare no conflict of interest related to the publication of this article. Ethical approval: The ethics committee of the Medical University of Tuzla approved this study (No.: 02-09/2-98-3/24). The requirement for written informed consent was waived due to the retrospective study design. Consent for publication: Not applicable. EDAT- 2024/11/20 12:24 MHDA- 2025/02/08 00:30 PMCR- 2024/11/20 CRDT- 2024/11/20 11:13 PHST- 2024/08/16 00:00 [received] PHST- 2024/11/04 00:00 [accepted] PHST- 2025/02/08 00:30 [medline] PHST- 2024/11/20 12:24 [pubmed] PHST- 2024/11/20 11:13 [entrez] PHST- 2024/11/20 00:00 [pmc-release] AID - 10.1007/s00405-024-09071-4 [pii] AID - 9071 [pii] AID - 10.1007/s00405-024-09071-4 [doi] PST - ppublish SO - Eur Arch Otorhinolaryngol. 2025 Feb;282(2):1075-1084. doi: 10.1007/s00405-024-09071-4. Epub 2024 Nov 20. PMID- 39563838 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241121 IS - 2234-8646 (Print) IS - 2234-8840 (Electronic) IS - 2234-8840 (Linking) VI - 27 IP - 6 DP - 2024 Nov TI - Oral Nutrition During Continuous Albuterol for Pediatric Critical Asthma: A Matched Cohort Study. PG - 364-371 LID - 10.5223/pghn.2024.27.6.364 [doi] AB - PURPOSE: The practice of withholding oral nutrition for children hospitalized for critical asthma receiving continuous albuterol is not evidence based. We sought to characterize oral nutrition practices in this population and estimate the frequency of aspiration-related respiratory failure. METHODS: We performed a single-center retrospective, matched cohort study of children 3-17 years of age admitted to a pediatric intensive care unit from Oct 2020 to May 2023 for critical asthma receiving continuous albuterol. Cases provided oral nutrition were matched 1:2 to controls withheld nutrition by age and National Heart Lung and Blood Institute asthma severity classification. The primary outcome was aspiration-related respiratory failure defined as any respiratory support escalation following observed aspiration. Descriptive data included demographics, anthropometrics, pediatric asthma severity scores, adjunct asthma interventions, continuous albuterol duration, mortality, and length of stay. RESULTS: Of 36 cases and 72 matched controls, the mean age was 9.1+/-3.9 years and 66.7% had moderate-severe persistent asthma. Cases and controls had comparable anthropometrics and admission pediatric asthma severity scores. No aspiration-related respiratory failure events were observed even among those receiving nutrition concurrent to noninvasive ventilation. Compared to controls, cases experienced a longer continuous albuterol duration (median: 1.1 [interquartile range: 0.7-1.8] versus 0.7 [interquartile range: 0.3-1.3] days, p<0.001). No differences in length of stay, adjunct interventions, endotracheal intubation rates, and mortality were observed between cases and controls. CONCLUSION: For children hospitalized for critical asthma, oral nutrition during continuous nebulized albuterol appeared well tolerated. While prospective validation is required, the practice of withholding oral nutrition for continuous albuterol administration may be unwarranted. CI - Copyright (c) 2024 by The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition. FAU - Root, Maya Antionette AU - Root MA AUID- ORCID: 0009-0005-4012-0503 AD - Lincoln Memorial University-DeBusk College of Osteopathic Medicine, Harrogate, TN, USA. FAU - Pavlich, Carolyn Maria Ibrahim AU - Pavlich CMI AUID- ORCID: 0009-0009-6504-3208 AD - Division of Pediatric Critical Care Medicine, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA. FAU - Sochet, Anthony Alexander AU - Sochet AA AUID- ORCID: 0000-0002-6290-4975 AD - Division of Pediatric Critical Care Medicine, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA. AD - Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA. FAU - Roberts, Alexa Rae AU - Roberts AR AUID- ORCID: 0009-0002-0600-6705 AD - Division of Pediatric Critical Care Medicine, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA. FAU - Russi, Brett Walter AU - Russi BW AUID- ORCID: 0009-0006-5304-3057 AD - Division of Pediatric Critical Care Medicine, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA. AD - Division of Pediatric Critical Care Medicine, University of South Florida Morsani College of Medicine, Tampa, FL, USA. LA - eng PT - Journal Article DEP - 20241105 PL - Korea (South) TA - Pediatr Gastroenterol Hepatol Nutr JT - Pediatric gastroenterology, hepatology & nutrition JID - 101590471 PMC - PMC11570357 OTO - NOTNLM OT - Enteral nutrition OT - Respiratory aspiration OT - Status asthmaticus COIS- Conflict of Interest: The authors have no financial conflicts of interest. EDAT- 2024/11/20 11:04 MHDA- 2024/11/20 11:05 PMCR- 2024/11/01 CRDT- 2024/11/20 04:25 PHST- 2024/05/24 00:00 [received] PHST- 2024/10/01 00:00 [accepted] PHST- 2024/11/20 11:05 [medline] PHST- 2024/11/20 11:04 [pubmed] PHST- 2024/11/20 04:25 [entrez] PHST- 2024/11/01 00:00 [pmc-release] AID - 10.5223/pghn.2024.27.6.364 [doi] PST - ppublish SO - Pediatr Gastroenterol Hepatol Nutr. 2024 Nov;27(6):364-371. doi: 10.5223/pghn.2024.27.6.364. Epub 2024 Nov 5. PMID- 39563298 OWN - NLM STAT- MEDLINE DCOM- 20241120 LR - 20241122 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 Nov 19 TI - To eat or not to eat oats: factors associated with oats consumption using the I-Change model. PG - 3215 LID - 10.1186/s12889-024-20044-4 [doi] LID - 3215 AB - A suboptimal diet is responsible for more deaths worldwide than any other risk. A dietary factor that needs more attention is whole-grain consumption because of its proven health, nutritional, and environmental benefits. Despite these benefits, the daily whole-grain and dietary fibre intake by Dutch residents is low and the reasons for this low consumption are unknown. This study analysed the facilitating and hindering factors associated with (non) oat consumption using the Integrated Change Model (ICM). It compared which factors distinguished oat consumers from moderate and low-oat consumers using a cross-sectional, quantitative study design. The questionnaire used in the quantitative study was based on the results a qualitative study that validated the findings identified in the literature and previous ICM studies. Data was collected using an online survey (Qualtrics). In both studies, the sample of participants included individuals age > 18, of both genders residents in the Netherlands without an allergy to oats, and who read or speak fluently Dutch or English. In total, 299 residents were included in the study. The results indicated that non-oat consumers were less health-conscious, had limited awareness of their dietary behaviours, possessed less knowledge, and were less aware of the severity and susceptibility to various health conditions, such as high cholesterol. They also received fewer prompts to consume oats, were less convinced of the rational and emotional benefits of oats, experienced less social support, reported more obstacles, and had lower self-efficacy regarding oat consumption. The Integrated Change Model (ICM) explained 55% of the variance in intention and 38% in behaviour. Consequently, efforts to promote oat consumption among Dutch adults should address these factors to enhance awareness, increase motivation, and facilitate actions to boost oat intake. CI - (c) 2024. The Author(s). FAU - Van Kol, S AU - Van Kol S AD - Faculty Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands. FAU - van der Horst, H C AU - van der Horst HC AD - Keep Food Simple, Driebergen-Rijsenburg, The Netherlands. FAU - de Vries, H AU - de Vries H AD - CAPHRI School for Public Health and Primary Care, Faculty of Health, Medicine and Life Sciences, Maastricht University, P.O. Box 616, Maastricht, 6200 MD, The Netherlands. hein.devries@maastrichtuniversity.nl. LA - eng PT - Journal Article DEP - 20241119 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Male MH - Female MH - *Avena MH - Cross-Sectional Studies MH - Adult MH - Middle Aged MH - Netherlands MH - Surveys and Questionnaires MH - Young Adult MH - Aged MH - Feeding Behavior/psychology MH - Health Knowledge, Attitudes, Practice MH - Diet/statistics & numerical data MH - Adolescent PMC - PMC11577757 OTO - NOTNLM OT - Attitude OT - Cognizance OT - Consumer behaviour OT - Oats OT - Predisposing factors OT - Risk perception OT - Self-efficacy OT - Social norms OT - The Integrated Change Model (ICM) COIS- Declarations Ethics approval and consent to participate Ethical approval for this study was sought and obtained from the the Faculty Research Ethics Committee (FHML-REC) at Maastricht University. The project was considered under the case number: FHML-REC/2023/057. All methods were performed according to the relevant guidelines and regulations. Informed consent from all participants for participation was obtained as described in the Method section of this paper. Consent for publication Not applicable. Competing interests The authors declare no competing interests. EDAT- 2024/11/20 11:04 MHDA- 2024/11/20 11:05 PMCR- 2024/11/19 CRDT- 2024/11/20 03:07 PHST- 2023/05/31 00:00 [received] PHST- 2024/09/11 00:00 [accepted] PHST- 2024/11/20 11:05 [medline] PHST- 2024/11/20 11:04 [pubmed] PHST- 2024/11/20 03:07 [entrez] PHST- 2024/11/19 00:00 [pmc-release] AID - 10.1186/s12889-024-20044-4 [pii] AID - 20044 [pii] AID - 10.1186/s12889-024-20044-4 [doi] PST - epublish SO - BMC Public Health. 2024 Nov 19;24(1):3215. doi: 10.1186/s12889-024-20044-4. PMID- 39563102 OWN - NLM STAT- MEDLINE DCOM- 20250630 LR - 20260827 IS - 1464-5165 (Electronic) IS - 0963-8288 (Linking) VI - 47 IP - 14 DP - 2025 Jul TI - Construct validity and reliability of the 2-minute step test in patients with lumbar spinal stenosis. PG - 3708-3713 LID - 10.1080/09638288.2024.2428824 [doi] AB - AIM: This study aimed to investigate the validity and reliability of the 2-Minute Step Test (2MST) in patients with lumbar spinal stenosis (LSS). METHOD: This cross-sectional study involved 55 volunteers, aged 18-80, diagnosed with lumbar spinal stenosis. The participants were assessed using the 2MST, the 2-Minute Walk Test (2MWT), the 6-Minute Walk Test (6MWT), the Visual Analogue Scale (VAS), and the Oswestry Disability Index (ODI). To evaluate the reliability of the 2MST, test-retest reliability was determined by administering the 2MST again after a 7-day interval. The reliability analysis included the intraclass correlation coefficient (ICC) with a 95% confidence interval (CI), standard error of measurement (SEM), and minimum detectable change at the 95% confidence level (MDC(95)). For concurrent validity, the correlations of the 2MST with the 2MWT, 6MWT, and ODI were assessed. RESULTS: The 2MST exhibited excellent test-retest reliability (ICC = 0.94, SEM = 5.56, MDC(95)=15.41) in LSS patients. Additionally, the 2MST showed significant correlations with the 2MWT (r = 0.842, p < 0.001), 6MWT (r = 0.819, p < 0.001), and ODI score (r = -0.722, p < 0.001). CONCLUSION: This study demonstrated that the 2MST is a valid and reliable tool for assessing exercise capacity in individuals with LSS. CLINICALTRIALS.GOV ID: NCT06060821. FAU - Paker, Nurdan AU - Paker N AUID- ORCID: 0000-0001-8957-1843 AD - Department of Physical Therapy and Rehabilitation, Istanbul Physical Medicine and Rehabilitation Hospital, University of Health Sciences, Istanbul, Turkey. FAU - Sirin Ahisha, Busra AU - Sirin Ahisha B AUID- ORCID: 0000-0001-8519-1747 AD - Department of Physical Therapy and Rehabilitation, Istanbul Physical Medicine and Rehabilitation Hospital, University of Health Sciences, Istanbul, Turkey. FAU - Kesiktas, Nur AU - Kesiktas N AUID- ORCID: 0000-0002-3937-9973 AD - Department of Physical Therapy and Rehabilitation, Istanbul Physical Medicine and Rehabilitation Hospital, University of Health Sciences, Istanbul, Turkey. FAU - Bugdayci, Nazli Derya AU - Bugdayci ND AUID- ORCID: 0000-0003-1906-4568 AD - Department of Physical Therapy and Rehabilitation, Istanbul Physical Medicine and Rehabilitation Hospital, University of Health Sciences, Istanbul, Turkey. FAU - Soluk Ozdemir, Yelda AU - Soluk Ozdemir Y AUID- ORCID: 0000-0002-3361-6093 AD - Department of Physical Therapy and Rehabilitation, Istanbul Physical Medicine and Rehabilitation Hospital, University of Health Sciences, Istanbul, Turkey. LA - eng SI - ClinicalTrials.gov/NCT06060821 PT - Journal Article PT - Observational Study PT - Validation Study DEP - 20241119 PL - England TA - Disabil Rehabil JT - Disability and rehabilitation JID - 9207179 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - Cross-Sectional Studies MH - Disability Evaluation MH - *Exercise Test/methods MH - *Lumbar Vertebrae MH - Reproducibility of Results MH - *Spinal Stenosis/physiopathology/rehabilitation MH - *Walk Test MH - Walking/physiology OAB - The 2-Minute Step Test (2MST) is a valid and reliable method for assessing exercise capacity in patients with lumbar spinal stenosis (LSS).The 2MST is a practical, low-cost test that does not require equipment and can be easily administered in small clinical spaces, making it a convenient tool for functional capacity assessments.Clinicians should consider using the 2MST to monitor functional improvements and guide rehabilitation interventions for patients with LSS. OABL- eng OTO - NOTNLM OT - Spinal stenosis OT - exercise test OT - physical fitness EDAT- 2024/11/20 11:04 MHDA- 2025/07/01 04:52 CRDT- 2024/11/20 02:12 PHST- 2025/07/01 04:52 [medline] PHST- 2024/11/20 11:04 [pubmed] PHST- 2024/11/20 02:12 [entrez] AID - 10.1080/09638288.2024.2428824 [doi] PST - ppublish SO - Disabil Rehabil. 2025 Jul;47(14):3708-3713. doi: 10.1080/09638288.2024.2428824. Epub 2024 Nov 19. PMID- 39562808 OWN - NLM STAT- MEDLINE DCOM- 20241120 LR - 20241123 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Nov 19 TI - The association between dietary obesity-prevention score (DOS) and polycystic ovary syndrome: a case-control study. PG - 28618 LID - 10.1038/s41598-024-80238-z [doi] LID - 28618 AB - Polycystic ovary syndrome (PCOS) is one of the most prevalent obesity-related diseases in women of reproductive age. Linkage between diet and PCOS are still controversial. Dietary obesity prevention score (DOS) is one of the new indicators of diet evaluation which have been previously linked to obesity. To the best of our knowledge, this study was the first to investigate the relationship between DOS and PCOS. In this case-control study, 100 newly diagnosed women with PCOS and 100 age-matched women without PCOS were assayed from clinics affiliated to Kashan university of medical sciences, Kashan, Iran. A validated semi-quantitative food frequency questionnaire was used to evaluate food intakes. DOS was calculated based on previous published guideline. Anthropometric measurements were carefully measured by a trained nutritionist. A 10-houres fasting plasma blood sample was collected for all participants. Fasting blood sugar (FBS), triglyceride (TG), total cholesterol (CHOL), High density lipoprotein (HDL), Low density lipoprotein (LDL) and C - reactive protein (CRP) were measured based on laboratory methods. The mean age and BMI of study participants was 23.6 year and 24.9 kg/m(2) respectively. After adjustment for potential confounders, adherence to DOS score was inversely associated with CRP levels. People in the top tertile of DOS had lower CRP level compared to people in the bottom tertile (3.71 compared to 4.48 mg/dl) (P = 0.04). In addition, participant in the top tertile of DOS had marginally significant higher level of FBS compared to participants in the bottom tertile (92.3 vs. 88.9 mg/dl, P = 0.051). After adjustment for all confounding factors people in the highest tertile of DOS had a 46% non-significant lower odds for PCOS compared to people in the lowest tertile (95% CI: 0.23-1.25; P-trend = 0.15). In the present study, an inverse significant association was seen between adherence to DOS and inflammation. However, no significant relationship was observed between DOS and odds of having PCOS. Further longitudinal studies are suggested to investigate the association between DOS and PCOS. CI - (c) 2024. The Author(s). FAU - Mahabady, Masoumeh AU - Mahabady M AD - Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran. FAU - Zolfaghari, Hamid AU - Zolfaghari H AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. FAU - Samimi, Mansoreh AU - Samimi M AD - Department of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran. FAU - Gilasi, Hamidreza AU - Gilasi H AD - Department of Public Health and Biostatistics, Faculty of Health, Kashan University of Medical Sciences, Kashan, Iran. FAU - Sharifi, Nasrin AU - Sharifi N AD - Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran. FAU - Aminianfar, Azadeh AU - Aminianfar A AD - Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran. aaminianfar@gmail.com. AD - Department of Nutrition, School of Medicine, Kashan University of Medical Sciences, Kashan, P.O. Box 8715981151, Iran. aaminianfar@gmail.com. LA - eng PT - Journal Article DEP - 20241119 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 9007-41-4 (C-Reactive Protein) RN - 0 (Blood Glucose) RN - 0 (Triglycerides) SB - IM MH - Humans MH - *Polycystic Ovary Syndrome/blood MH - Female MH - Case-Control Studies MH - *Obesity/epidemiology/blood MH - Adult MH - Young Adult MH - Iran/epidemiology MH - Diet MH - Body Mass Index MH - C-Reactive Protein/analysis/metabolism MH - Blood Glucose/analysis MH - Adolescent MH - Triglycerides/blood PMC - PMC11576844 OTO - NOTNLM OT - Case-control study OT - Diet OT - Dietary obesity-prevention score OT - Polycystic ovary syndrome COIS- Declarations Competing interests The authors declare no competing interests. EDAT- 2024/11/20 10:20 MHDA- 2024/11/20 10:21 PMCR- 2024/11/19 CRDT- 2024/11/20 00:48 PHST- 2024/07/27 00:00 [received] PHST- 2024/11/18 00:00 [accepted] PHST- 2024/11/20 10:21 [medline] PHST- 2024/11/20 10:20 [pubmed] PHST- 2024/11/20 00:48 [entrez] PHST- 2024/11/19 00:00 [pmc-release] AID - 10.1038/s41598-024-80238-z [pii] AID - 80238 [pii] AID - 10.1038/s41598-024-80238-z [doi] PST - epublish SO - Sci Rep. 2024 Nov 19;14(1):28618. doi: 10.1038/s41598-024-80238-z. PMID- 39556539 OWN - NLM STAT- MEDLINE DCOM- 20241118 LR - 20260909 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 11 DP - 2024 TI - Prevalence and influencing factors with knowledge, attitude, and practice toward anemia among school-going adolescent girls in rural Bangladesh. PG - e0313071 LID - 10.1371/journal.pone.0313071 [doi] LID - e0313071 AB - BACKGROUND: Anemia is a major public health concern; however, research on anemia and its contributing variables is scarce. To address the gap, we investigated the prevalence and associated factors of anemia in school-aged adolescent girls in rural Bangladesh. METHODS: We conducted a cross-sectional study in two secondary schools at Chandpur, Bangladesh, from January to April 2022. We randomly selected 422 adolescent girls based on prevalence rates from existing research to ensure reliable estimates and a robust study representation. We performed interviews with a semi-structured questionnaire after receiving ethical permission and written informed consent. In addition, physical examination and anthropometric measurements were done, followed by blood testing to identify anemia. Blood hemoglobin was measured using a spectrophotometric method, and quality control was ensured by validated results with control samples. Univariate with multiple logistic regression was employed for analysis to find the association between anemia and all other variables that were adjusted to control the potential effect of confounding variables. RESULTS: The overall prevalence of anemia was 37.7% (mild- 33.8% and moderate- 3.9%). In the univariate analysis having a working mother (OR 3.84; 95% CI 1.31-11.26), undernutrition (OR 2.40; 95% CI 1.27-4.52), and irregular lunch consumption (OR 2.15; 95% CI 1.00-4.60) were associated with anemia. Conversely, being a user of a slab latrine (OR 0.61; 95% CI 0.40-0.93) and not weekly consumption of pure milk (OR 0.62; 95% CI 0.41-0.92) were negatively associated with anemia. In multivariate logistic regression analysis, associated factors for prevalent anemia were working mother [adjusted odds ratio (aOR) 7.65; 95% CI 1.97-29.50], slab latrine user (aOR 0.46; 95% CI 0.26-0.79), and irregular lunch consumption (aOR 2.92; 95% CI 1.21-7.03). CONCLUSION: The prevalence of anemia among adolescent girls in rural Bangladesh remains high with undernutrition. Anemia is associated with working mothers, slab latrine users, and irregular lunch consumers within the studied population.' Thus, policymakers may promote school-based nutritional education and lunch programs with iron supplementation and improve sanitary facilities. CI - Copyright: (c) 2024 Rahman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Rahman, Md Jiaur AU - Rahman MJ AUID- ORCID: 0000-0002-2027-2893 AD - Department of Health Science, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. FAU - Rahman, Md Moshiur AU - Rahman MM AUID- ORCID: 0000-0002-5475-986X AD - Department of Health Science, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. FAU - Sarker, Mohammad Habibur Rahman AU - Sarker MHR AD - Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. FAU - Kakehashi, Masayuki AU - Kakehashi M AD - Department of Health Science, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. FAU - Tsunematsu, Miwako AU - Tsunematsu M AD - Department of Health Science, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. FAU - Ali, Mohammad AU - Ali M AD - Department of Medicine, Comilla Medical College, Comilla, Bangladesh. FAU - Ahmed, Ashir AU - Ahmed A AD - Department of Advanced Information Technology, Graduate School of Information Science and Electrical Engineering, Kyushu University, Fukuoka, Japan. FAU - Hawlader, Mohammad Delwer Hossain AU - Hawlader MDH AD - Department of Public Health, School of Health and Life Sciences, North South University, Dhaka, Bangladesh. FAU - Shimpuku, Yoko AU - Shimpuku Y AUID- ORCID: 0000-0001-7531-7019 AD - Department of Health Science, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241118 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Bangladesh/epidemiology MH - Female MH - Adolescent MH - *Anemia/epidemiology MH - *Rural Population MH - Prevalence MH - Cross-Sectional Studies MH - *Health Knowledge, Attitudes, Practice MH - Child MH - Schools MH - Surveys and Questionnaires MH - Risk Factors PMC - PMC11573218 COIS- The authors have declared that no competing interests exist. EDAT- 2024/11/18 18:23 MHDA- 2024/11/19 00:22 PMCR- 2024/11/18 CRDT- 2024/11/18 13:33 PHST- 2023/09/06 00:00 [received] PHST- 2024/10/17 00:00 [accepted] PHST- 2024/11/19 00:22 [medline] PHST- 2024/11/18 18:23 [pubmed] PHST- 2024/11/18 13:33 [entrez] PHST- 2024/11/18 00:00 [pmc-release] AID - PONE-D-23-28741 [pii] AID - 10.1371/journal.pone.0313071 [doi] PST - epublish SO - PLoS One. 2024 Nov 18;19(11):e0313071. doi: 10.1371/journal.pone.0313071. eCollection 2024. PMID- 39551100 OWN - NLM STAT- MEDLINE DCOM- 20241209 LR - 20260531 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 205 DP - 2025 Jan 1 TI - "Flavor, fun, and vitamins"? Consumers' lay beliefs about child-oriented food products. PG - 107773 LID - S0195-6663(24)00577-4 [pii] LID - 10.1016/j.appet.2024.107773 [doi] AB - Health experts and consumer protection agencies have been expressing concerns about the nutritional quality and marketing of child-oriented food products for years, and political debates on child-targeted food marketing are currently happening around the world. At the same time, systematic research on laypeople's views on the topic is still scarce. However, knowing what these consumers think is highly important, as lay beliefs can affect food decision-making and consumption. We address this gap with two online studies. In Study 1 (N = 444 parents and non-parents), we develop an instrument measuring lay beliefs about child-oriented food products consisting of three scales: Nutrition-Related Concerns, Convenience, and Healthiness. We find small effects of socio-demographic factors on beliefs and observe meaningful relationships between beliefs and (i) thinking style and (ii) food purchase motives (e.g., visual appeal and convenience). In Study 2 (N = 571 parents), we validate the factor structure of the instrument by means of CFA and find that lay beliefs about Healthiness and Convenience predict self-reported purchase of child-oriented food products. With our research, we extend current knowledge on laypeople's perceptions of child-oriented food products and provide an instrument with good psychometric properties that can be applied in future studies. Our research offers valuable insights for policymakers and producers who wish to meet the actual demands of consumers. CI - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Bruckdorfer, Raphaela E AU - Bruckdorfer RE AD - Economic and Consumer Psychology, Faculty of Computer Science, University of Duisburg-Essen, Lotharstr. 65, D-47057, Duisburg, Germany. Electronic address: raphaela.bruckdorfer@uni-due.de. FAU - Buttner, Oliver B AU - Buttner OB AD - Economic and Consumer Psychology, Faculty of Computer Science, University of Duisburg-Essen, Lotharstr. 65, D-47057, Duisburg, Germany. Electronic address: oliver.buettner@uni-due.de. FAU - Mau, Gunnar AU - Mau G AD - Marketing and Retailing, University of Applied Sciences Magdeburg-Stendal, Osterburger Str. 25, D-39576, Stendal, Germany. Electronic address: mau@kundenlauf.de. LA - eng PT - Journal Article DEP - 20241117 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - *Consumer Behavior MH - Child MH - *Health Knowledge, Attitudes, Practice MH - *Food Preferences/psychology MH - *Parents/psychology MH - Middle Aged MH - Nutritive Value MH - Surveys and Questionnaires MH - Young Adult MH - Adolescent MH - Taste MH - Choice Behavior OTO - NOTNLM OT - Child nutrition OT - Child-oriented food products OT - Child-targeted food marketing OT - Lay beliefs COIS- Declaration of competing interest None to declare. EDAT- 2024/11/18 00:31 MHDA- 2024/12/10 00:22 CRDT- 2024/11/17 19:24 PHST- 2023/11/17 00:00 [received] PHST- 2024/06/11 00:00 [revised] PHST- 2024/11/13 00:00 [accepted] PHST- 2024/12/10 00:22 [medline] PHST- 2024/11/18 00:31 [pubmed] PHST- 2024/11/17 19:24 [entrez] AID - S0195-6663(24)00577-4 [pii] AID - 10.1016/j.appet.2024.107773 [doi] PST - ppublish SO - Appetite. 2025 Jan 1;205:107773. doi: 10.1016/j.appet.2024.107773. Epub 2024 Nov 17. PMID- 39550839 OWN - NLM STAT- MEDLINE DCOM- 20241212 LR - 20250728 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 130 DP - 2025 Feb TI - Nutritional risk assessment using the Nutritional Prognostic Index predicts mortality in Advanced Chronic Liver Disease patients. PG - 112612 LID - S0899-9007(24)00261-2 [pii] LID - 10.1016/j.nut.2024.112612 [doi] AB - OBJECTIVES: Early clinical prognosis and mortality reduction remains a challenge in chronic liver disease (CLD). The full potential of the Nutritional Prognostic Index (NPI) for nutritional assessment and management in CLD patients remains unexplored. The aim of this study was to establish an NPI cutoff point for the identification of nutritional risk in advanced CLD (ACLD) patients, as well as to assess the NPI's ability to predict ACLD-associated mortality. METHODS: This ethically approved prospective cohort study investigated malnutrition risk using both the NPI and the Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT) in patients hospitalized for ACLD. NPI reference values were determined using a receiver operating characteristic curve. Associations between nutritional risk identified by the RFH-NPT and the NPI were assessed using Fisher's exact test, and agreement between tools was assessed using the Kappa index. The association between NPI-defined nutritional risk and 12-mo mortality was examined using Pearson Chi-square test. RESULTS: The sample population consisted of 120 adults, comprising 84 (70%) male and 57 (50.9%) of alcoholic etiology and presenting as Child-Pugh A, B, or C at admission. The identified cutoff point for NPI was <41, identifying nutritional risk in 82.5% of patients. The NPI presented a statistically significant association with the RFH-NPT, with a substantial agreement coefficient of 0.34. An association between NPI <41 cutoff and mortality were observed, with 82.1% of the sample below cutoff experiencing mortality within 12 mo. CONCLUSIONS: The NPI is a valuable nutritional marker for the identification of nutritional risk in ACLD and is a simple and effective assessment tool that can aid in early CLD prognosis assessment. Validation, however, remains necessary in other CLD populations of different etiologies. CI - Copyright (c) 2024 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Santos, Ketsia Meneses Souza AU - Santos KMS AD - Food, Nutrition and Health Post-Graduation Program, Federal University of Bahia, Salvador, Bahia, Brazil. FAU - Boulhosa, Ramona Souza da Silva Baqueiro AU - Boulhosa RSDSB AD - Department of Health, Salvador City Council, Brazil. FAU - Garcez, Lais Spindola AU - Garcez LS AD - Bahia Estate University, Salvador, Brazil. FAU - Lyra, Andre Castro AU - Lyra AC AD - Division of Gastroenterology & Hepatology, Department of Medicine, School of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil. FAU - Bueno, Allain Amador AU - Bueno AA AD - College of Health, Life and Environmental Science, University of Worcester, Henwick Grove, Worcester, UK. Electronic address: a.bueno@worc.ac.uk. FAU - de Jesus, Rosangela Passos AU - de Jesus RP AD - Department of Nutrition Sciences, School of Nutrition, Federal University of Bahia, Salvador, Bahia, Brazil. FAU - Oliveira, Lucivalda Pereira Magalhaes AU - Oliveira LPM AD - Department of Nutrition Sciences, School of Nutrition, Federal University of Bahia, Salvador, Bahia, Brazil. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241024 PL - United States TA - Nutrition JT - Nutrition (Burbank, Los Angeles County, Calif.) JID - 8802712 SB - IM MH - Humans MH - Male MH - *Nutrition Assessment MH - Female MH - Prognosis MH - Prospective Studies MH - Middle Aged MH - Risk Assessment/methods MH - *Malnutrition/diagnosis/mortality MH - *Nutritional Status MH - Aged MH - Adult MH - Liver Diseases/mortality MH - Chronic Disease MH - ROC Curve MH - Risk Factors OTO - NOTNLM OT - Advanced chronic liver disease OT - Nutritional Prognostic Index OT - Nutritional assessment OT - Nutritional risk OT - Nutritional screening COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/11/18 04:18 MHDA- 2024/12/13 00:23 CRDT- 2024/11/17 18:03 PHST- 2024/04/07 00:00 [received] PHST- 2024/09/08 00:00 [revised] PHST- 2024/10/18 00:00 [accepted] PHST- 2024/12/13 00:23 [medline] PHST- 2024/11/18 04:18 [pubmed] PHST- 2024/11/17 18:03 [entrez] AID - S0899-9007(24)00261-2 [pii] AID - 10.1016/j.nut.2024.112612 [doi] PST - ppublish SO - Nutrition. 2025 Feb;130:112612. doi: 10.1016/j.nut.2024.112612. Epub 2024 Oct 24. PMID- 39546495 OWN - NLM STAT- MEDLINE DCOM- 20241115 LR - 20260924 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 11 DP - 2024 TI - Virtual dentistry strategy to enhance knowledge, attitudes, and practices in selecting sweetened ultra-processed foods. PG - e0312288 LID - 10.1371/journal.pone.0312288 [doi] LID - e0312288 AB - Education on the selection of low-sugar ultra-processed foods (UPF) plays a crucial role in promoting good oral health. This study aimed to assess the impact of a virtual educational strategy, developed in the field of dentistry, on improve Knowledge, Attitudes, and Practices (KAPs) related to oral health and the appropriate selection of sweet-tasting UPF. A quasi-experimental study with a pre-test and post-test design was conducted, involving parents and caregivers of children and pre-adolescents. Thirteen virtual learning objects (VLO) were delivered via Facebook. To measure the impact of the strategy, a validated instrument was used before the intervention, immediately after, and again six months later to assess Knowledge, Attitudes, and Practices (KAPs) on the subject. The median scores before and after the intervention were compared using the Friedman test for related samples, followed by multiple comparisons with Dunn's test. Participants' KAP levels were analyzed using Pearson's Chi-square test and multiple comparisons of column proportions with Bonferroni correction. Finally, a satisfaction and applicability survey was conducted. A significant improvement (p < 0.01) was observed in the participants' median KAP scores both immediately after the intervention and six months later. A greater number of participants reached the highest level in knowledge (Before (B): 43.8%, Immediately After (IA): 86%, After six months (A6): 81.3%), attitudes (B: 34.2%, IA: 69.4%, A6: 65.2%), and practices (B: 22.5%, IA: 53.7%, A6: 47.3%). Most participants described the course as consistently dynamic, well-organized, and appropriate timing. They also expressed their intention to apply the knowledge in their daily lives. The implemented strategy improved participants' KAPs concerning oral health and the appropriate selection of sweet-tasting UPF. It also resulted in participants' children consuming fewer sweet bakery products, candies, and flavored milk. Additionally, more participants reported consistently reading food labels after the intervention, although this behavior was not adopted by the majority. CI - Copyright: (c) 2024 Angarita-Diaz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Angarita-Diaz, Maria Del Pilar AU - Angarita-Diaz MDP AUID- ORCID: 0000-0002-5435-3456 AD - Facultad de Odontologia, Universidad Cooperativa de Colombia, Villavicencio, Colombia. FAU - Colmenares-Pedraza, Johao Alexander AU - Colmenares-Pedraza JA AD - Food Security and Nutrition Dimension, Public Health Department, Villavicencio Health Secretariat, Villavicencio, Colombia. FAU - Arias-Ramirez, Johanna Carolina AU - Arias-Ramirez JC AD - Facultad de Odontologia, Universidad Cooperativa de Colombia, Villavicencio, Colombia. FAU - Cabrera-Arango, Claudia Liliana AU - Cabrera-Arango CL AD - Facultad de Odontologia, Universidad Cooperativa de Colombia, Villavicencio, Colombia. FAU - Cisneros-Hidalgo, Cristhian Ariel AU - Cisneros-Hidalgo CA AD - Facultad de Odontologia, Universidad Cooperativa de Colombia, Villavicencio, Colombia. FAU - Munoz-Espitia, Sharon Daniela AU - Munoz-Espitia SD AD - Facultad de Odontologia, Universidad Cooperativa de Colombia, Villavicencio, Colombia. FAU - Garzon-Baquero, Jeisson Armando AU - Garzon-Baquero JA AD - Facultad de Odontologia, Universidad Cooperativa de Colombia, Villavicencio, Colombia. LA - eng GR - INV-003305/Bill & Melinda Gates Foundation/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241115 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Sweetening Agents) SB - IM MH - Humans MH - Female MH - *Health Knowledge, Attitudes, Practice MH - Male MH - Child MH - Adult MH - Fast Foods MH - Dentistry MH - Oral Health MH - Sweetening Agents MH - Adolescent MH - Food Preferences/psychology MH - Food, Processed PMC - PMC11567513 COIS- The authors have declared that no competing interests exist. EDAT- 2024/11/15 18:23 MHDA- 2024/11/16 10:00 PMCR- 2024/11/15 CRDT- 2024/11/15 13:43 PHST- 2024/03/14 00:00 [received] PHST- 2024/10/03 00:00 [accepted] PHST- 2024/11/16 10:00 [medline] PHST- 2024/11/15 18:23 [pubmed] PHST- 2024/11/15 13:43 [entrez] PHST- 2024/11/15 00:00 [pmc-release] AID - PONE-D-24-09872 [pii] AID - 10.1371/journal.pone.0312288 [doi] PST - epublish SO - PLoS One. 2024 Nov 15;19(11):e0312288. doi: 10.1371/journal.pone.0312288. eCollection 2024. PMID- 39545934 OWN - NLM STAT- MEDLINE DCOM- 20251208 LR - 20260916 IS - 1940-3208 (Electronic) IS - 0744-8481 (Linking) VI - 73 IP - 9 DP - 2025 Nov TI - Encouraging movement opportunities through theory-informed video education among undergraduate students: the MOVE study. PG - 3549-3564 LID - 10.1080/07448481.2024.2427055 [doi] AB - Objective: To explore the impact of a theory-informed educational video on undergraduates': motivational readiness, self-efficacy, and decisional balance about changing sedentary time; sedentary time; and perceptions of sedentarism over time and compared to a control. Participants: Undergraduates (N = 160) from a Canadian institution. Methods: A single-blind randomized controlled trial using an intervention (sedentary video) and control (sleep video) group. Participants completed two validated questionnaires at baseline, immediate post-intervention, and one-month follow-up plus open-ended questions. Linear mixed models and content analysis were used. Results: No significant differences were observed between groups. Increases in self-efficacy (p = .016; d = 0.27) and decisional balance (p = .008; d = 0.31) were observed within intervention participants from baseline to post-intervention, and decreases in sedentary time at post-intervention (p = .032; d = -0.40) and follow-up (p = .006; d = -0.46). Conclusions: This theory-informed sedentary time video shows promise regarding undergraduates' sedentarism. FAU - Labadie, Carmen T AU - Labadie CT AUID- ORCID: 0000-0002-8489-8078 AD - Health and Rehabilitation Sciences Program, Faculty of Health Sciences, The University of Western Ontario, London, Ontario, Canada. FAU - Contini, Nia AU - Contini N AUID- ORCID: 0000-0001-8481-7496 AD - Health and Rehabilitation Sciences Program, Faculty of Health Sciences, The University of Western Ontario, London, Ontario, Canada. FAU - Vasudevan, Varsha AU - Vasudevan V AUID- ORCID: 0000-0002-7243-1155 AD - Health and Rehabilitation Sciences Program, Faculty of Health Sciences, The University of Western Ontario, London, Ontario, Canada. FAU - Bourke, Matthew AU - Bourke M AUID- ORCID: 0000-0001-7088-4516 AD - School of Occupational Therapy, Faculty of Health Sciences, University of Western Ontario, London, Ontario, Canada. FAU - Burke, Shauna M AU - Burke SM AUID- ORCID: 0000-0003-2749-1631 AD - Health and Rehabilitation Sciences Program, Faculty of Health Sciences, The University of Western Ontario, London, Ontario, Canada. AD - School of Health Studies, Faculty of Health Sciences, The University of Western Ontario, London, Ontario, Canada. AD - Children's Health Research Institute, Lawson Health Research Institute, London, Ontario, Canada. FAU - Tucker, Patricia AU - Tucker P AUID- ORCID: 0000-0002-8392-9418 AD - Health and Rehabilitation Sciences Program, Faculty of Health Sciences, The University of Western Ontario, London, Ontario, Canada. AD - School of Occupational Therapy, Faculty of Health Sciences, University of Western Ontario, London, Ontario, Canada. AD - Children's Health Research Institute, Lawson Health Research Institute, London, Ontario, Canada. FAU - Irwin, Jennifer D AU - Irwin JD AUID- ORCID: 0000-0003-0219-4075 AD - Health and Rehabilitation Sciences Program, Faculty of Health Sciences, The University of Western Ontario, London, Ontario, Canada. AD - School of Health Studies, Faculty of Health Sciences, The University of Western Ontario, London, Ontario, Canada. LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20241115 PL - United States TA - J Am Coll Health JT - Journal of American college health : J of ACH JID - 8214119 SB - IM MH - Humans MH - Male MH - Female MH - *Students/psychology/statistics & numerical data MH - Young Adult MH - Universities/organization & administration MH - Surveys and Questionnaires MH - Single-Blind Method MH - *Sedentary Behavior MH - Self Efficacy MH - Adult MH - Canada MH - Motivation MH - *Health Promotion/methods MH - *Video Recording MH - Adolescent OTO - NOTNLM OT - Sedentary behavior OT - health belief model OT - transtheoretical model OT - university students OT - video education EDAT- 2024/11/15 17:10 MHDA- 2025/12/09 00:32 CRDT- 2024/11/15 11:03 PHST- 2025/12/09 00:32 [medline] PHST- 2024/11/15 17:10 [pubmed] PHST- 2024/11/15 11:03 [entrez] AID - 10.1080/07448481.2024.2427055 [doi] PST - ppublish SO - J Am Coll Health. 2025 Nov;73(9):3549-3564. doi: 10.1080/07448481.2024.2427055. Epub 2024 Nov 15. PMID- 39544784 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241116 IS - 1943-8141 (Print) IS - 1943-8141 (Electronic) IS - 1943-8141 (Linking) VI - 16 IP - 10 DP - 2024 TI - Analysis and prediction of protein-energy malnutrition in children aged 8-10 years. PG - 5564-5574 LID - 10.62347/QIFY1619 [doi] AB - OBJECTIVE: To identify independent risk factors for protein-energy malnutrition (PEM) in children aged 8-10 years and to develop and validate a nomogram model for estimating PEM risk. METHODS: In this retrospective study, a cohort of 1,412 children from The Fifth Affiliated Hospital of Guangzhou Medical University, spanning January 2022 to December 2023, was identified. Participants were randomly classified into a training set (n=988) and a validation set (n=424). Patients in the training set were divided into normal (n=667) and PEM (n=321) groups. Data collection involved demographic, sociological, physical, and biochemical assessments. Independent risk factors for PEM were identified using univariate and multivariate logistic regression. A nomogram risk model was constructed from significant predictors, and its performance was assessed using the receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA). An independent dataset further validated the nomogram model. RESULTS: Among the 1,412 children, 497 (35.2%) had PEM, which included stunting (11.83%), underweight (11.61%), and wasting (11.76%). Multivariate analysis identified six independent risk factors for PEM: gestational age (OR (95% CI)=5.830 (3.604-9.431), P<0.001), household income (OR (95% CI)=0.383 (0.281-0.523), P<0.001), sleep duration (OR (95% CI)=1.800 (1.319-2.457), P<0.001), mood disorders (OR (95% CI)=6.924 (4.437-10.805), P<0.001), and physical activity time (OR (95% CI)=3.210 (2.342-4.400), P<0.001). The nomogram model demonstrated good predictive performance (AUC=0.803 (0.773-0.832)) and was validated well on an independent dataset (AUC=0.783 (0.739-0.828)). CONCLUSION: The study identified key independent risk factors for PEM in children and established a robust nomogram model for clinical risk assessment. The model's high predictive accuracy and clinical applicability suggest it may be a valuable tool for the early identification and intervention strategies for PEM in clinical practice. CI - AJTR Copyright (c) 2024. FAU - Deng, Yunyan AU - Deng Y AD - Department of Pediatrics, The Fifth Affiliated Hospital of Guangzhou Medical University Guangzhou 510700, Guangdong, The People's Republic of China. FAU - Ye, Yanmei AU - Ye Y AD - Department of Obstetrics, The Fifth Affiliated Hospital of Guangzhou Medical University Guangzhou 510700, Guangdong, The People's Republic of China. FAU - Chen, Sisi AU - Chen S AD - Department of Pediatrics, The Fifth Affiliated Hospital of Guangzhou Medical University Guangzhou 510700, Guangdong, The People's Republic of China. FAU - Liang, Yawen AU - Liang Y AD - Department of Pediatrics, The Fifth Affiliated Hospital of Guangzhou Medical University Guangzhou 510700, Guangdong, The People's Republic of China. FAU - Chen, Xiaoyan AU - Chen X AD - Department of General Surgery, The Fifth Affiliated Hospital of Guangzhou Medical University Guangzhou 510700, Guangdong, The People's Republic of China. LA - eng PT - Journal Article DEP - 20241015 PL - United States TA - Am J Transl Res JT - American journal of translational research JID - 101493030 PMC - PMC11558431 OTO - NOTNLM OT - Protein-energy malnutrition OT - children OT - predictive nomogram model COIS- None. EDAT- 2024/11/15 11:00 MHDA- 2024/11/15 11:01 PMCR- 2024/10/15 CRDT- 2024/11/15 04:33 PHST- 2024/05/09 00:00 [received] PHST- 2024/07/15 00:00 [accepted] PHST- 2024/11/15 11:01 [medline] PHST- 2024/11/15 11:00 [pubmed] PHST- 2024/11/15 04:33 [entrez] PHST- 2024/10/15 00:00 [pmc-release] AID - 10.62347/QIFY1619 [doi] PST - epublish SO - Am J Transl Res. 2024 Oct 15;16(10):5564-5574. doi: 10.62347/QIFY1619. eCollection 2024. PMID- 39544543 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241116 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 16 IP - 10 DP - 2024 Oct TI - The Impact of Family Relationship on Serum 25-Hydroxyvitamin D (25OHD) Concentrations in Individuals Residing in Pune, India. PG - e71513 LID - 10.7759/cureus.71513 [doi] LID - e71513 AB - INTRODUCTION: An understanding of the influence of family relationship on vitamin D concentrations could be useful in designing community-based strategies to improve vitamin D status. Hence, the aim of this study was to explore if family relationship had an impact on total serum 25-hydroxyvitamin D (25OHD) concentrations of individuals living in Pune, India. METHODS: This cross-sectional study included 104 families. Data collected included anthropometry (height and weight), body composition (bioelectric impedance), sunlight exposure (validated questionnaire), and blood samples for estimation of serum 25OHD(2) and 25OHD(3) by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. Total serum 25OHD was computed as the sum of the serum 25OHD(2) and 25OHD(3) concentrations. Linear mixed model analysis was employed to assess the impact of family on serum 25OHD(2) and total 25OHD concentrations. The strength of the family-level component was assessed by calculating the intra-family correlation for each model separately for children and adults. RESULTS: More than half (63%) of the participants of the participants (235 adults, 118 children) had poor daily sunlight exposure (< 30 minutes). Around one-third, both adults and children, were found to be vitamin D deficient. Intra-family correlation was found to be higher in children than in adults for serum 25OHD(2) (0.6 vs 0.4) and total serum 25OHD (0.5 vs 0.1) concentrations. CONCLUSIONS: Our findings indicate that the likelihood of having similar vitamin D concentrations is higher among children as compared to adults in a family. This suggests a role played by genetic factors or possibly shared habits among children in a family, thus resulting in stronger correlations. This can facilitate the adoption of early preventive measures for treatment or prevention of vitamin D deficiency, even if one child among siblings is vitamin D insufficient. CI - Copyright (c) 2024, Mandlik et al. FAU - Mandlik, Rubina AU - Mandlik R AD - Growth and Pediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Pune, IND. FAU - Deshpande, Swapna AU - Deshpande S AD - Health Sciences, Tampere University, Tampere, FIN. AD - Growth and Pediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Pune, IND. FAU - Khadilkar, Anuradha AU - Khadilkar A AD - Growth and Pediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Pune, IND. AD - Health Sciences, Savitribai Phule Pune University, Pune, IND. LA - eng PT - Journal Article DEP - 20241015 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC11561856 OTO - NOTNLM OT - 25ohd OT - 25ohd2 OT - adults OT - children OT - family OT - intra-family correlation OT - siblings OT - vitamin d COIS- Human subjects: Consent was obtained or waived by all participants in this study. Ethics Committee Biomedical and Health Research Ethics Committee, Jehangir Clinical Development Centre Pvt. Ltd. issued approval NA. The Ethics Committee Jehangir Clinical Development Centre Pvt. Ltd. provided ethics approval for the study on July 7, 2020. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: This study was supported by the Tata Trusts (TEDT/MUM/NUT/HCJMRI/2021- 2022/0152-MA/al dt. 27 December 2021). The funders had no involvement in the study procedures or restrictions regarding publication. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2024/11/15 11:00 MHDA- 2024/11/15 11:01 PMCR- 2024/10/15 CRDT- 2024/11/15 04:30 PHST- 2024/10/10 00:00 [accepted] PHST- 2024/11/15 11:01 [medline] PHST- 2024/11/15 11:00 [pubmed] PHST- 2024/11/15 04:30 [entrez] PHST- 2024/10/15 00:00 [pmc-release] AID - 10.7759/cureus.71513 [doi] PST - epublish SO - Cureus. 2024 Oct 15;16(10):e71513. doi: 10.7759/cureus.71513. eCollection 2024 Oct. PMID- 39543853 OWN - NLM STAT- Publisher LR - 20260518 IS - 1531-8249 (Electronic) IS - 0364-5134 (Print) IS - 0364-5134 (Linking) VI - 97 IP - 1 DP - 2024 Nov 14 TI - Automated and Interpretable Detection of Hippocampal Sclerosis in Temporal Lobe Epilepsy: AID-HS. PG - 62-75 LID - 10.1002/ana.27089 [doi] AB - OBJECTIVE: Hippocampal sclerosis (HS), the most common pathology associated with temporal lobe epilepsy (TLE), is not always visible on magnetic resonance imaging (MRI), causing surgical delays and reduced postsurgical seizure-freedom. We developed an open-source software to characterize and localize HS to aid the presurgical evaluation of children and adults with suspected TLE. METHODS: We included a multicenter cohort of 365 participants (154 HS; 90 disease controls; 121 healthy controls). HippUnfold was used to extract morphological surface-based features and volumes of the hippocampus from T1-weighted MRI scans. We characterized pathological hippocampi in patients by comparing them to normative growth charts and analyzing within-subject feature asymmetries. Feature asymmetry scores were used to train a logistic regression classifier to detect and lateralize HS. The classifier was validated on an independent multicenter cohort of 275 patients with HS and 161 healthy and disease controls. RESULTS: HS was characterized by decreased volume, thickness, and gyrification alongside increased mean and intrinsic curvature. The classifier detected 90.1% of unilateral HS patients and lateralized lesions in 97.4%. In patients with MRI-negative histopathologically-confirmed HS, the classifier detected 79.2% (19/24) and lateralized 91.7% (22/24). The model achieved similar performances on the independent cohort, demonstrating its ability to generalize to new data. Individual patient reports contextualize a patient's hippocampal features in relation to normative growth trajectories, visualise feature asymmetries, and report classifier predictions. INTERPRETATION: Automated and Interpretable Detection of Hippocampal Sclerosis (AID-HS) is an open-source pipeline for detecting and lateralizing HS and outputting clinically-relevant reports. ANN NEUROL 2024. CI - (c) 2024 The Author(s). Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. FAU - Ripart, Mathilde AU - Ripart M AUID- ORCID: 0000-0002-1761-5859 AD - UCL Great Ormond Street Institute of Child Health, London, UK. FAU - DeKraker, Jordan AU - DeKraker J AD - McGill University, Montreal, Canada. FAU - Eriksson, Maria H AU - Eriksson MH AUID- ORCID: 0000-0001-6869-5804 AD - UCL Great Ormond Street Institute of Child Health, London, UK. AD - The Hospital for Sick Children (SickKids), Toronto, Canada. FAU - Piper, Rory J AU - Piper RJ AUID- ORCID: 0000-0002-6422-5853 AD - UCL Great Ormond Street Institute of Child Health, London, UK. AD - Department of Neurosurgery, Great Ormond Street Hospital, London, UK. FAU - Gopinath, Siby AU - Gopinath S AD - Amrita Advanced Centre for Epilepsy (AACE), Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India. FAU - Parasuram, Harilal AU - Parasuram H AD - Amrita Advanced Centre for Epilepsy (AACE), Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India. FAU - Mo, Jiajie AU - Mo J AUID- ORCID: 0000-0002-9721-1378 AD - Beijing Tiantan Hospital, Beijing, China. FAU - Likeman, Marcus AU - Likeman M AD - Bristol Royal Hospital for Children, Bristol, UK. FAU - Ciobotaru, Georgian AU - Ciobotaru G AD - Central Emergency Military Hospital, Bucarest, Romania. FAU - Sequeiros-Peggs, Philip AU - Sequeiros-Peggs P AD - University Hospital of Wales, Cardiff, UK. FAU - Hamandi, Khalid AU - Hamandi K AD - University Hospital of Wales, Cardiff, UK. FAU - Xie, Hua AU - Xie H AD - Center for Neuroscience, Children's National Hospital, US. FAU - Cohen, Nathan T AU - Cohen NT AUID- ORCID: 0000-0002-1410-3487 AD - Center for Neuroscience, Children's National Hospital, US. FAU - Su, Ting-Yu AU - Su TY AD - Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA. AD - Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA. FAU - Kochi, Ryuzaburo AU - Kochi R AD - Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA. FAU - Wang, Irene AU - Wang I AUID- ORCID: 0000-0002-3829-5217 AD - Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA. FAU - Rojas-Costa, Gonzalo M AU - Rojas-Costa GM AUID- ORCID: 0000-0002-6228-2678 AD - Advanced Epilepsy Center, Clinica las Condes, Santiago, Chile. AD - School of Medicine, Finis Terrae University, Santiago, Chile. FAU - Galvez, Marcelo AU - Galvez M AD - Advanced Epilepsy Center, Clinica las Condes, Santiago, Chile. AD - School of Medicine, Finis Terrae University, Santiago, Chile. FAU - Parodi, Costanza AU - Parodi C AD - Department of Neuroradiology, IRCCS Istituto Giannina Gaslini, Member of the ERN EpiCARE, Genoa, Italy. FAU - Riva, Antonella AU - Riva A AUID- ORCID: 0000-0001-9152-5571 AD - IRCCS Istituto Giannina Gaslini, Member of the ERN EpiCARE, Genoa, Italy. AD - Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genoa, Italy. FAU - D'Arco, Felice AU - D'Arco F AD - Radiology Department, Great Ormond Street Hospital for Children, London, UK. FAU - Mankad, Kshitij AU - Mankad K AD - Radiology Department, Great Ormond Street Hospital for Children, London, UK. FAU - Clark, Chris A AU - Clark CA AD - UCL Great Ormond Street Institute of Child Health, London, UK. FAU - Carbo, Adrian Valls AU - Carbo AV AUID- ORCID: 0000-0002-4831-1276 AD - Department of Neurology, Epilepsy Program, Ruber International Hospital, Madrid, Spain. FAU - Toledano, Rafael AU - Toledano R AD - Department of Neurology, Epilepsy Program, Ruber International Hospital, Madrid, Spain. FAU - Taylor, Peter AU - Taylor P AUID- ORCID: 0000-0003-2144-9838 AD - School of Computing, Newcastle University, Newcastle upon Tyne, UK. FAU - Napolitano, Antonio AU - Napolitano A AUID- ORCID: 0000-0003-3258-6846 AD - Medical Physics Unit, Bambino Gesu children's hospital, IRCCS, Member of the ERN EpiCARE, Rome, Italy. FAU - Rossi-Espagnet, Maria Camilla AU - Rossi-Espagnet MC AD - Functional and Interventional Neuroradiology Unit, Bambino Gesu children's hospital, IRCCS, Member of the ERN EpiCARE, Rome, Italy. FAU - Willard, Anna AU - Willard A AD - Department of Neuroscience, The School of Translational Medicine, Monash University, Melbourne, Australia. FAU - Sinclair, Benjamin AU - Sinclair B AUID- ORCID: 0000-0002-0850-3644 AD - Department of Neuroscience, The School of Translational Medicine, Monash University, Melbourne, Australia. AD - Department of Neurology, Alfred Health, Melbourne, Australia. FAU - Pepper, Joshua AU - Pepper J AD - Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK. FAU - Seri, Stefano AU - Seri S AD - Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK. AD - College of Health and Life Sciences, Aston University, Birmingham, UK. FAU - Devinsky, Orrin AU - Devinsky O AD - Department of Neurology, New York University Grossman School of Medicine, New York, New York, USA. FAU - Pardoe, Heath R AU - Pardoe HR AD - Department of Neurology, New York University Grossman School of Medicine, New York, New York, USA. AD - Florey Institute of Neuroscience and Mental Health, Melbourne, Australia. FAU - Winston, Gavin P AU - Winston GP AD - UCL Queen Square Institute of Neurology, London, UK. AD - Department of Medicine, Division of Neurology, Queen's University, Kingston, Canada. FAU - Duncan, John S AU - Duncan JS AD - UCL Queen Square Institute of Neurology, London, UK. AD - National Hospital for Neurology and Neurosurgery, London, UK. FAU - Yasuda, Clarissa L AU - Yasuda CL AD - Department of Neurology, UNICAMP University of Campinas, Campinas, Brazil. AD - Brazilian Institute of Neuroscience and Neurotechnology, Brazil. FAU - Scardua-Silva, Lucas AU - Scardua-Silva L AUID- ORCID: 0000-0002-0645-8456 AD - Department of Neurology, UNICAMP University of Campinas, Campinas, Brazil. FAU - Walger, Lennart AU - Walger L AD - Department of Neuroradiology, University Hospital Bonn, Bonn, Germany. AD - Department of Epileptology, University Hospital Bonn, Bonn, Germany. FAU - Ruber, Theodor AU - Ruber T AUID- ORCID: 0000-0002-6180-7671 AD - Department of Neuroradiology, University Hospital Bonn, Bonn, Germany. AD - Department of Epileptology, University Hospital Bonn, Bonn, Germany. FAU - Khan, Ali R AU - Khan AR AD - Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Canada. FAU - Baldeweg, Torsten AU - Baldeweg T AD - UCL Great Ormond Street Institute of Child Health, London, UK. FAU - Adler, Sophie AU - Adler S AUID- ORCID: 0000-0002-3978-7424 AD - UCL Great Ormond Street Institute of Child Health, London, UK. FAU - Wagstyl, Konrad AU - Wagstyl K AUID- ORCID: 0000-0003-3439-5808 AD - UCL Great Ormond Street Institute of Child Health, London, UK. AD - School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK. CN - MELD HS study group LA - eng GR - R01 NS109439/NH/NIH HHS/United States GR - VS0221/Great Ormond Street Hospital Children's Charity/ GR - Amrita Institute of Medical Sciences/ GR - PE0000006/Ministero dell'Universita e della Ricerca (MUR)/ GR - NSERC-PDF/Natural Sciences and Engineering Research Council of Canada/ GR - 1210176/Fondo Nacional de Desarrollo Cientifico y Tecnologico/ GR - Sigrid Juseliuksen Saatio/ GR - G0802012/MRC_/Medical Research Council/United Kingdom GR - NIHR Great Ormond Street Hospital Biomedical Research Centre/ GR - R21 NS117990/NS/NINDS NIH HHS/United States GR - R01 NS109439/NS/NINDS NIH HHS/United States GR - A2665/Rosetrees Trust/ GR - HCRW/HCRW_/United Kingdom GR - RGPIN-2023-05558/Natural Sciences and Engineering Research Council of Canada/ GR - 301991/Z/23/Z/WT_/Wellcome Trust/United Kingdom GR - P2208/Epilepsy Research UK/ GR - 1210195/Fondo Nacional de Desarrollo Cientifico y Tecnologico/ GR - Fundacion Iniciativa Para las Neurociencias/ GR - 366062/CIHR/ GR - Hess Foundation/ GR - R21 NS117990/NH/NIH HHS/United States GR - 1220995/Fondo Nacional de Desarrollo Cientifico y Tecnologico/ GR - WT_/Wellcome Trust/United Kingdom GR - MR/M00841X/1/MRC_/Medical Research Council/United Kingdom GR - 950-231964/Canada Research Chairs/ PT - Journal Article DEP - 20241114 PL - United States TA - Ann Neurol JT - Annals of neurology JID - 7707449 SB - IM PMC - PMC11683179 MID - NIHMS2026024 COIS- Nothing to report. FIR - Zhang, Kai IR - Zhang K FIR - Bari, S M Saiful IR - Bari SMS FIR - Galea, James IR - Galea J FIR - Illapani, Venkata Sita Priyanka IR - Illapani VSP FIR - Gaillard, William D IR - Gaillard WD FIR - Ibanez, Agustin IR - Ibanez A FIR - Faure, Evelyng IR - Faure E FIR - Campos, Manuel IR - Campos M FIR - Severino, Mariasavina IR - Severino M FIR - Tortora, Domenico IR - Tortora D FIR - Nobile, Giulia IR - Nobile G FIR - Consales, Alessandro IR - Consales A FIR - Chari, Aswin IR - Chari A FIR - Tisdall, Martin IR - Tisdall M FIR - Cross, J Helen IR - Cross JH FIR - Simpson, Callum M IR - Simpson CM FIR - Wang, Yujiang IR - Wang Y FIR - De Palma, Luca IR - De Palma L FIR - De Benedictis, Alessandro IR - De Benedictis A FIR - Vivash, Lucy IR - Vivash L FIR - O'Brien, Terence J IR - O'Brien TJ FIR - De Tisdi, Jane IR - De Tisdi J FIR - Alvim, Marina K M IR - Alvim MKM FIR - Cendes, Fernando IR - Cendes F EDAT- 2024/11/15 06:24 MHDA- 2024/11/15 06:24 PMCR- 2024/12/30 CRDT- 2024/11/15 01:23 PHST- 2024/09/23 00:00 [revised] PHST- 2023/12/21 00:00 [received] PHST- 2024/09/23 00:00 [accepted] PHST- 2024/11/15 06:24 [medline] PHST- 2024/11/15 06:24 [pubmed] PHST- 2024/11/15 01:23 [entrez] PHST- 2024/12/30 00:00 [pmc-release] AID - ANA27089 [pii] AID - 10.1002/ana.27089 [doi] PST - aheadofprint SO - Ann Neurol. 2024 Nov 14;97(1):62-75. doi: 10.1002/ana.27089. PMID- 39543672 OWN - NLM STAT- MEDLINE DCOM- 20241116 LR - 20241117 IS - 1477-7827 (Electronic) IS - 1477-7827 (Linking) VI - 22 IP - 1 DP - 2024 Nov 14 TI - Correlation between cardiometabolic index and female infertility: a cross-sectional analysis. PG - 145 LID - 10.1186/s12958-024-01312-9 [doi] LID - 145 AB - BACKGROUND: Obesity and adverse lipid profile leads to female infertility. The cardiometabolic index (CMI) is a promising indicator for predicting obesity-related diseases. The correlation between CMI and female infertility merits further investigation. METHODS: The data for this study were acquired from the 2013-2020 National Health and Nutrition Examination Survey (NHANES), with 2333 women enrolled. The cardiometabolic index (CMI) of each participant was calculated as the ratio of triglycerides and high-density lipoprotein cholesterol multiplied by waist-to-height ratio. Weighted multivariate logistic regression models were used to assess the independent correlation between the log-transformed CMI and infertility. Subgroup analyses were carried out to assess the reliability of the findings. Interaction tests were employed to determine whether variables affected infertility by interacting with log CMI. RESULTS: A total of 2333 participants aged 18-45 years were enrolled, 274 of whom were infertile. Log CMI of the infertility group was significantly higher than that of the non-infertility group (P < 0.001). After adjustment for potential confounders, women with higher CMI were at an increased risk of infertility (OR = 2.411, 95% CI: 1.416-4.112), and this correlation was still consistent in subgroups aged under 35 years (P < 0.001). Furthermore, restricted cubic spline analysis showed a positive non-linear relationship between log CMI and infertility. CONCLUSIONS: Cardiometabolic index levels are positively correlated with increased risk of infertility in American females. Our study demonstrates the predictive capacity of CMI for female infertility. CI - (c) 2024. The Author(s). FAU - Zhao, Yiran AU - Zhao Y AD - Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, China. AD - Shanghai Key Laboratory of Reproduction and Development, Shanghai, China. FAU - Shi, Weihui AU - Shi W AD - Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, China. AD - Shanghai Key Laboratory of Reproduction and Development, Shanghai, China. FAU - Liu, Yang AU - Liu Y AD - Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, China. AD - Shanghai Key Laboratory of Reproduction and Development, Shanghai, China. FAU - Qin, Ningxin AU - Qin N AD - Shanghai First Maternity and Infant Hospital, Shanghai, China. qinningxin@163.com. FAU - Huang, Hefeng AU - Huang H AD - Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, China. huanghefg@hotmail.com. AD - Shanghai Key Laboratory of Reproduction and Development, Shanghai, China. huanghefg@hotmail.com. AD - Research Units of Embryo Original Diseases, Chinese Academy of Medical Sciences, No. 2019RU056), Shanghai, China. huanghefg@hotmail.com. AD - Key Laboratory of Reproductive Genetics (Ministry of Education), Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China. huanghefg@hotmail.com. LA - eng GR - 82301814/National Natural Science Foundation of China/ GR - 82201882/National Natural Science Foundation of China/ GR - 82088102/National Natural Science Foundation of China/ GR - 2019-I2M-5-064/CAMS Innovation Fund for Medical Sciences/ GR - 2020CXJQ01/Collaborative Innovation Program of Shanghai Municipal Health Commission/ GR - GWVI-11.1-35/Key Discipline Construction Project (2023-2025) of Three-Year Initiative Plan for Strengthening Public Health System Construction in Shanghai/ GR - 22MC1940200/Shanghai Clinical Research Center for Gynecological Diseases/ GR - 2022ZZ01012/Shanghai Urogenital System Diseases Research Center/ PT - Journal Article DEP - 20241114 PL - England TA - Reprod Biol Endocrinol JT - Reproductive biology and endocrinology : RB&E JID - 101153627 RN - 0 (Triglycerides) RN - 0 (Cholesterol, HDL) SB - IM MH - Humans MH - Female MH - Adult MH - Cross-Sectional Studies MH - *Infertility, Female/blood/epidemiology/diagnosis MH - Young Adult MH - *Triglycerides/blood MH - Adolescent MH - Middle Aged MH - *Nutrition Surveys MH - Cholesterol, HDL/blood MH - Cardiometabolic Risk Factors MH - Cardiovascular Diseases/epidemiology/etiology/blood MH - Obesity/complications/blood/epidemiology MH - Waist-Height Ratio PMC - PMC11562622 OTO - NOTNLM OT - Cardiometabolic index OT - Female infertility OT - NHANES OT - Obesity COIS- Declarations Consent for publication Not applicable. Competing interests The authors declare no competing interests. Ethics approval and consent to participate All data obtained from NHANES were reviewed and approved by National Center for Health Statistics (NCHS) Ethics Review Board and all participants agreed on the survey and signed written consent. The NHANES was conducted in compliance with local laws and institutional guidelines. Since NHANES is a publicly accessible database, no additional ethical approvals are required. EDAT- 2024/11/15 06:25 MHDA- 2024/11/16 22:26 PMCR- 2024/11/14 CRDT- 2024/11/15 00:14 PHST- 2024/08/06 00:00 [received] PHST- 2024/11/02 00:00 [accepted] PHST- 2024/11/16 22:26 [medline] PHST- 2024/11/15 06:25 [pubmed] PHST- 2024/11/15 00:14 [entrez] PHST- 2024/11/14 00:00 [pmc-release] AID - 10.1186/s12958-024-01312-9 [pii] AID - 1312 [pii] AID - 10.1186/s12958-024-01312-9 [doi] PST - epublish SO - Reprod Biol Endocrinol. 2024 Nov 14;22(1):145. doi: 10.1186/s12958-024-01312-9. PMID- 39543547 OWN - NLM STAT- MEDLINE DCOM- 20241115 LR - 20260309 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 Nov 14 TI - Effects of blended learning in physical education on university students' exercise attitudes and basketball skills: a cluster randomized controlled trial. PG - 3170 LID - 10.1186/s12889-024-20469-x [doi] LID - 3170 AB - BACKGROUND: The importance of physical education in higher education is widely recognized, as it improves not only exercise attitudes and motor skills but also physical fitness, social skills, and academic performance. However, physical education courses in Chinese colleges and universities face various constraints, such as a shortage of teachers, limited teaching methods, and insufficient resources, resulting in low student motor skills, negative attitudes toward sports, and low participation rates. This study explores the effectiveness of a blended learning model, which integrates traditional face-to-face instruction with online learning components, in improving university students' exercise attitudes and basketball skills. METHODS: The research was conducted in 2022 at Luoyang Normal University in China, utilizing a cluster randomized controlled trial (CRCT) with 78 healthy first-year university students. Participants were randomly assigned to either the experimental group (blended learning) or the control group (traditional learning), and the intervention lasted 16 weeks. Exercise attitudes were assessed via the Exercise Attitude Scale, whereas basketball skills were evaluated via set shot and half-court dribbling and shooting tests. RESULTS: Both instructional models improved students' exercise attitudes and basketball skills; however, the blended learning model demonstrated significantly superior outcomes. Effect sizes (d) ranging from 0.57 to 1.92 indicated that the experimental group showed greater improvements in behavior attitude, target attitude, behavior cognition, behavior intention, emotional experience, behavior control, and subjective standards. In basketball skills, the experimental group outperformed the control group in set shots (d = 0.56) and half-court dribbling and shooting (d = 0.46). CONCLUSION: Compared with traditional methods, blended learning significantly enhances university students' exercise attitudes and basketball skills. Future research should explore the long-term effects and underlying mechanisms of blended learning in physical education, involving larger and more diverse samples to validate these findings. CI - (c) 2024. The Author(s). FAU - Wang, Chen AU - Wang C AD - School of Physical Education, Jiangsu Second Normal University, Nanjing, China. FAU - Yuan, Yubin AU - Yuan Y AD - Department of Sports Studies, Faculty of Educational Studies, Universiti Putra Malaysia, Selangor, Serdang, Malaysia. yuanyubinupm@qq.com. FAU - Ji, Xueyan AU - Ji X AD - Department of Sports Studies, Faculty of Educational Studies, Universiti Putra Malaysia, Selangor, Serdang, Malaysia. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20241114 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - Young Adult MH - *Basketball/psychology MH - China MH - *Exercise/psychology MH - *Physical Education and Training/methods MH - *Students/psychology/statistics & numerical data MH - *Universities MH - *Attitude to Health MH - *Motor Skills MH - Learning PMC - PMC11566481 OTO - NOTNLM OT - Basketball skills OT - Blended learning OT - Exercise attitude OT - Higher education OT - Physical education COIS- Declarations Ethical approval This study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of Universiti Putra Malaysia (Approval No. JKEUPM 2022-030). Consent for publication Not applicable. Informed consent All the students voluntarily participated in the study and provided informed consent. Competing interests The authors declare no competing interests. EDAT- 2024/11/15 06:25 MHDA- 2024/11/16 09:57 PMCR- 2024/11/14 CRDT- 2024/11/15 00:08 PHST- 2024/08/28 00:00 [received] PHST- 2024/10/21 00:00 [accepted] PHST- 2024/11/16 09:57 [medline] PHST- 2024/11/15 06:25 [pubmed] PHST- 2024/11/15 00:08 [entrez] PHST- 2024/11/14 00:00 [pmc-release] AID - 10.1186/s12889-024-20469-x [pii] AID - 20469 [pii] AID - 10.1186/s12889-024-20469-x [doi] PST - epublish SO - BMC Public Health. 2024 Nov 14;24(1):3170. doi: 10.1186/s12889-024-20469-x. PMID- 39540677 OWN - NLM STAT- MEDLINE DCOM- 20250425 LR - 20260924 IS - 2163-8306 (Electronic) IS - 2163-8306 (Linking) VI - 14 IP - 2 DP - 2025 Feb TI - Artificial intelligence modeling of biomarker-based physiological age: Impact on phase 1 drug-metabolizing enzyme phenotypes. PG - 302-316 LID - 10.1002/psp4.13273 [doi] AB - Age and aging are important predictors of health status, disease progression, drug kinetics, and effects. The purpose was to develop ensemble learning-based physiological age (PA) models for evaluating drug metabolism. National Health and Nutrition Examination Survey (NHANES) data were modeled with ensemble learning to obtain two PA models, PA-M1 and PA-M2. PA-M1 included body composition, blood and urine biomarkers, and disease variables as predictors. PA-M2 had blood and urine-derived variables as predictors. Activity phenotypes for cytochrome-P450 (CYP) CYP2E1, CYP1A2, CYP2A6, xanthine oxidase (XO), and N-acetyltransferase-2 (NAT-2) and telomere attrition were assessed. Bayesian networks were used to obtain mechanistic systems pharmacology model structures for PA. The study included n = 22,307 NHANES participants (51.5% female, mean age 46.0 years, range: 18-79 years). The PA-M1 and PA-M2 distributions had greater dispersion across age strata with a right skew for younger age strata and a left skew for older age strata. There was no evidence of algorithmic bias based on sex or race/ethnicity. Klotho, lean body mass, glycohemoglobin, and systolic blood pressure were the top four predictors for PA-M1. Glycohemoglobin, serum creatinine, total cholesterol, and urine creatinine were the top four predictors for PA-M2. The models also performed satisfactorily in independent validation. Model-predicted PA was associated with CYP2E1, CYP1A2, CYP2A6, XO, and NAT-2 activity. Telomere attrition was associated with greater PA-M1 and PA-M2. Ensemble learning models provide robust assessments of PA from easily obtained blood and urine biomarkers. PA is associated with Phase I drug-metabolizing enzyme phenotypes. CI - (c) 2024 The Author(s). CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. FAU - Bhat, Amruta Gajanan AU - Bhat AG AUID- ORCID: 0009-0001-5180-7790 AD - Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, New York, USA. FAU - Ramanathan, Murali AU - Ramanathan M AUID- ORCID: 0000-0002-9943-150X AD - Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, New York, USA. AD - Department of Neurology, University at Buffalo, The State University of New York, Buffalo, New York, USA. LA - eng PT - Journal Article DEP - 20241114 PL - United States TA - CPT Pharmacometrics Syst Pharmacol JT - CPT: pharmacometrics & systems pharmacology JID - 101580011 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Male MH - Middle Aged MH - Biomarkers/metabolism MH - Adult MH - Aged MH - Adolescent MH - Young Adult MH - *Aging/metabolism/physiology MH - Phenotype MH - *Artificial Intelligence MH - Nutrition Surveys MH - Bayes Theorem MH - *Models, Biological MH - Age Factors PMC - PMC11812938 COIS- The authors declared no competing interests for this work. EDAT- 2024/11/14 17:37 MHDA- 2025/02/11 18:21 PMCR- 2024/11/14 CRDT- 2024/11/14 08:34 PHST- 2024/09/30 00:00 [revised] PHST- 2024/09/30 00:00 [received] PHST- 2024/10/24 00:00 [accepted] PHST- 2025/02/11 18:21 [medline] PHST- 2024/11/14 17:37 [pubmed] PHST- 2024/11/14 08:34 [entrez] PHST- 2024/11/14 00:00 [pmc-release] AID - PSP413273 [pii] AID - 10.1002/psp4.13273 [doi] PST - ppublish SO - CPT Pharmacometrics Syst Pharmacol. 2025 Feb;14(2):302-316. doi: 10.1002/psp4.13273. Epub 2024 Nov 14. PMID- 39534658 OWN - NLM STAT- MEDLINE DCOM- 20241113 LR - 20260923 IS - 2046-1402 (Electronic) IS - 2046-1402 (Linking) VI - 13 DP - 2024 TI - Young Adults Journey with Digital Fitness Tools-A Qualitative Study on Use of Fitness Tracking Device. PG - 1296 LID - 10.12688/f1000research.158037.1 [doi] LID - 1296 AB - BACKGROUND: Physical activity trackers possess the potential to encourage increased physical activity. However, users often exhibit poor long-term adherence to these devices, which may stem from a lack of understanding of the factors influencing their use, as well as changes in health behavior. This study aims to provide new insights into the types of health-related apps and devices that young people discover, select, and utilize, along with the underlying reasons for their choices. METHODS: Young adults aged between 18-25 years reporting the use and nonuse of health apps and wearables were recruited and participated in focus group discussions about app choice, features, their perceptions towards the physical activity trackers, and reasons for continued use and for not using one. A total of Nine FGDS were conducted among users, nonusers, and former users of physical activity tracker usage. Data was recorded, transcribed, and analyzed for themes in an iterative approach. RESULTS: The physical activity tracker users group stated that they had a sense of achievement, validation, and other motivational feedback, which helped with adherence. All three groups (user, non-user, and former user) had similar concerns about cost, reliability, accuracy, and dependency. Former users also reported that the idea of accomplishing the goals would create anxiety and, in turn, harm the body. Former users and nonusers expressed their concerns regarding lack of time and loss of motivation to track their physical activity. Nonusers had issues with the functionality of the device (ease of use, battery, notifications, apps hang) and were also aware of all the health benefits of using wearables. CONCLUSION: Physical activity users group, former users group, and nonusers group shared concerns about accuracy, cost, and battery. CI - Copyright: (c) 2024 Gulati AK et al. FAU - Gulati, Asees Kaur AU - Gulati AK AD - Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. FAU - Lobo, Rachel Edna AU - Lobo RE AD - Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. FAU - N, Nihala AU - N N AD - Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. FAU - Bhat, Vishweshwara AU - Bhat V AD - Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. FAU - Bora, Neha AU - Bora N AUID- ORCID: 0009-0007-4348-1798 AD - Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. FAU - K, Vaishali AU - K V AUID- ORCID: 0000-0001-5746-1682 AD - Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. FAU - Sinha, Mukesh Kumar AU - Sinha MK AUID- ORCID: 0000-0002-7407-7153 AD - Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. LA - eng SI - figshare/10.6084/m9.figshare.27249390.v2 PT - Journal Article DEP - 20241029 PL - England TA - F1000Res JT - F1000Research JID - 101594320 SB - IM MH - Humans MH - Young Adult MH - Male MH - Female MH - Adult MH - Adolescent MH - *Fitness Trackers MH - *Qualitative Research MH - *Mobile Applications MH - Exercise MH - Focus Groups MH - Physical Fitness PMC - PMC11555328 OTO - NOTNLM OT - Digital tracking OT - barriers and facilitators OT - device OT - exercise OT - fitness OT - mobile health OT - physical activity OT - wearables OT - young adults COIS- No competing interests were disclosed. EDAT- 2024/11/13 13:54 MHDA- 2024/11/13 13:55 PMCR- 2024/10/29 CRDT- 2024/11/13 04:24 PHST- 2024/10/23 00:00 [accepted] PHST- 2024/11/13 13:55 [medline] PHST- 2024/11/13 13:54 [pubmed] PHST- 2024/11/13 04:24 [entrez] PHST- 2024/10/29 00:00 [pmc-release] AID - 10.12688/f1000research.158037.1 [doi] PST - epublish SO - F1000Res. 2024 Oct 29;13:1296. doi: 10.12688/f1000research.158037.1. eCollection 2024. PMID- 39529046 OWN - NLM STAT- MEDLINE DCOM- 20241112 LR - 20250708 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 Nov 11 TI - The Chinese version of the physical activity questionnaire for adolescents: a psychometric validity, reliability, and invariance study. PG - 3117 LID - 10.1186/s12889-024-20563-0 [doi] LID - 3117 AB - BACKGROUND: The Physical Activity Questionnaire for Adolescents (PAQ-A) is one of the most commonly used questionnaires for assessing adolescents' levels of moderate to vigorous physical activity (PA). Although a Chinese version of the PAQ-A (comprising nine items) exists, it has been assessed for only internal consistency coefficients, test-retest reliability, and correlations with the GT3X + accelerometer. Therefore, this study aimed to evaluate the psychometric properties of the Chinese version of the PAQ-A among Chinese adolescents. METHODS: This study included three samples of 1,101 secondary school students (12-19 years old). The first sample consisted of 518 participants (50.4% males, 49.6% females) for correlation tests and exploratory factor analysis (EFA). The second sample consisted of 227 participants (55.75% males, 44.24% females) for confirmatory factor analysis (CFA), convergent validity, and sample size invariance tests. The third sample consisted of 356 participants (54.50% male, 45.50% female) for the internal consistency reliability test, invariance test (cross sample size, education level and gender), and t-test. RESULTS: Pearson correlation analysis of the PAQ-A indicated that all the total-item correlations exceeded 0.2, indicating good consistency across the items. Subsequent EFA of the Chinese version of the PAQ-A revealed a two-factor structure. CFA subsequently validated this structure. One of the items exhibited a standardized loading below 0.4 and was excluded. The exclusion of this item resulted in increased standardized loadings for the remaining items, ranging from 0.40 to 0.82, which indicates improved fit indices. This adjustment underscores the questionnaire's satisfactory convergent validity and robust discriminant validity. The overall Cronbach's alpha was 0.821, with the values for the first and second factors being 0.757 and 0.716, respectively. The questionnaire demonstrated stable invariance across sample sizes and education levels and additionally showed partial scalar invariance across genders. A t-test revealed a significant difference between males and females, which aligns with previous findings. These findings supported the construct validity of the questionnaire. CONCLUSION: This study validated the Chinese version of the PAQ-A for assessing adolescent PA in China, with a two-factor structure improved by removing one item. CI - (c) 2024. The Author(s). FAU - Qin, Ling AU - Qin L AD - Faculty of Physical Education and Health Science, Chongqing Normal University, Chongqing, China. AD - Faculty of Sports and Exercise Science, Universiti Malaya, Kuala Lumpur, Malaysia. FAU - Ho, Walter King Yan AU - Ho WKY AD - Tokyo Gakugei University, Tokyo, Japan. FAU - Khoo, Selina AU - Khoo S AD - Faculty of Sports and Exercise Science, Universiti Malaya, Kuala Lumpur, Malaysia. selina@um.edu.my. LA - eng GR - KJQN202200502/Chongqing Municipal Education Commission in China/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20241111 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Male MH - Female MH - *Psychometrics MH - Adolescent MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - China MH - *Exercise/psychology MH - Young Adult MH - Child MH - Factor Analysis, Statistical PMC - PMC11556056 OTO - NOTNLM OT - China OT - Invariance OT - Physical activity OT - Psychometric properties OT - Questionnaire validation OT - Reliability OT - Validity OT - Youth COIS- Declarations Ethics approval and consent to participate The Universiti Malaya Ethics Committee reviewed and approved this study, reference number UM.TNC2/UMREC-2042. This study adhered to the guidelines set forth in the Declaration of Helsinki, and written informed consent was secured from the parents. Consent for publication Not applicable. Competing interests The authors declare no competing interests. EDAT- 2024/11/13 13:56 MHDA- 2024/11/13 13:57 PMCR- 2024/11/11 CRDT- 2024/11/11 23:53 PHST- 2024/04/27 00:00 [received] PHST- 2024/10/29 00:00 [accepted] PHST- 2024/11/13 13:57 [medline] PHST- 2024/11/13 13:56 [pubmed] PHST- 2024/11/11 23:53 [entrez] PHST- 2024/11/11 00:00 [pmc-release] AID - 10.1186/s12889-024-20563-0 [pii] AID - 20563 [pii] AID - 10.1186/s12889-024-20563-0 [doi] PST - epublish SO - BMC Public Health. 2024 Nov 11;24(1):3117. doi: 10.1186/s12889-024-20563-0. PMID- 39527578 OWN - NLM STAT- MEDLINE DCOM- 20241111 LR - 20260903 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 11 DP - 2024 TI - Validation and invariance testing of the English Short Physical activity enjoyment scale. PG - e0313626 LID - 10.1371/journal.pone.0313626 [doi] LID - e0313626 AB - Enjoyment is recognized as a determinant of physical activity habits. The enjoyment of engaging in physical activity can be measured with the Physical Activity Enjoyment Scale (PACES). Later versions of this scale have been shortened to capture the component of subjective feeling, which has been validated using German-speaking samples. The aim of this study was to examine internal consistency, factorial validity, criterion-related validity, test-retest reliability, and measurement invariance (across gender and languages) in an English-speaking population. Data on physical activity enjoyment and self-reported physical activity were collected through an online survey with a test-retest design (n = 276,189 female, M = 42.55, SD = 16.81 years) conducted from September 2023 to December 2023. In addition, a German-speaking sample (n = 1017, 497 female, M = 29.77, SD = 13.54 years) was analyzed to assess measurement invariance with respect to language. McDonald's omega at time 1 was omega = 0.95. The confirmatory factor analysis supports the assumption of the unidimensional structure of PACES-S (chi2 = 19.8, df = 2, p < 0.05; CFI = 0.984; RMSEA = 0.180, 90% CI [0.113-0.256]), as the model fit can be estimated as good in view of the CFI value, while the sensitivity of the chi2 test is very high and the RMSEA may underestimate the model fit. Although the RMSEA value is higher than the conventional threshold, the small number of degrees of freedom may have a significant impact on this indicator. The criterion-related validity for light physical activity was r(107) = 0.26 (p < 0.05). The retest reliability was r(199) = 0.69 (p < 0.05). Further, the results supported measurement invariance across gender and partial measurement invariance across languages. Overall, the English PACES-S demonstrated good psychometric properties specifically for light intensity of physical activity, and can serve as an economical instrument to assess physical activity enjoyment. CI - Copyright: (c) 2024 Weyland et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Weyland, Susanne AU - Weyland S AUID- ORCID: 0000-0002-1411-9016 AD - Department of Health Education and Sports Psychology, Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Kaushal, Navin AU - Kaushal N AD - Department of Health Sciences, School of Health & Human Sciences, Indiana University, Indianapolis, Indiana, United States of America. FAU - Fritsch, Julian AU - Fritsch J AD - Department of Health Education and Sports Psychology, Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. AD - Department of Sports Sciences, Sport and Exercise Psychology Unit, Goethe University Frankfurt, Frankfurt, Germany. FAU - Strauch, Ulrich AU - Strauch U AD - Department of Health Education and Sports Psychology, Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Jekauc, Darko AU - Jekauc D AUID- ORCID: 0000-0002-7640-5149 AD - Department of Health Education and Sports Psychology, Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. LA - eng PT - Journal Article PT - Validation Study DEP - 20241111 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - *Exercise/psychology MH - Male MH - Adult MH - Middle Aged MH - Surveys and Questionnaires MH - Psychometrics/methods MH - Reproducibility of Results MH - Young Adult MH - Self Report MH - Language MH - Factor Analysis, Statistical MH - Pleasure MH - Adolescent PMC - PMC11554230 COIS- The authors have declared that no competing interests exist. EDAT- 2024/11/13 13:49 MHDA- 2024/11/13 13:50 PMCR- 2024/11/11 CRDT- 2024/11/11 13:35 PHST- 2024/07/22 00:00 [received] PHST- 2024/10/29 00:00 [accepted] PHST- 2024/11/13 13:50 [medline] PHST- 2024/11/13 13:49 [pubmed] PHST- 2024/11/11 13:35 [entrez] PHST- 2024/11/11 00:00 [pmc-release] AID - PONE-D-24-25628 [pii] AID - 10.1371/journal.pone.0313626 [doi] PST - epublish SO - PLoS One. 2024 Nov 11;19(11):e0313626. doi: 10.1371/journal.pone.0313626. eCollection 2024. PMID- 39527558 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241116 IS - 2767-3170 (Electronic) IS - 2767-3170 (Linking) VI - 3 IP - 11 DP - 2024 Nov TI - How can digital citizen science approaches improve ethical smartphone use surveillance among youth: Traditional surveys versus ecological momentary assessments. PG - e0000448 LID - 10.1371/journal.pdig.0000448 [doi] LID - e0000448 AB - Ubiquitous use of smartphones among youth poses significant challenges related to non-communicable diseases, including poor mental health. Although traditional survey measures can be used to assess smartphone use among youth, they are subject to recall bias. This study aims to compare self-reported smartphone use via retrospective modified traditional recall survey and prospective Ecological Momentary Assessments (EMAs) among youth. This study uses data from the Smart Platform, which engages with youth as citizen scientists. Youth (N = 77) aged 13-21 years in two urban jurisdictions in Canada (Regina and Saskatoon) engaged with our research team using a custom-built application via their own smartphones to report on a range of behaviours and outcomes on eight consecutive days. Youth reported smartphone use utilizing a traditional validated measure, which was modified to capture retrospective smartphone use on both weekdays and weekend days. In addition, daily EMAs were also time-triggered over a period of eight days to capture prospective smartphone use. Demographic, behavioural, and contextual factors were also collected. Data analyses included t-test and linear regression using Python statistical software. There was a significant difference between weekdays, weekends and overall smartphone use reported retrospectively and prospectively (p-value = <0.001), with youth reporting less smartphone use via EMAs. Overall retrospective smartphone use was significantly associated with not having a part-time job (beta = 139.64, 95% confidence interval [CI] = 34.759, 244.519, p-value = 0.010) and having more than two friends who are physically active (beta = -114.72, 95%[CI] = -208.872, -20.569, p-value = 0.018). However, prospective smartphone use reported via EMAs was not associated with any behavioural and contextual factors. The findings of this study have implications for appropriately understanding and monitoring smartphone use in the digital age among youth. EMAs can potentially minimize recall bias of smartphone use among youth, and other behaviours such as physical activity. More importantly, digital citizen science approaches that engage large populations of youth using their own smartphones can transform how we ethically monitor and mitigate the impact of excessive smartphone use. CI - Copyright: (c) 2024 Al-akshar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Al-Akshar, Sarah AU - Al-Akshar S AD - DEPtH Lab, School of Health Studies, Faculty of Health Sciences, Western University, London, Ontario, Canada. FAU - Tolulope Ibrahim, Sheriff AU - Tolulope Ibrahim S AD - DEPtH Lab, School of Health Studies, Faculty of Health Sciences, Western University, London, Ontario, Canada. FAU - Katapally, Tarun Reddy AU - Katapally TR AUID- ORCID: 0000-0001-5765-1435 AD - DEPtH Lab, School of Health Studies, Faculty of Health Sciences, Western University, London, Ontario, Canada. AD - Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. AD - Children's Health Research Institute, Lawson Health Research Institute, 750 Base Line Road East, Suite 300, London, Ontario, Canada. LA - eng PT - Journal Article DEP - 20241111 PL - United States TA - PLOS Digit Health JT - PLOS digital health JID - 9918335064206676 PMC - PMC11554190 COIS- The authors have declared that no competing interests exist EDAT- 2024/11/13 13:47 MHDA- 2024/11/13 13:48 PMCR- 2024/11/11 CRDT- 2024/11/11 13:34 PHST- 2024/01/25 00:00 [received] PHST- 2024/09/08 00:00 [accepted] PHST- 2024/11/13 13:48 [medline] PHST- 2024/11/13 13:47 [pubmed] PHST- 2024/11/11 13:34 [entrez] PHST- 2024/11/11 00:00 [pmc-release] AID - PDIG-D-24-00015 [pii] AID - 10.1371/journal.pdig.0000448 [doi] PST - epublish SO - PLOS Digit Health. 2024 Nov 11;3(11):e0000448. doi: 10.1371/journal.pdig.0000448. eCollection 2024 Nov. PMID- 39526897 OWN - NLM STAT- MEDLINE DCOM- 20241220 LR - 20260819 IS - 1475-2662 (Electronic) IS - 0007-1145 (Linking) VI - 132 IP - 11 DP - 2024 Dec 14 TI - Comparison of BMI, triponderal mass index and paediatric body adiposity index for predicting body fat and screening obesity in preschool children. PG - 1466-1473 LID - 10.1017/S0007114524002046 [doi] AB - Several novel anthropometric indices, including paediatric body adiposity index (BAIp) and triponderal mass index (TMI), have emerged as potential tools for estimating body fat in preschool children. However, their comparative validity and accuracy, particularly when compared with established indicators such as BMI, have not been thoroughly investigated. This cross-sectional study enrolled 2869 preschoolers aged 3-6 years in Wuhan, China. The non-parametric Bland-Altman analysis was employed to evaluate the agreement between BMI, BAIp and TMI with percentage of body fat (PBF), determined by bioelectrical impedance analysis (BIA), serving as the reference measure of adiposity. Additionally, receiver operating characteristic curve analysis was conducted to assess the effectiveness of BMI, BAIp and TMI in screening for obesity. BAIp demonstrated the least bias in estimating PBF, showing discrepancies of 3.64 % (95 % CI 3.40 %, 4.12 %) in boys and 3.95 % (95 % CI 3.79 %, 4.23 %) in girls. Conversely, BMI underestimated PBF by 3.89 % (95 % CI 3.70 %, 4.37 %) in boys and 4.81 % (95 % CI 4.59 %, 5.09 %) in girls, while TMI also underestimated PBF by 5.15 % (95 % CI 4.90 %, 5.52 %) in boys and 5.68 % (95 % CI 5.30 %, 5.91 %) in girls. BAIp exhibited the highest AUC values (AUC = 0.867-0.996) in boys, whereas in girls, there was no statistically significant difference between BMI (AUC = 0.936, 95 % CI 0.921, 0.948) and BAIp (AUC = 0.901, 95 % CI 0.883, 0.916) in girls (P = 0.054). In summary, when considering the identification of obesity, BAIp shows promise as a screening tool for both boys and girls. FAU - Wang, Yimin AU - Wang Y AUID- ORCID: 0000-0002-8888-1986 AD - School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. AD - Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei430030, People's Republic of China. FAU - Xu, Ke AU - Xu K AD - School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. AD - Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei430030, People's Republic of China. FAU - Wang, Miyuan AU - Wang M AD - School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. AD - Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei430030, People's Republic of China. FAU - Tuerxun, Paiziyeti AU - Tuerxun P AD - School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. AD - Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei430030, People's Republic of China. FAU - Dong, Wenli AU - Dong W AD - School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. AD - Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei430030, People's Republic of China. FAU - Wei, Mengna AU - Wei M AD - School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. AD - Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei430030, People's Republic of China. FAU - Jiang, Yanfen AU - Jiang Y AUID- ORCID: 0009-0009-4136-4680 AD - School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. AD - Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei430030, People's Republic of China. FAU - Xia, Wenqi AU - Xia W AD - School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. AD - Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei430030, People's Republic of China. FAU - Zhou, Jiameng AU - Zhou J AD - School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. AD - Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei430030, People's Republic of China. FAU - Zhang, Jianduan AU - Zhang J AD - School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. AD - Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei430030, People's Republic of China. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241111 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM MH - Humans MH - Child, Preschool MH - Female MH - Male MH - *Body Mass Index MH - *Adiposity MH - Cross-Sectional Studies MH - *Pediatric Obesity/diagnosis MH - *Adipose Tissue MH - Electric Impedance MH - China/epidemiology MH - Child MH - Mass Screening/methods MH - ROC Curve MH - Anthropometry/methods MH - Reproducibility of Results OTO - NOTNLM OT - BAIp OT - BMI OT - Body fat OT - Children OT - Obesity EDAT- 2024/11/13 13:50 MHDA- 2024/12/20 12:21 CRDT- 2024/11/11 10:02 PHST- 2024/12/20 12:21 [medline] PHST- 2024/11/13 13:50 [pubmed] PHST- 2024/11/11 10:02 [entrez] AID - S0007114524002046 [pii] AID - 10.1017/S0007114524002046 [doi] PST - ppublish SO - Br J Nutr. 2024 Dec 14;132(11):1466-1473. doi: 10.1017/S0007114524002046. Epub 2024 Nov 11. PMID- 39526561 OWN - NLM STAT- MEDLINE DCOM- 20250109 LR - 20260724 IS - 1536-4801 (Electronic) IS - 0277-2116 (Linking) VI - 80 IP - 1 DP - 2025 Jan TI - Food insecurity in a diverse community pediatric gastroenterology clinic: Screening strategies and insights. PG - 80-86 LID - 10.1002/jpn3.12401 [doi] AB - OBJECTIVES: We aimed to evaluate the prevalence of food insecurity (FI) in the community pediatric gastroenterology (GI) subspecialty clinic at Texas Children's Hospital (TCH) West Campus and to assess the utilization of services through our partnership with a local food bank. METHODS: From July 1, 2023, to February 29, 2024, all patients seen in the pediatric GI clinic at TCH West Campus were screened for FI using the validated Hunger Vital Sign tool and given the opportunity to consult with a local food bank representative. A retrospective chart review was then performed on patients who completed the implemented FI screening process. RESULTS: 13.4% of the total patients screened positive for FI. Hispanic patients (p < 0.0001), patients with the preferred language of Spanish (p < 0.0001), those enrolled in Medicaid or Children's Health Insurance Program (p < 0.0001), and patients with obesity (body mass index >/= 30.0, p = 0.0003) were more likely to screen positive for FI. Poor weight gain/failure to thrive and steatotic liver disease were significantly more common in those with FI (p < 0.0001 and p = 0.0003, respectively), while celiac disease, abdominal pain, and blood in stool were more common in those without FI (p = 0.0003, 0.0475, and 0.0404, respectively). As a result of our implemented FI screening process, 68.4% of those screening positive opted for resource referral, with 50.7% successfully receiving assistance in combating FI. CONCLUSIONS: Identifying the potential impact of FI in common pediatric GI conditions calls for proactive screening and more holistic, patient-centered approaches in clinical practice. CI - (c) 2024 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Watson, Ashleigh AU - Watson A AUID- ORCID: 0000-0001-6272-466X AD - Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA. FAU - Jazayeri, Amir AU - Jazayeri A AD - Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA. FAU - Raj, Priya AU - Raj P AUID- ORCID: 0009-0000-6149-2457 AD - Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA. LA - eng GR - None/ PT - Journal Article DEP - 20241111 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM MH - Humans MH - *Food Insecurity MH - Retrospective Studies MH - Female MH - Male MH - Child MH - Texas/epidemiology MH - Child, Preschool MH - *Gastroenterology/statistics & numerical data MH - Adolescent MH - *Mass Screening/methods MH - Prevalence MH - Infant MH - Hospitals, Pediatric/statistics & numerical data MH - Pediatrics/statistics & numerical data/methods OTO - NOTNLM OT - Hispanic OT - access to food OT - failure to thrive OT - social determinants of health OT - steatotic liver disease EDAT- 2024/11/13 13:56 MHDA- 2025/01/10 00:21 CRDT- 2024/11/11 07:23 PHST- 2024/09/24 00:00 [revised] PHST- 2024/06/28 00:00 [received] PHST- 2024/10/11 00:00 [accepted] PHST- 2025/01/10 00:21 [medline] PHST- 2024/11/13 13:56 [pubmed] PHST- 2024/11/11 07:23 [entrez] AID - 10.1002/jpn3.12401 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2025 Jan;80(1):80-86. doi: 10.1002/jpn3.12401. Epub 2024 Nov 11. PMID- 39526506 OWN - NLM STAT- MEDLINE DCOM- 20241218 LR - 20260526 IS - 1613-4133 (Electronic) IS - 1613-4125 (Linking) VI - 68 IP - 23 DP - 2024 Dec TI - Interaction between Dietary Magnesium Intake and Genetic Risk Score on the Risk of Gestational Diabetes. PG - e2400589 LID - 10.1002/mnfr.202400589 [doi] AB - SCOPE: We aim to assess the interaction between genetic risk and magnesium (Mg) intake during pregnancy on the development of gestational diabetes mellitus (GDM). METHODS AND RESULTS: Three thousand ninety-six pregnant women from Tongji Maternal and Child Health Cohort are involved in our study. One hundred twelve susceptibility genetic variants of diabetes are selected and genotyped through Asian Screening Array bead chip. Mg intake were assessed by a validated food frequency questionnaire conducted at gestational weeks 25.1 +/- 2.7 before GDM diagnosis. The study identifies 22 variants associated with GDM. Weighted genetic risk score (GRS) based on these 22 SNPs is associated with higher occurrence of GDM. There is an interaction between GRS and Mg intake on GDM risk (p-interaction = 0.019). Pregnant women with high GRS (>/=23.48) and insufficient Mg intake (<370.0 mg d(-1)) have a 1.74 (95% confidence interval [CI]: 1.02, 2.98) fold risk of GDM after adjusting for potential confounders. No such relationship exists among pregnant women with low GRS (<23.48) (adjusted relative risk [RR] = 1.18; 95% CI: 0.73, 1.92). CONCLUSION: Genetic predisposition to GDM is modified by Mg intake. This suggests that clinical nutrition guidance may benefit from being tailored by screening women with high diabetic genetic risk. CI - (c) 2024 Wiley-VCH GmbH. FAU - Cao, Xiyu AU - Cao X AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030, China. FAU - Lin, Lixia AU - Lin L AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030, China. FAU - Wu, Meng AU - Wu M AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030, China. FAU - Liu, Jin AU - Liu J AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030, China. FAU - Zhong, Chunrong AU - Zhong C AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030, China. FAU - Yang, Nianhong AU - Yang N AUID- ORCID: 0000-0003-1671-8028 AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030, China. LA - eng SI - ClinicalTrials.gov/NCT03099837 GR - NSFC81673159/National Natural Science Foundation of China/ GR - 2013FY114200/National Program on Basic Research Project of China/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241111 PL - Germany TA - Mol Nutr Food Res JT - Molecular nutrition & food research JID - 101231818 RN - I38ZP9992A (Magnesium) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Diabetes, Gestational/genetics MH - *Magnesium/administration & dosage MH - Adult MH - *Genetic Predisposition to Disease MH - *Polymorphism, Single Nucleotide MH - Risk Factors MH - Diet MH - Genetic Risk Score OTO - NOTNLM OT - genetic risk score OT - gene-nutrient interaction OT - gestational diabetes mellitus OT - magnesium intake OT - pregnancy EDAT- 2024/11/13 13:55 MHDA- 2024/12/18 11:32 CRDT- 2024/11/11 06:54 PHST- 2024/09/28 00:00 [revised] PHST- 2024/07/29 00:00 [received] PHST- 2024/12/18 11:32 [medline] PHST- 2024/11/13 13:55 [pubmed] PHST- 2024/11/11 06:54 [entrez] AID - 10.1002/mnfr.202400589 [doi] PST - ppublish SO - Mol Nutr Food Res. 2024 Dec;68(23):e2400589. doi: 10.1002/mnfr.202400589. Epub 2024 Nov 11. PMID- 39521350 OWN - NLM STAT- MEDLINE DCOM- 20241130 LR - 20260531 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 204 DP - 2025 Jan 1 TI - A mesocorticolimbic insulin receptor gene co-expression network moderates the association between early life adversity and food approach eating behaviour style in childhood. PG - 107762 LID - S0195-6663(24)00566-X [pii] LID - 10.1016/j.appet.2024.107762 [doi] AB - Insulin receptors, located in brain regions associated with reward sensitivity and decision-making, facilitate insulin action in the brain, modulating intracellular signaling cascades, gene expression, and neural activity. Here, we tested if variations in the expression of the insulin receptor gene network in the prefrontal cortex (PFC) and striatum (STR) moderate the association between early life adversity and eating behaviour in childhood and if this moderation is sex-specific. Participants from the Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN) and Basal Influences on the Baby's Development (BIBO) were included as two independent cohorts. A biologically-informed polygenic score reflecting functional variation of the mesocorticolimbic insulin receptor gene network was created by using insulin receptor co-expression data from the PFC and STR in mice, and validated in humans through filtering by homologous expression in PFC using well-known databases. Early life adversity exposure was measured as a composite score. Eating behaviour was characterized using the Child Eating Behaviour Questionnaire administered to mothers of children aged 4 and 6 years in MAVAN, and 6 years in BIBO. We found that only in those with high expression of the mesocorticolimbic insulin receptor gene network a higher early adversity score associated with a higher desire to drink in 4-year boys and 6-year girls, as well as a higher food approach score and food approach/food avoidance ratio in 4-year girls. Also, a higher early life adversity was associated with higher food responsiveness, food approach score and food approach/food avoidance ratio at 6 years in the MAVAN full sample. The moderation observed on desire to drink was partially replicated in BIBO children aged 6 years. Identifying individual differences in response to early adversity may help to prioritize individuals at high risk for long-term disease and design suitable interventions. CI - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Jaramillo-Ospina, Angela Marcela AU - Jaramillo-Ospina AM AD - Department of Psychiatry, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada. FAU - Dalle Molle, Roberta AU - Dalle Molle R AD - Douglas Research Centre, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada. FAU - Patel, Sachin AU - Patel S AD - Douglas Research Centre, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada. FAU - Kelly, Shona AU - Kelly S AD - Department of Psychology, Faculty of Arts, McGill University, Montreal, QC, Canada. FAU - Pokhvisneva, Irina AU - Pokhvisneva I AD - Douglas Research Centre, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada. FAU - de Weerth, Carolina AU - de Weerth C AD - Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands. FAU - Silveira, Patricia Pelufo AU - Silveira PP AD - Department of Psychiatry, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada; Douglas Research Centre, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada; Ludmer Centre for Neuroinformatics and Mental Health, McGill University, Montreal, QC, Canada. Electronic address: patricia.silveira@mcgill.ca. LA - eng PT - Journal Article DEP - 20241107 PL - England TA - Appetite JT - Appetite JID - 8006808 RN - EC 2.7.10.1 (Receptor, Insulin) SB - IM MH - Humans MH - *Receptor, Insulin/genetics/metabolism MH - Male MH - Female MH - Child MH - *Prefrontal Cortex/metabolism MH - Child, Preschool MH - *Feeding Behavior/psychology MH - *Adverse Childhood Experiences MH - Gene Regulatory Networks MH - Corpus Striatum/metabolism MH - Child Behavior MH - Surveys and Questionnaires OTO - NOTNLM OT - Early life adversity OT - Feeding behaviour OT - Gene network OT - Insulin receptor OT - Mesocorticolimbic system OT - Polygenic score COIS- Declaration of competing interest The authors report there are no competing interests to declare. EDAT- 2024/11/13 13:53 MHDA- 2024/12/01 15:22 CRDT- 2024/11/09 19:29 PHST- 2024/01/31 00:00 [received] PHST- 2024/08/27 00:00 [revised] PHST- 2024/11/06 00:00 [accepted] PHST- 2024/12/01 15:22 [medline] PHST- 2024/11/13 13:53 [pubmed] PHST- 2024/11/09 19:29 [entrez] AID - S0195-6663(24)00566-X [pii] AID - 10.1016/j.appet.2024.107762 [doi] PST - ppublish SO - Appetite. 2025 Jan 1;204:107762. doi: 10.1016/j.appet.2024.107762. Epub 2024 Nov 7. PMID- 39519605 OWN - NLM STAT- MEDLINE DCOM- 20241109 LR - 20260226 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 21 DP - 2024 Nov 2 TI - Validation of a Food Frequency Questionnaire: VioScreen-Allergy. LID - 10.3390/nu16213772 [doi] LID - 3772 AB - BACKGROUND/OBJECTIVES: An adapted version of an online pictorial food frequency questionnaire (FFQ), VioScreen-Allergy, assesses total dietary intake and intake of allergens and foods in the maternal diet index (MDI), linked to offspring allergy. This study assessed intermethod reliability, test-retest reliability, and external validity of the VioScreen-Allergy. METHODS: Females of childbearing age were recruited at Denver Health and Children's Hospital, Colorado, USA, and were asked to complete four 24 h recalls and two VioScreen-Allergy FFQs over the course of a month. All those with at least two 24 h dietary recalls and both VioScreen-Allergy assessments were analyzed. Energy-adjusted and non-adjusted linear mixed models (1) compared MDI scores and intake of nutrients and allergens as measures of intermethod reliability; (2) evaluated VioScreen-Allergy test-retest reliability as differences between repeated measurements; and (3) assessed external validity by modeling associations between VioScreen-Allergy-derived intake of beta-carotene and orange vegetables and Veggie Meter((R))-assessed skin carotenoids. Bonferroni corrections controlled multiple comparisons within the assessment. RESULTS: Of 53 participants enrolled, 25 demographically dissimilar participants were included in the analysis. There were no significant differences between 24 h recall and VioScreen-Allergy mean intakes of macronutrients, micronutrients, allergens, or MDI, except for Vitamin C, niacin, and cashew allergen protein. There were no significant differences between repeated measurements of VioScreen-Allergy, either energy-adjusted or unadjusted. Both beta-carotene and orange vegetable servings were significantly associated with Veggie Meter((R)). CONCLUSIONS: Although non-significance could have been due to low power, clinical as well as statistical assessments of intermethod reliability, test-retest reliability, and external validity suggest that VioScreen-Allergy has reasonable utility for trials assessing food allergens and MDI in the context of overall intake. The VioScreen questionnaire can also be used in future studies to assess macro- and micronutrient intake. Additional validation studies assessing different portion sizes and foods eaten by infants and young children are currently undergoing. FAU - Pickett-Nairne, Kaci AU - Pickett-Nairne K AUID- ORCID: 0009-0000-1451-0229 AD - Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO 80045, USA. FAU - Glueck, Deborah AU - Glueck D AD - Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO 80045, USA. FAU - Thomson, Jessica AU - Thomson J AUID- ORCID: 0000-0002-3754-8913 AD - Delta Human Nutrition Research Program, USDA Agricultural Research Service, Stoneville, MS 38776, USA. FAU - Weiss, Rick AU - Weiss R AD - Viocare, Inc., Princeton, NJ 08542, USA. FAU - Fuller, Kelly N Z AU - Fuller KNZ AD - Viocare, Inc., Princeton, NJ 08542, USA. FAU - Fabbri, Stefka AU - Fabbri S AD - Obstetrics & Gynecology, Denver Health Hospital, Denver, CO 80204, USA. FAU - Schaefer, Claudia AU - Schaefer C AD - Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO 80045, USA. FAU - Evans, Courtney AU - Evans C AUID- ORCID: 0009-0000-1107-6703 AD - Colorado Child Health Research Institute, Children's Hospital Colorado, Aurora, CO 80045, USA. FAU - Bowhay, Emily AU - Bowhay E AUID- ORCID: 0009-0006-9297-2289 AD - Colorado Child Health Research Institute, Children's Hospital Colorado, Aurora, CO 80045, USA. FAU - Martinez, Monica AU - Martinez M AUID- ORCID: 0000-0002-1359-048X AD - Obstetrics & Gynecology, Denver Health Hospital, Denver, CO 80204, USA. FAU - Moore, Wendy AU - Moore W AUID- ORCID: 0000-0002-7509-1096 AD - Colorado Child Health Research Institute, Children's Hospital Colorado, Aurora, CO 80045, USA. FAU - Fleischer, David AU - Fleischer D AD - Section of Pediatric Allergy and Immunology, Children's Hospital Colorado, University of Colorado, Boulder, CO 80309, USA. FAU - Venter, Carina AU - Venter C AD - Section of Pediatric Allergy and Immunology, Children's Hospital Colorado, University of Colorado, Boulder, CO 80309, USA. LA - eng GR - UL1 TR002535/TR/NCATS NIH HHS/United States GR - UL1TR002535/University of Colorado/ PT - Journal Article PT - Validation Study DEP - 20241102 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Allergens) SB - IM MH - Humans MH - Female MH - Reproducibility of Results MH - Adult MH - Surveys and Questionnaires/standards MH - *Diet/statistics & numerical data MH - Young Adult MH - Allergens/administration & dosage/analysis MH - Diet Surveys/standards MH - Food Hypersensitivity MH - Nutrition Assessment PMC - PMC11547440 OTO - NOTNLM OT - external validity OT - food frequency questionnaire OT - intermethod reliability OT - maternal diet index OT - test-retest reliability COIS- David Fleischer has received research support from ARS Pharmaceuticals and DBV Technologies; serves as an unpaid advisory board member for the Food Allergy & Anaphylaxis Connection Team and the National Peanut Board; receives royalties from UpToDate; and received personal fees as a consultant to Aquestive, ARS Pharmaceuticals, Bryn Pharma, DBV Technologies, Genentech, and Nasus outside of the submitted work. Venter reports grants from Reckitt Benckiser, grants from Food Allergy Research and Education, and grants from the National Peanut Board during the conduct of the study; personal fees from Reckitt Benckiser, personal fees from Nestle Nutrition Institute, personal fees from Danone, personal fees from Abbott Nutrition, personal fees from Else Nutrition, and personal fees from Before Brands, outside the submitted work. Rick Weiss is the president and majority owner of Viocare, Inc., which was compensated for the development of the infant allergy food frequency questionnaire (FFQ) based on VioScreen. The FFQ was used and validated in the study described in this paper. This commercial relationship represents a conflict of interest. The other authors declare no interests. None of the support listed played any role in the design, execution, interpretation, or writing of the study. EDAT- 2024/11/13 13:56 MHDA- 2024/11/13 13:57 PMCR- 2024/11/02 CRDT- 2024/11/09 01:15 PHST- 2024/10/05 00:00 [received] PHST- 2024/10/25 00:00 [revised] PHST- 2024/10/29 00:00 [accepted] PHST- 2024/11/13 13:57 [medline] PHST- 2024/11/13 13:56 [pubmed] PHST- 2024/11/09 01:15 [entrez] PHST- 2024/11/02 00:00 [pmc-release] AID - nu16213772 [pii] AID - nutrients-16-03772 [pii] AID - 10.3390/nu16213772 [doi] PST - epublish SO - Nutrients. 2024 Nov 2;16(21):3772. doi: 10.3390/nu16213772. PMID- 39519583 OWN - NLM STAT- MEDLINE DCOM- 20241109 LR - 20241116 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 21 DP - 2024 Oct 31 TI - Updated-Food Choice Questionnaire: Cultural Adaptation and Validation in a Spanish-Speaking Population from Mexico. LID - 10.3390/nu16213749 [doi] LID - 3749 AB - BACKGROUND: Determinants and motives related to food selection have evolved in a globalized and changing world. The traditional and useful Food Choice Questionnaire (FCQ), created in 1995, needs to be updated, adapted to new scenarios, and validated. OBJECTIVES: This study aimed to: (1) assess face validity (FV) of the original 36-item FCQ, (2) generate an Updated-FCQ (U-FCQ) and assess its content validity (CV) (instrument suitability), and (3) evaluate its construct validity and reliability in a Spanish-speaking population from Mexico. METHODS: FV involved a panel of nutrition professionals (NPs) rating the original items' clarity, relevance, specificity, and representativeness. A literature review process updated the FCQ by adding new items. CV with a second NP panel allowed calculating content validity ratio (CVR). Construct validation was performed via exploratory and confirmatory factor analysis (EFA-CFA). Internal consistency through Cronbach's alpha (CA) and test-retest reliability via intra-class correlation (ICC) were assessed. RESULTS: The FV (n = 8) resulted in the modification of 11 original items. The literature review added 36 new items (15 from previous adaptations and 21 original items). The CV (n = 13) identified nine items (non-acceptable CVR), prompting reformulation of seven and removal of two. The NPs' feedback added six new items. The EFA-CFA (n = 788) developed a 75-item U-FCQ with eight dimensions: sensory appeal, mood, health and nutritional content, price, food identity, environmental and wildlife awareness, convenience, and image management. CA ranged from 0.74-0.97 (good-excellent) and ICC from 0.51-0.78 (moderate-good). CONCLUSIONS: This study provides a useful instrument for the assessment of food choices and lays the groundwork for future cross-cultural comparisons, expanding its applicability in wider settings. FAU - Salas-Garcia, Miguel Amaury AU - Salas-Garcia MA AUID- ORCID: 0000-0003-1230-9593 AD - Doctorado en Ciencias de la Nutricion Traslacional, Departamento de Clinicas de la Reproduccion Humana, Crecimiento y Desarrollo Infantil, Division de Disciplinas Clinicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Mexico. AD - Laboratorio de Evaluacion del Estado Nutricio, Departamento de Clinicas de la Reproduccion Humana, Crecimiento y Desarrollo Infantil, Division de Disciplinas Clinicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Mexico. AD - Instituto de Nutrigenetica y Nutrigenomica Traslacional, Departamento de Biologia Molecular y Genomica, Division de Disciplinas Basicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Mexico. FAU - Bernal-Orozco, Maria Fernanda AU - Bernal-Orozco MF AUID- ORCID: 0000-0002-3894-175X AD - Doctorado en Ciencias de la Nutricion Traslacional, Departamento de Clinicas de la Reproduccion Humana, Crecimiento y Desarrollo Infantil, Division de Disciplinas Clinicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Mexico. AD - Laboratorio de Evaluacion del Estado Nutricio, Departamento de Clinicas de la Reproduccion Humana, Crecimiento y Desarrollo Infantil, Division de Disciplinas Clinicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Mexico. AD - Instituto de Nutrigenetica y Nutrigenomica Traslacional, Departamento de Biologia Molecular y Genomica, Division de Disciplinas Basicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Mexico. AD - Doctorado en Ciencias de la Salud Publica, Departamento de Salud Publica, Division de Disciplinas para el Desarrollo, Promocion y Preservacion de la Salud, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Mexico. FAU - Diaz-Lopez, Andres AU - Diaz-Lopez A AUID- ORCID: 0000-0002-7500-5629 AD - Nutrition and Mental Health Research Group (NUTRISAM), Universitat Rovira i Virgili (URV), 43204 Reus, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), 43204 Reus, Spain. AD - CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain. FAU - Betancourt-Nunez, Alejandra AU - Betancourt-Nunez A AUID- ORCID: 0000-0001-6592-3031 AD - Doctorado en Ciencias de la Nutricion Traslacional, Departamento de Clinicas de la Reproduccion Humana, Crecimiento y Desarrollo Infantil, Division de Disciplinas Clinicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Mexico. AD - Laboratorio de Evaluacion del Estado Nutricio, Departamento de Clinicas de la Reproduccion Humana, Crecimiento y Desarrollo Infantil, Division de Disciplinas Clinicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Mexico. AD - Instituto de Nutrigenetica y Nutrigenomica Traslacional, Departamento de Biologia Molecular y Genomica, Division de Disciplinas Basicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Mexico. AD - Doctorado en Ciencias de la Salud Publica, Departamento de Salud Publica, Division de Disciplinas para el Desarrollo, Promocion y Preservacion de la Salud, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Mexico. AD - Centro de Investigacion Educativa y Bienestar Universitario, Departamento de Disciplinas Filosofico, Metodologico e Instrumentales, Division de Disciplinas Basicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Mexico. FAU - Nava-Amante, Pablo Alejandro AU - Nava-Amante PA AUID- ORCID: 0000-0002-7280-6172 AD - Doctorado en Ciencias de la Nutricion Traslacional, Departamento de Clinicas de la Reproduccion Humana, Crecimiento y Desarrollo Infantil, Division de Disciplinas Clinicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Mexico. AD - Laboratorio de Evaluacion del Estado Nutricio, Departamento de Clinicas de la Reproduccion Humana, Crecimiento y Desarrollo Infantil, Division de Disciplinas Clinicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Mexico. AD - Instituto de Nutrigenetica y Nutrigenomica Traslacional, Departamento de Biologia Molecular y Genomica, Division de Disciplinas Basicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Mexico. FAU - Danquah, Ina AU - Danquah I AUID- ORCID: 0000-0003-3222-3498 AD - Heidelberg Institute of Global Health (HIGH), Heidelberg University Hospital and Medical Faculty, Heidelberg University, 69120 Heidelberg, Germany. FAU - Martinez, J Alfredo AU - Martinez JA AD - CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain. AD - Centro de Investigacion de Endocrinologia y Nutricion Clinica, Universidad de Valladolid, 47005 Valladolid, Spain. AD - Precision Nutrition and Cardiometabolic Health Program, Research Institute on Food and Health Sciences IMDEA Food, UAM + CSIC, 28049 Madrid, Spain. FAU - de Luis, Daniel A AU - de Luis DA AUID- ORCID: 0000-0002-1745-9315 AD - Centro de Investigacion de Endocrinologia y Nutricion Clinica, Universidad de Valladolid, 47005 Valladolid, Spain. FAU - Vizmanos, Barbara AU - Vizmanos B AUID- ORCID: 0000-0003-0680-0802 AD - Doctorado en Ciencias de la Nutricion Traslacional, Departamento de Clinicas de la Reproduccion Humana, Crecimiento y Desarrollo Infantil, Division de Disciplinas Clinicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Mexico. AD - Laboratorio de Evaluacion del Estado Nutricio, Departamento de Clinicas de la Reproduccion Humana, Crecimiento y Desarrollo Infantil, Division de Disciplinas Clinicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Mexico. AD - Instituto de Nutrigenetica y Nutrigenomica Traslacional, Departamento de Biologia Molecular y Genomica, Division de Disciplinas Basicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Mexico. AD - Doctorado en Ciencias de la Salud Publica, Departamento de Salud Publica, Division de Disciplinas para el Desarrollo, Promocion y Preservacion de la Salud, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Mexico. AD - Centro de Investigacion Educativa y Bienestar Universitario, Departamento de Disciplinas Filosofico, Metodologico e Instrumentales, Division de Disciplinas Basicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Mexico. AD - Centro de Investigacion de Endocrinologia y Nutricion Clinica, Universidad de Valladolid, 47005 Valladolid, Spain. LA - eng GR - UDG-PTC-1511/Secretariat of Public Education/ PT - Journal Article PT - Validation Study DEP - 20241031 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Mexico MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - *Food Preferences/psychology MH - Female MH - Adult MH - Male MH - Middle Aged MH - Young Adult MH - Choice Behavior MH - Psychometrics MH - Language MH - Adolescent PMC - PMC11548158 OTO - NOTNLM OT - factor analysis OT - food choice questionnaire OT - food selection OT - reliability OT - validity COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data in the writing of the manuscript, or the decisions to publish the results. EDAT- 2024/11/13 13:52 MHDA- 2024/11/13 13:53 PMCR- 2024/10/31 CRDT- 2024/11/09 01:15 PHST- 2024/10/10 00:00 [received] PHST- 2024/10/26 00:00 [revised] PHST- 2024/10/28 00:00 [accepted] PHST- 2024/11/13 13:53 [medline] PHST- 2024/11/13 13:52 [pubmed] PHST- 2024/11/09 01:15 [entrez] PHST- 2024/10/31 00:00 [pmc-release] AID - nu16213749 [pii] AID - nutrients-16-03749 [pii] AID - 10.3390/nu16213749 [doi] PST - epublish SO - Nutrients. 2024 Oct 31;16(21):3749. doi: 10.3390/nu16213749. PMID- 39519542 OWN - NLM STAT- MEDLINE DCOM- 20241109 LR - 20241116 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 21 DP - 2024 Oct 30 TI - Improvement in Symptoms of Depression and Anxiety and Cardiometabolic Risk Factors in Children and Adolescents with Overweight and Obesity Following the Implementation of a Multidisciplinary Personalized Lifestyle Intervention Program. LID - 10.3390/nu16213710 [doi] LID - 3710 AB - Background/Objectives: Childhood obesity is one of the most challenging contemporary public health problems. Children and adolescents with obesity experience multiple psychosocial difficulties, such as low self-esteem, depression, anxiety, and behavioral problems, which persist for a long time. The aim of the study was to assess the effect of a multidisciplinary personalized lifestyle intervention for depressive and anxiety symptoms, as evaluated by psychometric questionnaires, and their effect and association with cardiometabolic parameters in children and adolescents with overweight and obesity before and after the intervention. Methods: Six hundred and eleven (n = 611) children and adolescents (mean age +/- SE: 10.39 +/- 0.10 years; 51.5% females, 46.6% pubertal) were studied prospectively. Subjects were classified as being obese (50.2%), overweight (33.5%), or having a normal BMI (16.2%) according to IOTF criteria. All participants entered a 1-year lifestyle intervention program; laboratory investigations were obtained at the beginning and end of the study and two psychometric questionnaires were completed, the CDI and SCARED, which evaluate symptoms of depression and anxiety, respectively. Results: Following the lifestyle intervention, a significant decrease was noted in anxiety scores in all subjects and in depression scores in youth with obesity, as well as in adolescents with obesity, while females displayed a reduced response to the intervention. Insulin resistance and metabolic syndrome parameters, cortisol, PRL, and LH concentrations were positive predictors for depressive and anxiety symptoms. Conclusions: The implementation of a multidisciplinary personalized lifestyle intervention program in the management of childhood obesity is associated with a significant decrease in cardiometabolic and psychosocial comorbidities in children with and without excess adiposity. The improvement in mental health is likely mediated by an improvement in energy metabolism with subsequent improvement in neuroinflammation owing to lifestyle changes. FAU - Vourdoumpa, Aikaterini AU - Vourdoumpa A AUID- ORCID: 0000-0002-6277-9959 AD - Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece. FAU - Paltoglou, George AU - Paltoglou G AUID- ORCID: 0000-0003-4300-7061 AD - Diabetes and Metabolism Clinic, Second Department of Pediatrics, National and Kapodistrian University of Athens, "P. & A. Kyriakou" Children's Hospital, 11527 Athens, Greece. FAU - Manou, Maria AU - Manou M AUID- ORCID: 0000-0002-9584-0373 AD - Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece. FAU - Mantzou, Emilia AU - Mantzou E AUID- ORCID: 0000-0001-6606-8647 AD - Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece. FAU - Kassari, Penio AU - Kassari P AUID- ORCID: 0000-0003-2464-1825 AD - Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece. AD - Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece. FAU - Papadopoulou, Marina AU - Papadopoulou M AD - Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece. FAU - Kolaitis, Gerasimos AU - Kolaitis G AD - Department of Child Psychiatry, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece. FAU - Charmandari, Evangelia AU - Charmandari E AUID- ORCID: 0000-0002-0851-6998 AD - Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece. AD - Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece. LA - eng GR - Program entitled "Development of a National System for the Prevention and Management of Overweight and Obesity in Childhood and Adolescence in Greece", with the promotional phrase "Lose Weight - Gain Life" (MIS 370545)/National Strategic Reference Framework (NSRF) 2007-2013 under the Operational Program "Human Resources Development" (EP.AN.A.D) 2007-2013 and was co-funded by the European Social Fund (ESF) and National Funding/ GR - project code: T1EDK-01386, MIS: 5030543, Acronym: PEDOBESITY, Program entitled "Development of Intelligent Multi-level Information Systems and Specialized Artificial Intelligence Algorithms for Personalized Management of Obesity in Childhood and Adolescen/European Regional Development Fund of the European Union and Greek national funds through the Operational Program "Competitiveness, Entrepreneurship, and Innovation" (EPA-nEK 2014-2020), under the call RESEARCH-CREATE-INNOVATE/ PT - Journal Article DEP - 20241030 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Male MH - Child MH - *Pediatric Obesity/psychology/therapy MH - Adolescent MH - *Depression/therapy MH - *Anxiety/therapy MH - *Cardiometabolic Risk Factors MH - *Life Style MH - Overweight/therapy/psychology MH - Prospective Studies MH - Surveys and Questionnaires PMC - PMC11547602 OTO - NOTNLM OT - anxiety OT - childhood obesity OT - depression OT - lifestyle intervention OT - mental health COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2024/11/13 13:57 MHDA- 2024/11/13 13:58 PMCR- 2024/10/30 CRDT- 2024/11/09 01:15 PHST- 2024/09/25 00:00 [received] PHST- 2024/10/21 00:00 [revised] PHST- 2024/10/23 00:00 [accepted] PHST- 2024/11/13 13:58 [medline] PHST- 2024/11/13 13:57 [pubmed] PHST- 2024/11/09 01:15 [entrez] PHST- 2024/10/30 00:00 [pmc-release] AID - nu16213710 [pii] AID - nutrients-16-03710 [pii] AID - 10.3390/nu16213710 [doi] PST - epublish SO - Nutrients. 2024 Oct 30;16(21):3710. doi: 10.3390/nu16213710. PMID- 39519528 OWN - NLM STAT- MEDLINE DCOM- 20241109 LR - 20260923 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 21 DP - 2024 Oct 30 TI - Towards Understanding the Motivators of Sustainable Consumer Behavior-Validation of the Food Eco-Guilt Scale. LID - 10.3390/nu16213695 [doi] LID - 3695 AB - BACKGROUND/OBJECTIVES: The growing concern about the environmental impacts of consumption has led to the emergence of so-called "eco-guilt"-a psychological construct reflecting the guilt felt by individuals about the environmental consequences of their choices, which plays a prominent role among the factors influencing pro-environmental behavior. Although eco-guilt has already emerged in other service sectors, such as tourism, and general scales exist to measure it, no such scale exists in the context of food consumption. The aim of this research is to develop and validate a scale to measure eco-guilt related to food consumption. METHODS: To create the scale in an objective way, we used the Sustainable Development Goals as a framework. Data were collected from university students; a questionnaire was completed online by 367 respondents. The responses were analyzed from several different perspectives, using multiple methods following the principle of triangulation. For the data analysis, the Psych and Mokken packages of R software (version 4.4.0) were used. RESULTS: The constructed scale was based on 13 items. An overview of the reliability of the scale was provided using various indicators (e.g., Cronbach's alpha = 0.86, omega(h) = 0.63, omega(H asymptotic) = 0.71, and omega(t) = 0.89). Based on the analyses, we proposed a reduced form with nine items for the measurement of food-related eco-guilt. CONCLUSIONS: The results of this research provide a scale to help understand what motivates consumers to make more sustainable consumption choices. Moreover, the scale is relevant to future research focused on understanding how guilt influences future food choices. FAU - Unger-Plasek, Brigitta AU - Unger-Plasek B AUID- ORCID: 0000-0002-6534-7107 AD - Institute of Agricultural and Food Economics, Hungarian University of Agriculture and Life Sciences, Villanyi Street 29-43, H-1118 Budapest, Hungary. FAU - Temesi, Agoston AU - Temesi A AUID- ORCID: 0000-0001-6128-6653 AD - Institute of Agricultural and Food Economics, Hungarian University of Agriculture and Life Sciences, Villanyi Street 29-43, H-1118 Budapest, Hungary. FAU - Lakner, Zoltan AU - Lakner Z AD - Institute of Agricultural and Food Economics, Hungarian University of Agriculture and Life Sciences, Villanyi Street 29-43, H-1118 Budapest, Hungary. LA - eng GR - UNKP-23-4/National Research, Development and Innovation Fund/ GR - OTKA K 132915/Hungarian National Research, Development and Innovation Office/ PT - Journal Article PT - Validation Study DEP - 20241030 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Consumer Behavior MH - Female MH - Surveys and Questionnaires/standards MH - Male MH - *Motivation MH - Reproducibility of Results MH - Young Adult MH - Adult MH - *Sustainable Development MH - Guilt MH - Food Preferences/psychology MH - Choice Behavior MH - Students/psychology MH - Adolescent PMC - PMC11547507 OTO - NOTNLM OT - Mokken scale analysis OT - Psych package OT - food eco-guilt OT - item response theory OT - scale validation COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2024/11/13 13:58 MHDA- 2024/11/13 13:59 PMCR- 2024/10/30 CRDT- 2024/11/09 01:14 PHST- 2024/09/24 00:00 [received] PHST- 2024/10/21 00:00 [revised] PHST- 2024/10/25 00:00 [accepted] PHST- 2024/11/13 13:59 [medline] PHST- 2024/11/13 13:58 [pubmed] PHST- 2024/11/09 01:14 [entrez] PHST- 2024/10/30 00:00 [pmc-release] AID - nu16213695 [pii] AID - nutrients-16-03695 [pii] AID - 10.3390/nu16213695 [doi] PST - epublish SO - Nutrients. 2024 Oct 30;16(21):3695. doi: 10.3390/nu16213695. PMID- 39519443 OWN - NLM STAT- MEDLINE DCOM- 20241109 LR - 20260226 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 21 DP - 2024 Oct 24 TI - Parental Acculturation and Its Effect on Preschool-Aged Children's Health Behaviors Among Latinos in Nevada: A Cross-Sectional Study. LID - 10.3390/nu16213610 [doi] LID - 3610 AB - BACKGROUND: Latino children in the United States (US) have a higher prevalence of overweight/obesity compared to white children. Previous studies suggest that acculturation to the US is associated with health behaviors such as diet, body mass index (BMI), and physical activity. However, the role of parental acculturation remains understudied, particularly with the use of validated measures. OBJECTIVE: The objective of this study was to evaluate parental acculturation and its association with parental interpersonal factors and health behaviors in the preschool-aged child. METHODS: Data were analyzed from 187 Latino parents in Nevada. Parents completed a self-reported, cross-sectional survey. Acculturation was assessed using Norris' 4-item validated acculturation measure. The average age of the preschool-aged children was 45.5 months, and their mean BMI percentile was 96.4% (SD +/- 18.7). The mean parental acculturation score was 2.1 (SD +/- 1.2). Children were physically active an average of 4.9 (SD +/- 2.0) days per week. After controlling for covariates, the results indicated that parental acculturation was positively associated with physical activity and sugar-sweetened beverage consumption. However, parental acculturation was not associated with child BMI percentile, or the consumption of fruits, vegetables, and sweet snacks. CONCLUSIONS: These findings can inform future research on culturally tailored intervention strategies to boost physical activity and reduce sugar-sweetened beverage intake among Latino preschool-aged children. FAU - Johansen, Christopher AU - Johansen C AUID- ORCID: 0000-0002-7501-0970 AD - Department of Social and Behavioral Health, School of Public Health, University of Nevada, Las Vegas (UNLV), Las Vegas, NV 89119, USA. FAU - Fudolig, Miguel Antonio AU - Fudolig MA AUID- ORCID: 0000-0002-0148-8090 AD - Department of Epidemiology and Biostatistics, School of Public Health, University of Nevada, Las Vegas (UNLV), Las Vegas, NV 89119, USA. FAU - Davalos, Liliana AU - Davalos L AUID- ORCID: 0009-0005-0644-6358 AD - Department of Social and Behavioral Health, School of Public Health, University of Nevada, Las Vegas (UNLV), Las Vegas, NV 89119, USA. FAU - Rodriguez Alcantar, Brisa AU - Rodriguez Alcantar B AD - Department of Social and Behavioral Health, School of Public Health, University of Nevada, Las Vegas (UNLV), Las Vegas, NV 89119, USA. LA - eng GR - L60 HD106427/HD/NICHD NIH HHS/United States GR - P20 GM103440/GM/NIGMS NIH HHS/United States GR - 5P20GM103440-17A21/NH/NIH HHS/United States PT - Journal Article DEP - 20241024 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Acculturation MH - Cross-Sectional Studies MH - *Hispanic or Latino/statistics & numerical data/psychology MH - Male MH - Female MH - Child, Preschool MH - *Parents/psychology MH - *Health Behavior/ethnology MH - Nevada/epidemiology MH - *Exercise MH - Body Mass Index MH - Diet/ethnology MH - Adult MH - Pediatric Obesity/ethnology/epidemiology MH - Feeding Behavior/ethnology MH - Snacks PMC - PMC11547616 OTO - NOTNLM OT - Latinos OT - acculturation OT - body mass index OT - early childhood OT - obesity OT - physical activity OT - sugar-sweetened beverages COIS- The authors declare no conflicts of interest. EDAT- 2024/11/13 13:51 MHDA- 2024/11/14 17:36 PMCR- 2024/10/24 CRDT- 2024/11/09 01:14 PHST- 2024/09/20 00:00 [received] PHST- 2024/10/15 00:00 [revised] PHST- 2024/10/21 00:00 [accepted] PHST- 2024/11/14 17:36 [medline] PHST- 2024/11/13 13:51 [pubmed] PHST- 2024/11/09 01:14 [entrez] PHST- 2024/10/24 00:00 [pmc-release] AID - nu16213610 [pii] AID - nutrients-16-03610 [pii] AID - 10.3390/nu16213610 [doi] PST - epublish SO - Nutrients. 2024 Oct 24;16(21):3610. doi: 10.3390/nu16213610. PMID- 39516142 OWN - NLM STAT- MEDLINE DCOM- 20250425 LR - 20260912 IS - 1873-5010 (Electronic) IS - 1569-1993 (Linking) VI - 24 IP - 2 DP - 2025 Mar TI - Associations between income level and health outcomes in people with cystic fibrosis in Turkey. PG - 295-300 LID - S1569-1993(24)01803-4 [pii] LID - 10.1016/j.jcf.2024.10.010 [doi] AB - BACKGROUND: Our study aimed to identify the social domains that pose the greatest barriers to managing and supporting pwCF, particularly in relation to income levels. METHODS: To identify associations between income and health outcomes in pwCF in our center the shorter form of the survey "Your Current Life Situation" (YCLS) was used in face-to-face interviews. Participants were also asked to complete the validated Turkish versions of the 9-item Patient Health Questionnaire (PHQ-9) and the 7-item Generalized Anxiety Disorder scale (GAD-7) to assess depression and anxiety, respectively. RESULTS: In total, 282 pwCF were included in this study. 51.1 % were female (n = 144), mean (+/-SD) age was 13.8 (+/-8.7) years and 75 % (n = 211) were <18 years old. The median (IQR) values of pwCF; FEV(1pp) (percent predictive) 83 % (41-97), BMI (body mass index) 17 kg/m(2) (15 approximately 20), BMI z-score -0.1 (-1 approximately 0.3). Of the pwCF in the study 89 % (n = 251) had an income below the poverty threshold and 21 % (n = 60) of them had an income below the hunger threshold. The results of YCLS survey showed that the highest level of insecurity was in the social domain (68.5 %, n = 193); this was followed by health and clinical care (62.1 %, n = 173), financial (37.9 %, n = 106), and food insecurity (37.2 %, n = 103). All individuals experiencing housing insecurity stated that they had requested help from local organisations. CONCLUSION: The study highlights the substantial socioeconomic challenges faced by pwCF, a significant majority live below the poverty threshold and experience high levels of social and health insecurity, underscoring the need for comprehensive support systems to address these issues. CI - Copyright (c) 2024. Published by Elsevier B.V. FAU - Metin Cakar, Neval AU - Metin Cakar N AD - Division of Pediatric Pulmonology, Marmara University Faculty of Medicine, Turkiye. FAU - Karabulut, Seyda AU - Karabulut S AD - Division of Pediatric Pulmonology, Marmara University Faculty of Medicine, Turkiye. Electronic address: seyda.karabulut@marmara.edu.tr. FAU - Yuksel Kalyoncu, Mine AU - Yuksel Kalyoncu M AD - Division of Pediatric Pulmonology, Marmara University Faculty of Medicine, Turkiye. FAU - Selcuk Balci, Merve AU - Selcuk Balci M AD - Division of Pediatric Pulmonology, Marmara University Faculty of Medicine, Turkiye. FAU - Yildiz, Ceren Ayca AU - Yildiz CA AD - Division of Pediatric Pulmonology, Marmara University Faculty of Medicine, Turkiye. FAU - Kocaman, Damla AU - Kocaman D AD - Division of Nutrition and Dietetics, Marmara University Faculty of Medicine, Turkiye. FAU - Uzunoglu, Burcu AU - Uzunoglu B AD - Selim Coremen Cystic Fibrosis Center, Marmara University Faculty of Medicine, Turkiye. FAU - Tastan, Gamze AU - Tastan G AD - Selim Coremen Cystic Fibrosis Center, Marmara University Faculty of Medicine, Turkiye. FAU - Ergenekon, Almala Pinar AU - Ergenekon AP AD - Division of Pediatric Pulmonology, Marmara University Faculty of Medicine, Turkiye. FAU - Erdem Eralp, Ela AU - Erdem Eralp E AD - Division of Pediatric Pulmonology, Marmara University Faculty of Medicine, Turkiye. FAU - Gokdemir, Yasemin AU - Gokdemir Y AD - Division of Pediatric Pulmonology, Marmara University Faculty of Medicine, Turkiye. FAU - Karakoc, Fazilet AU - Karakoc F AD - Division of Pediatric Pulmonology, Marmara University Faculty of Medicine, Turkiye. FAU - Karadag, Bulent AU - Karadag B AD - Division of Pediatric Pulmonology, Marmara University Faculty of Medicine, Turkiye. LA - eng PT - Journal Article DEP - 20241108 PL - Netherlands TA - J Cyst Fibros JT - Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society JID - 101128966 SB - IM MH - Humans MH - Turkey/epidemiology MH - Female MH - *Cystic Fibrosis/psychology/epidemiology/economics/therapy MH - Male MH - *Income/statistics & numerical data MH - Adolescent MH - Depression/epidemiology/etiology MH - Child MH - Adult MH - Anxiety/epidemiology/etiology OTO - NOTNLM OT - Cystic fibrosis OT - Health outcomes OT - Income level OT - Social determinant of health OT - Your current life situation COIS- Declaration of competing interest The authors declare no conflict of interest. EDAT- 2024/11/13 13:52 MHDA- 2025/03/29 16:14 CRDT- 2024/11/08 22:01 PHST- 2024/03/23 00:00 [received] PHST- 2024/09/08 00:00 [revised] PHST- 2024/10/22 00:00 [accepted] PHST- 2025/03/29 16:14 [medline] PHST- 2024/11/13 13:52 [pubmed] PHST- 2024/11/08 22:01 [entrez] AID - S1569-1993(24)01803-4 [pii] AID - 10.1016/j.jcf.2024.10.010 [doi] PST - ppublish SO - J Cyst Fibros. 2025 Mar;24(2):295-300. doi: 10.1016/j.jcf.2024.10.010. Epub 2024 Nov 8. PMID- 39515794 OWN - NLM STAT- MEDLINE DCOM- 20241108 LR - 20241108 IS - 1578-1267 (Electronic) IS - 0301-0546 (Linking) VI - 52 IP - 6 DP - 2024 TI - Prevalence of atopic eczema in adolescents from a very low prevalence area (Kosovo): role of wheezing, gender, exercise, and paracetamol. PG - 40-50 LID - 10.15586/aei.v52i6.1155 [doi] AB - BACKGROUND: The epidemiology of atopic eczema in adolescents in Kosovo is virtually unknown, and the risk factors for the condition in very low-prevalence areas (as it was the case) are not well studied. The objective of the present study was to better know those factors and whether the presence of comorbid wheezing symptoms modifies the factors. METHODS: The cross-sectional survey, Global Asthma Network-validated questionnaire, which includes questions on eczema symptoms and environmental factors (such as smoking, pet ownership, paracetamol usage, truck traffic, siblings, time spent using screens or watching television, and physical exercise), was administered to adolescents in the following main cities of Kosovo: Ferizaj, Gjakova, Gjilan, Peja, Prishtina, and Prizren. Additionally, height and weight were measured at school. RESULTS: Prevalence of eczema symptoms ranged from 2.2% in Ferizaj to 5.5% in Gjakova. Severe symptoms were <1% in all cities. Eczema ever ranged from 3.0% in Ferizaj to 6.4% in Prizren. Factors significantly associated with the prevalence of current eczema symptoms in the meta-analysis were males (pooled adjusted odds ratio [aOR] 0.50, 95% Confidence Interval [95% CI] 0.37-0.66); physical exercise (pooled aOR 2.79, 95% CI 1.89-4.10); and paracetamol intake (pooled 1.86, 95% CI 1.32-2.64). The corresponding figures for eczema ever were as follows: pooled aOR: 0.68, 95% CI 0.44-1.06; pooled aOR 2.07, 95% CI 1.48-2.90; and pooled aOR 1.19, 95% CI 0.88-1.60. The associations tended to be higher in the subpopulation with eczema and wheezing comorbidity. CONCLUSIONS: The prevalence of atopic eczema is very low in Kosovo and is associated with females, physical exercise, and paracetamol intake. These associations are higher when eczema and wheezing are comorbid conditions. FAU - Ahmetaj, Luljeta AU - Ahmetaj L AD - Institute of Physiology & Immunology, Faculty of Medicine, University of "Hasan Prishtina", Prishtina, Kosovo. FAU - Martinez-Torres, A Elena AU - Martinez-Torres AE AD - Paediatric Allergy and Pulmonology Units and Nurse Research Group, Virgen de la Arrixaca University Children's Hospital; and IMIB Biomedical Research Institute, Murcia, Spain. FAU - Ahmetaj, Ylli AU - Ahmetaj Y AD - AAB College. Industriale Prishtine-Fushe Kosove, Prishtine Republika e Kosoves. FAU - Gashi, Valbona AU - Gashi V AD - Institute of Physiology & Immunology, Faculty of Medicine, University of "Hasan Prishtina", Prishtina, Kosovo. FAU - Kurhasani, Xhevat AU - Kurhasani X AD - UBT Higher Education Institution, Prishtine Republika e Kosoves. FAU - Lokaj-Berisha, Violeta AU - Lokaj-Berisha V AD - Institute of Physiology & Immunology, Faculty of Medicine, University of "Hasan Prishtina", Prishtina, Kosovo. FAU - Gacaferri-Lumezi, Besa AU - Gacaferri-Lumezi B AD - Institute of Physiology & Immunology, Faculty of Medicine, University of "Hasan Prishtina", Prishtina, Kosovo. FAU - Shahini, Mirsije AU - Shahini M AD - Alergji Asthma Ylli" Polyclinic, Prishtine Republika e Kosoves. FAU - Zhjeqi, Valbona AU - Zhjeqi V AD - Institute of Physiology & Immunology, Faculty of Medicine, University of "Hasan Prishtina", Prishtina, Kosovo. FAU - Garcia-Marcos, Luis AU - Garcia-Marcos L AD - Paediatric Allergy and Pulmonology Units, Virgen de la Arrixaca University Children's Hospital, University of Murcia; and IMIB Biomedical Research Institute, Murcia, Spain. CN - Global Asthma Network Phase I Kosovo Study Group AD - Members of the Global Asthma Network Phase I Kosovo Study Group (LN Ahmetaj,* R Baftiu, Y Ahmetaj, M Shahini, G Parduzi, D Ahmetaj, A Kafexholli, D Musliu, A Deva, A Rabushaj, E Blyta, A Breznica, I Jakupi, F Spahiu, University of Prishtina "Hasan Prishtina", Medical Faculty, Kosovo (Prishtina); I Bucaliu-Ismajli, The Principal Center of Family Care (Ferizaj); L Pajaziti, University Hospital Clinic, Clinic of Dermatology, Prishtina, Kosovo (Gjakova); L Hana-Lleshi, General Hospital "Isa Grezda" Gjakova, Kosovo (Gjakova Adults); V Ghashi, Regional Hospital, "Sami Haxhibeqiri" Mitrovica, Kosovo (Gjilan); X Kurhasani, UBT College, Kosovo (Peja); B Gacaferri-Lumezi, University of Prishtina "Hasan Prishtina", Medical Faculty, Kosovo (Peja 6-7); V Zhjeqi, University of Prishtina (Prizren); V Lokaj-Berisha, University of Prishtina (Prizren Adults). LA - eng PT - Journal Article DEP - 20241101 PL - Singapore TA - Allergol Immunopathol (Madr) JT - Allergologia et immunopathologia JID - 0370073 RN - 362O9ITL9D (Acetaminophen) SB - IM MH - Humans MH - *Acetaminophen/adverse effects MH - Male MH - Prevalence MH - Adolescent MH - Female MH - *Dermatitis, Atopic/epidemiology MH - *Exercise MH - Cross-Sectional Studies MH - *Respiratory Sounds MH - Sex Factors MH - Risk Factors MH - Surveys and Questionnaires MH - Child OTO - NOTNLM OT - Kosovo OT - Paracetamol OT - adolescents OT - atopic eczema OT - epidemiology OT - exercise COIS- The authors declared no conflict of interest. EDAT- 2024/11/13 13:51 MHDA- 2024/11/13 13:52 CRDT- 2024/11/08 19:43 PHST- 2024/06/14 00:00 [received] PHST- 2024/09/02 00:00 [accepted] PHST- 2024/11/13 13:52 [medline] PHST- 2024/11/13 13:51 [pubmed] PHST- 2024/11/08 19:43 [entrez] AID - 10.15586/aei.v52i6.1155 [doi] PST - epublish SO - Allergol Immunopathol (Madr). 2024 Nov 1;52(6):40-50. doi: 10.15586/aei.v52i6.1155. eCollection 2024. PMID- 39515747 OWN - NLM STAT- MEDLINE DCOM- 20241213 LR - 20260604 IS - 1879-176X (Electronic) IS - 0300-5712 (Linking) VI - 152 DP - 2025 Jan TI - Quantitative relationship between free sugars intake and early childhood caries among preschoolers in Sri Lanka. PG - 105441 LID - S0300-5712(24)00611-0 [pii] LID - 10.1016/j.jdent.2024.105441 [doi] AB - INTRODUCTION: Before implementing the WHO sugar recommendations, more studies are needed concerning its application to given contexts. OBJECTIVE: To identify free sugars intake levels associated with a minimum caries risk in primary dentition METHODS: Using probability proportionate to size technique and cluster sampling, 813 children aged 4-5-years were selected from preschools in the Colombo district, Sri Lanka. A 67-item quantitative food frequency questionnaire was developed and validated to evaluate free sugars intake. Dental caries was assessed clinically using dmft index. For the selection of cut-off values for free sugars intake levels, ROC curves were used. RESULTS: The median (IQR) amount of free sugars intake was 57.9 (33.2 -95.8) g/day or 21.1 % (12.5 %-35.9 %) of total energy requirement, with a frequency of 4.0 (2.7-6.1) times/day. Dental caries prevalence was 42.9 % (n = 349). Among all possible risk factors, free sugars intake as a percentage of total energy requirement (p < 0.001) and frequency of free sugars intake (p < 0.001) were significantly associated with the presence of dental caries. The percentage of free sugars that discriminates against a possible highest number of children with dental caries (99 %) was determined as 4 %, of the total energy requirement of a child, which is approximately 12 g/day (3 level teaspoons/day). Sugar intake once a day has a 97 % sensitivity in identifying children with dental caries. These cut-off values do not differ among the group who brush twice a day with fluoridated toothpaste. CONCLUSION: For optimal caries prevention, children's free sugar intake should limit to <5 % of their total energy intake or consume less frequently than once daily. CLINICAL SIGNIFICANCE: This study provides facts that policy makers and dental clinicians can use for dietary recommendations in Sri Lanka, which they will include in the next revision of the booklet, "Uniform Oral Health Messages for Sri Lankans". Additionally, health professionals and health information materials will disseminate these recommendations to the public. CI - Copyright (c) 2024 Elsevier Ltd. All rights reserved. FAU - Mututanthri, S A AU - Mututanthri SA AD - Health Promotion Bureau, Ministry of Health, Colombo 10, Sri Lanka. Electronic address: shanikaayanthi1976@gmail.com. FAU - Thoradeniya, T AU - Thoradeniya T AD - Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. FAU - Harris, R AU - Harris R AD - Department of Public Health, Policy and Systems, University of Liverpool, Whelan Building, Quadrangle, Liverpool L69 3GB, United Kingdom. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241106 PL - England TA - J Dent JT - Journal of dentistry JID - 0354422 RN - 0 (Dietary Sugars) SB - IM MH - Humans MH - Sri Lanka/epidemiology MH - *Dental Caries/epidemiology MH - Child, Preschool MH - Female MH - Male MH - *Dietary Sugars MH - Risk Factors MH - *DMF Index MH - Prevalence MH - Tooth, Deciduous MH - Surveys and Questionnaires MH - Energy Intake OTO - NOTNLM OT - Early childhood caries OT - Fluoridated toothpaste OT - Free sugars OT - Oral health OT - Preschool children OT - Risk factors COIS- Declaration of competing interest The authors declare that they have no conflict-of-interests. EDAT- 2024/11/13 13:47 MHDA- 2024/12/14 00:24 CRDT- 2024/11/08 19:29 PHST- 2024/07/10 00:00 [received] PHST- 2024/10/25 00:00 [revised] PHST- 2024/10/28 00:00 [accepted] PHST- 2024/12/14 00:24 [medline] PHST- 2024/11/13 13:47 [pubmed] PHST- 2024/11/08 19:29 [entrez] AID - S0300-5712(24)00611-0 [pii] AID - 10.1016/j.jdent.2024.105441 [doi] PST - ppublish SO - J Dent. 2025 Jan;152:105441. doi: 10.1016/j.jdent.2024.105441. Epub 2024 Nov 6. PMID- 39513191 OWN - NLM STAT- MEDLINE DCOM- 20241211 LR - 20261005 IS - 1497-0015 (Electronic) IS - 0706-7437 (Print) IS - 0706-7437 (Linking) VI - 69 IP - 12 DP - 2024 Dec TI - Physical Activity as a Predictor of Internet Gaming Disorder in a Swiss Male Cohort (C-SURF): L'activite physique comme predicteur des troubles lies aux jeux video en ligne dans une cohorte de jeunes hommes suisses (C-SURF). PG - 855-860 LID - 10.1177/07067437241293979 [doi] AB - HISTORY AND OBJECTIVES: This study addresses the increasing global concerns surrounding Internet gaming disorder (IGD) by exploring their connection to physical activity (PA) as a potential preventive and early intervention measure. The research aims to examine the relationship between PA and the progression of IGD. METHODS: Longitudinal data from the Cohort research on Substance Use Risk Factors involving young Swiss men undergoing army conscription was employed. PA levels were assessed using the International PA Questionnaire (IPAQ), while the Game Addiction Scale (GAS) and Compulsive Internet Use Scale determined IGD presence. Analysis involved zero-inflated negative binomial regression models. RESULTS: Higher PA levels were associated with lower IGD risk. Notably, individuals engaging in high physical exercise exhibited a lower IGD prevalence compared to those with moderate or low activity levels. DISCUSSION: The study suggests that intensive physical exercise might serve as a preventive strategy against developing IGD. This protective effect could stem from various mechanisms. However, the study's limitations, such as a male-only sample and a small low-activity group, should be considered when interpreting results. CONCLUSION: The longitudinal study demonstrates the positive influence of intense physical exercise on mitigating gaming-related issues. These findings underscore the potential of PA interventions in addressing the growing problem of IGDs and their impact on health. Further research is necessary to uncover underlying mechanisms behind the PA-IGD relationship and validate these findings across diverse demographics. FAU - Nowotarski, Adam AU - Nowotarski A AUID- ORCID: 0009-0003-9643-6633 AD - Service d'Addictologie, HUG, Geneve, Switzerland. FAU - Rothen, Stephane AU - Rothen S AD - Service d'Addictologie, HUG, Geneve, Switzerland. FAU - Kasina, Filip AU - Kasina F AD - Service d'Addictologie, HUG, Geneve, Switzerland. FAU - Zullino, Daniele AU - Zullino D AD - Service d'Addictologie, HUG, Geneve, Switzerland. FAU - Thorens, Gabriel AU - Thorens G AUID- ORCID: 0000-0002-3622-9179 AD - Service d'Addictologie, HUG, Geneve, Switzerland. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241108 PL - United States TA - Can J Psychiatry JT - Canadian journal of psychiatry. Revue canadienne de psychiatrie JID - 7904187 SB - IM MH - Humans MH - Male MH - Switzerland MH - *Exercise MH - *Internet Addiction Disorder/epidemiology MH - Young Adult MH - Longitudinal Studies MH - Adult MH - Adolescent MH - Military Personnel/statistics & numerical data PMC - PMC11562881 OTO - NOTNLM OT - Usage problematique d'internet OT - addictions comportementales OT - behavior problems OT - behavioral addictions OT - internet use disorder OT - troubles de comportement COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2024/11/13 14:01 MHDA- 2024/12/11 12:36 PMCR- 2025/05/08 CRDT- 2024/11/08 04:50 PHST- 2024/12/11 12:36 [medline] PHST- 2024/11/13 14:01 [pubmed] PHST- 2024/11/08 04:50 [entrez] PHST- 2025/05/08 00:00 [pmc-release] AID - 10.1177_07067437241293979 [pii] AID - 10.1177/07067437241293979 [doi] PST - ppublish SO - Can J Psychiatry. 2024 Dec;69(12):855-860. doi: 10.1177/07067437241293979. Epub 2024 Nov 8. PMID- 39513065 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241114 IS - 2433-3298 (Electronic) IS - 2433-328X (Print) IS - 2433-328X (Linking) VI - 7 IP - 4 DP - 2024 Oct 15 TI - Possible Efficacy of Vaginal Progesterone on Asymptomatic Women with a Short Cervix after 24 Weeks of Gestation: A Historical Cohort Study in Japan. PG - 582-589 LID - 10.31662/jmaj.2024-0036 [doi] AB - INTRODUCTION: Few studies have explored the preventive efficacy of vaginal progesterone (VD) treatment for preterm delivery (PTD) in Japanese clinical practice. In this study, the efficacy of the VD treatment in pregnant women with a short cervix (sCX) diagnosed after 24 weeks is evaluated, focusing on perinatal outcomes. METHODS: A retrospective historical cohort study. Clinical data of 273 singleton women hospitalized for preventing PTD were extracted. Inclusion criteria are diagnosed sCX at 24-33 weeks. We excluded women with factors including treatment start before 24 weeks, medically induced PTD, PTD on admission day, and fetal demise. Consequently, logistic regression analyses were conducted on data from 79 women during Period 1 (November 2015 to March 2018, using prolonged intravenous ritodrine hydrochloride) and 82 women during Period 2 (August 2018 to August 2022, implementing VD treatment), adjusting maternal age, parity, body mass index, gestational age, cervical length, and histological chorioamnionitis. The primary outcomes involved PTD <37 and <34 weeks and neonatal intensive care unit admission. Secondary outcomes included the interval from the diagnosis of sCX to delivery <14 and <28 days, infant intubation, and surfactant administration. Since VD use is off-label in Japan, we obtained written informed consent prior to treatment. RESULTS: VD treatment (Period 2) significantly decreased the incidence of PTD (birth < 37 weeks) (adjusted odds ratios [ORs] 0.43, 95% confidence intervals [CIs] 0.19-0.96), impending delivery within 14 and 28 days after confirming sCX (adjusted OR 0.12, 95% CI 0.06-0.72; adjusted OR 0.25, 95% CI 0.09-0.74, respectively), and neonatal intubation rate (adjusted OR 0.17, 95% CI 0.04-0.75). CONCLUSIONS: The VD treatment can prevent PTD in asymptomatic women with sCX diagnosed after 24 weeks of gestation. Although further validation is warranted, these findings may contribute to expanding the use of VD treatment in Japanese clinical practice. CI - Copyright (c) Japan Medical Association. FAU - Otsuka, Naoki AU - Otsuka N AD - Division of Obstetrics and Gynecology, Ogaki Municipal Hospital, Gifu, Japan. FAU - Imai, Kenji AU - Imai K AD - Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Tano, Sho AU - Tano S AD - Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Matsuo, Seiko AU - Matsuo S AD - Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Ushida, Takafumi AU - Ushida T AD - Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Nomoto, Masataka AU - Nomoto M AD - Division of Obstetrics and Gynecology, Ogaki Municipal Hospital, Gifu, Japan. FAU - Iitani, Yukako AU - Iitani Y AD - Division of Obstetrics and Gynecology, Ogaki Municipal Hospital, Gifu, Japan. FAU - Ishi, Mika AU - Ishi M AD - Division of Obstetrics and Gynecology, Ogaki Municipal Hospital, Gifu, Japan. FAU - Kawai, Yosuke AU - Kawai Y AD - Division of Obstetrics and Gynecology, Ogaki Municipal Hospital, Gifu, Japan. FAU - Furui, Toshimitsu AU - Furui T AD - Division of Obstetrics and Gynecology, Ogaki Municipal Hospital, Gifu, Japan. FAU - Kajiyama, Hiroaki AU - Kajiyama H AD - Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Kotani, Tomomi AU - Kotani T AD - Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan. LA - eng PT - Journal Article DEP - 20240920 PL - Japan TA - JMA J JT - JMA journal JID - 101769797 PMC - PMC11543341 OTO - NOTNLM OT - Cervical insufficiency OT - Preterm labor OT - Progesterone OT - Short cervix COIS- None EDAT- 2024/11/13 13:56 MHDA- 2024/11/13 13:57 PMCR- 2024/09/20 CRDT- 2024/11/08 04:49 PHST- 2024/03/01 00:00 [received] PHST- 2024/08/09 00:00 [accepted] PHST- 2024/11/13 13:57 [medline] PHST- 2024/11/13 13:56 [pubmed] PHST- 2024/11/08 04:49 [entrez] PHST- 2024/09/20 00:00 [pmc-release] AID - 10.31662/jmaj.2024-0036 [doi] PST - ppublish SO - JMA J. 2024 Oct 15;7(4):582-589. doi: 10.31662/jmaj.2024-0036. Epub 2024 Sep 20. PMID- 39512021 OWN - NLM STAT- MEDLINE DCOM- 20241219 LR - 20241219 IS - 1699-5198 (Electronic) IS - 0212-1611 (Linking) VI - 41 IP - 6 DP - 2024 Dec 19 TI - Adaptation and validation of the Brief Questionnaire for Measuring Disordered Eating Behaviors in Mexican children. PG - 1294-1299 LID - 10.20960/nh.05288 [doi] AB - Introduction: disordered eating behaviors (DEBs) and eating disorders (Eds) mainly occur in adolescence, but they currently already occur at an early age between the ages of five and twelve. Although there are instruments for EDs, it is necessary to have a self-applicable instrument for evaluating DEBs in children. Objective: to determine the reliability and exploratory and confirmatory factorial validity of the Brief Questionnaire for Measuring Disordered Eating Behaviors (BQDEB) in children ages eight to twelve years. Material and methods: the sample comprised 386 Mexican children with an average age of 10.2 years. The BQDEB was adapted for this population, with questions being reduced from ten to seven and answer choices from four to three. Frequency and percentage, reliability, and exploratory and confirmatory validity analyses were undertaken. Results: concern over gaining weight was the most frequent DEB. The exploratory factorial analysis yielded seven items grouped into two factors: 1) compensatory/restrictive behaviors; and 2) binge eating, with a total ordinal alpha reliability of 0.95. Confirmatory factor analysis showed that the model fits the data well. Conclusions: since the psychometric properties of the BQDEB for children were adequate, it constitutes a useful instrument for identifying DEBs in children. FAU - Unikel Santoncini, Claudia AU - Unikel Santoncini C AD - Direccion de Investigaciones Epidemiologicas y Psicosociales. Instituto Nacional de Psiquiatria Ramon de la Fuente Muniz. FAU - Castillo Rangel, Irais AU - Castillo Rangel I AD - Programa Educativo de Licenciatura en Nutricion. Universidad Autonoma de Zacatecas. FAU - Barajas Marquez, Miriam Wendolyn AU - Barajas Marquez MW AD - Universidad Anahuac Mexico, Campus Norte. FAU - Rivera Castaneda, Leticia Adriana AU - Rivera Castaneda LA AD - Red de Especialistas PSICORIV. FAU - Casillas Arias, Ana Berenice AU - Casillas Arias AB AD - Centro de Salud Mental y Trastornos de la Conducta Alimentaria-Annatta. LA - eng PT - Journal Article PT - Validation Study TT - Adaptacion y validacion del Cuestionario Breve para Medir Conductas Alimentarias de Riesgo en ninas y ninos mexicanos. PL - Spain TA - Nutr Hosp JT - Nutricion hospitalaria JID - 9100365 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - Mexico MH - *Feeding and Eating Disorders/diagnosis/epidemiology MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - *Psychometrics MH - Feeding Behavior/psychology MH - Factor Analysis, Statistical OTO - NOTNLM OT - Ninas. Ninos. Conductas alimentarias de riesgo. Medicion. Validez. Confiabilidad. EDAT- 2024/11/13 13:56 MHDA- 2024/12/19 06:22 CRDT- 2024/11/08 03:03 PHST- 2024/12/19 06:22 [medline] PHST- 2024/11/13 13:56 [pubmed] PHST- 2024/11/08 03:03 [entrez] AID - 10.20960/nh.05288 [doi] PST - ppublish SO - Nutr Hosp. 2024 Dec 19;41(6):1294-1299. doi: 10.20960/nh.05288. PMID- 39510723 OWN - NLM STAT- MEDLINE DCOM- 20241107 LR - 20260428 IS - 1938-3207 (Electronic) IS - 0002-9165 (Linking) VI - 120 IP - 5 DP - 2024 Nov TI - Computer vision-assisted dietary assessment through mobile phones in female youth in urban Ghana: validity against weighed records and comparison with 24-h recalls. PG - 1105-1113 LID - S0002-9165(24)00670-1 [pii] LID - 10.1016/j.ajcnut.2024.08.011 [doi] AB - BACKGROUND: Gaps persist in the data on diets and on the validity of dietary assessment methods in youth in low-income and middle-income countries (LMICs) due to costs constraints. Although computer vision-assisted dietary assessment tools have been proposed, limited evidence exists on their validity in LMICs. OBJECTIVES: This study aimed to validate FRANI (Food Recognition Assistance and Nudging Insights), a mobile phone application with computer vision-assisted dietary assessment, against weighed records (WRs) and compare with 24-h recalls (24HR), in female youth in Ghana. METHODS: Dietary intake was assessed on 2 nonconsecutive days using FRANI, WR, and 24HR in females aged 18-24 y recruited at the University of Ghana, Accra (n = 64). Equivalence was examined by comparing intake mean ratios (FRANI/WR and 24HR/WR) with error margins of 10%, 15%, and 20%, using mixed-effect regression models adjusting for repeated measures. Agreement between methods was assessed using the concordance correlation coefficient (CCC). RESULTS: Equivalence for FRANI and WR was found at 10% bound for riboflavin and vitamin B-6 intakes and at 15% bound for protein, fat, calcium, folate, iron, thiamine, vitamin C, and zinc intakes. Energy, fiber, vitamin A, and niacin intakes were equivalent at 20% bound. Comparisons between 24HR and WR found no estimates within a 10% bound. Protein, iron, niacin, riboflavin, and zinc intakes were equivalent at a 15% bound; folate, thiamine, and vitamin B-12 intakes were equivalent at a 20% bound. CCCs between FRANI and WR ranged from 0.45 to 0.74 (mean: 0.60) and between 24HR and WR ranged from 0.48 to 0.76 (mean: 0.63). Omission errors were 15% for FRANI and 22% for 24HR. Intrusion errors were 22% for FRANI and 18% for 24HR. CONCLUSIONS: FRANI-assisted dietary assessment accurately estimates nutrient intake and performed as accurately as 24HR in female youth in Ghana. Although improvements in computer vision-assisted diet assessment are possible, emerging evidence on FRANI suggests its readiness for scale-up. CI - Copyright (c) 2024 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Gelli, Aulo AU - Gelli A AD - International Food Policy Research Institute, Washington, DC, United States. FAU - Nwabuikwu, Odiche AU - Nwabuikwu O AD - International Food Policy Research Institute, Washington, DC, United States. FAU - Bannerman, Boateng AU - Bannerman B AD - Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana. FAU - Ador, Gabriel AU - Ador G AD - Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana. FAU - Atadze, Vicentia AU - Atadze V AD - Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana. FAU - Asante, Millicent AU - Asante M AD - Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana. FAU - Bempong, Silas AU - Bempong S AD - Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana. FAU - McCloskey, Peter AU - McCloskey P AD - PlantVillage, Penn State University, University Park, PA, United States. FAU - Nguyen, Phuong Hong AU - Nguyen PH AD - International Food Policy Research Institute, Washington, DC, United States; Thai Nguyen University of Pharmacy and Medicine, Thai Nguyen, Vietnam. FAU - Hughes, David AU - Hughes D AD - PlantVillage, Penn State University, University Park, PA, United States. FAU - Folson, Gloria AU - Folson G AD - Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana. Electronic address: gfolson@noguchi.ug.edu.gh. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20241008 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Humans MH - Female MH - Ghana MH - Adolescent MH - Young Adult MH - *Nutrition Assessment MH - *Diet Records MH - *Cell Phone MH - *Diet MH - Mental Recall MH - Reproducibility of Results MH - Urban Population MH - Diet Surveys OTO - NOTNLM OT - adolescence OT - diet OT - dietary assessment OT - low-income countries OT - urbanization OT - validation OT - youth EDAT- 2024/11/13 13:59 MHDA- 2024/11/14 03:58 CRDT- 2024/11/07 20:59 PHST- 2024/03/23 00:00 [received] PHST- 2024/07/11 00:00 [revised] PHST- 2024/08/12 00:00 [accepted] PHST- 2024/11/14 03:58 [medline] PHST- 2024/11/13 13:59 [pubmed] PHST- 2024/11/07 20:59 [entrez] AID - S0002-9165(24)00670-1 [pii] AID - 10.1016/j.ajcnut.2024.08.011 [doi] PST - ppublish SO - Am J Clin Nutr. 2024 Nov;120(5):1105-1113. doi: 10.1016/j.ajcnut.2024.08.011. Epub 2024 Oct 8. PMID- 39510722 OWN - NLM STAT- MEDLINE DCOM- 20241107 LR - 20260428 IS - 1938-3207 (Electronic) IS - 0002-9165 (Linking) VI - 120 IP - 5 DP - 2024 Nov TI - Cross-context equivalence and agreement of healthy diet metrics for national and global monitoring: a multicountry analysis of cross-sectional quantitative 24-hour dietary intake studies. PG - 1093-1104 LID - S0002-9165(24)00606-3 [pii] LID - 10.1016/j.ajcnut.2024.07.010 [doi] AB - BACKGROUND: Despite national and global commitments to improve nutrition, there are no universally accepted indicators for at-scale monitoring of diets. Several metrics have been proposed and used, but they vary in their comprehensiveness and validity in capturing the properties of healthy diets and, potentially, their interpretability across contexts. OBJECTIVE: The objective of this study was to assess the cross-context equivalence and agreement of healthy diet metrics. DESIGN: Quantitative 24-h dietary intake data from 57,456 nonpregnant females (15-49 y) in 21 countries were used to construct the food group diversity score (FGDS) and Minimum Dietary Diversity for Women indicator; the Global Diet Quality Score (GDQS) and its submetrics: GDQS+ and GDQS-; the Global Dietary Recommendations (GDR) score and its submetrics: noncommunicable disease (NCD)-Protect and NCD-Risk scores; and the All-5 indicator. Associations between (standardized) measures and indicators were quantified by fitting linear and logistic mixed-effect models across World Bank country income classifications, respectively. The levels of agreement between measures were assessed using Bland-Altman plots of z-scores, whereas rank correlations were assessed using Spearman's rho. RESULTS: The consumption of healthy food groups was positively associated with concurrent intakes of unhealthy food groups, in particular in high-income countries. Hence, metrics constructed using both healthy and unhealthy food groups (i.e., GDR score and GDQS) showed relatively less discriminatory capacity across country income classifications than their respective submetrics or FGDS. Standardized metrics of healthy (e.g., FGDS and GDQS+) and unhealthy food group consumption (i.e., NCD-Risk and GDQS-) exhibited strong agreement and correlations. CONCLUSION: Composite metrics weighting both healthy and unhealthy food groups have limited cross-context equivalence, because a wide range of diets can theoretically return similar scores. Healthy food group (sub)metrics performed comparably, likely indicating strong underlying construct validity (i.e., dietary diversity and nutrient adequacy). For national and global monitoring, refinement and validation of unhealthy food group metrics (i.e., moderation) is recommended to complement healthy food group metrics. CI - Copyright (c) 2024 Food and Agriculture Organization of the United Nations. Published by Elsevier Inc. All rights reserved. FAU - Hanley-Cook, Giles T AU - Hanley-Cook GT AD - Food and Nutrition Division (ESN), Food and Agriculture Organization of the United Nations (FAO), Rome, Italy. Electronic address: giles.hanleycook@fao.org. FAU - Gie, Simone M AU - Gie SM AD - Food and Nutrition Division (ESN), Food and Agriculture Organization of the United Nations (FAO), Rome, Italy. FAU - Parraguez, Juan Pablo AU - Parraguez JP AD - Food and Nutrition Division (ESN), Food and Agriculture Organization of the United Nations (FAO), Rome, Italy. FAU - Hoogerwerf, Sara AU - Hoogerwerf S AD - Food and Nutrition Division (ESN), Food and Agriculture Organization of the United Nations (FAO), Rome, Italy. FAU - Padula de Quadros, Victoria AU - Padula de Quadros V AD - Food and Nutrition Division (ESN), Food and Agriculture Organization of the United Nations (FAO), Rome, Italy. FAU - Balcerzak, Agnieszka AU - Balcerzak A AD - Food and Nutrition Division (ESN), Food and Agriculture Organization of the United Nations (FAO), Rome, Italy. FAU - Neufeld, Lynnette M AU - Neufeld LM AD - Food and Nutrition Division (ESN), Food and Agriculture Organization of the United Nations (FAO), Rome, Italy. FAU - Holmes, Bridget A AU - Holmes BA AD - Food and Nutrition Division (ESN), Food and Agriculture Organization of the United Nations (FAO), Rome, Italy. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241003 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Humans MH - Female MH - Adult MH - *Diet, Healthy/statistics & numerical data MH - Cross-Sectional Studies MH - Middle Aged MH - Adolescent MH - Young Adult MH - Global Health MH - Diet Surveys/standards MH - Diet OTO - NOTNLM OT - 24-h recall OT - FAO/WHO GIFT OT - dietary diversity OT - food diary OT - moderation OT - nutrient adequacy EDAT- 2024/11/13 13:51 MHDA- 2024/11/14 03:58 CRDT- 2024/11/07 20:59 PHST- 2023/12/29 00:00 [received] PHST- 2024/07/09 00:00 [revised] PHST- 2024/07/11 00:00 [accepted] PHST- 2024/11/14 03:58 [medline] PHST- 2024/11/13 13:51 [pubmed] PHST- 2024/11/07 20:59 [entrez] AID - S0002-9165(24)00606-3 [pii] AID - 10.1016/j.ajcnut.2024.07.010 [doi] PST - ppublish SO - Am J Clin Nutr. 2024 Nov;120(5):1093-1104. doi: 10.1016/j.ajcnut.2024.07.010. Epub 2024 Oct 3. PMID- 39510447 OWN - NLM STAT- MEDLINE DCOM- 20241130 LR - 20260531 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 204 DP - 2025 Jan 1 TI - Effectiveness of the Eco-score food label: An information experiment combined with Nutri-score label in Belgium. PG - 107759 LID - S0195-6663(24)00563-4 [pii] LID - 10.1016/j.appet.2024.107759 [doi] AB - Consumers' food choices significantly impact the environment, with food production contributing substantially to global greenhouse gas emissions and water use. In response, policy interventions such as front-of-pack eco-labels aim to guide consumers towards more environmentally friendly food choices. The recently introduced Eco-score aims to guide consumers toward environmentally friendlier food choices. However, evidence regarding its effectiveness, particularly when used alongside the Nutri-score, remains limited. A cross-sectional online survey was conducted with 607 Belgian respondents. Respondents assessed their perceived environmental impact of food products with various Eco-score and Nutri-score combinations. They were randomly assigned to one of two conditions, where one group saw both labels, while the other saw none when assessing the food products. Generalized linear models were used to determine if the Eco-score improved accuracy in assessing the environmental impact of food products, and a structural equation model analysed factors influencing the intention to use the Eco-score. Results show that the Eco-score enhances accuracy in environmental impact assessment, particularly when respondents are knowledgeable about the Eco-score and indicate environmental concerns. However, effects were less pronounced for products with conflicting Eco- and Nutri-scores, potentially due to cognitive dissonance. Furthermore, factors such as knowledge about and positive perceptions towards the Eco-score significantly influenced the intention to use it. The Eco-score's potential as a tool to guide consumers towards more environmentally friendly food choices is validated by their positive perception and enhanced evaluative capacity among a representative sample of the Belgian population. Further research and a broader implementation are necessary to assess the long-term impact and utility of the Eco-score in promoting sustainable food consumption. CI - Copyright (c) 2024 Elsevier Ltd. All rights reserved. FAU - Berden, Jeroen AU - Berden J AD - Department of Agricultural Economics, Faculty of Bioscience Engineering, Ghent University, B-9000, Ghent, Belgium; Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, B- 9000, Ghent, Belgium. FAU - Hung, Yung AU - Hung Y AD - Department of Agricultural Economics, Faculty of Bioscience Engineering, Ghent University, B-9000, Ghent, Belgium. Electronic address: yung.hung@ugent.be. LA - eng PT - Journal Article DEP - 20241105 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Belgium MH - Female MH - Male MH - Adult MH - *Food Labeling/methods MH - Cross-Sectional Studies MH - *Food Preferences/psychology MH - Middle Aged MH - *Consumer Behavior MH - *Choice Behavior MH - Young Adult MH - Nutritive Value MH - Surveys and Questionnaires MH - Adolescent MH - Environment MH - Health Knowledge, Attitudes, Practice MH - Aged OTO - NOTNLM OT - Colour-coded front-of-pack (FOP) label OT - Consumer behavior (behaviour) OT - Marketing tool OT - Nudging OT - Policy intervention OT - Structured equation modelling OT - Sustainable production and food choice COIS- Declaration of competing interest This is a self-funded study and the authors declare no conflict of interest. EDAT- 2024/11/13 13:58 MHDA- 2024/12/01 15:22 CRDT- 2024/11/07 19:43 PHST- 2024/07/11 00:00 [received] PHST- 2024/10/21 00:00 [revised] PHST- 2024/11/04 00:00 [accepted] PHST- 2024/12/01 15:22 [medline] PHST- 2024/11/13 13:58 [pubmed] PHST- 2024/11/07 19:43 [entrez] AID - S0195-6663(24)00563-4 [pii] AID - 10.1016/j.appet.2024.107759 [doi] PST - ppublish SO - Appetite. 2025 Jan 1;204:107759. doi: 10.1016/j.appet.2024.107759. Epub 2024 Nov 5. PMID- 39510331 OWN - NLM STAT- MEDLINE DCOM- 20250425 LR - 20260608 IS - 1549-4713 (Electronic) IS - 0161-6420 (Print) IS - 0161-6420 (Linking) VI - 132 IP - 4 DP - 2025 Apr TI - Nationwide Prevalence and Geographic Variation of Idiopathic Intracranial Hypertension among Women in the United States. PG - 476-483 LID - S0161-6420(24)00686-9 [pii] LID - 10.1016/j.ophtha.2024.10.031 [doi] AB - PURPOSE: To determine the nationwide prevalence and geographic distribution of idiopathic intracranial hypertension (IIH) among women in the United States. DESIGN: Retrospective cross-sectional study using Medicaid claims and electronic health record data from the IRIS(R) Registry (Intelligent Research in Sight) and Sight Outcomes Research Collaborative (SOURCE). PARTICIPANTS: Female Medicaid beneficiaries 18 to 55 years of age with IIH diagnoses and prescriptions for acetazolamide or methazolamide in 2018 were identified, excluding those with other causes of intracranial hypertension. We calculated the proportion of women with IIH in the United States who were insured by Medicaid by combining analyses from the IRIS Registry and SOURCE. METHODS: To calculate the number of women with IIH in each state, we divided the number of Medicaid beneficiaries by the proportion of patients insured by Medicaid. We used census data from the 2018 American Community Survey to calculate prevalence. MAIN OUTCOME MEASURES: We examined geographic variation in IIH prevalence using Moran's I statistic and compared it to obesity prevalence data from the 2018 Behavioral Risk Factor Surveillance System. In a validation study, we compared the calculated prevalence of IIH in Minnesota with similar data from the Rochester Epidemiology Project. RESULTS: Of 13 959 female Medicaid beneficiaries with IIH, 6828 had a prescription for acetazolamide or methazolamide. In the IRIS Registry and SOURCE, 25% of women with IIH were insured by Medicaid (95% confidence interval [CI], 16%-33%), suggesting that 27 312 women 18 to 55 years of age with IIH were taking acetazolamide or methazolamide in 2018 (6828 / 0.25 = 27 312). Prevalence was 3.44 per 10 000 women (95% CI, 2.61-5.39 per 10 000 women), and significant geographic variation was found (Moran I statistic, 0.20; P = 0.03), with higher prevalence in states where obesity was more common. The calculated prevalence of IIH in Minnesota was statistically equivalent to that identified using Rochester Epidemiology Project data (P < 0.05 for equivalence test). CONCLUSIONS: Idiopathic intracranial hypertension affects 3.44 per 10 000 women 18 to 55 years of age in the United States with significant geographic variation, some of which is explained by variation in obesity prevalence. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. CI - Copyright (c) 2024 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved. FAU - Fraz, Muhammad A AU - Fraz MA AD - Departments of Neurology and Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. FAU - Kim, B Michelle AU - Kim BM AD - Mayo Clinic School of Medicine, Rochester, Minnesota. FAU - Chen, John J AU - Chen JJ AD - Departments of Neurology and Ophthalmology, Mayo Clinic, Rochester, Minnesota. FAU - Lum, Flora AU - Lum F AD - American Academy of Ophthalmology, San Francisco, California. FAU - Chen, Jinbo AU - Chen J AD - Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. FAU - Liu, Grant T AU - Liu GT AD - Departments of Neurology and Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. FAU - Hamedani, Ali G AU - Hamedani AG AD - Departments of Neurology and Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: Ali.hamedani@pennmedicine.upenn.edu. CN - SOURCE Consortium LA - eng GR - K23 EY033438/EY/NEI NIH HHS/United States PT - Journal Article PT - Multicenter Study PT - Research Support, N.I.H., Extramural DEP - 20241106 PL - United States TA - Ophthalmology JT - Ophthalmology JID - 7802443 RN - O3FX965V0I (Acetazolamide) SB - IM MH - Humans MH - Female MH - Adult MH - Prevalence MH - United States/epidemiology MH - Middle Aged MH - Cross-Sectional Studies MH - *Pseudotumor Cerebri/epidemiology/drug therapy MH - Retrospective Studies MH - Young Adult MH - Adolescent MH - Medicaid/statistics & numerical data MH - Registries MH - Acetazolamide/therapeutic use PMC - PMC11930622 MID - NIHMS2034123 OTO - NOTNLM OT - IRIS(R) Registry OT - Idiopathic intracranial hypertension OT - Medicaid OT - Prevalence OT - Spatial epidemiology COIS- Conflicts of interest: No conflicting relationship exists for any author. FIR - Amin, Sejal IR - Amin S IRAD- Henry Ford Health System. FIR - Edwards, Paul A IR - Edwards PA IRAD- Henry Ford Health System. FIR - Srikumaran, Divya IR - Srikumaran D IRAD- Johns Hopkins University. FIR - Woreta, Fasika IR - Woreta F IRAD- Johns Hopkins University. FIR - Schultz, Jeffrey S IR - Schultz JS IRAD- Montefiore Medical Center. FIR - Shrivastava, Anurag IR - Shrivastava A IRAD- Montefiore Medical Center. FIR - Ahmad, Baseer IR - Ahmad B IRAD- Medical College of Wisconsin. FIR - Bryar, Paul IR - Bryar P IRAD- Northwestern University. FIR - French, Dustin IR - French D IRAD- Northwestern University. FIR - Vanderbeek, Brian L IR - Vanderbeek BL IRAD- Scheie Eye Institute. FIR - Pershing, Suzann IR - Pershing S IRAD- Stanford University. FIR - Wang, Sophia Y IR - Wang SY IRAD- Stanford University. FIR - Lynch, Anne M IR - Lynch AM IRAD- University of Colorado. FIR - Patnaik, Jenna IR - Patnaik J IRAD- University of Colorado. FIR - Munir, Saleha IR - Munir S IRAD- University of Maryland. FIR - Munir, Wuqaas IR - Munir W IRAD- University of Maryland. FIR - Stein, Joshua IR - Stein J IRAD- University of Michigan. FIR - DeLott, Lindsey IR - DeLott L IRAD- University of Michigan. FIR - Stagg, Brian C IR - Stagg BC IRAD- University of Utah. FIR - Wirostko, Barbara IR - Wirostko B IRAD- University of Utah. FIR - McMillian, Brian IR - McMillian B IRAD- University of West Virginia. FIR - Sheybani, Arsham IR - Sheybani A IRAD- Washington University. FIR - Sarrapour, Soshian IR - Sarrapour S IRAD- Yale University. FIR - Nwanyanwu, Kristen IR - Nwanyanwu K IRAD- Yale University. FIR - Deiner, Michael IR - Deiner M IRAD- University of California, San Francisco. FIR - Sun, Catherine IR - Sun C IRAD- University of California, San Francisco. FIR - Feldman, Robert IR - Feldman R IRAD- University of Texas - Houston. FIR - Ramachandran, Rajeev IR - Ramachandran R IRAD- University of Rochester. EDAT- 2024/11/13 13:53 MHDA- 2025/03/23 16:51 PMCR- 2026/04/01 CRDT- 2024/11/07 19:41 PHST- 2024/07/29 00:00 [received] PHST- 2024/10/21 00:00 [revised] PHST- 2024/10/24 00:00 [accepted] PHST- 2025/03/23 16:51 [medline] PHST- 2024/11/13 13:53 [pubmed] PHST- 2024/11/07 19:41 [entrez] PHST- 2026/04/01 00:00 [pmc-release] AID - S0161-6420(24)00686-9 [pii] AID - 10.1016/j.ophtha.2024.10.031 [doi] PST - ppublish SO - Ophthalmology. 2025 Apr;132(4):476-483. doi: 10.1016/j.ophtha.2024.10.031. Epub 2024 Nov 6. PMID- 39509932 OWN - NLM STAT- MEDLINE DCOM- 20241212 LR - 20260522 IS - 1879-0739 (Electronic) IS - 0271-5317 (Linking) VI - 132 DP - 2024 Dec TI - Dietary Inflammatory Index is associated with periodontitis risk in pregnant women with gestational diabetes mellitus. PG - 85-94 LID - S0271-5317(24)00135-0 [pii] LID - 10.1016/j.nutres.2024.10.001 [doi] AB - Recent studies suggest a link between periodontitis and the Dietary Inflammatory Index (DII). We hypothesize that a more proinflammatory diet is associated with periodontitis risk in pregnant women with gestational diabetes mellitus (GDM). This study aimed to explore the association between DII scores and periodontitis risk in GDM women. In this cross-sectional study, 302 eligible GDM women from a Maternal and Child Health Hospital were enrolled between February and July 2023. DII scores were calculated based on dietary intake data collected using a validated semiquantitative food frequency questionnaire. Periodontal health was assessed through periodontal parameters including bleeding on probing, probing depth, and clinical attachment loss. Logistic regression models were employed to evaluate the odds ratios (ORs) for periodontitis risk across DII tertiles. Our study found that the prevalence of periodontitis across the DII tertiles 1, 2, and 3 was 34.7%, 56.4%, and 54.0%, respectively. Comparing the highest DII tertile (tertile 3) with the lowest (tertile 1), a significant association was found between higher DII scores and periodontitis risk (univariate OR: 2.21; 95% CI: 1.25, 3.90; P = .006), which remained significant in the fully adjusted model (adjusted OR: 2.30; 95% CI: 1.21, 4.37; P = .011). In conclusion, elevated DII scores are associated with an increased risk of periodontitis, underscoring the crucial role of a proinflammatory diet in periodontitis progression. Future well-designed experimental studies are needed to verify if tailored dietary strategies can effectively reduce periodontitis risk among pregnant women with GDM. CI - Copyright (c) 2024 Elsevier Inc. All rights reserved. FAU - Liu, Ru-Lin AU - Liu RL AD - School of Nursing, Fujian Medical University, Fuzhou, Fujian, China; Department of Nursing, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China. FAU - Chen, Xiao-Qian AU - Chen XQ AD - Department of Nursing, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China; Department of Nursing, Fujian Obstetrics and Gynecology Hospital, Fuzhou, Fujian, China. FAU - Liu, Jing AU - Liu J AD - Department of Stomatology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China. FAU - Zheng, Qing-Xiang AU - Zheng QX AD - Department of Nursing, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China; Department of Nursing, Fujian Obstetrics and Gynecology Hospital, Fuzhou, Fujian, China. FAU - Jiang, Xiu-Min AU - Jiang XM AD - Department of Nursing, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China. Electronic address: jzc0427@163.com. FAU - Li, Jia-Ning AU - Li JN AD - School of Nursing, Fujian Medical University, Fuzhou, Fujian, China. FAU - Huang, Ling AU - Huang L AD - School of Nursing, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China. FAU - Zhu, Yu AU - Zhu Y AD - School of Nursing, Fujian Medical University, Fuzhou, Fujian, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241010 PL - United States TA - Nutr Res JT - Nutrition research (New York, N.Y.) JID - 8303331 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Diabetes, Gestational MH - *Periodontitis/complications/epidemiology MH - Adult MH - Cross-Sectional Studies MH - *Diet MH - *Inflammation MH - Risk Factors MH - Prevalence OTO - NOTNLM OT - Diabetes, Gestational OT - Diet OT - Inflammation OT - Periodontitis OT - Pregnancy COIS- Author Declarations The authors declare no conflict of interest. EDAT- 2024/11/13 13:49 MHDA- 2024/12/13 00:23 CRDT- 2024/11/07 18:07 PHST- 2024/03/29 00:00 [received] PHST- 2024/10/04 00:00 [revised] PHST- 2024/10/04 00:00 [accepted] PHST- 2024/12/13 00:23 [medline] PHST- 2024/11/13 13:49 [pubmed] PHST- 2024/11/07 18:07 [entrez] AID - S0271-5317(24)00135-0 [pii] AID - 10.1016/j.nutres.2024.10.001 [doi] PST - ppublish SO - Nutr Res. 2024 Dec;132:85-94. doi: 10.1016/j.nutres.2024.10.001. Epub 2024 Oct 10. PMID- 39509928 OWN - NLM STAT- MEDLINE DCOM- 20241124 LR - 20260708 IS - 1872-6232 (Electronic) IS - 0378-3782 (Linking) VI - 199 DP - 2024 Dec TI - Diet, growth, nutritional status and predictors of severity of feeding difficulties in autistic children with co-occurring pediatric feeding disorder. PG - 106137 LID - S0378-3782(24)00206-8 [pii] LID - 10.1016/j.earlhumdev.2024.106137 [doi] AB - BACKGROUND: Feeding difficulties are commonly reported in autistic children. However, there is limited data on the presentation, severity, and impact of feeding difficulties in autistic children in Asia. AIMS: To describe the dietary patterns, growth and nutritional status of autistic children with pediatric feeding disorder (PFD), and identify factors associated with more severe feeding difficulties. STUDY DESIGN: A retrospective review of electronic medical records. SUBJECTS: Autistic children (aged between 0 and 18 years) with PFD, who attended a multidisciplinary feeding clinic between August 2013 and December 2022. OUTCOME MEASURES: The children's parents provided a 3-day food diary, which was verified by the dietitian and analyzed for their nutritional content using Foodworks 10 Professional. Food selectivity was classified as mild, moderate or severe, based on the number of food groups accepted and the absolute number of foods accepted in each group. Information regarding demographics, height, weight, medical information, developmental history (autism diagnosis, cognition, adaptive skills) and relevant nutritional bloodwork were collected. Parents also completed two validated questionnaires (the Behavioral Pediatrics Feeding Assessment Scale (BPFAS), which assessed childhood mealtime behaviors; and the Caregiver Feeding Style Questionnaire (CFSQ), which determined caregiver/ parental feeding styles). Factors associated with higher BPFAS total frequency scores (TFS) (representing more severe feeding difficulties) and food selectivity were analyzed. RESULTS: There were a total of 98 patients (82 males), with mean +/- SD (range) age of 59.2 +/- 27.5 (17-169) months. They had mild (19.4 %), moderate (22.4 %) and severe (58.2 %) food selectivity, respectively. While the majority had normal weight (84.7 %) and height (88.8 %) for age, 69.4 % had diets deficient in calories, macronutrients or micronutrients (iron, calcium). Comparison between groups according to parental feeding style found that there was a significant difference in BFPAS TFS between different parental feeding styles (p < 0.001). Post-hoc testing revealed that parents who reported an authoritarian parental feeding style on the CFSQ were significantly more likely to report higher frequencies of difficult feeding behaviors on the BPFAS (98.3 +/- 15.8), while an uninvolved parental feeding style was associated with the lowest BPFAS TFS (80.9 +/- 11.0), Bonferroni-adjusted p < 0.001; indulgent (p = 0.012) and authoritative (p = 0.096). Intellectual impairment and Malay ethnicity were associated with more severe food selectivity [adjusted odds ratio 123.7 (95 % CI 3.09-4945.4, p = 0.01) and 38.0 (95 % CI 1.35-1074.18, p = 0.03)], respectively. CONCLUSIONS: In this retrospective cohort, autistic children with PFD were at significant nutritional risk despite demonstrating normal growth patterns, with specific patient profiles being associated with more severe feeding difficulties. CI - Copyright (c) 2024 Elsevier B.V. All rights reserved. FAU - Lim, Tammy S H AU - Lim TSH AD - Child Development Unit, Khoo Teck Puat - National University Children's Medical Institute, National University Hospital, National University Health System, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Paediatric Gastroenterology, Nutrition, Hepatology and Liver Transplantation, Khoo Teck Puat - National University Children's Medical Institute, National University Hospital, National University Health System, Singapore. FAU - Wong, Chui Ying AU - Wong CY AD - Department of Dietetics, National University Hospital, Singapore. FAU - Lin, Charlotte AU - Lin C AD - Department of Dietetics, National University Hospital, Singapore. FAU - Phua, Quan Quan AU - Phua QQ AD - Department of Rehabilitation, National University Hospital, Singapore. FAU - Tok, Ada E S AU - Tok AES AD - Department of Rehabilitation, National University Hospital, Singapore. FAU - Cheng, Alison S M AU - Cheng ASM AD - Child Development Unit, Khoo Teck Puat - National University Children's Medical Institute, National University Hospital, National University Health System, Singapore. FAU - Chan, Yiong Huak AU - Chan YH AD - Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. FAU - Aw, Marion M AU - Aw MM AD - Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Paediatric Gastroenterology, Nutrition, Hepatology and Liver Transplantation, Khoo Teck Puat - National University Children's Medical Institute, National University Hospital, National University Health System, Singapore. LA - eng PT - Journal Article DEP - 20241101 PL - Ireland TA - Early Hum Dev JT - Early human development JID - 7708381 SB - IM MH - Humans MH - Male MH - Female MH - Child MH - Child, Preschool MH - *Nutritional Status MH - Infant MH - Adolescent MH - *Autistic Disorder/epidemiology MH - Feeding Behavior MH - Diet MH - Feeding and Eating Disorders of Childhood/epidemiology/etiology MH - Retrospective Studies OTO - NOTNLM OT - Autism spectrum disorder OT - Feeding difficulties OT - Growth OT - Nutrition OT - Pediatric feeding disorder COIS- Declaration of competing interest The authors report no conflicts of interest. EDAT- 2024/11/13 13:51 MHDA- 2024/11/25 01:26 CRDT- 2024/11/07 18:07 PHST- 2024/04/30 00:00 [received] PHST- 2024/10/07 00:00 [revised] PHST- 2024/10/29 00:00 [accepted] PHST- 2024/11/25 01:26 [medline] PHST- 2024/11/13 13:51 [pubmed] PHST- 2024/11/07 18:07 [entrez] AID - S0378-3782(24)00206-8 [pii] AID - 10.1016/j.earlhumdev.2024.106137 [doi] PST - ppublish SO - Early Hum Dev. 2024 Dec;199:106137. doi: 10.1016/j.earlhumdev.2024.106137. Epub 2024 Nov 1. PMID- 39506981 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241108 IS - 2352-8273 (Print) IS - 2352-8273 (Electronic) IS - 2352-8273 (Linking) VI - 28 DP - 2024 Dec TI - Association between snack intake behaviors of children and neighboring women: A population-based cross-sectional analysis with spatial regionalization. PG - 101720 LID - 10.1016/j.ssmph.2024.101720 [doi] LID - 101720 AB - BACKGROUND: Accumulated evidence indicates that neighborhood environments affect children's health behaviors. However, measuring neighborhood environments remains challenging because there exist strengths and weaknesses both in objective and perceived environment measures. Drawing on a recent conceptual model of how environment, perception, and behavior interact, we hypothesized that neighbors' behavioral similarities indicate the combined influence of physical and social environmental opportunities on specific behaviors. We then examined how these similarities (i.e. the behavioral tendencies of children's adult neighbors) relate to children's obesogenic dietary behaviors. METHODS: We used data for 2275 women and 821 elementary schoolchildren from a 2012-2013 population-based survey in greater Tokyo, Japan. Snack intake was defined as the total consumption of various types of snacks, estimated using a validated self-administered diet history questionnaire. Spatial regionalization, a type of spatial clustering, was used to empirically identify segments that could effectively differentiate regional variation in women's snack intake behaviors. We conducted multiple regression analysis to assess the cross-sectional association between children's snack intake and the mean snack intake of neighborhood women, adjusting for mother's intake. RESULTS: A 1-g increase in the mean snack intake of neighborhood women was associated with a 0.23-g (95% confidence interval: 0.00-0.45) increase in children's intake, while a 1-g increase in mother's intake was associated with a 0.34-g (95% confidence interval: 0.26-0.41) increase in children's intake. DISCUSSION: The results suggest that the out-of-home physical and social neighborhood environments may have non-ignorable associations with children's dietary behaviors by offering behavioral opportunities in addition to maternal influence. CI - (c) 2024 The Authors. FAU - Yamamoto, Emiko AU - Yamamoto E AD - Department of Health and Social Behavior, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. FAU - Takagi, Daisuke AU - Takagi D AD - Department of Health and Social Behavior, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. FAU - Hashimoto, Hideki AU - Hashimoto H AD - Department of Health and Social Behavior, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. LA - eng PT - Journal Article DEP - 20241013 PL - England TA - SSM Popul Health JT - SSM - population health JID - 101678841 PMC - PMC11539136 OTO - NOTNLM OT - Dietary behavior OT - Elementary schoolchildren OT - Neighborhood environment OT - Snack intake OT - Social learning OT - Spatial regionalization COIS- The authors have nothing to declare. EDAT- 2024/11/12 04:45 MHDA- 2024/11/12 04:46 PMCR- 2024/10/13 CRDT- 2024/11/07 04:25 PHST- 2024/08/21 00:00 [received] PHST- 2024/10/10 00:00 [revised] PHST- 2024/10/12 00:00 [accepted] PHST- 2024/11/12 04:46 [medline] PHST- 2024/11/12 04:45 [pubmed] PHST- 2024/11/07 04:25 [entrez] PHST- 2024/10/13 00:00 [pmc-release] AID - S2352-8273(24)00121-6 [pii] AID - 101720 [pii] AID - 10.1016/j.ssmph.2024.101720 [doi] PST - epublish SO - SSM Popul Health. 2024 Oct 13;28:101720. doi: 10.1016/j.ssmph.2024.101720. eCollection 2024 Dec. PMID- 39504249 OWN - NLM STAT- MEDLINE DCOM- 20250624 LR - 20260621 IS - 1464-0600 (Electronic) IS - 0269-9931 (Linking) VI - 39 IP - 4 DP - 2025 Jun TI - The dual-feature approach-avoidance task: validity, training efficacy, and the role of contingency awareness in changing food preference. PG - 876-898 LID - 10.1080/02699931.2024.2418445 [doi] AB - The approach-avoidance task (AAT) probes tendencies contributing to unwanted behaviours, like excessive snacking, by measuring RT differences between approach and avoidance responses to different stimuli. It retrains such tendencies using repeated avoidance of appetitive stimuli and approach of healthy alternatives. The most common paradigm, the irrelevant-feature AAT, conceals these stimulus-response contingencies by requiring approach or avoidance based on features irrelevant to the tendencies (e.g. frame colour). Unfortunately, it is an unreliable measure and not always successful as a training, likely because the stimuli can be ignored. In the novel dual-feature AAT, the combination of stimulus and irrelevant feature determines responses: participants approach foods and avoid objects surrounded by frame A, and vice versa given frame B. We trained 219 online participants to approach fruit and avoid chocolate using active (7:1 stimulus-to-frame contingency) and sham (1:1 stimulus-to-frame contingency) versions of these two trainings. Compared to sham, active irrelevant-feature training was associated with more selection and desire to eat fruit, and active dual-feature training increased approach bias for fruit. Participants' perceived rate of approaching fruit versus chocolate correlated with many outcome measures, suggesting contingency awareness plays a major role in AAT training effectiveness, challenging implicit accounts. While the dual-feature paradigm shows potential, its high error rates, RTs, and difficulty mandate improvement. FAU - Kahveci, Sercan AU - Kahveci S AUID- ORCID: 0000-0002-4139-5710 AD - Department of Psychology & Centre for Cognitive Neuroscience, Paris-Lodron-University of Salzburg, Salzburg, Austria. FAU - van Alebeek, Hannah AU - van Alebeek H AUID- ORCID: 0000-0002-3044-1486 AD - Department of Psychology & Centre for Cognitive Neuroscience, Paris-Lodron-University of Salzburg, Salzburg, Austria. FAU - Blechert, Jens AU - Blechert J AUID- ORCID: 0000-0002-3820-109X AD - Department of Psychology & Centre for Cognitive Neuroscience, Paris-Lodron-University of Salzburg, Salzburg, Austria. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241106 PL - England TA - Cogn Emot JT - Cognition & emotion JID - 8710375 SB - IM MH - Humans MH - Male MH - Female MH - *Food Preferences/psychology MH - Young Adult MH - *Awareness MH - Adult MH - *Avoidance Learning MH - Adolescent MH - Reaction Time MH - Chocolate MH - Fruit MH - Reproducibility of Results OTO - NOTNLM OT - Approach-avoidance task OT - chocolate consumption OT - cognitive bias modification OT - contingency awareness OT - eating behaviour EDAT- 2024/11/06 18:22 MHDA- 2025/06/24 18:30 CRDT- 2024/11/06 12:43 PHST- 2025/06/24 18:30 [medline] PHST- 2024/11/06 18:22 [pubmed] PHST- 2024/11/06 12:43 [entrez] AID - 10.1080/02699931.2024.2418445 [doi] PST - ppublish SO - Cogn Emot. 2025 Jun;39(4):876-898. doi: 10.1080/02699931.2024.2418445. Epub 2024 Nov 6. PMID- 39503699 OWN - NLM STAT- MEDLINE DCOM- 20250207 LR - 20260712 IS - 1878-2620 (Electronic) IS - 1499-4046 (Linking) VI - 57 IP - 2 DP - 2025 Feb TI - Validity and Reliability Assessment of a Food and Physical Activity Questionnaire for Adolescents From Low-Income Communities. PG - 120-131 LID - S1499-4046(24)00478-0 [pii] LID - 10.1016/j.jneb.2024.10.009 [doi] AB - OBJECTIVE: Develop and validate an evaluation questionnaire for sixth-12th grade Expanded Food and Nutrition Education Program (EFNEP) participants. DESIGN: Five-step process: domain concept prioritization, question generation, question pretesting, reliability testing, and criterion validity testing. SETTING: Community sites in 4 states and New Jersey EFNEP secondary program data. PARTICIPANTS: Nineteen sixth-12th graders were interviewed; secondary data included 164 ninth-12th graders. VARIABLES MEASURED: Content, face, and criterion validity; internal reliability. ANALYSIS: Iterative template analysis to gauge conceptual understanding; exploratory factor analysis with orthogonal Varimax rotation, interitem correlations, and Cronbach alpha; Spearman correlations and Bland-Altman plots against the Physical Activity Questionnaire for Adolescents and Youth Risk Behavior Survey questions. RESULTS: Fourteen questions with acceptable face validity were developed. One item (handwashing) had a ceiling effect and was removed. Eleven of the remaining 13 items were loaded onto 4 factors. The remaining 2 items were kept because of conceptual relevance. The questionnaire demonstrated acceptable reliability and validity overall, but subscale Cronbach alpha values ranged from 0.53-0.75. CONCLUSIONS AND IMPLICATIONS: This 13-item questionnaire was presented to national EFNEP program leaders and was implemented by EFNEP in October 2023. Further research could establish temporal reliability and gold standard criterion validity estimates with a multistate sample of sixth through 12th graders. CI - Copyright (c) 2024 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Bastian, Gemma E AU - Bastian GE AD - School of Health and Human Sciences, South Dakota State University, Brookings, SD. Electronic address: graham.bastian@sdstate.edu. FAU - Fitzgerald, Nurgul AU - Fitzgerald N AD - Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ. FAU - Baker, Susan S AU - Baker SS AD - Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO. FAU - Palmer-Keenan, Debra M AU - Palmer-Keenan DM AD - Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ. LA - eng PT - Journal Article PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Validation Study DEP - 20241105 PL - United States TA - J Nutr Educ Behav JT - Journal of nutrition education and behavior JID - 101132622 SB - IM MH - Humans MH - Adolescent MH - Surveys and Questionnaires/standards MH - Female MH - Reproducibility of Results MH - Male MH - *Exercise MH - *Poverty MH - Child OTO - NOTNLM OT - Expanded Food and Nutrition Education Program OT - adolescent behavior OT - health behavior OT - health education OT - psychometrics EDAT- 2024/11/06 16:18 MHDA- 2025/02/08 00:30 CRDT- 2024/11/06 10:35 PHST- 2023/02/21 00:00 [received] PHST- 2024/09/12 00:00 [revised] PHST- 2024/10/17 00:00 [accepted] PHST- 2025/02/08 00:30 [medline] PHST- 2024/11/06 16:18 [pubmed] PHST- 2024/11/06 10:35 [entrez] AID - S1499-4046(24)00478-0 [pii] AID - 10.1016/j.jneb.2024.10.009 [doi] PST - ppublish SO - J Nutr Educ Behav. 2025 Feb;57(2):120-131. doi: 10.1016/j.jneb.2024.10.009. Epub 2024 Nov 5. PMID- 39498605 OWN - NLM STAT- MEDLINE DCOM- 20241105 LR - 20250623 IS - 2150-1327 (Electronic) IS - 2150-1319 (Print) IS - 2150-1319 (Linking) VI - 15 DP - 2024 Jan-Dec TI - Impact of a Pediatric Produce Prescription Intervention on Food Security and Perceived Nutrition-Related Behaviors: A Mixed-Methods Study. PG - 21501319241276780 LID - 10.1177/21501319241276780 [doi] LID - 21501319241276780 AB - OBJECTIVES: Poor Food security (FS) is associated with risk of diet-related diseases and rising healthcare costs. Produce Prescription Interventions (PRx) are emerging clinical tools to improve FS and diet quality, but their impact in families with children is not well established. This study evaluates the impact of a pediatric PRx on FS and nutrition-related behaviors. METHODS: Adult caregivers of children (0-18) were enrolled within a 6-month produce delivery and nutrition education intervention. A validated food security survey was administered pre/post intervention to determine FS scores and "Food Secure" status. Statistical analyses tested pre-post differences in FS scores and proportion of scores within the "Food Secure" range. Semi-structured interviews were performed post-intervention to explore families' experiences with low FS and healthy behaviors and were thematically analyzed. RESULTS: Between October 2021 and December 2022, 82 families were enrolled, 65 completed FS survey at baseline and 54 completed it at post-intervention. FS scores improved post-intervention (P < .05) and a greater proportion of household- and child-level scores fell within the "Food Secure" range post-intervention (P < .05). Twenty-eight interviews were analyzed. Three salient themes were identified: (1) value of healthcare-based screening and intervention, (2) food and education motivate behavior change, and (3) perceptions of post-intervention lifestyle sustainability. CONCLUSIONS: Participation in the PRx was associated with improvements in FS and nutrition-related attitudes and behaviors. PRx can be implemented by health systems to improve FS and health behaviors associated with risk for diet-related diseases. Longer-term support may be needed to maintain healthy behavior changes associated with PRx participation. FAU - Muleta, Hemen AU - Muleta H AUID- ORCID: 0000-0002-6439-952X AD - Children's National Hospital, New York, NY, USA. AD - Albert Einstein College of Medicine, Bronx, NY, USA. FAU - Fischer, Laura AU - Fischer L AD - Children's National Hospital, New York, NY, USA. AD - George Washington University School of Medicine and Health Sciences, Washington, DC, USA. FAU - Ali, Qadira AU - Ali Q AD - Children's National Hospital, New York, NY, USA. AD - George Washington University School of Medicine and Health Sciences, Washington, DC, USA. FAU - Menezes, Shannon AU - Menezes S AD - George Washington University School of Medicine and Health Sciences, Washington, DC, USA. FAU - Kim, Noah AU - Kim N AD - Children's National Hospital, New York, NY, USA. FAU - Minkah-Premo, Emily AU - Minkah-Premo E AD - George Washington University Milken Institute School of Public Health, Washington, DC, USA. FAU - Essel, Kofi AU - Essel K AD - Children's National Hospital, New York, NY, USA. AD - George Washington University School of Medicine and Health Sciences, Washington, DC, USA. AD - Elevance Health, Indianapolis, IN, USA. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Prim Care Community Health JT - Journal of primary care & community health JID - 101518419 SB - IM MH - Humans MH - Female MH - Male MH - Child, Preschool MH - Child MH - Infant MH - *Food Security MH - Adult MH - Adolescent MH - Health Behavior MH - Caregivers/psychology MH - Diet PMC - PMC11536491 OTO - NOTNLM OT - community health OT - health promotion OT - lifestyle change OT - obesity OT - pediatrics OT - prevention OT - progam evaluation OT - qualitative methods OT - social determinants of health OT - underserved communities COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2024/11/05 06:21 MHDA- 2024/11/05 06:22 PMCR- 2024/11/05 CRDT- 2024/11/05 05:23 PHST- 2024/11/05 06:22 [medline] PHST- 2024/11/05 06:21 [pubmed] PHST- 2024/11/05 05:23 [entrez] PHST- 2024/11/05 00:00 [pmc-release] AID - 10.1177_21501319241276780 [pii] AID - 10.1177/21501319241276780 [doi] PST - ppublish SO - J Prim Care Community Health. 2024 Jan-Dec;15:21501319241276780. doi: 10.1177/21501319241276780. PMID- 39497086 OWN - NLM STAT- MEDLINE DCOM- 20241105 LR - 20241107 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 24 IP - 1 DP - 2024 Nov 4 TI - Development and validation of an ultrasound-based estimated fetal weight reference for Chinese twin pregnancy: a retrospective cohort study. PG - 718 LID - 10.1186/s12884-024-06924-y [doi] LID - 718 AB - BACKGROUND: Fetal growth monitoring is important for twin pregnancies. However, there has been no clinically validated tool for monitoring fetal growth of twin pregnancies in China. This study aims to develop and validate a chorionicity-specific growth chart of ultrasound estimated fetal weight (EFW) for Chinese twin pregnancies. METHODS: This retrospective cohort study included all twin pregnancies who delivered two live fetuses with gestational age >/= 34 weeks without severe obstetric complications at a tertiary hospital from January 2007 to March 2021. The participants were divided into a development set (delivered in or before December 2017) and a validation set (delivered in or after January 2018). Chorionicity-specific growth charts were created using the generalized additive models for location, scale, and shape (GAMLSS) based on the development set. The fetuses from the validation set were classified into three groups based on the last EFW: small-for-gestational-age (SGA) indicated by both the newly established twin charts and the Hadlock singleton chart currently used for twin pregnancies in China, suspected SGA indicated by only the singleton chart, and no SGA indicated by either chart. The incidence of neonatal outcomes among the three groups was then compared accordingly, including intensive care unit (NICU) stay length, respiratory diseases, and neurological disorders. RESULTS: The development set included 883 twin pregnancies and a total of 6374 EFW measurements between 16 and 38 weeks of gestation, and the validation set included 801 twin pregnancies and 7630 EFW measurements. In the development set, monochorionic diamniotic (MCDA) twins had a significantly lower EFW compared to dichorionic diamniotic (DCDA) twins beginning at 26 weeks, with the difference gradually increasing thereafter, supporting the establishment of chorionicity-specific growth charts. Of the 1,602 twin neonates in the validation set, 103 (6.4%) were classified into the SGA group, 164 (10.2%) into the suspected SGA group, and 1335 (83.3%) into the no SGA group. The incidence of respiratory diseases and neurological disorders was comparable between the suspected SGA group and the no SGA group, but apparently higher in the SGA group. Meanwhile, NICU stay lengths were consistently longer for twins in the SGA group compared to the no SGA group (difference: 0.57, 95% CI: 0.31-0.83), with no significant differences observed between the suspected SGA and no SGA groups. CONCLUSIONS: The fetal growth trajectories differed by chorionicity, with a lower EFW for MCDA twins beginning at 26 weeks. The establishment of chorionicity-specific growth chart could reduce overdiagnosis of SGA and improve fetal growth monitoring of twin pregnancies. CI - (c) 2024. The Author(s). FAU - Yang, Jing AU - Yang J AD - Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. FAU - Yu, Hongzhao AU - Yu H AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Peking University Health Science Center, Beijing, China. FAU - Zhao, Yangyu AU - Zhao Y AD - Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. FAU - Cheng, Zhihao AU - Cheng Z AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Peking University Health Science Center, Beijing, China. FAU - Du, Yufeng AU - Du Y AD - Department of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, 730000, China. FAU - Yuan, Pengbo AU - Yuan P AD - Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. FAU - Zhang, Aiqing AU - Zhang A AD - Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. FAU - Liu, Yang AU - Liu Y AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Peking University Health Science Center, Beijing, China. FAU - Gong, Xiaoli AU - Gong X AD - Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. FAU - Yu, Yang AU - Yu Y AD - Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. FAU - Li, Yixin AU - Li Y AD - Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. FAU - You, Xiaoyan AU - You X AD - Department of Obstetrics and Gynecology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, 450000, China. FAU - Huang, Nana AU - Huang N AD - Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. FAU - Zhang, Youzhen AU - Zhang Y AD - Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. FAU - Sun, Xiya AU - Sun X AD - Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. FAU - Qi, Hongbo AU - Qi H AD - Department of Obstetrics and Gynecology, Women and Children's Hospital of Chongqing Medical University, Chongqing, 401147, China. qihongbo728@163.com. FAU - Li, Hong-Tian AU - Li HT AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Peking University Health Science Center, Beijing, China. lihongtian@pku.edu.cn. AD - Center for Intelligent Public Health, Institute for Artificial Intelligence, Peking University, Beijing, 100191, China. lihongtian@pku.edu.cn. FAU - Wei, Yuan AU - Wei Y AD - Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. weiyuanbysy@163.com. LA - eng GR - 2022YFA1303900/National Key Research and Development Program of China/ GR - 2023YFC2705900/National Key Research and Development Program of China/ GR - PKU2023XGK015/Emerging Engineering Interdisciplinary Young Scholars Project of Peking University/ GR - PKU2021LCXQ009/Clinical Medicine Plus X-Young Scholars Project of Peking University/ PT - Journal Article PT - Validation Study DEP - 20241104 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Retrospective Studies MH - *Pregnancy, Twin MH - *Ultrasonography, Prenatal MH - *Fetal Weight MH - China/epidemiology MH - Adult MH - Infant, Newborn MH - Infant, Small for Gestational Age MH - Gestational Age MH - Growth Charts MH - Fetal Development/physiology MH - Cohort Studies MH - Reference Values MH - Fetal Growth Retardation/diagnostic imaging/epidemiology MH - East Asian People PMC - PMC11536931 OTO - NOTNLM OT - Adverse outcomes OT - Chorionicity OT - Estimated fetal weight OT - Fetal growth restriction OT - Growth charts OT - Small for gestational age OT - Twin pregnancy COIS- The authors declare no competing interests. EDAT- 2024/11/05 00:21 MHDA- 2024/11/05 07:20 PMCR- 2024/11/04 CRDT- 2024/11/04 23:46 PHST- 2024/01/22 00:00 [received] PHST- 2024/10/24 00:00 [accepted] PHST- 2024/11/05 07:20 [medline] PHST- 2024/11/05 00:21 [pubmed] PHST- 2024/11/04 23:46 [entrez] PHST- 2024/11/04 00:00 [pmc-release] AID - 10.1186/s12884-024-06924-y [pii] AID - 6924 [pii] AID - 10.1186/s12884-024-06924-y [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2024 Nov 4;24(1):718. doi: 10.1186/s12884-024-06924-y. PMID- 39496983 OWN - NLM STAT- MEDLINE DCOM- 20241104 LR - 20241107 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 29 IP - 1 DP - 2024 Nov 4 TI - Transcultural adaptation and validation of the Eating Self-Efficacy Brief Scale (ESEBS): the Brazilian version. PG - 70 LID - 10.1007/s40519-024-01703-2 [doi] LID - 70 AB - PURPOSE: This study aimed to develop and validate the Brief Eating Self-Efficacy Scale (ESEBS-BR) in Brazilian Portuguese, addressing the lack of tools to assess eating self-efficacy beliefs in Portuguese-speaking populations. METHOD: The study sought to cross-culturally adapt the scale, evaluate its internal structure, validate its reliability and validity, and explore potential associations between eating self-efficacy and eating behaviors. The cross-cultural adaptation process involved translation and back-translation, expert committees, and pre-testing. Scale validation was conducted with 228 participants, including reliability analyses, confirmatory factor analysis, and correlations with established measures of eating behavior. RESULTS: The ESEBS-BR, maintaining all 8 original items, demonstrated high reliability, with a two-factor structure model confirmed by confirmatory factor analysis. Significant correlations were found between ESEBS-BR scores and measures of binge eating and eating behaviors, validating its criterion validity. CONCLUSIONS: The development and validation of the ESEBS-BR represent a significant contribution to the assessment of eating self-efficacy in the Brazilian population. The scale proved to be sensitive, reliable, and valid, offering an important tool for research and clinical interventions related to eating behavior. LEVEL OF EVIDENCE: V, descriptive cross-sectional study. CI - (c) 2024. The Author(s). FAU - Feoli, Ana Maria Pandolfo AU - Feoli AMP AUID- ORCID: 0000-0001-7685-8431 AD - Eating Behavior Group of the Psychology Postgraduate Program, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do sul, Porto Alegre, 90619-900, Brazil. FAU - da Silva, Taina Lopes AU - da Silva TL AUID- ORCID: 0000-0002-6238-2273 AD - Eating Behavior Group of the Psychology Postgraduate Program, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do sul, Porto Alegre, 90619-900, Brazil. FAU - de Souza Urbanetto, Janete AU - de Souza Urbanetto J AUID- ORCID: 0000-0002-4697-1641 AD - School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do sul, Ipiranga Avenue 6681 - Partenon, Porto Alegre, RS, 90619-900, Brazil. FAU - D'Amico, Monica AU - D'Amico M AUID- ORCID: 0009-0009-7832-5802 AD - Department of Psychology, Sapienza University of Rome, Via Dei Marsi 78, 2nd Floor, 00185, Rome, Italy. monica.damico@uniroma1.it. FAU - Cerolini, Silvia AU - Cerolini S AUID- ORCID: 0000-0003-1447-7347 AD - Department of Psychology, Sapienza University of Rome, Via Dei Marsi 78, 2nd Floor, 00185, Rome, Italy. AD - Department of Human Sciences, Guglielmo Marconi University, Via Plinio 44, 00196, Rome, Italy. FAU - Lombardo, Caterina AU - Lombardo C AUID- ORCID: 0000-0002-5245-1757 AD - Department of Psychology, Sapienza University of Rome, Via Dei Marsi 78, 2nd Floor, 00185, Rome, Italy. caterina.lombardo@uniroma1.it. LA - eng GR - 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ PT - Journal Article PT - Validation Study DEP - 20241104 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - *Self Efficacy MH - Brazil MH - Female MH - Adult MH - Reproducibility of Results MH - *Feeding Behavior/psychology MH - Male MH - *Psychometrics MH - Young Adult MH - Surveys and Questionnaires/standards MH - Cross-Sectional Studies MH - Cross-Cultural Comparison MH - Adolescent MH - Middle Aged MH - Factor Analysis, Statistical MH - Translations PMC - PMC11534980 OTO - NOTNLM OT - Eating behavior OT - Eating self-efficacy OT - Scale OT - Validation COIS- The authors declare no competing interests. EDAT- 2024/11/05 00:21 MHDA- 2024/11/05 00:22 PMCR- 2024/11/04 CRDT- 2024/11/04 23:41 PHST- 2024/07/03 00:00 [received] PHST- 2024/10/27 00:00 [accepted] PHST- 2024/11/05 00:22 [medline] PHST- 2024/11/05 00:21 [pubmed] PHST- 2024/11/04 23:41 [entrez] PHST- 2024/11/04 00:00 [pmc-release] AID - 10.1007/s40519-024-01703-2 [pii] AID - 1703 [pii] AID - 10.1007/s40519-024-01703-2 [doi] PST - epublish SO - Eat Weight Disord. 2024 Nov 4;29(1):70. doi: 10.1007/s40519-024-01703-2. PMID- 39495545 OWN - NLM STAT- MEDLINE DCOM- 20251022 LR - 20260813 IS - 2238-0019 (Electronic) IS - 2237-6089 (Print) IS - 2237-6089 (Linking) VI - 47 DP - 2025 TI - Smartphone dependence predicts poorer mental health outcomes, eating behaviors, activity levels, and body image: a cluster analysis of Brazilian university students. PG - e20240904 LID - 10.47626/2237-6089-2024-0904 [doi] LID - e20240904 AB - OBJECTIVE: Excessive smartphone use has been linked to mental health impairments and may potentially alter human behavior. These effects are particularly pronounced among younger individuals, with university students being especially susceptible to the negative influences of smartphone use. METHODS: This observational, cross-sectional study was conducted in a sample of 781 Brazilian university students. We assessed socio-economic variables, smartphone addiction, depression, anxiety, stress outcomes, eating behavior, body image satisfaction, and self-reported physical activity. Multivariate analysis of variance (MANOVA) and chi-square tests were performed to compare continuous and categorical variables between genders. K-means clustering was used to identify participant profiles based on various self-reported variables, with differences between clusters validated using the Z-test and the silhouette coefficient. RESULTS: Three clusters were identified. Cluster 1 featured participants with a significant disparity between their perceived and desired body image, higher scores on eating disorders, smartphone addiction, and mental health questionnaires, and lower levels of physical exercise. Cluster 2 consisted of older participants who scored lower for smartphone addiction and mental health and had a higher body mass index (BMI). Cluster 3 included younger participants with a smaller Silhouette Scale disparity, lower eating disorder scores, and lower BMI. Smartphone addiction showed significant associations with eating disorders in the overall eating disorders classification (chi(2) = 13.4; p < 0.001), bulimic behavior (chi(2) = 20.0; p < 0.001), and social pressure to eat (chi(2) = 4.3; p < 0.001). It also negatively correlated with physical exercise (chi(2) = 5.7; p = 0.017), but not with dieting concerns (chi(2) = 0.23; p = 0.688). CONCLUSION: Smartphone addiction is associated with eating disorders, stress, depression, anxiety, and lower levels of physical activity. FAU - Lima, Karen Rodrigues AU - Lima KR AD - Departamento de Ciencias da Saude, Universidade Federal de Lavras, Lavras, MG, Brazil. FAU - Amorim, Barbara Isabela AU - Amorim BI AD - Departamento de Ciencias da Saude, Universidade Federal de Lavras, Lavras, MG, Brazil. FAU - Orlando, Debora Ribeiro AU - Orlando DR AD - Departamento de Ciencias da Saude, Universidade Federal de Lavras, Lavras, MG, Brazil. FAU - Pereira, Luciano Jose AU - Pereira LJ AD - Departamento de Ciencias da Saude, Universidade Federal de Lavras, Lavras, MG, Brazil. FAU - Castelo, Paula Midori AU - Castelo PM AD - Departamento de Ciencias Farmaceuticas, Universidade Federal de Sao Paulo, Diadema, SP, Brazil. FAU - Andrade, Eric Francelino AU - Andrade EF AD - Departamento de Ciencias da Saude, Universidade Federal de Lavras, Lavras, MG, Brazil. LA - eng PT - Journal Article PT - Observational Study DEP - 20241104 PL - Brazil TA - Trends Psychiatry Psychother JT - Trends in psychiatry and psychotherapy JID - 101610695 SB - IM MH - Humans MH - Female MH - Male MH - Brazil/epidemiology MH - Cross-Sectional Studies MH - *Body Image/psychology MH - Young Adult MH - *Students/psychology/statistics & numerical data MH - Universities MH - Adult MH - *Feeding and Eating Disorders/epidemiology/psychology MH - Cluster Analysis MH - *Exercise/psychology MH - *Smartphone MH - *Feeding Behavior/psychology MH - *Internet Addiction Disorder/epidemiology/psychology MH - Adolescent MH - Anxiety/epidemiology MH - Depression/epidemiology MH - Stress, Psychological/epidemiology MH - Mental Health PMC - PMC12956141 OTO - NOTNLM OT - Internet addiction disorder OT - anxiety OT - body image OT - depression OT - feeding and eating disorders COIS- No conflicts of interest declared concerning the publication of this article. EDAT- 2024/11/04 12:23 MHDA- 2025/10/22 12:31 PMCR- 2025/09/09 CRDT- 2024/11/04 11:52 PHST- 2024/07/01 00:00 [received] PHST- 2024/10/25 00:00 [accepted] PHST- 2025/10/22 12:31 [medline] PHST- 2024/11/04 12:23 [pubmed] PHST- 2024/11/04 11:52 [entrez] PHST- 2025/09/09 00:00 [pmc-release] AID - 10.47626/2237-6089-2024-0904 [doi] PST - ppublish SO - Trends Psychiatry Psychother. 2025;47:e20240904. doi: 10.47626/2237-6089-2024-0904. Epub 2024 Nov 4. PMID- 39494824 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260730 LR - 20260730 IS - 1475-2662 (Electronic) IS - 0007-1145 (Linking) VI - 132 IP - 9 DP - 2024 Nov 14 TI - The relationship between the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet and metabolic health status in adolescents with overweight and obesity: results from a cross-sectional study in Iran. PG - 1134-1142 LID - 10.1017/S0007114524002381 [doi] AB - Few studies investigated the association between Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet and metabolic health status, particularly among adolescents. The present study was designed to investigate the association of MIND diet with metabolic health status in Iranian adolescents with overweight/obesity. This cross-sectional study was done among 203 adolescents with overweight/obesity (12-18 years) in Isfahan, Iran. A validated FFQ was applied to collect dietary intakes. Anthropometric indices and blood pressure were also measured by standard procedures. Fasting blood samples were obtained to determine serum insulin, glucose and lipid profile. To categorise participants as being with metabolically healthy overweight/obesity (MHO) or metabolically unhealthy overweight/obesity (MUO), two methods including International Diabetes Federation (IDF) criteria and IDF plus Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) were applied. Participants had a mean age of 13.98 years and 50.2 % of them were girls. In fully adjusted models, participants with highest MIND diet adherence had lower odds of MUO status based on IDF (OR = 0.20; 95 % CI 0.08, 0.51) and IDF/HOMA-IR (OR = 0.22; 95 % CI 0.08, 0.59) criteria. Stratified analyses revealed that this association was stronger among girls and was only significant among individuals with overweight. An inverse association was also found between MIND diet score and odds of hyperglycaemia and insulin resistance (IR). Higher MIND diet adherence was associated with lower odds MUO in adolescents with overweight/obesity. Inverse associations were also found between MIND diet and odds of hyperglycaemia and IR. Future longitudinal prospective studies are necessary to confirm our results. FAU - Khakbaz, Maryam AU - Khakbaz M AD - Department of Clinical Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. FAU - Poursalehi, Donya AU - Poursalehi D AUID- ORCID: 0000-0003-1020-5707 AD - Students' Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran. AD - Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Mirzaei, Saeideh AU - Mirzaei S AD - Department of Community Nutrition, School of Nutrition and Food Science, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Asadi, Ali AU - Asadi A AD - Department of Exercise Physiology, School of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran. FAU - Akhlaghi, Masoumeh AU - Akhlaghi M AD - Department of Community Nutrition, School of Nutrition and Food Science, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Saneei, Parvane AU - Saneei P AD - Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. LA - eng PT - Journal Article DEP - 20241104 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM OTO - NOTNLM OT - Adolescents OT - MIND diet OT - Metabolic health status OT - Obesity OT - Overweight EDAT- 2024/11/04 12:25 MHDA- 2024/11/04 12:26 CRDT- 2024/11/04 07:43 PHST- 2024/11/04 12:26 [medline] PHST- 2024/11/04 12:25 [pubmed] PHST- 2024/11/04 07:43 [entrez] AID - S0007114524002381 [pii] AID - 10.1017/S0007114524002381 [doi] PST - ppublish SO - Br J Nutr. 2024 Nov 14;132(9):1134-1142. doi: 10.1017/S0007114524002381. Epub 2024 Nov 4. PMID- 39494786 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260730 LR - 20260730 IS - 1475-2662 (Electronic) IS - 0007-1145 (Linking) VI - 132 IP - 9 DP - 2024 Nov 14 TI - Association between sleep timing and meal and snack patterns in schoolchildren in southern Brazil. PG - 1233-1244 LID - 10.1017/S0007114524002617 [doi] AB - This study aimed to identify meal and snack patterns and assess their association with sleep timing in schoolchildren. This is a cross-sectional study carried out in 2018/2019 with 1333 schoolchildren aged 7-14 years from public and private schools in Florianopolis, Brazil. Previous-day dietary intake data for breakfast, mid-morning snack, lunch, mid-afternoon snack, dinner and evening snack were collected using a validated online questionnaire. Sleep timing was measured by the midpoint of sleep and classified as quartiles (very early, early, late and very late). Latent class analysis was performed to identify meal and snack patterns, and multinomial logistic regression was used to assess associations. Students with very late sleep timing were less likely to consume the 'coffee with milk, bread and cheese' breakfast pattern compared with very early group. Also, the former were more likely to consume the 'mixed' breakfast pattern (healthy and unhealthy foods) compared with very early students. The latter were more likely to eat the 'Brazilian traditional, processed meat, egg and fish' lunch pattern to the late students and less likely to consume the 'pasta and cheese' lunch pattern compared with the students with later sleep timing. Students with later sleep timing were more likely to eat ultra-processed food at mid-afternoon snacks compared with early group. The study findings suggest that morning preference appears to promote healthier breakfast, lunch and afternoon snack patterns, whereas later sleep timing may pose challenges in maintaining healthy patterns at these meals/snacks. FAU - Roberto, Denise Miguel Teixeira AU - Roberto DMT AUID- ORCID: 0000-0003-2234-7323 AD - Post-Graduation Program in Nutrition, Center of Health Sciences, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil. FAU - Kupek, Emil AU - Kupek E AUID- ORCID: 0000-0001-6704-1673 AD - Department of Public Health, Center for Health Sciences, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil. FAU - Spanholi, Mariana Winck AU - Spanholi MW AD - Post-Graduation Program in Nutrition, Center of Health Sciences, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil. FAU - Lemke, Stella AU - Lemke S AUID- ORCID: 0000-0002-5503-5038 AD - Post-Graduation Program in Nutrition, Center of Health Sciences, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil. FAU - Pereira, Luciana Jeremias AU - Pereira LJ AD - Post-Graduation Program in Nutrition, Center of Health Sciences, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil. FAU - Di Pietro, Patricia Faria AU - Di Pietro PF AUID- ORCID: 0000-0003-1343-5049 AD - Post-Graduation Program in Nutrition, Center of Health Sciences, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil. FAU - Vieira, Francilene Gracieli Kunradi AU - Vieira FGK AUID- ORCID: 0000-0003-4211-9133 AD - Post-Graduation Program in Nutrition, Center of Health Sciences, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil. FAU - Hinnig, Patricia de Fragas AU - Hinnig PF AD - Post-Graduation Program in Nutrition, Center of Health Sciences, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil. LA - eng PT - Journal Article DEP - 20241104 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM OTO - NOTNLM OT - Breakfast OT - Children OT - Chronotype OT - Dietary pattern OT - Latent Class analysis OT - Snacks EDAT- 2024/11/04 12:24 MHDA- 2024/11/04 12:25 CRDT- 2024/11/04 07:33 PHST- 2024/11/04 12:25 [medline] PHST- 2024/11/04 12:24 [pubmed] PHST- 2024/11/04 07:33 [entrez] AID - S0007114524002617 [pii] AID - 10.1017/S0007114524002617 [doi] PST - ppublish SO - Br J Nutr. 2024 Nov 14;132(9):1233-1244. doi: 10.1017/S0007114524002617. Epub 2024 Nov 4. PMID- 39493044 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241105 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 16 IP - 10 DP - 2024 Oct TI - Translation, Cultural Adaptation, and Validation of the Arab Version of the Adolescent Food Parenting Questionnaire (AFPQ) in Kut City, Iraq. PG - e70739 LID - 10.7759/cureus.70739 [doi] LID - e70739 AB - Background Food parenting behaviors have been increasingly critical to adolescent nutritional health. These behaviors play a decisive role in shaping food intake and weight status in adolescents through autonomy support, coercive control, modeling habits, healthy structure, and determining snacking patterns. To our knowledge, there is no available food parenting questionnaire in the Arabic version; therefore, a reliable and validated Arabic version of the questionnaire to assess food parenting behavior among Iraqi adolescents is required. The aim of this study was to translate, culturally adapt, and validate the Adolescent Food Parenting Questionnaire (AFPQ) into Arabic (AFPQ-A) for adolescents aged 16 to 18 in Kut City, Iraq. Methodology The original version of AFPQ was translated according to a 10-step protocol after being authorized by the developer. The modified kappa statistic (kappa(m)), the sum content validity index/universal agreement (S-CVI/UA) method, the scale-level content validity index average (S-CVI/Ave), and the item-level content validity index (I-CVI) were used by four independent experts to assess the content validity of the AFPQ for adolescents and parenting. Face validity was assessed among the adolescents (n = 30) and their respective parents. Results The translation process into the Arabic version produced minor modifications to the original questionnaire. The S-CVI/Ave score for the parent version was 0.95, while the I-CVI/UA score was 0.81 for the adolescent version. The kappa(m) values of 1.00 were found in the majority of the items. These scores indicated that the AFPQ items possessed good content validity. Both the parent and adolescent versions demonstrated excellent face validity, with the sum of face validity index/average (S-FVI) scores of 0.95 and 0.94, respectively. Conclusion The AFPQ-A has been demonstrated to be a valid and reliable instrument for the assessment of food parenting behaviors in Iraqi adolescents. CI - Copyright (c) 2024, Alkinani et al. FAU - Alkinani, Abbas Ali AU - Alkinani AA AD - Department of Community Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, MYS. FAU - Rohana, A J AU - Rohana AJ AD - Department of Community Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, MYS. FAU - Hasan, Ruhaya AU - Hasan R AD - School of Dental Sciences, Universiti Sains Malaysia, Kubang Kerian, MYS. FAU - W Ahmad, Wan Muhamad Amir AU - W Ahmad WMA AD - School of Dental Sciences, Universiti Sains Malaysia, Kubang Kerian, MYS. FAU - Al-Badri, Saad Abid AU - Al-Badri SA AD - Department of Internal Medicine, College of Medicine, Wasit University, Wasit, IRQ. LA - eng PT - Journal Article DEP - 20241002 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC11531338 OTO - NOTNLM OT - adolescent OT - adolescent food parenting behaviors OT - arabic translation OT - cultural adaptation OT - translation OT - validation COIS- Human subjects: Consent was obtained or waived by all participants in this study. Human Research Ethics Committee at the Universiti Sains Malaysia issued approval USM/JEPeM/KK/23030276. The following documents have been approved for use in the study. 1. Research Proposal In addition to the abovementioned documents, the following technical documents were included in the review on which this approval was based: 1. Participant Information Sheet and Consent Form (English version) - Phase I 2. Participant Information Sheet and Consent Form (Arabic version) - Phase I 3. Participant Information Sheet and Consent Form (English version) - Phase II 4. Participant Information Sheet and Consent Form (Arabic version) - Phase II 5. Questionnaires. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2024/11/04 06:23 MHDA- 2024/11/04 06:24 PMCR- 2024/10/02 CRDT- 2024/11/04 04:58 PHST- 2024/10/02 00:00 [accepted] PHST- 2024/11/04 06:24 [medline] PHST- 2024/11/04 06:23 [pubmed] PHST- 2024/11/04 04:58 [entrez] PHST- 2024/10/02 00:00 [pmc-release] AID - 10.7759/cureus.70739 [doi] PST - epublish SO - Cureus. 2024 Oct 2;16(10):e70739. doi: 10.7759/cureus.70739. eCollection 2024 Oct. PMID- 39492978 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260813 IS - 0972-978X (Print) IS - 0972-978X (Electronic) IS - 0972-978X (Linking) VI - 61 DP - 2025 Mar TI - Primary ACL repair in a selected patient cohort: A prospective single cohort study. PG - 127-132 LID - 10.1016/j.jor.2024.09.020 [doi] AB - BACKGROUND: Anterior cruciate ligament (ACL) tears are common knee injuries, particularly in physically active individuals. While ACL reconstruction (ACL-R) is the standard treatment, it has notable limitations. Recent interest in primary ACL repair offers a potential alternative, especially for specific tear types and patient demographics. PURPOSE: To evaluate the outcomes of primary ACL repair in a selected patient cohort with strict inclusion and exclusion criteria, focusing on the survival of the procedure, functional outcomes, and factors influencing success rates. METHODS: This prospective single cohort study included 61 patients who underwent primary ACL repair between June 2016 and June 2022. Patients were 50 years or younger, with recent ACL injuries and no previous knee surgeries or multiligament injuries. The primary outcomes were the survival of the repair beyond two years, measured by revision rates, and functional outcomes assessed using the Lysholm knee score, Tegner activity scale, and Lachmeter stability measurements. RESULTS: Fifty-four patients completed a minimum follow-up of three years (average 49.6 months). The overall success rate was 82.2 %, with Sherman type 1 tears showing significantly fewer failures compared to type 2 (4.3 % vs. 31.8 %). The mean Lysholm score for successful repairs was 96, and the Tegner score dropped from a pre-injury average of 6 to 5. Adolescents had the highest failure rate (50 %), while other age groups showed better outcomes. The mean side-to-side difference in stability was 1.4 mm, favoring the control side. CONCLUSION: Primary ACL repair is a viable option for selected patients, particularly those with Sherman type 1 tears. While age and tear type significantly affect outcomes, the procedure shows promising results with high functional scores in successful repairs. Further research with larger cohorts and extended follow-ups is necessary to validate these findings and refine patient selection criteria. Primary ACL repair offers a less invasive alternative to ACL reconstruction, with potential for comparable outcome. CI - (c) 2024 Professor P K Surendran Memorial Education Foundation. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies. FAU - Al Kindi, Ibtihal AU - Al Kindi I AD - Orthopedic Surgery Department, Sultan Qaboos University Hospital, Muscat, Oman. FAU - Al Rawahi, Salim AU - Al Rawahi S AD - Division of Orthopedic Surgery, Department of Surgery, McGill University, Montreal, Quebec, Canada. FAU - Al Ghaithi, Ahmed AU - Al Ghaithi A AD - Orthopedic Surgery Department, Sultan Qaboos University Hospital, Muscat, Oman. FAU - Al Yarubi, Said AU - Al Yarubi S AD - Physiotherapy Department, Sultan Qaboos University Hospital, Muscat, Oman. FAU - Al Masakri, Sultan AU - Al Masakri S AD - Orthopedic Surgery Department, Sultan Qaboos University Hospital, Muscat, Oman. FAU - Al Mutaini, Mohammed AU - Al Mutaini M AD - Orthopedic Surgery Department, Sultan Qaboos University Hospital, Muscat, Oman. LA - eng PT - Journal Article DEP - 20241002 PL - Netherlands TA - J Orthop JT - Journal of orthopaedics JID - 101233220 PMC - PMC11526054 OTO - NOTNLM OT - ACL avulsion OT - ACL injuries OT - ACL reconstruction OT - ACL repair OT - Sherman type COIS- Written informed consent after through and detailed explanation of the study and the procedure was taken from all the study participants. Surgery was performed at the earliest opportunity following clinical and radiological diagnosis. EDAT- 2024/11/04 06:23 MHDA- 2024/11/04 06:24 PMCR- 2026/03/01 CRDT- 2024/11/04 04:57 PHST- 2024/08/13 00:00 [received] PHST- 2024/09/27 00:00 [accepted] PHST- 2024/11/04 06:24 [medline] PHST- 2024/11/04 06:23 [pubmed] PHST- 2024/11/04 04:57 [entrez] PHST- 2026/03/01 00:00 [pmc-release] AID - S0972-978X(24)00327-1 [pii] AID - 10.1016/j.jor.2024.09.020 [doi] PST - epublish SO - J Orthop. 2024 Oct 2;61:127-132. doi: 10.1016/j.jor.2024.09.020. eCollection 2025 Mar. PMID- 39489399 OWN - NLM STAT- MEDLINE DCOM- 20241204 LR - 20260609 IS - 1559-2030 (Electronic) IS - 1551-7144 (Print) IS - 1551-7144 (Linking) VI - 147 DP - 2024 Dec TI - Healthy Drinks, Healthy Teeth - Ciunerkaq Tanqigtuq (The Future is Bright): A study protocol for a community-based, non-randomized sociobehavioral trial to reduce added sugar intake in Alaska Native Yup'ik children in the Yukon-Kuskokwim Delta. PG - 107734 LID - S1551-7144(24)00317-3 [pii] LID - 10.1016/j.cct.2024.107734 [doi] AB - BACKGROUND: This study protocol describes a community-based intervention that will seek to reduce added sugar intake in Yup'ik Alaska Native children by targeting reductions in sugar-sweetened fruit drinks. METHODS: A two-group non-randomized design will be used to evaluate the intervention in three Yup'ik communities in Alaska focusing on children age 1 to less than age 12 years with a minimum enrollment target of 192 children. Families in the intervention arm will participate in a program consisting of five sessions plus four brief check-ins, all delivered by a Yup'ik Community Health Worker. Modifications to the local store environment will be made to give families a place to purchase sugar-free water enhancers. Families in the delayed treatment control arm will receive no intervention during the main study period. There will be five data collection visits (baseline, 1-month, 3-months, 6-months, and 12-months) that will include collection of survey and dietary data, and a hair and plaque sample from each participating child. The outcomes will be change, from baseline to 6 months, in added sugar intake based on a validated hair biomarker (grams of added sugar/day). We hypothesize children in the intervention arm will have greater reductions in added sugar intake compared to children in the control arm as measured by the hair biomarker. DISCUSSION: This is one of the first known community-based sociobehavioral interventions aimed specifically at reducing added sugar intake in Alaska Native communities by targeting sugar-sweetened fruit drinks. TRIAL REGISTRATION: ClinicalTrials.govNCT05219448 (first posted on February 2, 2022). CI - Copyright (c) 2024 Elsevier Inc. All rights reserved. FAU - Chi, Donald L AU - Chi DL AD - Department of Oral Health Sciences, University of Washington School of Dentistry, 1959 NE Pacific Street, Box 357475, Seattle, WA 98195, USA; Department of Health Systems and Population Health, University of Washington School of Public Health, 3980 15th Ave NE, Fourth Floor, Box 351621, Seattle, WA 98195, USA. Electronic address: dchi@uw.edu. FAU - Lewis, Frances Marcus AU - Lewis FM AD - Department of Child, Family and Population Health Nursing, University of Washington School of Nursing, Health Sciences Building, Room T-301, 1959 NE Pacific Street, Seattle, WA, 98195, USA. FAU - Weinstein, Philip AU - Weinstein P AD - Department of Oral Health Sciences, University of Washington School of Dentistry, 1959 NE Pacific Street, Box 357475, Seattle, WA 98195, USA. FAU - Mancl, Lloyd AU - Mancl L AD - Department of Oral Health Sciences, University of Washington School of Dentistry, 1959 NE Pacific Street, Box 357475, Seattle, WA 98195, USA. FAU - Milgrom, Peter AU - Milgrom P AD - Department of Oral Health Sciences, University of Washington School of Dentistry, 1959 NE Pacific Street, Box 357475, Seattle, WA 98195, USA. FAU - Edwards, Todd AU - Edwards T AD - Department of Health Systems and Population Health, University of Washington School of Public Health, 3980 15th Ave NE, Fourth Floor, Box 351621, Seattle, WA 98195, USA. FAU - Coldwell, Susan AU - Coldwell S AD - Department of Oral Health Sciences, University of Washington School of Dentistry, 1959 NE Pacific Street, Box 357475, Seattle, WA 98195, USA. FAU - O'Brien, Diane AU - O'Brien D AD - Center for Alaska Native Health Research, Institute of Arctic Biology, University of Alaska Fairbanks, 2141 Koyukuk Dr, Fairbanks, AK 99775, USA. FAU - Bersamin, Andrea AU - Bersamin A AD - Center for Alaska Native Health Research, Institute of Arctic Biology, University of Alaska Fairbanks, 2141 Koyukuk Dr, Fairbanks, AK 99775, USA. FAU - Hopkins, Scarlett AU - Hopkins S AD - Department of Obstetrics and Gynecology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. FAU - Orr, Eliza AU - Orr E AD - Department of Oral Health Sciences, University of Washington School of Dentistry, 1959 NE Pacific Street, Box 357475, Seattle, WA 98195, USA. FAU - Rivera, Patricia AU - Rivera P AD - Center for Alaska Native Health Research, Institute of Arctic Biology, University of Alaska Fairbanks, 2141 Koyukuk Dr, Fairbanks, AK 99775, USA. FAU - Lenaker, Dane AU - Lenaker D AD - Southeast Alaska Regional Health Consortium, Department of Dentistry, 3245 Hospital Drive, Juneau, AK 99801, USA. FAU - Sylvetsky, Allison AU - Sylvetsky A AD - Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, 950 New Hampshire Ave NW, Washington, DC 20052,USA. FAU - Gittelsohn, Joel AU - Gittelsohn J AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA. FAU - Walter, Peter AU - Walter P AD - Clinical Mass Spectrometry Core, NIH/NIDDK, Building 10-9C106, 10 Center Drive, MSC-1805, Bethesda, MD 20892, USA. FAU - Randall, Cameron L AU - Randall CL AD - Department of Oral Health Sciences, University of Washington School of Dentistry, 1959 NE Pacific Street, Box 357475, Seattle, WA 98195, USA. FAU - Wiseman, Deanna AU - Wiseman D AD - Department of Oral Health Sciences, University of Washington School of Dentistry, 1959 NE Pacific Street, Box 357475, Seattle, WA 98195, USA. FAU - Dock, Andrea AU - Dock A AD - Department of Oral Health Sciences, University of Washington School of Dentistry, 1959 NE Pacific Street, Box 357475, Seattle, WA 98195, USA. FAU - Ko, Alice AU - Ko A AD - Department of Oral Health Sciences, University of Washington School of Dentistry, 1959 NE Pacific Street, Box 357475, Seattle, WA 98195, USA. FAU - Orack, Joshua AU - Orack J AD - Department of Oral Health Sciences, University of Washington School of Dentistry, 1959 NE Pacific Street, Box 357475, Seattle, WA 98195, USA. FAU - Nemawarkar, Deeksha AU - Nemawarkar D AD - Department of Oral Health Sciences, University of Washington School of Dentistry, 1959 NE Pacific Street, Box 357475, Seattle, WA 98195, USA. FAU - Panchal, Shraddha AU - Panchal S AD - Department of Oral Health Sciences, University of Washington School of Dentistry, 1959 NE Pacific Street, Box 357475, Seattle, WA 98195, USA. FAU - Soper, Jane AU - Soper J AD - Department of Oral Health Sciences, University of Washington School of Dentistry, 1959 NE Pacific Street, Box 357475, Seattle, WA 98195, USA. FAU - Hill, Courtney M AU - Hill CM AD - Department of Oral Health Sciences, University of Washington School of Dentistry, 1959 NE Pacific Street, Box 357475, Seattle, WA 98195, USA. FAU - Kerr, Darragh AU - Kerr D AD - Department of Oral Health Sciences, University of Washington School of Dentistry, 1959 NE Pacific Street, Box 357475, Seattle, WA 98195, USA. FAU - Nguyen, Daisy Patino AU - Nguyen DP AD - Department of Oral Health Sciences, University of Washington School of Dentistry, 1959 NE Pacific Street, Box 357475, Seattle, WA 98195, USA. FAU - Chen, Chien-Yu AU - Chen CY AD - Department of Oral Health Sciences, University of Washington School of Dentistry, 1959 NE Pacific Street, Box 357475, Seattle, WA 98195, USA. FAU - MacLachlan, Ellen AU - MacLachlan E AD - Department of Oral Health Sciences, University of Washington School of Dentistry, 1959 NE Pacific Street, Box 357475, Seattle, WA 98195, USA. LA - eng SI - ClinicalTrials.gov/NCT05219448 GR - R01 DE026741/DE/NIDCR NIH HHS/United States GR - R56 DE025813/DE/NIDCR NIH HHS/United States GR - U01 DE027629/DE/NIDCR NIH HHS/United States PT - Clinical Trial Protocol PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20241101 PL - United States TA - Contemp Clin Trials JT - Contemporary clinical trials JID - 101242342 RN - 0 (Dietary Sugars) SB - IM MH - Humans MH - Child MH - *Alaska Natives MH - Alaska MH - Child, Preschool MH - *Sugar-Sweetened Beverages MH - Infant MH - Female MH - Male MH - Dietary Sugars/administration & dosage MH - Health Promotion/methods PMC - PMC11633659 MID - NIHMS2034113 OTO - NOTNLM OT - Added sugar OT - Artificial sweeteners OT - Health inequities OT - Indigenous populations OT - Oral health behaviors OT - Oral health disparities OT - Sugar-sweetened beverages COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/11/04 00:31 MHDA- 2024/12/05 05:31 PMCR- 2025/12/01 CRDT- 2024/11/03 19:23 PHST- 2024/07/23 00:00 [received] PHST- 2024/10/18 00:00 [revised] PHST- 2024/10/30 00:00 [accepted] PHST- 2024/12/05 05:31 [medline] PHST- 2024/11/04 00:31 [pubmed] PHST- 2024/11/03 19:23 [entrez] PHST- 2025/12/01 00:00 [pmc-release] AID - S1551-7144(24)00317-3 [pii] AID - 10.1016/j.cct.2024.107734 [doi] PST - ppublish SO - Contemp Clin Trials. 2024 Dec;147:107734. doi: 10.1016/j.cct.2024.107734. Epub 2024 Nov 1. PMID- 39489345 OWN - NLM STAT- MEDLINE DCOM- 20241130 LR - 20260718 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 204 DP - 2025 Jan 1 TI - The bioSocial Cognitive Theory of eating (bSCT-e): Applying and elaborating on a biopsychosocial substance use theory for food addiction. PG - 107750 LID - S0195-6663(24)00554-3 [pii] LID - 10.1016/j.appet.2024.107750 [doi] AB - Obesity rates are increasing globally, and food addiction (FA(1)) may be an important contributing factor but there is a lack of understanding of the key psychological mechanisms that contribute to FA. The bioSocial Cognitive Theory (bSCT) proposes that substance use is predicted by biologically based personality traits and their influence on social cognitive mechanisms. While validated in substance use, bSCT has not been applied to a behavioural or non-substance addiction. However, the bSCT does not include a negative affective personality component, of which there is clear theoretical and empirical support as risk factors for FA. Thus, this study sought to test both the original bSCT model and an elaborated version related to eating (bSCT-e) that included direct and indirect punishment sensitivity pathways to identify the individual risk factors of FA. Data were collected from 204 university students (75.5% female; M(age) = 24.82, SD = 9.17) via an online survey. Both original bSCT and bSCT-e models provided a good fit to the data, with the latter providing slightly better fit and accounting for more variance in FA. The findings suggest that individuals who are more reward driven and punishment sensitive hold exaggerated beliefs about the reinforcing and emotion regulation effects of eating, which may undermine eating control and increase risk of FA. This study provides potential new insights into the complex biopsychosocial mechanisms of FA, and points to potential intervention targets. CI - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Zaphir, Jasmine S AU - Zaphir JS AD - School of Applied Psychology, Griffith University, Queensland, 4122, Australia. Electronic address: jasmine.zaphir@griffithuni.edu.au. FAU - Loxton, Natalie J AU - Loxton NJ AD - School of Applied Psychology, Griffith University, Queensland, 4122, Australia. Electronic address: n.loxton@griffith.edu.au. FAU - Gullo, Matthew J AU - Gullo MJ AD - School of Applied Psychology, Griffith University, Queensland, 4122, Australia. Electronic address: m.gullo@griffith.edu.au. LA - eng PT - Journal Article DEP - 20241101 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - *Food Addiction/psychology MH - Female MH - Male MH - Adult MH - Young Adult MH - Punishment/psychology MH - Reward MH - Cognition MH - Personality MH - Adolescent MH - Feeding Behavior/psychology MH - Surveys and Questionnaires MH - Eating/psychology MH - Risk Factors MH - Students/psychology MH - Models, Biopsychosocial MH - Substance-Related Disorders/psychology MH - Emotional Regulation OTO - NOTNLM OT - Behavioural approach system (BAS) OT - Behavioural inhibition system (BIS) OT - Expectancies OT - Food addiction OT - Impulsivity OT - Self-efficacy COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: There is a conflict of interest as one co-author for the manuscript "The bioSocial Cognitive Theory of Eating (bSCT-e): Applying and Elaborating on a Biopsychosocial Substance Use Theory for Food Addiction" is also an executive editor for Appetite. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/11/04 00:31 MHDA- 2024/12/01 15:22 CRDT- 2024/11/03 19:22 PHST- 2024/08/08 00:00 [received] PHST- 2024/10/17 00:00 [revised] PHST- 2024/10/30 00:00 [accepted] PHST- 2024/12/01 15:22 [medline] PHST- 2024/11/04 00:31 [pubmed] PHST- 2024/11/03 19:22 [entrez] AID - S0195-6663(24)00554-3 [pii] AID - 10.1016/j.appet.2024.107750 [doi] PST - ppublish SO - Appetite. 2025 Jan 1;204:107750. doi: 10.1016/j.appet.2024.107750. Epub 2024 Nov 1. PMID- 39487473 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241104 IS - 1744-859X (Print) IS - 1744-859X (Electronic) IS - 1744-859X (Linking) VI - 23 IP - 1 DP - 2024 Nov 1 TI - Assessing suicidality in adult ADHD patients: prevalence and related factors : Suicidality in adult ADHD patients. PG - 42 LID - 10.1186/s12991-024-00528-8 [doi] LID - 42 AB - BACKGROUND: The association between Attention-deficit hyperactivity disorder (ADHD) and suicidality has been subject of growing interest for research in the latest years. Suicidality was generally assessed categorically and without the use of validated instruments, leading to heterogeneous or even conflicting evidence. The prevalence of both suicidal ideation and attempts varies considerably, and the associated risk factors remain unclear. Our study investigated suicidality in ADHD using a dimensional approach and a validated and internationally recognized instrument. Our primary aim was to evaluate the prevalence of suicidal ideation (SI), severe suicidal ideation (SSI), suicidal behavior (SB) and non suicidal self-injury behavior (NSSIB) in a sample of adult patients with ADHD. The second objective was to identify sociodemographic and clinical features associated with increased risk of suicidality in these patients. METHODS: The sample included 74 adult patients with clinical diagnosis of ADHD. Suicidality was assessed by administering the Columbia-Suicide Severity Rating Scale. Logistic regressions were used to examine predictors of SI, SSI, SB and NSSIB. RESULTS: The lifetime prevalence of SI and SSI were 59.5% and 16.2%, respectively. The 9.5% of patients showed lifetime SB, while NSSIB was found in 10.8% of the subjects. Lifetime SI was associated with severity of inattentive symptoms during adulthood, low self-esteem and impairment in social functioning. Lifetime SSI appeared related to severity of inattentive symptoms during childhood, attentional impulsiveness and number of hospitalizations, while physical activity appeared to be protective. The prevalence of lifetime SB and NSSIB did not appear significantly related to any socio-demographic or clinical feature. CONCLUSIONS: Adults with ADHD should be considered at risk of suicide and it is important to determine which patients are at higher risk, in order to guide preventive interventions. The association between ADHD and suicidal ideation did not appear to be influenced by psychiatric comorbidities, but rather by inattention itself, which represents the core symptom of ADHD. CI - (c) 2024. The Author(s). FAU - Di Salvo, Gabriele AU - Di Salvo G AD - Department of Neurosciences "Rita Levi Montalcini", University of Turin, Turin, Italy. AD - Psychiatric Unit, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy. FAU - Perotti, Camilla AU - Perotti C AD - Department of Neurosciences "Rita Levi Montalcini", University of Turin, Turin, Italy. FAU - Filippo, Lorenzo AU - Filippo L AD - Department of Neurosciences "Rita Levi Montalcini", University of Turin, Turin, Italy. FAU - Garrone, Camilla AU - Garrone C AD - Department of Neurosciences "Rita Levi Montalcini", University of Turin, Turin, Italy. FAU - Rosso, Gianluca AU - Rosso G AD - Department of Neurosciences "Rita Levi Montalcini", University of Turin, Turin, Italy. gianluca.rosso@unito.it. AD - Psychiatric Unit, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy. gianluca.rosso@unito.it. FAU - Maina, Giuseppe AU - Maina G AD - Department of Neurosciences "Rita Levi Montalcini", University of Turin, Turin, Italy. AD - Psychiatric Unit, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy. LA - eng PT - Journal Article DEP - 20241101 PL - England TA - Ann Gen Psychiatry JT - Annals of general psychiatry JID - 101236515 PMC - PMC11531106 OTO - NOTNLM OT - Attention-deficit hyperactivity disorder OT - Risk factors OT - Suicidal behavior OT - Suicidal ideation OT - Suicide attempts COIS- All authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Gianluca Rosso has been a speaker and/or consultant from Angelini, Lundbeck, Janssen and Otsuka outside of the current work. Giuseppe Maina has been a consultant/speaker and/or has received research grants from Angelini, Boheringer, Innovapharma, Janssen, Fb Health, Otsuka, Lundbeck, Italfarmaco and Sanofi. Gabriele Di Salvo has been a speaker for Lundbeck and Angelini. Nevertheless, all authors report that this did not result in conflicts of interest for the present study. The authors declare no competing interests. EDAT- 2024/11/04 07:23 MHDA- 2024/11/04 07:24 PMCR- 2024/11/01 CRDT- 2024/11/02 00:43 PHST- 2024/06/25 00:00 [received] PHST- 2024/10/20 00:00 [accepted] PHST- 2024/11/04 07:24 [medline] PHST- 2024/11/04 07:23 [pubmed] PHST- 2024/11/02 00:43 [entrez] PHST- 2024/11/01 00:00 [pmc-release] AID - 10.1186/s12991-024-00528-8 [pii] AID - 528 [pii] AID - 10.1186/s12991-024-00528-8 [doi] PST - epublish SO - Ann Gen Psychiatry. 2024 Nov 1;23(1):42. doi: 10.1186/s12991-024-00528-8. PMID- 39484344 OWN - NLM STAT- MEDLINE DCOM- 20241101 LR - 20241107 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 12 DP - 2024 TI - Associations between antimony exposure and glycated hemoglobin levels in adolescents aged 12-19 years: results from the NHANES 2013-2016. PG - 1439034 LID - 10.3389/fpubh.2024.1439034 [doi] LID - 1439034 AB - OBJECTIVE: This study aimed to investigate the association between antimony (Sb) exposure and glycated hemoglobin (HbA1c) levels in adolescents. METHODS: A cross-sectional study of 751 adolescents aged 12-19 years was conducted via the National Health and Nutrition Examination Survey (NHANES, 2013-2016). Survey-weighted linear regression and restricted cubic spline (RCS) analyses were applied to evaluate the relationship of urinary Sb exposure with HbA1c. RESULTS: A significant relationship was observed between urinary Sb concentrations and HbA1c levels (percent change: 0.93; 95% CI: 0.42, 1.45) after full adjustment. After converting urinary Sb levels to a categorical variable by tertiles (T1-T3), the highest quantile was associated with a significant increase in HbA1c (percent change: 1.45; 95% CI: 0.38, 2.53) compared to T1. The RCS models showed a monotonically increasing relationship of urinary Sb with HbA1c. Subgroup analyses revealed a sex-specific relationship between urinary Sb exposure and HbA1c with a significant positive association in males and a non-significant positive association in females. Sensitivity analyses further confirmed the relationship between urinary Sb and HbA1c, even after excluding participants who were overweight or obese (percent change: 1.58%, 95% CI: 0.88, 2.28) and those with serum cotinine levels >/= 1 ng/mL (percent change: 1.14%, 95% CI: 0.49, 1.80). CONCLUSION: Our findings indicated that increased Sb exposure may correlate with higher HbA1c levels, especially in male adolescents. More studies are needed to further explore and validate the potential mechanisms. CI - Copyright (c) 2024 Feng, Tang, He, Peng, Mo, Zhu and Wei. FAU - Feng, Baoying AU - Feng B AD - Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. AD - Birth Defects Research Laboratory, Birth Defects Prevention and Control Institute of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. AD - Guangxi Clinical Research Center for Pediatric Disease, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. FAU - Tang, Peng AU - Tang P AD - Department of Epidemiology, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China. FAU - He, Sheng AU - He S AD - Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. AD - Birth Defects Research Laboratory, Birth Defects Prevention and Control Institute of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. AD - Guangxi Clinical Research Center for Pediatric Disease, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. AD - Birth Defects Research Laboratory, Guangxi Key Laboratory of Reproductive Health and Birth Defect Prevention, Nanning, Guangxi, China. FAU - Peng, Zhenren AU - Peng Z AD - Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. AD - Birth Defects Research Laboratory, Birth Defects Prevention and Control Institute of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. AD - Guangxi Clinical Research Center for Pediatric Disease, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. AD - Birth Defects Research Laboratory, Guangxi Key Laboratory of Reproductive Health and Birth Defect Prevention, Nanning, Guangxi, China. FAU - Mo, Yan AU - Mo Y AD - Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. AD - Birth Defects Research Laboratory, Birth Defects Prevention and Control Institute of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. AD - Guangxi Clinical Research Center for Pediatric Disease, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. FAU - Zhu, Liqiong AU - Zhu L AD - Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. FAU - Wei, Qiufen AU - Wei Q AD - Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. AD - Birth Defects Research Laboratory, Birth Defects Prevention and Control Institute of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. AD - Guangxi Clinical Research Center for Pediatric Disease, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. LA - eng PT - Journal Article DEP - 20241017 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - 9IT35J3UV3 (Antimony) RN - 0 (Glycated Hemoglobin) SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - Cross-Sectional Studies MH - *Antimony/blood MH - *Nutrition Surveys MH - *Glycated Hemoglobin/analysis MH - Child MH - Young Adult MH - Environmental Exposure/statistics & numerical data MH - United States PMC - PMC11524935 OTO - NOTNLM OT - National Health and Nutrition Examination Survey (NHANES) OT - adolescents OT - antimony OT - glycated hemoglobin OT - heavy metals COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/11/04 07:23 MHDA- 2024/11/04 12:24 PMCR- 2024/10/17 CRDT- 2024/11/01 05:12 PHST- 2024/05/27 00:00 [received] PHST- 2024/09/30 00:00 [accepted] PHST- 2024/11/04 12:24 [medline] PHST- 2024/11/04 07:23 [pubmed] PHST- 2024/11/01 05:12 [entrez] PHST- 2024/10/17 00:00 [pmc-release] AID - 10.3389/fpubh.2024.1439034 [doi] PST - epublish SO - Front Public Health. 2024 Oct 17;12:1439034. doi: 10.3389/fpubh.2024.1439034. eCollection 2024. PMID- 39482763 OWN - NLM STAT- MEDLINE DCOM- 20241101 LR - 20260521 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 23 IP - 1 DP - 2024 Nov 1 TI - Development of the two-factor modified Kids Eating Disorder Survey (M-KEDS): a validation study with hispanic adolescents. PG - 134 LID - 10.1186/s12937-024-01031-2 [doi] LID - 134 AB - BACKGROUND: Disordered eating behaviors and body dissatisfaction are highly prevalent among adolescents and linked to negative health outcomes. While Hispanic adolescents appear to be at high risk of disordered eating and body dissatisfaction, validated tools for assessment of these health concerns among this population are lacking. METHODS: This study used Confirmatory Factor Analysis to establish factorial validity for the Kids Eating Disorder Survey (KEDS) among a community sample of Hispanic adolescents. Internal consistency was measured by the Kuder-Richardson Formula 20 (KR-20). RESULTS: Participants (N = 690) were Hispanic (100%) and female (53%), with a mean age of 12 years. After testing the psychometric properties of KEDS and implementing modifications, the resulting two-factor KEDS model (M-KEDS) showed acceptable fit (TLI = 0.98, CFI = 0.99, RMSEA = 0.06) for the Weight Dissatisfaction (renamed to Negative Weight Attitudes) and Purging/Restriction (renamed to Extreme Weight Control Behaviors) sub-scales and good internal consistency (KR-20 = 0.77). CONCLUSION: M-KEDS is a factorial valid instrument for assessing Extreme Weight Control Behaviors and Negative Weight Attitudes among Hispanic adolescents. Hispanics are among the fastest-growing racial/ethnic groups in the United States, warranting further research on negative weight attitudes and extreme weight control behaviors in this population. CI - (c) 2024. The Author(s). FAU - Lopez, Tabbetha D AU - Lopez TD AD - Department of Human Sciences, Sam Houston State University, 1700 University Blvd., Huntsville, TX, 77340, USA. tdl030@shsu.edu. FAU - Cepni, Aliye B AU - Cepni AB AD - Department of Health and Human Performance, University of Houston, 3875 Holman St. Rm 104 Garrison, Houston, TX, 77204-6015, USA. FAU - Goodman, Lenora P AU - Goodman LP AD - Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 300 West Bank Office Building, 1300 S. 2nd St, Minneapolis, MN, 55454, USA. FAU - Arlinghaus, Katherine R AU - Arlinghaus KR AD - Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 300 West Bank Office Building, 1300 S. 2nd St, Minneapolis, MN, 55454, USA. FAU - Wiesner, Margit AU - Wiesner M AD - Department of Psychological, Health, and Learning Sciences, University of Houston, Stephen Power Farish Hall, 3657 Cullen Blvd., Room 491, Houston, TX, 77204-5023, USA. FAU - Johnston, Craig A AU - Johnston CA AD - Department of Health and Human Performance, University of Houston, 3875 Holman St. Rm 104 Garrison, Houston, TX, 77204-6015, USA. FAU - Haubrick, Kevin AU - Haubrick K AD - Department of Health and Human Performance, University of Houston, 3875 Holman St. Rm 104 Garrison, Houston, TX, 77204-6015, USA. FAU - Ledoux, Tracey A AU - Ledoux TA AD - Department of Health and Human Performance, University of Houston, 3875 Holman St. Rm 104 Garrison, Houston, TX, 77204-6015, USA. LA - eng GR - KL2 TR002492/TR/NCATS NIH HHS/United States GR - UL1 TR002494/TR/NCATS NIH HHS/United States GR - T32 DK083250/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Validation Study DEP - 20241101 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Body Dissatisfaction/psychology MH - Body Image/psychology MH - Body Weight MH - Factor Analysis, Statistical MH - *Feeding and Eating Disorders/ethnology/psychology MH - Feeding Behavior/psychology MH - *Hispanic or Latino/psychology MH - *Psychometrics/methods MH - Reproducibility of Results MH - Surveys and Questionnaires PMC - PMC11529255 COIS- The authors declare no competing interests. EDAT- 2024/11/04 04:19 MHDA- 2024/11/04 06:22 PMCR- 2024/11/01 CRDT- 2024/11/01 00:42 PHST- 2024/01/19 00:00 [received] PHST- 2024/10/09 00:00 [accepted] PHST- 2024/11/04 06:22 [medline] PHST- 2024/11/04 04:19 [pubmed] PHST- 2024/11/01 00:42 [entrez] PHST- 2024/11/01 00:00 [pmc-release] AID - 10.1186/s12937-024-01031-2 [pii] AID - 1031 [pii] AID - 10.1186/s12937-024-01031-2 [doi] PST - epublish SO - Nutr J. 2024 Nov 1;23(1):134. doi: 10.1186/s12937-024-01031-2. PMID- 39488501 OWN - NLM STAT- MEDLINE DCOM- 20241114 LR - 20241114 IS - 1466-447X (Electronic) IS - 0264-0414 (Linking) VI - 42 IP - 21 DP - 2024 Nov TI - Determinants of physical activities in settings (DE-PASS): Approach for selecting the core measures for determinants of physical activity behaviours in 9-12 old children. PG - 2021-2028 LID - 10.1080/02640414.2024.2422200 [doi] AB - In large transdisciplinary research teams finding the balance between using the most appropriate and needed measures for data collection and minimising participant burden is often a significant challenge. This paper aims to describe the development process for selecting a set of determinants of physical activity behaviours in 9-12 years old children. An internal small group (n = 8) worked iteratively with an external large group of experts and stakeholders (n = 30-50) in three steps: 1) External input - Identification through expert opinion; 2) Internal input - Identification and selection via a systematized approach; 3) External validation of the selected measures. During these steps, 113 measures were first identified, then scored, sorted, and selected using evidence-building practices such as systematic literature reviews, peer-review, and consensus discussions. Eighteen measures were agreed and included in the core measures toolkit (child and caregiver questionnaires). In conclusion, pragmatism, implementation concerns, and the experts' experience were key in this process. This process may be considered as a reference to others involved in the challenge of selecting measures in their research. FAU - Palmeira, A L AU - Palmeira AL AUID- ORCID: 0000-0001-6508-0599 AD - CIDEFES, Universidade Lusofona, Lisbon, Portugal. AD - CIFI2D, Faculty of Sport, University of Porto, Porto, Portugal. FAU - Jelsma, J G M AU - Jelsma JGM AUID- ORCID: 0000-0001-7943-9160 AD - Department of Public and Occupational Health, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. AD - Health Behaviors & Chronic Diseases, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands. FAU - Sousa-Sa, E AU - Sousa-Sa E AUID- ORCID: 0000-0001-8753-6817 AD - CIDEFES, Universidade Lusofona, Lisbon, Portugal. FAU - Pereira, S AU - Pereira S AUID- ORCID: 0000-0002-4661-3879 AD - CIDEFES, Universidade Lusofona, Lisbon, Portugal. AD - CIFI2D, Faculty of Sport, University of Porto, Porto, Portugal. FAU - Videira-Silva, A AU - Videira-Silva A AUID- ORCID: 0000-0002-8209-1676 AD - CIDEFES, Universidade Lusofona, Lisbon, Portugal. FAU - Condello, G AU - Condello G AUID- ORCID: 0000-0001-5092-3258 AD - Department of Medicine and Surgery, University of Parma, Parma, Italy. FAU - MacDonncha, C AU - MacDonncha C AD - Department of Physical Education and Sport Sciences and Health Research Institute, University of Limerick, Limerick, Ireland. FAU - Ribeiro, J C AU - Ribeiro JC AUID- ORCID: 0000-0001-6628-4606 AD - Research Center in Physical Activity Health and Leisure (CIAFEL); Faculty of Sport, University of Porto, Porto, Portugal. AD - Laboratory for Integrative and Translational Research in Population Health (ITR), Porto, Portugal. FAU - Gebremariam, M K AU - Gebremariam MK AUID- ORCID: 0000-0002-2626-2346 AD - Department of Community Medicine and Global Health, Institute of Health and Society, University of Oslo, Oslo, Norway. LA - eng PT - Journal Article DEP - 20241102 PL - England TA - J Sports Sci JT - Journal of sports sciences JID - 8405364 SB - IM MH - Humans MH - Child MH - *Exercise MH - Surveys and Questionnaires MH - Research Design MH - Health Behavior MH - Consensus MH - Data Collection/methods OTO - NOTNLM OT - Harmonization OT - Physical activity OT - determinants OT - measurement EDAT- 2024/11/03 00:40 MHDA- 2024/11/14 17:34 CRDT- 2024/11/02 23:43 PHST- 2024/11/14 17:34 [medline] PHST- 2024/11/03 00:40 [pubmed] PHST- 2024/11/02 23:43 [entrez] AID - 10.1080/02640414.2024.2422200 [doi] PST - ppublish SO - J Sports Sci. 2024 Nov;42(21):2021-2028. doi: 10.1080/02640414.2024.2422200. Epub 2024 Nov 2. PMID- 39486390 OWN - NLM STAT- MEDLINE DCOM- 20241130 LR - 20250605 IS - 1878-9307 (Electronic) IS - 1878-9293 (Print) IS - 1878-9293 (Linking) VI - 70 DP - 2024 Dec TI - A four-factor model of executive function: Predicting physical and academic outcomes from cognitive assessments in adolescents. PG - 101471 LID - S1878-9293(24)00132-4 [pii] LID - 10.1016/j.dcn.2024.101471 [doi] LID - 101471 AB - Impulsivity and cognitive function are essential for understanding behavioral regulation, particularly in relation to health-risk behaviors like substance use, physical activity, and academic performance. This study examined the factor structure underlying executive function in adolescents using the UPPS-P Impulsive Behavior Scale and NIH Toolbox Cognition Battery. We explored how parental monitoring moderates, and peer network health and perceived stress mediate, relationships between cognitive function and outcomes such as BMI, physical activity, and academic performance. Exploratory factor analysis (EFA) on 2228 observations identified a four-factor model (BIC = -97.92, RMSEA = 0.040, TLI = 0.936), validated by confirmatory factor analysis (CFA) (CFI = 0.961, RMSEA = 0.055). Structural equation modeling (SEM) on 5902 observations showed that parental monitoring moderated Factor 1 (adaptive impulsivity) in relation to physical activity and academic performance, while peer network health mediated Factor 2 (emotional impulsivity) effects on BMI and physical activity. This model underscores the influence of peer relationships, parental involvement, and stress on cognitive, health, and academic outcomes, suggesting that interventions enhancing peer support, reducing stress, and promoting healthy behaviors may improve adolescent well-being. CI - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Meruelo, Alejandro D AU - Meruelo AD AD - University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA. Electronic address: ameruelo@health.ucsd.edu. FAU - Gunawan, Tommy AU - Gunawan T AD - Human Psychopharmacology Laboratory and Office of Clinical Director, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20817 USA. Electronic address: tommy.gunawan@nih.gov. FAU - Thomas, Michael L AU - Thomas ML AD - Colorado State University, 1876 Campus Delivery, Fort Collins, CO 80523-1876, USA. Electronic address: Michael.L.Thomas@colostate.edu. FAU - Ramchandani, Vijay A AU - Ramchandani VA AD - Human Psychopharmacology Laboratory, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20817, USA. Electronic address: vijayr@mail.nih.gov. LA - eng GR - K23 AA026869/AA/NIAAA NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20241030 PL - Netherlands TA - Dev Cogn Neurosci JT - Developmental cognitive neuroscience JID - 101541838 SB - IM MH - Humans MH - Adolescent MH - *Executive Function/physiology MH - Female MH - Male MH - *Academic Performance MH - *Exercise/physiology/psychology MH - Impulsive Behavior/physiology MH - Cognition/physiology MH - Factor Analysis, Statistical MH - Peer Group MH - Body Mass Index MH - Adolescent Behavior/physiology/psychology MH - Stress, Psychological/psychology PMC - PMC11566708 OTO - NOTNLM OT - Academic performance OT - Body-mass index OT - Cognition OT - Confirmatory factor analysis OT - Impulsivity OT - Physical activity COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/11/02 23:13 MHDA- 2024/12/01 15:22 PMCR- 2024/10/30 CRDT- 2024/11/01 19:09 PHST- 2024/10/28 00:00 [received] PHST- 2024/10/28 00:00 [accepted] PHST- 2024/12/01 15:22 [medline] PHST- 2024/11/02 23:13 [pubmed] PHST- 2024/11/01 19:09 [entrez] PHST- 2024/10/30 00:00 [pmc-release] AID - S1878-9293(24)00132-4 [pii] AID - 101471 [pii] AID - 10.1016/j.dcn.2024.101471 [doi] PST - ppublish SO - Dev Cogn Neurosci. 2024 Dec;70:101471. doi: 10.1016/j.dcn.2024.101471. Epub 2024 Oct 30. PMID- 39476059 OWN - NLM STAT- MEDLINE DCOM- 20241030 LR - 20241101 IS - 1984-0462 (Electronic) IS - 0103-0582 (Print) IS - 0103-0582 (Linking) VI - 43 DP - 2024 TI - Analysis of heart rate as a predictor of changes in heart rate variability in children. PG - e2024045 LID - S0103-05822025000100413 [pii] LID - 10.1590/1984-0462/2025/43/2024045 [doi] LID - e2024045 AB - OBJECTIVE: To evaluate the predictive validity and cut-off point of heart rate and blood pressure on heart rate variability (HRV) changes in children with and without obesity. METHODS: This study included 125 children, of whom 41 were normal weight and 84 were obese. Anthropometry, blood pressure, heart rate, and HRV were measured using an electronic scale and stadiometer, a sphygmomanometer, and HRV monitor. In addition, the receiver operating characteristic (ROC) curve was obtained by statistical analysis of the data. RESULTS: Heart rate proved to be a good predictor for changes in the square root of the mean of the square of the differences between consecutive NN intervals (RMSSD) parameter in students of both sexes for the normal-weight group (ROC 0.89; 95%CI 0.77-1.00) and obesity (ROC 0.90; 95%CI 0.83-0.97). In addition, the heart rate cut-off point for alterations in the RMSSD parameter for normal-weight boys was 93 bpm (sensitivity 100.00% and specificity 87.50%) and for boys with obesity, the established cut-off point was 91 bpm (sensitivity 94.74% and specificity 63.64%). Heart rate also proved to be a good predictor considering low-frequency/high-frequency ratio (LF/HF) and standard deviation of long-term continuous NN intervals /standard deviation of the instantaneous variability of continuous NN intervals in the Poincare graph ratio (SD2/SD1). Systolic and diastolic blood pressures were good predictors in more specific stratifications and, therefore, can be used in some cases. CONCLUSIONS: The predictive validity of heart rate was shown to be at a good level, with high sensitivity and acceptable specificity for the cut-off points according to the different analyses stratified by gender and nutritional status. In this sense, health professionals will be able to use heart rate to estimate cardiovascular risk in children of different sexes and nutritional status. FAU - Costa, Paulo Cesar Trindade AU - Costa PCT AUID- ORCID: 0000-0003-3273-2399 AD - Universidade Federal da Paraiba, Joao Pessoa, PB, Brazil. FAU - Arruda Neta, Adelia da Costa Pereira de AU - Arruda Neta ADCP AUID- ORCID: 0000-0001-8271-3079 AD - Universidade Federal da Paraiba, Joao Pessoa, PB, Brazil. FAU - Martins, Vinicius Jose Baccin AU - Martins VJB AUID- ORCID: 0000-0002-0327-538X AD - Universidade Federal da Paraiba, Joao Pessoa, PB, Brazil. FAU - Alves, Jose Luiz de Brito AU - Alves JLB AUID- ORCID: 0000-0003-4696-3809 AD - Universidade Federal da Paraiba, Joao Pessoa, PB, Brazil. LA - eng PT - Journal Article DEP - 20241028 PL - Brazil TA - Rev Paul Pediatr JT - Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo JID - 9109353 SB - IM MH - Humans MH - *Heart Rate/physiology MH - Male MH - Female MH - Child MH - Predictive Value of Tests MH - Pediatric Obesity/physiopathology MH - Adolescent MH - Blood Pressure/physiology PMC - PMC11524575 COIS- Conflict of interests: The authors declare that there is no conflict of interests. EDAT- 2024/10/30 22:17 MHDA- 2024/10/31 04:54 PMCR- 2024/10/28 CRDT- 2024/10/30 16:29 PHST- 2024/02/28 00:00 [received] PHST- 2024/06/26 00:00 [accepted] PHST- 2024/10/31 04:54 [medline] PHST- 2024/10/30 22:17 [pubmed] PHST- 2024/10/30 16:29 [entrez] PHST- 2024/10/28 00:00 [pmc-release] AID - S0103-05822025000100413 [pii] AID - 10.1590/1984-0462/2025/43/2024045 [doi] PST - epublish SO - Rev Paul Pediatr. 2024 Oct 28;43:e2024045. doi: 10.1590/1984-0462/2025/43/2024045. eCollection 2024. PMID- 39472965 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241101 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 12 IP - 1 DP - 2024 Oct 29 TI - Addressing weight bias among pediatric healthcare clinical staff. PG - 170 LID - 10.1186/s40337-024-01123-8 [doi] LID - 170 AB - BACKGROUND: Children with obesity may experience weight-based discrimination as a result of weight bias and stigma, which can have deleterious effects on their health and wellbeing, including increased risk of dysregulated, maladaptive, and disordered eating such as restriction, purging, and binging. Prior work has shown that weight bias occurs from healthcare workers caring for adults, but less is known about the prevalence of weight bias in the pediatric healthcare setting. METHODS: We aimed to determine what proportion of pediatric healthcare professionals had attitudes of weight bias at our own institution by constructing a survey with questions from validated weight bias survey tools. Results revealed nearly half of all respondents had witnessed another healthcare professional make negative remarks about a patient with obesity, and many shared that they lacked the proper education/training and equipment to properly care for patients with obesity. Based on survey results, we created an electronic-based training module to educate healthcare professionals on weight bias and discrimination and how they may negatively affect care provided to children and families with obesity at our institution. Engagement with hospital leadership was a key strategy to ensure participation from medical and nursing/allied health staff in the survey, although only nursing/allied health leadership required the online training module resulting in limited physician engagement. RESULTS: Feedback received regarding the training module was overwhelmingly positive. CONCLUSIONS: Our efforts illustrate that weight bias and discrimination exist in pediatric institutions, and that participation in a tailored electronic-based training module may be viewed as a helpful tool to raise awareness of how weight-based discrimination and bias can negatively affect patient care. CI - (c) 2024. The Author(s). FAU - Kyler, Kathryn E AU - Kyler KE AD - Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO, 64108, USA. kekyler@cmh.edu. AD - University of Missouri-Kansas City, Kansas City, MO, USA. kekyler@cmh.edu. FAU - Cutburth, Codi AU - Cutburth C AD - Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO, 64108, USA. FAU - Goleman, Gayla AU - Goleman G AD - Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO, 64108, USA. FAU - Hampl, Sarah E AU - Hampl SE AD - Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO, 64108, USA. AD - University of Missouri-Kansas City, Kansas City, MO, USA. AD - Center for Children's Healthy Lifestyles & Nutrition, Kansas City, MO, USA. FAU - Beck, Amy R AU - Beck AR AD - Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO, 64108, USA. AD - University of Missouri-Kansas City, Kansas City, MO, USA. AD - Center for Children's Healthy Lifestyles & Nutrition, Kansas City, MO, USA. LA - eng PT - Journal Article DEP - 20241029 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC11523801 OAB - Weight bias and discrimination are present in pediatric healthcare settings and can lead to negative health effects for children with obesity, including increased risk of dysregulated, maladaptive, and disordered eating such as restriction, purging, and binging. Scientific studies on development of methods to address weight bias among child healthcare professionals is limited. In this article, we describe how we measured weight bias among clinical providers and staff in a large pediatric teaching hospital, and how this helped us obtain approval from hospital leaders to create training to help these child healthcare professionals understand the harmful effects of weight bias. OABL- eng OTO - NOTNLM OT - Discrimination OT - Obesity OT - Pediatric healthcare professionals OT - Stigma OT - Training module OT - Weight OT - Weight bias COIS- The authors have no competing interests relevant to the development of this manuscript. EDAT- 2024/10/30 10:28 MHDA- 2024/10/30 10:29 PMCR- 2024/10/29 CRDT- 2024/10/30 01:03 PHST- 2024/02/28 00:00 [received] PHST- 2024/10/03 00:00 [accepted] PHST- 2024/10/30 10:29 [medline] PHST- 2024/10/30 10:28 [pubmed] PHST- 2024/10/30 01:03 [entrez] PHST- 2024/10/29 00:00 [pmc-release] AID - 10.1186/s40337-024-01123-8 [pii] AID - 1123 [pii] AID - 10.1186/s40337-024-01123-8 [doi] PST - epublish SO - J Eat Disord. 2024 Oct 29;12(1):170. doi: 10.1186/s40337-024-01123-8. PMID- 39469806 OWN - NLM STAT- MEDLINE DCOM- 20241210 LR - 20250711 IS - 1447-0594 (Electronic) IS - 1447-0594 (Linking) VI - 24 IP - 12 DP - 2024 Dec TI - Association of sleep duration with obesity in older adults: A systematic review and meta-analysis. PG - 1269-1282 LID - 10.1111/ggi.15004 [doi] AB - BACKGROUND: Research on sleep duration and obesity is extensive in children and young individuals but limited and inconsistent for older adults. Our study aims to clarify the current status of this association in the elderly population. METHODS: We searched six English and four Chinese databases up to January 25, 2024, for observational studies on sleep duration and obesity in older adults. Two researchers independently conducted the literature search and data extraction. Study quality was assessed using the Newcastle-Ottawa Scale for cohort studies and the Agency for Healthcare Research and Quality for cross-sectional studies. Meta-analyses were performed using Stata 15.0 software, using both random-effects and fixed-effects models to calculate pooled odds ratios with 95% confidence intervals (CIs). RESULTS: The meta-analysis of 15 studies found a correlation between short sleep duration and obesity in older individuals (pooled odds ratio, 1.40 [95% CI: 1.12-1.73]; P = 0.003). However, no significant correlation was found between long sleep duration and obesity among the elderly (pooled odds ratio, 1.04 [95% CI, 0.95-1.13]; P = 0.426). CONCLUSIONS: Short sleep duration in the elderly was associated with obesity. More prospective studies need to be included in the future to improve the reliability of the conclusions. Geriatr Gerontol Int 2024; 24: 1269-1282. CI - (c) 2024 Japan Geriatrics Society. FAU - Jiang, Huan AU - Jiang H AD - School of Nursing, Chengdu University of Traditional Chinese Medicine, Chengdu, China. FAU - Zhang, Hanyu AU - Zhang H AD - School of Nursing, Chengdu University of Traditional Chinese Medicine, Chengdu, China. FAU - Wen, Zhifei AU - Wen Z AD - School of Nursing, Chengdu University of Traditional Chinese Medicine, Chengdu, China. FAU - Yuan, Jiang AU - Yuan J AD - School of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, China. FAU - Wang, Hongyan AU - Wang H AD - Sichuan Nursing Vocational College, Chengdu, China. FAU - Zhang, Xiangeng AU - Zhang X AUID- ORCID: 0000-0002-4611-6741 AD - Sichuan Nursing Vocational College, Chengdu, China. LA - eng GR - CJF23052/Sichuan Center for Education Development Research/ GR - 24SCLN150/Sichuan Gerontology Society/ GR - 2024ZRZ01/Sichuan Nursing Vocational College/ GR - H22009/Sichuan Nursing Association/ PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20241029 PL - Japan TA - Geriatr Gerontol Int JT - Geriatrics & gerontology international JID - 101135738 SB - IM MH - Humans MH - *Obesity/epidemiology MH - Aged MH - *Sleep/physiology MH - Time Factors MH - Male MH - Sleep Duration OTO - NOTNLM OT - elderly OT - meta-analysis OT - obesity OT - sleep duration OT - systematic review EDAT- 2024/10/29 06:23 MHDA- 2024/12/10 06:23 CRDT- 2024/10/29 05:33 PHST- 2024/09/11 00:00 [revised] PHST- 2024/06/28 00:00 [received] PHST- 2024/10/08 00:00 [accepted] PHST- 2024/12/10 06:23 [medline] PHST- 2024/10/29 06:23 [pubmed] PHST- 2024/10/29 05:33 [entrez] AID - 10.1111/ggi.15004 [doi] PST - ppublish SO - Geriatr Gerontol Int. 2024 Dec;24(12):1269-1282. doi: 10.1111/ggi.15004. Epub 2024 Oct 29. PMID- 39469773 OWN - NLM STAT- MEDLINE DCOM- 20241119 LR - 20241119 IS - 2152-2723 (Electronic) IS - 2152-2715 (Linking) VI - 27 IP - 11 DP - 2024 Nov TI - Does Socioeconomic Status Moderate the Association Between Screen Time, Mobile Phone Use, Social Networks, Messaging Applications, and Mental Health Among Adolescents? PG - 824-834 LID - 10.1089/cyber.2024.0064 [doi] AB - The aim of this study was to examine the relationship between different screen time (ST)-related behaviors and mental health conditions such as depression, anxiety, and stress. In addition, this study aimed to determine the moderating role of socioeconomic status (SES). This was a cross-sectional study and included data from 620 adolescents, aged 12-17 years, from the Valle de Ricote, Region of Murcia, Spain. Mental health was assessed using the Depression, Anxiety, and Stress Scale (DASS-21). Overall ST, mobile phone use, social network use, and messaging application use were measured using validated questionnaires. SES was assessed using the Family Affluence Scale-III. The results indicated that overall ST was significantly associated with symptoms of depression at the mean SES (unstandardized beta coefficient [B] = 0.005, p = 0.023) and 1 standard deviation (SD) below the mean (B = 0.007, p = 0.011), and with stress only 1 SD below the mean (B = 0.006, p = 0.011). No significant associations were found for anxiety and stress across all socioeconomic levels. Mobile phone use exhibited a strong positive association with symptoms of depression (B = 0.891, p < 0.001), anxiety (B = 0.530, p = 0.014), and stress (B = 0.790, p < 0.001) at 1 SD below the mean SES. Similar patterns were observed for mean SES, albeit with slightly weaker associations. Conversely, social network use was positively associated with all three DASS-21 scales, particularly at 1 SD below the mean SES, with the strongest associations found for symptoms of depression (B = 0.327, p < 0.001), anxiety (B = 0.325, p < 0.001), and stress (B = 0.318, p < 0.001). Furthermore, messaging application use did not show significant associations with symptoms of depression, anxiety, or stress across any SES levels. In conclusion, social inequalities may influence the associations between various ST-related behavior and symptoms of depression, anxiety, and stress among adolescents. These findings may have implications for the design of effective interventions to improve symptoms of depression, anxiety, and stress in this population. FAU - Visier-Alfonso, Maria Eugenia AU - Visier-Alfonso ME AUID- ORCID: 0000-0003-0364-8032 AD - Faculty of Nursing, Universidad de Castilla-La Mancha, Cuenca, Spain. AD - Health and Social Research Center, Universidad de Castilla-La Mancha, Cuenca, Spain. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AUID- ORCID: 0000-0002-7412-7624 AD - One Health Research Group, Universidad de Las Americas, Quito, Ecuador. FAU - Mesas, Arthur Eumann AU - Mesas AE AUID- ORCID: 0000-0002-0088-8607 AD - Faculty of Nursing, Universidad de Castilla-La Mancha, Cuenca, Spain. AD - Health and Social Research Center, Universidad de Castilla-La Mancha, Cuenca, Spain. FAU - Jimenez-Lopez, Estela AU - Jimenez-Lopez E AUID- ORCID: 0000-0001-8553-7701 AD - Faculty of Nursing, Universidad de Castilla-La Mancha, Cuenca, Spain. AD - Health and Social Research Center, Universidad de Castilla-La Mancha, Cuenca, Spain. AD - Department of Psychiatry, Hospital Virgen de la Luz, Cuenca, CIBERSAM, ISCIII, Madrid, Spain. FAU - Cekrezi, Shkelzen AU - Cekrezi S AUID- ORCID: 0009-0003-5016-3529 AD - Health and Social Research Center, Universidad de Castilla-La Mancha, Cuenca, Spain. FAU - Martinez-Vizcaino, Vicente AU - Martinez-Vizcaino V AUID- ORCID: 0000-0001-6121-7893 AD - Faculty of Nursing, Universidad de Castilla-La Mancha, Cuenca, Spain. AD - Health and Social Research Center, Universidad de Castilla-La Mancha, Cuenca, Spain. AD - Faculty of Medicine, Universidad Autonoma de Chile, Talca, Chile. LA - eng PT - Journal Article DEP - 20241029 PL - United States TA - Cyberpsychol Behav Soc Netw JT - Cyberpsychology, behavior and social networking JID - 101528721 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - Cross-Sectional Studies MH - *Social Class MH - *Depression/epidemiology/psychology MH - Child MH - *Mental Health/statistics & numerical data MH - *Social Networking MH - *Anxiety/epidemiology/psychology MH - *Screen Time MH - Cell Phone Use/statistics & numerical data MH - Spain/epidemiology MH - Stress, Psychological/psychology/epidemiology MH - Adolescent Behavior/psychology MH - Surveys and Questionnaires MH - Mobile Applications/statistics & numerical data MH - Text Messaging/statistics & numerical data OTO - NOTNLM OT - anxiety OT - depression OT - mobile phone use OT - social networks OT - socioeconomic status OT - stress EDAT- 2024/10/29 06:23 MHDA- 2024/11/19 22:19 CRDT- 2024/10/29 05:13 PHST- 2024/11/19 22:19 [medline] PHST- 2024/10/29 06:23 [pubmed] PHST- 2024/10/29 05:13 [entrez] AID - 10.1089/cyber.2024.0064 [doi] PST - ppublish SO - Cyberpsychol Behav Soc Netw. 2024 Nov;27(11):824-834. doi: 10.1089/cyber.2024.0064. Epub 2024 Oct 29. PMID- 39468697 OWN - NLM STAT- MEDLINE DCOM- 20250424 LR - 20250516 IS - 1099-0968 (Electronic) IS - 1072-4133 (Print) IS - 1072-4133 (Linking) VI - 33 IP - 2 DP - 2025 Mar TI - Impairments in personality functioning in adolescents with anorexia nervosa. PG - 360-373 LID - 10.1002/erv.3146 [doi] AB - OBJECTIVE: Impairments in personality functioning (PF) according to the Alternative Model of Personality Disorders (AMPD) may affect anorexia nervosa (AN) and its treatment. However, PF impairments in adolescents with AN have not been studied. This case-control study analysed PF impairments in adolescent inpatients suffering from AN compared to a clinical control group (CC) and investigated the relationship of PF with AN severity. METHOD: Adolescent patients with AN (n = 43) and CC (n = 127) were matched by age, sex, and global functioning. Validated interviews were applied to assess impairments in PF (Semi-Structured Interview for Personality Functioning, STiP-5.1) and severity of AN (Eating Disorder Examination, EDE), as well as weight measures. Group comparisons of PF impairment and the relationship between PF impairment and AN severity were analysed using multiple linear regression. RESULTS: AN patients showed greater impairment in the facet 'self-esteem' (p = 0.033, Cohen's f(2) = 0.036) than CC. In AN patients, impairments in the domain 'self-functioning' (p = 0.003, Cohen's f(2) = 0.254) and its underlying element 'identity' (p = 0.016, Cohen's f(2) = 0.172) were associated with AN severity (EDE). Additionally, higher impairments in two facets of 'empathy' (p = 0.019, Cohen's f(2) = 0.223) and 'intimacy' (p = 0.026, Cohen's f(2) = 0.199) were associated with higher AN severity (lower BMI percentiles). CONCLUSIONS: These results support theoretical frameworks of AN and highlight the importance of PF impairments in understanding and treating AN. Future research should investigate how impairments in PF affect AN development and treatment response through longitudinal studies. CI - (c) 2024 The Author(s). European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd. FAU - Schumacher, Andrea M AU - Schumacher AM AUID- ORCID: 0009-0005-0508-3583 AD - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland. FAU - Tschitsaz, Armita AU - Tschitsaz A AUID- ORCID: 0009-0009-4578-4949 AD - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland. FAU - Lerch, Stefan AU - Lerch S AUID- ORCID: 0000-0002-9578-6864 AD - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland. FAU - Wyssen, Andrea AU - Wyssen A AUID- ORCID: 0000-0003-0836-9817 AD - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland. FAU - Schlensog-Schuster, Franziska AU - Schlensog-Schuster F AUID- ORCID: 0000-0002-8033-6537 AD - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland. FAU - Murner-Lavanchy, Ines AU - Murner-Lavanchy I AUID- ORCID: 0000-0003-1127-3509 AD - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland. AD - Division of Youth Mental Health, Faculty of Psychology, University of Basel, Basel, Switzerland. FAU - Koenig, Julian AU - Koenig J AUID- ORCID: 0000-0003-1009-9625 AD - Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. FAU - Cavelti, Marialuisa AU - Cavelti M AUID- ORCID: 0000-0003-4726-396X AD - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland. FAU - Kaess, Michael AU - Kaess M AUID- ORCID: 0000-0003-0031-7764 AD - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland. AD - Department of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany. LA - eng GR - University of Bern/ PT - Journal Article DEP - 20241028 PL - England TA - Eur Eat Disord Rev JT - European eating disorders review : the journal of the Eating Disorders Association JID - 9436977 SB - IM MH - Humans MH - *Anorexia Nervosa/psychology/complications MH - Adolescent MH - Female MH - Case-Control Studies MH - *Personality Disorders/psychology/complications MH - *Self Concept MH - Male MH - Severity of Illness Index MH - *Personality PMC - PMC11786945 OTO - NOTNLM OT - adolescence OT - alternative model of personality disorder OT - eating disorder OT - personality disorder OT - personality functioning COIS- The authors declare no conflicts of interest. EDAT- 2024/10/29 06:23 MHDA- 2025/02/02 05:11 PMCR- 2025/02/01 CRDT- 2024/10/29 01:57 PHST- 2024/09/23 00:00 [revised] PHST- 2024/06/18 00:00 [received] PHST- 2024/10/15 00:00 [accepted] PHST- 2025/02/02 05:11 [medline] PHST- 2024/10/29 06:23 [pubmed] PHST- 2024/10/29 01:57 [entrez] PHST- 2025/02/01 00:00 [pmc-release] AID - ERV3146 [pii] AID - 10.1002/erv.3146 [doi] PST - ppublish SO - Eur Eat Disord Rev. 2025 Mar;33(2):360-373. doi: 10.1002/erv.3146. Epub 2024 Oct 28. PMID- 39467540 OWN - NLM STAT- MEDLINE DCOM- 20241218 LR - 20241218 IS - 1543-2742 (Electronic) IS - 1526-484X (Linking) VI - 35 IP - 1 DP - 2025 Jan 1 TI - Body Mass Management Practices of Olympic Weightlifting Athletes. PG - 67-75 LID - 10.1123/ijsnem.2024-0064 [doi] AB - This study explored the body mass (BM) management practices among competitive male and female Olympic weightlifting athletes, hypothesizing that athletes compete in lighter weight categories than their habitual training weight (i.e., making weight). Utilizing a validated, anonymous survey, data were collected from 149 Olympic weightlifting athletes (>18 years; female = 94). The survey comprised five sections: demographics, training/competition history, weight history, source of influence, and BM management practices. The prevalence, magnitude, and methods employed for BM management were analyzed with subgroup analysis using one-way analysis of variance. Post hoc testing including Spearman's rho and chi-square analysis was completed when a significant effect was found. Three quarters (76%) of athletes acknowledged using chronic weight loss and/or acute weight loss strategies to make weight. Usual BM loss (2%-3%) in the week before competition was within recommended guidelines. Gradual dieting, fluid restriction, and low food weight, high-calorie options were the most commonly used BM management strategies. Female athletes were more likely to use gradual dieting (p = .043; r = .104) and were less likely to increase their exercise (p = .046; r = -.105) and utilize fasting (p = .038; r = .05) compared with their male counterparts. Women further identified dietitians/nutritionists (p = .006; r = .022) as a highly influential source of information. This research offers new insights into the BM management practices of Olympic weightlifting athletes, identifying that the majority of athletes compete at a BM lighter than their habitual training weight, achieved using a range of chronic weight loss and acute weight loss strategies. FAU - Cox, Amie M AU - Cox AM AUID- ORCID: 0009-0009-2970-2923 AD - School of Health, University of the Sunshine Coast, Sunshine Coast, QLD, Australia. FAU - Langan-Evans, Carl AU - Langan-Evans C AUID- ORCID: 0000-0003-1120-6592 AD - School of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom. FAU - Jenkins, David AU - Jenkins D AUID- ORCID: 0000-0003-0596-9526 AD - School of Health, University of the Sunshine Coast, Sunshine Coast, QLD, Australia. AD - Applied Sports Science Technology and Medicine Research Centre, Swansea University, Wales, United Kingdom. FAU - Reale, Reid AU - Reale R AUID- ORCID: 0000-0002-2079-3971 AD - UFC Performance Institute, Shanghai, China. FAU - Pelly, Fiona AU - Pelly F AUID- ORCID: 0000-0002-4735-1807 AD - School of Health, University of the Sunshine Coast, Sunshine Coast, QLD, Australia. FAU - Slater, Gary J AU - Slater GJ AUID- ORCID: 0000-0003-2753-7847 AD - School of Health, University of the Sunshine Coast, Sunshine Coast, QLD, Australia. LA - eng PT - Journal Article DEP - 20241028 PL - United States TA - Int J Sport Nutr Exerc Metab JT - International journal of sport nutrition and exercise metabolism JID - 100939812 SB - IM MH - Humans MH - Female MH - Male MH - *Athletes MH - *Weight Lifting/physiology MH - Adult MH - *Weight Loss MH - Young Adult MH - Surveys and Questionnaires MH - Body Mass Index MH - Sports Nutritional Physiological Phenomena MH - Adolescent MH - Body Weight OTO - NOTNLM OT - rapid weight loss OT - strength-sport OT - weightlifters EDAT- 2024/10/29 00:22 MHDA- 2024/12/19 00:20 CRDT- 2024/10/28 19:32 PHST- 2024/03/30 00:00 [received] PHST- 2024/07/12 00:00 [revised] PHST- 2024/09/11 00:00 [accepted] PHST- 2024/12/19 00:20 [medline] PHST- 2024/10/29 00:22 [pubmed] PHST- 2024/10/28 19:32 [entrez] AID - 10.1123/ijsnem.2024-0064 [doi] PST - epublish SO - Int J Sport Nutr Exerc Metab. 2024 Oct 28;35(1):67-75. doi: 10.1123/ijsnem.2024-0064. Print 2025 Jan 1. PMID- 39467519 OWN - NLM STAT- MEDLINE DCOM- 20250204 LR - 20260602 IS - 1421-9697 (Electronic) IS - 0250-6807 (Linking) VI - 81 IP - 1 DP - 2025 TI - Validation of Fat Mass Metrics in Pediatric Obesity. PG - 12-21 LID - 10.1159/000542029 [doi] AB - INTRODUCTION: Hudda-Index is a prediction model for fat mass (FM) based on simple anthropometric measures. FM is a crucial factor in the development of comorbidities, i.e., type 2 diabetes. Hence, Hudda-Index is a promising tool to facilitate the identification of children at risk for metabolic comorbidities. It has been validated against deuterium dilution assessments; however, independent validation against the gold standard for body composition analysis, magnetic resonance imaging (MRI), is lacking. The aim of this study was to validate FM calculated by Hudda-Index against FM measured by MRI. The secondary aim was to compare Hudda-Index to other anthropometric measures including body mass index (BMI), BMI-standard deviation score (BMI-SDS), waist/hip-ratio, waist circumference (WC), and skinfold thickness. METHODS: The study cohort consists of 115 individuals between the age of 9 and 15 years, recruited at Paracelsus Medical University Hospital in Salzburg (Austria) and Uppsala University Children's Hospital (Sweden). Anthropometry, blood samples, and oral glucose tolerance tests followed standard procedures. MRI examinations were performed to determine visceral adipose tissue (VAT) and subcutaneous adipose tissue. RESULTS: BMI and WC showed slightly stronger associations with the reference standard VAT (r = 0.72 and 0.70, p < 0.01, respectively) than Hudda-Index (r = 0.67, p < 0.01). There is an almost perfect linear association between BMI and Hudda-Index. Accordingly, BMI and Hudda-Index both showed an acceptable association with cardiometabolic parameters. VAT was strongly associated with markers of liver status (LFF r = 0.59, p < 0.01) and insulin resistance (HOMA-IR r = 0.71, p < 0.01) and predicted metabolic dysfunction-associated steatotic liver disease. CONCLUSION: BMI, although an imperfect measure, remains the most reliable tool and estimates cardiometabolic risk more reliably than other anthropometry-based measures. CI - (c) 2024 S. Karger AG, Basel. FAU - Lischka, Julia AU - Lischka J AD - Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria, lischka.julia@gmail.com. AD - Obesity Research Unit, Paracelsus Medical University, Salzburg, Austria, lischka.julia@gmail.com. FAU - Pixner, Thomas AU - Pixner T AD - Obesity Research Unit, Paracelsus Medical University, Salzburg, Austria. AD - Department of Pediatric and Adolescent Medicine, Salzkammergutklinikum Voecklabruck, Voecklabruck, Austria. FAU - Morwald, Katharina AU - Morwald K AD - Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria. AD - Obesity Research Unit, Paracelsus Medical University, Salzburg, Austria. FAU - Lauth, Wanda AU - Lauth W AD - Team Biostatistics and Big Medical Data, IDA Lab Salzburg, Paracelsus Medical University, Salzburg, Austria. AD - Research Programme Biomedical Data Science, Paracelsus Medical University, Salzburg, Austria. FAU - Furthner, Dieter AU - Furthner D AD - Obesity Research Unit, Paracelsus Medical University, Salzburg, Austria. AD - Department of Pediatric and Adolescent Medicine, Salzkammergutklinikum Voecklabruck, Voecklabruck, Austria. FAU - Weghuber, Daniel AU - Weghuber D AD - Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria. AD - Obesity Research Unit, Paracelsus Medical University, Salzburg, Austria. FAU - Gomahr, Julian AU - Gomahr J AD - Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria. AD - Obesity Research Unit, Paracelsus Medical University, Salzburg, Austria. FAU - Thivel, David AU - Thivel D AD - Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions, Clermont Auvergne University, Clermont-Ferrand, France. FAU - Brandtner, Herwig AU - Brandtner H AD - Department of Radiology, Paracelsus Medical University of Salzburg, Salzburg, Austria. FAU - Bergauer, Max AU - Bergauer M AD - Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria. AD - Obesity Research Unit, Paracelsus Medical University, Salzburg, Austria. FAU - Forer, Lotte AU - Forer L AD - Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria. AD - Obesity Research Unit, Paracelsus Medical University, Salzburg, Austria. FAU - Torbahn, Gabriel AU - Torbahn G AD - Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria. AD - Obesity Research Unit, Paracelsus Medical University, Salzburg, Austria. AD - Department of Pediatrics, Paracelsus Medical University, Klinikum Nurnberg, Universitatsklinik der Paracelsus Medizinischen Privatuniversitat Nurnberg, Nuremberg, Germany. FAU - Forslund, Anders AU - Forslund A AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. FAU - Ciba, Iris AU - Ciba I AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. FAU - Manell, Hannes AU - Manell H AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. FAU - Kullberg, Joel AU - Kullberg J AD - Radiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden. AD - Antaros Medical, Molndal, Sweden. FAU - Anderwald, Christian-Heinz AU - Anderwald CH AD - Obesity Research Unit, Paracelsus Medical University, Salzburg, Austria. AD - Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria. AD - Direction, Arnoldstein Healthcare Centre, Arnoldstein, Austria. FAU - Bergsten, Peter AU - Bergsten P AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. AD - Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden. LA - eng PT - Journal Article PT - Validation Study DEP - 20241028 PL - Switzerland TA - Ann Nutr Metab JT - Annals of nutrition & metabolism JID - 8105511 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - *Pediatric Obesity MH - Body Mass Index MH - Adolescent MH - Magnetic Resonance Imaging MH - Waist Circumference MH - *Anthropometry/methods MH - Intra-Abdominal Fat/diagnostic imaging MH - Body Composition MH - Skinfold Thickness MH - Waist-Hip Ratio MH - Cohort Studies OTO - NOTNLM OT - Adipose tissue OT - BMI OT - Body composition OT - Hudda-Index OT - Magnetic resonance imaging EDAT- 2024/10/29 00:23 MHDA- 2025/02/05 00:19 CRDT- 2024/10/28 19:23 PHST- 2024/07/04 00:00 [received] PHST- 2024/10/04 00:00 [accepted] PHST- 2025/02/05 00:19 [medline] PHST- 2024/10/29 00:23 [pubmed] PHST- 2024/10/28 19:23 [entrez] AID - 000542029 [pii] AID - 10.1159/000542029 [doi] PST - ppublish SO - Ann Nutr Metab. 2025;81(1):12-21. doi: 10.1159/000542029. Epub 2024 Oct 28. PMID- 39467010 OWN - NLM STAT- MEDLINE DCOM- 20241204 LR - 20260724 IS - 1536-4801 (Electronic) IS - 0277-2116 (Print) IS - 0277-2116 (Linking) VI - 79 IP - 6 DP - 2024 Dec TI - Food insecurity impacts diet quality and adherence to the gluten-free diet in youth with celiac disease. PG - 1180-1191 LID - 10.1002/jpn3.12398 [doi] AB - OBJECTIVES: Celiac disease (CD) is an autoimmune gastrointestinal disorder that requires a strict lifelong gluten-free diet (GFD). Gluten-free (GF) foods are more expensive and less readily accessible than gluten-containing foods, contributing to an increased risk for food insecurity (FI). The study aimed to determine associations between GF-FI, sociodemographic risk factors and child dietary adherence and diet quality (DQ). METHODS: A 26-item, cross-country online survey was administered through social media to parents of children with CD on the GFD. The survey elicited household and CD child sociodemographic and clinical characteristics (e.g., duration of CD), measures of household FI, child DQ and GFD adherence, and parents' concerns related to GF food. Household GF-FI was evaluated using the validated Hunger Vital Sign and the US Department of Agriculture Six-Item Short Form Household Food Security Survey Module. RESULTS: GF-FI occurred in 47% of households with children with CD with >30% reporting low to very low food security. Sociodemographic risk factors identified included lower income, renters, rural residency, single-parental households, and having children with additional dietary restrictions (p < 0.001). Regardless of FI status, a majority of households reported experiencing significantly higher GF food expenditure. GF-FI was associated with reduced adherence to the GFD, increased consumption of processed GF food, and lower intakes of fresh fruits and vegetables and GF grains among children with CD (p < 0.05). CONCLUSIONS: GF-FI is prevalent in this multiethnic cohort of households with CD children and is associated with worsening DQ and GFD adherence. Policy interventions are urgently needed to address GF-FI. CI - (c) 2024 The Author(s). Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Wang, Xinyi AU - Wang X AD - Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Canada. FAU - Anders, Sven AU - Anders S AD - Department of Resource Economics and Environmental Sociology, University of Alberta, Edmonton, Canada. FAU - Jiang, Zhiqian AU - Jiang Z AD - Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Canada. FAU - Bruce, Marcia AU - Bruce M AD - Department of Medicine, University of Calgary, Calgary, Canada. FAU - Gidrewicz, Dominica AU - Gidrewicz D AD - Division of Pediatric Gastroenterology and Nutrition, University of Calgary, Calgary, Canada. FAU - Marcon, Margaret AU - Marcon M AD - Department of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Canada. FAU - Turner, Justine M AU - Turner JM AD - Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Canada. AD - Department of Pediatrics, University of Alberta, Edmonton, Canada. FAU - Mager, Diana R AU - Mager DR AUID- ORCID: 0000-0002-5558-8783 AD - Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Canada. AD - Department of Pediatrics, University of Alberta, Edmonton, Canada. LA - eng GR - Woman's Child and Health Research Institute (WCHRI) (Clinical/Community Research Integration Support Grant Program, University of Alberta)/ GR - Calgary Chapter of Celiac Canada (Graduate Student Funding)/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241028 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM MH - Humans MH - *Celiac Disease/diet therapy MH - *Diet, Gluten-Free/statistics & numerical data MH - Male MH - Female MH - Child MH - *Food Insecurity MH - Adolescent MH - *Patient Compliance/statistics & numerical data MH - Child, Preschool MH - Risk Factors MH - Surveys and Questionnaires MH - Cross-Sectional Studies MH - Diet/statistics & numerical data PMC - PMC11615129 OTO - NOTNLM OT - food security OT - gluten-free food OT - pediatric COIS- The authors declare no conflict of interest. EDAT- 2024/10/28 18:23 MHDA- 2024/12/04 06:22 PMCR- 2024/12/04 CRDT- 2024/10/28 14:33 PHST- 2024/09/13 00:00 [revised] PHST- 2024/06/19 00:00 [received] PHST- 2024/10/11 00:00 [accepted] PHST- 2024/12/04 06:22 [medline] PHST- 2024/10/28 18:23 [pubmed] PHST- 2024/10/28 14:33 [entrez] PHST- 2024/12/04 00:00 [pmc-release] AID - JPN312398 [pii] AID - 10.1002/jpn3.12398 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2024 Dec;79(6):1180-1191. doi: 10.1002/jpn3.12398. Epub 2024 Oct 28. PMID- 39466825 OWN - NLM STAT- MEDLINE DCOM- 20241028 LR - 20260917 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 10 DP - 2024 TI - Validity and reliability of a physical literacy knowledge, attitudes, self-efficacy and behaviors questionnaire for early childhood educators (PLKASB-ECE): An exploratory factor analysis. PG - e0312736 LID - 10.1371/journal.pone.0312736 [doi] LID - e0312736 AB - BACKGROUND: Nurturing physical literacy in young children offers a unique opportunity to address global physical inactivity trend. Early childhood education and care (ECEC) environments, with their extensive reach into this age group, and early childhood educators, through their daily interactions with children, are strategically positioned to influence children's physical literacy development. However, enhancing educators' ability to foster physical literacy requires valid and reliable assessment tools to measure holistic physical literacy constructs (i.e., cognitive, affective, behavioral) to assess the impact of physical literacy educational interventions. OBJECTIVE: The purpose of this study was to develop a holistic digital tool to measure physical literacy knowledge, attitudes, self-efficacy, and behaviors of early childhood educators (PLKASB-ECE) for both their professional teaching context as well as the educator's own personal physical literacy behaviours. METHODS: This study was conducted in two phases. Phase 1 involved item generation and content validation. Phase 2 employed a cross-sectional validation study design to assess the psychometric properties of the PLKASB-ECE tool. RESULTS: Based on a literature review an initial 19-item instrument was developed that subsequently underwent three rounds of expert content validation. Six additional items were added, resulting in a final 25-item self-report measure with a readability score equivalent to an 8th grade reading level (Flesch-Kincaid Grade Level: 8.7). This included 1 global rating item, 2 qualitative response items, 7 knowledge items, and 15 items addressing physical literacy attitudes, self-efficacy and behaviors using a 7-point Likert response scale. The PLKASB-ECE tool was administered to 470 educators in Alberta, Canada between 2019 to 2022. The 15 items were subjected to exploratory factor analysis and resulted in a five-factor scale with one item not loading. The five-factor scale held with the final 14 items with loadings ranging from 0.481 to 0.886, Cronbach's alpha ranging from 0.70 to 0.82, with ordinal omega ranging from 0.72 to 0.82. Usability, as assessed by completion time, was 8.15 minutes. CONCLUSION: These findings demonstrate good indices of reliability and validity for the PLKASB-ECE tool. This tool will be valuable as a research outcome measure for assessing educational interventions aimed at enhancing educators' understanding, confidence, and strategies for fostering holistic concepts of physical literacy in young children within ECECs. CI - Copyright: (c) 2024 Lafave et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Lafave, Lynne M Z AU - Lafave LMZ AUID- ORCID: 0000-0002-9781-3213 AD - Department Health and Physical Education, Department Health and Physical Education, CHEERS Lab, Mount Royal University, Calgary, Alberta, Canada. AD - Department Health and Physical Education, Mount Royal University, Calgary, Alberta, Canada. FAU - Van Wyk, Nadine AU - Van Wyk N AUID- ORCID: 0009-0009-4768-2014 AD - Department Health and Physical Education, Mount Royal University, Calgary, Alberta, Canada. FAU - Webster, Alexis D AU - Webster AD AUID- ORCID: 0000-0003-1557-9345 AD - Department Health and Physical Education, Department Health and Physical Education, CHEERS Lab, Mount Royal University, Calgary, Alberta, Canada. FAU - Hayek, Joyce AU - Hayek J AD - Department Health and Physical Education, Department Health and Physical Education, CHEERS Lab, Mount Royal University, Calgary, Alberta, Canada. FAU - Lafave, Mark R AU - Lafave MR AD - Department Health and Physical Education, Mount Royal University, Calgary, Alberta, Canada. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20241028 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Self Efficacy MH - Female MH - Surveys and Questionnaires MH - Male MH - *Health Knowledge, Attitudes, Practice MH - Factor Analysis, Statistical MH - Reproducibility of Results MH - Adult MH - Cross-Sectional Studies MH - Psychometrics/methods MH - Health Literacy MH - Child MH - Child, Preschool MH - Exercise PMC - PMC11516012 COIS- The authors have declared that no competing interests exist. EDAT- 2024/10/28 18:23 MHDA- 2024/10/28 18:24 PMCR- 2024/10/28 CRDT- 2024/10/28 13:44 PHST- 2024/03/03 00:00 [received] PHST- 2024/10/11 00:00 [accepted] PHST- 2024/10/28 18:24 [medline] PHST- 2024/10/28 18:23 [pubmed] PHST- 2024/10/28 13:44 [entrez] PHST- 2024/10/28 00:00 [pmc-release] AID - PONE-D-24-06642 [pii] AID - 10.1371/journal.pone.0312736 [doi] PST - epublish SO - PLoS One. 2024 Oct 28;19(10):e0312736. doi: 10.1371/journal.pone.0312736. eCollection 2024. PMID- 39466819 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241030 IS - 2767-3375 (Electronic) IS - 2767-3375 (Linking) VI - 4 IP - 10 DP - 2024 TI - Perinatal depression and adverse child growth outcomes in low-income and middle-income countries (LMICs): A systematic review and meta-analysis. PG - e0003586 LID - 10.1371/journal.pgph.0003586 [doi] LID - e0003586 AB - Perinatal depression (PND), which encompasses the antepartum and postpartum depression (APD and PPD), is a neglected crisis in low-income and middle-income countries (LMICs). We aimed to systematically search and meta-analyze existing evidence to determine whether a mother's PND affects adverse growth outcomes in children in LMICs (PROSPERO protocol: CRD42021246803). We conducted searches, including nine databases (PubMed, EMBASE, Web of Science, CINAHL Plus, Global Health Database, Google Scholar, WHO Regional Databases, PsycINFO, and LILACS) from January 2000 to September 2023. We restricted studies that assessed PND using validated screening tools or clinical interviews during pregnancy or within 12 months postpartum. We included studies that reported four types of adverse child growth outcomes (stunting, wasting, underweight, and overweight/obesity) in children younger than 5 years. We assessed the quality using the Newcastle Ottawa Scale and pooled risk ratios (RRs) and odds ratios (ORs) between PND and each adverse growth outcome using random-effects models. In total, 27 studies met the inclusion criteria for systematic review, with 24 eligible for meta-analysis, spanning data from 15 countries and 26,261 mother-baby pairs. Based on the studies that reported ORs, children below the age of 3 years with mothers experiencing PND had higher odds for stunting (OR 1.63, 95% CI 1.32, 2.02, I2 = 56.0%) and underweight (OR 2.65, 95% CI 1.90, 3.68, I2 = 34.5%) compared to children of mothers without PND. The pooled RRs for stunting and underweight did not show significant differences between mothers with and without PND. Studies on wasting (n = 5) and overweight/obesity (n = 2) were limited, demonstrating inconsistent results across studies. The association between PND and adverse growth outcomes varied according to the measure of association, region, country, PND type, outcome timepoint, and study design. There were limited studies in diverse LMICs, particularly on wasting, or overweight/obesity as an outcome. CI - Copyright: (c) 2024 Carosella et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Carosella, Elizabeth AU - Carosella E AUID- ORCID: 0000-0001-6166-9734 AD - Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America. FAU - Chhabria, Shradha AU - Chhabria S AD - Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America. FAU - Kim, Hyelee AU - Kim H AUID- ORCID: 0000-0001-5170-4057 AD - Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America. FAU - Moreira, Aliya AU - Moreira A AUID- ORCID: 0000-0001-8840-8075 AD - Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America. FAU - Naamani, Dana AU - Naamani D AD - Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America. FAU - Ninesling, Brennan AU - Ninesling B AD - Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America. FAU - Lansdale, Aimee AU - Lansdale A AUID- ORCID: 0000-0003-4661-8693 AD - University of California San Francisco, San Francisco, California, United States of America. FAU - Gopalakrishnan, Lakshmi AU - Gopalakrishnan L AD - University of California San Francisco, San Francisco, California, United States of America. FAU - Gelaye, Bizu AU - Gelaye B AD - Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America. FAU - Yousafzai, Aisha AU - Yousafzai A AUID- ORCID: 0000-0002-1592-8923 AD - Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America. FAU - Papatheodorou, Stefania AU - Papatheodorou S AD - Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America. AD - Rutgers School of Public Health, Piscataway, New Jersey, United States of America. LA - eng PT - Journal Article DEP - 20241028 PL - United States TA - PLOS Glob Public Health JT - PLOS global public health JID - 9918283779606676 PMC - PMC11516009 COIS- The authors have declared that no competing interests exist. EDAT- 2024/10/28 18:23 MHDA- 2024/10/28 18:24 PMCR- 2024/10/28 CRDT- 2024/10/28 13:44 PHST- 2024/01/19 00:00 [received] PHST- 2024/09/20 00:00 [accepted] PHST- 2024/10/28 18:24 [medline] PHST- 2024/10/28 18:23 [pubmed] PHST- 2024/10/28 13:44 [entrez] PHST- 2024/10/28 00:00 [pmc-release] AID - PGPH-D-23-02443 [pii] AID - 10.1371/journal.pgph.0003586 [doi] PST - epublish SO - PLOS Glob Public Health. 2024 Oct 28;4(10):e0003586. doi: 10.1371/journal.pgph.0003586. eCollection 2024. PMID- 39465988 OWN - NLM STAT- MEDLINE DCOM- 20250411 LR - 20260423 IS - 1461-7277 (Electronic) IS - 1359-1053 (Print) IS - 1359-1053 (Linking) VI - 30 IP - 5 DP - 2025 Apr TI - Psychological distress in Aotearoa New Zealand adults with type 1 diabetes. PG - 898-908 LID - 10.1177/13591053241289189 [doi] AB - The psychological burden of type 1 diabetes (T1D) can negatively impact health outcomes. This study evaluates the prevalence of low mood (WHO-5), disordered eating (DEPS-R), diabetes distress (PAID) and fear of hypoglycaemia (HFS-II), in a sample of 250 New Zealand adults (8.4% Maori/91.6% non-Maori; 43.6% female/56.4% male) with T1D using validated tools. Maori and female patients indicated low mood, with lower median WHO-5 scores than non-Maori (p = 0.027) and males (p = 0.002). Maori were more likely to score in the clinical range on the WHO-5, DEPS-R, PAID and HFS-II (all p < 0.05). HbA1c was correlated with emotional well-being (r(s) = -0.189), diabetes distress (r(s) = 0.223) and disordered eating (r(s) = 0.389; all p < 0.001) whilst DEPS-R correlated with age (r(s) = -0.232) and BMI (r(s) = 0.343; both p /=3.0, were of normal weight or overweight, physically inactive, and food secure, did not drink coffee or smoke, as well as in those whose neighbourhood contained grocery stores and/or public transportation (P < 0.05). In conclusion, during the pandemic, perceived mental well-being was moderate in a Jordanian sample of university students. Perceived psychological well-being was also positively associated with food security and academic performance. These findings suggest that improving food security and academic achievement may contribute to enhanced psychological well-being among university students. Therefore, higher education institutions with the help of the government are encouraged to facilitate the provision of mental health care services to students, mainly post the coronavirus, which according to our knowledge is limited. CI - (c) The Author(s) 2024. FAU - Mousa, Tamara Y AU - Mousa TY AUID- ORCID: 0000-0002-4046-3494 AD - Department of Nutrition and Food Technology, School of Agriculture, The University of Jordan, Amman, Jordan. FAU - Dardas, Latefa A AU - Dardas LA AD - Department of Community Health Nursing, School of Nursing, The University of Jordan, Amman, Jordan. LA - eng PT - Journal Article DEP - 20241010 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 SB - IM MH - Humans MH - *COVID-19/psychology/epidemiology MH - Jordan MH - *Students/psychology MH - Male MH - Female MH - Universities MH - Cross-Sectional Studies MH - *Food Insecurity MH - Young Adult MH - Risk Factors MH - *Mental Health MH - *SARS-CoV-2 MH - Adult MH - Surveys and Questionnaires MH - Academic Performance MH - Adolescent MH - Pandemics MH - Psychological Well-Being PMC - PMC11503852 OTO - NOTNLM OT - Arabic psychological general well-being index-short version (PGWB-S) OT - COVID-19 OT - Food insecurity OT - Jordan COIS- There was no conflict of interest. EDAT- 2024/10/28 06:22 MHDA- 2024/10/28 06:23 PMCR- 2024/01/01 CRDT- 2024/10/28 05:18 PHST- 2024/03/20 00:00 [received] PHST- 2024/08/03 00:00 [revised] PHST- 2024/08/30 00:00 [accepted] PHST- 2024/10/28 06:23 [medline] PHST- 2024/10/28 06:22 [pubmed] PHST- 2024/10/28 05:18 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - S2048679024000673 [pii] AID - 10.1017/jns.2024.67 [doi] PST - epublish SO - J Nutr Sci. 2024 Oct 10;13:e61. doi: 10.1017/jns.2024.67. eCollection 2024. PMID- 39464404 OWN - NLM STAT- MEDLINE DCOM- 20241028 LR - 20260923 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 13 DP - 2024 TI - Inequalities in diet quality by socio-demographic characteristics, smoking, and weight status in a large UK-based cohort using a new UK diet quality questionnaire-UKDQQ. PG - e59 LID - 10.1017/jns.2024.60 [doi] LID - e59 AB - The aim of this study was to explore the associations between diet quality, socio-demographic measures, smoking, and weight status in a large, cross-sectional cohort of adults living in Yorkshire and Humber, UK. Data from 43, 023 participants aged over 16 years in the Yorkshire Health Survey, 2(nd) wave (2013-2015) were collected on diet quality, socio-demographic measures, smoking, and weight status. Diet quality was assessed using a brief, validated tool. Associations between these variables were assessed using multiple regression methods. Split-sample cross-validation was utilised to establish model portability. Observed patterns in the sample showed that the greatest substantive differences in diet quality were between females and males (3.94 points; P < 0.001) and non-smokers vs smokers (4.24 points; P < 0.001), with higher diet quality scores observed in females and non-smokers. Deprivation, employment status, age, and weight status categories were also associated with diet quality. Greater diet quality scores were observed in those with lower levels of deprivation, those engaged in sedentary occupations, older people, and those in a healthy weight category. Cross-validation procedures revealed that the model exhibited good transferability properties. Inequalities in patterns of diet quality in the cohort were consistent with those indicated by the findings of other observational studies. The findings indicate population subgroups that are at higher risk of dietary-related ill health due to poor quality diet and provide evidence for the design of targeted national policy and interventions to prevent dietary-related ill health in these groups. The findings support further research exploring inequalities in diet quality in the population. CI - (c) The Author(s) 2024. FAU - Roberts, Kath AU - Roberts K AD - Department of Health Sciences and the Hull York Medical School, University of York, York, UK. AD - Sheffield Centre for Health and Related Research, School of Medicine and Population Health, University of Sheffield, Sheffield, UK. FAU - Stephenson, John AU - Stephenson J AD - School of Human & Health Sciences, University of Huddersfield, Huddersfield, UK. FAU - Holdsworth, Michelle AU - Holdsworth M AUID- ORCID: 0000-0001-6028-885X AD - UMR MoISA (Montpellier Interdisciplinary centre on Sustainable Agri-food systems), (Univ Montpellier, CIRAD, CIHEAM-IAMM, INRAE, Institut Agro, IRD), Montpellier, France. FAU - Relton, Clare AU - Relton C AD - Wolfson Institute for Population Health, Queen Mary University, London, UK. FAU - Williams, Elizabeth A AU - Williams EA AUID- ORCID: 0000-0002-1431-7549 AD - Sheffield Centre for Health and Related Research, School of Medicine and Population Health, University of Sheffield, Sheffield, UK. FAU - Cade, Janet Elizabeth AU - Cade JE AD - School of Food Science and Nutrition, University of Leeds, Leeds, UK. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241010 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 SB - IM MH - Humans MH - Male MH - Female MH - United Kingdom MH - Adult MH - Middle Aged MH - *Diet MH - *Smoking/epidemiology MH - Cross-Sectional Studies MH - *Socioeconomic Factors MH - Surveys and Questionnaires MH - Cohort Studies MH - *Body Weight MH - Aged MH - Adolescent MH - Young Adult MH - Sociodemographic Factors PMC - PMC11503710 OTO - NOTNLM OT - Diet quality OT - Diet quality questionnaire OT - Dietary assessment OT - Dietary ill-health OT - Dietary patterns OT - Disparities OT - Inequalities OT - Smoking OT - Socio-economic OT - Weight COIS- The authors declare no conflicts of interest. EDAT- 2024/10/28 06:22 MHDA- 2024/10/28 06:23 PMCR- 2024/01/01 CRDT- 2024/10/28 05:18 PHST- 2024/04/02 00:00 [received] PHST- 2024/07/02 00:00 [revised] PHST- 2024/08/27 00:00 [accepted] PHST- 2024/10/28 06:23 [medline] PHST- 2024/10/28 06:22 [pubmed] PHST- 2024/10/28 05:18 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - S2048679024000600 [pii] AID - 10.1017/jns.2024.60 [doi] PST - epublish SO - J Nutr Sci. 2024 Oct 10;13:e59. doi: 10.1017/jns.2024.60. eCollection 2024. PMID- 39463036 OWN - NLM STAT- MEDLINE DCOM- 20241125 LR - 20241125 IS - 1465-3478 (Electronic) IS - 0963-7486 (Linking) VI - 75 IP - 8 DP - 2024 Dec TI - Modelling the cost differential between current and healthy diets according to household education level in Belgium. PG - 882-897 LID - 10.1080/09637486.2024.2415126 [doi] AB - This study aims to estimate the cost differential between current and healthy diets, overall and by household education level. Data from the 2014-2015 Belgian National Food Consumption Survey and food prices from the 2014 GfK ConsumerScan panel were linked. The DIETCOST programme was used to model healthy, isocaloric healthy and current diets. For the reference household, the average daily diet cost was 20.1euro (95%CI: 19.9-20.4) for current diets, 20.9euro (95%CI: 20.6-21.2) for healthy isocaloric diets (+3.9% vs. the current diets) and 22.5euro (95%CI: 22.3-22.8) for healthy diets (+12.0%). In low-educated households, the cost of current and of healthy isocaloric diets was similar (19.2euro (95%CI: 19.0-19.5) vs. 19.3euro (95%CI: 19.0-19.6)), whereas in high-educated households, the cost of healthy isocaloric diets (22.0euro; 95%CI: 21.8-22.3) was higher than the cost of current diets (21.2euro; 95%CI: 20.9-21.4)). Though needing validation, this finding is valuable for interventions aimed at improving dietary habits in disadvantaged populations. FAU - Pedroni, Camille AU - Pedroni C AD - School of Public Health, Research Centre in "Epidemiology, Biostatistics and Clinical Research", Universite libre de Bruxelles (ULB), Brussels, Belgium. FAU - Castetbon, Katia AU - Castetbon K AD - School of Public Health, Research Centre in "Epidemiology, Biostatistics and Clinical Research", Universite libre de Bruxelles (ULB), Brussels, Belgium. FAU - Desbouys, Lucille AU - Desbouys L AD - School of Public Health, Research Centre in "Epidemiology, Biostatistics and Clinical Research", Universite libre de Bruxelles (ULB), Brussels, Belgium. FAU - Vandevijvere, Stefanie AU - Vandevijvere S AD - Department of Epidemiology and Public Health, Scientific Institute of Public Health (Sciensano), Unit "Lifestyle and Chronic Diseases", Brussels, Belgium. LA - eng PT - Journal Article DEP - 20241027 PL - England TA - Int J Food Sci Nutr JT - International journal of food sciences and nutrition JID - 9432922 SB - IM MH - Humans MH - Belgium MH - *Diet, Healthy/economics MH - *Family Characteristics MH - *Educational Status MH - Diet/economics MH - Adult MH - Male MH - Female MH - Middle Aged MH - Diet Surveys MH - Costs and Cost Analysis MH - Adolescent MH - Young Adult OTO - NOTNLM OT - Diet cost OT - diet modelling OT - education level OT - environmental impact OT - healthy diet EDAT- 2024/10/28 06:23 MHDA- 2024/11/25 11:34 CRDT- 2024/10/28 02:43 PHST- 2024/11/25 11:34 [medline] PHST- 2024/10/28 06:23 [pubmed] PHST- 2024/10/28 02:43 [entrez] AID - 10.1080/09637486.2024.2415126 [doi] PST - ppublish SO - Int J Food Sci Nutr. 2024 Dec;75(8):882-897. doi: 10.1080/09637486.2024.2415126. Epub 2024 Oct 27. PMID- 39462797 OWN - NLM STAT- MEDLINE DCOM- 20241202 LR - 20250312 IS - 1469-0705 (Electronic) IS - 0960-7692 (Print) IS - 0960-7692 (Linking) VI - 64 IP - 6 DP - 2024 Dec TI - Validation of Fetal Medicine Foundation charts for fetal growth in twins: nationwide Danish cohort study. PG - 730-738 LID - 10.1002/uog.29125 [doi] AB - OBJECTIVE: To assess the validity of the Fetal Medicine Foundation (FMF) chorionicity-specific models for fetal growth in twin pregnancy. METHODS: This was an external validation study of the FMF models using a nationwide Danish cohort of twin pregnancies. The cohort included all dichorionic (DC) and monochorionic diamniotic (MCDA) twin pregnancies with an estimated delivery date between 2008 and 2018, which satisfied the following inclusion criteria: two live fetuses at the first-trimester ultrasound scan (11-14 weeks' gestation); biometric measurements available for the calculation of estimated fetal weight (EFW) using the Hadlock-3 formula; and delivery of two liveborn infants. Validation involved assessing the distributional properties of the models and estimating the mean EFW Z-score deviations. Additionally, the models were applied to pregnancies that delivered preterm and attended non-scheduled visits (complicated pregnancies). RESULTS: Overall, 8542 DC and 1675 MCDA twin pregnancies met the inclusion criteria. In DC twins, 17 084 fetuses were evaluated at a total of 95 346 ultrasound scans, of which 44.5% were performed at scheduled visits in pregnancies carried to 37 + 0 weeks or later. The median number of growth scans per DC twin fetus from 20 + 0 weeks onwards was four. The model showed good agreement with the validation cohort for scheduled visits in DC twins delivered at 37 + 0 weeks or later (mean +/- SD EFW Z-score, -0.14 +/- 1.05). In MCDA twins, 3350 fetuses underwent 31 632 eligible ultrasound scans, of which 59.5% were performed at scheduled visits in pregnancies carried to 36 + 0 weeks or later. The median number of growth scans per MCDA twin fetus from 16 + 0 weeks onwards was 10. The model showed favorable agreement with the validation cohort for scheduled visits in MCDA twins delivered at 36 + 0 weeks or later (mean +/- SD EFW Z-score, -0.09 +/- 1.01). Non-scheduled visits and preterm delivery before 37 + 0 weeks for DC twins and before 36 + 0 weeks for MCDA twins corresponded with smaller weight estimates, which was consistent with the study's definition of complicated pregnancy. CONCLUSIONS: The FMF models provide a good fit for EFW measurements in our Danish national cohort of uncomplicated twin pregnancies assessed at routine scans. Therefore, the FMF models establish robust criteria for subsequent investigations and potential clinical applications. Future research should focus on exploring the consequences of clinical implementation, particularly regarding the identification of twins that are small-for-gestational age, as they are especially susceptible to adverse perinatal outcome. (c) 2024 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. CI - (c) 2024 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. FAU - Kristensen, S E AU - Kristensen SE AUID- ORCID: 0000-0003-4633-4738 AD - Center for Fetal Medicine, Pregnancy and Ultrasound, Department of Gynecology, Fertility and Obstetrics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. AD - Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. AD - Faculty of Health and Medical Sciences, Institute of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark. FAU - Wright, A AU - Wright A AD - Institute of Health Research, University of Exeter, Exeter, UK. FAU - Wright, D AU - Wright D AD - Institute of Health Research, University of Exeter, Exeter, UK. FAU - Gadsboll, K AU - Gadsboll K AD - Center for Fetal Medicine, Pregnancy and Ultrasound, Department of Gynecology, Fertility and Obstetrics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. AD - Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. FAU - Ekelund, C K AU - Ekelund CK AD - Center for Fetal Medicine, Pregnancy and Ultrasound, Department of Gynecology, Fertility and Obstetrics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. AD - Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. FAU - Sandager, P AU - Sandager P AD - Department of Obstetrics and Gynecology, Center for Fetal Medicine, Aarhus University Hospital, Aarhus, Denmark. AD - Center for Fetal Diagnostics, Aarhus University Hospital, Aarhus, Denmark. AD - Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. FAU - Jorgensen, F S AU - Jorgensen FS AD - Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. AD - Department of Obstetrics and Gynecology, Fetal Medicine Unit, Copenhagen University Hospital - Hvidovre and Amager, Hvidovre, Denmark. FAU - Hoseth, E AU - Hoseth E AD - Department of Obstetrics and Gynecology, Clinic of Ultrasound, Aalborg University Hospital, Aalborg, Denmark. FAU - Sperling, L AU - Sperling L AD - Department of Obstetrics and Gynecology, Center for Ultrasound and Pregnancy, Odense University Hospital, Odense, Denmark. FAU - Zingenberg, H J AU - Zingenberg HJ AD - Department of Obstetrics and Gynecology, Ultrasound in Pregnancy, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark. FAU - Sundberg, K AU - Sundberg K AD - Center for Fetal Medicine, Pregnancy and Ultrasound, Department of Gynecology, Fertility and Obstetrics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. FAU - McLennan, A AU - McLennan A AUID- ORCID: 0000-0002-8979-4534 AD - Sydney Ultrasound for Women, Chatswood, NSW, Australia. AD - Discipline of Obstetrics, Gynaecology and Neonatology, The University of Sydney, Sydney, NSW, Australia. FAU - Nicolaides, K H AU - Nicolaides KH AUID- ORCID: 0000-0003-1266-0711 AD - Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK. FAU - Petersen, O B AU - Petersen OB AUID- ORCID: 0000-0001-8517-4082 AD - Center for Fetal Medicine, Pregnancy and Ultrasound, Department of Gynecology, Fertility and Obstetrics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. AD - Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. LA - eng GR - NNFSA170030576/Novo Nordisk Fonden/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20241027 PL - England TA - Ultrasound Obstet Gynecol JT - Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology JID - 9108340 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Denmark MH - *Pregnancy, Twin/statistics & numerical data MH - *Fetal Development/physiology MH - *Ultrasonography, Prenatal/statistics & numerical data MH - *Fetal Weight MH - Cohort Studies MH - Adult MH - Gestational Age MH - Growth Charts MH - Infant, Newborn MH - Pregnancy Trimester, First PMC - PMC11609905 OTO - NOTNLM OT - dichorionic OT - external validation OT - fetal growth model OT - growth monitoring OT - monochorionic diamniotic OT - national cohort OT - singleton reference distribution OT - small-for-gestational age OT - twin pregnancy OT - twin reference distribution EDAT- 2024/10/28 06:23 MHDA- 2024/12/02 12:33 PMCR- 2024/12/02 CRDT- 2024/10/28 00:03 PHST- 2024/09/10 00:00 [revised] PHST- 2024/04/09 00:00 [received] PHST- 2024/09/26 00:00 [accepted] PHST- 2024/12/02 12:33 [medline] PHST- 2024/10/28 06:23 [pubmed] PHST- 2024/10/28 00:03 [entrez] PHST- 2024/12/02 00:00 [pmc-release] AID - UOG29125 [pii] AID - 10.1002/uog.29125 [doi] PST - ppublish SO - Ultrasound Obstet Gynecol. 2024 Dec;64(6):730-738. doi: 10.1002/uog.29125. Epub 2024 Oct 27. PMID- 39461723 OWN - NLM STAT- MEDLINE DCOM- 20250106 LR - 20260714 IS - 1938-3207 (Electronic) IS - 0002-9165 (Print) IS - 0002-9165 (Linking) VI - 121 IP - 1 DP - 2025 Jan TI - Maternal diet in pregnancy and the risk of inflammatory bowel disease in the offspring: a prospective cohort study. PG - 32-39 LID - S0002-9165(24)00858-X [pii] LID - 10.1016/j.ajcnut.2024.10.017 [doi] AB - BACKGROUND: Diet has been hypothesized as a risk factor for the development of inflammatory bowel disease (IBD). OBJECTIVE: The objective of this study was to explore associations between maternal diet diversity and quality in pregnancy and the offspring's risk of IBD. METHODS: We used data from a nationwide cohort study on 85,129 Norwegian children followed from birth (1999-2009) with information on maternal diet in pregnancy from validated food frequency questionnaires. Hazard ratios (HRs) for IBD, Crohn disease (CD), and ulcerative colitis (UC) by maternal diet diversity, quality, and intake amounts of individual food groups were adjusted for maternal BMI, parental IBD, and sociodemographic factors. Sensitivity analyses were adjusted for the child's early-life diet quality and antibiotic treatment. Dietary exposures were classified into tertiles, comparing low (reference) with medium, and high levels. RESULTS: During a mean follow-up time of 16.1 y (1,367,837 person-years of follow-up), 268 children developed IBD (CD, n = 119; UC, n = 76; IBD-unclassified, n = 73). High compared with low diet diversity in pregnancy was associated with a lower risk of UC in the offspring [adjusted HR (aHR) 0.46, 95% confidence interval: 0.25, 0.87], with consistent findings after further adjustment for the child's early-life diet quality and antibiotic treatment. High compared with low diet diversity in pregnancy yielded aHRs of 0.81 for CD (0.51-1.28) and 0.75 for any IBD (0.55-1.02) in the offspring. A high compared with low diet quality in pregnancy or intakes of specific food groups were not associated with the offspring's risk of IBD or its subtypes. CONCLUSIONS: Our findings suggest that a higher maternal diet diversity in pregnancy may be associated with a lower risk of UC in the offspring. CI - Copyright (c) 2024 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Guo, Annie AU - Guo A AD - Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address: annie.guo@gu.se. FAU - Brantsaeter, Anne Lise AU - Brantsaeter AL AD - Department of Food Safety and Centre for Sustainable Diets, Norwegian Institute of Public Health, Oslo, Norway. FAU - Borge, Tiril Cecilie AU - Borge TC AD - Cluster for Reviews and Health Technology Assessments, Norwegian Institute of Public Health, Oslo, Norway. FAU - M Hard Af Segerstad, Elin AU - M Hard Af Segerstad E AD - Pediatric Research Institute, Oslo University Hospital and Faculty of Medicine, University of Oslo, Oslo, Norway. FAU - Imberg, Henrik AU - Imberg H AD - Statistiska Konsultgruppen Sweden, Gothenburg, Sweden; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Marild, Karl AU - Marild K AD - Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Pediatrics, Queen Silvia Children's Hospital, Gothenburg, Sweden. FAU - Stordal, Ketil AU - Stordal K AD - Pediatric Research Institute, Oslo University Hospital and Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Child and Adolescent Health, Oslo University Hospital, Oslo, Norway. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241024 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Diet MH - Prospective Studies MH - *Inflammatory Bowel Diseases/epidemiology MH - Risk Factors MH - Adult MH - Male MH - *Maternal Nutritional Physiological Phenomena MH - Norway/epidemiology MH - Prenatal Exposure Delayed Effects MH - Child MH - Cohort Studies MH - Adolescent PMC - PMC11747187 OTO - NOTNLM OT - Crohn disease OT - MoBa OT - pregnancy OT - ulcerative colitis COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2024/10/27 17:11 MHDA- 2025/01/07 00:21 PMCR- 2024/10/24 CRDT- 2024/10/26 19:28 PHST- 2024/06/24 00:00 [received] PHST- 2024/10/15 00:00 [revised] PHST- 2024/10/18 00:00 [accepted] PHST- 2025/01/07 00:21 [medline] PHST- 2024/10/27 17:11 [pubmed] PHST- 2024/10/26 19:28 [entrez] PHST- 2024/10/24 00:00 [pmc-release] AID - S0002-9165(24)00858-X [pii] AID - 10.1016/j.ajcnut.2024.10.017 [doi] PST - ppublish SO - Am J Clin Nutr. 2025 Jan;121(1):32-39. doi: 10.1016/j.ajcnut.2024.10.017. Epub 2024 Oct 24. PMID- 39460185 OWN - NLM STAT- MEDLINE DCOM- 20241026 LR - 20241028 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 24 IP - 20 DP - 2024 Oct 18 TI - Evaluation of the ActiMotus Software to Accurately Classify Postures and Movements in Children Aged 3-14. LID - 10.3390/s24206705 [doi] LID - 6705 AB - BACKGROUND: ActiMotus, a thigh-accelerometer-based software used for the classification of postures and movements (PaMs), has shown high accuracy among adults and school-aged children; however, its accuracy among younger children and potential differences between sexes are unknown. This study aimed to evaluate the accuracy of ActiMotus to measure PaMs among children between 3 and 14 years and to assess if this was influenced by the sex or age of children. METHOD: Forty-eight children attended a structured ~1-hour data collection session at a laboratory. Thigh acceleration was measured using a SENS accelerometer, which was classified into nine PaMs using the ActiMotus software. Human-coded video recordings of the session provided the ground truth. RESULTS: Based on both F1 scores and balanced accuracy, the highest levels of accuracy were found for lying, sitting, and standing (63.2-88.2%). For walking and running, accuracy measures ranged from 48.0 to 85.8%. The lowest accuracy was observed for classifying stair climbing. We found a higher accuracy for stair climbing among girls compared to boys and for older compared to younger age groups for walking, running, and stair climbing. CONCLUSIONS: ActiMotus could accurately detect lying, sitting, and standing among children. The software could be improved for classifying walking, running, and stair climbing, particularly among younger children. FAU - Lund Rasmussen, Charlotte AU - Lund Rasmussen C AUID- ORCID: 0000-0003-2193-5019 AD - School of Allied Health, Curtin University, Perth, WA 6102, Australia. AD - ARC Centre of Excellence for the Digital Child, Brisbane, ACT 2609, Australia. FAU - Hendry, Danica AU - Hendry D AUID- ORCID: 0000-0001-8701-2212 AD - School of Allied Health, Curtin University, Perth, WA 6102, Australia. AD - ARC Centre of Excellence for the Digital Child, Brisbane, ACT 2609, Australia. FAU - Thomas, George AU - Thomas G AUID- ORCID: 0000-0001-6908-7974 AD - School of Allied Health, Curtin University, Perth, WA 6102, Australia. AD - ARC Centre of Excellence for the Digital Child, Brisbane, ACT 2609, Australia. AD - Health and Wellbeing Centre for Research Innovation, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD 4006, Australia. FAU - Beynon, Amber AU - Beynon A AUID- ORCID: 0000-0002-1302-4429 AD - School of Allied Health, Curtin University, Perth, WA 6102, Australia. AD - ARC Centre of Excellence for the Digital Child, Brisbane, ACT 2609, Australia. FAU - Stearne, Sarah Michelle AU - Stearne SM AUID- ORCID: 0000-0001-5278-2532 AD - School of Allied Health, Curtin University, Perth, WA 6102, Australia. AD - ARC Centre of Excellence for the Digital Child, Brisbane, ACT 2609, Australia. FAU - Zabatiero, Juliana AU - Zabatiero J AUID- ORCID: 0000-0002-6815-7544 AD - School of Allied Health, Curtin University, Perth, WA 6102, Australia. AD - ARC Centre of Excellence for the Digital Child, Brisbane, ACT 2609, Australia. FAU - Davey, Paul AU - Davey P AUID- ORCID: 0000-0002-2119-8066 AD - School of Nursing, Curtin University, Perth, WA 6102, Australia. FAU - Roslyng Larsen, Jon AU - Roslyng Larsen J AUID- ORCID: 0000-0003-0373-9305 AD - The National Research Centre for the Working Environment, 2100 Copenhagen, Denmark. FAU - Rohl, Andrew Lloyd AU - Rohl AL AUID- ORCID: 0000-0003-0038-2785 AD - ARC Centre of Excellence for the Digital Child, Brisbane, ACT 2609, Australia. AD - School of Electrical Engineering, Computing and Mathematical Sciences, Curtin University, Perth, WA 6102, Australia. AD - Curtin Institute for Data Science, Curtin University, Perth, WA 6102, Australia. FAU - Straker, Leon AU - Straker L AUID- ORCID: 0000-0002-7786-4128 AD - School of Allied Health, Curtin University, Perth, WA 6102, Australia. AD - ARC Centre of Excellence for the Digital Child, Brisbane, ACT 2609, Australia. FAU - Campbell, Amity AU - Campbell A AUID- ORCID: 0000-0002-6461-6280 AD - School of Allied Health, Curtin University, Perth, WA 6102, Australia. AD - ARC Centre of Excellence for the Digital Child, Brisbane, ACT 2609, Australia. LA - eng GR - CE200100022/the Australian Research Council/ GR - NA/the Curtin School of Allied Health 2022 Teaching and Research Grant/ PT - Journal Article DEP - 20241018 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - Adolescent MH - *Posture/physiology MH - *Software MH - *Movement/physiology MH - Child, Preschool MH - *Accelerometry/methods MH - Walking/physiology MH - Running/physiology PMC - PMC11510827 OTO - NOTNLM OT - accelerometry OT - physical activity OT - sedentary behaviour OT - validation COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2024/10/26 19:21 MHDA- 2024/10/26 19:22 PMCR- 2024/10/18 CRDT- 2024/10/26 01:24 PHST- 2024/09/16 00:00 [received] PHST- 2024/10/10 00:00 [revised] PHST- 2024/10/16 00:00 [accepted] PHST- 2024/10/26 19:22 [medline] PHST- 2024/10/26 19:21 [pubmed] PHST- 2024/10/26 01:24 [entrez] PHST- 2024/10/18 00:00 [pmc-release] AID - s24206705 [pii] AID - sensors-24-06705 [pii] AID - 10.3390/s24206705 [doi] PST - epublish SO - Sensors (Basel). 2024 Oct 18;24(20):6705. doi: 10.3390/s24206705. PMID- 39458488 OWN - NLM STAT- MEDLINE DCOM- 20241026 LR - 20241028 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 20 DP - 2024 Oct 15 TI - Validation of the Modified Yale Food Addiction Scale 2.0 (mYFAS 2.0) in Spanish University Students. LID - 10.3390/nu16203492 [doi] LID - 3492 AB - OBJECTIVE: The aim of this study was to explore the factorial structure, psychometric properties and association with anthropometric and clinical variables of the Modified Yale Addiction Scale 2.0 (mYFAS 2.0) in a Spanish university population. METHODS: A cross-sectional study of n = 270 university students in Spain was conducted. VARIABLES MEASURED: mYFAS 2.0, Emotional Eater Questionnaire (EEQ), Alcohol Use Disorder Identification Test (AUDIT), Pittsburg Sleep Quality index (PSQI) and Perceived Stress Scale (PSS). In mYFAS 2.0 were performed an Exploratory Factor Analysis (EFA), an Unweight Least Square (ULS), a model fit using comparative fit index (CFI) and nomological validity. RESULTS: EFA revealed that a two-factor structure is the most appropriate in a non-clinical population of Spanish university students. The factors accounted for 18.54% and 16.33% of the variance, and the correlation between them was moderate-0.487 (p < 0.001). This different structure from that reported in the original scale could be derived from the cultural characteristics and intrinsic eating habits of the study population. The correlation matrix reported an inverse association of mYFAS 2.0 with Body Mass Index (BMI). In addition, participants with a BMI below 25 showed a higher mYFAS 2.0 and EEQ score. CONCLUSIONS: These results suggest some changes in the psychometric assessment structure of the mYFAS 2.0 in a non-clinical population of university students, as well as the usefulness of this questionnaire to identify individuals with an adequate BMI but with compensatory behaviours that predispose to different eating disorders. FAU - Lopez-Moreno, Miguel AU - Lopez-Moreno M AUID- ORCID: 0000-0003-0553-6210 AD - Instituto de Investigacion en Ciencias de Alimentacion, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, 28049 Madrid, Spain. AD - Grupo de Investigacion en Biotecnologia Alimentaria, Universidad Francisco de Vitoria, 28223 Madrid, Spain. AD - Faculty of Health Sciences, Universidad Francisco de Vitoria (UFV), Pozuelo de Alarcon, 28223 Madrid, Spain. FAU - Marchena-Giraldez, Carlos AU - Marchena-Giraldez C AUID- ORCID: 0000-0003-0178-4276 AD - Faculty of Education and Psychology, Universidad Francisco de Vitoria (UFV), Pozuelo de Alarcon, 28223 Madrid, Spain. FAU - Garces-Rimon, Marta AU - Garces-Rimon M AUID- ORCID: 0000-0002-3888-4150 AD - Instituto de Investigacion en Ciencias de Alimentacion, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, 28049 Madrid, Spain. AD - Grupo de Investigacion en Biotecnologia Alimentaria, Universidad Francisco de Vitoria, 28223 Madrid, Spain. FAU - Miguel-Castro, Marta AU - Miguel-Castro M AUID- ORCID: 0000-0002-5525-1056 AD - Instituto de Investigacion en Ciencias de Alimentacion, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, 28049 Madrid, Spain. AD - Grupo de Investigacion en Biotecnologia Alimentaria, Universidad Francisco de Vitoria, 28223 Madrid, Spain. FAU - Iglesias-Lopez, Maria Teresa AU - Iglesias-Lopez MT AUID- ORCID: 0000-0003-4511-5592 AD - Grupo de Investigacion en Biotecnologia Alimentaria, Universidad Francisco de Vitoria, 28223 Madrid, Spain. AD - Faculty of Health Sciences, Universidad Francisco de Vitoria (UFV), Pozuelo de Alarcon, 28223 Madrid, Spain. LA - eng GR - UFV 2022-26/Universidad Francisco de Vitoria/ PT - Journal Article PT - Validation Study DEP - 20241015 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - *Students/psychology/statistics & numerical data MH - Male MH - Spain/epidemiology MH - *Food Addiction/psychology/diagnosis MH - Universities MH - Cross-Sectional Studies MH - Young Adult MH - *Psychometrics MH - Surveys and Questionnaires/standards MH - Adult MH - Reproducibility of Results MH - Factor Analysis, Statistical MH - Adolescent MH - Body Mass Index MH - Feeding Behavior/psychology PMC - PMC11510001 OTO - NOTNLM OT - food addiction OT - mYFAS 2.0 OT - psychometric factor OT - university students COIS- The authors declare no conflict of interest. EDAT- 2024/10/26 19:22 MHDA- 2024/10/26 19:23 PMCR- 2024/10/15 CRDT- 2024/10/26 01:15 PHST- 2024/09/26 00:00 [received] PHST- 2024/10/12 00:00 [revised] PHST- 2024/10/14 00:00 [accepted] PHST- 2024/10/26 19:23 [medline] PHST- 2024/10/26 19:22 [pubmed] PHST- 2024/10/26 01:15 [entrez] PHST- 2024/10/15 00:00 [pmc-release] AID - nu16203492 [pii] AID - nutrients-16-03492 [pii] AID - 10.3390/nu16203492 [doi] PST - epublish SO - Nutrients. 2024 Oct 15;16(20):3492. doi: 10.3390/nu16203492. PMID- 39457267 OWN - NLM STAT- MEDLINE DCOM- 20241026 LR - 20260727 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 21 IP - 10 DP - 2024 Sep 28 TI - Psychometric Properties of the PLAYself in a Cohort of Secondary School Student-Athletes. LID - 10.3390/ijerph21101294 [doi] LID - 1294 AB - BACKGROUND: Physical literacy is the motivation, confidence, physical competence, knowledge, and understanding, enabling individuals to value and take responsibility for engagement in physical activities for life. While tools exist to measure physical literacy in most populations, the psychometric properties of the Physical Literacy Assessment for Youth (PLAY) tool in an older adolescent age group are currently unknown. The purpose of this work was to determine the psychometric properties of the PLAY tool, specifically the PLAYself, in an older adolescent age group (~14-18 years). METHODS: One hundred and fifty-one secondary school in-season student-athletes completed the PLAYself, with construct validity assessed using an Exploratory Factor Analysis (EFA). RESULTS: Results from the EFA yielded a 7-factor model across the three subsections (environment, physical literacy self-description, relative rankings of literacies) of the PLAYself, all with acceptable levels of internal consistency. CONCLUSIONS: The PLAYself produced acceptable estimates for construct validity and reliability, making it a useful tool for measuring physical literacy in secondary school student-athletes. FAU - Lininger, Monica R AU - Lininger MR AD - Department of Physical Therapy and Athletic Training, Northern Arizona University, Flagstaff, AZ 86011, USA. FAU - Root, Hayley J AU - Root HJ AD - Department of Physical Therapy and Athletic Training, Northern Arizona University, Flagstaff, AZ 86011, USA. LA - eng GR - Professorship, not grant/Northern Arizona University/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240928 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - Adolescent MH - *Psychometrics MH - Male MH - Female MH - *Students/psychology MH - *Athletes/psychology MH - Schools MH - Reproducibility of Results MH - Surveys and Questionnaires MH - Cohort Studies PMC - PMC11507620 OTO - NOTNLM OT - physical activity OT - physical literacy OT - sports OT - youth COIS- The authors declare no conflicts of interest. EDAT- 2024/10/26 19:22 MHDA- 2024/10/26 19:23 PMCR- 2024/09/28 CRDT- 2024/10/26 01:08 PHST- 2024/08/06 00:00 [received] PHST- 2024/09/24 00:00 [revised] PHST- 2024/09/24 00:00 [accepted] PHST- 2024/10/26 19:23 [medline] PHST- 2024/10/26 19:22 [pubmed] PHST- 2024/10/26 01:08 [entrez] PHST- 2024/09/28 00:00 [pmc-release] AID - ijerph21101294 [pii] AID - ijerph-21-01294 [pii] AID - 10.3390/ijerph21101294 [doi] PST - epublish SO - Int J Environ Res Public Health. 2024 Sep 28;21(10):1294. doi: 10.3390/ijerph21101294. PMID- 39457208 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241029 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 11 IP - 10 DP - 2024 Oct 16 TI - The MapMe Body Scales: Validity and Reliability of a Biometrically Accurate, Photorealistic Set of Child Body Size Scales. LID - 10.3390/children11101243 [doi] LID - 1243 AB - BACKGROUND/OBJECTIVES: It is vital to identify children whose weight status means that they may benefit from medical or behavioural support, but adult visual judgements of child weight status are inaccurate, and children are seldom routinely weighed and measured. Consequently, there is a need for validated visual tools for use in training, communication, and interventions relating to child weight. METHODS: This paper presents validation data for a set of innovative photo-realistic colour body size scales depicting boys and girls aged 4-5 and 10-11. Each age- and gender-specific scale consists of 7 figures based on three-dimensional (3D) scans of 388 children to accurately represent the change in body size caused by changing adiposity. To assess scale validity, 238 adult participants (105 men, 132 women, 1 non-binary individual) undertook two tasks: rating figure adiposity using a visual analogue scale and ranking figures in ascending order of adiposity (OSF Reference: gdp9j). RESULTS: Participants accurately estimated the relative adiposity of each figure, i.e., they were able to tell the difference between figures and correctly rank them by size. This demonstrates scale validity for use in body size tasks. One hundred and fifty-one participants also provided 3-day test-retest data, which demonstrates excellent short-term reliability. CONCLUSIONS: Overall, the MapMe child body size scales provide an anthropometrically accurate, valid, reliable, and usable tool for size-related tasks and communication with adults regarding child weight. FAU - Ridley, Bethany J AU - Ridley BJ AUID- ORCID: 0000-0002-2611-5338 AD - Department of Psychology, Northumbria University, Newcastle upon Tyne NE1 8ST, UK. FAU - Evans, Elizabeth H AU - Evans EH AUID- ORCID: 0000-0002-3432-3778 AD - Department of Psychology, Durham University, Durham DH1 3LE, UK. FAU - Cornelissen, Piers L AU - Cornelissen PL AUID- ORCID: 0000-0002-2695-9581 AD - Department of Psychology, Northumbria University, Newcastle upon Tyne NE1 8ST, UK. FAU - Kramer, Robin S S AU - Kramer RSS AUID- ORCID: 0000-0001-8339-8832 AD - School of Psychology, University of Lincoln, Lincoln LN6 7TS, UK. FAU - Tovee, Martin J AU - Tovee MJ AUID- ORCID: 0000-0001-9642-4462 AD - Department of Psychology, Northumbria University, Newcastle upon Tyne NE1 8ST, UK. LA - eng GR - NIHR127745/National Institute for Health and Care Research/ PT - Journal Article DEP - 20241016 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC11506425 OTO - NOTNLM OT - BMI categories OT - body size perception OT - childhood weight OT - overweight COIS- The authors declare that there are no conflicts of interest. EDAT- 2024/10/26 19:25 MHDA- 2024/10/26 19:26 PMCR- 2024/10/16 CRDT- 2024/10/26 01:07 PHST- 2024/07/30 00:00 [received] PHST- 2024/10/01 00:00 [revised] PHST- 2024/10/14 00:00 [accepted] PHST- 2024/10/26 19:26 [medline] PHST- 2024/10/26 19:25 [pubmed] PHST- 2024/10/26 01:07 [entrez] PHST- 2024/10/16 00:00 [pmc-release] AID - children11101243 [pii] AID - children-11-01243 [pii] AID - 10.3390/children11101243 [doi] PST - epublish SO - Children (Basel). 2024 Oct 16;11(10):1243. doi: 10.3390/children11101243. PMID- 39456355 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241029 IS - 2304-8158 (Print) IS - 2304-8158 (Electronic) IS - 2304-8158 (Linking) VI - 13 IP - 20 DP - 2024 Oct 17 TI - Visual Cues, Liking, and Emotional Responses: What Combination of Factors Result in the Willingness to Eat Vegetables Among Children with Food Neophobia? LID - 10.3390/foods13203294 [doi] LID - 3294 AB - Childhood nutrition is a cornerstone of long-term health, yet many children exhibit reluctance to consume healthy foods such as vegetables. This aversion can be influenced by various factors, including food neophobia and the sensory and visual appeal of the foods that are being presented. Hence, understanding how visual cues affect children's willingness to eat can provide insights into effective strategies to enhance their dietary habits. This research explores the influence of visual cues on the dietary behaviors of children aged 9 to 12, their willingness to consume and request healthy foods such as vegetables, within the context of challenges such as food neophobia. This study examines how intrinsic cues (e.g., vegetable characteristics) and extrinsic cues (e.g., the plate's color and shape) affect children's liking and emotional responses, impacting their willingness to eat and request purchases from parents. Conducted using a sample of 420 children, this cross-sectional study reveals that attributes such as a plate's color and shape significantly affect food-related behaviors and emotions. A validated and reliable self-administered questionnaire was employed. Independent t-tests and ANOVA were used to test the differences between gender and food neophobia, while Spearman correlations were used for correlation analysis. Visual cues served as the independent variables, liking and emotional responses as the mediating variables, and willingness behaviors as the dependent variable. Hierarchical regression analyses were conducted to explore the relationships among intrinsic cues, extrinsic cues, and the mediating effect of liking and emotional responses. Findings show that boys prefer blue and triangular plates, while girls prefer pink plates, generating more positive emotions. Children with food neophobia initially experience aversion, but this can be reduced by enhancing sensory appeal and emotional engagement. The findings underscore the importance of leveraging visual cues and fostering positive emotional experiences to encourage healthier eating habits and increase children's acceptance and purchase of nutritious foods. FAU - Tan, Xiaoqin AU - Tan X AUID- ORCID: 0009-0002-5725-3714 AD - Department of Integrated Design, Faculty of Design and Architecture, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia. FAU - Abdul Shukor, Shureen Faris AU - Abdul Shukor SF AUID- ORCID: 0000-0002-4811-2234 AD - Department of Landscape Architecture, Faculty of Design and Architecture, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia. FAU - Soh, Kim Geok AU - Soh KG AUID- ORCID: 0000-0002-5273-2700 AD - Department of Sports Studies, Faculty of Educational Studies, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia. LA - eng PT - Journal Article DEP - 20241017 PL - Switzerland TA - Foods JT - Foods (Basel, Switzerland) JID - 101670569 PMC - PMC11507587 OTO - NOTNLM OT - color OT - extrinsic cues OT - intrinsic cues OT - plate OT - shape COIS- The authors declare no conflicts of interest. EDAT- 2024/10/26 19:26 MHDA- 2024/10/26 19:27 PMCR- 2024/10/17 CRDT- 2024/10/26 01:02 PHST- 2024/09/26 00:00 [received] PHST- 2024/10/11 00:00 [revised] PHST- 2024/10/15 00:00 [accepted] PHST- 2024/10/26 19:27 [medline] PHST- 2024/10/26 19:26 [pubmed] PHST- 2024/10/26 01:02 [entrez] PHST- 2024/10/17 00:00 [pmc-release] AID - foods13203294 [pii] AID - foods-13-03294 [pii] AID - 10.3390/foods13203294 [doi] PST - epublish SO - Foods. 2024 Oct 17;13(20):3294. doi: 10.3390/foods13203294. PMID- 39455332 OWN - NLM STAT- MEDLINE DCOM- 20250425 LR - 20250516 IS - 1590-3729 (Electronic) IS - 0939-4753 (Linking) VI - 35 IP - 5 DP - 2025 May TI - Comparison between Friedewald's and Sampson's formulas in the estimation of high levels of measured LDL-cholesterol in youth with obesity. PG - 103753 LID - S0939-4753(24)00373-9 [pii] LID - 10.1016/j.numecd.2024.09.023 [doi] AB - BACKGROUND AND AIM: To assess the performance of Friedewald's and Sampson's formulas in relation to high or borderline-high levels of measured LDL-Cholesterol (LDL-C) in youths with overweight/obesity (OW/OB). METHODS AND RESULTS: A cross-sectional study was performed in 1694 youths (age 5-17 years) with OW/OB observed in Italian centers of Messina (group 1) and Naples (group 2). LDL-C levels were both measured and calculated using Friedewald's (LDL-C(F)) and Sampson's (LDL-C(S)) formulas. The two groups were similar for sex, age, BMI, BMI Z-score, and measured LDL-C. Levels of LDL-C(F) and LDL-C(S) were higher in group 1 than group 2. In the overall sample, 9.9 % youths had measured LDL-C >/=130 mg/dL and 27.8 % >/= 110 mg/dL, without differences between centers. The two formulas showed comparable high sensitivity and specificity in relation to levels of measured LDL-C >/=130 mg/dL or >/=110 mg/dL. However, LDL-C(F) showed a higher positive predictive value than LDL-C(S). CONCLUSIONS: Both formulas estimate with high accuracy measured LDL-C levels in youths with OW/OB. Therefore, calculated LDL-C can be a useful tool for universal screening when direct LDL-C measurement is not available. The Friedewald's formula is more feasible in clinical practice for simplicity of calculation. CI - Copyright (c) 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved. FAU - Di Bonito, Procolo AU - Di Bonito P AD - Department of Internal Medicine, "S. Maria delle Grazie" Hospital, Pozzuoli, Italy. FAU - Corica, Domenico AU - Corica D AD - Department of Human Pathology in Adulthood and Childhood, University of Messina, Messina, Italy. FAU - Wasniewska, Malgorzata Gabriela AU - Wasniewska MG AD - Department of Human Pathology in Adulthood and Childhood, University of Messina, Messina, Italy. FAU - Di Sessa, Anna AU - Di Sessa A AD - Department of Woman, Child and of General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Napoli, Italy. FAU - Miraglia Del Giudice, Emanuele AU - Miraglia Del Giudice E AD - Department of Woman, Child and of General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Napoli, Italy. FAU - Licenziati, Maria Rosaria AU - Licenziati MR AD - Obesity and Endocrine Disease Unit, Department of Neuroscience, Santobono-Pausilipon Children's Hospital, Napoli, Italy. FAU - Improda, Nicola AU - Improda N AD - Obesity and Endocrine Disease Unit, Department of Neuroscience, Santobono-Pausilipon Children's Hospital, Napoli, Italy. FAU - Valerio, Giuliana AU - Valerio G AD - Department of Medical, Movement and Wellbeing Sciences, University "Parthenope", Napoli, Italy. Electronic address: giuliana.valerio@uniparthenope.it. LA - eng PT - Comparative Study PT - Journal Article PT - Multicenter Study DEP - 20240926 PL - Netherlands TA - Nutr Metab Cardiovasc Dis JT - Nutrition, metabolism, and cardiovascular diseases : NMCD JID - 9111474 RN - 0 (Cholesterol, LDL) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Child MH - Adolescent MH - Female MH - Male MH - Cross-Sectional Studies MH - *Cholesterol, LDL/blood MH - *Pediatric Obesity/blood/diagnosis/epidemiology MH - Predictive Value of Tests MH - Italy/epidemiology MH - Biomarkers/blood MH - Child, Preschool MH - Age Factors MH - Reproducibility of Results MH - *Hypercholesterolemia/diagnosis/blood/epidemiology MH - Up-Regulation OTO - NOTNLM OT - Cardiovascular risk OT - Dyslipidemia OT - Pediatric obesity OT - Screening COIS- Declaration of competing interest The authors have no conflicts of interest to disclose. EDAT- 2024/10/26 19:26 MHDA- 2025/04/25 06:28 CRDT- 2024/10/25 21:59 PHST- 2024/06/15 00:00 [received] PHST- 2024/09/12 00:00 [revised] PHST- 2024/09/23 00:00 [accepted] PHST- 2025/04/25 06:28 [medline] PHST- 2024/10/26 19:26 [pubmed] PHST- 2024/10/25 21:59 [entrez] AID - S0939-4753(24)00373-9 [pii] AID - 10.1016/j.numecd.2024.09.023 [doi] PST - ppublish SO - Nutr Metab Cardiovasc Dis. 2025 May;35(5):103753. doi: 10.1016/j.numecd.2024.09.023. Epub 2024 Sep 26. PMID- 39455060 OWN - NLM STAT- MEDLINE DCOM- 20250424 LR - 20250516 IS - 1558-688X (Electronic) IS - 0031-5125 (Linking) VI - 132 IP - 2 DP - 2025 Apr TI - Psychometric Properties of the Hungarian Passion Scale-8 (PS-8-HU) in Physically Active and Inactive Adults. PG - 243-261 LID - 10.1177/00315125241296611 [doi] AB - The 8-item Passion Scale (PS-8) is a unidimensional instrument used in dual versus single passion research. The PS-8 was validated in Icelandic, Persian, and Turkish student samples. In this study, we translated the PS-8 and validated it with physically active and inactive adults from Hungary. We also evaluated measurement invariance (across gender, physical activity, exercise frequency, and age groups) of the Hungarian version of the Passion scale (PS-8-HU). Data were collected online between fall 2023 and winter 2024, including a test and retest phase. The sample comprised 729 Hungarian physically active and inactive adults (68% females, 32% males; ages 18-78 years), of whom 196 participated in the retest. We used confirmatory factor analysis (CFA), item analysis, correlations, t-test and ANOVA in checking the scale's validity and reliability, and we used a multigroup CFA to test the measurement invariance. The results supperted a univariate structure of the PS-8-HU. The instrument was invariant for gender (at the strict level), exercise frequency (metric), physical activity (metric), and age (scalar). The internal reliability of the PS-8-HU was .93 and test-retest reliability was .77. The PS-8-HU also exhibited good concurrent and construct validities, high homogeneity, and adequate discriminant validity. FAU - Arok, Palma AU - Arok P AUID- ORCID: 0009-0005-9410-6846 AD - Institute of Physiotherapy and Sport Science, Faculty of Health Science, University of Pecs, Pecs, Hungary. RINGGOLD: 37656 FAU - Morvay-Sey, Kata AU - Morvay-Sey K AD - Department of Sport Science, Faculty of Health Sciences, University of Pecs, Pecs, Hungary. RINGGOLD: 37656 FAU - Vujic, Aleksandar AU - Vujic A AUID- ORCID: 0000-0002-5235-114X AD - Doctoral School of Psychology, Faculty of Education and Psychology, ELTE Eotvos Lorand University, Budapest, Hungary. RINGGOLD: 54616 AD - Institute of Psychology, Faculty of Education and Psychology, ELTE Eotvos Lorand University, Budapest, Hungary. RINGGOLD: 54616 FAU - Szabo, Attila AU - Szabo A AUID- ORCID: 0000-0003-2788-4304 AD - Institute of Psychology, Faculty of Education and Psychology, ELTE Eotvos Lorand University, Budapest, Hungary. RINGGOLD: 54616 AD - Institute of Health Promotion and Sport Sciences, Faculty of Education and Psychology, ELTE Eotvos Lorand University, Budapest, Hungary. RINGGOLD: 54616 LA - eng PT - Journal Article DEP - 20241025 PL - United States TA - Percept Mot Skills JT - Perceptual and motor skills JID - 0401131 SB - IM MH - Humans MH - Adult MH - Male MH - Female MH - *Psychometrics/instrumentation/standards MH - Middle Aged MH - Adolescent MH - Young Adult MH - Hungary MH - *Exercise/psychology MH - Aged MH - Reproducibility of Results MH - *Emotions/physiology MH - *Sedentary Behavior OTO - NOTNLM OT - exercise OT - gender OT - passion OT - passion psychometrics OT - physical activity COIS- Declaration of Conflicting InterestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Authors Palma Arok, Kata-Morvay Sey, Aleksandar Vujic, and Attila Szabo have no conflict of interest to declare. EDAT- 2024/10/26 19:22 MHDA- 2025/03/27 05:27 CRDT- 2024/10/25 20:03 PHST- 2025/03/27 05:27 [medline] PHST- 2024/10/26 19:22 [pubmed] PHST- 2024/10/25 20:03 [entrez] AID - 10.1177/00315125241296611 [doi] PST - ppublish SO - Percept Mot Skills. 2025 Apr;132(2):243-261. doi: 10.1177/00315125241296611. Epub 2024 Oct 25. PMID- 39451579 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241027 IS - 2075-4418 (Print) IS - 2075-4418 (Electronic) IS - 2075-4418 (Linking) VI - 14 IP - 20 DP - 2024 Oct 10 TI - The Validity of the Original and the Saudi-Modified Screening Tools for the Assessment of Malnutrition in Pediatrics: A Cross-Sectional Study. LID - 10.3390/diagnostics14202256 [doi] LID - 2256 AB - Background: Screening for malnutrition among hospitalized children is essential, and the Screening Tool for the Assessment of Malnutrition in Pediatrics (STAMP) is a validated tool for this purpose. The study aimed to modify STAMP for a Saudi context and assess the sensitivity and specificity of both the original and modified tools. Method: A cross-sectional study was conducted among 307 hospitalized children, where both the original and Saudi-modified STAMP were applied. Anthropometric measurements were also recorded, and statistical analysis using SPSS and validity parameters was used to assess the tools' validity. Results: The Saudi-modified STAMP identified a higher percentage of children at high risk of malnutrition compared to the original STAMP (91.6% vs. 62.9%). The sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and agreement of the Saudi-modified STAMP compared to the original were 94.3%, 13.2%, 64.8%, 57.7%, 0.654, and 0.089, respectively. Conclusions: The Saudi-modified STAMP showed excellent sensitivity and varied negative predictive value, indicating its potential effectiveness in screening for the risk of malnutrition among hospitalized children compared to the original STAMP. FAU - Alqahtani, Sheikha AU - Alqahtani S AUID- ORCID: 0000-0001-5143-6742 AD - Department of Community Health Sciences, Collage of Applied Medical Sciences, King Saud University, Riyadh 11451, Saudi Arabia. AD - Department of Dietetics, Prince Sultan Military Medical City, Riyadh 11159, Saudi Arabia. FAU - Aldubayan, Khalid AU - Aldubayan K AUID- ORCID: 0000-0002-0924-7400 AD - Department of Community Health Sciences, Collage of Applied Medical Sciences, King Saud University, Riyadh 11451, Saudi Arabia. FAU - Alshehri, Saleh AU - Alshehri S AD - Department of Emergency, Prince Sultan Military Medical City, Riyadh 11159, Saudi Arabia. FAU - Almuhareb, Ghada AU - Almuhareb G AD - Department of Dietetics, Prince Sultan Military Medical City, Riyadh 11159, Saudi Arabia. FAU - Mahnashi, Amal AU - Mahnashi A AD - Department of Community Health Sciences, Collage of Applied Medical Sciences, King Saud University, Riyadh 11451, Saudi Arabia. AD - Department of Clinical Nutrition, Riyadh Third Health Cluster, Riyadh 13717, Saudi Arabia. LA - eng PT - Journal Article DEP - 20241010 PL - Switzerland TA - Diagnostics (Basel) JT - Diagnostics (Basel, Switzerland) JID - 101658402 PMC - PMC11505708 OTO - NOTNLM OT - pediatric malnutrition OT - screening tools OT - validation COIS- The authors declare no conflicts of interest. EDAT- 2024/10/25 12:24 MHDA- 2024/10/25 12:25 PMCR- 2024/10/10 CRDT- 2024/10/25 09:55 PHST- 2024/09/27 00:00 [received] PHST- 2024/10/04 00:00 [revised] PHST- 2024/10/08 00:00 [accepted] PHST- 2024/10/25 12:25 [medline] PHST- 2024/10/25 12:24 [pubmed] PHST- 2024/10/25 09:55 [entrez] PHST- 2024/10/10 00:00 [pmc-release] AID - diagnostics14202256 [pii] AID - diagnostics-14-02256 [pii] AID - 10.3390/diagnostics14202256 [doi] PST - epublish SO - Diagnostics (Basel). 2024 Oct 10;14(20):2256. doi: 10.3390/diagnostics14202256. PMID- 39450267 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250206 IS - 2055-2238 (Electronic) IS - 2055-2238 (Linking) VI - 10 IP - 5 DP - 2024 Oct TI - Optimizing muscle preservation during weight loss in patients with cirrhosis: A pilot study comparing continuous energy restriction to alternate-day modified fasting for weight loss in patients with obesity and non-alcoholic cirrhosis of the liver. PG - e70016 LID - 10.1002/osp4.70016 [doi] LID - e70016 AB - INTRODUCTION: Obesity is associated with increased morbidity in patients with advanced liver disease, but it is particularly challenging for these patients to preserve skeletal muscle mass during weight loss and accelerating sarcopenia is a concern. Alternate-day modified fasting (ADMF) may be particularly effective for weight loss in patients with concomitant cirrhosis and obesity due to preservation of fat-free mass (FFM). METHODS: A weight loss program featuring either ADMF or a continuous low-calorie diet (LCD) was evaluated in a 24-week randomized clinical trial in 20 adult patients with Child-Pugh Class A cirrhosis and obesity. Participants were randomized to either ADMF (n = 11) or LCD (n = 9). Both groups received a remotely delivered exercise program. Body composition, sarcopenia measures, and functional outcomes were assessed pre-post. RESULTS: Thirteen participants completed the intervention (Age = 57 +/- 10; BMI = 37.7 +/- 5.8 kg/m(2)). The median body weight lost in ADMF was 13.7 +/- 4.8 kg (13.9% of initial body weight), while LCD lost 9.9 +/- 6.9 kg (10.7% of initial body weight). Total body fat percentage decreased in both groups (ADMF: -4.1 +/- 4.0%; LCD = -2.8 +/- 1.4%). Fat-free mass accounted for 34 +/- 20% of total weight loss in ADMF and 38 +/- 10% in LCD. Functional measures, such as timed chair stands, improved in both groups. CONCLUSION: This pilot study demonstrates the feasibility of the ADMF and LCD interventions to produce significant weight loss while improving body composition in patients with cirrhosis and obesity. Further research is needed to validate these findings in larger cohorts and to assess changes in muscle quality and visceral fat. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT05367596. CI - (c) 2024 The Author(s). Obesity Science & Practice published by World Obesity and The Obesity Society and John Wiley & Sons Ltd. FAU - Dunn, Winston AU - Dunn W AUID- ORCID: 0000-0002-4246-6998 AD - Division of Gastroenterology, Hepatology and Motility, Diabetes, and Clinical Pharmacology Department of Internal Medicine University of Kansas Medical Center Kansas City Kansas USA. FAU - Herrmann, Stephen D AU - Herrmann SD AUID- ORCID: 0000-0003-1933-5938 AD - Division of Physical Activity and Weight Management Department of Internal Medicine University of Kansas Medical Center Kansas City Kansas USA. FAU - Montgomery, Robert N AU - Montgomery RN AD - Department of Biostatistics and Data Science, Department of Internal Medicine University of Kansas Medical Center Kansas City Kansas USA. FAU - Hastert, Mary AU - Hastert M AD - Division of Physical Activity and Weight Management Department of Internal Medicine University of Kansas Medical Center Kansas City Kansas USA. FAU - Honas, Jeffery J AU - Honas JJ AD - Division of Physical Activity and Weight Management Department of Internal Medicine University of Kansas Medical Center Kansas City Kansas USA. FAU - Rachman, Jessica AU - Rachman J AD - Division of Gastroenterology, Hepatology and Motility, Diabetes, and Clinical Pharmacology Department of Internal Medicine University of Kansas Medical Center Kansas City Kansas USA. FAU - Donnelly, Joseph E AU - Donnelly JE AD - Division of Physical Activity and Weight Management Department of Internal Medicine University of Kansas Medical Center Kansas City Kansas USA. FAU - Steger, Felicia L AU - Steger FL AUID- ORCID: 0000-0002-8117-4082 AD - Division of Endocrinology, Diabetes, and Clinical Pharmacology, Department of Internal Medicine Department of Dietetics and Nutrition University of Kansas Medical Center Kansas City Kansas USA. LA - eng SI - ClinicalTrials.gov/NCT05367596 GR - P20 GM144269/GM/NIGMS NIH HHS/United States GR - UL1 TR002366/TR/NCATS NIH HHS/United States PT - Journal Article DEP - 20241024 PL - United States TA - Obes Sci Pract JT - Obesity science & practice JID - 101675151 PMC - PMC11500757 OTO - NOTNLM OT - body composition OT - cirrhosis OT - intermittent fasting OT - muscle OT - obesity OT - weight loss COIS- The authors declare no conflicts of interest. EDAT- 2024/10/25 10:52 MHDA- 2024/10/25 10:53 PMCR- 2024/10/24 CRDT- 2024/10/25 04:25 PHST- 2024/05/30 00:00 [received] PHST- 2024/07/10 00:00 [revised] PHST- 2024/10/03 00:00 [accepted] PHST- 2024/10/25 10:53 [medline] PHST- 2024/10/25 10:52 [pubmed] PHST- 2024/10/25 04:25 [entrez] PHST- 2024/10/24 00:00 [pmc-release] AID - OSP470016 [pii] AID - 10.1002/osp4.70016 [doi] PST - epublish SO - Obes Sci Pract. 2024 Oct 24;10(5):e70016. doi: 10.1002/osp4.70016. eCollection 2024 Oct. PMID- 39449948 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241026 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 16 IP - 9 DP - 2024 Sep TI - Assessment of Breastfeeding and Weaning Practices and Their Effects on Infant Growth in Western Maharashtra: A Cross-Sectional Study. PG - e70030 LID - 10.7759/cureus.70030 [doi] LID - e70030 AB - INTRODUCTION: Breastfeeding provides nutrients and antibodies crucial for developing infants and their immune systems. Understanding the current breastfeeding and weaning practices helps identify areas requiring improvements to boost infant health outcomes. The World Health Organization and other health bodies recommend that babies be exclusively breastfed for the first six months of life. Then, complementary feeding should be introduced along with breastfeeding, which should be continued for up to two years or more. OBJECTIVE: This study aims to analyze the perception and practices of breastfeeding and weaning among mothers with 9- to 12-month-old infants. METHODOLOGY: This cross-sectional analytical study was conducted at Krishna Hospital and Research Centre, Karad, for a period of six months. A validated questionnaire developed by investigators was used as the study tool. Mothers visiting the immunization clinics with their 9- to 12-month-old infants were enrolled in the study. Infants diagnosed as having inborn metabolic disorders, diabetes, heart diseases, and congenital malformations and those who were on special feeds or diets were not included in the study. RESULTS: The majority of the study participants (28 [33%]) initiated weaning when the infants were six to seven months of age, with the earliest being five months (8 [10%]). Five (6%) mothers could not initiate weaning until the infants were 12 months old. The most common weaning food was dal and rice with ghee (24 [29%]). A total of 50 (60%) participants used plastic bottles for feeding, and among them, 30 (36%) mothers used bottles to give water to their infants. A total of 23 (27%) participants did not feed their infants colostrum. The most common hunger cue was crying (82 [98%]), whereas the least common cue was mouth opening (8 [9%]). The incorrect practices followed by the mothers were late initiation of breastfeeding because of which colostrum could not be fed to the neonate; incorrect breastfeeding technique, that is, feeding little milk from each side of the breast without emptying one breast completely; late or no initiation of weaning foods; and offering less amount of weaning food than that required by the infant according to its nutritional demand. CONCLUSION: Initiating breastfeeding early and continuing breastfeeds along with complimentary feeds are essential for optimal infant growth. CI - Copyright (c) 2024, Dalbhanjan et al. FAU - Dalbhanjan, Josephine S AU - Dalbhanjan JS AD - Community and Family Medicine, Krishna Institute of Medical Sciences, Karad, IND. AD - Preventive and Social Medicine (PSM), Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND. FAU - Kadam, Yugantara AU - Kadam Y AD - Family Medicine, Krishna Institute of Medical Sciences, Karad, IND. AD - Preventive and Social Medicine (PSM), Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND. LA - eng PT - Journal Article DEP - 20240923 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC11499075 OTO - NOTNLM OT - breast milk OT - early nutrition OT - growth assessment OT - protein energy malnutrition (pem) OT - weaning food COIS- Human subjects: Consent was obtained or waived by all participants in this study. Institutional Ethical committee issued approval KIMSDU/IEC/03/2023. The IEC has given approval for the protocol number 553/2022-2023. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: SETS (Scholarly editing and translation services); Email: cs@editingindia.com; website: www.editingindia.com; Phone: +919987594481; Editing service quotation number: 205726. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2024/10/25 06:23 MHDA- 2024/10/25 06:24 PMCR- 2024/09/23 CRDT- 2024/10/25 04:18 PHST- 2024/06/07 00:00 [received] PHST- 2024/09/23 00:00 [accepted] PHST- 2024/10/25 06:24 [medline] PHST- 2024/10/25 06:23 [pubmed] PHST- 2024/10/25 04:18 [entrez] PHST- 2024/09/23 00:00 [pmc-release] AID - 10.7759/cureus.70030 [doi] PST - epublish SO - Cureus. 2024 Sep 23;16(9):e70030. doi: 10.7759/cureus.70030. eCollection 2024 Sep. PMID- 39448639 OWN - NLM STAT- MEDLINE DCOM- 20241025 LR - 20241028 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Oct 24 TI - Skeletal muscle size and quality in healthy kidney donors, normal range and clinical associations. PG - 25257 LID - 10.1038/s41598-024-76188-1 [doi] LID - 25257 AB - The gold standard to estimate muscle mass and quality is computed tomography (CT) scan. Lower mass and density (intramuscular fat infiltration) of skeletal muscles are markers of sarcopenia, associated with increased mortality risk, impaired physical function, and poorer prognosis across various populations and medical conditions. We aimed to describe standard reference values in healthy population, prospective kidney donors, and correlate clinical parameters to muscle mass and density. Included in the cohort 384 consecutive kidney donors. Mean age was 44.6 +/- 11.5 (range 18.4-74.2), 46% were female and mean BMI was 25.6 +/- 3.8 kg/m(2). Our quantified reference values for psoas cross -sectional area (CSA) index at L3 level (males/females respectively) were 6.3 +/- 1.8 and 4.8 +/- 1.9 cm(2) /m(2), and density was 46.1 +/- 5 and 41 +/- 5 HU at that level. Older age (standardized beta coefficient - 0.12, p = 0.04), sex (- 0.32, p < 0.001) and BMI (0.17, p = 0.002) were significantly associated with CSA index of psoas at L3. Density, however, was associated with triglycerides level (- 0.21, p < 0.001), in addition to age (- 0.22, p < 0.0001), sex (- 0.27, p < 0.001) and BMI (- 0.1, p = 0.05). Our study validates the normative values of psoas muscle mass and density in healthy individuals and suggests correlations with clinical parameters. We demonstrate the significance of measuring not only the mass of the muscle, but also its density, as it has a valid association with metabolic parameters, including BMI and lipid level, even in healthy individuals and in the normal range of the tests. CI - (c) 2024. The Author(s). FAU - Druckmann, Ido AU - Druckmann I AD - Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel. AD - Radiology Department, Tel-Aviv Medical Center, Tel Aviv, Israel. FAU - Schwartz, Doron AU - Schwartz D AD - Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel. AD - Nephrology Department, Tel Aviv Medical Center, Tel Aviv, Israel. FAU - Rotem, Nirit AU - Rotem N AD - Physiotherapy Department, Tel Aviv Medical Center, Tel Aviv, Israel. FAU - Khawaja, Jayan AU - Khawaja J AD - Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel. AD - Radiology Department, Tel-Aviv Medical Center, Tel Aviv, Israel. FAU - Graziani, Tamir AU - Graziani T AD - Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel. AD - Radiology Department, Tel-Aviv Medical Center, Tel Aviv, Israel. FAU - Saban, Mor AU - Saban M AD - Nursing Department, The Stanley Steyer School of Health Professions, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Kastner, James AU - Kastner J AD - Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel. FAU - Sher, Raz AU - Sher R AD - Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel. AD - Internal Medicine Department, Tel Aviv Medical Center, Tel Aviv, Israel. FAU - Goykhman, Yaacov AU - Goykhman Y AD - Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel. AD - Organ Transplantation Unit, Tel-Aviv Medical Center, Tel Aviv, Israel. FAU - Raz, Michal Ariela AU - Raz MA AD - Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel. AD - Nephrology Department, Tel Aviv Medical Center, Tel Aviv, Israel. AD - Organ Transplantation Unit, Tel-Aviv Medical Center, Tel Aviv, Israel. FAU - Shashar, Moshe AU - Shashar M AD - Nephrology Section, Laniado Hospital, Netanya, Israel. FAU - Cohen-Hagai, Keren AU - Cohen-Hagai K AD - Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel. AD - Department of Nephrology and Hypertension, Meir Medical Center, Kfar Saba, Israel. FAU - Nacasch, Naomi AU - Nacasch N AD - Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel. AD - Department of Nephrology and Hypertension, Meir Medical Center, Kfar Saba, Israel. FAU - Schwartz, Idit F AU - Schwartz IF AD - Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel. AD - Nephrology Department, Tel Aviv Medical Center, Tel Aviv, Israel. FAU - Grupper, Ayelet AU - Grupper A AD - Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel. ayeletg@tlvmc.gov.il. AD - Nephrology Department, Tel Aviv Medical Center, Tel Aviv, Israel. ayeletg@tlvmc.gov.il. AD - Organ Transplantation Unit, Tel-Aviv Medical Center, Tel Aviv, Israel. ayeletg@tlvmc.gov.il. LA - eng PT - Journal Article DEP - 20241024 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Male MH - Adult MH - Middle Aged MH - Aged MH - *Muscle, Skeletal/diagnostic imaging MH - *Tomography, X-Ray Computed MH - Young Adult MH - Reference Values MH - Kidney Transplantation MH - Adolescent MH - Sarcopenia/pathology/diagnostic imaging MH - Body Mass Index MH - Psoas Muscles/diagnostic imaging MH - Prospective Studies MH - Tissue Donors PMC - PMC11502878 OTO - NOTNLM OT - Living kidney donors OT - Muscle cross-sectional area OT - Muscle density OT - Myosteatosis OT - Sarcopenia COIS- The authors declare no competing interests. EDAT- 2024/10/25 06:23 MHDA- 2024/10/25 06:24 PMCR- 2024/10/24 CRDT- 2024/10/25 00:11 PHST- 2024/07/17 00:00 [received] PHST- 2024/10/11 00:00 [accepted] PHST- 2024/10/25 06:24 [medline] PHST- 2024/10/25 06:23 [pubmed] PHST- 2024/10/25 00:11 [entrez] PHST- 2024/10/24 00:00 [pmc-release] AID - 10.1038/s41598-024-76188-1 [pii] AID - 76188 [pii] AID - 10.1038/s41598-024-76188-1 [doi] PST - epublish SO - Sci Rep. 2024 Oct 24;14(1):25257. doi: 10.1038/s41598-024-76188-1. PMID- 39446733 OWN - NLM STAT- MEDLINE DCOM- 20250425 LR - 20250522 IS - 1533-4287 (Electronic) IS - 1064-8011 (Linking) VI - 38 IP - 12 DP - 2024 Dec 1 TI - Unveiling Gaps in High School Strength and Conditioning: CSCS Certification, Coaching Leadership, and Facilities. PG - 2088-2098 LID - 10.1519/JSC.0000000000004893 [doi] AB - Judge, LW, Marsh, JP, Petersen, JC, Pearson, D, and Bellar, D. Unveiling gaps in high school strength and conditioning: CSCS certification, coaching leadership and facilities. J Strength Cond Res 38(12): 2088-2098, 2024-The aim of this study was to examine the prevalence of Certified Strength and Conditioning Specialist (CSCS) and/or dedicated strength coaches overseeing strength and conditioning facilities (SCFs) at the high school level in a Southwestern state. An online survey, comprising 72 items based on a validated instrument, collected data on SCFs from high school athletic directors statewide. A total of 245 surveys were completed representing a 17.5% response rate. Descriptive, Pearson correlation, chi-square, and ANOVA analyses were conducted with an a priori alpha level of p < 0.05 established. The results revealed that only 9.4% of SCF supervisors held CSCS certification, 27.8% lacked certification, and 62.9% did not have a dedicated strength coach overseeing the SCF. Facilities led by CSCS coaches had several areas of greater equipment resources, including bench press stations ( F [2, 244] = 5.143, p = 0.006), squat stations ( F [2, 244] = 3.570, p = 0.030), and power clean stations ( F [2, 244] = 4.573, p = 0.011). This study highlights the importance of prioritizing safety considerations and meeting the developmental needs of high school athletes by addressing the absence of CSCS certifications and dedicated strength coaches overseeing SCFs. The scarcity of CSCS-credentialed coaches in high schools is troubling, considering adolescent athletes' developmental needs and recently enacted National Collegiate Athletic Association Division I safety standards for strength and conditioning coaches. CI - Copyright (c) 2024 National Strength and Conditioning Association. FAU - Judge, Lawrence W AU - Judge LW AD - Department of Social Work, Ball State University, Muncie, IN. FAU - Marsh, J Patrick AU - Marsh JP AD - Department of Kinesiology, Samford University, Homewood, AL. FAU - Petersen, Jeffrey C AU - Petersen JC AD - Department of Educational Leadership, Baylor University, Waco, TX. FAU - Pearson, David AU - Pearson D AD - School of Kinesiology, Ball State University, Muncie, IN; and. FAU - Bellar, David AU - Bellar D AD - Usha Kundu, MD College of Health, University of West Florida, Pensacola, FL. LA - eng PT - Journal Article DEP - 20241024 PL - United States TA - J Strength Cond Res JT - Journal of strength and conditioning research JID - 9415084 SB - IM MH - Humans MH - *Mentoring MH - *Certification/statistics & numerical data MH - *Leadership MH - *Schools MH - *Resistance Training/standards MH - Adolescent MH - *Physical Conditioning, Human MH - Surveys and Questionnaires EDAT- 2024/10/25 07:20 MHDA- 2025/01/14 18:21 CRDT- 2024/10/24 13:34 PHST- 2025/01/14 18:21 [medline] PHST- 2024/10/25 07:20 [pubmed] PHST- 2024/10/24 13:34 [entrez] AID - 00124278-202412000-00010 [pii] AID - 10.1519/JSC.0000000000004893 [doi] PST - ppublish SO - J Strength Cond Res. 2024 Dec 1;38(12):2088-2098. doi: 10.1519/JSC.0000000000004893. Epub 2024 Oct 24. PMID- 39446119 OWN - NLM STAT- MEDLINE DCOM- 20241219 LR - 20241219 IS - 1699-5198 (Electronic) IS - 0212-1611 (Linking) VI - 41 IP - 6 DP - 2024 Dec 19 TI - Reliability of the New Index of Global Food Quality and its relationship with sociodemographic variables and physical activity levels in the Chilean population. PG - 1265-1273 LID - 10.20960/nh.05192 [doi] AB - Introduction: surveys play a crucial role in evaluating the quality of food in populations, especially in healthcare settings, helping identify important characteristics of food descriptions and improving efficiency in the collection and management of data in dietary surveys. Objective: the primary aim of this study was to analyze the internal consistency of the New Index of Global Food Quality (NIGFQ) instrument and assess its applicability to sociodemographic variables and levels of physical activity (IPAQ-S) in a specific region of Chile. Methods: a descriptive, comparative, and correlational study that utilizes the online platform of Google Forms for data collection using the New Index of Global Food Quality (NIGFQ) and IPAQ-S instruments, in addition to considering sociodemographic variables, in a sample of 1,331 participants from the metropolitan region of Chile. Results: the study shows an improvement in the reliability of the NIGFQ (Cronbach's alpha: 0.63 to 0.71). Findings reveal significant inverse correlations between fruits (r = -0.31; p /=15 years with urinary measurements of nonpersistent EDCs, including bisphenol, triclosan, triclocarban, dichlorophenol, and paraben compounds were included in this study. Data were analyzed using the modified Poisson models to estimate the adjusted relative risk (RR) and 95% confidence interval (CI). The associations were also validated by considering TT and SHBG concentrations as the outcomes. The study included 1974 women with 11% high TT, 10.5% low SHBG, 40% obesity, and 46.2% MS. A medium to high exposure to bisphenol-A (RR = 1.64; 95% CI: 1.14, 2.35, p = 0.009), bisphenol-F (RR = 1.83; 95% CI: 1.35, 2.49, p < 0.001), bisphenol-S (RR = 1.83; 95% CI: 1.35, 2.49, p = 0.041) and 2, 4- dichlorophenol (RR = 1.61; 95% CI: 1.06, 2.45, p = 0.026) were associated with low SHBG but not with high TT. In addition, high exposure to triclosan was also inversely associated with SHBG concentrations (regression coefficient = -0.09; 95% CI: -0.15, -0.02, p = 0.013). However, these EDCs were found to be associated with SHBG, obesity, and MS according to menopausal status. High exposure to certain nonpersistent EDCs was associated with low SHBG, obesity, and MS according to menopausal status. FAU - Dubey, Pallavi AU - Dubey P AD - Department of Obstetrics and Gynecology, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, TX, USA. FAU - Reddy, Sireesha Y AU - Reddy SY AD - Department of Obstetrics and Gynecology, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, TX, USA. FAU - Thangavel, Chinthana AU - Thangavel C AD - Department of Medical Education, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, TX, USA. FAU - Hardy, Ghislain AU - Hardy G AD - Department of Obstetrics and Gynecology, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, TX, USA. FAU - Dwivedi, Alok Kumar AU - Dwivedi AK AD - Division of Biostatistics & Epidemiology, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, TX, USA. AD - Office of Research, Biostatistics and Epidemiology Consulting Lab, Texas Tech University Health Sciences Center El Paso, TX, USA. LA - eng PT - Journal Article DEP - 20241127 PL - England TA - J Investig Med JT - Journal of investigative medicine : the official publication of the American Federation for Clinical Research JID - 9501229 RN - 0 (Endocrine Disruptors) RN - 0 (Sex Hormone-Binding Globulin) RN - 0 (Gonadal Steroid Hormones) RN - 3XMK78S47O (Testosterone) SB - IM MH - Humans MH - Female MH - *Endocrine Disruptors/adverse effects/urine MH - Adult MH - Middle Aged MH - United States/epidemiology MH - Sex Hormone-Binding Globulin/metabolism MH - Metabolic Syndrome/epidemiology/chemically induced MH - *Gonadal Steroid Hormones/metabolism MH - *Environmental Exposure/adverse effects MH - Young Adult MH - Adolescent MH - Obesity/epidemiology MH - Testosterone/blood MH - Nutrition Surveys MH - Cross-Sectional Studies OTO - NOTNLM OT - Bisphenol OT - dichlorophenol OT - metabolic syndrome OT - obesity OT - paraben OT - sex hormones OT - triclosan COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2024/10/23 16:18 MHDA- 2025/02/11 12:24 CRDT- 2024/10/23 07:03 PHST- 2025/02/11 12:24 [medline] PHST- 2024/10/23 16:18 [pubmed] PHST- 2024/10/23 07:03 [entrez] AID - 10.1177/10815589241297724 [doi] PST - ppublish SO - J Investig Med. 2025 Feb;73(2):193-205. doi: 10.1177/10815589241297724. Epub 2024 Nov 27. PMID- 39439276 OWN - NLM STAT- MEDLINE DCOM- 20260511 LR - 20260511 IS - 1651-1905 (Electronic) IS - 1403-4948 (Linking) VI - 54 IP - 3 DP - 2026 May TI - Lifestyle factors as predictors of incident functional somatic disorder. Five-year follow-up of The DanFunD study. PG - 232-241 LID - 10.1177/14034948241283545 [doi] AB - AIMS: To assess whether lifestyle factors, including sleep pattern, are predictors for the development of functional somatic disorder (FSD). METHODS: A population-based prospective cohort of 9656 men and women aged 18-76 years was established in 2011-2015 and invited for re-examination in 2017-2020, when 5738 participated. Median follow-up period was 65 months. Participants filled in validated questionnaires on lifestyle, sleep pattern and various delimitations of FSD, which were operationalized using two different approaches: bodily distress syndrome (BDS) and functional somatic syndromes (FSS) (i.e. chronic fatigue, chronic widespread pain (CWP), irritable bowel, and multiple chemical sensitivity (MCS)). Baseline lifestyle and sleep pattern in relation to incidence of BDS and FSS (chronic fatigue, CWP, irritable bowel, MCS) was analysed by logistic regressions, adjusted for age, sex and subjective social status. RESULTS: Inferior sleep quality at baseline predicted both incidence of BDS and all FSS delimitations except MCS. Smoking, alcohol intake, and low physical activity, but not diet, were predictors for the development of BDS. No uniform pattern was observed for the FSS. Smoking predicted development of chronic fatigue, CWP and irritable bowel, but not MCS. Alcohol and food quality only influenced the development of chronic fatigue whereas low physical activity only influenced the development of chronic fatigue and CWP. CONCLUSIONS: Lifestyle factors and sleep pattern seem to be predictors for some delimitations of FSD, but the importance of the various lifestyle factors is different for the different delimitations. The study shows the importance of analysing the various FSSs separately. FAU - Jorgensen, Torben AU - Jorgensen T AUID- ORCID: 0000-0001-9453-2830 AD - Centre for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark. AD - Department of Public Health, Faculty of Health and Medical Science, University of Copenhagen, Denmark. FAU - Jacobsen, Rikke K AU - Jacobsen RK AD - Centre for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark. FAU - Weinreich Petersen, Marie AU - Weinreich Petersen M AD - Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital, Denmark. AD - Department of Clinical Medicine, University of Aarhus, Denmark. FAU - Bjerregaard, Anne A AU - Bjerregaard AA AD - Centre for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark. FAU - Ulfbeck Schovsbo, Signe AU - Ulfbeck Schovsbo S AUID- ORCID: 0000-0002-0206-8581 AD - Centre for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark. FAU - Gormsen, Lise K AU - Gormsen LK AD - Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital, Denmark. AD - Department of Clinical Medicine, University of Aarhus, Denmark. FAU - Falgaard Eplov, Lene AU - Falgaard Eplov L AD - Copenhagen Research Centre for Mental Health - CORE, Mental Health Centre Copenhagen, Copenhagen University Hospital, Denmark. FAU - Linneberg, Allan AU - Linneberg A AD - Centre for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark. AD - Department of Clinical Medicine, Faculty of Health and Medical Science, University of Copenhagen, Denmark. FAU - Fink, Per AU - Fink P AD - Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital, Denmark. AD - Department of Clinical Medicine, University of Aarhus, Denmark. FAU - Eriksen Benros, Michael AU - Eriksen Benros M AD - Copenhagen Research Centre for Mental Health - CORE, Mental Health Centre Copenhagen, Copenhagen University Hospital, Denmark. FAU - Dantoft, Thomas AU - Dantoft T AD - Centre for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark. LA - eng PT - Journal Article DEP - 20241022 PL - Sweden TA - Scand J Public Health JT - Scandinavian journal of public health JID - 100883503 SB - IM MH - Humans MH - Female MH - Male MH - Middle Aged MH - Adult MH - *Life Style MH - Follow-Up Studies MH - Incidence MH - Prospective Studies MH - Aged MH - Young Adult MH - Adolescent MH - Denmark/epidemiology MH - *Somatoform Disorders/epidemiology MH - Risk Factors MH - Surveys and Questionnaires OTO - NOTNLM OT - Functional somatic disorder OT - epidemiology OT - incidence OT - lifestyle OT - sleep pattern COIS- Declaration of conflicting interestsThe authors have no conflicts of interest to declare. EDAT- 2024/10/23 10:18 MHDA- 2026/05/11 13:00 CRDT- 2024/10/23 03:03 PHST- 2026/05/11 13:00 [medline] PHST- 2024/10/23 10:18 [pubmed] PHST- 2024/10/23 03:03 [entrez] AID - 10.1177/14034948241283545 [doi] PST - ppublish SO - Scand J Public Health. 2026 May;54(3):232-241. doi: 10.1177/14034948241283545. Epub 2024 Oct 22. PMID- 39438905 OWN - NLM STAT- MEDLINE DCOM- 20241023 LR - 20260923 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 Oct 22 TI - Relationship of the Prime Diet Quality Score (PDQS) and Healthy Eating Index (HEI-2015) with depression and anxiety: a cross-sectional study. PG - 2919 LID - 10.1186/s12889-024-20369-0 [doi] LID - 2919 AB - BACKGROUND: Previous studies have suggested a significant association between diet quality and mental health. However, a limited number of studies have utilized the Prime Diet Quality Score (PDQS) to examine this association. Additionally, no study has yet compared the PDQS and Healthy Eating Index-2015 (HEI-2015) in terms of their association with depression and anxiety. AIM: This cross-sectional study aimed to investigate the association between diet quality, measured by the PDQS and HEI-2015, and the odds of depression and anxiety in adults. METHODS: This study utilized data from the LIPOKAP study, which was conducted between February 2018 and July 2019 in five cities in Iran. We included 1994 adults aged 18 and above who were selected through a multistage cluster sampling method. Participants completed a validated semiquantitative food frequency questionnaire (FFQ) to evaluate their dietary intake. The FFQ was used to calculate the PDQS and HEI-2015. Depression and anxiety levels were determined using the Hospital Anxiety and Depression Scale (HADS). RESULTS: The participants had a mean age of 39.79 +/- 13.87 years, with females accounting for 1,041 (52.2%) of the total population. PDQS showed a significant inverse association with the odds of depression (OR = 0.45, 95% CI: 0.28-0.71) and anxiety (OR = 0.40, 95% CI: 0.25-0.62) in the fully adjusted model. Similarly, the highest quartile of HEI-2015 showed a significantly lower odds of depression (OR = 0.60, 95% CI: 0.40-0.90) and anxiety (OR = 0.62, 95% CI: 0.42-0.92) compared to the lowest quartile. CONCLUSION: Both PDQS and HEI-2015 were associated with a reduced risk of depression and anxiety. However, the PDQS demonstrated a stronger inverse association with these risks compared to the HEI-2015. This suggests that the PDQS could be a more beneficial dietary pattern for preventing depression and anxiety compared to HEI-2015. Further large-scale studies are required to confirm these findings. CI - (c) 2024. The Author(s). FAU - Ataei Kachouei, Amirhossein AU - Ataei Kachouei A AD - Interventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. AD - Faculty of Life Sciences: Food, Nutrition, and Health, University of Bayreuth, Kulmbach, Germany. FAU - Kamrani, Farzam AU - Kamrani F AD - Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Haghighatdoost, Fahimeh AU - Haghighatdoost F AD - Interventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. f_haghighatdoost@yahoo.com. AD - Interventional Cardiology Research Center, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. f_haghighatdoost@yahoo.com. FAU - Mohammadifard, Noushin AU - Mohammadifard N AD - Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. nmohammadifard@gmail.com. FAU - Najafi, Farid AU - Najafi F AD - Research Center for Environmental Determinants of Health, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. FAU - Farshidi, Hossein AU - Farshidi H AD - Hormozgan Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandarabbas, Iran. FAU - Lotfizadeh, Masoud AU - Lotfizadeh M AD - School of Health, Shahrekord University of Medical Sciences, Shahrekord, Iran. FAU - Kazemi, Tooba AU - Kazemi T AD - Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran. FAU - Karimi, Simin AU - Karimi S AD - Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Roohafza, Hamidreza AU - Roohafza H AD - Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Sabri, Mohammadreza AU - Sabri M AD - Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Sarrafzadegan, Nizal AU - Sarrafzadegan N AD - Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241022 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Male MH - Adult MH - *Depression/epidemiology MH - *Diet, Healthy/statistics & numerical data/psychology MH - Middle Aged MH - Iran/epidemiology MH - *Anxiety/epidemiology MH - Young Adult MH - Diet/statistics & numerical data/psychology MH - Adolescent MH - Surveys and Questionnaires MH - Diet Surveys PMC - PMC11494750 OTO - NOTNLM OT - Anxiety OT - Depression OT - Healthy eating index-2015 OT - Mental disorders OT - Prime diet quality score COIS- The authors declare no competing interests. EDAT- 2024/10/23 00:21 MHDA- 2024/10/23 10:18 PMCR- 2024/10/22 CRDT- 2024/10/23 00:00 PHST- 2024/06/07 00:00 [received] PHST- 2024/10/10 00:00 [accepted] PHST- 2024/10/23 10:18 [medline] PHST- 2024/10/23 00:21 [pubmed] PHST- 2024/10/23 00:00 [entrez] PHST- 2024/10/22 00:00 [pmc-release] AID - 10.1186/s12889-024-20369-0 [pii] AID - 20369 [pii] AID - 10.1186/s12889-024-20369-0 [doi] PST - epublish SO - BMC Public Health. 2024 Oct 22;24(1):2919. doi: 10.1186/s12889-024-20369-0. PMID- 39438830 OWN - NLM STAT- MEDLINE DCOM- 20241023 LR - 20260521 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 23 IP - 1 DP - 2024 Oct 22 TI - Relationship between emotional eating and nutritional intake in adult women with overweight and obesity: a cross-sectional study. PG - 129 LID - 10.1186/s12937-024-01030-3 [doi] LID - 129 AB - BACKGROUND: Emotional eating (EE) is particularly prevalent in overweight or obese women, who may turn to food as a way to cope with stress, sadness, or anxiety. Limited research has been conducted on the association between EE and nutritional intake. Therefore, present study was designed to explore this association in adult women with overweight and obesity. METHODS: In this cross-sectional study, the relationship between EE and nutritional intake in 303 overweight and obese women (aged 18-50 years) was examined. The researchers used the validated semi-quantitative Food Frequency Questionnaire (FFQ) to assess participants' nutritional intake and the Dutch Eating Behavior Questionnaire (DEBQ) to evaluate their eating behavior. To determine the association between EE and nutritional intake, we employed the multiple linear regression analysis. RESULTS: The frequency of high intensity EE was 64.4% among the study participants and the mean total score of EE subscale of DBEQ was 2.32 +/- 0.81. The total score of EE was positively associated with the energy intake (beta = 0.396, P = 0.007), even after adjusting for age and BMI. In addition, a significant inverse association was found between the score of EE and the daily intake of calcium (beta= -0.219, P = 0.026), riboflavin (beta= -0.166, P = 0.043), and vitamin B12 (beta= -0.271, P = 0.035), independent from energy and age. Also the results showed a significant positive association between the score of EE and the frequency of daily intake of cracker, muffin, cake, cream cake, pastry, candy, ice cream, pickles, melon, hydrogenated vegetable oil, peanut, salted and roasted seeds, and corn-cheese puff snack. CONCLUSION: This study found that overweight or obese women with higher intensity of EE might have a higher intake of energy and a lower intake of dietary calcium, riboflavin and vitamin B12. Integrating a balanced diet with psychotherapy is suggested to help individuals with EE reducing the urge to eat in response to emotions. CI - (c) 2024. The Author(s). FAU - Zare, Hadis AU - Zare H AD - Research Center for Biochemistry and Nutrition in Metabolic Diseases, Basic Science Research Institute, Kashan University of Medical Sciences, Kashan, 87159-73474, Iran. FAU - Rahimi, Habibollah AU - Rahimi H AD - Department of Epidemiology and Biostatistics, School of Health, Kashan University of Medical Sciences, Kashan, Iran. FAU - Omidi, Abdollah AU - Omidi A AD - Department of Clinical Psychology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran. FAU - Nematolahi, Faezeh AU - Nematolahi F AD - Research Center for Biochemistry and Nutrition in Metabolic Diseases, Basic Science Research Institute, Kashan University of Medical Sciences, Kashan, 87159-73474, Iran. AD - Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran. FAU - Sharifi, Nasrin AU - Sharifi N AD - Research Center for Biochemistry and Nutrition in Metabolic Diseases, Basic Science Research Institute, Kashan University of Medical Sciences, Kashan, 87159-73474, Iran. sharifi-na@kaums.ac.ir. LA - eng GR - 99210/Vice-Chancellor for Research and Technology of Kashan University of Medical Sciences, Kashan, Iran/ GR - 99210/Vice-Chancellor for Research and Technology of Kashan University of Medical Sciences, Kashan, Iran/ GR - 99210/Vice-Chancellor for Research and Technology of Kashan University of Medical Sciences, Kashan, Iran/ GR - 99210/Vice-Chancellor for Research and Technology of Kashan University of Medical Sciences, Kashan, Iran/ GR - 99210/Vice-Chancellor for Research and Technology of Kashan University of Medical Sciences, Kashan, Iran/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241022 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 RN - TLM2976OFR (Riboflavin) RN - 0 (Calcium, Dietary) SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Adult MH - Middle Aged MH - *Obesity/psychology MH - *Overweight/psychology MH - *Feeding Behavior/psychology MH - Young Adult MH - *Emotions MH - Adolescent MH - *Energy Intake MH - Surveys and Questionnaires MH - Diet/methods/statistics & numerical data/psychology MH - Body Mass Index MH - Eating/psychology MH - Riboflavin/administration & dosage MH - Calcium, Dietary/administration & dosage PMC - PMC11494802 OTO - NOTNLM OT - Emotional eating OT - Nutritional intake OT - Obesity OT - Overweight COIS- The authors declare no competing interests. EDAT- 2024/10/23 00:21 MHDA- 2024/10/23 07:19 PMCR- 2024/10/22 CRDT- 2024/10/22 23:56 PHST- 2024/01/13 00:00 [received] PHST- 2024/10/09 00:00 [accepted] PHST- 2024/10/23 07:19 [medline] PHST- 2024/10/23 00:21 [pubmed] PHST- 2024/10/22 23:56 [entrez] PHST- 2024/10/22 00:00 [pmc-release] AID - 10.1186/s12937-024-01030-3 [pii] AID - 1030 [pii] AID - 10.1186/s12937-024-01030-3 [doi] PST - epublish SO - Nutr J. 2024 Oct 22;23(1):129. doi: 10.1186/s12937-024-01030-3. PMID- 39438431 OWN - NLM STAT- MEDLINE DCOM- 20250311 LR - 20250516 IS - 2212-1358 (Electronic) IS - 2212-134X (Linking) VI - 13 IP - 2 DP - 2025 Mar TI - Gut microbiota alterations in adolescent idiopathic scoliosis: a comparison study with healthy control and congenital scoliosis. PG - 497-507 LID - 10.1007/s43390-024-00988-8 [doi] AB - PURPOSE: This study aims to compare the composition of GM isolated from individuals with AIS or congenital scoliosis (CS) and age-matched control (Ctr). METHODS: A total of 48 patients with AIS, 24 patients with CS, and 31 healthy individuals were recruited as the discovery cohort, and 9 pairs of siblings where one was affected by AIS were recruited as the validation cohort. The GM profile was determined with 16S rRNA sequencing, and the alpha-diversity and beta-diversity metrics were performed with Mothur. Linear discriminant analysis (LDA) analysis was performed to identify the enriched species. RESULTS: The alpha diversity (Chao1 index) was significantly lower in AIS patients with low BMI (< 18.5) than those with normal BMI. The PcoA analysis showed a trend of clustering of GM in AIS compared to that in Ctr and CS groups (r(2) = 0.0553, p = 0.001). METASTAT analysis showed Cellulomonadaceae was significantly enriched in AIS groups compared to CS and Ctr. LDA analysis showed 9 enriched species in AIS patients. Compared to Ctr, two species including Hungatella genus and Bacteroides fragilis were significantly enriched, while the Firmicutes versus Bacteroidetes (F/B) ratio and the Ruminococcus genus were significantly decreased in AIS but not CS groups. The significantly reduced F/B ratio and Ruminococcus genus in AIS were replicated in the validation cohort. CONCLUSIONS: Our study elucidated an association between low BMI and GM diversity in AIS patients. The reduced F/B ratio and Ruminococcus genus in AIS patients were identified and validated in 9 pairs of AIS patients and their unaffected siblings. Our pilot results may help understand the anthropometric discrepancy in these patients and support a possible role of GM in the pathogenesis of AIS. CI - (c) 2024. The Author(s), under exclusive licence to Scoliosis Research Society. FAU - Fang, Yinyu AU - Fang Y AUID- ORCID: 0009-0004-6559-2868 AD - Division of Spine Surgery, Department of Orthopaedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Zhongshan Road 321, Nanjing, 210008, China. FAU - Tian, Zhen AU - Tian Z AUID- ORCID: 0009-0006-3961-0668 AD - Division of Spine Surgery, Department of Orthopaedic Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, China. FAU - Li, Weibiao AU - Li W AD - Division of Spine Surgery, Department of Orthopaedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Zhongshan Road 321, Nanjing, 210008, China. FAU - Li, Dongyue AU - Li D AUID- ORCID: 0009-0009-3942-2298 AD - Division of Spine Surgery, Department of Orthopaedic Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China. FAU - Li, Jie AU - Li J AUID- ORCID: 0000-0003-1096-9328 AD - Division of Spine Surgery, Department of Orthopaedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Zhongshan Road 321, Nanjing, 210008, China. FAU - Hu, Zongshan AU - Hu Z AUID- ORCID: 0000-0002-9907-4389 AD - Division of Spine Surgery, Department of Orthopaedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Zhongshan Road 321, Nanjing, 210008, China. FAU - Qiu, Yong AU - Qiu Y AUID- ORCID: 0000-0002-2444-4744 AD - Division of Spine Surgery, Department of Orthopaedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Zhongshan Road 321, Nanjing, 210008, China. AD - Division of Spine Surgery, Department of Orthopaedic Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, China. AD - Division of Spine Surgery, Department of Orthopaedic Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China. FAU - Zhu, Zezhang AU - Zhu Z AUID- ORCID: 0000-0001-8569-3595 AD - Division of Spine Surgery, Department of Orthopaedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Zhongshan Road 321, Nanjing, 210008, China. AD - Division of Spine Surgery, Department of Orthopaedic Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, China. AD - Division of Spine Surgery, Department of Orthopaedic Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China. FAU - Liu, Zhen AU - Liu Z AUID- ORCID: 0000-0003-2027-8088 AD - Division of Spine Surgery, Department of Orthopaedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Zhongshan Road 321, Nanjing, 210008, China. drliuzhen@163.com. AD - Division of Spine Surgery, Department of Orthopaedic Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, China. drliuzhen@163.com. AD - Division of Spine Surgery, Department of Orthopaedic Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China. drliuzhen@163.com. LA - eng GR - 82072518/National Natural Science Foundation of China/ PT - Comparative Study PT - Journal Article DEP - 20241022 PL - England TA - Spine Deform JT - Spine deformity JID - 101603979 RN - 0 (RNA, Ribosomal, 16S) SB - IM MH - Humans MH - *Scoliosis/microbiology MH - Female MH - Male MH - *Gastrointestinal Microbiome/genetics/physiology MH - Adolescent MH - RNA, Ribosomal, 16S/genetics MH - Case-Control Studies MH - Child MH - Body Mass Index OTO - NOTNLM OT - A comparison study OT - Adolescent idiopathic scoliosis OT - Alterations OT - Gut microbiota COIS- Declarations. Conflict of interest: The authors have no financial or competing interests in relation to this work. Ethical approval and consent to participate: The study protocol was established and approved by the Clinical Research Ethics Committee of Nanjing Drum Tower hospital (2021-398-01). Written informed consent was obtained from patients. EDAT- 2024/10/23 00:21 MHDA- 2025/03/11 06:26 CRDT- 2024/10/22 23:17 PHST- 2024/06/03 00:00 [received] PHST- 2024/10/06 00:00 [accepted] PHST- 2025/03/11 06:26 [medline] PHST- 2024/10/23 00:21 [pubmed] PHST- 2024/10/22 23:17 [entrez] AID - 10.1007/s43390-024-00988-8 [pii] AID - 10.1007/s43390-024-00988-8 [doi] PST - ppublish SO - Spine Deform. 2025 Mar;13(2):497-507. doi: 10.1007/s43390-024-00988-8. Epub 2024 Oct 22. PMID- 39436394 OWN - NLM STAT- MEDLINE DCOM- 20250425 LR - 20260620 IS - 1550-9397 (Electronic) IS - 1550-9389 (Print) IS - 1550-9389 (Linking) VI - 21 IP - 2 DP - 2025 Feb 1 TI - Characteristics of clinical descriptive variables and polysomnographic findings of catathrenia. PG - 377-381 LID - 10.5664/jcsm.11434 [doi] AB - STUDY OBJECTIVES: Catathrenia has been classified as a sleep-related breathing disorder variant in the third edition of the International Classification of Sleep Disorders, but its validity remains unverified. We analyzed the clinical descriptive variables and polysomnographic findings of catathrenia and discussed the similarities to and differences from those of obstructive sleep apnea, non-rapid eye movement parasomnias, and sleep bruxism (SB). METHODS: A retrospective analysis was conducted on 47 patients diagnosed with nocturnal groaning through polysomnography. We examined sex, body mass index, age at symptom onset, weekly symptom frequency, and presence/absence of comorbidities, including obstructive sleep apnea, periodic limb movement disorder, non-rapid eye movement parasomnia, and SB. The groaning event index was calculated according to sleep position and sleep stage. RESULTS: The distribution of patients with catathrenia did not show sex differences (male/female = 20:27), body mass index was 20.6 +/- 3.0 kg/m(2), and age of onset was 18.2 +/- 7.4 years. The groaning event index was higher in stages N1 and R than in stage N3 and in the supine position than in the lateral position. There were no cases complicated with non-rapid eye movement parasomnia, but the complication of SB was observed in 30% of the participants, and SB events appeared immediately before or during the interictal period of the groaning event episodes in these cases. CONCLUSIONS: Given the clinical background, posture- and sleep stage-dependent appearance of groaning events, and the relatively high complication rate of SB, catathrenia pathogenesis may be heterogeneous or comprise elements of different sleep disorders. CITATION: Takei Y, Nakayama H, Inoue Y. Characteristics of clinical descriptive variables and polysomnographic findings of catathrenia. J Clin Sleep Med. 2025;21(2):377-381. CI - (c) 2025 American Academy of Sleep Medicine. FAU - Takei, Yoichiro AU - Takei Y AD - Yoyogi Sleep Disorder Center, Tokyo, Japan. AD - Japan Somnology Center, Neuropsychiatric Research Institute, Tokyo, Japan. FAU - Nakayama, Hideaki AU - Nakayama H AD - Yoyogi Sleep Disorder Center, Tokyo, Japan. AD - Japan Somnology Center, Neuropsychiatric Research Institute, Tokyo, Japan. AD - Department of Somnology, Tokyo Medical University, Tokyo, Japan. FAU - Inoue, Yuichi AU - Inoue Y AD - Yoyogi Sleep Disorder Center, Tokyo, Japan. AD - Japan Somnology Center, Neuropsychiatric Research Institute, Tokyo, Japan. AD - Department of Somnology, Tokyo Medical University, Tokyo, Japan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Switzerland TA - J Clin Sleep Med JT - Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine JID - 101231977 SB - IM MH - Humans MH - Male MH - Female MH - *Polysomnography/methods MH - Retrospective Studies MH - *Parasomnias/physiopathology/diagnosis MH - Adult MH - Adolescent MH - Young Adult MH - Sleep Apnea, Obstructive/physiopathology MH - Sleep Stages/physiology PMC - PMC11789240 OTO - NOTNLM OT - catathrenia OT - groaning events OT - obstructive sleep apnea OT - posture OT - sleep bruxism OT - sleep stage COIS- All authors have read and approved this manuscript. This work was performed at the Japan Somnology Center, Neuropsychiatric Research Institute. This was not an industry-supported study. Yoichiro Takei and Hideaki Nakayama report no conflicts of interest. Yuichi Inoue has received grants and research funding from Teijin Pharma Limited, Koike Medical Co. Ltd., and Phillips Japan Co. Ltd. EDAT- 2024/10/22 16:24 MHDA- 2025/02/03 12:22 PMCR- 2026/02/01 CRDT- 2024/10/22 10:53 PHST- 2025/02/03 12:22 [medline] PHST- 2024/10/22 16:24 [pubmed] PHST- 2024/10/22 10:53 [entrez] PHST- 2026/02/01 00:00 [pmc-release] AID - jcsm.11434 [pii] AID - JC2400299 [pii] AID - 10.5664/jcsm.11434 [doi] PST - ppublish SO - J Clin Sleep Med. 2025 Feb 1;21(2):377-381. doi: 10.5664/jcsm.11434. PMID- 39434064 OWN - NLM STAT- MEDLINE DCOM- 20241022 LR - 20250205 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 Oct 21 TI - Infant BMI trajectories as early risk markers of poor psychosocial health in preadolescence. PG - 2890 LID - 10.1186/s12889-024-19872-1 [doi] LID - 2890 AB - BACKGROUND: Common mental disorders often emerge during childhood and adolescence, and their prevalence is disproportionately elevated among those affected by obesity. Early life growth patterns may provide a useful target for primordial prevention; however, research is lacking. Therefore, this study aimed to identify distinct body mass index (BMI) trajectories during the first year of life and to assess their associations with psychosocial outcomes in preadolescence (9-13 years). METHODS: Data were obtained from n = 1778 Greek children (9-13 years). Infant anthropometric data were obtained from paediatric health records and BMI trajectories during the first year of life were estimated using group-based trajectory modelling. Preadolescent emotional functioning, self-esteem, body image dissatisfaction and dieting behaviours were self-reported via validated questionnaires. Associations were estimated using binary and ordinal logistic regression, adjusted for key confounders. RESULTS: Four BMI trajectories were identified: low (26.7%), average (41.8%), high (25.2%), and very high (6.4%). Children belonging to the very high trajectory had greater odds of body image dissatisfaction (OR: 1.62, 95%CI: 1.11, 2.38), dieting behaviour (OR: 1.49, 95%CI: 1.01, 2.20) and restrained eating (OR: 1.69 95%CI: 1.14, 2.52) than children belonging to the average trajectory. Body image dissatisfaction was also greater in children belonging to the high trajectory (OR: 1.40, 95%CI: 1.11, 1.76). However, infant BMI trajectories did not significantly predict childhood emotional functioning or self-esteem status. CONCLUSION: Infants with BMI growth in the high reference ranges had poorer psychosocial outcomes in preadolescence. Whilst further research is needed to replicate these findings, monitoring early infant growth trajectories may allow for early stratification of infants at risk of poor psychosocial outcomes. CI - (c) 2024. The Author(s). FAU - Gallagher, Claire AU - Gallagher C AD - Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia. FAU - Moschonis, George AU - Moschonis G AD - Department of Dietetics, Nutrition and Sport, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia. FAU - Lambert, Katrina AU - Lambert K AD - Department of Public Health, School of Psychology and Public Health, La Trobe University, Melbourne, Australia. FAU - Kanellakis, Spyridon AU - Kanellakis S AD - Department of Public Health, School of Psychology and Public Health, La Trobe University, Melbourne, Australia. FAU - Karaglani, Eva AU - Karaglani E AD - Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece. FAU - Mourouti, Niki AU - Mourouti N AD - Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece. AD - Department of Nutrition and Dietetics, Hellenic Mediterranean University, Sitia 723008, Crete, Greece. AD - Institute of Agri-food and Life Sciences, University Research & Innovation Center, Hellenic Mediterranean University, Crete, Greece. FAU - Anastasiou, Costas AU - Anastasiou C AD - Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece. FAU - Erbas, Bircan AU - Erbas B AD - Department of Public Health, School of Psychology and Public Health, La Trobe University, Melbourne, Australia. b.erbas@latrobe.edu.au. FAU - Manios, Yannis AU - Manios Y AD - Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241021 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - Male MH - Adolescent MH - *Body Mass Index MH - Child MH - Infant MH - *Self Concept MH - Greece/epidemiology MH - Risk Factors MH - Body Image/psychology PMC - PMC11492683 OTO - NOTNLM OT - BMI trajectories OT - Infant growth OT - Psychosocial health COIS- The authors declare no competing interests. EDAT- 2024/10/22 00:21 MHDA- 2024/10/22 07:26 PMCR- 2024/10/21 CRDT- 2024/10/21 23:48 PHST- 2023/12/12 00:00 [received] PHST- 2024/08/23 00:00 [accepted] PHST- 2024/10/22 07:26 [medline] PHST- 2024/10/22 00:21 [pubmed] PHST- 2024/10/21 23:48 [entrez] PHST- 2024/10/21 00:00 [pmc-release] AID - 10.1186/s12889-024-19872-1 [pii] AID - 19872 [pii] AID - 10.1186/s12889-024-19872-1 [doi] PST - epublish SO - BMC Public Health. 2024 Oct 21;24(1):2890. doi: 10.1186/s12889-024-19872-1. PMID- 39433922 OWN - NLM STAT- MEDLINE DCOM- 20241021 LR - 20241025 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Oct 21 TI - Clinical and dental predictors of preterm birth using machine learning methods: the MOHEPI study. PG - 24664 LID - 10.1038/s41598-024-75684-8 [doi] LID - 24664 AB - Preterm birth (PTB) is one of the most common and serious complications of pregnancy, leading to mortality and severe morbidities that can impact lifelong health. PTB could be associated with various maternal medical condition and dental status including periodontitis. The purpose of this study was to identify major predictors of PTB among clinical and dental variables using machine learning methods. Prospective cohort data were obtained from 60 women who delivered singleton births via cesarean section (30 PTB, 30 full-term birth [FTB]). Dependent variables were PTB and spontaneous PTB (SPTB). 15 independent variables (10 clinical and 5 dental factors) were selected for inclusion in the machine learning analysis. Random forest (RF) variable importance was used to identify the major predictors of PTB and SPTB. Shapley additive explanation (SHAP) values were calculated to analyze the directions of the associations between the predictors and PTB/SPTB. Major predictors of PTB identified by RF variable importance included pre-pregnancy body mass index (BMI), modified gingival index (MGI), preeclampsia, decayed missing filled teeth (DMFT) index, and maternal age as in top five rankings. SHAP values revealed positive correlations between PTB/SPTB and its major predictors such as premature rupture of the membranes, pre-pregnancy BMI, maternal age, and MGI. The positive correlations between these predictors and PTB emphasize the need for integrated medical and dental care during pregnancy. Future research should focus on validating these predictors in larger populations and exploring interventions to mitigate these risk factors. CI - (c) 2024. The Author(s). FAU - Park, Jung Soo AU - Park JS AD - Department of Periodontology, Korea University Anam Hospital, Seoul, Republic of Korea. FAU - Lee, Kwang-Sig AU - Lee KS AD - Center for Artificial Intelligence, Korea University College of Medicine, Seoul, Republic of Korea. FAU - Heo, Ju Sun AU - Heo JS AD - Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea. jesus82@snu.ac.kr. AD - Department of Pediatrics, Seoul National University Children's Hospital, 101 Daehak-Ro, Jongno-Gu, Seoul, 110-769, South Korea. jesus82@snu.ac.kr. AD - Department of Pediatrics, Korea University College of Medicine, Seoul, Republic of Korea. jesus82@snu.ac.kr. FAU - Ahn, Ki Hoon AU - Ahn KH AD - Department of Obstetrics and Gynecology, Gynecology, Korea University College of Medicine, Korea University Anam Hospital, 73 Goryeodae-Ro, Seongbuk-Gu, Seoul, 02841, Korea. akh1220@hanmail.net. LA - eng PT - Journal Article DEP - 20241021 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - *Premature Birth/epidemiology MH - Pregnancy MH - *Machine Learning MH - Adult MH - Risk Factors MH - Prospective Studies MH - Body Mass Index MH - Maternal Age MH - Periodontal Index MH - Infant, Newborn PMC - PMC11494142 OTO - NOTNLM OT - Artificial intelligence OT - Gingival index OT - Periodontitis OT - Preterm birth OT - Preterm labor COIS- The authors declare no competing interests. EDAT- 2024/10/22 00:21 MHDA- 2024/10/22 00:22 PMCR- 2024/10/21 CRDT- 2024/10/21 23:39 PHST- 2024/05/29 00:00 [received] PHST- 2024/10/07 00:00 [accepted] PHST- 2024/10/22 00:22 [medline] PHST- 2024/10/22 00:21 [pubmed] PHST- 2024/10/21 23:39 [entrez] PHST- 2024/10/21 00:00 [pmc-release] AID - 10.1038/s41598-024-75684-8 [pii] AID - 75684 [pii] AID - 10.1038/s41598-024-75684-8 [doi] PST - epublish SO - Sci Rep. 2024 Oct 21;14(1):24664. doi: 10.1038/s41598-024-75684-8. PMID- 39431956 OWN - NLM STAT- MEDLINE DCOM- 20241021 LR - 20241024 IS - 1751-1402 (Electronic) IS - 1381-4788 (Print) IS - 1381-4788 (Linking) VI - 30 IP - 1 DP - 2024 Dec TI - The development of a tool for GPs to manage overweight and obesity in children: A Delphi study. PG - 2413877 LID - 10.1080/13814788.2024.2413877 [doi] LID - 2413877 AB - BACKGROUND: General practitioners (GPs) could play an important role in the management of overweight and obesity in children. However, GPs experience different barriers and are in need of supportive tools. In order to support GPs to identify, address and refer these children, new tools should be developed. OBJECTIVE: To establish consensus among GPs about the content topics of a supportive tool to identify, address and refer children with overweight and obesity in general practice. METHODS: A two-round Delphi study was conducted with GPs identified as experts. A concept of a supportive tool was constructed based on focus-group interviews with GPs, practice nurses and parents of children with and without overweight and literature. The tool was categorised into five topics: identifying, initiating and continuing weight-related conversations, referring and evaluating a tool manual. GPs evaluated statements on the tool's topics in terms of importance. All statements were rated on a 5-point Likert scale and consensus was set at >/=70% of respondents agreeing with the statements. RESULTS: GPs agreed that a supportive tool must contain a child's specialised BMI calculator; examples to initiate and to continue weight-related conversations with parents and children; a map with available interventions; and a manual including information and resources about health risks of overweight and obesity during childhood. CONCLUSION: The content topics of a supportive tool for GPs to identify, discuss and refer children with overweight and obesity were determined through a consensus-driven process. Further validation and assessment are required through a feasibility and implementation study. FAU - van der Velden, Maxime Adriana Maria AU - van der Velden MAM AD - Department of General Practice, Erasmus MC Medical University Center Rotterdam, Rotterdam, The Netherlands. FAU - van Tilborg-den Boeft, Madelon AU - van Tilborg-den Boeft M AD - Department of General Practice, Erasmus MC Medical University Center Rotterdam, Rotterdam, The Netherlands. FAU - Buis, Sylvia AU - Buis S AD - Department of General Practice, Erasmus MC Medical University Center Rotterdam, Rotterdam, The Netherlands. FAU - Jansen, Wilma AU - Jansen W AD - Department of Public Health, Erasmus MC Medical University Center Rotterdam, Rotterdam, The Netherlands. AD - Department of Social Development, City of Rotterdam, Rotterdam, The Netherlands. FAU - Bindels, Patrick Jan Eugene AU - Bindels PJE AUID- ORCID: 0000-0001-5941-4820 AD - Department of General Practice, Erasmus MC Medical University Center Rotterdam, Rotterdam, The Netherlands. FAU - van Middelkoop, Marienke AU - van Middelkoop M AUID- ORCID: 0000-0001-6926-0618 AD - Department of General Practice, Erasmus MC Medical University Center Rotterdam, Rotterdam, The Netherlands. LA - eng PT - Journal Article DEP - 20241021 PL - England TA - Eur J Gen Pract JT - The European journal of general practice JID - 9513566 SB - IM MH - Humans MH - *Delphi Technique MH - *Pediatric Obesity/therapy MH - *General Practitioners MH - Child MH - Male MH - Female MH - *Focus Groups MH - Overweight/therapy MH - Referral and Consultation MH - General Practice/methods MH - Consensus MH - Body Mass Index MH - Adult MH - Parents MH - Middle Aged MH - Attitude of Health Personnel PMC - PMC11494705 OAB - General practitioners (GPs) are in need of support to manage overweight and obesity in children.This paper establishes the content topics of a supportive tool for GPs to identify, address and refer children with overweight and obesity.The feasibility of the supportive tool in daily general practice must be evaluated. OABL- eng OTO - NOTNLM OT - Children OT - Delphi study OT - general practice OT - obesity OT - overweight OT - tools COIS- All authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper. EDAT- 2024/10/21 16:17 MHDA- 2024/10/21 16:18 PMCR- 2024/10/21 CRDT- 2024/10/21 10:23 PHST- 2024/10/21 16:18 [medline] PHST- 2024/10/21 16:17 [pubmed] PHST- 2024/10/21 10:23 [entrez] PHST- 2024/10/21 00:00 [pmc-release] AID - 2413877 [pii] AID - 10.1080/13814788.2024.2413877 [doi] PST - ppublish SO - Eur J Gen Pract. 2024 Dec;30(1):2413877. doi: 10.1080/13814788.2024.2413877. Epub 2024 Oct 21. PMID- 39430060 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241023 IS - 2164-2850 (Electronic) IS - 2164-2850 (Linking) VI - 12 IP - 1 DP - 2024 TI - Factors influencing health-related quality of life of children with overweight and obesity in Kuala Lumpur, Malaysia. PG - 2413980 LID - 10.1080/21642850.2024.2413980 [doi] LID - 2413980 AB - INTRODUCTION: Overweight and obesity among children may have psychological consequences, with potentially lasting effects on health-related quality of life (HRQOL). The aims of this study were to compare HRQOL across weight status among children and to determine the factors influencing HRQOL among children with overweight and obesity. METHODS: This cross-sectional study involved school children aged 9-16 years that were recruited from eight randomly selected primary and secondary schools in Kuala Lumpur. The validated Malay version of Pediatric Quality of Life Inventory (PedsQL) was used to measure HRQOL. Complex sample general linear model was used to determine the significant factors associated with HRQOL among children with overweight and obesity. RESULTS: From 928 students, 41.2% (n = 375) of them had either overweight or obesity. Children with obesity reported lower overall HRQOL, physical functioning, social functioning, and psychosocial health summary, compared to normal weight children. In the final model, children with obesity had significantly lower HRQOL and physical functioning compared to children who were overweight, while those who lived with a single parent reported poorer HRQOL compared to children who lived with both parents. Children with history of being bullied had lower HRQOL and psychosocial health. Whereas those with lower self-esteem reported significantly lower scores in all three domains. CONCLUSION: Overweight and obesity have negative impacts on HRQOL of children. Among children with overweight and obesity, factors such as degree of obesity, family structure, history of being bullied, and self-esteem were found to be significantly associated with HRQOL. Therefore, assessing and managing HRQOL should be included as a part of the obesity prevention programme. CI - (c) 2024 Ministry of Health Malaysia. Published by Informa UK Limited, trading as Taylor & Francis Group. FAU - Abdullah, Shazana Rifham AU - Abdullah SR AD - Nutrition, Metabolism and Cardiovascular Research Centre, Institute for Medical Research, National Institute of Health, Ministry of Health, Selangor, Malaysia. FAU - Victor Chee Wai, Hoe AU - Victor Chee Wai H AD - Department of Social and Preventive Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia. FAU - Ishak, Zahari AU - Ishak Z AD - Department of Educational Psychology and Counseling, Faculty of Education, Universiti Malaya, Kuala Lumpur, Malaysia. FAU - Hamzah, Siti Sarah AU - Hamzah SS AD - Nutrition, Metabolism and Cardiovascular Research Centre, Institute for Medical Research, National Institute of Health, Ministry of Health, Selangor, Malaysia. FAU - Nur Zati Iwani, Ahmad Kamil AU - Nur Zati Iwani AK AD - Nutrition, Metabolism and Cardiovascular Research Centre, Institute for Medical Research, National Institute of Health, Ministry of Health, Selangor, Malaysia. FAU - Wan Mohd Zin, Ruziana Mona AU - Wan Mohd Zin RM AD - Nutrition, Metabolism and Cardiovascular Research Centre, Institute for Medical Research, National Institute of Health, Ministry of Health, Selangor, Malaysia. FAU - Yahya, Abqariyah AU - Yahya A AD - Department of Social and Preventive Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia. LA - eng PT - Journal Article DEP - 20241016 PL - England TA - Health Psychol Behav Med JT - Health psychology and behavioral medicine JID - 101624393 PMC - PMC11488170 OTO - NOTNLM OT - Health-related quality of life OT - adolescents OT - children OT - obesity OT - overweight COIS- No potential conflict of interest was reported by the author(s). EDAT- 2024/10/21 10:51 MHDA- 2024/10/21 10:52 PMCR- 2024/10/16 CRDT- 2024/10/21 05:36 PHST- 2024/10/21 10:52 [medline] PHST- 2024/10/21 10:51 [pubmed] PHST- 2024/10/21 05:36 [entrez] PHST- 2024/10/16 00:00 [pmc-release] AID - 2413980 [pii] AID - 10.1080/21642850.2024.2413980 [doi] PST - epublish SO - Health Psychol Behav Med. 2024 Oct 16;12(1):2413980. doi: 10.1080/21642850.2024.2413980. eCollection 2024. PMID- 39429551 OWN - NLM STAT- MEDLINE DCOM- 20241021 LR - 20241023 IS - 1937-8688 (Electronic) VI - 48 DP - 2024 TI - Body composition analysis using bioelectric impedance in Bissau: reproducibility and level of agreement between two available devices. PG - 80 LID - 10.11604/pamj.2024.48.80.42997 [doi] LID - 80 AB - INTRODUCTION: the need to correctly measure and follow body composition as a simple disease prevention metric is important, especially where the healthcare infrastructures are poor. The variety of inexpensive devices available for this purpose is large. However, it is imperative to validate them in relation to the gold standard method, dual-energy absorptiometry X-ray (DEXA). In low-income countries, DEXA measurements aren't available. Thus, easy-to-use, and accurate devices are indispensable. In Guinea-Bissau, two relatively inexpensive, bioelectrical impedance scales, simple to use, are available. However, their accuracy has not been assessed in this setting. The study compares the level of agreement in measurements between, the Tanita(R) BC-545 and the Omron Karada Scan BF511, in adult volunteers. METHODS: volunteers grouped for athletic and sports modalities at stadiums and sports facilities in Bissau were included. All anthropometric measurements were done in both devices. For statistical analysis, we created Bland-Altman plots to assess their level of agreement. RESULTS: the study included 274 participants, mean age 27.4 years, 214 (78%) males. For body fat, the median between the Omron and Tanita measures was 2.6 and the interquartile was 5.2. The Omron measured median body mass index, -0.3 kg/m(2) and 0.8 kg/m(2) of interquartile below that of the Tanita. For visceral fat, the Omron measured 1% of median and an interquartile of 2% above that of the Tanita. For skeletal muscle, the Omron median measured 11.3% and 11.4 % of interquartile below that of the Tanita. The intra-class correlation coefficient (ICC) for body fat (BF), body mass index (BMI) and skeletal muscle (SM) was 0.99 and for VF it was 1.00 on both devices. CONCLUSION: the results indicate a good level of agreement between the two devices. In resource-limited settings, the Omron is likely a reasonable substitute for more expensive body composition devices. CI - Copyright: Lilica Sanca et al. FAU - Sanca, Lilica AU - Sanca L AD - Faculty of Sport Sciences and Physical Education, University of Coimbra, CIDAF-Research Center for Sport and Physical Activity, Coimbra, Portugal. AD - Center for Neuroscience and Cell Biology, Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal. AD - National Institute of Health, National Public Health Laboratory, Bissau, Guinea-Bissau. AD - Bandim Health Project, Bissau, Guinea-Bissau. FAU - Byberg, Stine AU - Byberg S AD - Steno Diabetes Center Copenhagen (SDCC), Herlev, Denmark. FAU - Co, Cipriano AU - Co C AD - Faculdade de Motricidade Humana (UTL-FMH), Exercise and Health by Universidade Tecnica de Lisboa, Bissau, Guinea-Bissau. FAU - da Costa, Geovane AU - da Costa G AD - Institute of Hygiene and Tropical Medicine, New University of Lisbon, Lisbon, Portugal. FAU - Indami, Marceano AU - Indami M AD - National Diabetes Association (ANDD) and National Diabetes Clinic (CND), Bissau, Guinea-Bissau. FAU - Rama, Luis AU - Rama L AD - Faculty of Sport Sciences and Physical Education, University of Coimbra, CIDAF-Research Center for Sport and Physical Activity, Coimbra, Portugal. FAU - Teixeira, Ana Maria AU - Teixeira AM AD - Faculty of Sport Sciences and Physical Education, University of Coimbra, CIDAF-Research Center for Sport and Physical Activity, Coimbra, Portugal. FAU - Bjerregaard-Andersen, Morten AU - Bjerregaard-Andersen M AD - Bandim Health Project, Bissau, Guinea-Bissau. AD - Department of Endocrinology and Nephrology, University Hospital of Southwest Denmark, Finsensgade, Denmark. FAU - Carvalho, Eugenia AU - Carvalho E AD - Center for Neuroscience and Cell Biology, Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal. AD - Institute of Interdisciplinary Research, University of Coimbra, Coimbra, Portugal. LA - eng PT - Comparative Study PT - Journal Article DEP - 20240628 PL - Uganda TA - Pan Afr Med J JT - The Pan African medical journal JID - 101517926 SB - IM MH - Humans MH - *Electric Impedance MH - *Body Composition/physiology MH - Male MH - Adult MH - Female MH - Reproducibility of Results MH - Guinea-Bissau MH - Young Adult MH - Anthropometry/methods MH - Absorptiometry, Photon MH - Adipose Tissue MH - Middle Aged MH - Adolescent MH - Cross-Sectional Studies PMC - PMC11489744 OTO - NOTNLM OT - Bioelectrical impedance OT - Guinea-Bissau OT - Omron OT - Tanita OT - body composition COIS- The authors declare no competing interests. EDAT- 2024/10/21 10:51 MHDA- 2024/10/21 13:21 PMCR- 2024/06/28 CRDT- 2024/10/21 05:28 PHST- 2024/02/18 00:00 [received] PHST- 2024/05/02 00:00 [accepted] PHST- 2024/10/21 13:21 [medline] PHST- 2024/10/21 10:51 [pubmed] PHST- 2024/10/21 05:28 [entrez] PHST- 2024/06/28 00:00 [pmc-release] AID - PAMJ-48-80 [pii] AID - 10.11604/pamj.2024.48.80.42997 [doi] PST - epublish SO - Pan Afr Med J. 2024 Jun 28;48:80. doi: 10.11604/pamj.2024.48.80.42997. eCollection 2024. PMID- 39428068 OWN - NLM STAT- MEDLINE DCOM- 20241205 LR - 20260512 IS - 1541-6100 (Electronic) IS - 0022-3166 (Linking) VI - 154 IP - 12 DP - 2024 Dec TI - Associations of Pregnancy Dietary Quality and Diversity with Childhood Celiac Disease. PG - 3770-3779 LID - S0022-3166(24)01110-6 [pii] LID - 10.1016/j.tjnut.2024.10.033 [doi] AB - BACKGROUND: High gluten and low dietary fiber in pregnancy intake is associated with an increased risk of celiac disease (CeD) in the child. Early life higher dietary quality is suggested to reduce the subsequent risk of CeD. OBJECTIVES: The aim was to investigate associations of pregnancy dietary quality and diversity with child risk of CeD. METHODS: In The Norwegian Mother, Father and Child Cohort Study, 85,122 mother-child pairs had available data from a validated pregnancy food frequency questionnaire. Pregnancy dietary quality and diversity were estimated by a Pregnancy Healthy Eating Index [mean 99.3, standard deviation (SD) 9.9, range 48.8-128.3], and a Diet Diversity Score (mean 7.0, SD 1.0, range 1.6-9.8), respectively. Child CeD was captured by >/=2 diagnostic codes in the Norwegian Patient Registry. Logistic regression was used to estimate associations between pregnancy dietary quality, diversity and child CeD, adjusted for socioeconomic factors, and parents CeD [adjusted odds ratio (aOR), 95% confidence intervals (CI)]. CeD-susceptible human leukocyte antigen haplotypes (DQ2/DQ8) were present in 30,718 (45.5%). RESULTS: Up to mean age 16.0 (SD 1.8, 12.4-19.8) y, 1363 (1.6%) children were diagnosed with CeD. Lower as well as higher pregnancy dietary quality associated with a reduced risk of CeD in the child (<5th percentile aOR = 0.67, 95% CI: 0.48, 0.93, >95th percentile aOR = 0.71, 95% CI: 0.52, 0.98, respectively, nonlinear squared term P = 0.011). Analyses on genetically susceptible children, adjustments for pregnancy iron supplementation, gluten, and dietary fiber intake, and child early life dietary quality, gluten intake and iron supplementation, supported the finding. Pregnancy dietary diversity was not associated with child CeD (aOR = 1.00, 95% CI: 0.94, 1.07/score). CONCLUSIONS: In this population-based study, lower as well as higher pregnancy dietary quality associated with a reduced risk of CeD diagnosis in the child. In contrast, no such association was observed with maternal dietary diversity. CI - Copyright (c) 2024 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Hard Af Segerstad, Elin M AU - Hard Af Segerstad EM AD - Department of Pediatric Research, Oslo University Hospital, Oslo, Norway; Unit for Celiac and Diabetes Research, Clinical Sciences, Lund University, Malmoe, Sweden. Electronic address: elin.malmberg_hard_af_segerstad@med.lu.se. FAU - Borge, Tiril Cecilie AU - Borge TC AD - Cluster for Reviews and Health Technology Assessments, Norwegian Institute of Public Health, Oslo, Norway. FAU - Guo, Annie AU - Guo A AD - Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Marild, Karl AU - Marild K AD - Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Pediatrics, Queen Silvia Children's Hospital, Gothenburg, Sweden. FAU - Stene, Lars C AU - Stene LC AD - Cluster for Reviews and Health Technology Assessments, Norwegian Institute of Public Health, Oslo, Norway. FAU - Brantsaeter, Anne Lise AU - Brantsaeter AL AD - Department of Food Safety, Center for Sustainable Diets, Norwegian Institute of Public Health, Oslo, Norway. FAU - Stordal, Ketil AU - Stordal K AD - Department of Pediatric Research, Oslo University Hospital, Oslo, Norway; Faculty of Clinical Medicine, University of Oslo, Oslo, Norway. CN - HEDIMED Investigator Group LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241018 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 RN - 0 (Dietary Fiber) SB - IM MH - Humans MH - *Celiac Disease/genetics MH - Female MH - Pregnancy MH - *Diet MH - Adolescent MH - Norway MH - Cohort Studies MH - Male MH - Adult MH - Dietary Fiber/administration & dosage MH - Child MH - Maternal Nutritional Physiological Phenomena OTO - NOTNLM OT - Dietary Diversity Score OT - HLA DQ2 DQ8 OT - Healthy Eating Index OT - The Norwegian Mother, Father, and Child Cohort study OT - food frequency questionnaire COIS- Conflict of interest The authors have no conflicts of interest relevant to this article to disclose. EDAT- 2024/10/21 10:48 MHDA- 2024/12/06 05:30 CRDT- 2024/10/20 19:22 PHST- 2024/07/01 00:00 [received] PHST- 2024/10/09 00:00 [revised] PHST- 2024/10/15 00:00 [accepted] PHST- 2024/12/06 05:30 [medline] PHST- 2024/10/21 10:48 [pubmed] PHST- 2024/10/20 19:22 [entrez] AID - S0022-3166(24)01110-6 [pii] AID - 10.1016/j.tjnut.2024.10.033 [doi] PST - ppublish SO - J Nutr. 2024 Dec;154(12):3770-3779. doi: 10.1016/j.tjnut.2024.10.033. Epub 2024 Oct 18. PMID- 39427088 OWN - NLM STAT- MEDLINE DCOM- 20241114 LR - 20241218 IS - 1573-6628 (Electronic) IS - 1092-7875 (Print) IS - 1092-7875 (Linking) VI - 28 IP - 12 DP - 2024 Dec TI - Reliability of Parental Recall of Birth Weight, Birth Length and Gestational Age in the Multicenter Cohort Study IDEFICS. PG - 2071-2085 LID - 10.1007/s10995-024-04009-y [doi] AB - OBJECTIVE: To investigate the reliability of parental recall of birth weight, birth length and gestational age several years after birth. METHODS: Parentally recalled birth parameters were obtained from the European multicentric cohort study IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) and compared to the corresponding data externally recorded in the child's medical check-up booklet. The agreement between the two sources was examined using Bland-Altman plots, intraclass correlation coefficients and Cohen's kappa for clinically relevant categories. Additionally, logistic regression models were used to identify factors related to parental recall accuracy. RESULTS: A total of 4930 children aged 2 to 11 years were included. Accuracy of birth weight within 100 g was 88%, 94% of the recalled birth length was within 2 cm, and 99% of the parents could recall with 2 weeks accuracy how many weeks their child was delivered preterm. Discrepancies of more than two weeks or more than 100 g were more likely in parents of low or medium socioeconomic status. Non-biological parents were 3.4 times more likely to have a discrepancy of more than 100 g compared to biological mothers (95% CI 1.7-6.7). Moreover, parents were less likely to accurately recall their child's birth parameters with increasing number of children within a family. CONCLUSIONS FOR PRACTICE: In general, parents' information matched well with the medical check-up booklet. However, accuracy varied among different groups which should be taken into consideration when using birth data recalled by parents in studies of child health. CI - (c) 2024. The Author(s). FAU - Swenne, Annika AU - Swenne A AUID- ORCID: 0009-0004-8743-3913 AD - Leibniz Institute for Prevention Research and Epidemiology-BIPS, Achterstrasse 30, 28359, Bremen, Germany. swenne@leibniz-bips.de. FAU - Veidebaum, Toomas AU - Veidebaum T AD - Department of Chronic Diseases, National Institute for Health Development, Hiiu 42, 11619, Tallinn, Estonia. FAU - Tornaritis, Michael AU - Tornaritis M AD - Research and Education Institute of Child Health, 138, Limassol Ave, #205, 2015, Strovolos, Cyprus. FAU - Dello Russo, Marika AU - Dello Russo M AD - Institute of Food Sciences, National Research Council, Via Roma, 52 A/C, 83100, Avellino, Italy. FAU - Moreno, Luis A AU - Moreno LA AD - GENUD (Growth, Exercise, Nutrition and Development) Research Group, University of Zaragoza, Pedro Cerbuna, 12, 50009, Saragossa, Spain. AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de La Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Monforte de Lemos 3-5. Pabellon 11. Planta 0, 28029, Madrid, Spain. AD - Instituto Agroalimentario de Aragon (IA2), Calle Miguel Servet, 177, 50013, Saragossa, Spain. AD - Instituto de Investigacion Sanitaria Aragon (IIS Aragon), Avda. San Juan Bosco, 13, 50009, Saragossa, Spain. FAU - Molnar, Denes AU - Molnar D AD - Department of Pediatrics, Medical School, University of Pecs, Szigeti Str 12, 7624, Pecs, Hungary. FAU - Marild, Staffan AU - Marild S AD - Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy at Gothenburg University, Box 100, 40530, Gothenburg, Sweden. FAU - De Henauw, Stefaan AU - De Henauw S AD - Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Corneel Heymanslaan 10, 9000, Ghent, Belgium. FAU - Pigeot, Iris AU - Pigeot I AD - Leibniz Institute for Prevention Research and Epidemiology-BIPS, Achterstrasse 30, 28359, Bremen, Germany. AD - Faculty of Mathematics and Computer Science, University of Bremen, Post Office Box 330440, 28334, Bremen, Germany. FAU - Pohlabeln, Hermann AU - Pohlabeln H AD - Leibniz Institute for Prevention Research and Epidemiology-BIPS, Achterstrasse 30, 28359, Bremen, Germany. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20241019 PL - United States TA - Matern Child Health J JT - Maternal and child health journal JID - 9715672 SB - IM MH - Adult MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant, Newborn MH - Male MH - *Birth Weight MH - Body Height MH - Cohort Studies MH - *Gestational Age MH - *Mental Recall MH - *Parents/psychology MH - Reproducibility of Results PMC - PMC11564252 OTO - NOTNLM OT - Birth length OT - Birth weight OT - Gestational age OT - Parental recall OT - Reliability COIS- Declarations Conflict of interest The authors declare that they have no competing interests. Ethical Approval The study has been approved by the appropriate institutional review boards of all eight study centers (1. Belgium: Ethics Committee of the Gent University Hospital, 15/10/2007, ref: No. EC UZG 2007/243 and 19/02/2013, No. B670201316342; 2. Cyprus: Cyprus National Bioethics Committee, 12/07/2007, ref: No. EEBK/EM/2007/16 and 21/Feb/2013, No. EEBK/ETI/2012/33; 3. Estonia: Tallinn Medical Research Ethics Committee (TMREC), 14/06/2007, ref: No. 1093 and 17/January 2013, No. 128; 4. Germany: Ethic Commission of the University of Bremen, 16/01/2007 and 11/12/2012; 5. Hungary: Medical Research Council, 21/Jun/2007, ref: 22-156/2007-1018EKU and 18/12/2012, 4536/2013/EKU; 6. Italy: Ethics Committee of the Local Health Authority (ASL) in Avellino, 19/06/2007, ref: No. 2/CE and 18/Sep/2012, No. 12/12; 7. Spain: Ethics Committee for Clinical Research of Aragon (CEICA), 20/06/2007, ref: No. PI07/13 and 13/Feb/2013, No. PI13/0012; 8. Sweden: Regional Ethics Research Board in Gothenburg, 30/07/2007, ref: No. 264-07 and 10/Jan/2013, No. 927-12). The study has been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Consent to Participate Informed consent was obtained from all individual participants included in the study. Before children entered the study, parents provided written informed consent. Additionally, children gave oral consent for examinations and sample collection. Consent for Publication Not applicable. EDAT- 2024/10/20 00:42 MHDA- 2024/11/14 18:31 PMCR- 2024/10/19 CRDT- 2024/10/19 23:28 PHST- 2024/09/29 00:00 [accepted] PHST- 2024/11/14 18:31 [medline] PHST- 2024/10/20 00:42 [pubmed] PHST- 2024/10/19 23:28 [entrez] PHST- 2024/10/19 00:00 [pmc-release] AID - 10.1007/s10995-024-04009-y [pii] AID - 4009 [pii] AID - 10.1007/s10995-024-04009-y [doi] PST - ppublish SO - Matern Child Health J. 2024 Dec;28(12):2071-2085. doi: 10.1007/s10995-024-04009-y. Epub 2024 Oct 19. PMID- 39426314 OWN - NLM STAT- MEDLINE DCOM- 20241130 LR - 20241130 IS - 1879-1506 (Electronic) IS - 0003-9969 (Linking) VI - 169 DP - 2025 Jan TI - Masticatory function and three-dimensional facial morphology of soft tissues: One year after orthognathic surgery. PG - 106103 LID - S0003-9969(24)00224-3 [pii] LID - 10.1016/j.archoralbio.2024.106103 [doi] AB - OBJECTIVE: Dentofacial deformities (DFD) require orthodontic treatment, orthognathic surgery, and speech therapy for aesthetic and functional problems. This longitudinal study analyzed changes in masticatory function and three-dimensional (3D) facial soft tissue in patients with Class II and Class III DFD after orthognathic surgery. In addition, the study investigated the relationship between facial measurements, maximum bite force (MBF), and orofacial myofunctional status (OMS). DESIGN: The sample consisted of 46 participants, including 10 patients with Class II DFD, and 11 patients with Class III DFD. These groups were assessed before (T0) and 6 months (T1) after surgery. Twelve patients who completed the treatment protocol were evaluated 12 months post-surgery (T2). The patient groups were compared with each other and with a control group (CG) of 25 healthy subjects. The participants underwent MBF and clinical evaluation of OMS, including masticatory behavior, using a validated protocol. The 3D facial soft tissue was assessed using laser scanning. RESULTS: Compared to the CG, DFD patients showed reduced MBF, masticatory behavior, and OMS scores at T0. At T2, there was an improvement in MBF, masticatory, and OMS scores, but differences were observed compared to the CG. Changes in facial soft tissue followed the underlying hard tissue movement resulting from surgery, and reduction of vertical measurements contributed to improvements in masticatory function. CONCLUSION: These findings indicated that combined surgery, orthodontic treatment, and speech therapy can lead to a significant improvement in masticatory function and facial soft tissue in DFD patients, although not completely 12 months post-surgery. CI - Copyright (c) 2024 Elsevier Ltd. All rights reserved. FAU - Simoes, Joana Carolina Martins AU - Simoes JCM AD - Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery, Ribeirao Preto Medical School, University of Sao Paulo, Av. dos Bandeirantes 3900, Ribeirao Preto, SP ZIP 14049-900, Brazil; Craniofacial Research Support Center, University of Sao Paulo, Av. dos Bandeirantes 3900, Ribeirao Preto, SP ZIP 14049-900, Brazil. Electronic address: joanasimoesphd@gmail.com. FAU - Garcia, Denny Marcos AU - Garcia DM AD - Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery, Ribeirao Preto Medical School, University of Sao Paulo, Av. dos Bandeirantes 3900, Ribeirao Preto, SP ZIP 14049-900, Brazil; Craniofacial Research Support Center, University of Sao Paulo, Av. dos Bandeirantes 3900, Ribeirao Preto, SP ZIP 14049-900, Brazil. Electronic address: dmgarcia@fmrp.usp.br. FAU - De Mello-Filho, Francisco Verissimo AU - De Mello-Filho FV AD - Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery, Ribeirao Preto Medical School, University of Sao Paulo, Av. dos Bandeirantes 3900, Ribeirao Preto, SP ZIP 14049-900, Brazil; Craniofacial Research Support Center, University of Sao Paulo, Av. dos Bandeirantes 3900, Ribeirao Preto, SP ZIP 14049-900, Brazil. Electronic address: fdmfilho@fmrp.usp.br. FAU - De Felicio, Claudia Maria AU - De Felicio CM AD - Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery, Ribeirao Preto Medical School, University of Sao Paulo, Av. dos Bandeirantes 3900, Ribeirao Preto, SP ZIP 14049-900, Brazil; Craniofacial Research Support Center, University of Sao Paulo, Av. dos Bandeirantes 3900, Ribeirao Preto, SP ZIP 14049-900, Brazil. Electronic address: cfelicio@fmrp.usp.br. FAU - Trawitzki, Luciana Vitaliano Voi AU - Trawitzki LVV AD - Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery, Ribeirao Preto Medical School, University of Sao Paulo, Av. dos Bandeirantes 3900, Ribeirao Preto, SP ZIP 14049-900, Brazil; Craniofacial Research Support Center, University of Sao Paulo, Av. dos Bandeirantes 3900, Ribeirao Preto, SP ZIP 14049-900, Brazil. Electronic address: luvoi@fmrp.usp.br. LA - eng PT - Journal Article DEP - 20241009 PL - England TA - Arch Oral Biol JT - Archives of oral biology JID - 0116711 SB - IM MH - Humans MH - Female MH - Male MH - *Orthognathic Surgical Procedures/methods MH - Longitudinal Studies MH - Adult MH - *Mastication/physiology MH - *Face/anatomy & histology MH - *Imaging, Three-Dimensional/methods MH - Bite Force MH - Malocclusion, Angle Class III/surgery/physiopathology MH - Dentofacial Deformities/surgery/physiopathology MH - Malocclusion, Angle Class II/surgery/physiopathology MH - Cephalometry MH - Treatment Outcome MH - Adolescent MH - Young Adult OTO - NOTNLM OT - Bite force OT - Dentofacial deformities OT - Mastication OT - Myofunctional therapy OT - Orthognathic surgery COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/10/20 04:18 MHDA- 2024/12/01 15:22 CRDT- 2024/10/19 18:09 PHST- 2024/05/10 00:00 [received] PHST- 2024/09/18 00:00 [revised] PHST- 2024/09/30 00:00 [accepted] PHST- 2024/12/01 15:22 [medline] PHST- 2024/10/20 04:18 [pubmed] PHST- 2024/10/19 18:09 [entrez] AID - S0003-9969(24)00224-3 [pii] AID - 10.1016/j.archoralbio.2024.106103 [doi] PST - ppublish SO - Arch Oral Biol. 2025 Jan;169:106103. doi: 10.1016/j.archoralbio.2024.106103. Epub 2024 Oct 9. PMID- 39425121 OWN - NLM STAT- MEDLINE DCOM- 20241019 LR - 20250205 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 Oct 18 TI - Association between physical activity based on wearables and self-reported health status among adolescents: NHANES 2011-2014. PG - 2876 LID - 10.1186/s12889-024-20363-6 [doi] LID - 2876 AB - BACKGROUND: Physical activity (PA) was strongly associated with health status, with fewer related studies in adolescents (12-19 years). Most current studies using questionnaires to assess PA levels were not objective enough. So, this study used a wearable device to assess PA levels quantitatively and focused on the association between PA levels and self-reported 4 health status among adolescents. METHODS: Data were obtained from adolescents (2241) with both PA and health status assessments from two cycles of NHANES, 2011-2014, using a wearable accelerometer-based device to assess PA levels quantitatively, MIMS-units as the metric, averaging over all valid days of wear (MIMS-units average). There were 4 health statuses, including (1) whether or not flu, pneumonia, or ear infection, (2) whether or not stomach or intestinal illness, (3) whether or not head cold or chest cold, and (4) general health condition, from the past 30 days self-reported. Weighted multiple logistic regression was used to analyze the association between the 4 health statuses and the MIMS-units average and MIMS-units average quartiles respectively. Subgroup analyses were also conducted on age, sex, BMI, and race. RESULTS: After controlling confounding factors, there was no significant correlation between the MIMS-units average and the four physical health conditions in Table 3 model 3. While MIMS-units average quartiles results showed that compared to lower PA levels (Q1), higher PA levels (Q4) were linked to a lower incidence of "flu"(OR = 0.94, 95% CI [0.91, 0.99], P < 0.001). Furthermore, Q3 was linked to a decrease in the incidence of "head cold" (OR = 0.91, 95% CI [0.85, 0.96], P < 0.001), while Q2 showed a decrease in "stomach illness" (OR = 0.95, 95% CI [0.92, 0.99], P = 0.003) in Table 3 model 3. Subgroup analyses showed that higher PA levels significantly reduced "flu" risk among 12-15 year-olds, girls, obese, and Non-Hispanic White; decreased "head cold" risk among 16-19 year-olds, boys, obese, and Non-Hispanic White; significantly lower risk of "stomach illness" in girls. CONCLUSIONS: Enhancing PA levels can help prevent flu, head cold, and stomach or intestinal illness in US adolescents. Further studies are needed to determine whether adolescents in other regions have similar results, and high-quality cohort studies are needed to further validate the causal association. CI - (c) 2024. The Author(s). FAU - Gao, Yan AU - Gao Y AD - Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, 100700, China. AD - ICU, Tuberculosis Department, 8th Medical Center of Chinese PLA General Hospital Tuberculosis Research Institute, Beijing, 100091, China. FAU - Zhang, Qiming AU - Zhang Q AD - Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, 100700, China. FAU - Wang, Yiguo AU - Wang Y AD - Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, 100700, China. FAU - Gao, Yu AU - Gao Y AD - Beijing Fengtai Hospital of Chinese Medicine (Beijing Fengtai Nanyuan Hospital), Beijing, 100076, China. FAU - Xu, Yang AU - Xu Y AD - TCM Clinic of China Academy of Chinese Medical Sciences, Beijing, 100700, China. 1551196656@qq.com. LA - eng GR - 2024-4-4381/Capital Health Development Research Special Project (2024-4-4381), a study on the wearable device-based objective measurement of adolescents' anxiety status in Traditional Chinese Medicine (TCM)./ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241018 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - *Self Report MH - *Exercise MH - *Health Status MH - *Wearable Electronic Devices MH - *Nutrition Surveys MH - Child MH - Accelerometry MH - United States/epidemiology MH - Young Adult PMC - PMC11490019 OTO - NOTNLM OT - Adolescents OT - NHANES OT - Physical activity OT - Self-reported health status OT - Wearables COIS- The authors declare no competing interests. EDAT- 2024/10/19 16:23 MHDA- 2024/10/19 16:24 PMCR- 2024/10/18 CRDT- 2024/10/18 23:48 PHST- 2024/04/30 00:00 [received] PHST- 2024/10/10 00:00 [accepted] PHST- 2024/10/19 16:24 [medline] PHST- 2024/10/19 16:23 [pubmed] PHST- 2024/10/18 23:48 [entrez] PHST- 2024/10/18 00:00 [pmc-release] AID - 10.1186/s12889-024-20363-6 [pii] AID - 20363 [pii] AID - 10.1186/s12889-024-20363-6 [doi] PST - epublish SO - BMC Public Health. 2024 Oct 18;24(1):2876. doi: 10.1186/s12889-024-20363-6. PMID- 39424408 OWN - NLM STAT- MEDLINE DCOM- 20241125 LR - 20260923 IS - 2044-8287 (Electronic) IS - 1359-107X (Print) IS - 1359-107X (Linking) VI - 30 IP - 1 DP - 2025 Feb TI - Self-compassion improves barrier self-efficacy and subsequently physical activity: A test of longitudinal mediation using a representative sample of the United Kingdom. PG - e12757 LID - 10.1111/bjhp.12757 [doi] LID - e12757 AB - INTRODUCTION: Self-compassion, which directs the awareness of suffering, sympathetic concerns and caring motives towards oneself, is an important psychological quality and resource for health and well-being. In the context of physical activity, self-compassion can help individuals overcome obstacles, recuperate from a setback or a lapse and engage in regular physical activity. The present research was the first to examine the longitudinal effects of self-compassion on physical activity and the mediation role of barrier self-efficacy of such effects. METHODS: We recruited a national representative sample of 654 UK adults and followed them over three timepoints across 9 months. At each time point, participants completed an online survey assessing levels of state self-compassion, barrier self-efficacy and physical activity behaviours. We examined the longitudinal effects of self-compassion on physical activity and the mediation role of barrier self-efficacy. RESULTS: Baseline state self-compassion consistently correlated with physical activity levels at Times 2 and 3. Barrier self-efficacy at Time 2 mediated the longitudinal effect of baseline state self-compassion on Time 3 physical activity, after controlling for within- (e.g., Time 1 on Time 2 self-compassion) and between-person variations (e.g., covariance of self-compassion and physical activity within a timepoint). CONCLUSIONS: Adopting a self-compassionate mind facilitates engagement and maintenance of physical activity. Future studies could consider accelerometer-based physical activity measures and develop and validate a more context-specific state self-compassion measure tailored for physical activity contexts. Researchers and practitioners should consider incorporating self-compassion to future interventions and education programmes for promoting physical activity. CI - (c) 2024 The Author(s). British Journal of Health Psychology published by John Wiley & Sons Ltd on behalf of British Psychological Society. FAU - Zhang, Shuge AU - Zhang S AUID- ORCID: 0000-0002-6935-8831 AD - Hunan University of Technology, Zhuzhou, China. AD - University of Derby, Derby, UK. FAU - Pringle, Andy AU - Pringle A AD - University of Derby, Derby, UK. FAU - Roscoe, Clare AU - Roscoe C AD - University of Derby, Derby, UK. LA - eng GR - University of Derby/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241018 PL - England TA - Br J Health Psychol JT - British journal of health psychology JID - 9605409 SB - IM MH - Humans MH - *Self Efficacy MH - United Kingdom MH - Male MH - Female MH - Adult MH - *Exercise/psychology MH - Middle Aged MH - *Empathy MH - Longitudinal Studies MH - Young Adult MH - Surveys and Questionnaires MH - Aged MH - Adolescent PMC - PMC11586801 OTO - NOTNLM OT - compassion OT - longitudinal mediation OT - panel data OT - physical activity OT - self-efficacy COIS- The authors do not have any conflict of interest. EDAT- 2024/10/19 16:23 MHDA- 2024/11/25 11:33 PMCR- 2024/11/25 CRDT- 2024/10/18 21:33 PHST- 2024/03/30 00:00 [received] PHST- 2024/09/12 00:00 [accepted] PHST- 2024/11/25 11:33 [medline] PHST- 2024/10/19 16:23 [pubmed] PHST- 2024/10/18 21:33 [entrez] PHST- 2024/11/25 00:00 [pmc-release] AID - BJHP12757 [pii] AID - 10.1111/bjhp.12757 [doi] PST - ppublish SO - Br J Health Psychol. 2025 Feb;30(1):e12757. doi: 10.1111/bjhp.12757. Epub 2024 Oct 18. PMID- 39423862 OWN - NLM STAT- MEDLINE DCOM- 20241130 LR - 20260718 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 204 DP - 2025 Jan 1 TI - Behavioral separation of liking and wanting in response to olfactory and visual food cues. PG - 107717 LID - S0195-6663(24)00521-X [pii] LID - 10.1016/j.appet.2024.107717 [doi] AB - In real-world settings, food rewards are processed in parallel across several sensory modalities, but paradigms that compare contributions of different modalities are lacking. While odor perception in particular is frequently implicated in appetite regulation, the mechanisms by which food odors differentially evoke experiences of wanting and liking remain poorly understood. This study addressed this gap by dissociating liking from wanting responses for olfactory stimuli, and establishing commonalities and differences relative to the visual modality. In two separate experiments, participants (n(1) = 37, n(2) = 43) rated content-matched batteries of odors and pictures, respectively, for their ability to elicit pleasure (liking) and desire to eat (wanting). A third experiment (n(3) = 39) utilized a combined olfactory-visual paradigm to test the separation of these dimensions in a multisensory context. Our results show that participants differentiated clearly and reliably between liking and wanting for both odors and pictures, as demonstrated by a high difference score between the two in non-food (high liking, low wanting), but not in food (both high) or disgusting stimuli (both low), and high within-session retest reliability. Higher variability for olfactory relative to visual assessments was observed and likely reflects well-established difficulties with odor object identification. Taken together, our study demonstrates that olfactory stimuli can be used in experimental settings to evoke separable experiences of liking and wanting for food and non-food stimuli. Manipulating these components independently across sensory modalities in experimental studies could generate novel insights into how olfactory and visual cues differentially contribute to anticipatory and consummatory food reward processing, in healthy and disordered eating. CI - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Savva, Androula AU - Savva A AD - Department of Clinical Neuroscience, Psychology Division, Karolinska Institutet, Stockholm, Sweden; Department of Medical Epidemiology and Biostatistics, Centre for Eating Disorders Innovation, Karolinska Institutet, Stockholm, Sweden. Electronic address: androula.savva@ki.se. FAU - Dijkman, Renee AU - Dijkman R AD - Department of Bioscience and Nutrition, Karolinska Institutet, Stockholm, Sweden. FAU - Bulik, Cynthia M AU - Bulik CM AD - Department of Medical Epidemiology and Biostatistics, Centre for Eating Disorders Innovation, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. FAU - Seubert, Janina AU - Seubert J AD - Department of Clinical Neuroscience, Psychology Division, Karolinska Institutet, Stockholm, Sweden. LA - eng PT - Journal Article DEP - 20241017 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - *Cues MH - Male MH - Adult MH - Young Adult MH - *Food Preferences/psychology MH - *Odorants MH - Olfactory Perception/physiology MH - Photic Stimulation/methods MH - Smell/physiology MH - Reward MH - Adolescent MH - Pleasure MH - Visual Perception/physiology OTO - NOTNLM OT - Appetite regulation OT - Food reward OT - Odor OT - Vision OT - Wanting COIS- Declaration of competing interest CMB receives author royalties from Pearson Education Inc. Other authors have nothing to declare and report no financial relationships with commercial interests. EDAT- 2024/10/19 16:23 MHDA- 2024/12/01 15:22 CRDT- 2024/10/18 19:12 PHST- 2024/04/30 00:00 [received] PHST- 2024/09/15 00:00 [revised] PHST- 2024/10/15 00:00 [accepted] PHST- 2024/12/01 15:22 [medline] PHST- 2024/10/19 16:23 [pubmed] PHST- 2024/10/18 19:12 [entrez] AID - S0195-6663(24)00521-X [pii] AID - 10.1016/j.appet.2024.107717 [doi] PST - ppublish SO - Appetite. 2025 Jan 1;204:107717. doi: 10.1016/j.appet.2024.107717. Epub 2024 Oct 17. PMID- 39420908 OWN - NLM STAT- MEDLINE DCOM- 20241018 LR - 20241019 IS - 2359-4292 (Electronic) IS - 2359-3997 (Print) IS - 2359-3997 (Linking) VI - 68 DP - 2024 TI - Comparison of self-assessed and clinician-assessed hirsutism diagnosed according to the modified Ferriman-Gallwey scale among female outpatients in Brazil. PG - e230271 LID - 10.20945/2359-4292-2023-0271 [doi] LID - e230271 AB - OBJECTIVE: The aim of this study was to evaluate the efficacy of a self-assessment questionnaire for hirsutism using the latest cutoff values recommended by the Endocrine Society (ES) for Latin-American women and by the European Society for Human Reproduction and Embryology (ESHRE). SUBJECT AND METHODS: Female premenopausal outpatients (n = 188) completed a self-assessment questionnaire, scoring hair presence across the nine areas evaluated by the modified Ferriman-Gallwey (mFG) scale. The results were compared with clinician-assessed scores rated independently by two trained physicians. Scores in the Hirsuta questionnaire, derived from self-assessment of five areas of the mFG scale, were also evaluated. RESULTS: The ethnic composition of the sample was as follows: 23.1% white, 25.8% black, 48.9% mixed, and 2.1% other backgrounds (Indigenous, Asian). The participants had age and BMI of (mean +/- standard deviation) 33.7 +/- 9.9 years and 29.8 +/- 7.21 kg/m(2), respectively. The most common areas of excessive hair growth were the chin, upper and lower abdomen, and thighs. Relative to clinician-assessed mFG scores, self-assessed mFG scores had an accuracy of 80% using ES criteria for hirsutism diagnosis, with a sensitivity of 95.45%, specificity of 56.25%, positive predictive value of 30.10%, and negative predictive value of 98.40%. Self-assessed mFG had lower accuracy (71%) for diagnosing hirsutism when the ESHRE criteria were applied. CONCLUSIONS: Self-assessed mFG had low specificity, limiting its application. The results of this study do not support the use of the self-assessed mFG or Hirsuta scores for diagnosing hirsutism in a clinical setting, although both scoring systems may be useful for screening hirsutism in epidemiological studies. FAU - Oliveira, Talita Fernanda AU - Oliveira TF AUID- ORCID: 0009-0007-2736-2959 AD - Departamento de Clinica Medica Faculdade de Medicina Universidade Federal de Minas Gerais Belo HorizonteMG Brasil Departamento de Clinica Medica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil. FAU - Oliveira, Talita Fischer AU - Oliveira TF AUID- ORCID: 0000-0002-4614-3109 AD - Departamento de Clinica Medica Faculdade de Medicina Universidade Federal de Minas Gerais Belo HorizonteMG Brasil Departamento de Clinica Medica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil. FAU - Santana, Dayane Campos AU - Santana DC AUID- ORCID: 0000-0002-9361-9675 AD - Departamento de Clinica Medica Faculdade de Medicina Universidade Federal de Minas Gerais Belo HorizonteMG Brasil Departamento de Clinica Medica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil. FAU - Rocha, Ana Luiza Lunardi AU - Rocha ALL AUID- ORCID: 0000-0002-4717-9541 AD - Departamento de Ginecologia Faculdade de Medicina Universidade Federal de Minas Gerais Belo HorizonteMG Brasil Departamento de Ginecologia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil. FAU - Candido, Ana Lucia AU - Candido AL AUID- ORCID: 0000-0002-9080-2319 AD - Departamento de Clinica Medica Faculdade de Medicina Universidade Federal de Minas Gerais Belo HorizonteMG Brasil Departamento de Clinica Medica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil. FAU - Comim, Fabio Vasconcellos AU - Comim FV AUID- ORCID: 0000-0002-2726-233X AD - Departamento de Clinica Medica Faculdade de Medicina Universidade Federal de Minas Gerais Belo HorizonteMG Brasil Departamento de Clinica Medica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil. AD - Faculdade de Ciencias Medicas de Minas Gerais Belo HorizonteMG Brasil Faculdade de Ciencias Medicas de Minas Gerais, Belo Horizonte, MG, Brasil. LA - eng PT - Comparative Study PT - Journal Article DEP - 20240624 PL - Brazil TA - Arch Endocrinol Metab JT - Archives of endocrinology and metabolism JID - 101652058 SB - IM MH - Humans MH - *Hirsutism/diagnosis MH - Female MH - Adult MH - Brazil MH - Surveys and Questionnaires/standards MH - Self-Assessment MH - Outpatients MH - Young Adult MH - Reproducibility of Results MH - Middle Aged MH - Diagnostic Self Evaluation MH - Adolescent MH - Sensitivity and Specificity PMC - PMC11213573 OTO - NOTNLM OT - Hirsutism OT - assessment OT - hyperandrogenism OT - polycystic ovary syndrome OT - process OT - self-assessment COIS- Disclosure: no potential conflict of interest relevant to this article was reported. EDAT- 2024/10/18 06:23 MHDA- 2024/10/18 06:24 PMCR- 2024/06/24 CRDT- 2024/10/18 04:14 PHST- 2023/07/07 00:00 [received] PHST- 2024/03/03 00:00 [accepted] PHST- 2024/10/18 06:24 [medline] PHST- 2024/10/18 06:23 [pubmed] PHST- 2024/10/18 04:14 [entrez] PHST- 2024/06/24 00:00 [pmc-release] AID - 10.20945/2359-4292-2023-0271 [doi] PST - epublish SO - Arch Endocrinol Metab. 2024 Jun 24;68:e230271. doi: 10.20945/2359-4292-2023-0271. eCollection 2024. PMID- 39416350 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241018 IS - 2477-4073 (Electronic) IS - 2528-181X (Print) IS - 2477-4073 (Linking) VI - 10 IP - 5 DP - 2024 TI - Factors influencing health literacy in overweight management among late adolescents in Thailand: A cross-sectional study. PG - 563-570 LID - 10.33546/bnj.3476 [doi] AB - BACKGROUND: Health literacy is crucial in managing health outcomes, including overweight, which is a significant issue among late adolescents. Despite the importance of health literacy in weight management, research focusing on this population remains limited. OBJECTIVE: This study aimed to investigate the factors influencing health literacy in overweight management among late adolescents in Thailand. METHODS: A cross-sectional study was conducted with late adolescents from five higher education institutions in Ubon Ratchathani Province, Thailand. A total of 403 participants were selected through multistage random sampling. Self-report questionnaires, validated for reliability and accuracy, were used to collect data from March to May 2023. Multiple regression analysis was employed, with a significance level set at 0.05. RESULTS: The sample consisted predominantly of females (91.10%) with an average age of 20-21 years (54.30%). The prevalence of overweight/obesity among participants was 25.06%. Four factors were significantly associated with health literacy in overweight management: access to health and weight control resources (r = 0.368, p <0.001), access to online social learning resources (r = 0.321, p <0.001), access to books, journals, and websites (r = 0.340, p <0.001), and management of weight control behaviors (r = 0.145, p <0.001). These factors together accounted for 20% of the variance in health literacy (R(2) = 0.200). CONCLUSION: The study identified key factors that enhance health literacy in overweight management among late adolescents in Thailand. It is recommended that nurses and other healthcare professionals develop targeted interventions focusing on these factors to effectively manage overweight in this population. CI - (c) The Author(s) 2024. FAU - Narmkul, Piyanan AU - Narmkul P AUID- ORCID: 0000-0002-9020-9742 AD - Department of Health Sciences, Faculty of Public Health, Ubon Ratchathani Rajabhat University, Ubon Ratchathani, Thailand. AD - Department of Child and Adolescent Nursing, Faculty of Nursing, Ubon Ratchathani Rajabhat University, Ubon Ratchathani, Thailand. FAU - Woradet, Somkiattiyos AU - Woradet S AUID- ORCID: 0000-0002-5758-4081 AD - Department of Public Health, Faculty of Health and Sports Science, Thaksin University, Phatthalung, Thailand. FAU - Armartpundit, Thongchai AU - Armartpundit T AUID- ORCID: 0009-0002-7858-9807 AD - Department of Community Health Nursing, Boromrajonani College of Nursing Nakhon Phanom, Nakhon Phanom University, Nakhon Phanom, Thailand. FAU - Maninet, Surachai AU - Maninet S AUID- ORCID: 0000-0002-3892-3180 AD - Faculty of Nursing, Ubon Ratchathani University, Ubon Ratchathani, Thailand. FAU - Songserm, Nopparat AU - Songserm N AUID- ORCID: 0000-0003-3741-367X AD - Department of Health Sciences, Faculty of Public Health, Ubon Ratchathani Rajabhat University, Ubon Ratchathani, Thailand. LA - eng PT - Journal Article DEP - 20241014 PL - Indonesia TA - Belitung Nurs J JT - Belitung nursing journal JID - 101685037 PMC - PMC11474267 OTO - NOTNLM OT - Thailand OT - cross-sectional study OT - health literacy OT - late adolescent OT - overweight OT - prevalence OT - regression analysis OT - young adult COIS- The authors declare no potential conflict of interest in this study. EDAT- 2024/10/17 10:05 MHDA- 2024/10/17 10:06 PMCR- 2024/10/14 CRDT- 2024/10/17 04:53 PHST- 2024/06/18 00:00 [received] PHST- 2024/07/19 00:00 [revised] PHST- 2024/09/06 00:00 [accepted] PHST- 2024/10/17 10:06 [medline] PHST- 2024/10/17 10:05 [pubmed] PHST- 2024/10/17 04:53 [entrez] PHST- 2024/10/14 00:00 [pmc-release] AID - BNJ-10-5-563 [pii] AID - 10.33546/bnj.3476 [doi] PST - epublish SO - Belitung Nurs J. 2024 Oct 14;10(5):563-570. doi: 10.33546/bnj.3476. eCollection 2024. PMID- 39415296 OWN - NLM STAT- MEDLINE DCOM- 20241017 LR - 20260712 IS - 1743-0003 (Electronic) IS - 1743-0003 (Linking) VI - 21 IP - 1 DP - 2024 Oct 17 TI - Acceptability, validity and responsiveness of inertial measurement units for assessing motor recovery after gene therapy in infants with early onset spinal muscular atrophy: a prospective cohort study. PG - 183 LID - 10.1186/s12984-024-01477-9 [doi] LID - 183 AB - BACKGROUND: Onasemnogene abeparvovec gene replacement therapy (GT) has changed the prognosis of patients with spinal muscular atrophy (SMA) with variable outcome regarding motor development in symptomatic patients. This pilot study evaluates acceptability, validity and clinical relevance of Inertial Measurement Units (IMU) to monitor spontaneous movement recovery in early onset SMA patients after GT. METHODS: Clinical assessments including CHOPINTEND score (the gold standard motor score for infants with SMA) and IMU measurements were performed before (M0) and repeatedly after GT. Inertial data was recorded during a 25-min spontaneous movement task, the child lying on the back, without (10 min) and with a playset (15 min) wearing IMUs. Two commonly used parameters, norm acceleration 95th centile (||A||_95) and counts per minute (||A||_CPM) were computed for each wrist, elbow and foot sensors. RESULTS: 23 SMA-patients were included (mean age at diagnosis 8 months [min 2, max 20], 19 SMA type 1, three type 2 and one presymptomatic) and 104 IMU-measurements were performed, all well accepted by families and 84/104 with a good child participation (evaluated with Brazelton scale). ||A||_95 and ||A||_CPM showed high internal consistency (without versus with a playset) with interclass correlation coefficient for the wrist sensors of 0.88 and 0.85 respectively and for the foot sensors of 0.93 and 0.91 respectively. ||A||_95 and ||A||_CPM were strongly correlated with CHOPINTEND (r for wrist sensors 0.74 and 0.67 respectively and for foot sensors 0.61 and 0.68 respectively, p-values < 0.001). ||A||_95 for the foot, the wrist, the elbow sensors and ||A||_CPM for the foot, the wrist, the elbow sensors increased significantly between baseline and the 12 months follow-up visit (respective p-values: 0.004, < 0.001, < 0.001, 0.006, < 0.001, < 0.001). CONCLUSION: IMUs were well accepted, consistent, concurrently valid, responsive and associated with unaided sitting acquisition especially for the elbow sensors. This study is the first reporting a large set of inertial sensor derived data after GT in SMA patients and paves the way for IMU-based follow-up of SMA patients after treatment. CI - (c) 2024. The Author(s). FAU - Barrois, R AU - Barrois R AD - Department of Pediatric Neurology, French Reference Center for Neuromuscular Diseases, AP-HP, Hopital Necker-Enfants Malades, 149 Rue de Sevres, 75015, Paris, France. remi.barrois@aphp.fr. AD - Clinical Neurophysiology Department, AP-HP, Hopital Necker Enfants Malades, Paris, France. remi.barrois@aphp.fr. AD - Universite Paris Saclay, Universite Paris Cite, ENS Paris Saclay, CNRS, SSA, INSERM, Centre Borelli, 91190, Gif-Sur-Yvette, France. remi.barrois@aphp.fr. AD - Service d'explorations Fonctionnelles, Unite de Neurophysiologie Clinique, AP-HP Hopital Necker, 149 Rue de Sevres, 75015, Paris, France. remi.barrois@aphp.fr. FAU - Tervil, B AU - Tervil B AD - Universite Paris Saclay, Universite Paris Cite, ENS Paris Saclay, CNRS, SSA, INSERM, Centre Borelli, 91190, Gif-Sur-Yvette, France. FAU - Cacioppo, M AU - Cacioppo M AD - Pediatric Neurology Unit, Children's Hospital, Geneva University Hospitals, 1205, Geneva, Switzerland. AD - LaTIM UMR 1101 Laboratory, Inserm, Brest, France. FAU - Barnerias, C AU - Barnerias C AD - Department of Pediatric Neurology, French Reference Center for Neuromuscular Diseases, AP-HP, Hopital Necker-Enfants Malades, 149 Rue de Sevres, 75015, Paris, France. FAU - Deladriere, E AU - Deladriere E AD - Department of Pediatric Neurology, French Reference Center for Neuromuscular Diseases, AP-HP, Hopital Necker-Enfants Malades, 149 Rue de Sevres, 75015, Paris, France. FAU - Leloup-Germa, V AU - Leloup-Germa V AD - Department of Pediatric Neurology, French Reference Center for Neuromuscular Diseases, AP-HP, Hopital Necker-Enfants Malades, 149 Rue de Sevres, 75015, Paris, France. FAU - Herve, A AU - Herve A AD - Department of Pediatric Neurology, French Reference Center for Neuromuscular Diseases, AP-HP, Hopital Necker-Enfants Malades, 149 Rue de Sevres, 75015, Paris, France. FAU - Oudre, L AU - Oudre L AD - Universite Paris Saclay, Universite Paris Cite, ENS Paris Saclay, CNRS, SSA, INSERM, Centre Borelli, 91190, Gif-Sur-Yvette, France. FAU - Ricard, D AU - Ricard D AD - Universite Paris Saclay, Universite Paris Cite, ENS Paris Saclay, CNRS, SSA, INSERM, Centre Borelli, 91190, Gif-Sur-Yvette, France. AD - Service de Neurologie, HIA Percy, Service de Sante des Armees, Clamart, France. FAU - Vidal, P P AU - Vidal PP AD - Universite Paris Saclay, Universite Paris Cite, ENS Paris Saclay, CNRS, SSA, INSERM, Centre Borelli, 91190, Gif-Sur-Yvette, France. FAU - Vayatis, N AU - Vayatis N AD - Universite Paris Saclay, Universite Paris Cite, ENS Paris Saclay, CNRS, SSA, INSERM, Centre Borelli, 91190, Gif-Sur-Yvette, France. FAU - Roy, S Quijano AU - Roy SQ AD - Pediatric Neurology and ICU Department, Garches Reference Center for Neuromuscular Diseases, AP-HP Paris-Saclay Universite, Hopital Raymond Poincare (UVSQ), 104 Boulevard Raymond Poincare, 92380, Garches, France. FAU - Brochard, S AU - Brochard S AD - LaTIM UMR 1101 Laboratory, Inserm, Brest, France. AD - University Hospital of Brest, Brest, France. FAU - Gitiaux, C AU - Gitiaux C AD - Department of Pediatric Neurology, French Reference Center for Neuromuscular Diseases, AP-HP, Hopital Necker-Enfants Malades, 149 Rue de Sevres, 75015, Paris, France. AD - Clinical Neurophysiology Department, AP-HP, Hopital Necker Enfants Malades, Paris, France. FAU - Desguerre, I AU - Desguerre I AD - Department of Pediatric Neurology, French Reference Center for Neuromuscular Diseases, AP-HP, Hopital Necker-Enfants Malades, 149 Rue de Sevres, 75015, Paris, France. AD - Paris Cite University, IHU Imagine, 75015, Paris, France. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241017 PL - England TA - J Neuroeng Rehabil JT - Journal of neuroengineering and rehabilitation JID - 101232233 SB - IM MH - Humans MH - Infant MH - Male MH - Female MH - Prospective Studies MH - *Genetic Therapy/methods MH - Pilot Projects MH - Muscular Atrophy, Spinal/diagnosis/physiopathology MH - Reproducibility of Results MH - Recovery of Function MH - Cohort Studies MH - Spinal Muscular Atrophies of Childhood/diagnosis/rehabilitation/therapy/physiopathology MH - Accelerometry/instrumentation PMC - PMC11483959 OTO - NOTNLM OT - Gene therapy OT - Inertial measurement unit OT - Infants OT - Neuromuscular disease OT - Quantitative movement analysis OT - Spinal muscular atrophy OT - Wearable sensors COIS- The authors declare no competing interests. EDAT- 2024/10/17 10:05 MHDA- 2024/10/17 10:06 PMCR- 2024/10/17 CRDT- 2024/10/16 23:54 PHST- 2024/03/26 00:00 [received] PHST- 2024/09/24 00:00 [accepted] PHST- 2024/10/17 10:06 [medline] PHST- 2024/10/17 10:05 [pubmed] PHST- 2024/10/16 23:54 [entrez] PHST- 2024/10/17 00:00 [pmc-release] AID - 10.1186/s12984-024-01477-9 [pii] AID - 1477 [pii] AID - 10.1186/s12984-024-01477-9 [doi] PST - epublish SO - J Neuroeng Rehabil. 2024 Oct 17;21(1):183. doi: 10.1186/s12984-024-01477-9. PMID- 39414418 OWN - NLM STAT- MEDLINE DCOM- 20241212 LR - 20260713 IS - 1879-114X (Electronic) IS - 0149-2918 (Linking) VI - 46 IP - 12 DP - 2024 Dec TI - Patient Experience With Efanesoctocog Alfa for Severe Hemophilia A: Results From the XTEND-1 Phase 3 Clinical Study Exit Interviews. PG - 1016-1023 LID - S0149-2918(24)00272-8 [pii] LID - 10.1016/j.clinthera.2024.09.010 [doi] AB - PURPOSE: Hemophilia A is a rare bleeding disorder that leads to recurrent hemarthrosis, which can ultimately result in reduced mobility and poor quality of life. Qualitative exit interviews provide insights into patient perspectives and support the interpretation of quantitative trial data, such as patient-reported outcome measures. In the Phase 3 XTEND-1 study (NCT04161495) of efanesoctocog alfa in participants with severe hemophilia A, exit interviews were conducted to understand pre- and post-study experiences with pain and physical functioning and to evaluate participants' treatment experiences. METHODS: In XTEND-1, participants (>/=12 years old) received once-weekly efanesoctocog alfa prophylaxis 50 IU/kg for 52 weeks (Arm A) or on-demand efanesoctocog alfa 50 IU/kg for 26 weeks followed by 26 weeks once-weekly prophylaxis (50 IU/kg; Arm B). Optional qualitative exit interviews were conducted using a semi-structured guide in a subset of participants following study completion. Interviews included open-ended questions about participants' pre- and post-study experiences with hemophilia A and targeted questions relating to improvements in patient-reported outcomes assessed during XTEND-1, including the Haemophilia Quality of Life Questionnaire for Adults Physical Health subscale (Haem-A-QoL PH). Content validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Intensity 3a measure was also assessed, particularly the worst pain item. FINDINGS: Exit interviews were conducted with 29 of 159 patients enrolled in XTEND-1 (mean [range] age 40 [16-73] years). Of 17 participants enrolled in Arm A, 13 (76.5%) reported a "wearing off" feeling with pre-study treatment, including more aches/pain, breakthrough bleeds, and limited physical activities. Joint pain was the most reported pre-study symptom (96.6%; n = 28/29), followed by a reduced ability to move without pain (89.7%, n = 26/29). Improvements following efanesoctocog alfa prophylaxis in >/=1 Haem-A-QoL PH domain were reported by 89.7% (n = 26/29) of participants, with improvements in joint pain, the ability to move without pain, and painful swellings reported by at least 21 (84%) participants. Participants reported that the PROMIS Pain Intensity 3a items were relevant, clear, and easy to answer. Most participants (96.6%) were "quite satisfied" or "very satisfied" with efanesoctocog alfa prophylaxis. All participants preferred efanesoctocog alfa over pre-study treatment. IMPLICATIONS: The exit interviews demonstrated that once-weekly efanesoctocog alfa prophylaxis resulted in patient-relevant and meaningful improvements in pain and physical functioning, consistent with the quantitative findings from XTEND-1. These results support the validity of the Haem-A-QoL PH and PROMIS Pain Intensity 3a assessed during XTEND-1, demonstrating the potential for change with efficacious treatment. TRIAL REGISTRY: ClinicalTrials.gov TRIAL REGISTRATION NUMBER: NCT04161495 REGISTRY URL: https://clinicaltrials.gov/study/NCT04161495. CI - Copyright (c) 2024 The Authors. Published by Elsevier Inc. All rights reserved. FAU - DiBenedetti, Dana AU - DiBenedetti D AD - RTI Health Solutions, Research Triangle Park, North Carolina. FAU - Neme, Daniela AU - Neme D AD - Hemophilia Foundation, Soler 3485, CABA, Argentina. FAU - Pan-Petesch, Brigitte AU - Pan-Petesch B AD - Hematologie Hemostase, Centre Hospitalier Regional Universitaire de Brest, Hopital A. Morvan, Brest, France. FAU - Willemze, Annemieke AU - Willemze A AD - Sanofi, Paasheuvelweg 25, 1105, Amsterdam, The Netherlands. Electronic address: annemieke.willemze@sanofi.com. FAU - Wynn, Tung AU - Wynn T AD - Division of Hematology & Oncology, Department of Pediatrics, University of Florida, Gainesville, Florida. FAU - Kragh, Nana AU - Kragh N AD - Sobi, SE-112 76 Stockholm, Sweden. FAU - Wilson, Amanda AU - Wilson A AD - Sanofi, 270 Albany Street, Cambridge, 02139, Massachusetts. LA - eng SI - ClinicalTrials.gov/NCT04161495 PT - Clinical Trial, Phase III PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20241015 PL - United States TA - Clin Ther JT - Clinical therapeutics JID - 7706726 RN - 9001-27-8 (Factor VIII) SB - IM MH - Humans MH - *Hemophilia A/drug therapy MH - Adult MH - *Quality of Life MH - Male MH - *Patient Reported Outcome Measures MH - Adolescent MH - Middle Aged MH - Young Adult MH - Factor VIII/administration & dosage/therapeutic use MH - Treatment Outcome MH - Interviews as Topic MH - Hemarthrosis/prevention & control MH - Severity of Illness Index MH - Female OTO - NOTNLM OT - Exit interviews OT - Health outcomes research OT - Hemophilia OT - Patient-reported outcomes OT - Prophylaxis COIS- Declaration of competing interest Dana DiBenedetti is a full-time employee of RTI Health Solutions, an independent non-profit research organization, which was retained by Sanofi to conduct the research which is the subject of this manuscript. Her compensation is unconnected to the studies on which she works. Daniela Neme has received personal or institutional honoraria from Biomarin, CSL Behring, Novo Nordisk, Pfizer, Roche, Sanofi, and Takeda. Brigitte Pan-Petesch has no conflicts of interest to declare. Annemieke Willemze is an employee of Sanofi and may hold stock or stock options in Sanofi. Tung Wynn has participated as a study PI for Sanofi, Takeda, Spark, and Sobi. Spouse was an employee of Takeda from October 2022 until June 2023. Nana Kragh is an employee of Sobi and may have stock or stock options. Amanda Wilson was an employee of Sanofi at the time the study was conducted and may hold stock or stock options in Sanofi. EDAT- 2024/10/17 10:03 MHDA- 2024/12/13 00:23 CRDT- 2024/10/16 21:53 PHST- 2024/04/08 00:00 [received] PHST- 2024/08/12 00:00 [revised] PHST- 2024/09/08 00:00 [accepted] PHST- 2024/12/13 00:23 [medline] PHST- 2024/10/17 10:03 [pubmed] PHST- 2024/10/16 21:53 [entrez] AID - S0149-2918(24)00272-8 [pii] AID - 10.1016/j.clinthera.2024.09.010 [doi] PST - ppublish SO - Clin Ther. 2024 Dec;46(12):1016-1023. doi: 10.1016/j.clinthera.2024.09.010. Epub 2024 Oct 15. PMID- 39412804 OWN - NLM STAT- MEDLINE DCOM- 20241016 LR - 20250721 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 7 IP - 10 DP - 2024 Oct 1 TI - Patient-Reported Outcomes Among Adults With Congenital Heart Disease in the Congenital Heart Initiative Registry. PG - e2439629 LID - 10.1001/jamanetworkopen.2024.39629 [doi] LID - e2439629 AB - IMPORTANCE: In the US, there are more than 1.5 million adults living with congenital heart disease (CHD). The Congenital Heart Initiative (CHI) is a digital, online, patient-empowered registry that was created to advance multicenter research and improve clinical care by gathering patient-reported outcomes (PROs) in adults with CHD. OBJECTIVE: To report the initial findings of the PROs for adults with CHD from the first 3 years of the CHI. DESIGN, SETTING, AND PARTICIPANTS: The CHI was launched nationally on December 7, 2020, as an observational cohort (survey) study. Data were collected virtually through December 31, 2023, and stored on Health Insurance Portability and Accountability Act-compliant cloud-based servers with restricted access. Adults with CHD were recruited through email, social media, general advertising through advocacy organizations, and targeted outreach (telephone and in-clinic recruitment) by clinical centers. MAIN OUTCOMES AND MEASURES: Demographics and validated survey tools on quality of life, mental health, physical activity, and health care utilization were collected at baseline and every 4 months. Descriptive statistics were used to understand the associations between various factors, including the complexity of heart defects, physical activity levels, mental health comorbidities, and socioeconomic and health care access variables. All categorical variables were analyzed using chi2 or Fischer exact test as appropriate. RESULTS: By December 31, 2023, the CHI had enrolled 4558 participants (2530 female [56%]) with a mean (SD) age of 38.5 (13.9) years, representing all 50 states. Approximately 88% of participants (3998 participants) completed at least 1 electronic visit as of December 31, 2023. The most prevalent CHD anatomy included tetralogy of Fallot (883 participants [22%]), transposition of great arteries (452 participants [11%]), and coarctation of the aorta (429 participants [11%]). Approximately 88% of participants (3998 participants) reported at least 1 comorbidity, with arrhythmia (1300 participants [33%]) as the most common cardiac comorbidity and mood disorder (1326 participants [35%]) as the most common noncardiac comorbidity. Among female participants, 45% (1147 participants) reported having had a pregnancy, with 38% (967 participants) resulting in biological children. Participants with complex CHD were less likely than those with moderate CHD to meet recommended physical activity guidelines (chi22 = 15.9; n = 3320; P < .001), a factor that was more pronounced among female participants. Overall health-related quality of life was rated as good or better by 84% of participants who completed the quality of life PROs (2882 participants), with no difference by CHD complexity. CONCLUSIONS AND RELEVANCE: In this cohort study of adults living with CHD, many patients reported mood disorders, but most reported good health-related quality of life. The CHI, the largest registry of adults with CHD, is poised to facilitate multicenter research with the goal of improving clinical outcomes for all adults with CHD. FAU - Leezer, Scott AU - Leezer S AD - CURA Strategies, Arlington, Virginia. FAU - Mehta, Rittal AU - Mehta R AD - Division of Pediatric Cardiology, Children's National Hospital, Washington, DC. FAU - Agarwal, Anushree AU - Agarwal A AD - Division of Cardiology, University of California San Francisco, San Francisco. FAU - Saraf, Sneha AU - Saraf S AD - Division of Pediatric Cardiology, Children's National Hospital, Washington, DC. FAU - Messmer, Mindi AU - Messmer M AD - Division of Pediatric Cardiology, Children's National Hospital, Washington, DC. FAU - Phillippi, Ruth AU - Phillippi R AD - Division of Pediatric Cardiology, Children's National Hospital, Washington, DC. FAU - Jackson, Jamie L AU - Jackson JL AD - Center for Behavioral Health, Nationwide Children's Hospital, Columbus, Ohio. FAU - Roeder, Mark AU - Roeder M AD - Adult Congenital Heart Association, Philadelphia, Pennsylvania. FAU - Marlin, Aliza AU - Marlin A AD - Adult Congenital Heart Association, Philadelphia, Pennsylvania. FAU - Peyser, Noah D AU - Peyser ND AD - Division of Cardiology, University of California San Francisco, San Francisco. FAU - Pletcher, Mark J AU - Pletcher MJ AD - Division of Cardiology, University of California San Francisco, San Francisco. FAU - Krasuski, Richard AU - Krasuski R AD - Division of Cardiology, Duke University Health System, Durham, North Carolina. FAU - Lewis, Matthew AU - Lewis M AD - Division of Cardiology, Columbia University Irving Medical Center, New York, New York. FAU - Reardon, Leigh AU - Reardon L AD - Division of Pediatric Cardiology, University of California Los Angeles, Los Angeles. FAU - Saidi, Arwa AU - Saidi A AD - Congenital Heart Center, University of Florida, Gainesville. FAU - Kanter, Ronald AU - Kanter R AD - Division of Pediatric Cardiology, Nicklaus Children's Hospital, Miami, Florida. FAU - Sandhu, Satinder AU - Sandhu S AD - Division of Pediatric Cardiology, University of Miami, Miami, Florida. FAU - Young, Thomas AU - Young T AD - Division of Pediatric Cardiology, Ochsner Health, New Orleans, Louisiana. FAU - Jacobsen, Roni AU - Jacobsen R AD - Division of Pediatric Cardiology, Children's Hospital of Colorado, Denver. FAU - Ruckdeschel, Emily AU - Ruckdeschel E AD - Division of Pediatric Cardiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. FAU - Lubert, Adam AU - Lubert A AD - Division of Pediatric Cardiology, Cincinnati Children's Hospital, Cincinnati, Ohio. FAU - Singh, Simran AU - Singh S AD - Division of Cardiology, Weill Cornell Medicine, New York, New York. FAU - Zaidi, Ali AU - Zaidi A AD - Division of Cardiology, Mt. Sinai Hospital, New York, New York. FAU - Halpern, Dan H AU - Halpern DH AD - Division of Cardiology, NYU Langone Health, New York, New York. FAU - Mathews, Anita AU - Mathews A AD - Division of Pediatric Cardiology, Children's National Hospital, Washington, DC. FAU - Carton, Thomas AU - Carton T AD - Louisiana Public Health Institute, New Orleans. FAU - John, Anitha S AU - John AS AD - Division of Pediatric Cardiology, Children's National Hospital, Washington, DC. LA - eng GR - K23 HL151866/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20241001 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Humans MH - *Heart Defects, Congenital/psychology MH - Female MH - Male MH - Adult MH - *Patient Reported Outcome Measures MH - *Registries MH - *Quality of Life MH - Middle Aged MH - United States/epidemiology MH - Exercise MH - Cohort Studies MH - Mental Health/statistics & numerical data PMC - PMC11581669 COIS- Conflict of Interest Disclosures: Dr Krasuski reported receiving personal fees from Actelion/Janssen, Bayer, Gore Medical, Medtronic, and Neptune; and grants from Actelion/Janssen and the Adult Congenital Heart Association outside the submitted work. Dr Halpern reported receiving personal fees from Medtronic outside the submitted work. No other disclosures were reported. EDAT- 2024/10/16 12:24 MHDA- 2024/10/16 12:25 PMCR- 2024/10/16 CRDT- 2024/10/16 11:34 PHST- 2024/10/16 12:25 [medline] PHST- 2024/10/16 12:24 [pubmed] PHST- 2024/10/16 11:34 [entrez] PHST- 2024/10/16 00:00 [pmc-release] AID - 2824913 [pii] AID - zoi241142 [pii] AID - 10.1001/jamanetworkopen.2024.39629 [doi] PST - epublish SO - JAMA Netw Open. 2024 Oct 1;7(10):e2439629. doi: 10.1001/jamanetworkopen.2024.39629. PMID- 39411887 OWN - NLM STAT- MEDLINE DCOM- 20241016 LR - 20260531 IS - 1096-9071 (Electronic) IS - 0146-6615 (Linking) VI - 96 IP - 10 DP - 2024 Oct TI - Kaposi's sarcoma-associated herpesvirus infection and its association with all-cause and cardiovascular mortality in the general adults: A prospective cohort study. PG - e29953 LID - 10.1002/jmv.29953 [doi] AB - To investigate the association between Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 (HHV8) infection and both all-cause and cardiovascular mortality in a representative cohort of US adults, data from the National Health and Nutrition Examination Survey III (NHANES III; 1988‒1994) were analyzed, including 13,993 participants aged 18‒90 years who underwent KSHV serology evaluations. Mortality outcomes were ascertained through December 2019 using the National Death Index. Cox proportional hazards models were employed to examine the association between KSHV seropositivity and mortality, adjusting for potential confounders such as age, sex, ethnicity, body mass index, and serum TG. Over a median follow-up period of 26.5 years, 5503 deaths were recorded. KSHV seropositivity was associated with an increased hazard of all-cause mortality (Hazard Ratio [HR]: 1.32, 95% Confidence Interval [CI]: 1.03‒1.69) and cardiovascular mortality (HR: 1.58, 95% CI: 1.00‒2.50) after adjusting for age, sex, ethnicity, and body mass index. Notably, the association between KSHV infection and all-cause mortality persisted among women (HR: 1.32, 95% CI: 1.02‒1.72) after adjusting for all confounders, whereas the association with cardiovascular mortality was only statistically significant for men (HR: 1.90, 95% CI: 1.02, 3.53).KSHV infection may represent an independent risk factor for all-cause and cardiovascular mortality among US adults. These findings highlight the need for further research to validate these associations in independent populations and to elucidate the biological mechanisms underlying the observed increased mortality associated with KSHV infection. CI - (c) 2024 Wiley Periodicals LLC. FAU - Huang, Xiaoping AU - Huang X AD - Longgang Central Hospital, Shenzhen, China. AD - Department of Epidemiology, School of Public Health (Shenzhen), Sun Yat-Sen University, China. FAU - Huang, Xueliang AU - Huang X AD - Longgang Central Hospital, Shenzhen, China. FAU - Li, Yushao AU - Li Y AD - Longgang Central Hospital, Shenzhen, China. FAU - Li, Lixia AU - Li L AD - Longgang Central Hospital, Shenzhen, China. FAU - Liao, Jiaman AU - Liao J AD - Longgang Central Hospital, Shenzhen, China. FAU - Huang, Hao AU - Huang H AD - Longgang Central Hospital, Shenzhen, China. FAU - Zhao, Ying AU - Zhao Y AD - Longgang Central Hospital, Shenzhen, China. FAU - Zhan, Yiqiang AU - Zhan Y AUID- ORCID: 0000-0001-5815-9725 AD - Department of Epidemiology, School of Public Health (Shenzhen), Sun Yat-Sen University, China. LA - eng PT - Journal Article PL - United States TA - J Med Virol JT - Journal of medical virology JID - 7705876 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Middle Aged MH - *Herpesvirus 8, Human MH - *Cardiovascular Diseases/mortality MH - Prospective Studies MH - Aged MH - Young Adult MH - *Herpesviridae Infections/mortality/complications/epidemiology/virology MH - United States/epidemiology MH - Adolescent MH - *Nutrition Surveys MH - Aged, 80 and over MH - Risk Factors MH - Proportional Hazards Models MH - Sarcoma, Kaposi/mortality/virology MH - Cause of Death OTO - NOTNLM OT - Human herpesvirus 8 OT - Kaposi's sarcoma-associated herpesvirus OT - NHANES OT - cohort study OT - mortality EDAT- 2024/10/16 06:22 MHDA- 2024/10/16 06:23 CRDT- 2024/10/16 05:33 PHST- 2024/09/21 00:00 [revised] PHST- 2024/07/20 00:00 [received] PHST- 2024/09/25 00:00 [accepted] PHST- 2024/10/16 06:23 [medline] PHST- 2024/10/16 06:22 [pubmed] PHST- 2024/10/16 05:33 [entrez] AID - 10.1002/jmv.29953 [doi] PST - ppublish SO - J Med Virol. 2024 Oct;96(10):e29953. doi: 10.1002/jmv.29953. PMID- 39409234 OWN - NLM STAT- MEDLINE DCOM- 20241016 LR - 20241019 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 24 IP - 19 DP - 2024 Sep 25 TI - Agreement and Sensitivity of the Acceleration-Velocity Profile Derived via Local Positioning System. LID - 10.3390/s24196192 [doi] LID - 6192 AB - Sprint performance is commonly assessed via discrete sprint tests and analyzed through kinematic estimates modeled using a mono-exponential equation, including estimated maximal sprinting speed (MSS), relative acceleration (TAU), maximum acceleration (MAC), and relative propulsive maximal power (PMAX). The acceleration-velocity profile (AVP) provides a simple summary of short sprint performance using two parameters: MSS and MAC, which are useful for simplifying descriptions of sprint performance, comparison between athletes and groups of athletes, and estimating changes in performance over time or due to training intervention. However, discrete testing poses logistical challenges and defines an athlete's AVP exclusively from the performance achieved in an isolated testing environment. Recently, an in situ AVP (velocity-acceleration method) was proposed to estimate kinematic parameters from velocity and acceleration data obtained via global or local positioning systems (GPS/LPS) over multiple training sessions, plausibly improving the time efficiency of sprint monitoring and increasing the sample size that defines the athlete's AVP. However, the validity and sensitivity of estimates derived from the velocity-acceleration method in relation to changes in criterion scores remain elusive. To assess the concurrent validity and sensitivity of kinematic measures from the velocity-acceleration method, 31 elite youth basketball athletes (23 males and 8 females) completed two maximal effort 30 m sprint trials. Performance was simultaneously measured by a laser gun and an LPS (Kinexon), with kinematic parameters estimated using the time-velocity and velocity-acceleration methods. Agreement (%Bias) between laser gun and LPS-derived estimates was within the practically significant magnitude (+/-5%), while confidence intervals for the percentage mean absolute difference (%MAD) overlapped practical significance for TAU, MAC, and PMAX using the velocity-acceleration method. Only the MSS parameter showed a sensitivity (%MDC95) within practical significance (<5%), with all other parameters showing unsatisfactory sensitivity (>10%) for both the time-velocity and velocity-acceleration methods. Thus, sports practitioners may be confident in the concurrent validity and sensitivity of MSS estimates derived in situ using the velocity-acceleration method, while caution should be applied when using this method to infer an athlete's maximal acceleration capabilities. FAU - Jovanovic, Mladen AU - Jovanovic M AUID- ORCID: 0000-0002-4013-6530 AD - Faculty of Sport and Physical Education, University of Belgrade, 11000 Belgrade, Serbia. FAU - Arguedas-Soley, Adriano AU - Arguedas-Soley A AD - School of Health Sciences, Western Sydney University, Sydney, NSW 2751, Australia. AD - High Performance Department, Greater Western Sydney Giants Football Club, Sydney, NSW 2751, Australia. FAU - Cabarkapa, Dimitrije AU - Cabarkapa D AUID- ORCID: 0000-0001-9912-3251 AD - Jayhawk Athletic Performance Laboratory-Wu Tsai Human Performance Alliance, Department of Health, Sport and Exercise Sciences, University of Kansas, Lawrence, KS 66045, USA. FAU - Andersson, Hakan AU - Andersson H AD - High Performance Center, 35246 Vaxjo, Sweden. FAU - Nagy, Dora AU - Nagy D AD - Faculty of Health Sciences, Doctoral School of Health Sciences, University of Pecs, 7621 Pecs, Hungary. AD - Faculty of Health Sciences, Institute of Physiotherapy and Sport Science, University of Pecs, 7621 Pecs, Hungary. FAU - Trunic, Nenad AU - Trunic N AUID- ORCID: 0000-0001-5339-7695 AD - Faculty of Physical Culture and Sports Management, Singidunum University, 11000 Belgrade, Serbia. FAU - Bankovic, Vladimir AU - Bankovic V AUID- ORCID: 0009-0000-5133-4383 AD - Faculty of Physical Culture and Sports Management, Singidunum University, 11000 Belgrade, Serbia. FAU - Richard, Repasi AU - Richard R AD - Center for Basketball Methodology and Education, 7621 Pecs, Hungary. FAU - Safar, Sandor AU - Safar S AUID- ORCID: 0009-0006-2016-4434 AD - Institute of Sport, Training Theory and Methodology Research Center, University of Physical Education, 1123 Budapest, Hungary. FAU - Ratgeber, Laszlo AU - Ratgeber L AD - Faculty of Health Sciences, Institute of Physiotherapy and Sport Science, University of Pecs, 7621 Pecs, Hungary. AD - Center for Basketball Methodology and Education, 7621 Pecs, Hungary. AD - Department of Sports Games, Institute of Sport, University of Physical Education, 1123 Budapest, Hungary. LA - eng PT - Journal Article DEP - 20240925 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - *Acceleration MH - Male MH - Female MH - *Running/physiology MH - Biomechanical Phenomena/physiology MH - *Geographic Information Systems MH - Adolescent MH - *Athletes MH - *Athletic Performance/physiology PMC - PMC11478346 OTO - NOTNLM OT - GPS OT - LPS OT - athlete OT - in situ OT - performance OT - speed OT - sport OT - sprinting OT - testing COIS- The authors declare no conflicts of interest. EDAT- 2024/10/16 10:18 MHDA- 2024/10/16 10:19 PMCR- 2024/09/25 CRDT- 2024/10/16 01:11 PHST- 2024/07/18 00:00 [received] PHST- 2024/09/02 00:00 [revised] PHST- 2024/09/20 00:00 [accepted] PHST- 2024/10/16 10:19 [medline] PHST- 2024/10/16 10:18 [pubmed] PHST- 2024/10/16 01:11 [entrez] PHST- 2024/09/25 00:00 [pmc-release] AID - s24196192 [pii] AID - sensors-24-06192 [pii] AID - 10.3390/s24196192 [doi] PST - epublish SO - Sensors (Basel). 2024 Sep 25;24(19):6192. doi: 10.3390/s24196192. PMID- 39408219 OWN - NLM STAT- MEDLINE DCOM- 20241016 LR - 20241019 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 19 DP - 2024 Sep 26 TI - Psychometric Properties of the Preference for Intuition and Deliberation in Eating Decision-Making Scale among Brazilian Adult Women. LID - 10.3390/nu16193252 [doi] LID - 3252 AB - The Preference for Intuition and Deliberation in Food Decision-Making Scale (E-PID) was developed to evaluate both intuitive and deliberative food decision-making within a single instrument. However, its psychometric properties have only been assessed among German-speaking participants. The main aim of the present study was to evaluate evidence of validity and reliability of the E-PID among 604 Brazilian adult women. Exploratory (n = 289) and confirmatory factor analyses (n = 315) were conducted to evaluate the factor structure of the E-PID. Convergent validity was assessed correlating the E-PID with measures of eating behaviors (Tree-Factor Eating Questionnaire-18), intuitive eating (Intuitive Eating Scale-2), and a measure of beliefs and attitudes towards food (Food-Life Questionnaire-SF). McDonald's Omega coefficient (omega) was used to test the internal consistency of the E-PID. Results from an exploratory and confirmatory factor analysis supported a two-factor structure with seven items. We found good internal consistency (McDonald's omega = 0.77-0.81). Furthermore, the E-PID demonstrated adequate convergent validity with measures of intuitive, restrictive, emotional and uncontrolled eating, and beliefs and attitudes towards food. Results support the use of the E-PID as a measure of intuition and deliberation in food decision-making among Brazilian adult women, expanding the literature on eating decision-making styles. FAU - Resende, Thaina Richelli Oliveira AU - Resende TRO AUID- ORCID: 0000-0003-4896-5605 AD - Body Image and Eating Disorders Research Group (NICTA), Federal University of Juiz de Fora, Governador Valadares 35010-180, MG, Brazil. FAU - de Sousa, Edilene Marcia AU - de Sousa EM AUID- ORCID: 0009-0009-3820-1303 AD - Body Image and Eating Disorders Research Group (NICTA), Federal University of Juiz de Fora, Governador Valadares 35010-180, MG, Brazil. AD - Postgraduate Program in Applied Health Sciences (PPgCAS), Federal University of Juiz de Fora, Governador Valadares 35010-180, MG, Brazil. FAU - Alvarenga, Marle Dos Santos AU - Alvarenga MDS AUID- ORCID: 0000-0001-6922-2670 AD - Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo 01246-904, SP, Brazil. FAU - Ferreira, Mariana Cristina Palermo AU - Ferreira MCP AD - Body Image and Eating Disorders Research Group (NICTA), Federal University of Juiz de Fora, Governador Valadares 35010-180, MG, Brazil. FAU - Povoa, Larissa Stefhanne Damasceno de Amorim AU - Povoa LSDA AD - Postgraduate Program in Applied Health Sciences (PPgCAS), Federal University of Juiz de Fora, Governador Valadares 35010-180, MG, Brazil. FAU - Galvane, Leandro Henrique Pereira AU - Galvane LHP AD - Postgraduate Program in Applied Health Sciences (PPgCAS), Federal University of Juiz de Fora, Governador Valadares 35010-180, MG, Brazil. FAU - Lemos, Cleidiel Aparecido Araujo AU - Lemos CAA AD - Department of Dentistry, Federal University of Juiz de Fora, Governador Valadares 35010-180, MG, Brazil. FAU - Raposo, Antonio AU - Raposo A AUID- ORCID: 0000-0002-5286-2249 AD - CBIOS (Research Center for Biosciences and Health Technologies), Universidade Lusofona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisboa, Portugal. FAU - Saraiva, Ariana AU - Saraiva A AD - Department of Animal Pathology and Production, Bromatology and Food Technology, Faculty of Veterinary, Universidad de Las Palmas de Gran Canaria, Trasmontana s/n, 35413 Arucas, Spain. FAU - Carrascosa, Conrado AU - Carrascosa C AUID- ORCID: 0000-0003-2802-7873 AD - Department of Animal Pathology and Production, Bromatology and Food Technology, Faculty of Veterinary, Universidad de Las Palmas de Gran Canaria, Trasmontana s/n, 35413 Arucas, Spain. FAU - Alturki, Hmidan A AU - Alturki HA AUID- ORCID: 0000-0003-4359-063X AD - King Abdulaziz City for Science & Technology, Wellness and Preventive Medicine Institute-Health Sector, Riyadh 11442, Saudi Arabia. FAU - de Carvalho, Pedro Henrique Berbert AU - de Carvalho PHB AUID- ORCID: 0000-0002-4918-5080 AD - Body Image and Eating Disorders Research Group (NICTA), Federal University of Juiz de Fora, Governador Valadares 35010-180, MG, Brazil. AD - Eating Disorders Program, Institute of Psychiatry (AMBULIM), University of Sao Paulo, Sao Paulo 05403-010, SP, Brazil. LA - eng GR - CAPES; Finance Code 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ PT - Journal Article DEP - 20240926 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Adult MH - *Psychometrics MH - Brazil MH - *Intuition MH - *Decision Making MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - Young Adult MH - *Food Preferences/psychology MH - *Feeding Behavior/psychology MH - Middle Aged MH - Factor Analysis, Statistical MH - Adolescent MH - Eating/psychology PMC - PMC11478558 OTO - NOTNLM OT - cross-cultural adaptation OT - decision-making OT - feeding behaviors OT - intuitive eating OT - measurement OT - psychometrics OT - reliability OT - validity COIS- The authors declare no conflicts of interest. EDAT- 2024/10/16 06:22 MHDA- 2024/10/16 06:23 PMCR- 2024/09/26 CRDT- 2024/10/16 01:05 PHST- 2024/08/14 00:00 [received] PHST- 2024/09/17 00:00 [revised] PHST- 2024/09/24 00:00 [accepted] PHST- 2024/10/16 06:23 [medline] PHST- 2024/10/16 06:22 [pubmed] PHST- 2024/10/16 01:05 [entrez] PHST- 2024/09/26 00:00 [pmc-release] AID - nu16193252 [pii] AID - nutrients-16-03252 [pii] AID - 10.3390/nu16193252 [doi] PST - epublish SO - Nutrients. 2024 Sep 26;16(19):3252. doi: 10.3390/nu16193252. PMID- 39406057 OWN - NLM STAT- MEDLINE DCOM- 20241207 LR - 20260812 IS - 1873-7757 (Electronic) IS - 0145-2134 (Linking) VI - 158 DP - 2024 Dec TI - Deprivation-related adverse childhood experiences and cognitive function among older adults: Mediating role of depression symptoms. PG - 107088 LID - S0145-2134(24)00478-2 [pii] LID - 10.1016/j.chiabu.2024.107088 [doi] AB - BACKGROUND: Cognitive dysfunction imposes a heavy economic burden on families and society. Depression and deprivation-related adverse childhood experiences (ACEs) are important factors that contribute to cognitive dysfunction. However, few studies have explored these complex interactions. OBJECTIVE: This study aimed to elucidate the mediating effect of depression on the relationship between deprivation-related ACEs and cognitive function in older adults. METHODS: This national, cross-sectional study used data from the 2020 Chinese Longitudinal Aging Social Survey. Information regarding depression, ACEs, and cognitive function was collected from individuals aged 60 years and older. A structural equation model was used to examine the mediating effect of depression on the relationship between deprivation-related ACEs and cognitive function. RESULTS: A total of 9828 participants were included in this study. Their mean total cognitive function score was 13.488 +/- 3.006. The results showed that sex, age, educational level, marital status, body mass index, registered residence, chronic disease situation, health, smoking, living alone, life satisfaction, social security, and internet use were all related to cognitive function (P < 0.05). Deprivation-related ACEs were negatively correlated with cognitive function (r = -0.132, P < 0.01). And depression symptoms were negatively correlated with cognitive function (r = -0.158, P < 0.01). The mediating effect analysis indicated that depression symptoms had a significant mediating effect between the 3 dimensions of deprivation-related ACEs and cognitive function. CONCLUSIONS: This study highlighted that improvement of deprivation-related ACEs was indirectly related to a reduced likelihood of cognitive dysfunction through depression in older adults. With the limitations of cross-sectional studies, validation through longitudinal design studies is deemed necessary. Future interventions should focus on alleviating depression symptoms to prevent cognitive decline and impairment in this population. CI - Copyright (c) 2024 Elsevier Ltd. All rights reserved. FAU - Zhang, Na AU - Zhang N AD - School of Nursing, Health Science Center, Xian Jiaotong University, Xi'an, China. FAU - Yao, Yisong AU - Yao Y AD - The Fourth Clinical Medical College, Qingdao University, Yantai, China. FAU - Li, Limin AU - Li L AD - Sichuan Primary Health Care Development Research Centre, North Sichuan Medical College, Nanchong 637000, China. FAU - Sun, Mingjun AU - Sun M AD - Sichuan Primary Health Care Development Research Centre, North Sichuan Medical College, Nanchong 637000, China. FAU - Zhou, Baihe AU - Zhou B AD - School of Nursing, Health Science Center, Xian Jiaotong University, Xi'an, China. FAU - Fu, Hong AU - Fu H AD - School of Nursing, Health Science Center, Xian Jiaotong University, Xi'an, China. FAU - Guo, Binjin AU - Guo B AD - School of Nursing, Health Science Center, Xian Jiaotong University, Xi'an, China. FAU - Li, Qing AU - Li Q AD - School of Nursing, Health Science Center, Xian Jiaotong University, Xi'an, China. FAU - Jinfu, Wang AU - Jinfu W AD - School of Physical Education, South China University of Technology, Guangzhou, China. FAU - Jiang, Wenhui AU - Jiang W AD - School of Nursing, Health Science Center, Xian Jiaotong University, Xi'an, China. Electronic address: jiangwenhui@mail.xjtu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241015 PL - England TA - Child Abuse Negl JT - Child abuse & neglect JID - 7801702 SB - IM MH - Humans MH - Male MH - Female MH - *Adverse Childhood Experiences/statistics & numerical data MH - Aged MH - Cross-Sectional Studies MH - Middle Aged MH - *Depression/epidemiology/psychology MH - *Cognition MH - *Cognitive Dysfunction/epidemiology/etiology/psychology MH - China/epidemiology MH - Aged, 80 and over MH - Longitudinal Studies OTO - NOTNLM OT - China OT - Cognitive function OT - Cross-sectional OT - Depression symptoms OT - Deprivation-related adverse childhood experiences OT - Structural equation model COIS- Declaration of competing interest The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2024/10/16 00:23 MHDA- 2024/12/08 01:11 CRDT- 2024/10/15 18:11 PHST- 2024/06/02 00:00 [received] PHST- 2024/09/20 00:00 [revised] PHST- 2024/10/04 00:00 [accepted] PHST- 2024/12/08 01:11 [medline] PHST- 2024/10/16 00:23 [pubmed] PHST- 2024/10/15 18:11 [entrez] AID - S0145-2134(24)00478-2 [pii] AID - 10.1016/j.chiabu.2024.107088 [doi] PST - ppublish SO - Child Abuse Negl. 2024 Dec;158:107088. doi: 10.1016/j.chiabu.2024.107088. Epub 2024 Oct 15. PMID- 39402555 OWN - NLM STAT- MEDLINE DCOM- 20241015 LR - 20250205 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 Oct 14 TI - Reliability assessment of the 'field audit for children's active transport routes to school' (FACTS) tool. PG - 2812 LID - 10.1186/s12889-024-20285-3 [doi] LID - 2812 AB - BACKGROUND: Children's active travel to school is associated with physical activity and thus health. Safe Routes to School (SR2S) programs identify 'safe routes' to promote children's active travel to school. No field audit tool exists specifically to assess the microscale built environment of these 'safe routes' within Australia. This study describes the reliability assessment of the Field Audit for Children's Active Transport to School (FACTS) tool. METHODS: The FACTS tool was developed using a multi-step process, including a literature search, expert opinion, and pilot testing. For the reliability assessment, two trained auditors collected data at eight schools over three weeks in April 2021. For inter-rater reliability, auditors conducted audits on the 'safe routes' for the same six schools. For intra-rater reliability, auditors conducted repeat measures on the 'safe routes' for four schools each (eight schools total), including three different schools each from the six used for inter-rater reliability and one additional school. Item-by-item reliability was assessed using Cohen's Kappa, Cohen's Weighted Kappa, and percentage agreement. The reliability of calculated domain scores was assessed using intraclass correlation coefficients. RESULTS: For inter-rater reliability, 31 of the 45 (68.9%) items had moderate to almost perfect agreement, seven items (15.6%) had below moderate agreement, and a Kappa statistic could not be calculated for seven items (15.6%) due to constant values. For intra-rater reliability, 37 of the 45 (82.2%) items had moderate to almost perfect agreement, two items (4.4%) had below moderate agreement, and a Kappa statistic could not be calculated for six items (13.3%) due to constant values. For inter- and intra-rater reliability of the segment domain scores, three of the four domains had substantial to almost perfect agreement. For inter- and intra-rater reliability of the crossing domain scores, all four domains had moderate to almost perfect agreement. For inter- and intra-rater reliability of the segment, crossing, route, and school scores, all had substantial to perfect agreement. CONCLUSIONS: The FACTS tool can reliably characterise the microscale built environment of promoted 'safe routes' for their use within SR2S programs, and should be considered for use in future SR2S programs within the suburban Australian context. CI - (c) 2024. The Author(s). FAU - Vasey, Thomas V AU - Vasey TV AD - Health Research Institute, University of Canberra, Canberra, ACT, Australia. thomas.vasey@canberra.edu.au. FAU - Dale, Michael J AU - Dale MJ AD - Health Research Institute, University of Canberra, Canberra, ACT, Australia. FAU - Carroll, Suzanne J AU - Carroll SJ AD - Health Research Institute, University of Canberra, Canberra, ACT, Australia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241014 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - *Schools MH - Child MH - Reproducibility of Results MH - Australia MH - *Transportation MH - Exercise PMC - PMC11472530 OTO - NOTNLM OT - Active school transport OT - Active school transportation OT - Active school travel OT - Built environment OT - Children OT - Evaluation OT - Microscale audit tool OT - Safe routes to school COIS- The authors declare no competing interests. EDAT- 2024/10/15 00:20 MHDA- 2024/10/15 07:19 PMCR- 2024/10/14 CRDT- 2024/10/14 23:47 PHST- 2024/04/14 00:00 [received] PHST- 2024/10/04 00:00 [accepted] PHST- 2024/10/15 07:19 [medline] PHST- 2024/10/15 00:20 [pubmed] PHST- 2024/10/14 23:47 [entrez] PHST- 2024/10/14 00:00 [pmc-release] AID - 10.1186/s12889-024-20285-3 [pii] AID - 20285 [pii] AID - 10.1186/s12889-024-20285-3 [doi] PST - epublish SO - BMC Public Health. 2024 Oct 14;24(1):2812. doi: 10.1186/s12889-024-20285-3. PMID- 39402064 OWN - NLM STAT- MEDLINE DCOM- 20241014 LR - 20241018 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Oct 14 TI - Association of healthy eating index (HEI), alternative healthy eating index (AHEI) with antioxidant capacity of maternal breast milk and infant's urine: a cross-sectional study. PG - 24053 LID - 10.1038/s41598-024-73169-2 [doi] LID - 24053 AB - Maternal dietary quality may alter the nutrient content of breast milk. In this study, we aimed to investigate the relationship between the healthy eating index (HEI) and alternative healthy eating index (AHEI) of a breastfeeding mother's diet with the antioxidant profile of her breast milk and her infant's urine. This study included 300 healthy mother-infant pairs. The participants' dietary intake was estimated using a validated semi-quantitative food frequency questionnaire. The diet quality of participants was assessed using the HEI and AHEI. The total antioxidant content of the breast milk and infant's urine was evaluated using ferric reducing antioxidant power (FRAP), 2, 2'-diphenyl-1-picrylhydrazyl (DPPH), thiobarbituric acid reactive substances (TBARs), and Thiol quantification assays. After adjusting for confounding factors, the odds of a low malondialdehyde (MDA) content of breast milk were significantly higher in the highest quartile of HEI than in the lowest quartile. The odds of low DPPH and FRAP in infant urine decreased in the highest quartile of HEI compared to the lowest quartile. No significant relationship was found between AHEI and antioxidant levels of breast milk and the infant's urine. Our findings demonstrate that a high quality diet of breastfeeding mothers, identified by a higher HEI, can affect the oxidant-antioxidant balance of a mother's breast milk and her infant's urine. CI - (c) 2024. The Author(s). FAU - Asadi, Zahra AU - Asadi Z AD - Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. FAU - Bahrami, Afsane AU - Bahrami A AD - Clinical Research Development Unit, Faculty of Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Clinical Research Development Unit of Akbar Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Zarban, Asghar AU - Zarban A AD - Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran. AD - Clinical Biochemistry Department, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran. FAU - Asadian, Amir Hassan AU - Asadian AH AD - Department of Horticultural Science, Faculty of Agriculture, University of Birjand, Birjand, Iran. FAU - Ferns, Gordon A AU - Ferns GA AD - Brighton and Sussex Medical School, Division of Medical Education, Falmer, Sussex, Brighton, BN1 9PH, UK. FAU - Karbasi, Samira AU - Karbasi S AD - Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran. s.karbasi@bums.ac.ir. LA - eng PT - Journal Article DEP - 20241014 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Antioxidants) RN - 4Y8F71G49Q (Malondialdehyde) SB - IM MH - Humans MH - *Milk, Human/chemistry/metabolism MH - Female MH - *Antioxidants/analysis/metabolism MH - Cross-Sectional Studies MH - Adult MH - Infant MH - *Diet, Healthy MH - Breast Feeding MH - Male MH - Malondialdehyde/urine/analysis PMC - PMC11473730 OTO - NOTNLM OT - AHEI OT - Breast milk OT - Breastfeeding mothers OT - HEI OT - Oxidant-antioxidant balance OT - Urine COIS- The authors declare no competing interests. EDAT- 2024/10/15 00:20 MHDA- 2024/10/15 00:21 PMCR- 2024/10/14 CRDT- 2024/10/14 23:18 PHST- 2024/06/13 00:00 [received] PHST- 2024/09/16 00:00 [accepted] PHST- 2024/10/15 00:21 [medline] PHST- 2024/10/15 00:20 [pubmed] PHST- 2024/10/14 23:18 [entrez] PHST- 2024/10/14 00:00 [pmc-release] AID - 10.1038/s41598-024-73169-2 [pii] AID - 73169 [pii] AID - 10.1038/s41598-024-73169-2 [doi] PST - epublish SO - Sci Rep. 2024 Oct 14;14(1):24053. doi: 10.1038/s41598-024-73169-2. PMID- 39401060 OWN - NLM STAT- MEDLINE DCOM- 20250502 LR - 20260924 IS - 1572-0241 (Electronic) IS - 0002-9270 (Print) IS - 0002-9270 (Linking) VI - 120 IP - 5 DP - 2025 May 1 TI - Development and Validation of a Pediatric Celiac Disease-Specific Quality of Life Measure. PG - 1116-1126 LID - 10.14309/ajg.0000000000003132 [doi] AB - INTRODUCTION: Quality of life (QOL) is critical in screening and management of chronic medical conditions, including celiac disease (CD). The aim of this project was to develop a CD-specific pediatric QOL measure (Celiac Disease Life Inventory of Family Experiences [CDLIFE]) with parallel self-report and parent-report forms by generating items through concept elicitation interviews, iterative refinement using cognitive debriefing interviews, and evaluating its psychometric properties and validity. METHODS: Concept elicitation interviews were conducted to develop items (9 youth ages 8-19 years with CD; 10 parents of youth with CD), followed by cognitive interviews with additional stakeholders (3 youth with CD, 3 parents, and 8 clinicians) and item administration (parent/youth reports: n = 103/102). Analyses included response frequencies, internal consistency reliability, exploratory factor analyses, and correlations with related measures (Patient-Reported Outcomes Measurement Information System, Pediatric Quality of Life Inventory, and Gluten-Free Diet-Visual Analog Scale). RESULTS: From concept elicitation interviews, 42 youth and 45 parent items were developed. Cognitive debriefing interviews yielded 36 refined items. Psychometric analyses identified 15 items to remove due to ceiling/floor effects, poor item-to-test correlations, and youth-parent mismatch or conceptual mismatch. Total score internal consistency was high (alphas = 0.89-0.90). A 4-factor model solution had the best fit (Social Impact, External Support, Adaptive Vigilance, Eating Behaviors/Adjustment) with a fifth single-item domain (Financial Resources). The final CDLIFE (21 items) total scores correlated with most related measures in expected directions for parent and youth forms. DISCUSSION: The CDLIFE may facilitate insight into CD-specific QOL for youth ages 2-18 years, capturing important dimensions of physical and socioemotional health. Administering the CDLIFE will help identify and track families needing support. CI - Copyright (c) 2024 by The American College of Gastroenterology. FAU - Coburn, Shayna AU - Coburn S AUID- ORCID: 0000-0001-9526-3580 AD - Center for Translational Research, Children's National Hospital, Washington, District of Columbia, USA. AD - The George Washington School of Medicine and Health Sciences, Washington, District of Columbia, USA. FAU - Trojanowski, Paige J AU - Trojanowski PJ AUID- ORCID: 0000-0002-4118-9087 AD - Center for Translational Research, Children's National Hospital, Washington, District of Columbia, USA. FAU - Vagadori, Jack AU - Vagadori J AUID- ORCID: 0000-0001-7443-6438 AD - Center for Translational Research, Children's National Hospital, Washington, District of Columbia, USA. FAU - Hinds, Pamela AU - Hinds P AD - Center for Translational Research, Children's National Hospital, Washington, District of Columbia, USA. AD - The George Washington School of Medicine and Health Sciences, Washington, District of Columbia, USA. AD - Department of Nursing Science, Professional Practice & Quality, Children's National Hospital, Washington, District of Columbia, USA. FAU - Germone, Monique AU - Germone M AUID- ORCID: 0000-0001-6827-5551 AD - Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA. AD - University of Colorado School of Medicine, Aurora, Colorado, USA . FAU - Liu, Edwin AU - Liu E AUID- ORCID: 0000-0003-3591-8922 AD - Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA. AD - University of Colorado School of Medicine, Aurora, Colorado, USA . FAU - Streisand, Randi AU - Streisand R AD - Center for Translational Research, Children's National Hospital, Washington, District of Columbia, USA. AD - The George Washington School of Medicine and Health Sciences, Washington, District of Columbia, USA. FAU - Bost, James AU - Bost J AD - Center for Translational Research, Children's National Hospital, Washington, District of Columbia, USA. AD - The George Washington School of Medicine and Health Sciences, Washington, District of Columbia, USA. LA - eng GR - K26 DK138330/DK/NIDDK NIH HHS/United States GR - UL1TR001876 (Pilot Subaward)/TR/NCATS NIH HHS/United States GR - UL1 TR001876/TR/NCATS NIH HHS/United States GR - K23DK129826/DK/NIDDK NIH HHS/United States GR - K23 DK129826/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Validation Study DEP - 20241014 PL - United States TA - Am J Gastroenterol JT - The American journal of gastroenterology JID - 0421030 SB - IM MH - Humans MH - *Celiac Disease/psychology/diet therapy MH - *Quality of Life MH - Child MH - Adolescent MH - Female MH - Male MH - Psychometrics MH - Young Adult MH - Reproducibility of Results MH - Parents/psychology MH - Self Report MH - Surveys and Questionnaires MH - Diet, Gluten-Free MH - Patient Reported Outcome Measures PMC - PMC11994830 MID - NIHMS2028920 OTO - NOTNLM OT - parents OT - pediatric OT - survey OT - youth COIS- Disclosures The authors have no potential conflicts of interest to disclose. EDAT- 2024/10/14 12:22 MHDA- 2025/05/02 12:33 PMCR- 2026/05/01 CRDT- 2024/10/14 11:53 PHST- 2024/06/17 00:00 [received] PHST- 2024/10/03 00:00 [accepted] PHST- 2025/05/02 12:33 [medline] PHST- 2024/10/14 12:22 [pubmed] PHST- 2024/10/14 11:53 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - 00000434-202505000-00029 [pii] AID - 10.14309/ajg.0000000000003132 [doi] PST - ppublish SO - Am J Gastroenterol. 2025 May 1;120(5):1116-1126. doi: 10.14309/ajg.0000000000003132. Epub 2024 Oct 14. PMID- 39400691 OWN - NLM STAT- MEDLINE DCOM- 20241126 LR - 20241130 IS - 1573-2649 (Electronic) IS - 0962-9343 (Print) IS - 0962-9343 (Linking) VI - 33 IP - 12 DP - 2024 Dec TI - Evaluating anchor variables and variation in meaningful score differences for PROMIS((R)) Pediatric measures in children and adolescents living with a rheumatic disease. PG - 3449-3457 LID - 10.1007/s11136-024-03800-2 [doi] AB - PURPOSE: Meaningful score differences (MSDs), as defined by recent FDA guidance, can improve the interpretation of outcome measure scores and score changes. Well-accepted methods for estimating MSDs typically rely on external anchor variables, but the applications of these methods are limited in children and adolescents with rheumatic diseases. This project explored multiple candidate anchors for the PROMIS((R)) Pediatric measures of Physical Activity, Fatigue, Pain Interference, and Mobility for children with juvenile idiopathic arthritis (JIA) or systemic lupus erythematosus (SLE). METHODS: Longitudinal data were extracted from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry. Candidate anchors included patient-reported domain-specific global impressions of change (GIC) along with other parent- and clinician-reported variables. Prior to MSD estimation, the quality of the anchors was assessed using a priori criteria (correlation >/=0.30, n>/=10, <10% missing). Anchors meeting criteria were used to calculate MSDs. RESULTS: Among 289 children with JIA and 47 with SLE, the GIC did not meet criteria inhalf of the scenarios. Other candidate anchors performed slightly better. The calculated MSDs varied by external anchor across measures, diagnoses, and direction of change (better vs worse). CONCLUSIONS: Many of the candidate external anchoring variables did not meet pre-specified criteria for calculating MSDs. Even for those that did, the choice of anchoring variable had a strong impact on the estimated MSD value and were different from other published values. As in adults, establishing pediatric MSDs requires selection of high-quality anchors, as changes in the variables used as anchors can impact MSD values and any subsequent score interpretations. CI - (c) 2024. The Author(s). FAU - Zigler, C K AU - Zigler CK AUID- ORCID: 0000-0002-8996-7757 AD - Department of Population Health Sciences, Duke University School of Medicine, Durham, NC, USA. cek53@pitt.edu. AD - Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, USA. cek53@pitt.edu. FAU - Li, Z AU - Li Z AD - Department of Population Health Sciences, Duke University School of Medicine, Durham, NC, USA. FAU - Hernandez, A AU - Hernandez A AD - Department of Population Health Sciences, Duke University School of Medicine, Durham, NC, USA. FAU - Randell, R L AU - Randell RL AUID- ORCID: 0000-0002-8009-8209 AD - Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA. AD - Duke Clinical Research Institute, Duke University School of Medicine, Durham, USA. FAU - Mann, C M AU - Mann CM AD - Duke Clinical Research Institute, Duke University School of Medicine, Durham, USA. FAU - Weitzman, E AU - Weitzman E AD - Division of Adolescent/Young Adult Medicine, Boston Children's Hospital, Boston, MA, USA. AD - Department of Pediatrics, Harvard Medical School, Boston, MA, USA. FAU - Schanberg, L E AU - Schanberg LE AUID- ORCID: 0000-0002-1913-6472 AD - Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA. AD - Duke Clinical Research Institute, Duke University School of Medicine, Durham, USA. FAU - von Scheven, E AU - von Scheven E AD - Department of Pediatrics, University of California, San Francisco, CA, USA. FAU - Reeve, B B AU - Reeve BB AD - Department of Population Health Sciences, Duke University School of Medicine, Durham, NC, USA. AD - Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA. AD - Duke Clinical Research Institute, Duke University School of Medicine, Durham, USA. LA - eng GR - U19 AR069522/AR/NIAMS NIH HHS/United States GR - U19AR069522/AR/NIAMS NIH HHS/United States PT - Journal Article DEP - 20241014 PL - Netherlands TA - Qual Life Res JT - Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation JID - 9210257 SB - IM MH - Humans MH - Adolescent MH - Child MH - Female MH - Male MH - *Arthritis, Juvenile MH - Rheumatic Diseases MH - Lupus Erythematosus, Systemic MH - Surveys and Questionnaires/standards MH - Patient Reported Outcome Measures MH - Longitudinal Studies MH - Quality of Life MH - Registries MH - Psychometrics MH - Severity of Illness Index PMC - PMC11599406 OTO - NOTNLM OT - Meaningful change OT - Minimal score differences OT - Pediatrics OT - Quality of life OT - Symptoms COIS- Declarations. Conflict of interest: Dr. Zigler has received consultant honoraria from Emmes Corporation and travel support from the Rett Syndrome Research Trust. Dr. Randell receives support from the NIH and Lupus Foundation of America, and her spouse has financial relationships with Merck & Co and Biogen. Dr. Schanberg has research funding from BMS and PCORI. She serves on the DSMBs for Sanofi (Sarilumab) and UCB (certolizumab). Dr. von Scheven receives financial support from the Childhood Arthritis and Rheumatology Research Alliance for her role on Executive Committee. Dr. Reeve, in the past five years, has received consultant honoraria from Novartis Pharmaceuticals, the University of Florida, Northwestern University, Johns Hopkins University, and Regeneron Pharmaceuticals. Authors Dr. Weitzman, C.M. Mann, Z. Li, and A. Hernandez declare they have no financial interests. EDAT- 2024/10/14 12:22 MHDA- 2024/11/26 12:30 PMCR- 2024/10/14 CRDT- 2024/10/14 11:09 PHST- 2024/09/29 00:00 [accepted] PHST- 2024/11/26 12:30 [medline] PHST- 2024/10/14 12:22 [pubmed] PHST- 2024/10/14 11:09 [entrez] PHST- 2024/10/14 00:00 [pmc-release] AID - 10.1007/s11136-024-03800-2 [pii] AID - 3800 [pii] AID - 10.1007/s11136-024-03800-2 [doi] PST - ppublish SO - Qual Life Res. 2024 Dec;33(12):3449-3457. doi: 10.1007/s11136-024-03800-2. Epub 2024 Oct 14. PMID- 39399505 OWN - NLM STAT- MEDLINE DCOM- 20241014 LR - 20260825 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 15 DP - 2024 TI - Dietary intakes and nutritional issues in inborn errors of immunity: a systematic review. PG - 1408985 LID - 10.3389/fimmu.2024.1408985 [doi] LID - 1408985 AB - INTRODUCTION: Inborn errors of immunity (IEI) are characterized by an inherited dysregulation or absence of immune system components that can manifest clinically in complications that predispose an individual to feeding difficulties or impaired swallowing, digestion, and absorption. Treatment side-effects or altered requirements may further impair nutritional status. While adequate nutrition is necessary for optimal growth and immune function, little is known about nutritional intakes in IEI, and best practice nutrition guidelines are limited. This review aimed to synthesize current evidence on the dietary intakes, anthropometry and nutritional biochemistry in individuals with an IEI. METHODS: A systematic review of literature published from database inception to March 2023 was conducted in accordance with the PRISMA guidelines. Articles eligible for inclusion reported anthropometric, biochemical, or dietary intake-related measures in pediatric or adult patients with a diagnosed IEI. Identified articles were screened for eligibility; data was synthesized descriptively. RESULTS: A total of 4488 studies were retrieved of which 34 were included. Across studies, 2894 IEI individuals were included (age range 4 weeks to 83y), predominantly focusing on ataxia telangiectasia (AT) and common variable immunodeficiency (CVID). A significant association between inadequate energy intakes and IEI was identified (n=6 studies); however, there was significant variability in adequacy of macro- and micronutrients across studies. Patients with IEI were at risk of malnutrition (range 30% to 70%); although anthropometric assessment measures were not consistent across studies. Biochemical assessments found patients were also at risk of micronutrient deficiencies including vitamin D. DISCUSSION: This review identified few studies assessing dietary intakes, anthropometry and nutritional biochemistry in patients with IEI, with considerable heterogeneity across studies. Future longitudinal studies using consistent validated dietary assessment tools and anthropometric measures in diverse IEI patient populations are needed. This review reinforces the need for dietetic input in people with an IEI and the development evidence-based clinical practice guidelines for people with an IEI. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO, identifier CRD42023412365. CI - Copyright (c) 2024 Freer, Bhatia, Preece and Pursey. FAU - Freer, Macey AU - Freer M AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia. FAU - Bhatia, Rani AU - Bhatia R AD - John Hunter Children's Hospital, Hunter New England Health, New Lambton Heights, NSW, Australia. AD - School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia. FAU - Preece, Kahn AU - Preece K AD - John Hunter Children's Hospital, Hunter New England Health, New Lambton Heights, NSW, Australia. AD - School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia. FAU - Pursey, Kirrilly M AU - Pursey KM AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia. AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. AD - Hunter New England Health, New Lambton Heights, NSW, Australia. LA - eng PT - Journal Article PT - Systematic Review DEP - 20240927 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 SB - IM MH - Humans MH - *Nutritional Status MH - Child MH - Adult MH - Child, Preschool MH - Adolescent MH - Diet MH - Infant MH - Young Adult MH - Middle Aged MH - Aged MH - Female MH - Infant, Newborn MH - Male PMC - PMC11466791 OTO - NOTNLM OT - dietary intake OT - inborn errors of immunity OT - nutritional issues OT - nutritional status OT - primary immunodeficiency COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/10/14 16:18 MHDA- 2024/10/14 16:19 PMCR- 2024/01/01 CRDT- 2024/10/14 07:19 PHST- 2024/03/29 00:00 [received] PHST- 2024/09/09 00:00 [accepted] PHST- 2024/10/14 16:19 [medline] PHST- 2024/10/14 16:18 [pubmed] PHST- 2024/10/14 07:19 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - 10.3389/fimmu.2024.1408985 [doi] PST - epublish SO - Front Immunol. 2024 Sep 27;15:1408985. doi: 10.3389/fimmu.2024.1408985. eCollection 2024. PMID- 39398882 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241015 IS - 1976-1457 (Print) IS - 2005-6168 (Electronic) IS - 1976-1457 (Linking) VI - 18 IP - 5 DP - 2024 Oct TI - Mukbang media: correlations with the dietary behavior of children and adolescents in Korea. PG - 674-686 LID - 10.4162/nrp.2024.18.5.674 [doi] AB - BACKGROUND/OBJECTIVES: Mukbang, a trend originating in South Korea and gaining global popularity, could influence children's food choices and eating habits. This study analyzed the correlation between Mukbang viewing time in children and adolescents, their meal consumption frequency, nutrition quotient (NQ), and frequency of food intake. SUBJECTS/METHODS: From July to August 2022, this cross-sectional study investigated upper elementary students (ages 9-11 yrs) and adolescents (aged 12-18 yrs) using an online survey. The survey items included key demographic factors, Mukbang viewing frequency and duration, frequency of main meal consumption, commonly consumed foods, and the validated NQ, which was used to assess food intake quality. Multiple linear regression analysis was used to explore the link between Mukbang viewing and nutritional habits. RESULTS: Weekly Mukbang viewing time was significantly correlated with eating habits after adjusting for gender, age, physical activity frequency past week, household income, and primary caregiver's level of education. Increased Mukbang viewing time correlated with reduced frequency of breakfast (P for trend < 0.001) and dinner (P for trend = 0.012), while the frequency of eating out (P for trend < 0.001) and late-night snacking (P for trend = 0.008) increased. Higher Mukbang viewing time notably decreased scores in the moderation domain (P for trend < 0.001), in the practice domain (P for trend = 0.031), and overall NQ (P for trend < 0.001). It also significantly elevated intake of sweets (P for trend = 0.001), Korean-style street food, Western-style fast food, instant noodles, sweetened beverages, caffeinated beverages, and fruit and vegetable juices (P for trend < 0.001). CONCLUSION: This study identifies a negative correlation between Mukbang viewing and eating habits among Korean children and adolescents. The results indicate the importance of incorporating children and adolescents' media usage and environmental factors on dietary education and the development of policy programs. CI - (c)2024 The Korean Nutrition Society and the Korean Society of Community Nutrition. FAU - Jang, Eunjin AU - Jang E AUID- ORCID: 0000-0003-3926-4575 AD - Department of Food Science and Nutrition, Hallym University, Chuncheon 24252, Korea. AD - The Korean Institute of Nutrition, Hallym University, Chuncheon 24252, Korea. FAU - Ko, Eunji AU - Ko E AUID- ORCID: 0000-0003-1486-1007 AD - Department of Food Science and Nutrition, Hallym University, Chuncheon 24252, Korea. AD - The Korean Institute of Nutrition, Hallym University, Chuncheon 24252, Korea. FAU - Sim, Jiwon AU - Sim J AUID- ORCID: 0000-0003-2381-8641 AD - Department of Food Science and Nutrition, Hallym University, Chuncheon 24252, Korea. AD - The Korean Institute of Nutrition, Hallym University, Chuncheon 24252, Korea. FAU - Jeong, Minjeong AU - Jeong M AUID- ORCID: 0009-0005-0686-1666 AD - Department of Food Science and Nutrition, Hallym University, Chuncheon 24252, Korea. AD - The Korean Institute of Nutrition, Hallym University, Chuncheon 24252, Korea. FAU - Park, Sohyun AU - Park S AUID- ORCID: 0000-0001-6009-1002 AD - Department of Food Science and Nutrition, Hallym University, Chuncheon 24252, Korea. AD - The Korean Institute of Nutrition, Hallym University, Chuncheon 24252, Korea. LA - eng PT - Journal Article DEP - 20240822 PL - Korea (South) TA - Nutr Res Pract JT - Nutrition research and practice JID - 101311052 PMC - PMC11464279 OTO - NOTNLM OT - Children OT - adolescents OT - eating behavior OT - screen time OT - social media COIS- Conflict of Interest: The authors declare no potential conflicts of interests. EDAT- 2024/10/14 16:51 MHDA- 2024/10/14 16:52 PMCR- 2024/10/01 CRDT- 2024/10/14 07:00 PHST- 2024/01/15 00:00 [received] PHST- 2024/05/23 00:00 [revised] PHST- 2024/07/08 00:00 [accepted] PHST- 2024/10/14 16:52 [medline] PHST- 2024/10/14 16:51 [pubmed] PHST- 2024/10/14 07:00 [entrez] PHST- 2024/10/01 00:00 [pmc-release] AID - 10.4162/nrp.2024.18.5.674 [doi] PST - ppublish SO - Nutr Res Pract. 2024 Oct;18(5):674-686. doi: 10.4162/nrp.2024.18.5.674. Epub 2024 Aug 22. PMID- 39397636 OWN - NLM STAT- MEDLINE DCOM- 20251016 LR - 20260206 IS - 1421-9832 (Electronic) IS - 1018-8665 (Print) IS - 1018-8665 (Linking) VI - 241 IP - Suppl. 1 DP - 2025 TI - Hidradenitis Suppurativa Prevalence in Algeria: A Multicenter Cross-Sectional Study. PG - 9-13 LID - 10.1159/000539599 [doi] AB -

Introduction: Although there has been an expansion of knowledge on HS (HS), data about the disease is largely based on Western population and no relevant African or Asian studies are available. METHODS: We conducted a descriptive, cross-sectional, multicenter study, as part of GHiSA (Global HS Atlas) initiative, to assess the epidemiologic profile of HS in an Algerian population. Healthy adults accompanying patients undergoing care in non-dermatological wards were approached and invited to complete a self-administered questionnaire. Subsequently, a clinical assessment was performed by an in-person dermatologists for all screen-positive participants and ten percent of the screen-negative ones. RESULTS: A total of 1,434 participants were included in this study. The prevalence of HS among Algerian adults was 0.77%. Compared to non-HS group, no significant difference was found regarding gender, age, body mass index, and smoker status. Both the sensitivity (100%) and the specificity (97%) of the HS screening questionnaire were excellent. CONCLUSION: The prevalence of HS in Algeria is very close to that of Australia (0.8%) and Europe (0.7%) and almost the same prevalence found by Ghanaian study (other GHiSA study from Africa). The results of this study demonstrate also the reliability and validity of GHiSA questionnaire as HS data collection instrument.

. CI - (c) 2025 The Author(s). Published by S. Karger AG, Basel. FAU - Chehad, Ahmed Samaouel AU - Chehad AS AD - Department of dermatology, University-hospital of Constantine, Faculty of Medicine, Constantine-3 University, El Khroub, Algeria. FAU - Zobiri, Samira AU - Zobiri S AD - Department of dermatology, Mustapha University Hospital Center, Faculty of Medicine, Alger-1 University, Sidi M'Hamed, Algeria. FAU - Bouazzi, Dorra AU - Bouazzi D AD - Department of Dermatology, Zealand University Hospital, Roskilde, Denmark. AD - Department of Clinical Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark. AD - Section for Biostatistics and Evidence-Based Research, the Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark. FAU - Medianfar, Cecilia E AU - Medianfar CE AD - Department of Dermatology, Zealand University Hospital, Roskilde, Denmark. AD - Department of Clinical Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark. FAU - Christensen, Robin AU - Christensen R AD - Section for Biostatistics and Evidence-Based Research, the Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark. AD - Research Unit of Rheumatology, Department of Clinical Research, Odense University Hospital, University of Southern Denmark, Odense, Denmark. AD - Department of Clinical Research, Cochrane Denmark & Centre for Evidence-Based Medicine Odense (CEBMO), University of Southern Denmark, Odense, Denmark. FAU - Jemec, Gregor B E AU - Jemec GBE AD - Department of Dermatology, Zealand University Hospital, Roskilde, Denmark. AD - Department of Clinical Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark. FAU - Serradj, Amina AU - Serradj A AD - Department of dermatology, University Hospital of Oran, Faculty of Medicine, Oran-1 University, Oran, Algeria. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20250707 PL - Switzerland TA - Dermatology JT - Dermatology (Basel, Switzerland) JID - 9203244 SB - IM MH - Humans MH - Algeria/epidemiology MH - Cross-Sectional Studies MH - Male MH - Female MH - Adult MH - Prevalence MH - *Hidradenitis Suppurativa/epidemiology/diagnosis MH - Middle Aged MH - Young Adult MH - Surveys and Questionnaires MH - Adolescent MH - Aged PMC - PMC12233973 OTO - NOTNLM OT - Epidemiological study OT - GHiSA OT - Hidradenitis suppurativa OT - North Africa OT - Prevalence study OT - Race differences OT - Risk factors COIS- A.S.C. declares that he received honorarium and consulting fee from AbbVie, ACM, Alliance, Beit Jala, Galderma, Beker, Janssen-Cilag, Leo-Pharma, Lilly, Novartis, Pfizer, Pierre Fabre, Sanofi Genzyme and Takeda. G.B.E.J. has received honoraria from AbbVie, Chemocentryx, Coloplast, Incyte, Inflarx, Novartis, Pierre Fabre and UCB for participation on advisory boards, and grants from Abbvie, Astra-Zeneca, Inflarx, Janssen-Cilag, Leo Pharma, Novartis, Regeneron and Sanofi, for participation as an investigator, and received speaker honoraria from AbbVie, Boehringer-Ingelheim, Galderma, and MSD. He has also received unrestricted departmental grants from Abbvie, Leo Pharma, and Novartis. D.B. declares that UCB Nordic has paid for EADV 2022 and EADV 2023 congress participation. Received teaching honoraria from UCB Nordic. The remaining authors have no conflicts of interest to declare. EDAT- 2024/10/14 10:17 MHDA- 2025/10/16 18:35 PMCR- 2025/07/07 CRDT- 2024/10/14 04:56 PHST- 2024/01/26 00:00 [received] PHST- 2024/05/30 00:00 [accepted] PHST- 2025/10/16 18:35 [medline] PHST- 2024/10/14 10:17 [pubmed] PHST- 2024/10/14 04:56 [entrez] PHST- 2025/07/07 00:00 [pmc-release] AID - 000539599 [pii] AID - 539599 [pii] AID - 10.1159/000539599 [doi] PST - ppublish SO - Dermatology. 2025;241(Suppl. 1):9-13. doi: 10.1159/000539599. Epub 2025 Jul 7. PMID- 39396763 OWN - NLM STAT- MEDLINE DCOM- 20241105 LR - 20260813 IS - 1095-8304 (Electronic) IS - 0195-6663 (Print) IS - 0195-6663 (Linking) VI - 203 DP - 2024 Dec 1 TI - Development of the Baby Behaviors when Satiated (BABES) behavioral coding scheme. PG - 107704 LID - S0195-6663(24)00507-5 [pii] LID - 10.1016/j.appet.2024.107704 [doi] AB - Current infant feeding recommendations promote responsive feeding, wherein caregivers respond to infants' cues to determine feeding pace and duration, to support infant self-regulation and healthy weight outcomes. A central tenet of responsive feeding is that infants will effectively signal hunger, receptiveness to feeding, needs to disengage from feeding, and satiation, yet there is a lack of research available to support this assumption. Rather, previous research illustrates substantial variability exists for the extent to which infants exhibit behavioral cues during feeding and that many mothers feel their infants do not clearly communicate satiation, suggesting certain caregivers need tailored support to understand their infants' needs during feeding interactions. As a first step toward addressing this research gap, we developed the Baby Behaviors when Satiated (BABES) coding scheme, a comprehensive tool that assesses infants' disengagement/satiation behaviors and mothers' responses to infant behaviors and feeding practices during mother-infant feeding interactions. The BABES was applied to 876 videos of bottle-feeding interactions from a prospective, longitudinal study of dyads observed when infants were 1, 2, 4, 6, 9, and 12 months old. Coders achieved moderate to strong inter-rater reliability. Descriptive analyses illustrated that the percentages of infants and mothers exhibiting different behaviors at each age were consistent with developmental trends noted in previous research. Application of this tool within future research holds the potential to create rich datasets allowing for description of intra- and inter-individual variability in infant and mother behaviors and how infants' and mothers' behaviors co-develop across the first year. CI - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Ventura, Alison K AU - Ventura AK AD - Department of Kinesiology & Public Health, Center for Health Research, Bailey College of Science and Mathematics, California Polytechnic State University, One Grand Ave, San Luis Obispo, CA, 93407, USA. Electronic address: akventur@calpoly.edu. FAU - Ross, Kevin J AU - Ross KJ AD - Department of Statistics, Bailey College of Science and Mathematics, California Polytechnic State University, One Grand Ave, San Luis Obispo, CA, 93407, USA. Electronic address: kjross@calpoly.edu. FAU - Miller, Alison L AU - Miller AL AD - Department of Health Behavior and Health Education, University of Michigan School of Public Health, 3718 SPH I, 1415 Washington Heights, Ann Arbor, MI, 48109-2029, USA. Electronic address: alimill@umich.edu. FAU - DeJesus, Jasmine M AU - DeJesus JM AD - Department of Psychology, University of North Carolina at Greensboro, 321 McIver Street, Greensboro, NC, 27412, USA. Electronic address: jmdejes2@uncg.edu. FAU - Tan, Cin Cin AU - Tan CC AD - Department of Psychology, University of Toledo, 2801 West Bancroft St, Toledo, OH, 43606-3390, USA. Electronic address: cincin.tan@utoledo.edu. FAU - Lumeng, Julie C AU - Lumeng JC AD - Department of Pediatrics, University of Michigan Medical School, 2800 Plymouth Road, Building 520, Ann Arbor, MI, 48109, USA. Electronic address: jlumeng@umich.edu. LA - eng GR - R01 HD084163/HD/NICHD NIH HHS/United States GR - R01 HD095135/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20241011 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Infant MH - Female MH - *Infant Behavior MH - Male MH - *Mother-Child Relations MH - *Mothers/psychology MH - Longitudinal Studies MH - *Feeding Behavior/psychology MH - Prospective Studies MH - Satiation MH - Adult MH - Bottle Feeding MH - Cues MH - Maternal Behavior/psychology MH - Reproducibility of Results MH - Child Development PMC - PMC12911498 MID - NIHMS2145940 OTO - NOTNLM OT - Behavioral coding scheme OT - Feeding practices OT - Infant feeding cues OT - Mother-infant feeding interactions OT - Responsive feeding OT - Satiation COIS- Declaration of competing interest The authors have no financial relationships or conflicts of interest to disclose. EDAT- 2024/10/14 00:20 MHDA- 2024/11/06 00:22 PMCR- 2026/02/17 CRDT- 2024/10/13 19:18 PHST- 2024/04/24 00:00 [received] PHST- 2024/08/30 00:00 [revised] PHST- 2024/10/04 00:00 [accepted] PHST- 2024/11/06 00:22 [medline] PHST- 2024/10/14 00:20 [pubmed] PHST- 2024/10/13 19:18 [entrez] PHST- 2026/02/17 00:00 [pmc-release] AID - S0195-6663(24)00507-5 [pii] AID - 10.1016/j.appet.2024.107704 [doi] PST - ppublish SO - Appetite. 2024 Dec 1;203:107704. doi: 10.1016/j.appet.2024.107704. Epub 2024 Oct 11. PMID- 39387906 OWN - NLM STAT- MEDLINE DCOM- 20241031 LR - 20261010 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 183 IP - 12 DP - 2024 Dec TI - Associations between sedentary types, sedentary patterns and cognitive ability in preschool children. PG - 5351-5362 LID - 10.1007/s00431-024-05813-y [doi] AB - The preschool years are a critical period for developing cognitive abilities such as reasoning, memorization, comprehension, quick thinking, and problem-solving. Sedentary behavior (SB) is known to be associated with cognitive development in preschool children. However, limited research has focused on how different types of SB (active, passive) and sedentary patterns (bouts, breaks) affect preschool children's cognitive abilities. This cross-sectional study aimed to investigate: (1) the relationship between sedentary types and preschoolers' cognitive abilities; and (2) the relationship between sedentary patterns and preschoolers' cognitive abilities. Preschoolers aged 3 to 6 years (n = 353) were recruited from 5 kindergartens in Changsha, Hunan, China. Sedentary types were reported by parents, sedentary patterns were measured by preschoolers wearing an ActiGraph wGT3X-BT for seven consecutive days, and cognitive abilities were assessed using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-IV). The relationships between variables were analyzed using multiple linear regression models. Non-screen-based active SB was associated with higher full-scale IQ and fluid reasoning index in boys and higher visual spatial index in girls. Screen-based active SB was negatively associated with overall cognitive ability. Passive SB potentially had a negative effect on overall cognitive ability, but screen-based passive SB was positively associated with higher fluid reasoning indices in girls. Preschoolers' cognitive ability was positively associated with sedentary breaks, but not with sedentary bouts. CONCLUSIONS: Not all types of SB are equal when examining optimal cognitive development in preschoolers. Frequent breaks from sedentary time were associated with better cognitive development. Encouraging more frequent breaks to interrupt prolonged SB may be a viable strategy for reducing sedentary time to promote optimal cognitive development. These findings should be further validated in larger prospective studies. WHAT IS KNOWN: * Sedentary behavior is not advantageous for cognitive development. WHAT IS NEW: * Not all types of sedentary behavior are harmful. * Active sedentary behaviors are beneficial to overall cognitive development, but screen-based active sedentary behaviors may negatively impact some areas of cognitive performance. * Cognitive abilities in preschoolers are associated with sedentary breaks, but not with sedentary bouts. CI - (c) 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Li, Dan AU - Li D AUID- ORCID: 0009-0000-3766-7464 AD - School of Physical Education, Hunan Normal University, Changsha, 410012, China. FAU - Chia, Michael AU - Chia M AUID- ORCID: 0000-0002-1289-0552 AD - Physical Education & Sports Science, National Institute of Education, Nanyang Technological University, Singapore, 637616, Singapore. michael.chia@nie.edu.sg. FAU - Low, Seow Ting AU - Low ST AUID- ORCID: 0009-0000-5253-8986 AD - Physical Education & Sports Science, National Institute of Education, Nanyang Technological University, Singapore, 637616, Singapore. FAU - Chua, Terence AU - Chua T AUID- ORCID: 0000-0001-8478-9683 AD - Physical Education & Sports Science, National Institute of Education, Nanyang Technological University, Singapore, 637616, Singapore. FAU - Ma, Jiameng AU - Ma J AUID- ORCID: 0000-0002-3686-4797 AD - Physical Education & Sports Science, National Institute of Education, Nanyang Technological University, Singapore, 637616, Singapore. AD - Faculty of Physical Education, Sendai University, Miyagi, 9891693, Japan. FAU - Kim, Hyunshik AU - Kim H AUID- ORCID: 0000-0003-3880-9342 AD - Physical Education & Sports Science, National Institute of Education, Nanyang Technological University, Singapore, 637616, Singapore. AD - Faculty of Physical Education, Sendai University, Miyagi, 9891693, Japan. FAU - Zhang, Lifang AU - Zhang L AD - School of Sport Science, Changsha Normal University, Changsha, 410100, China. FAU - Tian, Lili AU - Tian L AD - Rongsheng Huayucheng Kindergarten, Changsha, 410100, China. FAU - Li, Xianxiong AU - Li X AUID- ORCID: 0000-0001-5537-5027 AD - School of Physical Education, Hunan Normal University, Changsha, 410012, China. lixianxiong@hunnu.edu.cn. LA - eng GR - QL20220125/the Hunan Provincial Graduate Student Research and Innovation Program/ PT - Journal Article DEP - 20241010 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Sedentary Behavior MH - Child, Preschool MH - Female MH - Male MH - Cross-Sectional Studies MH - *Cognition/physiology MH - *Child Development/physiology MH - China MH - Child OTO - NOTNLM OT - Cognition OT - Preschooler OT - Sedentary behavior OT - Sedentary patterns OT - Sedentary types EDAT- 2024/10/13 21:10 MHDA- 2024/11/01 07:19 CRDT- 2024/10/10 11:15 PHST- 2024/04/29 00:00 [received] PHST- 2024/10/04 00:00 [accepted] PHST- 2024/09/29 00:00 [revised] PHST- 2024/11/01 07:19 [medline] PHST- 2024/10/13 21:10 [pubmed] PHST- 2024/10/10 11:15 [entrez] AID - 10.1007/s00431-024-05813-y [pii] AID - 10.1007/s00431-024-05813-y [doi] PST - ppublish SO - Eur J Pediatr. 2024 Dec;183(12):5351-5362. doi: 10.1007/s00431-024-05813-y. Epub 2024 Oct 10. PMID- 39391937 OWN - NLM STAT- MEDLINE DCOM- 20241011 LR - 20260312 IS - 1651-1999 (Electronic) IS - 0803-7051 (Linking) VI - 33 IP - 1 DP - 2024 Dec TI - Office BP measurement using conical cuffs in children and adolescents with obesity. PG - 2411294 LID - 10.1080/08037051.2024.2411294 [doi] AB - OBJECTIVE: Findings from adult studies suggest that tronco-conical cuffs provide more accurate blood pressure (BP) measurements in individuals with obesity. The aim of the present study was to examine differences in office blood pressure (BP) levels using conical cuffs compared to standard-shaped cylindrical cuffs in children and adolescents with obesity. DESIGN AND METHOD: We performed an observational study, including 37 children and adolescents with obesity, who were consequently recruited from the outpatient clinics of the Obesity and Cardiovascular Risk Unit at General University Hospital Consortium of Valencia. Arm circumference AC was measured in all participants, and the appropriate cuff size was selected for both conical and cylindrical cuffs. RESULTS: Mean participants' age was 11.8+/-2.5 years, mean BMI was 28.8+/-3.4 kg/m(2), mean BMI z-score was 2.12+/-0.32, and mean AC was 30.0+/-3.6 cm. There was no statistical significance in BP levels measured by cylindrical compared to conical cuffs (mean difference cylindrical-conical cuff was -0.22+/-6.55 mmHg for SBP, -0.02+/-0.81 for SBP z-score, -0.70+/-4.95 mmHg for DBP, and -0.06+/-0.44 for DBP z-score). A significant positive association was found between the measurements obtained by cylindrical and conical cuffs in both mean and z-score SBP and DBP values (p < 0.001). Bland-Altman analysis showed good agreement, with 94.6% of the values for all BP parameters lying between the limits of agreement. CONCLUSIONS: Although the use of conical cuffs in the study showed no advantage in enhancing the performance of BP measurements, they may be considered an alternative for office BP measurements in children and adolescents with obesity. Their reliability should be confirmed in larger populations and different settings. FAU - Evripidou, Kleo AU - Evripidou K AD - 1st Department of Pediatrics, Hippocratio General Hospital, Aristotle University Thessaloniki, Thessaloniki, Greece. FAU - Alvarez-Pitti, Julio AU - Alvarez-Pitti J AD - Pediatric Department, Consorcio Hospital General, University of Valencia, Valencia, Spain. AD - CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. FAU - De Blas-Zapata, Ana AU - De Blas-Zapata A AD - Pediatric Department, Consorcio Hospital General, University of Valencia, Valencia, Spain. FAU - Chainoglou, Athanasia AU - Chainoglou A AD - 1st Department of Pediatrics, Hippocratio General Hospital, Aristotle University Thessaloniki, Thessaloniki, Greece. FAU - Goulas, Ioannis AU - Goulas I AD - 1st Department of Pediatrics, Hippocratio General Hospital, Aristotle University Thessaloniki, Thessaloniki, Greece. FAU - Herberigs, Karel AU - Herberigs K AD - OMRON Healthcare Europe BV, Amsterdam, Netherlands. FAU - Hamdani, Gilad AU - Hamdani G AD - Nephrology and Hypertension Institute, Schneider Children's Medical Center, Petah Tikva, Israel. FAU - Stabouli, Stella AU - Stabouli S AUID- ORCID: 0000-0001-9843-8198 AD - 1st Department of Pediatrics, Hippocratio General Hospital, Aristotle University Thessaloniki, Thessaloniki, Greece. CN - HyperChildNET Working Group 1 LA - eng PT - Journal Article PT - Observational Study DEP - 20241011 PL - England TA - Blood Press JT - Blood pressure JID - 9301454 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Blood Pressure MH - *Blood Pressure Determination/methods/instrumentation MH - *Pediatric Obesity/physiopathology OAB - What is the context?Largely due to the childhood obesity epidemic, elevated blood pressure (BP) levels or hypertension are observed in a significant percentage of children and adolescents.Accurate BP measuring is a challenging process in this special population, and choosing the appropriate cuff is of major importance.In individuals with obesity, the cuff selection depends not only on the arm circumference but also on its shape. Arm's conicity, presented in obesity, makes it difficult to fit the cuff to the arm, increasing the likelihood of inaccurate BP measurements.The use of conical cuffs has been widely proposed in the adult population. BP values obtained with the common cuff, compared to the conical ones, seem to be higher, causing an overestimation of true BP levels.What is new?We conducted an observational study to evaluate differences in BP levels using conical cuffs compared to standard-shaped cylindrical cuffs in office BP measurement in children and adolescents with obesity.We did not find significant differences in BP levels between the two different shapes of cuffs, suggesting no advantage of using conical cuffs for office BP measurement in children and adolescents with obesity. Our results are contrary to several available studies in adults.BP measurement in paediatric patients with obesity using conical cuffs could enhance the correct diagnosis of hypertension. Still, available cuffs are currently designed for the adult population and may not fit paediatric patients' arms.What is the impact?This is the first study that examines the role of tronco-conical-shaped cuffs for BP measurement in paediatric patients.The characteristics of the optimal cuff for BP measurement are still a subject of debate, but we consider the shape of the cuff as crucial for obtaining reliable BP readings. Establishing the ideal characteristics of cone-shaped cuffs gives rise to further research for both clinicians and manufacturers. OABL- eng OTO - NOTNLM OT - Blood pressure OT - Obesity OT - adolescents OT - children OT - cuff OT - hypertension EDAT- 2024/10/11 06:23 MHDA- 2024/10/11 06:24 CRDT- 2024/10/11 04:33 PHST- 2024/10/11 06:24 [medline] PHST- 2024/10/11 06:23 [pubmed] PHST- 2024/10/11 04:33 [entrez] AID - 10.1080/08037051.2024.2411294 [doi] PST - ppublish SO - Blood Press. 2024 Dec;33(1):2411294. doi: 10.1080/08037051.2024.2411294. Epub 2024 Oct 11. PMID- 39391369 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241012 IS - 1664-042X (Print) IS - 1664-042X (Electronic) IS - 1664-042X (Linking) VI - 15 DP - 2024 TI - The oxygen uptake efficiency slope does not accurately predict V O(2peak) of children - the Arkansas Active Kids study. PG - 1358942 LID - 10.3389/fphys.2024.1358942 [doi] LID - 1358942 AB - BACKGROUND: Cardiorespiratory fitness (CRF) is a vital indicator of health. However, accurately measuring peak oxygen consumption ( V O(2peak)) to determine CRF in children can be challenging. The oxygen uptake efficiency slope (OUES) has been proposed as an alternative metric for predicting V O(2peak) in children, but its accuracy and agreement with measured V O(2peak) remain unclear. METHODS: A post hoc analysis was conducted in 94 children (ages 7-10 years) who completed an incremental cycle ergometer test to measure V O(2peak). Body composition (Dual-energy X-ray absorptiometry) was measured, and fat mass index (FMI, kg/m(2)) and fat-free mass index (FFMI, kg/m(2)) were calculated. OUES was determined using all respiratory data (OUES(100%)) collected during the cycle ergometer test and using data only up to 60% of heart rate reserve (OUES(60%HRR)). Regression equations to predict V O(2peak) (Pred- V O(2peak)) were derived from simple and multiple linear regression analysis. Bland-Altman analysis assessed the level of agreement between Pred- V O(2peak) and measured V O(2peak). RESULTS: OUES(60%HRR) (beta = 0.46, p < 0.0001), age (beta = 56.0, p = 0.0004), White race (beta = 173.3, p < 0.0003), FFMI (beta = 0.98.6, p < 0.000), and FMI (beta = -0.40.8, p < 0.000) were retained in the final model. The difference between measured V O(2peak) and Pred- V O(2peak) was not different from zero (p = 0.999). There was a positive association between the difference of measured V O(2peak) and Pred- V O(2peak) and the average of the two methods (beta = 0.79, p = 0.0028). CONCLUSION: There was no mean bias between measured V O(2peak) and Pred- V O(2peak). However, magnitude bias was present even after considering other significant predictors of V O(2peak) (FMI, FFMI, race, and age) in the regression equation. Caution is advised when using OUES to predict V O(2peak) in children. CI - Copyright (c) 2024 Edwards, Borsheim, Weber and Diaz. FAU - Edwards, Timothy AU - Edwards T AD - Arkansas Children's Nutrition Center, Little Rock, AR, United States. AD - Arkansas Children's Research Institute, Little Rock, AR, United States. FAU - Borsheim, Elisabet AU - Borsheim E AD - Arkansas Children's Nutrition Center, Little Rock, AR, United States. AD - Arkansas Children's Research Institute, Little Rock, AR, United States. AD - Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. AD - Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. FAU - Weber, Judith L AU - Weber JL AD - Arkansas Children's Research Institute, Little Rock, AR, United States. AD - Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. FAU - Diaz, Eva C AU - Diaz EC AD - Arkansas Children's Nutrition Center, Little Rock, AR, United States. AD - Arkansas Children's Research Institute, Little Rock, AR, United States. AD - Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. LA - eng PT - Journal Article DEP - 20240926 PL - Switzerland TA - Front Physiol JT - Frontiers in physiology JID - 101549006 PMC - PMC11464437 OTO - NOTNLM OT - bland altman OT - body composition OT - children OT - oxygen uptake efficiency slope OT - peak VO2 COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2024/10/11 06:22 MHDA- 2024/10/11 06:23 PMCR- 2024/09/26 CRDT- 2024/10/11 04:20 PHST- 2023/12/20 00:00 [received] PHST- 2024/09/11 00:00 [accepted] PHST- 2024/10/11 06:23 [medline] PHST- 2024/10/11 06:22 [pubmed] PHST- 2024/10/11 04:20 [entrez] PHST- 2024/09/26 00:00 [pmc-release] AID - 1358942 [pii] AID - 10.3389/fphys.2024.1358942 [doi] PST - epublish SO - Front Physiol. 2024 Sep 26;15:1358942. doi: 10.3389/fphys.2024.1358942. eCollection 2024. PMID- 39391080 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241012 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 15 DP - 2024 TI - Prenatal maternal mental health and resilience in the United Kingdom during the SARS-CoV-2 pandemic: a cross- national comparison. PG - 1411761 LID - 10.3389/fpsyt.2024.1411761 [doi] LID - 1411761 AB - INTRODUCTION: Prenatal mental health problems are associated with morbidity for the pregnant person, and their infants are at long-term risk for poor health outcomes. We aim to explore how the SARS-CoV-2 pandemic affected the mental health of pregnant people in the United Kingdom (UK), and to further identify resilience factors which may have contributed to varying mental health outcomes. We also aim to examine the quality of antenatal care provided during the pandemic in the UK and to identify potential inadequacies to enhance preparedness for future events. METHODS: During June-November 2020, we recruited 3666 individuals in the UK for the EPPOCH pregnancy cohort (Maternal mental health during the COVID-19 pandemic: Effect of the Pandemic on Pregnancy Outcomes and Childhood Health). Participants were assessed for depression, anxiety, anger and pregnancy-related anxiety using validated scales. Additionally, physical activity, social support, individualized support and personal coping ability of the respondents were assessed as potential resilience factors. RESULTS: Participants reported high levels of depression (57.05%), anxiety (58.04%) and anger (58.05%). Higher levels of social and individualized support and personal coping ability were associated with lower mental health challenges. Additionally, pregnant individuals in the UK experienced higher depression during the pandemic than that reported in Canada. Finally, qualitative analysis revealed that restrictions for partners and support persons during medical appointments as well as poor public health communication led to increased mental health adversities and hindered ability to make medical decisions. DISCUSSION: This study revealed increased mental health challenges among pregnant individuals in the UK during the SARS-CoV-2 pandemic. These results highlight the need for reassessing the mental health support measures available to pregnant people in the UK, both during times of crisis and in general. CI - Copyright (c) 2024 Datye, Smiljanic, Shetti, MacRae-Miller, van Teijlingen, Vinayakarao, Peters, Lebel, Tomfohr-Madsen, Giesbrecht, Khashu and Conrad. FAU - Datye, Swarali AU - Datye S AD - Institute of Microbiology, Infectious Diseases and Immunology, Charite-Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin Institute of Health, Berlin, Germany. AD - Neonatology and Pediatric Intensive Care, Faculty of Medicine, University of Augsburg, Augsburg, Germany. FAU - Smiljanic, Marko AU - Smiljanic M AD - Institute of Botany and Landscape Ecology, University of Greifswald, Greifswald, Germany. FAU - Shetti, Rohan AU - Shetti R AD - Faculty of Environment, Julius von Payer Institute for Arctic and Subarctic Research, Jan Evangelista Purkyne University, Usti nad Labem, Czechia. FAU - MacRae-Miller, Alison AU - MacRae-Miller A AD - Department of Family Medicine, University of British Columbia, Vancouver, BC, Canada. FAU - van Teijlingen, Edwin AU - van Teijlingen E AD - Centre for Midwifery and Women's Health, Bournemouth University, Bournemouth, United Kingdom. FAU - Vinayakarao, Latha AU - Vinayakarao L AD - University Hospitals Dorset NHS Foundation Trust, Poole, United Kingdom. FAU - Peters, Eva M J AU - Peters EMJ AD - Psychoneuroimmunology Laboratory, Department of Psychosomatic Medicine and Psychotherapy, Justus-Liebig University, Giessen, Germany. AD - Department of Psychosomatic Medicine and Psychotherapy, Charite Universitatsmedizin Berlin, Berlin, Germany. FAU - Lebel, Catherine AU - Lebel C AD - Department of Radiology, University of Calgary, Calgary, AB, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada. FAU - Tomfohr-Madsen, Lianne AU - Tomfohr-Madsen L AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada. AD - Department of Pediatrics, University of Calgary, Calgary, AB, Canada. AD - Department of Psychology, University of Calgary, Calgary, AB, Canada. FAU - Giesbrecht, Gerald AU - Giesbrecht G AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada. AD - Department of Pediatrics, University of Calgary, Calgary, AB, Canada. AD - Department of Psychology, University of Calgary, Calgary, AB, Canada. AD - Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada. FAU - Khashu, Minesh AU - Khashu M AD - University Hospitals Dorset NHS Foundation Trust, Poole, United Kingdom. FAU - Conrad, Melanie L AU - Conrad ML AD - Institute of Microbiology, Infectious Diseases and Immunology, Charite-Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin Institute of Health, Berlin, Germany. AD - Neonatology and Pediatric Intensive Care, Faculty of Medicine, University of Augsburg, Augsburg, Germany. AD - Institute for Medical Psychology, Charite-Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin Institute of Health, Berlin, Germany. LA - eng PT - Journal Article DEP - 20240926 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC11466367 OTO - NOTNLM OT - anxiety OT - depression OT - maternal mental health OT - mixed methods OT - pregnancy OT - resilience OT - social support COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2024/10/11 06:22 MHDA- 2024/10/11 06:23 PMCR- 2024/09/26 CRDT- 2024/10/11 04:15 PHST- 2024/04/03 00:00 [received] PHST- 2024/09/02 00:00 [accepted] PHST- 2024/10/11 06:23 [medline] PHST- 2024/10/11 06:22 [pubmed] PHST- 2024/10/11 04:15 [entrez] PHST- 2024/09/26 00:00 [pmc-release] AID - 10.3389/fpsyt.2024.1411761 [doi] PST - epublish SO - Front Psychiatry. 2024 Sep 26;15:1411761. doi: 10.3389/fpsyt.2024.1411761. eCollection 2024. PMID- 39389982 OWN - NLM STAT- MEDLINE DCOM- 20241010 LR - 20241013 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Oct 10 TI - The Ramp protocol: Uncovering individual differences in walking to an auditory beat using TeensyStep. PG - 23779 LID - 10.1038/s41598-024-72508-7 [doi] LID - 23779 AB - Intentionally walking to the beat of an auditory stimulus seems effortless for most humans. However, studies have revealed significant individual differences in the spontaneous tendency to synchronize. Some individuals tend to adapt their walking pace to the beat, while others show little or no adjustment. To fill this gap we introduce the Ramp protocol, which measures spontaneous adaptation to a change in an auditory rhythmic stimulus in a gait task. First, participants walk at their preferred cadence without stimulation. After several steps, a metronome is presented, timed to match the participant's heel-strike. Then, the metronome tempo progressively departs from the participant's cadence by either accelerating or decelerating. The implementation of the Ramp protocol required real-time detection of heel-strike and auditory stimuli aligned with participants' preferred cadence. To achieve this, we developed the TeensyStep device, which we validated compared to a gold standard for step detection. We also demonstrated the sensitivity of the Ramp protocol to individual differences in the spontaneous response to a tempo-changing rhythmic stimulus by introducing a new measure: the Response Score. This new method and quantification of spontaneous response to rhythmic stimuli holds promise for highlighting and distinguishing different profiles of adaptation in a gait task. CI - (c) 2024. The Author(s). FAU - Zagala, Agnes AU - Zagala A AD - International Laboratory for Brain, Music and Sound Research (BRAMS), Montreal, Canada. agnes.zagala@umontreal.ca. AD - Department of Psychology, University of Montreal, Montreal, Canada. agnes.zagala@umontreal.ca. AD - Centre for Research on Brain, Language and Music (CRBLM), Montreal, Canada. agnes.zagala@umontreal.ca. AD - Centre for Interdisciplinary Research on Brain and Learning (CIRCA), Montreal, Canada. agnes.zagala@umontreal.ca. FAU - Foster, Nicholas E V AU - Foster NEV AD - International Laboratory for Brain, Music and Sound Research (BRAMS), Montreal, Canada. AD - Centre for Research on Brain, Language and Music (CRBLM), Montreal, Canada. FAU - van Vugt, Floris T AU - van Vugt FT AD - International Laboratory for Brain, Music and Sound Research (BRAMS), Montreal, Canada. AD - Department of Psychology, University of Montreal, Montreal, Canada. AD - Centre for Research on Brain, Language and Music (CRBLM), Montreal, Canada. AD - Centre for Interdisciplinary Research on Brain and Learning (CIRCA), Montreal, Canada. FAU - Dal Maso, Fabien AU - Dal Maso F AD - International Laboratory for Brain, Music and Sound Research (BRAMS), Montreal, Canada. AD - School of Kinesiology and Physical Activity Sciences, University of Montreal, Montreal, Canada. AD - Centre for Interdisciplinary Research on Brain and Learning (CIRCA), Montreal, Canada. FAU - Dalla Bella, Simone AU - Dalla Bella S AD - International Laboratory for Brain, Music and Sound Research (BRAMS), Montreal, Canada. simone.dalla.bella@umontreal.ca. AD - Department of Psychology, University of Montreal, Montreal, Canada. simone.dalla.bella@umontreal.ca. AD - Centre for Research on Brain, Language and Music (CRBLM), Montreal, Canada. simone.dalla.bella@umontreal.ca. AD - Centre for Interdisciplinary Research on Brain and Learning (CIRCA), Montreal, Canada. simone.dalla.bella@umontreal.ca. AD - University of Economics and Human Sciences in Warsaw, Warsaw, Poland. simone.dalla.bella@umontreal.ca. LA - eng GR - RGPIN-2019-05453/Natural Sciences and Engineering Research Council of Canada/ PT - Journal Article DEP - 20241010 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Male MH - Female MH - *Walking/physiology MH - *Acoustic Stimulation/methods MH - Adult MH - *Gait/physiology MH - *Individuality MH - Young Adult MH - Adaptation, Physiological MH - Adolescent PMC - PMC11467224 OTO - NOTNLM OT - Auditory-motor synchronization OT - Gait OT - Individual differences OT - Ramp protocol OT - TeensyStep COIS- SDB is on the board of the BeatHealth company dedicated to the design and commercialization of technological tools for assessing rhythm capacity such as BAASTA tablet and implementing rhythm-based interventions. Other authors have no competing interest to disclose. EDAT- 2024/10/11 00:34 MHDA- 2024/10/11 00:35 PMCR- 2024/10/10 CRDT- 2024/10/10 23:16 PHST- 2024/03/27 00:00 [received] PHST- 2024/09/09 00:00 [accepted] PHST- 2024/10/11 00:35 [medline] PHST- 2024/10/11 00:34 [pubmed] PHST- 2024/10/10 23:16 [entrez] PHST- 2024/10/10 00:00 [pmc-release] AID - 10.1038/s41598-024-72508-7 [pii] AID - 72508 [pii] AID - 10.1038/s41598-024-72508-7 [doi] PST - epublish SO - Sci Rep. 2024 Oct 10;14(1):23779. doi: 10.1038/s41598-024-72508-7. PMID- 39388983 OWN - NLM STAT- MEDLINE DCOM- 20241130 LR - 20241130 IS - 1873-7358 (Electronic) IS - 1471-0153 (Linking) VI - 55 DP - 2024 Dec TI - Development and validation of the modified Yale Food Addiction Scale for Children 2.0. PG - 101927 LID - S1471-0153(24)00086-2 [pii] LID - 10.1016/j.eatbeh.2024.101927 [doi] AB - OBJECTIVE: Scientific interest in the concept of food addiction is growing, but more studies are needed in youth samples. Brief, psychometrically valid, and developmentally appropriate measures are needed to support the assessment of food addiction in large-scale studies of youth that need to minimize participant burden. While a brief version of the Yale Food Addiction Scale 2.0 (YFAS 2.0) exists for adults, no comparable scale exists for youth. Thus, the current study aimed to develop a brief and valid measure of food addiction for use in youth populations (the modified YFAS for children 2.0). METHOD: Data stem from the Food Addiction Denmark (FADK) Project, where random samples of 559 adolescents from the general population and 413 adolescents from a population with mental disorder completed the 35-item original YFAS for children 2.0 (YFAS-C 2.0). An abbreviated 13-item version was developed, and the psychometric properties of the modified YFAS-C 2.0 (mYFAS-C 2.0) were then evaluated. RESULTS: The mYFAS-C 2.0 exhibited a one-factor structure and was found to have sound psychometric properties regarding internal consistency and convergent, discriminant, and incremental validity. This was evident in both the general adolescent population sample and the sample of adolescents with mental disorders. CONCLUSIONS: The mYFAS-C 2.0 provides a brief and psychometrically valid measure of food addiction for youth, which may be beneficial for study designs (e.g., epidemiological samples) that aim to minimize participant burden. Future research on the test-retest reliability of the mYFAS-C 2.0 and its psychometric properties in younger children are important next steps. CI - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Horsager, Christina AU - Horsager C AD - Aalborg University Hospital, Psychiatry, Aalborg, Denmark. Electronic address: christina.pedersen@rn.dk. FAU - Gearhardt, Ashley N AU - Gearhardt AN AD - University of Michigan, Psychology, Ann Arbor, MI, USA. LA - eng PT - Journal Article PT - Validation Study DEP - 20240930 PL - United States TA - Eat Behav JT - Eating behaviors JID - 101090048 SB - IM MH - Humans MH - Adolescent MH - Female MH - *Food Addiction/psychology/diagnosis MH - Male MH - *Psychometrics/instrumentation MH - Child MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - Denmark MH - Psychiatric Status Rating Scales/standards OTO - NOTNLM OT - Adolescents OT - Food addiction OT - General population OT - Measurement-based care OT - Mental disorder OT - Obesity OT - Psychometrics OT - Surveys and questionnaires OT - Yale Food Addiction Scale for Children 2.0 COIS- Declaration of competing interest None. EDAT- 2024/10/11 07:19 MHDA- 2024/12/01 15:22 CRDT- 2024/10/10 18:10 PHST- 2024/06/24 00:00 [received] PHST- 2024/09/25 00:00 [revised] PHST- 2024/09/25 00:00 [accepted] PHST- 2024/12/01 15:22 [medline] PHST- 2024/10/11 07:19 [pubmed] PHST- 2024/10/10 18:10 [entrez] AID - S1471-0153(24)00086-2 [pii] AID - 10.1016/j.eatbeh.2024.101927 [doi] PST - ppublish SO - Eat Behav. 2024 Dec;55:101927. doi: 10.1016/j.eatbeh.2024.101927. Epub 2024 Sep 30. PMID- 39388222 OWN - NLM STAT- MEDLINE DCOM- 20241010 LR - 20260614 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 8 DP - 2024 Oct 10 TI - Design of a Temporally Augmented Text Messaging Bot to Improve Adolescents' Physical Activity and Engagement: Proof-of-Concept Study. PG - e60171 LID - 10.2196/60171 [doi] LID - e60171 AB - BACKGROUND: Digital interventions hold promise for improving physical activity in adolescents. However, a lack of empirical decision points (eg, timing of intervention prompts) is an evidence gap in the optimization of digital physical activity interventions. OBJECTIVE: The study examined the feasibility and acceptability, as well as the technical and functional reliability, of and participant engagement with a digital intervention that aligned its decision points to occur during times when adolescents typically exercise. This study also explored the impact of the intervention on adolescents' moderate to vigorous physical activity (MVPA) levels. Consistent with the Obesity-Related Behavioral Interventions Trials (ORBIT) model, the primary goal of the study was to identify opportunities to refine the intervention for preparation for future trials. METHODS: Ten adolescents completed a 7-day baseline monitoring period and Temporally Augmented Goal Setting (TAGS), a 20-day digital physical activity intervention that included a midday self-monitoring message that occurred when adolescents typically start to exercise (3 PM). Participants wore an accelerometer to measure their MVPA during the intervention. Participants completed questionnaires about the acceptability of the platform. Rates of recruitment and attrition (feasibility), user and technological errors (reliability), and engagement (average number of text message responses to the midday self-monitoring message) were calculated. The investigation team performed multilevel models to explore the effect of TAGS on MVPA levels from preintervention to intervention. In addition, as exploratory analyses, participants were matched to adolescents who previously completed a similar intervention, Network Underwritten Dynamic Goals Engine (NUDGE), without the midday self-monitoring message, to explore differences in MVPA between interventions. RESULTS: The TAGS intervention was mostly feasible, acceptable, and technically and functionally reliable. Adolescents showed adequate levels of engagement. Preintervention to intervention changes in MVPA were small (approximately a 2-minute change). Exploratory analyses revealed no greater benefit of TAGS on MVPA compared with NUDGE. CONCLUSIONS: TAGS shows promise for future trials with additional refinements given its feasibility, acceptability, technical and functional reliability, participants' rates of engagement, and the relative MVPA improvements. Opportunities to strengthen TAGS include reducing the burden of wearing devices and incorporating of other strategies at the 3 PM decision point. Further optimization of TAGS will inform the design of a Just-in-Time Adaptive Intervention for adolescent physical activity and prepare the intervention for more rigorous testing. CI - (c)Adrian Ortega, Christopher C Cushing. Originally published in JMIR Formative Research (https://formative.jmir.org), 10.10.2024. FAU - Ortega, Adrian AU - Ortega A AUID- ORCID: 0000-0003-1003-2156 AD - Center for Behavior Intervention Technologies, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States. FAU - Cushing, Christopher C AU - Cushing CC AUID- ORCID: 0000-0001-8452-8096 AD - Clinical Child Psychology Program, The University of Kansas, Lawrence, KS, United States. AD - Schiefelbusch Institute for Life Span Studies, The University of Kansas, Lawrence, KS, United States. LA - eng GR - T32 MH115882/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Intramural PT - Research Support, Non-U.S. Gov't DEP - 20241010 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - *Exercise MH - *Text Messaging MH - Surveys and Questionnaires MH - Proof of Concept Study MH - Reproducibility of Results MH - Health Promotion/methods MH - Feasibility Studies MH - Accelerometry PMC - PMC11502983 OTO - NOTNLM OT - SMS OT - adolescent OT - adolescents OT - augmented text messaging OT - bot OT - community OT - digital health OT - digital intervention OT - digital support OT - engagement OT - exercise OT - mHealth OT - physical activity OT - physical activity intervention OT - reliability OT - youth COIS- Conflicts of Interest: None declared. EDAT- 2024/10/10 22:18 MHDA- 2024/10/10 22:19 PMCR- 2024/10/10 CRDT- 2024/10/10 11:53 PHST- 2024/05/03 00:00 [received] PHST- 2024/08/20 00:00 [accepted] PHST- 2024/07/23 00:00 [revised] PHST- 2024/10/10 22:19 [medline] PHST- 2024/10/10 22:18 [pubmed] PHST- 2024/10/10 11:53 [entrez] PHST- 2024/10/10 00:00 [pmc-release] AID - v8i1e60171 [pii] AID - 10.2196/60171 [doi] PST - epublish SO - JMIR Form Res. 2024 Oct 10;8:e60171. doi: 10.2196/60171. PMID- 39385782 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241011 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 11 DP - 2024 TI - Changes in unhealthy food consumption among vulnerable elementary-aged children in the United States during the COVID-19 pandemic: a serial cross-sectional analysis. PG - 1468767 LID - 10.3389/fnut.2024.1468767 [doi] LID - 1468767 AB - OBJECTIVE: Several studies suggest that during the early pandemic, amidst socioeconomic instability, children from underserved families were more likely to resort to consuming cheaper, lower-quality foods with longer shelf lives. This study investigated the change in unhealthy food consumption across different phases (pre, early, mid) of the COVID-19 pandemic, and whether the strength of association between unhealthy food consumption and household socioeconomic disadvantage (HSED) varied across phases of the pandemic. METHODS: This study utilized serial cross-sectional data collected from low-income families enrolled in a school-based food co-op, Brighter Bites. Secondary data analysis included 5,384 surveys from families who had complete data: 3422 pre-pandemic, 944 from the early pandemic, and 1,018 mid-pandemic. Outcome measures included sugary food intake and convenience/fast food intake, each of which was operationalized as a scale using pre-validated items from the surveys. HSED was operationalized as a composite of parent employment, parent education, food insecurity, and participation in government programs; responses were categorized into low, medium, and high HSED groups for analysis. We examined the interaction between HSED and time period to explore how HSED and its association with dietary measures changed over the course of the pandemic. RESULTS: A significant linear negative trend, i.e., a decrease in consumption from pre-to-mid-pandemic period was seen in sugary food intake (p < 0.001), but not in convenience food intake. In data pooled across time-periods, both sugary food and convenience/fast food consumption were inversely associated with HSED, and low unhealthy food consumption was observed among high-disadvantage groups. No significant interaction between time period and HSED was observed on either scale. However, the post-regression estimates from the adjusted interaction model showed a significant association between convenience/fast food consumption and HSED in pre- and mid-pandemic periods. CONCLUSION: The study highlights the nuances of socioeconomic dynamics on the diet behaviors of children from low-income families during a natural disaster. CI - Copyright (c) 2024 Parthasarathy, Ranjit, Chuang, Markham, Pomeroy, Noyola, Ernest and Sharma. FAU - Parthasarathy, Nivedhitha AU - Parthasarathy N AD - Department of Health Promotion and Behavioral Sciences, University of Texas Health Science Center at Houston, School of Public Health, Houston, TX, United States. FAU - Ranjit, Nalini AU - Ranjit N AD - Michael and Susan Dell Center for Healthy Living, Department of Health Promotion and Behavioral Sciences, University of Texas Health Science Center at Houston, School of Public Health in Austin, Austin, TX, United States. FAU - Chuang, Ru-Jye AU - Chuang RJ AD - Center for Health Equity, Department of Epidemiology, University of Texas Health Science Center at Houston, School of Public Health, Houston, TX, United States. FAU - Markham, Christine AU - Markham C AD - Department of Health Promotion and Behavioral Sciences, University of Texas Health Science Center at Houston, School of Public Health, Houston, TX, United States. FAU - Pomeroy, Mike AU - Pomeroy M AD - Brighter Bites, Houston, TX, United States. FAU - Noyola, Jacqueline AU - Noyola J AD - Brighter Bites, Houston, TX, United States. FAU - Ernest, Deepali K AU - Ernest DK AD - Center for Health Equity, Department of Epidemiology, University of Texas Health Science Center at Houston, School of Public Health, Houston, TX, United States. FAU - Sharma, Shreela V AU - Sharma SV AD - Center for Health Equity, Department of Epidemiology, University of Texas Health Science Center at Houston, School of Public Health, Houston, TX, United States. LA - eng PT - Journal Article DEP - 20240925 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC11463149 OTO - NOTNLM OT - COVID-19 pandemic OT - children OT - diet OT - public health nutrition OT - unhealthy food COIS- Shreela Sharma serves on the board of directors of Brighter Bites 501c3 nonprofit organization. This is an unpaid board position. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/10/10 10:19 MHDA- 2024/10/10 10:20 PMCR- 2024/01/01 CRDT- 2024/10/10 04:54 PHST- 2024/07/22 00:00 [received] PHST- 2024/09/06 00:00 [accepted] PHST- 2024/10/10 10:20 [medline] PHST- 2024/10/10 10:19 [pubmed] PHST- 2024/10/10 04:54 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - 10.3389/fnut.2024.1468767 [doi] PST - epublish SO - Front Nutr. 2024 Sep 25;11:1468767. doi: 10.3389/fnut.2024.1468767. eCollection 2024. PMID- 39385737 OWN - NLM STAT- MEDLINE DCOM- 20241114 LR - 20260709 IS - 1759-9679 (Electronic) IS - 1759-9660 (Linking) VI - 16 IP - 44 DP - 2024 Nov 14 TI - Exhaled breath of children swimmers conveniently collected in Teflon bags and used for trihalomethane determination by SPME-GC-MS. PG - 7624-7632 LID - 10.1039/d4ay01499e [doi] AB - Trihalomethanes (THMs) are the most common disinfection by-products in swimming pools; however, they exhibit strong cytotoxicity and genotoxicity, posing health risks. Children are more vulnerable to swimming-related health risks than adults; therefore, a rapid and accurate assessment of internal THM exposure in children swimmers is important for health risk assessment. For internal exposure measurement, collecting exhaled breath samples is more convenient, non-invasive, and easier to perform than collecting blood and urine. Therefore, this study aimed to develop a rapid, accurate, and reproducible method for determining THMs in children swimmers' exhaled breath using solid-phase microextraction (SPME)-gas chromatography-mass spectrometry (GC-MS). The factors influencing the pretreatment procedure, including selecting SPME fibers, extraction temperature, and time, were systematically evaluated. Under the optimized conditions, the instrumental linearity range was 1-200 ng L(-1) with correlation coefficients >0.998. The limit of detection for this method was 0.3-0.5 ng L(-1). The recovery values ranged between 76.87 and 111.49%. Detecting THMs at three different calibration levels using this method had an intra-day precision of 1.31-5.07%, while the inter-day precision was 1.59-11.10% (n = 6). Additionally, the SPME-GC-MS method was used to detect the concentration of THMs in children swimmers' exhaled breath before and after swimming. Trichloromethane was the most abundant THM in the air around the pool and children's exhaled breath, and THM concentrations in the children swimmers' exhaled breath increased significantly after swimming. This study found no significant differences in the concentrations of THMs in the children swimmers' exhaled breath with different swimming durations or frequencies, which may be a result of the unrepresentative sample population and small sample size, and more in-depth and comprehensive studies are needed to verify this conclusion. FAU - Wang, Shunan AU - Wang S AD - The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi Medical Center, Nanjing Medical University, Wuxi, 214023, China. dingxinliang@njmu.edu.cn. AD - Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. FAU - Zhou, Run AU - Zhou R AD - The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi Medical Center, Nanjing Medical University, Wuxi, 214023, China. dingxinliang@njmu.edu.cn. FAU - Xu, Lingling AU - Xu L AD - The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi Medical Center, Nanjing Medical University, Wuxi, 214023, China. dingxinliang@njmu.edu.cn. FAU - Hao, Yamei AU - Hao Y AD - The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi Medical Center, Nanjing Medical University, Wuxi, 214023, China. dingxinliang@njmu.edu.cn. FAU - Zhang, Xi AU - Zhang X AD - The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi Medical Center, Nanjing Medical University, Wuxi, 214023, China. dingxinliang@njmu.edu.cn. FAU - Chen, Limei AU - Chen L AD - The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi Medical Center, Nanjing Medical University, Wuxi, 214023, China. dingxinliang@njmu.edu.cn. FAU - Zhu, Xun AU - Zhu X AD - The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi Medical Center, Nanjing Medical University, Wuxi, 214023, China. dingxinliang@njmu.edu.cn. FAU - Zhu, Pengfei AU - Zhu P AD - The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi Medical Center, Nanjing Medical University, Wuxi, 214023, China. dingxinliang@njmu.edu.cn. FAU - Ding, Xinliang AU - Ding X AUID- ORCID: 0000-0003-2950-4360 AD - The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi Medical Center, Nanjing Medical University, Wuxi, 214023, China. dingxinliang@njmu.edu.cn. AD - Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241114 PL - England TA - Anal Methods JT - Analytical methods : advancing methods and applications JID - 101519733 RN - 0 (Trihalomethanes) RN - 9002-84-0 (Polytetrafluoroethylene) SB - IM MH - Humans MH - *Solid Phase Microextraction/methods MH - *Trihalomethanes/analysis MH - *Breath Tests/methods MH - *Gas Chromatography-Mass Spectrometry/methods MH - Child MH - *Swimming/physiology MH - Male MH - Polytetrafluoroethylene/adverse effects MH - Limit of Detection MH - Female MH - Swimming Pools MH - Exhalation/physiology MH - Reproducibility of Results EDAT- 2024/10/10 06:23 MHDA- 2024/11/14 18:30 CRDT- 2024/10/10 04:53 PHST- 2024/11/14 18:30 [medline] PHST- 2024/10/10 06:23 [pubmed] PHST- 2024/10/10 04:53 [entrez] AID - 10.1039/d4ay01499e [doi] PST - epublish SO - Anal Methods. 2024 Nov 14;16(44):7624-7632. doi: 10.1039/d4ay01499e. PMID- 39384142 OWN - NLM STAT- MEDLINE DCOM- 20241204 LR - 20261008 IS - 1938-3207 (Electronic) IS - 0002-9165 (Print) IS - 0002-9165 (Linking) VI - 120 IP - 6 DP - 2024 Dec TI - A cross-sectional study of associations between the (13)C-sucrose breath test, the lactulose rhamnose assay, and growth in children at high risk of environmental enteropathy. PG - 1354-1363 LID - S0002-9165(24)00806-2 [pii] LID - 10.1016/j.ajcnut.2024.10.001 [doi] AB - BACKGROUND: Environmental enteropathy' (EE) is common among children who are highly exposed to enteric pathogens in low-resource settings. We optimized and validated a stable isotope-based breath test of intestinal sucrase activity ((13)C-SBT) as a noninvasive test of carbohydrate digestion and metabolism. OBJECTIVES: The primary objective of this study was to assess the relationship between the (13)C-SBT and the lactulose/rhamnose ratio (LR) and growth in children. Secondary objectives were to assess the relationship between the (13)C-SBT and additional biomarkers of EE. We also characterized the relationship between the (13)C-SBT and child sex and dietary diversity, as well as household socio-economic status and food security. METHODS: In this cross-sectional study, 12-to-15-mo-old children were recruited in Bangladesh, India, Kenya, and Peru. Children were assessed with a 4-h (13)C-SBT and a 90-min LR test. Plasma was collected to determine the citrulline and kynurenine/tryptophan ratio. Length and weight were measured, and other variables were assessed through questionnaires. For a subset of children, anthropometry was re-measured after 3 mo. Linear regression was used to examine associations corresponding to each objective. RESULTS: Three sites generated (13)C-SBT breath curves that enabled pooled analysis. Differences in (13)C-SBT breath curves, LR ratios, and other EE biomarkers were observed between sites. No associations were observed for (13)C-SBT summary measures and LR or child growth [e.g., the association between LR and cumulative percent dose recovered at 90 min: -0.39; 95% confidence interval (CI): -1.79, 0.70]. Length-for-age and weight-for-age were positively associated with the time to 50% of dose recovered (0.05; 95% CI: 0.01, 0.09, and 0.05; 95% CI: 0.02, 0.07, respectively), and dietary diversity was associated with time at which 50% of the dose recovered by 240 min is recovered and cumulative percent dose recovered at 90 min (-0.10; 95% CI: -0.18, -0.02 and 2.67; 95% CI: 0.47, 4.88, respectively). CONCLUSIONS: In children at risk of EE, there were no associations between the (13)C-SBT, LR, or other EE biomarkers encompassing different pathophysiological domains of EE. This trial was registered at clinicaltrials.gov as NCT04109352. CI - Copyright (c) 2024 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Shivakumar, Nirupama AU - Shivakumar N AD - Division of Nutrition, St. John's Research Institute, St. John's National Academy of Health Sciences (a Unit of CBCI Society for Medical Education), Bangalore, India. FAU - Huq, Sayeeda AU - Huq S AD - International Centre for Diarrhoeal Disease Research, Bangladesh. FAU - Paredes-Olortegui, Maribel AU - Paredes-Olortegui M AD - Investigaciones Biomedicas, Asociacion Benefica PRISMA, Iquitos, Peru. FAU - Konyole, Silvenus Ochieng AU - Konyole SO AD - Department of Nutritional Sciences, Masinde Muliro University of Science and Technology, Kakamega, Kenya. FAU - Devi, Sarita AU - Devi S AD - Division of Nutrition, St. John's Research Institute, St. John's National Academy of Health Sciences (a Unit of CBCI Society for Medical Education), Bangalore, India. FAU - Yazbeck, Roger AU - Yazbeck R AD - Flinders Centre for Innovation in Cancer, Flinders University, Adelaide, South Australia, Australia. FAU - Owino, Victor O AU - Owino VO AD - Division of Human Health, Nutritional and Health-Related Environmental Studies Section, International Atomic Energy Agency, Vienna, Austria. FAU - Brouwer, Andrew F AU - Brouwer AF AD - Department of Epidemiology, University of Michigan, Ann Arbor, MI, United States. FAU - Kosek, Margaret N AU - Kosek MN AD - Investigaciones Biomedicas, Asociacion Benefica PRISMA, Iquitos, Peru; Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, United States. FAU - Kelly, Paul AU - Kelly P AD - Tropical Gastroenterology and Nutrition group, University of Zambia School of Medicine, Lusaka, Zambia; Blizard Institute, Barts and The London School of Medicine, Queen Mary University of London, London, United Kingdom. FAU - Morrison, Douglas J AU - Morrison DJ AD - Scottish Universities Environmental Research Centre (SUERC), University of Glasgow, Scotland, United Kingdom. FAU - Lee, Gwenyth O AU - Lee GO AD - Rutgers Global Health Institute, Department of Biostatistics and Epidemiology, School of Public Health, Rutgers, the State University of New Jersey, New Brunswick, NJ, United States. Electronic address: gwenyth.lee@globalhealth.rutgers.edu. LA - eng SI - ClinicalTrials.gov/NCT04109352 GR - D43 TW010913/TW/FIC NIH HHS/United States GR - K01 AI145080/AI/NIAID NIH HHS/United States PT - Journal Article PT - Multicenter Study PT - Observational Study PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Validation Study DEP - 20241009 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 RN - 0 (Biomarkers) RN - 0 (Carbon Isotopes) RN - 4618-18-2 (Lactulose) RN - QN34XC755A (Rhamnose) RN - EC 3.2.1.48 (Sucrase) SB - IM MH - Female MH - Humans MH - Infant MH - Male MH - Biomarkers/blood MH - *Breath Tests/methods MH - *Carbon Isotopes MH - Cross-Sectional Studies MH - Intestinal Diseases MH - *Lactulose/metabolism MH - *Rhamnose/metabolism MH - Sucrase/metabolism PMC - PMC11619784 OTO - NOTNLM OT - environmental enteropathy OT - gut function OT - intestinal permeability OT - sucrose breath test COIS- Conflict of interest VOO is employed by the funding organization. All other authors report no conflicts of interest. EDAT- 2024/10/10 04:18 MHDA- 2024/12/05 05:31 PMCR- 2024/10/09 CRDT- 2024/10/09 19:19 PHST- 2024/07/02 00:00 [received] PHST- 2024/09/24 00:00 [revised] PHST- 2024/10/03 00:00 [accepted] PHST- 2024/12/05 05:31 [medline] PHST- 2024/10/10 04:18 [pubmed] PHST- 2024/10/09 19:19 [entrez] PHST- 2024/10/09 00:00 [pmc-release] AID - S0002-9165(24)00806-2 [pii] AID - 10.1016/j.ajcnut.2024.10.001 [doi] PST - ppublish SO - Am J Clin Nutr. 2024 Dec;120(6):1354-1363. doi: 10.1016/j.ajcnut.2024.10.001. Epub 2024 Oct 9. PMID- 39379499 OWN - NLM STAT- MEDLINE DCOM- 20241008 LR - 20260204 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Oct 8 TI - Cesarean birth is associated with lower motor and language development scores during early childhood: a longitudinal analysis of two cohorts. PG - 23438 LID - 10.1038/s41598-024-73914-7 [doi] LID - 23438 AB - With global C-section rates rising, understanding potential consequences is imperative. Previous studies suggested links between birth mode and psychological outcomes. This study evaluates the association of birth mode and neurodevelopment in young children across two prospective cohorts, using repeated psychometric assessments. Data from the ELEMENT (Early Life Exposures in Mexico to Environmental Toxicants) and PROGRESS (Programming Research in Obesity, Growth, and Environment and Social Stress) cohorts, comprising 7158 and 2202 observations of 1402 children aged 2 to 36 months, and 726 children aged 5 to 27 months, respectively, were analyzed. Exclusion criteria for the cohorts were maternal diseases such as preeclampsia, renal or heart disease, gestational diabetes, and epilepsy. Neurodevelopment was gauged via Bayley's Scales of Infant Development: 2nd edition for ELEMENT and 3rd edition for PROGRESS. Mixed-effects models longitudinally estimated associations between birth mode and neurodevelopment scores, adjusting for cofounders. In ELEMENT, psychomotor development composite scores were significantly affected by birth mode from ages 2 to 8 months; the largest estimate within this range was at 2 months (beta =-1.93; 95% CI: [-3.64, -0.22], reference: vaginal delivery). For PROGRESS, a negative association was found with motor development composite scores over all the studied age range (beta=-1.91; 95% CI: [-3.01, -0.81]). The association was stronger between ages 6 to 18 months, with the strongest estimate at 11 months (beta=-2.58; 95% CI: [-4.37, -0.74]). A negative impact of C-section on language scores in girls was estimated for the PROGRESS cohort (beta=-1.92; 95% CI: [-3.57, -0.27]), most marked in ages 22 to 25 months (largest beta at 24.5 months=-3.04; 95% CI: [-5.79, -0.30]). Children born by C-section showed lower motor and language development scores during specific age windows in the first three years of life. Further research is necessary to understand the complexities and implications of these findings. CI - (c) 2024. The Author(s). FAU - Fritz, Jimena AU - Fritz J AD - Department of Perinatal Health, National Institute of Public Health, Av. Universidad 655, CP 62100, Cuernavaca, Mexico. FAU - Lamadrid-Figueroa, Hector AU - Lamadrid-Figueroa H AD - Department of Perinatal Health, National Institute of Public Health, Av. Universidad 655, CP 62100, Cuernavaca, Mexico. hlamadrid@insp.mx. FAU - Munoz-Rocha, Teresa V AU - Munoz-Rocha TV AD - Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Mexico. FAU - Huerta-Garcia, Yanira AU - Huerta-Garcia Y AD - Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Mexico. FAU - Martinez-Silva, Gisela AU - Martinez-Silva G AD - Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Mexico. FAU - Trejo-Valdivia, Belem AU - Trejo-Valdivia B AD - Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Mexico. FAU - Martinez-Medina, Sandra AU - Martinez-Medina S AD - National Institute of Perinatology, Mexico City, Mexico. FAU - Hernandez-Chavez, Carmen AU - Hernandez-Chavez C AD - National Institute of Perinatology, Mexico City, Mexico. FAU - Osorio-Valencia, Erika AU - Osorio-Valencia E AD - National Institute of Perinatology, Mexico City, Mexico. FAU - Burris, Heather H AU - Burris HH AD - Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, USA. FAU - Peterson, Karen E AU - Peterson KE AD - University of Michigan-Ann Arbor, Ann Arbor, USA. FAU - Wright, Robert O AU - Wright RO AD - Icahn School of Medicine at Mount Sinai, New York, USA. FAU - Tellez-Rojo, Martha M AU - Tellez-Rojo MM AD - Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Mexico. LA - eng GR - R01 ES007821/ES/NIEHS NIH HHS/United States GR - R01 ES013744/ES/NIEHS NIH HHS/United States GR - R01 ES014930/ES/NIEHS NIH HHS/United States GR - UL1 TR004419/TR/NCATS NIH HHS/United States GR - P30 ES017885/ES/NIEHS NIH HHS/United States PT - Journal Article DEP - 20241008 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Child, Preschool MH - Infant MH - Male MH - *Cesarean Section MH - Longitudinal Studies MH - *Language Development MH - *Child Development MH - Pregnancy MH - Prospective Studies MH - Mexico PMC - PMC11461664 OTO - NOTNLM OT - Cesarean Section OT - Early Childhood OT - Longitudinal analysis OT - Neurodevelopmental outcomes COIS- The authors declare no competing interests. EDAT- 2024/10/09 00:23 MHDA- 2024/10/09 00:24 PMCR- 2024/10/08 CRDT- 2024/10/08 23:28 PHST- 2024/06/18 00:00 [received] PHST- 2024/09/23 00:00 [accepted] PHST- 2024/10/09 00:24 [medline] PHST- 2024/10/09 00:23 [pubmed] PHST- 2024/10/08 23:28 [entrez] PHST- 2024/10/08 00:00 [pmc-release] AID - 10.1038/s41598-024-73914-7 [pii] AID - 73914 [pii] AID - 10.1038/s41598-024-73914-7 [doi] PST - epublish SO - Sci Rep. 2024 Oct 8;14(1):23438. doi: 10.1038/s41598-024-73914-7. PMID- 39377665 OWN - NLM STAT- MEDLINE DCOM- 20241109 LR - 20241109 IS - 1941-2452 (Electronic) IS - 0884-5336 (Linking) VI - 39 IP - 6 DP - 2024 Dec TI - Patterns of use of malnutrition risk screening in pediatric populations: A survey of current practice among pediatric hospitals in North America. PG - 1500-1508 LID - 10.1002/ncp.11222 [doi] AB - Information on the use of validated malnutrition risk screening tools in pediatric facilities to guide malnutrition identification, diagnosis, and treatment is scarce. Therefore, a survey of pediatric healthcare facilities and practitioners to ascertain malnutrition risk screening practices in North America was conducted. A pediatric nutrition screening practices survey was developed and sent to members of the American Society for Parenteral and Enteral Nutrition, the Council for Pediatric Nutrition Professionals and the Academy of Nutrition and Dietetics Pediatric Nutrition Practice Group. Respondents represented 113 pediatric hospitals in the United States and six in Canada, of which 94 were inpatient and 59 were outpatient. Nutrition risk screening was completed in 90% inpatient settings, and 63% used a validated screening tool. Nurses performed most malnutrition risk screens in the inpatient setting. Nutrition risk screening was reported in 51% of outpatient settings, with a validated screening tool being used in 53%. Measured anthropometrics were used in 78% of inpatient settings, whereas 45% used verbally reported anthropometrics. Measured anthropometrics were used in 97% outpatient settings. Nutrition risk screening was completed in the electronic health record in 80% inpatient settings and 81% outpatient settings. Electronic health record positive screen generated an automatic referral in 80% of inpatient and 45% of outpatient settings. In this sample of pediatric healthcare organizations, the results demonstrate variation in pediatric malnutrition risk screening in North America. These inconsistencies justify the need to standardize pediatric malnutrition risk screening using validated pediatric tools and allocate resources to perform screening. CI - (c) 2024 American Society for Parenteral and Enteral Nutrition. FAU - Bellini, Sarah Gunnell AU - Bellini SG AUID- ORCID: 0000-0002-6755-6201 AD - Nutrition, Dietetics, and Food Science Department, Brigham Young University, Provo, Utah, USA. FAU - Becker, Patricia J AU - Becker PJ AUID- ORCID: 0000-0003-0538-419X AD - Private Practice Pediatric Neonatal Nutrition, Cincinnati, Ohio, USA. FAU - Abdelhadi, Ruba A AU - Abdelhadi RA AUID- ORCID: 0000-0002-5910-001X AD - Department of Pediatrics, University of Missouri Kansas City, Kansas City, Missouri, USA. AD - Children's Mercy Hospital, Kansas City, Missouri, USA. FAU - Karls, Catherine A AU - Karls CA AUID- ORCID: 0000-0002-4067-2835 AD - Children's Wisconsin, Milwaukee, Wisconsin, USA. FAU - Price, Alyssa L AU - Price AL AUID- ORCID: 0000-0003-2147-1322 AD - Dayton Children's Hospital, Dayton, Ohio, USA. FAU - Puthoff, Teresa D AU - Puthoff TD AUID- ORCID: 0000-0002-7657-4516 AD - Nationwide Children's Hospital, Columbus, Ohio, USA. FAU - Malone, Ainsley AU - Malone A AUID- ORCID: 0000-0001-8345-0303 AD - American Society for Parenteral and Enteral Nutrition, Silver Springs, Maryland, USA. LA - eng PT - Journal Article DEP - 20241008 PL - United States TA - Nutr Clin Pract JT - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JID - 8606733 SB - IM MH - Humans MH - *Hospitals, Pediatric/statistics & numerical data MH - Child MH - *Mass Screening/methods MH - *Nutrition Assessment MH - *Malnutrition/diagnosis/epidemiology MH - United States MH - Canada MH - Surveys and Questionnaires MH - Risk Assessment/methods MH - Anthropometry MH - Child Nutrition Disorders/diagnosis/epidemiology MH - Inpatients/statistics & numerical data MH - Electronic Health Records MH - North America MH - Child, Preschool MH - Practice Patterns, Physicians'/statistics & numerical data MH - Risk Factors MH - Infant OTO - NOTNLM OT - life cycle OT - nutrition OT - nutrition assessment OT - nutrition screening OT - nutrition support practice OT - outcomes research/quality OT - pediatrics OT - research and diseases OT - weight loss EDAT- 2024/10/08 12:25 MHDA- 2024/11/13 13:51 CRDT- 2024/10/08 09:43 PHST- 2024/09/16 00:00 [revised] PHST- 2024/03/27 00:00 [received] PHST- 2024/09/16 00:00 [accepted] PHST- 2024/11/13 13:51 [medline] PHST- 2024/10/08 12:25 [pubmed] PHST- 2024/10/08 09:43 [entrez] AID - 10.1002/ncp.11222 [doi] PST - ppublish SO - Nutr Clin Pract. 2024 Dec;39(6):1500-1508. doi: 10.1002/ncp.11222. Epub 2024 Oct 8. PMID- 39375584 OWN - NLM STAT- MEDLINE DCOM- 20241008 LR - 20260901 IS - 1471-2180 (Electronic) IS - 1471-2180 (Linking) VI - 24 IP - 1 DP - 2024 Oct 7 TI - Animal and plant protein intake association with mental health, tryptophan metabolites pathways, and gut microbiota in healthy women: a cross-sectional study. PG - 390 LID - 10.1186/s12866-024-03534-8 [doi] LID - 390 AB - Mental health is affected by tryptophane (TRP) metabolism regulation. Diet-influenced gut microbiome regulates TRP metabolism. Thus, the present study aimed to explore the relationship between type of dietary protein intake, gut microbiota, TRP metabolites homeostasis, and mental well-being in healthy women. 91 healthy females aged 18-50 were recruited based on the study protocol. Validate and reliable questionnaires assessed dietary intake and mental health. Biochemical tests and gut microbiota composition were analyzed following the manufacturer's instructions for each enzyme-linked immune sorbent assay (ELISA) kit and Real-time quantitative polymerase chain reaction (qPCR) methods respectively. Regression methods were used to estimate the considered associations. The results show that in the fully adjusted model, plant protein consumption was partially inversely associated with depression risk (OR = 0.27; 95% CI: 0.06, 1.09; P = 0.06). Higher dietary animal protein intake was marginally associated with psychological distress (OR = 2.59; 95% CI: 0.91, 7.34; P = 0.07). KYN to serotonin ratio was inversely associated with animal protein consumption (ss = 1.10; 95% CI: -0.13, 2.33; P = 0.07). Firmicutes/Bacteriodetes ratio (beta = -1.27 x 103, SE = 5.99 x 102, P = 0.03) was lower in the top tertile of plant protein. A partially negative correlation was found between dietary animal protein and Prevotella abundance (beta = -9.20 x 1018, SE = 5.04 x 1018, P = 0.06). Overall, significant inverse associations were found between a diet high in plant protein with mental disorders, KYN levels, and Firmicutes to Bacteroidetes ratio while adhering to higher animal protein could predispose women to psychological stress. CI - (c) 2024. The Author(s). FAU - Soveid, Neda AU - Soveid N AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O Box 6446, Tehran, 14155, Iran. FAU - Barkhidarian, Bahareh AU - Barkhidarian B AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O Box 6446, Tehran, 14155, Iran. FAU - Samadi, Mahsa AU - Samadi M AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O Box 6446, Tehran, 14155, Iran. FAU - Hatami, Mahsa AU - Hatami M AD - Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. FAU - Gholami, Fatemeh AU - Gholami F AD - Food Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. FAU - Yekaninejad, Mir Saeid AU - Yekaninejad MS AD - Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Science, Tehran, Iran. FAU - Saedisomeolia, Ahmad AU - Saedisomeolia A AD - College of Health Sciences, Education Centre of Australia, Parramatta, NSW, 2153, Australia. AD - School of Human Nutrition, McGill University, Montreal, Canada. FAU - Karbasian, Maryam AU - Karbasian M AD - Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, P.O Box 6446, Tehran, 14155, Iran. FAU - Siadat, Seyed Davar AU - Siadat SD AD - Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, P.O Box 6446, Tehran, 14155, Iran. d.siadat@gmail.com. FAU - Mirzaei, Khadijeh AU - Mirzaei K AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O Box 6446, Tehran, 14155, Iran. mirzaei_kh@tums.ac.ir. AD - Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran. mirzaei_kh@tums.ac.ir. LA - eng PT - Journal Article DEP - 20241007 PL - England TA - BMC Microbiol JT - BMC microbiology JID - 100966981 RN - 8DUH1N11BX (Tryptophan) RN - 0 (Plant Proteins) RN - 0 (Animal Proteins, Dietary) SB - IM MH - Humans MH - Female MH - Adult MH - *Gastrointestinal Microbiome MH - *Tryptophan/metabolism MH - Cross-Sectional Studies MH - Middle Aged MH - Young Adult MH - *Mental Health MH - Adolescent MH - Depression/microbiology/metabolism MH - Diet MH - Plant Proteins/metabolism MH - Animal Proteins, Dietary MH - Bacteria/classification/genetics/isolation & purification/metabolism MH - Animals MH - Healthy Volunteers PMC - PMC11457455 OTO - NOTNLM OT - Anxiety OT - Depression OT - Gut microbiota OT - Mental health OT - Protein source OT - Stress COIS- The authors declare no competing interests. EDAT- 2024/10/08 00:23 MHDA- 2024/10/08 10:18 PMCR- 2024/10/07 CRDT- 2024/10/07 23:39 PHST- 2024/05/25 00:00 [received] PHST- 2024/09/18 00:00 [accepted] PHST- 2024/10/08 10:18 [medline] PHST- 2024/10/08 00:23 [pubmed] PHST- 2024/10/07 23:39 [entrez] PHST- 2024/10/07 00:00 [pmc-release] AID - 10.1186/s12866-024-03534-8 [pii] AID - 3534 [pii] AID - 10.1186/s12866-024-03534-8 [doi] PST - epublish SO - BMC Microbiol. 2024 Oct 7;24(1):390. doi: 10.1186/s12866-024-03534-8. PMID- 39370180 OWN - NLM STAT- MEDLINE DCOM- 20241006 LR - 20260127 IS - 0019-5707 (Print) IS - 0019-5707 (Linking) VI - 71 Suppl 2 DP - 2024 TI - Nutritional status and adherence to anti-tubercular treatment among tuberculosis patients in a community development block of Eastern India. PG - S178-S183 LID - S0019-5707(23)00062-8 [pii] LID - 10.1016/j.ijtb.2023.04.005 [doi] AB - BACKGROUND: Undernutrition is a risk factor for developing tuberculosis (TB) and adherence to treatment leads to successful treatment outcomes. OBJECTIVES: To assess the nutritional status and adherence to treatment among tuberculosis patients in Bhatar Community Development Block of Purba Bardhaman district, West Bengal, India. MATERIAL & METHODS: A cross sectional descriptive study was conducted among all the 82 tuberculosis patients registered between April to June, 2021, under NTEP in Bhatar tuberculosis unit (TU), who completed at least 1 month of therapy. Nutritional status was assessed based on BMI and adherence to treatment was evaluated by interviewing with a validated version of Morisky Medication Adherence Scale (MMAS-8-Item). Data was analysed using SPSS v23. RESULTS: Among the 82 subjects, 51 (62.2%) were found to be underweight and overall high level of adherence to treatment was found among 51 (62.2%) of study subjects. Subjects aged >45 years (AOR 3.686, 95% CI: 1.147-11.842) and having extra-pulmonary Tuberculosis (AOR 8.539, 95% CI: 1.305-55.871) were significantly associated as being adherent to treatment. CONCLUSION: Health education, awareness and more vigilant monitoring is still needed so that TB patients can be cured successfully. Special attention needs to be given on the nutritional status of the TB patients. CI - Copyright (c) 2023 Tuberculosis Association of India. Published by Elsevier B.V. All rights reserved. FAU - Islam, Shahinoor AU - Islam S AD - Junior Resident, Department of Community Medicine, Burdwan Medical College, Purba Bardhaman, West Bengal, India. FAU - Das, Sulagna AU - Das S AD - Assistant Professor, Department of Community Medicine, Burdwan Medical College, Purba Bardhaman, West Bengal, India. Electronic address: drsulagnadas21@gmail.com. FAU - Das, Dilip Kumar AU - Das DK AD - Professor and Head, Department of Community Medicine, Burdwan Medical College, Purba Bardhaman, West Bengal, India. LA - eng PT - Journal Article DEP - 20230418 PL - India TA - Indian J Tuberc JT - The Indian journal of tuberculosis JID - 0373027 RN - 0 (Antitubercular Agents) SB - IM MH - Humans MH - India/epidemiology MH - *Nutritional Status MH - Male MH - Female MH - *Antitubercular Agents/therapeutic use MH - Cross-Sectional Studies MH - Adult MH - Middle Aged MH - *Tuberculosis/drug therapy/epidemiology MH - Thinness/epidemiology MH - Tuberculosis, Pulmonary/drug therapy/epidemiology MH - Young Adult MH - Malnutrition/epidemiology MH - Body Mass Index MH - Adolescent MH - *Drug Monitoring OTO - NOTNLM OT - Adherence OT - Morisky medication adherence scale OT - Nutritional status OT - Tuberculosis EDAT- 2024/10/07 00:35 MHDA- 2024/10/07 00:36 CRDT- 2024/10/06 20:56 PHST- 2022/11/12 00:00 [received] PHST- 2023/03/30 00:00 [revised] PHST- 2023/04/05 00:00 [accepted] PHST- 2024/10/07 00:36 [medline] PHST- 2024/10/07 00:35 [pubmed] PHST- 2024/10/06 20:56 [entrez] AID - S0019-5707(23)00062-8 [pii] AID - 10.1016/j.ijtb.2023.04.005 [doi] PST - ppublish SO - Indian J Tuberc. 2024;71 Suppl 2:S178-S183. doi: 10.1016/j.ijtb.2023.04.005. Epub 2023 Apr 18. PMID- 39368599 OWN - NLM STAT- MEDLINE DCOM- 20250122 LR - 20250122 IS - 1096-0953 (Electronic) IS - 0013-9351 (Linking) VI - 263 IP - Pt 2 DP - 2024 Dec 15 TI - Anti-inflammatory diet mitigate cardiovascular risks due to particulate matter exposure in women during pregnancy: A perspective cohort study from China. PG - 120104 LID - S0013-9351(24)02011-5 [pii] LID - 10.1016/j.envres.2024.120104 [doi] AB - BACKGROUND: Particulate matter (PM) exposure during pregnancy may increase cardiovascular risk (CVR). However, the specific time windows of exposure contributing to this association and the potential biological mechanisms underlying it remain unclear. OBJECTIVE: To determine the sensitive time window for CVR related to PM exposure. We investigated whether levels of inflammatory biomarkers mediate the relationship between PM exposure and CVR, and examined the potential impact of an anti-inflammatory diet on this association. METHODS: From 2015 to 2021, 9294 pregnant women from three Hefei hospitals were included. We used a 1 x 1 km satellite dataset to assess PM(1), PM(2.5), and PM(10) exposure. High-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) were measured as inflammatory biomarkers. The empirical dietary inflammatory pattern (EDIP) score, based on a validated food frequency questionnaire. The CVR score was calculated using five clinical metrics based on American Heart Association criteria. RESULTS: We found a significant association between PM exposure and increased CVR score, especially during the 2nd to 8th weeks of the first trimester. For every increase of 10-mug/m(3) of PM(1), PM(2.5), and PM(10), there was an associated increase in CVR of 0.51 (95%CI: 0.21, 082), 0.25 (95% CI: 0.11 to 0.39), and 0.29 (95% CI: 0.09 to 0.37), respectively. Mediation analysis revealed that the proportion of the association between PM(1), PM(2.5), and PM(10) exposure and CVR mediated by inflammatory biomarkers was 24.3%, 22.4%, and 20.1%, respectively. Stratified analyses showed no positive correlation between PM exposure and CVR in the anti-inflammatory diet (low EDIP) group. The beta coefficients were 0.52 for PM(1) (95% CI: -0.06 to 1.11), 0.31 for PM(2.5) (95% CI: -0.04 to 0.79), and 0.25 for PM(10) (95% CI: -0.03 to 0.54). CONCLUSIONS: PM exposure, particularly during weeks 2-8 of pregnancy, correlates with CVR, partly mediated by levels of inflammatory biomarkers. An anti-inflammatory diet mitigates CVR associated with PM exposure. CI - Copyright (c) 2024 Elsevier Inc. All rights reserved. FAU - Zu, Ping AU - Zu P AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China; MOE Key Laboratory of Population Health Across Life Cycle, Hefei, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, China; Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, China. FAU - Zhang, Lei AU - Zhang L AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China; MOE Key Laboratory of Population Health Across Life Cycle, Hefei, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, China; Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, China. FAU - Zhang, Kun AU - Zhang K AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China; MOE Key Laboratory of Population Health Across Life Cycle, Hefei, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, China; Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, China. FAU - He, Liping AU - He L AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China; MOE Key Laboratory of Population Health Across Life Cycle, Hefei, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, China; Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, China. FAU - Fan, Yujie AU - Fan Y AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China; MOE Key Laboratory of Population Health Across Life Cycle, Hefei, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, China; Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, China. FAU - Zhou, Chenxi AU - Zhou C AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China; MOE Key Laboratory of Population Health Across Life Cycle, Hefei, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, China; Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, China. FAU - Chen, Yunlong AU - Chen Y AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China; MOE Key Laboratory of Population Health Across Life Cycle, Hefei, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, China; Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, China. FAU - Zhang, Ying AU - Zhang Y AD - Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. FAU - Tao, Ruixue AU - Tao R AD - Department of Gynecology and Obstetrics, Hefei First People's Hospital, Hefei, China. FAU - Chen, Xianxia AU - Chen X AD - Department of Obstetrics and Gynecology, Anhui Women and Child Health Care Hospital, Hefei, 230001, China. FAU - Zhu, Peng AU - Zhu P AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China; MOE Key Laboratory of Population Health Across Life Cycle, Hefei, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, China; Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, China. Electronic address: pengzhu@ahmu.edu.cn. LA - eng PT - Journal Article DEP - 20241003 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - 0 (Anti-Inflammatory Agents) RN - 0 (Particulate Matter) RN - 0 (Inflammation Mediators) RN - 0 (Biomarkers) SB - IM MH - *Anti-Inflammatory Agents/pharmacology MH - *Diet MH - *Heart Disease Risk Factors MH - *Particulate Matter/toxicity MH - Humans MH - Female MH - Pregnancy MH - Cohort Studies MH - China MH - *Maternal Exposure MH - Adolescent MH - Young Adult MH - Adult MH - Inflammation Mediators/blood MH - Biomarkers/blood OTO - NOTNLM OT - Anti-inflammatory diet OT - Cardiovascular risk OT - Inflammatory biomarkers OT - Particulate matter OT - Prospective cohort study COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/10/06 13:43 MHDA- 2024/12/01 15:22 CRDT- 2024/10/05 19:13 PHST- 2024/07/29 00:00 [received] PHST- 2024/09/15 00:00 [revised] PHST- 2024/10/02 00:00 [accepted] PHST- 2024/12/01 15:22 [medline] PHST- 2024/10/06 13:43 [pubmed] PHST- 2024/10/05 19:13 [entrez] AID - S0013-9351(24)02011-5 [pii] AID - 10.1016/j.envres.2024.120104 [doi] PST - ppublish SO - Environ Res. 2024 Dec 15;263(Pt 2):120104. doi: 10.1016/j.envres.2024.120104. Epub 2024 Oct 3. PMID- 39368540 OWN - NLM STAT- MEDLINE DCOM- 20241111 LR - 20241113 IS - 1873-6351 (Electronic) IS - 0278-6915 (Linking) VI - 193 DP - 2024 Nov TI - Dietary exposure to metals/metalloids and persistent organic pollutants in Spanish preschool and primary school children. PG - 115030 LID - S0278-6915(24)00596-9 [pii] LID - 10.1016/j.fct.2024.115030 [doi] AB - Diet is a primary source of pollutant exposure. Given children's vulnerability to their effects, this study assessed dietary intake of metals/metalloids and different persistent organic pollutants in children in Tarragona (Spain), compared it with the health-based guideline values (HBGV), and identified the main dietary sources. The analysis included 533 preschoolers and 443 primary school children from the EPINED and ECLIPSES studies. Dietary intake of cadmium (Cd), methylmercury (MeHg), lead (Pb), inorganic arsenic (inAs), polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), dioxin-like polychlorinated biphenyls (DL-PCBs), and non-dioxin-like polychlorinated biphenyls (NDL-PCBs) was estimated using validated food frequency questionnaires and a database from the Catalan Agency for Food Safety. Preschoolers and primary school children exceeded the relevant reference value for InAs and DL-PCBs. Only preschoolers exceeded the limit for MeHg and PCDD/Fs. Cd, Pb, and NDL-PCBs intakes did not exceed the limits in either age group. Salted cereals/potatoes were the main source of InAs; fish for MeHg and DL-PCBs; and milk/yogurt for PCDD/Fs, followed by white fish in preschoolers and fatty fish in primary school children. The findings highlight that dietary exposure to some pollutants poses a significant risk to these children, emphasizing the need for public health policies to reduce pollutants in their diets. CI - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Becerra-Tomas, Nerea AU - Becerra-Tomas N AD - Universitat Rovira i Virgili, Departament de Ciencies Mediques Basiques, Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Reus, Spain; Institut D'Investigacio Sanitaria Pere Virgili (IISPV), 43005, Tarragona, Spain. Electronic address: nerea.becerra@urv.cat. FAU - Arija, Victoria AU - Arija V AD - Universitat Rovira i Virgili, Departament de Ciencies Mediques Basiques, Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Reus, Spain; Institut D'Investigacio Sanitaria Pere Virgili (IISPV), 43005, Tarragona, Spain; Institut Catala de La Salut (ICS), Collaborative Group on Lifestyles, Nutrition, and Tobacco (CENIT), Institut D'Investigacio en Atencio Primaria IDIAP Jordi Gol, Reus, Spain; Institut D'Investigacio en Atencio Primaria IDIAP Jordi Gol, Institut Catala de La Salut (ICS), Barcelona, Spain; University Research Institute on Sustainablility, Climate Change and Energy Transition (IU-RESCAT), Universitat Rovira i Virgili, 43003, Tarragona, Spain. Electronic address: victoria.arija@urv.cat. FAU - Jardi, Cristina AU - Jardi C AD - Universitat Rovira i Virgili, Departament de Ciencies Mediques Basiques, Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Reus, Spain; Institut D'Investigacio Sanitaria Pere Virgili (IISPV), 43005, Tarragona, Spain. Electronic address: cristina.jardi@urv.cat. FAU - Riggioni-Saborio, Lucia AU - Riggioni-Saborio L AD - Universitat Rovira i Virgili, Departament de Ciencies Mediques Basiques, Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Reus, Spain. Electronic address: lurisa1495@gmail.com. FAU - Bedmar, Cristina AU - Bedmar C AD - Universitat Rovira i Virgili, Departament de Ciencies Mediques Basiques, Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Reus, Spain; Institut D'Investigacio Sanitaria Pere Virgili (IISPV), 43005, Tarragona, Spain. Electronic address: cristina.bedmar@urv.cat. FAU - Canals-Sans, Josefa AU - Canals-Sans J AD - Institut D'Investigacio Sanitaria Pere Virgili (IISPV), 43005, Tarragona, Spain; University Research Institute on Sustainablility, Climate Change and Energy Transition (IU-RESCAT), Universitat Rovira i Virgili, 43003, Tarragona, Spain; Universitat Rovira i Virgili, Department of Psychology, Nutrition and Mental Health (NUTRISAM) Research Group, Research Center for Behavioral Assessment (CRAMC), Tarragona, Spain. Electronic address: josefa.canals@urv.cat. LA - eng PT - Journal Article DEP - 20241003 PL - England TA - Food Chem Toxicol JT - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JID - 8207483 RN - 0 (Metals) RN - 0 (Persistent Organic Pollutants) RN - 0 (Metalloids) RN - DFC2HB4I0K (Polychlorinated Biphenyls) SB - IM MH - Humans MH - Child MH - Spain MH - Child, Preschool MH - Male MH - Female MH - *Dietary Exposure MH - *Metals/analysis/toxicity MH - Persistent Organic Pollutants MH - Metalloids/analysis/toxicity MH - Food Contamination/analysis MH - Polychlorinated Biphenyls/analysis/toxicity MH - Diet MH - Schools OTO - NOTNLM OT - Children OT - Metalloids OT - Metals OT - Persistent organic pollutants COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/10/06 13:43 MHDA- 2024/11/13 13:57 CRDT- 2024/10/05 19:13 PHST- 2024/08/05 00:00 [received] PHST- 2024/10/01 00:00 [revised] PHST- 2024/10/02 00:00 [accepted] PHST- 2024/11/13 13:57 [medline] PHST- 2024/10/06 13:43 [pubmed] PHST- 2024/10/05 19:13 [entrez] AID - S0278-6915(24)00596-9 [pii] AID - 10.1016/j.fct.2024.115030 [doi] PST - ppublish SO - Food Chem Toxicol. 2024 Nov;193:115030. doi: 10.1016/j.fct.2024.115030. Epub 2024 Oct 3. PMID- 39366809 OWN - NLM STAT- MEDLINE DCOM- 20250424 LR - 20260618 IS - 1590-3729 (Electronic) IS - 0939-4753 (Linking) VI - 35 IP - 2 DP - 2025 Feb TI - Longitudinal trends of body composition in Anorexia Nervosa: Cardiac functioning impacts the restoration of fat-free mass at three-months follow-up. PG - 103728 LID - S0939-4753(24)00331-4 [pii] LID - 10.1016/j.numecd.2024.08.021 [doi] AB - BACKGROUND AND AIMS: Predictors of outcomes are needed in order to improve the clinical management of patients with Anorexia Nervosa (AN). The present study evaluated whether cardiac dysfunction might be associated with different longitudinal outcomes of AN. METHODS AND RESULTS: A sample of 35 patients with AN (11 restricting, 24 binge-purging- age range 16-28 years old) and 42 healthy controls (18-29 years old) were evaluated in terms of psychometric variables, Body Mass Index (BMI), body composition (by bioimpedance analysis, namely: Fat-Free Mass - FFM, Fat Mass - FM, Body Cell Mass - BCM, Phase Angle - PhA) and cardiac functioning (left ventricular ejection fraction - LVEF; global longitudinal strain - LVGLS). FM was significantly and negatively associated with eating psychopathology (weight and shape concerns, b -0.523, p 0.029; and shape concerns b -0.578, p0.015), while cardiac dysfunction (LVGLS > -18%) was positively associated with dietary restraints (b 1.253, p 0.043). LVEF, in turn, was positively associated with BCM (b 0.721, p 0.008) and FFM (b 0.779, p 0.039). Cardiac dysfunction negatively impacted the effect of nutritional rehabilitation, as those patients reporting reduced LVGLS showed lower FFM (b -4.410, p 0.011), FM (b -1.495, p 0.003) and BCM (b -2.205, p 0.015) at follow-up after three months. CONCLUSION: These preliminary results showed that cardiac functioning might represent an early predictor of cachexia and chronicity, while body composition seems to be a more accurate measure for evaluating the recovery process of patients with AN. CI - Copyright (c) 2024 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Tarchi, Livio AU - Tarchi L AD - Psychiatry Unit, Department of Health Sciences, University of Florence, AOU Florence, 50134, Italy. FAU - Cassioli, Emanuele AU - Cassioli E AD - Psychiatry Unit, Department of Health Sciences, University of Florence, AOU Florence, 50134, Italy. FAU - Rossi, Eleonora AU - Rossi E AD - Psychiatry Unit, Department of Health Sciences, University of Florence, AOU Florence, 50134, Italy. FAU - Faldi, Marco AU - Faldi M AD - Psychiatry Unit, Department of Health Sciences, University of Florence, AOU Florence, 50134, Italy. FAU - D'Areglia, Eleonora AU - D'Areglia E AD - Dietetics Unit, Careggi University Hospital, Florence, 50134, Italy. FAU - Maiolini, Gaia AU - Maiolini G AD - Dietetics Unit, Careggi University Hospital, Florence, 50134, Italy. FAU - Nannoni, Anita AU - Nannoni A AD - Dietetics Unit, Careggi University Hospital, Florence, 50134, Italy. FAU - Scheggi, Valentina AU - Scheggi V AD - Division of Cardiovascular and Perioperative Medicine, Careggi University Hospital, Florence, 50134, Italy. FAU - Alterini, Brunetto AU - Alterini B AD - Division of Cardiovascular and Perioperative Medicine, Careggi University Hospital, Florence, 50134, Italy. FAU - Ricca, Valdo AU - Ricca V AD - Psychiatry Unit, Department of Health Sciences, University of Florence, AOU Florence, 50134, Italy. FAU - Castellini, Giovanni AU - Castellini G AD - Psychiatry Unit, Department of Health Sciences, University of Florence, AOU Florence, 50134, Italy. Electronic address: giovanni.castellini@unifi.it. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240905 PL - Netherlands TA - Nutr Metab Cardiovasc Dis JT - Nutrition, metabolism, and cardiovascular diseases : NMCD JID - 9111474 SB - IM MH - Humans MH - *Anorexia Nervosa/physiopathology/diagnosis/therapy/complications/psychology MH - Adult MH - Female MH - Adolescent MH - *Body Composition MH - Young Adult MH - *Ventricular Function, Left MH - Time Factors MH - *Stroke Volume MH - Case-Control Studies MH - Recovery of Function MH - Male MH - Longitudinal Studies MH - Risk Factors MH - *Adiposity MH - *Ventricular Dysfunction, Left/physiopathology/etiology/diagnosis MH - Treatment Outcome OTO - NOTNLM OT - Bioimpedance analysis OT - Clinical staging OT - Echocardiography OT - Feeding and eating disturbances OT - Mental health COIS- Declaration of competing interest The authors report there are no competing interests to declare. EDAT- 2024/10/06 07:18 MHDA- 2025/02/10 00:19 CRDT- 2024/10/04 21:54 PHST- 2024/03/24 00:00 [received] PHST- 2024/07/28 00:00 [revised] PHST- 2024/08/28 00:00 [accepted] PHST- 2025/02/10 00:19 [medline] PHST- 2024/10/06 07:18 [pubmed] PHST- 2024/10/04 21:54 [entrez] AID - S0939-4753(24)00331-4 [pii] AID - 10.1016/j.numecd.2024.08.021 [doi] PST - ppublish SO - Nutr Metab Cardiovasc Dis. 2025 Feb;35(2):103728. doi: 10.1016/j.numecd.2024.08.021. Epub 2024 Sep 5. PMID- 39367334 OWN - NLM STAT- MEDLINE DCOM- 20241005 LR - 20241007 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 24 IP - 1 DP - 2024 Oct 4 TI - Iron status, anemia, and birth outcomes among pregnant women in urban Bloemfontein, South Africa: the NuEMI study. PG - 650 LID - 10.1186/s12884-024-06845-w [doi] LID - 650 AB - BACKGROUND: Despite routine iron supplementation for pregnant women in South Africa, anaemia and iron deficiency (ID) in pregnancy remain a public health concern. OBJECTIVE: To determine the associations between iron status and birth outcomes of pregnant women attending antenatal clinic at a regional hospital in Bloemfontein. METHODS: In this cross-sectional study of 427 pregnant women, blood was taken to analyze biomarkers of anaemia (haemoglobin), iron status (ferritin and soluble transferrin receptor) and inflammation (C-reactive protein and alpha-1-acid glycoprotein). A questionnaire was used to collect information about birth outcomes (birth weight and gestational age at birth), HIV exposure, sociodemographics, iron supplement intake, and maternal dietary iron intake using a validated quantified food frequency questionnaire. RESULTS: The median (Q(1), Q(3)) weeks of gestation of participants was 32 (26, 36) at enrolment. Anaemia, iron deficiency (ID), ID anaemia (IDA) and ID erythropoiesis (IDE) were present in 42%, 31%, 19% and 9.8% of participants, respectively. Median (Q(1), Q(3)) dietary and supplemental iron intake during pregnancy was 16.8 (12.7, 20.5) mg/d and 65 (65, 65) mg/d, respectively. The median (max-min) total iron intake (diet and supplements) was 81 (8.8-101.8) mg/d, with 88% of participants having a daily intake above the tolerable upper intake level of 45 mg/d. No significant associations of anaemia and iron status with low birth weight and prematurity were observed. However, infants born to participants in the third hemoglobin (Hb) quartile (Hb > 11.3-12.2 g/dL) had a shorter gestation by 1 week than those in the fourth Hb quartile (Hb > 12.2 g/dL) (p = 0.009). Compared to pregnant women without HIV, women with HIV had increased odds of being anaemic (OR:2.14, 95%CI: 1.41, 3.247), having ID (OR:2.19, 95%CI: 1.42, 3.37), IDA (OR:2.23, 95%CI: 1.36, 3.67), IDE (OR:2.22, 95%CI: 1.16, 4.22) and delivering prematurely (OR:2.39, 95%CI: 1.01, 5.64). CONCLUSION: In conclusion, anaemia, ID, and IDA were prevalent in this sample of pregnant women, despite the reported intake of prescribed iron supplements, with HIV-infected participants more likely to be iron deficient and anaemic. Research focusing on the best formulation and dosage of iron supplementation to enhance iron absorption and status, and compliance to supplementation is recommended, especially for those living with HIV infection. CI - (c) 2024. The Author(s). FAU - Carboo, Janet Adede AU - Carboo JA AD - Department of Nutrition and Dietetics, School of Health and Rehabilitation Sciences, Faculty of Health Sciences, University of the Free State, P.O. Box 339, Bloemfontein, 9300, South Africa. carboojane@gmail.com. FAU - Ngounda, Jennifer AU - Ngounda J AD - Department of Nutrition and Dietetics, School of Health and Rehabilitation Sciences, Faculty of Health Sciences, University of the Free State, P.O. Box 339, Bloemfontein, 9300, South Africa. FAU - Baumgartner, Jeannine AU - Baumgartner J AD - Department of Nutritional Sciences, King's College, Waterloo Campus, 57 Waterloo Road, London, SE1 8WA, UK. FAU - Robb, Liska AU - Robb L AD - Department of Nutrition and Dietetics, School of Health and Rehabilitation Sciences, Faculty of Health Sciences, University of the Free State, P.O. Box 339, Bloemfontein, 9300, South Africa. FAU - Jordaan, Marizeth AU - Jordaan M AD - Department of Nutrition and Dietetics, School of Health and Rehabilitation Sciences, Faculty of Health Sciences, University of the Free State, P.O. Box 339, Bloemfontein, 9300, South Africa. FAU - Walsh, Corinna May AU - Walsh CM AD - Department of Nutrition and Dietetics, School of Health and Rehabilitation Sciences, Faculty of Health Sciences, University of the Free State, P.O. Box 339, Bloemfontein, 9300, South Africa. LA - eng PT - Journal Article DEP - 20241004 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 RN - 9007-73-2 (Ferritins) RN - 0 (Hemoglobins) RN - 9007-41-4 (C-Reactive Protein) RN - 0 (Orosomucoid) RN - 0 (Biomarkers) RN - E1UOL152H7 (Iron) RN - 0 (Receptors, Transferrin) RN - 0 (Iron, Dietary) SB - IM MH - Humans MH - Female MH - Pregnancy MH - South Africa/epidemiology MH - Adult MH - Cross-Sectional Studies MH - *Anemia, Iron-Deficiency/epidemiology/blood MH - *Ferritins/blood MH - *Dietary Supplements MH - *Hemoglobins/analysis MH - Young Adult MH - C-Reactive Protein/analysis MH - Infant, Newborn MH - Orosomucoid/analysis MH - Gestational Age MH - Pregnancy Outcome/epidemiology MH - Biomarkers/blood MH - Pregnancy Complications, Hematologic/epidemiology/blood MH - Iron/blood/administration & dosage MH - Receptors, Transferrin/blood MH - Birth Weight MH - Iron, Dietary/administration & dosage MH - HIV Infections/blood/epidemiology MH - Urban Population/statistics & numerical data MH - Premature Birth/epidemiology/blood PMC - PMC11452952 OTO - NOTNLM OT - Anaemia OT - Birth outcomes OT - Iron deficiency OT - Iron deficiency anaemia OT - Iron deficiency erythropoiesis OT - Iron supplementation OT - Pregnancy COIS- The authors declare no competing interests. EDAT- 2024/10/05 11:44 MHDA- 2024/10/05 11:45 PMCR- 2024/10/04 CRDT- 2024/10/04 23:39 PHST- 2024/03/19 00:00 [received] PHST- 2024/09/20 00:00 [accepted] PHST- 2024/10/05 11:45 [medline] PHST- 2024/10/05 11:44 [pubmed] PHST- 2024/10/04 23:39 [entrez] PHST- 2024/10/04 00:00 [pmc-release] AID - 10.1186/s12884-024-06845-w [pii] AID - 6845 [pii] AID - 10.1186/s12884-024-06845-w [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2024 Oct 4;24(1):650. doi: 10.1186/s12884-024-06845-w. PMID- 39367114 OWN - NLM STAT- MEDLINE DCOM- 20251103 LR - 20261010 IS - 1432-1971 (Electronic) IS - 0172-0643 (Linking) VI - 46 IP - 8 DP - 2025 Dec TI - Identifying Frailty and Its Risk Factors in Pediatric Patients with Fontan Physiology. PG - 2339-2347 LID - 10.1007/s00246-024-03661-z [doi] AB - Frailty is a clinical syndrome common in adults with chronic disease with resultant vulnerability to adverse health outcomes. Little is known about frailty in pediatric patients, including those with single-ventricle heart disease. This study aimed to examine the prevalence of frailty and its associated risk factors in patients with Fontan circulation. A single-center, prospective cohort study assessed frailty in patients (10-21 years old) after Fontan palliation. Slowness, weakness, exhaustion, shrinkage, and diminished physical activity were evaluated and scored using a modified Fried frailty assessment comprised of validated pediatric tests. Providers estimated subjects' degree of frailty. Patient-reported quality of life (QOL) was assessed. Of 54 participants (median age 15.3 years, 61% male), 18 (33%) were identified as frail, while 26 (48%) were pre-frail. Patients frequently exhibited frailty in the domains of slowness (93%), weakness (41%), and diminished physical activity (39%). There was poor correlation between frailty scores and provider estimates of frailty (Kappa = 0.11). Frail subjects had lower PedsQL physical functioning scores (mean 62.8 +/- SD 18.5 in Frail vs. 75.7 +/- 16.0 in No/pre-Frail; p = 0.01). Factors associated with frailty included protein-losing enteropathy (p = 0.03) and at least one hospitalization in the last year (p = 0.047). One-third of pediatric patients after Fontan palliation were frail which was associated with lower physical functioning and higher healthcare utilization. Providers poorly recognized frailty. These findings highlight the need for improved screening and support for an at-risk population where frailty is not easily identified. CI - (c) 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Wilde, Megan M AU - Wilde MM AUID- ORCID: 0000-0002-7141-4409 AD - Division of Pediatric Cardiology, Department of Pediatrics, Indiana University, Indianapolis, IN, USA. FAU - Schumacher, Kurt R AU - Schumacher KR AUID- ORCID: 0000-0001-8659-736X AD - Division of Pediatric Cardiology, Department of Pediatrics, Michigan Medicine, 1540 East Hospital Drive, Ann Arbor, MI, 48109-4204, USA. FAU - Yu, Sunkyung AU - Yu S AUID- ORCID: 0000-0002-3995-1765 AD - Division of Pediatric Cardiology, Department of Pediatrics, Michigan Medicine, 1540 East Hospital Drive, Ann Arbor, MI, 48109-4204, USA. FAU - Lowery, Ray AU - Lowery R AD - Division of Pediatric Cardiology, Department of Pediatrics, Michigan Medicine, 1540 East Hospital Drive, Ann Arbor, MI, 48109-4204, USA. FAU - Stoscup, Jessica AU - Stoscup J AD - Division of Pediatric Cardiology, Department of Pediatrics, Michigan Medicine, 1540 East Hospital Drive, Ann Arbor, MI, 48109-4204, USA. FAU - Uzark, Karen AU - Uzark K AUID- ORCID: 0000-0002-7303-7635 AD - Department of Cardiac Surgery, Michigan Medicine, Ann Arbor, MI, USA. FAU - Lim, Heang M AU - Lim HM AUID- ORCID: 0000-0002-8838-9019 AD - Division of Pediatric Cardiology, Department of Pediatrics, Michigan Medicine, 1540 East Hospital Drive, Ann Arbor, MI, 48109-4204, USA. HeangL@med.umich.edu. LA - eng PT - Journal Article DEP - 20241004 PL - United States TA - Pediatr Cardiol JT - Pediatric cardiology JID - 8003849 SB - IM MH - Humans MH - Male MH - *Fontan Procedure/adverse effects MH - Female MH - Child MH - Adolescent MH - *Frailty/epidemiology/diagnosis/etiology MH - Risk Factors MH - Prospective Studies MH - Quality of Life MH - Young Adult MH - *Heart Defects, Congenital/surgery MH - Prevalence OTO - NOTNLM OT - Congenital heart disease OT - Fontan OT - Frailty OT - Pediatric COIS- Declarations. Conflict of interest: The authors have no disclosures. EDAT- 2024/10/05 11:43 MHDA- 2025/11/03 16:06 CRDT- 2024/10/04 23:28 PHST- 2024/08/09 00:00 [received] PHST- 2024/09/19 00:00 [accepted] PHST- 2025/11/03 16:06 [medline] PHST- 2024/10/05 11:43 [pubmed] PHST- 2024/10/04 23:28 [entrez] AID - 10.1007/s00246-024-03661-z [pii] AID - 10.1007/s00246-024-03661-z [doi] PST - ppublish SO - Pediatr Cardiol. 2025 Dec;46(8):2339-2347. doi: 10.1007/s00246-024-03661-z. Epub 2024 Oct 4. PMID- 39364512 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241005 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 16 IP - 9 DP - 2024 Sep TI - Understanding the Crisis: Prevalence and Key Determinants of Stunting in Children Aged 2 to 5 Years in an Afghan Refugee Camp in Kohat. PG - e68426 LID - 10.7759/cureus.68426 [doi] LID - e68426 AB - BACKGROUND: Stunting, characterized by impaired growth and development due to malnutrition and illness, is a significant public health concern with profound implications for cognitive and physical development. This issue is particularly severe in refugee settings, where food insecurity and limited access to healthcare exacerbate the problem. OBJECTIVE: This study aimed to evaluate the prevalence and determinants of stunting among children aged 2 to 5 years in an Afghan refugee camp in Kohat, Pakistan. METHODS: A cross-sectional observational design was employed, collecting data from children aged 2 to 5 years who had resided in the camp for at least six months. A pre-validated, standardized questionnaire was administered to parents or guardians to gather data on socio-demographic factors, dietary intake, and health history. Stunting was defined as a height-for-age Z-score less than -2 SD from the median of the WHO Child Growth Standards. Anthropometric measurements were taken following WHO guidelines. Bivariate and multivariate logistic regression analyses were conducted to identify predictors of stunting. RESULTS: Out of 384 children, 153 (40%) were found to be stunted. The prevalence was slightly higher among boys (80 out of 153, 52%) compared to girls (73 out of 153, 48%). Significant predictors of stunting included a lack of parental education (adjusted odds ratio (AOR) for fathers 1.8, 95% confidence level (CI) 1.2-2.9; AOR for mothers 2.1, 95% CI 1.3-3.4), a history of infectious diseases (AOR 1.9, 95% CI 1.2-3.0), and low dietary diversity (AOR 2.3, 95% CI 1.4-3.7). CONCLUSION: The study highlights the high prevalence of stunting among children in the refugee camp, underscoring the need for comprehensive interventions targeting healthcare improvement, parental education, economic support, and dietary diversity to reduce stunting rates and improve children's health outcomes. CI - Copyright (c) 2024, Khan et al. FAU - Khan, Inayatullah AU - Khan I AD - Pediatric Medicine, Lady Reading Hospital Medical Teaching Institute, Peshawar, PAK. FAU - Ullah, Sami AU - Ullah S AD - Pediatric Medicine, Lady Reading Hospital Medical Teaching Institute, Peshawar, PAK. FAU - Ayesha AU - Ayesha AD - Pediatric Medicine, Pak International Medical College, Peshawar, PAK. FAU - Khan, Muhammad AU - Khan M AD - Pediatric Medicine, Lady Reading Hospital Medical Teaching Institute, Peshawar, PAK. FAU - Shafiq, Fatima AU - Shafiq F AD - Pediatric Medicine, Lady Reading Hospital Medical Teaching Institute, Peshawar, PAK. FAU - Syed, Annam AU - Syed A AD - Pediatric Medicine, Lady Reading Hospital Medical Teaching Institute, Peshawar, PAK. FAU - Ullah Khan, Jabran AU - Ullah Khan J AD - Pediatric Medicine, Lady Reading Hospital Medical Teaching Institute, Peshawar, PAK. FAU - Khan, Fahad R AU - Khan FR AD - Cardiology, Lady Reading Hospital Medical Teaching Institute, Peshawar, PAK. LA - eng PT - Journal Article DEP - 20240902 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC11449377 OTO - NOTNLM OT - afghan refugee children OT - dietary diversity OT - infectious diseases OT - kohat OT - nutritional interventions OT - socio-economic factors OT - stunting COIS- Human subjects: Consent was obtained or waived by all participants in this study. Institutional Review Board (IRB) of Lady Reading Hospital Medical Teaching Institute issued approval IRB/LRH/MTI/2023/598. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2024/10/04 11:09 MHDA- 2024/10/04 11:10 PMCR- 2024/09/02 CRDT- 2024/10/04 04:31 PHST- 2024/09/02 00:00 [accepted] PHST- 2024/10/04 11:10 [medline] PHST- 2024/10/04 11:09 [pubmed] PHST- 2024/10/04 04:31 [entrez] PHST- 2024/09/02 00:00 [pmc-release] AID - 10.7759/cureus.68426 [doi] PST - epublish SO - Cureus. 2024 Sep 2;16(9):e68426. doi: 10.7759/cureus.68426. eCollection 2024 Sep. PMID- 39357992 OWN - NLM STAT- MEDLINE DCOM- 20241107 LR - 20241123 IS - 1759-2887 (Electronic) IS - 1759-2879 (Linking) VI - 15 IP - 6 DP - 2024 Nov TI - Mapping between measurement scales in meta-analysis, with application to measures of body mass index in children. PG - 1072-1093 LID - 10.1002/jrsm.1758 [doi] AB - Quantitative evidence synthesis methods aim to combine data from multiple medical trials to infer relative effects of different interventions. A challenge arises when trials report continuous outcomes on different measurement scales. To include all evidence in one coherent analysis, we require methods to "map" the outcomes onto a single scale. This is particularly challenging when trials report aggregate rather than individual data. We are motivated by a meta-analysis of interventions to prevent obesity in children. Trials report aggregate measurements of body mass index (BMI) either expressed as raw values or standardized for age and sex. We develop three methods for mapping between aggregate BMI data using known or estimated relationships between measurements on different scales at the individual level. The first is an analytical method based on the mathematical definitions of z-scores and percentiles. The other two approaches involve sampling individual participant data on which to perform the conversions. One method is a straightforward sampling routine, while the other involves optimization with respect to the reported outcomes. In contrast to the analytical approach, these methods also have wider applicability for mapping between any pair of measurement scales with known or estimable individual-level relationships. We verify and contrast our methods using simulation studies and trials from our data set which report outcomes on multiple scales. We find that all methods recreate mean values with reasonable accuracy, but for standard deviations, optimization outperforms the other methods. However, the optimization method is more likely to underestimate standard deviations and is vulnerable to non-convergence. CI - (c) 2024 The Author(s). Research Synthesis Methods published by John Wiley & Sons Ltd. FAU - Davies, Annabel L AU - Davies AL AUID- ORCID: 0000-0003-2320-7701 AD - Bristol Medical School, University of Bristol, Bristol, UK. FAU - Ades, A E AU - Ades AE AUID- ORCID: 0000-0001-7822-3552 AD - Bristol Medical School, University of Bristol, Bristol, UK. FAU - Higgins, Julian P T AU - Higgins JPT AUID- ORCID: 0000-0002-8323-2514 AD - Bristol Medical School, University of Bristol, Bristol, UK. LA - eng GR - National Institute for Health and Care Research/ PT - Journal Article DEP - 20241002 PL - England TA - Res Synth Methods JT - Research synthesis methods JID - 101543738 SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Male MH - *Body Mass Index MH - Data Interpretation, Statistical MH - *Meta-Analysis as Topic MH - *Models, Statistical MH - Obesity MH - Pediatric Obesity MH - Reproducibility of Results MH - Research Design OTO - NOTNLM OT - body mass index OT - mapping OT - meta-analysis OT - optimization OT - sampling OT - standardization EDAT- 2024/10/03 00:42 MHDA- 2024/11/12 04:18 CRDT- 2024/10/02 21:12 PHST- 2024/08/22 00:00 [revised] PHST- 2024/02/28 00:00 [received] PHST- 2024/08/23 00:00 [accepted] PHST- 2024/11/12 04:18 [medline] PHST- 2024/10/03 00:42 [pubmed] PHST- 2024/10/02 21:12 [entrez] AID - 10.1002/jrsm.1758 [doi] PST - ppublish SO - Res Synth Methods. 2024 Nov;15(6):1072-1093. doi: 10.1002/jrsm.1758. Epub 2024 Oct 2. PMID- 39353139 OWN - NLM STAT- MEDLINE DCOM- 20241015 LR - 20260415 IS - 1520-5851 (Electronic) IS - 0013-936X (Print) IS - 0013-936X (Linking) VI - 58 IP - 41 DP - 2024 Oct 15 TI - Metabolomic Alterations Associated with Phthalate Exposures among Pregnant Women in Puerto Rico. PG - 18076-18087 LID - 10.1021/acs.est.4c03006 [doi] AB - Although phthalate exposure has been linked with multiple adverse pregnancy outcomes, their underlying biological mechanisms are not fully understood. We examined associations between biomarkers of phthalate exposures and metabolic alterations using untargeted metabolomics in 99 pregnant women and 86 newborns [mean (SD) gestational age = 39.5 (1.5) weeks] in the PROTECT cohort. Maternal urinary phthalate metabolites were quantified using isotope dilution high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS), while metabolic profiles in maternal and cord blood plasma were characterized via reversed-phase LC-MS. Multivariable linear regression was used in metabolome-wide association studies (MWAS) to identify individual metabolic features associated with elevated phthalate levels, while clustering and correlation network analyses were used to discern the interconnectedness of biologically relevant features. In the MWAS adjusted for maternal age and prepregnancy BMI, we observed significant associations between specific phthalates, namely, di(2-ethylhexyl) phthalate (DEHP) and mono(3-carboxypropyl) phthalate (MCPP), and 34 maternal plasma metabolic features. These associations predominantly included upregulation of fatty acids, amino acids, purines, or their derivatives and downregulation of ceramides and sphingomyelins. In contrast, fewer significant associations were observed with metabolic features in cord blood. Correlation network analysis highlighted the overlap of features associated with phthalates and those identified as differentiating markers for preterm birth in a previous study. Overall, our findings underscore the complex impact of phthalate exposures on maternal and fetal metabolism, highlighting metabolomics as a tool for understanding associated biological processes. Future research should focus on expanding the sample size, exploring the effects of phthalate mixtures, and validating identified metabolic features in larger, more diverse populations. FAU - Siwakoti, Ram C AU - Siwakoti RC AD - University of Michigan, Ann Arbor, Michigan 48105, United States. FAU - Iyer, Gayatri AU - Iyer G AUID- ORCID: 0000-0002-8100-0832 AD - University of Michigan, Ann Arbor, Michigan 48105, United States. FAU - Banker, Margaret AU - Banker M AD - Northwestern University, Chicago, Illinois 60611, United States. FAU - Rosario, Zaira AU - Rosario Z AD - University of Puerto Rico Medical Sciences Campus, San Juan 00921, Puerto Rico. FAU - Velez-Vega, Carmen M AU - Velez-Vega CM AD - University of Puerto Rico Medical Sciences Campus, San Juan 00921, Puerto Rico. FAU - Alshawabkeh, Akram AU - Alshawabkeh A AD - Northeastern University, Boston, Massachusetts 02115, United States. FAU - Cordero, Jose F AU - Cordero JF AD - University of Georgia, Athens, Georgia 30602, United States. FAU - Karnovsky, Alla AU - Karnovsky A AUID- ORCID: 0000-0001-7388-8520 AD - University of Michigan, Ann Arbor, Michigan 48105, United States. FAU - Meeker, John D AU - Meeker JD AD - University of Michigan, Ann Arbor, Michigan 48105, United States. FAU - Watkins, Deborah J AU - Watkins DJ AUID- ORCID: 0000-0002-6692-2206 AD - University of Michigan, Ann Arbor, Michigan 48105, United States. LA - eng GR - P42 ES017198/ES/NIEHS NIH HHS/United States GR - R01 ES007062/ES/NIEHS NIH HHS/United States GR - P30 DK089503/DK/NIDDK NIH HHS/United States GR - UG3 OD023251/OD/NIH HHS/United States GR - P01 ES022844/ES/NIEHS NIH HHS/United States GR - P30 ES017885/ES/NIEHS NIH HHS/United States GR - UH3 OD023251/OD/NIH HHS/United States GR - R01 ES032203/ES/NIEHS NIH HHS/United States GR - T32 ES007062/ES/NIEHS NIH HHS/United States PT - Journal Article DEP - 20241001 PL - United States TA - Environ Sci Technol JT - Environmental science & technology JID - 0213155 RN - 0 (Phthalic Acids) RN - 6O7F7IX66E (phthalic acid) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - *Phthalic Acids/urine MH - Pregnancy MH - Adult MH - *Metabolomics MH - Puerto Rico MH - Maternal Exposure MH - Infant, Newborn MH - Fetal Blood/chemistry/metabolism MH - Biomarkers/blood MH - Metabolome MH - Environmental Exposure PMC - PMC11736900 MID - NIHMS2046787 OTO - NOTNLM OT - amino acids OT - cord blood OT - lipids OT - phthalates OT - pregnancy OT - purines COIS- The authors declare no competing financial interest. EDAT- 2024/10/03 03:38 MHDA- 2024/10/15 06:22 PMCR- 2025/10/15 CRDT- 2024/10/01 15:43 PHST- 2024/10/15 06:22 [medline] PHST- 2024/10/03 03:38 [pubmed] PHST- 2024/10/01 15:43 [entrez] PHST- 2025/10/15 00:00 [pmc-release] AID - 10.1021/acs.est.4c03006 [doi] PST - ppublish SO - Environ Sci Technol. 2024 Oct 15;58(41):18076-18087. doi: 10.1021/acs.est.4c03006. Epub 2024 Oct 1. PMID- 39356742 OWN - NLM STAT- MEDLINE DCOM- 20241204 LR - 20250430 IS - 1535-1386 (Electronic) IS - 0021-9355 (Linking) VI - 106 IP - 23 DP - 2024 Dec 4 TI - Validation of Examination Maneuvers for Adolescent Idiopathic Scoliosis in the Telehealth Setting. PG - 2249-2255 LID - 10.2106/JBJS.23.01146 [doi] AB - BACKGROUND: Telehealth visits (THVs) have made it essential to adopt innovative ways to evaluate patients virtually. This study validates a novel THV approach that uses educational videos and an instructional datasheet, enabling parents to use smartphones to measure their child's scoliosis at home or in telehealth settings. METHODS: We identified a prospective cohort of patients with adolescent idiopathic scoliosis (AIS) scheduled for follow-up care from March to July 2021. The angle of trunk rotation (ATR) was first measured at home by patients' guardians using instructional video guidance and a smartphone application with internal accelerometer software. The second measurement was made during a THV examination performed by caregivers with supervision by trained associates via a telehealth appointment. Lastly, the clinician measured the child's ATR during an in-person clinic visit. Intraclass correlation coefficients (ICCs) and interrater reliability were compared between in-person clinic measurements and (1) at-home and (2) THV measurements. Shoulder, lower back, and pelvic asymmetry were observed and quantified at home and virtually, and then were compared with in-person clinic evaluations using kappa values. Surveys were used to evaluate the experience of the patient/caregiver with the at-home and telehealth assessment tools. RESULTS: Seventy-three patients were included (mean age, 14.1 years; 25% male). There was excellent agreement in the ATR measurements between THVs and in-person visits (ICC = 0.88; 95% confidence interval [CI] = 0.83 to 0.92). ATR agreement between at-home and in-person visits was also excellent, but slightly diminished (ICC = 0.76; 95% CI = 0.64 to 0.83). Agreement between THV and in-person measurements was significantly higher compared with that between at-home and in-person measurements (p = 0.04). There was poor agreement in lower back asymmetry between THV and in-person assessments (kappa = 0.37; 95% CI = 0.14 to 0.60); however, there was no significant agreement between at-home and in-person assessments (kappa = 0.06; 95% CI = -0.17 to 0.29). Patient/caregiver satisfaction surveys (n = 70) reported a median score of 4 ("good") for comfort with use of the technology, and a score of 3 ("neutral") for equivalence of THV and in-person evaluation. CONCLUSIONS: There was a high level of agreement between telehealth and in-person spine measurements, suggesting that THVs may be reliably used to evaluate AIS, thus improving access to specialized care. LEVEL OF EVIDENCE: Diagnostic Level II . See Instructions for Authors for a complete description of levels of evidence. CI - Copyright (c) 2024 by The Journal of Bone and Joint Surgery, Incorporated. FAU - Farid, Alexander R AU - Farid AR AUID- ORCID: 0000-0003-4558-3900 AD - Harvard Combined Orthopaedic Residency Program, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts. FAU - Hresko, M Timothy AU - Hresko MT AUID- ORCID: 0000-0002-8769-0969 AD - Harvard Medical School, Boston, Massachusetts. AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. FAU - Ghessese, Semhal AU - Ghessese S AUID- ORCID: 0000-0001-9751-9180 AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. FAU - Linden, Gabriel S AU - Linden GS AUID- ORCID: 0009-0009-6792-9395 AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. FAU - Wong, Stephanie AU - Wong S AUID- ORCID: 0000-0001-9144-7841 AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. FAU - Hedequist, Daniel AU - Hedequist D AUID- ORCID: 0000-0002-4067-5665 AD - Harvard Medical School, Boston, Massachusetts. AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. FAU - Birch, Craig AU - Birch C AUID- ORCID: 0000-0001-5168-4623 AD - Harvard Medical School, Boston, Massachusetts. AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. FAU - Cook, Danielle AU - Cook D AUID- ORCID: 0009-0002-5327-7903 AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. FAU - Flowers, Kelsey Mikayla AU - Flowers KM AUID- ORCID: 0000-0002-6566-046 AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. FAU - Hogue, Grant D AU - Hogue GD AUID- ORCID: 0000-0001-7507-0511 AD - Harvard Medical School, Boston, Massachusetts. AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. LA - eng PT - Journal Article PT - Validation Study DEP - 20241002 PL - United States TA - J Bone Joint Surg Am JT - The Journal of bone and joint surgery. American volume JID - 0014030 SB - IM MH - Humans MH - *Scoliosis/therapy/diagnosis MH - Adolescent MH - Female MH - Male MH - *Telemedicine MH - Prospective Studies MH - Physical Examination/methods MH - Reproducibility of Results MH - Child MH - Smartphone COIS- Disclosure: No external funding was received for this study. The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article ( http://links.lww.com/JBJS/I224 ). EDAT- 2024/10/02 19:01 MHDA- 2024/12/04 12:28 CRDT- 2024/10/02 14:02 PHST- 2024/12/04 12:28 [medline] PHST- 2024/10/02 19:01 [pubmed] PHST- 2024/10/02 14:02 [entrez] AID - 00004623-202412040-00009 [pii] AID - 10.2106/JBJS.23.01146 [doi] PST - ppublish SO - J Bone Joint Surg Am. 2024 Dec 4;106(23):2249-2255. doi: 10.2106/JBJS.23.01146. Epub 2024 Oct 2. PMID- 39352577 OWN - NLM STAT- MEDLINE DCOM- 20241012 LR - 20250711 IS - 1573-2606 (Electronic) IS - 1389-9155 (Print) IS - 1389-9155 (Linking) VI - 25 IP - 5 DP - 2024 Oct TI - Continuous glucose monitoring in patients with inherited metabolic disorders at risk for Hypoglycemia and Nutritional implications. PG - 897-910 LID - 10.1007/s11154-024-09903-y [doi] AB - Managing Inherited Metabolic Disorders (IMDs) at risk for hypoglycemia, such as Glycogen Storage Diseases (GSDs), Hereditary Fructose Metabolism Disorders (HFMDs) and Congenital Hyperinsulinism (CH), poses challenges in dietary treatments and blood glucose monitoring. The effectiveness of Continuous Glucose Monitoring (CGM) remains a subject of ongoing debate, with IMD guidelines maintaining caution. Therefore, a systematic evaluation is needed to understand the potential benefits of CGM during dietary interventions. A systematic literature review was conducted in PubMed according to the PICOS model and PRISMA recommendations on studies published from January 01, 2003, up to October 15, 2023 (PROSPERO CRD42024497744). The risk of bias was assessed using NIH Quality Assessment Tools. Twenty-four studies in GSDs (n = 13), CH (n = 10), and HFMDs (n = 1) were analyzed. In GSDs, Real-time CGM (Rt-CGM) was associated with metabolic benefits during nutritional interventions, proving to be an accurate system for hypoglycemia detection although with some concerns about reliability. Rt-CGM in CH, primarily involving children, also showed potential benefits for glycemic control and metabolic stability with acceptable accuracy, although its use during dietary changes was limited. Few experiences on Flash Glucose Monitoring (FGM) were reported, with some concerns about reliability. Overall, the studies analyzed presented different designs, and their quality was predominantly fair or poor. Heterogeneity and limited consensus on reliability and glycemic targets underscore the need for prospective studies and future recommendations for the use of CGM in optimizing nutritional status and providing personalized dietary education in individuals with IMDs prone to hypoglycemia. CI - (c) 2024. The Author(s). FAU - Gugelmo, Giorgia AU - Gugelmo G AUID- ORCID: 0000-0002-3557-8078 AD - Division of Metabolic Diseases, Department of Medicine, Padova University Hospital, Padova, 35128, Italy. FAU - Maines, Evelina AU - Maines E AUID- ORCID: 0000-0002-0445-2974 AD - Division of Pediatrics, Santa Chiara General Hospital, APSS, Trento, 38122, Italy. FAU - Boscari, Federico AU - Boscari F AUID- ORCID: 0000-0002-9670-615X AD - Division of Metabolic Diseases, Department of Medicine, Padova University Hospital, Padova, 35128, Italy. FAU - Lenzini, Livia AU - Lenzini L AUID- ORCID: 0000-0001-6146-3015 AD - Department of Medicine, Padova University Hospital, Padova, 35128, Italy. FAU - Fadini, Gian Paolo AU - Fadini GP AUID- ORCID: 0000-0002-6510-2097 AD - Division of Metabolic Diseases, Department of Medicine, Padova University Hospital, Padova, 35128, Italy. FAU - Burlina, Alberto AU - Burlina A AUID- ORCID: 0000-0001-7724-137X AD - Division of Inherited Metabolic Diseases, Reference Centre Expanded Newborn Screening, Department of Women's and Children's Health, Padova University Hospital, Padova, 35128, Italy. FAU - Avogaro, Angelo AU - Avogaro A AUID- ORCID: 0000-0002-1177-0516 AD - Division of Metabolic Diseases, Department of Medicine, Padova University Hospital, Padova, 35128, Italy. FAU - Vitturi, Nicola AU - Vitturi N AUID- ORCID: 0000-0002-5147-4367 AD - Division of Metabolic Diseases, Department of Medicine, Padova University Hospital, Padova, 35128, Italy. nicola.vitturi@aopd.veneto.it. LA - eng PT - Journal Article PT - Systematic Review DEP - 20241001 PL - Germany TA - Rev Endocr Metab Disord JT - Reviews in endocrine & metabolic disorders JID - 100940588 RN - 0 (Blood Glucose) SB - IM MH - Humans MH - *Hypoglycemia/prevention & control/blood MH - *Blood Glucose/analysis/metabolism MH - Blood Glucose Self-Monitoring/methods MH - Metabolic Diseases/prevention & control/blood MH - Continuous Glucose Monitoring PMC - PMC11470883 OTO - NOTNLM OT - Continuous glucose monitoring OT - Dietetic therapy OT - Glycogen storage diseases, congenital hyperinsulinism OT - Inherited metabolic disorders OT - Nutrition COIS- G.G., E.M., L.L., G.P.F., A.B., A.A. and N.V. have nothing to declare. F.B. reports a relationship as a board membership with Glooko, Roche and a relationship with Roche, Sanofi Aventis, novo Nordisk, Ascensia that includes speaking and lecture fees. EDAT- 2024/10/01 12:43 MHDA- 2024/10/12 21:47 PMCR- 2024/10/01 CRDT- 2024/10/01 11:16 PHST- 2024/08/26 00:00 [accepted] PHST- 2024/10/12 21:47 [medline] PHST- 2024/10/01 12:43 [pubmed] PHST- 2024/10/01 11:16 [entrez] PHST- 2024/10/01 00:00 [pmc-release] AID - 10.1007/s11154-024-09903-y [pii] AID - 9903 [pii] AID - 10.1007/s11154-024-09903-y [doi] PST - ppublish SO - Rev Endocr Metab Disord. 2024 Oct;25(5):897-910. doi: 10.1007/s11154-024-09903-y. Epub 2024 Oct 1. PMID- 39351682 OWN - NLM STAT- MEDLINE DCOM- 20241018 LR - 20241018 IS - 1466-447X (Electronic) IS - 0264-0414 (Linking) VI - 42 IP - 18 DP - 2024 Sep TI - Physical and technical attributes associated with on-water rowing performance in junior and elite rowers. PG - 1716-1726 LID - 10.1080/02640414.2024.2408521 [doi] AB - On-water rowing performance consists of the integration of physical and technical attributes. This exploratory study aimed to describe key physical and technical variables for elite and junior rowers and examine the associations and predictive capacity of these variables with on-water rowing performance outcomes. Twenty-eight junior (16 females, 16 +/- 0.8 years and 12 males, 17 +/- 0.7 years) and 24 elite rowers (12 females, 24 +/- 2.7 years and 12 males, 27 +/- 2.6 years) completed an on-water, single sculling biomechanics assessment combined with a series of physical, strength and power tests. Elite men and women were superior in mean gate force, distance per stroke and recovery distance compared to junior groups as determined by independent t-tests and effect size appraisal (p < 0.017, d > 1.2). Large associations (p < 0.01) were evident between anthropometry, strength and power assessments with the on-water measures of catch angle, mean gate force, recovery distance and boat speed. Differences in ROM and flexibility attributes did not distinguish between elite and junior rowers. Linear discriminant analysis revealed that individual rowers can be appropriately categorised by sex and performance level based on their physical and technical attributes. This battery of testing with world-class athletes represents an excellent level of ecological validity for the assessment of rowers pertinent to on-water performance. FAU - Legge, Natalie AU - Legge N AUID- ORCID: 0000-0001-6607-5732 AD - Faculty of Health, School of Sport, Exercise and Rehabilitation, Human Performance Research Centre, University of Technology Sydney, Ultimo, NSW, Australia. FAU - Slattery, Katie AU - Slattery K AD - Faculty of Health, School of Sport, Exercise and Rehabilitation, Human Performance Research Centre, University of Technology Sydney, Ultimo, NSW, Australia. FAU - O'Meara, Damien AU - O'Meara D AD - Sport Science Department, NSW Institute of Sport, Sydney, NSW, Australia. FAU - McCleave, Erin AU - McCleave E AD - Sport Science Department, Rowing Australia, Yarralumla, ACT, Australia. FAU - Young, David AU - Young D AD - Sport Science Department, NSW Institute of Sport, Sydney, NSW, Australia. FAU - Crichton, Sophie AU - Crichton S AD - Faculty of Health, School of Sport, Exercise and Rehabilitation, Human Performance Research Centre, University of Technology Sydney, Ultimo, NSW, Australia. FAU - Watsford, Mark AU - Watsford M AD - Faculty of Health, School of Sport, Exercise and Rehabilitation, Human Performance Research Centre, University of Technology Sydney, Ultimo, NSW, Australia. LA - eng PT - Journal Article DEP - 20241001 PL - England TA - J Sports Sci JT - Journal of sports sciences JID - 8405364 SB - IM MH - Humans MH - *Water Sports/physiology MH - Male MH - Female MH - *Athletic Performance/physiology MH - Adolescent MH - Young Adult MH - Biomechanical Phenomena MH - Adult MH - *Muscle Strength/physiology MH - Anthropometry MH - Ships MH - Exercise Test OTO - NOTNLM OT - On-water rowing OT - performance OT - physical attributes OT - sculling OT - technique EDAT- 2024/10/01 06:56 MHDA- 2024/10/18 06:23 CRDT- 2024/10/01 05:12 PHST- 2024/10/18 06:23 [medline] PHST- 2024/10/01 06:56 [pubmed] PHST- 2024/10/01 05:12 [entrez] AID - 10.1080/02640414.2024.2408521 [doi] PST - ppublish SO - J Sports Sci. 2024 Sep;42(18):1716-1726. doi: 10.1080/02640414.2024.2408521. Epub 2024 Oct 1. PMID- 39351103 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241003 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 15 DP - 2024 TI - Effects of perceived variety-support on middle school students' learning engagement in physical education: the mediating role of motivation. PG - 1459362 LID - 10.3389/fpsyg.2024.1459362 [doi] LID - 1459362 AB - INTRODUCTION: High engagement in physical education (PE) could effectively develop students' motor competence and promote physical activity, which was significantly important for students' physical and mental health. Researches had shown that motivation was an important factor in explaining students' learning engagement, and variety-support as the fourth independent psychological need was a potential factor influencing students' learning motivation. However, there was a lack of empirical research evidence on the effect of perceived variety-support on middle school students' learning engagement in PE and the influencing mechanisms. This study aimed to investigate the direct effect of perceived variety-support on learning engagement in PE and the mediating effect of motivation in PE on the relationship. METHODS: A cross-sectional study was conducted and 587 middle school students from Liaoning province filled the paper-and-pencil questionnaires adopting perceived variety-support in PE scale (PVSPES), utrecht work engagement scale-student (UWES-S), and perceived locus of causality in PE scale, which had been proved to have good reliability and validity (294 boys and 293 girls, Mage=13.47 +/- 0.94). RESULTS: The results showed three variables were significantly positively correlated with each other (r = 0.323-0.562 p < 0.01) and perceived variety-support in PE could not only directly promote middle school students' learning engagement in PE but also indirectly through the mediating effect of motivation in PE. DISCUSSION: Therefore, in order to better promote students' participation in PE class, we should pay more attention to satisfy students' varied PE learning needs and stimulate students' autonomous learning motivation. CI - Copyright (c) 2024 Miao, Chai, Xue and Wang. FAU - Miao, Miao AU - Miao M AD - Department of Basic Courses, Shanxi Youth Vocational College, Taiyuan, China. AD - School of Education, Beijing Sport University, Beijing, China. FAU - Chai, Hongqin AU - Chai H AD - College of P.E. and Sports, Beijing Normal University, Beijing, China. FAU - Xue, Rui AU - Xue R AD - School of Education, Beijing Sport University, Beijing, China. FAU - Wang, Qi AU - Wang Q AD - College of P.E. and Sports, Beijing Normal University, Beijing, China. LA - eng PT - Journal Article DEP - 20240916 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC11439773 OTO - NOTNLM OT - learning engagement OT - middle school students OT - motivation OT - perceived variety-support OT - physical education COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/10/01 06:55 MHDA- 2024/10/01 06:56 PMCR- 2024/09/16 CRDT- 2024/10/01 04:19 PHST- 2024/07/04 00:00 [received] PHST- 2024/08/27 00:00 [accepted] PHST- 2024/10/01 06:56 [medline] PHST- 2024/10/01 06:55 [pubmed] PHST- 2024/10/01 04:19 [entrez] PHST- 2024/09/16 00:00 [pmc-release] AID - 10.3389/fpsyg.2024.1459362 [doi] PST - epublish SO - Front Psychol. 2024 Sep 16;15:1459362. doi: 10.3389/fpsyg.2024.1459362. eCollection 2024. PMID- 39347821 OWN - NLM STAT- MEDLINE DCOM- 20250424 LR - 20260924 IS - 1439-6327 (Electronic) IS - 1439-6319 (Print) IS - 1439-6319 (Linking) VI - 125 IP - 2 DP - 2025 Feb TI - Ratings of perceived exertion (RPE) from a submaximal 20-m shuttle-run test accurately predict children's VO(2peak), but when should we stop the test? PG - 551-559 LID - 10.1007/s00421-024-05618-9 [doi] AB - PURPOSE: The purpose of the study was to explore the validity, test-retest reliability and affective responses of a submaximal 20-m shuttle-run test (20mSRT) stopped at 6 on the Eston-Parfitt (EP) scale. The secondary aim was to examine and compare two submaximal 20mSRT protocols with different RPE end points (EP6 vs. EP7) using previously published data. METHODS: Twenty-five children (16 boys; 13.4 +/- 1.0 years; 162.1 +/- 8.7 cm; 49.1 +/- 6.6 kg) completed three exercise tests (graded exercise test [GXT], 2 submaximal 20mSRT). The EP scale and Feeling scale were used to measure RPE and affect, respectively. The two submaximal 20mSRTs were stopped after participants reported EP6. Individual speed-RPE relationships from the submaximal 20mSRTs were linearly regressed to predict peak speed and then used to estimate VO(2peak). Previously published data (n = 25) used comparable methods, except that the participants stopped at EP7. RESULTS: In the EP6 protocol, a two-factor repeated measures ANOVA revealed non-significant Test and Sex main effects (p > 0.05). Reliability analysis revealed intraclass correlation coefficient of ~ 0.7 (95%CI [0.432,0.867], p < 0.001) between the submaximal 20mSRTs. Significant differences in end-test affect between the GXT and submaximal 20mSRTs were found (p < 0.001), with GXT more negative. ANOVA revealed no significant differences in end-test affect between EP6 and EP7 protocols; however, frequency count analysis revealed EP6 to result in more positive end-test affect. CONCLUSION: Submaximal 20mSRT utilising RPE may offer valid predictions in VO(2peak) while minimising negative affect. Test end points of EP6 and EP7 both offer valid predictions in VO(2peak). EP6 may be more beneficial in avoiding negative affect, even though a reduction in test-retest reliability was observed. CI - (c) 2024. The Author(s). FAU - Kasai, Daiki AU - Kasai D AUID- ORCID: 0000-0002-4217-4127 AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, City East Campus, Cnr of North Terrace & Frome Rd, Adelaide, SA, 5001, Australia. Daiki.Kasai@mymail.unisa.edu.au. FAU - Tsiros, Margarita D AU - Tsiros MD AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, City East Campus, Cnr of North Terrace & Frome Rd, Adelaide, SA, 5001, Australia. AD - Innovation, Implementation and Clinical Translation in Health (IIMPACT), University of South Australia, City East Campus, Cnr of North Terrace & Frome Rd, Adelaide, SA, 5001, Australia. FAU - Eston, Roger AU - Eston R AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, City East Campus, Cnr of North Terrace & Frome Rd, Adelaide, SA, 5001, Australia. FAU - Parfitt, Gaynor AU - Parfitt G AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, City East Campus, Cnr of North Terrace & Frome Rd, Adelaide, SA, 5001, Australia. LA - eng PT - Journal Article DEP - 20240930 PL - Germany TA - Eur J Appl Physiol JT - European journal of applied physiology JID - 100954790 SB - IM MH - Humans MH - Male MH - Female MH - *Physical Exertion/physiology MH - *Exercise Test/methods MH - *Oxygen Consumption/physiology MH - Child MH - Adolescent MH - *Perception MH - Reproducibility of Results MH - *Running/physiology PMC - PMC11829895 OTO - NOTNLM OT - Affect OT - Fitness test OT - Oxygen uptake OT - RPE COIS- Declarations. Conflict of interest: The authors have no conflict of interest to declare. EDAT- 2024/09/30 12:45 MHDA- 2025/02/16 01:31 PMCR- 2024/09/30 CRDT- 2024/09/30 11:04 PHST- 2024/07/02 00:00 [received] PHST- 2024/09/11 00:00 [accepted] PHST- 2025/02/16 01:31 [medline] PHST- 2024/09/30 12:45 [pubmed] PHST- 2024/09/30 11:04 [entrez] PHST- 2024/09/30 00:00 [pmc-release] AID - 10.1007/s00421-024-05618-9 [pii] AID - 5618 [pii] AID - 10.1007/s00421-024-05618-9 [doi] PST - ppublish SO - Eur J Appl Physiol. 2025 Feb;125(2):551-559. doi: 10.1007/s00421-024-05618-9. Epub 2024 Sep 30. PMID- 39345664 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241001 IS - 0970-0358 (Print) IS - 1998-376X (Electronic) IS - 0970-0358 (Linking) VI - 57 IP - 4 DP - 2024 Aug TI - Normative Data of Ulnar Length in Pediatric Indian Population. PG - 294-305 LID - 10.1055/s-0044-1788810 [doi] AB - Objective The aim of this study is to create clinical normative data for ulnar length in the pediatric population and to demonstrate the usefulness of such data. Materials and Methods A nationally representative sample of healthy children aged 1 day to 18 years from five centers across India was collected. The percutaneous length of the ulna was measured by using a certified calibrated measuring tape across all centers. Other variables such as geographical domicile, dominance of the hand, age, body mass index (BMI), and sex of the child were also recorded. Results In total, 1,300 children (883 males and 417 females) with age ranging from 1 day to 18 years were included in the study. Gradual lengthening of the ulna was seen in both male and female children with increasing age without a significant difference; however, at 8, 9, and 14 years, there was significant lengthening of the ulna in males compared with females although the difference was statistically insignificant at 17 years. Apropos BMI at 16 years of age, a longer ulna was observed in obese children. Later on, at 18 years, the difference in ulnar length was insignificant. South Indian children had a significantly longer ulna up to the age of 11 years, but after the age of 11 years there was no difference in ulnar length in all zones. The length of the ulna was not affected by hand dominance. There was good inter-observer agreement and reliability between different centres. Age, zone, and gender, had statistically significant effect on the length of ulna but BMI and hand dominance was not significant. Conclusion This multicentric study provides normative data on the percutaneous length of the ulna in the Indian pediatric population. Gradual lengthening of the ulna was seen in all children with increasing age. The length of the ulna was significantly more in male, obese, and in South Indian children. However, except for age, other factors become insignificant at maturity. CI - Association of Plastic Surgeons of India. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ). FAU - Thatte, M R AU - Thatte MR AD - Department of Plastic Surgery, Bombay Hospital, Mumbai, Maharashtra, India. FAU - Agarwal, Pawan AU - Agarwal P AUID- ORCID: 0000-0002-9031-8690 AD - Department of Plastic Surgery, Netaji Subhash Chandra Bose Medical College, Jabalpur, Madhya Pradesh, India. FAU - Bhat, Anil AU - Bhat A AD - Department of Hand Surgery, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India. FAU - Baba, P Umar Farooq AU - Baba PUF AD - Department of Plastic Surgery, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India. FAU - Ghanghurde, Bipin AU - Ghanghurde B AUID- ORCID: 0000-0002-6919-075X AD - Department of Plastic Surgery, Wadia Children's Hospital, Mumbai, Maharashtra, India. FAU - Pai, Mithun AU - Pai M AUID- ORCID: 0000-0003-0222-5484 AD - Department of Plastic Surgery, Netaji Subhash Chandra Bose Medical College, Jabalpur, Madhya Pradesh, India. FAU - Shah, Harsh R AU - Shah HR AD - Department of Plastic Surgery, Bombay Hospital, Mumbai, Maharashtra, India. FAU - Kulkarni, Onkar AU - Kulkarni O AUID- ORCID: 0000-0002-0731-3822 AD - Department of Plastic Surgery, Wadia Children's Hospital, Mumbai, Maharashtra, India. FAU - Dugad, Anand AU - Dugad A AUID- ORCID: 0000-0001-8133-9636 AD - Department of Plastic Surgery, Wadia Children's Hospital, Mumbai, Maharashtra, India. FAU - Saraf, Mansi AU - Saraf M AD - Department of Surgery, Netaji Subhash Chandra Bose Government Medical College, Jabalpur, Madhya Pradesh, India. FAU - B, Rajesh AU - B R AD - Department of Surgery, Netaji Subhash Chandra Bose Government Medical College, Jabalpur, Madhya Pradesh, India. FAU - Shah, Raheeb Ahmad AU - Shah RA AD - Department of Plastic Surgery, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India. FAU - Dhakar, Jagmoah Singh AU - Dhakar JS AD - Department of Community Medicine, Netaji Subhash Chandra Bose Government Medical College, Jabalpur, Madhya Pradesh, India. FAU - Sharma, Dhananjaya AU - Sharma D AD - Department of Surgery, Netaji Subhash Chandra Bose Government Medical College, Jabalpur, Madhya Pradesh, India. LA - eng PT - Journal Article DEP - 20240805 PL - Germany TA - Indian J Plast Surg JT - Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India JID - 8405356 PMC - PMC11436344 OTO - NOTNLM OT - Indian population OT - normative data OT - pediatric OT - ulnar length COIS- Conflict of Interest None declared. EDAT- 2024/09/30 12:47 MHDA- 2024/09/30 12:48 PMCR- 2024/08/01 CRDT- 2024/09/30 09:43 PHST- 2024/09/30 12:48 [medline] PHST- 2024/09/30 12:47 [pubmed] PHST- 2024/09/30 09:43 [entrez] PHST- 2024/08/01 00:00 [pmc-release] AID - IJPS-24-3-2732 [pii] AID - 10.1055/s-0044-1788810 [doi] PST - epublish SO - Indian J Plast Surg. 2024 Aug 5;57(4):294-305. doi: 10.1055/s-0044-1788810. eCollection 2024 Aug. PMID- 39344963 OWN - NLM STAT- MEDLINE DCOM- 20241222 LR - 20260923 IS - 1461-7021 (Electronic) IS - 1359-1045 (Print) IS - 1359-1045 (Linking) VI - 30 IP - 1 DP - 2025 Jan TI - The healthy habits questionnaire (HHQ): Validation of a measure designed to assess problematic influential behaviours amongst families of children living with obesity or a risk of developing obesity. PG - 157-174 LID - 10.1177/13591045241286223 [doi] AB - The 48-item Healthy Habits Questionnaire (HHQ-48) was developed to (1) monitor positive changes in family lifestyles following engagement in the Parents Plus Healthy Families (PP-HF) parent training programme and (2) be utilised as a standalone measure in clinical settings to identify and track problematic influential behaviours amongst families of children in weight-management services. This study aimed to develop and validate a brief version of the HHQ-48. The scale was administered to a cross-sectional community sample (n = 480), and on two occasions to a control sample (n = 50) and an experimental sample (n = 40) from a randomised controlled trial (RCT) of the PP-HF programme to assess test-retest reliability and sensitivity to change respectively. Exploratory and confirmatory factor analysis showed that a 23-item, 4-factor version of the HHQ (i.e., the HHQ-23) best fit the data. The scale and factor subscales had good internal consistency and test-retest reliability. They also had good concurrent and construct validity shown by significant correlations with another scale that assessed lifestyle issues, and scales that assessed parenting satisfaction, family functioning, and children's strengths and difficulties. The HHQ-23 was sensitive to change following parents completing the PP-HF programme. The HHQ-23 may, therefore, be used to monitor positive changes in family lifestyles following engagement in the PP-HF parent training programme. The HHQ-23 also shows promising potential as a standalone screening measure or as part of a larger battery of screening assessments in paediatric weight-management services. FAU - Davis, Brid Aine AU - Davis BA AUID- ORCID: 0000-0003-4606-4432 AD - UCD School of Psychology, University College Dublin, Ireland. RINGGOLD: 8797 FAU - O'Dwyer, Claire AU - O'Dwyer C AD - UCD School of Psychology, University College Dublin, Ireland. RINGGOLD: 8797 FAU - Keating, Adele AU - Keating A AD - Parents Plus Charity, The Mater Hospital, Ireland. FAU - Sharry, John AU - Sharry J AD - Parents Plus Charity, The Mater Hospital, Ireland. FAU - Murphy, Eddie AU - Murphy E AD - Primary Care Psychology, Health Service Executive, St. Fintan's Campus, Ireland. FAU - Doran, Alan AU - Doran A AD - Child and Family Centre, Health Service Executive, Our Lady's Hospital Campus, Ireland. RINGGOLD: 8004 FAU - Nearchou, Finiki AU - Nearchou F AD - UCD School of Psychology, University College Dublin, Ireland. RINGGOLD: 8797 FAU - Carr, Alan AU - Carr A AUID- ORCID: 0000-0003-4563-8852 AD - UCD School of Psychology, University College Dublin, Ireland. RINGGOLD: 8797 LA - eng PT - Journal Article PT - Validation Study DEP - 20240930 PL - England TA - Clin Child Psychol Psychiatry JT - Clinical child psychology and psychiatry JID - 9604507 SB - IM MH - Humans MH - Male MH - Female MH - Child MH - Reproducibility of Results MH - *Pediatric Obesity MH - Surveys and Questionnaires/standards MH - *Psychometrics/instrumentation/standards MH - Cross-Sectional Studies MH - Adult MH - Parents MH - Parenting/psychology MH - Health Behavior MH - Adolescent MH - Family/psychology PMC - PMC11664886 OAB - This study aimed to develop a brief version of the 48-item Healthy Habits Questionnaire (HHQ-48), which assesses how parents encourage healthy lifestyles in their children and evaluates the effectiveness of the 8-session Parents Plus - Healthy Families (PP-HF) program aimed at preventing childhood obesity. The HHQ-48 items are grouped into eight categories reflecting the PP-HF sessions: empowering parents, family connection, healthy food routines, healthy meals, active play, managing technology, restful sleep, and a happy, healthy mind. To create a shorter version of the HHQ, 480 parents completed the HHQ-48 and additional family life questionnaires online. Factor analysis identified 23 items grouped into four clusters: Screens and Routines, Activity, Parent-Child Connection, and Healthy Food & Good Example, forming the HHQ-23.The HHQ-23 showed strong correlations with the HHQ-48 and moderate correlations with other established questionnaires on children's lifestyles, parenting satisfaction, family functioning, and children's strengths and difficulties. In a test with 50 parents over eight weeks, HHQ-23 scores were stable. Scores increased for 41 parents who completed the HHQ-23 before and after the PP-HF program, demonstrating the HHQ-23's sensitivity to change. OABL- eng OTO - NOTNLM OT - Healthy lifestyle OT - diet OT - family environment OT - obesity OT - paediatric OT - parental modelling OT - physical activity OT - screentime OT - sedentary OT - sleep COIS- Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2024/09/30 12:46 MHDA- 2024/12/22 12:19 PMCR- 2024/12/23 CRDT- 2024/09/30 08:03 PHST- 2024/12/22 12:19 [medline] PHST- 2024/09/30 12:46 [pubmed] PHST- 2024/09/30 08:03 [entrez] PHST- 2024/12/23 00:00 [pmc-release] AID - 10.1177_13591045241286223 [pii] AID - 10.1177/13591045241286223 [doi] PST - ppublish SO - Clin Child Psychol Psychiatry. 2025 Jan;30(1):157-174. doi: 10.1177/13591045241286223. Epub 2024 Sep 30. PMID- 39344194 OWN - NLM STAT- MEDLINE DCOM- 20250424 LR - 20250515 IS - 1467-1107 (Electronic) IS - 1047-9511 (Linking) VI - 34 IP - 12 DP - 2024 Dec TI - Subjective fitness relates to performance and can be improved by exercise in children and young adults with heart disease. PG - 2507-2513 LID - 10.1017/S1047951124025939 [doi] AB - INTRODUCTION: The Duke Activity Status Index is used to assess an individual patient's perception of their fitness abilities. It has been validated and shown to predict actual fitness in adults but has been studied less in the paediatric population, specifically those with heart disease. This study aims to assess if the Duke Activity Status Index is associated with measured markers of physical fitness in adolescents and young adults with heart disease. METHODS: This retrospective single-centre cohort study includes patients who completed a minimum of 12 weeks of cardiac rehabilitation between 2016 and 2022. Cardiac rehabilitation outcomes included physical, performance, and psychosocial measures. A comparison between serial testing was performed using a paired t-test. Univariable and multivariable analyses for Duke Activity Status Index were performed. Data are reported as median [interquartile range]. RESULTS: Of the 118 participants (20 years-old [13.9-22.5], 53% male), 33 (28%) completed at least 12 weeks of cardiac rehabilitation. Median peak oxygen consumption was 60.1% predicted [49-72.8%], and Duke Activity Status Index was 32.6 [21.5-48.8]. On Pearson's correlation assessing the Duke Activity Status Index, there were significant associations with % predicted peak oxygen consumption (r = 0.49, p < 0.0001), 6-minute walk distance (r = 0.45, p < 0.0001), Duke Activity Status Index metabolic equivalents (r = 0.45, p < 0.0001), and dominant hand grip (r = 0.48, p < 0.0001). In multivariable analysis, the % predicted peak oxygen consumption (r = 0.40, p = 0.005) and dominant hand grip (r = 0.37, p = 0.005) remained statistically significant. CONCLUSIONS: Duke Activity Status Index is associated with measures of physical fitness in paediatric and young adults with heart disease who complete a cardiac rehabilitation program. FAU - Aronoff, Elizabeth B AU - Aronoff EB AD - Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. FAU - Chin, Clifford AU - Chin C AD - Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. AD - The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. FAU - Opotowsky, Alexander R AU - Opotowsky AR AD - Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. AD - The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. FAU - Rice, Malloree C AU - Rice MC AD - The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. FAU - Mays, Wayne A AU - Mays WA AD - The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. FAU - Knecht, Sandra K AU - Knecht SK AD - The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. FAU - Goessling, Jennah AU - Goessling J AD - The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. FAU - Powell, Adam W AU - Powell AW AUID- ORCID: 0000-0002-5537-032X AD - Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. AD - The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. LA - eng PT - Journal Article DEP - 20240930 PL - England TA - Cardiol Young JT - Cardiology in the young JID - 9200019 SB - IM MH - Humans MH - Male MH - Female MH - Retrospective Studies MH - Adolescent MH - Young Adult MH - *Heart Diseases/rehabilitation/physiopathology MH - *Physical Fitness/physiology MH - Oxygen Consumption MH - *Cardiac Rehabilitation/methods MH - *Exercise Therapy/methods MH - Child MH - Exercise Test MH - Exercise Tolerance/physiology MH - *Exercise/physiology OTO - NOTNLM OT - CHD OT - Cardiac rehabilitation OT - Duke activity status index OT - exertion OT - fitness OT - heart disease EDAT- 2024/09/30 10:18 MHDA- 2025/01/27 12:25 CRDT- 2024/09/30 02:23 PHST- 2025/01/27 12:25 [medline] PHST- 2024/09/30 10:18 [pubmed] PHST- 2024/09/30 02:23 [entrez] AID - S1047951124025939 [pii] AID - 10.1017/S1047951124025939 [doi] PST - ppublish SO - Cardiol Young. 2024 Dec;34(12):2507-2513. doi: 10.1017/S1047951124025939. Epub 2024 Sep 30. PMID- 39343693 OWN - NLM STAT- MEDLINE DCOM- 20241205 LR - 20260706 IS - 1365-229X (Electronic) IS - 0009-9260 (Linking) VI - 79 IP - 12 DP - 2024 Dec TI - Determination of the diagnostic accuracy of peritoneal biopsy with an 18G cutting needle under ultrasonography guidance and the contribution of CT findings to diagnosis before biopsy (our 8-year clinical experience). PG - e1497-e1503 LID - S0009-9260(24)00507-5 [pii] LID - 10.1016/j.crad.2024.09.002 [doi] AB - AIM: Ultrasound-guided percutaneous core needle biopsy is an important technique in diagnosing mesenteric involvement. Diagnostic results were compared with pre-biopsy CT findings. The purpose of this study was to determine the diagnostic efficiency of omental lesion biopsies performed under ultrasound guidance and to investigate the relationship between pre-biopsy diagnostic CT findings. MATERIALS AND METHODS: Demographic data of 70 patients who underwent omental biopsy under ultrasound guidance in our clinic between August 2015 and July 2023, the presence of a primary malignancy focus during the investigations conducted during the research, biopsy histopathology results, and pre-biopsy CT findings were retrospectively reviewed. RESULTS: This retrospective study included who underwent omental biopsy under ultrasound guidance, 48 (69%) were female, and 22 (31%) were male, with an average age of 61 (age range 15-95), and an average body mass index [BMI] of 27.7 +/- 6.9. Five (7%) of the 70 biopsy procedures were not pathologically diagnostic. Diagnostic results were compared with pre-biopsy CT findings. In all omental lesions, the percentage of omental infiltrative involvement in diagnostic CT was subjectively evaluated by two radiologists. 65 patients diagnosed pathologically, 47 (67%) were malignant, and 18 (26%) were benign. No complications occurred. CONCLUSION: Peritoneal biopsies under ultrasound guidance for mesenteric diseases detected on CT are a reliable procedure that can be easily applied. Ultrasonography imaging helps identify appropriate locations for targeted biopsies before deep percutaneous biopsy, increasing diagnostic accuracy, especially when omental lesions appear as infiltrative thickenings. CI - Copyright (c) 2024 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved. FAU - Cakir, C AU - Cakir C AD - University of Health Sciences, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Radiology Department, 34147, Istanbul, Turkey. Electronic address: drcakir1983@gmail.com. FAU - Inci, E AU - Inci E AD - University of Health Sciences, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Radiology Department, 34147, Istanbul, Turkey. Electronic address: ercan@inci.com. FAU - Kilinc, F AU - Kilinc F AD - University of Health Sciences, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Radiology Department, 34147, Istanbul, Turkey. Electronic address: hitafkilinc@yahoo.com. FAU - Yildiz, O AU - Yildiz O AD - University of Health Sciences, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Radiology Department, 34147, Istanbul, Turkey. Electronic address: yildiz_omer@outlook.com. LA - eng PT - Journal Article DEP - 20240907 PL - England TA - Clin Radiol JT - Clinical radiology JID - 1306016 SB - IM MH - Humans MH - Female MH - Male MH - Middle Aged MH - Adult MH - Aged MH - Retrospective Studies MH - Adolescent MH - Aged, 80 and over MH - *Tomography, X-Ray Computed/methods MH - *Image-Guided Biopsy/methods MH - *Ultrasonography, Interventional/methods MH - Young Adult MH - *Peritoneal Neoplasms/diagnostic imaging/pathology MH - Omentum/pathology/diagnostic imaging MH - Peritoneum/pathology/diagnostic imaging MH - Reproducibility of Results EDAT- 2024/09/30 00:42 MHDA- 2024/12/06 05:31 CRDT- 2024/09/29 21:53 PHST- 2024/03/04 00:00 [received] PHST- 2024/07/30 00:00 [revised] PHST- 2024/09/03 00:00 [accepted] PHST- 2024/12/06 05:31 [medline] PHST- 2024/09/30 00:42 [pubmed] PHST- 2024/09/29 21:53 [entrez] AID - S0009-9260(24)00507-5 [pii] AID - 10.1016/j.crad.2024.09.002 [doi] PST - ppublish SO - Clin Radiol. 2024 Dec;79(12):e1497-e1503. doi: 10.1016/j.crad.2024.09.002. Epub 2024 Sep 7. PMID- 39341347 OWN - NLM STAT- MEDLINE DCOM- 20241105 LR - 20260529 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 203 DP - 2024 Dec 1 TI - Streamlining COM-B model: Insights from the Healthy Eating Context. PG - 107693 LID - S0195-6663(24)00496-3 [pii] LID - 10.1016/j.appet.2024.107693 [doi] AB - The global rise in diet-related diseases highlights the urgent need for effective behavioural interventions. While theoretical frameworks like the Capability, Opportunity, Motivation-Behaviour (COM-B) model are valuable for understanding and influencing healthy eating behaviours, their practical application is often hindered by complexity and extensive measurement demands. This study addresses these challenges by testing a simplified version of the COM-B model, focusing on a select set of items representing seven core constructs. We conducted a cross-sectional survey with 347 Australian young adults to validate this streamlined model, making it more accessible for researchers and practitioners. Our findings underscore the importance of automatic motivation, the physical environment, and physical capability as critical factors in promoting healthy eating behaviours. By simplifying the COM-B model, this research contributes to developing more practical and effective strategies for healthier eating, addressing a critical public health issue. CI - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Isbanner, Sebastian AU - Isbanner S AD - Education for Sustainable Nutrition and Food Science, Technische Universitat Berlin, Berlin, 10623, Germany. Electronic address: sebastian.isbanner@tu-berlin.de. FAU - Carins, Julia AU - Carins J AD - Social Marketing @ Griffith, Griffith University, 170 Kessels Road, Nathan, QLD, 4111, Australia. FAU - Babakhani, Nazila AU - Babakhani N AD - Social Marketing @ Griffith, Griffith University, 170 Kessels Road, Nathan, QLD, 4111, Australia. FAU - Kitunen, Anna AU - Kitunen A AD - Social Marketing @ Griffith, Griffith University, 170 Kessels Road, Nathan, QLD, 4111, Australia. LA - eng PT - Journal Article DEP - 20240926 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - *Diet, Healthy/psychology MH - Cross-Sectional Studies MH - Male MH - Female MH - Australia MH - *Motivation MH - Young Adult MH - Adult MH - *Feeding Behavior/psychology MH - *Health Behavior MH - Adolescent MH - Surveys and Questionnaires OTO - NOTNLM OT - Behaviour change OT - COM-B model OT - Healthy eating behaviours OT - Theoretical domains framework COIS- Declaration of competing interest We have no conflicts of interest to report and confirm that this submission is not published elsewhere or is currently under review. All authors accept full responsibility for all aspects of the work described, and the corresponding author can provide all original data for review. We look forward to receiving feedback from reviewers on this manuscript. EDAT- 2024/09/29 00:42 MHDA- 2024/11/06 00:22 CRDT- 2024/09/28 19:14 PHST- 2024/06/23 00:00 [received] PHST- 2024/09/24 00:00 [revised] PHST- 2024/09/25 00:00 [accepted] PHST- 2024/11/06 00:22 [medline] PHST- 2024/09/29 00:42 [pubmed] PHST- 2024/09/28 19:14 [entrez] AID - S0195-6663(24)00496-3 [pii] AID - 10.1016/j.appet.2024.107693 [doi] PST - ppublish SO - Appetite. 2024 Dec 1;203:107693. doi: 10.1016/j.appet.2024.107693. Epub 2024 Sep 26. PMID- 39340690 OWN - NLM STAT- MEDLINE DCOM- 20240928 LR - 20241001 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 29 IP - 1 DP - 2024 Sep 28 TI - Validation of the Chilean version of the Yale food addiction scale 2.0 in a non-clinical sample. PG - 62 LID - 10.1007/s40519-024-01691-3 [doi] LID - 62 AB - AIMS: The aim was to translate and culturally adapt the Yale Food Addiction Scale 2.0 (YFAS 2.0) to the Chilean population, evaluate its psychometric properties in a non-clinical sample, and assess the correlations between symptoms count of food addiction (FA) with demographic and anthropometric variables. METHODS AND PARTICIPANTS: We evaluated 301 participants (59.1% women) with a mean age of 29.7 +/- 12.4 years recruited from two universities and two businesses (non-clinical sample). The Chilean YFAS 2.0 was administered, and anthropometric measurements were carried out. The internal consistency of the items was estimated, and factor structure was tested by confirmatory factor analysis. Test-retest reliability was also examined. The correlations between symptoms count of FA and weight, waist circumference (WC), Body Mass Index (BMI), percentage of body fat (BF%), and lean mass were evaluated. RESULTS: The Chilean YFAS 2.0 presented good internal consistency, and confirmatory factor analysis supported the one-factor structure, in accordance with the original version. The ICC indicated excellent test-retest reliability. The prevalence of FA was 10.3%, and the symptom count of FA was 2.1 +/- 2.8. A small positive correlation between WC, BMI, and BF % and FA symptom count was found. CONCLUSION: The Chilean YFAS 2.0 may be a useful tool to investigate FA in Chile. Level of evidence Level V, cross-sectional descriptive study. CI - (c) 2024. The Author(s). FAU - Diaz-Torrente, Ximena AU - Diaz-Torrente X AD - Carrera de Nutricion y Dietetica, Facultad de Medicina, Universidad del Desarrollo, Santiago, Chile. xvdiaz@udd.cl. AD - Programa Doctorado en Nutricion y Alimentos, Universidad de Chile, Santiago, Chile. xvdiaz@udd.cl. FAU - Palacio, Ana AU - Palacio A AD - Carrera de Nutricion y Dietetica, Facultad de Medicina, Universidad del Desarrollo, Santiago, Chile. FAU - Valenzuela, Carina AU - Valenzuela C AD - Centro de Micro-Bioinnovacion (CMBi), Centro de Investigacion del Comportamiento Alimentario (CEIC), Escuela de Nutricion y Dietetica, Facultad de Farmacia, Universidad de Valparaiso, Valparaiso, Chile. FAU - Verges, Alvaro AU - Verges A AD - Escuela de Psicologia, Universidad de Los Andes, Santiago, Chile. FAU - Gearhardt, Ashley N AU - Gearhardt AN AD - Department of Psychology, University of Michigan, Ann Arbor, MI, USA. LA - eng GR - Scholarship Leading to Degree/Universidad del Desarrollo -Academic improvement program/ GR - 21211599/Agencia Nacional de Investigacion y Desarrollo/ PT - Journal Article PT - Validation Study DEP - 20240928 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - Female MH - Male MH - Chile MH - Adult MH - Reproducibility of Results MH - *Psychometrics MH - *Food Addiction/diagnosis/psychology MH - Young Adult MH - Middle Aged MH - Body Mass Index MH - Adolescent MH - Surveys and Questionnaires MH - Waist Circumference MH - Factor Analysis, Statistical MH - Cross-Sectional Studies PMC - PMC11438714 OTO - NOTNLM OT - Factor analysis OT - Food addiction OT - Validation OT - Yale food addiction scale 2.0 COIS- The authors declare no competing interests.The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results EDAT- 2024/09/28 22:44 MHDA- 2024/09/28 22:45 PMCR- 2024/09/28 CRDT- 2024/09/28 11:16 PHST- 2023/12/06 00:00 [received] PHST- 2024/09/04 00:00 [accepted] PHST- 2024/09/28 22:45 [medline] PHST- 2024/09/28 22:44 [pubmed] PHST- 2024/09/28 11:16 [entrez] PHST- 2024/09/28 00:00 [pmc-release] AID - 10.1007/s40519-024-01691-3 [pii] AID - 1691 [pii] AID - 10.1007/s40519-024-01691-3 [doi] PST - epublish SO - Eat Weight Disord. 2024 Sep 28;29(1):62. doi: 10.1007/s40519-024-01691-3. PMID- 39340227 OWN - NLM STAT- MEDLINE DCOM- 20241107 LR - 20260514 IS - 1520-6300 (Electronic) IS - 1042-0533 (Print) IS - 1042-0533 (Linking) VI - 36 IP - 11 DP - 2024 Nov TI - Calculation and Comparison of Step Guidelines for Preschooler Physical Activity While Indoors. PG - e24162 LID - 10.1002/ajhb.24162 [doi] AB - OBJECTIVES: Preschooler physical activity (PA) is vital for growth and development. The World Health Organization PA guidelines state preschoolers should achieve >/= 180 min/day of Total PA (TPA) of which >/= 60 min is moderate-to-vigorous PA (MVPA). A step/day recommendation to match these guidelines may be a more practical metric for caregivers to promote PA. The purpose of our investigation is to improve upon existing step recommendations by creating one for indoor-based activities, acknowledging where preschoolers spend most of their time, and various cut-points for PA. METHODS: In a laboratory study (Aim 1), a validated direct observation protocol was used to quantify preschooler PA intensity while performing indoor activities (n = 35). Actigraph GT3x accelerometers were placed on the waist, wrist, and ankle to measure step count. In a field study (Aim 2), habitual PA of 881 preschoolers (7113 valid days) via waist-worn accelerometers was used to assess the agreement between created guidelines (Aim 1) and other step recommendations with PA guidelines using Receiver Operating Characteristic and Area Under the Curve (ROC-AUC). RESULTS: In the laboratory study, calculated indoor step ranges were 6960-7440 (waist), 7200-8640 (wrist), and 7680-9120 (ankle) to align with existing PA guidance. In the field, the higher step guidelines (> 12 000) achieved very limited agreement, due to few preschoolers achieving this metric. The 6000 step/day guidelines had the highest agreement (AUCs: TPA: 0.637; MVPA: 0.751; TPA + MVPA: 0.761) with PA guideline. CONCLUSIONS: When preschoolers are indoors, 6000 steps may be the minimum for adequate PA. CI - (c) 2024 Wiley Periodicals LLC. FAU - Roman, Halle AU - Roman H AD - Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA. FAU - Redman, Leanne M AU - Redman LM AD - Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA. FAU - Neshteruk, Cody D AU - Neshteruk CD AD - Duke University School of Medicine, Durham, North Carolina, USA. AD - Duke Center for Childhood Obesity Research, Durham, North Carolina, USA. FAU - Hales, Derek AU - Hales D AD - University of North Carolina Center for Health Promotion and Disease Prevention, Chapel Hill, North Carolina, USA. FAU - Helsel, Brian AU - Helsel B AD - University of Kansas Medical Center, Kansas City, Kansas, USA. FAU - Kracht, Chelsea L AU - Kracht CL AUID- ORCID: 0000-0002-5467-0849 AD - Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA. AD - University of Kansas Medical Center, Kansas City, Kansas, USA. LA - eng GR - P20GM144269/NH/NIH HHS/United States GR - R21 HL170275/HL/NHLBI NIH HHS/United States GR - L40 HD109931/HD/NICHD NIH HHS/United States GR - P30 DK072476/DK/NIDDK NIH HHS/United States GR - T32 DK064584/DK/NIDDK NIH HHS/United States GR - U54 GM104940/GM/NIGMS NIH HHS/United States GR - R21HL170275/NH/NIH HHS/United States GR - P30DK072476/NH/NIH HHS/United States GR - K99HD107158/NH/NIH HHS/United States GR - T32DK064584/NH/NIH HHS/United States GR - U54GM104940/NH/NIH HHS/United States GR - K99 HD107158/HD/NICHD NIH HHS/United States GR - K01 AG083130/AG/NIA NIH HHS/United States GR - P20 GM144269/GM/NIGMS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20240928 PL - United States TA - Am J Hum Biol JT - American journal of human biology : the official journal of the Human Biology Council JID - 8915029 SB - IM MH - Humans MH - *Exercise MH - Child, Preschool MH - Female MH - Male MH - *Guidelines as Topic MH - Accelerometry/instrumentation/methods PMC - PMC11838103 MID - NIHMS2053246 OTO - NOTNLM OT - accelerometry OT - actigraphy OT - child health OT - guideline OT - physical activity OT - steps COIS- Conflicts of Interest The authors declare no conflicts of interest. EDAT- 2024/09/28 22:43 MHDA- 2024/11/07 06:23 PMCR- 2025/11/01 CRDT- 2024/09/28 04:33 PHST- 2024/09/18 00:00 [revised] PHST- 2024/07/17 00:00 [received] PHST- 2024/09/19 00:00 [accepted] PHST- 2024/11/07 06:23 [medline] PHST- 2024/09/28 22:43 [pubmed] PHST- 2024/09/28 04:33 [entrez] PHST- 2025/11/01 00:00 [pmc-release] AID - 10.1002/ajhb.24162 [doi] PST - ppublish SO - Am J Hum Biol. 2024 Nov;36(11):e24162. doi: 10.1002/ajhb.24162. Epub 2024 Sep 28. PMID- 39339722 OWN - NLM STAT- MEDLINE DCOM- 20240928 LR - 20240930 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 18 DP - 2024 Sep 16 TI - Maternal Folic Acid and Dietary Folate Intake in Relation to Sex Ratio at Birth and Sex-Specific Birth Weight in China. LID - 10.3390/nu16183122 [doi] LID - 3122 AB - BACKGROUND: It is well-established that prenatal folic acid supplements can reduce neural tube defects. However, the associations between folic acid supplementation, dietary folate intake, and overall folate intake with sex-specific birth outcomes are not yet fully understood. OBJECTIVES: This study aims to investigate the association of periconceptional folic acid supplement, dietary folate, and total folate intake with the sex ratio at birth and sex-specific birth weight. METHODS: Data were sourced from a cross-sectional survey conducted between August and December 2013 in Northwest China, involving 7318 infants and their mothers, recruited using a stratified multistage random sampling method. Folic acid supplements (400 mug/d) were ascertained via a retrospective in-person interview. Dietary folate was evaluated using a validated food frequency questionnaire. Birth outcomes, including sex and weight at birth, were obtained from the Medical Certificate of Birth. Generalized linear models were employed to calculate relative risks (RRs) or differences with 95% confidence intervals (CIs). RESULTS: No association or dose-response relationship was observed between folic acid supplement, dietary folate, and total folate intake during periconception and the likelihood of male births. However, women who took folic acid supplements during pre- and post-conception were associated with an increased male birth weight by 52.8 (8.1 to 97.5) g. Additionally, the total folate intake during periconception was associated with birth weight for males (upper vs. lower tertile: beta = 38.8, 95%CI: 5.0 to 72.5 g, p-trend = 0.024) and females (upper vs. lower tertile: beta = 42.4, 95%CI: 6.7 to 78.1; p-trend = 0.022). CONCLUSIONS: Our findings indicate that periconceptional total folate intake does not correlate with sex ratio at birth but was positively linked to infant birth weights, regardless of gender. These findings offer novel insights into potential benefits of total folate intake, beyond the prevention of neural tube defects, for policymakers and public health. FAU - Zhang, Binyan AU - Zhang B AUID- ORCID: 0000-0001-6307-9623 AD - School of Public Health, Xi'an Medical College, Xi'an 710021, China. AD - Department of Epidemiology and Health Statistics, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. FAU - Mi, Baibing AU - Mi B AUID- ORCID: 0000-0002-5208-7633 AD - Department of Epidemiology and Health Statistics, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. FAU - Dang, Shaonong AU - Dang S AUID- ORCID: 0000-0002-6980-8169 AD - Department of Epidemiology and Health Statistics, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. FAU - Yan, Hong AU - Yan H AD - Department of Epidemiology and Health Statistics, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. LA - eng PT - Journal Article DEP - 20240916 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 935E97BOY8 (Folic Acid) SB - IM MH - Humans MH - *Folic Acid/administration & dosage MH - Female MH - China/epidemiology MH - *Birth Weight MH - Male MH - *Dietary Supplements MH - *Sex Ratio MH - Pregnancy MH - Cross-Sectional Studies MH - Adult MH - Infant, Newborn MH - Maternal Nutritional Physiological Phenomena MH - Retrospective Studies MH - Diet/statistics & numerical data PMC - PMC11434778 OTO - NOTNLM OT - dietary folate OT - folic acid OT - sex ratio at birth OT - sex-specific birth weight COIS- The authors declared no conflicts of interest. EDAT- 2024/09/28 22:45 MHDA- 2024/09/28 22:46 PMCR- 2024/09/16 CRDT- 2024/09/28 01:29 PHST- 2024/08/24 00:00 [received] PHST- 2024/09/09 00:00 [revised] PHST- 2024/09/13 00:00 [accepted] PHST- 2024/09/28 22:46 [medline] PHST- 2024/09/28 22:45 [pubmed] PHST- 2024/09/28 01:29 [entrez] PHST- 2024/09/16 00:00 [pmc-release] AID - nu16183122 [pii] AID - nutrients-16-03122 [pii] AID - 10.3390/nu16183122 [doi] PST - epublish SO - Nutrients. 2024 Sep 16;16(18):3122. doi: 10.3390/nu16183122. PMID- 39339695 OWN - NLM STAT- MEDLINE DCOM- 20240928 LR - 20240930 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 18 DP - 2024 Sep 13 TI - Evaluation of Polyphenol Intake in Pregnant Women from South-Eastern Spain and the Effect on Anthropometric Measures at Birth and Gestational Age. LID - 10.3390/nu16183096 [doi] LID - 3096 AB - During pregnancy, controlling nutrition is crucial for the health of both mother and foetus. While polyphenols have positive health effects, some studies show harmful outcomes during pregnancy. This study evaluated polyphenol intake in a cohort of mother-child pairs and examined its effects on foetal anthropometric parameters. Polyphenol intake was assessed using food frequency questionnaires (FFQs) and 24-h dietary recalls, and analysed with the Phenol-Explorer database. Gestational age and birth measurements were retrieved from medical records. Statistical analyses validated dietary records and assessed polyphenol impact using multivariate generalised linear models. The study found that mean gestational age was 39.6 weeks, with a mean birth weight of 3.33 kg. Mean total polyphenol intake by FFQ was 2231 mg/day, slightly higher than 24-h recall data. Flavonoids and phenolic acids constituted 52% and 37% of intake, respectively, with fruits and legumes as primary sources. This study highlights the use of FFQs to estimate polyphenol intake. Furthermore, the study found associations between polyphenol consumption and anthropometric parameters at birth, with the effects varying depending on the type of polyphenol. However, a more precise evaluation of individual polyphenol intake is necessary to determine whether the effects they produce during pregnancy may be harmful or beneficial for foetal growth. FAU - Hinojosa-Nogueira, Daniel AU - Hinojosa-Nogueira D AUID- ORCID: 0000-0002-2604-3303 AD - Biomedical Research Center, Department of Nutrition and Bromatology, Institute of Nutrition and Food Technology, University of Granada, 18071 Granada, Spain. AD - Biosanitary Research Institute ibs.GRANADA, 18014 Granada, Spain. FAU - Romero-Molina, Desiree AU - Romero-Molina D AUID- ORCID: 0000-0001-6688-5401 AD - Biosanitary Research Institute ibs.GRANADA, 18014 Granada, Spain. AD - Statistics and Operations Research Department, Faculty of Sciences, University of Granada, 18071 Granada, Spain. FAU - Gonzalez-Alzaga, Beatriz AU - Gonzalez-Alzaga B AD - Biosanitary Research Institute ibs.GRANADA, 18014 Granada, Spain. AD - Andalusian School of Public Health (EASP), 18011 Granada, Spain. AD - CIBER of Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Gimenez-Asensio, Maria Jose AU - Gimenez-Asensio MJ AD - Biosanitary Research Institute ibs.GRANADA, 18014 Granada, Spain. FAU - Hernandez, Antonio F AU - Hernandez AF AUID- ORCID: 0000-0003-2983-5418 AD - Biosanitary Research Institute ibs.GRANADA, 18014 Granada, Spain. AD - CIBER of Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain. AD - Department of Legal Medicine and Toxicology, University of Granada, 18016 Granada, Spain. FAU - Navajas-Porras, Beatriz AU - Navajas-Porras B AUID- ORCID: 0000-0001-6211-5434 AD - Biomedical Research Center, Department of Nutrition and Bromatology, Institute of Nutrition and Food Technology, University of Granada, 18071 Granada, Spain. AD - Biosanitary Research Institute ibs.GRANADA, 18014 Granada, Spain. FAU - Delgado-Osorio, Adriana AU - Delgado-Osorio A AUID- ORCID: 0000-0001-6674-0085 AD - Biomedical Research Center, Department of Nutrition and Bromatology, Institute of Nutrition and Food Technology, University of Granada, 18071 Granada, Spain. AD - Biosanitary Research Institute ibs.GRANADA, 18014 Granada, Spain. FAU - Gomez-Martin, Antonio AU - Gomez-Martin A AUID- ORCID: 0000-0001-6537-1468 AD - Biosanitary Research Institute ibs.GRANADA, 18014 Granada, Spain. AD - Andalusian School of Public Health (EASP), 18011 Granada, Spain. FAU - Perez-Burillo, Sergio AU - Perez-Burillo S AUID- ORCID: 0000-0001-6398-7496 AD - Department of Pharmacology and Pediatrics, University of Malaga, 29010 Malaga, Spain. FAU - Pastoriza de la Cueva, Silvia AU - Pastoriza de la Cueva S AD - Biomedical Research Center, Department of Nutrition and Bromatology, Institute of Nutrition and Food Technology, University of Granada, 18071 Granada, Spain. FAU - Lacasana, Marina AU - Lacasana M AD - Biosanitary Research Institute ibs.GRANADA, 18014 Granada, Spain. AD - Andalusian School of Public Health (EASP), 18011 Granada, Spain. AD - CIBER of Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Rufian-Henares, Jose Angel AU - Rufian-Henares JA AUID- ORCID: 0000-0002-1428-4353 AD - Biomedical Research Center, Department of Nutrition and Bromatology, Institute of Nutrition and Food Technology, University of Granada, 18071 Granada, Spain. AD - Biosanitary Research Institute ibs.GRANADA, 18014 Granada, Spain. LA - eng GR - (PI13/01559),/Instituto de Salud Carlos III/ GR - (PI-045-2014)/Regional Health Council of Andalusia/ PT - Journal Article DEP - 20240913 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Polyphenols) RN - 0 (Flavonoids) RN - I3P9R8317T (phenolic acid) RN - 0 (Hydroxybenzoates) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Polyphenols/administration & dosage MH - *Birth Weight MH - Adult MH - Spain MH - *Gestational Age MH - *Anthropometry MH - Infant, Newborn MH - Maternal Nutritional Physiological Phenomena MH - Diet MH - Flavonoids/administration & dosage MH - Young Adult MH - Fetal Development/drug effects MH - Fruit MH - Diet Surveys MH - Hydroxybenzoates/analysis MH - Diet Records PMC - PMC11435302 OTO - NOTNLM OT - 24-h dietary recalls OT - foetal anthropometry OT - food frequency questionnaire OT - polyphenols OT - pregnant women COIS- The authors declare no conflicts of interest. EDAT- 2024/09/28 22:45 MHDA- 2024/09/28 22:46 PMCR- 2024/09/13 CRDT- 2024/09/28 01:29 PHST- 2024/08/13 00:00 [received] PHST- 2024/09/06 00:00 [revised] PHST- 2024/09/11 00:00 [accepted] PHST- 2024/09/28 22:46 [medline] PHST- 2024/09/28 22:45 [pubmed] PHST- 2024/09/28 01:29 [entrez] PHST- 2024/09/13 00:00 [pmc-release] AID - nu16183096 [pii] AID - nutrients-16-03096 [pii] AID - 10.3390/nu16183096 [doi] PST - epublish SO - Nutrients. 2024 Sep 13;16(18):3096. doi: 10.3390/nu16183096. PMID- 39339657 OWN - NLM STAT- MEDLINE DCOM- 20240928 LR - 20241007 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 18 DP - 2024 Sep 11 TI - Development of Spanish Nutrition Screening Tool for Hispanic Preschoolers. LID - 10.3390/nu16183058 [doi] LID - 3058 AB - Nutrition screening tools may facilitate early nutrition interventions specifically with Hispanic populations that are already at higher risk. There is a paucity of culturally competent and validated nutrition screening tools for 3-5-year-old Hispanic children. The purpose of this study was to develop a Spanish nutrition screening tool for 3-5-year-old children to be used by Spanish-speaking parents in community settings to appropriately address malnutrition risk factors with cultural sensitivity. All phases of the study were conducted in Spanish with native Spanish speakers. Face and content validity were established using focus groups, expert reviews, and pilot testing of the tool with Spanish-speaking parents. Parents of children 3-5 years old whose primary language was Spanish (n = 39) completed the nutrition screening, and a nutritionist completed an in-depth nutrition assessment of these children. Criterion validity was measured by comparing the results of the nutrition screening tool with the in-depth nutrition assessment. The nutrition screening tool had a sensitivity of 91.67% and a specificity of 81.48%. The negative predictive value was 69%, and the positive predictive value was 96%. The nutrition screening tool may be used to identify malnutrition in Hispanic children and needs further validation in larger samples. FAU - Arias, Denisse AU - Arias D AD - Nutrition, Dietetics, and Food Science Department, Brigham Young University, ESC S 221, Provo, UT 84602, USA. FAU - Lemmon, Elaine AU - Lemmon E AD - Nutrition, Dietetics, and Food Science Department, Brigham Young University, ESC S 221, Provo, UT 84602, USA. FAU - Martial, Marc-Aurel AU - Martial MA AUID- ORCID: 0000-0003-4916-4631 AD - College of Nursing, Brigham Young University, Provo, UT 84602, USA. FAU - Penaranda, Mariana AU - Penaranda M AD - Nutrition, Dietetics, and Food Science Department, Brigham Young University, ESC S 221, Provo, UT 84602, USA. FAU - Aguayo, Sandra AU - Aguayo S AD - Nutrition, Dietetics, and Food Science Department, Brigham Young University, ESC S 221, Provo, UT 84602, USA. FAU - Bellini, Sarah Gunnell AU - Bellini SG AD - Nutrition, Dietetics, and Food Science Department, Brigham Young University, ESC S 221, Provo, UT 84602, USA. LA - eng GR - Not applicable/Brigham Young University Myrtie Fulton Grant/ PT - Journal Article DEP - 20240911 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Hispanic or Latino MH - Child, Preschool MH - Female MH - Male MH - *Nutrition Assessment MH - *Mass Screening/methods MH - Nutritional Status MH - Reproducibility of Results MH - Parents MH - Child Nutrition Disorders/diagnosis/ethnology MH - Sensitivity and Specificity MH - Language PMC - PMC11435279 OTO - NOTNLM OT - Spanish OT - children OT - culture OT - malnutrition OT - nutrition screening OT - obesity OT - preschool OT - validation COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2024/09/28 22:44 MHDA- 2024/09/29 01:18 PMCR- 2024/09/11 CRDT- 2024/09/28 01:29 PHST- 2024/07/30 00:00 [received] PHST- 2024/09/02 00:00 [revised] PHST- 2024/09/07 00:00 [accepted] PHST- 2024/09/29 01:18 [medline] PHST- 2024/09/28 22:44 [pubmed] PHST- 2024/09/28 01:29 [entrez] PHST- 2024/09/11 00:00 [pmc-release] AID - nu16183058 [pii] AID - nutrients-16-03058 [pii] AID - 10.3390/nu16183058 [doi] PST - epublish SO - Nutrients. 2024 Sep 11;16(18):3058. doi: 10.3390/nu16183058. PMID- 39338048 OWN - NLM STAT- MEDLINE DCOM- 20240928 LR - 20260724 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 21 IP - 9 DP - 2024 Sep 2 TI - Prevalence of Polycystic Ovary Syndrome (PCOS) and Its Associated Risk Factors among Medical Students in Two Countries. LID - 10.3390/ijerph21091165 [doi] LID - 1165 AB - INTRODUCTION: PCOS, a common hormonal disorder in women of reproductive age, affects fertility and increases the risks of other diseases. Early detection, risk factor assessment, and intervention are crucial to prevent long-term complications. MATERIALS AND METHODS: This study was conducted using a pre-validated questionnaire at two medical colleges in the UAE and Oman. The first study (UAE) results are already published. Here, we present the findings of the second study (Oman) and compare them. RESULTS AND DISCUSSION: The prevalence of PCOS was 4.6% (n = 7) in Oman and 27.6% (n = 69) in the UAE using the NIH criteria. The most common symptoms were irregular periods, acne, and thinning of hair. Students showed acne as the most prevalent symptom of clinical hyperandrogenism. Omani students showed significantly more acne [70.1% (n = 108) vs. 41.6% (n = 104)], while Emirati students showed a higher prevalence of hirsutism [32% (n = 80) vs. 23.3% (n = 36)]. A higher number of students had irregular periods 30.8% (77/150) in the UAE, although the difference was not statistically significant. The prevalence of PCOS was significantly higher in Emirati medical students than in Omani students (p < 0.05). The prevalence was also lower among medical students in Oman compared to an unselected population, reported by a study that included all consecutive women between 12 and 45 years of age attending a hospital. An increased trend in unhealthy lifestyle practices was observed in the recent study. Obesity was a strong predictor of PCOS symptoms across the populations in both countries (p < 0.05). CONCLUSION: The prevalence of PCOS and clinical signs of hyperandrogenism vary significantly between countries in the MENA region. There is a need to identify specific risk factors associated with PCOS in different populations, explore the genetic basis, and undertake collaborative efforts among healthcare professionals from various disciplines to raise awareness about PCOS and its associated risks. FAU - Begum, Gulam Saidunnisa AU - Begum GS AD - Department of Biochemistry, College of Medicine and Health Sciences, National University of Science and Technology, Al Tareef, Sohar 321, Oman. FAU - Almashaikhi, Noor Alhuda Talal AU - Almashaikhi NAT AD - College of Medicine and Health Sciences, National University of Science and Technology, Al Tareef, Sohar 321, Oman. FAU - Albalushi, Maryam Yousuf AU - Albalushi MY AUID- ORCID: 0009-0008-3196-9507 AD - College of Medicine and Health Sciences, National University of Science and Technology, Al Tareef, Sohar 321, Oman. FAU - Alsalehi, Hajar Mohammed AU - Alsalehi HM AUID- ORCID: 0009-0004-0334-878X AD - College of Medicine and Health Sciences, National University of Science and Technology, Al Tareef, Sohar 321, Oman. FAU - Alazawi, Rayan Salih AU - Alazawi RS AUID- ORCID: 0009-0002-6035-5260 AD - College of Medicine and Health Sciences, National University of Science and Technology, Al Tareef, Sohar 321, Oman. FAU - Goud, Bellary Kuruba Manjunatha AU - Goud BKM AUID- ORCID: 0000-0002-7195-6945 AD - Department of Biochemistry, RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah P.O. Box-11172, United Arab Emirates. FAU - Dube, Rajani AU - Dube R AUID- ORCID: 0000-0002-1539-6162 AD - Department of Obstetrics and Gynecology, RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah P.O. Box-11172, United Arab Emirates. LA - eng PT - Journal Article DEP - 20240902 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - *Polycystic Ovary Syndrome/epidemiology MH - Humans MH - Female MH - *Students, Medical/statistics & numerical data MH - Oman/epidemiology MH - Prevalence MH - Risk Factors MH - United Arab Emirates/epidemiology MH - Young Adult MH - Adult MH - Adolescent MH - Surveys and Questionnaires PMC - PMC11430840 OTO - NOTNLM OT - PCOS in medical students OT - complications OT - obesity and PCOS OT - polycystic vary syndrome OT - risk factors of PCOS COIS- The authors declare no conflicts of interest. EDAT- 2024/09/28 22:45 MHDA- 2024/09/29 01:18 PMCR- 2024/09/02 CRDT- 2024/09/28 01:20 PHST- 2024/06/26 00:00 [received] PHST- 2024/08/21 00:00 [revised] PHST- 2024/08/22 00:00 [accepted] PHST- 2024/09/29 01:18 [medline] PHST- 2024/09/28 22:45 [pubmed] PHST- 2024/09/28 01:20 [entrez] PHST- 2024/09/02 00:00 [pmc-release] AID - ijerph21091165 [pii] AID - ijerph-21-01165 [pii] AID - 10.3390/ijerph21091165 [doi] PST - epublish SO - Int J Environ Res Public Health. 2024 Sep 2;21(9):1165. doi: 10.3390/ijerph21091165. PMID- 39337215 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240930 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 12 IP - 18 DP - 2024 Sep 19 TI - Perinatal Exposure to Tobacco Smoke and Its Association with the Maternal and Offspring Microbiome: A Systematic Review. LID - 10.3390/healthcare12181874 [doi] LID - 1874 AB - BACKGROUND: The human microbiome, comprising trillions of microorganisms, significantly influences human health and disease. During critical periods like the perinatal phase, the microbiome undergoes significant changes, impacting lifelong health. Tobacco smoke, a known environmental pollutant, has adverse effects on health, particularly during pregnancy. Despite this, its association with the perinatal microbiome remains understudied. METHODS: We conducted a systematic review to integrate findings on perinatal tobacco smoke exposure and its association with the maternal and neonatal microbiomes. We conducted a comprehensive literature search in the PubMed, Scopus, and Web of Science databases from January 2000 to February 2024. We selected studies that met predefined inclusion criteria and performed data extraction. RESULTS: The review included eight studies that revealed diverse associations of perinatal tobacco exposure with the maternal and neonatal microbiome. Active smoking during pregnancy was linked to alterations in microbiome composition and diversity in children. Maternal smoking correlated with increased Firmicutes abundance and decreased Akkermansia muciniphila abundance in offspring. Additionally, exposure to thirdhand smoke in neonatal intensive care units was related to infant microbiome diversity. Infants exposed to tobacco smoke showed various microbial changes, suggesting potential implications for childhood health outcomes, including obesity risk. CONCLUSIONS: Perinatal exposure to tobacco smoke exerts significant influence on the maternal and neonatal microbiomes, with potential implications for long-term health outcomes. Addressing socioeconomic and psychological barriers to smoking cessation, implementing stricter smoking regulations, and promoting public health campaigns are essential steps towards reducing tobacco-related harm during the perinatal period. Further longitudinal studies and standardized assessment methods are needed to validate these findings and guide the development of effective preventive measures. FAU - Falara, Eleni AU - Falara E AUID- ORCID: 0009-0003-0643-5400 AD - Department of Midwifery, Faculty of Health and Caring Sciences, University of West Attica, 12243 Egaleo, Greece. FAU - Metallinou, Dimitra AU - Metallinou D AUID- ORCID: 0000-0003-1788-3818 AD - Department of Midwifery, Faculty of Health and Caring Sciences, University of West Attica, 12243 Egaleo, Greece. FAU - Nanou, Christina AU - Nanou C AD - Department of Midwifery, Faculty of Health and Caring Sciences, University of West Attica, 12243 Egaleo, Greece. FAU - Vlachou, Maria AU - Vlachou M AD - Department of Midwifery, Faculty of Health and Caring Sciences, University of West Attica, 12243 Egaleo, Greece. FAU - Diamanti, Athina AU - Diamanti A AD - Department of Midwifery, Faculty of Health and Caring Sciences, University of West Attica, 12243 Egaleo, Greece. LA - eng GR - The APC was partially funded by the "Special Account for Research Grants" of the University of West Attica, Athens, Greece./The APC was partially funded by the "Special Account for Research Grants" of the University of West Attica, Athens, Greece./ PT - Journal Article PT - Review DEP - 20240919 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC11431162 OTO - NOTNLM OT - microbiome OT - microbiota OT - offspring OT - perinatal period OT - pregnancy OT - smoking OT - tobacco smoke COIS- The authors declare no conflicts of interest. EDAT- 2024/09/28 22:44 MHDA- 2024/09/28 22:45 PMCR- 2024/09/19 CRDT- 2024/09/28 01:15 PHST- 2024/06/30 00:00 [received] PHST- 2024/09/11 00:00 [revised] PHST- 2024/09/12 00:00 [accepted] PHST- 2024/09/28 22:45 [medline] PHST- 2024/09/28 22:44 [pubmed] PHST- 2024/09/28 01:15 [entrez] PHST- 2024/09/19 00:00 [pmc-release] AID - healthcare12181874 [pii] AID - healthcare-12-01874 [pii] AID - 10.3390/healthcare12181874 [doi] PST - epublish SO - Healthcare (Basel). 2024 Sep 19;12(18):1874. doi: 10.3390/healthcare12181874. PMID- 39334677 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240930 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 11 IP - 9 DP - 2024 Sep 21 TI - BMI, Dental Caries, and Risk Factors among Elementary School Children: A Cross-Sectional Study. LID - 10.3390/children11091145 [doi] LID - 1145 AB - Background/Objectives: Obesity and dental caries are multifactorial diseases with high prevalence amongst Saudi children. The aim of the study was to determine their association with common risk factors. Methods: This cross-sectional study examined 300 children attending elementary schools. After taking their height and weight, their body mass indices (BMIs) were calculated. Oral examination was performed to record the decayed, missed, and filled scores (dmft/DMFT). A thorough questionnaire was compiled and validated to gather information on diet and physical activity (PA). The KIDMED score was calculated from a 16-item questionnaire to assess diet. Junk food and PA scores were also calculated based on relevant questions. Nonparametric tests were used to assess the associations between the scores and health outcomes (dmft/DMFT and BMI). Results: Fifty-eight of the children had poor diets, which was associated with higher dmft/DMFT (p = 0.012). PA levels were very low, and the average PA score was 2.12 +/- 0.61. No association was found between BMI percentiles and PA level, nor between BMI percentiles and diet quality. Older children had lower BMI percentiles compared with younger children (coefficient = -9.35, 95% CI: -17.05, -1.65), and a borderline significant negative association was observed between dmft/DMFT and BMI percentile. Conclusions: Poor diets and chips consumption were related to dental caries. Obesity was not related to diet quality nor PA level. FAU - Farsi, Deema J AU - Farsi DJ AUID- ORCID: 0000-0003-1371-913X AD - Department of Pediatric Dentistry, Faculty of Dentistry, Kind Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia. LA - eng GR - (G: 553-165-1441)/King Abdulaziz University/ PT - Journal Article DEP - 20240921 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC11430253 OTO - NOTNLM OT - BMI OT - KIDMED OT - child OT - dental caries OT - diet OT - obesity OT - physical activity COIS- The study was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/09/28 22:44 MHDA- 2024/09/28 22:45 PMCR- 2024/09/21 CRDT- 2024/09/28 01:02 PHST- 2024/09/03 00:00 [received] PHST- 2024/09/12 00:00 [revised] PHST- 2024/09/21 00:00 [accepted] PHST- 2024/09/28 22:45 [medline] PHST- 2024/09/28 22:44 [pubmed] PHST- 2024/09/28 01:02 [entrez] PHST- 2024/09/21 00:00 [pmc-release] AID - children11091145 [pii] AID - children-11-01145 [pii] AID - 10.3390/children11091145 [doi] PST - epublish SO - Children (Basel). 2024 Sep 21;11(9):1145. doi: 10.3390/children11091145. PMID- 39334259 OWN - NLM STAT- MEDLINE DCOM- 20240928 LR - 20241001 IS - 1472-6963 (Electronic) IS - 1472-6963 (Linking) VI - 24 IP - 1 DP - 2024 Sep 27 TI - Development and validation of the Health Activation Scale for Children (HAS-C): an important intermediate outcome measure for health promotion initiatives. PG - 1120 LID - 10.1186/s12913-024-11526-7 [doi] LID - 1120 AB - BACKGROUND: Valid and reliable measures for assessing health activation in school-aged children are currently lacking. This study aimed to develop a scale to measure health activation and evaluate its psychometric properties among English-speaking primary school children in Singapore. METHODS: The development of the Health Activation Scale for Children (HAS-C) involved an extensive literature review, expert consultations, cognitive interviews with primary school children, and thorough discussions for dimension and item refinement. A cross-sectional study was conducted with 597 children aged 8 to 12 years, recruited from four mainstream primary schools, comprising 50.1% boys and 64.8% Chinese students. The potential scale, along with other measures, was independently completed by the children. Descriptive statistics were provided for individual scale items. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were performed to assess factorial validity. Convergent validity was examined by correlating the scale scores with scores of health confidence and self-efficacy measures. Hypothesis-testing validity was evaluated by assessing the scale's correlation with self-reported health behaviours, including daily consumption of vegetables and fruits, time spent on sedentary activities and physical activities. Internal consistency reliability was measured using Cronbach's alpha. RESULTS: EFA suggested a three-factor structure for the 12-item HAS-C, which was subsequently confirmed by CFA with a good model fit. All three HAS-C dimension scores demonstrated moderate correlations (rho = 0.34-0.52) with health confidence and self-efficacy measures, indicating good convergent validity. They were positively correlated with more vegetable and fruit intakes, more time spent on exercises, and negatively correlated with time spent on sedentary activities, supporting hypothesis-testing validity. Internal consistency reliability for individual HAS-C dimensions was generally acceptable, with Cronbach's alpha values of 0.70 or above. CONCLUSION: The 12-item multi-dimensional HAS-C exhibited good validity and reliability, making it a valuable tool for assessing health activation in primary school-aged children. CI - (c) 2024. The Author(s). FAU - Ge, Lixia AU - Ge L AUID- ORCID: 0000-0001-8080-7020 AD - Health Services & Outcomes Research, National Healthcare Group, Annex@National Skin Centre Level 4, 1 Mandalay Road, Singapore, 308205, Singapore. lixia_ge@nhg.com.sg. FAU - Molina, Joseph AU - Molina J AD - Health Services & Outcomes Research, National Healthcare Group, Annex@National Skin Centre Level 4, 1 Mandalay Road, Singapore, 308205, Singapore. FAU - Karthigayan, Ramakrishnan AU - Karthigayan R AD - Community Care Division, Population Health Campus, National Healthcare Group, #03-08 Nexus @ One-north, 3 Fusionopolis Link, Singapore, 138543, Singapore. FAU - Foo, Hui Ting AU - Foo HT AD - Community Care Division, Population Health Campus, National Healthcare Group, #03-08 Nexus @ One-north, 3 Fusionopolis Link, Singapore, 138543, Singapore. FAU - Tang, Marcus AU - Tang M AD - Community Care Division, Population Health Campus, National Healthcare Group, #03-08 Nexus @ One-north, 3 Fusionopolis Link, Singapore, 138543, Singapore. FAU - Chua, Rochelle AU - Chua R AD - Community Care Division, Population Health Campus, National Healthcare Group, #03-08 Nexus @ One-north, 3 Fusionopolis Link, Singapore, 138543, Singapore. FAU - Ong, Chin Fung AU - Ong CF AD - Community Care Division, Population Health Campus, National Healthcare Group, #03-08 Nexus @ One-north, 3 Fusionopolis Link, Singapore, 138543, Singapore. LA - eng PT - Journal Article PT - Validation Study DEP - 20240927 PL - England TA - BMC Health Serv Res JT - BMC health services research JID - 101088677 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - *Psychometrics MH - *Health Promotion/methods MH - Cross-Sectional Studies MH - Singapore MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - Health Behavior MH - Factor Analysis, Statistical MH - Outcome Assessment, Health Care PMC - PMC11430336 OTO - NOTNLM OT - Children OT - Development OT - Health activation OT - Psychometric properties OT - Validation COIS- The authors declare no competing interests. EDAT- 2024/09/28 22:45 MHDA- 2024/09/28 22:46 PMCR- 2024/09/27 CRDT- 2024/09/28 00:25 PHST- 2024/01/19 00:00 [received] PHST- 2024/09/02 00:00 [accepted] PHST- 2024/09/28 22:46 [medline] PHST- 2024/09/28 22:45 [pubmed] PHST- 2024/09/28 00:25 [entrez] PHST- 2024/09/27 00:00 [pmc-release] AID - 10.1186/s12913-024-11526-7 [pii] AID - 11526 [pii] AID - 10.1186/s12913-024-11526-7 [doi] PST - epublish SO - BMC Health Serv Res. 2024 Sep 27;24(1):1120. doi: 10.1186/s12913-024-11526-7. PMID- 39333484 OWN - NLM STAT- MEDLINE DCOM- 20240927 LR - 20241004 IS - 2044-4052 (Electronic) IS - 2044-4052 (Linking) VI - 14 IP - 1 DP - 2024 Sep 27 TI - The association of dietary total antioxidant capacity and gestational diabetes: a prospective cohort study from the Mothers and their children's health (MATCH). PG - 78 LID - 10.1038/s41387-024-00333-y [doi] LID - 78 AB - BACKGROUND/OBJECTIVES: There is evidence to support the hypothesis that a diet rich in antioxidants can help safeguard against the development of gestational diabetes mellitus (GDM). This study aimed to investigate the association between dietary total antioxidant capacity (DTAC) during early pregnancy and the risk of GDM. SUBJECTS/METHODS: We included 1856 pregnant women in their first trimester from the Mothers and their Children's Health (MATCH) prospective cohort study. Prepregnancy dietary intake was assessed using a validated food frequency questionnaire (FFQ) and was used to calculate the DTAC score. Incident GDM was diagnosed based on the American Diabetes Association criteria. We estimated the association between DTAC and GDM using propensity score-based inverse probability weighting (IPW). RESULTS: Overall, 369 (14.6%) of the pregnant women were identified with GDM. The mean DTAC score and the corresponding standard deviation (SD) was 2.82+/- (2.56) mmol/100 g, with a range of 0.01 to 18.55. The adjusted risk of GDM decreased by 34% (95% CI = 10%, 52%, p = 0.023) for each DTAC score increase. The results showed that women in the highest quartile of DTAC had a lower risk of developing GDM compared to those in the lowest quartile (adjusted RR: 0.29, 95% CI: 0.12, 0.68, p = 0.005). CONCLUSION: DTAC in early pregnancy is significantly associated with a lower risk of GDM. Additional larger cohort studies are needed to validate these findings. CI - (c) 2024. The Author(s). FAU - Heshmati, Shilan AU - Heshmati S AUID- ORCID: 0000-0003-4287-8455 AD - Department of Nutritional Science, School of Nutritional Science and Food Technology, Kermanshah University of Medical Science, Kermanshah, Iran. FAU - Moludi, Jalal AU - Moludi J AD - Department of Nutritional Science, School of Nutritional Science and Food Technology, Kermanshah University of Medical Science, Kermanshah, Iran. FAU - Nachvak, Seyed Mostafa AU - Nachvak SM AD - Department of Nutritional Science, School of Nutritional Science and Food Technology, Kermanshah University of Medical Science, Kermanshah, Iran. smnachvak@hotmail.com. FAU - Pirjani, Reihaneh AU - Pirjani R AD - Department of Obstetrics and Gynecology, Arash Women's Hospital, Tehran University of Medical sciences, Tehran, Iran. FAU - Heshmati, Javad AU - Heshmati J AUID- ORCID: 0000-0002-2676-0185 AD - University of Ottawa Heart Institute, University of Ottawa, Ottawa, Canada. FAU - Sepidarkish, Mahdi AU - Sepidarkish M AUID- ORCID: 0000-0003-4732-6684 AD - Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. mahdi.sepidarkish@gmail.com. AD - Department of Biostatistics and Epidemiology, School of Public Health, Babol University of Medical Sciences, Babol, Iran. mahdi.sepidarkish@gmail.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240927 PL - England TA - Nutr Diabetes JT - Nutrition & diabetes JID - 101566341 RN - 0 (Antioxidants) SB - IM MH - Humans MH - Female MH - *Diabetes, Gestational/epidemiology MH - Pregnancy MH - Prospective Studies MH - Adult MH - *Antioxidants/administration & dosage/analysis MH - *Diet MH - Pregnancy Trimester, First MH - Risk Factors MH - Cohort Studies PMC - PMC11437067 COIS- The authors declare no competing interests. EDAT- 2024/09/28 09:43 MHDA- 2024/09/28 09:44 PMCR- 2024/09/27 CRDT- 2024/09/27 23:42 PHST- 2023/10/26 00:00 [received] PHST- 2024/09/02 00:00 [accepted] PHST- 2024/08/14 00:00 [revised] PHST- 2024/09/28 09:44 [medline] PHST- 2024/09/28 09:43 [pubmed] PHST- 2024/09/27 23:42 [entrez] PHST- 2024/09/27 00:00 [pmc-release] AID - 10.1038/s41387-024-00333-y [pii] AID - 333 [pii] AID - 10.1038/s41387-024-00333-y [doi] PST - epublish SO - Nutr Diabetes. 2024 Sep 27;14(1):78. doi: 10.1038/s41387-024-00333-y. PMID- 39332769 OWN - NLM STAT- MEDLINE DCOM- 20241108 LR - 20260923 IS - 1541-6100 (Electronic) IS - 0022-3166 (Print) IS - 0022-3166 (Linking) VI - 154 IP - 11 DP - 2024 Nov TI - Identification and Replication of Urine Metabolites Associated With Short-Term and Habitual Intake of Sweet and Fatty Snacks in European Children and Adolescents. PG - 3274-3285 LID - S0022-3166(24)01043-5 [pii] LID - 10.1016/j.tjnut.2024.09.026 [doi] AB - BACKGROUND: Intake of sweet and fatty snacks may partly contribute to the occurrence of obesity and other health conditions in childhood. Traditional dietary assessment methods may be limited in accurately assessing the intake of sweet and fatty snacks in children. Metabolite biomarkers may aid the objective assessment of children's food intake and support establishing diet-disease relationships. OBJECTIVES: The present study aimed to identify biomarkers of sweet and fatty snack intake in 2 independent cohorts of European children. METHODS: We used data from the IDEFICS/I.Family cohort from baseline (2007/2008) and 2 follow-up examination waves (2009/2010 and 2013/2014). In total, 1788 urine samples from 599 children were analyzed for untargeted metabolomics using high-resolution liquid chromatography-mass spectrometry. Short-term dietary intake was assessed by 24-h dietary recalls, and habitual dietary intake was calculated with the National Cancer Institute method. Data from the Dortmund Nutritional and Anthropometric Longitudinal Designed (DONALD) cohort of 24-h urine samples (n = 567) and 3-d weighted dietary records were used for external replication of results. Multivariate modeling with unbiased variable selection in R algorithms and linear mixed models were used to identify novel biomarkers. Metabolite features significantly associated with dietary intake were then annotated. RESULTS: In total, 66 metabolites were discovered and found to be statistically significant for chocolate candy; cakes, puddings, and cookies; candy and sweets; ice cream; and crisps. Most of the features (n = 62) could not be annotated. Short-term and habitual chocolate intake were positively associated with theobromine, xanthosine, and cyclo(L-prolyl-L-valyl). These results were replicated in the DONALD cohort. Short-term candy and sweet intake was negatively associated with octenoylcarnitine. CONCLUSIONS: Of the potential metabolite biomarkers of sweet and fatty snacks in children, 3 biomarkers of chocolate intake, namely theobromine, xanthosine, and cyclo(L-prolyl-L-valyl), are externally replicated. However, these potential biomarkers require further validation in children. CI - Copyright (c) 2024 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Goerdten, Jantje AU - Goerdten J AD - Leibniz Institute for Prevention Research and Epidemiology (BIPS), Bremen, Germany. Electronic address: goerdten@leibniz-bips.de. FAU - Muli, Samuel AU - Muli S AD - Unit of Nutritional Epidemiology, Department of Nutrition and Food Sciences, University of Bonn, Bonn, Germany. FAU - Rattner, Jodi AU - Rattner J AD - International Agency for Research on Cancer (IARC), Lyon, France. FAU - Merdas, Mira AU - Merdas M AD - International Agency for Research on Cancer (IARC), Lyon, France. FAU - Achaintre, David AU - Achaintre D AD - International Agency for Research on Cancer (IARC), Lyon, France. FAU - Yuan, Li AU - Yuan L AD - Leibniz Institute for Prevention Research and Epidemiology (BIPS), Bremen, Germany. FAU - De Henauw, Stefaan AU - De Henauw S AD - Department of Public Health and Primary Care, Ghent University, Ghent, Belgium. FAU - Foraita, Ronja AU - Foraita R AD - Leibniz Institute for Prevention Research and Epidemiology (BIPS), Bremen, Germany. FAU - Hunsberger, Monica AU - Hunsberger M AD - School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Huybrechts, Inge AU - Huybrechts I AD - International Agency for Research on Cancer (IARC), Lyon, France. FAU - Lissner, Lauren AU - Lissner L AD - School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Molnar, Denes AU - Molnar D AD - Department of Pediatrics, Medical School, University of Pecs, Pecs, Hungary. FAU - Moreno, Luis A AU - Moreno LA AD - GENUD (Growth, Exercise, NUtrition and Development) Research Group, Faculty of Health Sciences, University of Zaragoza, Instituto Agroalimentario de Aragon (IA2) and Instituto de Investigacion Sanitaria Aragon (IIS Aragon), Zaragoza, Spain; Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. FAU - Russo, Paola AU - Russo P AD - Institute of Food Sciences, CNR, Avellino, Italy. FAU - Veidebaum, Toomas AU - Veidebaum T AD - National Institute for Health Development, Tallinn, Estonia. FAU - Aleksandrova, Krasimira AU - Aleksandrova K AD - Leibniz Institute for Prevention Research and Epidemiology (BIPS), Bremen, Germany; Faculty of Human and Health Sciences, University of Bremen, Bremen, Germany. FAU - Nothlings, Ute AU - Nothlings U AD - Unit of Nutritional Epidemiology, Department of Nutrition and Food Sciences, University of Bonn, Bonn, Germany. FAU - Oluwagbemigun, Kolade AU - Oluwagbemigun K AD - Unit of Nutritional Epidemiology, Department of Nutrition and Food Sciences, University of Bonn, Bonn, Germany. FAU - Keski-Rahkonen, Pekka AU - Keski-Rahkonen P AD - International Agency for Research on Cancer (IARC), Lyon, France. FAU - Floegel, Anna AU - Floegel A AD - Leibniz Institute for Prevention Research and Epidemiology (BIPS), Bremen, Germany; Section of Dietetics, Faculty of Agriculture and Food Sciences, Hochschule Neubrandenburg-University of Applied Sciences, Neubrandenburg, Germany. LA - eng GR - 001/WHO_/World Health Organization/International PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240925 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 RN - 0 (Biomarkers) RN - 0 (Dietary Fats) SB - IM MH - Humans MH - Child MH - Male MH - Female MH - *Snacks MH - *Biomarkers/urine MH - Adolescent MH - Europe MH - Cohort Studies MH - Feeding Behavior MH - Diet MH - Dietary Fats/administration & dosage MH - Metabolomics/methods PMC - PMC11600116 OTO - NOTNLM OT - biomarker identification OT - children and adolescents OT - metabolite biomarkers of food intake OT - sweet and fatty snacks OT - untargeted metabolomics COIS- Conflict of interest AF reports financial support was provided by German Research Foundation. PK-R reports financial support was provided by French National Research Agency. All other authors report no conflicts of interest. EDAT- 2024/09/28 09:46 MHDA- 2024/11/13 13:57 PMCR- 2024/09/25 CRDT- 2024/09/27 19:21 PHST- 2024/04/26 00:00 [received] PHST- 2024/09/19 00:00 [revised] PHST- 2024/09/23 00:00 [accepted] PHST- 2024/11/13 13:57 [medline] PHST- 2024/09/28 09:46 [pubmed] PHST- 2024/09/27 19:21 [entrez] PHST- 2024/09/25 00:00 [pmc-release] AID - S0022-3166(24)01043-5 [pii] AID - 10.1016/j.tjnut.2024.09.026 [doi] PST - ppublish SO - J Nutr. 2024 Nov;154(11):3274-3285. doi: 10.1016/j.tjnut.2024.09.026. Epub 2024 Sep 25. PMID- 39332136 OWN - NLM STAT- MEDLINE DCOM- 20241003 LR - 20260813 IS - 1873-3360 (Electronic) IS - 0306-4530 (Print) IS - 0306-4530 (Linking) VI - 170 DP - 2024 Dec TI - Associations between adolescent perceived loneliness and hair cortisol concentration. PG - 107184 LID - S0306-4530(24)00229-4 [pii] LID - 10.1016/j.psyneuen.2024.107184 [doi] AB - INTRODUCTION: Adolescents experience high levels of loneliness, which is linked to poor health in adulthood. Loneliness may contribute to poor health through chronic dysregulation of the hypothalamic-pituitary-adrenal axis. In this analysis, we examined the associations between survey- and ecological momentary assessment (EMA)-based measures of loneliness and hair cortisol concentrations (HCC) in a sample of 1102 adolescents and assessed sex differences in this relationship. METHODS: Data came from wave 1 of the Adolescent Health and Development in Context study. We conducted a series of multivariable linear regression models to examine the associations between loneliness and HCC. Models were adjusted for adolescent and caregiver demographics, adolescent clinical factors, adolescent hair care practices, and adolescent lifetime mental health diagnosis and current psychotropic medication use. An interaction term between sex and loneliness was added to assess for effect moderation. RESULTS: In our sample, the mean HCC was 1.35 pg/mg (SD=1.1). The mean for the unstandardized survey loneliness measure was 1.79 (SD=0.79) for the total analytic sample. The unstandardized mean for the EMA loneliness measure was - 0.02 (SD=2.1) for the total analytic sample. In model one testing the bivariate linear relationship between loneliness and HCC, higher loneliness via survey and EMA measures was associated with lower HCC (Survey: b= - 0.10, SE=0.03, p=.004; EMA: b= - 0.09, SE=0.03, p=.005). In model two, higher loneliness remained significantly associated with lower HCC (Survey: b= - 0.07, SE=0.03, p=.023; EMA: b= - 0.07, SE=0.03, p=.037), after controlling for the following covariates: sociodemographic factors, pubertal development and BMI, corticosteroid use, hair care practices, season of collection and assayed hair length. In model 3, youth lifetime mental health diagnosis and current psychotropic medication use were added into the regression model, and higher loneliness remained significantly associated with lower HCC (Survey: b= - 0.07, SE=0.03, p=.029; EMA: b= - 0.07, SE=0.03, p=.039). There was no effect modification by sex (Survey: b=0.04, SE=0.06, p=.552; EMA: b= - 0.01, SE=0.06, p=.843). CONCLUSIONS: In our analysis, both survey- and EMA-reported loneliness measures were associated with lower HCC. No evidence of an interaction between sex and loneliness was observed. Future research is needed to validate these findings and investigate longitudinal relationships among adolescent loneliness, stress physiology, and downstream health sequelae. CI - Copyright (c) 2024 Elsevier Ltd. All rights reserved. FAU - Anderson, Avery M AU - Anderson AM AD - University of Colorado College of Nursing, Aurora, CO, USA. Electronic address: avery.m.anderson@cuanschutz.edu. FAU - Sherman, Jessica AU - Sherman J AD - The Ohio State University College of Nursing, Columbus, OH, USA. FAU - Fitzpatrick, Margaret M AU - Fitzpatrick MM AD - The Ohio State University College of Nursing, Columbus, OH, USA. FAU - Browning, Christopher AU - Browning C AD - The Ohio State University Department of Sociology, Columbus, OH, USA. FAU - Kertes, Darlene A AU - Kertes DA AD - University of Florida Department of Psychology, Gainesville, FL, USA. FAU - Mackos, Amy AU - Mackos A AD - The Ohio State University College of Nursing, Columbus, OH, USA. FAU - Pickler, Rita H AU - Pickler RH AD - The Ohio State University College of Nursing, Columbus, OH, USA. FAU - Smith, Lindsay AU - Smith L AD - The Ohio State University College of Nursing, Columbus, OH, USA. FAU - Ford, Jodi L AU - Ford JL AD - The Ohio State University College of Nursing, Columbus, OH, USA. LA - eng GR - R01 DA032371/DA/NIDA NIH HHS/United States GR - P2C HD058484/HD/NICHD NIH HHS/United States GR - R01 NR019008/NR/NINR NIH HHS/United States GR - R21 DA034960/DA/NIDA NIH HHS/United States GR - T32 NR014225/NR/NINR NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20240916 PL - England TA - Psychoneuroendocrinology JT - Psychoneuroendocrinology JID - 7612148 RN - WI4X0X7BPJ (Hydrocortisone) SB - IM MH - Humans MH - Female MH - Male MH - Adolescent MH - *Loneliness/psychology MH - *Hydrocortisone/metabolism/analysis MH - *Hair/chemistry MH - Hypothalamo-Hypophyseal System/metabolism MH - Pituitary-Adrenal System/metabolism MH - Sex Factors PMC - PMC12978286 MID - NIHMS2048809 OTO - NOTNLM OT - Adolescence OT - Cortisol OT - HPA-axis OT - Loneliness OT - Stress physiology COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/09/28 09:46 MHDA- 2024/10/04 00:42 PMCR- 2026/03/11 CRDT- 2024/09/27 18:04 PHST- 2024/05/22 00:00 [received] PHST- 2024/09/13 00:00 [revised] PHST- 2024/09/13 00:00 [accepted] PHST- 2024/10/04 00:42 [medline] PHST- 2024/09/28 09:46 [pubmed] PHST- 2024/09/27 18:04 [entrez] PHST- 2026/03/11 00:00 [pmc-release] AID - S0306-4530(24)00229-4 [pii] AID - 10.1016/j.psyneuen.2024.107184 [doi] PST - ppublish SO - Psychoneuroendocrinology. 2024 Dec;170:107184. doi: 10.1016/j.psyneuen.2024.107184. Epub 2024 Sep 16. PMID- 39331937 OWN - NLM STAT- MEDLINE DCOM- 20240927 LR - 20250503 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 103 IP - 39 DP - 2024 Sep 27 TI - Nutrition literacy and eating habits in children from food-secure versus food-insecure households: A cross-sectional study. PG - e39812 LID - 10.1097/MD.0000000000039812 [doi] LID - e39812 AB - This study aimed to explore whether maternal food and nutrition literacy (FNL) can mitigate negative effects of food insecurity on children's eating habits and assist food-insecure households in making better nutrition choices with limited resources available. A cross-sectional study was conducted on children aged 6 to 12 years and their mothers. FNL was assessed using a validated Food and Nutrition Literacy Assessment Tool, and household food security was evaluated with the Household Food Insecurity Access Scale. Eating habits were measured through a structured questionnaire that focused on various dietary habits. Logistic regression was used to determine the associations between maternal FNL, food insecurity status, and children's eating habits. A total of 327 children-mothers, comprising 159 food-secure and 168 food-insecure households, were evaluated. Maternal FNL was inversely associated with consumption of fast-foods and fried foods, and skipping breakfast in both food-secure and food-insecure participants. However, only food-secure participants showed an inverse association between FNL and the habit of eating out. Both groups indicated lower sweet consumption associated with higher FNL. Maternal FNL was inversely associated with lower dairy and nut intake in food-secure group and lower fruit and vegetable consumption in food-insecure participants. This study suggests that in conditions of food insecurity FNL may reduce the negative impact of food insecurity on children's nutrition choices and food habits. CI - Copyright (c) 2024 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Hashemzadeh, Maral AU - Hashemzadeh M AD - Department of Community Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Akhlaghi, Masoumeh AU - Akhlaghi M AD - Department of Community Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Akbarzadeh, Marzieh AU - Akbarzadeh M AD - Department of Community Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Nabizadeh, Kiana AU - Nabizadeh K AD - Department of Community Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Miri, Hamid Heidarian AU - Miri HH AD - School of Food and Nutritional Sciences, University College Cork, Cork, Ireland. FAU - Kazemi, Asma AU - Kazemi A AUID- ORCID: 0000-0001-5032-0078 AD - Nutrition Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - *Feeding Behavior/psychology MH - Male MH - Child MH - *Health Literacy/statistics & numerical data MH - Food Insecurity MH - Adult MH - Mothers/psychology/statistics & numerical data MH - Family Characteristics MH - Food Security/statistics & numerical data MH - Surveys and Questionnaires PMC - PMC11441855 COIS- The authors have no conflicts of interest to disclose. EDAT- 2024/09/27 18:53 MHDA- 2024/09/27 18:54 PMCR- 2024/09/27 CRDT- 2024/09/27 16:23 PHST- 2024/09/27 18:54 [medline] PHST- 2024/09/27 18:53 [pubmed] PHST- 2024/09/27 16:23 [entrez] PHST- 2024/09/27 00:00 [pmc-release] AID - 00005792-202409270-00080 [pii] AID - MD-D-24-08956 [pii] AID - 10.1097/MD.0000000000039812 [doi] PST - ppublish SO - Medicine (Baltimore). 2024 Sep 27;103(39):e39812. doi: 10.1097/MD.0000000000039812. PMID- 39330735 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240929 IS - 2075-4663 (Electronic) IS - 2075-4663 (Linking) VI - 12 IP - 9 DP - 2024 Sep 18 TI - Reliability, Objectivity, Validity, and Reference Levels of the Austrian Pole Climbing Test (APCT)-A Novel Monitoring Tool for Assessing General Fitness in Children, Adolescents, and Young Adults. LID - 10.3390/sports12090258 [doi] LID - 258 AB - Climbing is an activity involving many major muscle groups and, therefore, it is suitable for assessing general physical fitness. The Austrian pole climbing test (APCT) was developed as a reliable and valid test for the assessment of general fitness levels in children, adolescents, and young adults. In this cross-sectional pilot study, 677 participants (aged 6 to 19 years) were assessed via the APCT. Subsequently, test quality criteria (reliability and objectivity) were assessed, and the test's validity was evaluated through comparisons with other established fitness tests (hand grip strength, standing long jump, and pull- and push-ups). Additionally, age- and gender-specific reference values were generated. The reliability (ICC2.1 = 0.97, 95%CI 0.95 to 0.98) and objectivity (ICC2.1 = 0.99, 95%CI 0.99 to 0.99) of the APCT were found to be excellent. The APCT results correlated strongly with the hand strength per kilogram of body weight (right: r = 0.58; left: r = 0.53), number of pull-ups (with upper grip: r = 0.74; with lower grip: r = 0.69) and standing long jump (r = 0.61); a moderate correlation with the push-up test was observed (r = 0.44). The APCT is reliable, objective, and suitable for children, adolescents, and young adults with an affinity for sports. It offers a novel opportunity to assess fitness without time pressure, considering the anthropometric requirements. FAU - Jarnig, Gerald AU - Jarnig G AUID- ORCID: 0000-0003-0885-5866 AD - Institute of Human Movement Science, Sport and Health, University of Graz, 8010 Graz, Austria. FAU - Kerbl, Reinhold AU - Kerbl R AUID- ORCID: 0009-0007-3567-2877 AD - Department of Pediatrics and Adolescent Medicine, LKH Hochsteiermark, 8700 Leoben, Austria. FAU - van Poppel, Mireille N M AU - van Poppel MNM AUID- ORCID: 0000-0001-5694-4324 AD - Institute of Human Movement Science, Sport and Health, University of Graz, 8010 Graz, Austria. LA - eng GR - GZ 2023-0.856.617/Austrian Federal Ministry of Education, Science and Research/ PT - Journal Article DEP - 20240918 PL - Switzerland TA - Sports (Basel) JT - Sports (Basel, Switzerland) JID - 101722684 PMC - PMC11435566 OTO - NOTNLM OT - adolescents OT - children OT - climbing OT - fitness monitoring OT - reference value OT - sport motor test OT - strength endurance OT - talent scouting OT - young adults COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2024/09/27 16:17 MHDA- 2024/09/27 16:18 PMCR- 2024/09/18 CRDT- 2024/09/27 09:44 PHST- 2024/08/26 00:00 [received] PHST- 2024/09/10 00:00 [revised] PHST- 2024/09/13 00:00 [accepted] PHST- 2024/09/27 16:18 [medline] PHST- 2024/09/27 16:17 [pubmed] PHST- 2024/09/27 09:44 [entrez] PHST- 2024/09/18 00:00 [pmc-release] AID - sports12090258 [pii] AID - sports-12-00258 [pii] AID - 10.3390/sports12090258 [doi] PST - epublish SO - Sports (Basel). 2024 Sep 18;12(9):258. doi: 10.3390/sports12090258. PMID- 39329166 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250104 IS - 1932-0248 (Print) IS - 1932-0256 (Electronic) IS - 1932-0256 (Linking) VI - 19 IP - 4 DP - 2024 TI - Associations between Household- and Child-Referenced Food Security Status and Dietary Intake among Low-Income Urban Black Children. PG - 497-512 LID - 10.1080/19320248.2022.2033145 [doi] AB - We examined whether dietary intake differs across household and child food security (FS) status, and Supplemental Nutrition Assistance Program (SNAP) participation among Black children (ages 9-15) in a low-income urban setting. This cross-sectional survey used the USDA 18-item Household Food Security Survey, that includes the 8-item Child Module, and a validated FFQ to assess children's diet (n=451). Nutrient intake differed across child FS status, but not household FS. SNAP participation was associated with better micronutrient intake (vitamin D and calcium) among food secure children. Assessing child-specific FS and nutrient adequacy clarifies children's actual experience and informs child-targeted policies. FAU - Trude, Angela C B AU - Trude ACB AD - Department of Nutrition and Food Studies, New York University, New York , NY, USA. FAU - Vedovato, Gabriela M AU - Vedovato GM AD - Institute of Health and Society, Federal University of Sao Paulo, Santos, SP, Brazil. FAU - Ali, Shahmir H AU - Ali SH AD - School of Global Public Health, New York University, New York, NY, USA. FAU - Black, Maureen M AU - Black MM AD - University of Maryland School of Medicine, Baltimore, 737 W. Lombard St., Baltimore, MD, USA, 21201 & RTI International, Durham, NC, USA. AD - University of Maryland School of Medicine, Baltimore, 737 W. Lombard St., Baltimore, MD, USA, 21201 & RTI International, Durham, NC, USA. FAU - Gittelsohn, Joel AU - Gittelsohn J AD - Center for Human Nutrition, International Health Department, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. LA - eng GR - U54 HD070725/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20220208 PL - United States TA - J Hunger Environ Nutr JT - Journal of hunger & environmental nutrition JID - 101285290 PMC - PMC11424029 MID - NIHMS1776474 OTO - NOTNLM OT - Black OT - Child OT - Diet OT - Food Assistance OT - Food Insecurity OT - Micronutrients COIS- Declaration of interest statement: The authors declare that they have no competing interests. EDAT- 2024/09/27 07:05 MHDA- 2024/09/27 07:06 PMCR- 2025/01/01 CRDT- 2024/09/27 05:39 PHST- 2024/09/27 07:06 [medline] PHST- 2024/09/27 07:05 [pubmed] PHST- 2024/09/27 05:39 [entrez] PHST- 2025/01/01 00:00 [pmc-release] AID - 10.1080/19320248.2022.2033145 [doi] PST - ppublish SO - J Hunger Environ Nutr. 2024;19(4):497-512. doi: 10.1080/19320248.2022.2033145. Epub 2022 Feb 8. PMID- 39327859 OWN - NLM STAT- MEDLINE DCOM- 20250411 LR - 20250411 IS - 2050-439X (Electronic) IS - 2050-4381 (Linking) VI - 12 IP - 16 DP - 2024 Sep TI - Quality of life, capability well-being, financial strain and physical activity in the short- and medium-term COVID-19 post-lockdown phases in the UK: a repeated cross-sectional study. PG - 39-58 LID - 10.3310/LYJG6305 [doi] AB - BACKGROUND: The COVID-19 lockdowns had negative effects on children's and adults' mental and physical health. There is, however, a paucity of research that explores differences in health-related quality of life (HRQL) and well-being over time after the COVID-19 lockdowns had been lifted. Furlough during lockdowns, increases in unemployment, and the emerging cost-of-living crisis all put pressure on family finances, which could have a detrimental effect on HRQL and well-being. This study, part of the wider Active-6 study, explored how HRQL, capability well-being and family financial strain changed after the lockdowns, the relationship between these outcomes, and whether physical activity had any mediating effect on differences in HRQL and capability well-being. METHODS: Cross-sectional data were collected in May-December 2021 (Wave 1) and January-July 2022 (Wave 2). Children (aged 10-11) and their parent/carer were recruited from 23 to 27 schools in each wave, respectively, and completed validated questionnaires measuring HRQL (adults - EQ-5D-5L, children - CHU9D), capability well-being (adults - ICECAP-A) and family financial strain (adults - Family Economic Strain Scale, FESS). Children also completed questions on capability well-being. Weekday minutes of moderate-to-vigorous physical activity (MVPA) were measured using accelerometers. Mixed-effects regression models, adjusted for gender, age group (adults only), IMD and highest household education, were used to explore differences in HRQL and capability well-being between waves. In addition, the moderating effect of financial strain and the mediating effect of MVPA on HRQL and capability well-being were explored. RESULTS: Active-6 recruited 393 parent-child pairs in Wave 1 and 436 in Wave 2. There were no differences in HRQL (EQ-5D, CHU9D) and capability well-being (ICECAP-A) scores between waves, but financial strain was worse in Wave 2 compared to Wave 1 (FESS score difference 1.14 adjusted 95% CI 0.15 to 2.12). Increased financial strain was associated with lower (worse) EQ-5D-5L, CHU9D and ICECAP-A scores. There was no evidence of a mediating effect of MVPA. LIMITATIONS AND FUTURE WORK: Pre-COVID-19 data on HRQL were not collected, so analysis was limited to post-lockdown only. Participating parents were predominantly female and participation was lower among lower socio-economic groups, limiting our ability to explore inequalities. Intervention planning to increase physical activity and health and well-being during the COVID-19 recovery should consider the financial strain families are experiencing and the negative implications of financial strain on HRQL. CONCLUSIONS: There were no differences in HRQL and capability well-being in children and adults after lockdowns lifted in 2021 and a year later in 2022. The results indicate increasing financial strain, which could reflect the UK's 'cost of living crisis'. FUNDING: This article presents independent research funded by the National Institute for Health and Care Research (NIHR) Public Health Research programme as award number NIHR131847. FAU - Breheny, Katie AU - Breheny K AUID- ORCID: 0000-0001-6886-4049 AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. AD - The National Institute for Health Research, Applied Research Collaboration West (NIHR ARC West), University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK. FAU - Salway, Ruth AU - Salway R AUID- ORCID: 0000-0002-3242-3951 AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. AD - Centre for Exercise, Nutrition & Health Sciences, School for Policy Studies, University of Bristol, Bristol, UK. FAU - House, Danielle AU - House D AUID- ORCID: 0000-0001-6171-9922 AD - Centre for Exercise, Nutrition & Health Sciences, School for Policy Studies, University of Bristol, Bristol, UK. FAU - Walker, Robert AU - Walker R AUID- ORCID: 0000-0001-9901-5285 AD - Centre for Exercise, Nutrition & Health Sciences, School for Policy Studies, University of Bristol, Bristol, UK. FAU - Emm-Collison, Lydia AU - Emm-Collison L AUID- ORCID: 0000-0002-5493-3223 AD - Centre for Exercise, Nutrition & Health Sciences, School for Policy Studies, University of Bristol, Bristol, UK. FAU - Sansum, Kate AU - Sansum K AUID- ORCID: 0000-0003-3392-6750 AD - Centre for Exercise, Nutrition & Health Sciences, School for Policy Studies, University of Bristol, Bristol, UK. FAU - Williams, Joanna G AU - Williams JG AUID- ORCID: 0000-0002-4737-1760 AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. AD - Communities and Public Health, Bristol City Council, Bristol, UK. FAU - de Vocht, Frank AU - de Vocht F AUID- ORCID: 0000-0003-3631-627X AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. AD - The National Institute for Health Research, Applied Research Collaboration West (NIHR ARC West), University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK. FAU - Jago, Russell AU - Jago R AUID- ORCID: 0000-0002-3394-0176 AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. AD - The National Institute for Health Research, Applied Research Collaboration West (NIHR ARC West), University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK. AD - Centre for Exercise, Nutrition & Health Sciences, School for Policy Studies, University of Bristol, Bristol, UK. FAU - Hollingworth, William AU - Hollingworth W AUID- ORCID: 0000-0002-0840-6254 AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. AD - The National Institute for Health Research, Applied Research Collaboration West (NIHR ARC West), University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK. LA - eng PT - Journal Article PL - England TA - Public Health Res (Southampt) JT - Public health research (Southampton, England) JID - 101653231 SB - IM MH - Humans MH - Cross-Sectional Studies MH - *COVID-19/epidemiology/psychology MH - *Quality of Life/psychology MH - Male MH - Female MH - *Exercise/psychology MH - United Kingdom/epidemiology MH - Child MH - *Financial Stress/epidemiology/psychology MH - Adult MH - Surveys and Questionnaires MH - SARS-CoV-2 OAB - We know that the COVID-19 pandemic negatively affected people's mental and physical health. But we don't know how quality of life, well-being and pressure on family finances changed for people after the lockdowns were lifted and society reopened. We also wanted to know if these changes were related to how physically active people were. Children and a parent/carer answered questions about their quality of life, well-being and family budget pressures. Physical activity data were also collected using devices worn on their waists. We did this in 2021, when society started to reopen after lockdowns, and a year later in 2022 when all restrictions were gone. We explored differences in quality of life, well-being and pressure on family finances between 2021 and 2022. We then looked at whether any of these differences were because of changes in physical activity, and if financial strain was related to quality of life. We did not find any differences in quality of life or well-being between 2021 and 2022. Financial strain increased slightly. As financial strain increased, quality of life and well-being decreased. This was worse for those experiencing most financial difficulties. Physical activity did not seem to explain differences in quality of life. If family finances are stretched, it might be difficult for families to pay for activities that will help their children be more active. We have also found that family financial difficulties are related to quality of life and well-being. OABL- eng OTO - NOTNLM OT - COVID-19 OT - CROSS-SECTIONAL OT - ECONOMIC SHOCK OT - HEALTH ECONOMICS OT - OUTCOMES RESEARCH OT - PHYSICAL ACTIVITY OT - QUALITY OF LIFE OT - WELL-BEING EDAT- 2024/09/27 07:05 MHDA- 2025/04/11 12:28 CRDT- 2024/09/27 03:12 PHST- 2025/04/11 12:28 [medline] PHST- 2024/09/27 07:05 [pubmed] PHST- 2024/09/27 03:12 [entrez] AID - 10.3310/LYJG6305 [doi] PST - ppublish SO - Public Health Res (Southampt). 2024 Sep;12(16):39-58. doi: 10.3310/LYJG6305. PMID- 39327854 OWN - NLM STAT- MEDLINE DCOM- 20241107 LR - 20251203 IS - 2047-6310 (Electronic) IS - 2047-6302 (Print) IS - 2047-6302 (Linking) VI - 19 IP - 12 DP - 2024 Dec TI - The predictive utility of the in utero exposome for childhood adiposity in independent and integrated frameworks. PG - e13172 LID - 10.1111/ijpo.13172 [doi] AB - OBJECTIVES: To assess the predictive potential of the in utero exposome in relation to childhood adiposity as indicated by body mass index z-scores (BMIz) and the fourth versus first quartile of % fat mass (FM) at median age of 4.6 years. METHODS: We leveraged data on clinical risk factors for childhood obesity during the perinatal period, along with cord blood per/polyfluoroalkyl substances (PFAS) and cord blood DNA methylation, in 268 mother-offspring pairs. We used the sparsity ranked LASSO penalized regression framework for each outcome and assessed model performance based on % variability explained for BMIz and area under the receiver operating characteristic curve (AUC) for the fourth versus first quartile of %FM. We employed cross-validation for model tuning and split-sample validation for model evaluation. RESULTS: Mean +/- SD BMIz was 0.01 +/- 1.1, %FM was 19.8 +/- 6.34%. The optimal model for predicting BMIz explained 19.1% of the variability in the validation set and included only clinical characteristics: maternal pre-pregnancy BMI, paternal BMI, gestational weight gain, physical activity during pregnancy and child race/ethnicity. The optimal model for fourth versus first quartiles of %FM achieved an AUC of 0.82 +/- 0.01 in the validation set, with the clinical features again emerging as the strongest predictors. CONCLUSION: In this study sample, perinatal chemical exposures and the epigenome have low utility in predicting childhood adiposity, beyond known clinical risk factors. CI - (c) 2024 World Obesity Federation. FAU - VanHawkins, Jonathan AU - VanHawkins J AUID- ORCID: 0009-0006-0389-0020 AD - Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FAU - Peterson, Ryan AU - Peterson R AD - Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FAU - Harrall, Kylie AU - Harrall K AD - Department of Epidemiology, Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FAU - Moon, Brandy AU - Moon B AD - Department of Epidemiology, Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FAU - Dabelea, Dana AU - Dabelea D AD - Department of Epidemiology, Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FAU - Kechris, Katerina AU - Kechris K AD - Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FAU - Perng, Wei AU - Perng W AUID- ORCID: 0000-0001-8552-6850 AD - Department of Epidemiology, Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. LA - eng GR - R01 HD112751/HD/NICHD NIH HHS/United States GR - UH3OD023248/NH/NIH HHS/United States GR - UG3 OD023248/OD/NIH HHS/United States GR - UH3 OD023248/OD/NIH HHS/United States GR - U01 DK134981/DK/NIDDK NIH HHS/United States GR - ADA-7-22-ICTSPM-08/American Diabetes Association/ GR - U01 DK134981/NH/NIH HHS/United States PT - Journal Article DEP - 20240926 PL - England TA - Pediatr Obes JT - Pediatric obesity JID - 101572033 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Pediatric Obesity/epidemiology MH - *Adiposity MH - *Prenatal Exposure Delayed Effects/epidemiology MH - Child, Preschool MH - Male MH - *Exposome MH - *Body Mass Index MH - Risk Factors MH - DNA Methylation MH - Adult MH - Fetal Blood/chemistry MH - Child MH - Maternal Exposure/adverse effects/statistics & numerical data PMC - PMC11560695 MID - NIHMS2021322 OTO - NOTNLM OT - DNA methylation OT - childhood adiposity OT - exposome OT - per- and polyfluoroalkyl substances EDAT- 2024/09/27 07:06 MHDA- 2024/11/13 13:58 PMCR- 2025/12/01 CRDT- 2024/09/27 03:03 PHST- 2023/12/14 00:00 [received] PHST- 2024/07/10 00:00 [accepted] PHST- 2024/11/13 13:58 [medline] PHST- 2024/09/27 07:06 [pubmed] PHST- 2024/09/27 03:03 [entrez] PHST- 2025/12/01 00:00 [pmc-release] AID - 10.1111/ijpo.13172 [doi] PST - ppublish SO - Pediatr Obes. 2024 Dec;19(12):e13172. doi: 10.1111/ijpo.13172. Epub 2024 Sep 26. PMID- 39327627 OWN - NLM STAT- MEDLINE DCOM- 20240927 LR - 20261016 IS - 1479-5868 (Electronic) IS - 1479-5868 (Linking) VI - 21 IP - 1 DP - 2024 Sep 26 TI - Validity of the PROMIS((R)) Early Childhood Physical Activity Scale among toddlers. PG - 106 LID - 10.1186/s12966-024-01655-x [doi] LID - 106 AB - BACKGROUND: The PROMIS((R)) Early Childhood Physical Activity (PROMIS EC PA) scale is a recently developed PROMIS Early Childhood measure to assess PA among children aged 1-5 years. The purpose of this study was to examine test-retest reliability and convergent validity of the PROMIS EC PA scale among toddlers. METHOD: An ancillary study was conducted in the toddler-mother dyad sample of the Child and Mother Physical Activity Study. Mothers completed the 7-item PROMIS EC PA scale twice: during a study visit (test) and on the last day when their child's wore an ActiGraph accelerometer on the hip for 7 days (retest). The PROMIS EC PA summed score was calculated by totaling scores from items 1-5. Test-retest reliability was assessed using intraclass correlation coefficient (ICC) for test and retest PROMIS EC PA. Convergent validity was assessed using rank correlation coefficients (rho) between PROMIS EC PA scores and accelerometer-measured moderate- and vigorous-intensity PA (MVPA). RESULTS: Among 74 participants (56% female; 19 +/- 4 months of mean age with range of 12-30 months), average accelerometer-measured MVPA was 76 +/- 24 min/day. The median number of days between PROMIS EC PA test and retest was 8 days (IQR = 6 to 8), with an average PROMIS EC PA summed score of 11.0 +/- 3.5 at test and 10.5 +/- 3.4 at retest. ICC for the test-retest PROMIS EC PA summed scores was 0.72 (95% CI = 0.59-0.82). The rank correlation between the PROMIS EC PA summed score and accelerometer-measured MVPA was 0.13 (95% CI=-0.10 to 0.35; p = 0.28). CONCLUSION: In a sample of children aged 12-30 months, test-retest reliability for the PROMIS EC PA scale was moderate and its convergent validity against accelerometer-measured MVPA was poor. Prior to a widespread use of the PROMIS EC PA scale in large-scale research and clinical practice, the tool should be further refined and validated to elucidate how young children's lived PA experience as measured in the PROMIS EC PA scale is relevant to their health and wellbeing outcomes. CI - (c) 2024. The Author(s). FAU - Kwon, Soyang AU - Kwon S AUID- ORCID: 0000-0002-9359-704X AD - Buehler Center for Health Policy and Economics, Feinberg School of Medicine, Northwestern University, 750 N Lakeshore Drive, Chicago, IL, 60611, USA. soyang.kwon@northwestern.edu. FAU - Armstrong, Bridget AU - Armstrong B AD - Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA. FAU - Wetoska, Nina AU - Wetoska N AD - Buehler Center for Health Policy and Economics, Feinberg School of Medicine, Northwestern University, 750 N Lakeshore Drive, Chicago, IL, 60611, USA. FAU - Capan, Selin AU - Capan S AD - Buehler Center for Health Policy and Economics, Feinberg School of Medicine, Northwestern University, 750 N Lakeshore Drive, Chicago, IL, 60611, USA. LA - eng GR - HL155113/National Institute of Health/ PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Validation Study DEP - 20240926 PL - England TA - Int J Behav Nutr Phys Act JT - The international journal of behavioral nutrition and physical activity JID - 101217089 SB - IM MH - Humans MH - *Exercise MH - Female MH - Reproducibility of Results MH - Child, Preschool MH - Male MH - *Accelerometry/methods MH - Infant MH - *Mothers MH - Surveys and Questionnaires/standards MH - Adult PMC - PMC11425993 OTO - NOTNLM OT - ActiGraph accelerometer OT - Physical activity questionnaire OT - Reliability OT - Young children COIS- The authors declare that they have no competing interests. EDAT- 2024/09/27 00:42 MHDA- 2024/09/27 07:06 PMCR- 2024/09/26 CRDT- 2024/09/26 23:46 PHST- 2024/06/06 00:00 [received] PHST- 2024/09/11 00:00 [accepted] PHST- 2024/09/27 07:06 [medline] PHST- 2024/09/27 00:42 [pubmed] PHST- 2024/09/26 23:46 [entrez] PHST- 2024/09/26 00:00 [pmc-release] AID - 10.1186/s12966-024-01655-x [pii] AID - 1655 [pii] AID - 10.1186/s12966-024-01655-x [doi] PST - epublish SO - Int J Behav Nutr Phys Act. 2024 Sep 26;21(1):106. doi: 10.1186/s12966-024-01655-x. PMID- 39327067 OWN - NLM STAT- MEDLINE DCOM- 20240926 LR - 20260728 IS - 2052-4897 (Electronic) IS - 2052-4897 (Linking) VI - 12 IP - 5 DP - 2024 Sep 26 TI - Applying machine learning approaches for predicting obesity risk using US health administrative claims database. LID - 10.1136/bmjdrc-2024-004193 [doi] LID - e004193 AB - INTRODUCTION: Body mass index (BMI) is inadequately recorded in US administrative claims databases. We aimed to validate the sensitivity and positive predictive value (PPV) of BMI-related diagnosis codes using an electronic medical records (EMR) claims-linked database. Additionally, we applied machine learning (ML) to identify features in US claims databases to predict obesity status. RESEARCH DESIGN AND METHODS: This observational, retrospective analysis included 692 119 people >/=18 years of age, with >/=1 BMI reading in MarketScan Explorys Claims-EMR data (January 2013-December 2019). Claims-based obesity status was compared with EMR-based BMI (gold standard) to assess BMI-related diagnosis code sensitivity and PPV. Logistic regression (LR), penalized LR with L1 penalty (Least Absolute Shrinkage and Selection Operator), extreme gradient boosting (XGBoost) and random forest, with features drawn from insurance claims, were trained to predict obesity status (BMI>/=30 kg/m(2)) from EMR as the gold standard. Model performance was compared using several metrics, including the area under the receiver operating characteristic curve. The best-performing model was applied to assess feature importance. Obesity risk scores were computed from the best model generated from the claims database and compared against the BMI recorded in the EMR. RESULTS: The PPV of diagnosis codes from claims alone remained high over the study period (85.4-89.2%); sensitivity was low (16.8-44.8%). XGBoost performed the best at predicting obesity with the highest area under the curve (AUC; 79.4%) and the lowest Brier score. The number of obesity diagnoses and obesity diagnoses from inpatient settings were the most important predictors of obesity. XGBoost showed an AUC of 74.1% when trained without an obesity diagnosis. CONCLUSIONS: Obesity prevalence is under-reported in claims databases. ML models, with or without explicit obesity, show promise in improving obesity prediction accuracy compared with obesity codes alone. Improved obesity status prediction may assist practitioners and payors to estimate the burden of obesity and investigate the potential unmet needs of current treatments. CI - (c) Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Choong, Casey AU - Choong C AUID- ORCID: 0000-0001-6476-784X AD - Eli Lilly and Company, Indianapolis, Indiana, USA choong_kar-chan@lilly.com. FAU - Brnabic, Alan AU - Brnabic A AD - Eli Lilly and Company, Indianapolis, Indiana, USA. FAU - Chinthammit, Chanadda AU - Chinthammit C AD - Eli Lilly and Company, Indianapolis, Indiana, USA. FAU - Ravuri, Meena AU - Ravuri M AD - Eli Lilly and Company, Indianapolis, Indiana, USA. FAU - Terrell, Kendra AU - Terrell K AD - Eli Lilly and Company, Indianapolis, Indiana, USA. FAU - Kan, Hong AU - Kan H AD - Eli Lilly and Company, Indianapolis, Indiana, USA. LA - eng PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20240926 PL - England TA - BMJ Open Diabetes Res Care JT - BMJ open diabetes research & care JID - 101641391 SB - IM MH - Humans MH - *Machine Learning MH - *Obesity/epidemiology MH - Male MH - Female MH - Retrospective Studies MH - Middle Aged MH - *Body Mass Index MH - Adult MH - *Databases, Factual MH - United States/epidemiology MH - *Electronic Health Records/statistics & numerical data MH - Aged MH - Risk Factors MH - Young Adult MH - Prognosis MH - Administrative Claims, Healthcare/statistics & numerical data MH - Risk Assessment MH - Adolescent MH - ROC Curve PMC - PMC11429277 OTO - NOTNLM OT - Body Mass Index OT - Database OT - Obesity COIS- Competing interests: CCho, AB, CChi, KT and HK are employees and stockholders of Eli Lilly and Company, Indiana, USA. MR was an employee of Eli Lilly and Company at the time of the study. EDAT- 2024/09/27 00:42 MHDA- 2024/09/27 00:43 PMCR- 2024/09/26 CRDT- 2024/09/26 21:33 PHST- 2024/03/14 00:00 [received] PHST- 2024/09/12 00:00 [accepted] PHST- 2024/09/27 00:43 [medline] PHST- 2024/09/27 00:42 [pubmed] PHST- 2024/09/26 21:33 [entrez] PHST- 2024/09/26 00:00 [pmc-release] AID - 12/5/e004193 [pii] AID - bmjdrc-2024-004193 [pii] AID - 10.1136/bmjdrc-2024-004193 [doi] PST - epublish SO - BMJ Open Diabetes Res Care. 2024 Sep 26;12(5):e004193. doi: 10.1136/bmjdrc-2024-004193. PMID- 39326431 OWN - NLM STAT- MEDLINE DCOM- 20241109 LR - 20260518 IS - 2468-1253 (Electronic) VI - 9 IP - 12 DP - 2024 Dec TI - Spleen stiffness measurement by vibration-controlled transient elastography at 100 Hz for non-invasive predicted diagnosis of clinically significant portal hypertension in patients with compensated advanced chronic liver disease: a modelling study. PG - 1111-1120 LID - S2468-1253(24)00234-6 [pii] LID - 10.1016/S2468-1253(24)00234-6 [doi] AB - BACKGROUND: In patients with compensated advanced chronic liver disease (cACLD), risk of clinically significant portal hypertension (CSPH) can be estimated by applying non-invasive tests such as liver stiffness measurement (LSM), platelet count, and, in some cases, BMI. We aimed to assess the diagnostic utility of spleen stiffness measurement (SSM) at 100 Hz as a standalone non-invasive test for CSPH and to evaluate its incremental value compared with the ANTICIPATE+/-NASH model in patients with cACLD. METHODS: For this modelling study, patients were recruited from 16 expert centres in Europe. Patients who underwent characterisation by hepatic venous pressure gradient (HVPG) and non-invasive tests (ie, LSM, platelet count, and SSM at 100 Hz) at one of the participating centres between Jan 1, 2020, and Dec 31, 2023, were considered for inclusion. Only patients aged 18 years or older with Child-Pugh class A cACLD, shown by LSM 10 kPa or more or F3 or F4 fibrosis on liver histology, were included. The overall cohort was split into the derivation cohort (patients recruited between Jan 1, 2020, and Dec 31, 2022) and the temporal validation cohort (patients recruited between Jan 1, 2023, and Dec 31, 2023). The ANTICIPATE+/-NASH model was applied to assess individual CSPH probability and SSM was investigated as a standalone non-invasive test for CPSH; in combination with platelet count and BMI; and in a full model of SSM, LSM, platelet count, and BMI (ie, the Non-Invasive CSPH Estimated Risk [NICER] model). All models were binary logistic regression models. The primary outcome was CSPH. We evaluated the discriminative utility of the models by calculating the area under the receiver operating characteristics curve (AUC) and creating calibration plots and calibration of intercept, slope, and integrated calibration index. FINDINGS: 407 patients with cACLD were included, 202 (50%) in the derivation cohort and 205 (50%) in the validation cohort. Median age was 60.0 years (IQR 55.0-66.8); 275 (68%) of 407 patients were male and 132 (32%) were female. 164 (40%) of 407 patients had metabolic dysfunction-associated steatotic liver disease (MASLD), 133 (33%) had MASLD with increased alcohol intake or alcohol-related liver disease, 75 (18%) had viral hepatitis (61 [81%] of whom had sustained virologic response of hepatitis C virus or suppression of hepatitis B virus DNA), and 35 (9%) had other chronic liver diseases. 241 (59%) patients had CSPH. Median SSM was 45.0 kPa (32.1-65.4) and LSM was 21.4 kPa (14.1-31.6). SSM and LSM had similar AUCs for prediction of CSPH in the derivation cohort (0.779 [95% CI 0.717-0.842] vs 0.781 [0.718-0.844]; p=0.97) and in the validation cohort (0.830 [0.772-0.887] vs 0.804 [0.743-0.864]; p=0.50). The SSM-based model comprising platelet count and BMI had a similar AUC as the ANTICIPATE+/-NASH model in both the derivation cohort (0.849 [0.794-0.903] vs 0.849 [0.794-0.903]; p=0.999) and in the validation cohort (0.873 [0.819-0.922] vs 0.863 [0.810-0.916]; p=0.75). The NICER model had a significantly higher AUC for prediction of CSPH than the ANTICIPATE+/-NASH model in the derivation cohort (0.889 [0.843-0.934] vs 0.849 [0.794-0.903]; p=0.022) and in the validation cohort (0.906 [0.864-0.946] vs 0.863 [0.810-0.916]; p=0.012). INTERPRETATION: The addition of SSM to LSM, BMI, and platelet count outperformed the ANTICIPATE+/-NASH model for CSPH risk stratification in our cohort of contemporary patients with cACLD. SSM improves the non-invasive diagnosis of CSPH, supporting its implementation into clinical practice. FUNDING: Echosens. CI - Copyright (c) 2024 Elsevier Ltd. All rights reserved, including those for text and data mining, AI training, and similar technologies. FAU - Jachs, Mathias AU - Jachs M AD - Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria; Vienna Hepatic Hemodynamic Lab, Medical University of Vienna, Vienna, Austria; Department of Medicine III and Clinical Research Group Mechanisms in Portal Hypertension, Medical University of Vienna, Vienna, Austria. FAU - Odriozola, Aitor AU - Odriozola A AD - Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute, Marques de Valdecilla University Hospital, Santander, Spain. FAU - Turon, Fanny AU - Turon F AD - Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, Institut de Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Centro de Investigacion Biomedica en Red Enfermedades Hepaticas y Digestivas, University of Alcala, Madrid, Spain; European Reference Network on Rare Liver Disorders, Hamburg, Germany. FAU - Moga, Lucile AU - Moga L AD - Institut National de la Sante et de la Recherche Medicale, Centre de Recherche sur l'Inflammation, Universite Paris-Cite, Unite Mixte de Recherche 1149, Paris, France; Service d'Hepatologie, Assistance Publique-Hopitaux de Paris, Hopital Beaujon, Departements Medico-Universitaires Maladies de l'Appareil Digestif, Centre de Reference des Maladies Vasculaires du Foie, French Network for Rare Liver Diseases and European Reference Network on Rare Liver Disorders, Paris, France. FAU - Tellez, Luis AU - Tellez L AD - Instituto Ramon y Cajal de Investigacion Sanitaria, University of Alcala, Madrid, Spain; Gastroenterology and Hepatology Department, Hospital Universitario Ramon y Cajal, Madrid, Spain. FAU - Fischer, Petra AU - Fischer P AD - Third Medical Clinic, Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. FAU - Saltini, Dario AU - Saltini D AD - Gastroenterology Unit, Department of Medical Specialties, University of Modena, Reggio Emilia, and Azienda Ospedaliero-Universitaria di Modena, Modena, Italy; Severe Liver Diseases Unit, Department of Medical Specialties, University of Modena, Reggio Emilia, and Azienda Ospedaliero-Universitaria di Modena, Modena, Italy. FAU - Kwanten, Wilhelmus J AU - Kwanten WJ AD - European Reference Network on Rare Liver Disorders, Hamburg, Germany; Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium; Laboratory of Experimental Medicine and Pediatrics-Gastroenterology and Hepatology, University of Antwerp, Antwerp, Belgium. FAU - Grasso, Maria AU - Grasso M AD - Gastroenterology and Hepatology Unit, Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialities, Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza G D'Alessandro, University of Palermo, Palermo, Italy. FAU - Llop, Elba AU - Llop E AD - Department of Gastroenterology and Hepatology, Puerta de Hierro University Hospital, Puerta de Hierro Health Research Institute, Centro de Investigacion Biomedica en Red Enfermedades Hepaticas y Digestivas, Universidad Autonoma de Madrid, Madrid, Spain. FAU - Mendoza, Yuly P AU - Mendoza YP AD - Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland. FAU - Armandi, Angelo AU - Armandi A AD - Metabolic Liver Disease Research Program, Department of Medicine, University Medical Center Mainz, Mainz, Germany; Division of Gastroenterology and Hepatology, Department of Medical Sciences, University of Turin, Turin, Italy. FAU - Thalhammer, Julia AU - Thalhammer J AD - Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria; Vienna Hepatic Hemodynamic Lab, Medical University of Vienna, Vienna, Austria. FAU - Pardo, Carlos AU - Pardo C AD - Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, Institut de Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Centro de Investigacion Biomedica en Red Enfermedades Hepaticas y Digestivas, University of Alcala, Madrid, Spain; European Reference Network on Rare Liver Disorders, Hamburg, Germany. FAU - Colecchia, Antonio AU - Colecchia A AD - Gastroenterology Unit, Department of Medical Specialties, University of Modena, Reggio Emilia, and Azienda Ospedaliero-Universitaria di Modena, Modena, Italy. FAU - Ravaioli, Federico AU - Ravaioli F AD - Istituto di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliero and Department of Medical and Surgical Sciences, Universitaria di Bologna, European Reference Network on Hepatological Diseases, Bologna, Italy. FAU - Maasoumy, Benjamin AU - Maasoumy B AD - Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany. FAU - Laleman, Wim AU - Laleman W AD - Department of Gastroenterology and Hepatology, Section of Liver and Biliopancreatic Disorders and Liver Transplantation, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium; Medizinische Klinik B, Universitatsklinikum Munster, Munster University, Munster, Germany. FAU - Presa, Jose AU - Presa J AD - Liver Unit, Hospital Center of Tras-os-Montes and Alto Douro, Vila Real, Portugal. FAU - Schattenberg, Jorn M AU - Schattenberg JM AD - Metabolic Liver Disease Research Program, Department of Medicine, University Medical Center Mainz, Mainz, Germany; Department of Internal Medicine II, Saarland University Medical Center, Homburg, Germany. FAU - Berzigotti, Annalisa AU - Berzigotti A AD - Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland. FAU - Calleja, Jose L AU - Calleja JL AD - Department of Gastroenterology and Hepatology, Puerta de Hierro University Hospital, Puerta de Hierro Health Research Institute, Centro de Investigacion Biomedica en Red Enfermedades Hepaticas y Digestivas, Universidad Autonoma de Madrid, Madrid, Spain. FAU - Calvaruso, Vincenza AU - Calvaruso V AD - Gastroenterology and Hepatology Unit, Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialities, Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza G D'Alessandro, University of Palermo, Palermo, Italy. FAU - Francque, Sven AU - Francque S AD - Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium; Laboratory of Experimental Medicine and Pediatrics-Gastroenterology and Hepatology, University of Antwerp, Antwerp, Belgium. FAU - Schepis, Filippo AU - Schepis F AD - Gastroenterology Unit, Department of Medical Specialties, University of Modena, Reggio Emilia, and Azienda Ospedaliero-Universitaria di Modena, Modena, Italy; Severe Liver Diseases Unit, Department of Medical Specialties, University of Modena, Reggio Emilia, and Azienda Ospedaliero-Universitaria di Modena, Modena, Italy. FAU - Procopet, Bogdan AU - Procopet B AD - Third Medical Clinic, Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. FAU - Albillos, Agustin AU - Albillos A AD - Instituto Ramon y Cajal de Investigacion Sanitaria, University of Alcala, Madrid, Spain; Gastroenterology and Hepatology Department, Hospital Universitario Ramon y Cajal, Madrid, Spain. FAU - Rautou, Pierre-Emmanuel AU - Rautou PE AD - Institut National de la Sante et de la Recherche Medicale, Centre de Recherche sur l'Inflammation, Universite Paris-Cite, Unite Mixte de Recherche 1149, Paris, France; Service d'Hepatologie, Assistance Publique-Hopitaux de Paris, Hopital Beaujon, Departements Medico-Universitaires Maladies de l'Appareil Digestif, Centre de Reference des Maladies Vasculaires du Foie, French Network for Rare Liver Diseases and European Reference Network on Rare Liver Disorders, Paris, France. FAU - Garcia-Pagan, Juan C AU - Garcia-Pagan JC AD - Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, Institut de Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; Centro de Investigacion Biomedica en Red Enfermedades Hepaticas y Digestivas, University of Alcala, Madrid, Spain; European Reference Network on Rare Liver Disorders, Hamburg, Germany. FAU - Puente, Angela AU - Puente A AD - Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute, Marques de Valdecilla University Hospital, Santander, Spain. FAU - Fortea, Jose I AU - Fortea JI AD - Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute, Marques de Valdecilla University Hospital, Santander, Spain. FAU - Reiberger, Thomas AU - Reiberger T AD - Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria; Department of Medicine III and Clinical Research Group Mechanisms in Portal Hypertension, Medical University of Vienna, Vienna, Austria. FAU - Mandorfer, Mattias AU - Mandorfer M AD - Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria; Vienna Hepatic Hemodynamic Lab, Medical University of Vienna, Vienna, Austria; Department of Medicine III and Clinical Research Group Mechanisms in Portal Hypertension, Medical University of Vienna, Vienna, Austria. Electronic address: mattias.mandorfer@meduniwien.ac.at. CN - SSM-100Hz/ACLD Study Group CN - Baveno Cooperation LA - eng PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20240923 PL - Netherlands TA - Lancet Gastroenterol Hepatol JT - The lancet. Gastroenterology & hepatology JID - 101690683 SB - IM CIN - Lancet Gastroenterol Hepatol. 2024 Dec;9(12):1067-1069. doi: 10.1016/S2468-1253(24)00249-8. PMID: 39326430 CIN - Hepatobiliary Surg Nutr. 2025 Aug 1;14(4):658-661. doi: 10.21037/hbsn-2025-294. PMID: 40893752 MH - Humans MH - *Elasticity Imaging Techniques/methods MH - *Hypertension, Portal/diagnosis/etiology MH - Female MH - Male MH - Middle Aged MH - *Spleen/diagnostic imaging/pathology MH - Aged MH - Platelet Count MH - Vibration MH - Predictive Value of Tests MH - ROC Curve MH - Liver Diseases/complications/diagnosis/diagnostic imaging MH - Liver Cirrhosis/complications MH - Chronic Disease COIS- Declaration of interests MJ has been a speaker and consultant for Gilead. FT has been a speaker for W L Gore & Associates. LT has been a speaker, consultant, or advisory board member for AbbVie, Eisai, Gilead, Janssen, and W L Gore & Associates and has received travel support from AbbVie, Janssen, Roche, and Gilead. WJK has been a speaker for the panNASH initiative; has received travel grants from Ipsen and Norgine; and is a co-inventor and patent holder for the use of lipopigment imaging for disease (filed by Massachusetts General Hospital and Massachusetts Institute of Technology; US 20190307390). AC has been a speaker and consultant for Jazz Pharmaceuticals. BM received grants and research support from Abbott, Fujirebio, Ewimed, and Roche and personal fees from Abbott, AbbVie, BMS, Janssen, Luvos, Merck, MSD, Roche, Fujirebio, Norgine, Gilead, and Astellas. WL has been a consultant for Cook Medical, Boston Scientific, CSL Behring, and MRM Health. JP has been a speaker, consultant, or advisory board member for AbbVie, Gilead, Advanz, MSD, Roche, AstraZeneca, Eisai, Orphalan, and Sobi. JMS has been a consultant and advisory board member for AbbVie; has received honoraria from Apollo Endoscopy, Boehringer Ingelheim, Gilead, Advanz Sciences, Intercept Pharmaceuticals, Ipsen, Inventiva Pharma, Madrigal Pharmaceuticals, MSD, Northsea Therapeutics, Novartis, Novo Nordisk, Pfizer, Roche, AstraZeneca, Eisai, OrphalanSanofi, and Siemens Healthineers; has received research funding from Boehringer Ingelheim and Siemens Healthcare; has received speaker honoraria from Boehringer Ingelheim, Echosens, MedPublico, Novo Nordisk, Madrigal Pharmaceuticals, and Histoindex; and holds stockholder options in AGED diagnostics and Sobi JHepta Bio. AB has been a speaker or consultant for Boehringer Ingelheim, GE HealthCare, Hologic, and W L Gore & Associates. VC has been a speaker, consultant, or advisory board member for Advanz, Ipsen, AbbVie, Echosens, Gilead, and Roche and has received grants and research support from Advanz and MSD. SF has been a speaker or consultant for W L Gore & Associates, Cook Medical, and Echosens and has received grants and research support from W L Gore & Associates and Cook Medical. FS has been a speaker or consultant for W L Gore & Associates, Cook Medical, and Echosens and has received grants and research support from W L Gore & Associates and Cook Medical. BP has been a speaker for AbbVie and Echosens. AAl has received fellowship funding from United European Gastroenterology. P-ER has received research funding from Terrafirma and has been a speaker or consultant for Abbelight, AbbVie, Hemostod, Mursla, Genfit, Boehringer Ingelheim, and Tillots Pharma. JCG is an advisory board member for W L Gore & Associates and Cook and has received grant support from Mallinckrodt, CSL Vifor, and AstraZeneca. JIF has been a speaker for Grifols and has received travel support from Gilead. TR has been a speaker, consultant, or advisory board member for AbbVie, Bayer, Boehringer Ingelheim, Gilead, Intercept, MSD, Siemens, and W L Gore & Associates; has received grants and research support from AbbVie, Boehringer Ingelheim, Gilead, Intercept, MSD, Myr Pharmaceuticals, Pliant, Philips, Siemens, and W L Gore & Associates; and has received travel support from AbbVie, Boehringer Ingelheim, Gilead, and Roche. MM received a research grant from Echosens for the coordination of this study; has been a speaker, consultant, or advisory board member for AbbVie, Echosens, Gilead, Ipsen, and W L Gore & Associates and has received travel support from AbbVie and Gilead. All other authors declare no competing interests. FIR - Kuner, Charlotte IR - Kuner C FIR - Stattermayer, Albert Friedrich IR - Stattermayer AF FIR - Trauner, Michael IR - Trauner M FIR - Hernandez-Gea, Virginia IR - Hernandez-Gea V FIR - Payance, Audrey IR - Payance A FIR - Roux, Olivier IR - Roux O FIR - Issoufaly, Tazime IR - Issoufaly T FIR - Valainathan, Shantha IR - Valainathan S FIR - de Broucker, Chloe IR - de Broucker C FIR - Torres, Maria IR - Torres M FIR - Stefanescu, Horia IR - Stefanescu H FIR - Platon, Monica IR - Platon M FIR - Fodor, Andreea IR - Fodor A FIR - Nicoara-Farcau, Oana IR - Nicoara-Farcau O FIR - Bianchini, Marcello IR - Bianchini M FIR - Guasconi, Tomas IR - Guasconi T FIR - Vanwolleghem, Thomas IR - Vanwolleghem T FIR - Schoenmakers, Lotte IR - Schoenmakers L FIR - Vonghia, Luisa IR - Vonghia L FIR - Labenz, Christian IR - Labenz C FIR - Dajti, Elton IR - Dajti E FIR - Colecchia, Luigi IR - Colecchia L FIR - Vanderschueren, Emma IR - Vanderschueren E FIR - Sandmann, Lisa IR - Sandmann L FIR - Greenfield, Helena IR - Greenfield H EDAT- 2024/09/27 00:42 MHDA- 2024/11/13 13:47 CRDT- 2024/09/26 18:52 PHST- 2024/04/24 00:00 [received] PHST- 2024/07/17 00:00 [revised] PHST- 2024/07/17 00:00 [accepted] PHST- 2024/11/13 13:47 [medline] PHST- 2024/09/27 00:42 [pubmed] PHST- 2024/09/26 18:52 [entrez] AID - S2468-1253(24)00234-6 [pii] AID - 10.1016/S2468-1253(24)00234-6 [doi] PST - ppublish SO - Lancet Gastroenterol Hepatol. 2024 Dec;9(12):1111-1120. doi: 10.1016/S2468-1253(24)00234-6. Epub 2024 Sep 23. PMID- 39326044 OWN - NLM STAT- MEDLINE DCOM- 20240926 LR - 20250825 IS - 1438-8871 (Electronic) IS - 1439-4456 (Print) IS - 1438-8871 (Linking) VI - 26 DP - 2024 Sep 26 TI - A Mobile Gaming App to Train Teenage Mothers on Appropriate Child Feeding Practices: Development and Validation Study. PG - e53560 LID - 10.2196/53560 [doi] LID - e53560 AB - BACKGROUND: Undernutrition is an underlying factor in nearly 50% of 1 million estimated annual deaths among Nigerian children aged <5 years. Inappropriate maternal infant and young child feeding (IYCF) practices are basic contributors to child undernutrition. Teenage motherhood exacerbates the problem of inadequate child feeding. One possible intervention method to improve IYCF knowledge and practices of teenage mothers is the use of mobile gaming technologies. Despite extreme poverty in low- and middle-income countries, a ubiquity of mobile phone networks exists. OBJECTIVE: This study aims to develop and validate a mobile gaming app, called BabyThrive, to train Nigerian teenage mothers on appropriate IYCF practices. METHODS: To identify gaps in current IYCF practices in northern Nigeria, we conducted an extensive search of the literature and held 2 focus group interviews with 16 teenage mothers with low-income status. An initial app content design was then created, and content validity was established by 10 nutrition experts. Next, we developed an app prototype, which was assessed for quality by 7 nutrition and mobile gaming experts and evaluated for usability by 90 teenage mothers from rural areas in Abuja, the country's capital. The final app, BabyThrive, is a 2D mobile game that is fully functional offline and available in English as well as Hausa, which is commonly spoken in northern Nigeria. The efficacy of the BabyThrive app was assessed using IYCF knowledge scores obtained from the administration of the validated Teen Moms Child Feeding Questionnaire for Sub-Saharan Africa. Construct validity was established via crossover design by comparing the total IYCF knowledge scores of the teenage mothers obtained after a verbal training program and BabyThrive app use. RESULTS: Large proportions of the study participants were married (53/90, 59%) and had no personal income (63/90, 70%). The mean quality rating for the BabyThrive app was 4.3 (SD 0.39) out of 5.0. High levels (>80%) of usability and user satisfaction were documented. Knowledge of exclusive breastfeeding (P<.001) and total knowledge scores (P=.002) were significantly higher in the BabyThrive group than in the verbal training group. The IYCF knowledge scores obtained from both groups showed coherence, with a statistically significant Spearman correlation coefficient of 0.50 (P<.001). CONCLUSIONS: This research developed and validated a novel, offline mobile gaming app. It will be an easy, effective, and acceptable method to disseminate critical knowledge on IYCF practices to teenage mothers in rural Nigeria. CI - (c)Mercy Eloho Sosanya, Folake Olukemi Samuel, Sadia Bashir, Victoria Osariemen Omoera, Jeanne H Freeland-Graves. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 26.09.2024. FAU - Sosanya, Mercy Eloho AU - Sosanya ME AUID- ORCID: 0000-0001-9802-0269 AD - Department of Nutritional Sciences, University of Texas at Austin, Austin, TX, United States. AD - Department of Nutrition and Dietetics, The Federal Polytechnic, Bauchi, Bauchi, Nigeria. FAU - Samuel, Folake Olukemi AU - Samuel FO AUID- ORCID: 0000-0001-5019-4526 AD - Department of Human Nutrition and Dietetics, College of Medicine, University of Ibadan, Ibadan, Nigeria. FAU - Bashir, Sadia AU - Bashir S AUID- ORCID: 0009-0006-7259-7047 AD - PixelArt Games Academy, Islamabad, Pakistan. FAU - Omoera, Victoria Osariemen AU - Omoera VO AUID- ORCID: 0009-0009-9504-4973 AD - Centre for Family Health Initiative, Abuja, Nigeria. FAU - Freeland-Graves, Jeanne H AU - Freeland-Graves JH AUID- ORCID: 0000-0002-0456-8993 AD - Department of Nutritional Sciences, University of Texas at Austin, Austin, TX, United States. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20240926 PL - Canada TA - J Med Internet Res JT - Journal of medical Internet research JID - 100959882 SB - IM MH - Humans MH - Adolescent MH - *Mobile Applications MH - Female MH - *Mothers/education MH - Nigeria MH - Infant MH - Focus Groups MH - Pregnancy in Adolescence MH - Child, Preschool PMC - PMC11467632 OTO - NOTNLM OT - Nigeria OT - infant and young child feeding OT - mHealth OT - mobile gaming app OT - mobile health OT - mobile phone OT - teenage mother OT - validation COIS- Conflicts of Interest: None declared. EDAT- 2024/09/26 19:03 MHDA- 2024/09/26 19:04 PMCR- 2024/09/26 CRDT- 2024/09/26 16:53 PHST- 2023/10/10 00:00 [received] PHST- 2024/06/07 00:00 [accepted] PHST- 2024/04/20 00:00 [revised] PHST- 2024/09/26 19:04 [medline] PHST- 2024/09/26 19:03 [pubmed] PHST- 2024/09/26 16:53 [entrez] PHST- 2024/09/26 00:00 [pmc-release] AID - v26i1e53560 [pii] AID - 10.2196/53560 [doi] PST - epublish SO - J Med Internet Res. 2024 Sep 26;26:e53560. doi: 10.2196/53560. PMID- 39326040 OWN - NLM STAT- MEDLINE DCOM- 20240926 LR - 20260701 IS - 2369-2960 (Electronic) IS - 2369-2960 (Linking) VI - 10 DP - 2024 Sep 26 TI - Identifying Potential Factors Associated With Racial Disparities in COVID-19 Outcomes: Retrospective Cohort Study Using Machine Learning on Real-World Data. PG - e54421 LID - 10.2196/54421 [doi] LID - e54421 AB - BACKGROUND: Racial disparities in COVID-19 incidence and outcomes have been widely reported. Non-Hispanic Black patients endured worse outcomes disproportionately compared with non-Hispanic White patients, but the epidemiological basis for these observations was complex and multifaceted. OBJECTIVE: This study aimed to elucidate the potential reasons behind the worse outcomes of COVID-19 experienced by non-Hispanic Black patients compared with non-Hispanic White patients and how these variables interact using an explainable machine learning approach. METHODS: In this retrospective cohort study, we examined 28,943 laboratory-confirmed COVID-19 cases from the OneFlorida Research Consortium's data trust of health care recipients in Florida through April 28, 2021. We assessed the prevalence of pre-existing comorbid conditions, geo-socioeconomic factors, and health outcomes in the structured electronic health records of COVID-19 cases. The primary outcome was a composite of hospitalization, intensive care unit admission, and mortality at index admission. We developed and validated a machine learning model using Extreme Gradient Boosting to evaluate predictors of worse outcomes of COVID-19 and rank them by importance. RESULTS: Compared to non-Hispanic White patients, non-Hispanic Blacks patients were younger, more likely to be uninsured, had a higher prevalence of emergency department and inpatient visits, and were in regions with higher area deprivation index rankings and pollutant concentrations. Non-Hispanic Black patients had the highest burden of comorbidities and rates of the primary outcome. Age was a key predictor in all models, ranking highest in non-Hispanic White patients. However, for non-Hispanic Black patients, congestive heart failure was a primary predictor. Other variables, such as food environment measures and air pollution indicators, also ranked high. By consolidating comorbidities into the Elixhauser Comorbidity Index, this became the top predictor, providing a comprehensive risk measure. CONCLUSIONS: The study reveals that individual and geo-socioeconomic factors significantly influence the outcomes of COVID-19. It also highlights varying risk profiles among different racial groups. While these findings suggest potential disparities, further causal inference and statistical testing are needed to fully substantiate these observations. Recognizing these relationships is vital for creating effective, tailored interventions that reduce disparities and enhance health outcomes across all racial and socioeconomic groups. CI - (c)Osama Dasa, Chen Bai, Ruba Sajdeya, Stephen E Kimmel, Carl J Pepine, Matthew J Gurka J, Reinhard Laubenbacher, Thomas A Pearson, Mamoun T Mardini. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org), 26.09.2024. FAU - Dasa, Osama AU - Dasa O AUID- ORCID: 0000-0003-2645-8530 AD - Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, United States. AD - Division of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville, FL, United States. FAU - Bai, Chen AU - Bai C AUID- ORCID: 0000-0003-0961-1927 AD - Department of Health Outcomes and Biomedical Informatics, University of Florida, Gainesville, FL, United States. FAU - Sajdeya, Ruba AU - Sajdeya R AUID- ORCID: 0000-0002-1101-3603 AD - Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, United States. FAU - Kimmel, Stephen E AU - Kimmel SE AUID- ORCID: 0000-0003-3673-2361 AD - Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, United States. FAU - Pepine, Carl J AU - Pepine CJ AUID- ORCID: 0000-0002-6011-681X AD - Division of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville, FL, United States. FAU - Gurka J, Matthew J AU - Gurka J MJ AUID- ORCID: 0000-0002-3371-4582 AD - Department of Public Health Sciences, School of Medicine, University of Virginia, Charlottesville, VA, United States. FAU - Laubenbacher, Reinhard AU - Laubenbacher R AUID- ORCID: 0000-0002-9143-9451 AD - Laboratory for Systems Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL, United States. FAU - Pearson, Thomas A AU - Pearson TA AUID- ORCID: 0000-0001-8370-0595 AD - Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, United States. FAU - Mardini, Mamoun T AU - Mardini MT AUID- ORCID: 0000-0002-5345-8811 AD - Department of Health Outcomes and Biomedical Informatics, University of Florida, Gainesville, FL, United States. LA - eng PT - Journal Article DEP - 20240926 PL - Canada TA - JMIR Public Health Surveill JT - JMIR public health and surveillance JID - 101669345 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - *Black or African American MH - Cohort Studies MH - *COVID-19/ethnology/epidemiology MH - Florida/epidemiology MH - *Health Status Disparities MH - *Machine Learning MH - Retrospective Studies MH - Risk Factors MH - Socioeconomic Factors MH - White PMC - PMC11467607 OTO - NOTNLM OT - COVID-19 OT - COVID-19 outcomes OT - SARS-CoV-2 OT - area deprivation index OT - health disparities OT - health outcomes OT - machine learning OT - racial disparities OT - real-world data OT - social determinants of health OT - socioeconomic status COIS- Conflicts of Interest: None declared. EDAT- 2024/09/26 19:03 MHDA- 2024/09/26 19:04 PMCR- 2024/09/26 CRDT- 2024/09/26 16:53 PHST- 2023/11/12 00:00 [received] PHST- 2024/05/29 00:00 [accepted] PHST- 2024/04/01 00:00 [revised] PHST- 2024/09/26 19:04 [medline] PHST- 2024/09/26 19:03 [pubmed] PHST- 2024/09/26 16:53 [entrez] PHST- 2024/09/26 00:00 [pmc-release] AID - v10i1e54421 [pii] AID - 10.2196/54421 [doi] PST - epublish SO - JMIR Public Health Surveill. 2024 Sep 26;10:e54421. doi: 10.2196/54421. PMID- 39320590 OWN - NLM STAT- MEDLINE DCOM- 20250210 LR - 20261010 IS - 1559-0100 (Electronic) IS - 1355-008X (Linking) VI - 87 IP - 2 DP - 2025 Feb TI - Evaluation of testicular volume in males with congenital hypogonadotropic hypogonadism: a comparative analysis. PG - 836-841 LID - 10.1007/s12020-024-04032-7 [doi] AB - INTRODUCTION: Estimating accurate testicular volume (TV) of congenital hypogonadotropic hypogonadism (CHH) individuals is challenging due to the typically small testicular size. Ultrasound (USG) emerges as a vital solution, enabling precise measurements and reproducible results. The purpose of the study was to assess the three-dimensional measurement of the testis using USG and its volume was estimated using Ellipsoid (E) and Lambert (L) formulae and compared these with the TV by Prader orchidometer (OrTV). METHODS: This is an exploratory analysis of data taken from a clinical trial conducted from May 2022 to March 2024 which included 94 testes from 47 CHH participants. The OrTVs and USGTVs were assessed at baseline and every three months till the completion of the study making a total of 348 observations. The three-dimensional measurement of the testes was noted and TVs were calculated using the above formulae. RESULTS: The mean age of the participants was 25.8 +/- 6.14 years with a mean height of 169.9 +/- 8.42 cm and body mass index (BMI) of 22.4 +/- 4.72 kg/m(2). The baseline mean OrTV, USGTV(E) and USGTV(L) were 2.15 +/- 0.79 ml, 0.69 +/- 0.43 ml and 0.93 +/- 0.59 ml respectively. The smallest OrTV observed was 1 ml with its respective mean USGTV of 0.41 +/- 0.2 ml(E) and 0.56 +/- 0.27 ml(L). An OrTV of 4 ml had a mean USGTV of 1.11 +/- 0.42 ml(E) and 1.51 +/- 9.57 ml(L). At spermatogenesis, the mean OrTV was 8.84 +/- 3.13 ml with the USGTV determined to be 4 +/- 1.46 ml(E) and 5.46 +/- 1.99 ml(L). CONCLUSION: The study revealed that all CHH patients at diagnosis had OrTV < 4 ml. This corresponds to a USG TV cut-off of 1.11 ml using the Ellipsoid formula and 1.51 ml with the Lambert formula, which could serve as a USG diagnostic criterion for CHH. CI - (c) 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Devi, Konsam Biona AU - Devi KB AD - Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. FAU - Gorsi, Ujjwal AU - Gorsi U AD - Department of Radiodiagnosis, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. FAU - Lal, Anupam AU - Lal A AD - Department of Radiodiagnosis, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. FAU - Saini, Shubham AU - Saini S AD - Department of Radiodiagnosis, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. FAU - Jerath, Akhil AU - Jerath A AD - Department of Radiodiagnosis, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. FAU - Thingujam, Dorendro AU - Thingujam D AD - Department of Cardiothoracic and Vascular Surgery, RIMS, Imphal, India. FAU - Baruah, Mintu Mani AU - Baruah MM AD - Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. FAU - Walia, Rama AU - Walia R AD - Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. ramawaliapgimer@gmail.com. LA - eng PT - Comparative Study PT - Journal Article DEP - 20240925 PL - United States TA - Endocrine JT - Endocrine JID - 9434444 SB - IM MH - Humans MH - Male MH - *Testis/diagnostic imaging/pathology MH - Adult MH - *Hypogonadism/congenital/pathology/diagnostic imaging MH - Young Adult MH - Ultrasonography MH - Organ Size MH - Adolescent OTO - NOTNLM OT - Hypogonadotropic hypogonadism OT - Orchidometer OT - Testicular volume OT - USG COIS- Compliance with ethical standards. Conflict of interest: The authors declare no competing interests. Ethical approval: Institutional ethics committee approval was obtained (INT/IEC/2022/SPL-521). Informed consent: Written informed consent for enrollment was obtained from participants or their relatives as applicable. EDAT- 2024/09/25 12:45 MHDA- 2025/02/10 18:16 CRDT- 2024/09/25 11:19 PHST- 2024/05/11 00:00 [received] PHST- 2024/09/03 00:00 [accepted] PHST- 2025/02/10 18:16 [medline] PHST- 2024/09/25 12:45 [pubmed] PHST- 2024/09/25 11:19 [entrez] AID - 10.1007/s12020-024-04032-7 [pii] AID - 10.1007/s12020-024-04032-7 [doi] PST - ppublish SO - Endocrine. 2025 Feb;87(2):836-841. doi: 10.1007/s12020-024-04032-7. Epub 2024 Sep 25. PMID- 39320369 OWN - NLM STAT- MEDLINE DCOM- 20241014 LR - 20241014 IS - 2042-650X (Electronic) IS - 2042-6496 (Linking) VI - 15 IP - 20 DP - 2024 Oct 14 TI - Development of a food frequency questionnaire for the estimation of dietary (poly)phenol intake. PG - 10414-10433 LID - 10.1039/d4fo03546a [doi] AB - Background: (Poly)phenol intake has been associated with reduced risk of non-communicable diseases in epidemiological studies. However, there are currently no dietary assessment tools specifically developed to estimate (poly)phenol intake in the UK population. Objectives: This study aimed to develop a novel food frequency questionnaire (FFQ) to capture the dietary (poly)phenol intake in the UK and assess its relative validity with 7 day diet diaries (7DDs) and plasma and urine (poly)phenol metabolites. Methods: The KCL (poly)phenol FFQ (KP-FFQ) was developed based on the existing EPIC (European Prospective Investigation into Diet and Cancer)-Norfolk FFQ, which has been validated for energy and nutrient intake estimation in the UK population. Participants aged 18-29 years (n = 255) completed both the KP-FFQ and the EPIC-Norfolk FFQ. In a subgroup (n = 60), 7DD, spot urine, and fasting plasma samples were collected. An in-house (poly)phenol database was used to estimate (poly)phenol intake from FFQs and 7DDs. Plasma and urinary (poly)phenol metabolite levels were analysed using a validated ultra-high-performance liquid chromatography-triple quadrupole mass spectrometry method. The agreements between (poly)phenol intake estimated using the KP-FFQ, EPIC-Norfolk FFQ and 7DDs, as well as plasma and urinary biomarkers, were evaluated by intraclass correlation coefficients (ICC), weighted kappa, quartile cross-classification, and Spearman's correlations, and the associations were investigated using linear regression models adjusting for energy intake and multiple testing (false discovery rate (FDR) < 0.05). Results: The mean (standard deviation, SD) of total (poly)phenol intake estimated from KP-FFQs was 1366.5 (1151.7) mg d(-1). Fair agreements were observed between ten (poly)phenol groups estimated from KP-FFQs and 7DDs (kappa: 0.41-0.73), including total (poly)phenol intake (kappa = 0.45), while the agreements for the rest of the 17 classes and subclasses were poor (kappa: 0.07-0.39). Strong positive associations with KP-FFQ were found in ten (poly)phenols estimated from 7DDs, including dihydroflavonols, theaflavins, thearubigins, flavones, isoflavonoids, ellagitannins, hydroxyphenylacetic acids, total stilbenes, resveratrol, and tyrosols with stdBeta ranged from 0.61 (95% confidence interval CI: 0.42 to 0.81) to 0.95 (95% CI: 0.86 to 1.03) (all FDR adjusted p < 0.05). KP-FFQs estimated (poly)phenol intake exhibited positive associations with 76 urinary metabolites (stdBeta: 0.28 (95% CI: 0.07-0.49) to 0.81 (0.62-1.00)) and 19 plasma metabolites (stdBeta: 0.40 (0.17-0.62)-0.83 (0.64-1.02)) (all FDR p < 0.05). The agreement between KP-FFQs and the EPIC-Norfolk FFQs was moderate (ICC 0.51-0.69) for all (poly)phenol subclasses after adjusting for energy intake. Compared with the EPIC-Norfolk FFQs estimated (poly)phenol intake, stronger and more agreements and associations were found in KP-FFQs estimated (poly)phenol with 7DDs and biomarkers. Conclusion: (Poly)phenol intake estimated from KP-FFQ exhibited fair agreements and moderate to strong associations with 7DDs and biomarkers, indicating the novel questionnaire may be a promising tool to assess dietary (poly)phenol intake. FAU - Li, Yong AU - Li Y AD - Department of Nutritional Sciences, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK. ana.rodriguez-mateos@kcl.ac.uk. FAU - Xu, Yifan AU - Xu Y AUID- ORCID: 0000-0002-8999-2565 AD - Department of Nutritional Sciences, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK. ana.rodriguez-mateos@kcl.ac.uk. FAU - Le Sayec, Melanie AU - Le Sayec M AD - Department of Nutritional Sciences, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK. ana.rodriguez-mateos@kcl.ac.uk. FAU - Kamarunzaman, Nur Najiah Zaidani AU - Kamarunzaman NNZ AD - Department of Nutritional Sciences, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK. ana.rodriguez-mateos@kcl.ac.uk. FAU - Wu, Haonan AU - Wu H AD - Department of Nutritional Sciences, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK. ana.rodriguez-mateos@kcl.ac.uk. FAU - Hu, Jiaying AU - Hu J AD - Department of Nutritional Sciences, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK. ana.rodriguez-mateos@kcl.ac.uk. FAU - Li, Shan AU - Li S AD - Department of Nutritional Sciences, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK. ana.rodriguez-mateos@kcl.ac.uk. FAU - Gibson, Rachel AU - Gibson R AD - Department of Nutritional Sciences, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK. ana.rodriguez-mateos@kcl.ac.uk. FAU - Rodriguez-Mateos, Ana AU - Rodriguez-Mateos A AUID- ORCID: 0000-0003-3242-402X AD - Department of Nutritional Sciences, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK. ana.rodriguez-mateos@kcl.ac.uk. LA - eng PT - Journal Article DEP - 20241014 PL - England TA - Food Funct JT - Food & function JID - 101549033 RN - 0 (Polyphenols) SB - IM MH - Humans MH - Adult MH - Female MH - Male MH - Young Adult MH - Adolescent MH - Surveys and Questionnaires MH - *Diet MH - Polyphenols/urine/blood MH - United Kingdom MH - Diet Surveys MH - Diet Records EDAT- 2024/09/25 16:18 MHDA- 2024/10/14 19:00 CRDT- 2024/09/25 10:53 PHST- 2024/10/14 19:00 [medline] PHST- 2024/09/25 16:18 [pubmed] PHST- 2024/09/25 10:53 [entrez] AID - 10.1039/d4fo03546a [doi] PST - epublish SO - Food Funct. 2024 Oct 14;15(20):10414-10433. doi: 10.1039/d4fo03546a. PMID- 39318111 OWN - NLM STAT- MEDLINE DCOM- 20241107 LR - 20260514 IS - 1520-6300 (Electronic) IS - 1042-0533 (Linking) VI - 36 IP - 11 DP - 2024 Nov TI - Exploring the Relationship Between Stress, Salivary C-Reactive Protein, and Embodied Physiological Responses in a Nigerian Population. PG - e24158 LID - 10.1002/ajhb.24158 [doi] AB - OBJECTIVES: The impacts of stress on inflammation, although hypothesized, have not been thoroughly examined, especially in relation to social and environmental factors and particularly within Black populations. This study aims to explore the biological mechanisms of embodiment linking stress and health to understand physiological changes in the body's response to psychological stress in a Nigerian population. Through a multidisciplinary approach, this study queries the relationship between stress, cortisol, and salivary C-reactive protein (sCRP), a biomarker of inflammation, while also validating the use of sCRP as a potential and accurate stress indicator in the field. METHODS: In this cross-sectional study, 138 passive drool saliva samples (n (female) = 89 n (male) = 49) were collected and assessed for sCRP and cortisol levels in adults. Participants also completed a short demographic survey and, to measure psychological stress, the General Health Questionnaire 12 (GHQ-12). Relationships between sCRP and stress-related variables (i.e., cortisol, GHQ-12, and demographic data) were assessed using Spearman's correlations, simple regression, multivariable linear regression, and exploratory factor analysis. RESULTS: sCRP levels ranged from 20.57 to 6879.41 pg/mL across all samples, with significant differences between female and male participants. The GHQ-12 was not a significant predictor of sCRP variability. However, socio-demographic factors such as body mass index (BMI), age, self-reported sex, ethnic identity, and cortisol were significant predictors, collectively explaining 24%-27% of the variation in sCRP. CONCLUSION: Socio-demographic predictors like BMI, age, sex, and particularly ethnic group experience in Nigeria encapsulate aspects of embodied stress, that significantly affect sCRP variability. CI - (c) 2024 The Author(s). American Journal of Human Biology published by Wiley Periodicals LLC. FAU - Winful, Taiye AU - Winful T AUID- ORCID: 0000-0003-0266-4313 AD - Department of Anthropology, Genetic Anthropology and Biocultural Studies Laboratory, Vanderbilt University, Nashville, Tennessee, USA. AD - Department of Anthropology, University of Illinois Urbana Champaign, Champaign, Illinois, USA. FAU - Sorunke, Modupe AU - Sorunke M AD - Department of Preventive Dentistry, Lagos State University College of Medicine (LASUCOM), Ikeja-Lagos, Nigeria. FAU - Benn Torres, Jada AU - Benn Torres J AD - Department of Anthropology, Genetic Anthropology and Biocultural Studies Laboratory, Vanderbilt University, Nashville, Tennessee, USA. LA - eng GR - 2235572/National Science Foundation/ PT - Journal Article PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20240924 PL - United States TA - Am J Hum Biol JT - American journal of human biology : the official journal of the Human Biology Council JID - 8915029 RN - 9007-41-4 (C-Reactive Protein) RN - WI4X0X7BPJ (Hydrocortisone) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Male MH - Nigeria MH - Female MH - *Saliva/chemistry MH - *Stress, Psychological MH - *C-Reactive Protein/analysis/metabolism MH - Adult MH - Cross-Sectional Studies MH - Middle Aged MH - *Hydrocortisone/analysis/metabolism MH - Young Adult MH - Biomarkers/analysis/metabolism MH - Adolescent MH - Aged OTO - NOTNLM OT - GHQ-12 OT - Nigerian populations OT - cortisol OT - embodiment OT - inflammation OT - salivary C-reactive protein OT - social stress EDAT- 2024/09/25 10:18 MHDA- 2024/11/07 06:23 CRDT- 2024/09/25 01:43 PHST- 2024/09/02 00:00 [revised] PHST- 2024/05/10 00:00 [received] PHST- 2024/09/07 00:00 [accepted] PHST- 2024/11/07 06:23 [medline] PHST- 2024/09/25 10:18 [pubmed] PHST- 2024/09/25 01:43 [entrez] AID - 10.1002/ajhb.24158 [doi] PST - ppublish SO - Am J Hum Biol. 2024 Nov;36(11):e24158. doi: 10.1002/ajhb.24158. Epub 2024 Sep 24. PMID- 39316483 OWN - NLM STAT- MEDLINE DCOM- 20250424 LR - 20250522 IS - 1558-2531 (Electronic) IS - 0018-9294 (Linking) VI - 72 IP - 2 DP - 2025 Feb TI - Active Vibrational Achilles Tendon Sensing for Identifying and Characterizing Inflammatory Symptomatology in Enthesitis Related Arthritis. PG - 645-654 LID - 10.1109/TBME.2024.3466831 [doi] AB - OBJECTIVE: This study explores the potential of active vibrational sensing as a digital biomarker to identify and characterize inflammatory symptomatology in the Achilles tendon and its entheses in juvenile idiopathic arthritis (JIA), particularly enthesitis related arthritis (ERA), a subcategory of JIA. METHODS: Active vibrational data were non-invasively recorded using a miniature coin vibration motor and accelerometer. Twenty active vibration recordings from children diagnosed with JIA were used in the analysis. Machine learning algorithms were leveraged to classify the vibrational signatures according to the corresponding subject groups. Subjects were classified into symptomatic ERA (sxERA), asymptomatic ERA (asxERA), and asymptomatic JIA (non-ERA) (asxNERA) groups based on clinical evaluations and ILAR criteria. RESULTS: Distinct vibrational signatures were observed during tiptoe standing, providing differentiation between subject groups. Feature-based and waveform-based approaches effectively classified the sxERA group against asxNERA and asxERA groups using leave-one-subject-out (LOSO-CV) and 3-fold cross-validation. For the 3-fold cross-validation, the mean accuracies for distinguishing sxERA from asxNERA were 81% (feature-based) and 81% (waveform-based), while the accuracies for discriminating sxERA against asxERA were 73% (feature-based) and 74% (waveform-based). CONCLUSION: Active vibrational sensing demonstrates promise as a tool for identifying Achilles tendon inflammation in JIA, potentially aiding in early diagnosis and disease monitoring. SIGNIFICANCE: Developing active vibrational sensing as a diagnostic modality could address challenges in diagnosing ERA and facilitate timely intervention and personalized care for JIA, potentially enhancing long-term patient outcomes. FAU - Goossens, Quentin AU - Goossens Q FAU - Locsin, Miguel AU - Locsin M FAU - Ponder, Lori A AU - Ponder LA FAU - Chan, Michael AU - Chan M FAU - Ozmen, Goktug C AU - Ozmen GC FAU - Prahalad, Sampath AU - Prahalad S FAU - Inan, Omer T AU - Inan OT LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20250121 PL - United States TA - IEEE Trans Biomed Eng JT - IEEE transactions on bio-medical engineering JID - 0012737 SB - IM MH - Humans MH - *Achilles Tendon/physiopathology MH - *Vibration MH - *Arthritis, Juvenile/physiopathology/diagnosis MH - Child MH - Male MH - Female MH - *Signal Processing, Computer-Assisted MH - Adolescent MH - Accelerometry/methods MH - *Enthesopathy/diagnosis/physiopathology MH - Machine Learning MH - Algorithms EDAT- 2024/09/24 22:18 MHDA- 2025/03/04 00:22 CRDT- 2024/09/24 12:23 PHST- 2025/03/04 00:22 [medline] PHST- 2024/09/24 22:18 [pubmed] PHST- 2024/09/24 12:23 [entrez] AID - 10.1109/TBME.2024.3466831 [doi] PST - ppublish SO - IEEE Trans Biomed Eng. 2025 Feb;72(2):645-654. doi: 10.1109/TBME.2024.3466831. Epub 2025 Jan 21. PMID- 39316280 OWN - NLM STAT- MEDLINE DCOM- 20250424 LR - 20261010 IS - 1970-9366 (Electronic) IS - 1828-0447 (Linking) VI - 20 IP - 1 DP - 2025 Jan TI - Life-course obesity and heart failure: a two-sample Mendelian randomization study. PG - 171-180 LID - 10.1007/s11739-024-03772-8 [doi] AB - Heart failure is a multifaceted clinical syndrome, with obesity identified as a significant modifiable risk factor. This study employed a two-sample Mendelian randomization (MR) design, incorporating obesity data across life stages, to elucidate the causal link between obesity and heart failure. Data on heart failure from the 2023 Finngen database and genetic predictors of obesity from the IEU OpenGWAS project were analyzed using the IVW method, MR-Egger regression, weighted median, simple mode, weighted mode, and scatter plots. Heterogeneity was assessed with Cochran's Q test, and horizontal pleiotropy with MR-Egger intercept test. Sensitivity to single-nucleotide polymorphisms (SNPs) was tested via leave-one-out analysis, and funnel plots were utilized for visual inspection of horizontal pleiotropy. Statistical powers were also calculated. The MR analysis findings indicate a significant relationship between birth weight and the likelihood of developing heart failure (Odds Ratio [OR] 1.134, 95% Confidence Interval [CI] 1.033-1.245, P = 0.008). In addition, a heightened childhood BMI was found to be a significant predictor of heart failure risk (OR 1.307, 95% CI 1.144-1.494, P = 8.51E-05), as was childhood obesity (OR 1.123, 95% CI 1.074-1.173, P = 2.37E-07). Furthermore, adult BMI sex-combined exhibited a strong correlation with the risk of heart failure (OR 2.365, 95% CI 2.128-2.629, P = 1.91E-57). Sensitivity analyses provided further support for the reliability of these results, with no significant indication of horizontal pleiotropy observed. This study shows that obesity, including childhood obesity, is linked to a higher risk of heart failure. These findings highlight the urgent need for early weight management interventions in public health and clinical settings to reduce heart failure rates. CI - (c) 2024. The Author(s), under exclusive licence to Societa Italiana di Medicina Interna (SIMI). FAU - Wang, Haili AU - Wang H AUID- ORCID: 0000-0002-0310-8143 AD - Department of Obstetrics and Gynecology, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, 313000, China. AD - Fifth School of Clinical Medicine of Zhejiang, Huzhou Central Hospital, Chinese Medical University, Huzhou, 313000, China. FAU - Min, Jie AU - Min J AUID- ORCID: 0000-0002-7629-5541 AD - Department of Intensive Care Unit, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, 313000, China. AD - Fifth School of Clinical Medicine of Zhejiang, Huzhou Central Hospital, Chinese Medical University, Huzhou, 313000, China. FAU - Zhong, Lei AU - Zhong L AUID- ORCID: 0000-0002-0208-1823 AD - Department of Intensive Care Unit, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, 313000, China. AD - Fifth School of Clinical Medicine of Zhejiang, Huzhou Central Hospital, Chinese Medical University, Huzhou, 313000, China. FAU - Zhang, Jinyu AU - Zhang J AUID- ORCID: 0000-0002-9200-5348 AD - Department of General Surgery, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, 313000, China. AD - Fifth School of Clinical Medicine of Zhejiang, Huzhou Central Hospital, Chinese Medical University, Huzhou, 313000, China. FAU - Ye, Lili AU - Ye L AD - Department of Intensive Care Unit, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, 313000, China. AD - Fifth School of Clinical Medicine of Zhejiang, Huzhou Central Hospital, Chinese Medical University, Huzhou, 313000, China. FAU - Chen, Chunrong AU - Chen C AD - Department of Pediatrics, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, 313000, China. ccr209418@163.com. AD - Fifth School of Clinical Medicine of Zhejiang, Huzhou Central Hospital, Chinese Medical University, Huzhou, 313000, China. ccr209418@163.com. LA - eng GR - 2022GY20/the Science and Technology Program of Huzhou/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240924 PL - Italy TA - Intern Emerg Med JT - Internal and emergency medicine JID - 101263418 SB - IM MH - Humans MH - *Heart Failure/epidemiology/genetics/etiology MH - Mendelian Randomization Analysis/methods MH - *Obesity/complications/epidemiology/genetics MH - Male MH - Female MH - Risk Factors MH - Body Mass Index MH - Polymorphism, Single Nucleotide MH - Adult MH - Middle Aged OTO - NOTNLM OT - Body mass index OT - Heart failure OT - Life-course obesity OT - Mendelian randomization COIS- Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval and informed consent: Only publicly available data were used for this study. Ethical approval for all data used can be found in the original publication. Consent for publication: Not applicable. EDAT- 2024/09/24 12:44 MHDA- 2025/02/05 06:21 CRDT- 2024/09/24 11:22 PHST- 2024/07/12 00:00 [received] PHST- 2024/09/08 00:00 [accepted] PHST- 2025/02/05 06:21 [medline] PHST- 2024/09/24 12:44 [pubmed] PHST- 2024/09/24 11:22 [entrez] AID - 10.1007/s11739-024-03772-8 [pii] AID - 10.1007/s11739-024-03772-8 [doi] PST - ppublish SO - Intern Emerg Med. 2025 Jan;20(1):171-180. doi: 10.1007/s11739-024-03772-8. Epub 2024 Sep 24. PMID- 39315061 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20251020 IS - 2667-3681 (Electronic) IS - 2667-3681 (Linking) VI - 12 DP - 2024 Dec TI - Reliable prediction of childhood obesity using only routinely collected EHRs may be possible. PG - 100128 LID - 10.1016/j.obpill.2024.100128 [doi] LID - 100128 AB - BACKGROUND: Early identification of children at high risk of obesity can provide clinicians with the information needed to provide targeted lifestyle counseling to high-risk children at a critical time to change the disease course. OBJECTIVES: This study aimed to develop predictive models of childhood obesity, applying advanced machine learning methods to a large unaugmented electronic health record (EHR) dataset. This work improves on other studies that have (i) relied on data not routinely available in EHRs (like prenatal data), (ii) focused on single-age predictions, or (iii) not been rigorously validated. METHODS: A customized sequential deep-learning model to predict the development of obesity was built, using EHR data from 36,191 diverse children aged 0-10 years. The model was evaluated using extensive discrimination, calibration, and utility analysis; and was validated temporally, geographically, and across various subgroups. RESULTS: Our results are mostly better or comparable to similar studies. Specifically, the model achieved an AUROC above 0.8 in all cases (with most cases around 0.9) for predicting obesity within the next 3 years for children 2-7 years of age. Validation results show the model's robustness and top predictors match important risk factors of obesity. CONCLUSIONS: Our model can predict the risk of obesity for young children at multiple time points using only routinely collected EHR data, greatly facilitating its integration into clinical care. Our model can be used as an objective screening tool to provide clinicians with insights into a patient's risk for developing obesity so that early lifestyle counseling can be provided to prevent future obesity in young children. CI - (c) 2024 The Author(s). FAU - Gupta, Mehak AU - Gupta M AD - Southern Methodist University, Dallas, TX, USA. FAU - Eckrich, Daniel AU - Eckrich D AD - Nemours Children's Health, Wilmington, DE, USA. FAU - Bunnell, H Timothy AU - Bunnell HT AD - Nemours Children's Health, Wilmington, DE, USA. FAU - Phan, Thao-Ly T AU - Phan TT AD - Nemours Children's Health, Wilmington, DE, USA. FAU - Beheshti, Rahmatollah AU - Beheshti R AD - University of Delaware, Newark, DE, USA. LA - eng GR - P20 GM103446/GM/NIGMS NIH HHS/United States GR - U54 GM104941/GM/NIGMS NIH HHS/United States PT - Journal Article DEP - 20240910 PL - United States TA - Obes Pillars JT - Obesity pillars JID - 9918697364706676 PMC - PMC11417568 OTO - NOTNLM OT - Childhood obesity OT - Deep learning OT - Electronic health records COIS- The authors declare no competing financial interests. EDAT- 2024/09/24 10:19 MHDA- 2024/09/24 10:20 PMCR- 2024/09/10 CRDT- 2024/09/24 04:48 PHST- 2024/05/26 00:00 [received] PHST- 2024/08/21 00:00 [revised] PHST- 2024/08/22 00:00 [accepted] PHST- 2024/09/24 10:20 [medline] PHST- 2024/09/24 10:19 [pubmed] PHST- 2024/09/24 04:48 [entrez] PHST- 2024/09/10 00:00 [pmc-release] AID - S2667-3681(24)00030-5 [pii] AID - 100128 [pii] AID - 10.1016/j.obpill.2024.100128 [doi] PST - epublish SO - Obes Pillars. 2024 Sep 10;12:100128. doi: 10.1016/j.obpill.2024.100128. eCollection 2024 Dec. PMID- 39314592 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240925 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 16 IP - 8 DP - 2024 Aug TI - Prevalence of Varicose Veins Among Surgeons: A Cross-Sectional Study. PG - e67687 LID - 10.7759/cureus.67687 [doi] LID - e67687 AB - Background Extended periods of standing, obesity, female sex, and older age are risk factors associated with a higher probability of developing varicose veins (VV). This study aimed to determine the prevalence of VV among surgeons in public hospitals in Makkah, Saudi Arabia, and to identify the risk factors associated with this condition. Methodology This is a descriptive cross-sectional study based on a validated online questionnaire distributed via hospital WhatsApp (Meta Platforms Inc., Menlo Park, CA) groups conducted between January and June 2024. The inclusion criteria of this study were surgeons of both sexes and any age group working in the selected hospitals in Makkah City, who agreed to participate in the study. The exclusion criteria were any other healthcare workers from outside the surgical field. We included 192 participants, and Epi Info software (Centers for Disease Control and Prevention, Atlanta, GA) was used to calculate the sample size. The data were collected, reviewed, and then fed into IBM SPSS Statistics software for Windows version 21 (IBM Corp., Armonk, NY). Every participant filled out a consent form. The university ethics committee of Umm Al-Qura University, Makkah, granted ethical permission. Result This study comprised 192 surgeons in Makkah hospitals. Twenty-eight surgeons were either diagnosed with VV or had signs of VV. Varicose veins were detected among 50% of thoracic surgeons, 42.9% of pediatric surgeons, and 26.3% of orthopedic surgeons. The most reported risk factors were a family history of VV (17%), hypertension (16%), and diabetes mellitus (14%). Surgeons aged 40 years or older had a higher prevalence of VV than younger ones. Also, 55.6% of obese surgeons had VV compared to 7.8% of others with average weight. Conclusion We found that VV is a common problem, particularly among individuals with predisposing factors, such as long standing hours, smoking, pregnancy, and obesity. We found that surgeons specializing in thoracic and pediatric specialties and female surgeons were more likely to be affected by VV. Preventive measures, such as avoiding prolonged standing, wearing compression stockings, and maintaining a healthy lifestyle, are recommended. CI - Copyright (c) 2024, Qari et al. FAU - Qari, Turki A AU - Qari TA AD - Medicine and Surgery, Umm Al-Qura University, Makkah, SAU. FAU - Almatrafi, Khaled N AU - Almatrafi KN AD - Medicine and Surgery, Umm Al-Qura University, Makkah, SAU. FAU - Khateb, Fawaz R AU - Khateb FR AD - Medicine and Surgery, Umm Al-Qura University, Makkah, SAU. FAU - Al-Kaabi, Bader AU - Al-Kaabi B AD - Medicine and Surgery, Umm Al-Qura University, Makkah, SAU. FAU - Al-Harbi, Ahmed AU - Al-Harbi A AD - Medicine and Surgery, Umm Al-Qura University, Makkah, SAU. FAU - Alabdali, Samer AU - Alabdali S AD - Medicine and Surgery, Umm Al-Qura University, Makkah, SAU. FAU - Al-Nemari, Rashed AU - Al-Nemari R AD - Medicine and Surgery, Umm Al-Qura University, Makkah, SAU. FAU - Bannani, Sahar A AU - Bannani SA AD - Surgery, Umm Al-Qura University, Makkah, SAU. AD - Surgical Oncology, King Abdullah Medical City, Makkah, SAU. LA - eng PT - Journal Article DEP - 20240824 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC11419730 OTO - NOTNLM OT - general surgery OT - prevalence OT - surgeons OT - varicose veins OT - vascular surgery COIS- Human subjects: Consent was obtained or waived by all participants in this study. Umm Al-Qura University's Biomedical Research Ethics Committee issued approval (HAPO-02-K-012-2023-09-1733). Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2024/09/24 10:19 MHDA- 2024/09/24 10:20 PMCR- 2024/08/24 CRDT- 2024/09/24 04:40 PHST- 2024/08/24 00:00 [accepted] PHST- 2024/09/24 10:20 [medline] PHST- 2024/09/24 10:19 [pubmed] PHST- 2024/09/24 04:40 [entrez] PHST- 2024/08/24 00:00 [pmc-release] AID - 10.7759/cureus.67687 [doi] PST - epublish SO - Cureus. 2024 Aug 24;16(8):e67687. doi: 10.7759/cureus.67687. eCollection 2024 Aug. PMID- 39314518 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240925 IS - 2055-7647 (Print) IS - 2055-7647 (Electronic) IS - 2055-7647 (Linking) VI - 10 IP - 3 DP - 2024 TI - Are perceived barriers to physical activity related to depression, anxiety and stress among adolescents? The EHDLA study. PG - e002069 LID - 10.1136/bmjsem-2024-002069 [doi] LID - e002069 AB - OBJECTIVE: The aim of this study was twofold: first, to examine the association between perceived barriers to physical activity (PA) practice and depression, anxiety and stress in a sample of Spanish adolescents; and second, to determine which barriers are specifically associated with depression, anxiety and stress. METHODS: This cross-sectional study was conducted with 765 adolescents aged 12-17 (55.6% girls) in the Valle of Ricote, Murcia, Spain. Depression, anxiety and stress symptoms were assessed using the Depression, Anxiety and Stress Scale (DASS-21), with validated cut points employed to determine the presence of each of these mental conditions. The perception of barriers to PA was assessed using a validated questionnaire for the Spanish adolescent population. RESULTS: The barrier 'Because I feel that my physical appearance is worse than that of others' was related to a higher likelihood of having depression (OR=2.41; 95% CI 1.35 to 4.28; p=0.003), anxiety (OR=2.65; 95% CI 1.51 to 4.71; p=0.001) and stress (OR=2.82; 95% CI 1.59 to 5.07; p<0.001). Similarly, the barrier 'Because nobody encourages me to engage in physical activity' was related to a higher likelihood of having depression (OR=1.92; 95% CI 1.08 to 3.43; p=0.026), anxiety (OR=1.97; 95% CI 1.11 to 3.50; p=0.021) and stress (OR=1.99; 95% CI 1.12 to 3.59; p=0.021). CONCLUSION: Perceived barriers to PA related to physical appearance and social support seem to be associated with a greater likelihood of depression, anxiety and stress among Spanish adolescents. CI - Copyright (c) Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. FAU - de Camargo, Edina Maria AU - de Camargo EM AD - Department of Physical Education, Universidade Federal do Parana, Curitiba, Brazil. FAU - Chen, Sitong AU - Chen S AD - Institute for Health and Sport, Victoria University, Melbourne, Victoria, Australia. FAU - Lopez-Bueno, Ruben AU - Lopez-Bueno R AD - Department of Physical Medicine and Nursing, University of Zaragoza, Zaragoza, Spain. FAU - Mesas, Arthur Eumann AU - Mesas AE AD - Health and Social Research Center, Universidad de Castilla-La Mancha, Cuenca, Spain. FAU - Bizzozero-Peroni, Bruno AU - Bizzozero-Peroni B AD - Health and Social Research Center, Universidad de Castilla-La Mancha, Cuenca, Spain. AD - Higher Institute of Physical Education, Universidad de la Republica, Rivera, Uruguay. FAU - Martin-Calvo, Nerea AU - Martin-Calvo N AD - IdiSNA, Instituto de Investigacion Sanitaria de Navarra, Pamplona, Spain. AD - Department of Preventive Medicine and Public Health, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain. AD - Pathophysiology of Obesity and Nutrition, Centro de Investigacion Biomedica en Red, Instituto de Salud Carlos III, Madrid, Spain. FAU - Jimenez-Lopez, Estela AU - Jimenez-Lopez E AD - Health and Social Research Center, Universidad de Castilla-La Mancha, Cuenca, Spain. AD - Centro de Investigacion Biomedica en Red de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AUID- ORCID: 0000-0002-7412-7624 AD - One Health Research Group, Universidad de Las Americas, Quito, Ecuador. LA - eng PT - Journal Article DEP - 20240923 PL - England TA - BMJ Open Sport Exerc Med JT - BMJ open sport & exercise medicine JID - 101681007 PMC - PMC11418574 OTO - NOTNLM OT - Anxiety OT - Depression OT - Physical activity OT - Stress OT - Well-being COIS- None declared. EDAT- 2024/09/24 06:55 MHDA- 2024/09/24 06:56 PMCR- 2024/09/23 CRDT- 2024/09/24 04:39 PHST- 2024/09/01 00:00 [accepted] PHST- 2024/09/24 06:56 [medline] PHST- 2024/09/24 06:55 [pubmed] PHST- 2024/09/24 04:39 [entrez] PHST- 2024/09/23 00:00 [pmc-release] AID - bmjsem-2024-002069 [pii] AID - 10.1136/bmjsem-2024-002069 [doi] PST - epublish SO - BMJ Open Sport Exerc Med. 2024 Sep 23;10(3):e002069. doi: 10.1136/bmjsem-2024-002069. eCollection 2024. PMID- 39313756 OWN - NLM STAT- MEDLINE DCOM- 20240924 LR - 20260702 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 27 IP - 1 DP - 2024 Sep 24 TI - Association between dietary intake of carotenoids and metabolic dysfunction-associated fatty liver disease in US adults: National Health and Nutrition Examination Survey 2017-March 2020. PG - e168 LID - 10.1017/S1368980024001502 [doi] LID - e168 AB - OBJECTIVE: To assess the relationship between dietary intake of alpha-carotene, beta-carotene, beta-cryptoxanthin, lycopene and lutein+zeaxanthin (LZ) and occurrence of metabolic dysfunction-associated fatty liver disease (MAFLD). DESIGN: Cross-sectional study design. The MAFLD diagnosis was based on hepatic steatosis and metabolic dysregulation. Carotenoid intake was adjusted for using an energy-adjusted model. Logistic regression and restricted cubic spline (RCS) analyses were used to assess the relationships, with sensitivity analysis to validate the findings. Weighted quantile sum regression (WQS) was used to explore the combined effect of these carotenoids on MAFLD. Subgroup analyses were conducted to identify population-specific associations. SETTING: National Health and Nutrition Examination Survey (NHANES) 2017-March 2020. PARTICIPANTS: This study included 5098 individuals aged 18 years and older. RESULTS: After adjusting for potential confounders, a weak inverse association was observed between alpha-carotene and beta-carotene intakes and MAFLD occurrence (all P value <0.05). The highest quartile of beta-carotene intake showed a significantly lower occurrence of MAFLD compared with the lowest quartile (OR = 0.65; 95 % CI: 0.44, 0.97). RCS analysis showed that a significantly lower occurrence of MAFLD was associated with a higher intake of the four carotenoids, excluding lycopene. Furthermore, the WQS analysis revealed a negative relationship between combined carotenoid intake and MAFLD occurrence (OR = 0.95, 95 % CI: 0.90, 1.00, P = 0.037). Subgroup analyses showed dietary carotenoid intake was associated with reduced MAFLD occurrence in populations aged 50-69 years, females, physically active individuals and non-drinkers. CONCLUSION: Higher dietary intake of carotenoids is associated with lower MAFLD occurrence. However, this relationship varies among individuals of different ages, sexes and lifestyles. FAU - Yu, Jiahui AU - Yu J AD - The Center of Gastrointestinal and Minimally Invasive Surgery, Department of General Surgery, The Third People's Hospital of Chengdu/The Affiliated Hospital of Southwest Jiaotong University, Chengdu, People's Republic of China. FAU - Guo, Peisen AU - Guo P AD - The Center of Gastrointestinal and Minimally Invasive Surgery, Department of General Surgery, The Third People's Hospital of Chengdu/The Affiliated Hospital of Southwest Jiaotong University, Chengdu, People's Republic of China. LA - eng PT - Journal Article DEP - 20240924 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 RN - 36-88-4 (Carotenoids) RN - 45XWE1Z69V (alpha-carotene) RN - 01YAE03M7J (beta Carotene) SB - IM MH - Humans MH - *Carotenoids/administration & dosage MH - Male MH - Female MH - Cross-Sectional Studies MH - Middle Aged MH - Adult MH - *Nutrition Surveys/statistics & numerical data MH - United States/epidemiology MH - *Diet/statistics & numerical data/methods MH - Aged MH - Young Adult MH - Fatty Liver/epidemiology/etiology MH - beta Carotene/administration & dosage MH - Adolescent MH - Non-alcoholic Fatty Liver Disease/epidemiology/etiology PMC - PMC11504986 OTO - NOTNLM OT - Carotenoids OT - Dietary intake OT - Metabolic dysfunction-associated fatty liver disease OT - National Health and Nutrition Examination Survey COIS- None. EDAT- 2024/09/24 00:42 MHDA- 2024/09/24 18:51 PMCR- 2024/09/24 CRDT- 2024/09/23 23:24 PHST- 2024/09/24 18:51 [medline] PHST- 2024/09/24 00:42 [pubmed] PHST- 2024/09/23 23:24 [entrez] PHST- 2024/09/24 00:00 [pmc-release] AID - S1368980024001502 [pii] AID - 10.1017/S1368980024001502 [doi] PST - epublish SO - Public Health Nutr. 2024 Sep 24;27(1):e168. doi: 10.1017/S1368980024001502. PMID- 39313207 OWN - NLM STAT- MEDLINE DCOM- 20250515 LR - 20250613 IS - 1439-359X (Electronic) IS - 0939-7248 (Linking) VI - 35 IP - 3 DP - 2025 Jun TI - Physical Activity Levels in Children with Esophageal Atresia and Congenital Heart Disease: A Comparative Multicenter Study. PG - 171-179 LID - 10.1055/a-2420-0202 [doi] AB - AIM OF THE STUDY: Esophageal atresia (EA) is associated with impaired motor development, cardiopulmonary function, and physical activity (PA). Despite missing scientific evidence, this fact is often attributed to associated congenital heart disease (CHD). The aim of this study was to investigate PA in EA patients without CHD compared with CHD patients and healthy controls. METHODS: In this multicenter study, EA patients aged 6 through 17 years were included. Moderate-to-vigorous PA (MVPA, minutes per week) was assessed using the standardized and validated questionnaire Motorik-Modul Physical Activity Questionnaire. EA patients were randomly matched 1:4 for gender and age with patients with CHD (n = 1,262) and healthy controls (n = 6,233). Patients born with both EA and CHD were excluded. Means and 95% confidence intervals (95% CIs) were calculated. To identify associated factors, Spearman's correlation was performed. MAIN RESULTS: Overall, 69 EA patients were matched with 276 CHD patients and 276 controls (57% male, 43% female, mean age 10,3 years, 95% CI: 9.5-11.1). Mean MVPA was reduced in EA (492 minutes, 95% CI: 387-598) and CHD patients (463 minutes, 95% CI: 416-511) compared with controls (613 minutes, 95% CI: 548-679). In subgroup analysis, MVPA was reduced further in females and older age groups with EA and CHD. For EA patients, there was no statistical association between Gross type, current symptoms, surgical approaches, and MVPA. CONCLUSION: Isolated EA and CHD were associated with reduced PA, especially in females and teenagers. To avoid additional morbidity associated with sedentary behavior, PA should be promoted during follow-up. CI - Thieme. All rights reserved. FAU - Frankenbach, Luisa Maria AU - Frankenbach LM AD - Department of Pediatric Surgery, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Rheinland-Pfalz, Germany. FAU - Holler, Anne-Sophie AU - Holler AS AD - Department of Pediatric Surgery at Dr von Hauner Children's Hospital, LMU Hospital, Munchen, Bayern, Germany. FAU - Oetzmann von Sochaczewski, Christina AU - Oetzmann von Sochaczewski C AUID- ORCID: 0000-0002-3469-777X AD - Division of Pediatric Surgery, Department of Surgery, University Hospital Bonn, Bonn, Nordrhein-Westfalen, Germany. FAU - Wessel, Lucas AU - Wessel L AD - Department of Pediatric Surgery, University Medical Centre Mannheim, Mannheim, Baden-Wurttemberg, Germany. FAU - Muensterer, Oliver J AU - Muensterer OJ AUID- ORCID: 0000-0003-2790-4395 AD - Department of Pediatric Surgery at Dr von Hauner Children's Hospital, LMU Hospital, Munchen, Bayern, Germany. FAU - Dingemann, Jens AU - Dingemann J AUID- ORCID: 0000-0001-8532-2794 AD - Department of Pediatric Surgery, Hannover Medical School, Hannover, Niedersachsen, Germany. FAU - Widenmann, Anke AU - Widenmann A AD - KEKS e.V., Patient Organisation for Esophageal Diseases, Stuttgart, Germany. FAU - Helm, Paul AU - Helm P AD - National Register of Congenital Heart Defect, Competence Network for Congenital Heart Defects, Berlin, Germany. FAU - Siaplaouras, Jannos AU - Siaplaouras J AD - Department of Health Sciences, Fulda University of Applied Sciences, Fulda, Hessen, Germany. FAU - Bauer, Ulrike AU - Bauer U AD - National Register of Congenital Heart Defect, Competence Network for Congenital Heart Defects, Berlin, Germany. FAU - Apitz, Christian AU - Apitz C AD - Department of Pediatric Cardiology, Ulm University Medical Center, Ulm, Baden-Wurttemberg, Germany. FAU - Niessner, Claudia AU - Niessner C AD - Institute for Sport and Sport Science, Karlsruhe Institute of Technology, Karlsruhe, Baden-Wurttemberg, Germany. FAU - Konig, Tatjana Tamara AU - Konig TT AUID- ORCID: 0000-0001-6994-8252 AD - Department of Pediatric Surgery, Hannover Medical School, Hannover, Niedersachsen, Germany. LA - eng GR - 01GI0601/Competence Network for Congenital Heart Defects/ GR - 01ER1503/Bundesministerium fur Bildung und Forschung/ GR - 01KX2140/National Register for Congenital Heart Defects/ PT - Comparative Study PT - Journal Article PT - Multicenter Study DEP - 20240923 PL - United States TA - Eur J Pediatr Surg JT - European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie JID - 9105263 SB - IM MH - Humans MH - Female MH - Male MH - *Heart Defects, Congenital/complications/physiopathology MH - *Esophageal Atresia/physiopathology/complications MH - Adolescent MH - Child MH - *Exercise MH - Case-Control Studies MH - Surveys and Questionnaires COIS- None declared. EDAT- 2024/09/24 04:21 MHDA- 2025/05/15 12:37 CRDT- 2024/09/23 19:32 PHST- 2025/05/15 12:37 [medline] PHST- 2024/09/24 04:21 [pubmed] PHST- 2024/09/23 19:32 [entrez] AID - 10.1055/a-2420-0202 [doi] PST - ppublish SO - Eur J Pediatr Surg. 2025 Jun;35(3):171-179. doi: 10.1055/a-2420-0202. Epub 2024 Sep 23. PMID- 39310997 OWN - NLM STAT- MEDLINE DCOM- 20240923 LR - 20260702 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 27 IP - 1 DP - 2024 Sep 23 TI - Measurement of food literacy among the adult population in urban Uganda and Kenya: development and validation of an East African food literacy scale. PG - e171 LID - 10.1017/S136898002400168X [doi] LID - e171 AB - OBJECTIVE: Food literacy (FL) is a potential approach to address the nutrition transition in Africa, but a validated tool is lacking. We developed and validated a scale to assess FL among Ugandan and Kenyan adult populations. DESIGN: A mixed-method approach was applied: (1) item development using literature, expert and target group insights, (2) independent country-specific validation (content, construct, criterion and concurrent) and (3) synchronisation of the two country-specific FL-scales. Construct validity was evaluated against the prime dietary quality score (PDQS) and healthy eating self-efficacy scale (HEWSE). SETTING: Urban Uganda and Kenya. PARTICIPANTS: Two cross-sectional cross-country surveys, adults >18 years (n = 214) and university students (n = 163), were conducted. RESULTS: The initial development yielded a forty-eight-item FL-scale draft. In total, twenty-six items were reframed to fit the country contexts. Six items differed content-wise across the two FL-scales and were dropped for a synchronised East African FL-scale. Weighted kappa tests revealed no deviations in individuals' FL when either the East African FL-scale or the country-specific FL-scales are used; 0.86 (95 % CI: 0.83, 0.89), Uganda and 0.86 (95 % CI: 0.84, 0.88), Kenya. The FL-scale showed good reliability (0.71 (95 % CI: 0.60, 0.79), Uganda; 0.78 (95 % CI: 0.69, 0.84), Kenya) and positively correlated with PDQS (r = 0.29 P = 0.003, Uganda; r = 0.26 P < 0.001, Kenya) and HEWSE (r = 0.32 P < 0.001, Uganda; r = 0.23, P = 0.017, Kenya). The FL-scale distinguishes populations with higher from those with lower FL (beta = 14.54 (95 % CI: 10.27, 18.81), Uganda; beta = 18.79 (95 % CI: 13.92, 23.68), Kenya). CONCLUSION: Provided culture-sensitive translation and adaptation are done, the scale may be used as a basis across East Africa. FAU - Yiga, Peter AU - Yiga P AD - Department of Food Technology, Kyambogo University, Kampala, Uganda. AD - Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium. AD - Mildmay Research Centre Uganda, Kampala, Uganda. FAU - Mokaya, Moses AU - Mokaya M AD - Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium. AD - Department of Human Nutrition Sciences, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya. FAU - Kiyimba, Tonny AU - Kiyimba T AD - Department of Food Technology, Kyambogo University, Kampala, Uganda. AD - Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium. FAU - Ogwok, Patrick AU - Ogwok P AD - Department of Food Technology, Kyambogo University, Kampala, Uganda. FAU - Kyallo, Florence AU - Kyallo F AD - Department of Human Nutrition Sciences, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya. FAU - Koole, Janna Lena AU - Koole JL AD - Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium. FAU - Boedt, Tessy AU - Boedt T AD - Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium. FAU - Matthys, Christophe AU - Matthys C AUID- ORCID: 0000-0003-1770-6862 AD - Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium. AD - Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20240923 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - Cross-Sectional Studies MH - *Diet, Healthy MH - East African People MH - *Health Literacy/statistics & numerical data MH - Kenya MH - Reproducibility of Results MH - Self Efficacy MH - Surveys and Questionnaires MH - Uganda MH - *Urban Population/statistics & numerical data PMC - PMC11505189 OTO - NOTNLM OT - Adult population OT - Development OT - Food literacy scale OT - Kenya OT - Uganda OT - Validation COIS- None to declare. EDAT- 2024/09/23 12:44 MHDA- 2024/09/23 12:45 PMCR- 2024/09/23 CRDT- 2024/09/23 06:23 PHST- 2024/09/23 12:45 [medline] PHST- 2024/09/23 12:44 [pubmed] PHST- 2024/09/23 06:23 [entrez] PHST- 2024/09/23 00:00 [pmc-release] AID - S136898002400168X [pii] AID - 10.1017/S136898002400168X [doi] PST - epublish SO - Public Health Nutr. 2024 Sep 23;27(1):e171. doi: 10.1017/S136898002400168X. PMID- 39310020 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240924 IS - 2277-9531 (Print) IS - 2319-6440 (Electronic) IS - 2277-9531 (Linking) VI - 13 DP - 2024 TI - Adherence to the Mediterranean diet and sleep quality are inter-correlated with flash glucose monitoring (FGM)-measured glycemia among children with type 1 diabetes. PG - 284 LID - 10.4103/jehp.jehp_1609_23 [doi] LID - 284 AB - BACKGROUND: We examined the inter-correlation between diet quality, objectively measured sleep duration, and subjectively measured sleep quality with flash glucose monitoring (FGM)-measured glycemia among young patients with type 1 diabetes (T1D). MATERIALS AND METHODS: Following cross-sectional design, Fitbit((R)) accelerometers were used to objectively assess sleep duration, while the validated questionnaires Pittsburgh sleep quality index and Mediterranean diet (MD) adherence were used to subjectively assess sleep quality and diet quality, respectively. Glycated hemoglobin (HbA1c) and FGM-reported glycemia components among children with T1D were assessed as well. RESULTS: Of the 47 participants surveyed (25 boys, 22 girls, 9.31 +/- 2.88 years), the majority reported high HbA1c, good sleep quality, and high adherence to the MD. However, only one-third of the participants reported a healthy sleep duration. Only the sleep latency was significantly (P < 0.05) associated with the time above range level 2 and time below range level 2 (P = 0.048) components of the FGM. A positive correlation (r = 0.309, P = 0.035) was reported between adherence to MD and time in range of the FGM. CONCLUSIONS: Diet quality and sleep quality are variably inter-correlated with FGM-measured glycemia among young patients with T1D and are suggested to be considered influential factors in FGM-monitored diabetes research on this age group. CI - Copyright: (c) 2024 Journal of Education and Health Promotion. FAU - Muayyad, Mariam AU - Muayyad M AD - Nutrition Department, Al Qassimi Women's and Children's Hospital, Sharjah, UAE. AD - Clinical Sciences Department, College of Medicine, University of Sharjah, Sharjah, UAE. FAU - Abusnana, Salah AU - Abusnana S AD - Clinical Sciences Department, College of Medicine, University of Sharjah, Sharjah, UAE. FAU - Mussa, Bashair M AU - Mussa BM AD - Basic Medical Sciences Department, College of Medicine, University of Sharjah, Sharjah, UAE. FAU - Helal, Radwa AU - Helal R AD - Burjeel Medical Centre, Abu Dhabi, UAE. FAU - Abdelrahim, Dana N AU - Abdelrahim DN AD - Research Institute for Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah, UAE. FAU - Abdelreheim, Naguib Hassan AU - Abdelreheim NH AD - Clinical Sciences Department, College of Medicine, University of Sharjah, Sharjah, UAE. FAU - Al Amiri, Elham AU - Al Amiri E AD - Diabetes and Endocrinology Department, Al Qassimi Women's and Children's Hospital, Sharjah, UAE. FAU - Daboul, Mays AU - Daboul M AD - Nutrition Department, Novomed Medical Centre, Dubai, UAE. FAU - Al-Abadla, Zainab AU - Al-Abadla Z AD - Diabetes and Endocrinology Department, Al Jalila Children's Specialty Hospital, Dubai, UAE. FAU - Lessan, Nader AU - Lessan N AD - Imperial College of London Diabetes Centre, Abu Dhabi, UAE. FAU - Faris, MoezAlIslam E AU - Faris ME AD - Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, UAE. AD - Healthy Aging, Longevity and Sustainability Research Group, Research Institute for Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah, UAE. AD - Nutrition and Food Research Group, Research Institute for Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah, UAE. LA - eng PT - Journal Article DEP - 20240729 PL - India TA - J Educ Health Promot JT - Journal of education and health promotion JID - 101593794 PMC - PMC11414882 OTO - NOTNLM OT - Diabetes mellitus OT - Mediterranean diet OT - glycemic control OT - healthy lifestyle OT - sleep quality COIS- There are no conflicts of interest. EDAT- 2024/09/23 07:29 MHDA- 2024/09/23 07:30 PMCR- 2024/07/29 CRDT- 2024/09/23 05:57 PHST- 2023/10/08 00:00 [received] PHST- 2023/12/13 00:00 [accepted] PHST- 2024/09/23 07:30 [medline] PHST- 2024/09/23 07:29 [pubmed] PHST- 2024/09/23 05:57 [entrez] PHST- 2024/07/29 00:00 [pmc-release] AID - JEHP-13-284 [pii] AID - 10.4103/jehp.jehp_1609_23 [doi] PST - epublish SO - J Educ Health Promot. 2024 Jul 29;13:284. doi: 10.4103/jehp.jehp_1609_23. eCollection 2024. PMID- 39309139 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240924 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 11 DP - 2024 TI - Ultra-processed foods intake and sex hormone levels among children and adolescents aged 6-19 years: a cross-sectional study. PG - 1451481 LID - 10.3389/fnut.2024.1451481 [doi] LID - 1451481 AB - BACKGROUND: Sex hormones are crucial for the development of children and adolescents. The increasing consumption of ultra-processed foods (UPFs) among children and adolescents in the United States (US) has raised concerns about their potential impact on health, including hormonal balance. METHODS: Data from 3,354 participants aged 6-19 years from the NHANES 2013-2016 were analyzed. UPF intake was categorized using the NOVA food classification system, and the percentage of total daily energy intake from UPFs was calculated. The serum levels of total testosterone (TT), sex hormone-binding globulin (SHBG), and estradiol (E2) were measured. The free androgen index (FAI) and TT/E2 ratio were calculated to estimate bioavailable testosterone levels and the balance between androgens and estrogens, respectively. Multiple linear regression models, adjusted for potential confounders, estimated the associations. RESULTS: Our results showed that higher intake of UPFs was marginally associated with decreased serum SHBG levels (quartile (Q) 2 vs. Q1: beta = -5.3, 95% confidence interval (CI): -17.0, 8.1%; Q3 vs. Q1: beta = -14.6, 95%CI: -25.1, -2.5%; Q4 vs. Q1: beta = -9.0, 95%CI: -20.3, 3.8%; P trend = 0.081), and significantly associated with increased serum FAI in female adolescents (Q2 vs. Q1: beta = 3.2, 95%CI: -3.3, 9.7; Q3 vs. Q1: beta = 7.6, 95%CI: -0.7, 16.0; Q4 vs. Q1: beta = 9.5, 95%CI: 1.5, 17.6; P trend = 0.019). Additionally, UPF intake showed a marginally positive association with increased serum SHBG levels (P trend = 0.057) in male children and FAI (P trend = 0.150) in male adolescents, respectively. Similar results were observed when participants were stratified by puberty status, except for the association between UPF intake and SHBG in male children. However, there were no associations between UPF consumption and TT, E2, or the TT/E2 ratio, both in males and females. CONCLUSION: Higher UPF consumption is associated with increased FAI in adolescents, particularly in girls, indicating higher bioavailable testosterone levels. Future studies should validate these findings with direct free testosterone measurements and more precise dietary intake assessments. CI - Copyright (c) 2024 Zhao, Gui, Liu, Zhao, Fan, Jing and Sun. FAU - Zhao, Hao AU - Zhao H AD - Department of Preventive Medicine, School of Basic Medical Sciences, Jiujiang University, Jiujiang, China. AD - Jiangxi Provincial Key Laboratory of Cell Precision Therapy, School of Basic Medical Sciences, Jiujiang University, Jiujiang, China. FAU - Gui, Wei AU - Gui W AD - Department of Pediatric, The Affiliated Hospital of Jiujiang University, Jiujiang, China. FAU - Liu, Shangtao AU - Liu S AD - Department of Preventive Medicine, School of Basic Medical Sciences, Jiujiang University, Jiujiang, China. FAU - Zhao, Fangyu AU - Zhao F AD - Department of Preventive Medicine, School of Basic Medical Sciences, Jiujiang University, Jiujiang, China. FAU - Fan, Wenyan AU - Fan W AD - Department of Preventive Medicine, School of Basic Medical Sciences, Jiujiang University, Jiujiang, China. FAU - Jing, Fangyuan AU - Jing F AD - Department of Molecular Mechanisms of Chronic Diseases, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China. FAU - Sun, Chuan AU - Sun C AD - Zhejiang Key Laboratory of Geriatrics and Geriatrics Institute of Zhejiang Province, Zhejiang Hospital, Hangzhou, China. LA - eng PT - Journal Article DEP - 20240906 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC11412839 OTO - NOTNLM OT - adolescent OT - child OT - cross-sectional OT - sex hormones OT - ultra-processed foods COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/09/23 07:30 MHDA- 2024/09/23 07:31 PMCR- 2024/01/01 CRDT- 2024/09/23 05:44 PHST- 2024/06/19 00:00 [received] PHST- 2024/08/21 00:00 [accepted] PHST- 2024/09/23 07:31 [medline] PHST- 2024/09/23 07:30 [pubmed] PHST- 2024/09/23 05:44 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - 10.3389/fnut.2024.1451481 [doi] PST - epublish SO - Front Nutr. 2024 Sep 6;11:1451481. doi: 10.3389/fnut.2024.1451481. eCollection 2024. PMID- 39308771 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240924 IS - 2399-3529 (Electronic) IS - 2399-3529 (Linking) VI - 2024 IP - 3 DP - 2024 TI - Correlation of anogenital distance from childhood to age 9 years-a prospective population-based birth cohort-the Odense Child Cohort. PG - hoae050 LID - 10.1093/hropen/hoae050 [doi] LID - hoae050 AB - STUDY QUESTION: Does anogenital distance (AGD) - distance from the anus to the genitals - correlate from infancy (3 months) to the age of 9 years in boys and girls? SUMMARY ANSWER: In boys, AGD correlated from infancy to 9 years of age, whereas in girls, correlations were weaker, especially between infancy and later childhood. WHAT IS KNOWN ALREADY: AGD is considered a marker for prenatal androgen action. In males, reduced AGD is associated with testicular cancer, infertility, and lower sperm count. In females, AGD is associated with endometriosis and polycystic ovary syndrome. STUDY DESIGN SIZE DURATION: In the Odense Child Cohort, a prospective population-based birth cohort, pregnant women were enrolled in early pregnancy. AGD and BMI were measured repeatedly in children at ages 3 and 18 months, as well as at 3, 5, 7, and 9 years. PARTICIPANTS/MATERIALS SETTING METHODS: AGD was measured from the anus to the scrotum (AGDas) and to the penis (AGDap) in 1022 boys, and to the posterior fourchette and the clitoris in 887 girls repeatedly between the age of 3 months to 9 years. In total, 7706 assessments were made. AGD was adjusted for body weight, and SD scores (the difference between individual AGD and the mean of AGD in the population divided by SD of AGD) were calculated for each child. Pearson correlation coefficient (r) of each measurement was performed to investigate whether individual AGD was stable during childhood. Short predictive values at 3 months (20th percentile) to 9 years were investigated using the AUC produced by the receiver operating characteristic curve. MAIN RESULTS AND THE ROLE OF CHANCE: In boys, AGD/body size-index SD score correlated significantly between infancy and 9 years, strongest for AGDas (r = 0.540 P > 0.001). In girls, weaker significant correlation coefficients were found between AGD at infancy and 9 years; higher correlation coefficients were found between AGD from 3 to 9 years (P > 0.001). Short AGDas in infancy predicted short AGDas in boys aged 9 years (AUC: 0.767, sensitivity 0.71, specificity 0.71). The predictive values of short infant AGDap, penile width (in boys), and AGD (in girls) concerning short outcomes at 9 years were low. LIMITATIONS REASONS FOR CAUTION: The AGD measurements are less precisely measurable in girls compared to boys, especially in infancy, resulting in less reproducible measurements. Additionally, because AGD is shorter in girls, the same absolute measurement error is relatively more significant, potentially contributing to greater variability and lower reproducibility in girls. This may contribute to the weaker correlations in girls compared to boys. WIDER IMPLICATIONS OF THE FINDINGS: In boys, AGDas, relative to body size, correlated from infancy to 9 years, suggesting that AGD in infancy can be considered a non-invasive marker of later reproductive health. Further follow-up studies are needed to evaluate long-term individual tracking of AGD as well as assessment of childhood AGD as early marker of adult reproductive health. STUDY FUNDING/COMPETING INTERESTS: This study was supported by Odense University Hospital, Denmark, the Region of Southern Denmark, the Municipality of Odense, Denmark, the University of Southern Denmark, Odense Patient data Exploratory Network (OPEN), Denmark, the Danish Research Council (4004-00352B_FSS), Novo Nordisk Foundation, Denmark (grant no. NNF19OC0058266 and NNF17OC0029404), Sygeforsikring Danmark (journalnr. 2021-0173), the Collaborative Foundation between Odense University Hospital and Rigshospitalet, and Helsefonden. There is no conflict of interest of any author that could be perceived as prejudicing the impartiality of the research reported. TRIAL REGISTRATION NUMBER: N/A. CI - (c) The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. FAU - Andreasen, Sarah Munk AU - Andreasen SM AUID- ORCID: 0000-0001-6323-2421 AD - Department of Clinical Pharmacology, Pharmacy and Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark. AD - Hans Christian Andersen Research, Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark. FAU - Gehrt, Lise AU - Gehrt L AD - Department of Clinical Pharmacology, Pharmacy and Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark. AD - Hans Christian Andersen Research, Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark. FAU - Hagen, Casper P AU - Hagen CP AUID- ORCID: 0000-0002-0250-8049 AD - Department of Growth and Reproduction, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark. AD - International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen, Denmark. FAU - Juul, Anders AU - Juul A AUID- ORCID: 0000-0002-0534-4350 AD - Department of Growth and Reproduction, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark. AD - International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. FAU - Mola, Gylli AU - Mola G AUID- ORCID: 0000-0002-9853-999X AD - Department of Growth and Reproduction, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark. AD - International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen, Denmark. FAU - Fischer, Margit Bistrup AU - Fischer MB AUID- ORCID: 0000-0002-7999-548X AD - Department of Growth and Reproduction, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark. AD - International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen, Denmark. FAU - Andersen, Marianne Skovsager AU - Andersen MS AUID- ORCID: 0000-0002-4603-9504 AD - Department of Endocrinology, Odense University Hospital, Odense, Denmark. AD - Department of Clinical Research, Institute of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. FAU - Kristensen, David Mobjerg AU - Kristensen DM AUID- ORCID: 0000-0002-3691-7289 AD - Department of Growth and Reproduction, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark. AD - Department of Science and Environment, Roskilde University, Roskilde, Denmark. FAU - Jensen, Tina Kold AU - Jensen TK AUID- ORCID: 0000-0003-2311-5778 AD - Department of Clinical Pharmacology, Pharmacy and Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark. AD - Hans Christian Andersen Research, Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark. AD - Odense Patient Data Explorative Network, Odense University Hospital, Odense, Denmark. LA - eng PT - Journal Article DEP - 20240909 PL - England TA - Hum Reprod Open JT - Human reproduction open JID - 101722764 PMC - PMC11415829 OTO - NOTNLM OT - anogenital distance OT - childhood OT - cohort study OT - endocrine disruption OT - reproductive health COIS- The authors declare that they have no conflicts of interest. EDAT- 2024/09/23 07:29 MHDA- 2024/09/23 07:30 PMCR- 2024/09/09 CRDT- 2024/09/23 05:38 PHST- 2024/04/02 00:00 [received] PHST- 2024/08/07 00:00 [revised] PHST- 2024/09/23 07:30 [medline] PHST- 2024/09/23 07:29 [pubmed] PHST- 2024/09/23 05:38 [entrez] PHST- 2024/09/09 00:00 [pmc-release] AID - hoae050 [pii] AID - 10.1093/hropen/hoae050 [doi] PST - epublish SO - Hum Reprod Open. 2024 Sep 9;2024(3):hoae050. doi: 10.1093/hropen/hoae050. eCollection 2024. PMID- 39308209 OWN - NLM STAT- MEDLINE DCOM- 20241031 LR - 20260819 IS - 1475-2662 (Electronic) IS - 0007-1145 (Linking) VI - 132 IP - 5 DP - 2024 Sep 14 TI - Meat intake and type 2 diabetes among Japanese workers: a prospective study. PG - 624-630 LID - 10.1017/S0007114524001922 [doi] AB - Red meat and processed meat intake has been linked to increased risk of type 2 diabetes; however, evidence from Asia is limited and inconsistent. We prospectively examined the association of intake of total meat and its subtype with type 2 diabetes in a Japanese working population. Participants were 2709 workers aged 18-78 years who reported no history of diabetes when they responded to a health survey for the first time between 2012 and 2019. Dietary intake was assessed using a validated self-administered diet history questionnaire. The incidence of type 2 diabetes was assessed via annual health checkups from baseline through March 2023. Type 2 diabetes was defined as fasting blood glucose >/= 126 mg/dl, casual blood glucose >/= 200 mg/dl, HbA1c >/= 6.5 %, self-report of diabetes or current use of anti-diabetic drugs. Hazard ratios according to tertile of meat intake were estimated using Cox proportional hazards regression. During 16 119 person-years of follow-up, 135 (5.0 %) workers developed type 2 diabetes. Intakes of total meat, red meat, processed meat and poultry were not associated with risk of type 2 diabetes. After adjustment for covariates, hazard ratios for the highest v. lowest tertile of meat intake were 1.01 (95 % CI 0.63, 1.62) for total meat, 1.02 (95 % CI 0.66, 1.58) for red meat, 0.99 (95 % CI 0.65, 1.49) for processed meat and 1.13 (95 % CI 0.71, 1.80) for poultry. Our findings suggest that meat intake is not associated with the risk of type 2 diabetes among Japanese workers. FAU - Nanri, Akiko AU - Nanri A AUID- ORCID: 0000-0002-7487-8778 AD - Graduate School of Health and Environmental Sciences, Fukuoka Women's University, Fukuoka, Japan. AD - Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan. FAU - Irie, Sakiho AU - Irie S AD - Graduate School of Health and Environmental Sciences, Fukuoka Women's University, Fukuoka, Japan. FAU - Kochi, Takeshi AU - Kochi T AD - Department of Health Administration, Furukawa Electric Corporation, Tokyo, Japan. FAU - Kabe, Isamu AU - Kabe I AD - Kubota Corporation, Tsukubamirai, Japan. FAU - Konishi, Maki AU - Konishi M AD - Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan. FAU - Mizoue, Tetsuya AU - Mizoue T AD - Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240923 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/etiology/epidemiology MH - Middle Aged MH - Adult MH - Japan/epidemiology MH - Male MH - Female MH - Prospective Studies MH - Aged MH - *Meat MH - Young Adult MH - *Diet/adverse effects MH - Adolescent MH - Risk Factors MH - Red Meat/adverse effects MH - Incidence MH - Proportional Hazards Models MH - East Asian People OTO - NOTNLM OT - Japanese OT - Meat intake OT - Prospective study OT - Type 2 diabetes EDAT- 2024/09/23 07:29 MHDA- 2024/10/31 18:21 CRDT- 2024/09/23 03:43 PHST- 2024/10/31 18:21 [medline] PHST- 2024/09/23 07:29 [pubmed] PHST- 2024/09/23 03:43 [entrez] AID - S0007114524001922 [pii] AID - 10.1017/S0007114524001922 [doi] PST - ppublish SO - Br J Nutr. 2024 Sep 14;132(5):624-630. doi: 10.1017/S0007114524001922. Epub 2024 Sep 23. PMID- 39306542 OWN - NLM STAT- MEDLINE DCOM- 20241122 LR - 20241221 IS - 1878-0210 (Electronic) IS - 1878-0210 (Linking) VI - 18 IP - 6 DP - 2024 Dec TI - Impact of the culturally adapted kids in control of food (KICk OFF) educational program on glycemic control and BMI in adolescents with type 1 diabetes in Kuwait: A retrospective study. PG - 632-636 LID - S1751-9918(24)00191-8 [pii] LID - 10.1016/j.pcd.2024.09.002 [doi] AB - AIMS: To examine the effectiveness of the culturally adapted Kids in Control Of Food (KICk OFF) structured educational program on glycemic control and BMI z-scores (BMIz) in adolescents with type 1 diabetes in Kuwait. METHODS: We conducted a retrospective analysis of 161 adolescents aged 11-16 years with type 1 diabetes who participated in the culturally adapted KICk OFF program at Dasman Diabetes Institute from 2019 to 2023. Changes in glycated hemoglobin (HbA1c) and BMIz were assessed from baseline to six months post-program using paired t-tests and Wilcoxon signed-rank tests, respectively. RESULTS: After six months post-program, there was a significant reduction in HbA1c levels (mean +/- standard deviation) from 9.3 +/- 1.8 % (78 +/- 20 mmol/mol) to 8.9 +/- 1.7 % (74 +/- 19 mmol/mol), P <0.0001. The greatest improvements observed in participants with baseline HbA1c >9.5 % (reduction of 0.70 % [8 mmol/mol]) and those with HbA1c 7.5-9.5 % (reduction of 0.32 % [4 mmol/mol]). There was a slight increase in median BMIz by 0.08 (interquartile range -0.04-0.22). CONCLUSIONS: The culturally adapted KICk OFF program shows a potential in improving glycemic control among adolescents with type 1 diabetes, particularly in those with initially suboptimal control. Future research through randomized controlled trials and over longer periods is recommended to validate these results. CI - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Al-Lahou, Badreya A AU - Al-Lahou BA AD - Dasman Diabetes Institute, Kuwait City, Kuwait. Electronic address: badreyaallahou@gmail.com. FAU - AlMatrook, Reem Y AU - AlMatrook RY AD - Dasman Diabetes Institute, Kuwait City, Kuwait. FAU - AlSarraf, Ali H AU - AlSarraf AH AD - Dasman Diabetes Institute, Kuwait City, Kuwait. FAU - AlShammari, Asmaa A AU - AlShammari AA AD - Dasman Diabetes Institute, Kuwait City, Kuwait. FAU - AlSumaiti, Durra K AU - AlSumaiti DK AD - Dasman Diabetes Institute, Kuwait City, Kuwait. FAU - Al-Mahdi, Maria J AU - Al-Mahdi MJ AD - Dasman Diabetes Institute, Kuwait City, Kuwait. FAU - Alozairi, Ebaa A AU - Alozairi EA AD - Dasman Diabetes Institute, Kuwait City, Kuwait. LA - eng PT - Journal Article DEP - 20240920 PL - England TA - Prim Care Diabetes JT - Primary care diabetes JID - 101463825 RN - 0 (Glycated Hemoglobin) RN - 0 (hemoglobin A1c protein, human) RN - 0 (Blood Glucose) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Adolescent MH - *Diabetes Mellitus, Type 1/blood/diagnosis/therapy MH - Kuwait/epidemiology MH - Retrospective Studies MH - Male MH - Female MH - Child MH - *Glycated Hemoglobin/metabolism MH - *Glycemic Control MH - *Patient Education as Topic MH - *Blood Glucose/metabolism MH - *Body Mass Index MH - Treatment Outcome MH - Health Knowledge, Attitudes, Practice MH - Biomarkers/blood MH - Time Factors MH - Program Evaluation MH - Cultural Characteristics MH - Age Factors MH - Culturally Competent Care/ethnology MH - Adolescent Behavior MH - Pediatric Obesity/diagnosis/therapy/blood/ethnology MH - Diet, Healthy OTO - NOTNLM OT - Adolescents OT - Arab countries OT - Educational program OT - HbA1c OT - Kuwait OT - Type 1 diabetes COIS- Declaration of Competing Interest No potential conflicts of interest relevant to this article were reported. EDAT- 2024/09/22 00:42 MHDA- 2024/11/23 11:14 CRDT- 2024/09/21 21:59 PHST- 2024/06/13 00:00 [received] PHST- 2024/09/01 00:00 [revised] PHST- 2024/09/12 00:00 [accepted] PHST- 2024/11/23 11:14 [medline] PHST- 2024/09/22 00:42 [pubmed] PHST- 2024/09/21 21:59 [entrez] AID - S1751-9918(24)00191-8 [pii] AID - 10.1016/j.pcd.2024.09.002 [doi] PST - ppublish SO - Prim Care Diabetes. 2024 Dec;18(6):632-636. doi: 10.1016/j.pcd.2024.09.002. Epub 2024 Sep 20. PMID- 39306042 OWN - NLM STAT- MEDLINE DCOM- 20241105 LR - 20260529 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 203 DP - 2024 Dec 1 TI - Eating disorder risk among Australian youth starting a diet in the community. PG - 107685 LID - S0195-6663(24)00488-4 [pii] LID - 10.1016/j.appet.2024.107685 [doi] AB - Dieting is a potent risk factor for eating disorder (ED) symptoms and development, which typically occur in late adolescence. However, as diets are often motivated by body image concerns (another core ED risk factor), dieters may already carry heightened ED risk. Thus, the current study aimed to document ED risk among young people starting a diet in the community. Young people (16-25 years) starting or intending to start a self-initiated diet (N = 727) provided data via a screener questionnaire, assessing containing sociodemographic factors, past and current ED symptoms and behaviours. Over a third (36.9%) screened using a validated instrument were found to be at-risk of a current ED, with 10% above the clinical cut-off. Consistent with this finding, over 10% of the sample self-reported experiencing a lifetime ED, while nearly a quarter reported symptoms consistent with an ED diagnosis with no reported formal diagnosis. Findings suggest a high level of ED risk among young people starting a diet in the community and point to the need for more proactive measures targeted at this cohort (e.g., screening, monitoring). Further education on the risks of dieting and encouragement for help-seeking in young people is indicated. CI - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Pehlivan, Melissa J AU - Pehlivan MJ AD - InsideOut Institute for Eating Disorders, The University of Sydney & Sydney Local Health District, NSW, 2006, Australia. FAU - Okada, Mirei AU - Okada M AD - The Charles Perkins Centre and School of Life and Environmental Sciences, University of Sydney, NSW, 2006, Australia. FAU - Miskovic-Wheatley, Jane AU - Miskovic-Wheatley J AD - InsideOut Institute for Eating Disorders, The University of Sydney & Sydney Local Health District, NSW, 2006, Australia. FAU - Barakat, Sarah AU - Barakat S AD - InsideOut Institute for Eating Disorders, The University of Sydney & Sydney Local Health District, NSW, 2006, Australia. FAU - Touyz, Stephen AU - Touyz S AD - InsideOut Institute for Eating Disorders, The University of Sydney & Sydney Local Health District, NSW, 2006, Australia. FAU - Simpson, Stephen J AU - Simpson SJ AD - The Charles Perkins Centre and School of Life and Environmental Sciences, University of Sydney, NSW, 2006, Australia. FAU - Griffiths, Kristi AU - Griffiths K AD - InsideOut Institute for Eating Disorders, The University of Sydney & Sydney Local Health District, NSW, 2006, Australia. FAU - Holmes, Andrew AU - Holmes A AD - The Charles Perkins Centre and School of Life and Environmental Sciences, University of Sydney, NSW, 2006, Australia. FAU - Maguire, Sarah AU - Maguire S AD - InsideOut Institute for Eating Disorders, The University of Sydney & Sydney Local Health District, NSW, 2006, Australia. Electronic address: sarah.maguire@sydney.edu.au. LA - eng PT - Journal Article DEP - 20240919 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - *Feeding and Eating Disorders/epidemiology/psychology MH - Young Adult MH - Risk Factors MH - Australia MH - Surveys and Questionnaires MH - Adult MH - Body Image/psychology MH - Diet MH - Diet, Reducing/psychology MH - Feeding Behavior/psychology COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/09/22 04:20 MHDA- 2024/11/06 00:22 CRDT- 2024/09/21 19:26 PHST- 2024/04/29 00:00 [received] PHST- 2024/09/13 00:00 [revised] PHST- 2024/09/17 00:00 [accepted] PHST- 2024/11/06 00:22 [medline] PHST- 2024/09/22 04:20 [pubmed] PHST- 2024/09/21 19:26 [entrez] AID - S0195-6663(24)00488-4 [pii] AID - 10.1016/j.appet.2024.107685 [doi] PST - ppublish SO - Appetite. 2024 Dec 1;203:107685. doi: 10.1016/j.appet.2024.107685. Epub 2024 Sep 19. PMID- 39305753 OWN - NLM STAT- MEDLINE DCOM- 20240929 LR - 20260812 IS - 1532-1983 (Electronic) IS - 0261-5614 (Print) IS - 0261-5614 (Linking) VI - 43 IP - 10 DP - 2024 Oct TI - Trunk-to-leg volume and appendicular lean mass from a commercial 3-dimensional optical body scanner for disease risk identification. PG - 2430-2437 LID - S0261-5614(24)00339-X [pii] LID - 10.1016/j.clnu.2024.09.028 [doi] AB - BACKGROUND & AIMS: Body shape expressed as the trunk-to-leg volume ratio is associated with diabetes and mortality due to the associations between higher adiposity and lower lean mass with Metabolic Syndrome (MetS) risk. Reduced appendicular muscle mass is associated with malnutrition risk and age-related frailty, and is a risk factor for poor treatment outcomes related to MetS and other clinical conditions (e.g.; cancer). These measures are traditionally assessed by dual-energy X-ray absorptiometry (DXA), which can be difficult to access in clinical settings. The Shape Up! Adults trial (SUA) demonstrated the accuracy and precision of 3-dimensional optical imaging (3DO) for body composition as compared to DXA and other criterion measures. Here we assessed whether trunk-to-leg volume estimates derived from 3DO are associated with MetS risk in a similar way as when measured by DXA. We further explored if estimations of appendicular lean mass (ALM) could be made using 3DO to further improve the accessibility of measuring this important frailty and disease risk factor. METHODS: SUA recruited participants across sex, age (18-40, 40-60, >60 years), BMI (under, normal, overweight, obese), and race/ethnicity (non-Hispanic [NH] Black, NH White, Hispanic, Asian, Native Hawaiian/Pacific Islander) categories. Each participant had whole-body DXA and 3DO scans, and measures of cardiovascular health. The 3DO measures of trunk and leg volumes were calibrated to DXA to express equivalent trunk-to-leg volume ratios. We expressed each blood measure and overall MetS risk in quartile gradations of trunk-to-leg volume previously defined by National Health and Nutrition Examination Survey (NHANES). Finally, we utilized 3DO measures to estimate DXA ALM using ten-fold cross-validation of the entire dataset. RESULTS: Participants were 502 (273 female) adults, mean age = 46.0 +/- 16.5y, BMI = 27.6 +/- 7.1 kg/m(2) and a mean DXA trunk-to-leg volume ratio of 1.47 +/- 0.22 (females: 1.43 +/- 0.23; males: 1.52 +/- 0.20). After adjustments for age and sex, each standard deviation increase in trunk-to-leg volume by 3DO was associated with a 3.3 (95% odds ratio [OR] = 2.4-4.2) times greater risk of MetS, with individuals in the highest quartile of trunk-to-leg at 27.4 (95% CI: 9.0-53.1) times greater risk of MetS compared to the lowest quartile. Risks of elevated blood biomarkers as related to high 3DO trunk-to-leg volume ratios were similar to previously published comparisons using DXA trunk-to-leg volume ratios. Estimated ALM by 3DO was correlated to DXA (r(2) = 0.96, root mean square error = 1.5 kg) using ten-fold cross-validation. CONCLUSION: Using thresholds of trunk-to-leg associated with MetS developed on a sample of US-representative adults, trunk-to-leg ratio by 3DO after adjustments for offsets showed significant associations to blood parameters and MetS risk. 3DO scans provide a precise and accurate estimation of ALM across the range of body sizes included in the study sample. The development of these additional measures improves the clinical utility of 3DO for the assessment of MetS risk as well as the identification of low muscle mass associated with poor cardiometabolic and functional health. CI - Published by Elsevier Ltd. FAU - Bennett, Jonathan P AU - Bennett JP AD - Department of Epidemiology, University of Hawai'i Cancer Center, 701 Ilalo St, Honolulu, HI, 96813, USA. Electronic address: jbennett@cc.hawaii.edu. FAU - Wong, Michael C AU - Wong MC AD - Department of Epidemiology, University of Hawai'i Cancer Center, 701 Ilalo St, Honolulu, HI, 96813, USA. FAU - Liu, Yong En AU - Liu YE AD - Department of Epidemiology, University of Hawai'i Cancer Center, 701 Ilalo St, Honolulu, HI, 96813, USA. FAU - Quon, Brandon K AU - Quon BK AD - Department of Epidemiology, University of Hawai'i Cancer Center, 701 Ilalo St, Honolulu, HI, 96813, USA. FAU - Kelly, Nisa N AU - Kelly NN AD - Department of Epidemiology, University of Hawai'i Cancer Center, 701 Ilalo St, Honolulu, HI, 96813, USA. FAU - Garber, Andrea K AU - Garber AK AD - Division of Adolescent & Young Adult Medicine, University of California, San Francisco, 3333 California Street, Suite 245, San Francisco, CA, 94118, USA. FAU - Heymsfield, Steven B AU - Heymsfield SB AD - Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA, 70808, USA. FAU - Shepherd, John A AU - Shepherd JA AD - Department of Epidemiology, University of Hawai'i Cancer Center, 701 Ilalo St, Honolulu, HI, 96813, USA. LA - eng SI - ClinicalTrials.gov/NCT03637855 GR - P30 CA071789/CA/NCI NIH HHS/United States GR - P30 DK072476/DK/NIDDK NIH HHS/United States GR - R01 DK109008/DK/NIDDK NIH HHS/United States GR - T32 HL115505/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20240916 PL - England TA - Clin Nutr JT - Clinical nutrition (Edinburgh, Scotland) JID - 8309603 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Middle Aged MH - *Body Composition MH - *Absorptiometry, Photon/methods MH - Young Adult MH - *Leg MH - Metabolic Syndrome MH - Imaging, Three-Dimensional/methods MH - Adolescent MH - Risk Factors MH - Torso/diagnostic imaging MH - Risk Assessment MH - Aged MH - Optical Imaging/methods MH - Body Mass Index PMC - PMC11439580 MID - NIHMS2024385 OTO - NOTNLM OT - 3-dimensional optical OT - Appendicular lean mass OT - Body composition OT - Metabolic syndrome OT - Trunk-to-leg volume COIS- Conflict of interest None. EDAT- 2024/09/22 04:20 MHDA- 2024/09/30 04:18 PMCR- 2025/10/01 CRDT- 2024/09/21 18:08 PHST- 2024/07/03 00:00 [received] PHST- 2024/08/24 00:00 [revised] PHST- 2024/09/12 00:00 [accepted] PHST- 2024/09/30 04:18 [medline] PHST- 2024/09/22 04:20 [pubmed] PHST- 2024/09/21 18:08 [entrez] PHST- 2025/10/01 00:00 [pmc-release] AID - S0261-5614(24)00339-X [pii] AID - 10.1016/j.clnu.2024.09.028 [doi] PST - ppublish SO - Clin Nutr. 2024 Oct;43(10):2430-2437. doi: 10.1016/j.clnu.2024.09.028. Epub 2024 Sep 16. PMID- 39305651 OWN - NLM STAT- MEDLINE DCOM- 20241110 LR - 20241110 IS - 1873-6297 (Electronic) IS - 0001-6918 (Linking) VI - 250 DP - 2024 Oct TI - The Association Study on Physical Activity Intensity, Sleep Quality, and Depression among College Students in the Central Plains Region. PG - 104497 LID - S0001-6918(24)00375-5 [pii] LID - 10.1016/j.actpsy.2024.104497 [doi] AB - This investigation sought to understand how physical activity, sleep quality, and depression interrelate among university students in a particular region of China. It involved a diverse group of 2363 students from three institutions, using a cross-sectional approach with well-established measurement tools. These tools demonstrated strong reliability and validity, with Cronbach's alpha values indicating robust internal consistency. The data revealed that higher levels of physical activity were inversely related to depression and directly related to better sleep quality, highlighting the potential of exercise and sleep improvement to reduce depressive symptoms among this demographic. CI - Copyright (c) 2024 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Ma, Ding AU - Ma D AD - College of Physical Education, Zhengzhou University of Light Industry, Zhengzhou 450000, China; Gdansk University of Physical Education and Sport, Gdansk 80-336, Poland. Electronic address: allahmartin@163.com. FAU - Fang, Hui AU - Fang H AD - College of Physical Education, Zhengzhou University of Light Industry, Zhengzhou 450000, China. FAU - Li, Yang AU - Li Y AD - College of Physical Education, Zhengzhou University of Light Industry, Zhengzhou 450000, China. FAU - Sun, Yifang AU - Sun Y AD - College of Physical Education, Zhengzhou University of Light Industry, Zhengzhou 450000, China. FAU - Wang, Suifang AU - Wang S AD - College of Physical Education, Zhengzhou University of Light Industry, Zhengzhou 450000, China. LA - eng PT - Journal Article DEP - 20240920 PL - Netherlands TA - Acta Psychol (Amst) JT - Acta psychologica JID - 0370366 SB - IM MH - Humans MH - *Students/psychology MH - Male MH - Female MH - *Exercise MH - *Sleep Quality MH - *Depression MH - Young Adult MH - Universities MH - Cross-Sectional Studies MH - China/epidemiology MH - Adult MH - Adolescent MH - Surveys and Questionnaires OTO - NOTNLM OT - Depression OT - Physical activity OT - Sleep quality COIS- Declaration of competing interest The authors declared that this article is no conflict of interest. EDAT- 2024/09/22 04:20 MHDA- 2024/11/13 13:49 CRDT- 2024/09/21 18:05 PHST- 2024/04/15 00:00 [received] PHST- 2024/09/11 00:00 [revised] PHST- 2024/09/12 00:00 [accepted] PHST- 2024/11/13 13:49 [medline] PHST- 2024/09/22 04:20 [pubmed] PHST- 2024/09/21 18:05 [entrez] AID - S0001-6918(24)00375-5 [pii] AID - 10.1016/j.actpsy.2024.104497 [doi] PST - ppublish SO - Acta Psychol (Amst). 2024 Oct;250:104497. doi: 10.1016/j.actpsy.2024.104497. Epub 2024 Sep 20. PMID- 39304916 OWN - NLM STAT- MEDLINE DCOM- 20240921 LR - 20260521 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 23 IP - 1 DP - 2024 Sep 20 TI - Dietary pattern trajectories in early childhood and their associations with patterns of maternal feeding practices in a multi-ethnic Asian cohort. PG - 110 LID - 10.1186/s12937-024-01012-5 [doi] LID - 110 AB - BACKGROUND: Maternal feeding practices play a major role in children's dietary intakes. However, there is limited data on the associations between trajectories of dietary patterns (DPs) and patterns of maternal feeding practices during early childhood. METHODS: Using data from a multi-ethnic Asian cohort study, namely the Growing Up in Singapore Towards healthy Outcomes (GUSTO), dietary intakes were measured using Food Frequency Questionnaires in children at 18 months, 5 and 7 years of age. Maternal feeding practices were assessed using validated questionnaires at 15 months, 3 and 5 years of age. Principal component analysis was used to derive 2 major DPs at all time-points as well as patterns of maternal feeding practices. Group-based trajectory modelling was used to identify trajectory groups for the derived DPs. Multivariable logistic regression examined associations between patterns of maternal feeding practices and DP trajectory groups. RESULTS: Two DPs, namely the 'healthy' and 'less healthy' were consistently derived at 18 months, 5 and 7 years of age. From each DP, 2 stable DP trajectory groups were further identified between 18 months and 7 years of age. For the 'healthy' DP trajectory, majority of the children (Group 1) formed a consistent average adherence trajectory group (91.8%) while the remaining children (Group 2) showed a higher but decreasing adherence (8.2%) to this DP. For the 'less healthy' DP trajectory, most children (Group 1) formed a consistent average adherence trajectory (95.5%), while the remainder (Group 2) showed consistent higher adherence to this 'less healthy' DP (4.5%). Two patterns of maternal feeding practices were derived and labelled as 'structured with autonomy support' and 'coercive control', respectively, at ages 15 months, 3 and 5 years. Children whose mothers showed high adherence to the structured with autonomy support feeding practices at age 5 years were significantly more likely to be associated with the higher but decreasing 'healthy' DP trajectory group [OR = 3.62 (95% CI: 1.64, 7.99)]. CONCLUSIONS: A small number of children in this multi-ethnic study showed high adherence to the 'healthy' or 'less healthy' DP trajectory groups, respectively, while the majority showed average adherence to either of these trajectories. The positive association between structured with autonomy support maternal feeding practices and higher z-scores for the healthy DP trajectory highlights the importance of guiding parents on appropriate feeding practices. CI - (c) 2024. The Author(s). FAU - Appannah, Geeta AU - Appannah G AD - Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia. AD - Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. FAU - Toh, Jia Ying AU - Toh JY AD - Institute for Human Development and Potential, Agency for Science, Technology, and Research, Singapore, Singapore. FAU - Lai, Jun Shi AU - Lai JS AD - Institute for Human Development and Potential, Agency for Science, Technology, and Research, Singapore, Singapore. FAU - Yong, Heng Yaw AU - Yong HY AD - Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia. AD - Division of Nutrition and Dietetics, School of Health Sciences, IMU University, Kuala Lumpur, Malaysia. FAU - Shariff, Zalilah Mohd AU - Shariff ZM AD - Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia. FAU - Tint, Mya Thway AU - Tint MT AD - Institute for Human Development and Potential, Agency for Science, Technology, and Research, Singapore, Singapore. AD - Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. FAU - Yuan, Wen Lun AU - Yuan WL AD - Universite Paris Cite, CRESS, Inserm, INRAE, Paris, F-75004, France. FAU - Pang, Wei Wei AU - Pang WW AD - Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. FAU - Godfrey, Keith M AU - Godfrey KM AD - Medical Research Council Lifecourse Epidemiology Centre, National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital, Southampton National Health Service Foundation Trust, Southampton, UK. FAU - Tan, Kok Hian AU - Tan KH AD - Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore, Singapore. AD - Duke-NUS Medical School, Singapore, Singapore. FAU - Yap, Fabian AU - Yap F AD - Duke-NUS Medical School, Singapore, Singapore. AD - Department of Paediatric Endocrinology, KK Women's and Children's Hospital, Singapore, Singapore. AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. FAU - Lee, Yung Seng AU - Lee YS AD - Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. AD - Division of Paediatric Endocrinology and Diabetes, Children's Medical Institute, Khoo Teck Puat- National University, National University Hospital, National University Health System, Singapore, Singapore. FAU - Eriksson, Johan G AU - Eriksson JG AD - Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. AD - Institute for Human Development and Potential, Agency for Science, Technology, and Research, Singapore, Singapore. AD - Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. AD - Folkhalsan Research Center, Helsinki, Finland. AD - Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. FAU - Chong, Mary F F AU - Chong MFF AD - Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Tahir Foundation Building, 12 Science Drive 2, #09-01Q, 117549, Singapore, Singapore. mary_chong@nus.edu.sg. LA - eng GR - NMRC/TCR/004-NUS/2008; NMRC/TCR/012-NUHS/2014/Singapore Ministry of Health's National Medical Research Council (NMRC)/ GR - NMRC/TCR/004-NUS/2008; NMRC/TCR/012-NUHS/2014/Singapore Ministry of Health's National Medical Research Council (NMRC)/ GR - MC_UU_12011/4/UK Medical Research Council/ GR - RG/15/17/3174/BHF_/British Heart Foundation/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240920 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 SB - IM MH - Adult MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Asian People/statistics & numerical data MH - Cohort Studies MH - *Diet/statistics & numerical data/methods MH - Ethnicity/statistics & numerical data MH - *Feeding Behavior MH - Mothers/statistics & numerical data MH - Singapore MH - Surveys and Questionnaires PMC - PMC11415985 OTO - NOTNLM OT - Dietary pattern trajectories OT - Early childhood OT - GUSTO study OT - Group-based trajectory modelling OT - Maternal feeding practices COIS- The authors declare no competing interests. EDAT- 2024/09/21 16:19 MHDA- 2024/09/21 16:20 PMCR- 2024/09/20 CRDT- 2024/09/20 23:47 PHST- 2023/06/20 00:00 [received] PHST- 2024/09/08 00:00 [accepted] PHST- 2024/09/21 16:20 [medline] PHST- 2024/09/21 16:19 [pubmed] PHST- 2024/09/20 23:47 [entrez] PHST- 2024/09/20 00:00 [pmc-release] AID - 10.1186/s12937-024-01012-5 [pii] AID - 1012 [pii] AID - 10.1186/s12937-024-01012-5 [doi] PST - epublish SO - Nutr J. 2024 Sep 20;23(1):110. doi: 10.1186/s12937-024-01012-5. PMID- 39304751 OWN - NLM STAT- MEDLINE DCOM- 20241105 LR - 20260518 IS - 1476-5640 (Electronic) IS - 0954-3007 (Print) IS - 0954-3007 (Linking) VI - 78 IP - 11 DP - 2024 Nov TI - Anthropometric prediction models of body composition in 3 to 24month old infants: a multicenter international study. PG - 943-951 LID - 10.1038/s41430-024-01501-0 [doi] AB - BACKGROUND: Accurate assessment of body composition during infancy is an important marker of early growth. This study aimed to develop anthropometric models to predict body composition in 3-24-month-old infants from diverse socioeconomic settings and ethnic groups. METHODS: An observational, longitudinal, prospective, multi-country study of infants from 3 to 24 months with body composition assessed at three monthly intervals using deuterium dilution (DD) and anthropometry. Linear mixed modelling was utilized to generate sex-specific fat mass (FM) and fat-free mass (FFM) prediction equations, using length(m), weight-for-length (kg/m), triceps and subscapular skinfolds and South Asian ethnicity as variables. The study sample consisted of 1896 (942 measurements from 310 girls) training data sets, 941 (441 measurements from 154 girls) validation data sets of 3-24 months from Brazil, Pakistan, South Africa and Sri Lanka. The external validation group (test) comprised 349 measurements from 250 (185 from 124 girls) infants 3-6 months of age from South Africa, Australia and India. RESULTS: Sex-specific equations for three age categories (3-9 months; 10-18 months; 19-24 months) were developed, validated on same population and externally validated. Root mean squared error (RMSE) was similar between training, validation and test data for assessment of FM and FFM in boys and in girls. RMSPE and mean absolute percentage error (MAPE) were higher in validation compared to test data for predicting FM, however, in the assessment of FFM, both measures were lower in validation data. RMSE for test data from South Africa (M/F-0.46/0.45 kg) showed good agreement with validation data for assessment of FFM compared to Australia (M/F-0.51/0.33 kg) and India(M/F-0.77/0.80 kg). CONCLUSIONS: Anthropometry-based FFM prediction equations provide acceptable results. Assessments based on equations developed on similar populations are more applicable than those developed from a different population. CI - (c) 2024. The Author(s). FAU - Wickramasinghe, Vithanage Pujitha AU - Wickramasinghe VP AUID- ORCID: 0000-0002-8355-1283 AD - University of Colombo, Colombo, Sri Lanka. pujitha@pdt.cmb.ac.lk. FAU - Ariff, Shabina AU - Ariff S AUID- ORCID: 0000-0002-9627-2662 AD - The Aga Khan University, Karachi, Pakistan. FAU - Norris, Shane A AU - Norris SA AUID- ORCID: 0000-0001-7124-3788 AD - University of the Witwatersrand, Johannesburg, South Africa. FAU - Santos, Ina S AU - Santos IS AUID- ORCID: 0000-0003-1258-9249 AD - Federal University of Pelotas, Pelotas, Brazil. FAU - Kuriyan, Rebecca AU - Kuriyan R AUID- ORCID: 0000-0002-3864-574X AD - St John's Research Institute, Bengaluru, India. FAU - Nyati, Lukhanyo H AU - Nyati LH AD - University of the Witwatersrand, Johannesburg, South Africa. FAU - Varghese, Jithin Sam AU - Varghese JS AD - Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, USA. FAU - Murphy-Alford, Alexia J AU - Murphy-Alford AJ AUID- ORCID: 0000-0001-7095-3796 AD - International Atomic Energy Agency, Vienna, Austria. FAU - Lucas, Nishani AU - Lucas N AUID- ORCID: 0000-0001-7243-7525 AD - University of Colombo, Colombo, Sri Lanka. FAU - Costa, Caroline AU - Costa C AD - Federal University of Pelotas, Pelotas, Brazil. FAU - Ahuja, Kiran D K AU - Ahuja KDK AD - University of Tasmania, Hobart, Australia. FAU - Jayasinghe, S AU - Jayasinghe S AUID- ORCID: 0000-0001-8805-385X AD - University of Tasmania, Hobart, Australia. FAU - Kurpad, Anura V AU - Kurpad AV AUID- ORCID: 0000-0001-7998-2438 AD - St John's Research Institute, Bengaluru, India. FAU - Hills, Andrew P AU - Hills AP AUID- ORCID: 0000-0002-7787-7201 AD - University of Tasmania, Hobart, Australia. CN - Multi-center Infant Body Composition Reference Study (MIBCRS) LA - eng GR - OPP1143641/Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation)/ GR - CRP E43028/International Atomic Energy Agency (IAEA)/ PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20240920 PL - England TA - Eur J Clin Nutr JT - European journal of clinical nutrition JID - 8804070 SB - IM MH - Humans MH - Infant MH - Male MH - Female MH - *Body Composition MH - Prospective Studies MH - *Anthropometry/methods MH - Longitudinal Studies MH - Child, Preschool MH - Australia MH - India MH - South Africa MH - Brazil PMC - PMC11537960 COIS- Rebecca Kuriyan is an Associate Editor for The European Journal of Clinical Nutrition and played no role in the Journal's evaluation of the manuscript. Other authors declare no competing interests, FIR - Wickramasinghe, V Pujitha IR - Wickramasinghe VP FIR - Murphy-Alford, Alexia IR - Murphy-Alford A FIR - Nyati, Lukhanyo IR - Nyati L FIR - Costa, Caroline S IR - Costa CS FIR - Ahmad, Tanvir IR - Ahmad T FIR - Beckett, Jeff M IR - Beckett JM FIR - Bielemann, Renata M IR - Bielemann RM FIR - Byrne, Nuala M IR - Byrne NM FIR - Charania, Laila IR - Charania L FIR - Christian, Michele Peresh IR - Christian MP FIR - Divya, Priscilla J IR - Divya PJ FIR - Hanley, Anne IR - Hanley A FIR - Herath, Manoja P IR - Herath MP FIR - Ismail, Leila I Cheikh IR - Ismail LIC FIR - Jayasinghe, Sisitha IR - Jayasinghe S FIR - Lanerolle, Pulani IR - Lanerolle P FIR - Loechl, Cornelia IR - Loechl C FIR - Mokhtar, Najat IR - Mokhtar N FIR - Senerath, Upul IR - Senerath U FIR - Slater, Christine IR - Slater C FIR - Soofi, Sajid IR - Soofi S FIR - Street, Steven J IR - Street SJ FIR - Valle, Neiva C J IR - Valle NCJ FIR - Yameen, Ayesha IR - Yameen A EDAT- 2024/09/21 16:19 MHDA- 2024/11/06 00:22 PMCR- 2024/09/20 CRDT- 2024/09/20 23:38 PHST- 2023/06/03 00:00 [received] PHST- 2024/08/21 00:00 [accepted] PHST- 2024/07/22 00:00 [revised] PHST- 2024/11/06 00:22 [medline] PHST- 2024/09/21 16:19 [pubmed] PHST- 2024/09/20 23:38 [entrez] PHST- 2024/09/20 00:00 [pmc-release] AID - 10.1038/s41430-024-01501-0 [pii] AID - 1501 [pii] AID - 10.1038/s41430-024-01501-0 [doi] PST - ppublish SO - Eur J Clin Nutr. 2024 Nov;78(11):943-951. doi: 10.1038/s41430-024-01501-0. Epub 2024 Sep 20. PMID- 39303625 OWN - NLM STAT- MEDLINE DCOM- 20241116 LR - 20241211 IS - 1476-5616 (Electronic) IS - 0033-3506 (Linking) VI - 236 DP - 2024 Nov TI - The Perceived Weight Stigma Scale and Weight Self-Stigma Questionnaire: Rasch analysis, confirmatory factor analysis, and network analysis among Chinese adolescents. PG - 373-380 LID - S0033-3506(24)00363-9 [pii] LID - 10.1016/j.puhe.2024.08.016 [doi] AB - OBJECTIVES: The objectives of the present study were to (i) re-evaluate and expand the psychometric properties of two weight stigma instruments-the Perceived Weight Stigma Scale (PWSS) and the Weight Self-Stigma Questionnaire (WSSQ) among a large sample of adolescents using advanced psychometric methods and (ii) examine how the different types of weight stigma (i.e., PWSS and WSSQ) are associated with psychological distress. STUDY DESIGN: Cross-sectional study. METHODS: In September 2023, a cross-sectional survey utilising convenience sampling was used to recruit 9995 adolescents (mean age = 16.36 years [standard deviation = 0.78]; 57.8% males). They completed the PWSS, WSSQ, and a measure on psychological distress. The data were analysed using Rasch analysis, confirmatory factor analysis (CFA), structural equation modelling (SEM), and network analysis. RESULTS: The CFA and Rasch model results showed acceptable psychometric properties regarding factor structure, factor loading, difficulty, and infit and outfit mean squares (except Items 4 and 7 of the PWSS). There was no substantial differential item functioning for any tested items across the sex and weight categories. The CFA and SEM results showed promising validity indices with significant associations between both weight stigma scales and psychological distress (i.e., depression, anxiety, and stress). Network analysis showed inter-variable connectivity between nodes PWSS3 ("People act as if they are afraid of you") and WSSQF7 ("I feel insecure about others' opinions of me"). CONCLUSIONS: Both weight stigma scales had acceptable psychometric properties and were significantly associated with psychological distress, although each assessed different types of weight stigma. This suggests that researchers and clinicians can use these scales to reliably and validly assess weight stigmas among adolescents. CI - Copyright (c) 2024 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved. FAU - Ahorsu, Daniel Kwasi AU - Ahorsu DK AD - Department of Special Education and Counselling, The Education University of Hong Kong, 10 Lo Ping Road, Tai Po, N.T, Hong Kong. Electronic address: dkahorsu@eduhk.hk. FAU - Chen, Chao-Ying AU - Chen CY AD - School of Physical Therapy and Graduate Institute of Rehabilitation Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan; New Taipei City Tucheng Hospital (Chang Gung Medical Foundation), Department of Pediatric Internal Medicine, New Taipei City, Taiwan. Electronic address: chao-ying.chen@gap.cgu.edu.tw. FAU - Chen, I-Hua AU - Chen IH AD - Chinese Academy of Education Big Data, Qufu Normal University, Qufu, 273165, China. Electronic address: aholechen@gmail.com. FAU - Pakpour, Amir H AU - Pakpour AH AD - Department of Nursing, School of Health and Welfare, Jonkoping University, Halsohogskolan, Jonkoping 55318, Sweden. Electronic address: Amir.Pakpour@ju.se. FAU - Bevan, Nadia AU - Bevan N AD - School of Social Sciences, Monash University, 20 Chancellors Walk, Clayton VIC 3800, Australia. Electronic address: nadia.bevan@monash.edu. FAU - Chen, Jung-Sheng AU - Chen JS AD - Department of Medical Research, E-Da Hospital, I-Shou University, 1 Yi-Da Rd., Yanchao Dist., Kaohsiung 824005, Taiwan. Electronic address: nicky071214@gmail.com. FAU - Wang, Xue Lian AU - Wang XL AD - Yancheng Mechatronic Branch of Jiangsu Union Technical Institute, Yancheng, 224006, China; International College, Krirk University, Bangkok, 10110, Thailand. Electronic address: 412901508@qq.com. FAU - Ko, Po-Jui AU - Ko PJ AD - Department of Surgery, Division of Pediatric Surgery, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan; Department of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan. Electronic address: ed106790@edah.org.tw. FAU - Griffiths, Mark D AU - Griffiths MD AD - International Gaming Research Unit, Psychology Department, Nottingham Trent University, Nottingham, UK. Electronic address: mark.griffiths@ntu.ac.uk. FAU - Lin, Chung-Ying AU - Lin CY AD - Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, 1 University Rd., Tainan 701401, Taiwan; Biostatistics Consulting Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 1 University Rd., Tainan 701401, Taiwan; Department of Public Health, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 1 University Rd., Tainan 701401, Taiwan; Department of Occupational Therapy, College of Medicine, National Cheng Kung University, 1 University Rd., Tainan 701401, Taiwan. Electronic address: cylin36933@gmail.com. LA - eng PT - Journal Article DEP - 20240919 PL - Netherlands TA - Public Health JT - Public health JID - 0376507 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - *Psychometrics MH - *Social Stigma MH - Cross-Sectional Studies MH - Surveys and Questionnaires/standards MH - Factor Analysis, Statistical MH - China MH - Body Weight MH - Reproducibility of Results MH - Psychological Distress MH - Self Concept MH - East Asian People OTO - NOTNLM OT - Adolescents OT - Confirmatory factor analysis OT - Network analysis OT - Perceived weight stigma OT - Rasch analysis OT - Weight self-stigma EDAT- 2024/09/21 11:44 MHDA- 2024/11/16 22:25 CRDT- 2024/09/20 18:09 PHST- 2024/02/02 00:00 [received] PHST- 2024/07/03 00:00 [revised] PHST- 2024/08/15 00:00 [accepted] PHST- 2024/11/16 22:25 [medline] PHST- 2024/09/21 11:44 [pubmed] PHST- 2024/09/20 18:09 [entrez] AID - S0033-3506(24)00363-9 [pii] AID - 10.1016/j.puhe.2024.08.016 [doi] PST - ppublish SO - Public Health. 2024 Nov;236:373-380. doi: 10.1016/j.puhe.2024.08.016. Epub 2024 Sep 19. PMID- 39300665 OWN - NLM STAT- MEDLINE DCOM- 20240920 LR - 20260813 IS - 1938-3207 (Electronic) IS - 0002-9165 (Print) IS - 0002-9165 (Linking) VI - 120 Suppl 1 IP - Suppl 1 DP - 2024 Sep TI - Biomarker relationships with small bowel histopathology among malnourished children with environmental enteric dysfunction in a multicountry cohort study. PG - S73-S83 LID - S0002-9165(24)00272-7 [pii] LID - 10.1016/j.ajcnut.2024.02.029 [doi] AB - BACKGROUND: Validated biomarkers could catalyze environmental enteric dysfunction (EED) research. OBJECTIVES: Leveraging an EED histology scoring system, this multicountry analysis examined biomarker associations with duodenal histology features among children with EED. We also examined differences in 2-h compared with 1-h urine collections in the lactulose rhamnose (LR) dual sugar test. METHODS: Three cohorts of undernourished children unresponsive to nutrition intervention underwent esophagogastroduodenoscopy and duodenal biopsies. Histopathology scores were compared to fecal calprotectin (CAL), myeloperoxidase (MPO), neopterin (NEO), and urinary LR ratio and lactulose percentage recovery. Log-transformed biomarkers were used in linear regressions adjusted for age, center, and sample collection-biopsy time interval in multivariable models. RESULTS: Data on >1 biomarker were available for 120 Bangladeshi (CAL, MPO, NEO, and LR), 63 Pakistani (MPO, NEO, and LR), and 63 Zambian children (CAL). Median age at endoscopy was similar (19 mo) across centers. Median sample collection prior to endoscopy was consistent with each center's study design: 2 wk in Bangladesh (urine and stool) and Zambia (stool), and 6 (urine) and 11 (stool) mo in Pakistan. In multivariable models, intraepithelial lymphocytes were associated with CAL (exponentiated [exp.] coefficient: 1.19; 95% confidence interval [CI]: 1, 1.41), intramucosal Brunner's glands with MPO (exp. coefficient: 1.33; 95% CI: 1.05, 1.69) and NEO (exp. coefficient: 1.37; 95% CI: 1.1, 1.7), and chronic inflammation with NEO (exp. coefficient: 1.61; 95% CI: 1.17, 2.17). Intraepithelial lymphocytes were associated with lactulose % recovery (exp. coefficient: 1.22; 95% CI: 1.05, 1.41). LR recovery was substantially lower in 1-h collections than in 2-h collections. CONCLUSIONS: Four commonly used markers of enteric dysfunction were associated with specific histologic features. One-hour urine collection may be insufficient to reflect small bowel permeability in LR testing. While acknowledging the challenges with obtaining relevant tissue, these findings form the basis for further EED biomarker validation research. CI - Copyright (c) 2024 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Mahfuz, Mustafa AU - Mahfuz M AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. Electronic address: mustafa@icddrb.org. FAU - Coomes, David AU - Coomes D AD - Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, United States. FAU - Abdalla, Marwa AU - Abdalla M AD - Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, United States. FAU - Mweetwa, Monica AU - Mweetwa M AD - Tropical Gastroenterology & Nutrition Group, University of Zambia School of Medicine, Lusaka, Zambia. FAU - VanBuskirk, Kelley AU - VanBuskirk K AD - Department of Global Health, University of Washington School of Public Health, Seattle, WA, United States. FAU - Iqbal, Najeeha T AU - Iqbal NT AD - Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. FAU - Ali, S Asad AU - Ali SA AD - Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. FAU - Chandwe, Kanta AU - Chandwe K AD - Tropical Gastroenterology & Nutrition Group, University of Zambia School of Medicine, Lusaka, Zambia. FAU - Das, Subhasish AU - Das S AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. FAU - Kelly, Paul AU - Kelly P AD - Blizard Institute, Barts & The London School of Medicine, Queen Mary University of London, London, United Kingdom. FAU - Shaikh, Nurmohammad AU - Shaikh N AD - Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, United States. FAU - Tarr, Phillip I AU - Tarr PI AD - Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, United States. FAU - Denno, Donna M AU - Denno DM AD - Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, United States. Electronic address: ddenno@uw.edu. CN - EEDBI Consortium LA - eng GR - P30 DK052574/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Multicenter Study PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 RN - 0 (Biomarkers) RN - 4618-18-2 (Lactulose) RN - 0 (Leukocyte L1 Antigen Complex) RN - 670-65-5 (Neopterin) RN - EC 1.11.1.7 (Peroxidase) SB - IM MH - Humans MH - *Biomarkers/urine MH - Female MH - Male MH - Infant MH - Cohort Studies MH - Child, Preschool MH - Feces/chemistry MH - Intestine, Small/pathology MH - Lactulose/urine MH - Child Nutrition Disorders/pathology MH - Bangladesh MH - Leukocyte L1 Antigen Complex/analysis MH - Zambia MH - Neopterin/urine MH - Peroxidase/metabolism MH - Malnutrition PMC - PMC13169017 OTO - NOTNLM OT - EED OT - biomarkers OT - children OT - intestinal inflammation OT - intestinal permeability OT - low-resource settings FIR - Ahmed, Kumail IR - Ahmed K IRAD- Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: kumail.ahmed@aku.edu. FIR - Ahmed, Sheraz IR - Ahmed S IRAD- Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: sheraz.ahmed@aku.edu. FIR - Ahmed, Tahmeed IR - Ahmed T IRAD- International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. Electronic address: tahmeed@icddrb.org. FIR - Alam, Md Ashraful IR - Alam MA IRAD- International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. Electronic address: mashraful@icddrb.org. FIR - Amadi, Beatrice IR - Amadi B IRAD- Tropical Gastroenterology and Nutrition Group, University of Zambia School of Medicine, Lusaka, Zambia. Electronic address: beatriceamadi@ymail.com. FIR - Begum, S M Khodeza Nahar IR - Begum SMKN IRAD- Department of Pathology, Bangladesh Specialized Hospital, Dhaka, Bangladesh. Electronic address: khodeza33@hotmail.com. FIR - Besa, Ellen IR - Besa E IRAD- Tropical Gastroenterology & Nutrition group, University of Zambia School of Medicine, Lusaka, Zambia. Electronic address: ellen@tropgan.net. FIR - Fahim, Shah Mohammad IR - Fahim SM IRAD- International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. Electronic address: mohammad.fahim@icddrb.org. FIR - Gazi, Md Amran IR - Gazi MA IRAD- International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. Electronic address: amran.gazi@icddrb.org. FIR - Gilchrist, Carol A IR - Gilchrist CA IRAD- Department of Medicine, University of Virginia, Charlottesville, Virginia, USA. Electronic address: cg2p@virginia.edu. FIR - Haque, Rashidul IR - Haque R IRAD- Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. Electronic address: rhaque@icddrb.org. FIR - Hasan, Md Mehedi IR - Hasan MM IRAD- International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. Electronic address: md.hasan@icddrb.org. FIR - Hossain, Md Shabab IR - Hossain MS IRAD- International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. Electronic address: dr.shabab@icddrb.org. FIR - Hotwani, Aneeta IR - Hotwani A IRAD- Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: aneeta.hotwani@aku.edu. FIR - Hussain, Shahneel IR - Hussain S IRAD- Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan. Electronic address: shahneel.hussain@aku.edu. FIR - Iqbal, Junaid IR - Iqbal J IRAD- Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: junaid.iqbal@aku.edu. FIR - Jakhro, Sadaf IR - Jakhro S IRAD- Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: sadaf.jakhro@aku.edu. FIR - Kabir, Furqan IR - Kabir F IRAD- Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: furqan.kabir@aku.edu. FIR - Liu, Ta-Chiang IR - Liu TC IRAD- Department of Pathology and Immunology, Washington University, St. Louis, MO, USA. Electronic address: ta-chiang.liu@wustl.edu. FIR - Mann, Barbara J IR - Mann BJ IRAD- Department of Medicine, University of Virginia, Charlottesville, Virginia, USA. Electronic address: bjm2r@virginia.edu. FIR - Mazumder, Ramendra Nath IR - Mazumder RN IRAD- International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. Electronic address: ramen@icddrb.org. FIR - Memon, Waheeda IR - Memon W IRAD- Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: waheeda.memon@aku.edu. FIR - Moskaluk, Christopher A IR - Moskaluk CA IRAD- Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA, USA. Electronic address: cam5p@virginia.edu. FIR - Qureshi, Abdul Khalique IR - Qureshi AK IRAD- Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: abdul.qureshi@aku.edu. FIR - Ragahavan, Shyam S IR - Ragahavan SS IRAD- Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA, USA. Electronic address: SR7WQ@hscmail.mcc.virginia.edu. FIR - Rahman, Masudur IR - Rahman M IRAD- Department of Gastroenterology, Sheikh Russel National Gastroliver Institute and Hospital, Dhaka, Bangladesh. Electronic address: drmasud47@yahoo.com. FIR - Rahman, Najeeb IR - Rahman N IRAD- Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: najeeb.rahman@aku.edu. FIR - Sadiq, Kamran IR - Sadiq K IRAD- Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: kamran.sadiq@aku.edu. FIR - Sarker, Shafiqul Alam IR - Sarker SA IRAD- International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. Electronic address: sasarker@icddrb.org. FIR - Sullivan, Peter B IR - Sullivan PB IRAD- Department of Paediatrics, Children's Hospital, University of Oxford, Oxford, UK. Electronic address: peter.sullivan@paediatrics.ox.ac.uk. FIR - Tearney, Guillermo J IR - Tearney GJ IRAD- Department of Pathology, Harvard Medical School, Boston, MA, USA. Electronic address: gtearney@partners.org. FIR - Umrani, Fayaz IR - Umrani F IRAD- Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: fayaz.umrani@aku.edu. FIR - Yilmaz, Omer H IR - Yilmaz OH IRAD- Department of Pathology, Massachusetts General Hospital, Boston, MA, USA. Electronic address: oyilmaz@mgh.harvard.edu. FIR - Zyambo, Kanekwa IR - Zyambo K IRAD- Tropical Gastroenterology & Nutrition group, University of Zambia School of Medicine, Lusaka, Zambia. Electronic address: kanekwa@tropgan.net. EDAT- 2024/09/21 13:19 MHDA- 2024/09/21 13:20 PMCR- 2024/09/17 CRDT- 2024/09/20 00:08 PHST- 2023/09/05 00:00 [received] PHST- 2024/02/12 00:00 [revised] PHST- 2024/02/22 00:00 [accepted] PHST- 2024/09/21 13:20 [medline] PHST- 2024/09/21 13:19 [pubmed] PHST- 2024/09/20 00:08 [entrez] PHST- 2024/09/17 00:00 [pmc-release] AID - S0002-9165(24)00272-7 [pii] AID - 10.1016/j.ajcnut.2024.02.029 [doi] PST - ppublish SO - Am J Clin Nutr. 2024 Sep;120 Suppl 1(Suppl 1):S73-S83. doi: 10.1016/j.ajcnut.2024.02.029. PMID- 39300660 OWN - NLM STAT- MEDLINE DCOM- 20240920 LR - 20260813 IS - 1938-3207 (Electronic) IS - 0002-9165 (Print) IS - 0002-9165 (Linking) VI - 120 Suppl 1 IP - Suppl 1 DP - 2024 Sep TI - Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with United States children. PG - S15-S30 LID - S0002-9165(24)00271-5 [pii] LID - 10.1016/j.ajcnut.2024.02.028 [doi] AB - BACKGROUND: Environmental enteric dysfunction (EED) is an asymptomatic intestinal disorder associated with growth impairment, delayed neurocognitive development, and impaired oral vaccine responses. OBJECTIVES: We set out to develop and validate a histopathologic scoring system on duodenal biopsies from a cohort study of children with growth failure in Bangladesh, Pakistan, and Zambia ("EED") with reference to biopsies from United States children with no clinically reported histologic pathology (referred to hereafter as "normal") or celiac disease. METHODS: Five gastrointestinal pathologists evaluated 745 hematoxylin and eosin slide images from 291 children with EED (mean age: 1.6 y) and 66 United States children (mean age: 6.8 y). Histomorphologic features (i.e., villus/crypt architecture, goblet cells, epithelial and lamina propria acute/chronic inflammation, Brunner's glands, Paneth cells, epithelial detachment, enterocyte injury, and foveolar metaplasia) were used to score each histopathologic slide. Generalized estimating equations were used to determine differences between EED, normal, and celiac disease, and receiver operating characteristic curves were used to assess predictive value. RESULTS: Biopsies from the duodenal bulb showed higher intramucosal Brunner's gland scores and lower intraepithelial lymphocyte scores than from the second or third parts of the duodenum (D2/3), so only D2/3 were included in the final analysis. Although 7 parameters differed significantly between EED and normal biopsies in regression models, only 5 (blunted villus architecture, increased intraepithelial lymphocytosis, goblet cell depletion, Paneth cell depletion, and reduced intramucosal Brunner's glands) were required to create a total score percentage (TSP-5) that correctly identified EED against normal biopsies (AUC: 0.992; 95% CI: 0.983, 0.998). Geographic comparisons showed more severe goblet cell depletion in Bangladesh and more marked intraepithelial lymphocytosis in Pakistan. CONCLUSIONS: This scoring system involving 5 histologic parameters demonstrates very high discrimination between EED and normal biopsies, indicating that this scoring system can be applied with confidence to studies of intestinal biopsies in EED. CI - Copyright (c) 2024 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Kelly, Paul AU - Kelly P AD - Blizard Institute, Barts & The London School of Medicine, Queen Mary University of London, London, United Kingdom. Electronic address: m.p.kelly@qmul.ac.uk. FAU - VanBuskirk, Kelley AU - VanBuskirk K AD - Department of Global Health, University of Washington School of Public Health, Seattle, WA, United States. FAU - Coomes, David AU - Coomes D AD - Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, United States. FAU - Mouksassi, Samer AU - Mouksassi S AD - Certara, Princeton, NJ, United States. FAU - Smith, Gerald AU - Smith G AD - Cytel, Vancouver, British Columbia, Canada. FAU - Jamil, Zehra AU - Jamil Z AD - Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan. FAU - Hossain, Md Shabab AU - Hossain MS AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. FAU - Syed, Sana AU - Syed S AD - Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, United States. FAU - Marie, Chelsea AU - Marie C AD - Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, United States. FAU - Tarr, Phillip I AU - Tarr PI AD - Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, United States. FAU - Sullivan, Peter B AU - Sullivan PB AD - Department of Paediatrics, Children's Hospital, University of Oxford, Oxford, United Kingdom. FAU - Petri, William A Jr AU - Petri WA Jr AD - Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, United States. FAU - Denno, Donna M AU - Denno DM AD - Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, United States. FAU - Ahmed, Tahmeed AU - Ahmed T AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. FAU - Mahfuz, Mustafa AU - Mahfuz M AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. FAU - Ali, S Asad AU - Ali SA AD - Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. FAU - Moore, Sean R AU - Moore SR AD - Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, United States. FAU - Ndao, I Malick AU - Ndao IM AD - Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, United States. FAU - Tearney, Guillermo J AU - Tearney GJ AD - Department of Pathology, Harvard Medical School, Boston, MA, United States. FAU - Omer H Yilmaz AU - Omer H Yilmaz AD - Department of Pathology, Massachusetts General Hospital, Boston, MA, United States. FAU - Raghavan, Shyam S AU - Raghavan SS AD - Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA, United States. FAU - Moskaluk, Christopher A AU - Moskaluk CA AD - Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA, United States. FAU - Liu, Ta-Chiang AU - Liu TC AD - Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States. CN - EEDBI Consortium LA - eng GR - P30 DK052574/DK/NIDDK NIH HHS/United States PT - Comparative Study PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Humans MH - Bangladesh/epidemiology MH - Pakistan/epidemiology MH - Zambia/epidemiology MH - Cohort Studies MH - Child MH - Female MH - Male MH - Infant MH - Child, Preschool MH - *Duodenum/pathology MH - United States/epidemiology MH - Biopsy MH - Intestinal Diseases/pathology MH - Celiac Disease/pathology MH - Intestinal Mucosa/pathology MH - Goblet Cells/pathology MH - Child Nutrition Disorders/epidemiology/pathology PMC - PMC13168970 OTO - NOTNLM OT - Paneth cells OT - child health OT - crypts OT - enteropathy OT - global health OT - goblet cells OT - intestine OT - malnutrition OT - stunting OT - villi FIR - Ahmed, Kumail IR - Ahmed K IRAD- Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: kumail.ahmed@aku.edu. FIR - Ahmed, Sheraz IR - Ahmed S IRAD- Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: sheraz.ahmed@aku.edu. FIR - Alam, Md Ashraful IR - Alam MA IRAD- International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. Electronic address: mashraful@icddrb.org. FIR - Begum, S M Khodeza Nahar IR - Begum SMKN IRAD- Department of Pathology, Bangladesh Specialized Hospital, Dhaka, Bangladesh. Electronic address: khodeza33@hotmail.com. FIR - Besa, Ellen IR - Besa E IRAD- Tropical Gastroenterology & Nutrition group, University of Zambia School of Medicine, Lusaka, Zambia. Electronic address: ellen@tropgan.net. FIR - Chandwe, Kanta IR - Chandwe K IRAD- Tropical Gastroenterology & Nutrition group, University of Zambia School of Medicine, Lusaka, Zambia. Electronic address: kantachandwe@gmail.com. FIR - Chipunza, Miyoba IR - Chipunza M IRAD- Tropical Gastroenterology & Nutrition group, University of Zambia School of Medicine, Lusaka, Zambia. Electronic address: miyobachipunza@gmail.com. FIR - Das, Subhasish IR - Das S IRAD- International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. Electronic address: subhasish.das@icddrb.org. FIR - Denson, Lee A IR - Denson LA IRAD- Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address: Lee.Denson@cchmc.org. FIR - Fahim, Shah Mohammad IR - Fahim SM IRAD- International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. Electronic address: mohammad.fahim@icddrb.org. FIR - Gazi, Md Amran IR - Gazi MA IRAD- International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. Electronic address: amran.gazi@icddrb.org. FIR - Hasan, Md Mehedi IR - Hasan MM IRAD- International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. Electronic address: md.hasan@icddrb.org. FIR - Hotwani, Aneeta IR - Hotwani A IRAD- Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: aneeta.hotwani@aku.edu. FIR - Iqbal, Junaid IR - Iqbal J IRAD- Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: junaid.iqbal@aku.edu. FIR - Iqbal, Najeeha Talat IR - Iqbal NT IRAD- Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan. Electronic address: najeeha.iqbal@aku.edu. FIR - Jakhro, Sadaf IR - Jakhro S IRAD- Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: sadaf.jakhro@aku.edu. FIR - Kabir, Furqan IR - Kabir F IRAD- Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: furqan.kabir@aku.edu. FIR - Lawrence, Sarah IR - Lawrence S IRAD- Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA. Electronic address: Slawrence0008@gmail.com. FIR - Mann, Barbara J IR - Mann BJ IRAD- Department of Medicine, University of Virginia, Charlottesville, Virginia, USA. Electronic address: bjm2r@virginia.edu. FIR - Mazumder, Ramendra Nath IR - Mazumder RN IRAD- International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. Electronic address: ramen@icddrb.org. FIR - Memon, Waheeda IR - Memon W IRAD- Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: waheeda.memon@aku.edu. FIR - Morgan, Brooks IR - Morgan B IRAD- Department of Epidemiology, University of Washington School of Public Health, Seattle, USA. Electronic address: bwmorgan@uw.edu. FIR - Mudenda, Victor IR - Mudenda V IRAD- Tropical Gastroenterology & Nutrition group, University of Zambia School of Medicine, Lusaka, Zambia. Electronic address: mudenda2003@yahoo.co.uk. FIR - Mulenga, Chola IR - Mulenga C IRAD- Tropical Gastroenterology & Nutrition group, University of Zambia School of Medicine, Lusaka, Zambia. Electronic address: cholamulenga94@gmail.com. FIR - Mweetwa, Monica IR - Mweetwa M IRAD- Tropical Gastroenterology & Nutrition group, University of Zambia School of Medicine, Lusaka, Zambia. Electronic address: monica@tropgan.net. FIR - Qureshi, Abdul Khalique IR - Qureshi AK IRAD- Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: abdul.qureshi@aku.edu. FIR - Rahman, Masudur IR - Rahman M IRAD- Department of Gastroenterology, Sheikh Russel National Gastroliver Institute and Hospital, Dhaka, Bangladesh. Electronic address: drmasud47@yahoo.com. FIR - Rahman, Najeeb IR - Rahman N IRAD- Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: najeeb.rahman@aku.edu. FIR - Sadiq, Kamran IR - Sadiq K IRAD- Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: kamran.sadiq@aku.edu. FIR - Sarker, Shafiqul Alam IR - Sarker SA IRAD- International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. Electronic address: sasarker@icddrb.org. FIR - Umrani, Fayaz IR - Umrani F IRAD- Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: fayaz.umrani@aku.edu. FIR - Zyambo, Kanekwa IR - Zyambo K IRAD- Tropical Gastroenterology & Nutrition group, University of Zambia School of Medicine, Lusaka, Zambia. Electronic address: kanekwa@tropgan.net. EDAT- 2024/09/21 13:19 MHDA- 2024/09/21 13:20 PMCR- 2024/09/17 CRDT- 2024/09/20 00:08 PHST- 2023/09/06 00:00 [received] PHST- 2024/02/19 00:00 [revised] PHST- 2024/02/22 00:00 [accepted] PHST- 2024/09/21 13:20 [medline] PHST- 2024/09/21 13:19 [pubmed] PHST- 2024/09/20 00:08 [entrez] PHST- 2024/09/17 00:00 [pmc-release] AID - S0002-9165(24)00271-5 [pii] AID - 10.1016/j.ajcnut.2024.02.028 [doi] PST - ppublish SO - Am J Clin Nutr. 2024 Sep;120 Suppl 1(Suppl 1):S15-S30. doi: 10.1016/j.ajcnut.2024.02.028. PMID- 39299048 OWN - NLM STAT- MEDLINE DCOM- 20241107 LR - 20250728 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 128 DP - 2024 Dec TI - Association between consumption of non-nutritive sweeteners and gestational diabetes mellitus in Chilean pregnant women: A secondary data analysis of the CHiMINCs-II cohort. PG - 112560 LID - S0899-9007(24)00209-0 [pii] LID - 10.1016/j.nut.2024.112560 [doi] AB - OBJECTIVE: To evaluate the association between consumed non-nutritive sweeteners (NNS) and gestational diabetes mellitus (GDM) in a cohort of pregnant women from Santiago, Chile. METHODS: This secondary data analysis of a cohort.involved 1,472 pregnant women from the Chilean Maternal-Infant Cohort Study-II (CHiMINCs-II). These women received care at primary health care centers in Puente Alto county, South-Eastern Metropolitan Health Service of Santiago, Chile. NNS consumption was estimated using 24-h dietary recalls and linked to the packaged foods nutrition facts panel. Plasma glucose values were extracted from clinical records. GDM was defined according to national criteria: 1) fasting plasma glucose (FPG) >/=100 and <126 mg/dL at the first antenatal visit; 2) FPG >/=100 mg/dL or 2-hour plasma glucose >/=140 mg/dL in the 75 g oral glucose tolerance test at 24-28 weeks. Cases with a GDM diagnosis in their medical records were also considered regardless of test results. The association between each NNS and GDM was assessed using logistic regression models. RESULTS: A total of 77.8% of the participants consumed NNS. The most consumed was sucralose (66%), followed by acesulfame-K (43.6%), and steviol glycosides (41.1%). Beverages (82%), dairy (12.4%) and candy products (4.4%) were the primary dietary sources of NNS. The GDM incidence was 18.9%, higher among consumers of any NNS compared to non-consumers (20.3% vs. 14.2%, p < 0.05). The adjusted model showed a significant association between the consumption of any NNS and sucralose and the risk of GDM (OR for any NNS = 1.58; 95% CI: 1.10-2.26; P = 0.014; OR sucralose = 1.44; 95% CI 1.06-1.95; P = 0.020). CONCLUSIONS: The consumption of NNS, particularly sucralose, is associated with an increased risk of GDM in pregnant women. Further studies are essential to validate these results in other contexts and to guide future recommendations for healthier dietary practices among pregnant populations. CI - Copyright (c) 2024 Elsevier Inc. All rights reserved. FAU - Campos, Paola AU - Campos P AD - Center for Research in Food Environments and Prevention of Nutrition-Related Chronic Diseases (CIAPEC)(,) Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile. FAU - Rebolledo, Natalia AU - Rebolledo N AD - Center for Research in Food Environments and Prevention of Nutrition-Related Chronic Diseases (CIAPEC)(,) Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile. FAU - Duran, Samuel AU - Duran S AD - Faculty of Health Sciences, Universidad San Sebastian, Santiago, Chile. FAU - Flores, Marcela AU - Flores M AD - Municipal Health Corporation of Puente Alto, Santiago, Chile. FAU - Reyes, Marcela AU - Reyes M AD - Center for Research in Food Environments and Prevention of Nutrition-Related Chronic Diseases (CIAPEC)(,) Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile. FAU - Garmendia, Maria Luisa AU - Garmendia ML AD - Center for Research in Food Environments and Prevention of Nutrition-Related Chronic Diseases (CIAPEC)(,) Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile. Electronic address: mgarmendia@inta.uchile.cl. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240907 PL - United States TA - Nutrition JT - Nutrition (Burbank, Los Angeles County, Calif.) JID - 8802712 RN - 0 (Non-Nutritive Sweeteners) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - Female MH - *Diabetes, Gestational/epidemiology/etiology MH - Pregnancy MH - Chile/epidemiology MH - Adult MH - *Non-Nutritive Sweeteners/adverse effects/administration & dosage MH - Cohort Studies MH - *Blood Glucose/analysis MH - Glucose Tolerance Test MH - Young Adult MH - Diet/methods/statistics & numerical data MH - Risk Factors MH - Secondary Data Analysis OTO - NOTNLM OT - Artificial sweeteners OT - Gestational diabetes OT - Glucose metabolism OT - Non-nutritive sweeteners OT - Pregnancy OT - Sucralose COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/09/20 11:25 MHDA- 2024/11/13 13:54 CRDT- 2024/09/19 18:07 PHST- 2024/04/08 00:00 [received] PHST- 2024/07/18 00:00 [revised] PHST- 2024/07/23 00:00 [accepted] PHST- 2024/11/13 13:54 [medline] PHST- 2024/09/20 11:25 [pubmed] PHST- 2024/09/19 18:07 [entrez] AID - S0899-9007(24)00209-0 [pii] AID - 10.1016/j.nut.2024.112560 [doi] PST - ppublish SO - Nutrition. 2024 Dec;128:112560. doi: 10.1016/j.nut.2024.112560. Epub 2024 Sep 7. PMID- 39298496 OWN - NLM STAT- MEDLINE DCOM- 20240923 LR - 20260923 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 9 DP - 2024 TI - A retrospective characterization of pediatric facemasks marketed in the United States and implications for future designs. PG - e0307879 LID - 10.1371/journal.pone.0307879 [doi] LID - e0307879 AB - BACKGROUND: Device manufacturers who seek to market their pediatric facemasks in the United States (U.S.), as part of anthropometric data requirement, need to demonstrate their mask designs are expected to fit the intended user population. However, currently there are no well accepted test methodologies for pediatric facemasks. In addition, unlike N95 respirators, the expected maximum flow rate, and the pressure drop at that expected maximum flow rate for pediatric facemasks have not been established. METHOD: The objective of this article is three-fold; use a literature survey to determine the worst-case flow rate, and an acceptable breathing resistance; and come up with a bench-test based protocol for assessing fit of pediatric facemasks. RESULTS & DISCUSSION: The worst-case breathing flow rate for mask testing in the pediatric population is 45-60 Liters/minute (LPM), and the acceptable pressure drop at the worst-case flow rate is 2.0 mmH2O. A retrospective assessment of all the four brands of legally marketed facemasks in the U.S. that could be purchased, revealed that majority of the brands have high filtration efficiency (>95%) at low flow rate 5 LPM which reduces to ~ 80% at 45 LPM. At 5 LPM, the pressure drop ranges from 0.3-0.6 mmH2O, remaining below the 2.0 mmH2O. However, at higher flow rates, (representing strenuous activities, or older children (> 12 years)), most masks exhibited a pressure drop within the range of 2.9 to 6.0 mmH2O. Furthermore, opening the pleats of the facemasks completely results in a notable reduction in pressure drop (a 6.6-fold decrease, p = 0.03). To assess fit of these same brands of facemasks, we then updated our previous validated adult manikin fit-test method and used it in manikins in the age group of 2 to 14 years. Either poor nose-clip adherence to the manikin, low filtration efficiency of the pediatric facemasks, or off-label use (i.e. when donned on manikins representing 2 years to 14 years) contributed to low fit. CONCLUSIONS: A new bench-top tool to evaluate quantitative fit of pediatric facemasks was developed. In addition, based on the research reported here, we provide practical implications for the members of the community: users, academia and medical device manufacturers. CI - Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. FAU - Hasani, Ali AU - Hasani A AD - Division of Applied Mechanics, Office of Science and Engineering Laboratories, U.S. Food and Drug Administration, Silver Spring, Maryland, United States of America. FAU - Ibarra, Bryan AU - Ibarra B AD - Division of Applied Mechanics, Office of Science and Engineering Laboratories, U.S. Food and Drug Administration, Silver Spring, Maryland, United States of America. FAU - Snodderly, Kirstie AU - Snodderly K AD - Office of the Chief Scientist, Office of Commissioner, U.S. Food and Drug Administration, Silver Spring, Maryland, United States of America. FAU - Rottach, Dana AU - Rottach D AUID- ORCID: 0000-0003-0459-5980 AD - Office of Product Evaluation and Quality, U.S. Food and Drug Administration, Silver Spring, Maryland, United States of America. FAU - Qian, BiFeng AU - Qian B AD - Office of Product Evaluation and Quality, U.S. Food and Drug Administration, Silver Spring, Maryland, United States of America. FAU - Porter, Daniel AU - Porter D AD - Division of Applied Mechanics, Office of Science and Engineering Laboratories, U.S. Food and Drug Administration, Silver Spring, Maryland, United States of America. FAU - Guha, Suvajyoti AU - Guha S AUID- ORCID: 0000-0002-7622-2721 AD - Division of Applied Mechanics, Office of Science and Engineering Laboratories, U.S. Food and Drug Administration, Silver Spring, Maryland, United States of America. LA - eng SI - figshare/figshare.com/s/52a88ceebdd563ee20aa PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240919 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - *Masks/standards/statistics & numerical data MH - Retrospective Studies MH - *Pediatrics/instrumentation MH - Respiratory Mechanics MH - *Equipment Design/standards MH - Humans MH - Child, Preschool MH - Child MH - Adolescent PMC - PMC11412539 COIS- None to report. EDAT- 2024/09/20 01:18 MHDA- 2024/09/20 01:19 PMCR- 2024/09/19 CRDT- 2024/09/19 13:46 PHST- 2024/04/15 00:00 [received] PHST- 2024/07/14 00:00 [accepted] PHST- 2024/09/20 01:19 [medline] PHST- 2024/09/20 01:18 [pubmed] PHST- 2024/09/19 13:46 [entrez] PHST- 2024/09/19 00:00 [pmc-release] AID - PONE-D-24-14922 [pii] AID - 10.1371/journal.pone.0307879 [doi] PST - epublish SO - PLoS One. 2024 Sep 19;19(9):e0307879. doi: 10.1371/journal.pone.0307879. eCollection 2024. PMID- 39295087 OWN - NLM STAT- MEDLINE DCOM- 20241209 LR - 20260923 IS - 1651-2227 (Electronic) IS - 0803-5253 (Print) IS - 0803-5253 (Linking) VI - 114 IP - 1 DP - 2025 Jan TI - Ultrasound for assessing paediatric body composition and nutritional status: Scoping review and future directions. PG - 14-23 LID - 10.1111/apa.17423 [doi] AB - AIM: This scoping review aims to assess the utility of ultrasound as a prospective tool in measuring body composition and nutritional status in the paediatric population. We provide a comprehensive summary of the existing literature, identify gaps, and propose future research directions. METHODS: We conducted a systematic scoping review following the PRISMA Extension for Scoping Reviews guidelines. This involved screening titles and abstracts of relevant studies, followed by a detailed full-text review and extraction of pertinent data. RESULTS: We identified and synthesised 34 articles. The review revealed that while ultrasound has been used to assess body composition and bone properties in children, significant gaps remain in the literature. These include limited studies on ultrasound performance, insufficient attention to relevant sample characteristics, reliance on manual image measurements, and limited sample diversity. CONCLUSION: Point-of-care ultrasound shows significant promise for assessing paediatric body composition and nutritional status. To validate and enhance its effectiveness, further research is needed. Future studies should include larger and more diverse patient cohorts and conduct longitudinal investigations to evaluate nutritional interventions. Additionally, developing artificial intelligence (AI) for standardising and automating data interpretation will be crucial in improving the accuracy and efficiency of ultrasound assessments. CI - (c) 2024 The Author(s). Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica. FAU - Ranger, Bryan J AU - Ranger BJ AUID- ORCID: 0000-0002-4774-3587 AD - Department of Engineering, Boston College, Chestnut Hill, Massachusetts, USA. AD - William F. Connell School of Nursing, Boston College, Chestnut Hill, Massachusetts, USA. FAU - Lombardi, Allison AU - Lombardi A AD - William F. Connell School of Nursing, Boston College, Chestnut Hill, Massachusetts, USA. FAU - Kwon, Susie AU - Kwon S AD - William F. Connell School of Nursing, Boston College, Chestnut Hill, Massachusetts, USA. FAU - Loeb, Mary AU - Loeb M AD - Department of Engineering, Boston College, Chestnut Hill, Massachusetts, USA. FAU - Cho, Hayoung AU - Cho H AD - Department of Engineering, Boston College, Chestnut Hill, Massachusetts, USA. FAU - He, Keshi AU - He K AD - Department of Engineering, Boston College, Chestnut Hill, Massachusetts, USA. FAU - Wei, Donglai AU - Wei D AD - Department of Computer Science, Boston College, Chestnut Hill, Massachusetts, USA. FAU - Park, Jinhee AU - Park J AD - William F. Connell School of Nursing, Boston College, Chestnut Hill, Massachusetts, USA. LA - eng GR - Boston College/ GR - Google/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Scoping Review DEP - 20240918 PL - Norway TA - Acta Paediatr JT - Acta paediatrica (Oslo, Norway : 1992) JID - 9205968 SB - IM MH - Humans MH - *Body Composition MH - Child MH - *Ultrasonography/methods MH - *Nutritional Status PMC - PMC11627447 OTO - NOTNLM OT - artificial intelligence OT - body composition OT - growth and development OT - machine learning OT - nutrition OT - ultrasound imaging COIS- The authors confirm that there are no relationships or activities related to the submitted manuscript that require disclosure. EDAT- 2024/09/19 06:42 MHDA- 2024/12/09 18:26 PMCR- 2024/12/09 CRDT- 2024/09/19 01:03 PHST- 2024/08/29 00:00 [revised] PHST- 2024/05/30 00:00 [received] PHST- 2024/09/03 00:00 [accepted] PHST- 2024/12/09 18:26 [medline] PHST- 2024/09/19 06:42 [pubmed] PHST- 2024/09/19 01:03 [entrez] PHST- 2024/12/09 00:00 [pmc-release] AID - APA17423 [pii] AID - 10.1111/apa.17423 [doi] PST - ppublish SO - Acta Paediatr. 2025 Jan;114(1):14-23. doi: 10.1111/apa.17423. Epub 2024 Sep 18. PMID- 39294928 OWN - NLM STAT- MEDLINE DCOM- 20250113 LR - 20260904 IS - 1530-0315 (Electronic) IS - 0195-9131 (Linking) VI - 57 IP - 2 DP - 2025 Feb 1 TI - Validity of Wrist-Worn Activity Tracker Heart Rate Detection in Fontan Patients during Exercise. PG - 280-284 LID - 10.1249/MSS.0000000000003567 [doi] AB - PURPOSE: Physical activity and a healthy lifestyle play an essential role in optimizing long-term health in patients with Fontan physiology. Wrist-worn activity trackers may be useful in medically directed exercise programs for patients with Fontan physiology. The objective of this study was to measure the validity of Garmin and Fitbit activity tracker heart rate detection in patients with Fontan circulation when compared with electrocardiogram during cardiopulmonary exercise testing (CPET). METHODS: Forty-seven Fontan patients undergoing CPET for clinical indications were included and wore activity trackers during CPET. Heart rate via the activity tracker was collected at baseline, maximal exercise, and recovery. Patient heart rates, peak V̇O 2 , and peak respiratory exchange ratio were collected using standard CPET protocols and equipment. Heart rate at each time point was compared between the activity trackers and CPET electrocardiogram. RESULTS: Median age of participants was 17.1 yr, 15.1 yr since Fontan completion. Mean percentage of predicted peak V̇O 2 was 56.8%, with a z -score of -3.2, and 61.7% of participants completing a maximal CPET. Baseline mean oxygen saturation was 92.9% and 90.0% at maximal exercise. Activity trackers demonstrated mean absolute percentage error <10% at most time points, comparable with other studies. Demographics, Fontan-associated comorbidities, and echocardiogram findings did not impact the accuracy. CONCLUSIONS: Consumer-oriented wrist-worn activity trackers show promising accuracy for heart rate monitoring in medically directed exercise programs for adolescents and young adults with Fontan physiology. Further validation across different exercise modalities is needed. CI - Copyright (c) 2024 by the American College of Sports Medicine. FAU - Pierick, Alyson R AU - Pierick AR AUID- ORCID: 0000-0001-6875-3621 AD - Division of Pediatric Cardiology, University of Michigan, Ann Arbor, MI. FAU - Burke, Kelly J AU - Burke KJ FAU - Prusi, Megan AU - Prusi M FAU - Largent, Bethany AU - Largent B FAU - Yu, Sunkyung AU - Yu S FAU - Lowery, Ray E AU - Lowery RE FAU - Duimstra, Ashley AU - Duimstra A FAU - Hansen, Jesse E AU - Hansen JE LA - eng PT - Journal Article PT - Validation Study DEP - 20240919 PL - United States TA - Med Sci Sports Exerc JT - Medicine and science in sports and exercise JID - 8005433 SB - IM MH - Humans MH - *Heart Rate/physiology MH - *Fontan Procedure MH - Exercise Test MH - Male MH - Female MH - *Fitness Trackers MH - Adolescent MH - Electrocardiography MH - *Exercise/physiology MH - Oxygen Consumption MH - Wrist MH - Reproducibility of Results MH - Young Adult MH - Child EDAT- 2024/09/19 06:42 MHDA- 2025/01/13 06:16 CRDT- 2024/09/19 00:43 PHST- 2025/01/13 06:16 [medline] PHST- 2024/09/19 06:42 [pubmed] PHST- 2024/09/19 00:43 [entrez] AID - 00005768-990000000-00625 [pii] AID - 10.1249/MSS.0000000000003567 [doi] PST - ppublish SO - Med Sci Sports Exerc. 2025 Feb 1;57(2):280-284. doi: 10.1249/MSS.0000000000003567. Epub 2024 Sep 19. PMID- 39293757 OWN - NLM STAT- MEDLINE DCOM- 20241115 LR - 20251203 IS - 1879-1026 (Electronic) IS - 0048-9697 (Print) IS - 0048-9697 (Linking) VI - 954 DP - 2024 Dec 1 TI - Prenatal exposure to phthalates and childhood wheeze and asthma in the PROGRESS cohort. PG - 176311 LID - S0048-9697(24)06467-2 [pii] LID - 10.1016/j.scitotenv.2024.176311 [doi] AB - INTRODUCTION: Prenatal phthalate exposure may influence lung development and lead to wheezing and asthma in childhood, and these associations may vary by sex. Despite ubiquity of exposure, there is limited epidemiologic data on these associations in Latin America. METHODS: We assessed 593 mother-child dyads enrolled in the Programming Research in Obesity, Growth, Environment, and Social Stressors birth cohort in Mexico City. We quantified 15 phthalate metabolites in 2nd and 3rd trimester maternal urine. Report of ever wheeze, wheeze in the past 12 months (current wheeze) and ever asthma were obtained using a validated survey when children were 4 and 6 years of age. We examined individual associations with modified Poisson models. Mixture effects were assessed using Bayesian Weighted Quantile Sum (BWQS) regression. All models were adjusted for child's sex, maternal age and education at enrollment, and parity. RESULTS: In Poisson models, a doubling of mono (carboxy-isononyl) phthalate (MCNP) during the 2nd trimester was associated with higher risk of wheeze (RR: 1.14, 95 % CI: 1.01, 1.29), and asthma (RR: 1.44, 95 % CI: 1.05, 1.97) at 4 years of age. Higher concentrations of the sum of di-isononyl phthalate metabolites ( summation operatorDiNP) during the 2nd trimester were also associated with asthma at 4 years of age (RR: 1.30, 95 % CI: 1.04, 1.61). Mixture associations of phthalate metabolite concentrations during the 2nd trimester and asthma at 4 years of age were stronger in males (BWQS, OR: 1.94, 95 % CI: 0.90, 4.60; 90 % CrI: 1.04, 3.73) compared to females (BWQS, OR: 1.23, 95 % CI: 0.56, 2.88; 90 % CrI: 0.61, 2.55). Additionally, we observed stronger inverse associations between prenatal phthalate mixtures during the 3rd trimester and current wheeze at 4 and 6 years of age in females (BWQS, OR: 0.54, 90 % CrI: 0.35, 0.82; OR: 0.45, 90 % CrI: 0.22, 0.84) compared to males (BWQS, OR: 0.95, 90 % Cri: 0.68, 1.35; OR: 0.97, 90 % CrI: 0.59, 1.54). CONCLUSIONS: Prenatal phthalate metabolite concentrations were associated with respiratory outcomes in childhood, with some evidence of sex specific effects. Future work investigating phthalate exposure and wheeze trajectories/lung function will be important for understanding how these may predict later disease. CI - Copyright (c) 2024 Elsevier B.V. All rights reserved. FAU - Alcala, Cecilia S AU - Alcala CS AD - Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, USA. Electronic address: cecilia.alcala@mssm.edu. FAU - Lamadrid-Figueroa, Hector AU - Lamadrid-Figueroa H AD - Department of Perinatal Health, Center for Population Health Research, National Institute of Public Health (INSP), Cuernavaca, Morelos, Mexico. FAU - Tamayo-Ortiz, Marcela AU - Tamayo-Ortiz M AD - Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, USA. FAU - Mercado-Garcia, Adriana AU - Mercado-Garcia A AD - Center for Nutrition and Health Research, National Institute of Public Health. Cuernavaca, Morelos, Mexico. FAU - Midya, Vishal AU - Midya V AD - Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, USA. FAU - Just, Allan C AU - Just AC AD - Department of Epidemiology, Brown University School of Public Health, USA. FAU - Foppa-Pedretti, Nicolo AU - Foppa-Pedretti N AD - Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, USA. FAU - Colicino, Elena AU - Colicino E AD - Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, USA. FAU - Tellez-Rojo, Martha M AU - Tellez-Rojo MM AD - Center for Nutrition and Health Research, National Institute of Public Health. Cuernavaca, Morelos, Mexico. FAU - Wright, Robert O AU - Wright RO AD - Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, USA; Kravis Children's Hospital, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, USA; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, USA. FAU - Wright, Rosalind J AU - Wright RJ AD - Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, USA; Kravis Children's Hospital, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, USA; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, USA. FAU - Carroll, Kecia N AU - Carroll KN AD - Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, USA; Kravis Children's Hospital, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, USA. FAU - Rosa, Maria Jose AU - Rosa MJ AD - Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, USA. LA - eng GR - R00 ES027496/ES/NIEHS NIH HHS/United States GR - U24 ES028522/ES/NIEHS NIH HHS/United States GR - R01 ES013744/ES/NIEHS NIH HHS/United States GR - R24 ES028522/ES/NIEHS NIH HHS/United States GR - P30 ES023515/ES/NIEHS NIH HHS/United States GR - R01 ES014930/ES/NIEHS NIH HHS/United States GR - T32 HD049311/HD/NICHD NIH HHS/United States GR - UL1 TR004419/TR/NCATS NIH HHS/United States GR - L40 ES034609/ES/NIEHS NIH HHS/United States GR - K99 ES035894/ES/NIEHS NIH HHS/United States GR - R01 ES033245/ES/NIEHS NIH HHS/United States GR - R01 ES021357/ES/NIEHS NIH HHS/United States PT - Journal Article DEP - 20240916 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 RN - 0 (Phthalic Acids) RN - 0 (Environmental Pollutants) RN - 6O7F7IX66E (phthalic acid) SB - IM MH - Humans MH - *Phthalic Acids MH - *Asthma/epidemiology MH - Female MH - *Prenatal Exposure Delayed Effects/epidemiology MH - Pregnancy MH - *Respiratory Sounds MH - Child, Preschool MH - Male MH - Child MH - *Environmental Pollutants MH - *Maternal Exposure/statistics & numerical data MH - Mexico/epidemiology MH - Cohort Studies MH - Adult PMC - PMC11567787 MID - NIHMS2024570 OTO - NOTNLM OT - Asthma OT - Children's health OT - Endocrine disruptors OT - Mixtures OT - Phthalates OT - Wheeze COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/09/19 00:55 MHDA- 2024/11/16 09:58 PMCR- 2025/12/01 CRDT- 2024/09/18 19:27 PHST- 2024/06/15 00:00 [received] PHST- 2024/09/11 00:00 [revised] PHST- 2024/09/13 00:00 [accepted] PHST- 2024/11/16 09:58 [medline] PHST- 2024/09/19 00:55 [pubmed] PHST- 2024/09/18 19:27 [entrez] PHST- 2025/12/01 00:00 [pmc-release] AID - S0048-9697(24)06467-2 [pii] AID - 10.1016/j.scitotenv.2024.176311 [doi] PST - ppublish SO - Sci Total Environ. 2024 Dec 1;954:176311. doi: 10.1016/j.scitotenv.2024.176311. Epub 2024 Sep 16. PMID- 39293592 OWN - NLM STAT- MEDLINE DCOM- 20241105 LR - 20260718 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 203 DP - 2024 Dec 1 TI - The effects of age on associations between pre-school children's eating behaviour traits and diet quality. PG - 107675 LID - S0195-6663(24)00478-1 [pii] LID - 10.1016/j.appet.2024.107675 [doi] AB - Child eating behaviour traits are associated with several aspects of dietary intake of pre-school children, however the associations between child eating behaviour traits and overall dietary quality in pre-school children has not been examined. Additionally, it is unknown how these relationships vary by age. This study examines the associations between child eating behaviour traits and pre-school children's dietary quality and whether children's age moderates these associations. This study utilises cross-sectional online survey data collected from mothers (n = 1367) of pre-school aged children (2-5 years) from across Australia. The survey included a validated measure of four child eating behaviour traits and a validated measure of diet quality. Multiple linear regression assessed associations between child eating behaviour traits and dietary quality, including interactions between child eating behaviour traits and child age. The average age of the children was 3.3 years, with 50.2% reported as males. Enjoyment of food was positively associated with dietary quality (B coefficient: 2.51, p < 0.001). Food fussiness and satiety responsiveness were inversely associated with dietary quality (B coefficients: 2.59 and -2.25, respectively, p < 0.001), while food responsiveness was not related to diet quality. Child age moderated associations between food fussiness and dietary quality (B coefficient: 0.38, p = 0.025). The difference in dietary quality between lower and higher food fussiness is most pronounced among 5-year-old children. In conclusion, this study demonstrates that it is important for future interventions aiming to improve dietary quality of pre-school children to target children with lower food enjoyment, higher food fussiness or satiety responsiveness as possible ways to improve child dietary quality. Future interventions should also have a particular focus on strategies to reduce food fussiness for older preschoolers. CI - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Burnett, Alissa J AU - Burnett AJ AD - Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia. Electronic address: a.burnett@deakin.edu.au. FAU - Russell, Catherine G AU - Russell CG AD - Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia. FAU - Farrow, Claire AU - Farrow C AD - School of Psychology & Institute of Health and Neurodevelopment, Aston University, Birmingham, United Kingdom. FAU - Spence, Alison C AU - Spence AC AD - Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia. FAU - Worsley, Anthony AU - Worsley A AD - School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia. FAU - Lacy, Kathleen E AU - Lacy KE AD - Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia. LA - eng PT - Journal Article DEP - 20240916 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - Child, Preschool MH - Male MH - Cross-Sectional Studies MH - Australia MH - *Feeding Behavior/psychology MH - *Child Behavior/psychology MH - *Diet/psychology MH - *Food Fussiness MH - Age Factors MH - Diet, Healthy/psychology MH - Satiation MH - Pleasure MH - Surveys and Questionnaires OTO - NOTNLM OT - Appetitive traits OT - Child dietary quality OT - Child eating behaviour traits OT - Pre-school children COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/09/19 00:48 MHDA- 2024/11/06 00:22 CRDT- 2024/09/18 19:23 PHST- 2023/12/07 00:00 [received] PHST- 2024/09/09 00:00 [revised] PHST- 2024/09/09 00:00 [accepted] PHST- 2024/11/06 00:22 [medline] PHST- 2024/09/19 00:48 [pubmed] PHST- 2024/09/18 19:23 [entrez] AID - S0195-6663(24)00478-1 [pii] AID - 10.1016/j.appet.2024.107675 [doi] PST - ppublish SO - Appetite. 2024 Dec 1;203:107675. doi: 10.1016/j.appet.2024.107675. Epub 2024 Sep 16. PMID- 39292072 OWN - NLM STAT- MEDLINE DCOM- 20240918 LR - 20240921 IS - 1806-9282 (Electronic) IS - 0104-4230 (Print) IS - 0104-4230 (Linking) VI - 70 IP - 9 DP - 2024 TI - The relationship between emotional eating disorders and problematic internet use in university students: the mediating role of mukbang behavior. PG - e20240343 LID - S0104-42302024000900611 [pii] LID - 10.1590/1806-9282.20240343 [doi] LID - e20240343 AB - OBJECTIVE: The aim of this study was to investigate the effect of watching mukbang on eating behavior and to emphasize its importance. METHODS: Students from various faculties at universities constitute the sample for this study. A total of 483 individuals participated in the study: 358 (74.1%) women and 125 (25.9%) men. The age range of the sample group varies between 18 and 50 years (Mage=21.62; SD=3.85). In our study, the Emotional Eating Disorder Scale, the Mukbang Addiction Scale, and the Problematic Internet Use Scale were used. Reliability analysis, descriptive statistics, and correlational analysis of the data were carried out using IBM SPSS Statistics 24. RESULTS: There appears to be a positive relationship between emotional eating, mukbang addiction, and problematic internet use. A positive relationship was also found between emotional eating and mukbang addiction. It was found that mukbang addiction had a partial mediator role in the effect of problematic internet use on emotional eating. CONCLUSION: In the relationship between problematic internet use and emotional eating, mukbang addiction has played a mediating role. Therefore, when conducting a study between emotional eating and problematic internet use, it may be useful to examine the frequency of mukbang watching behavior in individuals. It can be crucial to include these people in educational programs to control problematic internet use or the habit of watching mukbang. FAU - Elkin, Nurten AU - Elkin N AUID- ORCID: 0000-0002-9470-2702 AD - Istanbul Gelisim University, Faculty of Health Science - Istanbul, Turkey. FAU - Kutuk, Hasan AU - Kutuk H AUID- ORCID: 0000-0002-8288-4107 AD - Istanbul Gelisim University, Vocational School of Health Services - Istanbul, Turkey. FAU - Gurol, Deniz Misra AU - Gurol DM AUID- ORCID: 0009-0009-9452-2937 AD - Istanbul Gelisim University, Faculty of Economics, Administrative And Social Sciences - Istanbul, Turkey. FAU - Bilgen, Yagmur Dilan AU - Bilgen YD AUID- ORCID: 0009-0005-7992-6125 AD - Istanbul Gelisim University - Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20240913 PL - Brazil TA - Rev Assoc Med Bras (1992) JT - Revista da Associacao Medica Brasileira (1992) JID - 9308586 SB - IM MH - Humans MH - Female MH - Male MH - *Feeding and Eating Disorders/psychology MH - Young Adult MH - *Students/psychology/statistics & numerical data MH - Adolescent MH - Adult MH - Universities MH - *Internet Addiction Disorder/psychology/epidemiology MH - Surveys and Questionnaires MH - *Emotions MH - Middle Aged MH - Behavior, Addictive/psychology/epidemiology MH - Feeding Behavior/psychology MH - Reproducibility of Results MH - Internet/statistics & numerical data PMC - PMC11404997 COIS- Conflicts of interest: the authors declare there is no conflicts of interest. EDAT- 2024/09/18 12:51 MHDA- 2024/09/18 12:52 PMCR- 2024/09/13 CRDT- 2024/09/18 09:23 PHST- 2024/06/09 00:00 [received] PHST- 2024/06/15 00:00 [accepted] PHST- 2024/09/18 12:52 [medline] PHST- 2024/09/18 12:51 [pubmed] PHST- 2024/09/18 09:23 [entrez] PHST- 2024/09/13 00:00 [pmc-release] AID - S0104-42302024000900611 [pii] AID - 10.1590/1806-9282.20240343 [doi] PST - epublish SO - Rev Assoc Med Bras (1992). 2024 Sep 13;70(9):e20240343. doi: 10.1590/1806-9282.20240343. eCollection 2024. PMID- 39290596 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240919 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 12 DP - 2024 TI - A predictive model for stunting among children under the age of three. PG - 1441714 LID - 10.3389/fped.2024.1441714 [doi] LID - 1441714 AB - BACKGROUND: In light of the global effort to eradicate stunting in childhood, the objective of this research endeavor was to assess the prevalence of stunting and associated factors, simultaneously construct and validate a risk prediction model for stunting among children under the age of three in Shenzhen, China. METHODS: Using the stratified random sampling method, we selected 9,581 children under the age of three for research and analysis. The dataset underwent a random allocation into training and validation sets, adhering to a 8:2 split ratio. Within the training set, a combined approach of LASSO regression analysis and binary logistic regression analysis was implemented to identify and select the predictive variables for the model. Subsequently, model construction was conducted in the training set, encompassing model evaluation, visualization, and internal validation procedures. Finally, to assess the model's generalizability, external validation was performed using the validation set. RESULTS: A total of 684 (7.14%) had phenotypes of stunt. Utilizing a combined approach of LASSO regression and logistic regression, key predictors of stunting among children under three years of age were identified, including sex, age in months, mother's education, father's age, birth order, feeding patterns, delivery mode, average daily parent-child reading time, average time spent in child-parent interactions, and average daily outdoor time. These variables were subsequently employed to develop a comprehensive prediction model for childhood stunting. A nomogram model was constructed based on these factors, demonstrating excellent consistency and accuracy. Calibration curves validated the agreement between the nomogram predictions and actual observations. Furthermore, ROC and DCA analyses indicated the strong predictive performance of the nomograms. CONCLUSIONS: The developed model for forecasting stunt risk, which integrates a spectrum of variables. This analytical framework presents actionable intelligence to medical professionals, laying down a foundational framework and a pivot for the conception and execution of preemptive strategies and therapeutic interventions. CI - (c) 2024 Xiong, Hu, Cao, Shang and Niu. FAU - Xiong, Yuxiang AU - Xiong Y AD - Department of Medical Information, School of Public Health, Jilin University, Jilin, China. FAU - Hu, Xuhuai AU - Hu X AD - Research Development, Shenzhen Health Development Research and Data Management Center, Shenzhen, Guangdong, China. FAU - Cao, Jindan AU - Cao J AD - Department of Medical Information, School of Public Health, Jilin University, Jilin, China. FAU - Shang, Li AU - Shang L AD - Research Development, Shenzhen Health Development Research and Data Management Center, Shenzhen, Guangdong, China. FAU - Niu, Ben AU - Niu B AD - Department of Software Technology, School of Software Engineering, Shenzhen Institute of Information Technology, Shenzhen, Guangdong, China. AD - Department of Management Science, College of Management, Shenzhen University, Shenzhen, Guangdong, China. LA - eng PT - Journal Article DEP - 20240903 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC11405321 OTO - NOTNLM OT - LASSO OT - ages and stages questionnaires OT - clinical prediction models OT - nomogram OT - stunting COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/09/18 06:42 MHDA- 2024/09/18 06:43 PMCR- 2024/09/03 CRDT- 2024/09/18 04:30 PHST- 2024/05/31 00:00 [received] PHST- 2024/08/16 00:00 [accepted] PHST- 2024/09/18 06:43 [medline] PHST- 2024/09/18 06:42 [pubmed] PHST- 2024/09/18 04:30 [entrez] PHST- 2024/09/03 00:00 [pmc-release] AID - 10.3389/fped.2024.1441714 [doi] PST - epublish SO - Front Pediatr. 2024 Sep 3;12:1441714. doi: 10.3389/fped.2024.1441714. eCollection 2024. PMID- 39290316 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240919 IS - 2475-2991 (Electronic) IS - 2475-2991 (Linking) VI - 8 IP - 9 DP - 2024 Sep TI - Cross-National Study on the Convergent, Discriminant, and Concurrent Validity of the "Body Size Perception" Item in the Health Behaviour in School-aged Children Survey. PG - 104445 LID - 10.1016/j.cdnut.2024.104445 [doi] LID - 104445 AB - BACKGROUND: Despite its significant usefulness in adolescent health studies, the single-item "body size perception" question, developed within the Health Behaviour in School-aged Children (HBSC) survey, has yet to undergo multidimensional validation. OBJECTIVES: To assess the convergent, divergent and concurrent validity of the HBSC body size perception question among adolescents. METHODS: The single-item HBSC body size perception question is as follows: "Do you think your body is...?," with answers ranging from "much too thin" to "much too fat." Fifteen-year-old participants included in the analysis were 72,086 from 45 HBSC countries in 2017/18 (concurrent validity), and 595, 127, and 615 in 2021/22 in French-speaking Belgium, Ireland, and Poland, respectively. The convergent, divergent, and concurrent validity was assessed with body dissatisfaction, social desirability, and selfesteem, respectively. The concurrent validity was also examined with body mass index (BMI) from the 2017/18 HBSC data. All analyses were sex-stratified. RESULTS: Cohen's Kappa values were 0.67 [confidence interval (CI): 95%: 0.62, 0.72] and 0.64 (0.59, 0.69) for boys and girls, respectively, in all 3 countries together. Body size perception was associated with social desirability, selfesteem, and BMI, with a stronger association in girls than that in boys. For instance, girls with higher social desirability were less likely to perceive themselves as "too thin" [Relative Risk Ratio (RRR) = 0.78 (0.69, 0.89)] rather than as the "right size." Boys with higher selfesteem were less likely to perceive themselves as "too fat" [0.93 (0.90, 0.97)] rather than the "right size." Girls with underweight were less likely to perceive themselves as "too fat" [0.38 (0.34, 043)] rather than "right size" and girls with overweight/obesity were more likely to perceive themselves as such [8.19 (7.49, 8.95)]. CONCLUSIONS: The single-item HBSC body size perception question demonstrated good convergent, divergent, and concurrent validity. It reflects adolescents' own perception of body size, possibly influenced by societal norms and ideals. CI - (c) 2024 The Author(s). FAU - Rouche, Manon AU - Rouche M AD - Research Center in Epidemiology, Biostatistics and Clinical Trials, School of Public Health, Universite libre de Bruxelles, Brussels, Belgium. AD - Department of Epidemiology and Data Science, Amsterdam UMC Location Vrije Universiteit, Amsterdam, the Netherlands. FAU - Lebacq, Theresa AU - Lebacq T AD - Research Center in Epidemiology, Biostatistics and Clinical Trials, School of Public Health, Universite libre de Bruxelles, Brussels, Belgium. AD - Department of Epidemiology and Public Health, Sciensano, Brussels, Belgium. FAU - Dzielska, Anna AU - Dzielska A AD - Department of Child and Adolescent Health, Institute of Mother and Child, Warsaw, Poland. FAU - Kelly, Colette AU - Kelly C AD - Health Promotion Research Centre, School of Health Sciences, University of Galway, Galway, Ireland. FAU - Gabhainn, Saoirse Nic AU - Gabhainn SN AD - Health Promotion Research Centre, School of Health Sciences, University of Galway, Galway, Ireland. FAU - Mertens, Caroline AU - Mertens C AD - Research Center in Epidemiology, Biostatistics and Clinical Trials, School of Public Health, Universite libre de Bruxelles, Brussels, Belgium. FAU - Castetbon, Katia AU - Castetbon K AD - Research Center in Epidemiology, Biostatistics and Clinical Trials, School of Public Health, Universite libre de Bruxelles, Brussels, Belgium. LA - eng PT - Journal Article DEP - 20240818 PL - United States TA - Curr Dev Nutr JT - Current developments in nutrition JID - 101717957 PMC - PMC11406042 OTO - NOTNLM OT - HBSC OT - adolescents OT - body image OT - body size perception OT - validation EDAT- 2024/09/18 06:42 MHDA- 2024/09/18 06:43 PMCR- 2024/08/18 CRDT- 2024/09/18 04:25 PHST- 2024/06/10 00:00 [received] PHST- 2024/08/14 00:00 [revised] PHST- 2024/08/16 00:00 [accepted] PHST- 2024/09/18 06:43 [medline] PHST- 2024/09/18 06:42 [pubmed] PHST- 2024/09/18 04:25 [entrez] PHST- 2024/08/18 00:00 [pmc-release] AID - S2475-2991(24)02379-5 [pii] AID - 104445 [pii] AID - 10.1016/j.cdnut.2024.104445 [doi] PST - epublish SO - Curr Dev Nutr. 2024 Aug 18;8(9):104445. doi: 10.1016/j.cdnut.2024.104445. eCollection 2024 Sep. PMID- 39290052 OWN - NLM STAT- MEDLINE DCOM- 20241108 LR - 20250828 IS - 1365-277X (Electronic) IS - 0952-3871 (Linking) VI - 37 IP - 6 DP - 2024 Dec TI - Food-related quality of life driven by hypervigilance and anxiety around eating in organic gastrointestinal conditions. PG - 1505-1515 LID - 10.1111/jhn.13358 [doi] AB - BACKGROUND: Food-related quality of life (FRQoL) measures the impact of diet, eating behaviours and food-related anxiety on quality of life. Patients often view food and eating as central to symptom management. This is the first study to examine FRQoL in patients with inflammatory bowel disease, celiac sprue, achalasia and eosinophilic oesophagitis. METHODS: A total of 289 adults aged >/=18 years completed self-report measures evaluating the use of dietary treatment, FRQoL and other psychosocial outcomes. Principal component factor analysis evaluated potential subscales within the Food-Related Quality of Life Scale (FRQoL-29), to date validated only with a total score. Univariate analyses investigated differences in FRQoL based on diagnosis, whereas correlations and hierarchical regression identified relationships between FRQoL and psychosocial outcomes. RESULTS: Factor analysis revealed four subscales within the FRQoL-29, with hypervigilance around eating being the primary driver in total score. Patients reported substantial impacts of FRQoL, with those not using diet therapy scoring significantly higher for FRQoL than those on a diet with and without the support of a registered dietitian (RD). Both social (r = 0.41, p < 0.001) and physical (r = 0.31, p < 0.001) domains of health-related quality of life were higher in patients with greater FRQoL. CONCLUSION: FRQoL is significantly degraded in patients with organic gastrointestinal illness diseases, and hypervigilance around food appears to contribute most to this. Use of dietary treatment and meeting with an RD were associated with lower FRQoL, though it is unclear if patients sought RD assistance before FRQoL declined. Future studies on the relationship between dietary treatment, RD support and FRQoL are warranted. CI - (c) 2024 The Author(s). Journal of Human Nutrition and Dietetics published by John Wiley & Sons Ltd on behalf of British Dietetic Association. FAU - Simons, Madison AU - Simons M AUID- ORCID: 0000-0002-5042-2725 AD - Northwestern University Feinberg School of Medicine, Division of Gastroenterology and Hepatology, Chicago, Illinois, USA. FAU - McGarva, Josie AU - McGarva J AD - Northwestern University Feinberg School of Medicine, Division of Gastroenterology and Hepatology, Chicago, Illinois, USA. FAU - Doerfler, Bethany AU - Doerfler B AD - Northwestern University Feinberg School of Medicine, Division of Gastroenterology and Hepatology, Chicago, Illinois, USA. FAU - Tomasino, Kathryn AU - Tomasino K AD - Northwestern University Feinberg School of Medicine, Division of Gastroenterology and Hepatology, Chicago, Illinois, USA. FAU - Pandit, Anjali AU - Pandit A AD - Northwestern University Feinberg School of Medicine, Division of Gastroenterology and Hepatology, Chicago, Illinois, USA. FAU - Lembo, Anthony AU - Lembo A AD - Cleveland Clinic Foundation, Cleveland, Ohio, USA. FAU - Taft, Tiffany AU - Taft T AD - Northwestern University Feinberg School of Medicine, Division of Gastroenterology and Hepatology, Chicago, Illinois, USA. LA - eng GR - None/ GR - P01 DK117824/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20240917 PL - England TA - J Hum Nutr Diet JT - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JID - 8904840 SB - IM MH - Humans MH - *Quality of Life/psychology MH - Male MH - Female MH - Adult MH - Middle Aged MH - *Anxiety/psychology MH - *Gastrointestinal Diseases/psychology/complications/etiology MH - Surveys and Questionnaires MH - Aged MH - Feeding Behavior/psychology MH - Young Adult MH - Self Report MH - Diet/psychology MH - Eating/psychology MH - Adolescent OTO - NOTNLM OT - diet OT - eating behaviour OT - gastrointestinal OT - hypervigilance OT - quality of life EDAT- 2024/09/18 06:42 MHDA- 2024/11/13 13:56 CRDT- 2024/09/18 02:53 PHST- 2024/07/22 00:00 [revised] PHST- 2024/03/20 00:00 [received] PHST- 2024/07/25 00:00 [accepted] PHST- 2024/11/13 13:56 [medline] PHST- 2024/09/18 06:42 [pubmed] PHST- 2024/09/18 02:53 [entrez] AID - 10.1111/jhn.13358 [doi] PST - ppublish SO - J Hum Nutr Diet. 2024 Dec;37(6):1505-1515. doi: 10.1111/jhn.13358. Epub 2024 Sep 17. PMID- 39289733 OWN - NLM STAT- MEDLINE DCOM- 20240918 LR - 20240920 IS - 1756-0500 (Electronic) IS - 1756-0500 (Linking) VI - 17 IP - 1 DP - 2024 Sep 18 TI - The association of food insecurity with non-alcoholic fatty liver disease (NAFLD) in a sample of Iranian adults: a path analysis of a cross-sectional survey. PG - 272 LID - 10.1186/s13104-024-06923-4 [doi] LID - 272 AB - OBJECTIVES: The present study aims to examine the hypothetical model of the relationship between food insecurity and Non-alcoholic fatty liver disease (NAFLD) in a sample of Iranian adults. METHODS: In this cross-sectional study, 275 subjects (18-70 years old) who met the inclusion criteria were recruited. Fatty liver was diagnosed by abdominal ultrasonography, and eligible patients underwent liver fibro scan assessment to determine fibrosis and steatosis. Food insecurity was assessed using the validated six-item Short Questionnaire of Household Food Security Scale (SQHFSS). Data were analyzed using SPSS 24.0 and IBM SPSS Amos 24.0. RESULTS: Among 275 subjects (44.37 +/- 11.67 years old, 51.6% male) included in the analysis, 23.6% were food insecure. Food insecurity, general and abdominal obesity were associated with an increased risk of NAFLD, even after multiple adjustments (OR: 2.95, 95% CI: 1.02, 8.57; OR: 3.27, 95% CI: 1.50, 7.11; and OR: 3.81, 95% CI: 1.55, 9.32, respectively). According to the primary hypothesis, food insecurity and NAFLD were fitted into a model (chi(2)/df = 1.36, GFI = 0.982, AGFI = 0.952, CFI = 0.954, IFI = 0.959, SRMR = 0.040, RMSEA = 0.037); accordingly, food insecurity and obesity (general and abdominal) directly affected NAFLD (beta = 0.12, P = 0.03; beta = 0.13, P = 0.02; beta = 0.31, P < 0.001, respectively). CONCLUSION: Food insecurity was a predictor of, and directly associated with, NAFLD. Social determinants should be considered in the pathogenesis of NAFLD, although the possible underlying biological mechanisms in this association are yet to be determined. CI - (c) 2024. The Author(s). FAU - Sohrabi, Masoudreza AU - Sohrabi M AD - Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran. FAU - Amirkalali, Bahareh AU - Amirkalali B AD - Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran. FAU - Gholami, Ali AU - Gholami A AD - Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran. AD - Department of Epidemiology & Biostatistics, School of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran. FAU - Hajjar, Melika AU - Hajjar M AD - Student Research Committee (National Nutrition and Food Technology Research Institute, Department of Community Nutrition, School of Nutrition Sciences and Food Technology), Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Sohrabi, Melika AU - Sohrabi M AD - Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran. FAU - NasiriToosi, Mohsen AU - NasiriToosi M AD - Liver Transplantation research center, Tehran University of medical sciences, Tehran, Iran. FAU - Keyvani, Hossein AU - Keyvani H AD - Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran. FAU - Zamani, Farhad AU - Zamani F AD - Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran. farhad@gmail.com. FAU - Doustmohammadian, Azam AU - Doustmohammadian A AUID- ORCID: 0000-0001-6249-2520 AD - Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran. mohammadian.az@iums.ac.ir. LA - eng PT - Journal Article DEP - 20240918 PL - England TA - BMC Res Notes JT - BMC research notes JID - 101462768 SB - IM MH - Humans MH - *Non-alcoholic Fatty Liver Disease/epidemiology MH - Iran/epidemiology MH - Male MH - Adult MH - Cross-Sectional Studies MH - Middle Aged MH - Female MH - *Food Insecurity MH - Young Adult MH - Adolescent MH - Aged MH - Obesity, Abdominal/epidemiology/complications MH - Risk Factors PMC - PMC11409597 OTO - NOTNLM OT - Food insecurity OT - Non-alcoholic fatty liver disease OT - Obesity OT - Path analysis OT - Waist circumference COIS- The authors declare no competing interests. EDAT- 2024/09/18 00:51 MHDA- 2024/09/18 06:42 PMCR- 2024/09/18 CRDT- 2024/09/17 23:48 PHST- 2023/07/06 00:00 [received] PHST- 2024/08/28 00:00 [accepted] PHST- 2024/09/18 06:42 [medline] PHST- 2024/09/18 00:51 [pubmed] PHST- 2024/09/17 23:48 [entrez] PHST- 2024/09/18 00:00 [pmc-release] AID - 10.1186/s13104-024-06923-4 [pii] AID - 6923 [pii] AID - 10.1186/s13104-024-06923-4 [doi] PST - epublish SO - BMC Res Notes. 2024 Sep 18;17(1):272. doi: 10.1186/s13104-024-06923-4. PMID- 39288436 OWN - NLM STAT- MEDLINE DCOM- 20240917 LR - 20250203 IS - 1529-7535 (Print) IS - 1947-3893 (Electronic) IS - 1529-7535 (Linking) VI - 25 IP - 9 DP - 2024 Sep 1 TI - Accuracy and Interpretation of Transcutaneous Carbon Dioxide Monitoring in Critically Ill Children. PG - e372-e379 LID - 10.1097/PCC.0000000000003564 [doi] AB - OBJECTIVES: Transcutaneous carbon dioxide (Tc co2 ) monitoring can noninvasively assess ventilation by estimating carbon dioxide ( CO2 ) levels in the blood. We aimed to evaluate the accuracy of Tc co2 monitoring in critically ill children by comparing it to the partial pressure of arterial carbon dioxide (Pa co2 ). In addition, we sought to determine the variation between Tc co2 and Pa co2 acceptable to clinicians to modify patient care and to determine which patient-level factors may affect the accuracy of Tc co2 measurements. DESIGN: Retrospective observational cohort study. SETTING: Single, quaternary care PICU from July 1, 2012, to August 1, 2020. PATIENTS: Included participants were admitted to the PICU and received noninvasive ventilation support (i.e., continuous or bilevel positive airway pressure), conventional mechanical ventilation, or high-frequency oscillatory or percussive ventilation with Tc co2 measurements obtained within 15 minutes of Pa co2 measurement. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Three thousand four hundred seven paired arterial blood gas and Tc co2 measurements were obtained from 264 patients. Bland-Altman analysis revealed a bias of -4.4 mm Hg (95% CI, -27 to 18.3 mm Hg) for Tc co2 levels against Pa co2 levels on the first measurement pair for each patient, which fell within the acceptable range of +/-5 mm Hg stated by surveyed clinicians, albeit with wide limits of agreement. The sensitivity and specificity of Tc co2 to diagnose hypercarbia were 93% and 71%, respectively. Vasoactive-Infusion Score (VIS), age, and self-identified Black/African American race confounded the relationship between Tc co2 with Pa co2 but percent fluid overload, weight-for-age, probe location, and severity of illness were not significantly associated with Tc co2 accuracy. CONCLUSIONS: Tc co2 monitoring may be a useful adjunct to monitor ventilation in children with respiratory failure, but providers must be aware of the limitations to its accuracy. CI - Copyright (c) 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. FAU - Setar, Leah AU - Setar L AD - Ann and Robert H. Lurie Children's Hospital, Chicago, IL. AD - Division of Pediatrics, Northwestern McGaw Medical Center, Chicago, IL. FAU - Lee, Jessica G AU - Lee JG AD - Ann and Robert H. Lurie Children's Hospital, Chicago, IL. AD - Division of Pediatrics, Northwestern McGaw Medical Center, Chicago, IL. FAU - Sanchez-Pinto, L Nelson AU - Sanchez-Pinto LN AD - Ann and Robert H. Lurie Children's Hospital, Chicago, IL. AD - Division of Pediatrics, Northwestern McGaw Medical Center, Chicago, IL. FAU - Coates, Bria M AU - Coates BM AD - Ann and Robert H. Lurie Children's Hospital, Chicago, IL. AD - Division of Pediatrics, Northwestern McGaw Medical Center, Chicago, IL. LA - eng GR - R01 HL168672/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Observational Study DEP - 20240627 PL - United States TA - Pediatr Crit Care Med JT - Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies JID - 100954653 RN - 142M471B3J (Carbon Dioxide) SB - IM MH - Humans MH - Retrospective Studies MH - *Blood Gas Monitoring, Transcutaneous/methods MH - *Critical Illness MH - Male MH - Female MH - Child, Preschool MH - Child MH - Infant MH - *Carbon Dioxide/blood/analysis MH - *Intensive Care Units, Pediatric MH - Adolescent MH - Respiration, Artificial PMC - PMC11368163 COIS- Dr. Coates received support for article research from The Doris Duke Foundation and The American Lung Association. Dr. Coates' institution received funding from the Walder Foundation, the Doris Duke Foundation, the National Heart, Lung, and Blood Institute (R01 HL168672), and the American Lung Association; she received funding from Sobi, Triplett Woolf Garretson, LLC, and the Centers for Disease Control and Prevention; and she received support for article research from the Walder Foundation and the Doris Duke Foundation. The remaining authors have disclosed that they do not have any potential conflicts of interest. EDAT- 2024/09/17 23:43 MHDA- 2024/09/17 23:44 PMCR- 2024/09/02 CRDT- 2024/09/17 17:19 PHST- 2024/09/17 23:44 [medline] PHST- 2024/09/17 23:43 [pubmed] PHST- 2024/09/17 17:19 [entrez] PHST- 2024/09/02 00:00 [pmc-release] AID - 00130478-202409000-00016 [pii] AID - PCCM-D-24-00009 [pii] AID - 10.1097/PCC.0000000000003564 [doi] PST - ppublish SO - Pediatr Crit Care Med. 2024 Sep 1;25(9):e372-e379. doi: 10.1097/PCC.0000000000003564. Epub 2024 Jun 27. PMID- 39287603 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250602 IS - 2561-6722 (Electronic) IS - 2561-6722 (Linking) VI - 7 DP - 2024 Sep 17 TI - Development and Delivery of an Integrated Digital Health Care Approach for Children With Juvenile Idiopathic Arthritis: Usability Study. PG - e56816 LID - 10.2196/56816 [doi] LID - e56816 AB - BACKGROUND: Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disorder with no cure. Most children are prescribed several medications aimed at controlling disease activity, managing symptoms, and reducing pain. Physical activity is also encouraged to retain musculoskeletal function. The primary determinants of treatment success are maintaining long-term adherence, ongoing monitoring by a pediatric rheumatologist, and involvement of an interdisciplinary team. To support these goals, a new digital intervention was developed, InteractiveClinics, which aimed to prompt children to take their medications, report pain levels, and increase their physical activity. OBJECTIVE: This study aims to evaluate the usability of InteractiveClinics among children with JIA. METHODS: As part of this pediatric cross-sectional study, 12 children were asked to wear a smartwatch for 2 weeks, which was synchronized to the InteractiveClinics phone app and web-based platform. Personalized notifications were sent daily to the watch and phone, to prompt and record medication adherence and pain level assessment. Physical activity was automatically recorded by the watch. At the end of the study, all children and parents completed a postintervention survey. Written comments were also encouraged to gain further feedback. Descriptive statistics were used to summarize the survey results, and all qualitative data underwent thematic analysis. RESULTS: Twelve children aged 10 to 18 years (mean 14.2, SD 3.1 years; female: n=8, 66.7%) and 1 parent for each child (n=12; female: n=8, 66.7%) were enrolled in the study. Based on the highest and lowest agreement areas of the survey, most children and parents liked the smartwatch and web-based platform; they found it easy to learn and simple to use. They were also satisfied with the pain and physical activity module. However, usability and acceptability barriers that hindered uptake were identified in the phone app and medication module. Children required a unique in-app experience, and their suggestive improvements included more personalization within the app; simplification by removing all links not relevant to antirheumatic medications; flexibility in response times; improved conferment through gamification; additional comment fields for the input of more data, such as medication side effects or pain-related symptoms; more detailed graphical illustrations of the physical activity module, including a breakdown of metrics; and importantly, interconnections between modules, because medication adherence, pain levels, and physical activity can each influence the other. They were, overall, improving usefulness for children and parents. CONCLUSIONS: The usability of InteractiveClinics was positive. Children and parents liked the watch and web-based platform and were satisfied with the pain and physical activity module. However, children wanted a unique in-app experience through more personalization, simplification, flexibility, conferment, comment fields, graphical illustrations, a breakdown of metrics, and interconnections. Certainly, inclusions are needed to promote user adoption and advancement of new validated digital health interventions in pediatric rheumatology, to support the delivery of integrated care. CI - (c) Sonia Butler, Dean Sculley, Derek Santos, Xavier Girones, Davinder Singh-Grewal, Andrea Coda. Originally published in JMIR Pediatrics and Parenting (https://pediatrics.jmir.org). FAU - Butler, Sonia AU - Butler S AUID- ORCID: 0000-0002-5492-7966 AD - School of Bioscience and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Ourimbah, Australia. FAU - Sculley, Dean AU - Sculley D AUID- ORCID: 0000-0003-3972-8309 AD - School of Bioscience and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Ourimbah, Australia. FAU - Santos, Derek AU - Santos D AUID- ORCID: 0000-0001-9936-715X AD - School of Health Sciences, Queen Margaret University, Edinburgh, United Kingdom. FAU - Girones, Xavier AU - Girones X AUID- ORCID: 0000-0002-2329-5927 AD - Department of Research and Universities, Generalitat de Catalunya, Government of Catalonia, Barcelona, Spain. FAU - Singh-Grewal, Davinder AU - Singh-Grewal D AUID- ORCID: 0000-0001-7306-3713 AD - Department of Rheumatology, Sydney Children's Hospitals Network, Randwick and Westmead, Sydney, Australia. AD - Discipline of Child and Adolescent Health, University of Sydney, Sydney, Australia. AD - School of Women's and Children's Health, University of New South Wales, Sydney, Australia. AD - Department of Rheumatology, John Hunter Children's Hospital, Newcastle, Australia. FAU - Coda, Andrea AU - Coda A AUID- ORCID: 0000-0003-0427-6672 AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Ourimbah, Australia. AD - Equity in Health and Wellbeing Research Program, Hunter Medical Research Institute, Newcastle, Australia. LA - eng PT - Journal Article DEP - 20240917 PL - Canada TA - JMIR Pediatr Parent JT - JMIR pediatrics and parenting JID - 101727244 PMC - PMC11421306 OTO - NOTNLM OT - child OT - children OT - chronic inflammatory disorder OT - development OT - gamification OT - integrated care OT - juvenile idiopathic arthritis OT - medication OT - medication adherence OT - modules OT - pain OT - phone app OT - physical activity OT - smart watch OT - support OT - survey OT - thematic analysis OT - usability OT - usability study OT - web-based platform COIS- Conflicts of Interest: None declared. EDAT- 2024/09/17 21:47 MHDA- 2024/09/17 21:48 PMCR- 2024/09/17 CRDT- 2024/09/17 10:33 PHST- 2024/02/18 00:00 [received] PHST- 2024/04/25 00:00 [revised] PHST- 2024/05/22 00:00 [accepted] PHST- 2024/09/17 21:48 [medline] PHST- 2024/09/17 21:47 [pubmed] PHST- 2024/09/17 10:33 [entrez] PHST- 2024/09/17 00:00 [pmc-release] AID - v7i1e56816 [pii] AID - 56816 [pii] AID - 10.2196/56816 [doi] PST - epublish SO - JMIR Pediatr Parent. 2024 Sep 17;7:e56816. doi: 10.2196/56816. PMID- 39282918 OWN - NLM STAT- MEDLINE DCOM- 20240916 LR - 20240916 IS - 1399-3038 (Electronic) IS - 0905-6157 (Linking) VI - 35 IP - 9 DP - 2024 Sep TI - Early-pregnancy BMI, maternal gestational weight gain, and asthma and allergic diseases in children. PG - e14240 LID - 10.1111/pai.14240 [doi] AB - BACKGROUND: Association of early pregnancy body mass index (BMI) and maternal gestational weight gain (GWG), and asthma and allergic disease in children is unclear. METHODS: We analyzed data from 3176 mother-child pairs in a prospective birth cohort study. Maternal anthropometric measurements in the first and last antenatal clinic visits were obtained through post-delivery questionnaires to calculate early pregnancy BMI and maternal GWG. Asthma and allergic diseases in children by the age of 5 years was assessed using a validated questionnaire. Furthermore, serum samples were analyzed for IgE antibodies to eight allergens. We applied Cox proportional hazards and logistic regression analyses to estimate the association of early pregnancy BMI and maternal GWG (as continuous variables and categorized into quarters), and asthma, atopic eczema, atopic sensitization, and allergic rhinitis in children. RESULTS: Neither early pregnancy BMI nor maternal GWG was associated with asthma and allergic disease in children when analyzed as continuous variables. However, compared to the first quarter of GWG (a rate <0.32 kg/week), mothers in the third quarter (rate 0.42-0.52 kg/week) had children with significantly higher odds of developing atopic eczema (adjusted OR 1.49, 95% CI [1.13-1.96]) by 5 years of age. CONCLUSION: Association of early pregnancy BMI and maternal GWG, and asthma and allergic disease in children, is inconsistent. High maternal GWG may be associated with increased odds of atopic eczema. CI - (c) 2024 The Author(s). Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. FAU - Ojwang', Vincent AU - Ojwang' V AUID- ORCID: 0000-0002-7797-030X AD - Faculty of Social Sciences, Health Sciences Unit, Tampere University, Tampere, Finland. AD - SEVIN's Institute for Health Research, Kisumu, Kenya. AD - Department of Community Health and Behavioral Sciences, School of Medicine, Masinde Muliro University of Science and Technology, Kakamega, Kenya. FAU - Nwaru, Bright I AU - Nwaru BI AUID- ORCID: 0000-0002-2876-6089 AD - Faculty of Social Sciences, Health Sciences Unit, Tampere University, Tampere, Finland. AD - Krefting Research Centre, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden. AD - Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden. FAU - Hanna-Mari, Takkinen AU - Hanna-Mari T AD - Faculty of Social Sciences, Health Sciences Unit, Tampere University, Tampere, Finland. AD - Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland. AD - Center for Child Health Research, Tampere University and Tampere University Hospital, Tampere, Finland. FAU - Heli, Tapanainen AU - Heli T AD - Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland. FAU - Kaila, Minna AU - Kaila M AUID- ORCID: 0000-0002-9645-4925 AD - Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland. AD - Department of Pediatrics, Tampere University Hospital, Tampere, Finland. AD - Public Health Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. FAU - Ahonen, Suvi AU - Ahonen S AD - Faculty of Social Sciences, Health Sciences Unit, Tampere University, Tampere, Finland. AD - Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland. FAU - Niemela, Onni AU - Niemela O AD - Department of Laboratory Medicine and Medical Research Unit, Seinajoki Central Hospital and University of Tampere, Tampere, Finland. FAU - Haapala, Anna-Maija AU - Haapala AM AD - Fimlab laboratories, Pirkanmaa Hospital District, Tampere, Finland. FAU - Ilonen, Jorma AU - Ilonen J AD - Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland. AD - Department of Clinical Microbiology, Turku University Hospital, Turku, Finland. FAU - Toppari, Jorma AU - Toppari J AD - Institute of Biomedicine, Research Centre of Integrative Physiology and Pharmacology, University of Turku, Turku, Finland. AD - Department of Pediatrics, Turku University Hospital, Turku, Finland. FAU - Hyoty, Heikki AU - Hyoty H AD - Department of Laboratory Medicine and Medical Research Unit, Seinajoki Central Hospital and University of Tampere, Tampere, Finland. AD - Department of Virology, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. FAU - Veijola, Riitta AU - Veijola R AD - Department of Pediatrics, PEDEGO Research Unit, Medical Research Centre, Oulu University, Hospital and University of Oulu, Oulu, Finland. FAU - Knip, Mikael AU - Knip M AUID- ORCID: 0000-0003-0474-0033 AD - Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland. AD - Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland. FAU - Virtanen, Suvi M AU - Virtanen SM AD - Faculty of Social Sciences, Health Sciences Unit, Tampere University, Tampere, Finland. AD - Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden. AD - Center for Child Health Research, Tampere University and Tampere University Hospital, Tampere, Finland. LA - eng GR - Research Council of Finland/ GR - European Union Biomed 2 Program/ GR - Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital/ GR - Competitive Research Funding of the Turku and Oulu University Hospitals/ GR - European Foundation for the Study of Diabetes/ GR - Yrjo Jahnssonin Saatio/ GR - Juho Vainion Saatio/ GR - Tampereen Tuberkuloosisaatio/ GR - Foundation for Pediatric Research/ GR - Prevaller Consortium/ GR - European Union Horizon 2020 Research and Innovation Programme/ GR - Novo Nordisk Foundation/ GR - Juvenile Diabetes Research Foundation/ PT - Journal Article PL - England TA - Pediatr Allergy Immunol JT - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JID - 9106718 RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Humans MH - Pregnancy MH - Female MH - *Body Mass Index MH - *Asthma/epidemiology/immunology MH - *Gestational Weight Gain MH - Child, Preschool MH - Male MH - Prospective Studies MH - *Hypersensitivity/epidemiology/immunology MH - Adult MH - Immunoglobulin E/blood MH - Infant MH - Dermatitis, Atopic/epidemiology/immunology MH - Prenatal Exposure Delayed Effects/epidemiology/immunology MH - Surveys and Questionnaires MH - Cohort Studies MH - Birth Cohort MH - Infant, Newborn OTO - NOTNLM OT - BMI OT - allergic rhinitis OT - asthma OT - atopic eczema OT - atopic sensitization OT - children OT - early pregnancy OT - gestational weight gain EDAT- 2024/09/17 10:45 MHDA- 2024/09/17 10:46 CRDT- 2024/09/16 07:43 PHST- 2024/08/27 00:00 [revised] PHST- 2024/06/04 00:00 [received] PHST- 2024/08/29 00:00 [accepted] PHST- 2024/09/17 10:46 [medline] PHST- 2024/09/17 10:45 [pubmed] PHST- 2024/09/16 07:43 [entrez] AID - 10.1111/pai.14240 [doi] PST - ppublish SO - Pediatr Allergy Immunol. 2024 Sep;35(9):e14240. doi: 10.1111/pai.14240. PMID- 39280521 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240918 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 16 IP - 8 DP - 2024 Aug TI - Validity and Reliability of a Questionnaire Assessing Changes in Dietary Behaviors Among School Children Amid the COVID-19 Pandemic in Jordan. PG - e66980 LID - 10.7759/cureus.66980 [doi] LID - e66980 AB - OBJECTIVE: This study aimed to develop and validate a questionnaire to assess changes in dietary behaviors among school children in Jordan during the COVID-19 pandemic. METHODS: A cross-sectional study used a convenience sample of 253 school-aged children from public schools across Jordan. The dietary and lifestyle behavior inventory (DLBI) was developed, incorporating cultural and regional dietary preferences. The questionnaire's validity and reliability were assessed using the content validity index (CVI) and Cronbach's alpha for internal consistency. Exploratory factor analysis (EFA) was conducted to evaluate the underlying factor structure. RESULTS: The DLBI demonstrated excellent content validity with a scale content validity index (S-CVI) of 0.997 and a high level of agreement among expert reviewers (total agreement = 116). Reliability analysis showed high internal consistency for dietary behavior scales, with Cronbach's alpha values exceeding 0.9 for fruit (0.869) and vegetable (0.916) consumption scales. Factor analysis revealed strong associations between dietary behavior variables, with factor loadings ranging from 0.688 to 0.889. The study identified significant reductions in physical activity levels among children, with an average Cronbach's alpha of 0.835 for physical activity-related items. The average time to complete the questionnaire was 15 minutes (SD = 5 minutes), with a completion rate of 45.6%. CONCLUSIONS: The validated DLBI is a robust tool for assessing changes in dietary behaviors among school-aged children in Jordan during the COVID-19 pandemic. The findings highlight significant dietary patterns and physical activity shifts, emphasizing the need for targeted nutritional interventions. CI - Copyright (c) 2024, Alarsan et al. FAU - Alarsan, Sami F AU - Alarsan SF AD - Epidemiology and Public Health, National University of Malaysia, Selangor, MYS. FAU - Mohd Saat, Nur Zakiah AU - Mohd Saat NZ AD - Health Education, Researchers Center for Community Health Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, MYS. FAU - Abd Talib, Ruzita AU - Abd Talib R AD - Nutrition, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, MYS. FAU - Saadeh, Nesreen AU - Saadeh N AD - Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, JOR. FAU - Shahrour, Ghada AU - Shahrour G AD - Psychiatric Nursing, Faculty of Nursing, Jordan University of Science and Technology, Irbid, JOR. LA - eng PT - Journal Article DEP - 20240816 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC11402071 OTO - NOTNLM OT - covid-19 pandemic OT - dietary behaviours OT - jordan OT - nutritional epidemiology OT - physical activity OT - questionnaire validation OT - school children COIS- Human subjects: Consent was obtained or waived by all participants in this study. Ethics Committee of the National University of Malaysia issued approval JEP-2022-590. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2024/09/17 10:42 MHDA- 2024/09/17 10:43 PMCR- 2024/08/16 CRDT- 2024/09/16 06:03 PHST- 2024/08/15 00:00 [accepted] PHST- 2024/09/17 10:43 [medline] PHST- 2024/09/17 10:42 [pubmed] PHST- 2024/09/16 06:03 [entrez] PHST- 2024/08/16 00:00 [pmc-release] AID - 10.7759/cureus.66980 [doi] PST - epublish SO - Cureus. 2024 Aug 16;16(8):e66980. doi: 10.7759/cureus.66980. eCollection 2024 Aug. PMID- 39279236 OWN - NLM STAT- MEDLINE DCOM- 20241222 LR - 20241222 IS - 1532-2491 (Electronic) IS - 1082-6084 (Linking) VI - 60 IP - 1 DP - 2025 TI - Associations Between Motivations for Cannabis Use and "the Munchies": Construct Validity of the Cannabinoid Eating Experience Questionnaire. PG - 20-27 LID - 10.1080/10826084.2024.2403121 [doi] AB - BACKGROUND: The Cannabis Eating Experience Questionnaire (CEEQ) was developed and validated with a two-factor structure for the assessment of cannabis effects on both the appetitive factors that initiate eating and the hedonic factors that maintain an eating episode. The relationship between the CEEQ and cannabis use motives has not yet been considered. The study aimed to confirm the two-factor structure of the CEEQ and explore associations with the five-factor Marijuana Motives Questionnaire (MMQ). METHOD: Cannabis users (N = 546) completed the CEEQ alongside the MMQ in an online survey. RESULTS: Confirmatory factor analysis (CFA) confirmed the two-factor structure of the CEEQ and the five-factor structure of the MMQ. Structural equation modeling (SEM) tested associations between each factor of the CEEQ and cannabis use motives. Cannabis use motives of "enhancement" and "conformity" were both positively associated with "hedonic" and "appetitive" subscales of the CEEQ, and "coping" was associated with increased "appetitive" scores. The "social" cannabis use motive was negatively associated with both "hedonic" and "appetitive" subscales on CEEQ, and "expansion" was negatively associated with the "appetitive" subscale. CONCLUSION: We provide further support for the construct validity of the CEEQ that provides a useful assessment of cannabis effects on hedonic and appetitive aspects of eating and show for the first time that cannabis use motives influence eating experiences in distinct ways. Further understanding of the relationship between cannabis use motives and the effects of cannabis on appetite may prove a useful for informing therapeutic applications of cannabis stimulating appetite or promoting weight gain. FAU - Davies-Owen, Jennifer AU - Davies-Owen J AD - Department of Psychological Sciences, Institute of Population Health, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UKingdom. FAU - Christiansen, Paul AU - Christiansen P AD - Department of Psychological Sciences, Institute of Population Health, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UKingdom. FAU - Roberts, Carl Alexander AU - Roberts CA AD - Department of Psychological Sciences, Institute of Population Health, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UKingdom. LA - eng PT - Journal Article DEP - 20240915 PL - England TA - Subst Use Misuse JT - Substance use & misuse JID - 9602153 SB - IM MH - Humans MH - *Motivation MH - Male MH - Female MH - Adult MH - Surveys and Questionnaires MH - Young Adult MH - Adolescent MH - Marijuana Use/psychology MH - Factor Analysis, Statistical MH - Eating/psychology MH - Reproducibility of Results MH - Feeding Behavior/psychology MH - Middle Aged OTO - NOTNLM OT - Cannabis OT - appetite OT - cannabinoids OT - eating OT - munchies OT - questionnaire EDAT- 2024/09/16 06:22 MHDA- 2024/12/22 12:19 CRDT- 2024/09/16 01:53 PHST- 2024/12/22 12:19 [medline] PHST- 2024/09/16 06:22 [pubmed] PHST- 2024/09/16 01:53 [entrez] AID - 10.1080/10826084.2024.2403121 [doi] PST - ppublish SO - Subst Use Misuse. 2025;60(1):20-27. doi: 10.1080/10826084.2024.2403121. Epub 2024 Sep 15. PMID- 39279068 OWN - NLM STAT- MEDLINE DCOM- 20240916 LR - 20240916 IS - 0030-9982 (Print) IS - 0030-9982 (Linking) VI - 74 IP - 9 DP - 2024 Sep TI - Assessment of barriers to the dietary adherence among type 2 diabetic patients in Pakistan: A cross-sectional study. PG - 1638-1644 LID - 10.47391/JPMA.10782 [doi] AB - OBJECTIVE: To assess the common barriers responsible for non-adherence to dietary recommendations among type 2 diabetic patients. METHODS: The cross-sectional study was conducted from October 4, 2021, to March 6, 2022, at the National Institute of Diabetes and Endocrinology, Dow University of Health Sciences, Karachi, and comprised type 2 diabetes patients of either gender aged 18-80 years who had previously been given recommended dietary advice. Dietary barriers were assessed using a 27-item validated questionnaire, and the subjects were compared in terms of age and diabetes duration. Anthropometric measurements and laboratory parameters were also measured. Data were analysed using Stata 17. RESULTS: Of the 312 subjects, 234(75%) were females. The overall mean age was 52.2+/-11.2 years, and mean body mass index was 27.2+/-5.5kg/m2. The reliability of the questionnaire was established with Cronbach's alpha 0.89. Factor analysis yielded 8 common barriers; lack of knowledge about dietary recommendations (variance: 14.7%), situational barrier (variance: 10.7%), lack of family support (variance: 9.5%), stress-related eating problems (variance: 9.1%), boring and monotonous diet (variance: 8.0%), expensive and ineffective diet recommended (variance: 6.5%), work conditions/don't like food in diet (variance: 5.5%), and feeling hungry and weak (variance: 5.4%). The total variation explained by all the 8 factors was 69.4%. CONCLUSIONS: Lack of knowledge regarding dietary recommendations was reported to be the most common barrier towards recommended dietary adherence. FAU - Shabbir, Sukaina AU - Shabbir S AD - School of Public Health, Dow University Health Sciences, Ojha Campus, Karachi, Pakistan. FAU - Amer, Mehreen AU - Amer M AD - School of Public Health, Dow University Health Sciences, Ojha Campus, Karachi, Pakistan. FAU - Mughal, Saba AU - Mughal S AD - School of Public Health, Dow University Health Sciences, Ojha Campus, Karachi, Pakistan. FAU - Rashid, Thamina AU - Rashid T AD - National Institute of Diabetes and Endocrinology, Dow University Health Sciences, Karachi, Pakistan. CN - Habiba AD - Food Science Lab, School of Public Health, Dow University Health Sciences, Ojha Campus, Karachi, Pakistan. LA - eng PT - Journal Article PL - Pakistan TA - J Pak Med Assoc JT - JPMA. The Journal of the Pakistan Medical Association JID - 7501162 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/diet therapy MH - Female MH - Male MH - Middle Aged MH - Pakistan MH - Cross-Sectional Studies MH - Adult MH - *Patient Compliance/statistics & numerical data MH - *Health Knowledge, Attitudes, Practice MH - Aged MH - Surveys and Questionnaires MH - Young Adult MH - Adolescent MH - Social Support MH - Feeding Behavior OTO - NOTNLM OT - Diabetes mellitus, Type 2 diabetes, Dietary adherence, Barriers, Non-adherence, Dietary advice. EDAT- 2024/09/16 06:22 MHDA- 2024/09/16 06:23 CRDT- 2024/09/16 00:13 PHST- 2024/09/16 06:23 [medline] PHST- 2024/09/16 06:22 [pubmed] PHST- 2024/09/16 00:13 [entrez] AID - 10.47391/JPMA.10782 [doi] PST - ppublish SO - J Pak Med Assoc. 2024 Sep;74(9):1638-1644. doi: 10.47391/JPMA.10782. PMID- 39267587 OWN - NLM STAT- MEDLINE DCOM- 20241217 LR - 20241217 IS - 1475-097X (Electronic) IS - 1475-0961 (Linking) VI - 45 IP - 1 DP - 2025 Jan TI - 'Effects of dehydration on central blood pressure in young healthy adults'. PG - 26-32 LID - 10.1111/cpf.12902 [doi] AB - PURPOSE: Brachial blood pressure (BP) is the current gold standard for BP assessment; however, measures of pulse wave velocity (PWV) and central blood pressure (CBP) may contribute uniquely to assessment of cardiovascular health status. As of yet, standards for assessment of CBP and PWV have not addressed the impact of hydration status on proper measurement. To understand the impact of hydration, PWV and CBP should be measured in a euhydrated and hypohydrated state. METHODS: Forty-three young, healthy participants (21 +/- 2 years) completed a dehydration protocol utilizing moderate aerobic activity until they lost 1%-2% of their body weight. PWV and CBP were measured before and following the dehydration protocol. Linear regression was utilized to assess change in hydration status and change in PWV and CBP. RESULTS: No significant relationships were observed between the change in hydration status (% body weight lost) and PWV (beta = 0.05, p = 0.78) or central diastolic BP (beta = -3.8, p = 0.10), however, a significant relationship was observed with central systolic BP (beta = -5.0, p = 0.03). DISCUSSION: In conclusion, the assessment of hydration status before measurement of CBP or PWV may not be necessary in young, healthy individuals. CI - (c) 2024 Scandinavian Society of Clinical Physiology and Nuclear Medicine. FAU - Giddings, Madeleine L AU - Giddings ML AUID- ORCID: 0009-0004-2730-137X AD - Department of Kinesiology, Concordia University Irvine, Irvine, California, USA. FAU - Auringer, Jacob P AU - Auringer JP AUID- ORCID: 0009-0003-0440-511X AD - Department of Biology, Concordia University Irvine, Irvine, California, USA. FAU - Meier, Nathan F AU - Meier NF AUID- ORCID: 0000-0002-1558-3427 AD - Department of Kinesiology, Concordia University Irvine, Irvine, California, USA. FAU - Lefferts, Elizabeth C AU - Lefferts EC AUID- ORCID: 0000-0002-7538-8228 AD - Department of Kinesiology, Iowa State University, Ames, Iowa, USA. FAU - Wang, Chong AU - Wang C AUID- ORCID: 0000-0003-4489-4344 AD - Department of Statistics, Iowa State University, Ames, Iowa, USA. FAU - Kane-Barnese, Lindsay AU - Kane-Barnese L AUID- ORCID: 0009-0003-4045-6360 AD - Department of Biology, Concordia University Irvine, Irvine, California, USA. LA - eng GR - Concordia University Irvine/ PT - Journal Article DEP - 20240913 PL - England TA - Clin Physiol Funct Imaging JT - Clinical physiology and functional imaging JID - 101137604 SB - IM MH - Humans MH - *Dehydration/physiopathology/diagnosis MH - Male MH - Young Adult MH - Female MH - *Blood Pressure MH - *Healthy Volunteers MH - *Pulse Wave Analysis/methods MH - *Organism Hydration Status MH - Predictive Value of Tests MH - Time Factors MH - Weight Loss MH - Age Factors MH - Linear Models MH - Adolescent MH - Adult MH - Reproducibility of Results MH - Vascular Stiffness MH - Exercise/physiology OTO - NOTNLM OT - pulse wave analysis OT - pulse wave velocity EDAT- 2024/09/15 21:16 MHDA- 2024/12/17 12:31 CRDT- 2024/09/13 04:03 PHST- 2024/08/24 00:00 [revised] PHST- 2024/06/13 00:00 [received] PHST- 2024/08/30 00:00 [accepted] PHST- 2024/12/17 12:31 [medline] PHST- 2024/09/15 21:16 [pubmed] PHST- 2024/09/13 04:03 [entrez] AID - 10.1111/cpf.12902 [doi] PST - ppublish SO - Clin Physiol Funct Imaging. 2025 Jan;45(1):26-32. doi: 10.1111/cpf.12902. Epub 2024 Sep 13. PMID- 39275821 OWN - NLM STAT- MEDLINE DCOM- 20240914 LR - 20240914 IS - 1557-5268 (Electronic) IS - 1053-4628 (Linking) VI - 48 IP - 5 DP - 2024 Sep TI - Associations between risk factors, including approximal contact types and dental caries in children from low-income families. Pilot study. PG - 60-68 LID - 10.22514/jocpd.2024.104 [doi] AB - The present cross-sectional study was conducted to evaluate various caries risk factors in children from low socio-economic groups and to assess if children with broad contacts between one or more primary molars (type I and S) should be categorized as at high caries risk. Clinical examinations were performed on 107, 3- to 10-year-old children from low socio-economic settings. Contact types along with other caries risk factors (insurance, diet, plaque, and fluoride use, and diet habits) were analyzed for effect on presence of caries lesions (prevalence) and caries experience (decayed, missing, filled teeth). 78% of the study population had dental caries lesions, with an average dmft of 5.6. Of the 277 evaluated contacts, 88% were categorized as broad contacts. Multivariate analyses failed to validate that broad contacts were a predictor of dental caries lesions. However, the analysis showed an association of insurance status, plaque index with dmft. In conclusion, the present study could not implicate broad contacts as a factor that increased caries risk in the studied population; however, it validates the importance of insurance status, plaque index, as well as diet frequency as predictors of dental caries lesions. CI - (c)2024 The Author(s). Published by MRE Press. FAU - Jaafar, Ameena AU - Jaafar A AD - Division of Pediatric Dentistry, Department of Orthodontics and Pediatric Dentistry, University of Maryland School of Dentistry, Baltimore, MD 21201, USA. FAU - Dhar, Vineet AU - Dhar V AD - Division of Pediatric Dentistry, Department of Orthodontics and Pediatric Dentistry, University of Maryland School of Dentistry, Baltimore, MD 21201, USA. FAU - Hsu, Kuei-Ling AU - Hsu KL AD - Division of Pediatric Dentistry, Department of Orthodontics and Pediatric Dentistry, University of Maryland School of Dentistry, Baltimore, MD 21201, USA. FAU - Tinanoff, Norman AU - Tinanoff N AD - Division of Pediatric Dentistry, Department of Orthodontics and Pediatric Dentistry, University of Maryland School of Dentistry, Baltimore, MD 21201, USA. LA - eng GR - SOD10065-210/University of Maryland School of Dentistry IN-SPIRE Grant Program/ PT - Journal Article DEP - 20240903 PL - Singapore TA - J Clin Pediatr Dent JT - The Journal of clinical pediatric dentistry JID - 9100079 RN - Q80VPU408O (Fluorides) SB - IM MH - Humans MH - *Dental Caries/epidemiology MH - Child MH - Pilot Projects MH - Risk Factors MH - Cross-Sectional Studies MH - Child, Preschool MH - Male MH - Female MH - *Poverty MH - DMF Index MH - Dental Plaque Index MH - Feeding Behavior MH - Tooth, Deciduous MH - Prevalence MH - Diet MH - Molar MH - Fluorides/therapeutic use MH - Insurance Coverage OTO - NOTNLM OT - Caries risk OT - OXIS contacts OT - Primary dentition COIS- The authors declare no conflict of interest. EDAT- 2024/09/14 10:42 MHDA- 2024/09/14 10:43 CRDT- 2024/09/14 02:32 PHST- 2024/02/18 00:00 [received] PHST- 2024/04/17 00:00 [accepted] PHST- 2024/09/14 10:43 [medline] PHST- 2024/09/14 10:42 [pubmed] PHST- 2024/09/14 02:32 [entrez] AID - S1053-4628(24)00187-5 [pii] AID - 10.22514/jocpd.2024.104 [doi] PST - ppublish SO - J Clin Pediatr Dent. 2024 Sep;48(5):60-68. doi: 10.22514/jocpd.2024.104. Epub 2024 Sep 3. PMID- 39275345 OWN - NLM STAT- MEDLINE DCOM- 20240914 LR - 20260923 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 17 DP - 2024 Sep 8 TI - Evaluating Emotional Eating in Children from the Perspective of Parents: Psychometric Properties of the Parent Version of the Emotional Eating Scale Adapted for Children and Adolescents. LID - 10.3390/nu16173030 [doi] LID - 3030 AB - BACKGROUND: Emotional eating is associated with adverse health outcomes in children, including elevated weight status. Currently, there is not a well-validated parent-report measure of emotional eating for young children. This study assessed the reliability and validity of the 10-item parent version of the Emotional Eating Scale Adapted for Children and Adolescents (EES-C) Short-Form. METHODS: The participants were 207 parents and 144 children from the southern United States. They completed the parent- and child-report EES-C Short-Form and responded to measures related to child eating behaviors, mood, and gratitude. RESULTS: The parent-report EES-C Short-Form demonstrated good internal consistency reliability (Cronbach's alpha = 0.94). Test-retest reliability was also supported, as evidenced by a medium correlation (ICC = 0.56, p < 0.001) between parent-rated emotional eating across two time points. Additionally, the measure demonstrated a significant correlation with a scale of emotional overeating (r = 0.25, p < 0.001)-a theoretically related construct. Supporting discriminant validity, the measure was not significantly related to a measure of parent-reported gratitude (r = 0.07, p = 0.30). A unidimensional model provided good fit for the data (CFI = 0.997, SRMR = 0.046). CONCLUSIONS: The results from the current study provide preliminary evidence supporting the reliability and validity of the parent version of the EES-C Short-Form. For the purpose of screening children in school or primary care settings, the EES-C Short-Form may be practical and helpful in identifying children who may be at risk of developing adverse health outcomes or more-severe eating disorder pathology. FAU - Summers, Emma AU - Summers E AD - Department of Psychology and Neuroscience, Baylor University, Waco, TX 76706, USA. FAU - Limbers, Christine A AU - Limbers CA AUID- ORCID: 0000-0002-4880-1865 AD - Department of Psychology and Neuroscience, Baylor University, Waco, TX 76706, USA. LA - eng PT - Journal Article PT - Validation Study DEP - 20240908 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - *Parents/psychology MH - *Psychometrics MH - *Emotions MH - Reproducibility of Results MH - *Feeding Behavior/psychology MH - Adolescent MH - Surveys and Questionnaires/standards MH - Adult MH - Child Behavior/psychology MH - Eating/psychology PMC - PMC11397218 OTO - NOTNLM OT - Emotional Eating Scale for Children and Adolescents OT - emotional eating OT - parent perspectives COIS- The authors declare no conflicts of interest. EDAT- 2024/09/14 10:46 MHDA- 2024/09/14 10:47 PMCR- 2024/09/08 CRDT- 2024/09/14 01:19 PHST- 2024/08/07 00:00 [received] PHST- 2024/09/05 00:00 [revised] PHST- 2024/09/07 00:00 [accepted] PHST- 2024/09/14 10:47 [medline] PHST- 2024/09/14 10:46 [pubmed] PHST- 2024/09/14 01:19 [entrez] PHST- 2024/09/08 00:00 [pmc-release] AID - nu16173030 [pii] AID - nutrients-16-03030 [pii] AID - 10.3390/nu16173030 [doi] PST - epublish SO - Nutrients. 2024 Sep 8;16(17):3030. doi: 10.3390/nu16173030. PMID- 39275330 OWN - NLM STAT- MEDLINE DCOM- 20240914 LR - 20240916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 17 DP - 2024 Sep 6 TI - Food Neophobia in Children Aged 1-6 Years-Between Disorder and Autonomy: Assessment of Food Preferences and Eating Patterns. LID - 10.3390/nu16173015 [doi] LID - 3015 AB - Food neophobia, defined as fear or aversion to eating new or unfamiliar foods, is a significant challenge, especially in the context of preschool children. In the scientific literature, this phenomenon is often described as a natural developmental stage, but its severity and impact on preferences and eating patterns still raise many questions. The purpose of the present study was to assess the prevalence of food neophobia in children aged 1 to 6 years and to analyze its relationship with eating habits, preferences, and eating patterns. The study was conducted using a proprietary questionnaire and validated research tools such as the Child Feeding Scale (MCH-FS) and Food Neophobia Scale (FNS). The study included 345 children, of whom 59.1% were observed to be at significant risk for food neophobia. The results of the study suggest that food neophobia is not a common phenomenon in children aged 1-2 years but becomes more pronounced later in childhood. Another important finding was that food neophobia shows a stronger association with established eating patterns than with individual taste preferences. Considering these results, this phenomenon should be considered not only as a natural part of child development, but also as a potential indicator of eating disorders that may require intervention. These findings underscore the need for further research that could deepen the understanding of the mechanisms governing food neophobia and its long-term consequences for child health. FAU - Krupa-Kotara, Karolina AU - Krupa-Kotara K AUID- ORCID: 0000-0001-9330-0771 AD - Department of Epidemiology, Faculty of Public Health in Bytom, Silesian Medical University in Katowice, 41-902 Bytom, Poland. FAU - Nowak, Beata AU - Nowak B AD - Department of Epidemiology, Faculty of Public Health in Bytom, Silesian Medical University in Katowice, 41-902 Bytom, Poland. FAU - Markowski, Jaroslaw AU - Markowski J AD - Department of Laryngology, Faculty of Medical Sciences, Silesian Medical University in Katowice, 40-055 Katowice, Poland. FAU - Rozmiarek, Mateusz AU - Rozmiarek M AUID- ORCID: 0000-0002-5955-0790 AD - Department of Sports Tourism, Faculty of Physical Culture Sciences, Poznan University of Physical Education, 61-871 Poznan, Poland. FAU - Grajek, Mateusz AU - Grajek M AUID- ORCID: 0000-0001-6588-8598 AD - Department of Public Health, Faculty of Public Health in Bytom, Silesian Medical University in Katowice, 41-902 Bytom, Poland. LA - eng PT - Journal Article DEP - 20240906 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Food Preferences/psychology MH - Child, Preschool MH - Female MH - Male MH - Infant MH - *Feeding Behavior/psychology MH - Child MH - Surveys and Questionnaires MH - Avoidant Restrictive Food Intake Disorder MH - Feeding and Eating Disorders/psychology/epidemiology MH - Child Behavior/psychology PMC - PMC11396904 OTO - NOTNLM OT - child feeding patterns OT - children OT - feeding difficulties OT - food neophobia OT - parents OT - pediatric feeding disorders COIS- The authors declare no conflicts of interest. EDAT- 2024/09/14 10:42 MHDA- 2024/09/14 10:43 PMCR- 2024/09/06 CRDT- 2024/09/14 01:19 PHST- 2024/08/15 00:00 [received] PHST- 2024/09/02 00:00 [revised] PHST- 2024/09/05 00:00 [accepted] PHST- 2024/09/14 10:43 [medline] PHST- 2024/09/14 10:42 [pubmed] PHST- 2024/09/14 01:19 [entrez] PHST- 2024/09/06 00:00 [pmc-release] AID - nu16173015 [pii] AID - nutrients-16-03015 [pii] AID - 10.3390/nu16173015 [doi] PST - epublish SO - Nutrients. 2024 Sep 6;16(17):3015. doi: 10.3390/nu16173015. PMID- 39275284 OWN - NLM STAT- MEDLINE DCOM- 20240914 LR - 20240916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 17 DP - 2024 Sep 3 TI - Food Neophobia in Children: A Case Study in Federal District/Brazil. LID - 10.3390/nu16172962 [doi] LID - 2962 AB - A reluctance to eat and/or avoidance of novel foods is characterized as food neophobia (FN). FN restricts the diet to familiar foods when, in fact, it should be much more varied. FN can be a barrier to healthy foods, affecting the quality of diet, and impairing children's growth and development. Therefore, according to their caregivers' perceptions, this study aimed to evaluate FN in children from Federal District/Brazil. The Brazilian Children's Food Neophobia Questionnaire (BCFNeo), a specific instrument developed and validated in Brazil, was answered by caregivers of children aged 4 to 11 y/o. Sampling occurred through snowball recruitment, being convenient and non-probabilistic. The Health Sciences Ethics Committee approved the study. The analysis evaluated FN in total (BCFNeoTot) and in the following domains: general (FNgen), for fruits (FNfru), and for vegetables (FNveg). FN scores were compared between sex and child's age and categorized according to three ordinal levels. FN levels were compared using the Mann-Whitney U test. The Friedman test, followed by the Wilcoxon test with Bonferroni correction, was performed to analyze differences in FN according to the environment. Of the caregivers' answers for their children, 595 answers were included, because 19 were out of age. The prevalence of high FN was 42.9%. The domain with the highest prevalence of high FN was vegetables (48.6%). Children aged 8 to 11 y/o had a higher mean FN in two domains (FNgen p = 0.047 and FNveg p = 0.038) when compared to children aged 4 to 7 y/o. Boys were more neophobic in all domains (FNgen p = 0.017; FNfru p = 0.010; FNveg p = 0.013; BCFNeoTot p = 0.008), and FN tends not to decrease with age. The results showed that the children of the FD are more neophobic than Brazilian children in general, highlighting the importance of additional studies in FN determinants in this population and nutritional education interventions to reduce FN among FD children. FAU - De Almeida, Priscila Claudino AU - De Almeida PC AUID- ORCID: 0000-0001-9871-0112 AD - Graduate Program in Human Nutrition, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Nakano, Eduardo Yoshio AU - Nakano EY AUID- ORCID: 0000-0002-9071-8512 AD - Department of Statistics, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Vasconcelos, Ivana Aragao Lira AU - Vasconcelos IAL AUID- ORCID: 0000-0001-6543-7690 AD - Department of Nutrition, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Zandonadi, Renata Puppin AU - Zandonadi RP AUID- ORCID: 0000-0003-0370-3089 AD - Department of Nutrition, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Raposo, Antonio AU - Raposo A AUID- ORCID: 0000-0002-5286-2249 AD - CBIOS (Research Center for Biosciences and Health Technologies), Universidade Lusofona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisboa, Portugal. FAU - Saraiva, Ariana AU - Saraiva A AD - Department of Animal Pathology and Production, Bromatology and Food Technology, Faculty of Veterinary, Universidad de Las Palmas de Gran Canaria, Trasmontana s/n, 35413 Arucas, Spain. FAU - Alturki, Hmidan A AU - Alturki HA AUID- ORCID: 0000-0003-4359-063X AD - King Abdulaziz City for Science & Technology, Wellness and Preventive Medicine Institute-Health Sector, Riyadh 11442, Saudi Arabia. FAU - Botelho, Raquel Braz Assuncao AU - Botelho RBA AUID- ORCID: 0000-0002-0369-287X AD - Department of Nutrition, University of Brasilia, Brasilia 70910-900, Brazil. LA - eng PT - Journal Article DEP - 20240903 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Brazil/epidemiology MH - Male MH - Child MH - Female MH - Child, Preschool MH - Surveys and Questionnaires MH - *Avoidant Restrictive Food Intake Disorder MH - Food Preferences/psychology MH - Caregivers/psychology MH - Vegetables MH - Feeding Behavior/psychology MH - Fruit PMC - PMC11397450 OTO - NOTNLM OT - child OT - food neophobia OT - prevalence COIS- The authors declare no conflicts of interest. EDAT- 2024/09/14 10:45 MHDA- 2024/09/14 10:46 PMCR- 2024/09/03 CRDT- 2024/09/14 01:19 PHST- 2024/07/30 00:00 [received] PHST- 2024/08/31 00:00 [revised] PHST- 2024/09/02 00:00 [accepted] PHST- 2024/09/14 10:46 [medline] PHST- 2024/09/14 10:45 [pubmed] PHST- 2024/09/14 01:19 [entrez] PHST- 2024/09/03 00:00 [pmc-release] AID - nu16172962 [pii] AID - nutrients-16-02962 [pii] AID - 10.3390/nu16172962 [doi] PST - epublish SO - Nutrients. 2024 Sep 3;16(17):2962. doi: 10.3390/nu16172962. PMID- 39275214 OWN - NLM STAT- MEDLINE DCOM- 20240914 LR - 20241003 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 17 DP - 2024 Aug 29 TI - Development and Validation of a Pediatric Hospital-Acquired Malnutrition (PHaM) Risk Score to Predict Nutritional Deterioration in Hospitalized Pediatric Patients: A Secondary Analysis Based on a Multicenter Prospective Cohort Study. LID - 10.3390/nu16172898 [doi] LID - 2898 AB - (1) Background: Hospital-acquired malnutrition in pediatric patients leads to adverse outcomes. This study aimed to develop and validate a pediatric hospital-acquired malnutrition (PHaM) risk score to predict nutritional deterioration. (2) Methods: This was a derivative retrospective cohort study for developing a PHaM risk score. The study included data from children aged 1 month-18 years admitted to pediatric wards in four tertiary care hospitals for at least 72 h between December 2018 and May 2019. Data on pediatric patients' characteristics, medical history, nutritional status, gastrointestinal symptoms, and outcomes were used for tool development. Logistic regression identified risk factors for nutritional deterioration, defined as a decline in BMI z-score >/= 0.25 SD and/or >/=2% weight loss. A PHaM risk score was developed based on these factors and validated with an independent prospective cohort from July 2020 to March 2021. (3) Results: The study used a derivative cohort of 444 patients and a validation cohort of 373 patients. Logistic regression identified gastrointestinal symptoms, disease severity, fever, lower respiratory tract infection, and reduced food intake as predictors. The PHaM risk score (maximum 9 points) showed good discrimination and calibration (AUC 0.852, 95% CI: 0.814-0.891). Using a cut-off at 2.5 points, the scale had 63.0% sensitivity, 88.6% specificity, 76.1% positive predictive value, and 80.6% negative predictive value (NPV) when applied to the derivative cohort. The accuracy improved on the validation cohort, with 91.9% sensitivity and 93.0% NPV. (4) Conclusions: This PHaM risk score is a novel and probably effective tool for predicting nutritional deterioration in hospitalized pediatric patients, and its implementation in clinical practice could enhance nutritional care and optimize outcomes. FAU - Saengnipanthkul, Suchaorn AU - Saengnipanthkul S AUID- ORCID: 0000-0003-1368-9508 AD - Department of Pediatrics, Faculty of Medicine, Srinagarind Hospital, Khon Kaen University, Khon Kaen 40002, Thailand. FAU - Sirikarn, Prapassara AU - Sirikarn P AUID- ORCID: 0000-0001-5887-6716 AD - Department of Epidemiology and Biostatistics, Faculty of Public Health, Khon Kaen University, Khon Kaen 40002, Thailand. FAU - Chongviriyaphan, Nalinee AU - Chongviriyaphan N AD - Division of Nutrition, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand. FAU - Densupsoontorn, Narumon AU - Densupsoontorn N AD - Division of Nutrition, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. FAU - Phosuwattanakul, Jeeraparn AU - Phosuwattanakul J AD - Division of Nutrition, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand. FAU - Apiraksakorn, Amnuayporn AU - Apiraksakorn A AUID- ORCID: 0000-0003-2238-0481 AD - Department of Pediatrics, Khon Kaen Hospital, Khon Kaen 40000, Thailand. FAU - Sitthikarnkha, Phanthila AU - Sitthikarnkha P AUID- ORCID: 0000-0003-1245-837X AD - Department of Pediatrics, Faculty of Medicine, Srinagarind Hospital, Khon Kaen University, Khon Kaen 40002, Thailand. FAU - Techasatian, Leelawadee AU - Techasatian L AUID- ORCID: 0000-0003-4668-6792 AD - Department of Pediatrics, Faculty of Medicine, Srinagarind Hospital, Khon Kaen University, Khon Kaen 40002, Thailand. FAU - Uppala, Rattapon AU - Uppala R AUID- ORCID: 0000-0003-1903-0907 AD - Department of Pediatrics, Faculty of Medicine, Srinagarind Hospital, Khon Kaen University, Khon Kaen 40002, Thailand. FAU - Lumbiganon, Pagakrong AU - Lumbiganon P AD - Department of Pediatrics, Faculty of Medicine, Srinagarind Hospital, Khon Kaen University, Khon Kaen 40002, Thailand. LA - eng GR - IN64107/Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand/ GR - RP110/Research and Graduate studies, Khon Kaen University, Thailand./ PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20240829 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child, Preschool MH - Child MH - Male MH - Female MH - Infant MH - Prospective Studies MH - Risk Factors MH - Adolescent MH - *Malnutrition/diagnosis MH - *Nutritional Status MH - Hospitalization MH - Risk Assessment MH - Nutrition Assessment MH - Retrospective Studies MH - Hospitals, Pediatric MH - Logistic Models MH - Child Nutrition Disorders/diagnosis MH - Cohort Studies MH - Reproducibility of Results PMC - PMC11396899 OTO - NOTNLM OT - children OT - hospital-acquired malnutrition OT - nutritional deterioration OT - predictive score OT - validation COIS- The authors declare no conflicts of interest. EDAT- 2024/09/14 10:44 MHDA- 2024/09/14 10:45 PMCR- 2024/08/29 CRDT- 2024/09/14 01:18 PHST- 2024/06/14 00:00 [received] PHST- 2024/08/11 00:00 [revised] PHST- 2024/08/28 00:00 [accepted] PHST- 2024/09/14 10:45 [medline] PHST- 2024/09/14 10:44 [pubmed] PHST- 2024/09/14 01:18 [entrez] PHST- 2024/08/29 00:00 [pmc-release] AID - nu16172898 [pii] AID - nutrients-16-02898 [pii] AID - 10.3390/nu16172898 [doi] PST - epublish SO - Nutrients. 2024 Aug 29;16(17):2898. doi: 10.3390/nu16172898. PMID- 39275205 OWN - NLM STAT- MEDLINE DCOM- 20240914 LR - 20250211 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 17 DP - 2024 Aug 29 TI - Impact of Dietary Patterns on Metabolic Syndrome in Young Adults: A Cross-Sectional Study. LID - 10.3390/nu16172890 [doi] LID - 2890 AB - Metabolic syndrome has become a significant public health concern. This study aims to investigate the impact of dietary patterns on metabolic syndrome in young adults and how physical activity modulates this effect. A cross-sectional study was conducted at a health management center in Tianjin, China, from September 2022 to March 2023. Participants aged 18-35 years were recruited using convenience sampling. Dietary intake was assessed using a validated food frequency questionnaire. Logistic regression models evaluated associations between these patterns and metabolic syndrome, adjusting for potential confounders. Among 442 participants, four dietary patterns were identified: Legume-Nut, Alcohol-Meat, Sugar-Processed, and Egg-Vegetable. The Legume-Nut dietary pattern was associated with a higher risk of metabolic syndrome (OR = 2.63, 95% CI: 1.08-6.37), while the Egg-Vegetable dietary pattern was associated with a lower risk (OR = 0.26, 95% CI: 0.10-0.70). No significant associations were found for the Sugar-Processed and Alcohol-Meat patterns. Subgroup analysis revealed that the Legume-Nut pattern increased the risk of metabolic syndrome among those with irregular physical activity, whereas the Egg-Vegetable pattern decreased the risk. These findings highlight the significant influence of dietary patterns on the risk of metabolic syndrome in young adults and the modifying effect of regular physical activity, underscoring the need for targeted dietary and lifestyle interventions to prevent metabolic syndrome in this population. FAU - Liu, Jingwen AU - Liu J AUID- ORCID: 0009-0005-8220-0253 AD - School of Nursing, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin 300070, China. FAU - Lu, Wenfeng AU - Lu W AUID- ORCID: 0009-0003-8679-3020 AD - School of Nursing, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin 300070, China. FAU - Lv, Qingyun AU - Lv Q AD - School of Nursing, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin 300070, China. FAU - Wang, Yaqi AU - Wang Y AD - School of Nursing, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin 300070, China. FAU - Xu, Xueying AU - Xu X AD - School of Nursing, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin 300070, China. FAU - He, Yuan AU - He Y AD - School of Nursing, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin 300070, China. FAU - Chang, Hairong AU - Chang H AD - School of Nursing, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin 300070, China. FAU - Zhao, Yue AU - Zhao Y AD - School of Nursing, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin 300070, China. FAU - Zhang, Xiaonan AU - Zhang X AUID- ORCID: 0000-0002-9637-8408 AD - School of Nursing, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin 300070, China. FAU - Zang, Xiaoying AU - Zang X AD - School of Nursing, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin 300070, China. FAU - Zhang, Hua AU - Zhang H AD - School of Nursing, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin 300070, China. LA - eng GR - 72304206/National Natural Science Foundation of China/ GR - 72274134/National Natural Science Foundation of China/ GR - 23YJAZH189/Humanities and Social Science Fund of Ministry of Education of China/ GR - 2022XKZX-04/Nursing Special Development Fund of Tianjin Medical University/ PT - Journal Article DEP - 20240829 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Metabolic Syndrome/epidemiology/etiology MH - Cross-Sectional Studies MH - Young Adult MH - Male MH - Female MH - Adult MH - Adolescent MH - *Diet/statistics & numerical data MH - *Exercise MH - China/epidemiology MH - Feeding Behavior MH - Risk Factors MH - Fabaceae MH - Nuts MH - Vegetables PMC - PMC11397102 OTO - NOTNLM OT - cross-sectional study OT - dietary patterns OT - metabolic syndrome OT - subgroup analysis OT - young adults COIS- The authors declare no conflict of interest. EDAT- 2024/09/14 10:44 MHDA- 2024/09/14 10:45 PMCR- 2024/08/29 CRDT- 2024/09/14 01:18 PHST- 2024/07/02 00:00 [received] PHST- 2024/07/24 00:00 [revised] PHST- 2024/07/26 00:00 [accepted] PHST- 2024/09/14 10:45 [medline] PHST- 2024/09/14 10:44 [pubmed] PHST- 2024/09/14 01:18 [entrez] PHST- 2024/08/29 00:00 [pmc-release] AID - nu16172890 [pii] AID - nutrients-16-02890 [pii] AID - 10.3390/nu16172890 [doi] PST - epublish SO - Nutrients. 2024 Aug 29;16(17):2890. doi: 10.3390/nu16172890. PMID- 39270433 OWN - NLM STAT- MEDLINE DCOM- 20241107 LR - 20250728 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 128 DP - 2024 Dec TI - The mediating role of ability to delay gratification in the relationship between emotional abuse and dieting behavior in healthy adolescents: Considering body mass index as a covariate. PG - 112554 LID - S0899-9007(24)00203-X [pii] LID - 10.1016/j.nut.2024.112554 [doi] AB - OBJECTIVES: In the present study we investigated the relationship between interpersonal childhood trauma, ability to delay gratification (DG), and disordered eating attitudes among adolescents. METHODS: Data were collected from 145 adolescents aged 12 to 17 through an online survey distributed to parents and legal guardians. The sociodemographic data form, Childhood Trauma Questionnaire (CTQ), Eating Attitudes Test-26 (EAT-26), and Delaying Gratification Inventory were filled out by adolescents in the study. RESULTS: Sociodemographic data revealed a mean age of 15.07 +/- 1.64 years, with 62.8% females (n = 91). Correlation analyses revealed associations between body mass index (BMI), interpersonal childhood trauma experiences (measured by CTQ), and disordered eating attitudes (measured by EAT-26). Notably, emotional abuse correlated negatively with ability to DG and positively with dieting behavior. Mediation analysis showed that ability to DG partially mediated the relationship between emotional abuse and dieting behavior, even after controlling for BMI percentiles. CONCLUSIONS: These findings suggest that emotional abuse may influence disordered eating attitudes especially dieting behavior through its impact on ability to DG. Further research is warranted to validate these findings and explore intervention strategies for adolescents affected by interpersonal childhood trauma and disordered eating attitudes. CI - Copyright (c) 2024 Elsevier Inc. All rights reserved. FAU - Guler, Hasan Ali AU - Guler HA AD - Department of Child and Adolescent Psychiatry, Selcuk University Faculty of Medicine, Konya, Turkiye. Electronic address: dr.hasanaliguler@gmail.com. FAU - Albayrak, Ahmet AU - Albayrak A AD - Selcuk University Faculty of Medicine, Konya, Turkiye. FAU - Alsancak, Zeynep Bilge AU - Alsancak ZB AD - Selcuk University Faculty of Medicine, Konya, Turkiye. FAU - Sina Kilic, Tayyip AU - Sina Kilic T AD - Selcuk University Faculty of Medicine, Konya, Turkiye. FAU - Yavuz, Busra AU - Yavuz B AD - Selcuk University Faculty of Medicine, Konya, Turkiye. FAU - Koken, Hamide Ceren AU - Koken HC AD - Selcuk University Faculty of Medicine, Konya, Turkiye. FAU - Ozcan, Ismail Hakki AU - Ozcan IH AD - Selcuk University Faculty of Medicine, Konya, Turkiye. FAU - Cinkir, Sena AU - Cinkir S AD - Selcuk University Faculty of Medicine, Konya, Turkiye. FAU - Acar, Furkan Mirac AU - Acar FM AD - Selcuk University Faculty of Medicine, Konya, Turkiye. FAU - Teker, Ozge Sena AU - Teker OS AD - Selcuk University Faculty of Medicine, Konya, Turkiye. FAU - Ozcaglayan, Sinem Ezgi AU - Ozcaglayan SE AD - Selcuk University Faculty of Medicine, Konya, Turkiye. FAU - Cakmakci, Zeynep Berra AU - Cakmakci ZB AD - Selcuk University Faculty of Medicine, Konya, Turkiye. FAU - Rajab, Fares AU - Rajab F AD - Selcuk University Faculty of Medicine, Konya, Turkiye. LA - eng PT - Journal Article DEP - 20240808 PL - United States TA - Nutrition JT - Nutrition (Burbank, Los Angeles County, Calif.) JID - 8802712 SB - IM MH - Humans MH - Female MH - Adolescent MH - Male MH - *Body Mass Index MH - Surveys and Questionnaires MH - Child MH - *Feeding and Eating Disorders/psychology MH - *Adolescent Behavior/psychology MH - Feeding Behavior/psychology MH - Delay Discounting MH - Emotions OTO - NOTNLM OT - Adolescents OT - Body mass index OT - Delay gratification OT - Disordered eating attitudes OT - Interpersonal trauma COIS- Declaration of competing interest The authors report there are no competing interests to declare. EDAT- 2024/09/14 10:42 MHDA- 2024/11/13 14:01 CRDT- 2024/09/13 18:03 PHST- 2024/05/28 00:00 [received] PHST- 2024/07/22 00:00 [revised] PHST- 2024/08/05 00:00 [accepted] PHST- 2024/11/13 14:01 [medline] PHST- 2024/09/14 10:42 [pubmed] PHST- 2024/09/13 18:03 [entrez] AID - S0899-9007(24)00203-X [pii] AID - 10.1016/j.nut.2024.112554 [doi] PST - ppublish SO - Nutrition. 2024 Dec;128:112554. doi: 10.1016/j.nut.2024.112554. Epub 2024 Aug 8. PMID- 39268713 OWN - NLM STAT- MEDLINE DCOM- 20240913 LR - 20260702 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 27 IP - 1 DP - 2024 Sep 13 TI - Phase angle is inversely related to the consumption of ultra-processed foods and positively related to the consumption of minimally processed foods by university students: a cross-sectional study. PG - e161 LID - 10.1017/S136898002400123X [doi] LID - e161 AB - OBJECTIVE: Ultra-processed foods (UPF) and minimally processed foods (MPF) consumption are differentially connected to adiposity and possibly body composition. Phase angle (PhA) originates from bioelectrical impedance analysis (BIA) and is connected to cellular health. This study is the first to investigate associations between UPF/MPF consumption and PhA. DESIGN: A cross-sectional study was conducted. Anthropometrical and BIA were performed. The Hellenic Physical Activity Questionnaire was used for physical activity evaluation, while a validated FFQ was used for dietary assessment. UPF and MPF intake (% energy) were determined according to the NOVA system. Partial correlation coefficients of PhA and dietary variables were assessed after multi-adjustment. PARTICIPANTS: Students were recruited (n 151, 114 women). SETTING: University. RESULTS: Median and interquartile range (IQR) of PhA were 5.5 degrees (5.1-6.4 degrees ) in the total sample, 6.8 degrees (6.1-7.3 degrees ) in men and 5.3 degrees (5.1-5.9 degrees ) in women (P < 0.001). The median and IQR for UPF consumption was 13.7 (8.1-33.4) % in the total sample, 23.8 (8.1-70.5) % in men and 12.9 (8.1-27.5) % in women (P < 0.001). The mean (sd) of MPF consumption was 60.2 (sd 15.7) % for the total sample, 59.1 (sd 16.4) % for men and 60.5 (sd 15.6) % for women (P = 0.720). The consumption of UPF was negatively (rho = -0.267, P = 0.002), while the consumption of MPF was positively (rho = 0.218, P = 0.010) associated with the PhA, after adjustment for age, sex, BMI and physical activity. CONCLUSION: PhA relates inversely to UPF and positively to MPF consumption. The observed associations possibly reflect the effects of diet on cellular health and in turn PhA. FAU - Detopoulou, Paraskevi AU - Detopoulou P AD - Department of Clinical Nutrition, General Hospital Korgialenio Benakio, Athens, Greece. AD - Department of Nutritional Sciences and Dietetics, University of the Peloponnese, Kalamata24100, Greece. FAU - Levidi, Despoina AU - Levidi D AUID- ORCID: 0009-0002-6154-7395 AD - Department of Nutritional Sciences and Dietetics, University of the Peloponnese, Kalamata24100, Greece. FAU - Magni, Olga AU - Magni O AD - Department of Nutritional Sciences and Dietetics, University of the Peloponnese, Kalamata24100, Greece. FAU - Dedes, Vassilios AU - Dedes V AD - Department of Nutritional Sciences and Dietetics, University of the Peloponnese, Kalamata24100, Greece. FAU - Tzoutzou, Milia AU - Tzoutzou M AD - Department of Nutritional Sciences and Dietetics, University of the Peloponnese, Kalamata24100, Greece. FAU - Fappa, Evaggelia AU - Fappa E AUID- ORCID: 0000-0002-7960-3378 AD - Department of Nutritional Sciences and Dietetics, University of the Peloponnese, Kalamata24100, Greece. FAU - Gioxari, Aristea AU - Gioxari A AD - Department of Nutritional Sciences and Dietetics, University of the Peloponnese, Kalamata24100, Greece. FAU - Panoutsopoulos, Georgios AU - Panoutsopoulos G AD - Department of Nutritional Sciences and Dietetics, University of the Peloponnese, Kalamata24100, Greece. LA - eng PT - Journal Article DEP - 20240913 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Male MH - *Students/statistics & numerical data MH - Young Adult MH - Universities MH - *Fast Foods/statistics & numerical data MH - *Diet/statistics & numerical data MH - Adult MH - *Food Handling MH - Electric Impedance MH - Body Composition MH - Exercise MH - Surveys and Questionnaires MH - Adiposity MH - Adolescent MH - Feeding Behavior MH - Food, Processed PMC - PMC11504085 OTO - NOTNLM OT - Minimally processed foods OT - Phase angle OT - Students OT - Ultra-processed foods COIS- The authors have no conflict of interest. EDAT- 2024/09/13 14:45 MHDA- 2024/09/13 14:46 PMCR- 2024/09/13 CRDT- 2024/09/13 05:53 PHST- 2024/09/13 14:46 [medline] PHST- 2024/09/13 14:45 [pubmed] PHST- 2024/09/13 05:53 [entrez] PHST- 2024/09/13 00:00 [pmc-release] AID - S136898002400123X [pii] AID - 10.1017/S136898002400123X [doi] PST - epublish SO - Public Health Nutr. 2024 Sep 13;27(1):e161. doi: 10.1017/S136898002400123X. PMID- 39268475 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260923 IS - 2398-502X (Print) IS - 2398-502X (Electronic) IS - 2398-502X (Linking) VI - 7 DP - 2022 TI - Inflammation proteomics datasets in the ALSPAC cohort. PG - 277 LID - 10.12688/wellcomeopenres.18482.2 [doi] LID - 277 AB - Proteomics is the identification, detection and quantification of proteins within a biological sample. The complete set of proteins expressed by an organism is known as the proteome. The availability of new high-throughput proteomic technologies, such as Olink Proteomic Proximity Extension Assay (PEA) technology has enabled detailed investigation of the circulating proteome in large-scale epidemiological studies. In particular, the Olink(R) Target 96 inflammatory panel allows the measurement of 92 circulating inflammatory proteins. The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort study which recruited pregnant women in 1991-1992 and has followed these women, their partners, and their offspring ever since. In this data note, we describe the newly-released proteomic data available in ALSPAC. Ninety-two proteins were analysed in 9000 blood plasma samples using the Olink(R) Target 96 inflammatory panel. Samples were derived from 2968 fasted mothers (mean age 47.5; Focus on Mothers 1 (FOM1)), 3005 non-fasted offspring at age 9 (Focus@9) and 3027 fasted offspring at age 24 (Focus@24). Post sample filtering, 1834 offspring have data at both timepoints and 1119 of those have data from their mother available. We performed quality control analyses using a standardised data processing workflow ( metaboprep) to produce a filtered dataset of 8983 samples for researchers to use in future analyses. Initial validation analyses indicate that IL-6 measured using the Olink(R) Target 96 inflammatory panel is highly correlated with IL-6 previously measured by clinical chemistry (Pearson's correlation = 0.77) and we are able to reproduce the reported positive correlation between body mass index (BMI) and IL-6. The pre-processing and validation analyses indicate a rich proteomic dataset to further characterise the role of inflammation in health and disease. CI - Copyright: (c) 2024 Goulding N et al. FAU - Goulding, Neil AU - Goulding N AUID- ORCID: 0000-0002-2488-4598 AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. FAU - Goudswaard, Lucy J AU - Goudswaard LJ AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. AD - Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, UK. FAU - Hughes, David A AU - Hughes DA AUID- ORCID: 0000-0002-9644-8998 AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. AD - Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, UK. FAU - Corbin, Laura J AU - Corbin LJ AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. AD - Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, UK. FAU - Groom, Alix AU - Groom A AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. AD - Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, UK. FAU - Ring, Susan AU - Ring S AUID- ORCID: 0000-0003-3103-9330 AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. AD - Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, UK. FAU - Timpson, Nicholas J AU - Timpson NJ AUID- ORCID: 0000-0002-7141-9189 AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. AD - Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, UK. FAU - Fraser, Abigail AU - Fraser A AUID- ORCID: 0000-0002-7741-9470 AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. AD - Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, UK. FAU - Northstone, Kate AU - Northstone K AUID- ORCID: 0000-0002-0602-1983 AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. FAU - Suderman, Matthew AU - Suderman M AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. AD - Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, UK. LA - eng GR - WT_/Wellcome Trust/United Kingdom PT - Journal Article DEP - 20240206 PL - England TA - Wellcome Open Res JT - Wellcome open research JID - 101696457 PMC - PMC11391261 OTO - NOTNLM OT - ALSPAC OT - Olink OT - Proteomics OT - birth cohort OT - inflammation OT - inter-generational COIS- No competing interests were disclosed. EDAT- 2024/09/13 23:43 MHDA- 2024/09/13 23:44 PMCR- 2024/02/06 CRDT- 2024/09/13 04:25 PHST- 2024/01/30 00:00 [accepted] PHST- 2024/09/13 23:44 [medline] PHST- 2024/09/13 23:43 [pubmed] PHST- 2024/09/13 04:25 [entrez] PHST- 2024/02/06 00:00 [pmc-release] AID - 10.12688/wellcomeopenres.18482.2 [doi] PST - epublish SO - Wellcome Open Res. 2024 Feb 6;7:277. doi: 10.12688/wellcomeopenres.18482.2. eCollection 2022. PMID- 39267136 OWN - NLM STAT- MEDLINE DCOM- 20240913 LR - 20260327 IS - 2072-1315 (Electronic) IS - 1606-0997 (Print) IS - 1606-0997 (Linking) VI - 43 IP - 1 DP - 2024 Sep 12 TI - Factorial validation of the children's eating behavior questionnaire and the association between the eating behaviors assessed and BMI Z score in Chinese preschoolers aged 2-5 years. PG - 145 LID - 10.1186/s41043-024-00634-z [doi] LID - 145 AB - OBJECTIVE: This study aimed to evaluate the validity and reliability of the Children's Eating Behavior Questionnaire (CEBQ) among Chinese preschool children aged 2-5 years. Additionally, we investigated the associations between eating behaviors assessed by the CEBQ and body mass index (BMI). METHODS: A cross-sectional study was conducted with a sample of Chinese preschool children aged 2 to 5 years (n = 11,780). The CEBQ was employed to assess participants' eating behaviors, and factor analysis of the CEBQ was conducted; sex and age differences in eating behaviors were examined. Correlations between children's BMI z scores and eating behaviors were analyzed via linear regression analysis controlling for age; sex; ethnicity; maternal age, education level, ethnicity and BMI; paternal age, education level, ethnicity and BMI. RESULTS: The factor analysis confirmed the eight-factor structure of the CEBQ, which explained 67.57% of the total variance. Two items were excluded owing to low factor loadings. The subscales showed satisfactory internal reliability (Cronbach's alpha range: 0.76-0.90). Significant sex and age differences were observed for several CEBQ subscales, and BMI z scores were found to be associated with various eating behavior subscales. CONCLUSIONS: This study's findings support the validity and reliability of the CEBQ for assessing eating behaviors among Chinese preschool children, and children's eating behaviors might be affected by age and sex. Furthermore, BMI was found to be associated with specific eating behaviors. Understanding these associations can inform interventions that promote healthy eating habits in this population. CI - (c) 2024. The Author(s). FAU - Mou, Jinsong AU - Mou J AD - Pingshan District Maternal & Child Healthcare Hospital of Shenzhen, Shenzhen, 518118, China. moujs@foxmail.com. FAU - Zhou, Haishan AU - Zhou H AD - Pingshan District Maternal & Child Healthcare Hospital of Shenzhen, Shenzhen, 518118, China. FAU - Huang, Shiya AU - Huang S AD - Pingshan District Maternal & Child Healthcare Hospital of Shenzhen, Shenzhen, 518118, China. FAU - Feng, Zhangui AU - Feng Z AD - Pingshan District Maternal & Child Healthcare Hospital of Shenzhen, Shenzhen, 518118, China. LA - eng GR - 202183/WT_/Wellcome Trust/United Kingdom GR - 202183/WT_/Wellcome Trust/United Kingdom GR - 202183/WT_/Wellcome Trust/United Kingdom GR - 202183/WT_/Wellcome Trust/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20240912 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 SB - IM MH - Humans MH - Child, Preschool MH - Male MH - Female MH - *Body Mass Index MH - *Feeding Behavior/psychology MH - Cross-Sectional Studies MH - China MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - *Child Behavior MH - Factor Analysis, Statistical MH - East Asian People PMC - PMC11395637 OTO - NOTNLM OT - Body mass index OT - Children OT - Children's eating behavior questionnaire OT - Eating behaviors OT - Factorial validation COIS- The authors declare no competing interests. EDAT- 2024/09/13 00:46 MHDA- 2024/09/14 10:44 PMCR- 2024/09/12 CRDT- 2024/09/12 23:52 PHST- 2024/07/08 00:00 [received] PHST- 2024/08/29 00:00 [accepted] PHST- 2024/09/14 10:44 [medline] PHST- 2024/09/13 00:46 [pubmed] PHST- 2024/09/12 23:52 [entrez] PHST- 2024/09/12 00:00 [pmc-release] AID - 10.1186/s41043-024-00634-z [pii] AID - 634 [pii] AID - 10.1186/s41043-024-00634-z [doi] PST - epublish SO - J Health Popul Nutr. 2024 Sep 12;43(1):145. doi: 10.1186/s41043-024-00634-z. PMID- 39265552 OWN - NLM STAT- MEDLINE DCOM- 20241222 LR - 20260417 IS - 1662-4033 (Electronic) IS - 1662-4025 (Print) IS - 1662-4025 (Linking) VI - 17 IP - 6 DP - 2024 TI - Long-Term Change in BMI for Children with Obesity Treated in Family-Centered Lifestyle Interventions. PG - 570-581 LID - 10.1159/000540389 [doi] AB - INTRODUCTION: Several evaluations of lifestyle interventions for childhood obesity exist; however, follow-up beyond 2 years is necessary to validate the effect. The aim of the present study was to investigate long-term weight development following children participating in one of two pragmatic family-centered lifestyle interventions treating childhood obesity. METHODS: This real-life observational study included Danish children 4-17 years of age classified as having obesity. Data from 2010 to 2020, from two community-based family-centered lifestyle interventions (designated hereafter as the Aarhus- and the Randers-intervention) were merged with national registers and routine health check-ups, including height and weight. Adjusted mixed effect models were used to model changes in body mass index (BMI) z score. We performed exploratory analyses of the development in BMI z-score within stratified subgroups of children treated in the interventions before investigating potential effect modifications induced by sex, age, family structure, socioeconomic, or immigration status. RESULTS: With a median follow-up of 2.8 years (interquartile range: 1.3; 4.8), 703 children participated in an intervention (445 the Aarhus-intervention; 258 the Randers-intervention) and 2,337 children were not invited to participate (no-intervention). Children in both interventions experienced a comparable reduction in BMI z-scores during the first 6 months compared to the no-intervention group (Aarhus-intervention: -0.12 SD/year and Randers-intervention: -0.25 SD/year). Only children in the Randers-intervention reduced their BMI z-score throughout follow-up (Aarhus-intervention vs. no-intervention: 0.01 SD/year; confidence interval [CI]: -0.01; 0.04; Randers-intervention vs. no-intervention: -0.05 SD/year; CI: -0.08; -0.02). In subgroup comparisons, combining the two interventions, family income below the median (-0.05 SD/year, CI: -0.02; -0.09), immigrant background (0.04 SD/year, CI: 0.00; 0.07), or receiving intervention less than 1 year (0.04 SD/year, CI: 0.00; 0.08) were associated with a yearly increase in BMI z score. In addition, effect modification analyses did not observe any interaction by sex, age, family structure, socioeconomic, or immigration. CONCLUSIONS: Although the more dynamic intervention with longer duration obtained and sustained a minor reduction in BMI z score, the clinical impact may only be modest and still not effective enough to induce a long-term beneficial development in BMI in children with obesity. CI - (c) 2024 The Author(s). Published by S. Karger AG, Basel. FAU - Jorgensen, Rasmus Moller AU - Jorgensen RM AD - Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark. AD - Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. AD - Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark. AD - Danish National Center for Obesity, Aarhus, Denmark. FAU - Stovring, Henrik AU - Stovring H AD - Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark. AD - Department of Biomedicine, Aarhus University, Aarhus, Denmark. FAU - Ostergaard, Jane Nautrup AU - Ostergaard JN AD - Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark. FAU - Hede, Susanne AU - Hede S AD - Department of Children and Youth, Aarhus Municipality, Aarhus, Denmark. FAU - Svendsen, Katrine AU - Svendsen K AD - Department of Public Health, Aarhus University, Aarhus, Denmark. FAU - Vestergaard, Esben Thyssen AU - Vestergaard ET AD - Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark. AD - Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. AD - Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark. FAU - Bruun, Jens Meldgaard AU - Bruun JM AD - Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark. AD - Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. AD - Danish National Center for Obesity, Aarhus, Denmark. LA - eng PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20240912 PL - Switzerland TA - Obes Facts JT - Obesity facts JID - 101469429 SB - IM MH - Humans MH - *Body Mass Index MH - Child MH - *Pediatric Obesity/therapy MH - Male MH - Female MH - Adolescent MH - Denmark MH - Child, Preschool MH - Life Style MH - Follow-Up Studies PMC - PMC11662221 OTO - NOTNLM OT - Community-based OT - Lifestyle intervention OT - Long-term OT - Obesity OT - Trajectories COIS- R.M.J., H.S., J.N.O., E.T.V., and J.M.B. are employed at Steno Diabetes Center Aarhus, a public hospital and research institution situated in the Central Denmark Region, which is partly funded by an unrestricted grant from the Novo Nordisk Foundation. The remaining authors have no conflicts of interest to disclose. The Danish Regions and the Novo Nordisk Foundation had no role in the design and conduct of the study. EDAT- 2024/09/13 00:46 MHDA- 2024/12/23 00:19 PMCR- 2024/09/12 CRDT- 2024/09/12 18:23 PHST- 2023/12/13 00:00 [received] PHST- 2024/07/15 00:00 [accepted] PHST- 2024/12/23 00:19 [medline] PHST- 2024/09/13 00:46 [pubmed] PHST- 2024/09/12 18:23 [entrez] PHST- 2024/09/12 00:00 [pmc-release] AID - 000540389 [pii] AID - 540389 [pii] AID - 10.1159/000540389 [doi] PST - ppublish SO - Obes Facts. 2024;17(6):570-581. doi: 10.1159/000540389. Epub 2024 Sep 12. PMID- 39265255 OWN - NLM STAT- MEDLINE DCOM- 20241108 LR - 20260628 IS - 1873-2380 (Electronic) IS - 0021-9290 (Linking) VI - 176 DP - 2024 Nov TI - Repeatability of gait of children with spastic cerebral palsy in different walking conditions. PG - 112301 LID - S0021-9290(24)00379-8 [pii] LID - 10.1016/j.jbiomech.2024.112301 [doi] AB - Three-dimensional gait analysis is the 'gold standard' for measurement and description of gait. Gait variability can arise from intrinsic and extrinsic factors and may vary between walking conditions. This study aimed to define the inter-trial and inter-session repeatability in gait analysis data of children with cerebral palsy (CP) who were walking in four conditions, namely barefoot or with ankle-foot orthosis (AFO), and overground or treadmill. Ten children with spastic CP (7female symbol; 9.9y +/- 3.5y; GMFCS-level I-III) were included in this study. Overall, we found good to excellent intra-class correlation (ICC)-values and favourable standard error of measurement (SEM)-values for the inter-session Gait Profile Score (ICC = 0.85-0.98, SEM = 0.45-0.91 degrees ) and Gait Variable Scores (ICC = 0.85-0.99, SEM = 0.22-1.11 degrees ) for the lower-limb joints. Taking the total joint-range-of-motion into account, the knee joint showed the most repeatable motion (%SEM = 0.5-1.8 %), while ankle motions showed the lowest repeatability (%SEM = 0.8 %-3.0 %). For the continuous waveform data, only the ankle joint showed repeatability differences between walking conditions, namely, smaller SEM-values for the AFO-condition (mean inter-trial = 0.14 degrees ; mean inter-session = 1.121 degrees ) in comparison to the barefoot-condition (mean inter-trial = 0.55 degrees ; mean inter-session = 2.22 degrees ). For all the kinetic parameters, the treadmill conditions showed smaller SEM-values in comparison to the overground condition. In conclusion three-dimensional gait analysis was found to be reliable in all four walking conditions for children with CP. The resulting measurement errors can be used as a reference during clinical interpretations of gait analyses. Clinical trial registration number: Trial ID from an internationally recognized trial registry (ClinicalTrials.gov): NCT06355869. CI - Copyright (c) 2024 Elsevier Ltd. All rights reserved. FAU - Everaert, Laure AU - Everaert L AD - KU Leuven, Department of Rehabilitation Sciences, Leuven, Belgium; Clinical Motion Analysis Laboratory, University Hospitals Leuven, Leuven, Belgium. Electronic address: laure.everaert@kuleuven.be. FAU - Dewit, Tijl AU - Dewit T AD - KU Leuven, Department of Rehabilitation Sciences, Leuven, Belgium; Clinical Motion Analysis Laboratory, University Hospitals Leuven, Leuven, Belgium. FAU - Huenaerts, Catherine AU - Huenaerts C AD - Clinical Motion Analysis Laboratory, University Hospitals Leuven, Leuven, Belgium. FAU - Van Campenhout, Anja AU - Van Campenhout A AD - KU Leuven, Locomotor and Neurological Disorders, Department of Development and Regeneration, Leuven, Belgium; University Hospitals Leuven, Department of Orthopedics, Leuven, Belgium. FAU - Labey, Luc AU - Labey L AD - KU Leuven, Department of Mechanical Engineering, Geel, Belgium. FAU - Desloovere, Kaat AU - Desloovere K AD - KU Leuven, Department of Rehabilitation Sciences, Leuven, Belgium; Clinical Motion Analysis Laboratory, University Hospitals Leuven, Leuven, Belgium. LA - eng SI - ClinicalTrials.gov/NCT06355869 PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20240831 PL - United States TA - J Biomech JT - Journal of biomechanics JID - 0157375 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Ankle Joint/physiopathology MH - Biomechanical Phenomena MH - *Cerebral Palsy/physiopathology MH - *Gait/physiology MH - Gait Analysis/methods MH - Knee Joint/physiopathology MH - Range of Motion, Articular/physiology MH - Reproducibility of Results MH - *Walking/physiology OTO - NOTNLM OT - Cerebral palsy OT - Gait analysis OT - Rehabilitation OT - Variability COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/09/13 00:46 MHDA- 2024/11/13 13:53 CRDT- 2024/09/12 18:03 PHST- 2024/04/19 00:00 [received] PHST- 2024/08/07 00:00 [revised] PHST- 2024/08/30 00:00 [accepted] PHST- 2024/11/13 13:53 [medline] PHST- 2024/09/13 00:46 [pubmed] PHST- 2024/09/12 18:03 [entrez] AID - S0021-9290(24)00379-8 [pii] AID - 10.1016/j.jbiomech.2024.112301 [doi] PST - ppublish SO - J Biomech. 2024 Nov;176:112301. doi: 10.1016/j.jbiomech.2024.112301. Epub 2024 Aug 31. PMID- 39264915 OWN - NLM STAT- MEDLINE DCOM- 20240912 LR - 20261005 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 9 DP - 2024 TI - Psychometric evaluation of the Polish adaptation of the Body Appreciation Scale-2 for Children (BAS-2C). PG - e0309945 LID - 10.1371/journal.pone.0309945 [doi] LID - e0309945 AB - Positive body image is crucial in fostering self-esteem, mental well-being, and positive social functioning. However, our understanding of its development and role in school-aged children remains limited due to a scarcity of measures available for this age group across various countries and cultures. To bridge this gap, the aim of this study was to adapt the Body Appreciation Scale-2 for Children (BAS-2C) for Polish children aged 8-13 years. A total of 206 children completed BAS-2C to measure positive body image, the Figures Rating Scale to measure body satisfaction, and the Self-Perception Profile for Children to measure self-esteem. Parents provided information about their child's weight and height, which enabled analysis of a child's BMI. The results showed that the Polish version of BAS-2C exhibited a unidimensional factor structure, invariance across sex and age groups, and also provided evidence of very good internal consistency, test-retest reliability, and construct validity. BAS-2C scores were correlated positively with Figures Rating Scale, physical appearance and global self-esteem and were related negatively to age and BMI index, and weight group. Moreover, our research indicates that in older children, there are stronger correlations between positive body image and both global and physical appearance self-esteem, compared to younger children. The Polish version of BAS-2C has excellent psychometric properties and is appropriate for use with children aged 8-13 years. CI - Copyright: (c) 2024 Kubicka et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Kubicka, Karolina AU - Kubicka K AD - Faculty of Psychology, University of Warsaw, Warsaw, Poland. FAU - Trzcinska, Agata AU - Trzcinska A AUID- ORCID: 0000-0001-6640-5295 AD - Faculty of Psychology, University of Warsaw, Warsaw, Poland. FAU - Gambin, Malgorzata AU - Gambin M AUID- ORCID: 0000-0001-7880-1447 AD - Faculty of Psychology, University of Warsaw, Warsaw, Poland. LA - eng PT - Journal Article DEP - 20240912 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - Adolescent MH - *Psychometrics/methods MH - Poland MH - *Body Image/psychology MH - *Self Concept MH - Surveys and Questionnaires MH - Reproducibility of Results MH - Body Mass Index PMC - PMC11392422 COIS- The authors have declared that no competing interests exist. EDAT- 2024/09/12 19:50 MHDA- 2024/09/12 19:51 PMCR- 2024/09/12 CRDT- 2024/09/12 13:34 PHST- 2023/10/11 00:00 [received] PHST- 2024/08/21 00:00 [accepted] PHST- 2024/09/12 19:51 [medline] PHST- 2024/09/12 19:50 [pubmed] PHST- 2024/09/12 13:34 [entrez] PHST- 2024/09/12 00:00 [pmc-release] AID - PONE-D-23-31751 [pii] AID - 10.1371/journal.pone.0309945 [doi] PST - epublish SO - PLoS One. 2024 Sep 12;19(9):e0309945. doi: 10.1371/journal.pone.0309945. eCollection 2024. PMID- 39264400 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241018 IS - 2193-8210 (Print) IS - 2190-9172 (Electronic) VI - 14 IP - 10 DP - 2024 Oct TI - Cutaneous Manifestations in Patients with Dermatomyositis, Are They Only Skin Deep? PG - 2771-2785 LID - 10.1007/s13555-024-01266-1 [doi] AB - BACKGROUND: Dermatomyositis (DM) is a rare and severely debilitating autoimmune disease that can affect children and adults; however, there is little understanding of the patient-reported experience and uncertainty around validated clinical outcomes assessments (COAs) that could measure changes in the condition during clinical trials of new treatments. OBJECTIVES: The aim of this study was to understand the patient experience of DM, with a focus on its cutaneous manifestations, to describe the patient experience and determine the suitability of existing COA measures. METHODS: Adult (>/= 18 years) patients (N = 28) with severe active cutaneous manifestations of DM were interviewed. In the 90-min interviews, open-ended questions and probes were used to elicit descriptions of key clinical manifestations and patients' experiences of DM, including the symptoms and impacts on their daily lives and wellbeing. RESULTS: Patients reported 13 different skin manifestations of DM. The most common were rash (n = 28, 100%), itch (n = 28, 100%), dry skin (n = 23, 82%), and swelling of the skin (n = 17, 61%). The head and face, followed by hands, were perceived as the most bothersome body areas affected by skin manifestations, because they are exposed and visible to themselves and other people. All patients (n = 28, 100%) reported at least one impact of DM, which varied greatly between patients, but included emotional, psychological, cognitive, and physical impacts, and those affecting daily life, such as work and sleep. Over half of the patients (n = 19, 67%) reported that their daily activities were impacted by DM. CONCLUSIONS: The qualitative interviews with patients revealed that the presentation of DM manifestations is highly variable but affects patients' emotional wellbeing, physical activities, and daily life significantly. CI - (c) 2024. The Author(s). FAU - McKee, Stephanie AU - McKee S AD - Clinical Outcomes Assessment, Clarivate, London, UK. stephanie.mckee@clarivate.com. FAU - Xenakis, Jason AU - Xenakis J AD - Pfizer Inc, New York, USA. FAU - Makin, Harriet AU - Makin H AD - Clinical Outcomes Assessment, Clarivate, London, UK. FAU - Marshall, Chris AU - Marshall C AD - Clinical Outcomes Assessment, Clarivate, London, UK. FAU - Winnette, Randall AU - Winnette R AD - Pfizer Inc, New York, USA. stephanie.mckee@clarivate.com. FAU - Aggarwal, Rohit AU - Aggarwal R AD - University of Pittsburgh Medical Centre, Pittsburgh, USA. FAU - Knight, Sarah AU - Knight S AD - Clinical Outcomes Assessment, Clarivate, London, UK. LA - eng PT - Journal Article DEP - 20240912 PL - Switzerland TA - Dermatol Ther (Heidelb) JT - Dermatology and therapy JID - 101590450 PMC - PMC11480284 OTO - NOTNLM OT - Cutaneous manifestations OT - Dermatomyositis OT - Patient experience COIS- The study was funded by Pfizer Inc., and Jason Xenakis is an employee of Pfizer Inc. Randall Winnette, who is currently employed by Novartis, was also an employee at Pfizer Inc. when this research was conducted. The authors indicated no further potential conflicts of interest. Randall Winnette is a current employee of Novartis. This research was conducted when Randall Winnette was an employee at Pfizer Inc. EDAT- 2024/09/12 13:43 MHDA- 2024/09/12 13:44 PMCR- 2024/09/12 CRDT- 2024/09/12 11:04 PHST- 2024/07/18 00:00 [received] PHST- 2024/08/23 00:00 [accepted] PHST- 2024/09/12 13:44 [medline] PHST- 2024/09/12 13:43 [pubmed] PHST- 2024/09/12 11:04 [entrez] PHST- 2024/09/12 00:00 [pmc-release] AID - 10.1007/s13555-024-01266-1 [pii] AID - 1266 [pii] AID - 10.1007/s13555-024-01266-1 [doi] PST - ppublish SO - Dermatol Ther (Heidelb). 2024 Oct;14(10):2771-2785. doi: 10.1007/s13555-024-01266-1. Epub 2024 Sep 12. PMID- 39264046 OWN - NLM STAT- MEDLINE DCOM- 20240912 LR - 20250408 IS - 1945-7243 (Electronic) IS - 0046-9580 (Print) IS - 0046-9580 (Linking) VI - 61 DP - 2024 Jan-Dec TI - Validity and Reproducibility of a Culture-Specific Electronic Food Frequency Questionnaire: A Trinidad and Tobago Diet Assessment Study. PG - 469580241273247 LID - 10.1177/00469580241273247 [doi] LID - 00469580241273247 AB - Nutritional epidemiologists use culture-specific food frequency questionnaires (FFQs) to assess the dietary intake of groups based on country, region or ethnic groups. This study aimed to validate a culture-specific semi-quantitative electronic Food Frequency Questionnaire (e-FFQ) to estimate food group intake in the adult population of Trinidad and Tobago. A 139-item semi-quantitative e-FFQ containing local dishes and street food was administered twice to adults 18 years and older and compared against four 1-day food records (FRs) using digital photographs, which served as the reference method. The validity and reproducibility of the e-FFQ food group intake estimates were determined using paired t-tests, bivariate correlations, and cross-classifications. Reproducibility correlations between the reported food group intakes in the first and repeat administration of the e-FFQ ranged from moderate (r = .44, P /=2 (9/18) was higher than the proportion of TDCS >/=2 (5/18). As for the determination of pubertal onset, when UDCS was used as the gold standard, the specificity of PCS was 0.86 and positive predictive value was 90.00 %. CONCLUSIONS: There was a weak correlation between PCS and TDCS among girls early adolescence. Moreover, among overweight/obese girls, combining hormone values, ultrasonographic stage of breast, and the positive predictive value of PCS, we posit that self-reported PDS might be a more reliable method than TDCS to evaluate pubertal development among overweight/obese girls. CI - (c) 2024 Walter de Gruyter GmbH, Berlin/Boston. FAU - Lin, Cuilan AU - Lin C AD - Boai Hospital of Zhongshan, Zhongshan City, Guangdong Province, China. FAU - Pan, Dongxue AU - Pan D AD - Zhongshan Hospital of Sun-Yat-Sen University, Zhongshan City, Guangdong Province, China. FAU - Yu, Tingting AU - Yu T AD - Department of Clinical Epidemiology and Biostatistics, Children Health Advocacy Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Huang, Sizhe AU - Huang S AD - Health Care Center for Primary and Secondary Schools, Zhongshan City, Guangdong Province, China. FAU - Lai, Xin AU - Lai X AD - Zhongshan Hospital of Sun-Yat-Sen University, Zhongshan City, Guangdong Province, China. FAU - Peng, Jianming AU - Peng J AD - Boai Hospital of Zhongshan, Zhongshan City, Guangdong Province, China. FAU - Zhang, Bihong AU - Zhang B AD - Boai Hospital of Zhongshan, Zhongshan City, Guangdong Province, China. FAU - Liu, Shijian AU - Liu S AD - Department of Clinical Epidemiology and Biostatistics, Children Health Advocacy Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Fu, Simao AU - Fu S AD - Zhongshan Hospital of Sun-Yat-Sen University, Zhongshan City, Guangdong Province, China. LA - eng PT - Journal Article DEP - 20240913 PL - Germany TA - J Pediatr Endocrinol Metab JT - Journal of pediatric endocrinology & metabolism : JPEM JID - 9508900 SB - IM MH - Humans MH - Female MH - *Self Report MH - Child MH - *Puberty/physiology MH - Adolescent MH - Reproducibility of Results MH - China/epidemiology MH - Schools MH - Overweight/epidemiology MH - Surveys and Questionnaires MH - Prognosis MH - Body Mass Index MH - Follow-Up Studies OTO - NOTNLM OT - Tanner-derived composite stage OT - hormones levels OT - pubertal developmental scale OT - puberty category scores OT - ultrasound-derived composite stage EDAT- 2024/09/11 20:42 MHDA- 2024/10/09 12:25 CRDT- 2024/09/11 15:43 PHST- 2024/06/04 00:00 [received] PHST- 2024/08/16 00:00 [accepted] PHST- 2024/10/09 12:25 [medline] PHST- 2024/09/11 20:42 [pubmed] PHST- 2024/09/11 15:43 [entrez] AID - jpem-2024-0272 [pii] AID - 10.1515/jpem-2024-0272 [doi] PST - epublish SO - J Pediatr Endocrinol Metab. 2024 Sep 13;37(10):859-865. doi: 10.1515/jpem-2024-0272. Print 2024 Oct 28. PMID- 39259119 OWN - NLM STAT- MEDLINE DCOM- 20240911 LR - 20250503 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 103 IP - 22 DP - 2024 May 31 TI - Gastrointestinal bleeding in children with Henoch-Schonlein purpura combined with prognostic nutrition index may predict endoscopic duodenal ulcers during hospitalization: A single-center retrospective case-control study. PG - e38321 LID - 10.1097/MD.0000000000038321 [doi] LID - e38321 AB - Duodenal ulcer (DU) is the most common gastroscopic manifestation of abdominal Henoch-Schonlein purpura (HSP), which may cause severe bleeding and often requires esophagogastroduodenoscopy (EGD) to confirm the diagnosis. However, the condition of children with HSP changes rapidly; not all children are able to undergo EGD on time, and some hospitals do not have a pediatric EGD unit. Therefore, assessing the risk factors for developing DU in HSP using simple and readily available indicators is essential. Children with HSP at Wuhan Children Hospital from June 2020 to June 2022 were included in the training set and completed EGD. The patients were divided into 2 groups: those with (DU group) and without DU (non-DU group). Data were collected from the 2 groups, and univariate and multivariate logistic regression analyses were used to compare the 2 groups. Children with HSP admitted between July 2022 and June 2023 were included in the validation set. Four indicators, prognostic nutrition index, albumin (ALB), gastrointestinal (GI) bleeding, and duration of onset before EGD, were found in the DU and non-DU groups. GI bleeding and prognostic nutritional index (PNI) .05), trivial differences (dav = 0.00-0.16) were evident between trials in all tests. The coefficient of variation ranged from 0.05% to 4.02% across tests. The intraclass correlation ranged from .704 to .999. All tests presented relatively low standard error of measurement, with accompanying minimal detectable change provided. CONCLUSION: These data can help inform decision making among end-users when implementing tests in a repeated manner and interpreting testing data. FAU - Carron, Michael A AU - Carron MA AUID- ORCID: 0000-0002-8515-592X AD - School of Health, Medical and Applied Sciences, Central Queensland University, Rockhampton, QLD,Australia. AD - St. Brendan's College, Yeppoon, QLD,Australia. FAU - Scanlan, Aaron T AU - Scanlan AT AUID- ORCID: 0000-0002-0750-8697 AD - School of Health, Medical and Applied Sciences, Central Queensland University, Rockhampton, QLD,Australia. FAU - Doering, Thomas M AU - Doering TM AUID- ORCID: 0000-0002-6427-1067 AD - School of Health, Medical and Applied Sciences, Central Queensland University, Rockhampton, QLD,Australia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240906 PL - United States TA - Pediatr Exerc Sci JT - Pediatric exercise science JID - 8909729 SB - IM MH - Humans MH - Adolescent MH - *Football/physiology MH - Reproducibility of Results MH - *Exercise Test/methods MH - Male MH - *Physical Fitness/physiology MH - *Athletic Performance/physiology MH - Skinfold Thickness OTO - NOTNLM OT - evaluation OT - fitness OT - football OT - physiology OT - reproducibility EDAT- 2024/09/08 13:51 MHDA- 2025/07/15 18:27 CRDT- 2024/09/07 19:32 PHST- 2024/02/13 00:00 [received] PHST- 2024/05/10 00:00 [revised] PHST- 2024/05/23 00:00 [accepted] PHST- 2025/07/15 18:27 [medline] PHST- 2024/09/08 13:51 [pubmed] PHST- 2024/09/07 19:32 [entrez] AID - 10.1123/pes.2024-0031 [doi] PST - epublish SO - Pediatr Exerc Sci. 2024 Sep 6;37(3):212-219. doi: 10.1123/pes.2024-0031. Print 2025 Aug 1. PMID- 39243282 OWN - NLM STAT- MEDLINE DCOM- 20240907 LR - 20241019 IS - 1433-7339 (Electronic) IS - 0941-4355 (Print) IS - 0941-4355 (Linking) VI - 32 IP - 10 DP - 2024 Sep 7 TI - Survey of international pediatric nutritional supportive care practices: a report from the Pediatric Study Group of the Multinational Association of Supportive Care in Cancer (MASCC). PG - 644 LID - 10.1007/s00520-024-08826-3 [doi] LID - 644 AB - PURPOSE: Malnutrition is common in children with cancer. While multiple validated malnutrition screens exist, there is no universal, standardized approach to screen or diagnose malnutrition. The Multinational Association of Supportive Care in Cancer (MASCC) Pediatric Study Group is focused on oncologic supportive care for children and young adults. This subgroup designed and administered a pilot study to characterize global malnutrition screening, diagnosis, and treatment practices for pediatric patients with cancer after identifying variations in malnutrition practice patterns within its members. METHODS: A novel, exploratory survey was iteratively developed and distributed in early 2020 to 45 MASCC Pediatric Study Group members. The survey included multiple questions with standard patient presentations and nutritional scenarios, and the respondents selected the answer that best reflected the care patients would receive at their institution. RESULTS: A validated screening tool to assess for malnutrition was routinely used by 15 of 26 respondents (58%). No single validated screen was used by more than 24% of responders, and 11 of 26 (42%) reported not having a standard malnutrition treatment screen. When the same patient was presented with the survey using different malnutrition indicators, patient care plans varied greatly. This was particularly true for z-scores compared to weight percentiles. CONCLUSIONS: Development of consensus recommendations for screening practices, preferred malnutrition indicators, and treatment guidelines could help reduce the underdiagnosis of malnutrition and subsequent variation in its management and ought to be a focus of the global pediatric cancer supportive care community. CI - (c) 2024. The Author(s). FAU - Phillips, Charles A AU - Phillips CA AD - Division of Oncology, Children's Hospital of Philadelphia, 3500 Civic Center Boulevard, Philadelphia, PA, 19104, USA. AD - Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. AD - Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Kennelly, Regina AU - Kennelly R AD - Pediatrics Residency Program, Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Carroll, Catherine AU - Carroll C AD - National Children's Cancer Service, Children's Health Ireland, Dublin, Ireland. FAU - Gibson, Faith AU - Gibson F AD - School of Health Sciences, University of Surrey, Guildford, UK. AD - Centre for Outcomes and Experience Research in Children's Health, Illness and Disability, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. FAU - Elgarten, Caitlin W AU - Elgarten CW AD - Division of Oncology, Children's Hospital of Philadelphia, 3500 Civic Center Boulevard, Philadelphia, PA, 19104, USA. AD - Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. FAU - Orsey, Andrea AU - Orsey A AD - Center for Cancer and Blood Disorders, Connecticut Children's Medical Center, Hartford, CT, USA. AD - Department of Pediatrics, University of Connecticut School of Medicine, Farmington, CT, USA. FAU - Freedman, Jason L AU - Freedman JL AD - Division of Oncology, Children's Hospital of Philadelphia, 3500 Civic Center Boulevard, Philadelphia, PA, 19104, USA. freedmanj@chop.edu. AD - Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. freedmanj@chop.edu. LA - eng PT - Journal Article DEP - 20240907 PL - Germany TA - Support Care Cancer JT - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer JID - 9302957 SB - IM MH - Humans MH - *Neoplasms/complications/therapy MH - Child MH - *Malnutrition/diagnosis/therapy/etiology MH - Pilot Projects MH - *Nutritional Support/methods MH - Surveys and Questionnaires MH - Nutrition Assessment MH - Adolescent MH - Male MH - Practice Patterns, Physicians'/statistics & numerical data/standards MH - Female PMC - PMC11380636 OTO - NOTNLM OT - Malnutrition OT - Pediatric oncology OT - Undernutrition; Clinical nutrition; malnutrition; Pediatric oncology COIS- The authors declare no competing interests. EDAT- 2024/09/07 14:45 MHDA- 2024/09/07 14:46 PMCR- 2024/09/07 CRDT- 2024/09/07 11:02 PHST- 2024/01/09 00:00 [received] PHST- 2024/08/19 00:00 [accepted] PHST- 2024/09/07 14:46 [medline] PHST- 2024/09/07 14:45 [pubmed] PHST- 2024/09/07 11:02 [entrez] PHST- 2024/09/07 00:00 [pmc-release] AID - 10.1007/s00520-024-08826-3 [pii] AID - 8826 [pii] AID - 10.1007/s00520-024-08826-3 [doi] PST - epublish SO - Support Care Cancer. 2024 Sep 7;32(10):644. doi: 10.1007/s00520-024-08826-3. PMID- 39241463 OWN - NLM STAT- MEDLINE DCOM- 20240911 LR - 20250401 IS - 1878-5506 (Electronic) IS - 1389-9457 (Linking) VI - 123 DP - 2024 Nov TI - Exploring the Congruence of actigraphy and the Pediatric Autism Insomnia rating Scale. PG - 49-53 LID - S1389-9457(24)00400-3 [pii] LID - 10.1016/j.sleep.2024.08.029 [doi] AB - OBJECTIVE/BACKGROUND: Insomnia is common in children with autism spectrum disorder (ASD). We recently developed and validated the 21-item Pediatric Autism Insomnia Rating Scale (PAIRS). This report explores the associations and agreements between actigraphy and PAIRS. PARTICIPANTS METHODS: Children with ASD, with and without sleep problems, were assessed with a battery of parent-rated and clinician measures (N = 134). In a subset (n = 70), a wrist-worn actigraph measured sleep for five consecutive nights. Parents completed logs for scoring sleep intervals. Spearman correlations evaluated associations with the PAIRS and actigraphy indices (sleep onset latency = SOL, wake after sleep onset = WASO, total sleep time = TST, sleep efficiency = SE%). Agreements on "poor sleepers" based on PAIRS total score (>/=33) and conventional thresholds for TST and SE% were evaluated with Cohen's Kappa and McNemar's test. RESULTS: Actigraphy data were averaged over 4.64 +/- 0.68 nights in 70 children (mean age = 7.3 +/- 2.9, 74.3 % male). There were no significant correlations between PAIRS and any actigraphy indices. On TST, 48.6 % (n = 34) and on SE% 52.9 % (n = 37) were classified as "poor sleepers" compared to 32.9 % (n = 23) on PAIRS (kappa = 0.11 for TST and 0.27 for SE%). P-values on McNemar's Chi square test for PAIRS with TST and with SE% were 0.072 and 0.011, respectfully. CONCLUSIONS: These results suggest that actigraphy and PAIRS do not agree. Actigraphy TST captures movement and an estimate of specific sleep parameters. PAIRS is a broader measure that incorporates sleep disturbance and sleep-related impairment. CI - Copyright (c) 2024. Published by Elsevier B.V. FAU - Wenzell, Megan L AU - Wenzell ML AD - Case Western Reserve University Frances Payne Bolton School of Nursing, 9501 Euclid Ave, Cleveland, OH, 44106, USA. FAU - Johnson, Cynthia R AU - Johnson CR AD - Cleveland Clinic Children's Center for Autism, Lerner College of Medicine at Case Western Reserve University, 2801 Martin Luther King Jr. Dr., Cleveland, OH, 44104, USA. FAU - Lecavalier, Luc AU - Lecavalier L AD - The Ohio State University Nisonger Center and Department of Psychology, 1581 Dodd Drive, Columbus, OH, 43210, USA. FAU - Barto, Leah AU - Barto L AD - Cleveland Clinic Children's Center for Autism, Lerner College of Medicine at Case Western Reserve University, 2801 Martin Luther King Jr. Dr., Cleveland, OH, 44104, USA. FAU - Mulligan, Arielle AU - Mulligan A AD - The Ohio State University Nisonger Center, 1581 Dodd Drive, Columbus, OH, 43210, USA. FAU - Williams, Auscia AU - Williams A AD - Emory University School of Medicine, Marcus Autism Center, 1920 Briarcliff Rd. NE, Atlanta, GA, 30033, USA. FAU - Ousley, Opal AU - Ousley O AD - Emory University of Medicine, 2015 Uppergate Drive, Atlanta, GA, 30307, USA. FAU - Kim, Soo Youn AU - Kim SY AD - The Ohio State University Nisonger Center, 1581 Dodd Drive, Columbus, OH, 43210, USA; Nationwide Children's Hospital, 700 Childrens Drive, Columbus, OH, 43205, USA. FAU - Schiltz, Nicholas K AU - Schiltz NK AD - Case Western Reserve University Frances Payne Bolton School of Nursing, 9501 Euclid Ave, Cleveland, OH, 44106, USA. FAU - Scahill, Lawrence AU - Scahill L AD - Emory University School of Medicine, Marcus Autism Center, 1920 Briarcliff Rd. NE, Atlanta, GA, 30033, USA. Electronic address: Lawrence.scahill@emory.edu. LA - eng PT - Journal Article DEP - 20240830 PL - Netherlands TA - Sleep Med JT - Sleep medicine JID - 100898759 SB - IM MH - Humans MH - *Actigraphy/methods MH - Male MH - Female MH - Child MH - *Sleep Initiation and Maintenance Disorders/diagnosis MH - *Autism Spectrum Disorder/complications/diagnosis MH - Child, Preschool MH - Reproducibility of Results OTO - NOTNLM OT - Actigraphy OT - Autism spectrum disorder OT - Insomnia OT - Measure development COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests. Dr. Scahill has served as a consultant to Yamo Pharmaceuticals and Cogstate. He receives book royalties from Oxford, Guilford and American Psychological Association and license fees from Yamo, Roche and Abbvie. Dr. Lecavalier receives book royalties from Oxford and license fees from Yamo, Roche and Abbvie. Dr. Johnson receives book royalties from Oxford and American Psychological Association. The authors have no other financial interests to disclose. EDAT- 2024/09/07 14:42 MHDA- 2024/09/12 00:42 CRDT- 2024/09/06 18:05 PHST- 2024/04/17 00:00 [received] PHST- 2024/08/23 00:00 [revised] PHST- 2024/08/27 00:00 [accepted] PHST- 2024/09/12 00:42 [medline] PHST- 2024/09/07 14:42 [pubmed] PHST- 2024/09/06 18:05 [entrez] AID - S1389-9457(24)00400-3 [pii] AID - 10.1016/j.sleep.2024.08.029 [doi] PST - ppublish SO - Sleep Med. 2024 Nov;123:49-53. doi: 10.1016/j.sleep.2024.08.029. Epub 2024 Aug 30. PMID- 39241015 OWN - NLM STAT- MEDLINE DCOM- 20240906 LR - 20260923 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 9 DP - 2024 TI - Score of fear of COVID-19 and physical activity level are related to the habitual consumption of dietary supplements. PG - e0307870 LID - 10.1371/journal.pone.0307870 [doi] LID - e0307870 AB - The measures implemented to contain the COVID-19 pandemic resulted in both behavioral and lifestyle changes. The "Changes in Lifestyle-Related Behavior" instrument was developed to assess lifestyle-related behaviors in the Indian population. However, considering current knowledge, this instrument was not adapted for the Brazilian population. In addition, the relationship between fear of COVID-19 and consumption of dietary supplements has not yet been evaluated. Thus, we aimed to investigate the relationship between the use of dietary supplements with lifestyle behavior and the fear of COVID-19, as well as assess the psychometric properties of the Brazilian version of the "Changes in Lifestyle-Related Behavior" instrument. An online questionnaire assessed sociodemographic, occupational, anthropometric, physical activity (International Physical Activity Questionnaire-short form), fear of COVID-19, and lifestyle behavior data from 416 Brazilian adults (237 females; 18-60y). Mann-Whitney, Chi-square test, exploratory, and confirmatory analyses were applied. Exploratory and confirmatory analyses showed a satisfactory adequacy level of the questionnaire (CMIN/DF = 2.689; Cronbach's alpha = 0.60) with 5 domains ('Bad eating behavior'; 'Healthy eating'; 'Sleep quality'; 'Interest in cooking'; 'Number of portions and meals'). Lower fear of COVID-19 scores and higher levels of physical activity were found in participants who reported previous dietary supplement intake during the pandemic; in addition, the group that did not ingest dietary supplements reported greater changes in stress and anxiety levels during the pandemic (p<0.05). The intake of dietary supplements before the pandemic was associated with greater energy expenditure and better coping with the fear of COVID-19 during the pandemic. Additionally, the Changes in Lifestyle-Related Behavior tool can be used to assess lifestyle-related variables during the pandemic. CI - Copyright: (c) 2024 Tavares da Silva et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Tavares da Silva, Welligron AU - Tavares da Silva W AD - Health Sciences Department, Universidade Federal de Lavras (UFLA), Lavras, Brazil. FAU - Castelo, Paula Midori AU - Castelo PM AD - Department of Pharmaceutical Sciences, Universidade Federal de Sao Paulo (UNIFESP), Diadema, Brazil. FAU - Pereira, Luciano Jose AU - Pereira LJ AD - Health Sciences Department, Universidade Federal de Lavras (UFLA), Lavras, Brazil. FAU - Pardi, Vanessa AU - Pardi V AD - Department of Foundational Sciences, School of Dental Medicine, East Carolina University (ECU), Greenville, North Carolina, United States of America. FAU - Murata, Ramiro Mendonca AU - Murata RM AUID- ORCID: 0000-0002-8478-6981 AD - Department of Foundational Sciences, School of Dental Medicine, East Carolina University (ECU), Greenville, North Carolina, United States of America. FAU - Andrade, Eric Francelino AU - Andrade EF AUID- ORCID: 0000-0002-9253-3108 AD - Health Sciences Department, Universidade Federal de Lavras (UFLA), Lavras, Brazil. FAU - Pereira, Aline Carvalho AU - Pereira AC AD - Health Sciences Department, Universidade Federal de Lavras (UFLA), Lavras, Brazil. LA - eng SI - figshare/10.6084/m9.figshare.24718332 SI - figshare/10.6084/m9.figshare.24718356 PT - Journal Article DEP - 20240906 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *COVID-19/psychology/epidemiology MH - Female MH - *Exercise MH - Male MH - *Dietary Supplements MH - Adult MH - *Fear/psychology MH - Middle Aged MH - Surveys and Questionnaires MH - Brazil/epidemiology MH - Adolescent MH - Young Adult MH - SARS-CoV-2 MH - Life Style MH - Feeding Behavior/psychology MH - Pandemics MH - Psychometrics/methods PMC - PMC11379318 COIS- The authors have declared that no competing interests exist. EDAT- 2024/09/06 18:42 MHDA- 2024/09/06 18:43 PMCR- 2024/09/06 CRDT- 2024/09/06 14:03 PHST- 2023/05/23 00:00 [received] PHST- 2024/07/14 00:00 [accepted] PHST- 2024/09/06 18:43 [medline] PHST- 2024/09/06 18:42 [pubmed] PHST- 2024/09/06 14:03 [entrez] PHST- 2024/09/06 00:00 [pmc-release] AID - PONE-D-23-15162 [pii] AID - 10.1371/journal.pone.0307870 [doi] PST - epublish SO - PLoS One. 2024 Sep 6;19(9):e0307870. doi: 10.1371/journal.pone.0307870. eCollection 2024. PMID- 39240824 OWN - NLM STAT- MEDLINE DCOM- 20240906 LR - 20260923 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 9 DP - 2024 TI - Endoscopic treatment of obesity: A protocol of updated systematic review with network meta-analysis of randomized controlled trials. PG - e0308410 LID - 10.1371/journal.pone.0308410 [doi] LID - e0308410 AB - BACKGROUND: Obesity, characterized by excessive fat accumulation, poses a significant public health challenge globally. Recent advancements in medical technology have heralded the emergence of endoscopic bariatric treatments (EBTs) as innovative alternatives to conventional obesity interventions. Despite previous systematic reviews and network meta-analyses, they also highlighted discrepancies in outcomes and efficacy among different EBTs. Here, we will update a systematic review and network meta-analysis of randomized controlled trials (RCTs) focusing on EBTs and presents a protocol for the reproducibility and transparency. METHODS: The core protocol of this study was registered at PROSPERO database (CRD42024514249) on Jan 2024. Core databases including MEDLINE through PubMed, Embase, and Cochrane library will be searched relevant studies, and a systematic review with network meta-analysis will be performed. Two evaluators (EJ Gong and CS Bang) will independently screen the titles and abstracts following the eligibility criteria; (1) RCTs investigated the compared the efficacy of EBTs and controls; (2) studies published in English; and (3) studies in full-text format. We will exclude studies meeting the following criteria; (1) studies that did not report the treatment outcomes, such as percent excess weight loss or percent total body weight loss; (2) case reports and review articles; (3) ineligible research objects, for example, animals or children; and (4) insufficient data regarding treatment outcome. The primary outcomes will be the common efficacy metric found after systematic review of relevant studies, such as percent excess weight loss or percent total body weight loss with a follow-up of at least 6 months. Narrative (descriptive) synthesis is planned and quantitative synthesis will be used if the included studies are sufficiently homogenous. The quality of the identified studies will be assessed using the Cochrane Risk of Bias assessment tool version 2.0 (ROB 2.0). All the systematic review and network meta-analysis process will be undertaken keeping the principles of the Preferred Reporting Items for a Systematic Review and Meta-analysis for systematic review protocols (PRISMA-P) and PRISMA Extension Statement for Reporting of Systematic Reviews Incorporating Network Meta-analyses of Health Care Interventions (PRISMA-NMA). DISCUSSION: This updated systematic review and network meta-analysis will provide information about comparative efficacy of various EBTs and this will help physicians in the decision-making process for the selection of treatment modalities in the clinical practice. CI - Copyright: (c) 2024 Gong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Gong, Eun Jeong AU - Gong EJ AD - Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea. AD - Institute for Liver and Digestive Diseases, Hallym University, Chuncheon, Korea. AD - Institute of New Frontier Research, Hallym University College of Medicine, Chuncheon, Korea. FAU - Bang, Chang Seok AU - Bang CS AUID- ORCID: 0000-0003-4908-5431 AD - Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea. AD - Institute for Liver and Digestive Diseases, Hallym University, Chuncheon, Korea. AD - Institute of New Frontier Research, Hallym University College of Medicine, Chuncheon, Korea. FAU - Baik, Gwang Ho AU - Baik GH AD - Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea. AD - Institute for Liver and Digestive Diseases, Hallym University, Chuncheon, Korea. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240906 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Bariatric Surgery/methods MH - Endoscopy/methods MH - Network Meta-Analysis as Topic MH - *Obesity/surgery MH - Randomized Controlled Trials as Topic MH - Systematic Reviews as Topic MH - Treatment Outcome MH - Weight Loss PMC - PMC11379131 COIS- The authors have declared that no competing interests exist. EDAT- 2024/09/06 18:42 MHDA- 2024/09/06 18:43 PMCR- 2024/09/06 CRDT- 2024/09/06 13:33 PHST- 2024/04/03 00:00 [received] PHST- 2024/07/22 00:00 [accepted] PHST- 2024/09/06 18:43 [medline] PHST- 2024/09/06 18:42 [pubmed] PHST- 2024/09/06 13:33 [entrez] PHST- 2024/09/06 00:00 [pmc-release] AID - PONE-D-24-11942 [pii] AID - 10.1371/journal.pone.0308410 [doi] PST - epublish SO - PLoS One. 2024 Sep 6;19(9):e0308410. doi: 10.1371/journal.pone.0308410. eCollection 2024. PMID- 39239929 OWN - NLM STAT- MEDLINE DCOM- 20240911 LR - 20240927 IS - 1896-494X (Electronic) IS - 1232-1087 (Print) IS - 1232-1087 (Linking) VI - 37 IP - 3 DP - 2024 Sep 10 TI - Exhaled volatile organic compounds (VOCs) for prediction of asthma exacerbation in children. PG - 351-359 LID - 191400 [pii] LID - 10.13075/ijomeh.1896.02442 [doi] AB - OBJECTIVES: To find possible relationship between asthma exacerbation and metabolomic profile of airways, assessed by non-invasive method - free volatile organic compounds (VOCs) in exhaled air in children. MATERIAL AND METHODS: The study included 80 children aged 4-18 years with asthma: 42 children with a min. 3 asthma exacerbations in the past 12 months, and 38 children without a history of exacerbations in the past year. During the study visit, each patient was examined, medical history (including information regarding atopy and eosinophil blood count) was taken, spirometry and fractional exhaled nitric oxide (FeNO) were tested, an exhaled air sample was taken to test for the presence of VOCs, and the patient also completed standardized form - Asthma Control Questionnaire. Volatile organic compounds were measured by combined gas chromatography coupled to mass spectrometry. RESULTS: The obtained results of VOCs were correlated with the history of the disease. The 2 gas profiles were defined and they formed 2 clinically distinct clusters (p = 0.085). Cluster 2 was characterized for children with a higher number of bronchial asthma exacerbations and worse lung function parameters (predicted percentage forced expiratory volume in 1 s [FEV(1)] [p = 0.023], FEV(1)/ forced vital capacity ratio [FVC] [p = 0.0219]). The results were independent of the age, sex, BMI, atopy (house dust mite allergy) and eosinophil blood count. CONCLUSIONS: The study findings suggest that a relative group of gases may be a useful predictor of having asthma exacerbations in children. Additionally, a single FeNO value was unlikely to be clinically useful in predicting asthma exacerbations in children. The VOCs profile reflecting the metabolism of the airway epithelium and local microbiota was associated with the course of asthma, which strongly justifies further prospective validation studies. Int J Occup Med Environ Health. 2024;37(3):351-59. CI - This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license. FAU - Gmachowska, Katarzyna AU - Gmachowska K AD - Medical University of Lodz, Lodz, Poland (Department of Pediatric and Allergy). AD - Copernicus Hospital, Lodz, Poland (Department of Pediatric and Allergy, Korczak Pediatric Center). FAU - Podlecka, Daniela AU - Podlecka D AD - Medical University of Lodz, Lodz, Poland (Department of Pediatric and Allergy). AD - Copernicus Hospital, Lodz, Poland (Department of Pediatric and Allergy, Korczak Pediatric Center). FAU - Bonikowski, Radoslaw AU - Bonikowski R AD - Lodz University of Technology, Lodz, Poland (Institute of Natural Products and Cosmetics). FAU - Majak, Pawel AU - Majak P AD - Copernicus Hospital, Lodz, Poland (Department of Pediatric and Allergy, Korczak Pediatric Center). AD - Medical University of Lodz, Lodz, Poland (Department of Pediatric Pulmonology). FAU - Kapka, Karolina AU - Kapka K AD - Copernicus Hospital, Lodz, Poland (Department of Pediatric and Allergy, Korczak Pediatric Center). FAU - Jerzynska, Joanna AU - Jerzynska J AD - Medical University of Lodz, Lodz, Poland (Department of Pediatric and Allergy). AD - Copernicus Hospital, Lodz, Poland (Department of Pediatric and Allergy, Korczak Pediatric Center). LA - eng PT - Journal Article DEP - 20240904 PL - Poland TA - Int J Occup Med Environ Health JT - International journal of occupational medicine and environmental health JID - 9437093 RN - 0 (Volatile Organic Compounds) SB - IM MH - Humans MH - *Asthma/physiopathology/diagnosis MH - Child MH - *Volatile Organic Compounds/analysis MH - Male MH - Female MH - Adolescent MH - Child, Preschool MH - *Breath Tests MH - Exhalation MH - Spirometry PMC - PMC11424151 OTO - NOTNLM OT - VOCs OT - asthma OT - asthma monitoring OT - atopy OT - children OT - lung function tests EDAT- 2024/09/06 12:43 MHDA- 2024/09/11 12:46 PMCR- 2024/01/01 CRDT- 2024/09/06 07:33 PHST- 2024/09/11 12:46 [medline] PHST- 2024/09/06 12:43 [pubmed] PHST- 2024/09/06 07:33 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - 191400 [pii] AID - ijomeh.1896.02442 [pii] AID - 10.13075/ijomeh.1896.02442 [doi] PST - ppublish SO - Int J Occup Med Environ Health. 2024 Sep 10;37(3):351-359. doi: 10.13075/ijomeh.1896.02442. Epub 2024 Sep 4. PMID- 39237278 OWN - NLM STAT- MEDLINE DCOM- 20240905 LR - 20250206 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 14 IP - 9 DP - 2024 Sep 5 TI - Demographic and surgical characteristics in patients who do not achieve minimal important change in the KOOS Sport/Rec and QoL after ACL reconstruction: a comparative study from the Swedish National Knee Ligament Registry. PG - e083803 LID - 10.1136/bmjopen-2023-083803 [doi] LID - e083803 AB - OBJECTIVES: This study aimed to compare demographic and surgical characteristics between patients who do and do not achieve minimal important change (MIC) in the Knee injury and Osteoarthritis Outcome Score (KOOS) Sports and Recreation (Sport/Rec) and Quality of Life (QoL) subscales 1 year after anterior cruciate ligament reconstruction. DESIGN: Comparative cross-sectional. SETTING: The MIC for the KOOS Sport/Rec subscale was >/=12.1 and >/=18.3 for the KOOS QoL subscale from before surgery to 1-year follow-up using data from the Swedish National Knee Ligament Registry. PARTICIPANTS: In total 16 131 patients were included: 11 172 (69%) with no MIC for the Sport/Rec scale, and 10 641 (66%) for the QoL. RESULTS: Patients with no MIC for Sport/Rec and QoL had a higher body mass index (BMI) (24.8+/-3.5 vs 24.6+/-3.3 and 24.7+/-3.5 vs 24.6+/-3.2, respectively, p<0.0001), were younger (years) at time of surgery (28.5+/-10.3 vs 29.1+/-10.8 and 27.4+/-9.8 vs 29.7+/-11.0, respectively, p=0.0002 and <0.0001), had longer time from injury to surgery (months) (Sports/Rec 22.0+/-38.5 vs 19.3+/-36.6, respectively, p=0.0002), and greater rates of concomitant cartilage injuries especially to the lateral femoral condyle (22.7% vs 19.4% and 23.3% vs 19.0%, respectively, p=0.001 and p=0.005) compared with patients who achieved the MIC. A smaller proportion of patients treated with a hamstring tendon autograft had no MIC (91.4%) compared with patients with MIC (94.1%). CONCLUSIONS: Patients with no MIC for KOOS Sport/Rec and QoL subscales had a higher BMI, longer time from injury to surgery and were younger at the time of surgery compared with patients who did achieve MIC. Although differences were small, they may reframe management strategies with patients who have these characteristics. CI - (c) Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Simonsson, Rebecca AU - Simonsson R AUID- ORCID: 0000-0001-7025-7619 AD - University of Gothenburg, Goteborg, Sweden rebecca.simonsson@gu.se. FAU - Bittar, Judy AU - Bittar J AD - Department of Orthopaedics, University of Gothenburg, Goteborg, Sweden. FAU - Kaarre, Janina AU - Kaarre J AUID- ORCID: 0000-0003-2559-8283 AD - Department of Orthopaedics, Medical sciences, Goteborg, Sweden. FAU - Zsidai, Balint AU - Zsidai B AUID- ORCID: 0000-0002-5697-6577 AD - Department of Orthopaedics, Medical sciences, Goteborg, Sweden. FAU - Sansone, Mikael AU - Sansone M AD - Ortopedi, Sahlgrenska Academy, Goteborg, Sweden. FAU - Piussi, Ramana AU - Piussi R AD - University of Gothenburg, Goteborg, Sweden. AD - Sahlgrenska Sports Medicine Center, Gothenburg, Sweden. FAU - Musahl, Volker AU - Musahl V AD - Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Irrgang, James AU - Irrgang J AD - University of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Samuelsson, Kristian AU - Samuelsson K AD - Sahlgrenska University Hospital, Gothenburg, Sweden. FAU - Senorski, Eric Hamrin AU - Senorski EH AUID- ORCID: 0000-0002-9340-0147 AD - University of Gothenburg, Goteborg, Sweden. AD - Neuroscience and physiology, Health and rehabilitation, Goteborg, Sweden. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240905 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Anterior Cruciate Ligament Reconstruction MH - Male MH - Female MH - *Quality of Life MH - Adult MH - Sweden MH - *Registries MH - Cross-Sectional Studies MH - *Anterior Cruciate Ligament Injuries/surgery MH - Young Adult MH - Middle Aged MH - Treatment Outcome MH - Return to Sport MH - Adolescent PMC - PMC11381709 OTO - NOTNLM OT - Knee OT - Musculoskeletal disorders OT - Orthopaedic sports trauma OT - Psychometrics OT - REGISTRIES OT - SPORTS MEDICINE COIS- Competing interests: JI is President-Elect of the Board of Directors for the Journal of Orthopaedic and Sports Physical Therapy. VM reports educational grants, consulting fees and speaking fees from Smith & Nephew, educational grants from Arthrex and DePuy/Synthes, is a board member of the International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine (ISAKOS) and deputy editor-in-chief of Knee Surgery, Sports Traumatology, Arthroscopy (KSSTA). KS is a board member at Getinge AB. EHS is the associate editor of Journal of Orthopeadic and Sports Physical Therapy. EDAT- 2024/09/06 01:02 MHDA- 2024/09/06 01:03 PMCR- 2024/09/05 CRDT- 2024/09/05 21:13 PHST- 2024/09/06 01:03 [medline] PHST- 2024/09/06 01:02 [pubmed] PHST- 2024/09/05 21:13 [entrez] PHST- 2024/09/05 00:00 [pmc-release] AID - bmjopen-2023-083803 [pii] AID - 10.1136/bmjopen-2023-083803 [doi] PST - epublish SO - BMJ Open. 2024 Sep 5;14(9):e083803. doi: 10.1136/bmjopen-2023-083803. PMID- 39237268 OWN - NLM STAT- MEDLINE DCOM- 20240905 LR - 20240911 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 8 IP - 1 DP - 2024 Sep 4 TI - Tanner's target height formula underestimates final adult height in Korean adolescents and young adults: reassessment of target height based on the Korean National Health and Nutrition Examination Survey 2010-2019. LID - 10.1136/bmjpo-2024-002653 [doi] LID - e002653 AB - OBJECTIVE: Estimating children's target height (TH) plays an important role in diagnosing, evaluating and treating many paediatric endocrinological diseases. However, in many countries, employing Tanner's formula to predict children's final adult height (FAH) is considered misleading. Therefore, this study aimed to re-evaluate the validity of Tanner's formula for predicting the TH of Korean adolescents and young adults and develop a new formula suitable for Korean children. DESIGN/SETTING: Data were derived from the Korean National Health and Nutrition Examination Survey 2010-2019. PATIENTS: A total of 2586 participants (1266 men, 1320 women) were included, excluding participants for whom Tanner's formula could not be calculated because of missing parental height data. MAIN OUTCOME MEASURES: Tanner-based TH was compared with the FAH. RESULTS: The difference between Tanner-based TH and FAH was 4.86+/-0.178 cm for men and 4.81+/-0.150 cm for women. Sex-specific univariable and multivariable analyses were conducted to determine variables influencing positive height gap (greater than estimated TH). Both men and women with higher education levels were more likely to exhibit a positive height gap. Those with a history of chronic illness were less likely to exhibit a positive height gap, particularly in women. Using a new formula derived using linear regression analysis, the sum of parental heights explained 27.6% and 30.6% of the variance in sons' and daughters' heights, respectively. CONCLUSIONS: Tanner's formula for calculating TH tended to underestimate FAH; hence, our new formula may offer a better alternative for estimating TH and evaluating growth in Korean children and adolescents. CI - (c) Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Kim, Sejin AU - Kim S AUID- ORCID: 0000-0002-5974-5109 AD - Department of Pediatrics, Dong-A University College of Medicine, Busan, Busan, Korea (the Republic of). FAU - Yoo, Jae Ho AU - Yoo JH AD - Department of Pediatrics, Dong-A University College of Medicine, Busan, Busan, Korea (the Republic of). FAU - Chueh, Hee Won AU - Chueh HW AUID- ORCID: 0000-0002-3824-2334 AD - Department of Pediatrics, Inje University Haeundae Paik Hospital, Busan, Busan, Korea (the Republic of) caaf80@empal.com. LA - eng PT - Journal Article DEP - 20240904 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Male MH - Female MH - Republic of Korea MH - Adolescent MH - *Body Height MH - *Nutrition Surveys MH - Young Adult PMC - PMC11381647 OTO - NOTNLM OT - Adolescent Health OT - Growth COIS- Competing interests: No potential conflict of interest relevant to this article was reported. EDAT- 2024/09/06 01:02 MHDA- 2024/09/06 01:03 PMCR- 2024/09/04 CRDT- 2024/09/05 21:12 PHST- 2024/05/26 00:00 [received] PHST- 2024/08/16 00:00 [accepted] PHST- 2024/09/06 01:03 [medline] PHST- 2024/09/06 01:02 [pubmed] PHST- 2024/09/05 21:12 [entrez] PHST- 2024/09/04 00:00 [pmc-release] AID - 10.1136/bmjpo-2024-002653 [pii] AID - bmjpo-2024-002653 [pii] AID - 10.1136/bmjpo-2024-002653 [doi] PST - epublish SO - BMJ Paediatr Open. 2024 Sep 4;8(1):e002653. doi: 10.1136/bmjpo-2024-002653. PMID- 39236080 OWN - NLM STAT- MEDLINE DCOM- 20241007 LR - 20260923 IS - 1613-9860 (Electronic) IS - 1869-6716 (Print) IS - 1613-9860 (Linking) VI - 14 IP - 10 DP - 2024 Oct 6 TI - Comparison of Researcher-Led versus Teacher-Led effectiveness and fidelity: A Hybrid Type 1 study of Kids SIPsmartER in Appalachia middle schools. PG - 578-587 LID - 10.1093/tbm/ibae041 [doi] AB - The implementation of school-based obesity-prevention programs is understudied. Kids SIPsmartER is a 6-month, school-based, behavioral intervention for Appalachian middle school students and includes a teacher implementation strategy. Kids SIPsmartER effectively reduced students' sugar-sweetened beverages (SSB) when Researcher-Led. However, Teacher-Led effectiveness and fidelity are unknown. To explore the relative SSB effects when Kids SIPsmartER was Researcher-Led versus Teacher-Led and to examine teacher fidelity. This study of secondary outcomes used a quasi-experimental analytic approach of a Hybrid Type 1 effectiveness-implementation and cluster randomized controlled tria (RCT) of Kids SIPsmartER. Student SSB behaviors and teacher self-rated fidelity were assessed, respectively, with the validated Beverage Intake Questionnaire (BEVQ-15) and lesson-specific checklists. Analyses included descriptive statistics and modified two-part models with time-fixed effects and school-year cohort cluster controls. The analytic sample included students from six control schools (n = 220), six Researcher-Led intervention schools (n = 306), and five Teacher-Led intervention schools (n = 218), as well as eight teachers. Teacher-Led intervention students decreased SSB by -14.3 ounces/day (95% confidence interval = -15.4, -13.2; P < .001). Relative to control and to Researcher-Led intervention, the Teacher-Led treatment effect among students was -11.6 ounces SSB/day (P < .001, effect size = 0.75) and -4.3 (P = .004, effect size = 0.25), respectively. Teachers returned fidelity checklists for 90% of planned lessons. Fidelity averaged 94% (SD = 4.0%) among returned forms and 85% (SD = 18.9%) when missing forms were counted as zeros. Teachers can implement Kids SIPsmartER with high fidelity and produce statistically and clinically meaningful improvements in students' SSB behaviors. Findings have implications for the sustained implementation of Kids SIPsmartER and other school-based obesity-prevention programs. Clinical Trial information: NCT03740113. CI - (c) Society of Behavioral Medicine 2024. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Zoellner, Jamie M AU - Zoellner JM AUID- ORCID: 0000-0001-5445-5594 AD - Department of Public Health Sciences, University of Virginia (UVA), UVA Cancer Center Research and Outreach Office, Christiansburg, VA, USA. FAU - Porter, Kathleen J AU - Porter KJ AD - Department of Public Health Sciences, University of Virginia (UVA), UVA Cancer Center Research and Outreach Office, Christiansburg, VA, USA. FAU - Reid, Annie AU - Reid A AD - Department of Public Health Sciences, University of Virginia (UVA), UVA Cancer Center Research and Outreach Office, Christiansburg, VA, USA. FAU - Markwalter, Theresa AU - Markwalter T AD - Department of Public Health Sciences, University of Virginia (UVA), UVA Cancer Center Research and Outreach Office, Christiansburg, VA, USA. FAU - Kirkpatrick, Brittany AU - Kirkpatrick B AD - Department of Public Health Sciences, University of Virginia (UVA), UVA Cancer Center Research and Outreach Office, Christiansburg, VA, USA. FAU - Brock, Donna-Jean P AU - Brock DP AD - Department of Public Health Sciences, University of Virginia (UVA), UVA Cancer Center Research and Outreach Office, Christiansburg, VA, USA. FAU - You, Wen AU - You W AD - Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA. LA - eng SI - ClinicalTrials.gov/NCT03740113 GR - R01 MD012603/MD/NIMHD NIH HHS/United States GR - R01MD012603/MD/NIMHD NIH HHS/United States GR - NH/NIH HHS/United States PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, N.I.H., Extramural PL - England TA - Transl Behav Med JT - Translational behavioral medicine JID - 101554668 SB - IM MH - Humans MH - Female MH - Male MH - *School Teachers/psychology MH - Child MH - Appalachian Region MH - *School Health Services MH - Adolescent MH - *Pediatric Obesity/prevention & control MH - *Students/psychology MH - Schools MH - Sugar-Sweetened Beverages MH - Research Personnel MH - Health Promotion/methods PMC - PMC11456871 OAB - Numerous evidence-based behavioral interventions related to obesity prevention have been established in schools, yet relatively few have been replicated or successfully implemented by teachers. Kids SIPsmartER is a school-based, behavioral intervention for Appalachian middle school students that effectively reduced students' sugar-sweetened beverages (SSB) when delivered by researchers. This study describes the implementation strategies bundle for teachers. The purpose of this study was to explore SSB effects among students when Kids SIPsmartER was delivered by teachers versus delivered by researchers and relative to control students. Teacher fidelity to the program was also examined. Students decreased their SSB more when teachers delivered Kids SIPsmartER, compared with when the researcher delivered the program and to control students. Teachers also taught the intervention with high program fidelity. In sum, teachers can implement Kids SIPsmartER with high fidelity and can produce meaningful improvements in students' SSB behaviors. Findings have implications for the sustained implementation of Kids SIPsmartER among teachers as well as for other school-based programs. OABL- eng OTO - NOTNLM OT - adolescence OT - hybrid design OT - implementation OT - rural population OT - schools OT - sugar-sweetened beverages EDAT- 2024/09/05 18:42 MHDA- 2024/10/07 12:57 PMCR- 2025/09/05 CRDT- 2024/09/05 13:43 PHST- 2024/10/07 12:57 [medline] PHST- 2024/09/05 18:42 [pubmed] PHST- 2024/09/05 13:43 [entrez] PHST- 2025/09/05 00:00 [pmc-release] AID - 7749934 [pii] AID - ibae041 [pii] AID - 10.1093/tbm/ibae041 [doi] PST - ppublish SO - Transl Behav Med. 2024 Oct 6;14(10):578-587. doi: 10.1093/tbm/ibae041. PMID- 39236041 OWN - NLM STAT- MEDLINE DCOM- 20240905 LR - 20260923 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 9 DP - 2024 TI - Metabolic syndrome predictive modelling in Bangladesh applying machine learning approach. PG - e0309869 LID - 10.1371/journal.pone.0309869 [doi] LID - e0309869 AB - Metabolic syndrome (MetS) is a cluster of interconnected metabolic risk factors, including abdominal obesity, high blood pressure, and elevated fasting blood glucose levels, that result in an increased risk of heart disease and stroke. In this research, we aim to identify the risk factors that have an impact on MetS in the Bangladeshi population. Subsequently, we intend to construct predictive machine learning (ML) models and ultimately, assess the accuracy and reliability of these models. In this particular study, we utilized the ATP III criteria as the basis for evaluating various health parameters from a dataset comprising 8185 participants in Bangladesh. After employing multiple ML algorithms, we identified that 27.8% of the population exhibited a prevalence of MetS. The prevalence of MetS was higher among females, accounting for 58.3% of the cases, compared to males with a prevalence of 41.7%. Initially, we identified the crucial variables using Chi-Square and Random Forest techniques. Subsequently, the obtained optimal variables are employed to train various models including Decision Trees, Random Forests, Support Vector Machines, Extreme Gradient Boosting, K-nearest neighbors, and Logistic Regression. Particularly we employed the ATP III criteria, which utilizes the Waist-to-Height Ratio (WHtR) as an anthropometric index for diagnosing abdominal obesity. Our analysis indicated that Age, SBP, WHtR, FBG, WC, DBP, marital status, HC, TGs, and smoking emerged as the most significant factors when using Chi-Square and Random Forest analyses. However, further investigation is necessary to evaluate its precision as a classification tool and to improve the accuracy of all classifiers for MetS prediction. CI - Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. FAU - Hossain, Md Farhad AU - Hossain MF AUID- ORCID: 0000-0002-3105-5915 AD - Division of Computing, Analytics and Mathematics, Department of Mathematics and Statistics, School of Science and Engineering, University of Missouri, Kansas City, MO, United States of America. AD - Department of Statistics, Comilla University, Cumilla, Bangladesh. FAU - Hossain, Shaheed AU - Hossain S AD - Department of Statistics, Comilla University, Cumilla, Bangladesh. FAU - Akter, Mst Nira AU - Akter MN AD - Department of Statistics, Comilla University, Cumilla, Bangladesh. FAU - Nahar, Ainur AU - Nahar A AD - Department of Statistics, Comilla University, Cumilla, Bangladesh. FAU - Liu, Bowen AU - Liu B AUID- ORCID: 0000-0002-6918-9871 AD - Division of Computing, Analytics and Mathematics, Department of Mathematics and Statistics, School of Science and Engineering, University of Missouri, Kansas City, MO, United States of America. FAU - Faruque, Md Omar AU - Faruque MO AD - Division of Energy, Matter and Sciences, School of Science and Engineering, University of Missouri, Kansas City, MO, United States of America. LA - eng SI - Dryad/10.5061/dryad.zkh18937f PT - Journal Article DEP - 20240905 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Metabolic Syndrome/epidemiology/diagnosis MH - Bangladesh/epidemiology MH - Male MH - Female MH - *Machine Learning MH - Adult MH - Middle Aged MH - Risk Factors MH - Prevalence MH - Young Adult MH - Aged MH - Adolescent MH - Obesity, Abdominal/epidemiology/diagnosis PMC - PMC11376561 COIS- There is no conflict of interest among the authors. EDAT- 2024/09/05 18:42 MHDA- 2024/09/05 18:43 PMCR- 2024/09/05 CRDT- 2024/09/05 13:34 PHST- 2024/02/15 00:00 [received] PHST- 2024/08/12 00:00 [accepted] PHST- 2024/09/05 18:43 [medline] PHST- 2024/09/05 18:42 [pubmed] PHST- 2024/09/05 13:34 [entrez] PHST- 2024/09/05 00:00 [pmc-release] AID - PONE-D-24-05709 [pii] AID - 10.1371/journal.pone.0309869 [doi] PST - epublish SO - PLoS One. 2024 Sep 5;19(9):e0309869. doi: 10.1371/journal.pone.0309869. eCollection 2024. PMID- 39235762 OWN - NLM STAT- MEDLINE DCOM- 20240926 LR - 20240926 IS - 1751-8431 (Electronic) IS - 1751-8423 (Linking) VI - 27 IP - 7 DP - 2024 Oct TI - The oral behavior screener: a brief caregiver-completed measure of oral behaviors. PG - 228-234 LID - 10.1080/17518423.2024.2398765 [doi] AB - INTRODUCTION: To date, there are no caregiver-reported screening measures of oral behaviors related to feeding. The goal of this study was to develop such a measure. METHOD: Caregivers of 803 children referred to a feeding clinic and 188 comparison children reported their children's frequency of nine oral behaviors. These data were used to develop an Oral Behavior Screener (OBS). Both the psychometrics of the OBS and the relations between the OBS and child demographics were examined. RESULTS: As expected, the clinical sample demonstrated more deficits in oral behaviors than the comparison sample. We also found special needs status and age were linked to the OBS summary score. DISCUSSION: The OBS is a brief screener that can be used by clinicians to examine the need for further assessment, possible targets for intervention, oral behaviors often associated with feeding problems. FAU - Williams, Keith E AU - Williams KE AUID- ORCID: 0000-0002-6762-4585 AD - Pediatrics, Penn State Hershey Medical Center, Hershey, PA, USA. FAU - Adams, Whitney AU - Adams W AD - Pediatrics, Penn State Hershey Medical Center, Hershey, PA, USA. FAU - Riegel, Katherine AU - Riegel K AD - Pediatrics, Penn State Hershey Medical Center, Hershey, PA, USA. FAU - Massare, Brittany AU - Massare B AD - Pediatrics, Penn State Hershey Medical Center, Hershey, PA, USA. FAU - Hendy, Helen AU - Hendy H AD - Psychology, Penn State Schuylkill, Schuylkill Haven, PA, USA. FAU - Dailey, Scott AU - Dailey S AD - Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. LA - eng PT - Journal Article DEP - 20240905 PL - England TA - Dev Neurorehabil JT - Developmental neurorehabilitation JID - 101304394 SB - IM MH - Humans MH - Female MH - Male MH - Child, Preschool MH - *Caregivers MH - *Psychometrics MH - Child MH - Feeding Behavior MH - Infant MH - Adolescent OTO - NOTNLM OT - Developmental disorders OT - feeding problems OT - oral motor OT - special needs EDAT- 2024/09/05 12:44 MHDA- 2024/09/26 19:03 CRDT- 2024/09/05 11:23 PHST- 2024/09/26 19:03 [medline] PHST- 2024/09/05 12:44 [pubmed] PHST- 2024/09/05 11:23 [entrez] AID - 10.1080/17518423.2024.2398765 [doi] PST - ppublish SO - Dev Neurorehabil. 2024 Oct;27(7):228-234. doi: 10.1080/17518423.2024.2398765. Epub 2024 Sep 5. PMID- 39234293 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240907 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 11 DP - 2024 TI - A report card assessment of the prevalence of healthy eating among preschool-aged children: a cross-cultural study across Australia, Hong Kong, Singapore, and the US. PG - 1428852 LID - 10.3389/fnut.2024.1428852 [doi] LID - 1428852 AB - OBJECTIVE: This study aimed to initially adopt an International Healthy Eating Report Card for Preschool-Aged Children to assess the prevalence of healthy eating behaviours and favourable family home food environments (FHFEs) among preschool-aged children in Australia, Hong Kong, Singapore, and the US. We also examined which cultural contexts would exhibit significant differences in the report card scores among the four cultural contexts. METHODS: In this cross-cultural study, 2059 parent-child dyads, with approximately 500 dyads in each cultural context, were recruited. The parents were asked to complete the validated International Healthy Eating Report Card Scale to assess the dimensions of the Report Card [i.e., Indicator of Children's Eating Behaviours: (1) Children's Dietary Patterns and (2) Children's Mealtime Behaviours, and Indicator of FHFEs: (3) Parental Food Choices and Preparation, (4) Home Healthier Food Availability and Accessibility and (5) Family Mealtime Environments]. Each indicator received a letter grade [i.e., A (>/=80%) = excellent, B (60-79%) = good, C (40-59%) = fair, D (20-39%) = poor, F (<20%) = very poor and including the plus (+) and minus (-) signs] to represent the proportion of participants who could meet the predefined benchmarks. We also employed ANCOVA and Bonferroni's post-hoc test to examine the differences in the report card scores between the four cultural contexts. A significance level was set at p < 0.05. RESULTS: The average overall report card grade across the four cultural contexts was "B-" (Good), ranging from "C+" (Singapore and the US) to "B-" (Australia and Hong Kong). The average grade for Children's Eating Behaviours was classified as Fair ("C-"), while the average grade for FHFEs was classified as Good ("B+") for all cultural contexts. A comparison of the overall report card scores revealed that Australia exhibited a significantly higher report card score than Singapore and the US, while Hong Kong achieved a significantly higher score than Singapore. CONCLUSION: The International Healthy Eating Report Card provided an overview of the prevalence of healthy eating in different cultural contexts. We believe that the International Healthy Eating Report Card may offer new perspectives on interventions for fostering healthy eating in young children. CI - Copyright (c) 2024 Wan, Chung, Li, Xu and Chan. FAU - Wan, Alison Wing Lam AU - Wan AWL AD - Department of Early Childhood Education, The Education University of Hong Kong, Hong Kong, Hong Kong SAR, China. FAU - Chung, Kevin Kien Hoa AU - Chung KKH AD - Department of Early Childhood Education, The Education University of Hong Kong, Hong Kong, Hong Kong SAR, China. FAU - Li, Jian-Bin AU - Li JB AD - Department of Early Childhood Education, The Education University of Hong Kong, Hong Kong, Hong Kong SAR, China. FAU - Xu, Shebe Siwei AU - Xu SS AD - Department of Early Childhood Education, The Education University of Hong Kong, Hong Kong, Hong Kong SAR, China. FAU - Chan, Derwin King Chung AU - Chan DKC AD - Department of Early Childhood Education, The Education University of Hong Kong, Hong Kong, Hong Kong SAR, China. LA - eng PT - Journal Article DEP - 20240821 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC11371745 OTO - NOTNLM OT - eating behaviours OT - family home food environment OT - healthy eating OT - obesity OT - preschool-aged children OT - prevalence OT - report card COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/09/05 06:42 MHDA- 2024/09/05 06:43 PMCR- 2024/01/01 CRDT- 2024/09/05 04:22 PHST- 2024/05/07 00:00 [received] PHST- 2024/08/12 00:00 [accepted] PHST- 2024/09/05 06:43 [medline] PHST- 2024/09/05 06:42 [pubmed] PHST- 2024/09/05 04:22 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - 10.3389/fnut.2024.1428852 [doi] PST - epublish SO - Front Nutr. 2024 Aug 21;11:1428852. doi: 10.3389/fnut.2024.1428852. eCollection 2024. PMID- 39233877 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240907 IS - 1179-5514 (Print) IS - 1179-5514 (Electronic) IS - 1179-5514 (Linking) VI - 17 DP - 2024 TI - Prevalence and Predictors of Diabetic Retinopathy, Its Progression and Regression in Indian Children and Youth With Type-1 Diabetes. PG - 11795514241275921 LID - 10.1177/11795514241275921 [doi] LID - 11795514241275921 AB - OBJECTIVE: There are very few reports on the prevalence of diabetic retinopathy (DR) in children and youth with type-1 diabetes (T1D). Studies have also found very low rates of referral for DR screening in children and youth with T1D. We conducted this study to determine the prevalence of DR, to study the reliability of ISPAD screening recommendations and to identify predictors of DR, its progression and regression in Indian children and youth with T1D. METHODS: This study included 882 children and youth with T1D. Demographic data, anthropometry, blood pressure, sexual maturity rating, ophthalmological examination (slit lamp for cataract) and biochemical measurements were performed using standard protocols. Fundus images were captured using the Forus Health 3netra classic digital non-mydriatic fundus camera by the same experienced operator. De-identified images were assessed by a senior grader and ophthalmologist (Belfast Ophthalmic Reading Center). Severity of DR was graded as per the UK National Health Service (NHS) DR classification scale. RESULT: We report 6.4% and 0.2% prevalence of DR and cataract in Indian children and youth with T1D, respectively. All the subjects with DR had early non-proliferative DR. We report that amongst subjects with DR, only 2 subjects were aged less than 11 years and had duration of illness less than 2 years. Presence of hypertension and older age were significant predictors of DR (P < .05). Subjects with DR had significantly higher triglyceride concentrations (P < .05), of these, 6.9% had progression and 2.9% had regression at 1 year follow up; the change in glycaemic control was a significant positive predictor of progression of DR (P < .05). None of the participants included in the study progressed to develop sight-threatening DR. CONCLUSION: DR is not uncommon in Indian children and youth with T1D, thus screening for DR needs to be initiated early, particularly in older individuals with higher disease duration. Controlling blood pressure and triglyceride concentrations may prevent occurrence of DR. Improving glycaemic control may prevent progression of DR in Indian children and youth with T1D. CI - (c) The Author(s) 2024. FAU - Oza, Chirantap AU - Oza C AD - Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India. FAU - Khadilkar, Anuradha AU - Khadilkar A AUID- ORCID: 0000-0002-3399-3235 AD - Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India. FAU - Bhor, Shital AU - Bhor S AD - Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India. FAU - Curran, Katie AU - Curran K AUID- ORCID: 0000-0002-7071-109X AD - Centre for Public Health, Queen's University Belfast, Northern Ireland. FAU - Sambare, Chitra AU - Sambare C AD - Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India. FAU - Ladkat, Dipali AU - Ladkat D AD - Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India. FAU - Bettiol, Alessandra AU - Bettiol A AD - Department of Experimental and Clinical Medicine, University of Florence, Italy. FAU - Quinn, Michael AU - Quinn M AD - Centre for Public Health, Queen's University Belfast, Northern Ireland. FAU - Sproule, Alan AU - Sproule A AD - Centre for Public Health, Queen's University Belfast, Northern Ireland. FAU - Willoughby, Colin AU - Willoughby C AD - Genomic Medicine, Biomedical Sciences Research Institute, Ulster University, Coleraine, Northern Ireland, UK. FAU - Peto, Tunde AU - Peto T AD - Centre for Public Health, Queen's University Belfast, Northern Ireland. LA - eng PT - Journal Article DEP - 20240902 PL - United States TA - Clin Med Insights Endocrinol Diabetes JT - Clinical medicine insights. Endocrinology and diabetes JID - 101578235 PMC - PMC11372767 OAB - Diabetic retinopathy in Indian children with Type 1 Diabetes We found that 6.4% and 0.2% Indian children and youth with type-1 diabetes had diabetic retinopathy and cataract respectively. We report that amongst subjects with DR, only 2 subjects were aged less than 11 years and had duration of illness less than 2 years. Thus, International Society for Paediatric and Adolescent Diabetes (ISPAD) screening criteria must be implemented by all centres to avoid missing cases. Presence of high blood pressure, high triglyceride levels and older age were significant predictors of DR. Of the subjects with DR, 6.9% had progression and 2.9% had regression at 1 year follow up; the change in glycaemic control was a significant positive predictor of progression of DR. None of the participants included in the study progressed to develop sight-threatening DR. DR is not uncommon in Indian children and youth with T1D, hence, screening for DR needs to be initiated early, particularly in older individuals with higher disease duration. Controlling blood pressure and triglyceride concentrations may prevent occurrence of DR. Improving glycaemic control may prevent progression of DR in Indian children and youth with T1D. OABL- eng OTO - NOTNLM OT - Type-1 diabetes OT - children OT - progression OT - regression OT - retinopathy COIS- The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2024/09/05 06:42 MHDA- 2024/09/05 06:43 PMCR- 2024/09/02 CRDT- 2024/09/05 04:16 PHST- 2024/03/04 00:00 [received] PHST- 2024/08/01 00:00 [accepted] PHST- 2024/09/05 06:43 [medline] PHST- 2024/09/05 06:42 [pubmed] PHST- 2024/09/05 04:16 [entrez] PHST- 2024/09/02 00:00 [pmc-release] AID - 10.1177_11795514241275921 [pii] AID - 10.1177/11795514241275921 [doi] PST - epublish SO - Clin Med Insights Endocrinol Diabetes. 2024 Sep 2;17:11795514241275921. doi: 10.1177/11795514241275921. eCollection 2024. PMID- 39233117 OWN - NLM STAT- MEDLINE DCOM- 20241213 LR - 20260402 IS - 1097-6833 (Electronic) IS - 0022-3476 (Linking) VI - 276 DP - 2025 Jan TI - Predictive Validity of the Academy of Nutrition and Dietetics/American Society for Parental Nutrition Indicators to Diagnose Malnutrition and the Screening Tool for Risk on Nutritional Status and Growth among Hospitalized Children Relative to Medical Outcomes. PG - 114288 LID - S0022-3476(24)00391-3 [pii] LID - 10.1016/j.jpeds.2024.114288 [doi] AB - OBJECTIVE: To evaluate predictive validity of the Academy of Nutrition and Dietetics/American Society for Parenteral and Enteral Nutrition Indicators to diagnose pediatric malnutrition (AAIMp) and the Screening Tool for Risk on Nutritional Status and Growth (STRONGkids) in regard to pediatric patient outcomes in US hospitals. STUDY DESIGN: A prospective cohort study (Clinical Trial Registry: NCT03928548) was completed from August 2019 through January 2023 with 27 pediatric hospitals or units from 18 US states and Washington DC. RESULTS: Three hundred and forty-five children were enrolled in the cohort (n = 188 in the AAIMp validation subgroup). There were no significant differences in the incidence of emergency department visits and hospital readmissions, hospital length of stay (LOS), or health care resource utilization for children diagnosed with mild, moderate, or severe malnutrition using the AAIMp tool compared with children with no malnutrition diagnosis. The STRONGkids tool significantly predicted more emergency department visits and hospital readmissions for children at moderate and high malnutrition risk (moderate risk - incidence rate ratio 1.65, 95% CI: 1.09, 2.49, P = .018; high risk - incidence rate ratio 1.64, 95% CI: 1.05, 2.56, P = .028) and longer LOS (43.8% longer LOS, 95% CI: 5.2%, 96.6%, P = .023) for children at high risk compared with children at low risk after adjusting for patient characteristics. CONCLUSIONS: Malnutrition risk based on the STRONGkids tool predicted poor medical outcomes in hospitalized US children; the same relationship was not observed for a malnutrition diagnosis based on the AAIMp tool. CI - Copyright (c) 2024 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Jimenez, Elizabeth Yakes AU - Jimenez EY AD - Department of Research, International, and Scientific Affairs, Academy of Nutrition and Dietetics, Chicago, IL; Epidemiology Concentration, College of Population Health, University of New Mexico Health Sciences Center, Albuquerque, NM; Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM; Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM. FAU - Lamers-Johnson, Erin AU - Lamers-Johnson E AD - Department of Research, International, and Scientific Affairs, Academy of Nutrition and Dietetics, Chicago, IL. Electronic address: elamersjohnson@eatright.org. FAU - Long, Julie M AU - Long JM AD - Department of Research, International, and Scientific Affairs, Academy of Nutrition and Dietetics, Chicago, IL. FAU - Woodcock, Lindsay AU - Woodcock L AD - Department of Research, International, and Scientific Affairs, Academy of Nutrition and Dietetics, Chicago, IL. FAU - Bliss, Courtney AU - Bliss C AD - Department of Research, International, and Scientific Affairs, Academy of Nutrition and Dietetics, Chicago, IL. FAU - Steiber, Alison L AU - Steiber AL AD - Department of Research, International, and Scientific Affairs, Academy of Nutrition and Dietetics, Chicago, IL. LA - eng PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20240902 PL - United States TA - J Pediatr JT - The Journal of pediatrics JID - 0375410 SB - IM MH - Humans MH - Female MH - Male MH - Child, Preschool MH - Prospective Studies MH - Child MH - *Nutritional Status MH - Infant MH - United States MH - *Nutrition Assessment MH - Child, Hospitalized/statistics & numerical data MH - Length of Stay/statistics & numerical data MH - Child Nutrition Disorders/diagnosis/epidemiology MH - Patient Readmission/statistics & numerical data MH - Risk Assessment MH - Malnutrition/diagnosis/epidemiology MH - Hospitalization/statistics & numerical data MH - Reproducibility of Results MH - Predictive Value of Tests OTO - NOTNLM OT - child malnutrition OT - hospital readmission OT - length of stay OT - nutrition assessment OT - pediatric hospitals OT - validation study COIS- Declaration of Competing Interest This study was funded by the Academy of Nutrition and Dietetics Foundation, the Commission on Dietetic Registration, the Pediatric Nutrition Practice Group, the Clinical Nutrition Management Dietetic Practice Group, and the Renal Dietitians Practice Group. E.L.J., L.W., and A.S. are employed by the Academy of Nutrition and Dietetics, which supported the consensus process for developing the Academy of Nutrition and Dietetics/American Society for Parenteral and Enteral Nutrition tool for diagnosing malnutrition in hospitalized pediatric patients. E.Y.J., J.L., and C.B. all received contract funding from the Academy of Nutrition and Dietetics and/or the Academy of Nutrition and Dietetics Foundation for work performed for the study. Study sponsors gave input on the study design and data interpretation via the study advisory committee but were not involved in the collection and analysis of data, writing the manuscript, or the decision to submit the manuscript for publication. EDAT- 2024/09/05 06:42 MHDA- 2024/12/14 00:24 CRDT- 2024/09/05 00:10 PHST- 2024/04/30 00:00 [received] PHST- 2024/08/26 00:00 [revised] PHST- 2024/08/27 00:00 [accepted] PHST- 2024/12/14 00:24 [medline] PHST- 2024/09/05 06:42 [pubmed] PHST- 2024/09/05 00:10 [entrez] AID - S0022-3476(24)00391-3 [pii] AID - 10.1016/j.jpeds.2024.114288 [doi] PST - ppublish SO - J Pediatr. 2025 Jan;276:114288. doi: 10.1016/j.jpeds.2024.114288. Epub 2024 Sep 2. PMID- 39232776 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240907 IS - 1743-7075 (Print) IS - 1743-7075 (Electronic) IS - 1743-7075 (Linking) VI - 21 IP - 1 DP - 2024 Sep 4 TI - Prospective associations between an empirically derived dietary pattern and life satisfaction in Malaysian adolescents. PG - 71 LID - 10.1186/s12986-024-00832-w [doi] LID - 71 AB - BACKGROUND: Little is known on the prospective associations between an empirically derived dietary pattern (DP) and life satisfaction among adolescents. This PUTRA-Adol follow-up study aimed to assess the prospective associations between the empirically derived DP and life satisfaction during adolescence. METHODS: A total of 585 and 262 adolescents participated in the baseline PUTRA-Adol study in 2016 and PUTRA-Adol follow-up study in 2019-2020, respectively. These adolescents were recruited from three southern states in peninsular Malaysia, namely Negeri Sembilan, Melaka and Johor. Dietary assessments were estimated using a validated food frequency questionnaire (FFQ) while a Multidimensional Students' Life Satisfaction Scale (MSLSS) was used to measure life satisfaction at baseline in 2016 as well as at follow-up in 2019-2020. A DP characterised by foods high in free sugar and energy dense was identified using reduced rank regression (RRR), cross-sectionally at baseline and was reported elsewhere. Similar RRR analysis was used to find a DP that best explained the variation in response variables linked to poorer life satisfaction, including dietary energy density (DED), fiber density, and percentage of energy from total fat and sugar at the PUTRA-Adol follow-up study. Prospective relationship between adherence to the identified DPs and overall life satisfaction scores as well as its domains between 2016 and 2019-2020 were evaluated using generalized estimating equation models (GEE). RESULTS: A DP characterized by high intakes of percentage energy from sugar, fibre and low in DED and percentage energy from total fat was identified at the 2019-2020 follow-up. The identified DP explained 11% of total variations in the response variables and was characterized by high intakes of sweets, sugar sweetened beverages (SSB) and fruits. Female adolescents [67.6(8.9)] had a mean (SD) of life satisfaction that was higher than male adolescents [67.5(10.8)] p < 0.05 in 2019-2020. Prospective analysis found a significant positive association between the identified DP and school domain, in male adolescents (beta = 0.117; 95% CI 0.001, 0.234) and an inverse relationship between the DP z-score and self-domain in all adolescents (beta = - 0.060; 95% CI - 0.115, - 0.005) from 2016 to 2019-2020. CONCLUSIONS: An increasing score for the predominant 'High sugar and High fibre' DP was prospectively associated with increasing life satisfaction score for the school domain in male adolescents and decreasing score for self-domain in both male and females during adolescence. A lifestyle intervention targeting reduced dietary intakes, particularly sugar, may improve life satisfaction in adolescents and promote healthier future without compromising dietary intakes for chronic disease prevention later in life. CI - (c) 2024. The Author(s). FAU - Magendiran, Mugambikai AU - Magendiran M AD - Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), 43400, Selangor, Malaysia. FAU - Appannah, Geeta AU - Appannah G AD - Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), 43400, Selangor, Malaysia. geeta@upm.edu.my. FAU - Emi, Nor Aishah AU - Emi NA AD - Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), 43400, Selangor, Malaysia. FAU - Chin, Yit Siew AU - Chin YS AD - Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), 43400, Selangor, Malaysia. FAU - Shariff, Zalilah Mohd AU - Shariff ZM AD - Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), 43400, Selangor, Malaysia. FAU - Anuar Zaini, Azriyanti AU - Anuar Zaini A AD - Department of Paediatrics, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. FAU - Shamsuddin, Nurainul Hana AU - Shamsuddin NH AD - Department of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), 43400, Selangor, Malaysia. FAU - Suppiah, Subapriya AU - Suppiah S AD - Department of Radiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), 43400, Selangor, Malaysia. FAU - Saini, Suraini Mohamad AU - Saini SM AD - Department of Radiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), 43400, Selangor, Malaysia. FAU - Thambiah, Subashini C AU - Thambiah SC AD - Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), 43400, Selangor, Malaysia. FAU - Ching, Siew Mooi AU - Ching SM AD - Department of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), 43400, Selangor, Malaysia. LA - eng PT - Journal Article DEP - 20240904 PL - England TA - Nutr Metab (Lond) JT - Nutrition & metabolism JID - 101231644 PMC - PMC11376057 OTO - NOTNLM OT - Adolescence OT - Dietary patterns OT - Life satisfaction OT - Malaysia OT - PUTRA-Adol OT - Tracking COIS- The authors declare no competing interests. EDAT- 2024/09/05 06:42 MHDA- 2024/09/05 06:43 PMCR- 2024/09/04 CRDT- 2024/09/05 00:01 PHST- 2023/11/30 00:00 [received] PHST- 2024/07/22 00:00 [accepted] PHST- 2024/09/05 06:43 [medline] PHST- 2024/09/05 06:42 [pubmed] PHST- 2024/09/05 00:01 [entrez] PHST- 2024/09/04 00:00 [pmc-release] AID - 10.1186/s12986-024-00832-w [pii] AID - 832 [pii] AID - 10.1186/s12986-024-00832-w [doi] PST - epublish SO - Nutr Metab (Lond). 2024 Sep 4;21(1):71. doi: 10.1186/s12986-024-00832-w. PMID- 39232052 OWN - NLM STAT- MEDLINE DCOM- 20240904 LR - 20240907 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Sep 4 TI - Construction and validation of nomogram to predict surgical site infection after hysterectomy: a retrospective study. PG - 20538 LID - 10.1038/s41598-024-71592-z [doi] LID - 20538 AB - This study aimed to develop a predictive tool for surgical site infections (SSI) following hysterectomy and propose strategies for their prevention and control. We conducted a retrospective analysis at a tertiary maternity and child specialist hospital in Zhejiang Province, focusing on patients who underwent hysterectomy between January 2018 and December 2023 for gynecological malignancies or benign reproductive system diseases resistant to medical treatment. Risk factors associated with surgical site infections (SSI) following hysterectomy were identified using LASSO regression analysis on data from 2018 to 2022 as the training set. Independent risk factors were then used to develop a nomogram. The model was validated using data from 2023 as the validation set. Model performance was assessed using the area under the receiver operating characteristic curve (ROC), while calibration curves were employed to gauge model accuracy. Furthermore, clinical utility was evaluated through clinical decision curve analysis (DCA) and clinical impact curve analysis (CIC), providing insights into the practical application of the nomogram. Multivariate analysis identified six independent risk factors associated with SSI development after hysterectomy: BMI >/= 24 kg/m(2) (OR: 2.58; 95% CI 1.14-6.19; P < 0.05), hypoproteinaemia diagnosis (OR: 4.99; 95% CI 1.95-13.02; P < 0.05), postoperative antibiotic use for >/= 3 days (OR: 49.53; 95% CI 9.73-91.01; P < 0.05), history of previous abdominal surgery (OR: 7.46; 95% CI 2.93-20.01; P < 0.05), hospital stay >/= 10 days (OR: 9.67; 95% CI 2.06-76.46; P < 0.05), and malignant pathological type (OR: 4.62; 95% CI 1.78-12.76; P < 0.05). A nomogram model was constructed using these variables. ROC and calibration curves demonstrated good model calibration and discrimination in both training and validation sets. Analysis with DCA and CIC confirmed the clinical utility of the nomogram. Personalized nomogram mapping for SSI after hysterectomy enables early identification of high-risk patients, facilitating timely interventions to reduce SSI incidence post-surgery. CI - (c) 2024. The Author(s). FAU - Shao, Hui AU - Shao H AD - Department of Infectology, Shaoxing Maternity and ChildHealth Care Hospital, Shaoxing, China. FAU - Wang, Xiujuan AU - Wang X AD - Department of Infectology, Shaoxing Maternity and ChildHealth Care Hospital, Shaoxing, China. FAU - Feng, Lili AU - Feng L AD - Department of Anesthesiology, Shaoxing Maternity and ChildHealth Care Hospital, Shaoxing, China. fenglili19850310@163.com. LA - eng PT - Journal Article PT - Validation Study DEP - 20240904 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Hysterectomy/adverse effects MH - *Nomograms MH - Female MH - Retrospective Studies MH - *Surgical Wound Infection/diagnosis/etiology/epidemiology MH - Middle Aged MH - Risk Factors MH - Adult MH - ROC Curve MH - Aged PMC - PMC11375043 OTO - NOTNLM OT - Hospital-acquired infection OT - Hysterectomy OT - LASSO regression OT - Surgical site infection COIS- The authors declare no competing interests. EDAT- 2024/09/05 00:49 MHDA- 2024/09/05 00:50 PMCR- 2024/09/04 CRDT- 2024/09/04 23:32 PHST- 2023/12/25 00:00 [received] PHST- 2024/08/29 00:00 [accepted] PHST- 2024/09/05 00:50 [medline] PHST- 2024/09/05 00:49 [pubmed] PHST- 2024/09/04 23:32 [entrez] PHST- 2024/09/04 00:00 [pmc-release] AID - 10.1038/s41598-024-71592-z [pii] AID - 71592 [pii] AID - 10.1038/s41598-024-71592-z [doi] PST - epublish SO - Sci Rep. 2024 Sep 4;14(1):20538. doi: 10.1038/s41598-024-71592-z. PMID- 39231101 OWN - NLM STAT- MEDLINE DCOM- 20240904 LR - 20260918 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 9 DP - 2024 TI - Influence of non-directional errors in anthropometric measurements and age estimation on anthropometric prevalence indicators. PG - e0304131 LID - 10.1371/journal.pone.0304131 [doi] LID - e0304131 AB - Anthropometric prevalence indicators such as stunting, wasting, and underweight are widely-used population-level tools used to track trends in childhood nutrition. Threats to the validity of these data can lead to erroneous decision making and improper allocation of finite resources intended to support some of the world's most vulnerable populations. It has been demonstrated previously that aggregated prevalence rates for these indicators can be highly sensitive to biases in the presence of non-directional measurement errors, but the quantitative relationship between the contributing factors and the scale of this bias has not been fully described. In this work, a Monte Carlo simulation exercise was performed to generate high-statistics z-score distributions with a wide range of mean and standard deviation parameters relevant to the populations in low- and middle-income countries (LMIC). With the important assumption that the distribution's standard deviation should be close to 1.0 in the absence of non-directional measurement errors, the shift in prevalence rate due to this common challenge is calculated and explored. Assuming access to a given z-score distribution's mean and standard deviation values, this relationship can be used to evaluate the potential scale of prevalence bias for both historical and modern anthropometric indicator results. As a demonstration of the efficacy of this exercise, the bias scale for a set of 21 child anthropometry datasets collected in LMIC contexts is presented. CI - Copyright: (c) 2024 Grange et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Grange, Joseph M AU - Grange JM AUID- ORCID: 0000-0002-8069-9610 AD - United States Agency for International Development, Washington, D.C, United States of America. AD - Environmental Incentives, South Lake Tahoe, California, United States of America. FAU - Mock, Nancy B AU - Mock NB AD - School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, United States of America. FAU - Collins, Shalean M AU - Collins SM AD - School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, United States of America. LA - eng PT - Journal Article DEP - 20240904 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Anthropometry/methods MH - Prevalence MH - Child, Preschool MH - Infant MH - Monte Carlo Method MH - Child MH - Male MH - Female MH - Bias MH - Growth Disorders/epidemiology MH - Thinness/epidemiology PMC - PMC11373794 COIS- The authors have declared that no competing interests exist. EDAT- 2024/09/04 18:42 MHDA- 2024/09/04 18:43 PMCR- 2024/09/04 CRDT- 2024/09/04 13:23 PHST- 2023/11/08 00:00 [received] PHST- 2024/05/07 00:00 [accepted] PHST- 2024/09/04 18:43 [medline] PHST- 2024/09/04 18:42 [pubmed] PHST- 2024/09/04 13:23 [entrez] PHST- 2024/09/04 00:00 [pmc-release] AID - PONE-D-23-25689 [pii] AID - 10.1371/journal.pone.0304131 [doi] PST - epublish SO - PLoS One. 2024 Sep 4;19(9):e0304131. doi: 10.1371/journal.pone.0304131. eCollection 2024. PMID- 39229983 OWN - NLM STAT- MEDLINE DCOM- 20250219 LR - 20250514 IS - 1875-5550 (Electronic) IS - 1389-2037 (Linking) VI - 26 IP - 2 DP - 2025 TI - Comparative Study of Lactogenic Effect and Milk Nutritional Density of Oral Galactagogue in Female Rabbit. PG - 125-138 LID - 10.2174/0113892037300581240830052536 [doi] AB - BACKGROUND: Hypogalactia and agalactia in lactating mothers are the major causes of child malnutrition, mortality, morbidity, and overall ill health. The development of such treatments requires a well-designed preclinical study with suitable laboratory animals, which needs to be improved. Thus, a suitably designed study with a laboratory animal to analyse galactagogue activity, along with an assessment of the quality and quantity of milk, is required. OBJECTIVES: This study aimed to evaluate the potential of rabbit as an animal model for studying lactogenic activity. METHODS: The structural homology of prolactin, gene prolactin receptor, and prolactin hormone in humans, rabbit, and rat was studied using BLAST and PyMol to assess similarity in the lactogenic system. Daily and cumulative milk production and pre-treatment (control) and post-treatment (three drugs) in rabbits were recorded and evaluated by analysing protein, fat, lactose, solid non-- fat, and ash values. All parameters were recorded on the 0th day and at the end of weeks 1, 2, and 3. Mammary gland histopathology was performed to evaluate the effects on mammary glands. RESULTS: Homology studies revealed that the sequences of the human and rabbit prolactin genes, receptors, and hormones had a high similarity index. Treatment with Domperidone, Metoclopramide, and Shatavari significantly enhanced milk production by enhancing prolactin secretion; only Shatavari increased milk nutrition. Enlargement of the tubuloalveolar ducts of the mammary glands was observed. CONCLUSION: Our findings suggest that rabbits are robust, reproducible, ethically superior, and preclinically relevant animals for assessing lactogenic activity. CI - Copyright(c) Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. FAU - Maru, Saurabh AU - Maru S AD - School of Pharmacy and Technology Management, SVKM's NMIMS, Babulde, Banks of Tapi River, Mumbai-Agra Road, Shirpur, Maharashtra 425405, India. AD - Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM'S NMIMS, V.L. Mehta Road, Vile Parle (West), Mumbai 400056, India. FAU - Belemkar, Sateesh AU - Belemkar S AD - Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM'S NMIMS, V.L. Mehta Road, Vile Parle (West), Mumbai 400056, India. LA - eng PT - Comparative Study PT - Journal Article PL - United Arab Emirates TA - Curr Protein Pept Sci JT - Current protein & peptide science JID - 100960529 RN - 9002-62-4 (Prolactin) RN - 0 (Receptors, Prolactin) RN - 5587267Z69 (Domperidone) RN - 0 (Galactogogues) RN - L4YEB44I46 (Metoclopramide) SB - IM MH - Animals MH - Rabbits MH - Female MH - *Lactation/drug effects MH - *Milk/metabolism/chemistry/drug effects MH - *Prolactin/metabolism/genetics/chemistry MH - Humans MH - Receptors, Prolactin/genetics/chemistry/metabolism MH - Domperidone/pharmacology/administration & dosage MH - *Galactogogues/pharmacology/administration & dosage MH - Metoclopramide/pharmacology/administration & dosage MH - Rats MH - Mammary Glands, Animal/drug effects/metabolism OTO - NOTNLM OT - Galactagogue OT - domperidone OT - metoclopramide OT - milk nutrition OT - prolactin OT - rabbit. OT - shatavari EDAT- 2024/09/04 12:42 MHDA- 2025/02/19 06:21 CRDT- 2024/09/04 07:43 PHST- 2024/02/29 00:00 [received] PHST- 2024/06/12 00:00 [revised] PHST- 2024/07/15 00:00 [accepted] PHST- 2025/02/19 06:21 [medline] PHST- 2024/09/04 12:42 [pubmed] PHST- 2024/09/04 07:43 [entrez] AID - CPPS-EPUB-142749 [pii] AID - 10.2174/0113892037300581240830052536 [doi] PST - ppublish SO - Curr Protein Pept Sci. 2025;26(2):125-138. doi: 10.2174/0113892037300581240830052536. PMID- 39228846 OWN - NLM STAT- MEDLINE DCOM- 20240904 LR - 20240906 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 12 DP - 2024 TI - "Track style" children's fundamental movement skills test: construction and verification of an efficient evaluation system. PG - 1437473 LID - 10.3389/fpubh.2024.1437473 [doi] LID - 1437473 AB - OBJECTIVES: This study aimed to develop an efficient tool for assessing children's fundamental motor skills, the "Track style" Children's Fundamental Movement Skills Test (TCFMST), based on theories of motor development integrated with Chinese cultural context and physical education teaching situations. METHODS: Starting from a literature analysis, the study selected items from existing fundamental movement skill (FMS) assessments, textbooks, physical education and health standards, and children's movement guidelines to construct a pool of test items. Subsequently, the items were screened and optimized using the Delphi method. Finally, the feasibility, discrimination, difficulty, reliability, and validity of the constructed test were examined using testing methods. RESULTS: The TCFMST includes three dimensions: locomotive skills, body control skills, and manipulative skills, with a total of 10 items. The difficulty and discrimination of each item are appropriate; the correlation coefficients for retest reliability range from 0.789 to 0.943 (p < 0.01). The results of exploratory factor analysis indicate that the common factors align with the hypothesized three dimensions, indicating good structural validity of the test. The concurrent validity results show a correlation coefficient of -0.510 (p < 0.01) between the TCFMST and the total score of TGMD-3, indicating a moderate correlation between the two tests. CONCLUSION: The TCFMST developed in this study has good difficulty, discrimination, reliability, and validity. It also features strong operability, a short duration, and high interest. It can serve as an important tool for monitoring children's fundamental motor skill levels. CI - Copyright (c) 2024 Wang, Liang, Zhang, Meng and Xiong. FAU - Wang, Yubo AU - Wang Y AD - Physical Education and Sports School, Soochow University, Suzhou, Jiangsu, China. FAU - Liang, Shuang AU - Liang S AD - High School to Nanjing Normal University, Nanjing, Jiangsu, China. FAU - Zhang, Baofeng AU - Zhang B AD - Physical Education and Sports School, Soochow University, Suzhou, Jiangsu, China. FAU - Meng, Lingyue AU - Meng L AD - Physical Education and Sports School, Soochow University, Suzhou, Jiangsu, China. FAU - Xiong, Yan AU - Xiong Y AD - Physical Education and Sports School, Guangzhou University, Guangzhou, Guangdong, China. LA - eng PT - Journal Article DEP - 20240819 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Motor Skills/physiology MH - Child MH - Reproducibility of Results MH - Female MH - Male MH - Delphi Technique MH - China MH - Child Development/physiology PMC - PMC11369310 OTO - NOTNLM OT - Delphi method OT - assessment system construction OT - child OT - fundamental movement skills OT - motor development OT - physical activities COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/09/04 06:42 MHDA- 2024/09/04 06:43 PMCR- 2024/08/19 CRDT- 2024/09/04 04:29 PHST- 2024/05/23 00:00 [received] PHST- 2024/07/29 00:00 [accepted] PHST- 2024/09/04 06:43 [medline] PHST- 2024/09/04 06:42 [pubmed] PHST- 2024/09/04 04:29 [entrez] PHST- 2024/08/19 00:00 [pmc-release] AID - 10.3389/fpubh.2024.1437473 [doi] PST - epublish SO - Front Public Health. 2024 Aug 19;12:1437473. doi: 10.3389/fpubh.2024.1437473. eCollection 2024. PMID- 39228560 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240906 IS - 2249-4863 (Print) IS - 2278-7135 (Electronic) IS - 2249-4863 (Linking) VI - 13 IP - 8 DP - 2024 Aug TI - Influences of role models and other factors on physical activity amongst 6 to 16 years overweight and obese students. PG - 3238-3244 LID - 10.4103/jfmpc.jfmpc_188_24 [doi] AB - BACKGROUND: Physical activity is an essential aspect of living a healthy lifestyle, which offers a myriad of benefits for both the body and the mind. Nonetheless, a family history of obesity can pose significant challenges to achieving and maintaining a healthy weight, which is further exacerbated by the academic stress. Individuals who have a role model that prioritizes physical activity are more likely to develop positive and healthy habits in their lives. OBJECTIVES: The study aimed to examine how role models affect physical activity and its impact on addressing challenges of family obesity history and academic stress in school children. METHODS: This cross-sectional study was conducted from October 2019 to April 2020 in three schools in Amritsar district selected by lottery method of simple random sampling. Out of 4226 students, 355 overweight and obese students were interviewed regarding their physical activity. An informed written assent and consent was taken from the children and guardians respectively. Mothers of 6 to 11-year-old students and students aged 12 to 16 were interviewed using a pre-designed, validated, semi-structured questionnaire. RESULTS: 51.3% had a family history of obesity while 14.9% and 14.6% of parents of overweight students had hypertension and diabetes, respectively. Over half (52.7%) lacked interest in physical activity and almost 33.5% of males were inactive. Students who chose movie actors as role models (71.1%) and those who found their role models' information reliable (83.2%) were more likely to participate in physical activity. Of the 247 students who were knowledgeable about healthy living, a significant majority of 70.4% engaged in physical activity while 76% of overweight/obese students reported academic stress as a barrier. CONCLUSIONS: Study shows majority engage in physical activity regardless of gender. Over 70% have family history of obesity and healthy lifestyle knowledge. Stress reduces physical activity and students with movie/sports/fitness role models have better activity levels. Reasons for not engaging included dislike for sports and lack of time. CI - Copyright: (c) 2024 Journal of Family Medicine and Primary Care. FAU - Batish, Rohit AU - Batish R AD - Department of Community Medicine, GMC Patiala, Punjab, India. FAU - Oberoi, Simmi AU - Oberoi S AD - Department of Community Medicine, GMC Patiala, Punjab, India. FAU - Singh, Harmanjeet AU - Singh H AD - Department of PMR, GMC Patiala, Punjab, India. FAU - Jain, Ira AU - Jain I AD - Department of Community Medicine, GMC Patiala, Punjab, India. FAU - Singh, Amandev AU - Singh A AD - Department of Community Medicine, GMC Patiala, Punjab, India. FAU - Garg, Arsh AU - Garg A AD - Department of Community Medicine, GMC Patiala, Punjab, India. FAU - Suri, Bani AU - Suri B AD - Intern, Department of Community Medicine, GMC Patiala, Punjab, India. FAU - Kaur, Avneet AU - Kaur A AD - Intern, Department of Community Medicine, GMC Patiala, Punjab, India. LA - eng PT - Journal Article DEP - 20240726 PL - India TA - J Family Med Prim Care JT - Journal of family medicine and primary care JID - 101610082 PMC - PMC11368328 OTO - NOTNLM OT - Pediatric obesity OT - family health history OT - mentorship OT - physical inactivity COIS- There are no conflicts of interest. EDAT- 2024/09/04 06:42 MHDA- 2024/09/04 06:43 PMCR- 2024/08/01 CRDT- 2024/09/04 04:26 PHST- 2024/02/04 00:00 [received] PHST- 2024/03/18 00:00 [revised] PHST- 2024/04/01 00:00 [accepted] PHST- 2024/09/04 06:43 [medline] PHST- 2024/09/04 06:42 [pubmed] PHST- 2024/09/04 04:26 [entrez] PHST- 2024/08/01 00:00 [pmc-release] AID - JFMPC-13-3238 [pii] AID - 10.4103/jfmpc.jfmpc_188_24 [doi] PST - ppublish SO - J Family Med Prim Care. 2024 Aug;13(8):3238-3244. doi: 10.4103/jfmpc.jfmpc_188_24. Epub 2024 Jul 26. PMID- 39226911 OWN - NLM STAT- MEDLINE DCOM- 20241008 LR - 20260621 IS - 2379-3708 (Electronic) IS - 2379-3708 (Linking) VI - 9 IP - 19 DP - 2024 Sep 3 TI - Lipidomics of infant mesenchymal stem cells associate with the maternal milieu and child adiposity. LID - 10.1172/jci.insight.180016 [doi] LID - e180016 AB - Our objective was to interrogate mesenchymal stem cell (MSC) lipid metabolism and gestational exposures beyond maternal body mass that may contribute to child obesity risk. MSCs were cultured from term infants of mothers with obesity (n = 16) or normal weight (n = 15). In MSCs undergoing myogenesis in vitro, we used lipidomics to distinguish phenotypes by unbiased cluster analysis and lipid challenge (24-hour excess fatty acid [24hFA]). We measured MSC AMP-activated protein kinase (AMPK) activity and fatty acid oxidation (FAO), and a composite index of maternal glucose, insulin, triglycerides, free fatty acids, TNF-alpha, and high-density lipoprotein and total cholesterol in fasting blood from mid and late gestation (~17 and ~27 weeks, respectively). We measured child adiposity at birth (n = 29), 4-6 months (n = 29), and 4-6 years (n = 13). Three MSC clusters were distinguished by triacylglycerol (TAG) stores, with greatest TAGs in Cluster 2. All clusters increased acylcarnitines and TAGs with 24hFA, although Cluster 2 was more pronounced and corresponded to AMPK activation and FAO. Maternal metabolic markers predicted MSC clusters and child adiposity at 4-6 years (both highest in Cluster 3). Our data support the notion that MSC phenotypes are predicted by comprehensive maternal metabolic milieu exposures, independent of maternal BMI, and suggest utility as an at-birth predictor for child adiposity, although validation with larger longitudinal samples is warranted. FAU - Gyllenhammer, Lauren E AU - Gyllenhammer LE AD - Department of Pediatrics, University of California, Irvine, School of Medicine, Irvine, California, USA. FAU - Zaegel, Vincent AU - Zaegel V AD - Department of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FAU - Duensing, Allison M AU - Duensing AM AD - Department of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FAU - Lixandrao, Manoel E AU - Lixandrao ME AD - Department of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FAU - Dabelea, Dana AU - Dabelea D AD - The Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, Aurora, Colorado, USA. AD - Department of Epidemiology, Colorado School of Public Health. AD - Department of Pediatrics, and. FAU - Bergman, Bryan C AU - Bergman BC AD - Department of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FAU - Boyle, Kristen E AU - Boyle KE AD - Department of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. AD - The Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, Aurora, Colorado, USA. LA - eng GR - P30 DK048520/DK/NIDDK NIH HHS/United States GR - R01 DK076648/DK/NIDDK NIH HHS/United States GR - UG3 OD023248/OD/NIH HHS/United States GR - R00 HD097302/HD/NICHD NIH HHS/United States GR - R01 DK117168/DK/NIDDK NIH HHS/United States GR - K99 HD097302/HD/NICHD NIH HHS/United States GR - UL1 TR001082/TR/NCATS NIH HHS/United States GR - F31 DK137390/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20240903 PL - United States TA - JCI Insight JT - JCI insight JID - 101676073 RN - 0 (Triglycerides) RN - 0 (Fatty Acids) RN - EC 2.7.11.31 (AMP-Activated Protein Kinases) SB - IM MH - Humans MH - Female MH - *Lipidomics/methods MH - *Mesenchymal Stem Cells/metabolism MH - *Adiposity MH - Child MH - Child, Preschool MH - Infant MH - *Pediatric Obesity/metabolism MH - Pregnancy MH - Male MH - Infant, Newborn MH - Lipid Metabolism MH - Triglycerides/metabolism MH - Adult MH - Fatty Acids/metabolism MH - Obesity/metabolism MH - AMP-Activated Protein Kinases/metabolism PMC - PMC11466181 OTO - NOTNLM OT - Development OT - Fatty acid oxidation OT - Human stem cells OT - Metabolism OT - Obesity COIS- Conflict of interest: The authors have declared that no conflict of interest exists. EDAT- 2024/09/04 01:02 MHDA- 2024/10/08 12:24 PMCR- 2024/09/03 CRDT- 2024/09/03 18:52 PHST- 2024/02/05 00:00 [received] PHST- 2024/08/21 00:00 [accepted] PHST- 2024/10/08 12:24 [medline] PHST- 2024/09/04 01:02 [pubmed] PHST- 2024/09/03 18:52 [entrez] PHST- 2024/09/03 00:00 [pmc-release] AID - 180016 [pii] AID - 10.1172/jci.insight.180016 [doi] PST - epublish SO - JCI Insight. 2024 Sep 3;9(19):e180016. doi: 10.1172/jci.insight.180016. PMID- 39226630 OWN - NLM STAT- MEDLINE DCOM- 20241130 LR - 20241130 IS - 1873-7358 (Electronic) IS - 1471-0153 (Linking) VI - 55 DP - 2024 Dec TI - Further validation of the visceral sensitivity index: Psychometric properties and utility for predicting disordered eating in a diverse university sample. PG - 101920 LID - S1471-0153(24)00079-5 [pii] LID - 10.1016/j.eatbeh.2024.101920 [doi] AB - Gastrointestinal (GI) visceral sensitivity (i.e., anxiety/worry over GI sensations) may be a key maintaining factor for disordered eating; however, it is unknown whether GI visceral sensitivity predicts the range of disordered eating behaviors in nonclinical samples. The current preregistered study aimed to replicate previous construct validity findings of the Visceral Sensitivity Index (VSI; i.e., factor structure, convergent and discriminant validity) and examine its criterion-related validity for predicting a range of disordered eating attitudes and behaviors in a diverse undergraduate sample. A total of 591 university students were retained in the final analytic sample (53 % women; 23 % Hispanic [Any Race], 10 % Asian, 9 % Black) and completed the VSI, disordered eating, and additional validity measures. A confirmatory factor analysis tested the factor structure of the VSI, and correlations were used to examine convergent and discriminant validity. Hierarchical regressions and t-tests were used to examine criterion-related validity. Results replicated previous construct validity findings in a diverse undergraduate sample. Exploratory analyses supported invariance of the VSI across gender and the VSI discriminated between individuals at high- versus low-risk for an eating disorder and predicted a range of disordered eating attitudes (e.g., body dissatisfaction) and behaviors (e.g., restricting, binge eating, purging, compulsive exercise). GI-specific anxiety appears to be transdiagnostic across disordered eating behaviors and relevant across the spectrum of disordered eating severity. Future work may include developing transdiagnostic models of GI visceral sensitivity in disordered eating and investigating inclusion of the VSI in university screening efforts. CI - Copyright (c) 2024 Elsevier Ltd. All rights reserved. FAU - Poovey, Kendall AU - Poovey K AD - Department of Psychology, University of South Florida, 4204 E Fowler Ave, Tampa, FL 33620, USA. Electronic address: knpoovey@usf.edu. FAU - Brown, Tiffany A AU - Brown TA AD - Department of Psychological Sciences, Auburn University, Auburn, AL, USA. FAU - Rancourt, Diana AU - Rancourt D AD - Department of Psychology, University of South Florida, 4204 E Fowler Ave, Tampa, FL 33620, USA. LA - eng PT - Journal Article PT - Validation Study DEP - 20240827 PL - United States TA - Eat Behav JT - Eating behaviors JID - 101090048 SB - IM MH - Humans MH - Female MH - Male MH - *Feeding and Eating Disorders/diagnosis/psychology MH - *Psychometrics/instrumentation MH - Universities MH - *Students/psychology MH - Young Adult MH - Reproducibility of Results MH - Adult MH - Adolescent MH - Surveys and Questionnaires/standards MH - Anxiety/psychology/diagnosis MH - Factor Analysis, Statistical MH - Feeding Behavior/psychology OTO - NOTNLM OT - Disordered eating OT - Gastrointestinal anxiety OT - Validity OT - Visceral sensitivity COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. All authors declare they have no declarations of interest. EDAT- 2024/09/03 18:43 MHDA- 2024/12/01 15:22 CRDT- 2024/09/03 18:00 PHST- 2024/03/21 00:00 [received] PHST- 2024/08/21 00:00 [revised] PHST- 2024/08/26 00:00 [accepted] PHST- 2024/12/01 15:22 [medline] PHST- 2024/09/03 18:43 [pubmed] PHST- 2024/09/03 18:00 [entrez] AID - S1471-0153(24)00079-5 [pii] AID - 10.1016/j.eatbeh.2024.101920 [doi] PST - ppublish SO - Eat Behav. 2024 Dec;55:101920. doi: 10.1016/j.eatbeh.2024.101920. Epub 2024 Aug 27. PMID- 39223953 OWN - NLM STAT- MEDLINE DCOM- 20241217 LR - 20260602 IS - 1538-6724 (Electronic) IS - 0031-9023 (Linking) VI - 104 IP - 12 DP - 2024 Dec 6 TI - Type and Distribution of Gross Motor Activity During Physical Therapy in Young Children With Cerebral Palsy. LID - pzae125 [pii] LID - 10.1093/ptj/pzae125 [doi] AB - OBJECTIVE: Physical therapists routinely deliver and prescribe motor practice to improve function. The ability to select optimal practice regimens is limited by a current lack of detail in the measurement of motor practice. The objective of this study was to quantify the type, amount, and timing of gross motor practice during physical therapist sessions. METHODS: A secondary video coding analysis of physical therapist sessions from the iMOVE clinical trial (NCT02340026) in young children with cerebral palsy (CP) was conducted. The 37 children who completed the treatment phase were included (mean age = 22.1 months). Children could initiate pulling to stand but were unable to walk. Videos of randomly selected therapy sessions were coded for gross motor activity (422 videos total). The 10 gross motor activity codes included lying, sitting, four point, crawling, kneeling, knee walking, standing, walking, transitions between floor postures, and transitions to/from an upright posture. Twenty percent of each video was double coded for reliability. Time per session, number of bouts, and median time per bout were calculated for each gross motor activity and for 2 aggregate measures: movement time and upright time. RESULTS: Participants spent more than half of therapy time in sitting and standing combined (60.3%). Transitions occurred more frequently than any other motor activity (49.3 total transitions per session). Movement time accounted for 16.3% of therapy time. Upright time accounted for 53.3% of therapy time. CONCLUSIONS: Critical practice time to gain motor skill is not equivalent to chronological time or time spent in therapy. Toddlers with CP spent a small amount of therapy time moving. Future work should explore the relations between motor practice and rehabilitation outcomes. IMPACT: Physical therapists are ideally suited to detail the content of motor practice and ultimately to prescribe optimal patterns of motor practice. We report the characteristics of gross motor practice during therapy in children with CP. CI - (c) The Author(s) 2024. Published by Oxford University Press on behalf of the American Physical Therapy Association. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. FAU - Prosser, Laura A AU - Prosser LA AD - Division of Rehabilitation Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. AD - Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. FAU - Paremski, Athylia C AU - Paremski AC AD - Division of Rehabilitation Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FAU - Skorup, Julie AU - Skorup J AD - Department of Physical Therapy, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FAU - Alcott, Morgan AU - Alcott M AD - Department of Physical Therapy, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FAU - Pierce, Samuel R AU - Pierce SR AD - Department of Physical Therapy, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. LA - eng SI - ClinicalTrials.gov/NCT02340026 SI - ClinicalTrials.gov/NCT02340026 GR - National Institute of Disability/ GR - Independent Living and Rehabilitation Research/ PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Phys Ther JT - Physical therapy JID - 0022623 SB - IM MH - Humans MH - *Cerebral Palsy/rehabilitation/physiopathology MH - Male MH - Female MH - *Physical Therapy Modalities MH - Infant MH - Video Recording MH - Motor Skills/physiology MH - Motor Activity/physiology MH - Child, Preschool OTO - NOTNLM OT - Crawl OT - Disability OT - Infant OT - Motor Practice OT - Sit OT - Stand OT - Walk EDAT- 2024/09/03 06:43 MHDA- 2024/12/17 12:30 CRDT- 2024/09/03 02:53 PHST- 2023/08/07 00:00 [received] PHST- 2024/02/19 00:00 [revised] PHST- 2024/04/18 00:00 [accepted] PHST- 2024/12/17 12:30 [medline] PHST- 2024/09/03 06:43 [pubmed] PHST- 2024/09/03 02:53 [entrez] AID - 7748060 [pii] AID - 10.1093/ptj/pzae125 [doi] PST - ppublish SO - Phys Ther. 2024 Dec 6;104(12):pzae125. doi: 10.1093/ptj/pzae125. PMID- 39223182 OWN - NLM STAT- MEDLINE DCOM- 20240902 LR - 20250131 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Sep 2 TI - Evaluating a novel method for vitamin A analysis in an observational study of the UAE's obese population. PG - 20373 LID - 10.1038/s41598-024-71145-4 [doi] LID - 20373 AB - Vitamin A plays a critical role in various biological functions, including vision, cellular differentiation, and immune regulation. However, accurately assessing its status, particularly in obese individuals, presents challenges due to potential alterations in metabolism and distribution. This study utilized Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) methodology to precisely measure serum vitamin A concentrations in population of UAE. The methodology's reliability and precision, as demonstrated through validation procedures, underscore its potential utility in clinical settings. Employing the Multiple Reaction Monitoring mode of positive ion electrospray ionization, the LC-MS/MS system achieves a limit of detection (LOD) of 0.48 ng/mL in serum, while adhering to FDA-US regulations for accuracy and compliance. A key aspect of this study was the application of LC-MS/MS to assess vitamin A status in an obese population within UAE. By employing a diverse cohort of 452 Emirati participants, including 277 individuals from a randomized controlled trial who were assessed at baseline and at 6th month, and 175 healthy individuals aged 18-82 assessed at baseline, this study explores the relationship between obesity and vitamin A levels, shedding light on potential implications for health and well-being. It was an observational study based on a new vitamin A method and participants were asked to eat vitamin A rich foods. The robust performance of the LC-MS/MS methodology positions it as a valuable tool for clinical research. By accurately quantifying vitamin A levels in human serum, this methodology opens avenues for advancing our understanding of vitamin A physiology and its implications for health, particularly in obese populations. In summary, this LC-MS/MS methodology presents a potent tool for clinical studies, providing reliable, specific, and robust detection of vitamin A in human serum, thus, opening a new frontier for advancing our understanding of vitamin A related physiology and health in the obese population. CI - (c) 2024. The Author(s). FAU - Hakeem, Muhammad Kamran AU - Hakeem MK AD - Department of Chemistry, College of Science, United Arab Emirates University (UAEU), P.O. Box 15551, Al Ain, United Arab Emirates. FAU - El-Konaissi, Israa AU - El-Konaissi I AD - Department of Chemistry, College of Science, United Arab Emirates University (UAEU), P.O. Box 15551, Al Ain, United Arab Emirates. FAU - Alzohily, Bashar AU - Alzohily B AD - Department of Chemistry, College of Science, United Arab Emirates University (UAEU), P.O. Box 15551, Al Ain, United Arab Emirates. FAU - Gariballa, Salah AU - Gariballa S AD - Internal Medicine, Faculty of Medicine and Health Sciences, United Arab Emirates University (UAEU), P.O. Box 15551, Al Ain, United Arab Emirates. FAU - Yasin, Javed AU - Yasin J AD - Internal Medicine, Faculty of Medicine and Health Sciences, United Arab Emirates University (UAEU), P.O. Box 15551, Al Ain, United Arab Emirates. FAU - Shah, Iltaf AU - Shah I AD - Department of Chemistry, College of Science, United Arab Emirates University (UAEU), P.O. Box 15551, Al Ain, United Arab Emirates. altafshah@uaeu.ac.ae. LA - eng GR - 12S091/United Arab Emirates University/ PT - Journal Article PT - Observational Study DEP - 20240902 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 11103-57-4 (Vitamin A) SB - IM MH - Humans MH - *Vitamin A/blood MH - *Obesity/blood MH - Adult MH - United Arab Emirates/epidemiology MH - Male MH - Middle Aged MH - *Tandem Mass Spectrometry/methods MH - Female MH - Chromatography, Liquid/methods MH - Aged MH - Adolescent MH - Young Adult MH - Aged, 80 and over MH - Reproducibility of Results PMC - PMC11369191 COIS- The authors declare no competing interests. EDAT- 2024/09/03 01:42 MHDA- 2024/09/03 01:43 PMCR- 2024/09/02 CRDT- 2024/09/02 23:19 PHST- 2023/10/05 00:00 [received] PHST- 2024/08/26 00:00 [accepted] PHST- 2024/09/03 01:43 [medline] PHST- 2024/09/03 01:42 [pubmed] PHST- 2024/09/02 23:19 [entrez] PHST- 2024/09/02 00:00 [pmc-release] AID - 10.1038/s41598-024-71145-4 [pii] AID - 71145 [pii] AID - 10.1038/s41598-024-71145-4 [doi] PST - epublish SO - Sci Rep. 2024 Sep 2;14(1):20373. doi: 10.1038/s41598-024-71145-4. PMID- 39218948 OWN - NLM STAT- MEDLINE DCOM- 20240902 LR - 20240920 IS - 1477-7525 (Electronic) IS - 1477-7525 (Linking) VI - 22 IP - 1 DP - 2024 Sep 2 TI - Psychometrics of the modified family-centered care assessment short version for childhood obesity. PG - 71 LID - 10.1186/s12955-024-02284-5 [doi] LID - 71 AB - BACKGROUND: Incorporating principles of family-centered care into pediatric weight management interventions can improve the effectiveness and quality of treatment and reduce attrition rates. To assess the family-centeredness of interventions, reliable, valid, and easy-to-administer scales are needed. The purpose of the study was to develop a shortened version of the modified Family Centered Care Assessment (mFCCA) and assess its psychometric properties. METHODS: The mFCCA, a scale to assess the family-centeredness of interventions for childhood obesity, was administered to families following the Connect for Health randomized control trial evaluating the effectiveness of a primary care-based pediatric weight management intervention. We iteratively removed items from the mFCCA and used Rasch modeling to examine the reliability and validity of the shortened scale. RESULTS: We included data from 318 parents and the exploratory factor analysis showed the presence of a single factor. The results of the Rasch modeling demonstrated acceptable internal consistency of the scale (0.7) and strong validity as evidenced by the overall model fit and range of item difficulty. Following the psychometric analyses, we reduced the number of items from 24 to 8 items. CONCLUSION: The mFCCA short version demonstrates good psychometrics and can be used to evaluate the family-centeredness of childhood obesity interventions with reduced participant burden, thereby improving outcomes for children with obesity. TRIAL REGISTRATION: Clinicaltrials.gov NCT02124460 registered on April 24, 2014. CI - (c) 2024. The Author(s). FAU - Simione, Meg AU - Simione M AD - Division of General Academic Pediatrics, Department of Pediatrics, Mass General for Children, 125 Nashua Street, Suite 860, Boston, MA, 02114, USA. msimione@mgh.harvard.edu. AD - Department of Pediatrics, Harvard Medical School, Boston, MA, USA. msimione@mgh.harvard.edu. FAU - Ferreira, Paola AU - Ferreira P AD - Division of General Academic Pediatrics, Department of Pediatrics, Mass General for Children, 125 Nashua Street, Suite 860, Boston, MA, 02114, USA. FAU - Luo, Man AU - Luo M AD - Division of General Academic Pediatrics, Department of Pediatrics, Mass General for Children, 125 Nashua Street, Suite 860, Boston, MA, 02114, USA. FAU - Hoover, Clarissa AU - Hoover C AD - Family Voices, Concord, MA, USA. FAU - Perkins, Meghan AU - Perkins M AD - Division of General Academic Pediatrics, Department of Pediatrics, Mass General for Children, 125 Nashua Street, Suite 860, Boston, MA, 02114, USA. FAU - Fiechtner, Lauren AU - Fiechtner L AD - Division of General Academic Pediatrics, Department of Pediatrics, Mass General for Children, 125 Nashua Street, Suite 860, Boston, MA, 02114, USA. AD - Department of Pediatrics, Harvard Medical School, Boston, MA, USA. AD - Division of Gastroenterology and Nutrition, Department of Pediatrics, Mass General for Children, Boston, MA, USA. FAU - Taveras, Elsie M AU - Taveras EM AD - Division of General Academic Pediatrics, Department of Pediatrics, Mass General for Children, 125 Nashua Street, Suite 860, Boston, MA, 02114, USA. AD - Department of Pediatrics, Harvard Medical School, Boston, MA, USA. LA - eng SI - ClinicalTrials.gov/NCT02124460 GR - K24 HL159680/HL/NHLBI NIH HHS/United States GR - IH-1304-6739/Patient Centered Outcomes Research Institute/ GR - 9K24HL159680/HL/NHLBI NIH HHS/United States GR - K23HL161447/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Randomized Controlled Trial DEP - 20240902 PL - England TA - Health Qual Life Outcomes JT - Health and quality of life outcomes JID - 101153626 SB - IM UOF - Res Sq. 2024 May 15:rs.3.rs-4365570. doi: 10.21203/rs.3.rs-4365570/v1. PMID: 38798356 MH - Humans MH - *Psychometrics MH - *Pediatric Obesity/therapy/psychology MH - Male MH - Female MH - Child MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - Parents/psychology MH - Adolescent MH - Adult MH - Patient-Centered Care MH - Factor Analysis, Statistical PMC - PMC11367898 OTO - NOTNLM OT - Family-centered outcomes OT - Patient experience OT - Pediatrics COIS- The authors declare no competing interests. EDAT- 2024/09/02 08:46 MHDA- 2024/09/02 12:42 PMCR- 2024/09/02 CRDT- 2024/09/01 23:19 PHST- 2024/05/03 00:00 [received] PHST- 2024/08/15 00:00 [accepted] PHST- 2024/09/02 12:42 [medline] PHST- 2024/09/02 08:46 [pubmed] PHST- 2024/09/01 23:19 [entrez] PHST- 2024/09/02 00:00 [pmc-release] AID - 10.1186/s12955-024-02284-5 [pii] AID - 2284 [pii] AID - 10.1186/s12955-024-02284-5 [doi] PST - epublish SO - Health Qual Life Outcomes. 2024 Sep 2;22(1):71. doi: 10.1186/s12955-024-02284-5. PMID- 39211993 OWN - NLM STAT- MEDLINE DCOM- 20240830 LR - 20260620 IS - 2398-9238 (Electronic) IS - 2398-9238 (Linking) VI - 7 IP - 5 DP - 2024 Sep TI - L-DOPA Test in the Diagnosis of Childhood Short Stature: Evaluation of Growth Hormone Peaks Over Time. PG - e70000 LID - 10.1002/edm2.70000 [doi] LID - e70000 AB - INTRODUCTION: In childhood, growth hormone (GH) deficiency (GHD) diagnosis is based on auxological assessment and biochemical provocative tests, whose reliability remains disputed. Recently, several papers have been published on standardising the duration of some tests. The aim of our study was to analyse the possible length reduction of the L-DOPA provocative test. METHODS: We retrospectively investigated the response of GH to L-DOPA in 256 children, analysing 267 tests (some patients were retested over time for the persistence of severe auxopathy). We studied the same data considering GH peak threshold both at 8 ng/mL (Italian GHD cut-off) and at 10 ng/mL (international cut-off). Based on stimulation tests, patients were divided into two groups: GHD and no-GHD short children. We described the results in the whole population and then clustering for gender and pubertal stage. We termed as index the test stopped at 90 min. RESULTS: The GH peak after L-DOPA mostly occurred at 60 min. The sensitivity of the index test was the highest, while the specificity was slightly higher using the 8 ng/mL threshold (specificity = 0.68; 95% CI 0.60-0.76) then using the 10 ng/mL threshold (specificity = 0.56; 95% CI 0.47-0.65) at 90 min. The two ROC curves showed moderate performance of the test at 90 min. While the negative predictive value was 100% in both tests, the positive predictive value was slightly better with 10 ng/mL cut-off. Considering the two groups established by GHD definition and placing a GH threshold at 10 ng/mL, stopping L-DOPA test time at 90 min would have changed the test result and subsequentially patient's classification in 3/267 of the analysed tests (1.1%), while with the Italian GH threshold value at 8 ng/mL in 7/267 of the tests (2.6%). CONCLUSIONS: Our research shows that omitting 120-min time reduces L-DOPA test specificity, especially with GHD cut-off at 10 ng/mL. CI - (c) 2024 The Author(s). Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd. FAU - Castelli, Barbara AU - Castelli B AUID- ORCID: 0000-0003-0311-8824 AD - Health Sciences Department, University of Florence, Florence, Italy. AD - Meyer Children's Hospital IRCCS, Florence, Italy. FAU - De Santis, Rita AU - De Santis R AD - Meyer Children's Hospital IRCCS, Florence, Italy. FAU - Carrera, Simona AU - Carrera S AD - Health Sciences Department, University of Florence, Florence, Italy. AD - Meyer Children's Hospital IRCCS, Florence, Italy. FAU - Malanima, Marco Andrea AU - Malanima MA AD - Clinical Trial Center, Careggi University Hospital, Florence, Italy. FAU - De Masi, Salvatore AU - De Masi S AD - Clinical Trial Center, Careggi University Hospital, Florence, Italy. FAU - Stagi, Stefano AU - Stagi S AD - Health Sciences Department, University of Florence, Florence, Italy. AD - Meyer Children's Hospital IRCCS, Florence, Italy. LA - eng PT - Journal Article PL - England TA - Endocrinol Diabetes Metab JT - Endocrinology, diabetes & metabolism JID - 101732442 RN - 46627O600J (Levodopa) RN - 12629-01-5 (Human Growth Hormone) SB - IM MH - Humans MH - *Levodopa/administration & dosage MH - Child MH - Male MH - Female MH - Retrospective Studies MH - *Human Growth Hormone/deficiency/blood/administration & dosage MH - Adolescent MH - *Body Height MH - Growth Disorders/diagnosis/etiology MH - Child, Preschool MH - Time Factors MH - Sensitivity and Specificity PMC - PMC11362654 OTO - NOTNLM OT - L-DOPA OT - children OT - growth hormone COIS- The authors declare no conflicts of interest. EDAT- 2024/08/31 09:48 MHDA- 2024/08/31 09:49 PMCR- 2024/08/30 CRDT- 2024/08/30 04:43 PHST- 2024/08/04 00:00 [revised] PHST- 2024/01/02 00:00 [received] PHST- 2024/08/11 00:00 [accepted] PHST- 2024/08/31 09:49 [medline] PHST- 2024/08/31 09:48 [pubmed] PHST- 2024/08/30 04:43 [entrez] PHST- 2024/08/30 00:00 [pmc-release] AID - EDM270000 [pii] AID - 10.1002/edm2.70000 [doi] PST - ppublish SO - Endocrinol Diabetes Metab. 2024 Sep;7(5):e70000. doi: 10.1002/edm2.70000. PMID- 39211458 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240901 IS - 2477-4073 (Electronic) IS - 2528-181X (Print) IS - 2477-4073 (Linking) VI - 10 IP - 4 DP - 2024 TI - Maternal knowledge on nutritional-focused nurturing care and associated factors among women with stunted children aged 6-23 months in Yogyakarta, Indonesia: A cross-sectional study. PG - 472-480 LID - 10.33546/bnj.3481 [doi] AB - BACKGROUND: Childhood stunting poses serious long-term risks to cognitive development, education, and adult productivity. While research has explored stunting's causes and effects, there is a lack of focus on maternal knowledge of nutrition-focused nurturing care for stunted children. This gap limits the ability to design effective interventions that target improved caregiving practices. OBJECTIVE: This study aimed to assess maternal knowledge of nutrition-focused nurturing care and explore associated factors, including child gender, maternal age, education, income, and prior exposure to nurturing care information, among mothers of stunted children aged 6-23 months in Indonesia. METHODS: A cross-sectional study was conducted with 73 mothers in Kulon Progo, Yogyakarta. Data were collected from February to March 2024 using a validated self-assessment questionnaire covering four domains: responsive caregiving, early learning opportunities, safety and security, and supportive caregiver well-being. Statistical analyses, including t-tests and one-way ANOVA, were performed. RESULTS: Overall maternal knowledge of nurturing care was high, with a mean score of 25.15 (SD = 4.72). Factors significantly associated with higher knowledge included having male children (p = 0.017), being aged 30-34 years (p = 0.035), possessing higher education levels (p = 0.002), and prior exposure to nurturing care information (p <0.001). Family income significantly influenced knowledge in the domain of early learning opportunities (p = 0.006), though not in other areas. CONCLUSION: Maternal knowledge of nutrition-focused nurturing care was influenced by child gender, maternal age, education, income, and prior exposure to nurturing care information. These findings emphasize the importance of focused educational interventions in nursing practice to enhance maternal knowledge. Addressing these factors can help align nursing strategies better to support the healthy growth and development of children. CI - (c) The Author(s) 2024. FAU - Haryanti, Fitri AU - Haryanti F AUID- ORCID: 0000-0003-4511-8021 AD - Department of Pediatric and Maternity Nursing, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia. FAU - Hartini, Sri AU - Hartini S AUID- ORCID: 0000-0002-5535-9665 AD - Department of Pediatric and Maternity Nursing, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia. FAU - Akhmadi AU - Akhmadi AUID- ORCID: 0000-0002-1018-6916 AD - Department of Mental and Community Health Nursing, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia. FAU - Andarwati, Fitriana AU - Andarwati F AUID- ORCID: 0009-0001-5560-5731 AD - Master of Nursing Program, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia. FAU - Risnawati, Hani AU - Risnawati H AUID- ORCID: 0009-0009-8911-0372 AD - Master of Nursing Program, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia. FAU - Pratiwi, Alissa Nur AU - Pratiwi AN AUID- ORCID: 0009-0008-1504-6382 AD - Bachelor of Nursing Program, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia. FAU - Kusumawati, Ananda Sekar AU - Kusumawati AS AUID- ORCID: 0009-0005-1762-9678 AD - Bachelor of Nursing Program, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia. FAU - Cahyani, Redyta Dwi AU - Cahyani RD AUID- ORCID: 0009-0003-1146-8864 AD - Bachelor of Nursing Program, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia. FAU - Lusmilasari, Lely AU - Lusmilasari L AUID- ORCID: 0000-0001-5137-692X AD - Department of Pediatric and Maternity Nursing, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia. LA - eng PT - Journal Article DEP - 20240828 PL - Indonesia TA - Belitung Nurs J JT - Belitung nursing journal JID - 101685037 PMC - PMC11350353 OTO - NOTNLM OT - Indonesia OT - child development OT - cross-sectional studies OT - health knowledge OT - stunting COIS- The authors affirm that there were no financial or commercial conflicts of interest throughout this study and state that they have no competing interests with the funders. EDAT- 2024/08/31 09:46 MHDA- 2024/08/31 09:47 PMCR- 2024/08/28 CRDT- 2024/08/30 04:25 PHST- 2024/06/25 00:00 [received] PHST- 2024/07/28 00:00 [revised] PHST- 2024/08/12 00:00 [accepted] PHST- 2024/08/31 09:47 [medline] PHST- 2024/08/31 09:46 [pubmed] PHST- 2024/08/30 04:25 [entrez] PHST- 2024/08/28 00:00 [pmc-release] AID - BNJ-10-4-472 [pii] AID - 10.33546/bnj.3481 [doi] PST - epublish SO - Belitung Nurs J. 2024 Aug 28;10(4):472-480. doi: 10.33546/bnj.3481. eCollection 2024. PMID- 39210756 OWN - NLM STAT- MEDLINE DCOM- 20240830 LR - 20240830 IS - 1784-3227 (Print) IS - 1784-3227 (Linking) VI - 87 IP - 2 DP - 2024 Apr-Jun TI - Exploring parental thoughts and clinical experiences on blended food in a paediatric population, a qualitative study. PG - 241-254 LID - 10.51821/87.2.12122 [doi] AB - BACKGROUND: There's a growing interest in blended food (BF) as an alternative to commercial food (CF) for tube-fed children. Thus, we investigated parental and medical experiences with BF as an option for tube feeding in children. METHODS: In this cross-sectional study, all patients were already using BF, chosen by parents. In March 2022, all patients using BF provided consent and completed a questionnaire assessing their experiences. Medical data were collected retrospectively from patient charts, including biometric changes, dietary adjustments, and nutritional status. A non-validated parent satisfaction score was computed from 17 questions, rated on a scale from one to five. A score of >/= 51 points, indicating an average score of > 3 per question, was deemed indicative of a positive parental experience with BF. RESULTS: Nine children receiving BF were identified (median age: 4.7 years; weight: 14.9 kg; 66% male). All parents were satisfied with BF, reflected in the parent satisfaction score. Parents cited reduced feeding-related discomforts as the main reason for switching to BF. Weight (+0.3 SD) and length (+0.5 SD) showed positive changes. None discontinued BF, though modifications were made for five patients by the dietician. Nutritional deficiencies, mainly iron with or without zinc deficiency, were observed in four patients, with uncertain onset due to lack of pre-BF laboratory testing. CONCLUSIONS: In this small BF cohort overseen by an experienced multidisciplinary team, BF was well tolerated, resulting in high parental satisfaction and maintaining good nutritional status. CI - (c) Acta Gastro-Enterologica Belgica. FAU - Verheije, R AU - Verheije R AD - University Hospitals Gasthuisberg Leuven and KU Leuven, Belgium. FAU - Carbone, F AU - Carbone F AD - University Hospitals Gasthuisberg Leuven, Belgium. FAU - Bosmans, T AU - Bosmans T AD - University Hospitals Gasthuisberg Leuven and KU Leuven, Belgium. FAU - Van Scheppingen, L AU - Van Scheppingen L AD - Maastricht University Hospital, The Netherlands. FAU - van Hoeve, K AU - van Hoeve K AD - University Hospitals Gasthuisberg Leuven and KU Leuven, Belgium. FAU - Hoffman, I AU - Hoffman I AD - University Hospitals Gasthuisberg Leuven and KU Leuven, Belgium. LA - eng PT - Journal Article PL - Belgium TA - Acta Gastroenterol Belg JT - Acta gastro-enterologica Belgica JID - 0414075 SB - IM MH - Humans MH - Male MH - Female MH - Cross-Sectional Studies MH - *Parents/psychology MH - Child, Preschool MH - *Enteral Nutrition/psychology MH - Child MH - Retrospective Studies MH - Qualitative Research MH - Infant MH - Surveys and Questionnaires MH - Nutritional Status OTO - NOTNLM OT - blended diets OT - blended food OT - tube feeding COIS- The authors declare that they have no conflict of interest EDAT- 2024/08/31 09:46 MHDA- 2024/08/31 09:47 CRDT- 2024/08/30 03:51 PHST- 2024/08/31 09:47 [medline] PHST- 2024/08/31 09:46 [pubmed] PHST- 2024/08/30 03:51 [entrez] AID - 10.51821/87.2.12122 [doi] PST - ppublish SO - Acta Gastroenterol Belg. 2024 Apr-Jun;87(2):241-254. doi: 10.51821/87.2.12122. PMID- 39206637 OWN - NLM STAT- MEDLINE DCOM- 20240829 LR - 20250520 IS - 1745-5065 (Electronic) IS - 1745-5057 (Print) IS - 1745-5057 (Linking) VI - 20 DP - 2024 Jan-Dec TI - Nutrition knowledge among pregnant women in Lebanon: A cross-sectional study. PG - 17455057241272216 LID - 10.1177/17455057241272216 [doi] LID - 17455057241272216 AB - BACKGROUND: Women's knowledge of the nutritional guidelines during pregnancy can affect the health and nutritional status of both mother and child. Having good nutritional information related to maternal dietary intake and healthy lifestyles is therefore of great importance. However, there is limited published research that demonstrates pregnant women's knowledge of the nutritional guidelines during pregnancy in Lebanon. OBJECTIVE: To assess the knowledge on food sources and energy recommendations as well as food safety practices and diet-health relationship among women during pregnancy in Lebanon. DESIGN: A cross-sectional study. METHODS: The study was conducted at prenatal care clinics in Lebanon, and all pregnant women present, regardless of nationality, were invited to complete the self-administered nutrition knowledge questionnaire. The study assessed five different nutrition knowledge domains (food sources of nutrients, dietary behaviors, food safety knowledge, micronutrients for fetal development, and energy requirements and weight gain) and the demographic characteristics of pregnant women who completed a multidimensional online survey based on validated and existing measures. RESULTS: Four-hundred and ten responses were obtained. Approximately half of respondents (47%) held a university degree, for 42% of women this was their first pregnancy, and 71% had a planned pregnancy. Among the different nutrition knowledge domains, the highest levels of knowledge were for the behaviors that can minimize the effect of nausea/vomiting, heartburn, and constipation during pregnancy (63.9%) and the lowest levels of knowledge was for the importance of iodine and omega-3 fatty acids in pregnancy (28.4%). Most of females knew about food safety practices during pregnancy (72.9%) but less than half were knowledgeable about listeriosis contamination (45.9%), and the types of fish that are the safest to select during pregnancy (47.8%). CONCLUSION: Despite the fact that pregnant women had an adequate level of knowledge in different nutrition-related areas, there was inadequate level of awareness related to critical nutrients and behaviors that can have adverse effects on mother and/or baby. Therefore, there is a need to focus on specific maternal nutrition aspects such as iron-rich foods, listeriosis food contamination, and nutrients that aid in fetal brain and retina development. FAU - Rizk, Jessy AU - Rizk J AUID- ORCID: 0009-0000-4714-4544 AD - Department of Life Sciences, University of Nicosia, Nicosia, Cyprus. FAU - Andreou, Eleni AU - Andreou E AD - Department of Life Sciences, University of Nicosia, Nicosia, Cyprus. FAU - Hileti, Dona AU - Hileti D AD - Department of Life Sciences, University of Nicosia, Nicosia, Cyprus. FAU - Ghaddar, Ali AU - Ghaddar A AD - Department of Biomedical Science, Lebanese International University, Beirut, Lebanon. AD - Public Health Research Group, University of Alicante, Alicante, Spain. FAU - Zampelas, Antonis AU - Zampelas A AD - Department of Life Sciences, University of Nicosia, Nicosia, Cyprus. AD - Laboratory of Dietetics and Quality of Life, Department of Food Science and Human Nutrition, Agricultural University of Athens, Athens, Greece. LA - eng PT - Journal Article PL - United States TA - Womens Health (Lond) JT - Women's health (London, England) JID - 101271249 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Cross-Sectional Studies MH - Lebanon MH - *Health Knowledge, Attitudes, Practice MH - Adult MH - *Pregnant People/psychology MH - Surveys and Questionnaires MH - Diet MH - Young Adult MH - Prenatal Care/methods MH - Nutritional Status PMC - PMC11363051 OAB - Nutrition knowledge among pregnant women in LebanonWomen who adopt healthy dietary patterns during pregnancy are more likely to prevent adverse birth outcomes. Pregnant women from the Middle East have limited knowledge of the dietary guidelines for healthy eating during pregnancy. Yet there are no studies on nutritional knowledge of pregnant women residing in the Middle East. This study aimed to investigate the nutrition knowledge of pregnant women in Lebanon, which includes food sources of nutrients, diet-health relationships, food safety, and energy requirements during pregnancy. The highest levels of nutrition knowledge were for the behaviors that can reduce the effect of nausea and vomiting, heartburn, and constipation during pregnancy and the lowest levels of knowledge were for the importance of iodine and omega-3 fatty acids in pregnancy. The level of awareness related to critical nutrients and behaviors that can have adverse effects on mother and/or baby is inadequate. Lebanese women need to obtain their information from reliable sources such as their healthcare providers. Collaboration between healthcare providers and dietitians is essential to ensure that pregnant women receive comprehensive and accurate nutritional advice throughout their pregnancy journey. OABL- eng OTO - NOTNLM OT - diet OT - knowledge OT - nutrition OT - pregnancy OT - women COIS- The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2024/08/31 09:50 MHDA- 2024/09/01 16:15 PMCR- 2024/08/29 CRDT- 2024/08/29 06:03 PHST- 2024/09/01 16:15 [medline] PHST- 2024/08/31 09:50 [pubmed] PHST- 2024/08/29 06:03 [entrez] PHST- 2024/08/29 00:00 [pmc-release] AID - 10.1177_17455057241272216 [pii] AID - 10.1177/17455057241272216 [doi] PST - ppublish SO - Womens Health (Lond). 2024 Jan-Dec;20:17455057241272216. doi: 10.1177/17455057241272216. PMID- 39203890 OWN - NLM STAT- MEDLINE DCOM- 20240829 LR - 20240903 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 16 DP - 2024 Aug 18 TI - Development and Validation of a Questionnaire to Measure Adherence to a Mediterranean-Type Diet in Youth. LID - 10.3390/nu16162754 [doi] LID - 2754 AB - Proper nutrition during childhood is crucial for preventing chronic diseases and ensuring optimal growth. This study aimed to develop and validate the Korean version of the KIDMED (K-KIDMED) questionnaire to accurately measure Mediterranean diet (MD) adherence among Korean children and adolescents. A total of 226 parents, representing their children and adolescents, completed the K-KIDMED, a 112-item food frequency questionnaire (FFQ), and a 24-h dietary recall method through an anonymous online survey. The K-KIDMED comprised 11 questions, with five excluded from the original scoring as they did not apply to the FFQ. Scores were categorized into three levels of adherence to the MD: low (1 or less), average (2-4), and good (5 or more). The agreement between total MD scores from the Korean version of the Mediterranean diet adherence screener and the FFQ was moderate (intraclass correlation coefficient = 0.455, 95% confidence interval: 0.346, 0.553). Among the 226 children and adolescents, 36.7% had low adherence to the KIDMED, 43.3% had intermediate adherence, and 19.9% had good adherence. Higher K-KIDMED scores were correlated with greater intakes of fiber, vitamin K, vitamin B6, and potassium (all p < 0.05). We developed the K-KIDMED as a valid tool to assess MD adherence in Korean children and adolescents. FAU - Kwon, Yu-Jin AU - Kwon YJ AUID- ORCID: 0000-0002-9021-3856 AD - Department of Family Medicine, Yongin Severance Hospital, College of Medicine, Yonsei University, Yongin 16995, Republic of Korea. FAU - Park, Young-Hwan AU - Park YH AD - Incheon Grand Internal Medicine Clinic, Incheon 22184, Republic of Korea. FAU - Lee, Yae-Ji AU - Lee YJ AUID- ORCID: 0000-0002-1411-1938 AD - Department of Biostatistics and Computing, Yonsei University, Seoul 03722, Republic of Korea. FAU - Lim, Li-Rang AU - Lim LR AD - Department of Family Medicine, Severance Hospital, College of Medicine, Yonsei University, Seoul 03722, Republic of Korea. FAU - Lee, Ji-Won AU - Lee JW AUID- ORCID: 0000-0002-2666-4249 AD - Department of Family Medicine, Severance Hospital, College of Medicine, Yonsei University, Seoul 03722, Republic of Korea. AD - Institute for Innovation in Digital Healthcare, Yonsei University, Seoul 03722, Republic of Korea. LA - eng GR - 20018384/Ministry of Trade, Industry and Energy/ PT - Journal Article PT - Validation Study DEP - 20240818 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Diet, Mediterranean/statistics & numerical data MH - Female MH - Male MH - Adolescent MH - Child MH - Republic of Korea MH - Surveys and Questionnaires MH - Reproducibility of Results MH - Patient Compliance/statistics & numerical data MH - Diet Surveys MH - Feeding Behavior PMC - PMC11356957 OTO - NOTNLM OT - Mediterranean diet OT - adherence OT - questionnaire OT - validation OT - youth COIS- The authors declare no conflicts of interest. EDAT- 2024/08/31 09:50 MHDA- 2024/09/01 16:20 PMCR- 2024/08/18 CRDT- 2024/08/29 01:26 PHST- 2024/07/18 00:00 [received] PHST- 2024/08/14 00:00 [revised] PHST- 2024/08/16 00:00 [accepted] PHST- 2024/09/01 16:20 [medline] PHST- 2024/08/31 09:50 [pubmed] PHST- 2024/08/29 01:26 [entrez] PHST- 2024/08/18 00:00 [pmc-release] AID - nu16162754 [pii] AID - nutrients-16-02754 [pii] AID - 10.3390/nu16162754 [doi] PST - epublish SO - Nutrients. 2024 Aug 18;16(16):2754. doi: 10.3390/nu16162754. PMID- 39203874 OWN - NLM STAT- MEDLINE DCOM- 20240829 LR - 20240919 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 16 DP - 2024 Aug 16 TI - Socio-Demographic Factors, Behaviors, Motivations, and Attitudes in Food Waste Management of Romanian Households. LID - 10.3390/nu16162738 [doi] LID - 2738 AB - (1) Background: Food waste (FW) in Romania is 70 Kg/capita/year, while 70% of food waste comes from public catering, retail services, and households (over 50%-47 million tons). The present study investigates the socio-demographic factors, behaviors, motivations, and attitudes related to food waste management in Romanian households. (2) Methods: A cross-sectional observational study was conducted using an online questionnaire via the Google Forms platform from 15 April 2023 to 15 May 2023. The questionnaire was designed to assess various aspects, such as some socio-demographic information (age, sex, occupation, area of residence, study level, household members number, children <18 years of age); the personal involvement and frequency of food purchases and homemade food cooking; the main sources that generate food waste; the motivation and frequency with which food waste occurs; the level of awareness regarding the impact of food waste; the respondents' intentions regarding sustainable behaviors and practices for food management; the level of information and familiarity of the respondents with the notions of validity and how these may influence their food consumption decisions. (3) Results: The results show that FW incidence is occasionally (42%), very rarely (43.33%), frequently (15%), and no food waste was reported by 2.66% of respondents. The 35-44 age category records the highest FW frequency, followed by 18-24. The most wasted are homemade food (29.67%), bread and bakery products (27.00%), and fruits and vegetables (14.33%). High involvement in purchasing and buying food following a previously established list reduces FW frequency. The same is valid for high daily involvement in food and homemade cooking. High interest in the FW problem and its perception as a waste of money leads to diminishing it, while guilty feelings increase the FW level (37.50% to 73.33%). (4) Conclusions: The present study shows that household food waste management is a multifactorial process that involves numerous socio-demographic, behavioral, and emotional aspects. Extensive data analysis supports our results, revealing deep self-reported information details and confirming its complex approach. FAU - Morosan, Elena AU - Morosan E AD - Department of Clinical Laboratory and Food Safety, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 020956 Bucharest, Romania. FAU - Daraban, Adriana AU - Daraban A AD - Faculty of Pharmacy, "Vasile Goldis" Western University of Arad, 310045 Arad, Romania. FAU - Popovici, Violeta AU - Popovici V AUID- ORCID: 0000-0001-9696-5728 AD - Center for Mountain Economics, "Costin C. Kiritescu" National Institute of Economic Research (INCE-CEMONT), Romanian Academy, 725700 Vatra-Dornei, Romania. FAU - Rusu, Andreea AU - Rusu A AD - Faculty of Pharmacy, "Vasile Goldis" Western University of Arad, 310045 Arad, Romania. FAU - Ilie, Elena Iuliana AU - Ilie EI AD - Faculty of Pharmacy, University of Medicine and Pharmacy "Carol Davila", 020956 Bucharest, Romania. FAU - Licu, Monica AU - Licu M AUID- ORCID: 0009-0004-4516-791X AD - Department of Medical Psychology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania. FAU - Karampelas, Oana AU - Karampelas O AD - Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 020956 Bucharest, Romania. FAU - Lupuliasa, Dumitru AU - Lupuliasa D AD - Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 020956 Bucharest, Romania. FAU - Ozon, Emma Adriana AU - Ozon EA AD - Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 020956 Bucharest, Romania. FAU - Maravela, Vanessa Maria AU - Maravela VM AD - Faculty of Pharmacy, University of Medicine and Pharmacy "Carol Davila", 020956 Bucharest, Romania. FAU - Popescu, Ioana Andreea AU - Popescu IA AD - Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 020956 Bucharest, Romania. LA - eng GR - The publication of this paper was supported by "Carol Davila" University of 597 Medicine and Pharmacy, through the institutional program "Publish not Perish."/ PT - Journal Article PT - Observational Study DEP - 20240816 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Romania MH - Male MH - Female MH - Cross-Sectional Studies MH - Adult MH - *Family Characteristics MH - *Motivation MH - Middle Aged MH - Surveys and Questionnaires MH - *Waste Management/methods MH - Young Adult MH - Cooking MH - Adolescent MH - Socioeconomic Factors MH - Sociodemographic Factors MH - Aged MH - Food MH - Health Knowledge, Attitudes, Practice MH - Consumer Behavior/statistics & numerical data PMC - PMC11356938 OTO - NOTNLM OT - food purchase behavior OT - food waste awareness OT - food waste frequency OT - food waste interest OT - home food cooking OT - homemade food waste OT - household food waste COIS- The authors declare no conflicts of interest. EDAT- 2024/08/31 09:53 MHDA- 2024/09/01 16:15 PMCR- 2024/08/16 CRDT- 2024/08/29 01:26 PHST- 2024/07/13 00:00 [received] PHST- 2024/08/09 00:00 [revised] PHST- 2024/08/14 00:00 [accepted] PHST- 2024/09/01 16:15 [medline] PHST- 2024/08/31 09:53 [pubmed] PHST- 2024/08/29 01:26 [entrez] PHST- 2024/08/16 00:00 [pmc-release] AID - nu16162738 [pii] AID - nutrients-16-02738 [pii] AID - 10.3390/nu16162738 [doi] PST - epublish SO - Nutrients. 2024 Aug 16;16(16):2738. doi: 10.3390/nu16162738. PMID- 39203789 OWN - NLM STAT- MEDLINE DCOM- 20240829 LR - 20240903 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 16 DP - 2024 Aug 11 TI - Genes Involved in Susceptibility to Obesity and Emotional Eating Behavior in a Romanian Population. LID - 10.3390/nu16162652 [doi] LID - 2652 AB - Obesity, a significant public health concern with high prevalence in both adults and children, is a complex disorder arising from the interaction of multiple genes and environmental factors. Advances in genome-wide association studies (GWAS) and sequencing technologies have identified numerous polygenic causes of obesity, particularly genes involved in hunger, satiety signals, adipocyte differentiation, and energy expenditure. This study investigates the relationship between six obesity-related genes (CLOCK, FTO, GHRL, LEP, LEPR, MC4R) and their impact on BMI, WC, HC, WHR, and emotional eating behavior in 220 Romanian adults. Emotional eating was assessed using the validated Emotional Eating Questionnaire (EEQ). Our analysis revealed significant variability in obesity-related phenotypes and emotional eating behaviors across different genotypes. Specifically, CLOCK/CC, FTO/AA, and LEP/AA genotypes were strongly associated with higher obesity metrics and emotional eating scores, while GHRL/TT and MC4R/CC were linked to increased BMI and WHR. The interplay between genetic predisposition and emotional eating behavior significantly influenced BMI and WHR, indicating a complex relationship between genetic and behavioral factors. This study, the first of its kind in Romania, provides a foundation for targeted interventions to prevent and reduce obesity and suggests potential strategies for gene expression modulation to mitigate the effects of emotional eating. Adopting a 'One Health' approach by creating an evidence base derived from both human and animal studies is crucial for understanding how to control obesity. FAU - Vranceanu, Maria AU - Vranceanu M AUID- ORCID: 0000-0002-2015-7684 AD - Department of Toxicology, Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, 6 Pasteur Street, 400349 Cluj-Napoca, Romania. FAU - Filip, Lorena AU - Filip L AUID- ORCID: 0000-0001-9469-3546 AD - Department of Bromatology, Hygiene, Nutrition, Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, 6 Pasteur Street, 400349 Cluj-Napoca, Romania. AD - Academy of Romanian Scientists (AOSR), 3 Ilfov St, 050044 Bucharest, Romania. FAU - Heghes, Simona-Codruta AU - Heghes SC AUID- ORCID: 0000-0001-7823-4390 AD - Department of Drug Analysis, Facullty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, 6 Pasteur Street, 400349 Cluj-Napoca, Romania. FAU - de Lorenzo, David AU - de Lorenzo D AUID- ORCID: 0000-0003-2042-0961 AD - UCL Great Ormond Street Institute of Child Health, 30 Guilford St, London WC1N 1EH, UK. FAU - Cozma-Petrut, Anamaria AU - Cozma-Petrut A AUID- ORCID: 0000-0003-4381-5544 AD - Department of Bromatology, Hygiene, Nutrition, Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, 6 Pasteur Street, 400349 Cluj-Napoca, Romania. FAU - Ghitea, Timea Claudia AU - Ghitea TC AUID- ORCID: 0000-0001-8981-1958 AD - Doctoral Scool of Biomedical Sciences, Faculty of Medicine and Pharmacy, University of Oradea, 1 Universitatii Street, 410087 Oradea, Romania. FAU - Stroia, Carmina Mariana AU - Stroia CM AD - Doctoral Scool of Biomedical Sciences, Faculty of Medicine and Pharmacy, University of Oradea, 1 Universitatii Street, 410087 Oradea, Romania. FAU - Banc, Roxana AU - Banc R AUID- ORCID: 0000-0001-6808-5723 AD - Department of Bromatology, Hygiene, Nutrition, Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, 6 Pasteur Street, 400349 Cluj-Napoca, Romania. FAU - Mirza, Oana Maria AU - Mirza OM AUID- ORCID: 0000-0003-3771-9003 AD - Department of Bromatology, Hygiene, Nutrition, Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, 6 Pasteur Street, 400349 Cluj-Napoca, Romania. FAU - Miere, Doina AU - Miere D AUID- ORCID: 0000-0001-5029-5060 AD - Department of Bromatology, Hygiene, Nutrition, Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, 6 Pasteur Street, 400349 Cluj-Napoca, Romania. FAU - Cozma, Vasile AU - Cozma V AUID- ORCID: 0000-0002-8587-3753 AD - Department of Parasitology and Parasitic Diseases, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca, 3-5, Manastur Street, 400372 Cluj-Napoca, Romania. AD - Academy of Agricultural and Forestry Sciences Gheorghe Ionescu-Sisesti (A.S.A.S.), 61, Marasti Boulevard, 011464 Bucharest, Romania. FAU - Popa, Daniela-Saveta AU - Popa DS AUID- ORCID: 0000-0001-7449-5753 AD - Department of Toxicology, Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, 6 Pasteur Street, 400349 Cluj-Napoca, Romania. LA - eng GR - N degrees 816172/University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca and by the "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca (subcontracted institution) within the project PPILOW/ PT - Journal Article DEP - 20240811 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - EC 1.14.11.33 (Alpha-Ketoglutarate-Dependent Dioxygenase FTO) RN - EC 1.14.11.33 (FTO protein, human) RN - 0 (MC4R protein, human) RN - 0 (Receptor, Melanocortin, Type 4) SB - IM MH - Humans MH - Romania/epidemiology MH - *Feeding Behavior/psychology MH - *Obesity/genetics/psychology MH - Female MH - Male MH - Adult MH - *Genetic Predisposition to Disease MH - *Emotions MH - Middle Aged MH - Body Mass Index MH - Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics MH - Genotype MH - Genome-Wide Association Study MH - Polymorphism, Single Nucleotide MH - Young Adult MH - Surveys and Questionnaires MH - Receptor, Melanocortin, Type 4/genetics PMC - PMC11357152 OTO - NOTNLM OT - CLOCK OT - FTO OT - GHRL OT - LEP OT - LEPR OT - MC4R OT - diet OT - emotional eating OT - genes OT - obesity OT - precision nutrition COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2024/08/31 09:52 MHDA- 2024/09/01 16:18 PMCR- 2024/08/11 CRDT- 2024/08/29 01:26 PHST- 2024/07/15 00:00 [received] PHST- 2024/08/06 00:00 [revised] PHST- 2024/08/08 00:00 [accepted] PHST- 2024/09/01 16:18 [medline] PHST- 2024/08/31 09:52 [pubmed] PHST- 2024/08/29 01:26 [entrez] PHST- 2024/08/11 00:00 [pmc-release] AID - nu16162652 [pii] AID - nutrients-16-02652 [pii] AID - 10.3390/nu16162652 [doi] PST - epublish SO - Nutrients. 2024 Aug 11;16(16):2652. doi: 10.3390/nu16162652. PMID- 39202478 OWN - NLM STAT- MEDLINE DCOM- 20240829 LR - 20240901 IS - 1648-9144 (Electronic) IS - 1010-660X (Print) IS - 1010-660X (Linking) VI - 60 IP - 8 DP - 2024 Jul 24 TI - A Mediation Model of Food Literacy: A Potential Relationship between Body Image Dissatisfaction and Body Mass Index. LID - 10.3390/medicina60081196 [doi] LID - 1196 AB - Background and Objectives: The global rise in obesity presents a significant public health challenge, with Turkey exhibiting one of the highest obesity rates in Europe. Body image dissatisfaction (BID) and lower food literacy (FL) have been associated with obesity, yet their interplay remains underexplored. This study aimed to investigate the relationship between body mass index (BMI), body image dissatisfaction, and FL in adults in Turkey. Materials and Methods: In total, 759 women and 419 men aged 18-64 years old were included in this study. The mean age was 31.34 +/- 11.92. A total of 1178 participants completed an online questionnaire assessing anthropometric measurements, BID, using the Stunkard Figure Rating Scale, and FL, using a validated questionnaire. The data were analyzed using descriptive statistics, correlation analysis, and mediation analysis to explore the relationships between variables in SPSS 24.0. Results: Women desired to be thinner more frequently than men, and those with negative BID were predominantly individuals with overweight or obesity. Moreover, those with higher FL scores were more likely to be satisfied with their bodies. Correlation analysis demonstrated a negative relationship between BMI and FL (r = -0.94; p = 0.001) and a positive relationship between BMI and BID (r = 0.628; p < 0.001). Mediation analysis revealed that FL mediated the relationship between BID and BMI (beta = -2.281; lower limit = -3.334, upper limit = -1.228). Conclusions: The findings highlight the importance of addressing BID and enhancing FL to mitigate obesity risk factors. This study contributes to understanding the complex interplay between BID, FL, and obesity, providing insights for public health interventions aimed at obesity prevention and management. FAU - Arslan, Neslihan AU - Arslan N AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Erzurum Technical University, 25050 Erzurum, Turkiye. FAU - Ayyildiz, Feride AU - Ayyildiz F AUID- ORCID: 0000-0003-2828-3850 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, 06490 Ankara, Turkiye. FAU - Esin, Kubra AU - Esin K AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Tokat Gaziosmanpasa University, 60250 Tokat, Turkiye. LA - eng PT - Journal Article DEP - 20240724 PL - Switzerland TA - Medicina (Kaunas) JT - Medicina (Kaunas, Lithuania) JID - 9425208 SB - IM MH - Humans MH - Female MH - Male MH - *Body Mass Index MH - Adult MH - Turkey MH - Middle Aged MH - Adolescent MH - Surveys and Questionnaires MH - Body Image/psychology MH - Obesity/psychology MH - Body Dissatisfaction/psychology MH - Young Adult MH - Mediation Analysis MH - Cross-Sectional Studies PMC - PMC11356102 OTO - NOTNLM OT - body image dissatisfaction OT - food literacy OT - obesity COIS- The authors declare that they have no competing interests. EDAT- 2024/08/31 09:43 MHDA- 2024/09/01 16:17 PMCR- 2024/07/24 CRDT- 2024/08/29 01:19 PHST- 2024/06/14 00:00 [received] PHST- 2024/07/08 00:00 [revised] PHST- 2024/07/22 00:00 [accepted] PHST- 2024/09/01 16:17 [medline] PHST- 2024/08/31 09:43 [pubmed] PHST- 2024/08/29 01:19 [entrez] PHST- 2024/07/24 00:00 [pmc-release] AID - medicina60081196 [pii] AID - medicina-60-01196 [pii] AID - 10.3390/medicina60081196 [doi] PST - epublish SO - Medicina (Kaunas). 2024 Jul 24;60(8):1196. doi: 10.3390/medicina60081196. PMID- 39202001 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240901 IS - 2075-4426 (Print) IS - 2075-4426 (Electronic) IS - 2075-4426 (Linking) VI - 14 IP - 8 DP - 2024 Jul 30 TI - Development of a User-Friendly Self-Screening Tool for Assessing Metabolic Syndrome Risk in Youths from Economically Challenged Regions. LID - 10.3390/jpm14080810 [doi] LID - 810 AB - BACKGROUND: Metabolic syndrome increases the risk of heart disease and diabetes. Early identification and management are crucial, especially in economically challenged regions with limited healthcare access. AIMS: To develop nomograms for individualized risk estimation for metabolic syndrome in young people from low-income regions. METHODS: We assessed 496 college students from two Brazilian cities with Gini indices /=0.70) and calibration (Hosmer-Lemeshow test, p > 0.05). In the external validation, we observed higher predictive capability for the A and B scores, while the C score had lower but still acceptable predictive ability. CONCLUSIONS: User-friendly self-reported data accurately predict metabolic syndrome among youths from economically challenging areas. FAU - Xavier, Jacqueline Fernandes de Sa AU - Xavier JFS AUID- ORCID: 0000-0002-1994-3530 AD - Health, Physical Activity and Behavior Research (HEALTHY-BRA) Group, Universidade Federal do Tocantins, Miracema do Tocantins 77650-000, Brazil. FAU - Feuerstein, Shirley C AU - Feuerstein SC AUID- ORCID: 0000-0003-4589-694X AD - Health, Physical Activity and Behavior Research (HEALTHY-BRA) Group, Universidade Federal do Tocantins, Miracema do Tocantins 77650-000, Brazil. FAU - De Moraes, Augusto Cesar Ferreira AU - De Moraes ACF AUID- ORCID: 0000-0002-5763-435X AD - Texas PARC-Texas Physical Activity Research Collaborative Lab, Michael and Susan Dell Center for Healthy Living, Department of Epidemiology, School of Public Health in Austin, The University of Texas Health Science Center at Houston, Austin, TX 78701, USA. FAU - de Oliveira, Tiago Almeida AU - de Oliveira TA AUID- ORCID: 0000-0003-4147-7721 AD - Statistic Department, State University of Paraiba, Campina Grande 58429-900, Brazil. FAU - da Silva Gomes, Evellyn Ravena AU - da Silva Gomes ER AD - Health, Physical Activity and Behavior Research (HEALTHY-BRA) Group, Universidade Federal do Tocantins, Miracema do Tocantins 77650-000, Brazil. AD - Instituto de Ensino Superior do Sul do Maranhao (IESMA/UNISULMA), Imperatriz 65907-070, Brazil. FAU - de Almeida Silva, Maria Isabela Alves AU - de Almeida Silva MIA AUID- ORCID: 0000-0002-2948-7364 AD - Health, Physical Activity and Behavior Research (HEALTHY-BRA) Group, Universidade Federal do Tocantins, Miracema do Tocantins 77650-000, Brazil. AD - Instituto de Ensino Superior do Sul do Maranhao (IESMA/UNISULMA), Imperatriz 65907-070, Brazil. FAU - de Oliveira, Luiz Fernando AU - de Oliveira LF AUID- ORCID: 0000-0002-6682-688X AD - Health, Physical Activity and Behavior Research (HEALTHY-BRA) Group, Universidade Federal do Tocantins, Miracema do Tocantins 77650-000, Brazil. FAU - de Carvalho, Heraclito Barbosa AU - de Carvalho HB AUID- ORCID: 0000-0002-7037-5655 AD - YCARE (Youth/Child and Cardiovascular Risk and Environmental) Research Group, School of Medicine, University of Sao Paulo, Sao Paulo 17012-900, Brazil. FAU - Marin, Kliver Antonio AU - Marin KA AD - Health, Physical Activity and Behavior Research (HEALTHY-BRA) Group, Universidade Federal do Tocantins, Miracema do Tocantins 77650-000, Brazil. FAU - Nascimento-Ferreira, Marcus Vinicius AU - Nascimento-Ferreira MV AUID- ORCID: 0000-0002-6344-1044 AD - Health, Physical Activity and Behavior Research (HEALTHY-BRA) Group, Universidade Federal do Tocantins, Miracema do Tocantins 77650-000, Brazil. LA - eng GR - 402391/2021-7/National Council for Scientific and Technological Development/ PT - Journal Article DEP - 20240730 PL - Switzerland TA - J Pers Med JT - Journal of personalized medicine JID - 101602269 PMC - PMC11355849 OTO - NOTNLM OT - disparities OT - lifestyle OT - metabolic health OT - nomogram COIS- The authors declare no conflicts of interest. EDAT- 2024/08/31 09:47 MHDA- 2024/08/31 09:48 PMCR- 2024/07/30 CRDT- 2024/08/29 01:16 PHST- 2024/06/21 00:00 [received] PHST- 2024/07/17 00:00 [revised] PHST- 2024/07/26 00:00 [accepted] PHST- 2024/08/31 09:48 [medline] PHST- 2024/08/31 09:47 [pubmed] PHST- 2024/08/29 01:16 [entrez] PHST- 2024/07/30 00:00 [pmc-release] AID - jpm14080810 [pii] AID - jpm-14-00810 [pii] AID - 10.3390/jpm14080810 [doi] PST - epublish SO - J Pers Med. 2024 Jul 30;14(8):810. doi: 10.3390/jpm14080810. PMID- 39201827 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240901 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 11 IP - 8 DP - 2024 Jul 25 TI - Regional Disparities in Growth Patterns of Children with Cerebral Palsy: A Comparative Analysis of Saudi Arabian, UK, and US Data. LID - 10.3390/children11080891 [doi] LID - 891 AB - AIM: In order to understand the global variations in the growth trajectories of cerebral palsy patients, this study aimed to compare the growth patterns of cerebral palsy patients in Saudi Arabi with United States and United Kingdom counterparts. METHOD: Anthropometric data from 107 participants with cerebral palsy in Saudi Arabia were collected, including age, gender, cerebral palsy type, Gross Motor Function Classification System level, birth weight, weight at assessment, height at assessment, body mass index, and head circumference at assessment. RESULTS: This study found discrepancies between the growth patterns of Saudi Arabian children with cerebral palsy and United Kingdom and the United States growth charts, particularly among those with severe cerebral palsy. Significant differences were observed in weight, height, and body mass index z-scores when comparing Saudi Arabian data with the United kingdom and United States reference data. INTERPRETATION: These findings emphasize the importance of validating growth charts across different populations to ensure accurate monitoring and clinical management of children with cerebral palsy. Additionally, this study highlights the need for region-specific growth references to better address the diverse needs of individuals with cerebral palsy worldwide. FAU - Alghadier, Mshari AU - Alghadier M AUID- ORCID: 0000-0003-3686-8074 AD - Department of Health and Rehabilitation Sciences, Prince Sattam bin Abdulaziz University, Alkharj 11942, Saudi Arabia. FAU - Basuodan, Reem M AU - Basuodan RM AD - Department of Rehabilitation Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia. FAU - Albesher, Reem A AU - Albesher RA AUID- ORCID: 0000-0002-4575-7117 AD - Department of Rehabilitation Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia. FAU - Waqas, Saadia AU - Waqas S AD - School of Health Sciences and Social Work, Griffith University, Nathan, QLD 4111, Australia. FAU - Suliman, Eman Misbah AU - Suliman EM AD - Children with Disability Association, Riyadh 12273, Saudi Arabia. FAU - Hassan, Mohammed AU - Hassan M AD - Children with Disability Association, Riyadh 12273, Saudi Arabia. LA - eng GR - KSRG-2023-475/King Salman Center for Disability Research/ PT - Journal Article DEP - 20240725 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC11352230 OTO - NOTNLM OT - Saudi Arabia OT - cerebral palsy OT - gross motor function classification system (GMFCS) OT - growth patterns OT - neurodevelopmental disorder COIS- The authors declare no conflicts of interest. EDAT- 2024/08/31 09:52 MHDA- 2024/08/31 09:53 PMCR- 2024/07/25 CRDT- 2024/08/29 01:15 PHST- 2024/06/22 00:00 [received] PHST- 2024/07/17 00:00 [revised] PHST- 2024/07/23 00:00 [accepted] PHST- 2024/08/31 09:53 [medline] PHST- 2024/08/31 09:52 [pubmed] PHST- 2024/08/29 01:15 [entrez] PHST- 2024/07/25 00:00 [pmc-release] AID - children11080891 [pii] AID - children-11-00891 [pii] AID - 10.3390/children11080891 [doi] PST - epublish SO - Children (Basel). 2024 Jul 25;11(8):891. doi: 10.3390/children11080891. PMID- 39201821 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240901 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 11 IP - 8 DP - 2024 Jul 23 TI - Exploring the Influence of Concurrent Nutritional Therapy on Children with Spinal Muscular Atrophy Receiving Nusinersen Treatment. LID - 10.3390/children11080886 [doi] LID - 886 AB - Background This study examines spinal muscular atrophy (SMA), a neuromuscular disease associated with malnutrition. Our goals are to assess how effectively screening tools can detect malnutrition and evaluate the impact of nutritional interventions on neurological outcomes, particularly motor functions. Methods Thirty-seven genetically diagnosed SMA patients (types 1, 2, and 3) under nusinersen therapy were included in the study. The nutritional status of these patients was assessed by using anthropometric measurements, including height for age (HFA), weight for height (WFH), and body mass index (BMI) before and after the study. Additionally, the risk of malnutrition was determined using screening tools, namely the Pediatric Yorkhill Malnutrition Score (PYMS) and the Screening Tool for the Assessment of Malnutrition in Pediatrics (STAMP). Nutritional counseling followed the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) guidelines and considered the patients' dietary history, including content and administration method. Motor functions were assessed by validated tests: the Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP-INTEND) and the Hammersmith Functional Motor Scale-Expanded (HFMSE). Result The study showed an improvement in HFA, by a change from -0.95 to -0.65 (p = 0.015). Conversely, BMI scores decreased from 0.08 to -0.54 (p = 0.015), while WFH and MUAC showed no significant alterations (p = 0.135, p = 0.307). Following nutritional interventions, HFMSE demonstrated a median increase from 29.5 to 30.5 (p = 0.023). Patients identified as being at high risk for malnutrition based on PYMS and STAMP belonged to the moderate-to-severe malnutrition group (BMI Z-score 2 (N = 279) but not observed in a child with a maximum BMI z score /=6 (M = 7.2, SD = 1.9), 43.9% (n = 43) of those queried to be autistic scored above clinical threshold (M = 5.2, SD = 2.5), and 6.5% (n = 4) of non-autistic individuals scored above clinical threshold (M = 2.8, SD = 1.8). Additionally, the AQ-10 satisfactorily discriminated between those with a known autism diagnosis and those who are not autistic across all age groups and sex. We conclude that the AQ-10, alongside a comprehensive clinical assessment and clinical judgment, is a useful screening tool that can support clinicians to identify appropriate onward referrals for autism assessments, aid clinical formulation, and consider appropriate adaptations and reasonable adjustments during ARFID interventions. CI - (c) 2024 International Society for Autism Research and Wiley Periodicals LLC. FAU - Archibald, Tanith AU - Archibald T AUID- ORCID: 0009-0008-6048-690X AD - Maudsley Centre for Child and Adolescent Eating Disorders, South London and Maudsley NHS Foundation Trust, London, UK. FAU - Willmott, Emma AU - Willmott E AUID- ORCID: 0000-0002-1482-1171 AD - Maudsley Centre for Child and Adolescent Eating Disorders, South London and Maudsley NHS Foundation Trust, London, UK. FAU - Kelly, Cate AU - Kelly C AUID- ORCID: 0009-0000-8714-4127 AD - Maudsley Centre for Child and Adolescent Eating Disorders, South London and Maudsley NHS Foundation Trust, London, UK. AD - Department of Clinical, Educational and Health Psychology, University College London, London, UK. FAU - Bradbury, Louise AU - Bradbury L AUID- ORCID: 0000-0002-2858-5560 AD - Maudsley Centre for Child and Adolescent Eating Disorders, South London and Maudsley NHS Foundation Trust, London, UK. FAU - Hugo, Pippa AU - Hugo P AUID- ORCID: 0009-0001-5332-2797 AD - Maudsley Centre for Child and Adolescent Eating Disorders, South London and Maudsley NHS Foundation Trust, London, UK. FAU - Bryant-Waugh, Rachel AU - Bryant-Waugh R AUID- ORCID: 0000-0002-7449-6059 AD - Maudsley Centre for Child and Adolescent Eating Disorders, South London and Maudsley NHS Foundation Trust, London, UK. AD - Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. LA - eng PT - Journal Article DEP - 20240826 PL - United States TA - Autism Res JT - Autism research : official journal of the International Society for Autism Research JID - 101461858 SB - IM MH - Humans MH - Adolescent MH - Male MH - Child MH - Female MH - Child, Preschool MH - Surveys and Questionnaires MH - *Avoidant Restrictive Food Intake Disorder MH - Autistic Disorder/diagnosis MH - Outpatients/statistics & numerical data MH - Reproducibility of Results OTO - NOTNLM OT - AQ-10 OT - ARFID OT - ASD OT - autism OT - autism screening OT - autism spectrum disorder OT - avoidant restrictive food intake disorder OT - eating disorders EDAT- 2024/08/27 09:48 MHDA- 2024/11/04 18:24 CRDT- 2024/08/27 02:33 PHST- 2024/05/17 00:00 [received] PHST- 2024/08/01 00:00 [accepted] PHST- 2024/11/04 18:24 [medline] PHST- 2024/08/27 09:48 [pubmed] PHST- 2024/08/27 02:33 [entrez] AID - 10.1002/aur.3220 [doi] PST - ppublish SO - Autism Res. 2024 Sep;17(9):1867-1875. doi: 10.1002/aur.3220. Epub 2024 Aug 26. PMID- 39187832 OWN - NLM STAT- MEDLINE DCOM- 20240827 LR - 20250203 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 Aug 26 TI - Associations of the planetary health diet index (PHDI) with asthma: the mediating role of body mass index. PG - 2305 LID - 10.1186/s12889-024-19856-1 [doi] LID - 2305 AB - BACKGROUND: Given the global shifts in environmental conditions and dietary habits, understanding the potential impact of dietary factors and body mass index (BMI) on respiratory diseases, including asthma, is paramount. Investigating these relationships can contribute to the formulation of more effective prevention strategies. The Planetary Health Diet Index (PHDI), a dietary scoring system that balances human health with environmental sustainability, underscores the importance of increasing the consumption of plant-based foods while reducing the intake of red meat, sugar, and highly processed foods. The objective of this study was to assess the association between PHDI and the prevalence of asthma and the mediation effect of BMI in a US general population. METHODS: This study utilized data from 32,388 participants in the National Health and Nutrition Examination Survey (NHANES) spanning from 2005 to 2018. Multivariate logistic regression and weighted quantile sum (WQS) regressions were employed to investigate the association between PHDI, individual nutrients, and asthma. Restricted cubic spline (RCS) analysis explored the linear or non-linear relationship between PHDI and asthma. Interaction analyses were conducted on subgroups to validate the findings. Mediation analysis was performed to examine the effect of BMI on the relationship between PHDI and asthma. RESULTS: There was a significant negative association between PHDI and asthma. After adjusting for covariates, for every 10-point increase in PHDI, there was a 4% decrease in the prevalence of asthma (P = 0.025). Moreover, as PHDI increased, there was a trend towards lower asthma prevalence (P for trend < 0.05). WQS analyses showed consistent associations (OR = 0.93, 95%CI: 0.88, 0.98), with Fiber, Vitamin C, and Protein significant factors. The dose-response curve indicated a linear association between PHDI and asthma, with higher PHDI associated with lower asthma prevalence. Additionally, BMI is significantly positively associated with asthma (P < 0.001), and BMI decreases as the PHDI increases (beta = -0.64, P < 0.001). Mediation analysis indicates that BMI significantly mediates the relationship between PHDI and asthma, with a mediation proportion of 33.85% (P < 0.001). CONCLUSION: The results of this study show a strong negative correlation between PHDI and the prevalence of asthma. In addition, BMI mediated this negative relationship. CI - (c) 2024. The Author(s). FAU - Huang, Shaoqun AU - Huang S AD - Department of Oncology Surgery, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou City, Fujian Province, China. FAU - He, Qiao AU - He Q AD - Graduate School of Tianjin, University of Traditional Chinese Medicine, Tianjin City, China. FAU - Wang, Xiaoxuan AU - Wang X AD - Graduate School of Tianjin, University of Traditional Chinese Medicine, Tianjin City, China. FAU - Choi, Seok AU - Choi S AD - Department of Physiology, College of Medicine, Chosun University, Gwangju, Korea. FAU - Gong, Hongyang AU - Gong H AD - Department of Physiology, College of Medicine, Chosun University, Gwangju, Korea. hygong@chosun.ac.kr. LA - eng PT - Journal Article DEP - 20240826 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - *Asthma/epidemiology MH - *Body Mass Index MH - Male MH - Female MH - *Nutrition Surveys MH - Adult MH - Middle Aged MH - United States/epidemiology MH - Young Adult MH - Adolescent MH - Prevalence MH - Diet, Healthy/statistics & numerical data MH - Diet/statistics & numerical data MH - Aged MH - Cross-Sectional Studies PMC - PMC11346270 OTO - NOTNLM OT - Asthma OT - Body mass index OT - Mediation analysis OT - NHANES OT - Planetary Health Diet Index COIS- The authors declare no competing interests. EDAT- 2024/08/27 09:50 MHDA- 2024/08/27 09:51 PMCR- 2024/08/26 CRDT- 2024/08/26 23:31 PHST- 2024/07/10 00:00 [received] PHST- 2024/08/22 00:00 [accepted] PHST- 2024/08/27 09:51 [medline] PHST- 2024/08/27 09:50 [pubmed] PHST- 2024/08/26 23:31 [entrez] PHST- 2024/08/26 00:00 [pmc-release] AID - 10.1186/s12889-024-19856-1 [pii] AID - 19856 [pii] AID - 10.1186/s12889-024-19856-1 [doi] PST - epublish SO - BMC Public Health. 2024 Aug 26;24(1):2305. doi: 10.1186/s12889-024-19856-1. PMID- 39184019 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240830 IS - 2055-2076 (Print) IS - 2055-2076 (Electronic) IS - 2055-2076 (Linking) VI - 10 DP - 2024 Jan-Dec TI - Data management plan and REDCap mobile data capture for a multi-country Household Air Pollution Intervention Network (HAPIN) trial. PG - 20552076241274217 LID - 10.1177/20552076241274217 [doi] LID - 20552076241274217 AB - BACKGROUND: Household air pollution (HAP) is a leading environmental risk factor accounting for about 1.6 million premature deaths mainly in low- and middle-income countries (LMICs). However, no multicounty randomized controlled trials have assessed the effect of liquefied petroleum gas (LPG) stove intervention on HAP and maternal and child health outcomes. The Household Air Pollution Intervention Network (HAPIN) was the first to assess this by implementing a common protocol in four LMICs. OBJECTIVE: This manuscript describes the implementation of the HAPIN data management protocol via Research Electronic Data Capture (REDCap) used to collect over 50 million data points in more than 4000 variables from 80 case report forms (CRFs). METHODS: We recruited 800 pregnant women in each study country (Guatemala, India, Peru, and Rwanda) who used biomass fuels in their households. Households were randomly assigned to receive LPG stoves and 18 months of free LPG supply (intervention) or to continue using biomass fuels (control). Households were followed for 18 months and assessed for primary health outcomes: low birth weight, severe pneumonia, and stunting. The HAPIN Data Management Core (DMC) implemented identical REDCap projects for each study site using shared variable names and timelines in local languages. Field staff collected data offline using tablets on the REDCap Mobile Application. RESULTS: Utilizing the REDCap application allowed the HAPIN DMC to collect and store data securely, access data (near real-time), create reports, perform quality control, update questionnaires, and provide timely feedback to local data management teams. Additional REDCap functionalities (e.g. scheduling, data validation, and barcode scanning) supported the study. CONCLUSIONS: While the HAPIN trial experienced some challenges, REDCap effectively met HAPIN study goals, including quality data collection and timely reporting and analysis on this important global health trial, and supported more than 40 peer-reviewed scientific publications to date. CI - (c) The Author(s) 2024. FAU - Jabbarzadeh, Shirin AU - Jabbarzadeh S AUID- ORCID: 0009-0008-2096-2430 AD - Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA. FAU - Jaacks, Lindsay M AU - Jaacks LM AD - Global Academy of Agriculture and Food Systems, University of Edinburgh, Edinburgh, UK. FAU - Lovvorn, Amy AU - Lovvorn A AD - Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. FAU - Chen, Yunyun AU - Chen Y AD - Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA. FAU - Wang, Jiantong AU - Wang J AD - Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA. FAU - Elon, Lisa AU - Elon L AD - Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA. FAU - Nizam, Azhar AU - Nizam A AD - Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA. FAU - Aravindalochanan, Vigneswari AU - Aravindalochanan V AUID- ORCID: 0000-0001-5722-8741 AD - Department of Environmental Health Engineering, Sri Ramachandra Institute for Higher Education and Research (Deemed University), Chennai, India. FAU - Ntivuguruzwa, Jean de Dieu AU - Ntivuguruzwa JD AD - Eagle Research Centre Limited, Kigali, Rwanda. FAU - Willams, Kendra N AU - Willams KN AD - Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. FAU - Ramirez, Alexander AU - Ramirez A AD - Center for Health Studies, Universidad del Valle de Guatemala, Guatemala City, Guatemala. RINGGOLD: 34850 FAU - Johnson, Michael A AU - Johnson MA AD - Berkeley Air Monitoring Group, Berkeley, CA, USA. FAU - Pillarisetti, Ajay AU - Pillarisetti A AD - Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA. FAU - Gurusamy, Thangavel AU - Gurusamy T AD - Department of Environmental Health Engineering, Sri Ramachandra Institute for Higher Education and Research (Deemed University), Chennai, India. FAU - Rosa, Ghislaine AU - Rosa G AD - University of Liverpool, Liverpool, England. RINGGOLD: 4591 FAU - Diaz-Artiga, Anaite AU - Diaz-Artiga A AD - Center for Health Studies, Universidad del Valle de Guatemala, Guatemala City, Guatemala. RINGGOLD: 34850 FAU - Romero, Juan C AU - Romero JC AUID- ORCID: 0000-0002-3474-4951 AD - Center for Health Studies, Universidad del Valle de Guatemala, Guatemala City, Guatemala. RINGGOLD: 34850 FAU - Balakrishnan, Kalpana AU - Balakrishnan K AD - Department of Environmental Health Engineering, Sri Ramachandra Institute for Higher Education and Research (Deemed University), Chennai, India. FAU - Checkley, William AU - Checkley W AD - Center for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, Baltimore, MA, USA. FAU - Peel, Jennifer L AU - Peel JL AD - Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA. RINGGOLD: 3447 FAU - Clasen, Thomas F AU - Clasen TF AD - Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. FAU - Waller, Lance A AU - Waller LA AD - Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA. LA - eng GR - R01 CE002981/CE/NCIPC CDC HHS/United States GR - UM1 HL134590/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20240821 PL - United States TA - Digit Health JT - Digital health JID - 101690863 PMC - PMC11342436 OTO - NOTNLM OT - Data collection OT - HAPIN OT - REDCap OT - REDCap mobile app OT - data management OT - digital data capture OT - household air pollution OT - multi-country COIS- The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2024/08/26 12:39 MHDA- 2024/08/26 12:40 PMCR- 2024/08/21 CRDT- 2024/08/26 04:58 PHST- 2023/11/19 00:00 [received] PHST- 2024/06/25 00:00 [accepted] PHST- 2024/08/26 12:40 [medline] PHST- 2024/08/26 12:39 [pubmed] PHST- 2024/08/26 04:58 [entrez] PHST- 2024/08/21 00:00 [pmc-release] AID - 10.1177_20552076241274217 [pii] AID - 10.1177/20552076241274217 [doi] PST - epublish SO - Digit Health. 2024 Aug 21;10:20552076241274217. doi: 10.1177/20552076241274217. eCollection 2024 Jan-Dec. PMID- 39183741 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240919 IS - 2398-502X (Print) IS - 2398-502X (Electronic) IS - 2398-502X (Linking) VI - 8 DP - 2023 TI - Understanding the epidemiology of iNTS disease in Africa in preparation for future iNTS- vaccine studies in endemic countries: Seroepidemiology in Africa of iNTS (SAiNTS) Study Protocol: Malawi site [Version 9.0]. PG - 27 LID - 10.12688/wellcomeopenres.18054.2 [doi] LID - 27 AB - BACKGROUND: Non-typhoidal Salmonella (NTS) are a major cause of bloodstream infections amongst children in sub-Saharan Africa. A clear understanding of the seroepidemiology and correlates of protection for invasive NTS (iNTS) in relation to key risk factors (malaria, anaemia, malnutrition) in children in Africa is needed to inform strategies for disease control including vaccine implementation. METHODOLOGY: The SAiNTS study is a prospective community cohort study with paired serology samples from 2500 Malawian children 0-5 years at baseline and three months to measure age-stratified acquisition of lipopolysaccharide (LPS) O-antigen antibody (IgG) and serum bactericidal activity to the main serovars causing iNTS ( Salmonella Typhimurium and S. Enteritidis). Children are selected from mapped and censused randomly selected households in Chikwawa, Malawi; an area with substantial malaria burden. The sampling framework is set within a malaria vaccination (RTS,S/ AS01) phase 4 cluster randomized trial, known as the Epidemiology Study of Malaria Transmission Intensity (EPI-MAL), allowing exploration of the impact of malaria vaccination on acquisition of immunity to NTS. Risk factor data for invasive disease will be collected using rapid diagnostic tests for malaria and anaemia, anthropometry for malnutrition, and a validated questionnaire for indicators of socioeconomic status, water and sanitation. All data will be recorded through electronic case report forms using the REDCap and the Open Data Kit (ODK) platforms. Stool sample analysis includes NTS culture and pan-Salmonella polymerase chain reaction to assess enteric exposure and biomarkers of environmental enteric dysfunction. Cases with iNTS disease will be followed up for comparison with community controls. CONCLUSIONS: The final cohort of 2500 children will allow investigation into the impact of risk factors for iNTS on the acquisition of immunity in children 0-5 years in an endemic setting, including comparisons to partner seroepidemiology studies in three other sub-Saharan African sites (1000 children per site). The data generated will be key to informing iNTS disease control measures including targeted risk factor interventions and vaccine implementation through investigation of correlates of protection and identifying windows of immune susceptibility in at-risk populations. CI - Copyright: (c) 2024 Dale H et al. FAU - Dale, Helen AU - Dale H AUID- ORCID: 0000-0002-4171-1226 AD - Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, Merseyside, L69 3GF, UK. AD - Clinical Research, Malawi-Liverpool-Wellcome Clinical Research-Program, Blantyre, Southern Region, PO Box 30096, Malawi. FAU - Chirwa, Esmeda AU - Chirwa E AD - Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, Merseyside, L69 3GF, UK. AD - Clinical Research, Malawi-Liverpool-Wellcome Clinical Research-Program, Blantyre, Southern Region, PO Box 30096, Malawi. FAU - Patel, Priyanka AU - Patel P AD - Clinical Research, Malawi-Liverpool-Wellcome Clinical Research-Program, Blantyre, Southern Region, PO Box 30096, Malawi. FAU - Makuta, Georgina AU - Makuta G AD - Clinical Research, Malawi-Liverpool-Wellcome Clinical Research-Program, Blantyre, Southern Region, PO Box 30096, Malawi. FAU - Mwakiseghile, Felistas AU - Mwakiseghile F AD - Clinical Research, Malawi-Liverpool-Wellcome Clinical Research-Program, Blantyre, Southern Region, PO Box 30096, Malawi. FAU - Misiri, Theresa AU - Misiri T AD - Clinical Research, Malawi-Liverpool-Wellcome Clinical Research-Program, Blantyre, Southern Region, PO Box 30096, Malawi. FAU - Kadwala, Innocent AU - Kadwala I AD - Clinical Research, Malawi-Liverpool-Wellcome Clinical Research-Program, Blantyre, Southern Region, PO Box 30096, Malawi. FAU - Mbewe, Maurice AU - Mbewe M AD - Clinical Research, Malawi-Liverpool-Wellcome Clinical Research-Program, Blantyre, Southern Region, PO Box 30096, Malawi. FAU - Banda, Happy AU - Banda H AD - Clinical Research, Malawi-Liverpool-Wellcome Clinical Research-Program, Blantyre, Southern Region, PO Box 30096, Malawi. FAU - Silungwe, Niza AU - Silungwe N AD - Clinical Research, Malawi-Liverpool-Wellcome Clinical Research-Program, Blantyre, Southern Region, PO Box 30096, Malawi. FAU - Chizani, Kenneth AU - Chizani K AD - Clinical Research, Malawi-Liverpool-Wellcome Clinical Research-Program, Blantyre, Southern Region, PO Box 30096, Malawi. FAU - Kambiya, Paul AU - Kambiya P AD - Clinical Research, Malawi-Liverpool-Wellcome Clinical Research-Program, Blantyre, Southern Region, PO Box 30096, Malawi. FAU - Henrion, Marc AU - Henrion M AUID- ORCID: 0000-0003-1242-839X AD - Clinical Research, Malawi-Liverpool-Wellcome Clinical Research-Program, Blantyre, Southern Region, PO Box 30096, Malawi. FAU - French, Neil AU - French N AD - Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, Merseyside, L69 3GF, UK. FAU - Nyirenda, Tonny AU - Nyirenda T AD - Pathogy Department, Kamuzu University of Health Sciences, Blantyre, Southern Region, Private Bag 360, Malawi. FAU - Gordon, Melita AU - Gordon M AUID- ORCID: 0000-0002-0629-0884 AD - Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, Merseyside, L69 3GF, UK. AD - Clinical Research, Malawi-Liverpool-Wellcome Clinical Research-Program, Blantyre, Southern Region, PO Box 30096, Malawi. CN - Vacc-iNTS LA - eng GR - WT_/Wellcome Trust/United Kingdom PT - Journal Article DEP - 20240821 PL - England TA - Wellcome Open Res JT - Wellcome open research JID - 101696457 PMC - PMC11344207 OTO - NOTNLM OT - iNTS; immunoepidemiology; susceptibility; malaria; children OT - non-typhoidal salmonella COIS- No competing interests were disclosed. EDAT- 2024/08/26 12:39 MHDA- 2024/08/26 12:40 PMCR- 2024/08/21 CRDT- 2024/08/26 04:54 PHST- 2024/04/25 00:00 [accepted] PHST- 2024/08/26 12:40 [medline] PHST- 2024/08/26 12:39 [pubmed] PHST- 2024/08/26 04:54 [entrez] PHST- 2024/08/21 00:00 [pmc-release] AID - 10.12688/wellcomeopenres.18054.2 [doi] PST - epublish SO - Wellcome Open Res. 2024 Aug 21;8:27. doi: 10.12688/wellcomeopenres.18054.2. eCollection 2023. PMID- 39182263 OWN - NLM STAT- MEDLINE DCOM- 20240913 LR - 20260628 IS - 1873-2380 (Electronic) IS - 0021-9290 (Linking) VI - 175 DP - 2024 Oct TI - Comparing the effectiveness of robotic plantarflexion resistance and biofeedback between overground and treadmill walking. PG - 112282 LID - S0021-9290(24)00360-9 [pii] LID - 10.1016/j.jbiomech.2024.112282 [doi] AB - Individuals with diminished walking performance caused by neuromuscular impairments often lack plantar flexion muscle activity. Robotic devices have been developed to address these issues and increase walking performance. While these devices have shown promise in their ability to increase musculature engagement of the lower limbs when used on a treadmill, most have not been developed or validated for overground walking and community use. Overground walking may limit the effectiveness of robotic devices due to differences in gait characteristics between walking terrains and reduced user engagement. The purpose of this study was to validate our multimodal robotic gait training system for overground walking in individuals with neuromuscular gait impairments. This untethered wearable robotic device can provide an ankle resistive torque proportional to the users' biological ankle torque. The device can also provide audio biofeedback based on users' plantar pressure intending to increase ankle power and muscle activity of the plantar flexors. Seven individuals with cerebral palsy participated. Participants walked overground and on a treadmill with our robotic gait training system in a single testing session. Results showed all seven participants to increase peak plantar flexor muscle activity, 10.3% on average, when walking with the gait trainer overground compared to treadmill. When compared to typical baseline overground walking, overground gait trainer use caused individuals to have slightly less knee joint excursion (3 degrees ) and moderately more ankle joint excursion (7 degrees ). This work supports our vision of using the wearable robotic device as a gait aid and rehabilitation tool in the home and community settings. CI - Copyright (c) 2024. Published by Elsevier Ltd. FAU - Bowersock, Collin D AU - Bowersock CD AD - Department of Mechanical Engineering, Northern Arizona University, Flagstaff, AZ, United States. Electronic address: collin.bowersock@nau.edu. FAU - Lerner, Zachary F AU - Lerner ZF AD - Department of Mechanical Engineering, Northern Arizona University, Flagstaff, AZ, United States; College of Medicine - Phoenix, University of Arizona, Phoenix, AZ, United States. Electronic address: zachary.lerner@nau.edu. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240816 PL - United States TA - J Biomech JT - Journal of biomechanics JID - 0157375 SB - IM MH - Humans MH - Male MH - *Walking/physiology MH - Female MH - *Robotics/instrumentation/methods MH - Biofeedback, Psychology/methods/instrumentation MH - Adult MH - Ankle Joint/physiology/physiopathology MH - Gait/physiology MH - Cerebral Palsy/physiopathology/rehabilitation MH - Muscle, Skeletal/physiology/physiopathology MH - Ankle/physiology MH - Adolescent MH - Gait Disorders, Neurologic/rehabilitation/physiopathology MH - Young Adult MH - Biomechanical Phenomena MH - Exercise Test/methods OTO - NOTNLM OT - Exoskeleton OT - Plantar pressure biofeedback OT - Resistive gait training COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Z. F. Lerner is a co-founder with shareholder interest in Biomotum, Inc., a spinoff company from his laboratory that is seeking to commercialize the device used in this study. He also has intellectual property inventorship rights covering aspects of the design and control of the device used in this study. EDAT- 2024/08/26 12:39 MHDA- 2024/09/14 10:42 CRDT- 2024/08/25 18:01 PHST- 2024/01/25 00:00 [received] PHST- 2024/07/22 00:00 [revised] PHST- 2024/08/16 00:00 [accepted] PHST- 2024/09/14 10:42 [medline] PHST- 2024/08/26 12:39 [pubmed] PHST- 2024/08/25 18:01 [entrez] AID - S0021-9290(24)00360-9 [pii] AID - 10.1016/j.jbiomech.2024.112282 [doi] PST - ppublish SO - J Biomech. 2024 Oct;175:112282. doi: 10.1016/j.jbiomech.2024.112282. Epub 2024 Aug 16. PMID- 39181203 OWN - NLM STAT- MEDLINE DCOM- 20241211 LR - 20241211 IS - 2059-7762 (Electronic) IS - 2059-7754 (Linking) VI - 9 IP - 6 DP - 2024 Dec TI - Development and validation of a novel method for assessing physical activity profiles after anterior cruciate ligament reconstruction: The Sports and Physical Activity scale. PG - 100312 LID - S2059-7754(24)00159-7 [pii] LID - 10.1016/j.jisako.2024.100312 [doi] AB - OBJECTIVES: To describe and evaluate the preliminary validity of a novel scoring system for assessing the physical activity of patients after anterior cruciate ligament (ACL) reconstruction. METHODS: The Sports and Physical Activity (SPA) scale consists of thirty options of sports and physical activities, followed by four frequency options for each option selected. Factors used to develop the scoring system were frequency of participation and intensity of the sports or physical activities. Possible scores ranged from a low of 0 to a high of 24. The scale was assessed for validity and responsiveness. RESULTS: The study cohort included 418 primary ACL reconstructed patients 2 years after surgery, and a subgroup of 183 patient 5 years after surgery. The mean and median SPA scores for the cohort were 12.35 ( ​+/- ​6.95) and 12, respectively. There was no statistically significant difference between the scores of men and women (U ​= ​21,541.0, p ​= ​0.921). The SPA scale had a small but statistically significant inverse correlation with age (r(s) ​= ​-0.2, p = <0.001), indicating divergent validity. Patients who had returned to sport had a statistically significantly higher score (U ​= ​21593.5, p = <0.001), and there was a statistically significant difference between scores of the three current sports status groups (H ​= ​19.99, p value = <0.001) indicating convergent validity. Construct validity was indicated with a statistically significant correlation with the Marx scale (r(s) ​= ​0.422, p value= <0.001). In a subgroup (n ​= ​183) of the patient sample, comparison between scores at 2-years (13.27 ​+/- ​7.02) and 5-years (12.11 ​+/- ​7.88) found a statistically significant decline (p= <0.001). However, this decline was smaller than the decline seen in the Marx score between 2 and 5 years (11.11 ​+/- ​4.07 and 9.30 ​+/- ​4.52 p= <0.001). CONCLUSION: Preliminary validity was found for the SPA scale. Women and men were found to be participating in a similar amount of activity 2 years post ACL reconstruction, despite return to sport differences between men and women being well documented. The scores of the SPA scale showed a statistically significant decrease over time with a negligible effect size. LEVEL OF EVIDENCE: III. CI - Copyright (c) 2024 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Klemm, Haydn J AU - Klemm HJ AD - OrthoSport Victoria, Richmond, Victoria, Australia; La Trobe University, Bundoora, Victoria, Australia. FAU - Webster, Kate E AU - Webster KE AD - La Trobe University, Bundoora, Victoria, Australia. Electronic address: k.webster@latrobe.edu.au. FAU - Devitt, Brian M AU - Devitt BM AD - OrthoSport Victoria, Richmond, Victoria, Australia. FAU - Norsworthy, Cameron J AU - Norsworthy CJ AD - OrthoSport Victoria, Richmond, Victoria, Australia. FAU - Whitehead, Timothy S AU - Whitehead TS AD - OrthoSport Victoria, Richmond, Victoria, Australia. FAU - Feller, Julian A AU - Feller JA AD - OrthoSport Victoria, Richmond, Victoria, Australia; La Trobe University, Bundoora, Victoria, Australia. LA - eng PT - Journal Article PT - Validation Study DEP - 20240823 PL - England TA - J ISAKOS JT - Journal of ISAKOS : joint disorders & orthopaedic sports medicine JID - 101680867 SB - IM MH - Humans MH - *Anterior Cruciate Ligament Reconstruction/methods MH - Female MH - Male MH - Adult MH - *Exercise MH - *Anterior Cruciate Ligament Injuries/surgery MH - Return to Sport MH - Reproducibility of Results MH - Adolescent MH - Young Adult MH - Surveys and Questionnaires MH - Sports MH - Cohort Studies MH - Middle Aged OTO - NOTNLM OT - ACL reconstruction OT - Physical activity assessment OT - Return to sport COIS- Declaration of competing interest None declared. EDAT- 2024/08/26 12:41 MHDA- 2024/12/12 00:24 CRDT- 2024/08/24 19:25 PHST- 2024/06/24 00:00 [received] PHST- 2024/08/15 00:00 [revised] PHST- 2024/08/17 00:00 [accepted] PHST- 2024/12/12 00:24 [medline] PHST- 2024/08/26 12:41 [pubmed] PHST- 2024/08/24 19:25 [entrez] AID - S2059-7754(24)00159-7 [pii] AID - 10.1016/j.jisako.2024.100312 [doi] PST - ppublish SO - J ISAKOS. 2024 Dec;9(6):100312. doi: 10.1016/j.jisako.2024.100312. Epub 2024 Aug 23. PMID- 39179109 OWN - NLM STAT- MEDLINE DCOM- 20240909 LR - 20260526 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 202 DP - 2024 Nov 1 TI - Individual and environmental correlates of tap water consumption among adolescents in Canada. PG - 107645 LID - S0195-6663(24)00448-3 [pii] LID - 10.1016/j.appet.2024.107645 [doi] AB - The study objective was to identify correlates of tap water consumption among adolescents. French-speaking adolescents from the province of Quebec (Canada) were recruited in person and online from March to July 2023 using diverse recruitment strategies. Water consumption was measured using the validated French version of a questionnaire specifically designed to measure adolescents' beverage intake. Participants answered an online survey on their attitude towards tap and bottled water which also measured individual and environmental factors that can influence tap water consumption. A total of 218 adolescents (14-17 years; 55.5% female) completed the survey. On average, 79.2% of adolescents' water intake came from tap and 33.5% of them consumed exclusively tap water. Thinking that bottled water is more convenient than tap water was a significant correlate of adolescents' tap water consumption (OR = 0.70; 95% CI: 0.51, 0.95; p = 0.0219). Adolescents who believed that bottled water is more convenient than tap water were less likely to consume exclusively tap water. Public health interventions aimed at promoting adolescents' tap water should strive to make tap water intake be perceived as convenient as bottled water, such as encouraging teenagers to always carry along a reusable water bottle, installing drinking fountains in popular public areas, and increasing the visibility of such fountains. CI - Copyright (c) 2024 Elsevier Ltd. All rights reserved. FAU - Vezina-Im, Lydi-Anne AU - Vezina-Im LA AD - VITAM - Centre de Recherche en Sante Durable, Centre Integre Universitaire de Sante et de Services Sociaux (CIUSSS) de La Capitale-Nationale, 2480, Chemin de La Canardiere Quebec, Quebec, Canada, G1J 2G1; Departement des Sciences de La Sante, Universite Du Quebec a Rimouski (UQAR), Campus de Levis, 1595 Boulevard Alphonse-Desjardins, Levis, Quebec, Canada, G6V 0A6; Centre de Recherche Du Centre Integre de Sante et de Services Sociaux (CISSS) de Chaudiere-Appalaches, 143 Rue Wolfe, Levis, Quebec, Canada, G6V 3Z1; Collectif de Recherche sur La Sante en Region, 1595 Boulevard Alphonse-Desjardins, Levis, Quebec, Canada, G6V 0A6. Electronic address: Lydi-Anne.Vezina-Im.1@ulaval.ca. FAU - Beaulieu, Dominique AU - Beaulieu D AD - VITAM - Centre de Recherche en Sante Durable, Centre Integre Universitaire de Sante et de Services Sociaux (CIUSSS) de La Capitale-Nationale, 2480, Chemin de La Canardiere Quebec, Quebec, Canada, G1J 2G1; Departement des Sciences de La Sante, Universite Du Quebec a Rimouski (UQAR), Campus de Levis, 1595 Boulevard Alphonse-Desjardins, Levis, Quebec, Canada, G6V 0A6; Centre de Recherche Du Centre Integre de Sante et de Services Sociaux (CISSS) de Chaudiere-Appalaches, 143 Rue Wolfe, Levis, Quebec, Canada, G6V 3Z1; Collectif de Recherche sur La Sante en Region, 1595 Boulevard Alphonse-Desjardins, Levis, Quebec, Canada, G6V 0A6; Axe Sante des Populations et Pratiques Optimales en Sante, Centre de Recherche Du CHU de Quebec, 2400 Avenue D'Estimauville, Quebec, Quebec, Canada, G1E 6W2. Electronic address: Dominique_Beaulieu@uqar.ca. FAU - Turcotte, Stephane AU - Turcotte S AD - Centre de Recherche Du Centre Integre de Sante et de Services Sociaux (CISSS) de Chaudiere-Appalaches, 143 Rue Wolfe, Levis, Quebec, Canada, G6V 3Z1. Electronic address: Stephane_Turcotte@ssss.gouv.qc.ca. FAU - Turcotte, Anne-Frederique AU - Turcotte AF AD - Centre de Recherche Du Centre Integre de Sante et de Services Sociaux (CISSS) de Chaudiere-Appalaches, 143 Rue Wolfe, Levis, Quebec, Canada, G6V 3Z1. Electronic address: Anne-frederique.turcotte.cisssca@ssss.gouv.qc.ca. FAU - Lessard, Lily AU - Lessard L AD - Departement des Sciences de La Sante, Universite Du Quebec a Rimouski (UQAR), Campus de Levis, 1595 Boulevard Alphonse-Desjardins, Levis, Quebec, Canada, G6V 0A6; Centre de Recherche Du Centre Integre de Sante et de Services Sociaux (CISSS) de Chaudiere-Appalaches, 143 Rue Wolfe, Levis, Quebec, Canada, G6V 3Z1; Collectif de Recherche sur La Sante en Region, 1595 Boulevard Alphonse-Desjardins, Levis, Quebec, Canada, G6V 0A6; Chaire Interdisciplinaire sur La Sante et Les Services Sociaux pour Les Populations Rurales, 1595 Boulevard Alphonse-Desjardins, Levis, Quebec, Canada, G6V 0A6. Electronic address: Lily_lessard@uqar.ca. FAU - Delisle-Martel, Joannie AU - Delisle-Martel J AD - Departement des Sciences de La Sante, Universite Du Quebec a Rimouski (UQAR), Campus de Levis, 1595 Boulevard Alphonse-Desjardins, Levis, Quebec, Canada, G6V 0A6; Centre de Recherche Du Centre Integre de Sante et de Services Sociaux (CISSS) de Chaudiere-Appalaches, 143 Rue Wolfe, Levis, Quebec, Canada, G6V 3Z1; Collectif de Recherche sur La Sante en Region, 1595 Boulevard Alphonse-Desjardins, Levis, Quebec, Canada, G6V 0A6. Electronic address: Joannie_delisle-martel@uqar.ca. FAU - Boucher, Danielle AU - Boucher D AD - Departement des Sciences de La Sante, Universite Du Quebec a Rimouski (UQAR), Campus de Levis, 1595 Boulevard Alphonse-Desjardins, Levis, Quebec, Canada, G6V 0A6; Centre de Recherche Du Centre Integre de Sante et de Services Sociaux (CISSS) de Chaudiere-Appalaches, 143 Rue Wolfe, Levis, Quebec, Canada, G6V 3Z1; Collectif de Recherche sur La Sante en Region, 1595 Boulevard Alphonse-Desjardins, Levis, Quebec, Canada, G6V 0A6. Electronic address: Danielle_Boucher01@uqar.ca. FAU - Labbe, Valerie AU - Labbe V AD - CHAU-Hotel-Dieu de Levis, 143 Rue Wolfe, Levis, Quebec, Canada, G6V 3Z1. Electronic address: v_labbe2000@yahoo.ca. FAU - Gingras, Mariane AU - Gingras M AD - Direction de Sante Publique, CISSS de Chaudiere-Appalaches, 55, Rue Du Mont-Marie, Levis, Quebec, Canada, G6V 0B8. Electronic address: Mariane.gingras.cisssca@ssss.gouv.qc.ca. LA - eng PT - Journal Article DEP - 20240822 PL - England TA - Appetite JT - Appetite JID - 8006808 RN - 0 (Drinking Water) SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - Quebec MH - *Drinking Water MH - Surveys and Questionnaires MH - Drinking MH - Underage Drinking/psychology/statistics & numerical data MH - Adolescent Behavior/psychology OTO - NOTNLM OT - Adolescent OT - Adolescent behavior OT - Drinking water OT - Environment and public health OT - Tap water COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Lydi-Anne Vezina-Im reports financial support was provided by the Centre integre de sante et de services sociaux (CISSS) de Chaudiere-Appalaches. Lydi-Anne Vezina-Im reports financial support was provided by the Fondation de l'Hotel-Dieu de Levis. Dominique Beaulieu reports financial support was provided by the Collectif de recherche sur la sante en region. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/08/24 16:44 MHDA- 2024/09/10 00:43 CRDT- 2024/08/23 19:26 PHST- 2024/06/27 00:00 [received] PHST- 2024/08/19 00:00 [revised] PHST- 2024/08/20 00:00 [accepted] PHST- 2024/09/10 00:43 [medline] PHST- 2024/08/24 16:44 [pubmed] PHST- 2024/08/23 19:26 [entrez] AID - S0195-6663(24)00448-3 [pii] AID - 10.1016/j.appet.2024.107645 [doi] PST - ppublish SO - Appetite. 2024 Nov 1;202:107645. doi: 10.1016/j.appet.2024.107645. Epub 2024 Aug 22. PMID- 39174966 OWN - NLM STAT- MEDLINE DCOM- 20240823 LR - 20250131 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 Aug 22 TI - Knowledge and willingness to donate kidney for transplantation among general population in Saudi Arabia. PG - 2277 LID - 10.1186/s12889-024-19766-2 [doi] LID - 2277 AB - INTRODUCTION: Kidney transplantation is the preferred treatment for end-stage renal disease (ESRD), offering a superior quality of life and extended survival compared to other renal replacement therapies. As the number of ESRD patients grows, so does the demand for organ transplants. The prevalence of ESRD is anticipated to escalate further due to the rising rates of diabetes mellitus (DM), hypertension (HTN), and obesity. Organ donation, particularly from living donors, remains the main source of transplants in the region, despite the notable underutilization of potential deceased donors' organs. The objective of this research is to assess the level of knowledge, attitudes, and willingness to donate kidneys among the general population, a pivotal step in addressing the organ shortage crisis. METHODS: This cross-sectional study was conducted in the Aseer region of Saudi Arabia using a previously validated questionnaire. The questionnaire collected demographic data and insights into general attitudes, knowledge, and beliefs about organ donation. Logistic regression was used to identify predictors of knowledge and willingness to donate. RESULTS: The study involved 705 participants, predominantly young adults with a high level of education. Awareness of kidney donation was high, and knowledge about donation was broad, especially regarding religious permissibility and awareness of the donor registry. However, only 25% expressed willingness to donate their kidneys, and a 4% were already registered as donors. Furthermore, higher educational level was not associated with higher odds of knowledge or willingness to donate. CONCLUSION: Despite the considerable awareness, actual donor registration rates were low, highlighting the necessity for targeted educational interventions and a deeper understanding of the cultural and socioeconomic barriers that exist. CI - (c) 2024. The Author(s). FAU - Alshehri, Mohammed AU - Alshehri M AD - Nephrology Section, Internal Medicine Department, College of Medicine, King Khalid University, Abha, 61421, Saudi Arabia. Mohd.shehri@gmail.com. FAU - Tawhari, Ibrahim AU - Tawhari I AD - Nephrology Section, Internal Medicine Department, College of Medicine, King Khalid University, Abha, 61421, Saudi Arabia. FAU - Alqahtani, Thekra S AU - Alqahtani TS AD - Medical Intern at College of Medicine, King Khalid University, Abha, 61421, Saudi Arabia. FAU - Alqahtani, Alhanouf Y AU - Alqahtani AY AD - Medical Intern at College of Medicine, King Khalid University, Abha, 61421, Saudi Arabia. FAU - Al Jallal, Marwah S AU - Al Jallal MS AD - Medical Intern at College of Medicine, King Khalid University, Abha, 61421, Saudi Arabia. FAU - Asiri, Ghufran B AU - Asiri GB AD - Medical Intern at College of Medicine, King Khalid University, Abha, 61421, Saudi Arabia. FAU - Alshahrani, Maymunah A AU - Alshahrani MA AD - Medical Intern at College of Medicine, King Khalid University, Abha, 61421, Saudi Arabia. FAU - Majrashi, Maryam A AU - Majrashi MA AD - Medical Intern at College of Medicine, King Khalid University, Abha, 61421, Saudi Arabia. FAU - Khuzayyim, Ahmed A AU - Khuzayyim AA AD - Medical Intern at College of Medicine, King Khalid University, Abha, 61421, Saudi Arabia. FAU - Albishri, Fai D AU - Albishri FD AD - Medical Intern at College of Medicine, King Khalid University, Abha, 61421, Saudi Arabia. FAU - Alshahrani, Wajan A AU - Alshahrani WA AD - Medical Intern at College of Medicine, King Khalid University, Abha, 61421, Saudi Arabia. LA - eng GR - RGP.1/197/44/Deanship of Scientific Research, King Khalid University/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240822 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Male MH - Female MH - Saudi Arabia MH - Cross-Sectional Studies MH - Adult MH - *Kidney Transplantation/psychology MH - *Health Knowledge, Attitudes, Practice MH - Middle Aged MH - Young Adult MH - *Tissue and Organ Procurement/statistics & numerical data MH - Surveys and Questionnaires MH - Adolescent MH - Tissue Donors/psychology/statistics & numerical data PMC - PMC11340056 OTO - NOTNLM OT - Donor education OT - Organ transplantation OT - Public awareness OT - Saudi Arabia OT - Transplantation ethics COIS- The authors declare no competing interests. EDAT- 2024/08/23 00:43 MHDA- 2024/08/23 06:42 PMCR- 2024/08/22 CRDT- 2024/08/22 23:43 PHST- 2024/02/24 00:00 [received] PHST- 2024/08/12 00:00 [accepted] PHST- 2024/08/23 06:42 [medline] PHST- 2024/08/23 00:43 [pubmed] PHST- 2024/08/22 23:43 [entrez] PHST- 2024/08/22 00:00 [pmc-release] AID - 10.1186/s12889-024-19766-2 [pii] AID - 19766 [pii] AID - 10.1186/s12889-024-19766-2 [doi] PST - epublish SO - BMC Public Health. 2024 Aug 22;24(1):2277. doi: 10.1186/s12889-024-19766-2. PMID- 39173908 OWN - NLM STAT- MEDLINE DCOM- 20240925 LR - 20260724 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 63 DP - 2024 Oct TI - Macronutrient quality and its association with micronutrient adequacy in children. PG - 796-804 LID - S2405-4577(24)01278-6 [pii] LID - 10.1016/j.clnesp.2024.08.006 [doi] AB - BACKGROUND & AIMS: The double burden of malnutrition compels us to reconsider macronutrients from a diet quality perspective. The Macronutrient Quality Index (MQI) has been designed to reflect overall macronutrient quality and is based on three sub-indexes: the carbohydrate quality index (CQI), the healthy plate protein quality index (HPPQI) and the fat quality index (FQI). Nutritional adequacy is an essential aspect of diet quality that should be captured by reliable dietary indexes. METHODS: We analyzed the association between the Macronutrient Quality Index (MQI) and micronutrient adequacy. Participants were children aged 4 and 5 years, recruited in the SENDO cohort. Baseline information was collected through a self-administered online questionnaire, which included information on sociodemographic, dietary, and lifestyle variables. Dietary information was obtained using a 147-item validated semi-quantitative food frequency questionnaire. Participants were categorized into tertiles based on their MQI score. We evaluated the intake of 20 micronutrients and assessed the probability of micronutrient adequacy using the Estimated Average Requirement cut-off point. RESULTS: Children in the highest tertile of MQI had 0.33-fold lower odds (95%CI 0.17-0.66) of having >/=3 inadequate micronutrient intakes than their peers in the lowest tertile, after adjusting for potential confounders. The adjusted proportions of children with inadequate intake of >/=3 micronutrients were 18%, 14% and 11% in the first, second, and third tertiles of MQI respectively. The MQI appears to be capable of capturing nutrient adequacy in children, although our results suggest that a modified MQI, with eggs and dairy products weighted positively, might be more adequate for the pediatric population. CI - Copyright (c) 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Fabios, Elise AU - Fabios E AD - University of Navarra, Department of Preventive Medicine and Public Health, School of Medicine, Pamplona, Spain. FAU - Zazpe, Itziar AU - Zazpe I AD - University of Navarra, Department of Preventive Medicine and Public Health, School of Medicine, Pamplona, Spain; IdiSNA, Instituto de Investigacion Sanitaria de Navarra, Pamplona, Spain; Biomedical Research Centre Network on Obesity and Nutrition (CIBERobn), Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain; Department of Nutrition, Food Science and Physiology, School of Pharmacy, University of Navarra, Pamplona, Spain. FAU - Garcia-Blanco, Lorena AU - Garcia-Blanco L AD - IdiSNA, Instituto de Investigacion Sanitaria de Navarra, Pamplona, Spain; Olite Primary Care Health Center. Servicio Navarro de Salud-Osasunbidea, Pamplona, Spain. FAU - de la O, Victor AU - de la O V AD - University of Navarra, Department of Preventive Medicine and Public Health, School of Medicine, Pamplona, Spain; Precision Nutrition and Cardiometabolic Health Program, IMDEA Food, Spain. FAU - Martinez-Gonzalez, Miguel Angel AU - Martinez-Gonzalez MA AD - University of Navarra, Department of Preventive Medicine and Public Health, School of Medicine, Pamplona, Spain; IdiSNA, Instituto de Investigacion Sanitaria de Navarra, Pamplona, Spain; Biomedical Research Centre Network on Obesity and Nutrition (CIBERobn), Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain. FAU - Martin-Calvo, Nerea AU - Martin-Calvo N AD - University of Navarra, Department of Preventive Medicine and Public Health, School of Medicine, Pamplona, Spain; IdiSNA, Instituto de Investigacion Sanitaria de Navarra, Pamplona, Spain; Biomedical Research Centre Network on Obesity and Nutrition (CIBERobn), Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain. Electronic address: nmartincalvo@unav.es. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240821 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 RN - 0 (Micronutrients) RN - 0 (Nutrients) RN - 0 (Dietary Carbohydrates) RN - 0 (Dietary Proteins) RN - 0 (Dietary Fats) SB - IM MH - Humans MH - *Micronutrients/administration & dosage MH - Female MH - Male MH - Child, Preschool MH - *Nutrients MH - *Nutritional Status MH - Surveys and Questionnaires MH - Diet MH - Dietary Carbohydrates/administration & dosage MH - Dietary Proteins/administration & dosage MH - Nutrition Assessment MH - Dietary Fats/administration & dosage MH - Nutritional Requirements OTO - NOTNLM OT - Carbohydrates OT - Diet quality OT - Macronutrient quality index OT - Micronutrient intake adequacy OT - Proteins OT - SENDO cohort COIS- Declaration of competing interest The authors declare no conflict of interest. EDAT- 2024/08/23 00:43 MHDA- 2024/09/25 07:03 CRDT- 2024/08/22 19:21 PHST- 2024/01/16 00:00 [received] PHST- 2024/06/19 00:00 [revised] PHST- 2024/08/13 00:00 [accepted] PHST- 2024/09/25 07:03 [medline] PHST- 2024/08/23 00:43 [pubmed] PHST- 2024/08/22 19:21 [entrez] AID - S2405-4577(24)01278-6 [pii] AID - 10.1016/j.clnesp.2024.08.006 [doi] PST - ppublish SO - Clin Nutr ESPEN. 2024 Oct;63:796-804. doi: 10.1016/j.clnesp.2024.08.006. Epub 2024 Aug 21. PMID- 39173840 OWN - NLM STAT- MEDLINE DCOM- 20240909 LR - 20260526 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 202 DP - 2024 Nov 1 TI - Category-specific general Pavlovian-instrumental transfer. PG - 107640 LID - S0195-6663(24)00443-4 [pii] LID - 10.1016/j.appet.2024.107640 [doi] AB - Modern living is characterized by easy access to highly palatable energy-dense foods. Environmental cues associated with palatable foods increase seeking of those foods (specific transfer) and other palatable foods (general transfer). We conducted a series of studies testing the boundaries of food cue-reactivity by evaluating the impact of broader flavor associations (i.e. saltiness, sweetness) in eliciting general transfer effects. Experiment 1 was an online experiment with fictive rewards that tested if two actions associated with different food rewards (chip and chocolate points) could be provoked by images of other foods that were either similar or distinct in flavor from the foods associated with these instrumental actions. We observed that response excitation was only elicited by similarly flavored food cues, whereas distinctly flavored food cues inhibited response rates relative to control cues. Experiment 2 confirmed this observation in a classroom setting where real food rewards were contingent on task performance. Experiment 3 was an online study that further confirmed the reliability of the effects with a well powered sample. There were moderate-to-strong associations between specific and general transfer effects across all studies, suggesting overlapping cognitive processes are responsible for both transfer effects. These data improve the mechanistic understanding of how broad category associations can moderate the impact of food cues on food choices. This knowledge could be helpful for improving the precision of psychological interventions that seek to mitigate the impact of food cue-reactivity. CI - Crown Copyright (c) 2024. Published by Elsevier Ltd. All rights reserved. FAU - Mahlberg, Justin AU - Mahlberg J AD - School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Australia. Electronic address: justin.mahlberg@monash.edu. FAU - Weidemann, Gabrielle AU - Weidemann G AD - School of Psychology, Western Sydney University, Australia; MARCS Institute for Brain, Behaviour, and Development, Western Sydney University, Australia. LA - eng PT - Journal Article DEP - 20240820 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - *Cues MH - Female MH - Male MH - Young Adult MH - Adult MH - *Food Preferences/psychology MH - *Reward MH - *Transfer, Psychology MH - Taste MH - Adolescent MH - Conditioning, Classical MH - Choice Behavior MH - Conditioning, Operant COIS- Declaration of competing interest None. EDAT- 2024/08/23 00:43 MHDA- 2024/09/10 00:43 CRDT- 2024/08/22 19:20 PHST- 2024/05/03 00:00 [received] PHST- 2024/08/10 00:00 [revised] PHST- 2024/08/19 00:00 [accepted] PHST- 2024/09/10 00:43 [medline] PHST- 2024/08/23 00:43 [pubmed] PHST- 2024/08/22 19:20 [entrez] AID - S0195-6663(24)00443-4 [pii] AID - 10.1016/j.appet.2024.107640 [doi] PST - ppublish SO - Appetite. 2024 Nov 1;202:107640. doi: 10.1016/j.appet.2024.107640. Epub 2024 Aug 20. PMID- 39172553 OWN - NLM STAT- MEDLINE DCOM- 20250218 LR - 20250617 IS - 1945-7197 (Electronic) IS - 0021-972X (Print) IS - 0021-972X (Linking) VI - 110 IP - 3 DP - 2025 Feb 18 TI - A Mathematical Model-Derived Disposition Index Without Insulin Validated in Youth With Obesity. PG - 706-714 LID - 10.1210/clinem/dgae582 [doi] AB - CONTEXT: The gold-standard clamp measurements for insulin sensitivity (cSI), beta-cell function (cBCF), and disposition index (cDI = cSI x cBCF) are not practical in large-scale studies. OBJECTIVE: We sought to 1) validate a mathematical model-derived DI from oral glucose tolerance tests (OGTT) with insulin (mDI) and without (mDI-woI) against cDI and oral disposition index (oDI) and 2) evaluate the ability of the novel indices to detect prediabetes and type 2 diabetes (T2D). METHODS: We carried out a secondary analysis of previously reported cross-sectional observational studies. The Insulin Sensitivity and Secretion mathematical model for glucose-insulin dynamics was applied to 5-point and 3-point OGTTs synchronized with hyperinsulinemic-euglycemic and hyperglycemic clamps from 130 youth with obesity (68 normal glucose tolerance [NGT], 33 impaired glucose tolerance [IGT], 29 T2D). RESULTS: Model-derived DI correlated well with clamp DI (R = 0.76 [logged]). Between NGT and IGT, mDI and mDI-woI decreased more than oDI and cDI, (60% and 59% vs 29% and 27%), and by receiver operating characteristic analysis were superior at detecting IGT compared with oDI and cDI (area under the curve [AUC] 0.88-0.87 vs 0.68-0.65), as was mean glucose (AUC 0.87). CONCLUSION: mDI-woI is better than oDI or the labor-intensive cDI for detecting dysglycemia in obese youth. Bypassing insulin measurements with mDI-woI from the OGTT provides a cost-effective approach for large-scale epidemiological studies of dysglycemia in youth. CI - Published by Oxford University Press on behalf of the Endocrine Society 2024. FAU - Ha, Joon AU - Ha J AD - Department of Mathematics, Howard University, Washington, DC 20059, USA. FAU - Kim, Joon Young AU - Kim JY AD - Department of Exercise Science, David B. Falk College of Sport and Human Dynamics, Syracuse University, Syracuse, NY 13244, USA. FAU - Springer, Max AU - Springer M AUID- ORCID: 0000-0001-9291-6574 AD - Department of Mathematics, University of Maryland, College Park, MD 20742, USA. FAU - Chhabra, Aaryan AU - Chhabra A AD - Department of Biology, Indian Institute of Science Education and Research, Pune, Maharashtra 411008, India. FAU - Chung, Stephanie T AU - Chung ST AD - Section on Pediatric Diabetes, Obesity, and Metabolism, NIDDK, NIH, Bethesda, MD 20892, USA. FAU - Sumner, Anne E AU - Sumner AE AD - Intramural Research Program, National Institute on Minority Health and Health Disparities (NIMHD), National Institutes of Health, Bethesda, MD 20892, USA. AD - Section on Ethnicity and Health, Diabetes Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20892, USA. AD - Hypertension in Africa Research Team, North-West University, Potchefstroom, North-West 2520, South Africa. FAU - Sherman, Arthur S AU - Sherman AS AUID- ORCID: 0000-0002-8372-5941 AD - Laboratory of Biological Modeling, NIDDK, NIH, Bethesda, MD 20892, USA. FAU - Arslanian, Silva AU - Arslanian S AUID- ORCID: 0000-0002-1528-9324 AD - Center for Pediatric Research in Obesity and Metabolism, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA. AD - Division of Pediatric Endocrinology and Metabolism, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA. LA - eng GR - UL1 RR024153/RR/NCRR NIH HHS/United States GR - DGE 1840340)/National Science Foundation Graduate Research Fellowship Program/ GR - a dkNET New Investigator Pilot Program in Bioinformatics/ GR - A.C/ GR - NIH R01 HD27503/ GR - NIH UL1TR001857/ GR - Department of Science and Technology/ GR - NH/NIH HHS/United States GR - R01 HD027503/HD/NICHD NIH HHS/United States GR - UL1 TR001857/TR/NCATS NIH HHS/United States GR - NIH K24 HD/DK01357/ GR - 2022H1D3A2A01063552/National Research Foundation of Korea/ GR - RR024153/ PT - Journal Article PT - Observational Study PT - Validation Study PL - United States TA - J Clin Endocrinol Metab JT - The Journal of clinical endocrinology and metabolism JID - 0375362 RN - 0 (Insulin) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - Male MH - Female MH - Glucose Tolerance Test MH - Adolescent MH - Glucose Clamp Technique MH - *Insulin/blood/metabolism MH - *Prediabetic State/diagnosis/metabolism/blood MH - Cross-Sectional Studies MH - *Diabetes Mellitus, Type 2/diagnosis/metabolism/blood MH - *Insulin Resistance/physiology MH - Child MH - *Pediatric Obesity/metabolism/complications/blood MH - *Models, Theoretical MH - Blood Glucose/analysis/metabolism MH - Glucose Intolerance/diagnosis/metabolism/blood MH - *Obesity PMC - PMC11834730 OTO - NOTNLM OT - disposition index OT - hyperglycemic clamp OT - hyperinsulinemic euglycemic clamp OT - insulin resistance OT - oral glucose tolerance test OT - beta-cell function EDAT- 2024/08/22 18:42 MHDA- 2025/02/18 18:20 PMCR- 2024/08/22 CRDT- 2024/08/22 12:23 PHST- 2024/04/24 00:00 [received] PHST- 2025/02/18 18:20 [medline] PHST- 2024/08/22 18:42 [pubmed] PHST- 2024/08/22 12:23 [entrez] PHST- 2024/08/22 00:00 [pmc-release] AID - 7738986 [pii] AID - dgae582 [pii] AID - 10.1210/clinem/dgae582 [doi] PST - ppublish SO - J Clin Endocrinol Metab. 2025 Feb 18;110(3):706-714. doi: 10.1210/clinem/dgae582. PMID- 39171077 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240823 IS - 2666-6065 (Electronic) IS - 2666-6065 (Linking) VI - 49 DP - 2024 Aug TI - Establish a noninvasive model to screen metabolic dysfunction-associated steatotic liver disease in children aged 6-14 years in China and its applications in high-obesity-risk countries and regions. PG - 101150 LID - 10.1016/j.lanwpc.2024.101150 [doi] LID - 101150 AB - BACKGROUND: The prevalence of metabolic-associated steatotic liver disease (MASLD) is rising precipitously among children, particularly in regions or countries burdened with high prevalence of obesity. However, identifying those at high risk remains a significant challenge, as the majority do not exhibit distinct symptoms of MASLD. There is an urgent need for a widely accepted non-invasive predictor to facilitate early disease diagnosis and management of the disease. Our study aims to 1) evaluate and compare existing predictors of MASLD, and 2) develop a practical screening strategy for children, tailored to local prevalence of obesity. METHODS: We utilized a school-based cross-sectional survey in Beijing as the training dataset to establish predictive models for screening MASLD in children. An independent school-based study in Ningbo was used to validate the models. We selected the optimal non-invasive MASLD predictor by comparing logistic regression model, random forest model, decision tree model, and support vector machine model using both the Beijing and Ningbo datasets. This was followed by serial testing using the best performance index we identified and indices from previous studies. Finally, we calculated the potential MASLD screening recommendation categories and corresponding profits based on national and subnational obesity prevalence, and applied those three categories to 200 countries according to their obesity prevalence from 1990 to 2022. FINDINGS: A total of 1018 children were included (N(Beijing) = 596, N(Ningbo) = 422). The logistic regression model demonstrated the best performance, identifying the waist-to-height ratio (WHtR, cutoff value >/=0.48) as the optimal noninvasive index for predicting MASLD, with strong performance in both training and validation set. Additionally, the combination of WHtR and lipid accumulation product (LAP) was selected as an optimal serial test to improve the positive predictive value, with a LAP cutoff value of >/=668.22 cm x mg/dL. Based on the obesity prevalence among 30 provinces, three MASLD screening recommendations were proposed: 1) "Population-screening-recommended": For regions with an obesity prevalence >/=12.0%, where MASLD prevalence ranged from 5.0% to 21.5%; 2) "Resources-permitted": For regions with an obesity prevalence between 8.4% and 12.0%, where MASLD prevalence ranged from 2.3% to 4.4%; 3) "Population-screening-not-recommended": For regions with an obesity prevalence <8.4%, where MASLD prevalence is difficult to detect using our tool. Using our proposed cutoff for screening MASLD, the number of countries classified into the "Population-screening-recommended" and "Resources-permitted" categories increased from one and 11 in 1990 to 95 and 28 in 2022, respectively. INTERPRETATION: WHtR might serve as a practical and accessible index for predicting pediatric MASLD. A WHtR value >/=0.48 could facilitate early identification and management of MASLD in areas with obesity prevalence >/=12.0%. Furthermore, combining WHtR >/=0.48 with LAP >/=668.22 cm x mg/dL is recommended for individual MASLD screening. Moreover, linking these measures with population obesity prevalence not only helps estimate MASLD prevalence but also indicates potential screening profits in regions at varying levels of obesity risk. FUNDING: This study was supported by grants from Capital's Funds for Health Improvement and Research (Grant No. 2022-1G-4251), National Natural Science Foundation of China (Grant No. 82273654), Major Science and Technology Projects for Health of Zhejiang Province (Grant No. WKJ-ZJ-2216), Cyrus Tang Foundation for Young Scholar 2022 (2022-B126) and Sino-German Mobility Programme (M-0015). CI - (c) 2024 The Author(s). FAU - Liu, Yunfei AU - Liu Y AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing, China. FAU - Wang, Youxin AU - Wang Y AD - Department of Maternal and Child Health, School of Public Health, Peking University Health Science Center, Beijing, China. FAU - Xing, Yunfei AU - Xing Y AD - Department of Maternal and Child Health, School of Public Health, Peking University Health Science Center, Beijing, China. FAU - Wolters, Maike AU - Wolters M AD - Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. FAU - Shi, Di AU - Shi D AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing, China. FAU - Zhang, Pingping AU - Zhang P AD - Ningbo Center for Healthy Lifestyle Research, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang Province, China. FAU - Dang, Jiajia AU - Dang J AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing, China. FAU - Chen, Ziyue AU - Chen Z AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing, China. FAU - Cai, Shan AU - Cai S AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing, China. FAU - Wang, Yaqi AU - Wang Y AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing, China. FAU - Liu, Jieyu AU - Liu J AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing, China. FAU - Wang, Xinxin AU - Wang X AD - Linyi University, Linyi, Shandong Province, China. FAU - Zhou, Haoyu AU - Zhou H AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing, China. FAU - Xu, Miao AU - Xu M AD - Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang Province, China. FAU - Guo, Lipo AU - Guo L AD - Changping Health Education Center for Primary and Secondary Schools, Beijing, China. FAU - Li, Yuanyuan AU - Li Y AD - Changping Health Education Center for Primary and Secondary Schools, Beijing, China. FAU - Song, Jieyun AU - Song J AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing, China. FAU - Li, Jing AU - Li J AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing, China. FAU - Dong, Yanhui AU - Dong Y AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing, China. FAU - Cui, Yanchun AU - Cui Y AD - Beijing Children's Hospital, Capital Medical University, Beijing, China. FAU - Hu, Peijin AU - Hu P AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing, China. FAU - Hebestreit, Antje AU - Hebestreit A AD - Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. FAU - Wang, Hai-Jun AU - Wang HJ AD - Department of Maternal and Child Health, School of Public Health, Peking University Health Science Center, Beijing, China. FAU - Li, Li AU - Li L AD - Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang Province, China. FAU - Ma, Jun AU - Ma J AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing, China. FAU - Yeo, Yee Hui AU - Yeo YH AD - Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, USA. FAU - Wang, Hui AU - Wang H AD - Department of Maternal and Child Health, School of Public Health, Peking University Health Science Center, Beijing, China. FAU - Song, Yi AU - Song Y AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing, China. LA - eng PT - Journal Article DEP - 20240725 PL - England TA - Lancet Reg Health West Pac JT - The Lancet regional health. Western Pacific JID - 101774968 PMC - PMC11338159 OTO - NOTNLM OT - Metabolic dysfunction-associated steatotic liver disease OT - Pediatrics OT - Screening recommendation categories OT - Waist-to-height ratio COIS- We declare no competing interests. EDAT- 2024/08/22 06:42 MHDA- 2024/08/22 06:43 PMCR- 2024/07/25 CRDT- 2024/08/22 04:47 PHST- 2024/03/17 00:00 [received] PHST- 2024/06/27 00:00 [revised] PHST- 2024/07/08 00:00 [accepted] PHST- 2024/08/22 06:43 [medline] PHST- 2024/08/22 06:42 [pubmed] PHST- 2024/08/22 04:47 [entrez] PHST- 2024/07/25 00:00 [pmc-release] AID - S2666-6065(24)00144-5 [pii] AID - 101150 [pii] AID - 10.1016/j.lanwpc.2024.101150 [doi] PST - epublish SO - Lancet Reg Health West Pac. 2024 Jul 25;49:101150. doi: 10.1016/j.lanwpc.2024.101150. eCollection 2024 Aug. PMID- 39168929 OWN - NLM STAT- MEDLINE DCOM- 20241104 LR - 20251002 IS - 1573-7330 (Electronic) IS - 1058-0468 (Print) IS - 1058-0468 (Linking) VI - 41 IP - 10 DP - 2024 Oct TI - Constructing a predictive model for live birth following fresh embryo transfer in antagonist protocol for polycystic ovary syndrome. PG - 2709-2719 LID - 10.1007/s10815-024-03232-4 [doi] AB - OBJECTIVE: The present research aims to assess the factors that influence live birth outcomes following fresh embryo transfers using antagonist protocols in individuals diagnosed with polycystic ovary syndrome (PCOS). Furthermore, it seeks to develop a predictive nomogram model to facilitate clinical decision-making and provide personalized treatment strategies. METHODS: This retrospective cohort research analyzed the clinical data of 1242 individuals having PCOS who went through fresh embryo transfers employing antagonist protocols and in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) at Fujian Provincial Maternal and Child Health Hospital between January 2018 and December 2022. Individuals were assigned randomly to a modeling group (869 cases) and a validation group (373 cases) in a 7:3 ratio. The Boruta algorithm and multivariable logistic regression were utilized to identify independent risk factors linked to live births after transfer. A predictive nomogram was subsequently developed. The discriminatory power of the model and its accuracy were monitored by utilizing receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis. RESULTS: Multivariable logistic regression analysis identified several independent factors that influence live birth rates in fresh embryo transfer cycles for individuals having PCOS using antagonist protocols, including female age, body mass index (BMI), infertility duration, serum testosterone levels, progesterone levels at the time of human chorionic gonadotropin (hCG) injection, number of high-quality cleavage-stage embryos, type of embryo transferred, and the total number of embryos transferred. Based on these findings, a predictive nomogram was developed. The area under the ROC curve stood at 0.804 (95% confidence interval (CI), 0.775-0.833) for the modeling group and 0.807 (95% CI, 0.762-0.851) for the validation group. Calibration curves confirmed that the predictions of the nomogram closely matched the actual live birth outcomes. Decision curve analysis highlighted that the model provides significant net benefits for predicting live birth rates, with optimal performance across a probability range of 16.5 to 88.6%. CONCLUSION: Independent factors, including female age, infertility duration, BMI, serum testosterone levels, progesterone levels on the day of hCG injection, and the number and type of high-quality cleavage-stage embryos transferred are pivotal in influencing live birth outcomes in fresh embryo transfer cycles under antagonist protocols in individuals with PCOS undergoing IVF/ICSI treatments. The predictive nomogram developed from these factors offers substantial predictive accuracy and clinical utility, providing a reliable basis for clinical prognosis, targeted interventions, and the development of personalized treatment plans. CI - (c) 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Zhu, Suqin AU - Zhu S AD - Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, No. 18 Daoshan Road, Fuzhou City, 350001, Fujian Province, China. AD - Fujian Maternal-Fetal Clinical Medicine Research Center, Fuzhou, 350001, China. FAU - Chen, Xiaojing AU - Chen X AD - Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, No. 18 Daoshan Road, Fuzhou City, 350001, Fujian Province, China. FAU - Li, Rongshan AU - Li R AD - Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, No. 18 Daoshan Road, Fuzhou City, 350001, Fujian Province, China. FAU - Jiang, Wenwen AU - Jiang W AD - Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, No. 18 Daoshan Road, Fuzhou City, 350001, Fujian Province, China. FAU - Zheng, Beihong AU - Zheng B AUID- ORCID: 0000-0002-7475-2569 AD - Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, No. 18 Daoshan Road, Fuzhou City, 350001, Fujian Province, China. zhengbeihong2010@163.com. AD - Fujian Maternal-Fetal Clinical Medicine Research Center, Fuzhou, 350001, China. zhengbeihong2010@163.com. FAU - Sun, Yan AU - Sun Y AD - Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, No. 18 Daoshan Road, Fuzhou City, 350001, Fujian Province, China. sunyanteam@163.com. AD - Fujian Key Laboratory of Prenatal Diagnosis and Birth Defect, Fuzhou, 350001, China. sunyanteam@163.com. LA - eng GR - 2022ZQNZD010/the major Scientific Research Program for Young and Middle-aged Health Professionals of Fujian Province/ GR - 2022GGA035/Fujian Provincial Health Technology Project/ GR - 2023J011221/the Fujian Provincial Natural Science Foundation of China/ GR - 2023J011229/the Fujian Provincial Natural Science Foundation of China/ GR - 2021YZ034011/the Key Project on the Integration of Industry, Education and Research Collaborative Innovation of Fujian Province/ GR - 2021ZD01002/the Key Project on Science and Technology Program of Fujian Health Commission/ GR - 2021Y2012/the innovation Platform Project of Science and Technology, Fujian Province/ PT - Journal Article DEP - 20240821 PL - Netherlands TA - J Assist Reprod Genet JT - Journal of assisted reproduction and genetics JID - 9206495 RN - 0 (Chorionic Gonadotropin) SB - IM MH - Humans MH - Female MH - *Polycystic Ovary Syndrome/therapy MH - *Embryo Transfer/methods MH - Pregnancy MH - Adult MH - *Live Birth/epidemiology MH - *Fertilization in Vitro/methods MH - *Sperm Injections, Intracytoplasmic/methods MH - *Ovulation Induction/methods MH - Retrospective Studies MH - Infertility, Female/therapy MH - Pregnancy Rate MH - Nomograms MH - Birth Rate MH - Chorionic Gonadotropin/blood/administration & dosage PMC - PMC11534932 OTO - NOTNLM OT - In vitro fertilization OT - Live birth OT - Nomogram OT - Polycystic ovary syndrome OT - Predictive model COIS- The authors declare no competing interests. EDAT- 2024/08/22 00:42 MHDA- 2024/11/04 12:24 PMCR- 2025/10/01 CRDT- 2024/08/21 23:14 PHST- 2024/06/08 00:00 [received] PHST- 2024/08/13 00:00 [accepted] PHST- 2024/11/04 12:24 [medline] PHST- 2024/08/22 00:42 [pubmed] PHST- 2024/08/21 23:14 [entrez] PHST- 2025/10/01 00:00 [pmc-release] AID - 10.1007/s10815-024-03232-4 [pii] AID - 3232 [pii] AID - 10.1007/s10815-024-03232-4 [doi] PST - ppublish SO - J Assist Reprod Genet. 2024 Oct;41(10):2709-2719. doi: 10.1007/s10815-024-03232-4. Epub 2024 Aug 21. PMID- 39167177 OWN - NLM STAT- MEDLINE DCOM- 20241028 LR - 20241223 IS - 1436-6215 (Electronic) IS - 1436-6207 (Print) IS - 1436-6207 (Linking) VI - 63 IP - 8 DP - 2024 Dec TI - Associations of maternal lifestyle factors with inadequate pregnancy weight gain: findings from the baseline data of the LIMIT prospective cohort study. PG - 2911-2920 LID - 10.1007/s00394-024-03473-0 [doi] AB - BACKGROUND/OBJECTIVES: Gestational Weight Gain (GWG) impacts maternal and fetal health; deviations from optimal ranges pose health risks. Maternal lifestyle before and during pregnancy strongly influences GWG. This study explores factors linked to inadequate GWG, focusing on Mediterranean Diet (MD) adherence and specific food consumption. SUBJECTS/METHODS: 178 pregnant women were enrolled at Fondazione IRCCS Policlinico San Matteo (Pavia) during pre-hospital care before birth meeting inclusion/exclusion criteria. Sociodemographic data, pre-pregnancy BMI, GWG, MD adherence, physical activity (PA) levels, and smoking habits were retrospectively collected. Validated questionnaires adapted for the target group, assessed MD adherence and PA level. Participants were classified into adequate (AGWG) and inadequate GWG groups following IOM guidelines. RESULTS: Among 200 pregnant women (aged 30-36), 37.1% experienced low GWG and 24.1% excessive GWG. Our study revealed a significant association between inadequate GWG and educational level (P = 0.011); pre-pregnancy BMI (P = 0.005); MD adherence (P = 0.008), and daily average consumption of vegetables (P < 0.001). Our results also showed that a lower risk of EGWG vs. AGWG was associated with daily average consumption of vegetables (RRR = 0.279, P = 0.004), while a higher risk of EGWG vs. AGWG was associated with high daily meat product consumption (> 1.5 portions/day) (RRR = 7.83, P = 0.03). CONCLUSION: These findings emphasize the importance of promoting lifestyle changes before and during pregnancy to tackle the increasing incidence of inadequate GWG and improve the health outcomes of both mother and child. CI - (c) 2024. The Author(s). FAU - El Masri, Dana AU - El Masri D AD - Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, 27100, Italy. FAU - Alemayohu, Mulubirhan Assefa AU - Alemayohu MA AD - Biostatistics and Clinical Epidemiology Unit, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, 27100, Italy. AD - Department of Epidemiology, School of Public Health, Mekelle University, Mekelle, Ethiopia. FAU - Loperfido, Federica AU - Loperfido F AUID- ORCID: 0000-0003-4138-7793 AD - Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, 27100, Italy. Federica.loperfido@unipv.it. FAU - Bianco, Irene AU - Bianco I AD - Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, 27100, Italy. FAU - Ferrara, Chiara AU - Ferrara C AD - Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, 27100, Italy. FAU - Cerbo, Rosa Maria AU - Cerbo RM AD - Neonatal Unit and Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, 27100, Italy. FAU - Ghirardello, Stefano AU - Ghirardello S AD - Neonatal Unit and Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, 27100, Italy. FAU - Monti, Maria Cristina AU - Monti MC AD - Biostatistics and Clinical Epidemiology Unit, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, 27100, Italy. FAU - Maccarini, Beatrice AU - Maccarini B AD - Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, 27100, Italy. FAU - Sottotetti, Francesca AU - Sottotetti F AD - Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, 27100, Italy. FAU - Civardi, Elisa AU - Civardi E AD - Neonatal Unit and Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, 27100, Italy. FAU - Garofoli, Francesca AU - Garofoli F AD - Neonatal Unit and Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, 27100, Italy. FAU - Angelini, Micol AU - Angelini M AD - Neonatal Unit and Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, 27100, Italy. FAU - Cena, Hellas AU - Cena H AD - Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, 27100, Italy. AD - Clinical Nutrition Unit, Department of General Medicine, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, 27100, Italy. FAU - De Giuseppe, Rachele AU - De Giuseppe R AD - Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, 27100, Italy. LA - eng PT - Journal Article DEP - 20240821 PL - Germany TA - Eur J Nutr JT - European journal of nutrition JID - 100888704 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Gestational Weight Gain MH - Adult MH - *Life Style MH - Prospective Studies MH - *Diet, Mediterranean/statistics & numerical data MH - Exercise MH - Body Mass Index MH - Cohort Studies MH - Surveys and Questionnaires MH - Italy PMC - PMC11519082 OTO - NOTNLM OT - Gestational weight gain OT - Lifestyle factors OT - Mediterranean diet OT - Physical activity COIS- The authors declare there are no competing financial interests in the work described. EDAT- 2024/08/21 17:41 MHDA- 2024/10/28 18:23 PMCR- 2024/08/21 CRDT- 2024/08/21 11:13 PHST- 2024/02/13 00:00 [received] PHST- 2024/07/22 00:00 [accepted] PHST- 2024/10/28 18:23 [medline] PHST- 2024/08/21 17:41 [pubmed] PHST- 2024/08/21 11:13 [entrez] PHST- 2024/08/21 00:00 [pmc-release] AID - 10.1007/s00394-024-03473-0 [pii] AID - 3473 [pii] AID - 10.1007/s00394-024-03473-0 [doi] PST - ppublish SO - Eur J Nutr. 2024 Dec;63(8):2911-2920. doi: 10.1007/s00394-024-03473-0. Epub 2024 Aug 21. PMID- 39165553 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240822 IS - 2220-3206 (Print) IS - 2220-3206 (Electronic) IS - 2220-3206 (Linking) VI - 14 IP - 8 DP - 2024 Aug 19 TI - Dietary inflammatory index and its impact on severity and recurrence of Tourette syndrome in children. PG - 1208-1215 LID - 10.5498/wjp.v14.i8.1208 [doi] AB - BACKGROUND: Tourette syndrome (TS) is a neurodevelopmental disorder characterized by the presence of motor and vocal tics, typically beginning in childhood. Despite significant research efforts, the exact pathophysiology of TS remains incompletely understood. Recent studies suggest that inflammation may play a role in the severity and progression of TS, pointing to the potential influence of dietary and lifestyle factors on the condition. Currently, research on the specific connection between dietary inflammatory index (DII) and TS is still in its early stages, requiring additional clinical and epidemiological studies to validate the strength and specific mechanisms of this connection. AIM: To investigate the association between DII and the severity, recurrence, and inflammatory levels of TS in children. METHODS: A total of 207 children diagnosed with TS in the pediatric department of Qingdao Chengyang People's Hospital from January 2022 to January 2023 were selected. They were divided into stable and unstable groups based on follow-up conditions. Before enrollment, general information of the children [age, gender, body mass index (BMI), guardian's education level, DII score, medical history, family history, academic stress, electronic device usage, medication, and disease progression] was assessed, and serum inflammatory levels were measured during follow-up visits. DII scores and Yale Global Tic Severity Scale (YGTSS) scores were calculated. Furthermore, based on YGTSS scores, the children were classified into mild, moderate, and severe groups. The DII, interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-alpha) levels in each group were compared. RESULTS: Follow-up surveys were completed by 207 children and their guardians. Among them, 117 children were in the stable group, and 90 were in the recurrent group. We found no statistically significant differences in age, gender, comorbidities, BMI, and disease duration between the two groups (P > 0.05). However, academic stress, electronic device usage, medication, guardian's education level, and DII scores showed statistically significant differences between the groups (P < 0.05). Multifactorial regression analysis revealed that guardian's anxiety level, DII score, medication, academic stress, and family history were statistically significant factors (P < 0.05) affecting the recurrence of TS in children. Therefore, anxiety level, DII score, medication status, electronic device usage, and academic stress were identified as factors influencing the recurrence of TS in children. Among them, DII score, academic stress, and family history had odds ratios (OR) greater than 1, indicating risk factors, whereas medication status and guardian's education level had OR values less than 1, indicating protective factors. According to the YGTSS scores, children were categorized into mild, moderate, and severe groups. Comparative analysis of DII and inflammatory levels in children with different degrees of tic disorders revealed that the severe group had the highest DII and inflammatory levels, followed by the moderate group, and the mild group had the lowest levels. The trend of TS progression was consistent with the DII results. Receiver operating characteristic curves were plotted to predict disease progression in patients with TS via inflammatory markers. The areas under the curve for IL-6, CRP, and TNF-alpha were 0.894 (95%CI: 0.817-0.969), 0.793 (95%CI: 0.694-0.893), and 0.728 (95%CI: 0.614-0.843) respectively, with statistically significant differences (P < 0.05). According to the Youden index, the optimal cutoff values were IL-6 = 3.775 ng/L (sensitivity 68.1% and specificity 68.4%), CRP = 6.650 mg/L (sensitivity 60.6% and specificity 68.4%), and TNF-alpha = 0.666 (sensitivity 60.6% and specificity 71.1%). CONCLUSION: We found a certain correlation between DII and the severity, recurrence, and inflammatory levels of TS in children. Reasonable reduction in the intake of pro-inflammatory foods may be beneficial in reducing the risk of disease progression in children with TS. CI - (c)The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. FAU - Wu, Xiao-Ping AU - Wu XP AD - Department of Pediatrics, Qingdao Chengyang People's Hospital, Qingdao 266109, Shandong Province, China. wuxiaoping111111@163.com. FAU - Fang, Rong-Rong AU - Fang RR AD - Department of Pediatrics, Qingdao Chengyang People's Hospital, Qingdao 266109, Shandong Province, China. FAU - Ji, Ting-Ting AU - Ji TT AD - Department of Pediatrics, Qingdao Chengyang People's Hospital, Qingdao 266109, Shandong Province, China. LA - eng PT - Journal Article DEP - 20240819 PL - United States TA - World J Psychiatry JT - World journal of psychiatry JID - 101610480 PMC - PMC11331388 OTO - NOTNLM OT - Correlation analysis OT - Dietary inflammation index OT - Impact on severity and recurrence OT - Inflammation levels OT - Pro-inflammatory foods OT - Tourette's syndrome COIS- Conflict-of-interest statement: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2024/08/21 11:41 MHDA- 2024/08/21 11:42 PMCR- 2024/08/19 CRDT- 2024/08/21 04:18 PHST- 2024/05/21 00:00 [received] PHST- 2024/07/03 00:00 [revised] PHST- 2024/07/11 00:00 [accepted] PHST- 2024/08/21 11:42 [medline] PHST- 2024/08/21 11:41 [pubmed] PHST- 2024/08/21 04:18 [entrez] PHST- 2024/08/19 00:00 [pmc-release] AID - 10.5498/wjp.v14.i8.1208 [doi] PST - epublish SO - World J Psychiatry. 2024 Aug 19;14(8):1208-1215. doi: 10.5498/wjp.v14.i8.1208. eCollection 2024 Aug 19. PMID- 39164717 OWN - NLM STAT- MEDLINE DCOM- 20240821 LR - 20250131 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 Aug 20 TI - Awareness and knowledge of cardiovascular disease and their associations with the lifestyles of 8-16-year-old girls: a perspective from Saudi Arabia. PG - 2256 LID - 10.1186/s12889-024-19698-x [doi] LID - 2256 AB - BACKGROUND: There has been an increased focus on children as a target for primordial prevention of cardiovascular disease (CVD). In particular, girls should receive attention to combat the burden of CVD in women, because women have higher CVD mortality and morbidity rates than men do. As health literacy is paramount, the evaluation of awareness, and knowledge of CVD and its risk factors and their associations with the lifestyles of girls forms the basis for planning cardiovascular health promotion programs aiming to improve girls' immediate health and reduce the future burden of CVD among women. METHODS: A prospective cross-sectional study was conducted on a random sample of girls attending elementary and intermediate schools in Riyadh, Saudi Arabia. The girls completed a newly validated 24-item questionnaire that assessed their demographic data, lifestyles, and awareness and knowledge of CVD and its risk factors. Anthropometric and blood pressure measurements were obtained. Knowledge scores were calculated on the basis of correct responses and compared between subgroups via analysis of variance to determine associated factors. RESULTS: In total, 469 girls (mean age of 12.5 years) were included. Approximately 41.4% of them did not exercise or only exercised once a week. The dietary intake of important food groups was below or just at the minimal recommended servings for most. Overall, 44.1% were overweight/obese, and almost half were identified as hypertensive on the basis of a single resting measurement. Awareness of CVD as a dangerous disease in adults was 50.3%, whereas, cancer was identified by 61% of participants. Individual risk factors were identified by approximately 25%, and 16.6% were not aware of any risk factors. The overall knowledge score of the participants was 2.6 (+/- 1.6) out of a total possible score of 8 representing 32.5% (+/- 20%). Knowledge levels were positively influenced by increasing school grade (P = 0.001) and family history of CVD (P < 0.001). There was no significant favorable association between improved knowledge level and lifestyle factors. CONCLUSION: The awareness and knowledge of CVD among girls aged 8-16 years are poor and are largely dissociated from their lifestyle. Improved knowledge scores with increasing school grade and family history of CVD confirm a role for schools and families in improving girls' knowledge. Our findings mirror those obtained in older women, showing that misinformation among women starts in childhood and should be targeted early in life. CI - (c) 2024. The Author(s). FAU - Al-Mohaissen, Maha A AU - Al-Mohaissen MA AD - Department of Clinical Sciences (Cardiology), College of Medicine, Princess Nourah bint Abdulrahman University, PO Box 84428, Riyadh, 11671, Saudi Arabia. maalmohaissen@pnu.edu.sa. FAU - Alohali, Sarah AU - Alohali S AD - Department of Pediatrics, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. FAU - Alhariqi, Ameera AU - Alhariqi A AD - Department of Pediatrics, King Abdullah bin Abdulaziz University Hospital, Riyadh, Saudi Arabia. FAU - Alotaibi, Ahad AU - Alotaibi A AD - Department of General Surgery, King Abdulaziz Medical City, Riyadh, Saudi Arabia. FAU - Almedbal, Haifa AU - Almedbal H AD - Department of General Surgery, King Saud Medical City, Riyadh, Saudi Arabia. FAU - AlMehisen, Rabah AU - AlMehisen R AD - Department of Adult Cardiology, Prince Sultan Cardiac Center, Riyadh, Saudi Arabia. FAU - Almasri, Badriah AU - Almasri B AD - General Administration of Education in Riyadh Region, Ministry of Education, Riyadh, Saudi Arabia. FAU - Lee, Terry AU - Lee T AD - Centre for Advancing Health Outcomes, St. Paul's Hospital, Vancouver, BC, Canada. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240820 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Female MH - *Cardiovascular Diseases/prevention & control/epidemiology MH - *Health Knowledge, Attitudes, Practice MH - Adolescent MH - Cross-Sectional Studies MH - Child MH - Prospective Studies MH - *Life Style MH - Surveys and Questionnaires MH - Risk Factors PMC - PMC11334403 OTO - NOTNLM OT - Awareness, knowledge OT - Cardiovascular disease OT - Cardiovascular disease in women OT - Children OT - Girls OT - Risk factors COIS- The authors declare no competing interests. EDAT- 2024/08/21 03:50 MHDA- 2024/08/21 11:41 PMCR- 2024/08/20 CRDT- 2024/08/20 23:42 PHST- 2023/12/10 00:00 [received] PHST- 2024/08/06 00:00 [accepted] PHST- 2024/08/21 11:41 [medline] PHST- 2024/08/21 03:50 [pubmed] PHST- 2024/08/20 23:42 [entrez] PHST- 2024/08/20 00:00 [pmc-release] AID - 10.1186/s12889-024-19698-x [pii] AID - 19698 [pii] AID - 10.1186/s12889-024-19698-x [doi] PST - epublish SO - BMC Public Health. 2024 Aug 20;24(1):2256. doi: 10.1186/s12889-024-19698-x. PMID- 39163911 OWN - NLM STAT- MEDLINE DCOM- 20240915 LR - 20261019 IS - 1090-2139 (Electronic) IS - 0889-1591 (Linking) VI - 122 DP - 2024 Nov TI - Socioeconomic adversity, maternal nutrition, and the prenatal programming of offspring cognition and language at two years of age through maternal inflammation. PG - 471-482 LID - S0889-1591(24)00556-7 [pii] LID - 10.1016/j.bbi.2024.08.033 [doi] AB - Increasing rates of child neurodevelopmental vulnerability are a significant public health challenge. The adverse effect of socioeconomic adversity on offspring cognition may be mediated through elevated prenatal maternal systemic inflammation, but the role of modifiable antecedents such as maternal nutrition has not yet been clarified. This study aimed to examine (1) whether prenatal factors, with an emphasis on maternal nutrition, were associated with prenatal maternal systemic inflammation at 28 weeks' gestation, including the metabolomic marker glycoprotein acetyls (GlycA); (2) the extent to which the association between prenatal maternal nutrition and child cognition and language at age two years was mediated by elevated maternal inflammation in pregnancy; (3) the extent to which the associations between prenatal socioeconomic adversity and child neurodevelopment were mediated through prenatal maternal nutrition and GlycA levels. We used a prospective population-derived pre-birth longitudinal cohort study, the Barwon Infant Study (Barwon region of Victoria, Australia), where 1074 mother-child pairs were recruited by 28 weeks' gestation using an unselected sampling frame. Exposures included prenatal factors such as maternal diet measured by a validated food frequency questionnaire at 28 weeks' gestation and dietary patterns determined by principal component analysis. The main outcome measures were maternal inflammatory biomarkers (GlycA and hsCRP levels) at 28 weeks' gestation, and offspring Bayley-III cognition and language scores at age two years. Results showed that the 'modern wholefoods' and 'processed' maternal dietary patterns were independently associated with reduced and elevated maternal inflammation respectively (GlycA or hsCRP p < 0.001), and also with higher and reduced offspring Bayley-III scores respectively (cognition p 20 years in a longitudinal cohort. At age 26-35 years, participants reported childhood maltreatment (physical, sexual, and emotional abuse; emotional neglect) and, 5 years later, about prepregnancy weight and gestational weight gain for previous pregnancies (n = 656). Modified Poisson regression models were used to estimate associations of maltreatment history with prepregnancy BMI and gestational weight gain z -scores, adjusting for sociodemographics. We used multivariate imputation by chained equations to adjust outcome measures for misclassification using data from an internal validation study. RESULTS: Before misclassification adjustment, results indicated a higher risk of prepregnancy BMI >/=30 kg/m 2 in women with certain types of maltreatment (e.g., emotional abuse risk ratio = 2.4; 95% confidence interval: 1.5, 3.7) compared with women without that maltreatment type. After misclassification adjustment, estimates were attenuated but still modestly elevated (e.g., emotional abuse risk ratio = 1.7; 95% confidence interval: 1.1, 2.7). Misclassification-adjusted estimates for maltreatment associations with gestational weight gain z -scores were close to the null and imprecise. CONCLUSIONS: Findings suggest an association of maltreatment with prepregnancy BMI >/=30 kg/m 2 but not with high gestational weight gain. Results suggest a potential need for equitable interventions that can support all women, including those with maltreatment histories, as they enter pregnancy. CI - Copyright (c) 2024 Wolters Kluwer Health, Inc. All rights reserved. FAU - Mason, Susan M AU - Mason SM AUID- ORCID: 0000-0002-7635-9832 AD - From the Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN. FAU - Farkas, Kriszta AU - Farkas K AD - From the Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN. FAU - Bodnar, Lisa M AU - Bodnar LM AD - Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, PA. FAU - Friedman, Jessica K AU - Friedman JK AD - Center for Care Delivery and Outcomes Research, Minneapolis Veterans Administration Health Care System, Minneapolis, MN. FAU - Johnson, Sydney T AU - Johnson ST AD - From the Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN. FAU - Emery Tavernier, Rebecca L AU - Emery Tavernier RL AD - Weitzman Institute, Moses Weitzman Health System, Middletown, CT. AD - Department of Family and Biobehavioral Health, University of Minnesota Medical School, Duluth campus, Duluth, MN. FAU - MacLehose, Richard F AU - MacLehose RF AD - From the Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN. FAU - Neumark-Sztainer, Dianne AU - Neumark-Sztainer D AD - From the Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN. LA - eng GR - P2C HD041023/HD/NICHD NIH HHS/United States GR - R01 HD090053/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20240819 PL - United States TA - Epidemiology JT - Epidemiology (Cambridge, Mass.) JID - 9009644 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Adult MH - *Body Mass Index MH - *Gestational Weight Gain MH - Longitudinal Studies MH - Adult Survivors of Child Abuse/statistics & numerical data MH - Pregnancy Outcome/epidemiology MH - Obesity/epidemiology MH - Child Abuse/statistics & numerical data/psychology PMC - PMC11560690 MID - NIHMS2016525 COIS- Disclosure: The authors report no conflicts of interest. EDAT- 2024/08/19 18:42 MHDA- 2024/11/13 13:48 PMCR- 2025/11/01 CRDT- 2024/08/19 12:02 PHST- 2024/11/13 13:48 [medline] PHST- 2024/08/19 18:42 [pubmed] PHST- 2024/08/19 12:02 [entrez] PHST- 2025/11/01 00:00 [pmc-release] AID - 00001648-202411000-00017 [pii] AID - 10.1097/EDE.0000000000001788 [doi] PST - ppublish SO - Epidemiology. 2024 Nov 1;35(6):885-894. doi: 10.1097/EDE.0000000000001788. Epub 2024 Aug 19. PMID- 39158907 OWN - NLM STAT- MEDLINE DCOM- 20240819 LR - 20250304 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 7 IP - 8 DP - 2024 Aug 1 TI - Machine Learning Prediction of Autism Spectrum Disorder From a Minimal Set of Medical and Background Information. PG - e2429229 LID - 10.1001/jamanetworkopen.2024.29229 [doi] LID - e2429229 AB - IMPORTANCE: Early identification of the likelihood of autism spectrum disorder (ASD) using minimal information is crucial for early diagnosis and intervention, which can affect developmental outcomes. OBJECTIVE: To develop and validate a machine learning (ML) model for predicting ASD using a minimal set of features from background and medical information and to evaluate the predictors and the utility of the ML model. DESIGN, SETTING, AND PARTICIPANTS: For this diagnostic study, a retrospective analysis of the Simons Foundation Powering Autism Research for Knowledge (SPARK) database, version 8 (released June 6, 2022), was conducted, including data from 30 660 participants after adjustments for missing values and class imbalances (15 330 with ASD and 15 330 without ASD). The SPARK database contains participants recruited from 31 university-affiliated research clinicals and online in 26 states in the US. All individuals with a professional ASD diagnosis and their families were eligible to participate. The model performance was validated on independent datasets from SPARK, version 10 (released July 21, 2023), and the Simons Simplex Collection (SSC), consisting of 14 790 participants, followed by phenotypic associations. EXPOSURES: Twenty-eight basic medical screening and background history items present before 24 months of age. MAIN OUTCOMES AND MEASURES: Generalizable ML prediction models were developed for detecting ASD using 4 algorithms (logistic regression, decision tree, random forest, and eXtreme Gradient Boosting [XGBoost]). Performance metrics included accuracy, area under the receiver operating characteristics curve (AUROC), sensitivity, specificity, positive predictive value (PPV), and F1 score, offering a comprehensive assessment of the predictive accuracy of the model. Explainable AI methods were applied to determine the effect of individual features in predicting ASD as secondary outcomes, enhancing the interpretability of the best-performing model. The secondary outcome analyses were further complemented by examining differences in various phenotypic measures using nonparametric statistical methods, providing insights into the ability of the model to differentiate between different presentations of ASD. RESULTS: The study included 19 477 (63.5%) male and 11 183 (36.5%) female participants (mean [SD] age, 106 [62] months). The mean (SD) age was 113 (68) months for the ASD group and 100 (55) months for the non-ASD group. The XGBoost (termed AutMedAI) model demonstrated strong performance with an AUROC score of 0.895, sensitivity of 0.805, specificity of 0.829, and PPV of 0.897. Developmental milestones and eating behavior were the most important predictors. Validation on independent cohorts showed an AUROC of 0.790, indicating good generalizability. CONCLUSIONS AND RELEVANCE: In this diagnostic study of ML prediction of ASD, robust model performance was observed to identify autistic individuals with more symptoms and lower cognitive levels. The robustness and ML model generalizability results are promising for further validation and use in clinical and population settings. FAU - Rajagopalan, Shyam Sundar AU - Rajagopalan SS AD - Center of Neurodevelopmental Disorders, Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden. AD - Department of Highly Specialized Pediatric Orthopedics and Medicine, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Region Stockholm, Stockholm, Sweden. AD - Institute of Bioinformatics and Applied Biotechnology, Bengaluru, India. FAU - Zhang, Yali AU - Zhang Y AD - Center of Neurodevelopmental Disorders, Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden. AD - Department of Highly Specialized Pediatric Orthopedics and Medicine, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Region Stockholm, Stockholm, Sweden. FAU - Yahia, Ashraf AU - Yahia A AD - Center of Neurodevelopmental Disorders, Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden. AD - Department of Highly Specialized Pediatric Orthopedics and Medicine, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Region Stockholm, Stockholm, Sweden. FAU - Tammimies, Kristiina AU - Tammimies K AD - Center of Neurodevelopmental Disorders, Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden. AD - Department of Highly Specialized Pediatric Orthopedics and Medicine, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Region Stockholm, Stockholm, Sweden. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240801 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Humans MH - *Machine Learning MH - *Autism Spectrum Disorder/diagnosis MH - Female MH - Male MH - Retrospective Studies MH - Child MH - Child, Preschool PMC - PMC11333987 COIS- Conflict of Interest Disclosures: Dr Tammimies reported receiving grant funding from the Swedish Research Council and FORTE outside the submitted work, personal fees from npj Genomic Medicine and the International Journal of Developmental Neuroscience for working as an associate editor, and personal fees from the European Research Council for reviewing outside the submitted work. No other disclosures were reported. EDAT- 2024/08/19 12:42 MHDA- 2024/08/19 12:43 PMCR- 2024/08/19 CRDT- 2024/08/19 11:34 PHST- 2024/08/19 12:43 [medline] PHST- 2024/08/19 12:42 [pubmed] PHST- 2024/08/19 11:34 [entrez] PHST- 2024/08/19 00:00 [pmc-release] AID - 2822394 [pii] AID - zoi240885 [pii] AID - 10.1001/jamanetworkopen.2024.29229 [doi] PST - epublish SO - JAMA Netw Open. 2024 Aug 1;7(8):e2429229. doi: 10.1001/jamanetworkopen.2024.29229. PMID- 39155363 OWN - NLM STAT- MEDLINE DCOM- 20240818 LR - 20240821 IS - 2047-783X (Electronic) IS - 0949-2321 (Print) IS - 0949-2321 (Linking) VI - 29 IP - 1 DP - 2024 Aug 19 TI - Concurrent validity between self-reported International Physical Activity Questionnaire Short Form and Fibion accelerometer data among young adults in the UAE. PG - 426 LID - 10.1186/s40001-024-01975-5 [doi] LID - 426 AB - Self-reported physical activity questionnaires (e.g., International Physical Activity Questionnaire, IPAQ) are a cost-effective, time-saving, and accessible method to assess sedentary behaviour and physical activity. There are conflicting findings regarding the validity of self-reported questionnaires in comparison to accelerometer-measured data in a free-living environment. This study aimed to investigate the concurrent validity between self-reported Arabic-English IPAQ short form (IPAQ-SF) and Fibion (Fibion Inc., Jyvaskyla, Finland) accelerometer-measured sedentary and physical activity time among young adults. One hundred and one young healthy adults (mean age 20.8 +/- 2.4 years) filled in the IPAQ short form (IPAQ-SF) and wore the Fibion device on the anterior thigh for >/= 600 min per day for 4-7 days. Concurrent validity between the IPAQ-SF and Fibion accelerometer for sitting, walking, moderate activity, and vigorous activity time was assessed using the Spearman correlation coefficient ( rho ) and Bland-Altman plots. Significant weak associations between IPAQ-SF and Fibion measurements were found for total activity time ( rho = 0.4; P < 0.001) and for the duration of walking ( rho = 0.3; P = 0.01), moderate ( rho = 0.2; P = 0.02), and vigorous-intensity activities ( rho = 0.4; P < 0.001). However, rho was not significant ( rho = - 0.2; P = 0.09) for sitting time. In addition, all the plots of the measured variables showed a proportional bias. A low association and agreement were found between self-reported IPAQ-SF scores and Fibion accelerometer measurements among young adults in the UAE. Adult sedentary and physical activity measurements should be obtained objectively with accelerometers rather than being limited to self-reported measures. CI - (c) 2024. The Author(s). FAU - Arumugam, Ashokan AU - Arumugam A AD - Department of Physiotherapy, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. AD - Neuromusculoskeletal Rehabilitation Research Group, RIMHS-Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. AD - Sustainable Engineering Asset Management Research Group, RISE-Research Institute of Science and Engineering, University of Sharjah, Sharjah, United Arab Emirates. AD - Adjunct Faculty, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, India. FAU - Alsaafin, Nour AU - Alsaafin N AD - Department of Physiotherapy, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. AD - Neuromusculoskeletal Rehabilitation Research Group, RIMHS-Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. FAU - Shalash, Reime Jamal AU - Shalash RJ AD - Department of Physiotherapy, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. AD - Neuromusculoskeletal Rehabilitation Research Group, RIMHS-Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. FAU - Qadah, Raneen Mohammed AU - Qadah RM AD - Department of Physiotherapy, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. AD - Neuromusculoskeletal Rehabilitation Research Group, RIMHS-Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. FAU - Al-Sharman, Alham AU - Al-Sharman A AD - Department of Physiotherapy, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. AD - Neuromusculoskeletal Rehabilitation Research Group, RIMHS-Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. AD - Department of Rehabilitation Sciences, Faculty of Applied Medical Sciences , Jordan University of Science and Technology, Irbid, Jordan. FAU - Moustafa, Ibrahim M AU - Moustafa IM AD - Department of Physiotherapy, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. AD - Neuromusculoskeletal Rehabilitation Research Group, RIMHS-Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. AD - Faculty of Physical Therapy, Cairo University, Cairo, Egypt. FAU - Shousha, Tamer M AU - Shousha TM AD - Department of Physiotherapy, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. AD - Neuromusculoskeletal Rehabilitation Research Group, RIMHS-Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. AD - Faculty of Physical Therapy, Cairo University, Cairo, Egypt. FAU - Kumaran, Senthil D AU - Kumaran SD AD - Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, India. FAU - Migliorini, Filippo AU - Migliorini F AUID- ORCID: 0000-0001-7220-1221 AD - Department of Orthopaedic, Trauma, and Reconstructive Surgery, RWTH University Medical Centre, Pauwelsstrasse 30, 52074, Aachen, Germany. migliorini.md@gmail.com. AD - Department of Orthopedics and Trauma Surgery, Academic Hospital of Bolzano (SABES-ASDAA), 39100, Bolzano, Italy. migliorini.md@gmail.com. AD - Department of Life Sciences, Health, and Health Professions, Link Campus University, Rome, Italy. migliorini.md@gmail.com. FAU - Maffulli, Nicola AU - Maffulli N AD - Department of Trauma and Orthopaedic Surgery, Faculty of Medicine and Psychology, University La Sapienza, Rome, Italy. n.maffulli@qmul.ac.uk. AD - School of Pharmacy and Bioengineering, Keele University Faculty of Medicine, Stoke On Trent, England. n.maffulli@qmul.ac.uk. AD - Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Centre for Sports and Exercise Medicine,, Mile End Hospital, 275 Bancroft Road, London, E1 4DG, England. n.maffulli@qmul.ac.uk. LA - eng PT - Journal Article DEP - 20240819 PL - England TA - Eur J Med Res JT - European journal of medical research JID - 9517857 SB - IM MH - Humans MH - Male MH - Female MH - *Self Report MH - *Exercise/physiology MH - *Accelerometry/methods/instrumentation MH - Young Adult MH - Surveys and Questionnaires MH - Adult MH - United Arab Emirates MH - Sedentary Behavior MH - Reproducibility of Results MH - Adolescent PMC - PMC11331689 OTO - NOTNLM OT - Accelerometer OT - International Physical Activity Questionnaire (IPAQ-SF) OT - Physical activity OT - Validation COIS- The authors declare no competing interests. EDAT- 2024/08/19 00:42 MHDA- 2024/08/19 00:43 PMCR- 2024/08/19 CRDT- 2024/08/18 23:12 PHST- 2023/10/05 00:00 [received] PHST- 2024/07/14 00:00 [accepted] PHST- 2024/08/19 00:43 [medline] PHST- 2024/08/19 00:42 [pubmed] PHST- 2024/08/18 23:12 [entrez] PHST- 2024/08/19 00:00 [pmc-release] AID - 10.1186/s40001-024-01975-5 [pii] AID - 1975 [pii] AID - 10.1186/s40001-024-01975-5 [doi] PST - epublish SO - Eur J Med Res. 2024 Aug 19;29(1):426. doi: 10.1186/s40001-024-01975-5. PMID- 39153770 OWN - NLM STAT- MEDLINE DCOM- 20240817 LR - 20250205 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 14 IP - 8 DP - 2024 Aug 17 TI - Diagnostic performance of an albuminuria point-of-care test in screening for chronic kidney disease among young people living with HIV in Uganda: a cross-sectional study. PG - e083221 LID - 10.1136/bmjopen-2023-083221 [doi] LID - e083221 AB - OBJECTIVES: The main aim was to determine the diagnostic performance of an albuminuria point-of-care test (POC) for diagnosis of chronic kidney disease among young people living with HIV (YPLHIV) in Uganda. DESIGN: We conducted a cross-sectional study comparing the diagnostic performance of MicroalbuPHAN (Erba Lachema, Czech Republic), an albuminuria POC test against the laboratory-measured albumin and creatinine as the reference standard. SETTING: The study was set in seven HIV clinics in Kampala, Uganda that provide antiretroviral therapy to adults and children living with HIV. The study took place from April to August 2023. PARTICIPANTS: 497 YPLHIV aged 10-24 years who were diagnosed with HIV before 10 years of age were randomly selected from the HIV clinics. Pregnant YPLHIV were excluded. PROCEDURES: Participants provided a spot urine sample that was tested for albumin and creatinine using the POC and in the laboratory and proteinuria using urine dipstick. The sensitivity, specificity, negative and positive predictive values (NPV, PPV) of the POC versus the laboratory test were calculated, and factors associated with having a positive POC test were estimated using logistic regression. OUTCOME MEASURES: The primary outcome was a diagnosis of albuminuria defined as an albumin creatinine ratio above 30 mg/g. RESULTS: Of the 497 participants enrolled, 278 (55.9%) were female and 331 (66.8%) were aged 10-17 years. The POC test had a sensitivity of 74.5% (95% CI 70.6% to 78.4%) and specificity of 68.1% (95% CI 63.9% to 72.3%). The PPV was 21.5% (95% CI 17.8% to 25.1%) and the NPV was 95.8% (95% CI 94.0% to 97.6%), with an accuracy of 68.8%. There was strong evidence that a positive POC test was associated with having proteinuria (OR 2.82; 95% CI 1.89 to 4.22, p<0.001); body mass index <19.5 (OR 1.69 95% CI 1.17 to 2.45, p=0.005) and being male (OR 1.48; 95% CI 1.02 to 2.14, p=0.04). CONCLUSIONS: The albuminuria POC test had low sensitivity and specificity. However, it can be used to exclude kidney disease given its high NPV. It should be validated against the 24-hour urinary excretion rate to further determine its diagnostic performance. CI - (c) Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Nasuuna, Esther M AU - Nasuuna EM AUID- ORCID: 0000-0003-2923-6482 AD - Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda enasuuna@gmail.com. AD - Non-communicable Diseases Program, Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda. AD - Department of Infectious Disease Epidemiology and International Health, London School of Hygiene and Tropical Medicine, London, UK. FAU - Kalyesubula, Robert AU - Kalyesubula R AD - Non-communicable Diseases Program, Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda. AD - Departments of Physiology and Medicine, Makerere University College of Health Sciences, Kampala, Uganda. FAU - Tomlinson, Laurie A AU - Tomlinson LA AUID- ORCID: 0000-0001-8848-9493 AD - Department of non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK. FAU - Castelnuovo, Barbara AU - Castelnuovo B AUID- ORCID: 0000-0001-7756-5032 AD - Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda. FAU - Okello, Emmy AU - Okello E AD - Uganda Heart Institute Limited, Kampala, Uganda. AD - Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda. FAU - Dziva Chikwari, Chido AU - Dziva Chikwari C AUID- ORCID: 0000-0003-1617-3603 AD - Department of Infectious Disease Epidemiology and International Health, London School of Hygiene and Tropical Medicine, London, UK. AD - Biomedical Research and Training Institute, Harare, Zimbabwe. AD - MRC International Statistics and Epidemiology Group, London School of Hygiene & Tropical Medicine, London, UK. FAU - Weiss, Helen A AU - Weiss HA AUID- ORCID: 0000-0003-3547-7936 AD - MRC International Statistics and Epidemiology Group, London School of Hygiene & Tropical Medicine, London, UK. LA - eng GR - D43 TW009771/TW/FIC NIH HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240817 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 RN - AYI8EX34EU (Creatinine) SB - IM MH - Humans MH - Adolescent MH - Female MH - Uganda MH - Cross-Sectional Studies MH - *Albuminuria/diagnosis/urine MH - Male MH - *Renal Insufficiency, Chronic/diagnosis/urine MH - Young Adult MH - Child MH - *Point-of-Care Testing MH - *HIV Infections/complications/diagnosis MH - Creatinine/urine MH - Sensitivity and Specificity MH - Predictive Value of Tests PMC - PMC11331864 OTO - NOTNLM OT - Adolescent OT - HIV & AIDS OT - Nephrology OT - point of care COIS- Competing interests: None declared. EDAT- 2024/08/18 04:43 MHDA- 2024/08/18 04:44 PMCR- 2024/08/14 CRDT- 2024/08/17 20:52 PHST- 2024/08/18 04:44 [medline] PHST- 2024/08/18 04:43 [pubmed] PHST- 2024/08/17 20:52 [entrez] PHST- 2024/08/14 00:00 [pmc-release] AID - bmjopen-2023-083221 [pii] AID - 10.1136/bmjopen-2023-083221 [doi] PST - epublish SO - BMJ Open. 2024 Aug 17;14(8):e083221. doi: 10.1136/bmjopen-2023-083221. PMID- 39153666 OWN - NLM STAT- MEDLINE DCOM- 20240909 LR - 20260529 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 202 DP - 2024 Nov 1 TI - Psychometric properties of the toddler feeding style questionnaire in fathers and its gender invariance. PG - 107635 LID - S0195-6663(24)00438-0 [pii] LID - 10.1016/j.appet.2024.107635 [doi] AB - Parental feeding practices and behaviours are closely related to a number of child outcomes, including eating behaviour and health. The Toddler Feeding Style Questionnaire (TFSQ) was developed to provide an accurate instrument for evaluating parental feeding practices for toddlers by assessing two dimensions: responsiveness and demandingness. As the initial validation study was conducted in a sample of mothers only, the aims of this study are: a) to validate the TFSQ in fathers, b) to analyse its measurement invariance as a function of gender and parenting experience and c) to explore associations between socio-demographic variables and both dimensions. The TFSQ was completed by 377 fathers and 583 mothers. CFA confirmed the two-factor structure within the same items as the initial validation study, with good model fit indices (X(2) = 230.089; TLI = 0.883; CFI = 0.91; RMSEA = 0.08 (90% CI 0.068-0.092), SRMR = 0.070). Strict invariance measurement in terms of gender and parenting experience was achieved. Overall, fathers scored higher than mothers on demandingness, regardless of their parenting experience. Primiparous mothers scored higher than multiparous mothers and primiparous fathers on the responsiveness dimension. However, there were no gender-based differences on this dimension for parents with more than one child. These results confirm that the TFSQ is an adequate and validated instrument for assessing parenting dimensions, as it performs equally well for mothers and fathers, regardless of their parenting experience. There is also support for the notion that parental attitudes to feeding may be related to their socio-economic background. CI - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Lozano-Casanova, Mar AU - Lozano-Casanova M AD - Nursing Department, University of Alicante, Spain. FAU - Escribano, Silvia AU - Escribano S AD - Nursing Department, University of Alicante, Spain. Electronic address: silvia.escribano@ua.es. FAU - Oliver-Roig, Antonio AU - Oliver-Roig A AD - Nursing Department, University of Alicante, Spain. FAU - Richart-Martinez, Miguel AU - Richart-Martinez M AD - Nursing Department, University of Alicante, Spain. FAU - Sospedra, Isabel AU - Sospedra I AD - Nursing Department, University of Alicante, Spain. LA - eng PT - Journal Article PT - Validation Study DEP - 20240815 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - Male MH - *Fathers/psychology MH - Surveys and Questionnaires MH - *Psychometrics MH - *Feeding Behavior/psychology MH - Adult MH - *Parenting/psychology MH - Child, Preschool MH - *Mothers/psychology MH - Reproducibility of Results MH - Sex Factors MH - Infant OTO - NOTNLM OT - Gender invariance OT - Parental feeding OT - Psychometrics OT - Psychometrics validation OT - Scale COIS- Declaration of competing interest None. EDAT- 2024/08/18 04:43 MHDA- 2024/09/10 00:43 CRDT- 2024/08/17 19:14 PHST- 2024/05/24 00:00 [received] PHST- 2024/08/14 00:00 [revised] PHST- 2024/08/15 00:00 [accepted] PHST- 2024/09/10 00:43 [medline] PHST- 2024/08/18 04:43 [pubmed] PHST- 2024/08/17 19:14 [entrez] AID - S0195-6663(24)00438-0 [pii] AID - 10.1016/j.appet.2024.107635 [doi] PST - ppublish SO - Appetite. 2024 Nov 1;202:107635. doi: 10.1016/j.appet.2024.107635. Epub 2024 Aug 15. PMID- 39150350 OWN - NLM STAT- MEDLINE DCOM- 20250911 LR - 20250912 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) VI - 31 IP - 3 DP - 2025 Sep TI - Adequacy of usual intake of Japanese college athletes in various sports clubs. PG - 1011-1021 LID - 10.1177/02601060241273553 [doi] AB - BackgroundWhile many studies have been published on nutrient intake assessment for performance improvement and deficiency prevention in single-sport athletes, few studies have addressed nutrient intakes in athletes from a various sports.AimThe aim of this study was to determine whether Japanese college athletes meet the Dietary Reference Intakes (DRIs) and sports nutrition recommendations (SNRs).MethodsDietary intake was assessed in 1049 Japanese college athletes from a variety of sports using a validated brief-type self-administered diet history questionnaire. The prevalence of inadequate intakes was estimated by comparing the DRIs and SNRs.ResultsFor protein, riboflavin, niacin, vitamins B-6, vitamins B-12, folate, magnesium, zinc, and copper, <10% of females and males consumed diets that fell below the estimated average requirement (EAR) in the DRIs. A large proportion of female and male college athletes demonstrated intakes that were below the EAR for vitamin A (7.8% and 19.0%, respectively), thiamin (10.4% and 23.9%, respectively), calcium (20.4% and 29.7%, respectively), and iron (24.2% and 2.5%, respectively). Regarding DG for chronic disease prevention in the DRIs, over half of both female and male athletes exceeded the DG for saturated fat acid and sodium, and fell below the DG for dietary fiber. Few of both female and male had intakes below the SNRs for protein and carbohydrates.ConclusionThe results of the present study reveal the nutrient intake status of Japanese college athletes by comparing the DRIs and SNRs. Most meet the SNRs for optimal performance, but not the DRIs for health. FAU - Kakutani, Yuya AU - Kakutani Y AUID- ORCID: 0000-0002-0066-2464 AD - Faculty of Health and Nutrition, Osaka Shoin Women's University, Higashi-Osaka, Osaka, Japan. RINGGOLD: 13012 FAU - Ono, Miho AU - Ono M AD - Institute of Food Sciences & Technologies, Ajinomoto Co., Kawasaki, Kanagawa, Japan. RINGGOLD: 13381 FAU - Sasahara, Ikuko AU - Sasahara I AD - Institute of Food Sciences & Technologies, Ajinomoto Co., Kawasaki, Kanagawa, Japan. RINGGOLD: 13381 FAU - Omi, Naomi AU - Omi N AD - Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan. RINGGOLD: 105215 LA - eng PT - Journal Article DEP - 20240816 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 RN - 0 (Vitamins) RN - Japanese people SB - IM MH - Humans MH - Male MH - Female MH - Japan MH - *Athletes/statistics & numerical data MH - Young Adult MH - *Diet MH - Universities MH - *Recommended Dietary Allowances MH - Nutritional Requirements MH - Adult MH - *Sports Nutritional Physiological Phenomena MH - Nutritional Status MH - Nutrition Assessment MH - Sports MH - Adolescent MH - Diet Surveys MH - Surveys and Questionnaires MH - Vitamins/administration & dosage MH - East Asian People OTO - NOTNLM OT - Athletes OT - nutrient adequacy OT - recommended intakes OT - students OT - usual nutrient intake COIS- Declaration of conflicting interestsThe authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Miho Ono and Ikuko Sasahara are employees of Ajinomoto co., Inc. The other authors have no conflicts of interest to declare. EDAT- 2024/08/16 13:42 MHDA- 2025/09/11 12:30 CRDT- 2024/08/16 09:44 PHST- 2025/09/11 12:30 [medline] PHST- 2024/08/16 13:42 [pubmed] PHST- 2024/08/16 09:44 [entrez] AID - 10.1177/02601060241273553 [doi] PST - ppublish SO - Nutr Health. 2025 Sep;31(3):1011-1021. doi: 10.1177/02601060241273553. Epub 2024 Aug 16. PMID- 39148374 OWN - NLM STAT- MEDLINE DCOM- 20250724 LR - 20250724 IS - 1552-3918 (Electronic) IS - 0163-2787 (Linking) VI - 48 IP - 3 DP - 2025 Sep TI - Validation and Measurement Invariance of the Tendency to Avoid Physical Activity and Sport Scale (TAPAS) Among Thai Young Adults. PG - 308-319 LID - 10.1177/01632787241271117 [doi] AB - Examining ways of reducing physical inactivity has been at the forefront of public health research. Moreover, valid and reliable scales are needed to objectively assess physical activity (PA) avoidance. Previous research has shown that experiencing weight stigma and physical appearance-related concerns are associated with physical inactivity. However, there is currently no Thai instrument that assesses physical inactivity in relation to weight stigma. Therefore, the present study examined the psychometric properties of the Thai version of the Tendency to Avoid Physical Activity and Sport Scale (TAPAS). Thai university students (N = 612) recruited via convenience sampling completed an online survey using SurveyMonkey between September 2022 and January 2023. Confirmatory factor analysis (CFA), multigroup CFA, and Pearson correlations (between TAPAS scores, age, body mass index, and time spent exercising) were used to analyze the data. The CFA showed robust psychometric properties for the Thai version of TAPAS regarding its unidimensional structure. The TAPAS was measurement invariant across sex, weight status, and daily hours of exercise. However, no significant Pearson correlations were found. In general, the results showed that the TAPAS is a good scale for assessing PA avoidance among Thai young adults across different sexes, weight status, and daily hours of exercise. FAU - Ruckwongpatr, Kamolthip AU - Ruckwongpatr K AD - Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Taiwan. RINGGOLD: 34912 FAU - Ahorsu, Daniel Kwasi AU - Ahorsu DK AD - Department of Special Education and Counselling, The Education University of Hong Kong, Hong Kong. RINGGOLD: 66390 FAU - Pimsen, Apiradee AU - Pimsen A AD - Faculty of Nursing, Mahidol University, Thailand. RINGGOLD: 26685 FAU - Paratthakonkun, Chirawat AU - Paratthakonkun C AD - College of Sports Science and Technology, Mahidol University, Thailand. FAU - Tung, Serene En Hui AU - Tung SEH AD - Division of Nutrition and Dietetics, School of Health Sciences, IMU University, Malaysia. RINGGOLD: 50103 FAU - Pramukti, Iqbal AU - Pramukti I AD - Faculty of Nursing, Universitas Padjadjaran, Indonesia. RINGGOLD: 61809 FAU - Bevan, Nadia AU - Bevan N AD - School of Social Sciences, Faculty of Arts, Monash University, Australia. RINGGOLD: 2541 FAU - Chen, Jung-Sheng AU - Chen JS AD - Department of Medical Research, E-Da Hospital, I-Shou University, Taiwan. RINGGOLD: 63344 FAU - Huang, Chi Hsien AU - Huang CH AD - Department of Family Medicine and Community Medicine, E-Da Hospital, I-Shou University, Taiwan. AD - College of Medicine, I-Shou University, Taiwan. FAU - Pakpour, Amir H AU - Pakpour AH AD - Department of Nursing, School of Health and Welfare, Jonkoping University, Sweden. RINGGOLD: 4161 FAU - Griffiths, Mark D AU - Griffiths MD AUID- ORCID: 0000-0001-8880-6524 AD - International Gaming Research Unit, Psychology Department, Nottingham Trent University, UK. RINGGOLD: 6122 FAU - Lin, Chung-Ying AU - Lin CY AUID- ORCID: 0000-0002-2129-4242 AD - Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Taiwan. RINGGOLD: 34912 AD - Faculty of Nursing, Universitas Padjadjaran, Indonesia. RINGGOLD: 61809 AD - Biostatistics Consulting Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Taiwan. LA - eng PT - Journal Article PT - Validation Study DEP - 20240816 PL - United States TA - Eval Health Prof JT - Evaluation & the health professions JID - 7805992 SB - IM MH - Humans MH - Male MH - Female MH - Thailand MH - Psychometrics MH - *Exercise/psychology MH - Young Adult MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - *Sports/psychology MH - Students/psychology MH - Factor Analysis, Statistical MH - Adult MH - Adolescent MH - Body Mass Index MH - Southeast Asian People OTO - NOTNLM OT - TAPAS OT - Thai OT - measurement invariance OT - psychometric properties OT - tendency to avoid physical activity and sport scale OT - university students COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2024/08/16 06:42 MHDA- 2025/07/24 06:32 CRDT- 2024/08/16 03:02 PHST- 2025/07/24 06:32 [medline] PHST- 2024/08/16 06:42 [pubmed] PHST- 2024/08/16 03:02 [entrez] AID - 10.1177/01632787241271117 [doi] PST - ppublish SO - Eval Health Prof. 2025 Sep;48(3):308-319. doi: 10.1177/01632787241271117. Epub 2024 Aug 16. PMID- 39145738 OWN - NLM STAT- MEDLINE DCOM- 20260223 LR - 20260223 IS - 1752-6116 (Electronic) IS - 1476-3141 (Linking) VI - 25 IP - 1 DP - 2026 Jan TI - Agreement between an automated video-based system and tethered system to measure instantaneous swimming velocity. PG - 122-134 LID - 10.1080/14763141.2024.2388572 [doi] AB - Successful performance in competitive swimming requires a swimmer to maximise propulsion and minimise drag, which can be assessed using instantaneous swimming velocity. Many systems exist to quantify velocity, and therefore, it is important to understand the agreement between systems. This study examined the agreement between an automated video-based system and a tethered system to measure instantaneous velocity. Twenty-two competitive swimmers (state level or higher) completed 25 m of each stroke at maximal intensity. The tethered speedometer was attached to the swimmer's waist, while videos of each trial were recorded. The swimmer's head was then automatically tracked using proprietary software, and instantaneous velocity was determined from each system. Bland-Altman plots showed good agreement between the two systems in backstroke (95% Limits of Agreement (LOA): -0.24-0.26 m.s(-1)) and freestyle (95% LOA: -0.36-0.38 m.s(-1)) but poorer agreement in butterfly (95% LOA: -0.51-0.53 m.s(-1)) and breaststroke (95% LOA: -0.88-0.92 m.s(-1)). The root mean square error was higher in butterfly (0.27 m.s(-1)) and breaststroke (0.46 m.s(-1)) compared to backstroke (0.13 m.s(-1)) and freestyle (0.19 m.s(-1)). Results demonstrated that the two systems are comparable for measuring instantaneous swimming velocity; however, larger discrepancies are evident for butterfly and breaststroke. FAU - Scott, Michelle AU - Scott M AD - School of Health, Medical and Applied Sciences, Central Queensland University, Mackay, Queensland, Australia. FAU - Elsworthy, Nathan AU - Elsworthy N AUID- ORCID: 0000-0002-5223-6803 AD - School of Health, Medical and Applied Sciences, Central Queensland University, Mackay, Queensland, Australia. FAU - Brackley, Victoria AU - Brackley V AUID- ORCID: 0000-0003-2926-7385 AD - Victorian Institute of Sport, Melbourne Victoria, Australia. FAU - Elipot, Marc AU - Elipot M AD - Swimming Insight, Swimming Australia, Canberra, Australian Capital Territory, Australia. FAU - Kean, Crystal O AU - Kean CO AUID- ORCID: 0000-0003-0135-7178 AD - School of Health, Medical and Applied Sciences, Central Queensland University, Mackay, Queensland, Australia. AD - Research Institute for Sport and Exercise, Faculty of Health, University of Canberra, Canberra, Australian Capital Territory, Australia. LA - eng PT - Journal Article DEP - 20240815 PL - England TA - Sports Biomech JT - Sports biomechanics JID - 101151352 SB - IM MH - Humans MH - *Swimming/physiology MH - *Video Recording MH - Biomechanical Phenomena MH - Male MH - Young Adult MH - *Athletic Performance/physiology MH - Female MH - Adolescent MH - Time and Motion Studies MH - Adult OTO - NOTNLM OT - Instantaneous swimming velocity OT - automated systems OT - competitive swimmers OT - performance analysis EDAT- 2024/08/15 12:43 MHDA- 2026/02/23 13:05 CRDT- 2024/08/15 10:03 PHST- 2026/02/23 13:05 [medline] PHST- 2024/08/15 12:43 [pubmed] PHST- 2024/08/15 10:03 [entrez] AID - 10.1080/14763141.2024.2388572 [doi] PST - ppublish SO - Sports Biomech. 2026 Jan;25(1):122-134. doi: 10.1080/14763141.2024.2388572. Epub 2024 Aug 15. PMID- 39143295 OWN - NLM STAT- MEDLINE DCOM- 20241123 LR - 20261010 IS - 1476-5497 (Electronic) IS - 0307-0565 (Linking) VI - 48 IP - 12 DP - 2024 Dec TI - The Modified Weight Bias Internalization Scale: measurement invariance by weight status and race among undergraduate women. PG - 1705-1710 LID - 10.1038/s41366-024-01602-7 [doi] AB - BACKGROUND: Internalized weight bias is the belief in negative, weight-based stereotypes and the application of these stereotypes to oneself. These negative stereotypes have harmful impacts on people with overweight/obesity, and weight-based discrimination is well-documented across a variety of settings. Given poor outcomes associated with internalized weight bias, particularly among individuals with obesity, it is necessary to validate measures assessing internalized weight bias among diverse samples. The present study sets out to investigate measurement invariance properties across weight status (women with vs. without overweight/obesity) and race (White vs. Asian; White vs. bi- or multi-racial) of the Modified Weight Bias Internalization Scale (WBIS-M), an 11 item self-report measure. METHODS: Participants were 746 racially/ethnically diverse women across the weight spectrum (24.9% with overweight/obesity). Confirmatory factor analyses of the WBIS-M were initially performed among the full sample, and all sub-samples. Each model showed good to excellent descriptive model fit. Subsequent analyses examined factor loadings and item thresholds of the WBIS-M to assess metric, threshold, and scalar invariance. Invariance was determined by assessing changes in Comparative Fit Index (DeltaCFI /= 0.30 and < 0.85), communality (> 0.20), model fit indices - Tucker-Lewis index (TLI) > 0.90, and root mean square error of approximation (RMSEA) < 0.08. A critical analysis of the form items was performed to adjust the parameters. Measurement stability was investigated between age groups, macro-regions and longitudinally by multi-group confirmatory factor analysis in configural, metric, and scalar invariance models. Configural invariance was accepted if RMSEA < 0.08 and TLI and comparative fit index (CFI) > 0.90. Metric and scalar invariances were accepted if DeltaRMSEA < 0.015 and DeltaCFI < 0.01, compared to the previous model. RESULTS: After critical analysis, items were grouped (vegetables and leafy greens; meat or eggs and liver) and excluded (salty food; porridge with milk; rice, potatoes, yams, cassava, flour, or pasta). The exploratory model comprised three factors: healthy complementary feeding (fruit; vegetables; orange or dark green leafy vegetables or fruits; meat, offal, or egg; beans), ultra-processed (yogurt; hamburger and/or sausages; sweetened drinks; instant noodles, packet snacks, or salty cookies; sandwich cookies, sweets, or treats), and milk feeding (breast milk; other milk), with satisfactory factor loadings, communalities and fit (TLI: 0.918, RMSEA: 0.071). The reformulated instrument was stable in the invariance models tested. CONCLUSIONS: With the incorporation of the modifications to the Sisvan form, the food intake markers subsidize a more adequate interpretation of the feeding situation of children aged six to 23 months. FAU - Guedes, Bianca de Melo AU - Guedes BM AUID- ORCID: 0000-0002-6903-1265 AD - Universidade de Sao Paulo. Faculdade de Saude Publica. Programa de Pos-Graduacao Nutricao em Saude Publica. Sao Paulo, SP, Brasil. FAU - Santos, Thanise Sabrina Souza AU - Santos TSS AUID- ORCID: 0000-0003-4087-1815 AD - Universidade de Sao Paulo. Faculdade de Saude Publica. Nucleo de Pesquisas Epidemiologicas em Nutricao e Saude. Sao Paulo, SP, Brasil. FAU - Leffa, Paula Dos Santos AU - Leffa PDS AUID- ORCID: 0000-0001-8745-1135 AD - Ministerio da Saude. Coordenacao de Gestao de Projetos de Pesquisa. Brasilia, DF, Brasil. FAU - Silva, Sara Araujo da AU - Silva SAD AUID- ORCID: 0000-0002-2605-378X AD - Ministerio da Saude. Coordenacao-Geral de Alimentacao e Nutricao. Brasilia, DF, Brasil. FAU - Lourenco, Barbara Hatzlhoffer AU - Lourenco BH AUID- ORCID: 0000-0002-2006-674X AD - Universidade de Sao Paulo. Faculdade de Saude Publica. Departamento de Nutricao. Sao Paulo, SP, Brasil. LA - eng LA - por PT - Journal Article PT - Validation Study DEP - 20240809 PL - Brazil TA - Rev Saude Publica JT - Revista de saude publica JID - 0135043 SB - IM MH - Humans MH - Infant MH - Brazil MH - Factor Analysis, Statistical MH - *Nutrition Surveys MH - Female MH - Male MH - Eating/physiology MH - Reproducibility of Results MH - Feeding Behavior/physiology PMC - PMC11319038 COIS- Conflict of Interest: The authors declare no conflict of interest. EDAT- 2024/08/14 12:41 MHDA- 2024/08/14 12:42 PMCR- 2024/07/22 CRDT- 2024/08/14 08:13 PHST- 2023/09/12 00:00 [received] PHST- 2024/03/10 00:00 [accepted] PHST- 2024/08/14 12:42 [medline] PHST- 2024/08/14 12:41 [pubmed] PHST- 2024/08/14 08:13 [entrez] PHST- 2024/07/22 00:00 [pmc-release] AID - S0034-89102024000100230 [pii] AID - 10.11606/s1518-8787.2024058005811 [doi] PST - epublish SO - Rev Saude Publica. 2024 Aug 9;58:35. doi: 10.11606/s1518-8787.2024058005811. eCollection 2024. PMID- 39134756 OWN - NLM STAT- MEDLINE DCOM- 20250507 LR - 20260830 IS - 1530-0447 (Electronic) IS - 0031-3998 (Print) IS - 0031-3998 (Linking) VI - 97 IP - 3 DP - 2025 Feb TI - Using weight-for-age as a screening tool for metabolic syndrome in apparently healthy adolescents. PG - 994-1000 LID - 10.1038/s41390-024-03465-0 [doi] AB - BACKGROUND: The increasing prevalence of metabolic syndrome (MetS) among adolescents necessitates a simple and easy-to-use screening tool. This study aimed to develop and validate a simple model based on age, sex, race, and weight-for-age or BMI-for-age to identify adolescents with MetS. METHODS: A cross-sectional study of adolescents (aged 12-18 years) who participated in the American National Health and Nutrition Examination Survey (NHANES) was performed. Participants with pre-existing hypertension, diabetes or dyslipidemia were excluded. Data from 2005-2018 were randomly divided into training (70%) and validation (30%) sets. Anthropometric, demographic data, and MetS criteria were extracted. RESULTS: The training group included 1974 adolescents (52% boys, median age 15 years), and the validation group included 848 adolescents (50% boys, median age 14 years). Both weight- and BMI-for-age demonstrated good discrimination ability in the training group (AUC = 0.897 and 0.902, respectively), with no significant difference between them (p = 0.344). Multivariable models showed similar discrimination ability. Therefore, weight-for-age was chosen and using Youden's index, the 93rd weight-for-age percentile (SDS 1.5) was identified as the optimal cut-off value for MetS. Similar values were observed in the validation group. CONCLUSIONS: Among adolescents aged 12-18 years, weight-for-age percentiles are an easy-to-use primary screening indicator for the presence of MetS. IMPACT: The prevalence of metabolic syndrome in adolescents is increasing. An early detection screening tool is required to prevent related adulthood morbidity. Screening adolescents for metabolic syndrome is challenging. This study suggests the use of weight-for-age as a single criterion for primary screening of adolescents aged 12-18. Using weight-for-age as a single predictor of metabolic syndrome is expected to increase screening rates compared to using BMI-for-age, due to its simplicity. CI - (c) 2024. The Author(s). FAU - Oselka, Noa AU - Oselka N AD - School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Dubnov-Raz, Gal AU - Dubnov-Raz G AD - School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel. AD - Sheba Medical Center, Ramat-Gan, Israel. FAU - Ziv-Baran, Tomer AU - Ziv-Baran T AD - School of Public Health, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel. zivtome@tauex.tau.ac.il. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240812 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM MH - Humans MH - *Metabolic Syndrome/diagnosis/epidemiology MH - Adolescent MH - Male MH - Female MH - Child MH - Cross-Sectional Studies MH - Body Mass Index MH - *Mass Screening/methods MH - Nutrition Surveys MH - *Body Weight MH - Prevalence MH - Age Factors PMC - PMC12055599 COIS- Competing interests: The authors declare no competing interests. Patient consent: This study is based on anonymized data from the National Health and Nutrition Examination Survey (NHANES) database. Therefore, informed consent was waived. EDAT- 2024/08/13 00:41 MHDA- 2025/05/07 06:27 PMCR- 2024/08/12 CRDT- 2024/08/12 23:30 PHST- 2024/04/24 00:00 [received] PHST- 2024/07/15 00:00 [accepted] PHST- 2024/07/11 00:00 [revised] PHST- 2025/05/07 06:27 [medline] PHST- 2024/08/13 00:41 [pubmed] PHST- 2024/08/12 23:30 [entrez] PHST- 2024/08/12 00:00 [pmc-release] AID - 10.1038/s41390-024-03465-0 [pii] AID - 3465 [pii] AID - 10.1038/s41390-024-03465-0 [doi] PST - ppublish SO - Pediatr Res. 2025 Feb;97(3):994-1000. doi: 10.1038/s41390-024-03465-0. Epub 2024 Aug 12. PMID- 39125370 OWN - NLM STAT- MEDLINE DCOM- 20240810 LR - 20240812 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 15 DP - 2024 Jul 31 TI - Development and Evaluation of the Reliability of a Semi-Quantitative Food Frequency Questionnaire to Assess the Intake in the Serbian Population. LID - 10.3390/nu16152490 [doi] LID - 2490 AB - Assessing dietary habits with validated questionnaires is crucial for achieving reliable results in health research. The aim of this study was the development and validation of a semi-quantitative food frequency questionnaire (FFQ) in an 18-30-year-old Serbian population. A total of 93 participants completed the FFQ and three 24 h dietary recalls (24 hR). Pearson and intraclass correlations between FFQ and 24 hR intakes were assessed and were de-attenuated and energy-adjusted. Bland-Altman plots were generated, and quintiles of energy, water, fiber, and macronutrient intake were analyzed with contingency tables. Adjustments for sex differences were included. The validity of the FFQ varied, with significant correlations for energy, carbohydrates, cholesterol, and vitamin B(12), vitamin C and vitamin D. Misclassification rates were generally low. Bland-Altman plots indicated good agreement between methods. It can be concluded that the validated FFQ is a promising tool for dietary assessment in the Serbian population. Results for several nutrients align closely with previous studies. The new FFQ is a useful tool for dietary assessment in the Serbian population. FAU - Garcia, Silvia AU - Garcia S AUID- ORCID: 0000-0003-3534-1588 AD - Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - Health Institute of the Balearic Islands (IDISBA), 07120 Palma de Mallorca, Spain. AD - CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain. FAU - Vidovic, Bojana AU - Vidovic B AUID- ORCID: 0000-0001-6644-6230 AD - Department of Bromatology, Faculty of Pharmacy, University of Belgrade, 11221 Belgrade, Serbia. FAU - Tijerina, Alexandra AU - Tijerina A AUID- ORCID: 0000-0002-3154-2633 AD - Faculty of Public Health and Nutrition, Autonomous University of Nuevo Leon, Monterrey 64460, Mexico. FAU - Tur, Josep A AU - Tur JA AUID- ORCID: 0000-0002-6940-0761 AD - Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - Health Institute of the Balearic Islands (IDISBA), 07120 Palma de Mallorca, Spain. AD - CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain. FAU - Bouzas, Cristina AU - Bouzas C AUID- ORCID: 0000-0002-1407-8461 AD - Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - Health Institute of the Balearic Islands (IDISBA), 07120 Palma de Mallorca, Spain. AD - CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain. LA - eng GR - CIBEROBN CB12/03/30038/Instituto de Salud Carlos III/ GR - N/A/European Regional Development Fund/ PT - Journal Article PT - Validation Study DEP - 20240731 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Serbia MH - Female MH - Male MH - Adult MH - Reproducibility of Results MH - Young Adult MH - Adolescent MH - *Diet Surveys/standards/methods MH - Surveys and Questionnaires/standards MH - *Feeding Behavior MH - Diet/statistics & numerical data MH - Nutrition Assessment MH - Energy Intake PMC - PMC11313923 OTO - NOTNLM OT - 24 h recall OT - Serbia OT - food frequency questionnaire OT - nutrients OT - validation COIS- The authors declare no conflicts of interest. EDAT- 2024/08/10 15:43 MHDA- 2024/08/10 15:44 PMCR- 2024/07/31 CRDT- 2024/08/10 01:13 PHST- 2024/06/29 00:00 [received] PHST- 2024/07/26 00:00 [revised] PHST- 2024/07/29 00:00 [accepted] PHST- 2024/08/10 15:44 [medline] PHST- 2024/08/10 15:43 [pubmed] PHST- 2024/08/10 01:13 [entrez] PHST- 2024/07/31 00:00 [pmc-release] AID - nu16152490 [pii] AID - nutrients-16-02490 [pii] AID - 10.3390/nu16152490 [doi] PST - epublish SO - Nutrients. 2024 Jul 31;16(15):2490. doi: 10.3390/nu16152490. PMID- 39125275 OWN - NLM STAT- MEDLINE DCOM- 20240810 LR - 20240812 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 15 DP - 2024 Jul 24 TI - Home Enteral Nutrition in Patients with Cerebral Palsy in the Years 2012-2022: A Longitudinal Analysis of Data from the National Health Fund of Poland. LID - 10.3390/nu16152394 [doi] LID - 2394 AB - BACKGROUND: Cerebral palsy (CP) often correlates with a higher risk of malnutrition, negatively affecting the quality of life of patients and their families. Enteral nutrition via a feeding tube should be considered to improve the nutritional status of CP patients. To date, there has been no nationwide registry of patients with CP in Poland. This study aimed to assess the prevalence of home enteral nutrition (HEN) provision in pediatric and adult patients with CP. METHODS: We retrospectively analyzed data from the Polish National Health Fund (NFZ) on the provision of HEN in patients with CP in 2012-2022. A specially designed and validated questionnaire was sent to the 16 regional branches of NFZ. RESULTS: Completed questionnaires were sent back from 12 NFZ branches. In 2022, CP cases increased by 7%, primarily among adults, while pediatric cases dropped by 21%. Despite a rising trend, the proportion of patients receiving HEN remained relatively low. Among children, it increased from 2.1% in 2012 to 3.3-3.5% in 2019-2021. For adults, it nearly doubled from 0.8% in 2012 to 1.7% in 2022. The prevalence of enteral feeding correlated with patient age, with a noticeable increase among older children and adolescents. CONCLUSIONS: National Health Fund data highlight the need for a nationwide registry of patients with CP. A relatively small proportion of pediatric and adult CP patients receive HEN. Increasing clinicians' awareness of HEN availability is necessary to improve the quality of life for more CP patients. FAU - Zagierski, Maciej AU - Zagierski M AD - Department of Paediatrics, Gastroenterology, Allergology & Paediatric Nutrition, Medical University of Gdansk, 80-210 Gdansk, Poland. FAU - Gorska, Angelika AU - Gorska A AD - Nutricia Polska Sp. z o.o., ul. Bobrowiecka 8, 00-728 Warsaw, Poland. FAU - Zagierska, Agnieszka AU - Zagierska A AD - Department of Paediatrics, Gastroenterology, Allergology & Paediatric Nutrition, Medical University of Gdansk, 80-210 Gdansk, Poland. FAU - Augustynska, Joanna AU - Augustynska J AD - EconMed Europe, Mlynska 9/4, 31-469 Krakow, Poland. FAU - Seweryn, Michal AU - Seweryn M AD - Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, Gustawa Herlinga-Grudzinskiego 1, 30-705 Krakow, Poland. FAU - Szlagatys-Sidorkiewicz, Agnieszka AU - Szlagatys-Sidorkiewicz A AUID- ORCID: 0000-0002-5992-4414 AD - Department of Paediatrics, Gastroenterology, Allergology & Paediatric Nutrition, Medical University of Gdansk, 80-210 Gdansk, Poland. LA - eng PT - Journal Article DEP - 20240724 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Enteral Nutrition/statistics & numerical data MH - Poland/epidemiology MH - *Cerebral Palsy/therapy/epidemiology MH - Adolescent MH - Child MH - Adult MH - Male MH - Retrospective Studies MH - Female MH - Young Adult MH - Child, Preschool MH - Longitudinal Studies MH - Home Care Services/statistics & numerical data MH - Surveys and Questionnaires MH - Quality of Life MH - Nutritional Status MH - Middle Aged MH - Infant MH - Registries PMC - PMC11314170 OTO - NOTNLM OT - cerebral palsy OT - enteral nutrition OT - home enteral nutrition OT - malnutrition OT - tube feeding COIS- Author A.G. is employee of the company Nutricia Polska Sp. z o.o. Authors J.A. and M.S. are employees of the company EconMed Europe. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/08/10 15:45 MHDA- 2024/08/10 15:46 PMCR- 2024/07/24 CRDT- 2024/08/10 01:12 PHST- 2024/05/28 00:00 [received] PHST- 2024/07/17 00:00 [revised] PHST- 2024/07/18 00:00 [accepted] PHST- 2024/08/10 15:46 [medline] PHST- 2024/08/10 15:45 [pubmed] PHST- 2024/08/10 01:12 [entrez] PHST- 2024/07/24 00:00 [pmc-release] AID - nu16152394 [pii] AID - nutrients-16-02394 [pii] AID - 10.3390/nu16152394 [doi] PST - epublish SO - Nutrients. 2024 Jul 24;16(15):2394. doi: 10.3390/nu16152394. PMID- 39123316 OWN - NLM STAT- MEDLINE DCOM- 20241205 LR - 20260607 IS - 1099-0968 (Electronic) IS - 1072-4133 (Print) IS - 1072-4133 (Linking) VI - 33 IP - 1 DP - 2025 Jan TI - Food intake and eating behaviour during a real-life Snack Scenario in childhood obesity-An experiment using a hidden camera. PG - 67-79 LID - 10.1002/erv.3130 [doi] AB - OBJECTIVE: To compare food intake and eating behaviour in children and adolescents with obesity (OBE) undergoing weight loss intervention and normal weight (NW) in a real-life Snack Scenario. METHODS: Sixty OBE were examined before (T0) and after weight loss (T1) and compared to a single measurement comparison group of 27 NW. Participants watched a 20-min film and were encouraged to snack from a variety of foods ad libitum. Food intake was measured and eating behaviour assessed via a hidden camera and a validated questionnaire. RESULTS: The food and energy intake did not differ between NW (155 +/- 83 g, 1067 +/- 732 kJ) and OBE at T0 (144 +/- 106 g, 1088 +/- 883 kJ) but increased in OBE at T1 (187 +/- 91 g, 1544 +/- 845 kJ). Latency of food intake was significantly shorter in NW (0 m:07 s +/- 0 m:08 s) compared to OBE (T0: 1 m:11 s +/- 2 m:57 s). After weight loss, latency decreased in OBE (0 m:26 s +/- 1 m:00 s). NW touched food more often (49 +/- 24) than OBE (T0: 29 +/- 23), but takes from plate were similar. The questionnaire revealed differences between OBE and NW, not correlating with Snack Scenario observations. CONCLUSION: Eating behaviours differed in NW versus OBE at T0 but food intake was similar. Therefore, behaviour while eating may be an underestimated factor in the considerations for childhood obesity. CLINICAL TRIAL REGISTRATION: German Clinical Trials Register (DRKS) with the trial number DRKS00005122. CI - (c) 2024 The Author(s). European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd. FAU - Mack, Isabelle AU - Mack I AD - Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tubingen, Tubingen, Germany. FAU - Godwin, Jessica AU - Godwin J AD - Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tubingen, Tubingen, Germany. FAU - Klos, Bea AU - Klos B AD - Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tubingen, Tubingen, Germany. FAU - Sauer, Helene AU - Sauer H AD - Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tubingen, Tubingen, Germany. FAU - Weiland, Alisa AU - Weiland A AD - Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tubingen, Tubingen, Germany. FAU - Horing, Bjorn AU - Horing B AD - Department of Systems Neuroscience, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany. FAU - Zipfel, Stephan AU - Zipfel S AD - Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tubingen, Tubingen, Germany. FAU - Enck, Paul AU - Enck P AD - Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tubingen, Tubingen, Germany. FAU - Mazurak, Nazar AU - Mazurak N AD - Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tubingen, Tubingen, Germany. LA - eng GR - Else Kroner-Fresenius-Stiftung/ PT - Journal Article PT - Observational Study DEP - 20240809 PL - England TA - Eur Eat Disord Rev JT - European eating disorders review : the journal of the Eating Disorders Association JID - 9436977 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Eating/psychology/physiology MH - Energy Intake/physiology MH - *Feeding Behavior/psychology MH - *Pediatric Obesity/psychology MH - *Snacks/psychology MH - Surveys and Questionnaires MH - Weight Loss/physiology PMC - PMC11617800 OTO - NOTNLM OT - adolescents OT - childhood obesity OT - children OT - eating behaviour OT - obesity COIS- The authors declare no conflict of interest. EDAT- 2024/08/10 15:43 MHDA- 2024/12/05 06:23 PMCR- 2024/12/05 CRDT- 2024/08/10 00:42 PHST- 2024/07/05 00:00 [revised] PHST- 2024/01/31 00:00 [received] PHST- 2024/08/02 00:00 [accepted] PHST- 2024/12/05 06:23 [medline] PHST- 2024/08/10 15:43 [pubmed] PHST- 2024/08/10 00:42 [entrez] PHST- 2024/12/05 00:00 [pmc-release] AID - ERV3130 [pii] AID - 10.1002/erv.3130 [doi] PST - ppublish SO - Eur Eat Disord Rev. 2025 Jan;33(1):67-79. doi: 10.1002/erv.3130. Epub 2024 Aug 9. PMID- 39118355 OWN - NLM STAT- MEDLINE DCOM- 20241119 LR - 20260708 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 20 IP - 4 DP - 2024 Oct TI - Development and validation of a tool to assess underlying factors of iron-rich food consumption among pregnant women. PG - e13692 LID - 10.1111/mcn.13692 [doi] LID - e13692 AB - Anaemia among pregnant women remains a public health concern globally. One major cause of this persistent problem is iron deficiency, which may be the result of limited iron intake in the diet. Using the extended version of the theory of planned behaviour (eTPB), this study aims to develop and validate a questionnaire assessing psychosocial and environmental factors that could influence the consumption of iron-rich foods (IRFs) among Senegalese pregnant women. A three-step procedure was used. Six focus group discussions (FGDs) were held with 10 pregnant women each from a different region to identify salient beliefs related to each of the four constructs of the eTPB using a structured guide. Information from FGDs was used to develop a questionnaire, which was administered to the first group (n = 200) of pregnant women. Principal component analyses and exploratory factorial analyses were performed on the first set of data to identify latent factors for each construct namely the attitude, subjective norm and perceived behavioural control. A revised and shorter version of the questionnaire was administered to a second sample of pregnant women (n = 226) and confirmatory factorial analyses were conducted using this second set of data. Hancock and Muller's H reliability index was computed on the final model. The final questionnaire included 44 items. Most criteria for fit indices were met and H values were satisfactory. This study proposes a tool that could be used to explore determinants of the consumption of IRF among pregnant women. Further validation is still warranted in other contexts. CI - (c) 2024 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Mohamadou, Sall AU - Mohamadou S AD - Institut de recherche population, developpement et sante de la reproduction, Universite Cheikh Anta Diop, Dakar, Senegal. FAU - Aminata, Ndiaye Ndene AU - Aminata NN AD - Institut de recherche population, developpement et sante de la reproduction, Universite Cheikh Anta Diop, Dakar, Senegal. FAU - Jeremie Bobby, Dupuis AU - Jeremie Bobby D AD - Vice-rectorat a l'enseignement et a la recherche, Universite de Moncton, Moncton, New Brunswick, Canada. FAU - Nafissatou, Ba Lo AU - Nafissatou BL AD - Conseil national de developpement de la nutrition, Dakar, Senegal. FAU - Momar, Thiam El Hadj AU - Momar TEH AD - Conseil national de developpement de la nutrition, Dakar, Senegal. FAU - Sonia, Blaney AU - Sonia B AD - Ecole de nutrition, Universite Laval, Quebec, Quebec, Canada. LA - eng GR - Comite National de developpement de la Nutrition du Senegal/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20240808 PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 RN - 0 (Iron, Dietary) SB - IM MH - Humans MH - Female MH - Pregnancy MH - Adult MH - Surveys and Questionnaires/standards MH - *Iron, Dietary/administration & dosage MH - Young Adult MH - *Focus Groups MH - Reproducibility of Results MH - Health Knowledge, Attitudes, Practice MH - Senegal MH - Diet/methods/statistics & numerical data MH - Anemia, Iron-Deficiency MH - Pregnant People/psychology MH - Adolescent MH - Feeding Behavior/psychology PMC - PMC11574646 OTO - NOTNLM OT - Senegal OT - assessment OT - consumption during pregnancy OT - iron-rich foods OT - maternal nutrition OT - questionnaire OT - tool COIS- The authors declare no conflict of interest. EDAT- 2024/08/09 06:42 MHDA- 2024/11/19 13:18 PMCR- 2024/08/08 CRDT- 2024/08/09 01:53 PHST- 2024/05/28 00:00 [revised] PHST- 2024/01/08 00:00 [received] PHST- 2024/06/11 00:00 [accepted] PHST- 2024/11/19 13:18 [medline] PHST- 2024/08/09 06:42 [pubmed] PHST- 2024/08/09 01:53 [entrez] PHST- 2024/08/08 00:00 [pmc-release] AID - MCN13692 [pii] AID - 10.1111/mcn.13692 [doi] PST - ppublish SO - Matern Child Nutr. 2024 Oct;20(4):e13692. doi: 10.1111/mcn.13692. Epub 2024 Aug 8. PMID- 39113943 OWN - NLM STAT- MEDLINE DCOM- 20240808 LR - 20240829 IS - 2046-1402 (Electronic) IS - 2046-1402 (Linking) VI - 13 DP - 2024 TI - Effect of a pragmatic lifestyle modification intervention on physical activity levels and body mass index among obese and overweight adolescents in Udupi, India: a cluster randomized trial. PG - 859 LID - 10.12688/f1000research.153483.1 [doi] LID - 859 AB - BACKGROUND: Determine the effects of a multifactorial lifestyle intervention on physical activity (PA), BMI and health-related quality of life (QoL) in obese and overweight adolescents. METHODS: Nine schools in India were clustered randomly in a 12-month study with students allocated to a multifactorial intervention (MFI), or exercise only (EX) or control (CON) group. Participants were adolescents aged 11-16 years (n=671). In the MFI group, adolescents and their parents received lifestyle education using a validated booklet combined with a PA intervention for school students. The EX group received school-based PA only; the CON group continued regular activities. Primary outcomes were PA levels measured with the PAQ-A, and BMI; the secondary outcome was health-related QoL. A linear regression statistical model was used to analyse time, group effects and interactions, with Bonferroni correction for within-group differences at baseline (T0) and at 12-weeks (T1) (post-intervention), 6-month (T2) and 12-month (T3) follow-ups. RESULTS: Significant time and group effects observed for all groups with PA scores (p<0.001), with MFI group having largest increase in PA; with BMI (p<0.001) and MFI showing the least gain in BMI; and HRQOL (p<0.001), with MFI group showing greatest improvement in scores. There were significant increases in PA at T1 and T3 time-points with the EX group, and at T3 time-point only for MFI and CON, with MFI group showing largest increase in HRQOL scores. BMI increased significantly for all groups at T2 (MFI p=0.001, EX p<0.001) and T3 (p<0.001), while HRQOL increased significantly for both MFI and EX at both follow-ups (p<0.001). CONCLUSIONS: School-based lifestyle MFI was more effective for improving PA, lifestyle behaviours and HRQOL than exercise alone for adolescents, although BMI was not reduced. MFI with PA could be an effective school-based approach for behaviour modification but BMI has limitations for measuring body composition changes. REGISTRATION: CTRI/2019/04/018834 (30/04/2019). CI - Copyright: (c) 2024 srivastav p et al. FAU - Srivastav, Prateek AU - Srivastav P AUID- ORCID: 0000-0001-8836-6426 AD - Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. FAU - K, Vaishali AU - K V AUID- ORCID: 0000-0001-5746-1682 AD - Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. FAU - Bhat, H Vinod AU - Bhat HV AD - The Apollo University, Chittoor, Andhra Pradesh, 517127, India. FAU - Broadbent, Suzanne AU - Broadbent S AD - School of Health, University of Sunshine Coast, Sippy Downs, Queensland, 4556, Australia. LA - eng SI - figshare/10.6084/m9.figshare.26123824 PT - Journal Article PT - Randomized Controlled Trial DEP - 20240801 PL - England TA - F1000Res JT - F1000Research JID - 101594320 SB - IM MH - Humans MH - Adolescent MH - India MH - *Body Mass Index MH - Female MH - *Exercise MH - Male MH - Child MH - *Quality of Life MH - *Overweight/therapy MH - Life Style MH - Obesity/therapy MH - Pediatric Obesity/therapy PMC - PMC11303949 OTO - NOTNLM OT - Adolescents OT - diet OT - health education OT - lifestyle OT - parents OT - physical activity OT - school COIS- No competing interests were disclosed. EDAT- 2024/08/08 06:42 MHDA- 2024/08/08 06:43 PMCR- 2024/08/01 CRDT- 2024/08/08 04:27 PHST- 2024/07/17 00:00 [accepted] PHST- 2024/08/08 06:43 [medline] PHST- 2024/08/08 06:42 [pubmed] PHST- 2024/08/08 04:27 [entrez] PHST- 2024/08/01 00:00 [pmc-release] AID - 10.12688/f1000research.153483.1 [doi] PST - epublish SO - F1000Res. 2024 Aug 1;13:859. doi: 10.12688/f1000research.153483.1. eCollection 2024. PMID- 39111086 OWN - NLM STAT- MEDLINE DCOM- 20240830 LR - 20240830 IS - 1873-7358 (Electronic) IS - 1471-0153 (Linking) VI - 54 DP - 2024 Aug TI - Measurement invariance of the Intuitive Eating Scale-2 across country, ethnicity, sex, and sexual orientation: A cross-cultural study between Brazil and the U.S. PG - 101904 LID - S1471-0153(24)00063-1 [pii] LID - 10.1016/j.eatbeh.2024.101904 [doi] AB - Intuitive eating is defined as being connected to internal hunger, satiety, and appetitive cues and flexibly using these cues to determine when, what, and how much to eat. The Intuitive Eating Scale-2 (IES-2) is a widely used measure of facets of intuitive eating. However, the scale has shown unstable factor structure in several validation studies and there is a lack of studies investigating the measurement invariance of the IES-2 beyond sex. We aimed to evaluate the psychometric properties of the IES-2, testing several factor structures among Brazilian and U.S. samples of men and women; to test measurement invariance across country of origin, ethnicity, sex, and sexual orientation; and to evaluate its internal consistency. Three models of the latent structure of the IES-2 were tested using confirmatory factor analyses (CFA) in a total of 1072 young adults (452 Brazilians and 620 Americans), aged 18-35 years. Results demonstrated that only a 3-factor solution with 11 items of the IES-2 showed adequate fit to the data for both countries. This model demonstrated scalar invariance across sex and sexual orientation, but only configural invariance was found across country of origin and ethnicity. Good internal consistencies were found for both the Brazilian and American samples. The present study provides support for a 3-factor solution with 11 items of the IES-2, to Brazilian and American samples. The study also offers evidence of internal consistency, and invariance between sex (i.e., male and female) and sexual orientation (i.e., heterosexual participants and sexual minority participants). CI - Copyright (c) 2024 Elsevier Ltd. All rights reserved. FAU - Bazo Perez, Maria AU - Bazo Perez M AD - Department of Psychology, Florida International University, Miami, FL, USA. Electronic address: mbazo002@fiu.edu. FAU - Frazier, Leslie D AU - Frazier LD AD - Department of Psychology, Florida International University, Miami, FL, USA. Electronic address: frazier@fiu.edu. FAU - Campos, Priscila Figueiredo AU - Campos PF AD - NICTA, Body Image and Eating Disorders Research Group, Federal University of Juiz de Fora, Governador Valadares, Brazil. FAU - Resende, Thaina Richelli Oliveira AU - Resende TRO AD - NICTA, Body Image and Eating Disorders Research Group, Federal University of Juiz de Fora, Governador Valadares, Brazil. FAU - de Carvalho, Pedro Henrique Berbert AU - de Carvalho PHB AD - NICTA, Body Image and Eating Disorders Research Group, Federal University of Juiz de Fora, Governador Valadares, Brazil; AMBULIM, Eating Disorders Program, Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: pedro.berbert@ufjf.br. LA - eng PT - Journal Article DEP - 20240731 PL - United States TA - Eat Behav JT - Eating behaviors JID - 101090048 SB - IM MH - Humans MH - Male MH - Brazil/ethnology MH - Female MH - *Cross-Cultural Comparison MH - Adult MH - United States/ethnology MH - Young Adult MH - *Psychometrics/instrumentation MH - Adolescent MH - *Sexual Behavior/psychology/ethnology MH - Factor Analysis, Statistical MH - Feeding Behavior/psychology/ethnology MH - Intuition MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Sex Factors OTO - NOTNLM OT - Adaptative eating OT - Cross-cultural comparison OT - Gender minorities OT - Intuitive eating OT - Psychometric properties OT - Sexual minorities COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/08/08 00:42 MHDA- 2024/08/31 09:46 CRDT- 2024/08/07 18:02 PHST- 2024/03/22 00:00 [received] PHST- 2024/07/23 00:00 [revised] PHST- 2024/07/29 00:00 [accepted] PHST- 2024/08/31 09:46 [medline] PHST- 2024/08/08 00:42 [pubmed] PHST- 2024/08/07 18:02 [entrez] AID - S1471-0153(24)00063-1 [pii] AID - 10.1016/j.eatbeh.2024.101904 [doi] PST - ppublish SO - Eat Behav. 2024 Aug;54:101904. doi: 10.1016/j.eatbeh.2024.101904. Epub 2024 Jul 31. PMID- 39108157 OWN - NLM STAT- MEDLINE DCOM- 20240925 LR - 20260723 IS - 1536-4801 (Electronic) IS - 0277-2116 (Linking) VI - 79 IP - 3 DP - 2024 Sep TI - Dietary habits in Italian children with inflammatory bowel disease: A case-control multicenter study. PG - 602-609 LID - 10.1002/jpn3.12344 [doi] AB - OBJECTIVES: Patients with inflammatory bowel disease (IBD) tend to self-modify their dietary habits according to disease activity and symptoms. This study aimed to assess the adequacy of the usual diet in Italian children with IBD in comparison to a control group and to the recommended dietary allowances (RDA). METHODS: Dietary habits of IBD children and age- and gender-matched healthy controls were investigated using a validated Food Frequency Questionnaire in five Italian pediatric IBD centers. Adherence to the Mediterranean diet (MD) was assessed using the KID-MED test. Energy (EI), macro, and micronutrients intakes were compared between the two groups, to the RDA and the predicted total energy expenditure (EI/total energy expenditure [TEE]%). RESULTS: IBD subjects (n = 110) reported a lower EI, EI/RDA%, and EI/TEE% compared to controls (n = 110) (p = 0.012, p < 0.0002, and p = 0.014), lower total protein and fat intakes (p = 0.017, p < 0.0001) and lower minerals/RDA, vitamins/RDA and micronutrients/RDA ratio (%). Poor adherence to the MD was more frequent in IBD children compared to controls (p = 0.013). The total EI and carbohydrate intake were inversely correlated with higher disease activity. CONCLUSIONS: Italian children with IBD report an inadequate diet in terms of energy, macro, and micronutrients and have a low adherence to a high-quality MD pattern. CI - (c) 2024 The Author(s). Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Gatti, Simona AU - Gatti S AUID- ORCID: 0000-0002-5923-5213 AD - Department of Pediatrics, Polytechnic University of Marche, G. Salesi Children's Hospital, Ancona, Italy. FAU - Vallorani, Martina AU - Vallorani M AD - Department of Pediatrics, Polytechnic University of Marche, G. Salesi Children's Hospital, Ancona, Italy. FAU - Quattrini, Sara AU - Quattrini S AD - Department of Pediatrics, Polytechnic University of Marche, G. Salesi Children's Hospital, Ancona, Italy. FAU - Aloi, Marina AU - Aloi M AD - Department of Maternal and Child Health, Pediatric Gastroenterology and Liver Unit, Umberto I Hospital, Sapienza University of Rome, Rome, Italy. FAU - Bramuzzo, Matteo AU - Bramuzzo M AD - Gastroenterology, Digestive Endoscopy and Nutrition Unit, Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy. FAU - Felici, Enrico AU - Felici E AD - Pediatric and Pediatric Emergency Unit, Children Hospital, AO SS Antonio e Biagio e C. Arrigo, Alessandria, Italy. FAU - Zuin, Giovanna AU - Zuin G AD - Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy. FAU - Catassi, Giulia Naspi AU - Catassi GN AD - Department of Maternal and Child Health, Pediatric Gastroenterology and Liver Unit, Umberto I Hospital, Sapienza University of Rome, Rome, Italy. FAU - Grazian, Federica AU - Grazian F AD - University of Trieste, Trieste, Italy. FAU - Ciacchini, Benedetta AU - Ciacchini B AD - Department of Health Science, Division of Pediatrics, University of Piemonte Orientale, Novara, Italy. FAU - Panceri, Roberto AU - Panceri R AD - Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy. FAU - Catassi, Carlo AU - Catassi C AD - Department of Pediatrics, Polytechnic University of Marche, G. Salesi Children's Hospital, Ancona, Italy. LA - eng GR - None/ PT - Journal Article PT - Multicenter Study DEP - 20240806 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 RN - 0 (Micronutrients) SB - IM MH - Humans MH - Male MH - Female MH - Italy/epidemiology MH - Case-Control Studies MH - Child MH - *Feeding Behavior MH - Adolescent MH - *Diet, Mediterranean/statistics & numerical data MH - *Inflammatory Bowel Diseases MH - Energy Intake MH - Recommended Dietary Allowances MH - Patient Compliance/statistics & numerical data MH - Surveys and Questionnaires MH - Energy Metabolism MH - Colitis, Ulcerative MH - Micronutrients OTO - NOTNLM OT - IBD OT - Mediterranean diet OT - energy intake OT - nutrition OT - pediatrics EDAT- 2024/08/07 06:42 MHDA- 2024/09/25 22:18 CRDT- 2024/08/07 03:03 PHST- 2024/07/24 00:00 [revised] PHST- 2024/06/13 00:00 [received] PHST- 2024/07/30 00:00 [accepted] PHST- 2024/09/25 22:18 [medline] PHST- 2024/08/07 06:42 [pubmed] PHST- 2024/08/07 03:03 [entrez] AID - 10.1002/jpn3.12344 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2024 Sep;79(3):602-609. doi: 10.1002/jpn3.12344. Epub 2024 Aug 6. PMID- 39106381 OWN - NLM STAT- MEDLINE DCOM- 20240806 LR - 20240806 IS - 0043-5147 (Print) IS - 0043-5147 (Linking) VI - 77 IP - 6 DP - 2024 TI - Substantiation of the methodology for assessing the biological age of adolescents. PG - 1205-1210 LID - 10.36740/WLek202406114 [doi] AB - OBJECTIVE: Aim: To substantiate the methodology for assessing the biological age of adolescent high schoolers (boys and girls). PATIENTS AND METHODS: Materials and Methods: Boys aged 14-15 (n = 102) and girls aged 12-13 (n = 101) were studied. The choice of these age groups is explained by the presence of the most significant individual differences in morphological and functional characteristics in these adolescents. Methods: anthropometry, somatometry, somatoscopy, tonometry, spirometry, dynamometry, Stange's test, Rufier and Robinson indices. The interaction of the results of different methods of assessing biological age was conducted on one sex-age sample using factor analysis (principal components method). RESULTS: Results: It has been established that the biological age of adolescents can be reliably determined using a set of three components: an assessment of the level of physical development, the index of heterochronicity, and the degree of manifestation of secondary sexual characteristics (for boys with a probability of 90.2 %, for girls - 92.1 %). The percentage ratio of these components has sexual peculiarities. Methodologies for assessing biological age for scientific purposes and rapid assessment for use in the practice of physical education and sports have been proposed. The indicators of rapid assessment are body length and the degree of hair development in the axilla. The reliability of the rapid assessment is 81.4 % for boys and 83.2 % for girls. CONCLUSION: Conclusions: Developing adequate physical activities for adolescents of different biological ages will help improve the physical health of the younger generation. FAU - Arefiev, Valery G AU - Arefiev VG AD - UKRAINIAN STATE DRAGOMANOV UNIVERSITY, KYIV, UKRAINE. FAU - Andrieieva, Olena V AU - Andrieieva OV AD - NATIONAL UNIVERSITY OF UKRAINE ON PHYSICAL EDUCATION AND SPORT, KYIV, UKRAINE. FAU - Arkhipov, Oleksandr A AU - Arkhipov OA AD - UKRAINIAN STATE DRAGOMANOV UNIVERSITY, KYIV, UKRAINE. FAU - Mykhailova, Nataliia D AU - Mykhailova ND AD - UKRAINIAN STATE DRAGOMANOV UNIVERSITY, KYIV, UKRAINE. FAU - Liakhova, Inna M AU - Liakhova IM AD - BORYS GRINCHENKO KYIV UNIVERSITY, KYIV, UKRAINE. FAU - Okhrimenko, Ivan capital EM, Cyrillic AU - Okhrimenko Icapital EM, Cyrillic AD - NATIONAL ACADEMY OF INTERNAL AFFAIRS, KYIV, UKRAINE. FAU - Moroz, Lyudmila V AU - Moroz LV AD - SUMY STATE PEDAGOGICAL UNIVERSITY NAMED AFTER A. S. MAKARENKO, SUMY, UKRAINE. LA - eng PT - Journal Article PL - Poland TA - Wiad Lek JT - Wiadomosci lekarskie (Warsaw, Poland : 1960) JID - 9705467 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - *Anthropometry/methods MH - Child MH - Adolescent Development OTO - NOTNLM OT - biological age OT - adolescents OT - methodology OT - rapid assessment EDAT- 2024/08/06 18:42 MHDA- 2024/08/06 18:43 CRDT- 2024/08/06 15:43 PHST- 2024/08/06 18:43 [medline] PHST- 2024/08/06 18:42 [pubmed] PHST- 2024/08/06 15:43 [entrez] AID - 10.36740/WLek202406114 [doi] PST - ppublish SO - Wiad Lek. 2024;77(6):1205-1210. doi: 10.36740/WLek202406114. PMID- 39104637 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260923 IS - 2690-442X (Electronic) IS - 2690-442X (Linking) VI - 4 IP - 4 DP - 2024 Aug TI - Association of frequent intake of trans fatty acids and saturated fatty acids in diets with increased susceptibility of atopic dermatitis exacerbation in young Chinese adults: A cross-sectional study in Singapore/Malaysia. PG - e330 LID - 10.1002/ski2.330 [doi] LID - e330 AB - BACKGROUND & OBJECTIVE: Numerous evidence has attributed diets with a high fatty acids (FAs) intake to be associated with atopic dermatitis (AD) development. Therefore, this study investigated the association between intake frequencies of five dietary FAs and AD exacerbations among young Chinese adults from Singapore and Malaysia. METHODS: A validated International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was investigator-administered to 13,561 subjects to collect information on socioeconomic, anthropometric, dietary and lifestyles habits, and personal/family medical histories. Six novel dietary indices were derived to analyse the associations between total FAs, trans fatty acids (TFAs), saturated fatty acids (SFAs), monounsaturated fatty acids, linoleic acids, and alpha-linolenic acids in diets and AD exacerbation. Synergy factor (SF) analysis was used to identify interactions between the dietary FAs to influence disease susceptibility. RESULTS: In our multivariable model adjusted for age, gender, BMI, parental eczema, and lifestyle factors, a diet high in total estimated FAs was strongly associated with AD (Adjusted Odds Ratio (AOR): 1.227; 95% Confidence Interval (CI): 1.054-1.429; adjusted p-value <0.01). Particularly, high estimated total TFAs and SFAs were significantly associated with AD exacerbations including chronic and current moderate-to-severe AD. The association between TFAs and AD remained strong even controlled for the total FAs in diets and false discovery rate corrected (AOR: 1.516; 95% CI: 1.094-2.097; adjusted p-value <0.05). Similarly, having a high SFAs in diets was associated with AD (AOR: 1.581; 95% CI: 1.106-2.256; adjusted p-value <0.05) independently on the total FAs in diets. FAs in diets do not interact to influence AD. CONCLUSION: Overall, these results highlighted an association between high dietary TFAs and SFAs and AD exacerbations in an Asian population. CI - (c) 2024 The Authors. Skin Health and Disease published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists. FAU - Lim, Jun Jie AU - Lim JJ AUID- ORCID: 0000-0001-5485-1749 AD - Department of Biological Sciences Faculty of Science National University of Singapore Singapore Singapore. FAU - Lim, Sing Wei AU - Lim SW AD - Department of Biological Sciences Faculty of Science National University of Singapore Singapore Singapore. FAU - Reginald, Kavita AU - Reginald K AUID- ORCID: 0000-0003-1530-5934 AD - Department of Biological Sciences Faculty of Science National University of Singapore Singapore Singapore. AD - Department of Biological Sciences School of Medicine and Life Sciences Sunway University Petaling Jaya Malaysia. FAU - Say, Yee-How AU - Say YH AUID- ORCID: 0000-0003-2363-5239 AD - Department of Biological Sciences Faculty of Science National University of Singapore Singapore Singapore. AD - Department of Biological Sciences School of Medicine and Life Sciences Sunway University Petaling Jaya Malaysia. AD - Department of Biomedical Science Faculty of Science Universiti Tunku Abdul Rahman (UTAR) Kampar Malaysia. FAU - Liu, Mei Hui AU - Liu MH AUID- ORCID: 0000-0001-7405-7008 AD - Department of Food Science & Technology Faculty of Science National University of Singapore Singapore Singapore. FAU - Chew, Fook Tim AU - Chew FT AUID- ORCID: 0000-0003-1337-5146 AD - Department of Biological Sciences Faculty of Science National University of Singapore Singapore Singapore. LA - eng PT - Journal Article DEP - 20240626 PL - England TA - Skin Health Dis JT - Skin health and disease JID - 9918227353706676 PMC - PMC11297457 COIS- F.T.C. reports grants from National University of Singapore, Singapore Ministry of Education Academic Research Fund, Singapore Immunology Network, National Medical Research Council (NMRC) (Singapore), Biomedical Research Council (BMRC) (Singapore), National Research Foundation (NRF) (Singapore), Singapore Food Agency (SFA), and the Agency for Science Technology and Research (A*STAR) (Singapore), during the conduct of the study; and consultancy fees from Sime Darby Technology Centre; First Resources Ltd; Genting Plantation, Olam International, and Syngenta Crop Protection, outside the submitted work. EDAT- 2024/08/06 06:43 MHDA- 2024/08/06 06:44 PMCR- 2024/06/26 CRDT- 2024/08/06 04:17 PHST- 2023/05/03 00:00 [received] PHST- 2023/11/17 00:00 [revised] PHST- 2023/12/24 00:00 [accepted] PHST- 2024/08/06 06:44 [medline] PHST- 2024/08/06 06:43 [pubmed] PHST- 2024/08/06 04:17 [entrez] PHST- 2024/06/26 00:00 [pmc-release] AID - SKI2330 [pii] AID - 10.1002/ski2.330 [doi] PST - epublish SO - Skin Health Dis. 2024 Jun 26;4(4):e330. doi: 10.1002/ski2.330. eCollection 2024 Aug. PMID- 39103376 OWN - NLM STAT- MEDLINE DCOM- 20240805 LR - 20240812 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Aug 5 TI - The intersection of physical activity type and gender in patterns of disordered eating. PG - 18127 LID - 10.1038/s41598-024-68657-4 [doi] LID - 18127 AB - Although previous research has linked disordered eating to physical activity involvement, more recent studies suggest that sports participation may be protective against disordered eating; however, due to inconsistent findings on how physical activity affects disordered eating and limited research comparing types of physical activity across weight control behaviours, our aim was to validate physical activity categorization across disordered eating components in both men and women. In this online study, 209 men and 539 women completed questionnaires assessing various components of disordered eating and overall physical activity participation. Pearson correlation coefficients, independent samples t-tests, multiple response crosstabulations, and linear regressions were calculated to achieve the aims of this study. Participation in various types of physical activity significantly predicted various components of disordered eating attitudes, behaviours, and cognitions. Specifically, for women, purging and restricting eating were associated with participation in ball games, while a focus on muscle building was associated with both ball games and weight-class physical activity. For men, body dissatisfaction and excessive exercise were associated with weight-class physical activity participation, while cognitive restraint and muscle building were related to aesthetic sports participation. Purging was associated with both aesthetic and weight-class physical activity, whereas restricting eating was related to weight-class physical activity and ball games. These inconsistencies underscore the need for further research to fully elucidate the relationship between participation in different types of physical activity and the various components of disordered eating. CI - (c) 2024. The Author(s). FAU - Beaulieu, Danie A AU - Beaulieu DA AD - Department of Psychology, University of New Brunswick, 100 Tucker Park Road, Saint John, NB, E2L 4L5, Canada. FAU - Best, Lisa A AU - Best LA AUID- ORCID: 0000-0002-4596-9814 AD - Department of Psychology, University of New Brunswick, 100 Tucker Park Road, Saint John, NB, E2L 4L5, Canada. lbest@unb.ca. LA - eng PT - Journal Article DEP - 20240805 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Feeding and Eating Disorders/psychology/epidemiology MH - Female MH - Male MH - *Exercise/physiology MH - Adult MH - Surveys and Questionnaires MH - Young Adult MH - Adolescent MH - Sex Factors MH - Feeding Behavior/psychology/physiology MH - Middle Aged MH - Body Image/psychology MH - Sports/psychology PMC - PMC11300868 COIS- The authors declare no competing interests. EDAT- 2024/08/06 00:41 MHDA- 2024/08/06 00:42 PMCR- 2024/08/05 CRDT- 2024/08/05 23:17 PHST- 2024/02/23 00:00 [received] PHST- 2024/07/25 00:00 [accepted] PHST- 2024/08/06 00:42 [medline] PHST- 2024/08/06 00:41 [pubmed] PHST- 2024/08/05 23:17 [entrez] PHST- 2024/08/05 00:00 [pmc-release] AID - 10.1038/s41598-024-68657-4 [pii] AID - 68657 [pii] AID - 10.1038/s41598-024-68657-4 [doi] PST - epublish SO - Sci Rep. 2024 Aug 5;14(1):18127. doi: 10.1038/s41598-024-68657-4. PMID- 39101915 OWN - NLM STAT- MEDLINE DCOM- 20241028 LR - 20251102 IS - 1939-134X (Electronic) IS - 1040-3590 (Print) IS - 1040-3590 (Linking) VI - 36 IP - 11 DP - 2024 Nov TI - Development of the Food Addiction Symptom Inventory: The first clinical interview to assess ultra-processed food addiction. PG - 654-664 LID - 10.1037/pas0001340 [doi] AB - Prior research on ultra-processed food addiction (FA) has utilized the self-report Yale Food Addiction Scale (YFAS) measures to identify individuals who experience indicators of substance-use disorders with respect to their consumption of ultra-processed foods. Studies using the YFAS have provided insight into the clinical utility of FA as both a distinct construct and an indicator of more severe psychopathology among individuals with eating disorders. However, the absence of clinician-administered assessment tools for FA has been identified as a barrier to the evaluation of FA as a novel clinical syndrome. Thus, the present study reflects the development of the Food Addiction Symptom Inventory (FASI), a clinician-administered assessment of FA, adapted from the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, fifth editon modules for diagnosing substance-use disorders. The psychometric properties of the FASI and its concordance with the YFAS 2.0 were evaluated in a cross-sectional study of adults (n = 53) with binge-type eating disorders. The FASI performed appropriately on indices of reliability and validity. Concordance between the FASI and YFAS 2.0 was established for the symptom scores (r = .53, p < .001), and > 70% agreement was achieved for FA categorization. Using the FASI, 80% of individuals with bulimia nervosa and 91.7% of those with binge eating disorder were identified as exhibiting FA. While the YFAS 2.0 and FASI both lead to similar assessments of FA symptoms, the FASI provides an essential approach for clinician-guided identification of this phenotype, which may be particularly important when participants have high levels of dietary restraint or limited insight into the impact of their eating behavior. (PsycInfo Database Record (c) 2024 APA, all rights reserved). FAU - LaFata, Erica M AU - LaFata EM AUID- ORCID: 0000-0002-8505-6366 AD - Center for Weight, Eating, and Lifestyle Science, Drexel University. FAU - Worwag, Kate AU - Worwag K AD - Center for Weight, Eating, and Lifestyle Science, Drexel University. FAU - Derrigo, Karly AU - Derrigo K AD - Department of Psychology, Virginia Commonwealth University. FAU - Hessler, Chloe AU - Hessler C AUID- ORCID: 0009-0001-9046-2967 AD - Center for Weight, Eating, and Lifestyle Science, Drexel University. FAU - Allison, Kelly C AU - Allison KC AUID- ORCID: 0000-0002-9807-0220 AD - Department of Psychiatry, Center for Weight and Eating Disorders, Perelman School of Medicine, University of Pennsylvania. FAU - Juarascio, Adrienne S AU - Juarascio AS AUID- ORCID: 0000-0001-6377-4212 AD - Center for Weight, Eating, and Lifestyle Science, Drexel University. FAU - Gearhardt, Ashley N AU - Gearhardt AN AUID- ORCID: 0000-0003-3843-5731 AD - Department of Psychology, University of Michigan. LA - eng SI - ClinicalTrials.gov/NCT04661410 GR - R01 MH122392/MH/NIMH NIH HHS/United States PT - Journal Article DEP - 20240805 PL - United States TA - Psychol Assess JT - Psychological assessment JID - 8915253 SB - IM MH - Humans MH - *Food Addiction/diagnosis/psychology MH - Female MH - Adult MH - Male MH - *Psychometrics MH - Reproducibility of Results MH - Cross-Sectional Studies MH - Young Adult MH - Psychiatric Status Rating Scales MH - Middle Aged MH - Binge-Eating Disorder/diagnosis/psychology MH - Interview, Psychological MH - Fast Foods MH - Adolescent MH - Food, Processed PMC - PMC11874137 MID - NIHMS2055871 EDAT- 2024/08/05 12:43 MHDA- 2024/10/28 18:23 PMCR- 2025/11/01 CRDT- 2024/08/05 10:43 PHST- 2024/10/28 18:23 [medline] PHST- 2024/08/05 12:43 [pubmed] PHST- 2024/08/05 10:43 [entrez] PHST- 2025/11/01 00:00 [pmc-release] AID - 2025-10638-001 [pii] AID - 10.1037/pas0001340 [doi] PST - ppublish SO - Psychol Assess. 2024 Nov;36(11):654-664. doi: 10.1037/pas0001340. Epub 2024 Aug 5. PMID- 39101608 OWN - NLM STAT- MEDLINE DCOM- 20240822 LR - 20240827 IS - 1552-3365 (Electronic) IS - 0363-5465 (Print) IS - 0363-5465 (Linking) VI - 52 IP - 10 DP - 2024 Aug TI - The Association Between the Development of Cam Morphology During Skeletal Growth in High-Impact Athletes and the Presence of Cartilage Loss and Labral Damage in Adulthood: A Prospective Cohort Study With a 12-Year Follow-up. PG - 2555-2564 LID - 10.1177/03635465241256123 [doi] AB - BACKGROUND: Cam morphology develops during skeletal growth, but its influence on cartilage and the labrum in high-impact athletes later in life is unknown. PURPOSE: To (1) explore the association between the presence and duration of cam morphology during adolescence and the cartilage and labral status 7 to 12 years later and (2) report the prevalence of cartilage loss and labral damage in a population of young male athletes (<32 years old) who played professional soccer during skeletal growth. STUDY DESIGN: Cohort study (Prognosis); Level of evidence, 2. METHODS: A total of 89 healthy male academy soccer players from the Dutch soccer club Feyenoord (aged 12-19 years) were included at baseline. At baseline and 2.5- and 5-year follow-ups, standardized supine anteroposterior pelvis and frog-leg lateral radiographs of each hip were obtained. At 12-year follow-up, magnetic resonance imaging of both hips was performed. Cam morphology was defined by a validated alpha angle >/=60 degrees on radiographs at baseline or 2.5- or 5-year follow-up when the growth plates were closed. Hips with the presence of cam morphology at baseline or at 2.5-year follow-up were classified as having a "longer duration" of cam morphology. Hips with cam morphology only present since 5-year follow-up were classified as having a "shorter duration" of cam morphology. At 12-year follow-up, cartilage loss and labral abnormalities were assessed semiquantitatively. Associations were estimated using logistic regression, adjusted for age and body mass index. RESULTS: Overall, 35 patients (70 hips) with a mean age of 28.0 +/- 2.0 years and mean body mass index of 24.1 +/- 1.8 participated at 12-year follow-up. Cam morphology was present in 56 of 70 hips (80%). The prevalence of cartilage loss was 52% in hips with cam morphology and 21% in hips without cam morphology (adjusted odds ratio, 4.52 [95% CI, 1.16-17.61]; P = .03). A labral abnormality was present in 77% of hips with cam morphology and in 64% of hips without cam morphology (adjusted odds ratio, 1.99 [95% CI, 0.59-6.73]; P = .27). The duration of cam morphology did not influence these associations. CONCLUSION: The development of cam morphology during skeletal growth was associated with future magnetic resonance imaging findings consistent with cartilage loss in young adults but not with labral abnormalities. FAU - Claes, Paula A M AU - Claes PAM AD - Department of Orthopaedics and Sports Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands. FAU - Hanff, David F AU - Hanff DF AD - Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands. FAU - Weir, Adam AU - Weir A AD - Department of Orthopaedics and Sports Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands. AD - Sports Groin Pain Centre, Aspetar Orthopaedic and Sports Medicine Hospital, Doha, Qatar. FAU - Riedstra, Noortje S AU - Riedstra NS AD - Department of Orthopaedics and Sports Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands. FAU - Weinans, Harrie AU - Weinans H AD - Department of Orthopaedics, University Medical Center Utrecht, Utrecht, the Netherlands. FAU - Eygendaal, Denise AU - Eygendaal D AD - Department of Orthopaedics and Sports Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands. FAU - Heerey, Josh AU - Heerey J AD - La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Victoria, Australia. FAU - Oei, Edwin H G AU - Oei EHG AD - Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands. FAU - van Klij, Pim AU - van Klij P AD - Department of Sports Medicine, Isala Clinics, Zwolle, the Netherlands. FAU - Agricola, Rintje AU - Agricola R AD - Department of Orthopaedics and Sports Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands. LA - eng PT - Journal Article DEP - 20240805 PL - United States TA - Am J Sports Med JT - The American journal of sports medicine JID - 7609541 SB - IM MH - Humans MH - Male MH - Adolescent MH - Prospective Studies MH - Young Adult MH - Follow-Up Studies MH - *Soccer/injuries MH - *Cartilage, Articular/diagnostic imaging/growth & development/pathology MH - Child MH - Magnetic Resonance Imaging MH - Adult MH - Bone Development MH - Radiography MH - Athletes MH - Femoracetabular Impingement/diagnostic imaging MH - Hip Joint/diagnostic imaging/growth & development PMC - PMC11344970 OTO - NOTNLM OT - femoroacetabular impingement OT - hip OT - osteoarthritis OT - soccer COIS- One or more of the authors has declared the following potential conflict of interest or source of funding: The Anna Foundation (Anna Fonds) and the Dutch Orthopaedic Research and Education Foundation provided financial support for this study. D.E. has received a personal educational grant (euro2200) from Zimmer Biomet. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto. EDAT- 2024/08/05 12:43 MHDA- 2024/08/22 12:42 PMCR- 2024/08/25 CRDT- 2024/08/05 08:13 PHST- 2024/08/22 12:42 [medline] PHST- 2024/08/05 12:43 [pubmed] PHST- 2024/08/05 08:13 [entrez] PHST- 2024/08/25 00:00 [pmc-release] AID - 10.1177_03635465241256123 [pii] AID - 10.1177/03635465241256123 [doi] PST - ppublish SO - Am J Sports Med. 2024 Aug;52(10):2555-2564. doi: 10.1177/03635465241256123. Epub 2024 Aug 5. PMID- 39099219 OWN - NLM STAT- MEDLINE DCOM- 20240805 LR - 20241223 IS - 1877-8879 (Electronic) IS - 1877-8860 (Linking) VI - 24 IP - 1 DP - 2024 Jan 1 TI - Translation and examination of construct validity of the Danish version of the Tampa Scale for Kinesiophobia. LID - 10.1515/sjpain-2024-0022 [doi] AB - OBJECTIVES: This study investigates the construct validity of the Danish Tampa Scale for Kinesiophobia (TSK). METHODS: The English 17-item scale was translated into Danish adhering to WHO's guidelines. The construct validity of the TSK was examined in a random general population sample of 4,884 18- to 72-year olds with pain within the past 4 weeks. Examination of construct validity adhered to the COSMIN checklist. Structural validity was examined by splitting the sample and conducting exploratory factor analysis on one half and confirmatory factor analysis on the other half. Convergent validity was examined through associations with self-report measures and objective physical performance tests. Reference scores for the TSK were calculated. RESULTS: After translation, all respondents felt confident that they understood the meaning of the items. All but one found the questionnaire acceptable. The exploratory factor analysis suggested that a 1-factor 13-item version without 4 reversed items resulted in the most consistent fit across subgroups of gender, age, and severe pain report. Five different models of the TSK were tested in the confirmatory factor analysis. While none were excellent fits, both one- and two-factor models of the TSK-13 and TSK-11 were acceptable. Two-factor models marginally outperformed one-factor models on goodness of fit. There was no association between TSK scores and muscular fitness or self-reported physical activity. Cardiorespiratory fitness, self-perceived physical fitness, and self-efficacy had weak correlations with TSK scores. Scores showed modest associations with self-report measures of anxiety, illness worry, pain interference, and daily limitations. CONCLUSIONS: Based on an overall consideration of results, we recommend using the TSK-13 as a one-dimensional construct for both research and clinical purposes pending further examinations of the TSK in clinical samples. TSK scores from the present study can serve as a standard of reference for levels of Kinesiophobia in the general population. CI - (c) 2024 the author(s), published by De Gruyter. FAU - Pedersen, Majbritt Mostrup AU - Pedersen MM AD - The Research Clinic for Functional Disorders, Aarhus University Hospital, Palle Juul Jensens Boulevard 11, 8200, Aarhus N, Denmark. FAU - Carstensen, Tina Birgitte Wisbech AU - Carstensen TBW AD - The Research Clinic for Functional Disorders, Aarhus University Hospital, Palle Juul Jensens Boulevard 11, 8200, Aarhus N, Denmark. AD - Institute of Clinical Medicine, Aarhus University, Aarhus N, Denmark. FAU - Ornbol, Eva AU - Ornbol E AD - The Research Clinic for Functional Disorders, Aarhus University Hospital, Palle Juul Jensens Boulevard 11, 8200, Aarhus N, Denmark. AD - Institute of Clinical Medicine, Aarhus University, Aarhus N, Denmark. FAU - Fink, Per AU - Fink P AD - The Research Clinic for Functional Disorders, Aarhus University Hospital, Palle Juul Jensens Boulevard 11, 8200, Aarhus N, Denmark. AD - Institute of Clinical Medicine, Aarhus University, Aarhus N, Denmark. FAU - Jorgensen, Torben AU - Jorgensen T AD - Centre for Clinical Research and Prevention, Bispebjerg/Frederiksberg Hospital, Capital Region, Copenhagen, Denmark. AD - Department of Public Health, Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark. AD - Faculty of Medicine, Aalborg University, Aalborg, Denmark. FAU - Dantoft, Thomas Meinertz AU - Dantoft TM AD - Centre for Clinical Research and Prevention, Bispebjerg/Frederiksberg Hospital, Capital Region, Copenhagen, Denmark. FAU - Frostholm, Lisbeth AU - Frostholm L AD - The Research Clinic for Functional Disorders, Aarhus University Hospital, Palle Juul Jensens Boulevard 11, 8200, Aarhus N, Denmark. AD - Institute of Clinical Medicine, Aarhus University, Aarhus N, Denmark. LA - eng GR - R155-2013-14070/The Lundbeck Foundation/ GR - 7-11-0213/The Tryg Foundation/ GR - R144-A4180/Danish Rheumatism Association/ GR - 6187/The Jascha Foundation/ PT - Journal Article PT - Validation Study DEP - 20240805 PL - Germany TA - Scand J Pain JT - Scandinavian journal of pain JID - 101520867 SB - IM MH - Humans MH - Male MH - Female MH - Denmark MH - *Phobic Disorders/psychology/diagnosis MH - Middle Aged MH - Adult MH - Aged MH - Reproducibility of Results MH - Adolescent MH - Young Adult MH - Surveys and Questionnaires/standards MH - Translations MH - Psychometrics MH - Factor Analysis, Statistical MH - Kinesiophobia OTO - NOTNLM OT - Tampa Scale of Kinesiophobia OT - construct validity OT - translation OT - validation EDAT- 2024/08/05 06:43 MHDA- 2024/08/05 06:44 CRDT- 2024/08/05 02:32 PHST- 2024/03/11 00:00 [received] PHST- 2024/06/26 00:00 [accepted] PHST- 2024/08/05 06:44 [medline] PHST- 2024/08/05 06:43 [pubmed] PHST- 2024/08/05 02:32 [entrez] AID - sjpain-2024-0022 [pii] AID - 10.1515/sjpain-2024-0022 [doi] PST - epublish SO - Scand J Pain. 2024 Aug 5;24(1). doi: 10.1515/sjpain-2024-0022. eCollection 2024 Jan 1. PMID- 39097657 OWN - NLM STAT- MEDLINE DCOM- 20240803 LR - 20260307 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Aug 3 TI - Passively sensing smartphone use in teens with rates of use by sex and across operating systems. PG - 17982 LID - 10.1038/s41598-024-68467-8 [doi] LID - 17982 AB - Youth screen media activity is a growing concern, though few studies include objective usage data. Through the longitudinal, U.S.-based Adolescent Brain Cognitive Development (ABCD) Study, youth (m(age) = 14; n = 1415) self-reported their typical smartphone use and passively recorded three weeks of smartphone use via the ABCD-specific Effortless Assessment Research System (EARS) application. Here we describe and validate passively-sensed smartphone keyboard and app use measures, provide code to harmonize measures across operating systems, and describe trends in adolescent smartphone use. Keyboard and app-use measures were reliable and positively correlated with one another (r = 0.33) and with self-reported use (rs = 0.21-0.35). Participants recorded a mean of 5 h of daily smartphone use, which is two more hours than they self-reported. Further, females logged more smartphone use than males. Smartphone use was recorded at all hours, peaking on average from 8 to 10 PM and lowest from 3 to 5 AM. Social media and texting apps comprised nearly half of all use. Data are openly available to approved investigators ( https://nda.nih.gov/abcd/ ). Information herein can inform use of the ABCD dataset to longitudinally study health and neurodevelopmental correlates of adolescent smartphone use. CI - (c) 2024. The Author(s). FAU - Alexander, Jordan D AU - Alexander JD AD - University of Minnesota, Minneapolis, USA. FAU - Linkersdorfer, Janosch AU - Linkersdorfer J AD - Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, MC 0405, La Jolla, CA, 92093, USA. FAU - Toda-Thorne, Katherine AU - Toda-Thorne K AD - University of Michigan, Ann Arbor, USA. FAU - Sullivan, Ryan M AU - Sullivan RM AD - University of Wisconsin-Milwaukee, Milwaukee, USA. FAU - Cummins, Kevin M AU - Cummins KM AD - California State University, Fullerton, USA. FAU - Tomko, Rachel L AU - Tomko RL AD - Medical University of South Carolina, Charleston, USA. FAU - Allen, Nicholas B AU - Allen NB AD - University of Oregon, Eugene, USA. FAU - Bagot, Kara S AU - Bagot KS AD - University of California, Los Angeles, Los Angeles, USA. FAU - Baker, Fiona C AU - Baker FC AD - SRI International, Menlo Park, USA. FAU - Fuemmeler, Bernard F AU - Fuemmeler BF AD - Virginia Commonwealth University, Richmond, USA. FAU - Hoffman, Elizabeth A AU - Hoffman EA AD - The National Institute on Drug Abuse, North Bethesda, USA. FAU - Kiss, Orsolya AU - Kiss O AD - SRI International, Menlo Park, USA. FAU - Mason, Michael J AU - Mason MJ AD - University of Tennessee, Knoxville, USA. FAU - Nguyen-Louie, Tam T AU - Nguyen-Louie TT AD - Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, MC 0405, La Jolla, CA, 92093, USA. FAU - Tapert, Susan F AU - Tapert SF AD - Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, MC 0405, La Jolla, CA, 92093, USA. FAU - Smith, Calen J AU - Smith CJ AD - Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, MC 0405, La Jolla, CA, 92093, USA. FAU - Squeglia, Lindsay M AU - Squeglia LM AD - Medical University of South Carolina, Charleston, USA. FAU - Wade, Natasha E AU - Wade NE AD - Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, MC 0405, La Jolla, CA, 92093, USA. nwade@health.ucsd.edu. LA - eng GR - U24 DA041147/DA/NIDA NIH HHS/United States GR - U01 DA051039/DA/NIDA NIH HHS/United States GR - U01 DA041120/DA/NIDA NIH HHS/United States GR - K08 DA050779/DA/NIDA NIH HHS/United States GR - U01 DA051018/DA/NIDA NIH HHS/United States GR - U01 DA041093/DA/NIDA NIH HHS/United States GR - U24 DA041123/DA/NIDA NIH HHS/United States GR - U01 DA051038/DA/NIDA NIH HHS/United States GR - U01 DA051037/DA/NIDA NIH HHS/United States GR - U01 DA051016/DA/NIDA NIH HHS/United States GR - U01 DA041117/DA/NIDA NIH HHS/United States GR - U01 DA041148/DA/NIDA NIH HHS/United States GR - T32 DA050560/DA/NIDA NIH HHS/United States GR - U01 DA041174/DA/NIDA NIH HHS/United States GR - U01 DA041134/DA/NIDA NIH HHS/United States GR - U01 DA041022/DA/NIDA NIH HHS/United States GR - U01 DA041156/DA/NIDA NIH HHS/United States GR - U01 DA050987/DA/NIDA NIH HHS/United States GR - U01 DA041025/DA/NIDA NIH HHS/United States GR - U01 DA050989/DA/NIDA NIH HHS/United States GR - U01 DA041089/DA/NIDA NIH HHS/United States GR - U01 DA050988/DA/NIDA NIH HHS/United States GR - U01 DA041106/DA/NIDA NIH HHS/United States GR - R01 DA057567/DA/NIDA NIH HHS/United States GR - U01 DA041028/DA/NIDA NIH HHS/United States GR - U01 DA041048/DA/NIDA NIH HHS/United States PT - Journal Article DEP - 20240803 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Adolescent MH - Female MH - *Smartphone MH - Male MH - Mobile Applications MH - Self Report MH - Adolescent Behavior MH - Longitudinal Studies MH - Social Media MH - Sex Factors PMC - PMC11297944 OTO - NOTNLM OT - Adolescents OT - Android OT - Passive sensing OT - Screen media activity OT - Screen time OT - Smartphone use OT - iOS COIS- N.B. Allen holds an equity interest in Ksana Health, which produces commercial licenses for the EARS software that was used in this manuscript. No other authors have any competing interests to disclose. EDAT- 2024/08/04 13:44 MHDA- 2024/08/04 13:45 PMCR- 2024/08/03 CRDT- 2024/08/03 23:19 PHST- 2024/04/11 00:00 [received] PHST- 2024/07/24 00:00 [accepted] PHST- 2024/08/04 13:45 [medline] PHST- 2024/08/04 13:44 [pubmed] PHST- 2024/08/03 23:19 [entrez] PHST- 2024/08/03 00:00 [pmc-release] AID - 10.1038/s41598-024-68467-8 [pii] AID - 68467 [pii] AID - 10.1038/s41598-024-68467-8 [doi] PST - epublish SO - Sci Rep. 2024 Aug 3;14(1):17982. doi: 10.1038/s41598-024-68467-8. PMID- 39096045 OWN - NLM STAT- MEDLINE DCOM- 20240803 LR - 20260225 IS - 2047-7163 (Electronic) IS - 0036-8504 (Print) IS - 0036-8504 (Linking) VI - 107 IP - 3 DP - 2024 Jul-Sep TI - Agreement of ultra-short-term heart rate variability measure after different repeated bouts of sprint ability tests. PG - 368504241262150 LID - 10.1177/00368504241262150 [doi] LID - 00368504241262150 AB - This study aims to explore: (1) the validity of post-exercise ultra-short-term heart rate variability (HRV(ust)) after two different bouts of repeated sprint ability test (RSA), and (2) the relationship between HRV(ust) measure and RSA performance. Twenty adolescent male futsal players voluntarily participated in this study (age: 17.65 +/- 1.81 years, body height: 170.88 +/- 4.98 cm, body weight: 61.78 +/- 4.67 kg). The participants performed a standard RSA test (RSA(standard)) and an RSA test with a 10% decrement of the best sprint time test (RSA(10%decrement)) on two separate occasions within a week. On both occasions, a 5-min resting electrocardiography was administered pre- and post-RSA exercise protocols. The first 30-s (HRV(ust30s)), 60-s (HRV(ust60s)), and 60-120-s (HRV(ust1-2min)) were extracted and used to compare with the standard of 5-min HRV recording (HRV(criterion)). The natural logarithm (ln) of the standard deviation of normal-to-normal intervals (SDNN) and root mean square of successive normal-to-normal interval differences (RMSSD) HRV indices were utilised to establish intraclass correlation coefficient (ICC(2,1)), coefficient of variation (%CV), and Pearson product-moment correlation (r). Results revealed the ICC values of HRV(ust) lnSDNN (RSA(standard) = 0.77-0.88; RSA(10%decrement) = 0.41-0.71) and lnRMSSD (RSA(standard) = 0.81-0.86; RSA(10%decrement) = 0.57-0.82). Furthermore, significantly positive correlations between best sprint time and post-exercise HRV(ust) indices were found in lnSDNN (r = 0.47-0.62; p < 0.05) and lnRMSSD (r = 0.45; p < 0.05). Additionally, a large CV of lnSDNN (RSA(standard) = 32%-45%; RSA(10%decrement) = 29%-39%), lnRMSSD (RSA(standard) = 50%-66%; RSA(10%decrement) = 48%-52%), and ratio (RSA(standard) = 45%-126%; RSA(10%decrement) = 27%-45%) was found after the RSA protocols. In conclusion, the number of bouts of RSA exercise potentially influences the agreement of post-exercise time-domain HRV(ust) indices to standard HRV measure. FAU - Hung, Chin-Hwai AU - Hung CH AD - Department of Physical Education, Fu Jen Catholic University, New Taipei City. FAU - Lu, Wan-An AU - Lu WA AD - College of LOHAS Industry, Fo-Guang University, Yilan. AD - Tanyu Research Laboratory, Taipei. FAU - Pagaduan, Jeffrey Cayaban AU - Pagaduan JC AD - Tanyu Research Laboratory, Taipei. AD - Faculty of Physical Culture, Institute of Active Lifestyle, Palacky University, Olomouc, Czechia. FAU - Kuo, Cheng-Deng AU - Kuo CD AD - Tanyu Research Laboratory, Taipei. AD - Department of Internal Medicine, Taipei Veterans General Hospital Hsinchu Branch, Hsinchu County. AD - Department of Internal Medicine, Hsiao Chung-Cheng Healthcare Group, New Taipei City. FAU - Chen, Yung-Sheng AU - Chen YS AUID- ORCID: 0000-0002-1013-3822 AD - Tanyu Research Laboratory, Taipei. AD - Department of Exercise and Health Sciences, University of Taipei, Taipei. AD - Exercise and Health Promotion Association, New Taipei City. AD - High Performance Unit, Chinese Taipei Football Association, New Taipei City. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Sci Prog JT - Science progress JID - 0411361 SB - IM MH - Humans MH - *Heart Rate/physiology MH - Male MH - *Running/physiology MH - Adolescent MH - *Exercise Test/methods MH - Electrocardiography MH - Athletic Performance/physiology MH - Exercise/physiology PMC - PMC11298065 OTO - NOTNLM OT - Cardiac-related responses OT - autonomic nervous system OT - exercise recovery OT - parasympathetic activation OT - time-domain measure COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2024/08/03 11:43 MHDA- 2024/08/03 11:44 PMCR- 2024/08/02 CRDT- 2024/08/03 03:03 PHST- 2024/08/03 11:44 [medline] PHST- 2024/08/03 11:43 [pubmed] PHST- 2024/08/03 03:03 [entrez] PHST- 2024/08/02 00:00 [pmc-release] AID - 10.1177_00368504241262150 [pii] AID - 10.1177/00368504241262150 [doi] PST - ppublish SO - Sci Prog. 2024 Jul-Sep;107(3):368504241262150. doi: 10.1177/00368504241262150. PMID- 39095786 OWN - NLM STAT- MEDLINE DCOM- 20240803 LR - 20261016 IS - 1479-5868 (Electronic) IS - 1479-5868 (Linking) VI - 21 IP - 1 DP - 2024 Aug 2 TI - Home environment factors associated with child BMI changes during COVID-19 pandemic. PG - 84 LID - 10.1186/s12966-024-01634-2 [doi] LID - 84 AB - BACKGROUND: The influence of home obesogenic environments, as assessed by the validated Family Nutrition and Physical Activity (FNPA) tool, and child obesity during the COVID pandemic were evaluated using electronic health records in this retrospective cohort study. METHODS: Historical data on BMI and the FNPA screening tool were obtained from annual well-child visits within the Geisinger Health System. The study examined youth ages 2-17 that had a BMI record and an FNPA assessment prior to the pandemic (BMI 3/1/19-2/29/20), 1 BMI record 3 months into the pandemic (6/1/20-12/31/20) and 1 BMI in the second year of the pandemic (1/1/21-12/31/21). Tertiles of obesity risk by FNPA score were examined. Mixed-effects linear regression was used to examine change in BMI slope (kg/m(2) per month) pre-pandemic to pandemic using FNPA summary and subscales scores as predictors and adjusting for confounding factors. RESULTS: The analyses included 6,746 children (males: 51.7%, non-Hispanic white: 86.6%, overweight:14.8%, obesity:10.3%, severe obesity: 3.9%; mean(SD) age: 5.7(2.8) years). The rate of BMI change in BMI was greatest from early pandemic compared to pre-pandemic for children in lowest versus highest tertiles of FNPA summary score (0.079 vs. 0.044 kg/m(2)), FNPA-Eating (0.068 vs. 0.049 kg/m(2)), and FNPA-Activity (0.078 vs. 0.052 kg/m(2)). FNPA summary score was significantly associated with change in BMI from the pre-pandemic to early pandemic period (p = 0.014), but not associated with change in BMI during the later pandemic period. CONCLUSIONS: This study provides additional insight into the changes in the rate of BMI change observed among children and adolescents in the United States during the COVID-19 pandemic. The FNPA provides ample opportunity to continue our exploration of the negative impact of the COVID-19 pandemic on the longitudinal growth patterns among children and adolescents. CI - (c) 2024. The Author(s). FAU - McCabe, Carolyn F AU - McCabe CF AUID- ORCID: 0000-0002-1321-621X AD - Population Health Sciences, Center for Obesity and Metabolic Research, Geisinger, 100 N. Academy Ave, Danville, PA, 17822, USA. AD - Center for Obesity and Metabolic Research, Geisinger, 100 N. Academy Ave, Danville, PA, 17822, USA. FAU - Wood, G Craig AU - Wood GC AD - Center for Obesity and Metabolic Research, Geisinger, 100 N. Academy Ave, Danville, PA, 17822, USA. FAU - Welk, Gregory J AU - Welk GJ AD - Department of Kinesiology, University of Iowa, 235 Forker Building, 534 Wallace Road Ames, Iowa City, IA, 50011-4008, USA. FAU - Cook, Adam AU - Cook A AD - Center for Obesity and Metabolic Research, Geisinger, 100 N. Academy Ave, Danville, PA, 17822, USA. FAU - Franceschelli-Hosterman, Jennifer AU - Franceschelli-Hosterman J AD - Department of Nutrition and Weight Management, Geisinger, 100 N Academy Ave, Danville, PA, 17822, USA. FAU - Bailey-Davis, Lisa AU - Bailey-Davis L AD - Population Health Sciences, Center for Obesity and Metabolic Research, Geisinger, 100 N. Academy Ave, Danville, PA, 17822, USA. ldbaileydavis@geisinger.edu. AD - Center for Obesity and Metabolic Research, Geisinger, 100 N. Academy Ave, Danville, PA, 17822, USA. ldbaileydavis@geisinger.edu. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240802 PL - England TA - Int J Behav Nutr Phys Act JT - The international journal of behavioral nutrition and physical activity JID - 101217089 SB - IM MH - Humans MH - *COVID-19/epidemiology MH - Child MH - *Body Mass Index MH - Female MH - Male MH - *Pediatric Obesity/epidemiology MH - Retrospective Studies MH - Adolescent MH - Child, Preschool MH - *SARS-CoV-2 MH - *Home Environment MH - Exercise MH - Pandemics PMC - PMC11295326 OTO - NOTNLM OT - Childhood overweight OT - Electronic health record OT - Family nutrition and physical activity (FNPA) OT - Pediatric obesity OT - Retrospective study COIS- The authors declare that they have no competing interests in this section. EDAT- 2024/08/03 11:42 MHDA- 2024/08/03 11:43 PMCR- 2024/08/02 CRDT- 2024/08/02 23:38 PHST- 2023/12/22 00:00 [received] PHST- 2024/07/23 00:00 [accepted] PHST- 2024/08/03 11:43 [medline] PHST- 2024/08/03 11:42 [pubmed] PHST- 2024/08/02 23:38 [entrez] PHST- 2024/08/02 00:00 [pmc-release] AID - 10.1186/s12966-024-01634-2 [pii] AID - 1634 [pii] AID - 10.1186/s12966-024-01634-2 [doi] PST - epublish SO - Int J Behav Nutr Phys Act. 2024 Aug 2;21(1):84. doi: 10.1186/s12966-024-01634-2. PMID- 39095778 OWN - NLM STAT- MEDLINE DCOM- 20240803 LR - 20241231 IS - 1479-5868 (Electronic) IS - 1479-5868 (Linking) VI - 21 IP - 1 DP - 2024 Aug 2 TI - Validity and reliability of self-reported methods for assessment of 24-h movement behaviours: a systematic review. PG - 83 LID - 10.1186/s12966-024-01632-4 [doi] LID - 83 AB - BACKGROUND: Time spent in sleep, sedentary behaviour (SB), and physical activity are exhaustive and mutually exclusive parts of a 24-h day that need to be considered in a combination. The aim of this study was to identify validated self-reported tools for assessment of movement behaviours across the whole 24-h day, and to review their attributes and measurement properties. METHODS: The databases PubMed, Scopus, and SPORTDiscus were searched until September 2023. Inclusion criteria were: (i) published in English language, (ii) per-reviewed paper, (iii) assessment of self-reported time spent in sleep, SB, and physical activity, (iv) evaluation of measurement properties of all estimates across the full 24-h day, and (v) inclusion of adolescents, adults, or older adults. The methodological quality of included studies was assessed using the Consensus-based Standards for the selection of health Measurement Instruments checklist. RESULTS: Our search returned 2064 records. After studies selection, we included 16 articles that reported construct validity and/or test-retest reliability of 12 unique self-reported tools - eight questionnaires, three time-use recalls, and one time-use diary. Most tools enable assessment of time spent in sleep, and domain-specific SB and physical activity, and account that sum of behaviours should be 24 h. Validity (and reliability) correlation coefficients for sleep ranged between 0.22 and 0.69 (0.41 and 0.92), for SB between 0.06 and 0.57 (0.33 and 0.91), for light-intensity physical activity between 0.18 and 0.46 (0.55 and 0.94), and for moderate- to vigorous-intensity physical activity between 0.38 and 0.56 (0.59 and 0.94). The quality of included studies being mostly fair-to-good. CONCLUSIONS: This review found that only a limited number of validated self-reported tools for assessment of 24-h movement behaviours are currently available. Validity and reliability of most tools are generally adequate to be used in epidemiological studies and population surveillance, while little is known about adequacy for individual level assessments and responsiveness to behavioural change. To further support research, policy, and practice, there is a need to develop new tools that resonate with the emerging 24-h movement paradigm and to evaluate measurement properties by using compositional data analysis. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42022330868. CI - (c) 2024. The Author(s). FAU - Suc, Anja AU - Suc A AD - Faculty of Health Sciences, University of Primorska, Izola, Slovenia. FAU - Einfalt, Lea AU - Einfalt L AD - Faculty of Health Sciences, University of Primorska, Izola, Slovenia. FAU - Sarabon, Nejc AU - Sarabon N AD - Faculty of Health Sciences, University of Primorska, Izola, Slovenia. AD - InnoRenew CoE, Izola, Slovenia. FAU - Kastelic, Kaja AU - Kastelic K AD - InnoRenew CoE, Izola, Slovenia. kaja.kastelic@iam.upr.si. AD - Andrej Marusic Institute, University of Primorska, Koper, Slovenia. kaja.kastelic@iam.upr.si. LA - eng GR - V3-2305/Slovenian Research and Innovation Agency/ GR - V3-2305/Ministry of Health from Republic of Slovenia/ PT - Journal Article PT - Systematic Review DEP - 20240802 PL - England TA - Int J Behav Nutr Phys Act JT - The international journal of behavioral nutrition and physical activity JID - 101217089 SB - IM MH - Humans MH - *Exercise MH - Health Behavior MH - Reproducibility of Results MH - *Sedentary Behavior MH - *Self Report MH - *Sleep MH - Surveys and Questionnaires PMC - PMC11295502 OTO - NOTNLM OT - Measurement OT - Physical activity OT - Physical behaviours OT - Sedentary behaviour OT - Sleep OT - Time-use diary OT - Time-use epidemiology OT - Time-use questionnaire OT - Time-use recall COIS- The authors declare that they have no competing interests. EDAT- 2024/08/03 11:41 MHDA- 2024/08/03 11:42 PMCR- 2024/08/02 CRDT- 2024/08/02 23:38 PHST- 2024/03/21 00:00 [received] PHST- 2024/07/23 00:00 [accepted] PHST- 2024/08/03 11:42 [medline] PHST- 2024/08/03 11:41 [pubmed] PHST- 2024/08/02 23:38 [entrez] PHST- 2024/08/02 00:00 [pmc-release] AID - 10.1186/s12966-024-01632-4 [pii] AID - 1632 [pii] AID - 10.1186/s12966-024-01632-4 [doi] PST - epublish SO - Int J Behav Nutr Phys Act. 2024 Aug 2;21(1):83. doi: 10.1186/s12966-024-01632-4. PMID- 39095010 OWN - NLM STAT- MEDLINE DCOM- 20241110 LR - 20260402 IS - 1097-6833 (Electronic) IS - 0022-3476 (Print) IS - 0022-3476 (Linking) VI - 275 DP - 2024 Dec TI - Validation of Variables for Use in Pediatric Obesity Risk Score Development in Demographically and Racially Diverse United States Cohorts. PG - 114219 LID - S0022-3476(24)00322-6 [pii] LID - 10.1016/j.jpeds.2024.114219 [doi] AB - OBJECTIVE: To evaluate the performance of childhood obesity prediction models in four independent cohorts in the United States, using previously validated variables obtained easily from medical records as measured in different clinical settings. STUDY DESIGN: Data from four prospective cohorts, Latinx, Eating, and Diabetes; Stress in Pregnancy Study; Project Viva; and Center for the Health Assessment of Mothers and Children of Salinas were used to test childhood obesity risk models and predict childhood obesity by ages 4 through 6, using five clinical variables (maternal age, maternal prepregnancy body mass index, birth weight Z-score, weight-for-age Z-score change, and breastfeeding), derived from a previously validated risk model and as measured in each cohort's clinical setting. Multivariable logistic regression was performed within each cohort, and performance of each model was assessed based on discrimination and predictive accuracy. RESULTS: The risk models performed well across all four cohorts, achieving excellent discrimination. The area under the receiver operator curve was 0.79 for Center for the Health Assessment of Mothers and Children of Salinas and Project Viva, 0.83 for Stress in Pregnancy Study, and 0.86 for Latinx, Eating, and Diabetes. At a 50th percentile threshold, the sensitivity of the models ranged from 12% to 53%, and specificity was >/= 90%. The negative predictive values were >/= 80% for all cohorts, and the positive predictive values ranged from 62% to 86%. CONCLUSION: All four risk models performed well in each independent and demographically diverse cohort, demonstrating the utility of these five variables for identifying children at high risk for developing early childhood obesity in the United States. CI - Copyright (c) 2024 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Funatake, Castle J AU - Funatake CJ AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of California, San Francisco, San Francisco, CA. FAU - Armendariz, Marcos AU - Armendariz M AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of California, San Francisco, San Francisco, CA. FAU - Rauch, Stephen AU - Rauch S AD - Center for Environmental Research and Children's Health, University of California, Berkeley, Berkeley, CA. FAU - Eskenazi, Brenda AU - Eskenazi B AD - Center for Environmental Research and Children's Health, University of California, Berkeley, Berkeley, CA. FAU - Nomura, Yoko AU - Nomura Y AD - Department of Psychology, Queens College and Graduate Center, the City University of New York (CUNY), New York, NY; Icahn School of Medicine at Mount Sinai, Department of Psychiatry, New York, NY. FAU - Hivert, Marie-France AU - Hivert MF AD - Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA. FAU - Rifas-Shiman, Sheryl AU - Rifas-Shiman S AD - Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA. FAU - Oken, Emily AU - Oken E AD - Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA. FAU - Shiboski, Stephen C AU - Shiboski SC AD - Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA. FAU - Wojcicki, Janet M AU - Wojcicki JM AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of California, San Francisco, San Francisco, CA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA. Electronic address: Janet.Wojcicki@ucsf.edu. LA - eng GR - R24 ES028529/ES/NIEHS NIH HHS/United States GR - UH3 OD023286/OD/NIH HHS/United States GR - U24 ES028529/ES/NIEHS NIH HHS/United States GR - P01 ES009605/ES/NIEHS NIH HHS/United States GR - R01 HD034568/HD/NICHD NIH HHS/United States GR - R01 DA057310/DA/NIDA NIH HHS/United States GR - R24 ES030894/ES/NIEHS NIH HHS/United States GR - K01 DK080825/DK/NIDDK NIH HHS/United States GR - R01 GM097458/GM/NIGMS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20240731 PL - United States TA - J Pediatr JT - The Journal of pediatrics JID - 0375410 SB - IM MH - Humans MH - Female MH - United States/epidemiology MH - Child, Preschool MH - *Pediatric Obesity/epidemiology/ethnology MH - Child MH - Male MH - Risk Assessment/methods MH - Prospective Studies MH - Body Mass Index MH - Cohort Studies MH - Risk Factors MH - Pregnancy MH - Adult MH - Birth Weight PMC - PMC12700563 MID - NIHMS2122091 OTO - NOTNLM OT - early childhood obesity OT - risk model COIS- Declaration of Competing Interest The authors declare no conflicts of interest. Project Viva was funded by grants RO1HD034568, UH3OD023286, and R24ES030894 from the National Institutes of Health, United States to Dr. Oken. SIPS was supported by grants R01MH1316328 and R01DA057310 from the National Institutes of Health, United States to Dr. Nomura. CHAMACOS was funded by grants R82670901 and RD83171 from the Environmental Protection Agency, United States and PO1ES009605, PO1ES00960, U24ES028529, and R24ES028529 from the National Institutes of Health, United States to Dr. Eskenazi. LEAD was supported by grants NIDDK 080825 and NIDDK 097458 from the National Institutes of Health, United States, as well as the Hellman Family Foundation, United States, Allen Foundation, United States, and Marc and Lynn Benioff to Dr. Wojcicki. The funders had no role in the study design, the collection, analysis, and interpretation of the data, the writing of the report, or the decision to submit for publication. EDAT- 2024/08/03 10:41 MHDA- 2024/11/13 13:52 PMCR- 2025/12/12 CRDT- 2024/08/02 19:24 PHST- 2024/02/26 00:00 [received] PHST- 2024/07/21 00:00 [revised] PHST- 2024/07/29 00:00 [accepted] PHST- 2024/11/13 13:52 [medline] PHST- 2024/08/03 10:41 [pubmed] PHST- 2024/08/02 19:24 [entrez] PHST- 2025/12/12 00:00 [pmc-release] AID - S0022-3476(24)00322-6 [pii] AID - 10.1016/j.jpeds.2024.114219 [doi] PST - ppublish SO - J Pediatr. 2024 Dec;275:114219. doi: 10.1016/j.jpeds.2024.114219. Epub 2024 Jul 31. PMID- 39090725 OWN - NLM STAT- MEDLINE DCOM- 20240802 LR - 20250519 IS - 1743-0003 (Electronic) IS - 1743-0003 (Linking) VI - 21 IP - 1 DP - 2024 Aug 1 TI - A usability study on the inGAIT-VSO: effects of a variable-stiffness ankle-foot orthosis on the walking performance of children with cerebral palsy. PG - 132 LID - 10.1186/s12984-024-01433-7 [doi] LID - 132 AB - BACKGROUND: Ankle-foot orthoses (AFOs) are commonly used by children with cerebral palsy (CP), but traditional solutions are unable to address the heterogeneity and evolving needs amongst children with CP. One key limitation lies in the inability of current passive devices to customize the torque-angle relationship, which is essential to adapt the support to the specific individual needs. Powered alternatives can provide customized behavior, but often face challenges with reliability, weight, and cost. Overall, clinicians find certain barriers that hinder their prescription. In recent work, the Variable Stiffness Orthosis (VSO) was developed, enabling stiffness customization without the need for motors or sophisticated control. METHODS: This work evaluates a pediatric version of the VSO (inGAIT-VSO) by investigating its impact on the walking performance of children with CP and its potential to be used as a tool for assessing the effect of variable stiffness on pathological gait. Data was collected for three typical developing (TD) children and six pediatric participants with CP over two sessions involving walking/balance tasks and questionnaires. RESULTS: The sensors of the inGAIT-VSO provided useful information to assess the impact of the device. Increasing the stiffness of the inGAIT-VSO significantly reduced participants' dorsiflexion and plantarflexion. Despite reduced range of motion, the peak restoring torque increased with stiffness. Overall the participants' gait pattern was altered by reducing crouch gait, preventing drop-foot and supporting body weight. Participants with CP exhibited significantly lower (p < 0.05) physiological cost when walking with the inGAIT-VSO compared to normal condition (own AFO or shoes only). Generally, the device did not impair walking and balance of the participants compared to normal conditions. According to the questionnaire results, the inGAIT-VSO was easy to use and participants reported positive experiences. CONCLUSION: The inGAIT-VSO stiffnesses significantly affected participants' plantarflexion and dorsiflexion and yielded objective data regarding walking performance in pathological gait (e.g. ankle angle, exerted torque and restored assistive energy). These effects were captured by the sensors integrated in the device without using external equipment. The inGAIT-VSO shows promise for customizing AFO stiffness and aiding clinicians in selecting a personalized stiffness based on objective metrics. CI - (c) 2024. The Author(s). FAU - van Noort, Luc AU - van Noort L AD - Centro de Automatica y Robotica, Consejo Superior de Investigaciones Cientificas, CAR-CSIC-UPM, Madrid, Spain. AD - Department of Biomechanical Engineering, University of Twente, Enschede, The Netherlands. FAU - Van Crey, Nikko AU - Van Crey N AD - Department of Robotics, University of Michigan, Michigan, United States. FAU - Rouse, Elliott J AU - Rouse EJ AD - Department of Robotics, University of Michigan, Michigan, United States. AD - Department of Mechanical Engineering, University of Michigan, Michigan, United States. FAU - Martinez-Caballero, Ignacio AU - Martinez-Caballero I AD - Hospital Infantil Universitario Nino Jesus, Madrid, Spain. FAU - van Asseldonk, Edwin H F AU - van Asseldonk EHF AD - Department of Biomechanical Engineering, University of Twente, Enschede, The Netherlands. FAU - Bayon, Cristina AU - Bayon C AD - Centro de Automatica y Robotica, Consejo Superior de Investigaciones Cientificas, CAR-CSIC-UPM, Madrid, Spain. c.bayon@csic.es. AD - Department of Biomechanical Engineering, University of Twente, Enschede, The Netherlands. c.bayon@csic.es. LA - eng GR - DGE-1841052/National Science Foundation Graduate Research Fellowship Program/ GR - Veni-TTW-2020, no. 18079/Nederlandse Organisatie voor Wetenschappelijk Onderzoek/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240801 PL - England TA - J Neuroeng Rehabil JT - Journal of neuroengineering and rehabilitation JID - 101232233 SB - IM MH - Humans MH - *Cerebral Palsy/rehabilitation/physiopathology MH - Child MH - Male MH - *Foot Orthoses MH - *Walking/physiology MH - Female MH - *Ankle/physiopathology/physiology MH - Adolescent MH - Gait Disorders, Neurologic/rehabilitation/etiology/physiopathology MH - Equipment Design MH - Biomechanical Phenomena MH - Postural Balance/physiology MH - Foot/physiopathology PMC - PMC11293312 OTO - NOTNLM OT - Ankle stiffness OT - Ankle-foot orthosis OT - Assistive technology OT - Cerebral palsy OT - Gait COIS- The authors declare that they have no competing interests. EDAT- 2024/08/02 00:46 MHDA- 2024/08/02 06:42 PMCR- 2024/08/01 CRDT- 2024/08/01 23:52 PHST- 2024/04/30 00:00 [received] PHST- 2024/07/24 00:00 [accepted] PHST- 2024/08/02 06:42 [medline] PHST- 2024/08/02 00:46 [pubmed] PHST- 2024/08/01 23:52 [entrez] PHST- 2024/08/01 00:00 [pmc-release] AID - 10.1186/s12984-024-01433-7 [pii] AID - 1433 [pii] AID - 10.1186/s12984-024-01433-7 [doi] PST - epublish SO - J Neuroeng Rehabil. 2024 Aug 1;21(1):132. doi: 10.1186/s12984-024-01433-7. PMID- 39090633 OWN - NLM STAT- MEDLINE DCOM- 20240802 LR - 20250130 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 Aug 1 TI - An investigation into social determinants of health lifestyles of Canadians: a nationwide cross-sectional study on smoking, physical activity, and alcohol consumption. PG - 2080 LID - 10.1186/s12889-024-19427-4 [doi] LID - 2080 AB - BACKGROUND: Health lifestyles exert a substantial influence on the quality of everyday life, primarily affecting health maintenance and enhancement. While health-related practices during the COVID-19 pandemic may have positively altered the health lifestyles of Canadians to a certain degree, government reports indicate that issues related to health behaviors, such as cigarette smoking, physical inactivity, and alcohol consumption, continue to pose challenges to the health of Canadians. Social determinants of these health behaviors thus hold significant academic value in the formulation of policy guidelines. OBJECTIVE: The aim of this study is to scrutinize the social determinants of health with respect to social factors that have may have impacts on the health-related behaviors of Canadians. We tested health behaviors including cigarette use, alcohol consumption, and participation in physical exercise, which are integral to the promotion and improvement of individual health. METHODS: To examine the social determinants of Canadians' health lifestyles, we utilized nationally representative data from the 2017-2018 Canadian Community Health Survey annual component. Our data analysis involved the bootstrapping method with two-level mixed-effect logistic regressions, ordered logistic regressions, and negative binomial regressions. Additionally, we conducted several robustness checks to confirm the validity of our findings. RESULTS: The findings show that demographic background, socioeconomic status, social connections, and physical and mental health conditions all play a role in Canadians' smoking, physical activity, and drinking behaviors. Noticeably, the association patterns linking to these social determinants vary across specific health lifestyles, shedding light on the complex nature of the social determinants that may influence young and middle-aged Canadians' health lifestyles. Moreover, in the context of Canada, the health-region level demographic, socioeconomic, and working conditions are significantly linked to residents' health lifestyles. CONCLUSIONS: Investigating the social determinants of health lifestyles is pivotal for policymakers, providing them with the necessary insights to create effective interventions that promote healthy behaviors among specific demographic groups. It is recommended that health education and interventions at the community level targeting smoking, physical inactivity, and alcohol consumption be introduced. These interventions should be tailored to specific subgroups, considering their demographic and socioeconomic characteristics, social networks, and health status. For instance, it is imperative to focus our attention on individuals with lower educational attainment and socioeconomic status, particularly in relation to their smoking habits and physical inactivity. Conversely, interventions aimed at addressing alcohol consumption should be targeted towards individuals of a higher socioeconomic status. This nuanced approach allows for a more effective and tailored intervention strategy. CI - (c) 2024. The Author(s). FAU - Chai, Xiangnan AU - Chai X AD - Department of Sociology, School of Social and Behavioral Sciences, Nanjing University, Nanjing, Jiangsu, P. R. China. westerncxn@gmail.com. FAU - Tan, Yongzhen AU - Tan Y AD - Law School, Shihezi University, Shihezi, Xinjiang, P. R. China. FAU - Dong, Yanfei AU - Dong Y AD - Department of Social Work and Social Policy, School of Social and Behavioral Sciences, Nanjing University, Nanjing, Jiangsu, P. R. China. LA - eng GR - 20SHC003/Jiangsu Planning Office of Philosophy and Social Science/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240801 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - Canadian people SB - IM MH - Humans MH - Canada/epidemiology MH - *Alcohol Drinking/epidemiology/psychology MH - *Social Determinants of Health MH - Male MH - Female MH - Adult MH - Cross-Sectional Studies MH - Middle Aged MH - *Exercise MH - *Smoking/epidemiology/psychology MH - Young Adult MH - Aged MH - Adolescent MH - Health Surveys MH - Health Behavior MH - Life Style MH - COVID-19/epidemiology/prevention & control MH - North American People PMC - PMC11293084 OTO - NOTNLM OT - Alcohol drinking OT - Canadian adults OT - Cigarette smoking OT - Health lifestyles OT - Health region of Canada OT - Physical activity OT - Social determinants of health COIS- The authors declare no competing interests. EDAT- 2024/08/02 00:47 MHDA- 2024/08/02 06:42 PMCR- 2024/08/01 CRDT- 2024/08/01 23:48 PHST- 2024/01/07 00:00 [received] PHST- 2024/07/10 00:00 [accepted] PHST- 2024/08/02 06:42 [medline] PHST- 2024/08/02 00:47 [pubmed] PHST- 2024/08/01 23:48 [entrez] PHST- 2024/08/01 00:00 [pmc-release] AID - 10.1186/s12889-024-19427-4 [pii] AID - 19427 [pii] AID - 10.1186/s12889-024-19427-4 [doi] PST - epublish SO - BMC Public Health. 2024 Aug 1;24(1):2080. doi: 10.1186/s12889-024-19427-4. PMID- 39089174 OWN - NLM STAT- MEDLINE DCOM- 20240822 LR - 20250211 IS - 1476-5616 (Electronic) IS - 0033-3506 (Linking) VI - 234 DP - 2024 Sep TI - Association between dietary patterns and obesity: a longitudinal prospective cohort study. PG - 217-223 LID - S0033-3506(24)00138-0 [pii] LID - 10.1016/j.puhe.2024.04.002 [doi] AB - OBJECTIVES: The obesity prevalence in South Korea in 2021 stood at 38.4%. South Korea faces unique challenges in providing essential and emergency guidelines for weight management because of stepping into an aging society. We aimed to determine the daily diet patterns among the general Korean population and to investigate the association between such patterns and different obesity. STUDY DESIGN: Longitudinal prospective cohort study. METHODS: A total of 6539 adult participants (mean age 50.8 years, 52.9% male) with normal-weight adults were included from the Ansan-Ansung cohort of 10,030 Korean adults aged 40 or older and followed for an average of 11 years. Obesity was defined according to the criteria from the Korean Society for The Study of Obesity. Baseline dietary intake was assessed using a validated 103-item food frequency questionnaire. Dietary patterns were derived from k-means cluster analysis. RESULTS: In the multivariate analysis, referring to white rice + baechu kimchi, participants from multigrain rice + baechu kimchi showed lower HR for obesity development (waist circumference defined-obesity; HR: 0.87, 95% CI: 0.79, 0.95; body fat percentage defined-obesity; HR: 0.89, 95% CI: 0.80, 0.98). Further analysis documented that except for body fat percentage defined-obesity, consuming milk or dairy products was linked to a reduced incidence of the other three obesity (body mass index defined-obesity; HR: 0.84, 95% CI: 0.72, 0.99; waist circumference defined-obesity; HR: 0.82, 95% CI: 0.71, 0.94; waist-to-hip ratio defined-obesity; HR: 0.75, 95% CI: 0.61, 0.91). CONCLUSIONS: Following a diet that includes multigrain rice, fermented baechu kimchi, and dairy products is linked to a decreased risk of obesity in Korean adults. Public health programs and policies could incorporate these dietary recommendations, targeting specific population groups such as schoolchildren, adults, and the elderly. Additionally, further research is needed to explore the synergistic effects of various foods and their interactions within dietary patterns on obesity outcomes. CI - Copyright (c) 2024 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved. FAU - Tan, L-J AU - Tan LJ AD - Department of Food and Nutrition, Chung-Ang University, Gyeonggi-do 17546, South Korea. FAU - Oh, S-J AU - Oh SJ AD - Department of Food and Nutrition, Chung-Ang University, Gyeonggi-do 17546, South Korea. FAU - Nasan-Ulzii, B AU - Nasan-Ulzii B AD - Department of Food and Nutrition, Chung-Ang University, Gyeonggi-do 17546, South Korea. FAU - Lee, W AU - Lee W AD - Technology Innovation Research Division, World Institute of Kimchi, Gwangju 61755, South Korea. FAU - Hong, S W AU - Hong SW AD - Technology Innovation Research Division, World Institute of Kimchi, Gwangju 61755, South Korea. Electronic address: swhong@wikim.re.kr. FAU - Shin, S AU - Shin S AD - Department of Food and Nutrition, Chung-Ang University, Gyeonggi-do 17546, South Korea. Electronic address: ivory8320@cau.ac.kr. LA - eng PT - Journal Article DEP - 20240801 PL - Netherlands TA - Public Health JT - Public health JID - 0376507 SB - IM MH - Adult MH - Female MH - Humans MH - Male MH - Middle Aged MH - Longitudinal Studies MH - *Obesity/epidemiology/etiology/prevention & control MH - Prospective Studies MH - Republic of Korea/epidemiology OTO - NOTNLM OT - Cluster pattern analysis OT - Dietary pattern OT - Obesity OT - Traditional fermented vegetables EDAT- 2024/08/02 00:46 MHDA- 2024/08/23 00:43 CRDT- 2024/08/01 18:09 PHST- 2023/12/14 00:00 [received] PHST- 2024/04/02 00:00 [revised] PHST- 2024/04/03 00:00 [accepted] PHST- 2024/08/23 00:43 [medline] PHST- 2024/08/02 00:46 [pubmed] PHST- 2024/08/01 18:09 [entrez] AID - S0033-3506(24)00138-0 [pii] AID - 10.1016/j.puhe.2024.04.002 [doi] PST - ppublish SO - Public Health. 2024 Sep;234:217-223. doi: 10.1016/j.puhe.2024.04.002. Epub 2024 Aug 1. PMID- 39087706 OWN - NLM STAT- MEDLINE DCOM- 20241103 LR - 20260822 IS - 2576-9456 (Print) IS - 2475-7241 (Linking) VI - 9 IP - 6 DP - 2024 Nov 4 TI - Glycated Albumin to Predict Adverse Neonatal Outcomes among Women with Diabetes and Overweight or Obese Body Mass Index. PG - 938-948 LID - 10.1093/jalm/jfae079 [doi] AB - BACKGROUND: Glycated albumin (GA) has shown promise in predicting risk of adverse neonatal outcomes (ANO) in pregnant women with type 2 diabetes (T2DM) and gestational diabetes (GDM). However, previous studies showing a negative correlation between GA and body mass index (BMI) suggest that lower predictive cutoffs may be needed in populations with elevated BMI. METHODS: We performed a case-control study of prospectively enrolled pregnant women with T2DM or GDM and BMI >/=25 kg/m2 matched to biobanked controls without diabetes. Serum collected during the second and/or third trimesters was used to measure the percentage of GA (% GA). Receiver operating characteristic (ROC) curves were used to examine % GA to predict an ANO composite, including macrosomia, hypoglycemia, respiratory distress syndrome, and/or hyperbilirubinemia for the second and third trimesters. RESULTS: The median BMIs for cases and controls were 34.0 and 31.0 kg/m2, respectively. The area under the ROC curve to predict the ANO composite was significant for second trimester values but ambiguous for third trimester due to its wide 95% CI. A cutoff of 12.3% GA during second trimester showed 100% sensitivity and 73% specificity. Transference of previously published reference ranges did not validate, suggesting lower ranges are needed for women with overweight/obesity. CONCLUSIONS: In this pilot study, % GA shows promise to stratify pregnant patients with diabetes and obesity into risk categories for ANO with excellent predictive ability in the second trimester. If this holds in larger studies, using second trimester % GA could allow additional intervention to improve blood glucose control and minimize ANO. CI - (c) Association for Diagnostics & Laboratory Medicine 2024. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Powers Carson, Jennifer AU - Powers Carson J AUID- ORCID: 0000-0002-0181-5012 AD - Division of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States. FAU - Arora, Jyoti AU - Arora J AD - Center for Biostatistics and Data Science, Washington University School of Medicine, St. Louis, MO, United States. FAU - Carter, Ebony AU - Carter E AD - Divison of Maternal-Fetal Medicine & Ultrasound, Department of Obstetrics & Gynecology, Washington University School of Medicine, St. Louis, MO, United States. LA - eng GR - P30 DK020579/DK/NIDDK NIH HHS/United States GR - K23 HD095075/HD/NICHD NIH HHS/United States GR - UL1 TR002345/TR/NCATS NIH HHS/United States GR - P30 CA091842/CA/NCI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PL - England TA - J Appl Lab Med JT - The journal of applied laboratory medicine JID - 101693884 RN - 0 (Glycated Serum Albumin) RN - 0 (Glycation End Products, Advanced) RN - 0 (Serum Albumin) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Glycated Serum Albumin MH - *Glycation End Products, Advanced/blood MH - *Body Mass Index MH - Case-Control Studies MH - *Diabetes, Gestational/blood/diagnosis MH - Adult MH - *Diabetes Mellitus, Type 2/blood/diagnosis/complications MH - *Obesity/blood/diagnosis/complications MH - *Serum Albumin/analysis MH - Infant, Newborn MH - Overweight/blood/diagnosis/complications MH - ROC Curve MH - Biomarkers/blood MH - Pregnancy Outcome/epidemiology MH - Prospective Studies EDAT- 2024/08/01 12:44 MHDA- 2024/11/04 00:31 CRDT- 2024/08/01 08:14 PHST- 2023/09/13 00:00 [received] PHST- 2024/05/28 00:00 [accepted] PHST- 2024/11/04 00:31 [medline] PHST- 2024/08/01 12:44 [pubmed] PHST- 2024/08/01 08:14 [entrez] AID - 7725538 [pii] AID - 10.1093/jalm/jfae079 [doi] PST - ppublish SO - J Appl Lab Med. 2024 Nov 4;9(6):938-948. doi: 10.1093/jalm/jfae079. PMID- 39086814 OWN - NLM STAT- MEDLINE DCOM- 20240801 LR - 20260609 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 12 DP - 2024 TI - The Knowledge, Attitudes, and Practices of Healthy Eating Questionnaire: a pilot validation study in Chinese families. PG - 1355638 LID - 10.3389/fpubh.2024.1355638 [doi] LID - 1355638 AB - INTRODUCTION: Identifying the knowledge, attitudes, and practices (KAP) gaps of healthy eating can inform the design of effective interventions. This study aimed to test the validity and psychometric properties of a KAP of Healthy Eating Questionnaire (KAP-HEQ) tailored to the Chinese culture. METHODS: The dimensions and potential items of each KAP scale were identified from published KAP and health literacy questionnaires, which were supplemented by the findings of a previous qualitative healthy eating study. Content validity of the KAP-HEQ was evaluated by eight experts and eight Chinese parent-adolescent dyads in Hong Kong through content validity ratio (CVR), content validity index (CVI), and qualitative feedback. The feasibility, construct validity, reliability, and sensitivity of the KAP-HEQ were evaluated in this pilot study among 60 adolescent-parent dyads (120 persons) through an online survey. The first 30 dyads who completed the KAP-HEQ were invited to repeat the KAP-HEQ 2 weeks later to assess the test-retest reliability. RESULTS: The final 44-item KAP-HEQ was completed in 10-15 min by both adolescents and their adult parents. The CVR ranged from -0.38 to 1, and the CVI ranged from 0.56 to 1. Over 80% of the items achieved convergent validity (a significantly positive correlation with its hypothesized scale) and discriminant validity (a higher correlation with its hypothesized scale than with the other two scales). Cronbach's alpha for the internal consistency of the Overall, Attitude, and Practice scales was >0.7, while that of the Knowledge scale was 0.54. The intraclass correlation coefficient (ICC) on test-retest reliability of the Overall and individual scales were all >0.75 except that of the Knowledge scale (ICC = 0.58). The significant differences in KAP scale scores with small to large effect sizes were found between known groups as hypothesized, except the Attitude score between groups by household income, which supported the sensitivity of the KAP-HEQ. CONCLUSION: The KAP-HEQ has shown good validity, reliability, and sensitivity among Chinese adolescents and adults, which can be applied to evaluate KAP status and gaps to inform the design and assess the effectiveness of healthy eating interventions. CI - Copyright (c) 2024 Liu, Chen, Sun, Tsang, Ip, Wong and Lam. FAU - Liu, Kiki S N AU - Liu KSN AD - Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China. FAU - Chen, Julie Y AU - Chen JY AD - Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China. AD - Department of Family Medicine, The University of Hong Kong Shenzhen Hospital, Shenzhen, China. FAU - Sun, Kai-Sing AU - Sun KS AD - JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China. FAU - Tsang, Joyce P Y AU - Tsang JPY AD - Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China. AD - School of Health Sciences, Saint Francis University, Hong Kong, Hong Kong SAR, China. FAU - Ip, Patrick AU - Ip P AD - Department of Paediatrics and Adolescent Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China. FAU - Wong, Carlos K H AU - Wong CKH AD - Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China. AD - Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China. AD - Laboratory of Data Discovery for Health Limited (D24H), Hong Kong, Hong Kong SAR, China. AD - Department of Infectious Disease Epidemiology and Dynamics, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom. FAU - Lam, Cindy L K AU - Lam CLK AD - Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China. AD - Department of Family Medicine, The University of Hong Kong Shenzhen Hospital, Shenzhen, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20240717 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Surveys and Questionnaires/standards MH - Pilot Projects MH - Male MH - Female MH - Adolescent MH - *Health Knowledge, Attitudes, Practice MH - Hong Kong MH - Reproducibility of Results MH - *Psychometrics MH - *Diet, Healthy MH - Adult MH - Parents/psychology MH - Middle Aged MH - East Asian People PMC - PMC11288980 OTO - NOTNLM OT - Chinese OT - KAP OT - healthy eating OT - questionnaire OT - validation COIS- CW was employed by the Laboratory of Data Discovery for Health Limited (D24H). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/08/01 06:41 MHDA- 2024/08/01 12:42 PMCR- 2024/07/17 CRDT- 2024/08/01 04:19 PHST- 2023/12/14 00:00 [received] PHST- 2024/07/03 00:00 [accepted] PHST- 2024/08/01 12:42 [medline] PHST- 2024/08/01 06:41 [pubmed] PHST- 2024/08/01 04:19 [entrez] PHST- 2024/07/17 00:00 [pmc-release] AID - 10.3389/fpubh.2024.1355638 [doi] PST - epublish SO - Front Public Health. 2024 Jul 17;12:1355638. doi: 10.3389/fpubh.2024.1355638. eCollection 2024. PMID- 39086341 OWN - NLM STAT- MEDLINE DCOM- 20240801 LR - 20240801 IS - 0300-5283 (Print) IS - 0300-5283 (Linking) VI - 79 IP - 4 DP - 2024 Jul TI - Stunting and its association with feeding problem among under five children: a case-control study in Kuantan district, Malaysia. PG - 436-442 AB - INTRODUCTION: Stunting is the most prevalent form of malnutrition among infants and young children population, both globally and locally. It refers to low height-for-age children and is primarily caused by chronic under nutrition. The objective of this study is to determine the association between stunting and feeding problems and to explore the risk factors for stunting among children aged 6 to 59 months attending health clinics in the Kuantan district. MATERIALS AND METHODS: A case-control study involving 160 children that attended six health clinics in Kuantan from August to October 2021 with a ratio of 1 case: 3 controls. Data were collected from mothers using a questionnaire consisting of sociodemographic and feeding assessment adapted from a validated World Health Organization (WHO) integrated management of childhood illness (IMCI) assessment form. The data was analysed using IBM SPSS version 26.0. Binary logistic regression analysis was used to identify factors associated with stunting. The odds ratio was used to measure the strength of the association between outcome and predictor variables. The significance value was set at p<0.05. RESULTS: Children with identified feeding problems have more than four-time significantly higher risk of becoming stunted (Odds Ratios, OR: 4.2; 95% Confidence Intervals, 95%CI: 1.4, 12.8) as compared to children with no feeding problems. Specifically, children with inadequacy in feeding components; amount, variety and frequency of meal each have significantly six-time higher risk (OR: 6.2; 95%CI: 2.7, 14.5), four-time higher risk (OR: 4.2; 95%CI: 1.4, 12.3), and three-time higher risk (OR: 2.8; 95%CI: 1.1, 6.9), of becoming stunted as compared to children with adequate feeding. Additionally, with a decrease of one week in delivery week, one kilogram in birth weight and one centimetre in maternal height, there is a respectively significant 40.0% (OR: 0.6; 95%CI: 0.4, 0.9), 80.0% (OR: 0.2; 95%CI: 0.1, 0.7) and 11.0% (OR: 0.89; 95%CI: 0.82, 0.98) increase in the risk of become stunted among children. CONCLUSION: Feeding problems specifically inadequate food amount, food variety and meal frequency not following the recommendation contribute to stunting in young children. Other factors identified are lower maternal height and children with lower birth weight and delivery week. This highlights the need for more excellent detection and intervention of nutritional concerns and risk factors to prevent stunting. FAU - Kamaruzaman, N A AU - Kamaruzaman NA AD - International Islamic University Malaysia, Kulliyyah of Medicine, Department of Family Medicine, Kuantan, Pahang, Malaysia. FAU - Musa, A L AU - Musa AL AD - International Islamic University Malaysia, Kulliyyah of Medicine, Department of Family Medicine, Kuantan, Pahang, Malaysia. norainibtmusa88@gmail.com;ainimusa_1988@yahoo.com. FAU - Pasi, H AU - Pasi H AD - International Islamic University Malaysia, Kulliyyah of Medicine, Department of Community Medicine, Kuantan, Pahang, Malaysia. FAU - Osman, I F AU - Osman IF AD - Klinik Kesihatan Jaya Gading, Kuantan, Pahang, Malaysia. LA - eng PT - Journal Article PL - Malaysia TA - Med J Malaysia JT - The Medical journal of Malaysia JID - 0361547 SB - IM MH - Humans MH - Case-Control Studies MH - Infant MH - Malaysia/epidemiology MH - Female MH - Child, Preschool MH - *Growth Disorders/epidemiology/etiology MH - Male MH - Risk Factors MH - Feeding and Eating Disorders/epidemiology EDAT- 2024/08/01 06:42 MHDA- 2024/08/01 12:43 CRDT- 2024/08/01 04:03 PHST- 2024/08/01 12:43 [medline] PHST- 2024/08/01 06:42 [pubmed] PHST- 2024/08/01 04:03 [entrez] PST - ppublish SO - Med J Malaysia. 2024 Jul;79(4):436-442. PMID- 39085943 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240803 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 12 IP - 1 DP - 2024 Jul 31 TI - Correction: Chinese version of the tendency to avoid physical activity and Sport (TAPAS) scale: testing unidimensionality, measurement invariance, concurrent validity, and known-group validity among Taiwanese youths. PG - 418 LID - 10.1186/s40359-024-01912-5 [doi] LID - 418 FAU - Lin, Yi-Ching AU - Lin YC AUID- ORCID: 0000-0002-6835-7116 AD - Department of Early Childhood and Family Education, National Taipei University of Education, Taipei, Taiwan. FAU - Chen, Jung-Sheng AU - Chen JS AUID- ORCID: 0000-0003-3187-9479 AD - Department of Medical Research, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan. FAU - Bevan, Nadia AU - Bevan N AUID- ORCID: 0000-0002-5213-4057 AD - School of Social Sciences, Monash University, Melbourne, 3800, Australia. FAU - O'Brien, Kerry S AU - O'Brien KS AUID- ORCID: 0000-0003-3145-6038 AD - School of Social Sciences, Monash University, Melbourne, 3800, Australia. FAU - Strong, Carol AU - Strong C AUID- ORCID: 0000-0002-2934-5382 AD - Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan. FAU - Tsai, Meng-Che AU - Tsai MC AUID- ORCID: 0000-0003-1057-3315 AD - Department of Pediatrics, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan. AD - Department of Medical Humanities and Social Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. FAU - Fung, Xavier C C AU - Fung XCC AUID- ORCID: 0000-0002-0170-6203 AD - Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China. FAU - Chen, Ji-Kang AU - Chen JK AUID- ORCID: 0000-0001-7762-3888 AD - Department of Social Work, Chinese University of Hong Kong, New Territories, Hong Kong, China. FAU - Lin, I-Ching AU - Lin IC AUID- ORCID: 0000-0002-1418-4977 AD - Department of Healthcare Administration, Department of Family Medicine, Asia University, Taichung, 41354, Taiwan. D52282@auh.org.tw. AD - Department of Family Medicine, Asia University Hospital, Taichung, 41354, Taiwan. D52282@auh.org.tw. AD - Department of Kinesiology, Health, and Leisure, Chienkuo Technology University, Changhua, 50094, Taiwan. D52282@auh.org.tw. FAU - Latner, Janet D AU - Latner JD AD - Department of Psychology, University of Hawaii, Honolulu, HI, 96822, USA. FAU - Lin, Chung-Ying AU - Lin CY AUID- ORCID: 0000-0002-2129-4242 AD - Institute of Allied Health Sciences, Departments of Occupational Therapy and Public Health, Biostatistics Consulting Center, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, 1 University Rd, Tainan, 701401, Taiwan. cylin36933@gmail.com. AD - University of Religions and Denominations, Qom, Iran. cylin36933@gmail.com. AD - Biostatistics Consulting Center, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan. cylin36933@gmail.com. AD - Faculty of Nursing, Universitas Padjadjaran, Sumedang, Indonesia. cylin36933@gmail.com. LA - eng PT - Published Erratum DEP - 20240731 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM EFR - BMC Psychol. 2024 Jul 8;12(1):381. doi: 10.1186/s40359-024-01870-y. PMID: 38978147 PMC - PMC11292882 EDAT- 2024/08/01 00:41 MHDA- 2024/08/01 00:42 PMCR- 2024/07/31 CRDT- 2024/07/31 23:54 PHST- 2024/08/01 00:42 [medline] PHST- 2024/08/01 00:41 [pubmed] PHST- 2024/07/31 23:54 [entrez] PHST- 2024/07/31 00:00 [pmc-release] AID - 10.1186/s40359-024-01912-5 [pii] AID - 1912 [pii] AID - 10.1186/s40359-024-01912-5 [doi] PST - epublish SO - BMC Psychol. 2024 Jul 31;12(1):418. doi: 10.1186/s40359-024-01912-5. PMID- 39085406 OWN - NLM STAT- MEDLINE DCOM- 20241021 LR - 20261028 IS - 2397-3374 (Electronic) IS - 2397-3374 (Linking) VI - 8 IP - 10 DP - 2024 Oct TI - Power and reproducibility in the external validation of brain-phenotype predictions. PG - 2018-2033 LID - 10.1038/s41562-024-01931-7 [doi] AB - Brain-phenotype predictive models seek to identify reproducible and generalizable brain-phenotype associations. External validation, or the evaluation of a model in external datasets, is the gold standard in evaluating the generalizability of models in neuroimaging. Unlike typical studies, external validation involves two sample sizes: the training and the external sample sizes. Thus, traditional power calculations may not be appropriate. Here we ran over 900 million resampling-based simulations in functional and structural connectivity data to investigate the relationship between training sample size, external sample size, phenotype effect size, theoretical power and simulated power. Our analysis included a wide range of datasets: the Healthy Brain Network, the Adolescent Brain Cognitive Development Study, the Human Connectome Project (Development and Young Adult), the Philadelphia Neurodevelopmental Cohort, the Queensland Twin Adolescent Brain Project, and the Chinese Human Connectome Project; and phenotypes: age, body mass index, matrix reasoning, working memory, attention problems, anxiety/depression symptoms and relational processing. High effect size predictions achieved adequate power with training and external sample sizes of a few hundred individuals, whereas low and medium effect size predictions required hundreds to thousands of training and external samples. In addition, most previous external validation studies used sample sizes prone to low power, and theoretical power curves should be adjusted for the training sample size. Furthermore, model performance in internal validation often informed subsequent external validation performance (Pearson's r difference <0.2), particularly for well-harmonized datasets. These results could help decide how to power future external validation studies. CI - (c) 2024. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Rosenblatt, Matthew AU - Rosenblatt M AUID- ORCID: 0000-0002-3894-6198 AD - Department of Biomedical Engineering, Yale University, New Haven, CT, USA. matthew.rosenblatt@yale.edu. FAU - Tejavibulya, Link AU - Tejavibulya L AUID- ORCID: 0000-0001-5643-9133 AD - Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA. FAU - Sun, Huili AU - Sun H AD - Department of Biomedical Engineering, Yale University, New Haven, CT, USA. FAU - Camp, Chris C AU - Camp CC AD - Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA. FAU - Khaitova, Milana AU - Khaitova M AD - Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA. FAU - Adkinson, Brendan D AU - Adkinson BD AUID- ORCID: 0000-0003-3196-8674 AD - Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA. FAU - Jiang, Rongtao AU - Jiang R AUID- ORCID: 0000-0003-4657-0079 AD - Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA. FAU - Westwater, Margaret L AU - Westwater ML AD - Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA. FAU - Noble, Stephanie AU - Noble S AUID- ORCID: 0000-0002-4804-5553 AD - Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA. AD - Department of Bioengineering, Northeastern University, Boston, MA, USA. AD - Department of Psychology, Northeastern University, Boston, MA, USA. FAU - Scheinost, Dustin AU - Scheinost D AUID- ORCID: 0000-0002-6301-1167 AD - Department of Biomedical Engineering, Yale University, New Haven, CT, USA. AD - Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA. AD - Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA. AD - Child Study Center, Yale School of Medicine, New Haven, CT, USA. AD - Department of Statistics and Data Science, Yale University, New Haven, CT, USA. LA - eng GR - T32GM136651/U.S. Department of Health & Human Services | National Institutes of Health (NIH)/ GR - R01MH121095/U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)/ GR - T32DA022975/U.S. Department of Health & Human Services | National Institutes of Health (NIH)/ GR - DGE2139841/National Science Foundation (NSF)/ GR - R01 MH121095/MH/NIMH NIH HHS/United States GR - R00MH130894/U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)/ PT - Journal Article DEP - 20240731 PL - England TA - Nat Hum Behav JT - Nature human behaviour JID - 101697750 SB - IM UOF - bioRxiv. 2023 Oct 30:2023.10.25.563971. doi: 10.1101/2023.10.25.563971. PMID: 37961654 MH - Humans MH - *Phenotype MH - *Connectome/methods MH - *Brain/diagnostic imaging/physiology MH - Reproducibility of Results MH - Adolescent MH - Young Adult MH - Adult MH - Sample Size MH - Male MH - Female PMC - PMC13711221 MID - NIHMS2211675 COIS- Competing interests The authors declare no competing interests. EDAT- 2024/08/01 00:42 MHDA- 2024/10/22 00:21 PMCR- 2026/10/27 CRDT- 2024/07/31 23:29 PHST- 2023/10/30 00:00 [received] PHST- 2024/06/18 00:00 [accepted] PHST- 2024/10/22 00:21 [medline] PHST- 2024/08/01 00:42 [pubmed] PHST- 2024/07/31 23:29 [entrez] PHST- 2026/10/27 00:00 [pmc-release] AID - 10.1038/s41562-024-01931-7 [pii] AID - 10.1038/s41562-024-01931-7 [doi] PST - ppublish SO - Nat Hum Behav. 2024 Oct;8(10):2018-2033. doi: 10.1038/s41562-024-01931-7. Epub 2024 Jul 31. PMID- 39082599 OWN - NLM STAT- MEDLINE DCOM- 20240731 LR - 20240814 IS - 1518-8787 (Electronic) IS - 0034-8910 (Print) IS - 0034-8910 (Linking) VI - 58 DP - 2024 TI - Validation of self-reported measures of nutritional status: a study based on the PNS 2019. PG - 28 LID - S0034-89102024000100223 [pii] LID - 10.11606/s1518-8787.2024058005505 [doi] LID - 28 AB - The aim of this study was to analyze the validity of self-reported anthropometric measurements (weight and height) for classifying the nutritional status of Brazilian adults and elderly people using data from the 2019 National Health Survey (PNS). The PNS sample is made up of permanent private households from all of Brazil's federative units and this is a cross-sectional study in which 6,571 records were identified with measured and reported data, with no missing data for one variable being identified when in the presence of another. Validation was carried out with 6,381 data after removing atypical data. The variables used for stratification were: gender, age, race/color, schooling, and income, and the weighted Kappa Coefficient and the Intraclass Correlation Coefficient (ICC) were used to analyze agreement between the nutritional status categories. Accuracy was analyzed based on sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV). For construct validity, a Poisson regression was performed for each outcome (measured and self-reported), with the independent variables "gender", "color/race", "schooling", and "family income". All the analyses showed positive results for validation. There was greater reproducibility among adults (18 to 59 years old) compared to the elderly and among men compared to women. This validation indicates a concrete possibility of carrying out an association of observational studies using reported nutritional status as the outcome variable, as an efficient strategy which could minimize the operational difficulties often encountered. FAU - Brito, Renatha Celiana da Silva AU - Brito RCDS AUID- ORCID: 0000-0002-9712-1321 AD - Universidade Federal do Rio Grande do Norte. Programa de Pos-Graduacao em Saude Coletiva. Natal, RN, Brasil. FAU - Oliveira, Angelo Giuseppe Roncalli da Costa AU - Oliveira AGRDC AUID- ORCID: 0000-0001-5311-697X AD - Universidade Federal do Rio Grande do Norte. Departamento de Odontologia. Natal, RN, Brasil. LA - eng LA - por PT - Journal Article PT - Validation Study DEP - 20240726 PL - Brazil TA - Rev Saude Publica JT - Revista de saude publica JID - 0135043 SB - IM MH - Humans MH - Male MH - Female MH - Brazil MH - *Nutritional Status MH - Middle Aged MH - Adult MH - *Self Report MH - Cross-Sectional Studies MH - Reproducibility of Results MH - Aged MH - Adolescent MH - Young Adult MH - Socioeconomic Factors MH - Body Weight MH - Body Height MH - Health Surveys MH - Sensitivity and Specificity MH - Nutrition Surveys PMC - PMC11319040 COIS- Conflict of Interest: The authors declare no conflict of interest. EDAT- 2024/07/31 12:43 MHDA- 2024/07/31 12:44 PMCR- 2024/07/10 CRDT- 2024/07/31 07:44 PHST- 2023/04/23 00:00 [received] PHST- 2023/11/07 00:00 [accepted] PHST- 2024/07/31 12:44 [medline] PHST- 2024/07/31 12:43 [pubmed] PHST- 2024/07/31 07:44 [entrez] PHST- 2024/07/10 00:00 [pmc-release] AID - S0034-89102024000100223 [pii] AID - 10.11606/s1518-8787.2024058005505 [doi] PST - epublish SO - Rev Saude Publica. 2024 Jul 26;58:28. doi: 10.11606/s1518-8787.2024058005505. eCollection 2024. PMID- 39080362 OWN - NLM STAT- MEDLINE DCOM- 20240731 LR - 20240909 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Jul 30 TI - Examining the association between the FTO gene and neuroticism reveals indirect effects on subjective well-being and problematic alcohol use. PG - 17566 LID - 10.1038/s41598-024-68578-2 [doi] LID - 17566 AB - Associations between the fat mass and obesity-associated (FTO) gene and obesity are well-established. However, recent studies have linked FTO to addiction phenotypes and dopaminergic signaling, thus suggesting broader psychiatric implications. We explored this assumption by conducting a phenome-wide association study across 4756 genome-wide association studies, identifying 23-26 psychiatric traits associated with FTO at the multiple-corrected significance level. These traits clustered into four categories: substance use, chronotype/sleep, well-being, and neuroticism. To validate these findings, we analyzed a functionally suggestive FTO variant (rs1421085) in a separate cohort, examining its impact on (i) alcohol use based on the Alcohol Use Disorders Identification Test (AUDIT), (ii) subjective well-being based on the WHO (Ten) Well-Being Index, and (iii) neuroticism based on Schafer's Five Factor Model or the Karolinska Scales of Personality. Our results confirmed a direct association between rs1421085 and neuroticism that was independent of age, sex, alcohol use, body mass index (BMI), and childhood adversities. Interestingly, while no direct association with alcohol intake was observed, both cross-sectional and lagged longitudinal mediation analyses uncovered indirect relationships between rs1421085 and problematic alcohol use (AUDIT-P), with increased neuroticism acting as the intermediary. Mediation analyses also supported an indirect effect of rs1421085 on lower well-being through the pathways of increased neuroticism and BMI. Our study is the first to validate a direct association between FTO and neuroticism. However, additional studies are warranted to affirm the causal pathways linking FTO to well-being and alcohol use through neuroticism. CI - (c) 2024. The Author(s). FAU - Cai, Wenjie AU - Cai W AD - Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176, Stockholm, Sweden. AD - Center for Molecular Medicine, L8:00, Karolinska University Hospital, 17176, Stockholm, Sweden. FAU - Forsell, Yvonne AU - Forsell Y AD - Department of Global Public Health, Karolinska Institutet, 17177, Stockholm, Sweden. FAU - Lavebratt, Catharina AU - Lavebratt C AD - Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176, Stockholm, Sweden. AD - Center for Molecular Medicine, L8:00, Karolinska University Hospital, 17176, Stockholm, Sweden. FAU - Melas, Philippe A AU - Melas PA AD - Center for Molecular Medicine, L8:00, Karolinska University Hospital, 17176, Stockholm, Sweden. Philippe.Melas@ki.se. AD - Center for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, 11364, Stockholm, Sweden. Philippe.Melas@ki.se. LA - eng GR - 2023-0335/Swedish Brain Foundation/ GR - FO2023-0167/Swedish Brain Foundation/ GR - RS2021-0855, SLL20190589/the regional agreement on medical training and clinical research (ALF) between Stockholm County Council and Karolinska Institutet Stockholm County Council/ GR - 2022-1188/Vetenskapsradet/ GR - 2023-02253/Vetenskapsradet/ GR - 42797/Kungliga Fysiografiska Sallskapet i Lund/ GR - M21-0092, M22-0059/Ake Wiberg Stiftelse/ GR - 2021-04173, 2022-038/Magnus Bergvalls Stiftelse/ GR - LA2021-0124, LA2022-0139/Sigurd and Elsa Golje Memorial Foundation/ GR - 2022-01667/Karolinska Institutet Research Grants/ GR - FO2023-0046/the Alcohol Research Council of the Swedish Alcohol Retailing Monopoly/ PT - Journal Article DEP - 20240730 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - EC 1.14.11.33 (Alpha-Ketoglutarate-Dependent Dioxygenase FTO) RN - EC 1.14.11.33 (FTO protein, human) SB - IM MH - Humans MH - *Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics MH - *Neuroticism MH - Male MH - Female MH - Adult MH - *Genome-Wide Association Study MH - Middle Aged MH - Polymorphism, Single Nucleotide MH - Alcoholism/genetics MH - Alcohol Drinking/genetics MH - Body Mass Index MH - Genetic Predisposition to Disease PMC - PMC11289395 OTO - NOTNLM OT - ALKBH9 OT - AUD OT - Alcohol use disorder OT - Alcoholism OT - Alpha-ketoglutarate-dependent dioxygenase FTO OT - Big five personality traits OT - Fat mass and obesity-associated gene COIS- The authors declare no competing interests. EDAT- 2024/07/31 00:41 MHDA- 2024/07/31 06:42 PMCR- 2024/07/30 CRDT- 2024/07/30 23:37 PHST- 2023/12/01 00:00 [received] PHST- 2024/07/25 00:00 [accepted] PHST- 2024/07/31 06:42 [medline] PHST- 2024/07/31 00:41 [pubmed] PHST- 2024/07/30 23:37 [entrez] PHST- 2024/07/30 00:00 [pmc-release] AID - 10.1038/s41598-024-68578-2 [pii] AID - 68578 [pii] AID - 10.1038/s41598-024-68578-2 [doi] PST - epublish SO - Sci Rep. 2024 Jul 30;14(1):17566. doi: 10.1038/s41598-024-68578-2. PMID- 39076045 OWN - NLM STAT- MEDLINE DCOM- 20241104 LR - 20241104 IS - 1528-1167 (Electronic) IS - 0013-9580 (Linking) VI - 65 IP - 9 DP - 2024 Sep TI - Automated detection of tonic seizures using wearable movement sensor and artificial neural network. PG - e170-e174 LID - 10.1111/epi.18077 [doi] AB - Although several validated wearable devices are available for detection of generalized tonic-clonic seizures, automated detection of tonic seizures is still a challenge. In this phase 1 study, we report development and validation of an artificial neural network (ANN) model for automated detection of tonic seizures with visible clinical manifestation using a wearable wristband movement sensor (accelerometer and gyroscope). The dataset prospectively recorded for this study included 70 tonic seizures from 15 patients (seven males, age 3-46 years, median = 19 years). We trained an ANN model to detect tonic seizures. The independent test dataset comprised nocturnal recordings, including 10 tonic seizures from three patients and additional (distractor) data from three subjects without seizures. The ANN model detected nocturnal tonic seizures with visible clinical manifestation with a sensitivity of 100% (95% confidence interval = 69%-100%) and with an average false alarm rate of .16/night. The mean detection latency was 14.1 s (median = 10 s), with a maximum of 47 s. These data suggest that nocturnal tonic seizures can be reliably detected with movement sensors using ANN. Large-scale, multicenter prospective (phase 3) trials are needed to provide compelling evidence for the clinical utility of this device and detection algorithm. CI - (c) 2024 The Author(s). Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy. FAU - Larsen, Sidsel Armand AU - Larsen SA AD - Department of Clinical Neurophysiology, Danish Epilepsy Center, Dianalund, Denmark. AD - Department of Clinical Medicine, Aarhus University and Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark. FAU - Johansen, Daniel Hojrup AU - Johansen DH AD - Danish Care Technology, Soro, Denmark. FAU - Beniczky, Sandor AU - Beniczky S AUID- ORCID: 0000-0002-6035-6581 AD - Department of Clinical Neurophysiology, Danish Epilepsy Center, Dianalund, Denmark. AD - Department of Clinical Medicine, Aarhus University and Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark. LA - eng PT - Journal Article DEP - 20240730 PL - United States TA - Epilepsia JT - Epilepsia JID - 2983306R SB - IM MH - Humans MH - *Neural Networks, Computer MH - Male MH - Adult MH - *Wearable Electronic Devices MH - Female MH - Young Adult MH - Middle Aged MH - *Seizures/diagnosis/physiopathology MH - Adolescent MH - Child, Preschool MH - Child MH - Electroencephalography/instrumentation/methods MH - Movement/physiology MH - Accelerometry/instrumentation/methods MH - Prospective Studies OTO - NOTNLM OT - artificial intelligence OT - automated seizure detection OT - tonic seizures OT - wristband sensor EDAT- 2024/07/30 06:42 MHDA- 2024/11/04 22:24 CRDT- 2024/07/30 03:43 PHST- 2024/07/09 00:00 [revised] PHST- 2023/12/12 00:00 [received] PHST- 2024/07/17 00:00 [accepted] PHST- 2024/11/04 22:24 [medline] PHST- 2024/07/30 06:42 [pubmed] PHST- 2024/07/30 03:43 [entrez] AID - 10.1111/epi.18077 [doi] PST - ppublish SO - Epilepsia. 2024 Sep;65(9):e170-e174. doi: 10.1111/epi.18077. Epub 2024 Jul 30. PMID- 39074616 OWN - NLM STAT- MEDLINE DCOM- 20240909 LR - 20260529 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 202 DP - 2024 Nov 1 TI - Design and validation of a photographic atlas of Peruvian foods to evaluate the food consumption of children from 6 to 12 months of age. PG - 107611 LID - S0195-6663(24)00414-8 [pii] LID - 10.1016/j.appet.2024.107611 [doi] AB - OBJECTIVE: Design and validation a photographic atlas of Peruvian foods to evaluate the food consumption of children from 6 to 12 months of age. METHODS: Quantitative, descriptive, and cross-sectional study. 12 food groups were established according to their nutrient content. The atlas is designed to be applied to mothers, fathers, or caregivers of children from 6 to 12 months of age. The methodology was divided into four stages: i) selection of the food list, regional recipe books from Peru were reviewed, then interviews with mothers of children in the age range were verified for the final selection of the food list; ii) preparation and weighing of food, utensils were used to establish home measurements and with the established weight the macro and micronutrients were calculated with tables of composition of Peruvian foods; iii) development of the photographic session, a professional photographer with previous experience in similar works was used; and iv) expert validation, with the participation of 5 nutritionists with experience in infant feeding. RESULTS: The proposed atlas includes 57 foods with a total of 91 photographs. The content validity coefficient according to food category and in total obtained an assessment of 0.75 (Cohen's kappa coefficient), which gives it acceptable validity and agreement. CONCLUSIONS: The photographic atlas of food portions for infant feeding in Peru is a practical, reliable, and culturally appropriate visual tool to help estimate the amount of food consumed by this population, which will facilitate the estimation of food intake. CI - Copyright (c) 2024. Published by Elsevier Ltd. FAU - Mamani-Urrutia, Victor AU - Mamani-Urrutia V AD - Universidad Cientifica del Sur, Lima, Peru. Electronic address: vmamaniu@cientifica.edu.pe. FAU - Duran-Galdo, Rafael AU - Duran-Galdo R AD - Department of Global Public Health and Primary Care and Centre for International Health, University of Bergen, Norway. FAU - Salvatierra-Ruiz, Rosa AU - Salvatierra-Ruiz R AD - Instituto Nacional de Salud, Lima, Peru. FAU - Rivera-Medina, Juan AU - Rivera-Medina J AD - Department of Medicine, Instituto Nacional de Salud del Nino, Lima, Peru; Department of Paediatrics, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru. FAU - Delgado, Carlos AU - Delgado C AD - Department of Medicine, Instituto Nacional de Salud del Nino, Lima, Peru; Department of Paediatrics, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru. FAU - Montag, Doreen AU - Montag D AD - Wolfson Institute of Population Health, Queen Mary University of London, UK. Electronic address: d.montag@qmul.ac.uk. LA - eng PT - Journal Article PT - Review PT - Validation Study DEP - 20240727 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Peru MH - Infant MH - *Photography MH - Cross-Sectional Studies MH - Female MH - Male MH - Atlases as Topic MH - Infant Nutritional Physiological Phenomena MH - Feeding Behavior MH - Diet/statistics & numerical data MH - Reproducibility of Results MH - Infant Food/statistics & numerical data MH - Nutritive Value OTO - NOTNLM OT - Atlas OT - Infant nutrition OT - Nutrition surveys OT - Peru OT - Photograph COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/07/30 00:42 MHDA- 2024/09/10 00:43 CRDT- 2024/07/29 19:13 PHST- 2024/01/18 00:00 [received] PHST- 2024/07/22 00:00 [revised] PHST- 2024/07/23 00:00 [accepted] PHST- 2024/09/10 00:43 [medline] PHST- 2024/07/30 00:42 [pubmed] PHST- 2024/07/29 19:13 [entrez] AID - S0195-6663(24)00414-8 [pii] AID - 10.1016/j.appet.2024.107611 [doi] PST - ppublish SO - Appetite. 2024 Nov 1;202:107611. doi: 10.1016/j.appet.2024.107611. Epub 2024 Jul 27. PMID- 39070955 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240730 IS - 2772-8129 (Electronic) IS - 2772-8129 (Linking) VI - 3 IP - 3 DP - 2024 Jun TI - Childhood Maltreatment and Body Mass Index in Older Adults With Chronic Illness. PG - 87-97 LID - 10.1016/j.cjcpc.2024.03.002 [doi] AB - BACKGROUND: Childhood trauma has been associated with greater psychological and physical morbidity, including a greater risk of developing coronary artery disease (CAD). Emotional dysregulation and increased body mass index (BMI) may be involved. This study evaluated whether (1) childhood maltreatment is associated with a higher BMI at study onset and with greater increases in BMI 5 years later among older adults with CAD or other chronic illnesses; (2) sex and/or CAD status moderate these results; and (3) baseline symptoms of anxiety, depression, and perceived stress (emotional dysregulation) mediate the association between childhood maltreatment and BMI at follow-up. METHODS: A total of 1232 men and women (aged 60.86 [6.95] years) completed validated questionnaires on childhood maltreatment and symptoms of psychological distress. The weight and height of the participant were measured, and the BMI was calculated using the weight (kg)/height (m(2)) ratio. RESULTS: Childhood maltreatment was not significantly associated with BMI at study onset nor at follow-up. This relation did not differ as a function of sex nor CAD status. Although childhood maltreatment was associated with significantly greater psychological distress at study onset (all P < 0.001), there latter was not found to mediate the relation between maltreatment and change in BMI at follow-up. CONCLUSIONS: In contrast to previous literature, childhood maltreatment was not associated with BMI nor with the change in BMI over 5 years in men and women with chronic disease. However, as psychological distress increases risk for morbidity and mortality, it may represent an important target for prevention and intervention in survivors of childhood maltreatment. CI - (c) 2024 The Author(s). FAU - St-Arnaud, Vicki AU - St-Arnaud V AD - Research Centre, Montreal Heart Institute, Montreal, Quebec, Canada. AD - Psychology Department, Universite de Montreal, Montreal, Quebec, Canada. FAU - Chicoine, Ann Xiuli AU - Chicoine AX AD - Research Centre, Montreal Heart Institute, Montreal, Quebec, Canada. AD - Psychology Department, Universite de Montreal, Montreal, Quebec, Canada. FAU - Tardif, Jean-Claude AU - Tardif JC AD - Research Centre, Montreal Heart Institute, Montreal, Quebec, Canada. AD - Department of Medicine, Universite de Montreal, Montreal, Quebec, Canada. FAU - Busseuil, David AU - Busseuil D AD - Research Centre, Montreal Heart Institute, Montreal, Quebec, Canada. FAU - D'Antono, Bianca AU - D'Antono B AD - Research Centre, Montreal Heart Institute, Montreal, Quebec, Canada. AD - Psychology Department, Universite de Montreal, Montreal, Quebec, Canada. LA - eng PT - Journal Article DEP - 20240403 PL - United States TA - CJC Pediatr Congenit Heart Dis JT - CJC pediatric and congenital heart disease JID - 9918697364606676 PMC - PMC11282884 EDAT- 2024/07/29 06:42 MHDA- 2024/07/29 06:43 PMCR- 2024/04/03 CRDT- 2024/07/29 05:37 PHST- 2024/01/17 00:00 [received] PHST- 2024/03/06 00:00 [accepted] PHST- 2024/07/29 06:43 [medline] PHST- 2024/07/29 06:42 [pubmed] PHST- 2024/07/29 05:37 [entrez] PHST- 2024/04/03 00:00 [pmc-release] AID - S2772-8129(24)00037-X [pii] AID - 10.1016/j.cjcpc.2024.03.002 [doi] PST - epublish SO - CJC Pediatr Congenit Heart Dis. 2024 Apr 3;3(3):87-97. doi: 10.1016/j.cjcpc.2024.03.002. eCollection 2024 Jun. PMID- 39070077 OWN - NLM STAT- MEDLINE DCOM- 20240729 LR - 20260513 IS - 2214-9996 (Electronic) IS - 2214-9996 (Linking) VI - 90 IP - 1 DP - 2024 TI - Infant Feeding Practices, Prevalence of Adolescent Motherhood and Malnutrition among Infants in Mangu Local Government Area, Plateau State, Nigeria. PG - 44 LID - 10.5334/aogh.4229 [doi] LID - 44 AB - Background: Adolescent motherhood and malnutrition among children are significant challenges in Africa, but there is limited data on the impact of adolescent motherhood on their children's health and nutrition. This study assessed infant feeding practices, prevalence of adolescent motherhood, and malnutrition among infants in Mangu local government area (LGA). Methodology: A cross-sectional survey using multistage sampling was conducted. Validated questionnaires were used to collect socio-demographic data, and appropriate tools were used for anthropometric measurements. Data were compared with established standards. Descriptive statistical tools, chi square, Pearson correlation, and independent sample t-test were used for data analysis, with significance set at p < 0.05. Results: A total of 200 mothers completed the study. The majority of the infants (78.5%) were less than 6 months old, and 21.5% were 6-12 months old. Breastfeeding initiation within 1 hour was reported by 39% of mothers, while 38% practiced prelacteal feeding. Only 28.5% practiced exclusive breastfeeding, and all mothers breastfed their babies. The prevalence of adolescent motherhood was 37.5%. The prevalence of stunting, wasting, and underweight among infants were 29.5%, 12%, and 8.5%, respectively. Children of adolescent mothers had higher rates of severe stunting compared to children of mothers above 19 years of age. There were significant differences (p = 0.017 and p = 0.029) in stunting rates and weight-for-age indices between children of adolescent mothers and mothers above 19 years of age. Conclusion: Adolescent motherhood contributes to chronic malnutrition in children, and there is a high prevalence of malnutrition among infants in Mangu LGA, Plateau State. CI - Copyright: (c) 2024 The Author(s). FAU - Maduforo, Aloysius N AU - Maduforo AN AUID- ORCID: 0000-0001-7290-5632 AD - Department of Nutrition and Dietetics, University of Nigeria, Nsukka, Nigeria. AD - Department of Educational Research (Leadership), Werklund School of Education, University of Calgary, Alberta, Canada. FAU - Okoro, Clementina E AU - Okoro CE AD - Department of Nutrition and Dietetics, University of Nigeria, Nsukka, Nigeria. AD - Nutrition Section, Federal Capital Territory Primary Health Care Board, Abuja, Nigeria. FAU - Chikwendu, Justina N AU - Chikwendu JN AUID- ORCID: 0000-0003-4005-8613 AD - Department of Nutrition and Dietetics, University of Nigeria, Nsukka, Nigeria. FAU - Ndiokwelu, Chika AU - Ndiokwelu C AUID- ORCID: 0000-0001-9869-970X AD - Department of Human Nutrition and Dietetics, University of Calabar, Nigeria. FAU - Asogwa, Gift AU - Asogwa G AD - Department of Nutrition and Dietetics, University of Nigeria, Nsukka, Nigeria. FAU - Aloysius-Maduforo, Miracle C AU - Aloysius-Maduforo MC AUID- ORCID: 0009-0000-0687-0232 AD - Department of Educational Research (Learning Sciences), Werklund School of Education, University of Calgary, Alberta, Canada. FAU - Okwara, Chinyere C AU - Okwara CC AD - Department of Nutrition and Dietetics, University of Nigeria Teaching Hospital Ituku-Ozalla, Enugu State, Nigeria. FAU - Okorie, Josephine Nwanneoma AU - Okorie JN AUID- ORCID: 0009-0008-0108-4476 AD - Niger State Polytechnic, Zungeru, Niger State, Nigeria. AD - School of Community Health and Policy, Morgan State University, Maryland, United States. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240719 PL - United States TA - Ann Glob Health JT - Annals of global health JID - 101620864 SB - IM MH - Humans MH - Infant MH - Adolescent MH - Female MH - Nigeria/epidemiology MH - Cross-Sectional Studies MH - *Breast Feeding/statistics & numerical data MH - Prevalence MH - *Thinness/epidemiology MH - Young Adult MH - Male MH - Pregnancy in Adolescence/statistics & numerical data MH - Growth Disorders/epidemiology MH - Adult MH - Wasting Syndrome/epidemiology MH - Mothers MH - Infant Nutrition Disorders/epidemiology MH - Malnutrition/epidemiology MH - Infant, Newborn MH - Local Government MH - Pregnancy MH - Surveys and Questionnaires PMC - PMC11276407 OTO - NOTNLM OT - Adolescent motherhood OT - IYCF OT - infants OT - malnutrition COIS- The authors have no competing interests to declare. EDAT- 2024/07/29 06:42 MHDA- 2024/07/29 06:43 PMCR- 2024/07/19 CRDT- 2024/07/29 05:26 PHST- 2023/06/30 00:00 [received] PHST- 2024/06/24 00:00 [accepted] PHST- 2024/07/29 06:43 [medline] PHST- 2024/07/29 06:42 [pubmed] PHST- 2024/07/29 05:26 [entrez] PHST- 2024/07/19 00:00 [pmc-release] AID - 10.5334/aogh.4229 [doi] PST - epublish SO - Ann Glob Health. 2024 Jul 19;90(1):44. doi: 10.5334/aogh.4229. eCollection 2024. PMID- 39069538 OWN - NLM STAT- MEDLINE DCOM- 20250423 LR - 20260823 IS - 1530-0447 (Electronic) IS - 0031-3998 (Print) IS - 0031-3998 (Linking) VI - 96 IP - 7 DP - 2024 Dec TI - Establishing feasibility and reliability of subcutaneous fat measurements by ultrasound in very preterm infants. PG - 1724-1731 LID - 10.1038/s41390-024-03439-2 [doi] AB - BACKGROUND: Regional fat distribution may be a marker of metabolic health and brain growth in preterm infants. Point of care ultrasound has been used to assess regional fat in term infants but has not been used widely in preterm infants. OBJECTIVE: To longitudinally quantify changes in body composition metrics using bedside ultrasound in very preterm infants. STUDY DESIGN: Very preterm infants (N = 69) were enrolled after birth and body composition assessments were done through 36 completed weeks' postmenstrual age (PMA). Linear mixed effects regression was used to model change in body composition assessments over time. RESULTS: There was an average increase across PMA for each body composition outcome. Biceps ultrasound subcutaneous fat (SQF) thickness increased by 0.11 mm (95% CI: 0.09, 0.13) each postmenstrual week. Triceps, subscapular, and abdominal ultrasound SQF remained constant through 28 weeks' PMA, then increased each week through 36 completed weeks' PMA. The inter-rater and intra-rater intraclass correlation coefficients for the ultrasound SQF measures ranged from 85.8 to 99.9. CONCLUSION: Use of ultrasound as a novel method to assess regional fat distribution in very preterm infants is feasible and reliable. IMPACT: Regional fat distribution may be a marker of metabolic health and brain growth in preterm infants. Gold standard body composition assessments may not be feasible in medically fragile very preterm infants. This study assesses longitudinally changes in regional adiposity development using bedside ultrasound techniques in a multicenter cohort of very preterm infants. Results of this study show that bedside ultrasound as a novel method to assess regional subcutaneous fat distribution and development in very preterm infants is both feasible and reliable. CI - (c) 2024. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - Buck, Catherine O AU - Buck CO AD - Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA. Catherine.buck@yale.edu. FAU - Santoro, Kristin L AU - Santoro KL AD - Department of Neonatology, Beth Israel Deaconess Medical Center; Harvard Medical School, Boston, MA, USA. FAU - Shabanova, Veronika AU - Shabanova V AD - Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA. FAU - Martin, Camilia R AU - Martin CR AD - Division of Neonatology, Weill Cornell Medicine, New York, NY, USA. FAU - Taylor, Sarah N AU - Taylor SN AD - Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA. LA - eng GR - K23 HD104907/HD/NICHD NIH HHS/United States GR - R01 HD106359/HD/NICHD NIH HHS/United States GR - T32 HD098061/HD/NICHD NIH HHS/United States GR - UL1 TR001863/TR/NCATS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20240728 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM MH - Humans MH - Infant, Newborn MH - *Subcutaneous Fat/diagnostic imaging MH - Ultrasonography MH - Feasibility Studies MH - Female MH - Male MH - Reproducibility of Results MH - Body Composition MH - Infant, Premature MH - Longitudinal Studies MH - Gestational Age MH - Infant, Extremely Premature PMC - PMC11772127 MID - NIHMS2013228 COIS- Competing interests: The authors declare no competing interests. Ethics approval: This study was performed in accordance with the declaration of Helinski and was approved by the Institutional Review Boards at Beth Israel Deaconess Medical Center and Yale University. EDAT- 2024/07/29 00:42 MHDA- 2025/01/28 00:21 PMCR- 2025/06/01 CRDT- 2024/07/28 23:05 PHST- 2024/03/13 00:00 [received] PHST- 2024/07/13 00:00 [accepted] PHST- 2024/05/23 00:00 [revised] PHST- 2025/01/28 00:21 [medline] PHST- 2024/07/29 00:42 [pubmed] PHST- 2024/07/28 23:05 [entrez] PHST- 2025/06/01 00:00 [pmc-release] AID - 10.1038/s41390-024-03439-2 [pii] AID - 10.1038/s41390-024-03439-2 [doi] PST - ppublish SO - Pediatr Res. 2024 Dec;96(7):1724-1731. doi: 10.1038/s41390-024-03439-2. Epub 2024 Jul 28. PMID- 39068686 OWN - NLM STAT- MEDLINE DCOM- 20240903 LR - 20240904 IS - 2468-7812 (Electronic) IS - 2468-7812 (Linking) VI - 73 DP - 2024 Oct TI - Item generation for a new patient-reported outcome measure: The non-traumatic anterior knee pain (AKP)-YOUTH scale. PG - 103151 LID - S2468-7812(24)00246-7 [pii] LID - 10.1016/j.msksp.2024.103151 [doi] AB - BACKGROUND: Non-traumatic anterior knee pain affects one in every five adolescents. Despite the commonality of the condition, there are no patient-reported outcome measures developed specifically for this population. The aim of this study was to identify domains and develop a preliminary item bank for adolescents with non-traumatic anterior knee pain. PARTICIPANTS: Twenty-one adolescents with anterior knee pain participated in semi-structured interviews which explored their experience of living with knee pain. Following thematic analysis, we generated an item bank based on the domains which emerged from the impact their knee pain had on their daily life. Ten clinical experts provided input on the preliminary item bank via an online survey. Cognitive interviews were conducted using the think-aloud approach with ten adolescents to evaluate the comprehensibility and face validity of the items. RESULTS: From the interviews we identified four overarching domains where adolescents were impacted by their knee pain: knee symptoms, limitations in physical activity/sport, limitations in social activities, and emotional impact of pain. Eighteen items were initially developed and expanded to 23 following clinical expert input. The cognitive interviews with adolescents demonstrated that the items were comprehensive, understandable, and relevant for adolescents. CONCLUSION: This study developed an item bank of 23 items. These spanned four domains of impact for adolescents with anterior knee pain. The items had good face validity and were deemed relevant and understandable for adolescents with knee pain. Further steps are needed to validate and reduce the items for the non-traumatic anterior knee pain (AKP)-YOUTH scale. CI - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Nielsen, Marie Germund AU - Nielsen MG AD - Clinical Nursing Research Unit, Aalborg University Hospital, Aalborg, Denmark; Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark. Electronic address: marie.nielsen@rn.dk. FAU - Lyng, Kristian Damgaard AU - Lyng KD AD - Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark; Center for General Practice at Aalborg University, Aalborg, Denmark. Electronic address: klyng@dcm.aau.dk. FAU - Holden, Sinead AU - Holden S AD - Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark; Center for General Practice at Aalborg University, Aalborg, Denmark; School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland. Electronic address: siho@hst.aau.dk. FAU - Johansen, Simon Kristoffer AU - Johansen SK AD - Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark; Center for General Practice at Aalborg University, Aalborg, Denmark. Electronic address: skjohansen@dcm.aau.dk. FAU - Winters, Marinus AU - Winters M AD - Center for General Practice at Aalborg University, Aalborg, Denmark. Electronic address: marinuswinters@hotmail.com. FAU - Rathleff, Michael Skovdal AU - Rathleff MS AD - Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark; Center for General Practice at Aalborg University, Aalborg, Denmark; Department of Occupational Therapy and Physiotherapy, Aalborg University Hospital, Aalborg, Denmark. Electronic address: misr@hst.aau.dk. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240723 PL - Netherlands TA - Musculoskelet Sci Pract JT - Musculoskeletal science & practice JID - 101692753 SB - IM MH - Humans MH - Male MH - Female MH - *Patient Reported Outcome Measures MH - Adolescent MH - Pain Measurement MH - Surveys and Questionnaires MH - Knee Joint/physiopathology MH - Reproducibility of Results MH - Psychometrics OTO - NOTNLM OT - Adolescents OT - Knee pain OT - Patient reported outcome measure COIS- Declaration of competing interest None stated. EDAT- 2024/07/28 18:44 MHDA- 2024/09/04 01:01 CRDT- 2024/07/28 18:00 PHST- 2024/01/06 00:00 [received] PHST- 2024/07/10 00:00 [revised] PHST- 2024/07/22 00:00 [accepted] PHST- 2024/09/04 01:01 [medline] PHST- 2024/07/28 18:44 [pubmed] PHST- 2024/07/28 18:00 [entrez] AID - S2468-7812(24)00246-7 [pii] AID - 10.1016/j.msksp.2024.103151 [doi] PST - ppublish SO - Musculoskelet Sci Pract. 2024 Oct;73:103151. doi: 10.1016/j.msksp.2024.103151. Epub 2024 Jul 23. PMID- 39065833 OWN - NLM STAT- MEDLINE DCOM- 20240728 LR - 20240729 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 24 IP - 14 DP - 2024 Jul 9 TI - Accelerometer Thresholds for Estimating Physical Activity Intensity Levels in Infants: A Preliminary Study. LID - 10.3390/s24144436 [doi] LID - 4436 AB - Lack of physical activity (PA) at a young age can result in health issues. Thus, monitoring PA is important. Wearable accelerometers are the preferred tool to monitor PA in children. Validated thresholds are used to classify activity intensity levels, e.g., sedentary, light, and moderate-to-vigorous, in ambulatory children. No previous work has developed accelerometer thresholds for infancy (pre-ambulatory children). Therefore, this work aims to develop accelerometer thresholds for PA intensity levels in pre-ambulatory infants. Infants (n = 10) were placed in a supine position and allowed free movement. Their movements were synchronously captured using video cameras and accelerometers worn on each ankle. The video data were labeled by activity intensity level (sedentary, light, and moderate-to-vigorous) in two-second epochs using observational rating (gold standard). Accelerometer thresholds were developed for acceleration and jerk using two optimization approaches. Four sets of thresholds were developed for dual (two ankles) and for single-worn (one ankle) accelerometers. Of these, for a typical use case, we recommend using acceleration-based thresholds of 1.00 m/s to distinguish sedentary and light activity and 2.60 m/s to distinguish light and moderate-to-vigorous activity. Acceleration and jerk are both suitable for measuring PA. FAU - Ghazi, Mustafa A AU - Ghazi MA AUID- ORCID: 0009-0004-6415-4671 AD - Division of Developmental-Behavioral Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA. FAU - Zhou, Judy AU - Zhou J AD - Division of Biokinesiology and Physical Therapy, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90089, USA. FAU - Havens, Kathryn L AU - Havens KL AD - Division of Biokinesiology and Physical Therapy, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90089, USA. FAU - Smith, Beth A AU - Smith BA AD - Division of Developmental-Behavioral Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA. AD - Developmental Neuroscience and Neurogenetics Program, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA. AD - Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. LA - eng GR - X/CAL-PT FUND/ GR - X/American Physical Therapy Association Academy of Pediatric Physical Therapy/ PT - Journal Article DEP - 20240709 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - *Accelerometry/instrumentation/methods MH - Infant MH - *Exercise/physiology MH - Male MH - Female MH - Wearable Electronic Devices PMC - PMC11280506 OTO - NOTNLM OT - infant OT - physical activity intensity OT - threshold OT - validation OT - wearable accelerometer COIS- We have no conflicts of interest to disclose. EDAT- 2024/07/27 10:46 MHDA- 2024/07/28 14:51 PMCR- 2024/07/09 CRDT- 2024/07/27 01:28 PHST- 2024/04/29 00:00 [received] PHST- 2024/06/18 00:00 [revised] PHST- 2024/07/06 00:00 [accepted] PHST- 2024/07/28 14:51 [medline] PHST- 2024/07/27 10:46 [pubmed] PHST- 2024/07/27 01:28 [entrez] PHST- 2024/07/09 00:00 [pmc-release] AID - s24144436 [pii] AID - sensors-24-04436 [pii] AID - 10.3390/s24144436 [doi] PST - epublish SO - Sensors (Basel). 2024 Jul 9;24(14):4436. doi: 10.3390/s24144436. PMID- 39064782 OWN - NLM STAT- MEDLINE DCOM- 20240728 LR - 20240729 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 14 DP - 2024 Jul 19 TI - Adherence to a Healthy Diet and Risk of Multiple Carotid Atherosclerosis Subtypes: Insights from the China MJ Health Check-Up Cohort. LID - 10.3390/nu16142338 [doi] LID - 2338 AB - AIM: Early-stage phenotypes of carotid atherosclerosis (CAS), such as increased carotid intima-media thickness (cIMT), and advanced-stage phenotypes, such as carotid plaque (CP), are at risk for adverse ischemic stroke events. There is limited evidence regarding the causal association between dietary patterns and the risk of CAS in Chinese adults. We therefore examined multiple dietary patterns associated with the risk of CAS and identified the optimal dietary pattern for preventing CAS. METHODS: We analyzed data collected from the prospective MJ Health Check-up Study (2004-2020), including 13,989 participants 18-80 years of age without CAS. The dietary intake was measured using validated food frequency questionnaires, and dietary pattern scores were calculated for four a priori and four a posteriori dietary patterns. The Cox model was used to estimate the adjusted hazard ratios (HRs) relating various dietary pattern scores to the risk of CAS. RESULTS: During 43,903.4 person-years of follow-up, 3732 incidents of increased cIMT and 2861 incident CP events were documented. Overall, the seven dietary patterns, except for the high-protein diet, exhibited significant associations with the risk of increased cIMT and CP. Comparing the highest and lowest quartiles, the a posteriori high-fiber dietary pattern (HFIDP) score demonstrated the strongest inverse associations with the risk of increased cIMT (HR 0.65 [95% confidence interval (CI) 0.59-0.71]) and CP (HR 0.65 [95% CI 0.59-0.73]); conversely, another a posteriori high-fat dietary pattern (HFADP; i.e., incorporating high-fat and processed foods) demonstrated the strongest positive associations with the risk of increased cIMT (HR 1.96 [95% CI 1.75-2.20]) and CP (HR 1.83 [95% CI 1.61-2.08]) (all p for trend < 0.01). CONCLUSIONS: Multiple dietary patterns are significantly associated with the risk of early- and advanced-stage phenotypes of CAS. Notably, a high adherence to an HFIDP and low adherence to an HFADP may confer the greatest risk reduction for CAS. FAU - Fu, Jingzhu AU - Fu J AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. AD - Peking University Health Science Center, Meinian Public Health Institute, Beijing 100191, China. AD - Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing 100191, China. FAU - Deng, Yuhan AU - Deng Y AD - Meinian Institute of Health, Beijing 100083, China. AD - Department of Social Medicine and Health Education, School of Public Health, Peking University, Beijing 100191, China. AD - Chongqing Research Institute of Big Data, Peking University, Chongqing 400000, China. FAU - Ma, Yuan AU - Ma Y AD - Meinian Institute of Health, Beijing 100083, China. AD - School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China. FAU - Man, Sailimai AU - Man S AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. AD - Peking University Health Science Center, Meinian Public Health Institute, Beijing 100191, China. AD - Meinian Institute of Health, Beijing 100083, China. FAU - Yang, Xiaochen AU - Yang X AD - Meinian Institute of Health, Beijing 100083, China. AD - Department of Social Medicine and Health Education, School of Public Health, Peking University, Beijing 100191, China. FAU - Yu, Canqing AU - Yu C AUID- ORCID: 0000-0002-0019-0014 AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. AD - Peking University Health Science Center, Meinian Public Health Institute, Beijing 100191, China. AD - Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing 100191, China. AD - Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China. FAU - Lv, Jun AU - Lv J AUID- ORCID: 0000-0001-7916-3870 AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. AD - Peking University Health Science Center, Meinian Public Health Institute, Beijing 100191, China. AD - Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing 100191, China. AD - Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China. FAU - Liu, Hui AU - Liu H AD - Institute of Medical Information, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. FAU - Wang, Bo AU - Wang B AD - Peking University Health Science Center, Meinian Public Health Institute, Beijing 100191, China. AD - Meinian Institute of Health, Beijing 100083, China. FAU - Li, Liming AU - Li L AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. AD - Peking University Health Science Center, Meinian Public Health Institute, Beijing 100191, China. AD - Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing 100191, China. AD - Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China. LA - eng GR - 2020YFC2004703/Ministry of Science and Technology of the People's Republic of China/ GR - 82192901, 82192904, 82192900/National Natural Science Foundation of China/ GR - 2020YFC2003405/Ministry of Science and Technology of the People's Republic of China/ PT - Journal Article DEP - 20240719 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Carotid Artery Diseases/epidemiology/etiology/diagnostic imaging MH - Middle Aged MH - Male MH - Female MH - China/epidemiology MH - Adult MH - Aged MH - *Diet, Healthy/statistics & numerical data MH - *Carotid Intima-Media Thickness MH - Risk Factors MH - Prospective Studies MH - Young Adult MH - Aged, 80 and over MH - Adolescent MH - Cohort Studies MH - Proportional Hazards Models MH - Patient Compliance/statistics & numerical data PMC - PMC11280435 OTO - NOTNLM OT - China OT - carotid atherosclerosis OT - diet OT - nutrition OT - prospective cohort study COIS- The authors declare no conflicts of interest. EDAT- 2024/07/27 10:45 MHDA- 2024/07/28 14:52 PMCR- 2024/07/19 CRDT- 2024/07/27 01:23 PHST- 2024/06/23 00:00 [received] PHST- 2024/07/11 00:00 [revised] PHST- 2024/07/17 00:00 [accepted] PHST- 2024/07/28 14:52 [medline] PHST- 2024/07/27 10:45 [pubmed] PHST- 2024/07/27 01:23 [entrez] PHST- 2024/07/19 00:00 [pmc-release] AID - nu16142338 [pii] AID - nutrients-16-02338 [pii] AID - 10.3390/nu16142338 [doi] PST - epublish SO - Nutrients. 2024 Jul 19;16(14):2338. doi: 10.3390/nu16142338. PMID- 39064780 OWN - NLM STAT- MEDLINE DCOM- 20240728 LR - 20260203 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 14 DP - 2024 Jul 19 TI - Health Belief Model Predicts Likelihood of Eating Nutrient-Rich Foods among U.S. Adults. LID - 10.3390/nu16142335 [doi] LID - 2335 AB - Despite decades of messaging, most Americans still consume excess fats and sugars, but inadequate fiber, potassium, and calcium. Nutrient-rich foods (NRFs) have a high density of favorable nutrients related to calories. Choosing NRFs could lower risk of nutrition-related chronic diseases and aid in their control. We hypothesized that having greater knowledge of NRFs, the presence of a nutrition-related chronic disease or risk factor, and positive Health Belief Model (HBM) views would be predictive of the likelihood of eating NRFs. Through a national online survey panel, 976 adults aged 18-80 completed demographic, health, NRF knowledge, attitudes, and HBM construct questions. Participants were 77% White, 52% women, and 55% had a nutrition-related disease or risk factor. Multivariable HBM scales were generated by theory, principal components, and reliability analysis. NRF knowledge was significantly higher for women, Whites, households without children, and persons without a nutrition-related disease (all p /= 2-year subgroup, growth chart extrapolation and parents' report were the most accurate, followed by height measurement alongside the body with a tape measure. In both groups, body segment extrapolations were poorly predictive and showed mean bias and limits of agreement that varied a lot with age. Most body segment-based techniques presented with frequent measurement difficulties, but children's safety was rarely compromised. The inter-rater reliability of body segment measurement was low in the < 2-year subgroup.Conclusions: To accurately estimate height in hospitalized children, health care professionals should integrate the accuracy, precision, practicability, and reliability of each measurement technique to select the most appropriate one. Body segment-based techniques were the least accurate and should probably not be used. Simple techniques like growth chart extrapolation, or measurement alongside the body (and length board measurement in the youngest) should be implemented in daily practice.Trial Registration: The study protocol was registered (12(th) April 2019) on the clinical-trial.gov website (NCT03913247). CI - (c) 2024. The Author(s). FAU - Ford Chessel, Carole AU - Ford Chessel C AD - Pediatric Dietetic Unit, Hopital Femme Mere Enfant, Hospices Civils de Lyon, 59 Bd Pinel, 69500, Lyon-Bron, France. FAU - Berthiller, Julien AU - Berthiller J AD - Public Health Department, Clinical Epidemiology and Research Unit, Hospices Civils de Lyon, 59 Bd Pinel, 69500, Lyon-Bron, France. FAU - Haran, Isabelle AU - Haran I AD - Pediatric Dietetic Unit, Hopitaux Universitaires de Strasbourg, 1 Avenue Moliere, 67000, Strasbourg, France. FAU - Tume, Lyvonne N AU - Tume LN AUID- ORCID: 0000-0002-2547-8209 AD - Edge Hill University, St Helens Road, Ormskirk, Lancashire, L39 4QP, UK. FAU - Bourgeaud, Christelle AU - Bourgeaud C AD - Pediatric Dietetic Unit, Hopital de La Timone, Assistance Publique Des Hopitaux de Marseille, 264 Rue Saint-Pierre, 13005, Marseille, France. FAU - Tsapis, Michael AU - Tsapis M AD - Pediatric Intensive Care Unit, Assistance Publique Des Hopitaux de Marseille, 264 Rue Saint Pierre, 13385 Cedex 05, Marseille, France. FAU - Gaillard-Le Roux, Benedicte AU - Gaillard-Le Roux B AD - Pediatric Intensive Care Unit, Hopital Femme-Mere-Enfant, Nantes University Hospital, Nantes, France. FAU - Gauvard, Evelyne AU - Gauvard E AD - Clinical Investigation Center, CIC INSERM 1413, Nantes University Hospital, Nantes, France. FAU - Loire, Claire AU - Loire C AD - Pediatric Intensive Care Unit, Hopital Jeanne de Flandre, CHU Lille, Avenue Eugene Avinee, 59000, Lille, France. FAU - Guillot, Camille AU - Guillot C AD - Pediatric Intensive Care Unit, Hopital Jeanne de Flandre, CHU Lille, Avenue Eugene Avinee, 59000, Lille, France. FAU - Mouneydier, Karine AU - Mouneydier K AD - Pediatric Dietetic Department, CHU Bordeaux, Place Amelie Raba-Leon, 33076, Bordeaux Cedex, France. FAU - Nolent, Paul AU - Nolent P AD - Pediatric Intensive Care Unit, CHU Bordeaux, Place Amelie Raba-Leon, 33076, Bordeaux Cedex, France. FAU - Blache, Thibault AU - Blache T AD - Pediatric Cardiac Intensive Care Unit, Hopital Louis Pradel, Hospices Civils de Lyon, 59 Bd Pinel, 69500, Lyon-Bron, France. FAU - Cour Andlauer, Fleur AU - Cour Andlauer F AUID- ORCID: 0000-0002-5551-2500 AD - Pediatric Intensive Care, Hopital Femme Mere Enfant, Hospices Civils de Lyon, 59 Bd Pinel, 69500, Lyon-Bron, France. AD - EA 7426 Joint Research Unit HCL-bioMerieux, 69003, Lyon, France. FAU - Rooze, Shancy AU - Rooze S AD - Pediatric Intensive Care, Hopital Universitaire Reine Fabiola, Avenue JJ Crocq 15, 1020, Laeken, Belgium. FAU - Jotterand Chaparro, Corinne AU - Jotterand Chaparro C AUID- ORCID: 0000-0002-1538-7127 AD - Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland, Geneva, Switzerland. FAU - Morice, Claire AU - Morice C AUID- ORCID: 0009-0000-5774-5562 AD - Pediatric Intensive Care Unit, University Hospital of Geneva, Rue Willy Donze 6, 1205, Geneva, Switzerland. FAU - Subtil, Fabien AU - Subtil F AD - Department of Biostatistics, UMR 5558, CNRS Universite Claude Bernard Lyon 1, Hospices Civils de Lyon, Lyon, France. FAU - Huot, Margaux AU - Huot M AD - Department of Biostatistics, UMR 5558, CNRS Universite Claude Bernard Lyon 1, Hospices Civils de Lyon, Lyon, France. FAU - Valla, Frederic V AU - Valla FV AUID- ORCID: 0000-0001-5285-1104 AD - Pediatric Intensive Care, Hopital Femme Mere Enfant, Hospices Civils de Lyon, 59 Bd Pinel, 69500, Lyon-Bron, France. Frederic.valla@chu-lyon.fr. LA - eng SI - ClinicalTrials.gov/NCT03913247 GR - PHRIP2018/French ministry of health/ PT - Journal Article PT - Multicenter Study DEP - 20240725 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Anthropometry/methods MH - *Body Height MH - *Child, Hospitalized MH - Growth Charts MH - Intensive Care Units, Pediatric MH - Observer Variation MH - Prospective Studies MH - Reproducibility of Results MH - *World Health Organization PMC - PMC11413069 OTO - NOTNLM OT - Anthropometry OT - Critical care OT - Nutritional status OT - Pediatrics COIS- The authors declare no competing interests. EDAT- 2024/07/26 12:41 MHDA- 2024/09/21 13:19 PMCR- 2024/07/25 CRDT- 2024/07/25 11:17 PHST- 2024/03/17 00:00 [received] PHST- 2024/07/15 00:00 [accepted] PHST- 2024/07/09 00:00 [revised] PHST- 2024/09/21 13:19 [medline] PHST- 2024/07/26 12:41 [pubmed] PHST- 2024/07/25 11:17 [entrez] PHST- 2024/07/25 00:00 [pmc-release] AID - 10.1007/s00431-024-05692-3 [pii] AID - 5692 [pii] AID - 10.1007/s00431-024-05692-3 [doi] PST - ppublish SO - Eur J Pediatr. 2024 Oct;183(10):4275-4286. doi: 10.1007/s00431-024-05692-3. Epub 2024 Jul 25. PMID- 39050132 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260923 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 11 DP - 2024 TI - Fresh Moringa Stenopetala leaves consumption and its determinants among pregnant women in southern Ethiopia. PG - 1339819 LID - 10.3389/fnut.2024.1339819 [doi] LID - 1339819 AB - BACKGROUND: A woman's health and nutritional status has significant impact on her pregnancy situation. However, many pregnant women are undernourished. Moringa stenopetala is a plant consumed worldwide in various forms, and its consumption showed a reduction in the incidence of malnutrition. Although Moringa stenopetala is rich in essential macro- and micronutrients, there is little evidence on the proportion and determinants of fresh Moringa stenopetala leaf intake among pregnant women. The objective of this study was to fill this gap in the litterature and provide a baseline evidence for further research or intervention by investigation the proportion and determinants of fresh Moringa stenopetala leaf intake among pregnant women in the Gamo zone, south Ethiopian region. METHODS: A community-based cross-sectional study was conducted among 623 randomly selected pregnant women using a pre-tested and structured questionnaire via a face-to-face interview. The consumption pattern was assessed based on a self-reported dietary history over the last 30 days before data collection. Multivariable logistic regression model was fitted using STATA version 14. An adjusted odds ratio with a 95% confidence interval was reported to show an association between the dependent and independent variables with level of statistical significance at a p-value of <0.05. RESULTS: The proportion of fresh Moringa stenopetala leaves intake among pregnant women was 49.60% (95% CI: 45.67, 53.52%). The determinants of fresh moringa leaf intake were being below 24 years old (AOR: 2.92; 95% CI: 1.51, 5.63), rural residence (AOR: 1.97; 95% CI: 1.10, 3.50), antenatal care attendance (AOR: 2.08; 95% CI: 1.03, 4.21), history of contraceptive use (AOR: 1.88; 95% CI: 1.03, 3.55), and having a good knowledge about the importance of moringa Stenopetala (AOR: 9.76; 95% CI: 5.30, 17.95). CONCLUSION: The study showed that almost half of the pregnant women consumed fresh Moringa stenopetala leaves. Women's age, place of residence, prenatal care, history of contraceptive use, and knowledge of the benefits of Moringa Stenopetala were positively associated with the consumption of fresh Moringa Stenopetala leaves. Therefore, health authorities and stakeholders involved in maternal and child health need to target older women, and urban residents and promote the benefits of consumption by strengthening uptake of maternal health services and raising awareness about Moringa Stenopetela. Future studies involving large scale and longitudinal designs evidence are required to further validate the findings so that this nutritious diet can be promoted widely among pregnant women in the study area and Ethiopia at large. CI - Copyright (c) 2024 Derbo and Debelew. FAU - Derbo, Zeritu Dewana AU - Derbo ZD AD - Department of Midwifery, Arba Minch Health Science College, Arba Minch, Ethiopia. AD - Department of Population and Family Health, Institute of Health, Jimma University, Jimma, Ethiopia. FAU - Debelew, Gurmesa Tura AU - Debelew GT AD - Department of Population and Family Health, Institute of Health, Jimma University, Jimma, Ethiopia. LA - eng PT - Journal Article DEP - 20240710 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC11266132 OTO - NOTNLM OT - Gamo zone OT - Moringa stenopetala OT - consumption OT - pregnant women OT - southern Ethiopia COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/07/26 12:47 MHDA- 2024/07/26 12:48 PMCR- 2024/01/01 CRDT- 2024/07/25 04:48 PHST- 2023/11/16 00:00 [received] PHST- 2024/06/24 00:00 [accepted] PHST- 2024/07/26 12:48 [medline] PHST- 2024/07/26 12:47 [pubmed] PHST- 2024/07/25 04:48 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - 10.3389/fnut.2024.1339819 [doi] PST - epublish SO - Front Nutr. 2024 Jul 10;11:1339819. doi: 10.3389/fnut.2024.1339819. eCollection 2024. PMID- 39049548 OWN - NLM STAT- MEDLINE DCOM- 20241109 LR - 20241109 IS - 1941-2452 (Electronic) IS - 0884-5336 (Linking) VI - 39 IP - 6 DP - 2024 Dec TI - Survey of nutrition screening practices in pediatric hospitals across the United States. PG - 1483-1492 LID - 10.1002/ncp.11193 [doi] AB - BACKGROUND: Nutrition screening on admission is critically important to systematically identify patients with undernutrition given the known relationship with deleterious clinical outcomes. Limited data exist regarding optimal processes and criteria for pediatric nutrition screening. Therefore, we sought to characterize nutrition screening practices in pediatric hospitals. METHODS: A total of 365 inpatient pediatric hospitals in the United States were identified, eligible, and contacted. Eligible hospitals included general pediatric hospitals, adult hospitals with pediatric units, and specialty pediatric hospitals. One respondent at each eligible hospital was asked to complete a 33-question survey of admission nutrition screening practices. RESULTS: Of 268 survey respondents, 37% represented pediatric units in adult hospitals, 35% general pediatric hospitals, and 28% pediatric specialty or psychiatric hospitals. A total of 98.5% endorsed the existence of a screening process on admission. Anthropometrics (eg, body mass index z score, 84%) and nutrition status (eg, change in intake, 67%) were the most common screening criteria applied. A nutrition screening instrument was used in 37% of institutions, and only 31% of institutions reported using pediatric-specific screening instruments. Pediatric units within adult hospitals were 1.38 times more likely to use a screening instrument validated in any population. Barriers to nutrition screening included the lack of a standard screening procedure and insufficient staff to conduct screening. Fifty-four percent of respondents reported a desire to change their hospital's nutrition screening process. CONCLUSION: Most pediatric hospitals screen for nutrition risk on admission. However, methods and criteria varied widely across pediatric hospitals, highlighting the importance of standardized best practices. CI - (c) 2024 American Society for Parenteral and Enteral Nutrition. FAU - Rudie, Coral AU - Rudie C AD - Center for Nutrition, Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Persaud, Sabrina AU - Persaud S AUID- ORCID: 0009-0009-7699-7461 AD - Center for Nutrition, Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA. AD - Clinical Education, Informatics, Quality, and Professional Practice Department, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Hron, Bridget M AU - Hron BM AUID- ORCID: 0000-0002-6482-0150 AD - Center for Nutrition, Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA. AD - Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA. FAU - Raymond, Michelle AU - Raymond M AD - Center for Nutrition, Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Huh, Susanna Y AU - Huh SY AD - Center for Nutrition, Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA. AD - Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA. LA - eng GR - The Payor-Provider Quality Initiative at Boston Children's Hospital supported this project. B.M.H. was also supported by the National Institutes of Health (K23 DK133679) and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) Astra-Zeneca Research Award/ PT - Journal Article DEP - 20240724 PL - United States TA - Nutr Clin Pract JT - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JID - 8606733 SB - IM MH - Humans MH - United States MH - *Hospitals, Pediatric/statistics & numerical data MH - *Nutrition Assessment MH - *Nutritional Status MH - Child MH - *Mass Screening/methods/statistics & numerical data MH - Surveys and Questionnaires MH - Malnutrition/diagnosis MH - Body Mass Index OTO - NOTNLM OT - life cycle OT - nutrition OT - nutrition assessment OT - nutrition screening OT - nutrition support practice OT - pediatrics EDAT- 2024/07/26 12:40 MHDA- 2024/11/13 13:57 CRDT- 2024/07/25 02:33 PHST- 2024/06/26 00:00 [revised] PHST- 2023/12/14 00:00 [received] PHST- 2024/06/28 00:00 [accepted] PHST- 2024/11/13 13:57 [medline] PHST- 2024/07/26 12:40 [pubmed] PHST- 2024/07/25 02:33 [entrez] AID - 10.1002/ncp.11193 [doi] PST - ppublish SO - Nutr Clin Pract. 2024 Dec;39(6):1483-1492. doi: 10.1002/ncp.11193. Epub 2024 Jul 24. PMID- 39046323 OWN - NLM STAT- MEDLINE DCOM- 20240814 LR - 20240814 IS - 1466-447X (Electronic) IS - 0264-0414 (Linking) VI - 42 IP - 12 DP - 2024 Jun TI - Development of the Physical Literacy in Adults Scale (PLAS). PG - 1099-1111 LID - 10.1080/02640414.2024.2383486 [doi] AB - Physical literacy relates to an individual's capacity to live a physically active and healthy lifestyle across the lifespan. Our understanding of physical literacy as a lifelong journey is hindered by a lack of valid measurement for adult populations. In response, we created a measure of physical literacy applicable to adults. A sample of 1180 adults answered a series of existing questionnaires assessing aspects of physical literacy. Using exploratory and confirmatory factor analysis techniques, we reduced the items to a 23-item six factor model, which had good fit to the data in both the exploratory analysis (chi(2) (130) = 254.770, p < 0.001; TLI = 0.965; RMSEA = 0.040 (95% CI: 0.031, 0.049)) and confirmatory analysis (chi(2) ;(130) = 252.005, p < 0.001; TLI = 0.957; RMSEA = 0.046 (95% CI: 0.036, 0.056)). The resulting subjective measure, the Physical Literacy in Adults Scale (PLAS), is a single psychometric measure applicable to adults aged 18-75 years. The PLAS covers four domains (physical, psychological, social and cognitive) of physical literacy to provide a holistic physical literacy outcome. The PLAS represents an appropriate way to assess adult physical literacy, providing an important first step in understanding physical literacy as a lifelong journey. FAU - Naylor, Annaleise AU - Naylor A AUID- ORCID: 0000-0002-1689-725X AD - Research Institute for Sport and Exercise, University of Canberra, Canberra, Australia. FAU - Flood, Andrew AU - Flood A AD - Research Institute for Sport and Exercise, University of Canberra, Canberra, Australia. FAU - Barnett, Lisa M AU - Barnett LM AD - Institute for Physical Activity and Nutrition, Deakin University, Victoria, Australia. FAU - Keegan, Richard AU - Keegan R AD - Research Institute for Sport and Exercise, University of Canberra, Canberra, Australia. LA - eng PT - Journal Article DEP - 20240724 PL - England TA - J Sports Sci JT - Journal of sports sciences JID - 8405364 SB - IM MH - Humans MH - Adult MH - Middle Aged MH - Aged MH - *Psychometrics MH - Female MH - Male MH - Adolescent MH - Young Adult MH - *Health Literacy MH - Factor Analysis, Statistical MH - Surveys and Questionnaires MH - *Exercise/psychology MH - Healthy Lifestyle MH - Reproducibility of Results OTO - NOTNLM OT - Physical literacy OT - adults OT - factor analysis OT - measure creation OT - psychometrics EDAT- 2024/07/24 12:42 MHDA- 2024/08/14 06:42 CRDT- 2024/07/24 09:53 PHST- 2024/08/14 06:42 [medline] PHST- 2024/07/24 12:42 [pubmed] PHST- 2024/07/24 09:53 [entrez] AID - 10.1080/02640414.2024.2383486 [doi] PST - ppublish SO - J Sports Sci. 2024 Jun;42(12):1099-1111. doi: 10.1080/02640414.2024.2383486. Epub 2024 Jul 24. PMID- 39045963 OWN - NLM STAT- MEDLINE DCOM- 20240724 LR - 20240801 IS - 1806-9282 (Electronic) IS - 0104-4230 (Print) IS - 0104-4230 (Linking) VI - 70 IP - 6 DP - 2024 TI - Accuracy of neck circumference in the diagnosis of overweight in children. PG - e20240049 LID - S0104-42302024000600618 [pii] LID - 10.1590/1806-9282.20240049 [doi] LID - e20240049 AB - OBJECTIVE: The objective of this study was to estimate the accuracy of measuring neck circumference as a diagnostic method for overweight in 10-year-old children. METHODS: A cross-sectional diagnostic accuracy study was performed in 2019. The population was composed of 942 school children from the municipality of Palhoca, SC, Brazil. For each measurement of the neck circumference, sensitivity, specificity, positive and negative predictive values, likelihood ratio for a positive test, and accuracy were estimated using the receiver operator characteristic curve, with body mass index as a reference. RESULTS: The estimated overall accuracy was 88.9%. For males, the accuracy was 90.1%, and for females, 88.5%. A 30.0 cm neck circumference had a sensitivity of 22.8%, a specificity of 95.4%, a positive predictive value of 76.6%, a negative predictive value of 65.3%, a likelihood ratio for a positive test of 5.0, and an accuracy of 66.7% for all students. CONCLUSION: Neck circumference showed a global accuracy of 88.9% as a method for diagnosing overweight in 10-year-old children. Predictive values showed high values, mainly starting with a neck circumference of 30 cm. FAU - Traebert, Guilherme de Azevedo AU - Traebert GA AUID- ORCID: 0000-0003-4794-1628 AD - Universidade do Sul de Santa Catarina, School of Medicine - Palhoca (SC), Brazil. FAU - Albino, Andre Legat AU - Albino AL AUID- ORCID: 0009-0008-0029-6530 AD - Universidade do Sul de Santa Catarina, School of Medicine - Palhoca (SC), Brazil. FAU - Zaidan, Milcia Almeida AU - Zaidan MA AUID- ORCID: 0000-0003-2112-999X AD - Universidade do Sul de Santa Catarina, School of Medicine - Palhoca (SC), Brazil. FAU - Bobinski, Franciane AU - Bobinski F AUID- ORCID: 0000-0002-3537-1712 AD - Universidade do Sul de Santa Catarina, Post-Graduation Program in Health Sciences - Palhoca (SC), Brazil. FAU - Ribeiro, Francieli Pereira AU - Ribeiro FP AUID- ORCID: 0009-0005-0945-3342 AD - Universidade do Sul de Santa Catarina, Post-Graduation Program in Health Sciences - Palhoca (SC), Brazil. FAU - Traebert, Eliane AU - Traebert E AUID- ORCID: 0000-0001-9667-7216 AD - Universidade do Sul de Santa Catarina, School of Medicine - Palhoca (SC), Brazil. AD - Universidade do Sul de Santa Catarina, Post-Graduation Program in Health Sciences - Palhoca (SC), Brazil. FAU - Traebert, Jefferson AU - Traebert J AUID- ORCID: 0000-0002-7389-985X AD - Universidade do Sul de Santa Catarina, School of Medicine - Palhoca (SC), Brazil. AD - Universidade do Sul de Santa Catarina, Post-Graduation Program in Health Sciences - Palhoca (SC), Brazil. LA - eng PT - Journal Article DEP - 20240719 PL - Brazil TA - Rev Assoc Med Bras (1992) JT - Revista da Associacao Medica Brasileira (1992) JID - 9308586 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - Cross-Sectional Studies MH - *Neck/anatomy & histology MH - *Body Mass Index MH - *Sensitivity and Specificity MH - Brazil MH - *Predictive Value of Tests MH - Reproducibility of Results MH - Pediatric Obesity/diagnosis MH - ROC Curve MH - Reference Values MH - Overweight/diagnosis MH - Anthropometry/methods PMC - PMC11288280 COIS- Conflicts of interest: the authors declare there is no conflicts of interest. EDAT- 2024/07/24 12:43 MHDA- 2024/07/24 12:44 PMCR- 2024/07/19 CRDT- 2024/07/24 07:23 PHST- 2024/01/16 00:00 [received] PHST- 2024/02/19 00:00 [accepted] PHST- 2024/07/24 12:44 [medline] PHST- 2024/07/24 12:43 [pubmed] PHST- 2024/07/24 07:23 [entrez] PHST- 2024/07/19 00:00 [pmc-release] AID - S0104-42302024000600618 [pii] AID - 10.1590/1806-9282.20240049 [doi] PST - epublish SO - Rev Assoc Med Bras (1992). 2024 Jul 19;70(6):e20240049. doi: 10.1590/1806-9282.20240049. eCollection 2024. PMID- 39045768 OWN - NLM STAT- MEDLINE DCOM- 20250529 LR - 20250529 IS - 2162-5220 (Electronic) IS - 1710-3568 (Linking) VI - 36 IP - 3 DP - 2025 May-Jun TI - Validation of IGA*BSA in Assessing Disease Severity and Response in Patients with Atopic Dermatitis: A Retrospective Cohort Study in China. PG - 258-264 LID - 10.1089/derm.2024.0226 [doi] AB - Background: Accurate evaluation of atopic dermatitis (AD) severity is crucial to determine and adjust treatment options. Previous studies have found the product of Investigator's Global Assessment (IGA) and affected body surface area (BSA) to be a simple tool, which requires further verification. Objective: To determine the validity of IGA*BSA in assessing the severity of AD across all age, sex, BMI and disease severity groups. Method: We performed a retrospective study of AD using data from a national cohort (China Type II Inflammatory Skin Disease Clinical Research and Standardized Diagnosis and Treatment Project). Results: Overall, 3051 participants were included in the final analysis. IGA*BSA correlated better with objective measures than with subjective measures. IGA*BSA significantly correlated with Eczema Area and Severity Index (EASI) (r = 0.81), which was stronger than either IGA or BSA alone with EASI, regardless of age, sex, Body Mass Index (BMI), and disease severity groups. Besides, IGA*BSA mild, moderate, and severe groups were associated with significantly higher scores of other assessments and had moderate to fair concordance with other assessments severity strata. At follow-up, the concordance of improvement between IGA*BSA 50/75/90 and EASI 50/75/90 was observed (k = 0.65, 0.62, 0.58, respectively). Conclusion: IGA*BSA appears to be a valid objective assessment of AD severity and improvement over time across all age, sex, BMI, and disease severity subgroups in the clinical practice. FAU - Yang, Chener AU - Yang C AUID- ORCID: 0009-0005-7592-8617 AD - From the Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, China. AD - Shantou University Medical College, Shantou, China. FAU - Wu, Xia AU - Wu X AD - From the Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, China. AD - National Clinical Research Center for Skin and Immune Disease, Beijing, China. FAU - He, Jing AU - He J AD - From the Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, China. FAU - Liao, Yan AU - Liao Y AD - From the Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, China. FAU - Chen, Jiaying AU - Chen J AUID- ORCID: 0000-0002-2841-8623 AD - From the Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, China. AD - Shantou University Medical College, Shantou, China. FAU - Dou, Xia AU - Dou X AD - From the Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, China. AD - National Clinical Research Center for Skin and Immune Disease, Beijing, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20240724 PL - United States TA - Dermatitis JT - Dermatitis : contact, atopic, occupational, drug JID - 101207335 SB - IM MH - Humans MH - *Dermatitis, Atopic/diagnosis/pathology MH - Retrospective Studies MH - Male MH - Female MH - *Severity of Illness Index MH - Adult MH - China MH - *Body Surface Area MH - Middle Aged MH - Young Adult MH - Adolescent MH - Body Mass Index MH - Child EDAT- 2024/07/24 06:42 MHDA- 2025/05/29 20:16 CRDT- 2024/07/24 05:43 PHST- 2025/05/29 20:16 [medline] PHST- 2024/07/24 06:42 [pubmed] PHST- 2024/07/24 05:43 [entrez] AID - 10.1089/derm.2024.0226 [doi] PST - ppublish SO - Dermatitis. 2025 May-Jun;36(3):258-264. doi: 10.1089/derm.2024.0226. Epub 2024 Jul 24. PMID- 39044205 OWN - NLM STAT- MEDLINE DCOM- 20240724 LR - 20240913 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 24 IP - 1 DP - 2024 Jul 23 TI - Post-discharge complications and hospital readmissions are associated with nutritional risk and malnutrition status in a cohort of Canadian pediatric patients. PG - 469 LID - 10.1186/s12887-024-04941-6 [doi] LID - 469 AB - BACKGROUND: This study constitutes a secondary analysis of a prospective cohort aiming to evaluate the potential correlation between nutritional risk and status at admission with the occurrence of post-discharge complications and hospital readmissions in children receiving care at high resource Centres. METHODS: Data was collected from 5 Canadian tertiary pediatric Centers between 2012 and 2016. Nutritional risk and status were evaluated at hospital admission with validated tools (STRONGkids and Subjective Global Nutrition Assessment [SGNA]) and anthropometric measurements. Thirty days after discharge, occurrence of post-discharge complications and hospital readmission were documented. RESULTS: A total of 360 participants were included in the study (median age, 6.1 years; median length of stay, 5 days). Following discharge, 24.1% experienced complications and 19.5% were readmitted to the hospital. The odds of experiencing complications were nearly tripled for participants with a high nutritional risk compared to a low risk (OR = 2.85; 95% CI [1.08-7.54]; P = 0.035) and those whose caregivers reported having a poor compared to a good appetite (OR = 2.96; 95% CI [1.59-5.50]; P < 0.001). According to SGNA, patients identified as malnourished had significantly higher odds of complications (OR, 1.92; 95% CI, 1.15-3.20; P = 0.013) and hospital readmission (OR, 1.95; 95% CI, 1.12-3.39; P = 0.017) than to those well-nourished. CONCLUSIONS: This study showed that complications and readmission post-discharge are common, and these are more likely to occur in malnourished children compared to their well-nourished counterparts. Enhancing nutritional care during admission, at discharge and in the community may be an area for future outcome optimization. CI - (c) 2024. The Author(s). FAU - Letourneau, Joelle AU - Letourneau J AD - Department of Nutrition, Universite de Montreal, Research Center CHU Sainte-Justine, 3175 Ch de la Cote-Sainte-Catherine, Room 4.17.006, Montreal, QC, H3T 1C5, Canada. FAU - Belanger, Veronique AU - Belanger V AD - Department of Nutrition, Universite de Montreal, Research Center CHU Sainte-Justine, 3175 Ch de la Cote-Sainte-Catherine, Room 4.17.006, Montreal, QC, H3T 1C5, Canada. FAU - Marchand, Valerie AU - Marchand V AD - Department of Pediatrics, Universite de Montreal, CHU Sainte-Justine, Montreal, QC, Canada. FAU - Boctor, Dana L AU - Boctor DL AD - Alberta Children's Hospital, University of Calgary, Calgary, AB, Canada. FAU - Rashid, Mohsin AU - Rashid M AD - IWK Health Center, Dalhousie University, Halifax, NS, Canada. FAU - Avinashi, Vishal AU - Avinashi V AD - Division of Gastroenterology, Hepatology and Nutrition, British Columbia Children's Hospital, Vancouver, BC, Canada. FAU - Groleau, Veronique AU - Groleau V AD - Department of Pediatrics, Universite de Montreal, CHU Sainte-Justine, Montreal, QC, Canada. FAU - Spahis, Schohraya AU - Spahis S AD - Department of Nutrition, Universite de Montreal, Research Center CHU Sainte-Justine, 3175 Ch de la Cote-Sainte-Catherine, Room 4.17.006, Montreal, QC, H3T 1C5, Canada. FAU - Levy, Emile AU - Levy E AD - Department of Nutrition, Universite de Montreal, Research Center CHU Sainte-Justine, 3175 Ch de la Cote-Sainte-Catherine, Room 4.17.006, Montreal, QC, H3T 1C5, Canada. FAU - Marcil, Valerie AU - Marcil V AD - Department of Nutrition, Universite de Montreal, Research Center CHU Sainte-Justine, 3175 Ch de la Cote-Sainte-Catherine, Room 4.17.006, Montreal, QC, H3T 1C5, Canada. valerie.marcil@umontreal.ca. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20240723 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Patient Readmission/statistics & numerical data MH - Male MH - Female MH - Child MH - Canada/epidemiology MH - *Patient Discharge MH - Prospective Studies MH - Child, Preschool MH - *Nutritional Status MH - *Nutrition Assessment MH - Adolescent MH - Infant MH - Risk Factors MH - Malnutrition/epidemiology/etiology MH - Child Nutrition Disorders/epidemiology PMC - PMC11265476 OTO - NOTNLM OT - Child, Hospitalized OT - Malnutrition OT - Nutritional Status OT - Patient Readmission OT - Risk Assessment COIS- J.L. was an employee of Abbott Laboratories at the time of analyzing the data and writing the manuscript. No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article. The authors declares that they have no other competing interests. EDAT- 2024/07/24 00:42 MHDA- 2024/07/24 06:41 PMCR- 2024/07/23 CRDT- 2024/07/23 23:44 PHST- 2023/12/01 00:00 [received] PHST- 2024/07/11 00:00 [accepted] PHST- 2024/07/24 06:41 [medline] PHST- 2024/07/24 00:42 [pubmed] PHST- 2024/07/23 23:44 [entrez] PHST- 2024/07/23 00:00 [pmc-release] AID - 10.1186/s12887-024-04941-6 [pii] AID - 4941 [pii] AID - 10.1186/s12887-024-04941-6 [doi] PST - epublish SO - BMC Pediatr. 2024 Jul 23;24(1):469. doi: 10.1186/s12887-024-04941-6. PMID- 39043794 OWN - NLM STAT- MEDLINE DCOM- 20240723 LR - 20240805 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Jul 23 TI - Development and validation of the Perceived Effectiveness of Nutrition Messages Scale. PG - 16870 LID - 10.1038/s41598-024-67751-x [doi] LID - 16870 AB - An understanding of the extent to which target audiences consider different nutrition-related messages to be effective could assist campaign developers design more persuasive communications. Accordingly, this study sought to develop and assess the utility of the Perceived Effectiveness of Nutrition Messages Scale (PENMS). A longitudinal online survey was completed by Australian adults (n = 5,014 at Time 1 and 2,880 at Time 2). At T1, respondents saw one of two messages promoting healthy eating. They were then administered the PENMS, and asked how likely they were to engage in the behaviour specified in the message. Respondents completed the PENMS again at T2. An exploratory factor analysis was performed on PENMS scores and measures of reliability and validity obtained. Two factors were identified: 'effects perceptions' (Factor 1) and 'message perceptions' (Factor 2). Internal consistency of scores was 0.82 for Factor 1 and 0.70 for Factor 2. Test re-test reliability was 0.76 and 0.69 for Factors 1 and 2, respectively. Scores on both factors were moderately correlated with behavioural intentions. The favourable results for PENMS scores suggest the scale may be a useful tool for assessing the extent to which target audiences consider different nutrition-related messages to be effective. CI - (c) 2024. The Author(s). FAU - Jongenelis, Michelle I AU - Jongenelis MI AD - Melbourne Centre for Behaviour Change, Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, VIC, 3056, Australia. michelle.jongenelis@unimelb.edu.au. FAU - Booth, Leon AU - Booth L AD - The George Institute for Global Health, University of New South Wales, Sydney, Australia. FAU - Pettigrew, Simone AU - Pettigrew S AD - The George Institute for Global Health, University of New South Wales, Sydney, Australia. LA - eng GR - APP1142620/National Health and Medical Research Council/ PT - Journal Article PT - Validation Study DEP - 20240723 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Middle Aged MH - Australia MH - Surveys and Questionnaires MH - *Health Promotion/methods MH - Reproducibility of Results MH - Diet, Healthy MH - Young Adult MH - Adolescent MH - Longitudinal Studies MH - Aged PMC - PMC11266493 OTO - NOTNLM OT - Diet OT - Factor analysis OT - Nutrition OT - Perceived message effectiveness OT - Reliability OT - Validity COIS- The authors declare no competing interests. EDAT- 2024/07/24 00:42 MHDA- 2024/07/24 00:43 PMCR- 2024/07/23 CRDT- 2024/07/23 23:25 PHST- 2023/10/15 00:00 [received] PHST- 2024/07/15 00:00 [accepted] PHST- 2024/07/24 00:43 [medline] PHST- 2024/07/24 00:42 [pubmed] PHST- 2024/07/23 23:25 [entrez] PHST- 2024/07/23 00:00 [pmc-release] AID - 10.1038/s41598-024-67751-x [pii] AID - 67751 [pii] AID - 10.1038/s41598-024-67751-x [doi] PST - epublish SO - Sci Rep. 2024 Jul 23;14(1):16870. doi: 10.1038/s41598-024-67751-x. PMID- 39043375 OWN - NLM STAT- MEDLINE DCOM- 20240904 LR - 20241118 IS - 1460-2350 (Electronic) IS - 0268-1161 (Print) IS - 0268-1161 (Linking) VI - 39 IP - 9 DP - 2024 Sep 1 TI - Survey on ART and IUI: legislation, regulation, funding, and registries in European countries-an update. PG - 1909-1924 LID - 10.1093/humrep/deae163 [doi] AB - STUDY QUESTION: How are ART and IUI regulated, funded, and registered in European countries, and how has the situation changed since 2018? SUMMARY ANSWER: Of the 43 countries performing ART and IUI in Europe, and participating in the survey, specific legislation exists in only 39 countries, public funding varies across and sometimes within countries (and is lacking or minimal in four countries), and national registries are in place in 33 countries; only a small number of changes were identified, most of them in the direction of improving accessibility, through increased public financial support and/or opening access to additional subgroups. WHAT IS KNOWN ALREADY: The annual reports of the European IVF-Monitoring Consortium (EIM) clearly show the existence of different approaches across Europe regarding accessibility to and efficacy of ART and IUI treatments. In a previous survey, some coherent information was gathered about how those techniques were regulated, funded, and registered in European countries, showing that diversity is the paradigm in this medical field. STUDY DESIGN, SIZE, DURATION: A survey was designed using the SurveyMonkey tool consisting of 90 questions covering several domains (legal, funding, and registry) and considering specific details on the situation of third-party donations. New questions widened the scope of the previous survey. Answers refer to the situation of countries on 31 December 2022. PARTICIPANTS/MATERIALS, SETTINGS, METHODS: All members of the EIM were invited to participate. The received answers were checked and initial responders were asked to address unclear answers and to provide any additional information considered relevant. Tables resulting from the consolidated data were then sent to members of the Committee of National Representatives of ESHRE, requesting a second check. Conflicting information was clarified by direct contact. MAIN RESULTS AND THE ROLE OF CHANCE: Information was received from 43 out of the 45 European countries where ART and IUI are performed. There were 39 countries with specific legislation on ART, and artificial insemination was considered an ART technique in 33 of them. Accessibility is limited to infertile couples only in 8 of the 43 countries. In 5 countries, ART and IUI are permitted also for treatments of single women and all same sex couples, while a total of 33 offer treatment to single women and 19 offer treatment to female couples. Use of donated sperm is allowed in all except 2 countries, oocyte donation is allowed in 38, simultaneous donation of sperm and oocyte is allowed in 32, and embryo donation is allowed in 29 countries. Preimplantation genetic testing (PGT)-M/SR (for monogenetic disorders, structural rearrangements) is not allowed in 3 countries and PGT-A (for aneuploidy) is not allowed in 10; surrogacy is accepted in 15 countries. Except for marital/sexual situation, female age is the most frequently reported limiting criterion for legal access to ART: minimal age is usually set at 18 years and the maximum ranges from 42 to 54 with some countries not using numeric definition. Male maximum age is set in very few countries. Where third-party donors are permitted, age is frequently a limiting criterion (male maximum age ranging from 35 to 50; female maximum age from 30 to 37). Other legal restrictions in third-party donation are the number of children born from the same donor (or, in some countries, the number of families with children from the same donor) and, in 12 countries, there is a maximum number of oocyte donations. How countries deal with the anonymity is diverse: strict anonymity, anonymity just for the recipients (not for children when reaching legal adulthood age), a mixed system (anonymous and non-anonymous donations), and strict non-anonymity. Inquiring about donors' genetic screening showed that most countries have enforced either mandatory or scientific recommendations that exclude the most prevalent genetic diseases, although, again, diversity is evident. Reimbursement/compensation systems exist in more than 30 European countries, with around 10 describing clearly defined maximum amounts considered acceptable. Public funding systems are extremely variable. One country provides no financial assistance to ART/IUI patients and three offer only minimal support. Limits to the provision of funding are defined in the others i.e. age (female maximum age is the most used), existence of previous children, BMI, maximum number of treatments publicly supported, and techniques not entitled for funding. In a few countries reimbursement is linked to a clinical policy. The definitions of the type of expenses covered within an IVF/ICSI cycle, up to which limit, and the proportion of out-of-pocket costs for patients are also extremely dissimilar. National registries of ART are in place in 33 out of the 43 countries contributing to the survey and a registry of donors exists in 19 of them. When comparing with the results of the previous survey, the main changes are: (i) an extension of the beneficiaries of ART techniques (and IUI), evident in nine countries; (ii) public financial support exists now in Albania and Armenia; (iii) in Luxembourg, the only ART centre expanded its on-site activities; (iv) donor-conceived children are entitled to know the donor identity in six countries more than in 2018; and (v) four more countries have set a maximum number of oocyte donations. LIMITATIONS, REASONS FOR CAUTION: Although the responses were provided by well-informed and committed individuals and submitted to double checking, no formal validation by official bodies was in place. Therefore, possible inaccuracies cannot be excluded. The results presented are a cross-section in time, and ART and IUI frameworks within European countries undergo continuous modification. Finally, some domains of ART activity were deliberately left out of the scope of this survey. WIDER IMPLICATIONS OF THE FINDINGS: Our results offer a detailed updated view of the ART and IUI situation in European countries. It provides extensive answers to many relevant questions related to ART usage at the national level and could be used by institutions and policymakers at both national and European levels. STUDY FUNDING/COMPETING INTEREST(S): The study has no external funding, and all costs were covered by ESHRE. There were no competing interests. CI - (c) The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. CN - European IVF-Monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE) FAU - Calhaz-Jorge, C AU - Calhaz-Jorge C AUID- ORCID: 0000-0003-2941-113X AD - Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal. FAU - Smeenk, J AU - Smeenk J AD - Department of Obstetrics and Gynaecology, Elisabeth Twee Steden Hospital Tilburg, Tilburg, The Netherlands. FAU - Wyns, C AU - Wyns C AD - Laboratoire d'andrologie, Pole de recherche en Physiologie de la Reproduction, Institut de Recherche Experimentale et Clinique (IREC), Universite Catholique de Louvain, Brussels, Belgium. FAU - De Neubourg, D AU - De Neubourg D AUID- ORCID: 0000-0002-9159-5083 AD - Center for Reproductive Medicine, Antwerp University Hospital, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. FAU - Baldani, D P AU - Baldani DP AD - Department of Obstetrics and Gynecology, Division for Gynecological Endocrinology and Reproductive Medicine, School of Medicine and Clinical Hospital Centre Zagreb, University of Zagreb, Zagreb, Croatia. FAU - Bergh, C AU - Bergh C AD - Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Goteborg, Sweden. AD - Institute of Clinical Sciences, Goteborg University, Goteborg, Sweden. FAU - Cuevas-Saiz, I AU - Cuevas-Saiz I AD - Hospital General Universitario de Valencia, Valencia, Spain. FAU - De Geyter, Ch AU - De Geyter C AUID- ORCID: 0000-0002-0889-6310 AD - Institute of Reproductive Medicine and Gynecological Endocrinology (RME), Basel, Switzerland. FAU - Kupka, M S AU - Kupka MS AD - Gynaekologicum Hamburg, Center for Reproductive Medicine, Hamburg, Germany. FAU - Rezabek, K AU - Rezabek K AUID- ORCID: 0000-0002-1538-9894 AD - Department of Gynaecology, Obstetrics and Neonatology First Faculty of Medicine, Charles University and General University Hospital, Praha, Czech Republic. FAU - Tandler-Schneider, A AU - Tandler-Schneider A AD - Fertility Center Berlin, Berlin, Germany. FAU - Goossens, V AU - Goossens V AUID- ORCID: 0000-0002-9342-2143 AD - ESHRECentral Office, Grimbergen, Belgium. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Hum Reprod JT - Human reproduction (Oxford, England) JID - 8701199 SB - IM MH - Europe MH - Humans MH - *Registries MH - *Reproductive Techniques, Assisted/legislation & jurisprudence/economics/statistics & numerical data MH - Female MH - Surveys and Questionnaires MH - Insemination, Artificial/economics/legislation & jurisprudence MH - Fertilization in Vitro/economics/legislation & jurisprudence PMC - PMC11373472 OTO - NOTNLM OT - ART OT - ICSI OT - IUI OT - IVF OT - embryo donation OT - fertility preservation OT - gamete donation OT - legislation OT - public funding OT - registry COIS- There are no competing interests. EDAT- 2024/07/24 00:42 MHDA- 2024/09/04 12:42 PMCR- 2024/07/23 CRDT- 2024/07/23 19:52 PHST- 2024/05/16 00:00 [received] PHST- 2024/06/10 00:00 [revised] PHST- 2024/09/04 12:42 [medline] PHST- 2024/07/24 00:42 [pubmed] PHST- 2024/07/23 19:52 [entrez] PHST- 2024/07/23 00:00 [pmc-release] AID - 7718783 [pii] AID - deae163 [pii] AID - 10.1093/humrep/deae163 [doi] PST - ppublish SO - Hum Reprod. 2024 Sep 1;39(9):1909-1924. doi: 10.1093/humrep/deae163. PMID- 39043223 OWN - NLM STAT- MEDLINE DCOM- 20260420 LR - 20260420 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) VI - 32 IP - 2 DP - 2026 Mar TI - Validity of a digital photo-based dietary assessment tool: Development and initial evaluation. PG - 703-711 LID - 10.1177/02601060241239095 [doi] AB - Background and aim: To evaluate the validity and user satisfaction of a digital photo-based dietary assessment tool as an alternative to the hand-written paper record method that assists researchers during the pandemic. This study compared nutrient intake and users' satisfaction with methods between a digital photo-based dietary assessment tool, known as the Nutrinote Gama app, and food weighing as the gold standard. Methods: Fifty college students majoring in food and nutrition (90% were women; median age, 21 years) took pictures of their foods and beverages before and after consumption and then uploaded them to the Nutrinote Gama application. Trained nutritionists evaluated plate wastes, and nutritional content was revealed on the Nutrinote Gama application. Parallel to the photo-based method, they kept a weight dietary record and sent it to the researcher. A questionnaire was used to assess participants' satisfaction. Results: No statistical differences (p = 0.89) were observed in the measurement of energy intake between Nutrinote Gama (mean +/- standard deviation [SD] = 582.8 +/- 131) and food weighing (mean +/- SD = 566.1 +/- 133). No statistical differences (p = 0.59) were also observed in the measurement of protein, fat (p = 0.434), and carbohydrate (p = 230). The energy, protein, fat, and carbohydrate intakes estimated from the two methods were significantly correlated (r = 0.86, 0.870, 0.811, 0.738, respectively). Over 70% of participants were satisfied with the photo-based record. Conclusion: The results indicate that this digital photo-based dietary assessment tool is valid and user-friendly to estimate nutrient intake. FAU - Budiningsari, Dwi AU - Budiningsari D AUID- ORCID: 0000-0002-1242-4682 AD - Department of Health Nutrition, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University, Yogyakarta, Indonesia. FAU - Syahrian, Firma AU - Syahrian F AD - Department of Electrical and Informatics Engineering, Vocational School, Universitas Gadjah Mada, Yogyakarta, Indonesia. RINGGOLD: 59166 LA - eng PT - Journal Article PT - Validation Study DEP - 20240723 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 SB - IM MH - Humans MH - Female MH - Male MH - Young Adult MH - *Nutrition Assessment MH - *Photography/methods MH - Energy Intake MH - Diet Records MH - Reproducibility of Results MH - *Mobile Applications MH - Adult MH - *Diet MH - Surveys and Questionnaires MH - Students MH - Adolescent OTO - NOTNLM OT - Macronutrient intake OT - photo-based dietary assessment tool OT - satisfaction OT - validity COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2024/07/24 00:42 MHDA- 2026/04/21 17:49 CRDT- 2024/07/23 19:03 PHST- 2026/04/21 17:49 [medline] PHST- 2024/07/24 00:42 [pubmed] PHST- 2024/07/23 19:03 [entrez] AID - 10.1177/02601060241239095 [doi] PST - ppublish SO - Nutr Health. 2026 Mar;32(2):703-711. doi: 10.1177/02601060241239095. Epub 2024 Jul 23. PMID- 39040929 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240724 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 11 DP - 2024 TI - The usefulness of total body protein mass models for adolescent athletes. PG - 1439208 LID - 10.3389/fnut.2024.1439208 [doi] LID - 1439208 AB - The present study aimed to assess the utility of a less laborious technique for estimating total body protein (TBPro) in young athletes, using a multicomponent model as the criterion method. A total of 88 (49 boys and 39 girls) adolescent athletes (age: 15.2 +/- 1.5 years; body mass index: 21.2 +/- 2.7 kg/m(2)) participated. A 6-compartment model was used as the reference method (TBPro(Reference)) involving air displacement plethysmography for body volume, dual-energy X-ray absorptiometry (DXA) for bone mineral content, and deuterium dilution for total body water (TBW). Alternatively, DXA TBPro models were used as TBPro = lean-soft mass (LSM) - HF(FFM) x fat-free mass (FFM) - Ms. - G, where LSM and FFM were assessed using DXA, HF(FFM) is the hydration fraction of the FFM using measured TBW or assumed TBW (adult fraction of 0.732; Lohman's constants or mean observed HF(FFM)), Ms. is soft tissue minerals (Ms = 0.0129 x HF(FFM) x FFM), and G is glycogen calculated as 0.044 x (LSM - HF(FFM) x FFM - Ms). The maturation level was determined by self-assessment. TBPro obtained from DXA using the assumed HF(FFM) explained 73% to 77% of the variance compared to TBPro(Reference.) Meanwhile, using the mean values of measured HF(FFM), the DXA model explained 53 and 36% for boys and girls, respectively. Larger bias (8.6% for boys and 25.8% for girls) and limits of agreement were found for the DXA model using measured HF(FFM) (boys for 66.9% and girls for 70%) compared to an assumed HF(FFM) (bias ranged from 1.5% to 22.5% and limits of agreement ranged from 31.3% to 35.3%). Less complex and demanding TBPro DXA models with the assumed HF(FFM) are valid alternatives for assessing this relevant FFM component in groups of adolescent athletes but are less accurate for individual results. Though future studies should be conducted to test the usefulness of these models in longitudinal and experimental designs, their potential to provide an estimation of protein mass after exercise and diet interventions in young athletes is anticipated. CI - Copyright (c) 2024 Silva, Campa and Sardinha. FAU - Silva, Analiza M AU - Silva AM AD - Exercise and Health Laboratory, CIPER, Faculdade Motricidade Humana, Universidade de Lisboa, Lisbon, Portugal. FAU - Campa, Francesco AU - Campa F AD - Department of Biomedical Sciences, University of Padua, Padua, Italy. FAU - Sardinha, Luis B AU - Sardinha LB AD - Exercise and Health Laboratory, CIPER, Faculdade Motricidade Humana, Universidade de Lisboa, Lisbon, Portugal. LA - eng PT - Journal Article DEP - 20240708 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC11262245 OTO - NOTNLM OT - DXA OT - adolescent athletes OT - body composition OT - multicomponent models OT - total body protein COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2024/07/23 06:42 MHDA- 2024/07/23 06:43 PMCR- 2024/01/01 CRDT- 2024/07/23 04:25 PHST- 2024/05/27 00:00 [received] PHST- 2024/06/24 00:00 [accepted] PHST- 2024/07/23 06:43 [medline] PHST- 2024/07/23 06:42 [pubmed] PHST- 2024/07/23 04:25 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - 10.3389/fnut.2024.1439208 [doi] PST - epublish SO - Front Nutr. 2024 Jul 8;11:1439208. doi: 10.3389/fnut.2024.1439208. eCollection 2024. PMID- 39040017 OWN - NLM STAT- MEDLINE DCOM- 20240812 LR - 20240812 IS - 2042-650X (Electronic) IS - 2042-6496 (Linking) VI - 15 IP - 16 DP - 2024 Aug 12 TI - Association between pre- and post-diagnosis healthy eating index 2020 and ovarian cancer survival: evidence from a prospective cohort study. PG - 8408-8417 LID - 10.1039/d4fo02417f [doi] AB - Background: Previous studies on the association between diet quality and ovarian cancer (OC) survival are limited and inconsistent. We evaluated the relationship between pre- and post-diagnosis diet quality based on the Healthy Eating Index-2020 (HEI-2020), as well as their changes and OC survival. Methods: This prospective cohort study involved 1082 patients with OC aged 18-79 years, enrolled between 2015 and 2022. Detailed dietary intake before and after diagnosis was recorded using a validated food frequency questionnaire. Deaths were ascertained until February 16th, 2023 via medical records and active follow-up. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CI). Results: We included 549 OC cases with a median follow-up of 44.9 months, representing 206 total deaths. Higher HEI scores were associated with better OS (pre-diagnosis: HR(T3 vs. T1) 0.66, 95%CI: 0.46-0.93, HR(1-SD) 0.84, 95%CI: 0.73-0.96; post-diagnosis: HR(T3 vs. T1) 0.68, 95%CI: 0.49-0.96, HR(1-SD) 0.80, 95%CI: 0.69-0.92). Compared to the stable group, the group with decreased HEI scores (>3%) from pre- to post-diagnosis had worse OS (HR 1.93, 95%CI: 1.26-2.97). Conclusion: High pre- and post-diagnosis diet quality was associated with improved OC survival, whereas deterioration in diet quality after diagnosis was associated with decreased OC survival. FAU - Liu, Jia-Cheng AU - Liu JC AD - Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China. fkzlMDT@163.com. FAU - Liu, Fang-Hua AU - Liu FH AD - Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China. wuqj@sj-hospital.org. AD - Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Zhang, De-Yu AU - Zhang DY AD - Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China. fkzlMDT@163.com. FAU - Wang, Xiao-Ying AU - Wang XY AD - Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China. fkzlMDT@163.com. FAU - Wu, Lang AU - Wu L AD - Cancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI, USA. FAU - Li, Yi-Zi AU - Li YZ AD - Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China. wuqj@sj-hospital.org. AD - Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Xu, He-Li AU - Xu HL AD - Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China. wuqj@sj-hospital.org. AD - Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Wei, Yi-Fan AU - Wei YF AD - Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China. wuqj@sj-hospital.org. AD - Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Huang, Dong-Hui AU - Huang DH AD - Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China. wuqj@sj-hospital.org. AD - Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Li, Xiao-Ying AU - Li XY AD - Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China. wuqj@sj-hospital.org. AD - Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Xiao, Qian AU - Xiao Q AD - Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China. fkzlMDT@163.com. AD - Hospital Management Office, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Xie, Meng-Meng AU - Xie MM AD - Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China. fkzlMDT@163.com. FAU - Liu, Pei-Chen AU - Liu PC AD - Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China. fkzlMDT@163.com. FAU - Gao, Song AU - Gao S AD - Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China. fkzlMDT@163.com. FAU - Liu, Chuan AU - Liu C AD - Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China. fkzlMDT@163.com. FAU - Liu, Ning AU - Liu N AD - Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China. fkzlMDT@163.com. FAU - Gong, Ting-Ting AU - Gong TT AD - Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China. fkzlMDT@163.com. FAU - Wu, Qi-Jun AU - Wu QJ AUID- ORCID: 0000-0001-9421-5114 AD - Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China. fkzlMDT@163.com. AD - Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China. wuqj@sj-hospital.org. AD - Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China. AD - NHC Key Laboratory of Advanced Reproductive Medicine and Fertility (China Medical University), National Health Commission, Shenyang, China. LA - eng PT - Journal Article DEP - 20240812 PL - England TA - Food Funct JT - Food & function JID - 101549033 SB - IM MH - Humans MH - Female MH - Middle Aged MH - Prospective Studies MH - Adult MH - *Ovarian Neoplasms/mortality MH - *Diet, Healthy MH - Aged MH - Adolescent MH - Young Adult MH - Proportional Hazards Models EDAT- 2024/07/23 06:42 MHDA- 2024/08/12 18:43 CRDT- 2024/07/23 03:53 PHST- 2024/08/12 18:43 [medline] PHST- 2024/07/23 06:42 [pubmed] PHST- 2024/07/23 03:53 [entrez] AID - 10.1039/d4fo02417f [doi] PST - epublish SO - Food Funct. 2024 Aug 12;15(16):8408-8417. doi: 10.1039/d4fo02417f. PMID- 39039613 OWN - NLM STAT- MEDLINE DCOM- 20250422 LR - 20250815 IS - 1365-2869 (Electronic) IS - 0962-1105 (Print) IS - 0962-1105 (Linking) VI - 34 IP - 2 DP - 2025 Apr TI - The Ecology of Human Sleep (EcoSleep) Cohort Study: Protocol for a longitudinal repeated measurement burst design study to assess the relationship between sleep determinants and outcomes under real-world conditions across time of year. PG - e14225 LID - 10.1111/jsr.14225 [doi] LID - e14225 AB - The interplay of daily life factors, including mood, physical activity, or light exposure, influences sleep architecture and quality. Laboratory-based studies often isolate these determinants to establish causality, thereby sacrificing ecological validity. Furthermore, little is known about time-of-year changes in sleep and circadian-related variables at high resolution, including the magnitude of individual change across time of year under real-world conditions. The Ecology of Human Sleep (EcoSleep) cohort study will investigate the combined impact of sleep determinants on individuals' daily sleep episodes to elucidate which waking events modify sleep patterns. A second goal is to describe high-resolution individual sleep and circadian-related changes across the year to understand intra- and inter-individual variability. This study is a prospective cohort study with a measurement-burst design. Healthy adults aged 18-35 years (N = 12) will be enrolled for 12 months. Participants will continuously wear actimeters and pendant-attached light loggers. A subgroup will also measure interstitial fluid glucose levels (six paticipants). Every 4 weeks, all participants will undergo three consecutive measurement days of four ecological momentary assessments each day ('bursts') to sample sleep determinants during wake. Participants will also continuously wear temperature loggers (iButtons) during the bursts. Body weight will be captured before and after the bursts in the laboratory. The bursts will be separated by two at-home electroencephalogram recordings each night. Circadian phase and amplitude will be estimated during the bursts from hair follicles, and habitual melatonin onset will be derived through saliva sampling. Environmental parameters (bedroom temperature, humidity, and air pressure) will be recorded continuously. CI - (c) 2024 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society. FAU - Biller, Anna M AU - Biller AM AUID- ORCID: 0000-0002-3673-8838 AD - Department Health and Sport Sciences, Chronobiology and Health, Technical University of Munich, TUM School of Medicine and Health, Munich, Germany. AD - Max Planck Institute for Biological Cybernetics, Research Group Translational Sensory and Circadian Neuroscience, Tubingen, Germany. FAU - Fatima, Nayab AU - Fatima N AUID- ORCID: 0009-0006-5856-7642 AD - Department Health and Sport Sciences, Chronobiology and Health, Technical University of Munich, TUM School of Medicine and Health, Munich, Germany. FAU - Hamberger, Chrysanth AU - Hamberger C AUID- ORCID: 0009-0005-1082-3451 AD - Department Health and Sport Sciences, Chronobiology and Health, Technical University of Munich, TUM School of Medicine and Health, Munich, Germany. FAU - Hainke, Laura AU - Hainke L AUID- ORCID: 0000-0002-8348-5554 AD - Department Health and Sport Sciences, Chronobiology and Health, Technical University of Munich, TUM School of Medicine and Health, Munich, Germany. AD - Department of Psychiatry and Psychotherapy, Technical University of Munich, TUM School of Medicine and Health, Munich, Germany. AD - Department of Psychology, Ludwig Maximilian University, Munich, Germany. FAU - Plankl, Verena AU - Plankl V AUID- ORCID: 0009-0006-2030-7052 AD - Department Health and Sport Sciences, Chronobiology and Health, Technical University of Munich, TUM School of Medicine and Health, Munich, Germany. FAU - Nadeem, Amna AU - Nadeem A AUID- ORCID: 0009-0000-4720-6792 AD - Department Health and Sport Sciences, Chronobiology and Health, Technical University of Munich, TUM School of Medicine and Health, Munich, Germany. FAU - Kramer, Achim AU - Kramer A AUID- ORCID: 0000-0001-9671-6078 AD - Laboratory of Chronobiology, Charite-Universitatsmedizin Berlin, Berlin, Germany. FAU - Hecht, Martin AU - Hecht M AUID- ORCID: 0000-0002-5168-4911 AD - Department of Psychology, Helmut Schmidt University, Hamburg, Germany. FAU - Spitschan, Manuel AU - Spitschan M AUID- ORCID: 0000-0002-8572-9268 AD - Department Health and Sport Sciences, Chronobiology and Health, Technical University of Munich, TUM School of Medicine and Health, Munich, Germany. AD - Max Planck Institute for Biological Cybernetics, Research Group Translational Sensory and Circadian Neuroscience, Tubingen, Germany. AD - TUM Institute for Advanced Study (TUM-IAS), Technical University of Munich, Garching, Germany. LA - eng GR - Deutsche Gesellschaft fur Schlafforschung und Schlafmedizin e.V/ GR - TUMSeedFund/Technical University of Munich/ GR - Max Planck Society/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240722 PL - England TA - J Sleep Res JT - Journal of sleep research JID - 9214441 SB - IM MH - Humans MH - Adult MH - *Sleep/physiology MH - Adolescent MH - Prospective Studies MH - Male MH - Female MH - Young Adult MH - *Circadian Rhythm/physiology MH - Longitudinal Studies MH - Ecological Momentary Assessment MH - Research Design MH - Cohort Studies PMC - PMC11911042 OTO - NOTNLM OT - individual sleep differences OT - naturalistic conditions OT - photoperiod OT - prospective cohort study OT - season OT - sleep architecture OT - sleep variability COIS- All authors have completed the ICMJE uniform disclosure form at http://www.icmje.org/disclosure-of-interest/ and declare the following: Anna M. Biller received financial support from the German Sleep Society-Deutsche Gesellschaft fur Schlafforschung und Schlafmedizin e. V. for the submitted work; Laura Hainke has previously been employed at Mentalab GmbH (prior to the submitted work) but is no longer affiliated with the company; Manuel Spitschan received financial support from the TUM Seed Fund and the Max Planck Society (Max Planck Free-Floating Research Group); Verena Plankl is currently employed at the sleep laboratory of the Klinikum Rechts der Isar, Munich, Germany in which the laboratory-based recording are currently planned to take place; Achim Kramer is a shareholder of BodyClock Technologies GmbH and receives partial licencing fees from BodyClock; all other authors declare no financial relationships with any organisation that might have an interest in the submitted work in the previous three years; all authors declare no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2024/07/23 00:42 MHDA- 2025/03/17 00:42 PMCR- 2025/03/17 CRDT- 2024/07/22 23:42 PHST- 2024/04/08 00:00 [revised] PHST- 2024/02/26 00:00 [received] PHST- 2024/04/11 00:00 [accepted] PHST- 2025/03/17 00:42 [medline] PHST- 2024/07/23 00:42 [pubmed] PHST- 2024/07/22 23:42 [entrez] PHST- 2025/03/17 00:00 [pmc-release] AID - JSR14225 [pii] AID - 10.1111/jsr.14225 [doi] PST - ppublish SO - J Sleep Res. 2025 Apr;34(2):e14225. doi: 10.1111/jsr.14225. Epub 2024 Jul 22. PMID- 39039502 OWN - NLM STAT- MEDLINE DCOM- 20240723 LR - 20250129 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 Jul 22 TI - The association between ultra-processed food consumption and health-related quality of life differs across lifestyle and socioeconomic strata. PG - 1955 LID - 10.1186/s12889-024-19351-7 [doi] LID - 1955 AB - BACKGROUND: In this prospective study, we aimed to examine the association between ultra-processed foods and health-related quality of life (HRQoL) and to evaluate the effect of lifestyle and socioeconomic factors on this association. METHODS: This study included 1766 adults (aged 18 to 78, 54.3% women), who took part in the Tehran Lipid and Glucose study. The Short-Form 12-Item Health Survey version 2 was used to determine HRQoL, which includes the physical component summary (PCS) and mental component summary (MCS) scores. Ultra-processed food consumption was assessed using a validated semi-quantitative food frequency questionnaire. Lifestyle (physical activity and smoking status) and socioeconomic factors (education level and employment status) were also determined. General linear models (GLM) were applied to estimate the mean (95% confidence interval) for MCS and PCS scores across the ultra-processed foods tertiles. Additionally, the effect of lifestyle and socioeconomic factors on the relationship between ultra-processed foods and HRQoL was examined using GLM. RESULTS: The median consumption of ultra-processed foods was 11.9% (IQR: 8.2 to 16.8) of total energy intake. There was a significant inverse association between ultra-processed foods consumption and PCS, but not MCS, after adjustment for confounding factors. Significant interactions were observed between ultra-processed food consumption, sex, and occupation on PCS score (all P values < 0.001). The interaction test tended to be significant for smoking status, education levels, and physical activity levels. As ultra-processed food consumption increased, the PCS score significantly decreased in women (P = 0.043), low physical active subjects (P = 0.014), smokers (P = 0.015), and lower-educated individuals (P = 0.022). Non-employed individuals with higher ultra-processed food intake showed a decline in their PCS and MCS scores. While there was no significant difference in MCS score among different strata of lifestyle and socioeconomic status across tertiles of ultra-processed foods. CONCLUSIONS: Higher intake of ultra-processed foods was associated with poorer physical health, particularly among women, those with unhealthy lifestyles, and low socioeconomic conditions. CI - (c) 2024. The Author(s). FAU - Hosseinpour-Niazi, Somayeh AU - Hosseinpour-Niazi S AD - Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box: 19395-4763, No. 24, A'rabi St., Yeman Av., Velenjak, Tehran, Iran. s.hossainpour@yahoo.com. FAU - Niknam, Mahdieh AU - Niknam M AD - Research Center for Social Determinants of Health, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box: 19395-4763, No. 24, A'rabi St., Yeman Av., Velenjak, Tehran, Iran. ma_niknam@yhoo.com. FAU - Amiri, Parisa AU - Amiri P AD - Research Center for Social Determinants of Health, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box: 19395-4763, No. 24, A'rabi St., Yeman Av., Velenjak, Tehran, Iran. FAU - Mirmiran, Parvin AU - Mirmiran P AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Ainy, Elaheh AU - Ainy E AD - Safety Promotion and Injury Prevention Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Izadi, Neda AU - Izadi N AD - Research Center for Social Determinants of Health, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box: 19395-4763, No. 24, A'rabi St., Yeman Av., Velenjak, Tehran, Iran. FAU - Gaeini, Zahra AU - Gaeini Z AD - Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box: 19395-4763, No. 24, A'rabi St., Yeman Av., Velenjak, Tehran, Iran. FAU - Azizi, Fereidoun AU - Azizi F AD - Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. LA - eng GR - 43008752/Shahid Beheshti University of Medical Sciences/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240722 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM EIN - BMC Public Health. 2024 Oct 2;24(1):2688. doi: 10.1186/s12889-024-20189-2. PMID: 39358681 MH - Humans MH - Female MH - Male MH - Adult MH - *Quality of Life MH - Middle Aged MH - *Life Style MH - Iran MH - *Fast Foods/statistics & numerical data MH - Adolescent MH - Prospective Studies MH - Young Adult MH - Aged MH - Socioeconomic Factors MH - Surveys and Questionnaires MH - Food, Processed PMC - PMC11265477 OTO - NOTNLM OT - Health-related quality of life OT - Lifestyle factors OT - Socioeconomic status OT - Ultra-processed foods COIS- The authors declare no competing interests. EDAT- 2024/07/23 00:42 MHDA- 2024/07/23 06:42 PMCR- 2024/07/22 CRDT- 2024/07/22 23:36 PHST- 2024/03/26 00:00 [received] PHST- 2024/07/03 00:00 [accepted] PHST- 2024/07/23 06:42 [medline] PHST- 2024/07/23 00:42 [pubmed] PHST- 2024/07/22 23:36 [entrez] PHST- 2024/07/22 00:00 [pmc-release] AID - 10.1186/s12889-024-19351-7 [pii] AID - 19351 [pii] AID - 10.1186/s12889-024-19351-7 [doi] PST - epublish SO - BMC Public Health. 2024 Jul 22;24(1):1955. doi: 10.1186/s12889-024-19351-7. PMID- 39038911 OWN - NLM STAT- MEDLINE DCOM- 20240722 LR - 20240920 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 8 IP - 1 DP - 2024 Jul 22 TI - Development of machine learning models predicting mortality using routinely collected observational health data from 0-59 months old children admitted to an intensive care unit in Bangladesh: critical role of biochemistry and haematology data. LID - 10.1136/bmjpo-2023-002365 [doi] LID - e002365 AB - INTRODUCTION: Treatment in the intensive care unit (ICU) generates complex data where machine learning (ML) modelling could be beneficial. Using routine hospital data, we evaluated the ability of multiple ML models to predict inpatient mortality in a paediatric population in a low/middle-income country. METHOD: We retrospectively analysed hospital record data from 0-59 months old children admitted to the ICU of Dhaka hospital of International Centre for Diarrhoeal Disease Research, Bangladesh. Five commonly used ML models- logistic regression, least absolute shrinkage and selection operator, elastic net, gradient boosting trees (GBT) and random forest (RF), were evaluated using the area under the receiver operating characteristic curve (AUROC). Top predictors were selected using RF mean decrease Gini scores as the feature importance values. RESULTS: Data from 5669 children was used and was reduced to 3505 patients (10% death, 90% survived) following missing data removal. The mean patient age was 10.8 months (SD=10.5). The top performing models based on the validation performance measured by mean 10-fold cross-validation AUROC on the training data set were RF and GBT. Hyperparameters were selected using cross-validation and then tested in an unseen test set. The models developed used demographic, anthropometric, clinical, biochemistry and haematological data for mortality prediction. We found RF consistently outperformed GBT and predicted the mortality with AUROC of >/=0.87 in the test set when three or more laboratory measurements were included. However, after the inclusion of a fourth laboratory measurement, very minor predictive gains (AUROC 0.87 vs 0.88) resulted. The best predictors were the biochemistry and haematological measurements, with the top predictors being total CO(2), potassium, creatinine and total calcium. CONCLUSIONS: Mortality in children admitted to ICU can be predicted with high accuracy using RF ML models in a real-life data set using multiple laboratory measurements with the most important features primarily coming from patient biochemistry and haematology. CI - (c) Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Das, Subhasish AU - Das S AUID- ORCID: 0000-0002-7852-6569 AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh subhasish.das.bd@gmail.com. AD - Liggins Institute, University of Auckland, Auckland, New Zealand. FAU - Erdman, Lauren AU - Erdman L AD - The Center for Computational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada. AD - Department of Computer Science, University of Toronto, Toronto, Ontario, Canada. AD - Translational Medicine Program, The Hospital for Sick Children, Toronto, Ontario, Canada. AD - James M. Anderson Center for Health Systems Excellence, Cincinnati Children's Hospital Medical Center and University of Cincinnati School of Medicine, Cincinnati, Ohio, USA. FAU - Brals, Daniella AU - Brals D AD - Department of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam, Netherlands. FAU - Boczek, Bartlomiej AU - Boczek B AD - Department of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam, Netherlands. FAU - Hasan, S M Tafsir AU - Hasan SMT AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. FAU - Massara, Paraskevi AU - Massara P AD - The Center for Computational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada. AD - Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada. FAU - Alam, Md Ashraful AU - Alam MA AD - The University of Queensland Poche Centre for Indigenous Health, Saint Lucia, Queensland, Australia. FAU - Fahim, Shah Mohammad AU - Fahim SM AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. AD - Division of Nutritional Sciences, Cornell University, Ithaca, New York, USA. FAU - Mahfuz, Mustafa AU - Mahfuz M AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. FAU - Hoogendoorn, Mark AU - Hoogendoorn M AD - Faculty of Science, Department of Computer Science, Vrije University, Amsterdam, The Netherlands. FAU - Zuiderent-Jerak, Teun AU - Zuiderent-Jerak T AD - Athena Institute, Vrije Universiteit Amsterdam, Amsterdam, Netherlands. FAU - Bandsma, Robert H J AU - Bandsma RHJ AD - Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada. AD - Centre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada. FAU - Ahmed, Tahmeed AU - Ahmed T AUID- ORCID: 0000-0002-4607-7439 AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. FAU - Voskuijl, Wieger AU - Voskuijl W AD - Department of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam, Netherlands. AD - Amsterdam UMC, University of Amsterdam, Amsterdam Centre for Global Child Health & Emma Children's Hospital, Amsterdam, The Netherlands. LA - eng PT - Journal Article DEP - 20240722 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Bangladesh/epidemiology MH - Infant MH - *Machine Learning MH - Retrospective Studies MH - Female MH - Male MH - Child, Preschool MH - Infant, Newborn MH - ROC Curve MH - Hospital Mortality MH - Intensive Care Units/statistics & numerical data PMC - PMC11409392 OTO - NOTNLM OT - Health services research OT - Statistics COIS- Competing interests: No, there are no competing interests. EDAT- 2024/07/23 00:42 MHDA- 2024/07/23 00:43 PMCR- 2024/07/22 CRDT- 2024/07/22 21:02 PHST- 2023/11/11 00:00 [received] PHST- 2024/07/03 00:00 [accepted] PHST- 2024/07/23 00:43 [medline] PHST- 2024/07/23 00:42 [pubmed] PHST- 2024/07/22 21:02 [entrez] PHST- 2024/07/22 00:00 [pmc-release] AID - 10.1136/bmjpo-2023-002365 [pii] AID - bmjpo-2023-002365 [pii] AID - 10.1136/bmjpo-2023-002365 [doi] PST - epublish SO - BMJ Paediatr Open. 2024 Jul 22;8(1):e002365. doi: 10.1136/bmjpo-2023-002365. PMID- 39037676 OWN - NLM STAT- MEDLINE DCOM- 20240730 LR - 20261010 IS - 1708-0428 (Electronic) IS - 0960-8923 (Linking) VI - 34 IP - 8 DP - 2024 Aug TI - Unraveling Postoperative Bleeding Dynamics in Laparoscopic Roux-en-Y Gastric Bypass: Insights from a Single-Center Tranexamic Acid Study. PG - 3012-3020 LID - 10.1007/s11695-024-07411-1 [doi] AB - BACKGROUND: The efficacy of postoperative tranexamic acid (TXA) administration in mitigating bleeding after primary laparoscopic Roux-en-Y gastric bypass (RYGB), a prevalent complication associated with significant morbidities and mortality, and the use of sequential laboratory parameter changes in bleeding screening and TXA impact tracking were investigated. METHODS: This retrospective analysis included RYGB patients (aged 18-65 years, with a body mass index of 35-50 kg/m(2)) over 5 years who were categorized into three groups by evolving treatment regimens: Group A (n = 42) received standard pre- and postoperative enoxaparin (30 mg) every 12 h; Group B (n = 160) received enoxaparin and postoperative TXA (250 mg every 6 h); and Group C (n = 73) received TXA alone. Postoperative bleeding-related adverse events, vital signs, and laboratory changes were compared. RESULTS: Postoperative hemorrhage occurred in 3.6% (10/275) of patients, with no significant intergroup differences. Patients who experienced bleeding had greater decreases in hemoglobin (∆Hb) (2.1 vs. 1.4; p = 0.003), greater ∆Hb > 2 (50% vs. 15%; p = 0.013), and greater use of staples than did those who did not experience bleeding (8 vs. 7; p = 0.001). The ∆Hb values were lower in Groups B (1.4) and C (1.3) than in Group A (1.7, p = 0.011). No significant difference was noted between Groups C and B. CONCLUSION: This study emphasizes the potential of TXA to mitigate postoperative bleeding after RYGB, with no added benefit from excluding enoxaparin. Monitoring patients with a ∆Hb > 2 mg/dl and increased stapler usage is crucial. Further research is needed to validate routine TXA use across different procedures. CI - (c) 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Lo, Hung-Chieh AU - Lo HC AUID- ORCID: 0000-0001-6079-8657 AD - Division of Trauma and Emergency Surgery, Department of Surgery, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. carfishcat@yahoo.com.tw. AD - Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. carfishcat@yahoo.com.tw. AD - TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, Taiwan. carfishcat@yahoo.com.tw. FAU - Hsu, Shih-Chang AU - Hsu SC AD - Department of Emergency, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. AD - Emergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. AD - Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan. FAU - Soong, Ruey-Shyang AU - Soong RS AD - Division of General Surgery, Department of Surgery, Wan Fang Hospital, Taipei Medical University, No.111 Sec.3, Xinglong Rd., Wenshan Dist., Taipei City, 116, Taiwan. AD - College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei City, 110, Taiwan. AD - Division of Transplantation Surgery, Department of Surgery, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. AD - TMU Research Center for Organ Transplantation, Taipei Medical University, College of Medicine, Medical University, Taipei, Taiwan. AD - Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan. FAU - Huang, Shau-Ku AU - Huang SK AD - National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli County, Taiwan. AD - Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, USA. LA - eng GR - 112-wf-swf-06/Taipei Medical University/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240722 PL - United States TA - Obes Surg JT - Obesity surgery JID - 9106714 RN - 6T84R30KC1 (Tranexamic Acid) RN - 0 (Antifibrinolytic Agents) RN - 0 (Enoxaparin) SB - IM MH - Humans MH - *Tranexamic Acid/administration & dosage/therapeutic use MH - *Gastric Bypass/adverse effects/methods MH - Female MH - Retrospective Studies MH - Adult MH - Male MH - *Postoperative Hemorrhage/prevention & control/epidemiology MH - Middle Aged MH - *Antifibrinolytic Agents/administration & dosage/therapeutic use MH - *Obesity, Morbid/surgery MH - *Laparoscopy MH - Enoxaparin/administration & dosage MH - Young Adult MH - Aged MH - Treatment Outcome MH - Adolescent OTO - NOTNLM OT - Bariatric surgery OT - Bleeding OT - Gastric bypass OT - Tranexamic acid EDAT- 2024/07/22 12:43 MHDA- 2024/07/31 00:42 CRDT- 2024/07/22 11:16 PHST- 2024/02/20 00:00 [received] PHST- 2024/07/17 00:00 [accepted] PHST- 2024/07/17 00:00 [revised] PHST- 2024/07/31 00:42 [medline] PHST- 2024/07/22 12:43 [pubmed] PHST- 2024/07/22 11:16 [entrez] AID - 10.1007/s11695-024-07411-1 [pii] AID - 10.1007/s11695-024-07411-1 [doi] PST - ppublish SO - Obes Surg. 2024 Aug;34(8):3012-3020. doi: 10.1007/s11695-024-07411-1. Epub 2024 Jul 22. PMID- 39036369 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240723 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 6 DP - 2024 TI - Comparison of three device generations of the StepWatch Activity Monitor: analysis of model version agreement in pediatric and adult independent ambulators. PG - 1418018 LID - 10.3389/fspor.2024.1418018 [doi] LID - 1418018 AB - PURPOSE: Devices such as the StepWatch Activity Monitor (SAM) have been available for 20 years and have been shown to accurately measure ambulatory activity. This study aimed to evaluate the agreement among the three generations of the StepWatch Activity Monitor (SW3, SW4, and SW5) with respect to stride count. METHODS: A total of 36 participants (age range, 6-55 years) participated in this institutional review board-approved study. The participants concurrently wore three different SAM model devices on the same leg and performed a 6-min walk test (6MWT). A research staff member of the laboratory manually counted the number of strides for the first 2 min of the test (2MWT). Agreement among the device models was evaluated by calculating ANOVAs and interclass correlation coefficients (ICCs) and creating Bland-Altman plots. RESULTS: There was no significant difference among the model versions during the 6MWT and 2MWT (p > 0.05). The ICC for the total stride count was 0.993 (95% CI = 0.988-0.996) during the 2MWT and 0.992 (95% CI = 0.986-0.996) during the 6MWT. There was a near-perfect agreement (ICC >/= 0.990) of each model version to the manually counted strides during the 2MWT. The systematic bias of all three SAM model versions was <1 step. CONCLUSIONS: The results from the present study demonstrate that the stride counts among all three devices are comparable and relative to the manual stride count. All three SAM model versions had an ICC of >0.90. Researchers can safely incorporate historical data from previous SAM model versions with newer data collected with the latest SAM model version. CI - (c) 2024 Stevens, Barrett and Jeans. FAU - Stevens, Wilshaw R Jr AU - Stevens WR Jr AD - Movement Science Lab, Scottish Rite for Children, Dallas, TX, United States. FAU - Barrett, Cody AU - Barrett C AD - Movement Science Lab, Scottish Rite for Children, Dallas, TX, United States. FAU - Jeans, Kelly A AU - Jeans KA AD - Movement Science Lab, Scottish Rite for Children, Dallas, TX, United States. LA - eng PT - Journal Article DEP - 20240705 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC11257887 OTO - NOTNLM OT - accelerometer OT - adults OT - agreement OT - ambulatory activity OT - pediatrics OT - reliability COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/07/22 06:43 MHDA- 2024/07/22 06:44 PMCR- 2024/07/05 CRDT- 2024/07/22 05:31 PHST- 2024/04/15 00:00 [received] PHST- 2024/06/21 00:00 [accepted] PHST- 2024/07/22 06:44 [medline] PHST- 2024/07/22 06:43 [pubmed] PHST- 2024/07/22 05:31 [entrez] PHST- 2024/07/05 00:00 [pmc-release] AID - 10.3389/fspor.2024.1418018 [doi] PST - epublish SO - Front Sports Act Living. 2024 Jul 5;6:1418018. doi: 10.3389/fspor.2024.1418018. eCollection 2024. PMID- 39035680 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260923 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 7 IP - 7 DP - 2024 Jul TI - Estimating the out-of-pocket health expenditure in patients under 5 years with severe malnutrition in Afghanistan in 2023: Findings from a cross-sectional study. PG - e2256 LID - 10.1002/hsr2.2256 [doi] LID - e2256 AB - INTRODUCTION: This study, of significant importance to healthcare professionals, policymakers, researchers, and organizations involved in child healthcare and malnutrition in Afghanistan, aimed to estimate the out-of-pocket expenditure (OOPE) in patients under 5 years old with severe malnutrition in a children's hospital in Herat Province, Afghanistan. METHOD: This study employed a meticulously designed cross-sectional descriptive-analytical approach with practical results. The research population consisted of families with malnourished children under 5 who were referred to Herat Children's Hospital. Data was collected using a comprehensive standard World Health Organization questionnaire to gather demographic information from children in Herat. A carefully selected convenience sampling method was used, with 300 referring patients participating in face-to-face interviews with the supervisors of these children. After obtaining personal consent and coordinating with health officials, interviews were conducted with the caregivers of children under 5 who suffered from severe malnutrition. The data was then analyzed using robust descriptive statistics, quantitative variables, mean and standard deviation, frequency, and relative frequency. Multiple regression analysis was used to determine the factors that most influenced direct payments from patients' pockets, ensuring the reliability and validity of the findings. RESULTS: The results showed that OOPE in both households with seven and less than seven people and more than seven people was 68%. The findings indicated that among the residents of Herat referred to the studied hospital, these people spent 54% of the treatment costs directly out of pocket. In contrast, people in the rural areas of Herat pay 69% of the treatment costs to receive medical services straight out of pocket. The critical point is that 93% of the families have incurred catastrophic expenses to treat their children suffering from severe malnutrition. The research revealed that the patient's location and the education level of the head of the household were the most significant factors affecting out-of-pocket payments by patients. CONCLUSION: Increasing OOPE in rural Afghanistan poses a significant obstacle to equitable healthcare services and access to appropriate medicines. To support the goal of universal healthcare coverage, geographic imbalances, and broad health financing options must be addressed. Strengthening insurance coverage and more government assistance can significantly reduce these patients' out-of-pocket payments. CI - (c) 2024 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Tajik, Amirmohammad AU - Tajik A AUID- ORCID: 0000-0002-3767-9921 AD - School of Pharmacy Mashhad University of Medical Sciences Mashhad Iran. AD - Health Policy Research Center, Institute of Health Shiraz University of Medical Sciences Shiraz Iran. FAU - Ghavami, Vahid AU - Ghavami V AD - Department of Biostatistics, School of Health Mashhad University of Medical Sciences Mashhad Iran. FAU - Popal, Shakib AU - Popal S AD - General Directorate of Human Resources Ministry of Public Health Herat Afghanistan. FAU - Shabanikiya, Hamidreza AU - Shabanikiya H AD - Social Determinants of Health Research Center Mashhad University of Medical Sciences Mashhad Iran. FAU - Varmaghani, Mehdi AU - Varmaghani M AUID- ORCID: 0000-0001-6249-821X AD - Social Determinants of Health Research Center Mashhad University of Medical Sciences Mashhad Iran. AD - Department of Health Economics and Management Sciences, School of Health Mashhad University of Medical Sciences Mashhad Iran. LA - eng PT - Journal Article DEP - 20240718 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC11258197 OTO - NOTNLM OT - Afghanistan OT - child OT - health equity OT - health expenditures OT - healthcare rationing OT - malnutrition COIS- The authors declare no conflict of interest. EDAT- 2024/07/22 06:43 MHDA- 2024/07/22 06:44 PMCR- 2024/07/18 CRDT- 2024/07/22 05:23 PHST- 2024/04/19 00:00 [received] PHST- 2024/07/01 00:00 [revised] PHST- 2024/07/05 00:00 [accepted] PHST- 2024/07/22 06:44 [medline] PHST- 2024/07/22 06:43 [pubmed] PHST- 2024/07/22 05:23 [entrez] PHST- 2024/07/18 00:00 [pmc-release] AID - HSR22256 [pii] AID - 10.1002/hsr2.2256 [doi] PST - epublish SO - Health Sci Rep. 2024 Jul 18;7(7):e2256. doi: 10.1002/hsr2.2256. eCollection 2024 Jul. PMID- 39035189 OWN - NLM STAT- MEDLINE DCOM- 20240722 LR - 20261027 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 12 DP - 2024 TI - Association of heavy metals exposure with lower blood pressure in the population aged 8-17 years: a cross-sectional study based on NHANES. PG - 1411123 LID - 10.3389/fpubh.2024.1411123 [doi] LID - 1411123 AB - BACKGROUND: The existing evidence regarding the joint effect of heavy metals on blood pressure (BP) in children and adolescents is insufficient. Furthermore, the impact of factors such as body weight, fish consumption, and age on their association remains unclear. METHODS: The study utilized original data from the National Health and Nutrition Examination Survey, encompassing 2,224 children and adolescents with complete information on 12 urinary metals (barium, cadmium, cobalt, cesium, molybdenum, lead, antimony, thallium, tungsten, uranium, mercury and arsenic), BP, and core covariates. Various statistical methods, including weighted multiple logistic regression, linear regression, and Weighted Quantile Sum regression (WQS), were employed to evaluate the impact of mixed metal exposure on BP. Sensitivity analysis was conducted to confirm the primary analytical findings. RESULTS: The findings revealed that children and adolescents with low-level exposure to lead (0.40 mug/L, 95%CI: 0.37, 0.42), mercury (0.38 mug/L, 95%CI: 0.35, 0.42) and molybdenum (73.66 mug/L, 95%CI: 70.65, 76.66) exhibited reduced systolic blood pressure (SBP) and diastolic blood pressure (DBP). Conversely, barium (2.39 mug/L, 95%CI: 2.25, 2.54) showed a positive association with increased SBP. A 25th percentile increase in the WQS index is significantly associated with a decrease in SBP of 0.67 mmHg (95%CI, -1.24, -0.10) and a decrease in DBP of 0.59 mmHg (95% CI, -1.06, -0.12), which remains statistically significant even after adjusting for weight. Furthermore, among individuals who consume fish, heavy metals have a more significant influence on SBP. A 25 percentile increase in the WQS index is significantly associated with a decrease of 3.30 mmHg (95% CI, -4.73, -1.87) in SBP, primarily attributed to mercury (27.61%), cadmium (27.49%), cesium (17.98%), thallium (8.49%). The study also identified a declining trend in SBP among children aged 10-17, whereas children aged 11-18 exhibited lower levels of systolic and diastolic blood pressure, along with a reduced risk of hypertension. CONCLUSION: Some heavy metals demonstrate an inverse association with the BP of children and adolescents, particularly notable in groups with fish consumption and older children and adolescents. Future studies are warranted to validate these findings and delve deeper into the interplay of heavy metals. CI - Copyright (c) 2024 Liang, Zhang, Jin, Zhao and Wu. FAU - Liang, Yongzhou AU - Liang Y AD - Department of Pediatric Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Zhang, Minjie AU - Zhang M AD - Department of Pediatric Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Jin, Wenhao AU - Jin W AD - Department of Pediatric Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Zhao, Liqing AU - Zhao L AD - Department of Pediatric Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Wu, Yurong AU - Wu Y AD - Department of Pediatric Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240705 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - 0 (Metals, Heavy) SB - IM MH - Humans MH - Cross-Sectional Studies MH - Adolescent MH - Child MH - *Metals, Heavy/urine MH - Female MH - Male MH - *Blood Pressure/drug effects MH - *Nutrition Surveys MH - *Environmental Exposure/adverse effects/statistics & numerical data MH - United States PMC - PMC11259964 OTO - NOTNLM OT - NHANES OT - blood pressure OT - children OT - heavy metal OT - joint effect COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/07/22 06:43 MHDA- 2024/07/22 06:44 PMCR- 2024/07/05 CRDT- 2024/07/22 05:18 PHST- 2024/04/02 00:00 [received] PHST- 2024/06/27 00:00 [accepted] PHST- 2024/07/22 06:44 [medline] PHST- 2024/07/22 06:43 [pubmed] PHST- 2024/07/22 05:18 [entrez] PHST- 2024/07/05 00:00 [pmc-release] AID - 10.3389/fpubh.2024.1411123 [doi] PST - epublish SO - Front Public Health. 2024 Jul 5;12:1411123. doi: 10.3389/fpubh.2024.1411123. eCollection 2024. PMID- 39033930 OWN - NLM STAT- MEDLINE DCOM- 20241030 LR - 20260527 IS - 1665-2681 (Print) IS - 1665-2681 (Linking) VI - 29 IP - 6 DP - 2024 Nov-Dec TI - Stroop test, Quickstroop, and the 1-min animal naming test for minimal hepatic encephalopathy diagnosis: A multicenter study in Mexico. PG - 101531 LID - S1665-2681(24)00325-9 [pii] LID - 10.1016/j.aohep.2024.101531 [doi] AB - INTRODUCTION AND OBJECTIVES: Although the Psychometric Hepatic Encephalopathy Score (PHES) remains the gold standard in diagnosing minimal hepatic encephalopathy (MHE), its complexity limits its application in clinical practice. While more convenient tests, such as the Stroop test, Quickstroop, and the 1-min animal naming test (ANT-1), have emerged, they haven't been validated in our setting. Our objective was to validate these tests in our population. PATIENTS AND METHODS: This multicenter, observational, descriptive, and cross-sectional study was conducted in three hospitals in northeastern Mexico. MHE was defined as a PHES <-4. We included patients with cirrhosis aged >15 years without a history of overt hepatic encephalopathy. Data regarding sex, age, education, Child-Pugh/MELD-Na scores, etiology of cirrhosis, diabetes, hypertension, obesity, ascites, and clinically significant portal hypertension was collected. Fisher's exact test, Mann-Whitney U test, and receiver operating characteristic (ROC) curves were used for statistical analysis. RESULTS: Of the 121 patients included, 35.5 % were diagnosed with MHE. The presence of MHE was significantly associated with education level, years of study, and scores in the Stroop test, Quickstroop, and ANT-1. The AUROC curves were 77.9 %, 74.6 %, and 72.7 % for the Stroop test, Quickstroop, and ANT-1, respectively. The resulting cut-off points were 218.398 (sensitivity: 74 %; specificity: 74 %), 40.535 (sensitivity: 77 %; specificity: 68 %), and <16 animals (sensitivity: 58 %; specificity: 79 %), respectively. CONCLUSIONS: These tests are valid diagnostic tools for detecting MHE in our population. Their simpler use and applicability could increase the early diagnosis of MHE and prompt primary prophylaxis initiation for overt hepatic encephalopathy. CI - Copyright (c) 2024 Fundacion Clinica Medica Sur, A.C. Published by Elsevier Espana, S.L.U. All rights reserved. FAU - Ortiz-Trevino, Juan F AU - Ortiz-Trevino JF AD - Gastroenterology department, high specialty medical unit (UMAE) No. 25, Northeast National Medical Center, IMSS, Monterrey, Nuevo Leon, P.C. 64320, Mexic. FAU - Kuljacha-Gastelum, Alma L AU - Kuljacha-Gastelum AL AD - Gastroenterology department, high specialty medical unit (UMAE) No. 25, Northeast National Medical Center, IMSS, Monterrey, Nuevo Leon, P.C. 64320, Mexic. Electronic address: almakuljacha@gmail.com. FAU - Tovar-Duran, Alejandro AU - Tovar-Duran A AD - Gastroenterology Department, Zone General Hospital No. 33, IMSS, Monterrey, Nuevo Leon, P.C. 64010, Mexic. FAU - Wade-Isidro, Martha E AU - Wade-Isidro ME AD - Gastroenterology Department, Zone General Hospital No. 17, IMSS, Monterrey, Nuevo Leon, P.C. 64420, Mexic. LA - eng PT - Journal Article PT - Multicenter Study PT - Observational Study PT - Validation Study DEP - 20240719 PL - Mexico TA - Ann Hepatol JT - Annals of hepatology JID - 101155885 SB - IM MH - Humans MH - *Hepatic Encephalopathy/diagnosis/psychology/etiology MH - Female MH - Male MH - Middle Aged MH - Mexico/epidemiology MH - Cross-Sectional Studies MH - Adult MH - Stroop Test MH - Predictive Value of Tests MH - Aged MH - Reproducibility of Results MH - Psychometrics MH - Neuropsychological Tests MH - ROC Curve MH - Liver Cirrhosis/complications/diagnosis OTO - NOTNLM OT - Animal naming test OT - Cirrhosis OT - Hepatic encephalopathy OT - Minimal hepatic encephalopathy OT - Quickstroop OT - Stroop test COIS- Conflicts of interest None. EDAT- 2024/07/22 00:42 MHDA- 2024/10/31 00:27 CRDT- 2024/07/21 19:24 PHST- 2024/05/19 00:00 [received] PHST- 2024/07/04 00:00 [revised] PHST- 2024/07/09 00:00 [accepted] PHST- 2024/10/31 00:27 [medline] PHST- 2024/07/22 00:42 [pubmed] PHST- 2024/07/21 19:24 [entrez] AID - S1665-2681(24)00325-9 [pii] AID - 10.1016/j.aohep.2024.101531 [doi] PST - ppublish SO - Ann Hepatol. 2024 Nov-Dec;29(6):101531. doi: 10.1016/j.aohep.2024.101531. Epub 2024 Jul 19. PMID- 39033923 OWN - NLM STAT- MEDLINE DCOM- 20241121 LR - 20261011 IS - 2212-2672 (Print) IS - 2212-2672 (Linking) VI - 124 IP - 12 DP - 2024 Dec TI - Policy, Systems, and Environmental Strategies to Support Healthy Eating Behaviors in Early Childhood: A Scoping Review of Existing Evaluation Tools. PG - 1614-1645.e23 LID - S2212-2672(24)00720-2 [pii] LID - 10.1016/j.jand.2024.07.160 [doi] AB - BACKGROUND: Policy, systems, and environmental (PSE) change strategies aimed at supporting healthy eating behaviors work to enhance optimal nutrition by making healthy foods more available and accessible in the community. PSE change strategies can complement and strengthen knowledge, skills, and behaviors obtained through individual-level nutrition education. OBJECTIVE: This scoping review aimed to identify existing literature evaluating early childhood (ie, children younger than age 5 years) PSE change strategies supporting healthy eating behaviors and to describe the evaluation tools used to assess the identified PSE change strategies. METHODS: Three databases (PubMed, Cumulated Index in Nursing and Allied Health Literature, and Web of Science) were used to systematically search for articles published between 2013 and 2023 written in English and conducted in the United States that evaluated PSE change strategies supporting healthy eating behaviors in young children (ie, children younger than age 5 years). Two study members conducted the review, discussing and reconciling discrepancies until a consensus was reached for interobserver reliability. RESULTS: Findings from this review identified 48 studies evaluating early childhood PSE change strategies supporting healthy eating behaviors, with 36 studies using 25 PSE-focused evaluation tools to evaluate these strategies. Most tools (80%) assessed PSE change strategies supporting access and availability of healthy food and beverage options in early childhood education settings. Studies did not evaluate child-level outcomes (ie, attitudes, preferences, and behaviors) to showcase improvement of early childhood nutrition. Only 60% of the tools reported evidence of validity or reliability. CONCLUSIONS: Most of the studies identified in this scoping review were aimed to evaluate healthy eating PSE change strategies focused on improving access to and availability of healthy foods and beverages in early childhood education settings. Future research is needed to develop and validate PSE-focused evaluation tools assessing child-level healthy eating practices and behaviors. CI - Copyright (c) 2024 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved. FAU - Varela, Elder Garcia AU - Varela EG AD - Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan. FAU - Shelnutt, Karla P AU - Shelnutt KP AD - Department of Family, Youth & Community Sciences, University of Florida, Gainesville, Florida. FAU - Miller, David M AU - Miller DM AD - Collaborative Assessment and Program Evaluation Services, School of Human Development and Organizational Studies in Education, College of Education, University of Florida, Gainesville, Florida. FAU - Zeldman, Jamie AU - Zeldman J AD - Department of Health Education and Behavior, University of Florida, Gainesville, Florida. FAU - Mobley, Amy R AU - Mobley AR AD - Department of Health Education and Behavior, University of Florida, Gainesville, Florida. Electronic address: amy.mobley@ufl.edu. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Scoping Review DEP - 20240720 PL - United States TA - J Acad Nutr Diet JT - Journal of the Academy of Nutrition and Dietetics JID - 101573920 SB - IM MH - Humans MH - Child, Preschool MH - *Diet, Healthy/methods MH - *Feeding Behavior/psychology MH - Nutrition Policy MH - Health Promotion/methods MH - Infant MH - Female MH - Health Behavior MH - Male MH - United States OTO - NOTNLM OT - Community OT - Health behavior OT - Nutrition education OT - Pediatrics OT - Program evaluation EDAT- 2024/07/22 00:42 MHDA- 2024/11/22 00:22 CRDT- 2024/07/21 19:24 PHST- 2023/05/26 00:00 [received] PHST- 2024/06/24 00:00 [revised] PHST- 2024/07/16 00:00 [accepted] PHST- 2024/11/22 00:22 [medline] PHST- 2024/07/22 00:42 [pubmed] PHST- 2024/07/21 19:24 [entrez] AID - S2212-2672(24)00720-2 [pii] AID - 10.1016/j.jand.2024.07.160 [doi] PST - ppublish SO - J Acad Nutr Diet. 2024 Dec;124(12):1614-1645.e23. doi: 10.1016/j.jand.2024.07.160. Epub 2024 Jul 20. PMID- 39033693 OWN - NLM STAT- MEDLINE DCOM- 20240816 LR - 20260522 IS - 1879-0739 (Electronic) IS - 0271-5317 (Linking) VI - 128 DP - 2024 Aug TI - The relative validity of nutrition assessment methods for estimating infant carotenoid intake differs by assessment tool, nutrient database, and milk carotenoid adjustment method. PG - 38-49 LID - S0271-5317(24)00080-0 [pii] LID - 10.1016/j.nutres.2024.06.003 [doi] AB - Validated carotenoid assessment methods are needed to study infant carotenoid nutrition. This is a secondary analysis of repeated diet assessments of healthy participants collected at 4- (n = 21), 6- (n = 12), and 8- (n = 9) months of age in Houston, TX between April 2019 and June 2020. Intake was assessed with 3 assessment tools, analyzed with 3 nutrient databases, and underwent 3 adjustments to account for milk composition variability. We hypothesized that manual adjustment of milk carotenoid intake based on laboratory measurements would improve the validity of all assessment approaches and that using a database with greater coverage of infant food carotenoid compositions would improve accuracy. Generalized linear mixed models assessed associations between tool, nutrient database, age, and milk carotenoid adjustment variables with carotenoid, energy, fruit, and vegetable intakes. The effect of the number of food diary days on intake estimate precision was evaluated by testing the correlation between intake estimates derived from 1, 3, or 5, vs. 7 days. Visit age influenced energy intake estimates (p = .029), along with assessment tool (p = .020). Estimates of vegetable intake were influenced by tool (p = .009). Combined fruit and vegetable intake differed by nutrient database (p = .007). Carotenoid intake differed by age (p =<.0001), tool (p = .002), and nutrient database (p = .004). A minimum of 3 food diary days strongly correlated (rho = 0.79-1) with reference estimates across ages. Milk carotenoid adjustment was most influential in estimating 4-month olds' carotenoid intake, while nutrient database and tool were important for 6- and 8-month-olds', highlighting the dynamic nature of infant diet assessment validity across feeding stages. CI - Copyright (c) 2024 Elsevier Inc. All rights reserved. FAU - Juneja, Shivanki AU - Juneja S AD - School of Medicine, Baylor College of Medicine, Houston, TX, USA; USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. FAU - Chang, Jocelyn AU - Chang J AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. FAU - Nguyen, Thuy AU - Nguyen T AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. FAU - Castaneda, Robert AU - Castaneda R AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. FAU - O'Connor, Teresia M AU - O'Connor TM AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. FAU - Musaad, Salma AU - Musaad S AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. FAU - Moran, Nancy E AU - Moran NE AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. Electronic address: Nancy.Moran@bcm.edu. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240613 PL - United States TA - Nutr Res JT - Nutrition research (New York, N.Y.) JID - 8303331 RN - 36-88-4 (Carotenoids) RN - 0 (Nutrients) SB - IM MH - *Carotenoids/analysis/administration & dosage MH - Infant MH - Humans MH - Female MH - Male MH - *Nutrition Assessment MH - *Databases, Factual MH - *Diet MH - *Milk/chemistry MH - Reproducibility of Results MH - Animals MH - Diet Records MH - Nutrients/analysis/administration & dosage MH - Vegetables MH - Fruit/chemistry MH - Infant Nutritional Physiological Phenomena MH - Milk, Human/chemistry OTO - NOTNLM OT - 24-hour dietary recall OT - Food OT - Food Diary OT - Human Milk OT - Phytochemicals COIS- Declaration of competing interest The authors have no conflicts of interest to report. EDAT- 2024/07/22 00:42 MHDA- 2024/08/17 15:43 CRDT- 2024/07/21 18:06 PHST- 2024/04/18 00:00 [received] PHST- 2024/06/03 00:00 [revised] PHST- 2024/06/03 00:00 [accepted] PHST- 2024/08/17 15:43 [medline] PHST- 2024/07/22 00:42 [pubmed] PHST- 2024/07/21 18:06 [entrez] AID - S0271-5317(24)00080-0 [pii] AID - 10.1016/j.nutres.2024.06.003 [doi] PST - ppublish SO - Nutr Res. 2024 Aug;128:38-49. doi: 10.1016/j.nutres.2024.06.003. Epub 2024 Jun 13. PMID- 39031494 OWN - NLM STAT- MEDLINE DCOM- 20250415 LR - 20250606 IS - 2050-6414 (Electronic) IS - 2050-6406 (Print) IS - 2050-6406 (Linking) VI - 13 IP - 3 DP - 2025 Apr TI - Assessment of intestinal inflammation via fecal calprotectin for early prediction of adverse outcomes in advanced chronic liver disease. PG - 305-316 LID - 10.1002/ueg2.12633 [doi] AB - BACKGROUND AND AIMS: Intestinal inflammation assessed by fecal calprotectin (F-CAL) in advanced chronic liver disease (ACLD) may represent an early sign of intestinal barrier dysfunction. We aimed to explore the usefulness of F-CAL testing in ACLD in the prediction of adverse outcomes (AO, death, or LT) and refinement of prognostic stratification. PATIENTS AND METHODS: We explored the RH7 cirrhosis registry comprising consecutive hospitalized patients and a control group with data on disease phenotype, demographics, anthropometrics, prognostic indices, and medication. The F-CAL was evaluated on admission and reported in multiples of the upper limit of normal or terciles. Predictive power was tested in the Cox model for AO over 180 days. Additional risk refinement by F-CAL was tested for both groups. RESULTS: We enrolled 263 cases in the study group with a median age of 57.2 years, M/F ratio 167/96, with alcohol, metabolic dysfunction-associated steatotic liver disease, MetALD, and viral etiologies in 72.2%, 9.1, 8.0, 3.4%. The median F-CAL was 3.92 x ULN. The control group comprised 108 cases. The adjusted Cox model confirmed F-CAL (hazard ratio [HR] = 1.05, p < 0.001) and F-CAL terciles (HR = 1.413, p = 0.009) as independent predictors of AO. F-CAL terciles had higher predictive accuracy in CLIF-C-AD<50 (HR = 2.49, p = 0.013) and Child stages A and B (HR = 1.706, p = 0.025), in whom high F-CAL (cut-off >11 x ULN) could identify patients having 2-3 times higher risk of AO. This approach has been validated in the control group. CONCLUSION: Among hospitalized patients with ACLD, F-CAL values were independently proportional to the risk of AO, particularly in early disease stages when high F-CAL values could refine prognostic stratification. CI - (c) 2024 The Author(s). United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology. FAU - Koller, Tomas AU - Koller T AUID- ORCID: 0000-0001-7418-0073 AD - Gastroenterology and Hepatology Subdivision, Department of Internal Medicine 5, Comenius University Faculty of Medicine and University Hospital, Bratislava, Slovakia. FAU - Vrbova, Petra AU - Vrbova P AUID- ORCID: 0000-0003-3512-5711 AD - Gastroenterology and Hepatology Subdivision, Department of Internal Medicine 5, Comenius University Faculty of Medicine and University Hospital, Bratislava, Slovakia. FAU - Kubanek, Natalia AU - Kubanek N AUID- ORCID: 0000-0001-9905-7741 AD - Department of Hepatology, Gastroenterology and Transplantation (HEGITO), Department of Internal Medicine 2, Slovak Medical University and FD Roosevelt Hospital, Banska Bystrica, Slovakia. FAU - Zilincanova, Daniela AU - Zilincanova D AUID- ORCID: 0009-0004-7100-0654 AD - Department of Hepatology, Gastroenterology and Transplantation (HEGITO), Department of Internal Medicine 2, Slovak Medical University and FD Roosevelt Hospital, Banska Bystrica, Slovakia. FAU - Selcanova, Svetlana Adamcova AU - Selcanova SA AUID- ORCID: 0000-0001-8181-1937 AD - Department of Hepatology, Gastroenterology and Transplantation (HEGITO), Department of Internal Medicine 2, Slovak Medical University and FD Roosevelt Hospital, Banska Bystrica, Slovakia. FAU - Havaj, Daniel Jan AU - Havaj DJ AUID- ORCID: 0000-0001-5979-8326 AD - Department of Hepatology, Gastroenterology and Transplantation (HEGITO), Department of Internal Medicine 2, Slovak Medical University and FD Roosevelt Hospital, Banska Bystrica, Slovakia. FAU - Skladany, Lubomir AU - Skladany L AUID- ORCID: 0000-0001-5171-3623 AD - Department of Hepatology, Gastroenterology and Transplantation (HEGITO), Department of Internal Medicine 2, Slovak Medical University and FD Roosevelt Hospital, Banska Bystrica, Slovakia. LA - eng SI - ClinicalTrials.gov/NCT04767945 PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240719 PL - England TA - United European Gastroenterol J JT - United European gastroenterology journal JID - 101606807 RN - 0 (Leukocyte L1 Antigen Complex) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Male MH - Female MH - *Leukocyte L1 Antigen Complex/analysis MH - Middle Aged MH - *Feces/chemistry MH - Prognosis MH - Aged MH - Biomarkers/analysis MH - Predictive Value of Tests MH - Risk Assessment/methods MH - Adult MH - Registries MH - Case-Control Studies MH - Proportional Hazards Models MH - Chronic Disease MH - *Liver Diseases MH - Liver Transplantation/statistics & numerical data MH - *Liver Cirrhosis/mortality/complications MH - Severity of Illness Index PMC - PMC11999047 OTO - NOTNLM OT - advanced chronic liver disease OT - fecal calprotectin OT - liver cirrhosis OT - liver transplantation OT - metabolic dysfunction associated steatotic liver disease COIS- All authors declare having no conflicts of interest regarding the present study. EDAT- 2024/07/20 20:46 MHDA- 2025/04/15 18:24 PMCR- 2024/07/19 CRDT- 2024/07/20 12:03 PHST- 2024/02/24 00:00 [received] PHST- 2024/06/05 00:00 [accepted] PHST- 2025/04/15 18:24 [medline] PHST- 2024/07/20 20:46 [pubmed] PHST- 2024/07/20 12:03 [entrez] PHST- 2024/07/19 00:00 [pmc-release] AID - UEG212633 [pii] AID - 10.1002/ueg2.12633 [doi] PST - ppublish SO - United European Gastroenterol J. 2025 Apr;13(3):305-316. doi: 10.1002/ueg2.12633. Epub 2024 Jul 19. PMID- 39031040 OWN - NLM STAT- MEDLINE DCOM- 20240903 LR - 20260702 IS - 1528-1132 (Electronic) IS - 0009-921X (Print) IS - 0009-921X (Linking) VI - 482 IP - 9 DP - 2024 Sep 1 TI - How Is Variability in Femoral and Acetabular Version Associated With Presentation Among Young Adults With Hip Pain? PG - 1565-1579 LID - 10.1097/CORR.0000000000003076 [doi] AB - BACKGROUND: Acetabular and femoral version contribute to hip pain in patients with femoroacetabular impingement (FAI) or dysplasia. However, definitions and measurement methods of femoral version have varied in different studies, resulting in different "normal" values being used by clinicians for what should be the same anatomic measurement. This could result in discrepant or even inappropriate treatment recommendations. QUESTIONS/PURPOSES: In patients undergoing hip preservation surgery, (1) what is the range of acetabular and femoral version at presentation, and how much do two commonly used measurement techniques (those of Murphy and Reikeras) differ? (2) How are differences in acetabular and femoral version associated with clinical factors and outcomes scores at the time of presentation? METHODS: This was a retrospective analysis of data gathered in a longitudinally maintained database of patients undergoing hip preservation at a tertiary care referral center. Between June 2020 and December 2021, 282 hips in 258 patients were treated for an isolated labral tear (9% [26 hips]), hip dysplasia (21% [59 hips]), FAI (52% [147 hips]), mixed FAI and dysplasia (17% [47 hips]), or pediatric deformity (slipped capital femoral head epiphysis or Perthes disease; 1% [3 hips]) with hip arthroscopy (71% [200 hips]), periacetabular osteotomy (26% [74 hips]), surgical hip dislocation (2.5% [7 hips]), or femoral derotation osteotomy (0.5% [1 hip]). We considered those with complete radiographic data (CT including the pelvis and distal femur) and patient-reported outcome scores as potentially eligible. Exclusion criteria were age younger than 18 or older than 55 years (5 hips, 3 patients), signs of hip osteoarthritis (Tonnis grade >/= 2; 0), pediatric deformity (slipped capital femoral head epiphysis or Perthes disease; 3 hips, 3 patients), previous femoral or acetabular osteotomy (2 hips, 2 patients), avascular necrosis of the femoral head (0), history of neuromuscular disorder (Ehlers-Danlos syndrome; 3 hips, 3 patients) or rheumatoid disease (ankylosing spondylitis; 1 hip, 1 patient), and when CT did not include the knees (19 hips, 19 patients). Based on these criteria, 249 hips in 227 patients were included. Of patients with bilateral symptomatic hips, one side was randomly selected for inclusion, leaving 227 hips in 227 patients for further analysis. The patients' median age (range) was 34 years (19 to 55 years), the median BMI (range) was 27 kg/m 2 (16 to 55 kg/m 2 ), and 63% (144) were female; they were treated with hip arthroscopy (in 74% [168]) or periacetabular osteotomy (in 23% [52]). Patients underwent a CT scan to measure acetabular version and femoral version using the Murphy (low < 10 degrees ; normal: 10 degrees to 25 degrees ; high > 25 degrees ) or Reikeras (low < 5 degrees ; normal: 5 degrees to 20 degrees ; high > 20 degrees ) technique. The McKibbin index was calculated (low: < 20 degrees ; normal: 20 degrees to 50 degrees ; high > 50 degrees ). Based on the central acetabular version and femoral version as measured by Murphy, hips were grouped according to their rotational profile into four groups: unstable rotational profile: high (high acetabular version with high femoral version) or moderate (high acetabular version with normal femoral version or normal acetabular version with high femoral version); normal rotational profile (normal acetabular version with femoral version); compensatory rotational profile (low acetabular version with high femoral version or high acetabular version with low femoral version); and impingement rotational profile (low acetabular version with low femoral version): high (low acetabular version with low femoral version) or moderate (low acetabular version with normal femoral version or normal acetabular version with low femoral version). Radiographic assessments were manually performed on digitized images by two orthopaedic residents, and 25% of randomly selected measurements were repeated by the senior author, a fellowship-trained hip preservation and arthroplasty surgeon. Interobserver and intraobserver reliabilities were calculated using the correlation coefficient with a two-way mixed model, showing excellent agreement for Murphy technique measurements (intraclass correlation coefficient 0.908 [95% confidence interval 0.80 to 0.97]) and Reikeras technique measurements (ICC 0.938 [95% CI 0.81 to 0.97]). Patient-reported measures were recorded using the International Hip Outcome Tool (iHOT-33) (0 to 100; worse to best). RESULTS: The mean acetabular version was 18 degrees +/- 6 degrees , and mean femoral version was 24 degrees +/- 12 degrees using the Murphy technique and 12 degrees +/- 11 degrees with the Reikeras method. Eighty percent (181 of 227) of hips had normal acetabular version, 42% (96 of 227) to 63% (142 to 227) had normal femoral version per Murphy and Reikeras, respectively, and 67% (152 to 227) had a normal McKibbin index. Patients with an impingement profile (low acetabular version or femoral version) were older (39 +/- 9 years) than patients with an unstable (high acetabular version or femoral version; 33 +/- 9 years; p = 0.004), normal (33 +/- 9 years; p = 0.02), or compensatory (high acetabular version with low femoral version or vice versa; 33 +/- 7 years; p = 0.08) rotational profile. Using the Murphy technique, femoral version was 12 degrees greater than with the Reikeras method (R 2 0.85; p < 0.001). There were no differences in iHOT-33 score between different groups (impingement: 32 +/- 17 versus normal 35 +/- 21 versus compensated: 34 +/- 20 versus unstable: 31 +/- 17; p = 0.40). CONCLUSION: Variability in femoral version is twice as large as acetabular version. Patients with an impingement rotational profile were older than patients with a normal, compensatory, or unstable profile, indicating there are other variables not yet fully accounted for that lead to earlier pain and presentation in these groups. Important differences exist between measurement methods. This study shows that different measurement methods for femoral anteversion result in different numbers; if other authors compare their results to those of other studies, they should use equations such as the one suggested in this study. LEVEL OF EVIDENCE: Level III, prognostic study. CI - Copyright (c) 2024 by the Association of Bone and Joint Surgeons. FAU - Verhaegen, Jeroen C F AU - Verhaegen JCF AUID- ORCID: 0000-0003-2254-9451 AD - Division of Orthopaedic Surgery, the Ottawa Hospital, Ottawa, ON, Canada. AD - University Hospital Antwerp, Edegem, Belgium. AD - Orthopaedic Centre Antwerp, AZ Monica, Antwerp, Belgium. FAU - Kerhoulas, Zoe AU - Kerhoulas Z AD - Division of Orthopaedic Surgery, the Ottawa Hospital, Ottawa, ON, Canada. FAU - Burke, Michaela AU - Burke M AD - Division of Orthopaedic Surgery, the Ottawa Hospital, Ottawa, ON, Canada. FAU - Galletta, Claudia AU - Galletta C AD - Michele e Pietro Ferrero Hospital, Verduno, Italy. FAU - Wilkin, Geoffrey AU - Wilkin G AUID- ORCID: 0000-0002-9807-7916 AD - Division of Orthopaedic Surgery, the Ottawa Hospital, Ottawa, ON, Canada. FAU - Smit, Kevin AU - Smit K AD - Division of Orthopaedic Surgery, the Ottawa Hospital, Ottawa, ON, Canada. AD - Division of Orthopaedic Surgery, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada. FAU - Carsen, Sasha AU - Carsen S AD - Division of Orthopaedic Surgery, the Ottawa Hospital, Ottawa, ON, Canada. AD - Division of Orthopaedic Surgery, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada. FAU - Beaule, Paul E AU - Beaule PE AD - Division of Orthopaedic Surgery, the Ottawa Hospital, Ottawa, ON, Canada. FAU - Grammatopoulos, George AU - Grammatopoulos G AUID- ORCID: 0000-0002-7444-9498 AD - Division of Orthopaedic Surgery, the Ottawa Hospital, Ottawa, ON, Canada. LA - eng PT - Journal Article DEP - 20240507 PL - United States TA - Clin Orthop Relat Res JT - Clinical orthopaedics and related research JID - 0075674 SB - IM MH - Humans MH - Female MH - Male MH - *Acetabulum/surgery/diagnostic imaging MH - Retrospective Studies MH - *Femoracetabular Impingement/surgery/diagnostic imaging/physiopathology MH - Young Adult MH - Adult MH - *Femur/diagnostic imaging/surgery MH - Adolescent MH - Arthralgia/surgery/etiology/physiopathology/diagnosis MH - Hip Joint/surgery/diagnostic imaging/physiopathology MH - Databases, Factual PMC - PMC11343531 COIS- Each author certifies that there are no funding or commercial associations (consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article related to the author or any immediate family members. All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research(R) editors and board members are on file with the publication and can be viewed on request. EDAT- 2024/07/20 20:44 MHDA- 2024/09/03 18:43 PMCR- 2025/09/01 CRDT- 2024/07/20 08:12 PHST- 2023/11/08 00:00 [received] PHST- 2024/03/12 00:00 [accepted] PHST- 2024/09/03 18:43 [medline] PHST- 2024/07/20 20:44 [pubmed] PHST- 2024/07/20 08:12 [entrez] PHST- 2025/09/01 00:00 [pmc-release] AID - 00003086-202409000-00011 [pii] AID - CORR-D-23-01392 [pii] AID - 10.1097/CORR.0000000000003076 [doi] PST - ppublish SO - Clin Orthop Relat Res. 2024 Sep 1;482(9):1565-1579. doi: 10.1097/CORR.0000000000003076. Epub 2024 May 7. PMID- 39030071 OWN - NLM STAT- MEDLINE DCOM- 20250724 LR - 20250724 IS - 1552-3918 (Electronic) IS - 0163-2787 (Linking) VI - 48 IP - 3 DP - 2025 Sep TI - Psychometric Properties of a Wellness Behavior Rating Scale for Young Adolescents. PG - 320-329 LID - 10.1177/01632787241263372 [doi] AB - We examined the psychometric properties of the Physical Activity, Nutrition, and Technology (PANT) survey, developed by researchers to track weight management behaviors among youth. Data from 2,039 middle school students (M age = 12.4, SD = .5; 51.4% girls) were analyzed to explore and then confirm the factor structure of the PANT survey. We also examined the bivariate associations between the PANT survey, body mass index (BMI), and the Progressive Aerobic Cardiorespiratory Endurance Run (PACER). Results suggest that the PANT survey is comprised of two factors-Physical Activity and Healthy Choices-each with adequate internal consistency (alpha = .79 and 0.86, respectively). The Physical Activity subscale appears to be significantly associated with both z-BMI (r = -0.10, p < .001) and the PACER (r = 0.33, p < .001) in the anticipated directions, but the criterion validity of the Healthy Choices subscale is less clear. We discuss these findings and explore future directions for developing meaningful self-report wellness behavior scales for youth. FAU - Mirabelli, Karlie M AU - Mirabelli KM AD - Wellington Counseling Group, USA. RINGGOLD: 575956 FAU - Schultz, Brandon K AU - Schultz BK AUID- ORCID: 0000-0001-9130-6723 AD - East Carolina University, USA. RINGGOLD: 3627 FAU - Schoemann, Alexander M AU - Schoemann AM AD - East Carolina University, USA. RINGGOLD: 3627 FAU - Bell, Sequoyah R AU - Bell SR AD - East Carolina University, USA. RINGGOLD: 3627 FAU - Lazorick, Suzanne AU - Lazorick S AD - East Carolina University, USA. RINGGOLD: 3627 LA - eng PT - Journal Article DEP - 20240719 PL - United States TA - Eval Health Prof JT - Evaluation & the health professions JID - 7805992 SB - IM MH - Humans MH - Female MH - Psychometrics MH - Male MH - Adolescent MH - *Health Behavior MH - *Exercise MH - Child MH - Body Mass Index MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - Self Report OTO - NOTNLM OT - education OT - health psychology OT - obesity OT - scale OT - youth COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2024/07/20 10:43 MHDA- 2025/07/24 06:30 CRDT- 2024/07/19 22:22 PHST- 2025/07/24 06:30 [medline] PHST- 2024/07/20 10:43 [pubmed] PHST- 2024/07/19 22:22 [entrez] AID - 10.1177/01632787241263372 [doi] PST - ppublish SO - Eval Health Prof. 2025 Sep;48(3):320-329. doi: 10.1177/01632787241263372. Epub 2024 Jul 19. PMID- 39029330 OWN - NLM STAT- MEDLINE DCOM- 20240928 LR - 20260307 IS - 1878-9307 (Electronic) IS - 1878-9293 (Print) IS - 1878-9293 (Linking) VI - 69 DP - 2024 Oct TI - UNITY: A low-field magnetic resonance neuroimaging initiative to characterize neurodevelopment in low and middle-income settings. PG - 101397 LID - S1878-9293(24)00058-6 [pii] LID - 10.1016/j.dcn.2024.101397 [doi] LID - 101397 AB - Measures of physical growth, such as weight and height have long been the predominant outcomes for monitoring child health and evaluating interventional outcomes in public health studies, including those that may impact neurodevelopment. While physical growth generally reflects overall health and nutritional status, it lacks sensitivity and specificity to brain growth and developing cognitive skills and abilities. Psychometric tools, e.g., the Bayley Scales of Infant and Toddler Development, may afford more direct assessment of cognitive development but they require language translation, cultural adaptation, and population norming. Further, they are not always reliable predictors of future outcomes when assessed within the first 12-18 months of a child's life. Neuroimaging may provide more objective, sensitive, and predictive measures of neurodevelopment but tools such as magnetic resonance (MR) imaging are not readily available in many low and middle-income countries (LMICs). MRI systems that operate at lower magnetic fields (< 100mT) may offer increased accessibility, but their use for global health studies remains nascent. The UNITY project is envisaged as a global partnership to advance neuroimaging in global health studies. Here we describe the UNITY project, its goals, methods, operating procedures, and expected outcomes in characterizing neurodevelopment in sub-Saharan Africa and South Asia. CI - Copyright (c) 2024. Published by Elsevier Ltd. FAU - Abate, F AU - Abate F AD - Addis Continental Institute of Public Health, Addis Ababa, Ethiopia; Waisman Research Center, Madison, WI, USA. FAU - Adu-Amankwah, A AU - Adu-Amankwah A AD - Korle-Bu Teaching Hospital, Accra, Ghana; Waisman Research Center, Madison, WI, USA. FAU - Ae-Ngibise, K A AU - Ae-Ngibise KA AD - Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Bono East Region, Ghana; Waisman Research Center, Madison, WI, USA. FAU - Agbokey, F AU - Agbokey F AD - Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Bono East Region, Ghana; Waisman Research Center, Madison, WI, USA. FAU - Agyemang, V A AU - Agyemang VA AD - Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Bono East Region, Ghana; Waisman Research Center, Madison, WI, USA. FAU - Agyemang, C T AU - Agyemang CT AD - Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Bono East Region, Ghana; Waisman Research Center, Madison, WI, USA. FAU - Akgun, C AU - Akgun C AD - flywheel.io Minneapolis, MN, USA; Waisman Research Center, Madison, WI, USA. FAU - Ametepe, J AU - Ametepe J AD - Cardiff University Brain Research Imaging Center, Cardiff University, Cardiff, UK; Waisman Research Center, Madison, WI, USA. FAU - Arichi, T AU - Arichi T AD - Centre for the Developing Brain, Kings College London, London, UK; Waisman Research Center, Madison, WI, USA. FAU - Asante, K P AU - Asante KP AD - Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Bono East Region, Ghana; Waisman Research Center, Madison, WI, USA. FAU - Balaji, S AU - Balaji S AD - Dept. of Neurology, University of British Columbia, Vancouver, BC, Canada; Waisman Research Center, Madison, WI, USA. FAU - Baljer, L AU - Baljer L AD - Centre for Neuroimaging Sciences, King's College London, London, UK; Waisman Research Center, Madison, WI, USA. FAU - Basser, P J AU - Basser PJ AD - National Institutes of Health, Washington, DC, USA; Waisman Research Center, Madison, WI, USA. FAU - Beauchemin, J AU - Beauchemin J AD - Advanced Baby Imaging Lab, Providence, RI, USA; Waisman Research Center, Madison, WI, USA. FAU - Bennallick, C AU - Bennallick C AD - Centre for Neuroimaging Sciences, King's College London, London, UK; Waisman Research Center, Madison, WI, USA. FAU - Berhane, Y AU - Berhane Y AD - Addis Continental Institute of Public Health, Addis Ababa, Ethiopia; Waisman Research Center, Madison, WI, USA. FAU - Boateng-Mensah, Y AU - Boateng-Mensah Y AD - Korle-Bu Teaching Hospital, Accra, Ghana; Waisman Research Center, Madison, WI, USA. FAU - Bourke, N J AU - Bourke NJ AD - Centre for Neuroimaging Sciences, King's College London, London, UK; Waisman Research Center, Madison, WI, USA. FAU - Bradford, L AU - Bradford L AD - Division of Developmental Paediatrics, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and the Neuroscience Institute, University of Cape Town, Cape Town, South Africa; Waisman Research Center, Madison, WI, USA. FAU - Bruchhage, Mmk AU - Bruchhage M AD - Dept. of Psychology, Stavanger University, Norway; Waisman Research Center, Madison, WI, USA. FAU - Lorente, R Cano AU - Lorente RC AD - Advanced Baby Imaging Lab, Providence, RI, USA; Waisman Research Center, Madison, WI, USA. FAU - Cawley, P AU - Cawley P AD - Centre for the Developing Brain, Kings College London, London, UK; Waisman Research Center, Madison, WI, USA. FAU - Cercignani, M AU - Cercignani M AD - Cardiff University Brain Research Imaging Center, Cardiff University, Cardiff, UK; Waisman Research Center, Madison, WI, USA. FAU - D Sa, V AU - D Sa V AD - Advanced Baby Imaging Lab, Providence, RI, USA; Waisman Research Center, Madison, WI, USA. FAU - Canha, A de AU - Canha A AD - Institute for Cellular and Molecular Medicine, Department of Medical Immunology, University of Pretoria, Pretoria, South Africa; Waisman Research Center, Madison, WI, USA. FAU - Navarro, N de AU - Navarro N AD - Collective Minds Radiology, Sweden; Waisman Research Center, Madison, WI, USA. FAU - Dean, D C 3rd AU - Dean DC 3rd AD - School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA; Waisman Research Center, Madison, WI, USA. FAU - Delarosa, J AU - Delarosa J AD - PATH, Seattle, WA, USA; Waisman Research Center, Madison, WI, USA. FAU - Donald, K A AU - Donald KA AD - Division of Developmental Paediatrics, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and the Neuroscience Institute, University of Cape Town, Cape Town, South Africa; Waisman Research Center, Madison, WI, USA. FAU - Dvorak, A AU - Dvorak A AD - Dept. of Neurology, University of British Columbia, Vancouver, BC, Canada; Waisman Research Center, Madison, WI, USA. FAU - Edwards, A D AU - Edwards AD AD - Centre for the Developing Brain, Kings College London, London, UK; Waisman Research Center, Madison, WI, USA. FAU - Field, D AU - Field D AD - Collective Minds Radiology, Sweden; Waisman Research Center, Madison, WI, USA. FAU - Frail, H AU - Frail H AD - Hyperfine.io, Guilford, CT, USA; Waisman Research Center, Madison, WI, USA. FAU - Freeman, B AU - Freeman B AD - University of North Carolina, Department of Obstetrics and Gynecology, Chapel Hill, USA; Waisman Research Center, Madison, WI, USA. FAU - George, T AU - George T AD - Department of Radiology, Faculty of Health Sciences, Chris Hani Baragwanath Academic Hospital, University; Waisman Research Center, Madison, WI, USA. FAU - Gholam, J AU - Gholam J AD - Cardiff University Brain Research Imaging Center, Cardiff University, Cardiff, UK; Waisman Research Center, Madison, WI, USA. FAU - Guerrero-Gonzalez, J AU - Guerrero-Gonzalez J AD - School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA; Waisman Research Center, Madison, WI, USA. FAU - Hajnal, J V AU - Hajnal JV AD - Centre for the Developing Brain, Kings College London, London, UK; Waisman Research Center, Madison, WI, USA. FAU - Haque, R AU - Haque R AD - International Centre for Diarrheal Disease Research, Bangladesh (Icddr,b), Dhaka, Bangladesh; Waisman Research Center, Madison, WI, USA. FAU - Hollander, W AU - Hollander W AD - CaliberMRI, Boulder CO USA; Waisman Research Center, Madison, WI, USA. FAU - Hoodbhoy, Z AU - Hoodbhoy Z AD - Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan; Waisman Research Center, Madison, WI, USA. FAU - Huentelman, M AU - Huentelman M AD - TGen, Phoenix, AZ, USA; Waisman Research Center, Madison, WI, USA. FAU - Jafri, S K AU - Jafri SK AD - Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan; Waisman Research Center, Madison, WI, USA. FAU - Jones, D K AU - Jones DK AD - Cardiff University Brain Research Imaging Center, Cardiff University, Cardiff, UK; Waisman Research Center, Madison, WI, USA. FAU - Joubert, F AU - Joubert F AD - Centre for Bioinformatics and Computational Biology, Department of Biochemistry, Microbiology and Genetics, University of Pretoria, Pretoria, South Africa; Waisman Research Center, Madison, WI, USA. FAU - Karaulanov, T AU - Karaulanov T AD - CaliberMRI, Boulder CO USA; Waisman Research Center, Madison, WI, USA. FAU - Kasaro, M P AU - Kasaro MP AD - University of North Carolina - Global Projects Zambia, Lusaka, Zambia; Waisman Research Center, Madison, WI, USA. FAU - Knackstedt, S AU - Knackstedt S AD - PATH, Seattle, WA, USA; Waisman Research Center, Madison, WI, USA. FAU - Kolind, S AU - Kolind S AD - Dept. of Neurology, University of British Columbia, Vancouver, BC, Canada; Waisman Research Center, Madison, WI, USA. FAU - Koshy, B AU - Koshy B AD - Developmental Paediatrics, Christian Medical College, Vellore, India; Waisman Research Center, Madison, WI, USA. FAU - Kravitz, R AU - Kravitz R AD - International Society for Magnetic Resonance in Medicine, San Fransisco, CA, USA; Waisman Research Center, Madison, WI, USA. FAU - Lafayette, S Lecurieux AU - Lafayette SL AD - Centre for the Developing Brain, Kings College London, London, UK; Waisman Research Center, Madison, WI, USA. FAU - Lee, A C AU - Lee AC AD - Brigham and Women's Hospital, Department of Pediatrics; Harvard Medical School; Boston, MA, USA; Waisman Research Center, Madison, WI, USA. FAU - Lena, B AU - Lena B AD - Dept. of Radiology, Leiden University, Leiden, the Netherlands; Waisman Research Center, Madison, WI, USA. FAU - Lepore, N AU - Lepore N AD - Dept. of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Waisman Research Center, Madison, WI, USA. FAU - Linguraru, M AU - Linguraru M AD - Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC, USA; Waisman Research Center, Madison, WI, USA. FAU - Ljungberg, E AU - Ljungberg E AD - Medical Radiation Physics, Lund University, Lund, Sweden; Waisman Research Center, Madison, WI, USA. FAU - Lockart, Z AU - Lockart Z AD - Department of Radiology, Faculty of Health Sciences, Steve Biko Academic Hospital, University of Pretoria, Pretoria, South Africa; Waisman Research Center, Madison, WI, USA. FAU - Loth, E AU - Loth E AD - Department of Forensic and Neurodevelopemental Science, Institute of Psychatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Waisman Research Center, Madison, WI, USA. FAU - Mannam, P AU - Mannam P AD - Developmental Paediatrics, Christian Medical College, Vellore, India; Waisman Research Center, Madison, WI, USA. FAU - Masemola, K M AU - Masemola KM AD - Department of Paediatrics and Child Health, Kalafong Hospital and Faculty of Health Sciences, University of Pretoria, South Africa; Waisman Research Center, Madison, WI, USA. FAU - Moran, R AU - Moran R AD - Centre for Neuroimaging Sciences, King's College London, London, UK; Waisman Research Center, Madison, WI, USA. FAU - Murphy, D AU - Murphy D AD - Department of Forensic and Neurodevelopemental Science, Institute of Psychatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Waisman Research Center, Madison, WI, USA. FAU - Nakwa, F L AU - Nakwa FL AD - Department of Paediatrics and Child Health, Chris Hani Baragwanath Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Waisman Research Center, Madison, WI, USA. FAU - Nankabirwa, V AU - Nankabirwa V AD - Department of Epidemiology and Biostatistics, School of Public Health, Makerere University. Kampala, Uganda; Waisman Research Center, Madison, WI, USA. FAU - Nelson, C A AU - Nelson CA AD - Laboratories of Cognitive Neuroscience, Division of Developmental Medicine, Department of Medicine, Boston Children's Hospital, Boston, MA, USA; Waisman Research Center, Madison, WI, USA. FAU - North, K AU - North K AD - Brigham and Women's Hospital, Department of Pediatrics; Harvard Medical School; Boston, MA, USA; Waisman Research Center, Madison, WI, USA. FAU - Nyame, S AU - Nyame S AD - Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Bono East Region, Ghana; Waisman Research Center, Madison, WI, USA. FAU - O Halloran, R AU - O Halloran R AD - Hyperfine.io, Guilford, CT, USA; Waisman Research Center, Madison, WI, USA. FAU - O'Muircheartaigh, J AU - O'Muircheartaigh J AD - Centre for the Developing Brain, Kings College London, London, UK; Waisman Research Center, Madison, WI, USA. FAU - Oakley, B F AU - Oakley BF AD - Department of Forensic and Neurodevelopemental Science, Institute of Psychatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Waisman Research Center, Madison, WI, USA. FAU - Odendaal, H AU - Odendaal H AD - Dept Obstet Gynaecol, Stellenbosch University, South Africa; Waisman Research Center, Madison, WI, USA. FAU - Ongeti, C M AU - Ongeti CM AD - Jaramogi Oginga Odinga Teaching and Referral Hospital, Kisumu, Kenya; Waisman Research Center, Madison, WI, USA. FAU - Onyango, D AU - Onyango D AD - Jaramogi Oginga Odinga Teaching and Referral Hospital, Kisumu, Kenya; Waisman Research Center, Madison, WI, USA. FAU - Oppong, S A AU - Oppong SA AD - Korle-Bu Teaching Hospital, Accra, Ghana; Waisman Research Center, Madison, WI, USA. FAU - Padormo, F AU - Padormo F AD - Hyperfine.io, Guilford, CT, USA; Waisman Research Center, Madison, WI, USA. FAU - Parvez, D AU - Parvez D AD - Collective Minds Radiology, Sweden; Waisman Research Center, Madison, WI, USA. FAU - Paus, T AU - Paus T AD - Departments of Psychiatry and Neuroscience, Faculty of Medicine and Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Quebec, Canada; Waisman Research Center, Madison, WI, USA. FAU - Pepper, M S AU - Pepper MS AD - Institute for Cellular and Molecular Medicine, Department of Medical Immunology, University of Pretoria, Pretoria, South Africa; Waisman Research Center, Madison, WI, USA. FAU - Phiri, K S AU - Phiri KS AD - Training and Research Unit of Excellence (TRUE), Zomba Malawi; Waisman Research Center, Madison, WI, USA. FAU - Poorman, M AU - Poorman M AD - Hyperfine.io, Guilford, CT, USA; Waisman Research Center, Madison, WI, USA. FAU - Ringshaw, J E AU - Ringshaw JE AD - Division of Developmental Paediatrics, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and the Neuroscience Institute, University of Cape Town, Cape Town, South Africa; Waisman Research Center, Madison, WI, USA. FAU - Rogers, J AU - Rogers J AD - Hyperfine.io, Guilford, CT, USA; Waisman Research Center, Madison, WI, USA. FAU - Rutherford, M AU - Rutherford M AD - Centre for the Developing Brain, Kings College London, London, UK; Waisman Research Center, Madison, WI, USA. FAU - Sabir, H AU - Sabir H AD - Experimental Neonatology, University Hospitals Bonn, Bonn, Germany; Waisman Research Center, Madison, WI, USA. FAU - Sacolick, L AU - Sacolick L AD - Hyperfine.io, Guilford, CT, USA; Waisman Research Center, Madison, WI, USA. FAU - Seal, M AU - Seal M AD - Murdoch Children's Research Institute, Melbourne, AUS; Waisman Research Center, Madison, WI, USA. FAU - Sekoli, M L AU - Sekoli ML AD - Institute for Cellular and Molecular Medicine, Department of Medical Immunology, University of Pretoria, Pretoria, South Africa; Waisman Research Center, Madison, WI, USA. FAU - Shama, T AU - Shama T AD - International Centre for Diarrheal Disease Research, Bangladesh (Icddr,b), Dhaka, Bangladesh; Waisman Research Center, Madison, WI, USA. FAU - Siddiqui, K AU - Siddiqui K AD - Hyperfine.io, Guilford, CT, USA; Waisman Research Center, Madison, WI, USA. FAU - Sindano, N AU - Sindano N AD - University of North Carolina - Global Projects Zambia, Lusaka, Zambia; Waisman Research Center, Madison, WI, USA. FAU - Spelke, M B AU - Spelke MB AD - University of North Carolina, Department of Obstetrics and Gynecology, Chapel Hill, USA; Waisman Research Center, Madison, WI, USA. FAU - Springer, P E AU - Springer PE AD - Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; Waisman Research Center, Madison, WI, USA. FAU - Suleman, F E AU - Suleman FE AD - Department of Radiology, Faculty of Health Sciences, Kalafong Hospital, University of Pretoria, Pretoria, South Africa; Waisman Research Center, Madison, WI, USA. FAU - Sundgren, P C AU - Sundgren PC AD - Section of Diagnostic Radiology,Department of Clinical Sciences Lund, Lund University, Lund, Sweden; Waisman Research Center, Madison, WI, USA. FAU - Teixeira, R AU - Teixeira R AD - Hyperfine.io, Guilford, CT, USA; Waisman Research Center, Madison, WI, USA. FAU - Terekegn, W AU - Terekegn W AD - Addis Continental Institute of Public Health, Addis Ababa, Ethiopia; Waisman Research Center, Madison, WI, USA. FAU - Traughber, M AU - Traughber M AD - Hyperfine.io, Guilford, CT, USA; Waisman Research Center, Madison, WI, USA. FAU - Tuuli, M G AU - Tuuli MG AD - Jaramogi Oginga Odinga Teaching and Referral Hospital, Kisumu, Kenya; Waisman Research Center, Madison, WI, USA. FAU - Rensburg, J van AU - Rensburg JV AD - Institute for Cellular and Molecular Medicine, Department of Medical Immunology, University of Pretoria, Pretoria, South Africa; Waisman Research Center, Madison, WI, USA. FAU - Vasa, F AU - Vasa F AD - Centre for Neuroimaging Sciences, King's College London, London, UK; Waisman Research Center, Madison, WI, USA. FAU - Velaphi, S AU - Velaphi S AD - Department of Paediatrics and Child Health, Chris Hani Baragwanath Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Waisman Research Center, Madison, WI, USA. FAU - Velasco, P AU - Velasco P AD - flywheel.io Minneapolis, MN, USA; Waisman Research Center, Madison, WI, USA. FAU - Viljoen, I M AU - Viljoen IM AD - Department of Radiology, Faculty of Health Sciences, Chris Hani Baragwanath Academic Hospital, University; Waisman Research Center, Madison, WI, USA. FAU - Vokhiwa, M AU - Vokhiwa M AD - Training and Research Unit of Excellence (TRUE), Zomba Malawi; Waisman Research Center, Madison, WI, USA. FAU - Webb, A AU - Webb A AD - Dept. of Radiology, Leiden University, Leiden, the Netherlands; Waisman Research Center, Madison, WI, USA. FAU - Weiant, C AU - Weiant C AD - CaliberMRI, Boulder CO USA; Waisman Research Center, Madison, WI, USA. FAU - Wiley, N AU - Wiley N AD - Dept. of Neurology, University of British Columbia, Vancouver, BC, Canada; Waisman Research Center, Madison, WI, USA. FAU - Wintermark, P AU - Wintermark P AD - Division of Newborn Medicine, Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, QC, Canada; Waisman Research Center, Madison, WI, USA. FAU - Yibetal, K AU - Yibetal K AD - Addis Continental Institute of Public Health, Addis Ababa, Ethiopia; Waisman Research Center, Madison, WI, USA. FAU - Deoni, Scl AU - Deoni S AD - Bill & Melinda Gates Foundation, MNCH D&T, Seattle, WA, USA; Waisman Research Center, Madison, WI, USA. FAU - Williams, Scr AU - Williams S AD - Centre for Neuroimaging Sciences, King's College London, London, UK; Waisman Research Center, Madison, WI, USA. Electronic address: steve.williams@kcl.ac.uk. LA - eng GR - R01 HD107475/HD/NICHD NIH HHS/United States GR - 104943/Z/14/Z/WT_/Wellcome Trust/United Kingdom GR - 096646/Z/11/Z/WT_/Wellcome Trust/United Kingdom GR - K01 TW012426/TW/FIC NIH HHS/United States GR - R01 HD106106/HD/NICHD NIH HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240531 PL - Netherlands TA - Dev Cogn Neurosci JT - Developmental cognitive neuroscience JID - 101541838 SB - IM MH - Humans MH - *Magnetic Resonance Imaging/methods MH - *Neuroimaging/methods MH - *Child Development/physiology MH - *Developing Countries MH - *Brain/growth & development/diagnostic imaging MH - Infant MH - Child, Preschool MH - Child MH - Male MH - Female MH - Poverty PMC - PMC11315107 OTO - NOTNLM OT - Child Health OT - Environmental Adversity OT - Global Health OT - Healthy Development OT - Low Field Magnetic Resonance Imaging OT - Neurodevelopment COIS- Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: H Frail, R O'Halloran, F Padormo, M Poorman, J Rogers, L Sacolick, K Siddiqui, R Teixeira, M Traughber are employees of Hyperfine.io W Hollander, T. Karaulanov, and C Weiant are employees of CaliberMRI. C Akgun, and P Velasco are employees of Flywheel.io EDAT- 2024/07/20 10:42 MHDA- 2024/09/29 00:42 PMCR- 2024/05/31 CRDT- 2024/07/19 18:12 PHST- 2023/12/20 00:00 [received] PHST- 2024/05/28 00:00 [revised] PHST- 2024/05/30 00:00 [accepted] PHST- 2024/09/29 00:42 [medline] PHST- 2024/07/20 10:42 [pubmed] PHST- 2024/07/19 18:12 [entrez] PHST- 2024/05/31 00:00 [pmc-release] AID - S1878-9293(24)00058-6 [pii] AID - 101397 [pii] AID - 10.1016/j.dcn.2024.101397 [doi] PST - ppublish SO - Dev Cogn Neurosci. 2024 Oct;69:101397. doi: 10.1016/j.dcn.2024.101397. Epub 2024 May 31. PMID- 39028885 OWN - NLM STAT- MEDLINE DCOM- 20250317 LR - 20260826 IS - 1527-3350 (Electronic) IS - 0270-9139 (Linking) VI - 81 IP - 4 DP - 2025 Apr 1 TI - Development and validation of pFIB scores for exclusion of significant liver fibrosis in pediatric MASLD. PG - 1276-1287 LID - 10.1097/HEP.0000000000001016 [doi] AB - BACKGROUND AND AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent pediatric liver disease, yet accurate risk scores for referral of children/adolescents with suspected clinically significant liver fibrosis are currently lacking. APPROACH AND RESULTS: Clinical and biochemical variables were collected in a prospective cohort of 327 children and adolescents with severe obesity, in whom liver fibrosis was evaluated by transient elastography. Logistic regression was performed to establish continuous (pFIB-c) and simplified (pFIB-6) diagnostic scores that accurately exclude significant (>/=F2) fibrosis. Performance for each was compared to established noninvve fibrosis scores. These scores were validated in elastography (n=504) and multiple biopsy-proven MASLD (n=261) cohorts. Patient sex, ethnicity, weight z-score, homeostatic model assessment of insulin resistance index, ALT, and presence of hypertension were included in the scores. The pFIB-c and pFIB-6 exhibited good discriminatory capacity (c-statistic of 0.839 and 0.826), outperforming existing indices. Negative predictive values were >90% for both scores in the derivation and elastography validation cohorts. Performance in the histological cohorts varied (AUROCs for the pFIB-c between 0.710 and 0.770), as the scores were less accurate when applied to populations in tertiary referral centers characterized by a high prevalence of significant fibrosis and high ALT levels. CONCLUSIONS: Analyzing several cohorts totaling approximately 1100 children and adolescents, we developed novel risk scores incorporating readily available clinical variables. In accordance with the aim of excluding pediatric MASLD-associated fibrosis, the scores performed better in nonselected cohorts of children and adolescents living with obesity than in patients referred to tertiary liver units. CI - Copyright (c) 2024 American Association for the Study of Liver Diseases. FAU - Lefere, Sander AU - Lefere S AUID- ORCID: 0000-0001-5734-3467 AD - Hepatology Research Unit, Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium. AD - Liver Research Center Ghent, Ghent University Hospital, Ghent, Belgium. FAU - Mosca, Antonella AU - Mosca A AUID- ORCID: 0000-0001-9646-7462 AD - Hepatogastroenterology, Nutrition, Digestive Endoscopy and Liver Transplant Unit, Bambino Gesu Children's Hospital, Rome, Italy. FAU - Hudert, Christian AU - Hudert C AUID- ORCID: 0000-0002-3642-0838 AD - Department of Pediatric Gastroenterology, Nephrology and Metabolic Medicine, Charite - Universitatsmedizin Berlin, Berlin, Germany. FAU - Dupont, Ellen AU - Dupont E AD - Zeepreventorium, De Haan, Belgium. FAU - Fitzpatrick, Emer AU - Fitzpatrick E AUID- ORCID: 0000-0002-1364-5305 AD - Paediatric Liver, GI and Nutrition Centre, King's College Hospital, London, United Kingdom. AD - Department of Gastroenterology, Hepatology and Nutrition, Children's Health Ireland and University College Dublin, Ireland. FAU - Kyrana, Eirini AU - Kyrana E AUID- ORCID: 0000-0002-4696-4855 AD - Institute of Liver Studies, King's College Hospital, London, United Kingdom. FAU - Dhawan, Anil AU - Dhawan A AUID- ORCID: 0000-0002-4942-0845 AD - Paediatric Liver, GI and Nutrition Centre, King's College Hospital, London, United Kingdom. FAU - Kalveram, Laura AU - Kalveram L AUID- ORCID: 0000-0002-4687-7882 AD - Department of Pediatric Gastroenterology, Nephrology and Metabolic Medicine, Charite - Universitatsmedizin Berlin, Berlin, Germany. FAU - Pietrobattista, Andrea AU - Pietrobattista A AUID- ORCID: 0000-0002-4426-0395 AD - Hepatogastroenterology, Nutrition, Digestive Endoscopy and Liver Transplant Unit, Bambino Gesu Children's Hospital, Rome, Italy. FAU - Geerts, Anja AU - Geerts A AUID- ORCID: 0000-0002-2218-9081 AD - Hepatology Research Unit, Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium. AD - Liver Research Center Ghent, Ghent University Hospital, Ghent, Belgium. FAU - De Bruyne, Ruth AU - De Bruyne R AUID- ORCID: 0000-0002-5623-3300 AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Ghent University, Ghent, Belgium. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20240719 PL - United States TA - Hepatology JT - Hepatology (Baltimore, Md.) JID - 8302946 SB - IM MH - Humans MH - Child MH - Male MH - Adolescent MH - *Liver Cirrhosis/diagnosis/etiology/pathology MH - Female MH - Elasticity Imaging Techniques MH - Prospective Studies MH - *Fatty Liver/complications/diagnosis MH - Severity of Illness Index MH - *Pediatric Obesity/complications MH - Liver/pathology MH - Risk Assessment/methods MH - Predictive Value of Tests EDAT- 2024/07/19 18:42 MHDA- 2025/03/17 18:31 CRDT- 2024/07/19 15:13 PHST- 2024/04/03 00:00 [received] PHST- 2024/07/01 00:00 [accepted] PHST- 2025/03/17 18:31 [medline] PHST- 2024/07/19 18:42 [pubmed] PHST- 2024/07/19 15:13 [entrez] AID - 01515467-202504000-00021 [pii] AID - 10.1097/HEP.0000000000001016 [doi] PST - ppublish SO - Hepatology. 2025 Apr 1;81(4):1276-1287. doi: 10.1097/HEP.0000000000001016. Epub 2024 Jul 19. PMID- 39026322 OWN - NLM STAT- MEDLINE DCOM- 20240719 LR - 20241202 IS - 1741-7015 (Electronic) IS - 1741-7015 (Linking) VI - 22 IP - 1 DP - 2024 Jul 19 TI - Unraveling the metabolomic architecture of autism in a large Danish population-based cohort. PG - 302 LID - 10.1186/s12916-024-03516-7 [doi] LID - 302 AB - BACKGROUND: The prevalence of autism in Denmark has been increasing, reaching 1.65% among 10-year-old children, and similar trends are seen elsewhere. Although there are several factors associated with autism, including genetic, environmental, and prenatal factors, the molecular etiology of autism is largely unknown. Here, we use untargeted metabolomics to characterize the neonatal metabolome from dried blood spots collected shortly after birth. METHODS: We analyze the metabolomic profiles of a subset of a large Danish population-based cohort (iPSYCH2015) consisting of over 1400 newborns, who later are diagnosed with autism and matching controls and in two Swedish population-based cohorts comprising over 7000 adult participants. Mass spectrometry analysis was performed by a timsTOF Pro operated in QTOF mode, using data-dependent acquisition. By applying an untargeted metabolomics approach, we could reproducibly measure over 800 metabolite features. RESULTS: We detected underlying molecular perturbations across several metabolite classes that precede autism. In particular, the cyclic dipeptide cyclo-leucine-proline (FDR-adjusted p = 0.003) and the carnitine-related 5-aminovaleric acid betaine (5-AVAB) (FDR-adjusted p = 0.03), were associated with an increased probability for autism, independently of known prenatal and genetic risk factors. Analysis of genetic and dietary data in adults revealed that 5-AVAB was associated with increased habitual dietary intake of dairy (FDR-adjusted p < 0.05) and with variants near SLC22A4 and SLC22A5 (p < 5.0e - 8), coding for a transmembrane carnitine transporter protein involved in controlling intracellular carnitine levels. CONCLUSIONS: Cyclo-leucine-proline and 5-AVAB are associated with future diagnosis of autism in Danish neonates, both representing novel early biomarkers for autism. 5-AVAB is potentially modifiable and may influence carnitine homeostasis. CI - (c) 2024. The Author(s). FAU - Ottosson, Filip AU - Ottosson F AUID- ORCID: 0000-0002-8312-3545 AD - Section for Clinical Mass Spectrometry, Danish Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark. faot@ssi.dk. AD - The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark. faot@ssi.dk. FAU - Russo, Francesco AU - Russo F AD - Section for Clinical Mass Spectrometry, Danish Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark. AD - The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark. FAU - Abrahamsson, Anna AU - Abrahamsson A AD - Section for Clinical Mass Spectrometry, Danish Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark. FAU - MacSween, Nadia AU - MacSween N AD - Section for Clinical Mass Spectrometry, Danish Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark. FAU - Courraud, Julie AU - Courraud J AD - Section for Clinical Mass Spectrometry, Danish Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark. AD - The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark. AD - Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, 15771, Panepistimiopolis, ZografouAthens, Greece. AD - Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Alexandra Hospital, 11528, Athens, Greece. FAU - Skogstrand, Kristin AU - Skogstrand K AD - Section for Clinical Mass Spectrometry, Danish Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark. AD - The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark. FAU - Melander, Olle AU - Melander O AD - Department of Clinical Sciences, Lund University, Malmo, Sweden. FAU - Ericson, Ulrika AU - Ericson U AD - Department of Clinical Sciences, Lund University, Malmo, Sweden. FAU - Orho-Melander, Marju AU - Orho-Melander M AD - Department of Clinical Sciences, Lund University, Malmo, Sweden. FAU - Cohen, Arieh S AU - Cohen AS AD - Section for Clinical Mass Spectrometry, Danish Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark. AD - The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark. AD - Testcenter Denmark, Statens Serum Institut, Copenhagen, Denmark. FAU - Grove, Jakob AU - Grove J AD - The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark. AD - Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark. AD - Bioinformatics Research Center, Aarhus University, Aarhus, Denmark. AD - Center for Genomics and Personalized Medicine, Aarhus, Denmark. FAU - Mortensen, Preben Bo AU - Mortensen PB AD - The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark. AD - NCRR - National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark. AD - CIRRAU - Centre for Integrated Registerbased Research at Aarhus University, Aarhus, Denmark. FAU - Hougaard, David M AU - Hougaard DM AD - Section for Clinical Mass Spectrometry, Danish Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark. AD - The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark. FAU - Ernst, Madeleine AU - Ernst M AUID- ORCID: 0000-0001-9530-3837 AD - Section for Clinical Mass Spectrometry, Danish Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark. maet@ssi.dk. AD - The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark. maet@ssi.dk. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240719 PL - England TA - BMC Med JT - BMC medicine JID - 101190723 RN - 3SCV180C9W (Betaine) SB - IM MH - Humans MH - Denmark/epidemiology MH - Female MH - *Metabolomics/methods MH - Male MH - *Autistic Disorder/epidemiology/blood/genetics MH - Infant, Newborn MH - Cohort Studies MH - Adult MH - Metabolome MH - Betaine/blood PMC - PMC11264881 OTO - NOTNLM OT - 5-Aminovaleric acid betaine OT - Autism OT - Cyclo-leucine-proline OT - Dried blood spot OT - Metabolome OT - Metabolomics OT - Neonatal COIS- The authors declare that they have no competing interests. EDAT- 2024/07/19 00:41 MHDA- 2024/07/19 06:42 PMCR- 2024/07/19 CRDT- 2024/07/18 23:41 PHST- 2024/01/23 00:00 [received] PHST- 2024/07/02 00:00 [accepted] PHST- 2024/07/19 06:42 [medline] PHST- 2024/07/19 00:41 [pubmed] PHST- 2024/07/18 23:41 [entrez] PHST- 2024/07/19 00:00 [pmc-release] AID - 10.1186/s12916-024-03516-7 [pii] AID - 3516 [pii] AID - 10.1186/s12916-024-03516-7 [doi] PST - epublish SO - BMC Med. 2024 Jul 19;22(1):302. doi: 10.1186/s12916-024-03516-7. PMID- 39025639 OWN - NLM STAT- MEDLINE DCOM- 20240909 LR - 20260408 IS - 1936-959X (Electronic) IS - 0195-6108 (Print) IS - 0195-6108 (Linking) VI - 45 IP - 9 DP - 2024 Sep 9 TI - Development of Myelin Growth Charts of the White Matter Using T1 Relaxometry. PG - 1335-1345 LID - 10.3174/ajnr.A8306 [doi] AB - BACKGROUND AND PURPOSE: Myelin maturation occurs in late fetal life to early adulthood, with the most rapid changes observed in the first few years of infancy. To quantify the degree of myelination, a specific MR imaging sequence is required to measure the changes in tissue proton relaxivity (R1). R1 positively correlates with the degree of myelination maturation at a given age. Similar to head circumference charts, these data can be used to develop normal growth charts for specific white matter tracts to detect pathologies involving abnormal myelination. MATERIALS AND METHODS: This is a cross-sectional study using normal clinical pediatric brain MR images with the MP2RAGE sequence to generate T1 maps. The T1 maps were segmented to 75 brain regions from a brain atlas (white matter and gyri). Statistical modeling for all subjects across regions and the age range was computed, and estimates of population-level percentile ranking were computed to describe the effective myelination rate as a function of age. Test-retest analysis was performed to assess reproducibility. Logistic trendline and regression were performed for selected white matter regions and plotted for growth charts. RESULTS: After exclusion for abnormal MR imaging or diseases affecting myelination from the electronic medical record, 103 subject MR images were included, ranging from birth to 17 years of age. Test-retest analysis resulted in a high correlation for white matter (r = 0.88) and gyri (r = 0.95). All white matter regions from the atlas had significant P values for logistic regression with R (2) values ranging from 0.41 to 0.99. CONCLUSIONS: These data can serve as a myelination growth chart to permit patient comparisons with normal levels with respect to age and brain regions, thus improving detection of developmental disorders affecting myelin. CI - (c) 2024 by American Journal of Neuroradiology. FAU - Ho, Chang Y AU - Ho CY AUID- ORCID: 0000-0002-2358-1851 AD - From the Department of Radiology and Imaging Sciences (C.Y.H., P.R.T.), Indiana University School of Medicine, Indianapolis, Indiana cyho@iu.edu. FAU - Persohn, Scott AU - Persohn S AUID- ORCID: 0000-0001-5047-8238 AD - Department of Medicine (S.P., M.S., P.R.T.), Indiana University School of Medicine, Indianapolis, Indiana. FAU - Sankar, Meghana AU - Sankar M AD - Department of Medicine (S.P., M.S., P.R.T.), Indiana University School of Medicine, Indianapolis, Indiana. FAU - Territo, Paul R AU - Territo PR AUID- ORCID: 0000-0003-0460-332X AD - From the Department of Radiology and Imaging Sciences (C.Y.H., P.R.T.), Indiana University School of Medicine, Indianapolis, Indiana. AD - Department of Medicine (S.P., M.S., P.R.T.), Indiana University School of Medicine, Indianapolis, Indiana. AD - Stark Neuroscience Research Institute (P.R.T.), Indiana University School of Medicine, Indianapolis, Indiana. LA - eng PT - Journal Article DEP - 20240909 PL - United States TA - AJNR Am J Neuroradiol JT - AJNR. American journal of neuroradiology JID - 8003708 SB - IM MH - Humans MH - *White Matter/diagnostic imaging/growth & development MH - *Myelin Sheath MH - Child MH - Adolescent MH - Female MH - Child, Preschool MH - Infant MH - Male MH - *Magnetic Resonance Imaging/methods MH - Cross-Sectional Studies MH - Infant, Newborn MH - Growth Charts MH - Reproducibility of Results MH - Reference Values PMC - PMC11392380 EDAT- 2024/07/19 00:41 MHDA- 2024/09/10 00:43 PMCR- 2025/09/01 CRDT- 2024/07/18 21:03 PHST- 2023/11/29 00:00 [received] PHST- 2024/04/02 00:00 [accepted] PHST- 2024/09/10 00:43 [medline] PHST- 2024/07/19 00:41 [pubmed] PHST- 2024/07/18 21:03 [entrez] PHST- 2025/09/01 00:00 [pmc-release] AID - ajnr.A8306 [pii] AID - 23-01032 [pii] AID - 10.3174/ajnr.A8306 [doi] PST - epublish SO - AJNR Am J Neuroradiol. 2024 Sep 9;45(9):1335-1345. doi: 10.3174/ajnr.A8306. PMID- 39025003 OWN - NLM STAT- MEDLINE DCOM- 20240727 LR - 20260209 IS - 1873-6327 (Electronic) IS - 0306-4603 (Print) IS - 0306-4603 (Linking) VI - 157 DP - 2024 Oct TI - An adaptation and exploratory factor analysis of the smoking-related weight and eating episodes test (SWEET) for electronic cigarette users. PG - 108102 LID - S0306-4603(24)00151-5 [pii] LID - 10.1016/j.addbeh.2024.108102 [doi] AB - INTRODUCTION: Smoking for weight control is a well-documented behavior. There is emerging evidence to suggest electronic cigarettes (e-cigarettes) may be used for similar motivations yet measure development for the use of e-cigarettes for weight control has received less attention. The objective of the current study was to adapt and explore the psychometric properties of The Smoking-Related Weight and Eating Episodes Test (SWEET) for e-cigarette users. METHODS: Young adult (N=1875) current cigarette, e-cigarette, and dual users completed the original SWEET (SWEET-C) and/or adapted SWEET for e-cigarette use (SWEET-EC) based on current tobacco product use. Demographics, associated e-cigarette characteristics, nicotine dependence, outcome expectancies, and eating disorder behaviors were also assessed. Participants were recruited online and measures were completed via self-report. RESULTS: Four exploratory factor analyses using principal components extraction and direct oblimin rotation methods were run to explore the SWEET-C and SWEET-EC. A one-factor solution explaining 66 % of the variance was retained for the SWEET-C, and a one-factor solution explaining 73 % of the variance was retained for the SWEET-EC. Both measures exhibited excellent internal consistency. Higher SWEET-EC scores were observed among dual users, and were associated with daily e-cigarette use, JUUL use, self-reported vaping for weight control, older age, higher body mass index, and problematic eating behaviors. CONCLUSION: Our findings support the adaptation of the SWEET-EC to measure e-cigarette use for weight control. The SWEET-EC will help to better understand how individuals use e-cigarettes to curb eating behavior and for weight control. CI - Copyright (c) 2024 Elsevier Ltd. All rights reserved. FAU - Smith, Caitlin E AU - Smith CE AD - Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA. Electronic address: caitlin.smith@yale.edu. FAU - Mason, Tyler B AU - Mason TB AD - Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA. FAU - Wright, Naim AU - Wright N AD - Duke University, Durham, NC, USA. FAU - Ruttledge, Emily AU - Ruttledge E AD - Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA. FAU - Norris, Jordan E AU - Norris JE AD - Department of Psychology, University of Oklahoma, Norman, OK, USA. FAU - Monterosso, John R AU - Monterosso JR AD - Department of Psychology, University of Southern California, Los Angeles, CA, USA. FAU - Tackett, Alayna P AU - Tackett AP AD - Department of Internal Medicine, Center for Tobacco Research, The Ohio State University, Columbus, OH, USA. LA - eng GR - K01 HL148907/HL/NHLBI NIH HHS/United States GR - UL1 TR001863/TR/NCATS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20240714 PL - England TA - Addict Behav JT - Addictive behaviors JID - 7603486 SB - IM MH - Humans MH - Male MH - Female MH - *Vaping/psychology MH - Young Adult MH - Adult MH - *Electronic Nicotine Delivery Systems MH - *Psychometrics MH - Factor Analysis, Statistical MH - Adolescent MH - Feeding Behavior/psychology MH - Feeding and Eating Disorders/psychology MH - Tobacco Use Disorder/psychology PMC - PMC11332417 MID - NIHMS2012160 OTO - NOTNLM OT - Cigarette use OT - E-cigarette use OT - Scale development OT - Tobacco use for eating/weight control OT - Young adults COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/07/19 00:42 MHDA- 2024/07/28 14:48 PMCR- 2025/10/01 CRDT- 2024/07/18 18:26 PHST- 2024/03/29 00:00 [received] PHST- 2024/06/30 00:00 [revised] PHST- 2024/07/09 00:00 [accepted] PHST- 2024/07/28 14:48 [medline] PHST- 2024/07/19 00:42 [pubmed] PHST- 2024/07/18 18:26 [entrez] PHST- 2025/10/01 00:00 [pmc-release] AID - S0306-4603(24)00151-5 [pii] AID - 10.1016/j.addbeh.2024.108102 [doi] PST - ppublish SO - Addict Behav. 2024 Oct;157:108102. doi: 10.1016/j.addbeh.2024.108102. Epub 2024 Jul 14. PMID- 39024324 OWN - NLM STAT- MEDLINE DCOM- 20240718 LR - 20260915 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 7 DP - 2024 TI - Allometric multi-scaling of weight-for-height relation in children and adolescents: Revisiting the theoretical basis of body mass index of thinness and obesity assessment. PG - e0307238 LID - 10.1371/journal.pone.0307238 [doi] LID - e0307238 AB - The body mass index (BMI), defined as weight in kilograms divided by height in meters squared, has been widely used to assess thinness and obesity in all age groups, including children and adolescents. However, the validity and utility of BMI as a reliable measure of nutritional health have been questioned. This study discusses the mathematical conditions that support the validity of BMI based on population statistics. Here, we propose a condition defined as allometric uni-scaling to ensure the validity of BMI as an objective height-adjusted measure. Any given centile curve, including the median curve, in a weight-for-height distribution should be approximated using power-law functions with the same scaling exponent. In contrast, when the scaling exponent varies depending on the position of the centile curve, it is called allometric multi-scaling. By introducing a method for testing these scaling properties using quantile regression, we analyzed a large-scale Japanese database that included 7,863,520 children aged 5-17 years. We demonstrated the remarkable multi-scaling properties at ages 5-13 years for males and 5-11 years for females, and the convergence to uni-scaling with a scaling exponent close to 2 as they approached 17 years of age for both sexes. We confirmed that conventional BMI is appropriate as an objective height-adjusted mass measure at least 17 years of age, close to adulthood, for both males and females. However, the validity of BMI could not be confirmed in younger age groups. Our findings indicate that the growth of children's weight-for-height relation is much more complex than previously assumed. Therefore, a single BMI-type formula cannot be used to assess thinness and obesity in children and adolescents. CI - Copyright: (c) 2024 Ogata et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Ogata, Hitomi AU - Ogata H AUID- ORCID: 0000-0002-7151-4733 AD - Graduate School of Humanities and Social Sciences, Hiroshima University, Hiroshima, Japan. FAU - Isoyama, Yosuke AU - Isoyama Y AD - Graduate School of Engineering Science, Osaka University, Osaka, Japan. FAU - Nose-Ogura, Sayaka AU - Nose-Ogura S AD - JAPAN High Performance Sport Center, Department of Sports Medicine and Research, Japan Institute Sports Sciences, Tokyo, Japan. AD - Department of Obstetrics and Gynecology, University of Tokyo Hospital, Tokyo, Japan. FAU - Nagai, Narumi AU - Nagai N AD - School of Human Science and Environment, University of Hyogo, Himeji, Japan. FAU - Kayaba, Momoko AU - Kayaba M AD - Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. FAU - Kruse, Joao Gabriel Segato AU - Kruse JGS AD - Graduate School of Engineering Science, Osaka University, Osaka, Japan. FAU - Seleznov, Ivan AU - Seleznov I AD - Graduate School of Engineering Science, Osaka University, Osaka, Japan. FAU - Kaneko, Miki AU - Kaneko M AD - Graduate School of Engineering Science, Osaka University, Osaka, Japan. FAU - Shigematsu, Taiki AU - Shigematsu T AD - Graduate School of Engineering Science, Osaka University, Osaka, Japan. FAU - Kiyono, Ken AU - Kiyono K AUID- ORCID: 0000-0001-5433-7002 AD - Graduate School of Engineering Science, Osaka University, Osaka, Japan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240718 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Body Mass Index MH - Child MH - Adolescent MH - Female MH - Male MH - *Thinness MH - *Body Weight MH - *Body Height MH - Child, Preschool MH - *Obesity PMC - PMC11257299 COIS- The authors have declared that no competing interests exist. EDAT- 2024/07/18 18:42 MHDA- 2024/07/18 18:43 PMCR- 2024/07/18 CRDT- 2024/07/18 13:53 PHST- 2023/09/17 00:00 [received] PHST- 2024/07/01 00:00 [accepted] PHST- 2024/07/18 18:43 [medline] PHST- 2024/07/18 18:42 [pubmed] PHST- 2024/07/18 13:53 [entrez] PHST- 2024/07/18 00:00 [pmc-release] AID - PONE-D-23-30203 [pii] AID - 10.1371/journal.pone.0307238 [doi] PST - epublish SO - PLoS One. 2024 Jul 18;19(7):e0307238. doi: 10.1371/journal.pone.0307238. eCollection 2024. PMID- 39023923 OWN - NLM STAT- MEDLINE DCOM- 20240923 LR - 20260416 IS - 2769-755X (Electronic) IS - 2769-7541 (Print) IS - 2769-7541 (Linking) VI - 133 IP - 7 DP - 2024 Oct TI - Identifying factors impacting missingness within smartphone-based research: Implications for intensive longitudinal studies of adolescent suicidal thoughts and behaviors. PG - 577-597 LID - 10.1037/abn0000930 [doi] AB - Intensive longitudinal research-including experience sampling and smartphone sensor monitoring-has potential for identifying proximal risk factors for psychopathology, including suicidal thoughts and behaviors (STB). Yet, missing data can complicate analysis and interpretation. This study aimed to address whether clinical and study design factors are associated with missing data and whether missingness predicts changes in symptom severity or STB. Adolescents ages 13- to 18 years old (N = 179) reporting depressive, anxiety, and/or substance use disorders were enrolled; 65% reported current suicidal ideation and 29% indicated a past-year attempt. Passively acquired smartphone sensor data (e.g., global positioning system, accelerometer, and keyboard inputs), daily mood surveys, and weekly suicidal ideation surveys were collected during the 6-month study period using the effortless assessment research system smartphone app. First, acquisition of passive smartphone sensor data (with data on approximately 80% of days across the whole sample) was strongly associated with survey data acquisition on the same day ( approximately 44% of days). Second, STB and psychiatric symptoms were largely not associated with missing data. Rather, temporal features (e.g., length of time in study, weekends, and summer) explained more missingness of survey and passive smartphone sensor data. Last, within-participant changes in missing data over time neither followed nor predicted subsequent change in suicidal ideation and psychiatric symptoms. Findings indicate that considering technical and study design factors impacting missingness is critical and highlight several factors that should be addressed to maximize the validity of clinical interpretations in intensive longitudinal research. (PsycInfo Database Record (c) 2024 APA, all rights reserved). FAU - Bloom, Paul A AU - Bloom PA AUID- ORCID: 0000-0003-3970-5721 AD - Department of Psychiatry, New York State Psychiatric Institute, Columbia University Irving Medical Center. FAU - Lan, Ranqing AU - Lan R AD - Department of Psychiatry, New York State Psychiatric Institute, Columbia University Irving Medical Center. FAU - Galfalvy, Hanga AU - Galfalvy H AUID- ORCID: 0000-0001-7156-6106 AD - Department of Psychiatry, New York State Psychiatric Institute, Columbia University Irving Medical Center. FAU - Liu, Ying AU - Liu Y AD - Department of Psychiatry, New York State Psychiatric Institute, Columbia University Irving Medical Center. FAU - Bitran, Alma AU - Bitran A AD - Department of Psychiatry, New York State Psychiatric Institute, Columbia University Irving Medical Center. FAU - Joyce, Karla AU - Joyce K AD - Department of Psychiatry, University of Pittsburgh Medical Center. FAU - Durham, Katherine AU - Durham K AD - Department of Psychiatry, New York State Psychiatric Institute, Columbia University Irving Medical Center. FAU - Porta, Giovanna AU - Porta G AD - Western Psychiatric Hospital, University of Pittsburgh Medical Center. FAU - Kirshenbaum, Jaclyn S AU - Kirshenbaum JS AUID- ORCID: 0000-0001-8685-5840 AD - Department of Psychiatry, New York State Psychiatric Institute, Columbia University Irving Medical Center. FAU - Kamath, Rahil AU - Kamath R AD - Department of Psychiatry, New York State Psychiatric Institute, Columbia University Irving Medical Center. FAU - Tse, Trinity C AU - Tse TC AD - Department of Psychiatry, New York State Psychiatric Institute, Columbia University Irving Medical Center. FAU - Chernick, Lauren AU - Chernick L AD - Department of Emergency Medicine, Columbia University Medical Center. FAU - Kahn, Lauren E AU - Kahn LE AD - Ksana Health. FAU - Crowley, Ryann AU - Crowley R AD - Ksana Health. FAU - Trivedi, Esha AU - Trivedi E AUID- ORCID: 0009-0003-5658-5546 AD - Department of Psychiatry, New York State Psychiatric Institute, Columbia University Irving Medical Center. FAU - Brent, David AU - Brent D AUID- ORCID: 0000-0002-5756-2157 AD - Department of Psychiatry, University of Pittsburgh Medical Center. FAU - Allen, Nicholas B AU - Allen NB AUID- ORCID: 0000-0002-1086-6639 AD - Department of Psychology, University of Oregon. FAU - Pagliaccio, David AU - Pagliaccio D AUID- ORCID: 0000-0002-1214-1965 AD - Department of Psychiatry, New York State Psychiatric Institute, Columbia University Irving Medical Center. FAU - Auerbach, Randy P AU - Auerbach RP AUID- ORCID: 0000-0003-2319-4744 AD - Department of Psychiatry, New York State Psychiatric Institute, Columbia University Irving Medical Center. LA - eng GR - Beckwith Foundation/ GR - Morgan Stanley Foundation/ GR - Tommy Fuss Fund/ GR - Once Upon a Time Foundation/ GR - U01 MH116923/MH/NIMH NIH HHS/United States GR - American Foundation for Suicide Prevention/ GR - T32 MH016434/MH/NIMH NIH HHS/United States PT - Journal Article DEP - 20240718 PL - United States TA - J Psychopathol Clin Sci JT - Journal of psychopathology and clinical science JID - 9918351179206676 SB - IM MH - Humans MH - Adolescent MH - *Suicidal Ideation MH - *Smartphone MH - Male MH - Longitudinal Studies MH - Female MH - Adolescent Behavior/psychology MH - Research Design MH - Substance-Related Disorders/epidemiology/psychology/diagnosis MH - Suicide, Attempted/psychology/statistics & numerical data MH - Ecological Momentary Assessment PMC - PMC12083753 MID - NIHMS2055834 COIS- Competing Interests During the past 3 years, Dr. Auerbach has received funding from the NIMH, Tommy Fuss Fund, and Morgan Stanley Foundation. RPA is an unpaid scientific advisor for Ksana Health and paid scientific advisor for Get Sonar, Inc. NBA, RC, and LK all receive salary from, and have an equity interest in, Ksana Health Inc. who hold the license for commercial sales of the EARS software described in this application. Dr. Brent receives research support from NIMH, AFSP, the Once Upon a Time Foundation, and the Beckwith Foundation, receives royalties from Guilford Press, from the electronic self-rated version of the C-SSRS from eRT, Inc., and from performing duties as an UptoDate Inc. Psychiatry Section Editor, and receives consulting fees from Healthwise. Dr. Brent has invention disclosures and IP rights over the applications, Computerized Adaptive Screen for Suicidal Youth (CASSY), BRITE, and Screening Wizard. EDAT- 2024/07/18 12:44 MHDA- 2024/09/23 12:44 PMCR- 2025/10/01 CRDT- 2024/07/18 11:42 PHST- 2024/09/23 12:44 [medline] PHST- 2024/07/18 12:44 [pubmed] PHST- 2024/07/18 11:42 [entrez] PHST- 2025/10/01 00:00 [pmc-release] AID - 2025-05014-001 [pii] AID - 10.1037/abn0000930 [doi] PST - ppublish SO - J Psychopathol Clin Sci. 2024 Oct;133(7):577-597. doi: 10.1037/abn0000930. Epub 2024 Jul 18. PMID- 39020357 OWN - NLM STAT- MEDLINE DCOM- 20240718 LR - 20250129 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 Jul 17 TI - Prevalence and perception of pre-morbid lifestyle-related risk factors among covid-19 survivors in Lagos state and Abuja capital city of Nigeria. PG - 1918 LID - 10.1186/s12889-024-19502-w [doi] LID - 1918 AB - INTRODUCTION: This study investigated the prevalence and perception of premorbid lifestyle-related risk factors among Covid-19 Survivors in Abuja and Lagos, Nigeria. METHODOLOGY: A cross-sectional descriptive survey design was used to collect data from 522 consenting adult Covid-19 survivors in Abuja (274) and Lagos (248), Nigeria, using a self-developed, close-ended and validated questionnaire called the Lifestyle-related Factors in Covid-19 Questionnaire (LFC-19 Questionnaire) through a multistage sampling technique. Descriptive and inferential statistical analysis was done using the Statistical Package for Social Science (SPSS) with P value set at 0.75 and coefficient of variation <9.0%). Younger players (i.e., U14 and U16) displayed lower tau values (effect size: moderate to large; p < 0.02) compared with their older peers (i.e., U18 and Seniors), regardless of their playing position. Moreover, tau was associated with sprint performance metrics at varying levels of correlations (Rho: small to almost perfect; p < 0.001). In conclusion, younger players exhibited lower tau values than their older counterparts, irrespective of their playing positions. The model employed in this study demonstrated its accuracy in assessing several key sprint performance metrics, offering insights that can enhance sprint training programs for rugby players, which can be based on the associations observed among these different variables. CI - Copyright (c) 2024 National Strength and Conditioning Association. FAU - Zabaloy, Santiago AU - Zabaloy S AUID- ORCID: 0000-0002-5408-5682 AD - Faculty of Physical Activity and Sports, University of Flores, Buenos Aires, Argentina. AD - Carnegie School of Sports, Leeds Beckett University, Leeds, United Kingdom. FAU - Freitas, Tomas T AU - Freitas TT AD - UCAM Research Center for High Performance Sport, UCAM Universidad Catolica de Murcia, Murcia, Spain. AD - Nucleus of High Performance in Sport (NAR), Sao Paulo, Brazil. AD - Facultad de Deporte, UCAM Universidad Catolica de Murcia, Murcia, Spain. FAU - Alcaraz, Pedro E AU - Alcaraz PE AD - UCAM Research Center for High Performance Sport, UCAM Universidad Catolica de Murcia, Murcia, Spain. FAU - Galvez-Gonzalez, Javier AU - Galvez-Gonzalez J AD - Faculty of Sports Sciences, Pablo de Olavide University, Seville, Spain. FAU - Pereira, Lucas A AU - Pereira LA AD - Nucleus of High Performance in Sport (NAR), Sao Paulo, Brazil. AD - Department of Human Movement Sciences, Federal University of Sao Paulo, Sao Paulo, Brazil. FAU - Comyns, Tom AU - Comyns T AD - Department of Physical Education and Sport Sciences, University of Limerick, Limerick, Ireland. FAU - Loturco, Irineu AU - Loturco I AD - Nucleus of High Performance in Sport (NAR), Sao Paulo, Brazil. AD - Department of Human Movement Sciences, Federal University of Sao Paulo, Sao Paulo, Brazil. AD - University of South Wales, Pontypridd, Wales, United Kingdom; and. FAU - Healy, Robin AU - Healy R AD - Department of Sport and Health Sciences, Athlone Institute of Technology, Ireland. LA - eng PT - Journal Article DEP - 20240716 PL - United States TA - J Strength Cond Res JT - Journal of strength and conditioning research JID - 9415084 SB - IM MH - Humans MH - Male MH - *Football/physiology MH - *Athletic Performance/physiology MH - *Acceleration MH - *Running/physiology MH - Age Factors MH - Adolescent MH - Child MH - Reproducibility of Results MH - Young Adult EDAT- 2024/07/17 12:44 MHDA- 2025/04/01 18:24 CRDT- 2024/07/17 07:33 PHST- 2025/04/01 18:24 [medline] PHST- 2024/07/17 12:44 [pubmed] PHST- 2024/07/17 07:33 [entrez] AID - 00124278-202410000-00011 [pii] AID - 10.1519/JSC.0000000000004861 [doi] PST - ppublish SO - J Strength Cond Res. 2024 Oct 1;38(10):1778-1785. doi: 10.1519/JSC.0000000000004861. Epub 2024 Jul 16. PMID- 39015337 OWN - NLM STAT- MEDLINE DCOM- 20240717 LR - 20260923 IS - 2235-2988 (Electronic) IS - 2235-2988 (Linking) VI - 14 DP - 2024 TI - Investigations of microbiota composition and neuroactive pathways in association with symptoms of stress and depression in a cohort of healthy women. PG - 1324794 LID - 10.3389/fcimb.2024.1324794 [doi] LID - 1324794 AB - BACKGROUND: Despite mounting evidence of gut-brain involvement in psychiatric conditions, functional data remain limited, and analyses of other microbial niches, such as the vaginal microbiota, are lacking in relation to mental health. This aim of this study was to investigate if the connections between the gut microbiome and mental health observed in populations with a clinical diagnosis of mental illness extend to healthy women experiencing stress and depressive symptoms. Additionally, this study examined the functional pathways of the gut microbiota according to the levels of psychological symptoms. Furthermore, the study aimed to explore potential correlations between the vaginal microbiome and mental health parameters in young women without psychiatric diagnoses. METHODS: In this cross-sectional study, 160 healthy Danish women (aged 18-40 years) filled out questionnaires with validated scales measuring symptoms of stress and depression and frequency of dietary intake. Fecal and vaginal microbiota samples were collected at the beginning of the menstrual cycle and vaginal samples were also collected at cycle day 8-12 and 18-22. Shotgun metagenomic profiling of the gut and vaginal microbiome was performed. The Kyoto Encyclopedia of Genes and Genomes (KEGG) was used for functional profiling and 56 Gut Brain Modules were analyzed in the fecal samples. RESULTS: The relative abundance in the gut of the genera Escherichia, Parabacteroides, and Shigella was higher in women with elevated depressive symptoms. Women with high perceived stress showed a tendency of increased abundance of Escherichia, Shigella, and Blautia. Amongst others, the potentially pathogenic genera, Escherichia and Shigella correlate with alterations in the neuroactive pathways such as the glutamatergic, GABAeric, dopaminergic, and Kynurenine pathways. Vaginosis symptoms were more prevalent in women reporting high levels of stress and depressive symptoms. CONCLUSIONS: The findings of this study support the concept of a microbiota-associated effect on the neuroactive pathways even in healthy young women. This suggest, that targeting the gut microbiome could be a promising approach for future psychiatric interventions. CI - Copyright (c) 2024 Bashir, Hugerth, Krog, Prast-Nielsen, Edfeldt, Boulund, Schacht, Tetens, Engstrand, Schuppe-Koistinen, Fransson and Nielsen. FAU - Bashir, Zahra AU - Bashir Z AD - Department of Obstetrics and Gynecology, Slagelse Hospital, Slagelse, Denmark. AD - The Recurrent Pregnancy Loss Unit, Dept. of Fertility, The Capital Region, Copenhagen University Hospitals, Rigshospitalet, Copenhagen, Denmark. AD - Dept. of Obstetrics and Gynecology, Hvidovre Hospital, Hvidovre, Denmark. FAU - Hugerth, Luisa W AU - Hugerth LW AD - Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. AD - Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden. FAU - Krog, Maria Christine AU - Krog MC AD - The Recurrent Pregnancy Loss Unit, Dept. of Fertility, The Capital Region, Copenhagen University Hospitals, Rigshospitalet, Copenhagen, Denmark. AD - Dept. of Obstetrics and Gynecology, Hvidovre Hospital, Hvidovre, Denmark. AD - Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. FAU - Prast-Nielsen, Stefanie AU - Prast-Nielsen S AD - Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. FAU - Edfeldt, Gabriella AU - Edfeldt G AD - Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. FAU - Boulund, Fredrik AU - Boulund F AD - Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. AD - Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden. FAU - Schacht, Simon Ronnow AU - Schacht SR AD - Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark. FAU - Tetens, Inge AU - Tetens I AD - Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark. FAU - Engstrand, Lars AU - Engstrand L AD - Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. AD - Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden. FAU - Schuppe-Koistinen, Ina AU - Schuppe-Koistinen I AD - Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. AD - Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden. FAU - Fransson, Emma AU - Fransson E AD - Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. FAU - Nielsen, Henriette Svarre AU - Nielsen HS AD - The Recurrent Pregnancy Loss Unit, Dept. of Fertility, The Capital Region, Copenhagen University Hospitals, Rigshospitalet, Copenhagen, Denmark. AD - Dept. of Obstetrics and Gynecology, Hvidovre Hospital, Hvidovre, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. AD - Department of Obstetrics and Gynecology, Hvidovre Hospital, Copenhagen, Denmark. LA - eng PT - Journal Article DEP - 20240702 PL - Switzerland TA - Front Cell Infect Microbiol JT - Frontiers in cellular and infection microbiology JID - 101585359 SB - IM MH - Humans MH - Female MH - Adult MH - Young Adult MH - Cross-Sectional Studies MH - *Gastrointestinal Microbiome MH - Adolescent MH - *Depression/microbiology MH - *Vagina/microbiology MH - *Feces/microbiology MH - *Stress, Psychological/microbiology MH - Microbiota MH - Denmark MH - Healthy Volunteers MH - Brain-Gut Axis/physiology MH - Surveys and Questionnaires MH - Metagenomics/methods MH - Bacteria/classification/genetics/isolation & purification PMC - PMC11249552 OTO - NOTNLM OT - (microbiota-)gut-brain axis OT - depressive symptoms OT - diet OT - microbiome OT - perceived stress OT - proteobacteria OT - shotgun sequencing OT - tryptophan COIS- An unrestricted research grant from Ferring Pharmaceuticals enabled the clinical infrastructure, and sampling as well as the analyses at the Centre for Translational Microbiome Research. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication. EDAT- 2024/07/17 06:43 MHDA- 2024/07/17 06:44 PMCR- 2024/01/01 CRDT- 2024/07/17 04:17 PHST- 2023/10/23 00:00 [received] PHST- 2024/06/07 00:00 [accepted] PHST- 2024/07/17 06:44 [medline] PHST- 2024/07/17 06:43 [pubmed] PHST- 2024/07/17 04:17 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - 10.3389/fcimb.2024.1324794 [doi] PST - epublish SO - Front Cell Infect Microbiol. 2024 Jul 2;14:1324794. doi: 10.3389/fcimb.2024.1324794. eCollection 2024. PMID- 39014347 OWN - NLM STAT- MEDLINE DCOM- 20240717 LR - 20250129 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 Jul 16 TI - Exploring food consumption patterns in the province of Kenitra, Northwest of Morocco. PG - 1899 LID - 10.1186/s12889-024-19335-7 [doi] LID - 1899 AB - BACKGROUND: Morocco is currently undergoing rapid changes in diets and lifestyles, influenced by globalization and urbanization, leading to a shift away from the Mediterranean diet (MedDiet) toward Western diets. OBJECTIVE: Describe and explore the food consumption patterns of the population of Kenitra province and their adherence to the MedDiet using a validated survey. METHOD: The current cross-sectional study involved 442 respondents from Kenitra province, comprising individuals aged 18 and above. The survey included a combination of closed and open-ended questions regarding food consumption patterns and socio-demographic characteristics. Adherence to the MedDiet was assessed using the Panagiotakos method to calculate the MedDiet score (MDS). Additionally, each participant's adherence to the MedDiet was evaluated using a method based on Martinez-Gonzalez's approach. RESULTS: The results indicate that 31% of the participants eat vegetables, 28% eat fruits, and 19% eat wholegrain bread daily. Furthermore, 58% regularly use olive oil in their cooking. Eating out of home (OOH) was high, with popular places being restaurants and cafes (70%), fast food outlets (20%), and workplace canteens (7%). Overall, participants showed moderate adherence to the MedDiet, with a mean MDS of 36.3 +/- 19.7. CONCLUSIONS: Promoting healthy eating habits is crucial in Kenitra. With moderate consumption of nutrient-dense foods and the popularity of the MedDiet, targeted interventions and educational initiatives can promote healthy dietary behaviors, improving overall public health. CI - (c) 2024. The Author(s). FAU - Hindi, Zakia AU - Hindi Z AD - Biology and Health Laboratory, Department of Life Sciences, Faculty of Sciences, University Ibn Tofail, B.P. 133, Kenitra, 14000, Morocco. FAU - Belfakira, Chaimaa AU - Belfakira C AD - Biology and Health Laboratory, Department of Life Sciences, Faculty of Sciences, University Ibn Tofail, B.P. 133, Kenitra, 14000, Morocco. FAU - Lafram, Amina AU - Lafram A AD - Biology and Health Laboratory, Department of Life Sciences, Faculty of Sciences, University Ibn Tofail, B.P. 133, Kenitra, 14000, Morocco. FAU - Bikri, Samir AU - Bikri S AD - Biology and Health Laboratory, Department of Life Sciences, Faculty of Sciences, University Ibn Tofail, B.P. 133, Kenitra, 14000, Morocco. FAU - Benayad, Asmaa AU - Benayad A AD - Biology and Health Laboratory, Department of Life Sciences, Faculty of Sciences, University Ibn Tofail, B.P. 133, Kenitra, 14000, Morocco. FAU - El Bilali, Hamid AU - El Bilali H AD - International Centre for Advanced Mediterranean Agronomic Studies (CIHEAM-Bari), Valenzano (Bari), 70010, Italy. FAU - Bugel, Susanne Gjedsted AU - Bugel SG AD - Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark. FAU - Srednicka-Tober, Dominika AU - Srednicka-Tober D AD - Department of Functional and Organic Food, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences, Nowoursynowska 159c, Warsaw, 02-776, Poland. FAU - Pugliese, Patrizia AU - Pugliese P AD - International Centre for Advanced Mediterranean Agronomic Studies (CIHEAM-Bari), Valenzano (Bari), 70010, Italy. FAU - Strassner, Carola AU - Strassner C AD - Department of Food - Nutrition - Facilities, FH Munster University of Applied Sciences, Munster, Germany. FAU - Rossi, Laura AU - Rossi L AD - Council for Agricultural Research and Economics - Research Centre for Food and Nutrition, CREA - Food and Nutrition), Rome, Italy. FAU - Stefanovic, Lilliana AU - Stefanovic L AD - Section of Organic Food Quality, Faculty of Organic Agricultural Sciences, University of Kassel, Kassel, Germany. FAU - Aboussaleh, Youssef AU - Aboussaleh Y AD - Biology and Health Laboratory, Department of Life Sciences, Faculty of Sciences, University Ibn Tofail, B.P. 133, Kenitra, 14000, Morocco. youssef.aboussaleh@uit.ac.ma. LA - eng GR - 9386854 SF-CO/SysOrg/6/2021 34009-20-1694/H2020 ERA-NETs SUSFOOD2 and CORE Organic Cofunds/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240716 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Morocco MH - Male MH - Adult MH - Female MH - Cross-Sectional Studies MH - Middle Aged MH - *Feeding Behavior MH - Young Adult MH - Adolescent MH - Diet, Mediterranean/statistics & numerical data MH - Diet Surveys MH - Aged PMC - PMC11251386 OTO - NOTNLM OT - Food consumption patterns OT - Kenitra province OT - Mediterranean diet OT - Morocco COIS- The authors declare no competing interests. EDAT- 2024/07/17 00:41 MHDA- 2024/07/17 06:43 PMCR- 2024/07/16 CRDT- 2024/07/16 23:42 PHST- 2024/03/27 00:00 [received] PHST- 2024/07/02 00:00 [accepted] PHST- 2024/07/17 06:43 [medline] PHST- 2024/07/17 00:41 [pubmed] PHST- 2024/07/16 23:42 [entrez] PHST- 2024/07/16 00:00 [pmc-release] AID - 10.1186/s12889-024-19335-7 [pii] AID - 19335 [pii] AID - 10.1186/s12889-024-19335-7 [doi] PST - epublish SO - BMC Public Health. 2024 Jul 16;24(1):1899. doi: 10.1186/s12889-024-19335-7. PMID- 39012758 OWN - NLM STAT- MEDLINE DCOM- 20241120 LR - 20260714 IS - 1532-4303 (Electronic) IS - 0277-0903 (Linking) VI - 61 IP - 12 DP - 2024 Dec TI - Association of food folate with asthma in US children and adolescents: a cross-sectional study. PG - 1706-1714 LID - 10.1080/02770903.2024.2380509 [doi] AB - BACKGROUND: Asthma is a chronic inflammatory disease. Currently, contradictory findings exist regarding the association between food folate and asthma. Therefore, we hypothesize a positive correlation between food folate and asthma. PURPOSE: To investigate the possible relationship between food folate intake and the development of asthma in children and adolescents in the United States. METHODS: Data from the U.S. National Health and Nutrition Examination Survey (NHANES) from 2009 to 2018 were analyzed cross-sectionally by covariate adjustment using multivariate logistic regression, restricted triple spline curves, threshold effects, and stratified analyses. RESULTS: There were 8,821 participants, of whom 1,697 (19.2%) self-reported having received a diagnosis of asthma from a physician or other health professional. After accounting for potential confounders, the adjusted odds ratios (ORs) for asthma in the second (T2, 111-178 microg/day) and third (T3, >178 microg/day) groups were 1.15 (1-1.33) and 1.23 (1.04-1.46), respectively, compared with the group with the lowest food folate intake (T1, <111 microg/day). In addition, the association between food folate intake and asthma showed an inverse L-shaped curve (non-linear relationship, p = 0.003), and stratified analysis further validated the robustness of the results. The OR of asthma in subjects with food folate intake less than 263.9 microg/day was 1.002 (1.001-1.004). CONCLUSION: In children and adolescents in the United States, there is a non-linear association (inverted "L" shape) between food folate intake and asthma, with an inflection point at 263.9 micrograms per day. FAU - Du, Linjun AU - Du L AD - The Third People's Hospital of Liaocheng City, Shandong Province, China. FAU - Zhang, Xiaolan AU - Zhang X AD - The Third People's Hospital of Liaocheng City, Shandong Province, China. FAU - Wu, Cuiqing AU - Wu C AD - Maternal and Child Health Center, Chiping District, Liaocheng City, Shandong Province, China. FAU - Zhou, Rongguan AU - Zhou R AD - Zhejiang Rui'an Third People's Hospital, China. FAU - Chen, Lifang AU - Chen L AD - The Third People's Hospital of Liaocheng City, Shandong Province, China. FAU - Gui, Ruping AU - Gui R AD - Maternal and Child Health Center, Chiping District, Liaocheng City, Shandong Province, China. FAU - Wang, Wei AU - Wang W AD - Tai'an Maternal and Child Health Hospital, Shandong Province, China. FAU - An, Mouzhen AU - An M AD - Tai'an Maternal and Child Health Hospital, Shandong Province, China. FAU - Wang, Xia AU - Wang X AD - Maternal and Child Health Center, Chiping District, Liaocheng City, Shandong Province, China. LA - eng PT - Journal Article DEP - 20240725 PL - England TA - J Asthma JT - The Journal of asthma : official journal of the Association for the Care of Asthma JID - 8106454 RN - 935E97BOY8 (Folic Acid) SB - IM MH - Humans MH - *Asthma/epidemiology MH - *Folic Acid/administration & dosage MH - Cross-Sectional Studies MH - Child MH - Adolescent MH - Female MH - Male MH - United States/epidemiology MH - *Nutrition Surveys MH - Child, Preschool MH - Diet OTO - NOTNLM OT - Asthma OT - cross-sectional studies OT - food folate OT - inverse L-shaped relationships EDAT- 2024/07/16 18:42 MHDA- 2024/11/20 11:04 CRDT- 2024/07/16 12:23 PHST- 2024/11/20 11:04 [medline] PHST- 2024/07/16 18:42 [pubmed] PHST- 2024/07/16 12:23 [entrez] AID - 10.1080/02770903.2024.2380509 [doi] PST - ppublish SO - J Asthma. 2024 Dec;61(12):1706-1714. doi: 10.1080/02770903.2024.2380509. Epub 2024 Jul 25. PMID- 39012691 OWN - NLM STAT- MEDLINE DCOM- 20240716 LR - 20260623 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 13 DP - 2024 Jul 16 TI - Identifying Person-Specific Drivers of Depression in Adolescents: Protocol for a Smartphone-Based Ecological Momentary Assessment and Passive Sensing Study. PG - e43931 LID - 10.2196/43931 [doi] LID - e43931 AB - BACKGROUND: Adolescence is marked by an increasing risk of depression and is an optimal window for prevention and early intervention. Personalizing interventions may be one way to maximize therapeutic benefit, especially given the marked heterogeneity in depressive presentations. However, empirical evidence that can guide personalized intervention for youth is lacking. Identifying person-specific symptom drivers during adolescence could improve outcomes by accounting for both developmental and individual differences. OBJECTIVE: This study leverages adolescents' everyday smartphone use to investigate person-specific drivers of depression and validate smartphone-based mobile sensing data against established ambulatory methods. We describe the methods of this study and provide an update on its status. After data collection is completed, we will address three specific aims: (1) identify idiographic drivers of dynamic variability in depressive symptoms, (2) test the validity of mobile sensing against ecological momentary assessment (EMA) and actigraphy for identifying these drivers, and (3) explore adolescent baseline characteristics as predictors of these drivers. METHODS: A total of 50 adolescents with elevated symptoms of depression will participate in 28 days of (1) smartphone-based EMA assessing depressive symptoms, processes, affect, and sleep; (2) mobile sensing of mobility, physical activity, sleep, natural language use in typed interpersonal communication, screen-on time, and call frequency and duration using the Effortless Assessment of Risk States smartphone app; and (3) wrist actigraphy of physical activity and sleep. Adolescents and caregivers will complete developmental and clinical measures at baseline, as well as user feedback interviews at follow-up. Idiographic, within-subject networks of EMA symptoms will be modeled to identify each adolescent's person-specific drivers of depression. Correlations among EMA, mobile sensor, and actigraph measures of sleep, physical, and social activity will be used to assess the validity of mobile sensing for identifying person-specific drivers. Data-driven analyses of mobile sensor variables predicting core depressive symptoms (self-reported mood and anhedonia) will also be used to assess the validity of mobile sensing for identifying drivers. Finally, between-subject baseline characteristics will be explored as predictors of person-specific drivers. RESULTS: As of October 2023, 84 families were screened as eligible, of whom 70% (n=59) provided informed consent and 46% (n=39) met all inclusion criteria after completing baseline assessment. Of the 39 included families, 85% (n=33) completed the 28-day smartphone and actigraph data collection period and follow-up study visit. CONCLUSIONS: This study leverages depressed adolescents' everyday smartphone use to identify person-specific drivers of adolescent depression and to assess the validity of mobile sensing for identifying these drivers. The findings are expected to offer novel insights into the structure and dynamics of depressive symptomatology during a sensitive period of development and to inform future development of a scalable, low-burden smartphone-based tool that can guide personalized treatment decisions for depressed adolescents. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/43931. CI - (c)Mei Yi Ng, Jennifer A Frederick, Aaron J Fisher, Nicholas B Allen, Jeremy W Pettit, Dana L McMakin. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 16.07.2024. FAU - Ng, Mei Yi AU - Ng MY AUID- ORCID: 0000-0002-1399-0133 AD - Department of Psychology and Center for Children and Families, Florida International University, Miami, FL, United States. FAU - Frederick, Jennifer A AU - Frederick JA AUID- ORCID: 0000-0001-9411-4284 AD - Department of Psychology and Center for Children and Families, Florida International University, Miami, FL, United States. FAU - Fisher, Aaron J AU - Fisher AJ AUID- ORCID: 0000-0001-9754-4618 AD - Department of Psychology, University of California, Berkeley, Berkeley, CA, United States. FAU - Allen, Nicholas B AU - Allen NB AUID- ORCID: 0000-0002-1086-6639 AD - Department of Psychology, University of Oregon, Eugene, OR, United States. FAU - Pettit, Jeremy W AU - Pettit JW AUID- ORCID: 0000-0002-7426-9411 AD - Department of Psychology and Center for Children and Families, Florida International University, Miami, FL, United States. FAU - McMakin, Dana L AU - McMakin DL AUID- ORCID: 0000-0002-6954-4204 AD - Department of Psychology and Center for Children and Families, Florida International University, Miami, FL, United States. LA - eng GR - R21 MH126394/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20240716 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - Adolescent MH - *Smartphone MH - *Ecological Momentary Assessment MH - *Depression/diagnosis MH - Female MH - Male MH - Actigraphy/instrumentation/methods MH - Mobile Applications PMC - PMC11289582 OTO - NOTNLM OT - actigraphy OT - adolescents OT - depression OT - digital phenotyping OT - ecological momentary assessment OT - idiographic assessment OT - mobile sensing OT - network modeling OT - smartphones OT - treatment personalization COIS- Conflicts of Interest: NBA is the cofounder and CEO of, and has an equity interest in, Ksana Health, the company that developed and maintains the EARS platform used in this study. JWP receives royalties from New Harbinger Publications and the American Psychological Association. All other authors declare no conflicts of interest. EDAT- 2024/07/16 12:43 MHDA- 2024/07/16 18:41 PMCR- 2024/07/16 CRDT- 2024/07/16 11:53 PHST- 2023/10/05 00:00 [received] PHST- 2024/02/07 00:00 [accepted] PHST- 2024/02/06 00:00 [revised] PHST- 2024/07/16 18:41 [medline] PHST- 2024/07/16 12:43 [pubmed] PHST- 2024/07/16 11:53 [entrez] PHST- 2024/07/16 00:00 [pmc-release] AID - v13i1e43931 [pii] AID - 10.2196/43931 [doi] PST - epublish SO - JMIR Res Protoc. 2024 Jul 16;13:e43931. doi: 10.2196/43931. PMID- 39012434 OWN - NLM STAT- MEDLINE DCOM- 20241003 LR - 20261010 IS - 1522-1709 (Electronic) IS - 1520-9512 (Linking) VI - 28 IP - 5 DP - 2024 Oct TI - Two-dimensional facial photography for assessment of craniofacial morphology in sleep breathing disorders: a systematic review. PG - 1889-1897 LID - 10.1007/s11325-024-03103-3 [doi] AB - PURPOSE: Craniofacial morphology is integral to Sleep Breathing Disorders (SBD), particularly Obstructive Sleep Apnea (OSA), informing treatment strategies. This review assesses the utility of two-dimensional (2D) photogrammetry in evaluating these metrics among OSA patients. METHODS: Following PRISMA guidelines, a systematic review was conducted. PubMed, Embase, and Lilacs databases were systematically searched for studies utilizing 2D photography in SBD. Findings were narratively synthesized. RESULTS: Thirteen studies involving 2,328 patients were included. Significant correlations were found between craniofacial measurements-specifically neck parameters and facial width-and OSA severity, even after BMI adjustment. Ethnic disparities in craniofacial morphology were observed, with photogrammetry effective in predicting OSA in Caucasians and Asians, though data for other ethnicities were limited. Pediatric studies suggest the potential of craniofacial measurements as predictors of childhood OSA, with certain caveats. CONCLUSION: 2D photogrammetry emerges as a practical and non-invasive tool correlating with OSA severity across diverse populations. However, further validation in various ethnic cohorts is essential to enhance the generalizability of these findings. CI - (c) 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG. FAU - Mamede, Isadora AU - Mamede I AUID- ORCID: 0009-0005-7154-8692 AD - Federal University of Sao Joao del-Rei, Centro Oeste Campus, Divinopolis, Minas Gerais, Brazil. isamamede1@gmail.com. FAU - Lacerda, Sophia Paiva Silveira AU - Lacerda SPS AD - Federal University of Sao Joao del-Rei, Centro Oeste Campus, Divinopolis, Minas Gerais, Brazil. FAU - Alvares, Alice Veloso AU - Alvares AV AD - Federal University of Sao Joao del-Rei, Centro Oeste Campus, Divinopolis, Minas Gerais, Brazil. FAU - Rodrigues, Anna Barbara Veloso Tomaz AU - Rodrigues ABVT AD - Federal University of Sao Joao del-Rei, Centro Oeste Campus, Divinopolis, Minas Gerais, Brazil. FAU - Silva, Bruna de Souza AU - Silva BS AD - Federal University of Sao Joao del-Rei, Centro Oeste Campus, Divinopolis, Minas Gerais, Brazil. FAU - Andrade, Bruna Oliveira AU - Andrade BO AD - Federal University of Sao Joao del-Rei, Centro Oeste Campus, Divinopolis, Minas Gerais, Brazil. FAU - Martins, Luciana Menezes Nogueira AU - Martins LMN AD - Federal University of Sao Joao del-Rei, Centro Oeste Campus, Divinopolis, Minas Gerais, Brazil. LA - eng PT - Journal Article PT - Systematic Review DEP - 20240716 PL - Germany TA - Sleep Breath JT - Sleep & breathing = Schlaf & Atmung JID - 9804161 SB - IM MH - Humans MH - *Face/anatomy & histology MH - *Photogrammetry/methods MH - Sleep Apnea Syndromes/diagnosis MH - *Sleep Apnea, Obstructive/diagnosis OTO - NOTNLM OT - Craniofacial morphology OT - Obstructive sleep apnea OT - Photogrammetry OT - Systematic review EDAT- 2024/07/16 12:44 MHDA- 2024/10/04 07:19 CRDT- 2024/07/16 11:06 PHST- 2024/03/22 00:00 [received] PHST- 2024/07/01 00:00 [accepted] PHST- 2024/05/29 00:00 [revised] PHST- 2024/10/04 07:19 [medline] PHST- 2024/07/16 12:44 [pubmed] PHST- 2024/07/16 11:06 [entrez] AID - 10.1007/s11325-024-03103-3 [pii] AID - 10.1007/s11325-024-03103-3 [doi] PST - ppublish SO - Sleep Breath. 2024 Oct;28(5):1889-1897. doi: 10.1007/s11325-024-03103-3. Epub 2024 Jul 16. PMID- 39011974 OWN - NLM STAT- MEDLINE DCOM- 20250423 LR - 20250423 IS - 1945-7197 (Electronic) IS - 0021-972X (Linking) VI - 110 IP - 5 DP - 2025 Apr 22 TI - Machine Learning-Based Prediction of Large-for-Gestational-Age Infants in Mothers With Gestational Diabetes Mellitus. PG - e1631-e1639 LID - 10.1210/clinem/dgae475 [doi] AB - CONTEXT: Large-for-gestational-age (LGA), one of the most common complications of gestational diabetes mellitus (GDM), has become a global concern. The predictive performance of common continuous glucose monitoring (CGM) metrics for LGA is limited. OBJECTIVE: We aimed to develop and validate an artificial intelligence (AI)-based model to determine the probability of women with GDM giving birth to LGA infants during pregnancy using CGM measurements together with demographic data and metabolic indicators. METHODS: A total of 371 women with GDM from a prospective cohort at a university hospital were included. CGM was performed during 20 to 34 gestational weeks, and glycemic fluctuations were evaluated and visualized in women with GDM who gave birth to LGA and non-LGA infants. A convolutional neural network (CNN)-based fusion model was developed to predict LGA. Comparisons among the novel fusion model and 3 conventional models were made using the area under the receiver operating characteristic curve (AUCROC) and accuracy. RESULTS: Overall, 76 (20.5%) out of 371 GDM women developed LGA neonates. The visualized 24-hour glucose profiles differed at midmorning. This difference was consistent among subgroups categorized by pregestational body mass index, therapeutic protocol, and CGM administration period. The AI-based fusion prediction model using 24-hour CGM data and 15 clinical variables for LGA prediction (AUCROC 0.852; 95% CI, 0.680-0.966; accuracy 84.4%) showed superior discriminative power compared with the 3 classic models. CONCLUSION: We demonstrated better performance in predicting LGA infants among women with GDM using the AI-based fusion model. The characteristics of the CGM profiles allowed us to determine the appropriate window for intervention. CI - (c) The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. See the journal About page for additional terms. FAU - Kang, Mei AU - Kang M AD - Clinical Research Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. AD - Department of Epidemiology, Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai 200032, China. FAU - Zhu, Chengguang AU - Zhu C AD - MoE Key Lab of Artificial Intelligence, AI Institute, Shanghai Jiao Tong University, Shanghai 200240, China. FAU - Lai, Mengyu AU - Lai M AD - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. FAU - Weng, Jianrong AU - Weng J AD - Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. FAU - Zhuang, Yan AU - Zhuang Y AD - Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. FAU - He, Huichen AU - He H AD - Clinical Research Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. FAU - Qiu, Yan AU - Qiu Y AD - Clinical Research Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. FAU - Wu, Yixia AU - Wu Y AD - Clinical Research Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. FAU - Qi, Zhangxuan AU - Qi Z AD - Center for Medical Artificial Intelligence and Engineering, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. FAU - Zhang, Weixia AU - Zhang W AD - MoE Key Lab of Artificial Intelligence, AI Institute, Shanghai Jiao Tong University, Shanghai 200240, China. FAU - Xu, Xianming AU - Xu X AUID- ORCID: 0000-0003-4431-4581 AD - Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. FAU - Zhu, Yanhong AU - Zhu Y AUID- ORCID: 0000-0002-1280-7923 AD - Clinical Research Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. FAU - Wang, Yufan AU - Wang Y AUID- ORCID: 0000-0001-9614-3986 AD - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. FAU - Yang, Xiaokang AU - Yang X AD - MoE Key Lab of Artificial Intelligence, AI Institute, Shanghai Jiao Tong University, Shanghai 200240, China. LA - eng GR - 2021YFC2501600/National Key Research and Development Program of China/ GR - 21Y11904800/Shanghai Science and Technology Commission Foundation/ GR - SHDC2022CRS028/The Shanghai Hospital Development Center/ GR - 22DZ2292300/Shanghai Municipal Committee of Science and Technology/ GR - Fundamental Research Funds for the Central Universities/ GR - 2021SHZDZX0102/Shanghai Municipal Science and Technology Major Project/ GR - 2022YFF1202600/National Key R&D Program of China/ PT - Journal Article PL - United States TA - J Clin Endocrinol Metab JT - The Journal of clinical endocrinology and metabolism JID - 0375362 RN - 0 (Blood Glucose) SB - IM MH - Humans MH - Female MH - *Diabetes, Gestational/blood/diagnosis MH - Pregnancy MH - *Machine Learning MH - Adult MH - Infant, Newborn MH - Prospective Studies MH - Blood Glucose/analysis MH - *Fetal Macrosomia/diagnosis/etiology/epidemiology MH - Gestational Age MH - Predictive Value of Tests MH - Blood Glucose Self-Monitoring MH - Birth Weight MH - Infant, Large for Gestational Age OTO - NOTNLM OT - continuous glucose monitoring OT - gestational diabetes mellitus OT - glycemic profile OT - large-for-gestational age OT - machine learning OT - prediction model EDAT- 2024/07/16 12:44 MHDA- 2025/04/23 12:27 CRDT- 2024/07/16 07:43 PHST- 2024/04/05 00:00 [received] PHST- 2025/04/23 12:27 [medline] PHST- 2024/07/16 12:44 [pubmed] PHST- 2024/07/16 07:43 [entrez] AID - 7714516 [pii] AID - 10.1210/clinem/dgae475 [doi] PST - ppublish SO - J Clin Endocrinol Metab. 2025 Apr 22;110(5):e1631-e1639. doi: 10.1210/clinem/dgae475. PMID- 39009137 OWN - NLM STAT- MEDLINE DCOM- 20240905 LR - 20260428 IS - 1938-3207 (Electronic) IS - 0002-9165 (Linking) VI - 120 IP - 3 DP - 2024 Sep TI - Optimal gestational weight change associated with improved perinatal outcomes in women with gestational diabetes mellitus: a population-based study in the United States. PG - 737-745 LID - S0002-9165(24)00604-X [pii] LID - 10.1016/j.ajcnut.2024.07.008 [doi] AB - BACKGROUND: Optimal gestational weight change (GWC) is little known among pregnant women with gestational diabetes mellitus (GDM). OBJECTIVES: This study aimed to explore the optimal GWC ranges for women with GDM and validate these ranges compared with the Institute of Medicine (IOM) guidelines. METHODS: A population-based cohort study using natality data from the National Center for Health Statistics in the United States included 1,338,460 mother-infant pairs with GDM from 2014 to 2020. Poisson regression models were performed to identify GWC ranges (GDM targets) associated with acceptable risks (<10% increase) for a severity-weighted composite outcome including preterm birth (PTB) <37 wk, large for gestational age (LGA, birthweight >90th percentile) and small for gestational age (SGA, birthweight <10th percentile). These targets were validated in individual outcomes including PTB, LGA, SGA, hypertensive disorders of pregnancy, neonatal intensive care unit admission, and neonatal respiratory morbidity, and compared with the IOM guidelines using logistic regression models with population-attributable fractions (PAFs) calculated. RESULTS: The severity-weighted composite outcome had a U-shaped or a J-shaped relationship with GWC across body mass index categories. The GDM targets were 14.1 to 20.3 kg, 9.0 to 17.0 kg, 4.8 to 13.8 kg, -0.8 to 10.8 kg, -2.4 to 8.2 kg, and -8.3 to 6.0 kg for underweight, normal weight, overweight, class 1 obesity, class 2 obesity, and class 3 obesity, respectively. GWC outside the GDM or the IOM targets was associated with increased adverse perinatal outcomes in validation analyses. PAFs indicated that the IOM guidelines reduced a similar or higher proportion of adverse perinatal outcomes compared with the GDM targets for women with GDM, except for those with class 2 and 3 obesity. CONCLUSIONS: The IOM guidelines are generally applicable for women with GDM, except for women with moderate and severe obesity. The optimal GWC ranges for women with GDM and moderate to severe obesity may be lower than the IOM guidelines. CI - Copyright (c) 2024 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Huang, Xuqiong AU - Huang X AD - Medical Administration Division, Huadu District People's Hospital of Guangzhou, Guangdong, China. FAU - Fan, Dazhi AU - Fan D AD - Foshan Institute of Fetal Medicine, Maternal & Child Health Hospital of Foshan, Guangdong, China; Department of Obstetrics, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China. FAU - Li, Weijiang AU - Li W AD - Medical Administration Division, Huadu District People's Hospital of Guangzhou, Guangdong, China. FAU - Chen, Gengdong AU - Chen G AD - Foshan Institute of Fetal Medicine, Maternal & Child Health Hospital of Foshan, Guangdong, China; Department of Obstetrics, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China. FAU - Li, Pengsheng AU - Li P AD - Foshan Institute of Fetal Medicine, Maternal & Child Health Hospital of Foshan, Guangdong, China; Department of Obstetrics, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China. FAU - Rao, Jiaming AU - Rao J AD - Foshan Institute of Fetal Medicine, Maternal & Child Health Hospital of Foshan, Guangdong, China; Department of Obstetrics, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China. FAU - Lan, Shiyan AU - Lan S AD - Department of Obstetrics, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China. FAU - Wang, Lijuan AU - Wang L AD - Department of Obstetrics, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China. FAU - Lin, Dongxin AU - Lin D AD - Foshan Institute of Fetal Medicine, Maternal & Child Health Hospital of Foshan, Guangdong, China; Department of Obstetrics, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China. Electronic address: lindongxin21@outlook.com. LA - eng PT - Journal Article DEP - 20240714 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Diabetes, Gestational/epidemiology MH - United States/epidemiology MH - Adult MH - *Pregnancy Outcome MH - *Gestational Weight Gain MH - Cohort Studies MH - Infant, Newborn MH - Birth Weight MH - Body Mass Index MH - Premature Birth/epidemiology MH - Infant, Small for Gestational Age OTO - NOTNLM OT - gestational diabetes mellitus OT - gestational weight change OT - large for gestational age OT - perinatal outcomes OT - preterm birth OT - small for gestational age EDAT- 2024/07/16 00:41 MHDA- 2024/09/05 06:42 CRDT- 2024/07/15 20:04 PHST- 2024/03/07 00:00 [received] PHST- 2024/07/04 00:00 [revised] PHST- 2024/07/10 00:00 [accepted] PHST- 2024/09/05 06:42 [medline] PHST- 2024/07/16 00:41 [pubmed] PHST- 2024/07/15 20:04 [entrez] AID - S0002-9165(24)00604-X [pii] AID - 10.1016/j.ajcnut.2024.07.008 [doi] PST - ppublish SO - Am J Clin Nutr. 2024 Sep;120(3):737-745. doi: 10.1016/j.ajcnut.2024.07.008. Epub 2024 Jul 14. PMID- 39006391 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240716 IS - 2055-7647 (Print) IS - 2055-7647 (Electronic) IS - 2055-7647 (Linking) VI - 10 IP - 3 DP - 2024 TI - Cross-validation of the Canadian Assessment of Physical Literacy second edition (CAPL-2) for Spanish children. PG - e001971 LID - 10.1136/bmjsem-2024-001971 [doi] LID - e001971 AB - BACKGROUND/OBJECTIVE: This study aimed to explore physical literacy (PL) using the Canadian Assessment of Physical Literacy, second edition (CAPL-2), adapt it to the Spanish context and provide evidence of its validity for use in Spanish children aged 8-12. METHODS: A total of 280 students (150 girls, mean age 10.5+/-0.9 years) from Extremadura (Spain) completed the CAPL-2. Means and SDs were used to present CAPL-2 scores according to age and sex, as well as frequencies to place participants at different PL levels. Confirmatory factor analysis (CFA) was conducted to establish the best model fit for the data. RESULTS: The median PL of Spanish children was progressing, and girls had a lower PL than boys for all ages except 12 years. The results supported a four-domain model for the CAPL-2 Spanish version and reported good fit indices after CFA (chi(2) per df ratio=1.118; P (chi(2))=0.256; root mean square error of approximation=0.021; comparative fit index=0.987; Tuker-Lewis index=0.991; normed fit index=0.895). CONCLUSION: The CAPL-2 model is a valid and reliable instrument for Spanish children aged 8-12. It represents the first tool that assesses PL in Spanish children, covering the domains of motivation and confidence, physical competence, knowledge and understanding, and daily behaviour. It may be relevant for all professionals related to physical activity, education and the health field. CI - Copyright (c) Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Mendoza Munoz, Maria AU - Mendoza Munoz M AD - University of Extremadura, Badajoz, Spain. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AUID- ORCID: 0000-0002-7412-7624 AD - One Health Research Group, Universidad de Las Americas, Quito, Ecuador. FAU - Pastor-Cisneros, Raquel AU - Pastor-Cisneros R AUID- ORCID: 0000-0001-7305-6783 AD - University of Extremadura, Badajoz, Spain. FAU - Castillo Paredes, Antonio AU - Castillo Paredes A AD - Universidad de Las Americas, Santiago, Chile. FAU - Urbano Mairena, Javier AU - Urbano Mairena J AD - University of Extremadura, Badajoz, Spain. FAU - Tremblay, Mark AU - Tremblay M AD - Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada. AD - Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada. FAU - Carlos Vivas, Jorge AU - Carlos Vivas J AD - University of Extremadura, Badajoz, Spain. LA - eng PT - Journal Article DEP - 20240711 PL - England TA - BMJ Open Sport Exerc Med JT - BMJ open sport & exercise medicine JID - 101681007 PMC - PMC11243216 OTO - NOTNLM OT - Child OT - Education OT - Physical activity OT - Validity OT - Young COIS- None declared. EDAT- 2024/07/15 06:42 MHDA- 2024/07/15 06:43 PMCR- 2024/07/11 CRDT- 2024/07/15 05:30 PHST- 2024/06/23 00:00 [accepted] PHST- 2024/07/15 06:43 [medline] PHST- 2024/07/15 06:42 [pubmed] PHST- 2024/07/15 05:30 [entrez] PHST- 2024/07/11 00:00 [pmc-release] AID - bmjsem-2024-001971 [pii] AID - 10.1136/bmjsem-2024-001971 [doi] PST - epublish SO - BMJ Open Sport Exerc Med. 2024 Jul 11;10(3):e001971. doi: 10.1136/bmjsem-2024-001971. eCollection 2024. PMID- 39005755 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240716 IS - 1178-7090 (Print) IS - 1178-7090 (Electronic) IS - 1178-7090 (Linking) VI - 17 DP - 2024 TI - Menstrual Cramps in Anovulatory versus Normally Ovulatory Cycles - SARS-COV-2 Pandemic Daily Data Plus a Meta-Analysis of Cramps and Anovulation. PG - 2363-2374 LID - 10.2147/JPR.S457484 [doi] AB - PURPOSE: It is asserted that primary dysmenorrhea/menstrual cramps only occur in ovulatory menstrual cycles. Our first objective was to present detailed menstrual cramps information in normally ovulatory versus anovulatory cycles from a single-cycle cohort study during the SARS-CoV-2 Pandemic. Secondly, we reviewed the literature for cohort studies documenting both menstrual cramps and ovulation. PARTICIPANTS AND METHODS: The Menstruation and Ovulation Study 2 recruited 108 women ages 19-35 years to a prospective, observational single-cycle study, recording cramps daily (0-4 scale) in the Menstrual Cycle Diary(c) and assessing normal ovulation (luteal length >/=10 days) by the validated Quantitative Basal Temperature(c) (Mean Temperature Method). We searched databases for << primary dysmenorrhea >> / >> menstrual cramps >>; << menstrual cycles >>; << anovulation >>, finding four valid publications. RESULTS: In 75 women/cycles during the Pandemic, mean age was 28.5, body mass index 23.5, and higher education (16 years); 40 normally ovulatory and 35 anovulatory cycles had similar lengths (29.5-30.0 days), respectively (P=0.571). However, anovulatory cycles recorded significantly worse menstrual cramps versus normally ovulatory cycles; anovulatory median intensity was 1.9 versus 1.6, and Cramp Score was 8 versus 6 in normally ovulatory cycles (P=0.017). Four publications in 273 women (991 cycles) showed cramps in both anovulatory and ovulatory cycles; three were in adolescent/young adult women, one of which documented a significantly greater percentage of cramps in ovulatory cycles. The 694 cycles in premenopausal women (20-41 years) showed similar percentages of symptomatic cramps in cycles of both ovulatory types. Meta-analysis documented significantly higher cramp prevalence in ovulatory cycles (OR 2.10; 95% CI 1.31, 3.37; P=0.002). CONCLUSION: This is the first documentation of more intense and frequent cramps in anovulatory cycles. However, meta-analysis showing the presence of symptomatic cramps in both ovulatory and anovulatory cycles documented they were twice as prevalent in ovulatory menstrual cycles. CI - (c) 2024 Mann et al. FAU - Mann, Gurleen AU - Mann G AD - University of British Columbia, Vancouver, British Columbia, Canada. FAU - Shirin, Sonia AU - Shirin S AD - Centre for Menstrual Cycle and Ovulation Research, University of British Columbia, Vancouver, British Columbia, Canada. AD - British Columbia Women's Health Research Institute, Vancouver, British Columbia, Canada. FAU - Bann, Sewon AU - Bann S AD - Centre for Menstrual Cycle and Ovulation Research, University of British Columbia, Vancouver, British Columbia, Canada. AD - British Columbia Women's Health Research Institute, Vancouver, British Columbia, Canada. AD - Division of Endocrinology and Metabolism, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. FAU - Yong, Paul J AU - Yong PJ AUID- ORCID: 0000-0001-5521-3052 AD - Centre for Menstrual Cycle and Ovulation Research, University of British Columbia, Vancouver, British Columbia, Canada. AD - British Columbia Women's Health Research Institute, Vancouver, British Columbia, Canada. AD - Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada. FAU - Kalidasan, Dharani AU - Kalidasan D AD - Centre for Menstrual Cycle and Ovulation Research, University of British Columbia, Vancouver, British Columbia, Canada. FAU - Goshtasebi, Azita AU - Goshtasebi A AD - Centre for Menstrual Cycle and Ovulation Research, University of British Columbia, Vancouver, British Columbia, Canada. AD - British Columbia Women's Health Research Institute, Vancouver, British Columbia, Canada. FAU - Prior, Jerilynn C AU - Prior JC AUID- ORCID: 0000-0003-3232-0597 AD - Centre for Menstrual Cycle and Ovulation Research, University of British Columbia, Vancouver, British Columbia, Canada. AD - British Columbia Women's Health Research Institute, Vancouver, British Columbia, Canada. AD - Division of Endocrinology and Metabolism, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. AD - School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. LA - eng PT - Journal Article DEP - 20240710 PL - New Zealand TA - J Pain Res JT - Journal of pain research JID - 101540514 PMC - PMC11246634 OAB - "Worse Menstrual Cramps in Anovulatory Cycles". Medicine has long believed that menstrual cramps only occur in ovulatory menstrual cycles that release an egg and have high progesterone levels that decrease before the next period. The notion was that dropping progesterone levels triggered release of prostaglandins that cause the pain and uterus muscle contractions of menstrual cramps. This research studied 75 community women aged 19-35 years for a single cycle during COVID-19. Forty women had normally ovulatory cycles and 35 had anovulatory cycles with a similar mean cycle length of 29.7 days. Women in both groups were similar in age, weight, education and other reproductive characteristics. Women recorded Menstrual Cycle Diary(c) daily experiences for cramp presence and intensity (scored 0-4). Ovulation was documented by daily first morning temperatures analyzed by the valid Quantitative Basal Temperature(c) method. Results showed menstrual cramps occurred in both normally ovulatory and anovulatory cycles. Surprisingly, anovulatory compared with ovulatory cycles had cramps that lasted longer (4 rather than 3 days), were more intense (1.9 versus 1.6) and with significantly higher Cramp Scores (of 8 versus 6). We also found four other published studies showing cramps occurred in both anovulatory and ovulatory cycles. A meta-analysis of these, however, showed that cramps were twice as frequent in ovulatory cycles. These results matter because they stimulate the search for more accurate understandings of why menstrual cramps occur. They will likely stimulate more effective therapies for the rare, intense menstrual cramps that currently are not effectively treated by anti-inflammatory medicines such as ibuprofen. OABL- eng OTO - NOTNLM OT - adolescent OT - menstrual cycles OT - menstrual pain OT - ovulation OT - premenopause OT - primary dysmenorrhea COIS- The authors report no conflicts of interest in this work. EDAT- 2024/07/15 06:42 MHDA- 2024/07/15 06:43 PMCR- 2024/07/10 CRDT- 2024/07/15 05:21 PHST- 2024/01/01 00:00 [received] PHST- 2024/06/09 00:00 [accepted] PHST- 2024/07/15 06:43 [medline] PHST- 2024/07/15 06:42 [pubmed] PHST- 2024/07/15 05:21 [entrez] PHST- 2024/07/10 00:00 [pmc-release] AID - 457484 [pii] AID - 10.2147/JPR.S457484 [doi] PST - epublish SO - J Pain Res. 2024 Jul 10;17:2363-2374. doi: 10.2147/JPR.S457484. eCollection 2024. PMID- 39004510 OWN - NLM STAT- MEDLINE DCOM- 20260108 LR - 20260813 IS - 1468-3318 (Electronic) IS - 0964-4563 (Print) IS - 0964-4563 (Linking) VI - 35 IP - 1 DP - 2026 Jan 8 TI - Variability in self-reported and biomarker-derived tobacco smoke exposure patterns among individuals who do not smoke by poverty income ratio in the USA. PG - 7-12 LID - 10.1136/tc-2023-058512 [doi] AB - INTRODUCTION: Tobacco smoke exposure (TSE) among individuals who do not smoke has declined in the USA, however, gaps remain in understanding how TSE patterns across indoor venues-including in homes, cars, workplaces, hospitality venues, and other areas-contribute to TSE disparities by income level. METHODS: We obtained data on adults (ages 18+, N=9909) and adolescents (ages 12-17, N=2065) who do not smoke from the National Health and Nutrition Examination Survey, 2013-2018. We examined the prevalence of self-reported, venue-specific TSE in each sample, stratified by poverty income ratio (PIR) quartile. We used linear regression models with a log-transformed outcome variable to explore associations between self-reported TSE and serum cotinine. We further explored the probability of detectable cotinine among individuals who reported no recent TSE, stratified by PIR. RESULTS: Self-reported TSE was highest in cars (prevalence=6.2% among adults, 14.2% among adolescents). TSE in own homes was the most strongly associated with differences in log cotinine levels (beta for adults=1.92, 95% CI=1.52 to 2.31; beta for adolescents=2.37 95% CI=2.07 to 2.66), and the association between home exposure and cotinine among adults was most pronounced in the lowest PIR quartile. There was an income gradient with regard to the probability of detectable cotinine among both adults and adolescents who did not report recent TSE. CONCLUSIONS: Homes and vehicles remain priority venues for addressing persistent TSE among individuals who do not smoke in the USA. TSE survey measures may have differential validity across population subgroups. CI - (c) Author(s) (or their employer(s)) 2026. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Titus, Andrea R AU - Titus AR AUID- ORCID: 0000-0001-7586-643X AD - Department of Population Health, New York University Grossman School of Medicine, New York, NY, USA Andrea.Titus@nyulangone.org. FAU - Shelley, Donna AU - Shelley D AD - School of Global Public Health, New York University, New York, NY, USA. FAU - Thorpe, Lorna E AU - Thorpe LE AD - Department of Population Health, New York University Grossman School of Medicine, New York, NY, USA. LA - eng GR - L60 HL159769/HL/NHLBI NIH HHS/United States GR - P2C ES033423/ES/NIEHS NIH HHS/United States GR - R01 CA220591/CA/NCI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260108 PL - England TA - Tob Control JT - Tobacco control JID - 9209612 RN - 0 (Tobacco Smoke Pollution) RN - K5161X06LL (Cotinine) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Adolescent MH - Self Report MH - Male MH - Female MH - *Tobacco Smoke Pollution/statistics & numerical data/analysis MH - Adult MH - United States/epidemiology MH - Cotinine/blood MH - Middle Aged MH - *Poverty/statistics & numerical data MH - Young Adult MH - *Income/statistics & numerical data MH - Biomarkers/blood MH - Nutrition Surveys MH - Child MH - Prevalence MH - Aged PMC - PMC11729467 MID - NIHMS2013373 OTO - NOTNLM OT - Disparities OT - Secondhand smoke OT - Socioeconomic status COIS- Competing interests: None declared. EDAT- 2024/07/15 00:41 MHDA- 2026/01/09 03:40 PMCR- 2027/01/08 CRDT- 2024/07/14 21:13 PHST- 2023/11/20 00:00 [received] PHST- 2024/06/29 00:00 [accepted] PHST- 2026/01/09 03:40 [medline] PHST- 2024/07/15 00:41 [pubmed] PHST- 2024/07/14 21:13 [entrez] PHST- 2027/01/08 00:00 [pmc-release] AID - tc-2023-058512 [pii] AID - 10.1136/tc-2023-058512 [doi] PST - epublish SO - Tob Control. 2026 Jan 8;35(1):7-12. doi: 10.1136/tc-2023-058512. PMID- 39003169 OWN - NLM STAT- MEDLINE DCOM- 20240920 LR - 20251002 IS - 1878-1861 (Electronic) IS - 1440-2440 (Print) IS - 1878-1861 (Linking) VI - 27 IP - 10 DP - 2024 Oct TI - Concurrent validity of the Global Physical Activity Questionnaire to accelerometry in Hispanic/Latino adults: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL). PG - 708-715 LID - S1440-2440(24)00219-6 [pii] LID - 10.1016/j.jsams.2024.06.005 [doi] AB - OBJECTIVES: The validity of the Global Physical Activity Questionnaire has not been thoroughly evaluated among Hispanics/Latinos. In this cross-sectional study, we assessed the concurrent validity and correlates of discordance of the Global Physical Activity Questionnaire by comparing it to accelerometry in estimating sedentary behavior, moderate-to-vigorous physical activity, and meeting United States physical activity guidelines by sociodemographic, behavioral, and health characteristics. DESIGN: The Hispanic Community Health Study/Study of Latinos is a 4-site cohort study of United States adults aged 18-74 years enrolled from 2008 to 2011. METHODS: Participants (n = 11,873) completed the Global Physical Activity Questionnaire and wore an accelerometer for 1 week. Lin's concordance and Pearson correlations assessed concurrent validity between self-reported and accelerometry-assessed measures of sedentary behavior and moderate-to-vigorous physical activity. Kappa coefficients assessed agreement of meeting physical activity guidelines. Linear and logistic regression models identified correlates of discordance. RESULTS: The overall Lin's concordance and Pearson correlations between the Global Physical Activity Questionnaire and accelerometry estimates were 0.10 (95 % confidence interval 0.09, 0.12) and 0.24 (0.21, 0.27) for sedentary behavior, and 0.04 (0.03, 0.05) and 0.18 (0.15, 0.22) for moderate-to-vigorous physical activity, respectively. Agreement was poor for meeting the physical activity guideline classifications (Kappa coefficients: 0.12 to 0.26). Over a 16-hour day, sedentary behavior was under-reported by 3.8 h and moderate-to-vigorous physical activity was over-reported by 1.9 h. CONCLUSIONS: The concurrent validity of the Global Physical Activity Questionnaire in measuring moderate-to-vigorous physical activity and sedentary behavior when compared to accelerometry was poor among Hispanic/Latino adults. CI - Copyright (c) 2024 Elsevier Ltd. All rights reserved. FAU - Vazquez, Jesus E AU - Vazquez JE AD - Department of Biostatistics, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, United States. Electronic address: jesusvaz@ad.unc.edu. FAU - Sotres-Alvarez, Daniela AU - Sotres-Alvarez D AD - Department of Biostatistics, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, United States. FAU - Carlson, Jordan A AU - Carlson JA AD - Center for Children's Health Lifestyles & Nutrition, Children's Mercy Kansas City, United States. FAU - Gallo, Linda C AU - Gallo LC AD - Department of Pediatrics, Children's Mercy Kansas City and University of Missouri Kansas City, United States. FAU - Talavera, Gregory A AU - Talavera GA AD - Department of Psychology, San Diego State University, United States. FAU - Castaneda, Sheila F AU - Castaneda SF AD - Department of Psychology, San Diego State University, United States. FAU - Evenson, Kelly R AU - Evenson KR AD - Department of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, United States. LA - eng GR - R01 NS131225/NS/NINDS NIH HHS/United States GR - P30 ES010126/ES/NIEHS NIH HHS/United States GR - HHSN268201300003I/HL/NHLBI NIH HHS/United States GR - N01 HC065233/HL/NHLBI NIH HHS/United States GR - N01 HC065235/HL/NHLBI NIH HHS/United States GR - N01 HC065234/HL/NHLBI NIH HHS/United States GR - N01 HC065237/HL/NHLBI NIH HHS/United States GR - T32 ES007018/ES/NIEHS NIH HHS/United States GR - N01 HC065236/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Validation Study DEP - 20240621 PL - Australia TA - J Sci Med Sport JT - Journal of science and medicine in sport JID - 9812598 SB - IM MH - Humans MH - *Accelerometry MH - Adult MH - Middle Aged MH - *Hispanic or Latino MH - Female MH - Male MH - *Exercise MH - *Sedentary Behavior/ethnology MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - Young Adult MH - Aged MH - Adolescent MH - United States MH - Self Report MH - Reproducibility of Results PMC - PMC11534078 MID - NIHMS2011599 OTO - NOTNLM OT - Accelerometer OT - Epidemiology OT - Physical activity assessment OT - Population health OT - Sedentary behavior OT - Validity COIS- Declaration of interest statement The accelerometer used in this study was an Actical device (version B-1, model 198-0200-03, 32 Hz) which is not considered a commercial product. This manuscript does not involve consultancies, stock ownership, or other equity interests or patent-licensing arrangements. The authors declare no conflicts of interest. EDAT- 2024/07/14 02:43 MHDA- 2024/09/20 11:30 PMCR- 2025/10/01 CRDT- 2024/07/13 21:58 PHST- 2024/01/17 00:00 [received] PHST- 2024/05/30 00:00 [revised] PHST- 2024/06/17 00:00 [accepted] PHST- 2024/09/20 11:30 [medline] PHST- 2024/07/14 02:43 [pubmed] PHST- 2024/07/13 21:58 [entrez] PHST- 2025/10/01 00:00 [pmc-release] AID - S1440-2440(24)00219-6 [pii] AID - 10.1016/j.jsams.2024.06.005 [doi] PST - ppublish SO - J Sci Med Sport. 2024 Oct;27(10):708-715. doi: 10.1016/j.jsams.2024.06.005. Epub 2024 Jun 21. PMID- 39000984 OWN - NLM STAT- MEDLINE DCOM- 20240713 LR - 20240715 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 24 IP - 13 DP - 2024 Jun 28 TI - Multilayer Perceptron-Based Wearable Exercise-Related Heart Rate Variability Predicts Anxiety and Depression in College Students. LID - 10.3390/s24134203 [doi] LID - 4203 AB - (1) Background: This study aims to investigate the correlation between heart rate variability (HRV) during exercise and recovery periods and the levels of anxiety and depression among college students. Additionally, the study assesses the accuracy of a multilayer perceptron-based HRV analysis in predicting these emotional states. (2) Methods: A total of 845 healthy college students, aged between 18 and 22, participated in the study. Participants completed self-assessment scales for anxiety and depression (SAS and PHQ-9). HRV data were collected during exercise and for a 5-min period post-exercise. The multilayer perceptron neural network model, which included several branches with identical configurations, was employed for data processing. (3) Results: Through a 5-fold cross-validation approach, the average accuracy of HRV in predicting anxiety levels was 89.3% for no anxiety, 83.6% for mild anxiety, and 74.9% for moderate to severe anxiety. For depression levels, the average accuracy was 90.1% for no depression, 84.2% for mild depression, and 82.1% for moderate to severe depression. The predictive R-squared values for anxiety and depression scores were 0.62 and 0.41, respectively. (4) Conclusions: The study demonstrated that HRV during exercise and recovery in college students can effectively predict levels of anxiety and depression. However, the accuracy of score prediction requires further improvement. HRV related to exercise can serve as a non-invasive biomarker for assessing psychological health. FAU - Li, Xiongfeng AU - Li X AD - Department of Physical Educantion, Xinzhou Normal University, Xinzhou 034000, China. FAU - Zou, Limin AU - Zou L AD - College of Physical Educantion, Jinggangshan University, Ji'an 343009, China. FAU - Li, Haojie AU - Li H AUID- ORCID: 0000-0002-4997-9083 AD - School of Physical Educantion and Sports, Beijing Normal University, Beijing 100875, China. LA - eng GR - Subject No. (TY20111)/the Humanities and Social Sciences Research Program for Jiangxi Universities (Jiangxi Provincial Department of Education), Research on the Construction of Body-Medicine Integration Models and Implementation Paths for Adolescent Health Promotion,/ GR - NO.J20231135/Shanxi Provincial Higher Education General Teaching Reform and Innovation Project "Explora-tion of the teaching practice of traditional national physical education in colleges and universities from the perspective of building a solid Chinese national comm/ PT - Journal Article DEP - 20240628 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - *Heart Rate/physiology MH - *Anxiety/physiopathology/diagnosis MH - *Exercise/physiology MH - *Students/psychology MH - Male MH - *Depression/physiopathology/diagnosis MH - Young Adult MH - Female MH - Adolescent MH - *Wearable Electronic Devices MH - *Neural Networks, Computer MH - Universities MH - Adult PMC - PMC11244370 OTO - NOTNLM OT - anxiety OT - college students OT - depression OT - exercise OT - heart rate variability OT - multilayer perceptron COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/07/13 07:41 MHDA- 2024/07/13 07:42 PMCR- 2024/06/28 CRDT- 2024/07/13 01:19 PHST- 2024/05/27 00:00 [received] PHST- 2024/06/18 00:00 [revised] PHST- 2024/06/21 00:00 [accepted] PHST- 2024/07/13 07:42 [medline] PHST- 2024/07/13 07:41 [pubmed] PHST- 2024/07/13 01:19 [entrez] PHST- 2024/06/28 00:00 [pmc-release] AID - s24134203 [pii] AID - sensors-24-04203 [pii] AID - 10.3390/s24134203 [doi] PST - epublish SO - Sensors (Basel). 2024 Jun 28;24(13):4203. doi: 10.3390/s24134203. PMID- 38999907 OWN - NLM STAT- MEDLINE DCOM- 20240715 LR - 20240715 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 13 DP - 2024 Jul 7 TI - Usefulness of Body Fat and Visceral Fat Determined by Bioimpedanciometry versus Body Mass Index and Waist Circumference in Predicting Elevated Values of Different Risk Scales for Non-Alcoholic Fatty Liver Disease. LID - 10.3390/nu16132160 [doi] LID - 2160 AB - BACKGROUND: Obesity constitutes a public health problem worldwide and causes non-alcoholic fatty liver disease (MALFD), the leading cause of liver disease in developed countries, which progresses to liver cirrhosis and liver cancer. MAFLD is associated with obesity and can be evaluated by validated formulas to assess MAFLD risk using different parameters such as the body mass index (BMI) and waist circumference (WC). However, these parameters do not accurately measure body fat. As MAFLD is strongly associated with obesity, we hypothesize that measuring body and visceral fat by electrical bioimpedance is an efficient method to predict the risk of MAFLD. The objective of our work was to demonstrate that electrical bioimpedance is a more efficient method than the BMI or WC to predict an elevated risk of MAFLD. METHODS: A cross-sectional, descriptive study involving 8590 Spanish workers in the Balearic Islands was carried out. The study's sample of employees was drawn from those who underwent occupational medicine examinations between January 2019 and December 2020. Five MAFLD risk scales were determined for evaluating very high levels of body fat and visceral fat. The determination of body and visceral fat was performed using bioimpedanciometry. Student's t-test was employed to ascertain the mean and standard deviation of quantitative data. The chi-square test was used to find prevalences for qualitative variables, while ROC curves were used to define the cut-off points for body and visceral fat. The calculations included the area under the curve (AUC), the cut-off points along with their Youden index, sensitivity, and specificity. Correlation and concordance between the various scales were determined using Pearson's correlation index and Cohen's kappa, respectively. RESULTS: As both total body fat and visceral fat increase, the risk of MAFLD increases with a statistically significant result (p < 0.001), presenting a higher risk in men. The areas under the curve (AUC) of the five scales that assess overweight and obesity to determine the occurrence of high values of the different MAFLD risk scales were very high, most of them exceeding 0.9. These AUC values were higher for visceral and body fat than for the BMI or waist circumference. FLD-high presented the best results in men and women with the AUC at around 0.97, both for visceral fat and total body fat, with a high Youden index in all cases (women body fat = 0.830, visceral fat = 0.892; men body fat = 0.780, visceral fat = 0.881). CONCLUSIONS: In our study, all the overweight and obesity scales show a very good association with the scales assessing the risk of MAFLD. These values are higher for visceral and body fat than for waist circumference and the BMI. Both visceral fat and body fat are better associated than the BMI and waist circumference with MAFLD risk scales. FAU - Gordito Soler, Maria AU - Gordito Soler M AD - Pharmaceutical, 41013 Seville, Seville, Spain. FAU - Lopez-Gonzalez, Angel Arturo AU - Lopez-Gonzalez AA AUID- ORCID: 0000-0002-7439-8117 AD - Investigation Group ADEMA SALUD, University Institute for Research in Health Sciences (IUNICS), 07010 Palma, Balearic Islands, Spain. AD - Faculty of Dentistry, University School ADEMA, 07010 Palma, Balearic Islands, Spain. FAU - Vallejos, Daniela AU - Vallejos D AD - Investigation Group ADEMA SALUD, University Institute for Research in Health Sciences (IUNICS), 07010 Palma, Balearic Islands, Spain. AD - Faculty of Dentistry, University School ADEMA, 07010 Palma, Balearic Islands, Spain. FAU - Martinez-Almoyna Rifa, Emilio AU - Martinez-Almoyna Rifa E AD - Investigation Group ADEMA SALUD, University Institute for Research in Health Sciences (IUNICS), 07010 Palma, Balearic Islands, Spain. AD - Faculty of Dentistry, University School ADEMA, 07010 Palma, Balearic Islands, Spain. FAU - Vicente-Herrero, Maria Teofila AU - Vicente-Herrero MT AD - Investigation Group ADEMA SALUD, University Institute for Research in Health Sciences (IUNICS), 07010 Palma, Balearic Islands, Spain. FAU - Ramirez-Manent, Jose Ignacio AU - Ramirez-Manent JI AUID- ORCID: 0000-0001-6887-4562 AD - Investigation Group ADEMA SALUD, University Institute for Research in Health Sciences (IUNICS), 07010 Palma, Balearic Islands, Spain. AD - Institut d'Investigacio Sanitaria de les Illes Balears (IDISBA), Balearic Islands Health Research Institute Foundation, 07010 Palma, Balearic Islands, Spain. AD - Balearic Islands Health Service, 07010 Palma, Balearic Islands, Spain. AD - Faculty of Medicine, University of the Balearic Islands, 07010 Palma, Balearic Islands, Spain. LA - eng PT - Journal Article DEP - 20240707 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - *Intra-Abdominal Fat/metabolism MH - *Electric Impedance MH - *Non-alcoholic Fatty Liver Disease/diagnosis/pathology MH - *Adipose Tissue/metabolism/pathology MH - Spain MH - Cross-Sectional Studies MH - *Risk Assessment/methods MH - Predictive Value of Tests MH - Humans MH - Male MH - Female MH - Adult MH - Middle Aged MH - Adolescent MH - Young Adult MH - Aged PMC - PMC11243258 OTO - NOTNLM OT - body fat OT - body mass index OT - non-alcoholic fatty liver disease OT - obesity OT - visceral fat OT - waist circumference COIS- The authors declare no conflicts of interest. EDAT- 2024/07/13 07:47 MHDA- 2024/07/13 07:48 PMCR- 2024/07/07 CRDT- 2024/07/13 01:13 PHST- 2024/06/03 00:00 [received] PHST- 2024/06/28 00:00 [revised] PHST- 2024/07/05 00:00 [accepted] PHST- 2024/07/13 07:48 [medline] PHST- 2024/07/13 07:47 [pubmed] PHST- 2024/07/13 01:13 [entrez] PHST- 2024/07/07 00:00 [pmc-release] AID - nu16132160 [pii] AID - nutrients-16-02160 [pii] AID - 10.3390/nu16132160 [doi] PST - epublish SO - Nutrients. 2024 Jul 7;16(13):2160. doi: 10.3390/nu16132160. PMID- 38999875 OWN - NLM STAT- MEDLINE DCOM- 20240713 LR - 20240831 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 13 DP - 2024 Jul 3 TI - Effect of a Low-Glycemic Index Nutritional Intervention on Body Weight and Selected Cardiometabolic Parameters in Children and Adolescents with Excess Body Weight and Dyslipidemia. LID - 10.3390/nu16132127 [doi] LID - 2127 AB - Excess body weight in pediatric patients and the resulting dyslipidemia, if left untreated, are a serious risk factor for cardiovascular disease in young adults. Despite this, there is still no effective and validated nutritional strategy for the treatment of overweight/obesity and comorbid dyslipidemia in children and adolescents. A low-glycemic index (LGI) diet may be recommended, but evidence for its effectiveness in the pediatric population is limited. The aim of this study was to evaluate the effectiveness of nutritional intervention in children and adolescents with excess body weight and dyslipidemia. The study was conducted in patients aged 8-16 with overweight or obesity and lipid disorders (n = 64), of which 40 participants who completed the entire 8-week study were included in the analysis. Patients were randomly selected and allocated to one of the two dietary groups: the LGI diet or the standard therapy (ST) diet. Both diets were based on the principal recommendation of Cardiovascular Health Integrated Lifestyle Diet-2 (CHILD-2). This study showed that both LGI and ST diets were equally beneficial in reducing body weight, body fat, blood pressure, total cholesterol (TC), and triglyceride (TG) levels. The LGI diet, compared to the ST diet, was less effective in reducing blood TG levels but more effective in reducing diastolic blood pressure (DBP). Therefore, the choice of the type of diet in the treatment of children and adolescents with excess body weight and dyslipidemia may be individual. However, it should be based on the recommendation of CHILD-2. Further long-term, larger-scale studies are needed. FAU - Bondyra-Wisniewska, Beata AU - Bondyra-Wisniewska B AUID- ORCID: 0000-0002-2919-4713 AD - Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS), 159C Nowoursynowska St, 02-776 Warsaw, Poland. FAU - Harton, Anna AU - Harton A AUID- ORCID: 0000-0001-5805-6996 AD - Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS), 159C Nowoursynowska St, 02-776 Warsaw, Poland. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20240703 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Triglycerides) SB - IM MH - Humans MH - Adolescent MH - Child MH - Male MH - Female MH - *Dyslipidemias/diet therapy/blood/therapy MH - *Glycemic Index MH - Body Weight MH - Overweight/diet therapy/therapy MH - Blood Pressure MH - Pediatric Obesity/diet therapy/therapy MH - Triglycerides/blood PMC - PMC11243242 OTO - NOTNLM OT - adolescent OT - body mass index OT - child OT - diet OT - diet therapy OT - dyslipidemias OT - glycemic index OT - lipids OT - nutritional intervention OT - obesity COIS- The authors declare no conflicts of interest. EDAT- 2024/07/13 07:47 MHDA- 2024/07/13 07:48 PMCR- 2024/07/03 CRDT- 2024/07/13 01:13 PHST- 2024/06/14 00:00 [received] PHST- 2024/06/29 00:00 [revised] PHST- 2024/07/01 00:00 [accepted] PHST- 2024/07/13 07:48 [medline] PHST- 2024/07/13 07:47 [pubmed] PHST- 2024/07/13 01:13 [entrez] PHST- 2024/07/03 00:00 [pmc-release] AID - nu16132127 [pii] AID - nutrients-16-02127 [pii] AID - 10.3390/nu16132127 [doi] PST - epublish SO - Nutrients. 2024 Jul 3;16(13):2127. doi: 10.3390/nu16132127. PMID- 38999776 OWN - NLM STAT- MEDLINE DCOM- 20240713 LR - 20250211 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 13 DP - 2024 Jun 26 TI - Intermittent Fasting: Socio-Economic Profile of Spanish Citizens Who Practice It and the Influence of This Dietary Pattern on the Health and Lifestyle Habits of the Population. LID - 10.3390/nu16132028 [doi] LID - 2028 AB - Intermittent fasting (IF) is a dietary approach that has gained popularity in recent years. More and more Spanish people are following this eating pattern, which consists of alternating periods of fasting with periods of food intake. Its benefits include improved metabolic and vascular health and weight loss. OBJECTIVES: 1. To study the prevalence of IF among the Spanish population. 2. To explore how demographic factors influence the choice to adopt this dietary approach. METHODS: A descriptive cross-sectional study was conducted on the Spanish population using the NutSo-HH questionnaire, which was constructed, validated, and disseminated by the research team through a non-probabilistic snowball sampling approach, collecting socio-demographic data and nutritional, social and lifestyle habits of the population. RESULTS AND CONCLUSIONS: A valid sample of 22,181 people participated, of whom 4.59% (n = 1018) said they practiced IF. The data show that more middle-aged men than women practice IF. In addition, individuals who follow IF methods are less likely to have no control over their food intake, are less scared to gain weight and have a higher body image, but no differences were found related to unhealthy food and nights out. There were also no significant differences in terms of the level of education, income, size of municipality, or region of residence. In conclusion, a person who practices IF seems to have adopted a healthier lifestyle and social habits. FAU - Sandri, Elena AU - Sandri E AUID- ORCID: 0000-0001-5770-0719 AD - Faculty of Medicine and Health Sciences, Catholic University of Valencia San Vicente Martir, c/Quevedo, 2, 46001 Valencia, Spain. AD - Doctoral School, Catholic University of Valencia San Vicente Martir, c/Quevedo 2, 46001 Valencia, Spain. FAU - Borghesi, Daniele AU - Borghesi D AUID- ORCID: 0000-0002-0979-0585 AD - Master's Degree in Data Science and Business Informatics, University of Pisa, Lungarno Pacinotti 43, 56126 Pisa, Italy. FAU - Cantin Larumbe, Eva AU - Cantin Larumbe E AUID- ORCID: 0009-0009-0016-0227 AD - Degree in Data Science, Polytechnical University of Valencia, Cami de Vera, s/n, 46022 Valencia, Spain. FAU - Cerda Olmedo, German AU - Cerda Olmedo G AUID- ORCID: 0000-0003-4466-4151 AD - Faculty of Medicine and Health Sciences, Catholic University of Valencia San Vicente Martir, c/Quevedo, 2, 46001 Valencia, Spain. FAU - Vega-Bello, Maria Jesus AU - Vega-Bello MJ AD - Faculty of Medicine and Health Sciences, Catholic University of Valencia San Vicente Martir, c/Quevedo, 2, 46001 Valencia, Spain. FAU - Bernalte Marti, Vicente AU - Bernalte Marti V AUID- ORCID: 0000-0002-6419-2238 AD - Predepartmental Nursing Unit, Faculty of Health Sciences, Jaume I University, Avda. Sos Baynat, s/n, 12071 Castellon, Spain. LA - eng PT - Journal Article DEP - 20240626 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Female MH - Spain MH - Middle Aged MH - Cross-Sectional Studies MH - Adult MH - *Life Style MH - *Fasting MH - *Feeding Behavior MH - *Socioeconomic Factors MH - Aged MH - Surveys and Questionnaires MH - Young Adult MH - Diet/statistics & numerical data MH - Adolescent MH - Intermittent Fasting PMC - PMC11243379 OTO - NOTNLM OT - Mediterranean diet OT - Spain OT - healthy lifestyle OT - intermittent fasting OT - survey COIS- None of the authors had any financial, personal or professional conflicts of interest in relation to the results of this study. EDAT- 2024/07/13 07:44 MHDA- 2024/07/13 07:45 PMCR- 2024/06/26 CRDT- 2024/07/13 01:12 PHST- 2024/05/18 00:00 [received] PHST- 2024/06/15 00:00 [revised] PHST- 2024/06/25 00:00 [accepted] PHST- 2024/07/13 07:45 [medline] PHST- 2024/07/13 07:44 [pubmed] PHST- 2024/07/13 01:12 [entrez] PHST- 2024/06/26 00:00 [pmc-release] AID - nu16132028 [pii] AID - nutrients-16-02028 [pii] AID - 10.3390/nu16132028 [doi] PST - epublish SO - Nutrients. 2024 Jun 26;16(13):2028. doi: 10.3390/nu16132028. PMID- 38998830 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240715 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 12 IP - 13 DP - 2024 Jun 28 TI - Evaluating the Validity of International Standards of Height, Weight, and Body Mass Index on Jordanian Children and Adolescents. LID - 10.3390/healthcare12131295 [doi] LID - 1295 AB - BACKGROUND: the variations in a child's overall body shape and figure among different countries are attributable to differences in genetics, environmental factors, and the interaction between these elements. This study aims to evaluate the validity, reliability, and appropriateness of applying international growth standards to Jordanian children and adolescents aged 2-19 years old. METHODS: 65,828 Jordanian children and adolescents (43% males; 57% females) aged 2-19 years old were selected from the Hakeem Program database and various private schools across Jordan. Height-for-age, weight-for-age, and body mass index (BMI)-for-age were analyzed comparatively for Jordanian children and adolescents against international growth standards. The z-score for each record was computed based on international equations. RESULTS: Mean z-scores for height-for-age, weight-for-age, and BMI-for-age for both genders showed significant deviation from international standards across most age intervals. It was found that in most age groups, Jordanian children and adolescents were shorter and lighter than CDC and WHO standards, except for females at ages >/= 16 years, who were heavier with higher BMI-for-age values than CDC standards based on weight-for-age and BMI-for-age equations. Moreover, Jordanian males at ages >/= 12 years had lower BMI-for-age values than CDC standards. CONCLUSIONS: Jordanian children and adolescents showed significant deviations in their measurements from international standards and growth reference values. The development of a population-specific growth chart is highly recommended to enhance the accuracy of evaluating children's and adolescents' wellness. FAU - Al-Qerem, Walid AU - Al-Qerem W AUID- ORCID: 0000-0001-9831-7572 AD - Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan. FAU - Zumot, Ruba AU - Zumot R AD - Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan. FAU - Jarab, Anan AU - Jarab A AUID- ORCID: 0000-0002-0416-506X AD - College of Pharmacy, Al Ain University, Abu Dhabi 112612, United Arab Emirates. AD - AAU Health and Biomedical Research Center, Al Ain University, Abu Dhabi 112612, United Arab Emirates. AD - Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan. FAU - Eberhardt, Judith AU - Eberhardt J AUID- ORCID: 0000-0003-0745-178X AD - Department of Psychology, School of Social Sciences, Humanities and Law, Teesside University, Borough Road, Middlesbrough TS1 3BX, UK. FAU - Alasmari, Fawaz AU - Alasmari F AUID- ORCID: 0000-0003-2382-5892 AD - Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 12372, Saudi Arabia. FAU - Hammad, Alaa AU - Hammad A AUID- ORCID: 0000-0003-3800-1220 AD - Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan. LA - eng GR - 20/09/2022-2023/King Saud University/ PT - Journal Article DEP - 20240628 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC11240996 OTO - NOTNLM OT - BMI-for-age OT - growth standards OT - height-for-age OT - weight-for-age COIS- The authors declare no conflicts of interest. EDAT- 2024/07/13 07:44 MHDA- 2024/07/13 07:45 PMCR- 2024/06/28 CRDT- 2024/07/13 01:07 PHST- 2024/05/23 00:00 [received] PHST- 2024/06/24 00:00 [revised] PHST- 2024/06/26 00:00 [accepted] PHST- 2024/07/13 07:45 [medline] PHST- 2024/07/13 07:44 [pubmed] PHST- 2024/07/13 01:07 [entrez] PHST- 2024/06/28 00:00 [pmc-release] AID - healthcare12131295 [pii] AID - healthcare-12-01295 [pii] AID - 10.3390/healthcare12131295 [doi] PST - epublish SO - Healthcare (Basel). 2024 Jun 28;12(13):1295. doi: 10.3390/healthcare12131295. PMID- 38997723 OWN - NLM STAT- MEDLINE DCOM- 20240713 LR - 20240831 IS - 1757-2215 (Electronic) IS - 1757-2215 (Linking) VI - 17 IP - 1 DP - 2024 Jul 12 TI - The possible short-term of Nigella sativa - L in the management of adolescent polycystic ovarian syndrome: results of a randomized controlled trial. PG - 144 LID - 10.1186/s13048-024-01460-x [doi] LID - 144 AB - BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive age and the most common cause of infertility due to anovulation. PCOS in adolescents is concerning. Nigella sativa is effective in improving gonadotropins and sex hormones. The current study was designed to investigate the effect of Nigella sativa supplementation on PCOS symptoms and their severity in adolescents. METHODS: The current randomized clinical trial was conducted on 114 adolescents with PCOS who were referred to gynecologist offices and clinics in Gonabad, Iran from March 2022 to March 2023. Participants were randomly allocated to the intervention (Nigella sativa 1000 mg/day) and control (10 mg/day medroxyprogesterone from the 14th day of the cycle for 10 nights) groups. The study duration was 16 weeks. Ovarian volume (measured by ultrasound), anthropometric and blood pressure; serum testosterone, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), luteinizing hormone (LH), hirsutism severity (Ferriman-Gallwey score) levels were evaluated before and after the study. RESULTS: Data from 103 participants (control group = 53, intervention group = 50) were analyzed. The mean age of participants was 17.0 (Interquartile range [IQR]:2.0). The mean difference in hirsutism score changes (p < 0.001), right (p = 0.002), and left (p = 0.010) ovarian volume, serum LH (p < 0.001) and testosterone (p = 0.001) were significantly higher in the intervention group compared to the control group. The frequency of oligomenorrhea, menometrorrhagia, and amenorrhea, were significantly reduced after the study in the intervention group compared to the control group (ps < 0.001). CONCLUSIONS: Short-term Nigella sativa supplementation may be effective in reducing ovarian volume and improving hormonal balance, and menstrual irregularities in adolescents with PCOS. Further research and long-term studies are warranted to validate the potential therapeutic effects of Nigella sativa in adolescents with PCOS. IRCT REGISTRATION NUMBER: IRCT20221017056209N1 Registration date: 2022-11-22. CI - (c) 2024. The Author(s). FAU - Mahmoudian, Azamsadat AU - Mahmoudian A AUID- ORCID: 0000-0003-2746-6540 AD - Department of Obstetrics & Gynecology, School of Medicine, Social Determinants of Health Research Center, Gonabad University of Medical Sciences, Gonabad, Iran. FAU - Ashouri, Akram AU - Ashouri A AD - Department of Midwifery, School of Medicine, Social Determinants of Health Research Center, Gonabad University of Medical Sciences, Gonabad, Iran. FAU - Bilandi, Roghaieh Rahmani AU - Bilandi RR AUID- ORCID: 0000-0002-7830-2733 AD - Department of Midwifery, Faculty of Medicine, Reproductive Health and Population Research Center, Gonabad University of Medical Sciences, Gonabad, Iran. FAU - Mohammadzadeh, Fatemeh AU - Mohammadzadeh F AUID- ORCID: 0000-0002-8449-2430 AD - Department of Epidemiology and Biostatistics, School of Health, Gonabad University of Medical Sciences, Gonabad, Iran. FAU - Dashti, Sareh AU - Dashti S AUID- ORCID: 0000-0003-2145-4290 AD - Department of Midwifery, Faculty of Nursing and Midwifery, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran. AD - Department of Public Health, Faculty of Paramedicine, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran. FAU - Bahri, Narjes AU - Bahri N AUID- ORCID: 0000-0002-1877-2573 AD - Department of Midwifery, School of Medicine, Social Determinants of Health Research Center, Gonabad University of Medical Sciences, Gonabad, Iran. nargesbahri@yahoo.com. LA - eng GR - 1195/Gonabad University of Medical Sciences/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20240712 PL - England TA - J Ovarian Res JT - Journal of ovarian research JID - 101474849 SB - IM MH - Humans MH - *Polycystic Ovary Syndrome/drug therapy MH - Female MH - Adolescent MH - *Nigella sativa PMC - PMC11242022 OTO - NOTNLM OT - Adolescent OT - Medroxyprogesterone OT - Nigella sativa OT - Polycystic ovary syndrome COIS- The authors declare no competing interests. EDAT- 2024/07/13 07:48 MHDA- 2024/07/13 07:49 PMCR- 2024/07/12 CRDT- 2024/07/12 23:36 PHST- 2024/04/05 00:00 [received] PHST- 2024/06/18 00:00 [accepted] PHST- 2024/07/13 07:49 [medline] PHST- 2024/07/13 07:48 [pubmed] PHST- 2024/07/12 23:36 [entrez] PHST- 2024/07/12 00:00 [pmc-release] AID - 10.1186/s13048-024-01460-x [pii] AID - 1460 [pii] AID - 10.1186/s13048-024-01460-x [doi] PST - epublish SO - J Ovarian Res. 2024 Jul 12;17(1):144. doi: 10.1186/s13048-024-01460-x. PMID- 38996100 OWN - NLM STAT- MEDLINE DCOM- 20240712 LR - 20240926 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 103 IP - 28 DP - 2024 Jul 12 TI - Prevalence, and types of overuse injuries in gym centers: A cross-sectional study in Saudi Arabia. PG - e38830 LID - 10.1097/MD.0000000000038830 [doi] LID - e38830 AB - Physical activity has numerous health benefits, enhancing overall wellbeing. However, it can also lead to injuries, impeding exercise capacity and hindering work. Limited knowledge exists about the prevalence of overuse gym injuries and whether they vary across different gym activities. This study aims to estimate sport injuries at fitness centers in Saudi Arabia, comparing injuries between various activities and session durations. This is a cross-sectional, questionnaire-based study surveyed regular gym-goers in Saudi Arabia with overuse injuries. The online survey, distributed through social media apps, collected data using a validated Google form questionnaire. Questioanire consists of 3 parts. First part of the questionnaire included demographic characteristics of participants. Second part contains characteristics related to gym as gym session's duration, frequency of attending gym per week, sport types, type of injuries and site of injuries. Third part contains Oslo Sports Trauma Research Centre (OSTRC) Overuse injury questionnaire that included 4 questions about difficulties in participation, reduction of training, affection of performance and symptoms. Study included 1012 participants, majority male (76.2%), with age range of 18 to 50 years, and significant proportion falling between 26 and 30 years (52.6%). Majority of participants were from Central Province (42.9%). Gym sessions typically lasted 1 to 2 hours (68.3%), and most common attendance frequency was 4 days/week (39.6%). Common injury sites were shoulder (25.2%), knee (20.2%), and lower back (17.7%). Bodybuilding (50.6%), running (45.8%), and weightlifting/powerlifting (45.1%) were predominant sports. Strain/muscle rupture/tear (35.70%) and muscle cramps/spasm (19.3%) were commonest injury types. Longer gym sessions (>2 hours) were associated with higher prevalence of strain/muscle rupture/tear, dislocation, and subluxation (P < .001). Shorter sessions (<1 hour) had higher prevalence of muscle cramps/spasm and contusion/hematoma/bruise (P < .001). Gym sessions lasting 1 to 2 hours had high prevalence in tendinosis/tendinopathy. Strain/muscle rupture/tear was significantly higher in bodybuilding, weightlifting/powerlifting, swimming, cycling, and running. Tendinosis/tendinopathy was higher in crossfit. (OSTRC) Overuse injury questionnaire revealed decreased participation, training volume, performance, and increased pain with longer gym sessions. In conclusion, gym-related injuries are common, with bodybuilding and running being prevalent activities. Preventative measures should be taken, and individuals are advised to undergo a physical and medical examination before engaging in physical activity at fitness centers. CI - Copyright (c) 2024 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Hetaimish, Bandar AU - Hetaimish B AUID- ORCID: 0000-0001-9905-855 AD - Department of Orthopedic Surgery, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia. FAU - Ahmed, Hassan AU - Ahmed H AUID- ORCID: 0000-0002-0171-1694 AD - Pediatric Department, King Salman Medical City-Maternity and Children, Medina, Saudi Arabia. FAU - Otayn, Abdullah AU - Otayn A AD - Emergency Department, Alhasa Health Cluster, Alhasa, Saudi Arabia. FAU - Alzahrani, Ahmed M AU - Alzahrani AM AD - College of Medicine, University of Jeddah, Jeddah, Saudi Arabia. FAU - Almasoudi, Eid AU - Almasoudi E AD - College of Medicine, University of Jeddah, Jeddah, Saudi Arabia. FAU - Elaiw, Mohammed AU - Elaiw M AD - College of Medicine, University of Jeddah, Jeddah, Saudi Arabia. FAU - Alzwaihri, Abubakr S AU - Alzwaihri AS AD - College of Medicine, University of Jeddah, Jeddah, Saudi Arabia. FAU - Samargandi, Ramy AU - Samargandi R AD - Department of Orthopedic Surgery, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia. AD - Orthopedic Surgery Department, Centre Hospitalier Regional Universitaire (CHRU) de Tours, Tours, France. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Cross-Sectional Studies MH - Saudi Arabia/epidemiology MH - Adult MH - *Cumulative Trauma Disorders/epidemiology MH - Male MH - Prevalence MH - Female MH - Middle Aged MH - Young Adult MH - Adolescent MH - *Athletic Injuries/epidemiology MH - Surveys and Questionnaires MH - Fitness Centers/statistics & numerical data MH - Exercise PMC - PMC11245209 COIS- The authors have no funding and conflicts of interest to disclose. EDAT- 2024/07/12 18:42 MHDA- 2024/07/12 18:43 PMCR- 2024/07/12 CRDT- 2024/07/12 15:03 PHST- 2024/07/12 18:43 [medline] PHST- 2024/07/12 18:42 [pubmed] PHST- 2024/07/12 15:03 [entrez] PHST- 2024/07/12 00:00 [pmc-release] AID - 00005792-202407120-00013 [pii] AID - MD-D-24-02222 [pii] AID - 10.1097/MD.0000000000038830 [doi] PST - ppublish SO - Medicine (Baltimore). 2024 Jul 12;103(28):e38830. doi: 10.1097/MD.0000000000038830. PMID- 38995874 OWN - NLM STAT- MEDLINE DCOM- 20250425 LR - 20250912 IS - 2153-2176 (Electronic) IS - 2153-2168 (Print) IS - 2153-2168 (Linking) VI - 21 IP - 1 DP - 2025 Jan TI - High BMI z-Scores from Different Growth References Are Not Comparable: An Example from a Weight Management Trial with an Anti-Obesity Medication in Pubertal Adolescents with Obesity. PG - 22-29 LID - 10.1089/chi.2024.0248 [doi] AB - Background: The BMI z-score is a standardized measure of weight status and weight change in children and adolescents. BMI z-scores from various growth references are often considered comparable, and differences among them are underappreciated. Methods: This study reanalyzed data from a weight management clinical study of liraglutide in pubertal adolescents with obesity using growth references from CDC 2000, CDC Extended, World Health Organization (WHO), and International Obesity Task Force. Results: BMI z-score treatment differences varied 2-fold from -0.13 (CDC 2000) to -0.26 (WHO) overall and varied almost 4-fold from -0.05 (CDC 2000) to -0.19 (WHO) among adolescents with high baseline BMI z-score. Conclusions: Depending upon the growth reference used, BMI z-score endpoints can produce highly variable treatment estimates and alter interpretations of clinical meaningfulness. BMI z-scores cited without the associated growth reference cannot be accurately interpreted. FAU - Hales, Craig M AU - Hales CM AUID- ORCID: 0000-0002-2355-1177 AD - Centers for Disease Control and Prevention, Hyattsville, MD, USA. FAU - Ogden, Cynthia L AU - Ogden CL AD - Centers for Disease Control and Prevention, Hyattsville, MD, USA. FAU - Freedman, David S AU - Freedman DS AUID- ORCID: 0000-0001-8014-0289 AD - Centers for Disease Control and Prevention, Atlanta, GA, USA. FAU - Sahu, Kushal AU - Sahu K AD - Novo Nordisk Global Business Services, Bengaluru, Karnataka, India. FAU - Hale, Paula M AU - Hale PM AD - Novo Nordisk Inc., Plainsboro, NJ, USA. FAU - Mamadi, Rashmi K AU - Mamadi RK AD - Novo Nordisk Global Business Services, Bengaluru, Karnataka, India. FAU - Kelly, Aaron S AU - Kelly AS AD - Department of Pediatrics and Center for Pediatric Obesity Medicine, University of Minnesota Medical School, Minneapolis, MN, USA. LA - eng GR - CC999999/ImCDC/Intramural CDC HHS/United States PT - Comparative Study PT - Journal Article DEP - 20240712 PL - United States TA - Child Obes JT - Childhood obesity (Print) JID - 101542497 RN - 839I73S42A (Liraglutide) RN - 0 (Glucagon-Like Peptide-1 Receptor Agonists) SB - IM MH - Secondary Data Analysis MH - *Body Mass Index MH - Reference Values MH - Randomized Controlled Trials as Topic MH - Clinical Trials, Phase III as Topic MH - Humans MH - Male MH - Female MH - Adolescent MH - Multicenter Studies as Topic MH - Reproducibility of Results MH - *Pediatric Obesity/drug therapy/physiopathology MH - *Liraglutide/therapeutic use MH - *Glucagon-Like Peptide-1 Receptor Agonists/therapeutic use MH - Reference Standards MH - *Growth Charts MH - Treatment Outcome MH - *Outcome Assessment, Health Care/methods/standards PMC - PMC12422332 MID - NIHMS2100179 OTO - NOTNLM OT - BMI OT - childhood obesity OT - clinical endpoints OT - clinical trials OT - growth chart OT - growth reference COIS- Author Disclosure Statement C.M.H., C.L.O., and D.F. report no conflicts of interest. K.S., P.M.H., and R.K.M. are employees of and hold shares in Novo Nordisk. A.S.K. engages in unpaid consulting and educational activities for Boehringer Ingelheim, Eli Lilly, Novo Nordisk, and Vivus and receives donated drug/placebo from Vivus and donated drug from Novo Nordisk for National Institute of Diabetes and Digestive and Kidney Diseases-funded clinical trials. EDAT- 2024/07/12 18:42 MHDA- 2025/01/15 12:24 PMCR- 2025/09/10 CRDT- 2024/07/12 13:22 PHST- 2025/01/15 12:24 [medline] PHST- 2024/07/12 18:42 [pubmed] PHST- 2024/07/12 13:22 [entrez] PHST- 2025/09/10 00:00 [pmc-release] AID - 10.1089/chi.2024.0248 [doi] PST - ppublish SO - Child Obes. 2025 Jan;21(1):22-29. doi: 10.1089/chi.2024.0248. Epub 2024 Jul 12. PMID- 38994809 OWN - NLM STAT- MEDLINE DCOM- 20241117 LR - 20241117 IS - 1550-9613 (Electronic) IS - 0278-4297 (Linking) VI - 43 IP - 10 DP - 2024 Oct TI - Peripartum Prediction of Fetal Weight in Gravidas With Obesity. PG - 1903-1910 LID - 10.1002/jum.16523 [doi] AB - OBJECTIVES: Estimated fetal weight (EFW) is an important metric at delivery as neonates with abnormal birthweight and their mothers are at higher risk of birth complications. Data regarding optimal EFW assessment in gravidas with obesity is inconsistent, and with the increasing incidence of obesity, clarification of this question is crucial. We aimed to compare accuracy of ultrasound (US)-derived EFW and clinical assessments of EFW in predicting neonatal birthweight among gravidas with obesity. METHODS: This prospective cohort study enrolled gravidas with obesity and a singleton pregnancy admitted for delivery at term. EFW was determined using either US biometry or clinical assessment (Leopold's maneuvers, Johnson's formula, and Insler's formula) at time of admission. Our primary outcome was accurate EFW, defined as EFW within 500 g of birthweight. Secondary outcomes included ability to predict small-for-gestational age (SGA) and large-for-gestational age (LGA) birthweights. These outcomes were compared between all EFW methods. RESULTS: A total of 250 gravidas with a median body mass index of 36.4 kg/m(2) were enrolled. Admission US outperformed Leopold's maneuvers in obtaining accurate EFW (81.6% versus 74.5%, P = .03). When comparing all methods, Johnson's and Insler's formulae performed the worst, accurately predicting EFW in only 27.4% and 14.3% of cases, respectively. Likewise, US-derived EFW outperformed Leopold's maneuvers and fundal height in the prediction of SGA and LGA neonates. CONCLUSIONS: US is more accurate than clinical assessment of EFW in gravidas with obesity both for estimation of actual birthweight and prediction of abnormal birthweight. Universal late third-trimester or peripartum US for EFW should be considered in gravidas with obesity. CI - (c) 2024 American Institute of Ultrasound in Medicine. FAU - Bligard, Katherine H AU - Bligard KH AUID- ORCID: 0000-0002-6029-1052 AD - Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine and Ultrasound, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA. FAU - Kelly, Jeannie C AU - Kelly JC AD - Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine and Ultrasound, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA. FAU - Frolova, Antonina I AU - Frolova AI AD - Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine and Ultrasound, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA. FAU - Odibo, Anthony O AU - Odibo AO AD - Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine and Ultrasound, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA. FAU - Raghuraman, Nandini AU - Raghuraman N AD - Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine and Ultrasound, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA. LA - eng GR - Foundation of Barnes-Jewish Hospital/ PT - Journal Article DEP - 20240712 PL - England TA - J Ultrasound Med JT - Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine JID - 8211547 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Fetal Weight MH - Prospective Studies MH - *Ultrasonography, Prenatal/methods MH - Adult MH - *Obesity/complications MH - Cohort Studies MH - Peripartum Period MH - Predictive Value of Tests MH - Pregnancy Complications/diagnostic imaging MH - Birth Weight MH - Infant, Newborn MH - Reproducibility of Results OTO - NOTNLM OT - LGA OT - Leopold's maneuvers OT - SGA OT - birthweight OT - fundal height OT - ultrasound EDAT- 2024/07/12 12:43 MHDA- 2024/11/17 06:21 CRDT- 2024/07/12 07:43 PHST- 2024/05/24 00:00 [revised] PHST- 2024/03/06 00:00 [received] PHST- 2024/06/29 00:00 [accepted] PHST- 2024/11/17 06:21 [medline] PHST- 2024/07/12 12:43 [pubmed] PHST- 2024/07/12 07:43 [entrez] AID - 10.1002/jum.16523 [doi] PST - ppublish SO - J Ultrasound Med. 2024 Oct;43(10):1903-1910. doi: 10.1002/jum.16523. Epub 2024 Jul 12. PMID- 38993823 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240714 IS - 2223-8956 (Electronic) IS - 1016-3190 (Print) IS - 1016-3190 (Linking) VI - 36 IP - 3 DP - 2024 Jul-Sep TI - The beneficial effects of conservative treatment with biofeedback and electrostimulation on pelvic floor disorders. PG - 291-297 LID - 10.4103/tcmj.tcmj_174_23 [doi] AB - OBJECTIVES: Pelvic floor disorders (PFDs) such as stress urinary incontinence (SUI) and pelvic organ prolapse (POP) can be managed through conservative treatments, such as conservative management involving biofeedback (BF) and electrostimulation. This study aimed to investigate the therapeutic effects of conservative treatments on PFDs. MATERIALS AND METHODS: A retrospective cohort study was conducted. Women with PFD who underwent 1-3 months of BF and electrostimulation between January 1, 2020, and January 31, 2021, were included in the study. BF treatment was administered using three sensors to monitor pelvic floor muscle activity, providing patients with immediate feedback and guidance on muscle exercises. One session lasted for 5-10 min. Electrostimulation treatment utilized a specially made pelvic belt with electrode sheets to stimulate and contract pelvic floor muscles passively. One session lasted for 15 min. Six therapies in 1 month were prescribed. Pre- and post-treatment Pelvic Floor Distress Inventory (PFDI-20) scores, including POP distress inventory 6 (POPDI-6), colorectal-anal distress inventory (CRAD-8), and urinary distress inventory 6 (UDI-6) scores, were compared. Subgroup analysis by age, menopause, body mass index (BMI), and child delivery mode was performed. RESULTS: The study included 51 women with PFDs (SUI, POP, frequency or urgency or nocturia, and pain) treated with BF and electrostimulation, with a mean age of 49.94 +/- 13.63 years. Sixteen patients (37.1%) were menopausal, with a mean menopause age of 50 +/- 5.20 years. Twenty-six patients (68.4%) had a history of normal vaginal delivery. The mean PFDI-20 scores before and after treatment were 32.67 (standard deviation [SD] 10.05) and 25.99 (SD 9.61), respectively (P < 0.001). This decrease in scores reflected an improvement in subjective perceptions of symptoms and quality of life. The POPDI-6, CRAD-8, and UDI-6 scores significantly decreased after treatment. Subgroup analysis of scores change regarding age, menopause, BMI, and child delivery mode was not statistically significant. CONCLUSION: The study demonstrated the effectiveness of BF and electrostimulation for treating women with PFDs. The findings contributed to the understanding of treatment duration, patient characteristics, and the potential benefits of a multimodal approach. Moreover, the study's diverse participant population and the use of validated outcome measures enhance the generalizability and scientific rigor of the findings. CI - Copyright: (c) 2023 Tzu Chi Medical Journal. FAU - Chen, Mei-Chen AU - Chen MC AD - Department of Medicine, College of Medicine, Tzu Chi University, Hualien, Taiwan. AD - Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien, Taiwan. FAU - Lai, Pei-Hsuan AU - Lai PH AD - Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien, Taiwan. FAU - Ding, Dah-Ching AU - Ding DC AD - Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien, Taiwan. AD - Institute of Medical Science, College of Medicine, Tzu Chi University, Hualien, Taiwan. LA - eng PT - Journal Article DEP - 20230922 PL - India TA - Tzu Chi Med J JT - Tzu chi medical journal JID - 101770275 PMC - PMC11236079 OTO - NOTNLM OT - Biofeedback OT - Electrostimulation OT - Pelvic organ prolapse OT - Pelvic pain OT - Stress urinary incontinence COIS- Dr.Dah-Ching Ding, an editorial board member at Tzu Chi Medical Journal, had no role in the peer review process of or decision to publish this article. The other authors declared no conflicts of interest in writing this paper. EDAT- 2024/07/12 06:42 MHDA- 2024/07/12 06:43 PMCR- 2023/09/22 CRDT- 2024/07/12 04:43 PHST- 2023/07/13 00:00 [received] PHST- 2023/08/07 00:00 [revised] PHST- 2023/08/24 00:00 [accepted] PHST- 2024/07/12 06:43 [medline] PHST- 2024/07/12 06:42 [pubmed] PHST- 2024/07/12 04:43 [entrez] PHST- 2023/09/22 00:00 [pmc-release] AID - TCMJ-36-291 [pii] AID - 10.4103/tcmj.tcmj_174_23 [doi] PST - epublish SO - Tzu Chi Med J. 2023 Sep 22;36(3):291-297. doi: 10.4103/tcmj.tcmj_174_23. eCollection 2024 Jul-Sep. PMID- 38992716 OWN - NLM STAT- MEDLINE DCOM- 20240712 LR - 20240714 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 23 IP - 1 DP - 2024 Jul 11 TI - Brief instruments for measuring nutrition literacy - the Nutrition Health Literacy Scale and the Self-Perceived Food Literacy Scale Short Form. PG - 73 LID - 10.1186/s12937-024-00971-z [doi] LID - 73 AB - BACKGROUND: A healthy diet is a critical factor in maintaining long-term health. In addition to a health-promoting food environment, the nutrition health literacy (NHL) and food literacy (FL) of the population are important in this context. This paper describes the development and validation of two short instruments to measure the nutrition literacy of the population, used in the Austrian Nutrition Literacy Survey 2021. METHODS: An instrument to measure NHL (Nutrition Health Literacy Scale; NHLS) has been adapted and further developed. To measure FL, the Self-perceived Food Literacy Scale by Poelman et al. has been modified and shortened (SPFL-SF). Validation of the instruments was based on data from a web survey conducted in Austria in 2021 with almost 3,000 participants aged 18 years and older. Exploratory and confirmatory factor analyses were performed to assess the factorial validity/dimensionality of the instruments. Additionally, internal consistency was assessed using Cronbach's alpha, ordinal alpha, and McDonald's omega. RESULTS: Both instruments demonstrate excellent data-model fit. The NHLS also shows excellent internal consistency (alpha = 0.91), while the SPFL-SF displays a sufficient internal consistency for all (alpha between 0.70 and 0.89) but one sub-dimension (resisting temptation alpha = 0.61). Furthermore, the distribution of the items indicates that the measures are understandable and suitable, as evidenced by the absence of missing values in the sample. In addition, the items of both instruments differ in their level of difficulty or agreement. CONCLUSIONS: The NHLS and SPFL-SF are reliable and valid instruments for measuring NHL and FL in the general adult population. The brief instruments measuring the different aspects of nutrition literacy can be easily used in nutritional or evaluation studies. Further work is required to investigate other aspects of validity. CI - (c) 2024. The Author(s). FAU - Griebler, Robert AU - Griebler R AD - Austrian National Public Health Institute, Stubenring 6, Vienna, 1010, Austria. FAU - Schutze, Denise AU - Schutze D AD - Austrian National Public Health Institute, Stubenring 6, Vienna, 1010, Austria. denise.schuetze@goeg.at. FAU - Link, Thomas AU - Link T AD - Austrian National Public Health Institute, Stubenring 6, Vienna, 1010, Austria. FAU - Schindler, Karin AU - Schindler K AD - Department of Internal Medicine III, Div. Endocrinology and Metabolism, Medical University Vienna, Wahringer Gurtel 18-20, Vienna, 1090, Austria. LA - eng PT - Journal Article PT - Validation Study DEP - 20240711 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 SB - IM MH - Humans MH - *Health Literacy/methods MH - Female MH - Male MH - Adult MH - Reproducibility of Results MH - Austria MH - Middle Aged MH - Surveys and Questionnaires/standards MH - Aged MH - Psychometrics/methods/instrumentation MH - Young Adult MH - Adolescent MH - Self Concept MH - Health Knowledge, Attitudes, Practice MH - Nutrition Surveys/methods MH - Nutritional Sciences/education PMC - PMC11238471 OTO - NOTNLM OT - Food literacy OT - Health literacy OT - Measure OT - Nutrition health literacy OT - Nutrition literacy OT - Validity COIS- The authors declare no competing interests. EDAT- 2024/07/12 00:41 MHDA- 2024/07/12 06:42 PMCR- 2024/07/11 CRDT- 2024/07/11 23:49 PHST- 2024/02/21 00:00 [received] PHST- 2024/06/26 00:00 [accepted] PHST- 2024/07/12 06:42 [medline] PHST- 2024/07/12 00:41 [pubmed] PHST- 2024/07/11 23:49 [entrez] PHST- 2024/07/11 00:00 [pmc-release] AID - 10.1186/s12937-024-00971-z [pii] AID - 971 [pii] AID - 10.1186/s12937-024-00971-z [doi] PST - epublish SO - Nutr J. 2024 Jul 11;23(1):73. doi: 10.1186/s12937-024-00971-z. PMID- 38989126 OWN - NLM STAT- MEDLINE DCOM- 20240711 LR - 20260610 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 12 DP - 2024 TI - Methodologies for the collection of parameters to estimate dust/soil ingestion for young children. PG - 1357346 LID - 10.3389/fpubh.2024.1357346 [doi] LID - 1357346 AB - BACKGROUND: Heavy metals, pesticides and a host of contaminants found in dust and soil pose a health risk to young children through ingestion. Dust/soil ingestion rates for young children can be estimated using micro-level activity time series (MLATS) as model inputs. MLATS allow for the generation of frequency and duration of children's contact activities, along with sequential contact patterns. Models using MLATS consider contact types, and transfer dynamics to assign mechanisms of contact and appropriate exposure factors for cumulative estimates of ingestion rates. OBJECTIVE: The objective of this study is to describe field implementation, data needs, advanced field collection, laboratory methodologies, and challenges for integrating into and updating a previously validated physical-stochastic MLATS-based model framework called the Child-Specific Aggregate Cumulative Human Exposure and Dose (CACHED) model. The manuscript focuses on describing the methods implemented in the current study. METHODS: This current multidisciplinary study (Dust Ingestion childRen sTudy [DIRT]) was implemented across three US regions: Tucson, Arizona; Miami, Florida and Greensboro, North Carolina. Four hundred and fifty participants were recruited between August 2021 to June 2023 to complete a 4-part household survey, of which 100 also participated in a field study. DISCUSSION: The field study focused on videotaping children's natural play using advanced unattended 360( degrees ) cameras mounted for participants' tracking and ultimately conversion to MLATS. Additionally, children's hand rinses were collected before and after recording, along with indoor dust and outdoor soil, followed by advanced mass analysis. The gathered data will be used to quantify dust/soil ingestion by region, sociodemographic variables, age groups (from 6 months to 6 years), and other variables for indoor/outdoor settings within an adapted version of the CACHED model framework. SIGNIFICANCE: New innovative approaches for the estimation of dust/soil ingestion rates can potentially improve modeling and quantification of children's risks to contaminants from dust exposure. CI - Copyright (c) 2024 Ferguson, Adelabu, Solo-Gabriele, Obeng-Gyasi, Fayad-Martinez, Gidley, Honan, Ogunseye and Beamer. FAU - Ferguson, Alesia AU - Ferguson A AD - Department of Built Environment, North Carolina Agricultural and Technical State University, Greensboro, NC, United States. FAU - Adelabu, Foluke AU - Adelabu F AD - Department of Built Environment, North Carolina Agricultural and Technical State University, Greensboro, NC, United States. FAU - Solo-Gabriele, Helena AU - Solo-Gabriele H AD - Department of Chemical, Environmental, and Materials Engineering, University of Miami, Coral Gables, FL, United States. FAU - Obeng-Gyasi, Emmanuel AU - Obeng-Gyasi E AD - Department of Built Environment, North Carolina Agricultural and Technical State University, Greensboro, NC, United States. FAU - Fayad-Martinez, Cristina AU - Fayad-Martinez C AD - Department of Chemical, Environmental, and Materials Engineering, University of Miami, Coral Gables, FL, United States. FAU - Gidley, Maribeth AU - Gidley M AD - Department of Chemical, Environmental, and Materials Engineering, University of Miami, Coral Gables, FL, United States. FAU - Honan, Jenna AU - Honan J AD - Department of Community, Environmental and Policy, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, United States. FAU - Ogunseye, Olusola O AU - Ogunseye OO AD - Department of Community, Environmental and Policy, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, United States. FAU - Beamer, Paloma I AU - Beamer PI AD - Department of Community, Environmental and Policy, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, United States. LA - eng GR - P30 ES006694/ES/NIEHS NIH HHS/United States PT - Journal Article DEP - 20240626 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - 0 (Dust) RN - 0 (Soil) SB - IM MH - Humans MH - *Dust/analysis MH - Child, Preschool MH - *Soil MH - *Environmental Exposure/analysis MH - Female MH - Male MH - Infant MH - Environmental Monitoring/methods MH - North Carolina MH - Arizona MH - Child MH - Eating MH - Florida PMC - PMC11234889 OTO - NOTNLM OT - MLATS OT - children's activity patterns OT - dust ingestion OT - exposure OT - soil ingestion COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2024/07/11 06:42 MHDA- 2024/07/11 06:43 PMCR- 2024/06/26 CRDT- 2024/07/11 04:35 PHST- 2023/12/17 00:00 [received] PHST- 2024/06/04 00:00 [accepted] PHST- 2024/07/11 06:43 [medline] PHST- 2024/07/11 06:42 [pubmed] PHST- 2024/07/11 04:35 [entrez] PHST- 2024/06/26 00:00 [pmc-release] AID - 10.3389/fpubh.2024.1357346 [doi] PST - epublish SO - Front Public Health. 2024 Jun 26;12:1357346. doi: 10.3389/fpubh.2024.1357346. eCollection 2024. PMID- 38985818 OWN - NLM STAT- MEDLINE DCOM- 20240710 LR - 20260921 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 7 DP - 2024 TI - Estimates of functional muscle strength from a novel progressive lateral step-up test are feasible, reliable, and related to physical activity in children with cerebral palsy. PG - e0306529 LID - 10.1371/journal.pone.0306529 [doi] LID - e0306529 AB - OBJECTIVE: To determine if estimates of functional muscle strength from a novel progressive lateral-step-up test (LSUT) are feasible, reliable, and related to physical activity in children with cerebral palsy (CP). DESIGN: Cross-sectional; test-retest reliability Subjects/Patients: Children with CP and typically developing control children (n = 45/group). METHODS: An LSUT with 10, 15, and 20 cm step heights was completed. It was repeated 4 weeks later in 20 children with CP. A composite score of LSUT was calculated based on the step height and number of repetitions completed. Physical activity was assessed using monitors worn on the ankle and hip. RESULTS: Only 4 (13%) of the children with CP were unable to complete a lateral step-up repetition without assistance. All children were able to complete at least 1 repetition with assistance, though more than twice as many children with CP required assistance at 15 and 20 cm step heights than at the 10 cm step height (p < 0.01). Children with CP had 59 to 63% lower LSUT performance, 37% lower physical activity assessed at the ankle, and 22% lower physical activity assessed at the hip than controls (all p < 0.01). The intra-class correlation coefficient ranged from 0.91 to 0.96 for LSUT performance at the different step heights and was 0.97 for the composite score. All LSUT performance measures were positively related to ankle physical activity in children with CP (r range = 0.43 to 0.47, all p < 0.01). Only performance at 20 cm and the composite score were positively related to hip physical activity (r = 0.33 and 0.31, respectively, both p < 0.05). The relationship between the LSUT performance and physical activity at both the ankle and hip increased when age and sex were statistically controlled (model r range = 0.55 to 0.60, all p < 0.001). CONCLUSION: Estimates of functional muscle strength from a novel progressive LSUT are feasible, reliable, and positively related to physical activity in children with CP. CI - Copyright: (c) 2024 Batson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Batson, Trevor AU - Batson T AD - Department of Kinesiology, University of Georgia, Athens, GA, United States of America. FAU - Whitten, Sydni V W AU - Whitten SVW AD - Department of Kinesiology, University of Georgia, Athens, GA, United States of America. FAU - Singh, Harshvardhan AU - Singh H AD - Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL, United States of America. FAU - Zhang, Chuan AU - Zhang C AD - School of Physical Education and Sports, Central China Normal University, Wuhan, China. FAU - Colquitt, Gavin AU - Colquitt G AUID- ORCID: 0000-0003-3460-1085 AD - Appalachian Institute for Health and Wellness, Beaver College of Health Sciences, Appalachian State University, Boone, NC, United States of America. FAU - Modlesky, Christopher M AU - Modlesky CM AUID- ORCID: 0000-0003-2654-6311 AD - Department of Kinesiology, University of Georgia, Athens, GA, United States of America. LA - eng GR - R01 HD090126/HD/NICHD NIH HHS/United States GR - R15 HD071397/HD/NICHD NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20240710 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology MH - Child MH - Female MH - Male MH - *Muscle Strength/physiology MH - *Exercise/physiology MH - Cross-Sectional Studies MH - Exercise Test/methods MH - Adolescent MH - Reproducibility of Results PMC - PMC11236174 COIS- The authors have declared that no competing interests exist. EDAT- 2024/07/10 18:42 MHDA- 2024/07/10 18:43 PMCR- 2024/07/10 CRDT- 2024/07/10 13:45 PHST- 2023/09/17 00:00 [received] PHST- 2024/06/19 00:00 [accepted] PHST- 2024/07/10 18:43 [medline] PHST- 2024/07/10 18:42 [pubmed] PHST- 2024/07/10 13:45 [entrez] PHST- 2024/07/10 00:00 [pmc-release] AID - PONE-D-23-23848 [pii] AID - 10.1371/journal.pone.0306529 [doi] PST - epublish SO - PLoS One. 2024 Jul 10;19(7):e0306529. doi: 10.1371/journal.pone.0306529. eCollection 2024. PMID- 38985816 OWN - NLM STAT- MEDLINE DCOM- 20250422 LR - 20250514 IS - 1476-8305 (Electronic) IS - 1028-415X (Linking) VI - 28 IP - 3 DP - 2025 Mar TI - The association of the Prime Diet Quality Score (PDQS) with depression and anxiety symptoms: the Isfahan functional disorders (ISFUN) cohort study. PG - 360-369 LID - 10.1080/1028415X.2024.2372190 [doi] AB - BACKGROUND: Due to scarce epidemiologic data regarding the Prime Diet Quality Score (PDQS) and mental health disorders, this study aimed to investigate the association of PDQS with depression and anxiety symptoms in Iranian adults. METHODS: This cross-sectional analysis was performed using the baseline data collected for the Isfahan functional disorders (ISFUN) cohort study. ISFUN was established in 2017 and enrolled apparently healthy adults, aged 18-65 years in Isfahan, Iran. Information on usual dietary intakes was collected using a validated Dish-based, 106-item food frequency questionnaire. The severity of depression and anxiety was assessed using a validated Iranian version of the Hospital Anxiety and Depression Scale. RESULTS: A total number of1892 participants were enrolled in the present study. In total, 54.50% of subjects were female. In the fully adjusted model, participants with PDQS lower than median compared with those with PDQS higher than median had higher risk of depression (OR = 1.62; 95% CI: 1.11, 2.37) and anxiety (OR: 1.57; 95% CI: 1.08, 2.27). In stratified analysis by sex, males with PDQS lower than median compared with those with PDQS higher than median had greater risk for depressive (OR: 1.57) and anxiety symptoms (OR = 1.52). However, in females, no significant association was found between PDQS and odds of depression, and anxiety in the fully adjusted model. CONCLUSION: We found evidence indicating a significant inverse association between PDQS and depression and anxiety symptoms among Iranian adults. Further studies, in particular with prospective design, are required to confirm these findings. FAU - Haghighatdoost, Fahimeh AU - Haghighatdoost F AD - Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Feizi, Awat AU - Feizi A AD - Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Hajihashemi, Parisa AU - Hajihashemi P AUID- ORCID: 0000-0001-8375-1333 AD - Isfahan Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Shahoon, Hassan AU - Shahoon H AD - Isfahan Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Ani, Alireza AU - Ani A AD - Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Roohafza, Hamidreza AU - Roohafza H AD - Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Adibi, Peyman AU - Adibi P AD - Isfahan Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. LA - eng PT - Journal Article DEP - 20240710 PL - England TA - Nutr Neurosci JT - Nutritional neuroscience JID - 100892202 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Iran/epidemiology MH - *Anxiety/epidemiology MH - Middle Aged MH - *Depression/epidemiology MH - Cross-Sectional Studies MH - Young Adult MH - Aged MH - Cohort Studies MH - Adolescent MH - *Diet OTO - NOTNLM OT - Prime diet quality score OT - anxiety OT - depression OT - diet quality OT - mental health disorders EDAT- 2024/07/10 18:42 MHDA- 2025/02/15 15:11 CRDT- 2024/07/10 13:45 PHST- 2025/02/15 15:11 [medline] PHST- 2024/07/10 18:42 [pubmed] PHST- 2024/07/10 13:45 [entrez] AID - 10.1080/1028415X.2024.2372190 [doi] PST - ppublish SO - Nutr Neurosci. 2025 Mar;28(3):360-369. doi: 10.1080/1028415X.2024.2372190. Epub 2024 Jul 10. PMID- 38985813 OWN - NLM STAT- MEDLINE DCOM- 20240710 LR - 20260828 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 7 DP - 2024 TI - Psychological distress and its associated factors among people with specific chronic conditions (diabetes and/or hypertension) in the Sidama region of southern Ethiopia: A cross-sectional study. PG - e0303196 LID - 10.1371/journal.pone.0303196 [doi] LID - e0303196 AB - BACKGROUND: The majority of people with long-term, non-communicable medical conditions experience significant psychological anguish. Poor mental health or psychological distress influences low lifestyle decisions that result in obesity, inactivity, and cigarette use as well as poor health literacy and limited access to health promotion activities. OBJECTIVES: The study's purpose was to measure the prevalence of psychological distress and it's predictors in patients with chronic non-communicable diseases who were being treated in selected hospitals in the Sidama region of southern Ethiopia in 2022. METHODOLOGY: Institutional based cross-sectional study was carried out using a sample of 844 patients receiving medication for either high blood pressure or diabetes mellitus or both between May1 and August 31, 2022. To gauge psychiatric distress, the Amharic translation and Ethiopian validation of the Kessler 6 scale (K-6) was employed. The analysis was done using binary logistic regression and an odds ratio with the corresponding 95% confidence interval was estimated to measure the strength of the association. P value <0.05 was considered to declare the significance. RESULT: Patients with diabetic mellitus, hypertension or both had a 49.6% prevalence of psychological distress at selected Sidama hospitals. Age, drug side effects, history medical complications following diabetic mellitus/hypertension, and body mass index of the patient were all significantly linked with psychological distress (P<0.05). CONCLUSION: According to the results of this study, psychological distress is far more prevalent than it was in past studies in Ethiopia and other African countries. To lessen the problem, all stakeholders must cooperate, but health agencies, policymakers, and NGOs particularly need to put in extra effort. The study also showed a significant association between body mass index, patient age, drug side effects, and history of medical complications following diabetic mellitus /hypertension. CI - Copyright: (c) 2024 Borie et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Borie, Yacob Abraham AU - Borie YA AUID- ORCID: 0000-0001-8329-5964 AD - Department of Psychiatry, College of Medicine and Health Science, Hawassa University, Hawassa, Ethiopia. FAU - Tamiso, Alemu AU - Tamiso A AD - School of Public Health, College of Medicine and Health Science, Hawassa University, Ethiopia. FAU - Gutema, Keneni AU - Gutema K AD - School of Public Health, College of Medicine and Health Science, Hawassa University, Ethiopia. FAU - Jisso, Meskerem AU - Jisso M AD - School of Public Health, College of Medicine and Health Science, Hawassa University, Ethiopia. FAU - Deribe, Bedilu AU - Deribe B AD - School of Public Health, College of Medicine and Health Science, Hawassa University, Ethiopia. AD - School of Nursing, College of Medicine and Health Science, Hawassa University, Hawassa, Ethiopia. FAU - Fikre, Rekiku AU - Fikre R AD - Department of Midwifery, College of Medicine and Health Science, Hawassa University, Hawassa, Ethiopia. FAU - Defar, Semira AU - Defar S AD - Department of Midwifery, College of Medicine and Health Science, Hawassa University, Hawassa, Ethiopia. FAU - Ayalew, Mohammed AU - Ayalew M AD - Department of Psychiatry, College of Medicine and Health Science, Hawassa University, Hawassa, Ethiopia. FAU - Abera, Wondwossen AU - Abera W AD - School of Medical Laboratory, College of Medicine and Health Science, Hawassa University, Hawassa, Ethiopia. LA - eng PT - Journal Article DEP - 20240710 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Ethiopia/epidemiology MH - Male MH - Female MH - *Hypertension/epidemiology/psychology MH - Middle Aged MH - Cross-Sectional Studies MH - Adult MH - *Diabetes Mellitus/epidemiology/psychology MH - *Psychological Distress MH - Prevalence MH - Chronic Disease/epidemiology MH - Aged MH - Stress, Psychological/epidemiology MH - Young Adult MH - Adolescent PMC - PMC11236106 COIS- The authors have declared that no competing interests exist. EDAT- 2024/07/10 18:42 MHDA- 2024/07/10 18:43 PMCR- 2024/07/10 CRDT- 2024/07/10 13:44 PHST- 2023/04/05 00:00 [received] PHST- 2024/04/17 00:00 [accepted] PHST- 2024/07/10 18:43 [medline] PHST- 2024/07/10 18:42 [pubmed] PHST- 2024/07/10 13:44 [entrez] PHST- 2024/07/10 00:00 [pmc-release] AID - PONE-D-23-10171 [pii] AID - 10.1371/journal.pone.0303196 [doi] PST - epublish SO - PLoS One. 2024 Jul 10;19(7):e0303196. doi: 10.1371/journal.pone.0303196. eCollection 2024. PMID- 38984009 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240711 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 16 IP - 6 DP - 2024 Jun TI - Criterion-Related Validity of the Sugar-Sweetened Beverage (SSB) Questionnaire Among Children and Adolescents in Malaysia. PG - e61984 LID - 10.7759/cureus.61984 [doi] LID - e61984 AB - Sugar-sweetened beverages (SSBs) are a major source of dietary sugar, and their consumption is on the rise among children and adolescents. Excessive sugar intake is a significant contributor to overweight, obesity, and non-communicable diseases (NCDs). The consumption of SSBs, particularly that of children and adolescents, has been of interest as of late, as they are implicated in affecting body weight status. Thus, the goal of this study was to determine the predictive criterion-related validity of the SSB questionnaire that was administered to children and adolescents to assess their SSB and non-SSB intake. A nationwide cross-sectional study involving 5211 respondents aged 7-17 years old and their parents was conducted. The self-administered Malay questionnaire was distributed to collect information on socioeconomic background, the frequency of eating out at restaurants or other food premises, the availability of SSBs at home, and SSB consumption patterns of children and adolescents within a week. The predictive criterion-related validity was determined by using six hypotheses that can differentiate between two independent sample means of SSB consumption based on age, gender, locality, monthly household income, frequency of eating out at restaurants or other food premises, and availability of SSBs at home. The independent samples t-test and one-way ANOVA were used to conduct the validation process. Five out of six hypotheses were accepted. Significant mean differences were observed between sociodemographic factors, such as age (t=-10.56, p<0.001), localities (t=-5.37, p<0.001), monthly household income (F=26.83, p<0.001), and SSB consumption. Behavioural factors, including eating out at restaurants or other food premises (t=9.93, p<0.001) and environmental factors such as the availability of SSBs at home (F=136.24, p<0.001) also showed a significant difference with SSB consumption. The SSB questionnaire demonstrated the ability to differentiate between groups. Thus, this SSB questionnaire appears to be valid to measure the SSB consumption of children and adolescents. CI - Copyright (c) 2024, Bakeri et al. FAU - Bakeri, Nur Arina AU - Bakeri NA AD - Department of Nutrition, Universiti Putra Malaysia, Serdang, MYS. FAU - Amirullah, Nur Amalina AU - Amirullah NA AD - Department of Nutrition, Universiti Putra Malaysia, Serdang, MYS. FAU - Sulaiman, Norhasmah AU - Sulaiman N AD - Department of Nutrition, Universiti Putra Malaysia, Serdang, MYS. FAU - Gan, Wan Ying AU - Gan WY AD - Department of Nutrition, Universiti Putra Malaysia, Serdang, MYS. FAU - Loh, Su Peng AU - Loh SP AD - Department of Nutrition, Universiti Putra Malaysia, Serdang, MYS. FAU - Ahmad Fuzi, Salma Faeza AU - Ahmad Fuzi SF AD - Department of Nutrition, Universiti Putra Malaysia, Serdang, MYS. FAU - Shafie, Siti Raihanah AU - Shafie SR AD - Department of Nutrition, Universiti Putra Malaysia, Serdang, MYS. FAU - Ibrahim, Nazli Suhardi AU - Ibrahim NS AD - Nutrition Division, Ministry of Health Malaysia, Putrajaya, MYS. FAU - Mohamad, Fatimah Zurina AU - Mohamad FZ AD - Nutrition Division, Ministry of Health Malaysia, Putrajaya, MYS. FAU - Selamat, Rusidah AU - Selamat R AD - Nutrition Division, Ministry of Health Malaysia, Putrajaya, MYS. LA - eng PT - Journal Article DEP - 20240609 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC11232472 OTO - NOTNLM OT - adolescents OT - children OT - criterion-related validity OT - obesity OT - overweight OT - sugar-sweetened beverages COIS- Human subjects: Consent was obtained or waived by all participants in this study. Ethics Committee for Research Involving Human Subjects at Universiti Putra Malaysia (JKEUPM) issued approval JKEUPM-2022-029. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: This work was supported by "The Impact and Effectiveness of Sugar-Sweetened Beverages (SSBs) Taxation in Malaysia" research grant (vot. number: 6300312) funded by the United Nations International Children's Emergency Fund (UNICEF) with support from the Ministry of Health, Malaysia. Financial relationships: Norhasmah Sulaiman declare(s) a grant from United Nations International Children's Emergency Fund (UNICEF). Prof. Dr. Norhasmah Sulaiman is the principal investigator for the grant from UNICEF. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2024/07/10 06:41 MHDA- 2024/07/10 06:42 PMCR- 2024/06/09 CRDT- 2024/07/10 04:47 PHST- 2024/06/08 00:00 [accepted] PHST- 2024/07/10 06:42 [medline] PHST- 2024/07/10 06:41 [pubmed] PHST- 2024/07/10 04:47 [entrez] PHST- 2024/06/09 00:00 [pmc-release] AID - 10.7759/cureus.61984 [doi] PST - epublish SO - Cureus. 2024 Jun 9;16(6):e61984. doi: 10.7759/cureus.61984. eCollection 2024 Jun. PMID- 38983951 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250612 IS - 2590-1133 (Electronic) IS - 2590-1133 (Linking) VI - 8 DP - 2024 Dec TI - Reliability of a short diet and vitamin supplement questionnaire for retrospective collection of maternal nutrient intake. PG - 100150 LID - 10.1016/j.gloepi.2024.100150 [doi] LID - 100150 AB - BACKGROUND: Gestational nutrition can protect against adverse neurodevelopmental outcomes. OBJECTIVES: We developed a short tool for collecting maternal nutritional intake during pregnancy to facilitate research in this area and compared its retrospective use to prospectively-collected food frequency questionnaires (FFQ). METHODS: Maternal nutritional intake was retrospectively assessed using three versions (full interview, full self-administered online, and shortened interview) of the Early Life Exposure Assessment Tool (ELEAT) among participants of the MARBLES pregnancy cohort study of younger siblings of autistic children. Retrospective responses were compared with responses to supplement questions and the validated 2005 Block FFQ prospectively collected in MARBLES during pregnancies 2-7 years prior. ELEAT nutrient values were calculated using reported food intake frequencies and nutrient values from the USDA nutrient database. Correlations between retrospectively- and prospectively-reported intake were evaluated using Kappa coefficients, Youden's J, and Spearman Rank Correlation Coefficients (r(s)). RESULTS: MARBLES FFQ dietary intakes were compared among 54 women who completed the ELEAT full form including 12 online, and among 23 who completed the ELEAT short form. Correlations across most foods were fair to moderate. Most ELEAT quantified nutrient values were moderately correlated (r(s) = 0.3-0.6) with those on the Block FFQ. Supplement questions in both MARBLES and the ELEAT were completed by 114 women. Kappas were moderate for whether or not supplements were taken, but modest for timing. Correlations varied by version and child diagnosis or concerns, and were higher when mothers completed the ELEAT when their child was 4 years old or younger. CONCLUSIONS: With recall up to several years, ELEAT dietary and supplement module responses were modestly to moderately reliable and produced nutrient values moderately correlated with prospectively-collected measures. The ELEAT dietary and vitamin supplements modules can be used to rank participants in terms of intake of several nutrients relevant for neurodevelopment. CI - (c) 2024 The Authors. Published by Elsevier Inc. FAU - Schmidt, Rebecca J AU - Schmidt RJ AD - Department of Public Health Sciences, University of California Davis School of Medicine, Davis, CA, United States of America. AD - MIND Institute, University of California Davis School of Medicine, Sacramento, CA, United States of America. FAU - Goodrich, Amanda J AU - Goodrich AJ AD - Department of Public Health Sciences, University of California Davis School of Medicine, Davis, CA, United States of America. FAU - Granillo, Lauren AU - Granillo L AD - Graduate Group in Epidemiology, University of California Davis, Davis, CA, United States of America. FAU - Huang, Yunru AU - Huang Y AD - Graduate Group in Epidemiology, University of California Davis, Davis, CA, United States of America. FAU - Krakowiak, Paula AU - Krakowiak P AD - Department of Public Health Sciences, University of California Davis School of Medicine, Davis, CA, United States of America. FAU - Widaman, Adrianne AU - Widaman A AD - Graduate Group in Nutritional Biology, University of California Davis, Davis, CA, United States of America. FAU - Dienes, J Erin AU - Dienes JE AD - Department of Statistics, University of California Davis, Davis, CA, United States of America. FAU - Bennett, Deborah H AU - Bennett DH AD - Department of Public Health Sciences, University of California Davis School of Medicine, Davis, CA, United States of America. FAU - Walker, Cheryl K AU - Walker CK AD - MIND Institute, University of California Davis School of Medicine, Sacramento, CA, United States of America. AD - Department of Obstetrics and Gynecology, University of California Davis School of Medicine, Davis, CA, United States of America. FAU - Tancredi, Daniel J AU - Tancredi DJ AD - Department of Pediatrics, University of California Davis School of Medicine, Sacramento, CA, United States of America. LA - eng GR - R01 ES020392/ES/NIEHS NIH HHS/United States GR - R24 ES028533/ES/NIEHS NIH HHS/United States GR - U24 ES028533/ES/NIEHS NIH HHS/United States PT - Journal Article DEP - 20240614 PL - United States TA - Glob Epidemiol JT - Global epidemiology JID - 101759263 PMC - PMC11231718 OTO - NOTNLM OT - Autism/autistic disorder OT - Nutrients/diet/vitamins OT - Pregnancy/pregnant women OT - Reliability OT - Surveys and questionnaires COIS- The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: This project was supported by funding from Autism Speaks, Inc. Dr. Schmidt received funding for travel reimbursement for invited talks from: Obstetrics, Placenta, Epigenetics and Neurodevelopment) in Autism (OPEN Autism) at the Centre for Advanced Research and Excellence in Autism and Developmental Disorders, St. John's Research Institute (Mar 2023) and the Organization of Teratology Information Specialists (OTIS, June 2023). Dr. Schmidt has received funding for consultation services for Beasley Allen Law Firm and Linus Biotechnology, Inc. Dr. Bennett has received funding for consultation services for Linus Biotechnology, Inc. No other authors declare potential competing interests. EDAT- 2024/07/10 06:41 MHDA- 2024/07/10 06:42 PMCR- 2024/06/14 CRDT- 2024/07/10 04:46 PHST- 2023/07/31 00:00 [received] PHST- 2024/05/29 00:00 [revised] PHST- 2024/06/12 00:00 [accepted] PHST- 2024/07/10 06:42 [medline] PHST- 2024/07/10 06:41 [pubmed] PHST- 2024/07/10 04:46 [entrez] PHST- 2024/06/14 00:00 [pmc-release] AID - S2590-1133(24)00016-6 [pii] AID - 100150 [pii] AID - 10.1016/j.gloepi.2024.100150 [doi] PST - epublish SO - Glob Epidemiol. 2024 Jun 14;8:100150. doi: 10.1016/j.gloepi.2024.100150. eCollection 2024 Dec. PMID- 38982871 OWN - NLM STAT- MEDLINE DCOM- 20240710 LR - 20240710 IS - 1468-3148 (Electronic) IS - 1360-2322 (Linking) VI - 37 IP - 5 DP - 2024 Sep TI - Measurement of basic psychological needs for physical activity participation for college students with intellectual disabilities: A validation study. PG - e13246 LID - 10.1111/jar.13246 [doi] AB - BACKGROUND: Measurement instruments to understand self-determined motivation towards physical activity among college students with intellectual disabilities are needed to develop programs to support physical and psychological health and well-being. The purpose of the current study was to validate a modified questionnaire measuring basic psychological needs towards physical activity among college students with intellectual disabilities. METHODS: A total of 108 college students with intellectual disabilities completed the modified questionnaire. Validity and reliability of the questionnaire was examined. RESULTS: Confirmatory factor analysis demonstrated a six-factor model had good model fit. Cronbach's alpha values showed acceptable reliability evidence of the instrument as a whole, although some alpha values in subdomains of the instrument were below acceptable values. CONCLUSION: The modified questionnaire was found to have acceptable validity evidence. Further studies are needed with refinement of answer options and the addition of more questions to increase reliability. CI - (c) 2024 The Author(s). Journal of Applied Research in Intellectual Disabilities published by John Wiley & Sons Ltd. FAU - Sur, Myung Ha AU - Sur MH AUID- ORCID: 0000-0003-3432-4620 AD - Department of Kinesiology, University of Wisconsin - Whitewater, Whitewater, Wisconsin, USA. FAU - Shapiro, Deborah R AU - Shapiro DR AUID- ORCID: 0000-0002-5933-2638 AD - Department of Kinesiology and Health, Georgia State University, Atlanta, Georgia, USA. FAU - Li, Hongli AU - Li H AUID- ORCID: 0000-0002-1039-7270 AD - Department of Educational Policy Studies, Georgia State University, Atlanta, Georgia, USA. LA - eng PT - Journal Article PT - Validation Study PL - England TA - J Appl Res Intellect Disabil JT - Journal of applied research in intellectual disabilities : JARID JID - 9613616 SB - IM MH - Humans MH - *Intellectual Disability/psychology MH - Male MH - Female MH - Young Adult MH - *Students/psychology MH - Adult MH - Reproducibility of Results MH - *Exercise MH - Universities MH - Psychometrics/standards/instrumentation MH - Adolescent MH - Surveys and Questionnaires MH - Motivation OTO - NOTNLM OT - autonomy OT - competence OT - need frustration OT - need satisfaction OT - relatedness OT - self-determination theory EDAT- 2024/07/10 06:42 MHDA- 2024/07/10 06:43 CRDT- 2024/07/10 03:32 PHST- 2024/03/20 00:00 [revised] PHST- 2022/12/14 00:00 [received] PHST- 2024/04/29 00:00 [accepted] PHST- 2024/07/10 06:43 [medline] PHST- 2024/07/10 06:42 [pubmed] PHST- 2024/07/10 03:32 [entrez] AID - 10.1111/jar.13246 [doi] PST - ppublish SO - J Appl Res Intellect Disabil. 2024 Sep;37(5):e13246. doi: 10.1111/jar.13246. PMID- 38982172 OWN - NLM STAT- MEDLINE DCOM- 20240709 LR - 20240730 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Jul 9 TI - Association between composite dietary antioxidant and bone mineral density in children and adolescents aged 8-19 years: findings from NHANES. PG - 15849 LID - 10.1038/s41598-024-66859-4 [doi] LID - 15849 AB - Dietary antioxidants may have beneficial effects on bone health, but it remains uncertain in children and adolescents. This study investigates the association of composite dietary antioxidant index (CDAI) with bone mineral density (BMD) in children and adolescents aged 8-19 years from the National Health and Nutrition Examination Survey (NHANES) 2007-2010. The study assessed the relationship between CDAI and BMD in 2994 individuals aged 8-19 years (average age 13.48 +/- 3.32 years) from the NHANES 2007-2010. Multivariate linear regression analyses were utilized to detect the association between CDAI and total spine, femur neck, and total femur BMD, adjusting for confounders including age, race/ethnicity, sex, poverty income ratio (PIR), body mass index (BMI), serum phosphorus and calcium. Stratified analyses and interaction tests were performed to examine the stability of the results. The weighted characteristics showed that subjects in the fourth CDAI quartile were more likely to be older, men, and Non-Hispanic White. They have higher values of serum total calcium and phosphorus. After adjusting all confounders, CDAI was positively associated with the total spine (beta = 0.0031 95% CI 0.0021-0.0040), total femur (beta = 0.0039 95% CI 0.0028-0.0049), and femur neck BMD (beta = 0.0031 95% CI 0.0021-0.0040) in children and adolescents. Furthermore, we found no interaction effects between different race/ethnicity, age, and sex groups. Our findings suggest that dietary intake of multiple antioxidants was positively associated with BMD in children and adolescents. These findings provide valuable evidence for improving bone health in the early stages of life. However, more prospective studies are required to validate our findings and their causal relationship. CI - (c) 2024. The Author(s). FAU - Cui, Aiyong AU - Cui A AD - Department of Orthopaedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an, 710000, China. FAU - Yan, Juan AU - Yan J AD - Department of Medical Services Section, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shen'zhen, 518107, China. FAU - Zeng, Yuan AU - Zeng Y AD - Department of Orthopaedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an, 710000, China. FAU - Shi, Baoqiang AU - Shi B AD - Department of Orthopaedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an, 710000, China. FAU - Cheng, Long AU - Cheng L AD - Department of Orthopaedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an, 710000, China. FAU - Deng, Hongli AU - Deng H AD - Department of Orthopaedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an, 710000, China. 15619525534@163.com. FAU - Wei, Xing AU - Wei X AD - Department of Orthopaedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an, 710000, China. 92871360@163.com. FAU - Zhuang, Yan AU - Zhuang Y AD - Department of Orthopaedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an, 710000, China. zhuangyan2512@163.com. LA - eng PT - Journal Article DEP - 20240709 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Antioxidants) SB - IM MH - Humans MH - *Bone Density MH - Adolescent MH - Child MH - Female MH - Male MH - *Antioxidants/metabolism MH - *Nutrition Surveys MH - Young Adult MH - Diet MH - Femur Neck PMC - PMC11233598 OTO - NOTNLM OT - Adolescence OT - Bone mineral density OT - Children OT - Composite dietary antioxidant index COIS- The authors declare no competing interests. EDAT- 2024/07/10 00:42 MHDA- 2024/07/10 00:43 PMCR- 2024/07/09 CRDT- 2024/07/09 23:36 PHST- 2023/11/03 00:00 [received] PHST- 2024/07/04 00:00 [accepted] PHST- 2024/07/10 00:43 [medline] PHST- 2024/07/10 00:42 [pubmed] PHST- 2024/07/09 23:36 [entrez] PHST- 2024/07/09 00:00 [pmc-release] AID - 10.1038/s41598-024-66859-4 [pii] AID - 66859 [pii] AID - 10.1038/s41598-024-66859-4 [doi] PST - epublish SO - Sci Rep. 2024 Jul 9;14(1):15849. doi: 10.1038/s41598-024-66859-4. PMID- 38980984 OWN - NLM STAT- MEDLINE DCOM- 20241004 LR - 20241006 IS - 2470-9239 (Electronic) IS - 2470-9239 (Linking) VI - 9 IP - 5 DP - 2024 Oct TI - Epileptic seizure forecasting with wearable-based nocturnal sleep features. PG - 1793-1805 LID - 10.1002/epi4.13008 [doi] AB - OBJECTIVE: Non-invasive biomarkers have recently shown promise for seizure forecasting in people with epilepsy. In this work, we developed a seizure-day forecasting algorithm based on nocturnal sleep features acquired using a smart shirt. METHODS: Seventy-eight individuals with epilepsy admitted to the Centre hospitalier de l'Universite de Montreal epilepsy monitoring unit wore the Hexoskin biometric smart shirt during their stay. The shirt continuously measures electrocardiography, respiratory, and accelerometry activity. Ten sleep features, including sleep efficiency, sleep latency, sleep duration, time spent in non-rapid eye movement sleep (NREM) and rapid eye movement sleep (REM), wakefulness after sleep onset, average heart and breathing rates, high-frequency heart rate variability, and the number of position changes, were automatically computed using the Hexoskin sleep algorithm. Each night's features were then normalized using a reference night for each patient. A support vector machine classifier was trained for pseudo-prospective seizure-day forecasting, with forecasting horizons of 16- and 24-h to include both diurnal and nocturnal seizures (24-h) or diurnal seizures only (16-h). The algorithm's performance was assessed using a nested leave-one-patient-out cross-validation approach. RESULTS: Improvement over chance (IoC) performances were achieved for 48.7% and 40% of patients with the 16- and 24-h forecasting horizons, respectively. For patients with IoC performances, the proposed algorithm reached mean IoC, sensitivity and time in warning of 34.3%, 86.0%, and 51.7%, respectively for the 16-h horizon, and 34.2%, 64.4% and 30.2%, respectively, for the 24-h horizon. SIGNIFICANCE: Smart shirt-based nocturnal sleep analysis holds promise as a non-invasive approach for seizure-day forecasting in a subset of people with epilepsy. Further investigations, particularly in a residential setting with long-term recordings, could pave the way for the development of innovative and practical seizure forecasting devices. PLAIN LANGUAGE SUMMARY: Seizure forecasting with wearable devices may improve the quality of life of people living with epilepsy who experience unpredictable, recurrent seizures. In this study, we have developed a seizure forecasting algorithm using sleep characteristics obtained from a smart shirt worn at night by a large number of hospitalized patients with epilepsy (78). A daily seizure forecast was generated following each night using machine learning methods. Our results show that around half of people with epilepsy may benefit from such an approach. CI - (c) 2024 The Author(s). Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy. FAU - Ding, Tian Yue AU - Ding TY AUID- ORCID: 0009-0008-7657-0946 AD - Centre de Recherche du Centre hospitalier de l'Universite de Montreal (CRCHUM), Montreal, Quebec, Canada. FAU - Gagliano, Laura AU - Gagliano L AUID- ORCID: 0000-0003-2049-3714 AD - Centre de Recherche du Centre hospitalier de l'Universite de Montreal (CRCHUM), Montreal, Quebec, Canada. FAU - Jahani, Amirhossein AU - Jahani A AD - Centre de Recherche du Centre hospitalier de l'Universite de Montreal (CRCHUM), Montreal, Quebec, Canada. FAU - Toffa, Denahin H AU - Toffa DH AD - Centre de Recherche du Centre hospitalier de l'Universite de Montreal (CRCHUM), Montreal, Quebec, Canada. FAU - Nguyen, Dang K AU - Nguyen DK AD - Centre de Recherche du Centre hospitalier de l'Universite de Montreal (CRCHUM), Montreal, Quebec, Canada. AD - Department of Neuroscience, Universite de Montreal, Montreal, Quebec, Canada. FAU - Bou Assi, Elie AU - Bou Assi E AUID- ORCID: 0000-0001-8248-2565 AD - Centre de Recherche du Centre hospitalier de l'Universite de Montreal (CRCHUM), Montreal, Quebec, Canada. AD - Department of Neuroscience, Universite de Montreal, Montreal, Quebec, Canada. LA - eng GR - 76138/Institut TransMedTech/ GR - 51678/CAPMC/CIHR/Canada GR - 51493/Canada Research Chairs/ GR - 51481/Natural Sciences and Engineering Research Council of Canada/ GR - 76066/Institut de Valorisation des Donnees/ GR - 51678/CAPMC/CIHR/Canada PT - Journal Article DEP - 20240709 PL - United States TA - Epilepsia Open JT - Epilepsia open JID - 101692036 SB - IM MH - Humans MH - Male MH - Female MH - *Wearable Electronic Devices MH - Adult MH - *Seizures MH - *Epilepsy MH - Middle Aged MH - *Sleep/physiology MH - Algorithms MH - Young Adult MH - Forecasting MH - Support Vector Machine MH - Accelerometry/instrumentation MH - Electrocardiography MH - Polysomnography MH - Adolescent MH - Aged PMC - PMC11450616 OTO - NOTNLM OT - epilepsy OT - forecasting OT - machine learning OT - sleep analysis OT - wearable COIS- None of the authors has any conflict of interest to disclose. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. EDAT- 2024/07/09 18:43 MHDA- 2024/10/04 12:43 PMCR- 2024/07/09 CRDT- 2024/07/09 14:24 PHST- 2024/06/15 00:00 [revised] PHST- 2023/12/04 00:00 [received] PHST- 2024/06/23 00:00 [accepted] PHST- 2024/10/04 12:43 [medline] PHST- 2024/07/09 18:43 [pubmed] PHST- 2024/07/09 14:24 [entrez] PHST- 2024/07/09 00:00 [pmc-release] AID - EPI413008 [pii] AID - 10.1002/epi4.13008 [doi] PST - ppublish SO - Epilepsia Open. 2024 Oct;9(5):1793-1805. doi: 10.1002/epi4.13008. Epub 2024 Jul 9. PMID- 38980218 OWN - NLM STAT- MEDLINE DCOM- 20241002 LR - 20241021 IS - 1538-005X (Electronic) IS - 0898-5669 (Linking) VI - 36 IP - 4 DP - 2024 Oct 1 TI - Effectiveness of Therapeutic Exercise for Children Undergoing Treatment for Cancer: A Systematic Review. PG - 422-438 LID - 10.1097/PEP.0000000000001122 [doi] AB - PURPOSE: To evaluate the effectiveness of therapeutic physical exercise (TPE) interventions on the physical functioning, psychosocial well-being, and quality of life (QoL) of children undergoing treatment for cancer. METHOD: Systematic review: databases were searched in April 2023. Selection criteria: children (<18 years old) undergoing treatment for cancer or a malignant neoplasm, randomized controlled trial design, utilization of TPE, and including physical and psychosocial outcomes. Internal validity was measured with Physiotherapy Evidence Database scale. RESULTS: Seven randomized controlled trials were included. Most studies showed that strength, fatigue, and QoL improved after the intervention. Cardiorespiratory capacity through 6-minute walk test and physical activity levels were better in the experimental groups. No changes were noted in other variables. CONCLUSIONS: This review supports the importance of a TPE program during cancer treatment, with the aim of maintaining physical capacities and counteracting physical inactivity. CI - Copyright (c) 2024 Academy of Pediatric Physical Therapy of the American Physical Therapy Association. FAU - Linero-Bocanegra, Miriam AU - Linero-Bocanegra M AD - Grupo de Investigacion Clinimetria F-14, Instituto de Investigacion Biomedica de Malaga y Plataforma en Nanomedicina (IBIMA Plataforma BIONAND), Malaga, Spain (Mss Linero-Bocanegra, Garcia-Conejo, and Ramirez-Perez, and Drs Cuesta-Vargas and Trinidad-Fernandez); Departamento de Fisioterapia, Universidad de Malaga, Malaga, Spain (Mss Garcia-Conejo and Ramirez-Perez and Drs Cuesta-Vargas and Trinidad-Fernandez). FAU - Garcia-Conejo, Celia AU - Garcia-Conejo C FAU - Ramirez-Perez, Laura AU - Ramirez-Perez L FAU - Cuesta-Vargas, Antonio Ignacio AU - Cuesta-Vargas AI FAU - Trinidad-Fernandez, Manuel AU - Trinidad-Fernandez M LA - eng PT - Journal Article PT - Systematic Review DEP - 20241001 PL - United States TA - Pediatr Phys Ther JT - Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association JID - 8912748 SB - IM MH - Humans MH - *Neoplasms/rehabilitation/therapy MH - Child MH - *Exercise Therapy/methods MH - *Quality of Life MH - Randomized Controlled Trials as Topic MH - Adolescent COIS- The authors declare no conflicts of interest. EDAT- 2024/07/09 12:43 MHDA- 2024/10/02 12:42 CRDT- 2024/07/09 10:24 PHST- 2024/10/02 12:42 [medline] PHST- 2024/07/09 12:43 [pubmed] PHST- 2024/07/09 10:24 [entrez] AID - 00001577-202410000-00005 [pii] AID - 10.1097/PEP.0000000000001122 [doi] PST - ppublish SO - Pediatr Phys Ther. 2024 Oct 1;36(4):422-438. doi: 10.1097/PEP.0000000000001122. Epub 2024 Oct 1. PMID- 38979754 OWN - NLM STAT- MEDLINE DCOM- 20241125 LR - 20250114 IS - 1573-2665 (Electronic) IS - 0141-8955 (Print) IS - 0141-8955 (Linking) VI - 47 IP - 6 DP - 2024 Nov TI - The PompeQoL questionnaire: Development and validation of a new measure for children and adolescents with Pompe disease. PG - 1348-1362 LID - 10.1002/jimd.12777 [doi] AB - Genetic disorders pose great challenges for affected individuals and their families, as they must cope with the irreversible nature of the disease and a life-long dependence on medical assistance and treatment. Children and adolescents dealing with Pompe disease (PD) often struggle to keep up with their peers in physical activities. To gain valuable insights into their subjective experiences and better understand their perception and coping related to daily challenges linked to their condition and treatment, the use of standardized questionnaires is crucial. This study introduces the novel PompeQoL 1.0 questionnaire for children and adolescents with PD, designed for comprehensive assessment of both disease-specific FDH and HRQoL through self- and proxy reports. Content validity was ensured through patients' and parents' involvement at the initial stages of development and in subsequent cognitive debriefing process. Participants found the questionnaire easy to understand, answerable, relevant, and comprehensive. Adjustments based on feedback from patients and their parents improved its utility as a patient- and observer-reported outcome measure. After careful item examination, 52 items were selected, demonstrating moderate to excellent test-retest reliability for most scales and initial evidence for satisfactory construct validity. The PompeQoL questionnaire stands as a valuable screening instrument for both clinical and research purposes. Future research should prioritize additional revisions and larger validation studies, focusing on testing the questionnaire in clinical practice and trials. Nevertheless, the PompeQoL 1.0 stands out as the first standardized measure providing insights into disease-specific FDH and HRQoL among children and adolescents with various forms of PD. CI - (c) 2024 The Author(s). Journal of Inherited Metabolic Disease published by John Wiley & Sons Ltd on behalf of SSIEM. FAU - Truninger, Moritz Ilan AU - Truninger MI AUID- ORCID: 0000-0001-6724-5019 AD - Division of Metabolism, Children's Research Centre, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland. AD - Department of Psychosomatics and Psychiatry, University Children's Hospital Zurich, Zurich, Switzerland. AD - Division of Child and Adolescent Health Psychology, Institute of Psychology, University of Zurich, Zurich, Switzerland. FAU - Werner, Helene AU - Werner H AUID- ORCID: 0000-0002-7081-7695 AD - Division of Metabolism, Children's Research Centre, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland. AD - Department of Psychosomatics and Psychiatry, University Children's Hospital Zurich, Zurich, Switzerland. AD - Division of Child and Adolescent Health Psychology, Institute of Psychology, University of Zurich, Zurich, Switzerland. FAU - Landolt, Markus Andreas AU - Landolt MA AUID- ORCID: 0000-0003-0760-5558 AD - Department of Psychosomatics and Psychiatry, University Children's Hospital Zurich, Zurich, Switzerland. AD - Division of Child and Adolescent Health Psychology, Institute of Psychology, University of Zurich, Zurich, Switzerland. FAU - Hahn, Andreas AU - Hahn A AD - Department of Child Neurology, Justus-Liebig-University Giessen, Giessen, Germany. FAU - Hennermann, Julia B AU - Hennermann JB AD - Villa Metabolica, Center for Pediatric and Adolescent Medicine, University Medical Center Mainz, Mainz, Germany. FAU - Lagler, Florian B AU - Lagler FB AD - Institute for Inherited Metabolic Diseases and Department of Pediatrics, Paracelsus Medical University Salzburg, Salzburg, Austria. FAU - Moslinger, Dorothea AU - Moslinger D AD - Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria. FAU - Pfrimmer, Charlotte AU - Pfrimmer C AD - Department of Child Neurology, Justus-Liebig-University Giessen, Giessen, Germany. FAU - Rohrbach, Marianne AU - Rohrbach M AD - Division of Metabolism, Children's Research Centre, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland. FAU - Huemer, Martina AU - Huemer M AUID- ORCID: 0000-0002-0590-678X AD - Division of Metabolism, Children's Research Centre, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland. AD - Department of Paediatrics, LKH Bregenz, Bregenz, Austria. AD - Competence Area Healthcare and Nursing, Vorarlberg University of Applied Sciences, Dornbirn, Austria. LA - eng GR - Sanofi/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20240709 PL - United States TA - J Inherit Metab Dis JT - Journal of inherited metabolic disease JID - 7910918 SB - IM MH - Humans MH - *Glycogen Storage Disease Type II/diagnosis MH - Adolescent MH - *Quality of Life MH - Surveys and Questionnaires MH - Child MH - Male MH - Female MH - Reproducibility of Results MH - Psychometrics MH - Parents/psychology PMC - PMC11586600 OTO - NOTNLM OT - Instrument OT - functioning, disability, and health OT - health-related quality of life OT - observer-reported outcome OT - patient-reported outcome OT - pediatric patients OT - proxy report OT - self-report COIS- Moritz I Truninger, Helene Werner, Markus A. Landolt, Andreas Hahn, Dorothea Moslinger, Charlotte Pfrimmer, and Marianne Rohrbach declare that they have no conflict of interest. Martina Huemer has received unrestricted research grants from Nutricia Metabolics and SOBI, and consultancy honoraria or travel support from Aeglea, Chiesi, Nutricia Metabolics, Sanofi, Recordati, and Immedica Pharma, all unrelated to this work. Julia B. Hennermann has received consulting fees/honoraria and/or travel expenses from Chiesi, Amicus, Takeda, and Sanofi, all unrelated to this work. Florian B. Lagler has received unrestricted research grants from Sanofi, Takeda, and Chiesi and honoraria as speaker and consultant from these companies plus Biomarin and Amicus, all unrelated to this work. EDAT- 2024/07/09 12:43 MHDA- 2024/11/25 11:34 PMCR- 2024/11/25 CRDT- 2024/07/09 07:03 PHST- 2024/06/14 00:00 [revised] PHST- 2024/02/21 00:00 [received] PHST- 2024/06/24 00:00 [accepted] PHST- 2024/11/25 11:34 [medline] PHST- 2024/07/09 12:43 [pubmed] PHST- 2024/07/09 07:03 [entrez] PHST- 2024/11/25 00:00 [pmc-release] AID - JIMD12777 [pii] AID - 10.1002/jimd.12777 [doi] PST - ppublish SO - J Inherit Metab Dis. 2024 Nov;47(6):1348-1362. doi: 10.1002/jimd.12777. Epub 2024 Jul 9. PMID- 38978147 OWN - NLM STAT- MEDLINE DCOM- 20240709 LR - 20240802 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 12 IP - 1 DP - 2024 Jul 8 TI - Chinese version of the Tendency to Avoid Physical Activity and Sport (TAPAS) scale: testing unidimensionality, measurement invariance, concurrent validity, and known-group validity among Taiwanese youths. PG - 381 LID - 10.1186/s40359-024-01870-y [doi] LID - 381 AB - BACKGROUND AND OBJECTIVES: Psychosocial factors affect individuals' desire for physical activity. A newly developed instrument (Tendency to Avoid Physical Activity and Sport; TAPAS) has been designed to assess the avoidance of physical activity. Considering cultural differences could be decisive factors, the present study aimed to translate and validate the TAPAS into Chinese (Mandarin) for Taiwanese youths, and further cultural comparisons are expected. METHODS: Standard translation procedure (i.e., forward translation, back translation, and reconciliation) was used to translate the English TAPAS into the Chinese TAPAS. Following translation, 608 youths (mean [SD] age 29.10 [6.36] years; 333 [54.8%] women) participated in the study via a snowballing sampling method with an online survey. All participants completed the Chinese TAPAS and additional instruments assessing weight stigma and psychological distress. Confirmatory factor analysis (CFA) was used to examine the factor structure of the Chinese TAPAS and multigroup CFA to examine measurement invariance across gender (men vs. women) and weight status (overweight vs. non-overweight). Pearson correlations were used to examine the concurrent validity; independent t-tests between gender groups and weight status groups were used to examine the known-group validity. RESULTS: Consistent with the English version, the Chinese TAPAS was found to have a one-factor structure evidenced by CFA results. The structure was invariant across gender and weight status groups evidenced by multigroup CFA results. Concurrent validity was supported by significant associations with the related constructs assessed (r = 0.326 to 0.676; p < 0.001). Known-group validity was supported by the significant differences in TAPAS total scores between gender and weight status groups (p = 0.004 and < 0.001; Cohen's d = 0.24 and 0.48). CONCLUSION: The Chinese version of the TAPAS is a valid and reliable instrument assessing individuals' avoidance of physical activity and sports due to underlying psychosocial issues among Taiwanese youths. It is anticipated to be applied within a large Asian population, as well as cross-cultural comparisons, for further explorations in health, behavioral and epidemiological research and practice. CI - (c) 2024. The Author(s). FAU - Lin, Yi-Ching AU - Lin YC AUID- ORCID: 0000-0002-6835-7116 AD - Department of Early Childhood and Family Education, National Taipei University of Education, Taipei, Taiwan. FAU - Chen, Jung-Sheng AU - Chen JS AUID- ORCID: 0000-0003-3187-9479 AD - Department of Medical Research, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan. FAU - Bevan, Nadia AU - Bevan N AUID- ORCID: 0000-0002-5213-4057 AD - School of Social Sciences, Monash University, Melbourne, 3800, Australia. FAU - O'Brien, Kerry S AU - O'Brien KS AUID- ORCID: 0000-0003-3145-6038 AD - School of Social Sciences, Monash University, Melbourne, 3800, Australia. FAU - Strong, Carol AU - Strong C AUID- ORCID: 0000-0002-2934-5382 AD - Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan. FAU - Tsai, Meng-Che AU - Tsai MC AUID- ORCID: 0000-0003-1057-3315 AD - Department of Pediatrics, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan. AD - Department of Medical Humanities and Social Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. FAU - Fung, Xavier C C AU - Fung XCC AUID- ORCID: 0000-0002-0170-6203 AD - Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China. FAU - Chen, Ji-Kang AU - Chen JK AUID- ORCID: 0000-0001-7762-3888 AD - Department of Social Work, Chinese University of Hong Kong, New Territories, Hong Kong, China. FAU - Lin, I-Ching AU - Lin IC AUID- ORCID: 0000-0002-1418-4977 AD - Department of Healthcare Administration, Department of Family Medicine, Asia University, Taichung, 41354, Taiwan. D52282@auh.org.tw. AD - Department of Family Medicine, Asia University Hospital, Taichung, 41354, Taiwan. D52282@auh.org.tw. AD - Department of Kinesiology, Health, and Leisure, Chienkuo Technology University, Changhua, 50094, Taiwan. D52282@auh.org.tw. FAU - Latner, Janet D AU - Latner JD AD - Department of Psychology, University of Hawaii, Honolulu, HI, 96822, USA. FAU - Lin, Chung-Ying AU - Lin CY AUID- ORCID: 0000-0002-2129-4242 AD - Institute of Allied Health Sciences, Departments of Occupational Therapy and Public Health, and Biostatistics Consulting Center, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, 1 University Rd, Tainan, 701401, Taiwan. cylin36933@gmail.com. AD - University of Religions and Denominations, Qom, Iran. cylin36933@gmail.com. AD - Biostatistics Consulting Center, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan. cylin36933@gmail.com. AD - Faculty of Nursing, Universitas Padjadjaran, Sumedang, Indonesia. cylin36933@gmail.com. LA - eng GR - MOST 110-2410-H-006-115/Ministry of Science and Technology, Taiwan/ GR - 11151007/Asia University Hospital/ PT - Journal Article DEP - 20240708 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM EIN - BMC Psychol. 2024 Jul 31;12(1):418. doi: 10.1186/s40359-024-01912-5. PMID: 39085943 MH - Humans MH - Male MH - Female MH - Taiwan MH - *Exercise/psychology MH - *Sports/psychology MH - Reproducibility of Results MH - *Psychometrics/instrumentation MH - Adult MH - Surveys and Questionnaires/standards MH - Young Adult MH - Adolescent MH - Translations MH - Factor Analysis, Statistical MH - Translating PMC - PMC11232183 OTO - NOTNLM OT - Factor analysis OT - Physical activity OT - Reliability OT - Taiwan OT - Young adults COIS- The authors declare no competing interests. EDAT- 2024/07/09 00:42 MHDA- 2024/07/09 06:42 PMCR- 2024/07/08 CRDT- 2024/07/08 23:53 PHST- 2023/12/24 00:00 [received] PHST- 2024/06/24 00:00 [accepted] PHST- 2024/07/09 06:42 [medline] PHST- 2024/07/09 00:42 [pubmed] PHST- 2024/07/08 23:53 [entrez] PHST- 2024/07/08 00:00 [pmc-release] AID - 10.1186/s40359-024-01870-y [pii] AID - 1870 [pii] AID - 10.1186/s40359-024-01870-y [doi] PST - epublish SO - BMC Psychol. 2024 Jul 8;12(1):381. doi: 10.1186/s40359-024-01870-y. PMID- 38977728 OWN - NLM STAT- MEDLINE DCOM- 20240708 LR - 20240729 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Jul 8 TI - B-cell hub genes play a cardiovascular pathogenic role of in childhood obesity and Kawasaki disease as revealed by transcriptomics-based analyses. PG - 15671 LID - 10.1038/s41598-024-65865-w [doi] LID - 15671 AB - The study aims to explore the central genes that Kawasaki disease (KD) and Obesity (OB) may jointly contribute to coronary artery disease. Investigating single-cell datasets (GSE168732 and GSE163830) from a comprehensive gene expression database, we identified characteristic immune cell subpopulations in KD and OB. B cells emerged as the common immune cell characteristic subgroup in both conditions. Subsequently, we analyzed RNA sequencing datasets (GSE18606 and GSE87493) to identify genes associated with B-cell subpopulations in KD and OB. Lastly, a genome-wide association study and Mendelian randomization were conducted to substantiate the causal impact of these core genes on myocardial infarction. Quantitative real-time PCR (qRT-PCR) to validate the expression levels of hub genes in KD and OB. The overlapping characteristic genes of B cell clusters in both KD and OB yielded 70 shared characteristic genes. PPI analysis led to the discovery of eleven key genes that significantly contribute to the crosstalk. Employing receiver operating characteristic analysis, we evaluated the specificity and sensitivity of these core genes and scored them using Cytoscape software. The inverse variance weighting analysis suggested an association between TNFRSF17 and myocardial infarction risk, with an odds ratio of 0.9995 (95% CI = 0.9990-1.0000, p = 0.049). By employing a single-cell combined transcriptome data analysis, we successfully pinpointed central genes associated with both KD and OB. The implications of these findings extend to shedding light on the increased risk of coronary artery disease resulting from the co-occurrence of OB and KD. CI - (c) 2024. The Author(s). FAU - Chen, Yuan AU - Chen Y AD - Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. FAU - Ji, Xiaoyi AU - Ji X AD - Department of Pediatrics, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Ge, Yao AU - Ge Y AD - Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. FAU - Niu, Huimin AU - Niu H AD - Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. FAU - Zhang, Xinyi AU - Zhang X AD - Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. FAU - Jiang, Feng AU - Jiang F AD - Department of Neonatology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200011, China. dxyjiang@163.com. FAU - Wu, Chuyan AU - Wu C AD - Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. chuyan_w@hotmail.com. LA - eng GR - JSPH-MC-2022-19/Jiangsu Province Hospital (the First Affiliated Hospital with Nanjing Medical University) Clinical Capacity Enhancement Project/ GR - 82172539/the National Natural Science Foundation of China/ PT - Journal Article DEP - 20240708 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - *Mucocutaneous Lymph Node Syndrome/genetics MH - Humans MH - *Pediatric Obesity/genetics MH - *B-Lymphocytes/metabolism/immunology MH - *Genome-Wide Association Study MH - *Transcriptome MH - Child MH - Gene Expression Profiling MH - Male MH - Female MH - Mendelian Randomization Analysis MH - Coronary Artery Disease/genetics/etiology MH - Child, Preschool MH - Myocardial Infarction/genetics MH - Single-Cell Analysis PMC - PMC11231228 OTO - NOTNLM OT - Inflammation OT - Kawasaki disease OT - Mendelian randomization OT - Obesity OT - Single-cell analysis COIS- The authors declare no competing interests. EDAT- 2024/07/09 00:42 MHDA- 2024/07/09 00:43 PMCR- 2024/07/08 CRDT- 2024/07/08 23:29 PHST- 2024/01/17 00:00 [received] PHST- 2024/06/25 00:00 [accepted] PHST- 2024/07/09 00:43 [medline] PHST- 2024/07/09 00:42 [pubmed] PHST- 2024/07/08 23:29 [entrez] PHST- 2024/07/08 00:00 [pmc-release] AID - 10.1038/s41598-024-65865-w [pii] AID - 65865 [pii] AID - 10.1038/s41598-024-65865-w [doi] PST - epublish SO - Sci Rep. 2024 Jul 8;14(1):15671. doi: 10.1038/s41598-024-65865-w. PMID- 38976710 OWN - NLM STAT- MEDLINE DCOM- 20240708 LR - 20260828 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 7 DP - 2024 TI - A randomized cross-over study protocol to evaluate long-term gait training with a pediatric robotic exoskeleton outside the clinical setting in children with movement disorders. PG - e0304087 LID - 10.1371/journal.pone.0304087 [doi] LID - e0304087 AB - Individuals with neuromuscular disorders display a combination of motor control deficits and lower limb weakness contributing to knee extension deficiency characterized by exaggerated stance phase knee flexion. There is a lack of evidence for long-term improvement of knee extension deficiency with currently available clinical treatment programs. Our previous work testing a wearable robotic exoskeleton with precisely timed assistive torque applied at the knee showed immediate increases in knee extension during walking for children with cerebral palsy, which continued to improve over an acute practice period. When we applied interleaved assistance and resistance to knee extension, we observed improvements in knee extension and increased muscle activation indicating the potential for muscle strengthening when used over time. There is a need for additional, high-quality trials to assess the impact of dosage, intensity and volume of training necessary to see persistent improvement in lower limb function for these patient populations. This randomized crossover study (ClinicalTrials.gov: NCT05726591) was designed to determine whether 12 weeks of overground gait training with a robotic exoskeleton outside of the clinical setting, following an initial in clinic accommodation period, has a beneficial effect on walking ability, muscle activity and overall motor function. Participants will be randomized to either complete the exoskeleton intervention or continue their standard therapy for 12 weeks first, followed by a crossover to the other study component. The primary outcome measure is change in peak knee extension angle during walking; secondary outcome measures include gait speed, strength, and validated clinical scales of motor function and mobility. Assessments will be completed before and after the intervention and at 6 weeks post-intervention, and safety and compliance will be monitored throughout. We hypothesize that the 12-week exoskeleton intervention outside the clinical setting will show greater improvements in study outcome measures than the standard therapy. CI - Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. FAU - Devine, Taylor M AU - Devine TM AD - Rehabilitation Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland, United States of America. FAU - Alter, Katharine E AU - Alter KE AD - Rehabilitation Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland, United States of America. FAU - Damiano, Diane L AU - Damiano DL AD - Rehabilitation Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland, United States of America. FAU - Bulea, Thomas C AU - Bulea TC AUID- ORCID: 0000-0002-2732-8255 AD - Rehabilitation Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland, United States of America. LA - eng SI - ClinicalTrials.gov/NCT05726591 GR - ZIA CL090103/ImNIH/Intramural NIH HHS/United States PT - Clinical Trial Protocol PT - Journal Article PT - Research Support, N.I.H., Intramural DEP - 20240708 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Exoskeleton Device MH - Child MH - *Cross-Over Studies MH - *Gait/physiology MH - Male MH - Female MH - Adolescent MH - Movement Disorders/rehabilitation/physiopathology/therapy MH - Cerebral Palsy/rehabilitation/physiopathology MH - Walking/physiology MH - Exercise Therapy/methods/instrumentation MH - Robotics/instrumentation MH - Muscle Strength/physiology MH - Randomized Controlled Trials as Topic PMC - PMC11230531 COIS- The authors have read the journal's policy and have the following competing interests: Thomas C. Bulea and Diane L. Damiano are named inventors on U.S. Patent No. 11,801,153 B2, assigned to the authors' employer (United States Department of Health and Human Services), which covers intellectual property used in the intervention studied in this protocol. This does not alter our adherence to PLOS ONE policies on sharing data and materials. EDAT- 2024/07/08 18:41 MHDA- 2024/07/08 18:42 PMCR- 2024/07/08 CRDT- 2024/07/08 14:54 PHST- 2023/11/13 00:00 [received] PHST- 2024/05/02 00:00 [accepted] PHST- 2024/07/08 18:42 [medline] PHST- 2024/07/08 18:41 [pubmed] PHST- 2024/07/08 14:54 [entrez] PHST- 2024/07/08 00:00 [pmc-release] AID - PONE-D-23-37185 [pii] AID - 10.1371/journal.pone.0304087 [doi] PST - epublish SO - PLoS One. 2024 Jul 8;19(7):e0304087. doi: 10.1371/journal.pone.0304087. eCollection 2024. PMID- 38976477 OWN - NLM STAT- MEDLINE DCOM- 20240925 LR - 20240925 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 63 DP - 2024 Oct TI - Prospective validation of the nutrition screening tool for childhood cancer (SCAN). PG - 304-310 LID - S2405-4577(24)00193-1 [pii] LID - 10.1016/j.clnesp.2024.06.047 [doi] AB - BACKGROUND & AIMS: Different nutritional screening tools have been proposed in childhood cancer, but none has shown convincing predictive capacity so far. The "nutrition screening tool for childhood cancer (SCAN)" has been specifically designed for this population and provides an easy-to-use, promising approach to identify patients at risk of malnutrition. We aim to: 1. Validate the SCAN tool prospectively in identifying malnourished patients or those who required nutritional support 2. Validate the SCAN tool prospectively in predicting toxicities or outcome. 3. Compare performance of a pediatric screening tool (STRONG(KIDS)) with SCAN. METHODS: Children in our center with a new diagnosis of cancer from August 2018 to May 2019 were offered to participate in the study. Measurements (SCAN questionnaire, weight, height, body-mass index (BMI), and mid upper-arm circumference (MUAC)) were taken at diagnosis and at regular intervals throughout therapy. The last measurement was taken 6 months after finishing the intensive treatment phase. SCAN score at diagnosis was validated prospectively against variables of interest. RESULTS: A total of 49 patients were recruited. When considering malnutrition during therapy the SCAN tool showed a sensitivity of 37.5% and negative predictive value (NPV) of 81%. Patients who required nutritional support were identified with a sensitivity of 50% and NPV of 62%. The SCAN tool was not able to predict increased toxicities, risk of relapse or decreased survival. The pediatric screening tool STRONG(KIDS) was unable to discriminate nutritional risk and labeled all 49 patients (100%) as medium or high-risk. Applying SCAN periodically during therapy increased sensitivity for identifying malnutrition to 87.5%. CONCLUSIONS: In our study, applying the SCAN tool at diagnosis showed low sensitivity in identifying patients who go on to develop malnutrition during therapy. However, patients labeled as "not at risk" were unlikely to need nutritional support in the form of nasogastric tube or total parenteral nutrition. Using SCAN throughout therapy could be helpful in building awareness for malnutrition and successfully discriminates between patients who need further support and those who don't. CI - Copyright (c) 2024 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. FAU - de Oliveira Canedo, Gustavo AU - de Oliveira Canedo G AD - Department of Pediatric Hematology-Oncology, Hospital Infantil Universitario Nino Jesus, Madrid, Spain. Electronic address: gustavo.canedo@gmail.com. FAU - Palomino Perez, Laura Maria AU - Palomino Perez LM AD - Department of Pediatric Gastroenterology and Nutrition, Hospital Infantil Universitario Nino Jesus, Madrid, Spain. FAU - Puerta Macfarland, Laura Andrea AU - Puerta Macfarland LA AD - Department of Pediatric Gastroenterology and Nutrition, Hospital Infantil Universitario Nino Jesus, Madrid, Spain. FAU - Ruano Dominguez, David AU - Ruano Dominguez D AD - Department of Pediatric Hematology-Oncology, Hospital Infantil Universitario Nino Jesus, Madrid, Spain. FAU - Canedo-Villaroya, Elvira AU - Canedo-Villaroya E AD - Department of Pediatric Gastroenterology and Nutrition, Hospital Infantil Universitario Nino Jesus, Madrid, Spain. FAU - Garcia Alcolea, Beatriz AU - Garcia Alcolea B AD - Department of Pediatric Gastroenterology and Nutrition, Hospital Infantil Universitario Nino Jesus, Madrid, Spain. FAU - Madero Lopez, Luis AU - Madero Lopez L AD - Department of Pediatric Hematology-Oncology, Hospital Infantil Universitario Nino Jesus, Madrid, Spain. FAU - Pedron-Giner, Consuelo AU - Pedron-Giner C AD - Department of Pediatric Gastroenterology and Nutrition, Hospital Infantil Universitario Nino Jesus, Madrid, Spain. LA - eng PT - Journal Article PT - Validation Study DEP - 20240702 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM MH - Humans MH - *Neoplasms MH - Child MH - Female MH - Prospective Studies MH - Male MH - *Nutrition Assessment MH - Child, Preschool MH - *Malnutrition/diagnosis MH - *Nutritional Status MH - Adolescent MH - Body Mass Index MH - Infant MH - Mass Screening/methods MH - Surveys and Questionnaires MH - Reproducibility of Results MH - Nutritional Support MH - Predictive Value of Tests MH - Sensitivity and Specificity OTO - NOTNLM OT - Nutrition and cancer OT - Nutritional screening OT - Pediatric hematology-oncology OT - SCAN COIS- Declaration of competing interest The authors disclose no financial interests or conflicts of interest. EDAT- 2024/07/08 18:42 MHDA- 2024/09/25 10:18 CRDT- 2024/07/08 12:36 PHST- 2024/05/16 00:00 [received] PHST- 2024/06/26 00:00 [revised] PHST- 2024/06/27 00:00 [accepted] PHST- 2024/09/25 10:18 [medline] PHST- 2024/07/08 18:42 [pubmed] PHST- 2024/07/08 12:36 [entrez] AID - S2405-4577(24)00193-1 [pii] AID - 10.1016/j.clnesp.2024.06.047 [doi] PST - ppublish SO - Clin Nutr ESPEN. 2024 Oct;63:304-310. doi: 10.1016/j.clnesp.2024.06.047. Epub 2024 Jul 2. PMID- 38972789 OWN - NLM STAT- MEDLINE DCOM- 20241127 LR - 20260505 IS - 1878-3562 (Electronic) IS - 1590-8658 (Print) IS - 1590-8658 (Linking) VI - 56 IP - 12 DP - 2024 Dec TI - A clinical predictive model identifies pediatric patients at risk for eosinophilic esophagitis. PG - 2045-2051 LID - S1590-8658(24)00829-6 [pii] LID - 10.1016/j.dld.2024.06.019 [doi] AB - BACKGROUND: Identifying children needing endoscopic evaluation for suspected eosinophilic esophagitis (EoE) is crucial for prompt diagnosis and management. AIMS: We aimed to develop a clinical prediction tool to distinguish children with EoE from children without the disease before endoscopy. METHODS: We conducted a retrospective case-control study of children undergoing upper endoscopy at a tertiary care center. Clinical characteristics before endoscopy were extracted from 380 EoE cases and 380 controls without EoE. We built a predictive model for case-control status and performed age-stratified analyses. RESULTS: After multivariable analysis, history of adaptive eating behaviors, food allergy, food impaction, male sex, and regurgitation were independently associated with EoE, and abdominal pain and failure to thrive with control status (AUC 0.81). Food allergy and male sex were predictors of EoE across all ages. Regurgitation and adaptive eating behaviors were specific to EoE in early (0-5 years) (AUC 0.74) and middle childhood (6-11 years) (AUC 0.82), while dysphagia and food impaction were specific to EoE in the adolescence (12-17 years) (AUC 0.87). CONCLUSION: We determined age-specific clinical features that predict EoE with good discrimination in a pediatric population before endoscopy. Validation of this model in an independent population can confirm the utility of this tool. CI - Copyright (c) 2024 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. FAU - Borinsky, Stephanie A AU - Borinsky SA AD - Pediatric Gastroenterology, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USA. FAU - Miller, Talya L AU - Miller TL AD - Swedish Digestive Health Institute, Swedish Medical Center, Seattle, WA, USA. FAU - Dellon, Evan S AU - Dellon ES AD - Center for Esophageal Diseases and Swallowing and Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA. Electronic address: edellon@med.unc.edu. LA - eng GR - T32 HD094671/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20240706 PL - Netherlands TA - Dig Liver Dis JT - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JID - 100958385 SB - IM MH - Humans MH - *Eosinophilic Esophagitis/diagnosis/epidemiology MH - Male MH - Female MH - Child MH - Retrospective Studies MH - Child, Preschool MH - Adolescent MH - Case-Control Studies MH - Infant MH - Food Hypersensitivity/complications/diagnosis MH - Risk Factors MH - Deglutition Disorders/etiology MH - Risk Assessment MH - Multivariate Analysis MH - Infant, Newborn PMC - PMC11602386 MID - NIHMS2006993 OTO - NOTNLM OT - Children OT - Endoscopy OT - Esophagus OT - Food allergy COIS- Conflict of Interest None of the authors have any potential conflicts related to this paper to disclose. EDAT- 2024/07/08 00:43 MHDA- 2024/11/28 00:24 PMCR- 2025/12/01 CRDT- 2024/07/07 21:56 PHST- 2024/02/05 00:00 [received] PHST- 2024/06/19 00:00 [revised] PHST- 2024/06/20 00:00 [accepted] PHST- 2024/11/28 00:24 [medline] PHST- 2024/07/08 00:43 [pubmed] PHST- 2024/07/07 21:56 [entrez] PHST- 2025/12/01 00:00 [pmc-release] AID - S1590-8658(24)00829-6 [pii] AID - 10.1016/j.dld.2024.06.019 [doi] PST - ppublish SO - Dig Liver Dis. 2024 Dec;56(12):2045-2051. doi: 10.1016/j.dld.2024.06.019. Epub 2024 Jul 6. PMID- 38972309 OWN - NLM STAT- MEDLINE DCOM- 20241216 LR - 20260723 IS - 1421-976X (Electronic) IS - 0008-6568 (Print) IS - 0008-6568 (Linking) VI - 58 IP - 6 DP - 2024 TI - Salivary Proteins and Metabolites as Caries Biomarkers in Adolescents. PG - 573-588 LID - 10.1159/000540090 [doi] AB - INTRODUCTION: The identification of salivary molecules that can be associated to dental caries could provide insights about caries risk and offer valuable information to develop caries prediction models. However, the search for a universal caries biomarker has proven elusive due to the multifactorial nature of this oral disease. We have therefore performed a systematic effort to identify caries-associated metabolites and proteins in saliva samples from adolescents that had a caries experience and those that were caries-free. METHODS: Quantification of approximately 100 molecules was performed by the use of a wide range of techniques, ranging from nuclear magnetic resonance metabolomics to ELISA, Luminex or colorimetric assays, as well as clinical features like plaque accumulation and gingival index. In addition, simplified dietary and oral hygiene habits questionnaires were also obtained. RESULTS: The caries-free group had significantly lower consumption of sweetened beverages and higher tooth brushing frequency. Surprisingly, very few compounds were found to individually provide discriminatory power between caries-experienced and caries-free individuals. The data analysis revealed several potential reasons that could underly this lack of association value with caries, including differences in metabolite concentrations throughout the day, a lack of correlation between metabolite concentrations in plaque and saliva, or sex-related differences, among others. However, when multiple compounds were combined by multivariate analysis and random forest modeling, a combination of 3-5 compounds were found to provide good prediction models for morning (with an AUC accuracy of 0.87) and especially afternoon samples (AUC = 0.93). CONCLUSION: While few salivary biomarkers could differentiate between caries-free and caries-experienced adolescents, a combination of markers proved effective, particularly in afternoon samples. To predict caries risk, these biomarkers should be validated in larger cohorts and longitudinal settings, considering factors such as gender differences, and variations in oral hygiene and diet. CI - (c) 2024 The Author(s). Published by S. Karger AG, Basel. FAU - Havsed, Kristian AU - Havsed K AD - Section for Oral Biology and Pathology, Faculty of Odontology, Malmo University, Malmo, Sweden. AD - Department of Pediatric Dentistry, Institute for Postgraduate Dental Education, Jonkoping, Sweden. AD - Centre for Oral Health, School of Health and Welfare, Jonkoping University, Jonkoping, Sweden. FAU - Carda-Dieguez, Miguel AU - Carda-Dieguez M AD - Department of Health and Genomics, FISABIO Foundation, Valencia, Spain. FAU - Isaksson, Helen AU - Isaksson H AD - Department of Pediatric Dentistry, Institute for Postgraduate Dental Education, Jonkoping, Sweden. AD - Centre for Oral Health, School of Health and Welfare, Jonkoping University, Jonkoping, Sweden. FAU - Stensson, Malin AU - Stensson M AD - Centre for Oral Health, School of Health and Welfare, Jonkoping University, Jonkoping, Sweden. FAU - Carlsson, Emma AU - Carlsson E AD - Centre for Oral Health, School of Health and Welfare, Jonkoping University, Jonkoping, Sweden. FAU - Jansson, Henrik AU - Jansson H AD - Folktandvarden Skane, Lund, Sweden. FAU - Malmodin, Daniel AU - Malmodin D AD - Swedish NMR Centre, The University of Gothenburg, Gothenburg, Sweden. AD - National Bioinformatics Infrastructure Sweden (NBIS), Gothenburg, Sweden. FAU - Nord, Anders Bay AU - Nord AB AD - Swedish NMR Centre, The University of Gothenburg, Gothenburg, Sweden. FAU - Wickstrom, Claes AU - Wickstrom C AD - Section for Oral Biology and Pathology, Faculty of Odontology, Malmo University, Malmo, Sweden. AD - Biofilms - Research Center for Biointerfaces, Malmo University, Malmo, Sweden. FAU - Mira, Alex AU - Mira A AD - Centre for Oral Health, School of Health and Welfare, Jonkoping University, Jonkoping, Sweden. AD - Department of Health and Genomics, FISABIO Foundation, Valencia, Spain. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240717 PL - Switzerland TA - Caries Res JT - Caries research JID - 0103374 RN - 0 (Biomarkers) RN - 0 (Salivary Proteins and Peptides) SB - IM EIN - Caries Res. 2026;60(2):219-220. doi: 10.1159/000550544. PMID: 41701650 MH - Humans MH - *Dental Caries/metabolism MH - *Biomarkers/analysis/metabolism MH - Adolescent MH - Female MH - Male MH - *Salivary Proteins and Peptides/analysis/metabolism MH - *Saliva/chemistry/metabolism MH - Oral Hygiene MH - Toothbrushing MH - Enzyme-Linked Immunosorbent Assay MH - DMF Index MH - Dental Plaque/metabolism MH - Periodontal Index MH - Metabolomics MH - Feeding Behavior MH - Colorimetry MH - Sex Factors MH - Dental Plaque Index MH - Magnetic Resonance Spectroscopy/methods MH - Case-Control Studies PMC - PMC11651229 OTO - NOTNLM OT - Adolescents OT - Biomarkers OT - Caries risk OT - Dental caries OT - Metabolome OT - Nuclear magnet resonance OT - Saliva COIS- The authors have no conflicts of interest to declare. EDAT- 2024/07/08 00:43 MHDA- 2024/12/17 05:31 PMCR- 2024/07/17 CRDT- 2024/07/07 18:23 PHST- 2024/02/02 00:00 [received] PHST- 2024/06/21 00:00 [accepted] PHST- 2024/12/17 05:31 [medline] PHST- 2024/07/08 00:43 [pubmed] PHST- 2024/07/07 18:23 [entrez] PHST- 2024/07/17 00:00 [pmc-release] AID - 000540090 [pii] AID - 540090 [pii] AID - 10.1159/000540090 [doi] PST - ppublish SO - Caries Res. 2024;58(6):573-588. doi: 10.1159/000540090. Epub 2024 Jul 17. PMID- 38970369 OWN - NLM STAT- MEDLINE DCOM- 20250210 LR - 20260917 IS - 1536-4844 (Electronic) IS - 1078-0998 (Linking) VI - 31 IP - 2 DP - 2025 Feb 6 TI - Following Through: The Impact of Culinary Medicine on Mediterranean Diet Uptake in Inflammatory Bowel Disease. PG - 404-410 LID - 10.1093/ibd/izae141 [doi] AB - BACKGROUND: The Mediterranean diet (MD) is recommended for all patients with inflammatory bowel disease (IBD) unless there is a specific contraindication. Culinary medicine has emerged as a method for improving dietary education. Patients and caregivers are often invested in making dietary changes to improve disease control. Here, we examine the dietary preferences of a group of young people with IBD and apply culinary medicine techniques with an in-person MD-focused cooking class. METHODS: A survey evaluating dietary attitudes was sent to an IBD email listserv at our tertiary care center (n = 779). A validated questionnaire, the Mediterranean Diet Quality Index for Children and Adolescents was used to assess MD adherence. IBD dietitians customized 2 in-person MD-focused cooking classes, one for children 6 to 12 years of age (arm 1) and one for adolescents 13 to 17 years of age (arm 2). Baseline, 1-month follow-up, and 3-month follow-up surveys were completed. RESULTS: There were 112 survey responses. Participants were 67.0% male with diagnosis of Crohn's disease (50.0%), ulcerative colitis (42.0%), or IBD unclassified (8.0%). Most were managed on advanced therapies (82.0%). Most reported making decisions about diet (82.0%) in order to help with IBD, had met with a dietitian (69.0%), and were interested in learning more about the MD (55.3%). MD scores were primarily in the average (49.5%) and poor (41.1%) diet categories. Only those eating together as a family 3 or more times per week or those who had met with a dietitian scored in the optimal diet category. The median MD score at baseline was 4.5, increasing to 6.0 at 1 month and 7.0 at 3 months postintervention. Almost all (90%) would recommend cooking classes to others. Common barriers to MD uptake included lack of knowledge about which foods to prepare, concern about taste, and time to prepare food. CONCLUSIONS: This study showcases high patient and caregiver interest in dietary management of IBD and demonstrates efficacy of education via application of culinary medicine. Classes were well received by families and MD adherence scores increased postintervention. As patients with IBD and their families are often motivated to incorporate dietary therapy into their care, this work highlights the role of culinary medicine and value of future study. CI - (c) The Author(s) 2024. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Ryan, Kelsey AU - Ryan K AUID- ORCID: 0009-0002-1280-1326 AD - Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. FAU - Salozzo, Caroline AU - Salozzo C AD - Department of Clinical Nutrition, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA. FAU - Schwartz, Sally AU - Schwartz S AD - Department of Clinical Nutrition, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA. FAU - Hart, Micquel AU - Hart M AD - Section of Gastroenterology, Hepatology and Nutrition, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA. FAU - Tuo, Ya AU - Tuo Y AD - Stanley Manne Children's Research Institute, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA. FAU - Wenzel, Amanda AU - Wenzel A AD - Section of Gastroenterology, Hepatology and Nutrition, Children's Wisconsin, Medical College of Wisconsin, Milwaukee, WI 53226, USA. FAU - Saul, Samantha AU - Saul S AD - Section of Gastroenterology, C.S. Mott Children's Hospital, University of Michigan Medicine, Ann Arbor, MI 48109, USA. FAU - Strople, Jennifer AU - Strople J AD - Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. AD - Section of Gastroenterology, Hepatology and Nutrition, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA. FAU - Brown, Jeffrey AU - Brown J AD - Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. AD - Section of Gastroenterology, Hepatology and Nutrition, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA. FAU - Runde, Joseph AU - Runde J AD - Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. AD - Section of Gastroenterology, Hepatology and Nutrition, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA. LA - eng GR - Stanley Manne Resident Research/ PT - Journal Article PL - England TA - Inflamm Bowel Dis JT - Inflammatory bowel diseases JID - 9508162 SB - IM MH - Humans MH - *Diet, Mediterranean/statistics & numerical data MH - Male MH - Female MH - Adolescent MH - Child MH - *Inflammatory Bowel Diseases/diet therapy MH - Surveys and Questionnaires MH - *Cooking/methods MH - Follow-Up Studies MH - *Colitis, Ulcerative/diet therapy MH - *Patient Compliance OAB - As the Mediterranean diet is now recommended for all patients with inflammatory bowel disease, we have shown high interest in dietary therapy and applied culinary medicine techniques as a valuable tool for increasing diet uptake in an effort to improve outcomes. OABL- eng OTO - NOTNLM OT - Mediterranean diet OT - cooking OT - dietary therapy OT - inflammatory bowel disease OT - pediatrics EDAT- 2024/07/06 20:42 MHDA- 2025/02/10 12:22 CRDT- 2024/07/06 04:13 PHST- 2024/03/20 00:00 [received] PHST- 2025/02/10 12:22 [medline] PHST- 2024/07/06 20:42 [pubmed] PHST- 2024/07/06 04:13 [entrez] AID - 7708456 [pii] AID - 10.1093/ibd/izae141 [doi] PST - ppublish SO - Inflamm Bowel Dis. 2025 Feb 6;31(2):404-410. doi: 10.1093/ibd/izae141. PMID- 38969814 OWN - NLM STAT- MEDLINE DCOM- 20250507 LR - 20260831 IS - 1530-0447 (Electronic) IS - 0031-3998 (Print) IS - 0031-3998 (Linking) VI - 97 IP - 3 DP - 2025 Feb TI - Long-term developmental outcomes of children with congenital Zika syndrome. PG - 989-993 LID - 10.1038/s41390-024-03389-9 [doi] AB - BACKGROUND: Eight years after the epidemics in Brazil, children with congenital Zika syndrome (CZS) and their families confront ongoing health challenges. OBJECTIVE: This study aims to characterize how virally induced prenatal brain injury impacts development and functional outcomes among children diagnosed with CZS. METHODS: We performed a cross-sectional study of a consecutive series of children diagnosed with CZS. Using validated neurodevelopmental assessments, we evaluated gross motor function, manual ability, communication, eating and drinking, and visual function. RESULTS: Sixty children (29 males, and 31 females) met the inclusion criteria for the study. Comorbidities such as epilepsy (90.0%) and undernutrition (38.3%), along with clinical conditions including dysphagia (68.3%) and dependence on tube feeding (31.7%), were observed. Our results demonstrate a majority of children at level V - the most severe level within a five-tier system - in the Gross Motor Function (86.7%), Manual Ability (85.0%), Communication Function (68.3%), Eating and Drinking Ability (40.0%) Classification Systems, and level IV in the Visual Function Classification System (38.3%). CONCLUSION: CZS is associated with severe functional impairments and comorbidities, adversely impacting child development and quality of life. These findings reveal persistent challenges affecting the functioning of children with CZS, underscoring the need for continued support and specialized care. IMPACT: This study aimed to characterize the long-term clinical and functional characteristics of a subset of children with Congenital Zika Syndrome (CZS). We found that eight years after the Brazilian Zika epidemic, this subset of children with CZS continues to demonstrate major functional limitations impacting mobility, vision, and the ability to eat and drink. Our analysis documented a very high level of disability in several key functional classification systems. Notably, applying a new instrument for visual ability among children diagnosed with cerebral palsy, we found that more than 60% of the study group have poor or very poor visual function. CI - (c) 2024. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - Marques, Fernanda J P AU - Marques FJP AUID- ORCID: 0000-0001-6826-7084 AD - SARAH Network Rehabilitation Hospitals, Rio de Janeiro, Rio de Janeiro, Brazil. fernandajpmarques@gmail.com. FAU - Tran, Lani AU - Tran L AUID- ORCID: 0009-0000-9213-6412 AD - Center for Neuroscience, Children's National Research Institute, Washington, DC, USA. AD - Center for Genetic Medicine Research, Children's National Research Institute, Washington, DC, USA. FAU - Kousa, Youssef A AU - Kousa YA AUID- ORCID: 0000-0001-6049-8144 AD - Center for Neuroscience, Children's National Research Institute, Washington, DC, USA. AD - Center for Genetic Medicine Research, Children's National Research Institute, Washington, DC, USA. AD - Department of Neurology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA. AD - Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, USA. FAU - Leyser, Marcio AU - Leyser M AUID- ORCID: 0000-0002-2929-8416 AD - Stead Family Department of Pediatrics, Division of Developmental and Behavioral Pediatrics, University of Iowa, Iowa City, IA, USA. LA - eng GR - K08 NS119882/NS/NINDS NIH HHS/United States GR - L40 HD102847/HD/NICHD NIH HHS/United States GR - K08NS119882/NH/NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20240705 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM MH - Humans MH - *Zika Virus Infection/congenital/complications/physiopathology/epidemiology MH - Female MH - Male MH - Cross-Sectional Studies MH - Child MH - Child, Preschool MH - Brazil/epidemiology MH - *Child Development MH - Infant MH - Zika Virus MH - Comorbidity MH - *Developmental Disabilities PMC - PMC12832034 MID - NIHMS2139143 COIS- Competing interests: The authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article. Ethical approval and consent statement: Ethical approval was granted by the internal review board (protocol CAAE 52305621.3.0000.0022). Families of participants provided informed consent for this study at SARAH Network Rehabilitation Hospitals. EDAT- 2024/07/06 10:43 MHDA- 2025/05/07 06:27 PMCR- 2026/01/25 CRDT- 2024/07/05 23:26 PHST- 2024/01/23 00:00 [received] PHST- 2024/06/19 00:00 [accepted] PHST- 2024/06/07 00:00 [revised] PHST- 2025/05/07 06:27 [medline] PHST- 2024/07/06 10:43 [pubmed] PHST- 2024/07/05 23:26 [entrez] PHST- 2026/01/25 00:00 [pmc-release] AID - 10.1038/s41390-024-03389-9 [pii] AID - 10.1038/s41390-024-03389-9 [doi] PST - ppublish SO - Pediatr Res. 2025 Feb;97(3):989-993. doi: 10.1038/s41390-024-03389-9. Epub 2024 Jul 5. PMID- 38969377 OWN - NLM STAT- MEDLINE DCOM- 20240705 LR - 20250204 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 14 IP - 7 DP - 2024 Jul 5 TI - Association between ultra-processed food consumption, sociodemographic characteristics, malnutrition and obesity among urban school-aged children in Lilongwe, Malawi: a cross-sectional study. PG - e084120 LID - 10.1136/bmjopen-2024-084120 [doi] LID - e084120 AB - INTRODUCTION: The escalating consumption of ultra-processed foods (UPFs) among school-aged children in developing countries poses a significant threat to public health, contributing to the dual burden of malnutrition. In Malawi, where undernutrition coexists with a burgeoning obesity epidemic, understanding the determinants of UPF consumption and its impact on children's nutritional status is imperative. This study, conducted in Lilongwe, Malawi, aimed to investigate the association between UPF consumption, sociodemographic factors and the nutritional status of school-aged children. MATERIALS AND METHODS: 511 children aged 7-14 were recruited from 2 densely populated townships using systematic random sampling. Data on sociodemographic factors, UPF consumption and nutritional status were collected through face-to-face interviews and anthropometric measurements. UPF consumption was assessed using a validated Food Frequency Questionnaire while multinomial logistic regression was employed to analyse associations. RESULTS: Results revealed alarmingly high UPF consumption among children, particularly those high in sugar. Multinomial logistic regression identified significant predictors of malnutrition outcomes. Notably, children consuming UPFs more than three times a week were more likely to be malnourished. Overweight status was positively associated with sausage intake (beta=0.226, adjusted OR 1.254, 95% CI 1.004 to 1.566, p=0.046) and age (beta=0.020, adjusted OR=0.257, 95% CI 0.156 to 0.28, p=0.003). Conversely, underweight status was linked with residential location (beta=4.507, adjusted OR 0.01, 95% CI 0.000 to 0.281, p=0.006) and fizzy drinks (beta=1.071, adjusted OR 2.919, 95% CI 1.413 to 6.028, p=0.004). CONCLUSION: The high prevalence of UPF consumption among school-aged children is significantly associated with malnutrition. Moreover, sociodemographic factors influence UPF consumption, highlighting the need for targeted interventions to reduce malnutrition. These findings may inform public health policies to mitigate malnutrition among children in Malawi's urban communities. CI - (c) Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Kamanga, Patricia AU - Kamanga P AUID- ORCID: 0000-0001-9983-9751 AD - Food Safety and Health Research Centre, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China triciakamz@gmail.com. AD - Surgical Department, Kamuzu Central Hospital, Lilongwe, Malawi. FAU - Zhang, Bo AU - Zhang B AUID- ORCID: 0000-0003-1208-5489 AD - Food Safety and Health Research Centre, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China. FAU - Kaphera, Samson AU - Kaphera S AD - Surgical Department, Kamuzu Central Hospital, Lilongwe, Malawi. FAU - Mwale, Senzya AU - Mwale S AD - Kamuzu University of Health Sciences, Blantyre, Malawi. FAU - Koroma, Mark Momoh AU - Koroma MM AD - Southern Medical University, Guangzhou, Guangdong, China. LA - eng PT - Journal Article DEP - 20240705 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Malawi/epidemiology MH - Child MH - Male MH - Female MH - Cross-Sectional Studies MH - *Fast Foods/statistics & numerical data MH - Adolescent MH - *Pediatric Obesity/epidemiology MH - *Malnutrition/epidemiology MH - Urban Population/statistics & numerical data MH - Nutritional Status MH - Socioeconomic Factors MH - Logistic Models MH - Food, Processed PMC - PMC11227777 OTO - NOTNLM OT - community child health OT - nutrition OT - obesity OT - overweight COIS- Competing interests: None declared. EDAT- 2024/07/06 10:43 MHDA- 2024/07/06 10:44 PMCR- 2024/07/05 CRDT- 2024/07/05 20:52 PHST- 2024/07/06 10:44 [medline] PHST- 2024/07/06 10:43 [pubmed] PHST- 2024/07/05 20:52 [entrez] PHST- 2024/07/05 00:00 [pmc-release] AID - bmjopen-2024-084120 [pii] AID - 10.1136/bmjopen-2024-084120 [doi] PST - epublish SO - BMJ Open. 2024 Jul 5;14(7):e084120. doi: 10.1136/bmjopen-2024-084120. PMID- 38968502 OWN - NLM STAT- MEDLINE DCOM- 20240705 LR - 20250504 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 103 IP - 27 DP - 2024 Jul 5 TI - The measured healthy lifestyle habits among Saudi university females in Medina, Saudi Arabia: A cross-sectional study. PG - e38712 LID - 10.1097/MD.0000000000038712 [doi] LID - e38712 AB - Lifestyle plays a crucial role in shaping an individual's health outcomes, we aim to calculate the prevalence of lifestyle habits among female populations in the College of Medicine, Taibah University including poor dietary habits, lack of physical activity (PA), poor coping with stress, and impaired sleep patterns and to find factors that are correlated to them. A cross-sectional study was conducted among Saudi females at the College of Medicine, Taibah University, from January 1 to June 1, 2023. Data were collected through interviewing them using validated questionnaires assessing 5 different lifestyle domains. Statistical analysis was performed using Statistical Package for the Social Sciences version 21.0. A total of 263 cases were interviewed. The mean age was 22 +/- 8.4 years old. The average sleep quality measured by the Pittsburgh Sleep Quality Index of 2.6 +/- 1.1, suggesting relative difficulty in sleep quality. A total of 68.6% participated in moderate PA. Dietary habits indicated a high prevalence of consumption of sweets, and fast meals, alongside low intake of fruits and vegetables. Emotional well-being, as assessed by the World Health Organization-5 questionnaire, yielded an average score of 7.8 +/- 5.7, 58.9% moderate stress, and 8% high perceived stress. Adequate sleep quality is crucial for well-being, necessitating lifestyle modifications, particularly weight management, to address sleep disorders. Varied PA levels (46% meeting recommendations) highlight the need for standardized guidelines and tailored interventions. The high prevalence of unhealthy dietary habits underscores the importance of targeted nutritional interventions. Stress prevalence (40%) emphasizes the need for individualized stress management strategies. CI - Copyright (c) 2024 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Surrati, Amal M Qasem AU - Surrati AMQ AUID- ORCID: 0000-0002-6433-8508 AD - Family and Community Medicine Department, College of Medicine, Taibah University, Medina, Saudi Arabia. FAU - Altayeb, Eilaf Hasan AU - Altayeb EH AD - College of Medicine, Taibah University, Medina, Saudi Arabia. FAU - Almohammadi, Wedyan Ali AU - Almohammadi WA AD - College of Medicine, Taibah University, Medina, Saudi Arabia. FAU - Aljohani, Rahaf Mustafa AU - Aljohani RM AD - College of Medicine, Taibah University, Medina, Saudi Arabia. FAU - Altouri, Haya Shaher Ali AU - Altouri HSA AD - College of Medicine, Taibah University, Medina, Saudi Arabia. FAU - Alhawsawi, Rahaf Abdullah AU - Alhawsawi RA AD - College of Medicine, Taibah University, Medina, Saudi Arabia. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Female MH - Saudi Arabia/epidemiology MH - Cross-Sectional Studies MH - Adult MH - Young Adult MH - *Exercise MH - Universities MH - *Feeding Behavior/psychology MH - *Healthy Lifestyle MH - Surveys and Questionnaires MH - Sleep Quality MH - Adolescent MH - Stress, Psychological/epidemiology MH - Adaptation, Psychological PMC - PMC11224813 COIS- The authors have no funding and conflicts of interest to disclose. EDAT- 2024/07/05 18:42 MHDA- 2024/07/05 18:43 PMCR- 2024/07/05 CRDT- 2024/07/05 15:33 PHST- 2024/07/05 18:43 [medline] PHST- 2024/07/05 18:42 [pubmed] PHST- 2024/07/05 15:33 [entrez] PHST- 2024/07/05 00:00 [pmc-release] AID - 00005792-202407050-00052 [pii] AID - MD-D-24-04321 [pii] AID - 10.1097/MD.0000000000038712 [doi] PST - ppublish SO - Medicine (Baltimore). 2024 Jul 5;103(27):e38712. doi: 10.1097/MD.0000000000038712. PMID- 38968033 OWN - NLM STAT- MEDLINE DCOM- 20240927 LR - 20240927 IS - 1878-7401 (Electronic) IS - 0928-7329 (Linking) VI - 32 IP - 5 DP - 2024 TI - Analysis of risk factors and construction of a predictive model for macrosomia in deliveries with gestational diabetes. PG - 3595-3604 LID - 10.3233/THC-240679 [doi] AB - BACKGROUND: Gestational diabetes, a frequent pregnancy complication marked by elevated maternal blood glucose, can cause serious adverse effects for both mother and fetus, including increased amniotic fluid and risks of fetal asphyxia, hypoxia, and premature birth. OBJECTIVE: To construct a predictive model to analyze the risk factors for macrosomia in deliveries with gestational diabetes. METHODS: From January 2021 to February 2023, 362 pregnant women with gestational diabetes were selected for the study. They were followed up until delivery. Based on newborn birth weight, the participants were divided into the macrosomia group (birth weight ⩾ 4000 g) and the non-macrosomia group (birth weight < 4000 g). The data of the two groups of pregnant women were compared. ROC curves were plotted to analyze the predictive value of multiple factors for the delivery of macrosomic infants among pregnant women with gestational diabetes. A logistic regression model was constructed to identify the risk factors for delivering macrosomic infants and the model was tested. RESULTS: A total of 362 pregnant women with gestational diabetes were included, of which 58 (16.02%) had babies with macrosomia. The macrosomia group exhibited higher metrics in several areas compared to those without: pre-pregnancy BMI, fasting glucose, 1 h and 2 h OGTT sugar levels, weight gain during pregnancy, and levels of triglycerides, LDL-C, and HDL-C, all with significant differences (P< 0.05). ROC analysis revealed predictive value for macrosomia with AUCs of 0.761 (pre-pregnancy BMI), 0.710 (fasting glucose), 0.671 (1 h OGTT), 0.634 (2 h OGTT), 0.850 (weight gain), 0.837 (triglycerides), 0.742 (LDL-C), and 0.776 (HDL-C), indicating statistical significance (P< 0.05). Logistic regression identified high pre-pregnancy BMI, fasting glucose, weight gain, triglycerides, and LDL-C levels as independent risk factors for macrosomia, with odds ratios of 2.448, 2.730, 1.884, 16.919, and 5.667, respectively, and all were statistically significant (P< 0.05). The model's AUC of 0.980 (P< 0.05) attests to its reliability and stability. CONCLUSION: The delivery of macrosomic infants in gestational diabetes may be related to factors such as body mass index before pregnancy, blood-glucose levels, gain weight during pregnancy, and lipid levels. Clinical interventions targeting these factors should be implemented to reduce the incidence of macrosomia. FAU - Dou, Fengjiao AU - Dou F AD - Shaoxing University Yuanpei College, Shaoxing, China. FAU - Tian, Qingxiu AU - Tian Q AD - Department of Endocrinology, The First Affiliated Hospital of Shandong First Medical University, Shandong Provincial Qianfoshan Hospital, Jinan, China. FAU - Zhang, Ran AU - Zhang R AD - Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. LA - eng PT - Journal Article PL - United States TA - Technol Health Care JT - Technology and health care : official journal of the European Society for Engineering and Medicine JID - 9314590 RN - 0 (Blood Glucose) SB - IM MH - Humans MH - Pregnancy MH - Female MH - *Diabetes, Gestational/epidemiology MH - *Fetal Macrosomia/epidemiology MH - Risk Factors MH - Adult MH - ROC Curve MH - Birth Weight MH - Infant, Newborn MH - Logistic Models MH - Blood Glucose/analysis MH - Body Mass Index OTO - NOTNLM OT - Gestational diabetes OT - delivery OT - macrosomia OT - predictive model OT - risk factors EDAT- 2024/07/05 18:42 MHDA- 2024/09/27 12:42 CRDT- 2024/07/05 12:32 PHST- 2024/09/27 12:42 [medline] PHST- 2024/07/05 18:42 [pubmed] PHST- 2024/07/05 12:32 [entrez] AID - THC240679 [pii] AID - 10.3233/THC-240679 [doi] PST - ppublish SO - Technol Health Care. 2024;32(5):3595-3604. doi: 10.3233/THC-240679. PMID- 38966696 OWN - NLM STAT- MEDLINE DCOM- 20240705 LR - 20260604 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 12 DP - 2024 TI - Effectiveness of a program to lower unwanted media screens among 2-5-year-old children: a randomized controlled trial. PG - 1304861 LID - 10.3389/fpubh.2024.1304861 [doi] LID - 1304861 AB - BACKGROUND: Limited interventions exist on reducing unwanted screen time (ST) among children from low- and middle-income countries (LMICs), so we developed and assessed the effectiveness of the program to lower unwanted media screen time (PLUMS) among children aged 2-5 years in Chandigarh, Union Territory, North India. METHODS: An open-label randomized control parallel group trial per CONSORT guidelines was conducted among randomly selected 340 families with children aged 2-5 (+/-3 months) years in Chandigarh, India. PLUMS was implemented at the family level with a focus on modifying the home media environment and targeted individual-level interventions using parent and child modules for 2 months. A post-intervention (immediately) and a follow-up assessment after 6 months was done. During the follow-up period, the interaction was done passively via WhatsApp groups. The control group received routine healthcare services. Validated and standardized tools, including a digital screen exposure questionnaire with a physical activity component, preschool child behavior checklist, and sleep disturbance scale for children, were used to collect data at baseline, post-intervention, and follow-up periods. The primary outcome was the mean difference in ST (minutes/day) among children in the intervention group versus the control group. Generalized estimating equation (GEE) analysis was performed to adjust for clustering. RESULTS: An equal number of families (n = 170) were randomly assigned to the intervention and control arms. In the post-intervention assessment, 161 and 166 families continued while, at the follow-up assessment, 154 and 147 were in the intervention and control arm, respectively. The mean difference in ST on a typical day [27.7 min, 95% Confidence Interval (CI) 5.1, 50.3] at the post-intervention assessment significantly (p < 0.05) decreased in the intervention (102.6 +/- 98.5 min) arm as compared with the control (130.3 +/- 112.8 min) arm. A significant reduction in ST (beta = -35.81 min, CI -70.6, -1.04) from baseline (beta = 123.1 min) to follow-up phase (beta = 116 min) was observed in GEE analysis. The duration of physical activity increased both at post-intervention (beta = 48.4 min, CI = +6.6, +90.3) and follow-up (beta = 73.4 min, CI = 36.2, 110.5) assessments in the intervention arm. CONCLUSION: The PLUMS intervention significantly reduced the children's mean ST on a typical day and increased the physical activity immediately post-intervention and during the 6-month follow-up period. These results might guide the policymakers to include strategies in the national child health programs in the Southeast Asia Region to reduce unwanted ST.Clinical trial registration: https://clinicaltrials.gov/, identifier CTRI/2017/09/009761. CI - Copyright (c) 2024 Kaur, Gupta, Chakrapani, Khan, Malhi, Kiran and Grover. FAU - Kaur, Nimran AU - Kaur N AD - Department of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. FAU - Gupta, Madhu AU - Gupta M AD - Department of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. FAU - Chakrapani, Venkatesan AU - Chakrapani V AD - Centre for Sexuality and Health Research and Policy (C-SHaRP), Chennai, India. FAU - Khan, Firoz AU - Khan F AD - Department of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. FAU - Malhi, Prahbhjot AU - Malhi P AD - Department of Pediatrics, PGIMER, Chandigarh, India. FAU - Kiran, Tanvi AU - Kiran T AD - Department of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. FAU - Grover, Sandeep AU - Grover S AD - Department of Psychiatry, PGIMER, Chandigarh, India. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20240618 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Child, Preschool MH - *Screen Time MH - Female MH - Male MH - India MH - Surveys and Questionnaires MH - Program Evaluation MH - Child Behavior MH - Television PMC - PMC11223730 OTO - NOTNLM OT - RCT OT - digital media OT - effectiveness OT - screen time OT - unwanted media screen COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/07/05 06:42 MHDA- 2024/07/05 06:43 PMCR- 2024/06/18 CRDT- 2024/07/05 04:13 PHST- 2023/09/30 00:00 [received] PHST- 2024/04/19 00:00 [accepted] PHST- 2024/07/05 06:43 [medline] PHST- 2024/07/05 06:42 [pubmed] PHST- 2024/07/05 04:13 [entrez] PHST- 2024/06/18 00:00 [pmc-release] AID - 10.3389/fpubh.2024.1304861 [doi] PST - epublish SO - Front Public Health. 2024 Jun 18;12:1304861. doi: 10.3389/fpubh.2024.1304861. eCollection 2024. PMID- 38966107 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240706 IS - 2516-5542 (Electronic) IS - 2516-5542 (Linking) VI - 7 IP - 1 DP - 2024 TI - Development of a questionnaire for assessing the impact of children's food marketing exposure on diet-related outcomes. PG - 174-182 LID - 10.1136/bmjnph-2024-000912 [doi] AB - INTRODUCTION: The Government of Thailand has drafted legislation to protect children from the harmful impact of unhealthy food (including beverages) marketing. Local evidence on Thai children's exposure to, and the impact of, this marketing is necessary to, first, support the adoption of this Law and, second, to contribute to assessing policy implementation and effectiveness. This study aimed to develop and validate a questionnaire for examining Thai children's exposure to unhealthy food marketing and its impact on diet-related outcomes. MATERIALS AND METHODS: To design the questionnaire, we first conceptualised the range of impacts of unhealthy food marketing on children's diet-related outcomes based on published frameworks. These outcomes related to food brand loyalty, preference, purchase and consumption. We conducted a literature review to gather related questions used in earlier surveys to assess these outcomes. Using these questions, we assessed content validity with five experts. Face validity and reliability were assessed for 32 children. Validity was assessed using Content Validity Index (CVI) and Kappa statistics. Reliability was assessed using Cronbach's alpha and intraclass correlation coefficients (ICC). RESULTS: We identified 15 survey questions that had been used to assess the outcomes of interest. The CVI of all questions was 1.0, indicating perfect agreement with each question's relevance by the experts. Most questions were perceived to be easy to read and comprehend, suggesting face validity. Cronbach's alpha and ICC of all questions were both 0.75, demonstrating internal consistency across responses to questions about, separately, brand loyalty, preferences, purchase and consumption. CONCLUSION: The final 15-item questionnaire provides a valid and reliable survey instrument for measuring the impact of unhealthy food marketing on children's diet-related outcomes. This instrument will be useful for gathering local evidence on the need for policy reform to protect children from unhealthy food marketing in Thailand. The instrument also provides a cost-effective approach for generating evidence in other jurisdictions to propel policy actions. This is a pilot study and the validity and reliability needs further testing after a larger-scale roll-out. CI - (c) Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Jindarattanaporn, Nongnuch AU - Jindarattanaporn N AUID- ORCID: 0000-0002-6241-7851 AD - Institute for Population and Social Research, Mahidol University, Nakhon Pathom, Thailand. FAU - Kelly, Bridget AU - Kelly B AD - Early Start, School of Health and Society, University of Wollongong, Wollongong, New South Wales, Australia. FAU - Punpuing, Sureeporn AU - Punpuing S AD - Institute for Population and Social Research, Mahidol University, Nakhon Pathom, Thailand. FAU - Phulkerd, Sirinya AU - Phulkerd S AUID- ORCID: 0000-0001-9373-3120 AD - Institute for Population and Social Research, Mahidol University, Nakhon Pathom, Thailand. LA - eng PT - Journal Article DEP - 20240604 PL - England TA - BMJ Nutr Prev Health JT - BMJ nutrition, prevention & health JID - 101769223 PMC - PMC11221310 OTO - NOTNLM OT - Dietary patterns OT - Nutrition assessment COIS- Competing interests: None declared. EDAT- 2024/07/05 06:42 MHDA- 2024/07/05 06:43 PMCR- 2024/06/04 CRDT- 2024/07/05 04:04 PHST- 2024/03/13 00:00 [received] PHST- 2024/05/14 00:00 [accepted] PHST- 2024/07/05 06:43 [medline] PHST- 2024/07/05 06:42 [pubmed] PHST- 2024/07/05 04:04 [entrez] PHST- 2024/06/04 00:00 [pmc-release] AID - bmjnph-2024-000912 [pii] AID - 10.1136/bmjnph-2024-000912 [doi] PST - epublish SO - BMJ Nutr Prev Health. 2024 Jun 4;7(1):174-182. doi: 10.1136/bmjnph-2024-000912. eCollection 2024. PMID- 38964222 OWN - NLM STAT- MEDLINE DCOM- 20240920 LR - 20250903 IS - 2213-1582 (Electronic) IS - 2213-1582 (Linking) VI - 43 DP - 2024 TI - Validation of fNIRS measurement of executive demand during walking with and without dual-task in younger and older adults and people with Parkinson's disease. PG - 103637 LID - S2213-1582(24)00076-7 [pii] LID - 10.1016/j.nicl.2024.103637 [doi] LID - 103637 AB - BACKGROUND: Walking with a concurrent cognitive task (dual-task walking) can pose a challenge to some populations due to aging or neurodegenerative disease. These tasks require cognitive resources involving the prefrontal cortex and can be studied using functional near-infrared spectroscopy (fNIRS). An important step in understanding fNIRS measures during such walking tasks is validating that measures reflect the demands of the tasks and not confounding sources or movement artifacts. AIM: This study aimed to investigate the validity of fNIRS measures of prefrontal cortex activity as an indicator of executive demand during usual walking (single-task) and dual-task walking against clinical and objective measures of motor behavior in young adults, older adults, and people with Parkinson's disease (PD), by evaluating several validation hypotheses. METHODS: In total, 133 participants were recruited from younger adults (18-50 years, n = 42), older adults (>/=60 years, n = 49) and people with PD (>/=60 years, n = 42). Activity in the prefrontal cortex during walking with and without an auditory Stroop task was measured with fNIRS. A combined hemoglobin measure (correlation-based signal improvement, CBSI) was calculated for use in a region of interest analysis in the dorsolateral prefrontal cortex (dlPFC). Pre-registered hypotheses regarding convergent validity, discriminant validity and known group validity were tested. An exploratory analysis of different hemoglobin measures was also performed. RESULTS: Increases in dlPFC activity were found from single- to dual-task walking in the younger adults group and from rest to single-task walking in the older adults and PD groups. In line with hypotheses, a positive relationship was found between between dlPFC activity during dual-task walking and dual-task cost in the younger adults group, as well as a positive relationship to step time variability during single-task walking and a negative relationship to walking speed during single-task walking in the PD group. However, several clinical and gait measures lacked a relationship with dlPFC activity. CONCLUSION: The fNIRS results point towards the CBSI measure of dlPFC activity being a valid measure of executive demand during both single and dual-task walking. Some relationships between clinical and gait measures and brain activity during walking need further investigation. CI - Copyright (c) 2024 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Kvist, Alexander AU - Kvist A AD - Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden. Electronic address: alexander.kvist@ki.se. FAU - Bezuidenhout, Lucian AU - Bezuidenhout L AD - Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden; Department of Health and Rehabilitation Sciences, Division of Physiotherapy, Stellenbosch University, Cape Town, South Africa. FAU - Johansson, Hanna AU - Johansson H AD - Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden; Women's Health and Allied Health Professionals Theme, Medical Unit Occupational Therapy & Physiotherapy, Karolinska University Hospital, Stockholm, Sweden; Stockholm Sjukhem Foundation, Mariebergsgatan 22, 112 19 Stockholm, Sweden. FAU - Albrecht, Franziska AU - Albrecht F AD - Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden; Women's Health and Allied Health Professionals Theme, Medical Unit Occupational Therapy & Physiotherapy, Karolinska University Hospital, Stockholm, Sweden. FAU - Moulaee Conradsson, David AU - Moulaee Conradsson D AD - Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden; Women's Health and Allied Health Professionals Theme, Medical Unit Occupational Therapy & Physiotherapy, Karolinska University Hospital, Stockholm, Sweden. FAU - Franzen, Erika AU - Franzen E AD - Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden; Women's Health and Allied Health Professionals Theme, Medical Unit Occupational Therapy & Physiotherapy, Karolinska University Hospital, Stockholm, Sweden; Stockholm Sjukhem Foundation, Mariebergsgatan 22, 112 19 Stockholm, Sweden. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20240701 PL - Netherlands TA - Neuroimage Clin JT - NeuroImage. Clinical JID - 101597070 SB - IM MH - Humans MH - *Spectroscopy, Near-Infrared/methods MH - Male MH - Female MH - Middle Aged MH - Adult MH - *Parkinson Disease/physiopathology/diagnostic imaging MH - Aged MH - *Executive Function/physiology MH - *Walking/physiology MH - Young Adult MH - *Prefrontal Cortex/physiopathology/diagnostic imaging MH - Adolescent MH - Stroop Test MH - Psychomotor Performance/physiology PMC - PMC11278929 OTO - NOTNLM OT - Dual-task walking OT - Gait OT - Parkinson OT - Validation OT - fNIRS COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/07/05 00:41 MHDA- 2024/09/20 11:30 PMCR- 2024/07/01 CRDT- 2024/07/04 18:09 PHST- 2024/03/18 00:00 [received] PHST- 2024/05/28 00:00 [revised] PHST- 2024/06/29 00:00 [accepted] PHST- 2024/09/20 11:30 [medline] PHST- 2024/07/05 00:41 [pubmed] PHST- 2024/07/04 18:09 [entrez] PHST- 2024/07/01 00:00 [pmc-release] AID - S2213-1582(24)00076-7 [pii] AID - 103637 [pii] AID - 10.1016/j.nicl.2024.103637 [doi] PST - ppublish SO - Neuroimage Clin. 2024;43:103637. doi: 10.1016/j.nicl.2024.103637. Epub 2024 Jul 1. PMID- 38962763 OWN - NLM STAT- MEDLINE DCOM- 20240704 LR - 20261027 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 12 DP - 2024 TI - Study on the relationship between body mass index and blood pressure indices in children aged 7-17 during COVID-19. PG - 1409214 LID - 10.3389/fpubh.2024.1409214 [doi] LID - 1409214 AB - BACKGROUND: To explore the relationship between body mass index (BMI), age, sex, and blood pressure (systolic blood pressure, SBP; diastolic blood pressure, DBP) in children during COVID-19, providing reference for the prevention and screening of hypertension in children. METHODS: This study adopted a large-scale cross-sectional design to investigate the association between BMI and blood pressure in 7-17-year-old students in City N, China, during COVID-19. Thirty-six primary and secondary schools in City N were sampled using a stratified cluster sampling method. A total of 11,433 students aged 7-17 years in City N, China, were selected for blood pressure (Diastolic blood pressure, DBP, Systolic blood pressure, SBP), height, and weight, Resting heart rate (RHR), chest circumference, measurements, and the study was written using the STROBE checklist. Data analysis was conducted using SPSS 26.0, calculating the mean and standard deviation of BMI and blood pressure for male and female students in different age groups. Regression analysis was employed to explore the impact of BMI, age, and sex on SBP and DBP, and predictive models were established. The model fit was evaluated using the model R(2). RESULTS: The study included 11,287 primary and secondary school students, comprising 5,649 boys and 5,638 girls. It was found that with increasing age, BMI and blood pressure of boys and girls generally increased. There were significant differences in blood pressure levels between boys and girls in different age groups. In regression models, LC, Age, BMI, and chest circumference show significant positive linear relationships with SBP and DBP in adolescents, while RHR exhibits a negative linear relationship with SBP. These factors were individually incorporated into a stratified regression model, significantly enhancing the model's explanatory power. After including factors such as Age, Gender, and BMI, the adjusted R(2) value showed a significant improvement, with Age and BMI identified as key predictive factors for SBP and DBP. The robustness and predictive accuracy of the model were further examined through K-fold cross-validation and independent sample validation methods. The validation results indicate that the model has a high accuracy and explanatory power in predicting blood pressure in children of different weight levels, especially among obese children, where the prediction accuracy is highest. CONCLUSION: During COVID-19, age, sex, and BMI significantly influence blood pressure in children aged 7-17 years, and predictive models for SBP and DBP were established. This model helps predict blood pressure in children and reduce the risk of cardiovascular diseases. Confirmation of factors such as sex, age, and BMI provide a basis for personalized health plans for children, especially during large-scale infectious diseases, providing guidance for addressing health challenges and promoting the health and well-being of children. CI - Copyright (c) 2024 Mao, Qian, Xiao, Xu, Zhou and Guo. FAU - Mao, SuJie AU - Mao S AD - Graduate Development, Harbin Sport University, Harbin, Heilongjiang, China. FAU - Qian, GuoPing AU - Qian G AD - Faculty of Sports Medicine, Gdansk University of Sport, Gdansk, Poland. FAU - Xiao, KaiWen AU - Xiao K AD - Discipline Development Office, Nanjing Sport Institute, Nanjing, Jiangsu, China. FAU - Xu, Hong AU - Xu H AD - College of Sports and Health, Sangmyung University, Seoul, Republic of Korea. FAU - Zhou, Hao AU - Zhou H AD - Teaching Evaluation Center, Nanjing Police University, Nanjing, Jiangsu, China. FAU - Guo, XiuJin AU - Guo X AD - Discipline Development Office, Nanjing Sport Institute, Nanjing, Jiangsu, China. LA - eng PT - Journal Article DEP - 20240619 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Adolescent MH - *Body Mass Index MH - *COVID-19 MH - Child MH - Male MH - Female MH - Cross-Sectional Studies MH - China/epidemiology MH - *Blood Pressure/physiology MH - Hypertension MH - Sex Factors MH - SARS-CoV-2 MH - Age Factors PMC - PMC11220196 OTO - NOTNLM OT - BMI OT - children OT - obesity OT - physical fitness OT - predictive model COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/07/04 06:42 MHDA- 2024/07/04 06:43 PMCR- 2024/06/19 CRDT- 2024/07/04 04:26 PHST- 2024/03/29 00:00 [received] PHST- 2024/05/27 00:00 [accepted] PHST- 2024/07/04 06:43 [medline] PHST- 2024/07/04 06:42 [pubmed] PHST- 2024/07/04 04:26 [entrez] PHST- 2024/06/19 00:00 [pmc-release] AID - 10.3389/fpubh.2024.1409214 [doi] PST - epublish SO - Front Public Health. 2024 Jun 19;12:1409214. doi: 10.3389/fpubh.2024.1409214. eCollection 2024. PMID- 38961562 OWN - NLM STAT- MEDLINE DCOM- 20241119 LR - 20260708 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 20 IP - 4 DP - 2024 Oct TI - Reliability of anthropometric measurements of a digi-board in comparison to an analog height board in Namibian children under 5 years. PG - e13677 LID - 10.1111/mcn.13677 [doi] LID - e13677 AB - Poor measurement quality has set back the utility of anthropometry in defining childhood malnutrition, prompting calls for alternative measurement techniques. This study aimed to assess the reliability of anthropometric measurements using a digital height board in comparison to an analog height board in Namibian children under 5 years of age. A cross-sectional, descriptive study was conducted (n = 425) between the age of 6 and 59 months, using anthropometric measurements of weight, height and mid-upper arm circumference. Two trained enumerators each collected four height measurements of each child: two using an analog height board and two using a digi-board. The repeated height measurements between and within the enumerators were used to determine intra- and interobserver reliability. Reliability of the digi-board was assessed using the technical error of measurement (TEM), relative TEM (%TEM), intraclass correlation and a Bland-Altman analysis to assess the agreement between the two methods. In all these assessments, the analog height board was considered as the gold standard and used for comparison. The digi-board showed superiority to the analog height board in terms of reliability (analog TEM = 0.22, digi-board TEM = 0.16). Although the digi-board has potential to improve child anthropometry, further clinical and large survey studies are needed to validate the used of this tool in routine population-based surveys. CI - (c) 2024 The Authors. Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Namene, Johanna AU - Namene J AUID- ORCID: 0000-0003-2013-4340 AD - School of Medicine, University of Namibia, Windhoek, Namibia. FAU - Hunter, Christian J AU - Hunter CJ AD - Clinical Care, Education and Research, Centre of Global Health Practice and Impact, Georgetown University, Washington, District of Columbia, USA. FAU - Hodgson, Shirley AU - Hodgson S AD - Department of Clinical Genetics, St. George's University of London, London, UK. AD - United Kingdom Charity Nutritional Education and Research for Namibia, London, UK. FAU - Hodgson, Humphrey AU - Hodgson H AD - United Kingdom Charity Nutritional Education and Research for Namibia, London, UK. AD - Institute of Liver and Digestive Health, Division of Medicine, University College London, London, UK. FAU - Misihairabgwi, Jane AU - Misihairabgwi J AD - School of Medicine, University of Namibia, Windhoek, Namibia. FAU - Huang, Shan AU - Huang S AD - Maternal, Child and Adolescent Health Program, Burnet Institute, Melbourne, Victoria, Australia. AD - Department of Public Health and Preventative Medicine, Monash University, Melbourne, Australia. FAU - Conkle, Joel AU - Conkle J AD - UNICEF Division of Data, Analytics, Planning and Monitoring, New York, New York, USA. LA - eng GR - 00119380/UNICEF/UNDP Namibia/ GR - United Kingdom Charity Nutritional Education and Research for Namibia/ PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240703 PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - Child, Preschool MH - *Anthropometry/methods MH - Infant MH - Reproducibility of Results MH - Cross-Sectional Studies MH - *Body Height MH - Female MH - Male MH - *Body Weight MH - Namibia MH - Arm/anatomy & histology PMC - PMC11574652 OTO - NOTNLM OT - analog OT - anthropometry OT - children OT - digital OT - malnutrition OT - measurement OT - reliability COIS- The authors declare no conflict of interest. EDAT- 2024/07/04 06:42 MHDA- 2024/11/19 15:15 PMCR- 2024/07/03 CRDT- 2024/07/04 00:44 PHST- 2024/04/14 00:00 [revised] PHST- 2024/01/03 00:00 [received] PHST- 2024/05/22 00:00 [accepted] PHST- 2024/11/19 15:15 [medline] PHST- 2024/07/04 06:42 [pubmed] PHST- 2024/07/04 00:44 [entrez] PHST- 2024/07/03 00:00 [pmc-release] AID - MCN13677 [pii] AID - 10.1111/mcn.13677 [doi] PST - ppublish SO - Matern Child Nutr. 2024 Oct;20(4):e13677. doi: 10.1111/mcn.13677. Epub 2024 Jul 3. PMID- 38961346 OWN - NLM STAT- MEDLINE DCOM- 20240704 LR - 20250128 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 Jul 3 TI - Measurement properties of the Regular Physical Exercise Adherence Scale (REPEAS) in individuals with chronic pain. PG - 1776 LID - 10.1186/s12889-024-19297-w [doi] LID - 1776 AB - OBJECTIVE: To examine the measurement properties of the Regular Physical Exercise Adherence Scale (REPEAS) in Brazilians with chronic pain. METHODS: Cross-sectional and longitudinal design (washout period for reliability). The study was conducted in two Brazilian states, Maranhao and Sao Paulo, and included Brazilian adults, irregular exercisers, former exercisers or non-exercise practitioners, aged 18 to 59 years and with chronic pain. The instruments used in this study were: the REPEAS, the Numerical Pain Rating Scale (NPRS), the Baecke Habitual Physical Activity Questionnaire (BHPAQ), the Pain Self-Efficacy Questionnaire (PSEQ), and the Roland-Morris Disability Questionnaire for general pain (RMDQ-g). The evaluation focused on structural validity, construct validity, reliability (with standard error of measurement and minimum detectable change), internal consistency, and floor and ceiling effects. RESULTS: The two-dimensional structure was tested through confirmatory factor analysis, which resulted in adequate fit indeces: chi-square values/degrees of freedom = 1.541, Tucker-Lewis Index = 0.966, comparative fit index = 0.974, root mean square error of approximation = 0.074, and standardized root mean square residual = 0.068. Additionally, satisfactory factor loadings (> 0.40) were obtained. Test-retest reliability and internal consistency were adequate for the environmental factors domain (intraclass correlation coefficient [ICC] = 0.79, Cronbach's alpha = 0.88) and the personal factors domain (ICC = 0.97, Cronbach's alpha = 0.93). In hypothesis testing for construct validity, we observed a significant correlation with magnitude below 0.30 of the environmental factors domain of the REPEAS with RMDQ-g, PSEQ and sport domain of the BHPAQ. For the personal factors domain, we observed a significant correlation with a magnitude of 0.30 to 0.50 with RMDQ-g, PSEQ, and sport domain of the BHPAQ, and below 0.30 with leisure domain of the BHPAQ. No floor or ceiling effects were found for the REPEAS domains. CONCLUSION: The REPEAS is a valid instrument with a two-dimensional internal structure consisting of 12 items. It has a reliable construct and is suitable for use in the clinical and epidemiological context for adults with chronic pain in Brazil. CI - (c) 2024. The Author(s). FAU - Pinheiro, Cezar Augusto Brito AU - Pinheiro CAB AUID- ORCID: 0000-0002-2692-7854 AD - Postgraduate Program in Adult Health, Universidade Federal do Maranhao, Sao Luis, MA, Brazil. FAU - Bassi-Dibai, Daniela AU - Bassi-Dibai D AUID- ORCID: 0000-0002-6140-0177 AD - Postgraduate Program in Environment, Universidade Ceuma, Sao Luis, MA, Brazil. FAU - Pontes-Silva, Andre AU - Pontes-Silva A AUID- ORCID: 0000-0002-3983-5342 AD - Postgraduate Program in Physical Therapy, Department of Physical Therapy, Universidade Federal de Sao Carlos, Sao Carlos, SP, Brazil. contato.andrepsilva@gmail.com. FAU - Pereira, Fabio Henrique Ferreira AU - Pereira FHF AUID- ORCID: 0000-0003-4734-003X AD - Postgraduate Program in Environment, Universidade Ceuma, Sao Luis, MA, Brazil. FAU - Pinheiro, Jocassia Silva AU - Pinheiro JS AUID- ORCID: 0000-0003-4765-9024 AD - Postgraduate Program in Rehabilitation and Functional Performance, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil. FAU - Fidelis-de-Paula-Gomes, Cid Andre AU - Fidelis-de-Paula-Gomes CA AUID- ORCID: 0000-0001-6627-7537 AD - Postgraduate Program in Rehabilitation Science, Universidade Nove de Julho, Sao Paulo, SP, Brazil. FAU - Dibai-Filho, Almir Vieira AU - Dibai-Filho AV AUID- ORCID: 0000-0001-5403-8248 AD - Postgraduate Program in Adult Health, Universidade Federal do Maranhao, Sao Luis, MA, Brazil. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240703 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - *Chronic Pain/psychology MH - Adult MH - Female MH - Male MH - Middle Aged MH - *Exercise/psychology MH - Brazil MH - Cross-Sectional Studies MH - Adolescent MH - Young Adult MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - Longitudinal Studies MH - Patient Compliance/statistics & numerical data/psychology MH - Pain Measurement MH - Psychometrics MH - Factor Analysis, Statistical PMC - PMC11223431 OTO - NOTNLM OT - Chonic pain OT - Exercise OT - Public health OT - Sedentary behavior COIS- Cid Andre Fidelis de Paula Gomes, Almir Vieira Dibai-Filho, and Andre Pontes-Silva serve as Associate Editors and Reviewers for BMC Series. The remaining authors have no conflicts of interest. EDAT- 2024/07/04 00:42 MHDA- 2024/07/04 00:43 PMCR- 2024/07/03 CRDT- 2024/07/03 23:44 PHST- 2024/02/29 00:00 [received] PHST- 2024/06/27 00:00 [accepted] PHST- 2024/07/04 00:43 [medline] PHST- 2024/07/04 00:42 [pubmed] PHST- 2024/07/03 23:44 [entrez] PHST- 2024/07/03 00:00 [pmc-release] AID - 10.1186/s12889-024-19297-w [pii] AID - 19297 [pii] AID - 10.1186/s12889-024-19297-w [doi] PST - epublish SO - BMC Public Health. 2024 Jul 3;24(1):1776. doi: 10.1186/s12889-024-19297-w. PMID- 38961253 OWN - NLM STAT- MEDLINE DCOM- 20240704 LR - 20240706 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Jul 3 TI - Protein and fat intake impact on growth of primary school girls in Kerman, Iran. PG - 15288 LID - 10.1038/s41598-024-66001-4 [doi] LID - 15288 AB - The school age period is characterized by significant physical and intellectual growth, necessitating the monitoring of macronutrient intake and its impact on weight and height. The objective of this study is to investigate the association between the quality and quantity of protein and fat consumption with anthropometric indices in primary school girls in Kerman. This cross-sectional analysis was conducted on primary school girls aged 6-12 (n 330) from ten schools in Kerman, Iran. A validated and reliable dish-based 185-item food frequency questionnaire was used. We calculated the amount of proteins and fats as the percentage of daily calories and grams per day. Plant-based and animal-based proteins were used to assess the protein quality. To assess the fat quality, we considered trans fatty acids (TFA), cholesterol, vegetable oils, solid vegetable oils, animal oils, omega-6 Polyunsaturated fatty acids (PUFAs), omega-3 PUFA, and (PUFAs + Monounsaturated fatty acids (MUFAs))/Saturated fatty acids (SFAs), PUFAs/SFA, and (MUFA + PUFA)/(SFA + TFA). There was a significant positive association between height-for-age z-score (HAZ) and plant protein (p < 0.001) and vegetable oils (p = 0.038) after adjustment. In higher tertiles of animal protein, weight-for-age z-score (WAZ) (p = 0.024) were significantly higher. A significant positive association was observed between omega-3 PUFA and mid-upper arm circumference (MUAC) (p = 0.039) and BMI-for-age z-score (BAZ) (p = 0.016). Our study emphasizes the importance of monitoring protein and fat intake in primary school girls for optimal growth. Positive associations were found between plant-based protein, vegetable oils and HAZ, as well as animal protein and WAZ, highlighting the impact of protein quality on growth indicators. CI - (c) 2024. The Author(s). FAU - Jannati, Nooshin AU - Jannati N AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. FAU - Mahmoodi, Mohammad Reza AU - Mahmoodi MR AD - Physiology Research Center, Institute of Neuropharmacology and Department of Nutrition, Faculty of Public Health, Kerman University of Medical Sciences, Kerman, Iran. mahmoodimr@yahoo.com. FAU - Azadbakht, Leila AU - Azadbakht L AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. azadbakhtleila@gmail.com. LA - eng PT - Journal Article DEP - 20240703 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Dietary Fats) RN - 0 (Dietary Proteins) SB - IM MH - Female MH - Iran MH - Humans MH - Child MH - Cross-Sectional Studies MH - *Dietary Fats/analysis MH - Schools MH - Dietary Proteins PMC - PMC11222480 OTO - NOTNLM OT - Anthropometric indices OT - Fat OT - Kerman OT - Protein OT - Quality OT - Quantity OT - Student COIS- The authors declare no competing interests. EDAT- 2024/07/04 00:43 MHDA- 2024/07/04 00:44 PMCR- 2024/07/03 CRDT- 2024/07/03 23:35 PHST- 2023/08/06 00:00 [received] PHST- 2024/06/26 00:00 [accepted] PHST- 2024/07/04 00:44 [medline] PHST- 2024/07/04 00:43 [pubmed] PHST- 2024/07/03 23:35 [entrez] PHST- 2024/07/03 00:00 [pmc-release] AID - 10.1038/s41598-024-66001-4 [pii] AID - 66001 [pii] AID - 10.1038/s41598-024-66001-4 [doi] PST - epublish SO - Sci Rep. 2024 Jul 3;14(1):15288. doi: 10.1038/s41598-024-66001-4. PMID- 38958350 OWN - NLM STAT- MEDLINE DCOM- 20250423 LR - 20260616 IS - 2047-2927 (Electronic) IS - 2047-2919 (Print) IS - 2047-2919 (Linking) VI - 13 IP - 3 DP - 2025 Mar TI - Testosterone levels increase following bariatric surgery - validation of preceding literature in a large-scale population analysis. PG - 431-438 LID - 10.1111/andr.13689 [doi] AB - BACKGROUND: The effects of bariatric surgery on testosterone levels in men with obesity and hypogonadism have not been thoroughly explored yet. OBJECTIVES: To investigate the possible effects of bariatric surgery on T levels in obese hypogonadal men by comparing T levels before and after surgery using a comprehensive claims database. MATERIALS AND METHODS: The TriNetX US Collaborative Network database was used to identify men ages 18-80 who underwent a bariatric procedure and had a serum T value of < 350 ng/dL prior to surgery. Men who received testosterone therapy before/or after surgery were excluded. We conducted a retrospective self-matched cohort analysis to examine the difference in serum T levels before and after bariatric surgery. A sub-analysis was carried out to explore differences between men who reached eugonadal status or maintained low T levels following surgery. Descriptive statistics detailed sociodemographic and clinical characteristics, with continuous and categorical data compared using unpaired t-tests and chi-square analysis, respectively. Changes in T levels and body mass index (BMI) before and after surgery were compared using an unpaired t-test with a < 0.05 set for significance. All analyses were conducted using the TriNetX platform which utilizes both Python and R software. RESULTS: The study analyzed 69 hypogonadal men who underwent bariatric surgery and had T levels assessed before and after the procedure. The mean (standard deviation) pre-surgery serum T level was 208 +/- 79 ng/dL, which post-surgery increased to 371 +/- 164 ng/dL, marking an average increase of 163 +/- 164 ng/dL. Likewise, the mean (standard deviation) body mass index decreased from 42.9 +/- 9.0 to 38.8 +/- 5.7 kg/m(2). Post-surgery, 45% (31 men) achieved eugonadal status, while 55% (38 men) continued to have low T levels. A comparison between the post-surgery eugonadal cohort and the persistent low T cohort revealed that the former had higher pre-surgery serum T levels (235 +/- 71 ng/dL vs. 184 +/- 80.4 ng/dL, p = 0.007), a higher pre-surgery body mass index (45.5 +/- 4.5 kg/m(2) vs. 41.1 +/- 11.5 kg/m(2), p = 0.041), and a significantly greater reduction in body mass index post-surgery (7.3 +/- 7.2 kg/m(2) vs. 2.0 +/- 12.8 kg/m(2), p = 0.04). Notably, the increase in T was significantly higher in the eugonadal cohort compared to the persistent low testosterone cohort (257 +/- 143 ng/dL vs. 95 +/- 178 ng/dL, p < 0.0001). CONCLUSION: This study provides evidence of bariatric surgery's positive effect on serum T levels in obese men with baseline low T. Almost one out of two men with low T reached normal T levels after bariatric surgery. As the most comprehensive study to date, it validates and substantiates previous work suggesting that weight loss can improve T levels physiologically. CI - (c) 2024 The Author(s). Andrology published by Wiley Periodicals LLC on behalf of American Society of Andrology and European Academy of Andrology. FAU - Pozzi, Edoardo AU - Pozzi E AD - Desai Sethi Urology Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA. AD - Department of Urology, Vita-Salute San Raffaele University, Milan, Italy. AD - Urology, IRCCS Ospedale San Raffaele, Milan, Italy. FAU - Able, Corey A AU - Able CA AD - Department of Surgery, Division of Urology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA. FAU - Kohn, Taylor P AU - Kohn TP AD - The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA. FAU - Salonia, Andrea AU - Salonia A AUID- ORCID: 0000-0002-0595-7165 AD - Department of Urology, Vita-Salute San Raffaele University, Milan, Italy. AD - Urology, IRCCS Ospedale San Raffaele, Milan, Italy. FAU - Ramasamy, Ranjith AU - Ramasamy R AUID- ORCID: 0000-0003-1387-7904 AD - Desai Sethi Urology Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA. LA - eng PT - Journal Article PT - Validation Study DEP - 20240703 PL - England TA - Andrology JT - Andrology JID - 101585129 RN - 3XMK78S47O (Testosterone) SB - IM MH - Humans MH - Male MH - *Testosterone/blood MH - Adult MH - Middle Aged MH - *Bariatric Surgery MH - Retrospective Studies MH - *Hypogonadism/blood/complications MH - Aged MH - Young Adult MH - *Obesity/surgery/blood/complications MH - Adolescent MH - Body Mass Index MH - Aged, 80 and over PMC - PMC11867915 OTO - NOTNLM OT - bariatric surgery OT - epidemiology OT - obesity OT - testosterone COIS- The authors declare no conflict of interest. EDAT- 2024/07/03 13:19 MHDA- 2025/02/28 00:20 PMCR- 2025/02/28 CRDT- 2024/07/03 08:13 PHST- 2024/03/15 00:00 [received] PHST- 2024/06/22 00:00 [accepted] PHST- 2025/02/28 00:20 [medline] PHST- 2024/07/03 13:19 [pubmed] PHST- 2024/07/03 08:13 [entrez] PHST- 2025/02/28 00:00 [pmc-release] AID - ANDR13689 [pii] AID - 10.1111/andr.13689 [doi] PST - ppublish SO - Andrology. 2025 Mar;13(3):431-438. doi: 10.1111/andr.13689. Epub 2024 Jul 3. PMID- 38956887 OWN - NLM STAT- MEDLINE DCOM- 20240902 LR - 20260420 IS - 1467-789X (Electronic) IS - 1467-7881 (Linking) VI - 25 IP - 10 DP - 2024 Oct TI - Association between ultraprocessed food consumption and excess adiposity in children and adolescents: A systematic review. PG - e13796 LID - 10.1111/obr.13796 [doi] AB - Ultraprocessed foods (UPF) consumption is associated with excess adiposity in adults, but this linkage remains unclear among children and adolescents. The present systematic review sought to address this research gap. Publications up to November 2023 were retrieved from PubMed, Web of Science, and Scopus databases. Outcomes included overweight/obesity anthropometric and body composition indicators; the exposure was UPF consumption based on the NOVA classification system. The review included 23 studies (i.e., 8 cohort and 15 cross-sectional); approximately half were carried out in Brazil. Inconclusive and heterogeneous evidence exists as few cohort studies found positive/mixed associations between UPF consumption and excess adiposity in pediatric populations, whereas most cross-sectional studies reported null associations. Such inconsistencies may be attributed to underlying methodological issues, especially heterogeneity in the outcomes assessed and UPF consumption operationalization and/or categorization. Future studies should adopt longitudinal designs with sufficiently extended follow-up periods, account for relevant confounding factors, employ validated and standardized measurement tools to assess dietary exposure, ensure consistent operationalization of variables, and encompass diverse geographic contexts. Ultimately, strengthening the quality of existing research evidence may better inform current and forthcoming policy and practice interventions aimed at mitigating the increasing prevalence of overweight/obesity in childhood and across the life course. CI - (c) 2024 The Author(s). Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation. FAU - Robles, Brenda AU - Robles B AUID- ORCID: 0000-0001-6023-7809 AD - Department of Economics, University of Rovira i Virgili, Reus, Spain. AD - Research Group on Statistics, Econometrics and Health (GRECS), University of Girona, Girona, Spain. AD - Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. FAU - Mota-Bertran, Anna AU - Mota-Bertran A AUID- ORCID: 0000-0002-7580-6127 AD - Research Group on Statistics, Econometrics and Health (GRECS), University of Girona, Girona, Spain. AD - Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. FAU - Saez, Marc AU - Saez M AD - Research Group on Statistics, Econometrics and Health (GRECS), University of Girona, Girona, Spain. AD - Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. FAU - Solans, Marta AU - Solans M AD - Research Group on Statistics, Econometrics and Health (GRECS), University of Girona, Girona, Spain. AD - Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. LA - eng PT - Journal Article PT - Systematic Review DEP - 20240702 PL - England TA - Obes Rev JT - Obesity reviews : an official journal of the International Association for the Study of Obesity JID - 100897395 SB - IM MH - Adolescent MH - Child MH - Humans MH - *Adiposity MH - Diet/adverse effects MH - Fast Foods/adverse effects MH - Food Handling MH - *Pediatric Obesity/epidemiology/etiology MH - *Food, Processed OTO - NOTNLM OT - NOVA OT - overweight/obesity OT - pediatric populations OT - ultraprocessed foods EDAT- 2024/07/03 06:42 MHDA- 2024/09/02 08:45 CRDT- 2024/07/03 01:43 PHST- 2023/12/17 00:00 [revised] PHST- 2023/07/28 00:00 [received] PHST- 2024/06/12 00:00 [accepted] PHST- 2024/09/02 08:45 [medline] PHST- 2024/07/03 06:42 [pubmed] PHST- 2024/07/03 01:43 [entrez] AID - 10.1111/obr.13796 [doi] PST - ppublish SO - Obes Rev. 2024 Oct;25(10):e13796. doi: 10.1111/obr.13796. Epub 2024 Jul 2. PMID- 38955847 OWN - NLM STAT- MEDLINE DCOM- 20240813 LR - 20261010 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 183 IP - 9 DP - 2024 Sep TI - Acceleration index predicts efficacy of orthostatic training on postural orthostatic tachycardia syndrome in children. PG - 4029-4039 LID - 10.1007/s00431-024-05664-7 [doi] AB - The objective of this study was to examine the utility of the acceleration index observed in an electrocardiogram (ECG) for the prediction of the effectiveness of orthostatic training in pediatric patients diagnosed with postural orthostatic tachycardia syndrome (POTS). This investigation focused on children diagnosed with POTS and undergoing orthostatic training at the Department of Pediatrics of Peking University First Hospital from January 2012 to October 2022. Specifically, patients hospitalized from January 2012 to December 2019 were included in the training set (54 cases), while those hospitalized from January 2020 to October 2022 were included in the external validation set (37 cases). All children received a 3-month orthostatic training, and the baseline symptom score (SS) was calculated in agreement with the pretreatment orthostatic intolerance symptom frequency. Additionally, we determined post-treatment SS during follow-up via telephone after the 3-month treatment. Children with a decrease in post-treatment SS by >/= 50% of the baseline were considered as responders; otherwise, they were considered as non-responders. Demographic data (age, sex, and body mass index), hemodynamic parameters (supine blood pressure, time to achieve a positive standing test, maximum increase in heart rate during the standing test, maximal heart rate reached during the standing test, and blood pressure at the point of maximal heart rate during the standing test), and electrocardiographic parameters (RR interval in the supine position, shortest RR interval in the upright position, and acceleration index) were collected from all the children prior to treatment. Univariate and multivariate regression analysis were conducted to investigate factors associated with the efficacy of orthostatic training. The predictive value of these indicators for the therapeutic effectiveness of orthostatic training in children with POTS was evaluated using receiver operating characteristic (ROC) analysis, and the indicators were validated using the validation set. Among the 54 children in the training set, 28 responded to orthostatic training, and 26 were nonresponsive. Compared with the non-responders, the responders demonstrated a significant reduction in acceleration index (P < 0.01). The ROC curve for the predictive value of the acceleration index exhibited an area under the curve = 0.81 (95% confidence interval: 0.685-0.926). With the acceleration index threshold < 27.93%, the sensitivity and specificity in the prediction of orthostatic training efficacy among children with POTS were 85.7% and 69.2%, respectively. The external validation results demonstrated that using acceleration index < 27.93% as the threshold, the sensitivity, specificity, and accuracy of predicting orthostatic training efficacy among children with POTS were 89.5%, 77.8%, and 83.8%, respectively. CONCLUSIONS: Electrocardiographic acceleration index can be used to predict the effectiveness of orthostatic training in treating children with POTS. WHAT IS KNOWN: * Postural orthostatic tachycardia syndrome (POTS) is a chronic orthostatic intolerance involving multiple mechanisms. Autonomic dysfunction is one of the main mechanisms of POTS in children and could be treated with orthostatic training. * In order to improve the efficacy of orthostatic training in children with POTS, it is particularly important to identify the patients with autonomic dysfunction as the main mechanism before the treatment. WHAT IS NEW: * We found acceleration index of the electrocardiogram (ECG) can be used as a satisfactory index to predict the efficacy of orthostatic training in the treatment of POTS in children. * Using the acceleration index to predict the efficacy of orthostatic training on POTS in children is easy to be popularized in hospitals at all levels because it is non-invasive, convenient, and not expensive. CI - (c) 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Xu, Bowen AU - Xu B AD - Department of Pediatrics, Peking University First Hospital, Beijing, China. AD - Department of Pediatrics, Beijing Children's Hospital, Beijing, China. FAU - Gao, Yumeng AU - Gao Y AD - Department of Pediatrics, Peking University First Hospital, Beijing, China. FAU - Zhang, Qingyou AU - Zhang Q AD - Department of Pediatrics, Peking University First Hospital, Beijing, China. FAU - Liao, Ying AU - Liao Y AD - Department of Pediatrics, Peking University First Hospital, Beijing, China. liaoyingwww@163.com. FAU - Du, Junbao AU - Du J AD - Department of Pediatrics, Peking University First Hospital, Beijing, China. junbaodu1@126.com. AD - State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China. junbaodu1@126.com. FAU - Jin, Hongfang AU - Jin H AD - Department of Pediatrics, Peking University First Hospital, Beijing, China. jinhongfang51@126.com. AD - State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China. jinhongfang51@126.com. LA - eng GR - PKU2022LCXQ028/Clinical Medicine Plus X - Young Scholars Project/ GR - 2022CR59/National High-Level Hospital Clinical Research Funding (Multi-center Clinical Research Project of Peking University First Hospital)/ PT - Journal Article DEP - 20240702 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Postural Orthostatic Tachycardia Syndrome/therapy/physiopathology/diagnosis MH - Male MH - Female MH - Child MH - *Electrocardiography/methods MH - Treatment Outcome MH - Adolescent MH - Heart Rate/physiology MH - Acceleration MH - Retrospective Studies MH - Predictive Value of Tests OTO - NOTNLM OT - Adolescent OT - Dysautonomia OT - Electrocardiogram acceleration index OT - Orthostatic training OT - Pediatric EDAT- 2024/07/03 00:42 MHDA- 2024/08/13 12:42 CRDT- 2024/07/02 23:13 PHST- 2024/04/09 00:00 [received] PHST- 2024/06/21 00:00 [accepted] PHST- 2024/06/20 00:00 [revised] PHST- 2024/08/13 12:42 [medline] PHST- 2024/07/03 00:42 [pubmed] PHST- 2024/07/02 23:13 [entrez] AID - 10.1007/s00431-024-05664-7 [pii] AID - 10.1007/s00431-024-05664-7 [doi] PST - ppublish SO - Eur J Pediatr. 2024 Sep;183(9):4029-4039. doi: 10.1007/s00431-024-05664-7. Epub 2024 Jul 2. PMID- 38954879 OWN - NLM STAT- MEDLINE DCOM- 20240907 LR - 20260630 IS - 1532-2157 (Electronic) IS - 0748-7983 (Linking) VI - 50 IP - 9 DP - 2024 Sep TI - Stratifying risk of failure to achieve textbook outcomes among patients undergoing hepatectomy for hepatocellular carcinoma: A multicenter score validation study. PG - 108477 LID - S0748-7983(24)00529-8 [pii] LID - 10.1016/j.ejso.2024.108477 [doi] AB - BACKGROUND AND AIMS: The concept of textbook outcomes (TOs) has gained increased attention as a critical metric to assess the quality and success of outcomes following complex surgery. A simple yet effective scoring system was developed and validated to predict risk of not achieving textbook outcomes (non-TOs) following hepatectomy for hepatocellular carcinoma (HCC). METHODS: Using a multicenter prospectively collected database, risk factors associated with non-TO among patients who underwent hepatectomy for HCC were identified. A predictive scoring system based on factors identified from multivariate regression analysis was used to risk stratify patients relative to non-TO. The score was developed using 70 % of the overall cohort and validated in the remaining 30 %. RESULTS: Among 3681 patients, 1458 (39.6 %) failied to experience a TO. Based on the derivation cohort, obesity, American Society of Anaesthesiologists score(ASA score), Child-Pugh grade, tumor size, and extent of hepatectomy were identified as independent predictors of non-TO. The scoring system ranged from 0 to 10 points. Patients were categorized into low (0-3 points), intermediate (4-6 points), and high risk (7-10 points) of non-TO. In the validation cohort, the predicted risk of developing non-TOs was 39.0 %, which closely matched the observed risk of 39.9 %. There were no differences among the predicted and observed risks within the different risk categories. CONCLUSIONS: A novel scoring system was able to predict risk of non-TO accurately following hepatectomy for HCC. The score may enable early identification of individuals at risk of adverse outcomes and inform surgical decision-making, and quality improvement initiatives. CI - Copyright (c) 2024 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved. FAU - Liu, Han AU - Liu H AD - Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, Changchun, Jilin, China. FAU - Diao, Yong-Kang AU - Diao YK AD - Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China. FAU - Wei, Feng AU - Wei F AD - Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, Changchun, Jilin, China. FAU - Wang, Si-Yuan AU - Wang SY AD - Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China. FAU - Liang, Ying-Jian AU - Liang YJ AD - Department of Hepatobiliary Surgery, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. FAU - Wu, Yi-Fan AU - Wu YF AD - Department of Hepatobiliary Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China. FAU - Zheng, Qi-Xuan AU - Zheng QX AD - Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China. FAU - Wang, Xian-Ming AU - Wang XM AD - Department of General Surgery, First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China. FAU - Wang, Hong AU - Wang H AD - Department of General Surgery, Liuyang People's Hospital, Liuyang, Hunan, China. FAU - Li, Jie AU - Li J AD - Department of Hepatobiliary Surgery, Fuyang People's Hospital, Fuyang, Anhui, China. FAU - Chen, Ting-Hao AU - Chen TH AD - Department of General Surgery, Ziyang First People's Hospital, Ziyang, Sichuan, China. FAU - Wu, Xiao-Chang AU - Wu XC AD - Department of Hepatobiliary Surgery, Huzhou Central Hospital, Zhejiang University Huzhou Hospital, Huzhou, Zhejiang, China. FAU - Gu, Wei-Min AU - Gu WM AD - The First Department of General Surgery, The Fourth Hospital of Harbin, Harbin, Heilongjiang, China. FAU - Zhou, Ya-Hao AU - Zhou YH AD - Department of Hepatobiliary Surgery, Pu'er People's Hospital, Pu'er, Yunnan, China. FAU - Guo, Hong-Wei AU - Guo HW AD - The 2nd Department of General Surgery, The Second People's Hospital of Changzhi, Changzhi, China. FAU - Shao, Guang-Zhao AU - Shao GZ AD - Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, Changchun, Jilin, China. FAU - Xu, Jia-Hao AU - Xu JH AD - Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China. FAU - Yao, Lan-Qing AU - Yao LQ AD - Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China. FAU - Wang, Ming-Da AU - Wang MD AD - Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China. FAU - Shen, Feng AU - Shen F AD - Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China. FAU - Pawlik, Timothy M AU - Pawlik TM AD - Department of Surgery, Ohio State University, Wexner Medical Center, Columbus, OH, United States. FAU - Lau, Wan Yee AU - Lau WY AD - Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China; Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China. FAU - Lv, Guo-Yue AU - Lv GY AD - Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, Changchun, Jilin, China. FAU - Yang, Tian AU - Yang T AD - Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, Changchun, Jilin, China; Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China. Electronic address: yangtianehbh@smmu.edu.cn. LA - eng PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20240611 PL - England TA - Eur J Surg Oncol JT - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology JID - 8504356 SB - IM MH - Humans MH - *Hepatectomy MH - *Carcinoma, Hepatocellular/surgery/pathology MH - *Liver Neoplasms/surgery/pathology MH - Female MH - Male MH - Middle Aged MH - Risk Assessment/methods MH - Aged MH - Risk Factors MH - Tumor Burden OTO - NOTNLM OT - Complications OT - Hepatectomy OT - Hepatocellular carcinoma OT - Risk prediction OT - Textbook outcome COIS- Declaration of competing interest Neither the entire manuscript nor any part of its content has been published or has been accepted elsewhere and this manuscript has not been submitted to any other journal. No portion of the text has been copied from other material in the literature. All of the authors in this manuscript have read and approved the final version submitted, and there are no conflicts involved in this submission. EDAT- 2024/07/03 00:42 MHDA- 2024/09/08 13:49 CRDT- 2024/07/02 18:02 PHST- 2024/05/26 00:00 [received] PHST- 2024/06/08 00:00 [accepted] PHST- 2024/09/08 13:49 [medline] PHST- 2024/07/03 00:42 [pubmed] PHST- 2024/07/02 18:02 [entrez] AID - S0748-7983(24)00529-8 [pii] AID - 10.1016/j.ejso.2024.108477 [doi] PST - ppublish SO - Eur J Surg Oncol. 2024 Sep;50(9):108477. doi: 10.1016/j.ejso.2024.108477. Epub 2024 Jun 11. PMID- 38954458 OWN - NLM STAT- MEDLINE DCOM- 20240702 LR - 20250801 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 13 DP - 2024 Jul 2 TI - Body Composition and Energy Expenditure in Youth With Spina Bifida: Protocol for a Multisite, Cross-Sectional Study. PG - e52779 LID - 10.2196/52779 [doi] LID - e52779 AB - BACKGROUND: Obesity prevalence in youth with spina bifida is higher than in their typically developing peers. Obesity is associated with lifelong medical, psychological, and economic burdens. Successful prevention or treatment of obesity in individuals with spina bifida is compromised by (1) the lack of valid and reliable methods to identify body fat in a clinical setting and (2) limited data on energy expenditure that are necessary to provide daily caloric recommendations. OBJECTIVE: The objectives of this study will be to develop 2 algorithms for use in youth with spina bifida in a clinical setting, one to model body fat and one to predict total daily energy expenditure. In addition, physical activity and dietary intake will be described for the sample. METHODS: This multisite, prospective, national clinical study will enroll 232 youth with myelomeningocele aged 5 to 18 years (stratified by age and mobility). Participants will be enrolled for 1 week. Data obtained include 4 measures of body composition, up to 5 height measures, a ramped activity protocol, and a nutrition and physical activity screener. Participants will wear an accelerometer for the week. On the final study day, 2 samples of urine or saliva, which complete the doubly labeled water protocol, will be obtained. The analysis will include descriptive statistics, Bland-Altman plots, concordance correlation, and regression analysis. RESULTS: The study received extramural federal funding in July 2019. Data collection was initiated in March 2020. As of April 2024, a total of 143 (female participants: n=76, 53.1%; male participants: n=67, 46.9%) out of 232 participants have been enrolled. Data collection is expected to continue throughout 2024. A no-cost extension until November 2025 will be requested for data analysis and dissemination of findings. CONCLUSIONS: This study furthers previous pilot work that confirmed the acceptability and feasibility of obtaining alternate height, body composition, and energy expenditure measures. The findings from this study will enhance screening, prevention, and treatment of abnormal weight status by facilitating the accurate identification of youths' weight status category and recommendations of daily caloric needs for this population that is at higher risk of obesity. Furthermore, the findings have the potential to impact outcomes for youth diagnosed with disabilities other than spina bifida who experience similar challenges related to alterations in body composition or fat distribution or measurement challenges secondary to mobility issues or musculoskeletal problems. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/52779. CI - (c)Michele Polfuss, Kathryn Smith, Betsy Hopson, Andrea Moosreiner, Chiang-Ching Huang, Michele N Ravelli, Dan Ding, Zijian Huang, Brandon G Rocque, Rosemary White-Traut, Alexander Van Speybroeck, Kathleen J Sawin. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 02.07.2024. FAU - Polfuss, Michele AU - Polfuss M AUID- ORCID: 0000-0001-6589-3282 AD - School of Nursing, College of Health Professions and Sciences, University of Wisconsin - Milwaukee, Milwaukee, WI, United States. AD - Department of Nursing Research and Evidence-Based Practice, Children's Wisconsin, Milwaukee, WI, United States. FAU - Smith, Kathryn AU - Smith K AUID- ORCID: 0000-0001-5135-1482 AD - Department of Pediatrics, USC Keck School of Medicine, Children's Hospital of Los Angeles, Los Angeles, CA, United States. FAU - Hopson, Betsy AU - Hopson B AUID- ORCID: 0000-0001-8217-1433 AD - Department of Mediciine, University of Alabama at Birmingham, Birmingham, AL, United States. FAU - Moosreiner, Andrea AU - Moosreiner A AUID- ORCID: 0000-0003-0629-1702 AD - Clinical and Translational Science Institute, Medical College of Wisconsin, Milwaukee, WI, United States. FAU - Huang, Chiang-Ching AU - Huang CC AUID- ORCID: 0000-0003-4251-9911 AD - Zilber College of Public Health, University of Wisconsin - Milwaukee, Milwaukee, WI, United States. FAU - Ravelli, Michele N AU - Ravelli MN AUID- ORCID: 0000-0003-3809-9483 AD - Biotechnology Center, University of Wisconsin - Madison, Madison, WI, United States. FAU - Ding, Dan AU - Ding D AUID- ORCID: 0000-0001-7044-7770 AD - Department of Rehabilitation Science and Technology, University of Pittsburgh, Pittsburgh, PA, United States. FAU - Huang, Zijian AU - Huang Z AUID- ORCID: 0009-0004-1731-8186 AD - Department of Rehabilitation Science and Technology, University of Pittsburgh, Pittsburgh, PA, United States. FAU - Rocque, Brandon G AU - Rocque BG AUID- ORCID: 0000-0002-7333-4808 AD - Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, United States. FAU - White-Traut, Rosemary AU - White-Traut R AUID- ORCID: 0000-0002-0731-346X AD - Department of Nursing Research and Evidence-Based Practice, Children's Wisconsin, Milwaukee, WI, United States. AD - College of Nursing, University of Illinois at Chicago, Chicago, IL, United States. FAU - Van Speybroeck, Alexander AU - Van Speybroeck A AUID- ORCID: 0000-0002-3910-1082 AD - Division of General Pediatrics, USC Keck School of Medicine, Children's Hospital of Los Angeles, Los Angeles, CA, United States. FAU - Sawin, Kathleen J AU - Sawin KJ AUID- ORCID: 0000-0003-2884-3248 AD - School of Nursing, College of Health Professions and Sciences, University of Wisconsin - Milwaukee, Milwaukee, WI, United States. AD - Department of Nursing Research and Evidence-Based Practice, Children's Wisconsin, Milwaukee, WI, United States. LA - eng GR - R01 HD096085/HD/NICHD NIH HHS/United States PT - Journal Article PT - Multicenter Study PT - Research Support, N.I.H., Extramural DEP - 20240702 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - Adolescent MH - Child MH - *Spinal Dysraphism/physiopathology MH - *Energy Metabolism/physiology MH - Cross-Sectional Studies MH - *Body Composition/physiology MH - Female MH - Male MH - Child, Preschool MH - Prospective Studies MH - Exercise PMC - PMC11252625 OTO - NOTNLM OT - adolescents OT - body composition OT - children OT - doubly labeled water OT - energy expenditure OT - obesity OT - overweight OT - spina bifida OT - wearable device COIS- Conflicts of Interest: None declared. EDAT- 2024/07/02 14:42 MHDA- 2024/07/02 21:42 PMCR- 2024/07/02 CRDT- 2024/07/02 11:53 PHST- 2023/09/14 00:00 [received] PHST- 2024/05/10 00:00 [accepted] PHST- 2024/05/09 00:00 [revised] PHST- 2024/07/02 21:42 [medline] PHST- 2024/07/02 14:42 [pubmed] PHST- 2024/07/02 11:53 [entrez] PHST- 2024/07/02 00:00 [pmc-release] AID - v13i1e52779 [pii] AID - 10.2196/52779 [doi] PST - epublish SO - JMIR Res Protoc. 2024 Jul 2;13:e52779. doi: 10.2196/52779. PMID- 38953637 OWN - NLM STAT- MEDLINE DCOM- 20240814 LR - 20260609 IS - 2150-7511 (Electronic) VI - 15 IP - 8 DP - 2024 Aug 14 TI - Infant and adult human intestinal enteroids are morphologically and functionally distinct. PG - e0131624 LID - 10.1128/mbio.01316-24 [doi] LID - e01316-24 AB - Human intestinal enteroids (HIEs) are gaining recognition as physiologically relevant models of the intestinal epithelium. While HIEs from adults are used extensively in biomedical research, few studies have used HIEs from infants. Considering the dramatic developmental changes that occur during infancy, it is important to establish models that represent infant intestinal characteristics and physiological responses. We established jejunal HIEs from infant surgical samples and performed comparisons to jejunal HIEs from adults using RNA sequencing (RNA-Seq) and morphologic analyses. We then validated differences in key pathways through functional studies and determined whether these cultures recapitulate known features of the infant intestinal epithelium. RNA-Seq analysis showed significant differences in the transcriptome of infant and adult HIEs, including differences in genes and pathways associated with cell differentiation and proliferation, tissue development, lipid metabolism, innate immunity, and biological adhesion. Validating these results, we observed a higher abundance of cells expressing specific enterocyte, goblet cell, and enteroendocrine cell markers in differentiated infant HIE monolayers, and greater numbers of proliferative cells in undifferentiated 3D cultures. Compared to adult HIEs, infant HIEs portray characteristics of an immature gastrointestinal epithelium including significantly shorter cell height, lower epithelial barrier integrity, and lower innate immune responses to infection with an oral poliovirus vaccine. HIEs established from infant intestinal tissues reflect characteristics of the infant gut and are distinct from adult cultures. Our data support the use of infant HIEs as an ex vivo model to advance studies of infant-specific diseases and drug discovery for this population. IMPORTANCE: Tissue or biopsy stem cell-derived human intestinal enteroids are increasingly recognized as physiologically relevant models of the human gastrointestinal epithelium. While enteroids from adults and fetal tissues have been extensively used for studying many infectious and non-infectious diseases, there are few reports on enteroids from infants. We show that infant enteroids exhibit both transcriptomic and morphological differences compared to adult cultures. They also differ in functional responses to barrier disruption and innate immune responses to infection, suggesting that infant and adult enteroids are distinct model systems. Considering the dramatic changes in body composition and physiology that begin during infancy, tools that appropriately reflect intestinal development and diseases are critical. Infant enteroids exhibit key features of the infant gastrointestinal epithelium. This study is significant in establishing infant enteroids as age-appropriate models for infant intestinal physiology, infant-specific diseases, and responses to pathogens. FAU - Adeniyi-Ipadeola, Grace O AU - Adeniyi-Ipadeola GO AUID- ORCID: 0000-0003-2076-414X AD - Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA. FAU - Hankins, Julia D AU - Hankins JD AD - Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA. FAU - Kambal, Amal AU - Kambal A AD - Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA. AD - Texas Medical Center Digestive Diseases Center Gastrointestinal Experimental Model Systems (GEMS) Core, Houston, Texas, USA. FAU - Zeng, Xi-Lei AU - Zeng X-L AD - Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA. AD - Texas Medical Center Digestive Diseases Center Gastrointestinal Experimental Model Systems (GEMS) Core, Houston, Texas, USA. FAU - Patil, Ketki AU - Patil K AD - Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA. FAU - Poplaski, Victoria AU - Poplaski V AD - Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA. FAU - Bomidi, Carolyn AU - Bomidi C AD - Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA. FAU - Nguyen-Phuc, Hoa AU - Nguyen-Phuc H AD - Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA. FAU - Grimm, Sandra L AU - Grimm SL AD - Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA. AD - Center for Precision and Environmental Health, Baylor College of Medicine, Houston, Texas, USA. FAU - Coarfa, Cristian AU - Coarfa C AD - Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA. AD - Center for Precision and Environmental Health, Baylor College of Medicine, Houston, Texas, USA. FAU - Stossi, Fabio AU - Stossi F AD - Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA. AD - Gulf Coast Consortium Center for Advanced Microscopy and Image Informatics, Houston, Texas, USA. FAU - Crawford, Sue E AU - Crawford SE AD - Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA. FAU - Blutt, Sarah E AU - Blutt SE AD - Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA. AD - Texas Medical Center Digestive Diseases Center Gastrointestinal Experimental Model Systems (GEMS) Core, Houston, Texas, USA. FAU - Speer, Allison L AU - Speer AL AD - Department of Pediatric Surgery, The University of Texas Health Science Center, Houston, Texas, USA. FAU - Estes, Mary K AU - Estes MK AUID- ORCID: 0000-0002-4813-4249 AD - Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA. AD - Texas Medical Center Digestive Diseases Center Gastrointestinal Experimental Model Systems (GEMS) Core, Houston, Texas, USA. AD - Department of Medicine, Baylor College of Medicine, Houston, Texas, USA. FAU - Ramani, Sasirekha AU - Ramani S AUID- ORCID: 0000-0001-5631-8534 AD - Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA. LA - eng SI - GEO/GSE227205 GR - P30 ES030285, P42 ES027725/HHS | NIH | National Institute of Environmental Health Sciences (NIEHS)/ GR - T32 GM136554/GM/NIGMS NIH HHS/United States GR - RP170005, RP210227, RP200504/Cancer Prevention and Research Institute of Texas (CPRIT)/ GR - U19 AI144297/AI/NIAID NIH HHS/United States GR - R21-A1132985, PO1-AI057788, AI144297, AI116497/HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID)/ GR - P42 ES027725/ES/NIEHS NIH HHS/United States GR - P30 DK056338/DK/NIDDK NIH HHS/United States GR - S10 OD030414/OD/NIH HHS/United States GR - T32GM136554/HHS | NIH | National Institute of General Medical Sciences (NIGMS)/ GR - S10 RR024574/RR/NCRR NIH HHS/United States GR - P50MD015496/HHS | NIH | National Institute on Minority Health and Health Disparities (NIMHD)/ GR - Research Starter Grant in Translational Medicine/Pharmaceutical Research and Manufacturers of America Foundation (PhRMAF)/ GR - K08 DK131326/DK/NIDDK NIH HHS/United States GR - U19 AI116497/AI/NIAID NIH HHS/United States GR - S10 OD028480/OD/NIH HHS/United States GR - P30 ES030285/ES/NIEHS NIH HHS/United States GR - P30 CA125123/CA/NCI NIH HHS/United States GR - DK056338, 1K08DK131326/HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/ GR - P50 MD015496/MD/NIMHD NIH HHS/United States GR - P01 AI057788/AI/NIAID NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, N.I.H., Intramural PT - Research Support, Non-U.S. Gov't DEP - 20240702 PL - United States TA - mBio JT - mBio JID - 101519231 SB - IM UOF - bioRxiv. 2024 Feb 17:2023.05.19.541350. doi: 10.1101/2023.05.19.541350. PMID: 37292968 MH - Humans MH - Infant MH - *Intestinal Mucosa/cytology/immunology MH - Adult MH - Cell Differentiation MH - Jejunum/cytology/immunology MH - Transcriptome MH - Organoids MH - Immunity, Innate MH - Female MH - Male MH - Infant, Newborn MH - Enterocytes PMC - PMC11323560 OTO - NOTNLM OT - development OT - enteroids OT - infant gut OT - intestinal organoids COIS- The authors declare no conflict of interest. EDAT- 2024/07/02 14:43 MHDA- 2024/08/14 12:42 PMCR- 2024/07/02 CRDT- 2024/07/02 09:03 PHST- 2024/08/14 12:42 [medline] PHST- 2024/07/02 14:43 [pubmed] PHST- 2024/07/02 09:03 [entrez] PHST- 2024/07/02 00:00 [pmc-release] AID - mbio01316-24 [pii] AID - mbio.01316-24 [pii] AID - 10.1128/mbio.01316-24 [doi] PST - ppublish SO - mBio. 2024 Aug 14;15(8):e0131624. doi: 10.1128/mbio.01316-24. Epub 2024 Jul 2. PMID- 38953588 OWN - NLM STAT- MEDLINE DCOM- 20251023 LR - 20260924 IS - 1476-8321 (Electronic) IS - 0887-0446 (Linking) VI - 40 IP - 11 DP - 2025 Nov TI - Development and psychometric assessment of the Sociocultural Influences on Exercise Behaviours in Adolescents Questionnaire. PG - 1919-1943 LID - 10.1080/08870446.2024.2372644 [doi] AB - OBJECTIVES: This research aimed to construct and psychometrically test a measure of multiple sociocultural dimensions (i.e. family, peers, media) theoretically associated with exercise behaviours/attitudes in adolescents; the Sociocultural Influences on Exercise Behaviours in Adolescents Questionnaire (SIEBAQ). METHODS AND MEASUREMENT: Part 1 of this study focused on measure construction and psychometric testing, involving item generation and exploratory factor analysis (EFA) to refine the item pool, with 905 adolescents (Mage 13.66 years (SD = 0.94); girls = 442). Part 2 sought to explore the convergent validity of the SIEBAQ (n = 846; n = 414 girls). RESULTS: EFA resulted in a 47-item measure with a nine-factor structure (including social media modelling, parent exercise expectations, peer co-participation; alpha = 0.72-0.92). Correlations revealed weak-moderate significant relationships between the SIEBAQ and related constructs (e.g. compulsive exercise, sociocultural attitudes towards appearance). Regression analyses with the SIEBAQ identified social media modelling of exercise as a significant predictor of compulsive exercise in boys and girls. Proving exercise ability to significant others also significantly predicted compulsive exercise outcomes. CONCLUSION: This newly developed measure holds promise. Further psychometric testing and validation of the SIEBAQ is the recommended next step to confirm the measure's nine-factor structure identified through EFA. FAU - Reynolds, Kalli A AU - Reynolds KA AD - School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK. FAU - Haycraft, Emma AU - Haycraft E AUID- ORCID: 0000-0002-7359-1759 AD - School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK. FAU - Plateau, Carolyn R AU - Plateau CR AUID- ORCID: 0000-0002-1256-1353 AD - School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240702 PL - England TA - Psychol Health JT - Psychology & health JID - 8807983 SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - Psychometrics MH - *Exercise/psychology MH - Surveys and Questionnaires/standards MH - *Adolescent Behavior/psychology MH - Factor Analysis, Statistical MH - Reproducibility of Results OTO - NOTNLM OT - adolescent OT - compulsive exercise OT - social media OT - sociocultural influence OT - teenager OT - young people EDAT- 2024/07/02 14:43 MHDA- 2025/10/23 06:27 CRDT- 2024/07/02 08:34 PHST- 2025/10/23 06:27 [medline] PHST- 2024/07/02 14:43 [pubmed] PHST- 2024/07/02 08:34 [entrez] AID - 10.1080/08870446.2024.2372644 [doi] PST - ppublish SO - Psychol Health. 2025 Nov;40(11):1919-1943. doi: 10.1080/08870446.2024.2372644. Epub 2024 Jul 2. PMID- 42518322 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2383-1219 (Electronic) IS - 2345-5152 (Print) IS - 2345-5152 (Linking) VI - 11 IP - 3 DP - 2024 Jul TI - Validity and Reliability of the Fundamental Motor Skills in Sports (FUS) Test for Iranian Children and Adolescents. PG - 157-169 LID - 10.30476/INTJSH.2024.101089.1368 [doi] AB - BACKGROUND: Confident and proficient participation in physical activities throughout life relies on mastering Fundamental Motor Skills. Given the need for more effective solutions in assessing fundamental basic skills in both children and adolescents, the present study aimed to evaluate the validity and reliability of the Fundamental Motor Skills test in sports (FUS) among Iranian children and adolescents. METHODS: This was a descriptive-correlation study with a cross-sectional design. A total number of 1500 children (750 girls and 750 boys) aged 7 to 14 with an average age of 10.63+/-2.54 were selected from eleven districts of Shiraz, Iran in the academic year of 2023-2024 through cluster sampling technique. For data collection, FUS test was used. The test was translated into Persian using an independent double-reverse translation method prior to its use. The content validity of the translated test was carefully verified and confirmed. Before testing each skill, the students were provided with a brief explanation about the importance and how to implement the skill. To analyze the data, Exploratory Factor Analysis (EFA), Confirmatory Factor Analysis (CFA), Pearson intraclass correlation coefficient, and One-sample t-test were employed. A significance level of alpha=0.05 was applied and the data were analyzed using SPSS version 23. RESULTS: The results of the confirmatory factor analysis indicated that all fit indices, except for Comparative Fit Index (GFI), exceed the threshold of 0.90. The results of the impact score revealed that all subscales achieved a score of 1.5 or higher, indicating satisfactory face validity. The results of the Content Validity Ratio (CVR) demonstrated that all subscales of the FUS test met or exceeded the threshold specified by the Lawshe Table (0.62). The results of the Content Validity Index (CVI) similarly revealed that all subscales of the FUS test attained a CVI score exceeding 0.79. Both inter-rater (0.96-0.97) and intra-rater (exceeding 0.96) reliability demonstrated considerable to nearly complete agreement. Detective agreements for FUS assignments ranged from 79.6% to 94.5%. A moderate positive correlation was noted between the Ball bouncing task and both the Forward roll (r=0.35; P=0.004) and Throwing & Catching tasks (r=0.39; P=0.002). Other relationships were either below average. Intraclass correlation coefficient (ICC) values, ranging between 0.93 and 0.98, affirm outstanding test-retest reliability. CONCLUSIONS: The results of our study demonstrated that the FUS test is both feasible and effective for use in school settings. Therefore, the FUS test holds promise in facilitating the enhancement of motor proficiency by offering a standardized and systematic means of evaluating Fundamental Motor Skills in school-age children and adults. CI - Copyright: (c) International Journal of School Health. FAU - Hossein Zamani, Mohammad AU - Hossein Zamani M AD - Department of Sport Sciences, Faculty of Human Sciences, Jahrom University, Jahrom, Iran. FAU - Hashemi, Ayoub AU - Hashemi A AD - Department of Sport Sciences, Faculty of Human Sciences, Yasouj University, Yasouj, Iran. FAU - Siavashi, Elahe AU - Siavashi E AD - Department of Sport Sciences, Faculty of Human Sciences, Yasouj University, Yasouj, Iran. FAU - Khanmohamadi, Razieh AU - Khanmohamadi R AD - Department of sports science, Faculty of Human Sciences, Urmia university, Urmia, Iran. FAU - Saeidi, Hamideh AU - Saeidi H AD - Bachelor of Physical Education and Sports Sciences, Islamic Azad University, Jahrom, Iran. LA - eng PT - Journal Article DEP - 20240701 PL - Iran TA - Int J Sch Health JT - International journal of school health JID - 101702483 PMC - PMC13342030 OTO - NOTNLM OT - Adolescent OT - Children OT - Face validity OT - Motor skills OT - Reliability and validity COIS- None declared. EDAT- 2024/07/01 00:00 MHDA- 2024/07/01 00:01 PMCR- 2024/07/01 CRDT- 2026/07/28 12:46 PHST- 2023/12/15 00:00 [received] PHST- 2024/01/22 00:00 [revised] PHST- 2024/04/28 00:00 [accepted] PHST- 2024/07/01 00:01 [medline] PHST- 2024/07/01 00:00 [pubmed] PHST- 2026/07/28 12:46 [entrez] PHST- 2024/07/01 00:00 [pmc-release] AID - intjsh-11-3 [pii] AID - 10.30476/INTJSH.2024.101089.1368 [doi] PST - epublish SO - Int J Sch Health. 2024 Jul 1;11(3):157-169. doi: 10.30476/INTJSH.2024.101089.1368. eCollection 2024 Jul. PMID- 38948974 OWN - NLM STAT- MEDLINE DCOM- 20240701 LR - 20241010 IS - 0030-9982 (Print) IS - 0030-9982 (Linking) VI - 74 IP - 6 DP - 2024 Jun TI - The risk of under-nutrition in hospitalised Malaysian children: Use of 3-minute nutrition screening-paediatrics (Paediatric 3-MinNS). PG - 1074-1078 LID - 10.47391/JPMA.9616 [doi] AB - OBJECTIVES: To evaluate the under-nutrition risk of children admitted to hospitals using a validated tool. METHODS: The cross-sectional study was conducted from September 2017 to June 2018 in the paediatrics wards of a tertiary referral paediatric government hospital, a tertiary teaching hospital and a government district hospital in Malaysia. The sample comprised paediatric patients aged 2-12 years within 24-72 hours of hospital admission. Data was collected using the 3-Minute Nutrition Screening-Paediatrics tool. Data was analysed using SPSS 20. RESULTS: Of the 341 patients screened, 284(83.3%) were included; 170(59.9%) boys and 114(40.1%) girls. The overall median age was 4.85 years (interquartile range: 4.33 years). The median length of hospital stay was 3 days (interquartile range: 3 days). There were 72(25.4%) participants at high under-nutrition risk, with the highest proportion being at the district government hospital 31(33%). Among those with high risk, 5.4% subjects had severe acute malnutrition, 9.7% had severe chronic malnutrition, and 11.1% had severe thinness. CONCLUSION: The 3-Minute Nutrition Screening-Paediatrics scale was found to be effective as a nutrition screening tool for hospitalised children in Malaysia. FAU - Yeo, Pei Sien AU - Yeo PS AD - Department of Social and Preventive Medicine, University of Malaya, Kuala Lumpur, Malaysia. FAU - Majid, Hazreen Abdul AU - Majid HA AD - School of Health and Rehabilitation Sciences, AECC University College, Bournemouth, United Kingdom. Centre for Population Health, Department of Social and Preventive Medicine, University of Malaya, Kuala Lumpur Malaysia. LA - eng PT - Journal Article PL - Pakistan TA - J Pak Med Assoc JT - JPMA. The Journal of the Pakistan Medical Association JID - 7501162 SB - IM MH - Humans MH - Female MH - Male MH - Malaysia/epidemiology MH - Child, Preschool MH - Child MH - Cross-Sectional Studies MH - *Nutrition Assessment MH - *Hospitalization/statistics & numerical data MH - Child Nutrition Disorders/epidemiology/diagnosis MH - Length of Stay/statistics & numerical data MH - Nutritional Status MH - Malnutrition/diagnosis/epidemiology MH - Mass Screening/methods/statistics & numerical data MH - Thinness/epidemiology MH - Risk Assessment/methods OTO - NOTNLM OT - Hospitalised children, Nutrition, Screening tool. EDAT- 2024/07/01 12:42 MHDA- 2024/07/01 12:43 CRDT- 2024/07/01 06:06 PHST- 2024/07/01 12:43 [medline] PHST- 2024/07/01 12:42 [pubmed] PHST- 2024/07/01 06:06 [entrez] AID - xxxx [pii] AID - 10.47391/JPMA.9616 [doi] PST - ppublish SO - J Pak Med Assoc. 2024 Jun;74(6):1074-1078. doi: 10.47391/JPMA.9616. PMID- 38948521 OWN - NLM STAT- MEDLINE DCOM- 20240701 LR - 20261016 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 15 DP - 2024 TI - Exploring the relationship between life course adiposity and sepsis: insights from a two-sample Mendelian randomization analysis. PG - 1413690 LID - 10.3389/fendo.2024.1413690 [doi] LID - 1413690 AB - OBJECTIVES: The relationship between adiposity and sepsis has received increasing attention. This study aims to explore the causal relationship between life course adiposity and the sepsis incidence. METHODS: Mendelian randomization (MR) method was employed in this study. Instrumental variants were obtained from genome-wide association studies for life course adiposity, including birth weight, childhood body mass index (BMI), childhood obesity, adult BMI, waist circumference, visceral adiposity, and body fat percentage. A meta-analysis of genome-wide association studies for sepsis including 10,154 cases and 454,764 controls was used in this study. MR analyses were performed using inverse variance weighted, MR Egger regression, weighted median, weighted mode, and simple mode. Instrumental variables were identified as significant single nucleotide polymorphisms at the genome-wide significance level (P < 5x10(-8)). The sensitivity analysis was conducted to assess the reliability of the MR estimates. RESULTS: Analysis using the MR analysis of inverse variance weighted method revealed that genetic predisposition to increased childhood BMI (OR = 1.29, P = 0.003), childhood obesity (OR = 1.07, P = 0.034), adult BMI (OR = 1.38, P < 0.001), adult waist circumference (OR = 1.01, P = 0.028), and adult visceral adiposity (OR = 1.53, P < 0.001) predicted a higher risk of sepsis. Sensitivity analysis did not identify any bias in the MR results. CONCLUSION: The results demonstrated that adiposity in childhood and adults had causal effects on sepsis incidence. However, more well-designed studies are still needed to validate their association. CI - Copyright (c) 2024 Cheng, Li, Tong, Liu, Zhang, Ma and Lu. FAU - Cheng, Zimei AU - Cheng Z AD - Department of Pediatric Intensive Care Unit, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China. FAU - Li, Jingjing AU - Li J AD - Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China. FAU - Tong, Wenjia AU - Tong W AD - Department of Pediatric Intensive Care Unit, Anhui Provincial Children's Hospital, Hefei, China. FAU - Liu, Tingyan AU - Liu T AD - Department of Pediatric Intensive Care Unit, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China. FAU - Zhang, Caiyan AU - Zhang C AD - Department of Pediatric Intensive Care Unit, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China. FAU - Ma, Jian AU - Ma J AD - Department of Pediatric Intensive Care Unit, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China. FAU - Lu, Guoping AU - Lu G AD - Department of Pediatric Intensive Care Unit, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China. AD - Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China. AD - Department of Pediatric Intensive Care Unit, Anhui Provincial Children's Hospital, Hefei, China. LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't DEP - 20240614 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - *Mendelian Randomization Analysis MH - *Adiposity/genetics MH - *Sepsis/genetics/epidemiology MH - *Genome-Wide Association Study MH - *Body Mass Index MH - *Polymorphism, Single Nucleotide MH - Genetic Predisposition to Disease MH - Pediatric Obesity/genetics/epidemiology/complications MH - Adult MH - Waist Circumference MH - Child MH - Male MH - Female PMC - PMC11211544 OTO - NOTNLM OT - abdominal OT - body mass index OT - fat body OT - obesity OT - obesity paradox OT - pediatric obesity OT - waist circumference COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/07/01 06:42 MHDA- 2024/07/01 12:42 PMCR- 2024/01/01 CRDT- 2024/07/01 05:57 PHST- 2024/04/07 00:00 [received] PHST- 2024/06/03 00:00 [accepted] PHST- 2024/07/01 12:42 [medline] PHST- 2024/07/01 06:42 [pubmed] PHST- 2024/07/01 05:57 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2024.1413690 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2024 Jun 14;15:1413690. doi: 10.3389/fendo.2024.1413690. eCollection 2024. PMID- 38947123 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240702 IS - 1728-869X (Print) IS - 2226-5104 (Electronic) IS - 1728-869X (Linking) VI - 22 IP - 4 DP - 2024 Oct TI - Psychometric property and measurement invariance of perceived benefits and barriers of physical activity in Chinese adolescents. PG - 322-328 LID - 10.1016/j.jesf.2024.05.002 [doi] AB - BACKGROUND: The perceived benefits and barriers to physical activity play crucial roles in determining daily physical activity levels. However, previous studies have employed tools lacking adequate validation, leading to inconsistent conclusions about the impact of these two factors. Therefore, this national, population-based study was conducted to assess the psychometric properties, measurement invariance, and predictive validity of the Chinese versions of the perceived benefits (C-PBEPA) and barriers to physical activity (C-PBAPA) scales. METHODS: The final sample (N = 2942, 49.3 % for boys) was randomly split into two subsamples. The first subsample was used for exploratory factor analysis and the second subsample was used for confirmatory factor analysis. Measurement invariance across gender and age groups were examined. Structural equation models were developed to examine the predictive validity of the revised C-PBEPA and C-PBAPA on moderate to vigorous PA. RESULTS: The results showed that both scales were unidimensional, had excellent model fit (e.g., X (2)/df < 3, CFI >0.9, RMSEA <0.06) and demonstrated convergent validity. Findings also revealed lack of scalar invariance for C-PBAPA between preadolescents and adolescents' groups (DeltaCFI >0.01) and supported the predictive validity of both scales (p < 0.001). CONCLUSION: The study demonstrated that the revised C-PBEPA and C-PBAPA are valid scales for measuring Chinese adolescents' perceived benefits and barriers to PA. CI - (c) 2024 The Society of Chinese Scholars on Exercise Physiology and Fitness. Published by Elsevier (Singapore) Pte Ltd. FAU - Dai, Jun AU - Dai J AD - Shanghai University of Sport, School of Physical Education, Shanghai, 200438, China. FAU - Chen, Han AU - Chen H AD - Valdosta State University, Department of Teacher Education KSPE, Valdosta, GA, 31698, USA. FAU - Sun, Haichun AU - Sun H AD - University of South Florida, College of Education, Tampa, FL, USA. LA - eng PT - Journal Article DEP - 20240530 PL - Singapore TA - J Exerc Sci Fit JT - Journal of exercise science and fitness JID - 101198241 PMC - PMC11214508 OTO - NOTNLM OT - Benefits and barriers of physical activity OT - Measurement invariance OT - Predictive validity OT - Psychometric property OT - Structural equation modeling COIS- The authors declare the following financial interests/personal relationships which may be considered as potential competing interests. Jun Dai reports financial support was provided by 10.13039/501100012456National Social Science Foundation of China. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/07/01 06:42 MHDA- 2024/07/01 06:43 PMCR- 2024/05/30 CRDT- 2024/07/01 05:39 PHST- 2023/12/14 00:00 [received] PHST- 2024/05/25 00:00 [revised] PHST- 2024/05/29 00:00 [accepted] PHST- 2024/07/01 06:43 [medline] PHST- 2024/07/01 06:42 [pubmed] PHST- 2024/07/01 05:39 [entrez] PHST- 2024/05/30 00:00 [pmc-release] AID - S1728-869X(24)00042-X [pii] AID - 10.1016/j.jesf.2024.05.002 [doi] PST - ppublish SO - J Exerc Sci Fit. 2024 Oct;22(4):322-328. doi: 10.1016/j.jesf.2024.05.002. Epub 2024 May 30. PMID- 38945368 OWN - NLM STAT- MEDLINE DCOM- 20240818 LR - 20260514 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 201 DP - 2024 Oct 1 TI - Adherence to mediterranean diet and aromatic plants intake are related with gustatory function: A case-study from a Portuguese region. PG - 107581 LID - S0195-6663(24)00384-2 [pii] LID - 10.1016/j.appet.2024.107581 [doi] AB - The Mediterranean Diet has been recognized as one of the healthiest and most sustainable dietary patterns and is flavor rich due to the use of different seasonings, such as aromatic plants, in dish confection. Based on the hypotheses that: 1) gustatory function will affect food choices; 2) seasoning flavors may be differently accepted according to individuals' gustatory functions; the aim of the present study was to assess the association between taste sensitivity and/or preference with Mediterranean Diet adherence and seasoning consumption. A total of 383 adults (18-59 years old; 198 female, 185 male) from North Alentejo region of Portugal were enrolled in this study, with 291 (145 female and 146 male) also evaluated for gustatory function. Recognition thresholds were obtained for four tastes (sweet, sour, salty, and bitter) and astringency, as well as preference level for the highest concentration of each stimulus tested. A validated Food Frequency Questionnaire was filled out, and MD adherence was extrapolated from the answers of the Food Frequency Questionnaire according to the Mediterranean Diet Adherence Screener (MEDAS) score. In total, 20.8% of the individuals presented low, 58.2% medium, and 21.0% high adherence. Adherence was higher in women than men and in older individuals than younger adults. Adherence to the Mediterranean Diet was positively correlated with aromatic plants consumption but not spices. Seasonings were associated with gustatory function, and the cluster with higher consumption presented higher preferences for bitter and salty tastes. Total sodium intake was also higher in this cluster, suggesting that these individuals prefer stronger oral sensations. In conclusion, this study shows that MD adherence is not high, even in regions with rural characteristics. The observed association of MD and seasoning intake with gustatory function do underline the usefulness of this information in strategies aimed at promoting healthy and sustainable eating patterns. CI - Copyright (c) 2024. Published by Elsevier Ltd. FAU - Louro, Teresa AU - Louro T AD - MED - Mediterranean Institute for Agriculture, Environment and Development & CHANGE - Global Change and Sustainability Institute, Institute for Advanced Studies and Research, Universidade de Evora, Polo da Mitra, Ap. 94, 7006-554, Evora, Portugal. FAU - Castelo, Paula Midori AU - Castelo PM AD - Department of Pharmaceutical Sciences, Universidade Federal de Sao Paulo (UNIFESP), Diadema, 09972-270, Brazil. FAU - Simoes, Carla AU - Simoes C AD - MED - Mediterranean Institute for Agriculture, Environment and Development & CHANGE - Global Change and Sustainability Institute, Institute for Advanced Studies and Research, Universidade de Evora, Polo da Mitra, Ap. 94, 7006-554, Evora, Portugal. FAU - Capela E Silva, Fernando AU - Capela E Silva F AD - MED - Mediterranean Institute for Agriculture, Environment and Development & CHANGE - Global Change and Sustainability Institute, Institute for Advanced Studies and Research, Universidade de Evora, Polo da Mitra, Ap. 94, 7006-554, Evora, Portugal; Department of Medical and Health Sciences, School of Health and Human Development, Universidade de Evora, Rua Romao Ramalho n masculine 59, 7000-671, Evora, Portugal. FAU - Luis, Henrique AU - Luis H AD - Oral and Biomedical Sciences Research Unit (UICOB), Faculdade de Medicina Dentaria, Universidade de Lisboa, 1600-277, Lisboa, Portugal; Center for Innovative Care and Health Technology (ciThecCare), Politecnico de Leiria, 2411-901, Leiria, Portugal. FAU - Moreira, Pedro AU - Moreira P AD - Faculty of Nutrition and Food Sciences, Universidade do Porto, 4150-180, Porto, Portugal. FAU - Lamy, Elsa AU - Lamy E AD - MED - Mediterranean Institute for Agriculture, Environment and Development & CHANGE - Global Change and Sustainability Institute, Institute for Advanced Studies and Research, Universidade de Evora, Polo da Mitra, Ap. 94, 7006-554, Evora, Portugal. Electronic address: ecsl@uevora.pt. LA - eng PT - Journal Article DEP - 20240628 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - Male MH - Adult MH - Portugal MH - *Diet, Mediterranean/statistics & numerical data MH - Middle Aged MH - Young Adult MH - Adolescent MH - *Food Preferences MH - *Taste MH - Patient Compliance/statistics & numerical data MH - Surveys and Questionnaires MH - Feeding Behavior/psychology MH - Taste Threshold/physiology OTO - NOTNLM OT - Alentejo OT - Aromatic plants OT - Gustatory function OT - Mediterranean diet OT - Portugal COIS- Declaration of competing interest The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. EDAT- 2024/07/01 00:42 MHDA- 2024/08/19 00:42 CRDT- 2024/06/30 19:26 PHST- 2024/04/01 00:00 [received] PHST- 2024/05/25 00:00 [revised] PHST- 2024/06/24 00:00 [accepted] PHST- 2024/08/19 00:42 [medline] PHST- 2024/07/01 00:42 [pubmed] PHST- 2024/06/30 19:26 [entrez] AID - S0195-6663(24)00384-2 [pii] AID - 10.1016/j.appet.2024.107581 [doi] PST - ppublish SO - Appetite. 2024 Oct 1;201:107581. doi: 10.1016/j.appet.2024.107581. Epub 2024 Jun 28. PMID- 38944402 OWN - NLM STAT- MEDLINE DCOM- 20240725 LR - 20240814 IS - 1878-5476 (Electronic) IS - 1878-5476 (Linking) VI - 74 DP - 2024 Sep TI - Perceived physical literacy in children and early adolescents: Two valid and reliable versions of the PL-C Quest. PG - 102694 LID - S1469-0292(24)00105-5 [pii] LID - 10.1016/j.psychsport.2024.102694 [doi] AB - Perceived physical literacy contributes to the understanding of individuals' physical activity (PA) engagement. It is important a scale is validated in the population of interest. Also, the type of administration may affect reliability and validity. So, the aim of this study was twofold: 1) to examine evidence of validity and reliability of the Spanish version of the Physical Literacy for Children Questionnaire (PL-C Quest) in a cohort of children and adolescents and 2) to assess two versions of administering the scale. The study was conducted in two stages, depending on the administration format of the PL-C Quest (double-dichotomous, and four-point response style) in a cohort of 2004 (n(1) = 916; n(2) = 1088) students. In both administration forms, evidence of validity (relation with other variables, i.e., concurrent and predictive, and structural validity), invariance (between boys and girls) and reliability (test-retest and internal consistency) were examined. There was evidence of validity for both administration types, with adequate reliability and good to excellent test-retest reliability for both administration forms. Both methods of administration for the PL-C Quest can capture perceived physical literacy in Spanish 8- to 14-year-old children and early adolescents. CI - Copyright (c) 2024. Published by Elsevier Ltd. FAU - Ortega-Benavent, Nuria AU - Ortega-Benavent N AD - AFIPS research group, University of Valencia, Avenida dels Tarongers, 4, 46022, Valencia, Spain; Department of Teaching of Physical Education, Arts and Music. University of Valencia, Avenida dels Tarongers, 4, 46022, Valencia, Spain. Electronic address: nuria.ortega-benavent@uv.es. FAU - Menescardi, Cristina AU - Menescardi C AD - AFIPS research group, University of Valencia, Avenida dels Tarongers, 4, 46022, Valencia, Spain; Department of Teaching of Physical Education, Arts and Music. University of Valencia, Avenida dels Tarongers, 4, 46022, Valencia, Spain. Electronic address: cristina.menescardi@uv.es. FAU - Romero-Martinez, Jorge AU - Romero-Martinez J AD - AFIPS research group, University of Valencia, Avenida dels Tarongers, 4, 46022, Valencia, Spain; Department of Teaching of Physical Education, Arts and Music. University of Valencia, Avenida dels Tarongers, 4, 46022, Valencia, Spain. Electronic address: jorge.romero-martinez@uv.es. FAU - Barnett, Lisa M AU - Barnett LM AD - Institute for Physical Activity and Nutrition, School of Health and Social Development, Deakin University, Locked Bag 20000, Geelong, VIC, 3220, Australia. Electronic address: lisa.barnett@deakin.edu.au. FAU - Estevan, Isaac AU - Estevan I AD - AFIPS research group, University of Valencia, Avenida dels Tarongers, 4, 46022, Valencia, Spain; Department of Teaching of Physical Education, Arts and Music. University of Valencia, Avenida dels Tarongers, 4, 46022, Valencia, Spain. Electronic address: isaac.estevan@uv.es. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20240627 PL - Netherlands TA - Psychol Sport Exerc JT - Psychology of sport and exercise JID - 101088724 SB - IM MH - Humans MH - Female MH - Male MH - Adolescent MH - Child MH - Reproducibility of Results MH - Surveys and Questionnaires MH - *Exercise MH - Health Literacy MH - Psychometrics/methods MH - Spain OTO - NOTNLM OT - Adolescence OT - Childhood OT - Motor development OT - Scale OT - Self-perception COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Isaac Estevan reports financial support was provided by Spanish National Research Agency, Ministry of Science and Innovation [PID 2020-115075RA-I00 by the MCIN/AEI/10.13039/5011000]. Nuria Ortega-Benavent reports financial support was provided by the Conselleria de Educacion, Universidades y Empleo [AICO/2022/185]. Jorge Romero-Martinez reports financial support was provided by Spanish Ministry of Universities [FPU21/03956 by the UNI/1504/2021]. The rest of authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/06/30 00:42 MHDA- 2024/07/26 12:40 CRDT- 2024/06/29 19:30 PHST- 2024/02/23 00:00 [received] PHST- 2024/04/26 00:00 [revised] PHST- 2024/06/26 00:00 [accepted] PHST- 2024/07/26 12:40 [medline] PHST- 2024/06/30 00:42 [pubmed] PHST- 2024/06/29 19:30 [entrez] AID - S1469-0292(24)00105-5 [pii] AID - 10.1016/j.psychsport.2024.102694 [doi] PST - ppublish SO - Psychol Sport Exerc. 2024 Sep;74:102694. doi: 10.1016/j.psychsport.2024.102694. Epub 2024 Jun 27. PMID- 38943131 OWN - NLM STAT- MEDLINE DCOM- 20240629 LR - 20250128 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 Jun 28 TI - Assessment of physical literacy in 8- to 12-year-old Pakistani school children: reliability and cross-validation of the Canadian assessment of physical literacy-2 (CAPL-2) in South Punjab, Pakistan. PG - 1726 LID - 10.1186/s12889-024-19185-3 [doi] LID - 1726 AB - BACKGROUND: The increasing prevalence of physical inactivity, declining fitness, and rising childhood obesity highlight the importance of physical literacy (PL), as a foundational component for fostering lifelong health and active lifestyle. This recognition necessitates the development of effective tools for PL assessment that are applicable across diverse cultural landscapes. AIM: This study aimed to translate the Canadian Assessment of Physical Literacy-2 (CAPL-2) into Urdu and adapt it for the Pakistani cultural context, to assess PL among children aged 8-12 years in Pakistan. METHOD: The Urdu version of CAPL-2 was administered among 1,360 children aged 8-12 from 87 higher secondary schools across three divisions in South Punjab province, Pakistan. Statistical analysis includes test-retest reliability and construct validity, employing confirmatory factor analysis to evaluate the tool's performance both overall and within specific subdomains. RESULTS: The Urdu version of CAPL-2 demonstrated strong content validity, with a Content Validity Ratio of 0.89. Confirmatory factor analysis supported the four-factor structure proposed by the original developers, evidenced by excellent model fit indices (GFI = 0.984, CFI = 0.979, TLI = 0.969, RMSEA = 0.041). High internal consistency was observed across all domains (alpha = 0.988 to 0.995), with significant correlations among most, excluding the Knowledge and Understanding domains. Notably, gender and age significantly influenced performance, with boys generally scoring higher than girls, with few exceptions. CONCLUSION: This study marks a significant step in the cross-cultural adaptation of PL assessment tools, successfully validating the CAPL-2 Urdu version for the Pakistani context for the first time. The findings affirm the tool's suitability for assessing PL among Pakistani children, evidencing its validity and reliability across the Pakistani population. CI - (c) 2024. The Author(s). FAU - Hadier, Syed Ghufran AU - Hadier SG AUID- ORCID: 0000-0001-5164-5886 AD - School of Physical Education, Shanxi University, Taiyuan, Shanxi, 030006, China. FAU - Liu, Yinghai AU - Liu Y AD - School of Physical Education, Shanxi University, Taiyuan, Shanxi, 030006, China. tyliuyh@sxu.edu.cn. FAU - Long, Liu AU - Long L AD - Department of Physical Education, Suzhou University, Suzhou, Anhui, 234000, China. FAU - Hamdani, Syed Muhammad Zeeshan Haider AU - Hamdani SMZH AUID- ORCID: 0000-0001-7632-0869 AD - Faculty of Social Science, Department of Sports Sciences, Bahauddin Zakariya University, Multan, Punjab, 60800, Pakistan. zeeshanhamdani@bzu.edu.pk. AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. zeeshanhamdani@bzu.edu.pk. FAU - Khurram, Haris AU - Khurram H AUID- ORCID: 0000-0003-1814-4742 AD - Department of Mathematics and Computer Science, Faculty of Science and Technology, Prince of Songkla University, Pattani Campus, Pattani, Thailand. AD - Department of Sciences and Humanities, National University of Computer and Emerging Sciences, Chiniot-Faisalabad Campus, Faisalabad, Pakistan. FAU - Hamdani, Syed Danish AU - Hamdani SD AUID- ORCID: 0009-0002-3320-4678 AD - School Education Department, Multan, South Punjab, 60800, Pakistan. AD - Division of Olympic Sports, China Swimming College, Beijing Sport University, Beijing, China. FAU - Danish, Shaista Shireen AU - Danish SS AD - Department of Sports Sciences, Bahauddin Zakariya University, Multan, Punjab, 60800, Pakistan. AD - Division of Sports and Health, School of Sports Science, Department of Exercise Physiology, Beijing Sport University, Beijing, China. FAU - Fatima, Syeda Urooj AU - Fatima SU AUID- ORCID: 0000-0003-2009-4326 AD - Department of Physical Education, Government College University Faisalabad, Punjab, 38000, Pakistan. LA - eng PT - Journal Article PT - Validation Study DEP - 20240628 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Pakistan MH - Child MH - Male MH - Female MH - Reproducibility of Results MH - *Health Literacy/statistics & numerical data MH - Psychometrics MH - Surveys and Questionnaires/standards MH - Canada MH - Factor Analysis, Statistical MH - Exercise MH - Translations PMC - PMC11212239 OTO - NOTNLM OT - CAPL-2 OT - Confirmatory factor analysis OT - Cross-cultural adaptation OT - Pakistani children OT - Reliability OT - Urdu translation COIS- The authors declare no competing interests. EDAT- 2024/06/29 15:42 MHDA- 2024/06/29 15:43 PMCR- 2024/06/28 CRDT- 2024/06/29 00:06 PHST- 2023/06/22 00:00 [received] PHST- 2024/06/18 00:00 [accepted] PHST- 2024/06/29 15:43 [medline] PHST- 2024/06/29 15:42 [pubmed] PHST- 2024/06/29 00:06 [entrez] PHST- 2024/06/28 00:00 [pmc-release] AID - 10.1186/s12889-024-19185-3 [pii] AID - 19185 [pii] AID - 10.1186/s12889-024-19185-3 [doi] PST - epublish SO - BMC Public Health. 2024 Jun 28;24(1):1726. doi: 10.1186/s12889-024-19185-3. PMID- 38943050 OWN - NLM STAT- MEDLINE DCOM- 20240629 LR - 20240701 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 24 IP - 1 DP - 2024 Jun 28 TI - The potential causal effect of the pre-pregnancy dietary phytochemical index on gestational diabetes mellitus: a prospective cohort study. PG - 447 LID - 10.1186/s12884-024-06643-4 [doi] LID - 447 AB - BACKGROUND: Phytochemicals are non-nutritive bioactive compounds with beneficial effects on the metabolism of glucose. This study aimed to clarify the possible causal effect of the pre-pregnancy dietary phytochemical index (DPI) on gestational diabetes mellitus (GDM). METHODS: In this prospective cohort study 1,856 pregnant women aged 18-45 years who were in their first trimester, were recruited and followed up until delivery. The dietary intakes of participants were examined using an interviewer-administered validated 168-item semi-quantitative food frequency questionnaire (FFQ). Inverse probability weighting (IPW) of propensity scores (PS), estimated from the generalized boosted model (GBM) were used to obtain a adjusted risk ratio (aRR) for potential confounders. RESULTS: During the follow-up period, 369 (19.88%) women were diagnosed with GDM. DPI scores ranged from 6.09 to 89.45. There was no association between DPI scores and GDM (aRR: 1.01, 95% confidence interval [CI]: 0.92, 1.08; p trend = 0.922). When comparing DPI quartile 4 (most pro-phytochemical content) to quartile 1 (few phytochemical contents), there was no significant difference between them (aRR: 0.97; 95% CI: 0.75, 1.25; p = 0.852). Also, there was no significant difference between DPI quartile 3 and quartile 1 (aRR: 1.04; 95% CI: 0.81, 1.34; p = 0.741) as well as DPI quartile 2 and quartile 1 (aRR: 0.92; 95% CI: 0.71, 1.21; p = 0.593). CONCLUSIONS: Although this data did not support the association between pre-pregnancy DPI scores and GDM, further cohort studies to ascertain the causal association between them are warranted. CI - (c) 2024. The Author(s). FAU - Heidarzadeh-Esfahani, Neda AU - Heidarzadeh-Esfahani N AD - Nutritional Sciences Department, School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran. FAU - Heshmati, Javad AU - Heshmati J AD - University of Ottawa Heart Institute, University of Ottawa, Ottawa, Canada. FAU - Pirjani, Reihaneh AU - Pirjani R AD - Department of Obstetrics and Gynecology, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran. FAU - Moini, Ashraf AU - Moini A AD - Department of Obstetrics and Gynecology, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran. AD - Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. FAU - Shafaatdoost, Mehrnoosh AU - Shafaatdoost M AD - Department of Clinical Nutrition, School of Nutritional Sciences and Dietetic, Tehran University of Medical Sciences, Tehran, Iran. FAU - Esmaeili, Mahnaz AU - Esmaeili M AD - Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. FAU - Mardi-Mamaghani, Azar AU - Mardi-Mamaghani A AD - Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. FAU - Nachvak, Seyyed Mostafa AU - Nachvak SM AD - Nutritional Sciences Department, School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran. smnachvak@hotmail.com. FAU - Sepidarkish, Mahdi AU - Sepidarkish M AD - Population, Family and Spiritual Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. mahdi.sepidarkish@gmail.com. LA - eng GR - IR.TUMS.MEDICINE.REC.1398.576/Tehran University of Medical Sciences and Health Services/ GR - IR.TUMS.MEDICINE.REC.1398.576/Tehran University of Medical Sciences and Health Services/ GR - IR.TUMS.MEDICINE.REC.1398.576/Tehran University of Medical Sciences and Health Services/ PT - Journal Article DEP - 20240628 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 RN - 0 (Phytochemicals) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Diabetes, Gestational MH - Adult MH - Prospective Studies MH - Young Adult MH - *Phytochemicals/administration & dosage MH - *Diet MH - Adolescent MH - Middle Aged MH - Risk Factors MH - China/epidemiology MH - Pregnancy Trimester, First MH - Cohort Studies PMC - PMC11212247 OTO - NOTNLM OT - DPI OT - Dietary phytochemical index OT - GDM OT - Gestational diabetes mellitus COIS- The authors declare no competing interests. EDAT- 2024/06/29 15:42 MHDA- 2024/06/29 15:43 PMCR- 2024/06/28 CRDT- 2024/06/29 00:02 PHST- 2023/11/10 00:00 [received] PHST- 2024/06/14 00:00 [accepted] PHST- 2024/06/29 15:43 [medline] PHST- 2024/06/29 15:42 [pubmed] PHST- 2024/06/29 00:02 [entrez] PHST- 2024/06/28 00:00 [pmc-release] AID - 10.1186/s12884-024-06643-4 [pii] AID - 6643 [pii] AID - 10.1186/s12884-024-06643-4 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2024 Jun 28;24(1):447. doi: 10.1186/s12884-024-06643-4. PMID- 38942149 OWN - NLM STAT- MEDLINE DCOM- 20240818 LR - 20260514 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 201 DP - 2024 Oct 1 TI - Investigating motivations to eat: Refining and validating a framework of Eating Behaviour Traits in dieters and the general population. PG - 107543 LID - S0195-6663(24)00346-5 [pii] LID - 10.1016/j.appet.2024.107543 [doi] AB - Due to relationships between diet and health including obesity, there is a need to examine the explanatory power of factors that motivate people to (over or under) eat. In a previous investigation, a four-factor subscale-based model of eating behaviour traits (EBTs) was developed which identified individual differences in psychological factors influencing motivations to eat and some residual uncertainties. The current study used a data-driven and theory-driven approach, including individual items to refine and extend previous EBT models. The aim was to examine and validate the domain structure of a framework for EBTs. The analysis used two samples including a representative sample of the UK population (n = 2010, 51% female, 49% male, 18-88 years), and members of a weight management program (n = 2317, 96.6% female, 2.8% male, 21-84 years), who completed 5 questionnaires including 10 EBTs. The results found some support for a 6-factor model, encompassing reactive eating, negative emotional eating, positive emotional eating, restricted eating, homeostatic eating, and body-food choice congruence (data-driven model) or eating for health (theory-driven model). There were differences between the data-driven model and the theory-driven model regarding the 6th factor. Additionally, the data-driven model did not distinguish between eating for pleasure and reactive eating. The models demonstrated that the eating behaviour factors were significantly associated with BMI category. Overall, this research contributes to a more structured understanding of the dimensions of motivation underlying EBTs, emphasising the utility of this framework for identifying at-risk individuals and tailoring interventions to meet specific individual needs. CI - Copyright (c) 2024. Published by Elsevier Ltd. FAU - Dakin, Clarissa AU - Dakin C AD - University of Leeds, Woodhouse, Leeds, LS2 9JT, UK. Electronic address: clarissa.dakin@gmail.com. FAU - Finlayson, Graham AU - Finlayson G AD - University of Leeds, Woodhouse, Leeds, LS2 9JT, UK. FAU - Stubbs, R James AU - Stubbs RJ AD - University of Leeds, Woodhouse, Leeds, LS2 9JT, UK. LA - eng PT - Journal Article PT - Validation Study DEP - 20240626 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - Male MH - Adult MH - Middle Aged MH - Aged MH - *Feeding Behavior/psychology MH - Adolescent MH - Young Adult MH - *Motivation MH - Aged, 80 and over MH - United Kingdom MH - Surveys and Questionnaires MH - Diet/psychology MH - Eating/psychology MH - Food Preferences/psychology MH - Emotions OTO - NOTNLM OT - Eating behaviour traits OT - Emotional eating OT - Homeostatic eating OT - Pleasure OT - Reactive eating OT - Restricted eating COIS- Declaration of competing interest Pr. James Stubbs declares that he consults for Slimming World UK through the University of Leeds. Slimming World were not involved in the analysis or interpretation of this articles. No other authors declare a conflict of interest. EDAT- 2024/06/29 00:42 MHDA- 2024/08/19 00:42 CRDT- 2024/06/28 19:25 PHST- 2024/03/11 00:00 [received] PHST- 2024/05/28 00:00 [revised] PHST- 2024/06/04 00:00 [accepted] PHST- 2024/08/19 00:42 [medline] PHST- 2024/06/29 00:42 [pubmed] PHST- 2024/06/28 19:25 [entrez] AID - S0195-6663(24)00346-5 [pii] AID - 10.1016/j.appet.2024.107543 [doi] PST - ppublish SO - Appetite. 2024 Oct 1;201:107543. doi: 10.1016/j.appet.2024.107543. Epub 2024 Jun 26. PMID- 38941878 OWN - NLM STAT- MEDLINE DCOM- 20240727 LR - 20250117 IS - 1532-2130 (Electronic) IS - 1090-3798 (Linking) VI - 51 DP - 2024 Jul TI - Validation of the Internet Addiction Test for Adolescents (IAT-A) in the Georgian language. PG - 125-131 LID - S1090-3798(24)00092-8 [pii] LID - 10.1016/j.ejpn.2024.06.006 [doi] AB - BACKGROUND: The internet has become an integral part of daily life, impacting various aspects, especially among children and adolescents. Internet overuse has been associated with numerous physical and mental health issues. Despite its significant implications, there is no universally accepted assessment tool for internet addiction. This study focuses on validating the Georgian version of the Internet Addiction Test (IAT) among pediatric patients aged 9 to 17, specifically the Internet Addiction Test - Adolescence (IAT - A). METHODS: The study, conducted in 2022-2023, involved pediatric patients from Givi Zhvania Pediatric Academic Clinic, generally healthy but with parental concerns about screen time. The IAT-A, a self-administered questionnaire, was adapted for cultural relevance. Translation-back-translation was employed for linguistic validation. Data was collected twice, with a 6-month interval. Statistical analyses included the Kappa coefficient, Kendall's tau test, paired t-test, and Bland-Altman plots. RESULTS: The translation process ensured linguistic accuracy and cultural relevance. The study included 100 participants (59 % boys, 41 % girls) with a mean age of 12 years. The mean IAT - A score remained consistently high over both testing periods. Kendall's tau correlation coefficient indicated a strong correlation (0.97), and Bland-Altman plots confirmed repeatability. The cut-off of 40 points identified 84 % as problematic internet users. Individual question analysis showed strong correlation and agreement. CONCLUSION: The Georgian version of the IAT - A demonstrated reliability and consistency in assessing internet addiction among pediatric patients. The prevalence of problematic internet use among children referred to a university hospital because parents were worried about their internet use was indeed high. The study contributes valuable insights into internet addiction research in Georgia and underscores the importance of a standardized assessment tool. The repeatability of the scores of each question was strong among both groups of problematic internet users and non-problematic internet users, confirming that the Georgian version of IAT - A has high level of accuracy and can be used in internet addiction research. CI - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Nadiradze, T AU - Nadiradze T AD - Department of Pediatric Neurology, Tbilisi State Medical University, Tbilisi, Georgia. Electronic address: T.nadiradze@tsmu.edu. FAU - Bakhtadze, S AU - Bakhtadze S AD - Department of Pediatric Neurology, Tbilisi State Medical University, Tbilisi, Georgia. FAU - Kvachadze, I AU - Kvachadze I AD - Department of Physiology, Tbilisi State Medical University, Tbilisi, Georgia. FAU - Khachapuridze, N AU - Khachapuridze N AD - Department of Pediatric Neurology, Tbilisi State Medical University, Tbilisi, Georgia. LA - eng PT - Journal Article PT - Review DEP - 20240619 PL - England TA - Eur J Paediatr Neurol JT - European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society JID - 9715169 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Behavior, Addictive/diagnosis MH - Georgia (Republic) MH - Internet MH - *Internet Addiction Disorder/diagnosis MH - Language MH - Psychometrics/standards/methods/instrumentation MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - Translations OTO - NOTNLM OT - Cross-cultural validation OT - Cultural adaptation of IAT questionnaire OT - Georgia OT - Internet addiction assessment OT - Internet addiction test reliability OT - Pediatric population study OT - Prevalence of internet addiction OT - Screen time impact COIS- Declaration of competing interest The authors declare that they have no conflicts of interest, whether financial or non-financial, that could potentially influence or bias the content of this article. All authors affirm that they have no affiliations with, or involvement in, any organization or entity with either a financial or non-financial interest in the subject matter or materials discussed in this manuscript. Furthermore, the authors assert that they hold no financial or proprietary interests in any material presented or discussed within the confines of this article. This study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of Tbilisi State Medical University Zhvania Academic Clinics of Pediatrics (protocol code N03). The authors adhere to the principles outlined in the Declaration of Helsinki to ensure the ethical conduct of research involving human subjects. EDAT- 2024/06/29 00:42 MHDA- 2024/07/28 14:46 CRDT- 2024/06/28 18:07 PHST- 2024/02/06 00:00 [received] PHST- 2024/06/17 00:00 [revised] PHST- 2024/06/18 00:00 [accepted] PHST- 2024/07/28 14:46 [medline] PHST- 2024/06/29 00:42 [pubmed] PHST- 2024/06/28 18:07 [entrez] AID - S1090-3798(24)00092-8 [pii] AID - 10.1016/j.ejpn.2024.06.006 [doi] PST - ppublish SO - Eur J Paediatr Neurol. 2024 Jul;51:125-131. doi: 10.1016/j.ejpn.2024.06.006. Epub 2024 Jun 19. PMID- 41878660 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260325 LR - 20260813 IS - 2772-6967 (Electronic) IS - 2772-6967 (Linking) VI - 4 DP - 2024 Dec TI - Evaluating the measurement properties and feasibility of physical activity and physical function assessments for children undergoing acute cancer treatment. PG - 100065 LID - 10.1016/j.jsampl.2024.100065 [doi] LID - 100065 AB - BACKGROUND: As physical function and physical activity are often compromised among children and adolescents undergoing acute cancer treatment, psychometrically robust and feasible assessment tools are needed. The aim of this study is to evaluate the construct validity, responsiveness and feasibility of one physical activity assessment tool (Fitbit Inspire); and six physical function assessment tools (Movement ABC-2, Timed Up and Go, 30-s Chair Stand, Timed Rise from the Floor, Timed Up and Down Stairs, 6-min Walk Test) for children undergoing acute cancer treatment. METHODS: A prospectively-registered, mixed methods, single-group study evaluated measurement properties against a priori hypothesis using Consensus-based Standards for the selection of health status Measurement Instruments (COSMIN) framework. Feasibility was assessed quantitively (a priori thresholds), and qualitatively (semi-structured interviews, focus-groups). RESULTS: Twenty children/adolescents (median age 13 ​+/- ​5 years, various cancer diagnoses), 20 parents and 16 clinicians participated. Fitbit was feasible to assess daily steps only, had evidence of construct validity, tendency to overestimate step count and adequate evidence of responsiveness (compared to Actigraph). The 30-s Chair stand, 6-min Walk Test and Timed Up and Go were feasible and showed evidence of construct validity and responsiveness. To maximise feasibility, consideration of timing and intent of assessment are crucial. CONCLUSION: Fitbit has limitations as a physical activity assessment tool. The 30-s Chair Stand, 6-min Walk Test and Timed Up and Go were feasible to use and showed favourable measurement properties to assess physical function. CI - (c) 2024 The Authors. FAU - Grimshaw, Sarah L AU - Grimshaw SL AD - La Trobe University, School of Allied Health, Human Services and Sport, Bundoora, Melbourne, VIC, 3086, Australia. AD - Murdoch Children's Research Institute, Parkville, Melbourne, VIC, 3052, Australia. AD - Children's Cancer Centre, The Royal Children's Hospital, Parkville, Melbourne, VIC, 3052, Australia. FAU - Taylor, Nicholas F AU - Taylor NF AD - La Trobe University, School of Allied Health, Human Services and Sport, Bundoora, Melbourne, VIC, 3086, Australia. FAU - Conyers, Rachel AU - Conyers R AD - Murdoch Children's Research Institute, Parkville, Melbourne, VIC, 3052, Australia. AD - Department of Paediatrics, University of Melbourne, Carlton, Melbourne, VIC, 3052, Australia. AD - Children's Cancer Centre, The Royal Children's Hospital, Parkville, Melbourne, VIC, 3052, Australia. FAU - Shields, Nora AU - Shields N AD - Murdoch Children's Research Institute, Parkville, Melbourne, VIC, 3052, Australia. AD - La Trobe University, Olga Tennison Autism Research Centre, School of Psychology and Public Health, Bundoora, VIC, 3086, Australia. LA - eng PT - Journal Article DEP - 20240628 PL - England TA - JSAMS Plus JT - JSAMS plus JID - 9918505286106676 PMC - PMC13008446 OTO - NOTNLM OT - COSMIN OT - Cancer OT - Child OT - Measurement properties OT - Physical activity OT - Physical function COIS- The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Sarah L Grimshaw reports financial support was provided by Little Big Steps. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/06/28 00:00 MHDA- 2024/06/28 00:01 PMCR- 2024/06/28 CRDT- 2026/03/25 04:33 PHST- 2023/12/20 00:00 [received] PHST- 2024/04/14 00:00 [revised] PHST- 2024/06/09 00:00 [accepted] PHST- 2024/06/28 00:01 [medline] PHST- 2024/06/28 00:00 [pubmed] PHST- 2026/03/25 04:33 [entrez] PHST- 2024/06/28 00:00 [pmc-release] AID - S2772-6967(24)00013-9 [pii] AID - 100065 [pii] AID - 10.1016/j.jsampl.2024.100065 [doi] PST - epublish SO - JSAMS Plus. 2024 Jun 28;4:100065. doi: 10.1016/j.jsampl.2024.100065. eCollection 2024 Dec. PMID- 38941548 OWN - NLM STAT- MEDLINE DCOM- 20240628 LR - 20250731 IS - 1537-8918 (Electronic) IS - 1537-890X (Linking) VI - 23 IP - 7 DP - 2024 Jul 1 TI - Contemporary Issue: Health and Safety of Female Wrestlers. PG - 262-269 LID - 10.1249/JSR.0000000000001183 [doi] AB - Female wrestling has grown exponentially over the past decade. Within the United States, 46 states now recognize female high school wrestling, and 153 colleges have programs. It is on track to become an NCAA championship-level sport in 2026. A primary health and safety risk among this cohort pertains to rapid weight loss strategies. These can lead to intentional caloric restriction and decreased body fatness, with the perceived goal of attaining a competitive advantage. Low energy availability and low body fatness are associated with a number of health concerns including menstrual dysfunction and loss of bone mineral density in girls and women. The current recommendation of 12% as a minimum for percentage body fat is very likely too low, opening the door for health perturbations among this population. The minimum threshold might more appropriately fall within the range of 18% to 20%. Body fat assessment methods, primarily skinfold measures that are used to guide weight class selection, have not been adequately validated among this population and therefore should be an area of research focus, while also exploring alternative assessment techniques. Further, we recommend that weight cycling, restrictive energy intake, and intentional dehydration be avoided. Research should assess the effects of frequent weight cycling (to "make weight") and prolonged periods of low body fat on the reproductive and bone health of these athletes. Finally, research and clinical evaluations on female wrestlers are limited, and we offer a list of research priorities for future investigation into this contemporary issue. CI - Copyright (c) 2024 by the American College of Sports Medicine. FAU - Jagim, Andrew R AU - Jagim AR AD - Sports Medicine, Mayo Clinic Health System, La Crosse, WI. FAU - Moschelli, Jill S AU - Moschelli JS AD - Sports Medicine and Orthopedics, Michigan State University, East Lansing, MI. FAU - Woodroffe, Lisa M AU - Woodroffe LM AD - Sports Medicine, University of Iowa, Iowa City, IA. FAU - Horswill, Craig A AU - Horswill CA AD - Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL. FAU - Bloomfield, Susan A AU - Bloomfield SA AD - Kinesiology and Sport Management, Texas A&M University - College Station, TX. FAU - Oppliger, Robert A AU - Oppliger RA AD - FACSM Emeritus, Iowa City, IA. LA - eng PT - Journal Article PT - Review DEP - 20240701 PL - United States TA - Curr Sports Med Rep JT - Current sports medicine reports JID - 101134380 SB - IM MH - Female MH - Humans MH - Bone Density MH - Menstruation Disturbances/etiology MH - Weight Loss MH - *Wrestling EDAT- 2024/06/28 18:42 MHDA- 2024/06/28 18:43 CRDT- 2024/06/28 15:13 PHST- 2024/06/28 18:43 [medline] PHST- 2024/06/28 18:42 [pubmed] PHST- 2024/06/28 15:13 [entrez] AID - 00149619-202407000-00005 [pii] AID - 10.1249/JSR.0000000000001183 [doi] PST - epublish SO - Curr Sports Med Rep. 2024 Jul 1;23(7):262-269. doi: 10.1249/JSR.0000000000001183. PMID- 38940391 OWN - NLM STAT- MEDLINE DCOM- 20240813 LR - 20260609 IS - 1467-3010 (Electronic) IS - 1467-3010 (Linking) VI - 49 IP - 3 DP - 2024 Sep TI - Cross-sectional study examining the association between diet quality and the prevalence of anxiety and depression in UK undergraduate students. PG - 383-395 LID - 10.1111/nbu.12694 [doi] AB - The prevalence of mental health issues among UK undergraduate students is growing, and poor diet quality appears to be a risk factor for poor mental health although with limited research in this area. Therefore, the objective of this study was to examine the cross-sectional associations between diet quality and common mental disorders (CMD) such as depression and anxiety in UK undergraduate students. A cross-sectional survey consisting of demographic information and validated questionnaires (the Short-Form Food Frequency Questionnaire [SFFFQ] and the Hospital Anxiety and Depression Scale [HADS]) was conducted to measure diet quality and anxiety and depression in young adults in 44 UK-based universities. Multiple regression analysis adjusting for confounding factors was used to assess the associations between them. Undergraduate university students (n = 202, 67% female) with a mean age of 20.9 +/- 3.6 years and a mean body mass index (n = 170) of 22.6 +/- 3.2 kg/m(2) took part in the study. Prevalence of anxiety was high, with 40% of the sample having an anxiety score in the severe range (>/=12 points) while the prevalence of depression was lower, with 6% of the population having a depression score in the severe range (>/=12 points). Diet quality was significantly higher for females than males (p = 0.034) and was poor for 38% of the sample, being more common in males compared to females, although not significantly so (43% and 36%, respectively). Diet quality was inversely associated with anxiety (beta = -0.427; p = 0.029) and was more likely to be associated with anxiety in females than males (beta = 0.743; p = 0.043). No significant relationship between diet quality and depression was found. Better self-reported health, father's qualification and smoking status were also associated with less anxiety and depression. This research supports other research suggesting that UK universities should explore whether the implementation of dietary interventions and improving the food environment would be a cost-effective option to reduce the high prevalence of anxiety among students. CI - (c) 2024 The Author(s). Nutrition Bulletin published by John Wiley & Sons Ltd on behalf of British Nutrition Foundation. FAU - Myrissa, Kyriaki AU - Myrissa K AUID- ORCID: 0000-0003-1878-1645 AD - Faculty of Sport, Allied Health and Performance Science, St Mary's University, Twickenham, UK. FAU - Court, Catherine AU - Court C AD - Faculty of Sport, Allied Health and Performance Science, St Mary's University, Twickenham, UK. FAU - Kelaiditi, Eirini AU - Kelaiditi E AD - Faculty of Sport, Allied Health and Performance Science, St Mary's University, Twickenham, UK. LA - eng PT - Journal Article DEP - 20240628 PL - England TA - Nutr Bull JT - Nutrition bulletin JID - 9315625 SB - IM MH - Humans MH - Female MH - Male MH - Cross-Sectional Studies MH - Young Adult MH - *Depression/epidemiology MH - *Anxiety/epidemiology MH - United Kingdom/epidemiology MH - Prevalence MH - *Students/psychology/statistics & numerical data MH - *Diet MH - Universities MH - Adult MH - Adolescent MH - Surveys and Questionnaires OTO - NOTNLM OT - anxiety OT - depression OT - diet quality OT - students OT - undergraduate EDAT- 2024/06/28 12:42 MHDA- 2024/08/13 12:41 CRDT- 2024/06/28 07:43 PHST- 2024/06/11 00:00 [revised] PHST- 2023/04/19 00:00 [received] PHST- 2024/06/12 00:00 [accepted] PHST- 2024/08/13 12:41 [medline] PHST- 2024/06/28 12:42 [pubmed] PHST- 2024/06/28 07:43 [entrez] AID - 10.1111/nbu.12694 [doi] PST - ppublish SO - Nutr Bull. 2024 Sep;49(3):383-395. doi: 10.1111/nbu.12694. Epub 2024 Jun 28. PMID- 38938517 OWN - NLM STAT- MEDLINE DCOM- 20240628 LR - 20260611 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 15 DP - 2024 TI - Association between systemic immunity-inflammation index and sex hormones in children and adolescents aged 6-19. PG - 1355738 LID - 10.3389/fendo.2024.1355738 [doi] LID - 1355738 AB - OBJECTIVES: This study aimed to evaluate the relationship between systemic immune-inflammation index (SII) and sex hormones in children and adolescents aged 6-19 years. METHODS: Data were obtained from the National Health and Nutrition Examination Survey (NHANES) conducted between 2013 and 2016. Inclusion criteria comprised subjects aged 6-19 years with complete data on both SII and sex hormones. We employed weighted multiple regression analysis and subgroup analytical methods to independently estimate the relationship between SII and sex hormones. RESULTS: In this study, a total of 3767 participants were included, with an average age of 12.32 +/- 3.95 years. Males constituted 50.54%, and females 49.46%. Among males, a statistically significant negative correlation emerged between SII and sex hormone-binding globulin (SHBG). Similarly, in the female population, SII exhibited a statistically significant negative correlation with total testosterone (TT), SHBG, and the Ratio of TT to estradiol, while maintaining a positive correlation with free androgen index (FAI). Subgroup analysis underscored variances in the association between sex hormones and SII within cohorts distinguished by pubertal status or different body mass index (BMI). In addition, the relationship between SII and estradiol exhibited nonlinearity. Employing a two-segment linear regression model, we identified an inverted U-shaped association between SII and estradiol, with an inflection point of 748.09 (1000cell/ml). CONCLUSION: Our findings suggest that SII may be an independent risk factor for changes in sex hormones in both male and female children and adolescents. More prospective and experimental studies should be conducted to validate our results and elucidate the underlying molecular pathways. CI - Copyright (c) 2024 Gao and Liu. FAU - Gao, Zijun AU - Gao Z AD - Department of Laboratory Medicine, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Liu, Ke AU - Liu K AD - Department of Laboratory Medicine, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. LA - eng PT - Journal Article DEP - 20240613 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Gonadal Steroid Hormones) RN - 0 (Sex Hormone-Binding Globulin) RN - 3XMK78S47O (Testosterone) RN - 4TI98Z838E (Estradiol) SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - Child MH - *Gonadal Steroid Hormones/blood MH - *Inflammation/blood/immunology MH - Young Adult MH - *Sex Hormone-Binding Globulin/metabolism/analysis MH - Nutrition Surveys MH - Cross-Sectional Studies MH - Body Mass Index MH - Testosterone/blood MH - Estradiol/blood MH - Immunity PMC - PMC11208618 OTO - NOTNLM OT - NHANES OT - adolescents OT - children OT - sex hormones OT - systemic immune-inflammation index COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/06/28 06:42 MHDA- 2024/06/28 06:43 PMCR- 2024/01/01 CRDT- 2024/06/28 04:47 PHST- 2023/12/14 00:00 [received] PHST- 2024/06/03 00:00 [accepted] PHST- 2024/06/28 06:43 [medline] PHST- 2024/06/28 06:42 [pubmed] PHST- 2024/06/28 04:47 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2024.1355738 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2024 Jun 13;15:1355738. doi: 10.3389/fendo.2024.1355738. eCollection 2024. PMID- 38933793 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240628 IS - 0970-0218 (Print) IS - 1998-3581 (Electronic) IS - 0970-0218 (Linking) VI - 49 IP - 3 DP - 2024 May-Jun TI - Validity of "Mid-Upper Arm Circumference" as a Parameter to Identify Undernourished Children in Rural Gujarat. PG - 475-479 LID - 10.4103/ijcm.ijcm_789_22 [doi] AB - INTRODUCTION: Mid-upper arm circumference (MUAC) measures the arm muscle and fat area. The use of MUAC as a screening measure for assessing undernutrition has the following advantages; it makes use of a simple equipment, is easy to carry at the field sites, and requires minimal training. In India, "mid-upper arm circumference" is widely used and accepted in many nutritional programs. OBJECTIVES: This study was conducted with the primary objective to compare different anthropometric parameters of children and to validate the usefulness and limitations of MUAC to screen out undernourished children. SUBJECT AND METHODS: Anthropometric measurements were recorded for all the anganwadi centers of the selected sub-center that comes under the field practice area of our department. The measurements like weight, height, MUAC were done according to the standard guidelines as per WHO, and further, calculations were done with the help of "Anthro software 3.2.2." Comparisons were done between categorization of MUAC tape and Weight-for-Height Z-scores (WHZ), and hence, the sensitivity and specificity of the MUAC tape to screen the malnourished child were found out. RESULTS: Sensitivity of MUAC to categorize a child in red/yellow was only 9.03%, negative predictive value (NPV) was 40.75%, specificity came 95.10%, and positive predictive value was 73.68% on taking WHZ as the gold standard. CONCLUSION: MUAC has a limited role in screening out an undernourished child (red/yellow category), whereas it has a good role in screening healthy children (green category). CI - Copyright: (c) 2024 Indian Journal of Community Medicine. FAU - Chawada, Bansari L AU - Chawada BL AD - Department of Community Medicine, Medical College Baroda, Gujarat, India. FAU - Devaliya, Jaydeep J AU - Devaliya JJ AD - Community Medicine, GMERS Medical College, Vadnagar, Gujarat, India. FAU - Kurian, Sneha AU - Kurian S AD - Department of Community Medicine, Medical College Baroda, Gujarat, India. LA - eng PT - Journal Article DEP - 20240524 PL - India TA - Indian J Community Med JT - Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine JID - 9315574 PMC - PMC11198527 OTO - NOTNLM OT - MUAC OT - WHZ OT - undernutrition COIS- There are no conflicts of interest. EDAT- 2024/06/27 06:42 MHDA- 2024/06/27 06:43 PMCR- 2024/05/01 CRDT- 2024/06/27 04:36 PHST- 2022/09/20 00:00 [received] PHST- 2024/02/13 00:00 [accepted] PHST- 2024/06/27 06:43 [medline] PHST- 2024/06/27 06:42 [pubmed] PHST- 2024/06/27 04:36 [entrez] PHST- 2024/05/01 00:00 [pmc-release] AID - IJCM-49-475 [pii] AID - 10.4103/ijcm.ijcm_789_22 [doi] PST - ppublish SO - Indian J Community Med. 2024 May-Jun;49(3):475-479. doi: 10.4103/ijcm.ijcm_789_22. Epub 2024 May 24. PMID- 38931285 OWN - NLM STAT- MEDLINE DCOM- 20240627 LR - 20240629 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 12 DP - 2024 Jun 18 TI - Is Adherence to the Saudi Healthy Plate Dietary Guidelines Associated with Eating Concerns Symptoms among Saudi Young Females? LID - 10.3390/nu16121931 [doi] LID - 1931 AB - BACKGROUND: Food-based dietary guidelines (FBDGs) offer broad recommendations based on scientific evidence, focusing on food groups rather than nutrients that should be included in the diet. Emerging adulthood (18-30 years) is a critical period for poor dietary quality and mental health. Eating habits (EHs) are formed early in life and are influenced by various factors, such as emotional state, which can lead to either binge or restricted eating, ultimately increasing the risk of eating disorders (EDs). This cross-sectional study aimed to investigate the extent of adherence to the Saudi Healthy Plate Dietary Guidelines (SHPDGs) and its potential association with Eating Concerns (ECs) among Saudi females (aged 18-30 years) from all provinces in the Kingdom of Saudi Arabia. METHODS: A validated online questionnaire was used to assess eating behaviors (EBs) using the Starting The Conversation (STC) instrument and EC symptoms using the Eating Disorders Screen for Primary Care (ESP) screening tool. RESULTS: The total sample size was 1092 participants with a mean age of 23.02 +/- 3.47. Only 0.7% of the participants adhered to the SHPDGs and were free of EC symptoms. Conversely, 50.4% of participants who exhibited EC symptoms had poor adherence to the SHPDGs. Across Saudi Arabian provinces, high adherence to the SHPDGs was more prominent in both the Eastern and Western provinces (37.5%) than in the Central and Southern provinces (0%). The most striking result was that the Central province exhibited a high percentage of poor adherence to the SHPDGs (25.6%). Moreover, high adherence to SHPDGs was not associated with the probability of ECs. CONCLUSIONS: The present study revealed a trend of poor adherence to SHPDGs among Saudi females, with a large proportion also experiencing EC symptoms. Accordingly, the authors recommend increasing awareness within the Saudi community about SHPDGs using educational campaigns on social media platforms to enhance the importance of adopting a healthy diet, especially among females, and demonstrate that the impact on their health and well-being is that they are experiencing multiple phases that involve pregnancy and giving birth involves specific nutritional requirements. FAU - Al-Bisher, Mona Mohammed AU - Al-Bisher MM AUID- ORCID: 0000-0003-4708-5593 AD - Department of Food and Nutrition Science, College of Agricultural and Food Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia. FAU - Al-Otaibi, Hala Hazam AU - Al-Otaibi HH AUID- ORCID: 0000-0002-4585-5120 AD - Department of Food and Nutrition Science, College of Agricultural and Food Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia. LA - eng PT - Journal Article DEP - 20240618 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Saudi Arabia MH - Young Adult MH - Adult MH - Adolescent MH - Cross-Sectional Studies MH - *Feeding Behavior/psychology MH - *Feeding and Eating Disorders/epidemiology/psychology MH - *Nutrition Policy MH - Surveys and Questionnaires MH - Diet, Healthy/statistics & numerical data/psychology MH - Guideline Adherence/statistics & numerical data PMC - PMC11206548 OTO - NOTNLM OT - Saudi Healthy Plate Dietary Guidelines OT - Saudi young females OT - eating behaviors OT - eating concerns OT - food-based dietary guidelines COIS- The authors declare no conflicts of interest. EDAT- 2024/06/27 06:42 MHDA- 2024/06/27 06:43 PMCR- 2024/06/18 CRDT- 2024/06/27 01:22 PHST- 2024/05/22 00:00 [received] PHST- 2024/06/11 00:00 [revised] PHST- 2024/06/17 00:00 [accepted] PHST- 2024/06/27 06:43 [medline] PHST- 2024/06/27 06:42 [pubmed] PHST- 2024/06/27 01:22 [entrez] PHST- 2024/06/18 00:00 [pmc-release] AID - nu16121931 [pii] AID - nutrients-16-01931 [pii] AID - 10.3390/nu16121931 [doi] PST - epublish SO - Nutrients. 2024 Jun 18;16(12):1931. doi: 10.3390/nu16121931. PMID- 38931251 OWN - NLM STAT- MEDLINE DCOM- 20240627 LR - 20240629 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 12 DP - 2024 Jun 16 TI - Evaluation of Nutrition and Performance Parameters in Division 1 Collegiate Athletes. LID - 10.3390/nu16121896 [doi] LID - 1896 AB - BACKGROUND: Testing and evaluating athletes is necessary and should include performance, body composition, and nutrition. The purpose of this study was to report assessments of dietary intake, V O(2max), and body composition in D1 collegiate athletes and examine relationships between these assessments. METHODS: Dietary intake was assessed with 3-day recalls and compared to recommendations, and body composition was assessed via bioelectrical impedance analysis (BIA) (n = 48). V O(2max) was evaluated using a graded exercise test (GXT) with a verification bout (n = 35). Reliability between "true" V O(2max) and verification was determined. Correlations and regressions were performed. RESULTS: Energy, carbohydrate, and micronutrient intake was lower than recommendations. Mean V O(2max) was 47.3 and 47.4 mL.kg(-1).min(-1) for GXT and verification, respectively. While correlations were apparent among dietary intake, V O(2max), and body composition, percent fat-free mass (%FFM) predicted 36% of V O(2max). CONCLUSIONS: Collegiate athletes are not meeting energy and carbohydrate recommendations and exceed fat recommendations. Vitamin D and magnesium were low in all sports, and iron and calcium were low in females. V O(2max) ranged from 35.6 to 63.0 mL.kg(-1).min(-1), with females below average and males meeting typical values for their designated sport. Assessing D1 athletes can provide guidance for sports dietitians, coaches, and strength and conditioning specialists to track and monitor nutrition in athletes. FAU - Shoemaker, Marni E AU - Shoemaker ME AUID- ORCID: 0000-0002-1606-4514 AD - School of Health and Consumer Sciences, South Dakota State University, Brookings, SD 57007, USA. FAU - Dicks, Nathan D AU - Dicks ND AUID- ORCID: 0000-0002-6562-1348 AD - Department of Health, Nutrition, and Exercise Sciences, North Dakota State University, Fargo, ND 58102, USA. FAU - Northrup, Megan J AU - Northrup MJ AD - School of Health and Consumer Sciences, South Dakota State University, Brookings, SD 57007, USA. FAU - Daughters, Seth W AU - Daughters SW AD - School of Health and Consumer Sciences, South Dakota State University, Brookings, SD 57007, USA. FAU - Krings, Taylor N AU - Krings TN AD - School of Health and Consumer Sciences, South Dakota State University, Brookings, SD 57007, USA. FAU - Barry, Allison M AU - Barry AM AUID- ORCID: 0000-0001-7791-6680 AD - School of Health and Consumer Sciences, South Dakota State University, Brookings, SD 57007, USA. LA - eng GR - Hatch Act, Accession No: 7004075/United States Department of Agriculture/ GR - 334714/RSCA Challenge Grant, South Dakota State University/ PT - Journal Article DEP - 20240616 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Dietary Carbohydrates) SB - IM MH - Humans MH - Female MH - Male MH - *Body Composition MH - *Athletes MH - Young Adult MH - *Nutritional Status MH - Athletic Performance/physiology MH - Energy Intake MH - Oxygen Consumption/physiology MH - Universities MH - Adolescent MH - Electric Impedance MH - Dietary Carbohydrates/administration & dosage MH - Nutrition Assessment MH - Exercise Test/methods MH - Diet MH - Sports Nutritional Physiological Phenomena PMC - PMC11206669 OTO - NOTNLM OT - aerobic capacity OT - fat-free mass OT - maximal oxygen uptake OT - sports nutrition COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2024/06/27 06:43 MHDA- 2024/06/27 06:44 PMCR- 2024/06/16 CRDT- 2024/06/27 01:22 PHST- 2024/05/21 00:00 [received] PHST- 2024/06/10 00:00 [revised] PHST- 2024/06/14 00:00 [accepted] PHST- 2024/06/27 06:44 [medline] PHST- 2024/06/27 06:43 [pubmed] PHST- 2024/06/27 01:22 [entrez] PHST- 2024/06/16 00:00 [pmc-release] AID - nu16121896 [pii] AID - nutrients-16-01896 [pii] AID - 10.3390/nu16121896 [doi] PST - epublish SO - Nutrients. 2024 Jun 16;16(12):1896. doi: 10.3390/nu16121896. PMID- 38931220 OWN - NLM STAT- MEDLINE DCOM- 20240627 LR - 20240629 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 12 DP - 2024 Jun 14 TI - Culinary Comfort: Understanding the Connection between Food and Well-Being. LID - 10.3390/nu16121865 [doi] LID - 1865 AB - This study investigated the complex interaction between individuals' culinary tastes, at-home dining habits, and their broader impact on general well-being and relationships dynamics. An all-encompassing tool for assessing the impact of dietary choices on emotions related to coziness, social interaction, and general wellness, the multidimensional Culinary Comfort and Connection Index (CCCI) focuses on traditional home-cooked meals, in particular. We used an online-based survey to validate the CCCI. With a Cronbach alpha of 0.844, this scale is reliable and valid. It covers a wide range of aspects including self-care advocacy, traditional values, and a preference for handmade food. We performed descriptive and stratified analyses and tested correlations. The CCCI shows complicated patterns when analyzed with respect to gender, education level, and family income that demonstrate a myriad of factors impacting people's views on food and its relationship to health. While some patterns emerged, the results imply that dietary choices do not necessarily correlate with overall health. The research highlights the complex interaction between cultural, societal, and personal elements in determining perspectives on nutrition and health by drawing on theoretical models like Bronfenbrenner's ecological systems theory and the Theory of Planned Behavior. Future research should incorporate broader age ranges, longitudinal designs, different populations, objective measurements, and intervention trials to better understand the dynamic link between dietary preferences and health outcomes. FAU - Yasmeen, Bushra AU - Yasmeen B AD - School of Sociology, Minhaj University, Lahore 54770, Pakistan. FAU - Iftikhar, Ifra AU - Iftikhar I AD - Department of Mass Communication, Lahore Garrison University, Lahore 54000, Pakistan. FAU - Fischer, Florian AU - Fischer F AUID- ORCID: 0000-0002-4388-1245 AD - Institute of Public Health, Charite-Universitatsmedizin Berlin, 10117 Berlin, Germany. LA - eng PT - Journal Article DEP - 20240614 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Male MH - Adult MH - *Food Preferences/psychology MH - Middle Aged MH - *Cooking MH - Feeding Behavior/psychology MH - Young Adult MH - Aged MH - Surveys and Questionnaires MH - Adolescent MH - Diet/psychology MH - Choice Behavior MH - Meals/psychology MH - Taste MH - Diet, Healthy/psychology PMC - PMC11206277 OTO - NOTNLM OT - Culinary Comfort and Connection Index (CCCI) OT - relationships dynamics OT - social-ecological model OT - well-being COIS- The authors declare no conflicts of interest. EDAT- 2024/06/27 06:42 MHDA- 2024/06/27 06:43 PMCR- 2024/06/14 CRDT- 2024/06/27 01:22 PHST- 2024/05/24 00:00 [received] PHST- 2024/06/08 00:00 [revised] PHST- 2024/06/11 00:00 [accepted] PHST- 2024/06/27 06:43 [medline] PHST- 2024/06/27 06:42 [pubmed] PHST- 2024/06/27 01:22 [entrez] PHST- 2024/06/14 00:00 [pmc-release] AID - nu16121865 [pii] AID - nutrients-16-01865 [pii] AID - 10.3390/nu16121865 [doi] PST - epublish SO - Nutrients. 2024 Jun 14;16(12):1865. doi: 10.3390/nu16121865. PMID- 38931161 OWN - NLM STAT- MEDLINE DCOM- 20240627 LR - 20240629 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 12 DP - 2024 Jun 8 TI - Validation of an Artificial Intelligence-Based Ultrasound Imaging System for Quantifying Muscle Architecture Parameters of the Rectus Femoris in Disease-Related Malnutrition (DRM). LID - 10.3390/nu16121806 [doi] LID - 1806 AB - (1) Background: The aim was to validate an AI-based system compared to the classic method of reading ultrasound images of the rectus femur (RF) muscle in a real cohort of patients with disease-related malnutrition. (2) Methods: One hundred adult patients with DRM aged 18 to 85 years were enrolled. The risk of DRM was assessed by the Global Leadership Initiative on Malnutrition (GLIM). The variation, reproducibility, and reliability of measurements for the RF subcutaneous fat thickness (SFT), muscle thickness (MT), and cross-sectional area (CSA), were measured conventionally with the incorporated tools of a portable ultrasound imaging device (method A) and compared with the automated quantification of the ultrasound imaging system (method B). (3) Results: Measurements obtained using method A (i.e., conventionally) and method B (i.e., raw images analyzed by AI), showed similar values with no significant differences in absolute values and coefficients of variation, 58.39-57.68% for SFT, 30.50-28.36% for MT, and 36.50-36.91% for CSA, respectively. The Intraclass Correlation Coefficient (ICC) for reliability and consistency analysis between methods A and B showed correlations of 0.912 and 95% CI [0.872-0.940] for SFT, 0.960 and 95% CI [0.941-0.973] for MT, and 0.995 and 95% CI [0.993-0.997] for CSA; the Bland-Altman Analysis shows that the spread of points is quite uniform around the bias lines with no evidence of strong bias for any variable. (4) Conclusions: The study demonstrated the consistency and reliability of this new automatic system based on machine learning and AI for the quantification of ultrasound imaging of the muscle architecture parameters of the rectus femoris muscle compared with the conventional method of measurement. FAU - Garcia-Herreros, Sergio AU - Garcia-Herreros S AD - DAWAKO Medtech S.L., Parc Cientific de la Universitat de Valencia, Calle del Catedratic Agustin Escardino Benlloch, 9, 46980 Paterna, Spain. FAU - Lopez Gomez, Juan Jose AU - Lopez Gomez JJ AUID- ORCID: 0000-0003-3144-343X AD - Investigation Centre Endocrinology and Nutrition, Faculty of Medicine, University of Valladolid, 47003 Valladolid, Spain. AD - Endocrinology and Nutrition Department, Clinical Universitary Hospital of Valladolid, 47003 Valladolid, Spain. FAU - Cebria, Angela AU - Cebria A AD - DAWAKO Medtech S.L., Parc Cientific de la Universitat de Valencia, Calle del Catedratic Agustin Escardino Benlloch, 9, 46980 Paterna, Spain. FAU - Izaola, Olatz AU - Izaola O AD - Investigation Centre Endocrinology and Nutrition, Faculty of Medicine, University of Valladolid, 47003 Valladolid, Spain. AD - Endocrinology and Nutrition Department, Clinical Universitary Hospital of Valladolid, 47003 Valladolid, Spain. FAU - Salvador Coloma, Pablo AU - Salvador Coloma P AUID- ORCID: 0000-0003-3370-0196 AD - DAWAKO Medtech S.L., Parc Cientific de la Universitat de Valencia, Calle del Catedratic Agustin Escardino Benlloch, 9, 46980 Paterna, Spain. FAU - Nozal, Sara AU - Nozal S AD - DAWAKO Medtech S.L., Parc Cientific de la Universitat de Valencia, Calle del Catedratic Agustin Escardino Benlloch, 9, 46980 Paterna, Spain. FAU - Cano, Jesus AU - Cano J AD - DAWAKO Medtech S.L., Parc Cientific de la Universitat de Valencia, Calle del Catedratic Agustin Escardino Benlloch, 9, 46980 Paterna, Spain. FAU - Primo, David AU - Primo D AUID- ORCID: 0000-0002-3474-0766 AD - Investigation Centre Endocrinology and Nutrition, Faculty of Medicine, University of Valladolid, 47003 Valladolid, Spain. FAU - Godoy, Eduardo Jorge AU - Godoy EJ AUID- ORCID: 0000-0001-5625-2846 AD - DAWAKO Medtech S.L., Parc Cientific de la Universitat de Valencia, Calle del Catedratic Agustin Escardino Benlloch, 9, 46980 Paterna, Spain. FAU - de Luis, Daniel AU - de Luis D AUID- ORCID: 0000-0002-1745-9315 AD - Investigation Centre Endocrinology and Nutrition, Faculty of Medicine, University of Valladolid, 47003 Valladolid, Spain. AD - Endocrinology and Nutrition Department, Clinical Universitary Hospital of Valladolid, 47003 Valladolid, Spain. LA - eng PT - Journal Article PT - Validation Study DEP - 20240608 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Ultrasonography/methods MH - Middle Aged MH - Aged MH - Male MH - Female MH - Adult MH - Reproducibility of Results MH - *Malnutrition/diagnostic imaging/diagnosis MH - Aged, 80 and over MH - *Artificial Intelligence MH - Young Adult MH - *Quadriceps Muscle/diagnostic imaging MH - Adolescent PMC - PMC11206908 OTO - NOTNLM OT - artificial intelligence OT - disease-related malnutrition OT - muscle architecture parameters OT - reliability OT - reproducibility OT - ultrasound imaging COIS- Authors Sergio Garcia-Herreros, Angela Cebria, Pablo Salvador Coloma, Sara Nozal, Jesus Cano and Eduardo Jorge Godoy were employed by the company DAWAKO Medtech S.L. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/06/27 06:42 MHDA- 2024/06/27 06:43 PMCR- 2024/06/08 CRDT- 2024/06/27 01:21 PHST- 2024/04/03 00:00 [received] PHST- 2024/06/05 00:00 [revised] PHST- 2024/06/05 00:00 [accepted] PHST- 2024/06/27 06:43 [medline] PHST- 2024/06/27 06:42 [pubmed] PHST- 2024/06/27 01:21 [entrez] PHST- 2024/06/08 00:00 [pmc-release] AID - nu16121806 [pii] AID - nutrients-16-01806 [pii] AID - 10.3390/nu16121806 [doi] PST - epublish SO - Nutrients. 2024 Jun 8;16(12):1806. doi: 10.3390/nu16121806. PMID- 38926872 OWN - NLM STAT- MEDLINE DCOM- 20240627 LR - 20240629 IS - 1749-8090 (Electronic) IS - 1749-8090 (Linking) VI - 19 IP - 1 DP - 2024 Jun 26 TI - Development and validation of a machine learning predictive model for perioperative myocardial injury in cardiac surgery with cardiopulmonary bypass. PG - 384 LID - 10.1186/s13019-024-02856-y [doi] LID - 384 AB - BACKGROUND: Perioperative myocardial injury (PMI) with different cut-off values has showed to be associated with different prognostic effect after cardiac surgery. Machine learning (ML) method has been widely used in perioperative risk predictions during cardiac surgery. However, the utilization of ML in PMI has not been studied yet. Therefore, we sought to develop and validate the performances of ML for PMI with different cut-off values in cardiac surgery with cardiopulmonary bypass (CPB). METHODS: This was a second analysis of a multicenter clinical trial (OPTIMAL) and requirement for written informed consent was waived due to the retrospective design. Patients aged 18-70 undergoing elective cardiac surgery with CPB from December 2018 to April 2021 were enrolled in China. The models were developed using the data from Fuwai Hospital and externally validated by the other three cardiac centres. Traditional logistic regression (LR) and eleven ML models were constructed. The primary outcome was PMI, defined as the postoperative maximum cardiac Troponin I beyond different times of upper reference limit (40x, 70x, 100x, 130x) We measured the model performance by examining the area under the receiver operating characteristic curve (AUROC), precision-recall curve (AUPRC), and calibration brier score. RESULTS: A total of 2983 eligible patients eventually participated in both the model development (n = 2420) and external validation (n = 563). The CatboostClassifier and RandomForestClassifier emerged as potential alternatives to the LR model for predicting PMI. The AUROC demonstrated an increase with each of the four cutoffs, peaking at 100x URL in the testing dataset and at 70x URL in the external validation dataset. However, it's worth noting that the AUPRC decreased with each cutoff increment. Additionally, the Brier loss score decreased as the cutoffs increased, reaching its lowest point at 0.16 with a 130x URL cutoff. Moreover, extended CPB time, aortic duration, elevated preoperative N-terminal brain sodium peptide, reduced preoperative neutrophil count, higher body mass index, and increased high-sensitivity C-reactive protein levels were identified as risk factors for PMI across all four cutoff values. CONCLUSIONS: The CatboostClassifier and RandomForestClassifer algorithms could be an alternative for LR in prediction of PMI. Furthermore, preoperative higher N-terminal brain sodium peptide and lower high-sensitivity C-reactive protein were strong risk factor for PMI, the underlying mechanism require further investigation. CI - (c) 2024. The Author(s). FAU - Li, Qian AU - Li Q AD - Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Lv, Hong AU - Lv H AD - Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Chen, Yuye AU - Chen Y AD - Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Shen, Jingjia AU - Shen J AD - Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Shi, Jia AU - Shi J AD - Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Zhou, Chenghui AU - Zhou C AD - Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. chenghuizhou@vip.163.com. AD - Center for Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Rd., Chaoyang District, Beijing, 10029, China. chenghuizhou@vip.163.com. LA - eng GR - 81970290/National Outstanding Youth Science Fund Project of National Natural Science Foundation of China/ PT - Journal Article PT - Multicenter Study DEP - 20240626 PL - England TA - J Cardiothorac Surg JT - Journal of cardiothoracic surgery JID - 101265113 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - *Cardiac Surgical Procedures/adverse effects MH - *Cardiopulmonary Bypass/adverse effects MH - China/epidemiology MH - *Machine Learning MH - Postoperative Complications/diagnosis/epidemiology MH - Retrospective Studies MH - Risk Assessment/methods PMC - PMC11201784 OTO - NOTNLM OT - Cardiac surgery OT - Logistic regression OT - Machine learning OT - Perioperative myocardial injury COIS- All authors declare that the research was conducted without any commercial or financial relationships construed as a potential conflict of interest. The authors declare no competing interests. EDAT- 2024/06/27 00:42 MHDA- 2024/06/27 06:43 PMCR- 2024/06/26 CRDT- 2024/06/26 23:52 PHST- 2024/01/02 00:00 [received] PHST- 2024/06/14 00:00 [accepted] PHST- 2024/06/27 06:43 [medline] PHST- 2024/06/27 00:42 [pubmed] PHST- 2024/06/26 23:52 [entrez] PHST- 2024/06/26 00:00 [pmc-release] AID - 10.1186/s13019-024-02856-y [pii] AID - 2856 [pii] AID - 10.1186/s13019-024-02856-y [doi] PST - epublish SO - J Cardiothorac Surg. 2024 Jun 26;19(1):384. doi: 10.1186/s13019-024-02856-y. PMID- 38926238 OWN - NLM STAT- MEDLINE DCOM- 20241121 LR - 20260528 IS - 1869-4098 (Electronic) IS - 1869-408X (Linking) VI - 15 IP - 5 DP - 2024 Oct TI - Three-Dimensional Feature Tracking Study of Healthy Chinese Ventricle by Cardiac Magnetic Resonance. PG - 606-615 LID - 10.1007/s13239-024-00736-z [doi] AB - PURPOSE: Myocardial strain, as a crucial quantitative indicator of myocardial deformation, can detect the changes of cardiac function earlier than parameters such as ejection fraction (EF). It has reported that cardiac magnetic resonance(CMR) and post-processing software possess the ability to obtain the stability and repeatability strain values. Recently, the normal strain values range of people are debatable, especially in the Chinese population. Therefore, we aim to explore the ventricular characteristics and the myocardial strain values of the Chinese people by using the cardiac magnetic resonance feature tracking (CMR-FT). Additionally, we attempted to use the myocardial and chordae tendineae contours to calculate the ventricular volumes by the CMR-FT. This study may provide valuable insights into the application of CMR-FT in tracking the ventricular characteristics and myocardial strain for Chinese population, especially in suggesting an referable myocardial strain parameters of the Chinese. METHODS: A total of 109 healthy Chinese individuals (age range: 18 to 58 years; 52 males and 57 females) underwent 3.0T CMR to acquire the cardiac images. The commercial post-processing software was employed to analyse the image sequence by semi-automatic processing, then the biventricular morphology (End-Diastolic Volume, EDV; EDV/Body Surface Area, EDV/BSA), function(EF; Cardiac Output, CO; Cardiac Index, CI) and strain(Radial Strain, RS; Circumferential Strain, CS; Longitudinal Strain, LS) values were obtained.The biventricular myocardial strain values were stratified according to the age and gender. The Left Ventricular( LV base, mid, apex) and myocardial strain values of three coronary artery areas were calculated based on the the strain value of LV American Heart Association(AHA) 16 segments. RESULTS: It was shown that the females had larger LV globe strain values compared with the males (LVGPRS: 42.0 +/- 8.5 versus 33.6 +/- 6.2%, P < 0.001; LVGPCS: -21.2 +/- 2.1 versus - 19.7 +/- 2.3%, P < 0.001; LVGPLS: -16.4 +/- 2.6 versus - 14.6 +/- 2.2%, P < 0.001;). Moreover, the differences in RS, CS, and LS among the LV myocardium 16 segments were obvious. However, the right ventricle (RV) strain values showed non-normal distribution in the volunteers of this research. CONCLUSIONS: Here, we successfully tracked the characteristics of bilateral ventricles in healthy Chinese populations through using the 3.0T CMR. We confirmed that there was a gender difference in LV Globe Strain values. In addition, we obtained strain values for each myocardial segment of the LV and different coronary artery regions based on the AHA 16 segments method, Our results also showed that the RV strain values with a non-normal distribution, and RV global strain values were not related to the gender and age. Furthermore, LVGPRS, LVGPLS, and RVGPRS were significantly correlated with BMI, CO, CI, and EDV in the Chinese population. CI - (c) 2024. The Author(s) under exclusive licence to Biomedical Engineering Society. FAU - Han, Binze AU - Han B AD - Department of Radiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, Sichuan Province, China. AD - Department of Radiology, Sichuan Provincial People?s Hospital, University of Electronic Science and Technology of China, No. 32, West Section 2, First Ring Road, Chengdu, 610072, Sichuan Province, PR China. FAU - Chen, Shouming AU - Chen S AD - Department of Radiology, Sichuan Provincial People?s Hospital, University of Electronic Science and Technology of China, No. 32, West Section 2, First Ring Road, Chengdu, 610072, Sichuan Province, PR China. FAU - Liu, Li AU - Liu L AD - Department of Radiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, Sichuan Province, China. FAU - Hu, Liuhong AU - Hu L AD - Department of Radiology, Sichuan Provincial People?s Hospital, University of Electronic Science and Technology of China, No. 32, West Section 2, First Ring Road, Chengdu, 610072, Sichuan Province, PR China. FAU - Yin, Longlin AU - Yin L AUID- ORCID: 0000-0003-2064-4586 AD - Department of Radiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, Sichuan Province, China. yinlonglin@163.com. AD - Department of Radiology, Affiliated Hospital of Panzhihua University, Panzhihua, 617000, Sichuan Province, China. yinlonglin@163.com. LA - eng GR - Grant No.2023YFS0227/the Key Research and Development Project of Sichuan Province Science and Technology Department/ GR - Grant No.2023-215/Health Commission of Sichuan Province/ GR - 2021ZD-S-5/Science and Technology Plan Project of Wenzhou Municipality/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240626 PL - United States TA - Cardiovasc Eng Technol JT - Cardiovascular engineering and technology JID - 101531846 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - Biomechanical Phenomena MH - China MH - East Asian People MH - Healthy Volunteers MH - *Heart Ventricles/diagnostic imaging/anatomy & histology MH - Image Interpretation, Computer-Assisted MH - Imaging, Three-Dimensional MH - Magnetic Resonance Imaging MH - Magnetic Resonance Imaging, Cine MH - Myocardial Contraction MH - Predictive Value of Tests MH - Reference Values MH - Reproducibility of Results MH - Stroke Volume MH - *Ventricular Function, Left OTO - NOTNLM OT - Cardiovascular magnetic resonance OT - Normal reference ranges OT - Strain EDAT- 2024/06/27 00:42 MHDA- 2024/11/21 12:26 CRDT- 2024/06/26 23:15 PHST- 2024/01/04 00:00 [received] PHST- 2024/05/24 00:00 [accepted] PHST- 2024/11/21 12:26 [medline] PHST- 2024/06/27 00:42 [pubmed] PHST- 2024/06/26 23:15 [entrez] AID - 10.1007/s13239-024-00736-z [pii] AID - 10.1007/s13239-024-00736-z [doi] PST - ppublish SO - Cardiovasc Eng Technol. 2024 Oct;15(5):606-615. doi: 10.1007/s13239-024-00736-z. Epub 2024 Jun 26. PMID- 38926141 OWN - NLM STAT- MEDLINE DCOM- 20240626 LR - 20250128 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 14 IP - 6 DP - 2024 Jun 26 TI - Digital therapeutics-based lifestyle intervention for gestational diabetes mellitus prevention of high-risk pregnant women: a study protocol for a non-randomised controlled trial. PG - e077336 LID - 10.1136/bmjopen-2023-077336 [doi] LID - e077336 AB - INTRODUCTION: Digital therapeutics have been approved as a treatment aid for various medical conditions and are increasingly prevalent. Despite numerous studies on the potential of digital therapeutic interventions in preventing gestational diabetes mellitus (GDM), there is a critical need for more high-quality, large-scale studies to validate their effectiveness. This need arises from the inconsistencies in results and variations in the quality of previous research. METHODS AND ANALYSIS: We propose a non-randomised controlled trial involving 800 high-risk pregnant women in 6 maternity and child health hospitals in Fujian, China. This study aims to investigate the role and effectiveness of digital therapeutics-based lifestyle intervention in managing the health of pregnant women at high risk for GDM. The study will compare the differences in GDM prevalence, pregnancy weight management and other pregnancy-related health outcomes between pregnant women who received digital therapeutics-based lifestyle intervention and those in the control group. The intervention includes dietary guidance, a personalised physical activity programme and lifestyle improvement strategies delivered through a smartphone app. Primary outcomes include the incidence of GDM at 24-28 weeks gestation and gestational weight gain (GWG). Secondary outcomes comprise improvements in individual lifestyle and risk factors, nutritional issues, implementation outcomes and other pregnancy-related outcomes. ETHICS AND DISSEMINATION SECTION: The trial was approved by the Ethics Committee of Fujian Maternity and Child Health Hospital (approval number: 2023KY046), Jianyang Maternity and Child Health Hospital (approval number: A202401), Fuqing Maternity and Child Health Hospital (approval number: FY2024003), Changting Maternity and Child Health Hospital (approval number: 202401), Datian Maternity and Child Health Hospital (approval number: dtfy202401) and Quanzhou Maternity and Child Health Hospital (approval number: 2024(50)). We will disseminate our findings by publishing articles in leading peer-reviewed journals. TRIAL REGISTRATION NUMBER: ChiCTR2300071496. CI - (c) Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Lin, Lihua AU - Lin L AD - Fujian Maternity and Child Health Hospital, Fuzhou, Fujian, China. FAU - Dong, Jiayi AU - Dong J AD - Fujian Obstetrics and Gynecology Hospital, Fuzhou, Fujian, China. FAU - Wang, Youxin AU - Wang Y AUID- ORCID: 0000-0002-6574-6706 AD - North China University of Science and Technology School of Public Health, Tangshan, Hebei, China. FAU - Song, Libin AU - Song L AD - Fuzhou Comvee Network & Technology Co., Ltd, Fuzhou, Fujian, China. FAU - Ye, Xiaoyan AU - Ye X AD - Fuzhou Comvee Network & Technology Co., Ltd, Fuzhou, Fujian, China. FAU - Chen, Xingying AU - Chen X AD - Fuzhou Comvee Network & Technology Co., Ltd, Fuzhou, Fujian, China. FAU - Miao, Chong AU - Miao C AD - Fujian Maternity and Child Health Hospital, Fuzhou, Fujian, China Lin7390@126.com 68484088@qq.com. FAU - Lin, Juan AU - Lin J AUID- ORCID: 0000-0002-5277-2825 AD - Fujian Maternity and Child Health Hospital, Fuzhou, Fujian, China Lin7390@126.com 68484088@qq.com. LA - eng PT - Clinical Trial Protocol PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240626 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Pregnancy MH - Female MH - *Diabetes, Gestational/prevention & control/therapy MH - China/epidemiology MH - Gestational Weight Gain MH - Life Style MH - Adult MH - Non-Randomized Controlled Trials as Topic MH - Mobile Applications MH - Exercise MH - Pregnancy, High-Risk PMC - PMC11216049 OTO - NOTNLM OT - Cell Phone OT - Diabetes in pregnancy OT - Pregnant Women OT - Public health COIS- Competing interests: None declared. EDAT- 2024/06/27 00:42 MHDA- 2024/06/27 00:43 PMCR- 2024/06/26 CRDT- 2024/06/26 22:43 PHST- 2024/06/27 00:43 [medline] PHST- 2024/06/27 00:42 [pubmed] PHST- 2024/06/26 22:43 [entrez] PHST- 2024/06/26 00:00 [pmc-release] AID - bmjopen-2023-077336 [pii] AID - 10.1136/bmjopen-2023-077336 [doi] PST - epublish SO - BMJ Open. 2024 Jun 26;14(6):e077336. doi: 10.1136/bmjopen-2023-077336. PMID- 38926086 OWN - NLM STAT- MEDLINE DCOM- 20240731 LR - 20260923 IS - 1529-2401 (Electronic) IS - 0270-6474 (Print) IS - 0270-6474 (Linking) VI - 44 IP - 31 DP - 2024 Jul 31 TI - Top-Down Task Goals Induce the Retrieval State. LID - 10.1523/JNEUROSCI.0452-24.2024 [doi] LID - e0452242024 AB - Engaging the retrieval state (Tulving, 1983) impacts processing and behavior (Long and Kuhl, 2019, 2021; Smith et al., 2022), but the extent to which top-down factors-explicit instructions and goals-versus bottom-up factors-stimulus properties such as repetition and similarity-jointly or independently induce the retrieval state is unclear. Identifying the impact of bottom-up and top-down factors on retrieval state engagement is critical for understanding how control of task-relevant versus task-irrelevant brain states influence cognition. We conducted between-subjects recognition memory tasks on male and female human participants in which we varied test phase goals. We recorded scalp electroencephalography and used an independently validated mnemonic state classifier (Long, 2023) to measure retrieval state engagement as a function of top-down task goals (recognize old vs detect new items) and bottom-up stimulus repetition (hits vs correct rejections (CRs)). We find that whereas the retrieval state is engaged for hits regardless of top-down goals, the retrieval state is only engaged during CRs when the top-down goal is to recognize old items. Furthermore, retrieval state engagement is greater for low compared to high confidence hits when the task goal is to recognize old items. Together, these results suggest that top-down demands to recognize old items induce the retrieval state independent from bottom-up factors, potentially reflecting the recruitment of internal attention to enable access of a stored representation. CI - Copyright (c) 2024 the authors. FAU - Smith, Devyn E AU - Smith DE AD - Department of Psychology, University of Virginia, Charlottesville, VA 22904. FAU - Long, Nicole M AU - Long NM AUID- ORCID: 0000-0003-3766-2764 LA - eng GR - R01 NS132872/NS/NINDS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20240731 PL - United States TA - J Neurosci JT - The Journal of neuroscience : the official journal of the Society for Neuroscience JID - 8102140 SB - IM UOF - bioRxiv. 2024 Mar 08:2024.03.04.583353. doi: 10.1101/2024.03.04.583353. PMID: 38496465 MH - Humans MH - Male MH - Female MH - *Goals MH - *Electroencephalography MH - Young Adult MH - Adult MH - *Mental Recall/physiology MH - Recognition, Psychology/physiology MH - Adolescent PMC - PMC11293448 OTO - NOTNLM OT - EEG OT - MVPA OT - brain state OT - encoding OT - retrieval COIS- The authors declare no competing financial interests. EDAT- 2024/06/27 00:42 MHDA- 2024/08/01 00:41 PMCR- 2025/01/31 CRDT- 2024/06/26 22:03 PHST- 2024/03/01 00:00 [received] PHST- 2024/05/28 00:00 [revised] PHST- 2024/06/17 00:00 [accepted] PHST- 2024/08/01 00:41 [medline] PHST- 2024/06/27 00:42 [pubmed] PHST- 2024/06/26 22:03 [entrez] PHST- 2025/01/31 00:00 [pmc-release] AID - JNEUROSCI.0452-24.2024 [pii] AID - jneuro-44-e0452242024 [pii] AID - 10.1523/JNEUROSCI.0452-24.2024 [doi] PST - epublish SO - J Neurosci. 2024 Jul 31;44(31):e0452242024. doi: 10.1523/JNEUROSCI.0452-24.2024. PMID- 38920159 OWN - NLM STAT- MEDLINE DCOM- 20240626 LR - 20240626 IS - 2972-4066 (Electronic) IS - 0304-4602 (Linking) VI - 52 IP - 12 DP - 2023 Dec 28 TI - An augmented reality mobile application for weight estimation in paediatric patients: A prospective single-blinded cross-sectional study. PG - 660-668 LID - 10.47102/annals-acadmedsg.20238 [doi] AB - INTRODUCTION: Determining the exact weight of children is a challenging task during emergency situations. Current guidelines recommend the use of length-based weight-estimating tapes. However, healthcare providers must either always carry the tapes or take time to locate them. Moreover, they may not know how to use them. To address these issues, we developed an augmented reality smartphone application for length-based weight estimation called the Paediatric Augmented Reality Scale (PARS). We evaluated its performance and compared it to that of the Broselow tape (BT) and Paediatric Advanced Weight Prediction in the Emergency Room extra-long and extra-large (PAWPER-XL) tape methods. METHOD: A prospective, single-blinded cross-sectional study was conducted with children aged 1 month to 12 years who visited the emergency department of the tertiary university hospital in Bucheon, South Korea between July 2021 and February 2022. This study aimed to evaluate the measurement agreement and performance of 3 methods: BT, PAWPER-XL and PARS. RESULTS: In all, 1090 participants were enrolled, and 639 (58.6%) were male. The mean age of the participants was 4.1 +/- 2.8 years, with a mean height of 102.7 +/- 21.7 cm and mean weight of 18.8 +/- 9.5 kg. Compared to BT and PAWPER-XL, PARS exhibited lower mean absolute percentage error (9.60%) and root mean square percentage error (3.02%). PARS achieved a higher proportion of weights estimated within 10% of the actual weight (63.21%), outperform-ing BT (57.25%) and PAWPER-XL (62.47%). The intraclass correlation coefficients for the actual and estimated weights of BT, PAWPER-XL and PARS were 0.952, 0.969 and 0.973, respectively (P<0.001). CONCLUSION: PARS exhibited a modestly better performance than BT and PAWPER-XL in estimating body weight. PARS-estimated body weights correlated fairly accurately with the actual body weights. PARS holds potential utility in paediatric emergencies. FAU - Nah, Sangun AU - Nah S AD - Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea. FAU - Choi, Sungwoo AU - Choi S AD - Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea. FAU - Kang, Nayeon AU - Kang N AD - Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea. FAU - Bae, Kyung Yoon AU - Bae KY AD - Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea. FAU - Kim, Ye Rim AU - Kim YR AD - Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea. FAU - Kim, Minsol AU - Kim M AD - Department of Pediatrics, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea. FAU - Moon, Ji Eun AU - Moon JE AD - Department of Biostatistics, Clinical Trial Center, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea. FAU - Han, Sangsoo AU - Han S AD - Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea. LA - eng GR - 10220010/Soonchunhyang University/ GR - 2021R1G1A1006776/Soonchunhyang University Bucheon Hospital Hyangseol/ GR - 2021R1G1A1006776/National Research Foundation of Korea/ PT - Journal Article DEP - 20231228 PL - Singapore TA - Ann Acad Med Singap JT - Annals of the Academy of Medicine, Singapore JID - 7503289 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Child, Preschool MH - Female MH - Prospective Studies MH - Child MH - *Mobile Applications MH - *Body Weight MH - Infant MH - Single-Blind Method MH - *Emergency Service, Hospital MH - Augmented Reality MH - Smartphone MH - Body Height MH - Republic of Korea OTO - NOTNLM OT - Broselow tape OT - augmented reality OT - body weight OT - mobile application OT - paediatrics EDAT- 2024/06/26 12:43 MHDA- 2024/06/26 12:44 CRDT- 2024/06/26 07:12 PHST- 2024/06/26 12:44 [medline] PHST- 2024/06/26 12:43 [pubmed] PHST- 2024/06/26 07:12 [entrez] AID - 10.47102/annals-acadmedsg.20238 [doi] PST - epublish SO - Ann Acad Med Singap. 2023 Dec 28;52(12):660-668. doi: 10.47102/annals-acadmedsg.20238. PMID- 38917947 OWN - NLM STAT- MEDLINE DCOM- 20240906 LR - 20250626 IS - 1541-6100 (Electronic) IS - 0022-3166 (Linking) VI - 154 IP - 9 DP - 2024 Sep TI - Development of a Population-Level Dichotomous Indicator of Minimum Dietary Diversity as a Proxy for Micronutrient Adequacy in Adolescents Aged 10-19 Y in the United States. PG - 2795-2806 LID - S0022-3166(24)00341-9 [pii] LID - 10.1016/j.tjnut.2024.06.002 [doi] AB - BACKGROUND: Diversity is a key component of diet quality and health, but no indicator exists for adolescents under the age of 15 y. OBJECTIVES: To establish a dichotomous indicator for population-level assessment of adolescent dietary diversity as a proxy for micronutrient adequacy. METHODS: We used the probability approach to construct mean probability of adequacy (MPA) of 11 micronutrients from 2 d of 24-h dietary recall data from NHANES, 2007-2018. For each micronutrient, probability of adequacy (PA) was calculated using the best linear unbiased predictor of usual intake. Adolescent dietary diversity score (ADDS) was derived with a maximum score of 10 food groups. Generalized linear mixed models were used to examine associations between ADDS and MPA. Receiver operating characteristic analysis was used to establish a cutoff for minimum dietary diversity for adolescents (MDD-A) using an energy-adjusted logistic model with ADDS predicting MPA > 0.6. RESULTS: PA was >80% for all nutrients except vitamin C (42.1%), folate (65.7%), and calcium (23.8%). Population MPA was 79.4%, and nearly 92% of adolescents had an MPA > 0.6. ADDS was positively associated with MPA, and energy was a significant confounder. The area under the curve was >0.8 on both days with sensitivity and specificity ranging from 0.71 to 0.80. The MDD-A cutoff was calculated as 5.12 and 5.10 food groups on days 1 and 2, respectively. CONCLUSIONS: In U.S. adolescents, the best cutoff for a dichotomous indicator of dietary diversity as a proxy for micronutrient adequacy is 6 food groups in a given day. Future research could validate MDD-A and its associated cutoff for use across country contexts. CI - Copyright (c) 2024 American Society for Nutrition. All rights reserved. FAU - Jenkins, Mica AU - Jenkins M AD - International Micronutrient Malnutrition Prevention and Control (IMMPaCt) Program, Nutrition Branch, Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention (CDC), Atlanta, GA, United States; Nutrition and Health Sciences Doctoral Program, Laney Graduate School, Emory University, Atlanta, GA, United States. Electronic address: mjjenk2@emory.edu. FAU - Jefferds, Maria Elena D AU - Jefferds MED AD - International Micronutrient Malnutrition Prevention and Control (IMMPaCt) Program, Nutrition Branch, Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention (CDC), Atlanta, GA, United States. FAU - Aburto, Nancy J AU - Aburto NJ AD - Food and Nutrition Division, Food and Agriculture Organization, Rome, Italy. FAU - Ramakrishnan, Usha AU - Ramakrishnan U AD - Nutrition and Health Sciences Doctoral Program, Laney Graduate School, Emory University, Atlanta, GA, United States; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States. FAU - Hartman, Terryl J AU - Hartman TJ AD - Nutrition and Health Sciences Doctoral Program, Laney Graduate School, Emory University, Atlanta, GA, United States; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, United States. FAU - Martorell, Reynaldo AU - Martorell R AD - Nutrition and Health Sciences Doctoral Program, Laney Graduate School, Emory University, Atlanta, GA, United States; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States. FAU - Addo, O Yaw AU - Addo OY AD - International Micronutrient Malnutrition Prevention and Control (IMMPaCt) Program, Nutrition Branch, Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention (CDC), Atlanta, GA, United States; Nutrition and Health Sciences Doctoral Program, Laney Graduate School, Emory University, Atlanta, GA, United States; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Research Support, U.S. Gov't, P.H.S. DEP - 20240623 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 RN - 0 (Micronutrients) SB - IM MH - Humans MH - Adolescent MH - *Micronutrients/administration & dosage MH - Female MH - Male MH - United States MH - Child MH - *Diet MH - *Nutrition Surveys MH - Young Adult MH - Nutritional Status OTO - NOTNLM OT - adolescent nutrition OT - dietary assessment OT - food group indicator OT - micronutrient adequacy OT - minimum dietary diversity EDAT- 2024/06/26 00:41 MHDA- 2024/09/07 14:41 CRDT- 2024/06/25 19:17 PHST- 2024/03/06 00:00 [received] PHST- 2024/05/30 00:00 [revised] PHST- 2024/06/07 00:00 [accepted] PHST- 2024/09/07 14:41 [medline] PHST- 2024/06/26 00:41 [pubmed] PHST- 2024/06/25 19:17 [entrez] AID - S0022-3166(24)00341-9 [pii] AID - 10.1016/j.tjnut.2024.06.002 [doi] PST - ppublish SO - J Nutr. 2024 Sep;154(9):2795-2806. doi: 10.1016/j.tjnut.2024.06.002. Epub 2024 Jun 23. PMID- 38917748 OWN - NLM STAT- MEDLINE DCOM- 20240905 LR - 20250103 IS - 1873-491X (Electronic) IS - 0020-7489 (Linking) VI - 158 DP - 2024 Oct TI - Physical activity levels and influencing factors among pregnant women in China: A systematic review and meta-analysis. PG - 104841 LID - S0020-7489(24)00153-6 [pii] LID - 10.1016/j.ijnurstu.2024.104841 [doi] AB - BACKGROUND: Physical activity during pregnancy has been recommended as an effective measure to prevent various pregnancy complications. However, global physical activity participation during pregnancy is not optimal, and the factors influencing physical activity participation during pregnancy need to be further investigated. In China, where there are no localized guidelines for physical activity during pregnancy, the prevalence of meeting recommended physical activity levels among Chinese pregnant women is still unclear. OBJECTIVES: This study aimed to comprehensively review the prevalence of meeting recommended physical activity levels among pregnant women in China and to further explore the factors influencing physical activity participation during pregnancy. DESIGN: This was a systematic review and meta-analysis. METHODS: A systematic review was conducted in both English and Chinese databases from inception until August 1, 2023. Two reviewers independently screened literature, assessed study eligibility and extracted data. The Agency for Healthcare Research and Quality was used to evaluate methodological quality of included studies. The pooled prevalence was calculated using a random-effects model. Subgroup analyses were conducted to explore sources of heterogeneity. RESULTS: A total of 12 cross-sectional studies, including 11,323 Chinese pregnant women with a mean age ranging from 27.0 to 33.0 years, met the inclusion criteria. The prevalence of meeting recommended physical activity levels among pregnant women in China was 21.0 % (95 % confidence interval (CI):12.5 %-29.5 %). A higher prevalence of meeting recommended physical activity levels was observed among pregnant women who were in their second trimester, who were living in the southern region, who were assessed by validated questionnaires, and who used 150 min physical activity per week as a criterion for meeting recommendation. CONCLUSIONS: The findings suggested a low prevalence of meeting recommended physical activity levels among Chinese pregnant women, which was affected by a variety of factors. It is recommended that further research be conducted in the future to explore physical activity intervention strategies for women of childbearing age before and during pregnancy based on the factors affecting physical activity to improve physical activity compliance, maternal and child health and population quality. REGISTRATION NUMBER: CRD42022372722 (PROSPERO). CI - Copyright (c) 2024 Elsevier Ltd. All rights reserved. FAU - Zhang, Wei AU - Zhang W AD - Women's Hospital School of Medicine Zhejiang University, No.1 Xue Shi Road, Hangzhou 310006, Zhejiang Province, China; Zhejiang University School of Medicine, No.866 Yu Hang Tang Road, Hangzhou 310058, Zhejiang Province, China. Electronic address: vivianzhang@zju.edu.cn. FAU - Zhang, Le AU - Zhang L AD - Women's Hospital School of Medicine Zhejiang University, No.1 Xue Shi Road, Hangzhou 310006, Zhejiang Province, China. Electronic address: 5614038@zju.edu.cn. FAU - Xu, Ping AU - Xu P AD - Women's Hospital School of Medicine Zhejiang University, No.1 Xue Shi Road, Hangzhou 310006, Zhejiang Province, China; Zhejiang University School of Medicine, No.866 Yu Hang Tang Road, Hangzhou 310058, Zhejiang Province, China. Electronic address: 1160236396@zju.edu.cn. FAU - Guo, Pingping AU - Guo P AD - Women's Hospital School of Medicine Zhejiang University, No.1 Xue Shi Road, Hangzhou 310006, Zhejiang Province, China; Zhejiang University School of Medicine, No.866 Yu Hang Tang Road, Hangzhou 310058, Zhejiang Province, China. Electronic address: 12118394@zju.edu.cn. FAU - Mao, Minna AU - Mao M AD - Women's Hospital School of Medicine Zhejiang University, No.1 Xue Shi Road, Hangzhou 310006, Zhejiang Province, China; Zhejiang University School of Medicine, No.866 Yu Hang Tang Road, Hangzhou 310058, Zhejiang Province, China. Electronic address: 22118796@zju.edu.cn. FAU - Zhao, Rujia AU - Zhao R AD - Women's Hospital School of Medicine Zhejiang University, No.1 Xue Shi Road, Hangzhou 310006, Zhejiang Province, China; Zhejiang University School of Medicine, No.866 Yu Hang Tang Road, Hangzhou 310058, Zhejiang Province, China. Electronic address: 22218268@zju.edu.cn. FAU - Feng, Suwen AU - Feng S AD - Women's Hospital School of Medicine Zhejiang University, No.1 Xue Shi Road, Hangzhou 310006, Zhejiang Province, China. Electronic address: fengsw@zju.edu.cn. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20240611 PL - England TA - Int J Nurs Stud JT - International journal of nursing studies JID - 0400675 SB - IM MH - Adult MH - Female MH - Humans MH - Pregnancy MH - China/epidemiology MH - *Exercise MH - *Pregnant People OTO - NOTNLM OT - China OT - Meta-analysis OT - Physical activity OT - Pregnant women OT - Prevalence COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/06/26 00:42 MHDA- 2024/09/05 06:42 CRDT- 2024/06/25 18:09 PHST- 2023/08/09 00:00 [received] PHST- 2024/05/21 00:00 [revised] PHST- 2024/06/05 00:00 [accepted] PHST- 2024/09/05 06:42 [medline] PHST- 2024/06/26 00:42 [pubmed] PHST- 2024/06/25 18:09 [entrez] AID - S0020-7489(24)00153-6 [pii] AID - 10.1016/j.ijnurstu.2024.104841 [doi] PST - ppublish SO - Int J Nurs Stud. 2024 Oct;158:104841. doi: 10.1016/j.ijnurstu.2024.104841. Epub 2024 Jun 11. PMID- 38915087 OWN - NLM STAT- MEDLINE DCOM- 20240625 LR - 20240627 IS - 1476-511X (Electronic) IS - 1476-511X (Linking) VI - 23 IP - 1 DP - 2024 Jun 24 TI - Association of serum uric acid with hypertriglyceridemia in children and adolescents: a cross-sectional study. PG - 195 LID - 10.1186/s12944-024-02182-1 [doi] LID - 195 AB - BACKGROUND: Uric acid (UA), a liver-derived metabolite, is intimately tied to metabolic disorders. Although ample research underscores its connection with hypertriglyceridemia (HTG), studies focusing on adolescents remain limited. To fill the gaps in epidemiology,this study focused on analyzing the relationship between the levels of uric acid and HTG in a demographic sample comprising adolescents from the United States. METHODS: In this study, a total of 4,435 participants through the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2020. The exposure variable was serum uric acid (SUA), the effect variable was HTG, and the covariates included demographic, questionnaire, physical examination and laboratory indicators. We utilized weighted logistic regression and meticulous subgroup evaluations to discern the intrinsic link between SUA and HTG. Stratified analyses augmented the validation of this association, while smooth curve fitting probed for potential nonlinear correlations. RESULTS: The study included 4,435 participants. Male adolescents exhibit elevated SUA levels. After adjusting for all variables, the weighted multiple logistic regression model revealed that SUA was positively correlated with HTG risk (OR = 1.006, 95% CI: 1.005-1.007). This relationship was consistent across the three tertiles group of SUA (T1: OR = 1.006 [95% CI: 1.005-1.007]; T2: OR = 1.006 [95% CI: 1.005-1.007]; T3: OR = 1.004 [95% CI: 1.003-1.006]; P for trend < 0.001). Stratified analyses confirmed that the positive correlation between SUA and HTG risk was significant, irrespective of sex, age or race. CONCLUSIONS: In American children and adolescents aged 12 to 18 years, there was a pronounced association between SUA and HTG. SUA could serve as a risk indicator for HTG. It is recommended that children diagnosed with HTG should be regularly tested for SUA levels. In addition, it is recommended that SUA be included in the comprehensive care of children diagnosed with HTG. CI - (c) 2024. The Author(s). FAU - Si, Shang-An AU - Si SA AD - The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Shandong, 250014, China. FAU - Chen, Meng-Qi AU - Chen MQ AD - The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Shandong, 250014, China. FAU - Zhang, Gui-Ju AU - Zhang GJ AD - The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Shandong, 250014, China. 60170068@sdutcm.edu.cn. AD - Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong, 250014, China. 60170068@sdutcm.edu.cn. LA - eng GR - 2019GSF108157/shandong focus on research and development projects/ GR - 2019GSF108157/shandong focus on research and development projects/ GR - 2019GSF108157/shandong focus on research and development projects/ PT - Journal Article DEP - 20240624 PL - England TA - Lipids Health Dis JT - Lipids in health and disease JID - 101147696 RN - 268B43MJ25 (Uric Acid) RN - 0 (Triglycerides) SB - IM MH - Humans MH - *Uric Acid/blood MH - Adolescent MH - *Hypertriglyceridemia/blood/epidemiology MH - Male MH - Female MH - Child MH - Cross-Sectional Studies MH - *Nutrition Surveys MH - Logistic Models MH - Risk Factors MH - United States/epidemiology MH - Triglycerides/blood PMC - PMC11194951 OTO - NOTNLM OT - Adolescent OT - Children OT - Hypertriglyceridemia OT - NHANES OT - Serum uric acid COIS- The authors declare that they have no known competing financial interests or personal relationships that may affect the work reported herein. EDAT- 2024/06/25 00:43 MHDA- 2024/06/25 06:42 PMCR- 2024/06/24 CRDT- 2024/06/24 23:40 PHST- 2023/09/03 00:00 [received] PHST- 2024/06/12 00:00 [accepted] PHST- 2024/06/25 06:42 [medline] PHST- 2024/06/25 00:43 [pubmed] PHST- 2024/06/24 23:40 [entrez] PHST- 2024/06/24 00:00 [pmc-release] AID - 10.1186/s12944-024-02182-1 [pii] AID - 2182 [pii] AID - 10.1186/s12944-024-02182-1 [doi] PST - epublish SO - Lipids Health Dis. 2024 Jun 24;23(1):195. doi: 10.1186/s12944-024-02182-1. PMID- 38914967 OWN - NLM STAT- MEDLINE DCOM- 20240624 LR - 20250128 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 Jun 24 TI - Development and psychometric testing of a questionnaire for the Korea Youth risk behavior survey to assess physical activity behaviors. PG - 1686 LID - 10.1186/s12889-024-19216-z [doi] LID - 1686 AB - BACKGROUND: Physical activity is essential for physical, mental, and cognitive health. Providing evidence to develop better public health policies to encourage increased physical activity is crucial. Therefore, we developed an in-depth survey as part of the Korea Youth Risk Behavior Survey to assess the current status and determinants of physical activity among Korean adolescents. METHODS: We developed an initial version of the questionnaire based on a review of validated questionnaires, recent trends and emerging issues related to adolescent physical activity, and the national public health agenda pertaining to health promotion. Content validity was confirmed by a panel of 10 experts. Face validity was confirmed through focus group interviews with 12 first-year middle school students. The test-retest reliability of the questionnaire was evaluated by administering it twice, approximately two weeks apart, to a sample of 360 middle and high school students. Additionally, the frequency or average number of responses was analyzed in a sample of 600 students who participated in the initial test-retest reliability evaluation of the questionnaire developed in this study. RESULTS: Through item pool generation and content and face validity test, the final 15 questionnaire items were developed across five themes: levels of physical activity, school sports club activities, transportation-related physical activity, physical activity-promoting environments, and factors mediating physical activity. The test-retest reliability ranged from fair to substantial. Results from the newly developed survey reveal that only a minority of adolescents engage in sufficient physical activity, with only 17.2% and 21.5% participating in vigorous and moderate-intensity activities, respectively, for at least five days per week. Among school-based activities, 44.3% of students do not participate in school sports clubs due to reasons including absence of clubs and disinterest in exercise. The major motivators for physical activity are personal enjoyment and health benefits, whereas preferences for other leisure activities and academic pressures are the predominant barriers. CONCLUSIONS: This study developed valid and reliable in-depth survey items to assess physical activity among Korean youths. It will hopefully enhance our understanding of adolescent physical activity, offering essential preliminary evidence to inform the development of public health strategies aimed at promoting adolescent health. CI - (c) 2024. The Author(s). FAU - Park, Bomi AU - Park B AD - Department of Preventive Medicine, College of Medicine, Chung-Ang University, Seoul, Korea. FAU - Lee, Hye Ah AU - Lee HA AD - Clinical Trial Center, Ewha Womans University Mokdong Hospital, Seoul, Korea. FAU - Shin, Yoonhee AU - Shin Y AD - Advanced Biomedical Research Institute, Ewha Womans University Seoul Hospital and College of Nursing, Ewha Womans University, Seoul, Korea. AD - College of Nursing, Ewha Womans University, Seoul, Korea. FAU - Kim, Yeonjae AU - Kim Y AD - Department of Preventive Medicine, College of Medicine, Chung-Ang University, Seoul, Korea. FAU - Park, Hyunjin AU - Park H AD - Department of Preventive Medicine, College of Medicine, Ewha Womans University, Seoul, Korea. AD - Graduate Program in System Health Science and Engineering, Ewha Womans University, Seoul, Korea. FAU - Jun, Seunghee AU - Jun S AD - Department of Preventive Medicine, College of Medicine, Ewha Womans University, Seoul, Korea. AD - Graduate Program in System Health Science and Engineering, Ewha Womans University, Seoul, Korea. FAU - Kim, Ui Jeong AU - Kim UJ AD - Department of Preventive Medicine, College of Medicine, Ewha Womans University, Seoul, Korea. FAU - Oh, Kyungwon AU - Oh K AD - Division of Health and Nutrition Survey and Analysis, Bureau of Chronic Disease Prevention and Control, Korea Disease Control and Prevention Agency, Cheongju, Korea. FAU - Choi, Sunhye AU - Choi S AD - Division of Health and Nutrition Survey and Analysis, Bureau of Chronic Disease Prevention and Control, Korea Disease Control and Prevention Agency, Cheongju, Korea. FAU - Kim, Yangha AU - Kim Y AD - Division of Health and Nutrition Survey and Analysis, Bureau of Chronic Disease Prevention and Control, Korea Disease Control and Prevention Agency, Cheongju, Korea. FAU - Park, Hyesook AU - Park H AD - Department of Preventive Medicine, College of Medicine, Ewha Womans University, Seoul, Korea. hpark@ewha.ac.kr. AD - Graduate Program in System Health Science and Engineering, Ewha Womans University, Seoul, Korea. hpark@ewha.ac.kr. LA - eng GR - 2022-11-009/Korea Disease Control and Prevention Agency/ GR - 2022-11-009/Korea Disease Control and Prevention Agency/ GR - 2022-11-009/Korea Disease Control and Prevention Agency/ GR - 2022-11-009/Korea Disease Control and Prevention Agency/ GR - 2022-11-009/Korea Disease Control and Prevention Agency/ GR - 2022-11-009/Korea Disease Control and Prevention Agency/ GR - 2022-11-009/Korea Disease Control and Prevention Agency/ GR - 2022-11-009/Korea Disease Control and Prevention Agency/ GR - NRF-5199990614253/BK21 FOUR (Fostering Outstanding Universities for Research), funded by the Ministry of Education (South Korea) and the National Research Foundation of Korea/ GR - NRF-5199990614253/BK21 FOUR (Fostering Outstanding Universities for Research), funded by the Ministry of Education (South Korea) and the National Research Foundation of Korea/ GR - NRF-5199990614253/BK21 FOUR (Fostering Outstanding Universities for Research), funded by the Ministry of Education (South Korea) and the National Research Foundation of Korea/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20240624 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Adolescent MH - Surveys and Questionnaires/standards MH - Republic of Korea MH - Male MH - Female MH - *Psychometrics MH - Reproducibility of Results MH - Risk-Taking MH - Exercise/psychology MH - Focus Groups MH - Adolescent Behavior/psychology MH - Motor Activity PMC - PMC11197320 OTO - NOTNLM OT - Adolescent OT - Exercise OT - Questionnaire OT - Reliability OT - Survey OT - Validity COIS- The authors declare no competing interests. EDAT- 2024/06/25 00:43 MHDA- 2024/06/25 00:44 PMCR- 2024/06/24 CRDT- 2024/06/24 23:34 PHST- 2024/02/13 00:00 [received] PHST- 2024/06/20 00:00 [accepted] PHST- 2024/06/25 00:44 [medline] PHST- 2024/06/25 00:43 [pubmed] PHST- 2024/06/24 23:34 [entrez] PHST- 2024/06/24 00:00 [pmc-release] AID - 10.1186/s12889-024-19216-z [pii] AID - 19216 [pii] AID - 10.1186/s12889-024-19216-z [doi] PST - epublish SO - BMC Public Health. 2024 Jun 24;24(1):1686. doi: 10.1186/s12889-024-19216-z. PMID- 38913614 OWN - NLM STAT- MEDLINE DCOM- 20240624 LR - 20260805 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 6 DP - 2024 TI - Relative contribution of biomedical, demographic, and socioeconomic factors to COVID-19 vaccine receipt in rural India. PG - e0305819 LID - 10.1371/journal.pone.0305819 [doi] LID - e0305819 AB - BACKGROUND: In the first year of roll-out, vaccination for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prevented almost 20 million deaths from coronavirus disease 2019 (COVID-19). Yet, little is known about the factors influencing access to vaccination at the individual level within rural poor settings of low-income countries. The aim of this study was to examine determinants of vaccine receipt in rural India. METHODS: A census of a rural village in Tamil Nadu was undertaken from June 2021 to September 2022. We surveyed 775 participants from 262 households. Household-level data on socioeconomic status (SES), water, sanitation, and hygiene practices, and individual-level demographic information, travel history, and biomedical data, including anthropometry, vital signs, and comorbidities, were collected. Logistic regression models with 5-fold cross-validation were used to identify the biomedical, demographic, and socioeconomic determinants of vaccine receipt and the timing of receipt within the first 30 days of eligibility. Vaccine ineligible participants were excluded leaving 659 eligible participants. There were 650 eligible participants with complete biomedical, demographic, and socioeconomic data. RESULTS: There were 68.0% and 34.0% of individuals (N = 650) who had received one and two vaccine doses, respectively. Participants with household ownership of a permanent account number (PAN) or ration card were 2.15 (95% CI:1.32-3.52) or 3.02 (95% CI:1.72-5.29) times more likely to receive at least one vaccine dose compared to households with no ownership of such cards. Participants employed as housewives or self-employed non-agricultural workers were 65% (95% CI:0.19-0.67) or 59% (95% CI:0.22-0.76) less likely to receive at least one vaccine dose compared to salaried workers. Household PAN card ownership, occupation and age were linked to the timing of vaccine receipt. Participants aged /= 35 kg/m(2)) and hypertension, type 2 diabetes, metabolic syndrome or OSA or obesity grade III or IV (BMI >/= 40 kg/m(2)) elective for bariatric surgery. Patients were evaluated at the Otorhinolaryngology department with an anamnesis regarding OSA including the administration of three sleep questionnaires (EDSS, ESS, and STOP-Bang), followed by cardiorespiratory polygraphy (CRP) for sleep evaluation. RESULTS: 124 patients were included in this study. While 74.2% of the sample exhibited OSA on CRP, only 28.2% had a prior diagnosis. The STOP-Bang questionnaire demonstrated the highest sensitivity (93.3%) for detecting moderate to severe OSA, although with low specificity (33.8%). EDSS and ESS did not show a significant association with the presence of OSA. CONCLUSIONS: OSA screening is crucial in candidates for bariatric surgery due to its high prevalence and low diagnosis rate. The STOP-Bang questionnaire may serve as a useful tool for identifying patients at risk of moderate to severe OSA and optimizing sleep assessments. However, further research is necessary to validate its utility in this specific population. CI - Copyright (c) 2024 Sociedad Espanola de Otorrinolaringologia y Cirugia de Cabeza y Cuello. Published by Elsevier Espana, S.L.U. All rights reserved. FAU - Matarredona Quiles, Silvia AU - Matarredona Quiles S AD - Deparment of Otolaryngology, head and neck surgery, Hospital Universitario Doctor Peset, Valencia, Spain. Electronic address: matarredona_sil@gva.es. FAU - Carrasco Llatas, Marina AU - Carrasco Llatas M AD - Deparment of Otolaryngology, head and neck surgery, Hospital Universitario Doctor Peset, Valencia, Spain. FAU - Martinez Ruiz de Apodaca, Paula AU - Martinez Ruiz de Apodaca P AD - Deparment of Otolaryngology, head and neck surgery, Hospital Universitario Doctor Peset, Valencia, Spain. FAU - Diez Ares, Jose Angel AU - Diez Ares JA AD - Department of geneal and digestive surgery, Hospital Universitario Doctor Peset, Valencia, Spain. FAU - Navarro Martinez, Sergio AU - Navarro Martinez S AD - Department of geneal and digestive surgery, Hospital Universitario Doctor Peset, Valencia, Spain. FAU - Dalmau Galofre, Jose AU - Dalmau Galofre J AD - Deparment of Otolaryngology, head and neck surgery, Hospital Universitario Doctor Peset, Valencia, Spain. LA - eng PT - Journal Article DEP - 20240620 PL - Spain TA - Acta Otorrinolaringol Esp (Engl Ed) JT - Acta otorrinolaringologica espanola JID - 101770938 SB - IM MH - Humans MH - *Sleep Apnea, Obstructive/epidemiology/diagnosis MH - *Bariatric Surgery MH - Adult MH - Middle Aged MH - Male MH - Female MH - Prospective Studies MH - Prevalence MH - Surveys and Questionnaires MH - Young Adult MH - Obesity/complications/epidemiology MH - Adolescent MH - Aged MH - Longitudinal Studies OTO - NOTNLM OT - Apnea obstructiva del sueno OT - Bariatric surgery OT - Cirugia bariatrica OT - Cuestionarios de sueno OT - Morbid obesity OT - Obesidad morbida OT - Obstructive sleep apnea OT - Sleep questionnaires EDAT- 2024/06/23 00:42 MHDA- 2024/11/18 00:31 CRDT- 2024/06/22 19:31 PHST- 2024/02/12 00:00 [received] PHST- 2024/05/10 00:00 [accepted] PHST- 2024/11/18 00:31 [medline] PHST- 2024/06/23 00:42 [pubmed] PHST- 2024/06/22 19:31 [entrez] AID - S2173-5735(24)00065-6 [pii] AID - 10.1016/j.otoeng.2024.06.001 [doi] PST - ppublish SO - Acta Otorrinolaringol Esp (Engl Ed). 2024 Nov-Dec;75(6):354-360. doi: 10.1016/j.otoeng.2024.06.001. Epub 2024 Jun 20. PMID- 38907225 OWN - NLM STAT- MEDLINE DCOM- 20240621 LR - 20240624 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 23 IP - 1 DP - 2024 Jun 21 TI - Assessing the relative validity of a web-based self-administered 24-hour dietary recall in a Canadian adolescent's population. PG - 66 LID - 10.1186/s12937-024-00954-0 [doi] LID - 66 AB - BACKGROUND: Healthy eating habits at a young age are crucial to support growth and development and good general health. In this context, monitoring youth dietary intakes adequately with valid tools is important to develop efficient interventions and identify groups that are more at risk of inadequate intakes. This study aimed to assess the relative validity of the self-administered web-based 24-h dietary recall (R24W) for evaluating energy and nutrient intakes among active adolescents. METHODS: Participants were invited to complete one interviewer-administered 24-h dietary dietary recall and the R24W on up to three occasions within one month. A total of 272 French-speaking active adolescents aged 12 to 17 years from the province of Quebec were invited to complete three R24W and one interview-administered 24-h recall. Student's t-test and correlations were conducted on sex-adjusted data. Percent differences, cross-classification (percentage of agreement), weighted Kappa and Bland-Altman plots were calculated. RESULTS: Mean (SD) energy intake from the R24W was 8.8% higher than from the interview-administered 24-h dietary recall (2558 kcal +/- 1128 vs. 2444 kcal +/- 998, p < 0.05). Significant differences in mean nutrient intake between the R24W and the interview-administered 24-h dietary recall ranged from 6.5% for % E from fat (p < 0.05) to 25.2% for saturated fat (p < 0.001), i.e., higher values with R24W. Sex-adjusted correlations were significant for all nutrients except for % E from proteins and thiamin (range: 0.24 to 0.52, p < 0.01). Cross-classification demonstrated that 36.6% of the participants were classified in the same fourth with both methods, 39.6% in the adjacent fourth, and 5.7% misclassified. Bland-Atman plots revealed proportional bias between the two methods for 7/25 nutrients. Completing at least two recalls with the R24W increased the precision of intake estimates. CONCLUSION: These data suggest that the R24W presents an acceptable relative validity compared to a standard interview-administered 24-h recall for estimating energy and most nutrients in a cohort of French-speaking adolescents from the province of Quebec. CI - (c) 2024. Crown. FAU - Drapeau, Vicky AU - Drapeau V AUID- ORCID: 0000-0002-3061-691X AD - Department of Kinesiology, Faculty of Medicine, Universite Laval Quebec, 2300, rue de la Terrasse, G1V 0A6, Quebec, Canada. vicky.drapeau@kin.ulaval.ca. AD - Centre Nutrition, Sante et Societe (NUTRISS), Institut sur la nutrition et les aliments fonctionnels (INAF), Universite Laval, G1V 0A6, Quebec, Canada. vicky.drapeau@kin.ulaval.ca. AD - Quebec Heart and Lung Institute Research Center, Universite Laval, G1V 4G5, Quebec, Canada. vicky.drapeau@kin.ulaval.ca. FAU - Laramee, Catherine AU - Laramee C AD - Centre Nutrition, Sante et Societe (NUTRISS), Institut sur la nutrition et les aliments fonctionnels (INAF), Universite Laval, G1V 0A6, Quebec, Canada. FAU - Lafreniere, Jacynthe AU - Lafreniere J AD - School of Nutrition, Laval University, Quebec, G1V 0A6, Canada. FAU - Trottier, Christiane AU - Trottier C AD - Department of Kinesiology, Faculty of Medicine, Universite Laval Quebec, 2300, rue de la Terrasse, G1V 0A6, Quebec, Canada. FAU - Brochu, Charlotte AU - Brochu C AD - Department of Kinesiology, Faculty of Medicine, Universite Laval Quebec, 2300, rue de la Terrasse, G1V 0A6, Quebec, Canada. AD - Centre Nutrition, Sante et Societe (NUTRISS), Institut sur la nutrition et les aliments fonctionnels (INAF), Universite Laval, G1V 0A6, Quebec, Canada. AD - Quebec Heart and Lung Institute Research Center, Universite Laval, G1V 4G5, Quebec, Canada. FAU - Robitaille, Julie AU - Robitaille J AD - School of Nutrition, Laval University, Quebec, G1V 0A6, Canada. AD - Centre Nutrition, Sante et Societe (NUTRISS), Institut sur la nutrition et les aliments fonctionnels (INAF), Universite Laval, G1V 0A6, Quebec, Canada. FAU - Lamarche, Benoit AU - Lamarche B AD - School of Nutrition, Laval University, Quebec, G1V 0A6, Canada. AD - Centre Nutrition, Sante et Societe (NUTRISS), Institut sur la nutrition et les aliments fonctionnels (INAF), Universite Laval, G1V 0A6, Quebec, Canada. FAU - Lemieux, Simone AU - Lemieux S AD - School of Nutrition, Laval University, Quebec, G1V 0A6, Canada. AD - Centre Nutrition, Sante et Societe (NUTRISS), Institut sur la nutrition et les aliments fonctionnels (INAF), Universite Laval, G1V 0A6, Quebec, Canada. LA - eng GR - 862-2016-0003/Social Sciences and Humanities Research Council of Canada/ GR - 862-2016-0003/Social Sciences and Humanities Research Council of Canada/ PT - Journal Article PT - Validation Study DEP - 20240621 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - *Mental Recall MH - Quebec MH - Child MH - *Internet MH - Reproducibility of Results MH - *Energy Intake MH - Diet/methods/statistics & numerical data MH - Diet Surveys/methods MH - Nutrition Assessment MH - Feeding Behavior MH - Diet Records PMC - PMC11191218 OTO - NOTNLM OT - 24-hour dietary recall OT - Adolescent OT - Energy intake OT - Nutrient intakes OT - Relative validity COIS- BL, JR, SL, and CL were involved in developing the R24W. VD has received funding from Danone and Dairy Farmers of Canada (DFC). JR is Chair of Nutrition at Universite Laval, supported by private endowments from Pfizer, La Banque Royale du Canada, and Provigo-Loblaws. BL has received funding from Health Canada (completed in 2021). All other authors declare no conflicts of interest. EDAT- 2024/06/22 05:43 MHDA- 2024/06/22 05:44 PMCR- 2024/06/21 CRDT- 2024/06/21 23:32 PHST- 2023/06/28 00:00 [received] PHST- 2024/04/28 00:00 [accepted] PHST- 2024/06/22 05:44 [medline] PHST- 2024/06/22 05:43 [pubmed] PHST- 2024/06/21 23:32 [entrez] PHST- 2024/06/21 00:00 [pmc-release] AID - 10.1186/s12937-024-00954-0 [pii] AID - 954 [pii] AID - 10.1186/s12937-024-00954-0 [doi] PST - epublish SO - Nutr J. 2024 Jun 21;23(1):66. doi: 10.1186/s12937-024-00954-0. PMID- 38902763 OWN - NLM STAT- MEDLINE DCOM- 20250130 LR - 20250211 IS - 1748-5908 (Electronic) IS - 1748-5908 (Linking) VI - 19 IP - 1 DP - 2024 Jun 20 TI - Integrated Measure of PRogram Element SuStainability in Childcare Settings (IMPRESS-C): development and psychometric evaluation of a measure of sustainability determinants in the early childhood education and care setting. PG - 41 LID - 10.1186/s13012-024-01372-w [doi] LID - 41 AB - BACKGROUND: There is a need for valid and reliable measures of determinants of sustainability of public health interventions in early childhood education and care (ECEC) settings. This study aimed to develop and evaluate the psychometric and pragmatic properties of such a measure - the Integrated Measure of PRogram Element SuStainability in Childcare Settings (IMPRESS-C). METHODS: We undertook a two-phase process guided by the COnsensus-based Standards for the selection of health status Measurement INstruments checklist (COSMIN) and Psychometric and Pragmatic Evidence Rating Scale (PAPERS). Phase 1 involved measure development; i.e., determining items and scales through an iterative process and assessment of face and content validity. Phase 2 involved the evaluation of psychometric and pragmatic properties. The 29-item measure completed by service executives (directors and nominated supervisors) was embedded in a larger survey from a national sample of Australian ECEC services assessing their implementation of nutrition and physical activity programs. Structural validity, concurrent validity, known groups validity, internal consistency, floor and ceiling effects, norms, and pragmatic qualities of the measure were assessed according to the PAPERS criteria. RESULTS: The final measure contained 26 items, with respondents reporting how strongly they agreed or disagreed on a five-point Likert scale. Phase 1 assessments confirmed the relevance, and face and content validity of the scale. In Phase 2, we obtained 482 completed surveys, of which 84% (n = 405) completed the entire measure across 405 ECEC settings (one executive per service). Three of the four fit indices for the confirmatory factor analysis met the pre-specified criteria (SRMR = 0.056, CFI = 0.993, RMSEA = 0.067) indicating 'good' structural validity. The IMPRESS-C illustrated: 'good' internal consistency, with Cronbach's alpha values from 0.53 to 0.92; 'emerging' concurrent validity; 'poor' known groups validity; 'good' norms; and 'good' overall pragmatic qualities (cost, readability, length, and assessor burden). CONCLUSIONS: The IMPRESS-C possesses strong psychometric and pragmatic qualities for assessing service executive-level perceptions of determinants influencing sustainment of public health interventions within ECEC settings. To achieve a full range of perspectives in this setting, future work should be directed to also develop and test measures of sustainability determinants at the implementer level (e.g., among individual educators and staff). CI - (c) 2024. The Author(s). FAU - Shoesmith, Adam AU - Shoesmith A AUID- ORCID: 0000-0002-3105-8833 AD - School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, 2308, Australia. Adam.Shoesmith@health.nsw.gov.au. AD - Hunter New England Population Health, Hunter New England Local Health District, Newcastle, NSW, 2287, Australia. Adam.Shoesmith@health.nsw.gov.au. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. Adam.Shoesmith@health.nsw.gov.au. AD - National Centre of Implementation Science, University of Newcastle, Callaghan, NSW, 2308, Australia. Adam.Shoesmith@health.nsw.gov.au. FAU - Nathan, Nicole AU - Nathan N AD - School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, 2308, Australia. AD - Hunter New England Population Health, Hunter New England Local Health District, Newcastle, NSW, 2287, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. AD - National Centre of Implementation Science, University of Newcastle, Callaghan, NSW, 2308, Australia. FAU - Lum, Melanie AU - Lum M AD - School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, 2308, Australia. AD - Hunter New England Population Health, Hunter New England Local Health District, Newcastle, NSW, 2287, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. AD - Faculty of Health, School of Health and Social Development, Global Centre for Preventive Health and Nutrition, Institute for Health Transformation, Deakin University, Geelong, VIC, 3220, Australia. AD - National Centre of Implementation Science, University of Newcastle, Callaghan, NSW, 2308, Australia. FAU - Yoong, Serene AU - Yoong S AD - School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, 2308, Australia. AD - Hunter New England Population Health, Hunter New England Local Health District, Newcastle, NSW, 2287, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. AD - Faculty of Health, School of Health and Social Development, Global Centre for Preventive Health and Nutrition, Institute for Health Transformation, Deakin University, Geelong, VIC, 3220, Australia. AD - National Centre of Implementation Science, University of Newcastle, Callaghan, NSW, 2308, Australia. FAU - Nolan, Erin AU - Nolan E AD - School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, 2308, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. AD - National Centre of Implementation Science, University of Newcastle, Callaghan, NSW, 2308, Australia. FAU - Wolfenden, Luke AU - Wolfenden L AD - School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, 2308, Australia. AD - Hunter New England Population Health, Hunter New England Local Health District, Newcastle, NSW, 2287, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. AD - National Centre of Implementation Science, University of Newcastle, Callaghan, NSW, 2308, Australia. FAU - Shelton, Rachel C AU - Shelton RC AD - Department of Sociomedical Sciences, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA. FAU - Cooper, Brittany AU - Cooper B AD - Department of Human Development, Washington State University, Pullman, WA, 99164, USA. FAU - Lane, Cassandra AU - Lane C AD - School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, 2308, Australia. AD - Hunter New England Population Health, Hunter New England Local Health District, Newcastle, NSW, 2287, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. AD - National Centre of Implementation Science, University of Newcastle, Callaghan, NSW, 2308, Australia. FAU - Grady, Alice AU - Grady A AD - School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, 2308, Australia. AD - Hunter New England Population Health, Hunter New England Local Health District, Newcastle, NSW, 2287, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. AD - National Centre of Implementation Science, University of Newcastle, Callaghan, NSW, 2308, Australia. FAU - Imad, Noor AU - Imad N AD - Hunter New England Population Health, Hunter New England Local Health District, Newcastle, NSW, 2287, Australia. AD - Faculty of Health, School of Health and Social Development, Global Centre for Preventive Health and Nutrition, Institute for Health Transformation, Deakin University, Geelong, VIC, 3220, Australia. AD - School of Health Sciences, Department of Nursing and Allied Health, Swinburne University of Technology, Hawthorn, VIC, 3122, Australia. AD - National Centre of Implementation Science, University of Newcastle, Callaghan, NSW, 2308, Australia. FAU - Riley-Gibson, Edward AU - Riley-Gibson E AD - School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, 2308, Australia. AD - Hunter New England Population Health, Hunter New England Local Health District, Newcastle, NSW, 2287, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. AD - National Centre of Implementation Science, University of Newcastle, Callaghan, NSW, 2308, Australia. FAU - McCarthy, Nicole AU - McCarthy N AD - School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, 2308, Australia. AD - Hunter New England Population Health, Hunter New England Local Health District, Newcastle, NSW, 2287, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. AD - National Centre of Implementation Science, University of Newcastle, Callaghan, NSW, 2308, Australia. FAU - Pearson, Nicole AU - Pearson N AD - School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, 2308, Australia. AD - Hunter New England Population Health, Hunter New England Local Health District, Newcastle, NSW, 2287, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. AD - National Centre of Implementation Science, University of Newcastle, Callaghan, NSW, 2308, Australia. FAU - Hall, Alix AU - Hall A AD - School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, 2308, Australia. AD - Hunter New England Population Health, Hunter New England Local Health District, Newcastle, NSW, 2287, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. AD - National Centre of Implementation Science, University of Newcastle, Callaghan, NSW, 2308, Australia. LA - eng GR - APP1197022/National Health and Medical Research Council/ GR - APP1194785/National Health and Medical Research Council/ GR - DE170100382/Australia Research Council Discovery Early Career Research Awards/ GR - RSG-17-156-01-CPPB/American Cancer Society/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240620 PL - England TA - Implement Sci JT - Implementation science : IS JID - 101258411 SB - IM MH - Humans MH - Child MH - *Child Care MH - *Education MH - *Psychometrics/methods MH - Surveys and Questionnaires MH - Cross-Sectional Studies PMC - PMC11188265 OTO - NOTNLM OT - Development OT - Early childhood education and care OT - Measurement OT - Reliability OT - Sustainability OT - Sustainment OT - Validity COIS- The authors declare that they have no competing interests. EDAT- 2024/06/21 00:42 MHDA- 2024/06/21 06:41 PMCR- 2024/06/20 CRDT- 2024/06/20 23:40 PHST- 2023/08/02 00:00 [received] PHST- 2024/06/13 00:00 [accepted] PHST- 2024/06/21 06:41 [medline] PHST- 2024/06/21 00:42 [pubmed] PHST- 2024/06/20 23:40 [entrez] PHST- 2024/06/20 00:00 [pmc-release] AID - 10.1186/s13012-024-01372-w [pii] AID - 1372 [pii] AID - 10.1186/s13012-024-01372-w [doi] PST - epublish SO - Implement Sci. 2024 Jun 20;19(1):41. doi: 10.1186/s13012-024-01372-w. PMID- 38901945 OWN - NLM STAT- MEDLINE DCOM- 20240620 LR - 20260723 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 62 DP - 2024 Aug TI - Maternal gluten, cereal, and dietary fiber intake during pregnancy and lactation and the risk of islet autoimmunity and type 1 diabetes in the child. PG - 22-27 LID - S2405-4577(24)00116-5 [pii] LID - 10.1016/j.clnesp.2024.05.001 [doi] AB - BACKGROUND & AIMS: Maternal gluten intake in relation to child's risk of type 1 diabetes has been studied in few prospective studies considering the diet during pregnancy but none during lactation. Our aim was to study whether gluten, cereals, or dietary fiber in maternal diet during pregnancy and lactation is associated with the risk of islet autoimmunity or type 1 diabetes in the offspring. METHODS: We included 4943 children with genetic susceptibility to type 1 diabetes from the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Study, born between 1996 and 2004. Maternal intake of gluten, different types of cereals, and dietary fiber were derived from a semi-quantitative validated food frequency questionnaire covering the eighth month of pregnancy and the third month of lactation. Children were monitored for islet autoantibodies up to age of 15 years and type 1 diabetes until year 2017. Risk of islet autoimmunity and clinical type 1 diabetes were estimated using Cox regression model, adjusted for energy intake, child's sex, HLA genotype, and familial diabetes. RESULTS: Altogether 312 children (6.4%) developed islet autoimmunity at median age of 3.5 (IQR 1.7, 6.6) years and 178 children (3.6%) developed type 1 diabetes at median age of 7.1 (IQR 4.3, 10.6) years. Gluten intake during pregnancy was not associated with islet autoimmunity (HR 0.96; 95% CI 0.68, 1.35), per 1 g/MJ increase in intake nor type 1 diabetes (HR 0.96; 95% CI 0.62, 1.50) in the offspring. Higher barley consumption during lactation was associated with increased risk of type 1 diabetes (HR 3.25; 95% CI 1.21, 8.70) per 1 g/MJ increase in intake. Maternal intake of other cereals or dietary fiber was not associated with the offspring outcomes. CONCLUSIONS: We observed no association between maternal intake of gluten, most consumed cereals, or dietary fiber during pregnancy or lactation and the risk of islet autoimmunity or type 1 diabetes in children from a high-risk population. CI - Copyright (c) 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Hakola, Leena AU - Hakola L AD - Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, Finland; Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Finland; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland. Electronic address: leena.hakola@tuni.fi. FAU - Lund-Blix, Nicolai A AU - Lund-Blix NA AD - Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland; Norwegian Institute of Public Health, Oslo, Norway; Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Norway. FAU - Takkinen, Hanna-Mari AU - Takkinen HM AD - Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, Finland; Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Finland; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland. FAU - Tapanainen, Heli AU - Tapanainen H AD - Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland. FAU - Niinisto, Sari AU - Niinisto S AD - Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland. FAU - Korhonen, Tuuli E AU - Korhonen TE AD - Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland. FAU - Stene, Lars C AU - Stene LC AD - Norwegian Institute of Public Health, Oslo, Norway. FAU - Hyoty, Heikki AU - Hyoty H AD - Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Fimlab Laboratories, Tampere, Finland; Tampere University Hospital, Department of Pediatrics, Tampere, Finland. FAU - Toppari, Jorma AU - Toppari J AD - Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, and Centre for Population Health Research, University of Turku, Turku, Finland; Turku University Hospital, Department of Pediatrics, Turku, Finland. FAU - Ilonen, Jorma AU - Ilonen J AD - Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland. FAU - Knip, Mikael AU - Knip M AD - Tampere University Hospital, Department of Pediatrics, Tampere, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland. FAU - Veijola, Riitta AU - Veijola R AD - Department of Paediatrics, Research Unit of Clinical Medicine, Medical Research Centre, University of Oulu, Oulu, Finland; Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland. FAU - Virtanen, Suvi M AU - Virtanen SM AD - Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, Finland; Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Finland; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland. CN - HEDIMED Investigator group LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240511 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 RN - 0 (Dietary Fiber) RN - 8002-80-0 (Glutens) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/immunology MH - Female MH - Pregnancy MH - *Dietary Fiber MH - *Glutens/adverse effects MH - Child MH - *Autoimmunity MH - *Lactation MH - *Edible Grain MH - Child, Preschool MH - Male MH - Finland MH - Infant MH - Risk Factors MH - Diet MH - Adolescent MH - Maternal Nutritional Physiological Phenomena MH - Prospective Studies MH - Islets of Langerhans/immunology MH - Prenatal Exposure Delayed Effects MH - Adult OTO - NOTNLM OT - Cohort study OT - Diabetes mellitus, Type 1 OT - Dietary intake OT - Gluten OT - Pregnancy OT - Prenatal exposure delayed effects COIS- Declaration of competing interest Authors declare no conflicts of interest. FIR - Anna, Euren IR - Anna E FIR - Heikki, Hyoty IR - Heikki H FIR - Kalle, Kurppa IR - Kalle K FIR - Jutta, Laiho IR - Jutta L FIR - Olli, Laitinen IR - Olli L FIR - Jussi, Lehtonen IR - Jussi L FIR - Katri, Lindfors IR - Katri L FIR - Maria, Lonnrot IR - Maria L FIR - Johannes, Malkamaki IR - Johannes M FIR - Noora, Nurminen IR - Noora N FIR - Matti, Nykter IR - Matti N FIR - Sami, Oikarinen IR - Sami O FIR - Leena, Puustinen IR - Leena P FIR - Amirbabak, Sioofy-Khojine IR - Amirbabak SK FIR - Keijo, Viiri IR - Keijo V FIR - Daniel, Agardh IR - Daniel A FIR - Andren, Aronsson Carin IR - Andren AC FIR - Markus, Lundgren IR - Markus L FIR - Iida, Makela IR - Iida M FIR - Martin, Romantschuk IR - Martin R FIR - Laura, Soininen IR - Laura S FIR - Nicolai A, Lund-Blix IR - Nicolai A LB FIR - Maria, Magnus IR - Maria M FIR - Aino-Kaisa, Rantala IR - Aino-Kaisa R FIR - Lars, Stene IR - Lars S FIR - Ketil, Stordal IR - Ketil S FIR - German, Tapia IR - German T FIR - Laura, Elo IR - Laura E FIR - Sini, Junttila IR - Sini J FIR - Riitta, Lahesmaa IR - Riitta L FIR - Johanna, Lempainen IR - Johanna L FIR - Robert, Moulder IR - Robert M FIR - Omid, Rasool IR - Omid R FIR - Tomi, Suomi IR - Tomi S FIR - Jorma, Toppari IR - Jorma T FIR - Ubaid, Ullah IR - Ubaid U FIR - Riitta, Veijola IR - Riitta V FIR - Aleksandr, Peet IR - Aleksandr P FIR - Kart, Simre IR - Kart S FIR - Vallo, Tillmann IR - Vallo T FIR - Elena, Bargagli IR - Elena B FIR - Francesco, Dotta IR - Francesco D FIR - Laura, Nigi IR - Laura N FIR - Guido, Sebastiani IR - Guido S FIR - Leena, Hakola IR - Leena H FIR - Hannu, Kiviranta IR - Hannu K FIR - Panu, Rantakokko IR - Panu R FIR - Suvi M, Virtanen IR - Suvi M V FIR - Ondrej, Cinek IR - Ondrej C FIR - Eva, Fronkova IR - Eva F FIR - Jaroslav, Havlik IR - Jaroslav H FIR - Matthieu, Molinier IR - Matthieu M FIR - Juha, Pajula IR - Juha P FIR - Eija, Parmes IR - Eija P FIR - Juha, Parkka IR - Juha P FIR - Petri, Saviranta IR - Petri S FIR - Peter, Ylen IR - Peter Y FIR - Alar, Aints IR - Alar A FIR - Anu, Barenson IR - Anu B FIR - Anne, Kirss IR - Anne K FIR - Ivo, Laidmae IR - Ivo L FIR - Astrid, Oras IR - Astrid O FIR - Aili, Tagoma IR - Aili T FIR - Raivo, Uibo IR - Raivo U FIR - Tamara, Vorobjova IR - Tamara V FIR - Loic, Burr IR - Loic B FIR - Stefano, Cattaneo IR - Stefano C FIR - Hui, Chai-Gao IR - Hui CG FIR - Peter, Cristofollini IR - Peter C FIR - Silvia, Generelli IR - Silvia G FIR - Samantha, Paoletti IR - Samantha P FIR - Edith, Ruth IR - Edith R FIR - Gabriele, Berg IR - Gabriele B FIR - Wisnu, Wicaksono IR - Wisnu W FIR - Joseph, Petrosino IR - Joseph P FIR - Rainer, Thiel IR - Rainer T FIR - Schmidtmann, Daniel IR - Schmidtmann D FIR - Rosanna, Salo IR - Rosanna S FIR - Lauri, Hame IR - Lauri H FIR - Alexander, Berler IR - Alexander B FIR - Korina, Papadopoulou IR - Korina P FIR - Hans, Bisgaard IR - Hans B FIR - Klaus, Bonnelykke IR - Klaus B FIR - Sarah, Brandt IR - Sarah B FIR - Astrid, Sevelsted IR - Astrid S FIR - Jakob, Stokholm IR - Jakob S FIR - Jonathan, Thorsen IR - Jonathan T FIR - Mikael, Knip IR - Mikael K FIR - Aki, Sinkkonen IR - Aki S FIR - Marja, Roslund IR - Marja R EDAT- 2024/06/21 00:42 MHDA- 2024/06/21 00:43 CRDT- 2024/06/20 20:57 PHST- 2024/02/20 00:00 [received] PHST- 2024/04/15 00:00 [revised] PHST- 2024/05/08 00:00 [accepted] PHST- 2024/06/21 00:43 [medline] PHST- 2024/06/21 00:42 [pubmed] PHST- 2024/06/20 20:57 [entrez] AID - S2405-4577(24)00116-5 [pii] AID - 10.1016/j.clnesp.2024.05.001 [doi] PST - ppublish SO - Clin Nutr ESPEN. 2024 Aug;62:22-27. doi: 10.1016/j.clnesp.2024.05.001. Epub 2024 May 11. PMID- 38900805 OWN - NLM STAT- MEDLINE DCOM- 20240620 LR - 20260805 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 6 DP - 2024 TI - Psychometrics validation of the Chinese version of social support for exercise scale among adolescents in China. PG - e0299497 LID - 10.1371/journal.pone.0299497 [doi] LID - e0299497 AB - Physical activity (PA) is widely recognized as crucial for human health, yet the low level of PA in adolescents continues to raise major concerns. This study aims to validate the Chinese version of the Social Support Scale for Exercise (SE) and establish its reliability among Chinese adolescents. A cross-sectional study was conducted on two primary and two secondary schools in central China. Students were recruited using a random cluster sampling method, and written informed consent was provided after they were briefed on the purpose of the study. The standard forward-backward translation was applied to translate the English version of the SE into Chinese. The Social Support Scale used in this study consists of two factors: family support and friend support. Data were analyzed using Mplus 8 for the CFA, composite reliability (CR), average variance extracted (AVE), and intra-class correlation coefficients (ICC) were calculated. A total of 1422 students (boys = 838, girls = 604) with a mean age of 11 years (SD = 1.6) participated in the study. The measurement model of the translated social support scale fit the data well: CFI = .935; TLI = .929; SRMR = .038; RMSEA = .053, with a 90% confidence interval of (.051, .056; RMSEA p < .001). The composite reliability values of .935 for family support and .948 for friend support were acceptable. The intra-class correlation coefficients (ICC) based on test-retest were .928 for family support, and .904 for friend support. Hence, the Chinese version of the SE was valid and reliable, its implementation will provide researchers with a valuable tool to comprehensively assess Chinese adolescents' exercise-related social support and help develop targeted and effective interventions to improve their physical activity levels. CI - Copyright: (c) 2024 Yao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Yao, Liying AU - Yao L AD - School of Physical Education, Shangrao Normal University, Jiangxi, Shangrao, China. AD - Exercise and Sports Science Programme, School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. FAU - Zhou, Ke AU - Zhou K AD - Sports Reform and Development Research Center of Henan University, School of Physical Education, Henan University, Henan, China. FAU - Zhou, Yanli AU - Zhou Y AD - Sports Reform and Development Research Center of Henan University, School of Physical Education, Henan University, Henan, China. FAU - Kueh, Yee Cheng AU - Kueh YC AD - Biostatistics and Research Methodology Unit, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. FAU - Xu, Tingyu AU - Xu T AD - College of Physical Education and Health, Nanchang Institute of Science and Technology, Jiangxi, Nanchang, China. FAU - Pan, Mingzhu AU - Pan M AD - School of Physical Education, Shangrao Normal University, Jiangxi, Shangrao, China. AD - Exercise and Sports Science Programme, School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. FAU - Majeed, Anwar P P Abdul AU - Majeed APPA AD - School of Robotics, XJTLU Entrepreneur College (Taicang), Xi'an Jiaotong-Liverpool University, Suzhou, China. FAU - Liu, Zhongbiao AU - Liu Z AD - School of Physical Education & Sports Science, South China Normal University, Guangzhou, China. FAU - Kuan, Garry AU - Kuan G AUID- ORCID: 0000-0003-1103-3871 AD - Exercise and Sports Science Programme, School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. AD - Department of Life Sciences, Brunel University, London, United Kingdom. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20240620 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Social Support MH - Male MH - Female MH - China MH - *Exercise/psychology MH - Adolescent MH - *Psychometrics/methods MH - Cross-Sectional Studies MH - Child MH - Reproducibility of Results MH - Surveys and Questionnaires MH - Students/psychology PMC - PMC11189212 COIS- The authors have declared that no competing interests exist. EDAT- 2024/06/20 18:43 MHDA- 2024/06/20 18:44 PMCR- 2024/06/20 CRDT- 2024/06/20 13:43 PHST- 2022/12/23 00:00 [received] PHST- 2024/02/11 00:00 [accepted] PHST- 2024/06/20 18:44 [medline] PHST- 2024/06/20 18:43 [pubmed] PHST- 2024/06/20 13:43 [entrez] PHST- 2024/06/20 00:00 [pmc-release] AID - PONE-D-22-32442 [pii] AID - 10.1371/journal.pone.0299497 [doi] PST - epublish SO - PLoS One. 2024 Jun 20;19(6):e0299497. doi: 10.1371/journal.pone.0299497. eCollection 2024. PMID- 38898737 OWN - NLM STAT- MEDLINE DCOM- 20240620 LR - 20250814 IS - 1557-0657 (Electronic) IS - 1049-8931 (Print) IS - 1049-8931 (Linking) VI - 33 IP - 2 DP - 2024 Jun TI - A database of videos of physical exercise and sedentary behaviours to investigate automatic processes and perceptions related to physical exercise. PG - e2022 LID - 10.1002/mpr.2022 [doi] LID - e2022 AB - OBJECTIVE: The Videos of Physical Exercise and Sedentary Behaviours (VPESB) database is a novel database designed to experimentally investigate neural reactivity to physical exercise. The aim of this database is to provide a variety of dynamic images with a minimum of confounding factors. METHODS: A total of 196 healthy participants were recruited to evaluate 10 clips of sedentary activities and 10 clips of physical exercise. Each activity was performed by a male and female performer, resulting in a total of 40 video clips of 10 s each. RESULTS: The validation procedure confirmed the ability of these videoclips to accurately represent both sedentary and physical activity. In addition, video clips of physical activity were associated with higher effort ratings than sedentary activities (p < 0.01). CONCLUSIONS: The VPESB is a versatile, rapid and easy-to-use tool that can be used to understand emotional and behavioural approaches to physical activity and to better disentangle some clinical conditions in which physical activity plays a central role. CI - (c) 2024 The Author(s). International Journal of Methods in Psychiatric Research published by John Wiley & Sons Ltd. FAU - Cascino, Giammarco AU - Cascino G AUID- ORCID: 0000-0003-0358-8594 AD - Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Salerno, Italy. FAU - Di Lodovico, Laura AU - Di Lodovico L AD - Clinique des Maladies Mentales et de l'Encephale, GHU Paris Psychiatrie et Neurosciences, Hopital Sainte-Anne, Paris, France. AD - Universite Bordeaux, INSERM, Neurocentre Magendie, U1215, Bordeaux, France. AD - Universite Paris Cite, INSERM, Institut de Psychiatrie et Neuroscience de Paris (IPNP), U1266, Paris, France. FAU - Ceres, Rossella AU - Ceres R AD - Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Salerno, Italy. AD - Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy. FAU - Monteleone, Alessio Maria AU - Monteleone AM AD - Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy. FAU - Gorwood, Philip AU - Gorwood P AD - Clinique des Maladies Mentales et de l'Encephale, GHU Paris Psychiatrie et Neurosciences, Hopital Sainte-Anne, Paris, France. AD - Universite Paris Cite, INSERM, Institut de Psychiatrie et Neuroscience de Paris (IPNP), U1266, Paris, France. FAU - Monteleone, Palmiero AU - Monteleone P AD - Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Salerno, Italy. LA - eng PT - Journal Article PL - United States TA - Int J Methods Psychiatr Res JT - International journal of methods in psychiatric research JID - 9111433 SB - IM MH - Humans MH - Male MH - Female MH - *Sedentary Behavior MH - *Exercise/physiology MH - Adult MH - Young Adult MH - *Databases, Factual MH - Video Recording MH - Adolescent PMC - PMC11187402 OTO - NOTNLM OT - database OT - physical exercise OT - sedentary behaviour COIS- The authors have no competing interests to declare that are relevant to the content of this article. EDAT- 2024/06/20 06:42 MHDA- 2024/06/20 06:43 PMCR- 2024/06/19 CRDT- 2024/06/20 02:43 PHST- 2024/04/16 00:00 [revised] PHST- 2024/03/12 00:00 [received] PHST- 2024/05/11 00:00 [accepted] PHST- 2024/06/20 06:43 [medline] PHST- 2024/06/20 06:42 [pubmed] PHST- 2024/06/20 02:43 [entrez] PHST- 2024/06/19 00:00 [pmc-release] AID - MPR2022 [pii] AID - 10.1002/mpr.2022 [doi] PST - ppublish SO - Int J Methods Psychiatr Res. 2024 Jun;33(2):e2022. doi: 10.1002/mpr.2022. PMID- 38898432 OWN - NLM STAT- MEDLINE DCOM- 20240620 LR - 20250128 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 Jun 19 TI - Modifiable factors influencing attention performance in healthy children: insights from a comprehensive school nutrition study. PG - 1629 LID - 10.1186/s12889-024-19059-8 [doi] LID - 1629 AB - BACKGROUND: There is inconclusive evidence for the effects of various leisure activities on attention performance in children. The literature reports inconsistent associations between activities such as physical activities or media use. To date, no study has thoroughly examined the various factors influencing attentional performance in a larger cohort of healthy children. This study aims to close this research gap. METHODS: From 2018 to 2019, the Leipzig School Nutrition Study collected data from 1215 children and their families. The children report their dietary behavior (using CoCu- Questionnaire), especially their participation in school lunch and their breakfast habits, through a paper questionnaire. Furthermore, attention performance was assessed using a validated test (FAIR-2) at school. Data on physical activity, media consumption, family eating habits and socio-economic status (SES) were collected from parents using questionnaires. Associations between attention and influencing factors were estimated using hierarchical linear regression. Analyses were adjusted for age, SES, and school type. RESULTS: Attending upper secondary schools (ss(adj)= 23.6, p < 0.001) and having a higher SES (ss= 1.28, p < 0.001) was associated with higher attention performance. Children doing leisure-time sports (ss(adj)= 4.18, p = 0.046) or reading books for at least one hour/weekday showed better attention performance (ss(adj)= 3.8, p = 0.040). Attention performance was also better in children having no electronic devices in the bedroom (ss(adj)= 13.0, p = 0.005) and in children whose parents limited their children's Internet access (ss(adj)= 5.2, p = 0.012). We did not find any association between nutritional habits and attention performance. CONCLUSIONS: We found that fostering modifiable habits such as reading and physical activity could enhance attention performance. These findings have substantial implications for the development of prevention and intervention programs that aim to improve attention in schoolchildren. It is important to note, however, that social status as a hardly modifiable factor also impacts attention performance. Therefore, interventions should address personal habits in a systemic approach considering the child's social status. TRIAL REGISTRATION: The study is retrospectively registered with the German Clinical Trials Register (DRKS00017317, registration: 05-29-2019). CI - (c) 2024. The Author(s). FAU - Ober, Peggy AU - Ober P AD - LIFE Child - Leipzig Research Center for Civilization Diseases, Hospital for Children and Adolescents, Medical Faculty, Leipzig University, 04103, Leipzig, Germany. Peggy.Ober@medizin.uni-leipzig.de. AD - Integrated Research and Treatment Center (IFB)Adiposity Diseases, Medical Faculty, Leipzig University, 04103, Leipzig, Germany. Peggy.Ober@medizin.uni-leipzig.de. FAU - Poulain, Tanja AU - Poulain T AD - LIFE Child - Leipzig Research Center for Civilization Diseases, Hospital for Children and Adolescents, Medical Faculty, Leipzig University, 04103, Leipzig, Germany. AD - Center for Pediatric Research (CPL), Hospital for Children and Adolescents, Medical Faculty, Leipzig University, 04103, Leipzig, Germany. FAU - Meigen, Christof AU - Meigen C AD - LIFE Child - Leipzig Research Center for Civilization Diseases, Hospital for Children and Adolescents, Medical Faculty, Leipzig University, 04103, Leipzig, Germany. AD - Center for Pediatric Research (CPL), Hospital for Children and Adolescents, Medical Faculty, Leipzig University, 04103, Leipzig, Germany. FAU - Spielau, Ulrike AU - Spielau U AD - Center for Pediatric Research (CPL), Hospital for Children and Adolescents, Medical Faculty, Leipzig University, 04103, Leipzig, Germany. AD - Integrated Research and Treatment Center (IFB)Adiposity Diseases, Medical Faculty, Leipzig University, 04103, Leipzig, Germany. FAU - Sobek, Carolin AU - Sobek C AD - LIFE Child - Leipzig Research Center for Civilization Diseases, Hospital for Children and Adolescents, Medical Faculty, Leipzig University, 04103, Leipzig, Germany. AD - Center for Pediatric Research (CPL), Hospital for Children and Adolescents, Medical Faculty, Leipzig University, 04103, Leipzig, Germany. FAU - Kiess, Wieland AU - Kiess W AD - LIFE Child - Leipzig Research Center for Civilization Diseases, Hospital for Children and Adolescents, Medical Faculty, Leipzig University, 04103, Leipzig, Germany. AD - Center for Pediatric Research (CPL), Hospital for Children and Adolescents, Medical Faculty, Leipzig University, 04103, Leipzig, Germany. FAU - Igel, Ulrike AU - Igel U AD - LIFE Child - Leipzig Research Center for Civilization Diseases, Hospital for Children and Adolescents, Medical Faculty, Leipzig University, 04103, Leipzig, Germany. AD - Center for Pediatric Research (CPL), Hospital for Children and Adolescents, Medical Faculty, Leipzig University, 04103, Leipzig, Germany. AD - Department of Applied Social Science, University of Applied Sciences Erfurt, 99085, Erfurt, Germany. FAU - Lipek, Tobias AU - Lipek T AD - Center for Pediatric Research (CPL), Hospital for Children and Adolescents, Medical Faculty, Leipzig University, 04103, Leipzig, Germany. AD - Integrated Research and Treatment Center (IFB)Adiposity Diseases, Medical Faculty, Leipzig University, 04103, Leipzig, Germany. FAU - Vogel, Mandy AU - Vogel M AD - LIFE Child - Leipzig Research Center for Civilization Diseases, Hospital for Children and Adolescents, Medical Faculty, Leipzig University, 04103, Leipzig, Germany. AD - Center for Pediatric Research (CPL), Hospital for Children and Adolescents, Medical Faculty, Leipzig University, 04103, Leipzig, Germany. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240619 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - *Attention MH - *Schools MH - Feeding Behavior/psychology MH - Surveys and Questionnaires MH - Exercise/psychology MH - Germany MH - Leisure Activities/psychology MH - Adolescent PMC - PMC11186167 OTO - NOTNLM OT - Academic performance OT - Attention OT - Breakfast OT - Media consumption OT - School OT - Sport COIS- The authors declare that they have no competing interests. EDAT- 2024/06/20 00:42 MHDA- 2024/06/20 06:41 PMCR- 2024/06/19 CRDT- 2024/06/19 23:35 PHST- 2023/12/18 00:00 [received] PHST- 2024/06/05 00:00 [accepted] PHST- 2024/06/20 06:41 [medline] PHST- 2024/06/20 00:42 [pubmed] PHST- 2024/06/19 23:35 [entrez] PHST- 2024/06/19 00:00 [pmc-release] AID - 10.1186/s12889-024-19059-8 [pii] AID - 19059 [pii] AID - 10.1186/s12889-024-19059-8 [doi] PST - epublish SO - BMC Public Health. 2024 Jun 19;24(1):1629. doi: 10.1186/s12889-024-19059-8. PMID- 38897191 OWN - NLM STAT- MEDLINE DCOM- 20241202 LR - 20241202 IS - 1423-0399 (Electronic) IS - 0042-1138 (Linking) VI - 108 IP - 6 DP - 2024 TI - Predicting Acupuncture Efficacy in Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Study on Model Development and Result Visualization. PG - 500-507 LID - 10.1159/000539856 [doi] AB - INTRODUCTION: Acupuncture is one of primary treatment options for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), but its efficacy varies among patients. This study aimed to develop and validate a nomogram for predicting the efficacy of acupuncture in CP/CPPS. METHODS: This study enrolled 220 patients with CP/CPPS who received acupuncture. Patients were divided into a responder group and nonresponder group based on the reduction in the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). Potential variables were selected using the least absolute shrinkage and selection operator regression, and a nomogram was established using the multivariable logistic regression model. The performance of the nomogram was assessed by the receiver operating characteristic curves and calibration curves. RESULTS: Two Hundred Twenty men were randomly assigned to the training cohort (n = 154) and the internal test cohort (n = 66). The developed nomogram included age, current drinking status, sedentary lifestyle, habit of staying up late, expectations for acupuncture, comorbidities, NIH-CPSI pain subscale and total scores. The area under the curve of the prediction model was 0.777 (95% CI: 0.702-0.851) in the training cohort, 0.752 (95% CI: 0.616-0.888) in the internal test cohort, demonstrating satisfactory discriminative ability as indicated by the calibration curve. CONCLUSIONS: The nomogram accurately identified CP/CPPS patients who would benefit from acupuncture. Factors such as youth, abstention from alcohol, avoiding sedentary habits and staying up late, having high expectations for acupuncture, being free from comorbidities, and baseline high scores on both the NIH-CPSI pain subscale and total scores may positively affect the efficacy of acupuncture. Further validation of our findings requires multicenter and large-sample prospective studies. CI - (c) 2024 S. Karger AG, Basel. FAU - Zhu, Lili AU - Zhu L AD - Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. FAU - Liu, Sixing AU - Liu S AD - School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China. FAU - Fang, Jiufei AU - Fang J AD - Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. FAU - Gao, Shuai AU - Gao S AD - Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. FAU - Sun, Yuanjie AU - Sun Y AD - Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. FAU - Liu, Zhishun AU - Liu Z AD - Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20240619 PL - Switzerland TA - Urol Int JT - Urologia internationalis JID - 0417373 SB - IM MH - Humans MH - Male MH - *Prostatitis/therapy/diagnosis MH - Adult MH - *Acupuncture Therapy MH - *Nomograms MH - Treatment Outcome MH - Middle Aged MH - Pelvic Pain/therapy/diagnosis MH - Young Adult MH - Chronic Pain/therapy OTO - NOTNLM OT - Acupuncture efficacy OT - Chronic prostatitis/chronic pelvic pain syndrome OT - Least absolute shrinkage and selection operator regression OT - Nomogram OT - Prediction model EDAT- 2024/06/20 00:42 MHDA- 2024/12/03 00:23 CRDT- 2024/06/19 18:23 PHST- 2024/03/03 00:00 [received] PHST- 2024/06/08 00:00 [accepted] PHST- 2024/12/03 00:23 [medline] PHST- 2024/06/20 00:42 [pubmed] PHST- 2024/06/19 18:23 [entrez] AID - 000539856 [pii] AID - 10.1159/000539856 [doi] PST - ppublish SO - Urol Int. 2024;108(6):500-507. doi: 10.1159/000539856. Epub 2024 Jun 19. PMID- 38896274 OWN - NLM STAT- MEDLINE DCOM- 20240813 LR - 20250206 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 183 IP - 9 DP - 2024 Sep TI - BODYFAT: a new calculator to determine the risk of being overweight validated in Spanish children between 11 and 17 years of age. PG - 3885-3895 LID - 10.1007/s00431-024-05596-2 [doi] AB - The assessment of body fat of children in primary care requires consideration of the dynamic changes in height, weight, lean mass, and fat mass during childhood growth. To achieve this, we aim to develop a predictive equation based on anthropometric values, with optimal diagnostic utility. This is a cross-sectional observational study, involving schoolgoers aged 11-17 years in the Vigo metropolitan area. Out of 10,747 individuals, 577 were randomly recruited. VARIABLES: age, sex, ethnicity/country of origin, weight, height, 8 skinfolds, 3 diameters, 7 perimeters, and 85% percentile of body fat mass as the gold standard. Generalized additive regression was selected by cross-validation and compared using receiver operating characteristic curves (ROC curves). Sensitivity, specificity, positive and negative predictive values, true positive and true negative values, false positive and false negative values, accuracy, and positive and negative likelihood ratios were calculated. Two models were identified. The optimal model includes sex, weight, height, leg perimeter, and arm perimeter, with sensitivity of 0.93 (0.83-1.00), specificity of 0.91 (0.83-0.96), accuracy of 0.91 (0.84-0.96), and area under the curve (AUC) of 0.957 (0.928-0.986). The second model includes sex, age, and body mass index, with sensitivity of 0.93 (0.81-1.00), specificity of 0.90 (0.80-0.97), accuracy of 0.90 (0.82-0.96), and an AUC of 0.944 (0.903-0.984). CONCLUSION: Two predictive models, with the 85th percentile of fat mass as the gold standard, built with basic anthropometric measures, show very high diagnostic utility parameters. Their calculation is facilitated by a complementary online calculator. WHAT IS KNOWN: * In routine clinical practice, mainly in primary care, BMI is used to determine overweight and obesity. This index has its weaknesses in the assessment of children. WHAT IS NEW: * We provide a calculator whose validated algorithm, through the determination of fat mass by impedanciometry, makes it possible to determine the risk of overweight and obesity in the community setting, through anthropometric measurements, providing a new practical, accessible and reliable model that improves the classification of overweight and obesity in children with respect to that obtained by determining BMI. CI - (c) 2024. The Author(s). FAU - Martin-Miguel, Maria Victoria AU - Martin-Miguel MV AD - Vigo Family and Community Medicine and Nursing Teaching Unit, Health Area of Vigo, SERGAS, Vigo, Spain. AD - I-Saude Group, South Galicia Health Research Institute (Instituto de Investigacion Sanitaria Galicia Sur), SERGAS-UVIGO, Vigo, Spain. AD - Research Netwpork in Chronicity, Primary Care and Health Promotion (Red de Investigacion en Cronicidad, Atencion Primaria y Promocion de la Salud/RICAPPS), Vigo, Spain. FAU - Delgado-Martin, Maria Victoria AU - Delgado-Martin MV AUID- ORCID: 0000-0003-2937-9651 AD - Moana Health Center, SERGAS, Vigo Area, Vigo, Spain. marividelgadomartin@gmail.com. AD - I-Saude Group, South Galicia Health Research Institute (Instituto de Investigacion Sanitaria Galicia Sur), SERGAS-UVIGO, Vigo, Spain. marividelgadomartin@gmail.com. AD - Research Netwpork in Chronicity, Primary Care and Health Promotion (Red de Investigacion en Cronicidad, Atencion Primaria y Promocion de la Salud/RICAPPS), Vigo, Spain. marividelgadomartin@gmail.com. FAU - Barreiro-Arceiz, Carolina AU - Barreiro-Arceiz C AD - Baiona Health Center, SERGAS, Vigo Area, Vigo, Spain. FAU - Goicoechea-Castano, Ana AU - Goicoechea-Castano A AD - Sardoma Health Center, SERGAS, Vigo Area, Vigo, Spain. AD - I-Saude Group, South Galicia Health Research Institute (Instituto de Investigacion Sanitaria Galicia Sur), SERGAS-UVIGO, Vigo, Spain. FAU - Rodriguez-Pastoriza, Sara AU - Rodriguez-Pastoriza S AD - I-Saude Group, South Galicia Health Research Institute (Instituto de Investigacion Sanitaria Galicia Sur), SERGAS-UVIGO, Vigo, Spain. FAU - Gonzalez-Formoso, Clara AU - Gonzalez-Formoso C AD - I-Saude Group, South Galicia Health Research Institute (Instituto de Investigacion Sanitaria Galicia Sur), SERGAS-UVIGO, Vigo, Spain. AD - Ponteareas Health Center, SERGAS, Vigo Area, Vigo, Spain. AD - Research Netwpork in Chronicity, Primary Care and Health Promotion (Red de Investigacion en Cronicidad, Atencion Primaria y Promocion de la Salud/RICAPPS), Vigo, Spain. FAU - Fernandez-Perez, Martin AU - Fernandez-Perez M AD - I-Saude Group, South Galicia Health Research Institute (Instituto de Investigacion Sanitaria Galicia Sur), SERGAS-UVIGO, Vigo, Spain. FAU - Garcia-Cendon, Clara AU - Garcia-Cendon C AD - I-Saude Group, South Galicia Health Research Institute (Instituto de Investigacion Sanitaria Galicia Sur), SERGAS-UVIGO, Vigo, Spain. AD - Val Minor Health Center, SERGAS, Vigo Area, Vigo, Spain. FAU - Roca, Javier AU - Roca J AD - Galician Research and Mathematical Technology Center (Centro de Investigacion e Tecnoloxia Matematica de Galicia/CITMAga) & Department of Statistics and Operations Research, University of Vigo, Vigo, Spain. AD - Research Netwpork in Chronicity, Primary Care and Health Promotion (Red de Investigacion en Cronicidad, Atencion Primaria y Promocion de la Salud/RICAPPS), Vigo, Spain. FAU - Claveria, Ana AU - Claveria A AD - I-Saude Group, South Galicia Health Research Institute (Instituto de Investigacion Sanitaria Galicia Sur), SERGAS-UVIGO, Vigo, Spain. AD - Research Netwpork in Chronicity, Primary Care and Health Promotion (Red de Investigacion en Cronicidad, Atencion Primaria y Promocion de la Salud/RICAPPS), Vigo, Spain. LA - eng PT - Journal Article PT - Observational Study PT - Validation Study DEP - 20240619 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Adolescent MH - Child MH - Male MH - Female MH - Cross-Sectional Studies MH - Spain/epidemiology MH - *Pediatric Obesity/diagnosis/epidemiology MH - Body Mass Index MH - ROC Curve MH - Risk Assessment/methods MH - Sensitivity and Specificity MH - Anthropometry/methods PMC - PMC11322224 OTO - NOTNLM OT - Anthropometry OT - Body composition OT - Body fat OT - Body mass index OT - Children and adolescents OT - Obesity OT - Overweight COIS- The authors have no conflicts of interest to declare that are relevant to the content of this article. EDAT- 2024/06/19 12:43 MHDA- 2024/08/13 12:42 PMCR- 2024/06/19 CRDT- 2024/06/19 11:14 PHST- 2024/02/03 00:00 [received] PHST- 2024/05/02 00:00 [accepted] PHST- 2024/04/27 00:00 [revised] PHST- 2024/08/13 12:42 [medline] PHST- 2024/06/19 12:43 [pubmed] PHST- 2024/06/19 11:14 [entrez] PHST- 2024/06/19 00:00 [pmc-release] AID - 10.1007/s00431-024-05596-2 [pii] AID - 5596 [pii] AID - 10.1007/s00431-024-05596-2 [doi] PST - ppublish SO - Eur J Pediatr. 2024 Sep;183(9):3885-3895. doi: 10.1007/s00431-024-05596-2. Epub 2024 Jun 19. PMID- 38894738 OWN - NLM STAT- MEDLINE DCOM- 20240619 LR - 20260618 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 15 DP - 2024 TI - Comparative analysis through propensity score matching in thyroid cancer: unveiling the impact of multiple malignancies. PG - 1366935 LID - 10.3389/fendo.2024.1366935 [doi] LID - 1366935 AB - BACKGROUND: The incidence of thyroid cancer is on the rise worldwide, with childhood exposure to radiation being the sole acknowledged catalyst for its emergence. Nonetheless, numerous other factors that may pose risks are awaiting thorough examination and validation. This retrospective study aims to explore the malignancies linked to thyroid cancer and contrast the survival rates of those afflicted with a solitary tumor versus those with multiple primary neoplasms (MPN). METHODS: This retrospective study examined data from King Hussein Cancer Center (KHCC), Jordan. Among 563 patients diagnosed with thyroid cancer, 30 patients had thyroid malignancy as part of MPN. For a 1:3 propensity score-matched analysis, 90 patients with only a primary thyroid malignancy were also enrolled. RESULTS: Hematologic and breast malignancies were among the most frequent observed cancers alongside thyroid neoplasm. Patients who had MPN were diagnosed at older age, had higher body mass index and presented with higher thyroglobulin antibody levels (p < 0.05 for each). Additionally, MPN patient displayed a stronger family history for cancers (p= 0.002). A median follow-up duration of 135 months unveiled that MPN patients faced a worse 5-year survival compared to their counterparts with a singular neoplasm (87% vs 100% respectively; p < 0.01). However, no distinction emerged in the 5-year event-free survival between these two groups. CONCLUSION: MPN correlates with a significantly altered survival outcome of thyroid cancer patients. The diagnosis of thyroid carcinoma at an older age, accompanied by elevated initial thyroglobulin antibody levels and a notable familial predisposition, may raise concerns about the potential occurrence of synchronous or metachronous tumors. CI - Copyright (c) 2024 Al-Ibraheem, Abdlkadir, Al-Adhami, Lopci, Al-Omari, Al-Masri, Yousef, Al-Hajaj, Mohamad, Singer and Sykiotis. FAU - Al-Ibraheem, Akram AU - Al-Ibraheem A AD - Department of Nuclear Medicine, King Hussein Cancer Center (KHCC), Amman, Jordan. AD - Division of Nuclear Medicine, Department of Radiology and Nuclear Medicine, the University of Jordan, Amman, Jordan. FAU - Abdlkadir, Ahmed Saad AU - Abdlkadir AS AD - Department of Nuclear Medicine, King Hussein Cancer Center (KHCC), Amman, Jordan. FAU - Al-Adhami, Dhuha Ali AU - Al-Adhami DA AD - Department of Nuclear Medicine, King Hussein Cancer Center (KHCC), Amman, Jordan. FAU - Lopci, Egesta AU - Lopci E AD - Nuclear Medicine Unit, IRCCS- Humanitas Clinical and Research Hospital, Rozzano, Milan, Italy. FAU - Al-Omari, Amal AU - Al-Omari A AD - Office of Scientific Affairs and Research (OSAR), King Hussein Cancer Center (KHCC), Amman, Jordan. FAU - Al-Masri, Mahmoud AU - Al-Masri M AD - Department of Surgery, King Hussein Cancer Center (KHCC), Amman, Jordan. FAU - Yousef, Yacoub AU - Yousef Y AD - Department of Surgery, King Hussein Cancer Center (KHCC), Amman, Jordan. FAU - Al-Hajaj, Nabeela AU - Al-Hajaj N AD - Department of Nuclear Medicine, King Hussein Cancer Center (KHCC), Amman, Jordan. FAU - Mohamad, Issa AU - Mohamad I AD - Department of Radiation Oncology, King Hussein Cancer Center (KHCC), Amman, Jordan. FAU - Singer, Susanne AU - Singer S AD - Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Centre Mainz, Mainz, Germany. FAU - Sykiotis, Gerasimos P AU - Sykiotis GP AD - Department of Endocrinology, Diabetology and Metabolism, Vaud University Hospital Center (CHUV), Lausanne, Switzerland. LA - eng PT - Comparative Study PT - Journal Article DEP - 20240604 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - *Thyroid Neoplasms/epidemiology/mortality MH - Female MH - Male MH - Retrospective Studies MH - *Propensity Score MH - Middle Aged MH - Adult MH - *Neoplasms, Multiple Primary/epidemiology MH - Jordan/epidemiology MH - Survival Rate MH - Aged MH - Follow-Up Studies MH - Prognosis PMC - PMC11184125 OTO - NOTNLM OT - multiple primary cancers OT - multiple primary malignancies OT - multiple primary neoplasms OT - prognosis OT - survival analysis OT - thyroid carcinoma COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2024/06/19 06:42 MHDA- 2024/06/19 06:43 PMCR- 2024/01/01 CRDT- 2024/06/19 04:15 PHST- 2024/01/07 00:00 [received] PHST- 2024/05/22 00:00 [accepted] PHST- 2024/06/19 06:43 [medline] PHST- 2024/06/19 06:42 [pubmed] PHST- 2024/06/19 04:15 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2024.1366935 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2024 Jun 4;15:1366935. doi: 10.3389/fendo.2024.1366935. eCollection 2024. PMID- 38892719 OWN - NLM STAT- MEDLINE DCOM- 20240619 LR - 20240620 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 16 IP - 11 DP - 2024 Jun 6 TI - Dietary Intake among Lebanese Adults: Findings from the Updated LEBANese natiONal Food Consumption Survey (LEBANON-FCS). LID - 10.3390/nu16111784 [doi] LID - 1784 AB - BACKGROUND: The rates of obesity, undernutrition, and other non-communicable diseases are on the rise among Lebanese adults. Therefore, it is crucial to evaluate the food consumption habits of this population to understand diet quality, analyze consumption trends, and compare them to healthy diets known to reduce risks of non-communicable diseases. AIM: To evaluate the food consumption patterns, energy intake, as well as macro- and micro-nutrient intake among a nationally representative sample of Lebanese adults aged 18-64 years old. METHODS: A cross-sectional study was carried out from May to September 2022 involving 444 participants from all eight Lebanese governorates. Sociodemographic and medical information was gathered through a questionnaire, food consumption was evaluated using a validated FFQ and 24 h recall, and anthropometric measurements were recorded. RESULTS: There was a notable lack of adherence to three healthy diets (Mediterranean, EAT-Lancet, USDA) among Lebanese adults. Their dietary pattern is characterized by high energy, added sugars, sodium, and saturated fat intake while being low in healthy fats, vitamin A, D, and E. Adult women are falling short of meeting their daily calcium, vitamin D, iron, and vitamin B12 requirements, putting them at increased risk of anemia, osteoporosis, and other health issues. Grains and cereals were the most consumed food groups, and most participants were found to be overweight or obese. CONCLUSIONS: In conclusion, the results highlight the need for public health policies and interventions aimed at encouraging Lebanese adults to make healthier food choices and transition towards diets like the Mediterranean, EAT-Lancet, or USDA diet. These diets have been shown to promote overall health and wellbeing. FAU - Hoteit, Maha AU - Hoteit M AUID- ORCID: 0000-0001-7392-4835 AD - Food Sciences Unit, National Council for Scientific Research-Lebanon (CNRS-L), Beirut P.O. Box 11-8281, Lebanon. AD - Faculty of Public Health, Section 1, Lebanese University, Beirut P.O. Box 6573, Lebanon. FAU - Khattar, Maroun AU - Khattar M AUID- ORCID: 0009-0005-7253-1630 AD - Faculty of Public Health, Section 1, Lebanese University, Beirut P.O. Box 6573, Lebanon. FAU - Malli, Dana AU - Malli D AUID- ORCID: 0009-0000-2330-2421 AD - Faculty of Public Health, Section 1, Lebanese University, Beirut P.O. Box 6573, Lebanon. FAU - Antar, Esraa AU - Antar E AUID- ORCID: 0009-0005-8613-7503 AD - Faculty of Public Health, Section 1, Lebanese University, Beirut P.O. Box 6573, Lebanon. FAU - Al Hassani, Zahraa AU - Al Hassani Z AD - Faculty of Public Health, Section 1, Lebanese University, Beirut P.O. Box 6573, Lebanon. FAU - Abdallah, Maher AU - Abdallah M AD - Faculty of Public Health, Section 1, Lebanese University, Beirut P.O. Box 6573, Lebanon. FAU - Hachem, Dalia AU - Hachem D AD - Faculty of Public Health, Section 1, Lebanese University, Beirut P.O. Box 6573, Lebanon. FAU - Al Manasfi, Elham AU - Al Manasfi E AD - Arab Group for Scientific Research, Beirut 1103, Lebanon. FAU - Chahine, Abdulrahman AU - Chahine A AD - Arab Group for Scientific Research, Beirut 1103, Lebanon. FAU - Tzenios, Nikolaos AU - Tzenios N AUID- ORCID: 0000-0002-6679-2296 AD - Faculty of Public Health, Charisma University, London EC1V 7QE, UK. FAU - The Adults-Lebanon-Fcs Group AU - The Adults-Lebanon-Fcs Group LA - eng PT - Journal Article DEP - 20240606 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Lebanon/epidemiology MH - Adult MH - Female MH - Male MH - Middle Aged MH - Young Adult MH - Cross-Sectional Studies MH - Adolescent MH - *Feeding Behavior MH - Energy Intake MH - Diet/statistics & numerical data MH - Diet, Healthy/statistics & numerical data MH - Diet Surveys MH - Eating MH - Nutrition Surveys PMC - PMC11174657 OTO - NOTNLM OT - adult OT - food consumption OT - food groups OT - healthy diets OT - macronutrients OT - micronutrients COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/06/19 06:42 MHDA- 2024/06/19 06:43 PMCR- 2024/06/06 CRDT- 2024/06/19 01:12 PHST- 2024/05/21 00:00 [received] PHST- 2024/05/30 00:00 [revised] PHST- 2024/05/30 00:00 [accepted] PHST- 2024/06/19 06:43 [medline] PHST- 2024/06/19 06:42 [pubmed] PHST- 2024/06/19 01:12 [entrez] PHST- 2024/06/06 00:00 [pmc-release] AID - nu16111784 [pii] AID - nutrients-16-01784 [pii] AID - 10.3390/nu16111784 [doi] PST - epublish SO - Nutrients. 2024 Jun 6;16(11):1784. doi: 10.3390/nu16111784. PMID- 38890036 OWN - NLM STAT- MEDLINE DCOM- 20240703 LR - 20240722 IS - 1938-3207 (Electronic) IS - 0002-9165 (Linking) VI - 120 IP - 1 DP - 2024 Jul TI - Equations to estimate human milk intake in infants aged 7 to 10 months: prediction models from a cross-sectional study. PG - 102-110 LID - S0002-9165(24)00399-X [pii] LID - 10.1016/j.ajcnut.2024.04.009 [doi] AB - BACKGROUND: Obtaining valid estimates of nutrient intake in infants is currently limited by the difficulties of accurately measuring human milk intake. Current methods are either unsuitable for large-scale studies (i.e., the gold standard dose-to-mother stable isotope technique) or use set amounts, regardless of known variability in individual intake. OBJECTIVES: This cross-sectional study aimed to develop equations to predict human milk intake using simple measures and to carry out external validation of existing methods against the gold standard technique. METHODS: Data on human milk intake were obtained using the dose-to-mother stable isotope technique in 157 infants aged 7-10 mo and their mothers. Predictive equations were developed using questionnaire and anthropometric data (Model 1) and additional dietary data (Model 2) using lasso regression. Bland-Altman plots and intraclass correlation coefficients (ICC) also assessed the validity of existing methods (FITS and ALSPAC studies). RESULTS: The strongest univariate predictors of human milk intake in infants of 8.3 mo on average (46% female) were infant age, infant body mass index (BMI), number of breastfeeds a day, infant formula consumption, and energy from complementary food intake. Mean [95% confidence interval (CI)] differences in predicted versus measured human milk intake [mean (SD): 762 (257) mL/day] were 0.0 mL/day (-26, 26) for Model 1 (ICC 0.74) and 0.5 mL/day (-21, 22) for Model 2 (ICC 0.83). Corresponding differences were -197 mL/day (-233, -161; ICC 0.32) and -175 mL/day (-216, -134; ICC 0.41) for the methods used by FITS and ALSPAC, respectively. CONCLUSIONS: The Human Milk Intake Level Calculation provides substantial improvements on existing methods to estimate human milk intake in infants aged 7-10 mo, while utilizing data commonly collected in nutrition surveys. Although further validation in an external sample is recommended, these equations can be used to estimate human milk intake at this age with some confidence. This clinical trial was registered at http://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=379436) as ACTRN12620000459921. CI - Copyright (c) 2024 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Haszard, Jillian J AU - Haszard JJ AD - Biostatistics Center, University of Otago, Dunedin, New Zealand. FAU - Heath, Anne-Louise M AU - Heath AM AD - Department of Human Nutrition, University of Otago, Dunedin, New Zealand. FAU - Taylor, Rachael W AU - Taylor RW AD - Department of Medicine, University of Otago, Dunedin, New Zealand. FAU - Bruckner, Bailey AU - Bruckner B AD - Department of Human Nutrition, University of Otago, Dunedin, New Zealand. FAU - Katiforis, Ioanna AU - Katiforis I AD - Department of Human Nutrition, University of Otago, Dunedin, New Zealand. FAU - McLean, Neve H AU - McLean NH AD - Department of Human Nutrition, University of Otago, Dunedin, New Zealand. FAU - Cox, Alice M AU - Cox AM AD - Department of Medicine, University of Otago, Dunedin, New Zealand. FAU - Brown, Kimberley J AU - Brown KJ AD - School of Sport, Exercise and Nutrition, Massey University, Auckland, New Zealand. FAU - Casale, Maria AU - Casale M AD - School of Sport, Exercise and Nutrition, Massey University, Auckland, New Zealand. FAU - Jupiterwala, Rosario AU - Jupiterwala R AD - School of Sport, Exercise and Nutrition, Massey University, Auckland, New Zealand. FAU - Diana, Aly AU - Diana A AD - Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia. FAU - Beck, Kathryn L AU - Beck KL AD - School of Sport, Exercise and Nutrition, Massey University, Auckland, New Zealand. FAU - Conlon, Cathryn A AU - Conlon CA AD - School of Sport, Exercise and Nutrition, Massey University, Auckland, New Zealand. FAU - von Hurst, Pamela R AU - von Hurst PR AD - School of Sport, Exercise and Nutrition, Massey University, Auckland, New Zealand. FAU - Daniels, Lisa AU - Daniels L AD - Department of Medicine, University of Otago, Dunedin, New Zealand. Electronic address: lisa.daniels@otago.ac.nz. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240614 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM CIN - Am J Clin Nutr. 2024 Jul;120(1):5-6. doi: 10.1016/j.ajcnut.2024.05.008. PMID: 38960578 MH - Humans MH - *Milk, Human MH - Cross-Sectional Studies MH - Infant MH - Female MH - Male MH - *Infant Nutritional Physiological Phenomena MH - Breast Feeding MH - Infant Formula MH - Diet MH - Energy Intake MH - Body Mass Index OTO - NOTNLM OT - breast milk intake OT - human milk intake OT - infant OT - lactation OT - prediction equations OT - stable isotope COIS- Conflict of interest The authors declare no competing interests. EDAT- 2024/06/19 00:43 MHDA- 2024/07/04 01:19 CRDT- 2024/06/18 21:58 PHST- 2023/12/14 00:00 [received] PHST- 2024/04/10 00:00 [revised] PHST- 2024/04/15 00:00 [accepted] PHST- 2024/07/04 01:19 [medline] PHST- 2024/06/19 00:43 [pubmed] PHST- 2024/06/18 21:58 [entrez] AID - S0002-9165(24)00399-X [pii] AID - 10.1016/j.ajcnut.2024.04.009 [doi] PST - ppublish SO - Am J Clin Nutr. 2024 Jul;120(1):102-110. doi: 10.1016/j.ajcnut.2024.04.009. Epub 2024 Jun 14. PMID- 38888595 OWN - NLM STAT- MEDLINE DCOM- 20240729 LR - 20240731 IS - 1533-4287 (Electronic) IS - 1064-8011 (Linking) VI - 38 IP - 8 DP - 2024 Aug 1 TI - 4-6 Repetition Maximum (RM) and 1-RM Prediction in Free-Weight Bench Press and Smith Machine Squat Based on Body Mass in Male Athletes. PG - 1366-1371 LID - 10.1519/JSC.0000000000004803 [doi] AB - Dhahbi, W, Padulo, J, Russo, L, Racil, G, Ltifi, M-A, Picerno, P, Iuliano, E, and Migliaccio, GM. Four- to 6-repetition maximum and 1-repetition maximum estimation in free-weight bench press and smith machine squat based on body mass in male athletes. J Strength Cond Res 38(8): 1366-1371, 2024-This study aimed to explore the feasibility and face validity of predicting maximum strength 1 repetition maximum (1-RM) and 4-6 RM in athletes across different sports specialties, based on the relationship between muscle strength and BM. One hundred fifteen male athletes, aged 23.63 +/- 6.77 years and participating in diverse sports specialties, were included in this study. Muscle strength was assessed using the 4-6 RM and 1-RM tests in free-weight bench press (BP) and Smith machine squat (SQ) exercises, whereas BM was measured using a portable digital scale. A linear regression equation based on muscle strength and BM was performed. The 4-6 RM and 1-RM scores showed excellent intersession relative reliability (intraclass correlation coefficient (2,1) : 0.946-0.989) and absolute reliability (CV: 3.4-4.7%) in both BP and SQ exercises. In addition, the magnitude of the relationship and the coefficients used to estimate the 4-6 RM and 1RM, based on BM, differed among the subjects when they are grouped according to their sports specialties ( R2 ranged from non-significant to 0.998). Overall, the 4-6 RM test showed a stronger correlation with BM ( R : 0.655 for SQ and R : 0.683 for BP) than the 1RM ( R : 0.552 for SQ and R : 0.629 for BP), and the general (i.e., not sport-specific) 4 to 6-RM prediction equations should be preferred over sport-specific ones because they are statistically more robust due to the larger sample size. In conclusion, the 4-6 RM can be predicted from BM with high reliability, a moderate association, and a prediction error that, when considering the 4-6 RM as a starting point for estimating of the 1RM, can be considered entirely acceptable in practical settings. CI - Copyright (c) 2024 National Strength and Conditioning Association. FAU - Dhahbi, Wissem AU - Dhahbi W AD - Research Unit "Sport Sciences, Health and Movement", Higher Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia. AD - Training Department, Qatar Police College, Doha, Qatar. FAU - Padulo, Johnny AU - Padulo J AD - Department of Biomedical Sciences for Health, Universita degli Studi di Milano, Milan, Italy. FAU - Russo, Luca AU - Russo L AD - Department of Human Sciences, Universita Telematica degli Studi IUL, Florence, Italy. FAU - Racil, Ghazi AU - Racil G AD - Research Unit "Sport Sciences, Health and Movement", Higher Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia. AD - Training Department, Qatar Police College, Doha, Qatar. AD - Department of Biomedical Sciences for Health, Universita degli Studi di Milano, Milan, Italy. AD - Department of Human Sciences, Universita Telematica degli Studi IUL, Florence, Italy. AD - Research Laboratory (LR23JS01): "Sports Performance, Health & Society" Higher Institute of the Sport and Physical Education of Sar Said, University of Manouba, Tunis, Tunisia. AD - Departement of Biomedical Sciences, University of Sassari, Sassari, Italy. AD - Faculty of Psicology, eCampus University, Novedrate, Italy; and. AD - Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Rome Open University, Rome, Italy. FAU - Ltifi, Mohamed-Amine AU - Ltifi MA AD - Research Laboratory (LR23JS01): "Sports Performance, Health & Society" Higher Institute of the Sport and Physical Education of Sar Said, University of Manouba, Tunis, Tunisia. FAU - Picerno, Pietro AU - Picerno P AD - Departement of Biomedical Sciences, University of Sassari, Sassari, Italy. FAU - Iuliano, Enzo AU - Iuliano E AD - Faculty of Psicology, eCampus University, Novedrate, Italy; and. FAU - Migliaccio, Gian Mario AU - Migliaccio GM AUID- ORCID: 0000-0002-7144-7403 AD - Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Rome Open University, Rome, Italy. LA - eng PT - Journal Article DEP - 20240618 PL - United States TA - J Strength Cond Res JT - Journal of strength and conditioning research JID - 9415084 SB - IM MH - Humans MH - Male MH - *Muscle Strength/physiology MH - *Weight Lifting/physiology MH - Young Adult MH - Adult MH - Reproducibility of Results MH - *Athletes MH - Resistance Training/instrumentation/methods MH - Body Mass Index MH - Adolescent EDAT- 2024/06/18 17:42 MHDA- 2024/07/29 12:44 CRDT- 2024/06/18 10:54 PHST- 2024/07/29 12:44 [medline] PHST- 2024/06/18 17:42 [pubmed] PHST- 2024/06/18 10:54 [entrez] AID - 00124278-202408000-00002 [pii] AID - 10.1519/JSC.0000000000004803 [doi] PST - ppublish SO - J Strength Cond Res. 2024 Aug 1;38(8):1366-1371. doi: 10.1519/JSC.0000000000004803. Epub 2024 Jun 18. PMID- 38888562 OWN - NLM STAT- MEDLINE DCOM- 20240917 LR - 20240917 IS - 1827-1928 (Electronic) IS - 0022-4707 (Linking) VI - 64 IP - 10 DP - 2024 Oct TI - A reproducible, self-reported, field-based tool for monitoring ovarian hormone status and body weight variations in female athletes: the Answ'Her questionnaire. PG - 1087-1097 LID - 10.23736/S0022-4707.24.15879-3 [doi] AB - BACKGROUND: Intra-individual factors like ovarian hormone profiles and body weight variations may influence sports practice and performance in female athletes and need to be characterized. The "Answ'Her" questionnaire was designed to develop a relevant and reproducible field-based tool to assess self-reported ovarian hormone status (natural menstrual cycle and hormonal contraceptive use) and body weight variations practices among female athletes. METHODS: French females with a regular sports practice responded (once: N.=210; twice: N.=86; thrice: N.=66) to this 73-item questionnaire reporting their ovarian hormone status, associated symptoms, perceived influence on sports practice, and body weight variations. Reproducibility was evaluated, then a descriptive cross-sectional analysis was conducted on athletes. RESULTS: Reproducibility was verified with 92% of Lin's correlation concordance coefficients above 0.7 and 100% of weighted agreements above 70%. Ultimately 185 female athletes (23.0+/-4.8 years) were included in the cross-sectional analysis. Whether they used hormonal contraceptive (46.5%) or not (53.5%), most of the athletes perceived a negative impact of their ovarian hormone status on sports practice (78.7%) and performance (84.7%). Overall, 77.3% of the athletes had experienced body weight variations that were significantly associated with an interruption of menses (>3 months) and menses irregularity over the last three years. CONCLUSIONS: The Answ'Her questionnaire is a simple and effective reproducible field-based tool for the self-reported characterisation of female athlete ovarian hormone status and body weight variations. It could be used for a unique and simple overview of the athlete situation but also in a longitudinal design to assess the athlete's evolution and/or effectiveness of implanted training strategies. FAU - Bagot, Sarah AU - Bagot S AD - Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), CRNH Auvergne, Clermont Auvergne University, Clermont-Ferrand, France - sarah.bagot@uca.fr. FAU - Pereira, Bruno AU - Pereira B AD - Biostatistics Unit, DRCI, CHU Clermont-Ferrand, Clermont-Ferrand, France. FAU - Lambert, Celine AU - Lambert C AD - Biostatistics Unit, DRCI, CHU Clermont-Ferrand, Clermont-Ferrand, France. FAU - Pelissier, Lena AU - Pelissier L AD - Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), CRNH Auvergne, Clermont Auvergne University, Clermont-Ferrand, France. FAU - Chanseaume, Emilie AU - Chanseaume E AD - Nutrifizz, Clermont-Ferrand, France. FAU - Duclos, Martine AU - Duclos M AD - Department of Sport Medicine and Functional Explorations, CHU Clermont-Ferrand, Clermont-Ferrand, France. FAU - Hackney, Anthony C AU - Hackney AC AD - Department of Exercise and Sport Science, University of North Carolina, Chapel Hill, NC, USA. AD - Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA. FAU - Elliott-Sale, Kirsty J AU - Elliott-Sale KJ AD - Department of Sport and Exercise Sciences, Manchester Metropolitan University Institute of Sport, Manchester, UK. FAU - Thivel, David AU - Thivel D AD - Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), CRNH Auvergne, Clermont Auvergne University, Clermont-Ferrand, France. FAU - Isacco, Laurie AU - Isacco L AD - Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), CRNH Auvergne, Clermont Auvergne University, Clermont-Ferrand, France. LA - eng PT - Journal Article DEP - 20240618 PL - Italy TA - J Sports Med Phys Fitness JT - The Journal of sports medicine and physical fitness JID - 0376337 RN - 0 (Contraceptives, Oral, Hormonal) SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Adult MH - *Body Weight MH - *Self Report MH - Young Adult MH - *Athletes MH - Reproducibility of Results MH - Surveys and Questionnaires MH - Adolescent MH - Menstrual Cycle/physiology MH - Contraceptives, Oral, Hormonal/administration & dosage MH - Athletic Performance/physiology EDAT- 2024/06/18 17:42 MHDA- 2024/09/17 23:42 CRDT- 2024/06/18 10:42 PHST- 2024/09/17 23:42 [medline] PHST- 2024/06/18 17:42 [pubmed] PHST- 2024/06/18 10:42 [entrez] AID - S0022-4707.24.15879-3 [pii] AID - 10.23736/S0022-4707.24.15879-3 [doi] PST - ppublish SO - J Sports Med Phys Fitness. 2024 Oct;64(10):1087-1097. doi: 10.23736/S0022-4707.24.15879-3. Epub 2024 Jun 18. PMID- 38879627 OWN - NLM STAT- MEDLINE DCOM- 20250423 LR - 20261010 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) VI - 96 IP - 7 DP - 2024 Dec TI - Associations between polygenic risk scores for cardiometabolic phenotypes and adolescent depression and body dissatisfaction. PG - 1853-1860 LID - 10.1038/s41390-024-03323-z [doi] AB - BACKGROUND: Adolescents with elevated body mass index (BMI) are at an increased risk for depression and body dissatisfaction. Type 2 diabetes (T2D) is an established risk factor for depression. However, shared genetic risk between cardiometabolic conditions and mental health outcomes remains understudied in youth. METHODS: The current study examined associations between polygenic risk scores (PRS) for BMI and T2D, and symptoms of depression and body dissatisfaction, in a sample of 827 community adolescents (M(age) = 13.63, SD(age) = 1.01; 76% girls). BMI, depressive symptoms, and body dissatisfaction were assessed using validated self-report questionnaires. RESULTS: BMI-PRS was associated with phenotypic BMI (beta = 0.24, p < 0.001) and body dissatisfaction (beta = 0.17, p < 0.001), but not with depressive symptoms. The association between BMI-PRS and body dissatisfaction was significantly mediated by BMI (indirect effect = 0.10, CI [0.07-0.13]). T2D-PRS was not associated with depression or body dissatisfaction. CONCLUSIONS: The results suggest phenotypic BMI may largely explain the association between genetic risk for elevated BMI and body dissatisfaction in adolescents. Further research on age-specific genetic effects is needed, as summary statistics from adult discovery samples may have limited utility in youth. IMPACT: The association between genetic risk for elevated BMI and body dissatisfaction in adolescents may be largely explained by phenotypic BMI, indicating a potential pathway through which genetic predisposition influences body image perception. Furthermore, age-specific genetic research is needed to understand the unique influences on health outcomes during adolescence. By identifying BMI as a potential mediator in the association between genetic risk for elevated BMI and body dissatisfaction, the current findings offer insights that could inform interventions targeting body image concerns and mental health in this population. CI - (c) 2024. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - Ekberg, Krista M AU - Ekberg KM AUID- ORCID: 0000-0003-3174-2130 AD - Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA. krista.ekberg@my.rfums.org. FAU - Michelini, Giorgia AU - Michelini G AD - Department of Biological and Experimental Psychology, Queen Mary University of London, London, UK. FAU - Schneider, Kristin L AU - Schneider KL AD - Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA. FAU - Docherty, Anna R AU - Docherty AR AD - Department of Psychiatry, University of Utah, Salt Lake City, UT, USA. FAU - Shabalin, Andrey A AU - Shabalin AA AD - Department of Psychiatry, University of Utah, Salt Lake City, UT, USA. FAU - Perlman, Greg AU - Perlman G AD - Department of Psychiatry, Stony Brook University, Stony Brook, NY, USA. FAU - Kotov, Roman AU - Kotov R AD - Department of Psychiatry, Stony Brook University, Stony Brook, NY, USA. FAU - Klein, Daniel N AU - Klein DN AD - Department of Psychology, Stony Brook University, Stony Brook, NY, USA. FAU - Waszczuk, Monika A AU - Waszczuk MA AD - Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA. LA - eng PT - Journal Article DEP - 20240615 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM CIN - Pediatr Res. 2024 Dec;96(7):1545-1547. doi: 10.1038/s41390-024-03442-7. PMID: 39103630 MH - Humans MH - Adolescent MH - Female MH - *Depression/genetics MH - Body Mass Index MH - Male MH - *Multifactorial Inheritance MH - Phenotype MH - *Body Dissatisfaction MH - *Diabetes Mellitus, Type 2/genetics/psychology MH - Genetic Predisposition to Disease MH - Risk Factors MH - Body Image MH - Surveys and Questionnaires MH - Cardiometabolic Risk Factors MH - Child MH - Self Report MH - Genetic Risk Score COIS- Competing interests: The authors declare no competing interests. EDAT- 2024/06/16 11:58 MHDA- 2025/01/28 00:21 CRDT- 2024/06/15 23:23 PHST- 2024/03/13 00:00 [received] PHST- 2024/05/27 00:00 [accepted] PHST- 2024/05/22 00:00 [revised] PHST- 2025/01/28 00:21 [medline] PHST- 2024/06/16 11:58 [pubmed] PHST- 2024/06/15 23:23 [entrez] AID - 10.1038/s41390-024-03323-z [pii] AID - 10.1038/s41390-024-03323-z [doi] PST - ppublish SO - Pediatr Res. 2024 Dec;96(7):1853-1860. doi: 10.1038/s41390-024-03323-z. Epub 2024 Jun 15. PMID- 38879445 OWN - NLM STAT- MEDLINE DCOM- 20240820 LR - 20260823 IS - 1465-735X (Electronic) IS - 0146-8693 (Print) IS - 0146-8693 (Linking) VI - 49 IP - 8 DP - 2024 Aug 1 TI - Optimism, pessimism, and physical health among youth: a scoping review. PG - 580-595 LID - 10.1093/jpepsy/jsae045 [doi] AB - OBJECTIVE: High levels of optimism (and low levels of pessimism) are associated with improved physical health in adults. However, relatively less is known about these relations in youth. The present study aimed to review the literature investigating optimism, pessimism, and physical health in children and adolescents from populations with and without health conditions. METHODS: We conducted a scoping review up until February 2024. Studies were included if they sampled youth (average age /=7.8 mmol/L) noninvasively and evaluate diabetic risk based on repeated measurements. METHODS: This study was conducted at KK Women's and Children's Hospital in Singapore, and 500 participants were recruited (mean age 38.73, SD 10.61 years; mean BMI 24.4, SD 5.1 kg/m(2)). The blood glucose levels for most participants were measured before and after consuming 75 g of sugary drinks using both a conventional glucometer (Accu-Chek Performa) and a wrist-worn wearable. The results obtained from the glucometer were used as ground-truth measurements. We performed extensive feature engineering on photoplethysmography (PPG) sensor data and identified features that were sensitive to glucose changes. These selected features were further analyzed using an explainable artificial intelligence approach to understand their contribution to our predictions. RESULTS: Multiple machine learning models were trained and assessed with 10-fold cross-validation, using participant demographic data and critical features extracted from PPG measurements as predictors. A support vector machine with a radial basis function kernel had the best detection performance, with an average accuracy of 84.7%, a sensitivity of 81.05%, a specificity of 88.3%, a precision of 87.51%, a geometric mean of 84.54%, and F score of 84.03%. CONCLUSIONS: Our findings suggest that PPG measurements can be used to identify participants with elevated blood glucose measurements and assist in the screening of participants for diabetes risk. CI - (c)Bohan Shi, Satvinder Singh Dhaliwal, Marcus Soo, Cheri Chan, Jocelin Wong, Natalie W C Lam, Entong Zhou, Vivien Paitimusa, Kum Yin Loke, Joel Chin, Mei Tuan Chua, Kathy Chiew Suan Liaw, Amos W H Lim, Fadil Fatin Insyirah, Shih-Cheng Yen, Arthur Tay, Seng Bin Ang. Originally published in JMIR AI (https://ai.jmir.org), 27.10.2023. FAU - Shi, Bohan AU - Shi B AUID- ORCID: 0000-0003-0338-724X AD - Actxa Pte Ltd, Singapore, Singapore. AD - Activate Interactive Pte Ltd, Singapore, Singapore. FAU - Dhaliwal, Satvinder Singh AU - Dhaliwal SS AUID- ORCID: 0000-0002-4476-1042 AD - Curtin Health Innovation Research Institute, Curtin University, Perth, Australia. AD - Faculty of Health Sciences, Curtin University, Perth, Australia. AD - Duke-NUS Graduate Medical School, National University of Singapore, Singapore, Singapore. FAU - Soo, Marcus AU - Soo M AUID- ORCID: 0009-0001-9438-4281 AD - Actxa Pte Ltd, Singapore, Singapore. FAU - Chan, Cheri AU - Chan C AUID- ORCID: 0009-0000-5895-7858 AD - KK Women's and Children's Hospital, Singapore, Singapore. FAU - Wong, Jocelin AU - Wong J AUID- ORCID: 0009-0007-6632-2458 AD - Actxa Pte Ltd, Singapore, Singapore. FAU - Lam, Natalie W C AU - Lam NWC AUID- ORCID: 0009-0000-4111-8484 AD - Activate Interactive Pte Ltd, Singapore, Singapore. FAU - Zhou, Entong AU - Zhou E AUID- ORCID: 0009-0002-6508-1465 AD - Activate Interactive Pte Ltd, Singapore, Singapore. FAU - Paitimusa, Vivien AU - Paitimusa V AUID- ORCID: 0009-0006-9450-7014 AD - Activate Interactive Pte Ltd, Singapore, Singapore. FAU - Loke, Kum Yin AU - Loke KY AUID- ORCID: 0009-0007-0157-7038 AD - Activate Interactive Pte Ltd, Singapore, Singapore. FAU - Chin, Joel AU - Chin J AUID- ORCID: 0009-0006-1590-0943 AD - Activate Interactive Pte Ltd, Singapore, Singapore. FAU - Chua, Mei Tuan AU - Chua MT AUID- ORCID: 0009-0006-6009-1735 AD - KK Women's and Children's Hospital, Singapore, Singapore. FAU - Liaw, Kathy Chiew Suan AU - Liaw KCS AUID- ORCID: 0009-0001-8128-2411 AD - KK Women's and Children's Hospital, Singapore, Singapore. FAU - Lim, Amos W H AU - Lim AWH AUID- ORCID: 0000-0001-5451-3678 AD - Actxa Pte Ltd, Singapore, Singapore. FAU - Insyirah, Fadil Fatin AU - Insyirah FF AUID- ORCID: 0009-0006-0546-739X AD - KK Women's and Children's Hospital, Singapore, Singapore. FAU - Yen, Shih-Cheng AU - Yen SC AUID- ORCID: 0000-0001-7723-0072 AD - Innovation and Design Programme, Faculty of Engineering, National University of Singapore, Singapore, Singapore. FAU - Tay, Arthur AU - Tay A AUID- ORCID: 0000-0002-3197-2369 AD - Department of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore. FAU - Ang, Seng Bin AU - Ang SB AUID- ORCID: 0000-0003-0883-634X AD - Family Medicine Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore. AD - Menopause Unit, KK Women's and Children's Hospital, Singapore, Singapore. LA - eng PT - Journal Article DEP - 20231027 PL - Canada TA - JMIR AI JT - JMIR AI JID - 9918645789006676 PMC - PMC11041426 OTO - NOTNLM OT - diabetes mellitus OT - explainable artificial intelligence OT - feature engineering OT - machine learning OT - photoplethysmography OT - wearable sensor COIS- Conflicts of Interest: The authors would like to disclose that BS, MS, JW, AWHL, and JC are employed by Actxa Pte Ltd. The authors have an approved plan for managing any potential conflicts arising from employment. SBA and SSD are on the advisory board of Actxa Pte Ltd. All other authors declare that they have no conflicts of interest. EDAT- 2024/06/14 18:42 MHDA- 2024/06/14 18:43 PMCR- 2023/10/27 CRDT- 2024/06/14 16:53 PHST- 2023/04/22 00:00 [received] PHST- 2023/09/28 00:00 [accepted] PHST- 2023/08/31 00:00 [revised] PHST- 2024/06/14 18:43 [medline] PHST- 2024/06/14 18:42 [pubmed] PHST- 2024/06/14 16:53 [entrez] PHST- 2023/10/27 00:00 [pmc-release] AID - v2i1e48340 [pii] AID - 10.2196/48340 [doi] PST - epublish SO - JMIR AI. 2023 Oct 27;2:e48340. doi: 10.2196/48340. PMID- 38873707 OWN - NLM STAT- MEDLINE DCOM- 20241017 LR - 20241017 IS - 1365-2842 (Electronic) IS - 0305-182X (Linking) VI - 51 IP - 10 DP - 2024 Oct TI - The test of masticating and swallowing solids (ToMaSS): An investigation of applicability and clinical utility in children with orofacial myofunctional disorders. PG - 1966-1972 LID - 10.1111/joor.13776 [doi] AB - BACKGROUND: Orofacial myofunctional disorders (OMD) are often associated with limitations of oral ingestion of solid food. The Test of Masticating and Swallowing Solids (ToMaSS) is a simple diagnostic tool to assess and quantify oropharyngeal efficiency while eating a standardised cracker. OBJECTIVES: The objective of this study was to investigate the applicability and clinical utility of the ToMaSS in children with OMD. METHODS: In this case-control study, data were collected from 18 children between 4 and 11 years with confirmed OMD. Inter-rater reliability and age effects on the ToMaSS parameters were investigated and the specific performance profile of the OMD children was identified. RESULTS: Inter-rater reliability was excellent for the ToMaSS parameters 'bites' (ICC = .999), 'masticatory cycles' (ICC = .961), 'time'(ICC>== .999) and good for 'number of swallows' (ICC = .810). 'Masticatory cycles' and 'time' decreased as a function of age with a significant difference in the 'number of masticatory cycles' between the youngest (4-6 years) and oldest (10-14 years) participants (p = .006, Z = -2.739). Deviations from normative data in at least one of the four ToMaSS parameters were found in 90% of the OMD children with 'bites', and 'masticatory cycles' predominantly corresponding to the performances expected in typically-developing children in younger age groups. CONCLUSIONS: The ToMaSS is a reliable diagnostic instrument and clinically useful to detect limited efficiency of oral solid bolus intake and specific impairments in chewing function and duration of food intake in children with OMD. Our data suggest that OMD is associated with delayed development of efficient solid bolus preparation. CI - (c) 2024 The Author(s). Journal of Oral Rehabilitation published by John Wiley & Sons Ltd. FAU - Lorenz, Marlene AU - Lorenz M AD - Praxis fur Logopaedie und Dysphagietherapie, Berlin, Germany. AD - Linguistic Department, Swallowing Research Lab, University of Potsdam, Potsdam, Germany. FAU - Goetze, Danae AU - Goetze D AD - Linguistic Department, Swallowing Research Lab, University of Potsdam, Potsdam, Germany. AD - Ludwig-Maximilians-University, Munich, Germany. FAU - Sargolzaei, Kian AU - Sargolzaei K AD - Dentalzentrum Pankow, Berlin, Germany. FAU - Frank, Ulrike AU - Frank U AUID- ORCID: 0000-0002-0578-8461 AD - Linguistic Department, Swallowing Research Lab, University of Potsdam, Potsdam, Germany. LA - eng GR - University of Potsdam/ PT - Journal Article DEP - 20240614 PL - England TA - J Oral Rehabil JT - Journal of oral rehabilitation JID - 0433604 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - *Mastication/physiology MH - *Deglutition/physiology MH - Case-Control Studies MH - Child, Preschool MH - Reproducibility of Results MH - *Deglutition Disorders/physiopathology/diagnosis OTO - NOTNLM OT - assessment OT - children OT - masticatory function OT - orofacial myofunctional disorders (OMD) OT - swallowing OT - test of masticating and swallowing solids (ToMaSS) EDAT- 2024/06/14 06:43 MHDA- 2024/10/17 23:58 CRDT- 2024/06/14 04:33 PHST- 2023/10/08 00:00 [revised] PHST- 2023/07/27 00:00 [received] PHST- 2024/05/31 00:00 [accepted] PHST- 2024/10/17 23:58 [medline] PHST- 2024/06/14 06:43 [pubmed] PHST- 2024/06/14 04:33 [entrez] AID - 10.1111/joor.13776 [doi] PST - ppublish SO - J Oral Rehabil. 2024 Oct;51(10):1966-1972. doi: 10.1111/joor.13776. Epub 2024 Jun 14. PMID- 38873702 OWN - NLM STAT- MEDLINE DCOM- 20240812 LR - 20240812 IS - 1550-9613 (Electronic) IS - 0278-4297 (Linking) VI - 43 IP - 9 DP - 2024 Sep TI - Unsupervised Learning-Based Measurement of Ultrasonic Axial Transmission Velocity in Neonatal Bone. PG - 1711-1722 LID - 10.1002/jum.16505 [doi] AB - OBJECTIVES: To develop a robust algorithm for estimating ultrasonic axial transmission velocity from neonatal tibial bone, and to investigate the relationships between ultrasound velocity and neonatal anthropometric measurements as well as clinical biochemical markers of skeletal health. METHODS: This study presents an unsupervised learning approach for the automatic detection of first arrival time and estimation of ultrasonic velocity from axial transmission waveforms, which potentially indicates bone quality. The proposed method combines the ReliefF algorithm and fuzzy C-means clustering. It was first validated using an in vitro dataset measured from a Sawbones phantom. It was subsequently applied on in vivo signals collected from 40 infants, comprising 21 males and 19 females. The extracted neonatal ultrasonic velocity was subjected to statistical analysis to explore correlations with the infants' anthropometric features and biochemical indicators. RESULTS: The results of in vivo data analysis revealed significant correlations between the extracted ultrasonic velocity and the neonatal anthropometric measurements and biochemical markers. The velocity of first arrival signals showed good associations with body weight (rho = 0.583, P value <.001), body length (rho = 0.583, P value <.001), and gestational age (rho = 0.557, P value <.001). CONCLUSION: These findings suggest that fuzzy C-means clustering is highly effective in extracting ultrasonic propagating velocity in bone and reliably applicable in in vivo measurement. This work is a preliminary study that holds promise in advancing the development of a standardized ultrasonic tool for assessing neonatal bone health. Such advancements are crucial in the accurate diagnosis of bone growth disorders. CI - (c) 2024 American Institute of Ultrasound in Medicine. FAU - Li, Qing AU - Li Q AD - Department of Biomedical Engineering, Fudan University, Shanghai, China. FAU - Tran, Tho N H T AU - Tran TNHT AUID- ORCID: 0000-0002-1269-1166 AD - Academy for Engineering and Technology, Fudan University, Shanghai, China. FAU - Guo, Jialin AU - Guo J AD - Department of Neonatology, Shanghai First Maternity and Infant Hospital, Shanghai, China. FAU - Li, Boyi AU - Li B AD - Academy for Engineering and Technology, Fudan University, Shanghai, China. FAU - Xu, Kailiang AU - Xu K AD - Department of Biomedical Engineering, Fudan University, Shanghai, China. AD - Yiwu Research Institute, Fudan University, Zhejiang, China. FAU - Le, Lawrence H AU - Le LH AD - Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada. FAU - Ta, Dean AU - Ta D AD - Department of Biomedical Engineering, Fudan University, Shanghai, China. AD - Academy for Engineering and Technology, Fudan University, Shanghai, China. AD - Yiwu Research Institute, Fudan University, Zhejiang, China. LA - eng GR - 12004079/National Natural Science Foundation of China/ GR - 12104096/National Natural Science Foundation of China/ GR - 11827808/National Natural Science Foundation of China/ GR - 2021T140128/China Postdoctoral Science Foundation/ GR - 2021M690709/China Postdoctoral Science Foundation/ PT - Journal Article DEP - 20240614 PL - England TA - J Ultrasound Med JT - Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine JID - 8211547 SB - IM MH - Humans MH - Infant, Newborn MH - *Ultrasonography/methods MH - Female MH - Male MH - *Unsupervised Machine Learning MH - *Tibia/diagnostic imaging/physiology MH - Phantoms, Imaging MH - Algorithms MH - Reproducibility of Results OTO - NOTNLM OT - ReliefF algorithm OT - axial transmission OT - bone quantitative ultrasound OT - fuzzy C-means clustering OT - speed of sound EDAT- 2024/06/14 06:42 MHDA- 2024/08/12 06:43 CRDT- 2024/06/14 04:32 PHST- 2024/04/21 00:00 [revised] PHST- 2024/01/02 00:00 [received] PHST- 2024/05/25 00:00 [accepted] PHST- 2024/08/12 06:43 [medline] PHST- 2024/06/14 06:42 [pubmed] PHST- 2024/06/14 04:32 [entrez] AID - 10.1002/jum.16505 [doi] PST - ppublish SO - J Ultrasound Med. 2024 Sep;43(9):1711-1722. doi: 10.1002/jum.16505. Epub 2024 Jun 14. PMID- 38870325 OWN - NLM STAT- MEDLINE DCOM- 20250423 LR - 20250423 IS - 1945-7197 (Electronic) IS - 0021-972X (Linking) VI - 110 IP - 5 DP - 2025 Apr 22 TI - Prospective Associations of Maternal Cardiometabolic Health With Children Cardiometabolic Health at Ages 3 to 6 Years. PG - 1434-1443 LID - 10.1210/clinem/dgae413 [doi] AB - OBJECTIVE: Maternal cardiometabolic health (MCMH) may have critical effects on offspring lifetime cardiometabolic health (CMH), whereas evidence on the relationship between MCMH during pregnancy and children CMH (CCMH) at ages 3 approximately 6 years remains unknown. METHOD: The study included 1478 mother-child dyads from the Shanghai Maternal-Child Pairs Cohort study. MCMH was examined at a mean of 27.8 (24-36) weeks' gestation based on 8 metrics of the "Life Essential 8" framework involving prepregnancy body mass index, total cholesterol, glucose level, blood pressure, physical activity, sleep, diet quality, and nicotine exposure. CCMH was examined at the age of 3 to 6 based on 5 metrics including body mass index, physical activity, sleep health, diet quality, and nicotine exposure. To validate the robustness of the main analysis, 499 children were selected to reevaluate CCMH by 6 metrics (adding blood pressure) for sensitivity analysis. RESULTS: Among 1478 mother-child dyads, the mean (SD) MCMH during pregnancy and CCMH scores were 67.07 (SD 8.82) and 73.80 (SD 10.75), respectively. After adjusting important confounders, each 10-point increase in (more favorable) MCMH score was significantly associated with a higher CCMH score [beta: .85; 95% confidence interval (CI): .22, 1.47]. Subgroup analysis showed similar results in girls but not in boys. For cardiometabolic risk factors in children, the risk of overweight/obesity and hypertension in children decreased with increased MCMH score [overweight/obesity, relative risks (RRs): .98, 95% CI: .96, .99; hypertension, RRs: .66, 95% CI: .47, .92]. Sensitivity analysis showed similar results. CONCLUSION: Better MCMH in pregnancy was associated with better CCMH at ages 3 approximately 6 years. CI - (c) The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. See the journal About page for additional terms. FAU - Jing, Guangzhuang AU - Jing G AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Fudan University, Shanghai 200032, China. FAU - Ye, Peiqi AU - Ye P AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Fudan University, Shanghai 200032, China. FAU - Wei, Qian AU - Wei Q AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Fudan University, Shanghai 200032, China. AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Lanzhou University, Lanzhou 730000, China. FAU - Zou, Jiaojiao AU - Zou J AD - Department of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Fudan University, Shanghai 200032, China. FAU - Zhang, Yunhui AU - Zhang Y AD - Department of Environment Health, School of Public Health, Fudan University, Shanghai 200032, China. FAU - Shi, Huijing AU - Shi H AUID- ORCID: 0000-0003-2403-550X AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Fudan University, Shanghai 200032, China. LA - eng GR - 2019FY101004/Ministry of Science and Technology of China/ GR - 2021ZD01002/Technology Program of Fujian Health Commission/ PT - Journal Article PL - United States TA - J Clin Endocrinol Metab JT - The Journal of clinical endocrinology and metabolism JID - 0375362 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Child, Preschool MH - Child MH - Male MH - Prospective Studies MH - *Prenatal Exposure Delayed Effects/epidemiology MH - Adult MH - *Maternal Health MH - China/epidemiology MH - Cardiometabolic Risk Factors MH - *Cardiovascular Diseases/epidemiology MH - Body Mass Index MH - *Child Health MH - Blood Pressure MH - Exercise MH - Follow-Up Studies OTO - NOTNLM OT - cardiometabolic health OT - cohort study OT - intergenerational effect OT - maternal-offspring association EDAT- 2024/06/13 18:42 MHDA- 2025/04/23 06:26 CRDT- 2024/06/13 14:13 PHST- 2024/03/26 00:00 [received] PHST- 2025/04/23 06:26 [medline] PHST- 2024/06/13 18:42 [pubmed] PHST- 2024/06/13 14:13 [entrez] AID - 7693028 [pii] AID - 10.1210/clinem/dgae413 [doi] PST - ppublish SO - J Clin Endocrinol Metab. 2025 Apr 22;110(5):1434-1443. doi: 10.1210/clinem/dgae413. PMID- 38865107 OWN - NLM STAT- MEDLINE DCOM- 20240904 LR - 20260915 IS - 2168-6238 (Electronic) IS - 2168-622X (Print) IS - 2168-622X (Linking) VI - 81 IP - 9 DP - 2024 Sep 1 TI - Polygenic Scores and Networks of Psychopathology Symptoms. PG - 902-910 LID - 10.1001/jamapsychiatry.2024.1403 [doi] AB - IMPORTANCE: Studies on polygenic risk for psychiatric traits commonly use a disorder-level approach to phenotyping, implicitly considering disorders as homogeneous constructs; however, symptom heterogeneity is ubiquitous, with many possible combinations of symptoms falling under the same disorder umbrella. Focusing on individual symptoms may shed light on the role of polygenic risk in psychopathology. OBJECTIVE: To determine whether polygenic scores are associated with all symptoms of psychiatric disorders or with a subset of indicators and whether polygenic scores are associated with comorbid phenotypes via specific sets of relevant symptoms. DESIGN, SETTING, AND PARTICIPANTS: Data from 2 population-based cohort studies were used in this cross-sectional study. Data from children in the Avon Longitudinal Study of Parents and Children (ALSPAC) were included in the primary analysis, and data from children in the Twins Early Development Study (TEDS) were included in confirmatory analyses. Data analysis was conducted from October 2021 to January 2024. Pregnant women based in the Southwest of England due to deliver in 1991 to 1992 were recruited in ALSPAC. Twins born in 1994 to 1996 were recruited in TEDS from population-based records. Participants with available genetic data and whose mothers completed the Short Mood and Feelings Questionnaire and the Strength and Difficulties Questionnaire when children were 11 years of age were included. MAIN OUTCOMES AND MEASURES: Psychopathology relevant symptoms, such as hyperactivity, prosociality, depression, anxiety, and peer and conduct problems at age 11 years. Psychological networks were constructed including individual symptoms and polygenic scores for depression, anxiety, attention-deficit/hyperactivity disorder (ADHD), body mass index (BMI), and educational attainment in ALSPAC. Following a preregistered confirmatory analysis, network models were cross-validated in TEDS. RESULTS: Included were 5521 participants from ALSPAC (mean [SD] age, 11.8 [0.14] years; 2777 [50.3%] female) and 4625 participants from TEDS (mean [SD] age, 11.27 [0.69] years; 2460 [53.2%] female). Polygenic scores were preferentially associated with restricted subsets of core symptoms and indirectly associated with other, more distal symptoms of psychopathology (network edges ranged between r = -0.074 and r = 0.073). Psychiatric polygenic scores were associated with specific cross-disorder symptoms, and nonpsychiatric polygenic scores were associated with a variety of indicators across disorders, suggesting a potential contribution of nonpsychiatric traits to comorbidity. For example, the polygenic score for ADHD was associated with a core ADHD symptom, being easily distracted (r = 0.07), and the polygenic score for BMI was associated with symptoms across disorders, including being bullied (r = 0.053) and not thinking things out (r = 0.041). CONCLUSIONS AND RELEVANCE: Genetic associations observed at the disorder level may hide symptom-level heterogeneity. A symptom-level approach may enable a better understanding of the role of polygenic risk in shaping psychopathology and comorbidity. FAU - Piazza, Giulia G AU - Piazza GG AD - Department of Clinical, Educational and Health Psychology, University College London, London, United Kingdom. FAU - Allegrini, Andrea G AU - Allegrini AG AD - Department of Clinical, Educational and Health Psychology, University College London, London, United Kingdom. AD - Social Genetic and Developmental Psychiatry, King's College London, London, United Kingdom. FAU - Eley, Thalia C AU - Eley TC AD - Social Genetic and Developmental Psychiatry, King's College London, London, United Kingdom. FAU - Epskamp, Sacha AU - Epskamp S AD - Department of Psychology, National University of Singapore, Singapore. FAU - Fried, Eiko AU - Fried E AD - Department of Clinical Psychology, Leiden University, Leiden, the Netherlands. FAU - Isvoranu, Adela-Maria AU - Isvoranu AM AD - Department of Psychology, National University of Singapore, Singapore. FAU - Roiser, Jonathan P AU - Roiser JP AD - Institute of Cognitive Neuroscience, University College London, London, United Kingdom. FAU - Pingault, Jean-Baptiste AU - Pingault JB AD - Department of Clinical, Educational and Health Psychology, University College London, London, United Kingdom. AD - Social Genetic and Developmental Psychiatry, King's College London, London, United Kingdom. LA - eng GR - WT_/Wellcome Trust/United Kingdom PT - Journal Article PT - Observational Study PL - United States TA - JAMA Psychiatry JT - JAMA psychiatry JID - 101589550 SB - IM EIN - JAMA Psychiatry. 2024 Sep 1;81(9):948. doi: 10.1001/jamapsychiatry.2024.2537. PMID: 39230613 MH - Child MH - Female MH - Humans MH - Male MH - Cross-Sectional Studies MH - Longitudinal Studies MH - *Mental Disorders/genetics/epidemiology/psychology MH - *Multifactorial Inheritance/genetics MH - Phenotype MH - Psychopathology MH - Twin Studies as Topic PMC - PMC11170456 COIS- Conflict of Interest Disclosures: Dr Roiser reported grants from Cambridge Cognition Ltd (support for PhD studentship) and personal fees from GH Research (consultancy) outside the submitted work. No other disclosures were reported. EDAT- 2024/06/12 12:42 MHDA- 2024/09/04 12:41 PMCR- 2024/06/12 CRDT- 2024/06/12 11:32 PHST- 2024/09/04 12:41 [medline] PHST- 2024/06/12 12:42 [pubmed] PHST- 2024/06/12 11:32 [entrez] PHST- 2024/06/12 00:00 [pmc-release] AID - 2819863 [pii] AID - yoi240030 [pii] AID - 10.1001/jamapsychiatry.2024.1403 [doi] PST - ppublish SO - JAMA Psychiatry. 2024 Sep 1;81(9):902-910. doi: 10.1001/jamapsychiatry.2024.1403. PMID- 38864357 OWN - NLM STAT- MEDLINE DCOM- 20241023 LR - 20260512 IS - 1520-6300 (Electronic) IS - 1042-0533 (Linking) VI - 36 IP - 9 DP - 2024 Sep TI - Effects of family life cycle events on individual Body Mass Index trajectories: Evidence from China. PG - e24116 LID - 10.1002/ajhb.24116 [doi] AB - PURPOSE: Body mass index (BMI) is an important predictor of one's physiological health. China is a family-centric nation compared to Western societies and has already entered an aged society. Exploring the characteristics and patterns of BMI changes during household events in China provides critical insights into the biological and social determinants of health, which can help enhance the scientific validity of health promotion measures and contribute to the realization of healthy aging goals in China. METHODS: Using data from the China Health and Nutrition Survey (CHNS) from 1993 to 2015, this article utilizes two-level growth curve models with piecewise spline specifications for age to examine the effects of family life cycle events on BMI trajectories for age groups and gender differences. RESULTS: Compared to continuing status, experiencing transition in an individual's family life cycle could lead to more fluctuating variations in their BMI trajectories, generally, there is a faster increase in BMI during youth and a faster decline during old age. As for gender heterogeneity, males are more affected by divorce, widowhood, and empty nest, whereas females' BMI changes are influenced by entering/maintaining marriage and parenthood. CONCLUSIONS: A long-term perspective has revealed the significance of family events on BMI throughout the life course. Future research should focus on the nutrition and health of specific populations, especially elderly individuals in vulnerable groups. CI - (c) 2024 Wiley Periodicals LLC. FAU - Jiang, Yicen AU - Jiang Y AUID- ORCID: 0009-0002-5230-2054 AD - School of Social Development and Public Policy, Fudan University, Shanghai, China. AD - Fudan Institute on Aging, Fudan University, Shanghai, China. FAU - Zhu, Qin AU - Zhu Q AUID- ORCID: 0000-0001-6337-0779 AD - School of Social Development and Public Policy, Fudan University, Shanghai, China. AD - Fudan Institute on Aging, Fudan University, Shanghai, China. LA - eng GR - 21&ZD189/Major Project of the National Social Science Fund of China/ PT - Journal Article DEP - 20240612 PL - United States TA - Am J Hum Biol JT - American journal of human biology : the official journal of the Human Biology Council JID - 8915029 SB - IM MH - Humans MH - China MH - Male MH - *Body Mass Index MH - Female MH - Middle Aged MH - Adult MH - Aged MH - Young Adult MH - Aged, 80 and over MH - Adolescent MH - Sex Factors MH - Family Characteristics EDAT- 2024/06/12 12:42 MHDA- 2024/10/23 12:39 CRDT- 2024/06/12 06:23 PHST- 2024/05/30 00:00 [revised] PHST- 2024/03/13 00:00 [received] PHST- 2024/05/31 00:00 [accepted] PHST- 2024/10/23 12:39 [medline] PHST- 2024/06/12 12:42 [pubmed] PHST- 2024/06/12 06:23 [entrez] AID - 10.1002/ajhb.24116 [doi] PST - ppublish SO - Am J Hum Biol. 2024 Sep;36(9):e24116. doi: 10.1002/ajhb.24116. Epub 2024 Jun 12. PMID- 38864205 OWN - NLM STAT- MEDLINE DCOM- 20240612 LR - 20250512 IS - 2150-1327 (Electronic) IS - 2150-1319 (Print) IS - 2150-1319 (Linking) VI - 15 DP - 2024 Jan-Dec TI - Validity and Reliability of the Child and Adolescent Version of the Iron Intake Scale (CIIS) as an Educational Tool. PG - 21501319241259410 LID - 10.1177/21501319241259410 [doi] LID - 21501319241259410 AB - INTRODUCTION/OBJECTIVE: In Asia, 42% of young children suffer from iron deficiency anemia. Children have an increased requirement for iron intake because of growth and physical activity. Education plays an important role in anemia prevention and in ensuring children are aware of appropriate iron intake and the iron content of different foods. As a tool for this purpose, we adapted the adult version of the Revised Iron Intake Scale (RIIS) to create the Child and Adolescent Version of the Iron Intake Scale (CIIS), using illustrations to help children recognize the foods listed in the CIIS. We aimed to evaluate the validity and reliability of this new scale. METHODS: We conducted a cross-sectional study using a self-administered questionnaire to examine the criterion-related validity of the CIIS. We used Spearman's rank correlation coefficient to compare iron intake estimated by the CIIS with that calculated by the Brief-type Diet History Questionnaire (BDHQ-15y), which assesses respondents' dietary habits over the past month and is standardized among Japanese children. The survey was repeated twice to examine reliability. RESULTS: We found a moderate positive correlation for iron intake between the CIIS and BDHQ-15y, with a correlation coefficient of .52 (n = 258, P < .001). Cronbach's alpha coefficient was .718. The CIIS reproducibility test yielded a correlation coefficient of .67. CONCLUSION: Our results indicated that the CIIS was valid, reliable, and reproducible. We therefore believe that the scale can be used to improve education about iron deficiency anemia and thereby reduce anemia rates among children and adolescents. FAU - Okabe, Satoko AU - Okabe S AUID- ORCID: 0000-0003-2617-2049 AD - Koriyama Women's University, Fukushima, Japan. FAU - Ito, Shinya AU - Ito S AUID- ORCID: 0000-0001-8544-4871 AD - Kitasato University, Kanagawa, Japan. FAU - Kameta, Akemi AU - Kameta A AUID- ORCID: 0009-0008-6923-0281 AD - Koriyama Women's University, Fukushima, Japan. FAU - Goto, Aya AU - Goto A AUID- ORCID: 0000-0002-7927-7648 AD - Fukushima Medical University, Fukushima, Japan. AD - Harvard T. H. Chan School of Public Health, Boston, USA. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study PL - United States TA - J Prim Care Community Health JT - Journal of primary care & community health JID - 101518419 RN - 0 (Iron, Dietary) SB - IM MH - Humans MH - Cross-Sectional Studies MH - Child MH - Female MH - Male MH - Reproducibility of Results MH - Adolescent MH - *Anemia, Iron-Deficiency/prevention & control MH - Surveys and Questionnaires MH - Iron, Dietary/administration & dosage MH - Child, Preschool MH - Japan MH - Feeding Behavior PMC - PMC11177732 OTO - NOTNLM OT - Iron Intake Scale OT - anemia OT - iron deficiency OT - nutrition education COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2024/06/12 06:42 MHDA- 2024/06/12 06:43 PMCR- 2024/06/12 CRDT- 2024/06/12 05:02 PHST- 2024/06/12 06:43 [medline] PHST- 2024/06/12 06:42 [pubmed] PHST- 2024/06/12 05:02 [entrez] PHST- 2024/06/12 00:00 [pmc-release] AID - 10.1177_21501319241259410 [pii] AID - 10.1177/21501319241259410 [doi] PST - ppublish SO - J Prim Care Community Health. 2024 Jan-Dec;15:21501319241259410. doi: 10.1177/21501319241259410. PMID- 38864174 OWN - NLM STAT- MEDLINE DCOM- 20241119 LR - 20260708 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 20 IP - 4 DP - 2024 Oct TI - Identifying measures for coverage of nutrition-sensitive social protection programs: Learnings from India. PG - e13661 LID - 10.1111/mcn.13661 [doi] LID - e13661 AB - Optimal child growth requires a combination of nutrition-specific and sensitive interventions in the first 1,000 days. There is limited guidance on how to measure the population-level coverage of nutrition-sensitive social protection (NSSP), which is designed with explicit nutrition goals and often provides food or cash transfers and co-coverage with nutrition and health intervention. In this study in India, we designed a questionnaire that captures seven core NSSP program elements (transfer type, size, modality, population, timing, provider, conditionalities), then used cognitive testing to refine the questionnaire, and then implemented the questions as part of a telephone survey. Cognitive testing indicated variability in understanding the terms used to specify NSSP programs, including the need to use regional program names. Respondents also had difficulty recalling the timing of the benefit receipt. We included the refined NSSP coverage questions in a phone-based survey with 6,627 mothers with children <2 years across six states. Coverage of subsidized food was 73% across all households. Women were more likely to report receiving food than cash transfers during pregnancy (89% vs. 60%) and during lactation (75% vs. 13%). Co-coverage of NSSP with nutrition and health interventions during pregnancy (16%) and early childhood (3%) was low. It was feasible to measure coverage of NSSP investments in these populations; however, further research is needed to comprehensively assess all the dimensions of the NSSP benefits, including benefit adequacy and the validity of these questions when administered in person and by phone. CI - (c) 2024 The Authors. Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Nguyen, Phuong Hong AU - Nguyen PH AUID- ORCID: 0000-0003-3418-1674 AD - International Food Policy Research Institute, Washington, D.C., USA. FAU - Avula, Rasmi AU - Avula R AD - International Food Policy Research Institute, Washington, D.C., USA. FAU - Neupane, Sumanta AU - Neupane S AUID- ORCID: 0000-0003-2977-0896 AD - International Food Policy Research Institute, Washington, D.C., USA. FAU - Akseer, Nadia AU - Akseer N AD - Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Heidkamp, Rebecca AU - Heidkamp R AUID- ORCID: 0000-0003-3146-1320 AD - Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. LA - eng GR - GATES/Gates Foundation/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240612 PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - India MH - Female MH - Infant MH - Surveys and Questionnaires MH - Adult MH - *Food Assistance MH - Nutritional Status MH - Pregnancy MH - Male MH - Infant, Newborn MH - Young Adult PMC - PMC11574639 OTO - NOTNLM OT - coverage measurement OT - measurement OT - nutrition-sensitive social protection COIS- The authors declare that they have no conflicts of interest. EDAT- 2024/06/12 06:42 MHDA- 2024/11/19 13:18 PMCR- 2024/06/12 CRDT- 2024/06/12 04:43 PHST- 2024/03/28 00:00 [revised] PHST- 2023/06/14 00:00 [received] PHST- 2024/04/25 00:00 [accepted] PHST- 2024/11/19 13:18 [medline] PHST- 2024/06/12 06:42 [pubmed] PHST- 2024/06/12 04:43 [entrez] PHST- 2024/06/12 00:00 [pmc-release] AID - MCN13661 [pii] AID - 10.1111/mcn.13661 [doi] PST - ppublish SO - Matern Child Nutr. 2024 Oct;20(4):e13661. doi: 10.1111/mcn.13661. Epub 2024 Jun 12. PMID- 38861761 OWN - NLM STAT- MEDLINE DCOM- 20240728 LR - 20240728 IS - 1873-2364 (Electronic) IS - 0960-8966 (Linking) VI - 41 DP - 2024 Aug TI - Exploring functional strength changes during nusinersen treatment in symptomatic children with SMA types 2 and 3. PG - 1-7 LID - S0960-8966(24)00108-1 [pii] LID - 10.1016/j.nmd.2024.05.011 [doi] AB - The Hammersmith Functional Motor Scale-Expanded (HFMSE) is a validated outcome measure for monitoring changes in functional strength in patients with spinal muscular atrophy (SMA). The objective of this study was to explore changes in HFMSE item-scores in children with SMA types 2 and 3a treated with nusinersen over a period of six to twenty months. We stratified patients according to motor ability (sitting and walking), and calculated numbers and percentages for each specific improvement (positive score change) or decrease (negative score change) for the total group and each subgroup and calculated frequency distributions of specific score changes. Ninety-one percent of the children showed improvement in at least 1 item, twenty-eight percent showed a score decrease in 1 or more items. In the first six to twenty months of nusinersen treatment motor function change was characterized by the acquisition of the ability to perform specific tasks with compensation strategies (score changes from 0 to 1). Children with the ability to sit were most likely to improve in items that assess rolling, whilst children with the ability to walk most likely improved in items that assess half-kneeling. The ability most frequently lost was hip flexion in supine position. CI - Copyright (c) 2024 The Authors. Published by Elsevier B.V. All rights reserved. FAU - van der Woude, Danny R AU - van der Woude DR AD - Child Development and Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Lundlaan 6, 3584 EA Utrecht, the Netherlands. FAU - Wadman, Renske I AU - Wadman RI AD - Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, 3584 CX, Utrecht, the Netherlands. FAU - Asselman, Fay-Lynn AU - Asselman FL AD - Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, 3584 CX, Utrecht, the Netherlands. FAU - Schoenmakers, Marja A G C AU - Schoenmakers MAGC AD - Child Development and Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Lundlaan 6, 3584 EA Utrecht, the Netherlands. FAU - Cuppen, Inge AU - Cuppen I AD - Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, 3584 CX, Utrecht, the Netherlands. FAU - van der Pol, W Ludo AU - van der Pol WL AD - Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, 3584 CX, Utrecht, the Netherlands. FAU - Bartels, Bart AU - Bartels B AD - Child Development and Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Lundlaan 6, 3584 EA Utrecht, the Netherlands. Electronic address: b.bartels-4@umcutrecht.nl. LA - eng PT - Journal Article DEP - 20240523 PL - England TA - Neuromuscul Disord JT - Neuromuscular disorders : NMD JID - 9111470 RN - 5Z9SP3X666 (nusinersen) RN - 0 (Oligonucleotides) SB - IM MH - Humans MH - *Oligonucleotides/pharmacology/therapeutic use MH - Male MH - Female MH - *Spinal Muscular Atrophies of Childhood/drug therapy/physiopathology MH - Child, Preschool MH - Child MH - Walking/physiology MH - Treatment Outcome MH - Muscle Strength/drug effects MH - Infant OTO - NOTNLM OT - HFMSE OT - Motor function OT - Nusinersen OT - Spinal muscular atrophy OT - Treatment COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Danny R. van der Woude, his employer receives fees for SMA-related consultancy activities. Renske I Wadman, Research grants from Prinses Beatrix Spierfonds and Stichting Spieren voor Spieren, both non-profit foundations. Her employer receives fees for SMA-related consultancy activities. Fay-Lynn Asselman, her employer receives fees for SMA-related consultancy activities. Marja A.G.C. Schoenmakers, no conflicts of interest. Inge Cuppen, her employer receives fees for SMA-related consultancy activities. W Ludo van der Pol, Research grants from Prinses Beatrix Spierfonds and Stichting Spieren voor Spieren, both non-profit foundations. His-employer receives fees for SMA-related consultancy activities. Bart Bartels, Research grants from Prinses Beatrix Spierfonds, Stichting Spieren voor Spieren and Piet Poortmanfonds, all non-profit foundations. His-employer receives fees for SMA-related consultancy activities. EDAT- 2024/06/11 18:42 MHDA- 2024/07/29 00:42 CRDT- 2024/06/11 17:59 PHST- 2024/04/24 00:00 [received] PHST- 2024/05/22 00:00 [revised] PHST- 2024/05/23 00:00 [accepted] PHST- 2024/07/29 00:42 [medline] PHST- 2024/06/11 18:42 [pubmed] PHST- 2024/06/11 17:59 [entrez] AID - S0960-8966(24)00108-1 [pii] AID - 10.1016/j.nmd.2024.05.011 [doi] PST - ppublish SO - Neuromuscul Disord. 2024 Aug;41:1-7. doi: 10.1016/j.nmd.2024.05.011. Epub 2024 May 23. PMID- 38861515 OWN - NLM STAT- MEDLINE DCOM- 20250303 LR - 20260806 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 6 DP - 2024 TI - Maternal concern and perception about child overweight risk, maternal feeding practices, and child eating behaviors: A cross-sectional study. PG - e0302557 LID - 10.1371/journal.pone.0302557 [doi] LID - e0302557 AB - Abundant efforts have been directed to understand the global obesity epidemic and related obesogenic behaviors. However, the relationships of maternal concern and perception about child weight with child eating behaviors in Saudi Arabia have not been investigated. Therefore, this study aimed to examine the associations of maternal concern and perception about child overweight risk with maternal feeding practices and child eating behaviors among mothers and their children in Saudi Arabia. Mothers of 115 children aged 3-5 years old were recruited from eight preschools. Child eating behaviors (enjoyment of food, responsiveness to foods, food fussiness, satiety responsiveness, and slowness in eating) and maternal feeding practices (restriction, monitoring, and using food as a reward), maternal concern about child weight, and maternal perception about child overweight risk were assessed using validated questionnaires. Multiple linear regression models, adjusted for maternal body mass index (BMI) and child's BMI-z score and sex, were tested to examine the independent associations of maternal concern and perception about child overweight risk with child eating behaviors and maternal feeding practices. Maternal concern about child weight was positively associated with food enjoyment in children (B = 0.14 [95% confidence intervals = 0.02,0.27]) and responsiveness to food (B = 0.16 [0.03,0.29]), whereas a negative association with child food fussiness was observed (B = -0.19 [-0.33, -0.04]). Maternal perception about child overweight risk and child slowness in eating were negatively associated (B = -0.72 [-0.16 to -0.28]). Maternal concern and perception about child overweight risk were not associated with maternal feeding practices. In conclusion, maternal concern and perception about child overweight risk were found to be associated with food approach eating behavior traits but not with maternal feeding practices. Mothers who are concerned about child weight or perceive their children as overweight may need guidance and support to promote healthy eating behaviors among their children. Future cross-cultural studies are needed to understand the underlying mechanisms for the influence of maternal concern and perception about child overweight risk on maternal feeding practices, child eating behaviors, and weight status of children. CI - Copyright: (c) 2024 Kutbi, Mosli. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Kutbi, Hebah Alawi AU - Kutbi HA AUID- ORCID: 0000-0002-2687-2515 AD - Department of Clinical Nutrition, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Mosli, Rana Hisham AU - Mosli RH AD - Department of Clinical Nutrition, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. LA - eng PT - Journal Article DEP - 20240611 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - *Mothers/psychology MH - *Overweight/epidemiology MH - *Feeding Behavior MH - Cross-Sectional Studies MH - Mother-Child Relations/psychology MH - Perception MH - Humans MH - Saudi Arabia/epidemiology MH - Male MH - Female MH - Child, Preschool MH - Food Fussiness MH - Pediatric Obesity/epidemiology MH - Young Adult MH - Adult MH - Middle Aged MH - Body Mass Index PMC - PMC11166278 COIS- The authors have declared that no competing interests exist. EDAT- 2024/06/11 18:42 MHDA- 2024/06/11 18:43 PMCR- 2024/06/11 CRDT- 2024/06/11 13:33 PHST- 2022/12/26 00:00 [received] PHST- 2024/04/07 00:00 [accepted] PHST- 2024/06/11 18:43 [medline] PHST- 2024/06/11 18:42 [pubmed] PHST- 2024/06/11 13:33 [entrez] PHST- 2024/06/11 00:00 [pmc-release] AID - PONE-D-22-35341 [pii] AID - 10.1371/journal.pone.0302557 [doi] PST - epublish SO - PLoS One. 2024 Jun 11;19(6):e0302557. doi: 10.1371/journal.pone.0302557. eCollection 2024. PMID- 38860870 OWN - NLM STAT- MEDLINE DCOM- 20240611 LR - 20260127 IS - 1550-2783 (Electronic) IS - 1550-2783 (Linking) VI - 21 IP - 1 DP - 2024 Dec TI - Differences in perceived energy and macronutrient requirements across divisions in NCAA athletes. PG - 2365307 LID - 10.1080/15502783.2024.2365307 [doi] LID - 2365307 AB - BACKGROUND: Sports nutrition is an impactful component to sports performance. The purpose of the current study was to investigate the sports nutrition knowledge of National Collegiate Athletic Association collegiate athletes and assess self-reported perceived requirements for energy and macronutrient intake. A secondary aim was to evaluate the awareness of physical and emotional perceptions associated with mindful eating. METHODS: Participants included NCAA Division I (DI, n = 45), II (DII, n = 31), and III (DIII, n = 47) athletes. Athletes completed a validated questionnaire designed to assess sports nutrition knowledge and were asked questions about their perceived dietary energy and macronutrient requirements. Daily energy intake values were calculated using a recommended relative energy intake value of 40, 50, and 60 kcal/kg/day for low, moderate, and high activity levels, respectively. Carbohydrate recommendations were calculated using 4, 6, and 8 g/kg/day, protein recommendations were calculated using relative intakes of 1.4, 1.6, and 1.8 g/kg/day, and fat recommendations were calculated from a relative percentage of total predicted daily energy requirements, equating to 15, 25, and 30% of daily energy. Additionally, athletes completed a questionnaire to assess mindfulness regarding eating habits. RESULTS: Overall, athletes answered 45.5 +/- 13.5% of questions correctly on the nutrition questionnaire with significant differences observed between male (48.6 +/- 13.6%) and female athletes (43.6 +/- 13.2%; p = 0.044), as well as significant differences observed between DI athlete scores (38.8 +/- 14.1%) and DII athletes (47.7 +/- 11.4%; p = 0.002), and DI athletes and DIII athletes (51.71 +/- 11.83%; p = <0.001). All athletes significantly (p < 0.001) underestimated daily energy intake requirements (female, 2,112 +/- 575 kcal/day; male, 3,283 +/- 538 kcal/day). The mindfulness eating habits total score was significantly higher in male athletes (65.1 +/- 6.5) compared to female athletes (60.9 +/- 9.5; p = 0.009). CONCLUSIONS: Division I, II, and III collegiate athletes have poor sports nutrition knowledge, with Division I athletes having exhibited lower scores compared to Division II and III athletes on the sports nutrition knowledge questionnaire. Athletes from all levels of collegiate sports underestimated their energy and macronutrient requirements. Differences in mindful eating habits among female and male athletes were also evident. FAU - Singleton, K Michelle AU - Singleton KM AUID- ORCID: 0000-0001-8258-0544 AD - Department of Kinesiology, Conway Medical Center College of Health & Human Performance, Coastal Carolina University, Conway, SC, USA. FAU - Jagim, Andrew R AU - Jagim AR AUID- ORCID: 0000-0002-6651-5096 AD - Sports Medicine, Mayo Clinic Health System, La Crosse, WI, USA. AD - University of Wisconsin-La Crosse, La Crosse, WI, USA. FAU - McAllister-Deitrick, Jamie AU - McAllister-Deitrick J AD - Department of Kinesiology, Conway Medical Center College of Health & Human Performance, Coastal Carolina University, Conway, SC, USA. FAU - Daou, Marcos AU - Daou M AD - Department of Kinesiology, Conway Medical Center College of Health & Human Performance, Coastal Carolina University, Conway, SC, USA. FAU - Kerksick, Chad M AU - Kerksick CM AUID- ORCID: 0000-0003-0458-7294 AD - Sports Medicine, Mayo Clinic Health System, La Crosse, WI, USA. AD - Exercise and Performance Nutrition Laboratory, Department of Kinesiology, College of Science, Technology, and Health, Lindenwood University, St Charles, MO, USA. LA - eng PT - Journal Article DEP - 20240611 PL - United States TA - J Int Soc Sports Nutr JT - Journal of the International Society of Sports Nutrition JID - 101234168 RN - 0 (Nutrients) RN - 0 (Dietary Carbohydrates) RN - 0 (Dietary Proteins) RN - 0 (Dietary Fats) SB - IM MH - Humans MH - Female MH - Male MH - *Energy Intake MH - *Sports Nutritional Physiological Phenomena MH - *Nutritional Requirements MH - Young Adult MH - *Athletes/psychology MH - Surveys and Questionnaires MH - *Feeding Behavior MH - *Health Knowledge, Attitudes, Practice MH - Nutrients/administration & dosage MH - Dietary Carbohydrates/administration & dosage MH - Dietary Proteins/administration & dosage MH - Adolescent MH - Dietary Fats/administration & dosage MH - Mindfulness MH - Self Report PMC - PMC11168329 OTO - NOTNLM OT - Sports nutrition knowledge OT - energy intake OT - macronutrient intake OT - mindful eating habits COIS- No potential conflict of interest was reported by the author(s). EDAT- 2024/06/11 12:44 MHDA- 2024/06/11 12:45 PMCR- 2024/06/11 CRDT- 2024/06/11 09:43 PHST- 2024/06/11 12:45 [medline] PHST- 2024/06/11 12:44 [pubmed] PHST- 2024/06/11 09:43 [entrez] PHST- 2024/06/11 00:00 [pmc-release] AID - 2365307 [pii] AID - 10.1080/15502783.2024.2365307 [doi] PST - ppublish SO - J Int Soc Sports Nutr. 2024 Dec;21(1):2365307. doi: 10.1080/15502783.2024.2365307. Epub 2024 Jun 11. PMID- 38860401 OWN - NLM STAT- MEDLINE DCOM- 20240618 LR - 20260925 IS - 2047-9980 (Electronic) IS - 2047-9980 (Linking) VI - 13 IP - 12 DP - 2024 Jun 18 TI - Development and Validation of a Mortality Risk Score for Repaired Tetralogy of Fallot. PG - e034871 LID - 10.1161/JAHA.123.034871 [doi] LID - e034871 AB - BACKGROUND: Robust risk assessment is crucial for the growing repaired tetralogy of Fallot population at risk of major adverse clinical outcomes; however, current tools are hindered by lack of validation. This study aims to develop and validate a risk prediction model for death in the repaired tetralogy of Fallot population. METHODS AND RESULTS: Patients with repaired tetralogy of Fallot enrolled in the INDICATOR (International Multicenter Tetralogy of Fallot Registry) cohort with clinical, arrhythmia, cardiac magnetic resonance, and outcome data were included. Patients from London, Amsterdam, and Boston sites were placed in the development cohort; patients from the Toronto site were used for external validation. Multivariable Cox regression was used to evaluate factors associated with time from cardiac magnetic resonance until the primary outcome: all-cause death. Of 1552 eligible patients (n=1221 in development, n=331 in validation; median age at cardiac magnetic resonance 23.4 [interquartile range, 15.6-35.6] years; median follow up 9.5 years), 102 (6.6%) experienced the primary outcome. The multivariable Cox model performed similarly during development (concordance index, 0.83 [95% CI, 0.78-0.88]) and external validation (concordance index, 0.80 [95% CI, 0.71-0.90]) and identified older age at cardiac magnetic resonance, obesity, type of tetralogy of Fallot repair, higher right ventricular end-systolic volume index, and lower biventricular global function index as independent predictors of death. A risk-scoring algorithm dividing patients into low-risk (score 4) groups was validated to effectively discriminate risk of death (15-year survival of 95% versus 74%, respectively; P<0.001). CONCLUSIONS: This externally validated mortality risk prediction algorithm can help identify vulnerable patients with repaired tetralogy of Fallot who may benefit from targeted interventions. FAU - Mayourian, Joshua AU - Mayourian J AD - Department of Cardiology, Boston Children's Hospital, Department of Pediatrics Harvard Medical School Boston MA USA. FAU - Sleeper, Lynn A AU - Sleeper LA AUID- ORCID: 0000-0002-8055-768X AD - Department of Cardiology, Boston Children's Hospital, Department of Pediatrics Harvard Medical School Boston MA USA. FAU - Lee, Ji Hae AU - Lee JH AUID- ORCID: 0000-0003-4246-3524 AD - Department of Cardiology, Boston Children's Hospital, Department of Pediatrics Harvard Medical School Boston MA USA. FAU - Lu, Minmin AU - Lu M AD - Department of Cardiology, Boston Children's Hospital, Department of Pediatrics Harvard Medical School Boston MA USA. FAU - Geva, Alon AU - Geva A AUID- ORCID: 0000-0002-8574-0133 AD - Department of Anesthesiology, Critical Care, and Pain Medicine, and Computational Health Informatics Program, Boston Children's Hospital and Department of Anaesthesia Harvard Medical School Boston MA USA. FAU - Mulder, Barbara AU - Mulder B AD - Department of Cardiology Amsterdam University Medical Centre Amsterdam The Netherlands. FAU - Babu-Narayan, Sonya V AU - Babu-Narayan SV AUID- ORCID: 0000-0002-1558-8447 AD - Royal Brompton and Harefield NHS Foundation Trust National Heart and Lung Institute, Imperial College London United Kingdom. FAU - Wald, Rachel M AU - Wald RM AUID- ORCID: 0000-0002-2373-6438 AD - Division of Cardiology University of Toronto, Peter Munk Cardiac Centre Toronto ON Canada. FAU - Sompolinsky, Tehila AU - Sompolinsky T AUID- ORCID: 0009-0003-6069-6177 AD - Department of Cardiology, Boston Children's Hospital, Department of Pediatrics Harvard Medical School Boston MA USA. FAU - Valente, Anne Marie AU - Valente AM AUID- ORCID: 0000-0002-8357-694X AD - Department of Cardiology, Boston Children's Hospital, Department of Pediatrics Harvard Medical School Boston MA USA. FAU - Geva, Tal AU - Geva T AUID- ORCID: 0000-0002-3538-1865 AD - Department of Cardiology, Boston Children's Hospital, Department of Pediatrics Harvard Medical School Boston MA USA. LA - eng GR - T32 GM146636/GM/NIGMS NIH HHS/United States GR - U01 HL098147/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Multicenter Study PT - Research Support, N.I.H., Extramural PT - Validation Study DEP - 20240611 PL - England TA - J Am Heart Assoc JT - Journal of the American Heart Association JID - 101580524 SB - IM EIN - J Am Heart Assoc. 2026 Oct 6;15(19):e045419. doi: 10.1161/JAHA.125.045419. PMID: 42786620 MH - Humans MH - *Tetralogy of Fallot/surgery/mortality MH - Male MH - Female MH - Risk Assessment/methods MH - Adult MH - Adolescent MH - Young Adult MH - *Registries MH - Risk Factors MH - Cardiac Surgical Procedures/adverse effects/mortality MH - Reproducibility of Results MH - Time Factors MH - Predictive Value of Tests MH - Cause of Death PMC - PMC11255736 OTO - NOTNLM OT - cardiovascular magnetic resonance OT - congenital heart disease OT - death OT - outcomes OT - risk score OT - tetralogy of Fallot OT - ventricular function EDAT- 2024/06/11 06:42 MHDA- 2024/06/18 19:18 PMCR- 2024/06/18 CRDT- 2024/06/11 05:13 PHST- 2024/06/18 19:18 [medline] PHST- 2024/06/11 06:42 [pubmed] PHST- 2024/06/11 05:13 [entrez] PHST- 2024/06/18 00:00 [pmc-release] AID - JAH39702 [pii] AID - 10.1161/JAHA.123.034871 [doi] PST - ppublish SO - J Am Heart Assoc. 2024 Jun 18;13(12):e034871. doi: 10.1161/JAHA.123.034871. Epub 2024 Jun 11. PMID- 38860329 OWN - NLM STAT- MEDLINE DCOM- 20250911 LR - 20250913 IS - 2047-945X (Electronic) IS - 0260-1060 (Print) IS - 0260-1060 (Linking) VI - 31 IP - 3 DP - 2025 Sep TI - Development of a bioelectrical impedance analysis-based prediction equation for body composition of rural children aged 4-8 years in Myanmar. PG - 933-942 LID - 10.1177/02601060241260983 [doi] AB - Background: Reliable and accurate estimates of body composition are essential when studying the various health correlates of disease. Bioelectrical impedance analysis (BIA) is an affordable and feasible body composition assessment technique for clinical and field settings. Total body water (TBW) and hence fat-free mass is estimated by predictive regression algorithms using anthropometric measurements plus the resistance index. Aim: The study aimed to develop a BIA prediction equation for TBW in children in Myanmar using the deuterium dilution technique as the reference method. Methods: The study design was cross-sectional in a school setting with convenience sampling of participants. One hundred and two healthy children (57 boys and 45 girls) with aged 4 and 8 years participated; randomly divided into the prediction group (29 boys and 22 girls) and cross-validation group (28 boys and 23 girls). Whole-body impedance, anthropometric and TBW (by D(2)O dilution) measurements. The prediction equation was cross-validated using a split-group design and compared to published equations for contemporaneous populations. Results: TBW could be predicted by the following equation. TBW = 0.4597 * Weight (kg) + 0.1564 * Impedance index + 0.6075 (R(2) = 0.891, P < 0.0001) with a correlation coefficient of 0.942 and limits of agreement of 0.98 kg TBW on cross-validation. Conclusions: This equation can be used to predict body composition in young (aged 4-8 years) children in Myanmar but because the age range of the participants in the present study was relatively narrow, more research in different age groups is required to establish its broader applicability. FAU - Maw, Aye Aye AU - Maw AA AD - Department of Medical Research, Myanmar Ministry of Health and Sports, Yangon, Myanmar. RINGGOLD: 519388 FAU - Thwin, Theingi AU - Thwin T AD - Department of Medical Research, Myanmar Ministry of Health and Sports, Yangon, Myanmar. RINGGOLD: 519388 FAU - Owino, Victor O AU - Owino VO AD - Division of Human Health, International Atomic Energy Agency, Vienna, Austria. FAU - Ward, Leigh C AU - Ward LC AUID- ORCID: 0000-0003-2378-279X AD - School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia. LA - eng PT - Journal Article DEP - 20240611 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 SB - IM MH - Humans MH - *Electric Impedance MH - Myanmar MH - *Body Composition MH - Female MH - Child MH - Male MH - Child, Preschool MH - Cross-Sectional Studies MH - *Rural Population MH - Body Water MH - Anthropometry/methods MH - Reproducibility of Results PMC - PMC12423468 OTO - NOTNLM OT - Body composition OT - Myanmar children OT - bioelectrical impedance analysis OT - bioelectrical impedance analysis (BIA) OT - deuterium dilution COIS- Declaration of conflicting interestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Author Ward provides consultancy services to ImpediMed Ltd, manufacturer of impedance devices. ImpediMed had no input into the design, conduct or reporting of this study. All other authors have no conflicts to declare. EDAT- 2024/06/11 06:42 MHDA- 2025/09/11 12:31 PMCR- 2025/09/11 CRDT- 2024/06/11 04:33 PHST- 2025/09/11 12:31 [medline] PHST- 2024/06/11 06:42 [pubmed] PHST- 2024/06/11 04:33 [entrez] PHST- 2025/09/11 00:00 [pmc-release] AID - 10.1177_02601060241260983 [pii] AID - 10.1177/02601060241260983 [doi] PST - ppublish SO - Nutr Health. 2025 Sep;31(3):933-942. doi: 10.1177/02601060241260983. Epub 2024 Jun 11. PMID- 38859892 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250314 IS - 1939-795X (Print) IS - 1939-795X (Electronic) IS - 1939-795X (Linking) VI - 17 IP - 7 DP - 2024 TI - Comparison of Physical Activity Measured by Self-Reported Physical Activity and Wearable Device Xiaomi MI2 Band in Preadolescent School Children - A Pilot Cross-Sectional Study. PG - 565-575 AB - The purpose of this study is to compare physical activity measured by the wearable device Xiaomi Mi2 Band and self-reported physical activity by YPAQ in preadolescent school children. A pilot cross-sectional study was performed on a subsample (5%=n=60) of preadolescent children within a parallel-group feasibility intervention trial (n=1000). All children aged 9-11 years enrolled in the schools were included in the study and children with any physical disability were excluded. Self-reported physical activity was recorded through the modified version of the Youth Physical Activity Questionnaire (YPAQ) and automatic physical activity was measured by the Xiaomi Mi2 band over 7 days. Data from the Xiaomi Mi2 band was synchronized with its mobile application from where data was transferred to an excel sheet. Data on 7-day total physical activity in minutes and 7-day total step count were recorded by the Xiaomi Mi2 band. Student's t-tests were used to determine whether significant differences were present between self-reported physical activity and by Xiaomi Mi2 band. A Bland-Altman method was also used to assess the degree of agreement between the two methods of measuring physical activity. Mean +/- SD age of the children was 9.6 (+/- 1.0) years and 31 (51.7 %) were boys. The mean +/- SD time spent in physical activity reported by YPAQ was 457.5 (+/- 136) minutes and by the Xiaomi Mi2 band was 594.7 (+/- 183) minutes. The Bland-Altman plot identified a mean bias between the methods (YPAQ and Xiaomi Mi2 band) of -157.6 (95% CI: 296.3, -611.0) minutes of 7-day physical activity. Physical activity measured by a wearable device, the Xiaomi Mi2 band can give overestimated values of physical activity compared to self-reported physical activity in preadolescent school children. However, when PA is measured through step counts by the Xiaomi Mi2 band converted to minutes, it is comparable to PA measured by YPAQ. FAU - Almas, Aysha AU - Almas A AD - Department of Medicine, Aga Khan University, Karachi, PAKISTAN. FAU - Hashmi, Shiraz AU - Hashmi S AD - Department of Surgery, Aga Khan University, Karachi, PAKISTAN. FAU - Elahi, Adil AU - Elahi A AD - Research Fellow, Aga Khan University, Karachi, PAKISTAN. FAU - Parkash, O M AU - Parkash OM AD - Department of Medicine, Aga Khan University, Karachi, PAKISTAN. FAU - Sabir, Sania AU - Sabir S AD - Department of Medicine, Aga Khan University, Karachi, PAKISTAN. FAU - Iqbal, Romaina AU - Iqbal R AD - Department of Community Health Sciences, Aga Khan University, Karachi, PAKISTAN. LA - eng PT - Journal Article DEP - 20240401 PL - United States TA - Int J Exerc Sci JT - International journal of exercise science JID - 101513127 PMC - PMC11164430 OTO - NOTNLM OT - Adolescents OT - measurement OT - technology OT - youth physical activity questionnaire EDAT- 2024/06/11 06:42 MHDA- 2024/06/11 06:43 PMCR- 2024/04/01 CRDT- 2024/06/11 03:55 PHST- 2024/06/11 06:43 [medline] PHST- 2024/06/11 06:42 [pubmed] PHST- 2024/06/11 03:55 [entrez] PHST- 2024/04/01 00:00 [pmc-release] AID - ijes-17-7-565 [pii] AID - 10.70252/JACS9712 [doi] PST - epublish SO - Int J Exerc Sci. 2024 Apr 1;17(7):565-575. doi: 10.70252/JACS9712. eCollection 2024. PMID- 38858267 OWN - NLM STAT- In-Process LR - 20261009 IS - 1432-0932 (Electronic) IS - 0940-6719 (Linking) VI - 35 IP - 2 DP - 2026 Feb TI - Risk stratification for early postoperative infection in Pediatric spinal deformity correction: development and validation of the Pediatric scoliosis infection risk score (PSIR score). PG - 644-653 LID - 10.1007/s00586-024-08359-7 [doi] AB - BACKGROUND CONTEXT: Postoperative infection after spinal deformity correction in pediatric patients is associated with significant costs. Identifying risk factors associated with postoperative infection would help surgeons identify high-risk patients that may require interventions to minimize infection risk. PURPOSE: To investigate risk factors associated with 30-day postoperative infection in pediatric patients who have received posterior arthrodesis for spinal deformity correction. STUDY DESIGN/SETTING: Retrospective review of prospectively collected data. PATIENT SAMPLE: The National Surgical Quality Improvement Program Pediatric database for years 2016-2021 was used for this study. Patients were included if they received posterior arthrodesis for scoliosis or kyphosis correction (CPT 22,800, 22,802, 22,804). Anterior only approaches were excluded. OUTCOME MEASURES: TThe outcome of interest was 30-day postoperative infection. METHODS: Patient demographics and outcomes were analyzed using descriptive statistics. Multivariable logistic regression analysis using likelihood ratio backward selection method was used to identify significant risk factors for 30-day infection to create the Pediatric Scoliosis Infection Risk Score (PSIR Score). ROC curve analysis, predicted probabilities, and Hosmer Lemeshow goodness-of-fit test were done to assess the scoring system on a validation cohort. RESULTS: A total of 31,742 patients were included in the study. The mean age was 13.8 years and 68.7% were female. The 30-day infection rate was 2.2%. Reoperation rate in patients who had a post-operative infection was 59.4%. Patients who had post-operative infection had a higher likelihood of non-home discharge (X2 = 124.8, p < 0.001). In our multivariable regression analysis, high BMI (OR = 1.01, p < 0.001), presence of open wound (OR = 3.18, p < 0.001), presence of ostomy (OR = 1.51, p < 0.001), neuromuscular etiology (OR = 1.56, p = 0.009), previous operation (OR = 1.74, p < 0.001), increasing ASA class (OR = 1.43, p < 0.001), increasing operation time in hours (OR = 1.11, p < 0.001), and use of only minimally invasive techniques (OR = 4.26, p < 0.001) were associated with increased risk of 30-day post-operative infection. Idiopathic etiology (OR = 0.53, p < 0.001) and intraoperative topical antibiotic use (B = 0.71, p = 0.003) were associated with reduced risk of 30-day postoperative infection. The area under the curve was 0.780 and 0.740 for the derivation cohort and validation cohort, respectively. CONCLUSIONS: To our knowledge, this is the largest study of risk factors for infection in pediatric spinal deformity surgery. We found 5 patient factors (BMI, ASA, osteotomy, etiology, and previous surgery, and 3 surgeon-controlled factors (surgical time, antibiotics, MIS) associated with risk. The Pediatric Scoliosis Infection Risk Score (PSIR) Score can be applied for risk stratification and to investigate implementation of novel protocols to reduce infection rates in high-risk patients. CI - (c) 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Chan, Vivien AU - Chan V AD - UCLA Health, 1131 Wilshire Blvd Suite 100, Los Angeles Santa Monica, CA, 90401, USA. vivienka@ualberta.ca. FAU - Shumilak, Geoffrey AU - Shumilak G AD - University of Saskatchewan, Saskatoon, SK, Canada. FAU - Jafari, Matiar AU - Jafari M AD - UCLA Health, 1131 Wilshire Blvd Suite 100, Los Angeles Santa Monica, CA, 90401, USA. FAU - Fehlings, Michael G AU - Fehlings MG AD - University of Toronto, Toronto, ON, Canada. FAU - Yang, Michael M H AU - Yang MMH AD - University of Calgary, Calgary, AB, Canada. FAU - Skaggs, David L AU - Skaggs DL AD - Spine Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA. LA - eng PT - Journal Article DEP - 20240610 PL - Germany TA - Eur Spine J JT - European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society JID - 9301980 SB - IM OTO - NOTNLM OT - Pediatric OT - Postoperative infection OT - Prediction model OT - Risk stratification OT - Scoliosis EDAT- 2024/06/11 00:42 MHDA- 2024/06/11 00:42 CRDT- 2024/06/10 23:14 PHST- 2024/03/08 00:00 [received] PHST- 2024/06/02 00:00 [accepted] PHST- 2024/04/21 00:00 [revised] PHST- 2024/06/11 00:42 [pubmed] PHST- 2024/06/11 00:42 [medline] PHST- 2024/06/10 23:14 [entrez] AID - 10.1007/s00586-024-08359-7 [pii] AID - 10.1007/s00586-024-08359-7 [doi] PST - ppublish SO - Eur Spine J. 2026 Feb;35(2):644-653. doi: 10.1007/s00586-024-08359-7. Epub 2024 Jun 10. PMID- 38858062 OWN - NLM STAT- MEDLINE DCOM- 20240610 LR - 20260826 IS - 1879-1247 (Electronic) IS - 0022-4375 (Linking) VI - 89 DP - 2024 Jun TI - Perceptions of vulnerable roadway users on autonomous vehicle regulations. PG - 41-55 LID - S0022-4375(24)00019-7 [pii] LID - 10.1016/j.jsr.2024.02.005 [doi] AB - INTRODUCTION: Development and implementation of autonomous vehicle (AV) related regulations are necessary to ensure safe AV deployment and wide acceptance among all roadway users. Assessment of vulnerable roadway users' perceptions on AV regulations could inform policymakers the development of appropriate AV regulations that facilitate the safety of diverse users in a multimodal transportation system. METHOD: This research evaluated pedestrians' and bicyclists' perceptions on six AV regulations (i.e., capping AV speed limit, operating AV in manual mode in the sensitive areas, having both pilot and co-pilot while operating AVs, and three data-sharing regulations). In addition, pedestrians' and bicyclists' perceptions of testing AVs in public streets were evaluated. Statistical testing and modeling techniques were applied to accomplish the research objectives. RESULTS: Compared to the other AV regulations assessed in this research, strong support for AV-related data sharing regulations was identified. Older respondents showed higher approval of AV testing on public roadways and less support for regulating AVs. AV technology familiarity and safe road sharing perceptions with AVs resulted in lower support for AV regulations. CONCLUSIONS: Policymakers and AV technology developers could develop effective educational tools/resources to inform pedestrians and bicyclists about AV technology reliability and soften their stance, especially on AV regulations, which could delay technology development. PRACTICAL APPLICATIONS: The findings of this research could be used to develop informed AV regulations and develop policies that could improve pedestrians' and bicyclists' attitudes/perceptions on regulating AVs and promoting AV technology deployments. CI - Copyright (c) 2024 National Safety Council and Elsevier Ltd. All rights reserved. FAU - Rahman, Md Tawhidur AU - Rahman MT AD - Technology/ITS Engineer, AECOM, 7720 N 16th Street, Phoenix, AZ 85020, USA. Electronic address: mdtawhidur.rahman@aecom.com. FAU - Dey, Kakan AU - Dey K AD - Department of Civil and Environmental Engineering, Michigan State University, 1460 Middlevale Rd, East Lansing, MI 48823, USA. Electronic address: kakan@msu.edu. FAU - Ashraf, Md Tanvir AU - Ashraf MT AD - Department of Civil and Environmental Engineering, Michigan State University, 1460 Middlevale Rd, East Lansing, MI 48823, USA. Electronic address: ashrafmd@msu.edu. LA - eng PT - Journal Article DEP - 20240223 PL - United States TA - J Safety Res JT - Journal of safety research JID - 1264241 SB - IM MH - Humans MH - Male MH - Adult MH - Female MH - *Bicycling/legislation & jurisprudence MH - Middle Aged MH - *Pedestrians/psychology MH - Young Adult MH - Accidents, Traffic/prevention & control MH - Adolescent MH - Walking MH - Perception MH - Aged MH - Safety/legislation & jurisprudence MH - Surveys and Questionnaires MH - Automobiles/legislation & jurisprudence OTO - NOTNLM OT - AV speed limit OT - Data-sharing OT - Regulations OT - autonomous vehicle (AV) COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/06/11 00:42 MHDA- 2024/06/11 00:43 CRDT- 2024/06/10 21:06 PHST- 2022/11/09 00:00 [received] PHST- 2023/11/30 00:00 [revised] PHST- 2024/02/08 00:00 [accepted] PHST- 2024/06/11 00:43 [medline] PHST- 2024/06/11 00:42 [pubmed] PHST- 2024/06/10 21:06 [entrez] AID - S0022-4375(24)00019-7 [pii] AID - 10.1016/j.jsr.2024.02.005 [doi] PST - ppublish SO - J Safety Res. 2024 Jun;89:41-55. doi: 10.1016/j.jsr.2024.02.005. Epub 2024 Feb 23. PMID- 38857870 OWN - NLM STAT- MEDLINE DCOM- 20240910 LR - 20250501 IS - 1878-8769 (Electronic) IS - 1878-8750 (Linking) VI - 189 DP - 2024 Sep TI - Association of Body Mass Index and Central Obesity with Spinopelvic Alignment Parameters in a Chinese Population: A Prospective Study. PG - e153-e161 LID - S1878-8750(24)00952-5 [pii] LID - 10.1016/j.wneu.2024.06.005 [doi] AB - OBJECTIVE: The purpose of this study was to explore the impact of central obesity on spinal sagittal balance in adults aged 18 and older by examining correlations between waist circumference (WC) and abdominal circumference (AC) and spinopelvic alignment parameters. METHODS: This prospective cohort study included 350 adults aged 18 and older. Participants underwent whole-body biplanar radiography using the EOS imaging system. Spinal and pelvic parameters were measured and correlated with body mass index, WC, and AC. Statistical analyses included one-way analysis of variance, Wilcoxon rank-sum tests for data with nonhomogeneous variances, and chi-squared tests for categorical data. Intra-rater and inter-rater reliability were assessed using intraclass correlation coefficients, with subsequent analyses to explore correlations between body measurements and spinal parameters. RESULTS: The study found significant correlations between increased WC and AC and changes in spinopelvic parameters. However, obesity did not uniformly influence all sagittal alignment parameters. Significant variations in spinal measurements indicate that central obesity plays a role in altering spinal stability and alignment. CONCLUSIONS: The findings highlight the impact of central obesity on spinal alignment and emphasize the importance of considering central obesity in clinical assessments of spinal pathologies. Further research is essential to better understand the relationship between obesity, spinal sagittal balance, and related health conditions. CI - Copyright (c) 2024 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Qi, Hao AU - Qi H AD - Department of Spine Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Zhao, Zenghui AU - Zhao Z AD - Department of Spine Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Zu, Feiyu AU - Zu F AD - Department of Spine Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Wang, Chenxi AU - Wang C AD - Department of Spine Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Wang, Chenchen AU - Wang C AD - Department of Spine Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Zhang, Zuzhuo AU - Zhang Z AD - Department of Radiology, The Third Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Tian, Xiaonan AU - Tian X AD - CT/MRI Department of the Third Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Su, Dan AU - Su D AD - Department of Spine Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Wang, Zhaoxuan AU - Wang Z AD - Department of Spine Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Xue, Rui AU - Xue R AD - Department of Spine Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Hou, Zhiyong AU - Hou Z AD - Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, China; Department of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Chen, Wei AU - Chen W AD - Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, China; Department of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Zhang, Di AU - Zhang D AD - Department of Spine Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China. Electronic address: 38300320@hebmu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240608 PL - United States TA - World Neurosurg JT - World neurosurgery JID - 101528275 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - *Body Mass Index MH - China/epidemiology MH - Cohort Studies MH - East Asian People MH - *Obesity, Abdominal/diagnostic imaging MH - Pelvis/diagnostic imaging/anatomy & histology MH - Prospective Studies MH - Spine/diagnostic imaging MH - *Waist Circumference OTO - NOTNLM OT - Abdominal circumference OT - Central obesity OT - Obesity management OT - Spinal sagittal balance OT - Spinopelvic parameters OT - Waist circumference EDAT- 2024/06/11 00:42 MHDA- 2024/09/10 06:43 CRDT- 2024/06/10 19:27 PHST- 2024/05/14 00:00 [received] PHST- 2024/05/31 00:00 [revised] PHST- 2024/06/01 00:00 [accepted] PHST- 2024/09/10 06:43 [medline] PHST- 2024/06/11 00:42 [pubmed] PHST- 2024/06/10 19:27 [entrez] AID - S1878-8750(24)00952-5 [pii] AID - 10.1016/j.wneu.2024.06.005 [doi] PST - ppublish SO - World Neurosurg. 2024 Sep;189:e153-e161. doi: 10.1016/j.wneu.2024.06.005. Epub 2024 Jun 8. PMID- 38857694 OWN - NLM STAT- MEDLINE DCOM- 20240803 LR - 20260429 IS - 1938-3207 (Electronic) IS - 0002-9165 (Linking) VI - 120 IP - 2 DP - 2024 Aug TI - Association of adverse childhood experiences with dietary patterns of school-age children: evidence from the birth cohort Generation XXI. PG - 328-335 LID - S0002-9165(24)00525-2 [pii] LID - 10.1016/j.ajcnut.2024.06.003 [doi] AB - BACKGROUND: Adverse Childhood Experiences (ACEs) have been associated with health-risk behaviors and several chronic diseases in adulthood. However, the relationship between exposure to ACEs and dietary patterns at school age is unknown. OBJECTIVES: To investigate the association between ACEs and dietary patterns of 10-year-olds. METHODS: The study included 5034 children from the Generation XXI cohort, recruited in 2005/2006 in Porto, Portugal. ACEs were assessed through a self-administered questionnaire covering the first 10 years (y) of life, quantified and grouped into 5 dimensions: "abuse," "school problems," "death/severe disease," "life changes," and "household dysfunction." Dietary patterns were identified by latent class analysis using data collected with a validated food frequency questionnaire. Five dietary patterns were studied: "low consumption," "energy-dense foods," "snacking," "intermediate consumption," and "healthier" (used as reference). Multinomial regression analyses were conducted, adjusted for the child's sex, household income, family structure, and mother's age [odds ratio (OR) and 99% confidence intervals (CIs)]. RESULTS: Most children were exposed to >/=1 ACE (96%), and approximately 27% had reported 6 or more ACEs throughout life. Those reporting 4-5 and >/=6 ACEs were more likely to follow the "Energy-dense foods" dietary pattern compared with those with no ACEs (OR: 2.41; 99% CI: 1.00, 5.77 and OR: 2.65; 99% CI: 1.10, 6.39, respectively). Children exposed to "abuse" in the first 10 y showed 28% higher odds of following the "low consumption" dietary pattern when compared to children with no reported ACEs and using the "healthier" dietary pattern as a reference (OR: 1.28; 99% CI: 1.00, 1.63). CONCLUSIONS: Exposure to ACEs was associated with less healthy dietary patterns in school-aged children. Results suggest a cumulative effect of the adverse experiences resulting in a dietary pattern higher in energy-dense foods. Children with ACEs reported under the dimension of "abuse" seemed to have reduced food consumption. CI - Copyright (c) 2024 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Ferreira, Pedro AU - Ferreira P AD - EPIUnit, Instituto de Saude Publica, Universidade do Porto (Epidemiology Research Unit, Institute of Public Health, University of Porto), Porto, Portugal; Laboratory for Integrative and Translational Research in Population Health, Porto, Portugal. FAU - Fraga, Silvia AU - Fraga S AD - EPIUnit, Instituto de Saude Publica, Universidade do Porto (Epidemiology Research Unit, Institute of Public Health, University of Porto), Porto, Portugal; Laboratory for Integrative and Translational Research in Population Health, Porto, Portugal; Department of Public Health and Forensic Sciences and Medical Education, Faculty of Medicine, University of Porto, Porto, Portugal. FAU - Oliveira, Andreia AU - Oliveira A AD - EPIUnit, Instituto de Saude Publica, Universidade do Porto (Epidemiology Research Unit, Institute of Public Health, University of Porto), Porto, Portugal; Laboratory for Integrative and Translational Research in Population Health, Porto, Portugal; Department of Public Health and Forensic Sciences and Medical Education, Faculty of Medicine, University of Porto, Porto, Portugal. Electronic address: acmatos@ispup.up.pt. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240608 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Child MH - Female MH - Humans MH - Male MH - *Adverse Childhood Experiences/statistics & numerical data MH - Birth Cohort MH - Cohort Studies MH - Portugal MH - Surveys and Questionnaires OTO - NOTNLM OT - adversity OT - childhood OT - cohort studies OT - diet OT - feeding behavior COIS- Conflict of interest The authors report no conflict of interest. EDAT- 2024/06/11 00:42 MHDA- 2024/08/04 13:44 CRDT- 2024/06/10 19:23 PHST- 2024/01/18 00:00 [received] PHST- 2024/06/03 00:00 [revised] PHST- 2024/06/06 00:00 [accepted] PHST- 2024/08/04 13:44 [medline] PHST- 2024/06/11 00:42 [pubmed] PHST- 2024/06/10 19:23 [entrez] AID - S0002-9165(24)00525-2 [pii] AID - 10.1016/j.ajcnut.2024.06.003 [doi] PST - ppublish SO - Am J Clin Nutr. 2024 Aug;120(2):328-335. doi: 10.1016/j.ajcnut.2024.06.003. Epub 2024 Jun 8. PMID- 38857314 OWN - NLM STAT- MEDLINE DCOM- 20240829 LR - 20250528 IS - 1536-3724 (Electronic) IS - 1050-642X (Linking) VI - 34 IP - 5 DP - 2024 Sep 1 TI - A New Measuring Approach in Assessing Hamstring Flexibility: Reliability, Validity, and Applicability of Isolated Hamstring Flexibility Test. PG - 430-435 LID - 10.1097/JSM.0000000000001235 [doi] AB - OBJECTIVE: This study was planned to determine the reliability, validity, and applicability of the isolated hamstring flexibility test (IHFT). DESIGN: A cohort study (diagnosis); level of evidence, 2. SETTING: It was performed in the research and application laboratory. PARTICIPANTS: Seventy-five individuals aged 18 to 25 years, selected through simple probability random sampling, with a normal Beighton Horan and Joint Mobility Index scores, and who volunteered to participate, were included for evaluation. INTERVENTIONS: On then first and third days, participants underwent muscle strength, sit-and-reach test, active knee extension test, IHFT for validity and reliability. Stretching exercises were prescribed as a home program for 31 patients with limited knee extension, and measurements were repeated at the end of the eighth week. MAIN OUTCOME MEASURES: Sit-and-reach test, active knee extension test, IHFT. RESULTS: The test-retest reliability was high (intraclass correlation coefficient, 0.993). Our test demonstrated validity when compared in terms of flexibility gained. A significant difference was found between pre-post stretching exercise training in all 3 tests ( P < 0.05). CONCLUSION: It was observed that the IHFT is reliable and applicable in determining hamstring flexibility. Given the absence of another test specifically measuring hamstring flexibility in isolation, its indirect validity was established through analysis with other tests using the gold standard for assessing gains in hamstring flexibility. CI - Copyright (c) 2024 Wolters Kluwer Health, Inc. All rights reserved. FAU - Talu, Yasin AU - Talu Y AD - Malatya Training and Research Hospital, Malatya, Turkiye. FAU - Tuncer, Aysenur AU - Tuncer A AD - Physiotherapy and Rehabilitation Department, Faculty of Health Sciences, Hasan Kalyoncu University, Gaziantep, Turkiye; and. FAU - Talu, Burcu AU - Talu B AUID- ORCID: 0000-0002-5623-8291 AD - Physiotherapy and Rehabilitation Department, Faculty of Health Sciences, Inonu University, Malatya, Turkiye. LA - eng PT - Journal Article PT - Validation Study DEP - 20240611 PL - United States TA - Clin J Sport Med JT - Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine JID - 9103300 SB - IM MH - Humans MH - Adult MH - Male MH - Adolescent MH - *Hamstring Muscles/physiology MH - Reproducibility of Results MH - Female MH - Young Adult MH - *Range of Motion, Articular MH - Muscle Stretching Exercises MH - Exercise Test/methods MH - Cohort Studies MH - Muscle Strength/physiology COIS- The authors report no conflicts of interest. EDAT- 2024/06/10 18:42 MHDA- 2024/08/31 09:51 CRDT- 2024/06/10 14:02 PHST- 2024/05/15 00:00 [accepted] PHST- 2024/08/31 09:51 [medline] PHST- 2024/06/10 18:42 [pubmed] PHST- 2024/06/10 14:02 [entrez] AID - 00042752-202409000-00006 [pii] AID - 10.1097/JSM.0000000000001235 [doi] PST - ppublish SO - Clin J Sport Med. 2024 Sep 1;34(5):430-435. doi: 10.1097/JSM.0000000000001235. Epub 2024 Jun 11. PMID- 38853175 OWN - NLM STAT- MEDLINE DCOM- 20240609 LR - 20240612 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Jun 9 TI - Association between a western diet and asthma among children and adolescents. PG - 13240 LID - 10.1038/s41598-024-64008-5 [doi] LID - 13240 AB - Several risk factors including environmental exposures, socioeconomic status, and dietary factors including dietary patterns have been considered for childhood Asthma. The present study tried to examine the association between a western-style pattern and the likelihood of asthma and its symptoms in Yazd, Iran. In the present cross-sectional study, dietary intakes of elementary and high-school children were obtained through a validated GAN questionnaire. The GAN questionnaire, derived from the ISAAC questionnaire was used to assess the symptoms of allergic diseases and their related risk factors. A western dietary pattern score considered 9 food groups including chicken eggs, margarine, butter, sugar, fast foods, soft drinks, snacks, sauce, and chocolate. In total 7667 children aged 10.9 +/- 3.35 years were included in the current investigation. Boys with higher adherence to western dietary pattern had a higher risk of wheezing in the past 12 months (OR 1.37, 5% CI 1.01-1.87, P = 0.04) and this association was also observed in the whole population (OR 1.30, 5% CI 1.05-1.60, P = 0.01). However, after adjustment for confounders this relation did not remain significant in boys. Our results support the hypothesis that a western dietary pattern is associated with an increased risk of wheezing in the past 12 months in children with asthma. Future prospective studies are needed to confirm this finding. CI - (c) 2024. The Author(s). FAU - Emrani, Arezoo Sadat AU - Emrani AS AD - Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. FAU - Sasanfar, Bahareh AU - Sasanfar B AD - Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran. AD - Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. FAU - Jowshan, Mohammad-Reza AU - Jowshan MR AD - Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. AD - Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. FAU - Behniafard, Nasrin AU - Behniafard N AD - Children Growth Disorder Research Center, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Ebne sina boulevard, Yazd, Iran. AD - Department of Allergy and Clinical Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. FAU - Nafei, Zahra AU - Nafei Z AD - Children Growth Disorder Research Center, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Ebne sina boulevard, Yazd, Iran. Nafeiy@yahoo.com. FAU - Salehi-Abargouei, Amin AU - Salehi-Abargouei A AD - Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Yazd Cardiovascular Research Center, Non-Communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. LA - eng PT - Journal Article DEP - 20240609 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Asthma/epidemiology/etiology MH - Male MH - Child MH - Adolescent MH - Female MH - *Diet, Western/adverse effects MH - Cross-Sectional Studies MH - Risk Factors MH - Iran/epidemiology MH - Surveys and Questionnaires MH - Respiratory Sounds/etiology PMC - PMC11162998 OTO - NOTNLM OT - Asthma OT - Children OT - Cross sectional OT - Western diet OT - Western pattern COIS- The authors declare no competing interests. EDAT- 2024/06/10 00:42 MHDA- 2024/06/10 00:43 PMCR- 2024/06/09 CRDT- 2024/06/09 23:06 PHST- 2024/04/08 00:00 [received] PHST- 2024/06/04 00:00 [accepted] PHST- 2024/06/10 00:43 [medline] PHST- 2024/06/10 00:42 [pubmed] PHST- 2024/06/09 23:06 [entrez] PHST- 2024/06/09 00:00 [pmc-release] AID - 10.1038/s41598-024-64008-5 [pii] AID - 64008 [pii] AID - 10.1038/s41598-024-64008-5 [doi] PST - epublish SO - Sci Rep. 2024 Jun 9;14(1):13240. doi: 10.1038/s41598-024-64008-5. PMID- 38852855 OWN - NLM STAT- MEDLINE DCOM- 20240803 LR - 20260429 IS - 1938-3207 (Electronic) IS - 0002-9165 (Linking) VI - 120 IP - 2 DP - 2024 Aug TI - Development of a national database for dietary glycemic index and load for nutritional epidemiologic studies in the United States. PG - 380-388 LID - S0002-9165(24)00522-7 [pii] LID - 10.1016/j.ajcnut.2024.06.001 [doi] AB - BACKGROUND: The quality of carbohydrate intake, as measured by the glycemic index (GI), has not been evaluated nationally over the past 2 decades in the United States. OBJECTIVES: We aimed to develop a comprehensive and nationally representative dietary GI and glycemic load (GL) database from 1999 to 2018 National Health and Nutrition Examination Survey (NHANES) and to examine GI and GL time trends and subpopulation differences. METHODS: We used an artificial intelligence (AI)-enabled model to match GI values from 2 GI databases to food codes from United States Department of Agriculture, which were manually validated. We examined nationally representative distributions of dietary GI and GL from 1999 to 2018 using the multistage, clustered sampling design of NHANES. RESULTS: Assigned GI values covered 99.9% of total carbohydrate intake. The initial AI accuracy was 75.0%, with 31.3% retained after manual curation guided by substantive domain expertise. A total of 7976 unique food codes were matched to GI values, of which soft drinks and white bread were top contributors to dietary GI and GL. Of the 49,205 NHANES adult participants, the mean dietary GI was 55.7 (95% confidence interval [CI]: 55.5, 55.8) and energy-adjusted dietary GL was 133.0 (95% CI: 132.3, 133.8). From 1999 to 2018, dietary GI and GL decreased by 4.6% and 13.8%, respectively. Dietary GL was higher among females (134.6; 95% CI: 133.8, 135.5) than among males (131.3; 95% CI: 130.3, 132.3), those with /=college degree (126.5; 95% CI: 125.3, 127.7), and those living under the poverty level (140.9; 95% CI: 139.6, 142.1) than among those above the poverty level. Differences in race were observed (Black adults, 139.4; 95% CI: 138.2, 140.7; White adults, 131.6; 95% CI: 130.5, 132.6). CONCLUSIONS: The national GI and GL database facilitates large-scale and high-quality surveillance or cohort studies of diet and health outcomes in the United States. CI - Copyright (c) 2024 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Della Corte, Karen A AU - Della Corte KA AD - Department of Nutrition, Dietetics, and Food Science, Brigham Young University, Provo, UT, United States. Electronic address: karen_dellacorte@byu.edu. FAU - Della Corte, Dennis AU - Della Corte D AD - Department of Physics and Astronomy, Brigham Young University, Provo, UT, United States. FAU - Titensor, Sean AU - Titensor S AD - Department of Nutrition, Dietetics, and Food Science, Brigham Young University, Provo, UT, United States; Department of Physics and Astronomy, Brigham Young University, Provo, UT, United States. FAU - Yang, Bo AU - Yang B AD - Departments of Epidemiology, Medicine, and Surgery, Brown University, Providence, RI, United States. FAU - Liu, Simin AU - Liu S AD - Departments of Epidemiology, Medicine, and Surgery, Brown University, Providence, RI, United States. Electronic address: simin_liu@brown.edu. LA - eng PT - Journal Article DEP - 20240607 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 RN - 0 (Dietary Carbohydrates) SB - IM MH - Humans MH - *Glycemic Index MH - United States MH - *Glycemic Load MH - Female MH - Male MH - *Nutrition Surveys MH - *Databases, Factual MH - Adult MH - Middle Aged MH - *Diet MH - Dietary Carbohydrates MH - Young Adult MH - Epidemiologic Studies MH - Aged MH - Adolescent OTO - NOTNLM OT - National Health and Nutrition Examination Survey OT - artificial intelligence OT - carbohydrate quality OT - glycemic index assignment OT - glycemic load OT - national trends EDAT- 2024/06/10 00:42 MHDA- 2024/08/04 13:44 CRDT- 2024/06/09 19:28 PHST- 2023/12/29 00:00 [received] PHST- 2024/05/29 00:00 [revised] PHST- 2024/06/04 00:00 [accepted] PHST- 2024/08/04 13:44 [medline] PHST- 2024/06/10 00:42 [pubmed] PHST- 2024/06/09 19:28 [entrez] AID - S0002-9165(24)00522-7 [pii] AID - 10.1016/j.ajcnut.2024.06.001 [doi] PST - ppublish SO - Am J Clin Nutr. 2024 Aug;120(2):380-388. doi: 10.1016/j.ajcnut.2024.06.001. Epub 2024 Jun 7. PMID- 38851219 OWN - NLM STAT- MEDLINE DCOM- 20240608 LR - 20240612 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 8 IP - 1 DP - 2024 Jun 8 TI - Dermatological changes in a prospective cohort of acutely ill, hospitalised Malawian children, stratified according to nutritional status. LID - 10.1136/bmjpo-2023-002289 [doi] LID - e002289 AB - RATIONALE: Since the first documentation of skin changes in malnutrition in the early 18th century, various hair and skin changes have been reported in severely malnourished children globally. We aimed to describe the frequency and types of skin conditions in children admitted with acute illness to Queen Elizabeth Central Hospital, Blantyre, Malawi across a spectrum of nutritional status and validate an existing skin assessment tool. METHODS: Children between 1 week and 23 months of age with acute illness were enrolled and stratified by anthropometry. Standardised photographs were taken, and three dermatologists assessed skin changes and scored each child according to the SCORDoK tool. RESULTS: Among 103 children, median age of 12 months, 31 (30%) had severe wasting, 11 (11%) kwashiorkor (nutritional oedema), 20 (19%) had moderate wasting, 41 (40%) had no nutritional wasting and 18 (17%) a positive HIV antibody test. Six (5.8%) of the included patients died. 51 (50%) of children presented with at least one skin change. Pigmentary changes were the most common, observed in 35 (34%), with hair loss and bullae, erosions and desquamation the second most prevalent skin condition. Common diagnoses were congenital dermal melanocytosis, diaper dermatitis, eczema and postinflammatory hyperpigmentation. Severe skin changes like flaky paint dermatosis were rarely identified. Inter-rater variability calculations showed only fair agreement (overall Fleiss' kappa 0.25) while intrarater variability had a fair-moderate agreement (Cohen's kappa score of 0.47-0.58). DISCUSSION: Skin changes in hospitalised children with an acute illness and stratified according to nutritional status were not as prevalent as historically reported. Dermatological assessment by means of the SKORDoK tool using photographs is less reliable than expected. CI - (c) Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ. FAU - van den Brink, Deborah AU - van den Brink D AUID- ORCID: 0000-0002-0458-0669 AD - Amsterdam Centre for Global Child Health & Emma Children's Hospital, Pediatrics, Amsterdam UMC, Locatie AMC, Amsterdam, The Netherlands d.vandenbrink@alumni.ubc.ca. FAU - Mponda, Kelvin AU - Mponda K AD - Department of Dermatology, Queen Elizabeth Central Hospital, Blantyre, Southern Region, Malawi. FAU - Thompson, Debbie AU - Thompson D AUID- ORCID: 0000-0001-6781-7646 AD - Caribbean Institute for Health Research, University of the West Indies, Kingston, Jamaica. FAU - van Hees, Colette AU - van Hees C AD - Department of Dermatology, Erasmus Medical Center, Rotterdam, The Netherlands. FAU - Ngong'a, Fletchter AU - Ngong'a F AD - Department of Paediatrics and Child Health, Kamuzu University of Health Sciences, Blantyre, Southern Region, Malawi. FAU - Segula, Emma AU - Segula E AD - Department of Paediatrics and Child Health, Kamuzu University of Health Sciences, Blantyre, Southern Region, Malawi. FAU - Mbale, Emmie AU - Mbale E AD - Department of Paediatrics and Child Health, Kamuzu University of Health Sciences, Blantyre, Southern Region, Malawi. FAU - Boele van Hensbroek, Michael AU - Boele van Hensbroek M AD - Amsterdam Centre for Global Child Health & Emma Children's Hospital, Pediatrics, Amsterdam UMC, Locatie AMC, Amsterdam, The Netherlands. FAU - Bandsma, Robert H J AU - Bandsma RHJ AD - Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada. AD - Childhood Acute Illness Network, Nairobi, Kenya. FAU - Walson, Judd L AU - Walson JL AUID- ORCID: 0000-0003-4836-720X AD - Childhood Acute Illness Network, Nairobi, Kenya. AD - Departments of Global Health, Epidemiology, Infectious Disease, University of Washington, Seattle, Washington, USA. FAU - Brals, Daniella AU - Brals D AD - Department of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam, Netherlands. FAU - Berkely, James AU - Berkely J AD - Childhood Acute Illness Network, Nairobi, Kenya. AD - KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. AD - Centre for Tropcial Medicine & Global Health, Oxford University, Oxford, UK. FAU - Voskuijl, Wieger AU - Voskuijl W AD - Amsterdam Centre for Global Child Health & Emma Children's Hospital, Pediatrics, Amsterdam UMC, Locatie AMC, Amsterdam, The Netherlands. AD - Department of Paediatrics and Child Health, Kamuzu University of Health Sciences, Blantyre, Southern Region, Malawi. AD - Childhood Acute Illness Network, Nairobi, Kenya. LA - eng PT - Journal Article DEP - 20240608 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Infant MH - Malawi/epidemiology MH - *Nutritional Status MH - Male MH - Female MH - Prospective Studies MH - Acute Disease MH - Infant, Newborn MH - Skin Diseases/epidemiology/pathology/diagnosis MH - Hospitalization/statistics & numerical data MH - Kwashiorkor/epidemiology/diagnosis MH - Skin/pathology PMC - PMC11163641 OTO - NOTNLM OT - Data Collection OT - Dermatology OT - Epidemiology COIS- Competing interests: None declared. EDAT- 2024/06/09 09:42 MHDA- 2024/06/09 09:43 PMCR- 2024/06/08 CRDT- 2024/06/08 20:42 PHST- 2023/11/05 00:00 [received] PHST- 2024/05/16 00:00 [accepted] PHST- 2024/06/09 09:43 [medline] PHST- 2024/06/09 09:42 [pubmed] PHST- 2024/06/08 20:42 [entrez] PHST- 2024/06/08 00:00 [pmc-release] AID - 10.1136/bmjpo-2023-002289 [pii] AID - bmjpo-2023-002289 [pii] AID - 10.1136/bmjpo-2023-002289 [doi] PST - epublish SO - BMJ Paediatr Open. 2024 Jun 8;8(1):e002289. doi: 10.1136/bmjpo-2023-002289. PMID- 38849953 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240610 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 12 IP - 1 DP - 2024 Jun 7 TI - Avoidant restrictive food intake disorder: recent advances in neurobiology and treatment. PG - 74 LID - 10.1186/s40337-024-01021-z [doi] LID - 74 AB - Avoidant restrictive food intake disorder (ARFID) is an eating disorder characterized by persistent insufficient nutritional and/or energy intake. ARFID, before referred to as "selective eating disorder", was introduced recently in the DSM-5 as a replacement for and expansion of the previous diagnosis. Individuals with ARFID may limit food variety and intake due to avoidance based on the sensory characteristics of the food or related to any adverse consequences of eating without the intention of losing weight and concerns of body image. The limited understanding of avoidant and restrictive eating poses challenges to effective treatment and management, impacting directly on the growth and development of children and adolescents. The ARFID neurobiological concept has not yet been clearly defined to clinical practice for nutritionists, thereby hindering screening and impeding the development of treatment recommendations. This narrative review provide useful practical information to consult the pathophysiology, the neurobiology, the clinical features, the assessment and the treatment for healthcare professionals seeking to enhance their clinical knowledge and management of this disorder. CI - (c) 2024. The Author(s). FAU - Fonseca, Natasha K O AU - Fonseca NKO AUID- ORCID: 0000-0003-4661-5740 AD - Graduate Program in Psychiatry and Behavioral Sciences, Universidade Federal do Rio Grande do Sul (UFRGS), Ramiro Barcelos, 2400, Porto Alegre, RS, 90035-003, Brazil. natashakof@gmail.com. FAU - Curtarelli, Vitoria D AU - Curtarelli VD AD - Universidade Federal de Santa Catarina (UFSC), Florianopolis, SC, Brazil. FAU - Bertoletti, Juliana AU - Bertoletti J AD - , Florianopolis, SC, Brazil. FAU - Azevedo, Karla AU - Azevedo K AD - Universidade Federal de Santa Catarina (UFSC), Florianopolis, SC, Brazil. AD - Translational Nutritional Neuroscience Working Group, Universidade Federal de Santa Catarina (UFSC), Florianopolis, SC, Brazil. FAU - Cardinal, Tiago M AU - Cardinal TM AD - Laboratory of Neuroscience and Eating Behavior, Universidade Federal de Santa Catarina (UFSC), Florianopolis, SC, Brazil. FAU - Moreira, Julia D AU - Moreira JD AUID- ORCID: 0000-0002-2256-7222 AD - Department of Nutrition, Health Sciences Center, Universidade Federal de Santa Catarina (UFSC), Florianopolis, SC, Brazil. AD - Translational Nutritional Neuroscience Working Group, Universidade Federal de Santa Catarina (UFSC), Florianopolis, SC, Brazil. FAU - Antunes, Luciana C AU - Antunes LC AUID- ORCID: 0000-0002-0106-0721 AD - Laboratory of Neuroscience and Eating Behavior, Universidade Federal de Santa Catarina (UFSC), Florianopolis, SC, Brazil. AD - Department of Nutrition, Health Sciences Center, Universidade Federal de Santa Catarina (UFSC), Florianopolis, SC, Brazil. AD - Translational Nutritional Neuroscience Working Group, Universidade Federal de Santa Catarina (UFSC), Florianopolis, SC, Brazil. LA - eng PT - Journal Article PT - Review DEP - 20240607 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC11157884 OAB - Avoidant restrictive food intake disorder (ARFID) is an eating disorder characterized by persistent insufficient nutritional and/or energy intake. Individuals with ARFID exhibit limited food intake and variety, often due to a lack in eating, without the primary goal of weight loss. The limited understanding of avoidant and restrictive eating poses challenges in terms of effective treatment and management, which directly impacts the growth and development of children and adolescents, as well as their nutrition and psychosocial well-being. ARFID is a relatively recent diagnostic classification, representing a burgeoning field of study. The identification of diagnostic criteria and the pursuit of new knowledge in this area have only recently begun. Consequently, assessment tools and treatment strategies are still in the process of development and validation. This narrative review explored the neurobiological perspective of ARFID using the three-dimensional model, examined its etiology and risk factors, evaluated clinical screening and evaluation tools, discussed common clinical complications, and presented different types of nutritional, behavioural, and pharmacological interventions used in ARFID treatment. OABL- eng OTO - NOTNLM OT - Avoidant restrictive food intake disorder OT - Eating disorders OT - Restrictive eating OT - Selective eating COIS- The authors have no conflicts of interest to declare. All authors consent to release for publication all details and figures in this manuscript. The authors declare no competing interests. EDAT- 2024/06/08 10:43 MHDA- 2024/06/08 10:44 PMCR- 2024/06/07 CRDT- 2024/06/07 23:44 PHST- 2023/11/03 00:00 [received] PHST- 2024/05/14 00:00 [accepted] PHST- 2024/06/08 10:44 [medline] PHST- 2024/06/08 10:43 [pubmed] PHST- 2024/06/07 23:44 [entrez] PHST- 2024/06/07 00:00 [pmc-release] AID - 10.1186/s40337-024-01021-z [pii] AID - 1021 [pii] AID - 10.1186/s40337-024-01021-z [doi] PST - epublish SO - J Eat Disord. 2024 Jun 7;12(1):74. doi: 10.1186/s40337-024-01021-z. PMID- 38848953 OWN - NLM STAT- MEDLINE DCOM- 20240929 LR - 20240929 IS - 1556-5653 (Electronic) IS - 0015-0282 (Linking) VI - 122 IP - 4 DP - 2024 Oct TI - Maternal stress in pregnancy and pubertal timing in girls and boys: a cohort study. PG - 715-726 LID - S0015-0282(24)00520-X [pii] LID - 10.1016/j.fertnstert.2024.06.001 [doi] AB - OBJECTIVE: To investigate whether maternal stress in pregnancy is associated with pubertal timing in girls and boys and to explore potential mediation by childhood body mass index (BMI) and childhood psychosocial stress. DESIGN: Cohort study. SETTING: Not applicable. PATIENTS: In total, 14,702 girls and boys from the Puberty Cohort, nested within the Danish National Birth Cohort. INTERVENTION: Maternal stress was obtained from a computer-assisted telephone interview in gestational weeks 30-32 as maternal life stress and emotional distress in pregnancy using questions on the basis of validated screening tools. Maternal life stress and emotional distress in pregnancy were analyzed separately and in an interaction analysis. MAIN OUTCOME MEASURES: Pubertal timing was measured half-yearly from age 11 years and throughout pubertal development and assessed as Tanner stages 1-5 (breast and pubic hair development in girls and genital and pubic hair development in boys), menarche in girls, voice break and first ejaculation in boys, and occurrence of acne and axillary hair in both girls and boys. A combined estimate for overall pubertal timing was derived using Huber-White robust variance estimation. Mean differences in age at attaining the pubertal milestones according to prenatal exposure to no (reference), low-, moderate-, or high-maternal stress in pregnancy were estimated using a multivariable censored regression model. Potential mediation by childhood BMI and childhood psychosocial stress was investigated in separate models. RESULTS: After adjustment for potential confounding factors, prenatal exposure to high-maternal life stress (combined estimate: -1.8 months [95% CI, -2.7 to -0.8] and -0.9 months [95% CI, -1.8 to 0.0]), high maternal emotional distress (combined estimate: -1.5 months [95% CI, -2.5 to -0.5] and -1.7 months [95% CI, -2.8 to -0.7]), and both high-maternal life stress and emotional distress (combined estimate: -2.8 months [95% CI, -4.2, to -1.4] and -1.7 months [95% CI, -3.1 to -0.2]) were associated with earlier pubertal timing in girls and boys, respectively. The associations were not mediated by childhood BMI or childhood psychosocial stress. CONCLUSIONS: Prenatal exposure to maternal stress in pregnancy was associated with earlier pubertal timing in girls and boys in a dose-dependent manner. The associations were not mediated by childhood BMI or childhood psychosocial stress. CI - Copyright (c) 2024 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Gaml-Sorensen, Anne AU - Gaml-Sorensen A AD - Research Unit for Epidemiology, Department of Public Health, Aarhus University, Aarhus C, Denmark. Electronic address: ags@ph.au.dk. FAU - Brix, Nis AU - Brix N AD - Research Unit for Epidemiology, Department of Public Health, Aarhus University, Aarhus C, Denmark; Department of Clinical Genetics, Aarhus University Hospital, Aarhus N, Denmark. FAU - Henriksen, Tine B AU - Henriksen TB AD - Perinatal Epidemiology Research Unit, Department of Clinical Medicine, Aarhus N, Aarhus University; Department of Paediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus N, Denmark. FAU - Ramlau-Hansen, Cecilia H AU - Ramlau-Hansen CH AD - Research Unit for Epidemiology, Department of Public Health, Aarhus University, Aarhus C, Denmark. LA - eng PT - Journal Article DEP - 20240605 PL - United States TA - Fertil Steril JT - Fertility and sterility JID - 0372772 SB - IM MH - Humans MH - Female MH - Male MH - Pregnancy MH - *Prenatal Exposure Delayed Effects/psychology/physiopathology MH - *Stress, Psychological/epidemiology/psychology/physiopathology MH - Child MH - *Puberty/psychology/physiology MH - Denmark/epidemiology MH - Adolescent MH - Body Mass Index MH - Time Factors MH - Age Factors MH - Risk Factors MH - Sexual Maturation/physiology MH - Cohort Studies MH - Adult OTO - NOTNLM OT - Prenatal exposure OT - delayed effects OT - emotional distress OT - life stress OT - puberty COIS- Declaration of Interests A.G.S. has nothing to disclose. N.B. has nothing to disclose. T.B.H. has nothing to disclose. C.H.R.H. has nothing to disclose. EDAT- 2024/06/08 10:43 MHDA- 2024/09/30 00:42 CRDT- 2024/06/07 19:24 PHST- 2024/01/23 00:00 [received] PHST- 2024/05/13 00:00 [revised] PHST- 2024/06/01 00:00 [accepted] PHST- 2024/09/30 00:42 [medline] PHST- 2024/06/08 10:43 [pubmed] PHST- 2024/06/07 19:24 [entrez] AID - S0015-0282(24)00520-X [pii] AID - 10.1016/j.fertnstert.2024.06.001 [doi] PST - ppublish SO - Fertil Steril. 2024 Oct;122(4):715-726. doi: 10.1016/j.fertnstert.2024.06.001. Epub 2024 Jun 5. PMID- 38847638 OWN - NLM STAT- MEDLINE DCOM- 20240607 LR - 20240702 IS - 2229-7693 (Electronic) IS - 0019-557X (Linking) VI - 68 IP - 1 DP - 2024 Jan 1 TI - Development, Validity, and Reliability of a Food Frequency Questionnaire Eliciting the Dietary Advanced Glycation End Product Consumption among Obese Adolescents Aged 10-19 Years. PG - 83-88 LID - 10.4103/ijph.ijph_737_23 [doi] AB - BACKGROUND: Obesity has reached an alarming rate affecting all categories of the population. A tremendous rise in obesity has been observed in children and adolescents. In India, the prevalence of adolescent obesity is more than 30% of the population. Advanced glycation end products (AGEs) are a diverse group of compounds formed by the amalgamation of glucose and a protein moiety. These glycated compounds are found in processed foods subjected to high-temperature cooking techniques contributing to the formation of dietary AGEs (dAGEs). The enormous consumption of dAGE attributes to the development of metabolic diseases. OBJECTIVES: The objective of this study was to develop and validate a food frequency questionnaire (FFQ) among obese adolescents aged 10-19 years to gauge their dAGE consumption. MATERIALS AND METHODS: This questionnaire was developed from previous literature (15 articles), validated using the content validity ratio (CVR) by Lawshe, and estimated for reliability using the test-retest method. A pilot study was done among 50 obese adolescents aged 10-19 years, who completed the questionnaire twice, with a gap of 15 days. RESULTS: A total of 54 items were validated (CVR >/=0.99) from the 60 food items. A reliability score >0.7 was observed, and a significant correlation (P >/= 0.01) between the test and retest results was determined. CONCLUSION: Hence, this FFQ is reliable and can be used for future research studies to elicit dAGE consumption among obese adolescents. CI - Copyright (c) 2024 Copyright: (c) 2024 Indian Journal of Public Health. FAU - Punjabi, Juhi AU - Punjabi J AD - PhD Research Scholar, Department of Clinical Nutrition, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, India. FAU - Hemamalini, A J AU - Hemamalini AJ AD - Professor and Head, Department of Clinical Nutrition, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, India. FAU - Premkumar, Sarala AU - Premkumar S AD - Associate Professor, Department of Paediatrics, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India. LA - eng PT - Journal Article PT - Validation Study DEP - 20240404 PL - India TA - Indian J Public Health JT - Indian journal of public health JID - 0400673 RN - 0 (Glycation End Products, Advanced) RN - 0 (Dietary Advanced Glycation End Products) SB - IM MH - Humans MH - Adolescent MH - *Glycation End Products, Advanced MH - Child MH - Reproducibility of Results MH - Female MH - Male MH - India/epidemiology MH - Surveys and Questionnaires/standards MH - Young Adult MH - Pediatric Obesity MH - Pilot Projects MH - Dietary Advanced Glycation End Products EDAT- 2024/06/07 13:01 MHDA- 2024/06/07 13:02 CRDT- 2024/06/07 10:02 PHST- 2023/05/23 00:00 [received] PHST- 2023/07/29 00:00 [accepted] PHST- 2024/06/07 13:02 [medline] PHST- 2024/06/07 13:01 [pubmed] PHST- 2024/06/07 10:02 [entrez] AID - 01586002-202401000-00015 [pii] AID - 10.4103/ijph.ijph_737_23 [doi] PST - ppublish SO - Indian J Public Health. 2024 Jan 1;68(1):83-88. doi: 10.4103/ijph.ijph_737_23. Epub 2024 Apr 4. PMID- 38847438 OWN - NLM STAT- MEDLINE DCOM- 20241023 LR - 20260923 IS - 1531-8257 (Electronic) IS - 0885-3185 (Linking) VI - 39 IP - 9 DP - 2024 Sep TI - Digital Gait Outcomes for Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS): Discriminative, Convergent, and Ecological Validity in a Multicenter Study (PROSPAX). PG - 1544-1555 LID - 10.1002/mds.29876 [doi] AB - BACKGROUND: With treatment trials on the horizon, this study aimed to identify candidate digital-motor gait outcomes for autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), capturable by wearable sensors with multicenter validity, and ideally also ecological validity during free walking outside laboratory settings. METHODS: Cross-sectional multicenter study (four centers), with gait assessments in 36 subjects (18 ARSACS patients; 18 controls) using three body-worn sensors (Opal, APDM) in laboratory settings and free walking in public spaces. Sensor gait measures were analyzed for discriminative validity from controls, and for convergent (ie, clinical and patient relevance) validity by correlations with SPRS(mobility) (primary outcome) and Scale for the Assessment and Rating of Ataxia (SARA), Spastic Paraplegia Rating Scale (SPRS), and activities of daily living subscore of the Friedreich Ataxia Rating Scale (FARS-ADL) (exploratory outcomes). RESULTS: Of 30 hypothesis-based digital gait measures, 14 measures discriminated ARSACS patients from controls with large effect sizes (|Cliff's delta| > 0.8) in laboratory settings, with strongest discrimination by measures of spatiotemporal variability Lateral Step Deviation (delta = 0.98), SPcmp (delta = 0.94), and Swing CV (delta = 0.93). Large correlations with the SPRS(mobility) were observed for Swing CV (Spearman's rho = 0.84), Speed (rho = -0.63), and Harmonic Ratio V (rho = -0.62). During supervised free walking in a public space, 11/30 gait measures discriminated ARSACS from controls with large effect sizes. Large correlations with SPRS(mobility) were here observed for Swing CV (rho = 0.78) and Speed (rho = -0.69), without reductions in effect sizes compared with laboratory settings. CONCLUSIONS: We identified a promising set of digital-motor candidate gait outcomes for ARSACS, applicable in multicenter settings, correlating with patient-relevant health aspects, and with high validity also outside laboratory settings, thus simulating real-life walking with higher ecological validity. (c) 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. CI - (c) 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. FAU - Beichert, Lukas AU - Beichert L AUID- ORCID: 0009-0000-9259-9230 AD - Division Translational Genomics of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center for Neurology, University of Tubingen, Tubingen, Germany. AD - German Center for Neurodegenerative Diseases (DZNE), University of Tubingen, Tubingen, Germany. FAU - Ilg, Winfried AU - Ilg W AUID- ORCID: 0000-0002-1537-1336 AD - Section Computational Sensomotorics, Hertie Institute for Clinical Brain Research, Tubingen, Germany. AD - Centre for Integrative Neuroscience (CIN), Tubingen, Germany. FAU - Kessler, Christoph AU - Kessler C AD - Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center for Neurology, University of Tubingen, Tubingen, Germany. FAU - Traschutz, Andreas AU - Traschutz A AUID- ORCID: 0000-0002-8165-5898 AD - Division Translational Genomics of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center for Neurology, University of Tubingen, Tubingen, Germany. AD - German Center for Neurodegenerative Diseases (DZNE), University of Tubingen, Tubingen, Germany. FAU - Reich, Selina AU - Reich S AD - Division Translational Genomics of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center for Neurology, University of Tubingen, Tubingen, Germany. AD - German Center for Neurodegenerative Diseases (DZNE), University of Tubingen, Tubingen, Germany. FAU - Santorelli, Filippo M AU - Santorelli FM AD - Molecular Medicine, IRCCS Fondazione Stella Maris, Pisa, Italy. FAU - Basak, Ayse Nazli AU - Basak AN AUID- ORCID: 0000-0001-6977-2517 AD - Koc University, Translational Medicine Research Center, KUTTAM-NDAL, Istanbul, Turkey. FAU - Gagnon, Cynthia AU - Gagnon C AUID- ORCID: 0000-0003-2829-8470 AD - Groupe de recherche interdisciplinaire sur les maladies neuromusculaires (GRIMN), Centre integre universitaire de sante et de services sociaux du Saguenay-Lac-Saint-Jean, Quebec, Canada. AD - Centre de recherche du Centre integre universitaire de sante et de services sociaux du Saguenay-Lac-Saint-Jean, Quebec, Canada. AD - Faculte de medecine et des sciences de la sante, Universite de Sherbrooke, Quebec, Canada. CN - PROSPAX Consortium FAU - Schule, Rebecca AU - Schule R AD - German Center for Neurodegenerative Diseases (DZNE), University of Tubingen, Tubingen, Germany. AD - Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany. AD - Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, Tubingen, Germany. FAU - Synofzik, Matthis AU - Synofzik M AUID- ORCID: 0000-0002-2280-7273 AD - Division Translational Genomics of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center for Neurology, University of Tubingen, Tubingen, Germany. AD - German Center for Neurodegenerative Diseases (DZNE), University of Tubingen, Tubingen, Germany. LA - eng GR - 441409627/Deutsche Forschungsgemeinschaft/ GR - Else Kroner-Fresenius-Stiftung/ GR - 439-0-0/Medizinischen Fakultat, Eberhard Karls Universitat Tubingen/ GR - RC 5x1000/Ministero della Salute/ GR - RF-2019- 12370417/Ministero della Salute/ PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20240607 PL - United States TA - Mov Disord JT - Movement disorders : official journal of the Movement Disorder Society JID - 8610688 RN - Spastic ataxia Charlevoix-Saguenay type SB - IM MH - Humans MH - Male MH - Female MH - *Spinocerebellar Ataxias/physiopathology/diagnosis/congenital MH - Adult MH - Cross-Sectional Studies MH - *Muscle Spasticity/physiopathology/diagnosis MH - Middle Aged MH - Young Adult MH - Gait/physiology MH - Gait Disorders, Neurologic/physiopathology/diagnosis/etiology MH - Adolescent MH - Activities of Daily Living MH - Walking/physiology MH - Wearable Electronic Devices OTO - NOTNLM OT - ARSACS OT - digital gait outcomes OT - outcome measures OT - spastic ataxia OT - wearable sensors EDAT- 2024/06/07 12:53 MHDA- 2024/10/23 22:28 CRDT- 2024/06/07 08:13 PHST- 2024/05/08 00:00 [revised] PHST- 2024/01/03 00:00 [received] PHST- 2024/05/17 00:00 [accepted] PHST- 2024/10/23 22:28 [medline] PHST- 2024/06/07 12:53 [pubmed] PHST- 2024/06/07 08:13 [entrez] AID - 10.1002/mds.29876 [doi] PST - ppublish SO - Mov Disord. 2024 Sep;39(9):1544-1555. doi: 10.1002/mds.29876. Epub 2024 Jun 7. PMID- 38844498 OWN - NLM STAT- MEDLINE DCOM- 20240606 LR - 20240609 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Jun 6 TI - Predictive approach of health indicators from the physical activity habits of active youth. PG - 13008 LID - 10.1038/s41598-024-62697-6 [doi] LID - 13008 AB - The aim of this study is to analyse the relationship between sport modalities practiced, physical fitness, body composition, and healthy habits in an active young population, using a statistical model for prediction. A total of 2255 (1528 boys and 727 girls) children and adolescents aged 6-17 years old who were involved in extracurricular sports from rural areas of Spain participated. Physical fitness was assessed through validated field test and, body composition was determinated using bioelectrical impedance analysis. Adherence to the Mediterranean diet was assessed by KIDMED questionnaire. The general sport variable was significant in VO(2)max when comparing the invasion and combat modalities to the reference level (court/net). The sex and age variables revealed significant differences in all physical fitness and body composition parameters. Health parameters, such as hours of additional practice, adherence to the Mediterranean diet, and previous experience, showed significant differences. The study concludes that the sport modality variables of training, sex, age, and maturational period have an impact on body composition and fitness parameters in this population. Therefore, by focusing on factors associated with lower values in health indicators, we can prevent health problems during adulthood, such as cardiorespiratory deficits. CI - (c) 2024. The Author(s). FAU - Moreno-Gonzalez, Laura AU - Moreno-Gonzalez L AUID- ORCID: 0009-0007-5107-7664 AD - IGOID Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Toledo, Spain. FAU - Manzano-Carrasco, Samuel AU - Manzano-Carrasco S AUID- ORCID: 0000-0002-1468-7398 AD - Department of Communication and Education, Universidad Loyola Andalucia, Sevilla, Spain. smanzano@uloyola.es. FAU - Felipe, Jose Luis AU - Felipe JL AUID- ORCID: 0000-0002-2029-1277 AD - IGOID Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Toledo, Spain. FAU - Alonso-Callejo, Antonio AU - Alonso-Callejo A AUID- ORCID: 0000-0003-1604-4916 AD - IGOID Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Toledo, Spain. FAU - Gallardo, Leonor AU - Gallardo L AUID- ORCID: 0000-0002-6296-6121 AD - IGOID Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Toledo, Spain. FAU - Garcia-Unanue, Jorge AU - Garcia-Unanue J AUID- ORCID: 0000-0002-1741-5566 AD - IGOID Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Toledo, Spain. LA - eng PT - Journal Article DEP - 20240606 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Male MH - Adolescent MH - Female MH - Child MH - *Exercise MH - *Body Composition MH - *Physical Fitness/physiology MH - Spain MH - Diet, Mediterranean MH - Sports MH - Surveys and Questionnaires MH - Habits PMC - PMC11156987 OTO - NOTNLM OT - Adolescents OT - Body composition OT - Children OT - Physical fitness OT - Sport COIS- The authors declare no competing interests. EDAT- 2024/06/07 00:43 MHDA- 2024/06/07 00:44 PMCR- 2024/06/06 CRDT- 2024/06/06 23:17 PHST- 2023/12/19 00:00 [received] PHST- 2024/05/20 00:00 [accepted] PHST- 2024/06/07 00:44 [medline] PHST- 2024/06/07 00:43 [pubmed] PHST- 2024/06/06 23:17 [entrez] PHST- 2024/06/06 00:00 [pmc-release] AID - 10.1038/s41598-024-62697-6 [pii] AID - 62697 [pii] AID - 10.1038/s41598-024-62697-6 [doi] PST - epublish SO - Sci Rep. 2024 Jun 6;14(1):13008. doi: 10.1038/s41598-024-62697-6. PMID- 38841418 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240607 IS - 0974-5963 (Print) IS - 1742-6413 (Electronic) IS - 1742-6413 (Linking) VI - 21 DP - 2024 TI - The endometrial cancer detection using non-invasive hypermethylation of CDO1 and CELF4 genes in women with postmenopausal bleeding in Northwest China. PG - 15 LID - 10.25259/Cytojournal_78_2023 [doi] LID - 15 AB - OBJECTIVE: The objective of this study was to verify the clinical predictive performance of methylated cysteine dioxygenase type 1 (CDO1(m)) and CUGBP Elav-like family member 4 (CELF4(m)) in endometrial cancer (EC) women with postmenopausal bleeding (PMB). MATERIAL AND METHODS: A single-center, prospective, and case-control study was conducted in the Gansu Provincial Maternity and Child-care Hospital with 138 female postmenopausal patients enrolled in 2022. All patients underwent body mass index (BMI) detection, transvaginal ultrasonography (TVUS) detection, carbohydrate antigen 125 detection, and the cervical exfoliated cell CDO1/CELF4 gene methylation detection to analyze the sensitivity, specificity, and accuracy of different screening tests statistically with the biopsy and/or dilation and curettage (D&C) pathological diagnosis under hysteroscopy as the gold standard. RESULTS: There was no significant difference in age between the EC group and the non-EC group, P = 0.492. Using quantitative polymerase chain reaction (qPCR) technology, we validated the CDO1 and CELF4 methylation detection with 87.5% sensitivity and 95.9% specificity as a useful strategy for the triage of women with PMB for the detection of EC. In addition, 100% of type II EC (n = 6) were positively detected by the CDO1 or CELF4 methylation test. CONCLUSION: The CDO1 and CELF4 methylation test with high specificity as an auxiliary diagnostic tool or alternative method provides physicians with a reference to distinguish between benign and malignant tumors in women with postmenopausal bleeding, to justify the necessity of using invasive methods to confirm diagnosis. CI - (c) 2024 The Author(s). Published by Scientific Scholar. FAU - Cai, Bingxin AU - Cai B AD - Department of Obstetrics and Gynecology, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, China. FAU - Du, Jun AU - Du J AD - Department of Obstetrics and Gynecology, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, China. FAU - Wang, Yishan AU - Wang Y AD - Department of Medical Laboratory, Beijing Origin-Poly Bio-Tec Co., Ltd., Beijing, China. FAU - Liu, Zhijie AU - Liu Z AD - Department of Obstetrics and Gynecology, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, China. FAU - Wang, Yan AU - Wang Y AD - Department of Obstetrics and Gynecology, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, China. FAU - Li, Liuyu AU - Li L AD - Department of Obstetrics and Gynecology, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, China. FAU - Liu, Pei AU - Liu P AD - Department of Medical Laboratory, Beijing Origin-Poly Bio-Tec Co., Ltd., Beijing, China. FAU - Wang, Linhai AU - Wang L AD - Department of Medical Laboratory, Beijing Origin-Poly Bio-Tec Co., Ltd., Beijing, China. FAU - Liu, Qing AU - Liu Q AD - Department of Obstetrics and Gynecology, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, China. FAU - Meng, Zhaoyan AU - Meng Z AD - Department of Obstetrics and Gynecology, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, China. LA - eng PT - Journal Article DEP - 20240425 PL - United States TA - Cytojournal JT - CytoJournal JID - 101231642 PMC - PMC11152555 OTO - NOTNLM OT - CDO1 OT - CELF4 OT - Endometrial cancer OT - Methylation OT - Postmenopausal bleeding COIS- Authors WY, WL, and LP were employed by the company Beijing Origin-Poly Bio-Tec Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. All authors in Gansu Provincial Maternity and Child-care Hospital declare they have no commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/06/06 06:43 MHDA- 2024/06/06 06:44 PMCR- 2024/04/25 CRDT- 2024/06/06 04:10 PHST- 2023/09/28 00:00 [received] PHST- 2023/12/28 00:00 [accepted] PHST- 2024/06/06 06:44 [medline] PHST- 2024/06/06 06:43 [pubmed] PHST- 2024/06/06 04:10 [entrez] PHST- 2024/04/25 00:00 [pmc-release] AID - 10.25259/Cytojournal_78_2023 [pii] AID - 10.25259/Cytojournal_78_2023 [doi] PST - epublish SO - Cytojournal. 2024 Apr 25;21:15. doi: 10.25259/Cytojournal_78_2023. eCollection 2024. PMID- 38840739 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240607 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 15 DP - 2024 TI - Fostering emotional well-being in adolescents: the role of physical activity, emotional intelligence, and interpersonal forgiveness. PG - 1408022 LID - 10.3389/fpsyg.2024.1408022 [doi] LID - 1408022 AB - INTRODUCTION: Adolescence is considered a stress-sensitive developmental period, and the escalating and sustained pressure during this phase poses a significant threat to the mental and physical well-being of adolescents. Therefore, enhancing positive emotions in adolescents is crucial. This study aims to investigate the impact of physical activity on the emotional intelligence, interpersonal forgiveness, and positive emotions of adolescents. METHODS: Using a cluster sampling method, data were collected from 500 adolescents in four schools across the Xiangxi Tujia and Miao Autonomous Prefecture of Hunan Province, China. A total of 428 valid questionnaires were collected and analyzed. The study employed AMOS v.23 to construct a structural equation model to validate the hypotheses. RESULTS: The results indicate that physical activity significantly influences the emotional intelligence, interpersonal forgiveness, and positive emotions of adolescents. Furthermore, emotional intelligence and interpersonal forgiveness mediate the relationship between physical activity and positive emotions. DISCUSSION: Based on these findings, collaborative efforts from government agencies, schools, and families are essential to provide robust support for adolescents' participation in physical activity, encouraging more adolescents to actively engage in sports. CI - Copyright (c) 2024 Yang, Jing, He and Wang. FAU - Yang, Shicheng AU - Yang S AD - School of Physical Education, Hunan University of Science and Technology, Xiangtan, China. FAU - Jing, Longjun AU - Jing L AD - School of Physical Education, Hunan University of Science and Technology, Xiangtan, China. FAU - He, Qianqian AU - He Q AD - Faculty of Economics, Chulalongkorn University, Bangkok, Thailand. FAU - Wang, Huilin AU - Wang H AD - School of Business, Hunan University of Science and Technology, Xiangtan, China. LA - eng PT - Journal Article DEP - 20240522 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC11150801 OTO - NOTNLM OT - adolescents OT - emotional intelligence OT - interpersonal forgiveness OT - physical activity OT - positive emotions COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/06/06 06:43 MHDA- 2024/06/06 06:44 PMCR- 2024/05/22 CRDT- 2024/06/06 03:48 PHST- 2024/03/27 00:00 [received] PHST- 2024/05/03 00:00 [accepted] PHST- 2024/06/06 06:44 [medline] PHST- 2024/06/06 06:43 [pubmed] PHST- 2024/06/06 03:48 [entrez] PHST- 2024/05/22 00:00 [pmc-release] AID - 10.3389/fpsyg.2024.1408022 [doi] PST - epublish SO - Front Psychol. 2024 May 22;15:1408022. doi: 10.3389/fpsyg.2024.1408022. eCollection 2024. PMID- 38839196 OWN - NLM STAT- MEDLINE DCOM- 20240605 LR - 20250514 IS - 1938-3207 (Electronic) IS - 0002-9165 (Print) IS - 0002-9165 (Linking) VI - 119 IP - 6 DP - 2024 Jun TI - Food (in)security in relation to nutrition (in)security in a national cross-sectional sample of Supplemental Nutrition Assistance Program participants: considerations of an emerging construct. PG - 1475-1484 LID - S0002-9165(24)00390-3 [pii] LID - 10.1016/j.ajcnut.2024.03.020 [doi] AB - BACKGROUND: Food insecurity, lack of access to sufficient food for an active, healthy life, is a persistent problem in the United States. Recently, nutrition security has emerged as a new concept. However, limited research exists examining how nutrition security relates to the established concept of food security. OBJECTIVES: This study assessed a recent metric of nutrition security and explored how well it describes the underlying construct among a sample of Supplemental Nutrition Assistance Program (SNAP) participants. We examined the correlation between food and nutrition security and demographic predictors of joint food and nutrition security status. METHODS: We conducted a national, web-based survey (Qualtrics; 30 September-19 October, 2022) in English and Spanish of adults aged >/=18 y (n = 1454) who reported receiving SNAP benefits in the past 12 mo. We measured food security using the US Department of Agriculture 6-item Food Security Survey and assessed nutrition security using the Gretchen Swanson Center for Nutrition Household Nutrition Security measure. We used multinominal logistic regression to examine demographic predictors of food and nutrition security. RESULTS: The majority (80.4%) of SNAP participants experienced food insecurity, and 59.1% reported experiencing nutrition insecurity. Food and nutrition security were moderately correlated (0.41); 55.6% of SNAP participants were both food and nutrition insecure, 3.5% were food secure but nutrition insecure, 24.8% were food insecure but nutrition secure, and 16.1% were both food and nutrition secure. Of SNAP participants, 24.8% reported experiencing food insecurity but not nutrition insecurity. Hispanic ethnicity and Southern residence were associated with joint food and nutrition insecurity. CONCLUSIONS: These findings raise questions about how nutrition security is conceptualized and measured and its added value beyond existing food security measurement scales. Further research is needed to understand differences in food and nutrition security experiences and risk factors and determine a validated definition and measure of nutrition security for future policy solutions. CI - Copyright (c) 2024 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Tucker, Anna C AU - Tucker AC AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. Electronic address: atucke31@jh.edu. FAU - Bresnahan, Carolyn AU - Bresnahan C AD - Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. FAU - John, Sara AU - John S AD - Center for Science in the Public Interest, Washington, DC, United States. FAU - Johnson, Joelle AU - Johnson J AD - Center for Science in the Public Interest, Washington, DC, United States. FAU - Leung, Cindy W AU - Leung CW AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Mui, Yeeli AU - Mui Y AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. FAU - Hager, Erin R AU - Hager ER AD - Department of Population, Family, and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States; Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, United States. FAU - Wolfson, Julia A AU - Wolfson JA AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States; Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. LA - eng GR - T32 HL007024/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20240513 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM CIN - Am J Clin Nutr. 2024 Jun;119(6):1381-1382. doi: 10.1016/j.ajcnut.2024.04.017. PMID: 38839193 MH - Humans MH - *Food Assistance MH - Female MH - Male MH - Adult MH - Cross-Sectional Studies MH - United States MH - Middle Aged MH - *Food Security MH - Nutritional Status MH - Food Insecurity MH - Young Adult MH - Adolescent MH - Food Supply MH - Nutrition Surveys PMC - PMC11196887 OTO - NOTNLM OT - Supplemental Nutrition Assistance Program OT - adults OT - food assistance OT - food policy OT - food security OT - nutrition security EDAT- 2024/06/06 01:14 MHDA- 2024/06/06 01:15 PMCR- 2025/05/13 CRDT- 2024/06/05 21:00 PHST- 2023/10/26 00:00 [received] PHST- 2024/03/12 00:00 [revised] PHST- 2024/03/22 00:00 [accepted] PHST- 2024/06/06 01:15 [medline] PHST- 2024/06/06 01:14 [pubmed] PHST- 2024/06/05 21:00 [entrez] PHST- 2025/05/13 00:00 [pmc-release] AID - S0002-9165(24)00390-3 [pii] AID - 10.1016/j.ajcnut.2024.03.020 [doi] PST - ppublish SO - Am J Clin Nutr. 2024 Jun;119(6):1475-1484. doi: 10.1016/j.ajcnut.2024.03.020. Epub 2024 May 13. PMID- 38837450 OWN - NLM STAT- MEDLINE DCOM- 20240605 LR - 20240916 IS - 1365-2214 (Electronic) IS - 0305-1862 (Linking) VI - 50 IP - 4 DP - 2024 Jul TI - The relationship between video games and social-emotional delay in Chinese rural preschoolers: A comparison of five types of media video games and social-emotional delay. PG - e13288 LID - 10.1111/cch.13288 [doi] AB - BACKGROUND: Recent studies have revealed a negative relationship between children's digital media use and social-emotional development. However, few studies distinguish between different digital devices and the different functions they provide that may lead to different outcomes. METHODS: This study explored the relationship between young children's time spent on various digital devices and their social-emotional delay based on a survey of 1182 preschoolers (3 to 6 years old) in rural China. Children's social-emotional delay was assessed through a validated screening tool (ASQ-SE II). RESULTS: Children's time spent on television, computers, tablets, or smartphones was not associated with their social-emotional delay. However, their risk of social-emotional delay increased as their time spent on game consoles increased. This relationship was reflected in five of the seven behavioural areas of children's social-emotional development (i.e., self-regulation, compliance, affect, social communications, and interactions with people). Moreover, it did not vary between children with different socioeconomic statuses. CONCLUSIONS: This study suggests a possible relationship between children's social-emotional delay and video games, which might need to be paid more attention to than other media types. CI - (c) 2024 John Wiley & Sons Ltd. FAU - Gou, He AU - Gou H AUID- ORCID: 0000-0001-9962-1736 AD - School of Journalism and New Media, Xi'an Jiaotong University, Xi'an, China. FAU - Yang, Yinglong AU - Yang Y AUID- ORCID: 0009-0008-1523-2636 AD - Guangming School of Journalism and Communication, China University of Political Science and Law, Beijing, China. LA - eng GR - 22YJC760114/Humanities and Social Sciences Research Project Funds of the Ministry of Education of China/ GR - SK2022032/Fundamental Research Funds for the Central Universities/ PT - Comparative Study PT - Journal Article PL - England TA - Child Care Health Dev JT - Child: care, health and development JID - 7602632 SB - IM EIN - Child Care Health Dev. 2024 Sep;50(5):e13309. doi: 10.1111/cch.13309. PMID: 39056268 MH - Humans MH - Child, Preschool MH - *Video Games/psychology MH - Male MH - Female MH - China MH - *Rural Population MH - Television MH - Child Development MH - Child MH - Emotions MH - Screen Time MH - Child Behavior/psychology MH - East Asian People OTO - NOTNLM OT - digital media OT - game consoles OT - preschoolers OT - social-emotional delay OT - video games EDAT- 2024/06/05 19:12 MHDA- 2024/06/05 19:13 CRDT- 2024/06/05 12:19 PHST- 2024/04/18 00:00 [revised] PHST- 2023/12/21 00:00 [received] PHST- 2024/05/16 00:00 [accepted] PHST- 2024/06/05 19:13 [medline] PHST- 2024/06/05 19:12 [pubmed] PHST- 2024/06/05 12:19 [entrez] AID - 10.1111/cch.13288 [doi] PST - ppublish SO - Child Care Health Dev. 2024 Jul;50(4):e13288. doi: 10.1111/cch.13288. PMID- 38836573 OWN - NLM STAT- MEDLINE DCOM- 20240626 LR - 20240626 IS - 1466-447X (Electronic) IS - 0264-0414 (Linking) VI - 42 IP - 8 DP - 2024 Apr TI - Between-session reliability of dry-land and in-water tests to measure inter-limb asymmetries in swimmers. PG - 737-750 LID - 10.1080/02640414.2024.2363695 [doi] AB - The aims of the present study were to: i) analyse the between-session reliability of dry-land and in-water swimming tests, and ii) investigate the prevalence of meaningful asymmetries in swimming athletes. Twenty-eight swimmers (21 males, 7 females) performed anthropometric, shoulder range of motion (ROM), countermovement jump, shoulder isokinetic torque, and 15-s tethered swimming tests two times, 1 week apart. Inter-limb asymmetries were calculated for each variable. Raw data reliability was determined using the intraclass coefficient correlation (ICC) and the typical error of measurement (TEM), and effect size (ES) was used to determine systematic bias between test sessions. At an individual level, inter-limb asymmetries were compared to the coefficient of variation (CV) to determine whether they were real. The between-session reliability was good to excellent (0.75 to 1.00) for most of the raw data, except for ROM. Between-session ES was predominately "trivial" or "small" for raw data and asymmetries, reinforcing that the values did not change significantly between the sessions. In addition, real asymmetries were seen in some tested metrics, depending on the test. In conclusion, the tested variables presented good levels of between-session reliability and were able to detect real and consistent asymmetries. FAU - Knihs, Debora A AU - Knihs DA AUID- ORCID: 0000-0002-9217-7713 AD - Biomechanics Laboratory, Centre of Sports, Federal University of Santa Catarina, Florianopolis, Brazil. FAU - Bishop, Chris AU - Bishop C AUID- ORCID: 0000-0002-1505-1287 AD - Faculty of Science and Technology, London Sports Institute, Middlesex University, London, UK. FAU - Zimmermann, Haiko B AU - Zimmermann HB AUID- ORCID: 0000-0003-3703-5808 AD - Biomechanics Laboratory, Centre of Sports, Federal University of Santa Catarina, Florianopolis, Brazil. FAU - Dal Pupo, Juliano AU - Dal Pupo J AUID- ORCID: 0000-0003-4084-9474 AD - Biomechanics Laboratory, Centre of Sports, Federal University of Santa Catarina, Florianopolis, Brazil. LA - eng PT - Journal Article DEP - 20240605 PL - England TA - J Sports Sci JT - Journal of sports sciences JID - 8405364 SB - IM MH - Humans MH - *Swimming/physiology MH - Male MH - Reproducibility of Results MH - Female MH - Adolescent MH - *Range of Motion, Articular/physiology MH - *Exercise Test/methods MH - Young Adult MH - Torque MH - Anthropometry MH - Shoulder/physiology OTO - NOTNLM OT - Swimming OT - biomechanics OT - performance OT - side-to-side differences EDAT- 2024/06/05 13:12 MHDA- 2024/06/26 06:42 CRDT- 2024/06/05 08:23 PHST- 2024/06/26 06:42 [medline] PHST- 2024/06/05 13:12 [pubmed] PHST- 2024/06/05 08:23 [entrez] AID - 10.1080/02640414.2024.2363695 [doi] PST - ppublish SO - J Sports Sci. 2024 Apr;42(8):737-750. doi: 10.1080/02640414.2024.2363695. Epub 2024 Jun 5. PMID- 38834671 OWN - NLM STAT- MEDLINE DCOM- 20240604 LR - 20240607 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Jun 4 TI - Applying an explainable machine learning model might reduce the number of negative appendectomies in pediatric patients with a high probability of acute appendicitis. PG - 12772 LID - 10.1038/s41598-024-63513-x [doi] LID - 12772 AB - The diagnosis of acute appendicitis and concurrent surgery referral is primarily based on clinical presentation, laboratory and radiological imaging. However, utilizing such an approach results in as much as 10-15% of negative appendectomies. Hence, in the present study, we aimed to develop a machine learning (ML) model designed to reduce the number of negative appendectomies in pediatric patients with a high clinical probability of acute appendicitis. The model was developed and validated on a registry of 551 pediatric patients with suspected acute appendicitis that underwent surgical treatment. Clinical, anthropometric, and laboratory features were included for model training and analysis. Three machine learning algorithms were tested (random forest, eXtreme Gradient Boosting, logistic regression) and model explainability was obtained. Random forest model provided the best predictions achieving mean specificity and sensitivity of 0.17 +/- 0.01 and 0.997 +/- 0.001 for detection of acute appendicitis, respectively. Furthermore, the model outperformed the appendicitis inflammatory response (AIR) score across most sensitivity-specificity combinations. Finally, the random forest model again provided the best predictions for discrimination between complicated appendicitis, and either uncomplicated acute appendicitis or no appendicitis at all, with a joint mean sensitivity of 0.994 +/- 0.002 and specificity of 0.129 +/- 0.009. In conclusion, the developed ML model might save as much as 17% of patients with a high clinical probability of acute appendicitis from unnecessary surgery, while missing the needed surgery in only 0.3% of cases. Additionally, it showed better diagnostic accuracy than the AIR score, as well as good accuracy in predicting complicated acute appendicitis over uncomplicated and negative cases bundled together. This may be useful in centers that advocate for the conservative treatment of uncomplicated appendicitis. Nevertheless, external validation is needed to support these findings. CI - (c) 2024. The Author(s). FAU - Males, Ivan AU - Males I AD - Department of Abdominal Surgery, University Hospital of Split, Spinciceva 1, 21000, Split, Croatia. FAU - Boban, Zvonimir AU - Boban Z AD - Department of Medical Physics and Biophysics, School of Medicine, University of Split, Soltanska 2A, 21000, Split, Croatia. FAU - Kumric, Marko AU - Kumric M AD - Department of Pathophysiology, School of Medicine, University of Split, Soltanska 2A, 21000, Split, Croatia. AD - Laboratory for Cardiometabolic Research, School of Medicine, University of Split, Soltanska 2A, 21000, Split, Croatia. FAU - Vrdoljak, Josip AU - Vrdoljak J AD - Department of Pathophysiology, School of Medicine, University of Split, Soltanska 2A, 21000, Split, Croatia. AD - Laboratory for Cardiometabolic Research, School of Medicine, University of Split, Soltanska 2A, 21000, Split, Croatia. FAU - Berkovic, Karlotta AU - Berkovic K AD - Department of Surgery, School of Medicine, University of Split, Soltanska 2A, 21000, Split, Croatia. FAU - Pogorelic, Zenon AU - Pogorelic Z AD - Department of Surgery, School of Medicine, University of Split, Soltanska 2A, 21000, Split, Croatia. zenon.pogorelic@mefst.hr. AD - Department of Pediatric Surgery, University Hospital of Split, Spinciceva 1, 21000, Split, Croatia. zenon.pogorelic@mefst.hr. FAU - Bozic, Josko AU - Bozic J AD - Department of Medical Physics and Biophysics, School of Medicine, University of Split, Soltanska 2A, 21000, Split, Croatia. josko.bozic@mefst.hr. AD - Department of Pathophysiology, School of Medicine, University of Split, Soltanska 2A, 21000, Split, Croatia. josko.bozic@mefst.hr. LA - eng PT - Journal Article DEP - 20240604 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Appendicitis/surgery/diagnosis MH - *Appendectomy MH - Child MH - *Machine Learning MH - Female MH - Male MH - Adolescent MH - Child, Preschool MH - Acute Disease MH - Probability MH - Sensitivity and Specificity MH - Algorithms PMC - PMC11150468 OTO - NOTNLM OT - Acute appendicitis OT - Appendectomy OT - Children OT - Machine learning OT - Pediatric surgery COIS- The authors declare no competing interests. EDAT- 2024/06/05 02:08 MHDA- 2024/06/05 02:09 PMCR- 2024/06/04 CRDT- 2024/06/04 23:20 PHST- 2023/12/28 00:00 [received] PHST- 2024/05/29 00:00 [accepted] PHST- 2024/06/05 02:09 [medline] PHST- 2024/06/05 02:08 [pubmed] PHST- 2024/06/04 23:20 [entrez] PHST- 2024/06/04 00:00 [pmc-release] AID - 10.1038/s41598-024-63513-x [pii] AID - 63513 [pii] AID - 10.1038/s41598-024-63513-x [doi] PST - epublish SO - Sci Rep. 2024 Jun 4;14(1):12772. doi: 10.1038/s41598-024-63513-x. PMID- 38833336 OWN - NLM STAT- MEDLINE DCOM- 20240626 LR - 20240626 IS - 1466-447X (Electronic) IS - 0264-0414 (Linking) VI - 42 IP - 8 DP - 2024 Apr TI - Strength, speed, and anthropometric predictors of in-game batting performance in baseball. PG - 720-727 LID - 10.1080/02640414.2024.2363679 [doi] AB - A key focus of sports science research is the identification of quantitative assessments that can predict players' on-field performance and developmental potential. Despite efforts to establish predictive models, there are few validated measures that show reliable associations and large gaps in understanding. Here, we test a multidimensional battery of assessments developed through the USA Baseball, Prospect Development Pipeline that capture strength and functional movement abilities, and anthropometric characteristics, in a two-year cohort of collegiate baseball players from the Appalachian League. Swing propensity metrics for Zone Contact Percentage (ZCP: proportion pitches in strike zone swung at and hit) and Hard-Hit Percentage (HHP: proportion in-play balls with exit velocity >/= 95 mph) were calculated on 189 players. Models testing hierarchical combinations of anthropometric and anthropometric plus assessment data were implemented using nested cross-validation with random forest and elastic net regression. Results indicate that anthropometric features account for 29% of variance in ZCP and 50-55% of HHP, while the addition of assessment contributed an additional 1-3% to ZCP and 5-12% to HHP, with top predictors coming from PDP strength and power assessments. These findings delineate contributions of andromorphic and physical abilities to in-game baseball performance using a validated assessment battery and advanced game statistics. FAU - Kohn, Jordan N AU - Kohn JN AUID- ORCID: 0000-0001-8546-2076 AD - Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, USA. FAU - Lochhead, Liam AU - Lochhead L AUID- ORCID: 0000-0001-8368-5292 AD - Department of Psychiatry, University of California, San Diego, USA. FAU - Feng, Jiren AU - Feng J AD - Department of Psychiatry, University of California, San Diego, USA. FAU - Bobb, Ryan AU - Bobb R AD - Department of Athletics, University of California, San Diego, USA. FAU - Appelbaum, L Gregory AU - Appelbaum LG AUID- ORCID: 0000-0002-3184-6725 AD - Department of Psychiatry, University of California, San Diego, USA. LA - eng PT - Journal Article DEP - 20240604 PL - England TA - J Sports Sci JT - Journal of sports sciences JID - 8405364 SB - IM MH - *Baseball/physiology MH - Humans MH - *Athletic Performance/physiology MH - *Anthropometry MH - Young Adult MH - Male MH - *Muscle Strength/physiology MH - Adolescent MH - Motor Skills/physiology OTO - NOTNLM OT - Batting performance OT - assessments OT - athlete OT - machine learning OT - prediction EDAT- 2024/06/04 18:42 MHDA- 2024/06/26 06:42 CRDT- 2024/06/04 12:23 PHST- 2024/06/26 06:42 [medline] PHST- 2024/06/04 18:42 [pubmed] PHST- 2024/06/04 12:23 [entrez] AID - 10.1080/02640414.2024.2363679 [doi] PST - ppublish SO - J Sports Sci. 2024 Apr;42(8):720-727. doi: 10.1080/02640414.2024.2363679. Epub 2024 Jun 4. PMID- 38833048 OWN - NLM STAT- MEDLINE DCOM- 20251001 LR - 20251001 IS - 1614-7499 (Electronic) IS - 0944-1344 (Linking) VI - 32 IP - 37 DP - 2025 Aug TI - Occurrence and health risk estimate of organochlorine pesticides in fruits and vegetables matrices. PG - 21800-21815 LID - 10.1007/s11356-024-33823-8 [doi] AB - Occurrence of 20 organochlorine pesticides (OCPs) in 60 organic and non-organic fruits and vegetables matrices was undertaken using QuEChERS Method EN 15662 for sample preparation analyzed by gas chromatography-mass spectrometry (GC-MS/MS). The procedural method was validated by spiking the OCP standard solutions at three fortified levels at 10, 50, and 100 microg/kg wet weight (ww) to the real matrix of fruit and vegetable with good recovery ranging from 75 to 108% with relative standard deviation (RSD) 0.0). As compared to the 1st DII-quartile (least dietary-inflammatory group), the adjusted prevalence ratio (95% confidence interval) for the presence of multimorbidity was 1.46(0.87, 2.46) for 2nd, 1.75(1.05, 2.89) for 3rd, and 1.77(1.06, 2.96) for 4th DII-quartile (p-trend = 0.021). There was no evidence of an interaction between DII and sex on multimorbidity. CONCLUSIONS: Dietary-inflammation had a positive linear association with the multimorbidity, which suggest that even modest reduction in dietary-inflammation may reduce the multimorbidity burden. CI - (c) 2024 The Authors. FAU - Mahajan, Hemant AU - Mahajan H AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, India. FAU - Lieber, Judith AU - Lieber J AD - London School of Hygiene & Tropical Medicine, London, UK. FAU - Carson Mallinson, Poppy Alice AU - Carson Mallinson PA AD - London School of Hygiene & Tropical Medicine, London, UK. FAU - Bhogadi, Santhi AU - Bhogadi S AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, India. FAU - Banjara, Santosh Kumar AU - Banjara SK AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, India. FAU - Kinra, Sanjay AU - Kinra S AD - London School of Hygiene & Tropical Medicine, London, UK. FAU - Kulkarni, Bharati AU - Kulkarni B AD - Indian Council of Medical Research, Delhi, India. LA - eng GR - MC_PC_MR/T038292/1/MRC_/Medical Research Council/United Kingdom PT - Journal Article PL - United States TA - Hum Nutr Metab JT - Human nutrition & metabolism JID - 9918487343906676 PMC - PMC11052728 OTO - NOTNLM OT - Cardiovascular OT - Diet OT - India OT - Inflammation OT - Mental health OT - Multimorbidity COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/06/03 06:42 MHDA- 2024/06/03 06:43 PMCR- 2024/06/01 CRDT- 2024/06/03 04:40 PHST- 2023/05/31 00:00 [received] PHST- 2023/08/17 00:00 [revised] PHST- 2024/02/08 00:00 [accepted] PHST- 2024/06/03 06:43 [medline] PHST- 2024/06/03 06:42 [pubmed] PHST- 2024/06/03 04:40 [entrez] PHST- 2024/06/01 00:00 [pmc-release] AID - S2666-1497(24)00016-1 [pii] AID - 200254 [pii] AID - 10.1016/j.hnm.2024.200254 [doi] PST - ppublish SO - Hum Nutr Metab. 2024 Jun;36:None. doi: 10.1016/j.hnm.2024.200254. PMID- 38823862 OWN - NLM STAT- MEDLINE DCOM- 20240601 LR - 20260611 IS - 1873-7145 (Electronic) IS - 0963-9969 (Linking) VI - 188 DP - 2024 Jul TI - Profiling the novel plant-based meat alternative category: Consumer affective and sensory response in the context of perceived similarity to meat. PG - 114465 LID - S0963-9969(24)00535-0 [pii] LID - 10.1016/j.foodres.2024.114465 [doi] AB - Plant-based meat alternatives (PBMAs) are increasingly popular and may contribute towards reduction of negative environmental impacts associated with the meat industry. Inferior sensory characteristics of PBMAs, compared to conventional meat products, remain a barrier for uptake of these products. This study aimed to profile a wide range of PBMAs for perceived similarity to meat, consumer liking, emotional response and sensory experience, and to determine consumer drivers of liking for this product category. Twenty-one PBMAs, spanning a broad range of product types (burger patties, sausages, meatball alternatives, chicken/beef pieces, bacon alternative, turkey roast alternative) and main protein ingredients (extruded plant proteins, tofu, or legumes/vegetables) representative of PBMAs available to Aotearoa New Zealand consumers, were tasted and evaluated by 140 Aotearoa New Zealand residents. Samples ranged widely in their perceived similarity to meat (median value range: 1.0-4.0 on a 5-point-scale) and overall liking ratings (mean +/- SD, range: 35.1 +/- 1.2--77.7 +/- 17.4 on a 100-point hedonic scale). Overall liking ratings were driven mostly by liking for flavour, followed by texture, and less so by appearance. Sensorially, sample differentiation was mostly associated with variation in meat-related flavours and textures, or vegetable-related attributes. Notably meat flavour was the main driver of liking, and a very strong relationship (r = 0.92) was observed between perceived similarity to meat and overall sample liking ratings. Meat-like samples were also associated with positive emotional terms, whereas samples made from wholefoods were associated with negative emotional terms. Textural terms ('gluey/slimy', 'pasty/doughy') associated with wholefood products were also negative drivers for liking, and should be avoided in future PBMA products. In conclusion, the general population maintains a strong preference for PBMAs that are similar to meat, validating ongoing efforts to improve the meat-like properties of new and emerging products. PBMAs made from wholefoods require extensive product development to achieve consumer satisfaction across the category. CI - Copyright (c) 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Giezenaar, Caroline AU - Giezenaar C AD - Food Experience and Sensory Testing (Feast) Lab, School of Food and Advanced Technology, Massey University, Palmerston North 4410, New Zealand. FAU - Orr, Rebekah E AU - Orr RE AD - Food Experience and Sensory Testing (Feast) Lab, School of Food and Advanced Technology, Massey University, Palmerston North 4410, New Zealand. FAU - Godfrey, A Jonathan R AU - Godfrey AJR AD - Statistics Group, School of Mathematical and Computational Sciences, Massey University, Palmerston North, New Zealand. FAU - Maggs, Robyn AU - Maggs R AD - Food Experience and Sensory Testing (Feast) Lab, School of Food and Advanced Technology, Massey University, Palmerston North 4410, New Zealand. FAU - Foster, Meika AU - Foster M AD - Edible Research Limited, Ohoka 7475, New Zealand. FAU - Hort, Joanne AU - Hort J AD - Food Experience and Sensory Testing (Feast) Lab, School of Food and Advanced Technology, Massey University, Palmerston North 4410, New Zealand; Riddet Institute, Massey University, Palmerston North 4410, New Zealand. Electronic address: j.hort@massey.ac.nz. LA - eng PT - Journal Article DEP - 20240506 PL - Canada TA - Food Res Int JT - Food research international (Ottawa, Ont.) JID - 9210143 SB - IM EIN - Food Res Int. 2025 May;209:116325. doi: 10.1016/j.foodres.2025.116325. PMID: 40253214 MH - *Consumer Behavior MH - Humans MH - Adult MH - Male MH - Female MH - *Food Preferences MH - Middle Aged MH - *Taste MH - Young Adult MH - *Meat Products/analysis MH - New Zealand MH - Adolescent MH - Aged MH - Meat/analysis MH - Emotions MH - Meat Substitutes OTO - NOTNLM OT - Consumer study OT - Emotional response OT - Liking OT - Plant-based meat alternatives OT - Product acceptance OT - Sensory attributes COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/06/02 00:43 MHDA- 2024/06/02 00:44 CRDT- 2024/06/01 20:59 PHST- 2024/02/22 00:00 [received] PHST- 2024/04/24 00:00 [revised] PHST- 2024/05/01 00:00 [accepted] PHST- 2024/06/02 00:44 [medline] PHST- 2024/06/02 00:43 [pubmed] PHST- 2024/06/01 20:59 [entrez] AID - S0963-9969(24)00535-0 [pii] AID - 10.1016/j.foodres.2024.114465 [doi] PST - ppublish SO - Food Res Int. 2024 Jul;188:114465. doi: 10.1016/j.foodres.2024.114465. Epub 2024 May 6. PMID- 38822278 OWN - NLM STAT- MEDLINE DCOM- 20240601 LR - 20240603 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 24 IP - 1 DP - 2024 May 31 TI - Validity and reliability of the Swedish version of the Children's Sleep Habits Questionnaire (CSHQ-SWE). PG - 378 LID - 10.1186/s12887-024-04859-z [doi] LID - 378 AB - BACKGROUND: To translate and culturally adapt the Children's Sleep Habits Questionnaire (CSHQ) to a Swedish version, CSHQ-SWE, and to assess its validity and reliability for use with children with attention deficit hyperactivity disorder (ADHD). METHODS: A total of 84 children with ADHD (51 boys and 33 girls; 6-12 years) and parents (7 men and 77 women; 28-51 years) were included in the study. CSHQ was translated and culturally adapted to Swedish, and assessed for concurrent validity with sleep actigraphy (analyzed by Kendall's Tau) and for reliability by internal consistency (analyzed by McDonald's Omega H). Face and content validity was evaluated by parents (n = 4) and healthcare professionals (n = 6) qualitatively (comprehensiveness, relevance, and comprehensibility assessed by interviews and analyzed by thematic analysis) and quantitatively (analyzed by content validity ratio and content validity index for 33 items and four non-scored inquiries). RESULTS: Parent-reported sleep problems (CSHQ-SWE total score) were moderately correlated with less "Sleep Efficiency" (Tau = -0.305; p < 0.001) measured by sleep actigraphy. Parent-reported problems with "Sleep Onset Delay" was moderately correlated with measured time for "Sleep Onset Latency" (Tau = 0.433; p < 0.001). Parent-reported problems with "Night Wakings" were weakly correlated with measured time for "Wake After Sleep Onset" (Tau = 0.282; p < 0.001). Parents estimation of "Total daily sleep duration" was moderately correlated with measured "Total Sleep Time" (Tau = 0.386; p < 0.001). Five of the seven subscales reached an acceptable level for internal consistency (McDonald's Omega H > 0.700). Comprehensiveness, relevance, and comprehensibility of CSHQ-SWE were satisfactory overall. Content validity ratio was 0.80 to 1.00 for six items, 0.00 to 0.60 for 22 items, and < 0.00 for nine items. Content validity index was 0.22. CONCLUSIONS: CSHQ-SWE demonstrated acceptable concurrent validity with objectively measured sleep and internal consistency, whereas the overall results of face and content validity assessment varied. The instrument needs to be further evaluated regarding construct validity, responsiveness, test-retest reliability, and its generalization to other populations. CI - (c) 2024. The Author(s). FAU - Larsson, Ingrid AU - Larsson I AUID- ORCID: 0000-0002-4341-660X AD - School of Health and Welfare, Halmstad University, Box 823, Halmstad, SE-301 18, Sweden. FAU - Svedberg, Petra AU - Svedberg P AUID- ORCID: 0000-0003-4438-6673 AD - School of Health and Welfare, Halmstad University, Box 823, Halmstad, SE-301 18, Sweden. FAU - Nygren, Jens M AU - Nygren JM AUID- ORCID: 0000-0002-3576-2393 AD - School of Health and Welfare, Halmstad University, Box 823, Halmstad, SE-301 18, Sweden. FAU - Malmborg, Julia S AU - Malmborg JS AUID- ORCID: 0000-0001-9918-461X AD - School of Health and Welfare, Halmstad University, Box 823, Halmstad, SE-301 18, Sweden. julia.soderstrom_malmborg@hh.se. LA - eng PT - Journal Article PT - Validation Study DEP - 20240531 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Male MH - Female MH - Child MH - Reproducibility of Results MH - Sweden MH - Surveys and Questionnaires/standards MH - *Actigraphy MH - *Attention Deficit Disorder with Hyperactivity/diagnosis MH - Adult MH - *Parents MH - Middle Aged MH - Translations MH - Sleep MH - Habits MH - Sleep Wake Disorders/diagnosis/etiology PMC - PMC11140946 OTO - NOTNLM OT - ADHD OT - CSHQ OT - Children's sleep habits questionnaire OT - Reliability OT - Sleep OT - Sleep actigraphy OT - Validity COIS- The authors declare no competing interests. EDAT- 2024/06/01 10:50 MHDA- 2024/06/01 20:45 PMCR- 2024/05/31 CRDT- 2024/05/31 23:56 PHST- 2024/02/19 00:00 [received] PHST- 2024/05/27 00:00 [accepted] PHST- 2024/06/01 20:45 [medline] PHST- 2024/06/01 10:50 [pubmed] PHST- 2024/05/31 23:56 [entrez] PHST- 2024/05/31 00:00 [pmc-release] AID - 10.1186/s12887-024-04859-z [pii] AID - 4859 [pii] AID - 10.1186/s12887-024-04859-z [doi] PST - epublish SO - BMC Pediatr. 2024 May 31;24(1):378. doi: 10.1186/s12887-024-04859-z. PMID- 38822035 OWN - NLM STAT- MEDLINE DCOM- 20240531 LR - 20240603 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 May 31 TI - Painkiller intake and problematic health literacy in sport and music students - A cross-sectional study. PG - 12517 LID - 10.1038/s41598-024-63127-3 [doi] LID - 12517 AB - Previous works have suggested a high prevalence of painkiller intake (PI) among sport students but also improved health literacy (HL) for sports-active students than for sports-inactive students. Since health-related content also forms part of the sport science curriculum, the study focuses on these seemingly paradoxical results. Music students who are also physically active through their instrumental practice, who act in an area with increased PI and who have no health-related teaching content in their curriculum composed the comparison group. Therefore, this study investigated the prevalence of PI and HL in cohorts of sport (n = 222; 54.5% female) and music students (n = 89; 67.4% female) using a cross-sectional online survey in Lower Saxony, Germany. The hypothesis tests were validated by calculating frequentist and Bayesian statistics. The results show that 50.9% of sport and 28.1% of music students exhibit PI concerning their study programs, often for prophylactical purposes and in the presence of low HL levels. The weak negative correlation between PI and HL was not statistically confirmed and requires further research with improved test power. Regarding the possible health consequences of an inconsiderate PI, target group-specific prevention is indicated to increase general health awareness and HL. CI - (c) 2024. The Author(s). FAU - Poppel, Katharina AU - Poppel K AD - School IV - School of Humanities and Social Sciences, Carl von Ossietzky Universitat Oldenburg, Institute of Sport Science, Ammerlander Heerstrasse 114-118, 26129, Oldenburg, Germany. katharina.poeppel@uol.de. FAU - Kreutz, Gunter AU - Kreutz G AD - School III - School of Linguistics and Cultural Studies, Carl von Ossietzky Universitat Oldenburg, Institute of Music, Ammerlander Heerstrasse 114-118, 26129, Oldenburg, Germany. FAU - Muller, Maren AU - Muller M AD - School IV - School of Humanities and Social Sciences, Carl von Ossietzky Universitat Oldenburg, Institute of Sport Science, Ammerlander Heerstrasse 114-118, 26129, Oldenburg, Germany. FAU - Busch, Dirk AU - Busch D AD - School IV - School of Humanities and Social Sciences, Carl von Ossietzky Universitat Oldenburg, Institute of Sport Science, Ammerlander Heerstrasse 114-118, 26129, Oldenburg, Germany. LA - eng PT - Journal Article DEP - 20240531 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Health Literacy MH - Female MH - Male MH - Cross-Sectional Studies MH - *Students/psychology MH - *Music MH - Young Adult MH - Germany MH - *Sports MH - Adult MH - Adolescent MH - Surveys and Questionnaires PMC - PMC11143348 OTO - NOTNLM OT - Analgesics OT - Bayesian statistics OT - Online survey OT - University OT - Young adults COIS- The authors declare no competing interests. EDAT- 2024/06/01 10:51 MHDA- 2024/06/01 10:52 PMCR- 2024/05/31 CRDT- 2024/05/31 23:22 PHST- 2024/01/07 00:00 [received] PHST- 2024/05/24 00:00 [accepted] PHST- 2024/06/01 10:52 [medline] PHST- 2024/06/01 10:51 [pubmed] PHST- 2024/05/31 23:22 [entrez] PHST- 2024/05/31 00:00 [pmc-release] AID - 10.1038/s41598-024-63127-3 [pii] AID - 63127 [pii] AID - 10.1038/s41598-024-63127-3 [doi] PST - epublish SO - Sci Rep. 2024 May 31;14(1):12517. doi: 10.1038/s41598-024-63127-3. PMID- 38821458 OWN - NLM STAT- MEDLINE DCOM- 20240716 LR - 20260915 IS - 1096-0953 (Electronic) IS - 0013-9351 (Print) IS - 0013-9351 (Linking) VI - 257 DP - 2024 Sep 15 TI - Fish intake and mercury exposure in young children. PG - 119277 LID - S0013-9351(24)01182-4 [pii] LID - 10.1016/j.envres.2024.119277 [doi] AB - Fish consumption is one of the main sources of mercury (Hg) exposure, but few studies have examined Hg exposure from fish consumption among children. This study aimed to assess the frequency of fish intake and associations with Hg and other element concentrations among 700 three-year-old children from the New Hampshire Birth Cohort Study. Usual fish intake was derived from a validated food frequency questionnaire (Block Questionnaire for ages 2-7) and toenail element concentrations were determined using ICP-MS. Multiple linear regression analysis was used to assess the association between fish intake and toenail element concentrations. A mixture analysis, using Weighted quantile sum (WQS) regression, was used to estimate the relative contribution of fish consumption to element exposures. Twenty-three percent of children were reported to consume at least one fish meal/week on average during the previous 6 months. In adjusted linear regression models, children with any type of fish consumption versus no consumption had 108% (95% confidence interval (CI: 68%, 153%)) higher toenail Hg concentrations. To a lesser extent, children consuming "other fish (not fried) including tuna" and "fried fish or fish sticks" had 120% (95% CI: 82%, 164%), and 23% (95% CI: 2%, 51%) higher toenail concentrations, respectively, than those consuming no fish. Using WQS regression, Hg was the element most strongly related to fish consumption. Fish intake among young children was related to Hg exposure even at low levels of consumption. Future studies will need to determine the health consequences of this exposure. CI - Copyright (c) 2024 Elsevier Inc. All rights reserved. FAU - Notario Barandiaran, Leyre AU - Notario Barandiaran L AD - Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, 03755, USA. Electronic address: leyre.notario.barandiaran@dartmouth.edu. FAU - Bauer, Julia A AU - Bauer JA AD - Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, IL, 60612, USA. FAU - Jackson, Brian P AU - Jackson BP AD - Trace Element Analysis Laboratory, Earth Sciences, Dartmouth College, Hanover, NH, 03755, USA. FAU - Karagas, Margaret R AU - Karagas MR AD - Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, 03755, USA. LA - eng GR - UH3 OD023275/OD/NIH HHS/United States GR - P42 ES007373/ES/NIEHS NIH HHS/United States GR - P30 CA023108/CA/NCI NIH HHS/United States GR - T32 CA134286/CA/NCI NIH HHS/United States GR - R25 CA134286/CA/NCI NIH HHS/United States GR - P30 GM149408/GM/NIGMS NIH HHS/United States GR - P01 ES022832/ES/NIEHS NIH HHS/United States GR - P30 ES027792/ES/NIEHS NIH HHS/United States PT - Journal Article DEP - 20240529 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - FXS1BY2PGL (Mercury) SB - IM MH - Humans MH - *Mercury/analysis MH - Child, Preschool MH - *Nails/chemistry MH - Female MH - Male MH - Animals MH - *Fishes MH - Food Contamination/analysis MH - Seafood/analysis MH - New Hampshire MH - Environmental Exposure/analysis MH - Diet/statistics & numerical data MH - Dietary Exposure/analysis MH - Cohort Studies PMC - PMC11251838 MID - NIHMS2001160 OTO - NOTNLM OT - Fish intake OT - Infancy OT - Mercury OT - Methylmercury COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Margaret R. Karagas reports financial support was provided by National Institutes of Health. Julia A. Bauer reports financial support was provided by National Institutes of Health. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/06/01 10:51 MHDA- 2024/07/17 05:43 PMCR- 2025/09/15 CRDT- 2024/05/31 19:23 PHST- 2024/03/08 00:00 [received] PHST- 2024/05/24 00:00 [revised] PHST- 2024/05/28 00:00 [accepted] PHST- 2024/07/17 05:43 [medline] PHST- 2024/06/01 10:51 [pubmed] PHST- 2024/05/31 19:23 [entrez] PHST- 2025/09/15 00:00 [pmc-release] AID - S0013-9351(24)01182-4 [pii] AID - 10.1016/j.envres.2024.119277 [doi] PST - ppublish SO - Environ Res. 2024 Sep 15;257:119277. doi: 10.1016/j.envres.2024.119277. Epub 2024 May 29. PMID- 38821266 OWN - NLM STAT- MEDLINE DCOM- 20240705 LR - 20240923 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 200 DP - 2024 Sep 1 TI - "I find it hard to change poor food habits": Measuring food choice motives in an emerging economy. PG - 107535 LID - S0195-6663(24)00338-6 [pii] LID - 10.1016/j.appet.2024.107535 [doi] AB - Food choices are driven by an array of motives that have been approached, determined and quantified in a number of ways, mainly in developed countries. The objective of this study was to better understand the motives behind food choices in an emerging economy by collecting information from urban people in South Africa in a series of four studies. (1) Items generated through focus group discussions with low, middle and high income participants by Magano et al. (2023) were checked for content and face validity and (2) 123 statements derived from them were evaluated by 621 respondents. After exploratory factor analysis (EFA), 46 statements best representing the motivational space were (3) presented to another group of respondents (n = 259). Here, the EFA resulted in a 31-item, 7-factor food choice questionnaire for emerging economies (FCQ-EE) which was (4) confirmed by a nationwide sample (n = 814) and further refined to an alternative 19-item, 7-factor solution. The emerging factors were: Healthy eating constraints (HEC), Frugality (FR), Emotional eating (EE), Meat appeal (MA), Weather (WE), Quality seeking (QS) and Cooking constraints (CC). Whether used in the 31-item or 19-item format, this set of statements highlights factors underlying food choice in an emerging economy and offers a way to study their importance in similar contexts. Further research is needed to show the extent to which these factors can predict actual food choices. CI - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Dlamini, Nomzamo N AU - Dlamini NN AD - Department of Consumer and Food Sciences, University of Pretoria, South Africa. Electronic address: u13034929@tuks.co.za. FAU - Ramkilawon, Gopika AU - Ramkilawon G AD - Department of Statistics, University of Pretoria, South Africa. FAU - Tuorila, Hely AU - Tuorila H AD - Department of Consumer and Food Sciences, University of Pretoria, South Africa; Department of Food and Nutrition, University of Helsinki, Finland. FAU - de Kock, Henrietta L AU - de Kock HL AD - Department of Consumer and Food Sciences, University of Pretoria, South Africa. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240529 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - *Food Preferences/psychology MH - Female MH - Male MH - *Motivation MH - Adult MH - South Africa MH - *Choice Behavior MH - Surveys and Questionnaires MH - Middle Aged MH - Young Adult MH - Feeding Behavior/psychology MH - Diet, Healthy/psychology/economics MH - Focus Groups MH - Adolescent MH - Factor Analysis, Statistical MH - Urban Population OTO - NOTNLM OT - Emerging economy OT - Food choice drivers OT - Food choice motives OT - Low-middle income country OT - Questionnaire development COIS- Declaration of Competing interest The manuscript contains original thoughts of the authors, which have not been published anywhere. We declare that no known conflict of interests associated with the publication that could have influenced the work reported in this paper. We confirm that the manuscript has been read and approved by all authors for submission. EDAT- 2024/06/01 10:51 MHDA- 2024/07/06 10:44 CRDT- 2024/05/31 19:20 PHST- 2023/11/26 00:00 [received] PHST- 2024/05/08 00:00 [revised] PHST- 2024/05/28 00:00 [accepted] PHST- 2024/07/06 10:44 [medline] PHST- 2024/06/01 10:51 [pubmed] PHST- 2024/05/31 19:20 [entrez] AID - S0195-6663(24)00338-6 [pii] AID - 10.1016/j.appet.2024.107535 [doi] PST - ppublish SO - Appetite. 2024 Sep 1;200:107535. doi: 10.1016/j.appet.2024.107535. Epub 2024 May 29. PMID- 38820601 OWN - NLM STAT- MEDLINE DCOM- 20241001 LR - 20241001 IS - 1715-5320 (Electronic) IS - 1715-5312 (Linking) VI - 49 IP - 10 DP - 2024 Oct 1 TI - Construct validity and reliability of a French-Canadian translation of the eating in the absence of hunger questionnaire for children and adolescents. PG - 1309-1316 LID - 10.1139/apnm-2023-0609 [doi] AB - Eating in the absence of hunger (EAH) has been associated with overweight and obesity during childhood. The gold standard to assess this behavior is a laboratory-based protocol, but a questionnaire to assess EAH more efficiently in children and adolescents has been developed and validated in English. We assessed construct validity (structural and convergent validity) and reliability (internal consistency and temporal stability) of a French translation of the EAH Questionnaire for Children and Adolescents among French-Canadian youths. We recruited participants in Montreal (Canada) aged 7-15 years old, who completed the questionnaire and provided anthropometric data. We asked participants to complete the questionnaire a second time approximately 4 weeks later. The questionnaire consists of 14 questions and 3 subscales that assess EAH due to negative affect, fatigue/boredom, and external cues. We performed an exploratory factor analysis to test the factor structure and we calculated Cronbach alpha coefficients and intra-class correlations to assess internal consistency and temporal stability, respectively. We assessed associations between EAH and BMI z-score using Pearson correlations. We included 196 participants (50% girls; mean (SD) 11.9 (2.3) years old) for the first completion and 153 for the second completion. The exploratory factor analysis generated the same three subscales as the original questionnaire: negative affect (alpha = 0.86; ICC = 0.78), fatigue/boredom (alpha = 0.75; ICC = 0.70), and external cues (alpha = 0.68; ICC = 0.54). Participant's BMI z-scores were positively associated with the average scores from the negative affect subscale (r = 0.19; rho = 0.009). Our results suggest that this questionnaire has an adequate construct validity, internal consistency, and temporal stability. FAU - Savard, C AU - Savard C AD - Department of Nutrition, Universite de Montreal, Montreal, QC H3T 1A8, Canada. RINGGOLD: 5622 AD - Sainte-Justine University Hospital Research Centre, Montreal, QC H3T 1C5, Canada. FAU - Begin, S AU - Begin S AD - Sainte-Justine University Hospital Research Centre, Montreal, QC H3T 1C5, Canada. FAU - Robitaille, J AU - Robitaille J AD - School of Nutrition, Universite Laval, Quebec, QC G1V 0A6, Canada. AD - Centre de recherche Nutrition sante et societe (NUTRISS), Institut sur la nutrition et les aliments fonctionnels (INAF), Universite Laval, Quebec, QC G1V 0A6, Canada. FAU - Hivert, M-F AU - Hivert MF AD - Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA 02215, US. FAU - Parent, S AU - Parent S AD - Sainte-Justine University Hospital Research Centre, Montreal, QC H3T 1C5, Canada. AD - Department of Surgery, Universite de Montreal, Montreal, QC H3T 1J4, Canada. FAU - Gingras, V AU - Gingras V AUID- ORCID: 0000-0003-4918-7534 AD - Department of Nutrition, Universite de Montreal, Montreal, QC H3T 1A8, Canada. RINGGOLD: 5622 AD - Sainte-Justine University Hospital Research Centre, Montreal, QC H3T 1C5, Canada. LA - eng PT - Journal Article PT - Validation Study DEP - 20240531 PL - Canada TA - Appl Physiol Nutr Metab JT - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme JID - 101264333 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - Adolescent MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - *Hunger MH - Translations MH - Feeding Behavior MH - Body Mass Index MH - Quebec MH - Canada OTO - NOTNLM OT - behavioural nutrition OT - eating in the absence of hunger OT - nutrition OT - obesity OT - pediatrics OT - questionnaire validation COIS- The authors declare no competing interests. EDAT- 2024/05/31 18:42 MHDA- 2024/10/03 03:27 CRDT- 2024/05/31 17:42 PHST- 2024/10/03 03:27 [medline] PHST- 2024/05/31 18:42 [pubmed] PHST- 2024/05/31 17:42 [entrez] AID - 10.1139/apnm-2023-0609 [doi] PST - ppublish SO - Appl Physiol Nutr Metab. 2024 Oct 1;49(10):1309-1316. doi: 10.1139/apnm-2023-0609. Epub 2024 May 31. PMID- 38820512 OWN - NLM STAT- MEDLINE DCOM- 20240531 LR - 20260805 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 5 DP - 2024 TI - Analysis of urinary tobacco-specific nitrosamine 4- (methylnitrosamino)1-(3-pyridyl)-1- butanol (NNAL) and HPV infection in American women: National health and nutrition examination survey. PG - e0304499 LID - 10.1371/journal.pone.0304499 [doi] LID - e0304499 AB - Tobacco-specific nitrosamines (TSNAs) are a group of toxic substances specific to tobacco. 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is a tobacco-specific nitrosamine measurable in urine with a much longer half-life than cotinine. We aimed to examine the association between urinary tobacco-specific NNAL and HPV infection among American women. We used cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2014 to collect details on their urinary NNAL, HPV infection status, and other essential variables. The association between dietary urinary NNAL and HPV infection status was analyzed by using a weighted multivariate logistic regression model, and stratified subgroup analysis. In total, 5197 participants aged 18-59 years were identified, with overall prevalence of high-risk and low-risk HPV infection of 22.0% and 19.1%, respectively. The highest quartile of NNAL(Q4) was more positively associated with low-risk HPV infection than the lowest quartile of NNAL(Q1) (OR = 1.83 (1.35,2.50), p<0.001). the highest quartile of NNAL(Q4) was more positively associated with high-risk HPV infection than the lowest quartile of NNAL(Q1) (OR = 2.20 (1.57,3.08), p < 0.001). In subgroup analyses, the positive correlation between urinary NNAL levels and low-risk HPV infection status was inconsistent in marital status and BMI (interaction p < 0.05). The positive association of urinary NNAL levels with high-risk HPV infection status was inconsistent in smoking and BMI. (interaction p < 0.05). Tobacco-specific NNAL levels positively correlate with high- and low-risk HPV. Future well-designed longitudinal studies are still needed to validate the effect of tobacco exposure on HPV infection by NNAL. CI - Copyright: (c) 2024 Liang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Liang, Daiwen AU - Liang D AD - Department of Dermatology and Venereology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. FAU - Zhang, Qi AU - Zhang Q AD - Department of Dermatology and Venereology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. FAU - Li, Wenyu AU - Li W AD - Department of Dermatology and Venereology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. FAU - Lin, Youkun AU - Lin Y AUID- ORCID: 0000-0001-5487-0245 AD - Department of Dermatology and Venereology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. LA - eng PT - Journal Article DEP - 20240531 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Nitrosamines) RN - EN7PIX794W (4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol) RN - 0 (Pyridines) SB - IM MH - Humans MH - Female MH - *Nitrosamines/urine MH - Adult MH - *Papillomavirus Infections/urine/epidemiology/virology MH - Middle Aged MH - Adolescent MH - Young Adult MH - *Nutrition Surveys MH - Cross-Sectional Studies MH - United States/epidemiology MH - *Pyridines/urine MH - Prevalence MH - Nicotiana PMC - PMC11142655 COIS- the authors have declared that no competing interests exist. EDAT- 2024/05/31 18:42 MHDA- 2024/05/31 18:43 PMCR- 2024/05/31 CRDT- 2024/05/31 16:13 PHST- 2024/03/11 00:00 [received] PHST- 2024/05/13 00:00 [accepted] PHST- 2024/05/31 18:43 [medline] PHST- 2024/05/31 18:42 [pubmed] PHST- 2024/05/31 16:13 [entrez] PHST- 2024/05/31 00:00 [pmc-release] AID - PONE-D-24-07713 [pii] AID - 10.1371/journal.pone.0304499 [doi] PST - epublish SO - PLoS One. 2024 May 31;19(5):e0304499. doi: 10.1371/journal.pone.0304499. eCollection 2024. PMID- 38819432 OWN - NLM STAT- MEDLINE DCOM- 20240531 LR - 20260810 IS - 2045-7634 (Electronic) IS - 2045-7634 (Linking) VI - 13 IP - 11 DP - 2024 Jun TI - Prevalence and biopsychosocial indicators of fatigue in cancer patients. PG - e7293 LID - 10.1002/cam4.7293 [doi] LID - e7293 AB - INTRODUCTION: Symptoms of cancer-related fatigue (CRF) can have a significant impact on patients' quality of life and treatment adherence. We aimed to investigate the relationship between CRF and multiple psychosocial and somatic indicators within a large mixed cancer sample. METHODS: In this cross-sectional study, N = 1787 outpatients with cancer were assessed for CRF, pain, anxiety, and depression using validated screening instruments. We further obtained clinical parameters (Hb, CRP, creatinine, leukocytes, ASAT, and ALAT), sociodemographic data (age, gender, income, education level, marital status, parenthood, and living area), and lifestyle factors. Multivariate linear regression models were applied to estimate the impact of each indicator on CRF. RESULTS: Overall, 90.6% of patients experienced some CRF, with 14.8% experiencing severe CRF. No gender difference was found in the prevalence of CRF. Patients with higher levels of pain, depressive symptoms, and lower Hb levels had significantly higher levels of CRF (p(s) <0.001). Lower levels of CRF were observed in patients who had children (p = 0.03), had less education (p < 0.001), and were physically active for more than 2 h per week before their oncological diagnosis (p = 0.014). The latter was only a significant indicator in the male subsample. CONCLUSION: The present results demonstrate a high prevalence of CRF and highlight that not only somatic and psychosocial factors, but also lifestyle factors prior to diagnosis appear to be associated with the etiology and persistence of CRF. To effectively treat CRF, a biopsychosocial, personalized approach is recommended. CI - (c) 2024 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd. FAU - Zeilinger, Elisabeth L AU - Zeilinger EL AUID- ORCID: 0000-0002-0625-500X AD - Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria. AD - Department of Clinical Research SBG, Academy for Ageing Research, Haus der Barmherzigkeit, Vienna, Austria. AD - Department of Clinical and Health Psychology, Faculty of Psychology, University of Vienna, Vienna, Austria. FAU - Zrnic-Novakovic, Irina AU - Zrnic-Novakovic I AD - Department of Clinical and Health Psychology, Faculty of Psychology, University of Vienna, Vienna, Austria. FAU - Oppenauer, Claudia AU - Oppenauer C AD - Division of Clinical Psychology, Department of Psychology and Psychodynamics, Karl Landsteiner University of Health Sciences, Krems, Austria. FAU - Fellinger, Matthaus AU - Fellinger M AD - Clinical Division of Social Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria. AD - Second Department of Psychiatry and Psychotherapy, Clinic Hietzing, Vienna Healthcare Group, Vienna, Austria. FAU - Knefel, Matthias AU - Knefel M AUID- ORCID: 0000-0003-0632-0673 AD - Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria. AD - Department of Internal Medicine, Landesklinikum Baden-Modling, Baden, Austria. FAU - Unseld, Matthias AU - Unseld M AD - Department of Clinical Research SBG, Academy for Ageing Research, Haus der Barmherzigkeit, Vienna, Austria. FAU - Wagner, Theresa AU - Wagner T AD - Department of Clinical and Health Psychology, Faculty of Psychology, University of Vienna, Vienna, Austria. FAU - Lubowitzki, Simone AU - Lubowitzki S AD - Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria. FAU - Bartsch, Rupert AU - Bartsch R AD - Division of Oncology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria. FAU - Zochbauer-Muller, Sabine AU - Zochbauer-Muller S AD - Division of Oncology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria. FAU - Raderer, Markus AU - Raderer M AD - Division of Oncology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria. FAU - Staber, Philipp B AU - Staber PB AD - Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria. FAU - Valent, Peter AU - Valent P AD - Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria. AD - Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria. FAU - Gaiger, Alexander AU - Gaiger A AD - Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria. AD - Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria. LA - eng PT - Journal Article PL - United States TA - Cancer Med JT - Cancer medicine JID - 101595310 SB - IM MH - Humans MH - Male MH - Female MH - *Neoplasms/complications/psychology/epidemiology MH - *Fatigue/epidemiology/etiology/psychology MH - Middle Aged MH - Cross-Sectional Studies MH - Prevalence MH - Aged MH - *Depression/epidemiology/etiology MH - *Quality of Life MH - Adult MH - Anxiety/epidemiology PMC - PMC11141333 OTO - NOTNLM OT - biopsychosocial models OT - fatigue OT - mental health OT - neoplasms OT - psycho-oncology COIS- Rupert Bartsch: Consulting fees: Astra-Zeneca, Daiichi, Eisai, Eli-Lilly, Gilead, Gruenenthal, MSD, Novartis, Pfizer, Pierre-Fabre, Puma, Roche, Seagen. Lecture Honoraria: Astra-Zeneca, Daichi, Eisai, Eli-Lilly, Gilead, Gruenenthal, MSD, Novartis, Pfizer, Pierre-Fabre, Roche, Seagen. Support for attending meetings and/or travel: AstraZeneca, Daiichi, MSD, Roche. Peter Valent: Consulting fees: Novartis, Blueprint, BMS/Celgene, Pfizer, Cogent, and AOP Orphan. All other authors have nothing to disclose. EDAT- 2024/05/31 12:43 MHDA- 2024/05/31 12:44 PMCR- 2024/05/31 CRDT- 2024/05/31 10:54 PHST- 2024/04/29 00:00 [revised] PHST- 2024/01/08 00:00 [received] PHST- 2024/05/05 00:00 [accepted] PHST- 2024/05/31 12:44 [medline] PHST- 2024/05/31 12:43 [pubmed] PHST- 2024/05/31 10:54 [entrez] PHST- 2024/05/31 00:00 [pmc-release] AID - CAM47293 [pii] AID - 10.1002/cam4.7293 [doi] PST - ppublish SO - Cancer Med. 2024 Jun;13(11):e7293. doi: 10.1002/cam4.7293. PMID- 38817706 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240601 IS - 2475-2991 (Electronic) IS - 2475-2991 (Linking) VI - 8 IP - 6 DP - 2024 Jun TI - Feasibility of Using an Artificial Intelligence-based Telephone Application for Dietary Assessment and Nudging to Improve the Quality of Food Choices of Female Adolescents in Vietnam: Evidence from a Randomized Pilot Study. PG - 102063 LID - 10.1016/j.cdnut.2023.102063 [doi] LID - 102063 AB - BACKGROUND: Adolescent nutrition has faced a policy neglect, partly owing to the gaps in dietary intake data for this age group. The Food Recognition Assistance and Nudging Insights (FRANI) is a smartphone application validated for dietary assessment and to influence users toward healthy food choices. OBJECTIVES: This study aimed to assess the feasibility (adherence, acceptability, and usability) of FRANI and its effects on food choices and diet quality in female adolescents in Vietnam. METHODS: Adolescents (N = 36) were randomly selected from a public school and allocated into 2 groups. The control group received smartphones with a version of FRANI limited to dietary assessment, whereas the intervention received smartphones with gamified FRANI. After the first 4 wk, both groups used gamified FRANI for further 2 wk. The primary outcome was the feasibility of using FRANI as measured by adherence (the proportion of completed food records), acceptability and usability (the proportion of participants who considered FRANI acceptable and usable according to answers of a Likert questionnaire). Secondary outcomes included the percentage of meals recorded, the Minimum Dietary Diversity for Women (MDDW) and the Eat-Lancet Diet Score (ELDS). Dietary diversity is important for dietary quality, and sustainable healthy diets are important to reduce carbon emissions. Poisson regression models were used to estimate the effect of gamified FRANI on the MDDW and ELDS. RESULTS: Adherence to the application was 82% and the percentage of meals recorded was 97%. Acceptability and usability were 97%. MDDW in the intervention group was 1.07 points (95% CI: 0.98, 1.18; P = 0.13) greater than that in the control (constant = 4.68); however, the difference was not statistically significant. Moreover, ELDS in the intervention was 1.09 (95% CI: 1.01, 1.18; P = 0.03) points greater than in the control (constant = 3.67). CONCLUSIONS: FRANI was feasible and may be effective to influence users toward healthy food choices. Research is needed for FRANI in different contexts and at scale.The trial was registered at the International Standard Randomized Controlled Trial Number as ISRCTN 10681553. CI - (c) 2023 The Authors. FAU - Braga, Bianca C AU - Braga BC AD - Friedman School of Nutrition Policy and Science, Tufts University, Boston, MA, United States. FAU - Nguyen, Phuong H AU - Nguyen PH AD - Nutrition, Health and Diet, International Food Policy Research Institute, Washington, DC, United States. AD - Thai Nguyen University of Pharmacy and Medicine, Thai Nguyen, Vietnam. FAU - Tran, Lan Mai AU - Tran LM AD - Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States. FAU - Hoang, Nga Thu AU - Hoang NT AD - National Institute of Nutrition, Hanoi, Vietnam. FAU - Bannerman, Boateng AU - Bannerman B AD - Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana. FAU - Doyle, Frank AU - Doyle F AD - College of Agricultural Sciences, Pennsylvania State University, State College, PA, United States. FAU - Folson, Gloria AU - Folson G AD - Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana. FAU - Gangupantulu, Rohit AU - Gangupantulu R AD - College of Agricultural Sciences, Pennsylvania State University, State College, PA, United States. FAU - Karachiwalla, Naureen AU - Karachiwalla N AD - Nutrition, Health and Diet, International Food Policy Research Institute, Washington, DC, United States. FAU - Kolt, Bastien AU - Kolt B AD - Nutrition, Health and Diet, International Food Policy Research Institute, Washington, DC, United States. FAU - McCloskey, Peter AU - McCloskey P AD - College of Agricultural Sciences, Pennsylvania State University, State College, PA, United States. FAU - Palloni, Giordano AU - Palloni G AD - Nutrition, Health and Diet, International Food Policy Research Institute, Washington, DC, United States. FAU - Thi Tran, Trang Huyen AU - Thi Tran TH AD - Thai Nguyen University of Pharmacy and Medicine, Thai Nguyen, Vietnam. FAU - Thuy Thi Troung, Duong AU - Thuy Thi Troung D AD - Thai Nguyen University of Pharmacy and Medicine, Thai Nguyen, Vietnam. FAU - Hughes, David AU - Hughes D AD - College of Agricultural Sciences, Pennsylvania State University, State College, PA, United States. FAU - Gelli, Aulo AU - Gelli A AD - Nutrition, Health and Diet, International Food Policy Research Institute, Washington, DC, United States. LA - eng PT - Journal Article DEP - 20231213 PL - United States TA - Curr Dev Nutr JT - Current developments in nutrition JID - 101717957 PMC - PMC11137395 OTO - NOTNLM OT - adolescence OT - artificial intelligence OT - dietary assessment OT - dietary intake OT - dietary quality OT - e-health OT - feasibility OT - m-health OT - randomized controlled trial OT - telephone application EDAT- 2024/05/31 06:42 MHDA- 2024/05/31 06:43 PMCR- 2023/12/13 CRDT- 2024/05/31 03:50 PHST- 2023/11/15 00:00 [received] PHST- 2023/12/04 00:00 [revised] PHST- 2023/12/08 00:00 [accepted] PHST- 2024/05/31 06:43 [medline] PHST- 2024/05/31 06:42 [pubmed] PHST- 2024/05/31 03:50 [entrez] PHST- 2023/12/13 00:00 [pmc-release] AID - S2475-2991(23)26647-0 [pii] AID - 102063 [pii] AID - 10.1016/j.cdnut.2023.102063 [doi] PST - epublish SO - Curr Dev Nutr. 2023 Dec 13;8(6):102063. doi: 10.1016/j.cdnut.2023.102063. eCollection 2024 Jun. PMID- 38812659 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240531 IS - 2509-3150 (Electronic) IS - 2509-3142 (Print) IS - 2509-3150 (Linking) VI - 54 IP - 2 DP - 2024 TI - The role of leisure-time physical activity in youth for lifelong activity-a latent profile analysis with retrospective life course data. PG - 192-200 LID - 10.1007/s12662-023-00884-9 [doi] AB - Considering the positive health effects of leisure-time physical activity (LTPA), youth is an important life stage to promote lifelong LTPA. However, the stability of LTPA over the life course is low, and specific predictors of LTPA in youth for lifelong activity have some shortcomings, e.g. neglecting the interacting factors of LTPA within individuals. Therefore, from a person-oriented approach, patterns of LTPA behaviour in youth considering time- and context-related aspects and their relationships with lifelong LTPA were investigated. Life course data from n = 1519 Swiss inhabitants aged between 25 and 76 years were recorded retrospectively using a validated questionnaire (CATI method). Latent profile analyses were used to find the optimal profile solution and for the association with lifelong LTPA auxiliary conditional effect models (controlled for age) were applied. Six distinct patterns emerged. Overall, mostly inactive youth are also the least active in adulthood, whereas several other patterns are associated with a mainly continuous LTPA throughout adulthood. More precisely, multiple constellations in youth occurred to be physically active in at least 80% of the years in adulthood: (1) early starters regarding LTPA in a rather self-organised setting but not with many different LTPAs; (2) late entrants with a variety of different activities and organisational settings; or (3) a high expression in every variable investigated. Consequently, there is not just one type of LTPA behaviour in youth linked to lifelong activity, which indicates that certain aspects of LTPA in youth can be compensated by each other. Implications for LTPA promotion can be derived. SUPPLEMENTARY INFORMATION: The online version of this article (10.1007/s12662-023-00884-9) contains supplementary material, which is available to authorized users. CI - (c) The Author(s) 2023. FAU - Lenze, Lars AU - Lenze L AUID- ORCID: 0000-0001-7610-8913 AD - Institute of Sport Science, University of Bern, Bremgartenstrasse 145, 3012 Bern, Switzerland. ROR: https://ror.org/02k7v4d05. GRID: grid.5734.5. ISNI: 0000 0001 0726 5157 AD - University of Teacher Education, University of Applied Sciences and Arts Northwestern Switzerland, 5210 Windisch, Switzerland. GRID: grid.410380.e. ISNI: 0000 0001 1497 8091 FAU - Klostermann, Claudia AU - Klostermann C AD - University of Teacher Education, University of Applied Sciences and Arts Northwestern Switzerland, 5210 Windisch, Switzerland. GRID: grid.410380.e. ISNI: 0000 0001 1497 8091 FAU - Schmid, Julia AU - Schmid J AD - Institute of Sport Science, University of Bern, Bremgartenstrasse 145, 3012 Bern, Switzerland. ROR: https://ror.org/02k7v4d05. GRID: grid.5734.5. ISNI: 0000 0001 0726 5157 FAU - Lamprecht, Markus AU - Lamprecht M AD - Lamprecht und Stamm Sozialforschung und Beratung, 8032 Zurich, Switzerland. ROR: https://ror.org/035881909. GRID: grid.483025.8 FAU - Nagel, Siegfried AU - Nagel S AD - Institute of Sport Science, University of Bern, Bremgartenstrasse 145, 3012 Bern, Switzerland. ROR: https://ror.org/02k7v4d05. GRID: grid.5734.5. ISNI: 0000 0001 0726 5157 LA - eng PT - Journal Article DEP - 20230526 PL - Germany TA - Ger J Exerc Sport Res JT - German journal of exercise and sport research JID - 101702025 PMC - PMC11135187 OTO - NOTNLM OT - Pattern OT - Person-oriented approach OT - Sport participation OT - Time-related and context-related aspects OT - Youth development COIS- Conflict of interestL. Lenze, C. Klostermann, J. Schmid, M. Lamprecht and S. Nagel declare that they have no competing interests. EDAT- 2024/05/30 06:35 MHDA- 2024/05/30 06:36 PMCR- 2023/05/26 CRDT- 2024/05/30 03:46 PHST- 2022/10/06 00:00 [received] PHST- 2023/03/21 00:00 [accepted] PHST- 2024/05/30 06:36 [medline] PHST- 2024/05/30 06:35 [pubmed] PHST- 2024/05/30 03:46 [entrez] PHST- 2023/05/26 00:00 [pmc-release] AID - 884 [pii] AID - 10.1007/s12662-023-00884-9 [doi] PST - ppublish SO - Ger J Exerc Sport Res. 2024;54(2):192-200. doi: 10.1007/s12662-023-00884-9. Epub 2023 May 26. PMID- 38812438 OWN - NLM STAT- MEDLINE DCOM- 20240807 LR - 20260720 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 27 IP - 1 DP - 2024 May 30 TI - Investigation of the psychometric properties of the Comprehensive Feeding Practices Questionnaire in Turkish parents. PG - e148 LID - 10.1017/S1368980024001125 [doi] LID - e148 AB - OBJECTIVE: The Comprehensive Feeding Practices Questionnaire (CFPQ) measures parental attitudes towards feeding practices that directly influence children's eating habits. This study aims to determine the reliability and validity of the Turkish adaptation of the CFPQ developed by Musher-Eizenman et al. DESIGN: Validity and reliability analyses were conducted for the Turkish version of the CFPQ (T-CFPQ). In addition to reliability analyses and partial correlations between scale dimensions, correlations between scale dimensions according to mothers' BMI and children's BMI z-scores were also examined. SETTING: Parents with children aged 18 months to 8 years living in the community. PARTICIPANTS: The study sample consisted of 274 parents with children aged 18 months to 8 years who agreed to participate in the online survey. RESULTS: In this study, forty-seven items and twelve-factor structure describing feeding practices were supported by the confirmatory factor analysis. Although most of the dimensions of the T-CFPQ showed significant correlations with each other, the highest correlation was found between the encourage balance/variety and the dimension of modelling and teaching nutrition (r = 0.53; 0.50) (P < 0.05). There was a negative correlation between the child's BMI z-score and the pressure to eat dimension (r = -0.173; P < 0.01) and a positive correlation between the restriction for weight dimension (r = 0.339; P < 0.01). Maternal BMI was negatively associated with the involvement dimension (r = -0.121; P < 0.05) and positively associated with the restriction for weight dimension (r = 0.154; P < 0.01). CONCLUSIONS: The findings revealed that the T-CFPQ is a valid and reliable measurement tool that can be applied to obtain the necessary information for evaluating nutritional interactions between parent and child. FAU - Sarahman-Kahraman, Ceren AU - Sarahman-Kahraman C AUID- ORCID: 0000-0002-6394-8101 AD - Department of Nutrition and Dietetics, University of Alanya Alaaddin Keykubat, Alanya/Antalya, Turkey. FAU - Memic-Inan, Cansu AU - Memic-Inan C AD - Department of Nutrition and Dietetics, Nigde Omer Halisdemir University, Nigde, Turkey. FAU - Yabanci-Ayhan, Nurcan AU - Yabanci-Ayhan N AD - Department of Nutrition and Dietetics, University of Ankara, Ankara, Turkey. FAU - Ozcelik, Ayse Ozfer AU - Ozcelik AO AD - Department of Nutrition and Dietetics, University of Ankara, Ankara, Turkey. LA - eng PT - Journal Article PT - Validation Study DEP - 20240530 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Turkey MH - Female MH - *Psychometrics MH - Male MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - *Feeding Behavior/psychology MH - Child MH - Adult MH - Child, Preschool MH - *Parents/psychology MH - Infant MH - Body Mass Index MH - Factor Analysis, Statistical MH - Mothers/psychology PMC - PMC11617419 OTO - NOTNLM OT - Child nutrition OT - Children's eating behaviours OT - Children's eating scale OT - Feeding practices OT - Parent-child relations COIS- All authors declare that they have no conflicts of interest. EDAT- 2024/05/30 06:35 MHDA- 2024/08/07 06:41 PMCR- 2024/05/30 CRDT- 2024/05/30 03:13 PHST- 2024/08/07 06:41 [medline] PHST- 2024/05/30 06:35 [pubmed] PHST- 2024/05/30 03:13 [entrez] PHST- 2024/05/30 00:00 [pmc-release] AID - S1368980024001125 [pii] AID - 10.1017/S1368980024001125 [doi] PST - epublish SO - Public Health Nutr. 2024 May 30;27(1):e148. doi: 10.1017/S1368980024001125. PMID- 38811916 OWN - NLM STAT- MEDLINE DCOM- 20240530 LR - 20260127 IS - 1471-244X (Electronic) IS - 1471-244X (Linking) VI - 24 IP - 1 DP - 2024 May 29 TI - The association between maximal muscle strength, disease severity and psychopharmacotherapy among young to middle-aged inpatients with affective disorders - a prospective pilot study. PG - 401 LID - 10.1186/s12888-024-05849-2 [doi] LID - 401 AB - BACKGROUND: Motor alterations and lowered physical activity are common in affective disorders. Previous research has indicated a link between depressive symptoms and declining muscle strength primarily focusing on the elderly but not younger individuals. Thus, we aimed to evaluate the relationship between mood and muscle strength in a sample of N = 73 young to middle-aged hospitalized patients (18-49 years, mean age 30.7 years) diagnosed with major depressive, bipolar and schizoaffective disorder, with a focus on moderating effects of psychopharmacotherapy. The study was carried out as a prospective observational study at a German psychiatric university hospital between September 2021 and March 2022. METHODS: Employing a standardized strength circuit consisting of computerized strength training devices, we measured the maximal muscle strength (F(max)) using three repetitions maximum across four muscle regions (abdomen, arm, back, leg) at three time points (t(1)-t(3)) over four weeks accompanied by psychometric testing (MADRS, BPRS, YRMS) and blood lipid profiling in a clinical setting. For analysis of psychopharmacotherapy, medication was split into activating (AM) and inhibiting (IM) medication and dosages were normalized by the respective WHO defined daily dose. RESULTS: While we observed a significant decrease of the MADRS score and increase of the relative total F(max) (rTF(max)) in the first two weeks (t(1)-t(2)) but not later (both p < .001), we did not reveal a significant bivariate correlation between disease severity (MADRS) and muscle strength (rTF(max)) at any of the timepoints. Individuals with longer disease history displayed reduced rTF(max) (p = .048). IM was significantly associated with decreased rTF(max) (p = .032). Regression models provide a more substantial effect of gender, age, and IM on muscle strength than the depressive episode itself (p < .001). CONCLUSIONS: The results of the study indicate that disease severity and muscle strength are not associated in young to middle-aged inpatients with affective disorders using a strength circuit as observational measurement. Future research will be needed to differentiate the effect of medication, gender, and age on muscle strength and to develop interventions for prevention of muscle weakness, especially in younger patients with chronic affective illnesses. CI - (c) 2024. The Author(s). FAU - Ramming, Hannah AU - Ramming H AD - Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Wurzburg, Margarete-Hoppel-Platz 1, 97080, Wurzburg, Germany. FAU - Theuerkauf, Linda AU - Theuerkauf L AUID- ORCID: 0000-0003-3578-846X AD - Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Wurzburg, Margarete-Hoppel-Platz 1, 97080, Wurzburg, Germany. FAU - Hoos, Olaf AU - Hoos O AUID- ORCID: 0000-0002-1485-0351 AD - Center for Sports and Physical Education, University of Wurzburg, Am Hubland, 97074, Wurzburg, Germany. FAU - Lichter, Katharina AU - Lichter K AUID- ORCID: 0000-0003-3057-6150 AD - Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Wurzburg, Margarete-Hoppel-Platz 1, 97080, Wurzburg, Germany. AD - Institute of Science and Technology Austria, Am Campus 1, Klosterneuburg, 3400, Austria. FAU - Kittel-Schneider, Sarah AU - Kittel-Schneider S AD - Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Wurzburg, Margarete-Hoppel-Platz 1, 97080, Wurzburg, Germany. skittelschneider@ucc.ie. AD - Department of Psychiatry and Neurobehavioural Science, Acute Mental Health Unit, University College Cork, Cork University Hospital, Wilton, Cork, T12DC4A, Ireland. skittelschneider@ucc.ie. LA - eng PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20240529 PL - England TA - BMC Psychiatry JT - BMC psychiatry JID - 100968559 SB - IM MH - Humans MH - *Muscle Strength/drug effects/physiology MH - Male MH - Pilot Projects MH - Adult MH - Female MH - Prospective Studies MH - Middle Aged MH - Young Adult MH - Adolescent MH - Inpatients MH - Bipolar Disorder/drug therapy/physiopathology MH - Major Depressive Disorder/drug therapy/physiopathology MH - Psychotic Disorders/drug therapy/physiopathology MH - Severity of Illness Index PMC - PMC11137909 OTO - NOTNLM OT - Affective disorder OT - Bipolar disorder OT - Depression OT - Muscle strength OT - Physical activity OT - Psychopharmacotherapy OT - Young COIS- S.K.-S. has received author's and speaker's honoraria from Medice Arzneimittel Putter GmbH & Co KG, Janssen and Takeda. All other authors declare no conflicts of interest regarding this work. EDAT- 2024/05/30 05:44 MHDA- 2024/05/30 06:35 PMCR- 2024/05/29 CRDT- 2024/05/29 23:46 PHST- 2024/01/17 00:00 [received] PHST- 2024/05/14 00:00 [accepted] PHST- 2024/05/30 06:35 [medline] PHST- 2024/05/30 05:44 [pubmed] PHST- 2024/05/29 23:46 [entrez] PHST- 2024/05/29 00:00 [pmc-release] AID - 10.1186/s12888-024-05849-2 [pii] AID - 5849 [pii] AID - 10.1186/s12888-024-05849-2 [doi] PST - epublish SO - BMC Psychiatry. 2024 May 29;24(1):401. doi: 10.1186/s12888-024-05849-2. PMID- 38810411 OWN - NLM STAT- MEDLINE DCOM- 20240606 LR - 20240606 IS - 1532-2653 (Electronic) IS - 0967-5868 (Linking) VI - 125 DP - 2024 Jul TI - Combining conventional and smartphone technologies to evaluate the psychomotor status in chronic malnutrition: A cross-sectional pilot study in sub-Saharan Africa. PG - 141-145 LID - S0967-5868(24)00219-4 [pii] LID - 10.1016/j.jocn.2024.05.031 [doi] AB - Malnutrition remains a pressing health concern in developing nations, contributing to growth delay (stunting) and psychomotor impairments among the youth. Tanzania has the highest prevalence of stunting, yet the psychomotor status of its population has not been previously studied. To address this gap, we gathered anthropometric, nutritional, and psychomotor data from 211 children with the aim of assessing the reliability of digital tools as indicators of psychomotor performance in relation to the nutritional status. Collected anthropometric measures included middle-upper arm circumference (MUAC), triceps skinfold thickness (TST), and handgrip strength, while psychomotor variables were assessed using digital finger tapping test (DFTT), eye-tracking test (ETT), and nine-hole peg test (9HPT). Statistical analysis revealed significant associations between age and both MUAC and handgrip strength (R = 0.5, p < 0.001). Moreover, DFTT and 9HPT demonstrated a correlation with each other (p = 0.026) and with MUAC, handgrip strength, and age (p < 0.001). Notably, lower stature was independently linked to slower horizontal eye movements (p < 0.001). Findings underscores the crucial link between nutrition and psychomotor skills in Tanzanian children. Digital tests like DFTT, ETT, and the 9HPT show promise for assessing psychomotor performance. Addressing malnutrition requires comprehensive interventions. Future research should explore long-term effects of interventions in resource-limited settings. CI - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Marano, Massimo AU - Marano M AD - Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy; Department of Medicine and Surgery, Unit of Neurology, Neurophysiology, Neurobiology, and Psychiatry, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy. Electronic address: m.marano@policlinicocampus.it. FAU - Todisco, Antonio AU - Todisco A AD - Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy; Department of Medicine and Surgery, Unit of Neurology, Neurophysiology, Neurobiology, and Psychiatry, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy. FAU - Fattori, Silvia AU - Fattori S AD - Faculty of Medicine and Surgery, University of Trieste, Trieste, Italy. FAU - Valente, Maria Stella AU - Valente MS AD - Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy. FAU - Di Loreto, Maria Vittoria AU - Di Loreto MV AD - Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy. FAU - Fantozzi, Italo Cesidio AU - Fantozzi IC AD - Department of Enterprise Engineering, University of Rome "Tor Vergata", Via del Politecnico, 1, 00133 Rome, Italy. FAU - Albergo, Giuliano AU - Albergo G AD - Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy; Department of Medicine and Surgery, Unit of Neurology, Neurophysiology, Neurobiology, and Psychiatry, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy. FAU - Nusca, Annunziata AU - Nusca A AD - Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy; Department of Medicine and Surgery, Unit of Cardiology, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy. FAU - Napoli, Nicola AU - Napoli N AD - Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy; Department of Medicine and Surgery, Research Unit of Endocrinology and Diabetes, Universita Campus Bio-Medico di Roma, Rome, Italy. FAU - Di Lazzaro, Vincenzo AU - Di Lazzaro V AD - Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy; Department of Medicine and Surgery, Unit of Neurology, Neurophysiology, Neurobiology, and Psychiatry, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy. LA - eng PT - Journal Article DEP - 20240528 PL - Scotland TA - J Clin Neurosci JT - Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia JID - 9433352 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Female MH - Pilot Projects MH - Child MH - *Psychomotor Performance/physiology MH - Child, Preschool MH - Tanzania/epidemiology MH - *Smartphone MH - *Malnutrition/diagnosis/epidemiology MH - Hand Strength/physiology MH - Nutritional Status/physiology MH - Anthropometry/methods MH - Adolescent OTO - NOTNLM OT - Eye tracking OT - Finger tapping OT - Malnutrition OT - Neurodevelopment OT - Stunting OT - Tanzania COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/05/30 05:44 MHDA- 2024/06/07 00:43 CRDT- 2024/05/29 18:05 PHST- 2024/03/03 00:00 [received] PHST- 2024/05/01 00:00 [revised] PHST- 2024/05/23 00:00 [accepted] PHST- 2024/06/07 00:43 [medline] PHST- 2024/05/30 05:44 [pubmed] PHST- 2024/05/29 18:05 [entrez] AID - S0967-5868(24)00219-4 [pii] AID - 10.1016/j.jocn.2024.05.031 [doi] PST - ppublish SO - J Clin Neurosci. 2024 Jul;125:141-145. doi: 10.1016/j.jocn.2024.05.031. Epub 2024 May 28. PMID- 38809550 OWN - NLM STAT- MEDLINE DCOM- 20240529 LR - 20250211 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 7 IP - 5 DP - 2024 May 1 TI - Algorithmic Content Recommendations on a Video-Sharing Platform Used by Children. PG - e2413855 LID - 10.1001/jamanetworkopen.2024.13855 [doi] LID - e2413855 AB - IMPORTANCE: Free video-sharing platforms (VSPs) make up a high proportion of children's daily screen use. Many VSPs make algorithmic recommendations, appearing as thumbnail images from the video, which content creators use to advertise their video content. OBJECTIVE: To explore how VSP thumbnails use attention-capture designs to encourage engagement with content and to test whether VSP algorithmic recommendations offer more problematic thumbnail features over time. DESIGN, SETTING, AND PARTICIPANTS: In this cross-sectional study conducted in January 2022, researchers mimicked the search behavior of children on a popular VSP by randomly clicking on recommended videos in order to test whether thumbnail designs changed over 20 sequential video engagements. A digital, footprint-free data collection setting was created by using a new computer and wireless internet router. Data were collected from YouTube via an internet browser not logged into a user account. Data analysis occurred from April to December 2022. EXPOSURES: Manual searches using 12 top-searched terms popular with school-aged children were conducted. Researchers captured the video thumbnails recommended at the end of each video and randomly clicked subsequent videos for 20 sequential engagements. MAIN OUTCOMES AND MEASURES: Thumbnail content codes were developed through iterative review of screenshots by a multidisciplinary research team and applied by trained coders (reliability, kappa >.70). The prevalence of problematic thumbnail content and change in prevalence over 20 engagements was calculated using the Cochran-Armitage trend test. RESULTS: A total of 2880 video thumbnails were analyzed and 6 features were coded, including visual loudness; drama and intrigue; lavish excess and wish fulfillment; creepy, bizarre, and disturbing; violence, peril, and pranks; and gender stereotypes. A high proportion contained problematic features including the creepy, bizarre, and disturbing feature (1283 thumbnails [44.6%]), violence, peril, and pranks feature (1170 thumbnails [40.6%]), and gender stereotypes feature (525 thumbnails [18.2%]). Other features included attention-capture designs such as the visual loudness feature (2278 thumbnails [79.1%]), drama and intrigue feature (2636 thumbnails [91.5%]) and lavish excess and wish fulfillment feature (1286 thumbnails [44.7%]). Contrary to the hypotheses, problematic feature prevalence did not increase over time, but the gender stereotypes feature increased with more engagement in the recommendations feed (P for trend < .001). CONCLUSIONS AND RELEVANCE: In this study of video recommendations for search terms popular with children, thumbnails contained problematic and attention-capturing designs including violent, stereotyped, and frightening themes. Research is needed to understand how children respond to thumbnail designs and whether such designs influence the quality of content children consume. FAU - Radesky, Jenny AU - Radesky J AD - Department of Pediatrics, University of Michigan Medical School, Ann Arbor. FAU - Bridgewater, Enrica AU - Bridgewater E AD - Department of Communication & Media, University of Michigan, Ann Arbor. AD - Department of Psychology, University of Michigan, Ann Arbor. FAU - Black, Shira AU - Black S AD - Department of Communication & Media, University of Michigan, Ann Arbor. FAU - O'Neil, August AU - O'Neil A AD - Department of Communication & Media, University of Michigan, Ann Arbor. FAU - Sun, Yilin AU - Sun Y AD - Department of Communication & Media, University of Michigan, Ann Arbor. FAU - Schaller, Alexandria AU - Schaller A AD - Department of Pediatrics, University of Michigan Medical School, Ann Arbor. FAU - Weeks, Heidi M AU - Weeks HM AD - Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor. FAU - Campbell, Scott W AU - Campbell SW AD - Department of Communication & Media, University of Michigan, Ann Arbor. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240501 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Child MH - Male MH - Female MH - *Algorithms MH - *Video Recording MH - Social Media/statistics & numerical data MH - Screen Time MH - Adolescent PMC - PMC11137630 COIS- Conflict of Interest Disclosures: Dr Radesky reported receiving grants from Common Sense Media outside the submitted work. No other disclosures were reported. EDAT- 2024/05/29 12:44 MHDA- 2024/05/29 12:45 PMCR- 2024/05/29 CRDT- 2024/05/29 11:34 PHST- 2024/05/29 12:45 [medline] PHST- 2024/05/29 12:44 [pubmed] PHST- 2024/05/29 11:34 [entrez] PHST- 2024/05/29 00:00 [pmc-release] AID - 2819134 [pii] AID - zoi240474 [pii] AID - 10.1001/jamanetworkopen.2024.13855 [doi] PST - epublish SO - JAMA Netw Open. 2024 May 1;7(5):e2413855. doi: 10.1001/jamanetworkopen.2024.13855. PMID- 38807356 OWN - NLM STAT- MEDLINE DCOM- 20240823 LR - 20260407 IS - 1564-8265 (Electronic) IS - 0379-5721 (Linking) VI - 45 IP - 2_suppl DP - 2024 Sep TI - Exploring the FAO Minimum Dietary Diversity Indicator as a Suitable Proxy of Micronutrient Adequacy in Men and Women Across Reproductive and Non-reproductive Ages in 8 Latin American Countries. PG - S55-S65 LID - 10.1177/03795721241242920 [doi] AB - BACKGROUND: Women's Dietary Diversity Score (WDDS) is an indicator of dietary diversity, a key component of diet quality in women of reproductive age (WRA). Limited information is available regarding its applicability in other population groups. OBJECTIVE: To examine the ability of the Minimum Dietary Diversity for Women (MDD-W) of 5-food groups cutoff to predict micronutrient adequacy in men and women 15 to 65 years old from 8 Latin American countries. METHODS: We used a 24-hour recall from 9216 participants in the Latin American Study on Nutrition and Health (ELANS) to determine Dietary Diversity Score (DDS) based on the consumption of 10 food groups. The Mean Probability of Adequacy (MPA) was associated with DDS for the overall sample, for men, WRA, and women of nonreproductive age (WNRA). Sensitivity and specificity analyses were performed to determine if the 5-food groups cutoff point for MDD can be used to correctly identify men, WRA, and WNRA with adequate micronutrient adequacy (MPA >/= 0.70). RESULTS: We found a mean DDS of 4.78 +/- 1.33 and an MPA of 0.64 +/- 0.16, with 59% of participants showing a diverse diet (DDS >/= 5). The 5-food groups-cutoff point showed a better balance between sensitivity and specificity predicting an MPA >/=0.70 in men, WRA, and WNRA. MPA was significantly associated with DDS in WRA and for men and WNRA, as well. CONCLUSION: The 5-food group MDD, originally intended to be used in WRA, performed equally well in predicting MPA >/=0.70 in men, WRA, and WNRA, and can be used as a proxy of micronutrient adequacy in Latin American population. FAU - Gomez, Georgina AU - Gomez G AUID- ORCID: 0000-0003-3514-2984 AD - Universidad de Costa Rica, San Jose, Costa Rica. FAU - Monge-Rojas, Rafael AU - Monge-Rojas R AUID- ORCID: 0000-0001-7660-2508 AD - Instituto Costarricense de Investigacion en Nutricion y Salud (INCIENSA), Tres Rios, Cartago, Costa Rica. FAU - Vargas-Quesada, Rulaman AU - Vargas-Quesada R AD - Instituto Costarricense de Investigacion en Nutricion y Salud (INCIENSA), Tres Rios, Cartago, Costa Rica. FAU - Previdelli, Agatha Nogueira AU - Previdelli AN AD - Universidad Autonoma de Chile, Providencia, Chile. FAU - Quesada, Dayana AU - Quesada D AD - Universidad de Costa Rica, San Jose, Costa Rica. FAU - Kovalskys, Irina AU - Kovalskys I AUID- ORCID: 0000-0001-8481-5415 AD - Pontificia Universidad Catolica Argentina, Buenos Aires, Argentina. FAU - Herrera-Cuenca, Marianella AU - Herrera-Cuenca M AD - Universidad Central de Venezuela, Caracas, Venezuela. AD - Framingham State University, MA, USA. FAU - Cortes, Lilia Yadira AU - Cortes LY AD - Pontificia Universidad Javeriana, Bogota, Colombia. FAU - Garcia, Martha Cecilia Yepez AU - Garcia MCY AD - Universidad San Francisco de Quito, Quito, Ecuador. FAU - Liria-Dominguez, Reyna AU - Liria-Dominguez R AD - Instituto de Investigacion Nutricional, Lima, Peru. FAU - Rigotti, Attilio AU - Rigotti A AD - Pontificia Universidad Catolica, Santiago, Chile. FAU - Fisberg, Regina Mara AU - Fisberg RM AD - University of Sao Paulo, Sao Paulo, Brazil. FAU - Ferrari, Gerson AU - Ferrari G AD - Universidad Autonoma de Chile, Providencia, Chile. FAU - Fisberg, Mauro AU - Fisberg M AUID- ORCID: 0000-0003-2992-3215 AD - Instituto Pensi, Sao Paulo, Brazil. FAU - Brenes, Juan C AU - Brenes JC AD - Universidad de Costa Rica, San Jose, Costa Rica. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240528 PL - United States TA - Food Nutr Bull JT - Food and nutrition bulletin JID - 7906418 RN - 0 (Micronutrients) SB - IM MH - Humans MH - Female MH - Male MH - *Micronutrients/administration & dosage MH - Adult MH - Latin America MH - Middle Aged MH - Adolescent MH - Young Adult MH - Aged MH - *Diet/statistics & numerical data/methods MH - Nutritional Status MH - United Nations OAB - Plain language titleAssessment of the FAO Minimum Dietary Diversity Index to Estimate Micronutrients Intake in Urban Cities of 8 Latin America CountriesPlain language summaryThe Women's Dietary Diversity Score (WDDS) proposed by the Food and Agriculture Organization is an indicator that measures the variety of foods consumed by women of reproductive age (WRA), and it has been reported in several studies that the more diverse the diet, the greater the probability of meeting micronutrients requirements. This indicator has not been validated in other population, but few studies have been conducted in the Latin American region. So, we aimed to investigate whether the Minimum Dietary Diversity for Women (MDD-W) established for WRA could also predict sufficient micronutrient intake in men and women aged 15 to 65 years in the Latin American population. To accomplish this objective, we used data from the Latin American Study of Nutrition and Health (Estudio Latino Americano de Nutricion y Salud-ELANS) that collected dietary data from 24-h recalls from 9216 participants and analyzed the association between DDS and the Mean Probability of Adequacy (MPA). Additionally, we determined if the MDD cutoff point could correctly identify individuals with appropriate vitamin and mineral intake. We found that the overall mean DDS was 4.78 +/- 1.33, the MPA was 0.64 +/- 0.16, and approximately 59% of participants had a diverse diet. The MDD of 5-food groups cutoff point was demonstrated to be useful in predicting sufficient micronutrient intake for men, WRA, and women over 50 years. Respondents with a DDS >/=5 had higher micronutrient adequacy. These findings suggest that DDS can serve as a proxy for assessing micronutrient adequacy in urban populations beyond WRA. The effect of promoting diverse diets on micronutrient adequacy as part of intervention programs can be captured by the DDS in urban Latin American populations. OABL- eng OTO - NOTNLM OT - Latin America OT - cross-sectional study OT - diet OT - dietary diversity OT - micronutrients OT - nutrition assessment OT - survey COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2024/05/29 06:42 MHDA- 2024/08/23 12:46 CRDT- 2024/05/29 01:32 PHST- 2024/08/23 12:46 [medline] PHST- 2024/05/29 06:42 [pubmed] PHST- 2024/05/29 01:32 [entrez] AID - 10.1177/03795721241242920 [doi] PST - ppublish SO - Food Nutr Bull. 2024 Sep;45(2_suppl):S55-S65. doi: 10.1177/03795721241242920. Epub 2024 May 28. PMID- 38805982 OWN - NLM STAT- MEDLINE DCOM- 20240529 LR - 20250806 IS - 1980-5322 (Electronic) IS - 1807-5932 (Print) IS - 1807-5932 (Linking) VI - 79 DP - 2024 TI - Clinical research of fibroscan ‒ TE-CAP at noninvasive diagnosis of hepatic steatosis in children. PG - 100387 LID - S1807-5932(24)00064-4 [pii] LID - 10.1016/j.clinsp.2024.100387 [doi] LID - 100387 AB - BACKGROUND & AIMS: The authors assess the diagnostic accuracy of the Transient Elastography-Controlled Attenuation Parameter (TE-CAP) in children of Southern China. METHODS: 105 obese or overweight children and adolescents were enrolled in the diagnostic test of TE-CAP assessment of hepatic steatosis using MRI-PDFF. Hepatic steatosis grades S0-S3 were classified. Statistical correlation, agreement and consistency between methods were evaluated. The diagnostic efficiency of TE-CAP was evaluated. The authors used the cutoff value of TE-CAP to detect hepatic steatosis in another 356 children. RESULTS: The Area Under Curve (AUC) of TE-CAP for grade >/= S1, >/= S2, and >/= S3 steatosis were 0.975, 0.984, and 0.997, respectively. For detecting >/= S1 steatosis, TE-CAP had a sensitivity of 96 % and a specificity of 97 %. For detecting >/= S2 steatosis, TE-CAP had a sensitivity of 97 % and a specificity of 93 %. For detecting >/= S3 steatosis, TE-CAP had a sensitivity of 1 and a specificity of 94 %. TE-CAP and MRI-PDFF had a linear correlation (r = 0. 0.87, p < 0.001). The hepatic steatosis was identified in 40.2 % (143/356) of children in which the obesity and overweight were 69.8 % (113/162) and 40.0 % (18/45). CONCLUSION: TE-CAP showed excellent diagnostic accuracy in pediatric hepatic steatosis. CI - Copyright (c) 2024 HCFMUSP. Published by Elsevier Espana, S.L.U. All rights reserved. FAU - Jia, Shuangzhen AU - Jia S AD - Department of Gastroenterology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing City, China. FAU - Zhou, Jianli AU - Zhou J AD - Department of Gastroenterology, Shenzhen Children's Hospital, Shenzhen City, China. FAU - Zhang, Qiao AU - Zhang Q AD - Department of Gastroenterology, Shenzhen Children's Hospital, Shenzhen City, China. FAU - Zhou, Shaoming AU - Zhou S AD - Department of Gastroenterology, Shenzhen Children's Hospital, Shenzhen City, China. FAU - Wang, Zhaoxia AU - Wang Z AD - Department of Gastroenterology, Shenzhen Children's Hospital, Shenzhen City, China. FAU - Ye, Xiaolin AU - Ye X AD - Department of Gastroenterology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing City, China. FAU - Wu, Jie AU - Wu J AD - Department of Gastroenterology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing City, China. Electronic address: wujie@bch.com.cn. LA - eng PT - Evaluation Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240527 PL - United States TA - Clinics (Sao Paulo) JT - Clinics (Sao Paulo, Brazil) JID - 101244734 SB - IM MH - Humans MH - Child MH - *Elasticity Imaging Techniques/methods MH - Male MH - Female MH - Adolescent MH - *Fatty Liver/diagnostic imaging MH - *Magnetic Resonance Imaging/methods MH - *Sensitivity and Specificity MH - Reproducibility of Results MH - China MH - Area Under Curve MH - Severity of Illness Index MH - Overweight/diagnostic imaging MH - Reference Values PMC - PMC11152890 OTO - NOTNLM OT - Child OT - Diagnosis OT - Fat liver OT - Non-alcoholic Fatty Liver Disease COIS- Conflicts of interest The authors declare no conflicts of interest. EDAT- 2024/05/29 00:49 MHDA- 2024/05/29 12:46 PMCR- 2024/05/27 CRDT- 2024/05/28 18:19 PHST- 2024/04/12 00:00 [received] PHST- 2024/04/29 00:00 [accepted] PHST- 2024/05/29 12:46 [medline] PHST- 2024/05/29 00:49 [pubmed] PHST- 2024/05/28 18:19 [entrez] PHST- 2024/05/27 00:00 [pmc-release] AID - S1807-5932(24)00064-4 [pii] AID - 100387 [pii] AID - 10.1016/j.clinsp.2024.100387 [doi] PST - epublish SO - Clinics (Sao Paulo). 2024 May 27;79:100387. doi: 10.1016/j.clinsp.2024.100387. eCollection 2024. PMID- 38802955 OWN - NLM STAT- MEDLINE DCOM- 20240528 LR - 20250530 IS - 1756-994X (Electronic) IS - 1756-994X (Linking) VI - 16 IP - 1 DP - 2024 May 28 TI - Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause. PG - 69 LID - 10.1186/s13073-024-01322-7 [doi] LID - 69 AB - BACKGROUND: The role of metabolism in the variation of age at menarche (AAM) and age at natural menopause (ANM) in the female population is not entirely known. We aimed to investigate the causal role of circulating metabolites in AAM and ANM using Mendelian randomization (MR). METHODS: We combined MR with genetic colocalization to investigate potential causal associations between 658 metabolites and AAM and between 684 metabolites and ANM. We extracted genetic instruments for our exposures from four genome-wide association studies (GWAS) on circulating metabolites and queried the effects of these variants on the outcomes in two large GWAS from the ReproGen consortium. Additionally, we assessed the mediating role of the body mass index (BMI) in these associations, identified metabolic pathways implicated in AAM and ANM, and sought validation for selected metabolites in the Avon Longitudinal Study of Parents and Children (ALSPAC). RESULTS: Our analysis identified 10 candidate metabolites for AAM, but none of them colocalized with AAM. For ANM, 76 metabolites were prioritized (FDR-adjusted MR P-value 10% of their energy intake in each category were also calculated. RESULTS: Totally 970 subjects (482 girls) with a mean age of 5.00 years (SD = 0.85) were studied. Children who watched TV during meals >/=4 times/week consumed a mean of 4.67% more energy from UPF than those who watch TV <3 times/month. The adjusted proportions of children who had a free sugar intake >10% of their energy intake in the categories of <3 times/month, 1-3 times/week and >/=4 times/week exposure to TV during meals were 44.9%, 45.9% and 58.7%, respectively. CONCLUSION: TV watching during meals is associated with higher consumption of UPFs and a higher risk of exceeding 10% of TEI in free sugar intake in childhood. CI - (c) 2024 The Author(s). Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation. FAU - Martin-Calvo, Nerea AU - Martin-Calvo N AUID- ORCID: 0000-0001-7549-1455 AD - Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, Medical Research Institute of Navarra (IdiSNA), Pamplona, Spain. AD - CIBER Pathophysiology of Obesity and Nutrition (CIBERobn), Carlos III Health Institute, Madrid, Spain. FAU - Usechi, Ane AU - Usechi A AD - Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, Medical Research Institute of Navarra (IdiSNA), Pamplona, Spain. FAU - Fabios, Elise AU - Fabios E AD - Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, Medical Research Institute of Navarra (IdiSNA), Pamplona, Spain. FAU - Gomez, Santiago Felipe AU - Gomez SF AD - Gasol Foundation Europe, Sant Boi de Llobregat, Barcelona, Spain. AD - Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar Research Institute, Barcelona, Spain. AD - Nursing and Physiotherapy Department, University of Lleida, Lleida, Spain. AD - CIBER Epidemiology and Public Health (CIBERESP), Carlos III Health Institute, Madrid, Spain. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AUID- ORCID: 0000-0002-7412-7624 AD - One Health Research Group, Universidad de Las Americas, Quito, Ecuador. LA - eng PT - Journal Article DEP - 20240524 PL - England TA - Pediatr Obes JT - Pediatric obesity JID - 101572033 RN - 0 (Dietary Sugars) SB - IM MH - Humans MH - *Television/statistics & numerical data MH - Female MH - Male MH - Child, Preschool MH - *Meals MH - *Fast Foods/statistics & numerical data/adverse effects MH - *Energy Intake MH - *Feeding Behavior MH - Child MH - Dietary Sugars MH - Sedentary Behavior MH - Food, Processed OTO - NOTNLM OT - NOVA classification OT - childhood OT - screen OT - television OT - ultra-processed foods EDAT- 2024/05/24 12:45 MHDA- 2024/07/11 06:42 CRDT- 2024/05/24 07:33 PHST- 2024/04/22 00:00 [revised] PHST- 2024/01/11 00:00 [received] PHST- 2024/05/07 00:00 [accepted] PHST- 2024/07/11 06:42 [medline] PHST- 2024/05/24 12:45 [pubmed] PHST- 2024/05/24 07:33 [entrez] AID - 10.1111/ijpo.13130 [doi] PST - ppublish SO - Pediatr Obes. 2024 Aug;19(8):e13130. doi: 10.1111/ijpo.13130. Epub 2024 May 24. PMID- 38783784 OWN - NLM STAT- MEDLINE DCOM- 20240808 LR - 20260420 IS - 1467-789X (Electronic) IS - 1467-7881 (Linking) VI - 25 IP - 9 DP - 2024 Sep TI - Validity of dietary assessment methods compared with doubly labeled water in children: A systematic review and meta-analysis. PG - e13768 LID - 10.1111/obr.13768 [doi] AB - OBJECTIVES: We aimed to validate dietary assessment methods against the gold standard, doubly labeled water (DLW), for estimating total energy intake (TEI). METHODS: PubMed, Scopus, Web of Science, and Google Scholar databases were searched until May 2023. Inclusion criteria encompassed studies involving participants aged 1-18 years, employing dietary assessment methods like food records, dietary histories, food frequency questionnaire (FFQ), or 24-h recalls estimating TEI alongside DLW to measure total energy expenditure (TEE). Data were pooled using random-effects meta-analysis models. RESULTS: Thirty-three studies were identified, with sample sizes ranging from 9 to 118 participants. Meta-analysis of 22 studies identified underestimation of TEI (mean difference [MD] = -262.9 kcal/day [95% CI: -380.0, -145.8]; I(2) = 93.55%) for food records compared with TEE estimated by DLW. Other dietary assessment methods, including food recalls (n = 9) (MD = 54.2 kcal/day [95% CI: -19.8, 128.1]; I(2) = 49.62%), FFQ (n = 7) (MD = 44.5 kcal/day [95% CI: -317.8, 406.8]; I(2) = 94.94%), and diet history (n = 3) (MD = -130.8 kcal/day [95% CI: -455.8, 194.1]; I(2) = 77.48%), showed no significant differences in TEI compared with DLW-estimated TEE. All studies were of high quality. CONCLUSION: Food records may underestimate TEI, yet additional research is needed to identify the most accurate methods for assessing children's dietary intake. CI - (c) 2024 World Obesity Federation. FAU - Mehranfar, Sanaz AU - Mehranfar S AUID- ORCID: 0000-0001-8199-0058 AD - Department of Community Nutrition, School of Nutritional Science and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. FAU - Jalilpiran, Yahya AU - Jalilpiran Y AD - Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran. AD - Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. FAU - Jafari, Alireza AU - Jafari A AUID- ORCID: 0000-0003-2475-1928 AD - Department of Community Nutrition, School of Nutritional Science and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. AD - Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. FAU - Jayedi, Ahmad AU - Jayedi A AUID- ORCID: 0000-0003-4231-3147 AD - Department of Community Nutrition, School of Nutritional Science and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. AD - Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran. FAU - Shab-Bidar, Sakineh AU - Shab-Bidar S AUID- ORCID: 0000-0002-0167-7174 AD - Department of Community Nutrition, School of Nutritional Science and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. FAU - Speakman, John R AU - Speakman JR AUID- ORCID: 0000-0002-2457-1823 AD - Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK. FAU - Djafarian, Kurosh AU - Djafarian K AD - Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. AD - Neuroscience Institute, Sports Medicine Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran. LA - eng PT - Comparative Study PT - Journal Article PT - Meta-Analysis PT - Systematic Review PT - Validation Study DEP - 20240524 PL - England TA - Obes Rev JT - Obesity reviews : an official journal of the International Association for the Study of Obesity JID - 100897395 RN - 0 (Oxygen Isotopes) RN - 059QF0KO0R (Water) SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Humans MH - Infant MH - Diet MH - Diet Records MH - Diet Surveys/standards MH - *Energy Intake MH - Energy Metabolism/physiology MH - *Nutrition Assessment MH - Oxygen Isotopes/analysis MH - Reproducibility of Results MH - Water OTO - NOTNLM OT - Diet history OT - doubly labeled water OT - energy intake OT - food frequency questionnaires OT - food recalls OT - food record OT - total energy expenditure EDAT- 2024/05/24 06:42 MHDA- 2024/08/09 00:42 CRDT- 2024/05/24 03:22 PHST- 2024/04/20 00:00 [revised] PHST- 2023/05/10 00:00 [received] PHST- 2024/04/20 00:00 [accepted] PHST- 2024/08/09 00:42 [medline] PHST- 2024/05/24 06:42 [pubmed] PHST- 2024/05/24 03:22 [entrez] AID - 10.1111/obr.13768 [doi] PST - ppublish SO - Obes Rev. 2024 Sep;25(9):e13768. doi: 10.1111/obr.13768. Epub 2024 May 24. PMID- 38783240 OWN - NLM STAT- MEDLINE DCOM- 20240524 LR - 20240717 IS - 1471-2407 (Electronic) IS - 1471-2407 (Linking) VI - 24 IP - 1 DP - 2024 May 23 TI - Construction and validation of a novel tumor morphology immune inflammatory nutritional score (TIIN score) for intrahepatic cholangiocarcinoma: a multicenter study. PG - 630 LID - 10.1186/s12885-024-12375-7 [doi] LID - 630 AB - BACKGROUND: Tumor morphology, immune function, inflammatory levels, and nutritional status play critical roles in the progression of intrahepatic cholangiocarcinoma (ICC). This multicenter study aimed to investigate the association between markers related to tumor morphology, immune function, inflammatory levels, and nutritional status with the prognosis of ICC patients. Additionally, a novel tumor morphology immune inflammatory nutritional score (TIIN score), integrating these factors was constructed. METHODS: A retrospective analysis was performed on 418 patients who underwent radical surgical resection and had postoperative pathological confirmation of ICC between January 2016 and January 2020 at three medical centers. The cohort was divided into a training set (n = 272) and a validation set (n = 146). The prognostic significance of 16 relevant markers was assessed, and the TIIN score was derived using LASSO regression. Subsequently, the TIIN-nomogram models for OS and RFS were developed based on the TIIN score and the results of multivariate analysis. The predictive performance of the TIIN-nomogram models was evaluated using ROC survival curves, calibration curves, and clinical decision curve analysis (DCA). RESULTS: The TIIN score, derived from albumin-to-alkaline phosphatase ratio (AAPR), albumin-globulin ratio (AGR), monocyte-to-lymphocyte ratio (MLR), and tumor burden score (TBS), effectively categorized patients into high-risk and low-risk groups using the optimal cutoff value. Compared to individual metrics, the TIIN score demonstrated superior predictive value for both OS and RFS. Furthermore, the TIIN score exhibited strong associations with clinical indicators including obstructive jaundice, CEA, CA19-9, Child-pugh grade, perineural invasion, and 8th edition AJCC N stage. Univariate and multivariate analysis confirmed the TIIN score as an independent risk factor for postoperative OS and RFS in ICC patients (p < 0.05). Notably, the TIIN-nomogram models for OS and RFS, constructed based on the multivariate analysis and incorporating the TIIN score, demonstrated excellent predictive ability for postoperative survival in ICC patients. CONCLUSION: The development and validation of the TIIN score, a comprehensive composite index incorporating tumor morphology, immune function, inflammatory level, and nutritional status, significantly contribute to the prognostic assessment of ICC patients. Furthermore, the successful application of the TIIN-nomogram prediction model underscores its potential as a valuable tool in guiding individualized treatment strategies for ICC patients. These findings emphasize the importance of personalized approaches in improving the clinical management and outcomes of ICC. CI - (c) 2024. The Author(s). FAU - Zhang, Haofeng AU - Zhang H AD - Department of Hepatobiliary and Pancreatic Surgery, People's Hospital of Zhengzhou University, Zhengzhou, 450000, China. AD - Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou, 450000, China. FAU - Huang, Guan AU - Huang G AD - Department of Hepatobiliary and Pancreatic Surgery, People's Hospital of Zhengzhou University, Zhengzhou, 450000, China. AD - Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou, 450000, China. FAU - Li, Qingshan AU - Li Q AD - Department of Hepatobiliary and Pancreatic Surgery, People's Hospital of Zhengzhou University, Zhengzhou, 450000, China. AD - Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou, 450000, China. FAU - Wang, Yanbo AU - Wang Y AD - Department of Hepatobiliary and Pancreatic Surgery, People's Hospital of Zhengzhou University, Zhengzhou, 450000, China. AD - Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou, 450000, China. FAU - Yang, Zhenwei AU - Yang Z AD - Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou, 450000, China. FAU - Chen, Pengyu AU - Chen P AD - Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou, 450000, China. FAU - Yuan, Hao AU - Yuan H AD - Department of Hepatobiliary and Pancreatic Surgery, People's Hospital of Zhengzhou University, Zhengzhou, 450000, China. AD - Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou, 450000, China. FAU - Chen, Kunlun AU - Chen K AD - Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China. FAU - Meng, Bo AU - Meng B AD - Department of Hepatobiliary and Pancreatic Surgery, Cancer Hospital of Zhengzhou University, Zhengzhou, 450000, China. FAU - Yu, Haibo AU - Yu H AD - Department of Hepatobiliary and Pancreatic Surgery, People's Hospital of Zhengzhou University, Zhengzhou, 450000, China. yhb2101661@163.com. AD - Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou, 450000, China. yhb2101661@163.com. LA - eng PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20240523 PL - England TA - BMC Cancer JT - BMC cancer JID - 100967800 RN - 0 (Biomarkers, Tumor) RN - EC 3.1.3.1 (Alkaline Phosphatase) RN - 0 (Serum Albumin) SB - IM MH - Humans MH - *Cholangiocarcinoma/surgery/pathology MH - Male MH - Female MH - Retrospective Studies MH - *Bile Duct Neoplasms/surgery/pathology MH - Middle Aged MH - *Nutritional Status MH - Prognosis MH - Aged MH - Nomograms MH - Inflammation MH - Biomarkers, Tumor MH - Alkaline Phosphatase/blood MH - Tumor Burden MH - Nutrition Assessment MH - Serum Albumin/analysis/metabolism MH - ROC Curve MH - Monocytes/pathology PMC - PMC11112867 OTO - NOTNLM OT - Immunity OT - Inflammation OT - Intrahepatic cholangiocarcinoma OT - Nomogram OT - Nutrition OT - Prognosis OT - Tumor morphology COIS- The authors declare no competing interests. EDAT- 2024/05/24 00:42 MHDA- 2024/05/24 06:43 PMCR- 2024/05/23 CRDT- 2024/05/23 23:50 PHST- 2024/01/02 00:00 [received] PHST- 2024/05/13 00:00 [accepted] PHST- 2024/05/24 06:43 [medline] PHST- 2024/05/24 00:42 [pubmed] PHST- 2024/05/23 23:50 [entrez] PHST- 2024/05/23 00:00 [pmc-release] AID - 10.1186/s12885-024-12375-7 [pii] AID - 12375 [pii] AID - 10.1186/s12885-024-12375-7 [doi] PST - epublish SO - BMC Cancer. 2024 May 23;24(1):630. doi: 10.1186/s12885-024-12375-7. PMID- 38778083 OWN - NLM STAT- MEDLINE DCOM- 20240522 LR - 20240525 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 May 22 TI - The associations between plant-based dietary indices with depression and quality of life and insomnia among Iranian adolescent girls in 2015. PG - 11683 LID - 10.1038/s41598-024-61952-0 [doi] LID - 11683 AB - Although previous research has explored the link between plant-based diets and mental health outcomes, there has been limited study on the quality levels of plant foods in this context. This study was conducted on 733 adolescent girls from cities in northeastern Iran. The validated Iranian version of the Insomnia Severity Index, SF-12v2 questionnaire and Persian version of the Beck Depression Inventory used to assess insomnia and poor quality of life (QoL) and depression, respectively. Dietary intakes assessed using a valid and reliable food frequency questionnaire. The association of scores of plant based dietary index (PDI) and poor QoL, depression and insomnia explored by binary logistic regression. The unadjusted model showed subjects in the highest quartile of healthy PDI had lower chances of insomnia than those in the lowest quartile (OR: 0.50; 95% CI 0.27-0.91, P = 0.024). The association persisted across various adjusted models. Subjects in the highest quartile of unhealthy PDI (uPDI) had higher chances of depression than those in the lowest quartile (OR: 1.83; 95% CI 1.09-3.08, P = 0.022). The significance of the association was maintained after adjusting for other confounders. A healthy plant-based dietary index is associated with a lower odds of insomnia. An unhealthy plant-based dietary index was associated to an increased chance of depression. Findings need to be confirmed by future studies. CI - (c) 2024. The Author(s). FAU - Vasmehjani, Azam Ahmadi AU - Vasmehjani AA AD - Research Center for Food Hygiene and Safety, School of Public Health Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. FAU - Darabi, Zahra AU - Darabi Z AD - Research Center for Food Hygiene and Safety, School of Public Health Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran. FAU - Ghayour-Mobarhan, Majid AU - Ghayour-Mobarhan M AD - International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Ferns, Gordon A AU - Ferns GA AD - Division of Medical Education, Brighton & Sussex Medical School, Falmer, Brighton, Sussex, BN1 9PH, UK. FAU - Khayyatzadeh, Sayyed Saeid AU - Khayyatzadeh SS AUID- ORCID: 0000-0002-9133-7340 AD - Research Center for Food Hygiene and Safety, School of Public Health Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Khayyatzadeh@yahoo.com. AD - Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Khayyatzadeh@yahoo.com. LA - eng PT - Journal Article DEP - 20240522 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Adolescent MH - Iran/epidemiology MH - *Sleep Initiation and Maintenance Disorders/epidemiology/psychology MH - *Depression/epidemiology MH - *Quality of Life MH - Surveys and Questionnaires MH - Diet, Vegetarian/psychology PMC - PMC11111745 OTO - NOTNLM OT - Adolescents OT - Depression OT - Plant-based diet index OT - Quality of life OT - Sleep COIS- The authors declare no competing interests. EDAT- 2024/05/23 00:42 MHDA- 2024/05/23 00:43 PMCR- 2024/05/22 CRDT- 2024/05/22 23:30 PHST- 2023/10/11 00:00 [received] PHST- 2024/05/12 00:00 [accepted] PHST- 2024/05/23 00:43 [medline] PHST- 2024/05/23 00:42 [pubmed] PHST- 2024/05/22 23:30 [entrez] PHST- 2024/05/22 00:00 [pmc-release] AID - 10.1038/s41598-024-61952-0 [pii] AID - 61952 [pii] AID - 10.1038/s41598-024-61952-0 [doi] PST - epublish SO - Sci Rep. 2024 May 22;14(1):11683. doi: 10.1038/s41598-024-61952-0. PMID- 38776727 OWN - NLM STAT- MEDLINE DCOM- 20240614 LR - 20260622 IS - 1872-6232 (Electronic) IS - 0378-3782 (Linking) VI - 194 DP - 2024 Jul TI - Effect of a lifestyle intervention among pregnant women with overweight on neonatal adiposity: A randomized controlled clinical trial. PG - 106038 LID - S0378-3782(24)00107-5 [pii] LID - 10.1016/j.earlhumdev.2024.106038 [doi] AB - BACKGROUND: The excess neonatal adiposity is considered a risk factor for the development of childhood obesity and the birth weight is a marker of health throughout life. AIMS: To evaluate the effect of a lifestyle intervention conducted among pregnant women with overweight on neonatal adiposity and birth weight. METHODS: A total of 350 pregnant women were recruited and randomly allocated into the control (CG) and intervention (IG) groups. Pregnant women in the IG were invited to participate in three nutritional counselling sessions based on encouraging the consumption of unprocessed and minimally processed foods, rather than ultra-processed foods, following the NOVA food classification system, which categorizes foods according to the extent and purpose of industrial processing, and the regular practice of physical activity. Neonatal adiposity was estimated using a previously validated anthropometric model. Adjusted linear regression models were used to measure the effect. RESULTS: Adopting the modified intention-to-treat principle, data from 256 neonates were analyzed for birth weight, and data from 163 for body composition estimation. The treatment had no effect on the proportion of fat mass [beta 0.52 (95 % CI -1.03, 2.06); p = .51], fat-free mass [beta -0.50 (95 % CI -2.45, 1.45); p = .61] or birth weight [beta 53.23 (95 % CI -87.19, 193.64); p = .46]. CONCLUSIONS: In the present study, the lifestyle counselling used had no effect on neonatal adiposity or birth weight. Future studies should investigate the effect of more intensive interventions. CI - Copyright (c) 2024 Elsevier B.V. All rights reserved. FAU - Baroni, Naiara Franco AU - Baroni NF AD - Postgraduate Program in Public Health, Ribeirao Preto Medical School, University of Sao Paulo. Ribeirao Preto, SP, Brazil. FAU - Carvalho, Mariana Rinaldi AU - Carvalho MR AD - Postgraduate Program in Public Health, Ribeirao Preto Medical School, University of Sao Paulo. Ribeirao Preto, SP, Brazil. FAU - da Silva Santos, Izabela AU - da Silva Santos I AD - Postgraduate Program in Nutrition and Metabolism, Ribeirao Preto Medical School, University of Sao Paulo. Ribeirao Preto, SP, Brazil. FAU - Chaves, Ana Vitoria Lanzoni AU - Chaves AVL AD - Postgraduate Program in Public Health, Ribeirao Preto Medical School, University of Sao Paulo. Ribeirao Preto, SP, Brazil. FAU - de Andrade Miranda, Daniela Elias Goulart AU - de Andrade Miranda DEG AD - University of Ribeirao Preto, Ribeirao Preto, SP, Brazil. FAU - Crivellenti, Livia Castro AU - Crivellenti LC AD - Postgraduate Program in Public Health, Ribeirao Preto Medical School, University of Sao Paulo. Ribeirao Preto, SP, Brazil. FAU - Sartorelli, Daniela Saes AU - Sartorelli DS AD - Department of Social Medicine, Ribeirao Preto Medical School, University of Sao Paulo. Ribeirao Preto, SP, Brazil. Electronic address: daniss@fmrp.usp.br. LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20240512 PL - Ireland TA - Early Hum Dev JT - Early human development JID - 7708381 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Infant, Newborn MH - *Adiposity MH - Adult MH - *Overweight/therapy MH - *Birth Weight MH - Life Style MH - Exercise MH - Pregnancy Complications/therapy OTO - NOTNLM OT - Adiposity OT - Birth weight OT - NOVA food classification OT - Neonate OT - Pregnant women OT - Randomized controlled trial COIS- Declaration of competing interest None. EDAT- 2024/05/23 00:42 MHDA- 2024/06/15 10:44 CRDT- 2024/05/22 18:08 PHST- 2024/04/08 00:00 [received] PHST- 2024/05/08 00:00 [revised] PHST- 2024/05/11 00:00 [accepted] PHST- 2024/06/15 10:44 [medline] PHST- 2024/05/23 00:42 [pubmed] PHST- 2024/05/22 18:08 [entrez] AID - S0378-3782(24)00107-5 [pii] AID - 10.1016/j.earlhumdev.2024.106038 [doi] PST - ppublish SO - Early Hum Dev. 2024 Jul;194:106038. doi: 10.1016/j.earlhumdev.2024.106038. Epub 2024 May 12. PMID- 38773444 OWN - NLM STAT- MEDLINE DCOM- 20240522 LR - 20250102 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 May 21 TI - New sagittal abdominal diameter and transverse abdominal diameter based equations to estimate visceral fat area in type 2 diabetes patients. PG - 1364 LID - 10.1186/s12889-024-18659-8 [doi] LID - 1364 AB - OBJECTIVE: Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) are considered gold standards for measuring visceral fat area (VFA). However, their relatively high prices and potential radiation exposure limit their widespread use in clinical practice and everyday life. Therefore, our study aims to develop a VFA estimated equation based on sagittal abdominal diameter (SAD) and transverse abdominal diameter (TAD) using anthropometric indexes. To the best of our knowledge, there have been limited studies investigating this aspect thus far. METHODS: This study was designed as a cross-sectional, retrospective cohort survey. A total of 288 patients (167 males and 121 females) aged 18-80 with type 2 diabetes (T2D) were consecutively collected from a multicenter hospital, and VFA was measured by CT. Subsequently, variables highly correlated with VFA were screened through general linear correlation analysis. A stepwise regression analysis was then conducted to develop a VFA estimated equation. Discrepancies between the estimated and actual VFA values were assessed using the Bland-Altman method to validate the accuracy of the equation. RESULTS: In the female T2D population, triglyceride (TG), SAD, TAD were found to be independently correlated with VFA; in the male T2D population, BMI, TG, SAD and TAD showed independent correlations with VFA. Among these variables, SAD exhibited the strongest correlation with VFA (r = 0.83 for females, r = 0.88 for males), followed by TAD (r = 0.69 for females, r = 0.79 for males). Based on these findings, a VFA estimated equation was developed for the T2D population: VFA (male) =-364.16 + 15.36*SAD + 0.77*TG + 9.41*TAD - 5.00*BMI (R(2) = 0.75, adjusted R(2) = 0.74); VFA(female)=-170.87 + 9.72*SAD-24.29*(TG;-1) + 3.93*TAD (R(2) = 0.69, adjusted R(2) = 0.68). Both models demonstrated a good fit. The Bland-Altman plot indicated a strong agreement between the actual VFA values and the estimated values, the mean differences were close to 0, and the majority of differences fell within the 95% confidence interval. CONCLUSIONS: In the T2D population, a VFA estimated equation is developed by incorporating SAD and TAD along with other measurement indices. This equation demonstrates a favorable estimated performance, suggesting to the development of novel and practical VFA estimation models in the future study. CI - (c) 2024. The Author(s). FAU - Li, Chao AU - Li C AD - Guangdong Medical University, Zhanjiang, 524001, China. FAU - Zeng, Liankun AU - Zeng L AD - Department of Endocrinology, the Fourth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511300, China. FAU - Li, Miaosheng AU - Li M AD - Department of Joint surgery, Affiliated Southwest Hospital of Youjiang Medical University for Nationalities, Baise, 533099, China. AD - Baise People's Hospital, Baise, 533099, China. FAU - Deng, Kang AU - Deng K AD - Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524002, China. FAU - Zhou, Die AU - Zhou D AD - Department of Clinical Laboratory, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510220, China. FAU - Liang, Rutao AU - Liang R AD - Guangdong Medical University, Zhanjiang, 524001, China. FAU - Zhang, Xiaoshu AU - Zhang X AD - Department of Radiology, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510220, China. FAU - Hu, Zhihui AU - Hu Z AD - Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524002, China. FAU - Luo, Ai AU - Luo A AD - Department of Endocrinology, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510220, China. FAU - Chen, Chunling AU - Chen C AD - Guangdong Medical University, Zhanjiang, 524001, China. FAU - Chen, Qi AU - Chen Q AD - Guangdong Medical University, Zhanjiang, 524001, China. FAU - Wei, Wenlong AU - Wei W AD - Guangzhou Red Cross Hospital(Guangzhou Red Cross Hospital of Jinan University), Guangzhou, 510240, China. FAU - Li, Wangen AU - Li W AD - Department of Endocrinology, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510220, China. liwg660@126.com. AD - Guangzhou Medical University, Guangzhou, 510220, China. liwg660@126.com. FAU - Hu, Zhuoqing AU - Hu Z AD - Department of Endocrinology, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510220, China. hzq7744@163.com. AD - Guangzhou Medical University, Guangzhou, 510220, China. hzq7744@163.com. LA - eng GR - 2024A03J0944/Guangzhou Science and Technology Planning Project/ GR - none/Plan on enhancing scientific research in GMU/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240521 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - Cross-Sectional Studies MH - *Diabetes Mellitus, Type 2 MH - *Intra-Abdominal Fat/diagnostic imaging MH - Retrospective Studies MH - Sagittal Abdominal Diameter MH - Tomography, X-Ray Computed PMC - PMC11106903 OTO - NOTNLM OT - Sagittal abdominal diameter (SAD) OT - Transverse abdominal diameter (TAD) OT - Type 2 diabetes OT - Visceral fat area (VFA) COIS- The authors declare no competing interests. EDAT- 2024/05/22 01:52 MHDA- 2024/05/22 06:42 PMCR- 2024/05/21 CRDT- 2024/05/21 23:52 PHST- 2023/11/02 00:00 [received] PHST- 2024/04/18 00:00 [accepted] PHST- 2024/05/22 06:42 [medline] PHST- 2024/05/22 01:52 [pubmed] PHST- 2024/05/21 23:52 [entrez] PHST- 2024/05/21 00:00 [pmc-release] AID - 10.1186/s12889-024-18659-8 [pii] AID - 18659 [pii] AID - 10.1186/s12889-024-18659-8 [doi] PST - epublish SO - BMC Public Health. 2024 May 21;24(1):1364. doi: 10.1186/s12889-024-18659-8. PMID- 38770798 OWN - NLM STAT- MEDLINE DCOM- 20240618 LR - 20240923 IS - 1543-5237 (Electronic) IS - 0367-0244 (Linking) VI - 63 IP - 4 DP - 2024 Jul-Aug TI - Maternal Feeding Practices of Children One to Three Years in Collins Chabane Municipality of South Africa. PG - 281-303 LID - 10.1080/03670244.2024.2354691 [doi] AB - The aim was to assess maternal feeding practices of children one to three years. A descriptive observational design was employed. The sample consisted of mothers-child dyads. A validated structured questionnaire was used. Data was analyzed using SPSS version 26.0. The nutrition status of the children at birth indicated 11.6% underweight as compared to the time of the study (7.2%), 7.9% were stunted increased to 38.0%, while wasting decreased from 11.4%-2.4%. Early cessation of breastfeeding and inappropriate complementary feeding practices were the factors influencing growth. The prevalence of underweight and wasting were low while stunting and overweight were high. FAU - Mbhenyane, Xikombiso AU - Mbhenyane X AUID- ORCID: 0000-0003-0408-9586 AD - Division Human Nutrition, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. FAU - Kgatle, Motlatso AU - Kgatle M AD - Department of Nutrition, School of Health Sciences, University of Venda, Thohoyandou, South Africa. FAU - Tambe, Ayuk AU - Tambe A AUID- ORCID: 0000-0002-5023-4273 AD - Division Human Nutrition, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. FAU - Mushaphi, Fhumudzani AU - Mushaphi F AUID- ORCID: 0000-0001-8148-6118 AD - Department of Nutrition, School of Health Sciences, University of Venda, Thohoyandou, South Africa. LA - eng PT - Journal Article PT - Observational Study DEP - 20240521 PL - United States TA - Ecol Food Nutr JT - Ecology of food and nutrition JID - 0315073 SB - IM MH - Humans MH - Female MH - South Africa/epidemiology MH - *Breast Feeding MH - Child, Preschool MH - Infant MH - Male MH - *Mothers MH - *Nutritional Status MH - *Thinness/epidemiology MH - *Infant Nutritional Physiological Phenomena MH - Adult MH - Growth Disorders/epidemiology MH - Overweight/epidemiology MH - Surveys and Questionnaires MH - Feeding Behavior MH - Prevalence MH - Wasting Syndrome/epidemiology OTO - NOTNLM OT - Children one to three years OT - South Africa OT - growth OT - maternal feeding practices EDAT- 2024/05/21 12:45 MHDA- 2024/06/18 18:42 CRDT- 2024/05/21 06:43 PHST- 2024/06/18 18:42 [medline] PHST- 2024/05/21 12:45 [pubmed] PHST- 2024/05/21 06:43 [entrez] AID - 10.1080/03670244.2024.2354691 [doi] PST - ppublish SO - Ecol Food Nutr. 2024 Jul-Aug;63(4):281-303. doi: 10.1080/03670244.2024.2354691. Epub 2024 May 21. PMID- 38770452 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240522 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 16 IP - 4 DP - 2024 Apr TI - Prevalence and Assessment of Factors Associated With Malnutrition in Children Residing in Slums of Mumbai: A Cross-Sectional Study. PG - e58619 LID - 10.7759/cureus.58619 [doi] LID - e58619 AB - Background Malnutrition in children continues to be a serious public health problem in India. Therefore, this study aims to evaluate the prevalence of malnutrition and assess factors contributing to it in children of the marginalized slum population of India, masked in the metropolitan cities. Methods A retrospective data analysis with a cross-sectional model was conducted by medical volunteers affiliated with the Rotaract Club of Medicrew who had organized a free pediatric health check-up camp in the Dharavi village of Mumbai, India for children under five. Children under five years of age group of either sex residing in the slums of Dharavi and whose parents consented are included in the study. Neonates, children older than five years of age, and children whose parents did not consent for them to be included in the study were excluded. A pretested, pre-validated questionnaire was administered, and statistical analysis was done with p-values <0.05 considered to be statistically significant. Results A total of 126 children were included. Out of these children, 109 of them (86.50%) had a mid-arm circumference of more than 12.5 cm (normal), 11 (8.73%) were between 11.5 cm and 12.5 cm (moderate acute malnutrition), and five (4.77%) were less than 11.5 cm (severe acute malnutrition). Among the 126 kids, 86 kids were above the age of two and their BMI was assessed, 36 (44.19%) were found to be underweight (<5th percentile) while 14 (16.3%) were obese (>95th percentile), and four (4.65%) were overweight (85th-95th percentile). For 106 (84.13%) of these children, the caregivers were mothers while others were fathers (n=4; 3.18%), grandmothers (n=5; 3.97%), sisters (n=5; 3.97%), and aunts (n=6; 4.76%). Out of those who had commenced receiving formal education, only 39 (55.71%) were in an appropriate grade for their age. The mean expenditure on food as a proportion of the total household income was 36.40% (standard deviation (SD) 15.0%). On the single-item sleep quality scale, the sleep of only 36 kids (28.58%) was reported by their caregivers as excellent. A high proportion of other medical problems were reported in the children. Conclusion Our study reports a substantial burden of malnutrition among children residing in the slums of Dharavi. Rigorous strengthening and conceptualization of on-ground nutritional programs targeted toward slum children should be done by Indian healthcare policymakers. CI - Copyright (c) 2024, Kumar et al. FAU - Kumar, Pratyush AU - Kumar P AD - Department of Medicine, Dr Baba Saheb Ambedkar Medical College and Hospital, Delhi, IND. FAU - Abhishek, Kumar AU - Abhishek K AD - Department of Medicine, Dr Baba Saheb Ambedkar Medical College and Hospital, Delhi, IND. FAU - Shukla, Rushikesh AU - Shukla R AD - Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND. FAU - Sarkar, Manali AU - Sarkar M AD - Department of Internal Medicine, MGM Medical College, Navi Mumbai, IND. FAU - Kaushal, G P AU - Kaushal GP AD - Department of Pediatrics, Dr Baba Saheb Ambedkar Medical College and Hospital, Delhi, IND. FAU - Gharde, Pankaj AU - Gharde P AD - Department of General Surgery, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND. FAU - Shah, Urmil AU - Shah U AD - Department of Medicine, Rajiv Gandhi Medical College and Chhatrapati Shivaji Maharaj Hospital, Mumbai, IND. FAU - Panchawagh, Suhrud AU - Panchawagh S AD - Department of Medicine, Smt. Kashibai Navale Medical College and General Hospital, Pune, IND. FAU - Srikumar, Shabarini AU - Srikumar S AD - Department of Internal Medicine, Tirunelveli Medical College, Tirunelveli, IND. LA - eng PT - Journal Article DEP - 20240419 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC11103267 OTO - NOTNLM OT - child health OT - india OT - malnutrition OT - mumbai OT - slums OT - under 5 age group COIS- The authors have declared that no competing interests exist. EDAT- 2024/05/21 06:44 MHDA- 2024/05/21 06:45 PMCR- 2024/04/19 CRDT- 2024/05/21 03:46 PHST- 2023/10/24 00:00 [received] PHST- 2024/04/19 00:00 [accepted] PHST- 2024/05/21 06:45 [medline] PHST- 2024/05/21 06:44 [pubmed] PHST- 2024/05/21 03:46 [entrez] PHST- 2024/04/19 00:00 [pmc-release] AID - 10.7759/cureus.58619 [doi] PST - epublish SO - Cureus. 2024 Apr 19;16(4):e58619. doi: 10.7759/cureus.58619. eCollection 2024 Apr. PMID- 38770248 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240522 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 15 DP - 2024 TI - Artistic sports activities effectiveness for enhancing students' academic performance among left-behind children: mediating effects of loneliness. PG - 1366501 LID - 10.3389/fpsyg.2024.1366501 [doi] LID - 1366501 AB - INTRODUCTION: Numerous studies within the school and academic contexts have underscored the profound impact of psychometric variables such as academic self-efficacy, self-esteem, and loneliness on academic achievement among children. Although physical activities and dance practices are known to bolster academic self-efficacy and enhance academic outcomes, the effect of Artistic Sports Activities on these psychological determinants among left-behind children (LBC) in rural schools remains underexplored. METHOD: This study was conducted from September 2020 to January 2022 among 405 LBCs aged 9 to 13 from six randomly selected primary schools in Hunan Province, China. Schools were chosen in collaboration with the Hunan Women and Children's Federation, ensuring informed consent through stakeholder informational sessions. The study employed rigorous sampling and data analysis methods, including the Shapiro-Wilk test for normal distribution and Cronbach's alpha for reliability, alongside Pearson correlation, independent and paired t-tests, and multiple linear regression analyses to investigate the effects of Artistic Sports Activities on psychometric variables and academic performance among LBCs. Data collection involved standardized questionnaires assessing academic self-efficacy, self-esteem, and loneliness before and after intervention. RESULTS: Findings indicate that Artistic Sports Activities significantly improved academic self-efficacy and self-esteem and reduced loneliness, leading to enhanced academic performance. Notably, loneliness was identified as mediating the relationship between academic self-efficacy and self-esteem among LBCs. DISCUSSION: The findings highlight the critical role of integrating Artistic Sports Activities in educational frameworks to bolster psychological and academic outcomes for LBCs. The study reveals the intricate interplay between loneliness, self-esteem, and academic self-efficacy, underscoring the necessity for targeted educational interventions. CI - Copyright (c) 2024 Zhou, Ferraro and Fan. FAU - Zhou, Yutao AU - Zhou Y AD - Physical Education Institute, Hunan University of Technology, Zhuzhou, China. AD - Hunan Research Centre for Excellence in Fitness, Health and Performance, Zhuzhou, China. FAU - Ferraro, Francesco Vincenzo AU - Ferraro FV AD - Hunan Research Centre for Excellence in Fitness, Health and Performance, Zhuzhou, China. AD - School of Human Sciences, University of Derby, Derby, United Kingdom. FAU - Fan, Chengwen AU - Fan C AD - Physical Education Institute, Hunan University of Technology, Zhuzhou, China. AD - Hunan Research Centre for Excellence in Fitness, Health and Performance, Zhuzhou, China. LA - eng PT - Journal Article DEP - 20240506 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC11104499 OTO - NOTNLM OT - academic performance OT - artistic sports activities OT - left-behind children OT - loneliness OT - self-esteem OT - student's academic self-efficacy COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/05/21 06:44 MHDA- 2024/05/21 06:45 PMCR- 2024/05/06 CRDT- 2024/05/21 03:42 PHST- 2024/01/06 00:00 [received] PHST- 2024/04/22 00:00 [accepted] PHST- 2024/05/21 06:45 [medline] PHST- 2024/05/21 06:44 [pubmed] PHST- 2024/05/21 03:42 [entrez] PHST- 2024/05/06 00:00 [pmc-release] AID - 10.3389/fpsyg.2024.1366501 [doi] PST - epublish SO - Front Psychol. 2024 May 6;15:1366501. doi: 10.3389/fpsyg.2024.1366501. eCollection 2024. PMID- 38769328 OWN - NLM STAT- MEDLINE DCOM- 20240520 LR - 20240523 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 May 20 TI - Validity and reliability of the Persian version of food preferences questionnaire (Persian-FPQ) in Iranian adolescents. PG - 11493 LID - 10.1038/s41598-024-61433-4 [doi] LID - 11493 AB - The assessment of dietary intakes and habits using reliable and youth-specific measurement tools during adolescence is essential. The aim of the present study was to culturally adapt and investigate the psychometric properties of the Persian version of the food preferences questionnaire (Persian-FPQ) among Iranian adolescents. This methodological cross-sectional study was conducted among 452 Persian-speaking adolescents, living in Isfahan, Iran. Translation of the FPQ was performed using forward-backward method. Intra Class Correlation (ICC) and Cronbach's alpha were used to assess test-retest reliability and internal consistency, respectively. Construct validity was investigated by using exploratory factor analysis (EFA). Divergent validity was determined using correlation analysis with Kessler Psychological Distress Scale (K-10). Known-group validity was assessed based on differences in mean food preference score between boys and girls and different categories of body mass index (BMI). The internal and external reliabilities for the Persian-FPQ were in the range of good to excellent in all domains (Cronbach's alpha: 0.76-0.96 and ICCs: 0.982-0.998). Boys had higher scores of food preferences than girls, indicating good known-group validity. Construct validity evaluated by EFA led to extraction of seven factors ("Vegetables", "Fruit", "Dairy", "Snacks", "Meat/Fish", "Starches" and "Miscellaneous foods"), explaining 37.8% of the variance. Divergent validity revealed significant negative correlations between five sub-scales of the Persian-FPQ and psychological distress. The Persian version of the FPQ is a reliable and valid instrument with applicability in a broad range of the population of Persian-speaking adolescents for assessing food preferences in community-based research projects. CI - (c) 2024. The Author(s). FAU - Heidari, Zahra AU - Heidari Z AD - Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Hezar-Jerib Ave., P.O. Box 319, Isfahan, 81746-3461, Iran. FAU - Feizi, Awat AU - Feizi A AUID- ORCID: 0000-0002-1930-0340 AD - Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Hezar-Jerib Ave., P.O. Box 319, Isfahan, 81746-3461, Iran. Awat_feiz@hlth.mui.ac.ir. FAU - Haghighatdoost, Fahimeh AU - Haghighatdoost F AD - Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. LA - eng GR - 982938/National Institute for Medical Research Development/ PT - Journal Article PT - Validation Study DEP - 20240520 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - Iran MH - *Food Preferences/psychology MH - Surveys and Questionnaires MH - Reproducibility of Results MH - Cross-Sectional Studies MH - *Psychometrics/methods MH - Feeding Behavior/psychology PMC - PMC11106254 OTO - NOTNLM OT - Adolescence OT - Food preferences OT - Psychometrics OT - Reliability OT - Validity COIS- The authors declare no competing interests. EDAT- 2024/05/21 00:42 MHDA- 2024/05/21 00:43 PMCR- 2024/05/20 CRDT- 2024/05/20 23:27 PHST- 2023/10/22 00:00 [received] PHST- 2024/05/06 00:00 [accepted] PHST- 2024/05/21 00:43 [medline] PHST- 2024/05/21 00:42 [pubmed] PHST- 2024/05/20 23:27 [entrez] PHST- 2024/05/20 00:00 [pmc-release] AID - 10.1038/s41598-024-61433-4 [pii] AID - 61433 [pii] AID - 10.1038/s41598-024-61433-4 [doi] PST - epublish SO - Sci Rep. 2024 May 20;14(1):11493. doi: 10.1038/s41598-024-61433-4. PMID- 38768244 OWN - NLM STAT- MEDLINE DCOM- 20240520 LR - 20260812 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 5 DP - 2024 TI - A cross-sectional study on adult lifestyle habits during the COVID-19 pandemic. PG - e0299668 LID - 10.1371/journal.pone.0299668 [doi] LID - e0299668 AB - COVID-19 has spread and developed into a pandemic disease, forcing countries to impose challenging protocols and lockdowns. This study assessed shopping, food consumption behavior, and feelings in Jordan and several Arab countries during the COVID-19 pandemic. A cross-sectional web-based survey among the Middle East population was conducted using an online questionnaire between July and September 2022. Participants were requested to answer a standardized and validated structured questionnaire. Demographic information, shopping behavior information, and mental health data were requested. A total of 542 respondents were included in the study. During COVID-19 quarantine, participants (68.6%) reported decreased shopping frequency and buying more food than usual (37.5%). Cereals and legumes were the primary food types stored by participants (76.9%). Multiple logistic regression revealed the age of the participant as a significant factor affecting storing of food (being .000. Younger participants took more bites, chewed more times and swallowed more frequently with longer chewing and swallowing time. Boys exhibited a lower number of swallows, shorter swallow time and reduced total masticatory time at p > .05. Additionally, girls demonstrated fewer bites and chewing cycles compared to boys at p > .05. CONCLUSION: TOMASS-C using a validated regional cracker was feasible and reliable. Normative data established for healthy boys and girls between 6-20 years offers much-needed quantitative data to objectively delineate individuals with and without chewing and swallowing solid food difficulties. CI - (c) 2024 The Authors. Journal of Oral Rehabilitation published by John Wiley & Sons Ltd. FAU - Aseef, Ambreen AU - Aseef A AD - Department of Audiology and Speech Language Pathology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Karnataka, Manipal, India. FAU - Dodderi, Thejaswi AU - Dodderi T AUID- ORCID: 0000-0002-8758-5122 AD - Department of Audiology and Speech Language Pathology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Karnataka, Manipal, India. FAU - Muthukumar, Varsha AU - Muthukumar V AD - Department of Audiology and Speech Language Pathology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Karnataka, Manipal, India. FAU - Krishnamurthy, Rahul AU - Krishnamurthy R AUID- ORCID: 0000-0003-1736-1737 AD - Special Education and Communication Disorders (SECD), University of Nebraska-Lincoln, Lincoln, USA. FAU - Balasubramanium, Radish Kumar AU - Balasubramanium RK AUID- ORCID: 0000-0001-6485-4644 AD - Department of Audiology and Speech Language Pathology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Karnataka, Manipal, India. FAU - Kothari, Mohit AU - Kothari M AUID- ORCID: 0000-0002-8191-9769 AD - Department of Audiology and Speech Language Pathology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Karnataka, Manipal, India. AD - Hammel Neurorehabilitation Center and University Research Clinic, Department of Clinical Medicine, Aarhus University, Hammel, Denmark. LA - eng PT - Journal Article DEP - 20240520 PL - England TA - J Oral Rehabil JT - Journal of oral rehabilitation JID - 0433604 SB - IM MH - Humans MH - *Deglutition/physiology MH - *Mastication/physiology MH - Female MH - Male MH - Adolescent MH - Cross-Sectional Studies MH - Young Adult MH - Child MH - India MH - Reproducibility of Results MH - *Video Recording MH - Reference Values MH - Healthy Volunteers OTO - NOTNLM OT - TOMASS OT - TOMASS-C OT - chewing OT - deglutition OT - mastication OT - swallowing EDAT- 2024/05/20 12:42 MHDA- 2024/08/13 06:42 CRDT- 2024/05/20 06:13 PHST- 2024/04/30 00:00 [revised] PHST- 2023/04/17 00:00 [received] PHST- 2024/05/06 00:00 [accepted] PHST- 2024/08/13 06:42 [medline] PHST- 2024/05/20 12:42 [pubmed] PHST- 2024/05/20 06:13 [entrez] AID - 10.1111/joor.13741 [doi] PST - ppublish SO - J Oral Rehabil. 2024 Sep;51(9):1839-1847. doi: 10.1111/joor.13741. Epub 2024 May 20. PMID- 38765486 OWN - NLM STAT- MEDLINE DCOM- 20240520 LR - 20261026 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 12 DP - 2024 TI - Influence of physical exercise on negative emotions in college students: chain mediating role of sleep quality and self-rated health. PG - 1402801 LID - 10.3389/fpubh.2024.1402801 [doi] LID - 1402801 AB - BACKGROUND: Negative emotions in college students are a significant factor affecting mental health, with suicide behaviors caused by negative emotions showing an annual increasing trend. Existing studies suggest that physical exercise is essential to alleviate negative feelings, yet the intrinsic mechanisms by which it affects negative emotions have not been fully revealed. OBJECTIVE: Negative emotions in college students represent a significant issue affecting mental health. This study investigates the relationship between physical exercise and negative emotions among college students, incorporating sleep quality and self-rated health (SRH) as mediators to analyze the pathway mechanism of how physical exercise affects students' negative emotions. METHODS: A cross-sectional study design was utilized, employing online questionnaires for investigation. The scales included the Physical Activity Rating Scale-3 (PARS-3), the Depression Anxiety Stress Scales-21 (DASS-21), the Pittsburgh Sleep Quality Index (PSQI), and the 12-Item Short Form Health Survey (SF-12), resulting in the collection of 30,475 valid questionnaires, with a validity rate of 91%. Chain mediation tests and Bootstrap methods were applied for effect analysis. RESULTS: The proportions of university students engaged in low, medium, and high levels of physical exercise were 77.6, 13.1, and 9.3%, respectively. The proportions of students experiencing "very severe" levels of stress, anxiety, and depression were 4.5, 10.9, and 3.6%, respectively. Physical exercise was significantly positively correlated with self-rated health (r = 0.194, p < 0.01), significantly negatively correlated with sleep quality (r = -0.035, p < 0.01), and significantly negatively correlated with stress, anxiety, and depression (r = -0.03, p < 0.01; r = -0.058, p < 0.01; r = -0.055, p < 0.01). Sleep quality was significantly negatively correlated with self-rated health (r = -0.242, p < 0.01). Mediation effect testing indicated that sleep quality and self-rated health partially mediated the relationship between physical exercise and negative emotions, with total effect, total direct effect, and total indirect effect values of -1.702, -0.426, and - 1.277, respectively. CONCLUSION: College students primarily engage in low-intensity physical activity. Sleep quality and self-rated health mediate the impact of physical exercise on students' negative emotions. A certain level of physical activity can directly affect students' emotional states and indirectly influence their negative emotions via sleep and self-rated health. Regular engagement in physical activities primarily positively impacts emotional states by enhancing mood stability and overall emotional resilience. CI - Copyright (c) 2024 Mu, Liu, Lou, Zhu, Wang and Li. FAU - Mu, Fan-Zheng AU - Mu FZ AD - Institute of Sports Science, Nantong University, Nantong, China. FAU - Liu, Jun AU - Liu J AD - Institute of Sports Science, Nantong University, Nantong, China. FAU - Lou, Hu AU - Lou H AD - Institute of Sports Science, Nantong University, Nantong, China. FAU - Zhu, Wei-Dong AU - Zhu WD AD - Institute of Sports Science, Nantong University, Nantong, China. FAU - Wang, Zhen-Cheng AU - Wang ZC AD - School of Basic Medicine, Nanjing Medical University, Nanjing, China. FAU - Li, Bo AU - Li B AD - Institute of Sports Science, Nantong University, Nantong, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240502 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Male MH - *Students/psychology MH - Female MH - *Exercise/psychology MH - Cross-Sectional Studies MH - Universities MH - Surveys and Questionnaires MH - *Sleep Quality MH - Young Adult MH - *Emotions/physiology MH - Adult MH - Adolescent MH - Depression/psychology MH - Health Status MH - Mental Health PMC - PMC11100322 OTO - NOTNLM OT - chain mediation model OT - college student OT - physical exercise OT - self-rated health OT - sleep quality COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/05/20 06:42 MHDA- 2024/05/20 06:43 PMCR- 2024/05/02 CRDT- 2024/05/20 04:09 PHST- 2024/03/18 00:00 [received] PHST- 2024/04/19 00:00 [accepted] PHST- 2024/05/20 06:43 [medline] PHST- 2024/05/20 06:42 [pubmed] PHST- 2024/05/20 04:09 [entrez] PHST- 2024/05/02 00:00 [pmc-release] AID - 10.3389/fpubh.2024.1402801 [doi] PST - epublish SO - Front Public Health. 2024 May 2;12:1402801. doi: 10.3389/fpubh.2024.1402801. eCollection 2024. PMID- 38765400 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240722 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 16 IP - 4 DP - 2024 Apr TI - Sugar-Sweetened Beverage Consumption and Its Association With Dental Caries Among Adolescents in Erbil, Iraq: A Cross-Sectional Study. PG - e58471 LID - 10.7759/cureus.58471 [doi] LID - e58471 AB - Background Sugar-sweetened beverages are one of the most common sources of added sugar in the diet and have been associated with an increased risk of dental caries, obesity, major chronic diseases, and possibly cancer. Dental caries is a diet-related, highly prevalent, and preventable oral disease. The objective of this study was to assess the frequency of sugar-sweetened beverage consumption and its association with dental caries in adolescents in Erbil, Iraq. Methods This is a cross-sectional study that invited 11- to 16-year-old intermediate school students (n=380) in Erbil, Iraq. Data collection comprised a validated questionnaire and a clinical examination. In addition, dietary data were collected by using two non-consecutive 24-hour recalls. The mean of the daily consumption of sugar-sweetened beverages over a two-day period was calculated. Dental caries was diagnosed based on World Health Organization (WHO) criteria and was reported as a decayed, missing, and filled permanent tooth (DMFT). A multiple regression model was used to assess the influence of sugar-sweetened beverages on dental caries experience (DMFT). SPSS version 26 (Armonk, NY: IBM Corp) was used to analyze the data at the 5% significance level. Results Of the 380 students interviewed, one participant was excluded because of incomplete data. The participant's mean age and standard deviation (SD) were 13.3+/-1.2. A total of 54.1% of the students were female. The mean daily intake of sugar-sweetened beverages was 686.71+/-197.50 mL per day. Male students consumed more beverages than female students (p<0.001). The most frequently consumed sugar-sweetened beverages were sweetened tea and coffee, and the least frequently consumed beverages were milk and dairy products. The mean decayed, missing, and filled permanent tooth (DMFT) was 94.58+/-2.73. Results of multiple regression analysis showed that caries experience (DMFT) was associated with insufficient toothbrushing (p<0.001), plaque-affected sextants (p=0.001), and male sex (p=0.016). The model also showed a significant association between sugar-sweetened beverage consumption and dental caries experience (DMFT) (regression coefficient=0.008, CI: 0.006-0.009, p<0.001). Conclusions Adolescents in Erbil, Iraq, consumed sugar-sweetened beverages on a frequent basis, and male students consumed more sugary beverages than females. The higher frequency of these beverage consumptions was associated with a higher dental caries experience. Consequently, reducing sugar-sweetened beverage consumption could have a significant positive public health impact. CI - Copyright (c) 2024, Hassan et al. FAU - Hassan, Heran I Sr AU - Hassan HI Sr AD - Orthodontics, Pediatric and Preventive Dentistry, College of Dentistry, Hawler Medical University, Erbil, IRQ. FAU - Othman, Samir M AU - Othman SM AD - Community Medicine, College of Medicine, Hawler Medical University, Erbil, IRQ. LA - eng PT - Journal Article DEP - 20240417 PL - United States TA - Cureus JT - Cureus JID - 101596737 EIN - Cureus. 2024 Jul 18;16(7):c186. doi: 10.7759/cureus.c186. PMID: 39035596 PMC - PMC11100997 OTO - NOTNLM OT - 24h recalls OT - adolescences OT - common risk factor approach OT - dental caries OT - oral health OT - public health OT - sugar-sweetened beverages COIS- The authors have declared that no competing interests exist. EDAT- 2024/05/20 06:42 MHDA- 2024/05/20 06:43 PMCR- 2024/04/17 CRDT- 2024/05/20 04:08 PHST- 2024/04/17 00:00 [accepted] PHST- 2024/05/20 06:43 [medline] PHST- 2024/05/20 06:42 [pubmed] PHST- 2024/05/20 04:08 [entrez] PHST- 2024/04/17 00:00 [pmc-release] AID - 10.7759/cureus.58471 [doi] PST - epublish SO - Cureus. 2024 Apr 17;16(4):e58471. doi: 10.7759/cureus.58471. eCollection 2024 Apr. PMID- 38763928 OWN - NLM STAT- MEDLINE DCOM- 20240905 LR - 20240910 IS - 1436-6215 (Electronic) IS - 1436-6207 (Print) IS - 1436-6207 (Linking) VI - 63 IP - 6 DP - 2024 Sep TI - Environmental impact of the diet of young Portuguese and its relationship with adherence to the Mediterranean Diet. PG - 2307-2315 LID - 10.1007/s00394-024-03396-w [doi] AB - OBJECTIVE: To estimate, in a cohort of young Portuguese adults, the environmental impact (greenhouse gas (GHG) emissions, land use, energy used, acidification and potential eutrophication) of diet according to adherence to the Mediterranean Diet (MD). METHODS: Data from 1554 participants of the Epidemiologic Health Investigation of Teenagers in Porto (EPITeen) were analysed. Food intake and MD adherence were determined using validated questionnaires. The environmental impact was evaluated with the EAT-Lancet Commission tables, and the link between MD adherence and environmental impact was calculated using adjusted multivariate linear regression models. RESULTS: Higher adherence (high vs. low) to the MD was associated with lower environmental impact in terms of land use (7.8 vs. 8.5 m(2), p = 0.002), potential acidification (57.8 vs. 62.4 g SO2-eq, p = 0.001) and eutrophication (21.7 vs. 23.5 g PO4-eq, p < 0.001). Energy use decreased only in the calorie-adjusted model (9689.5 vs. 10,265.9 kJ, p < 0.001), and GHG emissions were reduced only in a complementary model where fish consumption was eliminated (3035.3 vs. 3281.2 g CO2-eq, p < 0.001). Meat products had the greatest environmental impact for all five environmental factors analysed: 35.7% in GHG emissions, 60.9% in energy use, 72.8% in land use, 70% in acidification and 61.8% in eutrophication. CONCLUSIONS: Higher adherence to the MD is associated with lower environmental impact, particularly in terms of acidification, eutrophication, and land use. Reducing meat consumption can contribute to greater environmental sustainability. CI - (c) 2024. The Author(s). FAU - Alvarez-Alvarez, Laura AU - Alvarez-Alvarez L AD - Group of Investigation in Interactions Gene-Environment and Health (GIIGAS), Institute of Biomedicine (IBIOMED), University of Leon, Leon, Spain. FAU - Vitelli-Storelli, Facundo AU - Vitelli-Storelli F AD - Group of Investigation in Interactions Gene-Environment and Health (GIIGAS), Institute of Biomedicine (IBIOMED), University of Leon, Leon, Spain. FAU - Rubin-Garcia, Maria AU - Rubin-Garcia M AD - Group of Investigation in Interactions Gene-Environment and Health (GIIGAS), Institute of Biomedicine (IBIOMED), University of Leon, Leon, Spain. FAU - Martin-Sanchez, Vicente AU - Martin-Sanchez V AD - Group of Investigation in Interactions Gene-Environment and Health (GIIGAS), Institute of Biomedicine (IBIOMED), University of Leon, Leon, Spain. AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. FAU - Garcia Fernandez, Camino AU - Garcia Fernandez C AD - Department of Food Hygiene and Technology, Veterinary Faculty, University of Leon, Leon, Spain. FAU - Carvalho, Catarina AU - Carvalho C AD - Department of Public Health and Forensic Sciences, EPIUnit-Institute of Public Health, University of Porto, Porto, Portugal. AD - Laboratory for Integrative and Translational Research in Population Health (ITR), University of Porto, Porto, Portugal. AD - Medical School, University of Porto, Porto, Portugal. FAU - Araujo, Joana AU - Araujo J AD - Department of Public Health and Forensic Sciences, EPIUnit-Institute of Public Health, University of Porto, Porto, Portugal. AD - Laboratory for Integrative and Translational Research in Population Health (ITR), University of Porto, Porto, Portugal. AD - Medical School, University of Porto, Porto, Portugal. FAU - Ramos, Elisabete AU - Ramos E AUID- ORCID: 0000-0001-7146-3457 AD - Department of Public Health and Forensic Sciences, EPIUnit-Institute of Public Health, University of Porto, Porto, Portugal. up426486@g.uporto.pt. AD - Laboratory for Integrative and Translational Research in Population Health (ITR), University of Porto, Porto, Portugal. up426486@g.uporto.pt. AD - Medical School, University of Porto, Porto, Portugal. up426486@g.uporto.pt. LA - eng GR - PTDC/DTP-EPI/6506/2014/Portuguese Foundation for Science and Technology/ GR - UID/DTP/047507/2013/Epidemiology Research Unit - Institute of Public Health, University of Porto/ PT - Journal Article DEP - 20240519 PL - Germany TA - Eur J Nutr JT - European journal of nutrition JID - 100888704 RN - 0 (Greenhouse Gases) SB - IM MH - Humans MH - *Diet, Mediterranean/statistics & numerical data MH - Portugal MH - Female MH - Male MH - Young Adult MH - *Environment MH - Adolescent MH - Surveys and Questionnaires MH - Greenhouse Gases/analysis MH - Adult MH - Cohort Studies MH - Eutrophication MH - Patient Compliance/statistics & numerical data PMC - PMC11377495 OTO - NOTNLM OT - Climate change OT - Environmental sustainability OT - Healthy dietary pattern OT - Sustainable food COIS- The authors declare that they have no conflict of interest. EDAT- 2024/05/20 00:42 MHDA- 2024/09/05 12:44 PMCR- 2024/05/19 CRDT- 2024/05/19 23:04 PHST- 2023/12/12 00:00 [received] PHST- 2024/04/16 00:00 [accepted] PHST- 2024/09/05 12:44 [medline] PHST- 2024/05/20 00:42 [pubmed] PHST- 2024/05/19 23:04 [entrez] PHST- 2024/05/19 00:00 [pmc-release] AID - 10.1007/s00394-024-03396-w [pii] AID - 3396 [pii] AID - 10.1007/s00394-024-03396-w [doi] PST - ppublish SO - Eur J Nutr. 2024 Sep;63(6):2307-2315. doi: 10.1007/s00394-024-03396-w. Epub 2024 May 19. PMID- 38762295 OWN - NLM STAT- MEDLINE DCOM- 20240518 LR - 20260826 IS - 2214-109X (Electronic) IS - 2214-109X (Linking) VI - 12 IP - 6 DP - 2024 Jun TI - Predicting mortality within 1 year of ART initiation in children and adolescents living with HIV in sub-Saharan Africa: a retrospective observational cohort study. PG - e929-e937 LID - S2214-109X(24)00091-3 [pii] LID - 10.1016/S2214-109X(24)00091-3 [doi] AB - BACKGROUND: Differentiated service delivery (DSD) for children and adolescents living with HIV can improve targeted resource use. We derived a mortality prediction score to guide clinical decision making for children and adolescents living with HIV. METHODS: Data for this retrospective observational cohort study were evaluated for all children and adolescents living with HIV and initiating antiretroviral therapy (ART); aged 0-19 years; and enrolled at Baylor clinics in Eswatini, Malawi, Lesotho, Tanzania, and Uganda between 2005 and 2020. Data for clinical prediction, including anthropometric values, physical examination, ART, WHO stage, and laboratory tests were captured at ART initiation. Backward stepwise variable selection and logistic regression were performed to develop predictive models for mortality within 1 year of ART initiation. Probabilities of mortality were generated, compared with true outcomes, internally validated, and evaluated against WHO advanced HIV criteria. FINDINGS: The study population included 16 958 children and adolescents living with HIV and initiated on ART between May 18, 2005, and Dec 18, 2020. Predictive variables for the most accurate model included: age, CD4 percentage, white blood cell count, haemoglobin concentration, platelet count, and BMI Z score as continuous variables, and WHO clinical stage and oedema, abnormal muscle tone and respiratory distress on examination as categorical variables. The area under the curve (AUC) of the predictive model was 0.851 (95% CI 0.839-0.863) in the training set and 0.822 (0.800-0.845) in the test set, compared with 0.606 (0.595-0.617) for the WHO advanced HIV criteria (p<0.0001). INTERPRETATION: This study evaluated a large, multinational population to derive a mortality prediction tool for children and adolescents living with HIV. The model more accurately predicted clinical outcomes than the WHO advanced HIV criteria and has the potential to improve DSD for children and adolescents living with HIV in high-burden settings. FUNDING: National Institute of Health Fogarty International Center. CI - Copyright (c) 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. Published by Elsevier Ltd.. All rights reserved. FAU - Kay, Alexander AU - Kay A AD - Baylor College of Medicine, Houston, TX, USA; Baylor College of Medicine Children's Foundation-Eswatini, Mbabane, Eswatini. Electronic address: alexander.kay@bcm.edu. FAU - Lukhele, Bhekumusa AU - Lukhele B AD - Department of Health Policy and Organization, University of Alabama at Birmingham, Birmingham, AL, USA. FAU - Dlamini, Sandile AU - Dlamini S AD - Baylor College of Medicine Children's Foundation-Eswatini, Mbabane, Eswatini. FAU - Seeger, Abigail AU - Seeger A AD - Baylor College of Medicine, Houston, TX, USA. FAU - Dlamini, Phumzile AU - Dlamini P AD - Baylor College of Medicine Children's Foundation-Eswatini, Mbabane, Eswatini. FAU - Ndabezitha, Sandile AU - Ndabezitha S AD - Baylor College of Medicine Children's Foundation-Eswatini, Mbabane, Eswatini. FAU - Mthethwa, Nobuhle AU - Mthethwa N AD - Eswatini National AIDS Program, Mbabane, Eswatini. FAU - Steffy, Teresa AU - Steffy T AD - Baylor College of Medicine, Houston, TX, USA; Baylor College of Medicine Children's Foundation-Lesotho, Maseru, Lesotho. FAU - Komba, Lilian AU - Komba L AD - Baylor College of Medicine Children's Foundation-Tanzania, Mbeya and Mwanza, Tanzania. FAU - Amuge, Pauline AU - Amuge P AD - Baylor College of Medicine Children's Foundation-Uganda, Kampala, Uganda. FAU - Ketangenyi, Eunice AU - Ketangenyi E AD - Baylor College of Medicine Children's Foundation-Tanzania, Mbeya and Mwanza, Tanzania. FAU - Elyanu, Peter AU - Elyanu P AD - Baylor College of Medicine Children's Foundation-Uganda, Kampala, Uganda. FAU - Munthali, Adamson AU - Munthali A AD - Baylor College of Medicine Children's Foundation-Malawi, Lilongwe, Malawi. FAU - Msekandiana, Amos AU - Msekandiana A AD - Baylor College of Medicine Children's Foundation-Malawi, Lilongwe, Malawi. FAU - Maldonado, Yvonne AU - Maldonado Y AD - Department of Pediatrics, Stanford University, Stanford, CA, USA. FAU - Chiao, Elizabeth AU - Chiao E AD - MD Anderson Cancer Center, Houston, TX, USA. FAU - Kekitiinwa, Adeodata AU - Kekitiinwa A AD - Baylor College of Medicine, Houston, TX, USA; Baylor College of Medicine Children's Foundation-Uganda, Kampala, Uganda. FAU - Thahane, Lineo AU - Thahane L AD - Baylor College of Medicine, Houston, TX, USA; Baylor College of Medicine Children's Foundation-Lesotho, Maseru, Lesotho. FAU - Mwita, Lumumba AU - Mwita L AD - Baylor College of Medicine, Houston, TX, USA; Baylor College of Medicine Children's Foundation-Tanzania, Mbeya and Mwanza, Tanzania. FAU - Kirchner, H Lester AU - Kirchner HL AD - Baylor College of Medicine, Houston, TX, USA; Department of Population Health Sciences, Geisinger Health, Danville, VA, USA. FAU - Mandalakas, Anna Maria AU - Mandalakas AM AD - Baylor College of Medicine, Houston, TX, USA; Research Center Borstel, Sulfeld, Germany. LA - eng GR - D43 TW011547/TW/FIC NIH HHS/United States GR - K01 TW011482/TW/FIC NIH HHS/United States PT - Journal Article PT - Observational Study PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PL - England TA - Lancet Glob Health JT - The Lancet. Global health JID - 101613665 RN - 0 (Anti-HIV Agents) SB - IM MH - Humans MH - Adolescent MH - *HIV Infections/drug therapy/mortality MH - Child MH - Retrospective Studies MH - Female MH - Male MH - Child, Preschool MH - Africa South of the Sahara/epidemiology MH - Infant MH - Young Adult MH - Infant, Newborn MH - Anti-HIV Agents/therapeutic use PMC - PMC11149103 MID - NIHMS1995336 COIS- Declaration of interests We declare no competing interests. EDAT- 2024/05/19 00:42 MHDA- 2024/05/19 00:43 PMCR- 2024/06/04 CRDT- 2024/05/18 20:57 PHST- 2023/07/19 00:00 [received] PHST- 2024/01/26 00:00 [revised] PHST- 2024/02/22 00:00 [accepted] PHST- 2024/05/19 00:43 [medline] PHST- 2024/05/19 00:42 [pubmed] PHST- 2024/05/18 20:57 [entrez] PHST- 2024/06/04 00:00 [pmc-release] AID - S2214-109X(24)00091-3 [pii] AID - 10.1016/S2214-109X(24)00091-3 [doi] PST - ppublish SO - Lancet Glob Health. 2024 Jun;12(6):e929-e937. doi: 10.1016/S2214-109X(24)00091-3. PMID- 38760691 OWN - NLM STAT- MEDLINE DCOM- 20240518 LR - 20240520 IS - 1471-230X (Electronic) IS - 1471-230X (Linking) VI - 24 IP - 1 DP - 2024 May 17 TI - The association between night eating syndrome and GERD symptoms among university students at An-Najah National University in Palestine: a cross-sectional study. PG - 169 LID - 10.1186/s12876-024-03259-y [doi] LID - 169 AB - BACKGROUND: Night eating syndrome (NES) is a kind of eating disorder. NES association with gastroesophageal reflux disease (GERD) symptoms among university students is still not fully understood. We aimed to determine the relationship between NES and the presence of GERD symptoms among university students at An-Najah National University in Palestine. METHODS: This study involved undergraduate students from An-Najah National University. The data were collected through online surveys from November to December 2023. The sampling frame involved voluntary sampling, as the data were collected using a structured questionnaire to collect data on sociodemographic variables, medical history, lifestyle habits, nutritional status, GERD risk, and NES. The GERD questionnaire (GerdQ) was used to assess symptoms, while the Arabic version of the validated Night Eating Questionnaire (NEQ) was used to assess night eating. Physical activity was assessed using the short form of the International Physical Activity Questionnaire (SF-IPAQ), and adherence to a Mediterranean diet was assessed using the validated Arabic version of the MEDAS. Both univariate and multivariate analyses were also conducted to assess the study hypotheses. RESULTS: The study involved 554 participants, 59.9% female. A total of 33.4% reported GERD symptoms, with 10.3% having NES. A strong association was observed between GERD and NES and between GERD and physical activity. Night eating syndrome (AOR = 2.84, CI = 1.07-3.19), high physical activity (AOR = 0.473, CI = 1.05-3.19), and non-smoking (AOR = 0.586, CI = 1.27-7.89) were identified as independent predictors of GERD symptoms. CONCLUSION: This study revealed that 33.4% of undergraduate students were at risk of GERD, with night eaters having a greater risk. GERD risk was negatively associated with physical activity level and smoking status. No associations were found between GERD risk and weight status, Mediterranean diet adherence, sociodemographic factors, or sleep disturbances. CI - (c) 2024. The Author(s). FAU - Abed, Mohammad Taleb AU - Abed MT AD - Department of Medicine, College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine. FAU - Sayyed, Eyad AU - Sayyed E AD - Department of Medicine, College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine. FAU - Yamak, Obada AU - Yamak O AD - Department of Medicine, College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine. FAU - Abdoh, Qusay AU - Abdoh Q AD - Department of Medicine, College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine. AD - Department of Internal Medicine, GI and Endoscopy Unit, An-Najah National University Hospital, Nablus, 44839, Palestine. FAU - Badrasawi, Manal AU - Badrasawi M AD - Department of Nutrition and Food Technology, College of Medicine and Health Sciences, An- Najah National University, Nablus, 44839, Palestine. m.badrasawi@najah.edu. LA - eng PT - Journal Article DEP - 20240517 PL - England TA - BMC Gastroenterol JT - BMC gastroenterology JID - 100968547 SB - IM MH - Humans MH - *Gastroesophageal Reflux/epidemiology MH - Female MH - Male MH - Cross-Sectional Studies MH - *Students/statistics & numerical data MH - Universities MH - Young Adult MH - *Night Eating Syndrome/epidemiology MH - *Exercise MH - Surveys and Questionnaires MH - Adult MH - Diet, Mediterranean/statistics & numerical data MH - Adolescent MH - Risk Factors MH - Life Style MH - Middle East/epidemiology PMC - PMC11100070 OTO - NOTNLM OT - Gastroesophageal reflux disease (GERD) OT - Lifestyle OT - Mediterranean diet OT - Night eating syndrome (NES) OT - University students COIS- The authors declare no competing interests. EDAT- 2024/05/18 04:43 MHDA- 2024/05/18 19:44 PMCR- 2024/05/17 CRDT- 2024/05/17 23:33 PHST- 2024/01/01 00:00 [received] PHST- 2024/05/08 00:00 [accepted] PHST- 2024/05/18 19:44 [medline] PHST- 2024/05/18 04:43 [pubmed] PHST- 2024/05/17 23:33 [entrez] PHST- 2024/05/17 00:00 [pmc-release] AID - 10.1186/s12876-024-03259-y [pii] AID - 3259 [pii] AID - 10.1186/s12876-024-03259-y [doi] PST - epublish SO - BMC Gastroenterol. 2024 May 17;24(1):169. doi: 10.1186/s12876-024-03259-y. PMID- 38758024 OWN - NLM STAT- MEDLINE DCOM- 20240517 LR - 20260402 IS - 1550-5057 (Electronic) IS - 0160-6379 (Print) IS - 0160-6379 (Linking) VI - 47 IP - 3 DP - 2024 Jul-Sep 01 TI - Food Insecurity and Family Dynamics: A Systematic Review. PG - 219-230 LID - 10.1097/FCH.0000000000000401 [doi] AB - BACKGROUND: Undernutrition is related to numerous childhood outcomes. However, little research has investigated the relationship between food insecurity and family dynamics. This systematic review seeks to validate the evidence for a relationship between these 2 factors. METHODS: A systematic literature review was conducted in Embase, PubMed, and Scopus. Inclusion criteria include peer-reviewed research articles published during or after 1996 in English, using standardized measures of family function and food insecurity. Exclusion criteria include measurement of parent or child characteristics without assessing household or family characteristics or demographics. Two reviewers independently voted using Covidence, and Alpha agreement was determined at each phase. RESULTS: A total of 15 studies were included for data extraction after the initial search being completed in April 2022. All included studies were found to be appropriate in numerous categories for quality assessment. Primary findings from these studies show a potential relationship exists between food insecurity and family dynamics. DISCUSSION: The findings in this review suggest that effects of food insecurity expand to various aspects of healthy family functioning. Unhealthy family dynamics in childhood can also expose children to trauma and lead to increased physical and mental health disorders in the future. CI - Copyright (c) 2024 Wolters Kluwer Health, Inc. All rights reserved. FAU - Krishnamurthy, Sudarshan AU - Krishnamurthy S AD - Author Affiliations: Department of Internal Medicine (Mr Krishnamurthy), Department of Pediatrics (Dr Skelton), Center for Prevention Science in Child and Family Health (Dr Skelton), Wake Forest University School of Medicine (Messrs Krishnamurthy and Chait, Ms Reddy, and Mr Galli), Winston-Salem, North Carolina. FAU - Chait, Joshua S AU - Chait JS FAU - Reddy, Menaka N AU - Reddy MN FAU - Galli, Lucas D AU - Galli LD FAU - Skelton, Joseph A AU - Skelton JA LA - eng GR - P30 DK124723/DK/NIDDK NIH HHS/United States GR - UL1 TR001420/TR/NCATS NIH HHS/United States PT - Journal Article PT - Systematic Review DEP - 20240516 PL - United States TA - Fam Community Health JT - Family & community health JID - 7809641 SB - IM MH - Humans MH - *Food Insecurity MH - *Family Relations/psychology MH - Child MH - Family Characteristics PMC - PMC11104509 MID - NIHMS1972454 COIS- The authors declare no conflict of interest. EDAT- 2024/05/17 12:43 MHDA- 2024/05/17 12:44 PMCR- 2025/05/16 CRDT- 2024/05/17 09:23 PHST- 2024/05/17 12:44 [medline] PHST- 2024/05/17 12:43 [pubmed] PHST- 2024/05/17 09:23 [entrez] PHST- 2025/05/16 00:00 [pmc-release] AID - 00003727-202407000-00004 [pii] AID - 10.1097/FCH.0000000000000401 [doi] PST - ppublish SO - Fam Community Health. 2024 Jul-Sep 01;47(3):219-230. doi: 10.1097/FCH.0000000000000401. Epub 2024 May 16. PMID- 38754222 OWN - NLM STAT- MEDLINE DCOM- 20240601 LR - 20240601 IS - 1873-7358 (Electronic) IS - 1471-0153 (Linking) VI - 53 DP - 2024 Apr TI - Factor structure, group invariance, and concurrent validity of scores from the college eating and drinking behavior scale among U.S. college students. PG - 101876 LID - S1471-0153(24)00035-7 [pii] LID - 10.1016/j.eatbeh.2024.101876 [doi] AB - Food and alcohol disturbance (FAD) refers to the intersection of alcohol- and eating-related motives and behaviors, such as restricting food intake before or during alcohol use to offset caloric intake or to enhance intoxication. Valid assessment is critical for advancing research on FAD. We tested the factor structure, group invariance, and concurrent validity of the College Eating and Drinking Behavior Scale (CEDBS) in a large college student sample (n = 2610; Mage = 20.95, SD = 4.65; 71.8% female; 77% White; 86% non-Hispanic). Participants completed measures assessing antecedents of alcohol use (i.e., protective behavioral strategies and drinking motives), negative alcohol-related consequences, alcohol use severity, and risk for eating disorder. The 3-factor model of the 21-item CEDBS provided an adequate fit to the data (e.g., CFI = 0.916). These factors include Alternative Methods (4 items; "Use laxative prior to drinking alcohol"), Offset Calories (7 items; "Restrict calories prior to drinking to help maintain your figure"), and Quicker Intoxication (10 items; "Not eating before drinking alcohol because it gives you the best buzz"). The CEDBS was scalar invariant across subgroups of participants based on age, sex, race/ethnicity, socioeconomic status, sexual orientation, and political orientation. Quicker Intoxication was most strongly related to risk factors and negative consequences for alcohol (r = 0.204-0.379, all ps < 0.01), and Offset Calories was most strongly related to risk for eating disorders (r = 0.349, p < .01). These findings further support the CEDBS to assess FAD among college students. CI - Copyright (c) 2024. Published by Elsevier Ltd. FAU - Richards, Dylan K AU - Richards DK AD - Center on Alcohol, Substance use, And Addictions (CASAA), University of New Mexico, 2650 Yale Blvd SE, Albuquerque, NM 87109, United States of America. FAU - Pearson, Matthew R AU - Pearson MR AD - Center on Alcohol, Substance use, And Addictions (CASAA), University of New Mexico, 2650 Yale Blvd SE, Albuquerque, NM 87109, United States of America. Electronic address: mateo.pearson@gmail.com. CN - Protective Strategies Study Team AD - Center on Alcohol, Substance use, And Addictions (CASAA), University of New Mexico, 2650 Yale Blvd SE, Albuquerque, NM 87109, United States of America. LA - eng PT - Journal Article DEP - 20240413 PL - United States TA - Eat Behav JT - Eating behaviors JID - 101090048 SB - IM MH - Humans MH - Female MH - Male MH - *Students/psychology MH - Young Adult MH - Universities MH - *Feeding Behavior/psychology MH - *Alcohol Drinking in College/psychology MH - Adult MH - United States MH - Reproducibility of Results MH - Adolescent MH - Feeding and Eating Disorders/psychology MH - Surveys and Questionnaires MH - Alcohol Drinking/psychology MH - Psychometrics/instrumentation MH - Motivation MH - Factor Analysis, Statistical OTO - NOTNLM OT - Alcohol OT - College students OT - Eating behaviors OT - Food and alcohol disturbance OT - Psychometrics COIS- Declaration of competing interest All authors declare that they have no conflicts of interest. EDAT- 2024/05/17 00:43 MHDA- 2024/06/02 00:43 CRDT- 2024/05/16 18:05 PHST- 2023/09/25 00:00 [received] PHST- 2024/04/10 00:00 [revised] PHST- 2024/04/10 00:00 [accepted] PHST- 2024/06/02 00:43 [medline] PHST- 2024/05/17 00:43 [pubmed] PHST- 2024/05/16 18:05 [entrez] AID - S1471-0153(24)00035-7 [pii] AID - 10.1016/j.eatbeh.2024.101876 [doi] PST - ppublish SO - Eat Behav. 2024 Apr;53:101876. doi: 10.1016/j.eatbeh.2024.101876. Epub 2024 Apr 13. PMID- 38751582 OWN - NLM STAT- MEDLINE DCOM- 20240516 LR - 20240517 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 12 DP - 2024 TI - Exploring the role of mindfulness on obligatory exercise among young athletes: mediating roles of obsessive passion and cognitive state anxiety. PG - 1381983 LID - 10.3389/fpubh.2024.1381983 [doi] LID - 1381983 AB - INTRODUCTION: In the current trend toward youthfulness and age reduction in competitive sports, the issue of obligatory exercise among young athletes is becoming more severe. This not only affects their physical and mental health but also hampers their future prospects in the sports world. While delving into the impact of mindfulness on the issue of obligatory exercise among young athletes, it reveals the mediating role of obsessive passion and cognitive state anxiety. METHODS: This study is a cross-sectional research that employs convenience and snowball sampling methods. We selected 403 young athletes from several universities and high-level sports teams in the central-southern region of China as valid samples and used AMOS v.23 to construct a structural equation model to validate the hypotheses. RESULTS: The research findings indicate a significant positive correlation between obsessive passion, cognitive state anxiety, and obligatory exercise. Furthermore, obsessive passion and cognitive state anxiety mediate the relationship between mindfulness and obligatory exercise. This implies that young athletes can better regulate their emotional state during training, manage training loads sensibly, and avoid issues with obligatory exercise through mindfulness training. DISCUSSION: In conclusion, to enhance the cognitive levels of young athletes and reduce their obligatory exercise behaviors, national sports authorities and coaching teams should develop reasonable mindfulness training programs for athletes and encourage their participation in mindfulness training. CI - Copyright (c) 2024 Li, Li, He and Wang. FAU - Li, Qianyuan AU - Li Q AD - School of Physical Education, Hunan University of Science and Technology, Xiangtan, China. FAU - Li, Li AU - Li L AD - School of Physical Education, Hunan University of Science and Technology, Xiangtan, China. FAU - He, Qianqian AU - He Q AD - Faculty of Economics, Chulalongkorn University, Bangkok, Thailand. FAU - Wang, Huilin AU - Wang H AD - School of Business, Hunan University of Science and Technology, Xiangtan, China. AD - Moray House School of Education and Sport, The University of Edinburgh, Edinburgh, United Kingdom. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240501 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Mindfulness MH - *Athletes/psychology MH - Male MH - Female MH - *Anxiety MH - *Exercise/psychology MH - Cross-Sectional Studies MH - Adolescent MH - China MH - Young Adult MH - Cognition/physiology MH - Surveys and Questionnaires MH - Obsessive Behavior/psychology PMC - PMC11094327 OTO - NOTNLM OT - cognitive state anxiety OT - mindfulness OT - obligatory exercise OT - obsessive passion OT - young athletes COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/05/16 06:42 MHDA- 2024/05/16 06:43 PMCR- 2024/05/01 CRDT- 2024/05/16 03:37 PHST- 2024/02/04 00:00 [received] PHST- 2024/04/22 00:00 [accepted] PHST- 2024/05/16 06:43 [medline] PHST- 2024/05/16 06:42 [pubmed] PHST- 2024/05/16 03:37 [entrez] PHST- 2024/05/01 00:00 [pmc-release] AID - 10.3389/fpubh.2024.1381983 [doi] PST - epublish SO - Front Public Health. 2024 May 1;12:1381983. doi: 10.3389/fpubh.2024.1381983. eCollection 2024. PMID- 38745832 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240516 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 12 DP - 2024 TI - Development and verification of machine learning model based on anogenital distance, penoscrotal distance, and 2D:4D finger ratio before puberty to predict hypospadias classification. PG - 1297642 LID - 10.3389/fped.2024.1297642 [doi] LID - 1297642 AB - OBJECTIVES: To describe the anatomical abnormalities of hypospadias before puberty using current commonly used anthropometric index data and predict postoperative diagnostic classification. METHODS: Children with hypospadias before puberty who were initially treated at Sichuan Provincial People's Hospital from April 2021 to September 2022 were selected. We recorded their preoperative penoscrotal distance, anogenital distance, 2D:4D finger ratio, and postoperative hypospadias classification. The receiver operating character curve was used for univariate analysis of the diagnostic predictive value of each index for hypospadias classification in the training set. Binary logistic regression, random forest, and support vector machine models were constructed. In addition, we also prospectively collected data from October 2022 to September 2023 as a test set to verify the constructed machine learning models. RESULTS: This study included 389 cases, with 50 distal, 167 midshaft, and 172 proximal cases. In the validation set, the sensitivity of the binary LR, RF, and SVM was 17%, 17% and 0% for identifying the distal type, 61%, 55% and 64% for identifying the midshaft type, and 56%, 60% and 48% for identifying the proximal type, respectively. The sensitivity of the three-classification RF and SVM models was 17% and 17% for distal type, 64% and 73% for midshaft type, 60% and 60% for proximal type, respectively. In the Testing set, the sensitivity of the binary LR, RF and SVM was 6%, 0% and 0% for identifying the distal type, 64%, 55% and 66% for identifying the midshaft type, and 48%, 62% and 39% for identifying the proximal type, respectively. The sensitivity of the three-classification RF and SVM models was 12% and 0% for distal type, 57% and 77% for midshaft type, and 65% and 53% for proximal type, respectively. Compared with binary classification models, the sensitivity of the three-classification models for distal type was not improved. CONCLUSION: Anogenital distance and penoscrotal distance have a favorable predictive value for midshaft and proximal hypospadias, among which AGD2, with higher test efficiency and stability, is recommended as the preferred anogenital distance indicator. The 2D:4D finger ratio (RadioL, RadioR) has little predictive value for hypospadias classification. CI - (c) 2024 He, Yang, Tang and Wang. FAU - He, Zirong AU - He Z AD - Department of Pediatric Surgery of Children's Medical Center, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Yang, Bo AU - Yang B AD - Department of Pediatric Surgery of Children's Medical Center, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Tang, Yunman AU - Tang Y AD - Department of Pediatric Surgery of Children's Medical Center, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Wang, Xuejun AU - Wang X AD - Department of Pediatric Surgery of Children's Medical Center, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. LA - eng PT - Journal Article DEP - 20240430 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC11091291 OTO - NOTNLM OT - 2D:4D finger ratio OT - anogenital distance OT - hypospadias OT - machine learning OT - penoscrotal distance COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/05/15 06:43 MHDA- 2024/05/15 06:44 PMCR- 2024/04/30 CRDT- 2024/05/15 03:49 PHST- 2023/09/20 00:00 [received] PHST- 2024/04/19 00:00 [accepted] PHST- 2024/05/15 06:44 [medline] PHST- 2024/05/15 06:43 [pubmed] PHST- 2024/05/15 03:49 [entrez] PHST- 2024/04/30 00:00 [pmc-release] AID - 10.3389/fped.2024.1297642 [doi] PST - epublish SO - Front Pediatr. 2024 Apr 30;12:1297642. doi: 10.3389/fped.2024.1297642. eCollection 2024. PMID- 38745270 OWN - NLM STAT- MEDLINE DCOM- 20240515 LR - 20240518 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 23 IP - 1 DP - 2024 May 14 TI - Development and application of the Meal and Snack Assessment (MESA) quality scale for children and adolescents using item response theory. PG - 50 LID - 10.1186/s12937-024-00948-y [doi] LID - 50 AB - BACKGROUND: Meals differ in terms of food items and nutritional quality. The aim of the present study was to propose a scale to measure the meals quality of schoolchildren according to food processing degree, perform a preliminary evaluation of the scale's validity and reliability and apply the scale to a representative sample of schoolchildren in a city in southern Brazil. METHODS: A methodological study based on the generalized graded unfolding model (GGUM) of item response theory (IRT) with analysis of secondary data was carried out in 6,399 schoolchildren of 6-15y-old attending 2nd to 5th grades of public elementary schools in Florianopolis, Brazil, in 2013-2015 who answered the validated Food Intake and Physical Activities of Schoolchildren (WebCAAFE) questionnaire. Meal quality was the latent trait. The steps for the development of the scale included: latent trait definition; item generation; dimensionality analysis; estimation of item parameters; scale levels definition; assessment of validity and reliability; and assessment of the meal quality of a subsample of schoolchildren aged 7 to 12 years (n = 6,372). RESULTS: Eleven out of eighteen items had adequate parameters, without differential item functioning for sex or age. Meal quality was categorized into three levels: healthy, mixed, and unhealthy. Higher scores indicate a greater prevalence of ultra-processed foods in daily meals. Most schoolchildren had mixed (40.6%) and unhealthy (41%) meal patterns. CONCLUSIONS: IRT analysis allowed the development of the scale, which measures the quality of meals and snacks based on the degree of food processing. At all snack times, there was a higher frequency of ultra-processed foods consumption, therefore foods consumed as snacks are a potential focus for nutritional interventions. CI - (c) 2024. The Author(s). FAU - Lemke, Stella AU - Lemke S AD - Nutrition Postgraduate Program, Department of Nutrition, Health Sciences Center, Federal University of Santa Catarina, Florianopolis, Brazil. FAU - de Andrade, Dalton Francisco AU - de Andrade DF AD - Informatics and Statistics Department, Technological Center, Federal University of Santa Catarina, Florianopolis, Brazil. FAU - de Fragas Hinnig, Patricia AU - de Fragas Hinnig P AD - Nutrition Postgraduate Program, Department of Nutrition, Health Sciences Center, Federal University of Santa Catarina, Florianopolis, Brazil. FAU - da Silva, Silvio Aparecido AU - da Silva SA AD - Knowledge Management Department, Federal Institute of Education, Science and Technology of Santa Catarina, Florianopolis, Brazil. FAU - Vincenzi, Silvana Ligia AU - Vincenzi SL AD - Informatics and Statistics Department, Technological Center, Federal University of Santa Catarina, Florianopolis, Brazil. FAU - Roberto, Denise Miguel Teixeira AU - Roberto DMT AD - Nutrition Postgraduate Program, Department of Nutrition, Health Sciences Center, Federal University of Santa Catarina, Florianopolis, Brazil. FAU - Lobo, Adriana Soares AU - Lobo AS AD - Nutrition Postgraduate Program, Department of Nutrition, Health Sciences Center, Federal University of Santa Catarina, Florianopolis, Brazil. FAU - Vieira, Francilene Gracieli Kunradi AU - Vieira FGK AD - Nutrition Postgraduate Program, Department of Nutrition, Health Sciences Center, Federal University of Santa Catarina, Florianopolis, Brazil. FAU - Di Pietro, Patricia Faria AU - Di Pietro PF AUID- ORCID: 0000-0003-1343-5049 AD - Nutrition Postgraduate Program, Department of Nutrition, Health Sciences Center, Federal University of Santa Catarina, Florianopolis, Brazil. patricia.di.pietro@ufsc.br. AD - Federal University of Santa Catarina, Campus Trindade, Florianopolis, Santa Catarina, 88040-370, Brazil. patricia.di.pietro@ufsc.br. FAU - de Assis, Maria Alice Altenburg AU - de Assis MAA AD - Nutrition Postgraduate Program, Department of Nutrition, Health Sciences Center, Federal University of Santa Catarina, Florianopolis, Brazil. LA - eng GR - 305148/2011-7/Brazilian National Council for Scientific and Technological Development - CNPq/ PT - Journal Article DEP - 20240514 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 SB - IM MH - Humans MH - Child MH - Female MH - *Snacks MH - Male MH - Adolescent MH - Brazil MH - Reproducibility of Results MH - *Meals MH - Surveys and Questionnaires/standards MH - Nutritive Value MH - Nutrition Assessment MH - Food Handling/methods MH - Schools PMC - PMC11092231 OTO - NOTNLM OT - Diet quality OT - Mealtimes OT - Scales OT - Ultra-processed foods COIS- The authors declare that they have no competing interests. EDAT- 2024/05/15 05:45 MHDA- 2024/05/15 06:42 PMCR- 2024/05/14 CRDT- 2024/05/14 23:55 PHST- 2024/02/21 00:00 [received] PHST- 2024/04/10 00:00 [accepted] PHST- 2024/05/15 06:42 [medline] PHST- 2024/05/15 05:45 [pubmed] PHST- 2024/05/14 23:55 [entrez] PHST- 2024/05/14 00:00 [pmc-release] AID - 10.1186/s12937-024-00948-y [pii] AID - 948 [pii] AID - 10.1186/s12937-024-00948-y [doi] PST - epublish SO - Nutr J. 2024 May 14;23(1):50. doi: 10.1186/s12937-024-00948-y. PMID- 38745053 OWN - NLM STAT- MEDLINE DCOM- 20241105 LR - 20250403 IS - 1476-5640 (Electronic) IS - 0954-3007 (Print) IS - 0954-3007 (Linking) VI - 78 IP - 11 DP - 2024 Nov TI - Statistical assessment of reliability of anthropometric measurements in the multi-site South African National Dietary Intake Survey 2022. PG - 1005-1013 LID - 10.1038/s41430-024-01449-1 [doi] AB - BACKGROUND: Anthropometric data quality in large multicentre nutrition surveys is seldom adequately assessed. In preparation for the South African National Dietary Intake Survey (NDIS-2022), this study assessed site leads' and fieldworkers' intra- and inter-rater reliability for measuring weight, length/height, mid-upper arm circumference (MUAC), waist circumference (WC) and calf circumference (CC). METHODS: Standardised training materials and measurement protocols were developed, and new anthropometric equipment was procured. Following two training rounds (12 site lead teams, 46 fieldworker teams), measurement reliability was assessed for both groups, using repeated measurements of volunteers similar to the survey target population. Reliability was statistically assessed using the technical error of measurement (TEM), relative TEM (%TEM), intra-class correlation coefficient (ICC) and coefficient of reliability (R). Agreement was visualised with Bland-Altman analysis. RESULTS: By %TEM, the best reliability was achieved for weight (%TEM = 0.260-0.923) and length/height (%TEM = 0.434-0.855), and the poorest for MUAC by fieldworkers (%TEM = 2.592-3.199) and WC (%TEM = 2.353-2.945). Whole-sample ICC and R were excellent ( > 0.90) for all parameters except site leads' CC inter-rater reliability (ICC = 0.896, R = 0.889) and fieldworkers' inter-rater reliability for MUAC in children under two (ICC = 0.851, R = 0.881). Bland-Altman analysis revealed no significant bias except in fieldworkers' intra-rater reliability of length/height measurement in adolescents/adults ( + 0.220 (0.042, 0.400) cm). Reliability was higher for site leads vs. fieldworkers, for intra-rater vs. inter-rater assessment, and for weight and length/height vs. circumference measurements. CONCLUSION: NDIS-2022 site leads and fieldworkers displayed acceptable reliability in performing anthropometric measurements, highlighting the importance of intensive training and standardised measurement protocols. Ongoing reliability assessment during data collection is recommended. CI - (c) 2024. The Author(s). FAU - Nel, Sanja AU - Nel S AUID- ORCID: 0000-0003-3175-7340 AD - University of Pretoria, Department of Human Nutrition, Faculty of Health Sciences, Pretoria, South Africa. nel.sanja@gmail.com. AD - University of Pretoria Research Centre for Maternal, Fetal, Newborn & Child Health Care Strategies, Kalafong Hospital, Atteridgeville, South Africa. nel.sanja@gmail.com. AD - South African Medical Research Council (SA MRC) Maternal and Infant Health Care Strategies Unit, Kalafong Hospital, Atteridgeville, South Africa. nel.sanja@gmail.com. FAU - de Man, Jeroen AU - de Man J AUID- ORCID: 0000-0002-3196-8757 AD - School of Public Health, Faculty of Community and Health Sciences, University of the Western Cape, Cape Town, South Africa. AD - Department of Family Medicine and Population Health, University of Antwerp, Antwerp, Belgium. FAU - van den Berg, Louise AU - van den Berg L AD - University of the Free State, Department of Nutrition and Dietetics, School of Health and Rehabilitation Sciences, Faculty of Health Sciences, Bloemfontein, South Africa. FAU - Wenhold, Friedeburg Anna Maria AU - Wenhold FAM AUID- ORCID: 0000-0003-1140-5065 AD - University of Pretoria, Department of Human Nutrition, Faculty of Health Sciences, Pretoria, South Africa. AD - University of Pretoria Research Centre for Maternal, Fetal, Newborn & Child Health Care Strategies, Kalafong Hospital, Atteridgeville, South Africa. AD - South African Medical Research Council (SA MRC) Maternal and Infant Health Care Strategies Unit, Kalafong Hospital, Atteridgeville, South Africa. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20240514 PL - England TA - Eur J Clin Nutr JT - European journal of clinical nutrition JID - 8804070 SB - IM MH - Humans MH - South Africa MH - Reproducibility of Results MH - *Anthropometry/methods MH - Male MH - Female MH - *Nutrition Surveys/methods MH - Adult MH - Adolescent MH - Body Weight MH - Diet Surveys/standards/methods MH - Young Adult MH - Body Height MH - Middle Aged MH - Waist Circumference MH - Child PMC - PMC11537951 COIS- The authors declare no competing interests. EDAT- 2024/05/15 05:45 MHDA- 2024/11/06 00:22 PMCR- 2024/05/14 CRDT- 2024/05/14 23:40 PHST- 2023/12/13 00:00 [received] PHST- 2024/04/30 00:00 [accepted] PHST- 2024/04/26 00:00 [revised] PHST- 2024/11/06 00:22 [medline] PHST- 2024/05/15 05:45 [pubmed] PHST- 2024/05/14 23:40 [entrez] PHST- 2024/05/14 00:00 [pmc-release] AID - 10.1038/s41430-024-01449-1 [pii] AID - 1449 [pii] AID - 10.1038/s41430-024-01449-1 [doi] PST - ppublish SO - Eur J Clin Nutr. 2024 Nov;78(11):1005-1013. doi: 10.1038/s41430-024-01449-1. Epub 2024 May 14. PMID- 38744402 OWN - NLM STAT- MEDLINE DCOM- 20240530 LR - 20240923 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 199 DP - 2024 Aug 1 TI - Development and evaluation of a food literacy questionnaire for schoolchildren in France. PG - 107420 LID - S0195-6663(24)00223-X [pii] LID - 10.1016/j.appet.2024.107420 [doi] AB - Food literacy is gaining importance in nutrition education programs for children. To date, food literacy assessment tools have been developed in many countries, however, none exist in France. The objectives of this study were to develop a questionnaire and to evaluate its measurement properties among French schoolchildren aged 8-11 years. The questionnaire was developed in three phases: i) item selection (literature review and adaptation or creation of items) and content validity (submission to an expert panel), ii) questionnaire development including a pre-test in a small sample of children (n = 41) and item reduction and dimensionality based on the responses of children who completed the questionnaire in 31 schools between December 2022 and March 2023, and iii) questionnaire evaluation in terms of reliability, validity and acceptability. In total, 1187 responses were included in the analysis. The mean age of the children was 9.6 +/- 0.7 years (girls: 51.2%, boys: 48.8%). The development process resulted in a 25-item questionnaire with good acceptability and satisfactory estimated reliability (McDonald omega coefficient = 0.73). Factor evaluation revealed a three-dimensional structure encompassing food and nutrition knowledge, participation in food preparation activities and food habits. To our knowledge, this study was the first to assess food literacy for schoolchildren in France. Our questionnaire can contribute to assess the factors that make food literacy vary, especially regarding socioeconomic variables to target priority populations for nutrition education actions and to describe changes in food literacy scores from a longitudinal perspective. CI - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Dallant, Titiane AU - Dallant T AD - Epidemiology and Public Health Department, Raymond Poincare Hospital, AP-HP, Garches, France. FAU - Bozonnet, Amandine AU - Bozonnet A AD - Fondation JDB Prevention Cancer, Fontenay-les-Briis, France. FAU - Delarocque-Astagneau, Elisabeth AU - Delarocque-Astagneau E AD - Epidemiology and Public Health Department, Raymond Poincare Hospital, AP-HP, Garches, France; UFR Simone-Veil Sante, Universite Versailles St-Quentin-en-Yvelines (UVSQ), Montigny-le-Bretonneux, France; Center for Research in Epidemiology and Population Health (CESP), Inserm U1018, UVSQ, Paris-Saclay University, Villejuif, France. FAU - Gautier, Sylvain AU - Gautier S AD - Epidemiology and Public Health Department, Raymond Poincare Hospital, AP-HP, Garches, France; UFR Simone-Veil Sante, Universite Versailles St-Quentin-en-Yvelines (UVSQ), Montigny-le-Bretonneux, France; Center for Research in Epidemiology and Population Health (CESP), Inserm U1018, UVSQ, Paris-Saclay University, Villejuif, France. FAU - Kone, Ali AU - Kone A AD - Fondation JDB Prevention Cancer, Fontenay-les-Briis, France. FAU - Grasteau, Vincent AU - Grasteau V AD - Fondation JDB Prevention Cancer, Fontenay-les-Briis, France. FAU - Rouquette, Alexandra AU - Rouquette A AD - Center for Research in Epidemiology and Population Health (CESP), Inserm U1018, UVSQ, Paris-Saclay University, Villejuif, France; Public Health Department, Bicetre Hospital, AP-HP, Bicetre, France; UFR de medecine, Universite Paris-Saclay, Bicetre, France. FAU - Herr, Marie AU - Herr M AD - Epidemiology and Public Health Department, Raymond Poincare Hospital, AP-HP, Garches, France; UFR Simone-Veil Sante, Universite Versailles St-Quentin-en-Yvelines (UVSQ), Montigny-le-Bretonneux, France; Center for Research in Epidemiology and Population Health (CESP), Inserm U1018, UVSQ, Paris-Saclay University, Villejuif, France. Electronic address: marie.herr@uvsq.fr. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20240512 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Child MH - France MH - Male MH - Female MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - *Health Literacy MH - *Feeding Behavior/psychology MH - Health Knowledge, Attitudes, Practice MH - Schools OTO - NOTNLM OT - Children OT - Food literacy OT - Health education OT - Health program OT - Nutrition COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/05/15 05:45 MHDA- 2024/05/31 00:42 CRDT- 2024/05/14 19:14 PHST- 2024/01/15 00:00 [received] PHST- 2024/04/25 00:00 [revised] PHST- 2024/05/11 00:00 [accepted] PHST- 2024/05/31 00:42 [medline] PHST- 2024/05/15 05:45 [pubmed] PHST- 2024/05/14 19:14 [entrez] AID - S0195-6663(24)00223-X [pii] AID - 10.1016/j.appet.2024.107420 [doi] PST - ppublish SO - Appetite. 2024 Aug 1;199:107420. doi: 10.1016/j.appet.2024.107420. Epub 2024 May 12. PMID- 38744196 OWN - NLM STAT- MEDLINE DCOM- 20240529 LR - 20240529 IS - 1873-6807 (Electronic) IS - 1740-1445 (Linking) VI - 49 DP - 2024 Jun TI - Sample characteristics for quantitative analyses in Body Image: Issues of generalisability. PG - 101714 LID - S1740-1445(24)00036-6 [pii] LID - 10.1016/j.bodyim.2024.101714 [doi] AB - Psychological research frequently encounters criticism regarding the representativeness of the samples under study, highlighting concerns about the external validity of the obtained results. Here, we conducted a comprehensive survey of all the quantitative samples from the journal Body Image for 2021 (n = 149 samples). Our primary objective was to examine the extent to which the sampled populations deviated from the population at large, which could potentially compromise the generalizability of findings. We identified that a substantial number of these samples came from student populations (n = 44) and the majority were from the United States, United Kingdom, and Australia. Only a small number of samples (n = 9) employed direct measurements of body mass index (BMI), while the majority relied on self-reported data (n = 93). For a subset of samples in the journal, which were drawn from the general population, we compared whether these differed from population reference values in terms of age and BMI. Using Monte Carlo simulations, we found that samples tended to be younger and score lower on BMI than reference values obtained from the broader population. Samples drawn from female university students also tended to be lower on BMI than age-matched reference samples. We discuss the implications of our findings and make recommendations on sampling and inference. We conclude that a clearer specification of the parameters or conditions under which findings are expected to generalise has the potential to enhance the overall rigor and validity of this field of research. CI - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Pollet, Thomas V AU - Pollet TV AD - Dept. of Psychology, Northumbria University, UK. Electronic address: thomas.pollet@northumbria.ac.uk. FAU - Bovet, Jeanne AU - Bovet J AD - Dept. of Psychology, Northumbria University, UK. FAU - Buhaenko, Rosie AU - Buhaenko R AD - Dept. of Psychology, Northumbria University, UK. FAU - Cornelissen, Piers L AU - Cornelissen PL AD - Dept. of Psychology, Northumbria University, UK. FAU - Tovee, Martin J AU - Tovee MJ AD - Dept. of Psychology, Northumbria University, UK. LA - eng PT - Journal Article DEP - 20240513 PL - Netherlands TA - Body Image JT - Body image JID - 101222431 SB - IM MH - Humans MH - *Body Image/psychology MH - Female MH - *Body Mass Index MH - Adult MH - Male MH - Young Adult MH - Adolescent MH - Australia MH - United Kingdom MH - United States OTO - NOTNLM OT - External validity OT - Methodology OT - Monte Carlo Simulation OT - Sampling COIS- Declaration of Competing Interest No conflict of interests are known to the authors. EDAT- 2024/05/15 05:43 MHDA- 2024/05/30 05:43 CRDT- 2024/05/14 18:09 PHST- 2023/06/09 00:00 [received] PHST- 2024/04/02 00:00 [revised] PHST- 2024/04/09 00:00 [accepted] PHST- 2024/05/30 05:43 [medline] PHST- 2024/05/15 05:43 [pubmed] PHST- 2024/05/14 18:09 [entrez] AID - S1740-1445(24)00036-6 [pii] AID - 10.1016/j.bodyim.2024.101714 [doi] PST - ppublish SO - Body Image. 2024 Jun;49:101714. doi: 10.1016/j.bodyim.2024.101714. Epub 2024 May 13. PMID- 38743472 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240531 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 8 DP - 2024 May 14 TI - Exploring Children's Knowledge of Healthy Eating, Digital Media Use, and Caregivers' Perspectives to Inform Design and Contextual Considerations for Game-Based Interventions in Schools for Low-Income Families in Lima, Peru: Survey Study. PG - e49168 LID - 10.2196/49168 [doi] LID - e49168 AB - BACKGROUND: The prevalence of overweight and obesity in schoolchildren is increasing in Peru. Given the increased use of digital media, there is potential to develop effective digital health interventions to promote healthy eating practices at schools. This study investigates the needs of schoolchildren in relation to healthy eating and the potential role of digital media to inform the design of game-based nutritional interventions. OBJECTIVE: This study aims to explore schoolchildren's knowledge about healthy eating and use of and preferences for digital media to inform the future development of a serious game to promote healthy eating. METHODS: A survey was conducted in 17 schools in metropolitan Lima, Peru. The information was collected virtually with specific questions for the schoolchild and their caregiver during October 2021 and November 2021 and following the COVID-19 public health restrictions. Questions on nutritional knowledge and preferences for and use of digital media were included. In the descriptive analysis, the percentages of the variables of interest were calculated. RESULTS: We received 3937 validated responses from caregivers and schoolchildren. The schoolchildren were aged between 8 years and 15 years (2030/3937, 55.8% girls). Of the caregivers, 83% (3267/3937) were mothers, and 56.5% (2223/3937) had a secondary education. Only 5.2% (203/3937) of schoolchildren's homes did not have internet access; such access was through WiFi (2151/3937, 54.6%) and mobile internet (1314/3937, 33.4%). In addition, 95.3% (3753/3937) of schoolchildren's homes had a mobile phone; 31.3% (1233/3937) had computers. In relation to children's knowledge on healthy eating, 42.2% (1663/3937) of schoolchildren did not know the recommendation to consume at least 5 servings of fruits and vegetables daily, 46.7% (1837/3937) of schoolchildren did not identify front-of-package warning labels (FOPWLs), and 63.9% (2514/3937) did not relate the presence of an FOPWL with dietary risk. Most schoolchildren (3100/3937, 78.7%) preferred to use a mobile phone. Only 38.3% (1509/3937) indicated they preferred a computer. In addition, 47.9% (1885/3937) of caregivers considered that the internet helps in the education of schoolchildren, 82.7% (3254/3937) of caregivers gave permission for schoolchildren to play games with digital devices, and 38% (1495/3937) of caregivers considered that traditional digital games for children are inadequate. CONCLUSIONS: The results suggest that knowledge about nutrition in Peruvian schoolchildren has limitations. Most schoolchildren have access to the internet, with mobile phones being the device type with the greatest availability and preference for use. Caregivers' perspectives on games and schoolchildren, including a greater interest in using digital games, provide opportunities for the design and development of serious games to improve schoolchildren's nutritional knowledge in Peru. Future research is needed to explore the potential of serious games that are tailored to the needs and preferences of both schoolchildren and their caregivers in Peru in order to promote healthy eating. CI - (c)Bladimir Morales-Cahuancama, Nervo Verdezoto, Elena Gonzales-Achuy, Cinthia Quispe-Gala, William Bautista-Olortegui, Paul Hinojosa-Mamani, Juan Pablo Aparco. Originally published in JMIR Formative Research (https://formative.jmir.org), 14.05.2024. FAU - Morales-Cahuancama, Bladimir AU - Morales-Cahuancama B AUID- ORCID: 0000-0002-8304-7781 AD - Centro Nacional de Alimentacion, Nutricion y Vida Saludable, Instituto Nacional de Salud, Lima, Peru. AD - Programa Academico de Nutricion y Dietetica, Facultad de ciencias de la salud, Universidad Peruana de Ciencias Aplicadas, Lima, Peru. FAU - Verdezoto, Nervo AU - Verdezoto N AUID- ORCID: 0000-0001-5006-4262 AD - School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom. FAU - Gonzales-Achuy, Elena AU - Gonzales-Achuy E AUID- ORCID: 0000-0002-2160-5629 AD - Centro Nacional de Alimentacion, Nutricion y Vida Saludable, Instituto Nacional de Salud, Lima, Peru. FAU - Quispe-Gala, Cinthia AU - Quispe-Gala C AUID- ORCID: 0000-0002-8306-8283 AD - Centro Nacional de Alimentacion, Nutricion y Vida Saludable, Instituto Nacional de Salud, Lima, Peru. FAU - Bautista-Olortegui, William AU - Bautista-Olortegui W AUID- ORCID: 0000-0002-1815-8952 AD - Centro Nacional de Alimentacion, Nutricion y Vida Saludable, Instituto Nacional de Salud, Lima, Peru. FAU - Hinojosa-Mamani, Paul AU - Hinojosa-Mamani P AUID- ORCID: 0000-0002-1592-4586 AD - Centro Nacional de Alimentacion, Nutricion y Vida Saludable, Instituto Nacional de Salud, Lima, Peru. FAU - Aparco, Juan Pablo AU - Aparco JP AUID- ORCID: 0000-0001-9159-7997 AD - Centro Nacional de Alimentacion, Nutricion y Vida Saludable, Instituto Nacional de Salud, Lima, Peru. AD - Escuela Profesional de Nutricion, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Peru. LA - eng PT - Journal Article DEP - 20240514 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 PMC - PMC11134240 OTO - NOTNLM OT - adolescent OT - caregivers' perspectives OT - child OT - children OT - diet OT - digital games OT - digital media OT - formative research OT - healthy eating OT - mHealth OT - nutrition OT - obese OT - obesity OT - overweight OT - perspective OT - perspectives OT - schoolchildren OT - serious game OT - serious games OT - student OT - students OT - youth COIS- Conflicts of Interest: None declared. EDAT- 2024/05/15 05:47 MHDA- 2024/05/15 05:48 PMCR- 2024/05/14 CRDT- 2024/05/14 11:54 PHST- 2023/05/19 00:00 [received] PHST- 2024/02/19 00:00 [accepted] PHST- 2024/02/15 00:00 [revised] PHST- 2024/05/15 05:48 [medline] PHST- 2024/05/15 05:47 [pubmed] PHST- 2024/05/14 11:54 [entrez] PHST- 2024/05/14 00:00 [pmc-release] AID - v8i1e49168 [pii] AID - 10.2196/49168 [doi] PST - epublish SO - JMIR Form Res. 2024 May 14;8:e49168. doi: 10.2196/49168. PMID- 38738918 OWN - NLM STAT- MEDLINE DCOM- 20240827 LR - 20261012 IS - 1097-6817 (Electronic) IS - 0194-5998 (Linking) VI - 171 IP - 3 DP - 2024 Sep TI - A Comparison of Drug-Induced Sleep Endoscopy Findings in Infants and Toddlers. PG - 888-893 LID - 10.1002/ohn.810 [doi] AB - OBJECTIVE: To compare patterns of obstruction in infants and toddlers with obstructive sleep apnea (OSA) by analyzing drug-induced sleep endoscopy (DISE) examinations. STUDY DESIGN: Retrospective chart review. SETTING: An academic tertiary care pediatric hospital at a single institution. METHODS: Children aged 1